id	sid	tid	token	lemma	pos
admet-2626	1	1	often	often	ADV
admet-2626	1	2	neglected	neglect	VERB
admet-2626	1	3	steps	step	NOUN
admet-2626	1	4	in	in	ADP
admet-2626	1	5	transforming	transform	VERB
admet-2626	1	6	drug	drug	NOUN
admet-2626	1	7	solubility	solubility	NOUN
admet-2626	1	8	from	from	ADP
admet-2626	1	9	single	single	ADJ
admet-2626	1	10	measurement	measurement	NOUN
admet-2626	1	11	in	in	ADP
admet-2626	1	12	pure	pure	ADJ
admet-2626	1	13	water	water	NOUN
admet-2626	1	14	to	to	ADP
admet-2626	1	15	physiologically	physiologically	ADV
admet-2626	1	16	-	-	PUNCT
admet-2626	1	17	appropriate	appropriate	ADJ
admet-2626	1	18	solubility	solubility	NOUN
admet-2626	1	19	-	-	PUNCT
admet-2626	1	20	ph	ph	ADJ
admet-2626	1	21	doi	doi	NOUN
admet-2626	1	22	:	:	PUNCT
admet-2626	1	23	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	1	24	1	1	NUM
admet-2626	1	25	admet	admet	X
admet-2626	1	26	&	&	CCONJ
admet-2626	1	27	dmpk	dmpk	PROPN
admet-2626	1	28	13(1	13(1	NUM
admet-2626	1	29	)	)	PUNCT
admet-2626	1	30	(	(	PUNCT
admet-2626	1	31	2025	2025	NUM
admet-2626	1	32	)	)	PUNCT
admet-2626	1	33	2626	2626	NUM
admet-2626	1	34	;	;	PUNCT
admet-2626	1	35	doi	doi	NOUN
admet-2626	1	36	:	:	PUNCT
admet-2626	1	37	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	1	38	open	open	ADJ
admet-2626	1	39	access	access	NOUN
admet-2626	1	40	:	:	PUNCT
admet-2626	1	41	issn	issn	PROPN
admet-2626	1	42	:	:	PUNCT
admet-2626	1	43	1848	1848	NUM
admet-2626	1	44	-	-	SYM
admet-2626	1	45	7718	7718	NUM
admet-2626	1	46	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2626	1	47	commentary	commentary	NOUN
admet-2626	1	48	often	often	ADV
admet-2626	1	49	neglected	neglect	VERB
admet-2626	1	50	steps	step	NOUN
admet-2626	1	51	in	in	ADP
admet-2626	1	52	transforming	transform	VERB
admet-2626	1	53	drug	drug	NOUN
admet-2626	1	54	solubility	solubility	NOUN
admet-2626	1	55	from	from	ADP
admet-2626	1	56	single	single	ADJ
admet-2626	1	57	measurement	measurement	NOUN
admet-2626	1	58	in	in	ADP
admet-2626	1	59	pure	pure	ADJ
admet-2626	1	60	water	water	NOUN
admet-2626	1	61	to	to	ADP
admet-2626	1	62	physiologically	physiologically	ADV
admet-2626	1	63	-	-	PUNCT
admet-2626	1	64	appropriate	appropriate	ADJ
admet-2626	1	65	solubility	solubility	NOUN
admet-2626	1	66	-	-	PUNCT
admet-2626	1	67	ph	ph	NOUN
admet-2626	1	68	alex	alex	PROPN
admet-2626	1	69	avdeef	avdeef	PROPN
admet-2626	1	70	in	in	ADP
admet-2626	1	71	-	-	PUNCT
admet-2626	1	72	adme	adme	NOUN
admet-2626	1	73	research	research	NOUN
admet-2626	1	74	,	,	PUNCT
admet-2626	1	75	new	new	PROPN
admet-2626	1	76	york	york	PROPN
admet-2626	1	77	city	city	PROPN
admet-2626	1	78	,	,	PUNCT
admet-2626	1	79	ny	ny	PROPN
admet-2626	1	80	10128	10128	NUM
admet-2626	1	81	,	,	PUNCT
admet-2626	1	82	usa	usa	PROPN
admet-2626	1	83	e	e	PROPN
admet-2626	1	84	-	-	NOUN
admet-2626	1	85	mail	mail	NOUN
admet-2626	1	86	:	:	PUNCT
admet-2626	1	87	alex@in-adme.com	alex@in-adme.com	NOUN
admet-2626	1	88	;	;	PUNCT
admet-2626	1	89	tel	tel	ADP
admet-2626	1	90	:	:	PUNCT
admet-2626	1	91	+1	+1	PROPN
admet-2626	1	92	6466785713	6466785713	NUM
admet-2626	1	93	received	receive	VERB
admet-2626	1	94	:	:	PUNCT
admet-2626	1	95	january	january	PROPN
admet-2626	1	96	3	3	NUM
admet-2626	1	97	,	,	PUNCT
admet-2626	1	98	2025	2025	NUM
admet-2626	1	99	;	;	PUNCT
admet-2626	1	100	revised	revise	VERB
admet-2626	1	101	:	:	PUNCT
admet-2626	1	102	february	february	PROPN
admet-2626	1	103	21	21	NUM
admet-2626	1	104	,	,	PUNCT
admet-2626	1	105	2025	2025	NUM
admet-2626	1	106	;	;	PUNCT
admet-2626	1	107	published	publish	VERB
admet-2626	1	108	:	:	PUNCT
admet-2626	1	109	february	february	PROPN
admet-2626	1	110	26	26	NUM
admet-2626	1	111	,	,	PUNCT
admet-2626	1	112	2025	2025	NUM
admet-2626	1	113	abstract	abstract	ADJ
admet-2626	1	114	background	background	NOUN
admet-2626	1	115	and	and	CCONJ
admet-2626	1	116	purpose	purpose	NOUN
admet-2626	1	117	:	:	PUNCT
admet-2626	1	118	the	the	DET
admet-2626	1	119	solubility	solubility	NOUN
admet-2626	1	120	of	of	ADP
admet-2626	1	121	weakly	weakly	ADJ
admet-2626	1	122	-	-	PUNCT
admet-2626	1	123	ionizable	ionizable	ADJ
admet-2626	1	124	drugs	drug	NOUN
admet-2626	1	125	in	in	ADP
admet-2626	1	126	pure	pure	ADJ
admet-2626	1	127	water	water	NOUN
admet-2626	1	128	,	,	PUNCT
admet-2626	1	129	sw	sw	PROPN
admet-2626	1	130	,	,	PUNCT
admet-2626	1	131	is	be	AUX
admet-2626	1	132	commonly	commonly	ADV
admet-2626	1	133	measured	measure	VERB
admet-2626	1	134	.	.	PUNCT
admet-2626	2	1	the	the	DET
admet-2626	2	2	ph	ph	ADJ
admet-2626	2	3	-	-	ADJ
admet-2626	2	4	dependent	dependent	ADJ
admet-2626	2	5	properties	property	NOUN
admet-2626	2	6	of	of	ADP
admet-2626	2	7	the	the	DET
admet-2626	2	8	saturated	saturate	VERB
admet-2626	2	9	solutions	solution	NOUN
admet-2626	2	10	can	can	AUX
admet-2626	2	11	be	be	AUX
admet-2626	2	12	surprisingly	surprisingly	ADV
admet-2626	2	13	complex	complex	ADJ
admet-2626	2	14	in	in	ADP
admet-2626	2	15	subtle	subtle	ADJ
admet-2626	2	16	ways	way	NOUN
admet-2626	2	17	.	.	PUNCT
admet-2626	3	1	this	this	DET
admet-2626	3	2	commentary	commentary	NOUN
admet-2626	3	3	examines	examine	VERB
admet-2626	3	4	the	the	DET
admet-2626	3	5	characteristics	characteristic	NOUN
admet-2626	3	6	of	of	ADP
admet-2626	3	7	such	such	ADJ
admet-2626	3	8	measurements	measurement	NOUN
admet-2626	3	9	through	through	ADP
admet-2626	3	10	case	case	NOUN
admet-2626	3	11	studies	study	NOUN
admet-2626	3	12	of	of	ADP
admet-2626	3	13	32	32	NUM
admet-2626	3	14	free	free	ADJ
admet-2626	3	15	acids	acid	NOUN
admet-2626	3	16	,	,	PUNCT
admet-2626	3	17	bases	basis	NOUN
admet-2626	3	18	,	,	PUNCT
admet-2626	3	19	and	and	CCONJ
admet-2626	3	20	ampholytes	ampholyte	NOUN
admet-2626	3	21	(	(	PUNCT
admet-2626	3	22	including	include	VERB
admet-2626	3	23	crocetin	crocetin	NOUN
admet-2626	3	24	,	,	PUNCT
admet-2626	3	25	glibenclamide	glibenclamide	NOUN
admet-2626	3	26	,	,	PUNCT
admet-2626	3	27	mellitic	mellitic	ADJ
admet-2626	3	28	acid	acid	NOUN
admet-2626	3	29	,	,	PUNCT
admet-2626	3	30	quercetin	quercetin	NOUN
admet-2626	3	31	,	,	PUNCT
admet-2626	3	32	bedaquiline	bedaquiline	NOUN
admet-2626	3	33	,	,	PUNCT
admet-2626	3	34	brigatinib	brigatinib	NOUN
admet-2626	3	35	,	,	PUNCT
admet-2626	3	36	imatinib	imatinib	NOUN
admet-2626	3	37	,	,	PUNCT
admet-2626	3	38	celecoxib	celecoxib	NOUN
admet-2626	3	39	,	,	PUNCT
admet-2626	3	40	and	and	CCONJ
admet-2626	3	41	lysine	lysine	NOUN
admet-2626	3	42	)	)	PUNCT
admet-2626	3	43	,	,	PUNCT
admet-2626	3	44	using	use	VERB
admet-2626	3	45	published	publish	VERB
admet-2626	3	46	water	water	NOUN
admet-2626	3	47	solubility	solubility	NOUN
admet-2626	3	48	data	datum	NOUN
admet-2626	3	49	.	.	PUNCT
admet-2626	4	1	computational	computational	ADJ
admet-2626	4	2	approach	approach	NOUN
admet-2626	4	3	:	:	PUNCT
admet-2626	4	4	usually	usually	ADV
admet-2626	4	5	,	,	PUNCT
admet-2626	4	6	in	in	ADP
admet-2626	4	7	such	such	ADJ
admet-2626	4	8	saturated	saturated	ADJ
admet-2626	4	9	solutions	solution	NOUN
admet-2626	4	10	,	,	PUNCT
admet-2626	4	11	the	the	DET
admet-2626	4	12	ionic	ionic	ADJ
admet-2626	4	13	strength	strength	NOUN
admet-2626	4	14	,	,	PUNCT
admet-2626	4	15	iw	iw	INTJ
admet-2626	4	16	,	,	PUNCT
admet-2626	4	17	is	be	AUX
admet-2626	4	18	close	close	ADJ
admet-2626	4	19	to	to	ADP
admet-2626	4	20	zero	zero	NUM
admet-2626	4	21	.	.	PUNCT
admet-2626	5	1	when	when	SCONJ
admet-2626	5	2	the	the	DET
admet-2626	5	3	ph	ph	NOUN
admet-2626	5	4	is	be	AUX
admet-2626	5	5	adjusted	adjust	VERB
admet-2626	5	6	away	away	ADV
admet-2626	5	7	from	from	ADP
admet-2626	5	8	phw	phw	NOUN
admet-2626	5	9	,	,	PUNCT
admet-2626	5	10	the	the	DET
admet-2626	5	11	ionic	ionic	ADJ
admet-2626	5	12	strength	strength	NOUN
admet-2626	5	13	increases	increase	NOUN
admet-2626	5	14	,	,	PUNCT
admet-2626	5	15	substantially	substantially	ADV
admet-2626	5	16	in	in	ADP
admet-2626	5	17	some	some	DET
admet-2626	5	18	cases	case	NOUN
admet-2626	5	19	(	(	PUNCT
admet-2626	5	20	e.g.	e.g.	ADV
admet-2626	5	21	iw	iw	X
admet-2626	5	22	>	>	X
admet-2626	5	23	10	10	NUM
admet-2626	5	24	m	m	NOUN
admet-2626	5	25	at	at	ADP
admet-2626	5	26	ph	ph	PROPN
admet-2626	5	27	7.4	7.4	NUM
admet-2626	5	28	for	for	ADP
admet-2626	5	29	mellitic	mellitic	ADJ
admet-2626	5	30	acid	acid	NOUN
admet-2626	5	31	and	and	CCONJ
admet-2626	5	32	lysine	lysine	NOUN
admet-2626	5	33	)	)	PUNCT
admet-2626	5	34	.	.	PUNCT
admet-2626	6	1	this	this	DET
admet-2626	6	2	change	change	NOUN
admet-2626	6	3	in	in	ADP
admet-2626	6	4	ionic	ionic	ADJ
admet-2626	6	5	strength	strength	NOUN
admet-2626	6	6	alters	alter	VERB
admet-2626	6	7	the	the	DET
admet-2626	6	8	activities	activity	NOUN
admet-2626	6	9	of	of	ADP
admet-2626	6	10	the	the	DET
admet-2626	6	11	species	specie	NOUN
admet-2626	6	12	in	in	ADP
admet-2626	6	13	solution	solution	NOUN
admet-2626	6	14	.	.	PUNCT
admet-2626	7	1	the	the	DET
admet-2626	7	2	corresponding	correspond	VERB
admet-2626	7	3	equilibrium	equilibrium	NOUN
admet-2626	7	4	constants	constant	NOUN
admet-2626	7	5	used	use	VERB
admet-2626	7	6	to	to	PART
admet-2626	7	7	calculate	calculate	VERB
admet-2626	7	8	the	the	DET
admet-2626	7	9	concentrations	concentration	NOUN
admet-2626	7	10	of	of	ADP
admet-2626	7	11	these	these	DET
admet-2626	7	12	species	specie	NOUN
admet-2626	7	13	must	must	AUX
admet-2626	7	14	be	be	AUX
admet-2626	7	15	adjusted	adjust	VERB
admet-2626	7	16	accordingly	accordingly	ADV
admet-2626	7	17	.	.	PUNCT
admet-2626	8	1	here	here	ADV
admet-2626	8	2	,	,	PUNCT
admet-2626	8	3	the	the	DET
admet-2626	8	4	stokes	stokes	PROPN
admet-2626	8	5	-	-	PUNCT
admet-2626	8	6	robinson	robinson	PROPN
admet-2626	8	7	hydration	hydration	NOUN
admet-2626	8	8	theory	theory	NOUN
admet-2626	8	9	,	,	PUNCT
admet-2626	8	10	slightly	slightly	ADV
admet-2626	8	11	modified	modify	VERB
admet-2626	8	12	with	with	ADP
admet-2626	8	13	setschenow	setschenow	NOUN
admet-2626	8	14	‘	'	PUNCT
admet-2626	8	15	salting	salt	VERB
admet-2626	8	16	-	-	PUNCT
admet-2626	8	17	out	out	ADP
admet-2626	8	18	’	'	PUNCT
admet-2626	8	19	constants	constant	NOUN
admet-2626	8	20	to	to	PART
admet-2626	8	21	account	account	VERB
admet-2626	8	22	for	for	ADP
admet-2626	8	23	solvent	solvent	ADJ
admet-2626	8	24	interactions	interaction	NOUN
admet-2626	8	25	with	with	ADP
admet-2626	8	26	unionized	unionized	ADJ
admet-2626	8	27	drugs	drug	NOUN
admet-2626	8	28	,	,	PUNCT
admet-2626	8	29	was	be	AUX
admet-2626	8	30	used	use	VERB
admet-2626	8	31	to	to	PART
admet-2626	8	32	estimate	estimate	VERB
admet-2626	8	33	activity	activity	NOUN
admet-2626	8	34	coefficients	coefficient	NOUN
admet-2626	8	35	.	.	PUNCT
admet-2626	9	1	the	the	DET
admet-2626	9	2	calculations	calculation	NOUN
admet-2626	9	3	were	be	AUX
admet-2626	9	4	performed	perform	VERB
admet-2626	9	5	with	with	ADP
admet-2626	9	6	the	the	DET
admet-2626	9	7	pdisol	pdisol	ADJ
admet-2626	9	8	-	-	PUNCT
admet-2626	9	9	x	x	NOUN
admet-2626	9	10	program	program	NOUN
admet-2626	9	11	.	.	PUNCT
admet-2626	10	1	key	key	ADJ
admet-2626	10	2	results	result	NOUN
admet-2626	10	3	:	:	PUNCT
admet-2626	10	4	given	give	VERB
admet-2626	10	5	reliably	reliably	ADV
admet-2626	10	6	-	-	PUNCT
admet-2626	10	7	measured	measure	VERB
admet-2626	10	8	values	value	NOUN
admet-2626	10	9	of	of	ADP
admet-2626	10	10	solubility	solubility	NOUN
admet-2626	10	11	in	in	ADP
admet-2626	10	12	water	water	NOUN
admet-2626	10	13	(	(	PUNCT
admet-2626	10	14	sw	sw	PROPN
admet-2626	10	15	)	)	PUNCT
admet-2626	10	16	and	and	CCONJ
admet-2626	10	17	ionization	ionization	NOUN
admet-2626	10	18	constant	constant	ADJ
admet-2626	10	19	(	(	PUNCT
admet-2626	10	20	pka	pka	NOUN
admet-2626	10	21	)	)	PUNCT
admet-2626	10	22	of	of	ADP
admet-2626	10	23	the	the	DET
admet-2626	10	24	drugs	drug	NOUN
admet-2626	10	25	and	and	CCONJ
admet-2626	10	26	assuming	assume	VERB
admet-2626	10	27	that	that	SCONJ
admet-2626	10	28	the	the	DET
admet-2626	10	29	henderson	henderson	PROPN
admet-2626	10	30	-	-	PUNCT
admet-2626	10	31	hasselbalch	hasselbalch	PROPN
admet-2626	10	32	equation	equation	NOUN
admet-2626	10	33	is	be	AUX
admet-2626	10	34	valid	valid	ADJ
admet-2626	10	35	,	,	PUNCT
admet-2626	10	36	a	a	DET
admet-2626	10	37	method	method	NOUN
admet-2626	10	38	is	be	AUX
admet-2626	10	39	described	describe	VERB
admet-2626	10	40	for	for	ADP
admet-2626	10	41	(	(	PUNCT
admet-2626	10	42	i	i	NOUN
admet-2626	10	43	)	)	PUNCT
admet-2626	10	44	adjusting	adjust	VERB
admet-2626	10	45	the	the	DET
admet-2626	10	46	measured	measured	ADJ
admet-2626	10	47	sw	sw	NOUN
admet-2626	10	48	values	value	NOUN
admet-2626	10	49	at	at	ADP
admet-2626	10	50	ionic	ionic	ADJ
admet-2626	10	51	strength	strength	NOUN
admet-2626	10	52	,	,	PUNCT
admet-2626	10	53	iw	iw	PROPN
admet-2626	10	54			NOUN
admet-2626	10	55	0	0	NUM
admet-2626	10	56	m	m	NOUN
admet-2626	10	57	,	,	PUNCT
admet-2626	10	58	to	to	ADP
admet-2626	10	59	values	value	NOUN
admet-2626	10	60	expected	expect	VERB
admet-2626	10	61	at	at	ADP
admet-2626	10	62	reference	reference	NOUN
admet-2626	10	63	ionic	ionic	ADJ
admet-2626	10	64	strength	strength	NOUN
admet-2626	10	65	,	,	PUNCT
admet-2626	10	66	iref	iref	NOUN
admet-2626	10	67	=	=	PUNCT
admet-2626	10	68	0.15	0.15	NUM
admet-2626	10	69	m	m	VERB
admet-2626	10	70	(	(	PUNCT
admet-2626	10	71	or	or	CCONJ
admet-2626	10	72	at	at	ADP
admet-2626	10	73	any	any	DET
admet-2626	10	74	other	other	ADJ
admet-2626	10	75	reasonable	reasonable	ADJ
admet-2626	10	76	reference	reference	NOUN
admet-2626	10	77	value	value	NOUN
admet-2626	10	78	)	)	PUNCT
admet-2626	10	79	,	,	PUNCT
admet-2626	10	80	(	(	PUNCT
admet-2626	10	81	ii	ii	NOUN
admet-2626	10	82	)	)	PUNCT
admet-2626	10	83	determining	determine	VERB
admet-2626	10	84	the	the	DET
admet-2626	10	85	water	water	NOUN
admet-2626	10	86	phw	phw	NOUN
admet-2626	10	87	in	in	ADP
admet-2626	10	88	saturated	saturate	VERB
admet-2626	10	89	solutions	solution	NOUN
admet-2626	10	90	of	of	ADP
admet-2626	10	91	added	add	VERB
admet-2626	10	92	neutral	neutral	ADJ
admet-2626	10	93	-	-	PUNCT
admet-2626	10	94	form	form	NOUN
admet-2626	10	95	drugs	drug	NOUN
admet-2626	10	96	;	;	PUNCT
admet-2626	10	97	(	(	PUNCT
admet-2626	10	98	iii	iii	X
admet-2626	10	99	)	)	PUNCT
admet-2626	10	100	determining	determine	VERB
admet-2626	10	101	the	the	DET
admet-2626	10	102	intrinsic	intrinsic	ADJ
admet-2626	10	103	solubility	solubility	NOUN
admet-2626	10	104	,	,	PUNCT
admet-2626	10	105	s0	s0	PROPN
admet-2626	10	106	,	,	PUNCT
admet-2626	10	107	both	both	CCONJ
admet-2626	10	108	at	at	ADP
admet-2626	10	109	iw	iw	NOUN
admet-2626	10	110	and	and	CCONJ
admet-2626	10	111	iref	iref	NOUN
admet-2626	10	112	,	,	PUNCT
admet-2626	10	113	and	and	CCONJ
admet-2626	10	114	(	(	PUNCT
admet-2626	10	115	iv	iv	X
admet-2626	10	116	)	)	PUNCT
admet-2626	10	117	using	use	VERB
admet-2626	10	118	analytic	analytic	ADJ
admet-2626	10	119	-	-	PUNCT
admet-2626	10	120	continuation	continuation	NOUN
admet-2626	10	121	in	in	ADP
admet-2626	10	122	the	the	DET
admet-2626	10	123	equilibrium	equilibrium	NOUN
admet-2626	10	124	mass	mass	PROPN
admet-2626	10	125	action	action	NOUN
admet-2626	10	126	model	model	NOUN
admet-2626	10	127	to	to	PART
admet-2626	10	128	deduce	deduce	VERB
admet-2626	10	129	the	the	DET
admet-2626	10	130	solubility	solubility	NOUN
admet-2626	10	131	values	value	NOUN
admet-2626	10	132	as	as	ADP
admet-2626	10	133	a	a	DET
admet-2626	10	134	function	function	NOUN
admet-2626	10	135	of	of	ADP
admet-2626	10	136	ph	ph	VERB
admet-2626	10	137	,	,	PUNCT
admet-2626	10	138	harmonized	harmonize	VERB
admet-2626	10	139	to	to	ADP
admet-2626	10	140	a	a	DET
admet-2626	10	141	selected	select	VERB
admet-2626	10	142	iref	iref	NOUN
admet-2626	10	143	.	.	PUNCT
admet-2626	11	1	for	for	ADP
admet-2626	11	2	highly	highly	ADV
admet-2626	11	3	soluble	soluble	ADJ
admet-2626	11	4	drugs	drug	NOUN
admet-2626	11	5	,	,	PUNCT
admet-2626	11	6	whose	whose	DET
admet-2626	11	7	iw	iw	NOUN
admet-2626	11	8	exceeds	exceed	VERB
admet-2626	11	9	0.15	0.15	NUM
admet-2626	11	10	m	m	PROPN
admet-2626	11	11	,	,	PUNCT
admet-2626	11	12	the	the	DET
admet-2626	11	13	intrinsic	intrinsic	ADJ
admet-2626	11	14	solubility	solubility	NOUN
admet-2626	11	15	values	value	NOUN
admet-2626	11	16	appear	appear	VERB
admet-2626	11	17	to	to	PART
admet-2626	11	18	depend	depend	VERB
admet-2626	11	19	on	on	ADP
admet-2626	11	20	the	the	DET
admet-2626	11	21	amount	amount	NOUN
admet-2626	11	22	of	of	ADP
admet-2626	11	23	excess	excess	ADJ
admet-2626	11	24	solid	solid	ADJ
admet-2626	11	25	added	add	VERB
admet-2626	11	26	.	.	PUNCT
admet-2626	12	1	conclusion	conclusion	NOUN
admet-2626	12	2	:	:	PUNCT
admet-2626	12	3	this	this	DET
admet-2626	12	4	commentary	commentary	NOUN
admet-2626	12	5	re	re	VERB
admet-2626	12	6	-	-	VERB
admet-2626	12	7	emphasizes	emphasize	VERB
admet-2626	12	8	that	that	SCONJ
admet-2626	12	9	measured	measure	VERB
admet-2626	12	10	sw	sw	PROPN
admet-2626	12	11	is	be	AUX
admet-2626	12	12	not	not	PART
admet-2626	12	13	generally	generally	ADV
admet-2626	12	14	the	the	DET
admet-2626	12	15	same	same	ADJ
admet-2626	12	16	as	as	ADP
admet-2626	12	17	s0	s0	PROPN
admet-2626	12	18	.	.	PUNCT
admet-2626	13	1	it	it	PRON
admet-2626	13	2	is	be	AUX
admet-2626	13	3	stressed	stress	VERB
admet-2626	13	4	that	that	SCONJ
admet-2626	13	5	transforming	transform	VERB
admet-2626	13	6	measured	measure	VERB
admet-2626	13	7	drug	drug	NOUN
admet-2626	13	8	solubility	solubility	NOUN
admet-2626	13	9	in	in	ADP
admet-2626	13	10	pure	pure	ADJ
admet-2626	13	11	water	water	NOUN
admet-2626	13	12	to	to	ADP
admet-2626	13	13	an	an	DET
admet-2626	13	14	ionic	ionic	ADJ
admet-2626	13	15	strength	strength	NOUN
admet-2626	13	16	level	level	NOUN
admet-2626	13	17	that	that	PRON
admet-2626	13	18	is	be	AUX
admet-2626	13	19	physiologically	physiologically	ADV
admet-2626	13	20	appropriate	appropriate	ADJ
admet-2626	13	21	would	would	AUX
admet-2626	13	22	better	well	ADV
admet-2626	13	23	match	match	VERB
admet-2626	13	24	the	the	DET
admet-2626	13	25	conditions	condition	NOUN
admet-2626	13	26	found	find	VERB
admet-2626	13	27	in	in	ADP
admet-2626	13	28	biological	biological	ADJ
admet-2626	13	29	media	medium	NOUN
admet-2626	13	30	,	,	PUNCT
admet-2626	13	31	potentially	potentially	ADV
admet-2626	13	32	improving	improve	VERB
admet-2626	13	33	applications	application	NOUN
admet-2626	13	34	of	of	ADP
admet-2626	13	35	solubility	solubility	NOUN
admet-2626	13	36	in	in	ADP
admet-2626	13	37	pharmaceutical	pharmaceutical	ADJ
admet-2626	13	38	research	research	NOUN
admet-2626	13	39	and	and	CCONJ
admet-2626	13	40	development	development	NOUN
admet-2626	13	41	.	.	PUNCT
admet-2626	14	1	©	©	PROPN
admet-2626	14	2	2025	2025	NUM
admet-2626	14	3	by	by	ADP
admet-2626	14	4	the	the	DET
admet-2626	14	5	authors	author	NOUN
admet-2626	14	6	.	.	PUNCT
admet-2626	15	1	this	this	DET
admet-2626	15	2	article	article	NOUN
admet-2626	15	3	is	be	AUX
admet-2626	15	4	an	an	DET
admet-2626	15	5	open	open	ADJ
admet-2626	15	6	-	-	PUNCT
admet-2626	15	7	access	access	NOUN
admet-2626	15	8	article	article	NOUN
admet-2626	15	9	distributed	distribute	VERB
admet-2626	15	10	under	under	ADP
admet-2626	15	11	the	the	DET
admet-2626	15	12	terms	term	NOUN
admet-2626	15	13	and	and	CCONJ
admet-2626	15	14	conditions	condition	NOUN
admet-2626	15	15	of	of	ADP
admet-2626	15	16	the	the	DET
admet-2626	15	17	creative	creative	ADJ
admet-2626	15	18	commons	common	NOUN
admet-2626	15	19	attribution	attribution	NOUN
admet-2626	15	20	license	license	NOUN
admet-2626	15	21	(	(	PUNCT
admet-2626	15	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2626	15	23	)	)	PUNCT
admet-2626	15	24	.	.	PUNCT
admet-2626	16	1	keywords	keyword	VERB
admet-2626	16	2	constant	constant	ADJ
admet-2626	16	3	ionic	ionic	ADJ
admet-2626	16	4	medium	medium	NOUN
admet-2626	16	5	;	;	PUNCT
admet-2626	16	6	weakly	weakly	ADJ
admet-2626	16	7	-	-	PUNCT
admet-2626	16	8	ionizable	ionizable	ADJ
admet-2626	16	9	drugs	drug	NOUN
admet-2626	16	10	,	,	PUNCT
admet-2626	16	11	calculated	calculate	VERB
admet-2626	16	12	saturation	saturation	NOUN
admet-2626	16	13	ph	ph	NOUN
admet-2626	16	14	;	;	PUNCT
admet-2626	16	15	stokes	stokes	PROPN
admet-2626	16	16	-	-	PUNCT
admet-2626	16	17	robinson	robinson	PROPN
admet-2626	16	18	hydration	hydration	NOUN
admet-2626	16	19	theory	theory	NOUN
admet-2626	16	20	;	;	PUNCT
admet-2626	16	21	salting	salt	VERB
admet-2626	16	22	-	-	PUNCT
admet-2626	16	23	out	out	NOUN
admet-2626	16	24	;	;	PUNCT
admet-2626	16	25	ambient	ambient	ADJ
admet-2626	16	26	dissolved	dissolve	VERB
admet-2626	16	27	co2	co2	NOUN
admet-2626	16	28	;	;	PUNCT
admet-2626	16	29	analytic	analytic	ADJ
admet-2626	16	30	continuation	continuation	NOUN
admet-2626	16	31	to	to	ADP
admet-2626	16	32	a	a	DET
admet-2626	16	33	full	full	ADJ
admet-2626	16	34	solubility	solubility	NOUN
admet-2626	16	35	-	-	PUNCT
admet-2626	16	36	ph	ph	NOUN
admet-2626	16	37	profile	profile	NOUN
admet-2626	16	38	introduction	introduction	NOUN
admet-2626	16	39	in	in	ADP
admet-2626	16	40	drug	drug	NOUN
admet-2626	16	41	discovery	discovery	NOUN
admet-2626	16	42	,	,	PUNCT
admet-2626	16	43	the	the	DET
admet-2626	16	44	solubility	solubility	NOUN
admet-2626	16	45	of	of	ADP
admet-2626	16	46	research	research	NOUN
admet-2626	16	47	compounds	compound	NOUN
admet-2626	16	48	in	in	ADP
admet-2626	16	49	pure	pure	ADJ
admet-2626	16	50	water	water	NOUN
admet-2626	16	51	is	be	AUX
admet-2626	16	52	a	a	DET
admet-2626	16	53	necessary	necessary	ADJ
admet-2626	16	54	initial	initial	ADJ
admet-2626	16	55	measurement	measurement	NOUN
admet-2626	16	56	for	for	ADP
admet-2626	16	57	predicting	predict	VERB
admet-2626	16	58	how	how	SCONJ
admet-2626	16	59	well	well	ADV
admet-2626	16	60	a	a	DET
admet-2626	16	61	test	test	NOUN
admet-2626	16	62	compound	compound	NOUN
admet-2626	16	63	may	may	AUX
admet-2626	16	64	dissolve	dissolve	VERB
admet-2626	16	65	in	in	ADP
admet-2626	16	66	aqueous	aqueous	ADJ
admet-2626	16	67	media	medium	NOUN
admet-2626	16	68	and	and	CCONJ
admet-2626	16	69	thus	thus	ADV
admet-2626	16	70	be	be	AUX
admet-2626	16	71	available	available	ADJ
admet-2626	16	72	for	for	ADP
admet-2626	16	73	absorption	absorption	NOUN
admet-2626	16	74	.	.	PUNCT
admet-2626	17	1	in	in	ADP
admet-2626	17	2	cases	case	NOUN
admet-2626	17	3	of	of	ADP
admet-2626	17	4	newly	newly	ADV
admet-2626	17	5	approved	approve	VERB
admet-2626	17	6	drugs	drug	NOUN
admet-2626	17	7	,	,	PUNCT
admet-2626	17	8	access	access	NOUN
admet-2626	17	9	to	to	ADP
admet-2626	17	10	the	the	DET
admet-2626	17	11	measured	measured	ADJ
admet-2626	17	12	data	datum	NOUN
admet-2626	17	13	is	be	AUX
admet-2626	17	14	limited	limit	VERB
admet-2626	17	15	.	.	PUNCT
admet-2626	18	1	finding	find	VERB
admet-2626	18	2	reliable	reliable	ADJ
admet-2626	18	3	solubility	solubility	NOUN
admet-2626	18	4	data	datum	NOUN
admet-2626	18	5	can	can	AUX
admet-2626	18	6	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	VERB
admet-2626	18	7	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	ADJ
admet-2626	18	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2626	18	9	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-2626	18	10	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2626	18	11	a.	a.	PROPN
admet-2626	18	12	avdeef	avdeef	PROPN
admet-2626	18	13	admet	admet	PROPN
admet-2626	18	14	&	&	CCONJ
admet-2626	18	15	dmpk	dmpk	PROPN
admet-2626	18	16	13(1	13(1	NUM
admet-2626	18	17	)	)	PUNCT
admet-2626	18	18	(	(	PUNCT
admet-2626	18	19	2025	2025	NUM
admet-2626	18	20	)	)	PUNCT
admet-2626	18	21	2626	2626	NUM
admet-2626	18	22	2	2	NUM
admet-2626	18	23	be	be	AUX
admet-2626	18	24	a	a	DET
admet-2626	18	25	challenge	challenge	NOUN
admet-2626	18	26	:	:	PUNCT
admet-2626	18	27	frequently	frequently	ADV
admet-2626	18	28	the	the	DET
admet-2626	18	29	only	only	ADJ
admet-2626	18	30	sources	source	NOUN
admet-2626	18	31	of	of	ADP
admet-2626	18	32	solubility	solubility	NOUN
admet-2626	18	33	information	information	NOUN
admet-2626	18	34	are	be	AUX
admet-2626	18	35	found	find	VERB
admet-2626	18	36	in	in	ADP
admet-2626	18	37	patents	patent	NOUN
admet-2626	18	38	and	and	CCONJ
admet-2626	18	39	regulatory	regulatory	ADJ
admet-2626	18	40	agency	agency	NOUN
admet-2626	18	41	public	public	ADJ
admet-2626	18	42	reports	report	NOUN
admet-2626	19	1	[	[	X
admet-2626	19	2	1	1	NUM
admet-2626	19	3	-	-	SYM
admet-2626	19	4	3	3	NUM
admet-2626	19	5	]	]	PUNCT
admet-2626	19	6	.	.	PUNCT
admet-2626	20	1	the	the	DET
admet-2626	20	2	experimental	experimental	ADJ
admet-2626	20	3	conditions	condition	NOUN
admet-2626	20	4	are	be	AUX
admet-2626	20	5	sparsely	sparsely	ADV
admet-2626	20	6	detailed	detailed	ADJ
admet-2626	20	7	in	in	ADP
admet-2626	20	8	such	such	ADJ
admet-2626	20	9	citations	citation	NOUN
admet-2626	20	10	.	.	PUNCT
admet-2626	21	1	the	the	DET
admet-2626	21	2	measurement	measurement	NOUN
admet-2626	21	3	temperature	temperature	NOUN
admet-2626	21	4	is	be	AUX
admet-2626	21	5	not	not	PART
admet-2626	21	6	always	always	ADV
admet-2626	21	7	stated	state	VERB
admet-2626	21	8	.	.	PUNCT
admet-2626	22	1	the	the	DET
admet-2626	22	2	ph	ph	NOUN
admet-2626	22	3	of	of	ADP
admet-2626	22	4	the	the	DET
admet-2626	22	5	saturated	saturate	VERB
admet-2626	22	6	solution	solution	NOUN
admet-2626	22	7	,	,	PUNCT
admet-2626	22	8	phw	phw	NOUN
admet-2626	22	9	,	,	PUNCT
admet-2626	22	10	is	be	AUX
admet-2626	22	11	hardly	hardly	ADV
admet-2626	22	12	ever	ever	ADV
admet-2626	22	13	reported	report	VERB
admet-2626	22	14	.	.	PUNCT
admet-2626	23	1	too	too	ADV
admet-2626	23	2	frequently	frequently	ADV
admet-2626	23	3	,	,	PUNCT
admet-2626	23	4	sufficient	sufficient	ADJ
admet-2626	23	5	procedural	procedural	ADJ
admet-2626	23	6	details	detail	NOUN
admet-2626	23	7	are	be	AUX
admet-2626	23	8	not	not	PART
admet-2626	23	9	revealed	reveal	VERB
admet-2626	23	10	even	even	ADV
admet-2626	23	11	in	in	ADP
admet-2626	23	12	some	some	DET
admet-2626	23	13	journal	journal	NOUN
admet-2626	23	14	publications	publication	NOUN
admet-2626	23	15	.	.	PUNCT
admet-2626	24	1	there	there	PRON
admet-2626	24	2	would	would	AUX
admet-2626	24	3	appear	appear	VERB
admet-2626	24	4	to	to	PART
admet-2626	24	5	be	be	AUX
admet-2626	24	6	many	many	ADJ
admet-2626	24	7	opportunities	opportunity	NOUN
admet-2626	24	8	for	for	ADP
admet-2626	24	9	elevating	elevate	VERB
admet-2626	24	10	the	the	DET
admet-2626	24	11	‘	'	PUNCT
admet-2626	24	12	state	state	NOUN
admet-2626	24	13	of	of	ADP
admet-2626	24	14	the	the	DET
admet-2626	24	15	art	art	NOUN
admet-2626	24	16	.	.	PUNCT
admet-2626	24	17	’	'	PUNCT
admet-2626	25	1	as	as	ADP
admet-2626	25	2	part	part	NOUN
admet-2626	25	3	of	of	ADP
admet-2626	25	4	an	an	DET
admet-2626	25	5	ongoing	ongoing	ADJ
admet-2626	25	6	interest	interest	NOUN
admet-2626	25	7	in	in	ADP
admet-2626	25	8	enhancing	enhance	VERB
admet-2626	25	9	the	the	DET
admet-2626	25	10	quality	quality	NOUN
admet-2626	25	11	of	of	ADP
admet-2626	25	12	solubility	solubility	NOUN
admet-2626	25	13	measurements	measurement	NOUN
admet-2626	25	14	of	of	ADP
admet-2626	25	15	weakly	weakly	ADJ
admet-2626	25	16	-	-	PUNCT
admet-2626	25	17	ionizable	ionizable	ADJ
admet-2626	25	18	druglike	druglike	NOUN
admet-2626	25	19	molecules	molecule	NOUN
admet-2626	25	20	[	[	X
admet-2626	25	21	4	4	NUM
admet-2626	25	22	-	-	SYM
admet-2626	25	23	7	7	NUM
admet-2626	25	24	]	]	PUNCT
admet-2626	25	25	,	,	PUNCT
admet-2626	25	26	this	this	DET
admet-2626	25	27	commentary	commentary	NOUN
admet-2626	25	28	addresses	address	VERB
admet-2626	25	29	the	the	DET
admet-2626	25	30	measurements	measurement	NOUN
admet-2626	25	31	of	of	ADP
admet-2626	25	32	unionized	unionized	ADJ
admet-2626	25	33	drug	drug	NOUN
admet-2626	25	34	solubility	solubility	NOUN
admet-2626	25	35	in	in	ADP
admet-2626	25	36	pure	pure	ADJ
admet-2626	25	37	water	water	NOUN
admet-2626	25	38	,	,	PUNCT
admet-2626	25	39	sw	sw	PROPN
admet-2626	25	40	,	,	PUNCT
admet-2626	25	41	and	and	CCONJ
admet-2626	25	42	how	how	SCONJ
admet-2626	25	43	such	such	ADJ
admet-2626	25	44	measurements	measurement	NOUN
admet-2626	25	45	can	can	AUX
admet-2626	25	46	be	be	AUX
admet-2626	25	47	realistically	realistically	ADV
admet-2626	25	48	adjusted	adjust	VERB
admet-2626	25	49	to	to	ADP
admet-2626	25	50	physiologically	physiologically	ADV
admet-2626	25	51	-	-	PUNCT
admet-2626	25	52	relevant	relevant	ADJ
admet-2626	25	53	ph	ph	ADJ
admet-2626	25	54	range	range	NOUN
admet-2626	25	55	and	and	CCONJ
admet-2626	25	56	ionic	ionic	ADJ
admet-2626	25	57	strength	strength	NOUN
admet-2626	25	58	.	.	PUNCT
admet-2626	26	1	this	this	PRON
admet-2626	26	2	is	be	AUX
admet-2626	26	3	a	a	DET
admet-2626	26	4	focused	focused	ADJ
admet-2626	26	5	discussion	discussion	NOUN
admet-2626	26	6	:	:	PUNCT
admet-2626	26	7	only	only	ADV
admet-2626	26	8	equilibrium	equilibrium	NOUN
admet-2626	26	9	solubility	solubility	NOUN
admet-2626	26	10	of	of	ADP
admet-2626	26	11	neutral	neutral	ADJ
admet-2626	26	12	-	-	PUNCT
admet-2626	26	13	form	form	NOUN
admet-2626	26	14	solids	solid	NOUN
admet-2626	26	15	is	be	AUX
admet-2626	26	16	addressed	address	VERB
admet-2626	26	17	.	.	PUNCT
admet-2626	27	1	drug	drug	NOUN
admet-2626	27	2	salts	salt	NOUN
admet-2626	27	3	are	be	AUX
admet-2626	27	4	not	not	PART
admet-2626	27	5	considered	consider	VERB
admet-2626	27	6	here	here	ADV
admet-2626	27	7	;	;	PUNCT
admet-2626	27	8	it	it	PRON
admet-2626	27	9	is	be	AUX
admet-2626	27	10	assumed	assume	VERB
admet-2626	27	11	that	that	SCONJ
admet-2626	27	12	complications	complication	NOUN
admet-2626	27	13	such	such	ADJ
admet-2626	27	14	as	as	ADP
admet-2626	27	15	aggregation	aggregation	NOUN
admet-2626	27	16	or	or	CCONJ
admet-2626	27	17	adsorption	adsorption	NOUN
admet-2626	27	18	to	to	ADP
admet-2626	27	19	solid	solid	ADJ
admet-2626	27	20	surfaces	surface	NOUN
admet-2626	27	21	do	do	AUX
admet-2626	27	22	not	not	PART
admet-2626	27	23	occur	occur	VERB
admet-2626	27	24	to	to	ADP
admet-2626	27	25	any	any	DET
admet-2626	27	26	significant	significant	ADJ
admet-2626	27	27	extent	extent	NOUN
admet-2626	27	28	(	(	PUNCT
admet-2626	27	29	i.e.	i.e.	X
admet-2626	27	30	the	the	DET
admet-2626	27	31	simple	simple	ADJ
admet-2626	27	32	henderson	henderson	PROPN
admet-2626	27	33	-	-	PUNCT
admet-2626	27	34	hasselbalch	hasselbalch	PROPN
admet-2626	27	35	equation	equation	NOUN
admet-2626	27	36	can	can	AUX
admet-2626	27	37	be	be	AUX
admet-2626	27	38	assumed	assume	VERB
admet-2626	27	39	to	to	PART
admet-2626	27	40	be	be	AUX
admet-2626	27	41	valid	valid	ADJ
admet-2626	27	42	)	)	PUNCT
admet-2626	27	43	.	.	PUNCT
admet-2626	28	1	in	in	ADP
admet-2626	28	2	ideal	ideal	ADJ
admet-2626	28	3	practice	practice	NOUN
admet-2626	28	4	[	[	X
admet-2626	28	5	4	4	NUM
admet-2626	28	6	-	-	SYM
admet-2626	28	7	7	7	NUM
admet-2626	28	8	]	]	PUNCT
admet-2626	28	9	,	,	PUNCT
admet-2626	28	10	using	use	VERB
admet-2626	28	11	the	the	DET
admet-2626	28	12	phase	phase	NOUN
admet-2626	28	13	-	-	PUNCT
admet-2626	28	14	solubility	solubility	NOUN
admet-2626	28	15	method	method	NOUN
admet-2626	28	16	[	[	X
admet-2626	28	17	8	8	NUM
admet-2626	28	18	]	]	PUNCT
admet-2626	28	19	,	,	PUNCT
admet-2626	28	20	a	a	DET
admet-2626	28	21	pure	pure	ADJ
admet-2626	28	22	weakly	weakly	ADJ
admet-2626	28	23	-	-	PUNCT
admet-2626	28	24	ionizable	ionizable	ADJ
admet-2626	28	25	drug	drug	NOUN
admet-2626	28	26	(	(	PUNCT
admet-2626	28	27	acid	acid	ADJ
admet-2626	28	28	,	,	PUNCT
admet-2626	28	29	base	base	NOUN
admet-2626	28	30	,	,	PUNCT
admet-2626	28	31	or	or	CCONJ
admet-2626	28	32	ampholyte	ampholyte	ADJ
admet-2626	28	33	)	)	PUNCT
admet-2626	28	34	in	in	ADP
admet-2626	28	35	neutral	neutral	ADJ
admet-2626	28	36	form	form	NOUN
admet-2626	28	37	is	be	AUX
admet-2626	28	38	added	add	VERB
admet-2626	28	39	to	to	ADP
admet-2626	28	40	freshly	freshly	ADV
admet-2626	28	41	-	-	PUNCT
admet-2626	28	42	distilled	distil	VERB
admet-2626	28	43	/	/	SYM
admet-2626	28	44	purified	purify	VERB
admet-2626	28	45	water	water	NOUN
admet-2626	28	46	(	(	PUNCT
admet-2626	28	47	co2	co2	NOUN
admet-2626	28	48	-	-	PUNCT
admet-2626	28	49	free	free	ADJ
admet-2626	28	50	and	and	CCONJ
admet-2626	28	51	without	without	ADP
admet-2626	28	52	buffer	buffer	NOUN
admet-2626	28	53	)	)	PUNCT
admet-2626	28	54	to	to	ADP
admet-2626	28	55	the	the	DET
admet-2626	28	56	extent	extent	NOUN
admet-2626	28	57	that	that	SCONJ
admet-2626	28	58	a	a	DET
admet-2626	28	59	stable	stable	ADJ
admet-2626	28	60	saturated	saturated	ADJ
admet-2626	28	61	suspension	suspension	NOUN
admet-2626	28	62	is	be	AUX
admet-2626	28	63	achieved	achieve	VERB
admet-2626	28	64	,	,	PUNCT
admet-2626	28	65	for	for	ADP
admet-2626	28	66	a	a	DET
admet-2626	28	67	reported	report	VERB
admet-2626	28	68	precise	precise	ADJ
admet-2626	28	69	quantity	quantity	NOUN
admet-2626	28	70	of	of	ADP
admet-2626	28	71	drug	drug	NOUN
admet-2626	28	72	added	add	VERB
admet-2626	28	73	(	(	PUNCT
admet-2626	28	74	noting	note	VERB
admet-2626	28	75	that	that	SCONJ
admet-2626	28	76	some	some	DET
admet-2626	28	77	equilibrium	equilibrium	NOUN
admet-2626	28	78	reactions	reaction	NOUN
admet-2626	28	79	can	can	AUX
admet-2626	28	80	depend	depend	VERB
admet-2626	28	81	on	on	ADP
admet-2626	28	82	the	the	DET
admet-2626	28	83	total	total	ADJ
admet-2626	28	84	amount	amount	NOUN
admet-2626	28	85	of	of	ADP
admet-2626	28	86	excess	excess	ADJ
admet-2626	28	87	solid	solid	ADJ
admet-2626	28	88	added	add	VERB
admet-2626	28	89	)	)	PUNCT
admet-2626	28	90	.	.	PUNCT
admet-2626	29	1	the	the	DET
admet-2626	29	2	suspension	suspension	NOUN
admet-2626	29	3	,	,	PUNCT
admet-2626	29	4	thermostated	thermostat	VERB
admet-2626	29	5	to	to	ADP
admet-2626	29	6	a	a	DET
admet-2626	29	7	selected	select	VERB
admet-2626	29	8	temperature	temperature	NOUN
admet-2626	29	9	(	(	PUNCT
admet-2626	29	10	usually	usually	ADV
admet-2626	29	11	25	25	NUM
admet-2626	29	12	or	or	CCONJ
admet-2626	29	13	37	37	NUM
admet-2626	29	14	°	°	NOUN
admet-2626	29	15	c	c	NOUN
admet-2626	29	16	)	)	PUNCT
admet-2626	29	17	,	,	PUNCT
admet-2626	29	18	is	be	AUX
admet-2626	29	19	allowed	allow	VERB
admet-2626	29	20	to	to	PART
admet-2626	29	21	fully	fully	ADV
admet-2626	29	22	equilibrate	equilibrate	VERB
admet-2626	29	23	,	,	PUNCT
admet-2626	29	24	which	which	PRON
admet-2626	29	25	may	may	AUX
admet-2626	29	26	take	take	VERB
admet-2626	29	27	24	24	NUM
admet-2626	29	28	h	h	NOUN
admet-2626	29	29	(	(	PUNCT
admet-2626	29	30	or	or	CCONJ
admet-2626	29	31	longer	long	ADV
admet-2626	29	32	in	in	ADP
admet-2626	29	33	the	the	DET
admet-2626	29	34	case	case	NOUN
admet-2626	29	35	of	of	ADP
admet-2626	29	36	practically	practically	ADV
admet-2626	29	37	insoluble	insoluble	ADJ
admet-2626	29	38	drugs	drug	NOUN
admet-2626	29	39	)	)	PUNCT
admet-2626	29	40	.	.	PUNCT
admet-2626	30	1	after	after	SCONJ
admet-2626	30	2	equilibration	equilibration	NOUN
admet-2626	30	3	is	be	AUX
admet-2626	30	4	reached	reach	VERB
admet-2626	30	5	,	,	PUNCT
admet-2626	30	6	the	the	DET
admet-2626	30	7	saturation	saturation	NOUN
admet-2626	30	8	ph	ph	NOUN
admet-2626	30	9	(	(	PUNCT
admet-2626	30	10	phw	phw	NOUN
admet-2626	30	11	)	)	PUNCT
admet-2626	30	12	is	be	AUX
admet-2626	30	13	precisely	precisely	ADV
admet-2626	30	14	measured	measure	VERB
admet-2626	30	15	using	use	VERB
admet-2626	30	16	a	a	DET
admet-2626	30	17	research	research	NOUN
admet-2626	30	18	-	-	PUNCT
admet-2626	30	19	grade	grade	NOUN
admet-2626	30	20	electrode	electrode	NOUN
admet-2626	30	21	calibrated	calibrate	VERB
admet-2626	30	22	and	and	CCONJ
admet-2626	30	23	standardized	standardize	VERB
admet-2626	30	24	for	for	ADP
admet-2626	30	25	research	research	NOUN
admet-2626	30	26	purposes	purpose	NOUN
admet-2626	30	27	[	[	X
admet-2626	30	28	9	9	NUM
admet-2626	30	29	]	]	PUNCT
admet-2626	30	30	.	.	PUNCT
admet-2626	31	1	before	before	SCONJ
admet-2626	31	2	the	the	DET
admet-2626	31	3	concentration	concentration	NOUN
admet-2626	31	4	of	of	ADP
admet-2626	31	5	the	the	DET
admet-2626	31	6	sparingly	sparingly	ADV
admet-2626	31	7	-	-	PUNCT
admet-2626	31	8	soluble	soluble	ADJ
admet-2626	31	9	drug	drug	NOUN
admet-2626	31	10	dissolved	dissolve	VERB
admet-2626	31	11	in	in	ADP
admet-2626	31	12	water	water	NOUN
admet-2626	31	13	is	be	AUX
admet-2626	31	14	measured	measure	VERB
admet-2626	31	15	,	,	PUNCT
admet-2626	31	16	the	the	DET
admet-2626	31	17	solidliquid	solidliquid	ADJ
admet-2626	31	18	separation	separation	NOUN
admet-2626	31	19	procedure	procedure	NOUN
admet-2626	31	20	needs	need	VERB
admet-2626	31	21	to	to	PART
admet-2626	31	22	ensure	ensure	VERB
admet-2626	31	23	that	that	SCONJ
admet-2626	31	24	the	the	DET
admet-2626	31	25	concentration	concentration	NOUN
admet-2626	31	26	of	of	ADP
admet-2626	31	27	the	the	DET
admet-2626	31	28	drug	drug	NOUN
admet-2626	31	29	in	in	ADP
admet-2626	31	30	the	the	DET
admet-2626	31	31	aqueous	aqueous	ADJ
admet-2626	31	32	phase	phase	NOUN
admet-2626	31	33	is	be	AUX
admet-2626	31	34	not	not	PART
admet-2626	31	35	significantly	significantly	ADV
admet-2626	31	36	lowered	lower	VERB
admet-2626	31	37	by	by	ADP
admet-2626	31	38	adsorption	adsorption	NOUN
admet-2626	31	39	to	to	ADP
admet-2626	31	40	surfaces	surface	NOUN
admet-2626	31	41	of	of	ADP
admet-2626	31	42	vials	vial	NOUN
admet-2626	31	43	/	/	SYM
admet-2626	31	44	filters	filter	NOUN
admet-2626	31	45	in	in	ADP
admet-2626	31	46	the	the	DET
admet-2626	31	47	separation	separation	NOUN
admet-2626	31	48	apparatus	apparatus	NOUN
admet-2626	31	49	[	[	X
admet-2626	31	50	5	5	NUM
admet-2626	31	51	]	]	PUNCT
admet-2626	31	52	.	.	PUNCT
admet-2626	32	1	when	when	SCONJ
admet-2626	32	2	a	a	DET
admet-2626	32	3	neutral	neutral	ADJ
admet-2626	32	4	weakly	weakly	ADJ
admet-2626	32	5	ionizable	ionizable	ADJ
admet-2626	32	6	drug	drug	NOUN
admet-2626	32	7	is	be	AUX
admet-2626	32	8	added	add	VERB
admet-2626	32	9	to	to	ADP
admet-2626	32	10	freshly	freshly	ADV
admet-2626	32	11	distilled	distil	VERB
admet-2626	32	12	water	water	NOUN
admet-2626	32	13	to	to	PART
admet-2626	32	14	form	form	VERB
admet-2626	32	15	a	a	DET
admet-2626	32	16	saturated	saturate	VERB
admet-2626	32	17	solution	solution	NOUN
admet-2626	32	18	,	,	PUNCT
admet-2626	32	19	the	the	DET
admet-2626	32	20	ph	ph	NOUN
admet-2626	32	21	of	of	ADP
admet-2626	32	22	the	the	DET
admet-2626	32	23	suspension	suspension	NOUN
admet-2626	32	24	can	can	AUX
admet-2626	32	25	be	be	AUX
admet-2626	32	26	substantially	substantially	ADV
admet-2626	32	27	altered	alter	VERB
admet-2626	32	28	from	from	ADP
admet-2626	32	29	the	the	DET
admet-2626	32	30	water	water	NOUN
admet-2626	32	31	ph	ph	VERB
admet-2626	32	32	7	7	ADJ
admet-2626	32	33	,	,	PUNCT
admet-2626	32	34	depending	depend	VERB
admet-2626	32	35	on	on	ADP
admet-2626	32	36	the	the	DET
admet-2626	32	37	pka	pka	PROPN
admet-2626	32	38	and	and	CCONJ
admet-2626	32	39	the	the	DET
admet-2626	32	40	intrinsic	intrinsic	ADJ
admet-2626	32	41	solubility	solubility	NOUN
admet-2626	32	42	of	of	ADP
admet-2626	32	43	the	the	DET
admet-2626	32	44	drug	drug	NOUN
admet-2626	32	45	.	.	PUNCT
admet-2626	33	1	for	for	ADP
admet-2626	33	2	sparingly	sparingly	ADV
admet-2626	33	3	soluble	soluble	ADJ
admet-2626	33	4	molecules	molecule	NOUN
admet-2626	33	5	,	,	PUNCT
admet-2626	33	6	the	the	DET
admet-2626	33	7	measured	measured	ADJ
admet-2626	33	8	solubility	solubility	NOUN
admet-2626	33	9	,	,	PUNCT
admet-2626	33	10	sw	sw	PROPN
admet-2626	33	11	,	,	PUNCT
admet-2626	33	12	can	can	AUX
admet-2626	33	13	be	be	AUX
admet-2626	33	14	expected	expect	VERB
admet-2626	33	15	to	to	PART
admet-2626	33	16	far	far	ADV
admet-2626	33	17	exceed	exceed	VERB
admet-2626	33	18	that	that	PRON
admet-2626	33	19	of	of	ADP
admet-2626	33	20	the	the	DET
admet-2626	33	21	intrinsic	intrinsic	ADJ
admet-2626	33	22	(	(	PUNCT
admet-2626	33	23	neutral	neutral	ADJ
admet-2626	33	24	form	form	NOUN
admet-2626	33	25	)	)	PUNCT
admet-2626	33	26	solubility	solubility	NOUN
admet-2626	33	27	,	,	PUNCT
admet-2626	33	28	s0	s0	PROPN
admet-2626	34	1	[	[	X
admet-2626	34	2	10	10	NUM
admet-2626	34	3	]	]	PUNCT
admet-2626	34	4	.	.	PUNCT
admet-2626	35	1	for	for	ADP
admet-2626	35	2	multiprotic	multiprotic	ADJ
admet-2626	35	3	molecules	molecule	NOUN
admet-2626	35	4	with	with	ADP
admet-2626	35	5	overlapping	overlap	VERB
admet-2626	35	6	pka	pka	PROPN
admet-2626	35	7	values	value	NOUN
admet-2626	35	8	(	(	PUNCT
admet-2626	35	9	e.g.	e.g.	ADV
admet-2626	35	10	quercetin	quercetin	NOUN
admet-2626	35	11	,	,	PUNCT
admet-2626	35	12	mellophanic	mellophanic	ADJ
admet-2626	35	13	,	,	PUNCT
admet-2626	35	14	and	and	CCONJ
admet-2626	35	15	mellitic	mellitic	ADJ
admet-2626	35	16	acids	acid	NOUN
admet-2626	35	17	)	)	PUNCT
admet-2626	35	18	,	,	PUNCT
admet-2626	35	19	the	the	DET
admet-2626	35	20	relationships	relationship	NOUN
admet-2626	35	21	between	between	ADP
admet-2626	35	22	sw	sw	PROPN
admet-2626	35	23	and	and	CCONJ
admet-2626	35	24	s0	s0	PROPN
admet-2626	35	25	can	can	AUX
admet-2626	35	26	be	be	AUX
admet-2626	35	27	complicated	complicate	VERB
admet-2626	35	28	.	.	PUNCT
admet-2626	36	1	even	even	ADV
admet-2626	36	2	in	in	ADP
admet-2626	36	3	ideal	ideal	ADJ
admet-2626	36	4	practices	practice	NOUN
admet-2626	36	5	,	,	PUNCT
admet-2626	36	6	there	there	PRON
admet-2626	36	7	are	be	VERB
admet-2626	36	8	still	still	ADV
admet-2626	36	9	neglected	neglect	VERB
admet-2626	36	10	considerations	consideration	NOUN
admet-2626	36	11	.	.	PUNCT
admet-2626	37	1	these	these	PRON
admet-2626	37	2	can	can	AUX
admet-2626	37	3	potentially	potentially	ADV
admet-2626	37	4	lead	lead	VERB
admet-2626	37	5	to	to	ADP
admet-2626	37	6	misinterpretations	misinterpretation	NOUN
admet-2626	37	7	and	and	CCONJ
admet-2626	37	8	misapplications	misapplication	NOUN
admet-2626	37	9	of	of	ADP
admet-2626	37	10	sw	sw	PROPN
admet-2626	37	11	,	,	PUNCT
admet-2626	37	12	as	as	SCONJ
admet-2626	37	13	will	will	AUX
admet-2626	37	14	be	be	AUX
admet-2626	37	15	addressed	address	VERB
admet-2626	37	16	in	in	ADP
admet-2626	37	17	this	this	DET
admet-2626	37	18	commentary	commentary	NOUN
admet-2626	37	19	.	.	PUNCT
admet-2626	38	1	for	for	ADP
admet-2626	38	2	example	example	NOUN
admet-2626	38	3	,	,	PUNCT
admet-2626	38	4	the	the	DET
admet-2626	38	5	ionic	ionic	ADJ
admet-2626	38	6	strength	strength	NOUN
admet-2626	38	7	of	of	ADP
admet-2626	38	8	the	the	DET
admet-2626	38	9	saturated	saturate	VERB
admet-2626	38	10	solutions	solution	NOUN
admet-2626	38	11	,	,	PUNCT
admet-2626	38	12	iw	iw	INTJ
admet-2626	38	13	,	,	PUNCT
admet-2626	38	14	in	in	ADP
admet-2626	38	15	the	the	DET
admet-2626	38	16	measurements	measurement	NOUN
admet-2626	38	17	is	be	AUX
admet-2626	38	18	practically	practically	ADV
admet-2626	38	19	zero	zero	NUM
admet-2626	38	20	,	,	PUNCT
admet-2626	38	21	with	with	ADP
admet-2626	38	22	some	some	DET
admet-2626	38	23	exceptions	exception	NOUN
admet-2626	38	24	.	.	PUNCT
admet-2626	39	1	in	in	ADP
admet-2626	39	2	contrast	contrast	NOUN
admet-2626	39	3	,	,	PUNCT
admet-2626	39	4	the	the	DET
admet-2626	39	5	physiologically	physiologically	ADV
admet-2626	39	6	-	-	PUNCT
admet-2626	39	7	relevant	relevant	ADJ
admet-2626	39	8	ionic	ionic	ADJ
admet-2626	39	9	strength	strength	NOUN
admet-2626	39	10	,	,	PUNCT
admet-2626	39	11	iref	iref	NOUN
admet-2626	39	12	,	,	PUNCT
admet-2626	39	13	is	be	AUX
admet-2626	39	14	often	often	ADV
admet-2626	39	15	taken	take	VERB
admet-2626	39	16	to	to	PART
admet-2626	39	17	be	be	AUX
admet-2626	39	18	0.15	0.15	NUM
admet-2626	39	19	m.	m.	NOUN
admet-2626	39	20	in	in	ADP
admet-2626	39	21	quantitative	quantitative	ADJ
admet-2626	39	22	applications	application	NOUN
admet-2626	39	23	of	of	ADP
admet-2626	39	24	sw	sw	PROPN
admet-2626	39	25	to	to	ADP
admet-2626	39	26	bio	bio	ADJ
admet-2626	39	27	-	-	ADJ
admet-2626	39	28	relevant	relevant	ADJ
admet-2626	39	29	systems	system	NOUN
admet-2626	39	30	,	,	PUNCT
admet-2626	39	31	this	this	DET
admet-2626	39	32	gap	gap	NOUN
admet-2626	39	33	between	between	ADP
admet-2626	39	34	iw	iw	NOUN
admet-2626	39	35	and	and	CCONJ
admet-2626	39	36	iref	iref	VERB
admet-2626	39	37	needs	need	VERB
admet-2626	39	38	to	to	PART
admet-2626	39	39	be	be	AUX
admet-2626	39	40	factored	factor	VERB
admet-2626	39	41	in	in	ADP
admet-2626	39	42	.	.	PUNCT
admet-2626	40	1	the	the	DET
admet-2626	40	2	relationships	relationship	NOUN
admet-2626	40	3	between	between	ADP
admet-2626	40	4	sw	sw	PROPN
admet-2626	40	5	,	,	PUNCT
admet-2626	40	6	s0	s0	PROPN
admet-2626	40	7	,	,	PUNCT
admet-2626	40	8	phw	phw	NOUN
admet-2626	40	9	,	,	PUNCT
admet-2626	40	10	and	and	CCONJ
admet-2626	40	11	pka	pka	PROPN
admet-2626	40	12	are	be	AUX
admet-2626	40	13	rigorously	rigorously	ADV
admet-2626	40	14	explored	explore	VERB
admet-2626	40	15	here	here	ADV
admet-2626	40	16	.	.	PUNCT
admet-2626	41	1	the	the	DET
admet-2626	41	2	intrinsic	intrinsic	ADJ
admet-2626	41	3	solubility	solubility	NOUN
admet-2626	41	4	,	,	PUNCT
admet-2626	41	5	s0	s0	PROPN
admet-2626	41	6	,	,	PUNCT
admet-2626	41	7	is	be	AUX
admet-2626	41	8	indicated	indicate	VERB
admet-2626	41	9	at	at	ADP
admet-2626	41	10	the	the	DET
admet-2626	41	11	ph	ph	NOUN
admet-2626	41	12	where	where	SCONJ
admet-2626	41	13	a	a	DET
admet-2626	41	14	relatively	relatively	ADV
admet-2626	41	15	soluble	soluble	ADJ
admet-2626	41	16	molecule	molecule	NOUN
admet-2626	41	17	is	be	AUX
admet-2626	41	18	practically	practically	ADV
admet-2626	41	19	at	at	ADP
admet-2626	41	20	zero	zero	NUM
admet-2626	41	21	net	net	ADJ
admet-2626	41	22	charge	charge	NOUN
admet-2626	41	23	.	.	PUNCT
admet-2626	42	1	if	if	SCONJ
admet-2626	42	2	the	the	DET
admet-2626	42	3	pka	pka	PROPN
admet-2626	42	4	and	and	CCONJ
admet-2626	42	5	sw	sw	PROPN
admet-2626	42	6	are	be	AUX
admet-2626	42	7	known	know	VERB
admet-2626	42	8	and	and	CCONJ
admet-2626	42	9	the	the	DET
admet-2626	42	10	henderson	henderson	PROPN
admet-2626	42	11	-	-	PUNCT
admet-2626	42	12	hasselbalch	hasselbalch	PROPN
admet-2626	42	13	(	(	PUNCT
admet-2626	42	14	hh	hh	NOUN
admet-2626	42	15	)	)	PUNCT
admet-2626	42	16	equation	equation	NOUN
admet-2626	42	17	is	be	AUX
admet-2626	42	18	valid	valid	ADJ
admet-2626	42	19	in	in	ADP
admet-2626	42	20	the	the	DET
admet-2626	42	21	case	case	NOUN
admet-2626	42	22	,	,	PUNCT
admet-2626	42	23	it	it	PRON
admet-2626	42	24	is	be	AUX
admet-2626	42	25	possible	possible	ADJ
admet-2626	42	26	to	to	PART
admet-2626	42	27	calculate	calculate	VERB
admet-2626	42	28	the	the	DET
admet-2626	42	29	saturation	saturation	NOUN
admet-2626	42	30	phw	phw	NOUN
admet-2626	42	31	,	,	PUNCT
admet-2626	42	32	as	as	ADV
admet-2626	42	33	well	well	ADV
admet-2626	42	34	as	as	ADP
admet-2626	42	35	s0	s0	PROPN
admet-2626	42	36	.	.	PUNCT
admet-2626	43	1	the	the	DET
admet-2626	43	2	details	detail	NOUN
admet-2626	43	3	of	of	ADP
admet-2626	43	4	such	such	ADJ
admet-2626	43	5	calculations	calculation	NOUN
admet-2626	43	6	and	and	CCONJ
admet-2626	43	7	supportive	supportive	ADJ
admet-2626	43	8	topics	topic	NOUN
admet-2626	43	9	are	be	AUX
admet-2626	43	10	presented	present	VERB
admet-2626	43	11	in	in	ADP
admet-2626	43	12	appendices	appendix	NOUN
admet-2626	43	13	a	a	DET
admet-2626	43	14	-	-	PUNCT
admet-2626	43	15	c.	c.	NOUN
admet-2626	43	16	for	for	ADP
admet-2626	43	17	the	the	DET
admet-2626	43	18	simplest	simple	ADJ
admet-2626	43	19	cases	case	NOUN
admet-2626	43	20	(	(	PUNCT
admet-2626	43	21	monoand	monoand	NOUN
admet-2626	43	22	diprotic	diprotic	ADJ
admet-2626	43	23	ionizable	ionizable	ADJ
admet-2626	43	24	molecules	molecule	NOUN
admet-2626	43	25	)	)	PUNCT
admet-2626	43	26	,	,	PUNCT
admet-2626	43	27	examples	example	NOUN
admet-2626	43	28	of	of	ADP
admet-2626	43	29	derivations	derivation	NOUN
admet-2626	43	30	of	of	ADP
admet-2626	43	31	explicit	explicit	ADJ
admet-2626	43	32	equations	equation	NOUN
admet-2626	43	33	are	be	AUX
admet-2626	43	34	presented	present	VERB
admet-2626	43	35	in	in	ADP
admet-2626	43	36	appendix	appendix	NOUN
admet-2626	43	37	c	c	NOUN
admet-2626	43	38	,	,	PUNCT
admet-2626	43	39	with	with	ADP
admet-2626	43	40	examples	example	NOUN
admet-2626	43	41	given	give	VERB
admet-2626	43	42	below	below	ADV
admet-2626	43	43	.	.	PUNCT
admet-2626	44	1	these	these	DET
admet-2626	44	2	equations	equation	NOUN
admet-2626	44	3	best	well	ADV
admet-2626	44	4	serve	serve	VERB
admet-2626	44	5	as	as	ADP
admet-2626	44	6	checks	check	NOUN
admet-2626	44	7	on	on	ADP
admet-2626	44	8	the	the	DET
admet-2626	44	9	general	general	ADJ
admet-2626	44	10	procedures	procedure	NOUN
admet-2626	44	11	developed	develop	VERB
admet-2626	44	12	here	here	ADV
admet-2626	44	13	.	.	PUNCT
admet-2626	45	1	all	all	DET
admet-2626	45	2	mass	mass	ADJ
admet-2626	45	3	action	action	NOUN
admet-2626	45	4	calculations	calculation	NOUN
admet-2626	45	5	here	here	ADV
admet-2626	45	6	were	be	AUX
admet-2626	45	7	performed	perform	VERB
admet-2626	45	8	using	use	VERB
admet-2626	45	9	general	general	ADJ
admet-2626	45	10	nonlinear	nonlinear	ADJ
admet-2626	45	11	regression	regression	NOUN
admet-2626	45	12	techniques	technique	NOUN
admet-2626	45	13	,	,	PUNCT
admet-2626	45	14	based	base	VERB
admet-2626	45	15	on	on	ADP
admet-2626	45	16	implicit	implicit	ADJ
admet-2626	45	17	equations	equation	NOUN
admet-2626	45	18	,	,	PUNCT
admet-2626	45	19	derived	derive	VERB
admet-2626	45	20	internally	internally	ADV
admet-2626	45	21	using	use	VERB
admet-2626	45	22	pdisol	pdisol	NOUN
admet-2626	45	23	-	-	PUNCT
admet-2626	45	24	x.	x.	NOUN
admet-2626	45	25	abraham	abraham	PROPN
admet-2626	45	26	and	and	CCONJ
admet-2626	45	27	le	le	X
admet-2626	46	1	[	[	X
admet-2626	46	2	10	10	NUM
admet-2626	46	3	]	]	PUNCT
admet-2626	46	4	discussed	discuss	VERB
admet-2626	46	5	the	the	DET
admet-2626	46	6	relationship	relationship	NOUN
admet-2626	46	7	between	between	ADP
admet-2626	46	8	the	the	DET
admet-2626	46	9	measured	measured	ADJ
admet-2626	46	10	sw	sw	PROPN
admet-2626	46	11	and	and	CCONJ
admet-2626	46	12	s0	s0	PROPN
admet-2626	46	13	and	and	CCONJ
admet-2626	46	14	how	how	SCONJ
admet-2626	46	15	the	the	DET
admet-2626	46	16	difference	difference	NOUN
admet-2626	46	17	between	between	ADP
admet-2626	46	18	them	they	PRON
admet-2626	46	19	depends	depend	VERB
admet-2626	46	20	on	on	ADP
admet-2626	46	21	the	the	DET
admet-2626	46	22	measured	measure	VERB
admet-2626	46	23	phw	phw	NOUN
admet-2626	46	24	.	.	PUNCT
admet-2626	47	1	for	for	ADP
admet-2626	47	2	a	a	DET
admet-2626	47	3	weak	weak	ADJ
admet-2626	47	4	acid	acid	NOUN
admet-2626	47	5	,	,	PUNCT
admet-2626	47	6	the	the	DET
admet-2626	47	7	hh	hh	ADJ
admet-2626	47	8	equation	equation	NOUN
admet-2626	47	9	(	(	PUNCT
admet-2626	47	10	eq	eq	NOUN
admet-2626	47	11	.	.	NOUN
admet-2626	47	12	a9	a9	PROPN
admet-2626	47	13	in	in	ADP
admet-2626	47	14	appendix	appendix	ADJ
admet-2626	47	15	c	c	NOUN
admet-2626	47	16	)	)	PUNCT
admet-2626	47	17	is	be	AUX
admet-2626	47	18	sw	sw	PROPN
admet-2626	47	19	=	=	PROPN
admet-2626	47	20	s0	s0	PROPN
admet-2626	47	21	(	(	PUNCT
admet-2626	47	22	1	1	NUM
admet-2626	47	23	+	+	NUM
admet-2626	47	24	10	10	NUM
admet-2626	47	25	-	-	PUNCT
admet-2626	47	26	pka+phw	pka+phw	NOUN
admet-2626	47	27	)	)	PUNCT
admet-2626	47	28	.	.	PUNCT
admet-2626	48	1	it	it	PRON
admet-2626	48	2	may	may	AUX
admet-2626	48	3	be	be	AUX
admet-2626	48	4	approximated	approximate	VERB
admet-2626	48	5	(	(	PUNCT
admet-2626	48	6	cf	cf	NOUN
admet-2626	48	7	.	.	NOUN
admet-2626	48	8	,	,	PUNCT
admet-2626	48	9	eq	eq	NOUN
admet-2626	48	10	.	.	PROPN
admet-2626	48	11	a13	a13	PROPN
admet-2626	48	12	)	)	PUNCT
admet-2626	48	13	that	that	DET
admet-2626	48	14	phw	phw	NOUN
admet-2626	48	15	≈	≈	PROPN
admet-2626	48	16	½	½	NOUN
admet-2626	48	17	(	(	PUNCT
admet-2626	48	18	ps0	ps0	VERB
admet-2626	48	19	+	+	X
admet-2626	48	20	pka	pka	NOUN
admet-2626	48	21	)	)	PUNCT
admet-2626	48	22	.	.	PUNCT
admet-2626	49	1	for	for	ADP
admet-2626	49	2	a	a	DET
admet-2626	49	3	very	very	ADV
admet-2626	49	4	soluble	soluble	ADJ
admet-2626	49	5	weak	weak	ADJ
admet-2626	49	6	admet	admet	NOUN
admet-2626	49	7	&	&	CCONJ
admet-2626	49	8	dmpk	dmpk	PROPN
admet-2626	49	9	13(1	13(1	NUM
admet-2626	49	10	)	)	PUNCT
admet-2626	49	11	(	(	PUNCT
admet-2626	49	12	2025	2025	NUM
admet-2626	49	13	)	)	PUNCT
admet-2626	49	14	2626	2626	NUM
admet-2626	49	15	transforming	transform	VERB
admet-2626	49	16	drug	drug	NOUN
admet-2626	49	17	solubility	solubility	NOUN
admet-2626	49	18	measurement	measurement	NOUN
admet-2626	49	19	doi	doi	PROPN
admet-2626	49	20	:	:	PUNCT
admet-2626	49	21	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	49	22	3	3	NUM
admet-2626	49	23	acid	acid	NOUN
admet-2626	49	24	,	,	PUNCT
admet-2626	49	25	such	such	ADJ
admet-2626	49	26	as	as	ADP
admet-2626	49	27	acetaminophen	acetaminophen	NOUN
admet-2626	49	28	,	,	PUNCT
admet-2626	49	29	a	a	DET
admet-2626	49	30	further	further	ADJ
admet-2626	49	31	simplification	simplification	NOUN
admet-2626	49	32	yields	yield	NOUN
admet-2626	49	33	phw	phw	NOUN
admet-2626	49	34	≈	≈	PROPN
admet-2626	49	35	½pka	½pka	PROPN
admet-2626	49	36	.	.	PUNCT
admet-2626	50	1	the	the	DET
admet-2626	50	2	corresponding	corresponding	ADJ
admet-2626	50	3	hh	hh	PROPN
admet-2626	50	4	equation	equation	NOUN
admet-2626	50	5	reduces	reduce	VERB
admet-2626	50	6	to	to	ADP
admet-2626	50	7	sw	sw	PROPN
admet-2626	50	8	≈	≈	PROPN
admet-2626	50	9	s0(1	s0(1	PROPN
admet-2626	50	10	+	+	CCONJ
admet-2626	50	11	ka	ka	PROPN
admet-2626	50	12	½	½	PROPN
admet-2626	50	13	)	)	PUNCT
admet-2626	50	14	,	,	PUNCT
admet-2626	50	15	where	where	SCONJ
admet-2626	50	16	to	to	ADP
admet-2626	50	17	a	a	DET
admet-2626	50	18	good	good	ADJ
admet-2626	50	19	approximation	approximation	NOUN
admet-2626	50	20	,	,	PUNCT
admet-2626	50	21	sw	sw	PROPN
admet-2626	50	22	≈	≈	PROPN
admet-2626	50	23	s0	s0	PROPN
admet-2626	50	24	(	(	PUNCT
admet-2626	50	25	cf	cf	NOUN
admet-2626	50	26	.	.	PUNCT
admet-2626	51	1	tables	table	NOUN
admet-2626	51	2	1	1	NUM
admet-2626	51	3	,	,	PUNCT
admet-2626	51	4	2	2	NUM
admet-2626	51	5	)	)	PUNCT
admet-2626	51	6	.	.	PUNCT
admet-2626	52	1	in	in	ADP
admet-2626	52	2	contrast	contrast	NOUN
admet-2626	52	3	,	,	PUNCT
admet-2626	52	4	for	for	ADP
admet-2626	52	5	a	a	DET
admet-2626	52	6	practically	practically	ADV
admet-2626	52	7	insoluble	insoluble	ADJ
admet-2626	52	8	weak	weak	ADJ
admet-2626	52	9	acid	acid	NOUN
admet-2626	52	10	(	(	PUNCT
admet-2626	52	11	e.g.	e.g.	ADV
admet-2626	52	12	crocetin	crocetin	NOUN
admet-2626	52	13	)	)	PUNCT
admet-2626	52	14	,	,	PUNCT
admet-2626	52	15	the	the	DET
admet-2626	52	16	predicted	predict	VERB
admet-2626	52	17	approximate	approximate	ADJ
admet-2626	52	18	phw	phw	NOUN
admet-2626	52	19	depends	depend	VERB
admet-2626	52	20	on	on	ADP
admet-2626	52	21	both	both	CCONJ
admet-2626	52	22	ps0	ps0	ADJ
admet-2626	52	23	and	and	CCONJ
admet-2626	52	24	pka	pka	PROPN
admet-2626	52	25	.	.	PROPN
admet-2626	52	26	substitution	substitution	NOUN
admet-2626	52	27	of	of	ADP
admet-2626	52	28	phw	phw	NOUN
admet-2626	52	29	≈	≈	PROPN
admet-2626	52	30	½	½	NOUN
admet-2626	52	31	(	(	PUNCT
admet-2626	52	32	ps0	ps0	VERB
admet-2626	52	33	+	+	X
admet-2626	52	34	pka	pka	NOUN
admet-2626	52	35	)	)	PUNCT
admet-2626	52	36	into	into	ADP
admet-2626	52	37	the	the	DET
admet-2626	52	38	hh	hh	PROPN
admet-2626	52	39	equation	equation	NOUN
admet-2626	52	40	indicates	indicate	VERB
admet-2626	52	41	that	that	SCONJ
admet-2626	52	42	sw	sw	PROPN
admet-2626	52	43	is	be	AUX
admet-2626	52	44	about	about	ADV
admet-2626	52	45	20	20	NUM
admet-2626	52	46	time	time	NOUN
admet-2626	52	47	greater	great	ADJ
admet-2626	52	48	than	than	ADP
admet-2626	52	49	s0	s0	PROPN
admet-2626	52	50	in	in	ADP
admet-2626	52	51	the	the	DET
admet-2626	52	52	case	case	NOUN
admet-2626	52	53	of	of	ADP
admet-2626	52	54	crocetin	crocetin	NOUN
admet-2626	52	55	(	(	PUNCT
admet-2626	52	56	cf	cf	NOUN
admet-2626	52	57	.	.	PUNCT
admet-2626	53	1	tables	table	NOUN
admet-2626	53	2	1	1	NUM
admet-2626	53	3	,	,	PUNCT
admet-2626	53	4	2	2	NUM
admet-2626	53	5	)	)	PUNCT
admet-2626	53	6	.	.	PUNCT
admet-2626	54	1	if	if	SCONJ
admet-2626	54	2	measured	measure	VERB
admet-2626	54	3	compounds	compound	NOUN
admet-2626	54	4	contain	contain	VERB
admet-2626	54	5	protogenic	protogenic	ADJ
admet-2626	54	6	impurities	impurity	NOUN
admet-2626	54	7	(	(	PUNCT
admet-2626	54	8	e.g.	e.g.	ADV
admet-2626	54	9	ambient	ambient	ADJ
admet-2626	54	10	co2	co2	NOUN
admet-2626	54	11	)	)	PUNCT
admet-2626	54	12	,	,	PUNCT
admet-2626	54	13	the	the	DET
admet-2626	54	14	measured	measure	VERB
admet-2626	54	15	phw	phw	NOUN
admet-2626	54	16	value	value	NOUN
admet-2626	54	17	may	may	AUX
admet-2626	54	18	be	be	AUX
admet-2626	54	19	affected	affect	VERB
admet-2626	54	20	substantially	substantially	ADV
admet-2626	54	21	when	when	SCONJ
admet-2626	54	22	the	the	DET
admet-2626	54	23	weakly	weakly	ADJ
admet-2626	54	24	ionizing	ionize	VERB
admet-2626	54	25	drug	drug	NOUN
admet-2626	54	26	has	have	VERB
admet-2626	54	27	low	low	ADJ
admet-2626	54	28	self	self	NOUN
admet-2626	54	29	-	-	PUNCT
admet-2626	54	30	buffering	buffering	NOUN
admet-2626	54	31	capacity	capacity	NOUN
admet-2626	54	32	.	.	PUNCT
admet-2626	55	1	for	for	ADP
admet-2626	55	2	example	example	NOUN
admet-2626	55	3	,	,	PUNCT
admet-2626	55	4	when	when	SCONJ
admet-2626	55	5	the	the	DET
admet-2626	55	6	aqueous	aqueous	ADJ
admet-2626	55	7	solubility	solubility	NOUN
admet-2626	55	8	of	of	ADP
admet-2626	55	9	a	a	DET
admet-2626	55	10	practically	practically	ADV
admet-2626	55	11	insoluble	insoluble	ADJ
admet-2626	55	12	free	free	ADJ
admet-2626	55	13	base	base	NOUN
admet-2626	55	14	(	(	PUNCT
admet-2626	55	15	pka	pka	X
admet-2626	55	16	>	>	X
admet-2626	55	17	9	9	NUM
admet-2626	55	18	)	)	PUNCT
admet-2626	55	19	is	be	AUX
admet-2626	55	20	measured	measure	VERB
admet-2626	55	21	in	in	ADP
admet-2626	55	22	water	water	NOUN
admet-2626	55	23	,	,	PUNCT
admet-2626	55	24	the	the	DET
admet-2626	55	25	expected	expect	VERB
admet-2626	55	26	measured	measure	VERB
admet-2626	55	27	ph	ph	NOUN
admet-2626	55	28	would	would	AUX
admet-2626	55	29	be	be	AUX
admet-2626	55	30	7	7	ADJ
admet-2626	55	31	<	<	X
admet-2626	55	32	phw	phw	NOUN
admet-2626	55	33	<	<	X
admet-2626	55	34	pka	pka	PROPN
admet-2626	55	35	and	and	CCONJ
admet-2626	55	36	barely	barely	ADV
admet-2626	55	37	affected	affect	VERB
admet-2626	55	38	by	by	ADP
admet-2626	55	39	the	the	DET
admet-2626	55	40	tiny	tiny	ADJ
admet-2626	55	41	amount	amount	NOUN
admet-2626	55	42	of	of	ADP
admet-2626	55	43	the	the	DET
admet-2626	55	44	base	base	NOUN
admet-2626	55	45	dissolved	dissolve	VERB
admet-2626	55	46	.	.	PUNCT
admet-2626	56	1	on	on	ADP
admet-2626	56	2	the	the	DET
admet-2626	56	3	other	other	ADJ
admet-2626	56	4	hand	hand	NOUN
admet-2626	56	5	,	,	PUNCT
admet-2626	56	6	the	the	DET
admet-2626	56	7	measured	measure	VERB
admet-2626	56	8	ph	ph	NOUN
admet-2626	56	9	can	can	AUX
admet-2626	56	10	be	be	AUX
admet-2626	56	11	substantially	substantially	ADV
admet-2626	56	12	affected	affect	VERB
admet-2626	56	13	by	by	ADP
admet-2626	56	14	co2	co2	NOUN
admet-2626	56	15	dissolved	dissolve	VERB
admet-2626	56	16	in	in	ADP
admet-2626	56	17	water	water	NOUN
admet-2626	56	18	.	.	PUNCT
admet-2626	57	1	this	this	DET
admet-2626	57	2	effect	effect	NOUN
admet-2626	57	3	is	be	AUX
admet-2626	57	4	frequently	frequently	ADV
admet-2626	57	5	not	not	PART
admet-2626	57	6	recognized	recognize	VERB
admet-2626	57	7	(	(	PUNCT
admet-2626	57	8	or	or	CCONJ
admet-2626	57	9	sometimes	sometimes	ADV
admet-2626	57	10	ignored	ignore	VERB
admet-2626	57	11	)	)	PUNCT
admet-2626	57	12	,	,	PUNCT
admet-2626	57	13	especially	especially	ADV
admet-2626	57	14	if	if	SCONJ
admet-2626	57	15	phw	phw	NOUN
admet-2626	57	16	is	be	AUX
admet-2626	57	17	not	not	PART
admet-2626	57	18	measured	measure	VERB
admet-2626	57	19	.	.	PUNCT
admet-2626	58	1	for	for	ADP
admet-2626	58	2	example	example	NOUN
admet-2626	58	3	,	,	PUNCT
admet-2626	58	4	log	log	VERB
admet-2626	58	5	sw	sw	PROPN
admet-2626	59	1	=	=	PRON
admet-2626	59	2	-4.87	-4.87	PRON
admet-2626	59	3	has	have	AUX
admet-2626	59	4	been	be	AUX
admet-2626	59	5	reported	report	VERB
admet-2626	59	6	for	for	ADP
admet-2626	59	7	terfenadine	terfenadine	NOUN
admet-2626	59	8	(	(	PUNCT
admet-2626	59	9	pka	pka	PROPN
admet-2626	59	10	9.77	9.77	NUM
admet-2626	59	11	)	)	PUNCT
admet-2626	59	12	dissolved	dissolve	VERB
admet-2626	59	13	in	in	ADP
admet-2626	59	14	water	water	NOUN
admet-2626	59	15	,	,	PUNCT
admet-2626	59	16	with	with	ADP
admet-2626	59	17	no	no	DET
admet-2626	59	18	further	further	ADJ
admet-2626	59	19	information	information	NOUN
admet-2626	60	1	[	[	X
admet-2626	60	2	11	11	NUM
admet-2626	60	3	]	]	PUNCT
admet-2626	60	4	.	.	PUNCT
admet-2626	61	1	in	in	ADP
admet-2626	61	2	the	the	DET
admet-2626	61	3	terfenadine	terfenadine	NOUN
admet-2626	61	4	suspension	suspension	NOUN
admet-2626	61	5	,	,	PUNCT
admet-2626	61	6	if	if	SCONJ
admet-2626	61	7	the	the	DET
admet-2626	61	8	typical	typical	ADJ
admet-2626	61	9	ambient	ambient	NOUN
admet-2626	61	10	[	[	X
admet-2626	61	11	co2	co2	NOUN
admet-2626	61	12	]	]	PUNCT
admet-2626	61	13	dissolved	dissolve	VERB
admet-2626	61	14	in	in	ADP
admet-2626	61	15	water	water	NOUN
admet-2626	61	16	were	be	AUX
admet-2626	61	17	0	0	NUM
admet-2626	61	18	,	,	PUNCT
admet-2626	61	19	10	10	NUM
admet-2626	61	20	,	,	PUNCT
admet-2626	61	21	or	or	CCONJ
admet-2626	61	22	20	20	NUM
admet-2626	61	23	μm	μm	NUM
admet-2626	61	24	,	,	PUNCT
admet-2626	61	25	the	the	DET
admet-2626	61	26	calculated	calculate	VERB
admet-2626	61	27	log	log	NOUN
admet-2626	61	28	s0	s0	NOUN
admet-2626	61	29	would	would	AUX
admet-2626	61	30	be	be	AUX
admet-2626	61	31	-5.7	-5.7	PRON
admet-2626	61	32	,	,	PUNCT
admet-2626	61	33	-6.3	-6.3	NOUN
admet-2626	61	34	,	,	PUNCT
admet-2626	61	35	or	or	CCONJ
admet-2626	61	36	-8.3	-8.3	NOUN
admet-2626	61	37	,	,	PUNCT
admet-2626	61	38	and	and	CCONJ
admet-2626	61	39	the	the	DET
admet-2626	61	40	measured	measured	ADJ
admet-2626	61	41	phw	phw	NOUN
admet-2626	61	42	would	would	AUX
admet-2626	61	43	be	be	AUX
admet-2626	61	44	9.2	9.2	NUM
admet-2626	61	45	,	,	PUNCT
admet-2626	61	46	8.5	8.5	NUM
admet-2626	61	47	,	,	PUNCT
admet-2626	61	48	or	or	CCONJ
admet-2626	61	49	6.6	6.6	NUM
admet-2626	61	50	,	,	PUNCT
admet-2626	61	51	respectively	respectively	ADV
admet-2626	61	52	in	in	ADP
admet-2626	61	53	the	the	DET
admet-2626	61	54	three	three	NUM
admet-2626	61	55	cases	case	NOUN
admet-2626	61	56	.	.	PUNCT
admet-2626	62	1	generally	generally	ADV
admet-2626	62	2	,	,	PUNCT
admet-2626	62	3	the	the	DET
admet-2626	62	4	error	error	NOUN
admet-2626	62	5	in	in	ADP
admet-2626	62	6	the	the	DET
admet-2626	62	7	calculated	calculated	ADJ
admet-2626	62	8	s0	s0	NOUN
admet-2626	62	9	of	of	ADP
admet-2626	62	10	practically	practically	ADV
admet-2626	62	11	insoluble	insoluble	ADJ
admet-2626	62	12	basic	basic	ADJ
admet-2626	62	13	drugs	drug	NOUN
admet-2626	62	14	in	in	ADP
admet-2626	62	15	water	water	NOUN
admet-2626	62	16	is	be	AUX
admet-2626	62	17	expected	expect	VERB
admet-2626	62	18	to	to	PART
admet-2626	62	19	be	be	AUX
admet-2626	62	20	substantial	substantial	ADJ
admet-2626	62	21	(	(	PUNCT
admet-2626	62	22	up	up	ADP
admet-2626	62	23	to	to	PART
admet-2626	62	24	2	2	NUM
admet-2626	62	25	-	-	SYM
admet-2626	62	26	3	3	NUM
admet-2626	62	27	log	log	NOUN
admet-2626	62	28	units	unit	NOUN
admet-2626	62	29	)	)	PUNCT
admet-2626	62	30	,	,	PUNCT
admet-2626	62	31	since	since	SCONJ
admet-2626	62	32	it	it	PRON
admet-2626	62	33	is	be	AUX
admet-2626	62	34	very	very	ADV
admet-2626	62	35	difficult	difficult	ADJ
admet-2626	62	36	to	to	PART
admet-2626	62	37	eliminate	eliminate	VERB
admet-2626	62	38	co2	co2	NOUN
admet-2626	62	39	entirely	entirely	ADV
admet-2626	62	40	simply	simply	ADV
admet-2626	62	41	by	by	ADP
admet-2626	62	42	spurging	spurge	VERB
admet-2626	62	43	the	the	DET
admet-2626	62	44	solution	solution	NOUN
admet-2626	62	45	with	with	ADP
admet-2626	62	46	an	an	DET
admet-2626	62	47	inert	inert	ADJ
admet-2626	62	48	gas	gas	NOUN
admet-2626	62	49	.	.	PUNCT
admet-2626	63	1	hence	hence	ADV
admet-2626	63	2	,	,	PUNCT
admet-2626	63	3	with	with	ADP
admet-2626	63	4	poorly	poorly	ADV
admet-2626	63	5	-	-	PUNCT
admet-2626	63	6	soluble	soluble	ADJ
admet-2626	63	7	basic	basic	ADJ
admet-2626	63	8	drugs	drug	NOUN
admet-2626	63	9	,	,	PUNCT
admet-2626	63	10	it	it	PRON
admet-2626	63	11	is	be	AUX
admet-2626	63	12	critically	critically	ADV
admet-2626	63	13	important	important	ADJ
admet-2626	63	14	to	to	PART
admet-2626	63	15	measure	measure	VERB
admet-2626	63	16	the	the	DET
admet-2626	63	17	equilibrium	equilibrium	NOUN
admet-2626	63	18	saturation	saturation	NOUN
admet-2626	63	19	phw	phw	NOUN
admet-2626	63	20	.	.	PUNCT
admet-2626	64	1	it	it	PRON
admet-2626	64	2	is	be	AUX
admet-2626	64	3	expected	expect	VERB
admet-2626	64	4	that	that	SCONJ
admet-2626	64	5	experienced	experienced	ADJ
admet-2626	64	6	solution	solution	NOUN
admet-2626	64	7	chemists	chemist	NOUN
admet-2626	64	8	recognize	recognize	VERB
admet-2626	64	9	this	this	DET
admet-2626	64	10	possible	possible	ADJ
admet-2626	64	11	source	source	NOUN
admet-2626	64	12	of	of	ADP
admet-2626	64	13	error	error	NOUN
admet-2626	64	14	and	and	CCONJ
admet-2626	64	15	thus	thus	ADV
admet-2626	64	16	routinely	routinely	ADV
admet-2626	64	17	measure	measure	VERB
admet-2626	64	18	and	and	CCONJ
admet-2626	64	19	report	report	VERB
admet-2626	64	20	the	the	DET
admet-2626	64	21	equilibrium	equilibrium	NOUN
admet-2626	64	22	phw	phw	NOUN
admet-2626	64	23	when	when	SCONJ
admet-2626	64	24	sw	sw	PROPN
admet-2626	64	25	is	be	AUX
admet-2626	64	26	determined	determine	VERB
admet-2626	64	27	.	.	PUNCT
admet-2626	65	1	for	for	ADP
admet-2626	65	2	reliably	reliably	ADV
admet-2626	65	3	-	-	PUNCT
admet-2626	65	4	measured	measure	VERB
admet-2626	65	5	phw	phw	NOUN
admet-2626	65	6	,	,	PUNCT
admet-2626	65	7	it	it	PRON
admet-2626	65	8	is	be	AUX
admet-2626	65	9	possible	possible	ADJ
admet-2626	65	10	to	to	PART
admet-2626	65	11	estimate	estimate	VERB
admet-2626	65	12	the	the	DET
admet-2626	65	13	ambient	ambient	ADJ
admet-2626	65	14	concentration	concentration	NOUN
admet-2626	65	15	of	of	ADP
admet-2626	65	16	co2	co2	NOUN
admet-2626	65	17	and	and	CCONJ
admet-2626	65	18	correct	correct	ADJ
admet-2626	65	19	for	for	ADP
admet-2626	65	20	its	its	PRON
admet-2626	65	21	effect	effect	NOUN
admet-2626	65	22	.	.	PUNCT
admet-2626	66	1	but	but	CCONJ
admet-2626	66	2	,	,	PUNCT
admet-2626	66	3	measuring	measure	VERB
admet-2626	66	4	the	the	DET
admet-2626	66	5	ph	ph	NOUN
admet-2626	66	6	accurately	accurately	ADV
admet-2626	66	7	in	in	ADP
admet-2626	66	8	an	an	DET
admet-2626	66	9	unbuffered	unbuffered	ADJ
admet-2626	66	10	solution	solution	NOUN
admet-2626	66	11	is	be	AUX
admet-2626	66	12	yet	yet	ADV
admet-2626	66	13	another	another	DET
admet-2626	66	14	challenge	challenge	NOUN
admet-2626	66	15	,	,	PUNCT
admet-2626	66	16	because	because	SCONJ
admet-2626	66	17	a	a	DET
admet-2626	66	18	ph	ph	ADJ
admet-2626	66	19	electrode	electrode	NOUN
admet-2626	66	20	,	,	PUNCT
admet-2626	66	21	being	be	AUX
admet-2626	66	22	an	an	DET
admet-2626	66	23	electrochemical	electrochemical	ADJ
admet-2626	66	24	device	device	NOUN
admet-2626	66	25	,	,	PUNCT
admet-2626	66	26	requires	require	VERB
admet-2626	66	27	a	a	DET
admet-2626	66	28	certain	certain	ADJ
admet-2626	66	29	amount	amount	NOUN
admet-2626	66	30	of	of	ADP
admet-2626	66	31	electrical	electrical	ADJ
admet-2626	66	32	current	current	NOUN
admet-2626	66	33	for	for	ADP
admet-2626	66	34	its	its	PRON
admet-2626	66	35	operation	operation	NOUN
admet-2626	66	36	,	,	PUNCT
admet-2626	66	37	to	to	PART
admet-2626	66	38	stabilized	stabilize	VERB
admet-2626	66	39	potentially	potentially	ADV
admet-2626	66	40	erratic	erratic	ADJ
admet-2626	66	41	reference	reference	NOUN
admet-2626	66	42	electrode	electrode	NOUN
admet-2626	66	43	junction	junction	NOUN
admet-2626	66	44	voltages	voltage	NOUN
admet-2626	66	45	.	.	PUNCT
admet-2626	67	1	electrodes	electrode	NOUN
admet-2626	67	2	in	in	ADP
admet-2626	67	3	such	such	ADJ
admet-2626	67	4	applications	application	NOUN
admet-2626	67	5	need	need	VERB
admet-2626	67	6	to	to	PART
admet-2626	67	7	be	be	AUX
admet-2626	67	8	calibrated	calibrate	VERB
admet-2626	67	9	/	/	SYM
admet-2626	67	10	standardized	standardize	VERB
admet-2626	67	11	in	in	ADP
admet-2626	67	12	special	special	ADJ
admet-2626	67	13	ways	way	NOUN
admet-2626	67	14	[	[	X
admet-2626	67	15	12	12	NUM
admet-2626	67	16	]	]	PUNCT
admet-2626	67	17	(	(	PUNCT
admet-2626	67	18	pp	pp	ADJ
admet-2626	67	19	.	.	PUNCT
admet-2626	68	1	55	55	NUM
admet-2626	68	2	-	-	SYM
admet-2626	68	3	66	66	NUM
admet-2626	68	4	,	,	PUNCT
admet-2626	68	5	130	130	NUM
admet-2626	68	6	-	-	SYM
admet-2626	68	7	145	145	NUM
admet-2626	68	8	)	)	PUNCT
admet-2626	68	9	.	.	PUNCT
admet-2626	69	1	solution	solution	NOUN
admet-2626	69	2	chemists	chemist	NOUN
admet-2626	69	3	can	can	AUX
admet-2626	69	4	overcome	overcome	VERB
admet-2626	69	5	this	this	DET
admet-2626	69	6	low	low	ADJ
admet-2626	69	7	conductivity	conductivity	NOUN
admet-2626	69	8	challenge	challenge	NOUN
admet-2626	69	9	by	by	ADP
admet-2626	69	10	adding	add	VERB
admet-2626	69	11	a	a	DET
admet-2626	69	12	small	small	ADJ
admet-2626	69	13	amount	amount	NOUN
admet-2626	69	14	of	of	ADP
admet-2626	69	15	inert	inert	ADJ
admet-2626	69	16	electrolyte	electrolyte	NOUN
admet-2626	69	17	to	to	ADP
admet-2626	69	18	the	the	DET
admet-2626	69	19	suspension	suspension	NOUN
admet-2626	69	20	(	(	PUNCT
admet-2626	69	21	e.g.	e.g.	ADV
admet-2626	69	22	1	1	NUM
admet-2626	69	23	-	-	SYM
admet-2626	69	24	5	5	NUM
admet-2626	69	25	mm	mm	NOUN
admet-2626	69	26	nacl	nacl	NOUN
admet-2626	69	27	)	)	PUNCT
admet-2626	69	28	,	,	PUNCT
admet-2626	69	29	which	which	PRON
admet-2626	69	30	sufficiently	sufficiently	ADV
admet-2626	69	31	lessens	lessen	VERB
admet-2626	69	32	the	the	DET
admet-2626	69	33	electrode	electrode	NOUN
admet-2626	69	34	junction	junction	NOUN
admet-2626	69	35	errors	error	NOUN
admet-2626	69	36	.	.	PUNCT
admet-2626	70	1	in	in	ADP
admet-2626	70	2	this	this	DET
admet-2626	70	3	commentary	commentary	NOUN
admet-2626	70	4	,	,	PUNCT
admet-2626	70	5	case	case	NOUN
admet-2626	70	6	studies	study	NOUN
admet-2626	70	7	of	of	ADP
admet-2626	70	8	sixteen	sixteen	NUM
admet-2626	70	9	weak	weak	ADJ
admet-2626	70	10	acids	acid	NOUN
admet-2626	70	11	,	,	PUNCT
admet-2626	70	12	ten	ten	NUM
admet-2626	70	13	weak	weak	ADJ
admet-2626	70	14	bases	basis	NOUN
admet-2626	70	15	,	,	PUNCT
admet-2626	70	16	and	and	CCONJ
admet-2626	70	17	six	six	NUM
admet-2626	70	18	ampholytes	ampholyte	NOUN
admet-2626	70	19	are	be	AUX
admet-2626	70	20	used	use	VERB
admet-2626	70	21	to	to	PART
admet-2626	70	22	explore	explore	VERB
admet-2626	70	23	the	the	DET
admet-2626	70	24	solution	solution	NOUN
admet-2626	70	25	mechanistic	mechanistic	ADJ
admet-2626	70	26	aspects	aspect	NOUN
admet-2626	70	27	of	of	ADP
admet-2626	70	28	the	the	DET
admet-2626	70	29	subtle	subtle	ADJ
admet-2626	70	30	complexity	complexity	NOUN
admet-2626	70	31	derived	derive	VERB
admet-2626	70	32	from	from	ADP
admet-2626	70	33	reported	report	VERB
admet-2626	70	34	weakly	weakly	ADJ
admet-2626	70	35	-	-	PUNCT
admet-2626	70	36	ionizable	ionizable	ADJ
admet-2626	70	37	drug	drug	NOUN
admet-2626	70	38	solubility	solubility	NOUN
admet-2626	70	39	measurements	measurement	NOUN
admet-2626	70	40	in	in	ADP
admet-2626	70	41	pure	pure	ADJ
admet-2626	70	42	water	water	NOUN
admet-2626	70	43	.	.	PUNCT
admet-2626	71	1	although	although	SCONJ
admet-2626	71	2	less	less	ADV
admet-2626	71	3	evident	evident	ADJ
admet-2626	71	4	in	in	ADP
admet-2626	71	5	low	low	ADJ
admet-2626	71	6	-	-	PUNCT
admet-2626	71	7	soluble	soluble	ADJ
admet-2626	71	8	drugs	drug	NOUN
admet-2626	71	9	,	,	PUNCT
admet-2626	71	10	the	the	DET
admet-2626	71	11	ionic	ionic	ADJ
admet-2626	71	12	strength	strength	NOUN
admet-2626	71	13	of	of	ADP
admet-2626	71	14	a	a	DET
admet-2626	71	15	saturated	saturate	VERB
admet-2626	71	16	solution	solution	NOUN
admet-2626	71	17	of	of	ADP
admet-2626	71	18	a	a	DET
admet-2626	71	19	strongly	strongly	ADV
admet-2626	71	20	self	self	NOUN
admet-2626	71	21	-	-	PUNCT
admet-2626	71	22	buffered	buffer	VERB
admet-2626	71	23	soluble	soluble	ADJ
admet-2626	71	24	molecule	molecule	NOUN
admet-2626	71	25	can	can	AUX
admet-2626	71	26	reach	reach	VERB
admet-2626	71	27	high	high	ADJ
admet-2626	71	28	values	value	NOUN
admet-2626	71	29	when	when	SCONJ
admet-2626	71	30	ph	ph	NOUN
admet-2626	71	31	is	be	AUX
admet-2626	71	32	adjusted	adjust	VERB
admet-2626	71	33	away	away	ADV
admet-2626	71	34	from	from	ADP
admet-2626	71	35	phw	phw	NOUN
admet-2626	71	36	(	(	PUNCT
admet-2626	71	37	e.g.	e.g.	ADV
admet-2626	71	38	i	i	X
admet-2626	71	39	>	>	X
admet-2626	71	40	10	10	NUM
admet-2626	71	41	m	m	NOUN
admet-2626	71	42	at	at	ADP
admet-2626	71	43	ph	ph	PROPN
admet-2626	71	44	7.4	7.4	NUM
admet-2626	71	45	for	for	ADP
admet-2626	71	46	lysine	lysine	NOUN
admet-2626	71	47	and	and	CCONJ
admet-2626	71	48	mellitic	mellitic	ADJ
admet-2626	71	49	acid	acid	NOUN
admet-2626	71	50	)	)	PUNCT
admet-2626	71	51	.	.	PUNCT
admet-2626	72	1	this	this	DET
admet-2626	72	2	increase	increase	NOUN
admet-2626	72	3	in	in	ADP
admet-2626	72	4	i	i	PRON
admet-2626	72	5	is	be	AUX
admet-2626	72	6	due	due	ADJ
admet-2626	72	7	to	to	ADP
admet-2626	72	8	increased	increase	VERB
admet-2626	72	9	ionization	ionization	NOUN
admet-2626	72	10	of	of	ADP
admet-2626	72	11	the	the	DET
admet-2626	72	12	initially	initially	ADV
admet-2626	72	13	minimally	minimally	ADV
admet-2626	72	14	-	-	PUNCT
admet-2626	72	15	charged	charge	VERB
admet-2626	72	16	drug	drug	NOUN
admet-2626	72	17	.	.	PUNCT
admet-2626	73	1	the	the	DET
admet-2626	73	2	activities	activity	NOUN
admet-2626	73	3	of	of	ADP
admet-2626	73	4	all	all	DET
admet-2626	73	5	species	specie	NOUN
admet-2626	73	6	involved	involve	VERB
admet-2626	73	7	change	change	NOUN
admet-2626	73	8	substantially	substantially	ADV
admet-2626	73	9	,	,	PUNCT
admet-2626	73	10	for	for	ADP
admet-2626	73	11	which	which	PRON
admet-2626	73	12	corrections	correction	NOUN
admet-2626	73	13	can	can	AUX
admet-2626	73	14	(	(	PUNCT
admet-2626	73	15	and	and	CCONJ
admet-2626	73	16	should	should	AUX
admet-2626	73	17	)	)	PUNCT
admet-2626	73	18	be	be	AUX
admet-2626	73	19	made	make	VERB
admet-2626	73	20	.	.	PUNCT
admet-2626	74	1	the	the	DET
admet-2626	74	2	stokes	stokes	PROPN
admet-2626	74	3	-	-	PUNCT
admet-2626	74	4	robinson	robinson	PROPN
admet-2626	74	5	hydration	hydration	NOUN
admet-2626	74	6	theory	theory	NOUN
admet-2626	74	7	[	[	X
admet-2626	74	8	13,14	13,14	NUM
admet-2626	74	9	]	]	PUNCT
admet-2626	74	10	,	,	PUNCT
admet-2626	74	11	slightly	slightly	ADV
admet-2626	74	12	modified	modify	VERB
admet-2626	74	13	with	with	ADP
admet-2626	74	14	setschenow	setschenow	NOUN
admet-2626	74	15	‘	'	PUNCT
admet-2626	74	16	salting	salt	VERB
admet-2626	74	17	-	-	PUNCT
admet-2626	74	18	out	out	ADP
admet-2626	74	19	’	'	PUNCT
admet-2626	74	20	constants	constant	NOUN
admet-2626	74	21	[	[	X
admet-2626	74	22	15	15	NUM
admet-2626	74	23	,	,	PUNCT
admet-2626	74	24	and	and	CCONJ
admet-2626	74	25	references	reference	NOUN
admet-2626	74	26	therein	therein	ADV
admet-2626	74	27	]	]	PUNCT
admet-2626	74	28	to	to	PART
admet-2626	74	29	account	account	VERB
admet-2626	74	30	for	for	ADP
admet-2626	74	31	uncharged	uncharged	ADJ
admet-2626	74	32	drug	drug	NOUN
admet-2626	74	33	interactions	interaction	NOUN
admet-2626	74	34	with	with	ADP
admet-2626	74	35	the	the	DET
admet-2626	74	36	solvent	solvent	NOUN
admet-2626	74	37	,	,	PUNCT
admet-2626	74	38	was	be	AUX
admet-2626	74	39	used	use	VERB
admet-2626	74	40	to	to	PART
admet-2626	74	41	estimate	estimate	VERB
admet-2626	74	42	activity	activity	NOUN
admet-2626	74	43	coefficients	coefficient	NOUN
admet-2626	74	44	.	.	PUNCT
admet-2626	75	1	given	give	VERB
admet-2626	75	2	reliably	reliably	ADV
admet-2626	75	3	-	-	PUNCT
admet-2626	75	4	measured	measure	VERB
admet-2626	75	5	values	value	NOUN
admet-2626	75	6	of	of	ADP
admet-2626	75	7	sw	sw	PROPN
admet-2626	75	8	and	and	CCONJ
admet-2626	75	9	pka	pka	PROPN
admet-2626	75	10	of	of	ADP
admet-2626	75	11	a	a	DET
admet-2626	75	12	druglike	druglike	NOUN
admet-2626	75	13	molecule	molecule	NOUN
admet-2626	75	14	,	,	PUNCT
admet-2626	75	15	a	a	DET
admet-2626	75	16	rigorous	rigorous	ADJ
admet-2626	75	17	method	method	NOUN
admet-2626	75	18	is	be	AUX
admet-2626	75	19	described	describe	VERB
admet-2626	75	20	here	here	ADV
admet-2626	75	21	for	for	ADP
admet-2626	75	22	(	(	PUNCT
admet-2626	75	23	i	i	NOUN
admet-2626	75	24	)	)	PUNCT
admet-2626	75	25	adjusting	adjust	VERB
admet-2626	75	26	sw	sw	NOUN
admet-2626	75	27	from	from	ADP
admet-2626	75	28	zero	zero	NUM
admet-2626	75	29	ionic	ionic	ADJ
admet-2626	75	30	strength	strength	NOUN
admet-2626	75	31	to	to	ADP
admet-2626	75	32	0.15	0.15	NUM
admet-2626	75	33	m	m	VERB
admet-2626	75	34	(	(	PUNCT
admet-2626	75	35	or	or	CCONJ
admet-2626	75	36	a	a	DET
admet-2626	75	37	similar	similar	ADJ
admet-2626	75	38	practical	practical	ADJ
admet-2626	75	39	value	value	NOUN
admet-2626	75	40	)	)	PUNCT
admet-2626	75	41	,	,	PUNCT
admet-2626	75	42	(	(	PUNCT
admet-2626	75	43	ii	ii	NOUN
admet-2626	75	44	)	)	PUNCT
admet-2626	75	45	calculating	calculate	VERB
admet-2626	75	46	the	the	DET
admet-2626	75	47	saturation	saturation	NOUN
admet-2626	75	48	phw	phw	NOUN
admet-2626	75	49	,	,	PUNCT
admet-2626	75	50	(	(	PUNCT
admet-2626	75	51	iii	iii	NOUN
admet-2626	75	52	)	)	PUNCT
admet-2626	75	53	calculating	calculate	VERB
admet-2626	75	54	the	the	DET
admet-2626	75	55	intrinsic	intrinsic	ADJ
admet-2626	75	56	solubility	solubility	NOUN
admet-2626	75	57	,	,	PUNCT
admet-2626	75	58	s0	s0	PROPN
admet-2626	75	59	,	,	PUNCT
admet-2626	75	60	and	and	CCONJ
admet-2626	75	61	(	(	PUNCT
admet-2626	75	62	iv	iv	X
admet-2626	75	63	)	)	PUNCT
admet-2626	75	64	using	use	VERB
admet-2626	75	65	analytic	analytic	ADJ
admet-2626	75	66	-	-	PUNCT
admet-2626	75	67	continuation	continuation	NOUN
admet-2626	75	68	in	in	ADP
admet-2626	75	69	the	the	DET
admet-2626	75	70	equilibrium	equilibrium	NOUN
admet-2626	75	71	mass	mass	PROPN
admet-2626	75	72	action	action	NOUN
admet-2626	75	73	model	model	NOUN
admet-2626	75	74	to	to	PART
admet-2626	75	75	deduce	deduce	VERB
admet-2626	75	76	the	the	DET
admet-2626	75	77	solubility	solubility	NOUN
admet-2626	75	78	values	value	NOUN
admet-2626	75	79	as	as	ADP
admet-2626	75	80	a	a	DET
admet-2626	75	81	function	function	NOUN
admet-2626	75	82	of	of	ADP
admet-2626	75	83	ph	ph	NOUN
admet-2626	75	84	at	at	ADP
admet-2626	75	85	a	a	DET
admet-2626	75	86	selected	select	VERB
admet-2626	75	87	reference	reference	NOUN
admet-2626	75	88	ionic	ionic	ADJ
admet-2626	75	89	strength	strength	NOUN
admet-2626	75	90	.	.	PUNCT
admet-2626	76	1	computational	computational	ADJ
admet-2626	76	2	methods	method	NOUN
admet-2626	76	3	literature	literature	PROPN
admet-2626	76	4	data	datum	NOUN
admet-2626	76	5	used	use	VERB
admet-2626	76	6	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	76	7	a.	a.	NOUN
admet-2626	76	8	avdeef	avdeef	PROPN
admet-2626	76	9	admet	admet	PROPN
admet-2626	76	10	&	&	CCONJ
admet-2626	76	11	dmpk	dmpk	PROPN
admet-2626	76	12	13(1	13(1	NUM
admet-2626	76	13	)	)	PUNCT
admet-2626	76	14	(	(	PUNCT
admet-2626	76	15	2025	2025	NUM
admet-2626	76	16	)	)	PUNCT
admet-2626	76	17	2626	2626	NUM
admet-2626	76	18	4	4	NUM
admet-2626	76	19	to	to	PART
admet-2626	76	20	probe	probe	VERB
admet-2626	76	21	the	the	DET
admet-2626	76	22	characteristics	characteristic	NOUN
admet-2626	76	23	of	of	ADP
admet-2626	76	24	solubility	solubility	NOUN
admet-2626	76	25	of	of	ADP
admet-2626	76	26	neutral	neutral	ADJ
admet-2626	76	27	-	-	PUNCT
admet-2626	76	28	form	form	NOUN
admet-2626	76	29	drugs	drug	NOUN
admet-2626	76	30	added	add	VERB
admet-2626	76	31	in	in	ADP
admet-2626	76	32	excess	excess	NOUN
admet-2626	76	33	to	to	ADP
admet-2626	76	34	pure	pure	ADJ
admet-2626	76	35	water	water	NOUN
admet-2626	76	36	,	,	PUNCT
admet-2626	76	37	the	the	DET
admet-2626	76	38	measured	measure	VERB
admet-2626	76	39	sw	sw	PROPN
admet-2626	76	40	values	value	NOUN
admet-2626	76	41	of	of	ADP
admet-2626	76	42	thirty	thirty	NUM
admet-2626	76	43	-	-	PUNCT
admet-2626	76	44	two	two	NUM
admet-2626	76	45	weakly	weakly	ADJ
admet-2626	76	46	-	-	PUNCT
admet-2626	76	47	ionizable	ionizable	ADJ
admet-2626	76	48	druglike	druglike	NOUN
admet-2626	76	49	molecules	molecule	NOUN
admet-2626	76	50	were	be	AUX
admet-2626	76	51	taken	take	VERB
admet-2626	76	52	from	from	ADP
admet-2626	76	53	published	publish	VERB
admet-2626	76	54	sources	source	NOUN
admet-2626	77	1	[	[	X
admet-2626	77	2	16	16	NUM
admet-2626	77	3	-	-	SYM
admet-2626	77	4	27	27	NUM
admet-2626	77	5	]	]	PUNCT
admet-2626	77	6	.	.	PUNCT
admet-2626	78	1	a	a	DET
admet-2626	78	2	systematic	systematic	ADJ
admet-2626	78	3	series	series	NOUN
admet-2626	78	4	of	of	ADP
admet-2626	78	5	benzene	benzene	ADJ
admet-2626	78	6	carboxylic	carboxylic	ADJ
admet-2626	78	7	acids	acid	NOUN
admet-2626	78	8	(	(	PUNCT
admet-2626	78	9	benzoic	benzoic	ADJ
admet-2626	78	10	,	,	PUNCT
admet-2626	78	11	phthalic	phthalic	ADJ
admet-2626	78	12	,	,	PUNCT
admet-2626	78	13	trimellitic	trimellitic	ADJ
admet-2626	78	14	,	,	PUNCT
admet-2626	78	15	hemimellitic	hemimellitic	ADJ
admet-2626	78	16	,	,	PUNCT
admet-2626	78	17	pyromellitic	pyromellitic	ADJ
admet-2626	78	18	,	,	PUNCT
admet-2626	78	19	mellophanic	mellophanic	ADJ
admet-2626	78	20	,	,	PUNCT
admet-2626	78	21	benzene	benzene	NOUN
admet-2626	78	22	pentacarboxylic	pentacarboxylic	NOUN
admet-2626	78	23	,	,	PUNCT
admet-2626	78	24	and	and	CCONJ
admet-2626	78	25	mellitic	mellitic	ADJ
admet-2626	78	26	acid	acid	NOUN
admet-2626	78	27	)	)	PUNCT
admet-2626	78	28	and	and	CCONJ
admet-2626	78	29	eight	eight	NUM
admet-2626	78	30	other	other	ADJ
admet-2626	78	31	weak	weak	ADJ
admet-2626	78	32	acids	acid	NOUN
admet-2626	78	33	covering	cover	VERB
admet-2626	78	34	a	a	DET
admet-2626	78	35	wide	wide	ADJ
admet-2626	78	36	range	range	NOUN
admet-2626	78	37	of	of	ADP
admet-2626	78	38	solubility	solubility	NOUN
admet-2626	78	39	values	value	NOUN
admet-2626	78	40	(	(	PUNCT
admet-2626	78	41	acetaminophen	acetaminophen	NOUN
admet-2626	78	42	,	,	PUNCT
admet-2626	78	43	crocetin	crocetin	NOUN
admet-2626	78	44	,	,	PUNCT
admet-2626	78	45	glibenclamide	glibenclamide	NOUN
admet-2626	78	46	,	,	PUNCT
admet-2626	78	47	indomethacin	indomethacin	PROPN
admet-2626	78	48	,	,	PUNCT
admet-2626	78	49	isotretinoin	isotretinoin	PROPN
admet-2626	78	50	,	,	PUNCT
admet-2626	78	51	naproxen	naproxen	NOUN
admet-2626	78	52	,	,	PUNCT
admet-2626	78	53	phenytoin	phenytoin	NOUN
admet-2626	78	54	,	,	PUNCT
admet-2626	78	55	and	and	CCONJ
admet-2626	78	56	quercetin	quercetin	NOUN
admet-2626	78	57	)	)	PUNCT
admet-2626	78	58	were	be	AUX
admet-2626	78	59	selected	select	VERB
admet-2626	78	60	.	.	PUNCT
admet-2626	79	1	the	the	DET
admet-2626	79	2	ten	ten	NUM
admet-2626	79	3	selected	select	VERB
admet-2626	79	4	weak	weak	ADJ
admet-2626	79	5	bases	basis	NOUN
admet-2626	79	6	include	include	VERB
admet-2626	79	7	atenolol	atenolol	PROPN
admet-2626	79	8	,	,	PUNCT
admet-2626	79	9	bedaquiline	bedaquiline	NOUN
admet-2626	79	10	,	,	PUNCT
admet-2626	79	11	brigatinib	brigatinib	NOUN
admet-2626	79	12	,	,	PUNCT
admet-2626	79	13	carvedilol	carvedilol	PROPN
admet-2626	79	14	,	,	PUNCT
admet-2626	79	15	emtricitabine	emtricitabine	NOUN
admet-2626	79	16	,	,	PUNCT
admet-2626	79	17	imatinib	imatinib	NOUN
admet-2626	79	18	,	,	PUNCT
admet-2626	79	19	imiquimod	imiquimod	ADJ
admet-2626	79	20	,	,	PUNCT
admet-2626	79	21	ketoconazole	ketoconazole	NOUN
admet-2626	79	22	,	,	PUNCT
admet-2626	79	23	lamotrigine	lamotrigine	NOUN
admet-2626	79	24	,	,	PUNCT
admet-2626	79	25	and	and	CCONJ
admet-2626	79	26	lumefanatrine	lumefanatrine	NOUN
admet-2626	79	27	.	.	PUNCT
admet-2626	80	1	the	the	DET
admet-2626	80	2	six	six	NUM
admet-2626	80	3	ampholytes	ampholyte	NOUN
admet-2626	80	4	considered	consider	VERB
admet-2626	80	5	are	be	AUX
admet-2626	80	6	celecoxib	celecoxib	VERB
admet-2626	80	7	,	,	PUNCT
admet-2626	80	8	enrofloxacin	enrofloxacin	PROPN
admet-2626	80	9	,	,	PUNCT
admet-2626	80	10	l	l	NOUN
admet-2626	80	11	-	-	NOUN
admet-2626	80	12	lysine	lysine	NOUN
admet-2626	80	13	,	,	PUNCT
admet-2626	80	14	mycophenolate	mycophenolate	PROPN
admet-2626	80	15	mofetil	mofetil	PROPN
admet-2626	80	16	,	,	PUNCT
admet-2626	80	17	piroxicam	piroxicam	ADJ
admet-2626	80	18	,	,	PUNCT
admet-2626	80	19	and	and	CCONJ
admet-2626	80	20	sulfamethoxazole	sulfamethoxazole	NOUN
admet-2626	80	21	.	.	PUNCT
admet-2626	81	1	values	value	NOUN
admet-2626	81	2	of	of	ADP
admet-2626	81	3	pka	pka	PROPN
admet-2626	81	4	were	be	AUX
admet-2626	81	5	taken	take	VERB
admet-2626	81	6	from	from	ADP
admet-2626	81	7	standard	standard	ADJ
admet-2626	81	8	compilations	compilation	NOUN
admet-2626	81	9	,	,	PUNCT
admet-2626	81	10	matching	match	VERB
admet-2626	81	11	the	the	DET
admet-2626	81	12	temperature	temperature	NOUN
admet-2626	81	13	of	of	ADP
admet-2626	81	14	the	the	DET
admet-2626	81	15	solubility	solubility	NOUN
admet-2626	81	16	measurements	measurement	NOUN
admet-2626	81	17	and	and	CCONJ
admet-2626	81	18	harmonizing	harmonize	VERB
admet-2626	81	19	on	on	ADP
admet-2626	81	20	ionic	ionic	ADJ
admet-2626	81	21	strengths	strength	NOUN
admet-2626	81	22	,	,	PUNCT
admet-2626	81	23	as	as	SCONJ
admet-2626	81	24	described	describe	VERB
admet-2626	81	25	below	below	ADP
admet-2626	81	26	[	[	PUNCT
admet-2626	81	27	28	28	NUM
admet-2626	81	28	-	-	SYM
admet-2626	81	29	34	34	NUM
admet-2626	81	30	]	]	PUNCT
admet-2626	81	31	.	.	PUNCT
admet-2626	82	1	for	for	ADP
admet-2626	82	2	newer	new	ADJ
admet-2626	82	3	drugs	drug	NOUN
admet-2626	82	4	,	,	PUNCT
admet-2626	82	5	relevant	relevant	ADJ
admet-2626	82	6	literature	literature	NOUN
admet-2626	82	7	sources	source	NOUN
admet-2626	82	8	were	be	AUX
admet-2626	82	9	consulted	consult	VERB
admet-2626	82	10	,	,	PUNCT
admet-2626	82	11	including	include	VERB
admet-2626	82	12	patents	patent	NOUN
admet-2626	82	13	and	and	CCONJ
admet-2626	82	14	public	public	ADJ
admet-2626	82	15	regulatory	regulatory	ADJ
admet-2626	82	16	agency	agency	NOUN
admet-2626	82	17	documents	document	NOUN
admet-2626	82	18	.	.	PUNCT
admet-2626	83	1	determination	determination	NOUN
admet-2626	83	2	of	of	ADP
admet-2626	83	3	equilibrium	equilibrium	NOUN
admet-2626	83	4	ph	ph	ADJ
admet-2626	83	5	and	and	CCONJ
admet-2626	83	6	intrinsic	intrinsic	ADJ
admet-2626	83	7	solubility	solubility	NOUN
admet-2626	83	8	the	the	DET
admet-2626	83	9	solubility	solubility	NOUN
admet-2626	83	10	analysis	analysis	NOUN
admet-2626	83	11	,	,	PUNCT
admet-2626	83	12	refinement	refinement	NOUN
admet-2626	83	13	,	,	PUNCT
admet-2626	83	14	and	and	CCONJ
admet-2626	83	15	simulation	simulation	NOUN
admet-2626	83	16	computer	computer	NOUN
admet-2626	83	17	program	program	NOUN
admet-2626	83	18	,	,	PUNCT
admet-2626	83	19	pdisol	pdisol	ADV
admet-2626	83	20	-	-	PUNCT
admet-2626	83	21	xtm	xtm	PROPN
admet-2626	83	22	(	(	PUNCT
admet-2626	83	23	in	in	ADP
admet-2626	83	24	-	-	PUNCT
admet-2626	83	25	adme	adme	NOUN
admet-2626	83	26	research	research	NOUN
admet-2626	83	27	)	)	PUNCT
admet-2626	83	28	,	,	PUNCT
admet-2626	83	29	was	be	AUX
admet-2626	83	30	used	use	VERB
admet-2626	83	31	in	in	ADP
admet-2626	83	32	this	this	DET
admet-2626	83	33	study	study	NOUN
admet-2626	83	34	.	.	PUNCT
admet-2626	84	1	the	the	DET
admet-2626	84	2	mathematical	mathematical	ADJ
admet-2626	84	3	approach	approach	NOUN
admet-2626	84	4	based	base	VERB
admet-2626	84	5	on	on	ADP
admet-2626	84	6	a	a	DET
admet-2626	84	7	mass	mass	ADJ
admet-2626	84	8	action	action	NOUN
admet-2626	84	9	equilibrium	equilibrium	NOUN
admet-2626	84	10	model	model	NOUN
admet-2626	84	11	continues	continue	VERB
admet-2626	84	12	to	to	PART
admet-2626	84	13	evolve	evolve	VERB
admet-2626	84	14	[	[	PUNCT
admet-2626	84	15	35	35	NUM
admet-2626	84	16	-	-	SYM
admet-2626	84	17	39	39	NUM
admet-2626	84	18	]	]	PUNCT
admet-2626	84	19	.	.	PUNCT
admet-2626	85	1	the	the	DET
admet-2626	85	2	program	program	NOUN
admet-2626	85	3	has	have	AUX
admet-2626	85	4	been	be	AUX
admet-2626	85	5	effectively	effectively	ADV
admet-2626	85	6	applied	apply	VERB
admet-2626	85	7	in	in	ADP
admet-2626	85	8	several	several	ADJ
admet-2626	85	9	studies	study	NOUN
admet-2626	85	10	involving	involve	VERB
admet-2626	85	11	multifactorial	multifactorial	ADJ
admet-2626	85	12	equilibria	equilibrium	NOUN
admet-2626	85	13	:	:	PUNCT
admet-2626	85	14	self	self	NOUN
admet-2626	85	15	-	-	PUNCT
admet-2626	85	16	aggregation	aggregation	NOUN
admet-2626	86	1	[	[	X
admet-2626	86	2	40	40	NUM
admet-2626	86	3	-	-	SYM
admet-2626	86	4	45	45	NUM
admet-2626	86	5	]	]	PUNCT
admet-2626	86	6	,	,	PUNCT
admet-2626	86	7	cocrystals	cocrystal	NOUN
admet-2626	86	8	[	[	X
admet-2626	86	9	46	46	NUM
admet-2626	86	10	-	-	SYM
admet-2626	86	11	48	48	NUM
admet-2626	86	12	]	]	PUNCT
admet-2626	86	13	,	,	PUNCT
admet-2626	86	14	complexation	complexation	NOUN
admet-2626	86	15	[	[	X
admet-2626	86	16	49,50	49,50	X
admet-2626	86	17	]	]	X
admet-2626	86	18	,	,	PUNCT
admet-2626	86	19	and	and	CCONJ
admet-2626	86	20	salt	salt	NOUN
admet-2626	86	21	disproportionation	disproportionation	NOUN
admet-2626	86	22	[	[	X
admet-2626	86	23	51,52	51,52	NUM
admet-2626	86	24	]	]	PUNCT
admet-2626	86	25	.	.	PUNCT
admet-2626	87	1	recently	recently	ADV
admet-2626	87	2	,	,	PUNCT
admet-2626	87	3	salting	salt	VERB
admet-2626	87	4	-	-	PUNCT
admet-2626	87	5	out	out	ADP
admet-2626	87	6	activity	activity	NOUN
admet-2626	87	7	corrections	correction	NOUN
admet-2626	87	8	have	have	AUX
admet-2626	87	9	been	be	AUX
admet-2626	87	10	added	add	VERB
admet-2626	87	11	[	[	X
admet-2626	87	12	15	15	NUM
admet-2626	87	13	]	]	PUNCT
admet-2626	87	14	.	.	PUNCT
admet-2626	88	1	the	the	DET
admet-2626	88	2	data	data	NOUN
admet-2626	88	3	analysis	analysis	NOUN
admet-2626	88	4	method	method	NOUN
admet-2626	88	5	uses	use	VERB
admet-2626	88	6	log	log	NOUN
admet-2626	88	7	s	s	PART
admet-2626	88	8	(	(	PUNCT
admet-2626	88	9	molarity	molarity	NOUN
admet-2626	88	10	basis	basis	NOUN
admet-2626	88	11	)	)	PUNCT
admet-2626	88	12	as	as	ADP
admet-2626	88	13	measured	measure	VERB
admet-2626	88	14	input	input	NOUN
admet-2626	88	15	data	datum	NOUN
admet-2626	88	16	,	,	PUNCT
admet-2626	88	17	as	as	ADP
admet-2626	88	18	a	a	DET
admet-2626	88	19	function	function	NOUN
admet-2626	88	20	of	of	ADP
admet-2626	88	21	ph	ph	PROPN
admet-2626	88	22	.	.	PUNCT
admet-2626	89	1	the	the	DET
admet-2626	89	2	analytical	analytical	ADJ
admet-2626	89	3	concentrations	concentration	NOUN
admet-2626	89	4	of	of	ADP
admet-2626	89	5	all	all	DET
admet-2626	89	6	added	add	VERB
admet-2626	89	7	reagents	reagent	NOUN
admet-2626	89	8	are	be	AUX
admet-2626	89	9	specified	specify	VERB
admet-2626	89	10	.	.	PUNCT
admet-2626	90	1	the	the	DET
admet-2626	90	2	mass	mass	ADJ
admet-2626	90	3	action	action	NOUN
admet-2626	90	4	algorithm	algorithm	NOUN
admet-2626	90	5	considers	consider	VERB
admet-2626	90	6	the	the	DET
admet-2626	90	7	contribution	contribution	NOUN
admet-2626	90	8	of	of	ADP
admet-2626	90	9	all	all	DET
admet-2626	90	10	species	specie	NOUN
admet-2626	90	11	proposed	propose	VERB
admet-2626	90	12	to	to	PART
admet-2626	90	13	be	be	AUX
admet-2626	90	14	present	present	ADJ
admet-2626	90	15	in	in	ADP
admet-2626	90	16	the	the	DET
admet-2626	90	17	solution	solution	NOUN
admet-2626	90	18	.	.	PUNCT
admet-2626	91	1	the	the	DET
admet-2626	91	2	algorithm	algorithm	NOUN
admet-2626	91	3	derives	derive	VERB
admet-2626	91	4	its	its	PRON
admet-2626	91	5	own	own	ADJ
admet-2626	91	6	implicit	implicit	ADJ
admet-2626	91	7	polynomial	polynomial	ADJ
admet-2626	91	8	equations	equation	NOUN
admet-2626	91	9	internally	internally	ADV
admet-2626	91	10	,	,	PUNCT
admet-2626	91	11	given	give	VERB
admet-2626	91	12	a	a	DET
admet-2626	91	13	practical	practical	ADJ
admet-2626	91	14	number	number	NOUN
admet-2626	91	15	of	of	ADP
admet-2626	91	16	equilibrium	equilibrium	NOUN
admet-2626	91	17	reactions	reaction	NOUN
admet-2626	91	18	and	and	CCONJ
admet-2626	91	19	the	the	DET
admet-2626	91	20	corresponding	correspond	VERB
admet-2626	91	21	roughly	roughly	ADV
admet-2626	91	22	estimated	estimate	VERB
admet-2626	91	23	constants	constant	NOUN
admet-2626	91	24	.	.	PUNCT
admet-2626	92	1	the	the	DET
admet-2626	92	2	program	program	NOUN
admet-2626	92	3	refines	refine	VERB
admet-2626	92	4	the	the	DET
admet-2626	92	5	estimated	estimate	VERB
admet-2626	92	6	constants	constant	NOUN
admet-2626	92	7	and	and	CCONJ
admet-2626	92	8	calculates	calculate	VERB
admet-2626	92	9	the	the	DET
admet-2626	92	10	distribution	distribution	NOUN
admet-2626	92	11	of	of	ADP
admet-2626	92	12	species	specie	NOUN
admet-2626	92	13	and	and	CCONJ
admet-2626	92	14	reactants	reactant	NOUN
admet-2626	92	15	consequent	consequent	ADJ
admet-2626	92	16	to	to	ADP
admet-2626	92	17	a	a	DET
admet-2626	92	18	simulated	simulate	VERB
admet-2626	92	19	sequence	sequence	NOUN
admet-2626	92	20	of	of	ADP
admet-2626	92	21	additions	addition	NOUN
admet-2626	92	22	of	of	ADP
admet-2626	92	23	titrant	titrant	NOUN
admet-2626	92	24	(	(	PUNCT
admet-2626	92	25	e.g.	e.g.	ADV
admet-2626	92	26	hcl	hcl	PROPN
admet-2626	92	27	or	or	CCONJ
admet-2626	92	28	naoh	naoh	NOUN
admet-2626	92	29	,	,	PUNCT
admet-2626	92	30	or	or	CCONJ
admet-2626	92	31	a	a	DET
admet-2626	92	32	few	few	ADJ
admet-2626	92	33	program	program	NOUN
admet-2626	92	34	-	-	PUNCT
admet-2626	92	35	recognized	recognize	VERB
admet-2626	92	36	ionizable	ionizable	ADJ
admet-2626	92	37	titrants	titrant	NOUN
admet-2626	92	38	:	:	PUNCT
admet-2626	92	39	phosphoric	phosphoric	NOUN
admet-2626	92	40	acid	acid	NOUN
admet-2626	92	41	,	,	PUNCT
admet-2626	92	42	maleic	maleic	VERB
admet-2626	92	43	acid	acid	NOUN
admet-2626	92	44	,	,	PUNCT
admet-2626	92	45	lysine	lysine	NOUN
admet-2626	92	46	,	,	PUNCT
admet-2626	92	47	etc	etc	X
admet-2626	92	48	.	.	X
admet-2626	92	49	)	)	PUNCT
admet-2626	92	50	,	,	PUNCT
admet-2626	92	51	to	to	PART
admet-2626	92	52	simulate	simulate	VERB
admet-2626	92	53	the	the	DET
admet-2626	92	54	suspension	suspension	NOUN
admet-2626	92	55	ph	ph	NOUN
admet-2626	92	56	speciation	speciation	NOUN
admet-2626	92	57	from	from	ADP
admet-2626	92	58	ph	ph	PROPN
admet-2626	92	59	0	0	NUM
admet-2626	92	60	to	to	ADP
admet-2626	92	61	13	13	NUM
admet-2626	92	62	.	.	PUNCT
admet-2626	93	1	the	the	DET
admet-2626	93	2	ionic	ionic	ADJ
admet-2626	93	3	strength	strength	NOUN
admet-2626	93	4	,	,	PUNCT
admet-2626	93	5	i	i	PRON
admet-2626	93	6	,	,	PUNCT
admet-2626	93	7	is	be	AUX
admet-2626	93	8	iteratively	iteratively	ADV
admet-2626	93	9	calculated	calculate	VERB
admet-2626	93	10	at	at	ADP
admet-2626	93	11	each	each	DET
admet-2626	93	12	ph	ph	PROPN
admet-2626	93	13	.	.	PROPN
admet-2626	93	14	values	value	NOUN
admet-2626	93	15	of	of	ADP
admet-2626	93	16	pka	pka	PROPN
admet-2626	93	17	,	,	PUNCT
admet-2626	93	18	intrinsic	intrinsic	ADJ
admet-2626	93	19	solubility	solubility	NOUN
admet-2626	93	20	,	,	PUNCT
admet-2626	93	21	along	along	ADP
admet-2626	93	22	with	with	ADP
admet-2626	93	23	ph	ph	ADJ
admet-2626	93	24	electrode	electrode	NOUN
admet-2626	93	25	standardization	standardization	NOUN
admet-2626	93	26	constants	constant	NOUN
admet-2626	93	27	,	,	PUNCT
admet-2626	93	28	are	be	AUX
admet-2626	93	29	accordingly	accordingly	ADV
admet-2626	93	30	adjusted	adjust	VERB
admet-2626	93	31	at	at	ADP
admet-2626	93	32	each	each	DET
admet-2626	93	33	ph	ph	NOUN
admet-2626	93	34	point	point	NOUN
admet-2626	93	35	for	for	ADP
admet-2626	93	36	activity	activity	NOUN
admet-2626	93	37	deviations	deviation	NOUN
admet-2626	93	38	from	from	ADP
admet-2626	93	39	the	the	DET
admet-2626	93	40	benchmark	benchmark	ADJ
admet-2626	93	41	level	level	NOUN
admet-2626	93	42	of	of	ADP
admet-2626	93	43	iref	iref	NOUN
admet-2626	93	44	=	=	PUNCT
admet-2626	93	45	0.15	0.15	NUM
admet-2626	93	46	m	m	PROPN
admet-2626	93	47	,	,	PUNCT
admet-2626	93	48	selected	select	VERB
admet-2626	93	49	as	as	ADP
admet-2626	93	50	the	the	DET
admet-2626	93	51	basis	basis	NOUN
admet-2626	93	52	of	of	ADP
admet-2626	93	53	the	the	DET
admet-2626	93	54	‘	'	PUNCT
admet-2626	93	55	constant	constant	ADJ
admet-2626	93	56	ionic	ionic	ADJ
admet-2626	93	57	medium	medium	ADJ
admet-2626	93	58	’	'	PUNCT
admet-2626	93	59	thermodynamic	thermodynamic	ADJ
admet-2626	93	60	state	state	NOUN
admet-2626	94	1	[	[	X
admet-2626	94	2	12	12	NUM
admet-2626	94	3	]	]	PUNCT
admet-2626	94	4	.	.	PUNCT
admet-2626	95	1	all	all	DET
admet-2626	95	2	the	the	DET
admet-2626	95	3	equilibrium	equilibrium	NOUN
admet-2626	95	4	constants	constant	NOUN
admet-2626	95	5	reported	report	VERB
admet-2626	95	6	here	here	ADV
admet-2626	95	7	are	be	AUX
admet-2626	95	8	based	base	VERB
admet-2626	95	9	on	on	ADP
admet-2626	95	10	the	the	DET
admet-2626	95	11	concentration	concentration	NOUN
admet-2626	95	12	scale	scale	NOUN
admet-2626	95	13	,	,	PUNCT
admet-2626	95	14	i.e.	i.e.	X
admet-2626	95	15	the	the	DET
admet-2626	95	16	‘	'	PUNCT
admet-2626	95	17	constant	constant	ADJ
admet-2626	95	18	ionic	ionic	ADJ
admet-2626	95	19	medium	medium	ADJ
admet-2626	95	20	’	'	PUNCT
admet-2626	95	21	thermodynamic	thermodynamic	ADJ
admet-2626	95	22	standard	standard	ADJ
admet-2626	95	23	state	state	NOUN
admet-2626	95	24	,	,	PUNCT
admet-2626	95	25	without	without	ADP
admet-2626	95	26	loss	loss	NOUN
admet-2626	95	27	of	of	ADP
admet-2626	95	28	thermodynamic	thermodynamic	ADJ
admet-2626	95	29	rigor	rigor	NOUN
admet-2626	96	1	[	[	X
admet-2626	96	2	12	12	NUM
admet-2626	96	3	]	]	PUNCT
admet-2626	96	4	(	(	PUNCT
admet-2626	96	5	pp	pp	ADJ
admet-2626	96	6	.	.	PUNCT
admet-2626	97	1	43	43	NUM
admet-2626	97	2	-	-	SYM
admet-2626	97	3	47	47	NUM
admet-2626	97	4	)	)	PUNCT
admet-2626	97	5	.	.	PUNCT
admet-2626	98	1	since	since	SCONJ
admet-2626	98	2	the	the	DET
admet-2626	98	3	measured	measured	ADJ
admet-2626	98	4	ph	ph	NOUN
admet-2626	98	5	is	be	AUX
admet-2626	98	6	based	base	VERB
admet-2626	98	7	on	on	ADP
admet-2626	98	8	the	the	DET
admet-2626	98	9	‘	'	PUNCT
admet-2626	98	10	operational	operational	ADJ
admet-2626	98	11	’	'	PUNCT
admet-2626	98	12	activity	activity	NOUN
admet-2626	98	13	scale	scale	NOUN
admet-2626	98	14	(	(	PUNCT
admet-2626	98	15	pah	pah	PROPN
admet-2626	98	16	)	)	PUNCT
admet-2626	98	17	,	,	PUNCT
admet-2626	98	18	such	such	ADJ
admet-2626	98	19	values	value	NOUN
admet-2626	98	20	need	need	VERB
admet-2626	98	21	to	to	PART
admet-2626	98	22	be	be	AUX
admet-2626	98	23	converted	convert	VERB
admet-2626	98	24	to	to	ADP
admet-2626	98	25	the	the	DET
admet-2626	98	26	concentration	concentration	NOUN
admet-2626	98	27	scale	scale	NOUN
admet-2626	98	28	,	,	PUNCT
admet-2626	98	29	pch	pch	ADJ
admet-2626	98	30	(=	(=	X
admet-2626	98	31	-log	-log	X
admet-2626	98	32	ch+	ch+	PROPN
admet-2626	98	33	)	)	PUNCT
admet-2626	98	34	,	,	PUNCT
admet-2626	98	35	as	as	SCONJ
admet-2626	98	36	described	describe	VERB
admet-2626	98	37	elsewhere	elsewhere	ADV
admet-2626	98	38	[	[	X
admet-2626	98	39	12	12	NUM
admet-2626	98	40	]	]	PUNCT
admet-2626	98	41	(	(	PUNCT
admet-2626	98	42	pp	pp	ADJ
admet-2626	98	43	.	.	PUNCT
admet-2626	99	1	55	55	NUM
admet-2626	99	2	-	-	SYM
admet-2626	99	3	66	66	NUM
admet-2626	99	4	;	;	PUNCT
admet-2626	99	5	cf	cf	X
admet-2626	99	6	.	.	PUNCT
admet-2626	100	1	appendix	appendix	PROPN
admet-2626	100	2	b	b	NOUN
admet-2626	100	3	)	)	PUNCT
admet-2626	100	4	.	.	PUNCT
admet-2626	101	1	in	in	ADP
admet-2626	101	2	such	such	DET
admet-2626	101	3	a	a	DET
admet-2626	101	4	system	system	NOUN
admet-2626	101	5	,	,	PUNCT
admet-2626	101	6	the	the	DET
admet-2626	101	7	electrode	electrode	NOUN
admet-2626	101	8	is	be	AUX
admet-2626	101	9	first	first	ADV
admet-2626	101	10	‘	'	PUNCT
admet-2626	101	11	calibrated	calibrate	VERB
admet-2626	101	12	’	'	PUNCT
admet-2626	101	13	using	use	VERB
admet-2626	101	14	nist	nist	NOUN
admet-2626	101	15	standard	standard	ADJ
admet-2626	101	16	ph	ph	ADJ
admet-2626	101	17	buffers	buffer	NOUN
admet-2626	101	18	,	,	PUNCT
admet-2626	101	19	which	which	PRON
admet-2626	101	20	establishes	establish	VERB
admet-2626	101	21	the	the	DET
admet-2626	101	22	relationship	relationship	NOUN
admet-2626	101	23	between	between	ADP
admet-2626	101	24	meter	meter	NOUN
admet-2626	101	25	voltage	voltage	NOUN
admet-2626	101	26	(	(	PUNCT
admet-2626	101	27	mv	mv	NOUN
admet-2626	101	28	)	)	PUNCT
admet-2626	101	29	readings	reading	NOUN
admet-2626	101	30	and	and	CCONJ
admet-2626	101	31	the	the	DET
admet-2626	101	32	pah	pah	PROPN
admet-2626	101	33	scale	scale	NOUN
admet-2626	101	34	.	.	PUNCT
admet-2626	102	1	these	these	DET
admet-2626	102	2	values	value	NOUN
admet-2626	102	3	are	be	AUX
admet-2626	102	4	then	then	ADV
admet-2626	102	5	converted	convert	VERB
admet-2626	102	6	into	into	ADP
admet-2626	102	7	the	the	DET
admet-2626	102	8	pch	pch	ADJ
admet-2626	102	9	scale	scale	NOUN
admet-2626	102	10	.	.	PUNCT
admet-2626	103	1	since	since	SCONJ
admet-2626	103	2	i	i	PRON
admet-2626	103	3	at	at	ADP
admet-2626	103	4	any	any	DET
admet-2626	103	5	given	give	VERB
admet-2626	103	6	ph	ph	ADJ
admet-2626	103	7	point	point	NOUN
admet-2626	103	8	in	in	ADP
admet-2626	103	9	an	an	DET
admet-2626	103	10	acid	acid	NOUN
admet-2626	103	11	-	-	PUNCT
admet-2626	103	12	base	base	NOUN
admet-2626	103	13	titration	titration	NOUN
admet-2626	103	14	is	be	AUX
admet-2626	103	15	likely	likely	ADJ
admet-2626	103	16	to	to	PART
admet-2626	103	17	be	be	AUX
admet-2626	103	18	different	different	ADJ
admet-2626	103	19	from	from	ADP
admet-2626	103	20	iref	iref	NOUN
admet-2626	103	21	,	,	PUNCT
admet-2626	103	22	all	all	DET
admet-2626	103	23	ionization	ionization	NOUN
admet-2626	103	24	constants	constant	NOUN
admet-2626	103	25	are	be	AUX
admet-2626	103	26	locally	locally	ADV
admet-2626	103	27	transformed	transform	VERB
admet-2626	103	28	(	(	PUNCT
admet-2626	103	29	from	from	ADP
admet-2626	103	30	iref	iref	NOUN
admet-2626	103	31	to	to	ADP
admet-2626	103	32	local	local	ADJ
admet-2626	103	33	i	i	PROPN
admet-2626	103	34	)	)	PUNCT
admet-2626	103	35	for	for	ADP
admet-2626	103	36	the	the	DET
admet-2626	103	37	calculation	calculation	NOUN
admet-2626	103	38	of	of	ADP
admet-2626	103	39	local	local	ADJ
admet-2626	103	40	point	point	NOUN
admet-2626	103	41	concentrations	concentration	NOUN
admet-2626	103	42	(	(	PUNCT
admet-2626	103	43	as	as	SCONJ
admet-2626	103	44	detailed	detailed	ADJ
admet-2626	103	45	in	in	ADP
admet-2626	103	46	supplementary	supplementary	ADJ
admet-2626	103	47	material	material	NOUN
admet-2626	103	48	,	,	PUNCT
admet-2626	103	49	appendix	appendix	VERB
admet-2626	103	50	a	a	PRON
admet-2626	103	51	)	)	PUNCT
admet-2626	103	52	.	.	PUNCT
admet-2626	104	1	it	it	PRON
admet-2626	104	2	is	be	AUX
admet-2626	104	3	a	a	DET
admet-2626	104	4	reasonable	reasonable	ADJ
admet-2626	104	5	practice	practice	NOUN
admet-2626	104	6	to	to	PART
admet-2626	104	7	designate	designate	VERB
admet-2626	104	8	0.15	0.15	NUM
admet-2626	104	9	m	m	NOUN
admet-2626	104	10	as	as	ADP
admet-2626	104	11	the	the	DET
admet-2626	104	12	benchmark	benchmark	NOUN
admet-2626	104	13	‘	'	PUNCT
admet-2626	104	14	reference	reference	NOUN
admet-2626	104	15	’	'	PUNCT
admet-2626	104	16	ionic	ionic	ADJ
admet-2626	104	17	strength	strength	NOUN
admet-2626	104	18	,	,	PUNCT
admet-2626	104	19	iref	iref	NOUN
admet-2626	104	20	(	(	PUNCT
admet-2626	104	21	‘	'	PUNCT
admet-2626	104	22	physiological	physiological	ADJ
admet-2626	104	23	’	'	PUNCT
admet-2626	104	24	level	level	NOUN
admet-2626	104	25	)	)	PUNCT
admet-2626	104	26	,	,	PUNCT
admet-2626	104	27	to	to	PART
admet-2626	104	28	which	which	PRON
admet-2626	104	29	all	all	DET
admet-2626	104	30	equilibrium	equilibrium	NOUN
admet-2626	104	31	constants	constant	NOUN
admet-2626	104	32	are	be	AUX
admet-2626	104	33	harmonized	harmonize	VERB
admet-2626	104	34	in	in	ADP
admet-2626	104	35	the	the	DET
admet-2626	104	36	data	datum	NOUN
admet-2626	104	37	analysis	analysis	NOUN
admet-2626	104	38	.	.	PUNCT
admet-2626	105	1	the	the	DET
admet-2626	105	2	procedure	procedure	NOUN
admet-2626	105	3	uses	use	VERB
admet-2626	105	4	activity	activity	NOUN
admet-2626	105	5	corrections	correction	NOUN
admet-2626	105	6	based	base	VERB
admet-2626	105	7	on	on	ADP
admet-2626	105	8	the	the	DET
admet-2626	105	9	hydration	hydration	NOUN
admet-2626	105	10	theory	theory	NOUN
admet-2626	105	11	proposed	propose	VERB
admet-2626	105	12	by	by	ADP
admet-2626	105	13	stokes	stoke	NOUN
admet-2626	105	14	and	and	CCONJ
admet-2626	105	15	robinson	robinson	PROPN
admet-2626	106	1	[	[	X
admet-2626	106	2	13,14,53	13,14,53	NUM
admet-2626	106	3	-	-	SYM
admet-2626	106	4	55	55	NUM
admet-2626	106	5	]	]	PUNCT
admet-2626	106	6	,	,	PUNCT
admet-2626	106	7	as	as	SCONJ
admet-2626	106	8	described	describe	VERB
admet-2626	106	9	by	by	ADP
admet-2626	106	10	examples	example	NOUN
admet-2626	106	11	in	in	ADP
admet-2626	106	12	the	the	DET
admet-2626	106	13	next	next	ADJ
admet-2626	106	14	four	four	NUM
admet-2626	106	15	sections	section	NOUN
admet-2626	106	16	and	and	CCONJ
admet-2626	106	17	in	in	ADP
admet-2626	106	18	further	further	ADJ
admet-2626	106	19	detail	detail	NOUN
admet-2626	106	20	in	in	ADP
admet-2626	106	21	appendix	appendix	ADJ
admet-2626	106	22	a.	a.	NOUN
admet-2626	106	23	admet	admet	PROPN
admet-2626	106	24	&	&	CCONJ
admet-2626	106	25	dmpk	dmpk	PROPN
admet-2626	106	26	13(1	13(1	NUM
admet-2626	106	27	)	)	PUNCT
admet-2626	106	28	(	(	PUNCT
admet-2626	106	29	2025	2025	NUM
admet-2626	106	30	)	)	PUNCT
admet-2626	106	31	2626	2626	NUM
admet-2626	106	32	transforming	transform	VERB
admet-2626	106	33	drug	drug	NOUN
admet-2626	106	34	solubility	solubility	NOUN
admet-2626	106	35	measurement	measurement	NOUN
admet-2626	106	36	doi	doi	PROPN
admet-2626	106	37	:	:	PUNCT
admet-2626	106	38	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	106	39	5	5	NUM
admet-2626	106	40	stokes	stokes	PROPN
admet-2626	106	41	-	-	PUNCT
admet-2626	106	42	robinson	robinson	PROPN
admet-2626	106	43	hydration	hydration	NOUN
admet-2626	106	44	theory	theory	NOUN
admet-2626	106	45	modified	modify	VERB
admet-2626	106	46	to	to	PART
admet-2626	106	47	better	well	ADV
admet-2626	106	48	account	account	VERB
admet-2626	106	49	for	for	ADP
admet-2626	106	50	the	the	DET
admet-2626	106	51	activity	activity	NOUN
admet-2626	106	52	corrections	correction	NOUN
admet-2626	106	53	of	of	ADP
admet-2626	106	54	uncharged	uncharged	ADJ
admet-2626	106	55	molecules	molecule	NOUN
admet-2626	106	56	activity	activity	NOUN
admet-2626	106	57	corrections	correction	NOUN
admet-2626	106	58	using	use	VERB
admet-2626	106	59	the	the	DET
admet-2626	106	60	stokes	stokes	PROPN
admet-2626	106	61	-	-	PUNCT
admet-2626	106	62	robinson	robinson	PROPN
admet-2626	106	63	hydration	hydration	NOUN
admet-2626	106	64	theory	theory	NOUN
admet-2626	106	65	model	model	NOUN
admet-2626	106	66	(	(	PUNCT
admet-2626	106	67	srht	srht	NOUN
admet-2626	106	68	)	)	PUNCT
admet-2626	107	1	[	[	X
admet-2626	107	2	13	13	NUM
admet-2626	107	3	]	]	PUNCT
admet-2626	107	4	have	have	AUX
admet-2626	107	5	seldom	seldom	ADV
admet-2626	107	6	been	be	AUX
admet-2626	107	7	applied	apply	VERB
admet-2626	107	8	in	in	ADP
admet-2626	107	9	solution	solution	NOUN
admet-2626	107	10	speciation	speciation	NOUN
admet-2626	107	11	studies	study	NOUN
admet-2626	107	12	involving	involve	VERB
admet-2626	107	13	multiprotic	multiprotic	ADJ
admet-2626	107	14	drugs	drug	NOUN
admet-2626	107	15	in	in	ADP
admet-2626	107	16	media	medium	NOUN
admet-2626	107	17	containing	contain	VERB
admet-2626	107	18	numerous	numerous	ADJ
admet-2626	107	19	charged	charge	VERB
admet-2626	107	20	and	and	CCONJ
admet-2626	107	21	neutral	neutral	ADJ
admet-2626	107	22	species	specie	NOUN
admet-2626	107	23	.	.	PUNCT
admet-2626	108	1	one	one	NUM
admet-2626	108	2	exception	exception	NOUN
admet-2626	108	3	appears	appear	VERB
admet-2626	108	4	to	to	PART
admet-2626	108	5	be	be	AUX
admet-2626	108	6	that	that	PRON
admet-2626	108	7	of	of	ADP
admet-2626	108	8	wang	wang	PROPN
admet-2626	108	9	et	et	PROPN
admet-2626	108	10	al	al	PROPN
admet-2626	108	11	.	.	PUNCT
admet-2626	109	1	[	[	X
admet-2626	109	2	14	14	NUM
admet-2626	109	3	]	]	PUNCT
admet-2626	109	4	.	.	PUNCT
admet-2626	110	1	we	we	PRON
admet-2626	110	2	adapted	adapt	VERB
admet-2626	110	3	the	the	DET
admet-2626	110	4	version	version	NOUN
admet-2626	110	5	detailed	detail	VERB
admet-2626	110	6	by	by	ADP
admet-2626	110	7	wang	wang	PROPN
admet-2626	110	8	et	et	PROPN
admet-2626	110	9	al	al	PROPN
admet-2626	110	10	.	.	PROPN
admet-2626	111	1	into	into	ADP
admet-2626	111	2	pdisol	pdisol	ADJ
admet-2626	111	3	-	-	PUNCT
admet-2626	111	4	x	x	NOUN
admet-2626	111	5	in	in	ADP
admet-2626	111	6	2013	2013	NUM
admet-2626	111	7	[	[	X
admet-2626	111	8	40	40	NUM
admet-2626	111	9	]	]	PUNCT
admet-2626	111	10	and	and	CCONJ
admet-2626	111	11	continue	continue	VERB
admet-2626	111	12	to	to	PART
admet-2626	111	13	make	make	VERB
admet-2626	111	14	slight	slight	ADJ
admet-2626	111	15	improvements	improvement	NOUN
admet-2626	111	16	to	to	ADP
admet-2626	111	17	the	the	DET
admet-2626	111	18	treatment	treatment	NOUN
admet-2626	111	19	.	.	PUNCT
admet-2626	112	1	in	in	ADP
admet-2626	112	2	many	many	ADJ
admet-2626	112	3	of	of	ADP
admet-2626	112	4	the	the	DET
admet-2626	112	5	classical	classical	ADJ
admet-2626	112	6	papers	paper	NOUN
admet-2626	112	7	embracing	embrace	VERB
admet-2626	112	8	the	the	DET
admet-2626	112	9	srht	srht	NOUN
admet-2626	112	10	method	method	NOUN
admet-2626	112	11	,	,	PUNCT
admet-2626	112	12	most	most	ADJ
admet-2626	112	13	of	of	ADP
admet-2626	112	14	the	the	DET
admet-2626	112	15	emphasis	emphasis	NOUN
admet-2626	112	16	has	have	AUX
admet-2626	112	17	been	be	AUX
admet-2626	112	18	placed	place	VERB
admet-2626	112	19	on	on	ADP
admet-2626	112	20	correcting	correct	VERB
admet-2626	112	21	the	the	DET
admet-2626	112	22	activity	activity	NOUN
admet-2626	112	23	of	of	ADP
admet-2626	112	24	charged	charge	VERB
admet-2626	112	25	species	specie	NOUN
admet-2626	112	26	,	,	PUNCT
admet-2626	112	27	since	since	SCONJ
admet-2626	112	28	long	long	ADJ
admet-2626	112	29	-	-	PUNCT
admet-2626	112	30	range	range	NOUN
admet-2626	112	31	ion	ion	NOUN
admet-2626	112	32	-	-	PUNCT
admet-2626	112	33	ion	ion	NOUN
admet-2626	112	34	interactions	interaction	NOUN
admet-2626	112	35	play	play	VERB
admet-2626	112	36	a	a	DET
admet-2626	112	37	dominant	dominant	ADJ
admet-2626	112	38	role	role	NOUN
admet-2626	112	39	in	in	ADP
admet-2626	112	40	solutions	solution	NOUN
admet-2626	112	41	with	with	ADP
admet-2626	112	42	i	i	PRON
admet-2626	112	43	<	<	X
admet-2626	112	44	0.5	0.5	NUM
admet-2626	112	45	m	m	NOUN
admet-2626	112	46	,	,	PUNCT
admet-2626	112	47	in	in	ADP
admet-2626	112	48	comparison	comparison	NOUN
admet-2626	112	49	to	to	ADP
admet-2626	112	50	the	the	DET
admet-2626	112	51	effect	effect	NOUN
admet-2626	112	52	of	of	ADP
admet-2626	112	53	short	short	ADJ
admet-2626	112	54	-	-	PUNCT
admet-2626	112	55	range	range	NOUN
admet-2626	112	56	ion	ion	NOUN
admet-2626	112	57	-	-	PUNCT
admet-2626	112	58	solvent	solvent	NOUN
admet-2626	112	59	interactions	interaction	NOUN
admet-2626	112	60	.	.	PUNCT
admet-2626	113	1	activity	activity	NOUN
admet-2626	113	2	corrections	correction	NOUN
admet-2626	113	3	for	for	ADP
admet-2626	113	4	neutral	neutral	ADJ
admet-2626	113	5	species	specie	NOUN
admet-2626	113	6	are	be	AUX
admet-2626	113	7	seldom	seldom	ADV
admet-2626	113	8	discussed	discuss	VERB
admet-2626	113	9	in	in	ADP
admet-2626	113	10	the	the	DET
admet-2626	113	11	context	context	NOUN
admet-2626	113	12	of	of	ADP
admet-2626	113	13	srht	srht	PROPN
admet-2626	113	14	model	model	PROPN
admet-2626	113	15	.	.	PUNCT
admet-2626	114	1	there	there	PRON
admet-2626	114	2	are	be	VERB
admet-2626	114	3	three	three	NUM
admet-2626	114	4	components	component	NOUN
admet-2626	114	5	to	to	ADP
admet-2626	114	6	the	the	DET
admet-2626	114	7	model	model	NOUN
admet-2626	114	8	(	(	PUNCT
admet-2626	114	9	eq	eq	NOUN
admet-2626	114	10	.	.	NOUN
admet-2626	114	11	a4	a4	NOUN
admet-2626	114	12	in	in	ADP
admet-2626	114	13	appendix	appendix	NOUN
admet-2626	114	14	a	a	PRON
admet-2626	114	15	)	)	PUNCT
admet-2626	114	16	.	.	PUNCT
admet-2626	115	1	the	the	DET
admet-2626	115	2	first	first	ADJ
admet-2626	115	3	term	term	NOUN
admet-2626	115	4	in	in	ADP
admet-2626	115	5	eq	eq	ADP
admet-2626	115	6	.	.	NOUN
admet-2626	115	7	a4	a4	NOUN
admet-2626	115	8	addresses	address	NOUN
admet-2626	115	9	the	the	DET
admet-2626	115	10	dominant	dominant	ADJ
admet-2626	115	11	ion	ion	NOUN
admet-2626	115	12	-	-	PUNCT
admet-2626	115	13	ion	ion	NOUN
admet-2626	115	14	electrostatic	electrostatic	ADJ
admet-2626	115	15	interactions	interaction	NOUN
admet-2626	115	16	.	.	PUNCT
admet-2626	116	1	the	the	DET
admet-2626	116	2	impact	impact	NOUN
admet-2626	116	3	of	of	ADP
admet-2626	116	4	the	the	DET
admet-2626	116	5	srht	srht	NOUN
admet-2626	116	6	model	model	NOUN
admet-2626	116	7	on	on	ADP
admet-2626	116	8	uncharged	uncharged	ADJ
admet-2626	116	9	species	specie	NOUN
admet-2626	116	10	arises	arise	VERB
admet-2626	116	11	from	from	ADP
admet-2626	116	12	the	the	DET
admet-2626	116	13	second	second	ADJ
admet-2626	116	14	and	and	CCONJ
admet-2626	116	15	third	third	ADJ
admet-2626	116	16	‘	'	PUNCT
admet-2626	116	17	solvation	solvation	NOUN
admet-2626	116	18	’	'	PUNCT
admet-2626	116	19	terms	term	NOUN
admet-2626	116	20	in	in	ADP
admet-2626	116	21	eq	eq	NOUN
admet-2626	116	22	.	.	NOUN
admet-2626	116	23	a4	a4	NOUN
admet-2626	116	24	(	(	PUNCT
admet-2626	116	25	ion	ion	NOUN
admet-2626	116	26	-	-	PUNCT
admet-2626	116	27	solvent	solvent	NOUN
admet-2626	116	28	interactions	interaction	NOUN
admet-2626	116	29	)	)	PUNCT
admet-2626	116	30	,	,	PUNCT
admet-2626	116	31	although	although	SCONJ
admet-2626	116	32	the	the	DET
admet-2626	116	33	calculated	calculate	VERB
admet-2626	116	34	activity	activity	NOUN
admet-2626	116	35	coefficients	coefficient	NOUN
admet-2626	116	36	are	be	AUX
admet-2626	116	37	practically	practically	ADV
admet-2626	116	38	unit	unit	NOUN
admet-2626	116	39	value	value	NOUN
admet-2626	116	40	in	in	ADP
admet-2626	116	41	the	the	DET
admet-2626	116	42	model	model	NOUN
admet-2626	116	43	,	,	PUNCT
admet-2626	116	44	unless	unless	SCONJ
admet-2626	116	45	i	i	PRON
admet-2626	116	46	>	>	X
admet-2626	116	47	1	1	NUM
admet-2626	116	48	m.	m.	NOUN
admet-2626	116	49	as	as	SCONJ
admet-2626	116	50	ions	ion	NOUN
admet-2626	116	51	are	be	AUX
admet-2626	116	52	added	add	VERB
admet-2626	116	53	to	to	ADP
admet-2626	116	54	pure	pure	ADJ
admet-2626	116	55	water	water	NOUN
admet-2626	116	56	,	,	PUNCT
admet-2626	116	57	some	some	PRON
admet-2626	116	58	of	of	ADP
admet-2626	116	59	the	the	DET
admet-2626	116	60	water	water	NOUN
admet-2626	116	61	molecules	molecule	NOUN
admet-2626	116	62	are	be	AUX
admet-2626	116	63	removed	remove	VERB
admet-2626	116	64	from	from	ADP
admet-2626	116	65	the	the	DET
admet-2626	116	66	initial	initial	ADJ
admet-2626	116	67	pure	pure	ADJ
admet-2626	116	68	water	water	NOUN
admet-2626	116	69	and	and	CCONJ
admet-2626	116	70	taken	take	VERB
admet-2626	116	71	up	up	ADP
admet-2626	116	72	by	by	ADP
admet-2626	116	73	the	the	DET
admet-2626	116	74	ions	ion	NOUN
admet-2626	116	75	as	as	ADP
admet-2626	116	76	part	part	NOUN
admet-2626	116	77	of	of	ADP
admet-2626	116	78	their	their	PRON
admet-2626	116	79	primary	primary	ADJ
admet-2626	116	80	solvation	solvation	NOUN
admet-2626	116	81	shells	shell	NOUN
admet-2626	116	82	.	.	PUNCT
admet-2626	117	1	for	for	ADP
admet-2626	117	2	example	example	NOUN
admet-2626	117	3	,	,	PUNCT
admet-2626	117	4	hydrogen	hydrogen	NOUN
admet-2626	117	5	ions	ion	NOUN
admet-2626	117	6	are	be	AUX
admet-2626	117	7	thought	think	VERB
admet-2626	117	8	to	to	PART
admet-2626	117	9	sequester	sequester	VERB
admet-2626	117	10	seven	seven	NUM
admet-2626	117	11	water	water	NOUN
admet-2626	117	12	molecules	molecule	NOUN
admet-2626	117	13	into	into	ADP
admet-2626	117	14	the	the	DET
admet-2626	117	15	solvation	solvation	NOUN
admet-2626	117	16	shell	shell	NOUN
admet-2626	117	17	,	,	PUNCT
admet-2626	117	18	but	but	CCONJ
admet-2626	117	19	chloride	chloride	NOUN
admet-2626	117	20	ions	ion	NOUN
admet-2626	117	21	only	only	ADV
admet-2626	117	22	hold	hold	VERB
admet-2626	117	23	one	one	NUM
admet-2626	117	24	water	water	NOUN
admet-2626	117	25	molecule	molecule	NOUN
admet-2626	117	26	as	as	ADP
admet-2626	117	27	such	such	ADJ
admet-2626	117	28	[	[	NOUN
admet-2626	117	29	14	14	NUM
admet-2626	117	30	]	]	PUNCT
admet-2626	117	31	.	.	PUNCT
admet-2626	118	1	more	more	ADJ
admet-2626	118	2	water	water	NOUN
admet-2626	118	3	is	be	AUX
admet-2626	118	4	sequestered	sequester	VERB
admet-2626	118	5	if	if	SCONJ
admet-2626	118	6	the	the	DET
admet-2626	118	7	ions	ion	NOUN
admet-2626	118	8	are	be	AUX
admet-2626	118	9	multiply	multiply	ADV
admet-2626	118	10	charged	charge	VERB
admet-2626	118	11	and	and	CCONJ
admet-2626	118	12	arise	arise	VERB
admet-2626	118	13	from	from	ADP
admet-2626	118	14	relatively	relatively	ADV
admet-2626	118	15	soluble	soluble	ADJ
admet-2626	118	16	electrolytes	electrolyte	NOUN
admet-2626	118	17	(	(	PUNCT
admet-2626	118	18	e.g.	e.g.	ADV
admet-2626	118	19	mellitic	mellitic	ADJ
admet-2626	118	20	acid	acid	NOUN
admet-2626	118	21	,	,	PUNCT
admet-2626	118	22	lysine	lysine	NOUN
admet-2626	118	23	,	,	PUNCT
admet-2626	118	24	etc	etc	X
admet-2626	118	25	.	.	X
admet-2626	118	26	)	)	PUNCT
admet-2626	118	27	.	.	PUNCT
admet-2626	119	1	so	so	ADV
admet-2626	119	2	,	,	PUNCT
admet-2626	119	3	the	the	DET
admet-2626	119	4	presence	presence	NOUN
admet-2626	119	5	of	of	ADP
admet-2626	119	6	charged	charge	VERB
admet-2626	119	7	species	species	NOUN
admet-2626	119	8	results	result	NOUN
admet-2626	119	9	in	in	ADP
admet-2626	119	10	less	less	ADV
admet-2626	119	11	free	free	ADJ
admet-2626	119	12	water	water	NOUN
admet-2626	119	13	to	to	PART
admet-2626	119	14	dissolve	dissolve	VERB
admet-2626	119	15	the	the	DET
admet-2626	119	16	neutral	neutral	ADJ
admet-2626	119	17	molecule	molecule	NOUN
admet-2626	119	18	,	,	PUNCT
admet-2626	119	19	because	because	SCONJ
admet-2626	119	20	some	some	PRON
admet-2626	119	21	of	of	ADP
admet-2626	119	22	the	the	DET
admet-2626	119	23	water	water	NOUN
admet-2626	119	24	is	be	AUX
admet-2626	119	25	removed	remove	VERB
admet-2626	119	26	from	from	ADP
admet-2626	119	27	the	the	DET
admet-2626	119	28	bulk	bulk	ADJ
admet-2626	119	29	solvent	solvent	NOUN
admet-2626	119	30	into	into	ADP
admet-2626	119	31	the	the	DET
admet-2626	119	32	solvation	solvation	NOUN
admet-2626	119	33	shells	shell	NOUN
admet-2626	119	34	of	of	ADP
admet-2626	119	35	the	the	DET
admet-2626	119	36	ions	ion	NOUN
admet-2626	119	37	.	.	PUNCT
admet-2626	120	1	in	in	ADP
admet-2626	120	2	terms	term	NOUN
admet-2626	120	3	of	of	ADP
admet-2626	120	4	the	the	DET
admet-2626	120	5	total	total	ADJ
admet-2626	120	6	volume	volume	NOUN
admet-2626	120	7	of	of	ADP
admet-2626	120	8	water	water	NOUN
admet-2626	120	9	,	,	PUNCT
admet-2626	120	10	the	the	DET
admet-2626	120	11	solubility	solubility	NOUN
admet-2626	120	12	of	of	ADP
admet-2626	120	13	uncharged	uncharged	ADJ
admet-2626	120	14	species	specie	NOUN
admet-2626	120	15	appears	appear	VERB
admet-2626	120	16	to	to	PART
admet-2626	120	17	be	be	AUX
admet-2626	120	18	reduced	reduce	VERB
admet-2626	120	19	in	in	ADP
admet-2626	120	20	the	the	DET
admet-2626	120	21	presence	presence	NOUN
admet-2626	120	22	of	of	ADP
admet-2626	120	23	a	a	DET
admet-2626	120	24	large	large	ADJ
admet-2626	120	25	concentration	concentration	NOUN
admet-2626	120	26	of	of	ADP
admet-2626	120	27	solvated	solvated	ADJ
admet-2626	120	28	ions	ion	NOUN
admet-2626	120	29	,	,	PUNCT
admet-2626	120	30	since	since	SCONJ
admet-2626	120	31	it	it	PRON
admet-2626	120	32	is	be	AUX
admet-2626	120	33	the	the	DET
admet-2626	120	34	free	free	ADJ
admet-2626	120	35	water	water	NOUN
admet-2626	120	36	volume	volume	NOUN
admet-2626	120	37	that	that	PRON
admet-2626	120	38	dictates	dictate	VERB
admet-2626	120	39	the	the	DET
admet-2626	120	40	solubility	solubility	NOUN
admet-2626	120	41	equilibrium	equilibrium	NOUN
admet-2626	120	42	.	.	PUNCT
admet-2626	121	1	the	the	DET
admet-2626	121	2	phenomenon	phenomenon	NOUN
admet-2626	121	3	is	be	AUX
admet-2626	121	4	termed	term	VERB
admet-2626	121	5	‘	'	PUNCT
admet-2626	121	6	salting	salt	VERB
admet-2626	121	7	out	out	ADP
admet-2626	121	8	’	'	PUNCT
admet-2626	122	1	[	[	X
admet-2626	122	2	15	15	NUM
admet-2626	122	3	]	]	X
admet-2626	122	4	(	(	PUNCT
admet-2626	122	5	and	and	CCONJ
admet-2626	122	6	references	reference	NOUN
admet-2626	122	7	therein	therein	ADV
admet-2626	122	8	)	)	PUNCT
admet-2626	122	9	.	.	PUNCT
admet-2626	123	1	in	in	ADP
admet-2626	123	2	our	our	PRON
admet-2626	123	3	recent	recent	ADJ
admet-2626	123	4	study	study	NOUN
admet-2626	123	5	of	of	ADP
admet-2626	123	6	the	the	DET
admet-2626	123	7	impact	impact	NOUN
admet-2626	123	8	of	of	ADP
admet-2626	123	9	salting	salt	VERB
admet-2626	123	10	-	-	PUNCT
admet-2626	123	11	out	out	NOUN
admet-2626	123	12	on	on	ADP
admet-2626	123	13	equilibria	equilibrium	NOUN
admet-2626	123	14	involving	involve	VERB
admet-2626	123	15	self	self	NOUN
admet-2626	123	16	-	-	PUNCT
admet-2626	123	17	association	association	NOUN
admet-2626	123	18	of	of	ADP
admet-2626	123	19	an	an	DET
admet-2626	123	20	ionizable	ionizable	ADJ
admet-2626	123	21	solute	solute	NOUN
admet-2626	123	22	[	[	X
admet-2626	123	23	15	15	NUM
admet-2626	123	24	]	]	X
admet-2626	123	25	,	,	PUNCT
admet-2626	123	26	a	a	DET
admet-2626	123	27	model	model	NOUN
admet-2626	123	28	to	to	PART
admet-2626	123	29	predict	predict	VERB
admet-2626	123	30	salting	salt	VERB
admet-2626	123	31	-	-	PUNCT
admet-2626	123	32	out	out	ADP
admet-2626	123	33	constants	constant	NOUN
admet-2626	123	34	was	be	AUX
admet-2626	123	35	introduced	introduce	VERB
admet-2626	123	36	,	,	PUNCT
admet-2626	123	37	as	as	SCONJ
admet-2626	123	38	further	far	ADV
admet-2626	123	39	described	describe	VERB
admet-2626	123	40	by	by	ADP
admet-2626	123	41	eq	eq	PROPN
admet-2626	123	42	.	.	PUNCT
admet-2626	123	43	a5	a5	VERB
admet-2626	123	44	in	in	ADP
admet-2626	123	45	appendix	appendix	ADJ
admet-2626	123	46	a.	a.	NOUN
admet-2626	123	47	in	in	ADP
admet-2626	123	48	the	the	DET
admet-2626	123	49	present	present	ADJ
admet-2626	123	50	study	study	NOUN
admet-2626	123	51	,	,	PUNCT
admet-2626	123	52	we	we	PRON
admet-2626	123	53	compared	compare	VERB
admet-2626	123	54	the	the	DET
admet-2626	123	55	predicted	predict	VERB
admet-2626	123	56	activity	activity	NOUN
admet-2626	123	57	coefficients	coefficient	NOUN
admet-2626	123	58	of	of	ADP
admet-2626	123	59	neutral	neutral	ADJ
admet-2626	123	60	molecules	molecule	NOUN
admet-2626	123	61	using	use	VERB
admet-2626	123	62	the	the	DET
admet-2626	123	63	srht	srht	NOUN
admet-2626	123	64	model	model	NOUN
admet-2626	123	65	(	(	PUNCT
admet-2626	123	66	eq	eq	NOUN
admet-2626	123	67	.	.	PROPN
admet-2626	123	68	a4	a4	PROPN
admet-2626	123	69	)	)	PUNCT
admet-2626	123	70	with	with	ADP
admet-2626	123	71	those	those	PRON
admet-2626	123	72	arising	arise	VERB
admet-2626	123	73	from	from	ADP
admet-2626	123	74	the	the	DET
admet-2626	123	75	salting	salting	NOUN
admet-2626	123	76	-	-	PUNCT
admet-2626	123	77	out	out	ADP
admet-2626	123	78	equation	equation	NOUN
admet-2626	123	79	(	(	PUNCT
admet-2626	123	80	eq	eq	NOUN
admet-2626	123	81	.	.	PUNCT
admet-2626	123	82	a5	a5	PROPN
admet-2626	123	83	)	)	PUNCT
admet-2626	123	84	.	.	PUNCT
admet-2626	124	1	in	in	ADP
admet-2626	124	2	all	all	DET
admet-2626	124	3	the	the	DET
admet-2626	124	4	cases	case	NOUN
admet-2626	124	5	we	we	PRON
admet-2626	124	6	considered	consider	VERB
admet-2626	124	7	,	,	PUNCT
admet-2626	124	8	the	the	DET
admet-2626	124	9	legacy	legacy	NOUN
admet-2626	124	10	srht	srht	NOUN
admet-2626	124	11	appears	appear	VERB
admet-2626	124	12	to	to	PART
admet-2626	124	13	underestimate	underestimate	VERB
admet-2626	124	14	the	the	DET
admet-2626	124	15	effect	effect	NOUN
admet-2626	124	16	of	of	ADP
admet-2626	124	17	ion	ion	NOUN
admet-2626	124	18	-	-	PUNCT
admet-2626	124	19	water	water	NOUN
admet-2626	124	20	interactions	interaction	NOUN
admet-2626	124	21	on	on	ADP
admet-2626	124	22	the	the	DET
admet-2626	124	23	activity	activity	NOUN
admet-2626	124	24	of	of	ADP
admet-2626	124	25	uncharged	uncharged	ADJ
admet-2626	124	26	species	specie	NOUN
admet-2626	124	27	,	,	PUNCT
admet-2626	124	28	in	in	ADP
admet-2626	124	29	comparison	comparison	NOUN
admet-2626	124	30	to	to	ADP
admet-2626	124	31	that	that	PRON
admet-2626	124	32	of	of	ADP
admet-2626	124	33	the	the	DET
admet-2626	124	34	salting	salting	NOUN
admet-2626	124	35	-	-	PUNCT
admet-2626	124	36	out	out	ADP
admet-2626	124	37	effect	effect	NOUN
admet-2626	124	38	.	.	PUNCT
admet-2626	125	1	in	in	ADP
admet-2626	125	2	the	the	DET
admet-2626	125	3	present	present	ADJ
admet-2626	125	4	commentary	commentary	NOUN
admet-2626	125	5	,	,	PUNCT
admet-2626	125	6	we	we	PRON
admet-2626	125	7	propose	propose	VERB
admet-2626	125	8	a	a	DET
admet-2626	125	9	modified	modify	VERB
admet-2626	125	10	srht	srht	NOUN
admet-2626	125	11	model	model	NOUN
admet-2626	125	12	,	,	PUNCT
admet-2626	125	13	which	which	PRON
admet-2626	125	14	incorporates	incorporate	VERB
admet-2626	125	15	predicted	predict	VERB
admet-2626	125	16	saltingout	saltingout	NOUN
admet-2626	125	17	constants	constant	NOUN
admet-2626	125	18	to	to	PART
admet-2626	125	19	estimate	estimate	VERB
admet-2626	125	20	the	the	DET
admet-2626	125	21	activity	activity	NOUN
admet-2626	125	22	coefficients	coefficient	NOUN
admet-2626	125	23	of	of	ADP
admet-2626	125	24	neutral	neutral	ADJ
admet-2626	125	25	molecules	molecule	NOUN
admet-2626	125	26	.	.	PUNCT
admet-2626	126	1	the	the	DET
admet-2626	126	2	modified	modify	VERB
admet-2626	126	3	srht	srht	NOUN
admet-2626	126	4	model	model	NOUN
admet-2626	126	5	is	be	AUX
admet-2626	126	6	a	a	DET
admet-2626	126	7	tentative	tentative	ADJ
admet-2626	126	8	proposal	proposal	NOUN
admet-2626	126	9	,	,	PUNCT
admet-2626	126	10	awaiting	await	VERB
admet-2626	126	11	more	more	ADV
admet-2626	126	12	direct	direct	ADJ
admet-2626	126	13	experimental	experimental	ADJ
admet-2626	126	14	confirmation	confirmation	NOUN
admet-2626	126	15	.	.	PUNCT
admet-2626	127	1	since	since	SCONJ
admet-2626	127	2	salting	salt	VERB
admet-2626	127	3	-	-	PUNCT
admet-2626	127	4	out	out	ADP
admet-2626	127	5	studies	study	NOUN
admet-2626	127	6	have	have	AUX
admet-2626	127	7	been	be	AUX
admet-2626	127	8	performed	perform	VERB
admet-2626	127	9	far	far	ADV
admet-2626	127	10	more	more	ADV
admet-2626	127	11	often	often	ADV
admet-2626	127	12	than	than	ADP
admet-2626	127	13	applications	application	NOUN
admet-2626	127	14	of	of	ADP
admet-2626	127	15	srht	srht	NOUN
admet-2626	127	16	and	and	CCONJ
admet-2626	127	17	since	since	SCONJ
admet-2626	127	18	there	there	PRON
admet-2626	127	19	are	be	VERB
admet-2626	127	20	many	many	ADJ
admet-2626	127	21	measurements	measurement	NOUN
admet-2626	127	22	of	of	ADP
admet-2626	127	23	the	the	DET
admet-2626	127	24	effect	effect	NOUN
admet-2626	127	25	of	of	ADP
admet-2626	127	26	salt	salt	NOUN
admet-2626	127	27	on	on	ADP
admet-2626	127	28	the	the	DET
admet-2626	127	29	solubility	solubility	NOUN
admet-2626	127	30	of	of	ADP
admet-2626	127	31	uncharged	uncharged	ADJ
admet-2626	127	32	species	specie	NOUN
admet-2626	127	33	,	,	PUNCT
admet-2626	127	34	our	our	PRON
admet-2626	127	35	approach	approach	NOUN
admet-2626	127	36	in	in	ADP
admet-2626	127	37	this	this	DET
admet-2626	127	38	commentary	commentary	NOUN
admet-2626	127	39	may	may	AUX
admet-2626	127	40	be	be	AUX
admet-2626	127	41	an	an	DET
admet-2626	127	42	opportunity	opportunity	NOUN
admet-2626	127	43	to	to	PART
admet-2626	127	44	improve	improve	VERB
admet-2626	127	45	the	the	DET
admet-2626	127	46	srht	srht	NOUN
admet-2626	127	47	model	model	NOUN
admet-2626	127	48	for	for	ADP
admet-2626	127	49	future	future	ADJ
admet-2626	127	50	applications	application	NOUN
admet-2626	127	51	involving	involve	VERB
admet-2626	127	52	druglike	druglike	ADJ
admet-2626	127	53	molecules	molecule	NOUN
admet-2626	127	54	.	.	PUNCT
admet-2626	128	1	example	example	NOUN
admet-2626	128	2	of	of	ADP
admet-2626	128	3	the	the	DET
admet-2626	128	4	‘	'	PUNCT
admet-2626	128	5	constant	constant	ADJ
admet-2626	128	6	ionic	ionic	ADJ
admet-2626	128	7	medium	medium	ADJ
admet-2626	128	8	’	'	PUNCT
admet-2626	128	9	activity	activity	NOUN
admet-2626	128	10	scale	scale	NOUN
admet-2626	128	11	treatment	treatment	NOUN
admet-2626	128	12	in	in	ADP
admet-2626	128	13	subsaturated	subsaturated	ADJ
admet-2626	128	14	solution	solution	NOUN
admet-2626	128	15	consider	consider	VERB
admet-2626	128	16	the	the	DET
admet-2626	128	17	case	case	NOUN
admet-2626	128	18	of	of	ADP
admet-2626	128	19	a	a	DET
admet-2626	128	20	monoprotic	monoprotic	ADJ
admet-2626	128	21	weak	weak	ADJ
admet-2626	128	22	acid	acid	NOUN
admet-2626	128	23	,	,	PUNCT
admet-2626	128	24	acetaminophen	acetaminophen	NOUN
admet-2626	128	25	,	,	PUNCT
admet-2626	128	26	whose	whose	DET
admet-2626	128	27	ionization	ionization	NOUN
admet-2626	128	28	constant	constant	ADJ
admet-2626	128	29	at	at	ADP
admet-2626	128	30	iref	iref	NOUN
admet-2626	128	31	=	=	PUNCT
admet-2626	128	32	0.15	0.15	NUM
admet-2626	128	33	m	m	NOUN
admet-2626	128	34	and	and	CCONJ
admet-2626	128	35	37	37	NUM
admet-2626	128	36	°	°	NOUN
admet-2626	128	37	c	c	NOUN
admet-2626	128	38	is	be	AUX
admet-2626	128	39	pka	pka	PROPN
admet-2626	128	40	ref	ref	NOUN
admet-2626	128	41	=	=	PROPN
admet-2626	128	42	9.41	9.41	NUM
admet-2626	128	43	.	.	PUNCT
admet-2626	129	1	when	when	SCONJ
admet-2626	129	2	20	20	NUM
admet-2626	129	3	mg	mg	NOUN
admet-2626	129	4	of	of	ADP
admet-2626	129	5	pure	pure	ADJ
admet-2626	129	6	acetaminophen	acetaminophen	NOUN
admet-2626	129	7	are	be	AUX
admet-2626	129	8	added	add	VERB
admet-2626	129	9	to	to	ADP
admet-2626	129	10	1.0	1.0	NUM
admet-2626	129	11	ml	ml	NOUN
admet-2626	129	12	of	of	ADP
admet-2626	129	13	distilled	distil	VERB
admet-2626	129	14	water	water	NOUN
admet-2626	129	15	,	,	PUNCT
admet-2626	129	16	the	the	DET
admet-2626	129	17	equilibrated	equilibrate	VERB
admet-2626	129	18	ph	ph	NOUN
admet-2626	129	19	=	=	SYM
admet-2626	129	20	5.29	5.29	NUM
admet-2626	129	21	and	and	CCONJ
admet-2626	129	22	ionic	ionic	ADJ
admet-2626	129	23	strength	strength	NOUN
admet-2626	129	24	i	i	NOUN
admet-2626	129	25	=	=	NOUN
admet-2626	129	26	5.7	5.7	NUM
admet-2626	129	27	μm	μm	NOUN
admet-2626	129	28	at	at	ADP
admet-2626	129	29	the	the	DET
admet-2626	129	30	132	132	NUM
admet-2626	129	31	mm	mm	NOUN
admet-2626	129	32	subsaturation	subsaturation	NOUN
admet-2626	129	33	concentration	concentration	NOUN
admet-2626	129	34	.	.	PUNCT
admet-2626	130	1	to	to	PART
admet-2626	130	2	perform	perform	VERB
admet-2626	130	3	mass	mass	ADJ
admet-2626	130	4	action	action	NOUN
admet-2626	130	5	calculations	calculation	NOUN
admet-2626	130	6	in	in	ADP
admet-2626	130	7	the	the	DET
admet-2626	130	8	near	near	ADV
admet-2626	130	9	-	-	PUNCT
admet-2626	130	10	zero	zero	NUM
admet-2626	130	11	ionic	ionic	ADJ
admet-2626	130	12	strength	strength	NOUN
admet-2626	130	13	,	,	PUNCT
admet-2626	130	14	the	the	DET
admet-2626	130	15	pka	pka	PROPN
admet-2626	130	16	ref	ref	NOUN
admet-2626	130	17	needs	need	VERB
admet-2626	130	18	to	to	PART
admet-2626	130	19	be	be	AUX
admet-2626	130	20	adjusted	adjust	VERB
admet-2626	130	21	for	for	ADP
admet-2626	130	22	the	the	DET
admet-2626	130	23	changes	change	NOUN
admet-2626	130	24	in	in	ADP
admet-2626	130	25	activities	activity	NOUN
admet-2626	130	26	between	between	ADP
admet-2626	130	27	the	the	DET
admet-2626	130	28	two	two	NUM
admet-2626	130	29	ionic	ionic	ADJ
admet-2626	130	30	strengths	strength	NOUN
admet-2626	130	31	(	(	PUNCT
admet-2626	130	32	5.7	5.7	NUM
admet-2626	130	33	μm	μm	NOUN
admet-2626	130	34	and	and	CCONJ
admet-2626	130	35	0.15	0.15	NUM
admet-2626	130	36	m	m	NOUN
admet-2626	130	37	)	)	PUNCT
admet-2626	130	38	.	.	PUNCT
admet-2626	131	1	the	the	DET
admet-2626	131	2	general	general	ADJ
admet-2626	131	3	eq	eq	PROPN
admet-2626	131	4	.	.	PROPN
admet-2626	131	5	a3	a3	PROPN
admet-2626	131	6	in	in	ADP
admet-2626	131	7	appendix	appendix	NOUN
admet-2626	131	8	a	a	DET
admet-2626	131	9	reduces	reduce	NOUN
admet-2626	131	10	to	to	ADP
admet-2626	131	11	eq	eq	NOUN
admet-2626	131	12	.	.	PUNCT
admet-2626	132	1	(	(	PUNCT
admet-2626	132	2	1	1	NUM
admet-2626	132	3	):	):	PUNCT
admet-2626	132	4	ka	ka	PROPN
admet-2626	133	1	i	i	PRON
admet-2626	133	2	(	(	PUNCT
admet-2626	133	3	fa	fa	INTJ
admet-2626	133	4	ifh	ifh	INTJ
admet-2626	133	5	i	i	PROPN
admet-2626	133	6	/	/	SYM
admet-2626	133	7	fha	fha	PROPN
admet-2626	133	8	i	i	PROPN
admet-2626	133	9	)	)	PUNCT
admet-2626	134	1	=	=	SYM
admet-2626	134	2	ka	ka	PROPN
admet-2626	134	3	ref	ref	PROPN
admet-2626	134	4	(	(	PUNCT
admet-2626	134	5	fa	fa	INTJ
admet-2626	134	6	reffh	reffh	PROPN
admet-2626	134	7	ref	ref	PROPN
admet-2626	134	8	/	/	SYM
admet-2626	134	9	fha	fha	PROPN
admet-2626	134	10	ref	ref	NOUN
admet-2626	134	11	)	)	PUNCT
admet-2626	134	12	(	(	PUNCT
admet-2626	134	13	1	1	X
admet-2626	134	14	)	)	PUNCT
admet-2626	134	15	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	134	16	a.	a.	NOUN
admet-2626	134	17	avdeef	avdeef	PROPN
admet-2626	134	18	admet	admet	PROPN
admet-2626	134	19	&	&	CCONJ
admet-2626	134	20	dmpk	dmpk	PROPN
admet-2626	134	21	13(1	13(1	NUM
admet-2626	134	22	)	)	PUNCT
admet-2626	134	23	(	(	PUNCT
admet-2626	134	24	2025	2025	NUM
admet-2626	134	25	)	)	PUNCT
admet-2626	134	26	2626	2626	NUM
admet-2626	134	27	6	6	NUM
admet-2626	134	28	where	where	SCONJ
admet-2626	134	29	ka	ka	PROPN
admet-2626	134	30	i	i	PRON
admet-2626	134	31	is	be	AUX
admet-2626	134	32	the	the	DET
admet-2626	134	33	ionization	ionization	NOUN
admet-2626	134	34	constant	constant	ADJ
admet-2626	134	35	at	at	ADP
admet-2626	134	36	ionic	ionic	ADJ
admet-2626	134	37	strength	strength	NOUN
admet-2626	134	38	,	,	PUNCT
admet-2626	134	39	i	i	PRON
admet-2626	134	40	;	;	PUNCT
admet-2626	134	41	fa	fa	PROPN
admet-2626	134	42	,	,	PUNCT
admet-2626	134	43	fh	fh	PROPN
admet-2626	134	44	,	,	PUNCT
admet-2626	134	45	and	and	CCONJ
admet-2626	134	46	fha	fha	PROPN
admet-2626	134	47	are	be	AUX
admet-2626	134	48	the	the	DET
admet-2626	134	49	activity	activity	NOUN
admet-2626	134	50	coefficients	coefficient	NOUN
admet-2626	134	51	of	of	ADP
admet-2626	134	52	a-	a-	NUM
admet-2626	134	53	,	,	PUNCT
admet-2626	134	54	h+	h+	PROPN
admet-2626	134	55	,	,	PUNCT
admet-2626	134	56	and	and	CCONJ
admet-2626	134	57	ha	ha	INTJ
admet-2626	134	58	.	.	PUNCT
admet-2626	135	1	in	in	ADP
admet-2626	135	2	the	the	DET
admet-2626	135	3	subsaturated	subsaturate	VERB
admet-2626	135	4	solution	solution	NOUN
admet-2626	135	5	,	,	PUNCT
admet-2626	135	6	the	the	DET
admet-2626	135	7	activity	activity	NOUN
admet-2626	135	8	coefficient	coefficient	NOUN
admet-2626	135	9	of	of	ADP
admet-2626	135	10	the	the	DET
admet-2626	135	11	neutral	neutral	ADJ
admet-2626	135	12	species	specie	NOUN
admet-2626	135	13	,	,	PUNCT
admet-2626	135	14	ha	ha	INTJ
admet-2626	135	15	,	,	PUNCT
admet-2626	135	16	is	be	AUX
admet-2626	135	17	expected	expect	VERB
admet-2626	135	18	to	to	PART
admet-2626	135	19	be	be	AUX
admet-2626	135	20	near	near	ADP
admet-2626	135	21	unit	unit	NOUN
admet-2626	135	22	value	value	NOUN
admet-2626	135	23	,	,	PUNCT
admet-2626	135	24	independent	independent	ADJ
admet-2626	135	25	of	of	ADP
admet-2626	135	26	ionic	ionic	ADJ
admet-2626	135	27	strength	strength	NOUN
admet-2626	135	28	.	.	PUNCT
admet-2626	136	1	the	the	DET
admet-2626	136	2	activity	activity	NOUN
admet-2626	136	3	coefficients	coefficient	NOUN
admet-2626	136	4	of	of	ADP
admet-2626	136	5	the	the	DET
admet-2626	136	6	charged	charge	VERB
admet-2626	136	7	species	specie	NOUN
admet-2626	136	8	may	may	AUX
admet-2626	136	9	be	be	AUX
admet-2626	136	10	calculated	calculate	VERB
admet-2626	136	11	using	use	VERB
admet-2626	136	12	eq	eq	ADP
admet-2626	136	13	.	.	PROPN
admet-2626	136	14	a4	a4	PROPN
admet-2626	136	15	(	(	PUNCT
admet-2626	136	16	srht	srht	NOUN
admet-2626	136	17	)	)	PUNCT
admet-2626	136	18	.	.	PUNCT
admet-2626	137	1	since	since	SCONJ
admet-2626	137	2	both	both	DET
admet-2626	137	3	ionic	ionic	ADJ
admet-2626	137	4	strengths	strength	NOUN
admet-2626	137	5	are	be	AUX
admet-2626	137	6	relatively	relatively	ADV
admet-2626	137	7	low	low	ADJ
admet-2626	137	8	,	,	PUNCT
admet-2626	137	9	the	the	DET
admet-2626	137	10	first	first	ADJ
admet-2626	137	11	term	term	NOUN
admet-2626	137	12	of	of	ADP
admet-2626	137	13	eq	eq	NOUN
admet-2626	137	14	.	.	PROPN
admet-2626	137	15	a4	a4	PROPN
admet-2626	137	16	(	(	PUNCT
admet-2626	137	17	debye	debye	ADJ
admet-2626	137	18	-	-	PUNCT
admet-2626	137	19	hückel	hückel	NOUN
admet-2626	137	20	term	term	NOUN
admet-2626	137	21	)	)	PUNCT
admet-2626	137	22	dominates	dominate	VERB
admet-2626	137	23	.	.	PUNCT
admet-2626	138	1	at	at	ADP
admet-2626	138	2	i	i	NOUN
admet-2626	138	3	=	=	NOUN
admet-2626	138	4	5.7	5.7	NUM
admet-2626	138	5	μm	μm	NOUN
admet-2626	138	6	,	,	PUNCT
admet-2626	138	7	the	the	DET
admet-2626	138	8	calculated	calculate	VERB
admet-2626	138	9	activity	activity	NOUN
admet-2626	138	10	coefficients	coefficient	NOUN
admet-2626	138	11	are	be	AUX
admet-2626	138	12	:	:	PUNCT
admet-2626	138	13	fa	fa	INTJ
admet-2626	139	1	i	i	NOUN
admet-2626	139	2	=	=	PROPN
admet-2626	140	1	fh	fh	PROPN
admet-2626	140	2	i	i	NOUN
admet-2626	140	3	=	=	PUNCT
admet-2626	140	4	0.997	0.997	NUM
admet-2626	140	5	,	,	PUNCT
admet-2626	140	6	fha	fha	PROPN
admet-2626	140	7	i	i	PROPN
admet-2626	140	8	≡	≡	PROPN
admet-2626	140	9	1	1	X
admet-2626	140	10	.	.	PUNCT
admet-2626	141	1	at	at	ADP
admet-2626	141	2	iref	iref	NOUN
admet-2626	141	3	=	=	PUNCT
admet-2626	141	4	0.15	0.15	NUM
admet-2626	141	5	m	m	PROPN
admet-2626	141	6	,	,	PUNCT
admet-2626	141	7	the	the	DET
admet-2626	141	8	corresponding	corresponding	ADJ
admet-2626	141	9	coefficients	coefficient	NOUN
admet-2626	141	10	change	change	VERB
admet-2626	141	11	to	to	ADP
admet-2626	141	12	fa	fa	PROPN
admet-2626	141	13	ref	ref	NOUN
admet-2626	141	14	=	=	NOUN
admet-2626	141	15	0.769	0.769	NUM
admet-2626	141	16	,	,	PUNCT
admet-2626	141	17	fh	fh	PROPN
admet-2626	141	18	ref	ref	NOUN
admet-2626	141	19	=	=	NOUN
admet-2626	141	20	0.828	0.828	NUM
admet-2626	141	21	,	,	PUNCT
admet-2626	141	22	fha	fha	PROPN
admet-2626	141	23	ref	ref	NOUN
admet-2626	141	24	≡	≡	PROPN
admet-2626	141	25	1	1	NUM
admet-2626	141	26	.	.	PUNCT
admet-2626	141	27	inserting	insert	VERB
admet-2626	141	28	these	these	DET
admet-2626	141	29	values	value	NOUN
admet-2626	141	30	into	into	ADP
admet-2626	141	31	eq	eq	NOUN
admet-2626	141	32	.	.	PROPN
admet-2626	141	33	1	1	NUM
admet-2626	141	34	produces	produce	VERB
admet-2626	141	35	eqs	eqs	X
admet-2626	141	36	(	(	PUNCT
admet-2626	141	37	2a	2a	NUM
admet-2626	141	38	)	)	PUNCT
admet-2626	141	39	ka	ka	PROPN
admet-2626	142	1	i	i	PRON
admet-2626	142	2	∙	∙	PROPN
admet-2626	142	3	(	(	PUNCT
admet-2626	142	4	0.9970.997)/1	0.9970.997)/1	NUM
admet-2626	142	5	=	=	SYM
admet-2626	142	6	ka	ka	PROPN
admet-2626	142	7	ref	ref	PROPN
admet-2626	142	8	(	(	PUNCT
admet-2626	142	9	0.7690.828)/1	0.7690.828)/1	PROPN
admet-2626	142	10	(	(	PUNCT
admet-2626	142	11	2a	2a	NUM
admet-2626	142	12	)	)	PUNCT
admet-2626	142	13	in	in	ADP
admet-2626	142	14	negative	negative	ADJ
admet-2626	142	15	log	log	NOUN
admet-2626	142	16	form	form	NOUN
admet-2626	142	17	,	,	PUNCT
admet-2626	142	18	eq	eq	NOUN
admet-2626	142	19	.	.	PROPN
admet-2626	142	20	(	(	PUNCT
admet-2626	142	21	2b	2b	NUM
admet-2626	142	22	)	)	PUNCT
admet-2626	143	1	pka	pka	PROPN
admet-2626	143	2	i	i	NOUN
admet-2626	143	3	=	=	PROPN
admet-2626	143	4	9.41	9.41	NUM
admet-2626	143	5	+	+	NUM
admet-2626	143	6	0.19	0.19	NUM
admet-2626	143	7	=	=	SYM
admet-2626	143	8	9.60	9.60	NUM
admet-2626	143	9	(	(	PUNCT
admet-2626	143	10	2b	2b	NUM
admet-2626	143	11	)	)	PUNCT
admet-2626	143	12	example	example	NOUN
admet-2626	143	13	of	of	ADP
admet-2626	143	14	the	the	DET
admet-2626	143	15	‘	'	PUNCT
admet-2626	143	16	constant	constant	ADJ
admet-2626	143	17	ionic	ionic	ADJ
admet-2626	143	18	medium	medium	ADJ
admet-2626	143	19	’	'	PUNCT
admet-2626	143	20	activity	activity	NOUN
admet-2626	143	21	scale	scale	NOUN
admet-2626	143	22	treatment	treatment	NOUN
admet-2626	143	23	in	in	ADP
admet-2626	143	24	saturated	saturate	VERB
admet-2626	143	25	solution	solution	NOUN
admet-2626	143	26	next	next	ADV
admet-2626	143	27	,	,	PUNCT
admet-2626	143	28	consider	consider	VERB
admet-2626	143	29	the	the	DET
admet-2626	143	30	case	case	NOUN
admet-2626	143	31	of	of	ADP
admet-2626	143	32	a	a	DET
admet-2626	143	33	saturated	saturate	VERB
admet-2626	143	34	solution	solution	NOUN
admet-2626	143	35	of	of	ADP
admet-2626	143	36	the	the	DET
admet-2626	143	37	drug	drug	NOUN
admet-2626	143	38	:	:	PUNCT
admet-2626	143	39	when	when	SCONJ
admet-2626	143	40	25	25	NUM
admet-2626	143	41	mg	mg	NOUN
admet-2626	143	42	of	of	ADP
admet-2626	143	43	pure	pure	ADJ
admet-2626	143	44	acetaminophen	acetaminophen	NOUN
admet-2626	143	45	are	be	AUX
admet-2626	143	46	added	add	VERB
admet-2626	143	47	to	to	ADP
admet-2626	143	48	1.0	1.0	NUM
admet-2626	143	49	ml	ml	NOUN
admet-2626	143	50	of	of	ADP
admet-2626	143	51	distilled	distil	VERB
admet-2626	143	52	water	water	NOUN
admet-2626	143	53	,	,	PUNCT
admet-2626	143	54	the	the	DET
admet-2626	143	55	calculated	calculated	ADJ
admet-2626	143	56	saturation	saturation	NOUN
admet-2626	143	57	ph	ph	VERB
admet-2626	143	58	5.28	5.28	NUM
admet-2626	143	59	at	at	ADP
admet-2626	143	60	the	the	DET
admet-2626	143	61	added	add	VERB
admet-2626	143	62	total	total	ADJ
admet-2626	143	63	concentration	concentration	NOUN
admet-2626	143	64	of	of	ADP
admet-2626	143	65	164	164	NUM
admet-2626	143	66	mm	mm	NOUN
admet-2626	143	67	,	,	PUNCT
admet-2626	143	68	with	with	ADP
admet-2626	143	69	i	i	PRON
admet-2626	143	70	=	=	NOUN
admet-2626	143	71	6.6	6.6	NUM
admet-2626	143	72	μm	μm	NOUN
admet-2626	143	73	.	.	PUNCT
admet-2626	144	1	the	the	DET
admet-2626	144	2	two	two	NUM
admet-2626	144	3	equilibrium	equilibrium	NOUN
admet-2626	144	4	equations	equation	NOUN
admet-2626	144	5	(	(	PUNCT
admet-2626	144	6	in	in	ADP
admet-2626	144	7	cumulative	cumulative	ADJ
admet-2626	144	8	form	form	NOUN
admet-2626	144	9	,	,	PUNCT
admet-2626	144	10	eq	eq	NOUN
admet-2626	144	11	.	.	PROPN
admet-2626	144	12	a2	a2	PROPN
admet-2626	144	13	)	)	PUNCT
admet-2626	144	14	are	be	AUX
admet-2626	144	15	a	a	DET
admet-2626	144	16	+	+	NOUN
admet-2626	144	17	h	h	NOUN
admet-2626	144	18			NOUN
admet-2626	145	1	ha	ha	INTJ
admet-2626	145	2	and	and	CCONJ
admet-2626	145	3	a	a	DET
admet-2626	145	4	+	+	NOUN
admet-2626	145	5	h	h	NOUN
admet-2626	145	6			NOUN
admet-2626	145	7	ha(s	ha(s	X
admet-2626	145	8	)	)	PUNCT
admet-2626	145	9	.	.	PUNCT
admet-2626	146	1	the	the	DET
admet-2626	146	2	cumulative	cumulative	ADJ
admet-2626	146	3	constant	constant	NOUN
admet-2626	146	4	for	for	ADP
admet-2626	146	5	the	the	DET
admet-2626	146	6	second	second	ADJ
admet-2626	146	7	equation	equation	NOUN
admet-2626	146	8	,	,	PUNCT
admet-2626	146	9	ha(s	ha(s	PROPN
admet-2626	146	10	)	)	PUNCT
admet-2626	146	11	ref	ref	NOUN
admet-2626	146	12	=	=	NOUN
admet-2626	146	13	pka	pka	PROPN
admet-2626	146	14	ref	ref	NOUN
admet-2626	146	15	+	+	CCONJ
admet-2626	146	16	ps0	ps0	ADJ
admet-2626	146	17	ref	ref	NOUN
admet-2626	146	18	=	=	NOUN
admet-2626	147	1	9.41	9.41	NUM
admet-2626	147	2	+0.87	+0.87	X
admet-2626	147	3	=	=	SYM
admet-2626	147	4	10.28	10.28	NUM
admet-2626	147	5	.	.	PUNCT
admet-2626	148	1	the	the	DET
admet-2626	148	2	activity	activity	NOUN
admet-2626	148	3	coefficient	coefficient	NOUN
admet-2626	148	4	of	of	ADP
admet-2626	148	5	the	the	DET
admet-2626	148	6	solid	solid	ADJ
admet-2626	148	7	species	specie	NOUN
admet-2626	148	8	,	,	PUNCT
admet-2626	148	9	fha(s	fha(s	PROPN
admet-2626	148	10	)	)	PUNCT
admet-2626	148	11	i	i	PROPN
admet-2626	148	12	and	and	CCONJ
admet-2626	148	13	fha(s	fha(s	PROPN
admet-2626	148	14	)	)	PUNCT
admet-2626	148	15	ref	ref	NOUN
admet-2626	148	16	are	be	AUX
admet-2626	148	17	generally	generally	ADV
admet-2626	148	18	defined	define	VERB
admet-2626	148	19	as	as	ADP
admet-2626	148	20	unit	unit	NOUN
admet-2626	148	21	value	value	NOUN
admet-2626	148	22	.	.	PUNCT
admet-2626	149	1	the	the	DET
admet-2626	149	2	salting	salting	NOUN
admet-2626	149	3	-	-	PUNCT
admet-2626	149	4	out	out	ADP
admet-2626	149	5	constant	constant	ADJ
admet-2626	149	6	of	of	ADP
admet-2626	149	7	acetaminophen	acetaminophen	NOUN
admet-2626	149	8	,	,	PUNCT
admet-2626	149	9	ksalt	ksalt	NOUN
admet-2626	149	10	=	=	SYM
admet-2626	149	11	0.117	0.117	NUM
admet-2626	149	12	m-1	m-1	NUM
admet-2626	149	13	,	,	PUNCT
admet-2626	149	14	is	be	AUX
admet-2626	149	15	used	use	VERB
admet-2626	149	16	to	to	PART
admet-2626	149	17	determine	determine	VERB
admet-2626	149	18	the	the	DET
admet-2626	149	19	activity	activity	NOUN
admet-2626	149	20	of	of	ADP
admet-2626	149	21	ha	ha	NOUN
admet-2626	149	22	:	:	PUNCT
admet-2626	149	23	log	log	VERB
admet-2626	150	1	fha	fha	PROPN
admet-2626	150	2	i	i	NOUN
admet-2626	150	3	=	=	NOUN
admet-2626	150	4	0.1176.610	0.1176.610	NOUN
admet-2626	150	5	-	-	SYM
admet-2626	150	6	6	6	NUM
admet-2626	150	7	=	=	SYM
admet-2626	150	8	7.7210	7.7210	NUM
admet-2626	150	9	-	-	SYM
admet-2626	150	10	7	7	NUM
admet-2626	150	11	or	or	CCONJ
admet-2626	150	12	fha	fha	PROPN
admet-2626	150	13	i	i	PROPN
admet-2626	150	14	=	=	PROPN
admet-2626	150	15	1.000002	1.000002	NUM
admet-2626	150	16	;	;	PUNCT
admet-2626	150	17	log	log	NOUN
admet-2626	150	18	fha	fha	PROPN
admet-2626	150	19	ref	ref	NOUN
admet-2626	150	20	=	=	PUNCT
admet-2626	151	1	0.1170.15	0.1170.15	NUM
admet-2626	151	2	=	=	PUNCT
admet-2626	151	3	0.0176	0.0176	NUM
admet-2626	151	4	or	or	CCONJ
admet-2626	151	5	fha	fha	PROPN
admet-2626	151	6	ref	ref	NOUN
admet-2626	151	7	=	=	PROPN
admet-2626	151	8	1.04124	1.04124	NUM
admet-2626	151	9	.	.	PUNCT
admet-2626	152	1	the	the	DET
admet-2626	152	2	activity	activity	NOUN
admet-2626	152	3	coefficients	coefficient	NOUN
admet-2626	152	4	of	of	ADP
admet-2626	152	5	the	the	DET
admet-2626	152	6	ions	ion	NOUN
admet-2626	152	7	are	be	AUX
admet-2626	152	8	practically	practically	ADV
admet-2626	152	9	unchanged	unchanged	ADJ
admet-2626	152	10	from	from	ADP
admet-2626	152	11	the	the	DET
admet-2626	152	12	prior	prior	ADJ
admet-2626	152	13	example	example	NOUN
admet-2626	152	14	:	:	PUNCT
admet-2626	152	15	fa	fa	PROPN
admet-2626	153	1	i	i	NOUN
admet-2626	153	2	=	=	PROPN
admet-2626	154	1	fh	fh	PROPN
admet-2626	154	2	i	i	NOUN
admet-2626	154	3	=	=	PROPN
admet-2626	154	4	0.997	0.997	NUM
admet-2626	154	5	,	,	PUNCT
admet-2626	154	6	fa	fa	INTJ
admet-2626	154	7	ref	ref	NOUN
admet-2626	154	8	=	=	NOUN
admet-2626	154	9	0.769	0.769	NUM
admet-2626	154	10	,	,	PUNCT
admet-2626	154	11	fh	fh	PROPN
admet-2626	154	12	ref	ref	NOUN
admet-2626	154	13	=	=	NOUN
admet-2626	154	14	0.828	0.828	NUM
admet-2626	154	15	.	.	PUNCT
admet-2626	155	1	the	the	DET
admet-2626	155	2	pka	pka	PROPN
admet-2626	155	3	equation	equation	NOUN
admet-2626	155	4	is	be	AUX
admet-2626	155	5	treated	treat	VERB
admet-2626	155	6	similarly	similarly	ADV
admet-2626	155	7	as	as	ADP
admet-2626	155	8	in	in	ADP
admet-2626	155	9	the	the	DET
admet-2626	155	10	prior	prior	ADJ
admet-2626	155	11	example	example	NOUN
admet-2626	155	12	:	:	PUNCT
admet-2626	155	13	pka	pka	PROPN
admet-2626	155	14	i	i	NOUN
admet-2626	155	15	=	=	NOUN
admet-2626	155	16	9.62	9.62	NUM
admet-2626	155	17	(	(	PUNCT
admet-2626	155	18	slightly	slightly	ADV
admet-2626	155	19	different	different	ADJ
admet-2626	155	20	from	from	ADP
admet-2626	155	21	9.60	9.60	NUM
admet-2626	155	22	due	due	ADP
admet-2626	155	23	to	to	ADP
admet-2626	155	24	the	the	DET
admet-2626	155	25	use	use	NOUN
admet-2626	155	26	of	of	ADP
admet-2626	155	27	salting	salt	VERB
admet-2626	155	28	-	-	PUNCT
admet-2626	155	29	out	out	ADP
admet-2626	155	30	constant	constant	ADJ
admet-2626	155	31	)	)	PUNCT
admet-2626	155	32	.	.	PUNCT
admet-2626	156	1	the	the	DET
admet-2626	156	2	solubility	solubility	NOUN
admet-2626	156	3	equation	equation	NOUN
admet-2626	156	4	in	in	ADP
admet-2626	156	5	cumulative	cumulative	ADJ
admet-2626	156	6	form	form	NOUN
admet-2626	156	7	(	(	PUNCT
admet-2626	156	8	cf	cf	NOUN
admet-2626	156	9	.	.	PUNCT
admet-2626	157	1	eq	eq	NOUN
admet-2626	157	2	.	.	PROPN
admet-2626	157	3	a2	a2	PROPN
admet-2626	157	4	)	)	PUNCT
admet-2626	157	5	at	at	ADP
admet-2626	157	6	the	the	DET
admet-2626	157	7	local	local	ADJ
admet-2626	157	8	ionic	ionic	ADJ
admet-2626	157	9	strength	strength	NOUN
admet-2626	157	10	is	be	AUX
admet-2626	157	11	determined	determine	VERB
admet-2626	157	12	(	(	PUNCT
admet-2626	157	13	eq	eq	NOUN
admet-2626	157	14	.	.	PROPN
admet-2626	157	15	a3	a3	PROPN
admet-2626	157	16	)	)	PUNCT
admet-2626	157	17	as	as	ADP
admet-2626	157	18	log	log	PROPN
admet-2626	157	19	ha(s	ha(s	PROPN
admet-2626	157	20	)	)	PUNCT
admet-2626	158	1	i	i	PRON
admet-2626	158	2	=	=	SYM
admet-2626	158	3	log	log	VERB
admet-2626	158	4	ha(s	ha(s	PROPN
admet-2626	158	5	)	)	PUNCT
admet-2626	158	6	ref	ref	NOUN
admet-2626	158	7	+	+	CCONJ
admet-2626	158	8	log	log	NOUN
admet-2626	158	9	(	(	PUNCT
admet-2626	158	10	fa	fa	INTJ
admet-2626	158	11	i	i	PROPN
admet-2626	158	12	/	/	SYM
admet-2626	158	13	fa	fa	PROPN
admet-2626	158	14	ref	ref	NOUN
admet-2626	158	15	)	)	PUNCT
admet-2626	159	1	+	+	CCONJ
admet-2626	159	2	log	log	NOUN
admet-2626	159	3	(	(	PUNCT
admet-2626	159	4	fh	fh	INTJ
admet-2626	159	5	i	i	PROPN
admet-2626	159	6	/	/	SYM
admet-2626	159	7	fh	fh	PROPN
admet-2626	159	8	ref	ref	PROPN
admet-2626	159	9	)	)	PUNCT
admet-2626	159	10	.	.	PUNCT
admet-2626	160	1	with	with	ADP
admet-2626	160	2	the	the	DET
admet-2626	160	3	above	above	ADJ
admet-2626	160	4	activity	activity	NOUN
admet-2626	160	5	coefficients	coefficient	NOUN
admet-2626	160	6	,	,	PUNCT
admet-2626	160	7	log	log	VERB
admet-2626	160	8	ha(s	ha(s	PROPN
admet-2626	160	9	)	)	PUNCT
admet-2626	160	10	i	i	NOUN
admet-2626	160	11	=	=	NOUN
admet-2626	161	1	10.28	10.28	NUM
admet-2626	161	2	+	+	CCONJ
admet-2626	161	3	log	log	NOUN
admet-2626	161	4	(	(	PUNCT
admet-2626	161	5	0.997/0.769	0.997/0.769	NOUN
admet-2626	161	6	)	)	PUNCT
admet-2626	162	1	+	+	NUM
admet-2626	162	2	log	log	NOUN
admet-2626	162	3	(	(	PUNCT
admet-2626	162	4	0.997/0.828	0.997/0.828	PROPN
admet-2626	162	5	)	)	PUNCT
admet-2626	162	6	=	=	PUNCT
admet-2626	162	7	10.47	10.47	NUM
admet-2626	162	8	.	.	PUNCT
admet-2626	163	1	from	from	ADP
admet-2626	163	2	this	this	PRON
admet-2626	163	3	,	,	PUNCT
admet-2626	163	4	ps0	ps0	VERB
admet-2626	163	5	i	i	NOUN
admet-2626	163	6	=	=	NOUN
admet-2626	163	7	10.47	10.47	NUM
admet-2626	163	8	9.62	9.62	NUM
admet-2626	163	9	=	=	SYM
admet-2626	163	10	0.85	0.85	NUM
admet-2626	163	11	(	(	PUNCT
admet-2626	163	12	140	140	NUM
admet-2626	163	13	mm	mm	NOUN
admet-2626	163	14	)	)	PUNCT
admet-2626	163	15	,	,	PUNCT
admet-2626	163	16	which	which	PRON
admet-2626	163	17	is	be	AUX
admet-2626	163	18	only	only	ADV
admet-2626	163	19	slightly	slightly	ADV
admet-2626	163	20	lower	low	ADJ
admet-2626	163	21	than	than	ADP
admet-2626	163	22	ps0	ps0	ADJ
admet-2626	163	23	ref	ref	NOUN
admet-2626	163	24	by	by	ADP
admet-2626	163	25	0.02	0.02	NUM
admet-2626	163	26	(=	(=	NOUN
admet-2626	163	27	-ksalt(i	-ksalt(i	ADJ
admet-2626	163	28	-	-	PUNCT
admet-2626	163	29	iref	iref	NOUN
admet-2626	163	30	)	)	PUNCT
admet-2626	163	31	)	)	PUNCT
admet-2626	163	32	.	.	PUNCT
admet-2626	164	1	example	example	NOUN
admet-2626	164	2	of	of	ADP
admet-2626	164	3	the	the	DET
admet-2626	164	4	‘	'	PUNCT
admet-2626	164	5	constant	constant	ADJ
admet-2626	164	6	ionic	ionic	ADJ
admet-2626	164	7	medium	medium	ADJ
admet-2626	164	8	’	'	PUNCT
admet-2626	164	9	activity	activity	NOUN
admet-2626	164	10	scale	scale	NOUN
admet-2626	164	11	treatment	treatment	NOUN
admet-2626	164	12	in	in	ADP
admet-2626	164	13	ph	ph	VERB
admet-2626	164	14	-	-	ADJ
admet-2626	164	15	adjusted	adjust	VERB
admet-2626	164	16	saturated	saturate	VERB
admet-2626	164	17	solution	solution	NOUN
admet-2626	164	18	as	as	ADP
admet-2626	164	19	a	a	DET
admet-2626	164	20	further	further	ADJ
admet-2626	164	21	example	example	NOUN
admet-2626	164	22	drawing	draw	VERB
admet-2626	164	23	on	on	ADP
admet-2626	164	24	analytic	analytic	ADJ
admet-2626	164	25	continuation	continuation	NOUN
admet-2626	164	26	of	of	ADP
admet-2626	164	27	the	the	DET
admet-2626	164	28	above	above	ADJ
admet-2626	164	29	case	case	NOUN
admet-2626	164	30	,	,	PUNCT
admet-2626	164	31	consider	consider	VERB
admet-2626	164	32	that	that	SCONJ
admet-2626	164	33	0.5	0.5	NUM
admet-2626	164	34	m	m	NOUN
admet-2626	164	35	hcl	hcl	PROPN
admet-2626	164	36	is	be	AUX
admet-2626	164	37	added	add	VERB
admet-2626	164	38	so	so	SCONJ
admet-2626	164	39	that	that	SCONJ
admet-2626	164	40	the	the	DET
admet-2626	164	41	ph	ph	NOUN
admet-2626	164	42	is	be	AUX
admet-2626	164	43	lowered	lower	VERB
admet-2626	164	44	to	to	ADP
admet-2626	164	45	0.05	0.05	NUM
admet-2626	164	46	(	(	PUNCT
admet-2626	164	47	pah	pah	PROPN
admet-2626	164	48	)	)	PUNCT
admet-2626	164	49	.	.	PUNCT
admet-2626	165	1	the	the	DET
admet-2626	165	2	activity	activity	NOUN
admet-2626	165	3	coefficients	coefficient	NOUN
admet-2626	165	4	of	of	ADP
admet-2626	165	5	the	the	DET
admet-2626	165	6	various	various	ADJ
admet-2626	165	7	species	specie	NOUN
admet-2626	165	8	need	need	VERB
admet-2626	165	9	to	to	PART
admet-2626	165	10	be	be	AUX
admet-2626	165	11	adjusted	adjust	VERB
admet-2626	165	12	accordingly	accordingly	ADV
admet-2626	165	13	.	.	PUNCT
admet-2626	166	1	so	so	ADV
admet-2626	166	2	,	,	PUNCT
admet-2626	166	3	at	at	ADP
admet-2626	166	4	the	the	DET
admet-2626	166	5	target	target	NOUN
admet-2626	166	6	(	(	PUNCT
admet-2626	166	7	local	local	ADJ
admet-2626	166	8	)	)	PUNCT
admet-2626	166	9	ph	ph	PROPN
admet-2626	166	10	,	,	PUNCT
admet-2626	166	11	the	the	DET
admet-2626	166	12	ionic	ionic	ADJ
admet-2626	166	13	strength	strength	NOUN
admet-2626	166	14	increases	increase	VERB
admet-2626	166	15	to	to	ADP
admet-2626	166	16	i	i	PROPN
admet-2626	166	17	=	=	NOUN
admet-2626	166	18	0.5	0.5	NUM
admet-2626	166	19	m.	m.	NOUN
admet-2626	166	20	the	the	DET
admet-2626	166	21	second	second	ADJ
admet-2626	166	22	two	two	NUM
admet-2626	166	23	terms	term	NOUN
admet-2626	166	24	in	in	ADP
admet-2626	166	25	eq	eq	ADP
admet-2626	166	26	.	.	NOUN
admet-2626	166	27	a4	a4	NOUN
admet-2626	166	28	take	take	VERB
admet-2626	166	29	on	on	ADP
admet-2626	166	30	more	more	ADJ
admet-2626	166	31	significance	significance	NOUN
admet-2626	166	32	in	in	ADP
admet-2626	166	33	the	the	DET
admet-2626	166	34	high	high	ADJ
admet-2626	166	35	ionic	ionic	ADJ
admet-2626	166	36	strength	strength	NOUN
admet-2626	166	37	case	case	NOUN
admet-2626	166	38	.	.	PUNCT
admet-2626	167	1	using	use	VERB
admet-2626	167	2	the	the	DET
admet-2626	167	3	approach	approach	NOUN
admet-2626	167	4	presented	present	VERB
admet-2626	167	5	above	above	ADV
admet-2626	167	6	,	,	PUNCT
admet-2626	167	7	fa	fa	INTJ
admet-2626	167	8	i	i	NOUN
admet-2626	167	9	=	=	NOUN
admet-2626	167	10	0.743	0.743	NUM
admet-2626	167	11	,	,	PUNCT
admet-2626	167	12	fa	fa	INTJ
admet-2626	167	13	ref	ref	NOUN
admet-2626	167	14	=	=	NOUN
admet-2626	167	15	0.822	0.822	NUM
admet-2626	167	16	,	,	PUNCT
admet-2626	167	17	fh	fh	INTJ
admet-2626	167	18	i	i	NOUN
admet-2626	167	19	=	=	PROPN
admet-2626	167	20	0.888	0.888	NUM
admet-2626	167	21	,	,	PUNCT
admet-2626	167	22	fh	fh	PROPN
admet-2626	167	23	ref	ref	NOUN
admet-2626	167	24	=	=	SYM
admet-2626	167	25	0.885	0.885	NUM
admet-2626	167	26	,	,	PUNCT
admet-2626	167	27	and	and	CCONJ
admet-2626	167	28	fha	fha	PROPN
admet-2626	167	29	i	i	NOUN
admet-2626	167	30	=	=	NOUN
admet-2626	167	31	1.144	1.144	NUM
admet-2626	167	32	,	,	PUNCT
admet-2626	167	33	fha	fha	PROPN
admet-2626	167	34	ref	ref	NOUN
admet-2626	167	35	=	=	NOUN
admet-2626	167	36	1.041	1.041	NUM
admet-2626	167	37	.	.	PUNCT
admet-2626	168	1	these	these	DET
admet-2626	168	2	values	value	NOUN
admet-2626	168	3	substituted	substitute	VERB
admet-2626	168	4	into	into	ADP
admet-2626	168	5	eq	eq	NOUN
admet-2626	168	6	.	.	PROPN
admet-2626	168	7	1	1	NUM
admet-2626	168	8	indicate	indicate	VERB
admet-2626	168	9	that	that	SCONJ
admet-2626	168	10	the	the	DET
admet-2626	168	11	pka	pka	PROPN
admet-2626	168	12	value	value	NOUN
admet-2626	168	13	at	at	ADP
admet-2626	168	14	i	i	X
admet-2626	168	15	=	=	NOUN
admet-2626	168	16	0.50	0.50	NUM
admet-2626	168	17	m	m	NOUN
admet-2626	168	18	becomes	become	VERB
admet-2626	168	19	9.33	9.33	NUM
admet-2626	168	20	;	;	PUNCT
admet-2626	168	21	that	that	PRON
admet-2626	168	22	is	be	AUX
admet-2626	168	23	,	,	PUNCT
admet-2626	168	24	higher	high	ADJ
admet-2626	168	25	salt	salt	NOUN
admet-2626	168	26	concentration	concentration	NOUN
admet-2626	168	27	makes	make	VERB
admet-2626	168	28	the	the	DET
admet-2626	168	29	weak	weak	ADJ
admet-2626	168	30	acid	acid	NOUN
admet-2626	168	31	slightly	slightly	ADV
admet-2626	168	32	stronger	strong	ADJ
admet-2626	168	33	.	.	PUNCT
admet-2626	169	1	the	the	DET
admet-2626	169	2	ps0	ps0	ADJ
admet-2626	169	3	i	i	PRON
admet-2626	169	4	at	at	ADP
admet-2626	169	5	ph	ph	PROPN
admet-2626	169	6	0.05	0.05	NUM
admet-2626	169	7	(	(	PUNCT
admet-2626	169	8	eq	eq	NOUN
admet-2626	169	9	.	.	PUNCT
admet-2626	169	10	(	(	PUNCT
admet-2626	169	11	3	3	NUM
admet-2626	169	12	)	)	PUNCT
admet-2626	169	13	)	)	PUNCT
admet-2626	169	14	now	now	ADV
admet-2626	169	15	increases	increase	VERB
admet-2626	169	16	from	from	ADP
admet-2626	169	17	the	the	DET
admet-2626	169	18	value	value	NOUN
admet-2626	169	19	of	of	ADP
admet-2626	169	20	0.87	0.87	NUM
admet-2626	169	21	at	at	ADP
admet-2626	169	22	phw	phw	NOUN
admet-2626	169	23	5.28	5.28	NUM
admet-2626	169	24	to	to	PART
admet-2626	169	25	ps0	ps0	VERB
admet-2626	169	26	i	i	PRON
admet-2626	169	27	=	=	PUNCT
admet-2626	169	28	ps0	ps0	ADJ
admet-2626	169	29	ref	ref	NOUN
admet-2626	170	1	+	+	CCONJ
admet-2626	170	2	(	(	PUNCT
admet-2626	170	3	pka	pka	PROPN
admet-2626	170	4	ref	ref	NOUN
admet-2626	170	5	pka	pka	PROPN
admet-2626	170	6	i	i	PROPN
admet-2626	170	7	)	)	PUNCT
admet-2626	171	1	+	+	CCONJ
admet-2626	171	2	log	log	NOUN
admet-2626	171	3	(	(	PUNCT
admet-2626	171	4	fa	fa	INTJ
admet-2626	171	5	i	i	PROPN
admet-2626	171	6	/	/	SYM
admet-2626	171	7	fa	fa	PROPN
admet-2626	171	8	ref	ref	NOUN
admet-2626	171	9	)	)	PUNCT
admet-2626	172	1	+	+	CCONJ
admet-2626	172	2	log	log	NOUN
admet-2626	172	3	(	(	PUNCT
admet-2626	172	4	fh	fh	INTJ
admet-2626	172	5	i	i	PROPN
admet-2626	172	6	/	/	SYM
admet-2626	172	7	fh	fh	PROPN
admet-2626	172	8	ref	ref	NOUN
admet-2626	172	9	)	)	PUNCT
admet-2626	172	10	=	=	PUNCT
admet-2626	173	1	=	=	PUNCT
admet-2626	174	1	0.87	0.87	NUM
admet-2626	174	2	+	+	CCONJ
admet-2626	174	3	(	(	PUNCT
admet-2626	174	4	9.41	9.41	NUM
admet-2626	174	5	9.33	9.33	NUM
admet-2626	174	6	)	)	PUNCT
admet-2626	175	1	+	+	CCONJ
admet-2626	175	2	log	log	NOUN
admet-2626	175	3	(	(	PUNCT
admet-2626	175	4	0.743/0.822	0.743/0.822	NOUN
admet-2626	175	5	)	)	PUNCT
admet-2626	176	1	+	+	CCONJ
admet-2626	176	2	log	log	NOUN
admet-2626	176	3	(	(	PUNCT
admet-2626	176	4	0.888/0.885	0.888/0.885	PROPN
admet-2626	176	5	)	)	PUNCT
admet-2626	176	6	=	=	SYM
admet-2626	176	7	0.91	0.91	NUM
admet-2626	176	8	(	(	PUNCT
admet-2626	176	9	3	3	NUM
admet-2626	176	10	)	)	PUNCT
admet-2626	176	11	thus	thus	ADV
admet-2626	176	12	,	,	PUNCT
admet-2626	176	13	at	at	ADP
admet-2626	176	14	ph	ph	PROPN
admet-2626	176	15	0.05	0.05	NUM
admet-2626	176	16	,	,	PUNCT
admet-2626	176	17	the	the	DET
admet-2626	176	18	solubility	solubility	NOUN
admet-2626	176	19	(	(	PUNCT
admet-2626	176	20	solid	solid	ADJ
admet-2626	176	21	curve	curve	NOUN
admet-2626	176	22	in	in	ADP
admet-2626	176	23	fig	fig	NOUN
admet-2626	176	24	.	.	PUNCT
admet-2626	177	1	1c	1c	NOUN
admet-2626	177	2	)	)	PUNCT
admet-2626	177	3	crosses	cross	VERB
admet-2626	177	4	the	the	DET
admet-2626	177	5	hh	hh	PROPN
admet-2626	177	6	curve	curve	NOUN
admet-2626	177	7	(	(	PUNCT
admet-2626	177	8	140	140	NUM
admet-2626	177	9	mm	mm	NOUN
admet-2626	177	10	:	:	PUNCT
admet-2626	177	11	dashed	dash	VERB
admet-2626	177	12	curve	curve	NOUN
admet-2626	177	13	in	in	ADP
admet-2626	177	14	fig	fig	NOUN
admet-2626	177	15	.	.	PUNCT
admet-2626	178	1	1c	1c	NOUN
admet-2626	178	2	)	)	PUNCT
admet-2626	178	3	as	as	ADP
admet-2626	178	4	the	the	DET
admet-2626	178	5	solubility	solubility	NOUN
admet-2626	178	6	in	in	ADP
admet-2626	178	7	the	the	DET
admet-2626	178	8	higher	high	ADJ
admet-2626	178	9	ionic	ionic	ADJ
admet-2626	178	10	strength	strength	NOUN
admet-2626	178	11	suspension	suspension	NOUN
admet-2626	178	12	drops	drop	VERB
admet-2626	178	13	to	to	ADP
admet-2626	178	14	122	122	NUM
admet-2626	178	15	mm	mm	NOUN
admet-2626	178	16	.	.	PUNCT
admet-2626	179	1	in	in	ADP
admet-2626	179	2	this	this	DET
admet-2626	179	3	manner	manner	NOUN
admet-2626	179	4	,	,	PUNCT
admet-2626	179	5	at	at	ADP
admet-2626	179	6	every	every	DET
admet-2626	179	7	ph	ph	ADJ
admet-2626	179	8	point	point	NOUN
admet-2626	179	9	,	,	PUNCT
admet-2626	179	10	a	a	DET
admet-2626	179	11	different	different	ADJ
admet-2626	179	12	set	set	NOUN
admet-2626	179	13	of	of	ADP
admet-2626	179	14	pka	pka	PROPN
admet-2626	179	15	i	i	PROPN
admet-2626	179	16	and	and	CCONJ
admet-2626	179	17	ps0	ps0	VERB
admet-2626	179	18	i	i	PRON
admet-2626	179	19	need	need	VERB
admet-2626	179	20	to	to	PART
admet-2626	179	21	be	be	AUX
admet-2626	179	22	determined	determine	VERB
admet-2626	179	23	,	,	PUNCT
admet-2626	179	24	from	from	ADP
admet-2626	179	25	which	which	PRON
admet-2626	179	26	the	the	DET
admet-2626	179	27	local	local	ADJ
admet-2626	179	28	concentrations	concentration	NOUN
admet-2626	179	29	of	of	ADP
admet-2626	179	30	reactants	reactant	NOUN
admet-2626	179	31	and	and	CCONJ
admet-2626	179	32	product	product	NOUN
admet-2626	179	33	species	specie	NOUN
admet-2626	179	34	are	be	AUX
admet-2626	179	35	then	then	ADV
admet-2626	179	36	calculated	calculate	VERB
admet-2626	179	37	.	.	PUNCT
admet-2626	180	1	admet	admet	PROPN
admet-2626	180	2	&	&	CCONJ
admet-2626	180	3	dmpk	dmpk	PROPN
admet-2626	180	4	13(1	13(1	NUM
admet-2626	180	5	)	)	PUNCT
admet-2626	180	6	(	(	PUNCT
admet-2626	180	7	2025	2025	NUM
admet-2626	180	8	)	)	PUNCT
admet-2626	180	9	2626	2626	NUM
admet-2626	180	10	transforming	transform	VERB
admet-2626	180	11	drug	drug	NOUN
admet-2626	180	12	solubility	solubility	NOUN
admet-2626	180	13	measurement	measurement	NOUN
admet-2626	180	14	doi	doi	PROPN
admet-2626	180	15	:	:	PUNCT
admet-2626	180	16	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	180	17	7	7	NUM
admet-2626	180	18	results	result	NOUN
admet-2626	180	19	and	and	CCONJ
admet-2626	180	20	discussion	discussion	NOUN
admet-2626	180	21	ionization	ionization	NOUN
admet-2626	180	22	constants	constant	NOUN
admet-2626	180	23	table	table	NOUN
admet-2626	180	24	1	1	NUM
admet-2626	180	25	lists	list	NOUN
admet-2626	180	26	pairs	pair	NOUN
admet-2626	180	27	of	of	ADP
admet-2626	180	28	pka	pka	PROPN
admet-2626	180	29	values	value	NOUN
admet-2626	180	30	(	(	PUNCT
admet-2626	180	31	pka	pka	PROPN
admet-2626	180	32	ref	ref	NOUN
admet-2626	180	33	and	and	CCONJ
admet-2626	180	34	pka	pka	PROPN
admet-2626	180	35	i	i	PROPN
admet-2626	180	36	)	)	PUNCT
admet-2626	180	37	of	of	ADP
admet-2626	180	38	the	the	DET
admet-2626	180	39	32	32	NUM
admet-2626	180	40	weakly	weakly	ADJ
admet-2626	180	41	ionizable	ionizable	ADJ
admet-2626	180	42	molecules	molecule	NOUN
admet-2626	180	43	considered	consider	VERB
admet-2626	180	44	in	in	ADP
admet-2626	180	45	the	the	DET
admet-2626	180	46	study	study	NOUN
admet-2626	180	47	.	.	PUNCT
admet-2626	181	1	the	the	DET
admet-2626	181	2	listed	list	VERB
admet-2626	181	3	temperature	temperature	NOUN
admet-2626	181	4	is	be	AUX
admet-2626	181	5	that	that	PRON
admet-2626	181	6	of	of	ADP
admet-2626	181	7	the	the	DET
admet-2626	181	8	corresponding	corresponding	ADJ
admet-2626	181	9	solubility	solubility	NOUN
admet-2626	181	10	study	study	NOUN
admet-2626	181	11	.	.	PUNCT
admet-2626	182	1	in	in	ADP
admet-2626	182	2	the	the	DET
admet-2626	182	3	solubility	solubility	NOUN
admet-2626	182	4	measurements	measurement	NOUN
admet-2626	182	5	in	in	ADP
admet-2626	182	6	pure	pure	ADJ
admet-2626	182	7	water	water	NOUN
admet-2626	182	8	,	,	PUNCT
admet-2626	182	9	the	the	DET
admet-2626	182	10	benchmark	benchmark	NOUN
admet-2626	182	11	reference	reference	NOUN
admet-2626	182	12	ionic	ionic	ADJ
admet-2626	182	13	strength	strength	NOUN
admet-2626	182	14	was	be	AUX
admet-2626	182	15	selected	select	VERB
admet-2626	182	16	as	as	ADP
admet-2626	182	17	iref	iref	NOUN
admet-2626	182	18	=	=	PUNCT
admet-2626	182	19	0.15	0.15	NUM
admet-2626	182	20	m.	m.	NOUN
admet-2626	182	21	the	the	DET
admet-2626	182	22	local	local	ADJ
admet-2626	182	23	values	value	NOUN
admet-2626	182	24	of	of	ADP
admet-2626	182	25	ionic	ionic	ADJ
admet-2626	182	26	strength	strength	NOUN
admet-2626	182	27	,	,	PUNCT
admet-2626	182	28	iw	iw	PROPN
admet-2626	182	29	(	(	PUNCT
admet-2626	182	30	calculated	calculate	VERB
admet-2626	182	31	at	at	ADP
admet-2626	182	32	phw	phw	NOUN
admet-2626	182	33	)	)	PUNCT
admet-2626	182	34	,	,	PUNCT
admet-2626	182	35	are	be	AUX
admet-2626	182	36	listed	list	VERB
admet-2626	182	37	.	.	PUNCT
admet-2626	183	1	values	value	NOUN
admet-2626	183	2	of	of	ADP
admet-2626	183	3	pka	pka	PROPN
admet-2626	183	4	ref	ref	NOUN
admet-2626	183	5	are	be	AUX
admet-2626	183	6	taken	take	VERB
admet-2626	183	7	from	from	ADP
admet-2626	183	8	published	publish	VERB
admet-2626	183	9	sources	source	NOUN
admet-2626	183	10	[	[	X
admet-2626	183	11	28	28	NUM
admet-2626	183	12	-	-	SYM
admet-2626	183	13	34	34	NUM
admet-2626	183	14	]	]	PUNCT
admet-2626	183	15	;	;	PUNCT
admet-2626	183	16	the	the	DET
admet-2626	183	17	corresponding	correspond	VERB
admet-2626	183	18	pka	pka	PROPN
admet-2626	183	19	i	i	PRON
admet-2626	183	20	(	(	PUNCT
admet-2626	183	21	at	at	ADP
admet-2626	183	22	phw	phw	NOUN
admet-2626	183	23	)	)	PUNCT
admet-2626	183	24	were	be	AUX
admet-2626	183	25	calculated	calculate	VERB
admet-2626	183	26	using	use	VERB
admet-2626	184	1	pdisol	pdisol	ADJ
admet-2626	184	2	-	-	PUNCT
admet-2626	184	3	x	x	SYM
admet-2626	184	4	(	(	PUNCT
admet-2626	184	5	cf	cf	NOUN
admet-2626	184	6	.	.	PUNCT
admet-2626	184	7	eqs	eqs	PROPN
admet-2626	184	8	.	.	PUNCT
admet-2626	185	1	(	(	PUNCT
admet-2626	185	2	1	1	X
admet-2626	185	3	)	)	PUNCT
admet-2626	185	4	and	and	CCONJ
admet-2626	185	5	(	(	PUNCT
admet-2626	185	6	2	2	NUM
admet-2626	185	7	)	)	PUNCT
admet-2626	185	8	.	.	PUNCT
admet-2626	186	1	solubility	solubility	NOUN
admet-2626	186	2	data	datum	NOUN
admet-2626	186	3	and	and	CCONJ
admet-2626	186	4	constants	constant	NOUN
admet-2626	186	5	tables	table	VERB
admet-2626	186	6	2	2	NUM
admet-2626	186	7	-	-	SYM
admet-2626	186	8	4	4	NUM
admet-2626	186	9	summarize	summarize	VERB
admet-2626	186	10	the	the	DET
admet-2626	186	11	details	detail	NOUN
admet-2626	186	12	of	of	ADP
admet-2626	186	13	the	the	DET
admet-2626	186	14	analyses	analysis	NOUN
admet-2626	186	15	of	of	ADP
admet-2626	186	16	the	the	DET
admet-2626	186	17	published	publish	VERB
admet-2626	186	18	weak	weak	ADJ
admet-2626	186	19	acid	acid	NOUN
admet-2626	186	20	,	,	PUNCT
admet-2626	186	21	base	base	NOUN
admet-2626	186	22	,	,	PUNCT
admet-2626	186	23	and	and	CCONJ
admet-2626	186	24	ampholyte	ampholyte	ADJ
admet-2626	186	25	solubility	solubility	NOUN
admet-2626	186	26	measurements	measurement	NOUN
admet-2626	186	27	in	in	ADP
admet-2626	186	28	pure	pure	ADJ
admet-2626	186	29	water	water	NOUN
admet-2626	186	30	.	.	PUNCT
admet-2626	187	1	the	the	DET
admet-2626	187	2	literature	literature	NOUN
admet-2626	187	3	values	value	NOUN
admet-2626	187	4	of	of	ADP
admet-2626	187	5	log	log	PROPN
admet-2626	187	6	sw	sw	PROPN
admet-2626	187	7	,	,	PUNCT
admet-2626	187	8	along	along	ADP
admet-2626	187	9	with	with	ADP
admet-2626	187	10	the	the	DET
admet-2626	187	11	corresponding	corresponding	ADJ
admet-2626	187	12	pka	pka	PROPN
admet-2626	187	13	values	value	NOUN
admet-2626	187	14	(	(	PUNCT
admet-2626	187	15	table	table	NOUN
admet-2626	187	16	1	1	NUM
admet-2626	187	17	)	)	PUNCT
admet-2626	187	18	,	,	PUNCT
admet-2626	187	19	were	be	AUX
admet-2626	187	20	the	the	DET
admet-2626	187	21	starting	starting	NOUN
admet-2626	187	22	points	point	NOUN
admet-2626	187	23	in	in	ADP
admet-2626	187	24	the	the	DET
admet-2626	187	25	determination	determination	NOUN
admet-2626	187	26	of	of	ADP
admet-2626	187	27	phw	phw	NOUN
admet-2626	187	28	and	and	CCONJ
admet-2626	187	29	log	log	NOUN
admet-2626	187	30	s0	s0	PROPN
admet-2626	187	31	ref	ref	NOUN
admet-2626	187	32	.	.	PUNCT
admet-2626	188	1	activity	activity	NOUN
admet-2626	188	2	corrections	correction	NOUN
admet-2626	188	3	(	(	PUNCT
admet-2626	188	4	eqs	eqs	X
admet-2626	188	5	.	.	PUNCT
admet-2626	188	6	(	(	PUNCT
admet-2626	188	7	1	1	X
admet-2626	188	8	)	)	PUNCT
admet-2626	188	9	to	to	ADP
admet-2626	188	10	(	(	PUNCT
admet-2626	188	11	3	3	NUM
admet-2626	188	12	)	)	PUNCT
admet-2626	188	13	,	,	PUNCT
admet-2626	188	14	based	base	VERB
admet-2626	188	15	on	on	ADP
admet-2626	188	16	the	the	DET
admet-2626	188	17	general	general	ADJ
admet-2626	188	18	eq	eq	PROPN
admet-2626	188	19	.	.	PROPN
admet-2626	188	20	a3	a3	PROPN
admet-2626	188	21	in	in	ADP
admet-2626	188	22	appendix	appendix	NOUN
admet-2626	188	23	a	a	PRON
admet-2626	188	24	)	)	PUNCT
admet-2626	188	25	were	be	AUX
admet-2626	188	26	applied	apply	VERB
admet-2626	188	27	to	to	ADP
admet-2626	188	28	ionic	ionic	ADJ
admet-2626	188	29	species	specie	NOUN
admet-2626	188	30	.	.	PUNCT
admet-2626	189	1	in	in	ADP
admet-2626	189	2	addition	addition	NOUN
admet-2626	189	3	,	,	PUNCT
admet-2626	189	4	ksalt	ksalt	NOUN
admet-2626	189	5	salting	salting	NOUN
admet-2626	189	6	-	-	PUNCT
admet-2626	189	7	out	out	ADP
admet-2626	189	8	constants	constant	NOUN
admet-2626	189	9	(	(	PUNCT
admet-2626	189	10	eq	eq	NOUN
admet-2626	189	11	.	.	PUNCT
admet-2626	189	12	(	(	PUNCT
admet-2626	189	13	3	3	X
admet-2626	189	14	)	)	PUNCT
admet-2626	189	15	based	base	VERB
admet-2626	189	16	on	on	ADP
admet-2626	189	17	eq	eq	PROPN
admet-2626	189	18	.	.	PUNCT
admet-2626	189	19	(	(	PUNCT
admet-2626	189	20	a5	a5	PROPN
admet-2626	189	21	)	)	PUNCT
admet-2626	189	22	)	)	PUNCT
admet-2626	189	23	were	be	AUX
admet-2626	189	24	used	use	VERB
admet-2626	189	25	to	to	PART
admet-2626	189	26	adjust	adjust	VERB
admet-2626	189	27	the	the	DET
admet-2626	189	28	activities	activity	NOUN
admet-2626	189	29	of	of	ADP
admet-2626	189	30	uncharged	uncharged	ADJ
admet-2626	189	31	species	specie	NOUN
admet-2626	189	32	.	.	PUNCT
admet-2626	190	1	in	in	ADP
admet-2626	190	2	most	most	ADJ
admet-2626	190	3	cases	case	NOUN
admet-2626	190	4	in	in	ADP
admet-2626	190	5	the	the	DET
admet-2626	190	6	tables	table	NOUN
admet-2626	190	7	,	,	PUNCT
admet-2626	190	8	the	the	DET
admet-2626	190	9	iw	iw	PROPN
admet-2626	190	10	value	value	NOUN
admet-2626	190	11	at	at	ADP
admet-2626	190	12	phw	phw	NOUN
admet-2626	190	13	is	be	AUX
admet-2626	190	14	near	near	ADP
admet-2626	190	15	zero	zero	NUM
admet-2626	190	16	,	,	PUNCT
admet-2626	190	17	particularly	particularly	ADV
admet-2626	190	18	in	in	ADP
admet-2626	190	19	the	the	DET
admet-2626	190	20	cases	case	NOUN
admet-2626	190	21	of	of	ADP
admet-2626	190	22	weak	weak	ADJ
admet-2626	190	23	bases	basis	NOUN
admet-2626	190	24	,	,	PUNCT
admet-2626	190	25	but	but	CCONJ
admet-2626	190	26	the	the	DET
admet-2626	190	27	values	value	NOUN
admet-2626	190	28	increase	increase	VERB
admet-2626	190	29	significantly	significantly	ADV
admet-2626	190	30	with	with	ADP
admet-2626	190	31	the	the	DET
admet-2626	190	32	benzene	benzene	ADJ
admet-2626	190	33	carboxylic	carboxylic	ADJ
admet-2626	190	34	acid	acid	NOUN
admet-2626	190	35	series	series	NOUN
admet-2626	190	36	,	,	PUNCT
admet-2626	190	37	reaching	reach	VERB
admet-2626	190	38	a	a	DET
admet-2626	190	39	high	high	ADJ
admet-2626	190	40	value	value	NOUN
admet-2626	190	41	of	of	ADP
admet-2626	190	42	0.49	0.49	NUM
admet-2626	190	43	m	m	NOUN
admet-2626	190	44	for	for	ADP
admet-2626	190	45	mellitic	mellitic	ADJ
admet-2626	190	46	acid	acid	NOUN
admet-2626	190	47	(	(	PUNCT
admet-2626	190	48	2	2	NUM
admet-2626	190	49	-	-	ADJ
admet-2626	190	50	fold	fold	ADJ
admet-2626	190	51	excess	excess	ADJ
admet-2626	190	52	added	add	VERB
admet-2626	190	53	solid	solid	NOUN
admet-2626	190	54	)	)	PUNCT
admet-2626	190	55	or	or	CCONJ
admet-2626	190	56	0.38	0.38	NUM
admet-2626	190	57	m	m	NOUN
admet-2626	190	58	for	for	ADP
admet-2626	190	59	mellitic	mellitic	ADJ
admet-2626	190	60	acid	acid	NOUN
admet-2626	190	61	(	(	PUNCT
admet-2626	190	62	10	10	NUM
admet-2626	190	63	-	-	ADJ
admet-2626	190	64	fold	fold	ADJ
admet-2626	190	65	excess	excess	NOUN
admet-2626	190	66	)	)	PUNCT
admet-2626	190	67	.	.	PUNCT
admet-2626	191	1	higher	high	ADJ
admet-2626	191	2	yet	yet	ADV
admet-2626	191	3	,	,	PUNCT
admet-2626	191	4	lysine	lysine	NOUN
admet-2626	191	5	at	at	ADP
admet-2626	191	6	phw	phw	NOUN
admet-2626	191	7	indicates	indicate	VERB
admet-2626	191	8	iw	iw	PROPN
admet-2626	191	9	=	=	PUNCT
admet-2626	191	10	0.61	0.61	NUM
admet-2626	191	11	m	m	NOUN
admet-2626	191	12	(	(	PUNCT
admet-2626	191	13	1.1	1.1	NUM
admet-2626	191	14	-	-	ADJ
admet-2626	191	15	fold	fold	ADJ
admet-2626	191	16	excess	excess	NOUN
admet-2626	191	17	)	)	PUNCT
admet-2626	191	18	or	or	CCONJ
admet-2626	191	19	iw	iw	INTJ
admet-2626	191	20	=	=	NOUN
admet-2626	191	21	0.70	0.70	NUM
admet-2626	191	22	m	m	NOUN
admet-2626	191	23	(	(	PUNCT
admet-2626	191	24	2	2	NUM
admet-2626	191	25	-	-	ADJ
admet-2626	191	26	fold	fold	ADJ
admet-2626	191	27	excess	excess	NOUN
admet-2626	191	28	)	)	PUNCT
admet-2626	191	29	.	.	PUNCT
admet-2626	192	1	table	table	NOUN
admet-2626	192	2	1	1	NUM
admet-2626	192	3	.	.	PUNCT
admet-2626	193	1	pka	pka	PROPN
admet-2626	193	2	of	of	ADP
admet-2626	193	3	acids	acid	NOUN
admet-2626	193	4	,	,	PUNCT
admet-2626	193	5	bases	basis	NOUN
admet-2626	193	6	,	,	PUNCT
admet-2626	193	7	and	and	CCONJ
admet-2626	193	8	ampholytes	ampholyte	NOUN
admet-2626	193	9	at	at	ADP
admet-2626	193	10	ionic	ionic	ADJ
admet-2626	193	11	strength	strength	NOUN
admet-2626	193	12	iref	iref	NOUN
admet-2626	193	13	=	=	PUNCT
admet-2626	193	14	0.15	0.15	NUM
admet-2626	193	15	m	m	NOUN
admet-2626	193	16	and	and	CCONJ
admet-2626	193	17	iw	iw	VERB
admet-2626	193	18	in	in	ADP
admet-2626	193	19	saturated	saturate	VERB
admet-2626	193	20	water	water	NOUN
admet-2626	193	21	solutions	solution	NOUN
admet-2626	193	22	at	at	ADP
admet-2626	193	23	phw	phw	NOUN
admet-2626	193	24	a	a	DET
admet-2626	193	25	substance	substance	NOUN
admet-2626	193	26	typeb	typeb	NOUN
admet-2626	193	27	t	t	PROPN
admet-2626	193	28	/	/	PUNCT
admet-2626	193	29	oc	oc	VERB
admet-2626	193	30	iw	iw	X
admet-2626	193	31	/	/	SYM
admet-2626	193	32	mmc	mmc	PROPN
admet-2626	193	33	pka1	pka1	PROPN
admet-2626	193	34	ref	ref	NOUN
admet-2626	193	35	pka1	pka1	PROPN
admet-2626	194	1	i	i	PRON
admet-2626	194	2	pka2	pka2	PROPN
admet-2626	194	3	ref	ref	VERB
admet-2626	194	4	pka2	pka2	PROPN
admet-2626	195	1	i	i	PRON
admet-2626	195	2	pka3	pka3	NOUN
admet-2626	195	3	ref	ref	VERB
admet-2626	195	4	pka3	pka3	NOUN
admet-2626	195	5	i	i	PRON
admet-2626	195	6	pka4	pka4	VERB
admet-2626	195	7	ref	ref	NOUN
admet-2626	195	8	pka4	pka4	NOUN
admet-2626	196	1	i	i	PRON
admet-2626	196	2	pka5	pka5	PROPN
admet-2626	196	3	ref	ref	NOUN
admet-2626	196	4	pka5	pka5	PROPN
admet-2626	197	1	i	i	PRON
admet-2626	197	2	pka6	pka6	PROPN
admet-2626	197	3	ref	ref	NOUN
admet-2626	197	4	pka6	pka6	PROPN
admet-2626	198	1	i	i	PRON
admet-2626	198	2	acetaminophen	acetaminophen	VERB
admet-2626	198	3	a	a	DET
admet-2626	198	4	37	37	NUM
admet-2626	198	5	0.010	0.010	NUM
admet-2626	198	6	9.41	9.41	NUM
admet-2626	198	7	9.62	9.62	NUM
admet-2626	198	8	crocetin	crocetin	NOUN
admet-2626	198	9	a	a	DET
admet-2626	198	10	23	23	NUM
admet-2626	198	11	0.004	0.004	NUM
admet-2626	198	12	4.47	4.47	NUM
admet-2626	198	13	4.71	4.71	NUM
admet-2626	198	14	5.00	5.00	NUM
admet-2626	198	15	5.35	5.35	NUM
admet-2626	198	16	glibenclamide	glibenclamide	ADP
admet-2626	198	17	a	a	DET
admet-2626	198	18	37	37	NUM
admet-2626	198	19	0.017	0.017	NUM
admet-2626	198	20	5.18	5.18	NUM
admet-2626	198	21	5.40	5.40	NUM
admet-2626	198	22	indomethacin	indomethacin	VERB
admet-2626	198	23	a	a	DET
admet-2626	198	24	37	37	NUM
admet-2626	198	25	0.046	0.046	NUM
admet-2626	198	26	4.02	4.02	NUM
admet-2626	198	27	4.24	4.24	NUM
admet-2626	198	28	isotretinoin	isotretinoin	PROPN
admet-2626	198	29	a	a	DET
admet-2626	198	30	25	25	NUM
admet-2626	198	31	0.011	0.011	NUM
admet-2626	198	32	4.52	4.52	NUM
admet-2626	198	33	4.76	4.76	NUM
admet-2626	198	34	naproxen	naproxen	NOUN
admet-2626	198	35	a	a	DET
admet-2626	198	36	37	37	NUM
admet-2626	198	37	0.112	0.112	NUM
admet-2626	198	38	4.19	4.19	NUM
admet-2626	198	39	4.40	4.40	NUM
admet-2626	198	40	phenytoin	phenytoin	NOUN
admet-2626	198	41	a	a	DET
admet-2626	198	42	37	37	NUM
admet-2626	198	43	0.005	0.005	NUM
admet-2626	198	44	8.14	8.14	NUM
admet-2626	198	45	8.36	8.36	NUM
admet-2626	198	46	quercetin	quercetin	NOUN
admet-2626	198	47	a	a	DET
admet-2626	198	48	23	23	NUM
admet-2626	198	49	0.004	0.004	NUM
admet-2626	198	50	7.12	7.12	NUM
admet-2626	198	51	7.31	7.31	NUM
admet-2626	198	52	8.43	8.43	NUM
admet-2626	198	53	8.80	8.80	NUM
admet-2626	198	54	9.67	9.67	NUM
admet-2626	198	55	#	#	SYM
admet-2626	198	56	#	#	SYM
admet-2626	198	57	#	#	SYM
admet-2626	198	58	#	#	NOUN
admet-2626	198	59	10.63	10.63	NUM
admet-2626	198	60	#	#	SYM
admet-2626	198	61	#	#	SYM
admet-2626	198	62	#	#	SYM
admet-2626	198	63	#	#	NOUN
admet-2626	198	64	benzoic	benzoic	NOUN
admet-2626	198	65	acid	acid	NOUN
admet-2626	198	66	a	a	DET
admet-2626	198	67	25	25	NUM
admet-2626	198	68	1.4	1.4	NUM
admet-2626	198	69	3.99	3.99	NUM
admet-2626	198	70	4.17	4.17	NUM
admet-2626	198	71	phthalic	phthalic	ADJ
admet-2626	198	72	acid	acid	NOUN
admet-2626	198	73	,	,	PUNCT
admet-2626	198	74	2a	2a	NUM
admet-2626	198	75	25	25	NUM
admet-2626	198	76	7.6	7.6	NUM
admet-2626	198	77	2.71	2.71	NUM
admet-2626	198	78	2.85	2.85	NUM
admet-2626	198	79	4.90	4.90	NUM
admet-2626	198	80	5.14	5.14	NUM
admet-2626	198	81	trimellitic	trimellitic	ADJ
admet-2626	198	82	acid	acid	NOUN
admet-2626	198	83	a	a	DET
admet-2626	198	84	25	25	NUM
admet-2626	198	85	19	19	NUM
admet-2626	198	86	2.34	2.34	NUM
admet-2626	198	87	2.43	2.43	NUM
admet-2626	198	88	3.71	3.71	NUM
admet-2626	198	89	3.89	3.89	NUM
admet-2626	198	90	5.10	5.10	NUM
admet-2626	198	91	5.39	5.39	NUM
admet-2626	198	92	hemimellitic	hemimellitic	ADJ
admet-2626	198	93	acid	acid	NOUN
admet-2626	198	94	a	a	DET
admet-2626	198	95	25	25	NUM
admet-2626	198	96	23	23	NUM
admet-2626	198	97	2.60	2.60	NUM
admet-2626	198	98	2.69	2.69	NUM
admet-2626	198	99	3.78	3.78	NUM
admet-2626	198	100	3.95	3.95	NUM
admet-2626	198	101	5.45	5.45	NUM
admet-2626	198	102	5.71	5.71	NUM
admet-2626	198	103	pyromellitic	pyromellitic	ADJ
admet-2626	198	104	acid	acid	NOUN
admet-2626	198	105	a	a	DET
admet-2626	198	106	25	25	NUM
admet-2626	198	107	20	20	NUM
admet-2626	198	108	1.86	1.86	NUM
admet-2626	198	109	1.94	1.94	NUM
admet-2626	198	110	2.74	2.74	NUM
admet-2626	198	111	2.90	2.90	NUM
admet-2626	198	112	4.28	4.28	NUM
admet-2626	198	113	4.54	4.54	NUM
admet-2626	198	114	5.33	5.33	NUM
admet-2626	198	115	5.69	5.69	NUM
admet-2626	198	116	mellophanic	mellophanic	ADJ
admet-2626	198	117	acid	acid	NOUN
admet-2626	198	118	a	a	DET
admet-2626	198	119	25	25	NUM
admet-2626	198	120	102	102	NUM
admet-2626	198	121	2.00	2.00	NUM
admet-2626	198	122	2.01	2.01	NUM
admet-2626	198	123	3.11	3.11	NUM
admet-2626	198	124	3.15	3.15	NUM
admet-2626	198	125	4.51	4.51	NUM
admet-2626	198	126	4.57	4.57	NUM
admet-2626	198	127	5.91	5.91	NUM
admet-2626	198	128	5.99	5.99	NUM
admet-2626	198	129	benzenepentacarboxylic	benzenepentacarboxylic	NOUN
admet-2626	198	130	acid	acid	NOUN
admet-2626	198	131	a	a	DET
admet-2626	198	132	25	25	NUM
admet-2626	198	133	128	128	NUM
admet-2626	198	134	1.74	1.74	NUM
admet-2626	198	135	1.75	1.75	NUM
admet-2626	198	136	2.60	2.60	NUM
admet-2626	198	137	2.61	2.61	NUM
admet-2626	198	138	3.76	3.76	NUM
admet-2626	198	139	3.78	3.78	NUM
admet-2626	198	140	4.97	4.97	NUM
admet-2626	198	141	5.00	5.00	NUM
admet-2626	198	142	6.10	6.10	NUM
admet-2626	198	143	6.14	6.14	NUM
admet-2626	198	144	mellitic	mellitic	ADJ
admet-2626	198	145	acidd	acidd	NOUN
admet-2626	198	146	a	a	DET
admet-2626	198	147	25	25	NUM
admet-2626	198	148	381	381	NUM
admet-2626	198	149	1.10	1.10	NUM
admet-2626	198	150	1.09	1.09	NUM
admet-2626	198	151	1.69	1.69	NUM
admet-2626	198	152	1.63	1.63	NUM
admet-2626	198	153	2.75	2.75	NUM
admet-2626	198	154	2.64	2.64	NUM
admet-2626	198	155	4.00	4.00	NUM
admet-2626	198	156	3.85	3.85	NUM
admet-2626	198	157	5.05	5.05	NUM
admet-2626	198	158	4.83	4.83	NUM
admet-2626	198	159	6.04	6.04	NUM
admet-2626	198	160	5.77	5.77	NUM
admet-2626	198	161	mellitic	mellitic	ADJ
admet-2626	198	162	acide	acide	NOUN
admet-2626	198	163	a	a	DET
admet-2626	198	164	25	25	NUM
admet-2626	198	165	486	486	NUM
admet-2626	198	166	1.10	1.10	NUM
admet-2626	198	167	1.09	1.09	NUM
admet-2626	198	168	1.69	1.69	NUM
admet-2626	198	169	1.62	1.62	NUM
admet-2626	198	170	2.75	2.75	NUM
admet-2626	198	171	2.62	2.62	NUM
admet-2626	198	172	4.00	4.00	NUM
admet-2626	198	173	3.80	3.80	NUM
admet-2626	198	174	5.05	5.05	NUM
admet-2626	198	175	4.77	4.77	NUM
admet-2626	198	176	6.04	6.04	NUM
admet-2626	198	177	5.69	5.69	NUM
admet-2626	198	178	atenolol	atenolol	PROPN
admet-2626	198	179	b	b	PROPN
admet-2626	198	180	37	37	NUM
admet-2626	198	181	1.7	1.7	NUM
admet-2626	198	182	9.19	9.19	NUM
admet-2626	198	183	9.14	9.14	NUM
admet-2626	198	184	bedaquiline	bedaquiline	NOUN
admet-2626	198	185	b	b	NOUN
admet-2626	198	186	23	23	NUM
admet-2626	198	187	0.002	0.002	NUM
admet-2626	198	188	8.77	8.77	NUM
admet-2626	198	189	8.68	8.68	NUM
admet-2626	198	190	brigatinib	brigatinib	NOUN
admet-2626	198	191	b	b	PROPN
admet-2626	198	192	23	23	NUM
admet-2626	198	193	0.123	0.123	NUM
admet-2626	198	194	1.73	1.73	NUM
admet-2626	198	195	1.27	1.27	NUM
admet-2626	198	196	3.65	3.65	NUM
admet-2626	198	197	3.35	3.35	NUM
admet-2626	198	198	4.72	4.72	NUM
admet-2626	198	199	4.57	4.57	NUM
admet-2626	198	200	8.04	8.04	NUM
admet-2626	198	201	7.95	7.95	NUM
admet-2626	198	202	carvedilol	carvedilol	NOUN
admet-2626	198	203	b	b	NOUN
admet-2626	198	204	37	37	NUM
admet-2626	198	205	0.009	0.009	NUM
admet-2626	198	206	7.78	7.78	NUM
admet-2626	198	207	7.72	7.72	NUM
admet-2626	198	208	emtricitibine	emtricitibine	NOUN
admet-2626	198	209	b	b	PROPN
admet-2626	198	210	25	25	NUM
admet-2626	198	211	0.001	0.001	NUM
admet-2626	198	212	2.67	2.67	NUM
admet-2626	198	213	2.63	2.63	NUM
admet-2626	198	214	imatinib	imatinib	NOUN
admet-2626	198	215	b	b	NUM
admet-2626	198	216	23	23	NUM
admet-2626	198	217	0.004	0.004	NUM
admet-2626	198	218	1.71	1.71	NUM
admet-2626	198	219	1.19	1.19	NUM
admet-2626	198	220	3.10	3.10	NUM
admet-2626	198	221	2.76	2.76	NUM
admet-2626	198	222	3.88	3.88	NUM
admet-2626	198	223	3.71	3.71	NUM
admet-2626	198	224	8.03	8.03	NUM
admet-2626	198	225	7.96	7.96	NUM
admet-2626	198	226	imiquimod	imiquimod	PROPN
admet-2626	198	227	b	b	PROPN
admet-2626	198	228	25	25	NUM
admet-2626	198	229	0.001	0.001	NUM
admet-2626	198	230	3.55	3.55	NUM
admet-2626	198	231	3.33	3.33	NUM
admet-2626	198	232	6.54	6.54	NUM
admet-2626	198	233	6.48	6.48	NUM
admet-2626	198	234	ketoconazole	ketoconazole	NOUN
admet-2626	198	235	b	b	PROPN
admet-2626	198	236	37	37	NUM
admet-2626	198	237	0.001	0.001	NUM
admet-2626	198	238	3.32	3.32	NUM
admet-2626	198	239	3.16	3.16	NUM
admet-2626	198	240	6.17	6.17	NUM
admet-2626	198	241	6.09	6.09	NUM
admet-2626	198	242	lamotrigine	lamotrigine	NOUN
admet-2626	198	243	b	b	PROPN
admet-2626	198	244	37	37	NUM
admet-2626	198	245	0.002	0.002	NUM
admet-2626	198	246	5.24	5.24	NUM
admet-2626	198	247	5.19	5.19	NUM
admet-2626	198	248	lumefanatrine	lumefanatrine	NOUN
admet-2626	198	249	b	b	NOUN
admet-2626	198	250	23	23	NUM
admet-2626	198	251	0.004	0.004	NUM
admet-2626	198	252	9.35	9.35	NUM
admet-2626	198	253	9.25	9.25	NUM
admet-2626	198	254	celecoxib	celecoxib	NOUN
admet-2626	198	255	x	x	PROPN
admet-2626	198	256	37	37	NUM
admet-2626	198	257	0.0002	0.0002	NUM
admet-2626	198	258	2.11	2.11	NUM
admet-2626	198	259	2.05	2.05	NUM
admet-2626	198	260	9.37	9.37	NUM
admet-2626	198	261	9.59	9.59	NUM
admet-2626	198	262	enrofloxacin	enrofloxacin	PROPN
admet-2626	198	263	x	x	PUNCT
admet-2626	198	264	37	37	NUM
admet-2626	198	265	0.086	0.086	NUM
admet-2626	198	266	6.17	6.17	NUM
admet-2626	198	267	6.11	6.11	NUM
admet-2626	198	268	7.70	7.70	NUM
admet-2626	198	269	7.91	7.91	NUM
admet-2626	198	270	lysine	lysine	NOUN
admet-2626	198	271	,	,	PUNCT
admet-2626	198	272	l	l	NOUN
admet-2626	198	273	-	-	NOUN
admet-2626	198	274	f	f	X
admet-2626	198	275	x	x	SYM
admet-2626	198	276	27	27	NUM
admet-2626	198	277	695	695	NUM
admet-2626	198	278	2.20	2.20	NUM
admet-2626	198	279	2.36	2.36	NUM
admet-2626	198	280	9.12	9.12	NUM
admet-2626	198	281	9.24	9.24	NUM
admet-2626	198	282	10.64	10.64	NUM
admet-2626	198	283	#	#	SYM
admet-2626	198	284	#	#	SYM
admet-2626	198	285	#	#	SYM
admet-2626	198	286	#	#	NOUN
admet-2626	198	287	lysine	lysine	NOUN
admet-2626	198	288	,	,	PUNCT
admet-2626	198	289	l	l	NOUN
admet-2626	198	290	-	-	NOUN
admet-2626	198	291	g	g	NOUN
admet-2626	198	292	x	x	SYM
admet-2626	198	293	27	27	NUM
admet-2626	198	294	612	612	NUM
admet-2626	198	295	2.20	2.20	NUM
admet-2626	198	296	2.34	2.34	NUM
admet-2626	198	297	9.12	9.12	NUM
admet-2626	198	298	9.22	9.22	NUM
admet-2626	198	299	10.64	10.64	NUM
admet-2626	198	300	#	#	SYM
admet-2626	198	301	#	#	SYM
admet-2626	198	302	#	#	SYM
admet-2626	198	303	#	#	NOUN
admet-2626	198	304	mycophenolate	mycophenolate	NOUN
admet-2626	198	305	mofetil	mofetil	NOUN
admet-2626	198	306	x	x	X
admet-2626	198	307	37	37	NUM
admet-2626	198	308	0.038	0.038	NUM
admet-2626	198	309	5.64	5.64	NUM
admet-2626	198	310	5.56	5.56	NUM
admet-2626	198	311	8.26	8.26	NUM
admet-2626	198	312	8.50	8.50	NUM
admet-2626	198	313	piroxicam	piroxicam	NOUN
admet-2626	198	314	x	x	PUNCT
admet-2626	198	315	37	37	NUM
admet-2626	198	316	0.019	0.019	NUM
admet-2626	198	317	1.84	1.84	NUM
admet-2626	198	318	1.80	1.80	NUM
admet-2626	198	319	5.13	5.13	NUM
admet-2626	198	320	5.33	5.33	NUM
admet-2626	198	321	sulfamethoxazole	sulfamethoxazole	NOUN
admet-2626	198	322	x	x	PUNCT
admet-2626	198	323	37	37	NUM
admet-2626	198	324	0.024	0.024	NUM
admet-2626	198	325	1.97	1.97	NUM
admet-2626	198	326	1.92	1.92	NUM
admet-2626	198	327	5.65	5.65	NUM
admet-2626	198	328	5.86	5.86	NUM
admet-2626	198	329	apka	apka	NOUN
admet-2626	198	330	ref	ref	NOUN
admet-2626	198	331	refer	refer	VERB
admet-2626	198	332	to	to	ADP
admet-2626	198	333	published	publish	VERB
admet-2626	198	334	values	value	NOUN
admet-2626	198	335	,	,	PUNCT
admet-2626	198	336	harmonized	harmonize	VERB
admet-2626	198	337	to	to	PART
admet-2626	198	338	iref	iref	VERB
admet-2626	198	339	=	=	PUNCT
admet-2626	198	340	0.15	0.15	NUM
admet-2626	198	341	m	m	NOUN
admet-2626	198	342	;	;	PUNCT
admet-2626	199	1	pka	pka	PROPN
admet-2626	199	2	i	i	PRON
admet-2626	199	3	are	be	AUX
admet-2626	199	4	values	value	NOUN
admet-2626	199	5	transformed	transform	VERB
admet-2626	199	6	to	to	ADP
admet-2626	199	7	iw	iw	PRON
admet-2626	199	8	;	;	PUNCT
admet-2626	199	9	b	b	X
admet-2626	199	10	a	a	DET
admet-2626	199	11	=	=	PUNCT
admet-2626	199	12	acid	acid	NOUN
admet-2626	199	13	,	,	PUNCT
admet-2626	199	14	b	b	NOUN
admet-2626	199	15	=	=	SYM
admet-2626	199	16	base	base	NOUN
admet-2626	199	17	,	,	PUNCT
admet-2626	199	18	x	x	PUNCT
admet-2626	199	19	=	=	SYM
admet-2626	199	20	ampholyte	ampholyte	ADJ
admet-2626	199	21	.	.	PUNCT
admet-2626	200	1	ci	ci	NOUN
admet-2626	200	2	in	in	ADP
admet-2626	200	3	neutral	neutral	ADJ
admet-2626	200	4	-	-	PUNCT
admet-2626	200	5	drug	drug	NOUN
admet-2626	200	6	saturated	saturate	VERB
admet-2626	200	7	water	water	NOUN
admet-2626	201	1	;	;	PUNCT
admet-2626	201	2	dtotal	dtotal	NOUN
admet-2626	201	3	added	add	VERB
admet-2626	201	4	9.5	9.5	NUM
admet-2626	201	5	g	g	NOUN
admet-2626	201	6	/	/	SYM
admet-2626	201	7	ml	ml	X
admet-2626	201	8	(	(	PUNCT
admet-2626	201	9	10	10	NUM
admet-2626	201	10	-	-	ADJ
admet-2626	201	11	fold	fold	ADJ
admet-2626	201	12	excess	excess	NOUN
admet-2626	201	13	over	over	ADP
admet-2626	201	14	solubility	solubility	NOUN
admet-2626	201	15	value	value	NOUN
admet-2626	201	16	)	)	PUNCT
admet-2626	201	17	;	;	PUNCT
admet-2626	201	18	etotal	etotal	PROPN
admet-2626	201	19	added	add	VERB
admet-2626	201	20	1.9	1.9	NUM
admet-2626	201	21	g	g	NOUN
admet-2626	201	22	/	/	SYM
admet-2626	201	23	ml	ml	PROPN
admet-2626	201	24	(	(	PUNCT
admet-2626	201	25	2	2	NUM
admet-2626	201	26	-	-	ADJ
admet-2626	201	27	fold	fold	ADJ
admet-2626	201	28	excess	excess	NOUN
admet-2626	201	29	)	)	PUNCT
admet-2626	201	30	;	;	PUNCT
admet-2626	201	31	ftotal	ftotal	PROPN
admet-2626	201	32	added	add	VERB
admet-2626	201	33	1.2	1.2	NUM
admet-2626	201	34	g	g	NOUN
admet-2626	201	35	/	/	SYM
admet-2626	201	36	ml	ml	PROPN
admet-2626	201	37	(	(	PUNCT
admet-2626	201	38	2	2	NUM
admet-2626	201	39	-	-	ADJ
admet-2626	201	40	fold	fold	ADJ
admet-2626	201	41	excess	excess	NOUN
admet-2626	201	42	over	over	ADP
admet-2626	201	43	solubility	solubility	NOUN
admet-2626	201	44	value	value	NOUN
admet-2626	201	45	)	)	PUNCT
admet-2626	201	46	;	;	PUNCT
admet-2626	201	47	gtotal	gtotal	NOUN
admet-2626	201	48	added	add	VERB
admet-2626	201	49	0.6	0.6	NUM
admet-2626	201	50	g	g	NOUN
admet-2626	201	51	/	/	SYM
admet-2626	201	52	ml	ml	PROPN
admet-2626	201	53	(	(	PUNCT
admet-2626	201	54	1.1	1.1	NUM
admet-2626	201	55	-	-	ADJ
admet-2626	201	56	fold	fold	ADJ
admet-2626	201	57	excess	excess	NOUN
admet-2626	201	58	)	)	PUNCT
admet-2626	201	59	.	.	PUNCT
admet-2626	202	1	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	202	2	a.	a.	NOUN
admet-2626	202	3	avdeef	avdeef	PROPN
admet-2626	202	4	admet	admet	PROPN
admet-2626	202	5	&	&	CCONJ
admet-2626	202	6	dmpk	dmpk	PROPN
admet-2626	202	7	13(1	13(1	NUM
admet-2626	202	8	)	)	PUNCT
admet-2626	202	9	(	(	PUNCT
admet-2626	202	10	2025	2025	NUM
admet-2626	202	11	)	)	PUNCT
admet-2626	202	12	2626	2626	NUM
admet-2626	202	13	8	8	NUM
admet-2626	202	14	in	in	ADP
admet-2626	202	15	almost	almost	ADV
admet-2626	202	16	all	all	DET
admet-2626	202	17	the	the	DET
admet-2626	202	18	simple	simple	ADJ
admet-2626	202	19	acids	acid	NOUN
admet-2626	202	20	,	,	PUNCT
admet-2626	202	21	bases	basis	NOUN
admet-2626	202	22	,	,	PUNCT
admet-2626	202	23	and	and	CCONJ
admet-2626	202	24	ampholytes	ampholyte	NOUN
admet-2626	202	25	,	,	PUNCT
admet-2626	202	26	the	the	DET
admet-2626	202	27	measured	measured	ADJ
admet-2626	202	28	solubility	solubility	NOUN
admet-2626	202	29	was	be	AUX
admet-2626	202	30	slightly	slightly	ADV
admet-2626	202	31	higher	high	ADJ
admet-2626	202	32	than	than	ADP
admet-2626	202	33	the	the	DET
admet-2626	202	34	value	value	NOUN
admet-2626	202	35	harmonized	harmonize	VERB
admet-2626	202	36	to	to	PART
admet-2626	202	37	iref	iref	VERB
admet-2626	202	38	,	,	PUNCT
admet-2626	202	39	i.e.	i.e.	X
admet-2626	202	40	the	the	DET
admet-2626	202	41	presence	presence	NOUN
admet-2626	202	42	of	of	ADP
admet-2626	202	43	salt	salt	NOUN
admet-2626	202	44	lowers	lower	VERB
admet-2626	202	45	water	water	NOUN
admet-2626	202	46	solubility	solubility	NOUN
admet-2626	202	47	at	at	ADP
admet-2626	202	48	iref	iref	NOUN
admet-2626	202	49	due	due	ADP
admet-2626	202	50	to	to	ADP
admet-2626	202	51	activity	activity	NOUN
admet-2626	202	52	effects	effect	NOUN
admet-2626	202	53	.	.	PUNCT
admet-2626	203	1	in	in	ADP
admet-2626	203	2	the	the	DET
admet-2626	203	3	case	case	NOUN
admet-2626	203	4	of	of	ADP
admet-2626	203	5	lysine	lysine	NOUN
admet-2626	203	6	,	,	PUNCT
admet-2626	203	7	the	the	DET
admet-2626	203	8	presence	presence	NOUN
admet-2626	203	9	of	of	ADP
admet-2626	203	10	salt	salt	NOUN
admet-2626	203	11	elevates	elevate	VERB
admet-2626	203	12	the	the	DET
admet-2626	203	13	solubility	solubility	NOUN
admet-2626	203	14	in	in	ADP
admet-2626	203	15	water	water	NOUN
admet-2626	203	16	.	.	PUNCT
admet-2626	204	1	these	these	DET
admet-2626	204	2	trends	trend	NOUN
admet-2626	204	3	will	will	AUX
admet-2626	204	4	be	be	AUX
admet-2626	204	5	graphically	graphically	ADV
admet-2626	204	6	illustrated	illustrate	VERB
admet-2626	204	7	below	below	ADV
admet-2626	204	8	for	for	ADP
admet-2626	204	9	a	a	DET
admet-2626	204	10	few	few	ADJ
admet-2626	204	11	of	of	ADP
admet-2626	204	12	the	the	DET
admet-2626	204	13	substances	substance	NOUN
admet-2626	204	14	studied	study	VERB
admet-2626	204	15	.	.	PUNCT
admet-2626	205	1	the	the	DET
admet-2626	205	2	average	average	ADJ
admet-2626	205	3	values	value	NOUN
admet-2626	205	4	(	(	PUNCT
admet-2626	205	5	±	±	NOUN
admet-2626	205	6	standard	standard	ADJ
admet-2626	205	7	deviations	deviation	NOUN
admet-2626	205	8	)	)	PUNCT
admet-2626	205	9	of	of	ADP
admet-2626	205	10	salting	salt	VERB
admet-2626	205	11	-	-	PUNCT
admet-2626	205	12	out	out	ADP
admet-2626	205	13	coefficients	coefficient	NOUN
admet-2626	205	14	,	,	PUNCT
admet-2626	205	15	ksalt	ksalt	NOUN
admet-2626	205	16	(	(	PUNCT
admet-2626	205	17	tables	table	NOUN
admet-2626	205	18	2	2	NUM
admet-2626	205	19	to	to	PART
admet-2626	205	20	4	4	NUM
admet-2626	205	21	,	,	PUNCT
admet-2626	205	22	estimated	estimate	VERB
admet-2626	205	23	using	use	VERB
admet-2626	205	24	eq	eq	NOUN
admet-2626	205	25	.	.	PUNCT
admet-2626	205	26	(	(	PUNCT
admet-2626	205	27	a5b	a5b	NOUN
admet-2626	205	28	)	)	PUNCT
admet-2626	205	29	)	)	PUNCT
admet-2626	205	30	,	,	PUNCT
admet-2626	205	31	are	be	AUX
admet-2626	205	32	0.28	0.28	NUM
admet-2626	205	33	±	±	NUM
admet-2626	205	34	0.14	0.14	NUM
admet-2626	205	35	(	(	PUNCT
admet-2626	205	36	ampholytes	ampholyte	NOUN
admet-2626	205	37	)	)	PUNCT
admet-2626	205	38	,	,	PUNCT
admet-2626	205	39	0.29	0.29	NUM
admet-2626	205	40	±	±	NUM
admet-2626	205	41	0.13	0.13	NUM
admet-2626	205	42	(	(	PUNCT
admet-2626	205	43	acids	acid	NOUN
admet-2626	205	44	,	,	PUNCT
admet-2626	205	45	first	first	ADJ
admet-2626	205	46	8	8	NUM
admet-2626	205	47	in	in	ADP
admet-2626	205	48	table	table	NOUN
admet-2626	205	49	2	2	NUM
admet-2626	205	50	)	)	PUNCT
admet-2626	205	51	,	,	PUNCT
admet-2626	205	52	and	and	CCONJ
admet-2626	205	53	0.40	0.40	NUM
admet-2626	205	54	±	±	NUM
admet-2626	205	55	0.17	0.17	NUM
admet-2626	205	56	m-1	m-1	X
admet-2626	205	57	(	(	PUNCT
admet-2626	205	58	bases	basis	NOUN
admet-2626	205	59	)	)	PUNCT
admet-2626	205	60	.	.	PUNCT
admet-2626	206	1	the	the	DET
admet-2626	206	2	average	average	ADJ
admet-2626	206	3	values	value	NOUN
admet-2626	206	4	are	be	AUX
admet-2626	206	5	notably	notably	ADV
admet-2626	206	6	lower	low	ADJ
admet-2626	206	7	at	at	ADP
admet-2626	206	8	0.06	0.06	NUM
admet-2626	206	9	±	±	NUM
admet-2626	206	10	0.06	0.06	NUM
admet-2626	206	11	for	for	ADP
admet-2626	206	12	the	the	DET
admet-2626	206	13	benzene	benzene	NOUN
admet-2626	206	14	polycarboxylic	polycarboxylic	ADJ
admet-2626	206	15	acid	acid	NOUN
admet-2626	206	16	series	series	NOUN
admet-2626	206	17	,	,	PUNCT
admet-2626	206	18	particularly	particularly	ADV
admet-2626	206	19	in	in	ADP
admet-2626	206	20	the	the	DET
admet-2626	206	21	cases	case	NOUN
admet-2626	206	22	of	of	ADP
admet-2626	206	23	three	three	NUM
admet-2626	206	24	or	or	CCONJ
admet-2626	206	25	more	more	ADV
admet-2626	206	26	carboxylic	carboxylic	ADJ
admet-2626	206	27	acid	acid	NOUN
admet-2626	206	28	substituents	substituent	NOUN
admet-2626	206	29	.	.	PUNCT
admet-2626	207	1	table	table	NOUN
admet-2626	207	2	2	2	NUM
admet-2626	207	3	.	.	PUNCT
admet-2626	208	1	analysis	analysis	NOUN
admet-2626	208	2	results	result	NOUN
admet-2626	208	3	of	of	ADP
admet-2626	208	4	solubility	solubility	NOUN
admet-2626	208	5	of	of	ADP
admet-2626	208	6	ionizable	ionizable	ADJ
admet-2626	208	7	acids	acid	NOUN
admet-2626	208	8	in	in	ADP
admet-2626	208	9	water	water	NOUN
admet-2626	208	10	(	(	PUNCT
admet-2626	208	11	iref	iref	NOUN
admet-2626	208	12	=	=	PUNCT
admet-2626	208	13	150	150	NUM
admet-2626	208	14	mm	mm	NOUN
admet-2626	208	15	)	)	PUNCT
admet-2626	208	16	weak	weak	ADJ
admet-2626	208	17	acids	acid	NOUN
admet-2626	208	18	log	log	NOUN
admet-2626	208	19	(	(	PUNCT
admet-2626	208	20	sw	sw	PROPN
admet-2626	208	21	lit	light	VERB
admet-2626	208	22	/	/	SYM
admet-2626	208	23	m	m	NOUN
admet-2626	208	24	)	)	PUNCT
admet-2626	208	25	sw	sw	PROPN
admet-2626	208	26	lit	light	VERB
admet-2626	208	27	/	/	SYM
admet-2626	208	28	mg	mg	PROPN
admet-2626	208	29	ml-1	ml-1	PRON
admet-2626	209	1	t	t	PROPN
admet-2626	209	2	/	/	PUNCT
admet-2626	209	3	oc	oc	NOUN
admet-2626	209	4	ref	ref	NOUN
admet-2626	209	5	.	.	PUNCT
admet-2626	210	1	ksalt	ksalt	VERB
admet-2626	210	2	a	a	DET
admet-2626	210	3	phw	phw	NOUN
admet-2626	210	4	log	log	NOUN
admet-2626	210	5	(	(	PUNCT
admet-2626	210	6	s0	s0	PROPN
admet-2626	210	7	ref/	ref/	PROPN
admet-2626	210	8	m	m	PROPN
admet-2626	210	9	)	)	PUNCT
admet-2626	210	10	log	log	NOUN
admet-2626	210	11	(	(	PUNCT
admet-2626	210	12	s0	s0	PROPN
admet-2626	210	13	i	i	PROPN
admet-2626	210	14	/	/	SYM
admet-2626	210	15	m	m	VERB
admet-2626	210	16	)	)	PUNCT
admet-2626	211	1	i	i	PRON
admet-2626	211	2	/	/	SYM
admet-2626	211	3	mm	mm	PROPN
admet-2626	211	4	crocetin	crocetin	NOUN
admet-2626	211	5	-5.74	-5.74	VERB
admet-2626	211	6	0.0006	0.0006	NUM
admet-2626	211	7	23	23	NUM
admet-2626	212	1	[	[	X
admet-2626	212	2	18	18	NUM
admet-2626	212	3	]	]	PUNCT
admet-2626	212	4	0.38	0.38	NUM
admet-2626	212	5	5.56	5.56	NUM
admet-2626	212	6	-7.04	-7.04	NUM
admet-2626	212	7	-6.99	-6.99	NOUN
admet-2626	212	8	0.004	0.004	NUM
admet-2626	212	9	isotretinoin	isotretinoin	PROPN
admet-2626	212	10	-4.77	-4.77	NUM
admet-2626	212	11	0.005	0.005	NUM
admet-2626	212	12	25	25	NUM
admet-2626	213	1	[	[	X
admet-2626	213	2	19	19	NUM
admet-2626	213	3	]	]	SYM
admet-2626	213	4	0.46	0.46	NUM
admet-2626	213	5	5.02	5.02	NUM
admet-2626	213	6	-5.26	-5.26	DET
admet-2626	213	7	-5.19	-5.19	NUM
admet-2626	213	8	0.011	0.011	NUM
admet-2626	213	9	quercetin	quercetin	NOUN
admet-2626	213	10	-4.07	-4.07	NOUN
admet-2626	213	11	0.026	0.026	NUM
admet-2626	213	12	23	23	NUM
admet-2626	214	1	[	[	X
admet-2626	214	2	20	20	NUM
admet-2626	214	3	]	]	PUNCT
admet-2626	214	4	0.11	0.11	NUM
admet-2626	214	5	6.07	6.07	NUM
admet-2626	214	6	-4.11	-4.11	NOUN
admet-2626	214	7	-4.09	-4.09	NUM
admet-2626	214	8	0.004	0.004	NUM
admet-2626	214	9	indomethacin	indomethacin	VERB
admet-2626	214	10	-4.14	-4.14	DET
admet-2626	214	11	0.026	0.026	NUM
admet-2626	214	12	37	37	NUM
admet-2626	214	13	[	[	X
admet-2626	214	14	17	17	NUM
admet-2626	214	15	]	]	SYM
admet-2626	214	16	0.34	0.34	NUM
admet-2626	214	17	4.39	4.39	NUM
admet-2626	214	18	-4.55	-4.55	DET
admet-2626	214	19	-4.50	-4.50	PROPN
admet-2626	214	20	0.046	0.046	NUM
admet-2626	214	21	glibenclamide	glibenclamide	NOUN
admet-2626	214	22	-4.18	-4.18	NUM
admet-2626	214	23	0.033	0.033	NUM
admet-2626	214	24	37	37	NUM
admet-2626	214	25	[	[	X
admet-2626	214	26	17	17	NUM
admet-2626	214	27	]	]	SYM
admet-2626	214	28	0.41	0.41	NUM
admet-2626	214	29	4.81	4.81	NUM
admet-2626	214	30	-4.33	-4.33	NUM
admet-2626	214	31	-4.26	-4.26	NUM
admet-2626	214	32	0.017	0.017	NUM
admet-2626	214	33	phenytoin	phenytoin	NOUN
admet-2626	214	34	-3.65	-3.65	ADP
admet-2626	214	35	0.056	0.056	NUM
admet-2626	214	36	37	37	NUM
admet-2626	214	37	[	[	X
admet-2626	214	38	17	17	NUM
admet-2626	214	39	]	]	PUNCT
admet-2626	214	40	0.25	0.25	NUM
admet-2626	214	41	5.14	5.14	NUM
admet-2626	214	42	-3.69	-3.69	NUM
admet-2626	214	43	-3.66	-3.66	NUM
admet-2626	214	44	0.005	0.005	NUM
admet-2626	214	45	naproxen	naproxen	NOUN
admet-2626	214	46	-3.38	-3.38	NUM
admet-2626	214	47	0.097	0.097	NUM
admet-2626	214	48	37	37	NUM
admet-2626	215	1	[	[	X
admet-2626	215	2	17	17	NUM
admet-2626	215	3	]	]	PUNCT
admet-2626	215	4	0.27	0.27	NUM
admet-2626	215	5	4.00	4.00	NUM
admet-2626	215	6	-3.55	-3.55	NUM
admet-2626	215	7	-3.51	-3.51	NUM
admet-2626	215	8	0.112	0.112	NUM
admet-2626	215	9	acetaminophen	acetaminophen	NOUN
admet-2626	215	10	-0.85	-0.85	NOUN
admet-2626	215	11	21	21	NUM
admet-2626	215	12	37	37	NUM
admet-2626	216	1	[	[	X
admet-2626	216	2	17	17	NUM
admet-2626	216	3	]	]	SYM
admet-2626	216	4	0.12	0.12	NUM
admet-2626	216	5	5.06	5.06	NUM
admet-2626	216	6	-0.87	-0.87	NUM
admet-2626	216	7	-0.85	-0.85	NOUN
admet-2626	216	8	0.010	0.010	NUM
admet-2626	216	9	benzoic	benzoic	NOUN
admet-2626	216	10	acid	acid	NOUN
admet-2626	216	11	-1.55	-1.55	NOUN
admet-2626	216	12	3.5	3.5	NUM
admet-2626	216	13	25	25	NUM
admet-2626	217	1	[	[	X
admet-2626	217	2	16	16	NUM
admet-2626	217	3	]	]	PUNCT
admet-2626	217	4	0.15	0.15	NUM
admet-2626	217	5	2.92	2.92	NUM
admet-2626	217	6	-1.59	-1.59	NUM
admet-2626	217	7	-1.57	-1.57	PROPN
admet-2626	217	8	1.4	1.4	NUM
admet-2626	217	9	2	2	NUM
admet-2626	217	10	-	-	PUNCT
admet-2626	217	11	phthalic	phthalic	ADJ
admet-2626	217	12	acid	acid	NOUN
admet-2626	217	13	-1.36	-1.36	NUM
admet-2626	217	14	7.3	7.3	NUM
admet-2626	217	15	25	25	NUM
admet-2626	218	1	[	[	X
admet-2626	218	2	16	16	NUM
admet-2626	218	3	]	]	PUNCT
admet-2626	218	4	0.11	0.11	NUM
admet-2626	218	5	2.20	2.20	NUM
admet-2626	218	6	-1.46	-1.46	NOUN
admet-2626	218	7	-1.44	-1.44	ADJ
admet-2626	218	8	7.6	7.6	NUM
admet-2626	218	9	trimellitic	trimellitic	PROPN
admet-2626	218	10	acidb	acidb	PROPN
admet-2626	218	11	-1.00	-1.00	NUM
admet-2626	218	12	21	21	NUM
admet-2626	218	13	25	25	NUM
admet-2626	219	1	[	[	X
admet-2626	219	2	16	16	NUM
admet-2626	219	3	]	]	SYM
admet-2626	219	4	0.08	0.08	NUM
admet-2626	219	5	1.82	1.82	NUM
admet-2626	219	6	-1.10	-1.10	NOUN
admet-2626	219	7	-1.09	-1.09	NUM
admet-2626	219	8	19	19	NUM
admet-2626	219	9	hemimellitic	hemimellitic	ADJ
admet-2626	219	10	acidb	acidb	VERB
admet-2626	219	11	-0.62	-0.62	NUM
admet-2626	219	12	51	51	NUM
admet-2626	219	13	25	25	NUM
admet-2626	220	1	[	[	X
admet-2626	220	2	16	16	NUM
admet-2626	220	3	]	]	SYM
admet-2626	220	4	0.08	0.08	NUM
admet-2626	220	5	1.73	1.73	NUM
admet-2626	220	6	-0.67	-0.67	NUM
admet-2626	220	7	-0.66	-0.66	NUM
admet-2626	220	8	23	23	NUM
admet-2626	220	9	pyromellitic	pyromellitic	NOUN
admet-2626	220	10	acidc	acidc	ADP
admet-2626	220	11	-1.37	-1.37	PROPN
admet-2626	220	12	11	11	NUM
admet-2626	220	13	25	25	NUM
admet-2626	221	1	[	[	X
admet-2626	221	2	16	16	NUM
admet-2626	221	3	]	]	SYM
admet-2626	221	4	0.04	0.04	NUM
admet-2626	221	5	1.79	1.79	NUM
admet-2626	221	6	-1.61	-1.61	ADJ
admet-2626	221	7	-1.61	-1.61	NUM
admet-2626	221	8	20	20	NUM
admet-2626	221	9	mellophanic	mellophanic	NOUN
admet-2626	221	10	acidc	acidc	ADP
admet-2626	221	11	0.02	0.02	NUM
admet-2626	221	12	264	264	NUM
admet-2626	221	13	25	25	NUM
admet-2626	222	1	[	[	X
admet-2626	222	2	16	16	NUM
admet-2626	222	3	]	]	SYM
admet-2626	222	4	0.04	0.04	NUM
admet-2626	222	5	1.14	1.14	NUM
admet-2626	222	6	-0.02	-0.02	NUM
admet-2626	222	7	-0.02	-0.02	NUM
admet-2626	222	8	102	102	NUM
admet-2626	222	9	benzenepentacarboxylic	benzenepentacarboxylic	NOUN
admet-2626	222	10	acid	acid	NOUN
admet-2626	222	11	-0.05	-0.05	NUM
admet-2626	222	12	271	271	NUM
admet-2626	222	13	25	25	NUM
admet-2626	223	1	[	[	X
admet-2626	223	2	16	16	NUM
admet-2626	223	3	]	]	PUNCT
admet-2626	223	4	0.00	0.00	NUM
admet-2626	223	5	1.06	1.06	NUM
admet-2626	223	6	-0.11	-0.11	NUM
admet-2626	223	7	-0.11	-0.11	NUM
admet-2626	223	8	128	128	NUM
admet-2626	223	9	mellitic	mellitic	ADJ
admet-2626	223	10	acidd	acidd	NOUN
admet-2626	223	11	(	(	PUNCT
admet-2626	223	12	10	10	NUM
admet-2626	223	13	-	-	ADJ
admet-2626	223	14	fold	fold	ADJ
admet-2626	223	15	excess	excess	NOUN
admet-2626	223	16	)	)	PUNCT
admet-2626	223	17	0.45	0.45	NUM
admet-2626	223	18	988	988	NUM
admet-2626	223	19	25	25	NUM
admet-2626	224	1	[	[	X
admet-2626	224	2	16	16	NUM
admet-2626	224	3	]	]	SYM
admet-2626	224	4	-0.04	-0.04	NUM
admet-2626	224	5	0.40	0.40	NUM
admet-2626	224	6	0.32	0.32	NUM
admet-2626	224	7	0.33	0.33	NUM
admet-2626	224	8	381	381	NUM
admet-2626	224	9	mellitic	mellitic	ADJ
admet-2626	224	10	acidd	acidd	NOUN
admet-2626	224	11	(	(	PUNCT
admet-2626	224	12	2	2	NUM
admet-2626	224	13	-	-	ADJ
admet-2626	224	14	fold	fold	ADJ
admet-2626	224	15	excess	excess	NOUN
admet-2626	224	16	)	)	PUNCT
admet-2626	224	17	0.36	0.36	NUM
admet-2626	224	18	0.36	0.36	NUM
admet-2626	224	19	0.37	0.37	NUM
admet-2626	224	20	485	485	NUM
admet-2626	224	21	acalculated	acalculate	VERB
admet-2626	224	22	using	use	VERB
admet-2626	224	23	eq	eq	NOUN
admet-2626	224	24	.	.	PUNCT
admet-2626	225	1	(	(	PUNCT
admet-2626	225	2	a5b	a5b	PROPN
admet-2626	225	3	)	)	PUNCT
admet-2626	225	4	;	;	PUNCT
admet-2626	225	5	btricarboxyilic	btricarboxyilic	ADJ
admet-2626	225	6	acid	acid	NOUN
admet-2626	225	7	;	;	PUNCT
admet-2626	225	8	ctetracarboxylic	ctetracarboxylic	ADJ
admet-2626	225	9	acid	acid	NOUN
admet-2626	225	10	;	;	PUNCT
admet-2626	225	11	dhexacarboxylic	dhexacarboxylic	ADJ
admet-2626	225	12	acid	acid	NOUN
admet-2626	225	13	.	.	PUNCT
admet-2626	226	1	table	table	NOUN
admet-2626	226	2	3	3	NUM
admet-2626	226	3	.	.	PUNCT
admet-2626	227	1	analysis	analysis	NOUN
admet-2626	227	2	results	result	NOUN
admet-2626	227	3	of	of	ADP
admet-2626	227	4	solubility	solubility	NOUN
admet-2626	227	5	of	of	ADP
admet-2626	227	6	ionizable	ionizable	ADJ
admet-2626	227	7	bases	basis	NOUN
admet-2626	227	8	in	in	ADP
admet-2626	227	9	water	water	NOUN
admet-2626	227	10	(	(	PUNCT
admet-2626	227	11	iref	iref	NOUN
admet-2626	227	12	=	=	PUNCT
admet-2626	227	13	150	150	NUM
admet-2626	227	14	mm	mm	NOUN
admet-2626	227	15	)	)	PUNCT
admet-2626	227	16	weak	weak	ADJ
admet-2626	227	17	bases	basis	NOUN
admet-2626	227	18	log	log	VERB
admet-2626	227	19	(	(	PUNCT
admet-2626	227	20	sw	sw	PROPN
admet-2626	227	21	lit	light	VERB
admet-2626	227	22	/	/	SYM
admet-2626	227	23	m	m	NOUN
admet-2626	227	24	)	)	PUNCT
admet-2626	227	25	sw	sw	PROPN
admet-2626	227	26	lit	light	VERB
admet-2626	227	27	/	/	SYM
admet-2626	227	28	mg	mg	PROPN
admet-2626	227	29	ml-1	ml-1	PRON
admet-2626	228	1	t	t	PROPN
admet-2626	228	2	/	/	PUNCT
admet-2626	228	3	°	°	PROPN
admet-2626	228	4	c	c	NOUN
admet-2626	228	5	ref	ref	NOUN
admet-2626	228	6	.	.	PUNCT
admet-2626	229	1	ksalt	ksalt	PROPN
admet-2626	229	2	/	/	SYM
admet-2626	229	3	m-1	m-1	PROPN
admet-2626	229	4	phw	phw	NOUN
admet-2626	229	5	log	log	NOUN
admet-2626	229	6	(	(	PUNCT
admet-2626	229	7	s0	s0	PROPN
admet-2626	229	8	ref	ref	PROPN
admet-2626	229	9	/	/	SYM
admet-2626	229	10	m	m	NOUN
admet-2626	229	11	)	)	PUNCT
admet-2626	229	12	log	log	NOUN
admet-2626	229	13	(	(	PUNCT
admet-2626	229	14	s0	s0	PROPN
admet-2626	229	15	i	i	PROPN
admet-2626	229	16	/	/	SYM
admet-2626	229	17	m	m	VERB
admet-2626	229	18	)	)	PUNCT
admet-2626	230	1	i	i	PRON
admet-2626	230	2	/	/	SYM
admet-2626	230	3	mm	mm	INTJ
admet-2626	230	4	atenolol	atenolol	PROPN
admet-2626	230	5	-1.09	-1.09	VERB
admet-2626	230	6	22	22	NUM
admet-2626	230	7	37	37	NUM
admet-2626	231	1	[	[	X
admet-2626	231	2	26	26	NUM
admet-2626	231	3	]	]	SYM
admet-2626	231	4	0.24	0.24	NUM
admet-2626	231	5	10.82	10.82	NUM
admet-2626	231	6	-1.13	-1.13	NOUN
admet-2626	231	7	-1.09	-1.09	PROPN
admet-2626	231	8	1.7	1.7	NUM
admet-2626	231	9	bedaquiline	bedaquiline	NOUN
admet-2626	231	10	-5.62	-5.62	NOUN
admet-2626	231	11	0.0013	0.0013	NUM
admet-2626	231	12	23	23	NUM
admet-2626	232	1	[	[	X
admet-2626	232	2	21	21	NUM
admet-2626	232	3	]	]	SYM
admet-2626	232	4	0.58	0.58	NUM
admet-2626	232	5	8.32	8.32	NUM
admet-2626	232	6	-6.25	-6.25	NOUN
admet-2626	232	7	-6.16	-6.16	NUM
admet-2626	232	8	0.002	0.002	NUM
admet-2626	232	9	brigatinib	brigatinib	NOUN
admet-2626	232	10	-1.73	-1.73	NUM
admet-2626	232	11	11	11	NUM
admet-2626	232	12	23	23	NUM
admet-2626	233	1	[	[	X
admet-2626	233	2	25	25	NUM
admet-2626	233	3	]	]	PUNCT
admet-2626	233	4	0.58	0.58	NUM
admet-2626	233	5	10.16	10.16	NUM
admet-2626	233	6	-1.82	-1.82	NUM
admet-2626	233	7	-1.73	-1.73	NUM
admet-2626	233	8	0.12	0.12	NUM
admet-2626	233	9	carvedilol	carvedilol	NOUN
admet-2626	233	10	-4.10	-4.10	NUM
admet-2626	233	11	0.032	0.032	NUM
admet-2626	233	12	37	37	NUM
admet-2626	234	1	[	[	X
admet-2626	234	2	17	17	NUM
admet-2626	234	3	]	]	SYM
admet-2626	234	4	0.37	0.37	NUM
admet-2626	234	5	8.62	8.62	NUM
admet-2626	234	6	-4.21	-4.21	PROPN
admet-2626	234	7	-4.16	-4.16	PROPN
admet-2626	234	8	0.009	0.009	NUM
admet-2626	234	9	emtricitibine	emtricitibine	NOUN
admet-2626	234	10	-0.38	-0.38	PROPN
admet-2626	234	11	104	104	NUM
admet-2626	234	12	25	25	NUM
admet-2626	235	1	[	[	X
admet-2626	235	2	19	19	NUM
admet-2626	235	3	]	]	PUNCT
admet-2626	235	4	0.14	0.14	NUM
admet-2626	235	5	8.15	8.15	NUM
admet-2626	235	6	-0.40	-0.40	NOUN
admet-2626	235	7	-0.38	-0.38	PROPN
admet-2626	235	8	0.001	0.001	NUM
admet-2626	235	9	imatinib	imatinib	NOUN
admet-2626	235	10	-4.69	-4.69	NOUN
admet-2626	235	11	0.010	0.010	NUM
admet-2626	235	12	23	23	NUM
admet-2626	236	1	[	[	X
admet-2626	236	2	24	24	NUM
admet-2626	236	3	]	]	PUNCT
admet-2626	236	4	0.46	0.46	NUM
admet-2626	236	5	8.65	8.65	NUM
admet-2626	236	6	-4.85	-4.85	X
admet-2626	236	7	-4.78	-4.78	NOUN
admet-2626	236	8	0.004	0.004	NUM
admet-2626	236	9	imiquimod	imiquimod	ADJ
admet-2626	236	10	-4.60	-4.60	PROPN
admet-2626	236	11	0.0061	0.0061	NUM
admet-2626	236	12	25	25	NUM
admet-2626	237	1	[	[	X
admet-2626	237	2	23	23	NUM
admet-2626	237	3	]	]	SYM
admet-2626	237	4	0.28	0.28	NUM
admet-2626	237	5	7.97	7.97	NUM
admet-2626	237	6	-4.65	-4.65	DET
admet-2626	237	7	-4.61	-4.61	NOUN
admet-2626	237	8	0.001	0.001	NUM
admet-2626	237	9	ketoconazole	ketoconazole	NOUN
admet-2626	237	10	-4.82	-4.82	NUM
admet-2626	237	11	0.0080	0.0080	NUM
admet-2626	237	12	37	37	NUM
admet-2626	237	13	[	[	X
admet-2626	237	14	17	17	NUM
admet-2626	237	15	]	]	PUNCT
admet-2626	237	16	0.50	0.50	NUM
admet-2626	237	17	7.48	7.48	NUM
admet-2626	237	18	-4.92	-4.92	NUM
admet-2626	237	19	-4.84	-4.84	NUM
admet-2626	237	20	0.001	0.001	NUM
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admet-2626	237	24	37	37	NUM
admet-2626	237	25	[	[	X
admet-2626	237	26	17	17	NUM
admet-2626	237	27	]	]	PUNCT
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admet-2626	237	36	23	23	NUM
admet-2626	238	1	[	[	X
admet-2626	238	2	22	22	NUM
admet-2626	238	3	]	]	PUNCT
admet-2626	238	4	0.64	0.64	NUM
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admet-2626	238	7	-5.96	-5.96	NUM
admet-2626	238	8	0.004	0.004	NUM
admet-2626	238	9	table	table	NOUN
admet-2626	238	10	4	4	NUM
admet-2626	238	11	.	.	PUNCT
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admet-2626	239	2	results	result	NOUN
admet-2626	239	3	of	of	ADP
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admet-2626	239	5	of	of	ADP
admet-2626	239	6	ampholytes	ampholyte	NOUN
admet-2626	239	7	in	in	ADP
admet-2626	239	8	water	water	NOUN
admet-2626	239	9	(	(	PUNCT
admet-2626	239	10	iref	iref	NOUN
admet-2626	239	11	=	=	SYM
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admet-2626	239	13	mm	mm	NOUN
admet-2626	239	14	)	)	PUNCT
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admet-2626	239	16	log	log	VERB
admet-2626	239	17	(	(	PUNCT
admet-2626	239	18	sw	sw	PROPN
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admet-2626	239	20	/	/	SYM
admet-2626	239	21	m	m	NOUN
admet-2626	239	22	)	)	PUNCT
admet-2626	240	1	sw	sw	PROPN
admet-2626	240	2	lit	light	VERB
admet-2626	240	3	/	/	SYM
admet-2626	240	4	mg	mg	PROPN
admet-2626	240	5	ml-1	ml-1	PRON
admet-2626	241	1	t	t	PROPN
admet-2626	241	2	/	/	PUNCT
admet-2626	241	3	°	°	PROPN
admet-2626	241	4	c	c	NOUN
admet-2626	241	5	)	)	PUNCT
admet-2626	241	6	ref	ref	NOUN
admet-2626	241	7	.	.	PUNCT
admet-2626	242	1	ksalt	ksalt	PROPN
admet-2626	242	2	/	/	SYM
admet-2626	242	3	m-1	m-1	PROPN
admet-2626	242	4	phw	phw	NOUN
admet-2626	242	5	log	log	NOUN
admet-2626	242	6	(	(	PUNCT
admet-2626	242	7	s0	s0	PROPN
admet-2626	242	8	ref	ref	PROPN
admet-2626	242	9	/	/	SYM
admet-2626	242	10	m	m	NOUN
admet-2626	242	11	)	)	PUNCT
admet-2626	242	12	log	log	NOUN
admet-2626	242	13	(	(	PUNCT
admet-2626	242	14	s0	s0	PROPN
admet-2626	242	15	i	i	PROPN
admet-2626	242	16	/	/	SYM
admet-2626	242	17	m	m	VERB
admet-2626	242	18	)	)	PUNCT
admet-2626	243	1	i	i	PRON
admet-2626	243	2	/	/	SYM
admet-2626	243	3	mm	mm	PROPN
admet-2626	243	4	celecoxib	celecoxib	NOUN
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admet-2626	243	6	0.003	0.003	NUM
admet-2626	243	7	37	37	NUM
admet-2626	243	8	[	[	X
admet-2626	243	9	17	17	NUM
admet-2626	243	10	]	]	SYM
admet-2626	243	11	0.34	0.34	NUM
admet-2626	243	12	6.71	6.71	NUM
admet-2626	243	13	-5.16	-5.16	PROPN
admet-2626	243	14	-5.11	-5.11	NUM
admet-2626	243	15	0.0002	0.0002	NUM
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admet-2626	243	17	-3.08	-3.08	NUM
admet-2626	243	18	0.30	0.30	NUM
admet-2626	243	19	37	37	NUM
admet-2626	244	1	[	[	X
admet-2626	244	2	17	17	NUM
admet-2626	244	3	]	]	SYM
admet-2626	244	4	0.31	0.31	NUM
admet-2626	244	5	7.04	7.04	NUM
admet-2626	244	6	-3.22	-3.22	NOUN
admet-2626	244	7	-3.18	-3.18	VERB
admet-2626	244	8	0.090	0.090	NUM
admet-2626	244	9	lysine	lysine	NOUN
admet-2626	244	10	,	,	PUNCT
admet-2626	244	11	l	l	NOUN
admet-2626	244	12	-	-	PUNCT
admet-2626	244	13	a	a	DET
admet-2626	244	14	0.60	0.60	NUM
admet-2626	244	15	585	585	NUM
admet-2626	244	16	27	27	NUM
admet-2626	245	1	[	[	X
admet-2626	245	2	27	27	NUM
admet-2626	245	3	]	]	PUNCT
admet-2626	245	4	0.10	0.10	NUM
admet-2626	245	5	10.01	10.01	NUM
admet-2626	245	6	0.53	0.53	NUM
admet-2626	245	7	0.47	0.47	NUM
admet-2626	245	8	695	695	NUM
admet-2626	245	9	lysine	lysine	NOUN
admet-2626	245	10	,	,	PUNCT
admet-2626	245	11	l	l	NOUN
admet-2626	245	12	-	-	PROPN
admet-2626	245	13	b	b	PROPN
admet-2626	245	14	9.98	9.98	NUM
admet-2626	245	15	0.50	0.50	NUM
admet-2626	245	16	0.45	0.45	NUM
admet-2626	245	17	612	612	NUM
admet-2626	245	18	mycophenolate	mycophenolate	NOUN
admet-2626	245	19	mofetil	mofetil	NOUN
admet-2626	245	20	-2.93	-2.93	NUM
admet-2626	245	21	0.51	0.51	NUM
admet-2626	245	22	37	37	NUM
admet-2626	245	23	[	[	X
admet-2626	245	24	17	17	NUM
admet-2626	245	25	]	]	SYM
admet-2626	245	26	0.51	0.51	NUM
admet-2626	245	27	7.06	7.06	NUM
admet-2626	245	28	-3.03	-3.03	NOUN
admet-2626	245	29	-2.96	-2.96	NUM
admet-2626	245	30	0.038	0.038	NUM
admet-2626	245	31	piroxicam	piroxicam	NOUN
admet-2626	245	32	-4.02	-4.02	NUM
admet-2626	245	33	0.032	0.032	NUM
admet-2626	245	34	37	37	NUM
admet-2626	245	35	[	[	X
admet-2626	245	36	17	17	NUM
admet-2626	245	37	]	]	SYM
admet-2626	245	38	0.20	0.20	NUM
admet-2626	245	39	4.77	4.77	NUM
admet-2626	245	40	-4.14	-4.14	PRON
admet-2626	245	41	-4.11	-4.11	NUM
admet-2626	245	42	0.019	0.019	NUM
admet-2626	245	43	sulfamethoxazole	sulfamethoxazole	NOUN
admet-2626	245	44	-3.36	-3.36	NOUN
admet-2626	245	45	0.11	0.11	NUM
admet-2626	245	46	37	37	NUM
admet-2626	245	47	[	[	X
admet-2626	245	48	17	17	NUM
admet-2626	245	49	]	]	SYM
admet-2626	245	50	0.20	0.20	NUM
admet-2626	245	51	4.68	4.68	NUM
admet-2626	245	52	-3.42	-3.42	NUM
admet-2626	245	53	-3.39	-3.39	NUM
admet-2626	245	54	0.024	0.024	NUM
admet-2626	245	55	atotal	atotal	NOUN
admet-2626	245	56	added	add	VERB
admet-2626	245	57	1.2	1.2	NUM
admet-2626	245	58	g	g	NOUN
admet-2626	245	59	/	/	SYM
admet-2626	245	60	ml	ml	PROPN
admet-2626	245	61	(	(	PUNCT
admet-2626	245	62	2	2	NUM
admet-2626	245	63	-	-	ADJ
admet-2626	245	64	fold	fold	ADJ
admet-2626	245	65	excess	excess	NOUN
admet-2626	245	66	over	over	ADP
admet-2626	245	67	solubility	solubility	NOUN
admet-2626	245	68	value	value	NOUN
admet-2626	245	69	)	)	PUNCT
admet-2626	245	70	;	;	PUNCT
admet-2626	245	71	btotal	btotal	PROPN
admet-2626	245	72	added	add	VERB
admet-2626	245	73	0.6	0.6	NUM
admet-2626	245	74	g	g	NOUN
admet-2626	245	75	/	/	SYM
admet-2626	245	76	ml	ml	PROPN
admet-2626	245	77	(	(	PUNCT
admet-2626	245	78	1.1	1.1	NUM
admet-2626	245	79	-	-	ADJ
admet-2626	245	80	fold	fold	ADJ
admet-2626	245	81	excess	excess	NOUN
admet-2626	245	82	)	)	PUNCT
admet-2626	245	83	.	.	PUNCT
admet-2626	246	1	salting	salt	VERB
admet-2626	246	2	-	-	PUNCT
admet-2626	246	3	out	out	ADP
admet-2626	246	4	contributions	contribution	NOUN
admet-2626	246	5	to	to	ADP
admet-2626	246	6	shifts	shift	NOUN
admet-2626	246	7	in	in	ADP
admet-2626	246	8	intrinsic	intrinsic	ADJ
admet-2626	246	9	solubility	solubility	NOUN
admet-2626	246	10	at	at	ADP
admet-2626	246	11	different	different	ADJ
admet-2626	246	12	levels	level	NOUN
admet-2626	246	13	of	of	ADP
admet-2626	246	14	ionic	ionic	ADJ
admet-2626	246	15	strength	strength	NOUN
admet-2626	246	16	at	at	ADP
admet-2626	246	17	phw	phw	NOUN
admet-2626	246	18	,	,	PUNCT
admet-2626	246	19	salting	salt	VERB
admet-2626	246	20	-	-	PUNCT
admet-2626	246	21	out	out	ADP
admet-2626	246	22	accounts	account	NOUN
admet-2626	246	23	for	for	ADP
admet-2626	246	24	92	92	NUM
admet-2626	246	25	to	to	PART
admet-2626	246	26	100	100	NUM
admet-2626	246	27	%	%	NOUN
admet-2626	246	28	of	of	ADP
admet-2626	246	29	the	the	DET
admet-2626	246	30	total	total	ADJ
admet-2626	246	31	activity	activity	NOUN
admet-2626	246	32	correction	correction	NOUN
admet-2626	246	33	for	for	ADP
admet-2626	246	34	intrinsic	intrinsic	ADJ
admet-2626	246	35	solubility	solubility	NOUN
admet-2626	246	36	(	(	PUNCT
admet-2626	246	37	i.e.	i.e.	X
admet-2626	246	38	log	log	NOUN
admet-2626	246	39	s0	s0	PROPN
admet-2626	246	40	ref	ref	NOUN
admet-2626	246	41	log	log	NOUN
admet-2626	246	42	s0	s0	PROPN
admet-2626	247	1	i	i	PROPN
admet-2626	248	1	≈	≈	PROPN
admet-2626	248	2	ksalt(iref	ksalt(iref	PROPN
admet-2626	248	3	i	i	PROPN
admet-2626	248	4	)	)	PUNCT
admet-2626	248	5	)	)	PUNCT
admet-2626	249	1	and	and	CCONJ
admet-2626	249	2	eq	eq	NOUN
admet-2626	249	3	.	.	PROPN
admet-2626	249	4	a3	a3	PROPN
admet-2626	249	5	does	do	AUX
admet-2626	249	6	not	not	PART
admet-2626	249	7	contribute	contribute	VERB
admet-2626	249	8	to	to	ADP
admet-2626	249	9	the	the	DET
admet-2626	249	10	shift	shift	NOUN
admet-2626	249	11	in	in	ADP
admet-2626	249	12	log	log	NOUN
admet-2626	249	13	s0	s0	NOUN
admet-2626	249	14	between	between	ADP
admet-2626	249	15	the	the	DET
admet-2626	249	16	measurement	measurement	NOUN
admet-2626	249	17	ionic	ionic	ADJ
admet-2626	249	18	strength	strength	NOUN
admet-2626	249	19	and	and	CCONJ
admet-2626	249	20	the	the	DET
admet-2626	249	21	reference	reference	NOUN
admet-2626	249	22	0.15	0.15	NUM
admet-2626	249	23	m	m	NOUN
admet-2626	249	24	value	value	NOUN
admet-2626	249	25	,	,	PUNCT
admet-2626	249	26	since	since	SCONJ
admet-2626	249	27	the	the	DET
admet-2626	249	28	second	second	ADJ
admet-2626	249	29	and	and	CCONJ
admet-2626	249	30	third	third	ADJ
admet-2626	249	31	terms	term	NOUN
admet-2626	249	32	in	in	ADP
admet-2626	249	33	eq	eq	ADP
admet-2626	249	34	.	.	PUNCT
admet-2626	250	1	(	(	PUNCT
admet-2626	250	2	a3	a3	NOUN
admet-2626	250	3	)	)	PUNCT
admet-2626	250	4	are	be	AUX
admet-2626	250	5	not	not	PART
admet-2626	250	6	significant	significant	ADJ
admet-2626	250	7	at	at	ADP
admet-2626	250	8	these	these	DET
admet-2626	250	9	levels	level	NOUN
admet-2626	250	10	of	of	ADP
admet-2626	250	11	ionic	ionic	ADJ
admet-2626	250	12	strength	strength	NOUN
admet-2626	250	13	.	.	PUNCT
admet-2626	251	1	admet	admet	PROPN
admet-2626	251	2	&	&	CCONJ
admet-2626	251	3	dmpk	dmpk	PROPN
admet-2626	251	4	13(1	13(1	NUM
admet-2626	251	5	)	)	PUNCT
admet-2626	251	6	(	(	PUNCT
admet-2626	251	7	2025	2025	NUM
admet-2626	251	8	)	)	PUNCT
admet-2626	251	9	2626	2626	NUM
admet-2626	251	10	transforming	transform	VERB
admet-2626	251	11	drug	drug	NOUN
admet-2626	251	12	solubility	solubility	NOUN
admet-2626	251	13	measurement	measurement	NOUN
admet-2626	251	14	doi	doi	PROPN
admet-2626	251	15	:	:	PUNCT
admet-2626	251	16	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	251	17	9	9	NUM
admet-2626	251	18	solubility	solubility	NOUN
admet-2626	251	19	-	-	PUNCT
admet-2626	251	20	ph	ph	NOUN
admet-2626	251	21	curves	curve	NOUN
admet-2626	251	22	generated	generate	VERB
admet-2626	251	23	by	by	ADP
admet-2626	251	24	analytic	analytic	ADJ
admet-2626	251	25	continuation	continuation	NOUN
admet-2626	251	26	from	from	ADP
admet-2626	251	27	phw	phw	NOUN
admet-2626	251	28	figure	figure	NOUN
admet-2626	251	29	1	1	NUM
admet-2626	251	30	illustrates	illustrate	VERB
admet-2626	251	31	the	the	DET
admet-2626	251	32	log	log	NOUN
admet-2626	251	33	s	s	NOUN
admet-2626	251	34	-	-	PUNCT
admet-2626	251	35	ph	ph	ADJ
admet-2626	251	36	relationships	relationship	NOUN
admet-2626	251	37	in	in	ADP
admet-2626	251	38	three	three	NUM
admet-2626	251	39	selected	select	VERB
admet-2626	251	40	examples	example	NOUN
admet-2626	251	41	of	of	ADP
admet-2626	251	42	acids	acid	NOUN
admet-2626	251	43	(	(	PUNCT
admet-2626	251	44	shown	show	VERB
admet-2626	251	45	in	in	ADP
admet-2626	251	46	increasing	increase	VERB
admet-2626	251	47	order	order	NOUN
admet-2626	251	48	of	of	ADP
admet-2626	251	49	solubility	solubility	NOUN
admet-2626	251	50	):	):	PUNCT
admet-2626	251	51	crocetin	crocetin	NOUN
admet-2626	251	52	,	,	PUNCT
admet-2626	251	53	glibenclamide	glibenclamide	NOUN
admet-2626	251	54	and	and	CCONJ
admet-2626	251	55	acetaminophen	acetaminophen	NOUN
admet-2626	251	56	.	.	PUNCT
admet-2626	252	1	at	at	ADP
admet-2626	252	2	phw	phw	NOUN
admet-2626	252	3	,	,	PUNCT
admet-2626	252	4	the	the	DET
admet-2626	252	5	ionic	ionic	ADJ
admet-2626	252	6	strength	strength	NOUN
admet-2626	252	7	and	and	CCONJ
admet-2626	252	8	buffer	buffer	NOUN
admet-2626	252	9	capacity	capacity	NOUN
admet-2626	252	10	are	be	AUX
admet-2626	252	11	at	at	ADP
admet-2626	252	12	their	their	PRON
admet-2626	252	13	minimum	minimum	ADJ
admet-2626	252	14	values	value	NOUN
admet-2626	252	15	(	(	PUNCT
admet-2626	252	16	with	with	ADP
admet-2626	252	17	iw	iw	INTJ
admet-2626	252	18	0	0	X
admet-2626	252	19	m	m	NOUN
admet-2626	252	20	,	,	PUNCT
admet-2626	252	21	buffer	buffer	VERB
admet-2626	252	22	capacity	capacity	NOUN
admet-2626	252	23	<	<	X
admet-2626	252	24	1	1	NUM
admet-2626	252	25	mm	mm	NOUN
admet-2626	252	26	/	/	SYM
admet-2626	252	27	ph	ph	NOUN
admet-2626	252	28	)	)	PUNCT
admet-2626	252	29	for	for	ADP
admet-2626	252	30	the	the	DET
admet-2626	252	31	three	three	NUM
admet-2626	252	32	acids	acid	NOUN
admet-2626	252	33	.	.	PUNCT
admet-2626	253	1	as	as	SCONJ
admet-2626	253	2	ph	ph	NOUN
admet-2626	253	3	is	be	AUX
admet-2626	253	4	altered	alter	VERB
admet-2626	253	5	by	by	ADP
admet-2626	253	6	the	the	DET
admet-2626	253	7	addition	addition	NOUN
admet-2626	253	8	of	of	ADP
admet-2626	253	9	titrant	titrant	NOUN
admet-2626	253	10	,	,	PUNCT
admet-2626	253	11	both	both	DET
admet-2626	253	12	properties	property	NOUN
admet-2626	253	13	increase	increase	VERB
admet-2626	253	14	,	,	PUNCT
admet-2626	253	15	particularly	particularly	ADV
admet-2626	253	16	below	below	ADP
admet-2626	253	17	ph	ph	NOUN
admet-2626	253	18	3	3	NUM
admet-2626	253	19	and	and	CCONJ
admet-2626	253	20	above	above	ADP
admet-2626	253	21	ph	ph	X
admet-2626	253	22	8	8	NUM
admet-2626	253	23	.	.	PUNCT
admet-2626	254	1	in	in	ADP
admet-2626	254	2	all	all	DET
admet-2626	254	3	cases	case	NOUN
admet-2626	254	4	in	in	ADP
admet-2626	254	5	figure	figure	NOUN
admet-2626	254	6	1	1	NUM
admet-2626	254	7	,	,	PUNCT
admet-2626	254	8	the	the	DET
admet-2626	254	9	equilibrium	equilibrium	NOUN
admet-2626	254	10	phw	phw	NOUN
admet-2626	254	11	is	be	AUX
admet-2626	254	12	less	less	ADJ
admet-2626	254	13	than	than	ADP
admet-2626	254	14	that	that	PRON
admet-2626	254	15	of	of	ADP
admet-2626	254	16	water	water	NOUN
admet-2626	254	17	(	(	PUNCT
admet-2626	254	18	ph	ph	ADJ
admet-2626	254	19	7	7	ADJ
admet-2626	254	20	)	)	PUNCT
admet-2626	254	21	.	.	PUNCT
admet-2626	255	1	both	both	CCONJ
admet-2626	255	2	the	the	DET
admet-2626	255	3	water	water	NOUN
admet-2626	255	4	solubility	solubility	NOUN
admet-2626	255	5	(	(	PUNCT
admet-2626	255	6	sw	sw	PROPN
admet-2626	255	7	)	)	PUNCT
admet-2626	255	8	and	and	CCONJ
admet-2626	255	9	the	the	DET
admet-2626	255	10	acid	acid	NOUN
admet-2626	255	11	strength	strength	NOUN
admet-2626	255	12	(	(	PUNCT
admet-2626	255	13	pka	pka	NOUN
admet-2626	255	14	)	)	PUNCT
admet-2626	255	15	of	of	ADP
admet-2626	255	16	the	the	DET
admet-2626	255	17	molecule	molecule	NOUN
admet-2626	255	18	play	play	VERB
admet-2626	255	19	a	a	DET
admet-2626	255	20	critical	critical	ADJ
admet-2626	255	21	role	role	NOUN
admet-2626	255	22	,	,	PUNCT
admet-2626	255	23	as	as	SCONJ
admet-2626	255	24	detailed	detailed	ADJ
admet-2626	255	25	in	in	ADP
admet-2626	255	26	the	the	DET
admet-2626	255	27	examples	example	NOUN
admet-2626	255	28	in	in	ADP
admet-2626	255	29	appendix	appendix	ADJ
admet-2626	255	30	c.	c.	NOUN
admet-2626	255	31	consider	consider	VERB
admet-2626	255	32	the	the	DET
admet-2626	255	33	weak	weak	ADJ
admet-2626	255	34	acids	acid	NOUN
admet-2626	255	35	in	in	ADP
admet-2626	255	36	the	the	DET
admet-2626	255	37	figure	figure	NOUN
admet-2626	255	38	.	.	PUNCT
admet-2626	256	1	to	to	PART
admet-2626	256	2	better	well	ADV
admet-2626	256	3	understand	understand	VERB
admet-2626	256	4	the	the	DET
admet-2626	256	5	resulting	result	VERB
admet-2626	256	6	shifts	shift	NOUN
admet-2626	256	7	from	from	ADP
admet-2626	256	8	ph	ph	ADJ
admet-2626	256	9	7	7	ADJ
admet-2626	256	10	to	to	PART
admet-2626	256	11	phw	phw	VERB
admet-2626	256	12	,	,	PUNCT
admet-2626	256	13	it	it	PRON
admet-2626	256	14	is	be	AUX
admet-2626	256	15	helpful	helpful	ADJ
admet-2626	256	16	to	to	PART
admet-2626	256	17	think	think	VERB
admet-2626	256	18	of	of	ADP
admet-2626	256	19	the	the	DET
admet-2626	256	20	weak	weak	ADJ
admet-2626	256	21	acid	acid	NOUN
admet-2626	256	22	as	as	ADP
admet-2626	256	23	a	a	DET
admet-2626	256	24	titrant	titrant	NOUN
admet-2626	256	25	added	add	VERB
admet-2626	256	26	to	to	ADP
admet-2626	256	27	pure	pure	ADJ
admet-2626	256	28	water	water	NOUN
admet-2626	256	29	that	that	PRON
admet-2626	256	30	produces	produce	VERB
admet-2626	256	31	a	a	DET
admet-2626	256	32	certain	certain	ADJ
admet-2626	256	33	shift	shift	NOUN
admet-2626	256	34	in	in	ADP
admet-2626	256	35	water	water	NOUN
admet-2626	256	36	ph	ph	PROPN
admet-2626	256	37	.	.	PROPN
admet-2626	257	1	for	for	ADP
admet-2626	257	2	the	the	DET
admet-2626	257	3	most	most	ADV
admet-2626	257	4	soluble	soluble	ADJ
admet-2626	257	5	of	of	ADP
admet-2626	257	6	the	the	DET
admet-2626	257	7	acids	acid	NOUN
admet-2626	257	8	in	in	ADP
admet-2626	257	9	figure	figure	NOUN
admet-2626	257	10	1	1	NUM
admet-2626	257	11	,	,	PUNCT
admet-2626	257	12	acetaminophen	acetaminophen	NOUN
admet-2626	257	13	,	,	PUNCT
admet-2626	257	14	the	the	DET
admet-2626	257	15	phw	phw	NOUN
admet-2626	257	16	is	be	AUX
admet-2626	257	17	shifted	shift	VERB
admet-2626	257	18	below	below	ADP
admet-2626	257	19	the	the	DET
admet-2626	257	20	pka	pka	NOUN
admet-2626	257	21	by	by	ADP
admet-2626	257	22	4.3	4.3	NUM
admet-2626	257	23	units	unit	NOUN
admet-2626	257	24	.	.	PUNCT
admet-2626	258	1	since	since	SCONJ
admet-2626	258	2	acetaminophen	acetaminophen	NOUN
admet-2626	258	3	is	be	AUX
admet-2626	258	4	quite	quite	ADV
admet-2626	258	5	soluble	soluble	ADJ
admet-2626	258	6	,	,	PUNCT
admet-2626	258	7	enough	enough	ADJ
admet-2626	258	8	of	of	ADP
admet-2626	258	9	the	the	DET
admet-2626	258	10	free	free	ADJ
admet-2626	258	11	acid	acid	NOUN
admet-2626	258	12	dissolves	dissolve	VERB
admet-2626	258	13	and	and	CCONJ
admet-2626	258	14	sufficiently	sufficiently	ADV
admet-2626	258	15	ionizes	ionize	NOUN
admet-2626	258	16	,	,	PUNCT
admet-2626	258	17	to	to	PART
admet-2626	258	18	overcome	overcome	VERB
admet-2626	258	19	the	the	DET
admet-2626	258	20	buffering	buffering	NOUN
admet-2626	258	21	of	of	ADP
admet-2626	258	22	pure	pure	ADJ
admet-2626	258	23	water	water	NOUN
admet-2626	258	24	in	in	ADP
admet-2626	258	25	the	the	DET
admet-2626	258	26	neutral	neutral	ADJ
admet-2626	258	27	ph	ph	ADJ
admet-2626	258	28	domain	domain	NOUN
admet-2626	258	29	.	.	PUNCT
admet-2626	259	1	in	in	ADP
admet-2626	259	2	simulation	simulation	NOUN
admet-2626	259	3	calculations	calculation	NOUN
admet-2626	259	4	,	,	PUNCT
admet-2626	259	5	acetaminophen	acetaminophen	NOUN
admet-2626	259	6	,	,	PUNCT
admet-2626	259	7	when	when	SCONJ
admet-2626	259	8	added	add	VERB
admet-2626	259	9	to	to	ADP
admet-2626	259	10	water	water	NOUN
admet-2626	259	11	,	,	PUNCT
admet-2626	259	12	releases	release	VERB
admet-2626	259	13	0.08	0.08	PROPN
admet-2626	259	14	µmol	µmol	ADV
admet-2626	259	15	of	of	ADP
admet-2626	259	16	h+	h+	X
admet-2626	259	17	per	per	ADP
admet-2626	259	18	ml	ml	NOUN
admet-2626	259	19	of	of	ADP
admet-2626	259	20	solution	solution	NOUN
admet-2626	259	21	,	,	PUNCT
admet-2626	259	22	which	which	PRON
admet-2626	259	23	results	result	VERB
admet-2626	259	24	in	in	ADP
admet-2626	259	25	the	the	DET
admet-2626	259	26	ph	ph	ADJ
admet-2626	259	27	shift	shift	NOUN
admet-2626	259	28	from	from	ADP
admet-2626	259	29	7	7	ADJ
admet-2626	259	30	to	to	ADP
admet-2626	259	31	5	5	NOUN
admet-2626	259	32	,	,	PUNCT
admet-2626	259	33	well	well	ADV
admet-2626	259	34	inside	inside	ADP
admet-2626	259	35	the	the	DET
admet-2626	259	36	minimum	minimum	NOUN
admet-2626	259	37	solubility	solubility	NOUN
admet-2626	259	38	region	region	NOUN
admet-2626	259	39	(	(	PUNCT
admet-2626	259	40	ph	ph	X
admet-2626	259	41	<	<	X
admet-2626	259	42	7	7	NUM
admet-2626	259	43	,	,	PUNCT
admet-2626	259	44	as	as	SCONJ
admet-2626	259	45	dictated	dictate	VERB
admet-2626	259	46	by	by	ADP
admet-2626	259	47	the	the	DET
admet-2626	259	48	acetaminophen	acetaminophen	NOUN
admet-2626	259	49	pka	pka	PROPN
admet-2626	259	50	)	)	PUNCT
admet-2626	259	51	in	in	ADP
admet-2626	259	52	the	the	DET
admet-2626	259	53	log	log	NOUN
admet-2626	259	54	s	s	NOUN
admet-2626	259	55	-	-	PUNCT
admet-2626	259	56	ph	ph	ADJ
admet-2626	259	57	profile	profile	NOUN
admet-2626	259	58	(	(	PUNCT
admet-2626	259	59	fig	fig	NOUN
admet-2626	259	60	.	.	PUNCT
admet-2626	260	1	1c	1c	NOUN
admet-2626	260	2	)	)	PUNCT
admet-2626	260	3	.	.	PUNCT
admet-2626	261	1	the	the	PRON
admet-2626	261	2	lower	low	ADJ
admet-2626	261	3	the	the	DET
admet-2626	261	4	solubility	solubility	NOUN
admet-2626	261	5	of	of	ADP
admet-2626	261	6	the	the	DET
admet-2626	261	7	acid	acid	NOUN
admet-2626	261	8	,	,	PUNCT
admet-2626	261	9	the	the	PRON
admet-2626	261	10	less	less	ADV
admet-2626	261	11	the	the	DET
admet-2626	261	12	acid	acid	NOUN
admet-2626	261	13	impacts	impact	NOUN
admet-2626	261	14	on	on	ADP
admet-2626	261	15	the	the	DET
admet-2626	261	16	shift	shift	NOUN
admet-2626	261	17	in	in	ADP
admet-2626	261	18	phw	phw	NOUN
admet-2626	261	19	from	from	ADP
admet-2626	261	20	ph	ph	PROPN
admet-2626	261	21	~	~	PUNCT
admet-2626	261	22	7	7	NUM
admet-2626	261	23	of	of	ADP
admet-2626	261	24	pure	pure	ADJ
admet-2626	261	25	water	water	NOUN
admet-2626	261	26	.	.	PUNCT
admet-2626	262	1	for	for	ADP
admet-2626	262	2	example	example	NOUN
admet-2626	262	3	,	,	PUNCT
admet-2626	262	4	crocetin	crocetin	NOUN
admet-2626	262	5	would	would	AUX
admet-2626	262	6	need	need	VERB
admet-2626	262	7	to	to	PART
admet-2626	262	8	release	release	VERB
admet-2626	262	9	0.73	0.73	PROPN
admet-2626	262	10	µmol	µmol	ADV
admet-2626	262	11	/	/	SYM
admet-2626	262	12	ml	ml	PROPN
admet-2626	262	13	of	of	ADP
admet-2626	262	14	h+	h+	PUNCT
admet-2626	262	15	to	to	PART
admet-2626	262	16	effect	effect	VERB
admet-2626	262	17	the	the	DET
admet-2626	262	18	ph	ph	ADJ
admet-2626	262	19	shift	shift	NOUN
admet-2626	262	20	from	from	ADP
admet-2626	262	21	7	7	ADJ
admet-2626	262	22	to	to	ADP
admet-2626	262	23	3	3	PROPN
admet-2626	262	24	,	,	PUNCT
admet-2626	262	25	where	where	SCONJ
admet-2626	262	26	the	the	DET
admet-2626	262	27	molecule	molecule	NOUN
admet-2626	262	28	would	would	AUX
admet-2626	262	29	be	be	AUX
admet-2626	262	30	in	in	ADP
admet-2626	262	31	the	the	DET
admet-2626	262	32	intrinsic	intrinsic	ADJ
admet-2626	262	33	(	(	PUNCT
admet-2626	262	34	minimum	minimum	ADJ
admet-2626	262	35	)	)	PUNCT
admet-2626	262	36	solubility	solubility	NOUN
admet-2626	262	37	part	part	NOUN
admet-2626	262	38	of	of	ADP
admet-2626	262	39	the	the	DET
admet-2626	262	40	log	log	NOUN
admet-2626	262	41	s	s	NOUN
admet-2626	262	42	-	-	PUNCT
admet-2626	262	43	ph	ph	ADJ
admet-2626	262	44	curve	curve	NOUN
admet-2626	262	45	(	(	PUNCT
admet-2626	262	46	fig	fig	NOUN
admet-2626	262	47	.	.	PUNCT
admet-2626	263	1	1a	1a	NOUN
admet-2626	263	2	)	)	PUNCT
admet-2626	263	3	.	.	PUNCT
admet-2626	264	1	however	however	ADV
admet-2626	264	2	,	,	PUNCT
admet-2626	264	3	due	due	ADP
admet-2626	264	4	to	to	ADP
admet-2626	264	5	its	its	PRON
admet-2626	264	6	very	very	ADV
admet-2626	264	7	low	low	ADJ
admet-2626	264	8	solubility	solubility	NOUN
admet-2626	264	9	,	,	PUNCT
admet-2626	264	10	only	only	ADV
admet-2626	264	11	about	about	ADV
admet-2626	264	12	0.06	0.06	NUM
admet-2626	264	13	µmol	µmol	NOUN
admet-2626	264	14	/	/	SYM
admet-2626	264	15	ml	ml	PROPN
admet-2626	264	16	of	of	ADP
admet-2626	264	17	h+	h+	X
admet-2626	264	18	are	be	AUX
admet-2626	264	19	released	release	VERB
admet-2626	264	20	,	,	PUNCT
admet-2626	264	21	so	so	ADV
admet-2626	264	22	crocetin	crocetin	NOUN
admet-2626	264	23	can	can	AUX
admet-2626	264	24	not	not	PART
admet-2626	264	25	reach	reach	VERB
admet-2626	264	26	the	the	DET
admet-2626	264	27	intrinsic	intrinsic	ADJ
admet-2626	264	28	solubility	solubility	NOUN
admet-2626	264	29	region	region	NOUN
admet-2626	264	30	in	in	ADP
admet-2626	264	31	the	the	DET
admet-2626	264	32	log	log	NOUN
admet-2626	264	33	s	s	NOUN
admet-2626	264	34	-	-	PUNCT
admet-2626	264	35	ph	ph	ADJ
admet-2626	264	36	profile	profile	NOUN
admet-2626	264	37	(	(	PUNCT
admet-2626	264	38	ph	ph	NOUN
admet-2626	264	39	<3	<3	NOUN
admet-2626	264	40	,	,	PUNCT
admet-2626	264	41	as	as	SCONJ
admet-2626	264	42	defined	define	VERB
admet-2626	264	43	by	by	ADP
admet-2626	264	44	its	its	PRON
admet-2626	264	45	two	two	NUM
admet-2626	264	46	pka	pka	PROPN
admet-2626	264	47	values	value	NOUN
admet-2626	264	48	)	)	PUNCT
admet-2626	264	49	.	.	PUNCT
admet-2626	265	1	the	the	DET
admet-2626	265	2	measured	measure	VERB
admet-2626	265	3	phw	phw	NOUN
admet-2626	265	4	values	value	NOUN
admet-2626	265	5	are	be	AUX
admet-2626	265	6	apt	apt	ADJ
admet-2626	265	7	to	to	PART
admet-2626	265	8	be	be	AUX
admet-2626	265	9	in	in	ADP
admet-2626	265	10	the	the	DET
admet-2626	265	11	diagonal	diagonal	ADJ
admet-2626	265	12	region	region	NOUN
admet-2626	265	13	of	of	ADP
admet-2626	265	14	the	the	DET
admet-2626	265	15	profile	profile	NOUN
admet-2626	265	16	,	,	PUNCT
admet-2626	265	17	as	as	ADP
admet-2626	265	18	in	in	ADP
admet-2626	265	19	the	the	DET
admet-2626	265	20	case	case	NOUN
admet-2626	265	21	of	of	ADP
admet-2626	265	22	the	the	DET
admet-2626	265	23	poorly	poorly	ADV
admet-2626	265	24	soluble	soluble	ADJ
admet-2626	265	25	crocetin	crocetin	NOUN
admet-2626	265	26	,	,	PUNCT
admet-2626	265	27	where	where	SCONJ
admet-2626	265	28	phw	phw	NOUN
admet-2626	265	29	is	be	AUX
admet-2626	265	30	above	above	ADP
admet-2626	265	31	pka1	pka1	PROPN
admet-2626	265	32	by	by	ADP
admet-2626	265	33	0.94	0.94	NUM
admet-2626	265	34	log	log	NOUN
admet-2626	265	35	unit	unit	NOUN
admet-2626	265	36	.	.	PUNCT
admet-2626	266	1	by	by	ADP
admet-2626	266	2	comparison	comparison	NOUN
admet-2626	266	3	,	,	PUNCT
admet-2626	266	4	the	the	DET
admet-2626	266	5	phw	phw	NOUN
admet-2626	266	6	of	of	ADP
admet-2626	266	7	the	the	DET
admet-2626	266	8	more	more	ADV
admet-2626	266	9	soluble	soluble	ADJ
admet-2626	266	10	glibenclamide	glibenclamide	NOUN
admet-2626	266	11	is	be	AUX
admet-2626	266	12	below	below	ADP
admet-2626	266	13	its	its	PRON
admet-2626	266	14	pka	pka	NOUN
admet-2626	266	15	by	by	ADP
admet-2626	266	16	0.43	0.43	NUM
admet-2626	266	17	log	log	NOUN
admet-2626	266	18	unit	unit	NOUN
admet-2626	266	19	.	.	PUNCT
admet-2626	267	1	in	in	ADP
admet-2626	267	2	figure	figure	NOUN
admet-2626	267	3	1c	1c	NOUN
admet-2626	267	4	,	,	PUNCT
admet-2626	267	5	the	the	DET
admet-2626	267	6	solid	solid	ADJ
admet-2626	267	7	curve	curve	NOUN
admet-2626	267	8	has	have	VERB
admet-2626	267	9	a	a	DET
admet-2626	267	10	‘	'	PUNCT
admet-2626	267	11	rotated	rotated	ADJ
admet-2626	267	12	sigmoidal	sigmoidal	NOUN
admet-2626	267	13	’	'	PUNCT
admet-2626	267	14	distortion	distortion	NOUN
admet-2626	267	15	,	,	PUNCT
admet-2626	267	16	compared	compare	VERB
admet-2626	267	17	to	to	ADP
admet-2626	267	18	the	the	DET
admet-2626	267	19	benchmark	benchmark	NOUN
admet-2626	267	20	hh	hh	PROPN
admet-2626	267	21	hyperbolic	hyperbolic	NOUN
admet-2626	267	22	(	(	PUNCT
admet-2626	267	23	dashed	dash	VERB
admet-2626	267	24	)	)	PUNCT
admet-2626	267	25	curve	curve	NOUN
admet-2626	267	26	.	.	PUNCT
admet-2626	268	1	the	the	DET
admet-2626	268	2	solubility	solubility	NOUN
admet-2626	268	3	difference	difference	NOUN
admet-2626	268	4	between	between	ADP
admet-2626	268	5	the	the	DET
admet-2626	268	6	two	two	NUM
admet-2626	268	7	curves	curve	NOUN
admet-2626	268	8	maximizes	maximize	NOUN
admet-2626	268	9	at	at	ADP
admet-2626	268	10	phw	phw	NOUN
admet-2626	268	11	(	(	PUNCT
admet-2626	268	12	where	where	SCONJ
admet-2626	268	13	i	i	PRON
admet-2626	268	14	and	and	CCONJ
admet-2626	268	15	iref	iref	NOUN
admet-2626	268	16	are	be	AUX
admet-2626	268	17	most	most	ADV
admet-2626	268	18	different	different	ADJ
admet-2626	268	19	)	)	PUNCT
admet-2626	268	20	.	.	PUNCT
admet-2626	269	1	the	the	DET
admet-2626	269	2	solid	solid	ADJ
admet-2626	269	3	and	and	CCONJ
admet-2626	269	4	dashed	dash	VERB
admet-2626	269	5	curves	curve	NOUN
admet-2626	269	6	cross	cross	NOUN
admet-2626	269	7	at	at	ADP
admet-2626	269	8	ph	ph	NOUN
admet-2626	269	9	near	near	ADP
admet-2626	269	10	0.9	0.9	NUM
admet-2626	269	11	and	and	CCONJ
admet-2626	269	12	8.5	8.5	NUM
admet-2626	269	13	,	,	PUNCT
admet-2626	269	14	as	as	SCONJ
admet-2626	269	15	the	the	DET
admet-2626	269	16	ionic	ionic	ADJ
admet-2626	269	17	strengths	strength	NOUN
admet-2626	269	18	become	become	VERB
admet-2626	269	19	equal	equal	ADJ
admet-2626	269	20	at	at	ADP
admet-2626	269	21	those	those	DET
admet-2626	269	22	points	point	NOUN
admet-2626	269	23	.	.	PUNCT
admet-2626	270	1	figure	figure	NOUN
admet-2626	270	2	1	1	NUM
admet-2626	270	3	.	.	PUNCT
admet-2626	271	1	profiles	profile	NOUN
admet-2626	271	2	of	of	ADP
admet-2626	271	3	log	log	NOUN
admet-2626	271	4	s	s	NOUN
admet-2626	271	5	-	-	PUNCT
admet-2626	271	6	ph	ph	ADJ
admet-2626	271	7	generated	generate	VERB
admet-2626	271	8	by	by	ADP
admet-2626	271	9	analytic	analytic	ADJ
admet-2626	271	10	continuation	continuation	NOUN
admet-2626	271	11	for	for	ADP
admet-2626	271	12	three	three	NUM
admet-2626	271	13	weak	weak	ADJ
admet-2626	271	14	acids	acid	NOUN
admet-2626	271	15	,	,	PUNCT
admet-2626	271	16	(	(	PUNCT
admet-2626	271	17	a	a	X
admet-2626	271	18	)	)	PUNCT
admet-2626	271	19	crocetin	crocetin	NOUN
admet-2626	271	20	[	[	X
admet-2626	271	21	18	18	NUM
admet-2626	271	22	]	]	PUNCT
admet-2626	271	23	,	,	PUNCT
admet-2626	271	24	(	(	PUNCT
admet-2626	271	25	b	b	NOUN
admet-2626	271	26	)	)	PUNCT
admet-2626	271	27	glibenclamide	glibenclamide	NOUN
admet-2626	271	28	[	[	X
admet-2626	271	29	17	17	NUM
admet-2626	271	30	]	]	PUNCT
admet-2626	271	31	,	,	PUNCT
admet-2626	271	32	and	and	CCONJ
admet-2626	271	33	(	(	PUNCT
admet-2626	271	34	c	c	NOUN
admet-2626	271	35	)	)	PUNCT
admet-2626	271	36	acetaminophen	acetaminophen	NOUN
admet-2626	272	1	[	[	X
admet-2626	272	2	17	17	NUM
admet-2626	272	3	]	]	PUNCT
admet-2626	272	4	.	.	PUNCT
admet-2626	273	1	the	the	DET
admet-2626	273	2	solubility	solubility	NOUN
admet-2626	273	3	-	-	PUNCT
admet-2626	273	4	ph	ph	ADJ
admet-2626	273	5	curves	curve	NOUN
admet-2626	273	6	(	(	PUNCT
admet-2626	273	7	solid	solid	ADJ
admet-2626	273	8	green	green	NOUN
admet-2626	273	9	)	)	PUNCT
admet-2626	273	10	were	be	AUX
admet-2626	273	11	generated	generate	VERB
admet-2626	273	12	by	by	ADP
admet-2626	273	13	simulations	simulation	NOUN
admet-2626	273	14	started	start	VERB
admet-2626	273	15	at	at	ADP
admet-2626	273	16	phw	phw	NOUN
admet-2626	273	17	with	with	ADP
admet-2626	273	18	ph	ph	PROPN
admet-2626	273	19	adjusted	adjust	VERB
admet-2626	273	20	downwards	downward	NOUN
admet-2626	273	21	using	use	VERB
admet-2626	273	22	hcl	hcl	PROPN
admet-2626	273	23	titrant	titrant	NOUN
admet-2626	273	24	and	and	CCONJ
admet-2626	273	25	upwards	upwards	ADV
admet-2626	273	26	using	use	VERB
admet-2626	273	27	naoh	naoh	NOUN
admet-2626	273	28	.	.	PUNCT
admet-2626	274	1	the	the	DET
admet-2626	274	2	dashed	dash	VERB
admet-2626	274	3	curves	curve	NOUN
admet-2626	274	4	were	be	AUX
admet-2626	274	5	calculated	calculate	VERB
admet-2626	274	6	using	use	VERB
admet-2626	274	7	the	the	DET
admet-2626	274	8	hh	hh	PROPN
admet-2626	274	9	equation	equation	NOUN
admet-2626	274	10	,	,	PUNCT
admet-2626	274	11	incorporating	incorporate	VERB
admet-2626	274	12	pka	pka	PROPN
admet-2626	274	13	ref	ref	NOUN
admet-2626	274	14	and	and	CCONJ
admet-2626	274	15	log	log	VERB
admet-2626	274	16	s0	s0	PROPN
admet-2626	274	17	ref	ref	NOUN
admet-2626	274	18	values	value	NOUN
admet-2626	274	19	,	,	PUNCT
admet-2626	274	20	at	at	ADP
admet-2626	274	21	iref	iref	NOUN
admet-2626	274	22	=	=	PUNCT
admet-2626	274	23	0.15	0.15	NUM
admet-2626	274	24	m	m	VERB
admet-2626	274	25	(	(	PUNCT
admet-2626	274	26	without	without	ADP
admet-2626	274	27	activity	activity	NOUN
admet-2626	274	28	corrections	correction	NOUN
admet-2626	274	29	)	)	PUNCT
admet-2626	274	30	figure	figure	NOUN
admet-2626	274	31	2	2	NUM
admet-2626	274	32	shows	show	NOUN
admet-2626	274	33	log	log	VERB
admet-2626	274	34	s	s	ADJ
admet-2626	274	35	-	-	PUNCT
admet-2626	274	36	ph	ph	ADJ
admet-2626	274	37	plots	plot	NOUN
admet-2626	274	38	for	for	ADP
admet-2626	274	39	the	the	DET
admet-2626	274	40	benzene	benzene	NOUN
admet-2626	274	41	polycarboxylic	polycarboxylic	ADJ
admet-2626	274	42	acid	acid	NOUN
admet-2626	274	43	series	series	NOUN
admet-2626	274	44	.	.	PUNCT
admet-2626	275	1	for	for	ADP
admet-2626	275	2	benzoic	benzoic	ADJ
admet-2626	275	3	,	,	PUNCT
admet-2626	275	4	phthalic	phthalic	ADJ
admet-2626	275	5	,	,	PUNCT
admet-2626	275	6	trimellitic	trimellitic	ADJ
admet-2626	275	7	,	,	PUNCT
admet-2626	275	8	and	and	CCONJ
admet-2626	275	9	pyromellitic	pyromellitic	ADJ
admet-2626	275	10	acids	acid	NOUN
admet-2626	275	11	,	,	PUNCT
admet-2626	275	12	the	the	DET
admet-2626	275	13	hyperbolic	hyperbolic	ADJ
admet-2626	275	14	profiles	profile	NOUN
admet-2626	275	15	take	take	VERB
admet-2626	275	16	on	on	ADP
admet-2626	275	17	typical	typical	ADJ
admet-2626	275	18	activity	activity	NOUN
admet-2626	275	19	-	-	PUNCT
admet-2626	275	20	distorted	distort	VERB
admet-2626	275	21	shapes	shape	NOUN
admet-2626	275	22	.	.	PUNCT
admet-2626	276	1	as	as	ADP
admet-2626	276	2	the	the	DET
admet-2626	276	3	number	number	NOUN
admet-2626	276	4	of	of	ADP
admet-2626	276	5	carboxylic	carboxylic	ADJ
admet-2626	276	6	groups	group	NOUN
admet-2626	276	7	(	(	PUNCT
admet-2626	276	8	with	with	ADP
admet-2626	276	9	overlapping	overlap	VERB
admet-2626	276	10	pka	pka	PROPN
admet-2626	276	11	)	)	PUNCT
admet-2626	276	12	increases	increase	NOUN
admet-2626	276	13	,	,	PUNCT
admet-2626	276	14	so	so	ADV
admet-2626	276	15	does	do	VERB
admet-2626	276	16	the	the	DET
admet-2626	276	17	solubility	solubility	NOUN
admet-2626	276	18	,	,	PUNCT
admet-2626	276	19	with	with	ADP
admet-2626	276	20	mellitic	mellitic	ADJ
admet-2626	276	21	acid	acid	NOUN
admet-2626	276	22	reaching	reach	VERB
admet-2626	276	23	the	the	DET
admet-2626	276	24	high	high	ADJ
admet-2626	276	25	value	value	NOUN
admet-2626	276	26	of	of	ADP
admet-2626	276	27	988	988	NUM
admet-2626	276	28	mg	mg	NOUN
admet-2626	276	29	/	/	SYM
admet-2626	276	30	ml	ml	PROPN
admet-2626	276	31	(	(	PUNCT
admet-2626	276	32	table	table	NOUN
admet-2626	276	33	2	2	NUM
admet-2626	276	34	)	)	PUNCT
admet-2626	276	35	.	.	PUNCT
admet-2626	277	1	due	due	ADP
admet-2626	277	2	to	to	ADP
admet-2626	277	3	the	the	DET
admet-2626	277	4	increasing	increase	VERB
admet-2626	277	5	ionic	ionic	ADJ
admet-2626	277	6	strength	strength	NOUN
admet-2626	277	7	with	with	ADP
admet-2626	277	8	solubility	solubility	NOUN
admet-2626	277	9	,	,	PUNCT
admet-2626	277	10	especially	especially	ADV
admet-2626	277	11	as	as	SCONJ
admet-2626	277	12	the	the	DET
admet-2626	277	13	charges	charge	NOUN
admet-2626	277	14	increase	increase	VERB
admet-2626	277	15	on	on	ADP
admet-2626	277	16	the	the	DET
admet-2626	277	17	polycarboxylates	polycarboxylate	NOUN
admet-2626	277	18	as	as	ADP
admet-2626	277	19	ph	ph	ADJ
admet-2626	277	20	increases	increase	NOUN
admet-2626	277	21	,	,	PUNCT
admet-2626	277	22	the	the	DET
admet-2626	277	23	distortions	distortion	NOUN
admet-2626	277	24	from	from	ADP
admet-2626	277	25	the	the	DET
admet-2626	277	26	henderson	henderson	PROPN
admet-2626	277	27	-	-	PUNCT
admet-2626	277	28	hasselbalch	hasselbalch	PROPN
admet-2626	277	29	benchmarks	benchmark	NOUN
admet-2626	277	30	(	(	PUNCT
admet-2626	277	31	dashed	dash	VERB
admet-2626	277	32	curves	curve	NOUN
admet-2626	277	33	in	in	ADP
admet-2626	277	34	fig	fig	NOUN
admet-2626	277	35	.	.	PUNCT
admet-2626	278	1	2	2	X
admet-2626	278	2	)	)	PUNCT
admet-2626	278	3	become	become	VERB
admet-2626	278	4	most	most	ADV
admet-2626	278	5	pronounced	pronounce	VERB
admet-2626	278	6	.	.	PUNCT
admet-2626	279	1	as	as	ADP
admet-2626	279	2	ph	ph	ADJ
admet-2626	279	3	increases	increase	NOUN
admet-2626	279	4	,	,	PUNCT
admet-2626	279	5	the	the	DET
admet-2626	279	6	increasing	increase	VERB
admet-2626	279	7	ionic	ionic	ADJ
admet-2626	279	8	strength	strength	NOUN
admet-2626	279	9	exceeds	exceed	VERB
admet-2626	279	10	7	7	NUM
admet-2626	279	11	m	m	NOUN
admet-2626	279	12	past	past	ADJ
admet-2626	279	13	ph	ph	ADJ
admet-2626	279	14	2.3	2.3	NUM
admet-2626	279	15	,	,	PUNCT
admet-2626	279	16	3.7	3.7	NUM
admet-2626	279	17	,	,	PUNCT
admet-2626	279	18	4.1	4.1	NUM
admet-2626	279	19	,	,	PUNCT
admet-2626	279	20	and	and	CCONJ
admet-2626	279	21	7.0	7.0	NUM
admet-2626	279	22	for	for	ADP
admet-2626	279	23	mellitic	mellitic	ADJ
admet-2626	279	24	,	,	PUNCT
admet-2626	279	25	benzene	benzene	ADJ
admet-2626	279	26	pentacarboxylic	pentacarboxylic	NOUN
admet-2626	279	27	,	,	PUNCT
admet-2626	279	28	mellophanic	mellophanic	ADJ
admet-2626	279	29	,	,	PUNCT
admet-2626	279	30	and	and	CCONJ
admet-2626	279	31	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	279	32	a.	a.	NOUN
admet-2626	279	33	avdeef	avdeef	PROPN
admet-2626	279	34	admet	admet	PROPN
admet-2626	279	35	&	&	CCONJ
admet-2626	279	36	dmpk	dmpk	PROPN
admet-2626	279	37	13(1	13(1	NUM
admet-2626	279	38	)	)	PUNCT
admet-2626	279	39	(	(	PUNCT
admet-2626	279	40	2025	2025	NUM
admet-2626	279	41	)	)	PUNCT
admet-2626	280	1	2626	2626	NUM
admet-2626	280	2	10	10	NUM
admet-2626	280	3	hemimellitic	hemimellitic	ADJ
admet-2626	280	4	acids	acid	NOUN
admet-2626	280	5	,	,	PUNCT
admet-2626	280	6	respectively	respectively	ADV
admet-2626	280	7	.	.	PUNCT
admet-2626	281	1	the	the	DET
admet-2626	281	2	other	other	ADJ
admet-2626	281	3	four	four	NUM
admet-2626	281	4	(	(	PUNCT
admet-2626	281	5	mostly	mostly	ADV
admet-2626	281	6	less	less	ADV
admet-2626	281	7	soluble	soluble	ADJ
admet-2626	281	8	)	)	PUNCT
admet-2626	281	9	carboxylic	carboxylic	ADJ
admet-2626	281	10	acids	acid	NOUN
admet-2626	281	11	have	have	VERB
admet-2626	281	12	ionic	ionic	ADJ
admet-2626	281	13	strengths	strength	NOUN
admet-2626	281	14	that	that	PRON
admet-2626	281	15	level	level	VERB
admet-2626	281	16	off	off	ADP
admet-2626	281	17	at	at	ADP
admet-2626	281	18	ph	ph	PROPN
admet-2626	281	19	7.4	7.4	NUM
admet-2626	281	20	at	at	ADP
admet-2626	281	21	i	i	PROPN
admet-2626	281	22	=	=	NOUN
admet-2626	281	23	4.5	4.5	NUM
admet-2626	281	24	(	(	PUNCT
admet-2626	281	25	trimellitic	trimellitic	PROPN
admet-2626	281	26	)	)	PUNCT
admet-2626	281	27	,	,	PUNCT
admet-2626	281	28	3.6	3.6	NUM
admet-2626	281	29	(	(	PUNCT
admet-2626	281	30	pyromellitic	pyromellitic	NOUN
admet-2626	281	31	)	)	PUNCT
admet-2626	281	32	,	,	PUNCT
admet-2626	281	33	1.2	1.2	NUM
admet-2626	281	34	(	(	PUNCT
admet-2626	281	35	phthalic	phthalic	ADJ
admet-2626	281	36	)	)	PUNCT
admet-2626	281	37	,	,	PUNCT
admet-2626	281	38	and	and	CCONJ
admet-2626	281	39	0.3	0.3	NUM
admet-2626	281	40	m	m	NOUN
admet-2626	281	41	(	(	PUNCT
admet-2626	281	42	benzoic	benzoic	NOUN
admet-2626	281	43	)	)	PUNCT
admet-2626	281	44	.	.	PUNCT
admet-2626	282	1	the	the	DET
admet-2626	282	2	extreme	extreme	ADJ
admet-2626	282	3	distortions	distortion	NOUN
admet-2626	282	4	in	in	ADP
admet-2626	282	5	figure	figure	NOUN
admet-2626	282	6	2	2	NUM
admet-2626	282	7	related	relate	VERB
admet-2626	282	8	to	to	ADP
admet-2626	282	9	activity	activity	NOUN
admet-2626	282	10	corrections	correction	NOUN
admet-2626	282	11	appear	appear	VERB
admet-2626	282	12	not	not	PART
admet-2626	282	13	to	to	PART
admet-2626	282	14	have	have	AUX
admet-2626	282	15	been	be	AUX
admet-2626	282	16	previously	previously	ADV
admet-2626	282	17	reported	report	VERB
admet-2626	282	18	.	.	PUNCT
admet-2626	283	1	in	in	ADP
admet-2626	283	2	the	the	DET
admet-2626	283	3	case	case	NOUN
admet-2626	283	4	of	of	ADP
admet-2626	283	5	mellitic	mellitic	ADJ
admet-2626	283	6	acid	acid	NOUN
admet-2626	283	7	,	,	PUNCT
admet-2626	283	8	iw	iw	PROPN
admet-2626	283	9	exceed	exceed	VERB
admet-2626	283	10	iref	iref	NOUN
admet-2626	283	11	,	,	PUNCT
admet-2626	283	12	and	and	CCONJ
admet-2626	283	13	depends	depend	VERB
admet-2626	283	14	on	on	ADP
admet-2626	283	15	the	the	DET
admet-2626	283	16	excess	excess	ADJ
admet-2626	283	17	quantity	quantity	NOUN
admet-2626	283	18	of	of	ADP
admet-2626	283	19	neutral	neutral	ADJ
admet-2626	283	20	acid	acid	NOUN
admet-2626	283	21	solid	solid	NOUN
admet-2626	283	22	added	add	VERB
admet-2626	283	23	to	to	ADP
admet-2626	283	24	distilled	distil	VERB
admet-2626	283	25	water	water	NOUN
admet-2626	283	26	(	(	PUNCT
admet-2626	283	27	cf	cf	NOUN
admet-2626	283	28	.	.	PUNCT
admet-2626	283	29	table	table	NOUN
admet-2626	283	30	1	1	NUM
admet-2626	283	31	)	)	PUNCT
admet-2626	283	32	.	.	PUNCT
admet-2626	284	1	this	this	DET
admet-2626	284	2	concentration	concentration	NOUN
admet-2626	284	3	dependence	dependence	NOUN
admet-2626	284	4	is	be	AUX
admet-2626	284	5	also	also	ADV
admet-2626	284	6	evident	evident	ADJ
admet-2626	284	7	in	in	ADP
admet-2626	284	8	the	the	DET
admet-2626	284	9	case	case	NOUN
admet-2626	284	10	for	for	ADP
admet-2626	284	11	l	l	NOUN
admet-2626	284	12	-	-	NOUN
admet-2626	284	13	lysine	lysine	NOUN
admet-2626	284	14	.	.	PUNCT
admet-2626	285	1	from	from	ADP
admet-2626	285	2	the	the	DET
admet-2626	285	3	perspective	perspective	NOUN
admet-2626	285	4	of	of	ADP
admet-2626	285	5	solubility	solubility	NOUN
admet-2626	285	6	measurement	measurement	NOUN
admet-2626	285	7	,	,	PUNCT
admet-2626	285	8	when	when	SCONJ
admet-2626	285	9	iw	iw	PRON
admet-2626	285	10	exceeds	exceed	NOUN
admet-2626	285	11	iref	iref	NOUN
admet-2626	285	12	,	,	PUNCT
admet-2626	285	13	it	it	PRON
admet-2626	285	14	may	may	AUX
admet-2626	285	15	be	be	AUX
admet-2626	285	16	of	of	ADP
admet-2626	285	17	limited	limited	ADJ
admet-2626	285	18	use	use	NOUN
admet-2626	285	19	to	to	PART
admet-2626	285	20	adjust	adjust	VERB
admet-2626	285	21	the	the	DET
admet-2626	285	22	water	water	NOUN
admet-2626	285	23	solubility	solubility	NOUN
admet-2626	285	24	observed	observe	VERB
admet-2626	285	25	at	at	ADP
admet-2626	285	26	iw	iw	PRON
admet-2626	285	27	to	to	ADP
admet-2626	285	28	the	the	DET
admet-2626	285	29	expected	expect	VERB
admet-2626	285	30	value	value	NOUN
admet-2626	285	31	at	at	ADP
admet-2626	285	32	the	the	DET
admet-2626	285	33	physiologically	physiologically	ADV
admet-2626	285	34	relevant	relevant	ADJ
admet-2626	285	35	iref	iref	NOUN
admet-2626	285	36	,	,	PUNCT
admet-2626	285	37	since	since	SCONJ
admet-2626	285	38	at	at	ADP
admet-2626	285	39	that	that	DET
admet-2626	285	40	reference	reference	NOUN
admet-2626	285	41	ionic	ionic	ADJ
admet-2626	285	42	strength	strength	NOUN
admet-2626	285	43	,	,	PUNCT
admet-2626	285	44	both	both	CCONJ
admet-2626	285	45	mellitic	mellitic	ADJ
admet-2626	285	46	acid	acid	NOUN
admet-2626	285	47	and	and	CCONJ
admet-2626	285	48	l	l	NOUN
admet-2626	285	49	-	-	NOUN
admet-2626	285	50	lysine	lysine	NOUN
admet-2626	285	51	are	be	AUX
admet-2626	285	52	apt	apt	ADJ
admet-2626	285	53	to	to	PART
admet-2626	285	54	dissolve	dissolve	VERB
admet-2626	285	55	completely	completely	ADV
admet-2626	285	56	at	at	ADP
admet-2626	285	57	practical	practical	ADJ
admet-2626	285	58	concentrations	concentration	NOUN
admet-2626	285	59	.	.	PUNCT
admet-2626	286	1	figure	figure	NOUN
admet-2626	286	2	2	2	NUM
admet-2626	286	3	.	.	PUNCT
admet-2626	286	4	calculated	calculate	VERB
admet-2626	286	5	log	log	PROPN
admet-2626	286	6	s	s	NOUN
admet-2626	286	7	-	-	PUNCT
admet-2626	286	8	ph	ph	ADJ
admet-2626	286	9	profiles	profile	NOUN
admet-2626	286	10	of	of	ADP
admet-2626	286	11	the	the	DET
admet-2626	286	12	benzene	benzene	NOUN
admet-2626	286	13	polycarboxylic	polycarboxylic	ADJ
admet-2626	286	14	acid	acid	NOUN
admet-2626	286	15	series	series	NOUN
admet-2626	286	16	[	[	X
admet-2626	286	17	16	16	NUM
admet-2626	286	18	]	]	PUNCT
admet-2626	286	19	.	.	PUNCT
admet-2626	287	1	the	the	DET
admet-2626	287	2	solubility	solubility	NOUN
admet-2626	287	3	-	-	PUNCT
admet-2626	287	4	ph	ph	ADJ
admet-2626	287	5	curves	curve	NOUN
admet-2626	287	6	(	(	PUNCT
admet-2626	287	7	solid	solid	ADJ
admet-2626	287	8	green	green	NOUN
admet-2626	287	9	)	)	PUNCT
admet-2626	287	10	were	be	AUX
admet-2626	287	11	generated	generate	VERB
admet-2626	287	12	with	with	ADP
admet-2626	287	13	simulations	simulation	NOUN
admet-2626	287	14	started	start	VERB
admet-2626	287	15	at	at	ADP
admet-2626	287	16	phw	phw	NOUN
admet-2626	287	17	with	with	ADP
admet-2626	287	18	ph	ph	PROPN
admet-2626	287	19	adjusted	adjust	VERB
admet-2626	287	20	downwards	downward	NOUN
admet-2626	287	21	using	use	VERB
admet-2626	287	22	hcl	hcl	PROPN
admet-2626	287	23	titrant	titrant	NOUN
admet-2626	287	24	and	and	CCONJ
admet-2626	287	25	upwards	upwards	ADV
admet-2626	287	26	using	use	VERB
admet-2626	287	27	naoh	naoh	NOUN
admet-2626	287	28	.	.	PUNCT
admet-2626	288	1	the	the	DET
admet-2626	288	2	dashed	dash	VERB
admet-2626	288	3	curves	curve	NOUN
admet-2626	288	4	were	be	AUX
admet-2626	288	5	calculated	calculate	VERB
admet-2626	288	6	using	use	VERB
admet-2626	288	7	the	the	DET
admet-2626	288	8	hh	hh	PROPN
admet-2626	288	9	equation	equation	NOUN
admet-2626	288	10	,	,	PUNCT
admet-2626	288	11	incorporating	incorporate	VERB
admet-2626	288	12	pka	pka	PROPN
admet-2626	288	13	ref	ref	NOUN
admet-2626	288	14	and	and	CCONJ
admet-2626	288	15	log	log	VERB
admet-2626	288	16	s0	s0	PROPN
admet-2626	288	17	ref	ref	NOUN
admet-2626	288	18	values	value	NOUN
admet-2626	288	19	,	,	PUNCT
admet-2626	288	20	at	at	ADP
admet-2626	288	21	iref	iref	NOUN
admet-2626	288	22	=	=	PUNCT
admet-2626	288	23	0.15	0.15	NUM
admet-2626	288	24	m	m	VERB
admet-2626	288	25	(	(	PUNCT
admet-2626	288	26	without	without	ADP
admet-2626	288	27	corrections	correction	NOUN
admet-2626	288	28	for	for	ADP
admet-2626	288	29	activity	activity	NOUN
admet-2626	288	30	effects	effect	NOUN
admet-2626	288	31	)	)	PUNCT
admet-2626	288	32	figure	figure	NOUN
admet-2626	288	33	3	3	NUM
admet-2626	288	34	illustrates	illustrate	VERB
admet-2626	288	35	the	the	DET
admet-2626	288	36	log	log	NOUN
admet-2626	288	37	s	s	NOUN
admet-2626	288	38	-	-	PUNCT
admet-2626	288	39	ph	ph	ADJ
admet-2626	288	40	relationships	relationship	NOUN
admet-2626	288	41	of	of	ADP
admet-2626	288	42	three	three	NUM
admet-2626	288	43	selected	select	VERB
admet-2626	288	44	bases	basis	NOUN
admet-2626	288	45	(	(	PUNCT
admet-2626	288	46	arranged	arrange	VERB
admet-2626	288	47	in	in	ADP
admet-2626	288	48	increasing	increase	VERB
admet-2626	288	49	order	order	NOUN
admet-2626	288	50	of	of	ADP
admet-2626	288	51	intrinsic	intrinsic	ADJ
admet-2626	288	52	solubility	solubility	NOUN
admet-2626	288	53	)	)	PUNCT
admet-2626	288	54	.	.	PUNCT
admet-2626	289	1	the	the	DET
admet-2626	289	2	ionic	ionic	ADJ
admet-2626	289	3	strength	strength	NOUN
admet-2626	289	4	values	value	NOUN
admet-2626	289	5	are	be	AUX
admet-2626	289	6	at	at	ADP
admet-2626	289	7	their	their	PRON
admet-2626	289	8	minimum	minimum	NOUN
admet-2626	289	9	at	at	ADP
admet-2626	289	10	phw	phw	NOUN
admet-2626	289	11	.	.	PUNCT
admet-2626	290	1	as	as	SCONJ
admet-2626	290	2	ph	ph	NOUN
admet-2626	290	3	is	be	AUX
admet-2626	290	4	adjusted	adjust	VERB
admet-2626	290	5	by	by	ADP
admet-2626	290	6	additions	addition	NOUN
admet-2626	290	7	of	of	ADP
admet-2626	290	8	hcl	hcl	PROPN
admet-2626	290	9	/	/	SYM
admet-2626	290	10	naoh	naoh	NOUN
admet-2626	290	11	in	in	ADP
admet-2626	290	12	the	the	DET
admet-2626	290	13	simulated	simulate	VERB
admet-2626	290	14	analytic	analytic	ADJ
admet-2626	290	15	continuation	continuation	NOUN
admet-2626	290	16	procedure	procedure	NOUN
admet-2626	290	17	,	,	PUNCT
admet-2626	290	18	the	the	DET
admet-2626	290	19	ionic	ionic	ADJ
admet-2626	290	20	strength	strength	NOUN
admet-2626	290	21	increases	increase	NOUN
admet-2626	290	22	,	,	PUNCT
admet-2626	290	23	just	just	ADV
admet-2626	290	24	as	as	ADP
admet-2626	290	25	in	in	ADP
admet-2626	290	26	the	the	DET
admet-2626	290	27	cases	case	NOUN
admet-2626	290	28	of	of	ADP
admet-2626	290	29	simple	simple	ADJ
admet-2626	290	30	weak	weak	ADJ
admet-2626	290	31	acids	acid	NOUN
admet-2626	290	32	.	.	PUNCT
admet-2626	291	1	the	the	DET
admet-2626	291	2	characteristic	characteristic	ADJ
admet-2626	291	3	distortions	distortion	NOUN
admet-2626	291	4	of	of	ADP
admet-2626	291	5	the	the	DET
admet-2626	291	6	solid	solid	ADJ
admet-2626	291	7	(	(	PUNCT
admet-2626	291	8	green	green	ADJ
admet-2626	291	9	)	)	PUNCT
admet-2626	291	10	curves	curve	NOUN
admet-2626	291	11	are	be	AUX
admet-2626	291	12	the	the	DET
admet-2626	291	13	consequence	consequence	NOUN
admet-2626	291	14	of	of	ADP
admet-2626	291	15	activity	activity	NOUN
admet-2626	291	16	corrections	correction	NOUN
admet-2626	291	17	,	,	PUNCT
admet-2626	291	18	which	which	PRON
admet-2626	291	19	depend	depend	VERB
admet-2626	291	20	on	on	ADP
admet-2626	291	21	the	the	DET
admet-2626	291	22	differences	difference	NOUN
admet-2626	291	23	,	,	PUNCT
admet-2626	291	24	i	i	PRON
admet-2626	291	25	iref	iref	VERB
admet-2626	291	26	.	.	PUNCT
admet-2626	292	1	a	a	DET
admet-2626	292	2	partial	partial	ADJ
admet-2626	292	3	‘	'	PUNCT
admet-2626	292	4	rotated	rotate	VERB
admet-2626	292	5	sigmoidal	sigmoidal	NOUN
admet-2626	292	6	’	'	PUNCT
admet-2626	292	7	shape	shape	NOUN
admet-2626	292	8	distortion	distortion	NOUN
admet-2626	292	9	is	be	AUX
admet-2626	292	10	evident	evident	ADJ
admet-2626	292	11	for	for	ADP
admet-2626	292	12	bedaquiline	bedaquiline	NOUN
admet-2626	292	13	and	and	CCONJ
admet-2626	292	14	brigatinib	brigatinib	NOUN
admet-2626	292	15	,	,	PUNCT
admet-2626	292	16	compared	compare	VERB
admet-2626	292	17	to	to	ADP
admet-2626	292	18	the	the	DET
admet-2626	292	19	hh	hh	PROPN
admet-2626	292	20	hyperbolic	hyperbolic	PROPN
admet-2626	292	21	dashed	dash	VERB
admet-2626	292	22	curve	curve	NOUN
admet-2626	292	23	at	at	ADP
admet-2626	292	24	iref	iref	NOUN
admet-2626	292	25	=	=	PUNCT
admet-2626	292	26	0.15	0.15	NUM
admet-2626	292	27	m.	m.	NOUN
admet-2626	292	28	the	the	DET
admet-2626	292	29	position	position	NOUN
admet-2626	292	30	of	of	ADP
admet-2626	292	31	phw	phw	NOUN
admet-2626	292	32	in	in	ADP
admet-2626	292	33	relation	relation	NOUN
admet-2626	292	34	to	to	ADP
admet-2626	292	35	the	the	DET
admet-2626	292	36	pka	pka	PROPN
admet-2626	292	37	mirrors	mirror	NOUN
admet-2626	292	38	the	the	DET
admet-2626	292	39	trends	trend	NOUN
admet-2626	292	40	illustrated	illustrate	VERB
admet-2626	292	41	in	in	ADP
admet-2626	292	42	figure	figure	NOUN
admet-2626	292	43	1	1	NUM
admet-2626	292	44	and	and	CCONJ
admet-2626	292	45	can	can	AUX
admet-2626	292	46	be	be	AUX
admet-2626	292	47	explained	explain	VERB
admet-2626	292	48	by	by	ADP
admet-2626	292	49	the	the	DET
admet-2626	292	50	effects	effect	NOUN
admet-2626	292	51	of	of	ADP
admet-2626	292	52	solubility	solubility	NOUN
admet-2626	292	53	and	and	CCONJ
admet-2626	292	54	how	how	SCONJ
admet-2626	292	55	far	far	ADV
admet-2626	292	56	the	the	DET
admet-2626	292	57	pka	pka	PROPN
admet-2626	292	58	values	value	NOUN
admet-2626	292	59	are	be	AUX
admet-2626	292	60	from	from	ADP
admet-2626	292	61	ph	ph	ADJ
admet-2626	292	62	7	7	ADJ
admet-2626	292	63	of	of	ADP
admet-2626	292	64	pure	pure	ADJ
admet-2626	292	65	water	water	NOUN
admet-2626	292	66	.	.	PUNCT
admet-2626	293	1	the	the	DET
admet-2626	293	2	less	less	ADV
admet-2626	293	3	soluble	soluble	ADJ
admet-2626	293	4	the	the	DET
admet-2626	293	5	base	base	NOUN
admet-2626	293	6	,	,	PUNCT
admet-2626	293	7	the	the	DET
admet-2626	293	8	more	more	ADJ
admet-2626	293	9	is	be	AUX
admet-2626	293	10	the	the	DET
admet-2626	293	11	phw	phw	NOUN
admet-2626	293	12	apt	apt	ADJ
admet-2626	293	13	to	to	PART
admet-2626	293	14	be	be	AUX
admet-2626	293	15	in	in	ADP
admet-2626	293	16	the	the	DET
admet-2626	293	17	diagonal	diagonal	ADJ
admet-2626	293	18	region	region	NOUN
admet-2626	293	19	of	of	ADP
admet-2626	293	20	the	the	DET
admet-2626	293	21	log	log	NOUN
admet-2626	293	22	s	s	NOUN
admet-2626	293	23	-	-	PUNCT
admet-2626	293	24	ph	ph	ADJ
admet-2626	293	25	profile	profile	NOUN
admet-2626	293	26	.	.	PUNCT
admet-2626	294	1	admet	admet	PROPN
admet-2626	294	2	&	&	CCONJ
admet-2626	294	3	dmpk	dmpk	PROPN
admet-2626	294	4	13(1	13(1	NUM
admet-2626	294	5	)	)	PUNCT
admet-2626	294	6	(	(	PUNCT
admet-2626	294	7	2025	2025	NUM
admet-2626	294	8	)	)	PUNCT
admet-2626	294	9	2626	2626	NUM
admet-2626	294	10	transforming	transform	VERB
admet-2626	294	11	drug	drug	NOUN
admet-2626	294	12	solubility	solubility	NOUN
admet-2626	294	13	measurement	measurement	NOUN
admet-2626	294	14	doi	doi	PROPN
admet-2626	294	15	:	:	PUNCT
admet-2626	294	16	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	294	17	11	11	NUM
admet-2626	294	18	figure	figure	NOUN
admet-2626	294	19	3	3	NUM
admet-2626	294	20	.	.	PUNCT
admet-2626	294	21	simulated	simulate	VERB
admet-2626	294	22	log	log	PROPN
admet-2626	294	23	s	s	NOUN
admet-2626	294	24	-	-	PUNCT
admet-2626	294	25	ph	ph	ADJ
admet-2626	294	26	profiles	profile	NOUN
admet-2626	294	27	of	of	ADP
admet-2626	294	28	three	three	NUM
admet-2626	294	29	weak	weak	ADJ
admet-2626	294	30	based	base	VERB
admet-2626	294	31	:	:	PUNCT
admet-2626	294	32	(	(	PUNCT
admet-2626	294	33	a	a	X
admet-2626	294	34	)	)	PUNCT
admet-2626	294	35	bedaquiline	bedaquiline	NOUN
admet-2626	294	36	[	[	X
admet-2626	294	37	21	21	NUM
admet-2626	294	38	]	]	PUNCT
admet-2626	294	39	,	,	PUNCT
admet-2626	294	40	(	(	PUNCT
admet-2626	294	41	b	b	X
admet-2626	294	42	)	)	PUNCT
admet-2626	294	43	imatinib	imatinib	NOUN
admet-2626	294	44	[	[	X
admet-2626	294	45	24	24	NUM
admet-2626	294	46	]	]	PUNCT
admet-2626	294	47	and	and	CCONJ
admet-2626	294	48	(	(	PUNCT
admet-2626	294	49	c	c	NOUN
admet-2626	294	50	)	)	PUNCT
admet-2626	294	51	brigatinib	brigatinib	NOUN
admet-2626	294	52	[	[	X
admet-2626	294	53	25	25	NUM
admet-2626	294	54	]	]	PUNCT
admet-2626	294	55	,	,	PUNCT
admet-2626	294	56	ordered	order	VERB
admet-2626	294	57	by	by	ADP
admet-2626	294	58	increasing	increase	VERB
admet-2626	294	59	intrinsic	intrinsic	ADJ
admet-2626	294	60	solubility	solubility	NOUN
admet-2626	294	61	figure	figure	NOUN
admet-2626	294	62	4	4	NUM
admet-2626	294	63	shows	show	VERB
admet-2626	294	64	the	the	DET
admet-2626	294	65	log	log	NOUN
admet-2626	294	66	s	s	NOUN
admet-2626	294	67	-	-	PUNCT
admet-2626	294	68	ph	ph	ADJ
admet-2626	294	69	profiles	profile	NOUN
admet-2626	294	70	of	of	ADP
admet-2626	294	71	three	three	NUM
admet-2626	294	72	selected	select	VERB
admet-2626	294	73	ampholytes	ampholyte	NOUN
admet-2626	294	74	,	,	PUNCT
admet-2626	294	75	arranged	arrange	VERB
admet-2626	294	76	in	in	ADP
admet-2626	294	77	increasing	increase	VERB
admet-2626	294	78	order	order	NOUN
admet-2626	294	79	of	of	ADP
admet-2626	294	80	intrinsic	intrinsic	ADJ
admet-2626	294	81	solubility	solubility	NOUN
admet-2626	294	82	.	.	PUNCT
admet-2626	295	1	the	the	DET
admet-2626	295	2	differences	difference	NOUN
admet-2626	295	3	in	in	ADP
admet-2626	295	4	the	the	DET
admet-2626	295	5	curves	curve	NOUN
admet-2626	295	6	between	between	ADP
admet-2626	295	7	the	the	DET
admet-2626	295	8	low	low	ADJ
admet-2626	295	9	ionic	ionic	ADJ
admet-2626	295	10	strengths	strength	NOUN
admet-2626	295	11	(	(	PUNCT
admet-2626	295	12	solid	solid	ADJ
admet-2626	295	13	green	green	NOUN
admet-2626	295	14	)	)	PUNCT
admet-2626	295	15	and	and	CCONJ
admet-2626	295	16	the	the	DET
admet-2626	295	17	reference	reference	NOUN
admet-2626	295	18	level	level	NOUN
admet-2626	295	19	(	(	PUNCT
admet-2626	295	20	dashed	dash	VERB
admet-2626	295	21	)	)	PUNCT
admet-2626	295	22	curves	curve	NOUN
admet-2626	295	23	in	in	ADP
admet-2626	295	24	the	the	DET
admet-2626	295	25	first	first	ADJ
admet-2626	295	26	two	two	NUM
admet-2626	295	27	examples	example	NOUN
admet-2626	295	28	may	may	AUX
admet-2626	295	29	be	be	AUX
admet-2626	295	30	anticipated	anticipate	VERB
admet-2626	295	31	based	base	VERB
admet-2626	295	32	on	on	ADP
admet-2626	295	33	the	the	DET
admet-2626	295	34	preceding	precede	VERB
admet-2626	295	35	acid	acid	ADJ
admet-2626	295	36	-	-	PUNCT
admet-2626	295	37	base	base	NOUN
admet-2626	295	38	discussions	discussion	NOUN
admet-2626	295	39	.	.	PUNCT
admet-2626	296	1	figure	figure	NOUN
admet-2626	296	2	4	4	NUM
admet-2626	296	3	.	.	PUNCT
admet-2626	296	4	simulated	simulate	VERB
admet-2626	296	5	log	log	NOUN
admet-2626	296	6	s	s	NOUN
admet-2626	296	7	-	-	PUNCT
admet-2626	296	8	ph	ph	ADJ
admet-2626	296	9	profiles	profile	NOUN
admet-2626	296	10	of	of	ADP
admet-2626	296	11	three	three	NUM
admet-2626	296	12	ampholytes	ampholyte	NOUN
admet-2626	296	13	:	:	PUNCT
admet-2626	296	14	(	(	PUNCT
admet-2626	296	15	a	a	X
admet-2626	296	16	)	)	PUNCT
admet-2626	296	17	celecoxib	celecoxib	NOUN
admet-2626	297	1	[	[	X
admet-2626	297	2	17	17	NUM
admet-2626	297	3	]	]	PUNCT
admet-2626	297	4	,	,	PUNCT
admet-2626	297	5	(	(	PUNCT
admet-2626	297	6	b	b	X
admet-2626	297	7	)	)	PUNCT
admet-2626	297	8	mycophenolate	mycophenolate	NOUN
admet-2626	297	9	mofetil	mofetil	NOUN
admet-2626	298	1	[	[	X
admet-2626	298	2	17	17	NUM
admet-2626	298	3	]	]	PUNCT
admet-2626	298	4	and	and	CCONJ
admet-2626	298	5	(	(	PUNCT
admet-2626	298	6	c	c	NOUN
admet-2626	298	7	)	)	PUNCT
admet-2626	298	8	l	l	NOUN
admet-2626	298	9	-	-	NOUN
admet-2626	298	10	lysine	lysine	NOUN
admet-2626	298	11	[	[	X
admet-2626	298	12	27	27	NUM
admet-2626	298	13	]	]	PUNCT
admet-2626	298	14	,	,	PUNCT
admet-2626	298	15	ordered	order	VERB
admet-2626	298	16	by	by	ADP
admet-2626	298	17	increasing	increase	VERB
admet-2626	298	18	intrinsic	intrinsic	ADJ
admet-2626	298	19	solubility	solubility	NOUN
admet-2626	298	20	.	.	PUNCT
admet-2626	299	1	the	the	DET
admet-2626	299	2	red	red	ADJ
admet-2626	299	3	dash	dash	NOUN
admet-2626	299	4	-	-	PUNCT
admet-2626	299	5	dot	dot	NOUN
admet-2626	299	6	curve	curve	NOUN
admet-2626	299	7	in	in	ADP
admet-2626	299	8	frame	frame	NOUN
admet-2626	299	9	(	(	PUNCT
admet-2626	299	10	c	c	NOUN
admet-2626	299	11	)	)	PUNCT
admet-2626	299	12	refers	refer	VERB
admet-2626	299	13	to	to	ADP
admet-2626	299	14	the	the	DET
admet-2626	299	15	ionic	ionic	ADJ
admet-2626	299	16	strength	strength	NOUN
admet-2626	299	17	as	as	ADP
admet-2626	299	18	a	a	DET
admet-2626	299	19	function	function	NOUN
admet-2626	299	20	of	of	ADP
admet-2626	299	21	ph	ph	NOUN
admet-2626	299	22	except	except	SCONJ
admet-2626	299	23	for	for	ADP
admet-2626	299	24	lysine	lysine	NOUN
admet-2626	299	25	,	,	PUNCT
admet-2626	299	26	the	the	DET
admet-2626	299	27	ampholytes	ampholyte	NOUN
admet-2626	299	28	(	(	PUNCT
admet-2626	299	29	table	table	NOUN
admet-2626	299	30	4	4	NUM
admet-2626	299	31	)	)	PUNCT
admet-2626	299	32	show	show	VERB
admet-2626	299	33	positive	positive	ADJ
admet-2626	299	34	log	log	NOUN
admet-2626	299	35	s0	s0	NOUN
admet-2626	299	36	i	i	PRON
admet-2626	299	37	log	log	VERB
admet-2626	299	38	s0	s0	PROPN
admet-2626	299	39	ref	ref	NOUN
admet-2626	299	40	differences	difference	NOUN
admet-2626	299	41	of	of	ADP
admet-2626	299	42	0.029	0.029	NUM
admet-2626	299	43	to	to	ADP
admet-2626	299	44	0.051	0.051	NUM
admet-2626	299	45	(	(	PUNCT
admet-2626	299	46	less	less	ADV
admet-2626	299	47	soluble	soluble	ADJ
admet-2626	299	48	with	with	ADP
admet-2626	299	49	increased	increase	VERB
admet-2626	299	50	salt	salt	NOUN
admet-2626	299	51	)	)	PUNCT
admet-2626	299	52	.	.	PUNCT
admet-2626	300	1	lysine	lysine	NOUN
admet-2626	300	2	appears	appear	VERB
admet-2626	300	3	to	to	PART
admet-2626	300	4	show	show	VERB
admet-2626	300	5	negative	negative	ADJ
admet-2626	300	6	(	(	PUNCT
admet-2626	300	7	salting	salt	VERB
admet-2626	300	8	-	-	PUNCT
admet-2626	300	9	in	in	ADP
admet-2626	300	10	)	)	PUNCT
admet-2626	300	11	differences	difference	NOUN
admet-2626	300	12	of	of	ADP
admet-2626	300	13	-0.048	-0.048	NOUN
admet-2626	300	14	(	(	PUNCT
admet-2626	300	15	1.1	1.1	NUM
admet-2626	300	16	-	-	ADJ
admet-2626	300	17	fold	fold	ADJ
admet-2626	300	18	excess	excess	ADJ
admet-2626	300	19	solid	solid	ADJ
admet-2626	300	20	added	add	VERB
admet-2626	300	21	)	)	PUNCT
admet-2626	300	22	or	or	CCONJ
admet-2626	300	23	-0.056	-0.056	NUM
admet-2626	300	24	(	(	PUNCT
admet-2626	300	25	2	2	NUM
admet-2626	300	26	-	-	ADJ
admet-2626	300	27	fold	fold	ADJ
admet-2626	300	28	excess	excess	NOUN
admet-2626	300	29	)	)	PUNCT
admet-2626	300	30	more	more	ADV
admet-2626	300	31	soluble	soluble	ADJ
admet-2626	300	32	with	with	ADP
admet-2626	300	33	increased	increase	VERB
admet-2626	300	34	salt	salt	NOUN
admet-2626	300	35	.	.	PUNCT
admet-2626	301	1	this	this	DET
admet-2626	301	2	salting	salt	VERB
admet-2626	301	3	-	-	PUNCT
admet-2626	301	4	in	in	ADP
admet-2626	301	5	value	value	NOUN
admet-2626	301	6	appears	appear	VERB
admet-2626	301	7	to	to	PART
admet-2626	301	8	be	be	AUX
admet-2626	301	9	entirely	entirely	ADV
admet-2626	301	10	ksalt	ksalt	NOUN
admet-2626	301	11	driven	drive	VERB
admet-2626	301	12	,	,	PUNCT
admet-2626	301	13	with	with	ADP
admet-2626	301	14	no	no	DET
admet-2626	301	15	contribution	contribution	NOUN
admet-2626	301	16	from	from	ADP
admet-2626	301	17	the	the	DET
admet-2626	301	18	traditional	traditional	ADJ
admet-2626	301	19	srht	srht	NOUN
admet-2626	301	20	eq	eq	ADP
admet-2626	301	21	.	.	PROPN
admet-2626	301	22	a3	a3	PROPN
admet-2626	301	23	.	.	PUNCT
admet-2626	302	1	the	the	DET
admet-2626	302	2	dash	dash	NOUN
admet-2626	302	3	-	-	PUNCT
admet-2626	302	4	dot	dot	NOUN
admet-2626	302	5	(	(	PUNCT
admet-2626	302	6	red	red	ADJ
admet-2626	302	7	)	)	PUNCT
admet-2626	302	8	curve	curve	NOUN
admet-2626	302	9	in	in	ADP
admet-2626	302	10	figure	figure	NOUN
admet-2626	302	11	4c	4c	NOUN
admet-2626	302	12	shows	show	VERB
admet-2626	302	13	the	the	DET
admet-2626	302	14	asymmetric	asymmetric	ADJ
admet-2626	302	15	lysine	lysine	NOUN
admet-2626	302	16	ionic	ionic	ADJ
admet-2626	302	17	strength	strength	NOUN
admet-2626	302	18	profile	profile	NOUN
admet-2626	302	19	as	as	ADP
admet-2626	302	20	a	a	DET
admet-2626	302	21	function	function	NOUN
admet-2626	302	22	of	of	ADP
admet-2626	302	23	ph	ph	PROPN
admet-2626	302	24	.	.	PROPN
admet-2626	302	25	ionic	ionic	ADJ
admet-2626	302	26	strength	strength	NOUN
admet-2626	302	27	values	value	NOUN
admet-2626	302	28	exceeding	exceed	VERB
admet-2626	302	29	7	7	NUM
admet-2626	302	30	m	m	NOUN
admet-2626	302	31	are	be	AUX
admet-2626	302	32	reached	reach	VERB
admet-2626	302	33	as	as	SCONJ
admet-2626	302	34	ph	ph	NOUN
admet-2626	302	35	is	be	AUX
admet-2626	302	36	altered	alter	VERB
admet-2626	302	37	from	from	ADP
admet-2626	302	38	the	the	DET
admet-2626	302	39	phw	phw	NOUN
admet-2626	302	40	.	.	PUNCT
admet-2626	303	1	limitations	limitation	NOUN
admet-2626	303	2	in	in	ADP
admet-2626	303	3	transforming	transform	VERB
admet-2626	303	4	sw	sw	PROPN
admet-2626	303	5	solubility	solubility	NOUN
admet-2626	303	6	in	in	ADP
admet-2626	303	7	pure	pure	ADJ
admet-2626	303	8	water	water	NOUN
admet-2626	303	9	to	to	ADP
admet-2626	303	10	physiologically	physiologically	ADV
admet-2626	303	11	-	-	PUNCT
admet-2626	303	12	appropriate	appropriate	ADJ
admet-2626	303	13	solubility	solubility	NOUN
admet-2626	303	14	-	-	PUNCT
admet-2626	303	15	ph	ph	NOUN
admet-2626	303	16	in	in	ADP
admet-2626	303	17	the	the	DET
admet-2626	303	18	absence	absence	NOUN
admet-2626	303	19	of	of	ADP
admet-2626	303	20	high	high	ADJ
admet-2626	303	21	quality	quality	NOUN
admet-2626	303	22	sw	sw	PROPN
admet-2626	303	23	solubility	solubility	NOUN
admet-2626	303	24	and	and	CCONJ
admet-2626	303	25	pka	pka	PROPN
admet-2626	303	26	measurement	measurement	NOUN
admet-2626	303	27	,	,	PUNCT
admet-2626	303	28	the	the	DET
admet-2626	303	29	additional	additional	ADJ
admet-2626	303	30	‘	'	PUNCT
admet-2626	303	31	fine	fine	ADJ
admet-2626	303	32	tuning	tuning	NOUN
admet-2626	303	33	’	'	PUNCT
admet-2626	303	34	corrections	correction	NOUN
admet-2626	303	35	for	for	ADP
admet-2626	303	36	the	the	DET
admet-2626	303	37	ionic	ionic	ADJ
admet-2626	303	38	strength	strength	NOUN
admet-2626	303	39	effect	effect	NOUN
admet-2626	303	40	would	would	AUX
admet-2626	303	41	hardly	hardly	ADV
admet-2626	303	42	be	be	AUX
admet-2626	303	43	worthwhile	worthwhile	ADJ
admet-2626	303	44	.	.	PUNCT
admet-2626	304	1	the	the	DET
admet-2626	304	2	uncertainty	uncertainty	NOUN
admet-2626	304	3	in	in	ADP
admet-2626	304	4	the	the	DET
admet-2626	304	5	conversion	conversion	NOUN
admet-2626	304	6	of	of	ADP
admet-2626	304	7	sw	sw	PROPN
admet-2626	304	8	(	(	PUNCT
admet-2626	304	9	typically	typically	ADV
admet-2626	304	10	at	at	ADP
admet-2626	304	11	iw	iw	PROPN
admet-2626	304	12	~	~	PUNCT
admet-2626	304	13	0	0	NUM
admet-2626	304	14	m	m	NOUN
admet-2626	304	15	)	)	PUNCT
admet-2626	304	16	to	to	PART
admet-2626	304	17	s0	s0	PROPN
admet-2626	304	18	at	at	ADP
admet-2626	304	19	iref	iref	NOUN
admet-2626	304	20	=	=	PUNCT
admet-2626	304	21	0.15	0.15	NUM
admet-2626	304	22	m	m	NOUN
admet-2626	304	23	and	and	CCONJ
admet-2626	304	24	consequently	consequently	ADV
admet-2626	304	25	extending	extend	VERB
admet-2626	304	26	that	that	PRON
admet-2626	304	27	into	into	ADP
admet-2626	304	28	a	a	DET
admet-2626	304	29	log	log	NOUN
admet-2626	304	30	s	s	NOUN
admet-2626	304	31	-	-	PUNCT
admet-2626	304	32	ph	ph	ADJ
admet-2626	304	33	reference	reference	NOUN
admet-2626	304	34	-	-	PUNCT
admet-2626	304	35	state	state	NOUN
admet-2626	304	36	profile	profile	NOUN
admet-2626	304	37	probably	probably	ADV
admet-2626	304	38	has	have	VERB
admet-2626	304	39	as	as	ADV
admet-2626	304	40	much	much	ADJ
admet-2626	304	41	to	to	PART
admet-2626	304	42	do	do	VERB
admet-2626	304	43	with	with	ADP
admet-2626	304	44	the	the	DET
admet-2626	304	45	reliability	reliability	NOUN
admet-2626	304	46	of	of	ADP
admet-2626	304	47	the	the	DET
admet-2626	304	48	measured	measured	ADJ
admet-2626	304	49	sw	sw	PROPN
admet-2626	304	50	and	and	CCONJ
admet-2626	304	51	the	the	DET
admet-2626	304	52	provided	provide	VERB
admet-2626	304	53	iref	iref	NOUN
admet-2626	304	54	-based	-based	PROPN
admet-2626	304	55	pka	pka	PROPN
admet-2626	304	56	values	value	NOUN
admet-2626	304	57	,	,	PUNCT
admet-2626	304	58	as	as	ADP
admet-2626	304	59	with	with	ADP
admet-2626	304	60	the	the	DET
admet-2626	304	61	modified	modify	VERB
admet-2626	304	62	srht	srht	NOUN
admet-2626	304	63	model	model	NOUN
admet-2626	304	64	described	describe	VERB
admet-2626	304	65	here	here	ADV
admet-2626	304	66	.	.	PUNCT
admet-2626	305	1	the	the	DET
admet-2626	305	2	following	follow	VERB
admet-2626	305	3	shortfalls	shortfall	NOUN
admet-2626	305	4	underlie	underlie	VERB
admet-2626	305	5	the	the	DET
admet-2626	305	6	challenge	challenge	NOUN
admet-2626	305	7	in	in	ADP
admet-2626	305	8	validating	validate	VERB
admet-2626	305	9	the	the	DET
admet-2626	305	10	conversion	conversion	NOUN
admet-2626	305	11	procedure	procedure	NOUN
admet-2626	305	12	we	we	PRON
admet-2626	305	13	discussed	discuss	VERB
admet-2626	305	14	:	:	PUNCT
admet-2626	305	15	as	as	ADP
admet-2626	305	16	part	part	NOUN
admet-2626	305	17	of	of	ADP
admet-2626	305	18	the	the	DET
admet-2626	305	19	sw	sw	PROPN
admet-2626	305	20	assay	assay	PROPN
admet-2626	305	21	,	,	PUNCT
admet-2626	305	22	measurement	measurement	NOUN
admet-2626	305	23	of	of	ADP
admet-2626	305	24	the	the	DET
admet-2626	305	25	phw	phw	NOUN
admet-2626	305	26	would	would	AUX
admet-2626	305	27	be	be	AUX
admet-2626	305	28	helpful	helpful	ADJ
admet-2626	305	29	,	,	PUNCT
admet-2626	305	30	as	as	SCONJ
admet-2626	305	31	this	this	PRON
admet-2626	305	32	would	would	AUX
admet-2626	305	33	allow	allow	VERB
admet-2626	305	34	for	for	ADP
admet-2626	305	35	recognition	recognition	NOUN
admet-2626	305	36	/	/	SYM
admet-2626	305	37	correction	correction	NOUN
admet-2626	305	38	of	of	ADP
admet-2626	305	39	the	the	DET
admet-2626	305	40	effects	effect	NOUN
admet-2626	305	41	of	of	ADP
admet-2626	305	42	impurities	impurity	NOUN
admet-2626	305	43	(	(	PUNCT
admet-2626	305	44	e.g.	e.g.	ADV
admet-2626	305	45	co2	co2	NOUN
admet-2626	305	46	)	)	PUNCT
admet-2626	305	47	and	and	CCONJ
admet-2626	305	48	could	could	AUX
admet-2626	305	49	lead	lead	VERB
admet-2626	305	50	to	to	ADP
admet-2626	305	51	more	more	ADV
admet-2626	305	52	certain	certain	ADJ
admet-2626	305	53	sw	sw	PROPN
admet-2626	305	54	measurement	measurement	PROPN
admet-2626	305	55	.	.	PUNCT
admet-2626	306	1	i.	i.	PROPN
admet-2626	306	2	specified	specify	VERB
admet-2626	306	3	electrode	electrode	NOUN
admet-2626	306	4	calibration	calibration	NOUN
admet-2626	306	5	/	/	SYM
admet-2626	306	6	standardization	standardization	NOUN
admet-2626	306	7	(	(	PUNCT
admet-2626	306	8	e.g.	e.g.	ADV
admet-2626	306	9	junction	junction	NOUN
admet-2626	306	10	potential	potential	NOUN
admet-2626	306	11	determined	determine	VERB
admet-2626	306	12	from	from	ADP
admet-2626	306	13	blank	blank	ADJ
admet-2626	306	14	titrations	titration	NOUN
admet-2626	306	15	see	see	VERB
admet-2626	306	16	appendix	appendix	NOUN
admet-2626	306	17	b	b	NOUN
admet-2626	306	18	)	)	PUNCT
admet-2626	306	19	would	would	AUX
admet-2626	306	20	allow	allow	VERB
admet-2626	306	21	for	for	ADP
admet-2626	306	22	the	the	DET
admet-2626	306	23	confident	confident	ADJ
admet-2626	306	24	conversion	conversion	NOUN
admet-2626	306	25	of	of	ADP
admet-2626	306	26	operational	operational	ADJ
admet-2626	306	27	ph	ph	PROPN
admet-2626	306	28	(	(	PUNCT
admet-2626	306	29	pah	pah	PROPN
admet-2626	306	30	)	)	PUNCT
admet-2626	306	31	to	to	ADP
admet-2626	306	32	concentration	concentration	NOUN
admet-2626	306	33	-	-	PUNCT
admet-2626	306	34	based	base	VERB
admet-2626	306	35	pch	pch	ADJ
admet-2626	306	36	,	,	PUNCT
admet-2626	306	37	so	so	SCONJ
admet-2626	306	38	constants	constant	NOUN
admet-2626	306	39	could	could	AUX
admet-2626	306	40	be	be	AUX
admet-2626	306	41	reported	report	VERB
admet-2626	306	42	consistently	consistently	ADV
admet-2626	306	43	at	at	ADP
admet-2626	306	44	the	the	DET
admet-2626	306	45	‘	'	PUNCT
admet-2626	306	46	constant	constant	ADJ
admet-2626	306	47	ionic	ionic	ADJ
admet-2626	306	48	medium	medium	ADJ
admet-2626	306	49	’	'	PUNCT
admet-2626	306	50	activity	activity	NOUN
admet-2626	306	51	scale	scale	NOUN
admet-2626	306	52	.	.	PUNCT
admet-2626	307	1	this	this	PRON
admet-2626	307	2	would	would	AUX
admet-2626	307	3	be	be	AUX
admet-2626	307	4	particularly	particularly	ADV
admet-2626	307	5	important	important	ADJ
admet-2626	307	6	if	if	SCONJ
admet-2626	307	7	phw	phw	NOUN
admet-2626	307	8	were	be	AUX
admet-2626	307	9	measured	measure	VERB
admet-2626	307	10	in	in	ADP
admet-2626	307	11	very	very	ADV
admet-2626	307	12	acidic	acidic	ADJ
admet-2626	307	13	/	/	SYM
admet-2626	307	14	basic	basic	ADJ
admet-2626	307	15	solutions	solution	NOUN
admet-2626	307	16	.	.	PUNCT
admet-2626	308	1	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	308	2	a.	a.	NOUN
admet-2626	308	3	avdeef	avdeef	PROPN
admet-2626	308	4	admet	admet	PROPN
admet-2626	308	5	&	&	CCONJ
admet-2626	308	6	dmpk	dmpk	PROPN
admet-2626	308	7	13(1	13(1	NUM
admet-2626	308	8	)	)	PUNCT
admet-2626	308	9	(	(	PUNCT
admet-2626	308	10	2025	2025	NUM
admet-2626	308	11	)	)	PUNCT
admet-2626	308	12	2626	2626	NUM
admet-2626	308	13	12	12	NUM
admet-2626	308	14	ii	ii	NOUN
admet-2626	308	15	.	.	PUNCT
admet-2626	309	1	for	for	ADP
admet-2626	309	2	relatively	relatively	ADV
admet-2626	309	3	soluble	soluble	ADJ
admet-2626	309	4	drugs	drug	NOUN
admet-2626	309	5	,	,	PUNCT
admet-2626	309	6	the	the	DET
admet-2626	309	7	actual	actual	ADJ
admet-2626	309	8	weight	weight	NOUN
admet-2626	309	9	of	of	ADP
admet-2626	309	10	solid	solid	ADJ
admet-2626	309	11	added	add	VERB
admet-2626	309	12	to	to	PART
admet-2626	309	13	produce	produce	VERB
admet-2626	309	14	a	a	DET
admet-2626	309	15	saturated	saturate	VERB
admet-2626	309	16	solution	solution	NOUN
admet-2626	309	17	would	would	AUX
admet-2626	309	18	be	be	AUX
admet-2626	309	19	helpful	helpful	ADJ
admet-2626	309	20	to	to	PART
admet-2626	309	21	report	report	VERB
admet-2626	309	22	,	,	PUNCT
admet-2626	309	23	since	since	SCONJ
admet-2626	309	24	the	the	DET
admet-2626	309	25	conversion	conversion	NOUN
admet-2626	309	26	process	process	NOUN
admet-2626	309	27	may	may	AUX
admet-2626	309	28	depend	depend	VERB
admet-2626	309	29	on	on	ADP
admet-2626	309	30	the	the	DET
admet-2626	309	31	excess	excess	ADJ
admet-2626	309	32	solid	solid	ADJ
admet-2626	309	33	added	add	VERB
admet-2626	309	34	(	(	PUNCT
admet-2626	309	35	e.g.	e.g.	ADV
admet-2626	309	36	mellitic	mellitic	ADJ
admet-2626	309	37	acid	acid	NOUN
admet-2626	309	38	in	in	ADP
admet-2626	309	39	table	table	NOUN
admet-2626	309	40	2	2	NUM
admet-2626	309	41	,	,	PUNCT
admet-2626	309	42	lysine	lysine	NOUN
admet-2626	309	43	in	in	ADP
admet-2626	309	44	table	table	NOUN
admet-2626	309	45	4	4	NUM
admet-2626	309	46	)	)	PUNCT
admet-2626	309	47	.	.	PUNCT
admet-2626	310	1	iii	iii	X
admet-2626	310	2	.	.	PUNCT
admet-2626	311	1	for	for	ADP
admet-2626	311	2	very	very	ADV
admet-2626	311	3	soluble	soluble	ADJ
admet-2626	311	4	molecules	molecule	NOUN
admet-2626	311	5	,	,	PUNCT
admet-2626	311	6	the	the	DET
admet-2626	311	7	added	add	VERB
admet-2626	311	8	amount	amount	NOUN
admet-2626	311	9	of	of	ADP
admet-2626	311	10	solid	solid	ADJ
admet-2626	311	11	would	would	AUX
admet-2626	311	12	be	be	AUX
admet-2626	311	13	expected	expect	VERB
admet-2626	311	14	to	to	PART
admet-2626	311	15	change	change	VERB
admet-2626	311	16	the	the	DET
admet-2626	311	17	total	total	ADJ
admet-2626	311	18	solution	solution	NOUN
admet-2626	311	19	volume	volume	NOUN
admet-2626	311	20	.	.	PUNCT
admet-2626	312	1	measurement	measurement	NOUN
admet-2626	312	2	or	or	CCONJ
admet-2626	312	3	estimation	estimation	NOUN
admet-2626	312	4	of	of	ADP
admet-2626	312	5	density	density	NOUN
admet-2626	312	6	of	of	ADP
admet-2626	312	7	the	the	DET
admet-2626	312	8	suspension	suspension	NOUN
admet-2626	312	9	(	(	PUNCT
admet-2626	312	10	e.g.	e.g.	ADV
admet-2626	312	11	applying	apply	VERB
admet-2626	312	12	mcgowan	mcgowan	PROPN
admet-2626	312	13	molar	molar	PROPN
admet-2626	312	14	volume	volume	NOUN
admet-2626	312	15	)	)	PUNCT
admet-2626	312	16	would	would	AUX
admet-2626	312	17	allow	allow	VERB
admet-2626	312	18	the	the	DET
admet-2626	312	19	conversion	conversion	NOUN
admet-2626	312	20	of	of	ADP
admet-2626	312	21	concentrations	concentration	NOUN
admet-2626	312	22	from	from	ADP
admet-2626	312	23	molality	molality	NOUN
admet-2626	312	24	to	to	ADP
admet-2626	312	25	molarity	molarity	NOUN
admet-2626	312	26	units	unit	NOUN
admet-2626	312	27	.	.	PUNCT
admet-2626	313	1	iv	iv	X
admet-2626	313	2	.	.	PUNCT
admet-2626	314	1	the	the	DET
admet-2626	314	2	hydration	hydration	NOUN
admet-2626	314	3	numbers	number	NOUN
admet-2626	314	4	,	,	PUNCT
admet-2626	314	5	hj	hj	PROPN
admet-2626	314	6	(	(	PUNCT
admet-2626	314	7	i.e.	i.e.	X
admet-2626	314	8	the	the	DET
admet-2626	314	9	number	number	NOUN
admet-2626	314	10	of	of	ADP
admet-2626	314	11	water	water	NOUN
admet-2626	314	12	molecules	molecule	NOUN
admet-2626	314	13	sequestered	sequester	VERB
admet-2626	314	14	in	in	ADP
admet-2626	314	15	the	the	DET
admet-2626	314	16	solvation	solvation	NOUN
admet-2626	314	17	shell	shell	NOUN
admet-2626	314	18	of	of	ADP
admet-2626	314	19	the	the	DET
admet-2626	314	20	jth	jth	PROPN
admet-2626	314	21	species	species	PROPN
admet-2626	314	22	;	;	PUNCT
admet-2626	314	23	cf	cf	X
admet-2626	314	24	.	.	PUNCT
admet-2626	315	1	appendix	appendix	VERB
admet-2626	315	2	a	a	PRON
admet-2626	315	3	)	)	PUNCT
admet-2626	315	4	,	,	PUNCT
admet-2626	315	5	in	in	ADP
admet-2626	315	6	the	the	DET
admet-2626	315	7	srht	srht	NOUN
admet-2626	315	8	model	model	NOUN
admet-2626	315	9	for	for	ADP
admet-2626	315	10	charged	charge	VERB
admet-2626	315	11	and	and	CCONJ
admet-2626	315	12	uncharged	uncharged	ADJ
admet-2626	315	13	solutes	solute	NOUN
admet-2626	315	14	are	be	AUX
admet-2626	315	15	only	only	ADV
admet-2626	315	16	tentatively	tentatively	ADV
admet-2626	315	17	defined	define	VERB
admet-2626	315	18	for	for	ADP
admet-2626	315	19	druglike	druglike	ADJ
admet-2626	315	20	molecules	molecule	NOUN
admet-2626	315	21	,	,	PUNCT
admet-2626	315	22	which	which	PRON
admet-2626	315	23	contributes	contribute	VERB
admet-2626	315	24	to	to	ADP
admet-2626	315	25	the	the	DET
admet-2626	315	26	uncertainty	uncertainty	NOUN
admet-2626	315	27	in	in	ADP
admet-2626	315	28	the	the	DET
admet-2626	315	29	srht	srht	NOUN
admet-2626	315	30	model	model	NOUN
admet-2626	315	31	[	[	X
admet-2626	315	32	14	14	NUM
admet-2626	315	33	]	]	PUNCT
admet-2626	315	34	.	.	PUNCT
admet-2626	316	1	v.	v.	ADP
admet-2626	316	2	experimental	experimental	ADJ
admet-2626	316	3	activity	activity	NOUN
admet-2626	316	4	coefficients	coefficient	NOUN
admet-2626	316	5	are	be	AUX
admet-2626	316	6	scarcely	scarcely	ADV
admet-2626	316	7	available	available	ADJ
admet-2626	316	8	for	for	ADP
admet-2626	316	9	druglike	druglike	ADJ
admet-2626	316	10	molecules	molecule	NOUN
admet-2626	316	11	,	,	PUNCT
admet-2626	316	12	to	to	PART
admet-2626	316	13	test	test	VERB
admet-2626	316	14	reliability	reliability	NOUN
admet-2626	316	15	of	of	ADP
admet-2626	316	16	the	the	DET
admet-2626	316	17	modified	modify	VERB
admet-2626	316	18	srht	srht	PROPN
admet-2626	316	19	model	model	PROPN
admet-2626	316	20	.	.	PUNCT
admet-2626	317	1	vi	vi	X
admet-2626	317	2	.	.	PUNCT
admet-2626	318	1	an	an	DET
admet-2626	318	2	actual	actual	ADJ
admet-2626	318	3	measurement	measurement	NOUN
admet-2626	318	4	of	of	ADP
admet-2626	318	5	a	a	DET
admet-2626	318	6	log	log	NOUN
admet-2626	318	7	s	s	NOUN
admet-2626	318	8	-	-	PUNCT
admet-2626	318	9	ph	ph	ADJ
admet-2626	318	10	profile	profile	NOUN
admet-2626	318	11	covering	cover	VERB
admet-2626	318	12	a	a	DET
admet-2626	318	13	range	range	NOUN
admet-2626	318	14	of	of	ADP
admet-2626	318	15	ph	ph	NOUN
admet-2626	318	16	would	would	AUX
admet-2626	318	17	be	be	AUX
admet-2626	318	18	a	a	DET
admet-2626	318	19	helpful	helpful	ADJ
admet-2626	318	20	test	test	NOUN
admet-2626	318	21	of	of	ADP
admet-2626	318	22	the	the	DET
admet-2626	318	23	reliability	reliability	NOUN
admet-2626	318	24	of	of	ADP
admet-2626	318	25	the	the	DET
admet-2626	318	26	conversion	conversion	NOUN
admet-2626	318	27	process	process	NOUN
admet-2626	318	28	described	describe	VERB
admet-2626	318	29	in	in	ADP
admet-2626	318	30	this	this	DET
admet-2626	318	31	commentary	commentary	NOUN
admet-2626	318	32	,	,	PUNCT
admet-2626	318	33	particularly	particularly	ADV
admet-2626	318	34	in	in	ADP
admet-2626	318	35	the	the	DET
admet-2626	318	36	case	case	NOUN
admet-2626	318	37	of	of	ADP
admet-2626	318	38	lysine	lysine	NOUN
admet-2626	318	39	.	.	PUNCT
admet-2626	319	1	usually	usually	ADV
admet-2626	319	2	,	,	PUNCT
admet-2626	319	3	such	such	ADJ
admet-2626	319	4	measurements	measurement	NOUN
admet-2626	319	5	are	be	AUX
admet-2626	319	6	done	do	VERB
admet-2626	319	7	in	in	ADP
admet-2626	319	8	buffered	buffer	VERB
admet-2626	319	9	solutions	solution	NOUN
admet-2626	319	10	,	,	PUNCT
admet-2626	319	11	rather	rather	ADV
admet-2626	319	12	than	than	ADP
admet-2626	319	13	simply	simply	ADV
admet-2626	319	14	in	in	ADP
admet-2626	319	15	water	water	NOUN
admet-2626	319	16	.	.	PUNCT
admet-2626	320	1	we	we	PRON
admet-2626	320	2	have	have	AUX
admet-2626	320	3	not	not	PART
admet-2626	320	4	been	be	AUX
admet-2626	320	5	able	able	ADJ
admet-2626	320	6	to	to	PART
admet-2626	320	7	find	find	VERB
admet-2626	320	8	reliable	reliable	ADJ
admet-2626	320	9	published	publish	VERB
admet-2626	320	10	results	result	NOUN
admet-2626	320	11	of	of	ADP
admet-2626	320	12	lysine	lysine	NOUN
admet-2626	320	13	solubility	solubility	NOUN
admet-2626	320	14	as	as	ADP
admet-2626	320	15	a	a	DET
admet-2626	320	16	measured	measured	ADJ
admet-2626	320	17	function	function	NOUN
admet-2626	320	18	of	of	ADP
admet-2626	320	19	ph	ph	NOUN
admet-2626	320	20	in	in	ADP
admet-2626	320	21	unbuffered	unbuffered	ADJ
admet-2626	320	22	solutions	solution	NOUN
admet-2626	320	23	.	.	PUNCT
admet-2626	321	1	the	the	DET
admet-2626	321	2	lysine	lysine	NOUN
admet-2626	321	3	log	log	NOUN
admet-2626	321	4	s	s	NOUN
admet-2626	321	5	-	-	PUNCT
admet-2626	321	6	ph	ph	ADJ
admet-2626	321	7	data	datum	NOUN
admet-2626	321	8	from	from	ADP
admet-2626	321	9	amend	amend	NOUN
admet-2626	321	10	and	and	CCONJ
admet-2626	321	11	helgeson	helgeson	NOUN
admet-2626	321	12	[	[	X
admet-2626	321	13	56	56	NUM
admet-2626	321	14	]	]	PUNCT
admet-2626	321	15	are	be	AUX
admet-2626	321	16	inconsistent	inconsistent	ADJ
admet-2626	321	17	with	with	ADP
admet-2626	321	18	the	the	DET
admet-2626	321	19	sw	sw	PROPN
admet-2626	321	20	value	value	NOUN
admet-2626	321	21	reported	report	VERB
admet-2626	321	22	by	by	ADP
admet-2626	321	23	dooley	dooley	NOUN
admet-2626	321	24	and	and	CCONJ
admet-2626	321	25	castellino	castellino	NOUN
admet-2626	322	1	[	[	X
admet-2626	322	2	27	27	NUM
admet-2626	322	3	]	]	PUNCT
admet-2626	322	4	.	.	PUNCT
admet-2626	323	1	nor	nor	CCONJ
admet-2626	323	2	is	be	AUX
admet-2626	323	3	the	the	DET
admet-2626	323	4	shape	shape	NOUN
admet-2626	323	5	of	of	ADP
admet-2626	323	6	the	the	DET
admet-2626	323	7	curve	curve	NOUN
admet-2626	323	8	[	[	X
admet-2626	323	9	56	56	NUM
admet-2626	323	10	]	]	X
admet-2626	323	11	consistent	consistent	ADJ
admet-2626	323	12	with	with	ADP
admet-2626	323	13	the	the	DET
admet-2626	323	14	value	value	NOUN
admet-2626	323	15	of	of	ADP
admet-2626	323	16	pka3	pka3	NOUN
admet-2626	323	17	.	.	PUNCT
admet-2626	324	1	zhang	zhang	PROPN
admet-2626	324	2	et	et	PROPN
admet-2626	324	3	al	al	PROPN
admet-2626	324	4	.	.	PUNCT
admet-2626	325	1	[	[	X
admet-2626	325	2	57	57	NUM
admet-2626	325	3	]	]	PUNCT
admet-2626	325	4	reported	report	VERB
admet-2626	325	5	a	a	DET
admet-2626	325	6	measured	measured	ADJ
admet-2626	325	7	value	value	NOUN
admet-2626	325	8	of	of	ADP
admet-2626	325	9	sw	sw	PROPN
admet-2626	325	10	of	of	ADP
admet-2626	325	11	lysine	lysine	NOUN
admet-2626	325	12	which	which	PRON
admet-2626	325	13	is	be	AUX
admet-2626	325	14	in	in	ADP
admet-2626	325	15	good	good	ADJ
admet-2626	325	16	agreement	agreement	NOUN
admet-2626	325	17	with	with	ADP
admet-2626	325	18	that	that	PRON
admet-2626	325	19	of	of	ADP
admet-2626	325	20	dooley	dooley	NOUN
admet-2626	325	21	and	and	CCONJ
admet-2626	325	22	castellino	castellino	PROPN
admet-2626	325	23	.	.	PUNCT
admet-2626	326	1	however	however	ADV
admet-2626	326	2	,	,	PUNCT
admet-2626	326	3	solubility	solubility	NOUN
admet-2626	326	4	values	value	NOUN
admet-2626	326	5	at	at	ADP
admet-2626	326	6	ph	ph	ADJ
admet-2626	326	7	other	other	ADJ
admet-2626	326	8	than	than	ADP
admet-2626	326	9	phw	phw	NOUN
admet-2626	326	10	were	be	AUX
admet-2626	326	11	not	not	PART
admet-2626	326	12	directly	directly	ADV
admet-2626	326	13	measured	measure	VERB
admet-2626	326	14	.	.	PUNCT
admet-2626	327	1	zhang	zhang	PROPN
admet-2626	327	2	et	et	PROPN
admet-2626	327	3	al	al	PROPN
admet-2626	327	4	.	.	PUNCT
admet-2626	328	1	[	[	X
admet-2626	328	2	57	57	NUM
admet-2626	328	3	]	]	PUNCT
admet-2626	328	4	used	use	VERB
admet-2626	328	5	a	a	DET
admet-2626	328	6	functional	functional	ADJ
admet-2626	328	7	-	-	PUNCT
admet-2626	328	8	group	group	NOUN
admet-2626	328	9	activity	activity	NOUN
admet-2626	328	10	coefficients	coefficient	NOUN
admet-2626	328	11	(	(	PUNCT
admet-2626	328	12	unifac	unifac	NOUN
admet-2626	328	13	)	)	PUNCT
admet-2626	328	14	model	model	NOUN
admet-2626	328	15	to	to	PART
admet-2626	328	16	calculate	calculate	VERB
admet-2626	328	17	the	the	DET
admet-2626	328	18	log	log	NOUN
admet-2626	328	19	s	s	NOUN
admet-2626	328	20	-	-	PUNCT
admet-2626	328	21	ph	ph	ADJ
admet-2626	328	22	profile	profile	NOUN
admet-2626	328	23	.	.	PUNCT
admet-2626	329	1	so	so	ADV
admet-2626	329	2	,	,	PUNCT
admet-2626	329	3	validation	validation	NOUN
admet-2626	329	4	with	with	ADP
admet-2626	329	5	measured	measured	ADJ
admet-2626	329	6	values	value	NOUN
admet-2626	329	7	of	of	ADP
admet-2626	329	8	log	log	NOUN
admet-2626	329	9	s	s	NOUN
admet-2626	329	10	over	over	ADP
admet-2626	329	11	the	the	DET
admet-2626	329	12	ph	ph	ADJ
admet-2626	329	13	range	range	NOUN
admet-2626	329	14	of	of	ADP
admet-2626	329	15	interest	interest	NOUN
admet-2626	329	16	would	would	AUX
admet-2626	329	17	be	be	AUX
admet-2626	329	18	a	a	DET
admet-2626	329	19	welcome	welcome	ADJ
admet-2626	329	20	contribution	contribution	NOUN
admet-2626	329	21	.	.	PUNCT
admet-2626	330	1	conclusion	conclusion	NOUN
admet-2626	330	2	published	publish	VERB
admet-2626	330	3	values	value	NOUN
admet-2626	330	4	of	of	ADP
admet-2626	330	5	neutral	neutral	ADJ
admet-2626	330	6	drug	drug	NOUN
admet-2626	330	7	solubility	solubility	NOUN
admet-2626	330	8	in	in	ADP
admet-2626	330	9	pure	pure	ADJ
admet-2626	330	10	water	water	NOUN
admet-2626	330	11	,	,	PUNCT
admet-2626	330	12	sw	sw	PROPN
admet-2626	330	13	,	,	PUNCT
admet-2626	330	14	can	can	AUX
admet-2626	330	15	be	be	AUX
admet-2626	330	16	quite	quite	ADV
admet-2626	330	17	useful	useful	ADJ
admet-2626	330	18	for	for	ADP
admet-2626	330	19	ranking	rank	VERB
admet-2626	330	20	research	research	NOUN
admet-2626	330	21	compounds	compound	NOUN
admet-2626	330	22	according	accord	VERB
admet-2626	330	23	to	to	ADP
admet-2626	330	24	solubility	solubility	NOUN
admet-2626	330	25	.	.	PUNCT
admet-2626	331	1	all	all	ADV
admet-2626	331	2	too	too	ADV
admet-2626	331	3	often	often	ADV
admet-2626	331	4	,	,	PUNCT
admet-2626	331	5	the	the	DET
admet-2626	331	6	published	publish	VERB
admet-2626	331	7	assay	assay	NOUN
admet-2626	331	8	details	detail	NOUN
admet-2626	331	9	are	be	AUX
admet-2626	331	10	sparsely	sparsely	ADV
admet-2626	331	11	specified	specify	VERB
admet-2626	331	12	,	,	PUNCT
admet-2626	331	13	making	make	VERB
admet-2626	331	14	quality	quality	NOUN
admet-2626	331	15	assessment	assessment	NOUN
admet-2626	331	16	of	of	ADP
admet-2626	331	17	the	the	DET
admet-2626	331	18	reported	report	VERB
admet-2626	331	19	solubility	solubility	NOUN
admet-2626	331	20	challenging	challenging	ADJ
admet-2626	331	21	.	.	PUNCT
admet-2626	332	1	so	so	ADV
admet-2626	332	2	,	,	PUNCT
admet-2626	332	3	from	from	ADP
admet-2626	332	4	a	a	DET
admet-2626	332	5	solution	solution	NOUN
admet-2626	332	6	chemistry	chemistry	NOUN
admet-2626	332	7	mechanistic	mechanistic	ADJ
admet-2626	332	8	point	point	NOUN
admet-2626	332	9	of	of	ADP
admet-2626	332	10	view	view	NOUN
admet-2626	332	11	,	,	PUNCT
admet-2626	332	12	the	the	DET
admet-2626	332	13	application	application	NOUN
admet-2626	332	14	of	of	ADP
admet-2626	332	15	sw	sw	PROPN
admet-2626	332	16	can	can	AUX
admet-2626	332	17	be	be	AUX
admet-2626	332	18	problematic	problematic	ADJ
admet-2626	332	19	.	.	PUNCT
admet-2626	333	1	for	for	ADP
admet-2626	333	2	newly	newly	ADV
admet-2626	333	3	-	-	PUNCT
admet-2626	333	4	approved	approve	VERB
admet-2626	333	5	drugs	drug	NOUN
admet-2626	333	6	,	,	PUNCT
admet-2626	333	7	usually	usually	ADV
admet-2626	333	8	,	,	PUNCT
admet-2626	333	9	only	only	ADV
admet-2626	333	10	simple	simple	ADJ
admet-2626	333	11	water	water	NOUN
admet-2626	333	12	solubilities	solubility	NOUN
admet-2626	333	13	are	be	AUX
admet-2626	333	14	publicly	publicly	ADV
admet-2626	333	15	available	available	ADJ
admet-2626	333	16	,	,	PUNCT
admet-2626	333	17	as	as	SCONJ
admet-2626	333	18	gleaned	glean	VERB
admet-2626	333	19	from	from	ADP
admet-2626	333	20	nda	nda	PROPN
admet-2626	333	21	filings	filing	NOUN
admet-2626	333	22	and/or	and/or	CCONJ
admet-2626	333	23	patents	patent	NOUN
admet-2626	333	24	.	.	PUNCT
admet-2626	334	1	however	however	ADV
admet-2626	334	2	,	,	PUNCT
admet-2626	334	3	there	there	PRON
admet-2626	334	4	are	be	VERB
admet-2626	334	5	opportunities	opportunity	NOUN
admet-2626	334	6	to	to	PART
admet-2626	334	7	extract	extract	VERB
admet-2626	334	8	potentially	potentially	ADV
admet-2626	334	9	useful	useful	ADJ
admet-2626	334	10	additional	additional	ADJ
admet-2626	334	11	information	information	NOUN
admet-2626	334	12	from	from	ADP
admet-2626	334	13	such	such	ADJ
admet-2626	334	14	measurements	measurement	NOUN
admet-2626	334	15	.	.	PUNCT
admet-2626	335	1	for	for	ADP
admet-2626	335	2	example	example	NOUN
admet-2626	335	3	,	,	PUNCT
admet-2626	335	4	the	the	DET
admet-2626	335	5	reliability	reliability	NOUN
admet-2626	335	6	of	of	ADP
admet-2626	335	7	the	the	DET
admet-2626	335	8	measured	measure	VERB
admet-2626	335	9	sw	sw	PROPN
admet-2626	335	10	would	would	AUX
admet-2626	335	11	be	be	AUX
admet-2626	335	12	confirmed	confirm	VERB
admet-2626	335	13	if	if	SCONJ
admet-2626	335	14	the	the	DET
admet-2626	335	15	corresponding	correspond	VERB
admet-2626	335	16	phw	phw	NOUN
admet-2626	335	17	of	of	ADP
admet-2626	335	18	the	the	DET
admet-2626	335	19	saturated	saturate	VERB
admet-2626	335	20	solutions	solution	NOUN
admet-2626	335	21	were	be	AUX
admet-2626	335	22	measured	measure	VERB
admet-2626	335	23	and	and	CCONJ
admet-2626	335	24	reported	report	VERB
admet-2626	335	25	.	.	PUNCT
admet-2626	336	1	perhaps	perhaps	ADV
admet-2626	336	2	the	the	DET
admet-2626	336	3	reporting	reporting	NOUN
admet-2626	336	4	of	of	ADP
admet-2626	336	5	measured	measure	VERB
admet-2626	336	6	phw	phw	NOUN
admet-2626	336	7	will	will	AUX
admet-2626	336	8	be	be	AUX
admet-2626	336	9	more	more	ADV
admet-2626	336	10	common	common	ADJ
admet-2626	336	11	,	,	PUNCT
admet-2626	336	12	as	as	SCONJ
admet-2626	336	13	improved	improve	VERB
admet-2626	336	14	understanding	understanding	NOUN
admet-2626	336	15	of	of	ADP
admet-2626	336	16	the	the	DET
admet-2626	336	17	broader	broad	ADJ
admet-2626	336	18	applicability	applicability	NOUN
admet-2626	336	19	of	of	ADP
admet-2626	336	20	sw	sw	PROPN
admet-2626	336	21	is	be	AUX
admet-2626	336	22	recognized	recognize	VERB
admet-2626	336	23	more	more	ADV
admet-2626	336	24	widely	widely	ADV
admet-2626	336	25	.	.	PUNCT
admet-2626	337	1	this	this	DET
admet-2626	337	2	commentary	commentary	NOUN
admet-2626	337	3	describes	describe	VERB
admet-2626	337	4	known	know	VERB
admet-2626	337	5	but	but	CCONJ
admet-2626	337	6	often	often	ADV
admet-2626	337	7	neglected	neglect	VERB
admet-2626	337	8	steps	step	NOUN
admet-2626	337	9	which	which	PRON
admet-2626	337	10	could	could	AUX
admet-2626	337	11	be	be	AUX
admet-2626	337	12	taken	take	VERB
admet-2626	337	13	,	,	PUNCT
admet-2626	337	14	based	base	VERB
admet-2626	337	15	on	on	ADP
admet-2626	337	16	rigorous	rigorous	ADJ
admet-2626	337	17	activity	activity	NOUN
admet-2626	337	18	corrections	correction	NOUN
admet-2626	337	19	,	,	PUNCT
admet-2626	337	20	to	to	PART
admet-2626	337	21	draw	draw	VERB
admet-2626	337	22	out	out	ADP
admet-2626	337	23	valuable	valuable	ADJ
admet-2626	337	24	information	information	NOUN
admet-2626	337	25	about	about	ADP
admet-2626	337	26	the	the	DET
admet-2626	337	27	solubility	solubility	NOUN
admet-2626	337	28	of	of	ADP
admet-2626	337	29	druglike	druglike	ADJ
admet-2626	337	30	substances	substance	NOUN
admet-2626	337	31	as	as	ADP
admet-2626	337	32	a	a	DET
admet-2626	337	33	function	function	NOUN
admet-2626	337	34	of	of	ADP
admet-2626	337	35	ph	ph	ADJ
admet-2626	337	36	and	and	CCONJ
admet-2626	337	37	ionic	ionic	ADJ
admet-2626	337	38	strength	strength	NOUN
admet-2626	337	39	when	when	SCONJ
admet-2626	337	40	only	only	ADV
admet-2626	337	41	a	a	DET
admet-2626	337	42	single	single	ADJ
admet-2626	337	43	-	-	PUNCT
admet-2626	337	44	point	point	NOUN
admet-2626	337	45	sw	sw	NOUN
admet-2626	337	46	is	be	AUX
admet-2626	337	47	reported	report	VERB
admet-2626	337	48	.	.	PUNCT
admet-2626	338	1	examples	example	NOUN
admet-2626	338	2	employing	employ	VERB
admet-2626	338	3	thirty	thirty	NUM
admet-2626	338	4	-	-	PUNCT
admet-2626	338	5	two	two	NUM
admet-2626	338	6	critically	critically	ADV
admet-2626	338	7	selected	select	VERB
admet-2626	338	8	weakly	weakly	ADJ
admet-2626	338	9	-	-	PUNCT
admet-2626	338	10	ionizable	ionizable	ADJ
admet-2626	338	11	molecules	molecule	NOUN
admet-2626	338	12	form	form	VERB
admet-2626	338	13	the	the	DET
admet-2626	338	14	springboard	springboard	NOUN
admet-2626	338	15	for	for	ADP
admet-2626	338	16	the	the	DET
admet-2626	338	17	methods	method	NOUN
admet-2626	338	18	reviewed	review	VERB
admet-2626	338	19	.	.	PUNCT
admet-2626	339	1	when	when	SCONJ
admet-2626	339	2	a	a	DET
admet-2626	339	3	weakly	weakly	ADJ
admet-2626	339	4	ionizable	ionizable	ADJ
admet-2626	339	5	molecule	molecule	NOUN
admet-2626	339	6	in	in	ADP
admet-2626	339	7	neutral	neutral	ADJ
admet-2626	339	8	form	form	NOUN
admet-2626	339	9	is	be	AUX
admet-2626	339	10	added	add	VERB
admet-2626	339	11	to	to	ADP
admet-2626	339	12	pure	pure	ADJ
admet-2626	339	13	water	water	NOUN
admet-2626	339	14	in	in	ADP
admet-2626	339	15	sufficient	sufficient	ADJ
admet-2626	339	16	amount	amount	NOUN
admet-2626	339	17	to	to	PART
admet-2626	339	18	form	form	VERB
admet-2626	339	19	a	a	DET
admet-2626	339	20	saturated	saturate	VERB
admet-2626	339	21	solution	solution	NOUN
admet-2626	339	22	,	,	PUNCT
admet-2626	339	23	the	the	DET
admet-2626	339	24	equilibrium	equilibrium	NOUN
admet-2626	339	25	ph	ph	NOUN
admet-2626	339	26	is	be	AUX
admet-2626	339	27	reached	reach	VERB
admet-2626	339	28	at	at	ADP
admet-2626	339	29	phw	phw	NOUN
admet-2626	339	30	.	.	PUNCT
admet-2626	340	1	the	the	DET
admet-2626	340	2	ionic	ionic	ADJ
admet-2626	340	3	strength	strength	NOUN
admet-2626	340	4	,	,	PUNCT
admet-2626	340	5	iw	iw	INTJ
admet-2626	340	6	,	,	PUNCT
admet-2626	340	7	is	be	AUX
admet-2626	340	8	close	close	ADJ
admet-2626	340	9	to	to	ADP
admet-2626	340	10	zero	zero	NUM
admet-2626	340	11	at	at	ADP
admet-2626	340	12	that	that	DET
admet-2626	340	13	ph	ph	NOUN
admet-2626	340	14	,	,	PUNCT
admet-2626	340	15	unless	unless	SCONJ
admet-2626	340	16	the	the	DET
admet-2626	340	17	molecule	molecule	NOUN
admet-2626	340	18	is	be	AUX
admet-2626	340	19	very	very	ADV
admet-2626	340	20	soluble	soluble	ADJ
admet-2626	340	21	and/or	and/or	CCONJ
admet-2626	340	22	is	be	AUX
admet-2626	340	23	polyprotic	polyprotic	ADJ
admet-2626	340	24	.	.	PUNCT
admet-2626	341	1	also	also	ADV
admet-2626	341	2	,	,	PUNCT
admet-2626	341	3	the	the	DET
admet-2626	341	4	buffer	buffer	NOUN
admet-2626	341	5	capacity	capacity	NOUN
admet-2626	341	6	is	be	AUX
admet-2626	341	7	often	often	ADV
admet-2626	341	8	at	at	ADP
admet-2626	341	9	a	a	DET
admet-2626	341	10	local	local	ADJ
admet-2626	341	11	minimum	minimum	NOUN
admet-2626	341	12	at	at	ADP
admet-2626	341	13	phw	phw	NOUN
admet-2626	341	14	(	(	PUNCT
admet-2626	341	15	barely	barely	ADV
admet-2626	341	16	so	so	ADV
admet-2626	341	17	in	in	ADP
admet-2626	341	18	the	the	DET
admet-2626	341	19	interesting	interesting	ADJ
admet-2626	341	20	case	case	NOUN
admet-2626	341	21	of	of	ADP
admet-2626	341	22	lysine	lysine	NOUN
admet-2626	341	23	)	)	PUNCT
admet-2626	341	24	.	.	PUNCT
admet-2626	342	1	if	if	SCONJ
admet-2626	342	2	a	a	DET
admet-2626	342	3	strong	strong	ADJ
admet-2626	342	4	acid	acid	NOUN
admet-2626	342	5	/	/	SYM
admet-2626	342	6	base	base	NOUN
admet-2626	342	7	is	be	AUX
admet-2626	342	8	used	use	VERB
admet-2626	342	9	to	to	PART
admet-2626	342	10	adjust	adjust	VERB
admet-2626	342	11	the	the	DET
admet-2626	342	12	ph	ph	NOUN
admet-2626	342	13	away	away	ADV
admet-2626	342	14	from	from	ADP
admet-2626	342	15	phw	phw	NOUN
admet-2626	342	16	,	,	PUNCT
admet-2626	342	17	the	the	DET
admet-2626	342	18	ionic	ionic	ADJ
admet-2626	342	19	strength	strength	NOUN
admet-2626	342	20	increases	increase	NOUN
admet-2626	342	21	,	,	PUNCT
admet-2626	342	22	substantially	substantially	ADV
admet-2626	342	23	in	in	ADP
admet-2626	342	24	some	some	DET
admet-2626	342	25	cases	case	NOUN
admet-2626	342	26	(	(	PUNCT
admet-2626	342	27	e.g.	e.g.	ADV
admet-2626	342	28	with	with	ADP
admet-2626	342	29	lysine	lysine	NOUN
admet-2626	342	30	,	,	PUNCT
admet-2626	342	31	i	i	PRON
admet-2626	342	32	>	>	X
admet-2626	342	33	10	10	NUM
admet-2626	342	34	m	m	NOUN
admet-2626	342	35	at	at	ADP
admet-2626	342	36	ph	ph	PROPN
admet-2626	342	37	7.4	7.4	NUM
admet-2626	342	38	)	)	PUNCT
admet-2626	342	39	.	.	PUNCT
admet-2626	343	1	the	the	DET
admet-2626	343	2	physiologically	physiologically	ADV
admet-2626	343	3	relevant	relevant	ADJ
admet-2626	343	4	ionic	ionic	ADJ
admet-2626	343	5	strength	strength	NOUN
admet-2626	343	6	is	be	AUX
admet-2626	343	7	close	close	ADJ
admet-2626	343	8	to	to	ADP
admet-2626	343	9	0.15	0.15	NUM
admet-2626	343	10	m.	m.	NOUN
admet-2626	343	11	to	to	PART
admet-2626	343	12	address	address	VERB
admet-2626	343	13	the	the	DET
admet-2626	343	14	effects	effect	NOUN
admet-2626	343	15	of	of	ADP
admet-2626	343	16	shifts	shift	NOUN
admet-2626	343	17	in	in	ADP
admet-2626	343	18	ionic	ionic	ADJ
admet-2626	343	19	strengths	strength	NOUN
admet-2626	343	20	,	,	PUNCT
admet-2626	343	21	a	a	DET
admet-2626	343	22	rigorous	rigorous	ADJ
admet-2626	343	23	method	method	NOUN
admet-2626	343	24	incorporating	incorporate	VERB
admet-2626	343	25	activity	activity	NOUN
admet-2626	343	26	coefficients	coefficient	NOUN
admet-2626	343	27	into	into	ADP
admet-2626	343	28	the	the	DET
admet-2626	343	29	equilibrium	equilibrium	NOUN
admet-2626	343	30	constants	constant	NOUN
admet-2626	343	31	based	base	VERB
admet-2626	343	32	on	on	ADP
admet-2626	343	33	the	the	DET
admet-2626	343	34	admet	admet	PROPN
admet-2626	343	35	&	&	CCONJ
admet-2626	343	36	dmpk	dmpk	PROPN
admet-2626	343	37	13(1	13(1	NUM
admet-2626	343	38	)	)	PUNCT
admet-2626	343	39	(	(	PUNCT
admet-2626	343	40	2025	2025	NUM
admet-2626	343	41	)	)	PUNCT
admet-2626	343	42	2626	2626	NUM
admet-2626	343	43	transforming	transform	VERB
admet-2626	343	44	drug	drug	NOUN
admet-2626	343	45	solubility	solubility	NOUN
admet-2626	343	46	measurement	measurement	NOUN
admet-2626	343	47	doi	doi	PROPN
admet-2626	343	48	:	:	PUNCT
admet-2626	343	49	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	343	50	13	13	NUM
admet-2626	343	51	stokes	stokes	PROPN
admet-2626	343	52	-	-	PUNCT
admet-2626	343	53	robinson	robinson	PROPN
admet-2626	343	54	hydration	hydration	NOUN
admet-2626	343	55	theory	theory	NOUN
admet-2626	343	56	is	be	AUX
admet-2626	343	57	discussed	discuss	VERB
admet-2626	343	58	at	at	ADP
admet-2626	343	59	length	length	NOUN
admet-2626	343	60	in	in	ADP
admet-2626	343	61	appendix	appendix	NOUN
admet-2626	343	62	a	a	PRON
admet-2626	343	63	,	,	PUNCT
admet-2626	343	64	with	with	ADP
admet-2626	343	65	explicit	explicit	ADJ
admet-2626	343	66	examples	example	NOUN
admet-2626	343	67	given	give	VERB
admet-2626	343	68	in	in	ADP
admet-2626	343	69	the	the	DET
admet-2626	343	70	main	main	ADJ
admet-2626	343	71	text	text	NOUN
admet-2626	343	72	of	of	ADP
admet-2626	343	73	the	the	DET
admet-2626	343	74	commentary	commentary	NOUN
admet-2626	343	75	.	.	PUNCT
admet-2626	344	1	this	this	PRON
admet-2626	344	2	includes	include	VERB
admet-2626	344	3	using	use	VERB
admet-2626	344	4	estimated	estimate	VERB
admet-2626	344	5	‘	'	PUNCT
admet-2626	344	6	salting	salt	VERB
admet-2626	344	7	-	-	PUNCT
admet-2626	344	8	out	out	ADP
admet-2626	344	9	’	'	PUNCT
admet-2626	344	10	constants	constant	NOUN
admet-2626	344	11	to	to	PART
admet-2626	344	12	adjust	adjust	VERB
admet-2626	344	13	activity	activity	NOUN
admet-2626	344	14	coefficients	coefficient	NOUN
admet-2626	344	15	of	of	ADP
admet-2626	344	16	neutral	neutral	ADJ
admet-2626	344	17	species	specie	NOUN
admet-2626	344	18	.	.	PUNCT
admet-2626	345	1	in	in	ADP
admet-2626	345	2	cases	case	NOUN
admet-2626	345	3	where	where	SCONJ
admet-2626	345	4	experimental	experimental	ADJ
admet-2626	345	5	phw	phw	NOUN
admet-2626	345	6	values	value	NOUN
admet-2626	345	7	are	be	AUX
admet-2626	345	8	not	not	PART
admet-2626	345	9	reported	report	VERB
admet-2626	345	10	(	(	PUNCT
admet-2626	345	11	or	or	CCONJ
admet-2626	345	12	even	even	ADV
admet-2626	345	13	measured	measure	VERB
admet-2626	345	14	)	)	PUNCT
admet-2626	345	15	,	,	PUNCT
admet-2626	345	16	a	a	DET
admet-2626	345	17	completely	completely	ADV
admet-2626	345	18	general	general	ADJ
admet-2626	345	19	computational	computational	ADJ
admet-2626	345	20	method	method	NOUN
admet-2626	345	21	for	for	ADP
admet-2626	345	22	determining	determine	VERB
admet-2626	345	23	the	the	DET
admet-2626	345	24	water	water	NOUN
admet-2626	345	25	phw	phw	NOUN
admet-2626	345	26	for	for	ADP
admet-2626	345	27	saturated	saturate	VERB
admet-2626	345	28	solutions	solution	NOUN
admet-2626	345	29	of	of	ADP
admet-2626	345	30	neutral	neutral	ADJ
admet-2626	345	31	drugs	drug	NOUN
admet-2626	345	32	is	be	AUX
admet-2626	345	33	described	describe	VERB
admet-2626	345	34	here	here	ADV
admet-2626	345	35	(	(	PUNCT
admet-2626	345	36	assuming	assume	VERB
admet-2626	345	37	impurity	impurity	NOUN
admet-2626	345	38	-	-	PUNCT
admet-2626	345	39	free	free	ADJ
admet-2626	345	40	suspensions	suspension	NOUN
admet-2626	345	41	)	)	PUNCT
admet-2626	345	42	.	.	PUNCT
admet-2626	346	1	for	for	ADP
admet-2626	346	2	monoprotic	monoprotic	ADJ
admet-2626	346	3	molecules	molecule	NOUN
admet-2626	346	4	,	,	PUNCT
admet-2626	346	5	simple	simple	ADJ
admet-2626	346	6	explicit	explicit	ADJ
admet-2626	346	7	equations	equation	NOUN
admet-2626	346	8	are	be	AUX
admet-2626	346	9	presented	present	VERB
admet-2626	346	10	in	in	ADP
admet-2626	346	11	appendix	appendix	ADJ
admet-2626	346	12	c.	c.	NOUN
admet-2626	346	13	for	for	ADP
admet-2626	346	14	diprotic	diprotic	ADJ
admet-2626	346	15	acids	acid	NOUN
admet-2626	346	16	and	and	CCONJ
admet-2626	346	17	bases	basis	NOUN
admet-2626	346	18	,	,	PUNCT
admet-2626	346	19	polynomial	polynomial	ADJ
admet-2626	346	20	equations	equation	NOUN
admet-2626	346	21	in	in	ADP
admet-2626	346	22	[	[	X
admet-2626	346	23	h+	h+	X
admet-2626	346	24	]	]	X
admet-2626	346	25	taken	take	VERB
admet-2626	346	26	to	to	ADP
admet-2626	346	27	the	the	DET
admet-2626	346	28	power	power	NOUN
admet-2626	346	29	of	of	ADP
admet-2626	346	30	three	three	NUM
admet-2626	346	31	are	be	AUX
admet-2626	346	32	derived	derive	VERB
admet-2626	346	33	.	.	PUNCT
admet-2626	347	1	the	the	DET
admet-2626	347	2	latter	latter	ADJ
admet-2626	347	3	can	can	AUX
admet-2626	347	4	be	be	AUX
admet-2626	347	5	solved	solve	VERB
admet-2626	347	6	using	use	VERB
admet-2626	347	7	a	a	DET
admet-2626	347	8	simple	simple	ADJ
admet-2626	347	9	spreadsheet	spreadsheet	NOUN
admet-2626	347	10	method	method	NOUN
admet-2626	347	11	[	[	X
admet-2626	347	12	52	52	NUM
admet-2626	347	13	]	]	PUNCT
admet-2626	347	14	.	.	PUNCT
admet-2626	348	1	apparently	apparently	ADV
admet-2626	348	2	,	,	PUNCT
admet-2626	348	3	for	for	ADP
admet-2626	348	4	triprotic	triprotic	ADJ
admet-2626	348	5	and	and	CCONJ
admet-2626	348	6	higher	high	ADJ
admet-2626	348	7	order	order	NOUN
admet-2626	348	8	molecules	molecule	NOUN
admet-2626	348	9	,	,	PUNCT
admet-2626	348	10	explicit	explicit	ADJ
admet-2626	348	11	equations	equation	NOUN
admet-2626	348	12	have	have	AUX
admet-2626	348	13	not	not	PART
admet-2626	348	14	been	be	AUX
admet-2626	348	15	described	describe	VERB
admet-2626	348	16	in	in	ADP
admet-2626	348	17	the	the	DET
admet-2626	348	18	literature	literature	NOUN
admet-2626	348	19	.	.	PUNCT
admet-2626	349	1	the	the	DET
admet-2626	349	2	pdisol	pdisol	ADJ
admet-2626	349	3	-	-	PUNCT
admet-2626	349	4	x	x	NOUN
admet-2626	349	5	program	program	NOUN
admet-2626	349	6	does	do	AUX
admet-2626	349	7	not	not	PART
admet-2626	349	8	rely	rely	VERB
admet-2626	349	9	on	on	ADP
admet-2626	349	10	the	the	DET
admet-2626	349	11	explicit	explicit	ADJ
admet-2626	349	12	equations	equation	NOUN
admet-2626	349	13	listed	list	VERB
admet-2626	349	14	in	in	ADP
admet-2626	349	15	the	the	DET
admet-2626	349	16	appendix	appendix	NOUN
admet-2626	349	17	and	and	CCONJ
admet-2626	349	18	elsewhere	elsewhere	ADV
admet-2626	349	19	[	[	X
admet-2626	349	20	12	12	NUM
admet-2626	349	21	]	]	PUNCT
admet-2626	349	22	but	but	CCONJ
admet-2626	349	23	rather	rather	ADV
admet-2626	349	24	develops	develop	VERB
admet-2626	349	25	internal	internal	ADJ
admet-2626	349	26	implicit	implicit	ADJ
admet-2626	349	27	mass	mass	ADJ
admet-2626	349	28	action	action	NOUN
admet-2626	349	29	equilibrium	equilibrium	NOUN
admet-2626	349	30	casting	cast	VERB
admet-2626	349	31	to	to	PART
admet-2626	349	32	calculate	calculate	VERB
admet-2626	349	33	phw	phw	NOUN
admet-2626	349	34	.	.	PUNCT
admet-2626	350	1	nevertheless	nevertheless	ADV
admet-2626	350	2	,	,	PUNCT
admet-2626	350	3	the	the	DET
admet-2626	350	4	explicit	explicit	ADJ
admet-2626	350	5	equations	equation	NOUN
admet-2626	350	6	can	can	AUX
admet-2626	350	7	be	be	AUX
admet-2626	350	8	useful	useful	ADJ
admet-2626	350	9	for	for	ADP
admet-2626	350	10	checking	check	VERB
admet-2626	350	11	the	the	DET
admet-2626	350	12	pdisol	pdisol	ADJ
admet-2626	350	13	-	-	PUNCT
admet-2626	350	14	x	x	NOUN
admet-2626	350	15	calculation	calculation	NOUN
admet-2626	350	16	results	result	VERB
admet-2626	350	17	for	for	ADP
admet-2626	350	18	the	the	DET
admet-2626	350	19	simpler	simple	ADJ
admet-2626	350	20	monoand	monoand	NOUN
admet-2626	350	21	diprotic	diprotic	ADJ
admet-2626	350	22	molecules	molecule	NOUN
admet-2626	350	23	.	.	PUNCT
admet-2626	351	1	analytic	analytic	ADJ
admet-2626	351	2	continuation	continuation	NOUN
admet-2626	351	3	is	be	AUX
admet-2626	351	4	a	a	DET
admet-2626	351	5	mathematical	mathematical	ADJ
admet-2626	351	6	procedure	procedure	NOUN
admet-2626	351	7	,	,	PUNCT
admet-2626	351	8	where	where	SCONJ
admet-2626	351	9	given	give	VERB
admet-2626	351	10	all	all	DET
admet-2626	351	11	the	the	DET
admet-2626	351	12	relevant	relevant	ADJ
admet-2626	351	13	equilibrium	equilibrium	NOUN
admet-2626	351	14	constants	constant	NOUN
admet-2626	351	15	and	and	CCONJ
admet-2626	351	16	total	total	ADJ
admet-2626	351	17	concentrations	concentration	NOUN
admet-2626	351	18	,	,	PUNCT
admet-2626	351	19	the	the	DET
admet-2626	351	20	entire	entire	ADJ
admet-2626	351	21	solubility	solubility	NOUN
admet-2626	351	22	profile	profile	NOUN
admet-2626	351	23	can	can	AUX
admet-2626	351	24	be	be	AUX
admet-2626	351	25	simulated	simulate	VERB
admet-2626	351	26	for	for	SCONJ
admet-2626	351	27	a	a	DET
admet-2626	351	28	wide	wide	ADJ
admet-2626	351	29	range	range	NOUN
admet-2626	351	30	of	of	ADP
admet-2626	351	31	ph	ph	NOUN
admet-2626	351	32	.	.	PUNCT
admet-2626	351	33	such	such	ADJ
admet-2626	351	34	log	log	NOUN
admet-2626	351	35	s	s	NOUN
admet-2626	351	36	-	-	PUNCT
admet-2626	351	37	ph	ph	ADJ
admet-2626	351	38	curves	curve	NOUN
admet-2626	351	39	may	may	AUX
admet-2626	351	40	be	be	AUX
admet-2626	351	41	harmonized	harmonize	VERB
admet-2626	351	42	to	to	ADP
admet-2626	351	43	any	any	DET
admet-2626	351	44	practical	practical	ADJ
admet-2626	351	45	level	level	NOUN
admet-2626	351	46	of	of	ADP
admet-2626	351	47	ionic	ionic	ADJ
admet-2626	351	48	strength	strength	NOUN
admet-2626	351	49	,	,	PUNCT
admet-2626	351	50	well	well	ADV
admet-2626	351	51	above	above	ADP
admet-2626	351	52	the	the	DET
admet-2626	351	53	near	near	ADJ
admet-2626	351	54	zero	zero	NUM
admet-2626	351	55	values	value	NOUN
admet-2626	351	56	characteristic	characteristic	ADJ
admet-2626	351	57	of	of	ADP
admet-2626	351	58	the	the	DET
admet-2626	351	59	measurements	measurement	NOUN
admet-2626	351	60	of	of	ADP
admet-2626	351	61	sw	sw	PROPN
admet-2626	351	62	.	.	PUNCT
admet-2626	352	1	since	since	SCONJ
admet-2626	352	2	activity	activity	NOUN
admet-2626	352	3	coefficients	coefficient	NOUN
admet-2626	352	4	depend	depend	VERB
admet-2626	352	5	on	on	ADP
admet-2626	352	6	the	the	DET
admet-2626	352	7	differences	difference	NOUN
admet-2626	352	8	between	between	ADP
admet-2626	352	9	the	the	DET
admet-2626	352	10	low	low	ADJ
admet-2626	352	11	ionic	ionic	ADJ
admet-2626	352	12	strength	strength	NOUN
admet-2626	352	13	in	in	ADP
admet-2626	352	14	the	the	DET
admet-2626	352	15	measurement	measurement	NOUN
admet-2626	352	16	and	and	CCONJ
admet-2626	352	17	the	the	DET
admet-2626	352	18	elevated	elevated	ADJ
admet-2626	352	19	physiologically	physiologically	ADV
admet-2626	352	20	-	-	PUNCT
admet-2626	352	21	relevant	relevant	ADJ
admet-2626	352	22	reference	reference	NOUN
admet-2626	352	23	level	level	NOUN
admet-2626	352	24	,	,	PUNCT
admet-2626	352	25	the	the	DET
admet-2626	352	26	shape	shape	NOUN
admet-2626	352	27	of	of	ADP
admet-2626	352	28	the	the	DET
admet-2626	352	29	log	log	NOUN
admet-2626	352	30	s	s	NOUN
admet-2626	352	31	-	-	PUNCT
admet-2626	352	32	ph	ph	ADJ
admet-2626	352	33	curve	curve	NOUN
admet-2626	352	34	generated	generate	VERB
admet-2626	352	35	by	by	ADP
admet-2626	352	36	analytic	analytic	ADJ
admet-2626	352	37	continuation	continuation	NOUN
admet-2626	352	38	can	can	AUX
admet-2626	352	39	be	be	AUX
admet-2626	352	40	distorted	distort	VERB
admet-2626	352	41	,	,	PUNCT
admet-2626	352	42	compared	compare	VERB
admet-2626	352	43	to	to	ADP
admet-2626	352	44	the	the	DET
admet-2626	352	45	hyperbolic	hyperbolic	ADJ
admet-2626	352	46	shaped	shape	VERB
admet-2626	352	47	curve	curve	NOUN
admet-2626	352	48	generated	generate	VERB
admet-2626	352	49	by	by	ADP
admet-2626	352	50	the	the	DET
admet-2626	352	51	benchmark	benchmark	PROPN
admet-2626	352	52	henderson	henderson	PROPN
admet-2626	352	53	-	-	PUNCT
admet-2626	352	54	hasselbalch	hasselbalch	PROPN
admet-2626	352	55	equation	equation	NOUN
admet-2626	352	56	.	.	PUNCT
admet-2626	353	1	acetaminophen	acetaminophen	NOUN
admet-2626	353	2	is	be	AUX
admet-2626	353	3	an	an	DET
admet-2626	353	4	example	example	NOUN
admet-2626	353	5	of	of	ADP
admet-2626	353	6	a	a	DET
admet-2626	353	7	small	small	ADJ
admet-2626	353	8	‘	'	PUNCT
admet-2626	353	9	rotated	rotated	ADJ
admet-2626	353	10	sigmoidal	sigmoidal	NOUN
admet-2626	353	11	’	'	PUNCT
admet-2626	353	12	shape	shape	NOUN
admet-2626	353	13	distortion	distortion	NOUN
admet-2626	353	14	(	(	PUNCT
admet-2626	353	15	solid	solid	ADJ
admet-2626	353	16	green	green	ADJ
admet-2626	353	17	curve	curve	NOUN
admet-2626	353	18	,	,	PUNCT
admet-2626	353	19	fig	fig	NOUN
admet-2626	353	20	.	.	PUNCT
admet-2626	354	1	1c	1c	NOUN
admet-2626	354	2	)	)	PUNCT
admet-2626	354	3	.	.	PUNCT
admet-2626	355	1	in	in	ADP
admet-2626	355	2	the	the	DET
admet-2626	355	3	cases	case	NOUN
admet-2626	355	4	of	of	ADP
admet-2626	355	5	benzene	benzene	NOUN
admet-2626	355	6	trito	trito	PROPN
admet-2626	355	7	hexacarboxylic	hexacarboxylic	PROPN
admet-2626	355	8	acid	acid	NOUN
admet-2626	355	9	derivatives	derivative	NOUN
admet-2626	355	10	(	(	PUNCT
admet-2626	355	11	fig	fig	NOUN
admet-2626	355	12	.	.	PUNCT
admet-2626	355	13	2d	2d	NOUN
admet-2626	355	14	,	,	PUNCT
admet-2626	355	15	2f	2f	NOUN
admet-2626	355	16	,	,	PUNCT
admet-2626	355	17	2	2	NUM
admet-2626	355	18	g	g	NOUN
admet-2626	355	19	and	and	CCONJ
admet-2626	355	20	2h	2h	NUM
admet-2626	355	21	)	)	PUNCT
admet-2626	355	22	and	and	CCONJ
admet-2626	355	23	lysine	lysine	NOUN
admet-2626	355	24	(	(	PUNCT
admet-2626	355	25	fig	fig	NOUN
admet-2626	355	26	.	.	PUNCT
admet-2626	355	27	4c	4c	NOUN
admet-2626	355	28	)	)	PUNCT
admet-2626	355	29	,	,	PUNCT
admet-2626	355	30	distortions	distortion	NOUN
admet-2626	355	31	of	of	ADP
admet-2626	355	32	the	the	DET
admet-2626	355	33	solubility	solubility	NOUN
admet-2626	355	34	-	-	PUNCT
admet-2626	355	35	ph	ph	NOUN
admet-2626	355	36	curves	curve	NOUN
admet-2626	355	37	generated	generate	VERB
admet-2626	355	38	by	by	ADP
admet-2626	355	39	analytic	analytic	ADJ
admet-2626	355	40	continuation	continuation	NOUN
admet-2626	355	41	take	take	VERB
admet-2626	355	42	on	on	ADP
admet-2626	355	43	forms	form	NOUN
admet-2626	355	44	which	which	PRON
admet-2626	355	45	show	show	VERB
admet-2626	355	46	considerable	considerable	ADJ
admet-2626	355	47	departure	departure	NOUN
admet-2626	355	48	from	from	ADP
admet-2626	355	49	those	those	PRON
admet-2626	355	50	indicated	indicate	VERB
admet-2626	355	51	by	by	ADP
admet-2626	355	52	the	the	DET
admet-2626	355	53	hendersonhasselbalch	hendersonhasselbalch	PROPN
admet-2626	355	54	equation	equation	NOUN
admet-2626	355	55	.	.	PUNCT
admet-2626	356	1	this	this	PRON
admet-2626	356	2	is	be	AUX
admet-2626	356	3	a	a	DET
admet-2626	356	4	novel	novel	ADJ
admet-2626	356	5	prediction	prediction	NOUN
admet-2626	356	6	,	,	PUNCT
admet-2626	356	7	which	which	PRON
admet-2626	356	8	still	still	ADV
admet-2626	356	9	needs	need	VERB
admet-2626	356	10	to	to	PART
admet-2626	356	11	be	be	AUX
admet-2626	356	12	experimentally	experimentally	ADV
admet-2626	356	13	validated	validate	VERB
admet-2626	356	14	by	by	ADP
admet-2626	356	15	solubility	solubility	NOUN
admet-2626	356	16	measurements	measurement	NOUN
admet-2626	356	17	at	at	ADP
admet-2626	356	18	ph	ph	ADJ
admet-2626	356	19	values	value	NOUN
admet-2626	356	20	apart	apart	ADV
admet-2626	356	21	from	from	ADP
admet-2626	356	22	phw	phw	NOUN
admet-2626	356	23	.	.	PUNCT
admet-2626	357	1	a	a	DET
admet-2626	357	2	partial	partial	ADJ
admet-2626	357	3	test	test	NOUN
admet-2626	357	4	of	of	ADP
admet-2626	357	5	the	the	DET
admet-2626	357	6	effectiveness	effectiveness	NOUN
admet-2626	357	7	of	of	ADP
admet-2626	357	8	the	the	DET
admet-2626	357	9	srht	srht	NOUN
admet-2626	357	10	model	model	NOUN
admet-2626	357	11	can	can	AUX
admet-2626	357	12	be	be	AUX
admet-2626	357	13	made	make	VERB
admet-2626	357	14	by	by	ADP
admet-2626	357	15	directly	directly	ADV
admet-2626	357	16	determining	determine	VERB
admet-2626	357	17	the	the	DET
admet-2626	357	18	activity	activity	NOUN
admet-2626	357	19	coefficients	coefficient	NOUN
admet-2626	357	20	of	of	ADP
admet-2626	357	21	hydrogen	hydrogen	NOUN
admet-2626	357	22	ions	ion	NOUN
admet-2626	357	23	using	use	VERB
admet-2626	357	24	the	the	DET
admet-2626	357	25	approach	approach	NOUN
admet-2626	357	26	in	in	ADP
admet-2626	357	27	appendix	appendix	PROPN
admet-2626	357	28	b.	b.	PROPN
admet-2626	357	29	also	also	ADV
admet-2626	357	30	,	,	PUNCT
admet-2626	357	31	selecting	select	VERB
admet-2626	357	32	compounds	compound	NOUN
admet-2626	357	33	whose	whose	DET
admet-2626	357	34	pka	pka	PROPN
admet-2626	357	35	values	value	NOUN
admet-2626	357	36	are	be	AUX
admet-2626	357	37	reliably	reliably	ADV
admet-2626	357	38	known	know	VERB
admet-2626	357	39	as	as	ADP
admet-2626	357	40	a	a	DET
admet-2626	357	41	function	function	NOUN
admet-2626	357	42	of	of	ADP
admet-2626	357	43	ionic	ionic	ADJ
admet-2626	357	44	strength	strength	NOUN
admet-2626	357	45	(	(	PUNCT
admet-2626	357	46	e.g.	e.g.	ADV
admet-2626	357	47	phthalic	phthalic	ADJ
admet-2626	357	48	acid	acid	NOUN
admet-2626	357	49	)	)	PUNCT
admet-2626	357	50	could	could	AUX
admet-2626	357	51	be	be	AUX
admet-2626	357	52	used	use	VERB
admet-2626	357	53	to	to	PART
admet-2626	357	54	compare	compare	VERB
admet-2626	357	55	the	the	DET
admet-2626	357	56	predicted	predict	VERB
admet-2626	357	57	shifts	shift	NOUN
admet-2626	357	58	in	in	ADP
admet-2626	357	59	pka	pka	PROPN
admet-2626	357	60	values	value	NOUN
admet-2626	357	61	based	base	VERB
admet-2626	357	62	on	on	ADP
admet-2626	357	63	the	the	DET
admet-2626	357	64	srht	srht	NOUN
admet-2626	357	65	model	model	NOUN
admet-2626	357	66	to	to	ADP
admet-2626	357	67	those	those	PRON
admet-2626	357	68	extracted	extract	VERB
admet-2626	357	69	from	from	ADP
admet-2626	357	70	known	known	ADJ
admet-2626	357	71	pka	pka	PROPN
admet-2626	357	72	values	value	NOUN
admet-2626	357	73	.	.	PUNCT
admet-2626	358	1	it	it	PRON
admet-2626	358	2	would	would	AUX
admet-2626	358	3	be	be	AUX
admet-2626	358	4	an	an	DET
admet-2626	358	5	ongoing	ongoing	ADJ
admet-2626	358	6	process	process	NOUN
admet-2626	358	7	of	of	ADP
admet-2626	358	8	refining	refine	VERB
admet-2626	358	9	the	the	DET
admet-2626	358	10	srht	srht	NOUN
admet-2626	358	11	model	model	NOUN
admet-2626	358	12	,	,	PUNCT
admet-2626	358	13	to	to	PART
admet-2626	358	14	improve	improve	VERB
admet-2626	358	15	its	its	PRON
admet-2626	358	16	effectiveness	effectiveness	NOUN
admet-2626	358	17	.	.	PUNCT
admet-2626	359	1	it	it	PRON
admet-2626	359	2	is	be	AUX
admet-2626	359	3	stressed	stress	VERB
admet-2626	359	4	that	that	SCONJ
admet-2626	359	5	transforming	transform	VERB
admet-2626	359	6	measured	measure	VERB
admet-2626	359	7	drug	drug	NOUN
admet-2626	359	8	solubility	solubility	NOUN
admet-2626	359	9	in	in	ADP
admet-2626	359	10	water	water	NOUN
admet-2626	359	11	to	to	ADP
admet-2626	359	12	physiologically	physiologically	ADV
admet-2626	359	13	-	-	PUNCT
admet-2626	359	14	appropriate	appropriate	ADJ
admet-2626	359	15	solubilityph	solubilityph	NOUN
admet-2626	359	16	would	would	AUX
admet-2626	359	17	better	well	ADV
admet-2626	359	18	match	match	VERB
admet-2626	359	19	the	the	DET
admet-2626	359	20	conditions	condition	NOUN
admet-2626	359	21	found	find	VERB
admet-2626	359	22	in	in	ADP
admet-2626	359	23	biological	biological	ADJ
admet-2626	359	24	media	medium	NOUN
admet-2626	359	25	,	,	PUNCT
admet-2626	359	26	potentially	potentially	ADV
admet-2626	359	27	improving	improve	VERB
admet-2626	359	28	applications	application	NOUN
admet-2626	359	29	of	of	ADP
admet-2626	359	30	solubility	solubility	NOUN
admet-2626	359	31	in	in	ADP
admet-2626	359	32	pharmaceutical	pharmaceutical	ADJ
admet-2626	359	33	research	research	NOUN
admet-2626	359	34	and	and	CCONJ
admet-2626	359	35	development	development	NOUN
admet-2626	359	36	.	.	PUNCT
admet-2626	360	1	supplementary	supplementary	ADJ
admet-2626	360	2	material	material	NOUN
admet-2626	360	3	additional	additional	ADJ
admet-2626	360	4	data	datum	NOUN
admet-2626	360	5	are	be	AUX
admet-2626	360	6	available	available	ADJ
admet-2626	360	7	at	at	ADP
admet-2626	360	8	https://pub.iapchem.org/ojs/index.php/admet/article/view/2626	https://pub.iapchem.org/ojs/index.php/admet/article/view/2626	NUM
admet-2626	360	9	,	,	PUNCT
admet-2626	360	10	or	or	CCONJ
admet-2626	360	11	from	from	ADP
admet-2626	360	12	the	the	DET
admet-2626	360	13	corresponding	corresponding	ADJ
admet-2626	360	14	author	author	NOUN
admet-2626	360	15	on	on	ADP
admet-2626	360	16	request	request	NOUN
admet-2626	360	17	.	.	PUNCT
admet-2626	361	1	notes	note	NOUN
admet-2626	361	2	:	:	PUNCT
admet-2626	361	3	the	the	DET
admet-2626	361	4	author	author	NOUN
admet-2626	361	5	declares	declare	VERB
admet-2626	361	6	no	no	DET
admet-2626	361	7	competing	compete	VERB
admet-2626	361	8	financial	financial	ADJ
admet-2626	361	9	interest	interest	NOUN
admet-2626	361	10	.	.	PUNCT
admet-2626	362	1	funding	funding	NOUN
admet-2626	362	2	:	:	PUNCT
admet-2626	362	3	no	no	DET
admet-2626	362	4	funding	funding	NOUN
admet-2626	362	5	was	be	AUX
admet-2626	362	6	received	receive	VERB
admet-2626	362	7	for	for	ADP
admet-2626	362	8	this	this	DET
admet-2626	362	9	commentary	commentary	NOUN
admet-2626	362	10	.	.	PUNCT
admet-2626	363	1	acknowledgments	acknowledgment	NOUN
admet-2626	363	2	:	:	PUNCT
admet-2626	363	3	gratitude	gratitude	NOUN
admet-2626	363	4	is	be	AUX
admet-2626	363	5	expressed	express	VERB
admet-2626	363	6	to	to	ADP
admet-2626	363	7	dr	dr	PROPN
admet-2626	363	8	.	.	PROPN
admet-2626	363	9	manfred	manfred	PROPN
admet-2626	363	10	kansy	kansy	PROPN
admet-2626	363	11	and	and	CCONJ
admet-2626	363	12	prof	prof	PROPN
admet-2626	363	13	.	.	PUNCT
admet-2626	364	1	joyce	joyce	PROPN
admet-2626	364	2	saltalamachia	saltalamachia	VERB
admet-2626	364	3	for	for	ADP
admet-2626	364	4	critically	critically	ADV
admet-2626	364	5	reading	read	VERB
admet-2626	364	6	parts	part	NOUN
admet-2626	364	7	of	of	ADP
admet-2626	364	8	the	the	DET
admet-2626	364	9	manuscript	manuscript	NOUN
admet-2626	364	10	and	and	CCONJ
admet-2626	364	11	offering	offer	VERB
admet-2626	364	12	helpful	helpful	ADJ
admet-2626	364	13	suggestions	suggestion	NOUN
admet-2626	364	14	to	to	PART
admet-2626	364	15	improve	improve	VERB
admet-2626	364	16	clarity	clarity	NOUN
admet-2626	364	17	and	and	CCONJ
admet-2626	364	18	impact	impact	NOUN
admet-2626	364	19	.	.	PUNCT
admet-2626	365	1	this	this	DET
admet-2626	365	2	commentary	commentary	NOUN
admet-2626	365	3	is	be	AUX
admet-2626	365	4	dedicated	dedicate	VERB
admet-2626	365	5	to	to	ADP
admet-2626	365	6	the	the	DET
admet-2626	365	7	memory	memory	NOUN
admet-2626	365	8	of	of	ADP
admet-2626	365	9	prof	prof	PROPN
admet-2626	365	10	.	.	PUNCT
admet-2626	366	1	michael	michael	PROPN
admet-2626	366	2	h.	h.	PROPN
admet-2626	366	3	abraham	abraham	PROPN
admet-2626	366	4	.	.	PUNCT
admet-2626	367	1	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	367	2	https://pub.iapchem.org/ojs/index.php/admet/article/view/2626	https://pub.iapchem.org/ojs/index.php/admet/article/view/2626	PROPN
admet-2626	367	3	a.	a.	NOUN
admet-2626	367	4	avdeef	avdeef	PROPN
admet-2626	367	5	admet	admet	PROPN
admet-2626	367	6	&	&	CCONJ
admet-2626	367	7	dmpk	dmpk	PROPN
admet-2626	367	8	13(1	13(1	NUM
admet-2626	367	9	)	)	PUNCT
admet-2626	367	10	(	(	PUNCT
admet-2626	367	11	2025	2025	NUM
admet-2626	367	12	)	)	PUNCT
admet-2626	367	13	2626	2626	NUM
admet-2626	367	14	14	14	NUM
admet-2626	367	15	references	reference	NOUN
admet-2626	367	16	[	[	X
admet-2626	367	17	1	1	NUM
admet-2626	367	18	]	]	PUNCT
admet-2626	367	19	a.	a.	NOUN
admet-2626	367	20	avdeef	avdeef	PROPN
admet-2626	367	21	,	,	PUNCT
admet-2626	367	22	m.	m.	PROPN
admet-2626	367	23	kansy	kansy	PROPN
admet-2626	367	24	.	.	PUNCT
admet-2626	368	1	predicting	predict	VERB
admet-2626	368	2	solubility	solubility	NOUN
admet-2626	368	3	of	of	ADP
admet-2626	368	4	newly	newly	ADV
admet-2626	368	5	-	-	PUNCT
admet-2626	368	6	approved	approve	VERB
admet-2626	368	7	drugs	drug	NOUN
admet-2626	368	8	(	(	PUNCT
admet-2626	368	9	2016	2016	NUM
admet-2626	368	10	-	-	SYM
admet-2626	368	11	2020	2020	NUM
admet-2626	368	12	)	)	PUNCT
admet-2626	368	13	with	with	ADP
admet-2626	368	14	a	a	DET
admet-2626	368	15	simple	simple	ADJ
admet-2626	368	16	absolv	absolv	NOUN
admet-2626	368	17	and	and	CCONJ
admet-2626	368	18	gse(flexible	gse(flexible	ADJ
admet-2626	368	19	-	-	PUNCT
admet-2626	368	20	acceptor	acceptor	NOUN
admet-2626	368	21	)	)	PUNCT
admet-2626	368	22	consensus	consensus	NOUN
admet-2626	368	23	model	model	NOUN
admet-2626	368	24	outperforming	outperform	VERB
admet-2626	368	25	random	random	ADJ
admet-2626	368	26	forest	forest	NOUN
admet-2626	368	27	regression	regression	NOUN
admet-2626	368	28	.	.	PUNCT
admet-2626	369	1	journal	journal	NOUN
admet-2626	369	2	of	of	ADP
admet-2626	369	3	solution	solution	NOUN
admet-2626	369	4	chemistry	chemistry	NOUN
admet-2626	369	5	51	51	NUM
admet-2626	369	6	(	(	PUNCT
admet-2626	369	7	2022	2022	NUM
admet-2626	369	8	)	)	PUNCT
admet-2626	369	9	1020	1020	NUM
admet-2626	369	10	-	-	SYM
admet-2626	369	11	1055	1055	NUM
admet-2626	369	12	.	.	PUNCT
admet-2626	370	1	https://doi.org/10.1007/s10953-022-01141-7	https://doi.org/10.1007/s10953-022-01141-7	NUM
admet-2626	371	1	[	[	X
admet-2626	371	2	2	2	NUM
admet-2626	371	3	]	]	PUNCT
admet-2626	371	4	a.	a.	NOUN
admet-2626	371	5	avdeef	avdeef	PROPN
admet-2626	371	6	,	,	PUNCT
admet-2626	371	7	m.	m.	PROPN
admet-2626	371	8	kansy	kansy	PROPN
admet-2626	371	9	.	.	PUNCT
admet-2626	372	1	trends	trend	NOUN
admet-2626	372	2	in	in	ADP
admet-2626	372	3	physchem	physchem	NOUN
admet-2626	372	4	properties	property	NOUN
admet-2626	372	5	of	of	ADP
admet-2626	372	6	newly	newly	ADV
admet-2626	372	7	approved	approve	VERB
admet-2626	372	8	drugs	drug	NOUN
admet-2626	372	9	over	over	ADP
admet-2626	372	10	the	the	DET
admet-2626	372	11	last	last	ADJ
admet-2626	372	12	six	six	NUM
admet-2626	372	13	years	year	NOUN
admet-2626	372	14	,	,	PUNCT
admet-2626	372	15	predicting	predict	VERB
admet-2626	372	16	solubility	solubility	NOUN
admet-2626	372	17	of	of	ADP
admet-2626	372	18	drugs	drug	NOUN
admet-2626	372	19	approved	approve	VERB
admet-2626	372	20	in	in	ADP
admet-2626	372	21	2021	2021	NUM
admet-2626	372	22	.	.	PUNCT
admet-2626	373	1	journal	journal	NOUN
admet-2626	373	2	of	of	ADP
admet-2626	373	3	solution	solution	NOUN
admet-2626	373	4	chemistry	chemistry	NOUN
admet-2626	373	5	51	51	NUM
admet-2626	373	6	(	(	PUNCT
admet-2626	373	7	2022	2022	NUM
admet-2626	373	8	)	)	PUNCT
admet-2626	373	9	1455	1455	NUM
admet-2626	373	10	-	-	SYM
admet-2626	373	11	1481	1481	NUM
admet-2626	373	12	.	.	PUNCT
admet-2626	374	1	https://doi.org/10.1007/s10953-022-01199-3	https://doi.org/10.1007/s10953-022-01199-3	NOUN
admet-2626	375	1	[	[	X
admet-2626	375	2	3	3	NUM
admet-2626	375	3	]	]	PUNCT
admet-2626	375	4	a.	a.	NOUN
admet-2626	375	5	avdeef	avdeef	PROPN
admet-2626	375	6	.	.	PUNCT
admet-2626	376	1	predicting	predict	VERB
admet-2626	376	2	solubility	solubility	NOUN
admet-2626	376	3	of	of	ADP
admet-2626	376	4	new	new	ADJ
admet-2626	376	5	drugs	drug	NOUN
admet-2626	376	6	handbook	handbook	NOUN
admet-2626	376	7	of	of	ADP
admet-2626	376	8	critically	critically	ADV
admet-2626	376	9	curated	curate	VERB
admet-2626	376	10	data	datum	NOUN
admet-2626	376	11	for	for	ADP
admet-2626	376	12	pharmaceutical	pharmaceutical	ADJ
admet-2626	376	13	research	research	NOUN
admet-2626	376	14	.	.	PUNCT
admet-2626	377	1	crc	crc	PROPN
admet-2626	377	2	press	press	PROPN
admet-2626	377	3	,	,	PUNCT
admet-2626	377	4	boca	boca	PROPN
admet-2626	377	5	raton	raton	PROPN
admet-2626	377	6	,	,	PUNCT
admet-2626	377	7	fl	fl	PROPN
admet-2626	377	8	,	,	PUNCT
admet-2626	377	9	usa	usa	PROPN
admet-2626	377	10	,	,	PUNCT
admet-2626	377	11	2024	2024	NUM
admet-2626	377	12	.	.	PUNCT
admet-2626	378	1	isbn	isbn	ADJ
admet-2626	378	2	:	:	PUNCT
admet-2626	378	3	978	978	NUM
admet-2626	378	4	-	-	SYM
admet-2626	378	5	1032617671	1032617671	NUM
admet-2626	378	6	.	.	PUNCT
admet-2626	379	1	[	[	X
admet-2626	379	2	4	4	NUM
admet-2626	379	3	]	]	PUNCT
admet-2626	379	4	a.	a.	NOUN
admet-2626	379	5	avdeef	avdeef	PROPN
admet-2626	379	6	.	.	PUNCT
admet-2626	380	1	suggested	suggest	VERB
admet-2626	380	2	improvements	improvement	NOUN
admet-2626	380	3	for	for	ADP
admet-2626	380	4	measurement	measurement	NOUN
admet-2626	380	5	of	of	ADP
admet-2626	380	6	equilibrium	equilibrium	NOUN
admet-2626	380	7	solubility	solubility	NOUN
admet-2626	380	8	-	-	PUNCT
admet-2626	380	9	ph	ph	NOUN
admet-2626	380	10	of	of	ADP
admet-2626	380	11	ionizable	ionizable	ADJ
admet-2626	380	12	drugs	drug	NOUN
admet-2626	380	13	.	.	PUNCT
admet-2626	381	1	admet	admet	PROPN
admet-2626	381	2	&	&	CCONJ
admet-2626	381	3	dmpk	dmpk	PROPN
admet-2626	381	4	3	3	NUM
admet-2626	381	5	(	(	PUNCT
admet-2626	381	6	2015	2015	NUM
admet-2626	381	7	)	)	PUNCT
admet-2626	381	8	84	84	NUM
admet-2626	381	9	-	-	SYM
admet-2626	381	10	109	109	NUM
admet-2626	381	11	.	.	PUNCT
admet-2626	381	12	https://doi.org/10.5599/admet.3.2.193	https://doi.org/10.5599/admet.3.2.193	PROPN
admet-2626	382	1	[	[	X
admet-2626	382	2	5	5	NUM
admet-2626	382	3	]	]	PUNCT
admet-2626	382	4	a.	a.	NOUN
admet-2626	382	5	avdeef	avdeef	PROPN
admet-2626	382	6	,	,	PUNCT
admet-2626	382	7	e.	e.	PROPN
admet-2626	382	8	fuguet	fuguet	PROPN
admet-2626	382	9	,	,	PUNCT
admet-2626	382	10	a.	a.	PROPN
admet-2626	382	11	llinàs	llinàs	PROPN
admet-2626	382	12	,	,	PUNCT
admet-2626	382	13	c.	c.	PROPN
admet-2626	382	14	ràfols	ràfols	PROPN
admet-2626	382	15	,	,	PUNCT
admet-2626	382	16	e.	e.	PROPN
admet-2626	382	17	bosch	bosch	PROPN
admet-2626	382	18	,	,	PUNCT
admet-2626	382	19	g.	g.	PROPN
admet-2626	382	20	völgyi	völgyi	PROPN
admet-2626	382	21	,	,	PUNCT
admet-2626	382	22	t.	t.	NOUN
admet-2626	382	23	verbić	verbić	PROPN
admet-2626	382	24	,	,	PUNCT
admet-2626	382	25	e.	e.	PROPN
admet-2626	382	26	boldyreva	boldyreva	PROPN
admet-2626	382	27	,	,	PUNCT
admet-2626	382	28	k.	k.	PROPN
admet-2626	382	29	takács	takács	PROPN
admet-2626	382	30	-	-	PUNCT
admet-2626	382	31	novák	novák	PROPN
admet-2626	382	32	.	.	PUNCT
admet-2626	383	1	equilibrium	equilibrium	NOUN
admet-2626	383	2	solubility	solubility	NOUN
admet-2626	383	3	measurement	measurement	NOUN
admet-2626	383	4	of	of	ADP
admet-2626	383	5	ionizable	ionizable	ADJ
admet-2626	383	6	drugs	drug	NOUN
admet-2626	383	7	consensus	consensus	NOUN
admet-2626	383	8	recommendations	recommendation	NOUN
admet-2626	383	9	for	for	ADP
admet-2626	383	10	improving	improve	VERB
admet-2626	383	11	data	datum	NOUN
admet-2626	383	12	quality	quality	NOUN
admet-2626	383	13	.	.	PUNCT
admet-2626	384	1	admet	admet	PROPN
admet-2626	384	2	&	&	CCONJ
admet-2626	384	3	dmpk	dmpk	PROPN
admet-2626	384	4	4	4	NUM
admet-2626	384	5	(	(	PUNCT
admet-2626	384	6	2016	2016	NUM
admet-2626	384	7	)	)	PUNCT
admet-2626	384	8	117	117	NUM
admet-2626	384	9	-	-	SYM
admet-2626	384	10	178	178	NUM
admet-2626	384	11	.	.	PUNCT
admet-2626	385	1	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-2626	385	2	[	[	X
admet-2626	385	3	6	6	NUM
admet-2626	385	4	]	]	PUNCT
admet-2626	385	5	a.	a.	NOUN
admet-2626	385	6	ono	ono	PROPN
admet-2626	385	7	,	,	PUNCT
admet-2626	385	8	n.	n.	PROPN
admet-2626	385	9	matsumura	matsumura	ADV
admet-2626	385	10	,	,	PUNCT
admet-2626	385	11	t.	t.	PROPN
admet-2626	385	12	kimoto	kimoto	PROPN
admet-2626	385	13	,	,	PUNCT
admet-2626	385	14	y.	y.	PROPN
admet-2626	385	15	akiyama	akiyama	PROPN
admet-2626	385	16	,	,	PUNCT
admet-2626	385	17	s.	s.	PROPN
admet-2626	385	18	funaki	funaki	PROPN
admet-2626	385	19	,	,	PUNCT
admet-2626	385	20	n.	n.	PROPN
admet-2626	385	21	tamura	tamura	PROPN
admet-2626	385	22	,	,	PUNCT
admet-2626	385	23	s.	s.	PROPN
admet-2626	385	24	hayashi	hayashi	PROPN
admet-2626	385	25	,	,	PUNCT
admet-2626	385	26	y.	y.	PROPN
admet-2626	385	27	kojima	kojima	PROPN
admet-2626	385	28	,	,	PUNCT
admet-2626	385	29	m.	m.	NOUN
admet-2626	385	30	fushimi	fushimi	PROPN
admet-2626	385	31	,	,	PUNCT
admet-2626	385	32	h.	h.	PROPN
admet-2626	385	33	sudaki	sudaki	PROPN
admet-2626	385	34	,	,	PUNCT
admet-2626	385	35	r.	r.	PROPN
admet-2626	385	36	aihara	aihara	PROPN
admet-2626	385	37	,	,	PUNCT
admet-2626	385	38	y.	y.	PROPN
admet-2626	385	39	haruna	haruna	PROPN
admet-2626	385	40	,	,	PUNCT
admet-2626	385	41	m.	m.	NOUN
admet-2626	385	42	jiko	jiko	PROPN
admet-2626	385	43	,	,	PUNCT
admet-2626	385	44	m.	m.	NOUN
admet-2626	385	45	iwasaki	iwasaki	PROPN
admet-2626	385	46	,	,	PUNCT
admet-2626	385	47	t.	t.	PROPN
admet-2626	385	48	fujita	fujita	PROPN
admet-2626	385	49	,	,	PUNCT
admet-2626	385	50	k.	k.	PROPN
admet-2626	385	51	sugano	sugano	PROPN
admet-2626	385	52	.	.	PUNCT
admet-2626	386	1	harmonizing	harmonize	VERB
admet-2626	386	2	solubility	solubility	NOUN
admet-2626	386	3	measurement	measurement	NOUN
admet-2626	386	4	to	to	PART
admet-2626	386	5	lower	lower	VERB
admet-2626	386	6	inter	inter	ADJ
admet-2626	386	7	-	-	ADJ
admet-2626	386	8	laboratory	laboratory	ADJ
admet-2626	386	9	variance	variance	NOUN
admet-2626	386	10	progress	progress	NOUN
admet-2626	386	11	of	of	ADP
admet-2626	386	12	consortium	consortium	NOUN
admet-2626	386	13	of	of	ADP
admet-2626	386	14	biopharmaceutical	biopharmaceutical	ADJ
admet-2626	386	15	tools	tool	NOUN
admet-2626	386	16	(	(	PUNCT
admet-2626	386	17	cobito	cobito	ADJ
admet-2626	386	18	)	)	PUNCT
admet-2626	386	19	in	in	ADP
admet-2626	386	20	japan	japan	PROPN
admet-2626	386	21	.	.	PUNCT
admet-2626	387	1	admet	admet	PROPN
admet-2626	387	2	&	&	CCONJ
admet-2626	387	3	dmpk	dmpk	PROPN
admet-2626	387	4	7	7	NUM
admet-2626	387	5	(	(	PUNCT
admet-2626	387	6	2019	2019	NUM
admet-2626	387	7	)	)	PUNCT
admet-2626	387	8	183	183	NUM
admet-2626	387	9	-	-	SYM
admet-2626	387	10	195	195	NUM
admet-2626	387	11	.	.	PUNCT
admet-2626	387	12	https://doi.org/	https://doi.org/	PROPN
admet-2626	387	13	10.5599	10.5599	NUM
admet-2626	387	14	/	/	SYM
admet-2626	387	15	admet.704	admet.704	NOUN
admet-2626	387	16	[	[	X
admet-2626	387	17	7	7	NUM
admet-2626	387	18	]	]	X
admet-2626	387	19	m.	m.	NOUN
admet-2626	387	20	vertzoni	vertzoni	PROPN
admet-2626	387	21	,	,	PUNCT
admet-2626	387	22	j.	j.	PROPN
admet-2626	387	23	alsenz	alsenz	PROPN
admet-2626	387	24	,	,	PUNCT
admet-2626	387	25	p.	p.	NOUN
admet-2626	387	26	augustijns	augustijns	NOUN
admet-2626	387	27	,	,	PUNCT
admet-2626	387	28	a.	a.	PROPN
admet-2626	387	29	bauer	bauer	PROPN
admet-2626	387	30	-	-	PUNCT
admet-2626	387	31	brandl	brandl	PROPN
admet-2626	387	32	,	,	PUNCT
admet-2626	387	33	c.a.s	c.a.	VERB
admet-2626	387	34	.	.	PROPN
admet-2626	387	35	bergström	bergström	PROPN
admet-2626	387	36	,	,	PUNCT
admet-2626	387	37	j.	j.	PROPN
admet-2626	387	38	brouwers	brouwers	PROPN
admet-2626	387	39	,	,	PUNCT
admet-2626	387	40	a.	a.	NOUN
admet-2626	387	41	müllerz	müllerz	PROPN
admet-2626	387	42	,	,	PUNCT
admet-2626	387	43	g.	g.	PROPN
admet-2626	387	44	perlovich	perlovich	PROPN
admet-2626	387	45	,	,	PUNCT
admet-2626	387	46	c.	c.	PROPN
admet-2626	387	47	saal	saal	PROPN
admet-2626	387	48	,	,	PUNCT
admet-2626	387	49	k.	k.	PROPN
admet-2626	387	50	sugano	sugano	PROPN
admet-2626	387	51	,	,	PUNCT
admet-2626	387	52	c.	c.	PROPN
admet-2626	387	53	reppas	reppas	PROPN
admet-2626	387	54	.	.	PUNCT
admet-2626	388	1	ungap	ungap	NOUN
admet-2626	388	2	best	good	ADJ
admet-2626	388	3	practice	practice	NOUN
admet-2626	388	4	for	for	ADP
admet-2626	388	5	improving	improve	VERB
admet-2626	388	6	solubility	solubility	NOUN
admet-2626	388	7	data	datum	NOUN
admet-2626	388	8	quality	quality	NOUN
admet-2626	388	9	of	of	ADP
admet-2626	388	10	orally	orally	ADV
admet-2626	388	11	administered	administer	VERB
admet-2626	388	12	drugs	drug	NOUN
admet-2626	388	13	.	.	PUNCT
admet-2626	389	1	european	european	ADJ
admet-2626	389	2	journal	journal	PROPN
admet-2626	389	3	of	of	ADP
admet-2626	389	4	pharmaceutical	pharmaceutical	PROPN
admet-2626	389	5	sciences	science	NOUN
admet-2626	389	6	168	168	NUM
admet-2626	389	7	(	(	PUNCT
admet-2626	389	8	2022	2022	NUM
admet-2626	389	9	)	)	PUNCT
admet-2626	389	10	106043	106043	NUM
admet-2626	389	11	.	.	PUNCT
admet-2626	390	1	https://doi.org/10.1016/j.ejps.2021.106043	https://doi.org/10.1016/j.ejps.2021.106043	NOUN
admet-2626	390	2	[	[	X
admet-2626	390	3	8	8	NUM
admet-2626	390	4	]	]	X
admet-2626	390	5	d.	d.	PROPN
admet-2626	390	6	j.	j.	PROPN
admet-2626	390	7	w.	w.	PROPN
admet-2626	390	8	grant	grant	PROPN
admet-2626	390	9	,	,	PUNCT
admet-2626	390	10	t.	t.	PROPN
admet-2626	390	11	higuchi	higuchi	PROPN
admet-2626	390	12	.	.	PUNCT
admet-2626	391	1	solubility	solubility	NOUN
admet-2626	391	2	behavior	behavior	NOUN
admet-2626	391	3	of	of	ADP
admet-2626	391	4	organic	organic	ADJ
admet-2626	391	5	compounds	compound	NOUN
admet-2626	391	6	,	,	PUNCT
admet-2626	391	7	wiley	wiley	NOUN
admet-2626	391	8	-	-	PUNCT
admet-2626	391	9	interscience	interscience	NOUN
admet-2626	391	10	:	:	PUNCT
admet-2626	391	11	new	new	PROPN
admet-2626	391	12	york	york	PROPN
admet-2626	391	13	,	,	PUNCT
admet-2626	391	14	1990	1990	NUM
admet-2626	391	15	.	.	PUNCT
admet-2626	392	1	isbn:0471613142	isbn:0471613142	X
admet-2626	392	2	.	.	PUNCT
admet-2626	393	1	[	[	X
admet-2626	393	2	9	9	NUM
admet-2626	393	3	]	]	PUNCT
admet-2626	393	4	a.	a.	NOUN
admet-2626	393	5	avdeef	avdeef	PROPN
admet-2626	393	6	,	,	PUNCT
admet-2626	393	7	j.j	j.j	PROPN
admet-2626	393	8	.	.	PROPN
admet-2626	393	9	bucher	bucher	PROPN
admet-2626	393	10	.	.	PUNCT
admet-2626	394	1	accurate	accurate	ADJ
admet-2626	394	2	measurements	measurement	NOUN
admet-2626	394	3	of	of	ADP
admet-2626	394	4	the	the	DET
admet-2626	394	5	concentration	concentration	NOUN
admet-2626	394	6	of	of	ADP
admet-2626	394	7	hydrogen	hydrogen	NOUN
admet-2626	394	8	ions	ion	NOUN
admet-2626	394	9	with	with	ADP
admet-2626	394	10	a	a	DET
admet-2626	394	11	glass	glass	NOUN
admet-2626	394	12	electrode	electrode	NOUN
admet-2626	394	13	:	:	PUNCT
admet-2626	394	14	calibrations	calibration	NOUN
admet-2626	394	15	using	use	VERB
admet-2626	394	16	the	the	DET
admet-2626	394	17	prideaux	prideaux	ADJ
admet-2626	394	18	and	and	CCONJ
admet-2626	394	19	other	other	ADJ
admet-2626	394	20	universal	universal	ADJ
admet-2626	394	21	buffer	buffer	NOUN
admet-2626	394	22	solutions	solution	NOUN
admet-2626	394	23	and	and	CCONJ
admet-2626	394	24	a	a	DET
admet-2626	394	25	computercontrolled	computercontrolle	VERB
admet-2626	394	26	automatic	automatic	ADJ
admet-2626	394	27	titrator	titrator	NOUN
admet-2626	394	28	.	.	PUNCT
admet-2626	395	1	analytical	analytical	ADJ
admet-2626	395	2	chemistry	chemistry	NOUN
admet-2626	395	3	50	50	NUM
admet-2626	395	4	(	(	PUNCT
admet-2626	395	5	1978	1978	NUM
admet-2626	395	6	)	)	PUNCT
admet-2626	395	7	2137	2137	NUM
admet-2626	395	8	-	-	SYM
admet-2626	395	9	2142	2142	NUM
admet-2626	395	10	.	.	PUNCT
admet-2626	396	1	https://doi.org/10.1021/ac50036a045	https://doi.org/10.1021/ac50036a045	PROPN
admet-2626	396	2	[	[	X
admet-2626	396	3	10	10	NUM
admet-2626	396	4	]	]	X
admet-2626	396	5	m.h	m.h	PROPN
admet-2626	396	6	.	.	PROPN
admet-2626	396	7	abraham	abraham	PROPN
admet-2626	396	8	,	,	PUNCT
admet-2626	396	9	j.	j.	PROPN
admet-2626	396	10	le	le	PROPN
admet-2626	396	11	.	.	PUNCT
admet-2626	397	1	the	the	DET
admet-2626	397	2	correlation	correlation	NOUN
admet-2626	397	3	and	and	CCONJ
admet-2626	397	4	prediction	prediction	NOUN
admet-2626	397	5	of	of	ADP
admet-2626	397	6	the	the	DET
admet-2626	397	7	solubility	solubility	NOUN
admet-2626	397	8	of	of	ADP
admet-2626	397	9	compounds	compound	NOUN
admet-2626	397	10	in	in	ADP
admet-2626	397	11	water	water	NOUN
admet-2626	397	12	using	use	VERB
admet-2626	397	13	an	an	DET
admet-2626	397	14	amended	amend	VERB
admet-2626	397	15	solvation	solvation	NOUN
admet-2626	397	16	energy	energy	NOUN
admet-2626	397	17	relationship	relationship	NOUN
admet-2626	397	18	.	.	PUNCT
admet-2626	398	1	journal	journal	PROPN
admet-2626	398	2	of	of	ADP
admet-2626	398	3	pharmaceutical	pharmaceutical	NOUN
admet-2626	398	4	sciences	science	NOUN
admet-2626	398	5	88	88	NUM
admet-2626	398	6	(	(	PUNCT
admet-2626	398	7	1999	1999	NUM
admet-2626	398	8	)	)	PUNCT
admet-2626	398	9	868	868	NUM
admet-2626	398	10	-	-	SYM
admet-2626	398	11	880	880	NUM
admet-2626	398	12	.	.	PUNCT
admet-2626	399	1	https://doi.org/10.1021/js9901007	https://doi.org/10.1021/js9901007	X
admet-2626	400	1	[	[	X
admet-2626	400	2	11	11	NUM
admet-2626	400	3	]	]	X
admet-2626	400	4	e.	e.	PROPN
admet-2626	400	5	rytting	rytting	PROPN
admet-2626	400	6	,	,	PUNCT
admet-2626	400	7	k.a	k.a	PROPN
admet-2626	400	8	.	.	PROPN
admet-2626	400	9	lentz	lentz	PROPN
admet-2626	400	10	,	,	PUNCT
admet-2626	400	11	x.q	x.q	PROPN
admet-2626	400	12	.	.	PROPN
admet-2626	400	13	chen	chen	PROPN
admet-2626	400	14	,	,	PUNCT
admet-2626	400	15	f.	f.	PROPN
admet-2626	400	16	qian	qian	PROPN
admet-2626	400	17	,	,	PUNCT
admet-2626	400	18	s.	s.	PROPN
admet-2626	400	19	venkatesh	venkatesh	PROPN
admet-2626	400	20	.	.	PUNCT
admet-2626	401	1	a	a	DET
admet-2626	401	2	quantitative	quantitative	ADJ
admet-2626	401	3	structure	structure	NOUN
admet-2626	401	4	-	-	PUNCT
admet-2626	401	5	property	property	NOUN
admet-2626	401	6	relationship	relationship	NOUN
admet-2626	401	7	for	for	ADP
admet-2626	401	8	predicting	predict	VERB
admet-2626	401	9	drug	drug	NOUN
admet-2626	401	10	solubility	solubility	NOUN
admet-2626	401	11	in	in	ADP
admet-2626	401	12	peg	peg	NOUN
admet-2626	401	13	400	400	NUM
admet-2626	401	14	/	/	SYM
admet-2626	401	15	water	water	NOUN
admet-2626	401	16	cosolvent	cosolvent	NOUN
admet-2626	401	17	systems	system	NOUN
admet-2626	401	18	.	.	PUNCT
admet-2626	402	1	pharmaceutical	pharmaceutical	ADJ
admet-2626	402	2	research	research	NOUN
admet-2626	402	3	21	21	NUM
admet-2626	402	4	(	(	PUNCT
admet-2626	402	5	2004	2004	NUM
admet-2626	402	6	)	)	PUNCT
admet-2626	402	7	237	237	NUM
admet-2626	402	8	-	-	SYM
admet-2626	402	9	244	244	NUM
admet-2626	402	10	.	.	PUNCT
admet-2626	403	1	https://doi.org/10.1023/b:pham.0000016237.06815.7a	https://doi.org/10.1023/b:pham.0000016237.06815.7a	PRON
admet-2626	403	2	[	[	X
admet-2626	403	3	12	12	NUM
admet-2626	403	4	]	]	PUNCT
admet-2626	403	5	a.	a.	NOUN
admet-2626	403	6	avdeef	avdeef	PROPN
admet-2626	403	7	.	.	PUNCT
admet-2626	404	1	absorption	absorption	NOUN
admet-2626	404	2	and	and	CCONJ
admet-2626	404	3	drug	drug	NOUN
admet-2626	404	4	development	development	NOUN
admet-2626	404	5	,	,	PUNCT
admet-2626	404	6	2nd	2nd	ADJ
admet-2626	404	7	ed	ed	NOUN
admet-2626	404	8	.	.	PROPN
admet-2626	404	9	,	,	PUNCT
admet-2626	404	10	wiley	wiley	NOUN
admet-2626	404	11	-	-	PUNCT
admet-2626	404	12	interscience	interscience	PROPN
admet-2626	404	13	,	,	PUNCT
admet-2626	404	14	hoboken	hoboken	PROPN
admet-2626	404	15	nj	nj	PROPN
admet-2626	404	16	,	,	PUNCT
admet-2626	404	17	2012	2012	NUM
admet-2626	404	18	.	.	PUNCT
admet-2626	405	1	isbn	isbn	ADJ
admet-2626	405	2	978	978	NUM
admet-2626	405	3	-	-	SYM
admet-2626	405	4	1	1	NUM
admet-2626	405	5	-	-	PUNCT
admet-2626	405	6	118	118	NUM
admet-2626	405	7	-	-	PUNCT
admet-2626	405	8	05745	05745	NUM
admet-2626	405	9	-	-	SYM
admet-2626	405	10	2	2	NUM
admet-2626	405	11	.	.	PUNCT
admet-2626	405	12	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	PRON
admet-2626	405	13	[	[	X
admet-2626	405	14	13	13	NUM
admet-2626	405	15	]	]	X
admet-2626	405	16	r.h	r.h	PROPN
admet-2626	405	17	.	.	PROPN
admet-2626	405	18	stokes	stokes	PROPN
admet-2626	405	19	,	,	PUNCT
admet-2626	405	20	r.a	r.a	PROPN
admet-2626	405	21	.	.	PROPN
admet-2626	405	22	robinson	robinson	PROPN
admet-2626	405	23	.	.	PROPN
admet-2626	406	1	journal	journal	PROPN
admet-2626	406	2	of	of	ADP
admet-2626	406	3	the	the	DET
admet-2626	406	4	american	american	PROPN
admet-2626	406	5	chemical	chemical	PROPN
admet-2626	406	6	society	society	PROPN
admet-2626	406	7	70	70	NUM
admet-2626	406	8	(	(	PUNCT
admet-2626	406	9	1948	1948	NUM
admet-2626	406	10	)	)	PUNCT
admet-2626	406	11	1870	1870	NUM
admet-2626	406	12	-	-	SYM
admet-2626	406	13	1878	1878	NUM
admet-2626	406	14	.	.	PUNCT
admet-2626	407	1	https://doi.org/10.1021/ja01185a065	https://doi.org/10.1021/ja01185a065	PROPN
admet-2626	407	2	[	[	X
admet-2626	407	3	14	14	NUM
admet-2626	407	4	]	]	PUNCT
admet-2626	407	5	z.	z.	PROPN
admet-2626	407	6	wang	wang	PROPN
admet-2626	407	7	,	,	PUNCT
admet-2626	407	8	l.s	l.s	PROPN
admet-2626	407	9	.	.	PROPN
admet-2626	407	10	burrell	burrell	PROPN
admet-2626	407	11	,	,	PUNCT
admet-2626	407	12	w.j	w.j	PROPN
admet-2626	407	13	.	.	PROPN
admet-2626	407	14	lambert	lambert	PROPN
admet-2626	407	15	.	.	PUNCT
admet-2626	408	1	solubility	solubility	NOUN
admet-2626	408	2	of	of	ADP
admet-2626	408	3	e2050	e2050	PROPN
admet-2626	408	4	at	at	ADP
admet-2626	408	5	various	various	ADJ
admet-2626	408	6	ph	ph	NOUN
admet-2626	408	7	:	:	PUNCT
admet-2626	408	8	a	a	DET
admet-2626	408	9	case	case	NOUN
admet-2626	408	10	in	in	ADP
admet-2626	408	11	which	which	PRON
admet-2626	408	12	apparent	apparent	ADJ
admet-2626	408	13	solubility	solubility	NOUN
admet-2626	408	14	is	be	AUX
admet-2626	408	15	affected	affect	VERB
admet-2626	408	16	by	by	ADP
admet-2626	408	17	the	the	DET
admet-2626	408	18	amount	amount	NOUN
admet-2626	408	19	of	of	ADP
admet-2626	408	20	excess	excess	ADJ
admet-2626	408	21	solid	solid	ADJ
admet-2626	408	22	.	.	PUNCT
admet-2626	409	1	journal	journal	PROPN
admet-2626	409	2	of	of	ADP
admet-2626	409	3	pharmaceutical	pharmaceutical	PROPN
admet-2626	409	4	sciences	science	NOUN
admet-2626	409	5	91	91	NUM
admet-2626	409	6	(	(	PUNCT
admet-2626	409	7	2002	2002	NUM
admet-2626	409	8	)	)	PUNCT
admet-2626	409	9	1445	1445	NUM
admet-2626	409	10	-	-	SYM
admet-2626	409	11	1455	1455	NUM
admet-2626	409	12	.	.	PUNCT
admet-2626	410	1	https://doi.org/10.1002/jps.10107	https://doi.org/10.1002/jps.10107	NOUN
admet-2626	410	2	[	[	X
admet-2626	410	3	15	15	NUM
admet-2626	410	4	]	]	PUNCT
admet-2626	410	5	a.	a.	NOUN
admet-2626	410	6	avdeef	avdeef	PROPN
admet-2626	410	7	.	.	PUNCT
admet-2626	411	1	anomalous	anomalous	ADJ
admet-2626	411	2	salting	salting	NOUN
admet-2626	411	3	-	-	PUNCT
admet-2626	411	4	out	out	NOUN
admet-2626	411	5	,	,	PUNCT
admet-2626	411	6	self	self	NOUN
admet-2626	411	7	-	-	PUNCT
admet-2626	411	8	association	association	NOUN
admet-2626	411	9	and	and	CCONJ
admet-2626	411	10	pka	pka	PROPN
admet-2626	411	11	effects	effect	NOUN
admet-2626	411	12	in	in	ADP
admet-2626	411	13	the	the	DET
admet-2626	411	14	practically	practically	ADV
admet-2626	411	15	-	-	PUNCT
admet-2626	411	16	insoluble	insoluble	ADJ
admet-2626	411	17	bromothymol	bromothymol	PROPN
admet-2626	411	18	blue	blue	NOUN
admet-2626	411	19	.	.	PUNCT
admet-2626	412	1	admet	admet	PROPN
admet-2626	412	2	&	&	CCONJ
admet-2626	412	3	dmpk	dmpk	PROPN
admet-2626	412	4	11	11	NUM
admet-2626	412	5	(	(	PUNCT
admet-2626	412	6	2023	2023	NUM
admet-2626	412	7	)	)	PUNCT
admet-2626	412	8	419	419	NUM
admet-2626	412	9	-	-	SYM
admet-2626	412	10	432	432	NUM
admet-2626	412	11	.	.	PUNCT
admet-2626	413	1	https://doi.org/10.5599/admet.1822	https://doi.org/10.5599/admet.1822	NOUN
admet-2626	413	2	[	[	X
admet-2626	413	3	16	16	NUM
admet-2626	413	4	]	]	PUNCT
admet-2626	413	5	a.	a.	NOUN
admet-2626	413	6	apelblat	apelblat	NOUN
admet-2626	413	7	,	,	PUNCT
admet-2626	413	8	e.	e.	PROPN
admet-2626	413	9	manzurola	manzurola	PROPN
admet-2626	413	10	,	,	PUNCT
admet-2626	413	11	n.a	n.a	PROPN
admet-2626	413	12	.	.	PROPN
admet-2626	413	13	balal	balal	PROPN
admet-2626	413	14	.	.	PUNCT
admet-2626	414	1	the	the	DET
admet-2626	414	2	solubilities	solubility	NOUN
admet-2626	414	3	of	of	ADP
admet-2626	414	4	benzene	benzene	NOUN
admet-2626	414	5	polycarboxylic	polycarboxylic	ADJ
admet-2626	414	6	acids	acid	NOUN
admet-2626	414	7	in	in	ADP
admet-2626	414	8	water	water	NOUN
admet-2626	414	9	.	.	PUNCT
admet-2626	415	1	the	the	DET
admet-2626	415	2	journal	journal	PROPN
admet-2626	415	3	of	of	ADP
admet-2626	415	4	chemical	chemical	PROPN
admet-2626	415	5	thermodynamics	thermodynamic	NOUN
admet-2626	415	6	38	38	NUM
admet-2626	415	7	(	(	PUNCT
admet-2626	415	8	2006	2006	NUM
admet-2626	415	9	)	)	PUNCT
admet-2626	415	10	565	565	NUM
admet-2626	415	11	-	-	SYM
admet-2626	415	12	571	571	NUM
admet-2626	415	13	.	.	PUNCT
admet-2626	416	1	https://doi.org/10.1016/j.jct.2005.07.007	https://doi.org/10.1016/j.jct.2005.07.007	NOUN
admet-2626	416	2	[	[	X
admet-2626	416	3	17	17	NUM
admet-2626	416	4	]	]	X
admet-2626	416	5	m.n	m.n	PROPN
admet-2626	416	6	.	.	PROPN
admet-2626	416	7	alizadeh	alizadeh	PROPN
admet-2626	416	8	,	,	PUNCT
admet-2626	416	9	a.	a.	PROPN
admet-2626	416	10	shayanfar	shayanfar	PROPN
admet-2626	416	11	,	,	PUNCT
admet-2626	416	12	a.	a.	NOUN
admet-2626	416	13	jouyban	jouyban	PROPN
admet-2626	416	14	.	.	PUNCT
admet-2626	417	1	solubilization	solubilization	NOUN
admet-2626	417	2	of	of	ADP
admet-2626	417	3	drugs	drug	NOUN
admet-2626	417	4	using	use	VERB
admet-2626	417	5	sodium	sodium	NOUN
admet-2626	417	6	lauryl	lauryl	NOUN
admet-2626	417	7	sulfate	sulfate	NOUN
admet-2626	417	8	:	:	PUNCT
admet-2626	417	9	experimental	experimental	ADJ
admet-2626	417	10	data	datum	NOUN
admet-2626	417	11	and	and	CCONJ
admet-2626	417	12	modeling	modeling	NOUN
admet-2626	417	13	.	.	PUNCT
admet-2626	418	1	journal	journal	NOUN
admet-2626	418	2	of	of	ADP
admet-2626	418	3	molecular	molecular	ADJ
admet-2626	418	4	liquids	liquid	NOUN
admet-2626	418	5	268	268	NUM
admet-2626	418	6	(	(	PUNCT
admet-2626	418	7	2018	2018	NUM
admet-2626	418	8	)	)	PUNCT
admet-2626	418	9	410	410	NUM
admet-2626	418	10	-	-	SYM
admet-2626	418	11	414	414	NUM
admet-2626	418	12	.	.	PUNCT
admet-2626	419	1	https://doi.org/10.1016/j.molliq.2018.07.065	https://doi.org/10.1016/j.molliq.2018.07.065	PROPN
admet-2626	419	2	https://doi.org/10.1007/s10953-022-01141-7	https://doi.org/10.1007/s10953-022-01141-7	NUM
admet-2626	419	3	https://doi.org/10.1007/s10953-022-01199-3	https://doi.org/10.1007/s10953-022-01199-3	NUM
admet-2626	419	4	https://doi.org/10.5599/admet.3.2.193	https://doi.org/10.5599/admet.3.2.193	VERB
admet-2626	419	5	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-2626	419	6	https://doi.org/%2010.5599/admet.704	https://doi.org/%2010.5599/admet.704	VERB
admet-2626	419	7	https://doi.org/10.1016/j.ejps.2021.106043	https://doi.org/10.1016/j.ejps.2021.106043	NOUN
admet-2626	419	8	https://doi.org/10.1021/ac50036a045	https://doi.org/10.1021/ac50036a045	PROPN
admet-2626	419	9	https://doi.org/10.1021/js9901007	https://doi.org/10.1021/js9901007	VERB
admet-2626	419	10	https://doi.org/10.1023/b:pham.0000016237.06815.7a	https://doi.org/10.1023/b:pham.0000016237.06815.7a	PRON
admet-2626	419	11	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	NOUN
admet-2626	419	12	https://doi.org/10.1021/ja01185a065	https://doi.org/10.1021/ja01185a065	PROPN
admet-2626	419	13	https://doi.org/10.1002/jps.10107	https://doi.org/10.1002/jps.10107	PROPN
admet-2626	419	14	https://doi.org/10.5599/admet.1822	https://doi.org/10.5599/admet.1822	NOUN
admet-2626	419	15	https://doi.org/10.1016/j.jct.2005.07.007	https://doi.org/10.1016/j.jct.2005.07.007	NOUN
admet-2626	419	16	https://doi.org/10.1016/j.molliq.2018.07.065	https://doi.org/10.1016/j.molliq.2018.07.065	PROPN
admet-2626	419	17	admet	admet	PROPN
admet-2626	419	18	&	&	CCONJ
admet-2626	419	19	dmpk	dmpk	PROPN
admet-2626	419	20	13(1	13(1	NUM
admet-2626	419	21	)	)	PUNCT
admet-2626	419	22	(	(	PUNCT
admet-2626	419	23	2025	2025	NUM
admet-2626	419	24	)	)	PUNCT
admet-2626	419	25	2626	2626	NUM
admet-2626	419	26	transforming	transform	VERB
admet-2626	419	27	drug	drug	NOUN
admet-2626	419	28	solubility	solubility	NOUN
admet-2626	419	29	measurement	measurement	NOUN
admet-2626	419	30	doi	doi	PROPN
admet-2626	419	31	:	:	PUNCT
admet-2626	419	32	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	419	33	15	15	NUM
admet-2626	420	1	[	[	SYM
admet-2626	420	2	18	18	NUM
admet-2626	420	3	]	]	X
admet-2626	420	4	d.	d.	PROPN
admet-2626	420	5	manhas	manhas	PROPN
admet-2626	420	6	,	,	PUNCT
admet-2626	420	7	s.	s.	PROPN
admet-2626	420	8	dhiman	dhiman	PROPN
admet-2626	420	9	,	,	PUNCT
admet-2626	420	10	h.	h.	PROPN
admet-2626	420	11	kour	kour	PROPN
admet-2626	420	12	,	,	PUNCT
admet-2626	420	13	d.	d.	PROPN
admet-2626	420	14	kour	kour	PROPN
admet-2626	420	15	,	,	PUNCT
admet-2626	420	16	k.	k.	PROPN
admet-2626	420	17	sharma	sharma	PROPN
admet-2626	420	18	,	,	PUNCT
admet-2626	420	19	p.	p.	PROPN
admet-2626	420	20	wazir	wazir	PROPN
admet-2626	420	21	,	,	PUNCT
admet-2626	420	22	b.	b.	PROPN
admet-2626	420	23	vij	vij	PROPN
admet-2626	420	24	,	,	PUNCT
admet-2626	420	25	a.	a.	PROPN
admet-2626	420	26	kumar	kumar	PROPN
admet-2626	420	27	,	,	PUNCT
admet-2626	420	28	s.d	s.d	PROPN
admet-2626	420	29	.	.	PROPN
admet-2626	420	30	sawant	sawant	PROPN
admet-2626	420	31	,	,	PUNCT
admet-2626	420	32	z.	z.	PROPN
admet-2626	420	33	ahmed	ahmed	PROPN
admet-2626	420	34	,	,	PUNCT
admet-2626	420	35	u.	u.	PROPN
admet-2626	420	36	nandi	nandi	PROPN
admet-2626	420	37	.	.	PUNCT
admet-2626	421	1	adme	adme	PROPN
admet-2626	421	2	/	/	SYM
admet-2626	421	3	pk	pk	NOUN
admet-2626	421	4	insights	insight	NOUN
admet-2626	421	5	of	of	ADP
admet-2626	421	6	crocetin	crocetin	NOUN
admet-2626	421	7	:	:	PUNCT
admet-2626	421	8	a	a	DET
admet-2626	421	9	molecule	molecule	NOUN
admet-2626	421	10	having	have	VERB
admet-2626	421	11	an	an	DET
admet-2626	421	12	unusual	unusual	ADJ
admet-2626	421	13	chemical	chemical	NOUN
admet-2626	421	14	structure	structure	NOUN
admet-2626	421	15	with	with	ADP
admet-2626	421	16	druglike	druglike	NOUN
admet-2626	421	17	features	feature	NOUN
admet-2626	421	18	.	.	PUNCT
admet-2626	422	1	acs	acs	PROPN
admet-2626	422	2	omega	omega	NOUN
admet-2626	422	3	9(19	9(19	NUM
admet-2626	422	4	)	)	PUNCT
admet-2626	422	5	(	(	PUNCT
admet-2626	422	6	2024	2024	NUM
admet-2626	422	7	)	)	PUNCT
admet-2626	422	8	21494	21494	NUM
admet-2626	422	9	-	-	SYM
admet-2626	422	10	21509	21509	NUM
admet-2626	422	11	.	.	PUNCT
admet-2626	423	1	https://doi.org/10.1021/acsomega.4c02116	https://doi.org/10.1021/acsomega.4c02116	PRON
admet-2626	423	2	[	[	X
admet-2626	423	3	19	19	NUM
admet-2626	423	4	]	]	X
admet-2626	423	5	f.	f.	PROPN
admet-2626	423	6	shakeel	shakeel	PROPN
admet-2626	423	7	,	,	PUNCT
admet-2626	423	8	n.	n.	PROPN
admet-2626	423	9	haq	haq	PROPN
admet-2626	423	10	,	,	PUNCT
admet-2626	423	11	s.	s.	PROPN
admet-2626	423	12	alshehri	alshehri	PROPN
admet-2626	423	13	,	,	PUNCT
admet-2626	423	14	m.	m.	NOUN
admet-2626	423	15	alenazi	alenazi	PROPN
admet-2626	423	16	,	,	PUNCT
admet-2626	423	17	a.	a.	NOUN
admet-2626	423	18	alwhaibi	alwhaibi	NOUN
admet-2626	423	19	,	,	PUNCT
admet-2626	423	20	i.a	i.a	PROPN
admet-2626	423	21	.	.	PROPN
admet-2626	423	22	alsarra	alsarra	PROPN
admet-2626	423	23	.	.	PUNCT
admet-2626	424	1	solubility	solubility	NOUN
admet-2626	424	2	and	and	CCONJ
admet-2626	424	3	thermodynamic	thermodynamic	ADJ
admet-2626	424	4	analysis	analysis	NOUN
admet-2626	424	5	of	of	ADP
admet-2626	424	6	isotretinoin	isotretinoin	PROPN
admet-2626	424	7	in	in	ADP
admet-2626	424	8	different	different	ADJ
admet-2626	424	9	(	(	PUNCT
admet-2626	424	10	dmso	dmso	NOUN
admet-2626	424	11	+	+	NOUN
admet-2626	424	12	water	water	NOUN
admet-2626	424	13	)	)	PUNCT
admet-2626	424	14	mixtures	mixture	NOUN
admet-2626	424	15	.	.	PUNCT
admet-2626	425	1	molecules	molecule	NOUN
admet-2626	425	2	28	28	NUM
admet-2626	425	3	(	(	PUNCT
admet-2626	425	4	2023	2023	NUM
admet-2626	425	5	)	)	PUNCT
admet-2626	425	6	7110	7110	NUM
admet-2626	425	7	.	.	PUNCT
admet-2626	426	1	https://doi.org/10.3390/molecules28207110	https://doi.org/10.3390/molecules28207110	PROPN
admet-2626	426	2	[	[	X
admet-2626	426	3	20	20	NUM
admet-2626	426	4	]	]	X
admet-2626	426	5	m.m	m.m	PROPN
admet-2626	426	6	.	.	PROPN
admet-2626	426	7	haskins	haskins	PROPN
admet-2626	426	8	,	,	PUNCT
admet-2626	426	9	o.n	o.n	PROPN
admet-2626	426	10	.	.	PROPN
admet-2626	426	11	kavanagh	kavanagh	PROPN
admet-2626	426	12	,	,	PUNCT
admet-2626	426	13	r.	r.	PROPN
admet-2626	426	14	sanii	sanii	PROPN
admet-2626	426	15	,	,	PUNCT
admet-2626	426	16	s.	s.	PROPN
admet-2626	426	17	khorasani	khorasani	PROPN
admet-2626	426	18	,	,	PUNCT
admet-2626	426	19	j.m	j.m	PROPN
admet-2626	426	20	.	.	PROPN
admet-2626	426	21	chen	chen	PROPN
admet-2626	426	22	,	,	PUNCT
admet-2626	426	23	z.y	z.y	PROPN
admet-2626	426	24	.	.	PROPN
admet-2626	426	25	zhang	zhang	PROPN
admet-2626	426	26	,	,	PUNCT
admet-2626	426	27	x.l	x.l	PROPN
admet-2626	426	28	.	.	PROPN
admet-2626	426	29	dai	dai	PROPN
admet-2626	426	30	,	,	PUNCT
admet-2626	426	31	b.y	b.y	PROPN
admet-2626	426	32	.	.	PROPN
admet-2626	426	33	ren	ren	PROPN
admet-2626	426	34	,	,	PUNCT
admet-2626	426	35	t.b	t.b	PROPN
admet-2626	426	36	.	.	PROPN
admet-2626	426	37	lu	lu	PROPN
admet-2626	426	38	,	,	PUNCT
admet-2626	426	39	m.j	m.j	PROPN
admet-2626	426	40	.	.	PROPN
admet-2626	426	41	zaworotko	zaworotko	PROPN
admet-2626	426	42	.	.	PUNCT
admet-2626	427	1	tuning	tune	VERB
admet-2626	427	2	the	the	DET
admet-2626	427	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2626	427	4	performance	performance	NOUN
admet-2626	427	5	of	of	ADP
admet-2626	427	6	quercetin	quercetin	NOUN
admet-2626	427	7	by	by	ADP
admet-2626	427	8	cocrystallization	cocrystallization	NOUN
admet-2626	427	9	.	.	PUNCT
admet-2626	428	1	crystal	crystal	NOUN
admet-2626	428	2	growth	growth	PROPN
admet-2626	428	3	&	&	CCONJ
admet-2626	428	4	design	design	PROPN
admet-2626	428	5	23	23	NUM
admet-2626	428	6	(	(	PUNCT
admet-2626	428	7	2023	2023	NUM
admet-2626	428	8	)	)	PUNCT
admet-2626	428	9	6059	6059	NUM
admet-2626	428	10	-	-	SYM
admet-2626	428	11	6066	6066	NUM
admet-2626	428	12	.	.	PUNCT
admet-2626	429	1	https://doi.org/10.1021/acs.cgd.3c00590	https://doi.org/10.1021/acs.cgd.3c00590	PROPN
admet-2626	429	2	[	[	X
admet-2626	429	3	21	21	NUM
admet-2626	429	4	]	]	PUNCT
admet-2626	429	5	v.	v.	CCONJ
admet-2626	429	6	parvathaneni	parvathaneni	PROPN
admet-2626	429	7	,	,	PUNCT
admet-2626	429	8	r.s	r.s	PROPN
admet-2626	429	9	.	.	PROPN
admet-2626	429	10	elbatanony	elbatanony	NOUN
admet-2626	429	11	,	,	PUNCT
admet-2626	429	12	m.	m.	NOUN
admet-2626	429	13	goyal	goyal	PROPN
admet-2626	429	14	,	,	PUNCT
admet-2626	429	15	t.	t.	NOUN
admet-2626	429	16	chavan	chavan	PROPN
admet-2626	429	17	,	,	PUNCT
admet-2626	429	18	n.	n.	PROPN
admet-2626	429	19	vega	vega	PROPN
admet-2626	429	20	,	,	PUNCT
admet-2626	429	21	s.	s.	PROPN
admet-2626	429	22	kolluru	kolluru	PROPN
admet-2626	429	23	,	,	PUNCT
admet-2626	429	24	a.	a.	NOUN
admet-2626	429	25	muth	muth	PROPN
admet-2626	429	26	,	,	PUNCT
admet-2626	429	27	v.	v.	PROPN
admet-2626	429	28	gupta	gupta	PROPN
admet-2626	429	29	,	,	PUNCT
admet-2626	429	30	n.k	n.k	PROPN
admet-2626	429	31	.	.	PROPN
admet-2626	429	32	kunda	kunda	NOUN
admet-2626	429	33	.	.	PUNCT
admet-2626	430	1	repurposing	repurpose	VERB
admet-2626	430	2	bedaquiline	bedaquiline	NOUN
admet-2626	430	3	for	for	ADP
admet-2626	430	4	effective	effective	ADJ
admet-2626	430	5	non	non	ADJ
admet-2626	430	6	-	-	ADJ
admet-2626	430	7	small	small	ADJ
admet-2626	430	8	cell	cell	NOUN
admet-2626	430	9	lung	lung	NOUN
admet-2626	430	10	cancer	cancer	NOUN
admet-2626	430	11	(	(	PUNCT
admet-2626	430	12	nsclc	nsclc	NOUN
admet-2626	430	13	)	)	PUNCT
admet-2626	430	14	therapy	therapy	NOUN
admet-2626	430	15	as	as	ADP
admet-2626	430	16	inhalable	inhalable	ADJ
admet-2626	430	17	cyclodextrin	cyclodextrin	NOUN
admet-2626	430	18	-	-	PUNCT
admet-2626	430	19	based	base	VERB
admet-2626	430	20	molecular	molecular	ADJ
admet-2626	430	21	inclusion	inclusion	NOUN
admet-2626	430	22	complexes	complex	NOUN
admet-2626	430	23	.	.	PUNCT
admet-2626	431	1	international	international	ADJ
admet-2626	431	2	journal	journal	NOUN
admet-2626	431	3	of	of	ADP
admet-2626	431	4	molecular	molecular	ADJ
admet-2626	431	5	sciences	science	NOUN
admet-2626	431	6	22	22	NUM
admet-2626	431	7	(	(	PUNCT
admet-2626	431	8	2021	2021	NUM
admet-2626	431	9	)	)	PUNCT
admet-2626	431	10	4783	4783	NUM
admet-2626	431	11	.	.	PUNCT
admet-2626	432	1	https://doi.org/10.3390/ijms22094783	https://doi.org/10.3390/ijms22094783	NOUN
admet-2626	432	2	[	[	X
admet-2626	432	3	22	22	NUM
admet-2626	432	4	]	]	X
admet-2626	432	5	v.b	v.b	PROPN
admet-2626	432	6	.	.	PROPN
admet-2626	432	7	ghawate	ghawate	PROPN
admet-2626	432	8	,	,	PUNCT
admet-2626	432	9	a.r	a.r	PROPN
admet-2626	432	10	.	.	PROPN
admet-2626	432	11	pawar	pawar	PROPN
admet-2626	432	12	,	,	PUNCT
admet-2626	432	13	g.p	g.p	PROPN
admet-2626	432	14	.	.	PROPN
admet-2626	432	15	sangale	sangale	PROPN
admet-2626	432	16	,	,	PUNCT
admet-2626	432	17	a.r	a.r	PROPN
admet-2626	432	18	.	.	PROPN
admet-2626	432	19	yadav	yadav	PROPN
admet-2626	432	20	.	.	PUNCT
admet-2626	432	21	enhancement	enhancement	NOUN
admet-2626	432	22	of	of	ADP
admet-2626	432	23	solubility	solubility	NOUN
admet-2626	432	24	and	and	CCONJ
admet-2626	432	25	dissolution	dissolution	NOUN
admet-2626	432	26	rate	rate	NOUN
admet-2626	432	27	of	of	ADP
admet-2626	432	28	lumefantrine	lumefantrine	NOUN
admet-2626	432	29	by	by	ADP
admet-2626	432	30	pharmaceutical	pharmaceutical	ADJ
admet-2626	432	31	cocrystals	cocrystal	NOUN
admet-2626	432	32	.	.	PUNCT
admet-2626	433	1	asian	asian	ADJ
admet-2626	433	2	journal	journal	PROPN
admet-2626	433	3	of	of	ADP
admet-2626	433	4	pharmaceutics	pharmaceutic	NOUN
admet-2626	433	5	,	,	PUNCT
admet-2626	433	6	17	17	NUM
admet-2626	433	7	(	(	PUNCT
admet-2626	433	8	2023	2023	NUM
admet-2626	433	9	)	)	PUNCT
admet-2626	433	10	215	215	NUM
admet-2626	433	11	-	-	SYM
admet-2626	433	12	220	220	NUM
admet-2626	433	13	.	.	PUNCT
admet-2626	434	1	https://doi.org/10.22377/ajp.v17i2.4848	https://doi.org/10.22377/ajp.v17i2.4848	PROPN
admet-2626	435	1	[	[	X
admet-2626	435	2	23	23	NUM
admet-2626	435	3	]	]	X
admet-2626	435	4	d.	d.	PROPN
admet-2626	435	5	sorgi	sorgi	PROPN
admet-2626	435	6	,	,	PUNCT
admet-2626	435	7	a.	a.	NOUN
admet-2626	435	8	sartori	sartori	PROPN
admet-2626	435	9	,	,	PUNCT
admet-2626	435	10	s.	s.	PROPN
admet-2626	435	11	germani	germani	PROPN
admet-2626	435	12	,	,	PUNCT
admet-2626	435	13	r.n	r.n	PROPN
admet-2626	435	14	.	.	PROPN
admet-2626	435	15	gentile	gentile	NOUN
admet-2626	435	16	,	,	PUNCT
admet-2626	435	17	a.	a.	NOUN
admet-2626	435	18	bianchera	bianchera	PROPN
admet-2626	435	19	,	,	PUNCT
admet-2626	435	20	r.	r.	PROPN
admet-2626	435	21	bettini	bettini	PROPN
admet-2626	435	22	.	.	PUNCT
admet-2626	436	1	imiquimod	imiquimod	PROPN
admet-2626	436	2	solubility	solubility	NOUN
admet-2626	436	3	in	in	ADP
admet-2626	436	4	different	different	ADJ
admet-2626	436	5	solvents	solvent	NOUN
admet-2626	436	6	:	:	PUNCT
admet-2626	436	7	an	an	DET
admet-2626	436	8	interpretative	interpretative	ADJ
admet-2626	436	9	approach	approach	NOUN
admet-2626	436	10	.	.	PUNCT
admet-2626	437	1	pharmaceutics	pharmaceutic	NOUN
admet-2626	437	2	16	16	NUM
admet-2626	437	3	(	(	PUNCT
admet-2626	437	4	2024	2024	NUM
admet-2626	437	5	)	)	PUNCT
admet-2626	437	6	282	282	NUM
admet-2626	437	7	.	.	PUNCT
admet-2626	438	1	https://doi.org/10.3390/pharmaceutics16020282	https://doi.org/10.3390/pharmaceutics16020282	PROPN
admet-2626	438	2	[	[	X
admet-2626	438	3	24	24	NUM
admet-2626	438	4	]	]	X
admet-2626	438	5	b.m.h	b.m.h	NOUN
admet-2626	438	6	.	.	PUNCT
admet-2626	439	1	al	al	PROPN
admet-2626	439	2	-	-	PUNCT
admet-2626	439	3	hadiya	hadiya	PROPN
admet-2626	439	4	,	,	PUNCT
admet-2626	439	5	a.h.h	a.h.h	PROPN
admet-2626	439	6	.	.	PUNCT
admet-2626	439	7	bakheit	bakheit	PROPN
admet-2626	439	8	,	,	PUNCT
admet-2626	439	9	a.a	a.a	PROPN
admet-2626	439	10	.	.	PROPN
admet-2626	439	11	abd	abd	PROPN
admet-2626	439	12	-	-	PUNCT
admet-2626	439	13	elgalil	elgalil	PROPN
admet-2626	439	14	.	.	PUNCT
admet-2626	440	1	chapter	chapter	NOUN
admet-2626	440	2	six	six	NUM
admet-2626	440	3	imatinib	imatinib	NOUN
admet-2626	440	4	mesylate	mesylate	NOUN
admet-2626	440	5	.	.	PUNCT
admet-2626	441	1	profiles	profile	NOUN
admet-2626	441	2	of	of	ADP
admet-2626	441	3	drug	drug	NOUN
admet-2626	441	4	substances	substance	NOUN
admet-2626	441	5	,	,	PUNCT
admet-2626	441	6	excipients	excipient	NOUN
admet-2626	441	7	and	and	CCONJ
admet-2626	441	8	related	relate	VERB
admet-2626	441	9	methodology	methodology	NOUN
admet-2626	441	10	39	39	NUM
admet-2626	441	11	(	(	PUNCT
admet-2626	441	12	2014	2014	NUM
admet-2626	441	13	)	)	PUNCT
admet-2626	441	14	265	265	NUM
admet-2626	441	15	-	-	SYM
admet-2626	441	16	297	297	NUM
admet-2626	441	17	.	.	PUNCT
admet-2626	442	1	https://doi.org/10.1016/b978-012-800173-8.00006-4	https://doi.org/10.1016/b978-012-800173-8.00006-4	PROPN
admet-2626	442	2	[	[	X
admet-2626	442	3	25	25	NUM
admet-2626	442	4	]	]	PUNCT
admet-2626	442	5	takeda	takeda	PROPN
admet-2626	442	6	canada	canada	PROPN
admet-2626	442	7	inc	inc	PROPN
admet-2626	442	8	.	.	PROPN
admet-2626	442	9	alunbrig	alunbrig	PROPN
admet-2626	442	10	™	™	PROPN
admet-2626	442	11	(	(	PUNCT
admet-2626	442	12	brigatinib	brigatinib	NOUN
admet-2626	442	13	)	)	PUNCT
admet-2626	442	14	product	product	NOUN
admet-2626	442	15	monograph	monograph	NOUN
admet-2626	442	16	.	.	PUNCT
admet-2626	443	1	28	28	NUM
admet-2626	443	2	nov	nov	PROPN
admet-2626	443	3	2019	2019	NUM
admet-2626	443	4	.	.	PUNCT
admet-2626	444	1	https://www.takeda.com/siteassets/en-ca/home/what-we-do/our-medicines/productmonographs/alunbrig/alunbrig-pm-en.pdf	https://www.takeda.com/siteassets/en-ca/home/what-we-do/our-medicines/productmonographs/alunbrig/alunbrig-pm-en.pdf	NOUN
admet-2626	445	1	[	[	X
admet-2626	445	2	26	26	NUM
admet-2626	445	3	]	]	X
admet-2626	445	4	s.z	s.z	PROPN
admet-2626	445	5	.	.	PROPN
admet-2626	445	6	asghar	asghar	PROPN
admet-2626	445	7	,	,	PUNCT
admet-2626	445	8	r.	r.	PROPN
admet-2626	445	9	kaviani	kaviani	PROPN
admet-2626	445	10	,	,	PUNCT
admet-2626	445	11	a.	a.	PROPN
admet-2626	445	12	shayanfar	shayanfar	PROPN
admet-2626	445	13	.	.	PUNCT
admet-2626	446	1	solubility	solubility	NOUN
admet-2626	446	2	of	of	ADP
admet-2626	446	3	some	some	DET
admet-2626	446	4	drugs	drug	NOUN
admet-2626	446	5	in	in	ADP
admet-2626	446	6	aqueous	aqueous	ADJ
admet-2626	446	7	solutions	solution	NOUN
admet-2626	446	8	of	of	ADP
admet-2626	446	9	choline	choline	NOUN
admet-2626	446	10	chloride	chloride	NOUN
admet-2626	446	11	-	-	PUNCT
admet-2626	446	12	based	base	VERB
admet-2626	446	13	deep	deep	ADJ
admet-2626	446	14	eutectic	eutectic	ADJ
admet-2626	446	15	solvent	solvent	NOUN
admet-2626	446	16	systems	system	NOUN
admet-2626	446	17	:	:	PUNCT
admet-2626	446	18	experimental	experimental	ADJ
admet-2626	446	19	data	datum	NOUN
admet-2626	446	20	,	,	PUNCT
admet-2626	446	21	modeling	modeling	NOUN
admet-2626	446	22	,	,	PUNCT
admet-2626	446	23	and	and	CCONJ
admet-2626	446	24	the	the	DET
admet-2626	446	25	impact	impact	NOUN
admet-2626	446	26	of	of	ADP
admet-2626	446	27	solution	solution	NOUN
admet-2626	446	28	ph	ph	VERB
admet-2626	446	29	.	.	PROPN
admet-2626	446	30	iranian	iranian	PROPN
admet-2626	446	31	journal	journal	PROPN
admet-2626	446	32	of	of	ADP
admet-2626	446	33	pharmaceutical	pharmaceutical	PROPN
admet-2626	446	34	research	research	PROPN
admet-2626	446	35	22(1	22(1	NUM
admet-2626	446	36	)	)	PUNCT
admet-2626	446	37	(	(	PUNCT
admet-2626	446	38	2023	2023	NUM
admet-2626	446	39	)	)	PUNCT
admet-2626	446	40	e137011	e137011	NOUN
admet-2626	446	41	.	.	PUNCT
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admet-2626	449	10	.	.	PUNCT
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admet-2626	450	3	(	(	PUNCT
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admet-2626	450	7	-	-	SYM
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admet-2626	450	9	.	.	PUNCT
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admet-2626	460	7	.	.	PUNCT
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admet-2626	467	15	-	-	SYM
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admet-2626	479	1	journal	journal	NOUN
admet-2626	479	2	of	of	ADP
admet-2626	479	3	pharmaceutical	pharmaceutical	PROPN
admet-2626	479	4	sciences	science	NOUN
admet-2626	479	5	82	82	NUM
admet-2626	479	6	(	(	PUNCT
admet-2626	479	7	1992	1992	NUM
admet-2626	479	8	)	)	PUNCT
admet-2626	479	9	183	183	NUM
admet-2626	479	10	-	-	SYM
admet-2626	479	11	190	190	NUM
admet-2626	479	12	.	.	PUNCT
admet-2626	480	1	https://doi.org/10.1002/jps.2600820214	https://doi.org/10.1002/jps.2600820214	PROPN
admet-2626	481	1	[	[	X
admet-2626	481	2	37	37	NUM
admet-2626	481	3	]	]	PUNCT
admet-2626	481	4	a.	a.	NOUN
admet-2626	481	5	avdeef	avdeef	PROPN
admet-2626	481	6	.	.	PUNCT
admet-2626	482	1	ph	ph	VERB
admet-2626	482	2	-	-	ADJ
admet-2626	482	3	metric	metric	ADJ
admet-2626	482	4	solubility	solubility	NOUN
admet-2626	482	5	.	.	PUNCT
admet-2626	483	1	1	1	X
admet-2626	483	2	.	.	X
admet-2626	483	3	solubility	solubility	NOUN
admet-2626	483	4	-	-	PUNCT
admet-2626	483	5	ph	ph	NOUN
admet-2626	483	6	profiles	profile	NOUN
admet-2626	483	7	from	from	ADP
admet-2626	483	8	bjerrum	bjerrum	NOUN
admet-2626	483	9	plots	plot	NOUN
admet-2626	483	10	.	.	PUNCT
admet-2626	484	1	gibbs	gibbs	PROPN
admet-2626	484	2	buffer	buffer	NOUN
admet-2626	484	3	and	and	CCONJ
admet-2626	484	4	pka	pka	VERB
admet-2626	484	5	in	in	ADP
admet-2626	484	6	the	the	DET
admet-2626	484	7	solid	solid	ADJ
admet-2626	484	8	state	state	NOUN
admet-2626	484	9	.	.	PUNCT
admet-2626	485	1	pharmacy	pharmacy	NOUN
admet-2626	485	2	and	and	CCONJ
admet-2626	485	3	pharmacology	pharmacology	NOUN
admet-2626	485	4	communications	communication	NOUN
admet-2626	485	5	4	4	NUM
admet-2626	485	6	(	(	PUNCT
admet-2626	485	7	1998	1998	NUM
admet-2626	485	8	)	)	PUNCT
admet-2626	485	9	165	165	NUM
admet-2626	485	10	-	-	SYM
admet-2626	485	11	178	178	NUM
admet-2626	485	12	.	.	PUNCT
admet-2626	486	1	https://doi.org/10.1111/j.2042-7158.1998.tb00328.x	https://doi.org/10.1111/j.2042-7158.1998.tb00328.x	NOUN
admet-2626	487	1	[	[	X
admet-2626	487	2	38	38	NUM
admet-2626	487	3	]	]	PUNCT
admet-2626	487	4	a.	a.	NOUN
admet-2626	487	5	avdeef	avdeef	PROPN
admet-2626	487	6	.	.	PUNCT
admet-2626	488	1	solubility	solubility	NOUN
admet-2626	488	2	of	of	ADP
admet-2626	488	3	sparingly	sparingly	ADV
admet-2626	488	4	-	-	PUNCT
admet-2626	488	5	soluble	soluble	ADJ
admet-2626	488	6	drugs	drug	NOUN
admet-2626	488	7	.	.	PUNCT
admet-2626	489	1	advanced	advanced	ADJ
admet-2626	489	2	drug	drug	NOUN
admet-2626	489	3	delivery	delivery	NOUN
admet-2626	489	4	reviews	review	VERB
admet-2626	489	5	59	59	NUM
admet-2626	489	6	(	(	PUNCT
admet-2626	489	7	2007	2007	NUM
admet-2626	489	8	)	)	PUNCT
admet-2626	489	9	568	568	NUM
admet-2626	489	10	-	-	SYM
admet-2626	489	11	590	590	NUM
admet-2626	489	12	.	.	PUNCT
admet-2626	490	1	https://doi.org/10.1016/j.addr.2007.05.008	https://doi.org/10.1016/j.addr.2007.05.008	NOUN
admet-2626	491	1	[	[	X
admet-2626	491	2	39	39	NUM
admet-2626	491	3	]	]	PUNCT
admet-2626	491	4	c.a.s	c.a.s	PROPN
admet-2626	491	5	.	.	PROPN
admet-2626	491	6	bergström	bergström	NOUN
admet-2626	491	7	,	,	PUNCT
admet-2626	491	8	a.	a.	NOUN
admet-2626	491	9	avdeef	avdeef	PROPN
admet-2626	491	10	.	.	PUNCT
admet-2626	492	1	perspectives	perspective	NOUN
admet-2626	492	2	in	in	ADP
admet-2626	492	3	solubility	solubility	NOUN
admet-2626	492	4	measurement	measurement	NOUN
admet-2626	492	5	and	and	CCONJ
admet-2626	492	6	interpretation	interpretation	NOUN
admet-2626	492	7	.	.	PUNCT
admet-2626	493	1	admet	admet	PROPN
admet-2626	493	2	&	&	CCONJ
admet-2626	493	3	dmpk	dmpk	PROPN
admet-2626	493	4	7	7	NUM
admet-2626	493	5	(	(	PUNCT
admet-2626	493	6	2019	2019	NUM
admet-2626	493	7	)	)	PUNCT
admet-2626	493	8	88	88	NUM
admet-2626	493	9	-	-	SYM
admet-2626	493	10	105	105	NUM
admet-2626	493	11	.	.	PUNCT
admet-2626	493	12	https://doi.org/10.5599/admet.686	https://doi.org/10.5599/admet.686	X
admet-2626	494	1	[	[	X
admet-2626	494	2	40	40	NUM
admet-2626	494	3	]	]	PUNCT
admet-2626	494	4	g.	g.	PROPN
admet-2626	494	5	völgyi	völgyi	PROPN
admet-2626	494	6	,	,	PUNCT
admet-2626	494	7	a.	a.	NOUN
admet-2626	494	8	marosi	marosi	PROPN
admet-2626	494	9	,	,	PUNCT
admet-2626	494	10	k.a	k.a	PROPN
admet-2626	494	11	.	.	PROPN
admet-2626	494	12	takács	takács	PROPN
admet-2626	494	13	-	-	PUNCT
admet-2626	494	14	novák	novák	PROPN
admet-2626	494	15	,	,	PUNCT
admet-2626	494	16	a.	a.	NOUN
admet-2626	494	17	avdeef	avdeef	PROPN
admet-2626	494	18	.	.	PUNCT
admet-2626	495	1	salt	salt	NOUN
admet-2626	495	2	solubility	solubility	NOUN
admet-2626	495	3	products	product	NOUN
admet-2626	495	4	of	of	ADP
admet-2626	495	5	diprenorphine	diprenorphine	NOUN
admet-2626	495	6	hydrochloride	hydrochloride	NOUN
admet-2626	495	7	,	,	PUNCT
admet-2626	495	8	codeine	codeine	NOUN
admet-2626	495	9	and	and	CCONJ
admet-2626	495	10	lidocaine	lidocaine	NOUN
admet-2626	495	11	hydrochlorides	hydrochloride	NOUN
admet-2626	495	12	and	and	CCONJ
admet-2626	495	13	phosphates	phosphate	NOUN
admet-2626	495	14	novel	novel	ADJ
admet-2626	495	15	method	method	NOUN
admet-2626	495	16	of	of	ADP
admet-2626	495	17	data	datum	NOUN
admet-2626	495	18	analysis	analysis	NOUN
admet-2626	495	19	not	not	PART
admet-2626	495	20	dependent	dependent	ADJ
admet-2626	495	21	on	on	ADP
admet-2626	495	22	explicit	explicit	ADJ
admet-2626	495	23	solubility	solubility	NOUN
admet-2626	495	24	equations	equation	NOUN
admet-2626	495	25	.	.	PUNCT
admet-2626	496	1	admet	admet	PROPN
admet-2626	496	2	&	&	CCONJ
admet-2626	496	3	dmpk	dmpk	PROPN
admet-2626	496	4	1	1	NUM
admet-2626	496	5	(	(	PUNCT
admet-2626	496	6	2013	2013	NUM
admet-2626	496	7	)	)	PUNCT
admet-2626	496	8	48	48	NUM
admet-2626	496	9	-	-	SYM
admet-2626	496	10	62	62	NUM
admet-2626	496	11	.	.	PUNCT
admet-2626	497	1	https://doi.org/10.5599/admet.1.4.24	https://doi.org/10.5599/admet.1.4.24	PROPN
admet-2626	498	1	[	[	X
admet-2626	498	2	41	41	NUM
admet-2626	498	3	]	]	X
admet-2626	498	4	e.	e.	PROPN
admet-2626	498	5	fuguet	fuguet	PROPN
admet-2626	498	6	,	,	PUNCT
admet-2626	498	7	x.	x.	NOUN
admet-2626	498	8	subirats	subirat	NOUN
admet-2626	498	9	,	,	PUNCT
admet-2626	498	10	c.	c.	PROPN
admet-2626	498	11	ràfols	ràfols	PROPN
admet-2626	498	12	,	,	PUNCT
admet-2626	498	13	e.a	e.a	PROPN
admet-2626	498	14	.	.	PROPN
admet-2626	498	15	bosch	bosch	PROPN
admet-2626	498	16	,	,	PUNCT
admet-2626	498	17	a.	a.	PROPN
admet-2626	498	18	avdeef	avdeef	PROPN
admet-2626	498	19	.	.	PUNCT
admet-2626	499	1	ionizable	ionizable	ADJ
admet-2626	499	2	drug	drug	NOUN
admet-2626	499	3	self	self	NOUN
admet-2626	499	4	-	-	PUNCT
admet-2626	499	5	associations	association	NOUN
admet-2626	499	6	and	and	CCONJ
admet-2626	499	7	the	the	DET
admet-2626	499	8	solubility	solubility	NOUN
admet-2626	499	9	dependence	dependence	NOUN
admet-2626	499	10	on	on	ADP
admet-2626	499	11	ph	ph	ADJ
admet-2626	499	12	:	:	PUNCT
admet-2626	499	13	detection	detection	NOUN
admet-2626	499	14	of	of	ADP
admet-2626	499	15	aggregates	aggregate	NOUN
admet-2626	499	16	in	in	ADP
admet-2626	499	17	saturated	saturated	ADJ
admet-2626	499	18	solutions	solution	NOUN
admet-2626	499	19	using	use	VERB
admet-2626	499	20	mass	mass	ADJ
admet-2626	499	21	spectrometry	spectrometry	NOUN
admet-2626	499	22	(	(	PUNCT
admet-2626	499	23	esi	esi	PROPN
admet-2626	499	24	-	-	ADJ
admet-2626	499	25	q	q	ADJ
admet-2626	499	26	-	-	PUNCT
admet-2626	499	27	tof	tof	PROPN
admet-2626	499	28	-	-	PUNCT
admet-2626	499	29	ms	ms	PROPN
admet-2626	499	30	/	/	SYM
admet-2626	499	31	ms	ms	NOUN
admet-2626	499	32	)	)	PUNCT
admet-2626	499	33	.	.	PUNCT
admet-2626	500	1	molecular	molecular	ADJ
admet-2626	500	2	pharmaceutics	pharmaceutic	NOUN
admet-2626	500	3	18	18	NUM
admet-2626	500	4	(	(	PUNCT
admet-2626	500	5	2021	2021	NUM
admet-2626	500	6	)	)	PUNCT
admet-2626	500	7	2311	2311	NUM
admet-2626	500	8	-	-	SYM
admet-2626	500	9	2321	2321	NUM
admet-2626	500	10	.	.	PUNCT
admet-2626	501	1	https://doi.org/10.1021/acs.molpharmaceut.1c00131	https://doi.org/10.1021/acs.molpharmaceut.1c00131	X
admet-2626	502	1	[	[	X
admet-2626	502	2	42	42	NUM
admet-2626	502	3	]	]	PUNCT
admet-2626	502	4	a.	a.	NOUN
admet-2626	502	5	avdeef	avdeef	PROPN
admet-2626	502	6	.	.	PUNCT
admet-2626	503	1	anomalous	anomalous	ADJ
admet-2626	503	2	solubility	solubility	NOUN
admet-2626	503	3	behavior	behavior	NOUN
admet-2626	503	4	of	of	ADP
admet-2626	503	5	several	several	ADJ
admet-2626	503	6	acidic	acidic	ADJ
admet-2626	503	7	drugs	drug	NOUN
admet-2626	503	8	.	.	PUNCT
admet-2626	504	1	admet	admet	PROPN
admet-2626	504	2	&	&	CCONJ
admet-2626	504	3	dmpk	dmpk	PROPN
admet-2626	504	4	2	2	NUM
admet-2626	504	5	(	(	PUNCT
admet-2626	504	6	2014	2014	NUM
admet-2626	504	7	)	)	PUNCT
admet-2626	504	8	33	33	NUM
admet-2626	504	9	-	-	SYM
admet-2626	504	10	42	42	NUM
admet-2626	504	11	.	.	PUNCT
admet-2626	505	1	https://doi.org/10.5599/admet.2.1.30	https://doi.org/10.5599/admet.2.1.30	PROPN
admet-2626	506	1	[	[	X
admet-2626	506	2	43	43	NUM
admet-2626	506	3	]	]	PUNCT
admet-2626	506	4	a.	a.	NOUN
admet-2626	506	5	avdeef	avdeef	PROPN
admet-2626	506	6	.	.	PUNCT
admet-2626	507	1	phosphate	phosphate	ADJ
admet-2626	507	2	precipitates	precipitate	NOUN
admet-2626	507	3	and	and	CCONJ
admet-2626	507	4	water	water	NOUN
admet-2626	507	5	-	-	PUNCT
admet-2626	507	6	soluble	soluble	ADJ
admet-2626	507	7	aggregates	aggregate	NOUN
admet-2626	507	8	in	in	ADP
admet-2626	507	9	re	re	VERB
admet-2626	507	10	-	-	VERB
admet-2626	507	11	examined	examine	VERB
admet-2626	507	12	solubility	solubility	NOUN
admet-2626	507	13	-	-	PUNCT
admet-2626	507	14	ph	ph	ADJ
admet-2626	507	15	data	datum	NOUN
admet-2626	507	16	of	of	ADP
admet-2626	507	17	twenty	twenty	NUM
admet-2626	507	18	-	-	PUNCT
admet-2626	507	19	five	five	NUM
admet-2626	507	20	basic	basic	ADJ
admet-2626	507	21	drugs	drug	NOUN
admet-2626	507	22	.	.	PUNCT
admet-2626	508	1	admet	admet	PROPN
admet-2626	508	2	&	&	CCONJ
admet-2626	508	3	dmpk	dmpk	PROPN
admet-2626	508	4	2	2	NUM
admet-2626	508	5	(	(	PUNCT
admet-2626	508	6	2014	2014	NUM
admet-2626	508	7	)	)	PUNCT
admet-2626	508	8	43	43	NUM
admet-2626	508	9	-	-	SYM
admet-2626	508	10	55	55	NUM
admet-2626	508	11	.	.	PUNCT
admet-2626	509	1	https://doi.org/10.5599/admet.2.1.31	https://doi.org/10.5599/admet.2.1.31	PROPN
admet-2626	509	2	[	[	X
admet-2626	509	3	44	44	NUM
admet-2626	509	4	]	]	PUNCT
admet-2626	509	5	g.	g.	NOUN
admet-2626	509	6	butcher	butcher	NOUN
admet-2626	509	7	,	,	PUNCT
admet-2626	509	8	j.a	j.a	PROPN
admet-2626	509	9	.	.	PROPN
admet-2626	509	10	comer	comer	PROPN
admet-2626	509	11	,	,	PUNCT
admet-2626	509	12	a.	a.	NOUN
admet-2626	509	13	avdeef	avdeef	PROPN
admet-2626	509	14	.	.	PUNCT
admet-2626	510	1	pka	pka	ADJ
admet-2626	510	2	-	-	ADJ
admet-2626	510	3	critical	critical	ADJ
admet-2626	510	4	interpretations	interpretation	NOUN
admet-2626	510	5	of	of	ADP
admet-2626	510	6	solubility	solubility	NOUN
admet-2626	510	7	-	-	PUNCT
admet-2626	510	8	ph	ph	ADJ
admet-2626	510	9	profiles	profile	NOUN
admet-2626	510	10	:	:	PUNCT
admet-2626	510	11	pg-300995	pg-300995	NOUN
admet-2626	510	12	and	and	CCONJ
admet-2626	510	13	nsc-639829	nsc-639829	NOUN
admet-2626	510	14	case	case	NOUN
admet-2626	510	15	studies	study	NOUN
admet-2626	510	16	.	.	PUNCT
admet-2626	511	1	admet	admet	PROPN
admet-2626	511	2	&	&	CCONJ
admet-2626	511	3	dmpk	dmpk	PROPN
admet-2626	511	4	3	3	NUM
admet-2626	511	5	(	(	PUNCT
admet-2626	511	6	2015	2015	NUM
admet-2626	511	7	)	)	PUNCT
admet-2626	511	8	131	131	NUM
admet-2626	511	9	-	-	SYM
admet-2626	511	10	140	140	NUM
admet-2626	511	11	.	.	PUNCT
admet-2626	512	1	https://doi.org/10.5599/admet.3.2.182	https://doi.org/10.5599/admet.3.2.182	NOUN
admet-2626	512	2	[	[	X
admet-2626	512	3	45	45	NUM
admet-2626	512	4	]	]	PUNCT
admet-2626	512	5	c.	c.	PROPN
admet-2626	512	6	miranda	miranda	PROPN
admet-2626	512	7	,	,	PUNCT
admet-2626	512	8	a.	a.	PROPN
admet-2626	512	9	ruiz	ruiz	NOUN
admet-2626	512	10	-	-	PUNCT
admet-2626	512	11	picazo	picazo	NOUN
admet-2626	512	12	,	,	PUNCT
admet-2626	512	13	p.	p.	NOUN
admet-2626	512	14	pomares	pomare	NOUN
admet-2626	512	15	,	,	PUNCT
admet-2626	512	16	i.	i.	PROPN
admet-2626	512	17	gonzalez	gonzalez	PROPN
admet-2626	512	18	-	-	PUNCT
admet-2626	512	19	alvarez	alvarez	PROPN
admet-2626	512	20	,	,	PUNCT
admet-2626	512	21	m.	m.	NOUN
admet-2626	512	22	bermejo	bermejo	PROPN
admet-2626	512	23	,	,	PUNCT
admet-2626	512	24	m.	m.	NOUN
admet-2626	512	25	gonzalez	gonzalez	PROPN
admet-2626	512	26	-	-	PUNCT
admet-2626	512	27	alvarez	alvarez	PROPN
admet-2626	512	28	,	,	PUNCT
admet-2626	512	29	a.	a.	NOUN
admet-2626	512	30	avdeef	avdeef	PROPN
admet-2626	512	31	,	,	PUNCT
admet-2626	512	32	m.á	m.á	PROPN
admet-2626	512	33	.	.	PROPN
admet-2626	512	34	cabrera	cabrera	NOUN
admet-2626	512	35	-	-	PUNCT
admet-2626	512	36	pérez	pérez	NOUN
admet-2626	512	37	.	.	PUNCT
admet-2626	513	1	integration	integration	NOUN
admet-2626	513	2	of	of	ADP
admet-2626	513	3	in	in	ADP
admet-2626	513	4	silico	silico	NOUN
admet-2626	513	5	,	,	PUNCT
admet-2626	513	6	in	in	ADP
admet-2626	513	7	vitro	vitro	X
admet-2626	513	8	and	and	CCONJ
admet-2626	513	9	in	in	ADP
admet-2626	513	10	situ	situ	ADJ
admet-2626	513	11	tools	tool	NOUN
admet-2626	513	12	for	for	ADP
admet-2626	513	13	the	the	DET
admet-2626	513	14	preformulation	preformulation	NOUN
admet-2626	513	15	and	and	CCONJ
admet-2626	513	16	characterization	characterization	NOUN
admet-2626	513	17	of	of	ADP
admet-2626	513	18	a	a	DET
admet-2626	513	19	novel	novel	ADJ
admet-2626	513	20	cardio	cardio	NOUN
admet-2626	513	21	-	-	PUNCT
admet-2626	513	22	neuroprotective	neuroprotective	ADJ
admet-2626	513	23	compound	compound	NOUN
admet-2626	513	24	during	during	ADP
admet-2626	513	25	the	the	DET
admet-2626	513	26	early	early	ADJ
admet-2626	513	27	stages	stage	NOUN
admet-2626	513	28	of	of	ADP
admet-2626	513	29	drug	drug	NOUN
admet-2626	513	30	development	development	NOUN
admet-2626	513	31	.	.	PUNCT
admet-2626	514	1	pharmaceutics	pharmaceutic	NOUN
admet-2626	514	2	14	14	NUM
admet-2626	514	3	(	(	PUNCT
admet-2626	514	4	2022	2022	NUM
admet-2626	514	5	)	)	PUNCT
admet-2626	514	6	182	182	NUM
admet-2626	514	7	.	.	PUNCT
admet-2626	515	1	https://doi.org/10.3390/pharmaceutics14010182	https://doi.org/10.3390/pharmaceutics14010182	PROPN
admet-2626	516	1	[	[	X
admet-2626	516	2	46	46	NUM
admet-2626	516	3	]	]	PUNCT
admet-2626	516	4	a.	a.	NOUN
admet-2626	516	5	avdeef	avdeef	PROPN
admet-2626	516	6	.	.	PUNCT
admet-2626	517	1	cocrystal	cocrystal	PROPN
admet-2626	517	2	solubility	solubility	NOUN
admet-2626	517	3	product	product	NOUN
admet-2626	517	4	analysis	analysis	NOUN
admet-2626	517	5	dual	dual	ADJ
admet-2626	517	6	concentration	concentration	NOUN
admet-2626	517	7	-	-	PUNCT
admet-2626	517	8	ph	ph	ADJ
admet-2626	517	9	mass	mass	NOUN
admet-2626	517	10	action	action	NOUN
admet-2626	517	11	model	model	NOUN
admet-2626	517	12	not	not	PART
admet-2626	517	13	dependent	dependent	ADJ
admet-2626	517	14	on	on	ADP
admet-2626	517	15	explicit	explicit	ADJ
admet-2626	517	16	solubility	solubility	NOUN
admet-2626	517	17	equations	equation	NOUN
admet-2626	517	18	.	.	PUNCT
admet-2626	518	1	european	european	PROPN
admet-2626	518	2	journal	journal	PROPN
admet-2626	518	3	of	of	ADP
admet-2626	518	4	pharmaceutical	pharmaceutical	PROPN
admet-2626	518	5	sciences	science	NOUN
admet-2626	518	6	110	110	NUM
admet-2626	518	7	(	(	PUNCT
admet-2626	518	8	2017	2017	NUM
admet-2626	518	9	)	)	PUNCT
admet-2626	518	10	2	2	NUM
admet-2626	518	11	-	-	SYM
admet-2626	518	12	18	18	NUM
admet-2626	518	13	.	.	PUNCT
admet-2626	519	1	https://doi.org/10.1016/j.ejps.2017.03.049	https://doi.org/10.1016/j.ejps.2017.03.049	NOUN
admet-2626	519	2	[	[	X
admet-2626	519	3	47	47	NUM
admet-2626	519	4	]	]	PUNCT
admet-2626	519	5	a.	a.	NOUN
admet-2626	519	6	avdeef	avdeef	PROPN
admet-2626	519	7	.	.	PUNCT
admet-2626	520	1	cocrystal	cocrystal	PROPN
admet-2626	520	2	solubility	solubility	NOUN
admet-2626	520	3	-	-	PUNCT
admet-2626	520	4	ph	ph	ADJ
admet-2626	520	5	and	and	CCONJ
admet-2626	520	6	drug	drug	NOUN
admet-2626	520	7	solubilization	solubilization	NOUN
admet-2626	520	8	capacity	capacity	NOUN
admet-2626	520	9	of	of	ADP
admet-2626	520	10	sodium	sodium	NOUN
admet-2626	520	11	dodecyl	dodecyl	PROPN
admet-2626	520	12	sulfate	sulfate	VERB
admet-2626	520	13	mass	mass	NOUN
admet-2626	520	14	action	action	NOUN
admet-2626	520	15	model	model	NOUN
admet-2626	520	16	for	for	ADP
admet-2626	520	17	data	datum	NOUN
admet-2626	520	18	analysis	analysis	NOUN
admet-2626	520	19	and	and	CCONJ
admet-2626	520	20	simulation	simulation	NOUN
admet-2626	520	21	to	to	PART
admet-2626	520	22	improve	improve	VERB
admet-2626	520	23	design	design	NOUN
admet-2626	520	24	of	of	ADP
admet-2626	520	25	experiments	experiment	NOUN
admet-2626	520	26	.	.	PUNCT
admet-2626	521	1	admet	admet	PROPN
admet-2626	521	2	&	&	CCONJ
admet-2626	521	3	dmpk	dmpk	PROPN
admet-2626	521	4	6	6	NUM
admet-2626	521	5	(	(	PUNCT
admet-2626	521	6	2018	2018	NUM
admet-2626	521	7	)	)	PUNCT
admet-2626	521	8	105	105	NUM
admet-2626	521	9	-	-	SYM
admet-2626	521	10	139	139	NUM
admet-2626	521	11	.	.	PUNCT
admet-2626	522	1	https://doi.org/10.5599/admet.505	https://doi.org/10.5599/admet.505	X
admet-2626	523	1	[	[	X
admet-2626	523	2	48	48	NUM
admet-2626	523	3	]	]	PUNCT
admet-2626	523	4	a.	a.	NOUN
admet-2626	523	5	avdeef	avdeef	PROPN
admet-2626	523	6	.	.	PUNCT
admet-2626	524	1	cocrystal	cocrystal	PROPN
admet-2626	524	2	solubility	solubility	NOUN
admet-2626	524	3	product	product	NOUN
admet-2626	524	4	prediction	prediction	NOUN
admet-2626	524	5	using	use	VERB
admet-2626	524	6	an	an	DET
admet-2626	524	7	in	in	ADP
admet-2626	524	8	combo	combo	NOUN
admet-2626	524	9	model	model	NOUN
admet-2626	524	10	and	and	CCONJ
admet-2626	524	11	simulations	simulation	NOUN
admet-2626	524	12	to	to	PART
admet-2626	524	13	improve	improve	VERB
admet-2626	524	14	design	design	NOUN
admet-2626	524	15	of	of	ADP
admet-2626	524	16	experiments	experiment	NOUN
admet-2626	524	17	.	.	PUNCT
admet-2626	525	1	pharmaceutical	pharmaceutical	ADJ
admet-2626	525	2	research	research	NOUN
admet-2626	525	3	35	35	NUM
admet-2626	525	4	(	(	PUNCT
admet-2626	525	5	2018	2018	NUM
admet-2626	525	6	)	)	PUNCT
admet-2626	525	7	40	40	NUM
admet-2626	525	8	.	.	PUNCT
admet-2626	526	1	https://doi.org/10.1007/s11095-018-2343-3	https://doi.org/10.1007/s11095-018-2343-3	PRON
admet-2626	527	1	[	[	X
admet-2626	527	2	49	49	NUM
admet-2626	527	3	]	]	X
admet-2626	527	4	o.s	o.s	PROPN
admet-2626	527	5	.	.	PROPN
admet-2626	527	6	marković	marković	PROPN
admet-2626	527	7	,	,	PUNCT
admet-2626	527	8	m.p	m.p	PROPN
admet-2626	527	9	.	.	PROPN
admet-2626	527	10	pešić	pešić	PROPN
admet-2626	527	11	,	,	PUNCT
admet-2626	527	12	a.v	a.v	PROPN
admet-2626	527	13	.	.	PROPN
admet-2626	527	14	shah	shah	PROPN
admet-2626	527	15	,	,	PUNCT
admet-2626	527	16	a.t.m	a.t.m	PROPN
admet-2626	527	17	.	.	PUNCT
admet-2626	528	1	serajuddin	serajuddin	PROPN
admet-2626	528	2	,	,	PUNCT
admet-2626	528	3	t.	t.	PROPN
admet-2626	528	4	ž	ž	PROPN
admet-2626	528	5	.	.	PROPN
admet-2626	528	6	verbić	verbić	PROPN
admet-2626	528	7	,	,	PUNCT
admet-2626	528	8	a.	a.	NOUN
admet-2626	528	9	avdeef	avdeef	PROPN
admet-2626	528	10	.	.	PUNCT
admet-2626	529	1	solubility	solubility	NOUN
admet-2626	529	2	-	-	PUNCT
admet-2626	529	3	ph	ph	NOUN
admet-2626	529	4	profile	profile	NOUN
admet-2626	529	5	of	of	ADP
admet-2626	529	6	desipramine	desipramine	NOUN
admet-2626	529	7	hydrochloride	hydrochloride	NOUN
admet-2626	529	8	in	in	ADP
admet-2626	529	9	saline	saline	ADJ
admet-2626	529	10	phosphate	phosphate	NOUN
admet-2626	529	11	buffer	buffer	NOUN
admet-2626	529	12	:	:	PUNCT
admet-2626	529	13	enhanced	enhance	VERB
admet-2626	529	14	solubility	solubility	NOUN
admet-2626	529	15	due	due	ADP
admet-2626	529	16	to	to	ADP
admet-2626	529	17	drug	drug	NOUN
admet-2626	529	18	-	-	PUNCT
admet-2626	529	19	buffer	buffer	NOUN
admet-2626	529	20	aggregates	aggregate	NOUN
admet-2626	529	21	.	.	PUNCT
admet-2626	530	1	european	european	ADJ
admet-2626	530	2	journal	journal	PROPN
admet-2626	530	3	of	of	ADP
admet-2626	530	4	pharmaceutical	pharmaceutical	PROPN
admet-2626	530	5	sciences	science	NOUN
admet-2626	530	6	133	133	NUM
admet-2626	530	7	(	(	PUNCT
admet-2626	530	8	2019	2019	NUM
admet-2626	530	9	)	)	PUNCT
admet-2626	530	10	264	264	NUM
admet-2626	530	11	-	-	SYM
admet-2626	530	12	274	274	NUM
admet-2626	530	13	.	.	PUNCT
admet-2626	531	1	https://doi.org/10.1016/j.ejps.2019.03.014	https://doi.org/10.1016/j.ejps.2019.03.014	PROPN
admet-2626	531	2	[	[	X
admet-2626	531	3	50	50	NUM
admet-2626	531	4	]	]	X
admet-2626	531	5	o.s	o.s	PROPN
admet-2626	531	6	.	.	PROPN
admet-2626	531	7	marković	marković	PROPN
admet-2626	531	8	,	,	PUNCT
admet-2626	531	9	n.g	n.g	PROPN
admet-2626	531	10	.	.	PROPN
admet-2626	531	11	patel	patel	PROPN
admet-2626	531	12	,	,	PUNCT
admet-2626	531	13	a.t.m	a.t.m	PROPN
admet-2626	531	14	.	.	PUNCT
admet-2626	532	1	serajuddin	serajuddin	PROPN
admet-2626	532	2	,	,	PUNCT
admet-2626	532	3	a.	a.	NOUN
admet-2626	532	4	avdeef	avdeef	PROPN
admet-2626	532	5	,	,	PUNCT
admet-2626	532	6	t.ž	t.ž	PROPN
admet-2626	532	7	.	.	PROPN
admet-2626	532	8	verbić	verbić	PROPN
admet-2626	532	9	.	.	PUNCT
admet-2626	533	1	nortriptyline	nortriptyline	NOUN
admet-2626	533	2	hydrochloride	hydrochloride	NOUN
admet-2626	533	3	solubility	solubility	NOUN
admet-2626	533	4	-	-	PUNCT
admet-2626	533	5	ph	ph	ADJ
admet-2626	533	6	profiles	profile	NOUN
admet-2626	533	7	in	in	ADP
admet-2626	533	8	a	a	DET
admet-2626	533	9	saline	saline	ADJ
admet-2626	533	10	phosphate	phosphate	NOUN
admet-2626	533	11	buffer	buffer	NOUN
admet-2626	533	12	:	:	PUNCT
admet-2626	533	13	drug	drug	NOUN
admet-2626	533	14	-	-	PUNCT
admet-2626	533	15	phosphate	phosphate	NOUN
admet-2626	533	16	complexes	complex	NOUN
admet-2626	533	17	and	and	CCONJ
admet-2626	533	18	multiple	multiple	ADJ
admet-2626	533	19	phmax	phmax	ADJ
admet-2626	533	20	domains	domain	NOUN
admet-2626	533	21	with	with	ADP
admet-2626	533	22	a	a	DET
admet-2626	533	23	gibbs	gibbs	PROPN
admet-2626	533	24	phase	phase	NOUN
admet-2626	533	25	rule	rule	NOUN
admet-2626	533	26	‘	'	PUNCT
admet-2626	533	27	soft	soft	ADJ
admet-2626	533	28	’	'	PUNCT
admet-2626	533	29	constraints	constraint	NOUN
admet-2626	533	30	.	.	PUNCT
admet-2626	534	1	molecular	molecular	ADJ
admet-2626	534	2	pharmaceutics	pharmaceutic	NOUN
admet-2626	534	3	19	19	NUM
admet-2626	534	4	(	(	PUNCT
admet-2626	534	5	2022	2022	NUM
admet-2626	534	6	)	)	PUNCT
admet-2626	534	7	710	710	NUM
admet-2626	534	8	-	-	SYM
admet-2626	534	9	719	719	NUM
admet-2626	534	10	.	.	PUNCT
admet-2626	534	11	https://doi.org/10.1021/acs.molpharmaceut.1c00919	https://doi.org/10.1021/acs.molpharmaceut.1c00919	PRON
admet-2626	535	1	[	[	X
admet-2626	535	2	51	51	NUM
admet-2626	535	3	]	]	PUNCT
admet-2626	535	4	a.	a.	NOUN
admet-2626	535	5	avdeef	avdeef	PROPN
admet-2626	535	6	.	.	PUNCT
admet-2626	535	7	disproportionation	disproportionation	NOUN
admet-2626	535	8	of	of	ADP
admet-2626	535	9	pharmaceutical	pharmaceutical	ADJ
admet-2626	535	10	salts	salt	NOUN
admet-2626	535	11	:	:	PUNCT
admet-2626	535	12	phmax	phmax	ADJ
admet-2626	535	13	and	and	CCONJ
admet-2626	535	14	phase	phase	NOUN
admet-2626	535	15	-	-	PUNCT
admet-2626	535	16	solubility	solubility	NOUN
admet-2626	535	17	/	/	SYM
admet-2626	535	18	ph	ph	NOUN
admet-2626	535	19	variance	variance	NOUN
admet-2626	535	20	.	.	PUNCT
admet-2626	536	1	molecular	molecular	ADJ
admet-2626	536	2	pharmaceutics	pharmaceutic	NOUN
admet-2626	536	3	18	18	NUM
admet-2626	536	4	(	(	PUNCT
admet-2626	536	5	2021	2021	NUM
admet-2626	536	6	)	)	PUNCT
admet-2626	536	7	2724	2724	NUM
admet-2626	536	8	-	-	SYM
admet-2626	536	9	2743	2743	NUM
admet-2626	536	10	.	.	PUNCT
admet-2626	537	1	https://doi.org/10.1021/acs.molpharmaceut.1c00258	https://doi.org/10.1021/acs.molpharmaceut.1c00258	VERB
admet-2626	537	2	https://doi.org/10.1021/ic50196a045	https://doi.org/10.1021/ic50196a045	PROPN
admet-2626	537	3	https://doi.org/10.1002/jps.2600820214	https://doi.org/10.1002/jps.2600820214	PROPN
admet-2626	537	4	https://doi.org/10.1111/j.2042-7158.1998.tb00328.x	https://doi.org/10.1111/j.2042-7158.1998.tb00328.x	PROPN
admet-2626	537	5	https://doi.org/10.1016/j.addr.2007.05.008	https://doi.org/10.1016/j.addr.2007.05.008	NOUN
admet-2626	537	6	http://dx.doi.org/10.5599/admet.686	http://dx.doi.org/10.5599/admet.686	ADJ
admet-2626	537	7	https://doi.org/10.5599/admet.1.4.24	https://doi.org/10.5599/admet.1.4.24	NOUN
admet-2626	537	8	https://doi.org/10.1021/acs.molpharmaceut.1c00131	https://doi.org/10.1021/acs.molpharmaceut.1c00131	NOUN
admet-2626	537	9	https://doi.org/10.5599/admet.2.1.30	https://doi.org/10.5599/admet.2.1.30	VERB
admet-2626	537	10	https://doi.org/10.5599/admet.2.1.31	https://doi.org/10.5599/admet.2.1.31	PROPN
admet-2626	537	11	https://doi.org/10.5599/admet.3.2.182	https://doi.org/10.5599/admet.3.2.182	PROPN
admet-2626	537	12	https://doi.org/10.3390/pharmaceutics14010182	https://doi.org/10.3390/pharmaceutics14010182	NOUN
admet-2626	537	13	https://doi.org/10.1016/j.ejps.2017.03.049	https://doi.org/10.1016/j.ejps.2017.03.049	NOUN
admet-2626	537	14	https://doi.org/10.5599/admet.505	https://doi.org/10.5599/admet.505	NUM
admet-2626	537	15	https://doi.org/10.1007/s11095-018-2343-3	https://doi.org/10.1007/s11095-018-2343-3	PROPN
admet-2626	537	16	https://doi.org/10.1016/j.ejps.2019.03.014	https://doi.org/10.1016/j.ejps.2019.03.014	PROPN
admet-2626	537	17	https://doi.org/10.1021/acs.molpharmaceut.1c00919	https://doi.org/10.1021/acs.molpharmaceut.1c00919	NUM
admet-2626	537	18	https://doi.org/10.1021/acs.molpharmaceut.1c00258	https://doi.org/10.1021/acs.molpharmaceut.1c00258	PROPN
admet-2626	537	19	admet	admet	PROPN
admet-2626	537	20	&	&	CCONJ
admet-2626	537	21	dmpk	dmpk	PROPN
admet-2626	537	22	13(1	13(1	NUM
admet-2626	537	23	)	)	PUNCT
admet-2626	537	24	(	(	PUNCT
admet-2626	537	25	2025	2025	NUM
admet-2626	537	26	)	)	PUNCT
admet-2626	537	27	2626	2626	NUM
admet-2626	537	28	transforming	transform	VERB
admet-2626	537	29	drug	drug	NOUN
admet-2626	537	30	solubility	solubility	NOUN
admet-2626	537	31	measurement	measurement	NOUN
admet-2626	537	32	doi	doi	PROPN
admet-2626	537	33	:	:	PUNCT
admet-2626	537	34	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	NOUN
admet-2626	537	35	17	17	NUM
admet-2626	537	36	[	[	X
admet-2626	537	37	52	52	NUM
admet-2626	537	38	]	]	PUNCT
admet-2626	537	39	a.	a.	NOUN
admet-2626	537	40	avdeef	avdeef	PROPN
admet-2626	537	41	,	,	PUNCT
admet-2626	537	42	k.	k.	PROPN
admet-2626	537	43	sugano	sugano	PROPN
admet-2626	537	44	.	.	PUNCT
admet-2626	538	1	salt	salt	NOUN
admet-2626	538	2	solubility	solubility	NOUN
admet-2626	538	3	and	and	CCONJ
admet-2626	538	4	disproportionation	disproportionation	NOUN
admet-2626	538	5	uses	use	NOUN
admet-2626	538	6	and	and	CCONJ
admet-2626	538	7	limitations	limitation	NOUN
admet-2626	538	8	of	of	ADP
admet-2626	538	9	equations	equation	NOUN
admet-2626	538	10	for	for	ADP
admet-2626	538	11	phmax	phmax	NOUN
admet-2626	538	12	and	and	CCONJ
admet-2626	538	13	the	the	DET
admet-2626	538	14	in	in	ADP
admet-2626	538	15	-	-	PUNCT
admet-2626	538	16	silico	silico	NOUN
admet-2626	538	17	prediction	prediction	NOUN
admet-2626	538	18	of	of	ADP
admet-2626	538	19	phmax	phmax	PROPN
admet-2626	538	20	.	.	PUNCT
admet-2626	539	1	journal	journal	PROPN
admet-2626	539	2	of	of	ADP
admet-2626	539	3	pharmaceutical	pharmaceutical	PROPN
admet-2626	539	4	sciences	science	NOUN
admet-2626	539	5	111	111	NUM
admet-2626	539	6	(	(	PUNCT
admet-2626	539	7	2022	2022	NUM
admet-2626	539	8	)	)	PUNCT
admet-2626	539	9	225	225	NUM
admet-2626	539	10	-	-	SYM
admet-2626	539	11	246	246	NUM
admet-2626	539	12	.	.	PUNCT
admet-2626	540	1	https://doi.org/10.1016/j.xphs.2021.11.017	https://doi.org/10.1016/j.xphs.2021.11.017	PROPN
admet-2626	540	2	[	[	X
admet-2626	540	3	53	53	NUM
admet-2626	540	4	]	]	X
admet-2626	540	5	r.a	r.a	PROPN
admet-2626	540	6	.	.	PROPN
admet-2626	540	7	robinson	robinson	PROPN
admet-2626	540	8	,	,	PUNCT
admet-2626	540	9	r.h	r.h	PROPN
admet-2626	540	10	.	.	PROPN
admet-2626	540	11	stokes	stokes	PROPN
admet-2626	540	12	.	.	PUNCT
admet-2626	541	1	electrolytic	electrolytic	ADJ
admet-2626	541	2	solutions	solution	NOUN
admet-2626	541	3	.	.	PUNCT
admet-2626	542	1	2nd	2nd	PROPN
admet-2626	542	2	rev	rev	PROPN
admet-2626	542	3	.	.	PUNCT
admet-2626	543	1	ed	ed	PROPN
admet-2626	543	2	.	.	PUNCT
admet-2626	543	3	dover	dover	PROPN
admet-2626	543	4	publications	publications	PROPN
admet-2626	543	5	,	,	PUNCT
admet-2626	543	6	inc	inc	PROPN
admet-2626	543	7	.	.	PROPN
admet-2626	543	8	,	,	PUNCT
admet-2626	543	9	mineola	mineola	PROPN
admet-2626	543	10	,	,	PUNCT
admet-2626	543	11	ny	ny	PROPN
admet-2626	543	12	.	.	PROPN
admet-2626	543	13	2002	2002	NUM
admet-2626	543	14	,	,	PUNCT
admet-2626	543	15	pp	pp	ADJ
admet-2626	543	16	.	.	PUNCT
admet-2626	544	1	18	18	NUM
admet-2626	544	2	-	-	SYM
admet-2626	544	3	19	19	NUM
admet-2626	544	4	.	.	PUNCT
admet-2626	545	1	https://easypdfs.cloud/downloads/4879156-electrolyte-solutions-robinson-stokes	https://easypdfs.cloud/downloads/4879156-electrolyte-solutions-robinson-stoke	NOUN
admet-2626	546	1	[	[	X
admet-2626	546	2	54	54	NUM
admet-2626	546	3	]	]	SYM
admet-2626	546	4	r.g	r.g	PROPN
admet-2626	546	5	.	.	PROPN
admet-2626	546	6	bates	bates	PROPN
admet-2626	546	7	,	,	PUNCT
admet-2626	546	8	b.r	b.r	PROPN
admet-2626	546	9	.	.	PROPN
admet-2626	546	10	staples	staple	NOUN
admet-2626	546	11	,	,	PUNCT
admet-2626	546	12	r.a	r.a	PROPN
admet-2626	546	13	.	.	PROPN
admet-2626	546	14	robinson	robinson	PROPN
admet-2626	546	15	.	.	PUNCT
admet-2626	547	1	ionic	ionic	ADJ
admet-2626	547	2	hydration	hydration	NOUN
admet-2626	547	3	and	and	CCONJ
admet-2626	547	4	single	single	ADJ
admet-2626	547	5	ion	ion	NOUN
admet-2626	547	6	activities	activity	NOUN
admet-2626	547	7	in	in	ADP
admet-2626	547	8	unassociated	unassociated	ADJ
admet-2626	547	9	chlorides	chloride	NOUN
admet-2626	547	10	at	at	ADP
admet-2626	547	11	high	high	ADJ
admet-2626	547	12	ionic	ionic	ADJ
admet-2626	547	13	strengths	strength	NOUN
admet-2626	547	14	.	.	PUNCT
admet-2626	548	1	analytical	analytical	ADJ
admet-2626	548	2	chemistry	chemistry	NOUN
admet-2626	548	3	42	42	NUM
admet-2626	548	4	(	(	PUNCT
admet-2626	548	5	1970	1970	NUM
admet-2626	548	6	)	)	PUNCT
admet-2626	548	7	867	867	NUM
admet-2626	548	8	-	-	SYM
admet-2626	548	9	871	871	NUM
admet-2626	548	10	.	.	PUNCT
admet-2626	549	1	https://doi.org/10.1021/ac60290a006	https://doi.org/10.1021/ac60290a006	PROPN
admet-2626	549	2	[	[	X
admet-2626	549	3	55	55	NUM
admet-2626	549	4	]	]	X
admet-2626	549	5	r.a	r.a	PROPN
admet-2626	549	6	.	.	PROPN
admet-2626	549	7	robinson	robinson	PROPN
admet-2626	549	8	,	,	PUNCT
admet-2626	549	9	r.g	r.g	PROPN
admet-2626	549	10	.	.	PROPN
admet-2626	549	11	bates	bate	NOUN
admet-2626	549	12	.	.	PUNCT
admet-2626	550	1	ionic	ionic	ADJ
admet-2626	550	2	activity	activity	NOUN
admet-2626	550	3	coefficients	coefficient	NOUN
admet-2626	550	4	in	in	ADP
admet-2626	550	5	aqueous	aqueous	ADJ
admet-2626	550	6	mixtures	mixture	NOUN
admet-2626	550	7	of	of	ADP
admet-2626	550	8	nacl	nacl	NOUN
admet-2626	550	9	and	and	CCONJ
admet-2626	550	10	mgcl2	mgcl2	PROPN
admet-2626	550	11	.	.	PUNCT
admet-2626	551	1	marine	marine	PROPN
admet-2626	551	2	chemistry	chemistry	NOUN
admet-2626	551	3	6	6	NUM
admet-2626	551	4	(	(	PUNCT
admet-2626	551	5	1978	1978	NUM
admet-2626	551	6	)	)	PUNCT
admet-2626	551	7	327	327	NUM
admet-2626	551	8	-	-	SYM
admet-2626	551	9	333	333	NUM
admet-2626	551	10	.	.	PUNCT
admet-2626	552	1	https://doi.org/10.1016/0304-4203(78)90013-0	https://doi.org/10.1016/0304-4203(78)90013-0	ADJ
admet-2626	552	2	[	[	X
admet-2626	552	3	56	56	NUM
admet-2626	552	4	]	]	X
admet-2626	552	5	j.p	j.p	PROPN
admet-2626	552	6	.	.	PROPN
admet-2626	552	7	amend	amend	PROPN
admet-2626	552	8	,	,	PUNCT
admet-2626	552	9	h.c	h.c	PROPN
admet-2626	552	10	.	.	PROPN
admet-2626	552	11	helgeson	helgeson	PROPN
admet-2626	552	12	.	.	PUNCT
admet-2626	553	1	solubilities	solubility	NOUN
admet-2626	553	2	of	of	ADP
admet-2626	553	3	the	the	DET
admet-2626	553	4	common	common	ADJ
admet-2626	553	5	l	l	PROPN
admet-2626	553	6	-	-	ADJ
admet-2626	553	7	α	α	ADJ
admet-2626	553	8	-	-	ADJ
admet-2626	553	9	amino	amino	ADJ
admet-2626	553	10	acids	acid	NOUN
admet-2626	553	11	as	as	ADP
admet-2626	553	12	a	a	DET
admet-2626	553	13	function	function	NOUN
admet-2626	553	14	of	of	ADP
admet-2626	553	15	temperature	temperature	NOUN
admet-2626	553	16	and	and	CCONJ
admet-2626	553	17	solution	solution	NOUN
admet-2626	553	18	ph	ph	VERB
admet-2626	553	19	.	.	PROPN
admet-2626	553	20	pure	pure	ADJ
admet-2626	553	21	and	and	CCONJ
admet-2626	553	22	applied	apply	VERB
admet-2626	553	23	chemistry	chemistry	NOUN
admet-2626	553	24	69	69	NUM
admet-2626	553	25	(	(	PUNCT
admet-2626	553	26	1997	1997	NUM
admet-2626	553	27	)	)	PUNCT
admet-2626	553	28	935	935	NUM
admet-2626	553	29	-	-	SYM
admet-2626	553	30	942	942	NUM
admet-2626	553	31	.	.	PUNCT
admet-2626	554	1	https://doi.org/10.1351/pac199769050935	https://doi.org/10.1351/pac199769050935	X
admet-2626	555	1	[	[	X
admet-2626	555	2	57	57	NUM
admet-2626	555	3	]	]	PUNCT
admet-2626	555	4	t.	t.	PROPN
admet-2626	555	5	zhang	zhang	PROPN
admet-2626	555	6	,	,	PUNCT
admet-2626	555	7	a.	a.	PROPN
admet-2626	555	8	dravid	dravid	PROPN
admet-2626	555	9	,	,	PUNCT
admet-2626	555	10	j.	j.	PROPN
admet-2626	555	11	reddy	reddy	PROPN
admet-2626	555	12	,	,	PUNCT
admet-2626	555	13	l.	l.	PROPN
admet-2626	555	14	aliyu	aliyu	PROPN
admet-2626	555	15	,	,	PUNCT
admet-2626	555	16	j.	j.	PROPN
admet-2626	555	17	park	park	PROPN
admet-2626	555	18	,	,	PUNCT
admet-2626	555	19	z.	z.	PROPN
admet-2626	555	20	wang	wang	PROPN
admet-2626	555	21	,	,	PUNCT
admet-2626	555	22	k.-w	k.-w	PROPN
admet-2626	555	23	.	.	PUNCT
admet-2626	555	24	huang	huang	PROPN
admet-2626	555	25	,	,	PUNCT
admet-2626	555	26	j.	j.	PROPN
admet-2626	555	27	wu	wu	PROPN
admet-2626	555	28	,	,	PUNCT
admet-2626	555	29	s.	s.	PROPN
admet-2626	555	30	liu	liu	PROPN
admet-2626	555	31	,	,	PUNCT
admet-2626	555	32	a.	a.	NOUN
admet-2626	555	33	stone	stone	PROPN
admet-2626	555	34	,	,	PUNCT
admet-2626	555	35	m.	m.	NOUN
admet-2626	555	36	betenbaugh	betenbaugh	PROPN
admet-2626	555	37	,	,	PUNCT
admet-2626	555	38	m.	m.	NOUN
admet-2626	555	39	donohue	donohue	PROPN
admet-2626	555	40	.	.	PUNCT
admet-2626	556	1	modeling	model	VERB
admet-2626	556	2	solubilities	solubility	NOUN
admet-2626	556	3	for	for	ADP
admet-2626	556	4	amino	amino	ADJ
admet-2626	556	5	acids	acid	NOUN
admet-2626	556	6	in	in	ADP
admet-2626	556	7	water	water	NOUN
admet-2626	556	8	as	as	ADP
admet-2626	556	9	functions	function	NOUN
admet-2626	556	10	of	of	ADP
admet-2626	556	11	temperature	temperature	NOUN
admet-2626	556	12	and	and	CCONJ
admet-2626	556	13	ph	ph	ADJ
admet-2626	556	14	.	.	PROPN
admet-2626	556	15	industrial	industrial	PROPN
admet-2626	556	16	&	&	CCONJ
admet-2626	556	17	engineering	engineering	PROPN
admet-2626	556	18	chemistry	chemistry	NOUN
admet-2626	556	19	research	research	NOUN
admet-2626	556	20	63	63	NUM
admet-2626	556	21	(	(	PUNCT
admet-2626	556	22	2024	2024	NUM
admet-2626	556	23	)	)	PUNCT
admet-2626	556	24	22076	22076	NUM
admet-2626	556	25	-	-	SYM
admet-2626	556	26	22086	22086	NUM
admet-2626	556	27	.	.	PUNCT
admet-2626	557	1	https://doi.org/10.1021/acs.iecr.3c00365	https://doi.org/10.1021/acs.iecr.3c00365	PRON
admet-2626	558	1	[	[	X
admet-2626	558	2	58	58	NUM
admet-2626	558	3	]	]	SYM
admet-2626	558	4	j.o’.m	j.o’.m	PROPN
admet-2626	558	5	.	.	PUNCT
admet-2626	559	1	bockris	bockris	PROPN
admet-2626	559	2	,	,	PUNCT
admet-2626	559	3	a.k.n	a.k.n	PROPN
admet-2626	559	4	.	.	PUNCT
admet-2626	559	5	reddy	reddy	PROPN
admet-2626	559	6	.	.	PUNCT
admet-2626	560	1	modern	modern	ADJ
admet-2626	560	2	electrochemistry	electrochemistry	NOUN
admet-2626	560	3	,	,	PUNCT
admet-2626	560	4	vol	vol	NOUN
admet-2626	560	5	.	.	NOUN
admet-2626	560	6	1	1	NUM
admet-2626	560	7	.	.	PUNCT
admet-2626	561	1	plenum	plenum	PROPN
admet-2626	561	2	publishing	publishing	PROPN
admet-2626	561	3	corp	corp	PROPN
admet-2626	561	4	.	.	PROPN
admet-2626	561	5	,	,	PUNCT
admet-2626	561	6	new	new	PROPN
admet-2626	561	7	york	york	PROPN
admet-2626	561	8	,	,	PUNCT
admet-2626	561	9	ny	ny	PROPN
admet-2626	561	10	,	,	PUNCT
admet-2626	561	11	1973	1973	NUM
admet-2626	561	12	.	.	PUNCT
admet-2626	562	1	https://doi.org/10.1007/b114546	https://doi.org/10.1007/b114546	NUM
admet-2626	562	2	[	[	SYM
admet-2626	562	3	59	59	NUM
admet-2626	562	4	]	]	PUNCT
admet-2626	562	5	j.	j.	PROPN
admet-2626	562	6	kielland	kielland	PROPN
admet-2626	562	7	.	.	PUNCT
admet-2626	563	1	individual	individual	ADJ
admet-2626	563	2	activity	activity	NOUN
admet-2626	563	3	coefficients	coefficient	NOUN
admet-2626	563	4	of	of	ADP
admet-2626	563	5	ions	ion	NOUN
admet-2626	563	6	in	in	ADP
admet-2626	563	7	aqueous	aqueous	ADJ
admet-2626	563	8	solutions	solution	NOUN
admet-2626	563	9	.	.	PUNCT
admet-2626	564	1	journal	journal	NOUN
admet-2626	564	2	of	of	ADP
admet-2626	564	3	the	the	DET
admet-2626	564	4	american	american	PROPN
admet-2626	564	5	chemical	chemical	PROPN
admet-2626	564	6	society	society	PROPN
admet-2626	564	7	59	59	NUM
admet-2626	564	8	(	(	PUNCT
admet-2626	564	9	1937	1937	NUM
admet-2626	564	10	)	)	PUNCT
admet-2626	564	11	1675	1675	NUM
admet-2626	564	12	-	-	SYM
admet-2626	564	13	1678	1678	NUM
admet-2626	564	14	.	.	PUNCT
admet-2626	565	1	https://doi.org/10.1021/ja01288a032	https://doi.org/10.1021/ja01288a032	NOUN
admet-2626	565	2	.	.	PUNCT
admet-2626	566	1	[	[	X
admet-2626	566	2	60	60	NUM
admet-2626	566	3	]	]	X
admet-2626	566	4	n.	n.	PROPN
admet-2626	566	5	ni	ni	PROPN
admet-2626	566	6	,	,	PUNCT
admet-2626	566	7	s.h	s.h	PROPN
admet-2626	566	8	.	.	NOUN
admet-2626	566	9	yalkowsky	yalkowsky	ADJ
admet-2626	566	10	.	.	PUNCT
admet-2626	567	1	prediction	prediction	NOUN
admet-2626	567	2	of	of	ADP
admet-2626	567	3	setschenow	setschenow	NOUN
admet-2626	567	4	constants	constant	NOUN
admet-2626	567	5	.	.	PUNCT
admet-2626	568	1	international	international	ADJ
admet-2626	568	2	journal	journal	PROPN
admet-2626	568	3	of	of	ADP
admet-2626	568	4	pharmaceutics	pharmaceutic	NOUN
admet-2626	568	5	254	254	NUM
admet-2626	568	6	(	(	PUNCT
admet-2626	568	7	2003	2003	NUM
admet-2626	568	8	)	)	PUNCT
admet-2626	568	9	167	167	NUM
admet-2626	568	10	-	-	SYM
admet-2626	568	11	172	172	NUM
admet-2626	568	12	.	.	PUNCT
admet-2626	568	13	https://doi.org/10.1016/s0378-5173(03)00008-5	https://doi.org/10.1016/s0378-5173(03)00008-5	PROPN
admet-2626	569	1	[	[	X
admet-2626	569	2	61	61	NUM
admet-2626	569	3	]	]	X
admet-2626	569	4	j.a	j.a	PROPN
admet-2626	569	5	.	.	PROPN
admet-2626	569	6	platts	platts	PROPN
admet-2626	569	7	,	,	PUNCT
admet-2626	569	8	d.	d.	PROPN
admet-2626	569	9	butina	butina	PROPN
admet-2626	569	10	,	,	PUNCT
admet-2626	569	11	m.h	m.h	PROPN
admet-2626	569	12	.	.	PROPN
admet-2626	569	13	abraham	abraham	PROPN
admet-2626	569	14	,	,	PUNCT
admet-2626	569	15	a.	a.	PROPN
admet-2626	569	16	hersey	hersey	PROPN
admet-2626	569	17	.	.	PUNCT
admet-2626	570	1	estimation	estimation	NOUN
admet-2626	570	2	of	of	ADP
admet-2626	570	3	molecular	molecular	ADJ
admet-2626	570	4	linear	linear	ADJ
admet-2626	570	5	free	free	ADJ
admet-2626	570	6	energy	energy	NOUN
admet-2626	570	7	relation	relation	NOUN
admet-2626	570	8	descriptors	descriptor	NOUN
admet-2626	570	9	using	use	VERB
admet-2626	570	10	a	a	DET
admet-2626	570	11	group	group	NOUN
admet-2626	570	12	contribution	contribution	NOUN
admet-2626	570	13	approach	approach	NOUN
admet-2626	570	14	.	.	PUNCT
admet-2626	571	1	journal	journal	PROPN
admet-2626	571	2	of	of	ADP
admet-2626	571	3	chemical	chemical	ADJ
admet-2626	571	4	information	information	NOUN
admet-2626	571	5	and	and	CCONJ
admet-2626	571	6	computer	computer	NOUN
admet-2626	571	7	sciences	science	NOUN
admet-2626	571	8	39	39	NUM
admet-2626	571	9	(	(	PUNCT
admet-2626	571	10	1999	1999	NUM
admet-2626	571	11	)	)	PUNCT
admet-2626	571	12	835	835	NUM
admet-2626	571	13	-	-	SYM
admet-2626	571	14	845	845	NUM
admet-2626	571	15	.	.	PUNCT
admet-2626	572	1	https://doi.org/10.1021/ci980339	https://doi.org/10.1021/ci980339	PROPN
admet-2626	572	2	t	t	PROPN
admet-2626	572	3	[	[	X
admet-2626	572	4	62	62	NUM
admet-2626	572	5	]	]	X
admet-2626	572	6	f.h	f.h	PROPN
admet-2626	572	7	.	.	PROPN
admet-2626	572	8	sweeton	sweeton	PROPN
admet-2626	572	9	,	,	PUNCT
admet-2626	572	10	r.e	r.e	PROPN
admet-2626	572	11	.	.	PROPN
admet-2626	572	12	mesmer	mesmer	PROPN
admet-2626	572	13	,	,	PUNCT
admet-2626	572	14	c.f	c.f	PROPN
admet-2626	572	15	.	.	PROPN
admet-2626	572	16	baes	baes	PROPN
admet-2626	572	17	,	,	PUNCT
admet-2626	572	18	jr	jr	PROPN
admet-2626	572	19	.	.	PROPN
admet-2626	572	20	acidity	acidity	NOUN
admet-2626	572	21	measurements	measurement	NOUN
admet-2626	572	22	at	at	ADP
admet-2626	572	23	elevated	elevated	ADJ
admet-2626	572	24	temperatures	temperature	NOUN
admet-2626	572	25	.	.	PUNCT
admet-2626	573	1	vii	vii	PROPN
admet-2626	573	2	.	.	PROPN
admet-2626	573	3	dissociation	dissociation	NOUN
admet-2626	573	4	of	of	ADP
admet-2626	573	5	water	water	NOUN
admet-2626	573	6	.	.	PUNCT
admet-2626	574	1	journal	journal	NOUN
admet-2626	574	2	of	of	ADP
admet-2626	574	3	solution	solution	NOUN
admet-2626	574	4	chemistry	chemistry	NOUN
admet-2626	574	5	3	3	NUM
admet-2626	574	6	(	(	PUNCT
admet-2626	574	7	1974	1974	NUM
admet-2626	574	8	)	)	PUNCT
admet-2626	574	9	191	191	NUM
admet-2626	574	10	-	-	SYM
admet-2626	574	11	214	214	NUM
admet-2626	574	12	.	.	PUNCT
admet-2626	575	1	https://doi.org/10.1007/bf00645633	https://doi.org/10.1007/bf00645633	X
admet-2626	575	2	.	.	PUNCT
admet-2626	576	1	©	©	PROPN
admet-2626	576	2	2025	2025	NUM
admet-2626	576	3	by	by	ADP
admet-2626	576	4	the	the	DET
admet-2626	576	5	authors	author	NOUN
admet-2626	576	6	;	;	PUNCT
admet-2626	576	7	licensee	licensee	PROPN
admet-2626	576	8	iapc	iapc	PROPN
admet-2626	576	9	,	,	PUNCT
admet-2626	576	10	zagreb	zagreb	PROPN
admet-2626	576	11	,	,	PUNCT
admet-2626	576	12	croatia	croatia	PROPN
admet-2626	576	13	.	.	PUNCT
admet-2626	577	1	this	this	DET
admet-2626	577	2	article	article	NOUN
admet-2626	577	3	is	be	AUX
admet-2626	577	4	an	an	DET
admet-2626	577	5	open	open	ADJ
admet-2626	577	6	-	-	PUNCT
admet-2626	577	7	access	access	NOUN
admet-2626	577	8	article	article	NOUN
admet-2626	577	9	distributed	distribute	VERB
admet-2626	577	10	under	under	ADP
admet-2626	577	11	the	the	DET
admet-2626	577	12	terms	term	NOUN
admet-2626	577	13	and	and	CCONJ
admet-2626	577	14	conditions	condition	NOUN
admet-2626	577	15	of	of	ADP
admet-2626	577	16	the	the	DET
admet-2626	577	17	creative	creative	ADJ
admet-2626	577	18	commons	common	NOUN
admet-2626	577	19	attribution	attribution	NOUN
admet-2626	577	20	license	license	NOUN
admet-2626	577	21	(	(	PUNCT
admet-2626	577	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-2626	577	23	)	)	PUNCT
admet-2626	577	24	https://doi.org/10.5599/admet.2626	https://doi.org/10.5599/admet.2626	PROPN
admet-2626	577	25	https://doi.org/10.1016/j.xphs.2021.11.017	https://doi.org/10.1016/j.xphs.2021.11.017	PROPN
admet-2626	577	26	https://easypdfs.cloud/downloads/4879156-electrolyte-solutions-robinson-stokes	https://easypdfs.cloud/downloads/4879156-electrolyte-solutions-robinson-stoke	NOUN
admet-2626	577	27	https://doi.org/10.1021/ac60290a006	https://doi.org/10.1021/ac60290a006	PROPN
admet-2626	577	28	https://doi.org/10.1016/0304-4203(78)90013-0	https://doi.org/10.1016/0304-4203(78)90013-0	X
admet-2626	577	29	https://doi.org/10.1351/pac199769050935	https://doi.org/10.1351/pac199769050935	PROPN
admet-2626	577	30	https://doi.org/10.1021/acs.iecr.3c00365	https://doi.org/10.1021/acs.iecr.3c00365	VERB
admet-2626	577	31	https://doi.org/10.1007/b114546	https://doi.org/10.1007/b114546	NUM
admet-2626	577	32	https://doi.org/10.1021/ja01288a032	https://doi.org/10.1021/ja01288a032	PROPN
admet-2626	577	33	https://doi.org/10.1016/s0378-5173(03)00008-5	https://doi.org/10.1016/s0378-5173(03)00008-5	PROPN
admet-2626	578	1	https://doi.org/10.1021/ci980339	https://doi.org/10.1021/ci980339	PROPN
admet-2626	578	2	t	t	PROPN
admet-2626	578	3	https://doi.org/10.1007/bf00645633	https://doi.org/10.1007/bf00645633	PUNCT
admet-2626	578	4	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN