id	sid	tid	token	lemma	pos
admet-2603	1	1	natural	natural	ADJ
admet-2603	1	2	polymer	polymer	NOUN
admet-2603	1	3	derivative	derivative	NOUN
admet-2603	1	4	-	-	PUNCT
admet-2603	1	5	based	base	VERB
admet-2603	1	6	ph	ph	ADJ
admet-2603	1	7	responsive	responsive	ADJ
admet-2603	1	8	nanoformulations	nanoformulation	NOUN
admet-2603	1	9	with	with	ADP
admet-2603	1	10	entrapped	entrapped	ADJ
admet-2603	1	11	diketo	diketo	NOUN
admet-2603	1	12	-	-	PUNCT
admet-2603	1	13	tautomers	tautomer	NOUN
admet-2603	1	14	of	of	ADP
admet-2603	1	15	5	5	NUM
admet-2603	1	16	-	-	PUNCT
admet-2603	1	17	fluorouracil	fluorouracil	NOUN
admet-2603	1	18	for	for	ADP
admet-2603	1	19	enhanced	enhanced	ADJ
admet-2603	1	20	cancer	cancer	NOUN
admet-2603	1	21	therapy	therapy	NOUN
admet-2603	1	22	doi	doi	PROPN
admet-2603	1	23	:	:	PUNCT
admet-2603	1	24	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	PROPN
admet-2603	1	25	1	1	NUM
admet-2603	1	26	admet	admet	X
admet-2603	1	27	&	&	CCONJ
admet-2603	1	28	dmpk	dmpk	PROPN
admet-2603	1	29	13(1	13(1	NUM
admet-2603	1	30	)	)	PUNCT
admet-2603	1	31	(	(	PUNCT
admet-2603	1	32	2025	2025	NUM
admet-2603	1	33	)	)	PUNCT
admet-2603	1	34	2603	2603	NUM
admet-2603	1	35	;	;	PUNCT
admet-2603	1	36	doi	doi	NOUN
admet-2603	1	37	:	:	PUNCT
admet-2603	1	38	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	1	39	open	open	VERB
admet-2603	1	40	access	access	NOUN
admet-2603	1	41	:	:	PUNCT
admet-2603	1	42	issn	issn	PROPN
admet-2603	1	43	:	:	PUNCT
admet-2603	1	44	1848	1848	NUM
admet-2603	1	45	-	-	SYM
admet-2603	1	46	7718	7718	NUM
admet-2603	1	47	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2603	1	48	original	original	ADJ
admet-2603	1	49	scientific	scientific	ADJ
admet-2603	1	50	paper	paper	NOUN
admet-2603	1	51	effect	effect	NOUN
admet-2603	1	52	of	of	ADP
admet-2603	1	53	bicarbonate	bicarbonate	NOUN
admet-2603	1	54	buffer	buffer	NOUN
admet-2603	1	55	on	on	ADP
admet-2603	1	56	artificial	artificial	ADJ
admet-2603	1	57	membrane	membrane	NOUN
admet-2603	1	58	permeation	permeation	NOUN
admet-2603	1	59	of	of	ADP
admet-2603	1	60	drugs	drug	NOUN
admet-2603	1	61	shiori	shiori	PROPN
admet-2603	1	62	ishida1	ishida1	PROPN
admet-2603	1	63	,	,	PUNCT
admet-2603	1	64	samuel	samuel	PROPN
admet-2603	1	65	lee2	lee2	PROPN
admet-2603	1	66	,	,	PUNCT
admet-2603	1	67	balint	balint	PROPN
admet-2603	1	68	sinko2	sinko2	PROPN
admet-2603	1	69	,	,	PUNCT
admet-2603	1	70	karl	karl	PROPN
admet-2603	1	71	box2	box2	PROPN
admet-2603	1	72	and	and	CCONJ
admet-2603	1	73	kiyohiko	kiyohiko	VERB
admet-2603	1	74	sugano1	sugano1	PROPN
admet-2603	1	75	*	*	PROPN
admet-2603	1	76	1molecular	1molecular	NUM
admet-2603	1	77	pharmaceutics	pharmaceutic	NOUN
admet-2603	1	78	lab	lab	NOUN
admet-2603	1	79	.	.	PUNCT
admet-2603	1	80	,	,	PUNCT
admet-2603	1	81	college	college	NOUN
admet-2603	1	82	of	of	ADP
admet-2603	1	83	pharmaceutical	pharmaceutical	NOUN
admet-2603	1	84	sciences	science	NOUN
admet-2603	1	85	,	,	PUNCT
admet-2603	1	86	ritsumeikan	ritsumeikan	ADJ
admet-2603	1	87	university	university	NOUN
admet-2603	1	88	,	,	PUNCT
admet-2603	1	89	1	1	NUM
admet-2603	1	90	-	-	SYM
admet-2603	1	91	1	1	NUM
admet-2603	1	92	-	-	SYM
admet-2603	1	93	1	1	NUM
admet-2603	1	94	,	,	PUNCT
admet-2603	1	95	noji	noji	NOUN
admet-2603	1	96	-	-	PUNCT
admet-2603	1	97	higashi	higashi	PROPN
admet-2603	1	98	,	,	PUNCT
admet-2603	1	99	kusatsu	kusatsu	NOUN
admet-2603	1	100	,	,	PUNCT
admet-2603	1	101	shiga	shiga	NOUN
admet-2603	1	102	525	525	NUM
admet-2603	1	103	-	-	SYM
admet-2603	1	104	8577	8577	NUM
admet-2603	1	105	,	,	PUNCT
admet-2603	1	106	japan	japan	PROPN
admet-2603	1	107	2pion	2pion	NUM
admet-2603	1	108	inc	inc	PROPN
admet-2603	1	109	.	.	PUNCT
admet-2603	1	110	(	(	PUNCT
admet-2603	1	111	uk	uk	PROPN
admet-2603	1	112	)	)	PUNCT
admet-2603	1	113	ltd	ltd	PROPN
admet-2603	1	114	.	.	PROPN
admet-2603	1	115	forest	forest	PROPN
admet-2603	1	116	row	row	PROPN
admet-2603	1	117	business	business	NOUN
admet-2603	1	118	park	park	NOUN
admet-2603	1	119	,	,	PUNCT
admet-2603	1	120	station	station	NOUN
admet-2603	1	121	road	road	NOUN
admet-2603	1	122	,	,	PUNCT
admet-2603	1	123	east	east	PROPN
admet-2603	1	124	sussex	sussex	NOUN
admet-2603	1	125	,	,	PUNCT
admet-2603	1	126	rh18	rh18	PROPN
admet-2603	1	127	5dw	5dw	NOUN
admet-2603	1	128	,	,	PUNCT
admet-2603	1	129	united	united	ADJ
admet-2603	1	130	kingdom	kingdom	PROPN
admet-2603	1	131	*	*	PUNCT
admet-2603	1	132	corresponding	correspond	VERB
admet-2603	1	133	author	author	NOUN
admet-2603	1	134	:	:	PUNCT
admet-2603	1	135	e	e	NOUN
admet-2603	1	136	-	-	NOUN
admet-2603	1	137	mail	mail	NOUN
admet-2603	1	138	:	:	PUNCT
admet-2603	1	139	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-2603	1	140	;	;	PUNCT
admet-2603	1	141	tel	tel	PROPN
admet-2603	1	142	.	.	PROPN
admet-2603	1	143	:	:	PUNCT
admet-2603	2	1	+81	+81	PROPN
admet-2603	2	2	-	-	PUNCT
admet-2603	2	3	77	77	NUM
admet-2603	2	4	-	-	PUNCT
admet-2603	2	5	561	561	NUM
admet-2603	2	6	-	-	PUNCT
admet-2603	2	7	2773	2773	NUM
admet-2603	2	8	received	receive	VERB
admet-2603	2	9	:	:	PUNCT
admet-2603	2	10	december	december	PROPN
admet-2603	2	11	1	1	NUM
admet-2603	2	12	,	,	PUNCT
admet-2603	2	13	2024	2024	NUM
admet-2603	2	14	;	;	PUNCT
admet-2603	2	15	revised	revise	VERB
admet-2603	2	16	:	:	PUNCT
admet-2603	2	17	january	january	PROPN
admet-2603	2	18	14	14	NUM
admet-2603	2	19	,	,	PUNCT
admet-2603	2	20	2025	2025	NUM
admet-2603	2	21	;	;	PUNCT
admet-2603	2	22	published	publish	VERB
admet-2603	2	23	:	:	PUNCT
admet-2603	2	24	january	january	PROPN
admet-2603	2	25	18	18	NUM
admet-2603	2	26	,	,	PUNCT
admet-2603	2	27	2025	2025	NUM
admet-2603	2	28	abstract	abstract	ADJ
admet-2603	2	29	background	background	NOUN
admet-2603	2	30	and	and	CCONJ
admet-2603	2	31	purpose	purpose	NOUN
admet-2603	2	32	:	:	PUNCT
admet-2603	2	33	the	the	DET
admet-2603	2	34	ph	ph	ADJ
admet-2603	2	35	value	value	NOUN
admet-2603	2	36	of	of	ADP
admet-2603	2	37	the	the	DET
admet-2603	2	38	small	small	ADJ
admet-2603	2	39	intestine	intestine	NOUN
admet-2603	2	40	is	be	AUX
admet-2603	2	41	physiologically	physiologically	ADV
admet-2603	2	42	maintained	maintain	VERB
admet-2603	2	43	by	by	ADP
admet-2603	2	44	bicarbonate	bicarbonate	NOUN
admet-2603	2	45	buffer	buffer	NOUN
admet-2603	2	46	(	(	PUNCT
admet-2603	2	47	bcb	bcb	PROPN
admet-2603	2	48	)	)	PUNCT
admet-2603	2	49	.	.	PUNCT
admet-2603	3	1	however	however	ADV
admet-2603	3	2	,	,	PUNCT
admet-2603	3	3	the	the	DET
admet-2603	3	4	effect	effect	NOUN
admet-2603	3	5	of	of	ADP
admet-2603	3	6	bcb	bcb	PROPN
admet-2603	3	7	on	on	ADP
admet-2603	3	8	the	the	DET
admet-2603	3	9	membrane	membrane	NOUN
admet-2603	3	10	permeation	permeation	NOUN
admet-2603	3	11	of	of	ADP
admet-2603	3	12	drugs	drug	NOUN
admet-2603	3	13	has	have	AUX
admet-2603	3	14	not	not	PART
admet-2603	3	15	been	be	AUX
admet-2603	3	16	investigated	investigate	VERB
admet-2603	3	17	.	.	PUNCT
admet-2603	4	1	the	the	DET
admet-2603	4	2	purpose	purpose	NOUN
admet-2603	4	3	of	of	ADP
admet-2603	4	4	this	this	DET
admet-2603	4	5	study	study	NOUN
admet-2603	4	6	was	be	AUX
admet-2603	4	7	to	to	PART
admet-2603	4	8	investigate	investigate	VERB
admet-2603	4	9	the	the	DET
admet-2603	4	10	effect	effect	NOUN
admet-2603	4	11	of	of	ADP
admet-2603	4	12	bcb	bcb	PROPN
admet-2603	4	13	on	on	ADP
admet-2603	4	14	the	the	DET
admet-2603	4	15	passive	passive	ADJ
admet-2603	4	16	membrane	membrane	NOUN
admet-2603	4	17	permeation	permeation	NOUN
admet-2603	4	18	of	of	ADP
admet-2603	4	19	drugs	drug	NOUN
admet-2603	4	20	.	.	PUNCT
admet-2603	5	1	experimental	experimental	ADJ
admet-2603	5	2	approach	approach	NOUN
admet-2603	5	3	:	:	PUNCT
admet-2603	5	4	the	the	DET
admet-2603	5	5	μflux	μflux	NOUN
admet-2603	5	6	apparatus	apparatus	NOUN
admet-2603	5	7	(	(	PUNCT
admet-2603	5	8	pion	pion	PROPN
admet-2603	5	9	inc	inc	PROPN
admet-2603	5	10	.	.	PROPN
admet-2603	5	11	)	)	PUNCT
admet-2603	5	12	was	be	AUX
admet-2603	5	13	used	use	VERB
admet-2603	5	14	for	for	ADP
admet-2603	5	15	permeability	permeability	NOUN
admet-2603	5	16	measurements	measurement	NOUN
admet-2603	5	17	.	.	PUNCT
admet-2603	6	1	to	to	PART
admet-2603	6	2	avoid	avoid	VERB
admet-2603	6	3	a	a	DET
admet-2603	6	4	ph	ph	ADJ
admet-2603	6	5	change	change	NOUN
admet-2603	6	6	of	of	ADP
admet-2603	6	7	bcb	bcb	PROPN
admet-2603	6	8	,	,	PUNCT
admet-2603	6	9	a	a	DET
admet-2603	6	10	floating	float	VERB
admet-2603	6	11	lid	lid	NOUN
admet-2603	6	12	was	be	AUX
admet-2603	6	13	newly	newly	ADV
admet-2603	6	14	developed	develop	VERB
admet-2603	6	15	for	for	ADP
admet-2603	6	16	μflux	μflux	NOUN
admet-2603	6	17	.	.	PUNCT
admet-2603	7	1	the	the	DET
admet-2603	7	2	membrane	membrane	NOUN
admet-2603	7	3	filter	filter	NOUN
admet-2603	7	4	was	be	AUX
admet-2603	7	5	coated	coat	VERB
admet-2603	7	6	with	with	ADP
admet-2603	7	7	a	a	DET
admet-2603	7	8	10	10	NUM
admet-2603	7	9	%	%	NOUN
admet-2603	7	10	soybean	soybean	NOUN
admet-2603	7	11	lecithin	lecithin	NOUN
admet-2603	7	12	-	-	PUNCT
admet-2603	7	13	decane	decane	NOUN
admet-2603	7	14	solution	solution	NOUN
admet-2603	7	15	.	.	PUNCT
admet-2603	8	1	the	the	DET
admet-2603	8	2	flux	flux	PROPN
admet-2603	8	3	measurement	measurement	NOUN
admet-2603	8	4	was	be	AUX
admet-2603	8	5	performed	perform	VERB
admet-2603	8	6	in	in	ADP
admet-2603	8	7	an	an	DET
admet-2603	8	8	iso	iso	NOUN
admet-2603	8	9	-	-	PUNCT
admet-2603	8	10	ph	ph	ADJ
admet-2603	8	11	condition	condition	NOUN
admet-2603	8	12	(	(	PUNCT
admet-2603	8	13	ph	ph	PROPN
admet-2603	8	14	6.5	6.5	NUM
admet-2603	8	15	,	,	PUNCT
admet-2603	8	16	bcb	bcb	PROPN
admet-2603	8	17	=	=	PROPN
admet-2603	8	18	10	10	NUM
admet-2603	8	19	mm	mm	NOUN
admet-2603	8	20	,	,	PUNCT
admet-2603	8	21	buffer	buffer	NOUN
admet-2603	8	22	capacity	capacity	NOUN
admet-2603	8	23	(	(	PUNCT
admet-2603	8	24	)=	)=	PROPN
admet-2603	8	25	4.4	4.4	NUM
admet-2603	8	26	mm	mm	NUM
admet-2603	8	27	ph-1	ph-1	PROPN
admet-2603	8	28	)	)	PUNCT
admet-2603	8	29	.	.	PUNCT
admet-2603	9	1	phosphate	phosphate	ADJ
admet-2603	9	2	buffer	buffer	NOUN
admet-2603	9	3	(	(	PUNCT
admet-2603	9	4	ppb	ppb	NOUN
admet-2603	9	5	)	)	PUNCT
admet-2603	9	6	with	with	ADP
admet-2603	9	7	the	the	DET
admet-2603	9	8	same	same	ADJ
admet-2603	9	9	ph	ph	NOUN
admet-2603	9	10	and	and	CCONJ
admet-2603	9	11			NOUN
admet-2603	9	12	was	be	AUX
admet-2603	9	13	used	use	VERB
admet-2603	9	14	for	for	ADP
admet-2603	9	15	comparison	comparison	NOUN
admet-2603	9	16	(	(	PUNCT
admet-2603	9	17	ppb	ppb	NOUN
admet-2603	9	18	=	=	SYM
admet-2603	9	19	8	8	NUM
admet-2603	9	20	mm	mm	NOUN
admet-2603	9	21	)	)	PUNCT
admet-2603	9	22	.	.	PUNCT
admet-2603	10	1	key	key	ADJ
admet-2603	10	2	results	result	NOUN
admet-2603	10	3	:	:	PUNCT
admet-2603	10	4	the	the	DET
admet-2603	10	5	floating	float	VERB
admet-2603	10	6	lid	lid	NOUN
admet-2603	10	7	suppressed	suppress	VERB
admet-2603	10	8	the	the	DET
admet-2603	10	9	ph	ph	ADJ
admet-2603	10	10	increase	increase	NOUN
admet-2603	10	11	to	to	ADP
admet-2603	10	12	less	less	ADJ
admet-2603	10	13	than	than	ADP
admet-2603	10	14	0.1	0.1	NUM
admet-2603	10	15	for	for	ADP
admet-2603	10	16	120	120	NUM
admet-2603	10	17	min	min	NOUN
admet-2603	10	18	.	.	PUNCT
admet-2603	11	1	the	the	DET
admet-2603	11	2	effective	effective	ADJ
admet-2603	11	3	permeability	permeability	NOUN
admet-2603	11	4	(	(	PUNCT
admet-2603	11	5	pe	pe	NOUN
admet-2603	11	6	)	)	PUNCT
admet-2603	11	7	values	value	NOUN
admet-2603	11	8	of	of	ADP
admet-2603	11	9	lipophilic	lipophilic	ADJ
admet-2603	11	10	weakly	weakly	ADJ
admet-2603	11	11	acidic	acidic	ADJ
admet-2603	11	12	and	and	CCONJ
admet-2603	11	13	basic	basic	ADJ
admet-2603	11	14	drugs	drug	NOUN
admet-2603	11	15	were	be	AUX
admet-2603	11	16	lower	low	ADJ
admet-2603	11	17	in	in	ADP
admet-2603	11	18	bcb	bcb	PROPN
admet-2603	11	19	than	than	ADP
admet-2603	11	20	in	in	ADP
admet-2603	11	21	ppb	ppb	NOUN
admet-2603	11	22	(	(	PUNCT
admet-2603	11	23	ketoprofen	ketoprofen	VERB
admet-2603	11	24	,	,	PUNCT
admet-2603	11	25	naproxen	naproxen	NOUN
admet-2603	11	26	,	,	PUNCT
admet-2603	11	27	and	and	CCONJ
admet-2603	11	28	propranolol	propranolol	NOUN
admet-2603	11	29	)	)	PUNCT
admet-2603	11	30	.	.	PUNCT
admet-2603	12	1	on	on	ADP
admet-2603	12	2	the	the	DET
admet-2603	12	3	other	other	ADJ
admet-2603	12	4	hand	hand	NOUN
admet-2603	12	5	,	,	PUNCT
admet-2603	12	6	the	the	DET
admet-2603	12	7	pe	pe	PROPN
admet-2603	12	8	values	value	NOUN
admet-2603	12	9	in	in	ADP
admet-2603	12	10	bcb	bcb	PROPN
admet-2603	12	11	and	and	CCONJ
admet-2603	12	12	ppb	ppb	NOUN
admet-2603	12	13	were	be	AUX
admet-2603	12	14	similar	similar	ADJ
admet-2603	12	15	for	for	ADP
admet-2603	12	16	unionizable	unionizable	ADJ
admet-2603	12	17	drugs	drug	NOUN
admet-2603	12	18	(	(	PUNCT
admet-2603	12	19	caffeine	caffeine	NOUN
admet-2603	12	20	and	and	CCONJ
admet-2603	12	21	antipyrine	antipyrine	VERB
admet-2603	12	22	)	)	PUNCT
admet-2603	12	23	and	and	CCONJ
admet-2603	12	24	hydrophilic	hydrophilic	ADJ
admet-2603	12	25	weakly	weakly	ADJ
admet-2603	12	26	basic	basic	ADJ
admet-2603	12	27	drugs	drug	NOUN
admet-2603	12	28	(	(	PUNCT
admet-2603	12	29	metoprolol	metoprolol	NOUN
admet-2603	12	30	and	and	CCONJ
admet-2603	12	31	procainamide	procainamide	NOUN
admet-2603	12	32	)	)	PUNCT
admet-2603	12	33	.	.	PUNCT
admet-2603	13	1	conclusion	conclusion	NOUN
admet-2603	13	2	:	:	PUNCT
admet-2603	13	3	passive	passive	ADJ
admet-2603	13	4	membrane	membrane	NOUN
admet-2603	13	5	permeation	permeation	NOUN
admet-2603	13	6	of	of	ADP
admet-2603	13	7	lipophilic	lipophilic	ADJ
admet-2603	13	8	weakly	weakly	ADJ
admet-2603	13	9	acidic	acidic	ADJ
admet-2603	13	10	and	and	CCONJ
admet-2603	13	11	basic	basic	ADJ
admet-2603	13	12	drugs	drug	NOUN
admet-2603	13	13	was	be	AUX
admet-2603	13	14	slower	slow	ADJ
admet-2603	13	15	in	in	ADP
admet-2603	13	16	bcb	bcb	PROPN
admet-2603	13	17	than	than	ADP
admet-2603	13	18	in	in	ADP
admet-2603	13	19	ppb	ppb	NOUN
admet-2603	13	20	.	.	PUNCT
admet-2603	14	1	this	this	PRON
admet-2603	14	2	was	be	AUX
admet-2603	14	3	suggested	suggest	VERB
admet-2603	14	4	to	to	PART
admet-2603	14	5	be	be	AUX
admet-2603	14	6	attributed	attribute	VERB
admet-2603	14	7	to	to	ADP
admet-2603	14	8	the	the	DET
admet-2603	14	9	slow	slow	ADJ
admet-2603	14	10	neutralization	neutralization	NOUN
admet-2603	14	11	rate	rate	NOUN
admet-2603	14	12	of	of	ADP
admet-2603	14	13	bcb	bcb	PROPN
admet-2603	14	14	,	,	PUNCT
admet-2603	14	15	which	which	PRON
admet-2603	14	16	affects	affect	VERB
admet-2603	14	17	the	the	DET
admet-2603	14	18	ph	ph	ADJ
admet-2603	14	19	value	value	NOUN
admet-2603	14	20	adjacent	adjacent	ADJ
admet-2603	14	21	to	to	ADP
admet-2603	14	22	the	the	DET
admet-2603	14	23	membrane	membrane	NOUN
admet-2603	14	24	surface	surface	NOUN
admet-2603	14	25	.	.	PUNCT
admet-2603	15	1	©	©	PROPN
admet-2603	15	2	2025	2025	NUM
admet-2603	15	3	by	by	ADP
admet-2603	15	4	the	the	DET
admet-2603	15	5	authors	author	NOUN
admet-2603	15	6	.	.	PUNCT
admet-2603	16	1	this	this	DET
admet-2603	16	2	article	article	NOUN
admet-2603	16	3	is	be	AUX
admet-2603	16	4	an	an	DET
admet-2603	16	5	open	open	ADJ
admet-2603	16	6	-	-	PUNCT
admet-2603	16	7	access	access	NOUN
admet-2603	16	8	article	article	NOUN
admet-2603	16	9	distributed	distribute	VERB
admet-2603	16	10	under	under	ADP
admet-2603	16	11	the	the	DET
admet-2603	16	12	terms	term	NOUN
admet-2603	16	13	and	and	CCONJ
admet-2603	16	14	conditions	condition	NOUN
admet-2603	16	15	of	of	ADP
admet-2603	16	16	the	the	DET
admet-2603	16	17	creative	creative	ADJ
admet-2603	16	18	commons	common	NOUN
admet-2603	16	19	attribution	attribution	NOUN
admet-2603	16	20	license	license	NOUN
admet-2603	16	21	(	(	PUNCT
admet-2603	16	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2603	16	23	)	)	PUNCT
admet-2603	16	24	.	.	PUNCT
admet-2603	17	1	keywords	keyword	VERB
admet-2603	17	2	phosphate	phosphate	ADJ
admet-2603	17	3	buffer	buffer	NOUN
admet-2603	17	4	;	;	PUNCT
admet-2603	17	5	floating	float	VERB
admet-2603	17	6	lid	lid	NOUN
admet-2603	17	7	;	;	PUNCT
admet-2603	17	8	lipophilic	lipophilic	ADJ
admet-2603	17	9	weakly	weakly	ADV
admet-2603	17	10	acidic	acidic	ADJ
admet-2603	17	11	and	and	CCONJ
admet-2603	17	12	basic	basic	ADJ
admet-2603	17	13	drugs	drug	NOUN
admet-2603	17	14	introduction	introduction	NOUN
admet-2603	17	15	it	it	PRON
admet-2603	17	16	is	be	AUX
admet-2603	17	17	important	important	ADJ
admet-2603	17	18	to	to	PART
admet-2603	17	19	assess	assess	VERB
admet-2603	17	20	the	the	DET
admet-2603	17	21	oral	oral	ADJ
admet-2603	17	22	absorption	absorption	NOUN
admet-2603	17	23	of	of	ADP
admet-2603	17	24	a	a	DET
admet-2603	17	25	drug	drug	NOUN
admet-2603	17	26	appropriately	appropriately	ADV
admet-2603	17	27	in	in	ADP
admet-2603	17	28	drug	drug	NOUN
admet-2603	17	29	discovery	discovery	NOUN
admet-2603	17	30	and	and	CCONJ
admet-2603	17	31	development	development	NOUN
admet-2603	17	32	.	.	PUNCT
admet-2603	18	1	the	the	DET
admet-2603	18	2	oral	oral	ADJ
admet-2603	18	3	absorption	absorption	NOUN
admet-2603	18	4	of	of	ADP
admet-2603	18	5	a	a	DET
admet-2603	18	6	drug	drug	NOUN
admet-2603	18	7	is	be	AUX
admet-2603	18	8	mainly	mainly	ADV
admet-2603	18	9	determined	determine	VERB
admet-2603	18	10	by	by	ADP
admet-2603	18	11	the	the	DET
admet-2603	18	12	dissolution	dissolution	NOUN
admet-2603	18	13	and	and	CCONJ
admet-2603	18	14	permeation	permeation	NOUN
admet-2603	18	15	processes	process	NOUN
admet-2603	18	16	in	in	ADP
admet-2603	18	17	the	the	DET
admet-2603	18	18	gastrointestinal	gastrointestinal	ADJ
admet-2603	18	19	(	(	PUNCT
admet-2603	18	20	gi	gi	INTJ
admet-2603	18	21	)	)	PUNCT
admet-2603	18	22	tract	tract	NOUN
admet-2603	18	23	.	.	PUNCT
admet-2603	19	1	these	these	DET
admet-2603	19	2	processes	process	NOUN
admet-2603	19	3	are	be	AUX
admet-2603	19	4	affected	affect	VERB
admet-2603	19	5	by	by	ADP
admet-2603	19	6	various	various	ADJ
admet-2603	19	7	physiological	physiological	ADJ
admet-2603	19	8	gi	gi	NOUN
admet-2603	19	9	conditions	condition	NOUN
admet-2603	19	10	such	such	ADJ
admet-2603	19	11	as	as	ADP
admet-2603	19	12	ph	ph	ADJ
admet-2603	19	13	,	,	PUNCT
admet-2603	19	14	buffer	buffer	NOUN
admet-2603	19	15	species	specie	NOUN
admet-2603	19	16	,	,	PUNCT
admet-2603	19	17	buffer	buffer	NOUN
admet-2603	19	18	capacity	capacity	NOUN
admet-2603	19	19	(	(	PUNCT
admet-2603	19	20			NOUN
admet-2603	19	21	)	)	PUNCT
admet-2603	19	22	,	,	PUNCT
admet-2603	19	23	ionic	ionic	ADJ
admet-2603	19	24	strength	strength	NOUN
admet-2603	19	25	(	(	PUNCT
admet-2603	19	26	i	i	NOUN
admet-2603	19	27	)	)	PUNCT
admet-2603	19	28	,	,	PUNCT
admet-2603	19	29	and	and	CCONJ
admet-2603	19	30	bile	bile	NOUN
admet-2603	19	31	micelle	micelle	NOUN
admet-2603	19	32	concentration	concentration	NOUN
admet-2603	19	33	[	[	X
admet-2603	19	34	1	1	NUM
admet-2603	19	35	]	]	PUNCT
admet-2603	19	36	.	.	PUNCT
admet-2603	20	1	the	the	DET
admet-2603	20	2	ph	ph	ADJ
admet-2603	20	3	value	value	NOUN
admet-2603	20	4	of	of	ADP
admet-2603	20	5	the	the	DET
admet-2603	20	6	intestinal	intestinal	ADJ
admet-2603	20	7	fluid	fluid	NOUN
admet-2603	20	8	is	be	AUX
admet-2603	20	9	physiologically	physiologically	ADV
admet-2603	20	10	maintained	maintain	VERB
admet-2603	20	11	at	at	ADP
admet-2603	20	12	approximately	approximately	ADV
admet-2603	20	13	ph	ph	ADJ
admet-2603	20	14	6.5	6.5	NUM
admet-2603	20	15	by	by	ADP
admet-2603	20	16	bicarbonate	bicarbonate	NOUN
admet-2603	20	17	buffer	buffer	NOUN
admet-2603	20	18	(	(	PUNCT
admet-2603	20	19	bcb	bcb	PROPN
admet-2603	20	20	)	)	PUNCT
admet-2603	20	21	[	[	X
admet-2603	20	22	2,3	2,3	NUM
admet-2603	20	23	]	]	PUNCT
admet-2603	20	24	.	.	PUNCT
admet-2603	21	1	however	however	ADV
admet-2603	21	2	,	,	PUNCT
admet-2603	21	3	for	for	ADP
admet-2603	21	4	practical	practical	ADJ
admet-2603	21	5	reasons	reason	NOUN
admet-2603	21	6	,	,	PUNCT
admet-2603	21	7	phosphate	phosphate	NOUN
admet-2603	21	8	buffer	buffer	NOUN
admet-2603	21	9	(	(	PUNCT
admet-2603	21	10	ppb	ppb	NOUN
admet-2603	21	11	)	)	PUNCT
admet-2603	21	12	and	and	CCONJ
admet-2603	21	13	other	other	ADJ
admet-2603	21	14	buffers	buffer	NOUN
admet-2603	21	15	have	have	AUX
admet-2603	21	16	been	be	AUX
admet-2603	21	17	used	use	VERB
admet-2603	21	18	for	for	ADP
admet-2603	21	19	a	a	DET
admet-2603	21	20	variety	variety	NOUN
admet-2603	21	21	of	of	ADP
admet-2603	21	22	in	in	ADP
admet-2603	21	23	vitro	vitro	X
admet-2603	21	24	assays	assay	NOUN
admet-2603	21	25	in	in	ADP
admet-2603	21	26	drug	drug	NOUN
admet-2603	21	27	discovery	discovery	NOUN
admet-2603	21	28	and	and	CCONJ
admet-2603	21	29	drug	drug	NOUN
admet-2603	21	30	development	development	NOUN
admet-2603	21	31	[	[	X
admet-2603	21	32	4	4	NUM
admet-2603	21	33	]	]	PUNCT
admet-2603	21	34	.	.	PUNCT
admet-2603	22	1	biorelevant	biorelevant	PROPN
admet-2603	22	2	dissolution	dissolution	NOUN
admet-2603	22	3	tests	test	NOUN
admet-2603	22	4	using	use	VERB
admet-2603	22	5	bcb	bcb	PROPN
admet-2603	22	6	have	have	AUX
admet-2603	22	7	been	be	AUX
admet-2603	22	8	explored	explore	VERB
admet-2603	22	9	over	over	ADP
admet-2603	22	10	the	the	DET
admet-2603	22	11	past	past	ADJ
admet-2603	22	12	two	two	NUM
admet-2603	22	13	decades	decade	NOUN
admet-2603	22	14	.	.	PUNCT
admet-2603	23	1	the	the	DET
admet-2603	23	2	ph	ph	ADJ
admet-2603	23	3	value	value	NOUN
admet-2603	23	4	of	of	ADP
admet-2603	23	5	bcb	bcb	PROPN
admet-2603	23	6	rapidly	rapidly	ADV
admet-2603	23	7	increases	increase	VERB
admet-2603	23	8	as	as	SCONJ
admet-2603	23	9	co2	co2	NOUN
admet-2603	23	10	escapes	escape	VERB
admet-2603	23	11	via	via	ADP
admet-2603	23	12	the	the	DET
admet-2603	23	13	air	air	NOUN
admet-2603	23	14	-	-	PUNCT
admet-2603	23	15	solution	solution	NOUN
admet-2603	23	16	interface	interface	NOUN
admet-2603	23	17	.	.	PUNCT
admet-2603	24	1	previously	previously	ADV
admet-2603	24	2	,	,	PUNCT
admet-2603	24	3	the	the	DET
admet-2603	24	4	co2	co2	NOUN
admet-2603	24	5	charging	charging	NOUN
admet-2603	24	6	methods	method	NOUN
admet-2603	24	7	have	have	AUX
admet-2603	24	8	been	be	AUX
admet-2603	24	9	used	use	VERB
admet-2603	24	10	to	to	PART
admet-2603	24	11	maintain	maintain	VERB
admet-2603	24	12	the	the	DET
admet-2603	24	13	ph	ph	ADJ
admet-2603	24	14	value	value	NOUN
admet-2603	24	15	of	of	ADP
admet-2603	24	16	bcb	bcb	PROPN
admet-2603	25	1	[	[	X
admet-2603	25	2	5	5	NUM
admet-2603	25	3	-	-	SYM
admet-2603	25	4	8	8	NUM
admet-2603	25	5	]	]	PUNCT
admet-2603	25	6	.	.	PUNCT
admet-2603	26	1	however	however	ADV
admet-2603	26	2	,	,	PUNCT
admet-2603	26	3	these	these	DET
admet-2603	26	4	sophisticated	sophisticated	ADJ
admet-2603	26	5	methods	method	NOUN
admet-2603	26	6	have	have	VERB
admet-2603	26	7	some	some	DET
admet-2603	26	8	inherent	inherent	ADJ
admet-2603	26	9	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	26	10	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	26	11	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2603	26	12	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	PROPN
admet-2603	27	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2603	27	2	s.	s.	PROPN
admet-2603	27	3	ishida	ishida	PROPN
admet-2603	27	4	et	et	PROPN
admet-2603	27	5	al	al	PROPN
admet-2603	27	6	.	.	PROPN
admet-2603	27	7	admet	admet	PROPN
admet-2603	27	8	&	&	CCONJ
admet-2603	27	9	dmpk	dmpk	PROPN
admet-2603	27	10	13(1	13(1	NUM
admet-2603	27	11	)	)	PUNCT
admet-2603	27	12	(	(	PUNCT
admet-2603	27	13	2025	2025	NUM
admet-2603	27	14	)	)	PUNCT
admet-2603	27	15	2603	2603	NUM
admet-2603	27	16	2	2	NUM
admet-2603	27	17	limitations	limitation	NOUN
admet-2603	27	18	that	that	PRON
admet-2603	27	19	might	might	AUX
admet-2603	27	20	have	have	AUX
admet-2603	27	21	limited	limit	VERB
admet-2603	27	22	the	the	DET
admet-2603	27	23	use	use	NOUN
admet-2603	27	24	of	of	ADP
admet-2603	27	25	bcb	bcb	PROPN
admet-2603	27	26	in	in	ADP
admet-2603	27	27	drug	drug	NOUN
admet-2603	27	28	discovery	discovery	NOUN
admet-2603	27	29	and	and	CCONJ
admet-2603	27	30	development	development	NOUN
admet-2603	27	31	[	[	X
admet-2603	27	32	4	4	NUM
admet-2603	27	33	]	]	PUNCT
admet-2603	27	34	.	.	PUNCT
admet-2603	28	1	recently	recently	ADV
admet-2603	28	2	,	,	PUNCT
admet-2603	28	3	the	the	DET
admet-2603	28	4	floating	float	VERB
admet-2603	28	5	lid	lid	NOUN
admet-2603	28	6	method	method	NOUN
admet-2603	28	7	has	have	AUX
admet-2603	28	8	been	be	AUX
admet-2603	28	9	introduced	introduce	VERB
admet-2603	28	10	as	as	ADP
admet-2603	28	11	a	a	DET
admet-2603	28	12	simple	simple	ADJ
admet-2603	28	13	,	,	PUNCT
admet-2603	28	14	robust	robust	ADJ
admet-2603	28	15	,	,	PUNCT
admet-2603	28	16	and	and	CCONJ
admet-2603	28	17	versatile	versatile	ADJ
admet-2603	28	18	way	way	NOUN
admet-2603	28	19	to	to	PART
admet-2603	28	20	maintain	maintain	VERB
admet-2603	28	21	the	the	DET
admet-2603	28	22	ph	ph	ADJ
admet-2603	28	23	value	value	NOUN
admet-2603	28	24	of	of	ADP
admet-2603	28	25	bcb	bcb	PROPN
admet-2603	29	1	[	[	X
admet-2603	29	2	9	9	NUM
admet-2603	29	3	]	]	PUNCT
admet-2603	29	4	.	.	PUNCT
admet-2603	30	1	the	the	DET
admet-2603	30	2	floating	float	VERB
admet-2603	30	3	lid	lid	NOUN
admet-2603	30	4	method	method	NOUN
admet-2603	30	5	has	have	AUX
admet-2603	30	6	already	already	ADV
admet-2603	30	7	been	be	AUX
admet-2603	30	8	applied	apply	VERB
admet-2603	30	9	to	to	PART
admet-2603	30	10	compendial	compendial	VERB
admet-2603	30	11	dissolution	dissolution	NOUN
admet-2603	30	12	vessels	vessel	NOUN
admet-2603	30	13	[	[	X
admet-2603	30	14	9	9	NUM
admet-2603	30	15	]	]	PUNCT
admet-2603	30	16	,	,	PUNCT
admet-2603	30	17	a	a	DET
admet-2603	30	18	mini	mini	ADJ
admet-2603	30	19	-	-	NOUN
admet-2603	30	20	scale	scale	ADJ
admet-2603	30	21	vessel	vessel	NOUN
admet-2603	31	1	[	[	X
admet-2603	31	2	10	10	NUM
admet-2603	31	3	]	]	PUNCT
admet-2603	31	4	,	,	PUNCT
admet-2603	31	5	and	and	CCONJ
admet-2603	31	6	a	a	DET
admet-2603	31	7	flow	flow	NOUN
admet-2603	31	8	-	-	PUNCT
admet-2603	31	9	through	through	ADP
admet-2603	31	10	system	system	NOUN
admet-2603	31	11	[	[	X
admet-2603	31	12	11	11	NUM
admet-2603	31	13	]	]	PUNCT
admet-2603	31	14	.	.	PUNCT
admet-2603	32	1	bcb	bcb	PROPN
admet-2603	32	2	has	have	VERB
admet-2603	32	3	a	a	DET
admet-2603	32	4	slower	slow	ADJ
admet-2603	32	5	ph	ph	NOUN
admet-2603	32	6	neutralization	neutralization	NOUN
admet-2603	32	7	rate	rate	NOUN
admet-2603	32	8	due	due	ADP
admet-2603	32	9	to	to	ADP
admet-2603	32	10	the	the	DET
admet-2603	32	11	slow	slow	ADJ
admet-2603	32	12	co2	co2	NOUN
admet-2603	32	13	to	to	PART
admet-2603	32	14	h2co3	h2co3	VERB
admet-2603	32	15	hydration	hydration	NOUN
admet-2603	32	16	/	/	SYM
admet-2603	32	17	dehydration	dehydration	NOUN
admet-2603	32	18	processes	process	NOUN
admet-2603	32	19	[	[	X
admet-2603	32	20	12,13	12,13	NUM
admet-2603	32	21	]	]	PUNCT
admet-2603	32	22	.	.	PUNCT
admet-2603	33	1	co2	co2	NOUN
admet-2603	33	2	+	+	CCONJ
admet-2603	33	3	h2o	h2o	PROPN
admet-2603	33	4	⇌	⇌	PROPN
admet-2603	33	5	h2co3	h2co3	VERB
admet-2603	33	6	⇌	⇌	PROPN
admet-2603	33	7	hco3	hco3	PROPN
admet-2603	33	8	+	+	CCONJ
admet-2603	33	9	h+	h+	X
admet-2603	33	10	(	(	PUNCT
admet-2603	33	11	1	1	X
admet-2603	33	12	)	)	PUNCT
admet-2603	33	13	this	this	PRON
admet-2603	33	14	affects	affect	VERB
admet-2603	33	15	the	the	DET
admet-2603	33	16	particle	particle	NOUN
admet-2603	33	17	surface	surface	NOUN
admet-2603	33	18	ph	ph	PROPN
admet-2603	33	19	(	(	PUNCT
admet-2603	33	20	phps	phps	PROPN
admet-2603	33	21	)	)	PUNCT
admet-2603	33	22	of	of	ADP
admet-2603	33	23	ionizable	ionizable	ADJ
admet-2603	33	24	drugs	drug	NOUN
admet-2603	33	25	dissolving	dissolve	VERB
admet-2603	33	26	(	(	PUNCT
admet-2603	33	27	and	and	CCONJ
admet-2603	33	28	precipitating	precipitate	VERB
admet-2603	33	29	)	)	PUNCT
admet-2603	33	30	in	in	ADP
admet-2603	33	31	bcb	bcb	PROPN
admet-2603	34	1	[	[	X
admet-2603	34	2	5,12	5,12	NUM
admet-2603	34	3	-	-	SYM
admet-2603	34	4	17	17	NUM
admet-2603	34	5	]	]	PUNCT
admet-2603	34	6	.	.	PUNCT
admet-2603	35	1	in	in	ADP
admet-2603	35	2	addition	addition	NOUN
admet-2603	35	3	,	,	PUNCT
admet-2603	35	4	the	the	DET
admet-2603	35	5	change	change	NOUN
admet-2603	35	6	of	of	ADP
admet-2603	35	7	bulk	bulk	ADJ
admet-2603	35	8	phase	phase	NOUN
admet-2603	35	9	ph	ph	NOUN
admet-2603	35	10	(	(	PUNCT
admet-2603	35	11	phbulk	phbulk	ADJ
admet-2603	35	12	)	)	PUNCT
admet-2603	35	13	after	after	ADP
admet-2603	35	14	the	the	DET
admet-2603	35	15	dissolution	dissolution	NOUN
admet-2603	35	16	of	of	ADP
admet-2603	35	17	ionizable	ionizable	ADJ
admet-2603	35	18	drugs	drug	NOUN
admet-2603	35	19	can	can	AUX
admet-2603	35	20	also	also	ADV
admet-2603	35	21	be	be	AUX
admet-2603	35	22	different	different	ADJ
admet-2603	35	23	between	between	ADP
admet-2603	35	24	bcb	bcb	PROPN
admet-2603	35	25	and	and	CCONJ
admet-2603	35	26	ppb	ppb	NOUN
admet-2603	35	27	,	,	PUNCT
admet-2603	35	28	even	even	ADV
admet-2603	35	29	when	when	SCONJ
admet-2603	35	30	the	the	DET
admet-2603	35	31			PROPN
admet-2603	35	32	values	value	NOUN
admet-2603	35	33	are	be	AUX
admet-2603	35	34	set	set	VERB
admet-2603	35	35	to	to	PART
admet-2603	35	36	be	be	AUX
admet-2603	35	37	the	the	DET
admet-2603	35	38	same	same	ADJ
admet-2603	35	39	[	[	X
admet-2603	35	40	18,19	18,19	NUM
admet-2603	35	41	]	]	PUNCT
admet-2603	35	42	.	.	PUNCT
admet-2603	36	1	the	the	DET
admet-2603	36	2	pka	pka	PROPN
admet-2603	36	3	values	value	NOUN
admet-2603	36	4	of	of	ADP
admet-2603	36	5	bcb	bcb	PROPN
admet-2603	36	6	and	and	CCONJ
admet-2603	36	7	ppb	ppb	NOUN
admet-2603	36	8	are	be	AUX
admet-2603	36	9	lower	low	ADJ
admet-2603	36	10	and	and	CCONJ
admet-2603	36	11	higher	high	ADJ
admet-2603	36	12	than	than	ADP
admet-2603	36	13	6.5	6.5	NUM
admet-2603	36	14	,	,	PUNCT
admet-2603	36	15	respectively	respectively	ADV
admet-2603	36	16	(	(	PUNCT
admet-2603	36	17	bcb	bcb	PROPN
admet-2603	36	18	:	:	PUNCT
admet-2603	36	19	pka	pka	PROPN
admet-2603	36	20	=	=	PROPN
admet-2603	36	21	6.05	6.05	NUM
admet-2603	36	22	,	,	PUNCT
admet-2603	36	23	ppb	ppb	NOUN
admet-2603	36	24	:	:	PUNCT
admet-2603	36	25	pka	pka	NOUN
admet-2603	36	26	=	=	NOUN
admet-2603	36	27	6.69	6.69	NUM
admet-2603	36	28	,	,	PUNCT
admet-2603	36	29	37	37	NUM
admet-2603	36	30	°	°	NOUN
admet-2603	36	31	c	c	NOUN
admet-2603	36	32	,	,	PUNCT
admet-2603	36	33	ionic	ionic	ADJ
admet-2603	36	34	strength	strength	NOUN
admet-2603	36	35	(	(	PUNCT
admet-2603	36	36	i	i	NOUN
admet-2603	36	37	)	)	PUNCT
admet-2603	36	38	=	=	PUNCT
admet-2603	36	39	0.15	0.15	NUM
admet-2603	36	40	m	m	NOUN
admet-2603	36	41	)	)	PUNCT
admet-2603	37	1	[	[	X
admet-2603	37	2	20	20	NUM
admet-2603	37	3	]	]	PUNCT
admet-2603	37	4	.	.	PUNCT
admet-2603	38	1	therefore	therefore	ADV
admet-2603	38	2	,	,	PUNCT
admet-2603	38	3	the	the	DET
admet-2603	38	4	phbulk	phbulk	ADJ
admet-2603	38	5	value	value	NOUN
admet-2603	38	6	is	be	AUX
admet-2603	38	7	less	less	ADV
admet-2603	38	8	reduced	reduce	VERB
admet-2603	38	9	by	by	ADP
admet-2603	38	10	the	the	DET
admet-2603	38	11	addition	addition	NOUN
admet-2603	38	12	of	of	ADP
admet-2603	38	13	a	a	DET
admet-2603	38	14	free	free	ADJ
admet-2603	38	15	weak	weak	ADJ
admet-2603	38	16	acid	acid	NOUN
admet-2603	38	17	or	or	CCONJ
admet-2603	38	18	a	a	DET
admet-2603	38	19	salt	salt	NOUN
admet-2603	38	20	of	of	ADP
admet-2603	38	21	a	a	DET
admet-2603	38	22	weak	weak	ADJ
admet-2603	38	23	base	base	NOUN
admet-2603	38	24	in	in	ADP
admet-2603	38	25	bcb	bcb	PROPN
admet-2603	38	26	than	than	ADP
admet-2603	38	27	in	in	ADP
admet-2603	38	28	ppb	ppb	NOUN
admet-2603	38	29	[	[	X
admet-2603	38	30	18,19	18,19	NUM
admet-2603	38	31	]	]	PUNCT
admet-2603	38	32	.	.	PUNCT
admet-2603	39	1	these	these	DET
admet-2603	39	2	features	feature	NOUN
admet-2603	39	3	of	of	ADP
admet-2603	39	4	bcb	bcb	PROPN
admet-2603	39	5	can	can	AUX
admet-2603	39	6	significantly	significantly	ADV
admet-2603	39	7	affect	affect	VERB
admet-2603	39	8	the	the	DET
admet-2603	39	9	dissolution	dissolution	ADJ
admet-2603	39	10	profiles	profile	NOUN
admet-2603	39	11	of	of	ADP
admet-2603	39	12	various	various	ADJ
admet-2603	39	13	drugs	drug	NOUN
admet-2603	39	14	.	.	PUNCT
admet-2603	40	1	the	the	DET
admet-2603	40	2	dissolution	dissolution	ADJ
admet-2603	40	3	profiles	profile	NOUN
admet-2603	40	4	of	of	ADP
admet-2603	40	5	free	free	ADJ
admet-2603	40	6	-	-	PUNCT
admet-2603	40	7	form	form	NOUN
admet-2603	40	8	weakly	weakly	ADJ
admet-2603	40	9	acidic	acidic	ADJ
admet-2603	40	10	and	and	CCONJ
admet-2603	40	11	weakly	weakly	ADJ
admet-2603	40	12	basic	basic	ADJ
admet-2603	40	13	drugs	drug	NOUN
admet-2603	40	14	were	be	AUX
admet-2603	40	15	reported	report	VERB
admet-2603	40	16	to	to	PART
admet-2603	40	17	be	be	AUX
admet-2603	40	18	slower	slow	ADJ
admet-2603	40	19	in	in	ADP
admet-2603	40	20	bcb	bcb	PROPN
admet-2603	40	21	than	than	ADP
admet-2603	40	22	in	in	ADP
admet-2603	40	23	ppb	ppb	NOUN
admet-2603	40	24	due	due	ADP
admet-2603	40	25	to	to	ADP
admet-2603	40	26	the	the	DET
admet-2603	40	27	difference	difference	NOUN
admet-2603	40	28	in	in	ADP
admet-2603	40	29	phps	phps	PROPN
admet-2603	41	1	[	[	X
admet-2603	41	2	5,12	5,12	NUM
admet-2603	41	3	-	-	SYM
admet-2603	41	4	15	15	NUM
admet-2603	41	5	]	]	PUNCT
admet-2603	41	6	.	.	PUNCT
admet-2603	42	1	recently	recently	ADV
admet-2603	42	2	,	,	PUNCT
admet-2603	42	3	the	the	DET
admet-2603	42	4	dissolution	dissolution	ADJ
admet-2603	42	5	profiles	profile	NOUN
admet-2603	42	6	of	of	ADP
admet-2603	42	7	salt	salt	NOUN
admet-2603	42	8	-	-	PUNCT
admet-2603	42	9	form	form	NOUN
admet-2603	42	10	drug	drug	NOUN
admet-2603	42	11	substances	substance	NOUN
admet-2603	42	12	were	be	AUX
admet-2603	42	13	found	find	VERB
admet-2603	42	14	to	to	PART
admet-2603	42	15	differ	differ	VERB
admet-2603	42	16	markedly	markedly	ADV
admet-2603	42	17	between	between	ADP
admet-2603	42	18	bcb	bcb	PROPN
admet-2603	42	19	and	and	CCONJ
admet-2603	42	20	ppb	ppb	NOUN
admet-2603	42	21	due	due	ADP
admet-2603	42	22	to	to	ADP
admet-2603	42	23	the	the	DET
admet-2603	42	24	difference	difference	NOUN
admet-2603	42	25	in	in	ADP
admet-2603	42	26	phps	phps	PROPN
admet-2603	43	1	[	[	X
admet-2603	43	2	16,21	16,21	X
admet-2603	43	3	]	]	PUNCT
admet-2603	43	4	and	and	CCONJ
admet-2603	43	5	phbulk	phbulk	ADJ
admet-2603	44	1	[	[	X
admet-2603	44	2	19	19	NUM
admet-2603	44	3	]	]	PUNCT
admet-2603	44	4	.	.	PUNCT
admet-2603	45	1	the	the	DET
admet-2603	45	2	crystalline	crystalline	ADJ
admet-2603	45	3	precipitation	precipitation	NOUN
admet-2603	45	4	of	of	ADP
admet-2603	45	5	weakly	weakly	ADJ
admet-2603	45	6	acidic	acidic	ADJ
admet-2603	45	7	and	and	CCONJ
admet-2603	45	8	basic	basic	ADJ
admet-2603	45	9	drugs	drug	NOUN
admet-2603	45	10	can	can	AUX
admet-2603	45	11	be	be	AUX
admet-2603	45	12	markedly	markedly	ADV
admet-2603	45	13	slower	slow	ADJ
admet-2603	45	14	in	in	ADP
admet-2603	45	15	bcb	bcb	PROPN
admet-2603	45	16	than	than	ADP
admet-2603	45	17	in	in	ADP
admet-2603	45	18	ppb	ppb	NOUN
admet-2603	45	19	[	[	X
admet-2603	45	20	17	17	NUM
admet-2603	45	21	]	]	PUNCT
admet-2603	45	22	.	.	PUNCT
admet-2603	46	1	furthermore	furthermore	ADV
admet-2603	46	2	,	,	PUNCT
admet-2603	46	3	the	the	DET
admet-2603	46	4	dissolution	dissolution	ADJ
admet-2603	46	5	profiles	profile	NOUN
admet-2603	46	6	of	of	ADP
admet-2603	46	7	many	many	ADJ
admet-2603	46	8	immediate	immediate	ADJ
admet-2603	46	9	-	-	PUNCT
admet-2603	46	10	release	release	NOUN
admet-2603	46	11	drug	drug	NOUN
admet-2603	46	12	products	product	NOUN
admet-2603	46	13	were	be	AUX
admet-2603	46	14	markedly	markedly	ADV
admet-2603	46	15	different	different	ADJ
admet-2603	46	16	between	between	ADP
admet-2603	46	17	bcb	bcb	PROPN
admet-2603	46	18	and	and	CCONJ
admet-2603	46	19	ppb	ppb	VERB
admet-2603	47	1	[	[	X
admet-2603	47	2	19,22	19,22	X
admet-2603	47	3	]	]	X
admet-2603	47	4	.	.	PUNCT
admet-2603	48	1	the	the	DET
admet-2603	48	2	use	use	NOUN
admet-2603	48	3	of	of	ADP
admet-2603	48	4	bcb	bcb	PROPN
admet-2603	48	5	in	in	ADP
admet-2603	48	6	dissolution	dissolution	ADJ
admet-2603	48	7	tests	test	NOUN
admet-2603	48	8	was	be	AUX
admet-2603	48	9	suggested	suggest	VERB
admet-2603	48	10	to	to	PART
admet-2603	48	11	be	be	AUX
admet-2603	48	12	critically	critically	ADV
admet-2603	48	13	important	important	ADJ
admet-2603	48	14	for	for	ADP
admet-2603	48	15	the	the	DET
admet-2603	48	16	assessment	assessment	NOUN
admet-2603	48	17	of	of	ADP
admet-2603	48	18	bioequivalence	bioequivalence	NOUN
admet-2603	48	19	in	in	ADP
admet-2603	48	20	generic	generic	ADJ
admet-2603	48	21	drug	drug	NOUN
admet-2603	48	22	development	development	NOUN
admet-2603	49	1	[	[	X
admet-2603	49	2	11,23	11,23	NUM
admet-2603	49	3	-	-	SYM
admet-2603	49	4	25	25	NUM
admet-2603	49	5	]	]	PUNCT
admet-2603	49	6	.	.	PUNCT
admet-2603	50	1	however	however	ADV
admet-2603	50	2	,	,	PUNCT
admet-2603	50	3	to	to	ADP
admet-2603	50	4	the	the	DET
admet-2603	50	5	best	good	ADJ
admet-2603	50	6	of	of	ADP
admet-2603	50	7	our	our	PRON
admet-2603	50	8	knowledge	knowledge	NOUN
admet-2603	50	9	,	,	PUNCT
admet-2603	50	10	the	the	DET
admet-2603	50	11	effect	effect	NOUN
admet-2603	50	12	of	of	ADP
admet-2603	50	13	bcb	bcb	PROPN
admet-2603	50	14	on	on	ADP
admet-2603	50	15	the	the	DET
admet-2603	50	16	membrane	membrane	NOUN
admet-2603	50	17	permeation	permeation	NOUN
admet-2603	50	18	process	process	NOUN
admet-2603	50	19	has	have	AUX
admet-2603	50	20	not	not	PART
admet-2603	50	21	been	be	AUX
admet-2603	50	22	investigated	investigate	VERB
admet-2603	50	23	.	.	PUNCT
admet-2603	51	1	the	the	DET
admet-2603	51	2	purpose	purpose	NOUN
admet-2603	51	3	of	of	ADP
admet-2603	51	4	the	the	DET
admet-2603	51	5	present	present	ADJ
admet-2603	51	6	study	study	NOUN
admet-2603	51	7	was	be	AUX
admet-2603	51	8	to	to	PART
admet-2603	51	9	investigate	investigate	VERB
admet-2603	51	10	the	the	DET
admet-2603	51	11	effect	effect	NOUN
admet-2603	51	12	of	of	ADP
admet-2603	51	13	bcb	bcb	PROPN
admet-2603	51	14	and	and	CCONJ
admet-2603	51	15	ppb	ppb	VERB
admet-2603	51	16	on	on	ADP
admet-2603	51	17	the	the	DET
admet-2603	51	18	passive	passive	ADJ
admet-2603	51	19	membrane	membrane	NOUN
admet-2603	51	20	permeation	permeation	NOUN
admet-2603	51	21	of	of	ADP
admet-2603	51	22	drugs	drug	NOUN
admet-2603	51	23	.	.	PUNCT
admet-2603	52	1	in	in	ADP
admet-2603	52	2	this	this	DET
admet-2603	52	3	study	study	NOUN
admet-2603	52	4	,	,	PUNCT
admet-2603	52	5	three	three	NUM
admet-2603	52	6	weakly	weakly	ADJ
admet-2603	52	7	acidic	acidic	ADJ
admet-2603	52	8	drugs	drug	NOUN
admet-2603	52	9	,	,	PUNCT
admet-2603	52	10	three	three	NUM
admet-2603	52	11	weakly	weakly	ADJ
admet-2603	52	12	basic	basic	ADJ
admet-2603	52	13	drugs	drug	NOUN
admet-2603	52	14	,	,	PUNCT
admet-2603	52	15	and	and	CCONJ
admet-2603	52	16	two	two	NUM
admet-2603	52	17	neutral	neutral	ADJ
admet-2603	52	18	drugs	drug	NOUN
admet-2603	52	19	were	be	AUX
admet-2603	52	20	used	use	VERB
admet-2603	52	21	as	as	ADP
admet-2603	52	22	model	model	NOUN
admet-2603	52	23	drugs	drug	NOUN
admet-2603	52	24	(	(	PUNCT
admet-2603	52	25	table	table	NOUN
admet-2603	52	26	1	1	NUM
admet-2603	52	27	)	)	PUNCT
admet-2603	52	28	.	.	PUNCT
admet-2603	53	1	the	the	DET
admet-2603	53	2	μflux	μflux	NOUN
admet-2603	53	3	apparatus	apparatus	NOUN
admet-2603	53	4	(	(	PUNCT
admet-2603	53	5	pion	pion	PROPN
admet-2603	53	6	inc	inc	PROPN
admet-2603	53	7	.	.	PROPN
admet-2603	53	8	)	)	PUNCT
admet-2603	53	9	was	be	AUX
admet-2603	53	10	used	use	VERB
admet-2603	53	11	for	for	ADP
admet-2603	53	12	permeability	permeability	NOUN
admet-2603	53	13	measurements	measurement	NOUN
admet-2603	53	14	.	.	PUNCT
admet-2603	54	1	a	a	DET
admet-2603	54	2	floating	float	VERB
admet-2603	54	3	lid	lid	NOUN
admet-2603	54	4	was	be	AUX
admet-2603	54	5	newly	newly	ADV
admet-2603	54	6	developed	develop	VERB
admet-2603	54	7	for	for	ADP
admet-2603	54	8	μflux	μflux	NOUN
admet-2603	54	9	(	(	PUNCT
admet-2603	54	10	figure	figure	NOUN
admet-2603	54	11	1	1	NUM
admet-2603	54	12	)	)	PUNCT
admet-2603	55	1	[	[	X
admet-2603	55	2	9	9	NUM
admet-2603	55	3	]	]	PUNCT
admet-2603	55	4	.	.	PUNCT
admet-2603	56	1	bcb	bcb	PROPN
admet-2603	56	2	condition	condition	NOUN
admet-2603	56	3	was	be	AUX
admet-2603	56	4	set	set	VERB
admet-2603	56	5	to	to	PART
admet-2603	56	6	be	be	AUX
admet-2603	56	7	relevant	relevant	ADJ
admet-2603	56	8	to	to	ADP
admet-2603	56	9	the	the	DET
admet-2603	56	10	human	human	ADJ
admet-2603	56	11	small	small	ADJ
admet-2603	56	12	intestine	intestine	NOUN
admet-2603	56	13	(	(	PUNCT
admet-2603	56	14	ph	ph	PROPN
admet-2603	56	15	6.5	6.5	NUM
admet-2603	56	16	,	,	PUNCT
admet-2603	56	17	bcb	bcb	PROPN
admet-2603	56	18	=	=	PROPN
admet-2603	56	19	10	10	NUM
admet-2603	56	20	mm	mm	NOUN
admet-2603	56	21	,	,	PUNCT
admet-2603	56	22	i	i	NOUN
admet-2603	56	23	=	=	PROPN
admet-2603	56	24	0.14	0.14	NUM
admet-2603	56	25	m	m	NOUN
admet-2603	56	26	)	)	PUNCT
admet-2603	57	1	[	[	X
admet-2603	57	2	2,3	2,3	NUM
admet-2603	57	3	]	]	PUNCT
admet-2603	57	4	.	.	PUNCT
admet-2603	58	1	the	the	DET
admet-2603	58	2	μflux	μflux	PROPN
admet-2603	58	3	experiment	experiment	NOUN
admet-2603	58	4	used	use	VERB
admet-2603	58	5	an	an	DET
admet-2603	58	6	artificial	artificial	ADJ
admet-2603	58	7	membrane	membrane	NOUN
admet-2603	58	8	composed	compose	VERB
admet-2603	58	9	of	of	ADP
admet-2603	58	10	phospholipids	phospholipid	NOUN
admet-2603	58	11	and	and	CCONJ
admet-2603	58	12	an	an	DET
admet-2603	58	13	organic	organic	ADJ
admet-2603	58	14	solvent	solvent	NOUN
admet-2603	58	15	,	,	PUNCT
admet-2603	58	16	the	the	DET
admet-2603	58	17	same	same	ADJ
admet-2603	58	18	as	as	ADP
admet-2603	58	19	in	in	ADP
admet-2603	58	20	the	the	DET
admet-2603	58	21	parallel	parallel	ADJ
admet-2603	58	22	artificial	artificial	ADJ
admet-2603	58	23	membrane	membrane	NOUN
admet-2603	58	24	permeabilization	permeabilization	NOUN
admet-2603	58	25	assay	assay	NOUN
admet-2603	58	26	(	(	PUNCT
admet-2603	58	27	pampa	pampa	PROPN
admet-2603	58	28	)	)	PUNCT
admet-2603	58	29	.	.	PUNCT
admet-2603	59	1	pampa	pampa	PROPN
admet-2603	59	2	has	have	AUX
admet-2603	59	3	been	be	AUX
admet-2603	59	4	widely	widely	ADV
admet-2603	59	5	used	use	VERB
admet-2603	59	6	to	to	PART
admet-2603	59	7	assess	assess	VERB
admet-2603	59	8	the	the	DET
admet-2603	59	9	passive	passive	ADJ
admet-2603	59	10	membrane	membrane	NOUN
admet-2603	59	11	permeation	permeation	NOUN
admet-2603	59	12	of	of	ADP
admet-2603	59	13	drugs	drug	NOUN
admet-2603	59	14	in	in	ADP
admet-2603	59	15	drug	drug	NOUN
admet-2603	59	16	discovery	discovery	NOUN
admet-2603	59	17	and	and	CCONJ
admet-2603	59	18	development	development	NOUN
admet-2603	60	1	[	[	X
admet-2603	60	2	26,27	26,27	NUM
admet-2603	60	3	]	]	PUNCT
admet-2603	60	4	.	.	PUNCT
admet-2603	61	1	a	a	DET
admet-2603	61	2	b	b	NUM
admet-2603	61	3	figure	figure	NOUN
admet-2603	61	4	1	1	NUM
admet-2603	61	5	.	.	PUNCT
admet-2603	61	6	flux	flux	NOUN
admet-2603	61	7	apparatus	apparatus	NOUN
admet-2603	61	8	with	with	ADP
admet-2603	61	9	floating	float	VERB
admet-2603	61	10	lids	lid	NOUN
admet-2603	61	11	(	(	PUNCT
admet-2603	61	12	a	a	NOUN
admet-2603	61	13	)	)	PUNCT
admet-2603	61	14	and	and	CCONJ
admet-2603	61	15	the	the	DET
admet-2603	61	16	picture	picture	NOUN
admet-2603	61	17	of	of	ADP
admet-2603	61	18	the	the	DET
admet-2603	61	19	floating	float	VERB
admet-2603	61	20	lid	lid	NOUN
admet-2603	61	21	(	(	PUNCT
admet-2603	61	22	b	b	NOUN
admet-2603	61	23	)	)	PUNCT
admet-2603	61	24	admet	admet	PROPN
admet-2603	61	25	&	&	CCONJ
admet-2603	61	26	dmpk	dmpk	PROPN
admet-2603	61	27	13(1	13(1	NUM
admet-2603	61	28	)	)	PUNCT
admet-2603	61	29	(	(	PUNCT
admet-2603	61	30	2025	2025	NUM
admet-2603	61	31	)	)	PUNCT
admet-2603	61	32	2603	2603	NUM
admet-2603	61	33	effect	effect	NOUN
admet-2603	61	34	of	of	ADP
admet-2603	61	35	bicarbonate	bicarbonate	NOUN
admet-2603	61	36	buffer	buffer	NOUN
admet-2603	61	37	on	on	ADP
admet-2603	61	38	artificial	artificial	ADJ
admet-2603	61	39	membrane	membrane	NOUN
admet-2603	61	40	permeation	permeation	NOUN
admet-2603	61	41	of	of	ADP
admet-2603	61	42	drugs	drug	NOUN
admet-2603	61	43	doi	doi	PROPN
admet-2603	61	44	:	:	PUNCT
admet-2603	61	45	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	61	46	3	3	NUM
admet-2603	61	47	table	table	NOUN
admet-2603	61	48	1	1	NUM
admet-2603	61	49	.	.	PUNCT
admet-2603	61	50	physicochemical	physicochemical	ADJ
admet-2603	61	51	properties	property	NOUN
admet-2603	61	52	of	of	ADP
admet-2603	61	53	model	model	NOUN
admet-2603	61	54	drugs	drug	NOUN
admet-2603	61	55	drug	drug	NOUN
admet-2603	61	56	name	name	NOUN
admet-2603	61	57	mw	mw	AUX
admet-2603	61	58	log	log	PROPN
admet-2603	61	59	poct	poct	NOUN
admet-2603	61	60	a	a	DET
admet-2603	61	61	pka	pka	PROPN
admet-2603	61	62	a	a	DET
admet-2603	61	63	log	log	NOUN
admet-2603	61	64	doct	doct	NOUN
admet-2603	61	65	(	(	PUNCT
admet-2603	61	66	ph	ph	PROPN
admet-2603	61	67	6.5)d	6.5)d	PROPN
admet-2603	61	68	dmono	dmono	NOUN
admet-2603	61	69	/	/	SYM
admet-2603	61	70	10	10	NUM
admet-2603	61	71	-	-	SYM
admet-2603	61	72	6	6	NUM
admet-2603	61	73	cm2	cm2	NOUN
admet-2603	61	74	s-1e	s-1e	NOUN
admet-2603	61	75	uv	uv	NOUN
admet-2603	61	76	detection	detection	NOUN
admet-2603	61	77	,	,	PUNCT
admet-2603	61	78	nm	nm	NOUN
admet-2603	61	79	antipyrine	antipyrine	VERB
admet-2603	61	80	188	188	NUM
admet-2603	61	81	0.56	0.56	NUM
admet-2603	61	82	0.56	0.56	NUM
admet-2603	61	83	9.23	9.23	NUM
admet-2603	61	84	280	280	NUM
admet-2603	61	85	caffeine	caffeine	NOUN
admet-2603	61	86	194	194	NUM
admet-2603	61	87	-0.01	-0.01	NUM
admet-2603	61	88	-0.01	-0.01	NUM
admet-2603	61	89	9.10	9.10	NUM
admet-2603	61	90	290	290	NUM
admet-2603	61	91	furosemide	furosemide	ADV
admet-2603	61	92	331	331	NUM
admet-2603	61	93	2.56	2.56	NUM
admet-2603	61	94	3.53	3.53	NUM
admet-2603	61	95	(	(	PUNCT
admet-2603	61	96	a)b	a)b	X
admet-2603	61	97	-0.41	-0.41	NUM
admet-2603	61	98	7.15	7.15	NUM
admet-2603	61	99	330	330	NUM
admet-2603	61	100	ketoprofen	ketoprofen	NOUN
admet-2603	61	101	254	254	NUM
admet-2603	61	102	3.16	3.16	NUM
admet-2603	61	103	4.00	4.00	NUM
admet-2603	61	104	(	(	PUNCT
admet-2603	61	105	a)b	a)b	PROPN
admet-2603	61	106	0.66	0.66	NUM
admet-2603	61	107	8.05	8.05	NUM
admet-2603	61	108	280	280	NUM
admet-2603	61	109	metoprolol	metoprolol	NOUN
admet-2603	61	110	267	267	NUM
admet-2603	61	111	1.95	1.95	NUM
admet-2603	61	112	9.24	9.24	NUM
admet-2603	61	113	(	(	PUNCT
admet-2603	61	114	b)c	b)c	X
admet-2603	61	115	-0.79	-0.79	NOUN
admet-2603	61	116	7.87	7.87	NUM
admet-2603	61	117	276	276	NUM
admet-2603	61	118	naproxen	naproxen	NOUN
admet-2603	61	119	230	230	NUM
admet-2603	61	120	3.24	3.24	NUM
admet-2603	61	121	4.14	4.14	NUM
admet-2603	61	122	(	(	PUNCT
admet-2603	61	123	a)b	a)b	X
admet-2603	61	124	0.88	0.88	NUM
admet-2603	61	125	8.42	8.42	NUM
admet-2603	61	126	320	320	NUM
admet-2603	61	127	procainamide	procainamide	NOUN
admet-2603	61	128	235	235	NUM
admet-2603	61	129	1.49	1.49	NUM
admet-2603	61	130	9.01	9.01	NUM
admet-2603	61	131	(	(	PUNCT
admet-2603	61	132	b)c	b)c	X
admet-2603	61	133	-1.02	-1.02	NUM
admet-2603	61	134	8.34	8.34	NUM
admet-2603	61	135	310	310	NUM
admet-2603	61	136	propranolol	propranolol	NOUN
admet-2603	61	137	259	259	NUM
admet-2603	61	138	3.48	3.48	NUM
admet-2603	61	139	9.16	9.16	NUM
admet-2603	61	140	(	(	PUNCT
admet-2603	61	141	b)b	b)b	X
admet-2603	61	142	0.82	0.82	NUM
admet-2603	61	143	7.98	7.98	NUM
admet-2603	61	144	320	320	NUM
admet-2603	61	145	a25	a25	NUM
admet-2603	61	146	°	°	PROPN
admet-2603	61	147	c	c	NOUN
admet-2603	62	1	[	[	X
admet-2603	62	2	20	20	NUM
admet-2603	62	3	]	]	PUNCT
admet-2603	62	4	;	;	PUNCT
admet-2603	62	5	b37	b37	PROPN
admet-2603	62	6	°	°	PROPN
admet-2603	62	7	c	c	PROPN
admet-2603	62	8	,	,	PUNCT
admet-2603	62	9	i	i	PRON
admet-2603	62	10	=	=	PROPN
admet-2603	62	11	0.15	0.15	NUM
admet-2603	62	12	m	m	VERB
admet-2603	62	13	;	;	PUNCT
admet-2603	62	14	cconverted	cconverte	VERB
admet-2603	62	15	to	to	ADP
admet-2603	62	16	the	the	DET
admet-2603	62	17	value	value	NOUN
admet-2603	62	18	at	at	ADP
admet-2603	62	19	37	37	NUM
admet-2603	62	20	°	°	SYM
admet-2603	62	21	c	c	NOUN
admet-2603	62	22	from	from	ADP
admet-2603	62	23	the	the	DET
admet-2603	62	24	value	value	NOUN
admet-2603	62	25	measured	measure	VERB
admet-2603	62	26	at	at	ADP
admet-2603	62	27	25	25	NUM
admet-2603	62	28	°	°	NOUN
admet-2603	62	29	c	c	NOUN
admet-2603	62	30	,	,	PUNCT
admet-2603	62	31	i	i	NOUN
admet-2603	62	32	=	=	PROPN
admet-2603	63	1	0.15	0.15	NUM
admet-2603	63	2	m	m	PROPN
admet-2603	64	1	[	[	X
admet-2603	64	2	28	28	NUM
admet-2603	64	3	]	]	PUNCT
admet-2603	64	4	.	.	PUNCT
admet-2603	65	1	doctanol	doctanol	ADJ
admet-2603	65	2	water	water	NOUN
admet-2603	65	3	distribution	distribution	NOUN
admet-2603	65	4	coefficient	coefficient	NOUN
admet-2603	65	5	at	at	ADP
admet-2603	65	6	ph	ph	PROPN
admet-2603	65	7	6.5	6.5	NUM
admet-2603	65	8	.	.	PUNCT
admet-2603	65	9	calculated	calculate	VERB
admet-2603	65	10	from	from	ADP
admet-2603	65	11	log	log	PROPN
admet-2603	65	12	poct	poct	NOUN
admet-2603	65	13	and	and	CCONJ
admet-2603	65	14	pka	pka	PROPN
admet-2603	65	15	.	.	PUNCT
admet-2603	66	1	ediffusion	ediffusion	PROPN
admet-2603	66	2	coefficient	coefficient	NOUN
admet-2603	66	3	of	of	ADP
admet-2603	66	4	monomer	monomer	NOUN
admet-2603	66	5	drug	drug	NOUN
admet-2603	66	6	in	in	ADP
admet-2603	66	7	water	water	NOUN
admet-2603	66	8	at	at	ADP
admet-2603	66	9	37	37	NUM
admet-2603	66	10	°	°	NOUN
admet-2603	66	11	c	c	NOUN
admet-2603	66	12	(	(	PUNCT
admet-2603	66	13	dmono	dmono	NOUN
admet-2603	66	14	=	=	SYM
admet-2603	66	15	9.9×10	9.9×10	NUM
admet-2603	66	16	-	-	SYM
admet-2603	66	17	5	5	NUM
admet-2603	66	18	mw-0.453	mw-0.453	NOUN
admet-2603	66	19	cm2	cm2	NOUN
admet-2603	66	20	s-1)[29	s-1)[29	NOUN
admet-2603	66	21	]	]	X
admet-2603	66	22	experimental	experimental	ADJ
admet-2603	66	23	material	material	NOUN
admet-2603	66	24	the	the	DET
admet-2603	66	25	floating	float	VERB
admet-2603	66	26	lid	lid	NOUN
admet-2603	66	27	for	for	ADP
admet-2603	66	28	μflux	μflux	NOUN
admet-2603	66	29	was	be	AUX
admet-2603	66	30	made	make	VERB
admet-2603	66	31	of	of	ADP
admet-2603	66	32	polystyrene	polystyrene	NOUN
admet-2603	66	33	foam	foam	NOUN
admet-2603	66	34	(	(	PUNCT
admet-2603	66	35	outer	outer	ADJ
admet-2603	66	36	diameter	diameter	NOUN
admet-2603	66	37	:	:	PUNCT
admet-2603	66	38	22.2	22.2	NUM
admet-2603	66	39	mm	mm	NOUN
admet-2603	66	40	,	,	PUNCT
admet-2603	66	41	inner	inner	ADJ
admet-2603	66	42	diameter	diameter	NOUN
admet-2603	66	43	:	:	PUNCT
admet-2603	66	44	7.0	7.0	NUM
admet-2603	66	45	mm	mm	NOUN
admet-2603	66	46	,	,	PUNCT
admet-2603	66	47	thickness	thickness	NOUN
admet-2603	66	48	:	:	PUNCT
admet-2603	66	49	3	3	NUM
admet-2603	66	50	mm	mm	NOUN
admet-2603	66	51	)	)	PUNCT
admet-2603	66	52	.	.	PUNCT
admet-2603	67	1	a	a	DET
admet-2603	67	2	laser	laser	NOUN
admet-2603	67	3	cutter	cutter	NOUN
admet-2603	67	4	was	be	AUX
admet-2603	67	5	used	use	VERB
admet-2603	67	6	to	to	PART
admet-2603	67	7	precisely	precisely	ADV
admet-2603	67	8	cut	cut	VERB
admet-2603	67	9	polystyrene	polystyrene	NOUN
admet-2603	67	10	foam	foam	NOUN
admet-2603	67	11	with	with	ADP
admet-2603	67	12	an	an	DET
admet-2603	67	13	accuracy	accuracy	NOUN
admet-2603	67	14	of	of	ADP
admet-2603	67	15	0.1	0.1	NUM
admet-2603	67	16	mm	mm	NOUN
admet-2603	67	17	.	.	PUNCT
admet-2603	68	1	soybean	soybean	NOUN
admet-2603	68	2	lecithin	lecithin	NOUN
admet-2603	68	3	was	be	AUX
admet-2603	68	4	provided	provide	VERB
admet-2603	68	5	by	by	ADP
admet-2603	68	6	tsuji	tsuji	PROPN
admet-2603	68	7	oil	oil	PROPN
admet-2603	68	8	mills	mills	PROPN
admet-2603	68	9	co.	co.	PROPN
admet-2603	68	10	,	,	PUNCT
admet-2603	68	11	ltd	ltd	PROPN
admet-2603	68	12	(	(	PUNCT
admet-2603	68	13	mie	mie	PROPN
admet-2603	68	14	,	,	PUNCT
admet-2603	68	15	japan	japan	PROPN
admet-2603	68	16	)	)	PUNCT
admet-2603	68	17	(	(	PUNCT
admet-2603	68	18	slp	slp	PROPN
admet-2603	68	19	-	-	PUNCT
admet-2603	68	20	white	white	ADJ
admet-2603	68	21	,	,	PUNCT
admet-2603	68	22	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2603	68	23	(	(	PUNCT
admet-2603	68	24	24	24	NUM
admet-2603	68	25	to	to	PART
admet-2603	68	26	32	32	NUM
admet-2603	68	27	%	%	NOUN
admet-2603	68	28	)	)	PUNCT
admet-2603	68	29	,	,	PUNCT
admet-2603	68	30	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
admet-2603	68	31	(	(	PUNCT
admet-2603	68	32	20	20	NUM
admet-2603	68	33	to	to	PART
admet-2603	68	34	28	28	NUM
admet-2603	68	35	%	%	NOUN
admet-2603	68	36	)	)	PUNCT
admet-2603	68	37	,	,	PUNCT
admet-2603	68	38	phosphatidylinositol	phosphatidylinositol	NOUN
admet-2603	68	39	(	(	PUNCT
admet-2603	68	40	12	12	NUM
admet-2603	68	41	to	to	PART
admet-2603	68	42	20	20	NUM
admet-2603	68	43	%	%	NOUN
admet-2603	68	44	)	)	PUNCT
admet-2603	68	45	,	,	PUNCT
admet-2603	68	46	phosphatidic	phosphatidic	ADJ
admet-2603	68	47	acid	acid	NOUN
admet-2603	68	48	(	(	PUNCT
admet-2603	68	49	8	8	NUM
admet-2603	68	50	to	to	PART
admet-2603	68	51	15	15	NUM
admet-2603	68	52	%	%	NOUN
admet-2603	68	53	)	)	PUNCT
admet-2603	68	54	,	,	PUNCT
admet-2603	68	55	and	and	CCONJ
admet-2603	68	56	lysophosphatidylcholines	lysophosphatidylcholine	NOUN
admet-2603	68	57	(	(	PUNCT
admet-2603	68	58	1	1	NUM
admet-2603	68	59	to	to	PART
admet-2603	68	60	5	5	NUM
admet-2603	68	61	%	%	NOUN
admet-2603	68	62	)	)	PUNCT
admet-2603	68	63	(	(	PUNCT
admet-2603	68	64	based	base	VERB
admet-2603	68	65	on	on	ADP
admet-2603	68	66	the	the	DET
admet-2603	68	67	product	product	NOUN
admet-2603	68	68	information	information	NOUN
admet-2603	68	69	provided	provide	VERB
admet-2603	68	70	by	by	ADP
admet-2603	68	71	the	the	DET
admet-2603	68	72	manufacturer	manufacturer	NOUN
admet-2603	68	73	)	)	PUNCT
admet-2603	68	74	)	)	PUNCT
admet-2603	68	75	.	.	PUNCT
admet-2603	69	1	antipyrine	antipyrine	PROPN
admet-2603	69	2	,	,	PUNCT
admet-2603	69	3	ketoprofen	ketoprofen	VERB
admet-2603	69	4	,	,	PUNCT
admet-2603	69	5	naproxen	naproxen	NOUN
admet-2603	69	6	,	,	PUNCT
admet-2603	69	7	propranolol	propranolol	NOUN
admet-2603	69	8	,	,	PUNCT
admet-2603	69	9	nah2po4∙2h2o	nah2po4∙2h2o	NOUN
admet-2603	69	10	,	,	PUNCT
admet-2603	69	11	nahco3	nahco3	ADJ
admet-2603	69	12	,	,	PUNCT
admet-2603	69	13	nacl	nacl	NOUN
admet-2603	69	14	,	,	PUNCT
admet-2603	69	15	8	8	NUM
admet-2603	69	16	m	m	NOUN
admet-2603	69	17	naoh	naoh	NOUN
admet-2603	69	18	and	and	CCONJ
admet-2603	69	19	6	6	NUM
admet-2603	69	20	m	m	NOUN
admet-2603	69	21	hcl	hcl	PROPN
admet-2603	69	22	were	be	AUX
admet-2603	69	23	purchased	purchase	VERB
admet-2603	69	24	from	from	ADP
admet-2603	69	25	wako	wako	PROPN
admet-2603	69	26	pure	pure	ADJ
admet-2603	69	27	chemical	chemical	NOUN
admet-2603	69	28	industries	industry	NOUN
admet-2603	69	29	,	,	PUNCT
admet-2603	69	30	ltd	ltd	PROPN
admet-2603	69	31	.	.	PROPN
admet-2603	69	32	(	(	PUNCT
admet-2603	69	33	osaka	osaka	PROPN
admet-2603	69	34	,	,	PUNCT
admet-2603	69	35	japan	japan	PROPN
admet-2603	69	36	)	)	PUNCT
admet-2603	69	37	.	.	PUNCT
admet-2603	70	1	caffeine	caffeine	NOUN
admet-2603	70	2	,	,	PUNCT
admet-2603	70	3	furosemide	furosemide	ADV
admet-2603	70	4	,	,	PUNCT
admet-2603	70	5	and	and	CCONJ
admet-2603	70	6	metoprolol	metoprolol	PROPN
admet-2603	70	7	were	be	AUX
admet-2603	70	8	purchased	purchase	VERB
admet-2603	70	9	from	from	ADP
admet-2603	70	10	tokyo	tokyo	PROPN
admet-2603	70	11	chemical	chemical	NOUN
admet-2603	70	12	industry	industry	NOUN
admet-2603	70	13	(	(	PUNCT
admet-2603	70	14	osaka	osaka	PROPN
admet-2603	70	15	,	,	PUNCT
admet-2603	70	16	japan	japan	PROPN
admet-2603	70	17	)	)	PUNCT
admet-2603	70	18	.	.	PUNCT
admet-2603	71	1	procainamide	procainamide	PROPN
admet-2603	71	2	was	be	AUX
admet-2603	71	3	purchased	purchase	VERB
admet-2603	71	4	from	from	ADP
admet-2603	71	5	abcam	abcam	NOUN
admet-2603	71	6	limited	limited	PROPN
admet-2603	71	7	(	(	PUNCT
admet-2603	71	8	cambridge	cambridge	PROPN
admet-2603	71	9	,	,	PUNCT
admet-2603	71	10	ma	ma	PROPN
admet-2603	71	11	,	,	PUNCT
admet-2603	71	12	usa	usa	PROPN
admet-2603	71	13	)	)	PUNCT
admet-2603	71	14	.	.	PUNCT
admet-2603	72	1	methods	method	NOUN
admet-2603	72	2	ph	ph	NOUN
admet-2603	72	3	maintenance	maintenance	NOUN
admet-2603	72	4	in	in	ADP
admet-2603	72	5	μflux	μflux	NOUN
admet-2603	72	6	apparatus	apparatus	NOUN
admet-2603	72	7	with	with	ADP
admet-2603	72	8	floating	float	VERB
admet-2603	72	9	lid	lid	NOUN
admet-2603	72	10	the	the	DET
admet-2603	72	11	membrane	membrane	NOUN
admet-2603	72	12	filter	filter	NOUN
admet-2603	72	13	of	of	ADP
admet-2603	72	14	the	the	DET
admet-2603	72	15	μflux	μflux	NOUN
admet-2603	72	16	apparatus	apparatus	NOUN
admet-2603	72	17	(	(	PUNCT
admet-2603	72	18	pion	pion	PROPN
admet-2603	72	19	inc	inc	PROPN
admet-2603	72	20	.	.	PROPN
admet-2603	72	21	,	,	PUNCT
admet-2603	72	22	billerica	billerica	PROPN
admet-2603	72	23	,	,	PUNCT
admet-2603	72	24	ma	ma	PROPN
admet-2603	72	25	01821	01821	NUM
admet-2603	72	26	,	,	PUNCT
admet-2603	72	27	usa	usa	PROPN
admet-2603	72	28	)	)	PUNCT
admet-2603	72	29	was	be	AUX
admet-2603	72	30	coated	coat	VERB
admet-2603	72	31	with	with	ADP
admet-2603	72	32	25	25	NUM
admet-2603	72	33	μl	μl	ADP
admet-2603	72	34	of	of	ADP
admet-2603	72	35	a	a	DET
admet-2603	72	36	10	10	NUM
admet-2603	72	37	%	%	NOUN
admet-2603	72	38	soybean	soybean	NOUN
admet-2603	72	39	lecithin	lecithin	NOUN
admet-2603	72	40	-	-	PUNCT
admet-2603	72	41	decane	decane	NOUN
admet-2603	72	42	solution	solution	NOUN
admet-2603	72	43	[	[	X
admet-2603	72	44	30	30	NUM
admet-2603	72	45	]	]	PUNCT
admet-2603	72	46	.	.	PUNCT
admet-2603	73	1	a	a	DET
admet-2603	73	2	nahco3	nahco3	ADJ
admet-2603	73	3	solution	solution	NOUN
admet-2603	73	4	(	(	PUNCT
admet-2603	73	5	19.6	19.6	NUM
admet-2603	73	6	ml	ml	NOUN
admet-2603	73	7	,	,	PUNCT
admet-2603	73	8	10.1	10.1	NUM
admet-2603	73	9	mm	mm	NOUN
admet-2603	73	10	,	,	PUNCT
admet-2603	73	11	nacl	nacl	NOUN
admet-2603	73	12	0.13	0.13	NUM
admet-2603	73	13	m	m	NOUN
admet-2603	73	14	)	)	PUNCT
admet-2603	73	15	was	be	AUX
admet-2603	73	16	added	add	VERB
admet-2603	73	17	to	to	ADP
admet-2603	73	18	both	both	CCONJ
admet-2603	73	19	the	the	DET
admet-2603	73	20	donor	donor	NOUN
admet-2603	73	21	and	and	CCONJ
admet-2603	73	22	acceptor	acceptor	NOUN
admet-2603	73	23	chambers	chamber	NOUN
admet-2603	73	24	.	.	PUNCT
admet-2603	74	1	an	an	DET
admet-2603	74	2	hcl	hcl	PROPN
admet-2603	74	3	solution	solution	NOUN
admet-2603	74	4	(	(	PUNCT
admet-2603	74	5	0.4	0.4	NUM
admet-2603	74	6	ml	ml	NOUN
admet-2603	74	7	,	,	PUNCT
admet-2603	74	8	0.17	0.17	NUM
admet-2603	74	9	m	m	VERB
admet-2603	74	10	)	)	PUNCT
admet-2603	74	11	was	be	AUX
admet-2603	74	12	added	add	VERB
admet-2603	74	13	to	to	PART
admet-2603	74	14	adjust	adjust	VERB
admet-2603	74	15	the	the	DET
admet-2603	74	16	ph	ph	ADJ
admet-2603	74	17	value	value	NOUN
admet-2603	74	18	to	to	AUX
admet-2603	74	19	ph	ph	VERB
admet-2603	74	20	6.5	6.5	NUM
admet-2603	74	21	(	(	PUNCT
admet-2603	74	22	final	final	ADJ
admet-2603	74	23	conditions	condition	NOUN
admet-2603	74	24	:	:	PUNCT
admet-2603	74	25	bcb	bcb	PROPN
admet-2603	74	26	=	=	SYM
admet-2603	74	27	10	10	NUM
admet-2603	74	28	mm	mm	NOUN
admet-2603	74	29	,	,	PUNCT
admet-2603	74	30			NOUN
admet-2603	74	31	=	=	NOUN
admet-2603	74	32	4.4	4.4	NUM
admet-2603	74	33	mm	mm	NUM
admet-2603	74	34	ph-1	ph-1	PROPN
admet-2603	74	35	,	,	PUNCT
admet-2603	74	36	i	i	PRON
admet-2603	74	37	=	=	PROPN
admet-2603	74	38	0.14	0.14	NUM
admet-2603	74	39	m	m	PROPN
admet-2603	74	40	)	)	PUNCT
admet-2603	74	41	.	.	PUNCT
admet-2603	75	1	the	the	DET
admet-2603	75	2			PROPN
admet-2603	75	3	value	value	NOUN
admet-2603	75	4	was	be	AUX
admet-2603	75	5	calculated	calculate	VERB
admet-2603	75	6	by	by	ADP
admet-2603	75	7	the	the	DET
admet-2603	75	8	van	van	PROPN
admet-2603	75	9	slyke	slyke	PROPN
admet-2603	75	10	equation	equation	NOUN
admet-2603	75	11	[	[	X
admet-2603	75	12	31	31	NUM
admet-2603	75	13	]	]	PUNCT
admet-2603	75	14	using	use	VERB
admet-2603	75	15	the	the	DET
admet-2603	75	16	second	second	ADJ
admet-2603	75	17	pka	pka	PROPN
admet-2603	75	18	values	value	NOUN
admet-2603	75	19	of	of	ADP
admet-2603	75	20	buffer	buffer	NOUN
admet-2603	75	21	species	specie	NOUN
admet-2603	75	22	,	,	PUNCT
admet-2603	75	23	assuming	assume	VERB
admet-2603	75	24	the	the	DET
admet-2603	75	25	activity	activity	NOUN
admet-2603	75	26	coefficient	coefficient	NOUN
admet-2603	75	27	is	be	AUX
admet-2603	75	28	1	1	NUM
admet-2603	75	29	.	.	PUNCT
admet-2603	76	1	the	the	DET
admet-2603	76	2	temperature	temperature	NOUN
admet-2603	76	3	was	be	AUX
admet-2603	76	4	maintained	maintain	VERB
admet-2603	76	5	at	at	ADP
admet-2603	76	6	37	37	NUM
admet-2603	76	7	°	°	NOUN
admet-2603	76	8	c	c	NOUN
admet-2603	76	9	.	.	PUNCT
admet-2603	77	1	the	the	DET
admet-2603	77	2	paddle	paddle	NOUN
admet-2603	77	3	rotation	rotation	NOUN
admet-2603	77	4	speed	speed	NOUN
admet-2603	77	5	was	be	AUX
admet-2603	77	6	set	set	VERB
admet-2603	77	7	to	to	ADP
admet-2603	77	8	150	150	NUM
admet-2603	77	9	rpm	rpm	NOUN
admet-2603	77	10	.	.	PUNCT
admet-2603	78	1	the	the	DET
admet-2603	78	2	solution	solution	NOUN
admet-2603	78	3	surface	surface	NOUN
admet-2603	78	4	was	be	AUX
admet-2603	78	5	covered	cover	VERB
admet-2603	78	6	by	by	ADP
admet-2603	78	7	a	a	DET
admet-2603	78	8	floating	float	VERB
admet-2603	78	9	lid	lid	NOUN
admet-2603	78	10	(	(	PUNCT
admet-2603	78	11	figure	figure	NOUN
admet-2603	78	12	1	1	NUM
admet-2603	78	13	)	)	PUNCT
admet-2603	78	14	.	.	PUNCT
admet-2603	79	1	the	the	DET
admet-2603	79	2	bulk	bulk	ADJ
admet-2603	79	3	phase	phase	NOUN
admet-2603	79	4	ph	ph	NOUN
admet-2603	79	5	value	value	NOUN
admet-2603	79	6	was	be	AUX
admet-2603	79	7	measured	measure	VERB
admet-2603	79	8	at	at	ADP
admet-2603	79	9	each	each	DET
admet-2603	79	10	time	time	NOUN
admet-2603	79	11	point	point	NOUN
admet-2603	79	12	using	use	VERB
admet-2603	79	13	a	a	DET
admet-2603	79	14	gel	gel	NOUN
admet-2603	79	15	-	-	PUNCT
admet-2603	79	16	filled	fill	VERB
admet-2603	79	17	ph	ph	ADJ
admet-2603	79	18	sensor	sensor	NOUN
admet-2603	79	19	cartridge	cartridge	VERB
admet-2603	79	20	300	300	NUM
admet-2603	79	21	-	-	PUNCT
admet-2603	79	22	p	p	NOUN
admet-2603	79	23	-	-	PUNCT
admet-2603	79	24	c	c	NOUN
admet-2603	79	25	(	(	PUNCT
admet-2603	79	26	horiba	horiba	PROPN
admet-2603	79	27	advanced	advanced	ADJ
admet-2603	79	28	techno	techno	NOUN
admet-2603	79	29	,	,	PUNCT
admet-2603	79	30	co.	co.	PROPN
admet-2603	79	31	,	,	PUNCT
admet-2603	79	32	ltd	ltd	PROPN
admet-2603	79	33	.	.	PROPN
admet-2603	79	34	,	,	PUNCT
admet-2603	79	35	kyoto	kyoto	PROPN
admet-2603	79	36	,	,	PUNCT
admet-2603	79	37	japan	japan	PROPN
admet-2603	79	38	)	)	PUNCT
admet-2603	79	39	.	.	PUNCT
admet-2603	80	1	the	the	DET
admet-2603	80	2	ph	ph	PROPN
admet-2603	80	3	maintenance	maintenance	NOUN
admet-2603	80	4	test	test	NOUN
admet-2603	80	5	was	be	AUX
admet-2603	80	6	performed	perform	VERB
admet-2603	80	7	in	in	ADP
admet-2603	80	8	triplicate	triplicate	PROPN
admet-2603	80	9	.	.	PUNCT
admet-2603	81	1	flux	flux	PROPN
admet-2603	81	2	measurement	measurement	PROPN
admet-2603	81	3	the	the	DET
admet-2603	81	4	flux	flux	PROPN
admet-2603	81	5	measurement	measurement	NOUN
admet-2603	81	6	was	be	AUX
admet-2603	81	7	performed	perform	VERB
admet-2603	81	8	in	in	ADP
admet-2603	81	9	an	an	DET
admet-2603	81	10	iso	iso	NOUN
admet-2603	81	11	-	-	PUNCT
admet-2603	81	12	ph	ph	ADJ
admet-2603	81	13	condition	condition	NOUN
admet-2603	81	14	(	(	PUNCT
admet-2603	81	15	ph	ph	X
admet-2603	81	16	6.5	6.5	NUM
admet-2603	81	17	for	for	ADP
admet-2603	81	18	both	both	PRON
admet-2603	81	19	donor	donor	NOUN
admet-2603	81	20	and	and	CCONJ
admet-2603	81	21	acceptor	acceptor	NOUN
admet-2603	81	22	solutions	solution	NOUN
admet-2603	81	23	)	)	PUNCT
admet-2603	81	24	.	.	PUNCT
admet-2603	82	1	the	the	DET
admet-2603	82	2	lipid	lipid	NOUN
admet-2603	82	3	membrane	membrane	NOUN
admet-2603	82	4	was	be	AUX
admet-2603	82	5	prepared	prepare	VERB
admet-2603	82	6	as	as	SCONJ
admet-2603	82	7	described	describe	VERB
admet-2603	82	8	above	above	ADV
admet-2603	82	9	.	.	PUNCT
admet-2603	83	1	a	a	DET
admet-2603	83	2	nahco3	nahco3	ADJ
admet-2603	83	3	solution	solution	NOUN
admet-2603	83	4	(	(	PUNCT
admet-2603	83	5	98	98	NUM
admet-2603	83	6	ml	ml	NOUN
admet-2603	83	7	,	,	PUNCT
admet-2603	83	8	10.1	10.1	NUM
admet-2603	83	9	mm	mm	NOUN
admet-2603	83	10	,	,	PUNCT
admet-2603	83	11	nacl	nacl	NOUN
admet-2603	83	12	0.13	0.13	NUM
admet-2603	83	13	m	m	NOUN
admet-2603	83	14	)	)	PUNCT
admet-2603	83	15	was	be	AUX
admet-2603	83	16	added	add	VERB
admet-2603	83	17	to	to	ADP
admet-2603	83	18	a	a	DET
admet-2603	83	19	100	100	NUM
admet-2603	83	20	ml	ml	NOUN
admet-2603	83	21	beaker	beaker	NOUN
admet-2603	83	22	.	.	PUNCT
admet-2603	84	1	an	an	DET
admet-2603	84	2	hcl	hcl	PROPN
admet-2603	84	3	solution	solution	NOUN
admet-2603	84	4	(	(	PUNCT
admet-2603	84	5	2	2	NUM
admet-2603	84	6	ml	ml	NOUN
admet-2603	84	7	,	,	PUNCT
admet-2603	84	8	0.17	0.17	NUM
admet-2603	84	9	m	m	VERB
admet-2603	84	10	)	)	PUNCT
admet-2603	84	11	was	be	AUX
admet-2603	84	12	added	add	VERB
admet-2603	84	13	to	to	PART
admet-2603	84	14	adjust	adjust	VERB
admet-2603	84	15	the	the	DET
admet-2603	84	16	ph	ph	ADJ
admet-2603	84	17	value	value	NOUN
admet-2603	84	18	to	to	AUX
admet-2603	84	19	ph	ph	VERB
admet-2603	84	20	6.5	6.5	NUM
admet-2603	84	21	(	(	PUNCT
admet-2603	84	22	final	final	ADJ
admet-2603	84	23	conditions	condition	NOUN
admet-2603	84	24	:	:	PUNCT
admet-2603	84	25	bcb	bcb	PROPN
admet-2603	84	26	=	=	SYM
admet-2603	84	27	10	10	NUM
admet-2603	84	28	mm	mm	NOUN
admet-2603	84	29	(	(	PUNCT
admet-2603	85	1			NOUN
admet-2603	85	2	=	=	SYM
admet-2603	85	3	4.4	4.4	NUM
admet-2603	85	4	mm	mm	NUM
admet-2603	85	5	ph-1	ph-1	PROPN
admet-2603	85	6	)	)	PUNCT
admet-2603	85	7	,	,	PUNCT
admet-2603	85	8	i	i	PRON
admet-2603	85	9	=	=	PROPN
admet-2603	85	10	0.14	0.14	NUM
admet-2603	85	11	m	m	PROPN
admet-2603	85	12	)	)	PUNCT
admet-2603	85	13	.	.	PUNCT
admet-2603	86	1	each	each	DET
admet-2603	86	2	drug	drug	NOUN
admet-2603	86	3	was	be	AUX
admet-2603	86	4	dissolved	dissolve	VERB
admet-2603	86	5	,	,	PUNCT
admet-2603	86	6	and	and	CCONJ
admet-2603	86	7	ph	ph	NOUN
admet-2603	86	8	was	be	AUX
admet-2603	86	9	re	re	VERB
admet-2603	86	10	-	-	VERB
admet-2603	86	11	adjusted	adjust	VERB
admet-2603	86	12	to	to	ADP
admet-2603	86	13	ph	ph	PROPN
admet-2603	86	14	6.5	6.5	NUM
admet-2603	86	15	by	by	ADP
admet-2603	86	16	adding	add	VERB
admet-2603	86	17	a	a	DET
admet-2603	86	18	small	small	ADJ
admet-2603	86	19	amount	amount	NOUN
admet-2603	86	20	of	of	ADP
admet-2603	86	21	1	1	NUM
admet-2603	86	22	m	m	NOUN
admet-2603	86	23	naoh	naoh	NOUN
admet-2603	86	24	or	or	CCONJ
admet-2603	86	25	1	1	NUM
admet-2603	86	26	m	m	NOUN
admet-2603	86	27	hcl	hcl	PROPN
admet-2603	86	28	.	.	PUNCT
admet-2603	87	1	the	the	DET
admet-2603	87	2	initial	initial	ADJ
admet-2603	87	3	concentration	concentration	NOUN
admet-2603	87	4	of	of	ADP
admet-2603	87	5	each	each	DET
admet-2603	87	6	drug	drug	NOUN
admet-2603	87	7	in	in	ADP
admet-2603	87	8	the	the	DET
admet-2603	87	9	donor	donor	NOUN
admet-2603	87	10	solution	solution	NOUN
admet-2603	87	11	(	(	PUNCT
admet-2603	87	12	cd	cd	PROPN
admet-2603	87	13	,	,	PUNCT
admet-2603	87	14	init	init	VERB
admet-2603	87	15	)	)	PUNCT
admet-2603	87	16	was	be	AUX
admet-2603	87	17	set	set	VERB
admet-2603	87	18	so	so	SCONJ
admet-2603	87	19	that	that	SCONJ
admet-2603	87	20	the	the	DET
admet-2603	87	21	drug	drug	NOUN
admet-2603	87	22	concentration	concentration	NOUN
admet-2603	87	23	in	in	ADP
admet-2603	87	24	the	the	DET
admet-2603	87	25	acceptor	acceptor	NOUN
admet-2603	87	26	solution	solution	NOUN
admet-2603	87	27	could	could	AUX
admet-2603	87	28	be	be	AUX
admet-2603	87	29	detected	detect	VERB
admet-2603	87	30	(	(	PUNCT
admet-2603	87	31	table	table	NOUN
admet-2603	87	32	2	2	NUM
admet-2603	87	33	)	)	PUNCT
admet-2603	87	34	.	.	PUNCT
admet-2603	88	1	it	it	PRON
admet-2603	88	2	was	be	AUX
admet-2603	88	3	visually	visually	ADV
admet-2603	88	4	confirmed	confirm	VERB
admet-2603	88	5	that	that	SCONJ
admet-2603	88	6	the	the	DET
admet-2603	88	7	added	add	VERB
admet-2603	88	8	drug	drug	NOUN
admet-2603	88	9	was	be	AUX
admet-2603	88	10	completely	completely	ADV
admet-2603	88	11	dissolved	dissolve	VERB
admet-2603	88	12	.	.	PUNCT
admet-2603	89	1	a	a	DET
admet-2603	89	2	floating	float	VERB
admet-2603	89	3	lid	lid	NOUN
admet-2603	89	4	for	for	ADP
admet-2603	89	5	the	the	DET
admet-2603	89	6	100	100	NUM
admet-2603	89	7	ml	ml	NOUN
admet-2603	89	8	beaker	beaker	NOUN
admet-2603	89	9	was	be	AUX
admet-2603	89	10	used	use	VERB
admet-2603	89	11	during	during	ADP
admet-2603	89	12	the	the	DET
admet-2603	89	13	above	above	ADJ
admet-2603	89	14	procedures	procedure	NOUN
admet-2603	89	15	(	(	PUNCT
admet-2603	89	16	covering	cover	VERB
admet-2603	89	17	>	>	SYM
admet-2603	89	18	95	95	NUM
admet-2603	89	19	%	%	NOUN
admet-2603	89	20	of	of	ADP
admet-2603	89	21	the	the	DET
admet-2603	89	22	air	air	NOUN
admet-2603	89	23	-	-	PUNCT
admet-2603	89	24	solution	solution	NOUN
admet-2603	89	25	interface	interface	NOUN
admet-2603	89	26	)	)	PUNCT
admet-2603	89	27	.	.	PUNCT
admet-2603	90	1	the	the	DET
admet-2603	90	2	drug	drug	NOUN
admet-2603	90	3	solution	solution	NOUN
admet-2603	90	4	(	(	PUNCT
admet-2603	90	5	20	20	NUM
admet-2603	90	6	ml	ml	NOUN
admet-2603	90	7	)	)	PUNCT
admet-2603	90	8	was	be	AUX
admet-2603	90	9	added	add	VERB
admet-2603	90	10	to	to	ADP
admet-2603	90	11	the	the	DET
admet-2603	90	12	donor	donor	NOUN
admet-2603	90	13	chamber	chamber	PROPN
admet-2603	90	14	and	and	CCONJ
admet-2603	90	15	the	the	DET
admet-2603	90	16	blank	blank	ADJ
admet-2603	90	17	solution	solution	NOUN
admet-2603	90	18	(	(	PUNCT
admet-2603	90	19	20	20	NUM
admet-2603	90	20	ml	ml	NOUN
admet-2603	90	21	)	)	PUNCT
admet-2603	90	22	was	be	AUX
admet-2603	90	23	added	add	VERB
admet-2603	90	24	to	to	ADP
admet-2603	90	25	the	the	DET
admet-2603	90	26	acceptor	acceptor	NOUN
admet-2603	90	27	chamber	chamber	NOUN
admet-2603	90	28	.	.	PUNCT
admet-2603	91	1	the	the	DET
admet-2603	91	2	solution	solution	NOUN
admet-2603	91	3	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	VERB
admet-2603	91	4	s.	s.	PROPN
admet-2603	91	5	ishida	ishida	PROPN
admet-2603	91	6	et	et	PROPN
admet-2603	91	7	al	al	PROPN
admet-2603	91	8	.	.	PROPN
admet-2603	91	9	admet	admet	PROPN
admet-2603	91	10	&	&	CCONJ
admet-2603	91	11	dmpk	dmpk	PROPN
admet-2603	91	12	13(1	13(1	NUM
admet-2603	91	13	)	)	PUNCT
admet-2603	91	14	(	(	PUNCT
admet-2603	91	15	2025	2025	NUM
admet-2603	91	16	)	)	PUNCT
admet-2603	91	17	2603	2603	NUM
admet-2603	91	18	4	4	NUM
admet-2603	91	19	surface	surface	NOUN
admet-2603	91	20	was	be	AUX
admet-2603	91	21	covered	cover	VERB
admet-2603	91	22	by	by	ADP
admet-2603	91	23	a	a	DET
admet-2603	91	24	floating	float	VERB
admet-2603	91	25	lid	lid	NOUN
admet-2603	91	26	for	for	ADP
admet-2603	91	27	μflux	μflux	NOUN
admet-2603	91	28	.	.	PUNCT
admet-2603	92	1	ppb	ppb	NOUN
admet-2603	92	2	was	be	AUX
admet-2603	92	3	used	use	VERB
admet-2603	92	4	for	for	ADP
admet-2603	92	5	comparison	comparison	NOUN
admet-2603	92	6	(	(	PUNCT
admet-2603	92	7	ph	ph	NOUN
admet-2603	92	8	6.5	6.5	NUM
admet-2603	92	9	,	,	PUNCT
admet-2603	92	10	ppb	ppb	NOUN
admet-2603	92	11	=	=	SYM
admet-2603	92	12	8	8	NUM
admet-2603	92	13	mm	mm	NOUN
admet-2603	92	14	(	(	PUNCT
admet-2603	92	15			NOUN
admet-2603	92	16	=	=	SYM
admet-2603	92	17	4.4	4.4	NUM
admet-2603	92	18	mm	mm	NUM
admet-2603	92	19	ph-1	ph-1	PROPN
admet-2603	92	20	)	)	PUNCT
admet-2603	92	21	,	,	PUNCT
admet-2603	92	22	i	i	PRON
admet-2603	92	23	=	=	PROPN
admet-2603	92	24	0.14	0.14	NUM
admet-2603	92	25	m	m	PROPN
admet-2603	92	26	)	)	PUNCT
admet-2603	92	27	.	.	PUNCT
admet-2603	93	1	the	the	DET
admet-2603	93	2	temperature	temperature	NOUN
admet-2603	93	3	was	be	AUX
admet-2603	93	4	maintained	maintain	VERB
admet-2603	93	5	at	at	ADP
admet-2603	93	6	37	37	NUM
admet-2603	93	7	°	°	NOUN
admet-2603	93	8	c	c	NOUN
admet-2603	93	9	.	.	PUNCT
admet-2603	94	1	the	the	DET
admet-2603	94	2	paddle	paddle	NOUN
admet-2603	94	3	rotation	rotation	NOUN
admet-2603	94	4	speed	speed	NOUN
admet-2603	94	5	was	be	AUX
admet-2603	94	6	set	set	VERB
admet-2603	94	7	to	to	ADP
admet-2603	94	8	150	150	NUM
admet-2603	94	9	rpm	rpm	NOUN
admet-2603	94	10	.	.	PUNCT
admet-2603	95	1	the	the	DET
admet-2603	95	2	drug	drug	NOUN
admet-2603	95	3	concentrations	concentration	NOUN
admet-2603	95	4	in	in	ADP
admet-2603	95	5	the	the	DET
admet-2603	95	6	donor	donor	NOUN
admet-2603	95	7	and	and	CCONJ
admet-2603	95	8	acceptor	acceptor	NOUN
admet-2603	95	9	solutions	solution	NOUN
admet-2603	95	10	were	be	AUX
admet-2603	95	11	determined	determine	VERB
admet-2603	95	12	by	by	ADP
admet-2603	95	13	a	a	DET
admet-2603	95	14	uv	uv	NOUN
admet-2603	95	15	probe	probe	NOUN
admet-2603	95	16	(	(	PUNCT
admet-2603	95	17	2	2	NUM
admet-2603	95	18	and	and	CCONJ
admet-2603	95	19	20	20	NUM
admet-2603	95	20	mm	mm	NOUN
admet-2603	95	21	apertures	aperture	NOUN
admet-2603	95	22	,	,	PUNCT
admet-2603	95	23	respectively	respectively	ADV
admet-2603	95	24	)	)	PUNCT
admet-2603	95	25	(	(	PUNCT
admet-2603	95	26	table	table	NOUN
admet-2603	95	27	1	1	NUM
admet-2603	95	28	)	)	PUNCT
admet-2603	95	29	.	.	PUNCT
admet-2603	96	1	the	the	DET
admet-2603	96	2	initial	initial	ADJ
admet-2603	96	3	and	and	CCONJ
admet-2603	96	4	final	final	ADJ
admet-2603	96	5	bulk	bulk	ADJ
admet-2603	96	6	phase	phase	NOUN
admet-2603	96	7	ph	ph	ADJ
admet-2603	96	8	values	value	NOUN
admet-2603	96	9	were	be	AUX
admet-2603	96	10	measured	measure	VERB
admet-2603	96	11	as	as	ADP
admet-2603	96	12	described	describe	VERB
admet-2603	96	13	above	above	ADV
admet-2603	96	14	.	.	PUNCT
admet-2603	97	1	the	the	DET
admet-2603	97	2	flux	flux	NOUN
admet-2603	97	3	value	value	NOUN
admet-2603	97	4	(	(	PUNCT
admet-2603	97	5	j	j	NOUN
admet-2603	97	6	)	)	PUNCT
admet-2603	97	7	was	be	AUX
admet-2603	97	8	calculated	calculate	VERB
admet-2603	97	9	from	from	ADP
admet-2603	97	10	the	the	DET
admet-2603	97	11	slope	slope	NOUN
admet-2603	97	12	of	of	ADP
admet-2603	97	13	the	the	DET
admet-2603	97	14	drug	drug	NOUN
admet-2603	97	15	concentration	concentration	NOUN
admet-2603	97	16	-	-	PUNCT
admet-2603	97	17	time	time	NOUN
admet-2603	97	18	curve	curve	NOUN
admet-2603	97	19	in	in	ADP
admet-2603	97	20	the	the	DET
admet-2603	97	21	acceptor	acceptor	NOUN
admet-2603	97	22	solution	solution	NOUN
admet-2603	97	23	from	from	ADP
admet-2603	97	24	30	30	NUM
admet-2603	97	25	to	to	PART
admet-2603	97	26	120	120	NUM
admet-2603	97	27	min	min	NOUN
admet-2603	97	28	.	.	PUNCT
admet-2603	98	1	the	the	DET
admet-2603	98	2	effective	effective	ADJ
admet-2603	98	3	permeability	permeability	NOUN
admet-2603	98	4	(	(	PUNCT
admet-2603	98	5	pe	pe	NOUN
admet-2603	98	6	)	)	PUNCT
admet-2603	98	7	value	value	NOUN
admet-2603	98	8	was	be	AUX
admet-2603	98	9	calculated	calculate	VERB
admet-2603	98	10	from	from	ADP
admet-2603	98	11	the	the	DET
admet-2603	98	12	flux	flux	NOUN
admet-2603	98	13	value	value	NOUN
admet-2603	98	14	and	and	CCONJ
admet-2603	98	15	the	the	DET
admet-2603	98	16	final	final	ADJ
admet-2603	98	17	donor	donor	NOUN
admet-2603	98	18	concentration	concentration	NOUN
admet-2603	98	19	(	(	PUNCT
admet-2603	98	20	cd	cd	NOUN
admet-2603	98	21	,	,	PUNCT
admet-2603	98	22	final	final	ADJ
admet-2603	98	23	)	)	PUNCT
admet-2603	98	24	as	as	ADP
admet-2603	98	25	pe	pe	PROPN
admet-2603	98	26	=	=	SYM
admet-2603	98	27	j	j	PROPN
admet-2603	98	28	/	/	SYM
admet-2603	98	29	cd	cd	PROPN
admet-2603	98	30	,	,	PUNCT
admet-2603	98	31	final	final	ADJ
admet-2603	98	32	.	.	PUNCT
admet-2603	99	1	the	the	DET
admet-2603	99	2	flux	flux	PROPN
admet-2603	99	3	measurement	measurement	NOUN
admet-2603	99	4	was	be	AUX
admet-2603	99	5	performed	perform	VERB
admet-2603	99	6	in	in	ADP
admet-2603	99	7	triplicate	triplicate	NOUN
admet-2603	99	8	.	.	PUNCT
admet-2603	100	1	results	result	NOUN
admet-2603	100	2	and	and	CCONJ
admet-2603	100	3	discussion	discussion	NOUN
admet-2603	100	4	first	first	ADV
admet-2603	100	5	,	,	PUNCT
admet-2603	100	6	the	the	DET
admet-2603	100	7	ph	ph	ADJ
admet-2603	100	8	maintenance	maintenance	NOUN
admet-2603	100	9	performance	performance	NOUN
admet-2603	100	10	of	of	ADP
admet-2603	100	11	the	the	DET
admet-2603	100	12	floating	float	VERB
admet-2603	100	13	lid	lid	NOUN
admet-2603	100	14	was	be	AUX
admet-2603	100	15	evaluated	evaluate	VERB
admet-2603	100	16	for	for	ADP
admet-2603	100	17	μflux	μflux	NOUN
admet-2603	100	18	(	(	PUNCT
admet-2603	100	19	figure	figure	NOUN
admet-2603	100	20	1	1	NUM
admet-2603	100	21	)	)	PUNCT
admet-2603	100	22	.	.	PUNCT
admet-2603	101	1	without	without	ADP
admet-2603	101	2	the	the	DET
admet-2603	101	3	floating	float	VERB
admet-2603	101	4	lid	lid	NOUN
admet-2603	101	5	,	,	PUNCT
admet-2603	101	6	the	the	DET
admet-2603	101	7	ph	ph	ADJ
admet-2603	101	8	value	value	NOUN
admet-2603	101	9	of	of	ADP
admet-2603	101	10	bcb	bcb	PROPN
admet-2603	101	11	was	be	AUX
admet-2603	101	12	rapidly	rapidly	ADV
admet-2603	101	13	increased	increase	VERB
admet-2603	101	14	by	by	ADP
admet-2603	101	15	the	the	DET
admet-2603	101	16	loss	loss	NOUN
admet-2603	101	17	of	of	ADP
admet-2603	101	18	co2	co2	NOUN
admet-2603	101	19	(	(	PUNCT
admet-2603	101	20	figure	figure	NOUN
admet-2603	101	21	2	2	NUM
admet-2603	101	22	)	)	PUNCT
admet-2603	101	23	.	.	PUNCT
admet-2603	102	1	the	the	DET
admet-2603	102	2	floating	float	VERB
admet-2603	102	3	lid	lid	NOUN
admet-2603	102	4	suppressed	suppress	VERB
admet-2603	102	5	the	the	DET
admet-2603	102	6	ph	ph	ADJ
admet-2603	102	7	increase	increase	NOUN
admet-2603	102	8	completely	completely	ADV
admet-2603	102	9	until	until	ADP
admet-2603	102	10	60	60	NUM
admet-2603	102	11	min	min	NOUN
admet-2603	102	12	and	and	CCONJ
admet-2603	102	13	to	to	ADP
admet-2603	102	14	less	less	ADJ
admet-2603	102	15	than	than	ADP
admet-2603	102	16	0.1	0.1	NUM
admet-2603	102	17	for	for	ADP
admet-2603	102	18	120	120	NUM
admet-2603	102	19	min	min	NOUN
admet-2603	102	20	.	.	PROPN
admet-2603	103	1	as	as	SCONJ
admet-2603	103	2	the	the	DET
admet-2603	103	3	surface	surface	NOUN
admet-2603	103	4	-	-	PUNCT
admet-2603	103	5	to	to	ADP
admet-2603	103	6	-	-	PUNCT
admet-2603	103	7	volume	volume	NOUN
admet-2603	103	8	ratio	ratio	NOUN
admet-2603	103	9	becomes	become	VERB
admet-2603	103	10	smaller	small	ADJ
admet-2603	103	11	,	,	PUNCT
admet-2603	103	12	such	such	ADJ
admet-2603	103	13	as	as	ADP
admet-2603	103	14	in	in	ADP
admet-2603	103	15	the	the	DET
admet-2603	103	16	case	case	NOUN
admet-2603	103	17	of	of	ADP
admet-2603	103	18	μflux	μflux	NOUN
admet-2603	103	19	,	,	PUNCT
admet-2603	103	20	it	it	PRON
admet-2603	103	21	becomes	become	VERB
admet-2603	103	22	more	more	ADV
admet-2603	103	23	challenging	challenging	ADJ
admet-2603	103	24	to	to	PART
admet-2603	103	25	maintain	maintain	VERB
admet-2603	103	26	the	the	DET
admet-2603	103	27	ph	ph	ADJ
admet-2603	103	28	value	value	NOUN
admet-2603	103	29	by	by	ADP
admet-2603	103	30	a	a	DET
admet-2603	103	31	floating	float	VERB
admet-2603	103	32	lid	lid	NOUN
admet-2603	103	33	.	.	PUNCT
admet-2603	104	1	in	in	ADP
admet-2603	104	2	this	this	DET
admet-2603	104	3	study	study	NOUN
admet-2603	104	4	,	,	PUNCT
admet-2603	104	5	a	a	DET
admet-2603	104	6	precise	precise	ADJ
admet-2603	104	7	laser	laser	NOUN
admet-2603	104	8	cutter	cutter	NOUN
admet-2603	104	9	was	be	AUX
admet-2603	104	10	used	use	VERB
admet-2603	104	11	to	to	PART
admet-2603	104	12	produce	produce	VERB
admet-2603	104	13	the	the	DET
admet-2603	104	14	floating	float	VERB
admet-2603	104	15	lid	lid	NOUN
admet-2603	104	16	for	for	ADP
admet-2603	104	17	μflux	μflux	NOUN
admet-2603	104	18	.	.	PUNCT
admet-2603	105	1	the	the	DET
admet-2603	105	2	ph	ph	ADJ
admet-2603	105	3	value	value	NOUN
admet-2603	105	4	was	be	AUX
admet-2603	105	5	well	well	ADV
admet-2603	105	6	maintained	maintain	VERB
admet-2603	105	7	by	by	ADP
admet-2603	105	8	the	the	DET
admet-2603	105	9	floating	float	VERB
admet-2603	105	10	lid	lid	NOUN
admet-2603	105	11	method	method	NOUN
admet-2603	105	12	,	,	PUNCT
admet-2603	105	13	suggesting	suggest	VERB
admet-2603	105	14	that	that	SCONJ
admet-2603	105	15	this	this	DET
admet-2603	105	16	method	method	NOUN
admet-2603	105	17	can	can	AUX
admet-2603	105	18	be	be	AUX
admet-2603	105	19	used	use	VERB
admet-2603	105	20	for	for	ADP
admet-2603	105	21	further	further	ADJ
admet-2603	105	22	flux	flux	NOUN
admet-2603	105	23	measurements	measurement	NOUN
admet-2603	105	24	.	.	PUNCT
admet-2603	106	1	time	time	NOUN
admet-2603	106	2	,	,	PUNCT
admet-2603	106	3	min	min	NOUN
admet-2603	106	4	figure	figure	NOUN
admet-2603	106	5	2	2	NUM
admet-2603	106	6	ph	ph	NOUN
admet-2603	106	7	change	change	NOUN
admet-2603	106	8	of	of	ADP
admet-2603	106	9	donor	donor	NOUN
admet-2603	106	10	solution	solution	NOUN
admet-2603	106	11	with	with	ADP
admet-2603	106	12	or	or	CCONJ
admet-2603	106	13	without	without	ADP
admet-2603	106	14	floating	float	VERB
admet-2603	106	15	lid	lid	NOUN
admet-2603	106	16	.	.	PUNCT
admet-2603	107	1	mean	mean	NOUN
admet-2603	107	2	±	±	NUM
admet-2603	107	3	s.d	s.d	PROPN
admet-2603	107	4	.	.	PROPN
admet-2603	107	5	,	,	PUNCT
admet-2603	107	6	n	n	PROPN
admet-2603	107	7	=	=	SYM
admet-2603	107	8	3	3	X
admet-2603	107	9	.	.	PUNCT
admet-2603	108	1	in	in	ADP
admet-2603	108	2	the	the	DET
admet-2603	108	3	flux	flux	NOUN
admet-2603	108	4	measurements	measurement	NOUN
admet-2603	108	5	,	,	PUNCT
admet-2603	108	6	the	the	DET
admet-2603	108	7	initial	initial	ADJ
admet-2603	108	8	values	value	NOUN
admet-2603	108	9	of	of	ADP
admet-2603	108	10	phbulk	phbulk	ADJ
admet-2603	108	11	were	be	AUX
admet-2603	108	12	6.5	6.5	NUM
admet-2603	108	13	±	±	NUM
admet-2603	108	14	0.0	0.0	NUM
admet-2603	108	15	and	and	CCONJ
admet-2603	108	16	the	the	DET
admet-2603	108	17	final	final	ADJ
admet-2603	108	18	values	value	NOUN
admet-2603	108	19	of	of	ADP
admet-2603	108	20	phbulk	phbulk	NOUN
admet-2603	108	21	at	at	ADP
admet-2603	108	22	120	120	NUM
admet-2603	108	23	min	min	NOUN
admet-2603	108	24	were	be	AUX
admet-2603	108	25	6.5	6.5	NUM
admet-2603	108	26	±	±	NUM
admet-2603	108	27	0.1	0.1	NUM
admet-2603	108	28	in	in	ADP
admet-2603	108	29	all	all	DET
admet-2603	108	30	cases	case	NOUN
admet-2603	108	31	(	(	PUNCT
admet-2603	108	32	table	table	NOUN
admet-2603	108	33	2	2	NUM
admet-2603	108	34	)	)	PUNCT
admet-2603	108	35	.	.	PUNCT
admet-2603	109	1	the	the	DET
admet-2603	109	2	pe	pe	PROPN
admet-2603	109	3	values	value	NOUN
admet-2603	109	4	of	of	ADP
admet-2603	109	5	lipophilic	lipophilic	ADJ
admet-2603	109	6	weakly	weakly	ADJ
admet-2603	109	7	acidic	acidic	ADJ
admet-2603	109	8	drugs	drug	NOUN
admet-2603	109	9	(	(	PUNCT
admet-2603	109	10	ketoprofen	ketoprofen	VERB
admet-2603	109	11	and	and	CCONJ
admet-2603	109	12	naproxen	naproxen	PROPN
admet-2603	109	13	,	,	PUNCT
admet-2603	109	14	log	log	PROPN
admet-2603	109	15	doct	doct	NOUN
admet-2603	109	16	,	,	PUNCT
admet-2603	109	17	ph	ph	VERB
admet-2603	109	18	6.5	6.5	NUM
admet-2603	109	19	>	>	SYM
admet-2603	109	20	0	0	NUM
admet-2603	109	21	)	)	PUNCT
admet-2603	109	22	were	be	AUX
admet-2603	109	23	lower	low	ADJ
admet-2603	109	24	in	in	ADP
admet-2603	109	25	bcb	bcb	PROPN
admet-2603	109	26	than	than	ADP
admet-2603	109	27	in	in	ADP
admet-2603	109	28	ppb	ppb	NOUN
admet-2603	109	29	(	(	PUNCT
admet-2603	109	30	figure	figure	NOUN
admet-2603	109	31	3	3	NUM
admet-2603	109	32	)	)	PUNCT
admet-2603	109	33	.	.	PUNCT
admet-2603	110	1	the	the	DET
admet-2603	110	2	pe	pe	PROPN
admet-2603	110	3	value	value	NOUN
admet-2603	110	4	of	of	ADP
admet-2603	110	5	a	a	DET
admet-2603	110	6	lipophilic	lipophilic	ADJ
admet-2603	110	7	weakly	weakly	ADJ
admet-2603	110	8	basic	basic	ADJ
admet-2603	110	9	drug	drug	NOUN
admet-2603	110	10	(	(	PUNCT
admet-2603	110	11	propranolol	propranolol	NOUN
admet-2603	110	12	)	)	PUNCT
admet-2603	110	13	was	be	AUX
admet-2603	110	14	also	also	ADV
admet-2603	110	15	lower	low	ADJ
admet-2603	110	16	in	in	ADP
admet-2603	110	17	bcb	bcb	PROPN
admet-2603	110	18	than	than	ADP
admet-2603	110	19	in	in	ADP
admet-2603	110	20	ppb	ppb	NOUN
admet-2603	110	21	(	(	PUNCT
admet-2603	110	22	figure	figure	NOUN
admet-2603	110	23	4c	4c	NOUN
admet-2603	110	24	)	)	PUNCT
admet-2603	110	25	.	.	PUNCT
admet-2603	111	1	on	on	ADP
admet-2603	111	2	the	the	DET
admet-2603	111	3	other	other	ADJ
admet-2603	111	4	hand	hand	NOUN
admet-2603	111	5	,	,	PUNCT
admet-2603	111	6	the	the	DET
admet-2603	111	7	pe	pe	PROPN
admet-2603	111	8	values	value	NOUN
admet-2603	111	9	of	of	ADP
admet-2603	111	10	unionizable	unionizable	ADJ
admet-2603	111	11	drugs	drug	NOUN
admet-2603	111	12	(	(	PUNCT
admet-2603	111	13	caffeine	caffeine	NOUN
admet-2603	111	14	and	and	CCONJ
admet-2603	111	15	antipyrine	antipyrine	VERB
admet-2603	111	16	)	)	PUNCT
admet-2603	111	17	in	in	ADP
admet-2603	111	18	bcb	bcb	PROPN
admet-2603	111	19	and	and	CCONJ
admet-2603	111	20	ppb	ppb	NOUN
admet-2603	111	21	were	be	AUX
admet-2603	111	22	similar	similar	ADJ
admet-2603	111	23	(	(	PUNCT
admet-2603	111	24	figure	figure	NOUN
admet-2603	111	25	5	5	NUM
admet-2603	111	26	)	)	PUNCT
admet-2603	111	27	.	.	PUNCT
admet-2603	112	1	the	the	DET
admet-2603	112	2	pe	pe	PROPN
admet-2603	112	3	values	value	NOUN
admet-2603	112	4	of	of	ADP
admet-2603	112	5	hydrophilic	hydrophilic	ADJ
admet-2603	112	6	weakly	weakly	ADJ
admet-2603	112	7	basic	basic	ADJ
admet-2603	112	8	drugs	drug	NOUN
admet-2603	112	9	(	(	PUNCT
admet-2603	112	10	metoprolol	metoprolol	NOUN
admet-2603	112	11	and	and	CCONJ
admet-2603	112	12	procainamide	procainamide	NOUN
admet-2603	112	13	,	,	PUNCT
admet-2603	112	14	log	log	VERB
admet-2603	112	15	doct	doct	NOUN
admet-2603	112	16	,	,	PUNCT
admet-2603	112	17	ph	ph	X
admet-2603	112	18	6.5	6.5	NUM
admet-2603	112	19	<	<	NOUN
admet-2603	112	20	0	0	NUM
admet-2603	112	21	)	)	PUNCT
admet-2603	112	22	in	in	ADP
admet-2603	112	23	bcb	bcb	PROPN
admet-2603	112	24	and	and	CCONJ
admet-2603	112	25	ppb	ppb	NOUN
admet-2603	112	26	were	be	AUX
admet-2603	112	27	also	also	ADV
admet-2603	112	28	similar	similar	ADJ
admet-2603	112	29	(	(	PUNCT
admet-2603	112	30	figures	figure	NOUN
admet-2603	112	31	4a	4a	NOUN
admet-2603	112	32	and	and	CCONJ
admet-2603	112	33	4b	4b	NUM
admet-2603	112	34	)	)	PUNCT
admet-2603	112	35	.	.	PUNCT
admet-2603	113	1	the	the	DET
admet-2603	113	2	flux	flux	PROPN
admet-2603	113	3	measurement	measurement	NOUN
admet-2603	113	4	was	be	AUX
admet-2603	113	5	also	also	ADV
admet-2603	113	6	performed	perform	VERB
admet-2603	113	7	for	for	ADP
admet-2603	113	8	a	a	DET
admet-2603	113	9	hydrophilic	hydrophilic	ADJ
admet-2603	113	10	weakly	weakly	ADJ
admet-2603	113	11	acid	acid	NOUN
admet-2603	113	12	drug	drug	NOUN
admet-2603	113	13	(	(	PUNCT
admet-2603	113	14	furosemide	furosemide	NOUN
admet-2603	113	15	)	)	PUNCT
admet-2603	113	16	.	.	PUNCT
admet-2603	114	1	however	however	ADV
admet-2603	114	2	,	,	PUNCT
admet-2603	114	3	the	the	DET
admet-2603	114	4	drug	drug	NOUN
admet-2603	114	5	was	be	AUX
admet-2603	114	6	not	not	PART
admet-2603	114	7	detected	detect	VERB
admet-2603	114	8	in	in	ADP
admet-2603	114	9	the	the	DET
admet-2603	114	10	acceptor	acceptor	NOUN
admet-2603	114	11	solution	solution	NOUN
admet-2603	114	12	even	even	ADV
admet-2603	114	13	when	when	SCONJ
admet-2603	114	14	the	the	DET
admet-2603	114	15	donor	donor	NOUN
admet-2603	114	16	concentration	concentration	NOUN
admet-2603	114	17	was	be	AUX
admet-2603	114	18	increased	increase	VERB
admet-2603	114	19	to	to	ADP
admet-2603	114	20	its	its	PRON
admet-2603	114	21	solubility	solubility	NOUN
admet-2603	114	22	limit	limit	NOUN
admet-2603	114	23	(	(	PUNCT
admet-2603	114	24	data	datum	NOUN
admet-2603	114	25	not	not	PART
admet-2603	114	26	shown	show	VERB
admet-2603	114	27	)	)	PUNCT
admet-2603	114	28	.	.	PUNCT
admet-2603	115	1	time	time	NOUN
admet-2603	115	2	,	,	PUNCT
admet-2603	115	3	min	min	PROPN
admet-2603	115	4	time	time	NOUN
admet-2603	115	5	,	,	PUNCT
admet-2603	115	6	min	min	NOUN
admet-2603	115	7	figure	figure	NOUN
admet-2603	115	8	3	3	NUM
admet-2603	115	9	.	.	PUNCT
admet-2603	115	10	concentration	concentration	NOUN
admet-2603	115	11	time	time	NOUN
admet-2603	115	12	profiles	profile	NOUN
admet-2603	115	13	of	of	ADP
admet-2603	115	14	weakly	weakly	ADJ
admet-2603	115	15	acidic	acidic	ADJ
admet-2603	115	16	drugs	drug	NOUN
admet-2603	115	17	in	in	ADP
admet-2603	115	18	the	the	DET
admet-2603	115	19	acceptor	acceptor	NOUN
admet-2603	115	20	chamber	chamber	NOUN
admet-2603	115	21	.	.	PUNCT
admet-2603	116	1	mean	mean	PROPN
admet-2603	116	2	±	±	NUM
admet-2603	116	3	s.d	s.d	PROPN
admet-2603	116	4	.	.	PROPN
admet-2603	116	5	,	,	PUNCT
admet-2603	116	6	n	n	PROPN
admet-2603	116	7	=	=	SYM
admet-2603	116	8	3	3	X
admet-2603	116	9	.	.	PUNCT
admet-2603	117	1	c	c	NOUN
admet-2603	117	2	o	o	PROPN
admet-2603	117	3	n	n	X
admet-2603	117	4	ce	ce	PROPN
admet-2603	117	5	n	n	CCONJ
admet-2603	117	6	tr	tr	VERB
admet-2603	117	7	at	at	ADP
admet-2603	117	8	io	io	X
admet-2603	117	9	n	n	PROPN
admet-2603	117	10	,	,	PUNCT
admet-2603	117	11	m	m	VERB
admet-2603	117	12	g	g	NOUN
admet-2603	117	13	m	m	PROPN
admet-2603	117	14	l-1	l-1	NOUN
admet-2603	117	15	c	c	NOUN
admet-2603	117	16	o	o	PROPN
admet-2603	117	17	n	n	X
admet-2603	117	18	ce	ce	PROPN
admet-2603	117	19	n	n	CCONJ
admet-2603	117	20	tr	tr	VERB
admet-2603	117	21	at	at	ADP
admet-2603	117	22	io	io	X
admet-2603	117	23	n	n	PROPN
admet-2603	117	24	,	,	PUNCT
admet-2603	117	25	m	m	VERB
admet-2603	117	26	g	g	PROPN
admet-2603	117	27	m	m	PROPN
admet-2603	117	28	l-1	l-1	PROPN
admet-2603	117	29	admet	admet	PROPN
admet-2603	117	30	&	&	CCONJ
admet-2603	117	31	dmpk	dmpk	PROPN
admet-2603	117	32	13(1	13(1	NUM
admet-2603	117	33	)	)	PUNCT
admet-2603	117	34	(	(	PUNCT
admet-2603	117	35	2025	2025	NUM
admet-2603	117	36	)	)	PUNCT
admet-2603	117	37	2603	2603	NUM
admet-2603	117	38	effect	effect	NOUN
admet-2603	117	39	of	of	ADP
admet-2603	117	40	bicarbonate	bicarbonate	NOUN
admet-2603	117	41	buffer	buffer	NOUN
admet-2603	117	42	on	on	ADP
admet-2603	117	43	artificial	artificial	ADJ
admet-2603	117	44	membrane	membrane	NOUN
admet-2603	117	45	permeation	permeation	NOUN
admet-2603	117	46	of	of	ADP
admet-2603	117	47	drugs	drug	NOUN
admet-2603	117	48	doi	doi	PROPN
admet-2603	117	49	:	:	PUNCT
admet-2603	117	50	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	117	51	5	5	NUM
admet-2603	117	52	time	time	NOUN
admet-2603	117	53	,	,	PUNCT
admet-2603	117	54	min	min	PROPN
admet-2603	117	55	time	time	NOUN
admet-2603	117	56	,	,	PUNCT
admet-2603	117	57	min	min	PROPN
admet-2603	117	58	time	time	NOUN
admet-2603	117	59	,	,	PUNCT
admet-2603	117	60	min	min	NOUN
admet-2603	117	61	figure	figure	NOUN
admet-2603	117	62	4	4	NUM
admet-2603	117	63	.	.	PUNCT
admet-2603	117	64	concentration	concentration	NOUN
admet-2603	117	65	time	time	NOUN
admet-2603	117	66	profiles	profile	NOUN
admet-2603	117	67	of	of	ADP
admet-2603	117	68	weakly	weakly	ADJ
admet-2603	117	69	basic	basic	ADJ
admet-2603	117	70	drugs	drug	NOUN
admet-2603	117	71	in	in	ADP
admet-2603	117	72	the	the	DET
admet-2603	117	73	acceptor	acceptor	NOUN
admet-2603	117	74	chamber	chamber	NOUN
admet-2603	117	75	.	.	PUNCT
admet-2603	118	1	mean	mean	PROPN
admet-2603	118	2	±	±	NUM
admet-2603	118	3	s.d	s.d	PROPN
admet-2603	118	4	.	.	PROPN
admet-2603	118	5	,	,	PUNCT
admet-2603	118	6	n	n	PROPN
admet-2603	118	7	=	=	SYM
admet-2603	118	8	3	3	NUM
admet-2603	118	9	.	.	NOUN
admet-2603	118	10	time	time	NOUN
admet-2603	118	11	,	,	PUNCT
admet-2603	118	12	min	min	PROPN
admet-2603	118	13	time	time	NOUN
admet-2603	118	14	,	,	PUNCT
admet-2603	118	15	min	min	NOUN
admet-2603	118	16	figure	figure	NOUN
admet-2603	118	17	5	5	NUM
admet-2603	118	18	.	.	PUNCT
admet-2603	118	19	concentration	concentration	NOUN
admet-2603	118	20	time	time	NOUN
admet-2603	118	21	profiles	profile	NOUN
admet-2603	118	22	of	of	ADP
admet-2603	118	23	unionizable	unionizable	ADJ
admet-2603	118	24	drugs	drug	NOUN
admet-2603	118	25	in	in	ADP
admet-2603	118	26	the	the	DET
admet-2603	118	27	acceptor	acceptor	NOUN
admet-2603	118	28	chamber	chamber	NOUN
admet-2603	118	29	.	.	PUNCT
admet-2603	119	1	mean	mean	PROPN
admet-2603	119	2	±	±	NUM
admet-2603	119	3	s.d	s.d	PROPN
admet-2603	119	4	.	.	PROPN
admet-2603	119	5	,	,	PUNCT
admet-2603	119	6	n	n	PROPN
admet-2603	119	7	=	=	SYM
admet-2603	119	8	3	3	X
admet-2603	119	9	.	.	NOUN
admet-2603	119	10	table	table	NOUN
admet-2603	119	11	2	2	NUM
admet-2603	119	12	.	.	X
admet-2603	119	13	flux	flux	NOUN
admet-2603	119	14	and	and	CCONJ
admet-2603	119	15	permeability	permeability	NOUN
admet-2603	119	16	dataa	dataa	ADJ
admet-2603	119	17	drug	drug	NOUN
admet-2603	119	18	name	name	NOUN
admet-2603	119	19	(	(	PUNCT
admet-2603	119	20	cd	cd	PROPN
admet-2603	119	21	,	,	PUNCT
admet-2603	119	22	init	init	VERB
admet-2603	119	23	/	/	PUNCT
admet-2603	119	24	mg	mg	PROPN
admet-2603	119	25	ml-1	ml-1	CCONJ
admet-2603	119	26	)	)	PUNCT
admet-2603	119	27	buffer	buffer	NOUN
admet-2603	119	28	j	j	PROPN
admet-2603	119	29	/	/	SYM
admet-2603	119	30	μg	μg	PROPN
admet-2603	119	31	cm-2	cm-2	VERB
admet-2603	119	32	min-1	min-1	PROPN
admet-2603	119	33	pe	pe	PROPN
admet-2603	119	34	/	/	SYM
admet-2603	119	35	10	10	NUM
admet-2603	119	36	-	-	SYM
admet-2603	119	37	6	6	NUM
admet-2603	119	38	cm	cm	NOUN
admet-2603	119	39	s-1	s-1	NOUN
admet-2603	119	40	final	final	ADJ
admet-2603	119	41	ph	ph	NOUN
admet-2603	119	42	(	(	PUNCT
admet-2603	119	43	at	at	ADP
admet-2603	119	44	120	120	NUM
admet-2603	119	45	min	min	NOUN
admet-2603	119	46	)	)	PUNCT
admet-2603	119	47	donor	donor	NOUN
admet-2603	119	48	acceptor	acceptor	NOUN
admet-2603	119	49	antipyrine	antipyrine	NOUN
admet-2603	119	50	ppb	ppb	VERB
admet-2603	119	51	1.27	1.27	NUM
admet-2603	119	52	±	±	NUM
admet-2603	119	53	0.04	0.04	NUM
admet-2603	119	54	2.27	2.27	NUM
admet-2603	119	55	±	±	NUM
admet-2603	119	56	0.06	0.06	NUM
admet-2603	119	57	6.50	6.50	NUM
admet-2603	119	58	±	±	NUM
admet-2603	119	59	0.02	0.02	NUM
admet-2603	119	60	6.50	6.50	NUM
admet-2603	119	61	±	±	NUM
admet-2603	119	62	0.01	0.01	NUM
admet-2603	119	63	(	(	PUNCT
admet-2603	119	64	5.0	5.0	NUM
admet-2603	119	65	mg	mg	NUM
admet-2603	119	66	/	/	SYM
admet-2603	119	67	ml	ml	NOUN
admet-2603	119	68	)	)	PUNCT
admet-2603	119	69	bcb	bcb	PROPN
admet-2603	119	70	1.17	1.17	NUM
admet-2603	119	71	±	±	NUM
admet-2603	119	72	0.03	0.03	NUM
admet-2603	119	73	2.14	2.14	NUM
admet-2603	119	74	±	±	NUM
admet-2603	119	75	0.07	0.07	NUM
admet-2603	119	76	6.57	6.57	NUM
admet-2603	119	77	±	±	NUM
admet-2603	119	78	0.03	0.03	NUM
admet-2603	119	79	6.58	6.58	NUM
admet-2603	119	80	±	±	NUM
admet-2603	119	81	0.02	0.02	NUM
admet-2603	119	82	caffeine	caffeine	NOUN
admet-2603	119	83	ppb	ppb	VERB
admet-2603	119	84	2.05	2.05	NUM
admet-2603	119	85	±	±	NUM
admet-2603	119	86	0.09	0.09	NUM
admet-2603	119	87	3.54	3.54	NUM
admet-2603	119	88	±	±	NUM
admet-2603	119	89	0.19	0.19	NUM
admet-2603	119	90	6.53	6.53	NUM
admet-2603	119	91	±	±	NUM
admet-2603	119	92	0.02	0.02	NUM
admet-2603	119	93	6.48	6.48	NUM
admet-2603	119	94	±	±	NUM
admet-2603	119	95	0.00	0.00	NUM
admet-2603	119	96	(	(	PUNCT
admet-2603	119	97	10	10	NUM
admet-2603	119	98	mg	mg	NUM
admet-2603	119	99	/	/	SYM
admet-2603	119	100	ml	ml	NOUN
admet-2603	119	101	)	)	PUNCT
admet-2603	119	102	bcb	bcb	PROPN
admet-2603	119	103	1.97	1.97	NUM
admet-2603	119	104	±	±	NUM
admet-2603	119	105	0.09	0.09	NUM
admet-2603	119	106	3.39	3.39	NUM
admet-2603	119	107	±	±	NUM
admet-2603	119	108	0.12	0.12	NUM
admet-2603	119	109	6.55	6.55	NUM
admet-2603	119	110	±	±	NUM
admet-2603	119	111	0.02	0.02	NUM
admet-2603	119	112	6.54	6.54	NUM
admet-2603	119	113	±	±	NUM
admet-2603	119	114	0.01	0.01	NUM
admet-2603	119	115	ketoprofen	ketoprofen	NOUN
admet-2603	119	116	ppb	ppb	NOUN
admet-2603	119	117	0.465	0.465	NUM
admet-2603	119	118	±	±	NOUN
admet-2603	119	119	0.016	0.016	NUM
admet-2603	119	120	7.33	7.33	NUM
admet-2603	119	121	±	±	NUM
admet-2603	119	122	0.28	0.28	NUM
admet-2603	119	123	6.46	6.46	NUM
admet-2603	119	124	±	±	NUM
admet-2603	119	125	0.02	0.02	NUM
admet-2603	119	126	6.47	6.47	NUM
admet-2603	119	127	±	±	NUM
admet-2603	119	128	0.00	0.00	NUM
admet-2603	119	129	(	(	PUNCT
admet-2603	119	130	1.0	1.0	NUM
admet-2603	119	131	mg	mg	NUM
admet-2603	119	132	/	/	SYM
admet-2603	119	133	ml	ml	NOUN
admet-2603	119	134	)	)	PUNCT
admet-2603	119	135	bcb	bcb	PROPN
admet-2603	119	136	0.280	0.280	NUM
admet-2603	119	137	±	±	NUM
admet-2603	119	138	0.017	0.017	NUM
admet-2603	119	139	6.01	6.01	NUM
admet-2603	119	140	±	±	NUM
admet-2603	119	141	0.44	0.44	NUM
admet-2603	119	142	6.59	6.59	NUM
admet-2603	119	143	±	±	NUM
admet-2603	119	144	0.01	0.01	NUM
admet-2603	119	145	6.46	6.46	NUM
admet-2603	119	146	±	±	NUM
admet-2603	119	147	0.01	0.01	NUM
admet-2603	119	148	metoprolol	metoprolol	NOUN
admet-2603	119	149	ppb	ppb	NOUN
admet-2603	119	150	0.889	0.889	NUM
admet-2603	119	151	±	±	NUM
admet-2603	119	152	0.062	0.062	NUM
admet-2603	119	153	14.8	14.8	NUM
admet-2603	119	154	±	±	NUM
admet-2603	119	155	1.0	1.0	NUM
admet-2603	119	156	6.46	6.46	NUM
admet-2603	119	157	±	±	NUM
admet-2603	119	158	0.02	0.02	NUM
admet-2603	119	159	6.45	6.45	NUM
admet-2603	119	160	±	±	NUM
admet-2603	119	161	0.01	0.01	NUM
admet-2603	119	162	(	(	PUNCT
admet-2603	119	163	1.0	1.0	NUM
admet-2603	119	164	mg	mg	NUM
admet-2603	119	165	/	/	SYM
admet-2603	119	166	ml	ml	NOUN
admet-2603	119	167	)	)	PUNCT
admet-2603	119	168	bcb	bcb	PROPN
admet-2603	119	169	0.902	0.902	NUM
admet-2603	119	170	±	±	NUM
admet-2603	119	171	0.044	0.044	NUM
admet-2603	119	172	14.4	14.4	NUM
admet-2603	119	173	±	±	NUM
admet-2603	119	174	0.7	0.7	NUM
admet-2603	119	175	6.62	6.62	NUM
admet-2603	119	176	±	±	NUM
admet-2603	119	177	0.03	0.03	NUM
admet-2603	119	178	6.59	6.59	NUM
admet-2603	119	179	±	±	NUM
admet-2603	119	180	0.00	0.00	NUM
admet-2603	119	181	naproxen	naproxen	NOUN
admet-2603	119	182	ppb	ppb	NOUN
admet-2603	119	183	0.888	0.888	NUM
admet-2603	119	184	±	±	NUM
admet-2603	119	185	0.030	0.030	NUM
admet-2603	119	186	14.7	14.7	NUM
admet-2603	119	187	±	±	NUM
admet-2603	119	188	0.5	0.5	NUM
admet-2603	119	189	6.50	6.50	NUM
admet-2603	119	190	±	±	NUM
admet-2603	119	191	0.02	0.02	NUM
admet-2603	119	192	6.47	6.47	NUM
admet-2603	119	193	±	±	NUM
admet-2603	119	194	0.02	0.02	NUM
admet-2603	119	195	(	(	PUNCT
admet-2603	119	196	1.0	1.0	NUM
admet-2603	119	197	mg	mg	NUM
admet-2603	119	198	/	/	SYM
admet-2603	119	199	ml	ml	NOUN
admet-2603	119	200	)	)	PUNCT
admet-2603	119	201	bcb	bcb	PROPN
admet-2603	119	202	0.637	0.637	NUM
admet-2603	119	203	±	±	NUM
admet-2603	119	204	0.005	0.005	NUM
admet-2603	119	205	10.8	10.8	NUM
admet-2603	119	206	±	±	NUM
admet-2603	119	207	0.9	0.9	NUM
admet-2603	119	208	6.62	6.62	NUM
admet-2603	119	209	±	±	NUM
admet-2603	119	210	0.01	0.01	NUM
admet-2603	119	211	6.63	6.63	NUM
admet-2603	119	212	±	±	NUM
admet-2603	119	213	0.01	0.01	NUM
admet-2603	119	214	procainamide	procainamide	ADJ
admet-2603	119	215	ppb	ppb	VERB
admet-2603	119	216	0.594	0.594	NUM
admet-2603	119	217	±	±	NUM
admet-2603	119	218	0.013	0.013	NUM
admet-2603	119	219	1.05	1.05	NUM
admet-2603	119	220	±	±	NUM
admet-2603	119	221	0.02	0.02	NUM
admet-2603	119	222	6.46	6.46	NUM
admet-2603	119	223	±	±	NUM
admet-2603	119	224	0.03	0.03	NUM
admet-2603	119	225	6.46	6.46	NUM
admet-2603	119	226	±	±	NUM
admet-2603	119	227	0.00	0.00	NUM
admet-2603	119	228	(	(	PUNCT
admet-2603	119	229	10	10	NUM
admet-2603	119	230	mg	mg	NUM
admet-2603	119	231	/	/	SYM
admet-2603	119	232	ml	ml	NOUN
admet-2603	119	233	)	)	PUNCT
admet-2603	119	234	bcb	bcb	PROPN
admet-2603	119	235	0.594	0.594	NUM
admet-2603	119	236	±	±	NUM
admet-2603	119	237	0.014	0.014	NUM
admet-2603	119	238	1.05	1.05	NUM
admet-2603	119	239	±	±	NUM
admet-2603	119	240	0.03	0.03	NUM
admet-2603	119	241	6.64	6.64	NUM
admet-2603	119	242	±	±	NUM
admet-2603	119	243	0.04	0.04	NUM
admet-2603	119	244	6.62	6.62	NUM
admet-2603	119	245	±	±	NUM
admet-2603	119	246	0.00	0.00	NUM
admet-2603	119	247	propranolol	propranolol	NOUN
admet-2603	119	248	ppb	ppb	VERB
admet-2603	119	249	1.22	1.22	NUM
admet-2603	119	250	±	±	NUM
admet-2603	119	251	0.03	0.03	NUM
admet-2603	119	252	43.5	43.5	NUM
admet-2603	119	253	±	±	NUM
admet-2603	119	254	0.9	0.9	NUM
admet-2603	119	255	6.47	6.47	NUM
admet-2603	119	256	±	±	NUM
admet-2603	119	257	0.03	0.03	NUM
admet-2603	119	258	6.46	6.46	NUM
admet-2603	119	259	±	±	NUM
admet-2603	119	260	0.01	0.01	NUM
admet-2603	119	261	(	(	PUNCT
admet-2603	119	262	0.5	0.5	NUM
admet-2603	119	263	mg	mg	PROPN
admet-2603	119	264	/	/	SYM
admet-2603	119	265	ml	ml	NOUN
admet-2603	119	266	)	)	PUNCT
admet-2603	119	267	bcb	bcb	PROPN
admet-2603	119	268	0.956	0.956	NUM
admet-2603	119	269	±	±	NUM
admet-2603	119	270	0.030	0.030	NUM
admet-2603	119	271	33.3	33.3	NUM
admet-2603	119	272	±	±	NUM
admet-2603	119	273	1.0	1.0	NUM
admet-2603	119	274	6.56	6.56	NUM
admet-2603	119	275	±	±	NUM
admet-2603	119	276	0.01	0.01	NUM
admet-2603	119	277	6.60	6.60	NUM
admet-2603	119	278	±	±	NUM
admet-2603	119	279	0.01	0.01	NUM
admet-2603	119	280	amean	amean	PROPN
admet-2603	119	281	±	±	PROPN
admet-2603	119	282	s.d	s.d	PROPN
admet-2603	119	283	.	.	PROPN
admet-2603	119	284	,	,	PUNCT
admet-2603	119	285	n	n	PROPN
admet-2603	119	286	=	=	SYM
admet-2603	119	287	3	3	X
admet-2603	119	288	.	.	NOUN
admet-2603	119	289	furosemide	furosemide	ADJ
admet-2603	119	290	data	datum	NOUN
admet-2603	119	291	was	be	AUX
admet-2603	119	292	not	not	PART
admet-2603	119	293	shown	show	VERB
admet-2603	119	294	as	as	SCONJ
admet-2603	119	295	it	it	PRON
admet-2603	119	296	was	be	AUX
admet-2603	119	297	not	not	PART
admet-2603	119	298	detected	detect	VERB
admet-2603	119	299	in	in	ADP
admet-2603	119	300	the	the	DET
admet-2603	119	301	acceptor	acceptor	NOUN
admet-2603	119	302	solution	solution	NOUN
admet-2603	119	303	.	.	PUNCT
admet-2603	120	1	in	in	ADP
admet-2603	120	2	this	this	DET
admet-2603	120	3	study	study	NOUN
admet-2603	120	4	,	,	PUNCT
admet-2603	120	5	it	it	PRON
admet-2603	120	6	was	be	AUX
admet-2603	120	7	found	find	VERB
admet-2603	120	8	for	for	ADP
admet-2603	120	9	the	the	DET
admet-2603	120	10	first	first	ADJ
admet-2603	120	11	time	time	NOUN
admet-2603	120	12	that	that	SCONJ
admet-2603	120	13	the	the	DET
admet-2603	120	14	effective	effective	ADJ
admet-2603	120	15	permeability	permeability	NOUN
admet-2603	120	16	of	of	ADP
admet-2603	120	17	lipophilic	lipophilic	ADJ
admet-2603	120	18	weakly	weakly	ADJ
admet-2603	120	19	acidic	acidic	ADJ
admet-2603	120	20	and	and	CCONJ
admet-2603	120	21	basic	basic	ADJ
admet-2603	120	22	drugs	drug	NOUN
admet-2603	120	23	(	(	PUNCT
admet-2603	120	24	ketoprofen	ketoprofen	VERB
admet-2603	120	25	,	,	PUNCT
admet-2603	120	26	naproxen	naproxen	NOUN
admet-2603	120	27	,	,	PUNCT
admet-2603	120	28	propranolol	propranolol	PROPN
admet-2603	120	29	)	)	PUNCT
admet-2603	120	30	(	(	PUNCT
admet-2603	120	31	log	log	PROPN
admet-2603	120	32	doct	doct	NOUN
admet-2603	120	33	,	,	PUNCT
admet-2603	120	34	ph	ph	VERB
admet-2603	120	35	6.5	6.5	NUM
admet-2603	120	36	>	>	SYM
admet-2603	120	37	0	0	NUM
admet-2603	120	38	)	)	PUNCT
admet-2603	120	39	was	be	AUX
admet-2603	120	40	slower	slow	ADJ
admet-2603	120	41	in	in	ADP
admet-2603	120	42	bcb	bcb	PROPN
admet-2603	120	43	than	than	ADP
admet-2603	120	44	in	in	ADP
admet-2603	120	45	ppb	ppb	NOUN
admet-2603	120	46	.	.	PUNCT
admet-2603	121	1	pe	pe	PROPN
admet-2603	121	2	is	be	AUX
admet-2603	121	3	determined	determine	VERB
admet-2603	121	4	as	as	ADP
admet-2603	121	5	the	the	DET
admet-2603	121	6	sum	sum	NOUN
admet-2603	121	7	of	of	ADP
admet-2603	121	8	the	the	DET
admet-2603	121	9	reciprocals	reciprocal	NOUN
admet-2603	121	10	of	of	ADP
admet-2603	121	11	the	the	DET
admet-2603	121	12	unstirred	unstirred	ADJ
admet-2603	121	13	water	water	NOUN
admet-2603	121	14	layer	layer	NOUN
admet-2603	121	15	(	(	PUNCT
admet-2603	121	16	uwl	uwl	NOUN
admet-2603	121	17	)	)	PUNCT
admet-2603	121	18	permeability	permeability	NOUN
admet-2603	121	19	(	(	PUNCT
admet-2603	121	20	puwl	puwl	PROPN
admet-2603	121	21	)	)	PUNCT
admet-2603	121	22	adjacent	adjacent	ADJ
admet-2603	121	23	to	to	ADP
admet-2603	121	24	the	the	DET
admet-2603	121	25	membrane	membrane	NOUN
admet-2603	121	26	and	and	CCONJ
admet-2603	121	27	the	the	DET
admet-2603	121	28	membrane	membrane	NOUN
admet-2603	121	29	permeability	permeability	NOUN
admet-2603	121	30	(	(	PUNCT
admet-2603	121	31	pm	pm	NOUN
admet-2603	121	32	)	)	PUNCT
admet-2603	121	33	(	(	PUNCT
admet-2603	121	34	1/	1/	NUM
admet-2603	121	35	pe	pe	NOUN
admet-2603	121	36	=	=	SYM
admet-2603	121	37	1/	1/	NUM
admet-2603	121	38	puwl	puwl	NOUN
admet-2603	121	39	+	+	CCONJ
admet-2603	121	40	1/	1/	NUM
admet-2603	121	41	pm	pm	NOUN
admet-2603	121	42	)	)	PUNCT
admet-2603	121	43	.	.	PUNCT
admet-2603	122	1	puwl	puwl	PROPN
admet-2603	122	2	can	can	AUX
admet-2603	122	3	be	be	AUX
admet-2603	122	4	calculated	calculate	VERB
admet-2603	122	5	from	from	ADP
admet-2603	122	6	the	the	DET
admet-2603	122	7	diffusion	diffusion	NOUN
admet-2603	122	8	coefficient	coefficient	NOUN
admet-2603	122	9	of	of	ADP
admet-2603	122	10	a	a	DET
admet-2603	122	11	monomer	monomer	NOUN
admet-2603	122	12	drug	drug	NOUN
admet-2603	122	13	(	(	PUNCT
admet-2603	122	14	dmono	dmono	NOUN
admet-2603	122	15	)	)	PUNCT
admet-2603	122	16	and	and	CCONJ
admet-2603	122	17	the	the	DET
admet-2603	122	18	thickness	thickness	NOUN
admet-2603	122	19	of	of	ADP
admet-2603	122	20	the	the	DET
admet-2603	122	21	uwl	uwl	NOUN
admet-2603	122	22	(	(	PUNCT
admet-2603	122	23	huwl	huwl	NOUN
admet-2603	122	24	)	)	PUNCT
admet-2603	122	25	as	as	ADP
admet-2603	122	26	puwl	puwl	NOUN
admet-2603	122	27	=	=	PUNCT
admet-2603	122	28	dmono	dmono	NOUN
admet-2603	122	29	/	/	SYM
admet-2603	122	30	huwl	huwl	NOUN
admet-2603	122	31	.	.	PUNCT
admet-2603	123	1	the	the	DET
admet-2603	123	2	huwl	huwl	NOUN
admet-2603	123	3	value	value	NOUN
admet-2603	123	4	at	at	ADP
admet-2603	123	5	150	150	NUM
admet-2603	123	6	rpm	rpm	NOUN
admet-2603	123	7	was	be	AUX
admet-2603	123	8	calculated	calculate	VERB
admet-2603	123	9	to	to	PART
admet-2603	123	10	be	be	AUX
admet-2603	123	11	164	164	NUM
admet-2603	123	12	μm	μm	NOUN
admet-2603	123	13	by	by	ADP
admet-2603	123	14	the	the	DET
admet-2603	123	15	rpm	rpm	PROPN
admet-2603	123	16	-	-	PUNCT
admet-2603	123	17	to	to	ADP
admet-2603	123	18	-	-	PUNCT
admet-2603	123	19	huwl	huwl	NOUN
admet-2603	123	20	converter	converter	NOUN
admet-2603	123	21	provided	provide	VERB
admet-2603	123	22	by	by	ADP
admet-2603	123	23	pion	pion	PROPN
admet-2603	123	24	inc	inc	PROPN
admet-2603	123	25	.	.	PROPN
admet-2603	123	26	dmono	dmono	PROPN
admet-2603	123	27	can	can	AUX
admet-2603	123	28	be	be	AUX
admet-2603	123	29	estimated	estimate	VERB
admet-2603	123	30	from	from	ADP
admet-2603	123	31	mw	mw	PROPN
admet-2603	123	32	(	(	PUNCT
admet-2603	123	33	table	table	NOUN
admet-2603	123	34	1	1	NUM
admet-2603	123	35	)	)	PUNCT
admet-2603	123	36	.	.	PUNCT
admet-2603	124	1	for	for	ADP
admet-2603	124	2	all	all	DET
admet-2603	124	3	model	model	NOUN
admet-2603	124	4	drugs	drug	NOUN
admet-2603	124	5	,	,	PUNCT
admet-2603	124	6	puwl	puwl	PROPN
admet-2603	124	7	was	be	AUX
admet-2603	124	8	calculated	calculate	VERB
admet-2603	124	9	to	to	PART
admet-2603	124	10	be	be	AUX
admet-2603	124	11	greater	great	ADJ
admet-2603	124	12	than	than	ADP
admet-2603	124	13	4×10	4×10	NUM
admet-2603	124	14	-	-	SYM
admet-2603	124	15	4	4	NUM
admet-2603	124	16	cm	cm	NUM
admet-2603	124	17	s-1	s-1	NOUN
admet-2603	124	18	.	.	PUNCT
admet-2603	125	1	therefore	therefore	ADV
admet-2603	125	2	,	,	PUNCT
admet-2603	125	3	pe	pe	PROPN
admet-2603	125	4	was	be	AUX
admet-2603	125	5	lower	low	ADJ
admet-2603	125	6	than	than	ADP
admet-2603	125	7	puwl	puwl	NOUN
admet-2603	125	8	and	and	CCONJ
admet-2603	125	9	the	the	DET
admet-2603	125	10	membrane	membrane	NOUN
admet-2603	125	11	permeation	permeation	NOUN
admet-2603	125	12	was	be	AUX
admet-2603	125	13	the	the	DET
admet-2603	125	14	rate	rate	NOUN
admet-2603	125	15	-	-	PUNCT
admet-2603	125	16	limiting	limit	VERB
admet-2603	125	17	process	process	NOUN
admet-2603	125	18	in	in	ADP
admet-2603	125	19	all	all	DET
admet-2603	125	20	cases	case	NOUN
admet-2603	125	21	(	(	PUNCT
admet-2603	125	22	pe	pe	PROPN
admet-2603	125	23	≈	≈	PROPN
admet-2603	125	24	pm	pm	PROPN
admet-2603	125	25	)	)	PUNCT
admet-2603	125	26	.	.	PUNCT
admet-2603	126	1	therefore	therefore	ADV
admet-2603	126	2	,	,	PUNCT
admet-2603	126	3	the	the	DET
admet-2603	126	4	difference	difference	NOUN
admet-2603	126	5	in	in	ADP
admet-2603	126	6	pe	pe	PROPN
admet-2603	126	7	between	between	ADP
admet-2603	126	8	bcb	bcb	PROPN
admet-2603	126	9	and	and	CCONJ
admet-2603	126	10	ppb	ppb	NOUN
admet-2603	126	11	was	be	AUX
admet-2603	126	12	suggested	suggest	VERB
admet-2603	126	13	to	to	PART
admet-2603	126	14	be	be	AUX
admet-2603	126	15	attributed	attribute	VERB
admet-2603	126	16	to	to	ADP
admet-2603	126	17	their	their	PRON
admet-2603	126	18	different	different	ADJ
admet-2603	126	19	effects	effect	NOUN
admet-2603	126	20	on	on	ADP
admet-2603	126	21	the	the	DET
admet-2603	126	22	ph	ph	ADJ
admet-2603	126	23	value	value	NOUN
admet-2603	126	24	adjacent	adjacent	ADJ
admet-2603	126	25	to	to	ADP
admet-2603	126	26	the	the	DET
admet-2603	126	27	membrane	membrane	NOUN
admet-2603	126	28	surface	surface	NOUN
admet-2603	126	29	(	(	PUNCT
admet-2603	126	30	phms	phm	NOUN
admet-2603	126	31	)	)	PUNCT
admet-2603	126	32	.	.	PUNCT
admet-2603	127	1	c	c	NOUN
admet-2603	128	1	o	o	PROPN
admet-2603	128	2	n	n	X
admet-2603	128	3	ce	ce	PROPN
admet-2603	128	4	n	n	CCONJ
admet-2603	128	5	tr	tr	VERB
admet-2603	128	6	at	at	ADP
admet-2603	128	7	io	io	X
admet-2603	128	8	n	n	PROPN
admet-2603	128	9	,	,	PUNCT
admet-2603	128	10	m	m	VERB
admet-2603	128	11	g	g	NOUN
admet-2603	128	12	m	m	PROPN
admet-2603	128	13	l-1	l-1	NOUN
admet-2603	128	14	c	c	NOUN
admet-2603	128	15	o	o	PROPN
admet-2603	128	16	n	n	X
admet-2603	128	17	ce	ce	PROPN
admet-2603	128	18	n	n	CCONJ
admet-2603	128	19	tr	tr	VERB
admet-2603	128	20	at	at	ADP
admet-2603	128	21	io	io	X
admet-2603	128	22	n	n	PROPN
admet-2603	128	23	,	,	PUNCT
admet-2603	128	24	m	m	VERB
admet-2603	128	25	g	g	NOUN
admet-2603	128	26	m	m	PROPN
admet-2603	128	27	l-1	l-1	NOUN
admet-2603	128	28	c	c	NOUN
admet-2603	128	29	o	o	PROPN
admet-2603	128	30	n	n	X
admet-2603	128	31	ce	ce	PROPN
admet-2603	128	32	n	n	CCONJ
admet-2603	128	33	tr	tr	VERB
admet-2603	128	34	at	at	ADP
admet-2603	128	35	io	io	X
admet-2603	128	36	n	n	PROPN
admet-2603	128	37	,	,	PUNCT
admet-2603	128	38	m	m	VERB
admet-2603	128	39	g	g	NOUN
admet-2603	128	40	m	m	PROPN
admet-2603	128	41	l-1	l-1	NOUN
admet-2603	128	42	c	c	NOUN
admet-2603	128	43	o	o	PROPN
admet-2603	128	44	n	n	X
admet-2603	128	45	ce	ce	PROPN
admet-2603	128	46	n	n	CCONJ
admet-2603	128	47	tr	tr	VERB
admet-2603	128	48	at	at	ADP
admet-2603	128	49	io	io	X
admet-2603	128	50	n	n	PROPN
admet-2603	128	51	,	,	PUNCT
admet-2603	128	52	m	m	VERB
admet-2603	128	53	g	g	NOUN
admet-2603	128	54	m	m	PROPN
admet-2603	128	55	l-1	l-1	NOUN
admet-2603	128	56	c	c	NOUN
admet-2603	128	57	o	o	PROPN
admet-2603	128	58	n	n	X
admet-2603	128	59	ce	ce	PROPN
admet-2603	128	60	n	n	CCONJ
admet-2603	128	61	tr	tr	VERB
admet-2603	128	62	at	at	ADP
admet-2603	128	63	io	io	X
admet-2603	128	64	n	n	PROPN
admet-2603	128	65	,	,	PUNCT
admet-2603	128	66	m	m	VERB
admet-2603	128	67	g	g	NOUN
admet-2603	128	68	m	m	PROPN
admet-2603	128	69	l-1	l-1	PROPN
admet-2603	128	70	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	PROPN
admet-2603	128	71	s.	s.	PROPN
admet-2603	128	72	ishida	ishida	PROPN
admet-2603	128	73	et	et	PROPN
admet-2603	128	74	al	al	PROPN
admet-2603	128	75	.	.	PROPN
admet-2603	128	76	admet	admet	PROPN
admet-2603	128	77	&	&	CCONJ
admet-2603	128	78	dmpk	dmpk	PROPN
admet-2603	128	79	13(1	13(1	NUM
admet-2603	128	80	)	)	PUNCT
admet-2603	128	81	(	(	PUNCT
admet-2603	128	82	2025	2025	NUM
admet-2603	128	83	)	)	PUNCT
admet-2603	128	84	2603	2603	NUM
admet-2603	128	85	6	6	NUM
admet-2603	128	86	according	accord	VERB
admet-2603	128	87	to	to	ADP
admet-2603	128	88	the	the	DET
admet-2603	128	89	ph	ph	ADJ
admet-2603	128	90	partition	partition	NOUN
admet-2603	128	91	theory	theory	NOUN
admet-2603	128	92	,	,	PUNCT
admet-2603	128	93	only	only	ADV
admet-2603	128	94	unionized	unionize	VERB
admet-2603	128	95	species	specie	NOUN
admet-2603	128	96	can	can	AUX
admet-2603	128	97	permeate	permeate	VERB
admet-2603	128	98	a	a	DET
admet-2603	128	99	lipid	lipid	ADJ
admet-2603	128	100	membrane	membrane	NOUN
admet-2603	128	101	(	(	PUNCT
admet-2603	128	102	figure	figure	NOUN
admet-2603	128	103	6	6	NUM
admet-2603	128	104	)	)	PUNCT
admet-2603	128	105	.	.	PUNCT
admet-2603	129	1	therefore	therefore	ADV
admet-2603	129	2	,	,	PUNCT
admet-2603	129	3	the	the	DET
admet-2603	129	4	unionized	unionized	ADJ
admet-2603	129	5	fraction	fraction	NOUN
admet-2603	129	6	(	(	PUNCT
admet-2603	129	7	f0	f0	PROPN
admet-2603	129	8	)	)	PUNCT
admet-2603	129	9	of	of	ADP
admet-2603	129	10	a	a	DET
admet-2603	129	11	drug	drug	NOUN
admet-2603	129	12	at	at	ADP
admet-2603	129	13	the	the	DET
admet-2603	129	14	membrane	membrane	NOUN
admet-2603	129	15	surface	surface	NOUN
admet-2603	129	16	affects	affect	VERB
admet-2603	129	17	pe	pe	INTJ
admet-2603	129	18	.	.	PUNCT
admet-2603	130	1	in	in	ADP
admet-2603	130	2	the	the	DET
admet-2603	130	3	case	case	NOUN
admet-2603	130	4	of	of	ADP
admet-2603	130	5	a	a	DET
admet-2603	130	6	lipophilic	lipophilic	ADJ
admet-2603	130	7	weakly	weakly	ADJ
admet-2603	130	8	acidic	acidic	ADJ
admet-2603	130	9	drug	drug	NOUN
admet-2603	130	10	,	,	PUNCT
admet-2603	130	11	the	the	DET
admet-2603	130	12	membrane	membrane	NOUN
admet-2603	130	13	permeation	permeation	NOUN
admet-2603	130	14	of	of	ADP
admet-2603	130	15	unionized	unionized	ADJ
admet-2603	130	16	species	specie	NOUN
admet-2603	130	17	(	(	PUNCT
admet-2603	130	18	ha	ha	INTJ
admet-2603	130	19	)	)	PUNCT
admet-2603	130	20	removes	remove	VERB
admet-2603	130	21	proton	proton	NOUN
admet-2603	130	22	(	(	PUNCT
admet-2603	130	23	h+	h+	PROPN
admet-2603	130	24	)	)	PUNCT
admet-2603	130	25	from	from	ADP
admet-2603	130	26	the	the	DET
admet-2603	130	27	solution	solution	NOUN
admet-2603	130	28	on	on	ADP
admet-2603	130	29	the	the	DET
admet-2603	130	30	donor	donor	NOUN
admet-2603	130	31	side	side	NOUN
admet-2603	130	32	,	,	PUNCT
admet-2603	130	33	increases	increase	VERB
admet-2603	130	34	phms	phm	NOUN
admet-2603	130	35	,	,	PUNCT
admet-2603	130	36	and	and	CCONJ
admet-2603	130	37	subsequently	subsequently	ADV
admet-2603	130	38	decreases	decrease	VERB
admet-2603	130	39	f0	f0	PROPN
admet-2603	130	40	and	and	CCONJ
admet-2603	130	41	pe	pe	INTJ
admet-2603	130	42	.	.	PUNCT
admet-2603	131	1	because	because	SCONJ
admet-2603	131	2	the	the	DET
admet-2603	131	3	ph	ph	NOUN
admet-2603	131	4	neutralization	neutralization	NOUN
admet-2603	131	5	rate	rate	NOUN
admet-2603	131	6	of	of	ADP
admet-2603	131	7	bcb	bcb	PROPN
admet-2603	131	8	is	be	AUX
admet-2603	131	9	slower	slow	ADJ
admet-2603	131	10	than	than	ADP
admet-2603	131	11	that	that	PRON
admet-2603	131	12	of	of	ADP
admet-2603	131	13	ppb	ppb	NOUN
admet-2603	131	14	,	,	PUNCT
admet-2603	131	15	pe	pe	PROPN
admet-2603	131	16	in	in	ADP
admet-2603	131	17	bcb	bcb	PROPN
admet-2603	131	18	becomes	become	VERB
admet-2603	131	19	lower	low	ADJ
admet-2603	131	20	than	than	ADP
admet-2603	131	21	that	that	PRON
admet-2603	131	22	in	in	ADP
admet-2603	131	23	ppb	ppb	NOUN
admet-2603	131	24	.	.	PUNCT
admet-2603	132	1	the	the	DET
admet-2603	132	2	same	same	ADJ
admet-2603	132	3	discussion	discussion	NOUN
admet-2603	132	4	can	can	AUX
admet-2603	132	5	also	also	ADV
admet-2603	132	6	be	be	AUX
admet-2603	132	7	applied	apply	VERB
admet-2603	132	8	to	to	ADP
admet-2603	132	9	lipophilic	lipophilic	ADJ
admet-2603	132	10	weakly	weakly	ADJ
admet-2603	132	11	basic	basic	ADJ
admet-2603	132	12	drugs	drug	NOUN
admet-2603	132	13	.	.	PUNCT
admet-2603	133	1	i	i	PRON
admet-2603	133	2	ii	ii	VERB
admet-2603	133	3	a	a	DET
admet-2603	133	4	b	b	PROPN
admet-2603	133	5	figure	figure	NOUN
admet-2603	133	6	6	6	NUM
admet-2603	133	7	.	.	PUNCT
admet-2603	133	8	permeation	permeation	NOUN
admet-2603	133	9	of	of	ADP
admet-2603	133	10	drugs	drug	NOUN
admet-2603	133	11	as	as	ADP
admet-2603	133	12	an	an	DET
admet-2603	133	13	unionized	unionized	ADJ
admet-2603	133	14	form	form	NOUN
admet-2603	133	15	(	(	PUNCT
admet-2603	133	16	i	i	NOUN
admet-2603	133	17	)	)	PUNCT
admet-2603	133	18	or	or	CCONJ
admet-2603	133	19	an	an	DET
admet-2603	133	20	ion	ion	NOUN
admet-2603	133	21	-	-	PUNCT
admet-2603	133	22	pair	pair	NOUN
admet-2603	133	23	(	(	PUNCT
admet-2603	133	24	ii	ii	NOUN
admet-2603	133	25	)	)	PUNCT
admet-2603	133	26	across	across	ADP
admet-2603	133	27	the	the	DET
admet-2603	133	28	lipid	lipid	NOUN
admet-2603	133	29	membrane	membrane	NOUN
admet-2603	133	30	.	.	PUNCT
admet-2603	134	1	(	(	PUNCT
admet-2603	134	2	i	i	NOUN
admet-2603	134	3	-	-	PUNCT
admet-2603	134	4	a	a	NOUN
admet-2603	134	5	)	)	PUNCT
admet-2603	134	6	permeation	permeation	NOUN
admet-2603	134	7	of	of	ADP
admet-2603	134	8	unionized	unionized	ADJ
admet-2603	134	9	weakly	weakly	ADJ
admet-2603	134	10	acidic	acidic	ADJ
admet-2603	134	11	drug	drug	NOUN
admet-2603	134	12	molecules	molecule	NOUN
admet-2603	134	13	(	(	PUNCT
admet-2603	134	14	ha	ha	INTJ
admet-2603	134	15	)	)	PUNCT
admet-2603	134	16	removes	remove	VERB
admet-2603	134	17	h+	h+	X
admet-2603	134	18	and	and	CCONJ
admet-2603	134	19	increases	increase	VERB
admet-2603	134	20	ph	ph	NOUN
admet-2603	134	21	adjacent	adjacent	ADJ
admet-2603	134	22	to	to	ADP
admet-2603	134	23	the	the	DET
admet-2603	134	24	membrane	membrane	NOUN
admet-2603	134	25	surface	surface	NOUN
admet-2603	134	26	on	on	ADP
admet-2603	134	27	the	the	DET
admet-2603	134	28	donor	donor	NOUN
admet-2603	134	29	side	side	NOUN
admet-2603	134	30	(	(	PUNCT
admet-2603	134	31	phms	phm	NOUN
admet-2603	134	32	)	)	PUNCT
admet-2603	134	33	.	.	PUNCT
admet-2603	135	1	(	(	PUNCT
admet-2603	135	2	i	i	NOUN
admet-2603	135	3	-	-	PUNCT
admet-2603	135	4	b	b	NOUN
admet-2603	135	5	)	)	PUNCT
admet-2603	135	6	permeation	permeation	NOUN
admet-2603	135	7	of	of	ADP
admet-2603	135	8	unionized	unionized	ADJ
admet-2603	135	9	weakly	weakly	ADJ
admet-2603	135	10	basic	basic	ADJ
admet-2603	135	11	drug	drug	NOUN
admet-2603	135	12	molecules	molecule	NOUN
admet-2603	135	13	(	(	PUNCT
admet-2603	135	14	b	b	NOUN
admet-2603	135	15	)	)	PUNCT
admet-2603	135	16	increases	increase	NOUN
admet-2603	135	17	h+	h+	PUNCT
admet-2603	135	18	and	and	CCONJ
admet-2603	135	19	decreases	decrease	VERB
admet-2603	135	20	phms	phm	NOUN
admet-2603	135	21	.	.	PUNCT
admet-2603	136	1	(	(	PUNCT
admet-2603	136	2	ii	ii	NOUN
admet-2603	136	3	)	)	PUNCT
admet-2603	136	4	permeation	permeation	NOUN
admet-2603	136	5	of	of	ADP
admet-2603	136	6	ionized	ionized	ADJ
admet-2603	136	7	(	(	PUNCT
admet-2603	136	8	protonated	protonated	ADJ
admet-2603	136	9	)	)	PUNCT
admet-2603	136	10	weakly	weakly	ADJ
admet-2603	136	11	basic	basic	ADJ
admet-2603	136	12	drug	drug	NOUN
admet-2603	136	13	molecules	molecule	NOUN
admet-2603	136	14	removes	remove	VERB
admet-2603	136	15	h+	h+	PUNCT
admet-2603	136	16	and	and	CCONJ
admet-2603	136	17	increases	increase	VERB
admet-2603	136	18	phms	phm	NOUN
admet-2603	136	19	.	.	PUNCT
admet-2603	137	1	in	in	ADP
admet-2603	137	2	the	the	DET
admet-2603	137	3	case	case	NOUN
admet-2603	137	4	of	of	ADP
admet-2603	137	5	hydrophilic	hydrophilic	ADJ
admet-2603	137	6	weakly	weakly	ADJ
admet-2603	137	7	basic	basic	ADJ
admet-2603	137	8	drugs	drug	NOUN
admet-2603	137	9	(	(	PUNCT
admet-2603	137	10	metoprolol	metoprolol	NOUN
admet-2603	137	11	and	and	CCONJ
admet-2603	137	12	procainamide	procainamide	NOUN
admet-2603	137	13	)	)	PUNCT
admet-2603	137	14	,	,	PUNCT
admet-2603	137	15	the	the	DET
admet-2603	137	16	pe	pe	PROPN
admet-2603	137	17	values	value	NOUN
admet-2603	137	18	in	in	ADP
admet-2603	137	19	bcb	bcb	PROPN
admet-2603	137	20	and	and	CCONJ
admet-2603	137	21	ppb	ppb	NOUN
admet-2603	137	22	were	be	AUX
admet-2603	137	23	similar	similar	ADJ
admet-2603	137	24	.	.	PUNCT
admet-2603	138	1	the	the	DET
admet-2603	138	2	pe	pe	PROPN
admet-2603	138	3	values	value	NOUN
admet-2603	138	4	of	of	ADP
admet-2603	138	5	these	these	DET
admet-2603	138	6	drugs	drug	NOUN
admet-2603	138	7	were	be	AUX
admet-2603	138	8	higher	high	ADJ
admet-2603	138	9	than	than	SCONJ
admet-2603	138	10	expected	expect	VERB
admet-2603	138	11	from	from	ADP
admet-2603	138	12	their	their	PRON
admet-2603	138	13	low	low	ADJ
admet-2603	138	14	log	log	NOUN
admet-2603	138	15	doct	doct	NOUN
admet-2603	138	16	,	,	PUNCT
admet-2603	138	17	ph	ph	VERB
admet-2603	138	18	6.5	6.5	NUM
admet-2603	138	19	values	value	NOUN
admet-2603	138	20	(	(	PUNCT
admet-2603	138	21	<	<	X
admet-2603	138	22	-1	-1	X
admet-2603	138	23	)	)	PUNCT
admet-2603	138	24	,	,	PUNCT
admet-2603	138	25	suggesting	suggest	VERB
admet-2603	138	26	that	that	SCONJ
admet-2603	138	27	their	their	PRON
admet-2603	138	28	membrane	membrane	NOUN
admet-2603	138	29	permeation	permeation	NOUN
admet-2603	138	30	can	can	AUX
admet-2603	138	31	not	not	PART
admet-2603	138	32	be	be	AUX
admet-2603	138	33	elucidated	elucidate	VERB
admet-2603	138	34	solely	solely	ADV
admet-2603	138	35	by	by	ADP
admet-2603	138	36	the	the	DET
admet-2603	138	37	ph	ph	ADJ
admet-2603	138	38	partition	partition	NOUN
admet-2603	138	39	theory	theory	NOUN
admet-2603	138	40	.	.	PUNCT
admet-2603	139	1	previously	previously	ADV
admet-2603	139	2	,	,	PUNCT
admet-2603	139	3	the	the	DET
admet-2603	139	4	passive	passive	ADJ
admet-2603	139	5	membrane	membrane	NOUN
admet-2603	139	6	permeation	permeation	NOUN
admet-2603	139	7	of	of	ADP
admet-2603	139	8	ionized	ionized	ADJ
admet-2603	139	9	hydrophilic	hydrophilic	ADJ
admet-2603	139	10	weakly	weakly	ADJ
admet-2603	139	11	basic	basic	ADJ
admet-2603	139	12	drug	drug	NOUN
admet-2603	139	13	molecules	molecule	NOUN
admet-2603	139	14	has	have	AUX
admet-2603	139	15	been	be	AUX
admet-2603	139	16	reported	report	VERB
admet-2603	139	17	to	to	PART
admet-2603	139	18	occur	occur	VERB
admet-2603	139	19	via	via	ADP
admet-2603	139	20	ion	ion	NOUN
admet-2603	139	21	-	-	PUNCT
admet-2603	139	22	pair	pair	NOUN
admet-2603	139	23	transport	transport	NOUN
admet-2603	139	24	with	with	ADP
admet-2603	139	25	an	an	DET
admet-2603	139	26	anionic	anionic	ADJ
admet-2603	139	27	phospholipid	phospholipid	NOUN
admet-2603	139	28	in	in	ADP
admet-2603	139	29	the	the	DET
admet-2603	139	30	membrane	membrane	NOUN
admet-2603	139	31	,	,	PUNCT
admet-2603	139	32	such	such	ADJ
admet-2603	139	33	as	as	ADP
admet-2603	139	34	phosphatidylinositol	phosphatidylinositol	NOUN
admet-2603	139	35	(	(	PUNCT
admet-2603	139	36	figure	figure	NOUN
admet-2603	139	37	6ii	6ii	NOUN
admet-2603	139	38	)	)	PUNCT
admet-2603	140	1	[	[	X
admet-2603	140	2	32,33	32,33	NUM
admet-2603	140	3	]	]	PUNCT
admet-2603	140	4	.	.	PUNCT
admet-2603	141	1	in	in	ADP
admet-2603	141	2	this	this	DET
admet-2603	141	3	case	case	NOUN
admet-2603	141	4	,	,	PUNCT
admet-2603	141	5	the	the	DET
admet-2603	141	6	pe	pe	PROPN
admet-2603	141	7	values	value	NOUN
admet-2603	141	8	were	be	AUX
admet-2603	141	9	reported	report	VERB
admet-2603	141	10	to	to	PART
admet-2603	141	11	be	be	AUX
admet-2603	141	12	less	less	ADV
admet-2603	141	13	ph	ph	ADJ
admet-2603	141	14	sensitive	sensitive	ADJ
admet-2603	141	15	and	and	CCONJ
admet-2603	141	16	do	do	AUX
admet-2603	141	17	not	not	PART
admet-2603	141	18	follow	follow	VERB
admet-2603	141	19	the	the	DET
admet-2603	141	20	ph	ph	ADJ
admet-2603	141	21	partitioning	partitioning	NOUN
admet-2603	141	22	theory	theory	NOUN
admet-2603	141	23	in	in	ADP
admet-2603	141	24	a	a	DET
admet-2603	141	25	ph	ph	ADJ
admet-2603	141	26	range	range	NOUN
admet-2603	141	27	where	where	SCONJ
admet-2603	141	28	ion	ion	NOUN
admet-2603	141	29	-	-	PUNCT
admet-2603	141	30	pair	pair	NOUN
admet-2603	141	31	transport	transport	NOUN
admet-2603	141	32	becomes	become	VERB
admet-2603	141	33	predominant	predominant	ADJ
admet-2603	141	34	[	[	X
admet-2603	141	35	32	32	NUM
admet-2603	141	36	]	]	PUNCT
admet-2603	141	37	.	.	PUNCT
admet-2603	142	1	theoretically	theoretically	ADV
admet-2603	142	2	,	,	PUNCT
admet-2603	142	3	ion	ion	NOUN
admet-2603	142	4	-	-	PUNCT
admet-2603	142	5	pair	pair	NOUN
admet-2603	142	6	transport	transport	NOUN
admet-2603	142	7	would	would	AUX
admet-2603	142	8	depend	depend	VERB
admet-2603	142	9	on	on	ADP
admet-2603	142	10	the	the	DET
admet-2603	142	11	fraction	fraction	NOUN
admet-2603	142	12	of	of	ADP
admet-2603	142	13	cationic	cationic	ADJ
admet-2603	142	14	species	specie	NOUN
admet-2603	142	15	(	(	PUNCT
admet-2603	142	16	f+	f+	PROPN
admet-2603	142	17	)	)	PUNCT
admet-2603	142	18	.	.	PUNCT
admet-2603	143	1	the	the	DET
admet-2603	143	2	permeation	permeation	NOUN
admet-2603	143	3	of	of	ADP
admet-2603	143	4	the	the	DET
admet-2603	143	5	protonated	protonate	VERB
admet-2603	143	6	species	specie	NOUN
admet-2603	143	7	of	of	ADP
admet-2603	143	8	a	a	DET
admet-2603	143	9	weakly	weakly	ADJ
admet-2603	143	10	basic	basic	ADJ
admet-2603	143	11	drug	drug	NOUN
admet-2603	143	12	(	(	PUNCT
admet-2603	143	13	bh+	bh+	NOUN
admet-2603	143	14	)	)	PUNCT
admet-2603	143	15	as	as	ADP
admet-2603	143	16	an	an	DET
admet-2603	143	17	ion	ion	NOUN
admet-2603	143	18	-	-	PUNCT
admet-2603	143	19	pair	pair	NOUN
admet-2603	143	20	with	with	ADP
admet-2603	143	21	an	an	DET
admet-2603	143	22	anionic	anionic	ADJ
admet-2603	143	23	phospholipid	phospholipid	NOUN
admet-2603	143	24	may	may	AUX
admet-2603	143	25	increase	increase	VERB
admet-2603	143	26	the	the	DET
admet-2603	143	27	phms	phm	NOUN
admet-2603	143	28	value	value	NOUN
admet-2603	143	29	.	.	PUNCT
admet-2603	144	1	however	however	ADV
admet-2603	144	2	,	,	PUNCT
admet-2603	144	3	the	the	DET
admet-2603	144	4	f+	f+	ADJ
admet-2603	144	5	values	value	NOUN
admet-2603	144	6	of	of	ADP
admet-2603	144	7	these	these	DET
admet-2603	144	8	drugs	drug	NOUN
admet-2603	144	9	are	be	AUX
admet-2603	144	10	little	little	ADJ
admet-2603	144	11	affected	affect	VERB
admet-2603	144	12	by	by	ADP
admet-2603	144	13	a	a	DET
admet-2603	144	14	difference	difference	NOUN
admet-2603	144	15	in	in	ADP
admet-2603	144	16	phms	phm	NOUN
admet-2603	144	17	(	(	PUNCT
admet-2603	144	18	f+	f+	X
admet-2603	144	19	>	>	X
admet-2603	144	20	0.99	0.99	NUM
admet-2603	144	21	)	)	PUNCT
admet-2603	144	22	,	,	PUNCT
admet-2603	144	23	resulting	result	VERB
admet-2603	144	24	in	in	ADP
admet-2603	144	25	similar	similar	ADJ
admet-2603	144	26	pe	pe	PROPN
admet-2603	144	27	values	value	NOUN
admet-2603	144	28	between	between	ADP
admet-2603	144	29	bcb	bcb	PROPN
admet-2603	144	30	and	and	CCONJ
admet-2603	144	31	ppb	ppb	NOUN
admet-2603	144	32	.	.	PUNCT
admet-2603	145	1	the	the	DET
admet-2603	145	2	theoretical	theoretical	ADJ
admet-2603	145	3	calculation	calculation	NOUN
admet-2603	145	4	of	of	ADP
admet-2603	145	5	phms	phm	NOUN
admet-2603	145	6	is	be	AUX
admet-2603	145	7	of	of	ADP
admet-2603	145	8	great	great	ADJ
admet-2603	145	9	interest	interest	NOUN
admet-2603	145	10	and	and	CCONJ
admet-2603	145	11	is	be	AUX
admet-2603	145	12	currently	currently	ADV
admet-2603	145	13	under	under	ADP
admet-2603	145	14	investigation	investigation	NOUN
admet-2603	145	15	.	.	PUNCT
admet-2603	146	1	at	at	ADP
admet-2603	146	2	this	this	DET
admet-2603	146	3	moment	moment	NOUN
admet-2603	146	4	,	,	PUNCT
admet-2603	146	5	it	it	PRON
admet-2603	146	6	is	be	AUX
admet-2603	146	7	unknown	unknown	ADJ
admet-2603	146	8	whether	whether	SCONJ
admet-2603	146	9	the	the	DET
admet-2603	146	10	result	result	NOUN
admet-2603	146	11	of	of	ADP
admet-2603	146	12	this	this	DET
admet-2603	146	13	study	study	NOUN
admet-2603	146	14	in	in	ADP
admet-2603	146	15	the	the	DET
admet-2603	146	16	pampa	pampa	NOUN
admet-2603	146	17	membrane	membrane	NOUN
admet-2603	146	18	would	would	AUX
admet-2603	146	19	be	be	AUX
admet-2603	146	20	relevant	relevant	ADJ
admet-2603	146	21	to	to	ADP
admet-2603	146	22	in	in	ADP
admet-2603	146	23	vitro	vitro	X
admet-2603	146	24	cellular	cellular	ADJ
admet-2603	146	25	models	model	NOUN
admet-2603	146	26	and/or	and/or	CCONJ
admet-2603	146	27	in	in	ADP
admet-2603	146	28	vivo	vivo	NOUN
admet-2603	146	29	.	.	PUNCT
admet-2603	147	1	the	the	DET
admet-2603	147	2	microclimate	microclimate	NOUN
admet-2603	147	3	ph	ph	NOUN
admet-2603	147	4	near	near	ADP
admet-2603	147	5	the	the	DET
admet-2603	147	6	epithelial	epithelial	ADJ
admet-2603	147	7	membrane	membrane	NOUN
admet-2603	147	8	is	be	AUX
admet-2603	147	9	well	well	ADV
admet-2603	147	10	controlled	control	VERB
admet-2603	147	11	in	in	ADP
admet-2603	147	12	vivo	vivo	NOUN
admet-2603	147	13	[	[	X
admet-2603	147	14	34	34	NUM
admet-2603	147	15	]	]	PUNCT
admet-2603	147	16	.	.	PUNCT
admet-2603	148	1	further	further	ADJ
admet-2603	148	2	investigation	investigation	NOUN
admet-2603	148	3	is	be	AUX
admet-2603	148	4	required	require	VERB
admet-2603	148	5	to	to	PART
admet-2603	148	6	clarify	clarify	VERB
admet-2603	148	7	this	this	DET
admet-2603	148	8	point	point	NOUN
admet-2603	148	9	.	.	PUNCT
admet-2603	149	1	in	in	ADP
admet-2603	149	2			PROPN
admet-2603	149	3	calculation	calculation	NOUN
admet-2603	149	4	,	,	PUNCT
admet-2603	149	5	when	when	SCONJ
admet-2603	149	6	the	the	DET
admet-2603	149	7	operational	operational	ADJ
admet-2603	149	8	electrode	electrode	NOUN
admet-2603	149	9	ph	ph	NOUN
admet-2603	149	10	was	be	AUX
admet-2603	149	11	converted	convert	VERB
admet-2603	149	12	to	to	ADP
admet-2603	149	13	[	[	X
admet-2603	149	14	h+	h+	X
admet-2603	149	15	]	]	X
admet-2603	149	16	(	(	PUNCT
admet-2603	149	17	i	i	NOUN
admet-2603	149	18	=	=	PUNCT
admet-2603	149	19	0.15	0.15	NUM
admet-2603	149	20	m	m	VERB
admet-2603	149	21	)	)	PUNCT
admet-2603	149	22	by	by	ADP
admet-2603	149	23	the	the	DET
admet-2603	149	24	avdeef−bucher	avdeef−bucher	ADJ
admet-2603	149	25	four	four	NUM
admet-2603	149	26	-	-	PUNCT
admet-2603	149	27	parameter	parameter	NOUN
admet-2603	149	28	equation	equation	NOUN
admet-2603	149	29	[	[	X
admet-2603	149	30	20	20	NUM
admet-2603	149	31	]	]	PUNCT
admet-2603	149	32	and	and	CCONJ
admet-2603	149	33	all	all	DET
admet-2603	149	34	pka	pka	PROPN
admet-2603	149	35	values	value	NOUN
admet-2603	149	36	(	(	PUNCT
admet-2603	149	37	bcb	bcb	PROPN
admet-2603	149	38	:	:	PUNCT
admet-2603	149	39	6.05	6.05	NUM
admet-2603	149	40	;	;	PUNCT
admet-2603	149	41	9.79	9.79	NUM
admet-2603	149	42	,	,	PUNCT
admet-2603	149	43	ppb	ppb	NOUN
admet-2603	149	44	:	:	PUNCT
admet-2603	149	45	1.94	1.94	NUM
admet-2603	149	46	;	;	PUNCT
admet-2603	149	47	6.69	6.69	NUM
admet-2603	149	48	;	;	PUNCT
admet-2603	149	49	11.61	11.61	NUM
admet-2603	149	50	(	(	PUNCT
admet-2603	149	51	i	i	NOUN
admet-2603	149	52	=	=	PUNCT
admet-2603	149	53	0.15	0.15	NUM
admet-2603	149	54	m	m	PROPN
admet-2603	149	55	,	,	PUNCT
admet-2603	149	56	37	37	NUM
admet-2603	149	57	°	°	NOUN
admet-2603	149	58	c	c	NOUN
admet-2603	149	59	)	)	PUNCT
admet-2603	149	60	)	)	PUNCT
admet-2603	150	1	[	[	X
admet-2603	150	2	20	20	NUM
admet-2603	150	3	]	]	PUNCT
admet-2603	150	4	are	be	AUX
admet-2603	150	5	used	use	VERB
admet-2603	150	6	for	for	ADP
admet-2603	150	7	the	the	DET
admet-2603	150	8	3	3	NUM
admet-2603	150	9	pka	pka	PROPN
admet-2603	150	10	van	van	PROPN
admet-2603	150	11	slyke	slyke	PROPN
admet-2603	150	12	equation	equation	NOUN
admet-2603	150	13	[	[	X
admet-2603	150	14	31	31	NUM
admet-2603	150	15	]	]	PUNCT
admet-2603	150	16	,	,	PUNCT
admet-2603	150	17	the	the	DET
admet-2603	150	18			PROPN
admet-2603	150	19	values	value	NOUN
admet-2603	150	20	were	be	AUX
admet-2603	150	21	calculated	calculate	VERB
admet-2603	150	22	to	to	PART
admet-2603	150	23	be	be	AUX
admet-2603	150	24	4.9	4.9	NUM
admet-2603	150	25	and	and	CCONJ
admet-2603	150	26	4.1	4.1	NUM
admet-2603	150	27	for	for	ADP
admet-2603	150	28	bcb	bcb	PROPN
admet-2603	150	29	(	(	PUNCT
admet-2603	150	30	10	10	NUM
admet-2603	150	31	mm	mm	NOUN
admet-2603	150	32	)	)	PUNCT
admet-2603	150	33	and	and	CCONJ
admet-2603	150	34	ppb	ppb	NOUN
admet-2603	150	35	(	(	PUNCT
admet-2603	150	36	8.0	8.0	NUM
admet-2603	150	37	mm	mm	NOUN
admet-2603	150	38	)	)	PUNCT
admet-2603	150	39	,	,	PUNCT
admet-2603	150	40	respectively	respectively	ADV
admet-2603	150	41	.	.	PUNCT
admet-2603	151	1	previously	previously	ADV
admet-2603	151	2	,	,	PUNCT
admet-2603	151	3	the	the	DET
admet-2603	151	4			PROPN
admet-2603	151	5	values	value	NOUN
admet-2603	151	6	of	of	ADP
admet-2603	151	7	bcb	bcb	PROPN
admet-2603	151	8	10	10	NUM
admet-2603	151	9	mm	mm	NOUN
admet-2603	151	10	and	and	CCONJ
admet-2603	151	11	ppb	ppb	VERB
admet-2603	151	12	8	8	NUM
admet-2603	151	13	mm	mm	NOUN
admet-2603	151	14	at	at	ADP
admet-2603	151	15	ph	ph	PROPN
admet-2603	151	16	6.5	6.5	NUM
admet-2603	151	17	were	be	AUX
admet-2603	151	18	experimentally	experimentally	ADV
admet-2603	151	19	determined	determine	VERB
admet-2603	151	20	to	to	PART
admet-2603	151	21	be	be	AUX
admet-2603	151	22	4.6	4.6	NUM
admet-2603	151	23	and	and	CCONJ
admet-2603	151	24	4.5	4.5	NUM
admet-2603	151	25	mmol	mmol	NOUN
admet-2603	151	26	l-1	l-1	NOUN
admet-2603	151	27	ph-1	ph-1	PROPN
admet-2603	151	28	,	,	PUNCT
admet-2603	151	29	respectively	respectively	ADV
admet-2603	151	30	[	[	X
admet-2603	151	31	19	19	NUM
admet-2603	151	32	]	]	PUNCT
admet-2603	151	33	.	.	PUNCT
admet-2603	152	1	the	the	PRON
admet-2603	152	2	higher	high	ADJ
admet-2603	152	3	the	the	DET
admet-2603	152	4			PROPN
admet-2603	152	5	value	value	NOUN
admet-2603	152	6	,	,	PUNCT
admet-2603	152	7	the	the	PRON
admet-2603	152	8	lower	low	ADJ
admet-2603	152	9	the	the	DET
admet-2603	152	10	decrease	decrease	NOUN
admet-2603	152	11	in	in	ADP
admet-2603	152	12	drug	drug	NOUN
admet-2603	152	13	permeation	permeation	NOUN
admet-2603	152	14	due	due	ADP
admet-2603	152	15	to	to	ADP
admet-2603	152	16	phms	phm	NOUN
admet-2603	152	17	change	change	NOUN
admet-2603	152	18	,	,	PUNCT
admet-2603	152	19	as	as	SCONJ
admet-2603	152	20	is	be	AUX
admet-2603	152	21	the	the	DET
admet-2603	152	22	case	case	NOUN
admet-2603	152	23	for	for	ADP
admet-2603	152	24	phps	phps	PROPN
admet-2603	152	25	[	[	X
admet-2603	152	26	35	35	NUM
admet-2603	152	27	-	-	SYM
admet-2603	152	28	37	37	NUM
admet-2603	152	29	]	]	PUNCT
admet-2603	152	30	.	.	PUNCT
admet-2603	153	1	the	the	DET
admet-2603	153	2	effect	effect	NOUN
admet-2603	153	3	of	of	ADP
admet-2603	153	4	this	this	DET
admet-2603	153	5	difference	difference	NOUN
admet-2603	153	6	on	on	ADP
admet-2603	153	7	pe	pe	PROPN
admet-2603	153	8	may	may	AUX
admet-2603	153	9	be	be	AUX
admet-2603	153	10	small	small	ADJ
admet-2603	153	11	but	but	CCONJ
admet-2603	153	12	could	could	AUX
admet-2603	153	13	be	be	AUX
admet-2603	153	14	a	a	DET
admet-2603	153	15	possible	possible	ADJ
admet-2603	153	16	factor	factor	NOUN
admet-2603	153	17	in	in	ADP
admet-2603	153	18	addition	addition	NOUN
admet-2603	153	19	to	to	ADP
admet-2603	153	20	the	the	DET
admet-2603	153	21	slow	slow	ADJ
admet-2603	153	22	rate	rate	NOUN
admet-2603	153	23	of	of	ADP
admet-2603	153	24	carbon	carbon	NOUN
admet-2603	153	25	dioxide	dioxide	NOUN
admet-2603	153	26	hydration	hydration	NOUN
admet-2603	153	27	.	.	PUNCT
admet-2603	154	1	admet	admet	PROPN
admet-2603	154	2	&	&	CCONJ
admet-2603	154	3	dmpk	dmpk	PROPN
admet-2603	154	4	13(1	13(1	NUM
admet-2603	154	5	)	)	PUNCT
admet-2603	154	6	(	(	PUNCT
admet-2603	154	7	2025	2025	NUM
admet-2603	154	8	)	)	PUNCT
admet-2603	154	9	2603	2603	NUM
admet-2603	154	10	effect	effect	NOUN
admet-2603	154	11	of	of	ADP
admet-2603	154	12	bicarbonate	bicarbonate	NOUN
admet-2603	154	13	buffer	buffer	NOUN
admet-2603	154	14	on	on	ADP
admet-2603	154	15	artificial	artificial	ADJ
admet-2603	154	16	membrane	membrane	NOUN
admet-2603	154	17	permeation	permeation	NOUN
admet-2603	154	18	of	of	ADP
admet-2603	154	19	drugs	drug	NOUN
admet-2603	154	20	doi	doi	PROPN
admet-2603	154	21	:	:	PUNCT
admet-2603	154	22	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	154	23	7	7	NUM
admet-2603	154	24	conclusions	conclusion	NOUN
admet-2603	154	25	in	in	ADP
admet-2603	154	26	conclusion	conclusion	NOUN
admet-2603	154	27	,	,	PUNCT
admet-2603	154	28	the	the	DET
admet-2603	154	29	floating	float	VERB
admet-2603	154	30	lid	lid	NOUN
admet-2603	154	31	method	method	NOUN
admet-2603	154	32	enabled	enable	VERB
admet-2603	154	33	the	the	DET
admet-2603	154	34	use	use	NOUN
admet-2603	154	35	of	of	ADP
admet-2603	154	36	bcb	bcb	PROPN
admet-2603	154	37	in	in	ADP
admet-2603	154	38	μflux	μflux	NOUN
admet-2603	154	39	.	.	PUNCT
admet-2603	155	1	it	it	PRON
admet-2603	155	2	was	be	AUX
admet-2603	155	3	found	find	VERB
admet-2603	155	4	for	for	ADP
admet-2603	155	5	the	the	DET
admet-2603	155	6	first	first	ADJ
admet-2603	155	7	time	time	NOUN
admet-2603	155	8	that	that	SCONJ
admet-2603	155	9	the	the	DET
admet-2603	155	10	membrane	membrane	NOUN
admet-2603	155	11	permeation	permeation	NOUN
admet-2603	155	12	of	of	ADP
admet-2603	155	13	lipophilic	lipophilic	ADJ
admet-2603	155	14	weakly	weakly	ADJ
admet-2603	155	15	acidic	acidic	ADJ
admet-2603	155	16	and	and	CCONJ
admet-2603	155	17	basic	basic	ADJ
admet-2603	155	18	drugs	drug	NOUN
admet-2603	155	19	can	can	AUX
admet-2603	155	20	be	be	AUX
admet-2603	155	21	slower	slow	ADJ
admet-2603	155	22	in	in	ADP
admet-2603	155	23	bcb	bcb	PROPN
admet-2603	155	24	than	than	ADP
admet-2603	155	25	in	in	ADP
admet-2603	155	26	ppb	ppb	NOUN
admet-2603	155	27	.	.	PUNCT
admet-2603	156	1	it	it	PRON
admet-2603	156	2	was	be	AUX
admet-2603	156	3	suggested	suggest	VERB
admet-2603	156	4	that	that	SCONJ
admet-2603	156	5	this	this	DET
admet-2603	156	6	effect	effect	NOUN
admet-2603	156	7	was	be	AUX
admet-2603	156	8	attributed	attribute	VERB
admet-2603	156	9	to	to	ADP
admet-2603	156	10	the	the	DET
admet-2603	156	11	slow	slow	ADJ
admet-2603	156	12	ph	ph	NOUN
admet-2603	156	13	neutralization	neutralization	NOUN
admet-2603	156	14	rate	rate	NOUN
admet-2603	156	15	of	of	ADP
admet-2603	156	16	bcb	bcb	PROPN
admet-2603	156	17	at	at	ADP
admet-2603	156	18	the	the	DET
admet-2603	156	19	membrane	membrane	NOUN
admet-2603	156	20	surface	surface	NOUN
admet-2603	156	21	.	.	PUNCT
admet-2603	157	1	funding	funding	NOUN
admet-2603	157	2	:	:	PUNCT
admet-2603	157	3	no	no	DET
admet-2603	157	4	funding	funding	NOUN
admet-2603	157	5	support	support	NOUN
admet-2603	157	6	conflict	conflict	NOUN
admet-2603	157	7	of	of	ADP
admet-2603	157	8	interest	interest	NOUN
admet-2603	157	9	:	:	PUNCT
admet-2603	157	10	the	the	DET
admet-2603	157	11	author(s	author(s	PROPN
admet-2603	157	12	)	)	PUNCT
admet-2603	157	13	declare(s	declare(s	PROPN
admet-2603	157	14	)	)	PUNCT
admet-2603	157	15	that	that	SCONJ
admet-2603	157	16	they	they	PRON
admet-2603	157	17	have	have	VERB
admet-2603	157	18	no	no	DET
admet-2603	157	19	conflicts	conflict	NOUN
admet-2603	157	20	of	of	ADP
admet-2603	157	21	interest	interest	NOUN
admet-2603	157	22	to	to	PART
admet-2603	157	23	disclose	disclose	VERB
admet-2603	157	24	.	.	PUNCT
admet-2603	158	1	author	author	NOUN
admet-2603	158	2	contributions	contribution	NOUN
admet-2603	158	3	:	:	PUNCT
admet-2603	158	4	material	material	NOUN
admet-2603	158	5	preparation	preparation	NOUN
admet-2603	158	6	,	,	PUNCT
admet-2603	158	7	data	data	NOUN
admet-2603	158	8	collection	collection	NOUN
admet-2603	158	9	,	,	PUNCT
admet-2603	158	10	and	and	CCONJ
admet-2603	158	11	analysis	analysis	NOUN
admet-2603	158	12	were	be	AUX
admet-2603	158	13	performed	perform	VERB
admet-2603	158	14	by	by	ADP
admet-2603	158	15	shiori	shiori	PROPN
admet-2603	158	16	ishida	ishida	PROPN
admet-2603	158	17	.	.	PUNCT
admet-2603	159	1	samuel	samuel	PROPN
admet-2603	159	2	lee	lee	PROPN
admet-2603	159	3	,	,	PUNCT
admet-2603	159	4	balint	balint	PROPN
admet-2603	159	5	sinko	sinko	PROPN
admet-2603	159	6	,	,	PUNCT
admet-2603	159	7	and	and	CCONJ
admet-2603	159	8	karl	karl	PROPN
admet-2603	159	9	box	box	PROPN
admet-2603	159	10	participated	participate	VERB
admet-2603	159	11	in	in	ADP
admet-2603	159	12	data	data	NOUN
admet-2603	159	13	analysis	analysis	NOUN
admet-2603	159	14	and	and	CCONJ
admet-2603	159	15	manuscript	manuscript	NOUN
admet-2603	159	16	writing	writing	NOUN
admet-2603	159	17	.	.	PUNCT
admet-2603	160	1	kiyohiko	kiyohiko	PROPN
admet-2603	160	2	sugano	sugano	PROPN
admet-2603	160	3	supervised	supervise	VERB
admet-2603	160	4	all	all	DET
admet-2603	160	5	phases	phase	NOUN
admet-2603	160	6	of	of	ADP
admet-2603	160	7	the	the	DET
admet-2603	160	8	study	study	NOUN
admet-2603	160	9	,	,	PUNCT
admet-2603	160	10	including	include	VERB
admet-2603	160	11	the	the	DET
admet-2603	160	12	manuscript	manuscript	NOUN
admet-2603	160	13	writing	writing	NOUN
admet-2603	160	14	.	.	PUNCT
admet-2603	161	1	all	all	DET
admet-2603	161	2	authors	author	NOUN
admet-2603	161	3	read	read	VERB
admet-2603	161	4	and	and	CCONJ
admet-2603	161	5	approved	approve	VERB
admet-2603	161	6	the	the	DET
admet-2603	161	7	final	final	ADJ
admet-2603	161	8	manuscript	manuscript	NOUN
admet-2603	161	9	.	.	PUNCT
admet-2603	162	1	data	datum	NOUN
admet-2603	162	2	availability	availability	NOUN
admet-2603	162	3	:	:	PUNCT
admet-2603	162	4	the	the	DET
admet-2603	162	5	datasets	dataset	NOUN
admet-2603	162	6	generated	generate	VERB
admet-2603	162	7	during	during	ADP
admet-2603	162	8	and/or	and/or	CCONJ
admet-2603	162	9	analyzed	analyze	VERB
admet-2603	162	10	during	during	ADP
admet-2603	162	11	the	the	DET
admet-2603	162	12	current	current	ADJ
admet-2603	162	13	study	study	NOUN
admet-2603	162	14	are	be	AUX
admet-2603	162	15	available	available	ADJ
admet-2603	162	16	from	from	ADP
admet-2603	162	17	the	the	DET
admet-2603	162	18	corresponding	corresponding	ADJ
admet-2603	162	19	author	author	NOUN
admet-2603	162	20	on	on	ADP
admet-2603	162	21	request	request	NOUN
admet-2603	162	22	.	.	PUNCT
admet-2603	163	1	references	reference	NOUN
admet-2603	163	2	[	[	X
admet-2603	163	3	1	1	X
admet-2603	163	4	]	]	X
admet-2603	163	5	d.m	d.m	PROPN
admet-2603	163	6	.	.	PROPN
admet-2603	163	7	mudie	mudie	PROPN
admet-2603	163	8	,	,	PUNCT
admet-2603	163	9	g.l	g.l	PROPN
admet-2603	163	10	.	.	PROPN
admet-2603	163	11	amidon	amidon	PROPN
admet-2603	163	12	,	,	PUNCT
admet-2603	163	13	g.e	g.e	PROPN
admet-2603	163	14	.	.	PROPN
admet-2603	163	15	amidon	amidon	PROPN
admet-2603	163	16	.	.	PUNCT
admet-2603	164	1	physiological	physiological	ADJ
admet-2603	164	2	parameters	parameter	NOUN
admet-2603	164	3	for	for	ADP
admet-2603	164	4	oral	oral	ADJ
admet-2603	164	5	delivery	delivery	NOUN
admet-2603	164	6	and	and	CCONJ
admet-2603	164	7	in	in	ADP
admet-2603	164	8	vitro	vitro	X
admet-2603	164	9	testing	testing	NOUN
admet-2603	164	10	.	.	PUNCT
admet-2603	165	1	molecular	molecular	ADJ
admet-2603	165	2	pharmaceutics	pharmaceutic	NOUN
admet-2603	165	3	7	7	NUM
admet-2603	165	4	(	(	PUNCT
admet-2603	165	5	2010	2010	NUM
admet-2603	165	6	)	)	PUNCT
admet-2603	165	7	1388	1388	NUM
admet-2603	165	8	-	-	SYM
admet-2603	165	9	1405	1405	NUM
admet-2603	165	10	.	.	PUNCT
admet-2603	166	1	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	PUNCT
admet-2603	167	1	[	[	X
admet-2603	167	2	2	2	X
admet-2603	167	3	]	]	PUNCT
admet-2603	167	4	c.	c.	PROPN
admet-2603	167	5	litou	litou	PROPN
admet-2603	167	6	,	,	PUNCT
admet-2603	167	7	d.	d.	PROPN
admet-2603	167	8	psachoulias	psachoulias	PROPN
admet-2603	167	9	,	,	PUNCT
admet-2603	167	10	m.	m.	NOUN
admet-2603	167	11	vertzoni	vertzoni	PROPN
admet-2603	167	12	,	,	PUNCT
admet-2603	167	13	j.	j.	PROPN
admet-2603	167	14	dressman	dressman	PROPN
admet-2603	167	15	,	,	PUNCT
admet-2603	167	16	c.	c.	PROPN
admet-2603	167	17	reppas	reppas	PROPN
admet-2603	167	18	.	.	PUNCT
admet-2603	168	1	measuring	measure	VERB
admet-2603	168	2	ph	ph	NOUN
admet-2603	168	3	and	and	CCONJ
admet-2603	168	4	buffer	buffer	NOUN
admet-2603	168	5	capacity	capacity	NOUN
admet-2603	168	6	in	in	ADP
admet-2603	168	7	fluids	fluid	NOUN
admet-2603	168	8	aspirated	aspirate	VERB
admet-2603	168	9	from	from	ADP
admet-2603	168	10	the	the	DET
admet-2603	168	11	fasted	fast	VERB
admet-2603	168	12	upper	upper	ADJ
admet-2603	168	13	gastrointestinal	gastrointestinal	ADJ
admet-2603	168	14	tract	tract	NOUN
admet-2603	168	15	of	of	ADP
admet-2603	168	16	healthy	healthy	ADJ
admet-2603	168	17	adults	adult	NOUN
admet-2603	168	18	.	.	PUNCT
admet-2603	169	1	pharmaceutical	pharmaceutical	NOUN
admet-2603	169	2	research	research	NOUN
admet-2603	169	3	37	37	NUM
admet-2603	169	4	(	(	PUNCT
admet-2603	169	5	2020	2020	NUM
admet-2603	169	6	)	)	PUNCT
admet-2603	169	7	42	42	NUM
admet-2603	169	8	.	.	PUNCT
admet-2603	170	1	https://doi.org/10.1007/s11095-019-2731-3	https://doi.org/10.1007/s11095-019-2731-3	PROPN
admet-2603	170	2	.	.	PUNCT
admet-2603	171	1	[	[	X
admet-2603	171	2	3	3	NUM
admet-2603	171	3	]	]	X
admet-2603	171	4	d.a	d.a	PROPN
admet-2603	171	5	.	.	PROPN
admet-2603	171	6	silva	silva	PROPN
admet-2603	171	7	,	,	PUNCT
admet-2603	171	8	j.	j.	PROPN
admet-2603	171	9	al	al	PROPN
admet-2603	171	10	-	-	PUNCT
admet-2603	171	11	gousous	gousous	ADJ
admet-2603	171	12	,	,	PUNCT
admet-2603	171	13	n.m	n.m	PROPN
admet-2603	171	14	.	.	PROPN
admet-2603	171	15	davies	davy	NOUN
admet-2603	171	16	,	,	PUNCT
admet-2603	171	17	n.b	n.b	PROPN
admet-2603	171	18	.	.	PROPN
admet-2603	171	19	chacra	chacra	PROPN
admet-2603	171	20	,	,	PUNCT
admet-2603	171	21	g.k	g.k	PROPN
admet-2603	171	22	.	.	PROPN
admet-2603	171	23	webster	webster	PROPN
admet-2603	171	24	,	,	PUNCT
admet-2603	171	25	e.	e.	PROPN
admet-2603	171	26	lipka	lipka	PROPN
admet-2603	171	27	,	,	PUNCT
admet-2603	171	28	g.	g.	PROPN
admet-2603	171	29	amidon	amidon	PROPN
admet-2603	171	30	,	,	PUNCT
admet-2603	171	31	r.	r.	PROPN
admet-2603	171	32	löbenberg	löbenberg	PROPN
admet-2603	171	33	.	.	PUNCT
admet-2603	172	1	simulated	simulate	VERB
admet-2603	172	2	,	,	PUNCT
admet-2603	172	3	biorelevant	biorelevant	ADJ
admet-2603	172	4	,	,	PUNCT
admet-2603	172	5	clinically	clinically	ADV
admet-2603	172	6	relevant	relevant	ADJ
admet-2603	172	7	or	or	CCONJ
admet-2603	172	8	physiologically	physiologically	ADV
admet-2603	172	9	relevant	relevant	ADJ
admet-2603	172	10	dissolution	dissolution	NOUN
admet-2603	172	11	media	medium	NOUN
admet-2603	172	12	:	:	PUNCT
admet-2603	172	13	the	the	DET
admet-2603	172	14	hidden	hidden	ADJ
admet-2603	172	15	role	role	NOUN
admet-2603	172	16	of	of	ADP
admet-2603	172	17	bicarbonate	bicarbonate	NOUN
admet-2603	172	18	buffer	buffer	NOUN
admet-2603	172	19	.	.	PUNCT
admet-2603	173	1	european	european	ADJ
admet-2603	173	2	journal	journal	PROPN
admet-2603	173	3	of	of	ADP
admet-2603	173	4	pharmaceutics	pharmaceutic	NOUN
admet-2603	173	5	and	and	CCONJ
admet-2603	173	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2603	173	7	142	142	NUM
admet-2603	173	8	(	(	PUNCT
admet-2603	173	9	2019	2019	NUM
admet-2603	173	10	)	)	PUNCT
admet-2603	173	11	.	.	PUNCT
admet-2603	174	1	https://doi.org/10.1016/j.ejpb.2019.06.006	https://doi.org/10.1016/j.ejpb.2019.06.006	ADJ
admet-2603	174	2	[	[	X
admet-2603	174	3	4	4	NUM
admet-2603	174	4	]	]	X
admet-2603	174	5	j.e	j.e	PROPN
admet-2603	174	6	.	.	PROPN
admet-2603	174	7	boni	boni	PROPN
admet-2603	174	8	,	,	PUNCT
admet-2603	174	9	r.s	r.s	PROPN
admet-2603	174	10	.	.	PROPN
admet-2603	174	11	brickl	brickl	PROPN
admet-2603	174	12	,	,	PUNCT
admet-2603	174	13	j.	j.	PROPN
admet-2603	174	14	dressman	dressman	PROPN
admet-2603	174	15	.	.	PUNCT
admet-2603	174	16	is	be	AUX
admet-2603	174	17	bicarbonate	bicarbonate	NOUN
admet-2603	174	18	buffer	buffer	NOUN
admet-2603	174	19	suitable	suitable	ADJ
admet-2603	174	20	as	as	ADP
admet-2603	174	21	a	a	DET
admet-2603	174	22	dissolution	dissolution	ADJ
admet-2603	174	23	medium	medium	NOUN
admet-2603	174	24	?	?	PUNCT
admet-2603	174	25	journal	journal	NOUN
admet-2603	174	26	of	of	ADP
admet-2603	174	27	pharmacy	pharmacy	NOUN
admet-2603	174	28	and	and	CCONJ
admet-2603	174	29	pharmacology	pharmacology	NOUN
admet-2603	174	30	59	59	NUM
admet-2603	174	31	(	(	PUNCT
admet-2603	174	32	2010	2010	NUM
admet-2603	174	33	)	)	PUNCT
admet-2603	174	34	.	.	PUNCT
admet-2603	175	1	https://doi.org/10.1211/jpp.59.10.0007	https://doi.org/10.1211/jpp.59.10.0007	VERB
admet-2603	175	2	[	[	PUNCT
admet-2603	175	3	5	5	NUM
admet-2603	175	4	]	]	X
admet-2603	175	5	d.p	d.p	PROPN
admet-2603	175	6	.	.	PUNCT
admet-2603	175	7	mcnamara	mcnamara	PROPN
admet-2603	175	8	,	,	PUNCT
admet-2603	175	9	k.m	k.m	PROPN
admet-2603	175	10	.	.	PROPN
admet-2603	175	11	whitney	whitney	PROPN
admet-2603	175	12	,	,	PUNCT
admet-2603	175	13	s.l	s.l	PROPN
admet-2603	175	14	.	.	PROPN
admet-2603	175	15	goss	goss	PROPN
admet-2603	175	16	.	.	PUNCT
admet-2603	176	1	use	use	NOUN
admet-2603	176	2	of	of	ADP
admet-2603	176	3	a	a	DET
admet-2603	176	4	physiologic	physiologic	ADJ
admet-2603	176	5	bicarbonate	bicarbonate	NOUN
admet-2603	176	6	buffer	buffer	NOUN
admet-2603	176	7	system	system	NOUN
admet-2603	176	8	for	for	ADP
admet-2603	176	9	dissolution	dissolution	ADJ
admet-2603	176	10	characterization	characterization	NOUN
admet-2603	176	11	of	of	ADP
admet-2603	176	12	ionizable	ionizable	ADJ
admet-2603	176	13	drugs	drug	NOUN
admet-2603	176	14	.	.	PUNCT
admet-2603	177	1	pharmaceutical	pharmaceutical	ADJ
admet-2603	177	2	research	research	NOUN
admet-2603	177	3	20	20	NUM
admet-2603	177	4	(	(	PUNCT
admet-2603	177	5	2003	2003	NUM
admet-2603	177	6	)	)	PUNCT
admet-2603	177	7	1641	1641	NUM
admet-2603	177	8	-	-	SYM
admet-2603	177	9	1646	1646	NUM
admet-2603	177	10	.	.	PUNCT
admet-2603	178	1	https://doi.org/10.1023/a:1026147620304	https://doi.org/10.1023/a:1026147620304	PROPN
admet-2603	179	1	[	[	X
admet-2603	179	2	6	6	NUM
admet-2603	179	3	]	]	X
admet-2603	179	4	h.m	h.m	PROPN
admet-2603	179	5	.	.	PROPN
admet-2603	179	6	fadda	fadda	PROPN
admet-2603	179	7	,	,	PUNCT
admet-2603	179	8	h.a	h.a	PROPN
admet-2603	179	9	.	.	PROPN
admet-2603	179	10	merchant	merchant	PROPN
admet-2603	179	11	,	,	PUNCT
admet-2603	179	12	b.t	b.t	PROPN
admet-2603	179	13	.	.	PROPN
admet-2603	179	14	arafat	arafat	PROPN
admet-2603	179	15	,	,	PUNCT
admet-2603	179	16	a.w	a.w	PROPN
admet-2603	179	17	.	.	PROPN
admet-2603	179	18	basit	basit	PROPN
admet-2603	179	19	.	.	PUNCT
admet-2603	180	1	physiological	physiological	ADJ
admet-2603	180	2	bicarbonate	bicarbonate	NOUN
admet-2603	180	3	buffers	buffer	NOUN
admet-2603	180	4	:	:	PUNCT
admet-2603	180	5	stabilisation	stabilisation	NOUN
admet-2603	180	6	and	and	CCONJ
admet-2603	180	7	use	use	NOUN
admet-2603	180	8	as	as	ADP
admet-2603	180	9	dissolution	dissolution	ADJ
admet-2603	180	10	media	medium	NOUN
admet-2603	180	11	for	for	ADP
admet-2603	180	12	modified	modify	VERB
admet-2603	180	13	release	release	NOUN
admet-2603	180	14	systems	system	NOUN
admet-2603	180	15	.	.	PUNCT
admet-2603	181	1	international	international	ADJ
admet-2603	181	2	journal	journal	PROPN
admet-2603	181	3	of	of	ADP
admet-2603	181	4	pharmaceutics	pharmaceutic	NOUN
admet-2603	181	5	382	382	NUM
admet-2603	181	6	(	(	PUNCT
admet-2603	181	7	2009	2009	NUM
admet-2603	181	8	)	)	PUNCT
admet-2603	181	9	.	.	PUNCT
admet-2603	182	1	https://doi.org/10.1016/j.ijpharm.2009.08.003	https://doi.org/10.1016/j.ijpharm.2009.08.003	PROPN
admet-2603	182	2	[	[	X
admet-2603	182	3	7	7	NUM
admet-2603	182	4	]	]	X
admet-2603	182	5	g.	g.	NOUN
admet-2603	182	6	garbacz	garbacz	PROPN
admet-2603	182	7	,	,	PUNCT
admet-2603	182	8	b.	b.	PROPN
admet-2603	182	9	kołodziej	kołodziej	PROPN
admet-2603	182	10	,	,	PUNCT
admet-2603	182	11	m.	m.	NOUN
admet-2603	182	12	koziolek	koziolek	NOUN
admet-2603	182	13	,	,	PUNCT
admet-2603	182	14	w.	w.	PROPN
admet-2603	182	15	weitschies	weitschies	PROPN
admet-2603	182	16	,	,	PUNCT
admet-2603	182	17	s.	s.	PROPN
admet-2603	182	18	klein	klein	PROPN
admet-2603	182	19	.	.	PUNCT
admet-2603	183	1	an	an	DET
admet-2603	183	2	automated	automate	VERB
admet-2603	183	3	system	system	NOUN
admet-2603	183	4	for	for	ADP
admet-2603	183	5	monitoring	monitor	VERB
admet-2603	183	6	and	and	CCONJ
admet-2603	183	7	regulating	regulate	VERB
admet-2603	183	8	the	the	DET
admet-2603	183	9	ph	ph	NOUN
admet-2603	183	10	of	of	ADP
admet-2603	183	11	bicarbonate	bicarbonate	NOUN
admet-2603	183	12	buffers	buffer	NOUN
admet-2603	183	13	.	.	PUNCT
admet-2603	184	1	aaps	aap	NOUN
admet-2603	184	2	pharmscitech	pharmscitech	VERB
admet-2603	184	3	14	14	NUM
admet-2603	184	4	(	(	PUNCT
admet-2603	184	5	2013	2013	NUM
admet-2603	184	6	)	)	PUNCT
admet-2603	184	7	517	517	NUM
admet-2603	184	8	-	-	SYM
admet-2603	184	9	522	522	NUM
admet-2603	184	10	.	.	PUNCT
admet-2603	184	11	https://doi.org/10.1208/s12249-013-9933-5	https://doi.org/10.1208/s12249-013-9933-5	NUM
admet-2603	185	1	[	[	X
admet-2603	185	2	8	8	NUM
admet-2603	185	3	]	]	X
admet-2603	185	4	n.	n.	PROPN
admet-2603	185	5	scott	scott	PROPN
admet-2603	185	6	,	,	PUNCT
admet-2603	185	7	k.	k.	PROPN
admet-2603	185	8	patel	patel	PROPN
admet-2603	185	9	,	,	PUNCT
admet-2603	185	10	t.	t.	PROPN
admet-2603	185	11	sithole	sithole	PROPN
admet-2603	185	12	,	,	PUNCT
admet-2603	185	13	k.	k.	PROPN
admet-2603	185	14	xenofontos	xenofontos	PROPN
admet-2603	185	15	,	,	PUNCT
admet-2603	185	16	v.	v.	ADP
admet-2603	185	17	mohylyuk	mohylyuk	NOUN
admet-2603	185	18	,	,	PUNCT
admet-2603	185	19	f.	f.	PROPN
admet-2603	185	20	liu	liu	PROPN
admet-2603	185	21	.	.	PUNCT
admet-2603	186	1	regulating	regulate	VERB
admet-2603	186	2	the	the	DET
admet-2603	186	3	ph	ph	NOUN
admet-2603	186	4	of	of	ADP
admet-2603	186	5	bicarbonate	bicarbonate	NOUN
admet-2603	186	6	solutions	solution	NOUN
admet-2603	186	7	without	without	ADP
admet-2603	186	8	purging	purge	VERB
admet-2603	186	9	gases	gas	NOUN
admet-2603	186	10	:	:	PUNCT
admet-2603	186	11	application	application	NOUN
admet-2603	186	12	to	to	ADP
admet-2603	186	13	dissolution	dissolution	ADJ
admet-2603	186	14	testing	testing	NOUN
admet-2603	186	15	of	of	ADP
admet-2603	186	16	enteric	enteric	ADJ
admet-2603	186	17	coated	coated	ADJ
admet-2603	186	18	tablets	tablet	NOUN
admet-2603	186	19	,	,	PUNCT
admet-2603	186	20	pellets	pellet	NOUN
admet-2603	186	21	and	and	CCONJ
admet-2603	186	22	microparticles	microparticle	NOUN
admet-2603	186	23	.	.	PUNCT
admet-2603	187	1	international	international	ADJ
admet-2603	187	2	journal	journal	PROPN
admet-2603	187	3	of	of	ADP
admet-2603	187	4	pharmaceutics	pharmaceutic	NOUN
admet-2603	187	5	585	585	NUM
admet-2603	187	6	(	(	PUNCT
admet-2603	187	7	2020	2020	NUM
admet-2603	187	8	)	)	PUNCT
admet-2603	187	9	.	.	PUNCT
admet-2603	188	1	https://doi.org/10.1016/j.ijpharm.2020.119562	https://doi.org/10.1016/j.ijpharm.2020.119562	ADJ
admet-2603	188	2	[	[	X
admet-2603	188	3	9	9	NUM
admet-2603	188	4	]	]	PUNCT
admet-2603	188	5	a.	a.	NOUN
admet-2603	188	6	sakamoto	sakamoto	PROPN
admet-2603	188	7	,	,	PUNCT
admet-2603	188	8	k.	k.	PROPN
admet-2603	188	9	izutsu	izutsu	PROPN
admet-2603	188	10	,	,	PUNCT
admet-2603	188	11	h.	h.	PROPN
admet-2603	188	12	yoshida	yoshida	PROPN
admet-2603	188	13	,	,	PUNCT
admet-2603	188	14	y.	y.	PROPN
admet-2603	188	15	abe	abe	PROPN
admet-2603	188	16	,	,	PUNCT
admet-2603	188	17	d.	d.	PROPN
admet-2603	188	18	inoue	inoue	PROPN
admet-2603	188	19	,	,	PUNCT
admet-2603	188	20	k.	k.	PROPN
admet-2603	188	21	sugano	sugano	PROPN
admet-2603	188	22	.	.	PUNCT
admet-2603	189	1	simple	simple	ADJ
admet-2603	189	2	bicarbonate	bicarbonate	NOUN
admet-2603	189	3	buffer	buffer	NOUN
admet-2603	189	4	system	system	NOUN
admet-2603	189	5	for	for	ADP
admet-2603	189	6	dissolution	dissolution	ADJ
admet-2603	189	7	testing	testing	NOUN
admet-2603	189	8	:	:	PUNCT
admet-2603	189	9	floating	float	VERB
admet-2603	189	10	lid	lid	NOUN
admet-2603	189	11	method	method	NOUN
admet-2603	189	12	and	and	CCONJ
admet-2603	189	13	its	its	PRON
admet-2603	189	14	application	application	NOUN
admet-2603	189	15	to	to	ADP
admet-2603	189	16	colonic	colonic	ADJ
admet-2603	189	17	drug	drug	NOUN
admet-2603	189	18	delivery	delivery	NOUN
admet-2603	189	19	system	system	NOUN
admet-2603	189	20	.	.	PUNCT
admet-2603	190	1	journal	journal	PROPN
admet-2603	190	2	of	of	ADP
admet-2603	190	3	drug	drug	NOUN
admet-2603	190	4	delivery	delivery	NOUN
admet-2603	190	5	science	science	NOUN
admet-2603	190	6	and	and	CCONJ
admet-2603	190	7	technology	technology	NOUN
admet-2603	190	8	63	63	NUM
admet-2603	190	9	(	(	PUNCT
admet-2603	190	10	2021	2021	NUM
admet-2603	190	11	)	)	PUNCT
admet-2603	190	12	102447	102447	NUM
admet-2603	190	13	.	.	PUNCT
admet-2603	191	1	https://doi.org/10.1016/j.jddst.2021.102447	https://doi.org/10.1016/j.jddst.2021.102447	PROPN
admet-2603	191	2	[	[	X
admet-2603	191	3	10	10	NUM
admet-2603	191	4	]	]	PUNCT
admet-2603	191	5	a.	a.	NOUN
admet-2603	191	6	sakamoto	sakamoto	PROPN
admet-2603	191	7	,	,	PUNCT
admet-2603	191	8	k.	k.	PROPN
admet-2603	191	9	sugano	sugano	PROPN
admet-2603	191	10	.	.	PUNCT
admet-2603	192	1	dissolution	dissolution	PROPN
admet-2603	192	2	kinetics	kinetic	NOUN
admet-2603	192	3	of	of	ADP
admet-2603	192	4	nifedipine	nifedipine	NOUN
admet-2603	192	5	—	—	PUNCT
admet-2603	192	6	ionizable	ionizable	ADJ
admet-2603	192	7	polymer	polymer	NOUN
admet-2603	192	8	amorphous	amorphous	ADJ
admet-2603	192	9	solid	solid	ADJ
admet-2603	192	10	dispersion	dispersion	NOUN
admet-2603	192	11	:	:	PUNCT
admet-2603	192	12	comparison	comparison	NOUN
admet-2603	192	13	between	between	ADP
admet-2603	192	14	bicarbonate	bicarbonate	NOUN
admet-2603	192	15	and	and	CCONJ
admet-2603	192	16	phosphate	phosphate	ADJ
admet-2603	192	17	buffers	buffer	NOUN
admet-2603	192	18	.	.	PUNCT
admet-2603	193	1	pharmaceutical	pharmaceutical	ADJ
admet-2603	193	2	research	research	NOUN
admet-2603	193	3	38	38	NUM
admet-2603	193	4	(	(	PUNCT
admet-2603	193	5	2021	2021	NUM
admet-2603	193	6	)	)	PUNCT
admet-2603	193	7	2119	2119	NUM
admet-2603	193	8	-	-	SYM
admet-2603	193	9	2127	2127	NUM
admet-2603	193	10	.	.	PUNCT
admet-2603	194	1	https://doi.org/10.1007/s11095-021-03153-2	https://doi.org/10.1007/s11095-021-03153-2	NUM
admet-2603	195	1	[	[	X
admet-2603	195	2	11	11	NUM
admet-2603	195	3	]	]	PUNCT
admet-2603	195	4	s.	s.	PROPN
admet-2603	195	5	ikuta	ikuta	PROPN
admet-2603	195	6	,	,	PUNCT
admet-2603	195	7	h.	h.	PROPN
admet-2603	195	8	nakagawa	nakagawa	PROPN
admet-2603	195	9	,	,	PUNCT
admet-2603	195	10	t.	t.	PROPN
admet-2603	195	11	kai	kai	PROPN
admet-2603	195	12	,	,	PUNCT
admet-2603	195	13	k.	k.	PROPN
admet-2603	195	14	sugano	sugano	PROPN
admet-2603	195	15	.	.	PUNCT
admet-2603	196	1	development	development	NOUN
admet-2603	196	2	of	of	ADP
admet-2603	196	3	bicarbonate	bicarbonate	NOUN
admet-2603	196	4	buffer	buffer	NOUN
admet-2603	196	5	flow	flow	NOUN
admet-2603	196	6	-	-	PUNCT
admet-2603	196	7	through	through	ADP
admet-2603	196	8	cell	cell	NOUN
admet-2603	196	9	dissolution	dissolution	NOUN
admet-2603	196	10	test	test	NOUN
admet-2603	196	11	and	and	CCONJ
admet-2603	196	12	its	its	PRON
admet-2603	196	13	application	application	NOUN
admet-2603	196	14	in	in	ADP
admet-2603	196	15	prediction	prediction	NOUN
admet-2603	196	16	of	of	ADP
admet-2603	196	17	in	in	ADP
admet-2603	196	18	vivo	vivo	ADJ
admet-2603	196	19	performance	performance	NOUN
admet-2603	196	20	of	of	ADP
admet-2603	196	21	colon	colon	NOUN
admet-2603	196	22	targeting	target	VERB
admet-2603	196	23	tablets	tablet	NOUN
admet-2603	196	24	.	.	PUNCT
admet-2603	197	1	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	PROPN
admet-2603	197	2	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	VERB
admet-2603	197	3	https://doi.org/10.1007/s11095-019-2731-3	https://doi.org/10.1007/s11095-019-2731-3	PROPN
admet-2603	197	4	https://doi.org/10.1016/j.ejpb.2019.06.006	https://doi.org/10.1016/j.ejpb.2019.06.006	PROPN
admet-2603	197	5	https://doi.org/10.1211/jpp.59.10.0007	https://doi.org/10.1211/jpp.59.10.0007	PROPN
admet-2603	197	6	https://doi.org/10.1023/a:1026147620304	https://doi.org/10.1023/a:1026147620304	PROPN
admet-2603	197	7	https://doi.org/10.1016/j.ijpharm.2009.08.003	https://doi.org/10.1016/j.ijpharm.2009.08.003	ADJ
admet-2603	197	8	https://doi.org/10.1208/s12249-013-9933-5	https://doi.org/10.1208/s12249-013-9933-5	NUM
admet-2603	197	9	https://doi.org/10.1016/j.ijpharm.2020.119562	https://doi.org/10.1016/j.ijpharm.2020.119562	PROPN
admet-2603	197	10	https://doi.org/10.1016/j.jddst.2021.102447	https://doi.org/10.1016/j.jddst.2021.102447	PROPN
admet-2603	197	11	https://doi.org/10.1007/s11095-021-03153-2	https://doi.org/10.1007/s11095-021-03153-2	NUM
admet-2603	197	12	s.	s.	PROPN
admet-2603	197	13	ishida	ishida	PROPN
admet-2603	197	14	et	et	PROPN
admet-2603	197	15	al	al	PROPN
admet-2603	197	16	.	.	PROPN
admet-2603	197	17	admet	admet	PROPN
admet-2603	197	18	&	&	CCONJ
admet-2603	197	19	dmpk	dmpk	PROPN
admet-2603	197	20	13(1	13(1	NUM
admet-2603	197	21	)	)	PUNCT
admet-2603	197	22	(	(	PUNCT
admet-2603	197	23	2025	2025	NUM
admet-2603	197	24	)	)	PUNCT
admet-2603	197	25	2603	2603	NUM
admet-2603	198	1	8	8	NUM
admet-2603	198	2	european	european	ADJ
admet-2603	198	3	journal	journal	PROPN
admet-2603	198	4	of	of	ADP
admet-2603	198	5	pharmaceutical	pharmaceutical	PROPN
admet-2603	198	6	sciences	science	NOUN
admet-2603	198	7	180	180	NUM
admet-2603	198	8	(	(	PUNCT
admet-2603	198	9	2023	2023	NUM
admet-2603	198	10	)	)	PUNCT
admet-2603	198	11	106326	106326	NUM
admet-2603	198	12	.	.	PUNCT
admet-2603	199	1	https://doi.org/10.1016/j.ejps.2022.106326	https://doi.org/10.1016/j.ejps.2022.106326	PROPN
admet-2603	199	2	[	[	X
admet-2603	199	3	12	12	NUM
admet-2603	199	4	]	]	PUNCT
admet-2603	199	5	j.	j.	PROPN
admet-2603	199	6	al	al	PROPN
admet-2603	199	7	-	-	PUNCT
admet-2603	199	8	gousous	gousous	ADJ
admet-2603	199	9	,	,	PUNCT
admet-2603	199	10	n.	n.	PROPN
admet-2603	199	11	salehi	salehi	PROPN
admet-2603	199	12	,	,	PUNCT
admet-2603	199	13	g.e	g.e	PROPN
admet-2603	199	14	.	.	PROPN
admet-2603	199	15	amidon	amidon	PROPN
admet-2603	199	16	,	,	PUNCT
admet-2603	199	17	r.m	r.m	PROPN
admet-2603	199	18	.	.	PROPN
admet-2603	199	19	ziff	ziff	PROPN
admet-2603	199	20	,	,	PUNCT
admet-2603	199	21	p.	p.	PROPN
admet-2603	199	22	langguth	langguth	PROPN
admet-2603	199	23	,	,	PUNCT
admet-2603	199	24	g.l	g.l	PROPN
admet-2603	199	25	.	.	PROPN
admet-2603	199	26	amidon	amidon	PROPN
admet-2603	199	27	.	.	PUNCT
admet-2603	200	1	mass	mass	PROPN
admet-2603	200	2	transport	transport	NOUN
admet-2603	200	3	analysis	analysis	NOUN
admet-2603	200	4	of	of	ADP
admet-2603	200	5	bicarbonate	bicarbonate	NOUN
admet-2603	200	6	buffer	buffer	NOUN
admet-2603	200	7	:	:	PUNCT
admet-2603	200	8	effect	effect	NOUN
admet-2603	200	9	of	of	ADP
admet-2603	200	10	the	the	DET
admet-2603	200	11	co2	co2	NOUN
admet-2603	200	12	-	-	PUNCT
admet-2603	200	13	h2co3	h2co3	NOUN
admet-2603	200	14	hydration	hydration	NOUN
admet-2603	200	15	-	-	PUNCT
admet-2603	200	16	dehydration	dehydration	NOUN
admet-2603	200	17	kinetics	kinetic	NOUN
admet-2603	200	18	in	in	ADP
admet-2603	200	19	the	the	DET
admet-2603	200	20	fluid	fluid	ADJ
admet-2603	200	21	boundary	boundary	ADJ
admet-2603	200	22	layer	layer	NOUN
admet-2603	200	23	and	and	CCONJ
admet-2603	200	24	the	the	DET
admet-2603	200	25	apparent	apparent	ADJ
admet-2603	200	26	effective	effective	ADJ
admet-2603	200	27	p	p	PROPN
admet-2603	200	28	ka	ka	PROPN
admet-2603	200	29	controlling	control	VERB
admet-2603	200	30	dissolution	dissolution	NOUN
admet-2603	200	31	of	of	ADP
admet-2603	200	32	acids	acid	NOUN
admet-2603	200	33	and	and	CCONJ
admet-2603	200	34	bases	basis	NOUN
admet-2603	200	35	.	.	PUNCT
admet-2603	201	1	molecular	molecular	ADJ
admet-2603	201	2	pharmaceutics	pharmaceutic	NOUN
admet-2603	201	3	16	16	NUM
admet-2603	201	4	(	(	PUNCT
admet-2603	201	5	2019	2019	NUM
admet-2603	201	6	)	)	PUNCT
admet-2603	201	7	2626	2626	NUM
admet-2603	201	8	-	-	SYM
admet-2603	201	9	2635	2635	NUM
admet-2603	201	10	.	.	PUNCT
admet-2603	202	1	https://doi.org/10.1021/acs.molpharmaceut.9b00187	https://doi.org/10.1021/acs.molpharmaceut.9b00187	PRON
admet-2603	203	1	[	[	X
admet-2603	203	2	13	13	NUM
admet-2603	203	3	]	]	X
admet-2603	203	4	b.j	b.j	PROPN
admet-2603	203	5	.	.	PROPN
admet-2603	203	6	krieg	krieg	PROPN
admet-2603	203	7	,	,	PUNCT
admet-2603	203	8	s.m	s.m	PROPN
admet-2603	203	9	.	.	PROPN
admet-2603	203	10	taghavi	taghavi	PROPN
admet-2603	203	11	,	,	PUNCT
admet-2603	203	12	g.l	g.l	PROPN
admet-2603	203	13	.	.	PROPN
admet-2603	203	14	amidon	amidon	PROPN
admet-2603	203	15	,	,	PUNCT
admet-2603	203	16	g.e	g.e	PROPN
admet-2603	203	17	.	.	PROPN
admet-2603	203	18	amidon	amidon	PROPN
admet-2603	203	19	.	.	PUNCT
admet-2603	204	1	in	in	ADP
admet-2603	204	2	vivo	vivo	ADJ
admet-2603	204	3	predictive	predictive	ADJ
admet-2603	204	4	dissolution	dissolution	NOUN
admet-2603	204	5	:	:	PUNCT
admet-2603	204	6	comparing	compare	VERB
admet-2603	204	7	the	the	DET
admet-2603	204	8	effect	effect	NOUN
admet-2603	204	9	of	of	ADP
admet-2603	204	10	bicarbonate	bicarbonate	NOUN
admet-2603	204	11	and	and	CCONJ
admet-2603	204	12	phosphate	phosphate	ADJ
admet-2603	204	13	buffer	buffer	NOUN
admet-2603	204	14	on	on	ADP
admet-2603	204	15	the	the	DET
admet-2603	204	16	dissolution	dissolution	NOUN
admet-2603	204	17	of	of	ADP
admet-2603	204	18	weak	weak	ADJ
admet-2603	204	19	acids	acid	NOUN
admet-2603	204	20	and	and	CCONJ
admet-2603	204	21	weak	weak	ADJ
admet-2603	204	22	bases	basis	NOUN
admet-2603	204	23	.	.	PUNCT
admet-2603	205	1	journal	journal	NOUN
admet-2603	205	2	of	of	ADP
admet-2603	205	3	pharmaceutical	pharmaceutical	PROPN
admet-2603	205	4	sciences	science	NOUN
admet-2603	205	5	104	104	NUM
admet-2603	205	6	(	(	PUNCT
admet-2603	205	7	2015	2015	NUM
admet-2603	205	8	)	)	PUNCT
admet-2603	205	9	2894	2894	NUM
admet-2603	205	10	-	-	SYM
admet-2603	205	11	2904	2904	NUM
admet-2603	205	12	.	.	PUNCT
admet-2603	206	1	https://doi.org/10.1002/jps.24460	https://doi.org/10.1002/jps.24460	ADJ
admet-2603	206	2	[	[	X
admet-2603	206	3	14	14	NUM
admet-2603	206	4	]	]	X
admet-2603	206	5	j.j	j.j	PROPN
admet-2603	206	6	.	.	PROPN
admet-2603	206	7	sheng	sheng	PROPN
admet-2603	206	8	,	,	PUNCT
admet-2603	206	9	d.p	d.p	PROPN
admet-2603	206	10	.	.	PROPN
admet-2603	206	11	mcnamara	mcnamara	PROPN
admet-2603	206	12	,	,	PUNCT
admet-2603	206	13	g.l	g.l	PROPN
admet-2603	206	14	.	.	PROPN
admet-2603	206	15	amidon	amidon	PROPN
admet-2603	206	16	.	.	PUNCT
admet-2603	207	1	toward	toward	ADP
admet-2603	207	2	an	an	DET
admet-2603	207	3	in	in	ADP
admet-2603	207	4	vivo	vivo	ADJ
admet-2603	207	5	dissolution	dissolution	NOUN
admet-2603	207	6	methodology	methodology	NOUN
admet-2603	207	7	:	:	PUNCT
admet-2603	207	8	a	a	DET
admet-2603	207	9	comparison	comparison	NOUN
admet-2603	207	10	of	of	ADP
admet-2603	207	11	phosphate	phosphate	NOUN
admet-2603	207	12	and	and	CCONJ
admet-2603	207	13	bicarbonate	bicarbonate	NOUN
admet-2603	207	14	buffers	buffer	NOUN
admet-2603	207	15	.	.	PUNCT
admet-2603	208	1	molecular	molecular	ADJ
admet-2603	208	2	pharmaceutics	pharmaceutic	NOUN
admet-2603	208	3	6	6	NUM
admet-2603	208	4	(	(	PUNCT
admet-2603	208	5	2009	2009	NUM
admet-2603	208	6	)	)	PUNCT
admet-2603	208	7	29	29	NUM
admet-2603	208	8	-	-	SYM
admet-2603	208	9	39	39	NUM
admet-2603	208	10	.	.	PUNCT
admet-2603	208	11	https://doi.org/10.1021/mp800148u	https://doi.org/10.1021/mp800148u	PROPN
admet-2603	209	1	[	[	X
admet-2603	209	2	15	15	NUM
admet-2603	209	3	]	]	X
admet-2603	209	4	k.	k.	PROPN
admet-2603	209	5	krollik	krollik	PROPN
admet-2603	209	6	,	,	PUNCT
admet-2603	209	7	a.	a.	PROPN
admet-2603	209	8	lehmann	lehmann	PROPN
admet-2603	209	9	,	,	PUNCT
admet-2603	209	10	c.	c.	PROPN
admet-2603	209	11	wagner	wagner	PROPN
admet-2603	209	12	,	,	PUNCT
admet-2603	209	13	j.	j.	PROPN
admet-2603	209	14	kaidas	kaidas	PROPN
admet-2603	209	15	,	,	PUNCT
admet-2603	209	16	h.	h.	PROPN
admet-2603	209	17	kubas	kubas	PROPN
admet-2603	209	18	,	,	PUNCT
admet-2603	209	19	w.	w.	PROPN
admet-2603	209	20	weitschies	weitschie	NOUN
admet-2603	209	21	.	.	PUNCT
admet-2603	210	1	the	the	DET
admet-2603	210	2	effect	effect	NOUN
admet-2603	210	3	of	of	ADP
admet-2603	210	4	buffer	buffer	NOUN
admet-2603	210	5	species	specie	NOUN
admet-2603	210	6	on	on	ADP
admet-2603	210	7	biorelevant	biorelevant	ADJ
admet-2603	210	8	dissolution	dissolution	NOUN
admet-2603	210	9	and	and	CCONJ
admet-2603	210	10	precipitation	precipitation	NOUN
admet-2603	210	11	assays	assay	VERB
admet-2603	210	12	comparison	comparison	NOUN
admet-2603	210	13	of	of	ADP
admet-2603	210	14	phosphate	phosphate	NOUN
admet-2603	210	15	and	and	CCONJ
admet-2603	210	16	bicarbonate	bicarbonate	NOUN
admet-2603	210	17	buffer	buffer	NOUN
admet-2603	210	18	.	.	PUNCT
admet-2603	211	1	european	european	ADJ
admet-2603	211	2	journal	journal	PROPN
admet-2603	211	3	of	of	ADP
admet-2603	211	4	pharmaceutics	pharmaceutic	NOUN
admet-2603	211	5	and	and	CCONJ
admet-2603	211	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2603	211	7	171	171	NUM
admet-2603	211	8	(	(	PUNCT
admet-2603	211	9	2022	2022	NUM
admet-2603	211	10	)	)	PUNCT
admet-2603	211	11	90	90	NUM
admet-2603	211	12	-	-	SYM
admet-2603	211	13	101	101	NUM
admet-2603	211	14	https://doi.org/10.1016/j.ejpb.2021.09.009	https://doi.org/10.1016/j.ejpb.2021.09.009	PROPN
admet-2603	211	15	[	[	X
admet-2603	211	16	16	16	NUM
admet-2603	211	17	]	]	PUNCT
admet-2603	211	18	a.	a.	NOUN
admet-2603	211	19	sakamoto	sakamoto	PROPN
admet-2603	211	20	,	,	PUNCT
admet-2603	211	21	k.	k.	PROPN
admet-2603	211	22	sugano	sugano	PROPN
admet-2603	211	23	.	.	PUNCT
admet-2603	212	1	dissolution	dissolution	ADJ
admet-2603	212	2	profiles	profile	NOUN
admet-2603	212	3	of	of	ADP
admet-2603	212	4	poorly	poorly	ADV
admet-2603	212	5	soluble	soluble	ADJ
admet-2603	212	6	drug	drug	NOUN
admet-2603	212	7	salts	salt	NOUN
admet-2603	212	8	in	in	ADP
admet-2603	212	9	bicarbonate	bicarbonate	NOUN
admet-2603	212	10	buffer	buffer	NOUN
admet-2603	212	11	.	.	PUNCT
admet-2603	213	1	pharmaceutical	pharmaceutical	NOUN
admet-2603	213	2	research	research	NOUN
admet-2603	213	3	40	40	NUM
admet-2603	213	4	(	(	PUNCT
admet-2603	213	5	2023	2023	NUM
admet-2603	213	6	)	)	PUNCT
admet-2603	213	7	989	989	NUM
admet-2603	213	8	-	-	SYM
admet-2603	213	9	998	998	NUM
admet-2603	213	10	.	.	PUNCT
admet-2603	214	1	https://doi.org/10.1007/s11095-023-03508-x	https://doi.org/10.1007/s11095-023-03508-x	PROPN
admet-2603	215	1	[	[	X
admet-2603	215	2	17	17	NUM
admet-2603	215	3	]	]	PUNCT
admet-2603	215	4	h.	h.	PROPN
admet-2603	215	5	yamamoto	yamamoto	PROPN
admet-2603	215	6	,	,	PUNCT
admet-2603	215	7	k.	k.	PROPN
admet-2603	215	8	sugano	sugano	PROPN
admet-2603	215	9	.	.	PUNCT
admet-2603	216	1	drug	drug	NOUN
admet-2603	216	2	crystal	crystal	PROPN
admet-2603	216	3	precipitation	precipitation	NOUN
admet-2603	216	4	in	in	ADP
admet-2603	216	5	biorelevant	biorelevant	ADJ
admet-2603	216	6	bicarbonate	bicarbonate	NOUN
admet-2603	216	7	buffer	buffer	NOUN
admet-2603	216	8	:	:	PUNCT
admet-2603	216	9	a	a	DET
admet-2603	216	10	wellcontrolled	wellcontrolle	VERB
admet-2603	216	11	comparative	comparative	ADJ
admet-2603	216	12	study	study	NOUN
admet-2603	216	13	with	with	ADP
admet-2603	216	14	phosphate	phosphate	ADJ
admet-2603	216	15	buffer	buffer	NOUN
admet-2603	216	16	.	.	PUNCT
admet-2603	217	1	molecular	molecular	ADJ
admet-2603	217	2	pharmaceutics	pharmaceutic	NOUN
admet-2603	217	3	21	21	NUM
admet-2603	217	4	(	(	PUNCT
admet-2603	217	5	2024	2024	NUM
admet-2603	217	6	)	)	PUNCT
admet-2603	217	7	28542864	28542864	NUM
admet-2603	217	8	.	.	PUNCT
admet-2603	218	1	https://doi.org/10.1021/acs.molpharmaceut.4c00028	https://doi.org/10.1021/acs.molpharmaceut.4c00028	NOUN
admet-2603	218	2	[	[	X
admet-2603	218	3	18	18	NUM
admet-2603	218	4	]	]	PUNCT
admet-2603	218	5	j.	j.	PROPN
admet-2603	218	6	al	al	PROPN
admet-2603	218	7	-	-	PUNCT
admet-2603	218	8	gousous	gousous	ADJ
admet-2603	218	9	,	,	PUNCT
admet-2603	218	10	k.x	k.x	PROPN
admet-2603	218	11	.	.	PROPN
admet-2603	218	12	sun	sun	PROPN
admet-2603	218	13	,	,	PUNCT
admet-2603	218	14	d.p	d.p	PROPN
admet-2603	218	15	.	.	PROPN
admet-2603	218	16	mcnamara	mcnamara	PROPN
admet-2603	218	17	,	,	PUNCT
admet-2603	218	18	b.	b.	PROPN
admet-2603	218	19	hens	hens	PROPN
admet-2603	218	20	,	,	PUNCT
admet-2603	218	21	n.	n.	NOUN
admet-2603	218	22	salehi	salehi	PROPN
admet-2603	218	23	,	,	PUNCT
admet-2603	218	24	p.	p.	PROPN
admet-2603	218	25	langguth	langguth	NOUN
admet-2603	218	26	,	,	PUNCT
admet-2603	218	27	m.	m.	NOUN
admet-2603	218	28	bermejo	bermejo	PROPN
admet-2603	218	29	,	,	PUNCT
admet-2603	218	30	g.e	g.e	PROPN
admet-2603	218	31	.	.	PROPN
admet-2603	218	32	amidon	amidon	PROPN
admet-2603	218	33	,	,	PUNCT
admet-2603	218	34	g.l	g.l	PROPN
admet-2603	218	35	.	.	PROPN
admet-2603	218	36	amidon	amidon	PROPN
admet-2603	218	37	.	.	PUNCT
admet-2603	219	1	mass	mass	PROPN
admet-2603	219	2	transport	transport	NOUN
admet-2603	219	3	analysis	analysis	NOUN
admet-2603	219	4	of	of	ADP
admet-2603	219	5	the	the	DET
admet-2603	219	6	enhanced	enhance	VERB
admet-2603	219	7	buffer	buffer	NOUN
admet-2603	219	8	capacity	capacity	NOUN
admet-2603	219	9	of	of	ADP
admet-2603	219	10	the	the	DET
admet-2603	219	11	bicarbonate	bicarbonate	NOUN
admet-2603	219	12	-	-	PUNCT
admet-2603	219	13	co2	co2	NOUN
admet-2603	219	14	buffer	buffer	NOUN
admet-2603	219	15	in	in	ADP
admet-2603	219	16	a	a	DET
admet-2603	219	17	phase	phase	NOUN
admet-2603	219	18	-	-	PUNCT
admet-2603	219	19	heterogenous	heterogenous	ADJ
admet-2603	219	20	system	system	NOUN
admet-2603	219	21	:	:	PUNCT
admet-2603	219	22	physiological	physiological	ADJ
admet-2603	219	23	and	and	CCONJ
admet-2603	219	24	pharmaceutical	pharmaceutical	NOUN
admet-2603	219	25	significance	significance	NOUN
admet-2603	219	26	.	.	PUNCT
admet-2603	220	1	molecular	molecular	ADJ
admet-2603	220	2	pharmaceutics	pharmaceutic	NOUN
admet-2603	220	3	15	15	NUM
admet-2603	220	4	(	(	PUNCT
admet-2603	220	5	2018	2018	NUM
admet-2603	220	6	)	)	PUNCT
admet-2603	220	7	5291	5291	NUM
admet-2603	220	8	-	-	SYM
admet-2603	220	9	5301	5301	NUM
admet-2603	220	10	.	.	PUNCT
admet-2603	221	1	https://doi.org/10.1021/acs.molpharmaceut.8b00783	https://doi.org/10.1021/acs.molpharmaceut.8b00783	PRON
admet-2603	222	1	[	[	X
admet-2603	222	2	19	19	NUM
admet-2603	222	3	]	]	X
admet-2603	222	4	y.	y.	PROPN
admet-2603	222	5	tarumi	tarumi	PROPN
admet-2603	222	6	,	,	PUNCT
admet-2603	222	7	k.	k.	PROPN
admet-2603	222	8	sugano	sugano	PROPN
admet-2603	222	9	.	.	PUNCT
admet-2603	223	1	dissolution	dissolution	ADJ
admet-2603	223	2	profiles	profile	NOUN
admet-2603	223	3	of	of	ADP
admet-2603	223	4	high	high	ADJ
admet-2603	223	5	-	-	PUNCT
admet-2603	223	6	dose	dose	NOUN
admet-2603	223	7	salt	salt	NOUN
admet-2603	223	8	-	-	PUNCT
admet-2603	223	9	form	form	NOUN
admet-2603	223	10	drugs	drug	NOUN
admet-2603	223	11	in	in	ADP
admet-2603	223	12	bicarbonate	bicarbonate	NOUN
admet-2603	223	13	buffer	buffer	NOUN
admet-2603	223	14	and	and	CCONJ
admet-2603	223	15	phosphate	phosphate	ADJ
admet-2603	223	16	buffer	buffer	NOUN
admet-2603	223	17	.	.	PUNCT
admet-2603	224	1	journal	journal	NOUN
admet-2603	224	2	of	of	ADP
admet-2603	224	3	pharmaceutical	pharmaceutical	PROPN
admet-2603	224	4	sciences	science	NOUN
admet-2603	224	5	114	114	NUM
admet-2603	224	6	(	(	PUNCT
admet-2603	224	7	2025	2025	NUM
admet-2603	224	8	)	)	PUNCT
admet-2603	224	9	477	477	NUM
admet-2603	224	10	-	-	SYM
admet-2603	224	11	485	485	NUM
admet-2603	224	12	.	.	PUNCT
admet-2603	225	1	https://doi.org/10.1016/j.xphs.2024.10.025	https://doi.org/10.1016/j.xphs.2024.10.025	NUM
admet-2603	225	2	[	[	X
admet-2603	225	3	20	20	NUM
admet-2603	225	4	]	]	PUNCT
admet-2603	225	5	a.	a.	NOUN
admet-2603	225	6	avdeef	avdeef	PROPN
admet-2603	225	7	.	.	PUNCT
admet-2603	226	1	absorption	absorption	NOUN
admet-2603	226	2	and	and	CCONJ
admet-2603	226	3	drug	drug	NOUN
admet-2603	226	4	development	development	NOUN
admet-2603	226	5	:	:	PUNCT
admet-2603	226	6	solubility	solubility	NOUN
admet-2603	226	7	,	,	PUNCT
admet-2603	226	8	permeability	permeability	NOUN
admet-2603	226	9	,	,	PUNCT
admet-2603	226	10	and	and	CCONJ
admet-2603	226	11	charge	charge	NOUN
admet-2603	226	12	state	state	NOUN
admet-2603	226	13	,	,	PUNCT
admet-2603	226	14	second	second	ADJ
admet-2603	226	15	edition	edition	NOUN
admet-2603	226	16	,	,	PUNCT
admet-2603	226	17	john	john	PROPN
admet-2603	226	18	wiley	wiley	PROPN
admet-2603	226	19	&	&	CCONJ
admet-2603	226	20	sons	sons	PROPN
admet-2603	226	21	,	,	PUNCT
admet-2603	226	22	inc	inc	PROPN
admet-2603	226	23	.	.	PROPN
admet-2603	226	24	,	,	PUNCT
admet-2603	226	25	2012	2012	NUM
admet-2603	226	26	.	.	PUNCT
admet-2603	227	1	isbn	isbn	ADJ
admet-2603	227	2	:	:	PUNCT
admet-2603	227	3	978	978	NUM
admet-2603	227	4	-	-	SYM
admet-2603	227	5	1	1	NUM
admet-2603	227	6	-	-	PUNCT
admet-2603	227	7	118	118	NUM
admet-2603	227	8	-	-	PUNCT
admet-2603	227	9	28603	28603	NUM
admet-2603	227	10	-	-	SYM
admet-2603	227	11	6	6	NUM
admet-2603	227	12	[	[	SYM
admet-2603	227	13	21	21	NUM
admet-2603	227	14	]	]	X
admet-2603	227	15	h.	h.	NOUN
admet-2603	227	16	sudaki	sudaki	PROPN
admet-2603	227	17	,	,	PUNCT
admet-2603	227	18	k.	k.	PROPN
admet-2603	227	19	fujimoto	fujimoto	PROPN
admet-2603	227	20	,	,	PUNCT
admet-2603	227	21	k.	k.	PROPN
admet-2603	227	22	wada	wada	PROPN
admet-2603	227	23	,	,	PUNCT
admet-2603	227	24	k.	k.	PROPN
admet-2603	227	25	sugano	sugano	PROPN
admet-2603	227	26	.	.	PUNCT
admet-2603	228	1	phosphate	phosphate	ADJ
admet-2603	228	2	buffer	buffer	NOUN
admet-2603	228	3	interferes	interfere	VERB
admet-2603	228	4	dissolution	dissolution	NOUN
admet-2603	228	5	of	of	ADP
admet-2603	228	6	prazosin	prazosin	NOUN
admet-2603	228	7	hydrochloride	hydrochloride	NOUN
admet-2603	228	8	in	in	ADP
admet-2603	228	9	compendial	compendial	ADJ
admet-2603	228	10	dissolution	dissolution	NOUN
admet-2603	228	11	testing	testing	NOUN
admet-2603	228	12	.	.	PUNCT
admet-2603	229	1	drug	drug	NOUN
admet-2603	229	2	metabolism	metabolism	NOUN
admet-2603	229	3	and	and	CCONJ
admet-2603	229	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2603	229	5	51	51	NUM
admet-2603	229	6	(	(	PUNCT
admet-2603	229	7	2023	2023	NUM
admet-2603	229	8	)	)	PUNCT
admet-2603	229	9	100519	100519	NUM
admet-2603	229	10	.	.	PUNCT
admet-2603	230	1	https://doi.org/10.1016/j.dmpk.2023.100519	https://doi.org/10.1016/j.dmpk.2023.100519	PROPN
admet-2603	230	2	[	[	X
admet-2603	230	3	22	22	NUM
admet-2603	230	4	]	]	X
admet-2603	230	5	n.	n.	PROPN
admet-2603	230	6	okamoto	okamoto	PROPN
admet-2603	230	7	,	,	PUNCT
admet-2603	230	8	m.	m.	NOUN
admet-2603	230	9	higashino	higashino	PROPN
admet-2603	230	10	,	,	PUNCT
admet-2603	230	11	h.	h.	PROPN
admet-2603	230	12	yamamoto	yamamoto	PROPN
admet-2603	230	13	,	,	PUNCT
admet-2603	230	14	k.	k.	PROPN
admet-2603	230	15	sugano	sugano	PROPN
admet-2603	230	16	.	.	PUNCT
admet-2603	231	1	dissolution	dissolution	ADJ
admet-2603	231	2	profiles	profile	NOUN
admet-2603	231	3	of	of	ADP
admet-2603	231	4	immediate	immediate	ADJ
admet-2603	231	5	release	release	NOUN
admet-2603	231	6	products	product	NOUN
admet-2603	231	7	of	of	ADP
admet-2603	231	8	various	various	ADJ
admet-2603	231	9	drugs	drug	NOUN
admet-2603	231	10	in	in	ADP
admet-2603	231	11	biorelevant	biorelevant	ADJ
admet-2603	231	12	bicarbonate	bicarbonate	NOUN
admet-2603	231	13	buffer	buffer	NOUN
admet-2603	231	14	:	:	PUNCT
admet-2603	231	15	comparison	comparison	NOUN
admet-2603	231	16	with	with	ADP
admet-2603	231	17	compendial	compendial	ADJ
admet-2603	231	18	phosphate	phosphate	NOUN
admet-2603	231	19	buffer	buffer	NOUN
admet-2603	231	20	.	.	PUNCT
admet-2603	232	1	pharmaceutical	pharmaceutical	NOUN
admet-2603	232	2	research	research	NOUN
admet-2603	232	3	41	41	NUM
admet-2603	232	4	(	(	PUNCT
admet-2603	232	5	2024	2024	NUM
admet-2603	232	6	)	)	PUNCT
admet-2603	232	7	959	959	NUM
admet-2603	232	8	-	-	SYM
admet-2603	232	9	966	966	NUM
admet-2603	232	10	.	.	PUNCT
admet-2603	233	1	https://doi.org/10.1007/s11095024-03701-6	https://doi.org/10.1007/s11095024-03701-6	X
admet-2603	234	1	[	[	X
admet-2603	234	2	23	23	X
admet-2603	234	3	]	]	X
admet-2603	234	4	s.	s.	PROPN
admet-2603	234	5	ikuta	ikuta	PROPN
admet-2603	234	6	,	,	PUNCT
admet-2603	234	7	h.	h.	PROPN
admet-2603	234	8	nakagawa	nakagawa	PROPN
admet-2603	234	9	,	,	PUNCT
admet-2603	234	10	t.	t.	PROPN
admet-2603	234	11	kai	kai	PROPN
admet-2603	234	12	,	,	PUNCT
admet-2603	234	13	k.	k.	PROPN
admet-2603	234	14	sugano	sugano	PROPN
admet-2603	234	15	.	.	PUNCT
admet-2603	235	1	bicarbonate	bicarbonate	NOUN
admet-2603	235	2	buffer	buffer	NOUN
admet-2603	235	3	dissolution	dissolution	NOUN
admet-2603	235	4	test	test	NOUN
admet-2603	235	5	with	with	ADP
admet-2603	235	6	gentle	gentle	ADJ
admet-2603	235	7	mechanistic	mechanistic	ADJ
admet-2603	235	8	stress	stress	NOUN
admet-2603	235	9	for	for	ADP
admet-2603	235	10	bioequivalence	bioequivalence	NOUN
admet-2603	235	11	prediction	prediction	NOUN
admet-2603	235	12	of	of	ADP
admet-2603	235	13	enteric	enteric	ADJ
admet-2603	235	14	-	-	PUNCT
admet-2603	235	15	coated	coat	VERB
admet-2603	235	16	pellet	pellet	NOUN
admet-2603	235	17	formulations	formulation	NOUN
admet-2603	235	18	.	.	PUNCT
admet-2603	236	1	european	european	ADJ
admet-2603	236	2	journal	journal	PROPN
admet-2603	236	3	of	of	ADP
admet-2603	236	4	pharmaceutical	pharmaceutical	PROPN
admet-2603	236	5	sciences	science	NOUN
admet-2603	236	6	192	192	NUM
admet-2603	236	7	(	(	PUNCT
admet-2603	236	8	2024	2024	NUM
admet-2603	236	9	)	)	PUNCT
admet-2603	236	10	106622	106622	NUM
admet-2603	236	11	.	.	PUNCT
admet-2603	237	1	https://doi.org/10.1016/j.ejps.2023.106622	https://doi.org/10.1016/j.ejps.2023.106622	PROPN
admet-2603	237	2	[	[	X
admet-2603	237	3	24	24	NUM
admet-2603	237	4	]	]	PUNCT
admet-2603	237	5	m.	m.	NOUN
admet-2603	237	6	higashino	higashino	PROPN
admet-2603	237	7	,	,	PUNCT
admet-2603	237	8	k.	k.	PROPN
admet-2603	237	9	sugano	sugano	PROPN
admet-2603	237	10	.	.	PUNCT
admet-2603	238	1	dissolution	dissolution	ADJ
admet-2603	238	2	profiles	profile	NOUN
admet-2603	238	3	of	of	ADP
admet-2603	238	4	oral	oral	ADJ
admet-2603	238	5	disintegrating	disintegrate	VERB
admet-2603	238	6	tablet	tablet	NOUN
admet-2603	238	7	with	with	ADP
admet-2603	238	8	taste	taste	NOUN
admet-2603	238	9	masking	mask	VERB
admet-2603	238	10	granule	granule	NOUN
admet-2603	238	11	polymer	polymer	NOUN
admet-2603	238	12	coating	coating	NOUN
admet-2603	238	13	in	in	ADP
admet-2603	238	14	biorelevant	biorelevant	ADJ
admet-2603	238	15	bicarbonate	bicarbonate	NOUN
admet-2603	238	16	buffer	buffer	NOUN
admet-2603	238	17	.	.	PUNCT
admet-2603	239	1	chemical	chemical	NOUN
admet-2603	239	2	and	and	CCONJ
admet-2603	239	3	pharmaceutical	pharmaceutical	ADJ
admet-2603	239	4	bulletin	bulletin	NOUN
admet-2603	239	5	72	72	NUM
admet-2603	239	6	(	(	PUNCT
admet-2603	239	7	2024	2024	NUM
admet-2603	239	8	)	)	PUNCT
admet-2603	239	9	298	298	NUM
admet-2603	239	10	-	-	SYM
admet-2603	239	11	302	302	NUM
admet-2603	239	12	.	.	PUNCT
admet-2603	240	1	https://doi.org/10.1248/cpb.c23-00783	https://doi.org/10.1248/cpb.c23-00783	PROPN
admet-2603	240	2	[	[	X
admet-2603	240	3	25	25	NUM
admet-2603	240	4	]	]	PUNCT
admet-2603	240	5	m.	m.	NOUN
admet-2603	240	6	higashino	higashino	PROPN
admet-2603	240	7	,	,	PUNCT
admet-2603	240	8	k.	k.	PROPN
admet-2603	240	9	sugano	sugano	PROPN
admet-2603	240	10	.	.	PUNCT
admet-2603	241	1	comparison	comparison	NOUN
admet-2603	241	2	of	of	ADP
admet-2603	241	3	phosphate	phosphate	NOUN
admet-2603	241	4	and	and	CCONJ
admet-2603	241	5	bicarbonate	bicarbonate	NOUN
admet-2603	241	6	buffer	buffer	NOUN
admet-2603	241	7	solutions	solution	NOUN
admet-2603	241	8	as	as	ADP
admet-2603	241	9	dissolution	dissolution	NOUN
admet-2603	241	10	test	test	NOUN
admet-2603	241	11	media	medium	NOUN
admet-2603	241	12	for	for	ADP
admet-2603	241	13	predicting	predict	VERB
admet-2603	241	14	bioequivalence	bioequivalence	NOUN
admet-2603	241	15	of	of	ADP
admet-2603	241	16	febuxostat	febuxostat	NOUN
admet-2603	241	17	formulation	formulation	NOUN
admet-2603	241	18	.	.	PUNCT
admet-2603	242	1	chemical	chemical	NOUN
admet-2603	242	2	and	and	CCONJ
admet-2603	242	3	pharmaceutical	pharmaceutical	ADJ
admet-2603	242	4	bulletin	bulletin	NOUN
admet-2603	242	5	72	72	NUM
admet-2603	242	6	(	(	PUNCT
admet-2603	242	7	2024	2024	NUM
admet-2603	242	8	)	)	PUNCT
admet-2603	242	9	989	989	NUM
admet-2603	242	10	-	-	SYM
admet-2603	242	11	995	995	NUM
admet-2603	242	12	.	.	PUNCT
admet-2603	243	1	https://doi.org/10.1248/cpb.c24-00526	https://doi.org/10.1248/cpb.c24-00526	VERB
admet-2603	244	1	[	[	X
admet-2603	244	2	26	26	NUM
admet-2603	244	3	]	]	X
admet-2603	244	4	m.	m.	PROPN
admet-2603	244	5	kansy	kansy	PROPN
admet-2603	244	6	,	,	PUNCT
admet-2603	244	7	f.	f.	PROPN
admet-2603	244	8	senner	senner	PROPN
admet-2603	244	9	,	,	PUNCT
admet-2603	244	10	k.	k.	PROPN
admet-2603	244	11	gubernator	gubernator	PROPN
admet-2603	244	12	.	.	PUNCT
admet-2603	245	1	physicochemical	physicochemical	ADJ
admet-2603	245	2	high	high	ADJ
admet-2603	245	3	throughput	throughput	NOUN
admet-2603	245	4	screening	screening	NOUN
admet-2603	245	5	:	:	PUNCT
admet-2603	245	6	parallel	parallel	ADJ
admet-2603	245	7	artificial	artificial	ADJ
admet-2603	245	8	membrane	membrane	NOUN
admet-2603	245	9	permeation	permeation	NOUN
admet-2603	245	10	assay	assay	VERB
admet-2603	245	11	in	in	ADP
admet-2603	245	12	the	the	DET
admet-2603	245	13	description	description	NOUN
admet-2603	245	14	of	of	ADP
admet-2603	245	15	passive	passive	ADJ
admet-2603	245	16	absorption	absorption	NOUN
admet-2603	245	17	processes	process	NOUN
admet-2603	245	18	.	.	PUNCT
admet-2603	246	1	journal	journal	NOUN
admet-2603	246	2	of	of	ADP
admet-2603	246	3	medicinal	medicinal	ADJ
admet-2603	246	4	chemistry	chemistry	NOUN
admet-2603	246	5	41	41	NUM
admet-2603	246	6	(	(	PUNCT
admet-2603	246	7	1998	1998	NUM
admet-2603	246	8	)	)	PUNCT
admet-2603	246	9	1007	1007	NUM
admet-2603	246	10	-	-	SYM
admet-2603	246	11	1010	1010	NUM
admet-2603	246	12	.	.	PUNCT
admet-2603	247	1	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	PROPN
admet-2603	247	2	https://doi.org/10.1016/j.ejps.2022.106326	https://doi.org/10.1016/j.ejps.2022.106326	PROPN
admet-2603	247	3	https://doi.org/10.1021/acs.molpharmaceut.9b00187	https://doi.org/10.1021/acs.molpharmaceut.9b00187	PROPN
admet-2603	247	4	https://doi.org/10.1002/jps.24460	https://doi.org/10.1002/jps.24460	ADJ
admet-2603	247	5	https://doi.org/10.1021/mp800148u	https://doi.org/10.1021/mp800148u	NOUN
admet-2603	247	6	https://doi.org/10.1016/j.ejpb.2021.09.009	https://doi.org/10.1016/j.ejpb.2021.09.009	PROPN
admet-2603	247	7	https://doi.org/10.1007/s11095-023-03508-x	https://doi.org/10.1007/s11095-023-03508-x	PROPN
admet-2603	247	8	https://doi.org/10.1021/acs.molpharmaceut.4c00028	https://doi.org/10.1021/acs.molpharmaceut.4c00028	ADP
admet-2603	247	9	https://doi.org/10.1021/acs.molpharmaceut.8b00783	https://doi.org/10.1021/acs.molpharmaceut.8b00783	NUM
admet-2603	247	10	https://doi.org/10.1016/j.xphs.2024.10.025	https://doi.org/10.1016/j.xphs.2024.10.025	PROPN
admet-2603	247	11	https://doi.org/10.1016/j.dmpk.2023.100519	https://doi.org/10.1016/j.dmpk.2023.100519	PROPN
admet-2603	247	12	https://doi.org/10.1007/s11095-024-03701-6	https://doi.org/10.1007/s11095-024-03701-6	NUM
admet-2603	247	13	https://doi.org/10.1007/s11095-024-03701-6	https://doi.org/10.1007/s11095-024-03701-6	NUM
admet-2603	248	1	https://doi.org/10.1016/j.ejps.2023.106622	https://doi.org/10.1016/j.ejps.2023.106622	PROPN
admet-2603	248	2	https://doi.org/10.1248/cpb.c23-00783	https://doi.org/10.1248/cpb.c23-00783	PROPN
admet-2603	248	3	https://doi.org/10.1248/cpb.c24-00526	https://doi.org/10.1248/cpb.c24-00526	PROPN
admet-2603	248	4	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	PROPN
admet-2603	248	5	admet	admet	PROPN
admet-2603	248	6	&	&	CCONJ
admet-2603	248	7	dmpk	dmpk	PROPN
admet-2603	248	8	13(1	13(1	NUM
admet-2603	248	9	)	)	PUNCT
admet-2603	248	10	(	(	PUNCT
admet-2603	248	11	2025	2025	NUM
admet-2603	248	12	)	)	PUNCT
admet-2603	248	13	2603	2603	NUM
admet-2603	248	14	effect	effect	NOUN
admet-2603	248	15	of	of	ADP
admet-2603	248	16	bicarbonate	bicarbonate	NOUN
admet-2603	248	17	buffer	buffer	NOUN
admet-2603	248	18	on	on	ADP
admet-2603	248	19	artificial	artificial	ADJ
admet-2603	248	20	membrane	membrane	NOUN
admet-2603	248	21	permeation	permeation	NOUN
admet-2603	248	22	of	of	ADP
admet-2603	248	23	drugs	drug	NOUN
admet-2603	248	24	doi	doi	PROPN
admet-2603	248	25	:	:	PUNCT
admet-2603	248	26	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	NOUN
admet-2603	248	27	9	9	NUM
admet-2603	248	28	[	[	SYM
admet-2603	248	29	27	27	NUM
admet-2603	248	30	]	]	PUNCT
admet-2603	248	31	k.	k.	PROPN
admet-2603	248	32	sugano	sugano	PROPN
admet-2603	248	33	,	,	PUNCT
admet-2603	248	34	m.	m.	PROPN
admet-2603	248	35	kansy	kansy	PROPN
admet-2603	248	36	,	,	PUNCT
admet-2603	248	37	p.	p.	PROPN
admet-2603	248	38	artursson	artursson	PROPN
admet-2603	248	39	,	,	PUNCT
admet-2603	248	40	a.	a.	PROPN
admet-2603	248	41	avdeef	avdeef	PROPN
admet-2603	248	42	,	,	PUNCT
admet-2603	248	43	s.	s.	PROPN
admet-2603	248	44	bendels	bendels	PROPN
admet-2603	248	45	,	,	PUNCT
admet-2603	248	46	l.	l.	PROPN
admet-2603	248	47	di	di	PROPN
admet-2603	248	48	,	,	PUNCT
admet-2603	248	49	g.f	g.f	PROPN
admet-2603	248	50	.	.	PROPN
admet-2603	248	51	ecker	ecker	PROPN
admet-2603	248	52	,	,	PUNCT
admet-2603	248	53	b.	b.	PROPN
admet-2603	248	54	faller	faller	PROPN
admet-2603	248	55	,	,	PUNCT
admet-2603	248	56	h.	h.	PROPN
admet-2603	248	57	fischer	fischer	PROPN
admet-2603	248	58	,	,	PUNCT
admet-2603	248	59	g.	g.	PROPN
admet-2603	248	60	gerebtzoff	gerebtzoff	PROPN
admet-2603	248	61	,	,	PUNCT
admet-2603	248	62	h.	h.	PROPN
admet-2603	248	63	lennernaes	lennernaes	PROPN
admet-2603	248	64	,	,	PUNCT
admet-2603	248	65	f.	f.	PROPN
admet-2603	248	66	senner	senner	PROPN
admet-2603	248	67	.	.	PUNCT
admet-2603	249	1	coexistence	coexistence	NOUN
admet-2603	249	2	of	of	ADP
admet-2603	249	3	passive	passive	ADJ
admet-2603	249	4	and	and	CCONJ
admet-2603	249	5	carrier	carrier	NOUN
admet-2603	249	6	-	-	PUNCT
admet-2603	249	7	mediated	mediate	VERB
admet-2603	249	8	processes	process	NOUN
admet-2603	249	9	in	in	ADP
admet-2603	249	10	drug	drug	NOUN
admet-2603	249	11	transport	transport	NOUN
admet-2603	249	12	.	.	PUNCT
admet-2603	250	1	nature	nature	NOUN
admet-2603	250	2	reviews	review	VERB
admet-2603	250	3	drug	drug	NOUN
admet-2603	250	4	discovery	discovery	NOUN
admet-2603	250	5	9	9	NUM
admet-2603	250	6	(	(	PUNCT
admet-2603	250	7	2010	2010	NUM
admet-2603	250	8	)	)	PUNCT
admet-2603	250	9	597	597	NUM
admet-2603	250	10	-	-	SYM
admet-2603	250	11	614	614	NUM
admet-2603	250	12	.	.	PUNCT
admet-2603	250	13	https://doi.org/10.1038/nrd3187	https://doi.org/10.1038/nrd3187	PROPN
admet-2603	251	1	[	[	X
admet-2603	251	2	28	28	NUM
admet-2603	251	3	]	]	X
admet-2603	251	4	n.	n.	PROPN
admet-2603	251	5	sun	sun	PROPN
admet-2603	251	6	,	,	PUNCT
admet-2603	251	7	a.	a.	NOUN
admet-2603	251	8	avdeef	avdeef	PROPN
admet-2603	251	9	.	.	PUNCT
admet-2603	252	1	biorelevant	biorelevant	PROPN
admet-2603	252	2	pk	pk	PROPN
admet-2603	252	3	a	a	X
admet-2603	252	4	(	(	PUNCT
admet-2603	252	5	37	37	NUM
admet-2603	252	6	°	°	NOUN
admet-2603	252	7	c	c	NOUN
admet-2603	252	8	)	)	PUNCT
admet-2603	252	9	predicted	predict	VERB
admet-2603	252	10	from	from	ADP
admet-2603	252	11	the	the	DET
admet-2603	252	12	2d	2d	NUM
admet-2603	252	13	structure	structure	NOUN
admet-2603	252	14	of	of	ADP
admet-2603	252	15	the	the	DET
admet-2603	252	16	molecule	molecule	NOUN
admet-2603	252	17	and	and	CCONJ
admet-2603	252	18	its	its	PRON
admet-2603	252	19	pk	pk	NOUN
admet-2603	252	20	a	a	PRON
admet-2603	252	21	at	at	ADP
admet-2603	252	22	25	25	NUM
admet-2603	252	23	°	°	NOUN
admet-2603	252	24	c	c	NOUN
admet-2603	252	25	.	.	PUNCT
admet-2603	253	1	journal	journal	PROPN
admet-2603	253	2	of	of	ADP
admet-2603	253	3	pharmaceutical	pharmaceutical	NOUN
admet-2603	253	4	and	and	CCONJ
admet-2603	253	5	biomedical	biomedical	ADJ
admet-2603	253	6	analysis	analysis	NOUN
admet-2603	253	7	56	56	NUM
admet-2603	253	8	(	(	PUNCT
admet-2603	253	9	2011	2011	NUM
admet-2603	253	10	)	)	PUNCT
admet-2603	253	11	173	173	NUM
admet-2603	253	12	-	-	SYM
admet-2603	253	13	182	182	NUM
admet-2603	253	14	.	.	PUNCT
admet-2603	254	1	https://doi.org/10.1016/j.jpba.2011.05.007	https://doi.org/10.1016/j.jpba.2011.05.007	VERB
admet-2603	254	2	[	[	X
admet-2603	254	3	29	29	NUM
admet-2603	254	4	]	]	PUNCT
admet-2603	254	5	a.	a.	NOUN
admet-2603	254	6	avdeef	avdeef	PROPN
admet-2603	254	7	.	.	PUNCT
admet-2603	255	1	leakiness	leakiness	NOUN
admet-2603	255	2	and	and	CCONJ
admet-2603	255	3	size	size	NOUN
admet-2603	255	4	exclusion	exclusion	NOUN
admet-2603	255	5	of	of	ADP
admet-2603	255	6	paracellular	paracellular	ADJ
admet-2603	255	7	channels	channel	NOUN
admet-2603	255	8	in	in	ADP
admet-2603	255	9	cultured	cultured	ADJ
admet-2603	255	10	epithelial	epithelial	ADJ
admet-2603	255	11	cell	cell	NOUN
admet-2603	255	12	monolayers	monolayer	NOUN
admet-2603	255	13	-	-	ADJ
admet-2603	255	14	interlaboratory	interlaboratory	ADJ
admet-2603	255	15	comparison	comparison	NOUN
admet-2603	255	16	.	.	PUNCT
admet-2603	256	1	pharmaceutical	pharmaceutical	ADJ
admet-2603	256	2	research	research	NOUN
admet-2603	256	3	27	27	NUM
admet-2603	256	4	(	(	PUNCT
admet-2603	256	5	2010	2010	NUM
admet-2603	256	6	)	)	PUNCT
admet-2603	256	7	480	480	NUM
admet-2603	256	8	-	-	SYM
admet-2603	256	9	489	489	NUM
admet-2603	256	10	.	.	PUNCT
admet-2603	257	1	https://doi.org/10.1007/s11095-009-0036-7	https://doi.org/10.1007/s11095-009-0036-7	PRON
admet-2603	258	1	[	[	X
admet-2603	258	2	30	30	NUM
admet-2603	258	3	]	]	PUNCT
admet-2603	258	4	s.	s.	PROPN
admet-2603	258	5	yamauchi	yamauchi	PROPN
admet-2603	258	6	,	,	PUNCT
admet-2603	258	7	k.	k.	PROPN
admet-2603	258	8	sugano	sugano	PROPN
admet-2603	258	9	.	.	PUNCT
admet-2603	259	1	permeation	permeation	NOUN
admet-2603	259	2	characteristics	characteristic	NOUN
admet-2603	259	3	of	of	ADP
admet-2603	259	4	tetracyclines	tetracycline	NOUN
admet-2603	259	5	in	in	ADP
admet-2603	259	6	parallel	parallel	ADJ
admet-2603	259	7	artificial	artificial	ADJ
admet-2603	259	8	membrane	membrane	NOUN
admet-2603	259	9	permeation	permeation	NOUN
admet-2603	259	10	assay	assay	VERB
admet-2603	259	11	.	.	PUNCT
admet-2603	260	1	admet	admet	PROPN
admet-2603	260	2	and	and	CCONJ
admet-2603	260	3	dmpk	dmpk	VERB
admet-2603	260	4	7	7	NUM
admet-2603	260	5	(	(	PUNCT
admet-2603	260	6	2019	2019	NUM
admet-2603	260	7	)	)	PUNCT
admet-2603	260	8	151	151	NUM
admet-2603	260	9	-	-	SYM
admet-2603	260	10	160	160	NUM
admet-2603	260	11	.	.	PUNCT
admet-2603	260	12	https://doi.org/10.5599/admet.657	https://doi.org/10.5599/admet.657	X
admet-2603	261	1	[	[	X
admet-2603	261	2	31	31	NUM
admet-2603	261	3	]	]	X
admet-2603	261	4	e.t	e.t	PROPN
admet-2603	261	5	.	.	PROPN
admet-2603	261	6	urbansky	urbansky	PROPN
admet-2603	261	7	,	,	PUNCT
admet-2603	261	8	m.r	m.r	PROPN
admet-2603	261	9	.	.	PROPN
admet-2603	261	10	schock	schock	PROPN
admet-2603	261	11	.	.	PUNCT
admet-2603	262	1	understanding	understanding	NOUN
admet-2603	262	2	,	,	PUNCT
admet-2603	262	3	deriving	deriving	NOUN
admet-2603	262	4	,	,	PUNCT
admet-2603	262	5	and	and	CCONJ
admet-2603	262	6	computing	computing	NOUN
admet-2603	262	7	buffer	buffer	NOUN
admet-2603	262	8	capacity	capacity	NOUN
admet-2603	262	9	.	.	PUNCT
admet-2603	263	1	journal	journal	NOUN
admet-2603	263	2	of	of	ADP
admet-2603	263	3	chemical	chemical	ADJ
admet-2603	263	4	education	education	NOUN
admet-2603	263	5	77	77	NUM
admet-2603	263	6	(	(	PUNCT
admet-2603	263	7	2009	2009	NUM
admet-2603	263	8	)	)	PUNCT
admet-2603	263	9	1640	1640	NUM
admet-2603	263	10	.	.	PUNCT
admet-2603	264	1	https://doi.org/10.1021/ed077p1640	https://doi.org/10.1021/ed077p1640	PROPN
admet-2603	264	2	[	[	X
admet-2603	265	1	32	32	NUM
admet-2603	265	2	]	]	PUNCT
admet-2603	265	3	k.	k.	PROPN
admet-2603	265	4	sugano	sugano	PROPN
admet-2603	265	5	,	,	PUNCT
admet-2603	265	6	y.	y.	PROPN
admet-2603	265	7	nabuchi	nabuchi	PROPN
admet-2603	265	8	,	,	PUNCT
admet-2603	265	9	m.	m.	PROPN
admet-2603	265	10	machida	machida	PROPN
admet-2603	265	11	,	,	PUNCT
admet-2603	265	12	y.	y.	PROPN
admet-2603	265	13	asoh	asoh	PROPN
admet-2603	265	14	.	.	PUNCT
admet-2603	266	1	permeation	permeation	NOUN
admet-2603	266	2	characteristics	characteristic	NOUN
admet-2603	266	3	of	of	ADP
admet-2603	266	4	a	a	DET
admet-2603	266	5	hydrophilic	hydrophilic	ADJ
admet-2603	266	6	basic	basic	ADJ
admet-2603	266	7	compound	compound	NOUN
admet-2603	266	8	across	across	ADP
admet-2603	266	9	a	a	DET
admet-2603	266	10	bio	bio	ADJ
admet-2603	266	11	-	-	ADJ
admet-2603	266	12	mimetic	mimetic	ADJ
admet-2603	266	13	artificial	artificial	ADJ
admet-2603	266	14	membrane	membrane	NOUN
admet-2603	266	15	.	.	PUNCT
admet-2603	267	1	international	international	ADJ
admet-2603	267	2	journal	journal	PROPN
admet-2603	267	3	of	of	ADP
admet-2603	267	4	pharmaceutics	pharmaceutic	NOUN
admet-2603	267	5	275	275	NUM
admet-2603	267	6	(	(	PUNCT
admet-2603	267	7	2004	2004	NUM
admet-2603	267	8	)	)	PUNCT
admet-2603	267	9	271	271	NUM
admet-2603	267	10	-	-	SYM
admet-2603	267	11	278	278	NUM
admet-2603	267	12	.	.	PUNCT
admet-2603	268	1	https://doi.org/10.1016/j.ijpharm.2004.02.010	https://doi.org/10.1016/j.ijpharm.2004.02.010	NOUN
admet-2603	269	1	[	[	X
admet-2603	269	2	33	33	NUM
admet-2603	269	3	]	]	X
admet-2603	269	4	z.s	z.s	PROPN
admet-2603	269	5	.	.	PROPN
admet-2603	269	6	teksin	teksin	PROPN
admet-2603	269	7	,	,	PUNCT
admet-2603	269	8	k.	k.	PROPN
admet-2603	269	9	hom	hom	PROPN
admet-2603	269	10	,	,	PUNCT
admet-2603	269	11	a.	a.	PROPN
admet-2603	269	12	balakrishnan	balakrishnan	PROPN
admet-2603	269	13	,	,	PUNCT
admet-2603	269	14	j.e	j.e	PROPN
admet-2603	269	15	.	.	PROPN
admet-2603	269	16	polli	polli	PROPN
admet-2603	269	17	.	.	PUNCT
admet-2603	270	1	ion	ion	NOUN
admet-2603	270	2	pair	pair	NOUN
admet-2603	270	3	-	-	PUNCT
admet-2603	270	4	mediated	mediate	VERB
admet-2603	270	5	transport	transport	NOUN
admet-2603	270	6	of	of	ADP
admet-2603	270	7	metoprolol	metoprolol	PROPN
admet-2603	270	8	across	across	ADP
admet-2603	270	9	a	a	DET
admet-2603	270	10	three	three	NUM
admet-2603	270	11	lipid	lipid	NOUN
admet-2603	270	12	-	-	PUNCT
admet-2603	270	13	component	component	NOUN
admet-2603	270	14	pampa	pampa	NOUN
admet-2603	270	15	system	system	NOUN
admet-2603	270	16	.	.	PUNCT
admet-2603	271	1	journal	journal	PROPN
admet-2603	271	2	of	of	ADP
admet-2603	271	3	controlled	control	VERB
admet-2603	271	4	release	release	NOUN
admet-2603	271	5	116	116	NUM
admet-2603	271	6	(	(	PUNCT
admet-2603	271	7	2006	2006	NUM
admet-2603	271	8	)	)	PUNCT
admet-2603	271	9	50	50	NUM
admet-2603	271	10	-	-	SYM
admet-2603	271	11	57	57	NUM
admet-2603	271	12	.	.	PUNCT
admet-2603	272	1	https://doi.org/10.1016/j.jconrel.2006.08.020	https://doi.org/10.1016/j.jconrel.2006.08.020	NOUN
admet-2603	272	2	[	[	PUNCT
admet-2603	272	3	34	34	NUM
admet-2603	272	4	]	]	X
admet-2603	272	5	y.f	y.f	PROPN
admet-2603	272	6	.	.	PROPN
admet-2603	272	7	shiau	shiau	PROPN
admet-2603	272	8	,	,	PUNCT
admet-2603	272	9	p.	p.	PROPN
admet-2603	272	10	fernandez	fernandez	PROPN
admet-2603	272	11	,	,	PUNCT
admet-2603	272	12	m.j	m.j	PROPN
admet-2603	272	13	.	.	PROPN
admet-2603	272	14	jackson	jackson	PROPN
admet-2603	272	15	,	,	PUNCT
admet-2603	272	16	s.	s.	PROPN
admet-2603	272	17	mcmonagle	mcmonagle	PROPN
admet-2603	272	18	.	.	PUNCT
admet-2603	273	1	mechanisms	mechanism	NOUN
admet-2603	273	2	maintaining	maintain	VERB
admet-2603	273	3	a	a	DET
admet-2603	273	4	low	low	ADJ
admet-2603	273	5	-	-	PUNCT
admet-2603	273	6	ph	ph	NOUN
admet-2603	273	7	microclimate	microclimate	NOUN
admet-2603	273	8	in	in	ADP
admet-2603	273	9	the	the	DET
admet-2603	273	10	intestine	intestine	NOUN
admet-2603	273	11	.	.	PUNCT
admet-2603	274	1	american	american	ADJ
admet-2603	274	2	journal	journal	PROPN
admet-2603	274	3	of	of	ADP
admet-2603	274	4	physiology	physiology	NOUN
admet-2603	274	5	-	-	PUNCT
admet-2603	274	6	gastrointestinal	gastrointestinal	ADJ
admet-2603	274	7	and	and	CCONJ
admet-2603	274	8	liver	liver	NOUN
admet-2603	274	9	physiology	physiology	NOUN
admet-2603	274	10	248	248	NUM
admet-2603	274	11	(	(	PUNCT
admet-2603	274	12	1985	1985	NUM
admet-2603	274	13	)	)	PUNCT
admet-2603	274	14	g608	g608	PROPN
admet-2603	274	15	-	-	PUNCT
admet-2603	274	16	g617	g617	PROPN
admet-2603	274	17	.	.	PUNCT
admet-2603	275	1	https://doi.org/10.1152/ajpgi.1985.248.6.g608	https://doi.org/10.1152/ajpgi.1985.248.6.g608	PRON
admet-2603	276	1	[	[	X
admet-2603	276	2	35	35	NUM
admet-2603	276	3	]	]	X
admet-2603	276	4	k.g	k.g	PROPN
admet-2603	276	5	.	.	PROPN
admet-2603	276	6	mooney	mooney	PROPN
admet-2603	276	7	,	,	PUNCT
admet-2603	276	8	m.a	m.a	PROPN
admet-2603	276	9	.	.	PROPN
admet-2603	276	10	mintun	mintun	PROPN
admet-2603	276	11	,	,	PUNCT
admet-2603	276	12	k.j	k.j	PROPN
admet-2603	276	13	.	.	PROPN
admet-2603	276	14	himmelstein	himmelstein	PROPN
admet-2603	276	15	,	,	PUNCT
admet-2603	276	16	v.j	v.j	PROPN
admet-2603	276	17	.	.	PROPN
admet-2603	276	18	stella	stella	PROPN
admet-2603	276	19	.	.	PUNCT
admet-2603	277	1	dissolution	dissolution	PROPN
admet-2603	277	2	kinetics	kinetic	NOUN
admet-2603	277	3	of	of	ADP
admet-2603	277	4	carboxylic	carboxylic	ADJ
admet-2603	277	5	acids	acid	NOUN
admet-2603	277	6	ii	ii	NOUN
admet-2603	277	7	:	:	PUNCT
admet-2603	277	8	effect	effect	NOUN
admet-2603	277	9	of	of	ADP
admet-2603	277	10	buffers	buffer	NOUN
admet-2603	277	11	.	.	PUNCT
admet-2603	278	1	journal	journal	PROPN
admet-2603	278	2	of	of	ADP
admet-2603	278	3	pharmaceutical	pharmaceutical	PROPN
admet-2603	278	4	sciences	science	NOUN
admet-2603	278	5	70	70	NUM
admet-2603	278	6	(	(	PUNCT
admet-2603	278	7	1981	1981	NUM
admet-2603	278	8	)	)	PUNCT
admet-2603	278	9	22	22	NUM
admet-2603	278	10	-	-	SYM
admet-2603	278	11	32	32	NUM
admet-2603	278	12	.	.	PUNCT
admet-2603	279	1	https://doi.org/10.1002/jps.2600700104	https://doi.org/10.1002/jps.2600700104	NOUN
admet-2603	280	1	[	[	X
admet-2603	280	2	36	36	NUM
admet-2603	280	3	]	]	X
admet-2603	280	4	s.s	s.s	PROPN
admet-2603	280	5	.	.	PROPN
admet-2603	280	6	ozturk	ozturk	PROPN
admet-2603	280	7	,	,	PUNCT
admet-2603	280	8	b.o	b.o	PROPN
admet-2603	280	9	.	.	PROPN
admet-2603	280	10	palsson	palsson	PROPN
admet-2603	280	11	,	,	PUNCT
admet-2603	281	1	j.b	j.b	PROPN
admet-2603	281	2	.	.	PROPN
admet-2603	281	3	dressman	dressman	PROPN
admet-2603	281	4	.	.	PUNCT
admet-2603	282	1	dissolution	dissolution	PROPN
admet-2603	282	2	of	of	ADP
admet-2603	282	3	lonizable	lonizable	ADJ
admet-2603	282	4	drugs	drug	NOUN
admet-2603	282	5	in	in	ADP
admet-2603	282	6	buffered	buffered	ADJ
admet-2603	282	7	and	and	CCONJ
admet-2603	282	8	unbuffered	unbuffered	ADJ
admet-2603	282	9	solutions	solution	NOUN
admet-2603	282	10	.	.	PUNCT
admet-2603	283	1	pharmaceutical	pharmaceutical	ADJ
admet-2603	283	2	research	research	NOUN
admet-2603	283	3	5	5	NUM
admet-2603	283	4	(	(	PUNCT
admet-2603	283	5	1988	1988	NUM
admet-2603	283	6	)	)	PUNCT
admet-2603	283	7	272	272	NUM
admet-2603	283	8	-	-	SYM
admet-2603	283	9	282	282	NUM
admet-2603	283	10	.	.	PUNCT
admet-2603	284	1	https://doi.org/10.1023/a:1015970502993	https://doi.org/10.1023/a:1015970502993	PRON
admet-2603	285	1	[	[	X
admet-2603	285	2	37	37	NUM
admet-2603	285	3	]	]	PUNCT
admet-2603	285	4	a.	a.	NOUN
admet-2603	285	5	avdeef	avdeef	PROPN
admet-2603	285	6	,	,	PUNCT
admet-2603	285	7	o.	o.	PROPN
admet-2603	285	8	tsinman	tsinman	NOUN
admet-2603	285	9	.	.	PUNCT
admet-2603	286	1	miniaturized	miniaturize	VERB
admet-2603	286	2	rotating	rotating	NOUN
admet-2603	286	3	disk	disk	NOUN
admet-2603	286	4	intrinsic	intrinsic	ADJ
admet-2603	286	5	dissolution	dissolution	NOUN
admet-2603	286	6	rate	rate	NOUN
admet-2603	286	7	measurement	measurement	NOUN
admet-2603	286	8	:	:	PUNCT
admet-2603	286	9	effects	effect	NOUN
admet-2603	286	10	of	of	ADP
admet-2603	286	11	buffer	buffer	NOUN
admet-2603	286	12	capacity	capacity	NOUN
admet-2603	286	13	in	in	ADP
admet-2603	286	14	comparisons	comparison	NOUN
admet-2603	286	15	to	to	ADP
admet-2603	286	16	traditional	traditional	ADJ
admet-2603	286	17	wood	wood	NOUN
admet-2603	286	18	’s	’s	PART
admet-2603	286	19	apparatus	apparatus	NOUN
admet-2603	286	20	.	.	PUNCT
admet-2603	287	1	pharmaceutical	pharmaceutical	PROPN
admet-2603	287	2	research	research	NOUN
admet-2603	287	3	25	25	NUM
admet-2603	287	4	(	(	PUNCT
admet-2603	287	5	2008	2008	NUM
admet-2603	287	6	)	)	PUNCT
admet-2603	287	7	2613	2613	NUM
admet-2603	287	8	-	-	SYM
admet-2603	287	9	2627	2627	NUM
admet-2603	287	10	.	.	PUNCT
admet-2603	288	1	https://doi.org/10.1007/s11095-008-9679-z	https://doi.org/10.1007/s11095-008-9679-z	PROPN
admet-2603	288	2	.	.	PUNCT
admet-2603	289	1	©	©	PROPN
admet-2603	289	2	2025	2025	NUM
admet-2603	289	3	by	by	ADP
admet-2603	289	4	the	the	DET
admet-2603	289	5	authors	author	NOUN
admet-2603	289	6	;	;	PUNCT
admet-2603	289	7	licensee	licensee	PROPN
admet-2603	289	8	iapc	iapc	PROPN
admet-2603	289	9	,	,	PUNCT
admet-2603	289	10	zagreb	zagreb	PROPN
admet-2603	289	11	,	,	PUNCT
admet-2603	289	12	croatia	croatia	PROPN
admet-2603	289	13	.	.	PUNCT
admet-2603	290	1	this	this	DET
admet-2603	290	2	article	article	NOUN
admet-2603	290	3	is	be	AUX
admet-2603	290	4	an	an	DET
admet-2603	290	5	open	open	ADJ
admet-2603	290	6	-	-	PUNCT
admet-2603	290	7	access	access	NOUN
admet-2603	290	8	article	article	NOUN
admet-2603	290	9	distributed	distribute	VERB
admet-2603	290	10	under	under	ADP
admet-2603	290	11	the	the	DET
admet-2603	290	12	terms	term	NOUN
admet-2603	290	13	and	and	CCONJ
admet-2603	290	14	conditions	condition	NOUN
admet-2603	290	15	of	of	ADP
admet-2603	290	16	the	the	DET
admet-2603	290	17	creative	creative	ADJ
admet-2603	290	18	commons	common	NOUN
admet-2603	290	19	attribution	attribution	NOUN
admet-2603	290	20	license	license	NOUN
admet-2603	290	21	(	(	PUNCT
admet-2603	290	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2603	290	23	)	)	PUNCT
admet-2603	290	24	https://doi.org/10.5599/admet.2603	https://doi.org/10.5599/admet.2603	PROPN
admet-2603	290	25	https://doi.org/10.1038/nrd3187	https://doi.org/10.1038/nrd3187	VERB
admet-2603	290	26	https://doi.org/10.1016/j.jpba.2011.05.007	https://doi.org/10.1016/j.jpba.2011.05.007	NUM
admet-2603	290	27	https://doi.org/10.1007/s11095-009-0036-7	https://doi.org/10.1007/s11095-009-0036-7	NUM
admet-2603	290	28	https://doi.org/10.5599/admet.657	https://doi.org/10.5599/admet.657	NOUN
admet-2603	290	29	https://doi.org/10.1021/ed077p1640	https://doi.org/10.1021/ed077p1640	VERB
admet-2603	291	1	https://doi.org/10.1016/j.ijpharm.2004.02.010	https://doi.org/10.1016/j.ijpharm.2004.02.010	PROPN
admet-2603	291	2	https://doi.org/10.1016/j.jconrel.2006.08.020	https://doi.org/10.1016/j.jconrel.2006.08.020	PROPN
admet-2603	291	3	https://doi.org/10.1152/ajpgi.1985.248.6.g608	https://doi.org/10.1152/ajpgi.1985.248.6.g608	NOUN
admet-2603	291	4	https://doi.org/10.1002/jps.2600700104	https://doi.org/10.1002/jps.2600700104	NOUN
admet-2603	291	5	https://doi.org/10.1023/a:1015970502993	https://doi.org/10.1023/a:1015970502993	PROPN
admet-2603	291	6	https://doi.org/10.1007/s11095-008-9679-z	https://doi.org/10.1007/s11095-008-9679-z	PROPN
admet-2603	291	7	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN