id	sid	tid	token	lemma	pos
admet-275	1	1	manuscript	manuscript	PROPN
admet-275	1	2	doi	doi	PROPN
admet-275	1	3	:	:	PUNCT
admet-275	1	4	10.5599	10.5599	NUM
admet-275	1	5	/	/	SYM
admet-275	1	6	admet.4.1.275	admet.4.1.275	PROPN
admet-275	1	7	23	23	NUM
admet-275	1	8	admet	admet	X
admet-275	1	9	&	&	CCONJ
admet-275	1	10	dmpk	dmpk	PROPN
admet-275	1	11	4(1	4(1	NOUN
admet-275	1	12	)	)	PUNCT
admet-275	1	13	(	(	PUNCT
admet-275	1	14	2016	2016	NUM
admet-275	1	15	)	)	PUNCT
admet-275	1	16	23	23	NUM
admet-275	1	17	-	-	SYM
admet-275	1	18	34	34	NUM
admet-275	1	19	;	;	PUNCT
admet-275	1	20	doi	doi	NOUN
admet-275	1	21	:	:	PUNCT
admet-275	1	22	10.5599	10.5599	NUM
admet-275	1	23	/	/	SYM
admet-275	1	24	admet.4.1.275	admet.4.1.275	NOUN
admet-275	1	25	open	open	ADJ
admet-275	1	26	access	access	NOUN
admet-275	1	27	:	:	PUNCT
admet-275	1	28	issn	issn	PROPN
admet-275	1	29	:	:	PUNCT
admet-275	1	30	1848	1848	NUM
admet-275	1	31	-	-	SYM
admet-275	1	32	7718	7718	NUM
admet-275	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-275	1	34	original	original	ADJ
admet-275	1	35	scientific	scientific	ADJ
admet-275	1	36	paper	paper	NOUN
admet-275	1	37	transport	transport	NOUN
admet-275	1	38	of	of	ADP
admet-275	1	39	six	six	NUM
admet-275	1	40	tyrosine	tyrosine	NOUN
admet-275	1	41	kinase	kinase	NOUN
admet-275	1	42	inhibitors	inhibitor	NOUN
admet-275	1	43	:	:	PUNCT
admet-275	1	44	active	active	ADJ
admet-275	1	45	or	or	CCONJ
admet-275	1	46	passive	passive	ADJ
admet-275	1	47	?	?	PUNCT
admet-275	2	1	richard	richard	PROPN
admet-275	2	2	j.	j.	PROPN
admet-275	2	3	honeywell	honeywell	PROPN
admet-275	2	4	,	,	PUNCT
admet-275	2	5	sarina	sarina	PROPN
admet-275	2	6	hitzerd	hitzerd	PROPN
admet-275	2	7	,	,	PUNCT
admet-275	2	8	ietje	ietje	PROPN
admet-275	2	9	kathmann	kathmann	PROPN
admet-275	2	10	,	,	PUNCT
admet-275	2	11	godefridus	godefridus	PROPN
admet-275	2	12	j.	j.	PROPN
admet-275	2	13	peters	peters	PROPN
admet-275	2	14	*	*	PROPN
admet-275	2	15	department	department	PROPN
admet-275	2	16	of	of	ADP
admet-275	2	17	medical	medical	ADJ
admet-275	2	18	oncology	oncology	NOUN
admet-275	2	19	,	,	PUNCT
admet-275	2	20	vu	vu	PROPN
admet-275	2	21	university	university	PROPN
admet-275	2	22	medical	medical	ADJ
admet-275	2	23	center	center	NOUN
admet-275	2	24	,	,	PUNCT
admet-275	2	25	amsterdam	amsterdam	PROPN
admet-275	2	26	,	,	PUNCT
admet-275	2	27	the	the	DET
admet-275	2	28	netherlands	netherlands	PROPN
admet-275	2	29	*	*	PUNCT
admet-275	2	30	corresponding	correspond	VERB
admet-275	2	31	author	author	NOUN
admet-275	2	32	:	:	PUNCT
admet-275	2	33	e	e	NOUN
admet-275	2	34	-	-	NOUN
admet-275	2	35	mail	mail	NOUN
admet-275	2	36	:	:	PUNCT
admet-275	2	37	gj.peters@vumc.nl	gj.peters@vumc.nl	NOUN
admet-275	2	38	;	;	PUNCT
admet-275	2	39	tel	tel	PROPN
admet-275	2	40	.	.	PUNCT
admet-275	2	41	:	:	PUNCT
admet-275	3	1	+31	+31	NOUN
admet-275	3	2	(	(	PUNCT
admet-275	3	3	20	20	NUM
admet-275	3	4	)	)	PUNCT
admet-275	3	5	444	444	NUM
admet-275	3	6	26	26	NUM
admet-275	3	7	33	33	NUM
admet-275	3	8	received	receive	VERB
admet-275	3	9	:	:	PUNCT
admet-275	3	10	february	february	PROPN
admet-275	3	11	22	22	NUM
admet-275	3	12	,	,	PUNCT
admet-275	3	13	2016	2016	NUM
admet-275	3	14	;	;	PUNCT
admet-275	3	15	published	publish	VERB
admet-275	3	16	:	:	PUNCT
admet-275	3	17	march	march	PROPN
admet-275	3	18	31	31	NUM
admet-275	3	19	,	,	PUNCT
admet-275	3	20	2016	2016	NUM
admet-275	3	21	abstract	abstract	ADJ
admet-275	3	22	transport	transport	NOUN
admet-275	3	23	of	of	ADP
admet-275	3	24	erlotinib	erlotinib	NOUN
admet-275	3	25	,	,	PUNCT
admet-275	3	26	gefitinib	gefitinib	NOUN
admet-275	3	27	,	,	PUNCT
admet-275	3	28	sorafenib	sorafenib	NOUN
admet-275	3	29	,	,	PUNCT
admet-275	3	30	sunitinib	sunitinib	NOUN
admet-275	3	31	,	,	PUNCT
admet-275	3	32	dasatinib	dasatinib	NOUN
admet-275	3	33	and	and	CCONJ
admet-275	3	34	crizotinib	crizotinib	VERB
admet-275	3	35	can	can	AUX
admet-275	3	36	be	be	AUX
admet-275	3	37	active	active	ADJ
admet-275	3	38	or	or	CCONJ
admet-275	3	39	passive	passive	ADJ
admet-275	3	40	,	,	PUNCT
admet-275	3	41	which	which	PRON
admet-275	3	42	was	be	AUX
admet-275	3	43	studied	study	VERB
admet-275	3	44	by	by	ADP
admet-275	3	45	measuring	measure	VERB
admet-275	3	46	uptake	uptake	NOUN
admet-275	3	47	at	at	ADP
admet-275	3	48	low	low	ADJ
admet-275	3	49	(	(	PUNCT
admet-275	3	50	4	4	NUM
admet-275	3	51	°	°	NOUN
admet-275	3	52	c	c	NOUN
admet-275	3	53	;	;	PUNCT
admet-275	3	54	passive	passive	ADJ
admet-275	3	55	)	)	PUNCT
admet-275	3	56	and	and	CCONJ
admet-275	3	57	normal	normal	ADJ
admet-275	3	58	temperature	temperature	NOUN
admet-275	3	59	(	(	PUNCT
admet-275	3	60	37	37	NUM
admet-275	3	61	°	°	NOUN
admet-275	3	62	c	c	NOUN
admet-275	3	63	;	;	PUNCT
admet-275	3	64	active	active	ADJ
admet-275	3	65	and	and	CCONJ
admet-275	3	66	passive	passive	ADJ
admet-275	3	67	)	)	PUNCT
admet-275	3	68	and	and	CCONJ
admet-275	3	69	by	by	ADP
admet-275	3	70	the	the	DET
admet-275	3	71	use	use	NOUN
admet-275	3	72	of	of	ADP
admet-275	3	73	specific	specific	ADJ
admet-275	3	74	organic	organic	ADJ
admet-275	3	75	cation	cation	NOUN
admet-275	3	76	transporter	transporter	NOUN
admet-275	3	77	(	(	PUNCT
admet-275	3	78	oct	oct	NOUN
admet-275	3	79	)	)	PUNCT
admet-275	3	80	inhibitors	inhibitor	NOUN
admet-275	3	81	.	.	PUNCT
admet-275	4	1	intracellular	intracellular	ADJ
admet-275	4	2	accumulation	accumulation	NOUN
admet-275	4	3	was	be	AUX
admet-275	4	4	determined	determine	VERB
admet-275	4	5	using	use	VERB
admet-275	4	6	caco-2	caco-2	NOUN
admet-275	4	7	as	as	ADP
admet-275	4	8	monolayers	monolayer	NOUN
admet-275	4	9	,	,	PUNCT
admet-275	4	10	while	while	SCONJ
admet-275	4	11	for	for	ADP
admet-275	4	12	gut	gut	NOUN
admet-275	4	13	permeation	permeation	NOUN
admet-275	4	14	we	we	PRON
admet-275	4	15	used	use	VERB
admet-275	4	16	differentiated	differentiate	VERB
admet-275	4	17	caco-2	caco-2	NOUN
admet-275	4	18	as	as	ADP
admet-275	4	19	model	model	NOUN
admet-275	4	20	for	for	ADP
admet-275	4	21	intestinal	intestinal	ADJ
admet-275	4	22	epithelium	epithelium	NOUN
admet-275	4	23	in	in	ADP
admet-275	4	24	the	the	DET
admet-275	4	25	transwell	transwell	NOUN
admet-275	4	26	system	system	NOUN
admet-275	4	27	.	.	PUNCT
admet-275	5	1	sorafenib	sorafenib	NOUN
admet-275	5	2	and	and	CCONJ
admet-275	5	3	crizotinib	crizotinib	VERB
admet-275	5	4	uptake	uptake	NOUN
admet-275	5	5	are	be	AUX
admet-275	5	6	likely	likely	ADJ
admet-275	5	7	to	to	PART
admet-275	5	8	be	be	AUX
admet-275	5	9	dependent	dependent	ADJ
admet-275	5	10	on	on	ADP
admet-275	5	11	passive	passive	ADJ
admet-275	5	12	transport	transport	NOUN
admet-275	5	13	.	.	PUNCT
admet-275	6	1	gefitinib	gefitinib	NOUN
admet-275	6	2	,	,	PUNCT
admet-275	6	3	dasatinib	dasatinib	NOUN
admet-275	6	4	and	and	CCONJ
admet-275	6	5	sunitinib	sunitinib	NOUN
admet-275	6	6	uptake	uptake	VERB
admet-275	6	7	seem	seem	VERB
admet-275	6	8	to	to	PART
admet-275	6	9	be	be	AUX
admet-275	6	10	active	active	ADJ
admet-275	6	11	.	.	PUNCT
admet-275	7	1	erlotinib	erlotinib	NOUN
admet-275	7	2	’s	’s	PART
admet-275	7	3	transport	transport	NOUN
admet-275	7	4	also	also	ADV
admet-275	7	5	seems	seem	VERB
admet-275	7	6	to	to	PART
admet-275	7	7	be	be	AUX
admet-275	7	8	active	active	ADJ
admet-275	7	9	.	.	PUNCT
admet-275	8	1	this	this	DET
admet-275	8	2	study	study	NOUN
admet-275	8	3	suggests	suggest	VERB
admet-275	8	4	that	that	SCONJ
admet-275	8	5	hocts	hoct	NOUN
admet-275	8	6	might	might	AUX
admet-275	8	7	be	be	AUX
admet-275	8	8	involved	involve	VERB
admet-275	8	9	in	in	ADP
admet-275	8	10	the	the	DET
admet-275	8	11	apical	apical	ADJ
admet-275	8	12	to	to	ADP
admet-275	8	13	basolateral	basolateral	ADJ
admet-275	8	14	transport	transport	NOUN
admet-275	8	15	of	of	ADP
admet-275	8	16	gefitinib	gefitinib	NOUN
admet-275	8	17	and	and	CCONJ
admet-275	8	18	crizotinib	crizotinib	NOUN
admet-275	8	19	.	.	PUNCT
admet-275	9	1	overall	overall	ADV
admet-275	9	2	it	it	PRON
admet-275	9	3	can	can	AUX
admet-275	9	4	be	be	AUX
admet-275	9	5	concluded	conclude	VERB
admet-275	9	6	that	that	SCONJ
admet-275	9	7	the	the	DET
admet-275	9	8	accumulation	accumulation	NOUN
admet-275	9	9	and	and	CCONJ
admet-275	9	10	transport	transport	NOUN
admet-275	9	11	of	of	ADP
admet-275	9	12	these	these	DET
admet-275	9	13	six	six	NUM
admet-275	9	14	tkis	tkis	NOUN
admet-275	9	15	are	be	AUX
admet-275	9	16	very	very	ADV
admet-275	9	17	different	different	ADJ
admet-275	9	18	,	,	PUNCT
admet-275	9	19	despite	despite	SCONJ
admet-275	9	20	the	the	DET
admet-275	9	21	fact	fact	NOUN
admet-275	9	22	that	that	SCONJ
admet-275	9	23	they	they	PRON
admet-275	9	24	are	be	AUX
admet-275	9	25	all	all	PRON
admet-275	9	26	tyrosine	tyrosine	NOUN
admet-275	9	27	kinase	kinase	NOUN
admet-275	9	28	inhibitors	inhibitor	NOUN
admet-275	9	29	.	.	PUNCT
admet-275	10	1	keywords	keyword	VERB
admet-275	10	2	tyrosine	tyrosine	PROPN
admet-275	10	3	kinase	kinase	PROPN
admet-275	10	4	;	;	PUNCT
admet-275	10	5	drug	drug	NOUN
admet-275	10	6	transport	transport	NOUN
admet-275	10	7	;	;	PUNCT
admet-275	10	8	erlorinib	erlorinib	NOUN
admet-275	10	9	;	;	PUNCT
admet-275	10	10	gefitinib	gefitinib	NOUN
admet-275	10	11	;	;	PUNCT
admet-275	10	12	sorafenib	sorafenib	NOUN
admet-275	10	13	;	;	PUNCT
admet-275	10	14	sunitinib	sunitinib	NOUN
admet-275	10	15	;	;	PUNCT
admet-275	10	16	dasatinib	dasatinib	NOUN
admet-275	10	17	;	;	PUNCT
admet-275	10	18	crizotinib	crizotinib	VERB
admet-275	10	19	introduction	introduction	NOUN
admet-275	10	20	protein	protein	NOUN
admet-275	10	21	kinases	kinase	NOUN
admet-275	10	22	are	be	AUX
admet-275	10	23	key	key	ADJ
admet-275	10	24	regulator	regulator	NOUN
admet-275	10	25	enzymes	enzyme	NOUN
admet-275	10	26	of	of	ADP
admet-275	10	27	cell	cell	NOUN
admet-275	10	28	function	function	NOUN
admet-275	10	29	via	via	ADP
admet-275	10	30	the	the	DET
admet-275	10	31	transfer	transfer	NOUN
admet-275	10	32	of	of	ADP
admet-275	10	33	a	a	DET
admet-275	10	34	phosphate	phosphate	ADJ
admet-275	10	35	group	group	NOUN
admet-275	10	36	from	from	ADP
admet-275	10	37	atp	atp	PROPN
admet-275	10	38	to	to	ADP
admet-275	10	39	a	a	DET
admet-275	10	40	protein	protein	NOUN
admet-275	10	41	in	in	ADP
admet-275	10	42	a	a	DET
admet-275	10	43	cell	cell	NOUN
admet-275	10	44	[	[	X
admet-275	10	45	1	1	NUM
admet-275	10	46	]	]	PUNCT
admet-275	10	47	.	.	PUNCT
admet-275	11	1	one	one	NUM
admet-275	11	2	of	of	ADP
admet-275	11	3	the	the	DET
admet-275	11	4	subgroups	subgroup	NOUN
admet-275	11	5	is	be	AUX
admet-275	11	6	the	the	DET
admet-275	11	7	tyrosine	tyrosine	NOUN
admet-275	11	8	kinases	kinase	NOUN
admet-275	11	9	(	(	PUNCT
admet-275	11	10	tk	tk	PROPN
admet-275	11	11	)	)	PUNCT
admet-275	11	12	family	family	NOUN
admet-275	11	13	.	.	PUNCT
admet-275	12	1	these	these	DET
admet-275	12	2	kinases	kinase	NOUN
admet-275	12	3	attach	attach	VERB
admet-275	12	4	phosphate	phosphate	ADJ
admet-275	12	5	groups	group	NOUN
admet-275	12	6	to	to	ADP
admet-275	12	7	the	the	DET
admet-275	12	8	amino	amino	NOUN
admet-275	12	9	acid	acid	NOUN
admet-275	12	10	tyrosine	tyrosine	NOUN
admet-275	12	11	of	of	ADP
admet-275	12	12	a	a	DET
admet-275	12	13	protein	protein	NOUN
admet-275	12	14	,	,	PUNCT
admet-275	12	15	controlling	control	VERB
admet-275	12	16	a	a	DET
admet-275	12	17	wide	wide	ADJ
admet-275	12	18	range	range	NOUN
admet-275	12	19	of	of	ADP
admet-275	12	20	properties	property	NOUN
admet-275	12	21	in	in	ADP
admet-275	12	22	proteins	protein	NOUN
admet-275	12	23	such	such	ADJ
admet-275	12	24	as	as	ADP
admet-275	12	25	,	,	PUNCT
admet-275	12	26	but	but	CCONJ
admet-275	12	27	not	not	PART
admet-275	12	28	limited	limit	VERB
admet-275	12	29	to	to	ADP
admet-275	12	30	,	,	PUNCT
admet-275	12	31	differentiation	differentiation	NOUN
admet-275	12	32	,	,	PUNCT
admet-275	12	33	apoptosis	apoptosis	NOUN
admet-275	12	34	,	,	PUNCT
admet-275	12	35	enzyme	enzyme	NOUN
admet-275	12	36	activity	activity	NOUN
admet-275	12	37	,	,	PUNCT
admet-275	12	38	subcellular	subcellular	ADJ
admet-275	12	39	localization	localization	NOUN
admet-275	12	40	and	and	CCONJ
admet-275	12	41	interaction	interaction	NOUN
admet-275	12	42	between	between	ADP
admet-275	12	43	molecules	molecule	NOUN
admet-275	12	44	[	[	X
admet-275	12	45	2	2	NUM
admet-275	12	46	]	]	PUNCT
admet-275	12	47	.	.	PUNCT
admet-275	13	1	subsequently	subsequently	ADV
admet-275	13	2	,	,	PUNCT
admet-275	13	3	tks	tks	NOUN
admet-275	13	4	function	function	NOUN
admet-275	13	5	in	in	ADP
admet-275	13	6	many	many	ADJ
admet-275	13	7	signaling	signal	VERB
admet-275	13	8	transduction	transduction	NOUN
admet-275	13	9	cascades	cascade	NOUN
admet-275	13	10	,	,	PUNCT
admet-275	13	11	controlling	control	VERB
admet-275	13	12	fundamental	fundamental	ADJ
admet-275	13	13	cellular	cellular	ADJ
admet-275	13	14	processes	process	NOUN
admet-275	13	15	including	include	VERB
admet-275	13	16	cell	cell	NOUN
admet-275	13	17	cycle	cycle	NOUN
admet-275	13	18	,	,	PUNCT
admet-275	13	19	migration	migration	NOUN
admet-275	13	20	,	,	PUNCT
admet-275	13	21	survival	survival	NOUN
admet-275	13	22	,	,	PUNCT
admet-275	13	23	proliferation	proliferation	NOUN
admet-275	13	24	and	and	CCONJ
admet-275	13	25	metabolism	metabolism	NOUN
admet-275	14	1	[	[	X
admet-275	14	2	3	3	NUM
admet-275	14	3	]	]	PUNCT
admet-275	14	4	.	.	PUNCT
admet-275	15	1	receptor	receptor	NOUN
admet-275	15	2	tks	tks	NOUN
admet-275	15	3	consist	consist	NOUN
admet-275	15	4	of	of	ADP
admet-275	15	5	an	an	DET
admet-275	15	6	extracellular	extracellular	ADJ
admet-275	15	7	ligand	ligand	NOUN
admet-275	15	8	binding	bind	VERB
admet-275	15	9	domain	domain	NOUN
admet-275	15	10	which	which	PRON
admet-275	15	11	is	be	AUX
admet-275	15	12	connected	connect	VERB
admet-275	15	13	to	to	ADP
admet-275	15	14	the	the	DET
admet-275	15	15	cytoplasmic	cytoplasmic	ADJ
admet-275	15	16	domain	domain	NOUN
admet-275	15	17	by	by	ADP
admet-275	15	18	a	a	DET
admet-275	15	19	single	single	ADJ
admet-275	15	20	trans	trans	ADJ
admet-275	15	21	-	-	ADJ
admet-275	15	22	membrane	membrane	ADJ
admet-275	15	23	helix	helix	NOUN
admet-275	15	24	.	.	PUNCT
admet-275	16	1	the	the	DET
admet-275	16	2	binding	binding	NOUN
admet-275	16	3	of	of	ADP
admet-275	16	4	a	a	DET
admet-275	16	5	ligand	ligand	NOUN
admet-275	16	6	to	to	ADP
admet-275	16	7	the	the	DET
admet-275	16	8	receptor	receptor	NOUN
admet-275	16	9	induces	induce	VERB
admet-275	16	10	dimerization	dimerization	NOUN
admet-275	16	11	resulting	result	VERB
admet-275	16	12	in	in	ADP
admet-275	16	13	internal	internal	ADJ
admet-275	16	14	activation	activation	NOUN
admet-275	16	15	of	of	ADP
admet-275	16	16	the	the	DET
admet-275	16	17	rtk	rtk	PROPN
admet-275	16	18	[	[	X
admet-275	16	19	4,5	4,5	NUM
admet-275	16	20	]	]	PUNCT
admet-275	16	21	.	.	PUNCT
admet-275	17	1	mutations	mutation	NOUN
admet-275	17	2	in	in	ADP
admet-275	17	3	the	the	DET
admet-275	17	4	atp	atp	NOUN
admet-275	17	5	-	-	PUNCT
admet-275	17	6	binding	bind	VERB
admet-275	17	7	site	site	NOUN
admet-275	17	8	can	can	AUX
admet-275	17	9	cause	cause	VERB
admet-275	17	10	some	some	DET
admet-275	17	11	tks	tks	NOUN
admet-275	17	12	to	to	PART
admet-275	17	13	become	become	VERB
admet-275	17	14	constitutively	constitutively	ADV
admet-275	17	15	active	active	ADJ
admet-275	17	16	which	which	PRON
admet-275	17	17	results	result	VERB
admet-275	17	18	in	in	ADP
admet-275	17	19	a	a	DET
admet-275	17	20	non	non	ADJ
admet-275	17	21	-	-	ADJ
admet-275	17	22	stop	stop	ADJ
admet-275	17	23	functional	functional	ADJ
admet-275	17	24	state	state	NOUN
admet-275	17	25	that	that	PRON
admet-275	17	26	may	may	AUX
admet-275	17	27	contribute	contribute	VERB
admet-275	17	28	to	to	ADP
admet-275	17	29	initiation	initiation	NOUN
admet-275	17	30	or	or	CCONJ
admet-275	17	31	progression	progression	NOUN
admet-275	17	32	of	of	ADP
admet-275	17	33	cancer	cancer	NOUN
admet-275	17	34	[	[	X
admet-275	17	35	6	6	NUM
admet-275	17	36	]	]	PUNCT
admet-275	17	37	.	.	PUNCT
admet-275	18	1	small	small	ADJ
admet-275	18	2	molecule	molecule	NOUN
admet-275	18	3	tyrosine	tyrosine	NOUN
admet-275	18	4	kinase	kinase	PROPN
admet-275	18	5	inhibitors	inhibitor	NOUN
admet-275	18	6	(	(	PUNCT
admet-275	18	7	tkis	tkis	NOUN
admet-275	18	8	)	)	PUNCT
admet-275	18	9	were	be	AUX
admet-275	18	10	developed	develop	VERB
admet-275	18	11	to	to	PART
admet-275	18	12	inhibit	inhibit	VERB
admet-275	18	13	tk	tk	PROPN
admet-275	18	14	function	function	NOUN
admet-275	18	15	.	.	PUNCT
admet-275	19	1	in	in	ADP
admet-275	19	2	this	this	DET
admet-275	19	3	study	study	NOUN
admet-275	19	4	,	,	PUNCT
admet-275	19	5	six	six	NUM
admet-275	19	6	different	different	ADJ
admet-275	19	7	tkis	tki	NOUN
admet-275	19	8	were	be	AUX
admet-275	19	9	investigated	investigate	VERB
admet-275	19	10	.	.	PUNCT
admet-275	20	1	erlotinib	erlotinib	NOUN
admet-275	20	2	and	and	CCONJ
admet-275	20	3	gefitinib	gefitinib	NOUN
admet-275	20	4	are	be	AUX
admet-275	20	5	reversible	reversible	ADJ
admet-275	20	6	inhibitors	inhibitor	NOUN
admet-275	20	7	of	of	ADP
admet-275	20	8	the	the	DET
admet-275	20	9	epidermal	epidermal	ADJ
admet-275	20	10	growth	growth	NOUN
admet-275	20	11	factor	factor	NOUN
admet-275	20	12	receptor	receptor	NOUN
admet-275	20	13	tyrosine	tyrosine	PROPN
admet-275	20	14	kinase	kinase	PROPN
admet-275	20	15	(	(	PUNCT
admet-275	20	16	egfr	egfr	X
admet-275	20	17	)	)	PUNCT
admet-275	21	1	[	[	X
admet-275	21	2	7	7	X
admet-275	21	3	]	]	PUNCT
admet-275	21	4	and	and	CCONJ
admet-275	21	5	are	be	AUX
admet-275	21	6	approved	approve	VERB
admet-275	21	7	for	for	ADP
admet-275	21	8	treatment	treatment	NOUN
admet-275	21	9	of	of	ADP
admet-275	21	10	non	non	ADJ
admet-275	21	11	-	-	ADJ
admet-275	21	12	small	small	ADJ
admet-275	21	13	-	-	PUNCT
admet-275	21	14	cell	cell	NOUN
admet-275	21	15	lung	lung	NOUN
admet-275	21	16	cancer	cancer	NOUN
admet-275	21	17	(	(	PUNCT
admet-275	21	18	nsclc	nsclc	NOUN
admet-275	21	19	)	)	PUNCT
admet-275	22	1	[	[	X
admet-275	22	2	8	8	NUM
admet-275	22	3	-	-	SYM
admet-275	22	4	10	10	NUM
admet-275	22	5	]	]	PUNCT
admet-275	22	6	.	.	PUNCT
admet-275	23	1	sorafenib	sorafenib	PROPN
admet-275	23	2	is	be	AUX
admet-275	23	3	a	a	DET
admet-275	23	4	multiple	multiple	ADJ
admet-275	23	5	kinase	kinase	NOUN
admet-275	23	6	inhibitor	inhibitor	NOUN
admet-275	23	7	which	which	PRON
admet-275	23	8	inhibits	inhibit	VERB
admet-275	23	9	multiple	multiple	ADJ
admet-275	23	10	intracellular	intracellular	ADJ
admet-275	23	11	(	(	PUNCT
admet-275	23	12	craf	craf	NOUN
admet-275	23	13	,	,	PUNCT
admet-275	23	14	(	(	PUNCT
admet-275	23	15	mutant	mutant	ADJ
admet-275	23	16	)	)	PUNCT
admet-275	23	17	braf	braf	NOUN
admet-275	23	18	)	)	PUNCT
admet-275	23	19	and	and	CCONJ
admet-275	23	20	receptor	receptor	NOUN
admet-275	23	21	cell	cell	NOUN
admet-275	23	22	surface	surface	NOUN
admet-275	23	23	kinases	kinase	NOUN
admet-275	23	24	(	(	PUNCT
admet-275	23	25	kit	kit	NOUN
admet-275	23	26	,	,	PUNCT
admet-275	23	27	flt-3	flt-3	NOUN
admet-275	23	28	,	,	PUNCT
admet-275	23	29	ret	ret	PROPN
admet-275	23	30	,	,	PUNCT
admet-275	23	31	vegfr-1/2/3	vegfr-1/2/3	PROPN
admet-275	23	32	,	,	PUNCT
admet-275	23	33	and	and	CCONJ
admet-275	23	34	pdgfr	pdgfr	ADJ
admet-275	23	35	-	-	PUNCT
admet-275	23	36	β	β	NOUN
admet-275	23	37	)	)	PUNCT
admet-275	24	1	[	[	X
admet-275	24	2	11	11	NUM
admet-275	24	3	]	]	PUNCT
admet-275	24	4	.	.	PUNCT
admet-275	25	1	sorafenib	sorafenib	PROPN
admet-275	25	2	is	be	AUX
admet-275	25	3	approved	approve	VERB
admet-275	25	4	for	for	ADP
admet-275	25	5	liver	liver	NOUN
admet-275	25	6	(	(	PUNCT
admet-275	25	7	hepatocellular	hepatocellular	ADJ
admet-275	25	8	carcinoma	carcinoma	NOUN
admet-275	25	9	(	(	PUNCT
admet-275	25	10	hcc	hcc	PROPN
admet-275	25	11	)	)	PUNCT
admet-275	25	12	)	)	PUNCT
admet-275	25	13	and	and	CCONJ
admet-275	25	14	kidney	kidney	NOUN
admet-275	25	15	(	(	PUNCT
admet-275	25	16	renal	renal	ADJ
admet-275	25	17	cell	cell	NOUN
admet-275	25	18	carcinoma	carcinoma	NOUN
admet-275	25	19	(	(	PUNCT
admet-275	25	20	rcc	rcc	PROPN
admet-275	25	21	)	)	PUNCT
admet-275	25	22	)	)	PUNCT
admet-275	25	23	cancer	cancer	NOUN
admet-275	25	24	[	[	X
admet-275	25	25	12,13	12,13	NUM
admet-275	25	26	]	]	PUNCT
admet-275	25	27	.	.	PUNCT
admet-275	26	1	sunitinib	sunitinib	NOUN
admet-275	26	2	is	be	AUX
admet-275	26	3	also	also	ADV
admet-275	26	4	a	a	DET
admet-275	26	5	multi	multi	ADJ
admet-275	26	6	-	-	ADJ
admet-275	26	7	targeted	target	VERB
admet-275	26	8	receptor	receptor	NOUN
admet-275	26	9	tki	tki	NOUN
admet-275	26	10	which	which	PRON
admet-275	26	11	is	be	AUX
admet-275	26	12	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-275	26	13	honeywell	honeywell	PROPN
admet-275	26	14	et	et	PROPN
admet-275	26	15	al	al	PROPN
admet-275	26	16	.	.	PROPN
admet-275	26	17	admet	admet	PROPN
admet-275	26	18	&	&	CCONJ
admet-275	26	19	dmpk	dmpk	PROPN
admet-275	26	20	4(1	4(1	NOUN
admet-275	26	21	)	)	PUNCT
admet-275	26	22	(	(	PUNCT
admet-275	26	23	2016	2016	NUM
admet-275	26	24	)	)	PUNCT
admet-275	26	25	23	23	NUM
admet-275	26	26	-	-	SYM
admet-275	26	27	34	34	NUM
admet-275	26	28	24	24	NUM
admet-275	26	29	known	know	VERB
admet-275	26	30	to	to	PART
admet-275	26	31	inhibit	inhibit	VERB
admet-275	26	32	vegfr	vegfr	NOUN
admet-275	26	33	,	,	PUNCT
admet-275	26	34	pdgfr	pdgfr	ADJ
admet-275	26	35	,	,	PUNCT
admet-275	26	36	kit	kit	NOUN
admet-275	26	37	,	,	PUNCT
admet-275	26	38	ret	ret	PROPN
admet-275	26	39	,	,	PUNCT
admet-275	26	40	csf-1	csf-1	PUNCT
admet-275	26	41	and	and	CCONJ
admet-275	26	42	flt3	flt3	PROPN
admet-275	27	1	[	[	X
admet-275	27	2	14	14	NUM
admet-275	27	3	]	]	PUNCT
admet-275	27	4	.	.	PUNCT
admet-275	28	1	sunitinib	sunitinib	PROPN
admet-275	28	2	is	be	AUX
admet-275	28	3	fda	fda	PROPN
admet-275	28	4	approved	approve	VERB
admet-275	28	5	for	for	ADP
admet-275	28	6	multiple	multiple	ADJ
admet-275	28	7	cancer	cancer	NOUN
admet-275	28	8	types	type	NOUN
admet-275	28	9	,	,	PUNCT
admet-275	28	10	namely	namely	ADV
admet-275	28	11	gastrointestinal	gastrointestinal	ADJ
admet-275	28	12	stromal	stromal	ADJ
admet-275	28	13	tumor	tumor	NOUN
admet-275	28	14	(	(	PUNCT
admet-275	28	15	gist	gist	NOUN
admet-275	28	16	)	)	PUNCT
admet-275	28	17	,	,	PUNCT
admet-275	28	18	kidney	kidney	NOUN
admet-275	28	19	cancer	cancer	NOUN
admet-275	28	20	(	(	PUNCT
admet-275	28	21	rcc	rcc	PROPN
admet-275	28	22	)	)	PUNCT
admet-275	28	23	and	and	CCONJ
admet-275	28	24	pancreatic	pancreatic	ADJ
admet-275	28	25	neuroendocrine	neuroendocrine	NOUN
admet-275	28	26	tumors	tumor	NOUN
admet-275	28	27	(	(	PUNCT
admet-275	28	28	pnet	pnet	PROPN
admet-275	28	29	)	)	PUNCT
admet-275	29	1	[	[	X
admet-275	29	2	15	15	NUM
admet-275	29	3	-	-	SYM
admet-275	29	4	17	17	NUM
admet-275	29	5	]	]	PUNCT
admet-275	29	6	.	.	PUNCT
admet-275	30	1	dasatinib	dasatinib	NOUN
admet-275	30	2	is	be	AUX
admet-275	30	3	a	a	DET
admet-275	30	4	bcr	bcr	ADJ
admet-275	30	5	-	-	ADJ
admet-275	30	6	abl	abl	NOUN
admet-275	30	7	inhibitor	inhibitor	NOUN
admet-275	30	8	,	,	PUNCT
admet-275	30	9	but	but	CCONJ
admet-275	30	10	can	can	AUX
admet-275	30	11	also	also	ADV
admet-275	30	12	inhibit	inhibit	VERB
admet-275	30	13	pdgfr	pdgfr	ADJ
admet-275	30	14	,	,	PUNCT
admet-275	30	15	c	c	NOUN
admet-275	30	16	-	-	PUNCT
admet-275	30	17	kit	kit	NOUN
admet-275	30	18	,	,	PUNCT
admet-275	30	19	src	src	NOUN
admet-275	30	20	and	and	CCONJ
admet-275	30	21	the	the	DET
admet-275	30	22	ephrin	ephrin	NOUN
admet-275	30	23	a	a	DET
admet-275	30	24	receptor	receptor	NOUN
admet-275	30	25	[	[	X
admet-275	30	26	18	18	NUM
admet-275	30	27	]	]	PUNCT
admet-275	30	28	.	.	PUNCT
admet-275	31	1	dasatinib	dasatinib	NOUN
admet-275	31	2	was	be	AUX
admet-275	31	3	fda	fda	PROPN
admet-275	31	4	approved	approve	VERB
admet-275	31	5	for	for	ADP
admet-275	31	6	the	the	DET
admet-275	31	7	treatment	treatment	NOUN
admet-275	31	8	of	of	ADP
admet-275	31	9	chronic	chronic	ADJ
admet-275	31	10	myeloid	myeloid	NOUN
admet-275	31	11	leukemia	leukemia	NOUN
admet-275	31	12	(	(	PUNCT
admet-275	31	13	cml	cml	PROPN
admet-275	31	14	)	)	PUNCT
admet-275	32	1	[	[	X
admet-275	32	2	19	19	NUM
admet-275	32	3	]	]	PUNCT
admet-275	32	4	.	.	PUNCT
admet-275	33	1	crizotinib	crizotinib	PROPN
admet-275	33	2	is	be	AUX
admet-275	33	3	a	a	DET
admet-275	33	4	met	meet	VERB
admet-275	33	5	/	/	SYM
admet-275	33	6	alk	alk	VERB
admet-275	33	7	multi	multi	ADJ
admet-275	33	8	-	-	ADJ
admet-275	33	9	targeted	targeted	ADJ
admet-275	33	10	(	(	PUNCT
admet-275	33	11	alk	alk	PROPN
admet-275	33	12	,	,	PUNCT
admet-275	33	13	ros1	ros1	PROPN
admet-275	33	14	,	,	PUNCT
admet-275	33	15	cmet	cmet	NOUN
admet-275	33	16	)	)	PUNCT
admet-275	33	17	receptor	receptor	NOUN
admet-275	33	18	tki	tki	NOUN
admet-275	33	19	approved	approve	VERB
admet-275	33	20	for	for	ADP
admet-275	33	21	nsclc	nsclc	NOUN
admet-275	33	22	[	[	X
admet-275	33	23	20,21	20,21	NUM
admet-275	33	24	]	]	PUNCT
admet-275	33	25	.	.	PUNCT
admet-275	34	1	generally	generally	ADV
admet-275	34	2	,	,	PUNCT
admet-275	34	3	tkis	tkis	PROPN
admet-275	34	4	are	be	AUX
admet-275	34	5	poorly	poorly	ADV
admet-275	34	6	soluble	soluble	ADJ
admet-275	34	7	in	in	ADP
admet-275	34	8	aqueous	aqueous	ADJ
admet-275	34	9	solutions	solution	NOUN
admet-275	34	10	,	,	PUNCT
admet-275	34	11	leading	lead	VERB
admet-275	34	12	to	to	ADP
admet-275	34	13	poor	poor	ADJ
admet-275	34	14	bioavailability	bioavailability	NOUN
admet-275	34	15	[	[	X
admet-275	34	16	22,23	22,23	NOUN
admet-275	34	17	]	]	PUNCT
admet-275	34	18	.	.	PUNCT
admet-275	35	1	this	this	PRON
admet-275	35	2	may	may	AUX
admet-275	35	3	also	also	ADV
admet-275	35	4	affect	affect	VERB
admet-275	35	5	uptake	uptake	ADJ
admet-275	35	6	and	and	CCONJ
admet-275	35	7	efflux	efflux	VERB
admet-275	35	8	of	of	ADP
admet-275	35	9	these	these	DET
admet-275	35	10	compounds	compound	NOUN
admet-275	35	11	.	.	PUNCT
admet-275	36	1	efflux	efflux	NOUN
admet-275	36	2	is	be	AUX
admet-275	36	3	mediated	mediate	VERB
admet-275	36	4	by	by	ADP
admet-275	36	5	atp	atp	PROPN
admet-275	36	6	-	-	PUNCT
admet-275	36	7	dependent	dependent	ADJ
admet-275	36	8	efflux	efflux	NOUN
admet-275	36	9	pumps	pump	NOUN
admet-275	36	10	of	of	ADP
admet-275	36	11	the	the	DET
admet-275	36	12	atp	atp	NOUN
admet-275	36	13	-	-	PUNCT
admet-275	36	14	binding	bind	VERB
admet-275	36	15	cassette	cassette	NOUN
admet-275	36	16	(	(	PUNCT
admet-275	36	17	abc	abc	PROPN
admet-275	36	18	)	)	PUNCT
admet-275	36	19	family	family	NOUN
admet-275	36	20	,	,	PUNCT
admet-275	36	21	such	such	ADJ
admet-275	36	22	as	as	ADP
admet-275	36	23	bcrp	bcrp	PROPN
admet-275	36	24	(	(	PUNCT
admet-275	36	25	abcg2	abcg2	NOUN
admet-275	36	26	)	)	PUNCT
admet-275	36	27	,	,	PUNCT
admet-275	36	28	p	p	NOUN
admet-275	36	29	-	-	PUNCT
admet-275	36	30	gp	gp	NOUN
admet-275	36	31	(	(	PUNCT
admet-275	36	32	abcb1	abcb1	NOUN
admet-275	36	33	)	)	PUNCT
admet-275	36	34	and	and	CCONJ
admet-275	36	35	multidrug	multidrug	VERB
admet-275	36	36	resistance	resistance	NOUN
admet-275	36	37	protein	protein	NOUN
admet-275	36	38	1	1	NUM
admet-275	36	39	(	(	PUNCT
admet-275	36	40	mrp1	mrp1	NOUN
admet-275	36	41	)	)	PUNCT
admet-275	37	1	[	[	X
admet-275	37	2	24	24	NUM
admet-275	37	3	-	-	SYM
admet-275	37	4	26	26	NUM
admet-275	37	5	]	]	PUNCT
admet-275	37	6	.	.	PUNCT
admet-275	38	1	influx	influx	PROPN
admet-275	38	2	pumps	pump	NOUN
admet-275	38	3	include	include	VERB
admet-275	38	4	the	the	DET
admet-275	38	5	organic	organic	ADJ
admet-275	38	6	cation	cation	NOUN
admet-275	38	7	transporters	transporter	NOUN
admet-275	38	8	(	(	PUNCT
admet-275	38	9	octs	oct	NOUN
admet-275	38	10	)	)	PUNCT
admet-275	38	11	.	.	PUNCT
admet-275	39	1	since	since	SCONJ
admet-275	39	2	several	several	ADJ
admet-275	39	3	tkis	tkis	NOUN
admet-275	39	4	have	have	VERB
admet-275	39	5	a	a	DET
admet-275	39	6	cationic	cationic	ADJ
admet-275	39	7	charge	charge	NOUN
admet-275	39	8	and	and	CCONJ
admet-275	39	9	high	high	ADJ
admet-275	39	10	lipophilicity	lipophilicity	NOUN
admet-275	39	11	,	,	PUNCT
admet-275	39	12	they	they	PRON
admet-275	39	13	are	be	AUX
admet-275	39	14	substrates	substrate	NOUN
admet-275	39	15	for	for	ADP
admet-275	39	16	octs	oct	NOUN
admet-275	39	17	[	[	X
admet-275	39	18	22,27,28	22,27,28	NUM
admet-275	39	19	]	]	X
admet-275	39	20	.	.	PUNCT
admet-275	40	1	tkis	tkis	PROPN
admet-275	40	2	are	be	AUX
admet-275	40	3	oral	oral	ADJ
admet-275	40	4	drugs	drug	NOUN
admet-275	40	5	that	that	PRON
admet-275	40	6	have	have	VERB
admet-275	40	7	to	to	PART
admet-275	40	8	pass	pass	VERB
admet-275	40	9	the	the	DET
admet-275	40	10	intestine	intestine	NOUN
admet-275	40	11	barrier	barrier	NOUN
admet-275	40	12	to	to	PART
admet-275	40	13	enter	enter	VERB
admet-275	40	14	the	the	DET
admet-275	40	15	systemic	systemic	ADJ
admet-275	40	16	circulation	circulation	NOUN
admet-275	40	17	.	.	PUNCT
admet-275	41	1	therefore	therefore	ADV
admet-275	41	2	,	,	PUNCT
admet-275	41	3	transport	transport	NOUN
admet-275	41	4	proteins	protein	NOUN
admet-275	41	5	on	on	ADP
admet-275	41	6	the	the	DET
admet-275	41	7	intestinal	intestinal	ADJ
admet-275	41	8	epithelia	epithelium	NOUN
admet-275	41	9	are	be	AUX
admet-275	41	10	very	very	ADV
admet-275	41	11	important	important	ADJ
admet-275	41	12	in	in	ADP
admet-275	41	13	the	the	DET
admet-275	41	14	drug	drug	NOUN
admet-275	41	15	bioavailability	bioavailability	NOUN
admet-275	41	16	and	and	CCONJ
admet-275	41	17	resistance	resistance	NOUN
admet-275	41	18	mechanisms	mechanism	NOUN
admet-275	41	19	[	[	X
admet-275	41	20	22,29	22,29	NOUN
admet-275	41	21	]	]	PUNCT
admet-275	41	22	.	.	PUNCT
admet-275	42	1	the	the	DET
admet-275	42	2	human	human	ADJ
admet-275	42	3	colon	colon	NOUN
admet-275	42	4	carcinoma	carcinoma	NOUN
admet-275	42	5	cell	cell	NOUN
admet-275	42	6	line	line	NOUN
admet-275	42	7	caco-2	caco-2	NUM
admet-275	42	8	mimics	mimic	VERB
admet-275	42	9	the	the	DET
admet-275	42	10	epithelial	epithelial	ADJ
admet-275	42	11	monolayer	monolayer	NOUN
admet-275	42	12	,	,	PUNCT
admet-275	42	13	which	which	PRON
admet-275	42	14	covers	cover	VERB
admet-275	42	15	the	the	DET
admet-275	42	16	inner	inner	ADJ
admet-275	42	17	intestinal	intestinal	ADJ
admet-275	42	18	wall	wall	NOUN
admet-275	42	19	and	and	CCONJ
admet-275	42	20	has	have	AUX
admet-275	42	21	been	be	AUX
admet-275	42	22	used	use	VERB
admet-275	42	23	as	as	ADP
admet-275	42	24	a	a	DET
admet-275	42	25	model	model	NOUN
admet-275	42	26	system	system	NOUN
admet-275	42	27	for	for	ADP
admet-275	42	28	drug	drug	NOUN
admet-275	42	29	investigation	investigation	NOUN
admet-275	42	30	[	[	X
admet-275	42	31	30	30	NUM
admet-275	42	32	]	]	PUNCT
admet-275	42	33	(	(	PUNCT
admet-275	42	34	figure	figure	NOUN
admet-275	42	35	1	1	NUM
admet-275	42	36	)	)	PUNCT
admet-275	42	37	.	.	PUNCT
admet-275	43	1	the	the	DET
admet-275	43	2	hoct1	hoct1	NOUN
admet-275	43	3	(	(	PUNCT
admet-275	43	4	basolateral	basolateral	NOUN
admet-275	43	5	)	)	PUNCT
admet-275	43	6	and	and	CCONJ
admet-275	43	7	hoct3	hoct3	NOUN
admet-275	43	8	(	(	PUNCT
admet-275	43	9	apical	apical	ADJ
admet-275	43	10	)	)	PUNCT
admet-275	43	11	are	be	AUX
admet-275	43	12	known	know	VERB
admet-275	43	13	to	to	PART
admet-275	43	14	be	be	AUX
admet-275	43	15	functional	functional	ADJ
admet-275	43	16	present	present	ADJ
admet-275	43	17	at	at	ADP
admet-275	43	18	the	the	DET
admet-275	43	19	intestinal	intestinal	ADJ
admet-275	43	20	level	level	NOUN
admet-275	43	21	(	(	PUNCT
admet-275	43	22	caco2	caco2	NOUN
admet-275	43	23	cells	cell	NOUN
admet-275	43	24	)	)	PUNCT
admet-275	44	1	[	[	X
admet-275	44	2	31,32	31,32	NUM
admet-275	44	3	]	]	PUNCT
admet-275	44	4	.	.	PUNCT
admet-275	45	1	we	we	PRON
admet-275	45	2	recently	recently	ADV
admet-275	45	3	validated	validate	VERB
admet-275	45	4	the	the	DET
admet-275	45	5	caco-2	caco-2	NUM
admet-275	45	6	permeable	permeable	ADJ
admet-275	45	7	cell	cell	NOUN
admet-275	45	8	culture	culture	NOUN
admet-275	45	9	system	system	NOUN
admet-275	45	10	for	for	ADP
admet-275	45	11	permeation	permeation	NOUN
admet-275	45	12	of	of	ADP
admet-275	45	13	several	several	ADJ
admet-275	45	14	tkis	tkis	NOUN
admet-275	46	1	[	[	X
admet-275	46	2	33	33	NUM
admet-275	46	3	]	]	PUNCT
admet-275	47	1	and	and	CCONJ
admet-275	47	2	applied	apply	VERB
admet-275	47	3	it	it	PRON
admet-275	47	4	to	to	PART
admet-275	47	5	determine	determine	VERB
admet-275	47	6	the	the	DET
admet-275	47	7	role	role	NOUN
admet-275	47	8	of	of	ADP
admet-275	47	9	various	various	ADJ
admet-275	47	10	drug	drug	NOUN
admet-275	47	11	transporters	transporter	NOUN
admet-275	47	12	in	in	ADP
admet-275	47	13	permeability	permeability	NOUN
admet-275	47	14	and	and	CCONJ
admet-275	47	15	absorption	absorption	NOUN
admet-275	47	16	of	of	ADP
admet-275	47	17	erlotinib	erlotinib	PROPN
admet-275	47	18	,	,	PUNCT
admet-275	47	19	gefitinib	gefitinib	NOUN
admet-275	47	20	,	,	PUNCT
admet-275	47	21	sorafenib	sorafenib	NOUN
admet-275	47	22	,	,	PUNCT
admet-275	47	23	sunitinib	sunitinib	NOUN
admet-275	47	24	,	,	PUNCT
admet-275	47	25	dasatinib	dasatinib	NOUN
admet-275	47	26	and	and	CCONJ
admet-275	47	27	crizotinib	crizotinib	VERB
admet-275	47	28	,	,	PUNCT
admet-275	47	29	by	by	ADP
admet-275	47	30	using	use	VERB
admet-275	47	31	several	several	ADJ
admet-275	47	32	specific	specific	ADJ
admet-275	47	33	inhibitors	inhibitor	NOUN
admet-275	47	34	of	of	ADP
admet-275	47	35	these	these	DET
admet-275	47	36	pumps	pump	NOUN
admet-275	47	37	.	.	PUNCT
admet-275	48	1	materials	material	NOUN
admet-275	48	2	and	and	CCONJ
admet-275	48	3	methods	method	NOUN
admet-275	48	4	materials	material	NOUN
admet-275	48	5	erlotinib	erlotinib	NOUN
admet-275	48	6	,	,	PUNCT
admet-275	48	7	gefitinib	gefitinib	NOUN
admet-275	48	8	,	,	PUNCT
admet-275	48	9	sorafenib	sorafenib	NOUN
admet-275	48	10	,	,	PUNCT
admet-275	48	11	sunitinib	sunitinib	NOUN
admet-275	48	12	,	,	PUNCT
admet-275	48	13	dasatinib	dasatinib	NOUN
admet-275	48	14	,	,	PUNCT
admet-275	48	15	crizotinib	crizotinib	NOUN
admet-275	48	16	were	be	AUX
admet-275	48	17	from	from	ADP
admet-275	48	18	lc	lc	PROPN
admet-275	48	19	laboratories	laboratory	NOUN
admet-275	48	20	(	(	PUNCT
admet-275	48	21	woburn	woburn	PROPN
admet-275	48	22	,	,	PUNCT
admet-275	48	23	usa	usa	PROPN
admet-275	48	24	)	)	PUNCT
admet-275	48	25	.	.	PUNCT
admet-275	49	1	amantadine	amantadine	NOUN
admet-275	49	2	,	,	PUNCT
admet-275	49	3	β	β	NOUN
admet-275	49	4	-	-	PUNCT
admet-275	49	5	estradiol	estradiol	PROPN
admet-275	49	6	,	,	PUNCT
admet-275	49	7	cimetidine	cimetidine	NOUN
admet-275	49	8	and	and	CCONJ
admet-275	49	9	verapamil	verapamil	NOUN
admet-275	49	10	were	be	AUX
admet-275	49	11	purchased	purchase	VERB
admet-275	49	12	from	from	ADP
admet-275	49	13	sigma	sigma	PROPN
admet-275	49	14	(	(	PUNCT
admet-275	49	15	st	st	PROPN
admet-275	49	16	.	.	PROPN
admet-275	49	17	louis	louis	PROPN
admet-275	49	18	,	,	PUNCT
admet-275	49	19	mo	mo	PROPN
admet-275	49	20	,	,	PUNCT
admet-275	49	21	usa	usa	PROPN
admet-275	49	22	)	)	PUNCT
admet-275	49	23	.	.	PUNCT
admet-275	50	1	desipramine	desipramine	PROPN
admet-275	50	2	was	be	AUX
admet-275	50	3	from	from	ADP
admet-275	50	4	icn	icn	PROPN
admet-275	50	5	biochemicals	biochemical	NOUN
admet-275	50	6	(	(	PUNCT
admet-275	50	7	aurora	aurora	PROPN
admet-275	50	8	,	,	PUNCT
admet-275	50	9	oh	oh	INTJ
admet-275	50	10	,	,	PUNCT
admet-275	50	11	usa	usa	PROPN
admet-275	50	12	)	)	PUNCT
admet-275	50	13	.	.	PUNCT
admet-275	51	1	all	all	PRON
admet-275	51	2	above	above	ADP
admet-275	51	3	drugs	drug	NOUN
admet-275	51	4	were	be	AUX
admet-275	51	5	ultimately	ultimately	ADV
admet-275	51	6	diluted	dilute	VERB
admet-275	51	7	in	in	ADP
admet-275	51	8	dmso	dmso	NOUN
admet-275	51	9	.	.	PUNCT
admet-275	52	1	dulbecco	dulbecco	PROPN
admet-275	52	2	’s	’s	PART
admet-275	52	3	modified	modified	PROPN
admet-275	52	4	eagle	eagle	PROPN
admet-275	52	5	medium	medium	NOUN
admet-275	52	6	(	(	PUNCT
admet-275	52	7	dmem	dmem	ADJ
admet-275	52	8	)	)	PUNCT
admet-275	52	9	,	,	PUNCT
admet-275	52	10	trypsin	trypsin	NOUN
admet-275	52	11	-	-	PUNCT
admet-275	52	12	edta	edta	NOUN
admet-275	52	13	,	,	PUNCT
admet-275	52	14	penicillin	penicillin	NOUN
admet-275	52	15	/	/	SYM
admet-275	52	16	streptomycin	streptomycin	PROPN
admet-275	52	17	(	(	PUNCT
admet-275	52	18	p	p	X
admet-275	52	19	/	/	SYM
admet-275	52	20	s	s	NOUN
admet-275	52	21	;	;	PUNCT
admet-275	52	22	10000	10000	NUM
admet-275	52	23	u	u	NOUN
admet-275	52	24	/	/	SYM
admet-275	52	25	ml	ml	NOUN
admet-275	52	26	)	)	PUNCT
admet-275	52	27	and	and	CCONJ
admet-275	52	28	1	1	NUM
admet-275	52	29	m	m	NOUN
admet-275	52	30	hepes	hepe	NOUN
admet-275	52	31	buffer	buffer	NOUN
admet-275	52	32	(	(	PUNCT
admet-275	52	33	in	in	ADP
admet-275	52	34	0.85	0.85	NUM
admet-275	52	35	%	%	NOUN
admet-275	52	36	nacl	nacl	NOUN
admet-275	52	37	)	)	PUNCT
admet-275	52	38	were	be	AUX
admet-275	52	39	purchased	purchase	VERB
admet-275	52	40	from	from	ADP
admet-275	52	41	lonza	lonza	PROPN
admet-275	52	42	benelux	benelux	PROPN
admet-275	52	43	bv	bv	PROPN
admet-275	52	44	(	(	PUNCT
admet-275	52	45	breda	breda	PROPN
admet-275	52	46	,	,	PUNCT
admet-275	52	47	the	the	DET
admet-275	52	48	netherlands	netherlands	PROPN
admet-275	52	49	)	)	PUNCT
admet-275	52	50	.	.	PUNCT
admet-275	53	1	phosphate	phosphate	VERB
admet-275	53	2	buffered	buffer	VERB
admet-275	53	3	saline	saline	NOUN
admet-275	53	4	(	(	PUNCT
admet-275	53	5	pbs	pbs	PROPN
admet-275	53	6	)	)	PUNCT
admet-275	53	7	was	be	AUX
admet-275	53	8	purchased	purchase	VERB
admet-275	53	9	from	from	ADP
admet-275	53	10	b.	b.	PROPN
admet-275	53	11	braun	braun	PROPN
admet-275	53	12	medical	medical	PROPN
admet-275	53	13	bv	bv	PROPN
admet-275	53	14	(	(	PUNCT
admet-275	53	15	oss	oss	PROPN
admet-275	53	16	,	,	PUNCT
admet-275	53	17	the	the	DET
admet-275	53	18	netherlands	netherlands	PROPN
admet-275	53	19	)	)	PUNCT
admet-275	53	20	.	.	PUNCT
admet-275	54	1	fetal	fetal	ADJ
admet-275	54	2	bovine	bovine	NOUN
admet-275	54	3	serum	serum	NOUN
admet-275	54	4	(	(	PUNCT
admet-275	54	5	fbs	fbs	PROPN
admet-275	54	6	)	)	PUNCT
admet-275	54	7	was	be	AUX
admet-275	54	8	purchased	purchase	VERB
admet-275	54	9	from	from	ADP
admet-275	54	10	paa	paa	PROPN
admet-275	54	11	laboratories	laboratory	NOUN
admet-275	54	12	gmbh	gmbh	PROPN
admet-275	54	13	(	(	PUNCT
admet-275	54	14	pasching	pasching	NOUN
admet-275	54	15	,	,	PUNCT
admet-275	54	16	austria	austria	PROPN
admet-275	54	17	)	)	PUNCT
admet-275	54	18	.	.	PUNCT
admet-275	55	1	bovine	bovine	PROPN
admet-275	55	2	serum	serum	NOUN
admet-275	55	3	albumin	albumin	PROPN
admet-275	55	4	fraktion	fraktion	NOUN
admet-275	55	5	v	v	NOUN
admet-275	55	6	(	(	PUNCT
admet-275	55	7	bsa	bsa	PROPN
admet-275	55	8	)	)	PUNCT
admet-275	55	9	was	be	AUX
admet-275	55	10	purchased	purchase	VERB
admet-275	55	11	from	from	ADP
admet-275	55	12	roche	roche	PROPN
admet-275	55	13	diagnostics	diagnostic	NOUN
admet-275	55	14	gmbh	gmbh	NOUN
admet-275	55	15	(	(	PUNCT
admet-275	55	16	mannheim	mannheim	PROPN
admet-275	55	17	,	,	PUNCT
admet-275	55	18	germany	germany	PROPN
admet-275	55	19	)	)	PUNCT
admet-275	55	20	.	.	PUNCT
admet-275	56	1	analytical	analytical	ADJ
admet-275	56	2	grade	grade	NOUN
admet-275	56	3	solvents	solvent	NOUN
admet-275	56	4	like	like	ADP
admet-275	56	5	acetonitrile	acetonitrile	NOUN
admet-275	56	6	,	,	PUNCT
admet-275	56	7	methanol	methanol	NOUN
admet-275	56	8	and	and	CCONJ
admet-275	56	9	isopropanol	isopropanol	NOUN
admet-275	56	10	were	be	AUX
admet-275	56	11	purchased	purchase	VERB
admet-275	56	12	from	from	ADP
admet-275	56	13	biosolve	biosolve	NOUN
admet-275	56	14	bv	bv	PROPN
admet-275	56	15	(	(	PUNCT
admet-275	56	16	valkenswaard	valkenswaard	PROPN
admet-275	56	17	,	,	PUNCT
admet-275	56	18	the	the	DET
admet-275	56	19	netherlands	netherlands	PROPN
admet-275	56	20	)	)	PUNCT
admet-275	56	21	.	.	PUNCT
admet-275	57	1	bio	bio	PROPN
admet-275	57	2	-	-	ADJ
admet-275	57	3	rad	rad	PROPN
admet-275	57	4	protein	protein	NOUN
admet-275	57	5	assay	assay	NOUN
admet-275	57	6	was	be	AUX
admet-275	57	7	purchased	purchase	VERB
admet-275	57	8	from	from	ADP
admet-275	57	9	bio	bio	PROPN
admet-275	57	10	-	-	ADJ
admet-275	57	11	rad	rad	ADJ
admet-275	57	12	laboratories	laboratory	NOUN
admet-275	57	13	gmbh	gmbh	PROPN
admet-275	57	14	(	(	PUNCT
admet-275	57	15	münchen	münchen	PROPN
admet-275	57	16	,	,	PUNCT
admet-275	57	17	germany	germany	PROPN
admet-275	57	18	)	)	PUNCT
admet-275	57	19	.	.	PUNCT
admet-275	58	1	milliq	milliq	PROPN
admet-275	58	2	water	water	NOUN
admet-275	58	3	was	be	AUX
admet-275	58	4	supplied	supply	VERB
admet-275	58	5	via	via	ADP
admet-275	58	6	a	a	DET
admet-275	58	7	milliq	milliq	ADJ
admet-275	58	8	water	water	NOUN
admet-275	58	9	purification	purification	NOUN
admet-275	58	10	system	system	NOUN
admet-275	58	11	(	(	PUNCT
admet-275	58	12	millipore	millipore	PROPN
admet-275	58	13	,	,	PUNCT
admet-275	58	14	the	the	DET
admet-275	58	15	netherlands	netherlands	PROPN
admet-275	58	16	)	)	PUNCT
admet-275	58	17	.	.	PUNCT
admet-275	59	1	the	the	DET
admet-275	59	2	biocoat	biocoat	PROPN
admet-275	59	3	®	®	PROPN
admet-275	59	4	hts	hts	PROPN
admet-275	59	5	caco-2	caco-2	NUM
admet-275	59	6	assay	assay	NOUN
admet-275	59	7	system	system	NOUN
admet-275	59	8	was	be	AUX
admet-275	59	9	purchased	purchase	VERB
admet-275	59	10	from	from	ADP
admet-275	59	11	becton	becton	PROPN
admet-275	59	12	dickinson	dickinson	PROPN
admet-275	59	13	bv	bv	PROPN
admet-275	59	14	(	(	PUNCT
admet-275	59	15	breda	breda	PROPN
admet-275	59	16	,	,	PUNCT
admet-275	59	17	the	the	DET
admet-275	59	18	netherlands	netherlands	PROPN
admet-275	59	19	)	)	PUNCT
admet-275	59	20	.	.	PUNCT
admet-275	60	1	breathe	breathe	ADJ
admet-275	60	2	-	-	PUNCT
admet-275	60	3	easy	easy	ADJ
admet-275	60	4	microplate	microplate	NOUN
admet-275	60	5	sealing	seal	VERB
admet-275	60	6	film	film	NOUN
admet-275	60	7	was	be	AUX
admet-275	60	8	purchased	purchase	VERB
admet-275	60	9	from	from	ADP
admet-275	60	10	diversified	diversified	ADJ
admet-275	60	11	biotech	biotech	NOUN
admet-275	60	12	bv	bv	PROPN
admet-275	60	13	(	(	PUNCT
admet-275	60	14	ulvenhout	ulvenhout	PROPN
admet-275	60	15	,	,	PUNCT
admet-275	60	16	the	the	DET
admet-275	60	17	netherlands	netherlands	PROPN
admet-275	60	18	)	)	PUNCT
admet-275	60	19	.	.	PUNCT
admet-275	61	1	the	the	DET
admet-275	61	2	trans	trans	PROPN
admet-275	61	3	epithelial	epithelial	ADJ
admet-275	61	4	electrical	electrical	ADJ
admet-275	61	5	resistance	resistance	NOUN
admet-275	61	6	(	(	PUNCT
admet-275	61	7	teer	teer	NOUN
admet-275	61	8	)	)	PUNCT
admet-275	61	9	meter	meter	NOUN
admet-275	61	10	(	(	PUNCT
admet-275	61	11	millicell	millicell	PROPN
admet-275	61	12	®	®	NOUN
admet-275	61	13	–	–	PUNCT
admet-275	61	14	ers	er	NOUN
admet-275	61	15	)	)	PUNCT
admet-275	61	16	was	be	AUX
admet-275	61	17	provided	provide	VERB
admet-275	61	18	by	by	ADP
admet-275	61	19	millipore	millipore	PROPN
admet-275	61	20	(	(	PUNCT
admet-275	61	21	amsterdam	amsterdam	PROPN
admet-275	61	22	,	,	PUNCT
admet-275	61	23	the	the	DET
admet-275	61	24	netherlands	netherlands	PROPN
admet-275	61	25	)	)	PUNCT
admet-275	61	26	.	.	PUNCT
admet-275	62	1	lc	lc	PROPN
admet-275	62	2	-	-	PUNCT
admet-275	62	3	ms	ms	PROPN
admet-275	62	4	/	/	SYM
admet-275	62	5	ms	ms	PROPN
admet-275	62	6	analyses	analysis	NOUN
admet-275	62	7	were	be	AUX
admet-275	62	8	performed	perform	VERB
admet-275	62	9	using	use	VERB
admet-275	62	10	a	a	DET
admet-275	62	11	dionex	dionex	ADV
admet-275	62	12	ultimate	ultimate	ADJ
admet-275	62	13	3000	3000	NUM
admet-275	62	14	system	system	NOUN
admet-275	62	15	coupled	couple	VERB
admet-275	62	16	with	with	ADP
admet-275	62	17	an	an	DET
admet-275	62	18	api	api	NOUN
admet-275	62	19	3000	3000	NUM
admet-275	62	20	mass	mass	NOUN
admet-275	62	21	spectrometer	spectrometer	NOUN
admet-275	62	22	(	(	PUNCT
admet-275	62	23	applied	apply	VERB
admet-275	62	24	biosciences	bioscience	NOUN
admet-275	62	25	sciex	sciex	NOUN
admet-275	62	26	)	)	PUNCT
admet-275	62	27	.	.	PUNCT
admet-275	63	1	for	for	ADP
admet-275	63	2	this	this	DET
admet-275	63	3	system	system	NOUN
admet-275	63	4	the	the	DET
admet-275	63	5	following	follow	VERB
admet-275	63	6	software	software	NOUN
admet-275	63	7	was	be	AUX
admet-275	63	8	used	use	VERB
admet-275	63	9	:	:	PUNCT
admet-275	63	10	analyst	analyst	NOUN
admet-275	63	11	version	version	NOUN
admet-275	63	12	1.5.2	1.5.2	NUM
admet-275	63	13	from	from	ADP
admet-275	63	14	applied	apply	VERB
admet-275	63	15	biosciences	bioscience	NOUN
admet-275	63	16	in	in	ADP
admet-275	63	17	combination	combination	NOUN
admet-275	63	18	with	with	ADP
admet-275	63	19	dionex	dionex	NOUN
admet-275	63	20	,	,	PUNCT
admet-275	63	21	chromeleon	chromeleon	NOUN
admet-275	63	22	lc	lc	PROPN
admet-275	63	23	modules	module	NOUN
admet-275	63	24	version	version	NOUN
admet-275	63	25	6.8	6.8	NUM
admet-275	63	26	,	,	PUNCT
admet-275	63	27	controlled	control	VERB
admet-275	63	28	by	by	ADP
admet-275	63	29	dionex	dionex	PROPN
admet-275	63	30	mass	mass	PROPN
admet-275	63	31	link	link	NOUN
admet-275	63	32	(	(	PUNCT
admet-275	63	33	dms	dms	NOUN
admet-275	63	34	)	)	PUNCT
admet-275	63	35	version	version	NOUN
admet-275	63	36	2.10	2.10	NUM
admet-275	63	37	.	.	PUNCT
admet-275	64	1	admet	admet	PROPN
admet-275	64	2	&	&	CCONJ
admet-275	64	3	dmpk	dmpk	PROPN
admet-275	64	4	4(1	4(1	NOUN
admet-275	64	5	)	)	PUNCT
admet-275	64	6	(	(	PUNCT
admet-275	64	7	2016	2016	NUM
admet-275	64	8	)	)	PUNCT
admet-275	64	9	23	23	NUM
admet-275	64	10	-	-	SYM
admet-275	64	11	34	34	NUM
admet-275	64	12	transport	transport	NOUN
admet-275	64	13	mechanism	mechanism	NOUN
admet-275	64	14	of	of	ADP
admet-275	64	15	tk	tk	PROPN
admet-275	64	16	inhibitors	inhibitor	NOUN
admet-275	64	17	doi	doi	NOUN
admet-275	64	18	:	:	PUNCT
admet-275	64	19	10.5599	10.5599	NUM
admet-275	64	20	/	/	SYM
admet-275	64	21	admet.4.1.275	admet.4.1.275	PROPN
admet-275	64	22	25	25	NUM
admet-275	64	23	cell	cell	NOUN
admet-275	64	24	culture	culture	NOUN
admet-275	64	25	the	the	DET
admet-275	64	26	caco-2	caco-2	NUM
admet-275	64	27	cell	cell	NOUN
admet-275	64	28	line	line	NOUN
admet-275	64	29	,	,	PUNCT
admet-275	64	30	originating	originate	VERB
admet-275	64	31	from	from	ADP
admet-275	64	32	a	a	DET
admet-275	64	33	colorectal	colorectal	ADJ
admet-275	64	34	adenocarcinoma	adenocarcinoma	NOUN
admet-275	64	35	,	,	PUNCT
admet-275	64	36	was	be	AUX
admet-275	64	37	cultured	cultured	ADJ
admet-275	64	38	in	in	ADP
admet-275	64	39	dmem	dmem	ADJ
admet-275	64	40	supplemented	supplement	VERB
admet-275	64	41	with	with	ADP
admet-275	64	42	10	10	NUM
admet-275	64	43	%	%	NOUN
admet-275	64	44	fbs	fbs	ADJ
admet-275	64	45	and	and	CCONJ
admet-275	64	46	20	20	NUM
admet-275	64	47	mm	mm	PROPN
admet-275	64	48	hepes	hepe	NOUN
admet-275	64	49	at	at	ADP
admet-275	64	50	37	37	NUM
admet-275	64	51	°	°	NOUN
admet-275	64	52	c	c	NOUN
admet-275	64	53	,	,	PUNCT
admet-275	64	54	5	5	NUM
admet-275	64	55	%	%	NOUN
admet-275	64	56	co2	co2	NOUN
admet-275	64	57	and	and	CCONJ
admet-275	64	58	100	100	NUM
admet-275	64	59	%	%	NOUN
admet-275	64	60	humidity	humidity	NOUN
admet-275	65	1	[	[	X
admet-275	65	2	31,33	31,33	NUM
admet-275	65	3	]	]	PUNCT
admet-275	65	4	.	.	PUNCT
admet-275	66	1	under	under	ADP
admet-275	66	2	normal	normal	ADJ
admet-275	66	3	culture	culture	NOUN
admet-275	66	4	conditions	condition	NOUN
admet-275	66	5	caco-2	caco-2	NUM
admet-275	66	6	cells	cell	NOUN
admet-275	66	7	behave	behave	VERB
admet-275	66	8	like	like	ADP
admet-275	66	9	a	a	DET
admet-275	66	10	colon	colon	NOUN
admet-275	66	11	cancer	cancer	NOUN
admet-275	66	12	cell	cell	NOUN
admet-275	66	13	in	in	ADP
admet-275	66	14	which	which	PRON
admet-275	66	15	no	no	DET
admet-275	66	16	polarization	polarization	NOUN
admet-275	66	17	at	at	ADP
admet-275	66	18	apical	apical	ADJ
admet-275	66	19	or	or	CCONJ
admet-275	66	20	basolateral	basolateral	ADJ
admet-275	66	21	side	side	NOUN
admet-275	66	22	is	be	AUX
admet-275	66	23	found	find	VERB
admet-275	66	24	.	.	PUNCT
admet-275	67	1	using	use	VERB
admet-275	67	2	a	a	DET
admet-275	67	3	special	special	ADJ
admet-275	67	4	coating	coating	NOUN
admet-275	67	5	in	in	ADP
admet-275	67	6	a	a	DET
admet-275	67	7	transwell	transwell	NOUN
admet-275	67	8	,	,	PUNCT
admet-275	67	9	the	the	DET
admet-275	67	10	cell	cell	NOUN
admet-275	67	11	line	line	NOUN
admet-275	67	12	differentiates	differentiate	NOUN
admet-275	67	13	and	and	CCONJ
admet-275	67	14	when	when	SCONJ
admet-275	67	15	confluent	confluent	ADJ
admet-275	67	16	,	,	PUNCT
admet-275	67	17	forms	form	VERB
admet-275	67	18	a	a	DET
admet-275	67	19	cellular	cellular	ADJ
admet-275	67	20	layer	layer	NOUN
admet-275	67	21	with	with	ADP
admet-275	67	22	specific	specific	ADJ
admet-275	67	23	transporter	transporter	NOUN
admet-275	67	24	expression	expression	NOUN
admet-275	67	25	at	at	ADP
admet-275	67	26	each	each	DET
admet-275	67	27	side	side	NOUN
admet-275	67	28	(	(	PUNCT
admet-275	67	29	figure	figure	NOUN
admet-275	67	30	1	1	NUM
admet-275	67	31	)	)	PUNCT
admet-275	67	32	.	.	PUNCT
admet-275	68	1	characterization	characterization	NOUN
admet-275	68	2	of	of	ADP
admet-275	68	3	passive	passive	ADJ
admet-275	68	4	and	and	CCONJ
admet-275	68	5	active	active	ADJ
admet-275	68	6	transport	transport	NOUN
admet-275	68	7	active	active	ADJ
admet-275	68	8	and	and	CCONJ
admet-275	68	9	passive	passive	ADJ
admet-275	68	10	transport	transport	NOUN
admet-275	68	11	were	be	AUX
admet-275	68	12	characterized	characterize	VERB
admet-275	68	13	by	by	ADP
admet-275	68	14	culturing	culture	VERB
admet-275	68	15	the	the	DET
admet-275	68	16	cells	cell	NOUN
admet-275	68	17	at	at	ADP
admet-275	68	18	a	a	DET
admet-275	68	19	low	low	ADJ
admet-275	68	20	temperature	temperature	NOUN
admet-275	68	21	(	(	PUNCT
admet-275	68	22	4	4	NUM
admet-275	68	23	°	°	NOUN
admet-275	68	24	c	c	NOUN
admet-275	68	25	;	;	PUNCT
admet-275	68	26	passive	passive	ADJ
admet-275	68	27	transport	transport	NOUN
admet-275	68	28	)	)	PUNCT
admet-275	68	29	or	or	CCONJ
admet-275	68	30	a	a	DET
admet-275	68	31	physiological	physiological	ADJ
admet-275	68	32	temperature	temperature	NOUN
admet-275	68	33	(	(	PUNCT
admet-275	68	34	37	37	NUM
admet-275	68	35	°	°	NOUN
admet-275	68	36	c	c	NOUN
admet-275	68	37	;	;	PUNCT
admet-275	68	38	active	active	ADJ
admet-275	68	39	and	and	CCONJ
admet-275	68	40	passive	passive	ADJ
admet-275	68	41	transport	transport	NOUN
admet-275	68	42	)	)	PUNCT
admet-275	68	43	.	.	PUNCT
admet-275	69	1	caco-2	caco-2	NUM
admet-275	69	2	cells	cell	NOUN
admet-275	69	3	were	be	AUX
admet-275	69	4	seeded	seed	VERB
admet-275	69	5	in	in	ADP
admet-275	69	6	2	2	NUM
admet-275	69	7	ml	ml	NOUN
admet-275	69	8	dmem	dmem	VERB
admet-275	69	9	culture	culture	NOUN
admet-275	69	10	medium	medium	NOUN
admet-275	69	11	with	with	ADP
admet-275	69	12	1	1	NUM
admet-275	69	13	%	%	NOUN
admet-275	69	14	penicillin	penicillin	NOUN
admet-275	69	15	/	/	SYM
admet-275	69	16	streptomycin	streptomycin	PROPN
admet-275	69	17	(	(	PUNCT
admet-275	69	18	p	p	X
admet-275	69	19	/	/	SYM
admet-275	69	20	s	s	NOUN
admet-275	69	21	)	)	PUNCT
admet-275	69	22	in	in	ADP
admet-275	69	23	6	6	NUM
admet-275	69	24	-	-	PUNCT
admet-275	69	25	well	well	NOUN
admet-275	69	26	plates	plate	NOUN
admet-275	69	27	at	at	ADP
admet-275	69	28	a	a	DET
admet-275	69	29	density	density	NOUN
admet-275	69	30	of	of	ADP
admet-275	69	31	0.2	0.2	NUM
admet-275	69	32	x	x	SYM
admet-275	69	33	105	105	NUM
admet-275	69	34	cells	cell	NOUN
admet-275	69	35	/	/	SYM
admet-275	69	36	cm2	cm2	NOUN
admet-275	69	37	.	.	PUNCT
admet-275	69	38	cells	cell	NOUN
admet-275	69	39	were	be	AUX
admet-275	69	40	allowed	allow	VERB
admet-275	69	41	to	to	PART
admet-275	69	42	attach	attach	VERB
admet-275	69	43	for	for	ADP
admet-275	69	44	36	36	NUM
admet-275	69	45	hours	hour	NOUN
admet-275	69	46	at	at	ADP
admet-275	69	47	37	37	NUM
admet-275	69	48	°	°	NOUN
admet-275	69	49	c	c	NOUN
admet-275	69	50	,	,	PUNCT
admet-275	69	51	5	5	NUM
admet-275	69	52	%	%	NOUN
admet-275	69	53	co2	co2	NOUN
admet-275	69	54	and	and	CCONJ
admet-275	69	55	100	100	NUM
admet-275	69	56	%	%	NOUN
admet-275	69	57	humidity	humidity	NOUN
admet-275	69	58	.	.	PUNCT
admet-275	70	1	subsequently	subsequently	ADV
admet-275	70	2	,	,	PUNCT
admet-275	70	3	cells	cell	NOUN
admet-275	70	4	were	be	AUX
admet-275	70	5	incubated	incubate	VERB
admet-275	70	6	at	at	ADP
admet-275	70	7	4	4	NUM
admet-275	70	8	°	°	NOUN
admet-275	70	9	c	c	NOUN
admet-275	70	10	or	or	CCONJ
admet-275	70	11	at	at	ADP
admet-275	70	12	37	37	NUM
admet-275	70	13	°	°	NOUN
admet-275	70	14	c	c	NOUN
admet-275	70	15	for	for	ADP
admet-275	70	16	two	two	NUM
admet-275	70	17	hours	hour	NOUN
admet-275	70	18	prior	prior	ADV
admet-275	70	19	to	to	ADP
admet-275	70	20	the	the	DET
admet-275	70	21	experiment	experiment	NOUN
admet-275	70	22	.	.	PUNCT
admet-275	71	1	attached	attach	VERB
admet-275	71	2	cells	cell	NOUN
admet-275	71	3	were	be	AUX
admet-275	71	4	than	than	SCONJ
admet-275	71	5	exposed	expose	VERB
admet-275	71	6	to	to	ADP
admet-275	71	7	10	10	NUM
admet-275	71	8	µm	µm	ADP
admet-275	71	9	erlotinib	erlotinib	NOUN
admet-275	71	10	,	,	PUNCT
admet-275	71	11	gefitinib	gefitinib	NOUN
admet-275	71	12	,	,	PUNCT
admet-275	71	13	sorafenib	sorafenib	NOUN
admet-275	71	14	,	,	PUNCT
admet-275	71	15	sunitinib	sunitinib	NOUN
admet-275	71	16	,	,	PUNCT
admet-275	71	17	crizotinib	crizotinib	VERB
admet-275	71	18	and	and	CCONJ
admet-275	71	19	1	1	NUM
admet-275	71	20	µm	µm	ADP
admet-275	71	21	dasatinib	dasatinib	NOUN
admet-275	71	22	for	for	ADP
admet-275	71	23	2	2	NUM
admet-275	71	24	,	,	PUNCT
admet-275	71	25	4	4	NUM
admet-275	71	26	and	and	CCONJ
admet-275	71	27	6	6	NUM
admet-275	71	28	hours	hour	NOUN
admet-275	71	29	at	at	ADP
admet-275	71	30	both	both	PRON
admet-275	71	31	4	4	NUM
admet-275	71	32	°	°	NOUN
admet-275	71	33	c	c	NOUN
admet-275	71	34	and	and	CCONJ
admet-275	71	35	37	37	NUM
admet-275	71	36	°	°	NOUN
admet-275	71	37	c	c	NOUN
admet-275	71	38	.	.	PUNCT
admet-275	72	1	after	after	SCONJ
admet-275	72	2	drug	drug	NOUN
admet-275	72	3	exposure	exposure	NOUN
admet-275	72	4	medium	medium	NOUN
admet-275	72	5	was	be	AUX
admet-275	72	6	aspirated	aspirate	VERB
admet-275	72	7	and	and	CCONJ
admet-275	72	8	cells	cell	NOUN
admet-275	72	9	were	be	AUX
admet-275	72	10	washed	wash	VERB
admet-275	72	11	three	three	NUM
admet-275	72	12	times	time	NOUN
admet-275	72	13	with	with	ADP
admet-275	72	14	5	5	NUM
admet-275	72	15	ml	ml	NOUN
admet-275	72	16	ice	ice	PROPN
admet-275	72	17	cold	cold	PROPN
admet-275	72	18	pbs	pbs	PROPN
admet-275	72	19	.	.	PUNCT
admet-275	73	1	trypsin	trypsin	PROPN
admet-275	73	2	/	/	SYM
admet-275	73	3	edta	edta	PROPN
admet-275	73	4	(	(	PUNCT
admet-275	73	5	200	200	NUM
admet-275	73	6	µl	µl	NOUN
admet-275	73	7	)	)	PUNCT
admet-275	73	8	was	be	AUX
admet-275	73	9	added	add	VERB
admet-275	73	10	to	to	ADP
admet-275	73	11	each	each	DET
admet-275	73	12	well	well	ADV
admet-275	73	13	and	and	CCONJ
admet-275	73	14	incubated	incubate	VERB
admet-275	73	15	for	for	ADP
admet-275	73	16	about	about	ADV
admet-275	73	17	5	5	NUM
admet-275	73	18	-	-	SYM
admet-275	73	19	10	10	NUM
admet-275	73	20	minutes	minute	NOUN
admet-275	73	21	at	at	ADP
admet-275	73	22	37	37	NUM
admet-275	73	23	°	°	NOUN
admet-275	73	24	c	c	NOUN
admet-275	73	25	,	,	PUNCT
admet-275	73	26	5	5	NUM
admet-275	73	27	%	%	NOUN
admet-275	73	28	co2	co2	NOUN
admet-275	73	29	and	and	CCONJ
admet-275	73	30	100	100	NUM
admet-275	73	31	%	%	NOUN
admet-275	73	32	humidity	humidity	NOUN
admet-275	73	33	.	.	PUNCT
admet-275	74	1	when	when	SCONJ
admet-275	74	2	cells	cell	NOUN
admet-275	74	3	were	be	AUX
admet-275	74	4	detached	detach	VERB
admet-275	74	5	,	,	PUNCT
admet-275	74	6	the	the	DET
admet-275	74	7	cells	cell	NOUN
admet-275	74	8	were	be	AUX
admet-275	74	9	re	re	VERB
admet-275	74	10	-	-	VERB
admet-275	74	11	suspended	suspend	VERB
admet-275	74	12	with	with	ADP
admet-275	74	13	1	1	NUM
admet-275	74	14	ml	ml	NOUN
admet-275	74	15	ice	ice	NOUN
admet-275	74	16	cold	cold	ADJ
admet-275	74	17	pbs	pbs	PROPN
admet-275	74	18	and	and	CCONJ
admet-275	74	19	transferred	transfer	VERB
admet-275	74	20	into	into	ADP
admet-275	74	21	eppendorf	eppendorf	PROPN
admet-275	74	22	tubes	tube	NOUN
admet-275	74	23	.	.	PUNCT
admet-275	75	1	next	next	ADV
admet-275	75	2	,	,	PUNCT
admet-275	75	3	cell	cell	NOUN
admet-275	75	4	suspension	suspension	NOUN
admet-275	75	5	was	be	AUX
admet-275	75	6	spun	spin	VERB
admet-275	75	7	down	down	ADP
admet-275	75	8	for	for	ADP
admet-275	75	9	5	5	NUM
admet-275	75	10	minutes	minute	NOUN
admet-275	75	11	at	at	ADP
admet-275	75	12	425	425	NUM
admet-275	75	13	g	g	NOUN
admet-275	75	14	at	at	ADP
admet-275	75	15	4	4	NUM
admet-275	75	16	°	°	NOUN
admet-275	75	17	c	c	NOUN
admet-275	75	18	.	.	PUNCT
admet-275	76	1	at	at	ADP
admet-275	76	2	last	last	ADJ
admet-275	76	3	the	the	DET
admet-275	76	4	supernatant	supernatant	NOUN
admet-275	76	5	was	be	AUX
admet-275	76	6	aspirated	aspirate	VERB
admet-275	76	7	,	,	PUNCT
admet-275	76	8	the	the	DET
admet-275	76	9	pellet	pellet	NOUN
admet-275	76	10	was	be	AUX
admet-275	76	11	snap	snap	ADJ
admet-275	76	12	frozen	freeze	VERB
admet-275	76	13	in	in	ADP
admet-275	76	14	liquid	liquid	ADJ
admet-275	76	15	nitrogen	nitrogen	NOUN
admet-275	76	16	and	and	CCONJ
admet-275	76	17	stored	store	VERB
admet-275	76	18	at	at	ADP
admet-275	76	19	-80	-80	NOUN
admet-275	76	20	°	°	NOUN
admet-275	76	21	c	c	NOUN
admet-275	76	22	,	,	PUNCT
admet-275	76	23	until	until	ADP
admet-275	76	24	analysis	analysis	NOUN
admet-275	76	25	by	by	ADP
admet-275	76	26	the	the	DET
admet-275	76	27	liquid	liquid	ADJ
admet-275	76	28	chromatography	chromatography	NOUN
admet-275	76	29	coupled	couple	VERB
admet-275	76	30	to	to	ADP
admet-275	76	31	mass	mass	ADJ
admet-275	76	32	spectrometry	spectrometry	NOUN
admet-275	76	33	(	(	PUNCT
admet-275	76	34	lc	lc	PROPN
admet-275	76	35	-	-	PUNCT
admet-275	76	36	ms	ms	PROPN
admet-275	76	37	-	-	PUNCT
admet-275	76	38	ms	ms	NOUN
admet-275	76	39	)	)	PUNCT
admet-275	77	1	[	[	X
admet-275	77	2	34	34	NUM
admet-275	77	3	]	]	PUNCT
admet-275	77	4	.	.	PUNCT
admet-275	78	1	the	the	DET
admet-275	78	2	protein	protein	NOUN
admet-275	78	3	content	content	NOUN
admet-275	78	4	was	be	AUX
admet-275	78	5	determined	determine	VERB
admet-275	78	6	using	use	VERB
admet-275	78	7	the	the	DET
admet-275	78	8	bio	bio	NOUN
admet-275	78	9	-	-	ADJ
admet-275	78	10	rad	rad	ADJ
admet-275	78	11	protein	protein	NOUN
admet-275	78	12	assay	assay	VERB
admet-275	78	13	.	.	PUNCT
admet-275	79	1	figure	figure	NOUN
admet-275	79	2	1	1	NUM
admet-275	79	3	.	.	PUNCT
admet-275	80	1	caco-2	caco-2	NUM
admet-275	80	2	cell	cell	NOUN
admet-275	80	3	culture	culture	NOUN
admet-275	80	4	system	system	NOUN
admet-275	80	5	with	with	ADP
admet-275	80	6	an	an	DET
admet-275	80	7	apical	apical	ADJ
admet-275	80	8	(	(	PUNCT
admet-275	80	9	intestine	intestine	NOUN
admet-275	80	10	)	)	PUNCT
admet-275	80	11	and	and	CCONJ
admet-275	80	12	basolateral	basolateral	ADJ
admet-275	80	13	(	(	PUNCT
admet-275	80	14	blood	blood	NOUN
admet-275	80	15	)	)	PUNCT
admet-275	80	16	side[35	side[35	NOUN
admet-275	80	17	]	]	PUNCT
admet-275	80	18	.	.	PUNCT
admet-275	81	1	effect	effect	NOUN
admet-275	81	2	of	of	ADP
admet-275	81	3	specific	specific	ADJ
admet-275	81	4	oct	oct	NOUN
admet-275	81	5	inhibitors	inhibitor	NOUN
admet-275	81	6	transporter	transporter	NOUN
admet-275	81	7	inhibition	inhibition	NOUN
admet-275	81	8	studies	study	NOUN
admet-275	81	9	were	be	AUX
admet-275	81	10	performed	perform	VERB
admet-275	81	11	to	to	PART
admet-275	81	12	determine	determine	VERB
admet-275	81	13	whether	whether	SCONJ
admet-275	81	14	the	the	DET
admet-275	81	15	human	human	ADJ
admet-275	81	16	organic	organic	ADJ
admet-275	81	17	cation	cation	NOUN
admet-275	81	18	transport	transport	NOUN
admet-275	81	19	(	(	PUNCT
admet-275	81	20	hoct	hoct	NOUN
admet-275	81	21	)	)	PUNCT
admet-275	81	22	family	family	NOUN
admet-275	81	23	is	be	AUX
admet-275	81	24	involved	involve	VERB
admet-275	81	25	in	in	ADP
admet-275	81	26	the	the	DET
admet-275	81	27	transport	transport	NOUN
admet-275	81	28	and	and	CCONJ
admet-275	81	29	accumulation	accumulation	NOUN
admet-275	81	30	of	of	ADP
admet-275	81	31	erlotinib	erlotinib	NOUN
admet-275	81	32	,	,	PUNCT
admet-275	81	33	gefitinib	gefitinib	NOUN
admet-275	81	34	,	,	PUNCT
admet-275	81	35	sorafenib	sorafenib	NOUN
admet-275	81	36	,	,	PUNCT
admet-275	81	37	sunitinib	sunitinib	NOUN
admet-275	81	38	,	,	PUNCT
admet-275	81	39	dasatinib	dasatinib	NOUN
admet-275	81	40	or	or	CCONJ
admet-275	81	41	crizotinib	crizotinib	VERB
admet-275	81	42	.	.	PUNCT
admet-275	82	1	to	to	PART
admet-275	82	2	achieve	achieve	VERB
admet-275	82	3	this	this	PRON
admet-275	82	4	,	,	PUNCT
admet-275	82	5	caco-2	caco-2	NUM
admet-275	82	6	cells	cell	NOUN
admet-275	82	7	were	be	AUX
admet-275	82	8	cultured	cultured	ADJ
admet-275	82	9	as	as	SCONJ
admet-275	82	10	described	describe	VERB
admet-275	82	11	above	above	ADV
admet-275	82	12	at	at	ADP
admet-275	82	13	37	37	NUM
admet-275	82	14	°	°	NOUN
admet-275	82	15	c	c	NOUN
admet-275	82	16	.	.	PUNCT
admet-275	83	1	after	after	ADP
admet-275	83	2	36	36	NUM
admet-275	83	3	hours	hour	NOUN
admet-275	83	4	,	,	PUNCT
admet-275	83	5	to	to	PART
admet-275	83	6	allow	allow	VERB
admet-275	83	7	proper	proper	ADJ
admet-275	83	8	attachment	attachment	NOUN
admet-275	83	9	,	,	PUNCT
admet-275	83	10	cells	cell	NOUN
admet-275	83	11	were	be	AUX
admet-275	83	12	exposed	expose	VERB
admet-275	83	13	to	to	ADP
admet-275	83	14	either	either	PRON
admet-275	83	15	100	100	NUM
admet-275	83	16	µm	µm	ADP
admet-275	83	17	amantadine	amantadine	NOUN
admet-275	83	18	(	(	PUNCT
admet-275	83	19	hoct1&2	hoct1&2	PROPN
admet-275	83	20	)	)	PUNCT
admet-275	83	21	,	,	PUNCT
admet-275	83	22	100	100	NUM
admet-275	83	23	µm	µm	ADP
admet-275	83	24	cimetidine	cimetidine	NOUN
admet-275	83	25	(	(	PUNCT
admet-275	83	26	hoct1&2&3	hoct1&2&3	X
admet-275	83	27	)	)	PUNCT
admet-275	84	1	[	[	X
admet-275	84	2	37	37	NUM
admet-275	84	3	]	]	PUNCT
admet-275	84	4	,	,	PUNCT
admet-275	84	5	100	100	NUM
admet-275	84	6	µm	µm	ADP
admet-275	84	7	desipramine	desipramine	NOUN
admet-275	84	8	(	(	PUNCT
admet-275	84	9	hoct1&2&3	hoct1&2&3	PROPN
admet-275	84	10	)	)	PUNCT
admet-275	84	11	,	,	PUNCT
admet-275	84	12	10	10	NUM
admet-275	84	13	µm	µm	ADP
admet-275	84	14	β	β	NOUN
admet-275	84	15	-	-	NOUN
admet-275	84	16	estradiol	estradiol	PROPN
admet-275	84	17	(	(	PUNCT
admet-275	84	18	hoct1&3	hoct1&3	PROPN
admet-275	84	19	)	)	PUNCT
admet-275	84	20	or	or	CCONJ
admet-275	84	21	10	10	NUM
admet-275	84	22	µm	µm	ADP
admet-275	84	23	verapamil	verapamil	NOUN
admet-275	84	24	(	(	PUNCT
admet-275	84	25	hoct1&p	hoct1&p	NOUN
admet-275	84	26	-	-	NOUN
admet-275	84	27	gp	gp	NOUN
admet-275	84	28	)	)	PUNCT
admet-275	85	1	[	[	X
admet-275	85	2	28,35,36	28,35,36	NUM
admet-275	85	3	]	]	PUNCT
admet-275	85	4	for	for	ADP
admet-275	85	5	15	15	NUM
admet-275	85	6	min	min	NOUN
admet-275	85	7	.	.	PROPN
admet-275	85	8	then	then	ADV
admet-275	85	9	attached	attach	VERB
admet-275	85	10	cells	cell	NOUN
admet-275	85	11	were	be	AUX
admet-275	85	12	exposed	expose	VERB
admet-275	85	13	to	to	ADP
admet-275	85	14	10	10	NUM
admet-275	85	15	µm	µm	ADP
admet-275	85	16	erlotinib	erlotinib	NOUN
admet-275	85	17	,	,	PUNCT
admet-275	85	18	gefitinib	gefitinib	NOUN
admet-275	85	19	,	,	PUNCT
admet-275	85	20	sorafenib	sorafenib	NOUN
admet-275	85	21	,	,	PUNCT
admet-275	85	22	sunitinib	sunitinib	NOUN
admet-275	85	23	,	,	PUNCT
admet-275	85	24	crizotinib	crizotinib	VERB
admet-275	85	25	or	or	CCONJ
admet-275	85	26	1	1	NUM
admet-275	85	27	µm	µm	ADP
admet-275	85	28	dasatinib	dasatinib	NOUN
admet-275	85	29	for	for	ADP
admet-275	85	30	2	2	NUM
admet-275	85	31	hours	hour	NOUN
admet-275	85	32	at	at	ADP
admet-275	85	33	37	37	NUM
admet-275	85	34	°	°	NOUN
admet-275	85	35	c	c	NOUN
admet-275	85	36	.	.	PUNCT
admet-275	86	1	after	after	SCONJ
admet-275	86	2	drug	drug	NOUN
admet-275	86	3	exposure	exposure	NOUN
admet-275	86	4	cells	cell	NOUN
admet-275	86	5	were	be	AUX
admet-275	86	6	harvested	harvest	VERB
admet-275	86	7	and	and	CCONJ
admet-275	86	8	processed	process	VERB
admet-275	86	9	as	as	SCONJ
admet-275	86	10	described	describe	VERB
admet-275	86	11	above	above	ADV
admet-275	86	12	.	.	PUNCT
admet-275	87	1	honeywell	honeywell	INTJ
admet-275	87	2	et	et	PROPN
admet-275	87	3	al	al	PROPN
admet-275	87	4	.	.	PROPN
admet-275	87	5	admet	admet	PROPN
admet-275	87	6	&	&	CCONJ
admet-275	87	7	dmpk	dmpk	PROPN
admet-275	87	8	4(1	4(1	NOUN
admet-275	87	9	)	)	PUNCT
admet-275	87	10	(	(	PUNCT
admet-275	87	11	2016	2016	NUM
admet-275	87	12	)	)	PUNCT
admet-275	87	13	23	23	NUM
admet-275	87	14	-	-	SYM
admet-275	87	15	34	34	NUM
admet-275	87	16	26	26	NUM
admet-275	87	17	differentiated	differentiate	VERB
admet-275	87	18	caco-2	caco-2	NUM
admet-275	87	19	cells	cell	NOUN
admet-275	87	20	as	as	ADP
admet-275	87	21	a	a	DET
admet-275	87	22	model	model	NOUN
admet-275	87	23	for	for	ADP
admet-275	87	24	gut	gut	VERB
admet-275	87	25	epithelial	epithelial	ADJ
admet-275	87	26	transport	transport	NOUN
admet-275	87	27	in	in	ADP
admet-275	87	28	transwell	transwell	NOUN
admet-275	87	29	transwell	transwell	NOUN
admet-275	87	30	studies	study	NOUN
admet-275	87	31	were	be	AUX
admet-275	87	32	performed	perform	VERB
admet-275	87	33	to	to	PART
admet-275	87	34	investigate	investigate	VERB
admet-275	87	35	the	the	DET
admet-275	87	36	transport	transport	NOUN
admet-275	87	37	of	of	ADP
admet-275	87	38	tkis	tkis	NOUN
admet-275	87	39	from	from	ADP
admet-275	87	40	apical	apical	ADJ
admet-275	87	41	(	(	PUNCT
admet-275	87	42	a	a	NOUN
admet-275	87	43	)	)	PUNCT
admet-275	87	44	to	to	ADP
admet-275	87	45	basolateral	basolateral	NOUN
admet-275	87	46	(	(	PUNCT
admet-275	87	47	b	b	NOUN
admet-275	87	48	)	)	PUNCT
admet-275	87	49	side	side	NOUN
admet-275	87	50	through	through	ADP
admet-275	87	51	a	a	DET
admet-275	87	52	confluent	confluent	ADJ
admet-275	87	53	caco-2	caco-2	NUM
admet-275	87	54	monolayer	monolayer	NOUN
admet-275	87	55	.	.	PUNCT
admet-275	88	1	the	the	DET
admet-275	88	2	optimization	optimization	NOUN
admet-275	88	3	and	and	CCONJ
admet-275	88	4	validation	validation	NOUN
admet-275	88	5	of	of	ADP
admet-275	88	6	this	this	DET
admet-275	88	7	model	model	NOUN
admet-275	88	8	was	be	AUX
admet-275	88	9	recently	recently	ADV
admet-275	88	10	described	describe	VERB
admet-275	88	11	[	[	X
admet-275	88	12	33	33	NUM
admet-275	88	13	]	]	PUNCT
admet-275	88	14	.	.	PUNCT
admet-275	89	1	shortly	shortly	ADV
admet-275	89	2	,	,	PUNCT
admet-275	89	3	the	the	DET
admet-275	89	4	becton	becton	PROPN
admet-275	89	5	dickinson	dickinson	PROPN
admet-275	89	6	bioscience	bioscience	PROPN
admet-275	89	7	biocoat	biocoat	PROPN
admet-275	89	8	®	®	PROPN
admet-275	89	9	hts	hts	PROPN
admet-275	89	10	caco-2	caco-2	NUM
admet-275	89	11	assay	assay	NOUN
admet-275	89	12	system	system	NOUN
admet-275	89	13	was	be	AUX
admet-275	89	14	used	use	VERB
admet-275	89	15	[	[	PUNCT
admet-275	89	16	37,38	37,38	NOUN
admet-275	89	17	]	]	PUNCT
admet-275	89	18	.	.	PUNCT
admet-275	90	1	caco-2	caco-2	NUM
admet-275	90	2	cells	cell	NOUN
admet-275	90	3	were	be	AUX
admet-275	90	4	plated	plate	VERB
admet-275	90	5	at	at	ADP
admet-275	90	6	a	a	DET
admet-275	90	7	density	density	NOUN
admet-275	90	8	of	of	ADP
admet-275	90	9	200,000	200,000	NUM
admet-275	90	10	cells	cell	NOUN
admet-275	90	11	per	per	ADP
admet-275	90	12	insert	insert	NOUN
admet-275	90	13	(	(	PUNCT
admet-275	90	14	6.6	6.6	NUM
admet-275	90	15	x	x	SYM
admet-275	90	16	105	105	NUM
admet-275	90	17	cells	cell	NOUN
admet-275	90	18	/	/	SYM
admet-275	90	19	cm2	cm2	NOUN
admet-275	90	20	)	)	PUNCT
admet-275	90	21	in	in	ADP
admet-275	90	22	500	500	NUM
admet-275	90	23	l	l	NOUN
admet-275	90	24	basal	basal	NOUN
admet-275	90	25	seeding	seed	VERB
admet-275	90	26	medium	medium	NOUN
admet-275	90	27	supplemented	supplement	VERB
admet-275	90	28	with	with	ADP
admet-275	90	29	0.1	0.1	NUM
admet-275	90	30	%	%	NOUN
admet-275	90	31	lyophilized	lyophilized	ADJ
admet-275	90	32	powder	powder	NOUN
admet-275	90	33	mito+	mito+	NOUN
admet-275	90	34	serum	serum	NOUN
admet-275	90	35	extender	extender	NOUN
admet-275	90	36	and	and	CCONJ
admet-275	90	37	1	1	NUM
admet-275	90	38	%	%	NOUN
admet-275	90	39	p	p	X
admet-275	90	40	/	/	SYM
admet-275	90	41	s	s	X
admet-275	90	42	(	(	PUNCT
admet-275	90	43	bsm	bsm	NOUN
admet-275	90	44	supplemented	supplement	VERB
admet-275	90	45	)	)	PUNCT
admet-275	90	46	.	.	PUNCT
admet-275	91	1	the	the	DET
admet-275	91	2	transwell	transwell	NOUN
admet-275	91	3	inserts	insert	NOUN
admet-275	91	4	were	be	AUX
admet-275	91	5	placed	place	VERB
admet-275	91	6	into	into	ADP
admet-275	91	7	a	a	DET
admet-275	91	8	multiwelltm	multiwelltm	NOUN
admet-275	91	9	feeder	feeder	NOUN
admet-275	91	10	tray	tray	NOUN
admet-275	91	11	,	,	PUNCT
admet-275	91	12	covered	cover	VERB
admet-275	91	13	with	with	ADP
admet-275	91	14	breatheasier	breatheasier	ADJ
admet-275	91	15	cell	cell	NOUN
admet-275	91	16	culture	culture	NOUN
admet-275	91	17	foil	foil	NOUN
admet-275	91	18	,	,	PUNCT
admet-275	91	19	and	and	CCONJ
admet-275	91	20	incubated	incubate	VERB
admet-275	91	21	for	for	ADP
admet-275	91	22	22	22	NUM
admet-275	91	23	-	-	SYM
admet-275	91	24	24	24	NUM
admet-275	91	25	h	h	NOUN
admet-275	91	26	at	at	ADP
admet-275	91	27	37	37	NUM
admet-275	91	28	°	°	NOUN
admet-275	91	29	c	c	NOUN
admet-275	91	30	,	,	PUNCT
admet-275	91	31	5	5	NUM
admet-275	91	32	%	%	NOUN
admet-275	91	33	co2	co2	NOUN
admet-275	91	34	and	and	CCONJ
admet-275	91	35	100	100	NUM
admet-275	91	36	%	%	NOUN
admet-275	91	37	humidity	humidity	NOUN
admet-275	91	38	;	;	PUNCT
admet-275	91	39	the	the	DET
admet-275	91	40	medium	medium	NOUN
admet-275	91	41	was	be	AUX
admet-275	91	42	aspirated	aspirate	VERB
admet-275	91	43	from	from	ADP
admet-275	91	44	both	both	CCONJ
admet-275	91	45	apical	apical	ADJ
admet-275	91	46	and	and	CCONJ
admet-275	91	47	basolateral	basolateral	ADJ
admet-275	91	48	side	side	NOUN
admet-275	91	49	and	and	CCONJ
admet-275	91	50	replaced	replace	VERB
admet-275	91	51	with	with	ADP
admet-275	91	52	entero	entero	PROPN
admet-275	91	53	-	-	PUNCT
admet-275	91	54	stimtm	stimtm	NOUN
admet-275	91	55	supplemented	supplement	VERB
admet-275	91	56	with	with	ADP
admet-275	91	57	0.1	0.1	NUM
admet-275	91	58	%	%	NOUN
admet-275	91	59	lyophilized	lyophilized	ADJ
admet-275	91	60	powder	powder	NOUN
admet-275	91	61	mito+	mito+	NOUN
admet-275	91	62	serum	serum	NOUN
admet-275	91	63	extender	extender	NOUN
admet-275	91	64	and	and	CCONJ
admet-275	91	65	1	1	NUM
admet-275	91	66	%	%	NOUN
admet-275	91	67	p	p	X
admet-275	91	68	/	/	SYM
admet-275	91	69	s	s	X
admet-275	91	70	(	(	PUNCT
admet-275	91	71	entero	entero	X
admet-275	91	72	-	-	PUNCT
admet-275	91	73	stimtm	stimtm	NOUN
admet-275	91	74	supplemented	supplement	VERB
admet-275	91	75	)	)	PUNCT
admet-275	91	76	for	for	ADP
admet-275	91	77	44	44	NUM
admet-275	91	78	-	-	SYM
admet-275	91	79	48	48	NUM
admet-275	91	80	hours	hour	NOUN
admet-275	91	81	enabling	enable	VERB
admet-275	91	82	cells	cell	NOUN
admet-275	91	83	to	to	PART
admet-275	91	84	differentiate	differentiate	VERB
admet-275	91	85	.	.	PUNCT
admet-275	92	1	for	for	ADP
admet-275	92	2	the	the	DET
admet-275	92	3	permeation	permeation	NOUN
admet-275	92	4	the	the	DET
admet-275	92	5	multiwelltm	multiwelltm	NOUN
admet-275	92	6	feeder	feeder	NOUN
admet-275	92	7	tray	tray	NOUN
admet-275	92	8	was	be	AUX
admet-275	92	9	replaced	replace	VERB
admet-275	92	10	for	for	ADP
admet-275	92	11	a	a	DET
admet-275	92	12	falcon	falcon	NOUN
admet-275	92	13	®	®	NOUN
admet-275	92	14	24	24	NUM
admet-275	92	15	-	-	PUNCT
admet-275	92	16	well	well	NOUN
admet-275	92	17	plate	plate	NOUN
admet-275	92	18	at	at	ADP
admet-275	92	19	37	37	NUM
admet-275	92	20	°	°	NOUN
admet-275	92	21	c	c	NOUN
admet-275	92	22	,	,	PUNCT
admet-275	92	23	5	5	NUM
admet-275	92	24	%	%	NOUN
admet-275	92	25	co2	co2	NOUN
admet-275	92	26	and	and	CCONJ
admet-275	92	27	100	100	NUM
admet-275	92	28	%	%	NOUN
admet-275	92	29	humidity	humidity	NOUN
admet-275	92	30	.	.	PUNCT
admet-275	93	1	the	the	DET
admet-275	93	2	medium	medium	NOUN
admet-275	93	3	at	at	ADP
admet-275	93	4	the	the	DET
admet-275	93	5	apical	apical	ADJ
admet-275	93	6	site	site	NOUN
admet-275	93	7	was	be	AUX
admet-275	93	8	replaced	replace	VERB
admet-275	93	9	with	with	ADP
admet-275	93	10	300	300	NUM
admet-275	93	11	l	l	PROPN
admet-275	93	12	hank	hank	PROPN
admet-275	93	13	’s	’s	PART
admet-275	93	14	buffered	buffer	VERB
admet-275	93	15	salt	salt	NOUN
admet-275	93	16	solution	solution	NOUN
admet-275	93	17	(	(	PUNCT
admet-275	93	18	hbss	hbss	NOUN
admet-275	93	19	)	)	PUNCT
admet-275	93	20	,	,	PUNCT
admet-275	93	21	100	100	NUM
admet-275	93	22	m	m	PROPN
admet-275	93	23	cimetidine	cimetidine	NOUN
admet-275	93	24	,	,	PUNCT
admet-275	93	25	desipramine	desipramine	NOUN
admet-275	93	26	or	or	CCONJ
admet-275	93	27	10	10	NUM
admet-275	93	28	m	m	PROPN
admet-275	93	29	verapamil	verapamil	NOUN
admet-275	93	30	(	(	PUNCT
admet-275	93	31	apical	apical	ADJ
admet-275	93	32	side	side	NOUN
admet-275	93	33	)	)	PUNCT
admet-275	93	34	and	and	CCONJ
admet-275	93	35	1	1	NUM
admet-275	93	36	ml	ml	NOUN
admet-275	93	37	hbss	hbss	NOUN
admet-275	93	38	(	(	PUNCT
admet-275	93	39	basolateral	basolateral	ADJ
admet-275	93	40	side	side	NOUN
admet-275	93	41	)	)	PUNCT
admet-275	93	42	.	.	PUNCT
admet-275	94	1	trans	trans	PROPN
admet-275	94	2	epithelial	epithelial	ADJ
admet-275	94	3	electral	electral	ADJ
admet-275	94	4	resistance	resistance	NOUN
admet-275	94	5	(	(	PUNCT
admet-275	94	6	teer	teer	PROPN
admet-275	94	7	)	)	PUNCT
admet-275	94	8	was	be	AUX
admet-275	94	9	measured	measure	VERB
admet-275	94	10	using	use	VERB
admet-275	94	11	a	a	DET
admet-275	94	12	millicell	millicell	NOUN
admet-275	94	13	-	-	PUNCT
admet-275	94	14	ersvoltmeter	ersvoltmeter	NOUN
admet-275	94	15	to	to	PART
admet-275	94	16	verify	verify	VERB
admet-275	94	17	the	the	DET
admet-275	94	18	quality	quality	NOUN
admet-275	94	19	of	of	ADP
admet-275	94	20	the	the	DET
admet-275	94	21	caco-2	caco-2	NUM
admet-275	94	22	cell	cell	NOUN
admet-275	94	23	monolayers	monolayer	NOUN
admet-275	94	24	.	.	PUNCT
admet-275	95	1	monolayers	monolayer	NOUN
admet-275	95	2	with	with	ADP
admet-275	95	3	teer	teer	NOUN
admet-275	95	4	values	value	NOUN
admet-275	95	5	determined	determine	VERB
admet-275	95	6	below	below	ADP
admet-275	95	7	165	165	NUM
admet-275	95	8	ω	ω	NOUN
admet-275	95	9	cm2	cm2	PROPN
admet-275	95	10	were	be	AUX
admet-275	95	11	discarded	discard	VERB
admet-275	95	12	[	[	PUNCT
admet-275	95	13	35	35	NUM
admet-275	95	14	]	]	PUNCT
admet-275	95	15	.	.	PUNCT
admet-275	96	1	next	next	ADV
admet-275	96	2	,	,	PUNCT
admet-275	96	3	the	the	DET
admet-275	96	4	hbss	hbss	NOUN
admet-275	96	5	and	and	CCONJ
admet-275	96	6	hoct	hoct	NOUN
admet-275	96	7	inhibitor	inhibitor	NOUN
admet-275	96	8	solution	solution	NOUN
admet-275	96	9	were	be	AUX
admet-275	96	10	replaced	replace	VERB
admet-275	96	11	for	for	ADP
admet-275	96	12	300	300	NUM
admet-275	96	13	l	l	NOUN
admet-275	96	14	of	of	ADP
admet-275	96	15	20	20	NUM
admet-275	96	16	m	m	PROPN
admet-275	96	17	erlotinib	erlotinib	NOUN
admet-275	96	18	,	,	PUNCT
admet-275	96	19	gefitinib	gefitinib	NOUN
admet-275	96	20	,	,	PUNCT
admet-275	96	21	sorafenib	sorafenib	NOUN
admet-275	96	22	,	,	PUNCT
admet-275	96	23	sunitinib	sunitinib	NOUN
admet-275	96	24	,	,	PUNCT
admet-275	96	25	dasatinib	dasatinib	NOUN
admet-275	96	26	or	or	CCONJ
admet-275	96	27	crizotinib	crizotinib	VERB
admet-275	96	28	alone	alone	ADV
admet-275	96	29	or	or	CCONJ
admet-275	96	30	in	in	ADP
admet-275	96	31	combination	combination	NOUN
admet-275	96	32	with	with	ADP
admet-275	96	33	100	100	NUM
admet-275	96	34	m	m	PROPN
admet-275	96	35	cimetidine	cimetidine	NOUN
admet-275	96	36	,	,	PUNCT
admet-275	96	37	desipramine	desipramine	NOUN
admet-275	96	38	or	or	CCONJ
admet-275	96	39	10	10	NUM
admet-275	96	40	m	m	PROPN
admet-275	96	41	verapamil	verapamil	NOUN
admet-275	96	42	(	(	PUNCT
admet-275	96	43	apical	apical	ADJ
admet-275	96	44	side	side	NOUN
admet-275	96	45	)	)	PUNCT
admet-275	96	46	and	and	CCONJ
admet-275	96	47	1	1	NUM
admet-275	96	48	ml	ml	NOUN
admet-275	96	49	hbss	hbss	NOUN
admet-275	96	50	+	+	CCONJ
admet-275	96	51	5	5	NUM
admet-275	96	52	%	%	NOUN
admet-275	96	53	bsa	bsa	PROPN
admet-275	96	54	(	(	PUNCT
admet-275	96	55	basolateral	basolateral	ADJ
admet-275	96	56	side	side	NOUN
admet-275	96	57	)	)	PUNCT
admet-275	96	58	.	.	PUNCT
admet-275	97	1	immediately	immediately	ADV
admet-275	97	2	after	after	SCONJ
admet-275	97	3	the	the	DET
admet-275	97	4	addition	addition	NOUN
admet-275	97	5	of	of	ADP
admet-275	97	6	the	the	DET
admet-275	97	7	solutions	solution	NOUN
admet-275	97	8	samples	sample	NOUN
admet-275	97	9	of	of	ADP
admet-275	97	10	20	20	NUM
admet-275	97	11	l	l	NOUN
admet-275	97	12	were	be	AUX
admet-275	97	13	taken	take	VERB
admet-275	97	14	from	from	ADP
admet-275	97	15	the	the	DET
admet-275	97	16	apical	apical	ADJ
admet-275	97	17	side	side	NOUN
admet-275	97	18	(	(	PUNCT
admet-275	97	19	volume	volume	NOUN
admet-275	97	20	was	be	AUX
admet-275	97	21	not	not	PART
admet-275	97	22	replaced	replace	VERB
admet-275	97	23	)	)	PUNCT
admet-275	97	24	.	.	PUNCT
admet-275	98	1	the	the	DET
admet-275	98	2	plate	plate	NOUN
admet-275	98	3	was	be	AUX
admet-275	98	4	incubated	incubate	VERB
admet-275	98	5	under	under	ADP
admet-275	98	6	gently	gently	ADV
admet-275	98	7	shaking	shake	VERB
admet-275	98	8	(	(	PUNCT
admet-275	98	9	100	100	NUM
admet-275	98	10	rpm	rpm	NOUN
admet-275	98	11	)	)	PUNCT
admet-275	98	12	at	at	ADP
admet-275	98	13	37	37	NUM
admet-275	98	14	°	°	NOUN
admet-275	98	15	c	c	NOUN
admet-275	98	16	,	,	PUNCT
admet-275	98	17	5	5	NUM
admet-275	98	18	%	%	NOUN
admet-275	98	19	co2	co2	NOUN
admet-275	98	20	and	and	CCONJ
admet-275	98	21	100	100	NUM
admet-275	98	22	%	%	NOUN
admet-275	98	23	humidity	humidity	NOUN
admet-275	98	24	.	.	PUNCT
admet-275	99	1	samples	sample	NOUN
admet-275	99	2	of	of	ADP
admet-275	99	3	50	50	NUM
admet-275	99	4	l	l	NOUN
admet-275	99	5	were	be	AUX
admet-275	99	6	taken	take	VERB
admet-275	99	7	after	after	ADP
admet-275	99	8	15	15	NUM
admet-275	99	9	,	,	PUNCT
admet-275	99	10	30	30	NUM
admet-275	99	11	,	,	PUNCT
admet-275	99	12	60	60	NUM
admet-275	99	13	,	,	PUNCT
admet-275	99	14	90	90	NUM
admet-275	99	15	,	,	PUNCT
admet-275	99	16	120	120	NUM
admet-275	99	17	and	and	CCONJ
admet-275	99	18	180	180	NUM
admet-275	99	19	min	min	NOUN
admet-275	99	20	from	from	ADP
admet-275	99	21	the	the	DET
admet-275	99	22	basolateral	basolateral	ADJ
admet-275	99	23	side	side	NOUN
admet-275	99	24	(	(	PUNCT
admet-275	99	25	volume	volume	NOUN
admet-275	99	26	was	be	AUX
admet-275	99	27	replaced	replace	VERB
admet-275	99	28	by	by	ADP
admet-275	99	29	hbss	hbss	NOUN
admet-275	99	30	+	+	CCONJ
admet-275	99	31	5	5	NUM
admet-275	99	32	%	%	NOUN
admet-275	99	33	bsa	bsa	NOUN
admet-275	99	34	)	)	PUNCT
admet-275	99	35	.	.	PUNCT
admet-275	100	1	finally	finally	ADV
admet-275	100	2	,	,	PUNCT
admet-275	100	3	samples	sample	NOUN
admet-275	100	4	of	of	ADP
admet-275	100	5	20	20	NUM
admet-275	100	6	l	l	NOUN
admet-275	100	7	were	be	AUX
admet-275	100	8	taken	take	VERB
admet-275	100	9	from	from	ADP
admet-275	100	10	the	the	DET
admet-275	100	11	apical	apical	ADJ
admet-275	100	12	side	side	NOUN
admet-275	100	13	at	at	ADP
admet-275	100	14	180	180	NUM
admet-275	100	15	minutes	minute	NOUN
admet-275	100	16	and	and	CCONJ
admet-275	100	17	the	the	DET
admet-275	100	18	cells	cell	NOUN
admet-275	100	19	were	be	AUX
admet-275	100	20	harvested	harvest	VERB
admet-275	100	21	from	from	ADP
admet-275	100	22	the	the	DET
admet-275	100	23	filter	filter	NOUN
admet-275	100	24	inserts	insert	NOUN
admet-275	100	25	,	,	PUNCT
admet-275	100	26	by	by	ADP
admet-275	100	27	washing	wash	VERB
admet-275	100	28	twice	twice	ADV
admet-275	100	29	with	with	ADP
admet-275	100	30	pbs	pbs	PROPN
admet-275	100	31	(	(	PUNCT
admet-275	100	32	room	room	NOUN
admet-275	100	33	temperature	temperature	NOUN
admet-275	100	34	)	)	PUNCT
admet-275	100	35	on	on	ADP
admet-275	100	36	both	both	CCONJ
admet-275	100	37	apical	apical	ADJ
admet-275	100	38	(	(	PUNCT
admet-275	100	39	400	400	NUM
admet-275	100	40	l	l	NOUN
admet-275	100	41	)	)	PUNCT
admet-275	100	42	and	and	CCONJ
admet-275	100	43	basolateral	basolateral	ADJ
admet-275	100	44	side	side	NOUN
admet-275	100	45	(	(	PUNCT
admet-275	100	46	1	1	NUM
admet-275	100	47	ml	ml	NOUN
admet-275	100	48	)	)	PUNCT
admet-275	100	49	.	.	PUNCT
admet-275	101	1	pbs	pbs	PROPN
admet-275	101	2	was	be	AUX
admet-275	101	3	replaced	replace	VERB
admet-275	101	4	by	by	ADP
admet-275	101	5	50	50	NUM
admet-275	101	6	l	l	PROPN
admet-275	101	7	of	of	ADP
admet-275	101	8	trypsin	trypsin	PROPN
admet-275	101	9	/	/	SYM
admet-275	101	10	edta	edta	NOUN
admet-275	101	11	to	to	PART
admet-275	101	12	allow	allow	VERB
admet-275	101	13	cells	cell	NOUN
admet-275	101	14	to	to	PART
admet-275	101	15	detach	detach	VERB
admet-275	101	16	;	;	PUNCT
admet-275	101	17	then	then	ADV
admet-275	101	18	cells	cell	NOUN
admet-275	101	19	were	be	AUX
admet-275	101	20	re	re	VERB
admet-275	101	21	-	-	VERB
admet-275	101	22	suspended	suspend	VERB
admet-275	101	23	with	with	ADP
admet-275	101	24	150	150	NUM
admet-275	101	25	l	l	PROPN
admet-275	101	26	pbs	pbs	PROPN
admet-275	101	27	,	,	PUNCT
admet-275	101	28	transferred	transfer	VERB
admet-275	101	29	into	into	ADP
admet-275	101	30	eppendorf	eppendorf	PROPN
admet-275	101	31	tubes	tube	NOUN
admet-275	101	32	and	and	CCONJ
admet-275	101	33	spun	spin	VERB
admet-275	101	34	down	down	ADP
admet-275	101	35	for	for	ADP
admet-275	101	36	5	5	NUM
admet-275	101	37	minutes	minute	NOUN
admet-275	101	38	at	at	ADP
admet-275	101	39	10621	10621	NUM
admet-275	101	40	g	g	NOUN
admet-275	101	41	at	at	ADP
admet-275	101	42	4	4	NUM
admet-275	101	43	°	°	NOUN
admet-275	101	44	c	c	NOUN
admet-275	101	45	.	.	PUNCT
admet-275	102	1	the	the	DET
admet-275	102	2	supernatant	supernatant	NOUN
admet-275	102	3	was	be	AUX
admet-275	102	4	aspirated	aspirate	VERB
admet-275	102	5	and	and	CCONJ
admet-275	102	6	the	the	DET
admet-275	102	7	pellet	pellet	NOUN
admet-275	102	8	was	be	AUX
admet-275	102	9	snap	snap	ADJ
admet-275	102	10	frozen	freeze	VERB
admet-275	102	11	in	in	ADP
admet-275	102	12	liquid	liquid	ADJ
admet-275	102	13	nitrogen	nitrogen	NOUN
admet-275	102	14	and	and	CCONJ
admet-275	102	15	stored	store	VERB
admet-275	102	16	at	at	ADP
admet-275	102	17	-80	-80	NOUN
admet-275	102	18	°	°	ADP
admet-275	102	19	c	c	NOUN
admet-275	102	20	until	until	ADP
admet-275	102	21	analysis	analysis	NOUN
admet-275	102	22	by	by	ADP
admet-275	102	23	lc	lc	PROPN
admet-275	102	24	-	-	PUNCT
admet-275	102	25	ms	ms	PROPN
admet-275	102	26	/	/	SYM
admet-275	102	27	ms	ms	PROPN
admet-275	102	28	.	.	PROPN
admet-275	103	1	the	the	DET
admet-275	103	2	protein	protein	NOUN
admet-275	103	3	content	content	NOUN
admet-275	103	4	was	be	AUX
admet-275	103	5	determined	determine	VERB
admet-275	103	6	using	use	VERB
admet-275	103	7	the	the	DET
admet-275	103	8	bio	bio	NOUN
admet-275	103	9	-	-	ADJ
admet-275	103	10	rad	rad	ADJ
admet-275	103	11	protein	protein	NOUN
admet-275	103	12	assay	assay	VERB
admet-275	103	13	.	.	PUNCT
admet-275	104	1	data	datum	NOUN
admet-275	104	2	analysis	analysis	NOUN
admet-275	104	3	by	by	ADP
admet-275	104	4	lc	lc	PROPN
admet-275	104	5	-	-	PUNCT
admet-275	104	6	ms	ms	PROPN
admet-275	104	7	/	/	SYM
admet-275	104	8	ms	ms	NOUN
admet-275	104	9	all	all	DET
admet-275	104	10	samples	sample	NOUN
admet-275	104	11	of	of	ADP
admet-275	104	12	the	the	DET
admet-275	104	13	accumulation	accumulation	NOUN
admet-275	104	14	and	and	CCONJ
admet-275	104	15	transwell	transwell	NOUN
admet-275	104	16	studies	study	NOUN
admet-275	104	17	were	be	AUX
admet-275	104	18	measured	measure	VERB
admet-275	104	19	using	use	VERB
admet-275	104	20	liquid	liquid	ADJ
admet-275	104	21	chromatography	chromatography	NOUN
admet-275	104	22	coupled	couple	VERB
admet-275	104	23	to	to	PART
admet-275	104	24	mass	mass	VERB
admet-275	104	25	spectrometry	spectrometry	NOUN
admet-275	104	26	to	to	PART
admet-275	104	27	determine	determine	VERB
admet-275	104	28	the	the	DET
admet-275	104	29	amount	amount	NOUN
admet-275	104	30	of	of	ADP
admet-275	104	31	drug	drug	NOUN
admet-275	104	32	(	(	PUNCT
admet-275	104	33	tki	tki	NOUN
admet-275	104	34	)	)	PUNCT
admet-275	104	35	present	present	NOUN
admet-275	105	1	[	[	X
admet-275	105	2	34	34	NUM
admet-275	105	3	]	]	PUNCT
admet-275	105	4	.	.	PUNCT
admet-275	106	1	sample	sample	NOUN
admet-275	106	2	pellets	pellet	NOUN
admet-275	106	3	were	be	AUX
admet-275	106	4	resuspended	resuspend	VERB
admet-275	106	5	in	in	ADP
admet-275	106	6	200	200	NUM
admet-275	106	7	l	l	NOUN
admet-275	106	8	of	of	ADP
admet-275	106	9	ice	ice	NOUN
admet-275	106	10	cold	cold	ADJ
admet-275	106	11	water	water	NOUN
admet-275	106	12	and	and	CCONJ
admet-275	106	13	homogenized	homogenize	VERB
admet-275	106	14	by	by	ADP
admet-275	106	15	aspiration	aspiration	NOUN
admet-275	106	16	via	via	ADP
admet-275	106	17	a	a	DET
admet-275	106	18	pipette	pipette	NOUN
admet-275	106	19	tip	tip	NOUN
admet-275	106	20	.	.	PUNCT
admet-275	107	1	cell	cell	NOUN
admet-275	107	2	pellets	pellet	NOUN
admet-275	107	3	of	of	ADP
admet-275	107	4	the	the	DET
admet-275	107	5	caco-2	caco-2	NUM
admet-275	107	6	monolayer	monolayer	NOUN
admet-275	107	7	were	be	AUX
admet-275	107	8	also	also	ADV
admet-275	107	9	transferred	transfer	VERB
admet-275	107	10	into	into	ADP
admet-275	107	11	qiagen	qiagen	NOUN
admet-275	107	12	shredder	shredder	NOUN
admet-275	107	13	tubes	tube	NOUN
admet-275	107	14	(	(	PUNCT
admet-275	107	15	containing	contain	VERB
admet-275	107	16	qia	qia	PROPN
admet-275	107	17	shredder	shredder	PROPN
admet-275	107	18	mini	mini	NOUN
admet-275	107	19	spin	spin	NOUN
admet-275	107	20	columns	column	NOUN
admet-275	107	21	)	)	PUNCT
admet-275	107	22	and	and	CCONJ
admet-275	107	23	spun	spin	VERB
admet-275	107	24	down	down	ADP
admet-275	107	25	at	at	ADP
admet-275	107	26	15800	15800	NUM
admet-275	107	27	g	g	NOUN
admet-275	107	28	for	for	ADP
admet-275	107	29	2	2	NUM
admet-275	107	30	min	min	NOUN
admet-275	107	31	to	to	PART
admet-275	107	32	prepare	prepare	VERB
admet-275	107	33	a	a	DET
admet-275	107	34	homogeneous	homogeneous	ADJ
admet-275	107	35	sample	sample	NOUN
admet-275	107	36	.	.	PUNCT
admet-275	108	1	subsequently	subsequently	ADV
admet-275	108	2	,	,	PUNCT
admet-275	108	3	20	20	NUM
admet-275	108	4	l	l	NOUN
admet-275	108	5	of	of	ADP
admet-275	108	6	each	each	DET
admet-275	108	7	sample	sample	NOUN
admet-275	108	8	was	be	AUX
admet-275	108	9	transferred	transfer	VERB
admet-275	108	10	to	to	ADP
admet-275	108	11	96	96	NUM
admet-275	108	12	-	-	PUNCT
admet-275	108	13	well	well	NOUN
admet-275	108	14	plates	plate	NOUN
admet-275	108	15	and	and	CCONJ
admet-275	108	16	80	80	NUM
admet-275	108	17	l	l	NOUN
admet-275	108	18	of	of	ADP
admet-275	108	19	ice	ice	NOUN
admet-275	108	20	cold	cold	ADJ
admet-275	108	21	acetonitrile	acetonitrile	NOUN
admet-275	108	22	added	add	VERB
admet-275	108	23	.	.	PUNCT
admet-275	109	1	each	each	DET
admet-275	109	2	plate	plate	NOUN
admet-275	109	3	was	be	AUX
admet-275	109	4	covered	cover	VERB
admet-275	109	5	with	with	ADP
admet-275	109	6	a	a	DET
admet-275	109	7	plastic	plastic	ADJ
admet-275	109	8	foil	foil	NOUN
admet-275	109	9	,	,	PUNCT
admet-275	109	10	sonicated	sonicate	VERB
admet-275	109	11	for	for	ADP
admet-275	109	12	30	30	NUM
admet-275	109	13	seconds	second	NOUN
admet-275	109	14	and	and	CCONJ
admet-275	109	15	centrifuged	centrifuge	VERB
admet-275	109	16	at	at	ADP
admet-275	109	17	1500	1500	NUM
admet-275	109	18	g	g	NOUN
admet-275	109	19	at	at	ADP
admet-275	109	20	4	4	NUM
admet-275	109	21	°	°	ADP
admet-275	109	22	c	c	NOUN
admet-275	109	23	for	for	ADP
admet-275	109	24	10	10	NUM
admet-275	109	25	min	min	NOUN
admet-275	109	26	.	.	PROPN
admet-275	109	27	next	next	ADJ
admet-275	109	28	,	,	PUNCT
admet-275	109	29	50	50	NUM
admet-275	109	30	l	l	NOUN
admet-275	109	31	of	of	ADP
admet-275	109	32	each	each	DET
admet-275	109	33	sample	sample	NOUN
admet-275	109	34	was	be	AUX
admet-275	109	35	transferred	transfer	VERB
admet-275	109	36	to	to	PART
admet-275	109	37	clean	clean	VERB
admet-275	109	38	96	96	NUM
admet-275	109	39	-	-	PUNCT
admet-275	109	40	well	well	NOUN
admet-275	109	41	plates	plate	NOUN
admet-275	109	42	and	and	CCONJ
admet-275	109	43	covered	cover	VERB
admet-275	109	44	with	with	ADP
admet-275	109	45	an	an	DET
admet-275	109	46	nunc	nunc	NOUN
admet-275	109	47	well	well	NOUN
admet-275	109	48	plate	plate	NOUN
admet-275	109	49	seal	seal	NOUN
admet-275	109	50	.	.	PUNCT
admet-275	110	1	lastly	lastly	ADV
admet-275	110	2	,	,	PUNCT
admet-275	110	3	1	1	NUM
admet-275	110	4	l	l	PROPN
admet-275	110	5	of	of	ADP
admet-275	110	6	each	each	DET
admet-275	110	7	sample	sample	NOUN
admet-275	110	8	was	be	AUX
admet-275	110	9	injected	inject	VERB
admet-275	110	10	into	into	ADP
admet-275	110	11	the	the	DET
admet-275	110	12	lc	lc	PROPN
admet-275	110	13	-	-	PUNCT
admet-275	110	14	ms	ms	PROPN
admet-275	110	15	/	/	SYM
admet-275	110	16	ms	ms	PROPN
admet-275	110	17	.	.	PROPN
admet-275	110	18	compounds	compound	NOUN
admet-275	110	19	were	be	AUX
admet-275	110	20	separated	separate	VERB
admet-275	110	21	on	on	ADP
admet-275	110	22	a	a	DET
admet-275	110	23	phenomenex	phenomenex	ADV
admet-275	110	24	prodigy	prodigy	NOUN
admet-275	110	25	ods3	ods3	PROPN
admet-275	110	26	,	,	PUNCT
admet-275	110	27	100x2	100x2	NUM
admet-275	110	28	mm	mm	NOUN
admet-275	110	29	,	,	PUNCT
admet-275	110	30	3	3	NUM
admet-275	110	31	m	m	PROPN
admet-275	110	32	column	column	NOUN
admet-275	110	33	using	use	VERB
admet-275	110	34	a	a	DET
admet-275	110	35	mobile	mobile	ADJ
admet-275	110	36	phase	phase	NOUN
admet-275	110	37	containing	contain	VERB
admet-275	110	38	0.578	0.578	NUM
admet-275	110	39	g	g	PROPN
admet-275	110	40	ammonium	ammonium	NOUN
admet-275	110	41	acetate	acetate	NOUN
admet-275	110	42	,	,	PUNCT
admet-275	110	43	375	375	NUM
admet-275	110	44	ml	ml	NOUN
admet-275	110	45	milliq	milliq	NOUN
admet-275	110	46	,	,	PUNCT
admet-275	110	47	125	125	NUM
admet-275	110	48	ml	ml	NOUN
admet-275	110	49	methanol	methanol	NOUN
admet-275	110	50	,	,	PUNCT
admet-275	110	51	0.1	0.1	NUM
admet-275	110	52	%	%	NOUN
admet-275	110	53	isopropanol	isopropanol	NOUN
admet-275	110	54	and	and	CCONJ
admet-275	110	55	1000	1000	NUM
admet-275	110	56	ml	ml	NOUN
admet-275	110	57	acetonitrile	acetonitrile	NOUN
admet-275	110	58	with	with	ADP
admet-275	110	59	a	a	DET
admet-275	110	60	ph	ph	NOUN
admet-275	110	61	of	of	ADP
admet-275	110	62	7.8	7.8	NUM
admet-275	110	63	at	at	ADP
admet-275	110	64	500	500	NUM
admet-275	110	65	l	l	PROPN
admet-275	110	66	/	/	SYM
admet-275	110	67	min	min	NOUN
admet-275	110	68	.	.	NOUN
admet-275	110	69	final	final	ADJ
admet-275	110	70	results	result	NOUN
admet-275	110	71	of	of	ADP
admet-275	110	72	the	the	DET
admet-275	110	73	lc	lc	PROPN
admet-275	110	74	-	-	PUNCT
admet-275	110	75	ms	ms	PROPN
admet-275	110	76	/	/	SYM
admet-275	110	77	ms	ms	NOUN
admet-275	110	78	(	(	PUNCT
admet-275	110	79	in	in	ADP
admet-275	110	80	ng	ng	PROPN
admet-275	110	81	/	/	SYM
admet-275	110	82	ml	ml	NOUN
admet-275	110	83	tki	tki	NOUN
admet-275	110	84	)	)	PUNCT
admet-275	110	85	were	be	AUX
admet-275	110	86	expressed	express	VERB
admet-275	110	87	in	in	ADP
admet-275	110	88	pmol	pmol	PROPN
admet-275	110	89	(	(	PUNCT
admet-275	110	90	transwell	transwell	NOUN
admet-275	110	91	)	)	PUNCT
admet-275	110	92	or	or	CCONJ
admet-275	110	93	combined	combine	VERB
admet-275	110	94	with	with	ADP
admet-275	110	95	the	the	DET
admet-275	110	96	results	result	NOUN
admet-275	110	97	of	of	ADP
admet-275	110	98	the	the	DET
admet-275	110	99	protein	protein	NOUN
admet-275	110	100	content	content	NOUN
admet-275	110	101	determination	determination	NOUN
admet-275	110	102	(	(	PUNCT
admet-275	110	103	mg	mg	NOUN
admet-275	110	104	/	/	SYM
admet-275	110	105	ml	ml	NOUN
admet-275	110	106	protein	protein	NOUN
admet-275	110	107	)	)	PUNCT
admet-275	110	108	,	,	PUNCT
admet-275	110	109	obtaining	obtain	VERB
admet-275	110	110	data	datum	NOUN
admet-275	110	111	expressed	express	VERB
admet-275	110	112	in	in	ADP
admet-275	110	113	ng	ng	PROPN
admet-275	110	114	drug	drug	NOUN
admet-275	110	115	per	per	ADP
admet-275	110	116	mg	mg	PROPN
admet-275	110	117	protein	protein	NOUN
admet-275	110	118	.	.	PUNCT
admet-275	111	1	admet	admet	PROPN
admet-275	111	2	&	&	CCONJ
admet-275	111	3	dmpk	dmpk	PROPN
admet-275	111	4	4(1	4(1	NOUN
admet-275	111	5	)	)	PUNCT
admet-275	111	6	(	(	PUNCT
admet-275	111	7	2016	2016	NUM
admet-275	111	8	)	)	PUNCT
admet-275	111	9	23	23	NUM
admet-275	111	10	-	-	SYM
admet-275	111	11	34	34	NUM
admet-275	111	12	transport	transport	NOUN
admet-275	111	13	mechanism	mechanism	NOUN
admet-275	111	14	of	of	ADP
admet-275	111	15	tk	tk	PROPN
admet-275	111	16	inhibitors	inhibitor	NOUN
admet-275	111	17	doi	doi	NOUN
admet-275	111	18	:	:	PUNCT
admet-275	111	19	10.5599	10.5599	NUM
admet-275	111	20	/	/	SYM
admet-275	111	21	admet.4.1.275	admet.4.1.275	PROPN
admet-275	111	22	27	27	NUM
admet-275	111	23	calculations	calculation	NOUN
admet-275	111	24	apparent	apparent	ADJ
admet-275	111	25	permeability	permeability	NOUN
admet-275	111	26	coefficients	coefficient	NOUN
admet-275	111	27	were	be	AUX
admet-275	111	28	estimated	estimate	VERB
admet-275	111	29	by	by	ADP
admet-275	111	30	the	the	DET
admet-275	111	31	following	follow	VERB
admet-275	111	32	equation	equation	NOUN
admet-275	111	33	:	:	PUNCT
admet-275	111	34	app	app	PROPN
admet-275	111	35	q	q	PROPN
admet-275	111	36	v	v	PROPN
admet-275	111	37	p	p	PROPN
admet-275	111	38	t	t	PROPN
admet-275	111	39	c	c	PROPN
admet-275	111	40	a0	a0	PROPN
admet-275	111	41			NOUN
admet-275	111	42			NOUN
admet-275	111	43			X
admet-275	111	44	where	where	SCONJ
admet-275	111	45	papp	papp	NOUN
admet-275	111	46	is	be	AUX
admet-275	111	47	the	the	DET
admet-275	111	48	apparent	apparent	ADJ
admet-275	111	49	permeability	permeability	NOUN
admet-275	111	50	coefficient	coefficient	NOUN
admet-275	111	51	(	(	PUNCT
admet-275	111	52	cm	cm	NOUN
admet-275	111	53	/	/	SYM
admet-275	111	54	sec	sec	PROPN
admet-275	111	55	)	)	PUNCT
admet-275	111	56	,	,	PUNCT
admet-275	111	57	q/t	q/t	PROPN
admet-275	111	58	is	be	AUX
admet-275	111	59	the	the	DET
admet-275	111	60	rate	rate	NOUN
admet-275	111	61	of	of	ADP
admet-275	111	62	accumulative	accumulative	ADJ
admet-275	111	63	mass	mass	NOUN
admet-275	111	64	transport	transport	NOUN
admet-275	111	65	in	in	ADP
admet-275	111	66	the	the	DET
admet-275	111	67	receiver	receiver	ADJ
admet-275	111	68	chamber	chamber	NOUN
admet-275	111	69	over	over	ADP
admet-275	111	70	time	time	NOUN
admet-275	111	71	(	(	PUNCT
admet-275	111	72	m	m	PROPN
admet-275	111	73	/	/	SYM
admet-275	111	74	sec	sec	PROPN
admet-275	111	75	)	)	PUNCT
admet-275	111	76	,	,	PUNCT
admet-275	111	77	v	v	X
admet-275	111	78	is	be	AUX
admet-275	111	79	the	the	DET
admet-275	111	80	volume	volume	NOUN
admet-275	111	81	in	in	ADP
admet-275	111	82	the	the	DET
admet-275	111	83	receiver	receiver	ADJ
admet-275	111	84	chamber	chamber	NOUN
admet-275	111	85	(	(	PUNCT
admet-275	111	86	ml	ml	PROPN
admet-275	111	87	)	)	PUNCT
admet-275	111	88	,	,	PUNCT
admet-275	111	89	c0	c0	PROPN
admet-275	111	90	is	be	AUX
admet-275	111	91	the	the	DET
admet-275	111	92	concentration	concentration	NOUN
admet-275	111	93	of	of	ADP
admet-275	111	94	tki	tki	NOUN
admet-275	111	95	in	in	ADP
admet-275	111	96	the	the	DET
admet-275	111	97	donor	donor	NOUN
admet-275	111	98	chamber	chamber	PROPN
admet-275	111	99	(	(	PUNCT
admet-275	111	100	m	m	PROPN
admet-275	111	101	)	)	PUNCT
admet-275	111	102	and	and	CCONJ
admet-275	111	103	a	a	PRON
admet-275	111	104	is	be	AUX
admet-275	111	105	the	the	DET
admet-275	111	106	diffusion	diffusion	NOUN
admet-275	111	107	area	area	NOUN
admet-275	111	108	(	(	PUNCT
admet-275	111	109	cm2	cm2	NOUN
admet-275	111	110	)	)	PUNCT
admet-275	111	111	.	.	PUNCT
admet-275	112	1	results	result	VERB
admet-275	112	2	temperature	temperature	NOUN
admet-275	112	3	dependent	dependent	ADJ
admet-275	112	4	accumulation	accumulation	NOUN
admet-275	112	5	in	in	ADP
admet-275	112	6	caco-2	caco-2	NUM
admet-275	112	7	cells	cell	NOUN
admet-275	112	8	caco-2	caco-2	NUM
admet-275	112	9	cells	cell	NOUN
admet-275	112	10	were	be	AUX
admet-275	112	11	exposed	expose	VERB
admet-275	112	12	to	to	ADP
admet-275	112	13	the	the	DET
admet-275	112	14	six	six	NUM
admet-275	112	15	different	different	ADJ
admet-275	112	16	tkis	tkis	NOUN
admet-275	112	17	under	under	ADP
admet-275	112	18	different	different	ADJ
admet-275	112	19	temperature	temperature	NOUN
admet-275	112	20	conditions	condition	NOUN
admet-275	112	21	to	to	PART
admet-275	112	22	determine	determine	VERB
admet-275	112	23	whether	whether	SCONJ
admet-275	112	24	the	the	DET
admet-275	112	25	main	main	ADJ
admet-275	112	26	transport	transport	NOUN
admet-275	112	27	was	be	AUX
admet-275	112	28	driven	drive	VERB
admet-275	112	29	by	by	ADP
admet-275	112	30	passive	passive	ADJ
admet-275	112	31	diffusion	diffusion	NOUN
admet-275	112	32	(	(	PUNCT
admet-275	112	33	4	4	NUM
admet-275	112	34	°	°	NOUN
admet-275	112	35	c	c	NOUN
admet-275	112	36	)	)	PUNCT
admet-275	112	37	or	or	CCONJ
admet-275	112	38	by	by	ADP
admet-275	112	39	active	active	ADJ
admet-275	112	40	carrier	carrier	NOUN
admet-275	112	41	transport	transport	NOUN
admet-275	112	42	(	(	PUNCT
admet-275	112	43	37	37	NUM
admet-275	112	44	°	°	NOUN
admet-275	112	45	c	c	NOUN
admet-275	112	46	)	)	PUNCT
admet-275	112	47	,	,	PUNCT
admet-275	112	48	(	(	PUNCT
admet-275	112	49	figure	figure	NOUN
admet-275	112	50	2	2	NUM
admet-275	112	51	)	)	PUNCT
admet-275	112	52	.	.	PUNCT
admet-275	113	1	the	the	DET
admet-275	113	2	2	2	NUM
admet-275	113	3	-	-	PUNCT
admet-275	113	4	hr	hr	NOUN
admet-275	113	5	time	time	NOUN
admet-275	113	6	point	point	NOUN
admet-275	113	7	is	be	AUX
admet-275	113	8	considered	consider	VERB
admet-275	113	9	to	to	PART
admet-275	113	10	be	be	AUX
admet-275	113	11	relevant	relevant	ADJ
admet-275	113	12	for	for	ADP
admet-275	113	13	initial	initial	ADJ
admet-275	113	14	uptake	uptake	NOUN
admet-275	113	15	;	;	PUNCT
admet-275	113	16	at	at	ADP
admet-275	113	17	later	later	ADJ
admet-275	113	18	time	time	NOUN
admet-275	113	19	-	-	PUNCT
admet-275	113	20	points	point	NOUN
admet-275	113	21	other	other	ADJ
admet-275	113	22	processes	process	NOUN
admet-275	113	23	(	(	PUNCT
admet-275	113	24	efflux	efflux	NOUN
admet-275	113	25	,	,	PUNCT
admet-275	113	26	metabolism	metabolism	NOUN
admet-275	113	27	,	,	PUNCT
admet-275	113	28	accumulation	accumulation	NOUN
admet-275	113	29	in	in	ADP
admet-275	113	30	cellular	cellular	ADJ
admet-275	113	31	organelles	organelle	NOUN
admet-275	113	32	)	)	PUNCT
admet-275	113	33	seem	seem	VERB
admet-275	113	34	more	more	ADV
admet-275	113	35	important	important	ADJ
admet-275	113	36	.	.	PUNCT
admet-275	114	1	after	after	ADP
admet-275	114	2	2	2	NUM
admet-275	114	3	-	-	PUNCT
admet-275	114	4	hr	hr	NOUN
admet-275	114	5	erlotinib	erlotinib	NOUN
admet-275	114	6	,	,	PUNCT
admet-275	114	7	gefitinib	gefitinib	NOUN
admet-275	114	8	and	and	CCONJ
admet-275	114	9	dasatinib	dasatinib	NOUN
admet-275	114	10	showed	show	VERB
admet-275	114	11	a	a	DET
admet-275	114	12	much	much	ADV
admet-275	114	13	higher	high	ADJ
admet-275	114	14	accumulation	accumulation	NOUN
admet-275	114	15	at	at	ADP
admet-275	114	16	37	37	NUM
admet-275	114	17	°	°	NOUN
admet-275	114	18	c	c	NOUN
admet-275	114	19	than	than	ADP
admet-275	114	20	at	at	ADP
admet-275	114	21	4	4	NUM
admet-275	114	22	°	°	NOUN
admet-275	114	23	c	c	NOUN
admet-275	114	24	,	,	PUNCT
admet-275	114	25	(	(	PUNCT
admet-275	114	26	figures	figure	NOUN
admet-275	114	27	2a	2a	NUM
admet-275	114	28	,	,	PUNCT
admet-275	114	29	b	b	NOUN
admet-275	114	30	and	and	CCONJ
admet-275	114	31	2f	2f	NUM
admet-275	114	32	,	,	PUNCT
admet-275	114	33	respectively	respectively	ADV
admet-275	114	34	)	)	PUNCT
admet-275	114	35	;	;	PUNCT
admet-275	114	36	for	for	ADP
admet-275	114	37	sunitinib	sunitinib	NOUN
admet-275	114	38	,	,	PUNCT
admet-275	114	39	crizotinib	crizotinib	VERB
admet-275	114	40	and	and	CCONJ
admet-275	114	41	sorafenib	sorafenib	NOUN
admet-275	114	42	this	this	DET
admet-275	114	43	difference	difference	NOUN
admet-275	114	44	is	be	AUX
admet-275	114	45	much	much	ADV
admet-275	114	46	less	less	ADJ
admet-275	114	47	and	and	CCONJ
admet-275	114	48	not	not	PART
admet-275	114	49	significantly	significantly	ADV
admet-275	114	50	different	different	ADJ
admet-275	114	51	(	(	PUNCT
admet-275	114	52	figures	figure	NOUN
admet-275	114	53	2c	2c	NUM
admet-275	114	54	,	,	PUNCT
admet-275	114	55	2d	2d	NOUN
admet-275	114	56	and	and	CCONJ
admet-275	114	57	2e	2e	NUM
admet-275	114	58	respectively	respectively	ADV
admet-275	114	59	)	)	PUNCT
admet-275	114	60	.	.	PUNCT
admet-275	115	1	at	at	ADP
admet-275	115	2	later	later	ADJ
admet-275	115	3	time	time	NOUN
admet-275	115	4	-	-	PUNCT
admet-275	115	5	points	point	NOUN
admet-275	115	6	the	the	DET
admet-275	115	7	pattern	pattern	NOUN
admet-275	115	8	changes	change	NOUN
admet-275	115	9	,	,	PUNCT
admet-275	115	10	erlotinib	erlotinib	VERB
admet-275	115	11	accumulation	accumulation	NOUN
admet-275	115	12	at	at	ADP
admet-275	115	13	4	4	NUM
admet-275	115	14	°	°	NOUN
admet-275	115	15	c	c	NOUN
admet-275	115	16	continued	continue	VERB
admet-275	115	17	to	to	PART
admet-275	115	18	increase	increase	VERB
admet-275	115	19	,	,	PUNCT
admet-275	115	20	but	but	CCONJ
admet-275	115	21	at	at	ADP
admet-275	115	22	37	37	NUM
admet-275	115	23	°	°	NOUN
admet-275	115	24	c	c	NOUN
admet-275	115	25	the	the	DET
admet-275	115	26	accumulation	accumulation	NOUN
admet-275	115	27	decreased	decrease	VERB
admet-275	115	28	(	(	PUNCT
admet-275	115	29	figure	figure	NOUN
admet-275	115	30	2a	2a	NUM
admet-275	115	31	)	)	PUNCT
admet-275	115	32	,	,	PUNCT
admet-275	115	33	indicating	indicate	VERB
admet-275	115	34	an	an	DET
admet-275	115	35	active	active	ADJ
admet-275	115	36	efflux	efflux	NOUN
admet-275	115	37	process	process	NOUN
admet-275	115	38	.	.	PUNCT
admet-275	116	1	sunitinib	sunitinib	NOUN
admet-275	116	2	accumulation	accumulation	NOUN
admet-275	116	3	at	at	ADP
admet-275	116	4	37	37	NUM
admet-275	116	5	°	°	NOUN
admet-275	116	6	c	c	NOUN
admet-275	116	7	continued	continue	VERB
admet-275	116	8	to	to	PART
admet-275	116	9	increase	increase	VERB
admet-275	116	10	,	,	PUNCT
admet-275	116	11	possibly	possibly	ADV
admet-275	116	12	due	due	ADP
admet-275	116	13	to	to	ADP
admet-275	116	14	a	a	DET
admet-275	116	15	lysosomal	lysosomal	ADJ
admet-275	116	16	accumulation	accumulation	NOUN
admet-275	116	17	(	(	PUNCT
admet-275	116	18	figure	figure	NOUN
admet-275	116	19	2c	2c	NUM
admet-275	116	20	)	)	PUNCT
admet-275	117	1	[	[	X
admet-275	117	2	22,39	22,39	NUM
admet-275	117	3	]	]	X
admet-275	117	4	.	.	PUNCT
admet-275	118	1	for	for	ADP
admet-275	118	2	crizotinib	crizotinib	NOUN
admet-275	118	3	,	,	PUNCT
admet-275	118	4	the	the	DET
admet-275	118	5	accumulation	accumulation	NOUN
admet-275	118	6	continued	continue	VERB
admet-275	118	7	to	to	PART
admet-275	118	8	increase	increase	VERB
admet-275	118	9	under	under	ADP
admet-275	118	10	both	both	DET
admet-275	118	11	conditions	condition	NOUN
admet-275	118	12	(	(	PUNCT
admet-275	118	13	figure	figure	NOUN
admet-275	118	14	2e	2e	NUM
admet-275	118	15	)	)	PUNCT
admet-275	118	16	,	,	PUNCT
admet-275	118	17	but	but	CCONJ
admet-275	118	18	for	for	ADP
admet-275	118	19	sorafenib	sorafenib	NOUN
admet-275	118	20	no	no	DET
admet-275	118	21	change	change	NOUN
admet-275	118	22	was	be	AUX
admet-275	118	23	observed	observe	VERB
admet-275	118	24	(	(	PUNCT
admet-275	118	25	figure	figure	NOUN
admet-275	118	26	2d	2d	NOUN
admet-275	118	27	)	)	PUNCT
admet-275	118	28	.	.	PUNCT
admet-275	119	1	transporter	transporter	VERB
admet-275	119	2	dependent	dependent	ADJ
admet-275	119	3	hoct	hoct	PROPN
admet-275	119	4	dependent	dependent	ADJ
admet-275	119	5	accumulation	accumulation	NOUN
admet-275	119	6	in	in	ADP
admet-275	119	7	caco-2	caco-2	NUM
admet-275	119	8	cells	cell	NOUN
admet-275	119	9	caco-2	caco-2	NUM
admet-275	119	10	cells	cell	NOUN
admet-275	119	11	were	be	AUX
admet-275	119	12	exposed	expose	VERB
admet-275	119	13	to	to	ADP
admet-275	119	14	several	several	ADJ
admet-275	119	15	inhibitors	inhibitor	NOUN
admet-275	119	16	of	of	ADP
admet-275	119	17	the	the	DET
admet-275	119	18	hoct	hoct	PROPN
admet-275	119	19	family	family	NOUN
admet-275	119	20	in	in	ADP
admet-275	119	21	combination	combination	NOUN
admet-275	119	22	with	with	ADP
admet-275	119	23	the	the	DET
admet-275	119	24	six	six	NUM
admet-275	119	25	tkis	tkis	NOUN
admet-275	119	26	to	to	PART
admet-275	119	27	determine	determine	VERB
admet-275	119	28	whether	whether	SCONJ
admet-275	119	29	hocts	hoct	NOUN
admet-275	119	30	are	be	AUX
admet-275	119	31	involved	involve	VERB
admet-275	119	32	in	in	ADP
admet-275	119	33	the	the	DET
admet-275	119	34	active	active	ADJ
admet-275	119	35	uptake	uptake	NOUN
admet-275	119	36	of	of	ADP
admet-275	119	37	the	the	DET
admet-275	119	38	six	six	NUM
admet-275	119	39	tkis	tkis	NOUN
admet-275	119	40	(	(	PUNCT
admet-275	119	41	figure	figure	NOUN
admet-275	119	42	3	3	NUM
admet-275	119	43	)	)	PUNCT
admet-275	119	44	.	.	PUNCT
admet-275	120	1	the	the	DET
admet-275	120	2	hoct	hoct	PROPN
admet-275	120	3	family	family	NOUN
admet-275	120	4	can	can	AUX
admet-275	120	5	be	be	AUX
admet-275	120	6	inhibited	inhibit	VERB
admet-275	120	7	by	by	ADP
admet-275	120	8	amantadine	amantadine	NOUN
admet-275	120	9	(	(	PUNCT
admet-275	120	10	hoct1&2	hoct1&2	NOUN
admet-275	120	11	)	)	PUNCT
admet-275	120	12	,	,	PUNCT
admet-275	120	13	cimetidine	cimetidine	NOUN
admet-275	120	14	(	(	PUNCT
admet-275	120	15	hoct1&2&3	hoct1&2&3	X
admet-275	120	16	)	)	PUNCT
admet-275	121	1	[	[	X
admet-275	121	2	40	40	NUM
admet-275	121	3	]	]	PUNCT
admet-275	121	4	,	,	PUNCT
admet-275	121	5	desipramine	desipramine	NOUN
admet-275	121	6	(	(	PUNCT
admet-275	121	7	hoct1&2&3	hoct1&2&3	NUM
admet-275	121	8	)	)	PUNCT
admet-275	121	9	,	,	PUNCT
admet-275	121	10	βestradiol	βestradiol	NOUN
admet-275	121	11	(	(	PUNCT
admet-275	121	12	hoct1&3	hoct1&3	ADJ
admet-275	121	13	)	)	PUNCT
admet-275	121	14	and	and	CCONJ
admet-275	121	15	verapamil	verapamil	NOUN
admet-275	121	16	(	(	PUNCT
admet-275	121	17	hoct1&p	hoct1&p	NOUN
admet-275	121	18	-	-	NOUN
admet-275	121	19	gp	gp	NOUN
admet-275	121	20	)	)	PUNCT
admet-275	122	1	[	[	X
admet-275	122	2	27,35,36	27,35,36	NUM
admet-275	122	3	]	]	X
admet-275	122	4	.	.	PUNCT
admet-275	123	1	all	all	DET
admet-275	123	2	five	five	NUM
admet-275	123	3	hoct	hoct	NOUN
admet-275	123	4	inhibitors	inhibitor	NOUN
admet-275	123	5	decreased	decrease	VERB
admet-275	123	6	gefitinib	gefitinib	NOUN
admet-275	123	7	accumulation	accumulation	NOUN
admet-275	123	8	,	,	PUNCT
admet-275	123	9	demonstrating	demonstrate	VERB
admet-275	123	10	that	that	DET
admet-275	123	11	hoct	hoct	NOUN
admet-275	123	12	is	be	AUX
admet-275	123	13	involved	involve	VERB
admet-275	123	14	in	in	ADP
admet-275	123	15	the	the	DET
admet-275	123	16	uptake	uptake	NOUN
admet-275	123	17	of	of	ADP
admet-275	123	18	gefitinib	gefitinib	NOUN
admet-275	123	19	.	.	PUNCT
admet-275	124	1	desipramine	desipramine	NOUN
admet-275	124	2	,	,	PUNCT
admet-275	124	3	cimetidine	cimetidine	NOUN
admet-275	124	4	and	and	CCONJ
admet-275	124	5	β	β	NOUN
admet-275	124	6	-	-	NOUN
admet-275	124	7	estradiol	estradiol	PROPN
admet-275	124	8	also	also	ADV
admet-275	124	9	decreased	decrease	VERB
admet-275	124	10	gefitinib	gefitinib	NOUN
admet-275	124	11	accumulation	accumulation	NOUN
admet-275	124	12	,	,	PUNCT
admet-275	124	13	indicating	indicate	VERB
admet-275	124	14	that	that	SCONJ
admet-275	124	15	hoct3	hoct3	PROPN
admet-275	124	16	is	be	AUX
admet-275	124	17	involved	involve	VERB
admet-275	124	18	in	in	ADP
admet-275	124	19	the	the	DET
admet-275	124	20	uptake	uptake	NOUN
admet-275	124	21	of	of	ADP
admet-275	124	22	gefitinib	gefitinib	NOUN
admet-275	124	23	.	.	PUNCT
admet-275	125	1	erlotinib	erlotinib	PROPN
admet-275	125	2	shows	show	VERB
admet-275	125	3	a	a	DET
admet-275	125	4	completely	completely	ADV
admet-275	125	5	different	different	ADJ
admet-275	125	6	effect	effect	NOUN
admet-275	125	7	on	on	ADP
admet-275	125	8	the	the	DET
admet-275	125	9	incubation	incubation	NOUN
admet-275	125	10	with	with	ADP
admet-275	125	11	hoct	hoct	NOUN
admet-275	125	12	inhibitors	inhibitor	NOUN
admet-275	125	13	.	.	PUNCT
admet-275	126	1	verapamil	verapamil	NOUN
admet-275	126	2	,	,	PUNCT
admet-275	126	3	desipramine	desipramine	NOUN
admet-275	126	4	and	and	CCONJ
admet-275	126	5	cimetidine	cimetidine	NOUN
admet-275	126	6	induced	induce	VERB
admet-275	126	7	a	a	DET
admet-275	126	8	high	high	ADJ
admet-275	126	9	increase	increase	NOUN
admet-275	126	10	of	of	ADP
admet-275	126	11	erlotinib	erlotinib	NOUN
admet-275	126	12	accumulation	accumulation	NOUN
admet-275	126	13	,	,	PUNCT
admet-275	126	14	in	in	ADP
admet-275	126	15	contrast	contrast	NOUN
admet-275	126	16	to	to	ADP
admet-275	126	17	gefitinib	gefitinib	NOUN
admet-275	126	18	.	.	PUNCT
admet-275	127	1	amantadine	amantadine	NOUN
admet-275	127	2	and	and	CCONJ
admet-275	127	3	β	β	NOUN
admet-275	127	4	-	-	NOUN
admet-275	127	5	estradiol	estradiol	PROPN
admet-275	127	6	only	only	ADV
admet-275	127	7	induced	induce	VERB
admet-275	127	8	a	a	DET
admet-275	127	9	slight	slight	ADJ
admet-275	127	10	decrease	decrease	NOUN
admet-275	127	11	of	of	ADP
admet-275	127	12	erlotinib	erlotinib	NOUN
admet-275	127	13	accumulation	accumulation	NOUN
admet-275	127	14	.	.	PUNCT
admet-275	128	1	therefore	therefore	ADV
admet-275	128	2	hoct	hoct	PROPN
admet-275	128	3	is	be	AUX
admet-275	128	4	not	not	PART
admet-275	128	5	involved	involve	VERB
admet-275	128	6	in	in	ADP
admet-275	128	7	erlotinib	erlotinib	NOUN
admet-275	128	8	uptake	uptake	ADJ
admet-275	128	9	.	.	PUNCT
admet-275	129	1	the	the	DET
admet-275	129	2	effect	effect	NOUN
admet-275	129	3	of	of	ADP
admet-275	129	4	hoct	hoct	NOUN
admet-275	129	5	inhibitors	inhibitor	NOUN
admet-275	129	6	on	on	ADP
admet-275	129	7	sunitinib	sunitinib	NOUN
admet-275	129	8	and	and	CCONJ
admet-275	129	9	crizotinib	crizotinib	VERB
admet-275	129	10	was	be	AUX
admet-275	129	11	the	the	DET
admet-275	129	12	same	same	ADJ
admet-275	129	13	,	,	PUNCT
admet-275	129	14	except	except	SCONJ
admet-275	129	15	for	for	ADP
admet-275	129	16	verapamil	verapamil	NOUN
admet-275	129	17	.	.	PUNCT
admet-275	130	1	verapamil	verapamil	NOUN
admet-275	130	2	caused	cause	VERB
admet-275	130	3	a	a	DET
admet-275	130	4	slight	slight	ADJ
admet-275	130	5	increase	increase	NOUN
admet-275	130	6	in	in	ADP
admet-275	130	7	sunitinib	sunitinib	NOUN
admet-275	130	8	accumulation	accumulation	NOUN
admet-275	130	9	,	,	PUNCT
admet-275	130	10	but	but	CCONJ
admet-275	130	11	a	a	DET
admet-275	130	12	slight	slight	ADJ
admet-275	130	13	decrease	decrease	NOUN
admet-275	130	14	in	in	ADP
admet-275	130	15	crizotinib	crizotinib	ADJ
admet-275	130	16	accumulation	accumulation	NOUN
admet-275	130	17	.	.	PUNCT
admet-275	131	1	desipramine	desipramine	PROPN
admet-275	131	2	decreased	decrease	VERB
admet-275	131	3	sunitinib	sunitinib	NOUN
admet-275	131	4	and	and	CCONJ
admet-275	131	5	crizotinib	crizotinib	VERB
admet-275	131	6	accumulation	accumulation	NOUN
admet-275	131	7	,	,	PUNCT
admet-275	131	8	which	which	PRON
admet-275	131	9	indicates	indicate	VERB
admet-275	131	10	that	that	SCONJ
admet-275	131	11	hoct1	hoct1	NOUN
admet-275	131	12	,	,	PUNCT
admet-275	131	13	2	2	NUM
admet-275	131	14	and	and	CCONJ
admet-275	131	15	3	3	NUM
admet-275	131	16	are	be	AUX
admet-275	131	17	involved	involve	VERB
admet-275	131	18	in	in	ADP
admet-275	131	19	sunitinib	sunitinib	NOUN
admet-275	131	20	and	and	CCONJ
admet-275	131	21	crizotinib	crizotinib	VERB
admet-275	131	22	uptake	uptake	ADJ
admet-275	131	23	.	.	PUNCT
admet-275	132	1	dasatinib	dasatinib	NOUN
admet-275	132	2	accumulation	accumulation	NOUN
admet-275	132	3	was	be	AUX
admet-275	132	4	inhibited	inhibit	VERB
admet-275	132	5	equally	equally	ADV
admet-275	132	6	by	by	ADP
admet-275	132	7	all	all	PRON
admet-275	132	8	of	of	ADP
admet-275	132	9	the	the	DET
admet-275	132	10	hoct	hoct	NOUN
admet-275	132	11	inhibitors	inhibitor	NOUN
admet-275	132	12	,	,	PUNCT
admet-275	132	13	except	except	SCONJ
admet-275	132	14	for	for	ADP
admet-275	132	15	verapamil	verapamil	NOUN
admet-275	132	16	.	.	PUNCT
admet-275	133	1	besides	besides	SCONJ
admet-275	133	2	hoct1	hoct1	NOUN
admet-275	133	3	,	,	PUNCT
admet-275	133	4	verapamil	verapamil	NOUN
admet-275	133	5	also	also	ADV
admet-275	133	6	inhibits	inhibit	VERB
admet-275	133	7	p	p	X
admet-275	133	8	-	-	PUNCT
admet-275	133	9	gp	gp	NOUN
admet-275	133	10	,	,	PUNCT
admet-275	133	11	an	an	DET
admet-275	133	12	efflux	efflux	NOUN
admet-275	133	13	transporter	transporter	NOUN
admet-275	133	14	,	,	PUNCT
admet-275	133	15	resulting	result	VERB
admet-275	133	16	in	in	ADP
admet-275	133	17	a	a	DET
admet-275	133	18	3	3	NUM
admet-275	133	19	-	-	ADJ
admet-275	133	20	fold	fold	ADJ
admet-275	133	21	increase	increase	NOUN
admet-275	133	22	of	of	ADP
admet-275	133	23	dasatinib	dasatinib	NOUN
admet-275	133	24	accumulation	accumulation	NOUN
admet-275	133	25	.	.	PUNCT
admet-275	134	1	these	these	DET
admet-275	134	2	results	result	NOUN
admet-275	134	3	indicate	indicate	VERB
admet-275	134	4	that	that	SCONJ
admet-275	134	5	hocts	hoct	NOUN
admet-275	134	6	are	be	AUX
admet-275	134	7	involved	involve	VERB
admet-275	134	8	in	in	ADP
admet-275	134	9	dasatinib	dasatinib	NOUN
admet-275	134	10	influx	influx	VERB
admet-275	134	11	and	and	CCONJ
admet-275	134	12	p	p	X
admet-275	134	13	-	-	PUNCT
admet-275	134	14	gp	gp	NOUN
admet-275	134	15	is	be	AUX
admet-275	134	16	involved	involve	VERB
admet-275	134	17	in	in	ADP
admet-275	134	18	dasatinib	dasatinib	NOUN
admet-275	134	19	efflux	efflux	VERB
admet-275	134	20	.	.	PUNCT
admet-275	135	1	the	the	DET
admet-275	135	2	influence	influence	NOUN
admet-275	135	3	of	of	ADP
admet-275	135	4	the	the	DET
admet-275	135	5	hoct	hoct	NOUN
admet-275	135	6	inhibitors	inhibitor	NOUN
admet-275	135	7	on	on	ADP
admet-275	135	8	sorafenib	sorafenib	NOUN
admet-275	135	9	accumulation	accumulation	NOUN
admet-275	135	10	is	be	AUX
admet-275	135	11	completely	completely	ADV
admet-275	135	12	different	different	ADJ
admet-275	135	13	,	,	PUNCT
admet-275	135	14	compared	compare	VERB
admet-275	135	15	to	to	ADP
admet-275	135	16	dasatinib	dasatinib	NOUN
admet-275	135	17	accumulation	accumulation	NOUN
admet-275	135	18	.	.	PUNCT
admet-275	136	1	amantadine	amantadine	NOUN
admet-275	136	2	and	and	CCONJ
admet-275	136	3	β	β	NOUN
admet-275	136	4	-	-	NOUN
admet-275	136	5	estradiol	estradiol	PROPN
admet-275	136	6	did	do	AUX
admet-275	136	7	not	not	PART
admet-275	136	8	show	show	VERB
admet-275	136	9	any	any	DET
admet-275	136	10	effect	effect	NOUN
admet-275	136	11	and	and	CCONJ
admet-275	136	12	verapamil	verapamil	NOUN
admet-275	136	13	only	only	ADV
admet-275	136	14	induced	induce	VERB
admet-275	136	15	a	a	DET
admet-275	136	16	slight	slight	ADJ
admet-275	136	17	increase	increase	NOUN
admet-275	136	18	,	,	PUNCT
admet-275	136	19	whereas	whereas	SCONJ
admet-275	136	20	desipramine	desipramine	NOUN
admet-275	136	21	and	and	CCONJ
admet-275	136	22	cimetidine	cimetidine	NOUN
admet-275	136	23	decreased	decrease	VERB
admet-275	136	24	sorafenib	sorafenib	NOUN
admet-275	136	25	accumulation	accumulation	NOUN
admet-275	136	26	.	.	PUNCT
admet-275	137	1	honeywell	honeywell	PROPN
admet-275	137	2	et	et	PROPN
admet-275	137	3	al	al	PROPN
admet-275	137	4	.	.	PROPN
admet-275	137	5	admet	admet	PROPN
admet-275	137	6	&	&	CCONJ
admet-275	137	7	dmpk	dmpk	PROPN
admet-275	137	8	4(1	4(1	NOUN
admet-275	137	9	)	)	PUNCT
admet-275	137	10	(	(	PUNCT
admet-275	137	11	2016	2016	NUM
admet-275	137	12	)	)	PUNCT
admet-275	137	13	23	23	NUM
admet-275	137	14	-	-	SYM
admet-275	137	15	34	34	NUM
admet-275	137	16	28	28	NUM
admet-275	137	17	2	2	NUM
admet-275	137	18	4	4	NUM
admet-275	137	19	6	6	NUM
admet-275	137	20	0	0	NUM
admet-275	137	21	20	20	NUM
admet-275	137	22	40	40	NUM
admet-275	137	23	60	60	NUM
admet-275	137	24	80	80	NUM
admet-275	137	25	4	4	NUM
admet-275	137	26	°	°	ADP
admet-275	137	27	c	c	NOUN
admet-275	137	28	37	37	NUM
admet-275	137	29	°	°	NOUN
admet-275	137	30	c	c	NOUN
admet-275	137	31	time	time	NOUN
admet-275	137	32	(	(	PUNCT
admet-275	137	33	hours	hour	NOUN
admet-275	137	34	)	)	PUNCT
admet-275	137	35	a	a	DET
admet-275	137	36	c	c	NOUN
admet-275	137	37	c	c	X
admet-275	137	38	u	u	NOUN
admet-275	137	39	m	m	VERB
admet-275	137	40	u	u	NOUN
admet-275	137	41	la	la	X
admet-275	137	42	ti	ti	X
admet-275	137	43	o	o	NOUN
admet-275	137	44	n	n	PROPN
admet-275	137	45	(	(	PUNCT
admet-275	137	46	n	n	CCONJ
admet-275	137	47	g	g	PROPN
admet-275	137	48	/	/	SYM
admet-275	137	49	m	m	PROPN
admet-275	137	50	g	g	NOUN
admet-275	137	51	p	p	X
admet-275	137	52	ro	ro	X
admet-275	137	53	te	te	INTJ
admet-275	137	54	in	in	ADP
admet-275	137	55	)	)	PUNCT
admet-275	137	56	2	2	NUM
admet-275	137	57	4	4	NUM
admet-275	137	58	6	6	NUM
admet-275	137	59	0	0	NUM
admet-275	137	60	500	500	NUM
admet-275	137	61	1000	1000	NUM
admet-275	137	62	1500	1500	NUM
admet-275	137	63	2000	2000	NUM
admet-275	137	64	4	4	NUM
admet-275	137	65	°	°	ADP
admet-275	137	66	c	c	NOUN
admet-275	137	67	37	37	NUM
admet-275	137	68	°	°	NOUN
admet-275	137	69	c	c	NOUN
admet-275	137	70	time	time	NOUN
admet-275	137	71	(	(	PUNCT
admet-275	137	72	hours	hour	NOUN
admet-275	137	73	)	)	PUNCT
admet-275	137	74	2	2	NUM
admet-275	137	75	4	4	NUM
admet-275	137	76	6	6	NUM
admet-275	137	77	0	0	NUM
admet-275	137	78	5000	5000	NUM
admet-275	137	79	10000	10000	NUM
admet-275	137	80	15000	15000	NUM
admet-275	137	81	4	4	NUM
admet-275	137	82	°	°	ADP
admet-275	137	83	c	c	NOUN
admet-275	137	84	37	37	NUM
admet-275	137	85	°	°	NOUN
admet-275	137	86	c	c	NOUN
admet-275	137	87	time	time	NOUN
admet-275	137	88	(	(	PUNCT
admet-275	137	89	hours	hour	NOUN
admet-275	137	90	)	)	PUNCT
admet-275	137	91	a	a	DET
admet-275	137	92	c	c	NOUN
admet-275	137	93	c	c	X
admet-275	137	94	u	u	NOUN
admet-275	137	95	m	m	VERB
admet-275	137	96	u	u	NOUN
admet-275	137	97	la	la	X
admet-275	137	98	ti	ti	X
admet-275	137	99	o	o	NOUN
admet-275	137	100	n	n	PROPN
admet-275	137	101	(	(	PUNCT
admet-275	137	102	n	n	CCONJ
admet-275	137	103	g	g	PROPN
admet-275	137	104	/	/	SYM
admet-275	137	105	m	m	PROPN
admet-275	137	106	g	g	NOUN
admet-275	137	107	p	p	X
admet-275	137	108	ro	ro	X
admet-275	137	109	te	te	INTJ
admet-275	137	110	in	in	ADP
admet-275	137	111	)	)	PUNCT
admet-275	137	112	2	2	NUM
admet-275	137	113	4	4	NUM
admet-275	137	114	6	6	NUM
admet-275	137	115	0	0	NUM
admet-275	137	116	2000	2000	NUM
admet-275	137	117	4000	4000	NUM
admet-275	137	118	6000	6000	NUM
admet-275	137	119	4	4	NUM
admet-275	137	120	°	°	ADP
admet-275	137	121	c	c	NOUN
admet-275	137	122	37	37	NUM
admet-275	137	123	°	°	NOUN
admet-275	137	124	c	c	NOUN
admet-275	137	125	time	time	NOUN
admet-275	137	126	(	(	PUNCT
admet-275	137	127	hours	hour	NOUN
admet-275	137	128	)	)	PUNCT
admet-275	137	129	2	2	NUM
admet-275	137	130	4	4	NUM
admet-275	137	131	6	6	NUM
admet-275	137	132	0	0	NUM
admet-275	137	133	2000	2000	NUM
admet-275	137	134	4000	4000	NUM
admet-275	137	135	6000	6000	NUM
admet-275	137	136	8000	8000	NUM
admet-275	137	137	10000	10000	NUM
admet-275	137	138	4	4	NUM
admet-275	137	139	°	°	ADP
admet-275	137	140	c	c	NOUN
admet-275	137	141	37	37	NUM
admet-275	137	142	°	°	NOUN
admet-275	137	143	c	c	NOUN
admet-275	137	144	time	time	NOUN
admet-275	137	145	(	(	PUNCT
admet-275	137	146	hours	hour	NOUN
admet-275	137	147	)	)	PUNCT
admet-275	137	148	a	a	DET
admet-275	137	149	c	c	NOUN
admet-275	137	150	c	c	X
admet-275	137	151	u	u	NOUN
admet-275	137	152	m	m	VERB
admet-275	137	153	u	u	NOUN
admet-275	137	154	la	la	X
admet-275	137	155	ti	ti	X
admet-275	137	156	o	o	NOUN
admet-275	137	157	n	n	PROPN
admet-275	137	158	(	(	PUNCT
admet-275	137	159	n	n	CCONJ
admet-275	137	160	g	g	PROPN
admet-275	137	161	/	/	SYM
admet-275	137	162	m	m	PROPN
admet-275	137	163	g	g	NOUN
admet-275	137	164	p	p	X
admet-275	137	165	ro	ro	X
admet-275	137	166	te	te	INTJ
admet-275	137	167	in	in	ADP
admet-275	137	168	)	)	PUNCT
admet-275	137	169	2	2	NUM
admet-275	137	170	4	4	NUM
admet-275	137	171	6	6	NUM
admet-275	137	172	0	0	NUM
admet-275	137	173	50	50	NUM
admet-275	137	174	100	100	NUM
admet-275	137	175	150	150	NUM
admet-275	137	176	200	200	NUM
admet-275	137	177	4	4	NUM
admet-275	137	178	°	°	NOUN
admet-275	137	179	c	c	NOUN
admet-275	137	180	37	37	NUM
admet-275	137	181	°	°	NOUN
admet-275	137	182	c	c	NOUN
admet-275	137	183	time	time	NOUN
admet-275	137	184	(	(	PUNCT
admet-275	137	185	hours	hour	NOUN
admet-275	137	186	)	)	PUNCT
admet-275	137	187	figure	figure	NOUN
admet-275	137	188	2	2	NUM
admet-275	137	189	.	.	PUNCT
admet-275	137	190	influence	influence	NOUN
admet-275	137	191	of	of	ADP
admet-275	137	192	temperature	temperature	NOUN
admet-275	137	193	(	(	PUNCT
admet-275	137	194	4	4	NUM
admet-275	137	195	°	°	ADP
admet-275	137	196	c	c	NOUN
admet-275	137	197	and	and	CCONJ
admet-275	137	198	37	37	NUM
admet-275	137	199	°	°	NOUN
admet-275	137	200	c	c	NOUN
admet-275	137	201	)	)	PUNCT
admet-275	137	202	on	on	ADP
admet-275	137	203	the	the	DET
admet-275	137	204	cellular	cellular	ADJ
admet-275	137	205	accumulation	accumulation	NOUN
admet-275	137	206	of	of	ADP
admet-275	137	207	10	10	NUM
admet-275	137	208	µm	µm	NOUN
admet-275	137	209	erlotinib	erlotinib	PROPN
admet-275	137	210	(	(	PUNCT
admet-275	137	211	a	a	NOUN
admet-275	137	212	)	)	PUNCT
admet-275	137	213	;	;	PUNCT
admet-275	137	214	gefitinib	gefitinib	NOUN
admet-275	137	215	(	(	PUNCT
admet-275	137	216	b	b	NOUN
admet-275	137	217	)	)	PUNCT
admet-275	137	218	;	;	PUNCT
admet-275	137	219	sunitinib	sunitinib	NOUN
admet-275	137	220	(	(	PUNCT
admet-275	137	221	c	c	NOUN
admet-275	137	222	)	)	PUNCT
admet-275	137	223	;	;	PUNCT
admet-275	137	224	sorafenib	sorafenib	NOUN
admet-275	137	225	(	(	PUNCT
admet-275	137	226	d	d	NOUN
admet-275	137	227	)	)	PUNCT
admet-275	137	228	;	;	PUNCT
admet-275	137	229	crizotinib	crizotinib	X
admet-275	137	230	(	(	PUNCT
admet-275	137	231	e	e	NOUN
admet-275	137	232	)	)	PUNCT
admet-275	137	233	and	and	CCONJ
admet-275	137	234	1	1	NUM
admet-275	137	235	µm	µm	ADP
admet-275	137	236	dasatinib	dasatinib	NOUN
admet-275	137	237	(	(	PUNCT
admet-275	137	238	f	f	X
admet-275	137	239	)	)	PUNCT
admet-275	137	240	in	in	ADP
admet-275	137	241	caco-2	caco-2	NUM
admet-275	137	242	cells	cell	NOUN
admet-275	137	243	.	.	PUNCT
admet-275	138	1	all	all	DET
admet-275	138	2	values	value	NOUN
admet-275	138	3	are	be	AUX
admet-275	138	4	reported	report	VERB
admet-275	138	5	as	as	ADP
admet-275	138	6	the	the	DET
admet-275	138	7	mean	mean	PROPN
admet-275	138	8	±	±	NUM
admet-275	138	9	sem	sem	NOUN
admet-275	138	10	of	of	ADP
admet-275	138	11	n=2	n=2	ADV
admet-275	138	12	and	and	CCONJ
admet-275	138	13	expressed	express	VERB
admet-275	138	14	as	as	ADP
admet-275	138	15	the	the	DET
admet-275	138	16	ng	ng	PROPN
admet-275	138	17	accumulated	accumulate	VERB
admet-275	138	18	per	per	ADP
admet-275	138	19	µg	µg	NOUN
admet-275	138	20	of	of	ADP
admet-275	138	21	sample	sample	NOUN
admet-275	138	22	protein	protein	NOUN
admet-275	138	23	.	.	PUNCT
admet-275	139	1	effect	effect	NOUN
admet-275	139	2	of	of	ADP
admet-275	139	3	hoct	hoct	NOUN
admet-275	139	4	inhibition	inhibition	NOUN
admet-275	139	5	basolateral	basolateral	ADJ
admet-275	139	6	transport	transport	NOUN
admet-275	139	7	within	within	ADP
admet-275	139	8	an	an	DET
admet-275	139	9	intestinal	intestinal	ADJ
admet-275	139	10	model	model	NOUN
admet-275	139	11	to	to	PART
admet-275	139	12	further	far	ADV
admet-275	139	13	investigate	investigate	VERB
admet-275	139	14	the	the	DET
admet-275	139	15	influence	influence	NOUN
admet-275	139	16	of	of	ADP
admet-275	139	17	hoct	hoct	NOUN
admet-275	139	18	on	on	ADP
admet-275	139	19	the	the	DET
admet-275	139	20	uptake	uptake	NOUN
admet-275	139	21	of	of	ADP
admet-275	139	22	the	the	DET
admet-275	139	23	six	six	NUM
admet-275	139	24	tkis	tkis	NOUN
admet-275	139	25	,	,	PUNCT
admet-275	139	26	accumulation	accumulation	NOUN
admet-275	139	27	and	and	CCONJ
admet-275	139	28	transport	transport	NOUN
admet-275	139	29	studies	study	NOUN
admet-275	139	30	were	be	AUX
admet-275	139	31	performed	perform	VERB
admet-275	139	32	with	with	ADP
admet-275	139	33	the	the	DET
admet-275	139	34	becton	becton	PROPN
admet-275	139	35	dickinson	dickinson	PROPN
admet-275	139	36	bioscience	bioscience	PROPN
admet-275	139	37	biocoat	biocoat	PROPN
admet-275	139	38	®	®	PROPN
admet-275	139	39	hts	hts	PROPN
admet-275	139	40	caco-2	caco-2	NUM
admet-275	139	41	assay	assay	NOUN
admet-275	139	42	system	system	NOUN
admet-275	139	43	.	.	PUNCT
admet-275	140	1	verapamil	verapamil	NOUN
admet-275	140	2	,	,	PUNCT
admet-275	140	3	desipramine	desipramine	NOUN
admet-275	140	4	and	and	CCONJ
admet-275	140	5	cimetidine	cimetidine	NOUN
admet-275	140	6	demonstrated	demonstrate	VERB
admet-275	140	7	the	the	DET
admet-275	140	8	most	most	ADV
admet-275	140	9	pronounced	pronounced	ADJ
admet-275	140	10	effect	effect	NOUN
admet-275	140	11	in	in	ADP
admet-275	140	12	the	the	DET
admet-275	140	13	accumulation	accumulation	NOUN
admet-275	140	14	study	study	NOUN
admet-275	140	15	(	(	PUNCT
admet-275	140	16	figure	figure	NOUN
admet-275	140	17	3	3	NUM
admet-275	140	18	)	)	PUNCT
admet-275	140	19	,	,	PUNCT
admet-275	140	20	these	these	DET
admet-275	140	21	hoct	hoct	NOUN
admet-275	140	22	inhibiters	inhibiter	NOUN
admet-275	140	23	were	be	AUX
admet-275	140	24	used	use	VERB
admet-275	140	25	in	in	ADP
admet-275	140	26	the	the	DET
admet-275	140	27	transwell	transwell	NOUN
admet-275	140	28	system	system	NOUN
admet-275	140	29	.	.	PUNCT
admet-275	141	1	none	none	NOUN
admet-275	141	2	of	of	ADP
admet-275	141	3	the	the	DET
admet-275	141	4	three	three	NUM
admet-275	141	5	hoct	hoct	NOUN
admet-275	141	6	inhibitors	inhibitor	NOUN
admet-275	141	7	had	have	VERB
admet-275	141	8	any	any	DET
admet-275	141	9	effect	effect	NOUN
admet-275	141	10	on	on	ADP
admet-275	141	11	the	the	DET
admet-275	141	12	apical	apical	ADJ
admet-275	141	13	to	to	ADP
admet-275	141	14	basolateral	basolateral	ADJ
admet-275	141	15	transport	transport	NOUN
admet-275	141	16	of	of	ADP
admet-275	141	17	erlotinib	erlotinib	PROPN
admet-275	141	18	(	(	PUNCT
admet-275	141	19	figure	figure	NOUN
admet-275	141	20	4a	4a	NUM
admet-275	141	21	)	)	PUNCT
admet-275	141	22	,	,	PUNCT
admet-275	141	23	which	which	PRON
admet-275	141	24	is	be	AUX
admet-275	141	25	in	in	ADP
admet-275	141	26	line	line	NOUN
admet-275	141	27	with	with	ADP
admet-275	141	28	the	the	DET
admet-275	141	29	minor	minor	ADJ
admet-275	141	30	effect	effect	NOUN
admet-275	141	31	on	on	ADP
admet-275	141	32	the	the	DET
admet-275	141	33	accumulation	accumulation	NOUN
admet-275	141	34	in	in	ADP
admet-275	141	35	caco-2	caco-2	NUM
admet-275	141	36	cells	cell	NOUN
admet-275	141	37	(	(	PUNCT
admet-275	141	38	figure	figure	NOUN
admet-275	141	39	2a	2a	NUM
admet-275	141	40	)	)	PUNCT
admet-275	141	41	.	.	PUNCT
admet-275	142	1	however	however	ADV
admet-275	142	2	,	,	PUNCT
admet-275	142	3	cellular	cellular	ADJ
admet-275	142	4	erlotinib	erlotinib	NOUN
admet-275	142	5	accumulation	accumulation	NOUN
admet-275	142	6	was	be	AUX
admet-275	142	7	decreased	decrease	VERB
admet-275	142	8	at	at	ADP
admet-275	142	9	the	the	DET
admet-275	142	10	end	end	NOUN
admet-275	142	11	of	of	ADP
admet-275	142	12	the	the	DET
admet-275	142	13	incubation	incubation	NOUN
admet-275	142	14	(	(	PUNCT
admet-275	142	15	figure	figure	NOUN
admet-275	142	16	5	5	NUM
admet-275	142	17	)	)	PUNCT
admet-275	142	18	.	.	PUNCT
admet-275	143	1	in	in	ADP
admet-275	143	2	contrast	contrast	NOUN
admet-275	143	3	to	to	ADP
admet-275	143	4	erlotinib	erlotinib	NOUN
admet-275	143	5	,	,	PUNCT
admet-275	143	6	gefitinib	gefitinib	NOUN
admet-275	143	7	permeation	permeation	NOUN
admet-275	143	8	was	be	AUX
admet-275	143	9	affected	affect	VERB
admet-275	143	10	by	by	ADP
admet-275	143	11	oct	oct	PROPN
admet-275	143	12	inhibitors	inhibitor	NOUN
admet-275	143	13	.	.	PUNCT
admet-275	144	1	desipramine	desipramine	NOUN
admet-275	144	2	increased	increase	VERB
admet-275	144	3	apical	apical	ADV
admet-275	144	4	to	to	ADP
admet-275	144	5	basolateral	basolateral	ADJ
admet-275	144	6	transport	transport	NOUN
admet-275	144	7	of	of	ADP
admet-275	144	8	gefitinib	gefitinib	NOUN
admet-275	144	9	(	(	PUNCT
admet-275	144	10	figure	figure	NOUN
admet-275	144	11	4b	4b	PROPN
admet-275	144	12	)	)	PUNCT
admet-275	144	13	,	,	PUNCT
admet-275	144	14	yet	yet	CCONJ
admet-275	144	15	decreased	decrease	VERB
admet-275	144	16	cellular	cellular	ADJ
admet-275	144	17	gefitinib	gefitinib	NOUN
admet-275	144	18	accumulation	accumulation	NOUN
admet-275	144	19	(	(	PUNCT
admet-275	144	20	figure	figure	NOUN
admet-275	144	21	5	5	NUM
admet-275	144	22	)	)	PUNCT
admet-275	144	23	.	.	PUNCT
admet-275	145	1	therefore	therefore	ADV
admet-275	145	2	,	,	PUNCT
admet-275	145	3	there	there	PRON
admet-275	145	4	may	may	AUX
admet-275	145	5	be	be	AUX
admet-275	145	6	increased	increase	VERB
admet-275	145	7	mass	mass	ADJ
admet-275	145	8	transport	transport	NOUN
admet-275	145	9	from	from	ADP
admet-275	145	10	apical	apical	ADJ
admet-275	145	11	to	to	ADP
admet-275	145	12	basolateral	basolateral	ADJ
admet-275	145	13	side	side	NOUN
admet-275	145	14	.	.	PUNCT
admet-275	146	1	cimetidine	cimetidine	PROPN
admet-275	146	2	did	do	AUX
admet-275	146	3	not	not	PART
admet-275	146	4	affect	affect	VERB
admet-275	146	5	permeation	permeation	NOUN
admet-275	146	6	and	and	CCONJ
admet-275	146	7	cellular	cellular	ADJ
admet-275	146	8	accumulation	accumulation	NOUN
admet-275	146	9	of	of	ADP
admet-275	146	10	gefitinib	gefitinib	NOUN
admet-275	146	11	,	,	PUNCT
admet-275	146	12	while	while	SCONJ
admet-275	146	13	verapamil	verapamil	NOUN
admet-275	146	14	increases	increase	VERB
admet-275	146	15	cellular	cellular	ADJ
admet-275	146	16	accumulation	accumulation	NOUN
admet-275	146	17	and	and	CCONJ
admet-275	146	18	permeation	permeation	NOUN
admet-275	146	19	.	.	PUNCT
admet-275	147	1	a	a	DET
admet-275	147	2	f	f	X
admet-275	147	3	d	d	X
admet-275	147	4	b	b	PROPN
admet-275	147	5	c	c	NOUN
admet-275	147	6	e	e	X
admet-275	147	7	admet	admet	PROPN
admet-275	147	8	&	&	CCONJ
admet-275	147	9	dmpk	dmpk	PROPN
admet-275	147	10	4(1	4(1	NOUN
admet-275	147	11	)	)	PUNCT
admet-275	147	12	(	(	PUNCT
admet-275	147	13	2016	2016	NUM
admet-275	147	14	)	)	PUNCT
admet-275	147	15	23	23	NUM
admet-275	147	16	-	-	SYM
admet-275	147	17	34	34	NUM
admet-275	147	18	transport	transport	NOUN
admet-275	147	19	mechanism	mechanism	NOUN
admet-275	147	20	of	of	ADP
admet-275	147	21	tk	tk	PROPN
admet-275	147	22	inhibitors	inhibitor	NOUN
admet-275	147	23	doi	doi	NOUN
admet-275	147	24	:	:	PUNCT
admet-275	147	25	10.5599	10.5599	NUM
admet-275	147	26	/	/	SYM
admet-275	147	27	admet.4.1.275	admet.4.1.275	PROPN
admet-275	147	28	29	29	NUM
admet-275	147	29	figure	figure	NOUN
admet-275	147	30	3	3	NUM
admet-275	147	31	.	.	PUNCT
admet-275	147	32	relative	relative	ADJ
admet-275	147	33	accumulation	accumulation	NOUN
admet-275	147	34	after	after	ADP
admet-275	147	35	the	the	DET
admet-275	147	36	exposure	exposure	NOUN
admet-275	147	37	of	of	ADP
admet-275	147	38	10	10	NUM
admet-275	147	39	μm	μm	NUM
admet-275	147	40	erlotinib	erlotinib	NOUN
admet-275	147	41	,	,	PUNCT
admet-275	147	42	gefitinib	gefitinib	NOUN
admet-275	147	43	,	,	PUNCT
admet-275	147	44	sorafenib	sorafenib	NOUN
admet-275	147	45	,	,	PUNCT
admet-275	147	46	sunitinib	sunitinib	NOUN
admet-275	147	47	,	,	PUNCT
admet-275	147	48	crizotinib	crizotinib	VERB
admet-275	147	49	and	and	CCONJ
admet-275	147	50	1	1	NUM
admet-275	147	51	μm	μm	NOUN
admet-275	147	52	dasatinib	dasatinib	NOUN
admet-275	147	53	with	with	ADP
admet-275	147	54	and	and	CCONJ
admet-275	147	55	without	without	ADP
admet-275	147	56	hoct	hoct	NOUN
admet-275	147	57	inhibitors	inhibitor	NOUN
admet-275	147	58	in	in	ADP
admet-275	147	59	caco-2	caco-2	NUM
admet-275	147	60	cells	cell	NOUN
admet-275	147	61	(	(	PUNCT
admet-275	147	62	100	100	NUM
admet-275	147	63	μm	μm	NUM
admet-275	147	64	amantadine	amantadine	NOUN
admet-275	147	65	,	,	PUNCT
admet-275	147	66	cimetidine	cimetidine	NOUN
admet-275	147	67	or	or	CCONJ
admet-275	147	68	desipramine	desipramine	NOUN
admet-275	147	69	;	;	PUNCT
admet-275	147	70	10	10	NUM
admet-275	147	71	μm	μm	NOUN
admet-275	147	72	-estradiol	-estradiol	PROPN
admet-275	147	73	and	and	CCONJ
admet-275	147	74	verapamil	verapamil	NOUN
admet-275	147	75	.	.	PUNCT
admet-275	148	1	values	value	NOUN
admet-275	148	2	are	be	AUX
admet-275	148	3	presented	present	VERB
admet-275	148	4	as	as	SCONJ
admet-275	148	5	percent	percent	NOUN
admet-275	148	6	accumulation	accumulation	NOUN
admet-275	148	7	observed	observe	VERB
admet-275	148	8	relative	relative	ADJ
admet-275	148	9	to	to	ADP
admet-275	148	10	control	control	NOUN
admet-275	148	11	(	(	PUNCT
admet-275	148	12	without	without	ADP
admet-275	148	13	hoct	hoct	PROPN
admet-275	148	14	inhibitor	inhibitor	NOUN
admet-275	148	15	)	)	PUNCT
admet-275	148	16	of	of	ADP
admet-275	148	17	one	one	NUM
admet-275	148	18	experiment	experiment	NOUN
admet-275	148	19	.	.	PUNCT
admet-275	149	1	cellular	cellular	ADJ
admet-275	149	2	accumulation	accumulation	NOUN
admet-275	149	3	was	be	AUX
admet-275	149	4	normalized	normalize	VERB
admet-275	149	5	to	to	PART
admet-275	149	6	cell	cell	VERB
admet-275	149	7	protein	protein	NOUN
admet-275	149	8	amount	amount	NOUN
admet-275	149	9	.	.	PUNCT
admet-275	150	1	15	15	NUM
admet-275	150	2	30	30	NUM
admet-275	150	3	60	60	NUM
admet-275	150	4	90	90	NUM
admet-275	150	5	120	120	NUM
admet-275	150	6	180	180	NUM
admet-275	150	7	0	0	NUM
admet-275	150	8	500	500	NUM
admet-275	150	9	1000	1000	NUM
admet-275	150	10	1500	1500	NUM
admet-275	150	11	2000	2000	NUM
admet-275	150	12	control	control	NOUN
admet-275	150	13	verapamil	verapamil	NOUN
admet-275	150	14	desipramine	desipramine	NOUN
admet-275	150	15	cimetidine	cimetidine	VERB
admet-275	150	16	a	a	DET
admet-275	150	17	c	c	NOUN
admet-275	150	18	c	c	X
admet-275	150	19	u	u	NOUN
admet-275	150	20	m	m	PROPN
admet-275	150	21	a	a	PRON
admet-275	150	22	lt	lt	ADV
admet-275	150	23	iv	iv	PROPN
admet-275	150	24	e	e	NOUN
admet-275	150	25	m	m	VERB
admet-275	150	26	a	a	DET
admet-275	150	27	s	s	X
admet-275	150	28	s	s	PROPN
admet-275	150	29	t	t	PROPN
admet-275	150	30	ra	ra	PROPN
admet-275	150	31	n	n	PROPN
admet-275	151	1	s	s	PROPN
admet-275	151	2	p	p	NOUN
admet-275	151	3	o	o	X
admet-275	151	4	rt	rt	PROPN
admet-275	152	1	(	(	PUNCT
admet-275	152	2	p	p	NOUN
admet-275	152	3	m	m	PROPN
admet-275	152	4	o	o	NOUN
admet-275	152	5	l	l	NOUN
admet-275	152	6	)	)	PUNCT
admet-275	152	7	15	15	NUM
admet-275	152	8	30	30	NUM
admet-275	152	9	60	60	NUM
admet-275	152	10	90	90	NUM
admet-275	152	11	120	120	NUM
admet-275	152	12	180	180	NUM
admet-275	152	13	0	0	NUM
admet-275	152	14	100	100	NUM
admet-275	152	15	200	200	NUM
admet-275	152	16	300	300	NUM
admet-275	152	17	400	400	NUM
admet-275	152	18	500	500	NUM
admet-275	152	19	control	control	NOUN
admet-275	152	20	verapamil	verapamil	NOUN
admet-275	152	21	desipramine	desipramine	NOUN
admet-275	152	22	cimetidine	cimetidine	NOUN
admet-275	152	23	15	15	NUM
admet-275	152	24	30	30	NUM
admet-275	152	25	60	60	NUM
admet-275	152	26	90	90	NUM
admet-275	152	27	120	120	NUM
admet-275	152	28	180	180	NUM
admet-275	152	29	0	0	NUM
admet-275	152	30	100	100	NUM
admet-275	152	31	200	200	NUM
admet-275	152	32	300	300	NUM
admet-275	152	33	400	400	NUM
admet-275	152	34	500	500	NUM
admet-275	152	35	control	control	NOUN
admet-275	152	36	verapamil	verapamil	NOUN
admet-275	152	37	desipramine	desipramine	NOUN
admet-275	152	38	cimetidine	cimetidine	NOUN
admet-275	152	39	time	time	NOUN
admet-275	152	40	(	(	PUNCT
admet-275	152	41	minutes	minute	NOUN
admet-275	152	42	)	)	PUNCT
admet-275	153	1	a	a	DET
admet-275	153	2	c	c	NOUN
admet-275	153	3	c	c	X
admet-275	153	4	u	u	NOUN
admet-275	153	5	m	m	PROPN
admet-275	153	6	a	a	PRON
admet-275	153	7	lt	lt	ADV
admet-275	153	8	iv	iv	PROPN
admet-275	153	9	e	e	NOUN
admet-275	153	10	m	m	VERB
admet-275	153	11	a	a	PRON
admet-275	153	12	s	s	X
admet-275	153	13	s	s	PROPN
admet-275	153	14	t	t	PROPN
admet-275	153	15	ra	ra	PROPN
admet-275	154	1	n	n	PROPN
admet-275	154	2	s	s	PROPN
admet-275	154	3	p	p	NOUN
admet-275	154	4	o	o	X
admet-275	154	5	rt	rt	PROPN
admet-275	155	1	(	(	PUNCT
admet-275	155	2	p	p	NOUN
admet-275	155	3	m	m	PROPN
admet-275	155	4	o	o	NOUN
admet-275	155	5	l	l	NOUN
admet-275	155	6	)	)	PUNCT
admet-275	155	7	15	15	NUM
admet-275	155	8	30	30	NUM
admet-275	155	9	60	60	NUM
admet-275	155	10	90	90	NUM
admet-275	155	11	120	120	NUM
admet-275	155	12	180	180	NUM
admet-275	155	13	0	0	NUM
admet-275	155	14	100	100	NUM
admet-275	155	15	200	200	NUM
admet-275	155	16	300	300	NUM
admet-275	155	17	400	400	NUM
admet-275	155	18	500	500	NUM
admet-275	155	19	control	control	NOUN
admet-275	155	20	verapamil	verapamil	NOUN
admet-275	155	21	desipramine	desipramine	NOUN
admet-275	155	22	cimetidine	cimetidine	NOUN
admet-275	155	23	time	time	NOUN
admet-275	155	24	(	(	PUNCT
admet-275	155	25	minutes	minute	NOUN
admet-275	155	26	)	)	PUNCT
admet-275	155	27	15	15	NUM
admet-275	155	28	30	30	NUM
admet-275	155	29	60	60	NUM
admet-275	155	30	90	90	NUM
admet-275	155	31	120	120	NUM
admet-275	155	32	1800	1800	NUM
admet-275	155	33	100	100	NUM
admet-275	155	34	200	200	NUM
admet-275	155	35	300	300	NUM
admet-275	155	36	400	400	NUM
admet-275	155	37	500	500	NUM
admet-275	155	38	control	control	NOUN
admet-275	155	39	verapamil	verapamil	NOUN
admet-275	155	40	desipramine	desipramine	NOUN
admet-275	155	41	cimetidine	cimetidine	NOUN
admet-275	155	42	time	time	NOUN
admet-275	155	43	(	(	PUNCT
admet-275	155	44	minutes	minute	NOUN
admet-275	155	45	)	)	PUNCT
admet-275	155	46	15	15	NUM
admet-275	155	47	30	30	NUM
admet-275	155	48	60	60	NUM
admet-275	155	49	90	90	NUM
admet-275	155	50	120	120	NUM
admet-275	155	51	180	180	NUM
admet-275	155	52	0	0	NUM
admet-275	155	53	100	100	NUM
admet-275	155	54	200	200	NUM
admet-275	155	55	300	300	NUM
admet-275	155	56	control	control	NOUN
admet-275	155	57	verapamil	verapamil	NOUN
admet-275	155	58	desipramine	desipramine	PROPN
admet-275	155	59	cimetidine	cimetidine	NOUN
admet-275	155	60	figure	figure	NOUN
admet-275	155	61	4	4	NUM
admet-275	155	62	.	.	X
admet-275	155	63	accumulative	accumulative	ADJ
admet-275	155	64	mass	mass	PROPN
admet-275	155	65	transport	transport	NOUN
admet-275	155	66	from	from	ADP
admet-275	155	67	the	the	DET
admet-275	155	68	apical	apical	ADJ
admet-275	155	69	to	to	ADP
admet-275	155	70	basolateral	basolateral	ADJ
admet-275	155	71	side	side	NOUN
admet-275	155	72	after	after	ADP
admet-275	155	73	the	the	DET
admet-275	155	74	exposure	exposure	NOUN
admet-275	155	75	of	of	ADP
admet-275	155	76	10	10	NUM
admet-275	155	77	μm	μm	NOUN
admet-275	155	78	of	of	ADP
admet-275	155	79	erlotinib	erlotinib	NOUN
admet-275	155	80	(	(	PUNCT
admet-275	155	81	a	a	NOUN
admet-275	155	82	)	)	PUNCT
admet-275	155	83	,	,	PUNCT
admet-275	155	84	gefitinib	gefitinib	NOUN
admet-275	155	85	(	(	PUNCT
admet-275	155	86	b	b	NOUN
admet-275	155	87	)	)	PUNCT
admet-275	155	88	,	,	PUNCT
admet-275	155	89	sunitinib	sunitinib	NOUN
admet-275	155	90	(	(	PUNCT
admet-275	155	91	f	f	X
admet-275	155	92	)	)	PUNCT
admet-275	155	93	,	,	PUNCT
admet-275	155	94	sorafenib	sorafenib	NOUN
admet-275	155	95	(	(	PUNCT
admet-275	155	96	d	d	NOUN
admet-275	155	97	)	)	PUNCT
admet-275	155	98	and	and	CCONJ
admet-275	155	99	crizotinib	crizotinib	X
admet-275	155	100	(	(	PUNCT
admet-275	155	101	c	c	NOUN
admet-275	155	102	)	)	PUNCT
admet-275	155	103	.	.	PUNCT
admet-275	156	1	dasatinib	dasatinib	NOUN
admet-275	156	2	(	(	PUNCT
admet-275	156	3	e	e	NOUN
admet-275	156	4	)	)	PUNCT
admet-275	156	5	was	be	AUX
admet-275	156	6	used	use	VERB
admet-275	156	7	a	a	DET
admet-275	156	8	concentration	concentration	NOUN
admet-275	156	9	of	of	ADP
admet-275	156	10	1	1	NUM
admet-275	156	11	µm	µm	NOUN
admet-275	156	12	due	due	ADP
admet-275	156	13	to	to	ADP
admet-275	156	14	its	its	PRON
admet-275	156	15	higher	high	ADJ
admet-275	156	16	activity	activity	NOUN
admet-275	156	17	in	in	ADP
admet-275	156	18	translational	translational	ADJ
admet-275	156	19	cell	cell	NOUN
admet-275	156	20	culture	culture	NOUN
admet-275	156	21	.	.	PUNCT
admet-275	157	1	all	all	DET
admet-275	157	2	culturing	culture	VERB
admet-275	157	3	was	be	AUX
admet-275	157	4	performed	perform	VERB
admet-275	157	5	with	with	ADP
admet-275	157	6	and	and	CCONJ
admet-275	157	7	without	without	ADP
admet-275	157	8	the	the	DET
admet-275	157	9	addition	addition	NOUN
admet-275	157	10	of	of	ADP
admet-275	157	11	either	either	DET
admet-275	157	12	10	10	NUM
admet-275	157	13	μm	μm	NOUN
admet-275	157	14	verapamil	verapamil	NOUN
admet-275	157	15	,	,	PUNCT
admet-275	157	16	100	100	NUM
admet-275	157	17	μm	μm	NOUN
admet-275	157	18	desipramine	desipramine	NOUN
admet-275	157	19	or	or	CCONJ
admet-275	157	20	100	100	NUM
admet-275	157	21	µm	µm	ADP
admet-275	157	22	cimetidine	cimetidine	NOUN
admet-275	157	23	.	.	PUNCT
admet-275	158	1	values	value	NOUN
admet-275	158	2	presented	present	VERB
admet-275	158	3	are	be	AUX
admet-275	158	4	from	from	ADP
admet-275	158	5	one	one	NUM
admet-275	158	6	representative	representative	ADJ
admet-275	158	7	experiment	experiment	NOUN
admet-275	158	8	.	.	PUNCT
admet-275	159	1	cellular	cellular	ADJ
admet-275	159	2	accumulation	accumulation	NOUN
admet-275	159	3	was	be	AUX
admet-275	159	4	normalized	normalize	VERB
admet-275	159	5	to	to	PART
admet-275	159	6	cell	cell	VERB
admet-275	159	7	protein	protein	NOUN
admet-275	159	8	amount	amount	NOUN
admet-275	159	9	.	.	PUNCT
admet-275	160	1	the	the	DET
admet-275	160	2	hoct	hoct	PROPN
admet-275	160	3	inhibitors	inhibitor	NOUN
admet-275	160	4	desipramine	desipramine	NOUN
admet-275	160	5	,	,	PUNCT
admet-275	160	6	verapermil	verapermil	NOUN
admet-275	160	7	and	and	CCONJ
admet-275	160	8	cimetidine	cimetidine	NOUN
admet-275	160	9	had	have	VERB
admet-275	160	10	little	little	ADJ
admet-275	160	11	effect	effect	NOUN
admet-275	160	12	on	on	ADP
admet-275	160	13	the	the	DET
admet-275	160	14	permeation	permeation	NOUN
admet-275	160	15	of	of	ADP
admet-275	160	16	sunitinib	sunitinib	NOUN
admet-275	160	17	,	,	PUNCT
admet-275	160	18	sorafenib	sorafenib	NOUN
admet-275	160	19	and	and	CCONJ
admet-275	160	20	dasatinib	dasatinib	NOUN
admet-275	160	21	(	(	PUNCT
admet-275	160	22	figures	figure	NOUN
admet-275	160	23	4f	4f	NUM
admet-275	160	24	,	,	PUNCT
admet-275	160	25	4d	4d	NUM
admet-275	160	26	and	and	CCONJ
admet-275	160	27	4e	4e	NOUN
admet-275	160	28	,	,	PUNCT
admet-275	160	29	respectively	respectively	ADV
admet-275	160	30	)	)	PUNCT
admet-275	160	31	.	.	PUNCT
admet-275	161	1	however	however	ADV
admet-275	161	2	,	,	PUNCT
admet-275	161	3	both	both	DET
admet-275	161	4	crizotinib	crizotinib	ADJ
admet-275	161	5	(	(	PUNCT
admet-275	161	6	figure	figure	NOUN
admet-275	161	7	4c	4c	NOUN
admet-275	161	8	)	)	PUNCT
admet-275	161	9	and	and	CCONJ
admet-275	161	10	sunitinib	sunitinib	NOUN
admet-275	161	11	demonstrated	demonstrate	VERB
admet-275	161	12	a	a	DET
admet-275	161	13	small	small	ADJ
admet-275	161	14	monolayer	monolayer	NOUN
admet-275	161	15	accumulation	accumulation	NOUN
admet-275	161	16	with	with	ADP
admet-275	161	17	verapamil	verapamil	NOUN
admet-275	161	18	and	and	CCONJ
admet-275	161	19	cimetidine	cimetidine	NOUN
admet-275	161	20	whereas	whereas	SCONJ
admet-275	161	21	desipramine	desipramine	NOUN
admet-275	161	22	had	have	VERB
admet-275	161	23	little	little	ADJ
admet-275	161	24	or	or	CCONJ
admet-275	161	25	no	no	PRON
admet-275	161	26	effect	effect	NOUN
admet-275	161	27	,	,	PUNCT
admet-275	161	28	sorafenib	sorafenib	NOUN
admet-275	161	29	demonstrate	demonstrate	VERB
admet-275	161	30	little	little	ADJ
admet-275	161	31	to	to	ADP
admet-275	161	32	no	no	DET
admet-275	161	33	change	change	NOUN
admet-275	161	34	in	in	ADP
admet-275	161	35	accumulation	accumulation	NOUN
admet-275	161	36	erlotinib	erlotinib	NOUN
admet-275	161	37	gefitinib	gefitinib	NOUN
admet-275	161	38	sorafenib	sorafenib	VERB
admet-275	161	39	sunitinib	sunitinib	PROPN
admet-275	161	40	dasatinib	dasatinib	NOUN
admet-275	161	41	crizotinib	crizotinib	VERB
admet-275	161	42	0	0	NUM
admet-275	161	43	100	100	NUM
admet-275	161	44	200	200	NUM
admet-275	161	45	300	300	NUM
admet-275	161	46	400	400	NUM
admet-275	161	47	verapamil	verapamil	NOUN
admet-275	161	48	desipramine	desipramine	NOUN
admet-275	161	49	cimetidine	cimetidine	PROPN
admet-275	161	50	ß	ß	PROPN
admet-275	161	51	-	-	NOUN
admet-275	161	52	estradiol	estradiol	NOUN
admet-275	161	53	amantadine	amantadine	NOUN
admet-275	161	54	r	r	NOUN
admet-275	161	55	e	e	X
admet-275	161	56	la	la	X
admet-275	161	57	ti	ti	X
admet-275	161	58	v	v	ADP
admet-275	161	59	e	e	PROPN
admet-275	161	60	a	a	DET
admet-275	161	61	c	c	NOUN
admet-275	161	62	c	c	NOUN
admet-275	161	63	u	u	NOUN
admet-275	161	64	m	m	VERB
admet-275	161	65	u	u	NOUN
admet-275	161	66	la	la	X
admet-275	161	67	ti	ti	X
admet-275	161	68	o	o	NOUN
admet-275	162	1	n	n	PROPN
admet-275	163	1	(	(	PUNCT
admet-275	163	2	%	%	INTJ
admet-275	163	3	o	o	X
admet-275	164	1	f	f	X
admet-275	164	2	c	c	NOUN
admet-275	164	3	o	o	X
admet-275	164	4	n	n	PRON
admet-275	164	5	tr	tr	NOUN
admet-275	164	6	o	o	PROPN
admet-275	164	7	l	l	NOUN
admet-275	164	8	)	)	PUNCT
admet-275	165	1	a	a	DET
admet-275	165	2	f	f	NOUN
admet-275	165	3	d	d	X
admet-275	165	4	b	b	PROPN
admet-275	165	5	e	e	X
admet-275	165	6	c	c	PROPN
admet-275	165	7	honeywell	honeywell	VERB
admet-275	165	8	et	et	PROPN
admet-275	165	9	al	al	PROPN
admet-275	165	10	.	.	PROPN
admet-275	165	11	admet	admet	PROPN
admet-275	165	12	&	&	CCONJ
admet-275	165	13	dmpk	dmpk	PROPN
admet-275	165	14	4(1	4(1	NOUN
admet-275	165	15	)	)	PUNCT
admet-275	165	16	(	(	PUNCT
admet-275	165	17	2016	2016	NUM
admet-275	165	18	)	)	PUNCT
admet-275	165	19	23	23	NUM
admet-275	165	20	-	-	SYM
admet-275	165	21	34	34	NUM
admet-275	165	22	30	30	NUM
admet-275	165	23	characteristics	characteristic	NOUN
admet-275	165	24	with	with	ADP
admet-275	165	25	all	all	DET
admet-275	165	26	three	three	NUM
admet-275	165	27	inhibitors	inhibitor	NOUN
admet-275	165	28	.	.	PUNCT
admet-275	166	1	however	however	ADV
admet-275	166	2	,	,	PUNCT
admet-275	166	3	crizotinib	crizotinib	PROPN
admet-275	166	4	’s	’s	PART
admet-275	166	5	permeation	permeation	NOUN
admet-275	166	6	was	be	AUX
admet-275	166	7	increased	increase	VERB
admet-275	166	8	by	by	ADP
admet-275	166	9	desipramine	desipramine	NOUN
admet-275	166	10	and	and	CCONJ
admet-275	166	11	cimetidine	cimetidine	NOUN
admet-275	166	12	unlike	unlike	ADP
admet-275	166	13	sunitinib	sunitinib	NOUN
admet-275	166	14	.	.	PUNCT
admet-275	167	1	desipramine	desipramine	NOUN
admet-275	167	2	decreased	decrease	VERB
admet-275	167	3	cellular	cellular	ADJ
admet-275	167	4	dasatinib	dasatinib	NOUN
admet-275	167	5	accumulation	accumulation	NOUN
admet-275	167	6	in	in	ADP
admet-275	167	7	the	the	DET
admet-275	167	8	transwell	transwell	NOUN
admet-275	167	9	system	system	NOUN
admet-275	167	10	while	while	SCONJ
admet-275	167	11	verapamil	verapamil	NOUN
admet-275	167	12	increased	increase	VERB
admet-275	167	13	it	it	PRON
admet-275	167	14	,	,	PUNCT
admet-275	167	15	cimetidine	cimetidine	PROPN
admet-275	167	16	had	have	VERB
admet-275	167	17	no	no	DET
admet-275	167	18	effect	effect	NOUN
admet-275	167	19	.	.	PUNCT
admet-275	168	1	erlotinib	erlotinib	NOUN
admet-275	168	2	gefitinib	gefitinib	NOUN
admet-275	168	3	sorafenib	sorafenib	VERB
admet-275	168	4	sunitinib	sunitinib	PROPN
admet-275	168	5	dasatinib	dasatinib	NOUN
admet-275	168	6	crizotinib	crizotinib	VERB
admet-275	168	7	0	0	NUM
admet-275	168	8	50	50	NUM
admet-275	168	9	100	100	NUM
admet-275	168	10	150	150	NUM
admet-275	168	11	1000	1000	NUM
admet-275	168	12	2000	2000	NUM
admet-275	168	13	3000	3000	NUM
admet-275	168	14	4000	4000	NUM
admet-275	168	15	5000	5000	NUM
admet-275	168	16	6000	6000	NUM
admet-275	168	17	7000	7000	NUM
admet-275	168	18	8000	8000	NUM
admet-275	168	19	9000	9000	NUM
admet-275	168	20	10000	10000	NUM
admet-275	168	21	11000	11000	NUM
admet-275	168	22	12000	12000	NUM
admet-275	168	23	13000	13000	NUM
admet-275	168	24	control	control	NOUN
admet-275	168	25	verapamil	verapamil	NOUN
admet-275	168	26	desipramine	desipramine	NOUN
admet-275	168	27	cimetidine	cimetidine	NOUN
admet-275	169	1	m	m	VERB
admet-275	169	2	o	o	NOUN
admet-275	169	3	n	n	X
admet-275	169	4	o	o	X
admet-275	169	5	la	la	X
admet-275	169	6	y	y	PROPN
admet-275	170	1	e	e	PROPN
admet-275	170	2	r	r	NOUN
admet-275	170	3	a	a	DET
admet-275	170	4	c	c	NOUN
admet-275	170	5	c	c	NOUN
admet-275	170	6	u	u	NOUN
admet-275	170	7	m	m	VERB
admet-275	170	8	u	u	NOUN
admet-275	170	9	la	la	X
admet-275	170	10	ti	ti	X
admet-275	170	11	o	o	NOUN
admet-275	170	12	n	n	PROPN
admet-275	170	13	(	(	PUNCT
admet-275	170	14	n	n	CCONJ
admet-275	170	15	g	g	PROPN
admet-275	170	16	d	d	PROPN
admet-275	170	17	ru	ru	PROPN
admet-275	170	18	g	g	PROPN
admet-275	170	19	/	/	SYM
admet-275	170	20	m	m	PROPN
admet-275	170	21	g	g	NOUN
admet-275	170	22	p	p	X
admet-275	170	23	ro	ro	X
admet-275	170	24	te	te	INTJ
admet-275	170	25	in	in	ADP
admet-275	170	26	)	)	PUNCT
admet-275	170	27	figure	figure	NOUN
admet-275	170	28	5	5	NUM
admet-275	170	29	.	.	PUNCT
admet-275	171	1	following	follow	VERB
admet-275	171	2	the	the	DET
admet-275	171	3	3	3	NUM
admet-275	171	4	hour	hour	NOUN
admet-275	171	5	exposure	exposure	NOUN
admet-275	171	6	of	of	ADP
admet-275	171	7	the	the	DET
admet-275	171	8	monolayer	monolayer	NOUN
admet-275	171	9	to	to	PART
admet-275	171	10	erlotinib	erlotinib	VERB
admet-275	171	11	,	,	PUNCT
admet-275	171	12	gefitinib	gefitinib	NOUN
admet-275	171	13	,	,	PUNCT
admet-275	171	14	sunitinib	sunitinib	NOUN
admet-275	171	15	and	and	CCONJ
admet-275	171	16	sorafenib	sorafenib	NOUN
admet-275	171	17	,	,	PUNCT
admet-275	171	18	crizotinib	crizotinib	VERB
admet-275	171	19	and	and	CCONJ
admet-275	171	20	dasatinib	dasatinib	VERB
admet-275	171	21	the	the	DET
admet-275	171	22	cells	cell	NOUN
admet-275	171	23	were	be	AUX
admet-275	171	24	harvested	harvest	VERB
admet-275	171	25	and	and	CCONJ
admet-275	171	26	analysed	analyse	VERB
admet-275	171	27	for	for	ADP
admet-275	171	28	tki	tki	NOUN
admet-275	171	29	accumulation	accumulation	NOUN
admet-275	171	30	.	.	PUNCT
admet-275	172	1	exposure	exposure	NOUN
admet-275	172	2	was	be	AUX
admet-275	172	3	determined	determine	VERB
admet-275	172	4	both	both	CCONJ
admet-275	172	5	with	with	ADP
admet-275	172	6	and	and	CCONJ
admet-275	172	7	without	without	ADP
admet-275	172	8	the	the	DET
admet-275	172	9	addition	addition	NOUN
admet-275	172	10	of	of	ADP
admet-275	172	11	10	10	NUM
admet-275	172	12	μm	μm	NOUN
admet-275	172	13	verapamil	verapamil	NOUN
admet-275	172	14	,	,	PUNCT
admet-275	172	15	100	100	NUM
admet-275	172	16	μm	μm	NOUN
admet-275	172	17	desipramine	desipramine	NOUN
admet-275	172	18	or	or	CCONJ
admet-275	172	19	100	100	NUM
admet-275	172	20	µm	µm	ADP
admet-275	172	21	cimetidine	cimetidine	NOUN
admet-275	172	22	.	.	PUNCT
admet-275	173	1	values	value	NOUN
admet-275	173	2	presented	present	VERB
admet-275	173	3	are	be	AUX
admet-275	173	4	from	from	ADP
admet-275	173	5	one	one	NUM
admet-275	173	6	representative	representative	ADJ
admet-275	173	7	experiment	experiment	NOUN
admet-275	173	8	.	.	PUNCT
admet-275	174	1	cellular	cellular	ADJ
admet-275	174	2	accumulation	accumulation	NOUN
admet-275	174	3	was	be	AUX
admet-275	174	4	normalized	normalize	VERB
admet-275	174	5	to	to	PART
admet-275	174	6	cell	cell	VERB
admet-275	174	7	protein	protein	NOUN
admet-275	174	8	amount	amount	NOUN
admet-275	174	9	.	.	PUNCT
admet-275	175	1	discussion	discussion	NOUN
admet-275	175	2	this	this	DET
admet-275	175	3	study	study	NOUN
admet-275	175	4	demonstrated	demonstrate	VERB
admet-275	175	5	that	that	SCONJ
admet-275	175	6	tkis	tkis	NOUN
admet-275	175	7	can	can	AUX
admet-275	175	8	be	be	AUX
admet-275	175	9	transported	transport	VERB
admet-275	175	10	,	,	PUNCT
admet-275	175	11	either	either	CCONJ
admet-275	175	12	passively	passively	ADV
admet-275	175	13	or	or	CCONJ
admet-275	175	14	by	by	ADP
admet-275	175	15	an	an	DET
admet-275	175	16	active	active	ADJ
admet-275	175	17	process	process	NOUN
admet-275	175	18	;	;	PUNCT
admet-275	175	19	for	for	SCONJ
admet-275	175	20	the	the	DET
admet-275	175	21	latter	latter	ADJ
admet-275	175	22	both	both	PRON
admet-275	175	23	influx	influx	VERB
admet-275	175	24	and	and	CCONJ
admet-275	175	25	efflux	efflux	VERB
admet-275	175	26	transporters	transporter	NOUN
admet-275	175	27	are	be	AUX
admet-275	175	28	involved	involve	VERB
admet-275	175	29	.	.	PUNCT
admet-275	176	1	caco-2	caco-2	NUM
admet-275	176	2	cells	cell	NOUN
admet-275	176	3	were	be	AUX
admet-275	176	4	used	use	VERB
admet-275	176	5	by	by	ADP
admet-275	176	6	two	two	NUM
admet-275	176	7	different	different	ADJ
admet-275	176	8	approaches	approach	NOUN
admet-275	176	9	,	,	PUNCT
admet-275	176	10	as	as	ADP
admet-275	176	11	a	a	DET
admet-275	176	12	colon	colon	NOUN
admet-275	176	13	cancer	cancer	NOUN
admet-275	176	14	cell	cell	NOUN
admet-275	176	15	line	line	NOUN
admet-275	176	16	to	to	PART
admet-275	176	17	determine	determine	VERB
admet-275	176	18	the	the	DET
admet-275	176	19	passive	passive	ADJ
admet-275	176	20	and	and	CCONJ
admet-275	176	21	active	active	ADJ
admet-275	176	22	accumulation	accumulation	NOUN
admet-275	176	23	of	of	ADP
admet-275	176	24	tki	tki	NOUN
admet-275	176	25	in	in	ADP
admet-275	176	26	the	the	DET
admet-275	176	27	cells	cell	NOUN
admet-275	176	28	and	and	CCONJ
admet-275	176	29	as	as	ADP
admet-275	176	30	a	a	DET
admet-275	176	31	model	model	NOUN
admet-275	176	32	for	for	ADP
admet-275	176	33	intestinal	intestinal	ADJ
admet-275	176	34	epithelium	epithelium	NOUN
admet-275	176	35	using	use	VERB
admet-275	176	36	a	a	DET
admet-275	176	37	transwell	transwell	NOUN
admet-275	176	38	system	system	NOUN
admet-275	176	39	as	as	SCONJ
admet-275	176	40	described	describe	VERB
admet-275	176	41	earlier	early	ADV
admet-275	176	42	[	[	X
admet-275	176	43	33	33	NUM
admet-275	176	44	]	]	PUNCT
admet-275	176	45	.	.	PUNCT
admet-275	177	1	the	the	DET
admet-275	177	2	temperature	temperature	NOUN
admet-275	177	3	study	study	NOUN
admet-275	177	4	demonstrated	demonstrate	VERB
admet-275	177	5	that	that	SCONJ
admet-275	177	6	uptake	uptake	NOUN
admet-275	177	7	of	of	ADP
admet-275	177	8	crizotinib	crizotinib	NOUN
admet-275	177	9	,	,	PUNCT
admet-275	177	10	sorafenib	sorafenib	NOUN
admet-275	177	11	and	and	CCONJ
admet-275	177	12	sunitinib	sunitinib	NOUN
admet-275	177	13	seems	seem	VERB
admet-275	177	14	to	to	PART
admet-275	177	15	be	be	AUX
admet-275	177	16	a	a	DET
admet-275	177	17	passive	passive	ADJ
admet-275	177	18	process	process	NOUN
admet-275	177	19	,	,	PUNCT
admet-275	177	20	but	but	CCONJ
admet-275	177	21	that	that	PRON
admet-275	177	22	of	of	ADP
admet-275	177	23	sunitinib	sunitinib	NOUN
admet-275	177	24	,	,	PUNCT
admet-275	177	25	crizotinib	crizotinib	VERB
admet-275	177	26	and	and	CCONJ
admet-275	177	27	sorafenb	sorafenb	NOUN
admet-275	177	28	seems	seem	VERB
admet-275	177	29	to	to	PART
admet-275	177	30	be	be	AUX
admet-275	177	31	passive	passive	ADJ
admet-275	177	32	.	.	PUNCT
admet-275	178	1	galetti	galetti	NOUN
admet-275	178	2	et	et	PROPN
admet-275	178	3	al	al	PROPN
admet-275	178	4	.	.	PUNCT
admet-275	179	1	[	[	X
admet-275	179	2	41	41	NUM
admet-275	179	3	]	]	PUNCT
admet-275	179	4	also	also	ADV
admet-275	179	5	studied	study	VERB
admet-275	179	6	temperature	temperature	NOUN
admet-275	179	7	dependency	dependency	NOUN
admet-275	179	8	of	of	ADP
admet-275	179	9	gefitnib	gefitnib	NOUN
admet-275	179	10	at	at	ADP
admet-275	179	11	4	4	NUM
admet-275	179	12	°	°	ADP
admet-275	179	13	c	c	NOUN
admet-275	179	14	and	and	CCONJ
admet-275	179	15	37	37	NUM
admet-275	179	16	°	°	NOUN
admet-275	179	17	c	c	NOUN
admet-275	179	18	,	,	PUNCT
admet-275	179	19	but	but	CCONJ
admet-275	179	20	over	over	ADP
admet-275	179	21	a	a	DET
admet-275	179	22	limited	limited	ADJ
admet-275	179	23	time	time	NOUN
admet-275	179	24	period	period	NOUN
admet-275	179	25	of	of	ADP
admet-275	179	26	sixty	sixty	NUM
admet-275	179	27	minutes	minute	NOUN
admet-275	179	28	with	with	ADP
admet-275	179	29	multiple	multiple	ADJ
admet-275	179	30	points	point	NOUN
admet-275	179	31	,	,	PUNCT
admet-275	179	32	showing	show	VERB
admet-275	179	33	a	a	DET
admet-275	179	34	clear	clear	ADJ
admet-275	179	35	difference	difference	NOUN
admet-275	179	36	.	.	PUNCT
admet-275	180	1	next	next	ADJ
admet-275	180	2	to	to	ADP
admet-275	180	3	gefitinib	gefitinib	NOUN
admet-275	180	4	,	,	PUNCT
admet-275	180	5	dasatinib	dasatinib	NOUN
admet-275	180	6	uptake	uptake	ADJ
admet-275	180	7	seemed	seem	VERB
admet-275	180	8	to	to	PART
admet-275	180	9	be	be	AUX
admet-275	180	10	predominantly	predominantly	ADV
admet-275	180	11	an	an	DET
admet-275	180	12	active	active	ADJ
admet-275	180	13	process	process	NOUN
admet-275	180	14	.	.	PUNCT
admet-275	181	1	however	however	ADV
admet-275	181	2	,	,	PUNCT
admet-275	181	3	giannoudis	giannoudis	VERB
admet-275	181	4	et	et	NOUN
admet-275	181	5	al	al	PROPN
admet-275	181	6	.	.	PUNCT
admet-275	182	1	[	[	X
admet-275	182	2	42	42	NUM
admet-275	182	3	]	]	PUNCT
admet-275	182	4	postulated	postulate	VERB
admet-275	182	5	that	that	SCONJ
admet-275	182	6	the	the	DET
admet-275	182	7	uptake	uptake	NOUN
admet-275	182	8	is	be	AUX
admet-275	182	9	likely	likely	ADV
admet-275	182	10	passive	passive	ADJ
admet-275	182	11	diffusion	diffusion	NOUN
admet-275	182	12	because	because	SCONJ
admet-275	182	13	of	of	ADP
admet-275	182	14	the	the	DET
admet-275	182	15	lipophilic	lipophilic	ADJ
admet-275	182	16	properties	property	NOUN
admet-275	182	17	of	of	ADP
admet-275	182	18	dasatinib	dasatinib	NOUN
admet-275	182	19	.	.	PUNCT
admet-275	183	1	on	on	ADP
admet-275	183	2	the	the	DET
admet-275	183	3	other	other	ADJ
admet-275	183	4	hand	hand	NOUN
admet-275	183	5	,	,	PUNCT
admet-275	183	6	they	they	PRON
admet-275	183	7	state	state	VERB
admet-275	183	8	that	that	SCONJ
admet-275	183	9	the	the	DET
admet-275	183	10	role	role	NOUN
admet-275	183	11	of	of	ADP
admet-275	183	12	other	other	ADJ
admet-275	183	13	uptake	uptake	ADJ
admet-275	183	14	transporters	transporter	NOUN
admet-275	183	15	could	could	AUX
admet-275	183	16	not	not	PART
admet-275	183	17	be	be	AUX
admet-275	183	18	excluded	exclude	VERB
admet-275	183	19	[	[	PUNCT
admet-275	183	20	43	43	NUM
admet-275	183	21	]	]	PUNCT
admet-275	183	22	.	.	PUNCT
admet-275	184	1	in	in	ADP
admet-275	184	2	our	our	PRON
admet-275	184	3	hands	hand	NOUN
admet-275	184	4	there	there	PRON
admet-275	184	5	is	be	VERB
admet-275	184	6	a	a	DET
admet-275	184	7	clear	clear	ADJ
admet-275	184	8	difference	difference	NOUN
admet-275	184	9	between	between	ADP
admet-275	184	10	4	4	NUM
admet-275	184	11	°	°	NOUN
admet-275	184	12	c	c	NOUN
admet-275	184	13	and	and	CCONJ
admet-275	184	14	37	37	NUM
admet-275	184	15	°	°	NOUN
admet-275	184	16	c	c	NOUN
admet-275	184	17	,	,	PUNCT
admet-275	184	18	indicating	indicate	VERB
admet-275	184	19	an	an	DET
admet-275	184	20	active	active	ADJ
admet-275	184	21	transport	transport	NOUN
admet-275	184	22	.	.	PUNCT
admet-275	185	1	hu	hu	PROPN
admet-275	185	2	et	et	PROPN
admet-275	185	3	al	al	PROPN
admet-275	185	4	.	.	PUNCT
admet-275	186	1	[	[	X
admet-275	186	2	44	44	NUM
admet-275	186	3	]	]	PUNCT
admet-275	186	4	already	already	ADV
admet-275	186	5	reported	report	VERB
admet-275	186	6	that	that	SCONJ
admet-275	186	7	both	both	DET
admet-275	186	8	sunitinib	sunitinib	NOUN
admet-275	186	9	and	and	CCONJ
admet-275	186	10	sorafenib	sorafenib	NOUN
admet-275	186	11	do	do	AUX
admet-275	186	12	not	not	PART
admet-275	186	13	appear	appear	VERB
admet-275	186	14	to	to	PART
admet-275	186	15	rely	rely	VERB
admet-275	186	16	on	on	ADP
admet-275	186	17	active	active	ADJ
admet-275	186	18	transport	transport	NOUN
admet-275	186	19	to	to	PART
admet-275	186	20	enter	enter	VERB
admet-275	186	21	the	the	DET
admet-275	186	22	cell	cell	NOUN
admet-275	186	23	.	.	PUNCT
admet-275	187	1	these	these	DET
admet-275	187	2	drugs	drug	NOUN
admet-275	187	3	are	be	AUX
admet-275	187	4	also	also	ADV
admet-275	187	5	not	not	PART
admet-275	187	6	a	a	DET
admet-275	187	7	high	high	ADJ
admet-275	187	8	affinity	affinity	NOUN
admet-275	187	9	substrate	substrate	NOUN
admet-275	187	10	for	for	ADP
admet-275	187	11	the	the	DET
admet-275	187	12	abcfamily	abcfamily	ADJ
admet-275	187	13	transporters	transporter	NOUN
admet-275	187	14	,	,	PUNCT
admet-275	187	15	which	which	PRON
admet-275	187	16	is	be	AUX
admet-275	187	17	in	in	ADP
admet-275	187	18	agreement	agreement	NOUN
admet-275	187	19	with	with	ADP
admet-275	187	20	the	the	DET
admet-275	187	21	data	datum	NOUN
admet-275	187	22	reported	report	VERB
admet-275	187	23	by	by	ADP
admet-275	187	24	this	this	DET
admet-275	187	25	study	study	NOUN
admet-275	187	26	.	.	PUNCT
admet-275	188	1	however	however	ADV
admet-275	188	2	,	,	PUNCT
admet-275	188	3	passive	passive	ADJ
admet-275	188	4	transport	transport	NOUN
admet-275	188	5	can	can	AUX
admet-275	188	6	be	be	AUX
admet-275	188	7	masked	mask	VERB
admet-275	188	8	by	by	ADP
admet-275	188	9	the	the	DET
admet-275	188	10	lysosomal	lysosomal	ADJ
admet-275	188	11	uptake	uptake	NOUN
admet-275	188	12	leading	lead	VERB
admet-275	188	13	to	to	ADP
admet-275	188	14	more	more	ADJ
admet-275	188	15	accumulation	accumulation	NOUN
admet-275	188	16	in	in	ADP
admet-275	188	17	the	the	DET
admet-275	188	18	cell	cell	NOUN
admet-275	188	19	at	at	ADP
admet-275	188	20	37	37	NUM
admet-275	188	21	°	°	ADP
admet-275	188	22	c	c	NOUN
admet-275	188	23	as	as	SCONJ
admet-275	188	24	seen	see	VERB
admet-275	188	25	with	with	ADP
admet-275	188	26	sunitinib	sunitinib	NOUN
admet-275	189	1	[	[	X
admet-275	189	2	22,39	22,39	NUM
admet-275	189	3	]	]	PUNCT
admet-275	189	4	.	.	PUNCT
admet-275	190	1	admet	admet	PROPN
admet-275	190	2	&	&	CCONJ
admet-275	190	3	dmpk	dmpk	PROPN
admet-275	190	4	4(1	4(1	NOUN
admet-275	190	5	)	)	PUNCT
admet-275	190	6	(	(	PUNCT
admet-275	190	7	2016	2016	NUM
admet-275	190	8	)	)	PUNCT
admet-275	190	9	23	23	NUM
admet-275	190	10	-	-	SYM
admet-275	190	11	34	34	NUM
admet-275	190	12	transport	transport	NOUN
admet-275	190	13	mechanism	mechanism	NOUN
admet-275	190	14	of	of	ADP
admet-275	190	15	tk	tk	PROPN
admet-275	190	16	inhibitors	inhibitor	NOUN
admet-275	190	17	doi	doi	NOUN
admet-275	190	18	:	:	PUNCT
admet-275	190	19	10.5599	10.5599	NUM
admet-275	190	20	/	/	SYM
admet-275	190	21	admet.4.1.275	admet.4.1.275	PROPN
admet-275	190	22	31	31	NUM
admet-275	190	23	cationic	cationic	ADJ
admet-275	190	24	charge	charge	NOUN
admet-275	190	25	and	and	CCONJ
admet-275	190	26	high	high	ADJ
admet-275	190	27	lipophilicity	lipophilicity	NOUN
admet-275	190	28	are	be	AUX
admet-275	190	29	requirements	requirement	NOUN
admet-275	190	30	of	of	ADP
admet-275	190	31	oct	oct	PROPN
admet-275	190	32	dependent	dependent	ADJ
admet-275	190	33	transport	transport	NOUN
admet-275	190	34	of	of	ADP
admet-275	190	35	drugs	drug	NOUN
admet-275	190	36	[	[	X
admet-275	190	37	28	28	NUM
admet-275	190	38	]	]	PUNCT
admet-275	190	39	.	.	PUNCT
admet-275	191	1	thomas	thomas	PROPN
admet-275	191	2	et	et	PROPN
admet-275	191	3	al	al	PROPN
admet-275	191	4	.	.	PUNCT
admet-275	192	1	[	[	X
admet-275	192	2	27	27	NUM
admet-275	192	3	]	]	PUNCT
admet-275	192	4	already	already	ADV
admet-275	192	5	indicated	indicate	VERB
admet-275	192	6	the	the	DET
admet-275	192	7	involvement	involvement	NOUN
admet-275	192	8	of	of	ADP
admet-275	192	9	the	the	DET
admet-275	192	10	human	human	ADJ
admet-275	192	11	hoct1	hoct1	NOUN
admet-275	192	12	in	in	ADP
admet-275	192	13	the	the	DET
admet-275	192	14	active	active	ADJ
admet-275	192	15	uptake	uptake	NOUN
admet-275	192	16	of	of	ADP
admet-275	192	17	imatinib	imatinib	NOUN
admet-275	192	18	.	.	PUNCT
admet-275	193	1	however	however	ADV
admet-275	193	2	,	,	PUNCT
admet-275	193	3	since	since	SCONJ
admet-275	193	4	several	several	ADJ
admet-275	193	5	of	of	ADP
admet-275	193	6	the	the	DET
admet-275	193	7	six	six	NUM
admet-275	193	8	tkis	tkis	NOUN
admet-275	193	9	(	(	PUNCT
admet-275	193	10	gefitinib	gefitinib	NOUN
admet-275	193	11	,	,	PUNCT
admet-275	193	12	sunitinib	sunitinib	NOUN
admet-275	193	13	and	and	CCONJ
admet-275	193	14	dasatinib	dasatinib	NOUN
admet-275	193	15	)	)	PUNCT
admet-275	193	16	are	be	AUX
admet-275	193	17	positively	positively	ADV
admet-275	193	18	charged	charge	VERB
admet-275	193	19	[	[	PUNCT
admet-275	193	20	22	22	NUM
admet-275	193	21	]	]	PUNCT
admet-275	193	22	and	and	CCONJ
admet-275	193	23	all	all	PRON
admet-275	193	24	of	of	ADP
admet-275	193	25	the	the	DET
admet-275	193	26	six	six	NUM
admet-275	193	27	tkis	tkis	NOUN
admet-275	193	28	have	have	VERB
admet-275	193	29	high	high	ADJ
admet-275	193	30	lipophilic	lipophilic	ADJ
admet-275	193	31	properties	property	NOUN
admet-275	193	32	,	,	PUNCT
admet-275	193	33	we	we	PRON
admet-275	193	34	hypothesized	hypothesize	VERB
admet-275	193	35	that	that	SCONJ
admet-275	193	36	some	some	PRON
admet-275	193	37	of	of	ADP
admet-275	193	38	the	the	DET
admet-275	193	39	tkis	tkis	NOUN
admet-275	193	40	are	be	AUX
admet-275	193	41	(	(	PUNCT
admet-275	193	42	partly	partly	ADV
admet-275	193	43	)	)	PUNCT
admet-275	193	44	dependent	dependent	ADJ
admet-275	193	45	on	on	ADP
admet-275	193	46	hoct	hoct	PROPN
admet-275	193	47	uptake	uptake	ADJ
admet-275	193	48	.	.	PUNCT
admet-275	194	1	the	the	DET
admet-275	194	2	results	result	NOUN
admet-275	194	3	indicate	indicate	VERB
admet-275	194	4	that	that	SCONJ
admet-275	194	5	the	the	DET
admet-275	194	6	relative	relative	ADJ
admet-275	194	7	accumulation	accumulation	NOUN
admet-275	194	8	decreased	decrease	VERB
admet-275	194	9	for	for	ADP
admet-275	194	10	all	all	DET
admet-275	194	11	tkis	tkis	NOUN
admet-275	194	12	after	after	ADP
admet-275	194	13	the	the	DET
admet-275	194	14	addition	addition	NOUN
admet-275	194	15	of	of	ADP
admet-275	194	16	one	one	NUM
admet-275	194	17	or	or	CCONJ
admet-275	194	18	more	more	ADJ
admet-275	194	19	of	of	ADP
admet-275	194	20	the	the	DET
admet-275	194	21	hoct	hoct	NOUN
admet-275	194	22	inhibitors	inhibitor	NOUN
admet-275	194	23	except	except	SCONJ
admet-275	194	24	for	for	ADP
admet-275	194	25	erlotinib	erlotinib	NOUN
admet-275	194	26	.	.	PUNCT
admet-275	195	1	both	both	PRON
admet-275	195	2	erlotinib	erlotinib	NOUN
admet-275	195	3	and	and	CCONJ
admet-275	195	4	dasatinib	dasatinib	NOUN
admet-275	195	5	showed	show	VERB
admet-275	195	6	high	high	ADJ
admet-275	195	7	relative	relative	ADJ
admet-275	195	8	accumulation	accumulation	NOUN
admet-275	195	9	after	after	ADP
admet-275	195	10	incubation	incubation	NOUN
admet-275	195	11	with	with	ADP
admet-275	195	12	verapamil	verapamil	NOUN
admet-275	195	13	.	.	PUNCT
admet-275	196	1	this	this	PRON
admet-275	196	2	is	be	AUX
admet-275	196	3	probably	probably	ADV
admet-275	196	4	due	due	ADJ
admet-275	196	5	to	to	ADP
admet-275	196	6	the	the	DET
admet-275	196	7	inhibition	inhibition	NOUN
admet-275	196	8	of	of	ADP
admet-275	196	9	p	p	NOUN
admet-275	196	10	-	-	PUNCT
admet-275	196	11	gp	gp	NOUN
admet-275	196	12	,	,	PUNCT
admet-275	196	13	also	also	ADV
admet-275	196	14	induced	induce	VERB
admet-275	196	15	by	by	ADP
admet-275	196	16	verapamil	verapamil	NOUN
admet-275	196	17	.	.	PUNCT
admet-275	197	1	de	de	PROPN
admet-275	197	2	vries	vries	PROPN
admet-275	197	3	et	et	NOUN
admet-275	197	4	al	al	PROPN
admet-275	197	5	.	.	PUNCT
admet-275	198	1	[	[	X
admet-275	198	2	45	45	NUM
admet-275	198	3	]	]	PUNCT
admet-275	198	4	also	also	ADV
admet-275	198	5	suggested	suggest	VERB
admet-275	198	6	the	the	DET
admet-275	198	7	involvement	involvement	NOUN
admet-275	198	8	of	of	ADP
admet-275	198	9	p	p	NOUN
admet-275	198	10	-	-	PUNCT
admet-275	198	11	gp	gp	NOUN
admet-275	198	12	in	in	ADP
admet-275	198	13	the	the	DET
admet-275	198	14	efflux	efflux	NOUN
admet-275	198	15	of	of	ADP
admet-275	198	16	erlotinib	erlotinib	NOUN
admet-275	198	17	.	.	PUNCT
admet-275	199	1	giannoudis	giannoudis	VERB
admet-275	199	2	et	et	NOUN
admet-275	199	3	al	al	PROPN
admet-275	199	4	.	.	PUNCT
admet-275	200	1	[	[	X
admet-275	200	2	42	42	NUM
admet-275	200	3	]	]	PUNCT
admet-275	200	4	and	and	CCONJ
admet-275	200	5	gromicho	gromicho	NOUN
admet-275	200	6	et	et	PROPN
admet-275	200	7	al	al	PROPN
admet-275	200	8	.	.	PUNCT
admet-275	201	1	[	[	X
admet-275	201	2	43	43	NUM
admet-275	201	3	]	]	PUNCT
admet-275	201	4	suggested	suggest	VERB
admet-275	201	5	that	that	SCONJ
admet-275	201	6	p	p	X
admet-275	201	7	-	-	PUNCT
admet-275	201	8	gp	gp	NOUN
admet-275	201	9	is	be	AUX
admet-275	201	10	also	also	ADV
admet-275	201	11	involved	involve	VERB
admet-275	201	12	in	in	ADP
admet-275	201	13	dasatinib	dasatinib	NOUN
admet-275	201	14	dependent	dependent	ADJ
admet-275	201	15	efflux	efflux	NOUN
admet-275	201	16	.	.	PUNCT
admet-275	202	1	the	the	DET
admet-275	202	2	effect	effect	NOUN
admet-275	202	3	of	of	ADP
admet-275	202	4	hoct	hoct	NOUN
admet-275	202	5	inhibitors	inhibitor	NOUN
admet-275	202	6	on	on	ADP
admet-275	202	7	sunitinib	sunitinib	NOUN
admet-275	202	8	and	and	CCONJ
admet-275	202	9	crizotinib	crizotinib	NOUN
admet-275	202	10	was	be	AUX
admet-275	202	11	similar	similar	ADJ
admet-275	202	12	,	,	PUNCT
admet-275	202	13	except	except	SCONJ
admet-275	202	14	for	for	ADP
admet-275	202	15	verapamil	verapamil	NOUN
admet-275	202	16	.	.	PUNCT
admet-275	203	1	both	both	PRON
admet-275	203	2	desipramine	desipramine	NOUN
admet-275	203	3	and	and	CCONJ
admet-275	203	4	cimetidine	cimetidine	NOUN
admet-275	203	5	inhibit	inhibit	VERB
admet-275	203	6	all	all	DET
admet-275	203	7	three	three	NUM
admet-275	203	8	hocts	hoct	NOUN
admet-275	203	9	.	.	PUNCT
admet-275	204	1	for	for	ADP
admet-275	204	2	most	most	ADJ
admet-275	204	3	of	of	ADP
admet-275	204	4	the	the	DET
admet-275	204	5	tkis	tkis	NOUN
admet-275	204	6	,	,	PUNCT
admet-275	204	7	desipramine	desipramine	NOUN
admet-275	204	8	induced	induce	VERB
admet-275	204	9	the	the	DET
admet-275	204	10	highest	high	ADJ
admet-275	204	11	decrease	decrease	NOUN
admet-275	204	12	of	of	ADP
admet-275	204	13	relative	relative	ADJ
admet-275	204	14	accumulation	accumulation	NOUN
admet-275	204	15	.	.	PUNCT
admet-275	205	1	the	the	DET
admet-275	205	2	different	different	ADJ
admet-275	205	3	effects	effect	NOUN
admet-275	205	4	of	of	ADP
admet-275	205	5	cimetidine	cimetidine	NOUN
admet-275	205	6	and	and	CCONJ
admet-275	205	7	desipramine	desipramine	NOUN
admet-275	205	8	,	,	PUNCT
admet-275	205	9	despite	despite	SCONJ
admet-275	205	10	their	their	PRON
admet-275	205	11	same	same	ADJ
admet-275	205	12	inhibitor	inhibitor	NOUN
admet-275	205	13	function	function	NOUN
admet-275	205	14	of	of	ADP
admet-275	205	15	hoct	hoct	NOUN
admet-275	205	16	,	,	PUNCT
admet-275	205	17	might	might	AUX
admet-275	205	18	be	be	AUX
admet-275	205	19	due	due	ADJ
admet-275	205	20	to	to	ADP
admet-275	205	21	concentration	concentration	NOUN
admet-275	205	22	effects	effect	NOUN
admet-275	205	23	.	.	PUNCT
admet-275	206	1	some	some	DET
admet-275	206	2	hoct	hoct	NOUN
admet-275	206	3	inhibitors	inhibitor	NOUN
admet-275	206	4	can	can	AUX
admet-275	206	5	be	be	AUX
admet-275	206	6	less	less	ADV
admet-275	206	7	effective	effective	ADJ
admet-275	206	8	at	at	ADP
admet-275	206	9	certain	certain	ADJ
admet-275	206	10	concentrations	concentration	NOUN
admet-275	206	11	.	.	PUNCT
admet-275	207	1	only	only	ADV
admet-275	207	2	cimetidine	cimetidine	NOUN
admet-275	207	3	and	and	CCONJ
admet-275	207	4	desipramine	desipramine	NOUN
admet-275	207	5	decreased	decrease	VERB
admet-275	207	6	the	the	DET
admet-275	207	7	relative	relative	ADJ
admet-275	207	8	accumulation	accumulation	NOUN
admet-275	207	9	of	of	ADP
admet-275	207	10	sorafenib	sorafenib	NOUN
admet-275	207	11	.	.	PUNCT
admet-275	208	1	it	it	PRON
admet-275	208	2	is	be	AUX
admet-275	208	3	possible	possible	ADJ
admet-275	208	4	that	that	SCONJ
admet-275	208	5	all	all	DET
admet-275	208	6	three	three	NUM
admet-275	208	7	hoct	hoct	NOUN
admet-275	208	8	should	should	AUX
admet-275	208	9	be	be	AUX
admet-275	208	10	inhibited	inhibit	VERB
admet-275	208	11	to	to	PART
admet-275	208	12	see	see	VERB
admet-275	208	13	an	an	DET
admet-275	208	14	effect	effect	NOUN
admet-275	208	15	in	in	ADP
admet-275	208	16	relative	relative	ADJ
admet-275	208	17	accumulation	accumulation	NOUN
admet-275	208	18	of	of	ADP
admet-275	208	19	sorafenib	sorafenib	NOUN
admet-275	208	20	,	,	PUNCT
admet-275	208	21	although	although	SCONJ
admet-275	208	22	hu	hu	PROPN
admet-275	208	23	et	et	PROPN
admet-275	208	24	al	al	PROPN
admet-275	208	25	.	.	PUNCT
admet-275	209	1	[	[	X
admet-275	209	2	44	44	NUM
admet-275	209	3	]	]	PUNCT
admet-275	209	4	reported	report	VERB
admet-275	209	5	that	that	SCONJ
admet-275	209	6	sorafenib	sorafenib	NOUN
admet-275	209	7	does	do	AUX
admet-275	209	8	not	not	PART
admet-275	209	9	appear	appear	VERB
admet-275	209	10	to	to	PART
admet-275	209	11	rely	rely	VERB
admet-275	209	12	on	on	ADP
admet-275	209	13	active	active	ADJ
admet-275	209	14	transport	transport	NOUN
admet-275	209	15	to	to	PART
admet-275	209	16	enter	enter	VERB
admet-275	209	17	the	the	DET
admet-275	209	18	cell	cell	NOUN
admet-275	209	19	.	.	PUNCT
admet-275	210	1	nevertheless	nevertheless	ADV
admet-275	210	2	,	,	PUNCT
admet-275	210	3	none	none	NOUN
admet-275	210	4	of	of	ADP
admet-275	210	5	the	the	DET
admet-275	210	6	used	use	VERB
admet-275	210	7	hoct	hoct	NOUN
admet-275	210	8	inhibitors	inhibitor	NOUN
admet-275	210	9	are	be	AUX
admet-275	210	10	specific	specific	ADJ
admet-275	210	11	.	.	PUNCT
admet-275	211	1	therefore	therefore	ADV
admet-275	211	2	it	it	PRON
admet-275	211	3	can	can	AUX
admet-275	211	4	not	not	PART
admet-275	211	5	be	be	AUX
admet-275	211	6	concluded	conclude	VERB
admet-275	211	7	that	that	SCONJ
admet-275	211	8	the	the	DET
admet-275	211	9	tkis	tkis	NOUN
admet-275	211	10	are	be	AUX
admet-275	211	11	exclusively	exclusively	ADV
admet-275	211	12	transported	transport	VERB
admet-275	211	13	by	by	ADP
admet-275	211	14	hoct	hoct	PROPN
admet-275	211	15	.	.	PUNCT
admet-275	212	1	for	for	ADP
admet-275	212	2	a	a	DET
admet-275	212	3	better	well	ADJ
admet-275	212	4	definition	definition	NOUN
admet-275	212	5	of	of	ADP
admet-275	212	6	the	the	DET
admet-275	212	7	role	role	NOUN
admet-275	212	8	of	of	ADP
admet-275	212	9	hoct	hoct	NOUN
admet-275	212	10	transporter	transporter	NOUN
admet-275	212	11	activity	activity	NOUN
admet-275	212	12	in	in	ADP
admet-275	212	13	the	the	DET
admet-275	212	14	transport	transport	NOUN
admet-275	212	15	of	of	ADP
admet-275	212	16	tkis	tkis	NOUN
admet-275	212	17	it	it	PRON
admet-275	212	18	is	be	AUX
admet-275	212	19	recommended	recommend	VERB
admet-275	212	20	to	to	PART
admet-275	212	21	use	use	VERB
admet-275	212	22	more	more	ADV
admet-275	212	23	specific	specific	ADJ
admet-275	212	24	hoct	hoct	NOUN
admet-275	212	25	inhibitors	inhibitor	NOUN
admet-275	212	26	such	such	ADJ
admet-275	212	27	as	as	ADP
admet-275	212	28	sirnas	sirna	NOUN
admet-275	212	29	.	.	PUNCT
admet-275	213	1	in	in	ADP
admet-275	213	2	the	the	DET
admet-275	213	3	caco-2	caco-2	NUM
admet-275	213	4	gut	gut	VERB
admet-275	213	5	epithelial	epithelial	ADJ
admet-275	213	6	model	model	NOUN
admet-275	213	7	system	system	NOUN
admet-275	213	8	permeation	permeation	NOUN
admet-275	213	9	is	be	AUX
admet-275	213	10	a	a	DET
admet-275	213	11	sequential	sequential	ADJ
admet-275	213	12	process	process	NOUN
admet-275	213	13	,	,	PUNCT
admet-275	213	14	consisting	consist	VERB
admet-275	213	15	of	of	ADP
admet-275	213	16	passive	passive	ADJ
admet-275	213	17	or	or	CCONJ
admet-275	213	18	active	active	ADJ
admet-275	213	19	membrane	membrane	NOUN
admet-275	213	20	transport	transport	NOUN
admet-275	213	21	at	at	ADP
admet-275	213	22	the	the	DET
admet-275	213	23	apical	apical	ADJ
admet-275	213	24	site	site	NOUN
admet-275	213	25	,	,	PUNCT
admet-275	213	26	possible	possible	ADJ
admet-275	213	27	trapping	trap	VERB
admet-275	213	28	in	in	ADP
admet-275	213	29	the	the	DET
admet-275	213	30	cell	cell	NOUN
admet-275	213	31	,	,	PUNCT
admet-275	213	32	and	and	CCONJ
admet-275	213	33	active	active	ADJ
admet-275	213	34	or	or	CCONJ
admet-275	213	35	passive	passive	ADJ
admet-275	213	36	efflux	efflux	NOUN
admet-275	213	37	at	at	ADP
admet-275	213	38	the	the	DET
admet-275	213	39	basolateral	basolateral	ADJ
admet-275	213	40	site	site	NOUN
admet-275	213	41	.	.	PUNCT
admet-275	214	1	moreover	moreover	ADV
admet-275	214	2	transport	transport	NOUN
admet-275	214	3	is	be	AUX
admet-275	214	4	not	not	PART
admet-275	214	5	limited	limit	VERB
admet-275	214	6	to	to	ADP
admet-275	214	7	the	the	DET
admet-275	214	8	apical	apical	ADJ
admet-275	214	9	to	to	ADP
admet-275	214	10	basolateral	basolateral	ADJ
admet-275	214	11	transport	transport	NOUN
admet-275	214	12	determined	determine	VERB
admet-275	214	13	in	in	ADP
admet-275	214	14	this	this	DET
admet-275	214	15	series	series	NOUN
admet-275	214	16	of	of	ADP
admet-275	214	17	experiments	experiment	NOUN
admet-275	214	18	but	but	CCONJ
admet-275	214	19	basolateral	basolateral	ADJ
admet-275	214	20	to	to	ADP
admet-275	214	21	apical	apical	ADJ
admet-275	214	22	movement	movement	NOUN
admet-275	214	23	from	from	ADP
admet-275	214	24	the	the	DET
admet-275	214	25	cell	cell	NOUN
admet-275	214	26	could	could	AUX
admet-275	214	27	play	play	VERB
admet-275	214	28	a	a	DET
admet-275	214	29	crucial	crucial	ADJ
admet-275	214	30	role	role	NOUN
admet-275	214	31	in	in	ADP
admet-275	214	32	the	the	DET
admet-275	214	33	absorption	absorption	NOUN
admet-275	214	34	of	of	ADP
admet-275	214	35	these	these	DET
admet-275	214	36	compounds	compound	NOUN
admet-275	214	37	.	.	PUNCT
admet-275	215	1	cimetidine	cimetidine	NOUN
admet-275	215	2	,	,	PUNCT
admet-275	215	3	desipramine	desipramine	NOUN
admet-275	215	4	and	and	CCONJ
admet-275	215	5	verapamil	verapamil	NOUN
admet-275	215	6	were	be	AUX
admet-275	215	7	investigated	investigate	VERB
admet-275	215	8	in	in	ADP
admet-275	215	9	a	a	DET
admet-275	215	10	model	model	NOUN
admet-275	215	11	gut	gut	NOUN
admet-275	215	12	epithelial	epithelial	ADJ
admet-275	215	13	system	system	NOUN
admet-275	215	14	to	to	PART
admet-275	215	15	elucidate	elucidate	VERB
admet-275	215	16	some	some	PRON
admet-275	215	17	of	of	ADP
admet-275	215	18	the	the	DET
admet-275	215	19	relevance	relevance	NOUN
admet-275	215	20	of	of	ADP
admet-275	215	21	the	the	DET
admet-275	215	22	hoct	hoct	NOUN
admet-275	215	23	role	role	NOUN
admet-275	215	24	.	.	PUNCT
admet-275	216	1	due	due	ADP
admet-275	216	2	to	to	ADP
admet-275	216	3	the	the	DET
admet-275	216	4	various	various	ADJ
admet-275	216	5	locations	location	NOUN
admet-275	216	6	of	of	ADP
admet-275	216	7	the	the	DET
admet-275	216	8	different	different	ADJ
admet-275	216	9	hocts	hoct	NOUN
admet-275	216	10	in	in	ADP
admet-275	216	11	the	the	DET
admet-275	216	12	intestinal	intestinal	ADJ
admet-275	216	13	model	model	NOUN
admet-275	216	14	compared	compare	VERB
admet-275	216	15	to	to	ADP
admet-275	216	16	the	the	DET
admet-275	216	17	tumour	tumour	NOUN
admet-275	216	18	model	model	NOUN
admet-275	216	19	,	,	PUNCT
admet-275	216	20	different	different	ADJ
admet-275	216	21	effects	effect	NOUN
admet-275	216	22	were	be	AUX
admet-275	216	23	observed	observe	VERB
admet-275	216	24	.	.	PUNCT
admet-275	217	1	the	the	DET
admet-275	217	2	hoct	hoct	PROPN
admet-275	217	3	inhibitors	inhibitor	NOUN
admet-275	217	4	did	do	AUX
admet-275	217	5	not	not	PART
admet-275	217	6	have	have	VERB
admet-275	217	7	any	any	DET
admet-275	217	8	effect	effect	NOUN
admet-275	217	9	on	on	ADP
admet-275	217	10	apical	apical	ADJ
admet-275	217	11	to	to	ADP
admet-275	217	12	basolateral	basolateral	ADJ
admet-275	217	13	transport	transport	NOUN
admet-275	217	14	of	of	ADP
admet-275	217	15	erlotinib	erlotinib	NOUN
admet-275	217	16	.	.	PUNCT
admet-275	218	1	nevertheless	nevertheless	ADV
admet-275	218	2	an	an	DET
admet-275	218	3	effect	effect	NOUN
admet-275	218	4	is	be	AUX
admet-275	218	5	seen	see	VERB
admet-275	218	6	in	in	ADP
admet-275	218	7	the	the	DET
admet-275	218	8	accumulation	accumulation	NOUN
admet-275	218	9	of	of	ADP
admet-275	218	10	erlotinib	erlotinib	NOUN
admet-275	218	11	in	in	ADP
admet-275	218	12	the	the	DET
admet-275	218	13	caco-2	caco-2	NUM
admet-275	218	14	intestinal	intestinal	ADJ
admet-275	218	15	monolayer	monolayer	NOUN
admet-275	218	16	.	.	PUNCT
admet-275	219	1	therefore	therefore	ADV
admet-275	219	2	,	,	PUNCT
admet-275	219	3	verapamil	verapamil	NOUN
admet-275	219	4	,	,	PUNCT
admet-275	219	5	desipramine	desipramine	NOUN
admet-275	219	6	and	and	CCONJ
admet-275	219	7	cimetidine	cimetidine	NOUN
admet-275	219	8	might	might	AUX
admet-275	219	9	act	act	VERB
admet-275	219	10	on	on	ADP
admet-275	219	11	different	different	ADJ
admet-275	219	12	mechanisms	mechanism	NOUN
admet-275	219	13	within	within	ADP
admet-275	219	14	the	the	DET
admet-275	219	15	cell	cell	NOUN
admet-275	219	16	.	.	PUNCT
admet-275	220	1	elmeliegy	elmeliegy	VERB
admet-275	220	2	et	et	PROPN
admet-275	220	3	al	al	PROPN
admet-275	220	4	.	.	PUNCT
admet-275	221	1	[	[	X
admet-275	221	2	46	46	NUM
admet-275	221	3	]	]	PUNCT
admet-275	221	4	stated	state	VERB
admet-275	221	5	that	that	SCONJ
admet-275	221	6	erlotinib	erlotinib	NOUN
admet-275	221	7	is	be	AUX
admet-275	221	8	a	a	DET
admet-275	221	9	substrate	substrate	NOUN
admet-275	221	10	for	for	ADP
admet-275	221	11	hoct2	hoct2	NOUN
admet-275	221	12	.	.	PUNCT
admet-275	222	1	in	in	ADP
admet-275	222	2	addition	addition	NOUN
admet-275	222	3	,	,	PUNCT
admet-275	222	4	minematsu	minematsu	NOUN
admet-275	222	5	et	et	NOUN
admet-275	222	6	al	al	PROPN
admet-275	222	7	.	.	PUNCT
admet-275	223	1	[	[	X
admet-275	223	2	28	28	NUM
admet-275	223	3	]	]	PUNCT
admet-275	223	4	showed	show	VERB
admet-275	223	5	that	that	SCONJ
admet-275	223	6	erlotinib	erlotinib	NOUN
admet-275	223	7	had	have	VERB
admet-275	223	8	inhibitory	inhibitory	ADJ
admet-275	223	9	effects	effect	NOUN
admet-275	223	10	on	on	ADP
admet-275	223	11	hoct1	hoct1	NOUN
admet-275	223	12	.	.	PUNCT
admet-275	224	1	in	in	ADP
admet-275	224	2	contrast	contrast	NOUN
admet-275	224	3	to	to	ADP
admet-275	224	4	erlotinib	erlotinib	VERB
admet-275	224	5	,	,	PUNCT
admet-275	224	6	the	the	DET
admet-275	224	7	hoct	hoct	NOUN
admet-275	224	8	inhibitor	inhibitor	NOUN
admet-275	224	9	desipramine	desipramine	NOUN
admet-275	224	10	affected	affect	VERB
admet-275	224	11	apical	apical	ADJ
admet-275	224	12	to	to	ADP
admet-275	224	13	basolateral	basolateral	ADJ
admet-275	224	14	transport	transport	NOUN
admet-275	224	15	of	of	ADP
admet-275	224	16	gefitinib	gefitinib	NOUN
admet-275	224	17	.	.	PUNCT
admet-275	225	1	since	since	SCONJ
admet-275	225	2	the	the	DET
admet-275	225	3	inhibition	inhibition	NOUN
admet-275	225	4	of	of	ADP
admet-275	225	5	hocts	hoct	NOUN
admet-275	225	6	by	by	ADP
admet-275	225	7	desipramine	desipramine	NOUN
admet-275	225	8	induced	induce	VERB
admet-275	225	9	a	a	DET
admet-275	225	10	higher	high	ADJ
admet-275	225	11	apical	apical	NOUN
admet-275	225	12	to	to	ADP
admet-275	225	13	basolateral	basolateral	ADJ
admet-275	225	14	mass	mass	NOUN
admet-275	225	15	transport	transport	NOUN
admet-275	225	16	,	,	PUNCT
admet-275	225	17	it	it	PRON
admet-275	225	18	is	be	AUX
admet-275	225	19	suggested	suggest	VERB
admet-275	225	20	that	that	SCONJ
admet-275	225	21	the	the	DET
admet-275	225	22	inhibition	inhibition	NOUN
admet-275	225	23	of	of	ADP
admet-275	225	24	hoct1	hoct1	NOUN
admet-275	225	25	(	(	PUNCT
admet-275	225	26	on	on	ADP
admet-275	225	27	basolateral	basolateral	ADJ
admet-275	225	28	side	side	NOUN
admet-275	225	29	)	)	PUNCT
admet-275	225	30	had	have	VERB
admet-275	225	31	a	a	DET
admet-275	225	32	greater	great	ADJ
admet-275	225	33	effect	effect	NOUN
admet-275	225	34	than	than	ADP
admet-275	225	35	the	the	DET
admet-275	225	36	inhibition	inhibition	NOUN
admet-275	225	37	of	of	ADP
admet-275	225	38	hoct3	hoct3	NOUN
admet-275	225	39	(	(	PUNCT
admet-275	225	40	on	on	ADP
admet-275	225	41	apical	apical	ADJ
admet-275	225	42	side	side	NOUN
admet-275	225	43	)	)	PUNCT
admet-275	225	44	,	,	PUNCT
admet-275	225	45	which	which	PRON
admet-275	225	46	means	mean	VERB
admet-275	225	47	that	that	SCONJ
admet-275	225	48	there	there	PRON
admet-275	225	49	is	be	VERB
admet-275	225	50	less	less	ADJ
admet-275	225	51	transport	transport	NOUN
admet-275	225	52	back	back	ADV
admet-275	225	53	into	into	ADP
admet-275	225	54	the	the	DET
admet-275	225	55	cell	cell	NOUN
admet-275	225	56	from	from	ADP
admet-275	225	57	basolateral	basolateral	ADJ
admet-275	225	58	to	to	ADP
admet-275	225	59	apical	apical	ADJ
admet-275	225	60	side	side	NOUN
admet-275	225	61	.	.	PUNCT
admet-275	226	1	the	the	DET
admet-275	226	2	lower	low	ADJ
admet-275	226	3	accumulation	accumulation	NOUN
admet-275	226	4	of	of	ADP
admet-275	226	5	gefitinib	gefitinib	NOUN
admet-275	226	6	observed	observe	VERB
admet-275	226	7	in	in	ADP
admet-275	226	8	the	the	DET
admet-275	226	9	caco-2	caco-2	NUM
admet-275	226	10	intestinal	intestinal	ADJ
admet-275	226	11	monolayer	monolayer	NOUN
admet-275	226	12	after	after	SCONJ
admet-275	226	13	the	the	DET
admet-275	226	14	incubation	incubation	NOUN
admet-275	226	15	with	with	ADP
admet-275	226	16	desipramine	desipramine	NOUN
admet-275	226	17	supports	support	VERB
admet-275	226	18	this	this	DET
admet-275	226	19	suggestion	suggestion	NOUN
admet-275	226	20	.	.	PUNCT
admet-275	227	1	the	the	DET
admet-275	227	2	transport	transport	NOUN
admet-275	227	3	of	of	ADP
admet-275	227	4	sunitinib	sunitinib	NOUN
admet-275	227	5	and	and	CCONJ
admet-275	227	6	crizotinib	crizotinib	VERB
admet-275	227	7	from	from	ADP
admet-275	227	8	apical	apical	ADJ
admet-275	227	9	to	to	ADP
admet-275	227	10	basolateral	basolateral	ADJ
admet-275	227	11	side	side	NOUN
admet-275	227	12	differed	differ	VERB
admet-275	227	13	.	.	PUNCT
admet-275	228	1	the	the	DET
admet-275	228	2	hoct	hoct	PROPN
admet-275	228	3	inhibitors	inhibitor	NOUN
admet-275	228	4	showed	show	VERB
admet-275	228	5	only	only	ADV
admet-275	228	6	marginal	marginal	ADJ
admet-275	228	7	effect	effect	NOUN
admet-275	228	8	on	on	ADP
admet-275	228	9	sunitinib	sunitinib	NOUN
admet-275	228	10	transport	transport	NOUN
admet-275	228	11	from	from	ADP
admet-275	228	12	apical	apical	ADJ
admet-275	228	13	to	to	ADP
admet-275	228	14	basolateral	basolateral	ADJ
admet-275	228	15	side	side	NOUN
admet-275	228	16	.	.	PUNCT
admet-275	229	1	in	in	ADP
admet-275	229	2	contrast	contrast	NOUN
admet-275	229	3	,	,	PUNCT
admet-275	229	4	hocts	hoct	NOUN
admet-275	229	5	seem	seem	VERB
admet-275	229	6	involved	involved	ADJ
admet-275	229	7	in	in	ADP
admet-275	229	8	the	the	DET
admet-275	229	9	apical	apical	ADJ
admet-275	229	10	to	to	ADP
admet-275	229	11	basolateral	basolateral	ADJ
admet-275	229	12	transport	transport	NOUN
admet-275	229	13	of	of	ADP
admet-275	229	14	crizotinib	crizotinib	NOUN
admet-275	229	15	.	.	PUNCT
admet-275	230	1	desipramine	desipramine	PROPN
admet-275	230	2	increased	increase	VERB
admet-275	230	3	mass	mass	ADJ
admet-275	230	4	transport	transport	NOUN
admet-275	230	5	of	of	ADP
admet-275	230	6	crizotinib	crizotinib	NOUN
admet-275	230	7	,	,	PUNCT
admet-275	230	8	just	just	ADV
admet-275	230	9	like	like	ADP
admet-275	230	10	gefitinib	gefitinib	NOUN
admet-275	230	11	,	,	PUNCT
admet-275	230	12	from	from	ADP
admet-275	230	13	apical	apical	ADJ
admet-275	230	14	to	to	ADP
admet-275	230	15	basolateral	basolateral	ADJ
admet-275	230	16	site	site	NOUN
admet-275	230	17	.	.	PUNCT
admet-275	231	1	in	in	ADP
admet-275	231	2	addition	addition	NOUN
admet-275	231	3	,	,	PUNCT
admet-275	231	4	cimetidine	cimetidine	PROPN
admet-275	231	5	had	have	VERB
admet-275	231	6	a	a	DET
admet-275	231	7	similar	similar	ADJ
admet-275	231	8	effect	effect	NOUN
admet-275	231	9	as	as	SCONJ
admet-275	231	10	desipramine	desipramine	NOUN
admet-275	231	11	on	on	ADP
admet-275	231	12	crizotinib	crizotinib	ADJ
admet-275	231	13	mass	mass	ADJ
admet-275	231	14	transport	transport	NOUN
admet-275	231	15	.	.	PUNCT
admet-275	232	1	the	the	DET
admet-275	232	2	higher	high	ADJ
admet-275	232	3	sunitinib	sunitinib	NOUN
admet-275	232	4	and	and	CCONJ
admet-275	232	5	crizotinib	crizotinib	VERB
admet-275	232	6	accumulation	accumulation	NOUN
admet-275	232	7	in	in	ADP
admet-275	232	8	the	the	DET
admet-275	232	9	caco-2	caco-2	NUM
admet-275	232	10	intestinal	intestinal	ADJ
admet-275	232	11	monolayer	monolayer	NOUN
admet-275	232	12	after	after	SCONJ
admet-275	232	13	the	the	DET
admet-275	232	14	incubation	incubation	NOUN
admet-275	232	15	of	of	ADP
admet-275	232	16	verapamil	verapamil	NOUN
admet-275	232	17	and	and	CCONJ
admet-275	232	18	cimetidine	cimetidine	NOUN
admet-275	232	19	is	be	AUX
admet-275	232	20	probably	probably	ADV
admet-275	232	21	masked	mask	VERB
admet-275	232	22	by	by	ADP
admet-275	232	23	lysosomal	lysosomal	ADJ
admet-275	232	24	accumulation	accumulation	NOUN
admet-275	232	25	[	[	X
admet-275	232	26	22,39	22,39	NUM
admet-275	232	27	]	]	X
admet-275	232	28	.	.	PUNCT
admet-275	233	1	just	just	ADV
admet-275	233	2	like	like	ADP
admet-275	233	3	sunitinib	sunitinib	NOUN
admet-275	233	4	,	,	PUNCT
admet-275	233	5	sorafenib	sorafenib	PROPN
admet-275	233	6	does	do	AUX
admet-275	233	7	not	not	PART
admet-275	233	8	seem	seem	VERB
admet-275	233	9	to	to	PART
admet-275	233	10	be	be	AUX
admet-275	233	11	dependent	dependent	ADJ
admet-275	233	12	on	on	ADP
admet-275	233	13	hoct	hoct	PROPN
admet-275	233	14	transport	transport	NOUN
admet-275	233	15	from	from	ADP
admet-275	233	16	apical	apical	ADJ
admet-275	233	17	to	to	ADP
admet-275	233	18	basolateral	basolateral	ADJ
admet-275	233	19	side	side	NOUN
admet-275	233	20	.	.	PUNCT
admet-275	234	1	the	the	DET
admet-275	234	2	honeywell	honeywell	PROPN
admet-275	234	3	et	et	PROPN
admet-275	234	4	al	al	PROPN
admet-275	234	5	.	.	PROPN
admet-275	234	6	admet	admet	PROPN
admet-275	234	7	&	&	CCONJ
admet-275	234	8	dmpk	dmpk	PROPN
admet-275	234	9	4(1	4(1	NOUN
admet-275	234	10	)	)	PUNCT
admet-275	234	11	(	(	PUNCT
admet-275	234	12	2016	2016	NUM
admet-275	234	13	)	)	PUNCT
admet-275	234	14	23	23	NUM
admet-275	234	15	-	-	SYM
admet-275	234	16	34	34	NUM
admet-275	234	17	32	32	NUM
admet-275	234	18	hoct	hoct	NOUN
admet-275	234	19	inhibitors	inhibitor	NOUN
admet-275	234	20	also	also	ADV
admet-275	234	21	showed	show	VERB
admet-275	234	22	only	only	ADJ
admet-275	234	23	marginal	marginal	ADJ
admet-275	234	24	effect	effect	NOUN
admet-275	234	25	on	on	ADP
admet-275	234	26	the	the	DET
admet-275	234	27	accumulation	accumulation	NOUN
admet-275	234	28	of	of	ADP
admet-275	234	29	sorafenib	sorafenib	NOUN
admet-275	234	30	in	in	ADP
admet-275	234	31	the	the	DET
admet-275	234	32	caco-2	caco-2	NUM
admet-275	234	33	intestinal	intestinal	ADJ
admet-275	234	34	monolayer	monolayer	NOUN
admet-275	234	35	.	.	PUNCT
admet-275	235	1	just	just	ADV
admet-275	235	2	like	like	ADP
admet-275	235	3	sunitinib	sunitinib	NOUN
admet-275	235	4	and	and	CCONJ
admet-275	235	5	sorafenib	sorafenib	NOUN
admet-275	235	6	,	,	PUNCT
admet-275	235	7	dasatinib	dasatinib	NOUN
admet-275	235	8	does	do	AUX
admet-275	235	9	not	not	PART
admet-275	235	10	seem	seem	VERB
admet-275	235	11	to	to	PART
admet-275	235	12	be	be	AUX
admet-275	235	13	dependent	dependent	ADJ
admet-275	235	14	on	on	ADP
admet-275	235	15	hoct	hoct	PROPN
admet-275	235	16	transport	transport	NOUN
admet-275	235	17	from	from	ADP
admet-275	235	18	apical	apical	ADJ
admet-275	235	19	to	to	ADP
admet-275	235	20	basolateral	basolateral	ADJ
admet-275	235	21	side	side	NOUN
admet-275	235	22	.	.	PUNCT
admet-275	236	1	dasatinib	dasatinib	NOUN
admet-275	236	2	efflux	efflux	VERB
admet-275	236	3	is	be	AUX
admet-275	236	4	likely	likely	ADJ
admet-275	236	5	to	to	PART
admet-275	236	6	be	be	AUX
admet-275	236	7	p	p	NOUN
admet-275	236	8	-	-	PUNCT
admet-275	236	9	gp	gp	NOUN
admet-275	236	10	dependent	dependent	NOUN
admet-275	236	11	and	and	CCONJ
admet-275	236	12	therefore	therefore	ADV
admet-275	236	13	an	an	DET
admet-275	236	14	increase	increase	NOUN
admet-275	236	15	in	in	ADP
admet-275	236	16	dasatinib	dasatinib	NOUN
admet-275	236	17	accumulation	accumulation	NOUN
admet-275	236	18	in	in	ADP
admet-275	236	19	the	the	DET
admet-275	236	20	caco-2	caco-2	NUM
admet-275	236	21	intestinal	intestinal	ADJ
admet-275	236	22	monolayer	monolayer	NOUN
admet-275	236	23	is	be	AUX
admet-275	236	24	seen	see	VERB
admet-275	236	25	after	after	ADP
admet-275	236	26	the	the	DET
admet-275	236	27	incubation	incubation	NOUN
admet-275	236	28	with	with	ADP
admet-275	236	29	verapamil	verapamil	NOUN
admet-275	236	30	.	.	PUNCT
admet-275	237	1	desipramine	desipramine	PROPN
admet-275	237	2	decreased	decrease	VERB
admet-275	237	3	dasatinib	dasatinib	NOUN
admet-275	237	4	accumulation	accumulation	NOUN
admet-275	237	5	in	in	ADP
admet-275	237	6	the	the	DET
admet-275	237	7	caco-2	caco-2	NUM
admet-275	237	8	intestinal	intestinal	ADJ
admet-275	237	9	monolayer	monolayer	NOUN
admet-275	237	10	,	,	PUNCT
admet-275	237	11	so	so	SCONJ
admet-275	237	12	hocts	hoct	NOUN
admet-275	237	13	might	might	AUX
admet-275	237	14	be	be	AUX
admet-275	237	15	involved	involve	VERB
admet-275	237	16	in	in	ADP
admet-275	237	17	basolateral	basolateral	NOUN
admet-275	237	18	to	to	ADP
admet-275	237	19	apical	apical	ADJ
admet-275	237	20	transport	transport	NOUN
admet-275	237	21	of	of	ADP
admet-275	237	22	dasatinib	dasatinib	NOUN
admet-275	237	23	.	.	PUNCT
admet-275	238	1	nevertheless	nevertheless	ADV
admet-275	238	2	,	,	PUNCT
admet-275	238	3	giannoudis	giannoudis	VERB
admet-275	238	4	et	et	NOUN
admet-275	238	5	al	al	PROPN
admet-275	238	6	.	.	PUNCT
admet-275	239	1	[	[	X
admet-275	239	2	42	42	NUM
admet-275	239	3	]	]	PUNCT
admet-275	239	4	suggested	suggest	VERB
admet-275	239	5	that	that	SCONJ
admet-275	239	6	the	the	DET
admet-275	239	7	uptake	uptake	NOUN
admet-275	239	8	of	of	ADP
admet-275	239	9	dasatinib	dasatinib	NOUN
admet-275	239	10	is	be	AUX
admet-275	239	11	not	not	PART
admet-275	239	12	likely	likely	ADJ
admet-275	239	13	to	to	PART
admet-275	239	14	be	be	AUX
admet-275	239	15	dependent	dependent	ADJ
admet-275	239	16	on	on	ADP
admet-275	239	17	hoct1	hoct1	NOUN
admet-275	239	18	(	(	PUNCT
admet-275	239	19	on	on	ADP
admet-275	239	20	basolateral	basolateral	ADJ
admet-275	239	21	side	side	NOUN
admet-275	239	22	)	)	PUNCT
admet-275	239	23	.	.	PUNCT
admet-275	240	1	also	also	ADV
admet-275	240	2	gromicho	gromicho	VERB
admet-275	240	3	et	et	PROPN
admet-275	240	4	al	al	PROPN
admet-275	240	5	.	.	PUNCT
admet-275	241	1	[	[	X
admet-275	241	2	43	43	NUM
admet-275	241	3	]	]	PUNCT
admet-275	241	4	suggested	suggest	VERB
admet-275	241	5	that	that	SCONJ
admet-275	241	6	effective	effective	ADJ
admet-275	241	7	uptake	uptake	NOUN
admet-275	241	8	of	of	ADP
admet-275	241	9	dasatinib	dasatinib	NOUN
admet-275	241	10	is	be	AUX
admet-275	241	11	not	not	PART
admet-275	241	12	likely	likely	ADJ
admet-275	241	13	to	to	PART
admet-275	241	14	occur	occur	VERB
admet-275	241	15	with	with	ADP
admet-275	241	16	the	the	DET
admet-275	241	17	help	help	NOUN
admet-275	241	18	of	of	ADP
admet-275	241	19	hoct1	hoct1	PROPN
admet-275	241	20	.	.	PUNCT
admet-275	242	1	forchap	forchap	PROPN
admet-275	242	2	et	et	PROPN
admet-275	242	3	al	al	PROPN
admet-275	242	4	.	.	PUNCT
admet-275	243	1	[	[	X
admet-275	243	2	47	47	NUM
admet-275	243	3	]	]	PUNCT
admet-275	243	4	concluded	conclude	VERB
admet-275	243	5	that	that	SCONJ
admet-275	243	6	dasatinib	dasatinib	NOUN
admet-275	243	7	is	be	AUX
admet-275	243	8	not	not	PART
admet-275	243	9	primarily	primarily	ADV
admet-275	243	10	transported	transport	VERB
admet-275	243	11	by	by	ADP
admet-275	243	12	hoct1	hoct1	NOUN
admet-275	243	13	.	.	PUNCT
admet-275	244	1	it	it	PRON
admet-275	244	2	can	can	AUX
admet-275	244	3	be	be	AUX
admet-275	244	4	concluded	conclude	VERB
admet-275	244	5	that	that	SCONJ
admet-275	244	6	erlotinib	erlotinib	NOUN
admet-275	244	7	is	be	AUX
admet-275	244	8	actively	actively	ADV
admet-275	244	9	transported	transport	VERB
admet-275	244	10	out	out	ADP
admet-275	244	11	of	of	ADP
admet-275	244	12	the	the	DET
admet-275	244	13	cell	cell	NOUN
admet-275	244	14	,	,	PUNCT
admet-275	244	15	gefitinib	gefitinib	NOUN
admet-275	244	16	and	and	CCONJ
admet-275	244	17	dasatinib	dasatinib	NOUN
admet-275	244	18	uptake	uptake	ADJ
admet-275	244	19	is	be	AUX
admet-275	244	20	also	also	ADV
admet-275	244	21	active	active	ADJ
admet-275	244	22	while	while	SCONJ
admet-275	244	23	sorafenib	sorafenib	NOUN
admet-275	244	24	uptake	uptake	ADJ
admet-275	244	25	is	be	AUX
admet-275	244	26	passive	passive	ADJ
admet-275	244	27	.	.	PUNCT
admet-275	245	1	this	this	DET
admet-275	245	2	study	study	NOUN
admet-275	245	3	suggests	suggest	VERB
admet-275	245	4	that	that	SCONJ
admet-275	245	5	hocts	hoct	NOUN
admet-275	245	6	might	might	AUX
admet-275	245	7	be	be	AUX
admet-275	245	8	involved	involve	VERB
admet-275	245	9	in	in	ADP
admet-275	245	10	the	the	DET
admet-275	245	11	uptake	uptake	NOUN
admet-275	245	12	of	of	ADP
admet-275	245	13	gefitinib	gefitinib	NOUN
admet-275	245	14	,	,	PUNCT
admet-275	245	15	sunitinib	sunitinib	NOUN
admet-275	245	16	,	,	PUNCT
admet-275	245	17	crizotinib	crizotinib	PROPN
admet-275	245	18	,	,	PUNCT
admet-275	245	19	sorafenib	sorafenib	NOUN
admet-275	245	20	and	and	CCONJ
admet-275	245	21	dasatinib	dasatinib	NOUN
admet-275	245	22	in	in	ADP
admet-275	245	23	the	the	DET
admet-275	245	24	tumor	tumor	NOUN
admet-275	245	25	model	model	NOUN
admet-275	245	26	.	.	PUNCT
admet-275	246	1	in	in	ADP
admet-275	246	2	addition	addition	NOUN
admet-275	246	3	,	,	PUNCT
admet-275	246	4	hocts	hoct	NOUN
admet-275	246	5	might	might	AUX
admet-275	246	6	be	be	AUX
admet-275	246	7	involved	involve	VERB
admet-275	246	8	in	in	ADP
admet-275	246	9	the	the	DET
admet-275	246	10	apical	apical	ADJ
admet-275	246	11	to	to	ADP
admet-275	246	12	basolateral	basolateral	ADJ
admet-275	246	13	transport	transport	NOUN
admet-275	246	14	of	of	ADP
admet-275	246	15	gefitinib	gefitinib	NOUN
admet-275	246	16	and	and	CCONJ
admet-275	246	17	crizotinib	crizotinib	VERB
admet-275	246	18	in	in	ADP
admet-275	246	19	the	the	DET
admet-275	246	20	intestinal	intestinal	ADJ
admet-275	246	21	model	model	NOUN
admet-275	246	22	but	but	CCONJ
admet-275	246	23	to	to	ADP
admet-275	246	24	differing	differ	VERB
admet-275	246	25	degree	degree	NOUN
admet-275	246	26	.	.	PUNCT
admet-275	247	1	overall	overall	ADV
admet-275	247	2	,	,	PUNCT
admet-275	247	3	it	it	PRON
admet-275	247	4	can	can	AUX
admet-275	247	5	be	be	AUX
admet-275	247	6	concluded	conclude	VERB
admet-275	247	7	that	that	SCONJ
admet-275	247	8	the	the	DET
admet-275	247	9	six	six	NUM
admet-275	247	10	tkis	tkis	NOUN
admet-275	247	11	are	be	AUX
admet-275	247	12	very	very	ADV
admet-275	247	13	different	different	ADJ
admet-275	247	14	in	in	ADP
admet-275	247	15	accumulation	accumulation	NOUN
admet-275	247	16	and	and	CCONJ
admet-275	247	17	transport	transport	NOUN
admet-275	247	18	.	.	PUNCT
admet-275	248	1	references	reference	NOUN
admet-275	248	2	[	[	X
admet-275	248	3	1	1	NUM
admet-275	248	4	]	]	X
admet-275	248	5	f.	f.	PROPN
admet-275	248	6	broekman	broekman	PROPN
admet-275	248	7	,	,	PUNCT
admet-275	248	8	e.	e.	PROPN
admet-275	248	9	giovannetti	giovannetti	PROPN
admet-275	248	10	,	,	PUNCT
admet-275	248	11	g.j	g.j	PROPN
admet-275	248	12	.	.	PROPN
admet-275	248	13	peters	peters	PROPN
admet-275	248	14	,	,	PUNCT
admet-275	248	15	world	world	NOUN
admet-275	248	16	j.	j.	PROPN
admet-275	248	17	clin	clin	PROPN
admet-275	248	18	.	.	PUNCT
admet-275	249	1	oncol	oncol	ADJ
admet-275	249	2	.	.	PUNCT
admet-275	250	1	2(2	2(2	NUM
admet-275	250	2	)	)	PUNCT
admet-275	251	1	(	(	PUNCT
admet-275	251	2	2011	2011	NUM
admet-275	251	3	)	)	PUNCT
admet-275	251	4	80–93	80–93	NUM
admet-275	251	5	.	.	PUNCT
admet-275	252	1	[	[	X
admet-275	252	2	2	2	X
admet-275	252	3	]	]	PUNCT
admet-275	252	4	j.	j.	PROPN
admet-275	252	5	schlessinger	schlessinger	PROPN
admet-275	252	6	,	,	PUNCT
admet-275	252	7	cell	cell	NOUN
admet-275	252	8	103(2	103(2	NUM
admet-275	252	9	)	)	PUNCT
admet-275	252	10	(	(	PUNCT
admet-275	252	11	2000	2000	NUM
admet-275	252	12	)	)	PUNCT
admet-275	252	13	211–225	211–225	NUM
admet-275	252	14	.	.	PUNCT
admet-275	253	1	[	[	X
admet-275	253	2	3	3	X
admet-275	253	3	]	]	X
admet-275	253	4	s.r	s.r	PROPN
admet-275	253	5	.	.	PROPN
admet-275	253	6	hubbard	hubbard	PROPN
admet-275	253	7	,	,	PUNCT
admet-275	253	8	w.t	w.t	PROPN
admet-275	253	9	.	.	PROPN
admet-275	253	10	miller	miller	PROPN
admet-275	253	11	,	,	PUNCT
admet-275	253	12	curr	curr	PROPN
admet-275	253	13	.	.	PUNCT
admet-275	253	14	opin	opin	NOUN
admet-275	253	15	.	.	PUNCT
admet-275	254	1	cell	cell	NOUN
admet-275	254	2	biol	biol	PROPN
admet-275	254	3	.	.	PUNCT
admet-275	255	1	19(2	19(2	X
admet-275	255	2	)	)	PUNCT
admet-275	255	3	(	(	PUNCT
admet-275	255	4	2007	2007	NUM
admet-275	255	5	)	)	PUNCT
admet-275	256	1	117–123	117–123	NUM
admet-275	256	2	.	.	PUNCT
admet-275	257	1	[	[	X
admet-275	257	2	4	4	NUM
admet-275	257	3	]	]	ADJ
admet-275	257	4	a.	a.	NOUN
admet-275	257	5	gschwind	gschwind	NOUN
admet-275	257	6	,	,	PUNCT
admet-275	257	7	o.m	o.m	PROPN
admet-275	257	8	.	.	PROPN
admet-275	257	9	fischer	fischer	PROPN
admet-275	257	10	,	,	PUNCT
admet-275	257	11	a.	a.	NOUN
admet-275	257	12	ullrich	ullrich	PROPN
admet-275	257	13	,	,	PUNCT
admet-275	257	14	nat	nat	PROPN
admet-275	257	15	.	.	PUNCT
admet-275	257	16	rev	rev	PROPN
admet-275	257	17	.	.	PROPN
admet-275	258	1	cancer	cancer	PROPN
admet-275	258	2	4(5	4(5	PROPN
admet-275	258	3	)	)	PUNCT
admet-275	258	4	(	(	PUNCT
admet-275	258	5	2004	2004	NUM
admet-275	258	6	)	)	PUNCT
admet-275	259	1	361–370	361–370	NUM
admet-275	259	2	.	.	PUNCT
admet-275	260	1	[	[	X
admet-275	260	2	5	5	NUM
admet-275	260	3	]	]	X
admet-275	260	4	m.a	m.a	PROPN
admet-275	260	5	.	.	PROPN
admet-275	260	6	lemmon	lemmon	PROPN
admet-275	260	7	,	,	PUNCT
admet-275	260	8	j.	j.	PROPN
admet-275	260	9	schlessinger	schlessinger	PROPN
admet-275	260	10	,	,	PUNCT
admet-275	260	11	cell	cell	NOUN
admet-275	260	12	141(7	141(7	NUM
admet-275	260	13	)	)	PUNCT
admet-275	260	14	(	(	PUNCT
admet-275	260	15	2010	2010	NUM
admet-275	260	16	)	)	PUNCT
admet-275	260	17	1117–1134	1117–1134	NUM
admet-275	260	18	.	.	PUNCT
admet-275	261	1	[	[	X
admet-275	261	2	6	6	NUM
admet-275	261	3	]	]	X
admet-275	261	4	p.b	p.b	PROPN
admet-275	261	5	.	.	PROPN
admet-275	261	6	allen	allen	PROPN
admet-275	261	7	,	,	PUNCT
admet-275	261	8	l.m	l.m	PROPN
admet-275	261	9	.	.	PROPN
admet-275	261	10	wiedemann	wiedemann	PROPN
admet-275	261	11	,	,	PUNCT
admet-275	261	12	j.	j.	PROPN
admet-275	261	13	biol	biol	PROPN
admet-275	261	14	.	.	PUNCT
admet-275	262	1	chem	chem	NOUN
admet-275	262	2	.	.	PUNCT
admet-275	263	1	271(32	271(32	NUM
admet-275	263	2	)	)	PUNCT
admet-275	263	3	(	(	PUNCT
admet-275	263	4	1996	1996	NUM
admet-275	263	5	)	)	PUNCT
admet-275	264	1	19585–19591	19585–19591	NUM
admet-275	264	2	.	.	PUNCT
admet-275	265	1	[	[	X
admet-275	265	2	7	7	X
admet-275	265	3	]	]	X
admet-275	265	4	d.r	d.r	PROPN
admet-275	265	5	.	.	PROPN
admet-275	265	6	duckett	duckett	PROPN
admet-275	265	7	,	,	PUNCT
admet-275	265	8	m.d	m.d	PROPN
admet-275	265	9	.	.	PROPN
admet-275	265	10	cameron	cameron	PROPN
admet-275	265	11	,	,	PUNCT
admet-275	265	12	expert	expert	NOUN
admet-275	265	13	opin	opin	NOUN
admet-275	265	14	.	.	PUNCT
admet-275	265	15	drug	drug	NOUN
admet-275	265	16	metab	metab	NOUN
admet-275	265	17	.	.	PUNCT
admet-275	266	1	toxicol	toxicol	PROPN
admet-275	266	2	.	.	PUNCT
admet-275	267	1	6(10	6(10	NUM
admet-275	267	2	)	)	PUNCT
admet-275	267	3	(	(	PUNCT
admet-275	267	4	2010	2010	NUM
admet-275	267	5	)	)	PUNCT
admet-275	267	6	1175	1175	NUM
admet-275	267	7	-	-	SYM
admet-275	267	8	1193	1193	NUM
admet-275	267	9	.	.	PUNCT
admet-275	268	1	[	[	X
admet-275	268	2	8	8	NUM
admet-275	268	3	]	]	X
admet-275	268	4	m.h	m.h	PROPN
admet-275	268	5	.	.	PROPN
admet-275	268	6	cohen	cohen	PROPN
admet-275	268	7	,	,	PUNCT
admet-275	268	8	j.r	j.r	PROPN
admet-275	268	9	.	.	PROPN
admet-275	268	10	johnson	johnson	PROPN
admet-275	268	11	,	,	PUNCT
admet-275	268	12	y.-f	y.-f	PROPN
admet-275	268	13	.	.	PUNCT
admet-275	269	1	chen	chen	PROPN
admet-275	269	2	,	,	PUNCT
admet-275	269	3	r.	r.	PROPN
admet-275	269	4	sridhara	sridhara	PROPN
admet-275	269	5	,	,	PUNCT
admet-275	269	6	r.	r.	PROPN
admet-275	269	7	pazdur	pazdur	PROPN
admet-275	269	8	,	,	PUNCT
admet-275	269	9	oncologist	oncologist	NOUN
admet-275	269	10	10(7	10(7	NUM
admet-275	269	11	)	)	PUNCT
admet-275	269	12	(	(	PUNCT
admet-275	269	13	2005	2005	NUM
admet-275	269	14	)	)	PUNCT
admet-275	269	15	461–466	461–466	NUM
admet-275	269	16	.	.	PUNCT
admet-275	270	1	[	[	X
admet-275	270	2	9	9	NUM
admet-275	270	3	]	]	X
admet-275	270	4	m.h	m.h	PROPN
admet-275	270	5	.	.	PROPN
admet-275	270	6	cohen	cohen	PROPN
admet-275	270	7	,	,	PUNCT
admet-275	270	8	oncologist	oncologist	NOUN
admet-275	270	9	8(4	8(4	NUM
admet-275	270	10	)	)	PUNCT
admet-275	270	11	(	(	PUNCT
admet-275	270	12	2003	2003	NUM
admet-275	270	13	)	)	PUNCT
admet-275	271	1	303–306	303–306	NUM
admet-275	271	2	.	.	PUNCT
admet-275	272	1	[	[	X
admet-275	272	2	10	10	NUM
admet-275	272	3	]	]	X
admet-275	272	4	w.s	w.s	PROPN
admet-275	272	5	.	.	PUNCT
admet-275	272	6	siegel	siegel	PROPN
admet-275	272	7	-	-	PUNCT
admet-275	272	8	lakhai	lakhai	ADJ
admet-275	272	9	,	,	PUNCT
admet-275	272	10	j.h	j.h	PROPN
admet-275	272	11	.	.	PROPN
admet-275	272	12	beijnen	beijnen	PROPN
admet-275	272	13	,	,	PUNCT
admet-275	272	14	j.h.m	j.h.m	PROPN
admet-275	272	15	.	.	PUNCT
admet-275	272	16	schellens	schellens	PROPN
admet-275	272	17	,	,	PUNCT
admet-275	272	18	oncologist	oncologist	NOUN
admet-275	272	19	10(8	10(8	NUM
admet-275	272	20	)	)	PUNCT
admet-275	272	21	(	(	PUNCT
admet-275	272	22	2005	2005	NUM
admet-275	272	23	)	)	PUNCT
admet-275	273	1	579–589	579–589	NUM
admet-275	273	2	.	.	PUNCT
admet-275	274	1	[	[	X
admet-275	274	2	11	11	NUM
admet-275	274	3	]	]	X
admet-275	274	4	e.	e.	PROPN
admet-275	274	5	lierman	lierman	PROPN
admet-275	274	6	,	,	PUNCT
admet-275	274	7	i.	i.	PROPN
admet-275	274	8	lahortiga	lahortiga	PROPN
admet-275	274	9	,	,	PUNCT
admet-275	274	10	h.	h.	PROPN
admet-275	274	11	van	van	PROPN
admet-275	274	12	miegroet	miegroet	VERB
admet-275	274	13	,	,	PUNCT
admet-275	274	14	n.	n.	PROPN
admet-275	274	15	mentens	menten	NOUN
admet-275	274	16	,	,	PUNCT
admet-275	274	17	p.	p.	PROPN
admet-275	274	18	marynen	marynen	PROPN
admet-275	274	19	,	,	PUNCT
admet-275	274	20	haematologica	haematologica	PROPN
admet-275	274	21	92(1	92(1	NOUN
admet-275	274	22	)	)	PUNCT
admet-275	274	23	(	(	PUNCT
admet-275	274	24	2007	2007	NUM
admet-275	274	25	)	)	PUNCT
admet-275	274	26	27	27	NUM
admet-275	274	27	–	–	PUNCT
admet-275	274	28	34	34	NUM
admet-275	274	29	.	.	PUNCT
admet-275	275	1	[	[	X
admet-275	275	2	12	12	NUM
admet-275	275	3	]	]	X
admet-275	275	4	r.c	r.c	PROPN
admet-275	275	5	.	.	PROPN
admet-275	275	6	kane	kane	PROPN
admet-275	275	7	,	,	PUNCT
admet-275	275	8	a.t	a.t	PROPN
admet-275	275	9	.	.	PROPN
admet-275	275	10	farrell	farrell	PROPN
admet-275	275	11	,	,	PUNCT
admet-275	275	12	r.	r.	PROPN
admet-275	275	13	madabushi	madabushi	PROPN
admet-275	275	14	,	,	PUNCT
admet-275	275	15	b.	b.	PROPN
admet-275	275	16	booth	booth	PROPN
admet-275	275	17	,	,	PUNCT
admet-275	275	18	s.	s.	PROPN
admet-275	275	19	chattopadhyay	chattopadhyay	PROPN
admet-275	275	20	,	,	PUNCT
admet-275	275	21	r.	r.	PROPN
admet-275	275	22	sridhara	sridhara	PROPN
admet-275	275	23	,	,	PUNCT
admet-275	275	24	r.	r.	PROPN
admet-275	275	25	justice	justice	PROPN
admet-275	275	26	,	,	PUNCT
admet-275	275	27	r.	r.	PROPN
admet-275	275	28	pazdur	pazdur	PROPN
admet-275	275	29	,	,	PUNCT
admet-275	275	30	oncologist	oncologist	NOUN
admet-275	275	31	14(1	14(1	NUM
admet-275	275	32	)	)	PUNCT
admet-275	275	33	(	(	PUNCT
admet-275	275	34	2009	2009	NUM
admet-275	275	35	)	)	PUNCT
admet-275	275	36	95–100	95–100	NUM
admet-275	275	37	.	.	PUNCT
admet-275	276	1	[	[	X
admet-275	276	2	13	13	NUM
admet-275	276	3	]	]	X
admet-275	276	4	r.c	r.c	PROPN
admet-275	276	5	.	.	PROPN
admet-275	276	6	kane	kane	PROPN
admet-275	276	7	,	,	PUNCT
admet-275	276	8	a.t	a.t	PROPN
admet-275	276	9	.	.	PROPN
admet-275	276	10	farrell	farrell	PROPN
admet-275	276	11	,	,	PUNCT
admet-275	276	12	h.	h.	PROPN
admet-275	276	13	saber	saber	PROPN
admet-275	276	14	,	,	PUNCT
admet-275	276	15	s.	s.	PROPN
admet-275	276	16	tang	tang	PROPN
admet-275	276	17	,	,	PUNCT
admet-275	276	18	g.	g.	PROPN
admet-275	276	19	williams	williams	PROPN
admet-275	276	20	,	,	PUNCT
admet-275	276	21	j.m	j.m	PROPN
admet-275	276	22	.	.	PROPN
admet-275	276	23	jee	jee	PROPN
admet-275	276	24	,	,	PUNCT
admet-275	276	25	c.	c.	PROPN
admet-275	276	26	liang	liang	PROPN
admet-275	276	27	,	,	PUNCT
admet-275	276	28	b.	b.	PROPN
admet-275	276	29	booth	booth	PROPN
admet-275	276	30	,	,	PUNCT
admet-275	276	31	n.	n.	PROPN
admet-275	276	32	chidambaram	chidambaram	PROPN
admet-275	276	33	,	,	PUNCT
admet-275	276	34	d.	d.	PROPN
admet-275	276	35	morse	morse	PROPN
admet-275	276	36	,	,	PUNCT
admet-275	276	37	r.	r.	PROPN
admet-275	276	38	sridhara	sridhara	PROPN
admet-275	276	39	,	,	PUNCT
admet-275	276	40	p.	p.	PROPN
admet-275	276	41	garvey	garvey	PROPN
admet-275	276	42	,	,	PUNCT
admet-275	276	43	r.	r.	PROPN
admet-275	276	44	justice	justice	PROPN
admet-275	276	45	,	,	PUNCT
admet-275	276	46	r.	r.	PROPN
admet-275	276	47	pazdur	pazdur	PROPN
admet-275	276	48	,	,	PUNCT
admet-275	276	49	clin	clin	PROPN
admet-275	276	50	.	.	PUNCT
admet-275	277	1	cancer	cancer	NOUN
admet-275	277	2	res	re	NOUN
admet-275	277	3	.	.	PUNCT
admet-275	278	1	12(24	12(24	NUM
admet-275	278	2	)	)	PUNCT
admet-275	278	3	(	(	PUNCT
admet-275	278	4	2006	2006	NUM
admet-275	278	5	)	)	PUNCT
admet-275	278	6	7271–7278	7271–7278	NUM
admet-275	278	7	.	.	PUNCT
admet-275	279	1	[	[	X
admet-275	279	2	14	14	NUM
admet-275	279	3	]	]	X
admet-275	279	4	r.	r.	PROPN
admet-275	279	5	kumar	kumar	PROPN
admet-275	279	6	,	,	PUNCT
admet-275	279	7	m.-c	m.-c	PROPN
admet-275	279	8	.	.	PUNCT
admet-275	280	1	crouthamel	crouthamel	PROPN
admet-275	280	2	,	,	PUNCT
admet-275	280	3	d.h	d.h	PROPN
admet-275	280	4	.	.	PROPN
admet-275	280	5	rominger	rominger	PROPN
admet-275	280	6	,	,	PUNCT
admet-275	280	7	r.r	r.r	PROPN
admet-275	280	8	.	.	PROPN
admet-275	280	9	gontarek	gontarek	PROPN
admet-275	280	10	,	,	PUNCT
admet-275	280	11	p.j	p.j	PROPN
admet-275	280	12	.	.	PROPN
admet-275	280	13	tummino	tummino	PROPN
admet-275	280	14	,	,	PUNCT
admet-275	280	15	r.a	r.a	PROPN
admet-275	280	16	.	.	PROPN
admet-275	280	17	levin	levin	PROPN
admet-275	280	18	,	,	PUNCT
admet-275	280	19	a.g	a.g	PROPN
admet-275	280	20	.	.	PROPN
admet-275	280	21	king	king	PROPN
admet-275	280	22	,	,	PUNCT
admet-275	280	23	br	br	PROPN
admet-275	280	24	.	.	PUNCT
admet-275	281	1	j.	j.	PROPN
admet-275	281	2	cancer	cancer	PROPN
admet-275	281	3	101(10	101(10	PROPN
admet-275	281	4	)	)	PUNCT
admet-275	281	5	(	(	PUNCT
admet-275	281	6	2009	2009	NUM
admet-275	281	7	)	)	PUNCT
admet-275	281	8	1717–1723	1717–1723	NUM
admet-275	281	9	.	.	PUNCT
admet-275	282	1	[	[	X
admet-275	282	2	15	15	NUM
admet-275	282	3	]	]	X
admet-275	282	4	e.p	e.p	PROPN
admet-275	282	5	.	.	PROPN
admet-275	282	6	rock	rock	PROPN
admet-275	282	7	,	,	PUNCT
admet-275	282	8	v.	v.	PROPN
admet-275	282	9	goodman	goodman	PROPN
admet-275	282	10	,	,	PUNCT
admet-275	282	11	j.x	j.x	PROPN
admet-275	282	12	.	.	PROPN
admet-275	282	13	jiang	jiang	PROPN
admet-275	282	14	,	,	PUNCT
admet-275	282	15	k.	k.	PROPN
admet-275	282	16	mahjoob	mahjoob	PROPN
admet-275	282	17	,	,	PUNCT
admet-275	282	18	s.l	s.l	PROPN
admet-275	282	19	.	.	NOUN
admet-275	282	20	verbois	verbois	NOUN
admet-275	282	21	,	,	PUNCT
admet-275	282	22	d.	d.	PROPN
admet-275	282	23	morse	morse	PROPN
admet-275	282	24	,	,	PUNCT
admet-275	282	25	r.	r.	PROPN
admet-275	282	26	dagher	dagher	PROPN
admet-275	282	27	,	,	PUNCT
admet-275	282	28	r.	r.	PROPN
admet-275	282	29	justice	justice	PROPN
admet-275	282	30	,	,	PUNCT
admet-275	282	31	r.	r.	PROPN
admet-275	282	32	pazdur	pazdur	PROPN
admet-275	282	33	,	,	PUNCT
admet-275	282	34	oncologist	oncologist	NOUN
admet-275	282	35	12(1	12(1	NUM
admet-275	282	36	)	)	PUNCT
admet-275	282	37	(	(	PUNCT
admet-275	282	38	2007	2007	NUM
admet-275	282	39	)	)	PUNCT
admet-275	282	40	107–113	107–113	NUM
admet-275	282	41	.	.	PUNCT
admet-275	283	1	[	[	X
admet-275	283	2	16	16	NUM
admet-275	283	3	]	]	PUNCT
admet-275	283	4	a.	a.	NOUN
admet-275	283	5	strimpakos	strimpakos	PROPN
admet-275	283	6	,	,	PUNCT
admet-275	283	7	m.w	m.w	PROPN
admet-275	283	8	.	.	PROPN
admet-275	283	9	saif	saif	PROPN
admet-275	283	10	,	,	PUNCT
admet-275	283	11	k.n	k.n	PROPN
admet-275	283	12	.	.	PROPN
admet-275	283	13	syrigos	syrigos	PROPN
admet-275	283	14	,	,	PUNCT
admet-275	283	15	cancer	cancer	NOUN
admet-275	283	16	metastasis	metastasis	NOUN
admet-275	283	17	rev	rev	VERB
admet-275	283	18	.	.	PUNCT
admet-275	283	19	27(3	27(3	NUM
admet-275	283	20	)	)	PUNCT
admet-275	283	21	(	(	PUNCT
admet-275	283	22	2008	2008	NUM
admet-275	283	23	)	)	PUNCT
admet-275	284	1	495–522	495–522	NUM
admet-275	284	2	.	.	PUNCT
admet-275	285	1	[	[	X
admet-275	285	2	17	17	NUM
admet-275	285	3	]	]	X
admet-275	285	4	m.w	m.w	PROPN
admet-275	285	5	.	.	PROPN
admet-275	285	6	saif	saif	PROPN
admet-275	285	7	,	,	PUNCT
admet-275	285	8	jop	jop	PROPN
admet-275	285	9	.	.	PUNCT
admet-275	286	1	j.	j.	PROPN
admet-275	286	2	pancreas	pancreas	PROPN
admet-275	286	3	12(4	12(4	NUM
admet-275	286	4	)	)	PUNCT
admet-275	286	5	(	(	PUNCT
admet-275	286	6	2011	2011	NUM
admet-275	286	7	)	)	PUNCT
admet-275	286	8	316–321	316–321	NUM
admet-275	286	9	.	.	PUNCT
admet-275	287	1	[	[	X
admet-275	287	2	18	18	NUM
admet-275	287	3	]	]	X
admet-275	287	4	s.j	s.j	PROPN
admet-275	287	5	.	.	PROPN
admet-275	287	6	baker	baker	PROPN
admet-275	287	7	,	,	PUNCT
admet-275	287	8	e.p	e.p	PROPN
admet-275	287	9	.	.	PROPN
admet-275	287	10	reddy	reddy	PROPN
admet-275	287	11	,	,	PUNCT
admet-275	287	12	mt	mt	PROPN
admet-275	287	13	.	.	PROPN
admet-275	287	14	sinai	sinai	PROPN
admet-275	287	15	j.	j.	PROPN
admet-275	287	16	med	med	PROPN
admet-275	287	17	.	.	PUNCT
admet-275	288	1	77(6	77(6	NUM
admet-275	288	2	)	)	PUNCT
admet-275	288	3	(	(	PUNCT
admet-275	288	4	2010	2010	NUM
admet-275	288	5	)	)	PUNCT
admet-275	289	1	573–586	573–586	NUM
admet-275	289	2	.	.	PUNCT
admet-275	290	1	[	[	X
admet-275	290	2	19	19	NUM
admet-275	290	3	]	]	PUNCT
admet-275	290	4	m.	m.	NOUN
admet-275	290	5	brave	brave	ADJ
admet-275	290	6	,	,	PUNCT
admet-275	290	7	v.	v.	PROPN
admet-275	290	8	goodman	goodman	PROPN
admet-275	290	9	,	,	PUNCT
admet-275	290	10	e.	e.	PROPN
admet-275	290	11	kaminskas	kaminskas	PROPN
admet-275	290	12	,	,	PUNCT
admet-275	290	13	a.	a.	PROPN
admet-275	290	14	farrell	farrell	PROPN
admet-275	290	15	,	,	PUNCT
admet-275	290	16	w.	w.	PROPN
admet-275	290	17	timmer	timmer	PROPN
admet-275	290	18	,	,	PUNCT
admet-275	290	19	s.	s.	PROPN
admet-275	290	20	pope	pope	PROPN
admet-275	290	21	,	,	PUNCT
admet-275	290	22	r.	r.	PROPN
admet-275	290	23	harapanhalli	harapanhalli	PROPN
admet-275	290	24	,	,	PUNCT
admet-275	290	25	h.	h.	PROPN
admet-275	290	26	saber	saber	PROPN
admet-275	290	27	,	,	PUNCT
admet-275	290	28	d.	d.	PROPN
admet-275	290	29	morse	morse	PROPN
admet-275	290	30	,	,	PUNCT
admet-275	290	31	j.	j.	PROPN
admet-275	290	32	bullock	bullock	PROPN
admet-275	290	33	,	,	PUNCT
admet-275	290	34	a.	a.	NOUN
admet-275	290	35	men	man	NOUN
admet-275	290	36	,	,	PUNCT
admet-275	290	37	c.	c.	PROPN
admet-275	290	38	noory	noory	PROPN
admet-275	290	39	,	,	PUNCT
admet-275	290	40	r.	r.	PROPN
admet-275	290	41	ramchandani	ramchandani	PROPN
admet-275	290	42	,	,	PUNCT
admet-275	290	43	l.	l.	PROPN
admet-275	290	44	kenna	kenna	PROPN
admet-275	290	45	,	,	PUNCT
admet-275	290	46	b.	b.	PROPN
admet-275	290	47	booth	booth	PROPN
admet-275	290	48	,	,	PUNCT
admet-275	290	49	j.	j.	PROPN
admet-275	290	50	gobburu	gobburu	PROPN
admet-275	290	51	,	,	PUNCT
admet-275	290	52	x.	x.	PROPN
admet-275	290	53	jiang	jiang	PROPN
admet-275	290	54	,	,	PUNCT
admet-275	290	55	r.	r.	PROPN
admet-275	290	56	sridhara	sridhara	PROPN
admet-275	290	57	,	,	PUNCT
admet-275	290	58	r.	r.	PROPN
admet-275	290	59	justice	justice	PROPN
admet-275	290	60	,	,	PUNCT
admet-275	290	61	r.	r.	PROPN
admet-275	290	62	pazdur	pazdur	PROPN
admet-275	290	63	,	,	PUNCT
admet-275	290	64	clin	clin	PROPN
admet-275	290	65	.	.	PUNCT
admet-275	291	1	cancer	cancer	NOUN
admet-275	291	2	res	re	NOUN
admet-275	291	3	.	.	PUNCT
admet-275	292	1	14(2	14(2	NUM
admet-275	292	2	)	)	PUNCT
admet-275	292	3	(	(	PUNCT
admet-275	292	4	2008	2008	NUM
admet-275	292	5	)	)	PUNCT
admet-275	293	1	352–359	352–359	NUM
admet-275	293	2	.	.	PUNCT
admet-275	294	1	[	[	X
admet-275	294	2	20	20	NUM
admet-275	294	3	]	]	X
admet-275	294	4	s.h.i	s.h.i	NOUN
admet-275	294	5	.	.	PUNCT
admet-275	294	6	ou	ou	PROPN
admet-275	294	7	,	,	PUNCT
admet-275	294	8	drug	drug	PROPN
admet-275	294	9	des	des	PROPN
admet-275	294	10	.	.	PROPN
admet-275	294	11	devel	devel	NOUN
admet-275	294	12	.	.	PUNCT
admet-275	295	1	ther	ther	INTJ
admet-275	295	2	.	.	PUNCT
admet-275	296	1	5	5	NUM
admet-275	296	2	(	(	PUNCT
admet-275	296	3	2011	2011	NUM
admet-275	296	4	)	)	PUNCT
admet-275	297	1	471–485	471–485	NUM
admet-275	297	2	.	.	PUNCT
admet-275	298	1	admet	admet	PROPN
admet-275	298	2	&	&	CCONJ
admet-275	298	3	dmpk	dmpk	PROPN
admet-275	298	4	4(1	4(1	NOUN
admet-275	298	5	)	)	PUNCT
admet-275	298	6	(	(	PUNCT
admet-275	298	7	2016	2016	NUM
admet-275	298	8	)	)	PUNCT
admet-275	298	9	23	23	NUM
admet-275	298	10	-	-	SYM
admet-275	298	11	34	34	NUM
admet-275	298	12	transport	transport	NOUN
admet-275	298	13	mechanism	mechanism	NOUN
admet-275	298	14	of	of	ADP
admet-275	298	15	tk	tk	PROPN
admet-275	298	16	inhibitors	inhibitor	NOUN
admet-275	298	17	doi	doi	NOUN
admet-275	298	18	:	:	PUNCT
admet-275	298	19	10.5599	10.5599	NUM
admet-275	298	20	/	/	SYM
admet-275	298	21	admet.4.1.275	admet.4.1.275	PROPN
admet-275	298	22	33	33	NUM
admet-275	298	23	[	[	X
admet-275	298	24	21	21	NUM
admet-275	298	25	]	]	X
admet-275	298	26	i.b	i.b	PROPN
admet-275	298	27	.	.	PROPN
admet-275	298	28	muller	muller	PROPN
admet-275	298	29	,	,	PUNCT
admet-275	298	30	a.j	a.j	PROPN
admet-275	298	31	.	.	PROPN
admet-275	298	32	de	de	PROPN
admet-275	298	33	langen	langen	PROPN
admet-275	298	34	,	,	PUNCT
admet-275	298	35	r.j	r.j	PROPN
admet-275	298	36	.	.	PROPN
admet-275	298	37	honeywell	honeywell	PROPN
admet-275	298	38	,	,	PUNCT
admet-275	298	39	e.	e.	PROPN
admet-275	298	40	giovannetti	giovannetti	PROPN
admet-275	298	41	,	,	PUNCT
admet-275	298	42	g.j	g.j	PROPN
admet-275	298	43	.	.	PROPN
admet-275	298	44	peters	peters	PROPN
admet-275	298	45	,	,	PUNCT
admet-275	298	46	expert	expert	NOUN
admet-275	298	47	rev	rev	X
admet-275	298	48	.	.	PROPN
admet-275	298	49	anticancer	anticancer	NOUN
admet-275	298	50	ther	ther	PROPN
admet-275	298	51	.	.	PUNCT
admet-275	299	1	16(2	16(2	NUM
admet-275	299	2	)	)	PUNCT
admet-275	299	3	(	(	PUNCT
admet-275	299	4	2016	2016	NUM
admet-275	299	5	)	)	PUNCT
admet-275	300	1	147–157	147–157	NUM
admet-275	300	2	.	.	PUNCT
admet-275	301	1	[	[	X
admet-275	301	2	22	22	NUM
admet-275	301	3	]	]	X
admet-275	301	4	da	da	PROPN
admet-275	301	5	silva	silva	PROPN
admet-275	301	6	,	,	PUNCT
admet-275	301	7	c.	c.	PROPN
admet-275	301	8	g.	g.	PROPN
admet-275	301	9	;	;	PUNCT
admet-275	301	10	honeywell	honeywell	PROPN
admet-275	301	11	,	,	PUNCT
admet-275	301	12	r.	r.	PROPN
admet-275	301	13	j.	j.	PROPN
admet-275	301	14	;	;	PUNCT
admet-275	301	15	dekker	dekker	PROPN
admet-275	301	16	,	,	PUNCT
admet-275	301	17	h.	h.	PROPN
admet-275	301	18	;	;	PUNCT
admet-275	301	19	peters	peters	PROPN
admet-275	301	20	,	,	PUNCT
admet-275	301	21	g.	g.	PROPN
admet-275	301	22	j.	j.	PROPN
admet-275	301	23	physicochemical	physicochemical	ADJ
admet-275	301	24	properties	property	NOUN
admet-275	301	25	of	of	ADP
admet-275	301	26	novel	novel	ADJ
admet-275	301	27	protein	protein	NOUN
admet-275	301	28	kinase	kinase	NOUN
admet-275	301	29	inhibitors	inhibitor	NOUN
admet-275	301	30	in	in	ADP
admet-275	301	31	relation	relation	NOUN
admet-275	301	32	to	to	ADP
admet-275	301	33	their	their	PRON
admet-275	301	34	substrate	substrate	NOUN
admet-275	301	35	specificity	specificity	NOUN
admet-275	301	36	for	for	ADP
admet-275	301	37	drug	drug	NOUN
admet-275	301	38	transporters	transporter	NOUN
admet-275	301	39	.	.	PUNCT
admet-275	302	1	expert	expert	NOUN
admet-275	302	2	opin	opin	NOUN
admet-275	302	3	drug	drug	NOUN
admet-275	302	4	metab	metab	NOUN
admet-275	302	5	toxicol	toxicol	NOUN
admet-275	302	6	.	.	PUNCT
admet-275	302	7	2015	2015	NUM
admet-275	302	8	,	,	PUNCT
admet-275	302	9	11	11	NUM
admet-275	302	10	(	(	PUNCT
admet-275	302	11	1744	1744	NUM
admet-275	302	12	-	-	SYM
admet-275	302	13	7607	7607	NUM
admet-275	302	14	(	(	PUNCT
admet-275	302	15	electronic	electronic	ADJ
admet-275	302	16	)	)	PUNCT
admet-275	302	17	)	)	PUNCT
admet-275	302	18	,	,	PUNCT
admet-275	302	19	703–717	703–717	NUM
admet-275	302	20	.	.	PUNCT
admet-275	303	1	[	[	X
admet-275	303	2	23	23	NUM
admet-275	303	3	]	]	X
admet-275	303	4	p.	p.	PROPN
admet-275	303	5	di	di	PROPN
admet-275	303	6	gion	gion	PROPN
admet-275	303	7	,	,	PUNCT
admet-275	303	8	f.	f.	PROPN
admet-275	303	9	kanefendt	kanefendt	PROPN
admet-275	303	10	,	,	PUNCT
admet-275	303	11	a.	a.	NOUN
admet-275	303	12	lindauer	lindauer	PROPN
admet-275	303	13	,	,	PUNCT
admet-275	303	14	m.	m.	NOUN
admet-275	303	15	scheffler	scheffler	NOUN
admet-275	303	16	,	,	PUNCT
admet-275	303	17	o.	o.	PROPN
admet-275	303	18	doroshyenko	doroshyenko	PROPN
admet-275	303	19	,	,	PUNCT
admet-275	303	20	u	u	NOUN
admet-275	303	21	,	,	PUNCT
admet-275	303	22	fuhr	fuhr	PROPN
admet-275	303	23	,	,	PUNCT
admet-275	303	24	j.	j.	PROPN
admet-275	303	25	wolf	wolf	PROPN
admet-275	303	26	,	,	PUNCT
admet-275	303	27	u.	u.	PROPN
admet-275	303	28	jaehde	jaehde	PROPN
admet-275	303	29	,	,	PUNCT
admet-275	303	30	clin	clin	PROPN
admet-275	303	31	.	.	PUNCT
admet-275	303	32	pharmacokinet	pharmacokinet	NOUN
admet-275	303	33	.	.	PUNCT
admet-275	304	1	50(9	50(9	NUM
admet-275	304	2	)	)	PUNCT
admet-275	304	3	(	(	PUNCT
admet-275	304	4	2011	2011	NUM
admet-275	304	5	)	)	PUNCT
admet-275	305	1	551–603	551–603	NUM
admet-275	305	2	.	.	PUNCT
admet-275	306	1	[	[	X
admet-275	306	2	24	24	NUM
admet-275	306	3	]	]	X
admet-275	306	4	c.	c.	PROPN
admet-275	306	5	lemos	lemos	PROPN
admet-275	306	6	,	,	PUNCT
admet-275	306	7	g.	g.	PROPN
admet-275	306	8	jansen	jansen	PROPN
admet-275	306	9	,	,	PUNCT
admet-275	306	10	g.j	g.j	PROPN
admet-275	306	11	.	.	PROPN
admet-275	306	12	peters	peters	PROPN
admet-275	306	13	,	,	PUNCT
admet-275	306	14	br.j	br.j	NOUN
admet-275	306	15	cancer	cancer	NOUN
admet-275	306	16	98(5	98(5	NOUN
admet-275	306	17	)	)	PUNCT
admet-275	306	18	(	(	PUNCT
admet-275	306	19	2008	2008	NUM
admet-275	306	20	)	)	PUNCT
admet-275	306	21	857–862	857–862	NUM
admet-275	306	22	.	.	PUNCT
admet-275	307	1	[	[	X
admet-275	307	2	25	25	NUM
admet-275	307	3	]	]	X
admet-275	307	4	c.	c.	PROPN
admet-275	307	5	lemos	lemos	PROPN
admet-275	307	6	,	,	PUNCT
admet-275	307	7	i.	i.	PROPN
admet-275	307	8	kathmann	kathmann	PROPN
admet-275	307	9	,	,	PUNCT
admet-275	307	10	e.	e.	PROPN
admet-275	307	11	giovannetti	giovannetti	PROPN
admet-275	307	12	,	,	PUNCT
admet-275	307	13	c.	c.	NOUN
admet-275	307	14	calhau	calhau	NOUN
admet-275	307	15	,	,	PUNCT
admet-275	307	16	g.	g.	PROPN
admet-275	307	17	jansen	jansen	PROPN
admet-275	307	18	,	,	PUNCT
admet-275	307	19	g.j	g.j	PROPN
admet-275	307	20	.	.	PROPN
admet-275	307	21	peters	peters	PROPN
admet-275	307	22	,	,	PUNCT
admet-275	307	23	br.j	br.j	NOUN
admet-275	307	24	cancer	cancer	NOUN
admet-275	307	25	100(7	100(7	NUM
admet-275	307	26	)	)	PUNCT
admet-275	307	27	(	(	PUNCT
admet-275	307	28	2009	2009	NUM
admet-275	307	29	)	)	PUNCT
admet-275	307	30	1120–1127	1120–1127	NUM
admet-275	307	31	.	.	PUNCT
admet-275	308	1	[	[	X
admet-275	308	2	26	26	NUM
admet-275	308	3	]	]	X
admet-275	308	4	s.	s.	PROPN
admet-275	308	5	shukla	shukla	PROPN
admet-275	308	6	,	,	PUNCT
admet-275	308	7	z.-s	z.-s	PROPN
admet-275	308	8	.	.	PUNCT
admet-275	309	1	chen	chen	PROPN
admet-275	309	2	,	,	PUNCT
admet-275	309	3	s.v	s.v	PROPN
admet-275	309	4	.	.	PROPN
admet-275	309	5	ambudkar	ambudkar	PROPN
admet-275	309	6	,	,	PUNCT
admet-275	309	7	drug	drug	NOUN
admet-275	309	8	resist	resist	NOUN
admet-275	309	9	.	.	PUNCT
admet-275	310	1	updat	updat	PROPN
admet-275	310	2	.	.	PUNCT
admet-275	311	1	15(1	15(1	NUM
admet-275	311	2	-	-	SYM
admet-275	311	3	2	2	NUM
admet-275	311	4	)	)	PUNCT
admet-275	311	5	(	(	PUNCT
admet-275	311	6	2012	2012	NUM
admet-275	311	7	)	)	PUNCT
admet-275	312	1	70–80	70–80	NUM
admet-275	312	2	.	.	PUNCT
admet-275	313	1	[	[	X
admet-275	313	2	27	27	NUM
admet-275	313	3	]	]	PUNCT
admet-275	313	4	j.	j.	PROPN
admet-275	313	5	thomas	thomas	PROPN
admet-275	313	6	,	,	PUNCT
admet-275	313	7	l.	l.	PROPN
admet-275	313	8	wang	wang	PROPN
admet-275	313	9	,	,	PUNCT
admet-275	313	10	r.e	r.e	PROPN
admet-275	313	11	.	.	PROPN
admet-275	313	12	clark	clark	PROPN
admet-275	313	13	,	,	PUNCT
admet-275	313	14	blood	blood	NOUN
admet-275	313	15	104(12	104(12	NUM
admet-275	313	16	)	)	PUNCT
admet-275	313	17	(	(	PUNCT
admet-275	313	18	2004	2004	NUM
admet-275	313	19	)	)	PUNCT
admet-275	313	20	3739–3745	3739–3745	NUM
admet-275	313	21	.	.	PUNCT
admet-275	314	1	[	[	X
admet-275	314	2	28	28	NUM
admet-275	314	3	]	]	X
admet-275	314	4	t.	t.	NOUN
admet-275	314	5	minematsu	minematsu	PROPN
admet-275	314	6	,	,	PUNCT
admet-275	314	7	k.m	k.m	PROPN
admet-275	314	8	.	.	PROPN
admet-275	314	9	giacomini	giacomini	PROPN
admet-275	314	10	,	,	PUNCT
admet-275	314	11	mol	mol	PROPN
admet-275	314	12	.	.	PUNCT
admet-275	314	13	cancer	cancer	NOUN
admet-275	314	14	ther	ther	PROPN
admet-275	314	15	.	.	PUNCT
admet-275	315	1	10(3	10(3	X
admet-275	315	2	)	)	PUNCT
admet-275	315	3	(	(	PUNCT
admet-275	315	4	2011	2011	NUM
admet-275	315	5	)	)	PUNCT
admet-275	316	1	531–539	531–539	NUM
admet-275	316	2	.	.	PUNCT
admet-275	317	1	[	[	X
admet-275	317	2	29	29	NUM
admet-275	317	3	]	]	X
admet-275	317	4	k.m	k.m	PROPN
admet-275	317	5	.	.	PROPN
admet-275	317	6	giacomini	giacomini	PROPN
admet-275	317	7	,	,	PUNCT
admet-275	317	8	s.m	s.m	PROPN
admet-275	317	9	.	.	PROPN
admet-275	317	10	huang	huang	PROPN
admet-275	317	11	,	,	PUNCT
admet-275	317	12	d.j	d.j	PROPN
admet-275	317	13	.	.	PROPN
admet-275	317	14	tweedie	tweedie	PROPN
admet-275	317	15	,	,	PUNCT
admet-275	317	16	l.z	l.z	PROPN
admet-275	317	17	.	.	PROPN
admet-275	317	18	benet	benet	PROPN
admet-275	317	19	,	,	PUNCT
admet-275	317	20	k.l.r	k.l.r	PROPN
admet-275	317	21	.	.	PUNCT
admet-275	317	22	brouwer	brouwer	PROPN
admet-275	317	23	,	,	PUNCT
admet-275	317	24	x.	x.	PROPN
admet-275	317	25	chu	chu	PROPN
admet-275	317	26	,	,	PUNCT
admet-275	317	27	a.	a.	PROPN
admet-275	317	28	dahlin	dahlin	PROPN
admet-275	317	29	,	,	PUNCT
admet-275	317	30	r.	r.	PROPN
admet-275	317	31	evers	evers	PROPN
admet-275	317	32	,	,	PUNCT
admet-275	317	33	v.	v.	CCONJ
admet-275	317	34	fischer	fischer	PROPN
admet-275	317	35	,	,	PUNCT
admet-275	317	36	k.m	k.m	PROPN
admet-275	317	37	.	.	PROPN
admet-275	317	38	hillgren	hillgren	PROPN
admet-275	317	39	,	,	PUNCT
admet-275	317	40	k.a	k.a	PROPN
admet-275	317	41	.	.	PROPN
admet-275	317	42	hoffmaster	hoffmaster	PROPN
admet-275	317	43	,	,	PUNCT
admet-275	317	44	t.	t.	PROPN
admet-275	317	45	ishikawa	ishikawa	PROPN
admet-275	317	46	,	,	PUNCT
admet-275	317	47	d.	d.	PROPN
admet-275	317	48	keppler	keppler	PROPN
admet-275	317	49	,	,	PUNCT
admet-275	317	50	r.b	r.b	PROPN
admet-275	317	51	.	.	PROPN
admet-275	317	52	kim	kim	PROPN
admet-275	317	53	,	,	PUNCT
admet-275	317	54	c.a	c.a	PROPN
admet-275	317	55	.	.	PROPN
admet-275	317	56	lee	lee	PROPN
admet-275	317	57	,	,	PUNCT
admet-275	317	58	m.	m.	PROPN
admet-275	317	59	niemi	niemi	PROPN
admet-275	317	60	,	,	PUNCT
admet-275	317	61	j.w	j.w	PROPN
admet-275	317	62	.	.	PROPN
admet-275	317	63	polli	polli	PROPN
admet-275	317	64	,	,	PUNCT
admet-275	317	65	y.	y.	PROPN
admet-275	317	66	sugiyama	sugiyama	PROPN
admet-275	317	67	,	,	PUNCT
admet-275	317	68	p.w	p.w	PROPN
admet-275	317	69	.	.	PROPN
admet-275	317	70	swaan	swaan	PROPN
admet-275	317	71	,	,	PUNCT
admet-275	317	72	j.a	j.a	PROPN
admet-275	317	73	.	.	PROPN
admet-275	317	74	ware	ware	PROPN
admet-275	317	75	,	,	PUNCT
admet-275	317	76	s.h	s.h	PROPN
admet-275	317	77	.	.	PROPN
admet-275	317	78	wright	wright	PROPN
admet-275	317	79	,	,	PUNCT
admet-275	317	80	s.w	s.w	PROPN
admet-275	317	81	.	.	PROPN
admet-275	317	82	yee	yee	PROPN
admet-275	317	83	,	,	PUNCT
admet-275	317	84	m.j	m.j	PROPN
admet-275	317	85	.	.	PROPN
admet-275	317	86	zamek	zamek	PROPN
admet-275	317	87	-	-	PUNCT
admet-275	317	88	gliszczynski	gliszczynski	PROPN
admet-275	317	89	,	,	PUNCT
admet-275	317	90	l.	l.	PROPN
admet-275	317	91	zhang	zhang	PROPN
admet-275	317	92	,	,	PUNCT
admet-275	317	93	nat	nat	PROPN
admet-275	317	94	.	.	PUNCT
admet-275	318	1	rev	rev	PROPN
admet-275	318	2	.	.	PROPN
admet-275	318	3	drug	drug	NOUN
admet-275	318	4	discov	discov	NOUN
admet-275	318	5	.	.	PUNCT
admet-275	319	1	9(3	9(3	NUM
admet-275	319	2	)	)	PUNCT
admet-275	319	3	(	(	PUNCT
admet-275	319	4	2010	2010	NUM
admet-275	319	5	)	)	PUNCT
admet-275	320	1	215–236	215–236	NUM
admet-275	320	2	.	.	PUNCT
admet-275	321	1	[	[	X
admet-275	321	2	30	30	NUM
admet-275	321	3	]	]	PUNCT
admet-275	321	4	p.	p.	PROPN
admet-275	321	5	artursson	artursson	PROPN
admet-275	321	6	,	,	PUNCT
admet-275	321	7	k.	k.	PROPN
admet-275	321	8	palm	palm	PROPN
admet-275	321	9	,	,	PUNCT
admet-275	321	10	k.	k.	PROPN
admet-275	321	11	luthman	luthman	PROPN
admet-275	321	12	,	,	PUNCT
admet-275	321	13	adv	adv	PROPN
admet-275	321	14	.	.	PUNCT
admet-275	321	15	drug	drug	PROPN
admet-275	321	16	deliv	deliv	PROPN
admet-275	321	17	.	.	PUNCT
admet-275	322	1	rev	rev	PROPN
admet-275	322	2	.	.	PROPN
admet-275	323	1	46(1	46(1	AUX
admet-275	323	2	-	-	PUNCT
admet-275	323	3	3	3	NUM
admet-275	323	4	)	)	PUNCT
admet-275	323	5	(	(	PUNCT
admet-275	323	6	2001	2001	NUM
admet-275	323	7	)	)	PUNCT
admet-275	323	8	27–43	27–43	NOUN
admet-275	323	9	.	.	PUNCT
admet-275	324	1	[	[	X
admet-275	324	2	31	31	NUM
admet-275	324	3	]	]	X
admet-275	324	4	c.	c.	PROPN
admet-275	324	5	lemos	lemos	PROPN
admet-275	324	6	,	,	PUNCT
admet-275	324	7	a.	a.	PROPN
admet-275	324	8	faria	faria	PROPN
admet-275	324	9	,	,	PUNCT
admet-275	324	10	m.	m.	NOUN
admet-275	324	11	meireles	meirele	NOUN
admet-275	324	12	,	,	PUNCT
admet-275	324	13	f.	f.	PROPN
admet-275	324	14	martel	martel	PROPN
admet-275	324	15	,	,	PUNCT
admet-275	324	16	r.	r.	PROPN
admet-275	324	17	monteiro	monteiro	PROPN
admet-275	324	18	,	,	PUNCT
admet-275	324	19	c.	c.	NOUN
admet-275	324	20	calhau	calhau	NOUN
admet-275	324	21	,	,	PUNCT
admet-275	324	22	eur	eur	PROPN
admet-275	324	23	.	.	PUNCT
admet-275	325	1	j.	j.	PROPN
admet-275	325	2	pharmacol	pharmacol	PROPN
admet-275	325	3	.	.	PUNCT
admet-275	326	1	682(1	682(1	NUM
admet-275	326	2	-	-	SYM
admet-275	326	3	3	3	NUM
admet-275	326	4	)	)	PUNCT
admet-275	326	5	(	(	PUNCT
admet-275	326	6	2012	2012	NUM
admet-275	326	7	)	)	PUNCT
admet-275	326	8	37–42	37–42	NUM
admet-275	326	9	.	.	PUNCT
admet-275	327	1	[	[	X
admet-275	327	2	32	32	NUM
admet-275	327	3	]	]	PUNCT
admet-275	327	4	m.	m.	NOUN
admet-275	327	5	roth	roth	PROPN
admet-275	327	6	,	,	PUNCT
admet-275	327	7	a.	a.	NOUN
admet-275	327	8	obaidat	obaidat	PROPN
admet-275	327	9	,	,	PUNCT
admet-275	327	10	b.	b.	PROPN
admet-275	327	11	hagenbuch	hagenbuch	PROPN
admet-275	327	12	,	,	PUNCT
admet-275	327	13	br	br	PROPN
admet-275	327	14	.	.	PUNCT
admet-275	327	15	j.	j.	PROPN
admet-275	327	16	pharmacol	pharmacol	PROPN
admet-275	327	17	.	.	PUNCT
admet-275	328	1	165(5	165(5	NUM
admet-275	328	2	)	)	PUNCT
admet-275	328	3	(	(	PUNCT
admet-275	328	4	2012	2012	NUM
admet-275	328	5	)	)	PUNCT
admet-275	328	6	1260–1287	1260–1287	NUM
admet-275	328	7	.	.	PUNCT
admet-275	329	1	[	[	X
admet-275	329	2	33	33	NUM
admet-275	329	3	]	]	PUNCT
admet-275	329	4	r.	r.	PROPN
admet-275	329	5	honeywell	honeywell	PROPN
admet-275	329	6	,	,	PUNCT
admet-275	329	7	c.	c.	PROPN
admet-275	329	8	fatmawati	fatmawati	PROPN
admet-275	329	9	,	,	PUNCT
admet-275	329	10	m.	m.	NOUN
admet-275	329	11	buddha	buddha	PROPN
admet-275	329	12	,	,	PUNCT
admet-275	329	13	s.	s.	PROPN
admet-275	329	14	hitzerd	hitzerd	PROPN
admet-275	329	15	,	,	PUNCT
admet-275	329	16	i.	i.	PROPN
admet-275	329	17	kathman	kathman	PROPN
admet-275	329	18	,	,	PUNCT
admet-275	329	19	g.	g.	PROPN
admet-275	329	20	peters	peters	PROPN
admet-275	329	21	,	,	PUNCT
admet-275	329	22	admet	admet	NOUN
admet-275	329	23	and	and	CCONJ
admet-275	329	24	dmpk	dmpk	NOUN
admet-275	329	25	3(1	3(1	NUM
admet-275	329	26	)	)	PUNCT
admet-275	329	27	(	(	PUNCT
admet-275	329	28	2015	2015	NUM
admet-275	329	29	)	)	PUNCT
admet-275	329	30	51–67	51–67	NUM
admet-275	329	31	.	.	PUNCT
admet-275	330	1	[	[	X
admet-275	330	2	34	34	NUM
admet-275	330	3	]	]	X
admet-275	330	4	r.	r.	PROPN
admet-275	330	5	honeywell	honeywell	PROPN
admet-275	330	6	,	,	PUNCT
admet-275	330	7	k.	k.	PROPN
admet-275	330	8	yarzadah	yarzadah	PROPN
admet-275	330	9	,	,	PUNCT
admet-275	330	10	e.	e.	PROPN
admet-275	330	11	giovannetti	giovannetti	PROPN
admet-275	330	12	,	,	PUNCT
admet-275	330	13	n.	n.	NOUN
admet-275	330	14	losekoot	losekoot	NOUN
admet-275	330	15	,	,	PUNCT
admet-275	330	16	e.f	e.f	PROPN
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admet-275	330	22	,	,	PUNCT
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admet-275	330	29	,	,	PUNCT
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admet-275	330	33	,	,	PUNCT
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admet-275	330	37	,	,	PUNCT
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admet-275	330	40	.	.	PUNCT
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admet-275	331	3	.	.	PUNCT
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admet-275	332	2	.	.	PROPN
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admet-275	332	4	.	.	PUNCT
admet-275	333	1	life	life	PROPN
admet-275	333	2	sci	sci	PROPN
admet-275	333	3	.	.	PUNCT
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admet-275	334	2	-	-	SYM
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admet-275	334	4	)	)	PUNCT
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admet-275	334	6	2010	2010	NUM
admet-275	334	7	)	)	PUNCT
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admet-275	334	9	.	.	PUNCT
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admet-275	335	3	]	]	X
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admet-275	335	6	-	-	PUNCT
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admet-275	335	8	,	,	PUNCT
admet-275	335	9	o.	o.	PROPN
admet-275	335	10	von	von	PROPN
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admet-275	335	14	burk	burk	PROPN
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admet-275	335	18	,	,	PUNCT
admet-275	335	19	t.	t.	PROPN
admet-275	335	20	mettang	mettang	PROPN
admet-275	335	21	,	,	PUNCT
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admet-275	335	24	,	,	PUNCT
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admet-275	335	28	,	,	PUNCT
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admet-275	335	31	.	.	PUNCT
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admet-275	336	2	.	.	PUNCT
admet-275	337	1	ther	ther	PROPN
admet-275	337	2	.	.	PUNCT
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admet-275	338	2	)	)	PUNCT
admet-275	338	3	(	(	PUNCT
admet-275	338	4	2000	2000	NUM
admet-275	338	5	)	)	PUNCT
admet-275	339	1	376–382	376–382	NUM
admet-275	339	2	.	.	PUNCT
admet-275	340	1	[	[	X
admet-275	340	2	36	36	NUM
admet-275	340	3	]	]	X
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admet-275	340	5	koepsell	koepsell	PROPN
admet-275	340	6	,	,	PUNCT
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admet-275	340	8	.	.	PROPN
admet-275	340	9	schmitt	schmitt	PROPN
admet-275	340	10	,	,	PUNCT
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admet-275	340	14	rev	rev	PROPN
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admet-275	340	17	.	.	PUNCT
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admet-275	341	2	.	.	PUNCT
admet-275	342	1	pharmacol	pharmacol	PROPN
admet-275	342	2	.	.	PROPN
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admet-275	343	2	(	(	PUNCT
admet-275	343	3	2003	2003	NUM
admet-275	343	4	)	)	PUNCT
admet-275	344	1	36–90	36–90	NUM
admet-275	344	2	.	.	PUNCT
admet-275	345	1	[	[	X
admet-275	345	2	37	37	NUM
admet-275	345	3	]	]	PUNCT
admet-275	345	4	s.	s.	PROPN
admet-275	345	5	chong	chong	PROPN
admet-275	345	6	,	,	PUNCT
admet-275	345	7	s.a	s.a	PROPN
admet-275	345	8	.	.	PROPN
admet-275	345	9	dando	dando	PROPN
admet-275	345	10	,	,	PUNCT
admet-275	345	11	r.a	r.a	PROPN
admet-275	345	12	.	.	PROPN
admet-275	345	13	morrison	morrison	PROPN
admet-275	345	14	,	,	PUNCT
admet-275	345	15	pharm	pharm	PROPN
admet-275	345	16	.	.	PUNCT
admet-275	346	1	res	re	NOUN
admet-275	346	2	.	.	PROPN
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admet-275	347	2	)	)	PUNCT
admet-275	347	3	(	(	PUNCT
admet-275	347	4	1997	1997	NUM
admet-275	347	5	)	)	PUNCT
admet-275	347	6	1835–1837	1835–1837	NUM
admet-275	347	7	.	.	PUNCT
admet-275	348	1	[	[	X
admet-275	348	2	38	38	NUM
admet-275	348	3	]	]	PUNCT
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admet-275	348	8	konishi	konishi	PROPN
admet-275	348	9	,	,	PUNCT
admet-275	348	10	y.	y.	PROPN
admet-275	348	11	yamazaki	yamazaki	PROPN
admet-275	348	12	,	,	PUNCT
admet-275	348	13	y.	y.	PROPN
admet-275	348	14	taki	taki	PROPN
admet-275	348	15	,	,	PUNCT
admet-275	348	16	t.	t.	PROPN
admet-275	348	17	sakane	sakane	PROPN
admet-275	348	18	,	,	PUNCT
admet-275	348	19	h.	h.	PROPN
admet-275	348	20	sezaki	sezaki	PROPN
admet-275	348	21	,	,	PUNCT
admet-275	348	22	y.	y.	PROPN
admet-275	348	23	furuyama	furuyama	PROPN
admet-275	348	24	,	,	PUNCT
admet-275	348	25	j.	j.	PROPN
admet-275	348	26	pharm	pharm	PROPN
admet-275	348	27	.	.	PUNCT
admet-275	349	1	sci	sci	PROPN
admet-275	349	2	.	.	PUNCT
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admet-275	350	2	)	)	PUNCT
admet-275	350	3	(	(	PUNCT
admet-275	350	4	2002	2002	NUM
admet-275	350	5	)	)	PUNCT
admet-275	351	1	669–679	669–679	NUM
admet-275	351	2	.	.	PUNCT
admet-275	352	1	[	[	X
admet-275	352	2	39	39	NUM
admet-275	352	3	]	]	X
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admet-275	352	5	.	.	PROPN
admet-275	352	6	gotink	gotink	PROPN
admet-275	352	7	,	,	PUNCT
admet-275	352	8	h.j	h.j	PROPN
admet-275	352	9	.	.	PROPN
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admet-275	352	11	,	,	PUNCT
admet-275	352	12	m.	m.	NOUN
admet-275	352	13	labots	labots	PROPN
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admet-275	352	19	,	,	PUNCT
admet-275	352	20	h.	h.	PROPN
admet-275	352	21	dekker	dekker	PROPN
admet-275	352	22	,	,	PUNCT
admet-275	352	23	r.j	r.j	PROPN
admet-275	352	24	.	.	PROPN
admet-275	352	25	honeywell	honeywell	PROPN
admet-275	352	26	,	,	PUNCT
admet-275	352	27	m.a	m.a	PROPN
admet-275	352	28	.	.	PROPN
admet-275	352	29	rudek	rudek	PROPN
admet-275	352	30	,	,	PUNCT
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admet-275	352	32	.	.	PROPN
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admet-275	352	34	,	,	PUNCT
admet-275	352	35	r.j	r.j	PROPN
admet-275	352	36	.	.	PROPN
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admet-275	352	41	,	,	PUNCT
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admet-275	352	45	,	,	PUNCT
admet-275	352	46	y.g	y.g	PROPN
admet-275	352	47	.	.	PROPN
admet-275	352	48	assaraf	assaraf	PROPN
admet-275	352	49	,	,	PUNCT
admet-275	352	50	r.	r.	PROPN
admet-275	352	51	pili	pili	PROPN
admet-275	352	52	,	,	PUNCT
admet-275	352	53	g.j	g.j	PROPN
admet-275	352	54	.	.	PROPN
admet-275	352	55	peters	peters	PROPN
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admet-275	352	57	h.m.w	h.m.w	PROPN
admet-275	352	58	.	.	PROPN
admet-275	352	59	verheul	verheul	PROPN
admet-275	352	60	,	,	PUNCT
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admet-275	352	62	res	re	NOUN
admet-275	352	63	.	.	PUNCT
admet-275	352	64	17(23	17(23	NOUN
admet-275	352	65	)	)	PUNCT
admet-275	352	66	(	(	PUNCT
admet-275	352	67	2011	2011	NUM
admet-275	352	68	)	)	PUNCT
admet-275	352	69	7337–7346	7337–7346	NUM
admet-275	352	70	.	.	PUNCT
admet-275	353	1	[	[	X
admet-275	353	2	40	40	NUM
admet-275	353	3	]	]	PUNCT
admet-275	353	4	w.-k	w.-k	PROPN
admet-275	353	5	.	.	PUNCT
admet-275	354	1	lee	lee	PROPN
admet-275	354	2	,	,	PUNCT
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admet-275	354	5	,	,	PUNCT
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admet-275	354	8	,	,	PUNCT
admet-275	354	9	g.	g.	PROPN
admet-275	354	10	ciarimboli	ciarimboli	PROPN
admet-275	354	11	,	,	PUNCT
admet-275	354	12	r.	r.	PROPN
admet-275	354	13	warth	warth	PROPN
admet-275	354	14	,	,	PUNCT
admet-275	354	15	h.	h.	PROPN
admet-275	354	16	koepsell	koepsell	PROPN
admet-275	354	17	,	,	PUNCT
admet-275	354	18	f.	f.	PROPN
admet-275	354	19	thévenod	thévenod	PROPN
admet-275	354	20	,	,	PUNCT
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admet-275	354	22	.	.	PUNCT
admet-275	355	1	j.	j.	PROPN
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admet-275	355	3	.	.	PUNCT
admet-275	356	1	renal	renal	PROPN
admet-275	356	2	physiol	physiol	PROPN
admet-275	356	3	.	.	PUNCT
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admet-275	357	2	)	)	PUNCT
admet-275	357	3	(	(	PUNCT
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admet-275	357	5	)	)	PUNCT
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admet-275	357	7	–	–	PUNCT
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admet-275	357	9	.	.	PUNCT
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admet-275	358	2	41	41	NUM
admet-275	358	3	]	]	PUNCT
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admet-275	358	6	,	,	PUNCT
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admet-275	358	35	mutti	mutti	PROPN
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admet-275	358	41	tiseo	tiseo	PROPN
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admet-275	358	45	,	,	PUNCT
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admet-275	358	49	,	,	PUNCT
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admet-275	358	51	.	.	PUNCT
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admet-275	360	2	)	)	PUNCT
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admet-275	360	5	)	)	PUNCT
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admet-275	361	2	.	.	PUNCT
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admet-275	362	3	]	]	PUNCT
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admet-275	362	27	)	)	PUNCT
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admet-275	362	29	2008	2008	NUM
admet-275	362	30	)	)	PUNCT
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admet-275	362	32	.	.	PUNCT
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admet-275	363	3	]	]	PUNCT
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admet-275	364	6	)	)	PUNCT
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admet-275	364	8	.	.	PUNCT
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admet-275	365	3	]	]	PUNCT
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admet-275	365	19	m.	m.	NOUN
admet-275	365	20	rudek	rudek	PROPN
admet-275	365	21	,	,	PUNCT
admet-275	365	22	a.	a.	NOUN
admet-275	365	23	sparreboom	sparreboom	PROPN
admet-275	365	24	,	,	PUNCT
admet-275	365	25	s.d	s.d	PROPN
admet-275	365	26	.	.	PROPN
admet-275	365	27	baker	baker	PROPN
admet-275	365	28	,	,	PUNCT
admet-275	365	29	clin	clin	PROPN
admet-275	365	30	.	.	PUNCT
admet-275	366	1	cancer	cancer	NOUN
admet-275	366	2	res	re	NOUN
admet-275	366	3	.	.	PUNCT
admet-275	367	1	15(19	15(19	NUM
admet-275	367	2	)	)	PUNCT
admet-275	367	3	(	(	PUNCT
admet-275	367	4	2009	2009	NUM
admet-275	367	5	)	)	PUNCT
admet-275	367	6	6062–6069	6062–6069	NUM
admet-275	367	7	.	.	PUNCT
admet-275	368	1	[	[	X
admet-275	368	2	45	45	NUM
admet-275	368	3	]	]	X
admet-275	368	4	n.	n.	PROPN
admet-275	368	5	de	de	PROPN
admet-275	368	6	vries	vries	PROPN
admet-275	368	7	,	,	PUNCT
admet-275	368	8	t.	t.	NOUN
admet-275	368	9	buckle	buckle	PROPN
admet-275	368	10	,	,	PUNCT
admet-275	368	11	j.	j.	PROPN
admet-275	368	12	zhao	zhao	PROPN
admet-275	368	13	,	,	PUNCT
admet-275	368	14	j.h	j.h	PROPN
admet-275	368	15	.	.	PROPN
admet-275	368	16	beijnen	beijnen	PROPN
admet-275	368	17	,	,	PUNCT
admet-275	368	18	j.h.m	j.h.m	PROPN
admet-275	368	19	.	.	PUNCT
admet-275	368	20	schellens	schellens	PROPN
admet-275	368	21	,	,	PUNCT
admet-275	368	22	o.	o.	PROPN
admet-275	368	23	van	van	PROPN
admet-275	368	24	tellingen	tellingen	PROPN
admet-275	368	25	,	,	PUNCT
admet-275	368	26	invest	invest	VERB
admet-275	368	27	.	.	PUNCT
admet-275	369	1	new	new	ADJ
admet-275	369	2	drugs	drug	NOUN
admet-275	369	3	30(2	30(2	NUM
admet-275	369	4	)	)	PUNCT
admet-275	369	5	(	(	PUNCT
admet-275	369	6	2012	2012	NUM
admet-275	369	7	)	)	PUNCT
admet-275	369	8	443–449	443–449	NUM
admet-275	369	9	.	.	PUNCT
admet-275	370	1	honeywell	honeywell	PROPN
admet-275	370	2	et	et	PROPN
admet-275	370	3	al	al	PROPN
admet-275	370	4	.	.	PROPN
admet-275	370	5	admet	admet	PROPN
admet-275	370	6	&	&	CCONJ
admet-275	370	7	dmpk	dmpk	PROPN
admet-275	370	8	4(1	4(1	NOUN
admet-275	370	9	)	)	PUNCT
admet-275	370	10	(	(	PUNCT
admet-275	370	11	2016	2016	NUM
admet-275	370	12	)	)	PUNCT
admet-275	370	13	23	23	NUM
admet-275	370	14	-	-	SYM
admet-275	370	15	34	34	NUM
admet-275	370	16	34	34	NUM
admet-275	370	17	[	[	X
admet-275	370	18	46	46	NUM
admet-275	370	19	]	]	X
admet-275	370	20	m.a	m.a	PROPN
admet-275	370	21	.	.	PROPN
admet-275	370	22	elmeliegy	elmeliegy	PROPN
admet-275	370	23	,	,	PUNCT
admet-275	370	24	a.m.	a.m.	PROPN
admet-275	370	25	carcaboso	carcaboso	PROPN
admet-275	370	26	,	,	PUNCT
admet-275	370	27	m.	m.	NOUN
admet-275	370	28	tagen	tagen	PROPN
admet-275	370	29	,	,	PUNCT
admet-275	370	30	f.	f.	PROPN
admet-275	370	31	bai	bai	PROPN
admet-275	370	32	,	,	PUNCT
admet-275	370	33	c.f	c.f	PROPN
admet-275	370	34	.	.	PROPN
admet-275	370	35	stewart	stewart	PROPN
admet-275	370	36	,	,	PUNCT
admet-275	370	37	clin	clin	PROPN
admet-275	370	38	.	.	PUNCT
admet-275	371	1	cancer	cancer	NOUN
admet-275	371	2	res	re	NOUN
admet-275	371	3	.	.	PUNCT
admet-275	372	1	17(1	17(1	NUM
admet-275	372	2	)	)	PUNCT
admet-275	372	3	(	(	PUNCT
admet-275	372	4	2011	2011	NUM
admet-275	372	5	)	)	PUNCT
admet-275	372	6	89	89	NUM
admet-275	372	7	–	–	PUNCT
admet-275	372	8	99	99	NUM
admet-275	372	9	.	.	PUNCT
admet-275	373	1	[	[	X
admet-275	373	2	47	47	NUM
admet-275	373	3	]	]	X
admet-275	373	4	s.l	s.l	PROPN
admet-275	373	5	.	.	PROPN
admet-275	373	6	forchap	forchap	PROPN
admet-275	373	7	,	,	PUNCT
admet-275	373	8	m.	m.	NOUN
admet-275	373	9	pirmohamed	pirmohamed	PROPN
admet-275	373	10	,	,	PUNCT
admet-275	373	11	r.e	r.e	PROPN
admet-275	373	12	.	.	PROPN
admet-275	373	13	clark	clark	PROPN
admet-275	373	14	,	,	PUNCT
admet-275	373	15	leukemia	leukemia	PROPN
admet-275	373	16	26(3	26(3	NUM
admet-275	373	17	)	)	PUNCT
admet-275	373	18	(	(	PUNCT
admet-275	373	19	2012	2012	NUM
admet-275	373	20	)	)	PUNCT
admet-275	373	21	490–498	490–498	NUM
admet-275	373	22	.	.	PUNCT
admet-275	374	1	©	©	PROPN
admet-275	374	2	2016	2016	NUM
admet-275	374	3	by	by	ADP
admet-275	374	4	the	the	DET
admet-275	374	5	authors	author	NOUN
admet-275	374	6	;	;	PUNCT
admet-275	374	7	licensee	licensee	PROPN
admet-275	374	8	iapc	iapc	PROPN
admet-275	374	9	,	,	PUNCT
admet-275	374	10	zagreb	zagreb	PROPN
admet-275	374	11	,	,	PUNCT
admet-275	374	12	croatia	croatia	PROPN
admet-275	374	13	.	.	PUNCT
admet-275	375	1	this	this	DET
admet-275	375	2	article	article	NOUN
admet-275	375	3	is	be	AUX
admet-275	375	4	an	an	DET
admet-275	375	5	open	open	ADJ
admet-275	375	6	-	-	PUNCT
admet-275	375	7	access	access	NOUN
admet-275	375	8	article	article	NOUN
admet-275	375	9	distributed	distribute	VERB
admet-275	375	10	under	under	ADP
admet-275	375	11	the	the	DET
admet-275	375	12	terms	term	NOUN
admet-275	375	13	and	and	CCONJ
admet-275	375	14	conditions	condition	NOUN
admet-275	375	15	of	of	ADP
admet-275	375	16	the	the	DET
admet-275	375	17	creative	creative	ADJ
admet-275	375	18	commons	common	NOUN
admet-275	375	19	attribution	attribution	NOUN
admet-275	375	20	license	license	NOUN
admet-275	375	21	(	(	PUNCT
admet-275	375	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-275	375	23	)	)	PUNCT
admet-275	375	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN