id	sid	tid	token	lemma	pos
admet-2753	1	1	comparison	comparison	NOUN
admet-2753	1	2	of	of	ADP
admet-2753	1	3	lipophilic	lipophilic	ADJ
admet-2753	1	4	and	and	CCONJ
admet-2753	1	5	size	size	NOUN
admet-2753	1	6	-	-	PUNCT
admet-2753	1	7	exclusion	exclusion	NOUN
admet-2753	1	8	membranes	membrane	NOUN
admet-2753	1	9	:	:	PUNCT
admet-2753	1	10	the	the	DET
admet-2753	1	11	effect	effect	NOUN
admet-2753	1	12	of	of	ADP
admet-2753	1	13	stirring	stirring	NOUN
admet-2753	1	14	and	and	CCONJ
admet-2753	1	15	cyclodextrin	cyclodextrin	NOUN
admet-2753	1	16	in	in	ADP
admet-2753	1	17	the	the	DET
admet-2753	1	18	donor	donor	NOUN
admet-2753	1	19	compartment	compartment	NOUN
admet-2753	1	20	doi	doi	NOUN
admet-2753	1	21	:	:	PUNCT
admet-2753	1	22	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	1	23	1	1	NUM
admet-2753	1	24	admet	admet	X
admet-2753	1	25	&	&	CCONJ
admet-2753	1	26	dmpk	dmpk	PROPN
admet-2753	1	27	13(4	13(4	NUM
admet-2753	1	28	)	)	PUNCT
admet-2753	1	29	(	(	PUNCT
admet-2753	1	30	2025	2025	NUM
admet-2753	1	31	)	)	PUNCT
admet-2753	1	32	2753	2753	NUM
admet-2753	1	33	;	;	PUNCT
admet-2753	1	34	doi	doi	NOUN
admet-2753	1	35	:	:	PUNCT
admet-2753	1	36	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	1	37	open	open	ADJ
admet-2753	1	38	access	access	NOUN
admet-2753	1	39	:	:	PUNCT
admet-2753	1	40	issn	issn	PROPN
admet-2753	1	41	:	:	PUNCT
admet-2753	1	42	1848	1848	NUM
admet-2753	1	43	-	-	SYM
admet-2753	1	44	7718	7718	NUM
admet-2753	1	45	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2753	1	46	original	original	ADJ
admet-2753	1	47	scientific	scientific	ADJ
admet-2753	1	48	paper	paper	NOUN
admet-2753	1	49	comparison	comparison	NOUN
admet-2753	1	50	of	of	ADP
admet-2753	1	51	lipophilic	lipophilic	ADJ
admet-2753	1	52	and	and	CCONJ
admet-2753	1	53	size	size	NOUN
admet-2753	1	54	-	-	PUNCT
admet-2753	1	55	exclusion	exclusion	NOUN
admet-2753	1	56	membranes	membrane	NOUN
admet-2753	1	57	:	:	PUNCT
admet-2753	1	58	the	the	DET
admet-2753	1	59	effect	effect	NOUN
admet-2753	1	60	of	of	ADP
admet-2753	1	61	stirring	stirring	NOUN
admet-2753	1	62	and	and	CCONJ
admet-2753	1	63	cyclodextrin	cyclodextrin	NOUN
admet-2753	1	64	in	in	ADP
admet-2753	1	65	the	the	DET
admet-2753	1	66	donor	donor	NOUN
admet-2753	1	67	compartment	compartment	NOUN
admet-2753	1	68	petra	petra	PROPN
admet-2753	1	69	tőzsér1	tőzsér1	PROPN
admet-2753	1	70	,	,	PUNCT
admet-2753	1	71	szabina	szabina	PROPN
admet-2753	1	72	kádár1	kádár1	PROPN
admet-2753	1	73	,	,	PUNCT
admet-2753	1	74	edina	edina	PROPN
admet-2753	1	75	szabó1	szabó1	PROPN
admet-2753	1	76	,	,	PUNCT
admet-2753	1	77	máté	máté	ADJ
admet-2753	1	78	dobó2	dobó2	PROPN
admet-2753	1	79	,	,	PUNCT
admet-2753	1	80	gergő	gergő	PROPN
admet-2753	1	81	tóth2	tóth2	PROPN
admet-2753	1	82	,	,	PUNCT
admet-2753	1	83	györgy	györgy	NOUN
admet-2753	1	84	t.	t.	PROPN
admet-2753	1	85	balogh2,3,4	balogh2,3,4	ADJ
admet-2753	1	86	,	,	PUNCT
admet-2753	1	87	péter	péter	NOUN
admet-2753	1	88	sóti5	sóti5	PROPN
admet-2753	1	89	,	,	PUNCT
admet-2753	1	90	bálint	bálint	PROPN
admet-2753	1	91	sinkó6	sinkó6	PROPN
admet-2753	1	92	and	and	CCONJ
admet-2753	1	93	enikő	enikő	PROPN
admet-2753	1	94	borbás1	borbás1	PROPN
admet-2753	1	95	,	,	PUNCT
admet-2753	1	96	*	*	PROPN
admet-2753	1	97	1department	1department	NUM
admet-2753	1	98	of	of	ADP
admet-2753	1	99	organic	organic	ADJ
admet-2753	1	100	chemistry	chemistry	NOUN
admet-2753	1	101	and	and	CCONJ
admet-2753	1	102	technology	technology	NOUN
admet-2753	1	103	,	,	PUNCT
admet-2753	1	104	faculty	faculty	NOUN
admet-2753	1	105	of	of	ADP
admet-2753	1	106	chemical	chemical	ADJ
admet-2753	1	107	technology	technology	NOUN
admet-2753	1	108	and	and	CCONJ
admet-2753	1	109	biotechnology	biotechnology	NOUN
admet-2753	1	110	,	,	PUNCT
admet-2753	1	111	budapest	budapest	PROPN
admet-2753	1	112	university	university	PROPN
admet-2753	1	113	of	of	ADP
admet-2753	1	114	technology	technology	NOUN
admet-2753	1	115	and	and	CCONJ
admet-2753	1	116	economics	economic	NOUN
admet-2753	1	117	,	,	PUNCT
admet-2753	1	118	3	3	NUM
admet-2753	1	119	műegyetem	műegyetem	NOUN
admet-2753	1	120	quay	quay	NOUN
admet-2753	1	121	,	,	PUNCT
admet-2753	1	122	h-1111	h-1111	PROPN
admet-2753	1	123	,	,	PUNCT
admet-2753	1	124	budapest	budapest	PROPN
admet-2753	1	125	,	,	PUNCT
admet-2753	1	126	hungary	hungary	PROPN
admet-2753	1	127	2department	2department	NUM
admet-2753	1	128	of	of	ADP
admet-2753	1	129	pharmaceutical	pharmaceutical	ADJ
admet-2753	1	130	chemistry	chemistry	NOUN
admet-2753	1	131	,	,	PUNCT
admet-2753	1	132	faculty	faculty	NOUN
admet-2753	1	133	of	of	ADP
admet-2753	1	134	pharmaceutical	pharmaceutical	NOUN
admet-2753	1	135	sciences	science	NOUN
admet-2753	1	136	,	,	PUNCT
admet-2753	1	137	semmelweis	semmelweis	NOUN
admet-2753	1	138	university	university	NOUN
admet-2753	1	139	,	,	PUNCT
admet-2753	1	140	9	9	NUM
admet-2753	1	141	hőgyes	hőgyes	PROPN
admet-2753	1	142	endre	endre	PROPN
admet-2753	1	143	street	street	PROPN
admet-2753	1	144	.	.	PUNCT
admet-2753	1	145	,	,	PUNCT
admet-2753	1	146	h-1092	h-1092	PROPN
admet-2753	1	147	,	,	PUNCT
admet-2753	1	148	budapest	budapest	NOUN
admet-2753	1	149	,	,	PUNCT
admet-2753	1	150	hungary	hungary	PROPN
admet-2753	1	151	3center	3center	NUM
admet-2753	1	152	for	for	ADP
admet-2753	1	153	pharmacology	pharmacology	NOUN
admet-2753	1	154	and	and	CCONJ
admet-2753	1	155	drug	drug	NOUN
admet-2753	1	156	research	research	PROPN
admet-2753	1	157	&	&	CCONJ
admet-2753	1	158	development	development	PROPN
admet-2753	1	159	,	,	PUNCT
admet-2753	1	160	semmelweis	semmelweis	NOUN
admet-2753	1	161	university	university	NOUN
admet-2753	1	162	,	,	PUNCT
admet-2753	1	163	26	26	NUM
admet-2753	1	164	üllői	üllői	PROPN
admet-2753	1	165	street	street	NOUN
admet-2753	1	166	.	.	PUNCT
admet-2753	1	167	,	,	PUNCT
admet-2753	2	1	h-1085	h-1085	PROPN
admet-2753	2	2	,	,	PUNCT
admet-2753	2	3	budapest	budapest	NOUN
admet-2753	2	4	,	,	PUNCT
admet-2753	2	5	hungary	hungary	PROPN
admet-2753	2	6	4department	4department	NUM
admet-2753	2	7	of	of	ADP
admet-2753	2	8	chemical	chemical	ADJ
admet-2753	2	9	and	and	CCONJ
admet-2753	2	10	environmental	environmental	ADJ
admet-2753	2	11	process	process	NOUN
admet-2753	2	12	engineering	engineering	NOUN
admet-2753	2	13	,	,	PUNCT
admet-2753	2	14	faculty	faculty	NOUN
admet-2753	2	15	of	of	ADP
admet-2753	2	16	chemical	chemical	ADJ
admet-2753	2	17	technology	technology	NOUN
admet-2753	2	18	and	and	CCONJ
admet-2753	2	19	biotechnology	biotechnology	NOUN
admet-2753	2	20	,	,	PUNCT
admet-2753	2	21	budapest	budapest	PROPN
admet-2753	2	22	university	university	PROPN
admet-2753	2	23	of	of	ADP
admet-2753	2	24	technology	technology	NOUN
admet-2753	2	25	and	and	CCONJ
admet-2753	2	26	economics	economic	NOUN
admet-2753	2	27	,	,	PUNCT
admet-2753	2	28	3	3	NUM
admet-2753	2	29	műegyetem	műegyetem	NOUN
admet-2753	2	30	quay	quay	NOUN
admet-2753	2	31	.	.	PUNCT
admet-2753	2	32	,	,	PUNCT
admet-2753	2	33	h-1111	h-1111	PROPN
admet-2753	2	34	,	,	PUNCT
admet-2753	2	35	budapest	budapest	PROPN
admet-2753	2	36	,	,	PUNCT
admet-2753	2	37	hungary	hungary	PROPN
admet-2753	2	38	5lavet	5lavet	NUM
admet-2753	2	39	pharmaceutical	pharmaceutical	PROPN
admet-2753	2	40	ltd	ltd	PROPN
admet-2753	2	41	.	.	PROPN
admet-2753	2	42	,	,	PUNCT
admet-2753	2	43	6	6	NUM
admet-2753	2	44	batthyány	batthyány	PROPN
admet-2753	2	45	street	street	PROPN
admet-2753	2	46	.	.	PUNCT
admet-2753	2	47	,	,	PUNCT
admet-2753	2	48	h-2143	h-2143	PROPN
admet-2753	2	49	,	,	PUNCT
admet-2753	2	50	kistarcsa	kistarcsa	NOUN
admet-2753	2	51	,	,	PUNCT
admet-2753	2	52	hungary	hungary	PROPN
admet-2753	2	53	6pion	6pion	PROPN
admet-2753	2	54	inc	inc	PROPN
admet-2753	2	55	.	.	PROPN
admet-2753	2	56	,	,	PUNCT
admet-2753	2	57	billerica	billerica	PROPN
admet-2753	2	58	,	,	PUNCT
admet-2753	2	59	10	10	NUM
admet-2753	2	60	cook	cook	PROPN
admet-2753	2	61	street	street	PROPN
admet-2753	2	62	,	,	PUNCT
admet-2753	2	63	massachusetts	massachusetts	PROPN
admet-2753	2	64	01821	01821	NUM
admet-2753	2	65	,	,	PUNCT
admet-2753	2	66	usa	usa	PROPN
admet-2753	2	67	corresponding	corresponding	PROPN
admet-2753	2	68	author	author	NOUN
admet-2753	2	69	:	:	PUNCT
admet-2753	2	70	e	e	NOUN
admet-2753	2	71	-	-	NOUN
admet-2753	2	72	mail	mail	NOUN
admet-2753	2	73	:	:	PUNCT
admet-2753	2	74	*	*	PUNCT
admet-2753	2	75	eniko.jaksaneborbas@edu.bme.hu	eniko.jaksaneborbas@edu.bme.hu	X
admet-2753	2	76	;	;	PUNCT
admet-2753	2	77	tel	tel	PROPN
admet-2753	2	78	.	.	PUNCT
admet-2753	2	79	:	:	PUNCT
admet-2753	2	80	+36	+36	NUM
admet-2753	2	81	-	-	SYM
admet-2753	2	82	307273966	307273966	NUM
admet-2753	2	83	;	;	PUNCT
admet-2753	2	84	fax	fax	NOUN
admet-2753	2	85	:	:	PUNCT
admet-2753	2	86	+36	+36	NUM
admet-2753	2	87	-	-	SYM
admet-2753	2	88	307273966	307273966	NUM
admet-2753	2	89	received	receive	VERB
admet-2753	2	90	:	:	PUNCT
admet-2753	2	91	april	april	PROPN
admet-2753	2	92	01	01	NUM
admet-2753	2	93	,	,	PUNCT
admet-2753	2	94	2025	2025	NUM
admet-2753	2	95	;	;	PUNCT
admet-2753	2	96	revised	revise	VERB
admet-2753	2	97	:	:	PUNCT
admet-2753	2	98	june	june	PROPN
admet-2753	2	99	22	22	NUM
admet-2753	2	100	,	,	PUNCT
admet-2753	2	101	2025	2025	NUM
admet-2753	2	102	;	;	PUNCT
admet-2753	2	103	published	publish	VERB
admet-2753	2	104	:	:	PUNCT
admet-2753	2	105	july	july	PROPN
admet-2753	2	106	5	5	NUM
admet-2753	2	107	,	,	PUNCT
admet-2753	2	108	2025	2025	NUM
admet-2753	2	109	abstract	abstract	ADJ
admet-2753	2	110	background	background	NOUN
admet-2753	2	111	and	and	CCONJ
admet-2753	2	112	purpose	purpose	NOUN
admet-2753	2	113	:	:	PUNCT
admet-2753	2	114	the	the	DET
admet-2753	2	115	effective	effective	ADJ
admet-2753	2	116	transport	transport	NOUN
admet-2753	2	117	of	of	ADP
admet-2753	2	118	an	an	DET
admet-2753	2	119	active	active	ADJ
admet-2753	2	120	pharmaceutical	pharmaceutical	ADJ
admet-2753	2	121	ingredient	ingredient	NOUN
admet-2753	2	122	across	across	ADP
admet-2753	2	123	various	various	ADJ
admet-2753	2	124	membrane	membrane	NOUN
admet-2753	2	125	systems	system	NOUN
admet-2753	2	126	is	be	AUX
admet-2753	2	127	critical	critical	ADJ
admet-2753	2	128	for	for	ADP
admet-2753	2	129	enhancing	enhance	VERB
admet-2753	2	130	its	its	PRON
admet-2753	2	131	bioavailability	bioavailability	NOUN
admet-2753	2	132	,	,	PUNCT
admet-2753	2	133	especially	especially	ADV
admet-2753	2	134	in	in	ADP
admet-2753	2	135	formulations	formulation	NOUN
admet-2753	2	136	involving	involve	VERB
admet-2753	2	137	solubilizing	solubilize	VERB
admet-2753	2	138	agents	agent	NOUN
admet-2753	2	139	.	.	PUNCT
admet-2753	3	1	this	this	DET
admet-2753	3	2	study	study	NOUN
admet-2753	3	3	aims	aim	VERB
admet-2753	3	4	to	to	PART
admet-2753	3	5	investigate	investigate	VERB
admet-2753	3	6	the	the	DET
admet-2753	3	7	permeability	permeability	NOUN
admet-2753	3	8	differences	difference	NOUN
admet-2753	3	9	of	of	ADP
admet-2753	3	10	carvedilol	carvedilol	NOUN
admet-2753	3	11	(	(	PUNCT
admet-2753	3	12	car	car	NOUN
admet-2753	3	13	)	)	PUNCT
admet-2753	3	14	between	between	ADP
admet-2753	3	15	lipophilic	lipophilic	NOUN
admet-2753	3	16	and	and	CCONJ
admet-2753	3	17	size	size	NOUN
admet-2753	3	18	-	-	PUNCT
admet-2753	3	19	exclusion	exclusion	NOUN
admet-2753	3	20	membranes	membrane	NOUN
admet-2753	3	21	in	in	ADP
admet-2753	3	22	the	the	DET
admet-2753	3	23	presence	presence	NOUN
admet-2753	3	24	of	of	ADP
admet-2753	3	25	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	3	26	-	-	PUNCT
admet-2753	3	27	beta	beta	NOUN
admet-2753	3	28	-	-	PUNCT
admet-2753	3	29	cyclodextrin	cyclodextrin	NOUN
admet-2753	3	30	(	(	PUNCT
admet-2753	3	31	hp	hp	PROPN
admet-2753	3	32	-	-	PUNCT
admet-2753	3	33	β	β	NOUN
admet-2753	3	34	-	-	NOUN
admet-2753	3	35	cd	cd	NOUN
admet-2753	3	36	)	)	PUNCT
admet-2753	3	37	using	use	VERB
admet-2753	3	38	in	in	ADP
admet-2753	3	39	vitro	vitro	X
admet-2753	3	40	sideby	sideby	ADJ
admet-2753	3	41	-	-	PUNCT
admet-2753	3	42	side	side	NOUN
admet-2753	3	43	diffusion	diffusion	NOUN
admet-2753	3	44	cell	cell	NOUN
admet-2753	3	45	assays	assay	NOUN
admet-2753	3	46	.	.	PUNCT
admet-2753	4	1	experimental	experimental	ADJ
admet-2753	4	2	approach	approach	NOUN
admet-2753	4	3	:	:	PUNCT
admet-2753	4	4	solubility	solubility	NOUN
admet-2753	4	5	and	and	CCONJ
admet-2753	4	6	permeability	permeability	NOUN
admet-2753	4	7	assays	assay	NOUN
admet-2753	4	8	confirmed	confirm	VERB
admet-2753	4	9	that	that	SCONJ
admet-2753	4	10	hpβ	hpβ	PROPN
admet-2753	4	11	-	-	PUNCT
admet-2753	4	12	cd	cd	NOUN
admet-2753	4	13	significantly	significantly	ADV
admet-2753	4	14	enhanced	enhance	VERB
admet-2753	4	15	the	the	DET
admet-2753	4	16	solubility	solubility	NOUN
admet-2753	4	17	of	of	ADP
admet-2753	4	18	car	car	NOUN
admet-2753	4	19	,	,	PUNCT
admet-2753	4	20	while	while	SCONJ
admet-2753	4	21	simultaneously	simultaneously	ADV
admet-2753	4	22	decreasing	decrease	VERB
admet-2753	4	23	its	its	PRON
admet-2753	4	24	permeability	permeability	NOUN
admet-2753	4	25	,	,	PUNCT
admet-2753	4	26	indicating	indicate	VERB
admet-2753	4	27	an	an	DET
admet-2753	4	28	interplay	interplay	NOUN
admet-2753	4	29	between	between	ADP
admet-2753	4	30	the	the	DET
admet-2753	4	31	two	two	NUM
admet-2753	4	32	parameters	parameter	NOUN
admet-2753	4	33	.	.	PUNCT
admet-2753	5	1	key	key	ADJ
admet-2753	5	2	results	result	NOUN
admet-2753	5	3	:	:	PUNCT
admet-2753	5	4	a	a	DET
admet-2753	5	5	mathematical	mathematical	ADJ
admet-2753	5	6	model	model	NOUN
admet-2753	5	7	based	base	VERB
admet-2753	5	8	on	on	ADP
admet-2753	5	9	fick	fick	PROPN
admet-2753	5	10	’s	’s	PART
admet-2753	5	11	first	first	ADJ
admet-2753	5	12	law	law	NOUN
admet-2753	5	13	of	of	ADP
admet-2753	5	14	diffusion	diffusion	NOUN
admet-2753	5	15	was	be	AUX
admet-2753	5	16	developed	develop	VERB
admet-2753	5	17	to	to	PART
admet-2753	5	18	describe	describe	VERB
admet-2753	5	19	drug	drug	NOUN
admet-2753	5	20	transport	transport	NOUN
admet-2753	5	21	across	across	ADP
admet-2753	5	22	the	the	DET
admet-2753	5	23	uwl	uwl	NOUN
admet-2753	5	24	,	,	PUNCT
admet-2753	5	25	and	and	CCONJ
admet-2753	5	26	generally	generally	ADV
admet-2753	5	27	through	through	ADP
admet-2753	5	28	the	the	DET
admet-2753	5	29	uwlmembrane	uwlmembrane	ADJ
admet-2753	5	30	system	system	NOUN
admet-2753	5	31	,	,	PUNCT
admet-2753	5	32	with	with	ADP
admet-2753	5	33	a	a	DET
admet-2753	5	34	particular	particular	ADJ
admet-2753	5	35	focus	focus	NOUN
admet-2753	5	36	on	on	ADP
admet-2753	5	37	the	the	DET
admet-2753	5	38	role	role	NOUN
admet-2753	5	39	of	of	ADP
admet-2753	5	40	solubilizing	solubilize	VERB
admet-2753	5	41	agents	agent	NOUN
admet-2753	5	42	.	.	PUNCT
admet-2753	6	1	conclusion	conclusion	NOUN
admet-2753	6	2	:	:	PUNCT
admet-2753	6	3	results	result	NOUN
admet-2753	6	4	from	from	ADP
admet-2753	6	5	both	both	CCONJ
admet-2753	6	6	the	the	DET
admet-2753	6	7	uwl	uwl	NOUN
admet-2753	6	8	and	and	CCONJ
admet-2753	6	9	membrane	membrane	NOUN
admet-2753	6	10	limited	limited	ADJ
admet-2753	6	11	transport	transport	NOUN
admet-2753	6	12	conditions	condition	NOUN
admet-2753	6	13	demonstrated	demonstrate	VERB
admet-2753	6	14	that	that	SCONJ
admet-2753	6	15	the	the	DET
admet-2753	6	16	supersaturation	supersaturation	NOUN
admet-2753	6	17	ratio	ratio	NOUN
admet-2753	6	18	(	(	PUNCT
admet-2753	6	19	ssr	ssr	PROPN
admet-2753	6	20	,	,	PUNCT
admet-2753	6	21	defined	define	VERB
admet-2753	6	22	as	as	ADP
admet-2753	6	23	the	the	DET
admet-2753	6	24	ratio	ratio	NOUN
admet-2753	6	25	of	of	ADP
admet-2753	6	26	the	the	DET
admet-2753	6	27	drug	drug	NOUN
admet-2753	6	28	concentration	concentration	NOUN
admet-2753	6	29	present	present	ADJ
admet-2753	6	30	in	in	ADP
admet-2753	6	31	solution	solution	NOUN
admet-2753	6	32	to	to	ADP
admet-2753	6	33	its	its	PRON
admet-2753	6	34	thermodynamic	thermodynamic	ADJ
admet-2753	6	35	solubility	solubility	NOUN
admet-2753	6	36	measured	measure	VERB
admet-2753	6	37	in	in	ADP
admet-2753	6	38	exactly	exactly	ADV
admet-2753	6	39	the	the	DET
admet-2753	6	40	same	same	ADJ
admet-2753	6	41	media	medium	NOUN
admet-2753	6	42	)	)	PUNCT
admet-2753	6	43	between	between	ADP
admet-2753	6	44	donor	donor	NOUN
admet-2753	6	45	and	and	CCONJ
admet-2753	6	46	acceptor	acceptor	NOUN
admet-2753	6	47	compartments	compartment	NOUN
admet-2753	6	48	is	be	AUX
admet-2753	6	49	the	the	DET
admet-2753	6	50	real	real	ADJ
admet-2753	6	51	driving	drive	VERB
admet-2753	6	52	force	force	NOUN
admet-2753	6	53	of	of	ADP
admet-2753	6	54	the	the	DET
admet-2753	6	55	transport	transport	NOUN
admet-2753	6	56	,	,	PUNCT
admet-2753	6	57	when	when	SCONJ
admet-2753	6	58	the	the	DET
admet-2753	6	59	complexing	complexe	VERB
admet-2753	6	60	agent	agent	NOUN
admet-2753	6	61	and	and	CCONJ
admet-2753	6	62	the	the	DET
admet-2753	6	63	drughp	drughp	PROPN
admet-2753	6	64	-	-	PUNCT
admet-2753	6	65	β	β	NOUN
admet-2753	6	66	-	-	ADJ
admet-2753	6	67	cd	cd	ADJ
admet-2753	6	68	complex	complex	NOUN
admet-2753	6	69	does	do	AUX
admet-2753	6	70	not	not	PART
admet-2753	6	71	penetrate	penetrate	VERB
admet-2753	6	72	the	the	DET
admet-2753	6	73	membrane	membrane	NOUN
admet-2753	6	74	or	or	CCONJ
admet-2753	6	75	the	the	DET
admet-2753	6	76	permeation	permeation	NOUN
admet-2753	6	77	of	of	ADP
admet-2753	6	78	the	the	DET
admet-2753	6	79	solubilizing	solubilizing	NOUN
admet-2753	6	80	additive	additive	NOUN
admet-2753	6	81	through	through	ADP
admet-2753	6	82	the	the	DET
admet-2753	6	83	membrane	membrane	NOUN
admet-2753	6	84	is	be	AUX
admet-2753	6	85	relatively	relatively	ADV
admet-2753	6	86	slow	slow	ADJ
admet-2753	6	87	,	,	PUNCT
admet-2753	6	88	so	so	CCONJ
admet-2753	6	89	it	it	PRON
admet-2753	6	90	does	do	AUX
admet-2753	6	91	not	not	PART
admet-2753	6	92	affect	affect	VERB
admet-2753	6	93	the	the	DET
admet-2753	6	94	transport	transport	NOUN
admet-2753	6	95	of	of	ADP
admet-2753	6	96	the	the	DET
admet-2753	6	97	api	api	NOUN
admet-2753	6	98	substantially	substantially	ADV
admet-2753	6	99	.	.	PUNCT
admet-2753	7	1	©	©	PROPN
admet-2753	7	2	2025	2025	NUM
admet-2753	7	3	by	by	ADP
admet-2753	7	4	the	the	DET
admet-2753	7	5	authors	author	NOUN
admet-2753	7	6	.	.	PUNCT
admet-2753	8	1	this	this	DET
admet-2753	8	2	article	article	NOUN
admet-2753	8	3	is	be	AUX
admet-2753	8	4	an	an	DET
admet-2753	8	5	open	open	ADJ
admet-2753	8	6	-	-	PUNCT
admet-2753	8	7	access	access	NOUN
admet-2753	8	8	article	article	NOUN
admet-2753	8	9	distributed	distribute	VERB
admet-2753	8	10	under	under	ADP
admet-2753	8	11	the	the	DET
admet-2753	8	12	terms	term	NOUN
admet-2753	8	13	and	and	CCONJ
admet-2753	8	14	conditions	condition	NOUN
admet-2753	8	15	of	of	ADP
admet-2753	8	16	the	the	DET
admet-2753	8	17	creative	creative	ADJ
admet-2753	8	18	commons	common	NOUN
admet-2753	8	19	attribution	attribution	NOUN
admet-2753	8	20	license	license	NOUN
admet-2753	8	21	(	(	PUNCT
admet-2753	8	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2753	8	23	)	)	PUNCT
admet-2753	8	24	.	.	PUNCT
admet-2753	9	1	keywords	keyword	VERB
admet-2753	9	2	unstirred	unstirred	ADJ
admet-2753	9	3	water	water	NOUN
admet-2753	9	4	layer	layer	NOUN
admet-2753	9	5	,	,	PUNCT
admet-2753	9	6	membrane	membrane	NOUN
admet-2753	9	7	transport	transport	NOUN
admet-2753	9	8	,	,	PUNCT
admet-2753	9	9	solubility	solubility	NOUN
admet-2753	9	10	,	,	PUNCT
admet-2753	9	11	supersaturation	supersaturation	NOUN
admet-2753	9	12	ratio	ratio	NOUN
admet-2753	9	13	,	,	PUNCT
admet-2753	9	14	carvedilol	carvedilol	PROPN
admet-2753	9	15	introduction	introduction	NOUN
admet-2753	9	16	over	over	ADP
admet-2753	9	17	the	the	DET
admet-2753	9	18	last	last	ADJ
admet-2753	9	19	decade	decade	NOUN
admet-2753	9	20	,	,	PUNCT
admet-2753	9	21	the	the	DET
admet-2753	9	22	evaluation	evaluation	NOUN
admet-2753	9	23	of	of	ADP
admet-2753	9	24	intestinal	intestinal	ADJ
admet-2753	9	25	drug	drug	NOUN
admet-2753	9	26	permeation	permeation	NOUN
admet-2753	9	27	using	use	VERB
admet-2753	9	28	in	in	ADP
admet-2753	9	29	vitro	vitro	X
admet-2753	9	30	systems	system	NOUN
admet-2753	9	31	has	have	AUX
admet-2753	9	32	gained	gain	VERB
admet-2753	9	33	focus	focus	NOUN
admet-2753	9	34	,	,	PUNCT
admet-2753	9	35	leading	lead	VERB
admet-2753	9	36	to	to	ADP
admet-2753	9	37	the	the	DET
admet-2753	9	38	development	development	NOUN
admet-2753	9	39	of	of	ADP
admet-2753	9	40	numerous	numerous	ADJ
admet-2753	9	41	new	new	ADJ
admet-2753	9	42	cell	cell	NOUN
admet-2753	9	43	-	-	PUNCT
admet-2753	9	44	free	free	ADJ
admet-2753	9	45	permeation	permeation	NOUN
admet-2753	9	46	tools	tool	NOUN
admet-2753	9	47	.	.	PUNCT
admet-2753	10	1	despite	despite	SCONJ
admet-2753	10	2	the	the	DET
admet-2753	10	3	great	great	ADJ
admet-2753	10	4	interest	interest	NOUN
admet-2753	10	5	in	in	ADP
admet-2753	10	6	intestinal	intestinal	ADJ
admet-2753	10	7	tissue	tissue	NOUN
admet-2753	10	8	or	or	CCONJ
admet-2753	10	9	cell	cell	NOUN
admet-2753	10	10	layers	layer	NOUN
admet-2753	10	11	to	to	PART
admet-2753	10	12	investigate	investigate	VERB
admet-2753	10	13	the	the	DET
admet-2753	10	14	intestinal	intestinal	ADJ
admet-2753	10	15	permeation	permeation	NOUN
admet-2753	10	16	potential	potential	NOUN
admet-2753	10	17	of	of	ADP
admet-2753	10	18	drug	drug	NOUN
admet-2753	10	19	compounds	compound	NOUN
admet-2753	10	20	,	,	PUNCT
admet-2753	10	21	their	their	PRON
admet-2753	10	22	application	application	NOUN
admet-2753	10	23	in	in	ADP
admet-2753	10	24	industrial	industrial	ADJ
admet-2753	10	25	laboratories	laboratory	NOUN
admet-2753	10	26	is	be	AUX
admet-2753	10	27	strongly	strongly	ADV
admet-2753	10	28	discouraged	discouraged	ADJ
admet-2753	10	29	and	and	CCONJ
admet-2753	10	30	complicated	complicated	ADJ
admet-2753	10	31	due	due	ADJ
admet-2753	10	32	to	to	ADP
admet-2753	10	33	lengthy	lengthy	ADJ
admet-2753	10	34	preparation	preparation	NOUN
admet-2753	10	35	steps	step	NOUN
admet-2753	10	36	.	.	PUNCT
admet-2753	11	1	while	while	SCONJ
admet-2753	11	2	cellhttps://doi.org/10.5599/admet.2753	cellhttps://doi.org/10.5599/admet.2753	NOUN
admet-2753	11	3	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	11	4	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2753	11	5	mailto:eniko.jaksaneborbas@edu.bme.hu	mailto:eniko.jaksaneborbas@edu.bme.hu	PROPN
admet-2753	11	6	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2753	11	7	p.	p.	PROPN
admet-2753	11	8	tőzsér	tőzsér	PROPN
admet-2753	11	9	et	et	PROPN
admet-2753	11	10	al	al	PROPN
admet-2753	11	11	.	.	PROPN
admet-2753	11	12	admet	admet	PROPN
admet-2753	11	13	&	&	CCONJ
admet-2753	11	14	dmpk	dmpk	PROPN
admet-2753	11	15	13(4	13(4	NUM
admet-2753	11	16	)	)	PUNCT
admet-2753	11	17	(	(	PUNCT
admet-2753	11	18	2025	2025	NUM
admet-2753	11	19	)	)	PUNCT
admet-2753	11	20	2753	2753	NUM
admet-2753	11	21	2	2	NUM
admet-2753	11	22	based	base	VERB
admet-2753	11	23	systems	system	NOUN
admet-2753	11	24	are	be	AUX
admet-2753	11	25	still	still	ADV
admet-2753	11	26	preferred	prefer	VERB
admet-2753	11	27	for	for	ADP
admet-2753	11	28	assessing	assess	VERB
admet-2753	11	29	the	the	DET
admet-2753	11	30	apparent	apparent	ADJ
admet-2753	11	31	drug	drug	NOUN
admet-2753	11	32	permeability	permeability	NOUN
admet-2753	11	33	coefficient	coefficient	NOUN
admet-2753	11	34	(	(	PUNCT
admet-2753	11	35	papp	papp	NOUN
admet-2753	11	36	)	)	PUNCT
admet-2753	11	37	,	,	PUNCT
admet-2753	11	38	there	there	PRON
admet-2753	11	39	is	be	VERB
admet-2753	11	40	a	a	DET
admet-2753	11	41	paradigm	paradigm	NOUN
admet-2753	11	42	shift	shift	NOUN
admet-2753	11	43	from	from	ADP
admet-2753	11	44	the	the	DET
admet-2753	11	45	traditional	traditional	ADJ
admet-2753	11	46	celland	celland	NOUN
admet-2753	11	47	tissue	tissue	NOUN
admet-2753	11	48	-	-	PUNCT
admet-2753	11	49	based	base	VERB
admet-2753	11	50	permeation	permeation	NOUN
admet-2753	11	51	barriers	barrier	NOUN
admet-2753	11	52	towards	towards	ADP
admet-2753	11	53	cell	cell	NOUN
admet-2753	11	54	-	-	PUNCT
admet-2753	11	55	free	free	ADJ
admet-2753	11	56	permeation	permeation	NOUN
admet-2753	11	57	barriers	barrier	NOUN
admet-2753	11	58	[	[	X
admet-2753	11	59	1	1	NUM
admet-2753	11	60	-	-	SYM
admet-2753	11	61	8	8	NUM
admet-2753	11	62	]	]	PUNCT
admet-2753	11	63	.	.	PUNCT
admet-2753	12	1	transport	transport	NOUN
admet-2753	12	2	through	through	ADP
admet-2753	12	3	the	the	DET
admet-2753	12	4	gut	gut	NOUN
admet-2753	12	5	wall	wall	NOUN
admet-2753	12	6	in	in	ADP
admet-2753	12	7	vivo	vivo	NOUN
admet-2753	12	8	and	and	CCONJ
admet-2753	12	9	through	through	ADP
admet-2753	12	10	the	the	DET
admet-2753	12	11	lipophilic	lipophilic	ADJ
admet-2753	12	12	membrane	membrane	NOUN
admet-2753	12	13	in	in	ADP
admet-2753	12	14	vitro	vitro	X
admet-2753	12	15	can	can	AUX
admet-2753	12	16	be	be	AUX
admet-2753	12	17	rate	rate	NOUN
admet-2753	12	18	-	-	PUNCT
admet-2753	12	19	limited	limit	VERB
admet-2753	12	20	by	by	ADP
admet-2753	12	21	the	the	DET
admet-2753	12	22	transport	transport	NOUN
admet-2753	12	23	through	through	ADP
admet-2753	12	24	the	the	DET
admet-2753	12	25	membrane	membrane	NOUN
admet-2753	12	26	(	(	PUNCT
admet-2753	12	27	epithelial	epithelial	ADJ
admet-2753	12	28	cell	cell	NOUN
admet-2753	12	29	membrane	membrane	NOUN
admet-2753	12	30	or	or	CCONJ
admet-2753	12	31	lipid	lipid	NOUN
admet-2753	12	32	layer	layer	NOUN
admet-2753	12	33	,	,	PUNCT
admet-2753	12	34	respectively	respectively	ADV
admet-2753	12	35	)	)	PUNCT
admet-2753	12	36	or	or	CCONJ
admet-2753	12	37	by	by	ADP
admet-2753	12	38	diffusion	diffusion	NOUN
admet-2753	12	39	through	through	ADP
admet-2753	12	40	the	the	DET
admet-2753	12	41	so	so	ADV
admet-2753	12	42	-	-	PUNCT
admet-2753	12	43	called	call	VERB
admet-2753	12	44	unstirred	unstirred	ADJ
admet-2753	12	45	water	water	NOUN
admet-2753	12	46	layer	layer	NOUN
admet-2753	12	47	(	(	PUNCT
admet-2753	12	48	uwl	uwl	NOUN
admet-2753	12	49	)	)	PUNCT
admet-2753	12	50	.	.	PUNCT
admet-2753	13	1	in	in	ADP
admet-2753	13	2	lipophilic	lipophilic	ADJ
admet-2753	13	3	active	active	ADJ
admet-2753	13	4	pharmaceutical	pharmaceutical	ADJ
admet-2753	13	5	ingredients	ingredient	NOUN
admet-2753	13	6	(	(	PUNCT
admet-2753	13	7	apis	apis	ADJ
admet-2753	13	8	)	)	PUNCT
admet-2753	13	9	,	,	PUNCT
admet-2753	13	10	cellular	cellular	ADJ
admet-2753	13	11	membrane	membrane	NOUN
admet-2753	13	12	permeation	permeation	NOUN
admet-2753	13	13	is	be	AUX
admet-2753	13	14	very	very	ADV
admet-2753	13	15	fast	fast	ADJ
admet-2753	13	16	and	and	CCONJ
admet-2753	13	17	permeation	permeation	NOUN
admet-2753	13	18	through	through	ADP
admet-2753	13	19	the	the	DET
admet-2753	13	20	ca	ca	NOUN
admet-2753	13	21	.	.	PUNCT
admet-2753	14	1	300	300	NUM
admet-2753	14	2	µm	µm	ADP
admet-2753	14	3	thick	thick	ADJ
admet-2753	14	4	uwl	uwl	NOUN
admet-2753	14	5	on	on	ADP
admet-2753	14	6	the	the	DET
admet-2753	14	7	apical	apical	ADJ
admet-2753	14	8	side	side	NOUN
admet-2753	14	9	of	of	ADP
admet-2753	14	10	the	the	DET
admet-2753	14	11	membrane	membrane	NOUN
admet-2753	14	12	becomes	become	VERB
admet-2753	14	13	the	the	DET
admet-2753	14	14	rate	rate	NOUN
admet-2753	14	15	-	-	PUNCT
admet-2753	14	16	limiting	limit	VERB
admet-2753	14	17	step	step	NOUN
admet-2753	14	18	of	of	ADP
admet-2753	14	19	the	the	DET
admet-2753	14	20	transport	transport	NOUN
admet-2753	14	21	in	in	ADP
admet-2753	14	22	vivo	vivo	NOUN
admet-2753	14	23	[	[	X
admet-2753	14	24	9,10	9,10	NUM
admet-2753	14	25	]	]	X
admet-2753	14	26	.	.	PUNCT
admet-2753	15	1	however	however	ADV
admet-2753	15	2	,	,	PUNCT
admet-2753	15	3	in	in	ADP
admet-2753	15	4	an	an	DET
admet-2753	15	5	in	in	ADP
admet-2753	15	6	vitro	vitro	X
admet-2753	15	7	permeability	permeability	NOUN
admet-2753	15	8	assay	assay	VERB
admet-2753	15	9	with	with	ADP
admet-2753	15	10	a	a	DET
admet-2753	15	11	planar	planar	ADJ
admet-2753	15	12	membrane	membrane	NOUN
admet-2753	15	13	,	,	PUNCT
admet-2753	15	14	the	the	DET
admet-2753	15	15	uwl	uwl	NOUN
admet-2753	15	16	can	can	AUX
admet-2753	15	17	be	be	AUX
admet-2753	15	18	up	up	ADP
admet-2753	15	19	to	to	ADP
admet-2753	15	20	1500	1500	NUM
admet-2753	15	21	to	to	ADP
admet-2753	15	22	4000	4000	NUM
admet-2753	15	23	μm	μm	NOUN
admet-2753	15	24	thick	thick	ADJ
admet-2753	15	25	in	in	ADP
admet-2753	15	26	non	non	ADJ
admet-2753	15	27	-	-	ADJ
admet-2753	15	28	stirred	stirred	ADJ
admet-2753	15	29	conditions	condition	NOUN
admet-2753	15	30	.	.	PUNCT
admet-2753	16	1	without	without	ADP
admet-2753	16	2	vigorous	vigorous	ADJ
admet-2753	16	3	stirring	stirring	NOUN
admet-2753	16	4	,	,	PUNCT
admet-2753	16	5	the	the	DET
admet-2753	16	6	uwl	uwl	PRON
admet-2753	16	7	usually	usually	ADV
admet-2753	16	8	dominates	dominate	VERB
admet-2753	16	9	the	the	DET
admet-2753	16	10	apparent	apparent	ADJ
admet-2753	16	11	permeability	permeability	NOUN
admet-2753	16	12	if	if	SCONJ
admet-2753	16	13	its	its	PRON
admet-2753	16	14	value	value	NOUN
admet-2753	16	15	exceeds	exceed	VERB
admet-2753	16	16	310	310	NUM
admet-2753	16	17	-	-	SYM
admet-2753	16	18	5	5	NUM
admet-2753	16	19	cm	cm	NUM
admet-2753	16	20	s-1	s-1	NOUN
admet-2753	16	21	.	.	PUNCT
admet-2753	17	1	in	in	ADP
admet-2753	17	2	case	case	NOUN
admet-2753	17	3	of	of	ADP
admet-2753	17	4	cellor	cellor	NOUN
admet-2753	17	5	tissue	tissue	NOUN
admet-2753	17	6	-	-	PUNCT
admet-2753	17	7	based	base	VERB
admet-2753	17	8	permeation	permeation	NOUN
admet-2753	17	9	barriers	barrier	NOUN
admet-2753	17	10	,	,	PUNCT
admet-2753	17	11	the	the	DET
admet-2753	17	12	use	use	NOUN
admet-2753	17	13	of	of	ADP
admet-2753	17	14	stirring	stir	VERB
admet-2753	17	15	negatively	negatively	ADV
admet-2753	17	16	affects	affect	VERB
admet-2753	17	17	the	the	DET
admet-2753	17	18	viability	viability	NOUN
admet-2753	17	19	of	of	ADP
admet-2753	17	20	the	the	DET
admet-2753	17	21	membrane	membrane	NOUN
admet-2753	17	22	,	,	PUNCT
admet-2753	17	23	therefore	therefore	ADV
admet-2753	17	24	,	,	PUNCT
admet-2753	17	25	vigorous	vigorous	ADJ
admet-2753	17	26	stirring	stirring	NOUN
admet-2753	17	27	can	can	AUX
admet-2753	17	28	not	not	PART
admet-2753	17	29	be	be	AUX
admet-2753	17	30	used	use	VERB
admet-2753	17	31	,	,	PUNCT
admet-2753	17	32	leading	lead	VERB
admet-2753	17	33	to	to	ADP
admet-2753	17	34	uwl	uwl	X
admet-2753	17	35	limited	limit	VERB
admet-2753	17	36	transport	transport	NOUN
admet-2753	17	37	conditions	condition	NOUN
admet-2753	17	38	even	even	ADV
admet-2753	17	39	if	if	SCONJ
admet-2753	17	40	it	it	PRON
admet-2753	17	41	is	be	AUX
admet-2753	17	42	not	not	PART
admet-2753	17	43	the	the	DET
admet-2753	17	44	case	case	NOUN
admet-2753	17	45	in	in	ADP
admet-2753	17	46	vivo	vivo	NOUN
admet-2753	17	47	.	.	PUNCT
admet-2753	18	1	for	for	ADP
admet-2753	18	2	cell	cell	NOUN
admet-2753	18	3	-	-	PUNCT
admet-2753	18	4	free	free	ADJ
admet-2753	18	5	setups	setup	NOUN
admet-2753	18	6	with	with	ADP
admet-2753	18	7	efficient	efficient	ADJ
admet-2753	18	8	stirring	stirring	NOUN
admet-2753	18	9	,	,	PUNCT
admet-2753	18	10	much	much	ADV
admet-2753	18	11	thinner	thin	ADJ
admet-2753	18	12	uwl	uwl	PRON
admet-2753	18	13	can	can	AUX
admet-2753	18	14	be	be	AUX
admet-2753	18	15	created	create	VERB
admet-2753	18	16	than	than	ADP
admet-2753	18	17	the	the	DET
admet-2753	18	18	approximated	approximate	VERB
admet-2753	18	19	thickness	thickness	NOUN
admet-2753	18	20	of	of	ADP
admet-2753	18	21	the	the	PRON
admet-2753	18	22	in	in	ADP
admet-2753	18	23	vivo	vivo	NOUN
admet-2753	18	24	uwl	uwl	NOUN
admet-2753	19	1	[	[	X
admet-2753	19	2	10	10	NUM
admet-2753	19	3	]	]	PUNCT
admet-2753	19	4	.	.	PUNCT
admet-2753	20	1	therefore	therefore	ADV
admet-2753	20	2	,	,	PUNCT
admet-2753	20	3	stirring	stir	VERB
admet-2753	20	4	such	such	ADJ
admet-2753	20	5	in	in	ADP
admet-2753	20	6	vitro	vitro	X
admet-2753	20	7	apparatuses	apparatus	NOUN
admet-2753	20	8	is	be	AUX
admet-2753	20	9	an	an	DET
admet-2753	20	10	important	important	ADJ
admet-2753	20	11	factor	factor	NOUN
admet-2753	20	12	and	and	CCONJ
admet-2753	20	13	must	must	AUX
admet-2753	20	14	be	be	AUX
admet-2753	20	15	investigated	investigate	VERB
admet-2753	20	16	.	.	PUNCT
admet-2753	21	1	artificial	artificial	ADJ
admet-2753	21	2	membranes	membrane	NOUN
admet-2753	21	3	based	base	VERB
admet-2753	21	4	on	on	ADP
admet-2753	21	5	filters	filter	NOUN
admet-2753	21	6	coated	coat	VERB
admet-2753	21	7	with	with	ADP
admet-2753	21	8	a	a	DET
admet-2753	21	9	phospholipid	phospholipid	NOUN
admet-2753	21	10	layer	layer	NOUN
admet-2753	21	11	[	[	X
admet-2753	21	12	11,12	11,12	NUM
admet-2753	21	13	]	]	PUNCT
admet-2753	21	14	are	be	AUX
admet-2753	21	15	widely	widely	ADV
admet-2753	21	16	used	use	VERB
admet-2753	21	17	in	in	ADP
admet-2753	21	18	pharmaceutical	pharmaceutical	ADJ
admet-2753	21	19	development	development	NOUN
admet-2753	21	20	to	to	PART
admet-2753	21	21	mimic	mimic	VERB
admet-2753	21	22	the	the	DET
admet-2753	21	23	in	in	ADP
admet-2753	21	24	vivo	vivo	ADJ
admet-2753	21	25	composition	composition	NOUN
admet-2753	21	26	of	of	ADP
admet-2753	21	27	the	the	DET
admet-2753	21	28	epithelium	epithelium	NOUN
admet-2753	21	29	layer	layer	NOUN
admet-2753	21	30	in	in	ADP
admet-2753	21	31	the	the	DET
admet-2753	21	32	gastrointestinal	gastrointestinal	ADJ
admet-2753	21	33	tract	tract	NOUN
admet-2753	21	34	(	(	PUNCT
admet-2753	21	35	git	git	NOUN
admet-2753	21	36	)	)	PUNCT
admet-2753	21	37	due	due	ADP
admet-2753	21	38	to	to	ADP
admet-2753	21	39	their	their	PRON
admet-2753	21	40	reasonably	reasonably	ADV
admet-2753	21	41	accurate	accurate	ADJ
admet-2753	21	42	predictive	predictive	ADJ
admet-2753	21	43	capabilities	capability	NOUN
admet-2753	21	44	in	in	ADP
admet-2753	21	45	case	case	NOUN
admet-2753	21	46	of	of	ADP
admet-2753	21	47	the	the	DET
admet-2753	21	48	permeability	permeability	NOUN
admet-2753	21	49	of	of	ADP
admet-2753	21	50	pure	pure	ADJ
admet-2753	21	51	apis	apis	NOUN
admet-2753	21	52	and	and	CCONJ
admet-2753	21	53	also	also	ADV
admet-2753	21	54	in	in	ADP
admet-2753	21	55	case	case	NOUN
admet-2753	21	56	of	of	ADP
admet-2753	21	57	the	the	DET
admet-2753	21	58	permeability	permeability	NOUN
admet-2753	21	59	assessment	assessment	NOUN
admet-2753	21	60	of	of	ADP
admet-2753	21	61	drug	drug	NOUN
admet-2753	21	62	formulations	formulation	NOUN
admet-2753	21	63	[	[	X
admet-2753	21	64	2,7,8,13	2,7,8,13	NUM
admet-2753	21	65	]	]	PUNCT
admet-2753	21	66	.	.	PUNCT
admet-2753	22	1	like	like	ADP
admet-2753	22	2	all	all	DET
admet-2753	22	3	models	model	NOUN
admet-2753	22	4	,	,	PUNCT
admet-2753	22	5	these	these	PRON
admet-2753	22	6	also	also	ADV
admet-2753	22	7	have	have	VERB
admet-2753	22	8	some	some	DET
admet-2753	22	9	disadvantages	disadvantage	NOUN
admet-2753	22	10	,	,	PUNCT
admet-2753	22	11	such	such	ADJ
admet-2753	22	12	as	as	ADP
admet-2753	22	13	the	the	DET
admet-2753	22	14	lipids	lipid	NOUN
admet-2753	22	15	being	be	AUX
admet-2753	22	16	stored	store	VERB
admet-2753	22	17	frozen	frozen	ADJ
admet-2753	22	18	and	and	CCONJ
admet-2753	22	19	potentially	potentially	ADV
admet-2753	22	20	being	be	AUX
admet-2753	22	21	chemically	chemically	ADV
admet-2753	22	22	incompatible	incompatible	ADJ
admet-2753	22	23	with	with	ADP
admet-2753	22	24	biological	biological	ADJ
admet-2753	22	25	gastrointestinal	gastrointestinal	ADJ
admet-2753	22	26	fluid	fluid	NOUN
admet-2753	22	27	[	[	X
admet-2753	22	28	14	14	NUM
admet-2753	22	29	]	]	PUNCT
admet-2753	22	30	or	or	CCONJ
admet-2753	22	31	with	with	ADP
admet-2753	22	32	lipid	lipid	NOUN
admet-2753	22	33	formulations	formulation	NOUN
admet-2753	22	34	where	where	SCONJ
admet-2753	22	35	the	the	DET
admet-2753	22	36	drug	drug	NOUN
admet-2753	22	37	can	can	AUX
admet-2753	22	38	be	be	AUX
admet-2753	22	39	dissolved	dissolve	VERB
admet-2753	22	40	in	in	ADP
admet-2753	22	41	a	a	DET
admet-2753	22	42	medium	medium	NOUN
admet-2753	22	43	containing	contain	VERB
admet-2753	22	44	enzymes	enzyme	NOUN
admet-2753	22	45	[	[	X
admet-2753	22	46	15	15	NUM
admet-2753	22	47	]	]	X
admet-2753	22	48	,	,	PUNCT
admet-2753	22	49	which	which	PRON
admet-2753	22	50	could	could	AUX
admet-2753	22	51	affect	affect	VERB
admet-2753	22	52	the	the	DET
admet-2753	22	53	integrity	integrity	NOUN
admet-2753	22	54	of	of	ADP
admet-2753	22	55	the	the	DET
admet-2753	22	56	lipophilic	lipophilic	ADJ
admet-2753	22	57	membrane	membrane	NOUN
admet-2753	22	58	.	.	PUNCT
admet-2753	23	1	size	size	NOUN
admet-2753	23	2	-	-	PUNCT
admet-2753	23	3	exclusion	exclusion	NOUN
admet-2753	23	4	membranes	membrane	NOUN
admet-2753	23	5	are	be	AUX
admet-2753	23	6	often	often	ADV
admet-2753	23	7	referred	refer	VERB
admet-2753	23	8	to	to	ADP
admet-2753	23	9	as	as	ADP
admet-2753	23	10	dialysis	dialysis	NOUN
admet-2753	23	11	membranes	membrane	NOUN
admet-2753	23	12	,	,	PUNCT
admet-2753	23	13	where	where	SCONJ
admet-2753	23	14	the	the	DET
admet-2753	23	15	pore	pore	ADJ
admet-2753	23	16	sizes	size	NOUN
admet-2753	23	17	of	of	ADP
admet-2753	23	18	the	the	DET
admet-2753	23	19	membrane	membrane	NOUN
admet-2753	23	20	are	be	AUX
admet-2753	23	21	below	below	ADP
admet-2753	23	22	2	2	NUM
admet-2753	23	23	to	to	ADP
admet-2753	23	24	5	5	NUM
admet-2753	23	25	nm	nm	NOUN
admet-2753	23	26	(	(	PUNCT
admet-2753	23	27	or	or	CCONJ
admet-2753	23	28	the	the	DET
admet-2753	23	29	molecular	molecular	ADJ
admet-2753	23	30	weight	weight	NOUN
admet-2753	23	31	cut	cut	NOUN
admet-2753	23	32	-	-	PUNCT
admet-2753	23	33	off	off	NOUN
admet-2753	23	34	(	(	PUNCT
admet-2753	23	35	mwco	mwco	NOUN
admet-2753	23	36	)	)	PUNCT
admet-2753	23	37	<	<	X
admet-2753	23	38	14	14	NUM
admet-2753	23	39	kda	kda	NOUN
admet-2753	23	40	)	)	PUNCT
admet-2753	23	41	.	.	PUNCT
admet-2753	24	1	cellulose	cellulose	NOUN
admet-2753	24	2	-	-	PUNCT
admet-2753	24	3	acetate	acetate	NOUN
admet-2753	24	4	-	-	PUNCT
admet-2753	24	5	based	base	VERB
admet-2753	24	6	size	size	NOUN
admet-2753	24	7	-	-	PUNCT
admet-2753	24	8	exclusion	exclusion	NOUN
admet-2753	24	9	membranes	membrane	NOUN
admet-2753	24	10	are	be	AUX
admet-2753	24	11	used	use	VERB
admet-2753	24	12	extensively	extensively	ADV
admet-2753	24	13	in	in	ADP
admet-2753	24	14	pharmaceutical	pharmaceutical	ADJ
admet-2753	24	15	research	research	NOUN
admet-2753	24	16	to	to	PART
admet-2753	24	17	characterize	characterize	VERB
admet-2753	24	18	drug	drug	NOUN
admet-2753	24	19	-	-	PUNCT
admet-2753	24	20	release	release	NOUN
admet-2753	24	21	kinetics	kinetic	NOUN
admet-2753	24	22	from	from	ADP
admet-2753	24	23	micro	micro	ADJ
admet-2753	24	24	-	-	ADJ
admet-2753	24	25	disperse	disperse	ADJ
admet-2753	24	26	systems	system	NOUN
admet-2753	24	27	[	[	X
admet-2753	24	28	16	16	NUM
admet-2753	24	29	]	]	PUNCT
admet-2753	24	30	and	and	CCONJ
admet-2753	24	31	measure	measure	VERB
admet-2753	24	32	the	the	DET
admet-2753	24	33	particle	particle	NOUN
admet-2753	24	34	size	size	NOUN
admet-2753	24	35	of	of	ADP
admet-2753	24	36	aggregates	aggregate	NOUN
admet-2753	24	37	,	,	PUNCT
admet-2753	24	38	micelles	micelle	NOUN
admet-2753	24	39	,	,	PUNCT
admet-2753	24	40	or	or	CCONJ
admet-2753	24	41	complexes	complexe	VERB
admet-2753	24	42	[	[	X
admet-2753	24	43	17	17	NUM
admet-2753	24	44	]	]	PUNCT
admet-2753	24	45	.	.	PUNCT
admet-2753	25	1	furthermore	furthermore	ADV
admet-2753	25	2	,	,	PUNCT
admet-2753	25	3	these	these	DET
admet-2753	25	4	membranes	membrane	NOUN
admet-2753	25	5	model	model	VERB
admet-2753	25	6	the	the	DET
admet-2753	25	7	absorption	absorption	NOUN
admet-2753	25	8	of	of	ADP
admet-2753	25	9	digested	digested	ADJ
admet-2753	25	10	food	food	NOUN
admet-2753	25	11	in	in	ADP
admet-2753	25	12	the	the	DET
admet-2753	25	13	intestines	intestine	NOUN
admet-2753	25	14	,	,	PUNCT
admet-2753	25	15	excluding	exclude	VERB
admet-2753	25	16	macromolecules	macromolecule	NOUN
admet-2753	25	17	and	and	CCONJ
admet-2753	25	18	allowing	allow	VERB
admet-2753	25	19	only	only	ADJ
admet-2753	25	20	small	small	ADJ
admet-2753	25	21	digestive	digestive	ADJ
admet-2753	25	22	products	product	NOUN
admet-2753	25	23	to	to	PART
admet-2753	25	24	permeate	permeate	VERB
admet-2753	25	25	[	[	X
admet-2753	25	26	18	18	NUM
admet-2753	25	27	]	]	PUNCT
admet-2753	25	28	.	.	PUNCT
admet-2753	26	1	recent	recent	ADJ
admet-2753	26	2	applications	application	NOUN
admet-2753	26	3	include	include	VERB
admet-2753	26	4	the	the	DET
admet-2753	26	5	characterization	characterization	NOUN
admet-2753	26	6	of	of	ADP
admet-2753	26	7	highly	highly	ADV
admet-2753	26	8	supersaturated	supersaturated	ADJ
admet-2753	26	9	solutions	solution	NOUN
admet-2753	26	10	containing	contain	VERB
admet-2753	26	11	lipophilic	lipophilic	ADJ
admet-2753	26	12	drugs	drug	NOUN
admet-2753	26	13	,	,	PUNCT
admet-2753	26	14	demonstrating	demonstrate	VERB
admet-2753	26	15	the	the	DET
admet-2753	26	16	reservoir	reservoir	NOUN
admet-2753	26	17	effect	effect	NOUN
admet-2753	26	18	of	of	ADP
admet-2753	26	19	the	the	DET
admet-2753	26	20	drug	drug	NOUN
admet-2753	26	21	-	-	PUNCT
admet-2753	26	22	rich	rich	ADJ
admet-2753	26	23	nanodroplets	nanodroplet	NOUN
admet-2753	26	24	formed	form	VERB
admet-2753	26	25	following	follow	VERB
admet-2753	26	26	liquid	liquid	ADJ
admet-2753	26	27	-	-	PUNCT
admet-2753	26	28	liquid	liquid	NOUN
admet-2753	26	29	phase	phase	NOUN
admet-2753	26	30	separation	separation	NOUN
admet-2753	26	31	(	(	PUNCT
admet-2753	26	32	llps	llps	PROPN
admet-2753	26	33	)	)	PUNCT
admet-2753	27	1	[	[	X
admet-2753	27	2	19,20	19,20	X
admet-2753	27	3	]	]	PUNCT
admet-2753	27	4	.	.	PUNCT
admet-2753	28	1	there	there	PRON
admet-2753	28	2	is	be	VERB
admet-2753	28	3	a	a	DET
admet-2753	28	4	growing	grow	VERB
admet-2753	28	5	interest	interest	NOUN
admet-2753	28	6	in	in	ADP
admet-2753	28	7	evaluating	evaluate	VERB
admet-2753	28	8	the	the	DET
admet-2753	28	9	applicability	applicability	NOUN
admet-2753	28	10	of	of	ADP
admet-2753	28	11	size	size	NOUN
admet-2753	28	12	-	-	PUNCT
admet-2753	28	13	exclusion	exclusion	NOUN
admet-2753	28	14	membranes	membrane	NOUN
admet-2753	28	15	for	for	ADP
admet-2753	28	16	assessing	assess	VERB
admet-2753	28	17	the	the	DET
admet-2753	28	18	intestinal	intestinal	ADJ
admet-2753	28	19	permeation	permeation	NOUN
admet-2753	28	20	potential	potential	NOUN
admet-2753	28	21	of	of	ADP
admet-2753	28	22	different	different	ADJ
admet-2753	28	23	formulations	formulation	NOUN
admet-2753	28	24	of	of	ADP
admet-2753	28	25	the	the	DET
admet-2753	28	26	same	same	ADJ
admet-2753	28	27	api	api	NOUN
admet-2753	28	28	;	;	PUNCT
admet-2753	28	29	therefore	therefore	ADV
admet-2753	28	30	,	,	PUNCT
admet-2753	28	31	these	these	DET
admet-2753	28	32	membranes	membrane	NOUN
admet-2753	28	33	are	be	AUX
admet-2753	28	34	also	also	ADV
admet-2753	28	35	integrated	integrate	VERB
admet-2753	28	36	into	into	ADP
admet-2753	28	37	various	various	ADJ
admet-2753	28	38	side	side	NOUN
admet-2753	28	39	-	-	PUNCT
admet-2753	28	40	by	by	ADP
admet-2753	28	41	-	-	PUNCT
admet-2753	28	42	side	side	NOUN
admet-2753	28	43	diffusion	diffusion	NOUN
admet-2753	28	44	cell	cell	NOUN
admet-2753	28	45	setups	setup	NOUN
admet-2753	28	46	[	[	X
admet-2753	28	47	2,3,21	2,3,21	NUM
admet-2753	28	48	-	-	SYM
admet-2753	28	49	24	24	NUM
admet-2753	28	50	]	]	PUNCT
admet-2753	28	51	.	.	PUNCT
admet-2753	29	1	size	size	NOUN
admet-2753	29	2	-	-	PUNCT
admet-2753	29	3	exclusion	exclusion	NOUN
admet-2753	29	4	membranes	membrane	NOUN
admet-2753	29	5	are	be	AUX
admet-2753	29	6	pre	pre	ADJ
admet-2753	29	7	-	-	ADJ
admet-2753	29	8	soaked	soaked	ADJ
admet-2753	29	9	in	in	ADP
admet-2753	29	10	aqueous	aqueous	ADJ
admet-2753	29	11	media	medium	NOUN
admet-2753	29	12	to	to	PART
admet-2753	29	13	fill	fill	VERB
admet-2753	29	14	the	the	DET
admet-2753	29	15	pores	pore	NOUN
admet-2753	29	16	.	.	PUNCT
admet-2753	30	1	the	the	DET
admet-2753	30	2	transport	transport	NOUN
admet-2753	30	3	of	of	ADP
admet-2753	30	4	neutral	neutral	ADJ
admet-2753	30	5	and	and	CCONJ
admet-2753	30	6	ionized	ionized	ADJ
admet-2753	30	7	molecules	molecule	NOUN
admet-2753	30	8	occurs	occur	VERB
admet-2753	30	9	through	through	ADP
admet-2753	30	10	diffusion	diffusion	NOUN
admet-2753	30	11	in	in	ADP
admet-2753	30	12	the	the	DET
admet-2753	30	13	water	water	NOUN
admet-2753	30	14	-	-	PUNCT
admet-2753	30	15	filled	fill	VERB
admet-2753	30	16	pores	pore	NOUN
admet-2753	30	17	unless	unless	SCONJ
admet-2753	30	18	their	their	PRON
admet-2753	30	19	hydrodynamic	hydrodynamic	ADJ
admet-2753	30	20	size	size	NOUN
admet-2753	30	21	limits	limit	VERB
admet-2753	30	22	their	their	PRON
admet-2753	30	23	transport	transport	NOUN
admet-2753	30	24	.	.	PUNCT
admet-2753	31	1	consequently	consequently	ADV
admet-2753	31	2	,	,	PUNCT
admet-2753	31	3	other	other	ADJ
admet-2753	31	4	structures	structure	NOUN
admet-2753	31	5	present	present	ADJ
admet-2753	31	6	in	in	ADP
admet-2753	31	7	the	the	DET
admet-2753	31	8	dissolution	dissolution	NOUN
admet-2753	31	9	media	medium	NOUN
admet-2753	31	10	,	,	PUNCT
admet-2753	31	11	i.e.	i.e.	X
admet-2753	31	12	,	,	PUNCT
admet-2753	31	13	surfactants	surfactant	NOUN
admet-2753	31	14	and	and	CCONJ
admet-2753	31	15	cyclodextrins	cyclodextrin	NOUN
admet-2753	31	16	(	(	PUNCT
admet-2753	31	17	cds	cds	PROPN
admet-2753	31	18	)	)	PUNCT
admet-2753	31	19	,	,	PUNCT
admet-2753	31	20	may	may	AUX
admet-2753	31	21	also	also	ADV
admet-2753	31	22	reach	reach	VERB
admet-2753	31	23	the	the	DET
admet-2753	31	24	acceptor	acceptor	NOUN
admet-2753	31	25	side	side	NOUN
admet-2753	31	26	[	[	X
admet-2753	31	27	24	24	NUM
admet-2753	31	28	]	]	PUNCT
admet-2753	31	29	.	.	PUNCT
admet-2753	32	1	while	while	SCONJ
admet-2753	32	2	in	in	ADP
admet-2753	32	3	the	the	DET
admet-2753	32	4	case	case	NOUN
admet-2753	32	5	of	of	ADP
admet-2753	32	6	transport	transport	NOUN
admet-2753	32	7	through	through	ADP
admet-2753	32	8	a	a	DET
admet-2753	32	9	lipophilic	lipophilic	ADJ
admet-2753	32	10	membrane	membrane	NOUN
admet-2753	32	11	,	,	PUNCT
admet-2753	32	12	there	there	PRON
admet-2753	32	13	are	be	VERB
admet-2753	32	14	two	two	NUM
admet-2753	32	15	aqueous	aqueous	ADJ
admet-2753	32	16	phases	phase	NOUN
admet-2753	32	17	separated	separate	VERB
admet-2753	32	18	by	by	ADP
admet-2753	32	19	an	an	DET
admet-2753	32	20	apolar	apolar	ADJ
admet-2753	32	21	organic	organic	ADJ
admet-2753	32	22	phase	phase	NOUN
admet-2753	32	23	,	,	PUNCT
admet-2753	32	24	and	and	CCONJ
admet-2753	32	25	only	only	ADV
admet-2753	32	26	the	the	DET
admet-2753	32	27	neutral	neutral	ADJ
admet-2753	32	28	drug	drug	NOUN
admet-2753	32	29	molecules	molecule	NOUN
admet-2753	32	30	partition	partition	NOUN
admet-2753	32	31	from	from	ADP
admet-2753	32	32	the	the	DET
admet-2753	32	33	donor	donor	NOUN
admet-2753	32	34	aqueous	aqueous	ADJ
admet-2753	32	35	phase	phase	NOUN
admet-2753	32	36	into	into	ADP
admet-2753	32	37	the	the	DET
admet-2753	32	38	organic	organic	ADJ
admet-2753	32	39	phase	phase	NOUN
admet-2753	32	40	,	,	PUNCT
admet-2753	32	41	then	then	ADV
admet-2753	32	42	partition	partition	VERB
admet-2753	32	43	again	again	ADV
admet-2753	32	44	into	into	ADP
admet-2753	32	45	the	the	DET
admet-2753	32	46	acceptor	acceptor	NOUN
admet-2753	32	47	phase	phase	NOUN
admet-2753	32	48	after	after	ADP
admet-2753	32	49	diffusing	diffuse	VERB
admet-2753	32	50	through	through	ADP
admet-2753	32	51	the	the	DET
admet-2753	32	52	lipophilic	lipophilic	ADJ
admet-2753	32	53	phase	phase	NOUN
admet-2753	32	54	.	.	PUNCT
admet-2753	33	1	if	if	SCONJ
admet-2753	33	2	the	the	DET
admet-2753	33	3	transport	transport	NOUN
admet-2753	33	4	through	through	ADP
admet-2753	33	5	the	the	DET
admet-2753	33	6	aqueous	aqueous	ADJ
admet-2753	33	7	boundary	boundary	ADJ
admet-2753	33	8	layer	layer	NOUN
admet-2753	33	9	adjacent	adjacent	ADJ
admet-2753	33	10	to	to	ADP
admet-2753	33	11	the	the	DET
admet-2753	33	12	membrane	membrane	NOUN
admet-2753	33	13	towards	towards	ADP
admet-2753	33	14	the	the	DET
admet-2753	33	15	membrane	membrane	NOUN
admet-2753	33	16	surface	surface	NOUN
admet-2753	33	17	is	be	AUX
admet-2753	33	18	the	the	DET
admet-2753	33	19	rate	rate	NOUN
admet-2753	33	20	-	-	PUNCT
admet-2753	33	21	limiting	limit	VERB
admet-2753	33	22	step	step	NOUN
admet-2753	33	23	of	of	ADP
admet-2753	33	24	the	the	DET
admet-2753	33	25	transport	transport	NOUN
admet-2753	33	26	,	,	PUNCT
admet-2753	33	27	then	then	ADV
admet-2753	33	28	the	the	DET
admet-2753	33	29	term	term	NOUN
admet-2753	33	30	uwl	uwl	ADV
admet-2753	33	31	-	-	PUNCT
admet-2753	33	32	limited	limit	VERB
admet-2753	33	33	transport	transport	NOUN
admet-2753	33	34	is	be	AUX
admet-2753	33	35	used	use	VERB
admet-2753	33	36	.	.	PUNCT
admet-2753	34	1	in	in	ADP
admet-2753	34	2	uwl	uwl	ADV
admet-2753	34	3	-	-	PUNCT
admet-2753	34	4	limited	limit	VERB
admet-2753	34	5	transport	transport	NOUN
admet-2753	34	6	,	,	PUNCT
admet-2753	34	7	the	the	DET
admet-2753	34	8	effective	effective	ADJ
admet-2753	34	9	concentration	concentration	NOUN
admet-2753	34	10	gradient	gradient	NOUN
admet-2753	34	11	across	across	ADP
admet-2753	34	12	the	the	DET
admet-2753	34	13	membrane	membrane	NOUN
admet-2753	34	14	is	be	AUX
admet-2753	34	15	diminished	diminish	VERB
admet-2753	34	16	because	because	SCONJ
admet-2753	34	17	of	of	ADP
admet-2753	34	18	slow	slow	ADJ
admet-2753	34	19	diffusion	diffusion	NOUN
admet-2753	34	20	in	in	ADP
admet-2753	34	21	the	the	DET
admet-2753	34	22	unstirred	unstirred	ADJ
admet-2753	34	23	water	water	NOUN
admet-2753	34	24	layer	layer	NOUN
admet-2753	34	25	,	,	PUNCT
admet-2753	34	26	particularly	particularly	ADV
admet-2753	34	27	in	in	ADP
admet-2753	34	28	the	the	DET
admet-2753	34	29	admet	admet	PROPN
admet-2753	34	30	&	&	CCONJ
admet-2753	34	31	dmpk	dmpk	PROPN
admet-2753	34	32	13(4	13(4	NUM
admet-2753	34	33	)	)	PUNCT
admet-2753	34	34	(	(	PUNCT
admet-2753	34	35	2025	2025	NUM
admet-2753	34	36	)	)	PUNCT
admet-2753	34	37	2753	2753	NUM
admet-2753	34	38	comparison	comparison	NOUN
admet-2753	34	39	of	of	ADP
admet-2753	34	40	lipophilic	lipophilic	ADJ
admet-2753	34	41	and	and	CCONJ
admet-2753	34	42	size	size	NOUN
admet-2753	34	43	-	-	PUNCT
admet-2753	34	44	exclusion	exclusion	NOUN
admet-2753	34	45	membranes	membrane	NOUN
admet-2753	34	46	doi	doi	NOUN
admet-2753	34	47	:	:	PUNCT
admet-2753	34	48	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	34	49	3	3	NUM
admet-2753	34	50	case	case	NOUN
admet-2753	34	51	of	of	ADP
admet-2753	34	52	highly	highly	ADV
admet-2753	34	53	lipophilic	lipophilic	ADJ
admet-2753	34	54	drugs	drug	NOUN
admet-2753	34	55	.	.	PUNCT
admet-2753	35	1	in	in	ADP
admet-2753	35	2	the	the	DET
admet-2753	35	3	case	case	NOUN
admet-2753	35	4	of	of	ADP
admet-2753	35	5	size	size	NOUN
admet-2753	35	6	-	-	PUNCT
admet-2753	35	7	exclusion	exclusion	NOUN
admet-2753	35	8	membranes	membrane	NOUN
admet-2753	35	9	,	,	PUNCT
admet-2753	35	10	a	a	DET
admet-2753	35	11	different	different	ADJ
admet-2753	35	12	permeation	permeation	NOUN
admet-2753	35	13	process	process	NOUN
admet-2753	35	14	occurs	occur	VERB
admet-2753	35	15	,	,	PUNCT
admet-2753	35	16	as	as	SCONJ
admet-2753	35	17	the	the	DET
admet-2753	35	18	membrane	membrane	NOUN
admet-2753	35	19	does	do	AUX
admet-2753	35	20	not	not	PART
admet-2753	35	21	contain	contain	VERB
admet-2753	35	22	lipids	lipids	ADJ
admet-2753	35	23	.	.	PUNCT
admet-2753	36	1	the	the	DET
admet-2753	36	2	donor	donor	NOUN
admet-2753	36	3	and	and	CCONJ
admet-2753	36	4	acceptor	acceptor	NOUN
admet-2753	36	5	sides	side	NOUN
admet-2753	36	6	are	be	AUX
admet-2753	36	7	filled	fill	VERB
admet-2753	36	8	with	with	ADP
admet-2753	36	9	the	the	DET
admet-2753	36	10	same	same	ADJ
admet-2753	36	11	buffer	buffer	NOUN
admet-2753	36	12	solution	solution	NOUN
admet-2753	36	13	,	,	PUNCT
admet-2753	36	14	measuring	measure	VERB
admet-2753	36	15	transport	transport	NOUN
admet-2753	36	16	speed	speed	NOUN
admet-2753	36	17	through	through	ADP
admet-2753	36	18	an	an	DET
admet-2753	36	19	aqueous	aqueous	ADJ
admet-2753	36	20	medium	medium	NOUN
admet-2753	36	21	.	.	PUNCT
admet-2753	37	1	consequently	consequently	ADV
admet-2753	37	2	,	,	PUNCT
admet-2753	37	3	for	for	ADP
admet-2753	37	4	size	size	NOUN
admet-2753	37	5	-	-	PUNCT
admet-2753	37	6	exclusion	exclusion	NOUN
admet-2753	37	7	membranes	membrane	NOUN
admet-2753	37	8	,	,	PUNCT
admet-2753	37	9	both	both	CCONJ
admet-2753	37	10	the	the	DET
admet-2753	37	11	uwl	uwl	NOUN
admet-2753	37	12	and	and	CCONJ
admet-2753	37	13	the	the	DET
admet-2753	37	14	membrane	membrane	NOUN
admet-2753	37	15	permeation	permeation	NOUN
admet-2753	37	16	involve	involve	VERB
admet-2753	37	17	aqueous	aqueous	ADJ
admet-2753	37	18	diffusion	diffusion	NOUN
admet-2753	37	19	,	,	PUNCT
admet-2753	37	20	with	with	ADP
admet-2753	37	21	no	no	DET
admet-2753	37	22	diffusion	diffusion	NOUN
admet-2753	37	23	through	through	ADP
admet-2753	37	24	a	a	DET
admet-2753	37	25	lipophilic	lipophilic	ADJ
admet-2753	37	26	phase	phase	NOUN
admet-2753	37	27	.	.	PUNCT
admet-2753	38	1	however	however	ADV
admet-2753	38	2	,	,	PUNCT
admet-2753	38	3	these	these	DET
admet-2753	38	4	two	two	NUM
admet-2753	38	5	aqueous	aqueous	ADJ
admet-2753	38	6	environments	environment	NOUN
admet-2753	38	7	may	may	AUX
admet-2753	38	8	differ	differ	VERB
admet-2753	38	9	significantly	significantly	ADV
admet-2753	38	10	due	due	ADP
admet-2753	38	11	to	to	ADP
admet-2753	38	12	the	the	DET
admet-2753	38	13	drug	drug	NOUN
admet-2753	38	14	's	's	PART
admet-2753	38	15	molecular	molecular	ADJ
admet-2753	38	16	hydration	hydration	NOUN
admet-2753	38	17	and	and	CCONJ
admet-2753	38	18	potential	potential	ADJ
admet-2753	38	19	interaction	interaction	NOUN
admet-2753	38	20	with	with	ADP
admet-2753	38	21	the	the	DET
admet-2753	38	22	filter	filter	NOUN
admet-2753	38	23	material	material	NOUN
admet-2753	38	24	.	.	PUNCT
admet-2753	39	1	in	in	ADP
admet-2753	39	2	the	the	DET
admet-2753	39	3	case	case	NOUN
admet-2753	39	4	of	of	ADP
admet-2753	39	5	the	the	DET
admet-2753	39	6	size	size	NOUN
admet-2753	39	7	-	-	PUNCT
admet-2753	39	8	exclusion	exclusion	NOUN
admet-2753	39	9	membrane	membrane	NOUN
admet-2753	39	10	,	,	PUNCT
admet-2753	39	11	in	in	ADP
admet-2753	39	12	addition	addition	NOUN
admet-2753	39	13	to	to	ADP
admet-2753	39	14	the	the	DET
admet-2753	39	15	presence	presence	NOUN
admet-2753	39	16	of	of	ADP
admet-2753	39	17	uwl	uwl	X
admet-2753	39	18	[	[	X
admet-2753	39	19	25	25	NUM
admet-2753	39	20	]	]	PUNCT
admet-2753	39	21	,	,	PUNCT
admet-2753	39	22	it	it	PRON
admet-2753	39	23	is	be	AUX
admet-2753	39	24	also	also	ADV
admet-2753	39	25	necessary	necessary	ADJ
admet-2753	39	26	to	to	PART
admet-2753	39	27	distinguish	distinguish	VERB
admet-2753	39	28	between	between	ADP
admet-2753	39	29	the	the	DET
admet-2753	39	30	two	two	NUM
admet-2753	39	31	cases	case	NOUN
admet-2753	39	32	when	when	SCONJ
admet-2753	39	33	the	the	DET
admet-2753	39	34	excipient	excipient	NOUN
admet-2753	39	35	passes	pass	VERB
admet-2753	39	36	through	through	ADP
admet-2753	39	37	the	the	DET
admet-2753	39	38	membrane	membrane	NOUN
admet-2753	39	39	and	and	CCONJ
admet-2753	39	40	when	when	SCONJ
admet-2753	39	41	it	it	PRON
admet-2753	39	42	does	do	VERB
admet-2753	39	43	not	not	PART
admet-2753	39	44	.	.	PUNCT
admet-2753	40	1	dissolution	dissolution	NOUN
admet-2753	40	2	-	-	PUNCT
admet-2753	40	3	permeation	permeation	NOUN
admet-2753	40	4	setups	setup	NOUN
admet-2753	40	5	may	may	AUX
admet-2753	40	6	contain	contain	VERB
admet-2753	40	7	many	many	ADJ
admet-2753	40	8	different	different	ADJ
admet-2753	40	9	artificial	artificial	ADJ
admet-2753	40	10	membranes	membrane	NOUN
admet-2753	40	11	.	.	PUNCT
admet-2753	41	1	in	in	ADP
admet-2753	41	2	general	general	ADJ
admet-2753	41	3	,	,	PUNCT
admet-2753	41	4	they	they	PRON
admet-2753	41	5	demonstrate	demonstrate	VERB
admet-2753	41	6	better	well	ADJ
admet-2753	41	7	discrimination	discrimination	NOUN
admet-2753	41	8	of	of	ADP
admet-2753	41	9	formulations	formulation	NOUN
admet-2753	41	10	compared	compare	VERB
admet-2753	41	11	to	to	ADP
admet-2753	41	12	simple	simple	ADJ
admet-2753	41	13	dissolution	dissolution	NOUN
admet-2753	41	14	setups	setup	NOUN
admet-2753	41	15	,	,	PUNCT
admet-2753	41	16	enabling	enable	VERB
admet-2753	41	17	the	the	DET
admet-2753	41	18	study	study	NOUN
admet-2753	41	19	of	of	ADP
admet-2753	41	20	the	the	DET
admet-2753	41	21	effects	effect	NOUN
admet-2753	41	22	of	of	ADP
admet-2753	41	23	formulation	formulation	NOUN
admet-2753	41	24	additives	additive	NOUN
admet-2753	41	25	on	on	ADP
admet-2753	41	26	dissolution	dissolution	NOUN
admet-2753	41	27	and	and	CCONJ
admet-2753	41	28	membrane	membrane	NOUN
admet-2753	41	29	transport	transport	NOUN
admet-2753	41	30	.	.	PUNCT
admet-2753	42	1	solubilizing	solubilize	VERB
admet-2753	42	2	additives	additive	NOUN
admet-2753	42	3	,	,	PUNCT
admet-2753	42	4	such	such	ADJ
admet-2753	42	5	as	as	ADP
admet-2753	42	6	surfactants	surfactant	NOUN
admet-2753	42	7	and	and	CCONJ
admet-2753	42	8	complexing	complexe	VERB
admet-2753	42	9	agents	agent	NOUN
admet-2753	42	10	(	(	PUNCT
admet-2753	42	11	cds	cds	PROPN
admet-2753	42	12	)	)	PUNCT
admet-2753	42	13	,	,	PUNCT
admet-2753	42	14	generally	generally	ADV
admet-2753	42	15	enhance	enhance	VERB
admet-2753	42	16	the	the	DET
admet-2753	42	17	solubility	solubility	NOUN
admet-2753	42	18	of	of	ADP
admet-2753	42	19	the	the	DET
admet-2753	42	20	apis	apis	NOUN
admet-2753	42	21	while	while	SCONJ
admet-2753	42	22	reducing	reduce	VERB
admet-2753	42	23	free	free	ADJ
admet-2753	42	24	drug	drug	NOUN
admet-2753	42	25	concentration	concentration	NOUN
admet-2753	42	26	,	,	PUNCT
admet-2753	42	27	decreasing	decrease	VERB
admet-2753	42	28	the	the	DET
admet-2753	42	29	flux	flux	NOUN
admet-2753	42	30	across	across	ADP
admet-2753	42	31	the	the	DET
admet-2753	42	32	membrane	membrane	NOUN
admet-2753	42	33	[	[	X
admet-2753	42	34	26	26	NUM
admet-2753	42	35	]	]	PUNCT
admet-2753	42	36	.	.	PUNCT
admet-2753	43	1	moreover	moreover	ADV
admet-2753	43	2	,	,	PUNCT
admet-2753	43	3	the	the	DET
admet-2753	43	4	decrease	decrease	NOUN
admet-2753	43	5	in	in	ADP
admet-2753	43	6	the	the	DET
admet-2753	43	7	apparent	apparent	ADJ
admet-2753	43	8	permeability	permeability	NOUN
admet-2753	43	9	was	be	AUX
admet-2753	43	10	found	find	VERB
admet-2753	43	11	to	to	PART
admet-2753	43	12	be	be	AUX
admet-2753	43	13	proportional	proportional	ADJ
admet-2753	43	14	to	to	ADP
admet-2753	43	15	the	the	DET
admet-2753	43	16	solubility	solubility	NOUN
admet-2753	43	17	enhancement	enhancement	NOUN
admet-2753	43	18	achieved	achieve	VERB
admet-2753	43	19	by	by	ADP
admet-2753	43	20	the	the	DET
admet-2753	43	21	complexing	complexe	VERB
admet-2753	43	22	agent	agent	NOUN
admet-2753	43	23	[	[	X
admet-2753	43	24	27,28	27,28	NUM
admet-2753	43	25	]	]	X
admet-2753	43	26	.	.	PUNCT
admet-2753	44	1	this	this	DET
admet-2753	44	2	interplay	interplay	NOUN
admet-2753	44	3	between	between	ADP
admet-2753	44	4	solubility	solubility	NOUN
admet-2753	44	5	and	and	CCONJ
admet-2753	44	6	permeability	permeability	NOUN
admet-2753	44	7	was	be	AUX
admet-2753	44	8	first	first	ADV
admet-2753	44	9	demonstrated	demonstrate	VERB
admet-2753	44	10	in	in	ADP
admet-2753	44	11	the	the	DET
admet-2753	44	12	rat	rat	NOUN
admet-2753	44	13	perfusion	perfusion	NOUN
admet-2753	44	14	model	model	NOUN
admet-2753	44	15	and	and	CCONJ
admet-2753	44	16	parallel	parallel	ADJ
admet-2753	44	17	artificial	artificial	ADJ
admet-2753	44	18	membrane	membrane	NOUN
admet-2753	44	19	permeability	permeability	NOUN
admet-2753	44	20	assay	assay	VERB
admet-2753	45	1	[	[	X
admet-2753	45	2	11	11	NUM
admet-2753	45	3	]	]	PUNCT
admet-2753	45	4	(	(	PUNCT
admet-2753	45	5	pampa	pampa	NOUN
admet-2753	45	6	)	)	PUNCT
admet-2753	45	7	membranes	membrane	NOUN
admet-2753	45	8	[	[	X
admet-2753	45	9	29	29	NUM
admet-2753	45	10	]	]	PUNCT
admet-2753	45	11	.	.	PUNCT
admet-2753	46	1	later	later	ADV
admet-2753	46	2	,	,	PUNCT
admet-2753	46	3	it	it	PRON
admet-2753	46	4	was	be	AUX
admet-2753	46	5	shown	show	VERB
admet-2753	46	6	that	that	SCONJ
admet-2753	46	7	a	a	DET
admet-2753	46	8	similar	similar	ADJ
admet-2753	46	9	phenomenon	phenomenon	NOUN
admet-2753	46	10	can	can	AUX
admet-2753	46	11	be	be	AUX
admet-2753	46	12	captured	capture	VERB
admet-2753	46	13	using	use	VERB
admet-2753	46	14	cellulose	cellulose	NOUN
admet-2753	46	15	membranes	membrane	NOUN
admet-2753	46	16	[	[	X
admet-2753	46	17	19,22,23,30,31	19,22,23,30,31	X
admet-2753	46	18	]	]	X
admet-2753	46	19	when	when	SCONJ
admet-2753	46	20	only	only	ADV
admet-2753	46	21	the	the	DET
admet-2753	46	22	free	free	ADJ
admet-2753	46	23	drug	drug	NOUN
admet-2753	46	24	can	can	AUX
admet-2753	46	25	cross	cross	VERB
admet-2753	46	26	the	the	DET
admet-2753	46	27	size	size	NOUN
admet-2753	46	28	-	-	PUNCT
admet-2753	46	29	exclusion	exclusion	NOUN
admet-2753	46	30	membrane	membrane	NOUN
admet-2753	46	31	;	;	PUNCT
admet-2753	46	32	however	however	ADV
admet-2753	46	33	,	,	PUNCT
admet-2753	46	34	most	most	ADJ
admet-2753	46	35	of	of	ADP
admet-2753	46	36	these	these	DET
admet-2753	46	37	membranes	membrane	NOUN
admet-2753	46	38	can	can	AUX
admet-2753	46	39	not	not	PART
admet-2753	46	40	distinguish	distinguish	VERB
admet-2753	46	41	the	the	DET
admet-2753	46	42	ionized	ionized	ADJ
admet-2753	46	43	and	and	CCONJ
admet-2753	46	44	the	the	DET
admet-2753	46	45	neutral	neutral	ADJ
admet-2753	46	46	form	form	NOUN
admet-2753	46	47	of	of	ADP
admet-2753	46	48	the	the	DET
admet-2753	46	49	drug	drug	NOUN
admet-2753	46	50	.	.	PUNCT
admet-2753	47	1	studies	study	NOUN
admet-2753	47	2	were	be	AUX
admet-2753	47	3	also	also	ADV
admet-2753	47	4	conducted	conduct	VERB
admet-2753	47	5	to	to	PART
admet-2753	47	6	evaluate	evaluate	VERB
admet-2753	47	7	how	how	SCONJ
admet-2753	47	8	the	the	DET
admet-2753	47	9	composition	composition	NOUN
admet-2753	47	10	and	and	CCONJ
admet-2753	47	11	type	type	NOUN
admet-2753	47	12	of	of	ADP
admet-2753	47	13	polymer	polymer	NOUN
admet-2753	47	14	can	can	AUX
admet-2753	47	15	affect	affect	VERB
admet-2753	47	16	the	the	DET
admet-2753	47	17	dissolution	dissolution	NOUN
admet-2753	47	18	and	and	CCONJ
admet-2753	47	19	permeation	permeation	NOUN
admet-2753	47	20	of	of	ADP
admet-2753	47	21	amorphous	amorphous	ADJ
admet-2753	47	22	solid	solid	ADJ
admet-2753	47	23	dispersions	dispersion	NOUN
admet-2753	47	24	implementing	implement	VERB
admet-2753	47	25	size	size	NOUN
admet-2753	47	26	-	-	PUNCT
admet-2753	47	27	exclusion	exclusion	NOUN
admet-2753	47	28	membranes	membrane	NOUN
admet-2753	47	29	[	[	X
admet-2753	47	30	19,22,32	19,22,32	NUM
admet-2753	47	31	]	]	PUNCT
admet-2753	47	32	.	.	PUNCT
admet-2753	48	1	in	in	ADP
admet-2753	48	2	conclusion	conclusion	NOUN
admet-2753	48	3	,	,	PUNCT
admet-2753	48	4	the	the	DET
admet-2753	48	5	use	use	NOUN
admet-2753	48	6	of	of	ADP
admet-2753	48	7	cellulose	cellulose	NOUN
admet-2753	48	8	-	-	PUNCT
admet-2753	48	9	based	base	VERB
admet-2753	48	10	membranes	membrane	NOUN
admet-2753	48	11	as	as	ADP
admet-2753	48	12	a	a	DET
admet-2753	48	13	simple	simple	ADJ
admet-2753	48	14	surrogate	surrogate	NOUN
admet-2753	48	15	for	for	ADP
admet-2753	48	16	caco-2	caco-2	NUM
admet-2753	48	17	or	or	CCONJ
admet-2753	48	18	pampa	pampa	NOUN
admet-2753	48	19	membranes	membrane	NOUN
admet-2753	48	20	in	in	ADP
admet-2753	48	21	dissolution	dissolution	NOUN
admet-2753	48	22	-	-	PUNCT
admet-2753	48	23	permeation	permeation	NOUN
admet-2753	48	24	assays	assay	NOUN
admet-2753	48	25	of	of	ADP
admet-2753	48	26	drug	drug	NOUN
admet-2753	48	27	formulations	formulation	NOUN
admet-2753	48	28	presenting	present	VERB
admet-2753	48	29	solubility	solubility	NOUN
admet-2753	48	30	-	-	PUNCT
admet-2753	48	31	permeability	permeability	NOUN
admet-2753	48	32	interplay	interplay	NOUN
admet-2753	48	33	has	have	AUX
admet-2753	48	34	already	already	ADV
admet-2753	48	35	been	be	AUX
admet-2753	48	36	published	publish	VERB
admet-2753	48	37	several	several	ADJ
admet-2753	48	38	times	time	NOUN
admet-2753	48	39	in	in	ADP
admet-2753	48	40	the	the	DET
admet-2753	48	41	literature	literature	NOUN
admet-2753	48	42	;	;	PUNCT
admet-2753	48	43	however	however	ADV
admet-2753	48	44	,	,	PUNCT
admet-2753	48	45	a	a	DET
admet-2753	48	46	thorough	thorough	ADJ
admet-2753	48	47	analysis	analysis	NOUN
admet-2753	48	48	is	be	AUX
admet-2753	48	49	needed	need	VERB
admet-2753	48	50	to	to	PART
admet-2753	48	51	understand	understand	VERB
admet-2753	48	52	the	the	DET
admet-2753	48	53	underlying	underlying	ADJ
admet-2753	48	54	mechanism	mechanism	NOUN
admet-2753	48	55	and	and	CCONJ
admet-2753	48	56	uncover	uncover	VERB
admet-2753	48	57	the	the	DET
admet-2753	48	58	limitations	limitation	NOUN
admet-2753	48	59	of	of	ADP
admet-2753	48	60	such	such	ADJ
admet-2753	48	61	application	application	NOUN
admet-2753	48	62	.	.	PUNCT
admet-2753	49	1	for	for	ADP
admet-2753	49	2	that	that	DET
admet-2753	49	3	reason	reason	NOUN
admet-2753	49	4	,	,	PUNCT
admet-2753	49	5	this	this	DET
admet-2753	49	6	study	study	NOUN
admet-2753	49	7	aims	aim	VERB
admet-2753	49	8	to	to	PART
admet-2753	49	9	investigate	investigate	VERB
admet-2753	49	10	whether	whether	SCONJ
admet-2753	49	11	size	size	NOUN
admet-2753	49	12	-	-	PUNCT
admet-2753	49	13	exclusion	exclusion	NOUN
admet-2753	49	14	membranes	membrane	NOUN
admet-2753	49	15	can	can	AUX
admet-2753	49	16	be	be	AUX
admet-2753	49	17	an	an	DET
admet-2753	49	18	alternative	alternative	NOUN
admet-2753	49	19	for	for	ADP
admet-2753	49	20	lipophilic	lipophilic	ADJ
admet-2753	49	21	membranes	membrane	NOUN
admet-2753	49	22	in	in	ADP
admet-2753	49	23	the	the	DET
admet-2753	49	24	case	case	NOUN
admet-2753	49	25	of	of	ADP
admet-2753	49	26	studying	study	VERB
admet-2753	49	27	drug	drug	NOUN
admet-2753	49	28	formulations	formulation	NOUN
admet-2753	49	29	of	of	ADP
admet-2753	49	30	the	the	DET
admet-2753	49	31	same	same	ADJ
admet-2753	49	32	api	api	NOUN
admet-2753	49	33	and	and	CCONJ
admet-2753	49	34	what	what	PRON
admet-2753	49	35	the	the	DET
admet-2753	49	36	advantages	advantage	NOUN
admet-2753	49	37	and	and	CCONJ
admet-2753	49	38	limitations	limitation	NOUN
admet-2753	49	39	are	be	AUX
admet-2753	49	40	.	.	PUNCT
admet-2753	50	1	therefore	therefore	ADV
admet-2753	50	2	,	,	PUNCT
admet-2753	50	3	this	this	DET
admet-2753	50	4	paper	paper	NOUN
admet-2753	50	5	aims	aim	VERB
admet-2753	50	6	to	to	PART
admet-2753	50	7	compare	compare	VERB
admet-2753	50	8	the	the	DET
admet-2753	50	9	simplest	simple	ADJ
admet-2753	50	10	lipophilic	lipophilic	NOUN
admet-2753	50	11	(	(	PUNCT
admet-2753	50	12	pvdf	pvdf	NOUN
admet-2753	50	13	filter	filter	NOUN
admet-2753	50	14	impregnated	impregnate	VERB
admet-2753	50	15	with	with	ADP
admet-2753	50	16	n	n	CCONJ
admet-2753	50	17	-	-	PUNCT
admet-2753	50	18	dodecane	dodecane	NOUN
admet-2753	50	19	)	)	PUNCT
admet-2753	50	20	and	and	CCONJ
admet-2753	50	21	size	size	NOUN
admet-2753	50	22	-	-	PUNCT
admet-2753	50	23	exclusion	exclusion	NOUN
admet-2753	50	24	membranes	membrane	NOUN
admet-2753	50	25	(	(	PUNCT
admet-2753	50	26	molecular	molecular	ADJ
admet-2753	50	27	weight	weight	NOUN
admet-2753	50	28	cut	cut	NOUN
admet-2753	50	29	-	-	PUNCT
admet-2753	50	30	offs	off	NOUN
admet-2753	50	31	of	of	ADP
admet-2753	50	32	1	1	NUM
admet-2753	50	33	kda	kda	NOUN
admet-2753	50	34	and	and	CCONJ
admet-2753	50	35	6	6	NUM
admet-2753	50	36	to	to	PART
admet-2753	50	37	8	8	NUM
admet-2753	50	38	kda	kda	NOUN
admet-2753	50	39	)	)	PUNCT
admet-2753	50	40	on	on	ADP
admet-2753	50	41	theoretical	theoretical	ADJ
admet-2753	50	42	grounds	ground	NOUN
admet-2753	50	43	,	,	PUNCT
admet-2753	50	44	studying	study	VERB
admet-2753	50	45	the	the	DET
admet-2753	50	46	driving	drive	VERB
admet-2753	50	47	force	force	NOUN
admet-2753	50	48	of	of	ADP
admet-2753	50	49	membrane	membrane	NOUN
admet-2753	50	50	transport	transport	NOUN
admet-2753	50	51	.	.	PUNCT
admet-2753	51	1	practical	practical	ADJ
admet-2753	51	2	aspects	aspect	NOUN
admet-2753	51	3	are	be	AUX
admet-2753	51	4	also	also	ADV
admet-2753	51	5	considered	consider	VERB
admet-2753	51	6	to	to	PART
admet-2753	51	7	see	see	VERB
admet-2753	51	8	what	what	PRON
admet-2753	51	9	assay	assay	NOUN
admet-2753	51	10	conditions	condition	NOUN
admet-2753	51	11	might	might	AUX
admet-2753	51	12	be	be	AUX
admet-2753	51	13	used	use	VERB
admet-2753	51	14	for	for	ADP
admet-2753	51	15	the	the	DET
admet-2753	51	16	membranes	membrane	NOUN
admet-2753	51	17	to	to	PART
admet-2753	51	18	see	see	VERB
admet-2753	51	19	a	a	DET
admet-2753	51	20	similar	similar	ADJ
admet-2753	51	21	effect	effect	NOUN
admet-2753	51	22	when	when	SCONJ
admet-2753	51	23	adding	add	VERB
admet-2753	51	24	a	a	DET
admet-2753	51	25	solubilizing	solubilize	VERB
admet-2753	51	26	additive	additive	NOUN
admet-2753	51	27	.	.	PUNCT
admet-2753	52	1	carvedilol	carvedilol	PROPN
admet-2753	52	2	,	,	PUNCT
admet-2753	52	3	a	a	DET
admet-2753	52	4	non	non	ADJ
admet-2753	52	5	-	-	ADJ
admet-2753	52	6	selective	selective	ADJ
admet-2753	52	7	β	β	NOUN
admet-2753	52	8	-	-	NOUN
admet-2753	52	9	receptor	receptor	NOUN
admet-2753	52	10	blocker	blocker	NOUN
admet-2753	52	11	,	,	PUNCT
admet-2753	52	12	was	be	AUX
admet-2753	52	13	chosen	choose	VERB
admet-2753	52	14	as	as	ADP
admet-2753	52	15	the	the	DET
admet-2753	52	16	model	model	NOUN
admet-2753	52	17	api	api	NOUN
admet-2753	52	18	,	,	PUNCT
admet-2753	52	19	while	while	SCONJ
admet-2753	52	20	the	the	DET
admet-2753	52	21	model	model	NOUN
admet-2753	52	22	solubilizing	solubilize	VERB
admet-2753	52	23	additive	additive	NOUN
admet-2753	52	24	with	with	ADP
admet-2753	52	25	known	know	VERB
admet-2753	52	26	size	size	NOUN
admet-2753	52	27	and	and	CCONJ
admet-2753	52	28	attributes	attribute	VERB
admet-2753	52	29	,	,	PUNCT
admet-2753	52	30	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	52	31	-	-	PUNCT
admet-2753	52	32	β	β	NOUN
admet-2753	52	33	-	-	NOUN
admet-2753	52	34	cyclodextrin	cyclodextrin	NOUN
admet-2753	52	35	(	(	PUNCT
admet-2753	52	36	hp	hp	PROPN
admet-2753	52	37	-	-	PUNCT
admet-2753	52	38	β	β	NOUN
admet-2753	52	39	-	-	NOUN
admet-2753	52	40	cd	cd	NOUN
admet-2753	52	41	)	)	PUNCT
admet-2753	52	42	,	,	PUNCT
admet-2753	52	43	was	be	AUX
admet-2753	52	44	chosen	choose	VERB
admet-2753	52	45	,	,	PUNCT
admet-2753	52	46	which	which	PRON
admet-2753	52	47	shows	show	VERB
admet-2753	52	48	the	the	DET
admet-2753	52	49	highest	high	ADJ
admet-2753	52	50	complexation	complexation	NOUN
admet-2753	52	51	efficiency	efficiency	NOUN
admet-2753	52	52	(	(	PUNCT
admet-2753	52	53	ce	ce	PROPN
admet-2753	52	54	)	)	PUNCT
admet-2753	52	55	with	with	ADP
admet-2753	52	56	car	car	NOUN
admet-2753	52	57	among	among	ADP
admet-2753	52	58	the	the	DET
admet-2753	52	59	cyclodextrins	cyclodextrin	NOUN
admet-2753	53	1	[	[	X
admet-2753	53	2	33	33	NUM
admet-2753	53	3	-	-	SYM
admet-2753	53	4	35	35	NUM
admet-2753	53	5	]	]	PUNCT
admet-2753	53	6	.	.	PUNCT
admet-2753	54	1	experimental	experimental	ADJ
admet-2753	54	2	materials	material	NOUN
admet-2753	54	3	carvedilol	carvedilol	PROPN
admet-2753	54	4	form	form	NOUN
admet-2753	54	5	ii	ii	PROPN
admet-2753	54	6	(	(	PUNCT
admet-2753	54	7	car	car	NOUN
admet-2753	54	8	,	,	PUNCT
admet-2753	54	9	a	a	DET
admet-2753	54	10	bcs	bcs	NOUN
admet-2753	54	11	class	class	PROPN
admet-2753	54	12	ii	ii	PROPN
admet-2753	54	13	,	,	PUNCT
admet-2753	54	14	poorly	poorly	ADV
admet-2753	54	15	water	water	NOUN
admet-2753	54	16	-	-	PUNCT
admet-2753	54	17	soluble	soluble	ADJ
admet-2753	54	18	but	but	CCONJ
admet-2753	54	19	well	well	ADV
admet-2753	54	20	permeable	permeable	ADJ
admet-2753	54	21	,	,	PUNCT
admet-2753	54	22	monovalent	monovalent	ADJ
admet-2753	54	23	weak	weak	ADJ
admet-2753	54	24	base	base	NOUN
admet-2753	54	25	with	with	ADP
admet-2753	54	26	a	a	DET
admet-2753	54	27	pka	pka	NOUN
admet-2753	54	28	of	of	ADP
admet-2753	54	29	7.78	7.78	NUM
admet-2753	54	30	±	±	NUM
admet-2753	54	31	0.04	0.04	NUM
admet-2753	55	1	[	[	X
admet-2753	55	2	36,37	36,37	X
admet-2753	55	3	]	]	X
admet-2753	55	4	(	(	PUNCT
admet-2753	55	5	at	at	ADP
admet-2753	55	6	37	37	NUM
admet-2753	55	7	°	°	NOUN
admet-2753	55	8	c	c	NOUN
admet-2753	55	9	,	,	PUNCT
admet-2753	55	10	i	i	NOUN
admet-2753	55	11	=	=	NOUN
admet-2753	55	12	0.15	0.15	NUM
admet-2753	55	13	)	)	PUNCT
admet-2753	55	14	,	,	PUNCT
admet-2753	55	15	406.482	406.482	NUM
admet-2753	55	16	g	g	NOUN
admet-2753	55	17	mol-1	mol-1	NOUN
admet-2753	55	18	,	,	PUNCT
admet-2753	55	19	structure	structure	NOUN
admet-2753	55	20	shown	show	VERB
admet-2753	55	21	in	in	ADP
admet-2753	55	22	figure	figure	NOUN
admet-2753	55	23	1	1	NUM
admet-2753	55	24	)	)	PUNCT
admet-2753	55	25	was	be	AUX
admet-2753	55	26	purchased	purchase	VERB
admet-2753	55	27	from	from	ADP
admet-2753	55	28	sigma	sigma	PROPN
admet-2753	55	29	-	-	PUNCT
admet-2753	55	30	aldrich	aldrich	PROPN
admet-2753	55	31	co.	co.	PROPN
admet-2753	55	32	llc	llc	PROPN
admet-2753	55	33	.	.	PUNCT
admet-2753	56	1	(	(	PUNCT
admet-2753	56	2	st	st	PROPN
admet-2753	56	3	.	.	PROPN
admet-2753	56	4	louis	louis	PROPN
admet-2753	56	5	,	,	PUNCT
admet-2753	56	6	mo	mo	PROPN
admet-2753	56	7	,	,	PUNCT
admet-2753	56	8	usa	usa	PROPN
admet-2753	56	9	)	)	PUNCT
admet-2753	56	10	.	.	PUNCT
admet-2753	57	1	from	from	ADP
admet-2753	57	2	the	the	DET
admet-2753	57	3	commercially	commercially	ADV
admet-2753	57	4	available	available	ADJ
admet-2753	57	5	form	form	PROPN
admet-2753	57	6	ii	ii	PROPN
admet-2753	57	7	,	,	PUNCT
admet-2753	57	8	the	the	DET
admet-2753	57	9	thermodynamically	thermodynamically	ADV
admet-2753	57	10	stable	stable	ADJ
admet-2753	57	11	form	form	NOUN
admet-2753	57	12	i	i	PRON
admet-2753	57	13	was	be	AUX
admet-2753	57	14	prepared	prepared	ADJ
admet-2753	57	15	in	in	ADP
admet-2753	57	16	-	-	PUNCT
admet-2753	57	17	house	house	NOUN
admet-2753	57	18	based	base	VERB
admet-2753	57	19	on	on	ADP
admet-2753	57	20	patents	patent	NOUN
admet-2753	57	21	and	and	CCONJ
admet-2753	57	22	literature	literature	NOUN
admet-2753	57	23	data	datum	NOUN
admet-2753	57	24	[	[	X
admet-2753	57	25	38,39	38,39	NOUN
admet-2753	57	26	]	]	X
admet-2753	57	27	(	(	PUNCT
admet-2753	57	28	main	main	ADJ
admet-2753	57	29	parameters	parameter	NOUN
admet-2753	57	30	:	:	PUNCT
admet-2753	57	31	form	form	PROPN
admet-2753	57	32	ii	ii	PROPN
admet-2753	57	33	suspended	suspend	VERB
admet-2753	57	34	in	in	ADP
admet-2753	57	35	ethyl	ethyl	PROPN
admet-2753	57	36	acetate	acetate	NOUN
admet-2753	57	37	at	at	ADP
admet-2753	57	38	50	50	NUM
admet-2753	57	39	°	°	NOUN
admet-2753	57	40	c	c	NOUN
admet-2753	57	41	,	,	PUNCT
admet-2753	57	42	crystal	crystal	NOUN
admet-2753	57	43	seeding	seeding	NOUN
admet-2753	57	44	and	and	CCONJ
admet-2753	57	45	stirring	stir	VERB
admet-2753	57	46	for	for	ADP
admet-2753	57	47	3	3	NUM
admet-2753	57	48	h	h	NOUN
admet-2753	57	49	,	,	PUNCT
admet-2753	57	50	cooling	cool	VERB
admet-2753	57	51	for	for	ADP
admet-2753	57	52	room	room	NOUN
admet-2753	57	53	temperature	temperature	NOUN
admet-2753	57	54	)	)	PUNCT
admet-2753	57	55	and	and	CCONJ
admet-2753	57	56	was	be	AUX
admet-2753	57	57	verified	verify	VERB
admet-2753	57	58	by	by	ADP
admet-2753	57	59	x	x	NOUN
admet-2753	57	60	-	-	NOUN
admet-2753	57	61	ray	ray	NOUN
admet-2753	57	62	powder	powder	NOUN
admet-2753	57	63	diffraction	diffraction	NOUN
admet-2753	57	64	(	(	PUNCT
admet-2753	57	65	xrpd	xrpd	ADJ
admet-2753	57	66	)	)	PUNCT
admet-2753	57	67	and	and	CCONJ
admet-2753	57	68	raman	raman	NOUN
admet-2753	57	69	-	-	PUNCT
admet-2753	57	70	spectroscopy	spectroscopy	NOUN
admet-2753	57	71	.	.	PUNCT
admet-2753	58	1	hp	hp	PROPN
admet-2753	58	2	-	-	PUNCT
admet-2753	58	3	β	β	NOUN
admet-2753	58	4	-	-	NOUN
admet-2753	58	5	cd	cd	PROPN
admet-2753	58	6	,	,	PUNCT
admet-2753	58	7	a	a	DET
admet-2753	58	8	doughnut	doughnut	NOUN
admet-2753	58	9	-	-	PUNCT
admet-2753	58	10	shaped	shape	VERB
admet-2753	58	11	molecule	molecule	NOUN
admet-2753	58	12	consisting	consist	VERB
admet-2753	58	13	of	of	ADP
admet-2753	58	14	seven	seven	NUM
admet-2753	58	15	alpha	alpha	NOUN
admet-2753	58	16	-	-	PUNCT
admet-2753	58	17	d	d	NOUN
admet-2753	58	18	-	-	PUNCT
admet-2753	58	19	glucopyranose	glucopyranose	NOUN
admet-2753	58	20	units	unit	NOUN
admet-2753	58	21	with	with	ADP
admet-2753	58	22	an	an	DET
admet-2753	58	23	internal	internal	ADJ
admet-2753	58	24	cavity	cavity	NOUN
admet-2753	58	25	known	know	VERB
admet-2753	58	26	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	58	27	p.	p.	PROPN
admet-2753	58	28	tőzsér	tőzsér	PROPN
admet-2753	58	29	et	et	PROPN
admet-2753	58	30	al	al	PROPN
admet-2753	58	31	.	.	PROPN
admet-2753	58	32	admet	admet	PROPN
admet-2753	58	33	&	&	CCONJ
admet-2753	58	34	dmpk	dmpk	PROPN
admet-2753	58	35	13(4	13(4	NUM
admet-2753	58	36	)	)	PUNCT
admet-2753	58	37	(	(	PUNCT
admet-2753	58	38	2025	2025	NUM
admet-2753	58	39	)	)	PUNCT
admet-2753	58	40	2753	2753	NUM
admet-2753	58	41	4	4	NUM
admet-2753	58	42	as	as	ADP
admet-2753	58	43	a	a	DET
admet-2753	58	44	solubilizing	solubilize	VERB
admet-2753	58	45	agent	agent	NOUN
admet-2753	58	46	(	(	PUNCT
admet-2753	58	47	ds	ds	ADJ
admet-2753	58	48	:	:	PUNCT
admet-2753	58	49	4.34	4.34	NUM
admet-2753	58	50	,	,	PUNCT
admet-2753	58	51	average	average	ADJ
admet-2753	58	52	molecular	molecular	ADJ
admet-2753	58	53	weight	weight	NOUN
admet-2753	58	54	1391	1391	NUM
admet-2753	58	55	g	g	NOUN
admet-2753	58	56	mol-1	mol-1	NOUN
admet-2753	58	57	,	,	PUNCT
admet-2753	58	58	structure	structure	NOUN
admet-2753	58	59	shown	show	VERB
admet-2753	58	60	in	in	ADP
admet-2753	58	61	figure	figure	NOUN
admet-2753	58	62	1	1	NUM
admet-2753	58	63	)	)	PUNCT
admet-2753	58	64	,	,	PUNCT
admet-2753	58	65	was	be	AUX
admet-2753	58	66	obtained	obtain	VERB
admet-2753	58	67	from	from	ADP
admet-2753	58	68	janssen	janssen	PROPN
admet-2753	58	69	(	(	PUNCT
admet-2753	58	70	beerse	beerse	ADJ
admet-2753	58	71	,	,	PUNCT
admet-2753	58	72	belgium	belgium	NOUN
admet-2753	58	73	)	)	PUNCT
admet-2753	58	74	.	.	PUNCT
admet-2753	59	1	figure	figure	NOUN
admet-2753	59	2	1	1	NUM
admet-2753	59	3	.	.	PUNCT
admet-2753	60	1	the	the	DET
admet-2753	60	2	structural	structural	ADJ
admet-2753	60	3	formula	formula	NOUN
admet-2753	60	4	of	of	ADP
admet-2753	60	5	car	car	NOUN
admet-2753	60	6	[	[	X
admet-2753	60	7	40	40	NUM
admet-2753	60	8	]	]	PUNCT
admet-2753	60	9	and	and	CCONJ
admet-2753	60	10	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	60	11	-	-	PUNCT
admet-2753	60	12	beta	beta	NOUN
admet-2753	60	13	-	-	PUNCT
admet-2753	60	14	cyclodextrin	cyclodextrin	NOUN
admet-2753	60	15	[	[	X
admet-2753	60	16	41	41	NUM
admet-2753	60	17	]	]	X
admet-2753	60	18	methanol	methanol	NOUN
admet-2753	60	19	was	be	AUX
admet-2753	60	20	purchased	purchase	VERB
admet-2753	60	21	from	from	ADP
admet-2753	60	22	thomasker	thomasker	NOUN
admet-2753	60	23	(	(	PUNCT
admet-2753	60	24	budapest	budapest	ADJ
admet-2753	60	25	,	,	PUNCT
admet-2753	60	26	hungary	hungary	PROPN
admet-2753	60	27	)	)	PUNCT
admet-2753	60	28	,	,	PUNCT
admet-2753	60	29	prismatm	prismatm	NOUN
admet-2753	60	30	ht	ht	PROPN
admet-2753	60	31	universal	universal	ADJ
admet-2753	60	32	buffer	buffer	NOUN
admet-2753	60	33	concentrate	concentrate	NOUN
admet-2753	60	34	(	(	PUNCT
admet-2753	60	35	suggested	suggest	VERB
admet-2753	60	36	working	work	VERB
admet-2753	60	37	ph	ph	ADJ
admet-2753	60	38	range	range	NOUN
admet-2753	60	39	between	between	ADP
admet-2753	60	40	3	3	NUM
admet-2753	60	41	and	and	CCONJ
admet-2753	60	42	10	10	NUM
admet-2753	60	43	)	)	PUNCT
admet-2753	60	44	,	,	PUNCT
admet-2753	60	45	which	which	PRON
admet-2753	60	46	is	be	AUX
admet-2753	60	47	a	a	DET
admet-2753	60	48	commercially	commercially	ADV
admet-2753	60	49	available	available	ADJ
admet-2753	60	50	ready	ready	ADJ
admet-2753	60	51	-	-	PUNCT
admet-2753	60	52	to	to	ADP
admet-2753	60	53	-	-	PUNCT
admet-2753	60	54	use	use	NOUN
admet-2753	60	55	buffer	buffer	NOUN
admet-2753	60	56	solution	solution	NOUN
admet-2753	60	57	was	be	AUX
admet-2753	60	58	obtained	obtain	VERB
admet-2753	60	59	from	from	ADP
admet-2753	60	60	pion	pion	PROPN
admet-2753	60	61	inc	inc	PROPN
admet-2753	60	62	.	.	PROPN
admet-2753	60	63	(	(	PUNCT
admet-2753	60	64	billerica	billerica	PROPN
admet-2753	60	65	,	,	PUNCT
admet-2753	60	66	ma	ma	PROPN
admet-2753	60	67	,	,	PUNCT
admet-2753	60	68	usa	usa	PROPN
admet-2753	60	69	)	)	PUNCT
admet-2753	60	70	and	and	CCONJ
admet-2753	60	71	n	n	CCONJ
admet-2753	60	72	-	-	PUNCT
admet-2753	60	73	dodecane	dodecane	NOUN
admet-2753	60	74	from	from	ADP
admet-2753	60	75	sigma	sigma	PROPN
admet-2753	60	76	-	-	PUNCT
admet-2753	60	77	aldrich	aldrich	PROPN
admet-2753	60	78	(	(	PUNCT
admet-2753	60	79	st	st	PROPN
admet-2753	60	80	.	.	PROPN
admet-2753	60	81	louis	louis	PROPN
admet-2753	60	82	,	,	PUNCT
admet-2753	60	83	missouri	missouri	PROPN
admet-2753	60	84	,	,	PUNCT
admet-2753	60	85	usa	usa	PROPN
admet-2753	60	86	)	)	PUNCT
admet-2753	60	87	.	.	PUNCT
admet-2753	61	1	1	1	NUM
admet-2753	61	2	and	and	CCONJ
admet-2753	61	3	6	6	NUM
admet-2753	61	4	to	to	PART
admet-2753	61	5	8	8	NUM
admet-2753	61	6	kda	kda	NOUN
admet-2753	61	7	mwco	mwco	NOUN
admet-2753	61	8	(	(	PUNCT
admet-2753	61	9	the	the	DET
admet-2753	61	10	mwco	mwco	NOUN
admet-2753	61	11	of	of	ADP
admet-2753	61	12	the	the	DET
admet-2753	61	13	membrane	membrane	NOUN
admet-2753	61	14	is	be	AUX
admet-2753	61	15	determined	determine	VERB
admet-2753	61	16	as	as	ADP
admet-2753	61	17	the	the	DET
admet-2753	61	18	molecular	molecular	ADJ
admet-2753	61	19	weight	weight	NOUN
admet-2753	61	20	of	of	ADP
admet-2753	61	21	the	the	DET
admet-2753	61	22	smallest	small	ADJ
admet-2753	61	23	solute	solute	NOUN
admet-2753	61	24	which	which	PRON
admet-2753	61	25	is	be	AUX
admet-2753	61	26	at	at	ADV
admet-2753	61	27	least	least	ADV
admet-2753	61	28	90	90	NUM
admet-2753	61	29	%	%	NOUN
admet-2753	61	30	retained	retain	VERB
admet-2753	61	31	during	during	ADP
admet-2753	61	32	the	the	DET
admet-2753	61	33	test	test	NOUN
admet-2753	61	34	(	(	PUNCT
admet-2753	61	35	the	the	DET
admet-2753	61	36	smallest	small	ADJ
admet-2753	61	37	solute	solute	NOUN
admet-2753	61	38	for	for	ADP
admet-2753	61	39	which	which	PRON
admet-2753	61	40	the	the	DET
admet-2753	61	41	permeation	permeation	NOUN
admet-2753	61	42	is	be	AUX
admet-2753	61	43	10	10	NUM
admet-2753	61	44	%	%	NOUN
admet-2753	61	45	or	or	CCONJ
admet-2753	61	46	less	less	ADJ
admet-2753	61	47	)	)	PUNCT
admet-2753	61	48	regenerated	regenerated	ADJ
admet-2753	61	49	cellulose	cellulose	NOUN
admet-2753	61	50	size	size	NOUN
admet-2753	61	51	-	-	PUNCT
admet-2753	61	52	exclusion	exclusion	NOUN
admet-2753	61	53	membrane	membrane	NOUN
admet-2753	61	54	were	be	AUX
admet-2753	61	55	purchased	purchase	VERB
admet-2753	61	56	from	from	ADP
admet-2753	61	57	repligen	repligen	PROPN
admet-2753	61	58	(	(	PUNCT
admet-2753	61	59	boston	boston	PROPN
admet-2753	61	60	,	,	PUNCT
admet-2753	61	61	ma	ma	PROPN
admet-2753	61	62	,	,	PUNCT
admet-2753	61	63	usa	usa	PROPN
admet-2753	61	64	)	)	PUNCT
admet-2753	61	65	.	.	PUNCT
admet-2753	62	1	polyvinylidene	polyvinylidene	NOUN
admet-2753	62	2	fluoride	fluoride	NOUN
admet-2753	62	3	(	(	PUNCT
admet-2753	62	4	pvdf	pvdf	PROPN
admet-2753	62	5	)	)	PUNCT
admet-2753	62	6	sheet	sheet	NOUN
admet-2753	62	7	with	with	ADP
admet-2753	62	8	0.45	0.45	NUM
admet-2753	62	9	µm	µm	ADP
admet-2753	62	10	pore	pore	ADJ
admet-2753	62	11	size	size	NOUN
admet-2753	62	12	was	be	AUX
admet-2753	62	13	obtained	obtain	VERB
admet-2753	62	14	from	from	ADP
admet-2753	62	15	pion	pion	PROPN
admet-2753	62	16	inc	inc	PROPN
admet-2753	62	17	.	.	PROPN
admet-2753	63	1	(	(	PUNCT
admet-2753	63	2	billerica	billerica	PROPN
admet-2753	63	3	,	,	PUNCT
admet-2753	63	4	ma	ma	PROPN
admet-2753	63	5	,	,	PUNCT
admet-2753	63	6	usa	usa	PROPN
admet-2753	63	7	)	)	PUNCT
admet-2753	63	8	.	.	PUNCT
admet-2753	64	1	determination	determination	NOUN
admet-2753	64	2	of	of	ADP
admet-2753	64	3	the	the	DET
admet-2753	64	4	limiting	limit	VERB
admet-2753	64	5	step	step	NOUN
admet-2753	64	6	of	of	ADP
admet-2753	64	7	membrane	membrane	NOUN
admet-2753	64	8	transport	transport	NOUN
admet-2753	64	9	the	the	DET
admet-2753	64	10	in	in	ADP
admet-2753	64	11	vitro	vitro	X
admet-2753	64	12	side	side	NOUN
admet-2753	64	13	-	-	PUNCT
admet-2753	64	14	by	by	ADP
admet-2753	64	15	-	-	PUNCT
admet-2753	64	16	side	side	NOUN
admet-2753	64	17	diffusion	diffusion	NOUN
admet-2753	64	18	cell	cell	NOUN
admet-2753	64	19	assays	assay	NOUN
admet-2753	64	20	were	be	AUX
admet-2753	64	21	performed	perform	VERB
admet-2753	64	22	using	use	VERB
admet-2753	64	23	µflux	µflux	NOUN
admet-2753	64	24	™	™	ADJ
admet-2753	64	25	apparatus	apparatus	NOUN
admet-2753	64	26	(	(	PUNCT
admet-2753	64	27	pion	pion	PROPN
admet-2753	64	28	inc	inc	PROPN
admet-2753	64	29	.	.	PROPN
admet-2753	64	30	,	,	PUNCT
admet-2753	64	31	billerica	billerica	PROPN
admet-2753	64	32	ma	ma	PROPN
admet-2753	64	33	,	,	PUNCT
admet-2753	64	34	usa	usa	PROPN
admet-2753	64	35	)	)	PUNCT
admet-2753	64	36	to	to	PART
admet-2753	64	37	determine	determine	VERB
admet-2753	64	38	uwl	uwl	NOUN
admet-2753	64	39	thickness	thickness	NOUN
admet-2753	64	40	.	.	PUNCT
admet-2753	65	1	it	it	PRON
admet-2753	65	2	consists	consist	VERB
admet-2753	65	3	of	of	ADP
admet-2753	65	4	a	a	DET
admet-2753	65	5	donor	donor	NOUN
admet-2753	65	6	and	and	CCONJ
admet-2753	65	7	an	an	DET
admet-2753	65	8	acceptor	acceptor	NOUN
admet-2753	65	9	chamber	chamber	NOUN
admet-2753	65	10	(	(	PUNCT
admet-2753	65	11	20	20	NUM
admet-2753	65	12	ml	ml	PROPN
admet-2753	65	13	volumes	volume	NOUN
admet-2753	65	14	of	of	ADP
admet-2753	65	15	plain	plain	ADJ
admet-2753	65	16	buffer	buffer	NOUN
admet-2753	65	17	or	or	CCONJ
admet-2753	65	18	buffer	buffer	VERB
admet-2753	65	19	with	with	ADP
admet-2753	65	20	hp	hp	ADJ
admet-2753	65	21	-	-	PUNCT
admet-2753	65	22	β	β	NOUN
admet-2753	65	23	-	-	NOUN
admet-2753	65	24	cd	cd	NOUN
admet-2753	65	25	on	on	ADP
admet-2753	65	26	the	the	DET
admet-2753	65	27	donor	donor	NOUN
admet-2753	65	28	side	side	NOUN
admet-2753	65	29	and	and	CCONJ
admet-2753	65	30	plain	plain	ADJ
admet-2753	65	31	buffer	buffer	NOUN
admet-2753	65	32	on	on	ADP
admet-2753	65	33	the	the	DET
admet-2753	65	34	acceptor	acceptor	NOUN
admet-2753	65	35	side	side	NOUN
admet-2753	65	36	)	)	PUNCT
admet-2753	65	37	separated	separate	VERB
admet-2753	65	38	by	by	ADP
admet-2753	65	39	an	an	DET
admet-2753	65	40	artificial	artificial	ADJ
admet-2753	65	41	membrane	membrane	NOUN
admet-2753	65	42	selected	select	VERB
admet-2753	65	43	to	to	PART
admet-2753	65	44	be	be	AUX
admet-2753	65	45	a	a	DET
admet-2753	65	46	lipophilic	lipophilic	ADJ
admet-2753	65	47	membrane	membrane	NOUN
admet-2753	65	48	(	(	PUNCT
admet-2753	65	49	0.45	0.45	NUM
admet-2753	65	50	µm	µm	ADP
admet-2753	65	51	pore	pore	ADJ
admet-2753	65	52	size	size	NOUN
admet-2753	65	53	pvdf	pvdf	PROPN
admet-2753	65	54	sheet	sheet	NOUN
admet-2753	65	55	impregnated	impregnate	VERB
admet-2753	65	56	with	with	ADP
admet-2753	65	57	25	25	NUM
admet-2753	65	58	μl	μl	ADJ
admet-2753	65	59	n	n	CCONJ
admet-2753	65	60	-	-	PUNCT
admet-2753	65	61	dodecane	dodecane	NOUN
admet-2753	65	62	)	)	PUNCT
admet-2753	65	63	,	,	PUNCT
admet-2753	65	64	1	1	NUM
admet-2753	65	65	or	or	CCONJ
admet-2753	65	66	6	6	NUM
admet-2753	65	67	kda	kda	NOUN
admet-2753	65	68	size	size	NOUN
admet-2753	65	69	-	-	PUNCT
admet-2753	65	70	exclusion	exclusion	NOUN
admet-2753	65	71	membrane	membrane	NOUN
admet-2753	65	72	.	.	PUNCT
admet-2753	66	1	the	the	DET
admet-2753	66	2	transport	transport	NOUN
admet-2753	66	3	of	of	ADP
admet-2753	66	4	car	car	NOUN
admet-2753	66	5	across	across	ADP
admet-2753	66	6	the	the	DET
admet-2753	66	7	different	different	ADJ
admet-2753	66	8	membranes	membrane	NOUN
admet-2753	66	9	was	be	AUX
admet-2753	66	10	investigated	investigate	VERB
admet-2753	66	11	at	at	ADP
admet-2753	66	12	different	different	ADJ
admet-2753	66	13	ph	ph	ADJ
admet-2753	66	14	values	value	NOUN
admet-2753	66	15	and	and	CCONJ
admet-2753	66	16	stirring	stir	VERB
admet-2753	66	17	speeds	speed	NOUN
admet-2753	66	18	(	(	PUNCT
admet-2753	66	19	table	table	NOUN
admet-2753	66	20	1	1	NUM
admet-2753	66	21	)	)	PUNCT
admet-2753	66	22	.	.	PUNCT
admet-2753	67	1	table	table	NOUN
admet-2753	67	2	1	1	NUM
admet-2753	67	3	.	.	PUNCT
admet-2753	68	1	parameters	parameter	NOUN
admet-2753	68	2	of	of	ADP
admet-2753	68	3	the	the	DET
admet-2753	68	4	uwl	uwl	NOUN
admet-2753	68	5	thickness	thickness	NOUN
admet-2753	68	6	measurement	measurement	NOUN
admet-2753	68	7	in	in	ADP
admet-2753	68	8	the	the	DET
admet-2753	68	9	case	case	NOUN
admet-2753	68	10	of	of	ADP
admet-2753	68	11	lipophilic	lipophilic	ADJ
admet-2753	68	12	membrane	membrane	NOUN
admet-2753	68	13	with	with	ADP
admet-2753	68	14	different	different	ADJ
admet-2753	68	15	ph	ph	ADJ
admet-2753	68	16	values	value	NOUN
admet-2753	68	17	and	and	CCONJ
admet-2753	68	18	stirring	stir	VERB
admet-2753	68	19	rates	rate	NOUN
admet-2753	68	20	membrane	membrane	ADJ
admet-2753	68	21	ph	ph	ADJ
admet-2753	68	22	stirring	stirring	NOUN
admet-2753	68	23	rates	rate	NOUN
admet-2753	68	24	,	,	PUNCT
admet-2753	68	25	rpm	rpm	NOUN
admet-2753	68	26	content	content	NOUN
admet-2753	68	27	of	of	ADP
admet-2753	68	28	neutral	neutral	ADJ
admet-2753	68	29	form	form	NOUN
admet-2753	68	30	of	of	ADP
admet-2753	68	31	carvedilol	carvedilol	NOUN
admet-2753	68	32	,	,	PUNCT
admet-2753	68	33	%	%	NOUN
admet-2753	68	34	lipophilic	lipophilic	PROPN
admet-2753	68	35	10.0	10.0	NUM
admet-2753	68	36	0	0	NUM
admet-2753	68	37	;	;	PUNCT
admet-2753	68	38	25	25	NUM
admet-2753	68	39	;	;	PUNCT
admet-2753	68	40	50	50	NUM
admet-2753	68	41	;	;	PUNCT
admet-2753	68	42	100	100	NUM
admet-2753	68	43	;	;	PUNCT
admet-2753	68	44	250	250	NUM
admet-2753	68	45	;	;	PUNCT
admet-2753	68	46	400	400	NUM
admet-2753	68	47	;	;	PUNCT
admet-2753	68	48	600	600	NUM
admet-2753	68	49	99.4	99.4	NUM
admet-2753	68	50	9.5	9.5	NUM
admet-2753	68	51	25	25	NUM
admet-2753	68	52	;	;	PUNCT
admet-2753	68	53	50	50	NUM
admet-2753	68	54	;	;	PUNCT
admet-2753	68	55	100	100	NUM
admet-2753	68	56	;	;	PUNCT
admet-2753	68	57	250	250	NUM
admet-2753	68	58	98.0	98.0	NUM
admet-2753	68	59	7.0	7.0	NUM
admet-2753	68	60	25	25	NUM
admet-2753	68	61	;	;	PUNCT
admet-2753	68	62	50	50	NUM
admet-2753	68	63	;	;	PUNCT
admet-2753	68	64	100	100	NUM
admet-2753	68	65	;	;	PUNCT
admet-2753	68	66	250	250	NUM
admet-2753	68	67	13.7	13.7	NUM
admet-2753	68	68	6.0	6.0	NUM
admet-2753	68	69	25	25	NUM
admet-2753	68	70	;	;	PUNCT
admet-2753	68	71	50	50	NUM
admet-2753	68	72	;	;	PUNCT
admet-2753	68	73	100	100	NUM
admet-2753	68	74	;	;	PUNCT
admet-2753	68	75	250	250	NUM
admet-2753	68	76	1.6	1.6	NUM
admet-2753	68	77	5.0	5.0	NUM
admet-2753	68	78	25	25	NUM
admet-2753	68	79	;	;	PUNCT
admet-2753	68	80	50	50	NUM
admet-2753	68	81	;	;	PUNCT
admet-2753	68	82	100	100	NUM
admet-2753	68	83	;	;	PUNCT
admet-2753	68	84	250	250	NUM
admet-2753	68	85	0.2	0.2	NUM
admet-2753	68	86	size	size	NOUN
admet-2753	68	87	-	-	PUNCT
admet-2753	68	88	exclusion	exclusion	NOUN
admet-2753	68	89	10.0	10.0	NUM
admet-2753	68	90	0	0	NUM
admet-2753	68	91	;	;	PUNCT
admet-2753	68	92	100	100	NUM
admet-2753	68	93	;	;	PUNCT
admet-2753	68	94	250	250	NUM
admet-2753	68	95	;	;	PUNCT
admet-2753	68	96	400	400	NUM
admet-2753	68	97	99.4	99.4	NUM
admet-2753	68	98	6.0	6.0	NUM
admet-2753	68	99	250	250	NUM
admet-2753	68	100	1.6	1.6	NUM
admet-2753	68	101	a	a	DET
admet-2753	68	102	lipophilic	lipophilic	ADJ
admet-2753	68	103	membrane	membrane	NOUN
admet-2753	68	104	(	(	PUNCT
admet-2753	68	105	pvdf	pvdf	NOUN
admet-2753	68	106	sheet	sheet	NOUN
admet-2753	68	107	,	,	PUNCT
admet-2753	68	108	0.45	0.45	NUM
admet-2753	68	109	µm	µm	ADP
admet-2753	68	110	pore	pore	ADJ
admet-2753	68	111	size	size	NOUN
admet-2753	68	112	)	)	PUNCT
admet-2753	68	113	impregnated	impregnate	VERB
admet-2753	68	114	with	with	ADP
admet-2753	68	115	25	25	NUM
admet-2753	68	116	µl	µl	ADP
admet-2753	68	117	n	n	NOUN
admet-2753	68	118	-	-	PUNCT
admet-2753	68	119	dodecane	dodecane	NOUN
admet-2753	68	120	was	be	AUX
admet-2753	68	121	placed	place	VERB
admet-2753	68	122	in	in	ADP
admet-2753	68	123	the	the	DET
admet-2753	68	124	membrane	membrane	NOUN
admet-2753	68	125	holder	holder	NOUN
admet-2753	68	126	connecting	connect	VERB
admet-2753	68	127	the	the	DET
admet-2753	68	128	donor	donor	NOUN
admet-2753	68	129	and	and	CCONJ
admet-2753	68	130	acceptor	acceptor	NOUN
admet-2753	68	131	cells	cell	NOUN
admet-2753	68	132	.	.	PUNCT
admet-2753	69	1	18	18	NUM
admet-2753	69	2	ml	ml	NOUN
admet-2753	69	3	of	of	ADP
admet-2753	69	4	prisma	prisma	NOUN
admet-2753	69	5	buffer	buffer	NOUN
admet-2753	69	6	,	,	PUNCT
admet-2753	69	7	adjusted	adjust	VERB
admet-2753	69	8	to	to	ADP
admet-2753	69	9	the	the	DET
admet-2753	69	10	appropriate	appropriate	ADJ
admet-2753	69	11	ph	ph	NOUN
admet-2753	69	12	,	,	PUNCT
admet-2753	69	13	was	be	AUX
admet-2753	69	14	pipetted	pipette	VERB
admet-2753	69	15	into	into	ADP
admet-2753	69	16	the	the	DET
admet-2753	69	17	donor	donor	NOUN
admet-2753	69	18	and	and	CCONJ
admet-2753	69	19	acceptor	acceptor	NOUN
admet-2753	69	20	sides	side	NOUN
admet-2753	69	21	.	.	PUNCT
admet-2753	70	1	the	the	DET
admet-2753	70	2	appropriate	appropriate	ADJ
admet-2753	70	3	amount	amount	NOUN
admet-2753	70	4	of	of	ADP
admet-2753	70	5	the	the	DET
admet-2753	70	6	3	3	NUM
admet-2753	70	7	mg	mg	NOUN
admet-2753	70	8	ml-1	ml-1	CCONJ
admet-2753	70	9	methanol	methanol	NOUN
admet-2753	70	10	stock	stock	NOUN
admet-2753	70	11	solution	solution	NOUN
admet-2753	70	12	of	of	ADP
admet-2753	70	13	car	car	NOUN
admet-2753	70	14	was	be	AUX
admet-2753	70	15	added	add	VERB
admet-2753	70	16	to	to	ADP
admet-2753	70	17	the	the	DET
admet-2753	70	18	donor	donor	NOUN
admet-2753	70	19	side	side	NOUN
admet-2753	70	20	.	.	PUNCT
admet-2753	71	1	the	the	DET
admet-2753	71	2	target	target	NOUN
admet-2753	71	3	concentrations	concentration	NOUN
admet-2753	71	4	were	be	AUX
admet-2753	71	5	20	20	NUM
admet-2753	71	6	,	,	PUNCT
admet-2753	71	7	10	10	NUM
admet-2753	71	8	,	,	PUNCT
admet-2753	71	9	50	50	NUM
admet-2753	71	10	and	and	CCONJ
admet-2753	71	11	admet	admet	PROPN
admet-2753	71	12	&	&	CCONJ
admet-2753	71	13	dmpk	dmpk	PROPN
admet-2753	71	14	13(4	13(4	NUM
admet-2753	71	15	)	)	PUNCT
admet-2753	71	16	(	(	PUNCT
admet-2753	71	17	2025	2025	NUM
admet-2753	71	18	)	)	PUNCT
admet-2753	71	19	2753	2753	NUM
admet-2753	71	20	comparison	comparison	NOUN
admet-2753	71	21	of	of	ADP
admet-2753	71	22	lipophilic	lipophilic	ADJ
admet-2753	71	23	and	and	CCONJ
admet-2753	71	24	size	size	NOUN
admet-2753	71	25	-	-	PUNCT
admet-2753	71	26	exclusion	exclusion	NOUN
admet-2753	71	27	membranes	membrane	NOUN
admet-2753	71	28	doi	doi	NOUN
admet-2753	71	29	:	:	PUNCT
admet-2753	71	30	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	71	31	5	5	NUM
admet-2753	71	32	50	50	NUM
admet-2753	71	33	mg	mg	NOUN
admet-2753	71	34	ml-1	ml-1	ADV
admet-2753	71	35	for	for	ADP
admet-2753	71	36	ph	ph	ADJ
admet-2753	71	37	10	10	NUM
admet-2753	71	38	,	,	PUNCT
admet-2753	71	39	ph	ph	ADJ
admet-2753	71	40	9.5	9.5	NUM
admet-2753	71	41	,	,	PUNCT
admet-2753	71	42	ph	ph	ADJ
admet-2753	71	43	7	7	NUM
admet-2753	71	44	,	,	PUNCT
admet-2753	71	45	and	and	CCONJ
admet-2753	71	46	ph	ph	ADJ
admet-2753	71	47	6	6	NUM
admet-2753	71	48	,	,	PUNCT
admet-2753	71	49	respectively	respectively	ADV
admet-2753	71	50	.	.	PUNCT
admet-2753	72	1	methanol	methanol	NOUN
admet-2753	72	2	was	be	AUX
admet-2753	72	3	pipetted	pipette	VERB
admet-2753	72	4	to	to	ADP
admet-2753	72	5	the	the	DET
admet-2753	72	6	acceptor	acceptor	NOUN
admet-2753	72	7	side	side	NOUN
admet-2753	72	8	in	in	ADP
admet-2753	72	9	the	the	DET
admet-2753	72	10	same	same	ADJ
admet-2753	72	11	amount	amount	NOUN
admet-2753	72	12	as	as	SCONJ
admet-2753	72	13	that	that	PRON
admet-2753	72	14	added	add	VERB
admet-2753	72	15	to	to	ADP
admet-2753	72	16	the	the	DET
admet-2753	72	17	donor	donor	NOUN
admet-2753	72	18	side	side	NOUN
admet-2753	72	19	.	.	PUNCT
admet-2753	73	1	to	to	PART
admet-2753	73	2	ensure	ensure	VERB
admet-2753	73	3	that	that	SCONJ
admet-2753	73	4	the	the	DET
admet-2753	73	5	starting	starting	NOUN
admet-2753	73	6	solution	solution	NOUN
admet-2753	73	7	was	be	AUX
admet-2753	73	8	homogeneous	homogeneous	ADJ
admet-2753	73	9	in	in	ADP
admet-2753	73	10	all	all	DET
admet-2753	73	11	cases	case	NOUN
admet-2753	73	12	,	,	PUNCT
admet-2753	73	13	both	both	CCONJ
admet-2753	73	14	the	the	DET
admet-2753	73	15	donor	donor	NOUN
admet-2753	73	16	and	and	CCONJ
admet-2753	73	17	acceptor	acceptor	NOUN
admet-2753	73	18	sides	side	NOUN
admet-2753	73	19	were	be	AUX
admet-2753	73	20	stirred	stir	VERB
admet-2753	73	21	at	at	ADP
admet-2753	73	22	250	250	NUM
admet-2753	73	23	rpm	rpm	NOUN
admet-2753	73	24	for	for	ADP
admet-2753	73	25	1	1	NUM
admet-2753	73	26	min	min	NOUN
admet-2753	73	27	,	,	PUNCT
admet-2753	73	28	and	and	CCONJ
admet-2753	73	29	then	then	ADV
admet-2753	73	30	the	the	DET
admet-2753	73	31	specified	specified	ADJ
admet-2753	73	32	stirring	stirring	NOUN
admet-2753	73	33	speed	speed	NOUN
admet-2753	73	34	(	(	PUNCT
admet-2753	73	35	table	table	NOUN
admet-2753	73	36	1	1	NUM
admet-2753	73	37	)	)	PUNCT
admet-2753	73	38	was	be	AUX
admet-2753	73	39	set	set	VERB
admet-2753	73	40	.	.	PUNCT
admet-2753	74	1	the	the	DET
admet-2753	74	2	concentration	concentration	NOUN
admet-2753	74	3	of	of	ADP
admet-2753	74	4	car	car	NOUN
admet-2753	74	5	on	on	ADP
admet-2753	74	6	both	both	CCONJ
admet-2753	74	7	the	the	DET
admet-2753	74	8	donor	donor	NOUN
admet-2753	74	9	and	and	CCONJ
admet-2753	74	10	acceptor	acceptor	NOUN
admet-2753	74	11	sides	side	NOUN
admet-2753	74	12	was	be	AUX
admet-2753	74	13	measured	measure	VERB
admet-2753	74	14	in	in	ADP
admet-2753	74	15	real	real	ADJ
admet-2753	74	16	-	-	PUNCT
admet-2753	74	17	time	time	NOUN
admet-2753	74	18	using	use	VERB
admet-2753	74	19	uv	uv	NOUN
admet-2753	74	20	probes	probe	NOUN
admet-2753	74	21	.	.	PUNCT
admet-2753	75	1	the	the	DET
admet-2753	75	2	measurements	measurement	NOUN
admet-2753	75	3	were	be	AUX
admet-2753	75	4	performed	perform	VERB
admet-2753	75	5	at	at	ADP
admet-2753	75	6	37	37	NUM
admet-2753	75	7	°	°	NOUN
admet-2753	75	8	c	c	NOUN
admet-2753	75	9	.	.	PUNCT
admet-2753	76	1	the	the	DET
admet-2753	76	2	spectra	spectra	PROPN
admet-2753	76	3	obtained	obtain	VERB
admet-2753	76	4	were	be	AUX
admet-2753	76	5	evaluated	evaluate	VERB
admet-2753	76	6	by	by	ADP
admet-2753	76	7	the	the	DET
admet-2753	76	8	second	second	ADJ
admet-2753	76	9	derivative	derivative	ADJ
admet-2753	76	10	method	method	NOUN
admet-2753	76	11	between	between	ADP
admet-2753	76	12	292	292	NUM
admet-2753	76	13	and	and	CCONJ
admet-2753	76	14	300	300	NUM
admet-2753	76	15	nm	nm	NOUN
admet-2753	76	16	,	,	PUNCT
admet-2753	76	17	and	and	CCONJ
admet-2753	76	18	the	the	DET
admet-2753	76	19	apparent	apparent	ADJ
admet-2753	76	20	permeability	permeability	NOUN
admet-2753	76	21	(	(	PUNCT
admet-2753	76	22	papp	papp	NOUN
admet-2753	76	23	)	)	PUNCT
admet-2753	76	24	was	be	AUX
admet-2753	76	25	calculated	calculate	VERB
admet-2753	76	26	[	[	X
admet-2753	76	27	9	9	NUM
admet-2753	76	28	]	]	PUNCT
admet-2753	76	29	according	accord	VERB
admet-2753	76	30	to	to	ADP
admet-2753	76	31	equation	equation	NOUN
admet-2753	76	32	(	(	PUNCT
admet-2753	76	33	1	1	NUM
admet-2753	76	34	)	)	PUNCT
admet-2753	76	35	as	as	SCONJ
admet-2753	76	36	follows	follow	VERB
admet-2753	76	37	:	:	PUNCT
admet-2753	77	1	app	app	PROPN
admet-2753	78	1	d	d	PROPN
admet-2753	78	2	d	d	PROPN
admet-2753	78	3	1	1	NUM
admet-2753	78	4	n	n	PROPN
admet-2753	78	5	a	a	DET
admet-2753	78	6	tp	tp	NOUN
admet-2753	78	7	c	c	PROPN
admet-2753	78	8	c	c	NOUN
admet-2753	78	9			NOUN
admet-2753	78	10	=	=	PROPN
admet-2753	78	11	=	=	SYM
admet-2753	78	12	(	(	PUNCT
admet-2753	78	13	1	1	NUM
admet-2753	78	14	)	)	PUNCT
admet-2753	78	15	where	where	SCONJ
admet-2753	78	16	flux	flux	NOUN
admet-2753	78	17	(	(	PUNCT
admet-2753	78	18	j	j	NOUN
admet-2753	78	19	)	)	PUNCT
admet-2753	78	20	of	of	ADP
admet-2753	78	21	a	a	DET
admet-2753	78	22	drug	drug	NOUN
admet-2753	78	23	through	through	ADP
admet-2753	78	24	the	the	DET
admet-2753	78	25	membrane	membrane	NOUN
admet-2753	78	26	is	be	AUX
admet-2753	78	27	defined	define	VERB
admet-2753	78	28	as	as	ADP
admet-2753	78	29	the	the	DET
admet-2753	78	30	amount	amount	NOUN
admet-2753	78	31	(	(	PUNCT
admet-2753	78	32	n	n	CCONJ
admet-2753	78	33	)	)	PUNCT
admet-2753	78	34	of	of	ADP
admet-2753	78	35	the	the	DET
admet-2753	78	36	drug	drug	NOUN
admet-2753	78	37	crossing	cross	VERB
admet-2753	78	38	a	a	DET
admet-2753	78	39	unit	unit	NOUN
admet-2753	78	40	area	area	NOUN
admet-2753	78	41	(	(	PUNCT
admet-2753	78	42	a	a	NOUN
admet-2753	78	43	)	)	PUNCT
admet-2753	78	44	perpendicular	perpendicular	NOUN
admet-2753	78	45	to	to	ADP
admet-2753	78	46	its	its	PRON
admet-2753	78	47	flow	flow	NOUN
admet-2753	78	48	per	per	ADP
admet-2753	78	49	unit	unit	NOUN
admet-2753	78	50	time	time	NOUN
admet-2753	78	51	(	(	PUNCT
admet-2753	78	52	t	t	NOUN
admet-2753	78	53	)	)	PUNCT
admet-2753	78	54	.	.	PUNCT
admet-2753	79	1	cd	cd	PROPN
admet-2753	79	2	is	be	AUX
admet-2753	79	3	the	the	DET
admet-2753	79	4	concentration	concentration	NOUN
admet-2753	79	5	of	of	ADP
admet-2753	79	6	the	the	DET
admet-2753	79	7	drug	drug	NOUN
admet-2753	79	8	at	at	ADP
admet-2753	79	9	the	the	DET
admet-2753	79	10	donor	donor	NOUN
admet-2753	79	11	side	side	NOUN
admet-2753	79	12	.	.	PUNCT
admet-2753	80	1	the	the	DET
admet-2753	80	2	membrane	membrane	NOUN
admet-2753	80	3	permeability	permeability	NOUN
admet-2753	80	4	of	of	ADP
admet-2753	80	5	the	the	DET
admet-2753	80	6	unbound	unbound	NOUN
admet-2753	80	7	(	(	PUNCT
admet-2753	80	8	u	u	NOUN
admet-2753	80	9	)	)	PUNCT
admet-2753	80	10	and	and	CCONJ
admet-2753	80	11	unionized	unionized	ADJ
admet-2753	80	12	drug	drug	NOUN
admet-2753	80	13	(	(	PUNCT
admet-2753	80	14	pmembrane	pmembrane	NOUN
admet-2753	80	15	,	,	PUNCT
admet-2753	80	16	lipophilic	lipophilic	NOUN
admet-2753	80	17	,	,	PUNCT
admet-2753	80	18	u,0	u,0	PROPN
admet-2753	80	19	)	)	PUNCT
admet-2753	80	20	was	be	AUX
admet-2753	80	21	determined	determine	VERB
admet-2753	80	22	using	use	VERB
admet-2753	80	23	the	the	DET
admet-2753	80	24	gutknecht	gutknecht	ADJ
admet-2753	80	25	method	method	NOUN
admet-2753	81	1	[	[	X
admet-2753	81	2	42	42	NUM
admet-2753	81	3	-	-	SYM
admet-2753	81	4	45	45	NUM
admet-2753	81	5	]	]	PUNCT
admet-2753	81	6	based	base	VERB
admet-2753	81	7	on	on	ADP
admet-2753	81	8	the	the	DET
admet-2753	81	9	measured	measure	VERB
admet-2753	81	10	apparent	apparent	ADJ
admet-2753	81	11	permeability	permeability	NOUN
admet-2753	81	12	.	.	PUNCT
admet-2753	82	1	quasi	quasi	ADJ
admet-2753	82	2	-	-	ADJ
admet-2753	82	3	equilibrium	equilibrium	ADJ
admet-2753	82	4	model	model	NOUN
admet-2753	82	5	used	use	VERB
admet-2753	82	6	to	to	PART
admet-2753	82	7	determine	determine	VERB
admet-2753	82	8	the	the	DET
admet-2753	82	9	uwl	uwl	NOUN
admet-2753	82	10	permeability	permeability	NOUN
admet-2753	82	11	of	of	ADP
admet-2753	82	12	the	the	DET
admet-2753	82	13	drug	drug	NOUN
admet-2753	82	14	in	in	ADP
admet-2753	82	15	the	the	DET
admet-2753	82	16	presence	presence	NOUN
admet-2753	82	17	and	and	CCONJ
admet-2753	82	18	absence	absence	NOUN
admet-2753	82	19	of	of	ADP
admet-2753	82	20	cyclodextrin	cyclodextrin	NOUN
admet-2753	83	1	[	[	X
admet-2753	83	2	46	46	NUM
admet-2753	83	3	]	]	X
admet-2753	83	4	:	:	PUNCT
admet-2753	83	5	the	the	DET
admet-2753	83	6	assumptions	assumption	NOUN
admet-2753	83	7	of	of	ADP
admet-2753	83	8	the	the	DET
admet-2753	83	9	analysis	analysis	NOUN
admet-2753	83	10	:	:	PUNCT
admet-2753	83	11	a	a	X
admet-2753	83	12	)	)	PUNCT
admet-2753	83	13	quasi	quasi	ADJ
admet-2753	83	14	-	-	ADJ
admet-2753	83	15	equilibrium	equilibrium	NOUN
admet-2753	83	16	conditions	condition	NOUN
admet-2753	83	17	,	,	PUNCT
admet-2753	83	18	b	b	X
admet-2753	83	19	)	)	PUNCT
admet-2753	83	20	1:1	1:1	NUM
admet-2753	83	21	stoichiometry	stoichiometry	NOUN
admet-2753	83	22	between	between	ADP
admet-2753	83	23	car/	car/	NOUN
admet-2753	83	24	hp	hp	NOUN
admet-2753	83	25	-	-	PUNCT
admet-2753	83	26	β	β	NOUN
admet-2753	83	27	-	-	ADJ
admet-2753	83	28	cd	cd	ADJ
admet-2753	83	29	complex	complex	NOUN
admet-2753	83	30	,	,	PUNCT
admet-2753	83	31	c	c	NOUN
admet-2753	83	32	)	)	PUNCT
admet-2753	83	33	only	only	ADV
admet-2753	83	34	the	the	DET
admet-2753	83	35	free	free	ADJ
admet-2753	83	36	drug	drug	NOUN
admet-2753	83	37	partitions	partition	NOUN
admet-2753	83	38	and	and	CCONJ
admet-2753	83	39	diffuses	diffuse	NOUN
admet-2753	83	40	into	into	ADP
admet-2753	83	41	the	the	DET
admet-2753	83	42	membrane	membrane	NOUN
admet-2753	83	43	,	,	PUNCT
admet-2753	83	44	but	but	CCONJ
admet-2753	83	45	not	not	PART
admet-2753	83	46	the	the	DET
admet-2753	83	47	car/	car/	NOUN
admet-2753	83	48	hp	hp	NOUN
admet-2753	83	49	-	-	PUNCT
admet-2753	83	50	β	β	NOUN
admet-2753	83	51	-	-	ADJ
admet-2753	83	52	cd	cd	ADJ
admet-2753	83	53	complex	complex	NOUN
admet-2753	83	54	,	,	PUNCT
admet-2753	83	55	d	d	X
admet-2753	83	56	)	)	PUNCT
admet-2753	83	57	the	the	DET
admet-2753	83	58	presence	presence	NOUN
admet-2753	83	59	of	of	ADP
admet-2753	83	60	hp	hp	PROPN
admet-2753	83	61	-	-	PUNCT
admet-2753	83	62	β	β	NOUN
admet-2753	83	63	-	-	NOUN
admet-2753	83	64	cd	cd	NOUN
admet-2753	83	65	does	do	AUX
admet-2753	83	66	not	not	PART
admet-2753	83	67	affect	affect	VERB
admet-2753	83	68	the	the	DET
admet-2753	83	69	membrane	membrane	NOUN
admet-2753	83	70	thickness	thickness	NOUN
admet-2753	83	71	,	,	PUNCT
admet-2753	83	72	e	e	NOUN
admet-2753	83	73	)	)	PUNCT
admet-2753	83	74	only	only	ADV
admet-2753	83	75	the	the	DET
admet-2753	83	76	free	free	ADJ
admet-2753	83	77	drug	drug	NOUN
admet-2753	83	78	encounters	encounter	VERB
admet-2753	83	79	a	a	DET
admet-2753	83	80	significant	significant	ADJ
admet-2753	83	81	unstirred	unstirred	ADJ
admet-2753	83	82	water	water	NOUN
admet-2753	83	83	layer	layer	NOUN
admet-2753	83	84	thickness	thickness	NOUN
admet-2753	83	85	,	,	PUNCT
admet-2753	83	86	but	but	CCONJ
admet-2753	83	87	the	the	DET
admet-2753	83	88	unstirred	unstirred	ADJ
admet-2753	83	89	water	water	NOUN
admet-2753	83	90	layer	layer	NOUN
admet-2753	83	91	thickness	thickness	NOUN
admet-2753	83	92	is	be	AUX
admet-2753	83	93	negligible	negligible	ADJ
admet-2753	83	94	for	for	ADP
admet-2753	83	95	the	the	DET
admet-2753	83	96	car/	car/	NOUN
admet-2753	83	97	hp	hp	NOUN
admet-2753	83	98	-	-	PUNCT
admet-2753	83	99	β	β	NOUN
admet-2753	83	100	-	-	ADJ
admet-2753	83	101	cd	cd	ADJ
admet-2753	83	102	complex	complex	NOUN
admet-2753	83	103	.	.	PUNCT
admet-2753	84	1	puwl	puwl	PROPN
admet-2753	84	2	and	and	CCONJ
admet-2753	84	3	pmembrane	pmembrane	NOUN
admet-2753	84	4	were	be	AUX
admet-2753	84	5	calculated	calculate	VERB
admet-2753	84	6	using	use	VERB
admet-2753	84	7	equations	equation	NOUN
admet-2753	84	8	(	(	PUNCT
admet-2753	84	9	2	2	NUM
admet-2753	84	10	)	)	PUNCT
admet-2753	84	11	and	and	CCONJ
admet-2753	84	12	(	(	PUNCT
admet-2753	84	13	3	3	X
admet-2753	84	14	)	)	PUNCT
admet-2753	84	15	as	as	SCONJ
admet-2753	84	16	follows	follow	VERB
admet-2753	84	17	:	:	PUNCT
admet-2753	84	18	e	e	X
admet-2753	84	19	uwl	uwl	ADV
admet-2753	84	20	membrane	membrane	VERB
admet-2753	84	21	,	,	PUNCT
admet-2753	84	22	 	 	SPACE
admet-2753	84	23	lipophilic	lipophilic	ADJ
admet-2753	84	24	1	1	NUM
admet-2753	84	25	1	1	NUM
admet-2753	84	26	1	1	NUM
admet-2753	84	27	p	p	NOUN
admet-2753	84	28	p	p	X
admet-2753	84	29	p	p	X
admet-2753	85	1	=	=	X
admet-2753	86	1	+	+	CCONJ
admet-2753	87	1	(	(	PUNCT
admet-2753	87	2	2	2	X
admet-2753	87	3	)	)	PUNCT
admet-2753	87	4	e	e	NOUN
admet-2753	87	5	uwl	uwl	X
admet-2753	87	6	membrane	membrane	VERB
admet-2753	87	7	,	,	PUNCT
admet-2753	87	8	 	 	SPACE
admet-2753	87	9	size	size	NOUN
admet-2753	87	10	-	-	PUNCT
admet-2753	87	11	exclusion	exclusion	NOUN
admet-2753	87	12	1	1	NUM
admet-2753	87	13	1	1	NUM
admet-2753	87	14	1	1	NUM
admet-2753	87	15	p	p	NOUN
admet-2753	87	16	p	p	X
admet-2753	87	17	p	p	X
admet-2753	88	1	=	=	X
admet-2753	89	1	+	+	CCONJ
admet-2753	90	1	(	(	PUNCT
admet-2753	90	2	3	3	NUM
admet-2753	90	3	)	)	PUNCT
admet-2753	90	4	where	where	SCONJ
admet-2753	90	5	pmembrfane	pmembrfane	NOUN
admet-2753	90	6	,	,	PUNCT
admet-2753	90	7	lipophilic	lipophilic	ADJ
admet-2753	90	8	and	and	CCONJ
admet-2753	90	9	pmembrane	pmembrane	NOUN
admet-2753	90	10	,	,	PUNCT
admet-2753	90	11	size	size	NOUN
admet-2753	90	12	-	-	PUNCT
admet-2753	90	13	exclusion	exclusion	NOUN
admet-2753	90	14	are	be	AUX
admet-2753	90	15	the	the	DET
admet-2753	90	16	membrane	membrane	NOUN
admet-2753	90	17	permeability	permeability	NOUN
admet-2753	90	18	of	of	ADP
admet-2753	90	19	the	the	DET
admet-2753	90	20	drug	drug	NOUN
admet-2753	90	21	molecules	molecule	NOUN
admet-2753	90	22	for	for	ADP
admet-2753	90	23	lipophilic	lipophilic	ADJ
admet-2753	90	24	and	and	CCONJ
admet-2753	90	25	size	size	NOUN
admet-2753	90	26	-	-	PUNCT
admet-2753	90	27	exclusion	exclusion	NOUN
admet-2753	90	28	membranes	membrane	NOUN
admet-2753	90	29	,	,	PUNCT
admet-2753	90	30	and	and	CCONJ
admet-2753	90	31	puwl	puwl	PROPN
admet-2753	90	32	is	be	AUX
admet-2753	90	33	the	the	DET
admet-2753	90	34	uwl	uwl	NOUN
admet-2753	90	35	permeability	permeability	NOUN
admet-2753	90	36	of	of	ADP
admet-2753	90	37	the	the	DET
admet-2753	90	38	drug	drug	NOUN
admet-2753	90	39	.	.	PUNCT
admet-2753	91	1	since	since	SCONJ
admet-2753	91	2	the	the	DET
admet-2753	91	3	different	different	ADJ
admet-2753	91	4	membrane	membrane	NOUN
admet-2753	91	5	types	type	NOUN
admet-2753	91	6	were	be	AUX
admet-2753	91	7	placed	place	VERB
admet-2753	91	8	in	in	ADP
admet-2753	91	9	the	the	DET
admet-2753	91	10	same	same	ADJ
admet-2753	91	11	side	side	NOUN
admet-2753	91	12	-	-	PUNCT
admet-2753	91	13	by	by	ADP
admet-2753	91	14	-	-	PUNCT
admet-2753	91	15	side	side	NOUN
admet-2753	91	16	diffusion	diffusion	NOUN
admet-2753	91	17	cell	cell	NOUN
admet-2753	91	18	,	,	PUNCT
admet-2753	91	19	the	the	DET
admet-2753	91	20	puwl	puwl	NOUN
admet-2753	91	21	and	and	CCONJ
admet-2753	91	22	the	the	DET
admet-2753	91	23	thickness	thickness	NOUN
admet-2753	91	24	of	of	ADP
admet-2753	91	25	the	the	DET
admet-2753	91	26	uwl	uwl	NOUN
admet-2753	91	27	(	(	PUNCT
admet-2753	91	28	huwl	huwl	NOUN
admet-2753	91	29	)	)	PUNCT
admet-2753	91	30	are	be	AUX
admet-2753	91	31	the	the	DET
admet-2753	91	32	same	same	ADJ
admet-2753	91	33	for	for	ADP
admet-2753	91	34	all	all	DET
admet-2753	91	35	types	type	NOUN
admet-2753	91	36	of	of	ADP
admet-2753	91	37	membrane	membrane	NOUN
admet-2753	91	38	when	when	SCONJ
admet-2753	91	39	using	use	VERB
admet-2753	91	40	the	the	DET
admet-2753	91	41	donor	donor	NOUN
admet-2753	91	42	and	and	CCONJ
admet-2753	91	43	acceptor	acceptor	NOUN
admet-2753	91	44	media	medium	NOUN
admet-2753	91	45	,	,	PUNCT
admet-2753	91	46	and	and	CCONJ
admet-2753	91	47	the	the	DET
admet-2753	91	48	same	same	ADJ
admet-2753	91	49	stirring	stirring	NOUN
admet-2753	91	50	speed	speed	NOUN
admet-2753	91	51	.	.	PUNCT
admet-2753	92	1	the	the	DET
admet-2753	92	2	unbound	unbound	NOUN
admet-2753	92	3	fraction	fraction	NOUN
admet-2753	92	4	(	(	PUNCT
admet-2753	92	5	fu	fu	NOUN
admet-2753	92	6	)	)	PUNCT
admet-2753	92	7	can	can	AUX
admet-2753	92	8	be	be	AUX
admet-2753	92	9	calculated	calculate	VERB
admet-2753	92	10	as	as	ADP
admet-2753	92	11	the	the	DET
admet-2753	92	12	equilibrium	equilibrium	NOUN
admet-2753	92	13	solubility	solubility	NOUN
admet-2753	92	14	of	of	ADP
admet-2753	92	15	the	the	DET
admet-2753	92	16	plain	plain	ADJ
admet-2753	92	17	buffer	buffer	NOUN
admet-2753	92	18	(	(	PUNCT
admet-2753	92	19	sbuffer	sbuffer	NOUN
admet-2753	92	20	)	)	PUNCT
admet-2753	92	21	divided	divide	VERB
admet-2753	92	22	by	by	ADP
admet-2753	92	23	the	the	DET
admet-2753	92	24	solubility	solubility	NOUN
admet-2753	92	25	measured	measure	VERB
admet-2753	92	26	in	in	ADP
admet-2753	92	27	the	the	DET
admet-2753	92	28	presence	presence	NOUN
admet-2753	92	29	of	of	ADP
admet-2753	92	30	hp	hp	PROPN
admet-2753	92	31	-	-	PUNCT
admet-2753	92	32	β	β	NOUN
admet-2753	92	33	-	-	NOUN
admet-2753	92	34	cd	cd	PROPN
admet-2753	92	35	(	(	PUNCT
admet-2753	92	36	scd	scd	PROPN
admet-2753	92	37	)	)	PUNCT
admet-2753	92	38	(	(	PUNCT
admet-2753	92	39	equation	equation	NOUN
admet-2753	92	40	(	(	PUNCT
admet-2753	92	41	4	4	NUM
admet-2753	92	42	)	)	PUNCT
admet-2753	92	43	)	)	PUNCT
admet-2753	92	44	.	.	PUNCT
admet-2753	93	1	buffer	buffer	VERB
admet-2753	93	2	u	u	PRON
admet-2753	93	3	cd	cd	PROPN
admet-2753	93	4	s	s	PROPN
admet-2753	93	5	f	f	PROPN
admet-2753	93	6	s	s	PART
admet-2753	93	7	=	=	X
admet-2753	93	8	(	(	PUNCT
admet-2753	93	9	4	4	NUM
admet-2753	93	10	)	)	PUNCT
admet-2753	93	11	in	in	ADP
admet-2753	93	12	this	this	DET
admet-2753	93	13	case	case	NOUN
admet-2753	93	14	,	,	PUNCT
admet-2753	93	15	e	e	X
admet-2753	93	16	uwl	uwl	AUX
admet-2753	93	17	u	u	NOUN
admet-2753	93	18	membrane	membrane	NOUN
admet-2753	93	19	,	,	PUNCT
admet-2753	93	20	 	 	SPACE
admet-2753	93	21	lipophilic	lipophilic	NOUN
admet-2753	93	22	,	,	PUNCT
admet-2753	93	23	u	u	NOUN
admet-2753	93	24	1	1	NUM
admet-2753	93	25	1	1	NUM
admet-2753	93	26	1	1	NUM
admet-2753	93	27	p	p	NOUN
admet-2753	93	28	p	p	X
admet-2753	93	29	f	f	X
admet-2753	93	30	p	p	X
admet-2753	93	31	=	=	X
admet-2753	93	32	+	+	CCONJ
admet-2753	93	33	(	(	PUNCT
admet-2753	93	34	5	5	NUM
admet-2753	93	35	)	)	PUNCT
admet-2753	93	36	e	e	NOUN
admet-2753	93	37	uwl	uwl	AUX
admet-2753	93	38	u	u	NOUN
admet-2753	93	39	membrane	membrane	NOUN
admet-2753	93	40	,	,	PUNCT
admet-2753	93	41	 	 	SPACE
admet-2753	93	42	size	size	NOUN
admet-2753	93	43	exclusion	exclusion	NOUN
admet-2753	93	44	,	,	PUNCT
admet-2753	93	45	u	u	NOUN
admet-2753	93	46	1	1	NUM
admet-2753	93	47	1	1	NUM
admet-2753	93	48	1	1	NUM
admet-2753	93	49	p	p	NOUN
admet-2753	93	50	p	p	X
admet-2753	93	51	f	f	X
admet-2753	93	52	p	p	NOUN
admet-2753	93	53	−	−	PROPN
admet-2753	94	1	=	=	SYM
admet-2753	94	2	+	+	CCONJ
admet-2753	94	3	(	(	PUNCT
admet-2753	94	4	6	6	NUM
admet-2753	94	5	)	)	PUNCT
admet-2753	94	6	where	where	SCONJ
admet-2753	94	7	pmembrane	pmembrane	NOUN
admet-2753	94	8	,	,	PUNCT
admet-2753	94	9	lipophilic	lipophilic	NOUN
admet-2753	94	10	,	,	PUNCT
admet-2753	94	11	u	u	NOUN
admet-2753	94	12	and	and	CCONJ
admet-2753	94	13	pmembrane	pmembrane	NOUN
admet-2753	94	14	,	,	PUNCT
admet-2753	94	15	size	size	NOUN
admet-2753	94	16	-	-	PUNCT
admet-2753	94	17	exclusion	exclusion	NOUN
admet-2753	94	18	,	,	PUNCT
admet-2753	94	19	u	u	NOUN
admet-2753	94	20	are	be	AUX
admet-2753	94	21	the	the	DET
admet-2753	94	22	permeability	permeability	NOUN
admet-2753	94	23	of	of	ADP
admet-2753	94	24	unbound	unbound	NOUN
admet-2753	94	25	drug	drug	NOUN
admet-2753	94	26	molecules	molecule	NOUN
admet-2753	94	27	for	for	ADP
admet-2753	94	28	pampa	pampa	NOUN
admet-2753	94	29	and	and	CCONJ
admet-2753	94	30	size	size	NOUN
admet-2753	94	31	-	-	PUNCT
admet-2753	94	32	exclusion	exclusion	NOUN
admet-2753	94	33	membrane	membrane	NOUN
admet-2753	94	34	,	,	PUNCT
admet-2753	94	35	respectively	respectively	ADV
admet-2753	94	36	.	.	PUNCT
admet-2753	95	1	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	95	2	p.	p.	PROPN
admet-2753	95	3	tőzsér	tőzsér	PROPN
admet-2753	95	4	et	et	PROPN
admet-2753	95	5	al	al	PROPN
admet-2753	95	6	.	.	PROPN
admet-2753	95	7	admet	admet	PROPN
admet-2753	95	8	&	&	CCONJ
admet-2753	95	9	dmpk	dmpk	PROPN
admet-2753	95	10	13(4	13(4	NUM
admet-2753	95	11	)	)	PUNCT
admet-2753	95	12	(	(	PUNCT
admet-2753	95	13	2025	2025	NUM
admet-2753	95	14	)	)	PUNCT
admet-2753	95	15	2753	2753	NUM
admet-2753	95	16	6	6	NUM
admet-2753	95	17	pmembrane	pmembrane	NOUN
admet-2753	95	18	,	,	PUNCT
admet-2753	95	19	lipophilic	lipophilic	NOUN
admet-2753	95	20	,	,	PUNCT
admet-2753	95	21	u	u	NOUN
admet-2753	95	22	at	at	ADP
admet-2753	95	23	each	each	DET
admet-2753	95	24	ph	ph	NOUN
admet-2753	95	25	can	can	AUX
admet-2753	95	26	be	be	AUX
admet-2753	95	27	calculated	calculate	VERB
admet-2753	95	28	as	as	ADP
admet-2753	95	29	equation	equation	NOUN
admet-2753	95	30	(	(	PUNCT
admet-2753	95	31	7	7	NUM
admet-2753	95	32	):	):	PUNCT
admet-2753	95	33	pmembrane	pmembrane	NOUN
admet-2753	95	34	,	,	PUNCT
admet-2753	95	35	lipophilic	lipophilic	NOUN
admet-2753	95	36	,	,	PUNCT
admet-2753	95	37	u	u	NOUN
admet-2753	95	38	=	=	SYM
admet-2753	95	39	f0pmembrane	f0pmembrane	PROPN
admet-2753	95	40	,	,	PUNCT
admet-2753	95	41	lipophilic	lipophilic	NOUN
admet-2753	95	42	,	,	PUNCT
admet-2753	95	43	u	u	NOUN
admet-2753	95	44	,	,	PUNCT
admet-2753	95	45	0	0	NUM
admet-2753	95	46	(	(	PUNCT
admet-2753	95	47	7	7	NUM
admet-2753	95	48	)	)	PUNCT
admet-2753	95	49	membrane	membrane	NOUN
admet-2753	95	50	permeability	permeability	NOUN
admet-2753	95	51	in	in	ADP
admet-2753	95	52	the	the	DET
admet-2753	95	53	presence	presence	NOUN
admet-2753	95	54	of	of	ADP
admet-2753	95	55	hp	hp	PROPN
admet-2753	95	56	-	-	PUNCT
admet-2753	95	57	β	β	NOUN
admet-2753	95	58	-	-	NOUN
admet-2753	95	59	cd	cd	ADJ
admet-2753	95	60	(	(	PUNCT
admet-2753	95	61	pmembrane	pmembrane	NOUN
admet-2753	95	62	,	,	PUNCT
admet-2753	95	63	lipophilic	lipophilic	NOUN
admet-2753	95	64	)	)	PUNCT
admet-2753	95	65	can	can	AUX
admet-2753	95	66	be	be	AUX
admet-2753	95	67	calculated	calculate	VERB
admet-2753	95	68	considering	consider	VERB
admet-2753	95	69	the	the	DET
admet-2753	95	70	free	free	ADJ
admet-2753	95	71	fraction	fraction	NOUN
admet-2753	95	72	of	of	ADP
admet-2753	95	73	the	the	DET
admet-2753	95	74	drug	drug	NOUN
admet-2753	95	75	(	(	PUNCT
admet-2753	95	76	equation	equation	NOUN
admet-2753	95	77	(	(	PUNCT
admet-2753	95	78	8)	8)	NUM
admet-2753	95	79	):	):	PUNCT
admet-2753	95	80	pmembrane	pmembrane	NOUN
admet-2753	95	81	,	,	PUNCT
admet-2753	95	82	lipophilic	lipophilic	ADJ
admet-2753	95	83	=	=	SYM
admet-2753	95	84	fupmembrane	fupmembrane	NOUN
admet-2753	95	85	,	,	PUNCT
admet-2753	95	86	lipophilic	lipophilic	NOUN
admet-2753	95	87	,	,	PUNCT
admet-2753	96	1	u	u	NOUN
admet-2753	96	2	=	=	PROPN
admet-2753	96	3	=	=	SYM
admet-2753	96	4	fuf0pmembrane	fuf0pmembrane	PROPN
admet-2753	96	5	,	,	PUNCT
admet-2753	96	6	lipophilic	lipophilic	ADJ
admet-2753	96	7	,	,	PUNCT
admet-2753	96	8	u	u	NOUN
admet-2753	96	9	,	,	PUNCT
admet-2753	96	10	0	0	NUM
admet-2753	96	11	(	(	PUNCT
admet-2753	96	12	8)	8)	NUM
admet-2753	96	13	where	where	SCONJ
admet-2753	96	14	f0	f0	PROPN
admet-2753	96	15	is	be	AUX
admet-2753	96	16	the	the	DET
admet-2753	96	17	unionized	unionized	ADJ
admet-2753	96	18	fraction	fraction	NOUN
admet-2753	96	19	of	of	ADP
admet-2753	96	20	a	a	DET
admet-2753	96	21	drug	drug	NOUN
admet-2753	96	22	at	at	ADP
admet-2753	96	23	a	a	DET
admet-2753	96	24	certain	certain	ADJ
admet-2753	96	25	ph	ph	NOUN
admet-2753	96	26	(	(	PUNCT
admet-2753	96	27	see	see	VERB
admet-2753	96	28	table	table	NOUN
admet-2753	96	29	1	1	NUM
admet-2753	96	30	)	)	PUNCT
admet-2753	96	31	,	,	PUNCT
admet-2753	96	32	and	and	CCONJ
admet-2753	96	33	pmembrane	pmembrane	NOUN
admet-2753	96	34	,	,	PUNCT
admet-2753	96	35	lipophilic	lipophilic	NOUN
admet-2753	96	36	,	,	PUNCT
admet-2753	96	37	u	u	PROPN
admet-2753	96	38	is	be	AUX
admet-2753	96	39	the	the	DET
admet-2753	96	40	permeability	permeability	NOUN
admet-2753	96	41	of	of	ADP
admet-2753	96	42	unbound	unbound	NOUN
admet-2753	96	43	and	and	CCONJ
admet-2753	96	44	unionized	unionized	ADJ
admet-2753	96	45	drug	drug	NOUN
admet-2753	96	46	molecules	molecule	NOUN
admet-2753	96	47	.	.	PUNCT
admet-2753	97	1	puwl	puwl	PROPN
admet-2753	97	2	at	at	ADP
admet-2753	97	3	each	each	DET
admet-2753	97	4	ph	ph	NOUN
admet-2753	97	5	and	and	CCONJ
admet-2753	97	6	stirring	stirring	NOUN
admet-2753	97	7	speed	speed	NOUN
admet-2753	97	8	can	can	AUX
admet-2753	97	9	be	be	AUX
admet-2753	97	10	calculated	calculate	VERB
admet-2753	97	11	as	as	ADP
admet-2753	97	12	equation	equation	NOUN
admet-2753	97	13	(	(	PUNCT
admet-2753	97	14	9	9	NUM
admet-2753	97	15	)	)	PUNCT
admet-2753	97	16	in	in	ADP
admet-2753	97	17	the	the	DET
admet-2753	97	18	case	case	NOUN
admet-2753	97	19	of	of	ADP
admet-2753	97	20	pure	pure	ADJ
admet-2753	97	21	buffer	buffer	NOUN
admet-2753	97	22	and	and	CCONJ
admet-2753	97	23	equation	equation	NOUN
admet-2753	97	24	(	(	PUNCT
admet-2753	97	25	10	10	NUM
admet-2753	97	26	)	)	PUNCT
admet-2753	97	27	in	in	ADP
admet-2753	97	28	the	the	DET
admet-2753	97	29	presence	presence	NOUN
admet-2753	97	30	of	of	ADP
admet-2753	97	31	hp	hp	PROPN
admet-2753	97	32	-	-	PUNCT
admet-2753	97	33	β	β	NOUN
admet-2753	97	34	-	-	NOUN
admet-2753	97	35	cd	cd	ADJ
admet-2753	97	36	:	:	PUNCT
admet-2753	97	37	uwl	uwl	PROPN
admet-2753	97	38	,	,	PUNCT
admet-2753	97	39	mono	mono	PROPN
admet-2753	97	40	uwl	uwl	PROPN
admet-2753	97	41	,	,	PUNCT
admet-2753	97	42	 	 	SPACE
admet-2753	97	43	mono	mono	PROPN
admet-2753	97	44	uwl	uwl	PROPN
admet-2753	97	45	,	,	PUNCT
admet-2753	97	46	mono	mono	PROPN
admet-2753	98	1	d	d	X
admet-2753	98	2	p	p	NOUN
admet-2753	98	3	h	h	NOUN
admet-2753	98	4	=	=	PUNCT
admet-2753	98	5	(	(	PUNCT
admet-2753	98	6	9	9	X
admet-2753	98	7	)	)	PUNCT
admet-2753	98	8	uwl	uwl	X
admet-2753	98	9	uwl	uwl	ADV
admet-2753	98	10	uwl	uwl	AUX
admet-2753	99	1	d	d	NOUN
admet-2753	99	2	p	p	NOUN
admet-2753	99	3	h	h	NOUN
admet-2753	99	4	=	=	SYM
admet-2753	99	5	(	(	PUNCT
admet-2753	99	6	10	10	NUM
admet-2753	99	7	)	)	PUNCT
admet-2753	99	8	where	where	SCONJ
admet-2753	99	9	duwl	duwl	NOUN
admet-2753	99	10	is	be	AUX
admet-2753	99	11	the	the	DET
admet-2753	99	12	apparent	apparent	ADJ
admet-2753	99	13	diffusion	diffusion	NOUN
admet-2753	99	14	coefficient	coefficient	NOUN
admet-2753	99	15	of	of	ADP
admet-2753	99	16	the	the	DET
admet-2753	99	17	drug	drug	NOUN
admet-2753	99	18	through	through	ADP
admet-2753	99	19	the	the	DET
admet-2753	99	20	unstirred	unstirred	ADJ
admet-2753	99	21	water	water	NOUN
admet-2753	99	22	layer	layer	NOUN
admet-2753	99	23	in	in	ADP
admet-2753	99	24	the	the	DET
admet-2753	99	25	presence	presence	NOUN
admet-2753	99	26	of	of	ADP
admet-2753	99	27	hp	hp	PROPN
admet-2753	99	28	-	-	PUNCT
admet-2753	99	29	β	β	NOUN
admet-2753	99	30	-	-	NOUN
admet-2753	99	31	cd	cd	NOUN
admet-2753	99	32	and	and	CCONJ
admet-2753	99	33	huwl	huwl	NOUN
admet-2753	99	34	is	be	AUX
admet-2753	99	35	the	the	DET
admet-2753	99	36	apparent	apparent	ADJ
admet-2753	99	37	unstirred	unstirred	ADJ
admet-2753	99	38	water	water	NOUN
admet-2753	99	39	layer	layer	NOUN
admet-2753	99	40	thickness	thickness	NOUN
admet-2753	99	41	in	in	ADP
admet-2753	99	42	the	the	DET
admet-2753	99	43	presence	presence	NOUN
admet-2753	99	44	of	of	ADP
admet-2753	99	45	hp	hp	PROPN
admet-2753	99	46	-	-	PUNCT
admet-2753	99	47	β	β	NOUN
admet-2753	99	48	-	-	NOUN
admet-2753	99	49	cd	cd	NOUN
admet-2753	99	50	.	.	PUNCT
admet-2753	100	1	the	the	DET
admet-2753	100	2	diffusion	diffusion	NOUN
admet-2753	100	3	coefficient	coefficient	NOUN
admet-2753	100	4	of	of	ADP
admet-2753	100	5	the	the	DET
admet-2753	100	6	monomer	monomer	NOUN
admet-2753	100	7	(	(	PUNCT
admet-2753	100	8	duwl	duwl	PROPN
admet-2753	100	9	,	,	PUNCT
admet-2753	100	10	mono	mono	PROPN
admet-2753	100	11	)	)	PUNCT
admet-2753	100	12	and	and	CCONJ
admet-2753	100	13	the	the	DET
admet-2753	100	14	drug	drug	NOUN
admet-2753	100	15	-	-	PUNCT
admet-2753	100	16	hp	hp	NOUN
admet-2753	100	17	-	-	PUNCT
admet-2753	100	18	β	β	NOUN
admet-2753	100	19	-	-	ADJ
admet-2753	100	20	cd	cd	ADJ
admet-2753	100	21	complex	complex	NOUN
admet-2753	100	22	(	(	PUNCT
admet-2753	100	23	duwl	duwl	NOUN
admet-2753	100	24	,	,	PUNCT
admet-2753	100	25	complex	complex	NOUN
admet-2753	100	26	)	)	PUNCT
admet-2753	100	27	was	be	AUX
admet-2753	100	28	calculated	calculate	VERB
admet-2753	100	29	at	at	ADP
admet-2753	100	30	37	37	NUM
admet-2753	100	31	°	°	ADP
admet-2753	100	32	c	c	NOUN
admet-2753	100	33	using	use	VERB
admet-2753	100	34	equation	equation	NOUN
admet-2753	100	35	(	(	PUNCT
admet-2753	100	36	11	11	NUM
admet-2753	100	37	)	)	PUNCT
admet-2753	101	1	[	[	X
admet-2753	101	2	9	9	NUM
admet-2753	101	3	]	]	SYM
admet-2753	101	4	:	:	PUNCT
admet-2753	101	5	d	d	X
admet-2753	101	6	=	=	SYM
admet-2753	101	7	9.910	9.910	NUM
admet-2753	101	8	-	-	PUNCT
admet-2753	101	9	5	5	NUM
admet-2753	101	10	mw-0.453	mw-0.453	NOUN
admet-2753	101	11	(	(	PUNCT
admet-2753	101	12	11	11	NUM
admet-2753	101	13	)	)	PUNCT
admet-2753	101	14	where	where	SCONJ
admet-2753	101	15	mw	mw	PROPN
admet-2753	101	16	is	be	AUX
admet-2753	101	17	the	the	DET
admet-2753	101	18	molecular	molecular	ADJ
admet-2753	101	19	weight	weight	NOUN
admet-2753	101	20	of	of	ADP
admet-2753	101	21	the	the	DET
admet-2753	101	22	monomer	monomer	NOUN
admet-2753	101	23	or	or	CCONJ
admet-2753	101	24	the	the	DET
admet-2753	101	25	drug	drug	NOUN
admet-2753	101	26	-	-	PUNCT
admet-2753	101	27	hp	hp	NOUN
admet-2753	101	28	-	-	PUNCT
admet-2753	101	29	β	β	NOUN
admet-2753	101	30	-	-	ADJ
admet-2753	101	31	cd	cd	ADJ
admet-2753	101	32	complex	complex	NOUN
admet-2753	101	33	.	.	PUNCT
admet-2753	102	1	the	the	DET
admet-2753	102	2	apparent	apparent	ADJ
admet-2753	102	3	diffusion	diffusion	NOUN
admet-2753	102	4	coefficient	coefficient	NOUN
admet-2753	102	5	of	of	ADP
admet-2753	102	6	the	the	DET
admet-2753	102	7	drug	drug	NOUN
admet-2753	102	8	through	through	ADP
admet-2753	102	9	the	the	DET
admet-2753	102	10	unstirred	unstirred	ADJ
admet-2753	102	11	water	water	NOUN
admet-2753	102	12	layer	layer	NOUN
admet-2753	102	13	in	in	ADP
admet-2753	102	14	the	the	DET
admet-2753	102	15	presence	presence	NOUN
admet-2753	102	16	of	of	ADP
admet-2753	102	17	hp	hp	PROPN
admet-2753	102	18	-	-	PUNCT
admet-2753	102	19	βcd	βcd	NOUN
admet-2753	102	20	can	can	AUX
admet-2753	102	21	be	be	AUX
admet-2753	102	22	calculated	calculate	VERB
admet-2753	102	23	from	from	ADP
admet-2753	102	24	the	the	DET
admet-2753	102	25	diffusion	diffusion	NOUN
admet-2753	102	26	coefficient	coefficient	NOUN
admet-2753	102	27	of	of	ADP
admet-2753	102	28	the	the	DET
admet-2753	102	29	monomer	monomer	NOUN
admet-2753	102	30	and	and	CCONJ
admet-2753	102	31	the	the	DET
admet-2753	102	32	complex	complex	ADJ
admet-2753	102	33	following	follow	VERB
admet-2753	102	34	equation	equation	NOUN
admet-2753	102	35	(	(	PUNCT
admet-2753	102	36	12	12	NUM
admet-2753	102	37	):	):	PUNCT
admet-2753	102	38	duwl	duwl	NOUN
admet-2753	102	39	=	=	SYM
admet-2753	102	40	fuduwl	fuduwl	PROPN
admet-2753	102	41	.	.	PUNCT
admet-2753	103	1	mono	mono	PROPN
admet-2753	103	2	+	+	CCONJ
admet-2753	103	3	(	(	PUNCT
admet-2753	103	4	1	1	NUM
admet-2753	103	5	fu)duwl	fu)duwl	ADV
admet-2753	103	6	.	.	PUNCT
admet-2753	104	1	complex	complex	ADJ
admet-2753	104	2	(	(	PUNCT
admet-2753	104	3	12	12	NUM
admet-2753	104	4	)	)	PUNCT
admet-2753	104	5	phase	phase	NOUN
admet-2753	104	6	solubility	solubility	NOUN
admet-2753	104	7	study	study	NOUN
admet-2753	104	8	of	of	ADP
admet-2753	104	9	car	car	NOUN
admet-2753	104	10	-	-	PUNCT
admet-2753	104	11	hp	hp	NOUN
admet-2753	104	12	-	-	PUNCT
admet-2753	104	13	β	β	NOUN
admet-2753	104	14	-	-	ADJ
admet-2753	104	15	cd	cd	ADJ
admet-2753	104	16	complex	complex	NOUN
admet-2753	104	17	for	for	ADP
admet-2753	104	18	the	the	DET
admet-2753	104	19	investigation	investigation	NOUN
admet-2753	104	20	of	of	ADP
admet-2753	104	21	the	the	DET
admet-2753	104	22	complexation	complexation	NOUN
admet-2753	104	23	,	,	PUNCT
admet-2753	104	24	an	an	DET
admet-2753	104	25	excess	excess	ADJ
admet-2753	104	26	amount	amount	NOUN
admet-2753	104	27	of	of	ADP
admet-2753	104	28	crystalline	crystalline	ADJ
admet-2753	104	29	car	car	NOUN
admet-2753	104	30	(	(	PUNCT
admet-2753	104	31	5	5	NUM
admet-2753	104	32	mg	mg	NOUN
admet-2753	104	33	form	form	NOUN
admet-2753	104	34	i	i	PRON
admet-2753	104	35	or	or	CCONJ
admet-2753	104	36	form	form	PROPN
admet-2753	104	37	ii	ii	PROPN
admet-2753	104	38	)	)	PUNCT
admet-2753	104	39	was	be	AUX
admet-2753	104	40	added	add	VERB
admet-2753	104	41	to	to	ADP
admet-2753	104	42	10	10	NUM
admet-2753	104	43	ml	ml	NOUN
admet-2753	104	44	of	of	ADP
admet-2753	104	45	ph	ph	PROPN
admet-2753	104	46	10	10	NUM
admet-2753	104	47	prisma	prisma	NOUN
admet-2753	104	48	buffer	buffer	NOUN
admet-2753	104	49	containing	contain	VERB
admet-2753	104	50	0	0	NUM
admet-2753	104	51	,	,	PUNCT
admet-2753	104	52	2.5	2.5	NUM
admet-2753	104	53	,	,	PUNCT
admet-2753	104	54	5	5	NUM
admet-2753	104	55	,	,	PUNCT
admet-2753	104	56	10	10	NUM
admet-2753	104	57	,	,	PUNCT
admet-2753	104	58	15	15	NUM
admet-2753	104	59	,	,	PUNCT
admet-2753	104	60	20	20	NUM
admet-2753	104	61	mg	mg	NOUN
admet-2753	104	62	ml-1	ml-1	PRON
admet-2753	104	63	hp	hp	PROPN
admet-2753	104	64	-	-	PUNCT
admet-2753	104	65	β	β	NOUN
admet-2753	104	66	-	-	NOUN
admet-2753	104	67	cd	cd	NOUN
admet-2753	104	68	,	,	PUNCT
admet-2753	104	69	respectively	respectively	ADV
admet-2753	104	70	.	.	PUNCT
admet-2753	105	1	the	the	DET
admet-2753	105	2	resulting	result	VERB
admet-2753	105	3	solutions	solution	NOUN
admet-2753	105	4	were	be	AUX
admet-2753	105	5	stirred	stir	VERB
admet-2753	105	6	at	at	ADP
admet-2753	105	7	250	250	NUM
admet-2753	105	8	rpm	rpm	NOUN
admet-2753	105	9	for	for	ADP
admet-2753	105	10	6	6	NUM
admet-2753	105	11	h	h	NOUN
admet-2753	105	12	and	and	CCONJ
admet-2753	105	13	then	then	ADV
admet-2753	105	14	sedimented	sediment	VERB
admet-2753	105	15	for	for	ADP
admet-2753	105	16	18	18	NUM
admet-2753	105	17	h	h	NOUN
admet-2753	105	18	as	as	SCONJ
admet-2753	105	19	described	describe	VERB
admet-2753	105	20	in	in	ADP
admet-2753	105	21	the	the	DET
admet-2753	105	22	equilibrium	equilibrium	NOUN
admet-2753	105	23	solubility	solubility	NOUN
admet-2753	105	24	measurement	measurement	NOUN
admet-2753	105	25	protocol	protocol	NOUN
admet-2753	106	1	[	[	X
admet-2753	106	2	47,48	47,48	NUM
admet-2753	106	3	]	]	X
admet-2753	106	4	.	.	PUNCT
admet-2753	107	1	the	the	DET
admet-2753	107	2	samples	sample	NOUN
admet-2753	107	3	were	be	AUX
admet-2753	107	4	continuously	continuously	ADV
admet-2753	107	5	thermostated	thermostat	VERB
admet-2753	107	6	at	at	ADP
admet-2753	107	7	37	37	NUM
admet-2753	107	8	°	°	NOUN
admet-2753	107	9	c	c	NOUN
admet-2753	107	10	.	.	PUNCT
admet-2753	108	1	after	after	ADP
admet-2753	108	2	sedimentation	sedimentation	NOUN
admet-2753	108	3	,	,	PUNCT
admet-2753	108	4	the	the	DET
admet-2753	108	5	concentration	concentration	NOUN
admet-2753	108	6	of	of	ADP
admet-2753	108	7	car	car	NOUN
admet-2753	108	8	was	be	AUX
admet-2753	108	9	measured	measure	VERB
admet-2753	108	10	using	use	VERB
admet-2753	108	11	a	a	DET
admet-2753	108	12	uv	uv	NOUN
admet-2753	108	13	probe	probe	NOUN
admet-2753	108	14	connected	connect	VERB
admet-2753	108	15	to	to	PART
admet-2753	108	16	rainbow	rainbow	VERB
admet-2753	108	17	μdiss	μdiss	ADJ
admet-2753	108	18	profiler	profiler	NOUN
admet-2753	108	19	(	(	PUNCT
admet-2753	108	20	pion	pion	PROPN
admet-2753	108	21	inc	inc	PROPN
admet-2753	108	22	,	,	PUNCT
admet-2753	108	23	billerica	billerica	PROPN
admet-2753	108	24	,	,	PUNCT
admet-2753	108	25	ma	ma	PROPN
admet-2753	108	26	,	,	PUNCT
admet-2753	108	27	usa	usa	PROPN
admet-2753	108	28	)	)	PUNCT
admet-2753	108	29	at	at	ADP
admet-2753	108	30	292	292	NUM
admet-2753	108	31	to	to	PART
admet-2753	108	32	300	300	NUM
admet-2753	108	33	nm	nm	NOUN
admet-2753	108	34	with	with	ADP
admet-2753	108	35	the	the	DET
admet-2753	108	36	second	second	ADJ
admet-2753	108	37	derivative	derivative	ADJ
admet-2753	108	38	method	method	NOUN
admet-2753	108	39	.	.	PUNCT
admet-2753	109	1	in	in	ADP
admet-2753	109	2	all	all	DET
admet-2753	109	3	cases	case	NOUN
admet-2753	109	4	,	,	PUNCT
admet-2753	109	5	the	the	DET
admet-2753	109	6	excess	excess	ADJ
admet-2753	109	7	solids	solid	NOUN
admet-2753	109	8	from	from	ADP
admet-2753	109	9	the	the	DET
admet-2753	109	10	solutions	solution	NOUN
admet-2753	109	11	were	be	AUX
admet-2753	109	12	sampled	sample	VERB
admet-2753	109	13	and	and	CCONJ
admet-2753	109	14	subjected	subject	VERB
admet-2753	109	15	to	to	ADP
admet-2753	109	16	differential	differential	ADJ
admet-2753	109	17	scanning	scanning	NOUN
admet-2753	109	18	calorimetry	calorimetry	NOUN
admet-2753	109	19	(	(	PUNCT
admet-2753	109	20	dsc	dsc	NOUN
admet-2753	109	21	)	)	PUNCT
admet-2753	109	22	with	with	ADP
admet-2753	109	23	mettler	mettler	PROPN
admet-2753	109	24	toledodsc	toledodsc	PROPN
admet-2753	109	25	3	3	NUM
admet-2753	109	26	+	+	CCONJ
admet-2753	109	27	(	(	PUNCT
admet-2753	109	28	stare	stare	ADJ
admet-2753	109	29	evaluation	evaluation	NOUN
admet-2753	109	30	software	software	NOUN
admet-2753	110	1	[	[	X
admet-2753	110	2	49	49	NUM
admet-2753	110	3	]	]	PUNCT
admet-2753	110	4	,	,	PUNCT
admet-2753	110	5	25	25	NUM
admet-2753	110	6	to	to	PART
admet-2753	110	7	150	150	NUM
admet-2753	110	8	°	°	NOUN
admet-2753	110	9	c	c	NOUN
admet-2753	110	10	,	,	PUNCT
admet-2753	110	11	10	10	NUM
admet-2753	110	12	°	°	NOUN
admet-2753	110	13	c	c	NOUN
admet-2753	110	14	min-1	min-1	NOUN
admet-2753	110	15	)	)	PUNCT
admet-2753	110	16	and	and	CCONJ
admet-2753	110	17	raman	raman	NOUN
admet-2753	110	18	spectroscopy	spectroscopy	NOUN
admet-2753	110	19	measurements	measurement	NOUN
admet-2753	110	20	with	with	ADP
admet-2753	110	21	perkinelmer	perkinelmer	ADJ
admet-2753	110	22	system	system	NOUN
admet-2753	110	23	2000	2000	NUM
admet-2753	110	24	nir	nir	PROPN
admet-2753	110	25	ft	ft	NOUN
admet-2753	110	26	-	-	PUNCT
admet-2753	110	27	raman	raman	NOUN
admet-2753	110	28	(	(	PUNCT
admet-2753	110	29	spectrum	spectrum	NOUN
admet-2753	110	30	v5	v5	PROPN
admet-2753	110	31	0.1	0.1	NUM
admet-2753	110	32	software	software	NOUN
admet-2753	110	33	[	[	X
admet-2753	110	34	50	50	NUM
admet-2753	110	35	]	]	PUNCT
admet-2753	110	36	,	,	PUNCT
admet-2753	110	37	raman	raman	NOUN
admet-2753	110	38	laser	laser	NOUN
admet-2753	110	39	power	power	NOUN
admet-2753	110	40	:	:	PUNCT
admet-2753	110	41	500	500	NUM
admet-2753	110	42	mw	mw	NOUN
admet-2753	110	43	,	,	PUNCT
admet-2753	110	44	accumulations	accumulation	NOUN
admet-2753	110	45	:	:	PUNCT
admet-2753	110	46	64	64	NUM
admet-2753	110	47	,	,	PUNCT
admet-2753	110	48	resolution	resolution	NOUN
admet-2753	110	49	:	:	PUNCT
admet-2753	110	50	4	4	NUM
admet-2753	110	51	cm-1	cm-1	NOUN
admet-2753	110	52	,	,	PUNCT
admet-2753	110	53	raman	raman	NOUN
admet-2753	110	54	shift	shift	NOUN
admet-2753	110	55	:	:	PUNCT
admet-2753	110	56	3500	3500	NUM
admet-2753	110	57	to	to	PART
admet-2753	110	58	100	100	NUM
admet-2753	110	59	cm-1	cm-1	NOUN
admet-2753	110	60	)	)	PUNCT
admet-2753	110	61	.	.	PUNCT
admet-2753	111	1	membrane	membrane	NOUN
admet-2753	111	2	transport	transport	NOUN
admet-2753	111	3	of	of	ADP
admet-2753	111	4	hp	hp	PROPN
admet-2753	111	5	-	-	PUNCT
admet-2753	111	6	β	β	NOUN
admet-2753	111	7	-	-	NOUN
admet-2753	111	8	cd	cd	NOUN
admet-2753	111	9	with	with	ADP
admet-2753	111	10	µflux	µflux	NOUN
admet-2753	111	11	apparatus	apparatus	NOUN
admet-2753	111	12	(	(	PUNCT
admet-2753	111	13	pion	pion	PROPN
admet-2753	111	14	inc	inc	PROPN
admet-2753	111	15	.	.	PROPN
admet-2753	111	16	,	,	PUNCT
admet-2753	111	17	billerica	billerica	PROPN
admet-2753	111	18	ma	ma	PROPN
admet-2753	111	19	,	,	PUNCT
admet-2753	111	20	usa	usa	PROPN
admet-2753	111	21	)	)	PUNCT
admet-2753	111	22	,	,	PUNCT
admet-2753	111	23	20	20	NUM
admet-2753	111	24	ml	ml	NOUN
admet-2753	111	25	of	of	ADP
admet-2753	111	26	prisma	prisma	NOUN
admet-2753	111	27	buffer	buffer	NOUN
admet-2753	111	28	containing	contain	VERB
admet-2753	111	29	15	15	NUM
admet-2753	111	30	mg	mg	NOUN
admet-2753	111	31	ml-1	ml-1	PRON
admet-2753	111	32	hp	hp	PROPN
admet-2753	111	33	-	-	PUNCT
admet-2753	111	34	βcd	βcd	NUM
admet-2753	111	35	and	and	CCONJ
admet-2753	111	36	50	50	NUM
admet-2753	111	37	μg	μg	PROPN
admet-2753	111	38	ml-1	ml-1	PRON
admet-2753	111	39	car	car	NOUN
admet-2753	111	40	was	be	AUX
admet-2753	111	41	placed	place	VERB
admet-2753	111	42	on	on	ADP
admet-2753	111	43	the	the	DET
admet-2753	111	44	donor	donor	NOUN
admet-2753	111	45	side	side	NOUN
admet-2753	111	46	,	,	PUNCT
admet-2753	111	47	and	and	CCONJ
admet-2753	111	48	20	20	NUM
admet-2753	111	49	ml	ml	NOUN
admet-2753	111	50	of	of	ADP
admet-2753	111	51	pure	pure	ADJ
admet-2753	111	52	prisma	prisma	NOUN
admet-2753	111	53	buffer	buffer	NOUN
admet-2753	111	54	was	be	AUX
admet-2753	111	55	placed	place	VERB
admet-2753	111	56	on	on	ADP
admet-2753	111	57	the	the	DET
admet-2753	111	58	acceptor	acceptor	NOUN
admet-2753	111	59	side	side	NOUN
admet-2753	111	60	.	.	PUNCT
admet-2753	112	1	the	the	DET
admet-2753	112	2	stirring	stir	VERB
admet-2753	112	3	speed	speed	NOUN
admet-2753	112	4	was	be	AUX
admet-2753	112	5	kept	keep	VERB
admet-2753	112	6	at	at	ADP
admet-2753	112	7	250	250	NUM
admet-2753	112	8	rpm	rpm	NOUN
admet-2753	112	9	,	,	PUNCT
admet-2753	112	10	and	and	CCONJ
admet-2753	112	11	the	the	DET
admet-2753	112	12	car	car	NOUN
admet-2753	112	13	concentration	concentration	NOUN
admet-2753	112	14	of	of	ADP
admet-2753	112	15	the	the	DET
admet-2753	112	16	two	two	NUM
admet-2753	112	17	solutions	solution	NOUN
admet-2753	112	18	was	be	AUX
admet-2753	112	19	monitored	monitor	VERB
admet-2753	112	20	at	at	ADP
admet-2753	112	21	37	37	NUM
admet-2753	112	22	°	°	ADP
admet-2753	112	23	c	c	NOUN
admet-2753	112	24	using	use	VERB
admet-2753	112	25	uv	uv	NOUN
admet-2753	112	26	probes	probe	NOUN
admet-2753	112	27	connected	connect	VERB
admet-2753	112	28	to	to	PART
admet-2753	112	29	rainbow	rainbow	VERB
admet-2753	112	30	μdiss	μdiss	ADJ
admet-2753	112	31	profiler	profiler	NOUN
admet-2753	112	32	(	(	PUNCT
admet-2753	112	33	pion	pion	PROPN
admet-2753	112	34	inc	inc	PROPN
admet-2753	112	35	,	,	PUNCT
admet-2753	112	36	billerica	billerica	PROPN
admet-2753	112	37	,	,	PUNCT
admet-2753	112	38	ma	ma	PROPN
admet-2753	112	39	,	,	PUNCT
admet-2753	112	40	usa	usa	PROPN
admet-2753	112	41	)	)	PUNCT
admet-2753	112	42	at	at	ADP
admet-2753	112	43	292	292	NUM
admet-2753	112	44	to	to	PART
admet-2753	112	45	300	300	NUM
admet-2753	112	46	nm	nm	NOUN
admet-2753	112	47	with	with	ADP
admet-2753	112	48	the	the	DET
admet-2753	112	49	second	second	ADJ
admet-2753	112	50	derivative	derivative	ADJ
admet-2753	112	51	method	method	NOUN
admet-2753	112	52	.	.	PUNCT
admet-2753	113	1	the	the	DET
admet-2753	113	2	transport	transport	NOUN
admet-2753	113	3	of	of	ADP
admet-2753	113	4	hp	hp	PROPN
admet-2753	113	5	-	-	PUNCT
admet-2753	113	6	β	β	NOUN
admet-2753	113	7	-	-	NOUN
admet-2753	113	8	cd	cd	NOUN
admet-2753	113	9	across	across	ADP
admet-2753	113	10	different	different	ADJ
admet-2753	113	11	membranes	membrane	NOUN
admet-2753	113	12	(	(	PUNCT
admet-2753	113	13	1	1	NUM
admet-2753	113	14	kda	kda	NOUN
admet-2753	113	15	and	and	CCONJ
admet-2753	113	16	6	6	NUM
admet-2753	113	17	kda	kda	NOUN
admet-2753	113	18	size	size	NOUN
admet-2753	113	19	exclusion	exclusion	NOUN
admet-2753	113	20	membrane	membrane	NOUN
admet-2753	113	21	and	and	CCONJ
admet-2753	113	22	lipophilic	lipophilic	ADJ
admet-2753	113	23	membrane	membrane	NOUN
admet-2753	113	24	)	)	PUNCT
admet-2753	113	25	was	be	AUX
admet-2753	113	26	investigated	investigate	VERB
admet-2753	113	27	using	use	VERB
admet-2753	113	28	the	the	DET
admet-2753	113	29	buvari	buvari	NOUN
admet-2753	113	30	-	-	PUNCT
admet-2753	113	31	barcza	barcza	NOUN
admet-2753	114	1	[	[	X
admet-2753	114	2	51	51	NUM
admet-2753	114	3	]	]	SYM
admet-2753	114	4	method	method	NOUN
admet-2753	114	5	.	.	PUNCT
admet-2753	115	1	for	for	ADP
admet-2753	115	2	this	this	DET
admet-2753	115	3	purpose	purpose	NOUN
admet-2753	115	4	,	,	PUNCT
admet-2753	115	5	cd	cd	PROPN
admet-2753	115	6	concentrations	concentration	NOUN
admet-2753	115	7	were	be	AUX
admet-2753	115	8	measured	measure	VERB
admet-2753	115	9	in	in	ADP
admet-2753	115	10	the	the	DET
admet-2753	115	11	acceptor	acceptor	NOUN
admet-2753	115	12	solution	solution	NOUN
admet-2753	115	13	.	.	PUNCT
admet-2753	116	1	a	a	DET
admet-2753	116	2	phenolphthalein	phenolphthalein	NOUN
admet-2753	116	3	stock	stock	NOUN
admet-2753	116	4	solution	solution	NOUN
admet-2753	116	5	of	of	ADP
admet-2753	116	6	3.75	3.75	NUM
admet-2753	116	7	mm	mm	NOUN
admet-2753	116	8	dissolved	dissolve	VERB
admet-2753	116	9	in	in	ADP
admet-2753	116	10	96	96	NUM
admet-2753	116	11	%	%	NOUN
admet-2753	116	12	by	by	ADP
admet-2753	116	13	volume	volume	NOUN
admet-2753	116	14	ethanol	ethanol	NOUN
admet-2753	116	15	was	be	AUX
admet-2753	116	16	diluted	dilute	VERB
admet-2753	116	17	tenfold	tenfold	ADV
admet-2753	116	18	with	with	ADP
admet-2753	116	19	distilled	distil	VERB
admet-2753	116	20	water	water	NOUN
admet-2753	116	21	,	,	PUNCT
admet-2753	116	22	and	and	CCONJ
admet-2753	116	23	admet	admet	PROPN
admet-2753	116	24	&	&	CCONJ
admet-2753	116	25	dmpk	dmpk	PROPN
admet-2753	116	26	13(4	13(4	NUM
admet-2753	116	27	)	)	PUNCT
admet-2753	116	28	(	(	PUNCT
admet-2753	116	29	2025	2025	NUM
admet-2753	116	30	)	)	PUNCT
admet-2753	116	31	2753	2753	NUM
admet-2753	116	32	comparison	comparison	NOUN
admet-2753	116	33	of	of	ADP
admet-2753	116	34	lipophilic	lipophilic	ADJ
admet-2753	116	35	and	and	CCONJ
admet-2753	116	36	size	size	NOUN
admet-2753	116	37	-	-	PUNCT
admet-2753	116	38	exclusion	exclusion	NOUN
admet-2753	116	39	membranes	membrane	NOUN
admet-2753	116	40	doi	doi	NOUN
admet-2753	116	41	:	:	PUNCT
admet-2753	116	42	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	116	43	7	7	NUM
admet-2753	116	44	a	a	DET
admet-2753	116	45	4	4	NUM
admet-2753	116	46	mm	mm	NOUN
admet-2753	116	47	na2co3	na2co3	ADJ
admet-2753	116	48	solution	solution	NOUN
admet-2753	116	49	was	be	AUX
admet-2753	116	50	prepared	prepare	VERB
admet-2753	116	51	.	.	PUNCT
admet-2753	117	1	in	in	ADP
admet-2753	117	2	a	a	DET
admet-2753	117	3	250	250	NUM
admet-2753	117	4	ml	ml	NOUN
admet-2753	117	5	volumetric	volumetric	ADJ
admet-2753	117	6	flask	flask	NOUN
admet-2753	117	7	,	,	PUNCT
admet-2753	117	8	20	20	NUM
admet-2753	117	9	ml	ml	NOUN
admet-2753	117	10	of	of	ADP
admet-2753	117	11	aqueous	aqueous	ADJ
admet-2753	117	12	phenolphthalein	phenolphthalein	NOUN
admet-2753	117	13	solution	solution	NOUN
admet-2753	117	14	was	be	AUX
admet-2753	117	15	mixed	mix	VERB
admet-2753	117	16	with	with	ADP
admet-2753	117	17	25	25	NUM
admet-2753	117	18	ml	ml	NOUN
admet-2753	117	19	of	of	ADP
admet-2753	117	20	4	4	NUM
admet-2753	117	21	mm	mm	PROPN
admet-2753	117	22	na2co3	na2co3	ADJ
admet-2753	117	23	solution	solution	NOUN
admet-2753	117	24	,	,	PUNCT
admet-2753	117	25	and	and	CCONJ
admet-2753	117	26	the	the	DET
admet-2753	117	27	flask	flask	NOUN
admet-2753	117	28	was	be	AUX
admet-2753	117	29	made	make	VERB
admet-2753	117	30	up	up	ADP
admet-2753	117	31	to	to	ADP
admet-2753	117	32	the	the	DET
admet-2753	117	33	mark	mark	NOUN
admet-2753	117	34	with	with	ADP
admet-2753	117	35	distilled	distil	VERB
admet-2753	117	36	water	water	NOUN
admet-2753	117	37	.	.	PUNCT
admet-2753	118	1	the	the	DET
admet-2753	118	2	ph	ph	NOUN
admet-2753	118	3	of	of	ADP
admet-2753	118	4	the	the	DET
admet-2753	118	5	buvari	buvari	NOUN
admet-2753	118	6	-	-	PUNCT
admet-2753	118	7	barcza	barcza	NOUN
admet-2753	118	8	solution	solution	NOUN
admet-2753	118	9	was	be	AUX
admet-2753	118	10	adjusted	adjust	VERB
admet-2753	118	11	to	to	ADP
admet-2753	118	12	10.5	10.5	NUM
admet-2753	118	13	with	with	ADP
admet-2753	118	14	na2co3	na2co3	PROPN
admet-2753	118	15	.	.	PUNCT
admet-2753	119	1	every	every	DET
admet-2753	119	2	2	2	NUM
admet-2753	119	3	hours	hour	NOUN
admet-2753	119	4	for	for	ADP
admet-2753	119	5	8	8	NUM
admet-2753	119	6	hours	hour	NOUN
admet-2753	119	7	after	after	ADP
admet-2753	119	8	adding	add	VERB
admet-2753	119	9	1000	1000	NUM
admet-2753	119	10	μl	μl	ADP
admet-2753	119	11	of	of	ADP
admet-2753	119	12	acceptor	acceptor	NOUN
admet-2753	119	13	solution	solution	NOUN
admet-2753	119	14	to	to	ADP
admet-2753	119	15	10	10	NUM
admet-2753	119	16	ml	ml	NOUN
admet-2753	119	17	of	of	ADP
admet-2753	119	18	buvari	buvari	NOUN
admet-2753	119	19	-	-	PUNCT
admet-2753	119	20	barcza	barcza	NOUN
admet-2753	119	21	solution	solution	NOUN
admet-2753	119	22	,	,	PUNCT
admet-2753	119	23	the	the	DET
admet-2753	119	24	absorbance	absorbance	NOUN
admet-2753	119	25	of	of	ADP
admet-2753	119	26	the	the	DET
admet-2753	119	27	solution	solution	NOUN
admet-2753	119	28	was	be	AUX
admet-2753	119	29	measured	measure	VERB
admet-2753	119	30	at	at	ADP
admet-2753	119	31	550	550	NUM
admet-2753	119	32	nm	nm	NOUN
admet-2753	119	33	with	with	ADP
admet-2753	119	34	rainbow	rainbow	NOUN
admet-2753	119	35	uv	uv	NOUN
admet-2753	119	36	probes	probe	NOUN
admet-2753	119	37	.	.	PUNCT
admet-2753	120	1	1000	1000	NUM
admet-2753	120	2	μl	μl	ADP
admet-2753	120	3	of	of	ADP
admet-2753	120	4	donor	donor	NOUN
admet-2753	120	5	solution	solution	NOUN
admet-2753	120	6	was	be	AUX
admet-2753	120	7	also	also	ADV
admet-2753	120	8	withdrawn	withdraw	VERB
admet-2753	120	9	every	every	DET
admet-2753	120	10	two	two	NUM
admet-2753	120	11	hours	hour	NOUN
admet-2753	120	12	to	to	PART
admet-2753	120	13	ensure	ensure	VERB
admet-2753	120	14	that	that	SCONJ
admet-2753	120	15	the	the	DET
admet-2753	120	16	same	same	ADJ
admet-2753	120	17	amount	amount	NOUN
admet-2753	120	18	of	of	ADP
admet-2753	120	19	fluid	fluid	NOUN
admet-2753	120	20	was	be	AUX
admet-2753	120	21	in	in	ADP
admet-2753	120	22	the	the	DET
admet-2753	120	23	μflux	μflux	NOUN
admet-2753	120	24	apparatus	apparatus	NOUN
admet-2753	120	25	on	on	ADP
admet-2753	120	26	the	the	DET
admet-2753	120	27	donor	donor	NOUN
admet-2753	120	28	and	and	CCONJ
admet-2753	120	29	acceptor	acceptor	NOUN
admet-2753	120	30	sides	side	NOUN
admet-2753	120	31	.	.	PUNCT
admet-2753	121	1	in	in	ADP
admet-2753	121	2	vitro	vitro	X
admet-2753	121	3	side	side	NOUN
admet-2753	121	4	-	-	PUNCT
admet-2753	121	5	by	by	ADP
admet-2753	121	6	-	-	PUNCT
admet-2753	121	7	side	side	NOUN
admet-2753	121	8	diffusion	diffusion	NOUN
admet-2753	121	9	cell	cell	NOUN
admet-2753	121	10	assays	assay	NOUN
admet-2753	121	11	to	to	PART
admet-2753	121	12	perform	perform	VERB
admet-2753	121	13	in	in	ADP
admet-2753	121	14	vitro	vitro	X
admet-2753	121	15	side	side	NOUN
admet-2753	121	16	-	-	PUNCT
admet-2753	121	17	by	by	ADP
admet-2753	121	18	-	-	PUNCT
admet-2753	121	19	side	side	NOUN
admet-2753	121	20	diffusion	diffusion	NOUN
admet-2753	121	21	cell	cell	NOUN
admet-2753	121	22	assays	assay	NOUN
admet-2753	121	23	,	,	PUNCT
admet-2753	121	24	the	the	DET
admet-2753	121	25	μflux	μflux	NOUN
admet-2753	121	26	(	(	PUNCT
admet-2753	121	27	pion	pion	PROPN
admet-2753	121	28	inc	inc	PROPN
admet-2753	121	29	.	.	PROPN
admet-2753	121	30	,	,	PUNCT
admet-2753	121	31	billerica	billerica	PROPN
admet-2753	121	32	ma	ma	PROPN
admet-2753	121	33	,	,	PUNCT
admet-2753	121	34	usa	usa	PROPN
admet-2753	121	35	)	)	PUNCT
admet-2753	121	36	apparatus	apparatus	NOUN
admet-2753	121	37	was	be	AUX
admet-2753	121	38	used	use	VERB
admet-2753	121	39	.	.	PUNCT
admet-2753	122	1	artificial	artificial	ADJ
admet-2753	122	2	membranes	membrane	NOUN
admet-2753	122	3	selected	select	VERB
admet-2753	122	4	to	to	PART
admet-2753	122	5	be	be	AUX
admet-2753	122	6	a	a	DET
admet-2753	122	7	size	size	NOUN
admet-2753	122	8	-	-	PUNCT
admet-2753	122	9	exclusion	exclusion	NOUN
admet-2753	122	10	regenerated	regenerate	VERB
admet-2753	122	11	cellulose	cellulose	NOUN
admet-2753	122	12	membrane	membrane	NOUN
admet-2753	122	13	(	(	PUNCT
admet-2753	122	14	mwco	mwco	NOUN
admet-2753	122	15	6	6	NUM
admet-2753	122	16	and	and	CCONJ
admet-2753	122	17	1	1	NUM
admet-2753	122	18	kda	kda	NOUN
admet-2753	122	19	,	,	PUNCT
admet-2753	122	20	1.54	1.54	NUM
admet-2753	122	21	cm2	cm2	NOUN
admet-2753	122	22	)	)	PUNCT
admet-2753	122	23	and	and	CCONJ
admet-2753	122	24	a	a	DET
admet-2753	122	25	lipophilic	lipophilic	ADJ
admet-2753	122	26	membrane	membrane	NOUN
admet-2753	122	27	(	(	PUNCT
admet-2753	122	28	0.45	0.45	NUM
admet-2753	122	29	µm	µm	ADP
admet-2753	122	30	pore	pore	ADJ
admet-2753	122	31	size	size	NOUN
admet-2753	122	32	pvdf	pvdf	PROPN
admet-2753	122	33	sheet	sheet	NOUN
admet-2753	122	34	1.54	1.54	NUM
admet-2753	122	35	cm2	cm2	NOUN
admet-2753	122	36	impregnated	impregnate	VERB
admet-2753	122	37	with	with	ADP
admet-2753	122	38	25	25	NUM
admet-2753	122	39	μl	μl	ADJ
admet-2753	122	40	n	n	CCONJ
admet-2753	122	41	-	-	PUNCT
admet-2753	122	42	dodecane	dodecane	NOUN
admet-2753	122	43	)	)	PUNCT
admet-2753	122	44	.	.	PUNCT
admet-2753	123	1	before	before	ADP
admet-2753	123	2	measurement	measurement	NOUN
admet-2753	123	3	,	,	PUNCT
admet-2753	123	4	the	the	DET
admet-2753	123	5	size	size	NOUN
admet-2753	123	6	-	-	PUNCT
admet-2753	123	7	exclusion	exclusion	NOUN
admet-2753	123	8	membranes	membrane	NOUN
admet-2753	123	9	were	be	AUX
admet-2753	123	10	soaked	soak	VERB
admet-2753	123	11	in	in	ADP
admet-2753	123	12	distilled	distil	VERB
admet-2753	123	13	water	water	NOUN
admet-2753	123	14	overnight	overnight	ADV
admet-2753	123	15	.	.	PUNCT
admet-2753	124	1	measurements	measurement	NOUN
admet-2753	124	2	were	be	AUX
admet-2753	124	3	performed	perform	VERB
admet-2753	124	4	using	use	VERB
admet-2753	124	5	ph	ph	ADJ
admet-2753	124	6	10	10	NUM
admet-2753	124	7	prisma	prisma	NOUN
admet-2753	124	8	buffer	buffer	NOUN
admet-2753	124	9	and	and	CCONJ
admet-2753	124	10	ph	ph	ADJ
admet-2753	124	11	10	10	NUM
admet-2753	124	12	prisma	prisma	NOUN
admet-2753	124	13	buffer	buffer	NOUN
admet-2753	124	14	containing	contain	VERB
admet-2753	124	15	15	15	NUM
admet-2753	124	16	mg	mg	NOUN
admet-2753	124	17	ml-1	ml-1	ADV
admet-2753	125	1	hp	hp	PROPN
admet-2753	125	2	-	-	PUNCT
admet-2753	125	3	β	β	NOUN
admet-2753	125	4	-	-	NOUN
admet-2753	125	5	cd	cd	NOUN
admet-2753	125	6	.	.	PUNCT
admet-2753	126	1	the	the	DET
admet-2753	126	2	measurements	measurement	NOUN
admet-2753	126	3	were	be	AUX
admet-2753	126	4	performed	perform	VERB
admet-2753	126	5	in	in	ADP
admet-2753	126	6	two	two	NUM
admet-2753	126	7	arrangements	arrangement	NOUN
admet-2753	126	8	for	for	ADP
admet-2753	126	9	each	each	DET
admet-2753	126	10	membrane	membrane	NOUN
admet-2753	126	11	type	type	NOUN
admet-2753	126	12	,	,	PUNCT
admet-2753	126	13	as	as	SCONJ
admet-2753	126	14	shown	show	VERB
admet-2753	126	15	in	in	ADP
admet-2753	126	16	table	table	NOUN
admet-2753	126	17	2	2	NUM
admet-2753	126	18	.	.	PUNCT
admet-2753	126	19	table	table	NOUN
admet-2753	126	20	2	2	NUM
admet-2753	126	21	.	.	PUNCT
admet-2753	126	22	in	in	ADP
admet-2753	126	23	vitro	vitro	X
admet-2753	126	24	side	side	NOUN
admet-2753	126	25	-	-	PUNCT
admet-2753	126	26	by	by	ADP
admet-2753	126	27	-	-	PUNCT
admet-2753	126	28	side	side	NOUN
admet-2753	126	29	diffusion	diffusion	NOUN
admet-2753	126	30	cell	cell	NOUN
admet-2753	126	31	setups	setup	NOUN
admet-2753	126	32	donor	donor	VERB
admet-2753	126	33	side	side	NOUN
admet-2753	126	34	acceptor	acceptor	NOUN
admet-2753	126	35	side	side	NOUN
admet-2753	126	36	ph	ph	VERB
admet-2753	126	37	10	10	NUM
admet-2753	126	38	prisma	prisma	NOUN
admet-2753	126	39	buffer	buffer	NOUN
admet-2753	126	40	ph	ph	VERB
admet-2753	126	41	10	10	NUM
admet-2753	126	42	prisma	prisma	NOUN
admet-2753	126	43	buffer	buffer	NOUN
admet-2753	126	44	ph	ph	VERB
admet-2753	126	45	10	10	NUM
admet-2753	126	46	prisma	prisma	NOUN
admet-2753	126	47	buffer	buffer	NOUN
admet-2753	126	48	+	+	CCONJ
admet-2753	126	49	hp	hp	PROPN
admet-2753	126	50	-	-	PUNCT
admet-2753	126	51	β	β	NOUN
admet-2753	126	52	-	-	ADJ
admet-2753	126	53	cd	cd	ADJ
admet-2753	126	54	ph	ph	ADJ
admet-2753	126	55	10	10	NUM
admet-2753	126	56	prisma	prisma	NOUN
admet-2753	126	57	buffer	buffer	NOUN
admet-2753	126	58	18	18	NUM
admet-2753	126	59	ml	ml	NOUN
admet-2753	126	60	of	of	ADP
admet-2753	126	61	the	the	DET
admet-2753	126	62	appropriate	appropriate	ADJ
admet-2753	126	63	buffer	buffer	NOUN
admet-2753	126	64	was	be	AUX
admet-2753	126	65	pipetted	pipette	VERB
admet-2753	126	66	to	to	ADP
admet-2753	126	67	both	both	CCONJ
admet-2753	126	68	the	the	DET
admet-2753	126	69	donor	donor	NOUN
admet-2753	126	70	and	and	CCONJ
admet-2753	126	71	acceptor	acceptor	NOUN
admet-2753	126	72	sides	side	NOUN
admet-2753	126	73	.	.	PUNCT
admet-2753	127	1	then	then	ADV
admet-2753	127	2	,	,	PUNCT
admet-2753	127	3	various	various	ADJ
admet-2753	127	4	amounts	amount	NOUN
admet-2753	127	5	of	of	ADP
admet-2753	127	6	3	3	NUM
admet-2753	127	7	mg	mg	NOUN
admet-2753	127	8	ml-1	ml-1	CCONJ
admet-2753	128	1	methanol	methanol	NOUN
admet-2753	128	2	stock	stock	NOUN
admet-2753	128	3	solution	solution	NOUN
admet-2753	128	4	for	for	ADP
admet-2753	128	5	the	the	DET
admet-2753	128	6	drug	drug	NOUN
admet-2753	128	7	were	be	AUX
admet-2753	128	8	pipetted	pipette	VERB
admet-2753	128	9	to	to	ADP
admet-2753	128	10	the	the	DET
admet-2753	128	11	donor	donor	NOUN
admet-2753	128	12	side	side	NOUN
admet-2753	128	13	(	(	PUNCT
admet-2753	128	14	to	to	PART
admet-2753	128	15	reach	reach	VERB
admet-2753	128	16	a	a	DET
admet-2753	128	17	target	target	NOUN
admet-2753	128	18	concentration	concentration	NOUN
admet-2753	128	19	between	between	ADP
admet-2753	128	20	2.5	2.5	NUM
admet-2753	128	21	and	and	CCONJ
admet-2753	128	22	20	20	NUM
admet-2753	128	23	µg	µg	ADV
admet-2753	128	24	ml-1	ml-1	ADV
admet-2753	128	25	in	in	ADP
admet-2753	128	26	ph	ph	ADJ
admet-2753	128	27	10	10	NUM
admet-2753	128	28	prisma	prisma	NOUN
admet-2753	128	29	buffer	buffer	NOUN
admet-2753	128	30	and	and	CCONJ
admet-2753	128	31	2.5	2.5	NUM
admet-2753	128	32	and	and	CCONJ
admet-2753	128	33	50	50	NUM
admet-2753	128	34	µg	µg	ADV
admet-2753	128	35	ml-1	ml-1	ADV
admet-2753	128	36	in	in	ADP
admet-2753	128	37	ph	ph	ADJ
admet-2753	128	38	10	10	NUM
admet-2753	128	39	prisma	prisma	NOUN
admet-2753	128	40	buffer	buffer	NOUN
admet-2753	128	41	with	with	ADP
admet-2753	128	42	hp	hp	ADJ
admet-2753	128	43	-	-	PUNCT
admet-2753	128	44	b	b	NOUN
admet-2753	128	45	-	-	PUNCT
admet-2753	128	46	cd	cd	NOUN
admet-2753	128	47	)	)	PUNCT
admet-2753	128	48	.	.	PUNCT
admet-2753	129	1	the	the	DET
admet-2753	129	2	exact	exact	ADJ
admet-2753	129	3	amount	amount	NOUN
admet-2753	129	4	of	of	ADP
admet-2753	129	5	pure	pure	ADJ
admet-2753	129	6	methanol	methanol	NOUN
admet-2753	129	7	was	be	AUX
admet-2753	129	8	added	add	VERB
admet-2753	129	9	to	to	ADP
admet-2753	129	10	the	the	DET
admet-2753	129	11	donor	donor	NOUN
admet-2753	129	12	and	and	CCONJ
admet-2753	129	13	acceptor	acceptor	NOUN
admet-2753	129	14	side	side	NOUN
admet-2753	129	15	and	and	CCONJ
admet-2753	129	16	the	the	DET
admet-2753	129	17	maximum	maximum	ADJ
admet-2753	129	18	methanol	methanol	NOUN
admet-2753	129	19	concentration	concentration	NOUN
admet-2753	129	20	was	be	AUX
admet-2753	129	21	kept	keep	VERB
admet-2753	129	22	under	under	ADP
admet-2753	129	23	1.57	1.57	NUM
admet-2753	129	24	%	%	NOUN
admet-2753	129	25	to	to	PART
admet-2753	129	26	minimize	minimize	VERB
admet-2753	129	27	the	the	DET
admet-2753	129	28	solvent	solvent	ADJ
admet-2753	129	29	effect	effect	NOUN
admet-2753	129	30	on	on	ADP
admet-2753	129	31	the	the	DET
admet-2753	129	32	solubility	solubility	NOUN
admet-2753	129	33	and	and	CCONJ
admet-2753	129	34	permeability	permeability	NOUN
admet-2753	129	35	of	of	ADP
admet-2753	129	36	the	the	DET
admet-2753	129	37	api	api	NOUN
admet-2753	129	38	.	.	PUNCT
admet-2753	130	1	both	both	DET
admet-2753	130	2	cells	cell	NOUN
admet-2753	130	3	were	be	AUX
admet-2753	130	4	stirred	stir	VERB
admet-2753	130	5	at	at	ADP
admet-2753	130	6	37	37	NUM
admet-2753	130	7	°	°	ADP
admet-2753	130	8	c	c	NOUN
admet-2753	130	9	using	use	VERB
admet-2753	130	10	a	a	DET
admet-2753	130	11	magnetic	magnetic	ADJ
admet-2753	130	12	stirrer	stirrer	NOUN
admet-2753	130	13	at	at	ADP
admet-2753	130	14	250	250	NUM
admet-2753	130	15	rpm	rpm	NOUN
admet-2753	130	16	for	for	ADP
admet-2753	130	17	1	1	NUM
admet-2753	130	18	minute	minute	NOUN
admet-2753	130	19	,	,	PUNCT
admet-2753	130	20	and	and	CCONJ
admet-2753	130	21	then	then	ADV
admet-2753	130	22	the	the	DET
admet-2753	130	23	stirring	stir	VERB
admet-2753	130	24	speed	speed	NOUN
admet-2753	130	25	was	be	AUX
admet-2753	130	26	set	set	VERB
admet-2753	130	27	to	to	ADP
admet-2753	130	28	either	either	CCONJ
admet-2753	130	29	250	250	NUM
admet-2753	130	30	rpm	rpm	NOUN
admet-2753	130	31	or	or	CCONJ
admet-2753	130	32	0	0	NUM
admet-2753	130	33	rpm	rpm	NOUN
admet-2753	130	34	until	until	ADP
admet-2753	130	35	the	the	DET
admet-2753	130	36	end	end	NOUN
admet-2753	130	37	of	of	ADP
admet-2753	130	38	the	the	DET
admet-2753	130	39	measurements	measurement	NOUN
admet-2753	130	40	.	.	PUNCT
admet-2753	131	1	drug	drug	NOUN
admet-2753	131	2	concentrations	concentration	NOUN
admet-2753	131	3	at	at	ADP
admet-2753	131	4	the	the	DET
admet-2753	131	5	donor	donor	NOUN
admet-2753	131	6	and	and	CCONJ
admet-2753	131	7	acceptor	acceptor	NOUN
admet-2753	131	8	sides	side	NOUN
admet-2753	131	9	were	be	AUX
admet-2753	131	10	monitored	monitor	VERB
admet-2753	131	11	in	in	ADP
admet-2753	131	12	real	real	ADJ
admet-2753	131	13	-	-	PUNCT
admet-2753	131	14	time	time	NOUN
admet-2753	131	15	using	use	VERB
admet-2753	131	16	uv	uv	NOUN
admet-2753	131	17	probes	probe	NOUN
admet-2753	131	18	with	with	ADP
admet-2753	131	19	rainbow	rainbow	NOUN
admet-2753	131	20	apparatus	apparatus	NOUN
admet-2753	131	21	(	(	PUNCT
admet-2753	131	22	pion	pion	PROPN
admet-2753	131	23	inc	inc	PROPN
admet-2753	131	24	.	.	PROPN
admet-2753	131	25	,	,	PUNCT
admet-2753	131	26	billerica	billerica	PROPN
admet-2753	131	27	ma	ma	PROPN
admet-2753	131	28	,	,	PUNCT
admet-2753	131	29	usa	usa	PROPN
admet-2753	131	30	)	)	PUNCT
admet-2753	131	31	.	.	PUNCT
admet-2753	132	1	a	a	DET
admet-2753	132	2	second	second	ADJ
admet-2753	132	3	derivative	derivative	ADJ
admet-2753	132	4	method	method	NOUN
admet-2753	132	5	was	be	AUX
admet-2753	132	6	used	use	VERB
admet-2753	132	7	between	between	ADP
admet-2753	132	8	292	292	NUM
admet-2753	132	9	and	and	CCONJ
admet-2753	132	10	300	300	NUM
admet-2753	132	11	nm	nm	NOUN
admet-2753	132	12	to	to	PART
admet-2753	132	13	evaluate	evaluate	VERB
admet-2753	132	14	the	the	DET
admet-2753	132	15	spectra	spectra	NOUN
admet-2753	132	16	,	,	PUNCT
admet-2753	132	17	and	and	CCONJ
admet-2753	132	18	the	the	DET
admet-2753	132	19	papp	papp	NOUN
admet-2753	132	20	was	be	AUX
admet-2753	132	21	calculated	calculate	VERB
admet-2753	132	22	[	[	X
admet-2753	132	23	9	9	NUM
admet-2753	132	24	]	]	PUNCT
admet-2753	132	25	according	accord	VERB
admet-2753	132	26	to	to	ADP
admet-2753	132	27	equation	equation	NOUN
admet-2753	132	28	(	(	PUNCT
admet-2753	132	29	1	1	NUM
admet-2753	132	30	)	)	PUNCT
admet-2753	132	31	.	.	PUNCT
admet-2753	133	1	results	result	NOUN
admet-2753	133	2	and	and	CCONJ
admet-2753	133	3	discussion	discussion	NOUN
admet-2753	133	4	determination	determination	NOUN
admet-2753	133	5	of	of	ADP
admet-2753	133	6	the	the	DET
admet-2753	133	7	limiting	limit	VERB
admet-2753	133	8	step	step	NOUN
admet-2753	133	9	of	of	ADP
admet-2753	133	10	membrane	membrane	NOUN
admet-2753	133	11	transport	transport	NOUN
admet-2753	133	12	for	for	ADP
admet-2753	133	13	lipophilic	lipophilic	ADJ
admet-2753	133	14	and	and	CCONJ
admet-2753	133	15	size	size	NOUN
admet-2753	133	16	-	-	PUNCT
admet-2753	133	17	exclusion	exclusion	NOUN
admet-2753	133	18	membranes	membrane	NOUN
admet-2753	133	19	in	in	ADP
admet-2753	133	20	case	case	NOUN
admet-2753	133	21	of	of	ADP
admet-2753	133	22	the	the	DET
admet-2753	133	23	lipid	lipid	NOUN
admet-2753	133	24	membrane	membrane	NOUN
admet-2753	133	25	,	,	PUNCT
admet-2753	133	26	there	there	PRON
admet-2753	133	27	is	be	VERB
admet-2753	133	28	a	a	DET
admet-2753	133	29	fundamental	fundamental	ADJ
admet-2753	133	30	difference	difference	NOUN
admet-2753	133	31	in	in	ADP
admet-2753	133	32	diffusion	diffusion	NOUN
admet-2753	133	33	in	in	ADP
admet-2753	133	34	lipophilic	lipophilic	ADJ
admet-2753	133	35	and	and	CCONJ
admet-2753	133	36	aqueous	aqueous	ADJ
admet-2753	133	37	environment	environment	NOUN
admet-2753	133	38	;	;	PUNCT
admet-2753	133	39	therefore	therefore	ADV
admet-2753	133	40	,	,	PUNCT
admet-2753	133	41	the	the	DET
admet-2753	133	42	determination	determination	NOUN
admet-2753	133	43	of	of	ADP
admet-2753	133	44	the	the	DET
admet-2753	133	45	limiting	limit	VERB
admet-2753	133	46	step	step	NOUN
admet-2753	133	47	of	of	ADP
admet-2753	133	48	the	the	DET
admet-2753	133	49	transport	transport	NOUN
admet-2753	133	50	is	be	AUX
admet-2753	133	51	critical	critical	ADJ
admet-2753	133	52	in	in	ADP
admet-2753	133	53	case	case	NOUN
admet-2753	133	54	of	of	ADP
admet-2753	133	55	the	the	DET
admet-2753	133	56	lipophilic	lipophilic	ADJ
admet-2753	133	57	membrane	membrane	NOUN
admet-2753	133	58	.	.	PUNCT
admet-2753	134	1	therefore	therefore	ADV
admet-2753	134	2	,	,	PUNCT
admet-2753	134	3	the	the	DET
admet-2753	134	4	permeability	permeability	NOUN
admet-2753	134	5	-	-	PUNCT
admet-2753	134	6	ph	ph	NOUN
admet-2753	134	7	profile	profile	NOUN
admet-2753	134	8	was	be	AUX
admet-2753	134	9	measured	measure	VERB
admet-2753	134	10	,	,	PUNCT
admet-2753	134	11	and	and	CCONJ
admet-2753	134	12	the	the	DET
admet-2753	134	13	stirring	stir	VERB
admet-2753	134	14	speed	speed	NOUN
admet-2753	134	15	dependence	dependence	NOUN
admet-2753	134	16	was	be	AUX
admet-2753	134	17	also	also	ADV
admet-2753	134	18	tested	test	VERB
admet-2753	134	19	for	for	ADP
admet-2753	134	20	the	the	DET
admet-2753	134	21	lipophilic	lipophilic	ADJ
admet-2753	134	22	membrane	membrane	NOUN
admet-2753	134	23	.	.	PUNCT
admet-2753	135	1	figure	figure	NOUN
admet-2753	135	2	2	2	NUM
admet-2753	135	3	shows	show	VERB
admet-2753	135	4	the	the	DET
admet-2753	135	5	ph	ph	ADJ
admet-2753	135	6	dependence	dependence	NOUN
admet-2753	135	7	of	of	ADP
admet-2753	135	8	the	the	DET
admet-2753	135	9	apparent	apparent	ADJ
admet-2753	135	10	permeability	permeability	NOUN
admet-2753	135	11	of	of	ADP
admet-2753	135	12	car	car	NOUN
admet-2753	135	13	measured	measure	VERB
admet-2753	135	14	using	use	VERB
admet-2753	135	15	the	the	DET
admet-2753	135	16	n	n	CCONJ
admet-2753	135	17	-	-	PUNCT
admet-2753	135	18	dodecane	dodecane	NOUN
admet-2753	135	19	membrane	membrane	NOUN
admet-2753	135	20	at	at	ADP
admet-2753	135	21	the	the	DET
admet-2753	135	22	stirring	stirring	ADJ
admet-2753	135	23	rates	rate	NOUN
admet-2753	135	24	tested	test	VERB
admet-2753	135	25	.	.	PUNCT
admet-2753	136	1	at	at	ADP
admet-2753	136	2	ph	ph	PROPN
admet-2753	136	3	5	5	NUM
admet-2753	136	4	,	,	PUNCT
admet-2753	136	5	no	no	DET
admet-2753	136	6	drug	drug	NOUN
admet-2753	136	7	permeation	permeation	NOUN
admet-2753	136	8	through	through	ADP
admet-2753	136	9	the	the	DET
admet-2753	136	10	membrane	membrane	NOUN
admet-2753	136	11	was	be	AUX
admet-2753	136	12	observed	observe	VERB
admet-2753	136	13	at	at	ADP
admet-2753	136	14	any	any	PRON
admet-2753	136	15	of	of	ADP
admet-2753	136	16	the	the	DET
admet-2753	136	17	stirring	stirring	ADJ
admet-2753	136	18	rates	rate	NOUN
admet-2753	136	19	after	after	ADP
admet-2753	136	20	24	24	NUM
admet-2753	136	21	hours	hour	NOUN
admet-2753	136	22	.	.	PUNCT
admet-2753	137	1	in	in	ADP
admet-2753	137	2	the	the	DET
admet-2753	137	3	ph	ph	ADJ
admet-2753	137	4	range	range	NOUN
admet-2753	137	5	below	below	ADP
admet-2753	137	6	the	the	DET
admet-2753	137	7	pka	pka	NOUN
admet-2753	137	8	of	of	ADP
admet-2753	137	9	the	the	DET
admet-2753	137	10	active	active	ADJ
admet-2753	137	11	substance	substance	NOUN
admet-2753	137	12	(	(	PUNCT
admet-2753	137	13	pka	pka	NOUN
admet-2753	137	14	=	=	SYM
admet-2753	137	15	7.78	7.78	NUM
admet-2753	138	1	[	[	X
admet-2753	138	2	36,37	36,37	NUM
admet-2753	138	3	]	]	X
admet-2753	138	4	)	)	PUNCT
admet-2753	138	5	,	,	PUNCT
admet-2753	138	6	the	the	DET
admet-2753	138	7	slope	slope	NOUN
admet-2753	138	8	of	of	ADP
admet-2753	138	9	the	the	DET
admet-2753	138	10	curves	curve	NOUN
admet-2753	138	11	is	be	AUX
admet-2753	138	12	around	around	ADP
admet-2753	138	13	+1	+1	PROPN
admet-2753	138	14	.	.	PUNCT
admet-2753	139	1	the	the	DET
admet-2753	139	2	permeability	permeability	NOUN
admet-2753	139	3	of	of	ADP
admet-2753	139	4	car	car	NOUN
admet-2753	139	5	is	be	AUX
admet-2753	139	6	very	very	ADV
admet-2753	139	7	low	low	ADJ
admet-2753	139	8	at	at	ADP
admet-2753	139	9	ph	ph	NOUN
admet-2753	139	10	5	5	NUM
admet-2753	139	11	and	and	CCONJ
admet-2753	139	12	6	6	NUM
admet-2753	139	13	,	,	PUNCT
admet-2753	139	14	as	as	SCONJ
admet-2753	139	15	car	car	NOUN
admet-2753	139	16	is	be	AUX
admet-2753	139	17	overwhelmingly	overwhelmingly	ADV
admet-2753	139	18	ionized	ionize	VERB
admet-2753	139	19	in	in	ADP
admet-2753	139	20	solution	solution	NOUN
admet-2753	139	21	.	.	PUNCT
admet-2753	140	1	at	at	ADP
admet-2753	140	2	this	this	DET
admet-2753	140	3	range	range	NOUN
admet-2753	140	4	,	,	PUNCT
admet-2753	140	5	the	the	DET
admet-2753	140	6	apparent	apparent	ADJ
admet-2753	140	7	permeability	permeability	NOUN
admet-2753	140	8	curves	curve	NOUN
admet-2753	140	9	closely	closely	ADV
admet-2753	140	10	approximate	approximate	VERB
admet-2753	140	11	the	the	DET
admet-2753	140	12	membrane	membrane	NOUN
admet-2753	140	13	permeability	permeability	NOUN
admet-2753	140	14	curve	curve	NOUN
admet-2753	140	15	(	(	PUNCT
admet-2753	140	16	log	log	NOUN
admet-2753	140	17	pm	pm	NOUN
admet-2753	140	18	)	)	PUNCT
admet-2753	140	19	.	.	PUNCT
admet-2753	141	1	as	as	SCONJ
admet-2753	141	2	the	the	DET
admet-2753	141	3	ph	ph	NOUN
admet-2753	141	4	is	be	AUX
admet-2753	141	5	increased	increase	VERB
admet-2753	141	6	,	,	PUNCT
admet-2753	141	7	the	the	DET
admet-2753	141	8	molecule	molecule	NOUN
admet-2753	141	9	with	with	ADP
admet-2753	141	10	a	a	DET
admet-2753	141	11	weak	weak	ADJ
admet-2753	141	12	basic	basic	ADJ
admet-2753	141	13	character	character	NOUN
admet-2753	141	14	shows	show	VERB
admet-2753	141	15	increasing	increase	VERB
admet-2753	141	16	permeability	permeability	NOUN
admet-2753	141	17	,	,	PUNCT
admet-2753	141	18	with	with	ADP
admet-2753	141	19	the	the	DET
admet-2753	141	20	curves	curve	NOUN
admet-2753	141	21	flattening	flattening	NOUN
admet-2753	141	22	at	at	ADP
admet-2753	141	23	ph	ph	ADJ
admet-2753	141	24	ranges	range	NOUN
admet-2753	141	25	higher	high	ADJ
admet-2753	141	26	than	than	ADP
admet-2753	141	27	the	the	DET
admet-2753	141	28	pka	pka	PROPN
admet-2753	141	29	.	.	PUNCT
admet-2753	142	1	the	the	DET
admet-2753	142	2	apparent	apparent	ADJ
admet-2753	142	3	permeability	permeability	NOUN
admet-2753	142	4	curves	curve	NOUN
admet-2753	142	5	are	be	AUX
admet-2753	142	6	shifted	shift	VERB
admet-2753	142	7	from	from	ADP
admet-2753	142	8	the	the	DET
admet-2753	142	9	membrane	membrane	NOUN
admet-2753	142	10	permeability	permeability	NOUN
admet-2753	142	11	curve	curve	NOUN
admet-2753	142	12	and	and	CCONJ
admet-2753	142	13	are	be	AUX
admet-2753	142	14	already	already	ADV
admet-2753	142	15	skewed	skewed	ADJ
admet-2753	142	16	before	before	SCONJ
admet-2753	142	17	the	the	DET
admet-2753	142	18	pka	pka	PROPN
admet-2753	142	19	value	value	NOUN
admet-2753	142	20	is	be	AUX
admet-2753	142	21	reached	reach	VERB
admet-2753	142	22	.	.	PUNCT
admet-2753	143	1	figure	figure	NOUN
admet-2753	143	2	2	2	NUM
admet-2753	143	3	shows	show	VERB
admet-2753	143	4	that	that	SCONJ
admet-2753	143	5	the	the	DET
admet-2753	143	6	transport	transport	NOUN
admet-2753	143	7	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	VERB
admet-2753	143	8	p.	p.	PROPN
admet-2753	143	9	tőzsér	tőzsér	PROPN
admet-2753	143	10	et	et	PROPN
admet-2753	143	11	al	al	PROPN
admet-2753	143	12	.	.	PROPN
admet-2753	143	13	admet	admet	PROPN
admet-2753	143	14	&	&	CCONJ
admet-2753	143	15	dmpk	dmpk	PROPN
admet-2753	143	16	13(4	13(4	NUM
admet-2753	143	17	)	)	PUNCT
admet-2753	143	18	(	(	PUNCT
admet-2753	143	19	2025	2025	NUM
admet-2753	143	20	)	)	PUNCT
admet-2753	143	21	2753	2753	NUM
admet-2753	143	22	8	8	NUM
admet-2753	143	23	is	be	AUX
admet-2753	143	24	membrane	membrane	NOUN
admet-2753	143	25	-	-	PUNCT
admet-2753	143	26	limited	limit	VERB
admet-2753	143	27	at	at	ADP
admet-2753	143	28	ph	ph	PROPN
admet-2753	143	29	6	6	NUM
admet-2753	143	30	and	and	CCONJ
admet-2753	143	31	7	7	NUM
admet-2753	143	32	(	(	PUNCT
admet-2753	143	33	phs	phs	NOUN
admet-2753	143	34	lower	low	ADJ
admet-2753	143	35	than	than	ADP
admet-2753	143	36	pka	pka	PROPN
admet-2753	143	37	)	)	PUNCT
admet-2753	143	38	.	.	PUNCT
admet-2753	144	1	at	at	ADP
admet-2753	144	2	higher	high	ADJ
admet-2753	144	3	ph	ph	ADJ
admet-2753	144	4	values	value	NOUN
admet-2753	144	5	(	(	PUNCT
admet-2753	144	6	ph	ph	NOUN
admet-2753	144	7	9.5	9.5	NUM
admet-2753	144	8	and	and	CCONJ
admet-2753	144	9	10	10	NUM
admet-2753	144	10	)	)	PUNCT
admet-2753	144	11	,	,	PUNCT
admet-2753	144	12	where	where	SCONJ
admet-2753	144	13	the	the	DET
admet-2753	144	14	drug	drug	NOUN
admet-2753	144	15	is	be	AUX
admet-2753	144	16	mostly	mostly	ADV
admet-2753	144	17	present	present	ADJ
admet-2753	144	18	in	in	ADP
admet-2753	144	19	neutral	neutral	ADJ
admet-2753	144	20	form	form	NOUN
admet-2753	144	21	,	,	PUNCT
admet-2753	144	22	the	the	DET
admet-2753	144	23	transport	transport	NOUN
admet-2753	144	24	becomes	become	VERB
admet-2753	144	25	uwl	uwl	ADV
admet-2753	144	26	-	-	PUNCT
admet-2753	144	27	limited	limited	ADJ
admet-2753	144	28	.	.	PUNCT
admet-2753	145	1	the	the	DET
admet-2753	145	2	results	result	NOUN
admet-2753	145	3	of	of	ADP
admet-2753	145	4	the	the	DET
admet-2753	145	5	stirring	stirring	ADJ
admet-2753	145	6	rate	rate	NOUN
admet-2753	145	7	study	study	NOUN
admet-2753	145	8	also	also	ADV
admet-2753	145	9	support	support	VERB
admet-2753	145	10	that	that	DET
admet-2753	145	11	conclusion	conclusion	NOUN
admet-2753	145	12	,	,	PUNCT
admet-2753	145	13	since	since	SCONJ
admet-2753	145	14	at	at	ADP
admet-2753	145	15	ph	ph	PROPN
admet-2753	145	16	6	6	NUM
admet-2753	145	17	and	and	CCONJ
admet-2753	145	18	7	7	NUM
admet-2753	145	19	,	,	PUNCT
admet-2753	145	20	there	there	PRON
admet-2753	145	21	was	be	VERB
admet-2753	145	22	no	no	DET
admet-2753	145	23	significant	significant	ADJ
admet-2753	145	24	effect	effect	NOUN
admet-2753	145	25	found	find	VERB
admet-2753	145	26	on	on	ADP
admet-2753	145	27	the	the	DET
admet-2753	145	28	apparent	apparent	ADJ
admet-2753	145	29	permeability	permeability	NOUN
admet-2753	145	30	,	,	PUNCT
admet-2753	145	31	while	while	SCONJ
admet-2753	145	32	at	at	ADP
admet-2753	145	33	higher	high	ADJ
admet-2753	145	34	phs	phs	NOUN
admet-2753	145	35	,	,	PUNCT
admet-2753	145	36	the	the	DET
admet-2753	145	37	apparent	apparent	ADJ
admet-2753	145	38	permeability	permeability	NOUN
admet-2753	145	39	,	,	PUNCT
admet-2753	145	40	therefore	therefore	ADV
admet-2753	145	41	,	,	PUNCT
admet-2753	145	42	the	the	DET
admet-2753	145	43	uwl	uwl	NOUN
admet-2753	145	44	was	be	AUX
admet-2753	145	45	significantly	significantly	ADV
admet-2753	145	46	reduced	reduce	VERB
admet-2753	145	47	by	by	ADP
admet-2753	145	48	increasing	increase	VERB
admet-2753	145	49	the	the	DET
admet-2753	145	50	stirring	stir	VERB
admet-2753	145	51	speed	speed	NOUN
admet-2753	145	52	.	.	PUNCT
admet-2753	146	1	ph	ph	ADJ
admet-2753	146	2	figure	figure	NOUN
admet-2753	146	3	2	2	NUM
admet-2753	146	4	.	.	PUNCT
admet-2753	146	5	apparent	apparent	ADJ
admet-2753	146	6	permeability	permeability	NOUN
admet-2753	146	7	-	-	PUNCT
admet-2753	146	8	ph	ph	NOUN
admet-2753	146	9	profile	profile	NOUN
admet-2753	146	10	of	of	ADP
admet-2753	146	11	car	car	NOUN
admet-2753	146	12	measured	measure	VERB
admet-2753	146	13	using	use	VERB
admet-2753	146	14	lipophilic	lipophilic	ADJ
admet-2753	146	15	membrane	membrane	NOUN
admet-2753	146	16	in	in	ADP
admet-2753	146	17	the	the	DET
admet-2753	146	18	case	case	NOUN
admet-2753	146	19	of	of	ADP
admet-2753	146	20	the	the	DET
admet-2753	146	21	lipophilic	lipophilic	ADJ
admet-2753	146	22	membrane	membrane	NOUN
admet-2753	146	23	,	,	PUNCT
admet-2753	146	24	the	the	DET
admet-2753	146	25	flux	flux	NOUN
admet-2753	146	26	and	and	CCONJ
admet-2753	146	27	the	the	DET
admet-2753	146	28	apparent	apparent	ADJ
admet-2753	146	29	permeability	permeability	NOUN
admet-2753	146	30	results	result	NOUN
admet-2753	146	31	were	be	AUX
admet-2753	146	32	obtained	obtain	VERB
admet-2753	146	33	from	from	ADP
admet-2753	146	34	the	the	DET
admet-2753	146	35	initial	initial	ADJ
admet-2753	146	36	linear	linear	ADJ
admet-2753	146	37	phase	phase	NOUN
admet-2753	146	38	of	of	ADP
admet-2753	146	39	the	the	DET
admet-2753	146	40	acceptor	acceptor	NOUN
admet-2753	146	41	curves	curve	NOUN
admet-2753	146	42	in	in	ADP
admet-2753	146	43	each	each	DET
admet-2753	146	44	case	case	NOUN
admet-2753	146	45	.	.	PUNCT
admet-2753	147	1	the	the	DET
admet-2753	147	2	gutknecht	gutknecht	PROPN
admet-2753	147	3	method	method	NOUN
admet-2753	147	4	[	[	X
admet-2753	147	5	42	42	NUM
admet-2753	147	6	-	-	SYM
admet-2753	147	7	45	45	NUM
admet-2753	147	8	]	]	PUNCT
admet-2753	147	9	was	be	AUX
admet-2753	147	10	used	use	VERB
admet-2753	147	11	to	to	PART
admet-2753	147	12	determine	determine	VERB
admet-2753	147	13	the	the	DET
admet-2753	147	14	permeability	permeability	NOUN
admet-2753	147	15	of	of	ADP
admet-2753	147	16	car	car	NOUN
admet-2753	147	17	at	at	ADP
admet-2753	147	18	all	all	DET
admet-2753	147	19	stirring	stir	VERB
admet-2753	147	20	rates	rate	NOUN
admet-2753	147	21	.	.	PUNCT
admet-2753	148	1	the	the	DET
admet-2753	148	2	average	average	NOUN
admet-2753	148	3	of	of	ADP
admet-2753	148	4	the	the	DET
admet-2753	148	5	membrane	membrane	NOUN
admet-2753	148	6	permeability	permeability	NOUN
admet-2753	148	7	of	of	ADP
admet-2753	148	8	the	the	DET
admet-2753	148	9	neutral	neutral	ADJ
admet-2753	148	10	unbound	unbound	NOUN
admet-2753	148	11	drug	drug	NOUN
admet-2753	148	12	(	(	PUNCT
admet-2753	148	13	pmembrane	pmembrane	NOUN
admet-2753	148	14	,	,	PUNCT
admet-2753	148	15	lipophilic	lipophilic	NOUN
admet-2753	148	16	,	,	PUNCT
admet-2753	148	17	u	u	NOUN
admet-2753	148	18	,	,	PUNCT
admet-2753	148	19	0	0	NUM
admet-2753	148	20	)	)	PUNCT
admet-2753	148	21	was	be	AUX
admet-2753	148	22	found	find	VERB
admet-2753	148	23	to	to	PART
admet-2753	148	24	be	be	AUX
admet-2753	148	25	2.8910	2.8910	NUM
admet-2753	148	26	-	-	PUNCT
admet-2753	148	27	4±0.52310	4±0.52310	NUM
admet-2753	148	28	-	-	PUNCT
admet-2753	148	29	4	4	NUM
admet-2753	148	30	cm	cm	NOUN
admet-2753	148	31	s-1	s-1	NOUN
admet-2753	148	32	(	(	PUNCT
admet-2753	148	33	log	log	NOUN
admet-2753	148	34	pmembrane	pmembrane	NOUN
admet-2753	148	35	,	,	PUNCT
admet-2753	148	36	lipophilic	lipophilic	NOUN
admet-2753	148	37	,	,	PUNCT
admet-2753	148	38	u	u	NOUN
admet-2753	148	39	,	,	PUNCT
admet-2753	148	40	0	0	PUNCT
admet-2753	149	1	=	=	SYM
admet-2753	150	1	=	=	SYM
admet-2753	151	1	-3.54	-3.54	NUM
admet-2753	151	2	±	±	NUM
admet-2753	151	3	0.08	0.08	NUM
admet-2753	151	4	)	)	PUNCT
admet-2753	151	5	.	.	PUNCT
admet-2753	152	1	the	the	DET
admet-2753	152	2	puwl	puwl	NOUN
admet-2753	152	3	,	,	PUNCT
admet-2753	152	4	pm	pm	NOUN
admet-2753	152	5	,	,	PUNCT
admet-2753	152	6	duwl	duwl	NOUN
admet-2753	152	7	and	and	CCONJ
admet-2753	152	8	huwl	huwl	NOUN
admet-2753	152	9	values	value	NOUN
admet-2753	152	10	were	be	AUX
admet-2753	152	11	calculated	calculate	VERB
admet-2753	152	12	using	use	VERB
admet-2753	152	13	equations	equation	NOUN
admet-2753	152	14	(	(	PUNCT
admet-2753	152	15	2	2	NUM
admet-2753	152	16	)	)	PUNCT
admet-2753	152	17	to	to	ADP
admet-2753	152	18	(	(	PUNCT
admet-2753	152	19	12	12	NUM
admet-2753	152	20	)	)	PUNCT
admet-2753	152	21	and	and	CCONJ
admet-2753	152	22	are	be	AUX
admet-2753	152	23	presented	present	VERB
admet-2753	152	24	in	in	ADP
admet-2753	152	25	table	table	NOUN
admet-2753	152	26	s1	s1	NOUN
admet-2753	152	27	(	(	PUNCT
admet-2753	152	28	supplementary	supplementary	ADJ
admet-2753	152	29	material	material	NOUN
admet-2753	152	30	)	)	PUNCT
admet-2753	152	31	.	.	PUNCT
admet-2753	153	1	in	in	ADP
admet-2753	153	2	contrast	contrast	NOUN
admet-2753	153	3	,	,	PUNCT
admet-2753	153	4	in	in	ADP
admet-2753	153	5	the	the	DET
admet-2753	153	6	case	case	NOUN
admet-2753	153	7	of	of	ADP
admet-2753	153	8	a	a	DET
admet-2753	153	9	size	size	NOUN
admet-2753	153	10	-	-	PUNCT
admet-2753	153	11	exclusion	exclusion	NOUN
admet-2753	153	12	membrane	membrane	NOUN
admet-2753	153	13	,	,	PUNCT
admet-2753	153	14	both	both	CCONJ
admet-2753	153	15	the	the	DET
admet-2753	153	16	uwl	uwl	NOUN
admet-2753	153	17	and	and	CCONJ
admet-2753	153	18	the	the	DET
admet-2753	153	19	membrane	membrane	NOUN
admet-2753	153	20	permeation	permeation	NOUN
admet-2753	153	21	mean	mean	VERB
admet-2753	153	22	aqueous	aqueous	ADJ
admet-2753	153	23	diffusion	diffusion	NOUN
admet-2753	153	24	.	.	PUNCT
admet-2753	154	1	however	however	ADV
admet-2753	154	2	,	,	PUNCT
admet-2753	154	3	these	these	DET
admet-2753	154	4	two	two	NUM
admet-2753	154	5	aqueous	aqueous	ADJ
admet-2753	154	6	environments	environment	NOUN
admet-2753	154	7	may	may	AUX
admet-2753	154	8	differ	differ	VERB
admet-2753	154	9	significantly	significantly	ADV
admet-2753	154	10	due	due	ADP
admet-2753	154	11	to	to	ADP
admet-2753	154	12	the	the	DET
admet-2753	154	13	drug	drug	NOUN
admet-2753	154	14	's	's	PART
admet-2753	154	15	molecular	molecular	ADJ
admet-2753	154	16	hydration	hydration	NOUN
admet-2753	154	17	and	and	CCONJ
admet-2753	154	18	potential	potential	ADJ
admet-2753	154	19	interaction	interaction	NOUN
admet-2753	154	20	with	with	ADP
admet-2753	154	21	the	the	DET
admet-2753	154	22	filter	filter	NOUN
admet-2753	154	23	material	material	NOUN
admet-2753	154	24	.	.	PUNCT
admet-2753	155	1	there	there	PRON
admet-2753	155	2	are	be	VERB
admet-2753	155	3	practical	practical	ADJ
admet-2753	155	4	limitations	limitation	NOUN
admet-2753	155	5	in	in	ADP
admet-2753	155	6	determining	determine	VERB
admet-2753	155	7	the	the	DET
admet-2753	155	8	limiting	limit	VERB
admet-2753	155	9	step	step	NOUN
admet-2753	155	10	of	of	ADP
admet-2753	155	11	transport	transport	NOUN
admet-2753	155	12	for	for	ADP
admet-2753	155	13	size	size	NOUN
admet-2753	155	14	-	-	PUNCT
admet-2753	155	15	exclusion	exclusion	NOUN
admet-2753	155	16	membranes	membrane	NOUN
admet-2753	155	17	:	:	PUNCT
admet-2753	155	18	since	since	SCONJ
admet-2753	155	19	these	these	DET
admet-2753	155	20	membranes	membrane	NOUN
admet-2753	155	21	can	can	AUX
admet-2753	155	22	not	not	PART
admet-2753	155	23	differentiate	differentiate	VERB
admet-2753	155	24	between	between	ADP
admet-2753	155	25	ionized	ionized	ADJ
admet-2753	155	26	and	and	CCONJ
admet-2753	155	27	neutral	neutral	ADJ
admet-2753	155	28	molecules	molecule	NOUN
admet-2753	155	29	,	,	PUNCT
admet-2753	155	30	due	due	ADP
admet-2753	155	31	to	to	ADP
admet-2753	155	32	the	the	DET
admet-2753	155	33	absence	absence	NOUN
admet-2753	155	34	of	of	ADP
admet-2753	155	35	lipophilic	lipophilic	ADJ
admet-2753	155	36	domain	domain	NOUN
admet-2753	155	37	,	,	PUNCT
admet-2753	155	38	the	the	DET
admet-2753	155	39	permeability	permeability	NOUN
admet-2753	155	40	shows	show	VERB
admet-2753	155	41	no	no	DET
admet-2753	155	42	ph	ph	ADJ
admet-2753	155	43	dependence	dependence	NOUN
admet-2753	155	44	(	(	PUNCT
admet-2753	155	45	papp	papp	NOUN
admet-2753	155	46	=	=	SYM
admet-2753	155	47	5.9	5.9	NUM
admet-2753	155	48	±	±	NUM
admet-2753	155	49	0.8	0.8	NUM
admet-2753	155	50	cm	cm	NOUN
admet-2753	155	51	s-1	s-1	NOUN
admet-2753	155	52	at	at	ADP
admet-2753	155	53	ph	ph	PROPN
admet-2753	155	54	6	6	NUM
admet-2753	155	55	and	and	CCONJ
admet-2753	155	56	papp	papp	NOUN
admet-2753	155	57	=	=	SYM
admet-2753	155	58	5.2	5.2	NUM
admet-2753	155	59	±	±	NUM
admet-2753	155	60	0.7	0.7	NUM
admet-2753	155	61	cm	cm	NOUN
admet-2753	155	62	s-1	s-1	NOUN
admet-2753	155	63	at	at	ADP
admet-2753	155	64	ph	ph	PROPN
admet-2753	155	65	10	10	NUM
admet-2753	155	66	in	in	ADP
admet-2753	155	67	case	case	NOUN
admet-2753	155	68	of	of	ADP
admet-2753	155	69	1	1	NUM
admet-2753	155	70	kda	kda	NOUN
admet-2753	155	71	mwco	mwco	NOUN
admet-2753	155	72	membrane	membrane	NOUN
admet-2753	155	73	)	)	PUNCT
admet-2753	155	74	.	.	PUNCT
admet-2753	156	1	therefore	therefore	ADV
admet-2753	156	2	,	,	PUNCT
admet-2753	156	3	standard	standard	ADJ
admet-2753	156	4	methods	method	NOUN
admet-2753	156	5	,	,	PUNCT
admet-2753	156	6	such	such	ADJ
admet-2753	156	7	as	as	ADP
admet-2753	156	8	permeability	permeability	NOUN
admet-2753	156	9	-	-	PUNCT
admet-2753	156	10	ph	ph	ADJ
admet-2753	156	11	profiling	profiling	NOUN
admet-2753	156	12	,	,	PUNCT
admet-2753	156	13	are	be	AUX
admet-2753	156	14	not	not	PART
admet-2753	156	15	suitable	suitable	ADJ
admet-2753	156	16	for	for	ADP
admet-2753	156	17	calculating	calculate	VERB
admet-2753	156	18	the	the	DET
admet-2753	156	19	size	size	NOUN
admet-2753	156	20	of	of	ADP
admet-2753	156	21	the	the	DET
admet-2753	156	22	uwl	uwl	NOUN
admet-2753	156	23	or	or	CCONJ
admet-2753	156	24	determining	determine	VERB
admet-2753	156	25	the	the	DET
admet-2753	156	26	limiting	limit	VERB
admet-2753	156	27	step	step	NOUN
admet-2753	156	28	of	of	ADP
admet-2753	156	29	transport	transport	NOUN
admet-2753	156	30	.	.	PUNCT
admet-2753	157	1	only	only	ADV
admet-2753	157	2	stirring	stir	VERB
admet-2753	157	3	speed	speed	NOUN
admet-2753	157	4	dependence	dependence	NOUN
admet-2753	157	5	can	can	AUX
admet-2753	157	6	be	be	AUX
admet-2753	157	7	tested	test	VERB
admet-2753	157	8	(	(	PUNCT
admet-2753	157	9	figure	figure	NOUN
admet-2753	157	10	3	3	NUM
admet-2753	157	11	)	)	PUNCT
admet-2753	157	12	,	,	PUNCT
admet-2753	157	13	which	which	PRON
admet-2753	157	14	proves	prove	VERB
admet-2753	157	15	the	the	DET
admet-2753	157	16	existence	existence	NOUN
admet-2753	157	17	of	of	ADP
admet-2753	157	18	the	the	DET
admet-2753	157	19	uwl	uwl	NOUN
admet-2753	157	20	,	,	PUNCT
admet-2753	157	21	but	but	CCONJ
admet-2753	157	22	according	accord	VERB
admet-2753	157	23	to	to	ADP
admet-2753	157	24	sugano	sugano	NOUN
admet-2753	157	25	[	[	X
admet-2753	157	26	10,52	10,52	NUM
admet-2753	157	27	]	]	X
admet-2753	157	28	,	,	PUNCT
admet-2753	157	29	the	the	DET
admet-2753	157	30	insensitiveness	insensitiveness	NOUN
admet-2753	157	31	of	of	ADP
admet-2753	157	32	apparent	apparent	ADJ
admet-2753	157	33	permeability	permeability	NOUN
admet-2753	157	34	to	to	ADP
admet-2753	157	35	the	the	DET
admet-2753	157	36	stirring	stirring	ADJ
admet-2753	157	37	speed	speed	NOUN
admet-2753	157	38	increment	increment	NOUN
admet-2753	157	39	does	do	AUX
admet-2753	157	40	not	not	PART
admet-2753	157	41	prove	prove	VERB
admet-2753	157	42	that	that	SCONJ
admet-2753	157	43	the	the	DET
admet-2753	157	44	transport	transport	NOUN
admet-2753	157	45	is	be	AUX
admet-2753	157	46	membrane	membrane	NOUN
admet-2753	157	47	-	-	PUNCT
admet-2753	157	48	limited	limit	VERB
admet-2753	157	49	.	.	PUNCT
admet-2753	158	1	while	while	SCONJ
admet-2753	158	2	the	the	DET
admet-2753	158	3	direct	direct	ADJ
admet-2753	158	4	approach	approach	NOUN
admet-2753	158	5	was	be	AUX
admet-2753	158	6	not	not	PART
admet-2753	158	7	found	find	VERB
admet-2753	158	8	to	to	PART
admet-2753	158	9	measure	measure	VERB
admet-2753	158	10	the	the	DET
admet-2753	158	11	puwl	puwl	NOUN
admet-2753	158	12	for	for	ADP
admet-2753	158	13	the	the	DET
admet-2753	158	14	size	size	NOUN
admet-2753	158	15	-	-	PUNCT
admet-2753	158	16	exclusion	exclusion	NOUN
admet-2753	158	17	membranes	membrane	NOUN
admet-2753	158	18	,	,	PUNCT
admet-2753	158	19	using	use	VERB
admet-2753	158	20	the	the	DET
admet-2753	158	21	same	same	ADJ
admet-2753	158	22	apparatus	apparatus	NOUN
admet-2753	158	23	,	,	PUNCT
admet-2753	158	24	it	it	PRON
admet-2753	158	25	can	can	AUX
admet-2753	158	26	be	be	AUX
admet-2753	158	27	assumed	assume	VERB
admet-2753	158	28	that	that	SCONJ
admet-2753	158	29	the	the	DET
admet-2753	158	30	uwl	uwl	NOUN
admet-2753	158	31	permeabilities	permeability	NOUN
admet-2753	158	32	and	and	CCONJ
admet-2753	158	33	the	the	DET
admet-2753	158	34	thickness	thickness	NOUN
admet-2753	158	35	of	of	ADP
admet-2753	158	36	the	the	DET
admet-2753	158	37	uwl	uwl	NOUN
admet-2753	158	38	are	be	AUX
admet-2753	158	39	the	the	DET
admet-2753	158	40	same	same	ADJ
admet-2753	158	41	for	for	ADP
admet-2753	158	42	lipophilic	lipophilic	ADJ
admet-2753	158	43	and	and	CCONJ
admet-2753	158	44	size	size	NOUN
admet-2753	158	45	-	-	PUNCT
admet-2753	158	46	exclusion	exclusion	NOUN
admet-2753	158	47	membranes	membrane	NOUN
admet-2753	158	48	when	when	SCONJ
admet-2753	158	49	using	use	VERB
admet-2753	158	50	the	the	DET
admet-2753	158	51	same	same	ADJ
admet-2753	158	52	donor	donor	NOUN
admet-2753	158	53	,	,	PUNCT
admet-2753	158	54	acceptor	acceptor	NOUN
admet-2753	158	55	media	medium	NOUN
admet-2753	158	56	and	and	CCONJ
admet-2753	158	57	stirring	stirring	NOUN
admet-2753	158	58	speed	speed	NOUN
admet-2753	158	59	.	.	PUNCT
admet-2753	159	1	in	in	ADP
admet-2753	159	2	a	a	DET
admet-2753	159	3	non	non	ADJ
admet-2753	159	4	-	-	ADJ
admet-2753	159	5	stirred	stirred	ADJ
admet-2753	159	6	environment	environment	NOUN
admet-2753	159	7	,	,	PUNCT
admet-2753	159	8	where	where	SCONJ
admet-2753	159	9	the	the	DET
admet-2753	159	10	uwl	uwl	NOUN
admet-2753	159	11	is	be	AUX
admet-2753	159	12	the	the	DET
admet-2753	159	13	thickest	thick	ADJ
admet-2753	159	14	,	,	PUNCT
admet-2753	159	15	and	and	CCONJ
admet-2753	159	16	puwl	puwl	PROPN
admet-2753	159	17	is	be	AUX
admet-2753	159	18	very	very	ADV
admet-2753	159	19	close	close	ADJ
admet-2753	159	20	to	to	ADP
admet-2753	159	21	papp	papp	NOUN
admet-2753	159	22	,	,	PUNCT
admet-2753	159	23	(	(	PUNCT
admet-2753	159	24	see	see	VERB
admet-2753	159	25	table	table	NOUN
admet-2753	159	26	s2	s2	PROPN
admet-2753	159	27	)	)	PUNCT
admet-2753	159	28	,	,	PUNCT
admet-2753	159	29	in	in	ADP
admet-2753	159	30	the	the	DET
admet-2753	159	31	case	case	NOUN
admet-2753	159	32	of	of	ADP
admet-2753	159	33	all	all	DET
admet-2753	159	34	3	3	NUM
admet-2753	159	35	membranes	membrane	NOUN
admet-2753	159	36	in	in	ADP
admet-2753	159	37	the	the	DET
admet-2753	159	38	plain	plain	ADJ
admet-2753	159	39	buffer	buffer	NOUN
admet-2753	159	40	,	,	PUNCT
admet-2753	159	41	similar	similar	ADJ
admet-2753	159	42	papp	papp	NOUN
admet-2753	159	43	values	value	NOUN
admet-2753	159	44	could	could	AUX
admet-2753	159	45	be	be	AUX
admet-2753	159	46	measured	measure	VERB
admet-2753	159	47	.	.	PUNCT
admet-2753	160	1	these	these	DET
admet-2753	160	2	results	result	NOUN
admet-2753	160	3	support	support	VERB
admet-2753	160	4	the	the	DET
admet-2753	160	5	assumption	assumption	NOUN
admet-2753	160	6	that	that	SCONJ
admet-2753	160	7	the	the	DET
admet-2753	160	8	puwl	puwl	NOUN
admet-2753	160	9	is	be	AUX
admet-2753	160	10	the	the	DET
admet-2753	160	11	same	same	ADJ
admet-2753	160	12	for	for	ADP
admet-2753	160	13	different	different	ADJ
admet-2753	160	14	membranes	membrane	NOUN
admet-2753	160	15	at	at	ADP
admet-2753	160	16	the	the	DET
admet-2753	160	17	given	give	VERB
admet-2753	160	18	experimental	experimental	ADJ
admet-2753	160	19	conditions	condition	NOUN
admet-2753	160	20	.	.	PUNCT
admet-2753	161	1	lo	lo	PROPN
admet-2753	161	2	g	g	PROPN
admet-2753	161	3	(	(	PUNCT
admet-2753	161	4	p	p	X
admet-2753	161	5	a	a	DET
admet-2753	161	6	p	p	X
admet-2753	161	7	p	p	X
admet-2753	161	8	/	/	SYM
admet-2753	161	9	c	c	NOUN
admet-2753	161	10	m	m	NOUN
admet-2753	161	11	s	s	NOUN
admet-2753	161	12	-1	-1	PUNCT
admet-2753	161	13	)	)	PUNCT
admet-2753	161	14	pm	pm	PROPN
admet-2753	161	15	admet	admet	PROPN
admet-2753	161	16	&	&	CCONJ
admet-2753	161	17	dmpk	dmpk	PROPN
admet-2753	161	18	13(4	13(4	NUM
admet-2753	161	19	)	)	PUNCT
admet-2753	161	20	(	(	PUNCT
admet-2753	161	21	2025	2025	NUM
admet-2753	161	22	)	)	PUNCT
admet-2753	161	23	2753	2753	NUM
admet-2753	161	24	comparison	comparison	NOUN
admet-2753	161	25	of	of	ADP
admet-2753	161	26	lipophilic	lipophilic	ADJ
admet-2753	161	27	and	and	CCONJ
admet-2753	161	28	size	size	NOUN
admet-2753	161	29	-	-	PUNCT
admet-2753	161	30	exclusion	exclusion	NOUN
admet-2753	161	31	membranes	membrane	NOUN
admet-2753	161	32	doi	doi	NOUN
admet-2753	161	33	:	:	PUNCT
admet-2753	161	34	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	161	35	9	9	NUM
admet-2753	161	36	considering	consider	VERB
admet-2753	161	37	the	the	DET
admet-2753	161	38	apparent	apparent	ADJ
admet-2753	161	39	permeability	permeability	NOUN
admet-2753	161	40	-	-	PUNCT
admet-2753	161	41	ph	ph	NOUN
admet-2753	161	42	profile	profile	NOUN
admet-2753	161	43	(	(	PUNCT
admet-2753	161	44	figure	figure	NOUN
admet-2753	161	45	2	2	NUM
admet-2753	161	46	)	)	PUNCT
admet-2753	161	47	and	and	CCONJ
admet-2753	161	48	the	the	DET
admet-2753	161	49	puwl	puwl	NOUN
admet-2753	161	50	and	and	CCONJ
admet-2753	161	51	pm	pm	VERB
admet-2753	161	52	values	value	NOUN
admet-2753	161	53	in	in	ADP
admet-2753	161	54	tables	table	NOUN
admet-2753	161	55	s1	s1	NOUN
admet-2753	161	56	and	and	CCONJ
admet-2753	161	57	s2	s2	PROPN
admet-2753	161	58	,	,	PUNCT
admet-2753	161	59	ph	ph	VERB
admet-2753	161	60	10	10	NUM
admet-2753	161	61	media	medium	NOUN
admet-2753	161	62	was	be	AUX
admet-2753	161	63	chosen	choose	VERB
admet-2753	161	64	for	for	ADP
admet-2753	161	65	the	the	DET
admet-2753	161	66	in	in	ADV
admet-2753	161	67	vitro	vitro	X
admet-2753	161	68	side	side	NOUN
admet-2753	161	69	-	-	PUNCT
admet-2753	161	70	by	by	ADP
admet-2753	161	71	-	-	PUNCT
admet-2753	161	72	side	side	NOUN
admet-2753	161	73	diffusion	diffusion	NOUN
admet-2753	161	74	cell	cell	NOUN
admet-2753	161	75	assays	assay	NOUN
admet-2753	161	76	to	to	PART
admet-2753	161	77	create	create	VERB
admet-2753	161	78	uwl	uwl	ADV
admet-2753	161	79	-	-	PUNCT
admet-2753	161	80	limited	limit	VERB
admet-2753	161	81	transport	transport	NOUN
admet-2753	161	82	conditions	condition	NOUN
admet-2753	161	83	when	when	SCONJ
admet-2753	161	84	a	a	DET
admet-2753	161	85	lipophilic	lipophilic	ADJ
admet-2753	161	86	membrane	membrane	NOUN
admet-2753	161	87	is	be	AUX
admet-2753	161	88	used	use	VERB
admet-2753	161	89	in	in	ADP
admet-2753	161	90	the	the	DET
admet-2753	161	91	absence	absence	NOUN
admet-2753	161	92	of	of	ADP
admet-2753	161	93	hp	hp	PROPN
admet-2753	161	94	-	-	PUNCT
admet-2753	161	95	β	β	NOUN
admet-2753	161	96	-	-	NOUN
admet-2753	161	97	cd	cd	NOUN
admet-2753	161	98	.	.	PUNCT
admet-2753	162	1	stirring	stir	VERB
admet-2753	162	2	rate	rate	NOUN
admet-2753	162	3	,	,	PUNCT
admet-2753	162	4	rpm	rpm	ADJ
admet-2753	162	5	stirring	stirring	NOUN
admet-2753	162	6	rate	rate	NOUN
admet-2753	162	7	,	,	PUNCT
admet-2753	162	8	rpm	rpm	ADJ
admet-2753	162	9	stirring	stirring	NOUN
admet-2753	162	10	rate	rate	NOUN
admet-2753	162	11	,	,	PUNCT
admet-2753	162	12	rpm	rpm	ADJ
admet-2753	162	13	figure	figure	NOUN
admet-2753	162	14	3	3	NUM
admet-2753	162	15	.	.	PUNCT
admet-2753	162	16	apparent	apparent	ADJ
admet-2753	162	17	permeability	permeability	NOUN
admet-2753	162	18	-	-	PUNCT
admet-2753	162	19	rpm	rpm	NOUN
admet-2753	162	20	profiles	profile	NOUN
admet-2753	162	21	for	for	ADP
admet-2753	162	22	lipophilic	lipophilic	ADJ
admet-2753	162	23	,	,	PUNCT
admet-2753	162	24	1	1	NUM
admet-2753	162	25	and	and	CCONJ
admet-2753	162	26	6	6	NUM
admet-2753	162	27	kda	kda	NOUN
admet-2753	162	28	size	size	NOUN
admet-2753	162	29	-	-	PUNCT
admet-2753	162	30	exclusion	exclusion	NOUN
admet-2753	162	31	membranes	membrane	NOUN
admet-2753	162	32	at	at	ADP
admet-2753	162	33	37	37	NUM
admet-2753	162	34	°	°	NOUN
admet-2753	162	35	c	c	NOUN
admet-2753	162	36	,	,	PUNCT
admet-2753	162	37	pure	pure	ADJ
admet-2753	162	38	ph	ph	ADJ
admet-2753	162	39	10	10	NUM
admet-2753	162	40	prisma	prisma	NOUN
admet-2753	162	41	buffer	buffer	NOUN
admet-2753	162	42	with	with	ADP
admet-2753	162	43	blue	blue	ADJ
admet-2753	162	44	dots	dot	NOUN
admet-2753	162	45	and	and	CCONJ
admet-2753	162	46	ph	ph	ADJ
admet-2753	162	47	10	10	NUM
admet-2753	162	48	prisma	prisma	NOUN
admet-2753	162	49	buffer	buffer	NOUN
admet-2753	162	50	containing	contain	VERB
admet-2753	162	51	15	15	NUM
admet-2753	162	52	mg	mg	NOUN
admet-2753	162	53	ml-1	ml-1	ADV
admet-2753	163	1	hp	hp	PROPN
admet-2753	163	2	-	-	PUNCT
admet-2753	163	3	β	β	NOUN
admet-2753	163	4	-	-	NOUN
admet-2753	163	5	cd	cd	NOUN
admet-2753	163	6	on	on	ADP
admet-2753	163	7	the	the	DET
admet-2753	163	8	donor	donor	NOUN
admet-2753	163	9	side	side	NOUN
admet-2753	163	10	with	with	ADP
admet-2753	163	11	orange	orange	NOUN
admet-2753	163	12	dots	dot	NOUN
admet-2753	163	13	phase	phase	NOUN
admet-2753	163	14	solubility	solubility	NOUN
admet-2753	163	15	study	study	NOUN
admet-2753	163	16	of	of	ADP
admet-2753	163	17	car	car	NOUN
admet-2753	163	18	hp	hp	PROPN
admet-2753	163	19	-	-	PUNCT
admet-2753	163	20	β	β	NOUN
admet-2753	163	21	-	-	ADJ
admet-2753	163	22	cd	cd	ADJ
admet-2753	163	23	complex	complex	NOUN
admet-2753	163	24	in	in	ADP
admet-2753	163	25	ph	ph	PROPN
admet-2753	163	26	10	10	NUM
admet-2753	163	27	prisma	prisma	NOUN
admet-2753	163	28	buffer	buffer	NOUN
admet-2753	163	29	figure	figure	NOUN
admet-2753	163	30	4	4	NUM
admet-2753	163	31	shows	show	VERB
admet-2753	163	32	the	the	DET
admet-2753	163	33	phase	phase	NOUN
admet-2753	163	34	solubility	solubility	NOUN
admet-2753	163	35	diagram	diagram	NOUN
admet-2753	163	36	of	of	ADP
admet-2753	163	37	car	car	NOUN
admet-2753	163	38	's	's	PART
admet-2753	163	39	two	two	NUM
admet-2753	163	40	polymorphic	polymorphic	ADJ
admet-2753	163	41	modifications	modification	NOUN
admet-2753	163	42	(	(	PUNCT
admet-2753	163	43	form	form	NOUN
admet-2753	163	44	i	i	PRON
admet-2753	163	45	and	and	CCONJ
admet-2753	163	46	form	form	PROPN
admet-2753	163	47	ii	ii	PROPN
admet-2753	163	48	)	)	PUNCT
admet-2753	163	49	.	.	PUNCT
admet-2753	164	1	a	a	DET
admet-2753	164	2	linear	linear	ADJ
admet-2753	164	3	correlation	correlation	NOUN
admet-2753	164	4	(	(	PUNCT
admet-2753	164	5	form	form	VERB
admet-2753	164	6	i	i	PRON
admet-2753	164	7	:	:	PUNCT
admet-2753	164	8	r2=0.9987	r2=0.9987	NOUN
admet-2753	164	9	;	;	PUNCT
admet-2753	164	10	form	form	NOUN
admet-2753	164	11	ii	ii	PROPN
admet-2753	164	12	:	:	PUNCT
admet-2753	164	13	r2=0.9952	r2=0.9952	NOUN
admet-2753	164	14	)	)	PUNCT
admet-2753	164	15	between	between	ADP
admet-2753	164	16	the	the	DET
admet-2753	164	17	active	active	ADJ
admet-2753	164	18	substance	substance	NOUN
admet-2753	164	19	's	's	PART
admet-2753	164	20	equilibrium	equilibrium	NOUN
admet-2753	164	21	solubility	solubility	NOUN
admet-2753	164	22	and	and	CCONJ
admet-2753	164	23	the	the	DET
admet-2753	164	24	solution	solution	NOUN
admet-2753	164	25	's	's	PART
admet-2753	164	26	hp	hp	PROPN
admet-2753	164	27	-	-	PUNCT
admet-2753	164	28	β	β	NOUN
admet-2753	164	29	-	-	ADJ
admet-2753	164	30	cd	cd	ADJ
admet-2753	164	31	content	content	NOUN
admet-2753	164	32	was	be	AUX
admet-2753	164	33	found	find	VERB
admet-2753	164	34	for	for	ADP
admet-2753	164	35	both	both	DET
admet-2753	164	36	form	form	NOUN
admet-2753	164	37	i	i	PRON
admet-2753	164	38	and	and	CCONJ
admet-2753	164	39	form	form	VERB
admet-2753	164	40	ii	ii	PROPN
admet-2753	164	41	modifications	modification	NOUN
admet-2753	164	42	.	.	PUNCT
admet-2753	165	1	this	this	PRON
admet-2753	165	2	indicates	indicate	VERB
admet-2753	165	3	that	that	SCONJ
admet-2753	165	4	the	the	DET
admet-2753	165	5	phase	phase	NOUN
admet-2753	165	6	solubility	solubility	NOUN
admet-2753	165	7	is	be	AUX
admet-2753	165	8	linear	linear	ADJ
admet-2753	165	9	at	at	ADP
admet-2753	165	10	the	the	DET
admet-2753	165	11	range	range	NOUN
admet-2753	165	12	of	of	ADP
admet-2753	165	13	hp	hp	PROPN
admet-2753	165	14	-	-	PUNCT
admet-2753	165	15	β	β	NOUN
admet-2753	165	16	-	-	ADJ
admet-2753	165	17	cd	cd	ADJ
admet-2753	165	18	concentrations	concentration	NOUN
admet-2753	165	19	studied	study	VERB
admet-2753	165	20	,	,	PUNCT
admet-2753	165	21	suggesting	suggest	VERB
admet-2753	165	22	that	that	SCONJ
admet-2753	165	23	the	the	DET
admet-2753	165	24	drug	drug	NOUN
admet-2753	165	25	forms	form	VERB
admet-2753	165	26	a	a	DET
admet-2753	165	27	1:1	1:1	NUM
admet-2753	165	28	stoichiometric	stoichiometric	NOUN
admet-2753	165	29	complex	complex	NOUN
admet-2753	165	30	with	with	ADP
admet-2753	165	31	hp	hp	PROPN
admet-2753	165	32	-	-	PUNCT
admet-2753	165	33	β	β	NOUN
admet-2753	165	34	-	-	NOUN
admet-2753	165	35	cd	cd	NOUN
admet-2753	165	36	[	[	X
admet-2753	165	37	53	53	NUM
admet-2753	165	38	-	-	SYM
admet-2753	165	39	55	55	NUM
admet-2753	165	40	]	]	PUNCT
admet-2753	165	41	.	.	PUNCT
admet-2753	166	1	chp	chp	PROPN
admet-2753	166	2	-	-	PUNCT
admet-2753	166	3	β	β	NOUN
admet-2753	166	4	-	-	NOUN
admet-2753	166	5	cd	cd	ADJ
admet-2753	166	6	/	/	SYM
admet-2753	166	7	mm	mm	PROPN
admet-2753	166	8	figure	figure	NOUN
admet-2753	166	9	4	4	NUM
admet-2753	166	10	.	.	NOUN
admet-2753	166	11	phase	phase	NOUN
admet-2753	166	12	-	-	PUNCT
admet-2753	166	13	solubility	solubility	NOUN
admet-2753	166	14	diagram	diagram	NOUN
admet-2753	166	15	of	of	ADP
admet-2753	166	16	car	car	NOUN
admet-2753	166	17	-	-	PUNCT
admet-2753	166	18	hp	hp	NOUN
admet-2753	166	19	-	-	PUNCT
admet-2753	166	20	β	β	NOUN
admet-2753	166	21	-	-	ADJ
admet-2753	166	22	cd	cd	ADJ
admet-2753	166	23	complex	complex	NOUN
admet-2753	166	24	,	,	PUNCT
admet-2753	166	25	ph	ph	ADJ
admet-2753	166	26	10	10	NUM
admet-2753	166	27	prisma	prisma	NOUN
admet-2753	166	28	buffer	buffer	NOUN
admet-2753	166	29	,	,	PUNCT
admet-2753	166	30	37	37	NUM
admet-2753	166	31	°	°	NUM
admet-2753	166	32	c	c	NOUN
admet-2753	166	33	based	base	VERB
admet-2753	166	34	on	on	ADP
admet-2753	166	35	the	the	DET
admet-2753	166	36	thermograms	thermogram	NOUN
admet-2753	166	37	obtained	obtain	VERB
admet-2753	166	38	from	from	ADP
admet-2753	166	39	the	the	DET
admet-2753	166	40	differential	differential	NOUN
admet-2753	166	41	scanning	scan	VERB
admet-2753	166	42	calorimetry	calorimetry	NOUN
admet-2753	166	43	(	(	PUNCT
admet-2753	166	44	dsc	dsc	NOUN
admet-2753	166	45	)	)	PUNCT
admet-2753	166	46	measurements	measurement	NOUN
admet-2753	166	47	of	of	ADP
admet-2753	166	48	the	the	DET
admet-2753	166	49	solid	solid	ADJ
admet-2753	166	50	excess	excess	NOUN
admet-2753	166	51	(	(	PUNCT
admet-2753	166	52	see	see	VERB
admet-2753	166	53	supporting	support	VERB
admet-2753	166	54	information	information	NOUN
admet-2753	166	55	,	,	PUNCT
admet-2753	166	56	figure	figure	NOUN
admet-2753	166	57	s1	s1	NOUN
admet-2753	166	58	)	)	PUNCT
admet-2753	167	1	,	,	PUNCT
admet-2753	167	2	we	we	PRON
admet-2753	167	3	can	can	AUX
admet-2753	167	4	conclude	conclude	VERB
admet-2753	167	5	that	that	SCONJ
admet-2753	167	6	the	the	DET
admet-2753	167	7	melting	melting	NOUN
admet-2753	167	8	point	point	NOUN
admet-2753	167	9	of	of	ADP
admet-2753	167	10	the	the	DET
admet-2753	167	11	samples	sample	NOUN
admet-2753	167	12	taken	take	VERB
admet-2753	167	13	after	after	ADP
admet-2753	167	14	the	the	DET
admet-2753	167	15	equilibrium	equilibrium	NOUN
admet-2753	167	16	solubility	solubility	NOUN
admet-2753	167	17	measurement	measurement	NOUN
admet-2753	167	18	is	be	AUX
admet-2753	167	19	the	the	DET
admet-2753	167	20	same	same	ADJ
admet-2753	167	21	as	as	ADP
admet-2753	167	22	that	that	PRON
admet-2753	167	23	of	of	ADP
admet-2753	167	24	the	the	DET
admet-2753	167	25	corresponding	corresponding	ADJ
admet-2753	167	26	reference	reference	NOUN
admet-2753	167	27	materials	material	NOUN
admet-2753	167	28	.	.	PUNCT
admet-2753	168	1	there	there	PRON
admet-2753	168	2	is	be	VERB
admet-2753	168	3	no	no	DET
admet-2753	168	4	difference	difference	NOUN
admet-2753	168	5	between	between	ADP
admet-2753	168	6	the	the	DET
admet-2753	168	7	raman	raman	NOUN
admet-2753	168	8	spectra	spectra	NOUN
admet-2753	168	9	(	(	PUNCT
admet-2753	168	10	see	see	VERB
admet-2753	168	11	supporting	support	VERB
admet-2753	168	12	information	information	NOUN
admet-2753	168	13	figure	figure	NOUN
admet-2753	168	14	s2	s2	PROPN
admet-2753	168	15	)	)	PUNCT
admet-2753	168	16	of	of	ADP
admet-2753	168	17	the	the	DET
admet-2753	168	18	sample	sample	NOUN
admet-2753	168	19	and	and	CCONJ
admet-2753	168	20	the	the	DET
admet-2753	168	21	reference	reference	NOUN
admet-2753	168	22	materials	material	NOUN
admet-2753	168	23	.	.	PUNCT
admet-2753	169	1	thus	thus	ADV
admet-2753	169	2	,	,	PUNCT
admet-2753	169	3	it	it	PRON
admet-2753	169	4	can	can	AUX
admet-2753	169	5	be	be	AUX
admet-2753	169	6	concluded	conclude	VERB
admet-2753	169	7	that	that	SCONJ
admet-2753	169	8	both	both	DET
admet-2753	169	9	polymorphic	polymorphic	ADJ
admet-2753	169	10	modifications	modification	NOUN
admet-2753	169	11	(	(	PUNCT
admet-2753	169	12	form	form	NOUN
admet-2753	169	13	i	i	PRON
admet-2753	169	14	and	and	CCONJ
admet-2753	169	15	form	form	PROPN
admet-2753	169	16	ii	ii	PROPN
admet-2753	169	17	)	)	PUNCT
admet-2753	169	18	of	of	ADP
admet-2753	169	19	carvedilol	carvedilol	NOUN
admet-2753	169	20	were	be	AUX
admet-2753	169	21	sufficiently	sufficiently	ADV
admet-2753	169	22	stable	stable	ADJ
admet-2753	169	23	under	under	ADP
admet-2753	169	24	the	the	DET
admet-2753	169	25	measurement	measurement	NOUN
admet-2753	169	26	conditions	condition	NOUN
admet-2753	169	27	and	and	CCONJ
admet-2753	169	28	no	no	DET
admet-2753	169	29	solventmediated	solventmediate	VERB
admet-2753	169	30	polymorphic	polymorphic	ADJ
admet-2753	169	31	transformation	transformation	NOUN
admet-2753	169	32	or	or	CCONJ
admet-2753	169	33	amorphisation	amorphisation	NOUN
admet-2753	169	34	occurred	occur	VERB
admet-2753	169	35	.	.	PUNCT
admet-2753	170	1	c	c	VERB
admet-2753	170	2	a	a	DET
admet-2753	170	3	r	r	NOUN
admet-2753	170	4	s	s	NOUN
admet-2753	171	1	o	o	NOUN
admet-2753	171	2	lu	lu	PROPN
admet-2753	171	3	b	b	PROPN
admet-2753	171	4	il	il	PROPN
admet-2753	171	5	it	it	PRON
admet-2753	171	6	y	y	INTJ
admet-2753	171	7	,	,	PUNCT
admet-2753	171	8	m	m	VERB
admet-2753	171	9	m	m	VERB
admet-2753	171	10	p	p	NOUN
admet-2753	171	11	ap	ap	PROPN
admet-2753	171	12	p	p	PROPN
admet-2753	171	13	/	/	SYM
admet-2753	171	14	c	c	NOUN
admet-2753	171	15	m	m	NOUN
admet-2753	171	16	s	s	NOUN
admet-2753	171	17	-1	-1	PROPN
admet-2753	172	1	p	p	X
admet-2753	172	2	ap	ap	PROPN
admet-2753	173	1	p	p	PROPN
admet-2753	173	2	/	/	SYM
admet-2753	173	3	c	c	NOUN
admet-2753	173	4	m	m	NOUN
admet-2753	173	5	s	s	NOUN
admet-2753	173	6	-1	-1	PROPN
admet-2753	173	7	p	p	X
admet-2753	174	1	ap	ap	PROPN
admet-2753	174	2	p	p	PROPN
admet-2753	174	3	/	/	SYM
admet-2753	174	4	c	c	NOUN
admet-2753	174	5	m	m	NOUN
admet-2753	174	6	s	s	NOUN
admet-2753	174	7	-1	-1	NOUN
admet-2753	174	8	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	174	9	p.	p.	PROPN
admet-2753	174	10	tőzsér	tőzsér	PROPN
admet-2753	174	11	et	et	PROPN
admet-2753	174	12	al	al	PROPN
admet-2753	174	13	.	.	PROPN
admet-2753	174	14	admet	admet	PROPN
admet-2753	174	15	&	&	CCONJ
admet-2753	174	16	dmpk	dmpk	PROPN
admet-2753	174	17	13(4	13(4	NUM
admet-2753	174	18	)	)	PUNCT
admet-2753	174	19	(	(	PUNCT
admet-2753	174	20	2025	2025	NUM
admet-2753	174	21	)	)	PUNCT
admet-2753	174	22	2753	2753	NUM
admet-2753	174	23	10	10	NUM
admet-2753	174	24	assuming	assume	VERB
admet-2753	174	25	a	a	DET
admet-2753	174	26	1:1	1:1	NUM
admet-2753	174	27	complexation	complexation	NOUN
admet-2753	174	28	,	,	PUNCT
admet-2753	174	29	the	the	DET
admet-2753	174	30	equilibrium	equilibrium	NOUN
admet-2753	174	31	constant	constant	ADJ
admet-2753	174	32	of	of	ADP
admet-2753	174	33	the	the	DET
admet-2753	174	34	complex	complex	ADJ
admet-2753	174	35	(	(	PUNCT
admet-2753	174	36	k1:1	k1:1	PROPN
admet-2753	174	37	)	)	PUNCT
admet-2753	174	38	and	and	CCONJ
admet-2753	174	39	the	the	DET
admet-2753	174	40	complexation	complexation	NOUN
admet-2753	174	41	efficiency	efficiency	NOUN
admet-2753	174	42	(	(	PUNCT
admet-2753	174	43	ce	ce	PROPN
admet-2753	174	44	)	)	PUNCT
admet-2753	174	45	were	be	AUX
admet-2753	174	46	determined	determine	VERB
admet-2753	174	47	based	base	VERB
admet-2753	174	48	on	on	ADP
admet-2753	174	49	the	the	DET
admet-2753	174	50	solubility	solubility	NOUN
admet-2753	174	51	of	of	ADP
admet-2753	174	52	the	the	DET
admet-2753	174	53	pure	pure	ADJ
admet-2753	174	54	active	active	ADJ
admet-2753	174	55	compound	compound	NOUN
admet-2753	174	56	(	(	PUNCT
admet-2753	174	57	s0	s0	PROPN
admet-2753	174	58	)	)	PUNCT
admet-2753	174	59	and	and	CCONJ
admet-2753	174	60	the	the	DET
admet-2753	174	61	slope	slope	NOUN
admet-2753	174	62	of	of	ADP
admet-2753	174	63	the	the	DET
admet-2753	174	64	lines	line	NOUN
admet-2753	174	65	(	(	PUNCT
admet-2753	174	66	table	table	NOUN
admet-2753	174	67	3	3	NUM
admet-2753	174	68	)	)	PUNCT
admet-2753	174	69	.	.	PUNCT
admet-2753	175	1	table	table	NOUN
admet-2753	175	2	3	3	NUM
admet-2753	175	3	.	.	PUNCT
admet-2753	175	4	complex	complex	ADJ
admet-2753	175	5	stability	stability	NOUN
admet-2753	175	6	constant	constant	ADJ
admet-2753	175	7	(	(	PUNCT
admet-2753	175	8	k1:1	k1:1	PROPN
admet-2753	175	9	)	)	PUNCT
admet-2753	175	10	and	and	CCONJ
admet-2753	175	11	complexation	complexation	NOUN
admet-2753	175	12	efficiency	efficiency	NOUN
admet-2753	175	13	(	(	PUNCT
admet-2753	175	14	ce	ce	PROPN
admet-2753	175	15	)	)	PUNCT
admet-2753	175	16	of	of	ADP
admet-2753	175	17	carhp	carhp	PROPN
admet-2753	175	18	-	-	PUNCT
admet-2753	175	19	β	β	NOUN
admet-2753	175	20	-	-	ADJ
admet-2753	175	21	cd	cd	ADJ
admet-2753	175	22	complex	complex	NOUN
admet-2753	175	23	in	in	ADP
admet-2753	175	24	ph	ph	PROPN
admet-2753	175	25	10	10	NUM
admet-2753	175	26	prisma	prisma	NOUN
admet-2753	175	27	buffer	buffer	NOUN
admet-2753	175	28	,	,	PUNCT
admet-2753	175	29	37	37	NUM
admet-2753	175	30	°	°	NOUN
admet-2753	175	31	c	c	NOUN
admet-2753	175	32	car	car	NOUN
admet-2753	175	33	polymorph	polymorph	NOUN
admet-2753	175	34	s0	s0	PROPN
admet-2753	175	35	/	/	SYM
admet-2753	175	36	m	m	PROPN
admet-2753	175	37	slope	slope	NOUN
admet-2753	175	38	k1:1	k1:1	PROPN
admet-2753	175	39	/	/	SYM
admet-2753	175	40	m-1	m-1	PROPN
admet-2753	175	41	ce	ce	PROPN
admet-2753	175	42	form	form	NOUN
admet-2753	175	43	i	i	PRON
admet-2753	175	44	5.412	5.412	NUM
admet-2753	175	45	9.64510	9.64510	NUM
admet-2753	175	46	-	-	SYM
admet-2753	175	47	4	4	NUM
admet-2753	175	48	178.4	178.4	NUM
admet-2753	175	49	0.965410	0.965410	NUM
admet-2753	175	50	-	-	SYM
admet-2753	175	51	3	3	NUM
admet-2753	175	52	form	form	NOUN
admet-2753	175	53	ii	ii	NOUN
admet-2753	175	54	7.627	7.627	NUM
admet-2753	175	55	1.93410	1.93410	NUM
admet-2753	175	56	-	-	SYM
admet-2753	175	57	3	3	NUM
admet-2753	175	58	254.1	254.1	NUM
admet-2753	175	59	1.93810	1.93810	NUM
admet-2753	175	60	-	-	SYM
admet-2753	175	61	3	3	NUM
admet-2753	175	62	the	the	DET
admet-2753	175	63	effect	effect	NOUN
admet-2753	175	64	of	of	ADP
admet-2753	175	65	the	the	DET
admet-2753	175	66	solid	solid	ADJ
admet-2753	175	67	phase	phase	NOUN
admet-2753	175	68	is	be	AUX
admet-2753	175	69	also	also	ADV
admet-2753	175	70	responsible	responsible	ADJ
admet-2753	175	71	for	for	ADP
admet-2753	175	72	the	the	DET
admet-2753	175	73	difference	difference	NOUN
admet-2753	175	74	in	in	ADP
admet-2753	175	75	the	the	DET
admet-2753	175	76	efficiency	efficiency	NOUN
admet-2753	175	77	of	of	ADP
admet-2753	175	78	the	the	DET
admet-2753	175	79	complexation	complexation	NOUN
admet-2753	175	80	of	of	ADP
admet-2753	175	81	form	form	NOUN
admet-2753	176	1	i	i	PRON
admet-2753	176	2	and	and	CCONJ
admet-2753	176	3	form	form	VERB
admet-2753	176	4	ii	ii	PROPN
admet-2753	176	5	modifications	modification	NOUN
admet-2753	176	6	.	.	PUNCT
admet-2753	177	1	in	in	ADP
admet-2753	177	2	the	the	DET
admet-2753	177	3	equilibrium	equilibrium	NOUN
admet-2753	177	4	solubility	solubility	NOUN
admet-2753	177	5	measurements	measurement	NOUN
admet-2753	177	6	,	,	PUNCT
admet-2753	177	7	it	it	PRON
admet-2753	177	8	was	be	AUX
admet-2753	177	9	found	find	VERB
admet-2753	177	10	that	that	SCONJ
admet-2753	177	11	the	the	DET
admet-2753	177	12	thermodynamically	thermodynamically	ADV
admet-2753	177	13	stable	stable	ADJ
admet-2753	177	14	form	form	NOUN
admet-2753	177	15	i	i	PRON
admet-2753	177	16	has	have	VERB
admet-2753	177	17	a	a	DET
admet-2753	177	18	lower	low	ADJ
admet-2753	177	19	solubility	solubility	NOUN
admet-2753	177	20	than	than	ADP
admet-2753	177	21	form	form	NOUN
admet-2753	177	22	ii	ii	NOUN
admet-2753	177	23	,	,	PUNCT
admet-2753	177	24	and	and	CCONJ
admet-2753	177	25	accordingly	accordingly	ADV
admet-2753	177	26	,	,	PUNCT
admet-2753	177	27	the	the	DET
admet-2753	177	28	complexation	complexation	NOUN
admet-2753	177	29	efficiency	efficiency	NOUN
admet-2753	177	30	is	be	AUX
admet-2753	177	31	lower	low	ADJ
admet-2753	177	32	in	in	ADP
admet-2753	177	33	the	the	DET
admet-2753	177	34	presence	presence	NOUN
admet-2753	177	35	of	of	ADP
admet-2753	177	36	the	the	DET
admet-2753	177	37	more	more	ADV
admet-2753	177	38	stable	stable	ADJ
admet-2753	177	39	form	form	NOUN
admet-2753	177	40	.	.	PUNCT
admet-2753	178	1	from	from	ADP
admet-2753	178	2	the	the	DET
admet-2753	178	3	results	result	NOUN
admet-2753	178	4	obtained	obtain	VERB
admet-2753	178	5	in	in	ADP
admet-2753	178	6	the	the	DET
admet-2753	178	7	phase	phase	NOUN
admet-2753	178	8	-	-	PUNCT
admet-2753	178	9	solubility	solubility	NOUN
admet-2753	178	10	measurement	measurement	NOUN
admet-2753	178	11	(	(	PUNCT
admet-2753	178	12	figure	figure	NOUN
admet-2753	178	13	3	3	NUM
admet-2753	178	14	and	and	CCONJ
admet-2753	178	15	table	table	NOUN
admet-2753	178	16	34	34	NUM
admet-2753	178	17	)	)	PUNCT
admet-2753	178	18	,	,	PUNCT
admet-2753	178	19	it	it	PRON
admet-2753	178	20	can	can	AUX
admet-2753	178	21	be	be	AUX
admet-2753	178	22	concluded	conclude	VERB
admet-2753	178	23	that	that	SCONJ
admet-2753	178	24	hp	hp	PROPN
admet-2753	178	25	-	-	PUNCT
admet-2753	178	26	β	β	NOUN
admet-2753	178	27	-	-	NOUN
admet-2753	178	28	cd	cd	NOUN
admet-2753	178	29	forms	form	NOUN
admet-2753	178	30	a	a	DET
admet-2753	178	31	rather	rather	ADV
admet-2753	178	32	stable	stable	ADJ
admet-2753	178	33	1:1	1:1	NUM
admet-2753	178	34	stoichiometric	stoichiometric	NOUN
admet-2753	178	35	complex	complex	NOUN
admet-2753	178	36	with	with	ADP
admet-2753	178	37	the	the	DET
admet-2753	178	38	model	model	NOUN
admet-2753	178	39	api	api	NOUN
admet-2753	178	40	;	;	PUNCT
admet-2753	178	41	therefore	therefore	ADV
admet-2753	178	42	,	,	PUNCT
admet-2753	178	43	hpβ	hpβ	PROPN
admet-2753	178	44	-	-	PUNCT
admet-2753	178	45	cd	cd	PROPN
admet-2753	178	46	was	be	AUX
admet-2753	178	47	chosen	choose	VERB
admet-2753	178	48	as	as	ADP
admet-2753	178	49	a	a	DET
admet-2753	178	50	model	model	NOUN
admet-2753	178	51	solubilizing	solubilize	VERB
admet-2753	178	52	additive	additive	NOUN
admet-2753	178	53	with	with	ADP
admet-2753	178	54	known	know	VERB
admet-2753	178	55	hydrodynamic	hydrodynamic	ADJ
admet-2753	178	56	size	size	NOUN
admet-2753	178	57	[	[	X
admet-2753	178	58	56	56	NUM
admet-2753	178	59	]	]	X
admet-2753	178	60	(	(	PUNCT
admet-2753	178	61	1	1	NUM
admet-2753	178	62	-	-	SYM
admet-2753	178	63	2	2	NUM
admet-2753	178	64	nm	nm	NOUN
admet-2753	178	65	)	)	PUNCT
admet-2753	178	66	for	for	ADP
admet-2753	178	67	the	the	DET
admet-2753	178	68	in	in	ADV
admet-2753	178	69	vitro	vitro	X
admet-2753	178	70	side	side	NOUN
admet-2753	178	71	-	-	PUNCT
admet-2753	178	72	by	by	ADP
admet-2753	178	73	-	-	PUNCT
admet-2753	178	74	side	side	NOUN
admet-2753	178	75	diffusion	diffusion	NOUN
admet-2753	178	76	cell	cell	NOUN
admet-2753	178	77	assays	assay	NOUN
admet-2753	178	78	,	,	PUNCT
admet-2753	178	79	including	include	VERB
admet-2753	178	80	size	size	NOUN
admet-2753	178	81	-	-	PUNCT
admet-2753	178	82	exclusion	exclusion	NOUN
admet-2753	178	83	membranes	membrane	NOUN
admet-2753	178	84	.	.	PUNCT
admet-2753	179	1	since	since	SCONJ
admet-2753	179	2	the	the	DET
admet-2753	179	3	phase	phase	NOUN
admet-2753	179	4	-	-	PUNCT
admet-2753	179	5	solubility	solubility	NOUN
admet-2753	179	6	diagram	diagram	NOUN
admet-2753	179	7	showed	show	VERB
admet-2753	179	8	a	a	DET
admet-2753	179	9	linear	linear	ADJ
admet-2753	179	10	relationship	relationship	NOUN
admet-2753	179	11	between	between	ADP
admet-2753	179	12	the	the	DET
admet-2753	179	13	hp	hp	PROPN
admet-2753	179	14	-	-	PUNCT
admet-2753	179	15	β	β	NOUN
admet-2753	179	16	-	-	ADJ
admet-2753	179	17	cd	cd	ADJ
admet-2753	179	18	concentration	concentration	NOUN
admet-2753	179	19	and	and	CCONJ
admet-2753	179	20	car	car	NOUN
admet-2753	179	21	solubility	solubility	NOUN
admet-2753	179	22	,	,	PUNCT
admet-2753	179	23	the	the	DET
admet-2753	179	24	concentration	concentration	NOUN
admet-2753	179	25	of	of	ADP
admet-2753	179	26	the	the	DET
admet-2753	179	27	solubilizing	solubilize	VERB
admet-2753	179	28	additive	additive	NOUN
admet-2753	179	29	was	be	AUX
admet-2753	179	30	chosen	choose	VERB
admet-2753	179	31	based	base	VERB
admet-2753	179	32	on	on	ADP
admet-2753	179	33	a	a	DET
admet-2753	179	34	known	know	VERB
admet-2753	179	35	hp	hp	NOUN
admet-2753	179	36	-	-	PUNCT
admet-2753	179	37	β	β	NOUN
admet-2753	179	38	-	-	NOUN
admet-2753	179	39	cd	cd	NOUN
admet-2753	179	40	containing	contain	VERB
admet-2753	179	41	marketed	market	VERB
admet-2753	179	42	solution	solution	NOUN
admet-2753	179	43	[	[	X
admet-2753	179	44	57	57	NUM
admet-2753	179	45	]	]	PUNCT
admet-2753	179	46	and	and	CCONJ
admet-2753	179	47	the	the	DET
admet-2753	179	48	recommendation	recommendation	NOUN
admet-2753	179	49	to	to	PART
admet-2753	179	50	take	take	VERB
admet-2753	179	51	the	the	DET
admet-2753	179	52	solution	solution	NOUN
admet-2753	179	53	with	with	ADP
admet-2753	179	54	a	a	DET
admet-2753	179	55	glass	glass	NOUN
admet-2753	179	56	of	of	ADP
admet-2753	179	57	water	water	NOUN
admet-2753	179	58	.	.	PUNCT
admet-2753	180	1	the	the	DET
admet-2753	180	2	thermodynamic	thermodynamic	ADJ
admet-2753	180	3	solubility	solubility	NOUN
admet-2753	180	4	results	result	VERB
admet-2753	180	5	with	with	ADP
admet-2753	180	6	the	the	DET
admet-2753	180	7	chosen	choose	VERB
admet-2753	180	8	15	15	NUM
admet-2753	180	9	mg	mg	PROPN
admet-2753	180	10	ml-1	ml-1	PRON
admet-2753	180	11	hp	hp	PROPN
admet-2753	180	12	-	-	PUNCT
admet-2753	180	13	β	β	NOUN
admet-2753	180	14	-	-	ADJ
admet-2753	180	15	cd	cd	ADJ
admet-2753	180	16	concentration	concentration	NOUN
admet-2753	180	17	are	be	AUX
admet-2753	180	18	presented	present	VERB
admet-2753	180	19	in	in	ADP
admet-2753	180	20	table	table	NOUN
admet-2753	180	21	4	4	NUM
admet-2753	180	22	.	.	PUNCT
admet-2753	180	23	table	table	NOUN
admet-2753	180	24	4	4	NUM
admet-2753	180	25	.	.	PUNCT
admet-2753	180	26	thermodynamic	thermodynamic	ADJ
admet-2753	180	27	solubility	solubility	NOUN
admet-2753	180	28	of	of	ADP
admet-2753	180	29	car	car	NOUN
admet-2753	180	30	polymorphs	polymorph	NOUN
admet-2753	180	31	in	in	ADP
admet-2753	180	32	ph	ph	ADJ
admet-2753	180	33	10	10	NUM
admet-2753	180	34	prisma	prisma	NOUN
admet-2753	180	35	buffer	buffer	NOUN
admet-2753	180	36	with	with	ADP
admet-2753	180	37	and	and	CCONJ
admet-2753	180	38	without	without	ADP
admet-2753	180	39	the	the	DET
admet-2753	180	40	addition	addition	NOUN
admet-2753	180	41	of	of	ADP
admet-2753	180	42	15	15	NUM
admet-2753	180	43	mg	mg	NOUN
admet-2753	180	44	ml-1	ml-1	PRON
admet-2753	180	45	hp	hp	PROPN
admet-2753	180	46	-	-	PUNCT
admet-2753	180	47	β	β	NOUN
admet-2753	180	48	-	-	NOUN
admet-2753	180	49	cd	cd	NOUN
admet-2753	180	50	,	,	PUNCT
admet-2753	180	51	37	37	NUM
admet-2753	180	52	°	°	NUM
admet-2753	180	53	c	c	NOUN
admet-2753	180	54	form	form	NOUN
admet-2753	180	55	i	i	PRON
admet-2753	180	56	form	form	VERB
admet-2753	180	57	i	i	PRON
admet-2753	180	58	+	+	CCONJ
admet-2753	180	59	hp	hp	PROPN
admet-2753	180	60	-	-	PUNCT
admet-2753	180	61	β	β	NOUN
admet-2753	180	62	-	-	ADJ
admet-2753	180	63	cd	cd	ADJ
admet-2753	180	64	form	form	NOUN
admet-2753	180	65	ii	ii	PROPN
admet-2753	180	66	form	form	PROPN
admet-2753	180	67	ii	ii	PROPN
admet-2753	180	68	+	+	CCONJ
admet-2753	180	69	hp	hp	PROPN
admet-2753	180	70	-	-	PUNCT
admet-2753	180	71	β	β	NOUN
admet-2753	180	72	-	-	ADJ
admet-2753	180	73	cd	cd	ADJ
admet-2753	180	74	equilibrium	equilibrium	NOUN
admet-2753	180	75	thermodynamic	thermodynamic	ADJ
admet-2753	180	76	solubility	solubility	PROPN
admet-2753	181	1	μg	μg	PROPN
admet-2753	181	2	ml-1	ml-1	ADV
admet-2753	181	3	2.15	2.15	NUM
admet-2753	181	4	±0.23	±0.23	PROPN
admet-2753	181	5	6.69	6.69	NUM
admet-2753	181	6	±0.54	±0.54	PROPN
admet-2753	181	7	3.37	3.37	NUM
admet-2753	181	8	±0.21	±0.21	PROPN
admet-2753	181	9	10.64	10.64	NUM
admet-2753	181	10	±0.87	±0.87	PROPN
admet-2753	181	11	from	from	ADP
admet-2753	181	12	the	the	DET
admet-2753	181	13	results	result	NOUN
admet-2753	181	14	obtained	obtain	VERB
admet-2753	181	15	in	in	ADP
admet-2753	181	16	the	the	DET
admet-2753	181	17	thermodynamic	thermodynamic	ADJ
admet-2753	181	18	solubility	solubility	NOUN
admet-2753	181	19	measurement	measurement	NOUN
admet-2753	181	20	,	,	PUNCT
admet-2753	181	21	the	the	DET
admet-2753	181	22	solubility	solubility	NOUN
admet-2753	181	23	of	of	ADP
admet-2753	181	24	both	both	DET
admet-2753	181	25	polymorphs	polymorphs	NOUN
admet-2753	181	26	is	be	AUX
admet-2753	181	27	about	about	ADV
admet-2753	181	28	three	three	NUM
admet-2753	181	29	times	time	NOUN
admet-2753	181	30	higher	high	ADJ
admet-2753	181	31	in	in	ADP
admet-2753	181	32	the	the	DET
admet-2753	181	33	presence	presence	NOUN
admet-2753	181	34	of	of	ADP
admet-2753	181	35	15	15	NUM
admet-2753	181	36	mg	mg	NOUN
admet-2753	181	37	ml-1	ml-1	PRON
admet-2753	181	38	hp	hp	PROPN
admet-2753	181	39	-	-	PUNCT
admet-2753	181	40	β	β	NOUN
admet-2753	181	41	-	-	NOUN
admet-2753	181	42	cd	cd	ADJ
admet-2753	181	43	(	(	PUNCT
admet-2753	181	44	table	table	NOUN
admet-2753	181	45	4	4	NUM
admet-2753	181	46	)	)	PUNCT
admet-2753	181	47	.	.	PUNCT
admet-2753	182	1	membrane	membrane	NOUN
admet-2753	182	2	transport	transport	NOUN
admet-2753	182	3	of	of	ADP
admet-2753	182	4	hp--cd	hp--cd	NOUN
admet-2753	182	5	to	to	PART
admet-2753	182	6	investigate	investigate	VERB
admet-2753	182	7	how	how	SCONJ
admet-2753	182	8	stable	stable	ADJ
admet-2753	182	9	the	the	DET
admet-2753	182	10	lipophilic	lipophilic	ADJ
admet-2753	182	11	membrane	membrane	NOUN
admet-2753	182	12	is	be	AUX
admet-2753	182	13	in	in	ADP
admet-2753	182	14	the	the	DET
admet-2753	182	15	presence	presence	NOUN
admet-2753	182	16	of	of	ADP
admet-2753	182	17	15	15	NUM
admet-2753	182	18	mg	mg	NOUN
admet-2753	182	19	ml-1	ml-1	PRON
admet-2753	182	20	hp	hp	PROPN
admet-2753	182	21	-	-	PUNCT
admet-2753	182	22	β	β	NOUN
admet-2753	182	23	-	-	NOUN
admet-2753	182	24	cd	cd	NOUN
admet-2753	182	25	in	in	ADP
admet-2753	182	26	the	the	DET
admet-2753	182	27	donor	donor	NOUN
admet-2753	182	28	compartment	compartment	NOUN
admet-2753	182	29	and	and	CCONJ
admet-2753	182	30	whether	whether	SCONJ
admet-2753	182	31	hp	hp	VERB
admet-2753	182	32	-	-	PUNCT
admet-2753	182	33	β	β	NOUN
admet-2753	182	34	-	-	NOUN
admet-2753	182	35	cd	cd	NOUN
admet-2753	182	36	can	can	AUX
admet-2753	182	37	permeate	permeate	VERB
admet-2753	182	38	the	the	DET
admet-2753	182	39	size	size	NOUN
admet-2753	182	40	-	-	PUNCT
admet-2753	182	41	exclusion	exclusion	NOUN
admet-2753	182	42	membrane	membrane	NOUN
admet-2753	182	43	,	,	PUNCT
admet-2753	182	44	in	in	ADP
admet-2753	182	45	vitro	vitro	X
admet-2753	182	46	side	side	NOUN
admet-2753	182	47	-	-	PUNCT
admet-2753	182	48	by	by	ADP
admet-2753	182	49	-	-	PUNCT
admet-2753	182	50	side	side	NOUN
admet-2753	182	51	diffusion	diffusion	NOUN
admet-2753	182	52	cell	cell	NOUN
admet-2753	182	53	assays	assay	NOUN
admet-2753	182	54	were	be	AUX
admet-2753	182	55	carried	carry	VERB
admet-2753	182	56	out	out	ADP
admet-2753	182	57	with	with	ADP
admet-2753	182	58	the	the	DET
admet-2753	182	59	solubilizing	solubilize	VERB
admet-2753	182	60	agent	agent	NOUN
admet-2753	182	61	and	and	CCONJ
admet-2753	182	62	hp	hp	PROPN
admet-2753	182	63	-	-	PUNCT
admet-2753	182	64	β	β	NOUN
admet-2753	182	65	-	-	ADJ
admet-2753	182	66	cd	cd	ADJ
admet-2753	182	67	concentration	concentration	NOUN
admet-2753	182	68	was	be	AUX
admet-2753	182	69	detected	detect	VERB
admet-2753	182	70	on	on	ADP
admet-2753	182	71	the	the	DET
admet-2753	182	72	acceptor	acceptor	NOUN
admet-2753	182	73	side	side	NOUN
admet-2753	182	74	of	of	ADP
admet-2753	182	75	the	the	DET
admet-2753	182	76	different	different	ADJ
admet-2753	182	77	membranes	membrane	NOUN
admet-2753	182	78	.	.	PUNCT
admet-2753	183	1	hp	hp	PROPN
admet-2753	183	2	-	-	PUNCT
admet-2753	183	3	β	β	NOUN
admet-2753	183	4	-	-	NOUN
admet-2753	183	5	cd	cd	PROPN
admet-2753	183	6	was	be	AUX
admet-2753	183	7	detected	detect	VERB
admet-2753	183	8	under	under	ADP
admet-2753	183	9	the	the	DET
admet-2753	183	10	lod	lod	NOUN
admet-2753	183	11	in	in	ADP
admet-2753	183	12	the	the	DET
admet-2753	183	13	acceptor	acceptor	NOUN
admet-2753	183	14	compartment	compartment	NOUN
admet-2753	183	15	in	in	ADP
admet-2753	183	16	the	the	DET
admet-2753	183	17	case	case	NOUN
admet-2753	183	18	of	of	ADP
admet-2753	183	19	the	the	DET
admet-2753	183	20	lipophilic	lipophilic	ADJ
admet-2753	183	21	membrane	membrane	NOUN
admet-2753	183	22	,	,	PUNCT
admet-2753	183	23	so	so	SCONJ
admet-2753	183	24	it	it	PRON
admet-2753	183	25	can	can	AUX
admet-2753	183	26	be	be	AUX
admet-2753	183	27	concluded	conclude	VERB
admet-2753	183	28	that	that	SCONJ
admet-2753	183	29	cd	cd	PROPN
admet-2753	183	30	does	do	AUX
admet-2753	183	31	not	not	PART
admet-2753	183	32	cause	cause	VERB
admet-2753	183	33	significant	significant	ADJ
admet-2753	183	34	structural	structural	ADJ
admet-2753	183	35	damage	damage	NOUN
admet-2753	183	36	in	in	ADP
admet-2753	183	37	the	the	DET
admet-2753	183	38	lipophilic	lipophilic	ADJ
admet-2753	183	39	layer	layer	NOUN
admet-2753	183	40	for	for	ADP
admet-2753	183	41	8	8	NUM
admet-2753	183	42	hours	hour	NOUN
admet-2753	183	43	(	(	PUNCT
admet-2753	183	44	figure	figure	NOUN
admet-2753	183	45	5	5	NUM
admet-2753	183	46	)	)	PUNCT
admet-2753	183	47	.	.	PUNCT
admet-2753	184	1	the	the	DET
admet-2753	184	2	cd	cd	PROPN
admet-2753	184	3	is	be	AUX
admet-2753	184	4	detected	detect	VERB
admet-2753	184	5	increasingly	increasingly	ADV
admet-2753	184	6	on	on	ADP
admet-2753	184	7	the	the	DET
admet-2753	184	8	acceptor	acceptor	NOUN
admet-2753	184	9	side	side	NOUN
admet-2753	184	10	,	,	PUNCT
admet-2753	184	11	reaching	reach	VERB
admet-2753	184	12	516	516	NUM
admet-2753	184	13	μg	μg	NOUN
admet-2753	184	14	ml-1	ml-1	PRON
admet-2753	184	15	concentration	concentration	NOUN
admet-2753	184	16	in	in	ADP
admet-2753	184	17	8	8	NUM
admet-2753	184	18	hours	hour	NOUN
admet-2753	184	19	in	in	ADP
admet-2753	184	20	the	the	DET
admet-2753	184	21	case	case	NOUN
admet-2753	184	22	of	of	ADP
admet-2753	184	23	a	a	DET
admet-2753	184	24	6	6	NUM
admet-2753	184	25	kda	kda	NOUN
admet-2753	184	26	size	size	NOUN
admet-2753	184	27	-	-	PUNCT
admet-2753	184	28	exclusion	exclusion	NOUN
admet-2753	184	29	membrane	membrane	NOUN
admet-2753	184	30	(	(	PUNCT
admet-2753	184	31	meaning	mean	VERB
admet-2753	184	32	1.075	1.075	NUM
admet-2753	184	33	g	g	PROPN
admet-2753	184	34	cm-2	cm-2	NOUN
admet-2753	184	35	min-1	min-1	X
admet-2753	184	36	flux	flux	PROPN
admet-2753	184	37	value	value	NOUN
admet-2753	184	38	)	)	PUNCT
admet-2753	184	39	and	and	CCONJ
admet-2753	184	40	377	377	NUM
admet-2753	184	41	μg	μg	NOUN
admet-2753	184	42	ml-1	ml-1	PRON
admet-2753	184	43	concentration	concentration	NOUN
admet-2753	184	44	in	in	ADP
admet-2753	184	45	the	the	DET
admet-2753	184	46	case	case	NOUN
admet-2753	184	47	of	of	ADP
admet-2753	184	48	a	a	DET
admet-2753	184	49	1	1	NUM
admet-2753	184	50	kda	kda	NOUN
admet-2753	184	51	sizeexclusion	sizeexclusion	NOUN
admet-2753	184	52	membrane	membrane	NOUN
admet-2753	184	53	(	(	PUNCT
admet-2753	184	54	meaning	mean	VERB
admet-2753	184	55	0.785	0.785	NUM
admet-2753	184	56	g	g	PROPN
admet-2753	184	57	cm-2	cm-2	NOUN
admet-2753	184	58	min-1	min-1	X
admet-2753	184	59	flux	flux	PROPN
admet-2753	184	60	value	value	NOUN
admet-2753	184	61	)	)	PUNCT
admet-2753	184	62	,	,	PUNCT
admet-2753	184	63	showing	show	VERB
admet-2753	184	64	that	that	SCONJ
admet-2753	184	65	hp	hp	NOUN
admet-2753	184	66	-	-	PUNCT
admet-2753	184	67	β	β	NOUN
admet-2753	184	68	-	-	NOUN
admet-2753	184	69	cd	cd	PROPN
admet-2753	184	70	was	be	AUX
admet-2753	184	71	able	able	ADJ
admet-2753	184	72	to	to	PART
admet-2753	184	73	diffuse	diffuse	VERB
admet-2753	184	74	across	across	ADP
admet-2753	184	75	both	both	DET
admet-2753	184	76	size	size	NOUN
admet-2753	184	77	-	-	PUNCT
admet-2753	184	78	exclusion	exclusion	NOUN
admet-2753	184	79	membranes	membrane	NOUN
admet-2753	184	80	.	.	PUNCT
admet-2753	185	1	based	base	VERB
admet-2753	185	2	on	on	ADP
admet-2753	185	3	the	the	DET
admet-2753	185	4	results	result	NOUN
admet-2753	185	5	,	,	PUNCT
admet-2753	185	6	the	the	DET
admet-2753	185	7	two	two	NUM
admet-2753	185	8	different	different	ADJ
admet-2753	185	9	scenarios	scenario	NOUN
admet-2753	185	10	were	be	AUX
admet-2753	185	11	depicted	depict	VERB
admet-2753	185	12	in	in	ADP
admet-2753	185	13	figure	figure	NOUN
admet-2753	185	14	6	6	NUM
admet-2753	185	15	.	.	PUNCT
admet-2753	186	1	in	in	ADP
admet-2753	186	2	the	the	DET
admet-2753	186	3	case	case	NOUN
admet-2753	186	4	of	of	ADP
admet-2753	186	5	the	the	DET
admet-2753	186	6	lipophilic	lipophilic	ADJ
admet-2753	186	7	membrane	membrane	NOUN
admet-2753	186	8	,	,	PUNCT
admet-2753	186	9	only	only	ADV
admet-2753	186	10	the	the	DET
admet-2753	186	11	drug	drug	NOUN
admet-2753	186	12	is	be	AUX
admet-2753	186	13	able	able	ADJ
admet-2753	186	14	to	to	PART
admet-2753	186	15	permeate	permeate	VERB
admet-2753	186	16	the	the	DET
admet-2753	186	17	membrane	membrane	NOUN
admet-2753	186	18	;	;	PUNCT
admet-2753	186	19	the	the	DET
admet-2753	186	20	solubilizing	solubilize	VERB
admet-2753	186	21	agent	agent	NOUN
admet-2753	186	22	and	and	CCONJ
admet-2753	186	23	the	the	DET
admet-2753	186	24	drug	drug	NOUN
admet-2753	186	25	-	-	PUNCT
admet-2753	186	26	cyclodextrin	cyclodextrin	NOUN
admet-2753	186	27	complex	complex	NOUN
admet-2753	186	28	are	be	AUX
admet-2753	186	29	not	not	PART
admet-2753	186	30	.	.	PUNCT
admet-2753	187	1	in	in	ADP
admet-2753	187	2	the	the	DET
admet-2753	187	3	case	case	NOUN
admet-2753	187	4	of	of	ADP
admet-2753	187	5	the	the	DET
admet-2753	187	6	size	size	NOUN
admet-2753	187	7	-	-	PUNCT
admet-2753	187	8	exclusion	exclusion	NOUN
admet-2753	187	9	membranes	membrane	NOUN
admet-2753	187	10	(	(	PUNCT
admet-2753	187	11	mwco=	mwco=	NUM
admet-2753	187	12	1	1	NUM
admet-2753	187	13	kda	kda	NOUN
admet-2753	187	14	and	and	CCONJ
admet-2753	187	15	6	6	NUM
admet-2753	187	16	kda	kda	NOUN
admet-2753	187	17	)	)	PUNCT
admet-2753	187	18	,	,	PUNCT
admet-2753	187	19	both	both	CCONJ
admet-2753	187	20	the	the	DET
admet-2753	187	21	drug	drug	NOUN
admet-2753	187	22	and	and	CCONJ
admet-2753	187	23	the	the	DET
admet-2753	187	24	hp	hp	PROPN
admet-2753	187	25	-	-	PUNCT
admet-2753	187	26	β	β	NOUN
admet-2753	187	27	-	-	NOUN
admet-2753	187	28	cd	cd	NOUN
admet-2753	187	29	and	and	CCONJ
admet-2753	187	30	their	their	PRON
admet-2753	187	31	complex	complex	NOUN
admet-2753	187	32	are	be	AUX
admet-2753	187	33	able	able	ADJ
admet-2753	187	34	to	to	PART
admet-2753	187	35	go	go	VERB
admet-2753	187	36	through	through	ADV
admet-2753	187	37	.	.	PUNCT
admet-2753	188	1	admet	admet	PROPN
admet-2753	188	2	&	&	CCONJ
admet-2753	188	3	dmpk	dmpk	PROPN
admet-2753	188	4	13(4	13(4	NUM
admet-2753	188	5	)	)	PUNCT
admet-2753	188	6	(	(	PUNCT
admet-2753	188	7	2025	2025	NUM
admet-2753	188	8	)	)	PUNCT
admet-2753	188	9	2753	2753	NUM
admet-2753	188	10	comparison	comparison	NOUN
admet-2753	188	11	of	of	ADP
admet-2753	188	12	lipophilic	lipophilic	ADJ
admet-2753	188	13	and	and	CCONJ
admet-2753	188	14	size	size	NOUN
admet-2753	188	15	-	-	PUNCT
admet-2753	188	16	exclusion	exclusion	NOUN
admet-2753	188	17	membranes	membrane	NOUN
admet-2753	188	18	doi	doi	NOUN
admet-2753	188	19	:	:	PUNCT
admet-2753	188	20	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	188	21	11	11	NUM
admet-2753	188	22	time	time	NOUN
admet-2753	188	23	,	,	PUNCT
admet-2753	188	24	h	h	NOUN
admet-2753	188	25	figure	figure	NOUN
admet-2753	188	26	5	5	NUM
admet-2753	188	27	.	.	PUNCT
admet-2753	188	28	membrane	membrane	NOUN
admet-2753	188	29	transport	transport	NOUN
admet-2753	188	30	of	of	ADP
admet-2753	188	31	hp	hp	PROPN
admet-2753	188	32	-	-	PUNCT
admet-2753	188	33	β	β	NOUN
admet-2753	188	34	-	-	NOUN
admet-2753	188	35	cd	cd	NOUN
admet-2753	188	36	at	at	ADP
admet-2753	188	37	250	250	NUM
admet-2753	188	38	rpm	rpm	NOUN
admet-2753	188	39	and	and	CCONJ
admet-2753	188	40	37	37	NUM
admet-2753	188	41	°	°	NOUN
admet-2753	188	42	c	c	NOUN
admet-2753	188	43	with	with	ADP
admet-2753	188	44	μflux	μflux	NOUN
admet-2753	188	45	apparatus	apparatus	NOUN
admet-2753	188	46	applied	apply	VERB
admet-2753	188	47	lipophilic	lipophilic	ADJ
admet-2753	188	48	membrane	membrane	NOUN
admet-2753	188	49	(	(	PUNCT
admet-2753	188	50	was	be	AUX
admet-2753	188	51	not	not	PART
admet-2753	188	52	detectable	detectable	ADJ
admet-2753	188	53	at	at	ADP
admet-2753	188	54	concentrations	concentration	NOUN
admet-2753	188	55	above	above	ADP
admet-2753	188	56	the	the	DET
admet-2753	188	57	lod	lod	PROPN
admet-2753	188	58	)	)	PUNCT
admet-2753	188	59	,	,	PUNCT
admet-2753	188	60	1	1	NUM
admet-2753	188	61	kda	kda	NOUN
admet-2753	188	62	size	size	NOUN
admet-2753	188	63	-	-	PUNCT
admet-2753	188	64	exclusion	exclusion	NOUN
admet-2753	188	65	membrane	membrane	NOUN
admet-2753	188	66	with	with	ADP
admet-2753	188	67	orange	orange	ADJ
admet-2753	188	68	dots	dot	NOUN
admet-2753	188	69	,	,	PUNCT
admet-2753	188	70	6	6	NUM
admet-2753	188	71	kda	kda	NOUN
admet-2753	188	72	sizeexclusion	sizeexclusion	NOUN
admet-2753	188	73	membrane	membrane	NOUN
admet-2753	188	74	with	with	ADP
admet-2753	188	75	gray	gray	ADJ
admet-2753	188	76	dots	dot	NOUN
admet-2753	188	77	,	,	PUNCT
admet-2753	188	78	(	(	PUNCT
admet-2753	188	79	1.54	1.54	NUM
admet-2753	188	80	cm2	cm2	NOUN
admet-2753	188	81	membrane	membrane	NOUN
admet-2753	188	82	surface	surface	NOUN
admet-2753	188	83	)	)	PUNCT
admet-2753	188	84	,	,	PUNCT
admet-2753	188	85	using	use	VERB
admet-2753	188	86	buvari	buvari	NOUN
admet-2753	188	87	-	-	PUNCT
admet-2753	188	88	barcza	barcza	NOUN
admet-2753	189	1	[	[	X
admet-2753	189	2	51	51	NUM
admet-2753	189	3	]	]	PUNCT
admet-2753	189	4	method	method	NOUN
admet-2753	189	5	figure	figure	NOUN
admet-2753	189	6	6	6	NUM
admet-2753	189	7	.	.	PUNCT
admet-2753	189	8	schematic	schematic	ADJ
admet-2753	189	9	drawing	drawing	NOUN
admet-2753	189	10	of	of	ADP
admet-2753	189	11	membrane	membrane	NOUN
admet-2753	189	12	transport	transport	NOUN
admet-2753	189	13	in	in	ADP
admet-2753	189	14	case	case	NOUN
admet-2753	189	15	of	of	ADP
admet-2753	189	16	a	a	DET
admet-2753	189	17	)	)	PUNCT
admet-2753	189	18	lipophilic	lipophilic	ADJ
admet-2753	189	19	membrane	membrane	NOUN
admet-2753	189	20	b	b	NOUN
admet-2753	189	21	)	)	PUNCT
admet-2753	189	22	size	size	NOUN
admet-2753	189	23	-	-	PUNCT
admet-2753	189	24	exclusion	exclusion	NOUN
admet-2753	189	25	membrane	membrane	NOUN
admet-2753	189	26	(	(	PUNCT
admet-2753	189	27	api	api	NOUN
admet-2753	189	28	is	be	AUX
admet-2753	189	29	represented	represent	VERB
admet-2753	189	30	with	with	ADP
admet-2753	189	31	pink	pink	ADJ
admet-2753	189	32	hexagons	hexagon	NOUN
admet-2753	189	33	,	,	PUNCT
admet-2753	189	34	while	while	SCONJ
admet-2753	189	35	the	the	DET
admet-2753	189	36	cyclodextrin	cyclodextrin	NOUN
admet-2753	189	37	is	be	AUX
admet-2753	189	38	with	with	ADP
admet-2753	189	39	grey	grey	ADJ
admet-2753	189	40	cones	cone	NOUN
admet-2753	189	41	)	)	PUNCT
admet-2753	189	42	.	.	PUNCT
admet-2753	190	1	c0	c0	PROPN
admet-2753	190	2	m	m	PROPN
admet-2753	190	3	and	and	CCONJ
admet-2753	190	4	chm	chm	NOUN
admet-2753	190	5	m	m	VERB
admet-2753	190	6	are	be	AUX
admet-2753	190	7	the	the	DET
admet-2753	190	8	concentrations	concentration	NOUN
admet-2753	190	9	of	of	ADP
admet-2753	190	10	the	the	DET
admet-2753	190	11	uncharged	uncharged	ADJ
admet-2753	190	12	form	form	NOUN
admet-2753	190	13	of	of	ADP
admet-2753	190	14	the	the	DET
admet-2753	190	15	solute	solute	NOUN
admet-2753	190	16	within	within	ADP
admet-2753	190	17	the	the	DET
admet-2753	190	18	membrane	membrane	NOUN
admet-2753	190	19	at	at	ADP
admet-2753	190	20	the	the	DET
admet-2753	190	21	two	two	NUM
admet-2753	190	22	water	water	NOUN
admet-2753	190	23	–	–	PUNCT
admet-2753	190	24	membrane	membrane	NOUN
admet-2753	190	25	boundaries	boundary	NOUN
admet-2753	190	26	,	,	PUNCT
admet-2753	190	27	x	x	X
admet-2753	190	28	is	be	AUX
admet-2753	190	29	the	the	DET
admet-2753	190	30	width	width	NOUN
admet-2753	190	31	of	of	ADP
admet-2753	190	32	the	the	DET
admet-2753	190	33	membrane	membrane	NOUN
admet-2753	190	34	in	in	ADP
admet-2753	190	35	vitro	vitro	X
admet-2753	190	36	side	side	NOUN
admet-2753	190	37	-	-	PUNCT
admet-2753	190	38	by	by	ADP
admet-2753	190	39	-	-	PUNCT
admet-2753	190	40	side	side	NOUN
admet-2753	190	41	diffusion	diffusion	NOUN
admet-2753	190	42	cell	cell	NOUN
admet-2753	190	43	assays	assay	NOUN
admet-2753	190	44	during	during	ADP
admet-2753	190	45	the	the	DET
admet-2753	190	46	in	in	ADV
admet-2753	190	47	vitro	vitro	X
admet-2753	190	48	side	side	NOUN
admet-2753	190	49	-	-	PUNCT
admet-2753	190	50	by	by	ADP
admet-2753	190	51	-	-	PUNCT
admet-2753	190	52	side	side	NOUN
admet-2753	190	53	dissolution	dissolution	NOUN
admet-2753	190	54	cell	cell	NOUN
admet-2753	190	55	assays	assay	NOUN
admet-2753	190	56	,	,	PUNCT
admet-2753	190	57	the	the	DET
admet-2753	190	58	aim	aim	NOUN
admet-2753	190	59	was	be	AUX
admet-2753	190	60	to	to	PART
admet-2753	190	61	create	create	VERB
admet-2753	190	62	uwl	uwl	ADV
admet-2753	190	63	-	-	PUNCT
admet-2753	190	64	limited	limit	VERB
admet-2753	190	65	transport	transport	NOUN
admet-2753	190	66	for	for	ADP
admet-2753	190	67	the	the	DET
admet-2753	190	68	model	model	NOUN
admet-2753	190	69	api	api	NOUN
admet-2753	190	70	in	in	ADP
admet-2753	190	71	the	the	DET
admet-2753	190	72	absence	absence	NOUN
admet-2753	190	73	of	of	ADP
admet-2753	190	74	hp	hp	PROPN
admet-2753	190	75	-	-	PUNCT
admet-2753	190	76	β	β	NOUN
admet-2753	190	77	-	-	NOUN
admet-2753	190	78	cd	cd	NOUN
admet-2753	190	79	.	.	PUNCT
admet-2753	191	1	therefore	therefore	ADV
admet-2753	191	2	,	,	PUNCT
admet-2753	191	3	ph	ph	ADJ
admet-2753	191	4	10	10	NUM
admet-2753	191	5	media	medium	NOUN
admet-2753	191	6	was	be	AUX
admet-2753	191	7	used	use	VERB
admet-2753	191	8	in	in	ADP
admet-2753	191	9	both	both	DET
admet-2753	191	10	compartments	compartment	NOUN
admet-2753	191	11	,	,	PUNCT
admet-2753	191	12	and	and	CCONJ
admet-2753	191	13	the	the	DET
admet-2753	191	14	effect	effect	NOUN
admet-2753	191	15	of	of	ADP
admet-2753	191	16	the	the	DET
admet-2753	191	17	solubilizing	solubilize	VERB
admet-2753	191	18	agent	agent	NOUN
admet-2753	191	19	on	on	ADP
admet-2753	191	20	flux	flux	NOUN
admet-2753	191	21	was	be	AUX
admet-2753	191	22	studied	study	VERB
admet-2753	191	23	with	with	ADP
admet-2753	191	24	250	250	NUM
admet-2753	191	25	rpm	rpm	NOUN
admet-2753	191	26	stirring	stirring	NOUN
admet-2753	191	27	and	and	CCONJ
admet-2753	191	28	without	without	ADP
admet-2753	191	29	stirring	stir	VERB
admet-2753	191	30	.	.	PUNCT
admet-2753	192	1	three	three	NUM
admet-2753	192	2	different	different	ADJ
admet-2753	192	3	membrane	membrane	NOUN
admet-2753	192	4	types	type	NOUN
admet-2753	192	5	(	(	PUNCT
admet-2753	192	6	pvdf	pvdf	NOUN
admet-2753	192	7	filter	filter	NOUN
admet-2753	192	8	impregnated	impregnate	VERB
admet-2753	192	9	with	with	ADP
admet-2753	192	10	n	n	CCONJ
admet-2753	192	11	-	-	PUNCT
admet-2753	192	12	dodecane	dodecane	NOUN
admet-2753	192	13	)	)	PUNCT
admet-2753	192	14	and	and	CCONJ
admet-2753	192	15	two	two	NUM
admet-2753	192	16	size	size	NOUN
admet-2753	192	17	-	-	PUNCT
admet-2753	192	18	exclusion	exclusion	NOUN
admet-2753	192	19	membranes	membrane	NOUN
admet-2753	192	20	(	(	PUNCT
admet-2753	192	21	mwco	mwco	NOUN
admet-2753	192	22	=	=	SYM
admet-2753	192	23	1	1	NUM
admet-2753	192	24	and	and	CCONJ
admet-2753	192	25	6	6	NUM
admet-2753	192	26	kda	kda	NOUN
admet-2753	192	27	)	)	PUNCT
admet-2753	192	28	were	be	AUX
admet-2753	192	29	used	use	VERB
admet-2753	192	30	in	in	ADP
admet-2753	192	31	the	the	DET
admet-2753	192	32	study	study	NOUN
admet-2753	192	33	.	.	PUNCT
admet-2753	193	1	the	the	DET
admet-2753	193	2	lipophilic	lipophilic	ADJ
admet-2753	193	3	membrane	membrane	NOUN
admet-2753	193	4	was	be	AUX
admet-2753	193	5	a	a	DET
admet-2753	193	6	model	model	NOUN
admet-2753	193	7	for	for	ADP
admet-2753	193	8	the	the	DET
admet-2753	193	9	scenario	scenario	NOUN
admet-2753	193	10	where	where	SCONJ
admet-2753	193	11	the	the	DET
admet-2753	193	12	drug	drug	NOUN
admet-2753	193	13	is	be	AUX
admet-2753	193	14	able	able	ADJ
admet-2753	193	15	to	to	PART
admet-2753	193	16	permeate	permeate	VERB
admet-2753	193	17	the	the	DET
admet-2753	193	18	membrane	membrane	NOUN
admet-2753	193	19	,	,	PUNCT
admet-2753	193	20	but	but	CCONJ
admet-2753	193	21	the	the	DET
admet-2753	193	22	solubilizing	solubilize	VERB
admet-2753	193	23	agent	agent	NOUN
admet-2753	193	24	and	and	CCONJ
admet-2753	193	25	the	the	DET
admet-2753	193	26	drug	drug	NOUN
admet-2753	193	27	-	-	PUNCT
admet-2753	193	28	cyclodextrin	cyclodextrin	NOUN
admet-2753	193	29	complex	complex	NOUN
admet-2753	193	30	are	be	AUX
admet-2753	193	31	not	not	PART
admet-2753	193	32	.	.	PUNCT
admet-2753	194	1	while	while	SCONJ
admet-2753	194	2	in	in	ADP
admet-2753	194	3	the	the	DET
admet-2753	194	4	case	case	NOUN
admet-2753	194	5	of	of	ADP
admet-2753	194	6	the	the	DET
admet-2753	194	7	size	size	NOUN
admet-2753	194	8	-	-	PUNCT
admet-2753	194	9	exclusion	exclusion	NOUN
admet-2753	194	10	membrane	membrane	NOUN
admet-2753	194	11	,	,	PUNCT
admet-2753	194	12	both	both	CCONJ
admet-2753	194	13	the	the	DET
admet-2753	194	14	drug	drug	NOUN
admet-2753	194	15	and	and	CCONJ
admet-2753	194	16	the	the	DET
admet-2753	194	17	hp	hp	PROPN
admet-2753	194	18	-	-	PUNCT
admet-2753	194	19	β	β	NOUN
admet-2753	194	20	-	-	NOUN
admet-2753	194	21	cd	cd	NOUN
admet-2753	194	22	and	and	CCONJ
admet-2753	194	23	their	their	PRON
admet-2753	194	24	complex	complex	NOUN
admet-2753	194	25	are	be	AUX
admet-2753	194	26	able	able	ADJ
admet-2753	194	27	to	to	PART
admet-2753	194	28	go	go	VERB
admet-2753	194	29	through	through	ADP
admet-2753	194	30	(	(	PUNCT
admet-2753	194	31	see	see	VERB
admet-2753	194	32	the	the	DET
admet-2753	194	33	section	section	NOUN
admet-2753	194	34	on	on	ADP
admet-2753	194	35	membrane	membrane	NOUN
admet-2753	194	36	transport	transport	NOUN
admet-2753	194	37	of	of	ADP
admet-2753	194	38	hp	hp	PROPN
admet-2753	194	39	-	-	PUNCT
admet-2753	194	40	β	β	NOUN
admet-2753	194	41	-	-	NOUN
admet-2753	194	42	cd	cd	NOUN
admet-2753	194	43	)	)	PUNCT
admet-2753	194	44	.	.	PUNCT
admet-2753	195	1	during	during	ADP
admet-2753	195	2	the	the	DET
admet-2753	195	3	side	side	NOUN
admet-2753	195	4	-	-	PUNCT
admet-2753	195	5	by	by	ADP
admet-2753	195	6	-	-	PUNCT
admet-2753	195	7	side	side	NOUN
admet-2753	195	8	diffusion	diffusion	NOUN
admet-2753	195	9	cell	cell	NOUN
admet-2753	195	10	assays	assay	NOUN
admet-2753	195	11	,	,	PUNCT
admet-2753	195	12	in	in	ADP
admet-2753	195	13	most	most	ADJ
admet-2753	195	14	cases	case	NOUN
admet-2753	195	15	,	,	PUNCT
admet-2753	195	16	supersaturated	supersaturated	ADJ
admet-2753	195	17	solutions	solution	NOUN
admet-2753	195	18	were	be	AUX
admet-2753	195	19	created	create	VERB
admet-2753	195	20	in	in	ADP
admet-2753	195	21	the	the	DET
admet-2753	195	22	donor	donor	NOUN
admet-2753	195	23	compartment	compartment	NOUN
admet-2753	195	24	both	both	CCONJ
admet-2753	195	25	with	with	ADP
admet-2753	195	26	and	and	CCONJ
admet-2753	195	27	without	without	ADP
admet-2753	195	28	cd	cd	PROPN
admet-2753	195	29	present	present	NOUN
admet-2753	195	30	(	(	PUNCT
admet-2753	195	31	the	the	DET
admet-2753	195	32	donor	donor	NOUN
admet-2753	195	33	compartment	compartment	NOUN
admet-2753	195	34	is	be	AUX
admet-2753	195	35	considered	consider	VERB
admet-2753	195	36	supersaturated	supersaturated	ADJ
admet-2753	195	37	if	if	SCONJ
admet-2753	195	38	the	the	DET
admet-2753	195	39	concentration	concentration	NOUN
admet-2753	195	40	exceeds	exceed	VERB
admet-2753	195	41	the	the	DET
admet-2753	195	42	thermodynamic	thermodynamic	ADJ
admet-2753	195	43	solubility	solubility	NOUN
admet-2753	195	44	:	:	PUNCT
admet-2753	195	45	2.15	2.15	NUM
admet-2753	195	46	µg	µg	ADV
admet-2753	195	47	ml-1	ml-1	ADV
admet-2753	195	48	for	for	ADP
admet-2753	195	49	the	the	DET
admet-2753	195	50	plain	plain	ADJ
admet-2753	195	51	buffer	buffer	NOUN
admet-2753	195	52	and	and	CCONJ
admet-2753	195	53	6.69	6.69	NUM
admet-2753	195	54	µg	µg	NOUN
admet-2753	195	55	ml-1	ml-1	ADV
admet-2753	195	56	for	for	ADP
admet-2753	195	57	the	the	DET
admet-2753	195	58	hp	hp	PROPN
admet-2753	195	59	-	-	PUNCT
admet-2753	195	60	β	β	NOUN
admet-2753	195	61	-	-	ADJ
admet-2753	195	62	cd	cd	ADJ
admet-2753	195	63	containing	contain	VERB
admet-2753	195	64	buffer	buffer	NOUN
admet-2753	195	65	)	)	PUNCT
admet-2753	195	66	.	.	PUNCT
admet-2753	196	1	precipitation	precipitation	NOUN
admet-2753	196	2	was	be	AUX
admet-2753	196	3	monitored	monitor	VERB
admet-2753	196	4	in	in	ADP
admet-2753	196	5	real	real	ADJ
admet-2753	196	6	-	-	PUNCT
admet-2753	196	7	time	time	NOUN
admet-2753	196	8	(	(	PUNCT
admet-2753	196	9	see	see	VERB
admet-2753	196	10	supporting	support	VERB
admet-2753	196	11	information	information	NOUN
admet-2753	196	12	,	,	PUNCT
admet-2753	196	13	figure	figure	NOUN
admet-2753	196	14	s3	s3	PROPN
admet-2753	196	15	)	)	PUNCT
admet-2753	196	16	.	.	PUNCT
admet-2753	197	1	during	during	ADP
admet-2753	197	2	flux	flux	NOUN
admet-2753	197	3	calculation	calculation	NOUN
admet-2753	197	4	,	,	PUNCT
admet-2753	197	5	a	a	DET
admet-2753	197	6	time	time	NOUN
admet-2753	197	7	interval	interval	NOUN
admet-2753	197	8	was	be	AUX
admet-2753	197	9	chosen	choose	VERB
admet-2753	197	10	where	where	SCONJ
admet-2753	197	11	the	the	DET
admet-2753	197	12	donor	donor	NOUN
admet-2753	197	13	side	side	NOUN
admet-2753	197	14	was	be	AUX
admet-2753	197	15	stable	stable	ADJ
admet-2753	197	16	,	,	PUNCT
admet-2753	197	17	and	and	CCONJ
admet-2753	197	18	no	no	DET
admet-2753	197	19	precipitation	precipitation	NOUN
admet-2753	197	20	was	be	AUX
admet-2753	197	21	observed	observe	VERB
admet-2753	197	22	.	.	PUNCT
admet-2753	198	1	the	the	DET
admet-2753	198	2	flux	flux	NOUN
admet-2753	198	3	values	value	NOUN
admet-2753	198	4	obtained	obtain	VERB
admet-2753	198	5	from	from	ADP
admet-2753	198	6	in	in	ADP
admet-2753	198	7	vitro	vitro	X
admet-2753	198	8	side	side	NOUN
admet-2753	198	9	-	-	PUNCT
admet-2753	198	10	by	by	ADP
admet-2753	198	11	-	-	PUNCT
admet-2753	198	12	side	side	NOUN
admet-2753	198	13	diffusion	diffusion	NOUN
admet-2753	198	14	cell	cell	NOUN
admet-2753	198	15	assays	assay	NOUN
admet-2753	198	16	were	be	AUX
admet-2753	198	17	plotted	plot	VERB
admet-2753	198	18	as	as	ADP
admet-2753	198	19	a	a	DET
admet-2753	198	20	function	function	NOUN
admet-2753	198	21	of	of	ADP
admet-2753	198	22	car	car	NOUN
admet-2753	198	23	concentration	concentration	NOUN
admet-2753	198	24	in	in	ADP
admet-2753	198	25	the	the	DET
admet-2753	198	26	donor	donor	NOUN
admet-2753	198	27	compartment	compartment	NOUN
admet-2753	198	28	(	(	PUNCT
admet-2753	198	29	figure	figure	NOUN
admet-2753	198	30	7	7	NUM
admet-2753	198	31	)	)	PUNCT
admet-2753	198	32	.	.	PUNCT
admet-2753	199	1	the	the	DET
admet-2753	199	2	diagrams	diagram	NOUN
admet-2753	199	3	clearly	clearly	ADV
admet-2753	199	4	show	show	VERB
admet-2753	199	5	that	that	SCONJ
admet-2753	199	6	the	the	DET
admet-2753	199	7	highest	high	ADJ
admet-2753	199	8	fluxes	flux	NOUN
admet-2753	199	9	in	in	ADP
admet-2753	199	10	absolute	absolute	ADJ
admet-2753	199	11	value	value	NOUN
admet-2753	199	12	can	can	AUX
admet-2753	199	13	be	be	AUX
admet-2753	199	14	achieved	achieve	VERB
admet-2753	199	15	by	by	ADP
admet-2753	199	16	using	use	VERB
admet-2753	199	17	a	a	DET
admet-2753	199	18	lipophilic	lipophilic	ADJ
admet-2753	199	19	membrane	membrane	NOUN
admet-2753	199	20	,	,	PUNCT
admet-2753	199	21	250	250	NUM
admet-2753	199	22	rpm	rpm	NOUN
admet-2753	199	23	c	c	PROPN
admet-2753	199	24	h	h	NOUN
admet-2753	199	25	p	p	NOUN
admet-2753	199	26	-β	-β	PUNCT
admet-2753	199	27	-c	-c	PROPN
admet-2753	199	28	d	d	NOUN
admet-2753	199	29	/	/	SYM
admet-2753	199	30			NOUN
admet-2753	199	31	g	g	NOUN
admet-2753	199	32	m	m	NOUN
admet-2753	199	33	l	l	NOUN
admet-2753	199	34	-1	-1	X
admet-2753	199	35	c0	c0	PROPN
admet-2753	199	36	uwl	uwl	X
admet-2753	199	37	0	0	NUM
admet-2753	199	38	m	m	VERB
admet-2753	199	39	m	m	VERB
admet-2753	199	40	hmc	hmc	NOUN
admet-2753	199	41	x	x	X
admet-2753	199	42	c	c	X
admet-2753	199	43	⎯⎯⎯⎯⎯→	⎯⎯⎯⎯⎯→	X
admet-2753	199	44	ch	ch	PROPN
admet-2753	200	1	uwl	uwl	PROPN
admet-2753	200	2	c0	c0	PROPN
admet-2753	200	3	uwl	uwl	X
admet-2753	200	4	0	0	NUM
admet-2753	200	5	m	m	VERB
admet-2753	200	6	m	m	VERB
admet-2753	200	7	hmc	hmc	NOUN
admet-2753	200	8	x	x	X
admet-2753	200	9	c	c	X
admet-2753	200	10	⎯⎯⎯⎯⎯→	⎯⎯⎯⎯⎯→	X
admet-2753	200	11	ch	ch	PROPN
admet-2753	200	12	uwl	uwl	PROPN
admet-2753	200	13	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	VERB
admet-2753	200	14	p.	p.	NOUN
admet-2753	200	15	tőzsér	tőzsér	PROPN
admet-2753	200	16	et	et	PROPN
admet-2753	200	17	al	al	PROPN
admet-2753	200	18	.	.	PROPN
admet-2753	200	19	admet	admet	PROPN
admet-2753	200	20	&	&	CCONJ
admet-2753	200	21	dmpk	dmpk	PROPN
admet-2753	200	22	13(4	13(4	NUM
admet-2753	200	23	)	)	PUNCT
admet-2753	200	24	(	(	PUNCT
admet-2753	200	25	2025	2025	NUM
admet-2753	200	26	)	)	PUNCT
admet-2753	200	27	2753	2753	NUM
admet-2753	200	28	12	12	NUM
admet-2753	200	29	stirring	stirring	NOUN
admet-2753	200	30	,	,	PUNCT
admet-2753	200	31	and	and	CCONJ
admet-2753	200	32	no	no	DET
admet-2753	200	33	solubilizing	solubilize	VERB
admet-2753	200	34	agent	agent	NOUN
admet-2753	200	35	.	.	PUNCT
admet-2753	201	1	changing	change	VERB
admet-2753	201	2	the	the	DET
admet-2753	201	3	membrane	membrane	NOUN
admet-2753	201	4	to	to	ADP
admet-2753	201	5	a	a	DET
admet-2753	201	6	size	size	NOUN
admet-2753	201	7	-	-	PUNCT
admet-2753	201	8	exclusion	exclusion	NOUN
admet-2753	201	9	membrane	membrane	NOUN
admet-2753	201	10	or	or	CCONJ
admet-2753	201	11	leaving	leave	VERB
admet-2753	201	12	the	the	DET
admet-2753	201	13	setup	setup	NOUN
admet-2753	201	14	without	without	ADP
admet-2753	201	15	stirring	stirring	NOUN
admet-2753	201	16	causes	cause	NOUN
admet-2753	201	17	the	the	DET
admet-2753	201	18	flux	flux	NOUN
admet-2753	201	19	values	value	NOUN
admet-2753	201	20	to	to	PART
admet-2753	201	21	decrease	decrease	VERB
admet-2753	201	22	significantly	significantly	ADV
admet-2753	201	23	.	.	PUNCT
admet-2753	202	1	donor	donor	NOUN
admet-2753	202	2	concentration	concentration	NOUN
admet-2753	202	3	,	,	PUNCT
admet-2753	202	4	g	g	VERB
admet-2753	202	5	ml-1	ml-1	PRON
admet-2753	202	6	donor	donor	NOUN
admet-2753	202	7	concentration	concentration	NOUN
admet-2753	202	8	,	,	PUNCT
admet-2753	202	9	g	g	VERB
admet-2753	202	10	ml-1	ml-1	PRON
admet-2753	202	11	donor	donor	NOUN
admet-2753	202	12	concentration	concentration	NOUN
admet-2753	202	13	,	,	PUNCT
admet-2753	202	14	g	g	VERB
admet-2753	202	15	ml-1	ml-1	PRON
admet-2753	202	16	donor	donor	NOUN
admet-2753	202	17	concentration	concentration	NOUN
admet-2753	202	18	,	,	PUNCT
admet-2753	202	19	g	g	VERB
admet-2753	202	20	ml-1	ml-1	PRON
admet-2753	202	21	donor	donor	NOUN
admet-2753	202	22	concentration	concentration	NOUN
admet-2753	202	23	,	,	PUNCT
admet-2753	202	24	g	g	VERB
admet-2753	202	25	ml-1	ml-1	PRON
admet-2753	202	26	donor	donor	NOUN
admet-2753	202	27	concentration	concentration	NOUN
admet-2753	202	28	,	,	PUNCT
admet-2753	202	29	g	g	PROPN
admet-2753	202	30	ml-1	ml-1	PUNCT
admet-2753	202	31	figure	figure	VERB
admet-2753	202	32	7	7	NUM
admet-2753	202	33	flux	flux	NOUN
admet-2753	202	34	vs.	vs.	ADP
admet-2753	202	35	donor	donor	NOUN
admet-2753	202	36	concentration	concentration	NOUN
admet-2753	202	37	curves	curve	NOUN
admet-2753	202	38	in	in	ADP
admet-2753	202	39	ph	ph	ADJ
admet-2753	202	40	10	10	NUM
admet-2753	202	41	buffer	buffer	NOUN
admet-2753	202	42	with	with	ADP
admet-2753	202	43	250	250	NUM
admet-2753	202	44	rpm	rpm	ADJ
admet-2753	202	45	stirring	stirring	NOUN
admet-2753	202	46	rate	rate	NOUN
admet-2753	202	47	and	and	CCONJ
admet-2753	202	48	with	with	ADP
admet-2753	202	49	0	0	NUM
admet-2753	202	50	rpm	rpm	ADJ
admet-2753	202	51	stirring	stirring	NOUN
admet-2753	202	52	rate	rate	NOUN
admet-2753	202	53	,	,	PUNCT
admet-2753	202	54	in	in	ADP
admet-2753	202	55	case	case	NOUN
admet-2753	202	56	of	of	ADP
admet-2753	202	57	lipophilic	lipophilic	ADJ
admet-2753	202	58	membrane	membrane	NOUN
admet-2753	202	59	,	,	PUNCT
admet-2753	202	60	6	6	NUM
admet-2753	202	61	kda	kda	NOUN
admet-2753	202	62	and	and	CCONJ
admet-2753	202	63	1	1	NUM
admet-2753	202	64	kda	kda	NOUN
admet-2753	202	65	size	size	NOUN
admet-2753	202	66	-	-	PUNCT
admet-2753	202	67	exclusion	exclusion	NOUN
admet-2753	202	68	membranes	membrane	NOUN
admet-2753	202	69	.	.	PUNCT
admet-2753	203	1	no	no	DET
admet-2753	203	2	hp	hp	PROPN
admet-2753	203	3	-	-	PUNCT
admet-2753	203	4	β	β	NOUN
admet-2753	203	5	-	-	NOUN
admet-2753	203	6	cd	cd	NOUN
admet-2753	203	7	present	present	NOUN
admet-2753	203	8	on	on	ADP
admet-2753	203	9	either	either	DET
admet-2753	203	10	side	side	NOUN
admet-2753	203	11	of	of	ADP
admet-2753	203	12	the	the	DET
admet-2753	203	13	membrane	membrane	NOUN
admet-2753	203	14	with	with	ADP
admet-2753	203	15	red	red	ADJ
admet-2753	203	16	dots	dot	NOUN
admet-2753	203	17	,	,	PUNCT
admet-2753	203	18	addition	addition	NOUN
admet-2753	203	19	of	of	ADP
admet-2753	203	20	hp	hp	NOUN
admet-2753	203	21	-	-	PUNCT
admet-2753	203	22	β	β	NOUN
admet-2753	203	23	-	-	NOUN
admet-2753	203	24	cd	cd	NOUN
admet-2753	203	25	to	to	PART
admet-2753	203	26	donor	donor	VERB
admet-2753	203	27	side	side	NOUN
admet-2753	203	28	with	with	ADP
admet-2753	203	29	green	green	ADJ
admet-2753	203	30	dots	dot	NOUN
admet-2753	203	31	the	the	DET
admet-2753	203	32	effect	effect	NOUN
admet-2753	203	33	of	of	ADP
admet-2753	203	34	solubilizing	solubilize	VERB
admet-2753	203	35	agent	agent	NOUN
admet-2753	203	36	was	be	AUX
admet-2753	203	37	evaluated	evaluate	VERB
admet-2753	203	38	by	by	ADP
admet-2753	203	39	comparing	compare	VERB
admet-2753	203	40	the	the	DET
admet-2753	203	41	line	line	NOUN
admet-2753	203	42	of	of	ADP
admet-2753	203	43	the	the	DET
admet-2753	203	44	plain	plain	ADJ
admet-2753	203	45	buffer	buffer	NOUN
admet-2753	203	46	(	(	PUNCT
admet-2753	203	47	red	red	ADJ
admet-2753	203	48	)	)	PUNCT
admet-2753	203	49	and	and	CCONJ
admet-2753	203	50	the	the	DET
admet-2753	203	51	buffer	buffer	NOUN
admet-2753	203	52	with	with	ADP
admet-2753	203	53	hp	hp	ADJ
admet-2753	203	54	-	-	PUNCT
admet-2753	203	55	β	β	NOUN
admet-2753	203	56	-	-	NOUN
admet-2753	203	57	cd	cd	ADJ
admet-2753	203	58	(	(	PUNCT
admet-2753	203	59	green	green	NOUN
admet-2753	203	60	)	)	PUNCT
admet-2753	203	61	with	with	ADP
admet-2753	203	62	a	a	DET
admet-2753	203	63	homogeneity	homogeneity	NOUN
admet-2753	203	64	of	of	ADP
admet-2753	203	65	slopes	slope	NOUN
admet-2753	203	66	test	test	NOUN
admet-2753	203	67	in	in	ADP
admet-2753	203	68	all	all	DET
admet-2753	203	69	6	6	NUM
admet-2753	203	70	cases	case	NOUN
admet-2753	203	71	depicted	depict	VERB
admet-2753	203	72	in	in	ADP
admet-2753	203	73	figure	figure	NOUN
admet-2753	203	74	7	7	NUM
admet-2753	203	75	.	.	PUNCT
admet-2753	204	1	the	the	DET
admet-2753	204	2	result	result	NOUN
admet-2753	204	3	of	of	ADP
admet-2753	204	4	the	the	DET
admet-2753	204	5	statistical	statistical	ADJ
admet-2753	204	6	analysis	analysis	NOUN
admet-2753	204	7	(	(	PUNCT
admet-2753	204	8	table	table	NOUN
admet-2753	204	9	5	5	NUM
admet-2753	204	10	)	)	PUNCT
admet-2753	204	11	shows	show	VERB
admet-2753	204	12	that	that	SCONJ
admet-2753	204	13	in	in	ADP
admet-2753	204	14	the	the	DET
admet-2753	204	15	case	case	NOUN
admet-2753	204	16	of	of	ADP
admet-2753	204	17	250	250	NUM
admet-2753	204	18	rpm	rpm	NOUN
admet-2753	204	19	stirring	stirring	NOUN
admet-2753	204	20	for	for	ADP
admet-2753	204	21	all	all	DET
admet-2753	204	22	3	3	NUM
admet-2753	204	23	membranes	membrane	NOUN
admet-2753	204	24	,	,	PUNCT
admet-2753	204	25	the	the	DET
admet-2753	204	26	solubilizing	solubilize	VERB
admet-2753	204	27	additive	additive	NOUN
admet-2753	204	28	causes	cause	VERB
admet-2753	204	29	the	the	DET
admet-2753	204	30	slope	slope	NOUN
admet-2753	204	31	of	of	ADP
admet-2753	204	32	the	the	DET
admet-2753	204	33	red	red	ADJ
admet-2753	204	34	and	and	CCONJ
admet-2753	204	35	green	green	ADJ
admet-2753	204	36	lines	line	NOUN
admet-2753	204	37	to	to	PART
admet-2753	204	38	differ	differ	VERB
admet-2753	204	39	significantly	significantly	ADV
admet-2753	204	40	.	.	PUNCT
admet-2753	205	1	the	the	DET
admet-2753	205	2	slope	slope	NOUN
admet-2753	205	3	is	be	AUX
admet-2753	205	4	directly	directly	ADV
admet-2753	205	5	proportional	proportional	ADJ
admet-2753	205	6	to	to	ADP
admet-2753	205	7	the	the	DET
admet-2753	205	8	permeability	permeability	NOUN
admet-2753	205	9	,	,	PUNCT
admet-2753	205	10	meaning	mean	VERB
admet-2753	205	11	that	that	SCONJ
admet-2753	205	12	in	in	ADP
admet-2753	205	13	the	the	DET
admet-2753	205	14	case	case	NOUN
admet-2753	205	15	of	of	ADP
admet-2753	205	16	the	the	DET
admet-2753	205	17	stirred	stirred	ADJ
admet-2753	205	18	configuration	configuration	NOUN
admet-2753	205	19	,	,	PUNCT
admet-2753	205	20	the	the	DET
admet-2753	205	21	addition	addition	NOUN
admet-2753	205	22	of	of	ADP
admet-2753	205	23	hp	hp	NOUN
admet-2753	205	24	-	-	PUNCT
admet-2753	205	25	β	β	NOUN
admet-2753	205	26	-	-	NOUN
admet-2753	205	27	cd	cd	NOUN
admet-2753	205	28	causes	cause	VERB
admet-2753	205	29	a	a	DET
admet-2753	205	30	significant	significant	ADJ
admet-2753	205	31	decrease	decrease	NOUN
admet-2753	205	32	in	in	ADP
admet-2753	205	33	the	the	DET
admet-2753	205	34	permeability	permeability	NOUN
admet-2753	205	35	values	value	NOUN
admet-2753	205	36	.	.	PUNCT
admet-2753	206	1	on	on	ADP
admet-2753	206	2	the	the	DET
admet-2753	206	3	other	other	ADJ
admet-2753	206	4	hand	hand	NOUN
admet-2753	206	5	,	,	PUNCT
admet-2753	206	6	in	in	ADP
admet-2753	206	7	the	the	DET
admet-2753	206	8	case	case	NOUN
admet-2753	206	9	of	of	ADP
admet-2753	206	10	the	the	DET
admet-2753	206	11	non	non	ADJ
admet-2753	206	12	-	-	ADJ
admet-2753	206	13	stirred	stirred	ADJ
admet-2753	206	14	set	set	NOUN
admet-2753	206	15	-	-	PUNCT
admet-2753	206	16	up	up	NOUN
admet-2753	206	17	for	for	ADP
admet-2753	206	18	the	the	DET
admet-2753	206	19	sizeexclusion	sizeexclusion	NOUN
admet-2753	206	20	membranes	membrane	NOUN
admet-2753	206	21	,	,	PUNCT
admet-2753	206	22	the	the	DET
admet-2753	206	23	addition	addition	NOUN
admet-2753	206	24	of	of	ADP
admet-2753	206	25	cd	cd	PROPN
admet-2753	206	26	only	only	ADV
admet-2753	206	27	causes	cause	VERB
admet-2753	206	28	a	a	DET
admet-2753	206	29	smaller	small	ADJ
admet-2753	206	30	effect	effect	NOUN
admet-2753	206	31	in	in	ADP
admet-2753	206	32	the	the	DET
admet-2753	206	33	slopes	slope	NOUN
admet-2753	206	34	,	,	PUNCT
admet-2753	206	35	therefore	therefore	ADV
admet-2753	206	36	,	,	PUNCT
admet-2753	206	37	in	in	ADP
admet-2753	206	38	the	the	DET
admet-2753	206	39	papp	papp	NOUN
admet-2753	206	40	values	value	NOUN
admet-2753	206	41	.	.	PUNCT
admet-2753	207	1	table	table	NOUN
admet-2753	207	2	5	5	NUM
admet-2753	207	3	.	.	PUNCT
admet-2753	207	4	homogeneity	homogeneity	NOUN
admet-2753	207	5	of	of	ADP
admet-2753	207	6	slopes	slope	NOUN
admet-2753	207	7	test	test	NOUN
admet-2753	207	8	results	result	NOUN
admet-2753	207	9	for	for	ADP
admet-2753	207	10	flux	flux	NOUN
admet-2753	207	11	-	-	PUNCT
admet-2753	207	12	donor	donor	NOUN
admet-2753	207	13	concentration	concentration	NOUN
admet-2753	207	14	curves	curve	NOUN
admet-2753	207	15	in	in	ADP
admet-2753	207	16	ph	ph	ADJ
admet-2753	207	17	10	10	NUM
admet-2753	207	18	buffer	buffer	NOUN
admet-2753	207	19	with	with	ADP
admet-2753	207	20	250	250	NUM
admet-2753	207	21	rpm	rpm	ADJ
admet-2753	207	22	stirring	stirring	NOUN
admet-2753	207	23	rate	rate	NOUN
admet-2753	207	24	and	and	CCONJ
admet-2753	207	25	with	with	ADP
admet-2753	207	26	0	0	NUM
admet-2753	207	27	rpm	rpm	ADJ
admet-2753	207	28	stirring	stirring	NOUN
admet-2753	207	29	rate	rate	NOUN
admet-2753	207	30	,	,	PUNCT
admet-2753	207	31	in	in	ADP
admet-2753	207	32	case	case	NOUN
admet-2753	207	33	of	of	ADP
admet-2753	207	34	lipophilic	lipophilic	ADJ
admet-2753	207	35	membrane	membrane	NOUN
admet-2753	207	36	,	,	PUNCT
admet-2753	207	37	6	6	NUM
admet-2753	207	38	kda	kda	NOUN
admet-2753	207	39	and	and	CCONJ
admet-2753	207	40	1	1	NUM
admet-2753	207	41	kda	kda	NOUN
admet-2753	207	42	size	size	NOUN
admet-2753	207	43	-	-	PUNCT
admet-2753	207	44	exclusion	exclusion	NOUN
admet-2753	207	45	membranes	membrane	NOUN
admet-2753	207	46	.	.	PUNCT
admet-2753	208	1	p	p	X
admet-2753	208	2	-	-	PUNCT
admet-2753	208	3	value	value	NOUN
admet-2753	208	4	for	for	ADP
admet-2753	208	5	250	250	NUM
admet-2753	208	6	rpm	rpm	NOUN
admet-2753	208	7	p	p	NOUN
admet-2753	208	8	-	-	PUNCT
admet-2753	208	9	value	value	NOUN
admet-2753	208	10	for	for	ADP
admet-2753	208	11	0	0	NUM
admet-2753	208	12	rpm	rpm	NOUN
admet-2753	208	13	lipophilic	lipophilic	NOUN
admet-2753	208	14	0.000000	0.000000	NUM
admet-2753	208	15	0.000481	0.000481	NUM
admet-2753	208	16	1	1	NUM
admet-2753	208	17	kda	kda	NOUN
admet-2753	208	18	0.000033	0.000033	NUM
admet-2753	208	19	0.012039	0.012039	NUM
admet-2753	208	20	6	6	NUM
admet-2753	208	21	kda	kda	NOUN
admet-2753	208	22	0.000000	0.000000	NUM
admet-2753	208	23	0.962032	0.962032	NUM
admet-2753	208	24	to	to	PART
admet-2753	208	25	evaluate	evaluate	VERB
admet-2753	208	26	the	the	DET
admet-2753	208	27	effect	effect	NOUN
admet-2753	208	28	of	of	ADP
admet-2753	208	29	all	all	DET
admet-2753	208	30	factors	factor	NOUN
admet-2753	208	31	(	(	PUNCT
admet-2753	208	32	membrane	membrane	NOUN
admet-2753	208	33	type	type	NOUN
admet-2753	208	34	,	,	PUNCT
admet-2753	208	35	stirring	stir	VERB
admet-2753	208	36	speed	speed	NOUN
admet-2753	208	37	,	,	PUNCT
admet-2753	208	38	and	and	CCONJ
admet-2753	208	39	the	the	DET
admet-2753	208	40	presence	presence	NOUN
admet-2753	208	41	of	of	ADP
admet-2753	208	42	solubilizing	solubilize	VERB
admet-2753	208	43	additive	additive	NOUN
admet-2753	208	44	)	)	PUNCT
admet-2753	208	45	,	,	PUNCT
admet-2753	208	46	first	first	ADV
admet-2753	208	47	,	,	PUNCT
admet-2753	208	48	the	the	DET
admet-2753	208	49	permeability	permeability	NOUN
admet-2753	208	50	values	value	NOUN
admet-2753	208	51	were	be	AUX
admet-2753	208	52	calculated	calculate	VERB
admet-2753	208	53	from	from	ADP
admet-2753	208	54	flux	flux	NOUN
admet-2753	208	55	and	and	CCONJ
admet-2753	208	56	donor	donor	NOUN
admet-2753	208	57	concentration	concentration	NOUN
admet-2753	208	58	data	datum	NOUN
admet-2753	208	59	(	(	PUNCT
admet-2753	208	60	see	see	VERB
admet-2753	208	61	equation	equation	NOUN
admet-2753	208	62	(	(	PUNCT
admet-2753	208	63	1	1	NUM
admet-2753	208	64	)	)	PUNCT
admet-2753	208	65	)	)	PUNCT
admet-2753	208	66	.	.	PUNCT
admet-2753	209	1	apparent	apparent	ADJ
admet-2753	209	2	permeability	permeability	NOUN
admet-2753	209	3	(	(	PUNCT
admet-2753	209	4	papp	papp	NOUN
admet-2753	209	5	)	)	PUNCT
admet-2753	209	6	,	,	PUNCT
admet-2753	209	7	data	datum	NOUN
admet-2753	209	8	are	be	AUX
admet-2753	209	9	presented	present	VERB
admet-2753	209	10	in	in	ADP
admet-2753	209	11	figure	figure	NOUN
admet-2753	209	12	8	8	NUM
admet-2753	209	13	.	.	PUNCT
admet-2753	210	1	statistical	statistical	ADJ
admet-2753	210	2	analysis	analysis	NOUN
admet-2753	210	3	(	(	PUNCT
admet-2753	210	4	3way	3way	NOUN
admet-2753	210	5	anova	anova	PROPN
admet-2753	210	6	factorial	factorial	NOUN
admet-2753	210	7	design	design	NOUN
admet-2753	210	8	)	)	PUNCT
admet-2753	210	9	showed	show	VERB
admet-2753	210	10	that	that	SCONJ
admet-2753	210	11	all	all	DET
admet-2753	210	12	three	three	NUM
admet-2753	210	13	factors	factor	NOUN
admet-2753	210	14	have	have	VERB
admet-2753	210	15	a	a	DET
admet-2753	210	16	significant	significant	ADJ
admet-2753	210	17	effect	effect	NOUN
admet-2753	210	18	on	on	ADP
admet-2753	210	19	the	the	DET
admet-2753	210	20	apparent	apparent	ADJ
admet-2753	210	21	permeability	permeability	NOUN
admet-2753	210	22	.	.	PUNCT
admet-2753	211	1	in	in	ADP
admet-2753	211	2	the	the	DET
admet-2753	211	3	case	case	NOUN
admet-2753	211	4	of	of	ADP
admet-2753	211	5	the	the	DET
admet-2753	211	6	different	different	ADJ
admet-2753	211	7	membrane	membrane	NOUN
admet-2753	211	8	types	type	NOUN
admet-2753	211	9	,	,	PUNCT
admet-2753	211	10	the	the	DET
admet-2753	211	11	lipophilic	lipophilic	ADJ
admet-2753	211	12	membrane	membrane	NOUN
admet-2753	211	13	showed	show	VERB
admet-2753	211	14	significantly	significantly	ADV
admet-2753	211	15	different	different	ADJ
admet-2753	211	16	papp	papp	NOUN
admet-2753	211	17	values	value	NOUN
admet-2753	211	18	(	(	PUNCT
admet-2753	211	19	p	p	X
admet-2753	211	20	<	<	X
admet-2753	211	21	0.00001	0.00001	NUM
admet-2753	211	22	)	)	PUNCT
admet-2753	211	23	,	,	PUNCT
admet-2753	211	24	whereas	whereas	SCONJ
admet-2753	211	25	no	no	DET
admet-2753	211	26	significant	significant	ADJ
admet-2753	211	27	difference	difference	NOUN
admet-2753	211	28	could	could	AUX
admet-2753	211	29	be	be	AUX
admet-2753	211	30	observed	observe	VERB
admet-2753	211	31	between	between	ADP
admet-2753	211	32	the	the	DET
admet-2753	211	33	two	two	NUM
admet-2753	211	34	size	size	NOUN
admet-2753	211	35	-	-	PUNCT
admet-2753	211	36	exclusion	exclusion	NOUN
admet-2753	211	37	membranes	membrane	NOUN
admet-2753	211	38	with	with	ADP
admet-2753	211	39	different	different	ADJ
admet-2753	211	40	mwcos	mwco	NOUN
admet-2753	211	41	.	.	PUNCT
admet-2753	212	1	the	the	DET
admet-2753	212	2	addition	addition	NOUN
admet-2753	212	3	of	of	ADP
admet-2753	212	4	hp	hp	NOUN
admet-2753	212	5	-	-	PUNCT
admet-2753	212	6	β	β	NOUN
admet-2753	212	7	-	-	NOUN
admet-2753	212	8	cd	cd	NOUN
admet-2753	212	9	significantly	significantly	ADV
admet-2753	212	10	decreased	decrease	VERB
admet-2753	212	11	the	the	DET
admet-2753	212	12	papp	papp	NOUN
admet-2753	212	13	value	value	NOUN
admet-2753	212	14	(	(	PUNCT
admet-2753	212	15	p<0.00001	p<0.00001	PROPN
admet-2753	212	16	)	)	PUNCT
admet-2753	212	17	,	,	PUNCT
admet-2753	213	1	f	f	PROPN
admet-2753	213	2	lu	lu	PROPN
admet-2753	213	3	x	x	NOUN
admet-2753	213	4	,	,	PUNCT
admet-2753	213	5			NOUN
admet-2753	213	6	g	g	NOUN
admet-2753	213	7	m	m	NOUN
admet-2753	213	8	in	in	ADP
admet-2753	213	9	-1	-1	PROPN
admet-2753	214	1	c	c	NOUN
admet-2753	214	2	m	m	VERB
admet-2753	214	3	--2	--2	INTJ
admet-2753	214	4	f	f	PROPN
admet-2753	214	5	lu	lu	PROPN
admet-2753	214	6	x	x	NOUN
admet-2753	214	7	,	,	PUNCT
admet-2753	214	8			NOUN
admet-2753	214	9	g	g	NOUN
admet-2753	214	10	m	m	NOUN
admet-2753	214	11	in	in	ADP
admet-2753	214	12	-1	-1	PROPN
admet-2753	215	1	c	c	NOUN
admet-2753	215	2	m	m	VERB
admet-2753	215	3	--2	--2	INTJ
admet-2753	215	4	f	f	PROPN
admet-2753	215	5	lu	lu	PROPN
admet-2753	215	6	x	x	NOUN
admet-2753	215	7	,	,	PUNCT
admet-2753	215	8			NOUN
admet-2753	215	9	g	g	NOUN
admet-2753	215	10	m	m	NOUN
admet-2753	215	11	in	in	ADP
admet-2753	215	12	-1	-1	PROPN
admet-2753	216	1	c	c	NOUN
admet-2753	216	2	m	m	VERB
admet-2753	216	3	--2	--2	INTJ
admet-2753	216	4	f	f	PROPN
admet-2753	216	5	lu	lu	PROPN
admet-2753	216	6	x	x	NOUN
admet-2753	216	7	,	,	PUNCT
admet-2753	216	8			NOUN
admet-2753	216	9	g	g	NOUN
admet-2753	216	10	m	m	NOUN
admet-2753	216	11	in	in	ADP
admet-2753	216	12	-1	-1	PROPN
admet-2753	217	1	c	c	NOUN
admet-2753	217	2	m	m	VERB
admet-2753	217	3	--2	--2	INTJ
admet-2753	217	4	f	f	PROPN
admet-2753	217	5	lu	lu	PROPN
admet-2753	217	6	x	x	NOUN
admet-2753	217	7	,	,	PUNCT
admet-2753	217	8			NOUN
admet-2753	217	9	g	g	NOUN
admet-2753	217	10	m	m	NOUN
admet-2753	217	11	in	in	ADP
admet-2753	217	12	-1	-1	PROPN
admet-2753	218	1	c	c	NOUN
admet-2753	218	2	m	m	VERB
admet-2753	218	3	--2	--2	INTJ
admet-2753	218	4	f	f	PROPN
admet-2753	218	5	lu	lu	PROPN
admet-2753	218	6	x	x	NOUN
admet-2753	218	7	,	,	PUNCT
admet-2753	218	8			NOUN
admet-2753	218	9	g	g	NOUN
admet-2753	218	10	m	m	NOUN
admet-2753	218	11	in	in	ADP
admet-2753	218	12	-1	-1	PROPN
admet-2753	219	1	c	c	PROPN
admet-2753	219	2	m	m	VERB
admet-2753	219	3	--2	--2	ADJ
admet-2753	219	4	admet	admet	PROPN
admet-2753	219	5	&	&	CCONJ
admet-2753	219	6	dmpk	dmpk	PROPN
admet-2753	219	7	13(4	13(4	NUM
admet-2753	219	8	)	)	PUNCT
admet-2753	219	9	(	(	PUNCT
admet-2753	219	10	2025	2025	NUM
admet-2753	219	11	)	)	PUNCT
admet-2753	219	12	2753	2753	NUM
admet-2753	219	13	comparison	comparison	NOUN
admet-2753	219	14	of	of	ADP
admet-2753	219	15	lipophilic	lipophilic	ADJ
admet-2753	219	16	and	and	CCONJ
admet-2753	219	17	size	size	NOUN
admet-2753	219	18	-	-	PUNCT
admet-2753	219	19	exclusion	exclusion	NOUN
admet-2753	219	20	membranes	membrane	NOUN
admet-2753	219	21	doi	doi	NOUN
admet-2753	219	22	:	:	PUNCT
admet-2753	219	23	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	219	24	13	13	NUM
admet-2753	219	25	demonstrating	demonstrate	VERB
admet-2753	219	26	the	the	DET
admet-2753	219	27	solubility	solubility	NOUN
admet-2753	219	28	-	-	PUNCT
admet-2753	219	29	permeability	permeability	NOUN
admet-2753	219	30	interplay	interplay	NOUN
admet-2753	219	31	[	[	X
admet-2753	219	32	26,27,58,59	26,27,58,59	NUM
admet-2753	219	33	]	]	PUNCT
admet-2753	219	34	.	.	PUNCT
admet-2753	220	1	by	by	ADP
admet-2753	220	2	introducing	introduce	VERB
admet-2753	220	3	sufficient	sufficient	ADJ
admet-2753	220	4	stirring	stirring	NOUN
admet-2753	220	5	(	(	PUNCT
admet-2753	220	6	250	250	NUM
admet-2753	220	7	rpm	rpm	NOUN
admet-2753	220	8	)	)	PUNCT
admet-2753	220	9	the	the	DET
admet-2753	220	10	papp	papp	NOUN
admet-2753	220	11	values	value	NOUN
admet-2753	220	12	significantly	significantly	ADV
admet-2753	220	13	increased	increase	VERB
admet-2753	220	14	in	in	ADP
admet-2753	220	15	all	all	DET
admet-2753	220	16	cases	case	NOUN
admet-2753	220	17	(	(	PUNCT
admet-2753	220	18	p	p	X
admet-2753	220	19	<	<	X
admet-2753	220	20	0.00001	0.00001	NUM
admet-2753	220	21	)	)	PUNCT
admet-2753	220	22	,	,	PUNCT
admet-2753	220	23	which	which	DET
admet-2753	220	24	results	result	NOUN
admet-2753	220	25	agree	agree	VERB
admet-2753	220	26	with	with	ADP
admet-2753	220	27	literature	literature	NOUN
admet-2753	220	28	data	data	PROPN
admet-2753	220	29	.	.	PUNCT
admet-2753	221	1	figure	figure	NOUN
admet-2753	221	2	8	8	NUM
admet-2753	221	3	.	.	PUNCT
admet-2753	222	1	apparent	apparent	ADJ
admet-2753	222	2	permeability	permeability	NOUN
admet-2753	222	3	values	value	NOUN
admet-2753	222	4	in	in	ADP
admet-2753	222	5	ph	ph	ADJ
admet-2753	222	6	10	10	NUM
admet-2753	222	7	buffer	buffer	NOUN
admet-2753	222	8	with	with	ADP
admet-2753	222	9	250	250	NUM
admet-2753	222	10	rpm	rpm	ADJ
admet-2753	222	11	stirring	stirring	NOUN
admet-2753	222	12	rate	rate	NOUN
admet-2753	222	13	and	and	CCONJ
admet-2753	222	14	with	with	ADP
admet-2753	222	15	0	0	NUM
admet-2753	222	16	rpm	rpm	ADJ
admet-2753	222	17	stirring	stirring	NOUN
admet-2753	222	18	rate	rate	NOUN
admet-2753	222	19	,	,	PUNCT
admet-2753	222	20	in	in	ADP
admet-2753	222	21	case	case	NOUN
admet-2753	222	22	of	of	ADP
admet-2753	222	23	lipophilic	lipophilic	ADJ
admet-2753	222	24	membrane	membrane	NOUN
admet-2753	222	25	,	,	PUNCT
admet-2753	222	26	6	6	NUM
admet-2753	222	27	kda	kda	NOUN
admet-2753	222	28	and	and	CCONJ
admet-2753	222	29	1	1	NUM
admet-2753	222	30	kda	kda	NOUN
admet-2753	222	31	size	size	NOUN
admet-2753	222	32	-	-	PUNCT
admet-2753	222	33	exclusion	exclusion	NOUN
admet-2753	222	34	membranes	membrane	NOUN
admet-2753	222	35	.	.	PUNCT
admet-2753	223	1	no	no	DET
admet-2753	223	2	hp	hp	PROPN
admet-2753	223	3	-	-	PUNCT
admet-2753	223	4	β	β	NOUN
admet-2753	223	5	-	-	NOUN
admet-2753	223	6	cd	cd	NOUN
admet-2753	223	7	present	present	NOUN
admet-2753	223	8	on	on	ADP
admet-2753	223	9	either	either	DET
admet-2753	223	10	side	side	NOUN
admet-2753	223	11	of	of	ADP
admet-2753	223	12	the	the	DET
admet-2753	223	13	membrane	membrane	NOUN
admet-2753	223	14	,	,	PUNCT
admet-2753	223	15	with	with	ADP
admet-2753	223	16	red	red	ADJ
admet-2753	223	17	,	,	PUNCT
admet-2753	223	18	addition	addition	NOUN
admet-2753	223	19	of	of	ADP
admet-2753	223	20	hp	hp	NOUN
admet-2753	223	21	-	-	PUNCT
admet-2753	223	22	β	β	NOUN
admet-2753	223	23	-	-	NOUN
admet-2753	223	24	cd	cd	NOUN
admet-2753	223	25	to	to	ADP
admet-2753	223	26	the	the	DET
admet-2753	223	27	donor	donor	NOUN
admet-2753	223	28	side	side	NOUN
admet-2753	223	29	with	with	ADP
admet-2753	223	30	green	green	PROPN
admet-2753	223	31	moreover	moreover	ADV
admet-2753	223	32	,	,	PUNCT
admet-2753	223	33	the	the	PRON
admet-2753	223	34	between	between	ADP
admet-2753	223	35	effects	effect	NOUN
admet-2753	223	36	were	be	AUX
admet-2753	223	37	also	also	ADV
admet-2753	223	38	evaluated	evaluate	VERB
admet-2753	223	39	as	as	ADP
admet-2753	223	40	part	part	NOUN
admet-2753	223	41	of	of	ADP
admet-2753	223	42	the	the	DET
admet-2753	223	43	statistical	statistical	ADJ
admet-2753	223	44	analysis	analysis	NOUN
admet-2753	223	45	.	.	PUNCT
admet-2753	224	1	all	all	DET
admet-2753	224	2	three	three	NUM
admet-2753	224	3	betweeneffects	betweeneffect	NOUN
admet-2753	224	4	were	be	AUX
admet-2753	224	5	found	find	VERB
admet-2753	224	6	to	to	PART
admet-2753	224	7	significantly	significantly	ADV
admet-2753	224	8	influence	influence	VERB
admet-2753	224	9	the	the	DET
admet-2753	224	10	papp	papp	NOUN
admet-2753	224	11	value	value	NOUN
admet-2753	224	12	(	(	PUNCT
admet-2753	224	13	see	see	VERB
admet-2753	224	14	table	table	NOUN
admet-2753	224	15	s2	s2	PROPN
admet-2753	224	16	)	)	PUNCT
admet-2753	224	17	.	.	PUNCT
admet-2753	225	1	interestingly	interestingly	ADV
admet-2753	225	2	,	,	PUNCT
admet-2753	225	3	the	the	DET
admet-2753	225	4	between	between	NOUN
admet-2753	225	5	-	-	PUNCT
admet-2753	225	6	effect	effect	NOUN
admet-2753	225	7	diagrams	diagram	NOUN
admet-2753	225	8	showed	show	VERB
admet-2753	225	9	that	that	SCONJ
admet-2753	225	10	in	in	ADP
admet-2753	225	11	the	the	DET
admet-2753	225	12	presence	presence	NOUN
admet-2753	225	13	of	of	ADP
admet-2753	225	14	hp	hp	PROPN
admet-2753	225	15	-	-	PUNCT
admet-2753	225	16	β	β	NOUN
admet-2753	225	17	-	-	NOUN
admet-2753	225	18	cd	cd	NOUN
admet-2753	225	19	in	in	ADP
admet-2753	225	20	the	the	DET
admet-2753	225	21	donor	donor	NOUN
admet-2753	225	22	compartment	compartment	NOUN
admet-2753	225	23	,	,	PUNCT
admet-2753	225	24	the	the	DET
admet-2753	225	25	introduction	introduction	NOUN
admet-2753	225	26	of	of	ADP
admet-2753	225	27	stirring	stirring	NOUN
admet-2753	225	28	causes	cause	NOUN
admet-2753	225	29	a	a	DET
admet-2753	225	30	significantly	significantly	ADV
admet-2753	225	31	smaller	small	ADJ
admet-2753	225	32	increase	increase	NOUN
admet-2753	225	33	in	in	ADP
admet-2753	225	34	the	the	DET
admet-2753	225	35	papp	papp	NOUN
admet-2753	225	36	value	value	NOUN
admet-2753	225	37	than	than	ADP
admet-2753	225	38	in	in	ADP
admet-2753	225	39	the	the	DET
admet-2753	225	40	case	case	NOUN
admet-2753	225	41	of	of	ADP
admet-2753	225	42	the	the	DET
admet-2753	225	43	plain	plain	ADJ
admet-2753	225	44	buffer	buffer	NOUN
admet-2753	225	45	.	.	PUNCT
admet-2753	226	1	these	these	DET
admet-2753	226	2	diagrams	diagram	NOUN
admet-2753	226	3	also	also	ADV
admet-2753	226	4	showed	show	VERB
admet-2753	226	5	that	that	SCONJ
admet-2753	226	6	in	in	ADP
admet-2753	226	7	the	the	DET
admet-2753	226	8	presence	presence	NOUN
admet-2753	226	9	of	of	ADP
admet-2753	226	10	cd	cd	PROPN
admet-2753	226	11	,	,	PUNCT
admet-2753	226	12	the	the	DET
admet-2753	226	13	differences	difference	NOUN
admet-2753	226	14	between	between	ADP
admet-2753	226	15	the	the	DET
admet-2753	226	16	lipophilic	lipophilic	ADJ
admet-2753	226	17	and	and	CCONJ
admet-2753	226	18	size	size	NOUN
admet-2753	226	19	-	-	PUNCT
admet-2753	226	20	exclusion	exclusion	NOUN
admet-2753	226	21	membranes	membrane	NOUN
admet-2753	226	22	got	get	VERB
admet-2753	226	23	smaller	small	ADJ
admet-2753	226	24	in	in	ADP
admet-2753	226	25	terms	term	NOUN
admet-2753	226	26	of	of	ADP
admet-2753	226	27	papp	papp	NOUN
admet-2753	226	28	value	value	NOUN
admet-2753	226	29	.	.	PUNCT
admet-2753	227	1	in	in	ADP
admet-2753	227	2	a	a	DET
admet-2753	227	3	non	non	ADJ
admet-2753	227	4	-	-	ADJ
admet-2753	227	5	stirred	stirred	ADJ
admet-2753	227	6	environment	environment	NOUN
admet-2753	227	7	,	,	PUNCT
admet-2753	227	8	where	where	SCONJ
admet-2753	227	9	the	the	DET
admet-2753	227	10	uwl	uwl	NOUN
admet-2753	227	11	is	be	AUX
admet-2753	227	12	the	the	DET
admet-2753	227	13	thickest	thick	ADJ
admet-2753	227	14	,	,	PUNCT
admet-2753	227	15	these	these	DET
admet-2753	227	16	differences	difference	NOUN
admet-2753	227	17	completely	completely	ADV
admet-2753	227	18	disappeared	disappear	VERB
admet-2753	227	19	,	,	PUNCT
admet-2753	227	20	and	and	CCONJ
admet-2753	227	21	in	in	ADP
admet-2753	227	22	the	the	DET
admet-2753	227	23	case	case	NOUN
admet-2753	227	24	of	of	ADP
admet-2753	227	25	all	all	DET
admet-2753	227	26	3	3	NUM
admet-2753	227	27	membranes	membrane	NOUN
admet-2753	227	28	,	,	PUNCT
admet-2753	227	29	similar	similar	ADJ
admet-2753	227	30	papp	papp	NOUN
admet-2753	227	31	values	value	NOUN
admet-2753	227	32	could	could	AUX
admet-2753	227	33	be	be	AUX
admet-2753	227	34	measured	measure	VERB
admet-2753	227	35	.	.	PUNCT
admet-2753	228	1	statistical	statistical	ADJ
admet-2753	228	2	analysis	analysis	NOUN
admet-2753	228	3	(	(	PUNCT
admet-2753	228	4	3way	3way	NOUN
admet-2753	228	5	anova	anova	PROPN
admet-2753	228	6	factorial	factorial	NOUN
admet-2753	228	7	design	design	PROPN
admet-2753	228	8	)	)	PUNCT
admet-2753	228	9	was	be	AUX
admet-2753	228	10	carried	carry	VERB
admet-2753	228	11	out	out	ADP
admet-2753	228	12	for	for	ADP
admet-2753	228	13	the	the	DET
admet-2753	228	14	pm	pm	NOUN
admet-2753	228	15	and	and	CCONJ
admet-2753	228	16	puwl	puwl	ADJ
admet-2753	228	17	values	value	NOUN
admet-2753	228	18	calculated	calculate	VERB
admet-2753	228	19	from	from	ADP
admet-2753	228	20	papp	papp	NOUN
admet-2753	228	21	(	(	PUNCT
admet-2753	228	22	table	table	NOUN
admet-2753	228	23	s2	s2	PROPN
admet-2753	228	24	)	)	PUNCT
admet-2753	228	25	.	.	PUNCT
admet-2753	229	1	the	the	DET
admet-2753	229	2	results	result	NOUN
admet-2753	229	3	of	of	ADP
admet-2753	229	4	the	the	DET
admet-2753	229	5	analysis	analysis	NOUN
admet-2753	229	6	showed	show	VERB
admet-2753	229	7	that	that	SCONJ
admet-2753	229	8	both	both	DET
admet-2753	229	9	main	main	ADJ
admet-2753	229	10	factors	factor	NOUN
admet-2753	229	11	have	have	VERB
admet-2753	229	12	a	a	DET
admet-2753	229	13	significant	significant	ADJ
admet-2753	229	14	effect	effect	NOUN
admet-2753	229	15	on	on	ADP
admet-2753	229	16	the	the	DET
admet-2753	229	17	uwl	uwl	NOUN
admet-2753	229	18	permeability	permeability	NOUN
admet-2753	229	19	(	(	PUNCT
admet-2753	229	20	puwl	puwl	ADV
admet-2753	229	21	):	):	PUNCT
admet-2753	229	22	stirring	stir	VERB
admet-2753	229	23	speed	speed	NOUN
admet-2753	229	24	and	and	CCONJ
admet-2753	229	25	the	the	DET
admet-2753	229	26	presence	presence	NOUN
admet-2753	229	27	of	of	ADP
admet-2753	229	28	hp	hp	PROPN
admet-2753	229	29	-	-	PUNCT
admet-2753	229	30	β	β	NOUN
admet-2753	229	31	-	-	NOUN
admet-2753	229	32	cd	cd	NOUN
admet-2753	229	33	.	.	PUNCT
admet-2753	230	1	the	the	DET
admet-2753	230	2	membrane	membrane	NOUN
admet-2753	230	3	type	type	NOUN
admet-2753	230	4	was	be	AUX
admet-2753	230	5	found	find	VERB
admet-2753	230	6	not	not	PART
admet-2753	230	7	significant	significant	ADJ
admet-2753	230	8	due	due	ADP
admet-2753	230	9	to	to	ADP
admet-2753	230	10	the	the	DET
admet-2753	230	11	assumption	assumption	NOUN
admet-2753	230	12	that	that	PRON
admet-2753	230	13	puwl	puwl	VERB
admet-2753	230	14	,	,	PUNCT
admet-2753	230	15	and	and	CCONJ
admet-2753	230	16	huwl	huwl	NOUN
admet-2753	230	17	is	be	AUX
admet-2753	230	18	the	the	DET
admet-2753	230	19	same	same	ADJ
admet-2753	230	20	for	for	ADP
admet-2753	230	21	different	different	ADJ
admet-2753	230	22	type	type	NOUN
admet-2753	230	23	of	of	ADP
admet-2753	230	24	membranes	membrane	NOUN
admet-2753	230	25	using	use	VERB
admet-2753	230	26	the	the	DET
admet-2753	230	27	same	same	ADJ
admet-2753	230	28	buffer	buffer	NOUN
admet-2753	230	29	composition	composition	NOUN
admet-2753	230	30	and	and	CCONJ
admet-2753	230	31	stirring	stirring	NOUN
admet-2753	230	32	speed	speed	NOUN
admet-2753	230	33	.	.	PUNCT
admet-2753	231	1	in	in	ADP
admet-2753	231	2	the	the	DET
admet-2753	231	3	case	case	NOUN
admet-2753	231	4	of	of	ADP
admet-2753	231	5	pm	pm	NOUN
admet-2753	231	6	data	datum	NOUN
admet-2753	231	7	analysis	analysis	NOUN
admet-2753	231	8	,	,	PUNCT
admet-2753	231	9	the	the	DET
admet-2753	231	10	results	result	NOUN
admet-2753	231	11	showed	show	VERB
admet-2753	231	12	that	that	SCONJ
admet-2753	231	13	the	the	DET
admet-2753	231	14	effect	effect	NOUN
admet-2753	231	15	of	of	ADP
admet-2753	231	16	membrane	membrane	NOUN
admet-2753	231	17	type	type	NOUN
admet-2753	231	18	and	and	CCONJ
admet-2753	231	19	cd	cd	PROPN
admet-2753	231	20	was	be	AUX
admet-2753	231	21	found	find	VERB
admet-2753	231	22	to	to	PART
admet-2753	231	23	be	be	AUX
admet-2753	231	24	significant	significant	ADJ
admet-2753	231	25	.	.	PUNCT
admet-2753	232	1	the	the	DET
admet-2753	232	2	stirring	stir	VERB
admet-2753	232	3	speed	speed	NOUN
admet-2753	232	4	was	be	AUX
admet-2753	232	5	found	find	VERB
admet-2753	232	6	to	to	PART
admet-2753	232	7	be	be	AUX
admet-2753	232	8	non	non	ADJ
admet-2753	232	9	-	-	ADJ
admet-2753	232	10	significant	significant	ADJ
admet-2753	232	11	,	,	PUNCT
admet-2753	232	12	which	which	PRON
admet-2753	232	13	is	be	AUX
admet-2753	232	14	consistent	consistent	ADJ
admet-2753	232	15	with	with	ADP
admet-2753	232	16	the	the	DET
admet-2753	232	17	calculation	calculation	NOUN
admet-2753	232	18	of	of	ADP
admet-2753	232	19	pm	pm	NOUN
admet-2753	232	20	.	.	PUNCT
admet-2753	233	1	pm	pm	PROPN
admet-2753	233	2	was	be	AUX
admet-2753	233	3	found	find	VERB
admet-2753	233	4	significantly	significantly	ADV
admet-2753	233	5	higher	high	ADJ
admet-2753	233	6	in	in	ADP
admet-2753	233	7	the	the	DET
admet-2753	233	8	case	case	NOUN
admet-2753	233	9	of	of	ADP
admet-2753	233	10	lipophilic	lipophilic	ADJ
admet-2753	233	11	membranes	membrane	NOUN
admet-2753	233	12	than	than	ADP
admet-2753	233	13	in	in	ADP
admet-2753	233	14	the	the	DET
admet-2753	233	15	case	case	NOUN
admet-2753	233	16	of	of	ADP
admet-2753	233	17	the	the	DET
admet-2753	233	18	size	size	NOUN
admet-2753	233	19	-	-	PUNCT
admet-2753	233	20	exclusion	exclusion	NOUN
admet-2753	233	21	membranes	membrane	NOUN
admet-2753	233	22	,	,	PUNCT
admet-2753	233	23	which	which	PRON
admet-2753	233	24	is	be	AUX
admet-2753	233	25	reasonable	reasonable	ADJ
admet-2753	233	26	considering	consider	VERB
admet-2753	233	27	that	that	SCONJ
admet-2753	233	28	the	the	DET
admet-2753	233	29	lipophilic	lipophilic	ADJ
admet-2753	233	30	drug	drug	NOUN
admet-2753	233	31	diffuses	diffuse	VERB
admet-2753	233	32	faster	fast	ADV
admet-2753	233	33	in	in	ADP
admet-2753	233	34	a	a	DET
admet-2753	233	35	lipophilic	lipophilic	ADJ
admet-2753	233	36	environment	environment	NOUN
admet-2753	233	37	.	.	PUNCT
admet-2753	234	1	there	there	PRON
admet-2753	234	2	was	be	VERB
admet-2753	234	3	no	no	DET
admet-2753	234	4	significant	significant	ADJ
admet-2753	234	5	difference	difference	NOUN
admet-2753	234	6	between	between	ADP
admet-2753	234	7	the	the	DET
admet-2753	234	8	pm	pm	NOUN
admet-2753	234	9	values	value	NOUN
admet-2753	234	10	measured	measure	VERB
admet-2753	234	11	for	for	ADP
admet-2753	234	12	the	the	DET
admet-2753	234	13	different	different	ADJ
admet-2753	234	14	mwco	mwco	NOUN
admet-2753	234	15	membranes	membrane	NOUN
admet-2753	234	16	.	.	PUNCT
admet-2753	235	1	placing	place	VERB
admet-2753	235	2	hp	hp	PROPN
admet-2753	235	3	-	-	PUNCT
admet-2753	235	4	β	β	NOUN
admet-2753	235	5	-	-	NOUN
admet-2753	235	6	cd	cd	NOUN
admet-2753	235	7	in	in	ADP
admet-2753	235	8	the	the	DET
admet-2753	235	9	donor	donor	NOUN
admet-2753	235	10	compartment	compartment	NOUN
admet-2753	235	11	caused	cause	VERB
admet-2753	235	12	the	the	DET
admet-2753	235	13	pm	pm	NOUN
admet-2753	235	14	value	value	NOUN
admet-2753	235	15	to	to	PART
admet-2753	235	16	decrease	decrease	VERB
admet-2753	235	17	in	in	ADP
admet-2753	235	18	all	all	DET
admet-2753	235	19	membrane	membrane	NOUN
admet-2753	235	20	types	type	NOUN
admet-2753	235	21	.	.	PUNCT
admet-2753	236	1	p	p	X
admet-2753	236	2	a	a	DET
admet-2753	236	3	p	p	X
admet-2753	236	4	p	p	X
admet-2753	236	5	/	/	SYM
admet-2753	236	6	c	c	NOUN
admet-2753	236	7	m	m	NOUN
admet-2753	236	8	s	s	NOUN
admet-2753	236	9	-1	-1	NOUN
admet-2753	236	10	p	p	X
admet-2753	236	11	a	a	DET
admet-2753	236	12	p	p	X
admet-2753	236	13	p	p	X
admet-2753	236	14	/	/	SYM
admet-2753	236	15	c	c	NOUN
admet-2753	236	16	m	m	NOUN
admet-2753	236	17	s	s	NOUN
admet-2753	236	18	-1	-1	NOUN
admet-2753	236	19	p	p	X
admet-2753	236	20	a	a	DET
admet-2753	236	21	p	p	X
admet-2753	236	22	p	p	X
admet-2753	236	23	/	/	SYM
admet-2753	236	24	c	c	NOUN
admet-2753	236	25	m	m	NOUN
admet-2753	236	26	s	s	NOUN
admet-2753	236	27	-1	-1	NOUN
admet-2753	236	28	p	p	X
admet-2753	236	29	a	a	DET
admet-2753	236	30	p	p	X
admet-2753	236	31	p	p	X
admet-2753	236	32	/	/	SYM
admet-2753	236	33	c	c	NOUN
admet-2753	236	34	m	m	NOUN
admet-2753	236	35	s	s	NOUN
admet-2753	236	36	-1	-1	NOUN
admet-2753	236	37	p	p	X
admet-2753	236	38	a	a	DET
admet-2753	236	39	p	p	X
admet-2753	236	40	p	p	X
admet-2753	236	41	/	/	SYM
admet-2753	236	42	c	c	NOUN
admet-2753	236	43	m	m	NOUN
admet-2753	236	44	s	s	NOUN
admet-2753	236	45	-1	-1	NOUN
admet-2753	236	46	p	p	X
admet-2753	236	47	a	a	DET
admet-2753	236	48	p	p	X
admet-2753	236	49	p	p	X
admet-2753	236	50	/	/	SYM
admet-2753	236	51	c	c	NOUN
admet-2753	236	52	m	m	NOUN
admet-2753	236	53	s	s	NOUN
admet-2753	236	54	-1	-1	NOUN
admet-2753	236	55	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	236	56	p.	p.	PROPN
admet-2753	236	57	tőzsér	tőzsér	PROPN
admet-2753	236	58	et	et	PROPN
admet-2753	236	59	al	al	PROPN
admet-2753	236	60	.	.	PROPN
admet-2753	236	61	admet	admet	PROPN
admet-2753	236	62	&	&	CCONJ
admet-2753	236	63	dmpk	dmpk	PROPN
admet-2753	236	64	13(4	13(4	NUM
admet-2753	236	65	)	)	PUNCT
admet-2753	236	66	(	(	PUNCT
admet-2753	236	67	2025	2025	NUM
admet-2753	236	68	)	)	PUNCT
admet-2753	236	69	2753	2753	NUM
admet-2753	236	70	14	14	NUM
admet-2753	236	71	in	in	ADP
admet-2753	236	72	conclusion	conclusion	NOUN
admet-2753	236	73	,	,	PUNCT
admet-2753	236	74	using	use	VERB
admet-2753	236	75	a	a	DET
admet-2753	236	76	non	non	ADJ
admet-2753	236	77	-	-	ADJ
admet-2753	236	78	stirred	stirred	ADJ
admet-2753	236	79	environment	environment	NOUN
admet-2753	236	80	caused	cause	VERB
admet-2753	236	81	the	the	DET
admet-2753	236	82	absolute	absolute	ADJ
admet-2753	236	83	papp	papp	NOUN
admet-2753	236	84	values	value	NOUN
admet-2753	236	85	to	to	PART
admet-2753	236	86	be	be	AUX
admet-2753	236	87	similar	similar	ADJ
admet-2753	236	88	in	in	ADP
admet-2753	236	89	the	the	DET
admet-2753	236	90	case	case	NOUN
admet-2753	236	91	of	of	ADP
admet-2753	236	92	all	all	DET
admet-2753	236	93	three	three	NUM
admet-2753	236	94	membranes	membrane	NOUN
admet-2753	236	95	.	.	PUNCT
admet-2753	237	1	however	however	ADV
admet-2753	237	2	,	,	PUNCT
admet-2753	237	3	since	since	SCONJ
admet-2753	237	4	non	non	ADJ
admet-2753	237	5	-	-	ADJ
admet-2753	237	6	stirring	stirring	ADJ
admet-2753	237	7	significantly	significantly	ADV
admet-2753	237	8	reduces	reduce	VERB
admet-2753	237	9	the	the	DET
admet-2753	237	10	effect	effect	NOUN
admet-2753	237	11	of	of	ADP
admet-2753	237	12	solubilizing	solubilize	VERB
admet-2753	237	13	agents	agent	NOUN
admet-2753	237	14	for	for	ADP
admet-2753	237	15	all	all	DET
admet-2753	237	16	three	three	NUM
admet-2753	237	17	membranes	membrane	NOUN
admet-2753	237	18	,	,	PUNCT
admet-2753	237	19	stirring	stirring	NOUN
admet-2753	237	20	is	be	AUX
admet-2753	237	21	essential	essential	ADJ
admet-2753	237	22	to	to	PART
admet-2753	237	23	observe	observe	VERB
admet-2753	237	24	excipient	excipient	ADJ
admet-2753	237	25	effects	effect	NOUN
admet-2753	237	26	reliably	reliably	ADV
admet-2753	237	27	.	.	PUNCT
admet-2753	238	1	therefore	therefore	ADV
admet-2753	238	2	,	,	PUNCT
admet-2753	238	3	stirring	stir	VERB
admet-2753	238	4	remains	remain	VERB
admet-2753	238	5	crucial	crucial	ADJ
admet-2753	238	6	for	for	ADP
admet-2753	238	7	assessing	assess	VERB
admet-2753	238	8	the	the	DET
admet-2753	238	9	impact	impact	NOUN
admet-2753	238	10	of	of	ADP
admet-2753	238	11	formulation	formulation	NOUN
admet-2753	238	12	additives	additive	NOUN
admet-2753	238	13	on	on	ADP
admet-2753	238	14	apparent	apparent	ADJ
admet-2753	238	15	permeability	permeability	NOUN
admet-2753	238	16	and	and	CCONJ
admet-2753	238	17	for	for	ADP
admet-2753	238	18	the	the	DET
admet-2753	238	19	comparison	comparison	NOUN
admet-2753	238	20	of	of	ADP
admet-2753	238	21	different	different	ADJ
admet-2753	238	22	drug	drug	NOUN
admet-2753	238	23	formulations	formulation	NOUN
admet-2753	238	24	containing	contain	VERB
admet-2753	238	25	the	the	DET
admet-2753	238	26	same	same	ADJ
admet-2753	238	27	api	api	NOUN
admet-2753	238	28	.	.	PUNCT
admet-2753	239	1	mathematical	mathematical	ADJ
admet-2753	239	2	description	description	NOUN
admet-2753	239	3	of	of	ADP
admet-2753	239	4	membrane	membrane	NOUN
admet-2753	239	5	transport	transport	NOUN
admet-2753	239	6	in	in	ADP
admet-2753	239	7	uwl	uwl	NOUN
admet-2753	239	8	limited	limit	VERB
admet-2753	239	9	case	case	NOUN
admet-2753	239	10	in	in	ADP
admet-2753	239	11	this	this	DET
admet-2753	239	12	section	section	NOUN
admet-2753	239	13	of	of	ADP
admet-2753	239	14	the	the	DET
admet-2753	239	15	study	study	NOUN
admet-2753	240	1	,	,	PUNCT
admet-2753	240	2	the	the	DET
admet-2753	240	3	aim	aim	NOUN
admet-2753	240	4	was	be	AUX
admet-2753	240	5	to	to	PART
admet-2753	240	6	mathematically	mathematically	ADV
admet-2753	240	7	describe	describe	VERB
admet-2753	240	8	the	the	DET
admet-2753	240	9	transport	transport	NOUN
admet-2753	240	10	through	through	ADP
admet-2753	240	11	the	the	DET
admet-2753	240	12	uwlmembrane	uwlmembrane	NOUN
admet-2753	240	13	-	-	PUNCT
admet-2753	240	14	uwl	uwl	NOUN
admet-2753	240	15	system	system	NOUN
admet-2753	240	16	in	in	ADP
admet-2753	240	17	a	a	DET
admet-2753	240	18	general	general	ADJ
admet-2753	240	19	manner	manner	NOUN
admet-2753	240	20	,	,	PUNCT
admet-2753	240	21	without	without	ADP
admet-2753	240	22	specifying	specify	VERB
admet-2753	240	23	the	the	DET
admet-2753	240	24	type	type	NOUN
admet-2753	240	25	of	of	ADP
admet-2753	240	26	membrane	membrane	NOUN
admet-2753	240	27	between	between	ADP
admet-2753	240	28	the	the	DET
admet-2753	240	29	two	two	NUM
admet-2753	240	30	uwl	uwl	NOUN
admet-2753	240	31	layers	layer	NOUN
admet-2753	240	32	or	or	CCONJ
admet-2753	240	33	whether	whether	SCONJ
admet-2753	240	34	the	the	DET
admet-2753	240	35	transport	transport	NOUN
admet-2753	240	36	-	-	PUNCT
admet-2753	240	37	limiting	limit	VERB
admet-2753	240	38	step	step	NOUN
admet-2753	240	39	is	be	AUX
admet-2753	240	40	access	access	NOUN
admet-2753	240	41	through	through	ADP
admet-2753	240	42	the	the	DET
admet-2753	240	43	uwl	uwl	NOUN
admet-2753	240	44	.	.	PUNCT
admet-2753	241	1	therefore	therefore	ADV
admet-2753	241	2	,	,	PUNCT
admet-2753	241	3	we	we	PRON
admet-2753	241	4	assumed	assume	VERB
admet-2753	241	5	that	that	SCONJ
admet-2753	241	6	the	the	DET
admet-2753	241	7	transport	transport	NOUN
admet-2753	241	8	through	through	ADP
admet-2753	241	9	the	the	DET
admet-2753	241	10	membrane	membrane	NOUN
admet-2753	241	11	can	can	AUX
admet-2753	241	12	be	be	AUX
admet-2753	241	13	neglected	neglect	VERB
admet-2753	241	14	,	,	PUNCT
admet-2753	241	15	and	and	CCONJ
admet-2753	241	16	only	only	ADV
admet-2753	241	17	a	a	DET
admet-2753	241	18	double	double	ADJ
admet-2753	241	19	-	-	PUNCT
admet-2753	241	20	size	size	NOUN
admet-2753	241	21	uwl	uwl	NOUN
admet-2753	241	22	serves	serve	VERB
admet-2753	241	23	as	as	ADP
admet-2753	241	24	a	a	DET
admet-2753	241	25	barrier	barrier	NOUN
admet-2753	241	26	for	for	SCONJ
admet-2753	241	27	the	the	DET
admet-2753	241	28	api	api	NOUN
admet-2753	241	29	to	to	PART
admet-2753	241	30	diffuse	diffuse	VERB
admet-2753	241	31	from	from	ADP
admet-2753	241	32	the	the	DET
admet-2753	241	33	donor	donor	NOUN
admet-2753	241	34	to	to	ADP
admet-2753	241	35	the	the	DET
admet-2753	241	36	acceptor	acceptor	NOUN
admet-2753	241	37	compartment	compartment	NOUN
admet-2753	241	38	(	(	PUNCT
admet-2753	241	39	figure	figure	NOUN
admet-2753	241	40	9	9	NUM
admet-2753	241	41	)	)	PUNCT
admet-2753	241	42	.	.	PUNCT
admet-2753	242	1	later	later	ADV
admet-2753	242	2	in	in	ADP
admet-2753	242	3	the	the	DET
admet-2753	242	4	article	article	NOUN
admet-2753	242	5	,	,	PUNCT
admet-2753	242	6	the	the	DET
admet-2753	242	7	applicability	applicability	NOUN
admet-2753	242	8	of	of	ADP
admet-2753	242	9	such	such	DET
admet-2753	242	10	a	a	DET
admet-2753	242	11	simplified	simplified	ADJ
admet-2753	242	12	model	model	NOUN
admet-2753	242	13	will	will	AUX
admet-2753	242	14	be	be	AUX
admet-2753	242	15	discussed	discuss	VERB
admet-2753	242	16	.	.	PUNCT
admet-2753	243	1	figure	figure	NOUN
admet-2753	243	2	9	9	NUM
admet-2753	243	3	.	.	PUNCT
admet-2753	243	4	simplified	simplify	VERB
admet-2753	243	5	transport	transport	NOUN
admet-2753	243	6	model	model	NOUN
admet-2753	243	7	for	for	ADP
admet-2753	243	8	uwl	uwl	X
admet-2753	243	9	limited	limit	VERB
admet-2753	243	10	cases	case	NOUN
admet-2753	243	11	transport	transport	NOUN
admet-2753	243	12	of	of	ADP
admet-2753	243	13	the	the	DET
admet-2753	243	14	pure	pure	ADJ
admet-2753	243	15	api	api	NOUN
admet-2753	243	16	through	through	ADP
admet-2753	243	17	the	the	DET
admet-2753	243	18	uwl	uwl	NOUN
admet-2753	243	19	the	the	DET
admet-2753	243	20	transport	transport	NOUN
admet-2753	243	21	of	of	ADP
admet-2753	243	22	the	the	DET
admet-2753	243	23	pure	pure	ADJ
admet-2753	243	24	api	api	NOUN
admet-2753	243	25	through	through	ADP
admet-2753	243	26	the	the	DET
admet-2753	243	27	uwl	uwl	NOUN
admet-2753	243	28	is	be	AUX
admet-2753	243	29	most	most	ADV
admet-2753	243	30	commonly	commonly	ADV
admet-2753	243	31	described	describe	VERB
admet-2753	243	32	by	by	ADP
admet-2753	243	33	fick	fick	PROPN
admet-2753	243	34	’s	’s	PART
admet-2753	243	35	first	first	ADJ
admet-2753	243	36	law	law	NOUN
admet-2753	243	37	of	of	ADP
admet-2753	243	38	diffusion	diffusion	NOUN
admet-2753	243	39	(	(	PUNCT
admet-2753	243	40	equation	equation	NOUN
admet-2753	243	41	(	(	PUNCT
admet-2753	243	42	13	13	NUM
admet-2753	243	43	)	)	PUNCT
admet-2753	243	44	):	):	PUNCT
admet-2753	243	45	0	0	X
admet-2753	244	1	uwl	uwl	X
admet-2753	244	2	uwl	uwl	X
admet-2753	244	3	uwl	uwl	AUX
admet-2753	244	4	uwl	uwl	AUX
admet-2753	244	5	uwl	uwl	AUX
admet-2753	245	1	d	d	NOUN
admet-2753	245	2	  	  	SPACE
admet-2753	245	3	d	d	X
admet-2753	245	4	hc	hc	PROPN
admet-2753	245	5	c	c	NOUN
admet-2753	245	6	c	c	NOUN
admet-2753	245	7	j	j	PROPN
admet-2753	245	8	d	d	X
admet-2753	245	9	d	d	X
admet-2753	245	10	x	x	NOUN
admet-2753	245	11	h	h	NOUN
admet-2753	245	12	−	−	PROPN
admet-2753	245	13	=	=	PUNCT
admet-2753	246	1	=	=	SYM
admet-2753	246	2	(	(	PUNCT
admet-2753	246	3	13	13	NUM
admet-2753	246	4	)	)	PUNCT
admet-2753	246	5	where	where	SCONJ
admet-2753	246	6	j	j	PROPN
admet-2753	246	7	is	be	AUX
admet-2753	246	8	the	the	DET
admet-2753	246	9	flux	flux	NOUN
admet-2753	246	10	,	,	PUNCT
admet-2753	246	11	duwl	duwl	NOUN
admet-2753	246	12	is	be	AUX
admet-2753	246	13	the	the	DET
admet-2753	246	14	diffusion	diffusion	NOUN
admet-2753	246	15	coefficient	coefficient	NOUN
admet-2753	246	16	through	through	ADP
admet-2753	246	17	the	the	DET
admet-2753	246	18	uwl	uwl	NOUN
admet-2753	246	19	,	,	PUNCT
admet-2753	246	20	c0	c0	PROPN
admet-2753	246	21	uwl	uwl	PROPN
admet-2753	246	22	and	and	CCONJ
admet-2753	246	23	ch	ch	PROPN
admet-2753	246	24	uwl	uwl	PROPN
admet-2753	246	25	are	be	AUX
admet-2753	246	26	the	the	DET
admet-2753	246	27	concentration	concentration	NOUN
admet-2753	246	28	of	of	ADP
admet-2753	246	29	non	non	ADJ
admet-2753	246	30	-	-	ADJ
admet-2753	246	31	ionized	ionized	ADJ
admet-2753	246	32	molecules	molecule	NOUN
admet-2753	246	33	on	on	ADP
admet-2753	246	34	both	both	DET
admet-2753	246	35	sides	side	NOUN
admet-2753	246	36	of	of	ADP
admet-2753	246	37	the	the	DET
admet-2753	246	38	uwl	uwl	NOUN
admet-2753	246	39	and	and	CCONJ
admet-2753	246	40	h	h	NOUN
admet-2753	246	41	is	be	AUX
admet-2753	246	42	the	the	DET
admet-2753	246	43	thickness	thickness	NOUN
admet-2753	246	44	of	of	ADP
admet-2753	246	45	the	the	DET
admet-2753	246	46	water	water	NOUN
admet-2753	246	47	layer	layer	NOUN
admet-2753	246	48	.	.	PUNCT
admet-2753	247	1	considering	consider	VERB
admet-2753	247	2	the	the	DET
admet-2753	247	3	partitioning	partitioning	NOUN
admet-2753	247	4	between	between	ADP
admet-2753	247	5	the	the	DET
admet-2753	247	6	uwl	uwl	NOUN
admet-2753	247	7	and	and	CCONJ
admet-2753	247	8	the	the	DET
admet-2753	247	9	bulk	bulk	NOUN
admet-2753	247	10	of	of	ADP
admet-2753	247	11	the	the	DET
admet-2753	247	12	donor	donor	NOUN
admet-2753	247	13	solution	solution	NOUN
admet-2753	247	14	and	and	CCONJ
admet-2753	247	15	acceptor	acceptor	NOUN
admet-2753	247	16	solution	solution	NOUN
admet-2753	247	17	,	,	PUNCT
admet-2753	247	18	equations	equation	NOUN
admet-2753	247	19	(	(	PUNCT
admet-2753	247	20	14	14	NUM
admet-2753	247	21	)	)	PUNCT
admet-2753	247	22	and	and	CCONJ
admet-2753	247	23	(	(	PUNCT
admet-2753	247	24	15	15	NUM
admet-2753	247	25	):	):	PUNCT
admet-2753	247	26	0	0	NUM
admet-2753	247	27	uwl	uwl	X
admet-2753	247	28	uwl	uwl	AUX
admet-2753	247	29	d1	d1	VERB
admet-2753	247	30	0	0	PUNCT
admet-2753	248	1	d	d	NOUN
admet-2753	248	2	d	d	X
admet-2753	248	3	*	*	PUNCT
admet-2753	248	4	  	  	SPACE
admet-2753	248	5	*	*	PUNCT
admet-2753	249	1	c	c	NOUN
admet-2753	249	2	c	c	X
admet-2753	250	1	k	k	NOUN
admet-2753	250	2	c	c	NOUN
admet-2753	250	3	c	c	NOUN
admet-2753	250	4	=	=	PUNCT
admet-2753	251	1	=	=	SYM
admet-2753	251	2	=	=	SYM
admet-2753	251	3	(	(	PUNCT
admet-2753	251	4	14	14	NUM
admet-2753	251	5	)	)	PUNCT
admet-2753	251	6	uwl	uwl	AUX
admet-2753	251	7	uwl	uwl	AUX
admet-2753	251	8	d2	d2	VERB
admet-2753	251	9	a	a	DET
admet-2753	251	10	a	a	NOUN
admet-2753	251	11	*	*	PUNCT
admet-2753	251	12	  	  	SPACE
admet-2753	251	13	*	*	PUNCT
admet-2753	251	14	hc	hc	PRON
admet-2753	252	1	c	c	NOUN
admet-2753	252	2	k	k	NOUN
admet-2753	252	3	c	c	NOUN
admet-2753	252	4	c	c	NOUN
admet-2753	252	5	=	=	PUNCT
admet-2753	253	1	=	=	PUNCT
admet-2753	253	2	=	=	SYM
admet-2753	253	3	  	  	SPACE
admet-2753	253	4	(	(	PUNCT
admet-2753	253	5	15	15	NUM
admet-2753	253	6	)	)	PUNCT
admet-2753	253	7	where	where	SCONJ
admet-2753	253	8	kd1	kd1	PROPN
admet-2753	253	9	and	and	CCONJ
admet-2753	253	10	kd2	kd2	PROPN
admet-2753	253	11	are	be	AUX
admet-2753	253	12	partition	partition	NOUN
admet-2753	253	13	coefficients	coefficient	NOUN
admet-2753	253	14	for	for	ADP
admet-2753	253	15	steady	steady	ADJ
admet-2753	253	16	state	state	NOUN
admet-2753	253	17	,	,	PUNCT
admet-2753	253	18	cd	cd	PROPN
admet-2753	253	19	and	and	CCONJ
admet-2753	253	20	ca	can	AUX
admet-2753	253	21	are	be	AUX
admet-2753	253	22	concentrations	concentration	NOUN
admet-2753	253	23	on	on	ADP
admet-2753	253	24	the	the	DET
admet-2753	253	25	donor	donor	NOUN
admet-2753	253	26	and	and	CCONJ
admet-2753	253	27	the	the	DET
admet-2753	253	28	acceptor	acceptor	NOUN
admet-2753	253	29	side	side	NOUN
admet-2753	253	30	,	,	PUNCT
admet-2753	253	31	*	*	PUNCT
admet-2753	253	32	is	be	AUX
admet-2753	253	33	the	the	DET
admet-2753	253	34	property	property	NOUN
admet-2753	253	35	at	at	ADP
admet-2753	253	36	saturation	saturation	NOUN
admet-2753	253	37	.	.	PUNCT
admet-2753	254	1	based	base	VERB
admet-2753	254	2	on	on	ADP
admet-2753	254	3	equations	equation	NOUN
admet-2753	254	4	(	(	PUNCT
admet-2753	254	5	14	14	NUM
admet-2753	254	6	)	)	PUNCT
admet-2753	254	7	and	and	CCONJ
admet-2753	254	8	(	(	PUNCT
admet-2753	254	9	15	15	X
admet-2753	254	10	)	)	PUNCT
admet-2753	254	11	c0	c0	PROPN
admet-2753	254	12	uwl	uwl	PROPN
admet-2753	254	13	and	and	CCONJ
admet-2753	254	14	ch	ch	PROPN
admet-2753	254	15	uwl	uwl	PROPN
admet-2753	254	16	can	can	AUX
admet-2753	254	17	be	be	AUX
admet-2753	254	18	expressed	express	VERB
admet-2753	254	19	as	as	ADP
admet-2753	254	20	:	:	PUNCT
admet-2753	254	21	0	0	NUM
admet-2753	254	22	uwl	uwl	SYM
admet-2753	254	23	uwl	uwl	PROPN
admet-2753	255	1	d	d	NOUN
admet-2753	255	2	d	d	X
admet-2753	255	3	*	*	PUNCT
admet-2753	255	4	*	*	PUNCT
admet-2753	256	1	c	c	NOUN
admet-2753	256	2	c	c	NOUN
admet-2753	256	3	c	c	NOUN
admet-2753	256	4	c	c	NOUN
admet-2753	256	5	=	=	SYM
admet-2753	256	6	(	(	PUNCT
admet-2753	256	7	16	16	NUM
admet-2753	256	8	)	)	PUNCT
admet-2753	256	9	c0	c0	PROPN
admet-2753	256	10	uwl	uwl	X
admet-2753	256	11	0	0	NUM
admet-2753	256	12	m	m	VERB
admet-2753	256	13	m	m	VERB
admet-2753	256	14	hmc	hmc	NOUN
admet-2753	256	15	x	x	X
admet-2753	256	16	c	c	X
admet-2753	256	17	⎯⎯⎯⎯⎯→	⎯⎯⎯⎯⎯→	X
admet-2753	256	18	ch	ch	PROPN
admet-2753	256	19	uwl	uwl	PROPN
admet-2753	256	20	admet	admet	PROPN
admet-2753	256	21	&	&	CCONJ
admet-2753	256	22	dmpk	dmpk	PROPN
admet-2753	256	23	13(4	13(4	NUM
admet-2753	256	24	)	)	PUNCT
admet-2753	256	25	(	(	PUNCT
admet-2753	256	26	2025	2025	NUM
admet-2753	256	27	)	)	PUNCT
admet-2753	256	28	2753	2753	NUM
admet-2753	256	29	comparison	comparison	NOUN
admet-2753	256	30	of	of	ADP
admet-2753	256	31	lipophilic	lipophilic	ADJ
admet-2753	256	32	and	and	CCONJ
admet-2753	256	33	size	size	NOUN
admet-2753	256	34	-	-	PUNCT
admet-2753	256	35	exclusion	exclusion	NOUN
admet-2753	256	36	membranes	membrane	NOUN
admet-2753	256	37	doi	doi	NOUN
admet-2753	256	38	:	:	PUNCT
admet-2753	256	39	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	256	40	15	15	NUM
admet-2753	256	41	uwl	uwl	X
admet-2753	256	42	uwl	uwl	AUX
admet-2753	256	43	a	a	PRON
admet-2753	256	44	a	a	X
admet-2753	256	45	*	*	X
admet-2753	257	1	*	*	PUNCT
admet-2753	257	2	h	h	NOUN
admet-2753	258	1	c	c	NOUN
admet-2753	258	2	c	c	NOUN
admet-2753	258	3	c	c	NOUN
admet-2753	258	4	c	c	NOUN
admet-2753	258	5	=	=	SYM
admet-2753	258	6	(	(	PUNCT
admet-2753	258	7	17	17	NUM
admet-2753	258	8	)	)	PUNCT
admet-2753	258	9	if	if	SCONJ
admet-2753	258	10	equations	equation	NOUN
admet-2753	258	11	(	(	PUNCT
admet-2753	258	12	16	16	NUM
admet-2753	258	13	)	)	PUNCT
admet-2753	258	14	and	and	CCONJ
admet-2753	258	15	(	(	PUNCT
admet-2753	258	16	17	17	NUM
admet-2753	258	17	)	)	PUNCT
admet-2753	258	18	are	be	AUX
admet-2753	258	19	substituted	substitute	VERB
admet-2753	258	20	into	into	ADP
admet-2753	258	21	equation	equation	NOUN
admet-2753	258	22	(	(	PUNCT
admet-2753	258	23	13	13	NUM
admet-2753	258	24	)	)	PUNCT
admet-2753	258	25	,	,	PUNCT
admet-2753	258	26	then	then	ADV
admet-2753	258	27	equation	equation	NOUN
admet-2753	258	28	(	(	PUNCT
admet-2753	258	29	18	18	NUM
admet-2753	258	30	)	)	PUNCT
admet-2753	258	31	is	be	AUX
admet-2753	258	32	obtained	obtain	VERB
admet-2753	258	33	:	:	PUNCT
admet-2753	258	34	(	(	PUNCT
admet-2753	258	35	)	)	PUNCT
admet-2753	258	36	0uwl	0uwl	X
admet-2753	258	37	uwl	uwl	X
admet-2753	258	38	uwl	uwl	X
admet-2753	258	39	uwl	uwl	AUX
admet-2753	258	40	uwl	uwl	AUX
admet-2753	258	41	uwl	uwl	AUX
admet-2753	259	1	d	d	VERB
admet-2753	259	2	a	a	DET
admet-2753	259	3	uwl	uwl	X
admet-2753	259	4	uwl	uwl	NOUN
admet-2753	260	1	d	d	NOUN
admet-2753	260	2	a	a	X
admet-2753	260	3	d	d	X
admet-2753	260	4	a	a	PROPN
admet-2753	260	5	d	d	NOUN
admet-2753	260	6	a	a	PROPN
admet-2753	260	7	*	*	PUNCT
admet-2753	261	1	*	*	PUNCT
admet-2753	261	2	*	*	PUNCT
admet-2753	261	3	      	      	SPACE
admet-2753	262	1	*	*	PUNCT
admet-2753	263	1	*	*	PUNCT
admet-2753	263	2	*	*	PUNCT
admet-2753	263	3	*	*	PUNCT
admet-2753	263	4	hd	hd	PROPN
admet-2753	263	5	d	d	NOUN
admet-2753	263	6	c	c	NOUN
admet-2753	263	7	c	c	PROPN
admet-2753	263	8	d	d	NOUN
admet-2753	263	9	c	c	NOUN
admet-2753	263	10	c	c	NOUN
admet-2753	263	11	c	c	NOUN
admet-2753	263	12	j	j	PROPN
admet-2753	263	13	c	c	NOUN
admet-2753	263	14	c	c	NOUN
admet-2753	263	15	c	c	NOUN
admet-2753	263	16	c	c	NOUN
admet-2753	263	17	h	h	NOUN
admet-2753	263	18	h	h	NOUN
admet-2753	264	1	c	c	NOUN
admet-2753	264	2	c	c	NOUN
admet-2753	265	1	h	h	NOUN
admet-2753	265	2	c	c	NOUN
admet-2753	265	3	c	c	PROPN
admet-2753	265	4			NOUN
admet-2753	265	5			NOUN
admet-2753	265	6			NOUN
admet-2753	265	7			NOUN
admet-2753	265	8	=	=	PUNCT
admet-2753	266	1	−	−	PROPN
admet-2753	266	2	=	=	SYM
admet-2753	267	1	−	−	PROPN
admet-2753	267	2	=	=	SYM
admet-2753	268	1	−	−	PROPN
admet-2753	268	2			PROPN
admet-2753	269	1			PROPN
admet-2753	269	2			PROPN
admet-2753	270	1			ADJ
admet-2753	270	2			PROPN
admet-2753	270	3			PROPN
admet-2753	270	4			NOUN
admet-2753	270	5	(	(	PUNCT
admet-2753	270	6	18	18	NUM
admet-2753	270	7	)	)	PUNCT
admet-2753	270	8	duwl	duwl	NOUN
admet-2753	270	9	,	,	PUNCT
admet-2753	270	10	h	h	NOUN
admet-2753	270	11	,	,	PUNCT
admet-2753	270	12	c*d	c*d	NOUN
admet-2753	270	13	and	and	CCONJ
admet-2753	270	14	c*a	c*a	PROPN
admet-2753	270	15	are	be	AUX
admet-2753	270	16	constants	constant	NOUN
admet-2753	270	17	specific	specific	ADJ
admet-2753	270	18	to	to	ADP
admet-2753	270	19	the	the	DET
admet-2753	270	20	api	api	NOUN
admet-2753	270	21	.	.	PUNCT
admet-2753	271	1	transport	transport	NOUN
admet-2753	271	2	of	of	ADP
admet-2753	271	3	an	an	DET
admet-2753	271	4	api	api	NOUN
admet-2753	271	5	in	in	ADP
admet-2753	271	6	the	the	DET
admet-2753	271	7	presence	presence	NOUN
admet-2753	271	8	of	of	ADP
admet-2753	271	9	solubilizing	solubilize	VERB
admet-2753	271	10	additive	additive	NOUN
admet-2753	271	11	the	the	DET
admet-2753	271	12	starting	starting	NOUN
admet-2753	271	13	equation	equation	NOUN
admet-2753	271	14	is	be	AUX
admet-2753	271	15	equation	equation	NOUN
admet-2753	271	16	(	(	PUNCT
admet-2753	271	17	18	18	NUM
admet-2753	271	18	)	)	PUNCT
admet-2753	271	19	.	.	PUNCT
admet-2753	272	1	duwl	duwl	PROPN
admet-2753	272	2	can	can	AUX
admet-2753	272	3	be	be	AUX
admet-2753	272	4	expressed	express	VERB
admet-2753	272	5	as	as	SCONJ
admet-2753	272	6	shown	show	VERB
admet-2753	272	7	in	in	ADP
admet-2753	272	8	equation	equation	NOUN
admet-2753	272	9	(	(	PUNCT
admet-2753	272	10	12	12	NUM
admet-2753	272	11	)	)	PUNCT
admet-2753	273	1	[	[	X
admet-2753	273	2	60,61	60,61	NOUN
admet-2753	273	3	]	]	PUNCT
admet-2753	273	4	:	:	PUNCT
admet-2753	273	5	duwl	duwl	NOUN
admet-2753	273	6	=	=	SYM
admet-2753	273	7	fu	fu	PROPN
admet-2753	273	8	duwl	duwl	PROPN
admet-2753	273	9	.	.	PUNCT
admet-2753	274	1	mono	mono	PROPN
admet-2753	274	2	+	+	CCONJ
admet-2753	274	3	fcomplex	fcomplex	PROPN
admet-2753	274	4	duwl	duwl	PROPN
admet-2753	274	5	.	.	PUNCT
admet-2753	275	1	complex	complex	ADJ
admet-2753	275	2	(	(	PUNCT
admet-2753	275	3	12	12	NUM
admet-2753	275	4	)	)	PUNCT
admet-2753	275	5	where	where	SCONJ
admet-2753	275	6	fu	fu	NOUN
admet-2753	275	7	and	and	CCONJ
admet-2753	275	8	fcomplex	fcomplex	PROPN
admet-2753	275	9	(	(	PUNCT
admet-2753	275	10	fu	fu	NOUN
admet-2753	275	11	+	+	CCONJ
admet-2753	275	12	fcomplex	fcomplex	NOUN
admet-2753	275	13	=	=	SYM
admet-2753	275	14	1	1	NUM
admet-2753	275	15	)	)	PUNCT
admet-2753	275	16	are	be	AUX
admet-2753	275	17	the	the	DET
admet-2753	275	18	fractions	fraction	NOUN
admet-2753	275	19	of	of	ADP
admet-2753	275	20	the	the	DET
admet-2753	275	21	unbound	unbound	NOUN
admet-2753	275	22	monomer	monomer	NOUN
admet-2753	275	23	and	and	CCONJ
admet-2753	275	24	complexed	complexe	VERB
admet-2753	275	25	api	api	NOUN
admet-2753	275	26	,	,	PUNCT
admet-2753	275	27	respectively	respectively	ADV
admet-2753	275	28	.	.	PUNCT
admet-2753	276	1	the	the	DET
admet-2753	276	2	fu	fu	NOUN
admet-2753	276	3	can	can	AUX
admet-2753	276	4	be	be	AUX
admet-2753	276	5	estimated	estimate	VERB
admet-2753	276	6	as	as	ADP
admet-2753	276	7	:	:	PUNCT
admet-2753	276	8	buffer	buffer	VERB
admet-2753	276	9	u	u	PRON
admet-2753	276	10	cd	cd	NOUN
admet-2753	276	11	s	s	PROPN
admet-2753	276	12	f	f	PROPN
admet-2753	276	13	s	s	PART
admet-2753	276	14	=	=	NOUN
admet-2753	276	15	if	if	SCONJ
admet-2753	276	16	sbuffer	sbuffer	VERB
admet-2753	276	17			NUM
admet-2753	276	18	scd	scd	NOUN
admet-2753	276	19	,	,	PUNCT
admet-2753	276	20	otherwise	otherwise	ADV
admet-2753	276	21	fu	fu	NOUN
admet-2753	276	22	=	=	SYM
admet-2753	276	23	1	1	NUM
admet-2753	276	24	(	(	PUNCT
admet-2753	276	25	4	4	NUM
admet-2753	276	26	)	)	PUNCT
admet-2753	276	27	where	where	SCONJ
admet-2753	276	28	scd	scd	PROPN
admet-2753	276	29	is	be	AUX
admet-2753	276	30	the	the	DET
admet-2753	276	31	solubility	solubility	NOUN
admet-2753	276	32	in	in	ADP
admet-2753	276	33	cd	cd	PROPN
admet-2753	276	34	-	-	PUNCT
admet-2753	276	35	containing	contain	VERB
admet-2753	276	36	media	medium	NOUN
admet-2753	276	37	and	and	CCONJ
admet-2753	276	38	sbuffer	sbuffer	NOUN
admet-2753	276	39	is	be	AUX
admet-2753	276	40	the	the	DET
admet-2753	276	41	solubility	solubility	NOUN
admet-2753	276	42	in	in	ADP
admet-2753	276	43	the	the	DET
admet-2753	276	44	corresponding	corresponding	ADJ
admet-2753	276	45	buffer	buffer	NOUN
admet-2753	276	46	without	without	ADP
admet-2753	276	47	cd	cd	PROPN
admet-2753	276	48	.	.	PUNCT
admet-2753	277	1	based	base	VERB
admet-2753	277	2	on	on	ADP
admet-2753	277	3	equation	equation	NOUN
admet-2753	277	4	(	(	PUNCT
admet-2753	277	5	18	18	NUM
admet-2753	277	6	)	)	PUNCT
admet-2753	277	7	,	,	PUNCT
admet-2753	277	8	equations	equation	NOUN
admet-2753	277	9	(	(	PUNCT
admet-2753	277	10	12	12	NUM
admet-2753	277	11	)	)	PUNCT
admet-2753	277	12	and	and	CCONJ
admet-2753	277	13	(	(	PUNCT
admet-2753	277	14	4	4	NUM
admet-2753	277	15	)	)	PUNCT
admet-2753	277	16	,	,	PUNCT
admet-2753	277	17	flux	flux	PROPN
admet-2753	277	18	can	can	AUX
admet-2753	277	19	be	be	AUX
admet-2753	277	20	expressed	express	VERB
admet-2753	277	21	as	as	SCONJ
admet-2753	277	22	shown	show	VERB
admet-2753	277	23	in	in	ADP
admet-2753	277	24	equation	equation	NOUN
admet-2753	277	25	(	(	PUNCT
admet-2753	277	26	19	19	NUM
admet-2753	277	27	):	):	PUNCT
admet-2753	277	28	buffer	buffer	NOUN
admet-2753	277	29	buffer	buffer	NOUN
admet-2753	277	30	uwl	uwl	PROPN
admet-2753	277	31	,	,	PUNCT
admet-2753	277	32	mono	mono	PROPN
admet-2753	277	33	uwl	uwl	PROPN
admet-2753	277	34	uwl	uwl	PROPN
admet-2753	277	35	,	,	PUNCT
admet-2753	277	36	cd	cd	PROPN
admet-2753	277	37	uwl	uwl	PROPN
admet-2753	277	38	uwl	uwl	PROPN
admet-2753	277	39	,	,	PUNCT
admet-2753	277	40	cd	cd	PROPN
admet-2753	277	41	uwl	uwl	PROPN
admet-2753	277	42	,	,	PUNCT
admet-2753	277	43	cd	cd	PROPN
admet-2753	277	44	d	d	PROPN
admet-2753	277	45	a	a	PROPN
admet-2753	277	46	d	d	X
admet-2753	277	47	a	a	PROPN
admet-2753	277	48	*	*	SYM
admet-2753	277	49	1	1	NUM
admet-2753	277	50	*	*	PUNCT
admet-2753	277	51	           	           	SPACE
admet-2753	278	1	*	*	PUNCT
admet-2753	278	2	*	*	PUNCT
admet-2753	278	3	s	s	X
admet-2753	278	4	s	s	X
admet-2753	278	5	d	d	X
admet-2753	278	6	c	c	PROPN
admet-2753	278	7	d	d	X
admet-2753	278	8	c	c	NOUN
admet-2753	278	9	s	s	X
admet-2753	278	10	s	s	X
admet-2753	278	11	c	c	NOUN
admet-2753	278	12	c	c	NOUN
admet-2753	278	13	j	j	PROPN
admet-2753	278	14	h	h	NOUN
admet-2753	279	1	c	c	NOUN
admet-2753	279	2	c	c	PROPN
admet-2753	279	3			NOUN
admet-2753	279	4			NOUN
admet-2753	279	5	+	+	CCONJ
admet-2753	279	6	−	−	PROPN
admet-2753	279	7			NOUN
admet-2753	279	8			PROPN
admet-2753	279	9			NOUN
admet-2753	279	10			VERB
admet-2753	279	11	=	=	PROPN
admet-2753	279	12	−	−	PROPN
admet-2753	279	13			PROPN
admet-2753	279	14			PROPN
admet-2753	279	15			NOUN
admet-2753	279	16	(	(	PUNCT
admet-2753	279	17	19	19	NUM
admet-2753	279	18	)	)	PUNCT
admet-2753	279	19	considering	consider	VERB
admet-2753	279	20	that	that	SCONJ
admet-2753	279	21	c*uwl=	c*uwl=	NOUN
admet-2753	279	22	suwl	suwl	PROPN
admet-2753	279	23	,	,	PUNCT
admet-2753	279	24	cd	cd	PROPN
admet-2753	279	25	flux	flux	NOUN
admet-2753	279	26	can	can	AUX
admet-2753	279	27	be	be	AUX
admet-2753	279	28	expressed	express	VERB
admet-2753	279	29	as	as	ADP
admet-2753	279	30	shown	show	VERB
admet-2753	279	31	in	in	ADP
admet-2753	279	32	equation	equation	NOUN
admet-2753	279	33	(	(	PUNCT
admet-2753	279	34	20	20	NUM
admet-2753	279	35	)	)	PUNCT
admet-2753	279	36	:	:	PUNCT
admet-2753	279	37	(	(	PUNCT
admet-2753	279	38	)	)	PUNCT
admet-2753	279	39	buffer	buffer	NOUN
admet-2753	279	40	uwl	uwl	PROPN
admet-2753	279	41	,	,	PUNCT
admet-2753	279	42	mono	mono	PROPN
admet-2753	279	43	uwl	uwl	AUX
admet-2753	279	44	buffer	buffer	VERB
admet-2753	279	45	uwl	uwl	PROPN
admet-2753	279	46	,	,	PUNCT
admet-2753	279	47	cd	cd	PROPN
admet-2753	279	48	uwl	uwl	PROPN
admet-2753	279	49	,	,	PUNCT
admet-2753	279	50	eff	eff	PROPN
admet-2753	279	51	uwld	uwld	VERB
admet-2753	279	52	a	a	DET
admet-2753	279	53	d	d	NOUN
admet-2753	279	54	a	a	PROPN
admet-2753	279	55	d	d	PROPN
admet-2753	279	56	a	a	DET
admet-2753	279	57	uwl	uwl	NOUN
admet-2753	279	58	,	,	PUNCT
admet-2753	279	59	eff	eff	PROPN
admet-2753	279	60	d	d	PROPN
admet-2753	279	61	a	a	PROPN
admet-2753	279	62	*	*	PUNCT
admet-2753	280	1	*	*	PUNCT
admet-2753	280	2	  	  	SPACE
admet-2753	280	3	*	*	PUNCT
admet-2753	281	1	*	*	PUNCT
admet-2753	281	2	*	*	PUNCT
admet-2753	281	3	*	*	PUNCT
admet-2753	281	4	s	s	X
admet-2753	281	5	d	d	X
admet-2753	281	6	c	c	NOUN
admet-2753	281	7	s	s	PROPN
admet-2753	281	8	d	d	X
admet-2753	281	9	d	d	NOUN
admet-2753	281	10	cc	cc	X
admet-2753	281	11	c	c	PROPN
admet-2753	281	12	c	c	PROPN
admet-2753	281	13	c	c	PROPN
admet-2753	281	14	j	j	PROPN
admet-2753	281	15	h	h	NOUN
admet-2753	282	1	c	c	NOUN
admet-2753	282	2	c	c	NOUN
admet-2753	283	1	h	h	NOUN
admet-2753	283	2	c	c	NOUN
admet-2753	283	3	c	c	NOUN
admet-2753	284	1	+	+	CCONJ
admet-2753	284	2			NOUN
admet-2753	284	3			NOUN
admet-2753	284	4			NOUN
admet-2753	284	5			NOUN
admet-2753	284	6	=	=	PUNCT
admet-2753	285	1	−	−	PROPN
admet-2753	285	2	=	=	SYM
admet-2753	286	1	−	−	PROPN
admet-2753	286	2			PROPN
admet-2753	287	1			PROPN
admet-2753	287	2			PROPN
admet-2753	288	1			ADJ
admet-2753	288	2			PROPN
admet-2753	288	3			PROPN
admet-2753	288	4			NOUN
admet-2753	288	5	=	=	SYM
admet-2753	288	6	(	(	PUNCT
admet-2753	288	7	20	20	NUM
admet-2753	288	8	)	)	PUNCT
admet-2753	289	1	where	where	SCONJ
admet-2753	289	2	duwl	duwl	NOUN
admet-2753	289	3	,	,	PUNCT
admet-2753	289	4	eff	eff	PROPN
admet-2753	289	5	is	be	AUX
admet-2753	289	6	the	the	DET
admet-2753	289	7	effective	effective	ADJ
admet-2753	289	8	diffusion	diffusion	NOUN
admet-2753	289	9	coefficient	coefficient	NOUN
admet-2753	289	10	through	through	ADP
admet-2753	289	11	the	the	DET
admet-2753	289	12	uwl	uwl	NOUN
admet-2753	289	13	and	and	CCONJ
admet-2753	289	14	huwl	huwl	NOUN
admet-2753	289	15	,	,	PUNCT
admet-2753	289	16	eff	eff	PROPN
admet-2753	289	17	is	be	AUX
admet-2753	289	18	the	the	DET
admet-2753	289	19	effective	effective	ADJ
admet-2753	289	20	thickness	thickness	NOUN
admet-2753	289	21	of	of	ADP
admet-2753	289	22	the	the	DET
admet-2753	289	23	uwl	uwl	NOUN
admet-2753	289	24	in	in	ADP
admet-2753	289	25	the	the	DET
admet-2753	289	26	presence	presence	NOUN
admet-2753	289	27	of	of	ADP
admet-2753	289	28	hp	hp	PROPN
admet-2753	289	29	-	-	PUNCT
admet-2753	289	30	β	β	NOUN
admet-2753	289	31	-	-	NOUN
admet-2753	289	32	cd	cd	NOUN
admet-2753	289	33	.	.	PUNCT
admet-2753	290	1	from	from	ADP
admet-2753	290	2	equation	equation	NOUN
admet-2753	290	3	(	(	PUNCT
admet-2753	290	4	20	20	NUM
admet-2753	290	5	)	)	PUNCT
admet-2753	290	6	it	it	PRON
admet-2753	290	7	can	can	AUX
admet-2753	290	8	be	be	AUX
admet-2753	290	9	concluded	conclude	VERB
admet-2753	290	10	that	that	SCONJ
admet-2753	290	11	the	the	DET
admet-2753	290	12	driving	drive	VERB
admet-2753	290	13	force	force	NOUN
admet-2753	290	14	of	of	ADP
admet-2753	290	15	membrane	membrane	NOUN
admet-2753	290	16	transport	transport	NOUN
admet-2753	290	17	in	in	ADP
admet-2753	290	18	case	case	NOUN
admet-2753	290	19	of	of	ADP
admet-2753	290	20	uwl	uwl	X
admet-2753	290	21	limited	limit	VERB
admet-2753	290	22	transport	transport	NOUN
admet-2753	290	23	condition	condition	NOUN
admet-2753	290	24	is	be	AUX
admet-2753	290	25	the	the	DET
admet-2753	290	26	difference	difference	NOUN
admet-2753	290	27	between	between	ADP
admet-2753	290	28	the	the	DET
admet-2753	290	29	supersaturation	supersaturation	NOUN
admet-2753	290	30	ratio	ratio	NOUN
admet-2753	290	31	(	(	PUNCT
admet-2753	290	32	ssr	ssr	PROPN
admet-2753	290	33	,	,	PUNCT
admet-2753	290	34	defined	define	VERB
admet-2753	290	35	as	as	ADP
admet-2753	290	36	the	the	DET
admet-2753	290	37	ratio	ratio	NOUN
admet-2753	290	38	of	of	ADP
admet-2753	290	39	the	the	DET
admet-2753	290	40	drug	drug	NOUN
admet-2753	290	41	concentration	concentration	NOUN
admet-2753	290	42	present	present	ADJ
admet-2753	290	43	in	in	ADP
admet-2753	290	44	solution	solution	NOUN
admet-2753	290	45	to	to	ADP
admet-2753	290	46	its	its	PRON
admet-2753	290	47	thermodynamic	thermodynamic	ADJ
admet-2753	290	48	solubility	solubility	NOUN
admet-2753	290	49	measured	measure	VERB
admet-2753	290	50	in	in	ADP
admet-2753	290	51	exactly	exactly	ADV
admet-2753	290	52	the	the	DET
admet-2753	290	53	same	same	ADJ
admet-2753	290	54	media	medium	NOUN
admet-2753	290	55	)	)	PUNCT
admet-2753	290	56	in	in	ADP
admet-2753	290	57	the	the	DET
admet-2753	290	58	donor	donor	NOUN
admet-2753	290	59	and	and	CCONJ
admet-2753	290	60	acceptor	acceptor	NOUN
admet-2753	290	61	compartment	compartment	NOUN
admet-2753	290	62	.	.	PUNCT
admet-2753	291	1	this	this	DET
admet-2753	291	2	difference	difference	NOUN
admet-2753	291	3	is	be	AUX
admet-2753	291	4	directly	directly	ADV
admet-2753	291	5	proportional	proportional	ADJ
admet-2753	291	6	to	to	ADP
admet-2753	291	7	the	the	DET
admet-2753	291	8	flux	flux	NOUN
admet-2753	291	9	,	,	PUNCT
admet-2753	291	10	and	and	CCONJ
admet-2753	291	11	the	the	DET
admet-2753	291	12	coefficient	coefficient	NOUN
admet-2753	291	13	of	of	ADP
admet-2753	291	14	proportionality	proportionality	NOUN
admet-2753	291	15	(	(	PUNCT
admet-2753	291	16	buwl	buwl	NOUN
admet-2753	291	17	)	)	PUNCT
admet-2753	291	18	is	be	AUX
admet-2753	291	19	(	(	PUNCT
admet-2753	291	20	duwl	duwl	PROPN
admet-2753	291	21	,	,	PUNCT
admet-2753	291	22	eff	eff	PROPN
admet-2753	291	23	c*uwl	c*uwl	PROPN
admet-2753	291	24	)	)	PUNCT
admet-2753	291	25	/	/	SYM
admet-2753	291	26	huwl	huwl	NOUN
admet-2753	291	27	,	,	PUNCT
admet-2753	291	28	eff	eff	PROPN
admet-2753	291	29	.	.	PROPN
admet-2753	291	30	mathematical	mathematical	ADJ
admet-2753	291	31	description	description	NOUN
admet-2753	291	32	of	of	ADP
admet-2753	291	33	membrane	membrane	NOUN
admet-2753	291	34	transport	transport	NOUN
admet-2753	291	35	in	in	ADP
admet-2753	291	36	membrane	membrane	ADJ
admet-2753	291	37	membrane	membrane	NOUN
admet-2753	291	38	-	-	PUNCT
admet-2753	291	39	limited	limit	VERB
admet-2753	291	40	case	case	NOUN
admet-2753	291	41	a	a	DET
admet-2753	291	42	concentration	concentration	NOUN
admet-2753	291	43	-	-	PUNCT
admet-2753	291	44	based	base	VERB
admet-2753	291	45	mathematical	mathematical	ADJ
admet-2753	291	46	description	description	NOUN
admet-2753	291	47	was	be	AUX
admet-2753	291	48	previously	previously	ADV
admet-2753	291	49	published	publish	VERB
admet-2753	291	50	for	for	ADP
admet-2753	291	51	membrane	membrane	NOUN
admet-2753	291	52	membranelimited	membranelimite	VERB
admet-2753	291	53	case	case	NOUN
admet-2753	291	54	in	in	ADP
admet-2753	291	55	the	the	DET
admet-2753	291	56	case	case	NOUN
admet-2753	291	57	of	of	ADP
admet-2753	291	58	lipophilic	lipophilic	NOUN
admet-2753	291	59	and	and	CCONJ
admet-2753	291	60	also	also	ADV
admet-2753	291	61	size	size	NOUN
admet-2753	291	62	-	-	PUNCT
admet-2753	291	63	exclusion	exclusion	NOUN
admet-2753	291	64	membranes	membrane	NOUN
admet-2753	291	65	[	[	X
admet-2753	291	66	22,62	22,62	NUM
admet-2753	291	67	]	]	X
admet-2753	291	68	.	.	PUNCT
admet-2753	292	1	the	the	DET
admet-2753	292	2	main	main	ADJ
admet-2753	292	3	assumption	assumption	NOUN
admet-2753	292	4	of	of	ADP
admet-2753	292	5	this	this	DET
admet-2753	292	6	model	model	NOUN
admet-2753	292	7	is	be	AUX
admet-2753	292	8	that	that	SCONJ
admet-2753	292	9	the	the	DET
admet-2753	292	10	solubilizing	solubilize	VERB
admet-2753	292	11	agent	agent	NOUN
admet-2753	292	12	can	can	AUX
admet-2753	292	13	not	not	PART
admet-2753	292	14	permeate	permeate	VERB
admet-2753	292	15	the	the	DET
admet-2753	292	16	membrane	membrane	NOUN
admet-2753	292	17	;	;	PUNCT
admet-2753	292	18	only	only	ADV
admet-2753	292	19	the	the	DET
admet-2753	292	20	free	free	ADJ
admet-2753	292	21	drug	drug	NOUN
admet-2753	292	22	is	be	AUX
admet-2753	292	23	able	able	ADJ
admet-2753	292	24	to	to	PART
admet-2753	292	25	pass	pass	VERB
admet-2753	292	26	through	through	ADP
admet-2753	292	27	,	,	PUNCT
admet-2753	292	28	equation	equation	NOUN
admet-2753	292	29	(	(	PUNCT
admet-2753	292	30	21	21	NUM
admet-2753	292	31	)	)	PUNCT
admet-2753	292	32	.	.	PUNCT
admet-2753	293	1	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	293	2	p.	p.	PROPN
admet-2753	293	3	tőzsér	tőzsér	PROPN
admet-2753	293	4	et	et	PROPN
admet-2753	293	5	al	al	PROPN
admet-2753	293	6	.	.	PROPN
admet-2753	293	7	admet	admet	PROPN
admet-2753	293	8	&	&	CCONJ
admet-2753	293	9	dmpk	dmpk	PROPN
admet-2753	293	10	13(4	13(4	NUM
admet-2753	293	11	)	)	PUNCT
admet-2753	293	12	(	(	PUNCT
admet-2753	293	13	2025	2025	NUM
admet-2753	293	14	)	)	PUNCT
admet-2753	293	15	2753	2753	NUM
admet-2753	293	16	16	16	NUM
admet-2753	293	17	m	m	NOUN
admet-2753	293	18	m	m	VERB
admet-2753	293	19	d	d	NOUN
admet-2753	293	20	a	a	X
admet-2753	293	21	d	d	NOUN
admet-2753	293	22	a	a	DET
admet-2753	293	23	m	m	PROPN
admet-2753	293	24	*	*	NOUN
admet-2753	293	25	m	m	PROPN
admet-2753	293	26	d	d	NOUN
admet-2753	293	27	a	a	X
admet-2753	293	28	d	d	NOUN
admet-2753	293	29	a	a	X
admet-2753	293	30	*	*	PUNCT
admet-2753	294	1	*	*	PUNCT
admet-2753	295	1	*	*	PUNCT
admet-2753	295	2	*	*	PUNCT
admet-2753	296	1	d	d	PUNCT
admet-2753	296	2	c	c	NOUN
admet-2753	296	3	c	c	NOUN
admet-2753	296	4	c	c	NOUN
admet-2753	296	5	c	c	NOUN
admet-2753	296	6	c	c	PROPN
admet-2753	296	7	j	j	PROPN
admet-2753	297	1	b	b	PROPN
admet-2753	297	2	h	h	NOUN
admet-2753	298	1	c	c	NOUN
admet-2753	298	2	c	c	NOUN
admet-2753	298	3	c	c	NOUN
admet-2753	298	4	c	c	PROPN
admet-2753	298	5			NOUN
admet-2753	298	6			NOUN
admet-2753	298	7			NOUN
admet-2753	298	8			NOUN
admet-2753	298	9	=	=	PUNCT
admet-2753	299	1	−	−	PROPN
admet-2753	299	2	=	=	SYM
admet-2753	300	1	−	−	PROPN
admet-2753	300	2			PROPN
admet-2753	301	1			PROPN
admet-2753	301	2			PROPN
admet-2753	302	1			ADJ
admet-2753	302	2			PROPN
admet-2753	302	3			PROPN
admet-2753	302	4			NOUN
admet-2753	302	5	(	(	PUNCT
admet-2753	302	6	21	21	NUM
admet-2753	302	7	)	)	PUNCT
admet-2753	302	8	where	where	SCONJ
admet-2753	302	9	bm	bm	PROPN
admet-2753	302	10	is	be	AUX
admet-2753	302	11	the	the	DET
admet-2753	302	12	coefficient	coefficient	NOUN
admet-2753	302	13	of	of	ADP
admet-2753	302	14	proportionality	proportionality	NOUN
admet-2753	302	15	,	,	PUNCT
admet-2753	302	16	dm	dm	PROPN
admet-2753	302	17	is	be	AUX
admet-2753	302	18	the	the	DET
admet-2753	302	19	diffusion	diffusion	NOUN
admet-2753	302	20	coefficient	coefficient	NOUN
admet-2753	302	21	through	through	ADP
admet-2753	302	22	the	the	DET
admet-2753	302	23	membrane	membrane	NOUN
admet-2753	302	24	,	,	PUNCT
admet-2753	302	25	cm	cm	PROPN
admet-2753	302	26	is	be	AUX
admet-2753	302	27	the	the	DET
admet-2753	302	28	concentration	concentration	NOUN
admet-2753	302	29	of	of	ADP
admet-2753	302	30	the	the	DET
admet-2753	302	31	drug	drug	NOUN
admet-2753	302	32	in	in	ADP
admet-2753	302	33	the	the	DET
admet-2753	302	34	membrane	membrane	NOUN
admet-2753	302	35	and	and	CCONJ
admet-2753	302	36	*	*	NOUN
admet-2753	302	37	is	be	AUX
admet-2753	302	38	the	the	DET
admet-2753	302	39	property	property	NOUN
admet-2753	302	40	at	at	ADP
admet-2753	302	41	saturation	saturation	NOUN
admet-2753	302	42	,	,	PUNCT
admet-2753	302	43	hm	hm	INTJ
admet-2753	302	44	is	be	AUX
admet-2753	302	45	the	the	DET
admet-2753	302	46	membrane	membrane	NOUN
admet-2753	302	47	thickness	thickness	NOUN
admet-2753	302	48	.	.	PUNCT
admet-2753	303	1	general	general	ADJ
admet-2753	303	2	mathematical	mathematical	ADJ
admet-2753	303	3	description	description	NOUN
admet-2753	303	4	of	of	ADP
admet-2753	303	5	membrane	membrane	NOUN
admet-2753	303	6	transport	transport	NOUN
admet-2753	303	7	based	base	VERB
admet-2753	303	8	on	on	ADP
admet-2753	303	9	the	the	DET
admet-2753	303	10	membrane	membrane	NOUN
admet-2753	303	11	and	and	CCONJ
admet-2753	303	12	uwl	uwl	ADV
admet-2753	303	13	limited	limited	ADJ
admet-2753	303	14	cases	case	NOUN
admet-2753	303	15	,	,	PUNCT
admet-2753	303	16	a	a	DET
admet-2753	303	17	general	general	ADJ
admet-2753	303	18	model	model	NOUN
admet-2753	303	19	can	can	AUX
admet-2753	303	20	be	be	AUX
admet-2753	303	21	described	describe	VERB
admet-2753	303	22	,	,	PUNCT
admet-2753	303	23	where	where	SCONJ
admet-2753	303	24	both	both	CCONJ
admet-2753	303	25	the	the	DET
admet-2753	303	26	uwl	uwl	NOUN
admet-2753	303	27	and	and	CCONJ
admet-2753	303	28	membrane	membrane	NOUN
admet-2753	303	29	permeation	permeation	NOUN
admet-2753	303	30	are	be	AUX
admet-2753	303	31	considered	consider	VERB
admet-2753	303	32	as	as	ADP
admet-2753	303	33	consecutive	consecutive	ADJ
admet-2753	303	34	processes	process	NOUN
admet-2753	303	35	.	.	PUNCT
admet-2753	304	1	the	the	DET
admet-2753	304	2	main	main	ADJ
admet-2753	304	3	assumption	assumption	NOUN
admet-2753	304	4	of	of	ADP
admet-2753	304	5	this	this	DET
admet-2753	304	6	model	model	NOUN
admet-2753	304	7	is	be	AUX
admet-2753	304	8	that	that	SCONJ
admet-2753	304	9	the	the	DET
admet-2753	304	10	complexing	complexe	VERB
admet-2753	304	11	agent	agent	NOUN
admet-2753	304	12	and	and	CCONJ
admet-2753	304	13	the	the	DET
admet-2753	304	14	drug	drug	NOUN
admet-2753	304	15	-	-	PUNCT
admet-2753	304	16	cd	cd	NOUN
admet-2753	304	17	complex	complex	NOUN
admet-2753	304	18	can	can	AUX
admet-2753	304	19	not	not	PART
admet-2753	304	20	permeate	permeate	VERB
admet-2753	304	21	the	the	DET
admet-2753	304	22	membrane	membrane	NOUN
admet-2753	304	23	.	.	PUNCT
admet-2753	305	1	similarly	similarly	ADV
admet-2753	305	2	to	to	ADP
admet-2753	305	3	permeability	permeability	NOUN
admet-2753	305	4	values	value	NOUN
admet-2753	305	5	(	(	PUNCT
admet-2753	305	6	equation	equation	NOUN
admet-2753	305	7	(	(	PUNCT
admet-2753	305	8	2	2	NUM
admet-2753	305	9	)	)	PUNCT
admet-2753	305	10	)	)	PUNCT
admet-2753	305	11	,	,	PUNCT
admet-2753	305	12	a	a	DET
admet-2753	305	13	reciprocal	reciprocal	ADJ
admet-2753	305	14	relation	relation	NOUN
admet-2753	305	15	can	can	AUX
admet-2753	305	16	be	be	AUX
admet-2753	305	17	made	make	VERB
admet-2753	305	18	between	between	ADP
admet-2753	305	19	the	the	DET
admet-2753	305	20	effective	effective	ADJ
admet-2753	305	21	b	b	NOUN
admet-2753	305	22	factor	factor	NOUN
admet-2753	305	23	and	and	CCONJ
admet-2753	305	24	the	the	DET
admet-2753	305	25	b	b	PROPN
admet-2753	305	26	factor	factor	NOUN
admet-2753	305	27	for	for	ADP
admet-2753	305	28	the	the	DET
admet-2753	305	29	uwl	uwl	NOUN
admet-2753	305	30	and	and	CCONJ
admet-2753	305	31	the	the	DET
admet-2753	305	32	membrane	membrane	NOUN
admet-2753	305	33	(	(	PUNCT
admet-2753	305	34	equation	equation	NOUN
admet-2753	305	35	(	(	PUNCT
admet-2753	305	36	22	22	NUM
admet-2753	305	37	)	)	PUNCT
admet-2753	305	38	)	)	PUNCT
admet-2753	305	39	.	.	PUNCT
admet-2753	306	1	e	e	X
admet-2753	306	2	uwl	uwl	X
admet-2753	306	3	m	m	VERB
admet-2753	306	4	1	1	NUM
admet-2753	306	5	1	1	NUM
admet-2753	306	6	1	1	NUM
admet-2753	306	7	b	b	X
admet-2753	306	8	b	b	PROPN
admet-2753	306	9	b	b	PROPN
admet-2753	306	10	=	=	SYM
admet-2753	306	11	+	+	PROPN
admet-2753	306	12	(	(	PUNCT
admet-2753	306	13	22	22	NUM
admet-2753	306	14	)	)	PUNCT
admet-2753	306	15	therefore	therefore	ADV
admet-2753	306	16	,	,	PUNCT
admet-2753	306	17	flux	flux	PROPN
admet-2753	306	18	can	can	AUX
admet-2753	306	19	be	be	AUX
admet-2753	306	20	expressed	express	VERB
admet-2753	306	21	as	as	ADP
admet-2753	306	22	equation	equation	NOUN
admet-2753	306	23	(	(	PUNCT
admet-2753	306	24	23	23	NUM
admet-2753	306	25	):	):	PUNCT
admet-2753	307	1	d	d	X
admet-2753	307	2	a	a	DET
admet-2753	307	3	e	e	X
admet-2753	307	4	d	d	X
admet-2753	307	5	a	a	PROPN
admet-2753	307	6	*	*	X
admet-2753	307	7	*	*	PUNCT
admet-2753	308	1	c	c	NOUN
admet-2753	308	2	c	c	PROPN
admet-2753	308	3	j	j	PROPN
admet-2753	308	4	b	b	PROPN
admet-2753	308	5	c	c	PROPN
admet-2753	308	6	c	c	PROPN
admet-2753	308	7			NOUN
admet-2753	308	8			NOUN
admet-2753	308	9	=	=	PUNCT
admet-2753	309	1	−	−	PROPN
admet-2753	309	2			PROPN
admet-2753	310	1			PROPN
admet-2753	310	2			NOUN
admet-2753	310	3	(	(	PUNCT
admet-2753	310	4	23	23	NUM
admet-2753	310	5	)	)	PUNCT
admet-2753	310	6	where	where	SCONJ
admet-2753	310	7	be	be	AUX
admet-2753	310	8	is	be	AUX
admet-2753	310	9	the	the	DET
admet-2753	310	10	effective	effective	ADJ
admet-2753	310	11	coefficient	coefficient	NOUN
admet-2753	310	12	of	of	ADP
admet-2753	310	13	proportionality	proportionality	NOUN
admet-2753	310	14	.	.	PUNCT
admet-2753	311	1	the	the	DET
admet-2753	311	2	application	application	NOUN
admet-2753	311	3	of	of	ADP
admet-2753	311	4	the	the	DET
admet-2753	311	5	general	general	ADJ
admet-2753	311	6	mathematical	mathematical	ADJ
admet-2753	311	7	model	model	NOUN
admet-2753	311	8	to	to	ADP
admet-2753	311	9	experimental	experimental	ADJ
admet-2753	311	10	flux	flux	NOUN
admet-2753	311	11	data	datum	NOUN
admet-2753	311	12	for	for	ADP
admet-2753	311	13	lipophilic	lipophilic	ADJ
admet-2753	311	14	membranes	membrane	NOUN
admet-2753	311	15	and	and	CCONJ
admet-2753	311	16	size	size	NOUN
admet-2753	311	17	-	-	PUNCT
admet-2753	311	18	exclusion	exclusion	NOUN
admet-2753	311	19	membranes	membrane	NOUN
admet-2753	311	20	based	base	VERB
admet-2753	311	21	on	on	ADP
admet-2753	311	22	the	the	DET
admet-2753	311	23	results	result	NOUN
admet-2753	311	24	of	of	ADP
admet-2753	311	25	table	table	NOUN
admet-2753	311	26	s2	s2	PROPN
admet-2753	311	27	,	,	PUNCT
admet-2753	311	28	the	the	DET
admet-2753	311	29	limiting	limit	VERB
admet-2753	311	30	step	step	NOUN
admet-2753	311	31	of	of	ADP
admet-2753	311	32	the	the	DET
admet-2753	311	33	transport	transport	NOUN
admet-2753	311	34	for	for	ADP
admet-2753	311	35	the	the	DET
admet-2753	311	36	lipophilic	lipophilic	ADJ
admet-2753	311	37	membrane	membrane	NOUN
admet-2753	311	38	can	can	AUX
admet-2753	311	39	change	change	VERB
admet-2753	311	40	from	from	ADP
admet-2753	311	41	uwl	uwl	PRON
admet-2753	311	42	to	to	ADP
admet-2753	311	43	the	the	DET
admet-2753	311	44	membrane	membrane	NOUN
admet-2753	311	45	when	when	SCONJ
admet-2753	311	46	hp	hp	ADJ
admet-2753	311	47	-	-	PUNCT
admet-2753	311	48	β	β	NOUN
admet-2753	311	49	-	-	NOUN
admet-2753	311	50	cd	cd	NOUN
admet-2753	311	51	is	be	AUX
admet-2753	311	52	present	present	ADJ
admet-2753	311	53	.	.	PUNCT
admet-2753	312	1	this	this	DET
admet-2753	312	2	observation	observation	NOUN
admet-2753	312	3	is	be	AUX
admet-2753	312	4	in	in	ADP
admet-2753	312	5	agreement	agreement	NOUN
admet-2753	312	6	with	with	ADP
admet-2753	312	7	the	the	DET
admet-2753	312	8	previously	previously	ADV
admet-2753	312	9	published	publish	VERB
admet-2753	312	10	observation	observation	NOUN
admet-2753	312	11	from	from	ADP
admet-2753	312	12	dahan	dahan	PROPN
admet-2753	312	13	and	and	CCONJ
admet-2753	312	14	miller	miller	PROPN
admet-2753	313	1	[	[	X
admet-2753	313	2	46	46	NUM
admet-2753	313	3	]	]	PUNCT
admet-2753	313	4	.	.	PUNCT
admet-2753	314	1	therefore	therefore	ADV
admet-2753	314	2	,	,	PUNCT
admet-2753	314	3	the	the	DET
admet-2753	314	4	general	general	ADJ
admet-2753	314	5	model	model	NOUN
admet-2753	314	6	(	(	PUNCT
admet-2753	314	7	equation	equation	NOUN
admet-2753	314	8	(	(	PUNCT
admet-2753	314	9	23	23	NUM
admet-2753	314	10	)	)	PUNCT
admet-2753	314	11	)	)	PUNCT
admet-2753	314	12	was	be	AUX
admet-2753	314	13	applied	apply	VERB
admet-2753	314	14	to	to	ADP
admet-2753	314	15	the	the	DET
admet-2753	314	16	flux	flux	NOUN
admet-2753	314	17	dataset	dataset	NOUN
admet-2753	314	18	of	of	ADP
admet-2753	314	19	lipophilic	lipophilic	ADJ
admet-2753	314	20	membranes	membrane	NOUN
admet-2753	314	21	.	.	PUNCT
admet-2753	315	1	the	the	DET
admet-2753	315	2	primary	primary	ADJ
admet-2753	315	3	assumption	assumption	NOUN
admet-2753	315	4	of	of	ADP
admet-2753	315	5	this	this	DET
admet-2753	315	6	model	model	NOUN
admet-2753	315	7	is	be	AUX
admet-2753	315	8	that	that	SCONJ
admet-2753	315	9	the	the	DET
admet-2753	315	10	complexing	complexe	VERB
admet-2753	315	11	agent	agent	NOUN
admet-2753	315	12	and	and	CCONJ
admet-2753	315	13	the	the	DET
admet-2753	315	14	drug	drug	NOUN
admet-2753	315	15	-	-	PUNCT
admet-2753	315	16	cd	cd	NOUN
admet-2753	315	17	complex	complex	NOUN
admet-2753	315	18	can	can	AUX
admet-2753	315	19	not	not	PART
admet-2753	315	20	permeate	permeate	VERB
admet-2753	315	21	the	the	DET
admet-2753	315	22	membrane	membrane	NOUN
admet-2753	315	23	,	,	PUNCT
admet-2753	315	24	which	which	PRON
admet-2753	315	25	has	have	AUX
admet-2753	315	26	been	be	AUX
admet-2753	315	27	proven	prove	VERB
admet-2753	315	28	to	to	PART
admet-2753	315	29	be	be	AUX
admet-2753	315	30	the	the	DET
admet-2753	315	31	case	case	NOUN
admet-2753	315	32	for	for	ADP
admet-2753	315	33	a	a	DET
admet-2753	315	34	lipophilic	lipophilic	ADJ
admet-2753	315	35	membrane	membrane	NOUN
admet-2753	315	36	(	(	PUNCT
admet-2753	315	37	see	see	VERB
admet-2753	315	38	figure	figure	NOUN
admet-2753	315	39	5	5	NUM
admet-2753	315	40	)	)	PUNCT
admet-2753	315	41	.	.	PUNCT
admet-2753	316	1	figure	figure	NOUN
admet-2753	316	2	9	9	NUM
admet-2753	316	3	shows	show	VERB
admet-2753	316	4	the	the	DET
admet-2753	316	5	flux	flux	NOUN
admet-2753	316	6	plotted	plot	VERB
admet-2753	316	7	as	as	ADP
admet-2753	316	8	a	a	DET
admet-2753	316	9	function	function	NOUN
admet-2753	316	10	of	of	ADP
admet-2753	316	11	the	the	DET
admet-2753	316	12	difference	difference	NOUN
admet-2753	316	13	in	in	ADP
admet-2753	316	14	ssr	ssr	PROPN
admet-2753	316	15	.	.	PUNCT
admet-2753	317	1	the	the	DET
admet-2753	317	2	slopes	slope	NOUN
admet-2753	317	3	of	of	ADP
admet-2753	317	4	the	the	DET
admet-2753	317	5	lines	line	NOUN
admet-2753	317	6	equal	equal	VERB
admet-2753	317	7	the	the	DET
admet-2753	317	8	coefficient	coefficient	NOUN
admet-2753	317	9	of	of	ADP
admet-2753	317	10	proportionality	proportionality	NOUN
admet-2753	317	11	.	.	PUNCT
admet-2753	318	1	homogeneity	homogeneity	NOUN
admet-2753	318	2	of	of	ADP
admet-2753	318	3	slopes	slope	NOUN
admet-2753	318	4	tests	test	NOUN
admet-2753	318	5	with	with	ADP
admet-2753	318	6	the	the	DET
admet-2753	318	7	sample	sample	NOUN
admet-2753	318	8	size	size	NOUN
admet-2753	318	9	8	8	NUM
admet-2753	318	10	-	-	SYM
admet-2753	318	11	12	12	NUM
admet-2753	318	12	were	be	AUX
admet-2753	318	13	carried	carry	VERB
admet-2753	318	14	out	out	ADP
admet-2753	318	15	to	to	PART
admet-2753	318	16	see	see	VERB
admet-2753	318	17	if	if	SCONJ
admet-2753	318	18	the	the	DET
admet-2753	318	19	line	line	NOUN
admet-2753	318	20	of	of	ADP
admet-2753	318	21	the	the	DET
admet-2753	318	22	plain	plain	ADJ
admet-2753	318	23	buffer	buffer	NOUN
admet-2753	318	24	(	(	PUNCT
admet-2753	318	25	red	red	ADJ
admet-2753	318	26	)	)	PUNCT
admet-2753	318	27	and	and	CCONJ
admet-2753	318	28	the	the	DET
admet-2753	318	29	hp	hp	PROPN
admet-2753	318	30	-	-	PUNCT
admet-2753	318	31	β	β	NOUN
admet-2753	318	32	-	-	ADJ
admet-2753	318	33	cd	cd	ADJ
admet-2753	318	34	containing	contain	VERB
admet-2753	318	35	buffer	buffer	NOUN
admet-2753	318	36	(	(	PUNCT
admet-2753	318	37	green	green	ADJ
admet-2753	318	38	)	)	PUNCT
admet-2753	318	39	differ	differ	VERB
admet-2753	318	40	(	(	PUNCT
admet-2753	318	41	table	table	NOUN
admet-2753	318	42	6	6	NUM
admet-2753	318	43	)	)	PUNCT
admet-2753	318	44	.	.	PUNCT
admet-2753	319	1	according	accord	VERB
admet-2753	319	2	to	to	ADP
admet-2753	319	3	the	the	DET
admet-2753	319	4	statistical	statistical	ADJ
admet-2753	319	5	analysis	analysis	NOUN
admet-2753	319	6	,	,	PUNCT
admet-2753	319	7	the	the	DET
admet-2753	319	8	null	null	ADJ
admet-2753	319	9	hypothesis	hypothesis	NOUN
admet-2753	319	10	of	of	ADP
admet-2753	319	11	parallel	parallel	ADJ
admet-2753	319	12	lines	line	NOUN
admet-2753	319	13	can	can	AUX
admet-2753	319	14	not	not	PART
admet-2753	319	15	be	be	AUX
admet-2753	319	16	rejected	reject	VERB
admet-2753	319	17	in	in	ADP
admet-2753	319	18	the	the	DET
admet-2753	319	19	case	case	NOUN
admet-2753	319	20	of	of	ADP
admet-2753	319	21	lipophilic	lipophilic	ADJ
admet-2753	319	22	membranes	membrane	NOUN
admet-2753	319	23	for	for	ADP
admet-2753	319	24	both	both	DET
admet-2753	319	25	0	0	NUM
admet-2753	319	26	rpm	rpm	NOUN
admet-2753	319	27	and	and	CCONJ
admet-2753	319	28	250	250	NUM
admet-2753	319	29	rpm	rpm	NOUN
admet-2753	319	30	.	.	PUNCT
admet-2753	320	1	table	table	NOUN
admet-2753	320	2	6	6	NUM
admet-2753	320	3	.	.	PUNCT
admet-2753	320	4	homogeneity	homogeneity	NOUN
admet-2753	320	5	of	of	ADP
admet-2753	320	6	slopes	slope	NOUN
admet-2753	320	7	test	test	NOUN
admet-2753	320	8	results	result	NOUN
admet-2753	320	9	for	for	ADP
admet-2753	320	10	flux	flux	NOUN
admet-2753	320	11	-	-	PUNCT
admet-2753	320	12	ssr	ssr	ADJ
admet-2753	320	13	curves	curve	NOUN
admet-2753	320	14	in	in	ADP
admet-2753	320	15	ph	ph	ADJ
admet-2753	320	16	10	10	NUM
admet-2753	320	17	buffer	buffer	NOUN
admet-2753	320	18	with	with	ADP
admet-2753	320	19	250	250	NUM
admet-2753	320	20	rpm	rpm	ADJ
admet-2753	320	21	stirring	stirring	NOUN
admet-2753	320	22	rate	rate	NOUN
admet-2753	320	23	and	and	CCONJ
admet-2753	320	24	with	with	ADP
admet-2753	320	25	0	0	NUM
admet-2753	320	26	rpm	rpm	ADJ
admet-2753	320	27	stirring	stirring	NOUN
admet-2753	320	28	rate	rate	NOUN
admet-2753	320	29	,	,	PUNCT
admet-2753	320	30	in	in	ADP
admet-2753	320	31	case	case	NOUN
admet-2753	320	32	of	of	ADP
admet-2753	320	33	lipophilic	lipophilic	ADJ
admet-2753	320	34	membrane	membrane	NOUN
admet-2753	320	35	,	,	PUNCT
admet-2753	320	36	6	6	NUM
admet-2753	320	37	and	and	CCONJ
admet-2753	320	38	1	1	NUM
admet-2753	320	39	kda	kda	NOUN
admet-2753	320	40	size	size	NOUN
admet-2753	320	41	-	-	PUNCT
admet-2753	320	42	exclusion	exclusion	NOUN
admet-2753	320	43	membranes	membrane	NOUN
admet-2753	320	44	p	p	NOUN
admet-2753	320	45	-	-	PUNCT
admet-2753	320	46	value	value	NOUN
admet-2753	320	47	for	for	ADP
admet-2753	320	48	250	250	NUM
admet-2753	320	49	rpm	rpm	NOUN
admet-2753	320	50	p	p	NOUN
admet-2753	320	51	-	-	PUNCT
admet-2753	320	52	value	value	NOUN
admet-2753	320	53	for	for	ADP
admet-2753	320	54	0	0	NUM
admet-2753	320	55	rpm	rpm	NOUN
admet-2753	320	56	lipophilic	lipophilic	NOUN
admet-2753	320	57	0.149329	0.149329	NUM
admet-2753	320	58	0.839690	0.839690	NUM
admet-2753	320	59	1	1	NUM
admet-2753	320	60	kda	kda	NOUN
admet-2753	320	61	0.169113	0.169113	NUM
admet-2753	320	62	0.205616	0.205616	NUM
admet-2753	320	63	6	6	NUM
admet-2753	320	64	kda	kda	NOUN
admet-2753	320	65	0.000028	0.000028	NUM
admet-2753	320	66	0.000000	0.000000	NUM
admet-2753	320	67	for	for	ADP
admet-2753	320	68	a	a	DET
admet-2753	320	69	size	size	NOUN
admet-2753	320	70	-	-	PUNCT
admet-2753	320	71	exclusion	exclusion	NOUN
admet-2753	320	72	membrane	membrane	NOUN
admet-2753	320	73	with	with	ADP
admet-2753	320	74	1	1	NUM
admet-2753	320	75	kda	kda	NOUN
admet-2753	320	76	mwco	mwco	NOUN
admet-2753	320	77	,	,	PUNCT
admet-2753	320	78	the	the	DET
admet-2753	320	79	general	general	ADJ
admet-2753	320	80	model	model	NOUN
admet-2753	320	81	was	be	AUX
admet-2753	320	82	also	also	ADV
admet-2753	320	83	applied	apply	VERB
admet-2753	320	84	(	(	PUNCT
admet-2753	320	85	figure	figure	NOUN
admet-2753	320	86	9	9	NUM
admet-2753	320	87	)	)	PUNCT
admet-2753	320	88	;	;	PUNCT
admet-2753	320	89	however	however	ADV
admet-2753	320	90	,	,	PUNCT
admet-2753	320	91	the	the	DET
admet-2753	320	92	assumption	assumption	NOUN
admet-2753	320	93	that	that	SCONJ
admet-2753	320	94	the	the	DET
admet-2753	320	95	complexing	complexe	VERB
admet-2753	320	96	agent	agent	NOUN
admet-2753	320	97	is	be	AUX
admet-2753	320	98	not	not	PART
admet-2753	320	99	crossing	cross	VERB
admet-2753	320	100	the	the	DET
admet-2753	320	101	membrane	membrane	NOUN
admet-2753	320	102	is	be	AUX
admet-2753	320	103	not	not	PART
admet-2753	320	104	true	true	ADJ
admet-2753	320	105	,	,	PUNCT
admet-2753	320	106	since	since	SCONJ
admet-2753	320	107	a	a	DET
admet-2753	320	108	small	small	ADJ
admet-2753	320	109	amount	amount	NOUN
admet-2753	320	110	of	of	ADP
admet-2753	320	111	hp	hp	NOUN
admet-2753	320	112	-	-	PUNCT
admet-2753	320	113	β	β	NOUN
admet-2753	320	114	-	-	NOUN
admet-2753	320	115	cd	cd	PROPN
admet-2753	320	116	was	be	AUX
admet-2753	320	117	observed	observe	VERB
admet-2753	320	118	at	at	ADP
admet-2753	320	119	the	the	DET
admet-2753	320	120	acceptor	acceptor	NOUN
admet-2753	320	121	side	side	NOUN
admet-2753	320	122	(	(	PUNCT
admet-2753	320	123	figure	figure	NOUN
admet-2753	320	124	5	5	NUM
admet-2753	320	125	)	)	PUNCT
admet-2753	320	126	.	.	PUNCT
admet-2753	321	1	according	accord	VERB
admet-2753	321	2	to	to	ADP
admet-2753	321	3	the	the	DET
admet-2753	321	4	results	result	NOUN
admet-2753	321	5	of	of	ADP
admet-2753	321	6	the	the	DET
admet-2753	321	7	homogeneity	homogeneity	NOUN
admet-2753	321	8	of	of	ADP
admet-2753	321	9	slopes	slope	NOUN
admet-2753	321	10	test	test	NOUN
admet-2753	321	11	for	for	ADP
admet-2753	321	12	1	1	NUM
admet-2753	321	13	kda	kda	NOUN
admet-2753	321	14	mwco	mwco	NOUN
admet-2753	321	15	membrane	membrane	NOUN
admet-2753	321	16	(	(	PUNCT
admet-2753	321	17	table	table	NOUN
admet-2753	321	18	6	6	NUM
admet-2753	321	19	)	)	PUNCT
admet-2753	321	20	,	,	PUNCT
admet-2753	321	21	the	the	DET
admet-2753	321	22	null	null	ADJ
admet-2753	321	23	hypothesis	hypothesis	NOUN
admet-2753	321	24	of	of	ADP
admet-2753	321	25	parallel	parallel	ADJ
admet-2753	321	26	lines	line	NOUN
admet-2753	321	27	can	can	AUX
admet-2753	321	28	not	not	PART
admet-2753	321	29	be	be	AUX
admet-2753	321	30	rejected	reject	VERB
admet-2753	321	31	in	in	ADP
admet-2753	321	32	the	the	DET
admet-2753	321	33	case	case	NOUN
admet-2753	321	34	of	of	ADP
admet-2753	321	35	0	0	NUM
admet-2753	321	36	rpm	rpm	NOUN
admet-2753	321	37	and	and	CCONJ
admet-2753	321	38	250	250	NUM
admet-2753	321	39	rpm	rpm	NOUN
admet-2753	321	40	.	.	PUNCT
admet-2753	322	1	admet	admet	PROPN
admet-2753	322	2	&	&	CCONJ
admet-2753	322	3	dmpk	dmpk	PROPN
admet-2753	322	4	13(4	13(4	NUM
admet-2753	322	5	)	)	PUNCT
admet-2753	322	6	(	(	PUNCT
admet-2753	322	7	2025	2025	NUM
admet-2753	322	8	)	)	PUNCT
admet-2753	322	9	2753	2753	NUM
admet-2753	322	10	comparison	comparison	NOUN
admet-2753	322	11	of	of	ADP
admet-2753	322	12	lipophilic	lipophilic	ADJ
admet-2753	322	13	and	and	CCONJ
admet-2753	322	14	size	size	NOUN
admet-2753	322	15	-	-	PUNCT
admet-2753	322	16	exclusion	exclusion	NOUN
admet-2753	322	17	membranes	membrane	NOUN
admet-2753	322	18	doi	doi	NOUN
admet-2753	322	19	:	:	PUNCT
admet-2753	322	20	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	322	21	17	17	NUM
admet-2753	322	22	in	in	ADP
admet-2753	322	23	case	case	NOUN
admet-2753	322	24	of	of	ADP
admet-2753	322	25	size	size	NOUN
admet-2753	322	26	-	-	PUNCT
admet-2753	322	27	exclusion	exclusion	NOUN
admet-2753	322	28	membrane	membrane	NOUN
admet-2753	322	29	with	with	ADP
admet-2753	322	30	6	6	NUM
admet-2753	322	31	kda	kda	NOUN
admet-2753	322	32	mwco	mwco	NOUN
admet-2753	322	33	significant	significant	ADJ
admet-2753	322	34	difference	difference	NOUN
admet-2753	322	35	can	can	AUX
admet-2753	322	36	be	be	AUX
admet-2753	322	37	seen	see	VERB
admet-2753	322	38	in	in	ADP
admet-2753	322	39	the	the	DET
admet-2753	322	40	slopes	slope	NOUN
admet-2753	322	41	(	(	PUNCT
admet-2753	322	42	see	see	VERB
admet-2753	322	43	pvalues	pvalue	NOUN
admet-2753	322	44	in	in	ADP
admet-2753	322	45	table	table	NOUN
admet-2753	322	46	6	6	NUM
admet-2753	322	47	and	and	CCONJ
admet-2753	322	48	also	also	ADV
admet-2753	322	49	additional	additional	ADJ
admet-2753	322	50	statistical	statistical	ADJ
admet-2753	322	51	information	information	NOUN
admet-2753	322	52	on	on	ADP
admet-2753	322	53	homogeneity	homogeneity	NOUN
admet-2753	322	54	of	of	ADP
admet-2753	322	55	slopes	slope	NOUN
admet-2753	322	56	test	test	NOUN
admet-2753	322	57	in	in	ADP
admet-2753	322	58	supplement	supplement	NOUN
admet-2753	322	59	tables	table	NOUN
admet-2753	322	60	s3	s3	PROPN
admet-2753	322	61	to	to	PART
admet-2753	322	62	s14	s14	VERB
admet-2753	322	63	)	)	PUNCT
admet-2753	322	64	therefore	therefore	ADV
admet-2753	322	65	the	the	DET
admet-2753	322	66	null	null	ADJ
admet-2753	322	67	hypothesis	hypothesis	NOUN
admet-2753	322	68	is	be	AUX
admet-2753	322	69	rejected	reject	VERB
admet-2753	322	70	at	at	ADP
admet-2753	322	71	both	both	PRON
admet-2753	322	72	0	0	NUM
admet-2753	322	73	rpm	rpm	NOUN
admet-2753	322	74	and	and	CCONJ
admet-2753	322	75	250	250	NUM
admet-2753	322	76	rpm	rpm	NOUN
admet-2753	322	77	,	,	PUNCT
admet-2753	322	78	showing	show	VERB
admet-2753	322	79	that	that	SCONJ
admet-2753	322	80	the	the	DET
admet-2753	322	81	amount	amount	NOUN
admet-2753	322	82	of	of	ADP
admet-2753	322	83	cd	cd	PROPN
admet-2753	322	84	crossing	cross	VERB
admet-2753	322	85	the	the	DET
admet-2753	322	86	6	6	NUM
admet-2753	322	87	kda	kda	NOUN
admet-2753	322	88	size	size	NOUN
admet-2753	322	89	-	-	PUNCT
admet-2753	322	90	exclusion	exclusion	NOUN
admet-2753	322	91	membrane	membrane	NOUN
admet-2753	322	92	(	(	PUNCT
admet-2753	322	93	figure	figure	NOUN
admet-2753	322	94	5	5	NUM
admet-2753	322	95	)	)	PUNCT
admet-2753	322	96	truly	truly	ADV
admet-2753	322	97	makes	make	VERB
admet-2753	322	98	a	a	DET
admet-2753	322	99	significant	significant	ADJ
admet-2753	322	100	deviance	deviance	NOUN
admet-2753	322	101	from	from	ADP
admet-2753	322	102	the	the	DET
admet-2753	322	103	mathematical	mathematical	ADJ
admet-2753	322	104	model	model	NOUN
admet-2753	322	105	that	that	PRON
admet-2753	322	106	only	only	ADV
admet-2753	322	107	considers	consider	VERB
admet-2753	322	108	the	the	DET
admet-2753	322	109	drug	drug	NOUN
admet-2753	322	110	crossing	cross	VERB
admet-2753	322	111	through	through	ADP
admet-2753	322	112	the	the	DET
admet-2753	322	113	membrane	membrane	NOUN
admet-2753	322	114	.	.	PUNCT
admet-2753	323	1	when	when	SCONJ
admet-2753	323	2	comparing	compare	VERB
admet-2753	323	3	the	the	DET
admet-2753	323	4	applicability	applicability	NOUN
admet-2753	323	5	of	of	ADP
admet-2753	323	6	the	the	DET
admet-2753	323	7	model	model	NOUN
admet-2753	323	8	for	for	ADP
admet-2753	323	9	the	the	DET
admet-2753	323	10	3	3	NUM
admet-2753	323	11	membranes	membrane	NOUN
admet-2753	323	12	,	,	PUNCT
admet-2753	323	13	a	a	DET
admet-2753	323	14	tendency	tendency	NOUN
admet-2753	323	15	can	can	AUX
admet-2753	323	16	be	be	AUX
admet-2753	323	17	observed	observe	VERB
admet-2753	323	18	in	in	ADP
admet-2753	323	19	the	the	DET
admet-2753	323	20	flux	flux	NOUN
admet-2753	323	21	-	-	PUNCT
admet-2753	323	22	ssr	ssr	ADJ
admet-2753	323	23	diagrams	diagram	NOUN
admet-2753	323	24	.	.	PUNCT
admet-2753	324	1	the	the	DET
admet-2753	324	2	results	result	NOUN
admet-2753	324	3	of	of	ADP
admet-2753	324	4	the	the	DET
admet-2753	324	5	lipophilic	lipophilic	ADJ
admet-2753	324	6	membrane	membrane	NOUN
admet-2753	324	7	show	show	NOUN
admet-2753	324	8	almost	almost	ADV
admet-2753	324	9	perfect	perfect	ADJ
admet-2753	324	10	parallel	parallel	ADJ
admet-2753	324	11	lines	line	NOUN
admet-2753	324	12	,	,	PUNCT
admet-2753	324	13	while	while	SCONJ
admet-2753	324	14	in	in	ADP
admet-2753	324	15	the	the	DET
admet-2753	324	16	case	case	NOUN
admet-2753	324	17	of	of	ADP
admet-2753	324	18	the	the	DET
admet-2753	324	19	size	size	NOUN
admet-2753	324	20	-	-	PUNCT
admet-2753	324	21	exclusion	exclusion	NOUN
admet-2753	324	22	membranes	membrane	NOUN
admet-2753	324	23	,	,	PUNCT
admet-2753	324	24	a	a	DET
admet-2753	324	25	slightly	slightly	ADV
admet-2753	324	26	higher	high	ADJ
admet-2753	324	27	slope	slope	NOUN
admet-2753	324	28	is	be	AUX
admet-2753	324	29	produced	produce	VERB
admet-2753	324	30	in	in	ADP
admet-2753	324	31	the	the	DET
admet-2753	324	32	case	case	NOUN
admet-2753	324	33	of	of	ADP
admet-2753	324	34	1	1	NUM
admet-2753	324	35	kda	kda	NOUN
admet-2753	324	36	mwco	mwco	PROPN
admet-2753	324	37	membrane	membrane	NOUN
admet-2753	324	38	,	,	PUNCT
admet-2753	324	39	and	and	CCONJ
admet-2753	324	40	an	an	DET
admet-2753	324	41	even	even	ADV
admet-2753	324	42	higher	high	ADJ
admet-2753	324	43	slope	slope	NOUN
admet-2753	324	44	was	be	AUX
admet-2753	324	45	seen	see	VERB
admet-2753	324	46	in	in	ADP
admet-2753	324	47	the	the	DET
admet-2753	324	48	case	case	NOUN
admet-2753	324	49	of	of	ADP
admet-2753	324	50	the	the	DET
admet-2753	324	51	6	6	NUM
admet-2753	324	52	kda	kda	NOUN
admet-2753	324	53	mwco	mwco	NOUN
admet-2753	324	54	membrane	membrane	NOUN
admet-2753	324	55	in	in	ADP
admet-2753	324	56	the	the	DET
admet-2753	324	57	presence	presence	NOUN
admet-2753	324	58	of	of	ADP
admet-2753	324	59	the	the	DET
admet-2753	324	60	hp	hp	PROPN
admet-2753	324	61	-	-	PUNCT
admet-2753	324	62	β	β	NOUN
admet-2753	324	63	-	-	NOUN
admet-2753	324	64	cd	cd	NOUN
admet-2753	324	65	.	.	PUNCT
admet-2753	325	1	in	in	ADP
admet-2753	325	2	the	the	DET
admet-2753	325	3	case	case	NOUN
admet-2753	325	4	of	of	ADP
admet-2753	325	5	the	the	DET
admet-2753	325	6	6	6	NUM
admet-2753	325	7	kda	kda	NOUN
admet-2753	325	8	membranes	membrane	NOUN
admet-2753	325	9	,	,	PUNCT
admet-2753	325	10	the	the	DET
admet-2753	325	11	transport	transport	NOUN
admet-2753	325	12	of	of	ADP
admet-2753	325	13	cd	cd	PROPN
admet-2753	325	14	through	through	ADP
admet-2753	325	15	the	the	DET
admet-2753	325	16	membrane	membrane	NOUN
admet-2753	325	17	is	be	AUX
admet-2753	325	18	faster	fast	ADJ
admet-2753	325	19	(	(	PUNCT
admet-2753	325	20	see	see	VERB
admet-2753	325	21	figure	figure	NOUN
admet-2753	325	22	5	5	NUM
admet-2753	325	23	)	)	PUNCT
admet-2753	325	24	than	than	ADP
admet-2753	325	25	in	in	ADP
admet-2753	325	26	the	the	DET
admet-2753	325	27	case	case	NOUN
admet-2753	325	28	of	of	ADP
admet-2753	325	29	the	the	DET
admet-2753	325	30	1	1	NUM
admet-2753	325	31	kda	kda	NOUN
admet-2753	325	32	membrane	membrane	NOUN
admet-2753	325	33	;	;	PUNCT
admet-2753	325	34	therefore	therefore	ADV
admet-2753	325	35	,	,	PUNCT
admet-2753	325	36	the	the	DET
admet-2753	325	37	deviation	deviation	NOUN
admet-2753	325	38	from	from	ADP
admet-2753	325	39	the	the	DET
admet-2753	325	40	parallel	parallel	ADJ
admet-2753	325	41	line	line	NOUN
admet-2753	325	42	is	be	AUX
admet-2753	325	43	also	also	ADV
admet-2753	325	44	bigger	big	ADJ
admet-2753	325	45	.	.	PUNCT
admet-2753	326	1	this	this	DET
admet-2753	326	2	observation	observation	NOUN
admet-2753	326	3	implies	imply	VERB
admet-2753	326	4	that	that	SCONJ
admet-2753	326	5	the	the	DET
admet-2753	326	6	deviation	deviation	NOUN
admet-2753	326	7	from	from	ADP
admet-2753	326	8	the	the	DET
admet-2753	326	9	parallel	parallel	ADJ
admet-2753	326	10	lines	line	NOUN
admet-2753	326	11	is	be	AUX
admet-2753	326	12	due	due	ADJ
admet-2753	326	13	to	to	ADP
admet-2753	326	14	the	the	DET
admet-2753	326	15	failure	failure	NOUN
admet-2753	326	16	of	of	ADP
admet-2753	326	17	the	the	DET
admet-2753	326	18	main	main	ADJ
admet-2753	326	19	assumption	assumption	NOUN
admet-2753	326	20	of	of	ADP
admet-2753	326	21	the	the	DET
admet-2753	326	22	model	model	NOUN
admet-2753	326	23	,	,	PUNCT
admet-2753	326	24	namely	namely	ADV
admet-2753	326	25	that	that	SCONJ
admet-2753	326	26	solubilizing	solubilize	VERB
admet-2753	326	27	agent	agent	NOUN
admet-2753	326	28	and	and	CCONJ
admet-2753	326	29	drug	drug	NOUN
admet-2753	326	30	-	-	PUNCT
admet-2753	326	31	cd	cd	NOUN
admet-2753	326	32	complexes	complex	NOUN
admet-2753	326	33	do	do	AUX
admet-2753	326	34	not	not	PART
admet-2753	326	35	go	go	VERB
admet-2753	326	36	through	through	ADP
admet-2753	326	37	the	the	DET
admet-2753	326	38	membrane	membrane	NOUN
admet-2753	326	39	.	.	PUNCT
admet-2753	327	1	therefore	therefore	ADV
admet-2753	327	2	,	,	PUNCT
admet-2753	327	3	the	the	DET
admet-2753	327	4	increase	increase	NOUN
admet-2753	327	5	in	in	ADP
admet-2753	327	6	flux	flux	NOUN
admet-2753	327	7	at	at	ADP
admet-2753	327	8	a	a	DET
admet-2753	327	9	certain	certain	ADJ
admet-2753	327	10	ssr	ssr	ADJ
admet-2753	327	11	value	value	NOUN
admet-2753	327	12	due	due	ADP
admet-2753	327	13	to	to	ADP
admet-2753	327	14	the	the	DET
admet-2753	327	15	addition	addition	NOUN
admet-2753	327	16	of	of	ADP
admet-2753	327	17	hp	hp	NOUN
admet-2753	327	18	-	-	PUNCT
admet-2753	327	19	β	β	NOUN
admet-2753	327	20	-	-	NOUN
admet-2753	327	21	cd	cd	NOUN
admet-2753	327	22	in	in	ADP
admet-2753	327	23	the	the	DET
admet-2753	327	24	donor	donor	NOUN
admet-2753	327	25	compartment	compartment	NOUN
admet-2753	327	26	can	can	AUX
admet-2753	327	27	be	be	AUX
admet-2753	327	28	attributed	attribute	VERB
admet-2753	327	29	to	to	ADP
admet-2753	327	30	the	the	DET
admet-2753	327	31	flux	flux	NOUN
admet-2753	327	32	generated	generate	VERB
admet-2753	327	33	from	from	ADP
admet-2753	327	34	the	the	DET
admet-2753	327	35	drug	drug	NOUN
admet-2753	327	36	-	-	PUNCT
admet-2753	327	37	cd	cd	NOUN
admet-2753	327	38	complex	complex	NOUN
admet-2753	327	39	in	in	ADP
admet-2753	327	40	the	the	DET
admet-2753	327	41	case	case	NOUN
admet-2753	327	42	of	of	ADP
admet-2753	327	43	size	size	NOUN
admet-2753	327	44	-	-	PUNCT
admet-2753	327	45	exclusion	exclusion	NOUN
admet-2753	327	46	membranes	membrane	NOUN
admet-2753	327	47	.	.	PUNCT
admet-2753	328	1	in	in	ADP
admet-2753	328	2	conclusion	conclusion	NOUN
admet-2753	328	3	,	,	PUNCT
admet-2753	328	4	experimental	experimental	ADJ
admet-2753	328	5	data	datum	NOUN
admet-2753	328	6	supports	support	VERB
admet-2753	328	7	that	that	SCONJ
admet-2753	328	8	in	in	ADP
admet-2753	328	9	case	case	NOUN
admet-2753	328	10	of	of	ADP
admet-2753	328	11	the	the	DET
admet-2753	328	12	lipophilic	lipophilic	NOUN
admet-2753	328	13	and	and	CCONJ
admet-2753	328	14	1	1	NUM
admet-2753	328	15	kda	kda	NOUN
admet-2753	328	16	size	size	NOUN
admet-2753	328	17	-	-	PUNCT
admet-2753	328	18	exclusion	exclusion	NOUN
admet-2753	328	19	membrane	membrane	NOUN
admet-2753	328	20	the	the	DET
admet-2753	328	21	true	true	ADJ
admet-2753	328	22	driving	drive	VERB
admet-2753	328	23	force	force	NOUN
admet-2753	328	24	of	of	ADP
admet-2753	328	25	membrane	membrane	NOUN
admet-2753	328	26	transport	transport	NOUN
admet-2753	328	27	is	be	AUX
admet-2753	328	28	the	the	DET
admet-2753	328	29	difference	difference	NOUN
admet-2753	328	30	is	be	AUX
admet-2753	328	31	ssr	ssr	NOUN
admet-2753	328	32	(	(	PUNCT
admet-2753	328	33	equation	equation	NOUN
admet-2753	328	34	(	(	PUNCT
admet-2753	328	35	23	23	NUM
admet-2753	328	36	)	)	PUNCT
admet-2753	328	37	)	)	PUNCT
admet-2753	328	38	,	,	PUNCT
admet-2753	328	39	when	when	SCONJ
admet-2753	328	40	the	the	DET
admet-2753	328	41	membrane	membrane	NOUN
admet-2753	328	42	dividing	divide	VERB
admet-2753	328	43	the	the	DET
admet-2753	328	44	two	two	NUM
admet-2753	328	45	uwl	uwl	NOUN
admet-2753	328	46	layers	layer	NOUN
admet-2753	328	47	only	only	ADV
admet-2753	328	48	lets	let	VERB
admet-2753	328	49	the	the	DET
admet-2753	328	50	drug	drug	NOUN
admet-2753	328	51	permeate	permeate	VERB
admet-2753	328	52	or	or	CCONJ
admet-2753	328	53	the	the	DET
admet-2753	328	54	permeation	permeation	NOUN
admet-2753	328	55	of	of	ADP
admet-2753	328	56	the	the	DET
admet-2753	328	57	solubilizing	solubilizing	NOUN
admet-2753	328	58	additive	additive	NOUN
admet-2753	328	59	is	be	AUX
admet-2753	328	60	quite	quite	ADV
admet-2753	328	61	slow	slow	ADJ
admet-2753	328	62	,	,	PUNCT
admet-2753	328	63	so	so	CCONJ
admet-2753	328	64	it	it	PRON
admet-2753	328	65	does	do	AUX
admet-2753	328	66	not	not	PART
admet-2753	328	67	affect	affect	VERB
admet-2753	328	68	the	the	DET
admet-2753	328	69	transport	transport	NOUN
admet-2753	328	70	of	of	ADP
admet-2753	328	71	the	the	DET
admet-2753	328	72	api	api	NOUN
admet-2753	328	73	substantially	substantially	ADV
admet-2753	328	74	.	.	PUNCT
admet-2753	329	1	only	only	ADV
admet-2753	329	2	in	in	ADP
admet-2753	329	3	the	the	DET
admet-2753	329	4	case	case	NOUN
admet-2753	329	5	of	of	ADP
admet-2753	329	6	the	the	DET
admet-2753	329	7	6	6	NUM
admet-2753	329	8	kda	kda	NOUN
admet-2753	329	9	membrane	membrane	NOUN
admet-2753	329	10	can	can	AUX
admet-2753	329	11	a	a	DET
admet-2753	329	12	significant	significant	ADJ
admet-2753	329	13	deviation	deviation	NOUN
admet-2753	329	14	be	be	AUX
admet-2753	329	15	observed	observe	VERB
admet-2753	329	16	from	from	ADP
admet-2753	329	17	the	the	DET
admet-2753	329	18	general	general	ADJ
admet-2753	329	19	model	model	NOUN
admet-2753	329	20	that	that	PRON
admet-2753	329	21	only	only	ADV
admet-2753	329	22	considers	consider	VERB
admet-2753	329	23	the	the	DET
admet-2753	329	24	drug	drug	NOUN
admet-2753	329	25	crossing	cross	VERB
admet-2753	329	26	through	through	ADP
admet-2753	329	27	the	the	DET
admet-2753	329	28	membrane	membrane	NOUN
admet-2753	329	29	due	due	ADP
admet-2753	329	30	to	to	ADP
admet-2753	329	31	the	the	DET
admet-2753	329	32	amount	amount	NOUN
admet-2753	329	33	of	of	ADP
admet-2753	329	34	cd	cd	NOUN
admet-2753	329	35	crossing	cross	VERB
admet-2753	329	36	the	the	DET
admet-2753	329	37	6	6	NUM
admet-2753	329	38	kda	kda	NOUN
admet-2753	329	39	size	size	NOUN
admet-2753	329	40	-	-	PUNCT
admet-2753	329	41	exclusion	exclusion	NOUN
admet-2753	329	42	membrane	membrane	NOUN
admet-2753	329	43	.	.	PUNCT
admet-2753	330	1	figure	figure	NOUN
admet-2753	330	2	10	10	NUM
admet-2753	330	3	.	.	PUNCT
admet-2753	331	1	flux	flux	PROPN
admet-2753	331	2	vs.	vs.	ADP
admet-2753	331	3	ssr	ssr	ADJ
admet-2753	331	4	curves	curve	NOUN
admet-2753	331	5	in	in	ADP
admet-2753	331	6	ph	ph	ADJ
admet-2753	331	7	10	10	NUM
admet-2753	331	8	buffer	buffer	NOUN
admet-2753	331	9	with	with	ADP
admet-2753	331	10	250	250	NUM
admet-2753	331	11	rpm	rpm	ADJ
admet-2753	331	12	stirring	stirring	NOUN
admet-2753	331	13	rate	rate	NOUN
admet-2753	331	14	and	and	CCONJ
admet-2753	331	15	with	with	ADP
admet-2753	331	16	0	0	NUM
admet-2753	331	17	rpm	rpm	ADJ
admet-2753	331	18	stirring	stirring	NOUN
admet-2753	331	19	rate	rate	NOUN
admet-2753	331	20	,	,	PUNCT
admet-2753	331	21	in	in	ADP
admet-2753	331	22	case	case	NOUN
admet-2753	331	23	of	of	ADP
admet-2753	331	24	lipophilic	lipophilic	ADJ
admet-2753	331	25	membrane	membrane	NOUN
admet-2753	331	26	,	,	PUNCT
admet-2753	331	27	6	6	NUM
admet-2753	331	28	and	and	CCONJ
admet-2753	331	29	1	1	NUM
admet-2753	331	30	kda	kda	NOUN
admet-2753	331	31	size	size	NOUN
admet-2753	331	32	-	-	PUNCT
admet-2753	331	33	exclusion	exclusion	NOUN
admet-2753	331	34	membranes	membrane	NOUN
admet-2753	331	35	.	.	PUNCT
admet-2753	332	1	no	no	DET
admet-2753	332	2	hp	hp	PROPN
admet-2753	332	3	-	-	PUNCT
admet-2753	332	4	β	β	NOUN
admet-2753	332	5	-	-	NOUN
admet-2753	332	6	cd	cd	NOUN
admet-2753	332	7	present	present	NOUN
admet-2753	332	8	on	on	ADP
admet-2753	332	9	either	either	DET
admet-2753	332	10	side	side	NOUN
admet-2753	332	11	of	of	ADP
admet-2753	332	12	the	the	DET
admet-2753	332	13	membrane	membrane	NOUN
admet-2753	332	14	with	with	ADP
admet-2753	332	15	red	red	ADJ
admet-2753	332	16	dots	dot	NOUN
admet-2753	332	17	,	,	PUNCT
admet-2753	332	18	addition	addition	NOUN
admet-2753	332	19	of	of	ADP
admet-2753	332	20	hp	hp	NOUN
admet-2753	332	21	-	-	PUNCT
admet-2753	332	22	β	β	NOUN
admet-2753	332	23	-	-	NOUN
admet-2753	332	24	cd	cd	NOUN
admet-2753	332	25	to	to	PART
admet-2753	332	26	donor	donor	VERB
admet-2753	332	27	side	side	NOUN
admet-2753	332	28	with	with	ADP
admet-2753	332	29	green	green	ADJ
admet-2753	332	30	dots	dot	NOUN
admet-2753	332	31	.	.	PUNCT
admet-2753	333	1	f	f	X
admet-2753	333	2	lu	lu	PROPN
admet-2753	333	3	x	x	NOUN
admet-2753	333	4	,	,	PUNCT
admet-2753	333	5			NOUN
admet-2753	333	6	g	g	NOUN
admet-2753	333	7	m	m	NOUN
admet-2753	333	8	in	in	ADP
admet-2753	333	9	-1	-1	PROPN
admet-2753	334	1	c	c	NOUN
admet-2753	334	2	m	m	VERB
admet-2753	334	3	--2	--2	INTJ
admet-2753	334	4	f	f	PROPN
admet-2753	334	5	lu	lu	PROPN
admet-2753	334	6	x	x	NOUN
admet-2753	334	7	,	,	PUNCT
admet-2753	334	8			NOUN
admet-2753	334	9	g	g	NOUN
admet-2753	334	10	m	m	NOUN
admet-2753	334	11	in	in	ADP
admet-2753	334	12	-1	-1	PROPN
admet-2753	335	1	c	c	NOUN
admet-2753	335	2	m	m	VERB
admet-2753	335	3	--2	--2	INTJ
admet-2753	335	4	f	f	PROPN
admet-2753	335	5	lu	lu	PROPN
admet-2753	335	6	x	x	NOUN
admet-2753	335	7	,	,	PUNCT
admet-2753	335	8			NOUN
admet-2753	335	9	g	g	NOUN
admet-2753	335	10	m	m	NOUN
admet-2753	335	11	in	in	ADP
admet-2753	335	12	-1	-1	PROPN
admet-2753	336	1	c	c	NOUN
admet-2753	336	2	m	m	VERB
admet-2753	336	3	--2	--2	INTJ
admet-2753	336	4	f	f	PROPN
admet-2753	336	5	lu	lu	PROPN
admet-2753	336	6	x	x	NOUN
admet-2753	336	7	,	,	PUNCT
admet-2753	336	8			NOUN
admet-2753	336	9	g	g	NOUN
admet-2753	336	10	m	m	NOUN
admet-2753	336	11	in	in	ADP
admet-2753	336	12	-1	-1	PROPN
admet-2753	337	1	c	c	NOUN
admet-2753	337	2	m	m	VERB
admet-2753	337	3	--2	--2	INTJ
admet-2753	337	4	f	f	PROPN
admet-2753	337	5	lu	lu	PROPN
admet-2753	337	6	x	x	NOUN
admet-2753	337	7	,	,	PUNCT
admet-2753	337	8			NOUN
admet-2753	337	9	g	g	NOUN
admet-2753	337	10	m	m	NOUN
admet-2753	337	11	in	in	ADP
admet-2753	337	12	-1	-1	PROPN
admet-2753	338	1	c	c	NOUN
admet-2753	338	2	m	m	VERB
admet-2753	338	3	--2	--2	INTJ
admet-2753	338	4	f	f	PROPN
admet-2753	338	5	lu	lu	PROPN
admet-2753	338	6	x	x	NOUN
admet-2753	338	7	,	,	PUNCT
admet-2753	338	8			NOUN
admet-2753	338	9	g	g	NOUN
admet-2753	338	10	m	m	NOUN
admet-2753	338	11	in	in	ADP
admet-2753	338	12	-1	-1	PROPN
admet-2753	339	1	c	c	NOUN
admet-2753	339	2	m	m	NOUN
admet-2753	339	3	--2	--2	NOUN
admet-2753	339	4	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	PROPN
admet-2753	340	1	p.	p.	PROPN
admet-2753	340	2	tőzsér	tőzsér	PROPN
admet-2753	340	3	et	et	PROPN
admet-2753	340	4	al	al	PROPN
admet-2753	340	5	.	.	PROPN
admet-2753	340	6	admet	admet	PROPN
admet-2753	340	7	&	&	CCONJ
admet-2753	340	8	dmpk	dmpk	PROPN
admet-2753	340	9	13(4	13(4	NUM
admet-2753	340	10	)	)	PUNCT
admet-2753	340	11	(	(	PUNCT
admet-2753	340	12	2025	2025	NUM
admet-2753	340	13	)	)	PUNCT
admet-2753	340	14	2753	2753	NUM
admet-2753	340	15	18	18	NUM
admet-2753	340	16	conclusions	conclusion	NOUN
admet-2753	340	17	the	the	DET
admet-2753	340	18	comparative	comparative	ADJ
admet-2753	340	19	study	study	NOUN
admet-2753	340	20	of	of	ADP
admet-2753	340	21	lipophilic	lipophilic	ADJ
admet-2753	340	22	and	and	CCONJ
admet-2753	340	23	size	size	NOUN
admet-2753	340	24	-	-	PUNCT
admet-2753	340	25	exclusion	exclusion	NOUN
admet-2753	340	26	membranes	membrane	NOUN
admet-2753	340	27	in	in	ADP
admet-2753	340	28	in	in	ADP
admet-2753	340	29	vitro	vitro	X
admet-2753	340	30	side	side	NOUN
admet-2753	340	31	-	-	PUNCT
admet-2753	340	32	by	by	ADP
admet-2753	340	33	-	-	PUNCT
admet-2753	340	34	side	side	NOUN
admet-2753	340	35	diffusion	diffusion	NOUN
admet-2753	340	36	cell	cell	NOUN
admet-2753	340	37	assays	assay	NOUN
admet-2753	340	38	in	in	ADP
admet-2753	340	39	the	the	DET
admet-2753	340	40	presence	presence	NOUN
admet-2753	340	41	of	of	ADP
admet-2753	340	42	cyclodextrins	cyclodextrin	NOUN
admet-2753	340	43	presents	present	VERB
admet-2753	340	44	a	a	DET
admet-2753	340	45	comprehensive	comprehensive	ADJ
admet-2753	340	46	evaluation	evaluation	NOUN
admet-2753	340	47	of	of	ADP
admet-2753	340	48	the	the	DET
admet-2753	340	49	mechanisms	mechanism	NOUN
admet-2753	340	50	underlying	underlie	VERB
admet-2753	340	51	drug	drug	NOUN
admet-2753	340	52	transport	transport	NOUN
admet-2753	340	53	.	.	PUNCT
admet-2753	341	1	the	the	DET
admet-2753	341	2	research	research	NOUN
admet-2753	341	3	focused	focus	VERB
admet-2753	341	4	on	on	ADP
admet-2753	341	5	carvedilol	carvedilol	NOUN
admet-2753	341	6	as	as	ADP
admet-2753	341	7	the	the	DET
admet-2753	341	8	model	model	NOUN
admet-2753	341	9	drug	drug	NOUN
admet-2753	341	10	and	and	CCONJ
admet-2753	341	11	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	341	12	-	-	PUNCT
admet-2753	341	13	beta	beta	NOUN
admet-2753	341	14	-	-	PUNCT
admet-2753	341	15	cyclodextrin	cyclodextrin	NOUN
admet-2753	341	16	as	as	ADP
admet-2753	341	17	the	the	DET
admet-2753	341	18	model	model	NOUN
admet-2753	341	19	solubilizing	solubilize	VERB
admet-2753	341	20	agent	agent	NOUN
admet-2753	341	21	,	,	PUNCT
admet-2753	341	22	aiming	aim	VERB
admet-2753	341	23	to	to	PART
admet-2753	341	24	understand	understand	VERB
admet-2753	341	25	the	the	DET
admet-2753	341	26	differences	difference	NOUN
admet-2753	341	27	in	in	ADP
admet-2753	341	28	permeability	permeability	NOUN
admet-2753	341	29	and	and	CCONJ
admet-2753	341	30	solubility	solubility	NOUN
admet-2753	341	31	when	when	SCONJ
admet-2753	341	32	using	use	VERB
admet-2753	341	33	these	these	DET
admet-2753	341	34	two	two	NUM
admet-2753	341	35	types	type	NOUN
admet-2753	341	36	of	of	ADP
admet-2753	341	37	membranes	membrane	NOUN
admet-2753	341	38	.	.	PUNCT
admet-2753	342	1	the	the	DET
admet-2753	342	2	solubility	solubility	NOUN
admet-2753	342	3	measurements	measurement	NOUN
admet-2753	342	4	indicated	indicate	VERB
admet-2753	342	5	that	that	SCONJ
admet-2753	342	6	hp	hp	PROPN
admet-2753	342	7	-	-	PUNCT
admet-2753	342	8	β	β	NOUN
admet-2753	342	9	-	-	NOUN
admet-2753	342	10	cd	cd	NOUN
admet-2753	342	11	effectively	effectively	ADV
admet-2753	342	12	increased	increase	VERB
admet-2753	342	13	the	the	DET
admet-2753	342	14	solubility	solubility	NOUN
admet-2753	342	15	of	of	ADP
admet-2753	342	16	car	car	NOUN
admet-2753	342	17	for	for	ADP
admet-2753	342	18	both	both	DET
admet-2753	342	19	polymorph	polymorph	NOUN
admet-2753	342	20	forms	form	NOUN
admet-2753	342	21	,	,	PUNCT
admet-2753	342	22	suggesting	suggest	VERB
admet-2753	342	23	its	its	PRON
admet-2753	342	24	role	role	NOUN
admet-2753	342	25	in	in	ADP
admet-2753	342	26	enhancing	enhance	VERB
admet-2753	342	27	drug	drug	NOUN
admet-2753	342	28	solubility	solubility	NOUN
admet-2753	342	29	.	.	PUNCT
admet-2753	343	1	the	the	DET
admet-2753	343	2	phase	phase	NOUN
admet-2753	343	3	solubility	solubility	NOUN
admet-2753	343	4	diagram	diagram	NOUN
admet-2753	343	5	further	far	ADV
admet-2753	343	6	confirmed	confirm	VERB
admet-2753	343	7	that	that	SCONJ
admet-2753	343	8	car	car	NOUN
admet-2753	343	9	forms	form	VERB
admet-2753	343	10	a	a	DET
admet-2753	343	11	1:1	1:1	NUM
admet-2753	343	12	stoichiometric	stoichiometric	NOUN
admet-2753	343	13	complex	complex	NOUN
admet-2753	343	14	with	with	ADP
admet-2753	343	15	hp	hp	PROPN
admet-2753	343	16	-	-	PUNCT
admet-2753	343	17	β	β	NOUN
admet-2753	343	18	-	-	NOUN
admet-2753	343	19	cd	cd	NOUN
admet-2753	343	20	.	.	PUNCT
admet-2753	344	1	the	the	DET
admet-2753	344	2	transport	transport	NOUN
admet-2753	344	3	of	of	ADP
admet-2753	344	4	hp	hp	PROPN
admet-2753	344	5	-	-	PUNCT
admet-2753	344	6	β	β	NOUN
admet-2753	344	7	-	-	NOUN
admet-2753	344	8	cd	cd	NOUN
admet-2753	344	9	through	through	ADP
admet-2753	344	10	the	the	DET
admet-2753	344	11	lipophilic	lipophilic	ADJ
admet-2753	344	12	membrane	membrane	NOUN
admet-2753	344	13	was	be	AUX
admet-2753	344	14	negligible	negligible	ADJ
admet-2753	344	15	.	.	PUNCT
admet-2753	345	1	in	in	ADP
admet-2753	345	2	contrast	contrast	NOUN
admet-2753	345	3	,	,	PUNCT
admet-2753	345	4	it	it	PRON
admet-2753	345	5	was	be	AUX
admet-2753	345	6	substantial	substantial	ADJ
admet-2753	345	7	through	through	ADP
admet-2753	345	8	the	the	DET
admet-2753	345	9	size	size	NOUN
admet-2753	345	10	-	-	PUNCT
admet-2753	345	11	exclusion	exclusion	NOUN
admet-2753	345	12	membrane	membrane	NOUN
admet-2753	345	13	,	,	PUNCT
admet-2753	345	14	highlighting	highlight	VERB
admet-2753	345	15	a	a	DET
admet-2753	345	16	key	key	ADJ
admet-2753	345	17	difference	difference	NOUN
admet-2753	345	18	between	between	ADP
admet-2753	345	19	the	the	DET
admet-2753	345	20	two	two	NUM
admet-2753	345	21	types	type	NOUN
admet-2753	345	22	of	of	ADP
admet-2753	345	23	membrane	membrane	NOUN
admet-2753	345	24	.	.	PUNCT
admet-2753	346	1	in	in	ADP
admet-2753	346	2	vitro	vitro	X
admet-2753	346	3	side	side	NOUN
admet-2753	346	4	-	-	PUNCT
admet-2753	346	5	by	by	ADP
admet-2753	346	6	-	-	PUNCT
admet-2753	346	7	side	side	NOUN
admet-2753	346	8	diffusion	diffusion	NOUN
admet-2753	346	9	cell	cell	NOUN
admet-2753	346	10	assays	assay	NOUN
admet-2753	346	11	provided	provide	VERB
admet-2753	346	12	valuable	valuable	ADJ
admet-2753	346	13	insight	insight	NOUN
admet-2753	346	14	into	into	ADP
admet-2753	346	15	how	how	SCONJ
admet-2753	346	16	hp	hp	VERB
admet-2753	346	17	-	-	PUNCT
admet-2753	346	18	β	β	NOUN
admet-2753	346	19	-	-	ADJ
admet-2753	346	20	cd	cd	NOUN
admet-2753	346	21	influences	influence	NOUN
admet-2753	346	22	drug	drug	NOUN
admet-2753	346	23	transport	transport	NOUN
admet-2753	346	24	across	across	ADP
admet-2753	346	25	these	these	DET
admet-2753	346	26	membranes	membrane	NOUN
admet-2753	346	27	.	.	PUNCT
admet-2753	347	1	the	the	DET
admet-2753	347	2	presence	presence	NOUN
admet-2753	347	3	of	of	ADP
admet-2753	347	4	hp	hp	PROPN
admet-2753	347	5	-	-	PUNCT
admet-2753	347	6	β	β	NOUN
admet-2753	347	7	-	-	NOUN
admet-2753	347	8	cd	cd	NOUN
admet-2753	347	9	on	on	ADP
admet-2753	347	10	the	the	DET
admet-2753	347	11	donor	donor	NOUN
admet-2753	347	12	side	side	NOUN
admet-2753	347	13	generally	generally	ADV
admet-2753	347	14	reduced	reduce	VERB
admet-2753	347	15	permeability	permeability	NOUN
admet-2753	347	16	due	due	ADP
admet-2753	347	17	to	to	ADP
admet-2753	347	18	increased	increase	VERB
admet-2753	347	19	drug	drug	NOUN
admet-2753	347	20	solubility	solubility	NOUN
admet-2753	347	21	and	and	CCONJ
admet-2753	347	22	decreased	decrease	VERB
admet-2753	347	23	free	free	ADJ
admet-2753	347	24	drug	drug	NOUN
admet-2753	347	25	concentration	concentration	NOUN
admet-2753	347	26	;	;	PUNCT
admet-2753	347	27	with	with	ADP
admet-2753	347	28	this	this	PRON
admet-2753	347	29	,	,	PUNCT
admet-2753	347	30	the	the	DET
admet-2753	347	31	solubility	solubility	NOUN
admet-2753	347	32	-	-	PUNCT
admet-2753	347	33	permeability	permeability	NOUN
admet-2753	347	34	interplay	interplay	NOUN
admet-2753	347	35	was	be	AUX
admet-2753	347	36	well	well	ADV
admet-2753	347	37	displayed	display	VERB
admet-2753	347	38	in	in	ADP
admet-2753	347	39	the	the	DET
admet-2753	347	40	case	case	NOUN
admet-2753	347	41	of	of	ADP
admet-2753	347	42	both	both	DET
admet-2753	347	43	membrane	membrane	ADJ
admet-2753	347	44	types	type	NOUN
admet-2753	347	45	.	.	PUNCT
admet-2753	348	1	in	in	ADP
admet-2753	348	2	conclusion	conclusion	NOUN
admet-2753	348	3	,	,	PUNCT
admet-2753	348	4	using	use	VERB
admet-2753	348	5	a	a	DET
admet-2753	348	6	non	non	ADJ
admet-2753	348	7	-	-	ADJ
admet-2753	348	8	stirred	stirred	ADJ
admet-2753	348	9	environment	environment	NOUN
admet-2753	348	10	caused	cause	VERB
admet-2753	348	11	the	the	DET
admet-2753	348	12	absolute	absolute	ADJ
admet-2753	348	13	papp	papp	NOUN
admet-2753	348	14	values	value	NOUN
admet-2753	348	15	to	to	PART
admet-2753	348	16	be	be	AUX
admet-2753	348	17	similar	similar	ADJ
admet-2753	348	18	in	in	ADP
admet-2753	348	19	the	the	DET
admet-2753	348	20	case	case	NOUN
admet-2753	348	21	of	of	ADP
admet-2753	348	22	all	all	DET
admet-2753	348	23	three	three	NUM
admet-2753	348	24	membranes	membrane	NOUN
admet-2753	348	25	.	.	PUNCT
admet-2753	349	1	however	however	ADV
admet-2753	349	2	,	,	PUNCT
admet-2753	349	3	since	since	SCONJ
admet-2753	349	4	non	non	ADJ
admet-2753	349	5	-	-	ADJ
admet-2753	349	6	stirring	stirring	ADJ
admet-2753	349	7	significantly	significantly	ADV
admet-2753	349	8	reduces	reduce	VERB
admet-2753	349	9	the	the	DET
admet-2753	349	10	effect	effect	NOUN
admet-2753	349	11	of	of	ADP
admet-2753	349	12	solubilizing	solubilize	VERB
admet-2753	349	13	agents	agent	NOUN
admet-2753	349	14	for	for	ADP
admet-2753	349	15	all	all	DET
admet-2753	349	16	three	three	NUM
admet-2753	349	17	membranes	membrane	NOUN
admet-2753	349	18	,	,	PUNCT
admet-2753	349	19	stirring	stirring	NOUN
admet-2753	349	20	is	be	AUX
admet-2753	349	21	essential	essential	ADJ
admet-2753	349	22	to	to	PART
admet-2753	349	23	observe	observe	VERB
admet-2753	349	24	excipient	excipient	ADJ
admet-2753	349	25	effects	effect	NOUN
admet-2753	349	26	reliably	reliably	ADV
admet-2753	349	27	.	.	PUNCT
admet-2753	350	1	therefore	therefore	ADV
admet-2753	350	2	,	,	PUNCT
admet-2753	350	3	stirring	stir	VERB
admet-2753	350	4	remains	remain	VERB
admet-2753	350	5	crucial	crucial	ADJ
admet-2753	350	6	for	for	ADP
admet-2753	350	7	assessing	assess	VERB
admet-2753	350	8	the	the	DET
admet-2753	350	9	impact	impact	NOUN
admet-2753	350	10	of	of	ADP
admet-2753	350	11	formulation	formulation	NOUN
admet-2753	350	12	additives	additive	NOUN
admet-2753	350	13	on	on	ADP
admet-2753	350	14	permeability	permeability	NOUN
admet-2753	350	15	and	and	CCONJ
admet-2753	350	16	for	for	ADP
admet-2753	350	17	the	the	DET
admet-2753	350	18	comparison	comparison	NOUN
admet-2753	350	19	of	of	ADP
admet-2753	350	20	different	different	ADJ
admet-2753	350	21	drug	drug	NOUN
admet-2753	350	22	formulations	formulation	NOUN
admet-2753	350	23	containing	contain	VERB
admet-2753	350	24	the	the	DET
admet-2753	350	25	same	same	ADJ
admet-2753	350	26	api	api	NOUN
admet-2753	350	27	.	.	PUNCT
admet-2753	351	1	the	the	DET
admet-2753	351	2	supersaturation	supersaturation	NOUN
admet-2753	351	3	ratio	ratio	NOUN
admet-2753	351	4	,	,	PUNCT
admet-2753	351	5	defined	define	VERB
admet-2753	351	6	as	as	ADP
admet-2753	351	7	the	the	DET
admet-2753	351	8	ratio	ratio	NOUN
admet-2753	351	9	of	of	ADP
admet-2753	351	10	the	the	DET
admet-2753	351	11	drug	drug	NOUN
admet-2753	351	12	concentration	concentration	NOUN
admet-2753	351	13	present	present	ADJ
admet-2753	351	14	in	in	ADP
admet-2753	351	15	solution	solution	NOUN
admet-2753	351	16	to	to	ADP
admet-2753	351	17	its	its	PRON
admet-2753	351	18	thermodynamic	thermodynamic	ADJ
admet-2753	351	19	solubility	solubility	NOUN
admet-2753	351	20	measured	measure	VERB
admet-2753	351	21	in	in	ADP
admet-2753	351	22	exactly	exactly	ADV
admet-2753	351	23	the	the	DET
admet-2753	351	24	same	same	ADJ
admet-2753	351	25	media	medium	NOUN
admet-2753	351	26	.	.	PUNCT
admet-2753	352	1	was	be	AUX
admet-2753	352	2	found	find	VERB
admet-2753	352	3	to	to	PART
admet-2753	352	4	be	be	AUX
admet-2753	352	5	the	the	DET
admet-2753	352	6	driving	drive	VERB
admet-2753	352	7	force	force	NOUN
admet-2753	352	8	of	of	ADP
admet-2753	352	9	membrane	membrane	NOUN
admet-2753	352	10	transport	transport	NOUN
admet-2753	352	11	due	due	ADP
admet-2753	352	12	to	to	ADP
admet-2753	352	13	a	a	DET
admet-2753	352	14	concentration	concentration	NOUN
admet-2753	352	15	-	-	PUNCT
admet-2753	352	16	based	base	VERB
admet-2753	352	17	mathematical	mathematical	ADJ
admet-2753	352	18	description	description	NOUN
admet-2753	352	19	.	.	PUNCT
admet-2753	353	1	this	this	DET
admet-2753	353	2	mathematical	mathematical	ADJ
admet-2753	353	3	description	description	NOUN
admet-2753	353	4	was	be	AUX
admet-2753	353	5	also	also	ADV
admet-2753	353	6	supported	support	VERB
admet-2753	353	7	with	with	ADP
admet-2753	353	8	experimental	experimental	ADJ
admet-2753	353	9	data	datum	NOUN
admet-2753	353	10	for	for	ADP
admet-2753	353	11	lipophilic	lipophilic	ADJ
admet-2753	353	12	and	and	CCONJ
admet-2753	353	13	1kda	1kda	NUM
admet-2753	353	14	mwco	mwco	NOUN
admet-2753	353	15	size	size	NOUN
admet-2753	353	16	-	-	PUNCT
admet-2753	353	17	exclusion	exclusion	NOUN
admet-2753	353	18	membranes	membrane	NOUN
admet-2753	353	19	with	with	ADP
admet-2753	353	20	the	the	DET
admet-2753	353	21	transport	transport	NOUN
admet-2753	353	22	of	of	ADP
admet-2753	353	23	carvedilol	carvedilol	NOUN
admet-2753	353	24	and	and	CCONJ
admet-2753	353	25	hp	hp	PROPN
admet-2753	353	26	-	-	PUNCT
admet-2753	353	27	β	β	NOUN
admet-2753	353	28	-	-	NOUN
admet-2753	353	29	cd	cd	NOUN
admet-2753	353	30	,	,	PUNCT
admet-2753	353	31	when	when	SCONJ
admet-2753	353	32	the	the	DET
admet-2753	353	33	permeation	permeation	NOUN
admet-2753	353	34	of	of	ADP
admet-2753	353	35	the	the	DET
admet-2753	353	36	solubilizing	solubilizing	NOUN
admet-2753	353	37	additive	additive	NOUN
admet-2753	353	38	is	be	AUX
admet-2753	353	39	quite	quite	ADV
admet-2753	353	40	slow	slow	ADJ
admet-2753	353	41	,	,	PUNCT
admet-2753	353	42	so	so	CCONJ
admet-2753	353	43	it	it	PRON
admet-2753	353	44	does	do	AUX
admet-2753	353	45	not	not	PART
admet-2753	353	46	affect	affect	VERB
admet-2753	353	47	the	the	DET
admet-2753	353	48	transport	transport	NOUN
admet-2753	353	49	of	of	ADP
admet-2753	353	50	the	the	DET
admet-2753	353	51	api	api	NOUN
admet-2753	353	52	substantially	substantially	ADV
admet-2753	353	53	.	.	PUNCT
admet-2753	354	1	overall	overall	ADV
admet-2753	354	2	,	,	PUNCT
admet-2753	354	3	the	the	DET
admet-2753	354	4	similar	similar	ADJ
admet-2753	354	5	driving	driving	NOUN
admet-2753	354	6	force	force	NOUN
admet-2753	354	7	across	across	ADP
admet-2753	354	8	lipophilic	lipophilic	ADJ
admet-2753	354	9	membranes	membrane	NOUN
admet-2753	354	10	and	and	CCONJ
admet-2753	354	11	via	via	ADP
admet-2753	354	12	1	1	NUM
admet-2753	354	13	kda	kda	NOUN
admet-2753	354	14	mwco	mwco	NOUN
admet-2753	354	15	size	size	NOUN
admet-2753	354	16	-	-	PUNCT
admet-2753	354	17	exclusion	exclusion	NOUN
admet-2753	354	18	membranes	membrane	NOUN
admet-2753	354	19	provides	provide	VERB
admet-2753	354	20	a	a	DET
admet-2753	354	21	robust	robust	ADJ
admet-2753	354	22	platform	platform	NOUN
admet-2753	354	23	for	for	ADP
admet-2753	354	24	assessing	assess	VERB
admet-2753	354	25	drug	drug	NOUN
admet-2753	354	26	permeability	permeability	NOUN
admet-2753	354	27	.	.	PUNCT
admet-2753	355	1	this	this	PRON
admet-2753	355	2	can	can	AUX
admet-2753	355	3	streamline	streamline	VERB
admet-2753	355	4	the	the	DET
admet-2753	355	5	drug	drug	NOUN
admet-2753	355	6	development	development	NOUN
admet-2753	355	7	process	process	NOUN
admet-2753	355	8	by	by	ADP
admet-2753	355	9	reducing	reduce	VERB
admet-2753	355	10	the	the	DET
admet-2753	355	11	reliance	reliance	NOUN
admet-2753	355	12	on	on	ADP
admet-2753	355	13	more	more	ADV
admet-2753	355	14	complex	complex	ADJ
admet-2753	355	15	and	and	CCONJ
admet-2753	355	16	challenging	challenging	ADJ
admet-2753	355	17	cell	cell	NOUN
admet-2753	355	18	-	-	PUNCT
admet-2753	355	19	based	base	VERB
admet-2753	355	20	models	model	NOUN
admet-2753	355	21	,	,	PUNCT
admet-2753	355	22	offering	offer	VERB
admet-2753	355	23	a	a	DET
admet-2753	355	24	more	more	ADV
admet-2753	355	25	practical	practical	ADJ
admet-2753	355	26	approach	approach	NOUN
admet-2753	355	27	to	to	ADP
admet-2753	355	28	pharmaceutical	pharmaceutical	NOUN
admet-2753	355	29	research	research	NOUN
admet-2753	355	30	and	and	CCONJ
admet-2753	355	31	development	development	NOUN
admet-2753	355	32	.	.	PUNCT
admet-2753	356	1	future	future	ADJ
admet-2753	356	2	research	research	NOUN
admet-2753	356	3	could	could	AUX
admet-2753	356	4	refine	refine	VERB
admet-2753	356	5	these	these	DET
admet-2753	356	6	findings	finding	NOUN
admet-2753	356	7	by	by	ADP
admet-2753	356	8	exploring	explore	VERB
admet-2753	356	9	a	a	DET
admet-2753	356	10	wider	wide	ADJ
admet-2753	356	11	range	range	NOUN
admet-2753	356	12	of	of	ADP
admet-2753	356	13	drugs	drug	NOUN
admet-2753	356	14	and	and	CCONJ
admet-2753	356	15	solubilizing	solubilize	VERB
admet-2753	356	16	agents	agent	NOUN
admet-2753	356	17	,	,	PUNCT
admet-2753	356	18	ultimately	ultimately	ADV
admet-2753	356	19	enhancing	enhance	VERB
admet-2753	356	20	the	the	DET
admet-2753	356	21	predictive	predictive	ADJ
admet-2753	356	22	power	power	NOUN
admet-2753	356	23	and	and	CCONJ
admet-2753	356	24	applicability	applicability	NOUN
admet-2753	356	25	of	of	ADP
admet-2753	356	26	size	size	NOUN
admet-2753	356	27	-	-	PUNCT
admet-2753	356	28	exclusion	exclusion	NOUN
admet-2753	356	29	membranes	membrane	NOUN
admet-2753	356	30	in	in	ADP
admet-2753	356	31	pharmaceutical	pharmaceutical	ADJ
admet-2753	356	32	sciences	science	NOUN
admet-2753	356	33	.	.	PUNCT
admet-2753	357	1	supplementary	supplementary	ADJ
admet-2753	357	2	material	material	NOUN
admet-2753	357	3	additional	additional	ADJ
admet-2753	357	4	data	datum	NOUN
admet-2753	357	5	are	be	AUX
admet-2753	357	6	available	available	ADJ
admet-2753	357	7	at	at	ADP
admet-2753	357	8	https://pub.iapchem.org/ojs/index.php/admet/article/view/2753	https://pub.iapchem.org/ojs/index.php/admet/article/view/2753	NOUN
admet-2753	357	9	,	,	PUNCT
admet-2753	357	10	or	or	CCONJ
admet-2753	357	11	from	from	ADP
admet-2753	357	12	the	the	DET
admet-2753	357	13	corresponding	corresponding	ADJ
admet-2753	357	14	author	author	NOUN
admet-2753	357	15	on	on	ADP
admet-2753	357	16	request	request	NOUN
admet-2753	357	17	.	.	PUNCT
admet-2753	358	1	acknowledgements	acknowledgement	NOUN
admet-2753	358	2	:	:	PUNCT
admet-2753	358	3	this	this	DET
admet-2753	358	4	work	work	NOUN
admet-2753	358	5	was	be	AUX
admet-2753	358	6	supported	support	VERB
admet-2753	358	7	by	by	ADP
admet-2753	358	8	eköp-24	eköp-24	PROPN
admet-2753	358	9	-	-	PUNCT
admet-2753	358	10	4	4	NUM
admet-2753	358	11	-	-	PUNCT
admet-2753	358	12	i	i	PRON
admet-2753	358	13	-	-	PUNCT
admet-2753	358	14	bme-127	bme-127	PROPN
admet-2753	358	15	university	university	PROPN
admet-2753	358	16	research	research	NOUN
admet-2753	358	17	fellowship	fellowship	NOUN
admet-2753	358	18	programme	programme	NOUN
admet-2753	358	19	of	of	ADP
admet-2753	358	20	the	the	DET
admet-2753	358	21	ministry	ministry	PROPN
admet-2753	358	22	for	for	ADP
admet-2753	358	23	culture	culture	NOUN
admet-2753	358	24	and	and	CCONJ
admet-2753	358	25	innovation	innovation	NOUN
admet-2753	358	26	from	from	ADP
admet-2753	358	27	the	the	DET
admet-2753	358	28	source	source	NOUN
admet-2753	358	29	of	of	ADP
admet-2753	358	30	the	the	DET
admet-2753	358	31	national	national	ADJ
admet-2753	358	32	research	research	NOUN
admet-2753	358	33	,	,	PUNCT
admet-2753	358	34	development	development	NOUN
admet-2753	358	35	and	and	CCONJ
admet-2753	358	36	innovation	innovation	NOUN
admet-2753	358	37	fund	fund	PROPN
admet-2753	358	38	.	.	PUNCT
admet-2753	359	1	project	project	PROPN
admet-2753	359	2	no	no	NOUN
admet-2753	359	3	.	.	PUNCT
admet-2753	359	4	tkp-9	tkp-9	NOUN
admet-2753	359	5	-	-	PUNCT
admet-2753	359	6	8	8	NUM
admet-2753	359	7	/	/	SYM
admet-2753	359	8	paly-2021	paly-2021	NOUN
admet-2753	359	9	has	have	AUX
admet-2753	359	10	been	be	AUX
admet-2753	359	11	implemented	implement	VERB
admet-2753	359	12	with	with	ADP
admet-2753	359	13	the	the	DET
admet-2753	359	14	support	support	NOUN
admet-2753	359	15	provided	provide	VERB
admet-2753	359	16	by	by	ADP
admet-2753	359	17	the	the	DET
admet-2753	359	18	ministry	ministry	PROPN
admet-2753	359	19	of	of	ADP
admet-2753	359	20	culture	culture	NOUN
admet-2753	359	21	and	and	CCONJ
admet-2753	359	22	innovation	innovation	NOUN
admet-2753	359	23	of	of	ADP
admet-2753	359	24	hungary	hungary	PROPN
admet-2753	359	25	from	from	ADP
admet-2753	359	26	the	the	DET
admet-2753	359	27	national	national	ADJ
admet-2753	359	28	research	research	NOUN
admet-2753	359	29	,	,	PUNCT
admet-2753	359	30	development	development	NOUN
admet-2753	359	31	and	and	CCONJ
admet-2753	359	32	innovation	innovation	NOUN
admet-2753	359	33	fund	fund	NOUN
admet-2753	359	34	,	,	PUNCT
admet-2753	359	35	financed	finance	VERB
admet-2753	359	36	under	under	ADP
admet-2753	359	37	the	the	DET
admet-2753	359	38	tkp2021	tkp2021	NOUN
admet-2753	359	39	-	-	PUNCT
admet-2753	359	40	ega	ega	NOUN
admet-2753	359	41	funding	funding	NOUN
admet-2753	359	42	scheme	scheme	NOUN
admet-2753	359	43	.	.	PUNCT
admet-2753	360	1	this	this	DET
admet-2753	360	2	work	work	NOUN
admet-2753	360	3	was	be	AUX
admet-2753	360	4	financially	financially	ADV
admet-2753	360	5	supported	support	VERB
admet-2753	360	6	by	by	ADP
admet-2753	360	7	the	the	DET
admet-2753	360	8	janos	janos	PROPN
admet-2753	360	9	bolyai	bolyai	PROPN
admet-2753	360	10	research	research	NOUN
admet-2753	360	11	scholarship	scholarship	NOUN
admet-2753	360	12	of	of	ADP
admet-2753	360	13	the	the	DET
admet-2753	360	14	hungarian	hungarian	ADJ
admet-2753	360	15	academy	academy	PROPN
admet-2753	360	16	of	of	ADP
admet-2753	360	17	sciences	sciences	PROPN
admet-2753	360	18	.	.	PUNCT
admet-2753	361	1	project	project	PROPN
admet-2753	361	2	no	no	NOUN
admet-2753	361	3	.	.	NOUN
admet-2753	362	1	2024	2024	NUM
admet-2753	362	2	-	-	PUNCT
admet-2753	362	3	1.1.1	1.1.1	NUM
admet-2753	362	4	-	-	PUNCT
admet-2753	362	5	kkv_fókusz2024	kkv_fókusz2024	NOUN
admet-2753	362	6	-	-	PUNCT
admet-2753	362	7	00051	00051	NUM
admet-2753	362	8	has	have	AUX
admet-2753	362	9	been	be	AUX
admet-2753	362	10	implemented	implement	VERB
admet-2753	362	11	with	with	ADP
admet-2753	362	12	the	the	DET
admet-2753	362	13	support	support	NOUN
admet-2753	362	14	provided	provide	VERB
admet-2753	362	15	by	by	ADP
admet-2753	362	16	the	the	DET
admet-2753	362	17	ministry	ministry	PROPN
admet-2753	362	18	of	of	ADP
admet-2753	362	19	culture	culture	NOUN
admet-2753	362	20	and	and	CCONJ
admet-2753	362	21	innovation	innovation	NOUN
admet-2753	362	22	of	of	ADP
admet-2753	362	23	hungary	hungary	PROPN
admet-2753	362	24	from	from	ADP
admet-2753	362	25	the	the	DET
admet-2753	362	26	national	national	ADJ
admet-2753	362	27	research	research	NOUN
admet-2753	362	28	,	,	PUNCT
admet-2753	362	29	development	development	NOUN
admet-2753	362	30	and	and	CCONJ
admet-2753	362	31	innovation	innovation	NOUN
admet-2753	362	32	fund	fund	NOUN
admet-2753	362	33	,	,	PUNCT
admet-2753	362	34	financed	finance	VERB
admet-2753	362	35	under	under	ADP
admet-2753	362	36	the	the	DET
admet-2753	362	37	„	„	PUNCT
admet-2753	362	38	kkv	kkv	VERB
admet-2753	362	39	fókuszterületi	fókuszterületi	ADJ
admet-2753	362	40	innovációs	innovációs	ADJ
admet-2753	362	41	program	program	NOUN
admet-2753	362	42	”	"	PUNCT
admet-2753	362	43	funding	funding	NOUN
admet-2753	362	44	scheme	scheme	NOUN
admet-2753	362	45	.	.	PUNCT
admet-2753	363	1	conflict	conflict	NOUN
admet-2753	363	2	of	of	ADP
admet-2753	363	3	interest	interest	NOUN
admet-2753	363	4	:	:	PUNCT
admet-2753	363	5	the	the	DET
admet-2753	363	6	authors	author	NOUN
admet-2753	363	7	declare	declare	VERB
admet-2753	363	8	no	no	DET
admet-2753	363	9	conflict	conflict	NOUN
admet-2753	363	10	of	of	ADP
admet-2753	363	11	interest	interest	NOUN
admet-2753	363	12	.	.	PUNCT
admet-2753	364	1	https://pub.iapchem.org/ojs/index.php/admet/article/view/2753	https://pub.iapchem.org/ojs/index.php/admet/article/view/2753	X
admet-2753	364	2	admet	admet	PROPN
admet-2753	364	3	&	&	CCONJ
admet-2753	364	4	dmpk	dmpk	PROPN
admet-2753	364	5	13(4	13(4	NUM
admet-2753	364	6	)	)	PUNCT
admet-2753	364	7	(	(	PUNCT
admet-2753	364	8	2025	2025	NUM
admet-2753	364	9	)	)	PUNCT
admet-2753	364	10	2753	2753	NUM
admet-2753	364	11	comparison	comparison	NOUN
admet-2753	364	12	of	of	ADP
admet-2753	364	13	lipophilic	lipophilic	ADJ
admet-2753	364	14	and	and	CCONJ
admet-2753	364	15	size	size	NOUN
admet-2753	364	16	-	-	PUNCT
admet-2753	364	17	exclusion	exclusion	NOUN
admet-2753	364	18	membranes	membrane	NOUN
admet-2753	364	19	doi	doi	NOUN
admet-2753	364	20	:	:	PUNCT
admet-2753	364	21	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	364	22	19	19	NUM
admet-2753	364	23	references	reference	NOUN
admet-2753	364	24	[	[	X
admet-2753	364	25	1	1	NUM
admet-2753	364	26	]	]	PUNCT
admet-2753	364	27	p.	p.	PROPN
admet-2753	364	28	berben	berben	PROPN
admet-2753	364	29	,	,	PUNCT
admet-2753	364	30	e.	e.	PROPN
admet-2753	364	31	borbás	borbás	PROPN
admet-2753	364	32	,	,	PUNCT
admet-2753	364	33	intestinal	intestinal	ADJ
admet-2753	364	34	drug	drug	NOUN
admet-2753	364	35	absorption	absorption	NOUN
admet-2753	364	36	:	:	PUNCT
admet-2753	364	37	cell	cell	NOUN
admet-2753	364	38	-	-	PUNCT
admet-2753	364	39	free	free	ADJ
admet-2753	364	40	permeation	permeation	NOUN
admet-2753	364	41	systems	system	NOUN
admet-2753	364	42	,	,	PUNCT
admet-2753	364	43	in	in	ADP
admet-2753	364	44	drug	drug	NOUN
admet-2753	364	45	discovery	discovery	NOUN
admet-2753	364	46	and	and	CCONJ
admet-2753	364	47	evaluation	evaluation	NOUN
admet-2753	364	48	:	:	PUNCT
admet-2753	364	49	safety	safety	NOUN
admet-2753	364	50	and	and	CCONJ
admet-2753	364	51	pharmacokinetic	pharmacokinetic	ADJ
admet-2753	364	52	assays	assay	NOUN
admet-2753	364	53	,	,	PUNCT
admet-2753	364	54	f.j	f.j	PROPN
admet-2753	364	55	.	.	PROPN
admet-2753	364	56	hock	hock	NOUN
admet-2753	364	57	,	,	PUNCT
admet-2753	364	58	m.r	m.r	PROPN
admet-2753	364	59	.	.	PROPN
admet-2753	364	60	gralinski	gralinski	PROPN
admet-2753	364	61	,	,	PUNCT
admet-2753	364	62	m.k	m.k	PROPN
admet-2753	364	63	.	.	PROPN
admet-2753	364	64	pugsley	pugsley	PROPN
admet-2753	364	65	(	(	PUNCT
admet-2753	364	66	eds	eds	PROPN
admet-2753	364	67	.	.	PUNCT
admet-2753	364	68	)	)	PUNCT
admet-2753	364	69	,	,	PUNCT
admet-2753	364	70	springer	springer	NOUN
admet-2753	364	71	international	international	ADJ
admet-2753	364	72	publishing	publishing	NOUN
admet-2753	364	73	,	,	PUNCT
admet-2753	364	74	cham	cham	NOUN
admet-2753	364	75	,	,	PUNCT
admet-2753	364	76	2022	2022	NUM
admet-2753	364	77	,	,	PUNCT
admet-2753	364	78	p.	p.	NOUN
admet-2753	364	79	1	1	NUM
admet-2753	364	80	-	-	SYM
admet-2753	364	81	29	29	NUM
admet-2753	364	82	.	.	PUNCT
admet-2753	365	1	https://doi.org/10.1007/978-3-030-73317-9_95-1	https://doi.org/10.1007/978-3-030-73317-9_95-1	PUNCT
admet-2753	366	1	[	[	X
admet-2753	366	2	2	2	NUM
admet-2753	366	3	]	]	PUNCT
admet-2753	366	4	p.	p.	PROPN
admet-2753	366	5	berben	berben	PROPN
admet-2753	366	6	,	,	PUNCT
admet-2753	366	7	a.	a.	PROPN
admet-2753	366	8	bauer	bauer	PROPN
admet-2753	366	9	-	-	PUNCT
admet-2753	366	10	brandl	brandl	PROPN
admet-2753	366	11	,	,	PUNCT
admet-2753	366	12	m.	m.	NOUN
admet-2753	366	13	brandl	brandl	PROPN
admet-2753	366	14	,	,	PUNCT
admet-2753	366	15	b.	b.	PROPN
admet-2753	366	16	faller	faller	PROPN
admet-2753	366	17	,	,	PUNCT
admet-2753	366	18	g.e	g.e	PROPN
admet-2753	366	19	.	.	PROPN
admet-2753	366	20	flaten	flaten	PROPN
admet-2753	366	21	,	,	PUNCT
admet-2753	366	22	a.-c	a.-c	PROPN
admet-2753	366	23	.	.	PUNCT
admet-2753	367	1	jacobsen	jacobsen	PROPN
admet-2753	367	2	,	,	PUNCT
admet-2753	367	3	j.	j.	PROPN
admet-2753	367	4	brouwers	brouwers	PROPN
admet-2753	367	5	,	,	PUNCT
admet-2753	367	6	p.	p.	NOUN
admet-2753	367	7	augustijns	augustijns	NOUN
admet-2753	367	8	.	.	PUNCT
admet-2753	368	1	drug	drug	NOUN
admet-2753	368	2	permeability	permeability	NOUN
admet-2753	368	3	profiling	profiling	NOUN
admet-2753	368	4	using	use	VERB
admet-2753	368	5	cell	cell	NOUN
admet-2753	368	6	-	-	PUNCT
admet-2753	368	7	free	free	ADJ
admet-2753	368	8	permeation	permeation	NOUN
admet-2753	368	9	tools	tool	NOUN
admet-2753	368	10	:	:	PUNCT
admet-2753	368	11	overview	overview	NOUN
admet-2753	368	12	and	and	CCONJ
admet-2753	368	13	applications	application	NOUN
admet-2753	368	14	.	.	PUNCT
admet-2753	369	1	european	european	ADJ
admet-2753	369	2	journal	journal	PROPN
admet-2753	369	3	of	of	ADP
admet-2753	369	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	369	5	sciences	science	NOUN
admet-2753	369	6	119	119	NUM
admet-2753	369	7	(	(	PUNCT
admet-2753	369	8	2018	2018	NUM
admet-2753	369	9	)	)	PUNCT
admet-2753	369	10	219	219	NUM
admet-2753	369	11	-	-	SYM
admet-2753	369	12	233	233	NUM
admet-2753	369	13	.	.	PUNCT
admet-2753	370	1	https://doi.org/https://doi.org/10.1016/j.ejps.2018.04.016	https://doi.org/https://doi.org/10.1016/j.ejps.2018.04.016	PROPN
admet-2753	371	1	[	[	X
admet-2753	371	2	3	3	NUM
admet-2753	371	3	]	]	PUNCT
admet-2753	371	4	a.	a.	NOUN
admet-2753	371	5	adhikari	adhikari	PROPN
admet-2753	371	6	,	,	PUNCT
admet-2753	371	7	p.r	p.r	PROPN
admet-2753	371	8	.	.	PROPN
admet-2753	371	9	seo	seo	PROPN
admet-2753	371	10	,	,	PUNCT
admet-2753	371	11	j.e	j.e	PROPN
admet-2753	371	12	.	.	PROPN
admet-2753	371	13	polli	polli	PROPN
admet-2753	371	14	.	.	PUNCT
admet-2753	372	1	characterization	characterization	NOUN
admet-2753	372	2	of	of	ADP
admet-2753	372	3	dissolution	dissolution	NOUN
admet-2753	372	4	-	-	PUNCT
admet-2753	372	5	permeation	permeation	NOUN
admet-2753	372	6	system	system	NOUN
admet-2753	372	7	using	use	VERB
admet-2753	372	8	hollow	hollow	ADJ
admet-2753	372	9	fiber	fiber	NOUN
admet-2753	372	10	membrane	membrane	NOUN
admet-2753	372	11	module	module	NOUN
admet-2753	372	12	and	and	CCONJ
admet-2753	372	13	utility	utility	NOUN
admet-2753	372	14	to	to	PART
admet-2753	372	15	predict	predict	VERB
admet-2753	372	16	in	in	ADP
admet-2753	372	17	vivo	vivo	ADJ
admet-2753	372	18	drug	drug	NOUN
admet-2753	372	19	permeation	permeation	NOUN
admet-2753	372	20	across	across	ADP
admet-2753	372	21	bcs	bcs	NOUN
admet-2753	372	22	classes	class	NOUN
admet-2753	372	23	.	.	PUNCT
admet-2753	373	1	journal	journal	NOUN
admet-2753	373	2	of	of	ADP
admet-2753	373	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	373	4	sciences	science	NOUN
admet-2753	373	5	111	111	NUM
admet-2753	373	6	(	(	PUNCT
admet-2753	373	7	2022	2022	NUM
admet-2753	373	8	)	)	PUNCT
admet-2753	373	9	3075	3075	NUM
admet-2753	373	10	-	-	SYM
admet-2753	373	11	3087	3087	NUM
admet-2753	373	12	.	.	PUNCT
admet-2753	374	1	https://doi.org/10.1016/j.xphs.2022.07.002	https://doi.org/10.1016/j.xphs.2022.07.002	NOUN
admet-2753	374	2	[	[	X
admet-2753	374	3	4	4	X
admet-2753	374	4	]	]	X
admet-2753	374	5	e.	e.	PROPN
admet-2753	374	6	borbás	borbás	PROPN
admet-2753	374	7	,	,	PUNCT
admet-2753	374	8	a.	a.	PROPN
admet-2753	374	9	balogh	balogh	PROPN
admet-2753	374	10	,	,	PUNCT
admet-2753	374	11	k.	k.	PROPN
admet-2753	374	12	bocz	bocz	PROPN
admet-2753	374	13	,	,	PUNCT
admet-2753	374	14	j.	j.	PROPN
admet-2753	374	15	müller	müller	PROPN
admet-2753	374	16	,	,	PUNCT
admet-2753	374	17	é	é	PROPN
admet-2753	374	18	.	.	PUNCT
admet-2753	374	19	kiserdei	kiserdei	PROPN
admet-2753	374	20	,	,	PUNCT
admet-2753	374	21	t.	t.	PROPN
admet-2753	374	22	vigh	vigh	PROPN
admet-2753	374	23	,	,	PUNCT
admet-2753	374	24	b.	b.	PROPN
admet-2753	374	25	sinkó	sinkó	PROPN
admet-2753	374	26	,	,	PUNCT
admet-2753	374	27	a.	a.	NOUN
admet-2753	374	28	marosi	marosi	PROPN
admet-2753	374	29	,	,	PUNCT
admet-2753	374	30	a.	a.	NOUN
admet-2753	374	31	halász	halász	PROPN
admet-2753	374	32	,	,	PUNCT
admet-2753	374	33	z.	z.	PROPN
admet-2753	374	34	dohányos	dohányos	PROPN
admet-2753	374	35	,	,	PUNCT
admet-2753	374	36	l.	l.	NOUN
admet-2753	374	37	szente	szente	PROPN
admet-2753	374	38	,	,	PUNCT
admet-2753	374	39	g.t	g.t	PROPN
admet-2753	374	40	.	.	PROPN
admet-2753	374	41	balogh	balogh	PROPN
admet-2753	374	42	,	,	PUNCT
admet-2753	374	43	z.k	z.k	PROPN
admet-2753	374	44	.	.	PROPN
admet-2753	374	45	nagy	nagy	PROPN
admet-2753	374	46	.	.	PUNCT
admet-2753	375	1	in	in	ADP
admet-2753	375	2	vitro	vitro	X
admet-2753	375	3	dissolution	dissolution	NOUN
admet-2753	375	4	-	-	PUNCT
admet-2753	375	5	permeation	permeation	NOUN
admet-2753	375	6	evaluation	evaluation	NOUN
admet-2753	375	7	of	of	ADP
admet-2753	375	8	an	an	DET
admet-2753	375	9	electrospun	electrospun	NOUN
admet-2753	375	10	cyclodextrin	cyclodextrin	NOUN
admet-2753	375	11	-	-	PUNCT
admet-2753	375	12	based	base	VERB
admet-2753	375	13	formulation	formulation	NOUN
admet-2753	375	14	of	of	ADP
admet-2753	375	15	aripiprazole	aripiprazole	NOUN
admet-2753	375	16	using	use	VERB
admet-2753	375	17	μflux	μflux	NOUN
admet-2753	375	18	™	™	NOUN
admet-2753	375	19	.	.	PUNCT
admet-2753	376	1	international	international	ADJ
admet-2753	376	2	journal	journal	PROPN
admet-2753	376	3	of	of	ADP
admet-2753	376	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	376	5	491	491	NUM
admet-2753	376	6	(	(	PUNCT
admet-2753	376	7	2015	2015	NUM
admet-2753	376	8	)	)	PUNCT
admet-2753	376	9	180	180	NUM
admet-2753	376	10	-	-	SYM
admet-2753	376	11	189	189	NUM
admet-2753	376	12	.	.	PUNCT
admet-2753	377	1	https://doi.org/10.1016/j.ijpharm.2015.06.019	https://doi.org/10.1016/j.ijpharm.2015.06.019	NUM
admet-2753	377	2	[	[	X
admet-2753	377	3	5	5	NUM
admet-2753	377	4	]	]	PUNCT
admet-2753	377	5	a.	a.	NOUN
admet-2753	377	6	avdeef	avdeef	PROPN
admet-2753	377	7	,	,	PUNCT
admet-2753	377	8	m.	m.	PROPN
admet-2753	377	9	strafford	strafford	PROPN
admet-2753	377	10	,	,	PUNCT
admet-2753	377	11	e.	e.	PROPN
admet-2753	377	12	block	block	PROPN
admet-2753	377	13	,	,	PUNCT
admet-2753	377	14	m.p	m.p	PROPN
admet-2753	377	15	.	.	PROPN
admet-2753	377	16	balogh	balogh	PROPN
admet-2753	377	17	,	,	PUNCT
admet-2753	377	18	w.	w.	PROPN
admet-2753	377	19	chambliss	chambliss	PROPN
admet-2753	377	20	,	,	PUNCT
admet-2753	377	21	i.	i.	PROPN
admet-2753	377	22	khan	khan	PROPN
admet-2753	377	23	.	.	PUNCT
admet-2753	378	1	drug	drug	NOUN
admet-2753	378	2	absorption	absorption	NOUN
admet-2753	378	3	in	in	ADP
admet-2753	378	4	vitro	vitro	X
admet-2753	378	5	model	model	NOUN
admet-2753	378	6	:	:	PUNCT
admet-2753	378	7	filter	filter	NOUN
admet-2753	378	8	-	-	PUNCT
admet-2753	378	9	immobilized	immobilized	ADJ
admet-2753	378	10	artificial	artificial	ADJ
admet-2753	378	11	membranes	membrane	NOUN
admet-2753	378	12	.	.	PUNCT
admet-2753	379	1	2	2	X
admet-2753	379	2	.	.	X
admet-2753	379	3	studies	study	NOUN
admet-2753	379	4	of	of	ADP
admet-2753	379	5	the	the	DET
admet-2753	379	6	permeability	permeability	NOUN
admet-2753	379	7	properties	property	NOUN
admet-2753	379	8	of	of	ADP
admet-2753	379	9	lactones	lactone	NOUN
admet-2753	379	10	in	in	ADP
admet-2753	379	11	piper	piper	NOUN
admet-2753	379	12	methysticum	methysticum	PROPN
admet-2753	379	13	forst	forst	PROPN
admet-2753	379	14	.	.	PUNCT
admet-2753	380	1	european	european	PROPN
admet-2753	380	2	journal	journal	PROPN
admet-2753	380	3	of	of	ADP
admet-2753	380	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	380	5	sciences	science	NOUN
admet-2753	380	6	14	14	NUM
admet-2753	380	7	(	(	PUNCT
admet-2753	380	8	2001	2001	NUM
admet-2753	380	9	)	)	PUNCT
admet-2753	380	10	271	271	NUM
admet-2753	380	11	-	-	SYM
admet-2753	380	12	280	280	NUM
admet-2753	380	13	.	.	PUNCT
admet-2753	381	1	https://doi.org/10.1016/s0928-0987(01)00191-9	https://doi.org/10.1016/s0928-0987(01)00191-9	NOUN
admet-2753	382	1	[	[	X
admet-2753	382	2	6	6	NUM
admet-2753	382	3	]	]	PUNCT
admet-2753	382	4	b.	b.	NOUN
admet-2753	382	5	sinkó	sinkó	PROPN
admet-2753	382	6	,	,	PUNCT
admet-2753	382	7	t.m	t.m	PROPN
admet-2753	382	8	.	.	PROPN
admet-2753	382	9	garrigues	garrigues	PROPN
admet-2753	382	10	,	,	PUNCT
admet-2753	382	11	g.t	g.t	PROPN
admet-2753	382	12	.	.	PROPN
admet-2753	382	13	balogh	balogh	PROPN
admet-2753	382	14	,	,	PUNCT
admet-2753	382	15	z.k	z.k	PROPN
admet-2753	382	16	.	.	PROPN
admet-2753	382	17	nagy	nagy	PROPN
admet-2753	382	18	,	,	PUNCT
admet-2753	382	19	o.	o.	PROPN
admet-2753	382	20	tsinman	tsinman	NOUN
admet-2753	382	21	,	,	PUNCT
admet-2753	382	22	a.	a.	PROPN
admet-2753	382	23	avdeef	avdeef	PROPN
admet-2753	382	24	,	,	PUNCT
admet-2753	382	25	k.	k.	PROPN
admet-2753	382	26	takács	takács	PROPN
admet-2753	382	27	-	-	PUNCT
admet-2753	382	28	novák	novák	PROPN
admet-2753	382	29	.	.	PROPN
admet-2753	382	30	skinpampa	skinpampa	PROPN
admet-2753	382	31	:	:	PUNCT
admet-2753	382	32	a	a	DET
admet-2753	382	33	new	new	ADJ
admet-2753	382	34	method	method	NOUN
admet-2753	382	35	for	for	ADP
admet-2753	382	36	fast	fast	ADJ
admet-2753	382	37	prediction	prediction	NOUN
admet-2753	382	38	of	of	ADP
admet-2753	382	39	skin	skin	NOUN
admet-2753	382	40	penetration	penetration	NOUN
admet-2753	382	41	.	.	PUNCT
admet-2753	383	1	european	european	PROPN
admet-2753	383	2	journal	journal	PROPN
admet-2753	383	3	of	of	ADP
admet-2753	383	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	383	5	sciences	science	NOUN
admet-2753	383	6	45	45	NUM
admet-2753	383	7	(	(	PUNCT
admet-2753	383	8	2012	2012	NUM
admet-2753	383	9	)	)	PUNCT
admet-2753	383	10	698	698	NUM
admet-2753	383	11	-	-	SYM
admet-2753	383	12	707	707	NUM
admet-2753	383	13	.	.	PUNCT
admet-2753	384	1	https://doi.org/10.1016/j.ejps.2012.01.011	https://doi.org/10.1016/j.ejps.2012.01.011	NOUN
admet-2753	384	2	[	[	X
admet-2753	384	3	7	7	X
admet-2753	384	4	]	]	X
admet-2753	384	5	g.e	g.e	PROPN
admet-2753	384	6	.	.	PROPN
admet-2753	384	7	flaten	flaten	PROPN
admet-2753	384	8	,	,	PUNCT
admet-2753	384	9	a.b	a.b	PROPN
admet-2753	384	10	.	.	NOUN
admet-2753	384	11	dhanikula	dhanikula	PROPN
admet-2753	384	12	,	,	PUNCT
admet-2753	384	13	k.	k.	PROPN
admet-2753	384	14	luthman	luthman	PROPN
admet-2753	384	15	,	,	PUNCT
admet-2753	384	16	m.	m.	NOUN
admet-2753	384	17	brandl	brandl	PROPN
admet-2753	384	18	.	.	PUNCT
admet-2753	385	1	drug	drug	NOUN
admet-2753	385	2	permeability	permeability	NOUN
admet-2753	385	3	across	across	ADP
admet-2753	385	4	a	a	DET
admet-2753	385	5	phospholipid	phospholipid	NOUN
admet-2753	385	6	vesicle	vesicle	NOUN
admet-2753	385	7	based	base	VERB
admet-2753	385	8	barrier	barrier	NOUN
admet-2753	385	9	:	:	PUNCT
admet-2753	385	10	a	a	DET
admet-2753	385	11	novel	novel	ADJ
admet-2753	385	12	approach	approach	NOUN
admet-2753	385	13	for	for	ADP
admet-2753	385	14	studying	study	VERB
admet-2753	385	15	passive	passive	ADJ
admet-2753	385	16	diffusion	diffusion	NOUN
admet-2753	385	17	.	.	PUNCT
admet-2753	386	1	european	european	PROPN
admet-2753	386	2	journal	journal	PROPN
admet-2753	386	3	of	of	ADP
admet-2753	386	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	386	5	sciences	science	NOUN
admet-2753	386	6	27	27	NUM
admet-2753	386	7	(	(	PUNCT
admet-2753	386	8	2006	2006	NUM
admet-2753	386	9	)	)	PUNCT
admet-2753	386	10	80	80	NUM
admet-2753	386	11	-	-	SYM
admet-2753	386	12	90	90	NUM
admet-2753	386	13	.	.	PUNCT
admet-2753	387	1	https://doi.org/10.1016/j.ejps.2005.08.007	https://doi.org/10.1016/j.ejps.2005.08.007	NOUN
admet-2753	387	2	[	[	X
admet-2753	387	3	8	8	NUM
admet-2753	387	4	]	]	X
admet-2753	387	5	m.	m.	NOUN
admet-2753	387	6	di	di	X
admet-2753	387	7	cagno	cagno	PROPN
admet-2753	387	8	,	,	PUNCT
admet-2753	387	9	h.a	h.a	PROPN
admet-2753	387	10	.	.	PROPN
admet-2753	387	11	bibi	bibi	PROPN
admet-2753	387	12	,	,	PUNCT
admet-2753	387	13	a.	a.	PROPN
admet-2753	387	14	bauer	bauer	PROPN
admet-2753	387	15	-	-	PUNCT
admet-2753	387	16	brandl	brandl	PROPN
admet-2753	387	17	.	.	PUNCT
admet-2753	388	1	new	new	ADJ
admet-2753	388	2	biomimetic	biomimetic	ADJ
admet-2753	388	3	barrier	barrier	NOUN
admet-2753	388	4	permeapad	permeapad	NOUN
admet-2753	388	5	™	™	NOUN
admet-2753	388	6	for	for	ADP
admet-2753	388	7	efficient	efficient	ADJ
admet-2753	388	8	investigation	investigation	NOUN
admet-2753	388	9	of	of	ADP
admet-2753	388	10	passive	passive	ADJ
admet-2753	388	11	permeability	permeability	NOUN
admet-2753	388	12	of	of	ADP
admet-2753	388	13	drugs	drug	NOUN
admet-2753	388	14	.	.	PUNCT
admet-2753	389	1	european	european	ADJ
admet-2753	389	2	journal	journal	PROPN
admet-2753	389	3	of	of	ADP
admet-2753	389	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	389	5	sciences	science	NOUN
admet-2753	389	6	73	73	NUM
admet-2753	389	7	(	(	PUNCT
admet-2753	389	8	2015	2015	NUM
admet-2753	389	9	)	)	PUNCT
admet-2753	389	10	29	29	NUM
admet-2753	389	11	-	-	SYM
admet-2753	389	12	34	34	NUM
admet-2753	389	13	.	.	PUNCT
admet-2753	390	1	https://doi.org/10.1016/j.ejps.2015.03.019	https://doi.org/10.1016/j.ejps.2015.03.019	PROPN
admet-2753	391	1	[	[	X
admet-2753	391	2	9	9	NUM
admet-2753	391	3	]	]	PUNCT
admet-2753	391	4	a.	a.	NOUN
admet-2753	391	5	avdeef	avdeef	PROPN
admet-2753	391	6	,	,	PUNCT
admet-2753	391	7	absorption	absorption	NOUN
admet-2753	391	8	and	and	CCONJ
admet-2753	391	9	drug	drug	NOUN
admet-2753	391	10	development	development	NOUN
admet-2753	391	11	:	:	PUNCT
admet-2753	391	12	solubility	solubility	NOUN
admet-2753	391	13	,	,	PUNCT
admet-2753	391	14	permeability	permeability	NOUN
admet-2753	391	15	,	,	PUNCT
admet-2753	391	16	and	and	CCONJ
admet-2753	391	17	charge	charge	NOUN
admet-2753	391	18	state	state	NOUN
admet-2753	391	19	;	;	PUNCT
admet-2753	391	20	2nd	2nd	ADJ
admet-2753	391	21	ed	ed	NOUN
admet-2753	391	22	,	,	PUNCT
admet-2753	391	23	john	john	PROPN
admet-2753	391	24	wiley	wiley	PROPN
admet-2753	391	25	and	and	CCONJ
admet-2753	391	26	sons	son	NOUN
admet-2753	391	27	:	:	PUNCT
admet-2753	391	28	united	united	PROPN
admet-2753	391	29	states	states	PROPN
admet-2753	391	30	.	.	PUNCT
admet-2753	392	1	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	PRON
admet-2753	393	1	[	[	X
admet-2753	393	2	10	10	NUM
admet-2753	393	3	]	]	PUNCT
admet-2753	393	4	k.	k.	PROPN
admet-2753	393	5	sugano	sugano	PROPN
admet-2753	393	6	,	,	PUNCT
admet-2753	393	7	biopharmaceutics	biopharmaceutics	NOUN
admet-2753	393	8	modeling	modeling	NOUN
admet-2753	393	9	and	and	CCONJ
admet-2753	393	10	simulations	simulation	NOUN
admet-2753	393	11	:	:	PUNCT
admet-2753	393	12	theory	theory	NOUN
admet-2753	393	13	,	,	PUNCT
admet-2753	393	14	practice	practice	NOUN
admet-2753	393	15	,	,	PUNCT
admet-2753	393	16	methods	method	NOUN
admet-2753	393	17	,	,	PUNCT
admet-2753	393	18	and	and	CCONJ
admet-2753	393	19	applications	application	NOUN
admet-2753	393	20	,	,	PUNCT
admet-2753	393	21	john	john	PROPN
admet-2753	393	22	wiley	wiley	PROPN
admet-2753	393	23	&	&	CCONJ
admet-2753	393	24	sons	son	NOUN
admet-2753	393	25	,	,	PUNCT
admet-2753	393	26	2012	2012	NUM
admet-2753	393	27	.	.	PUNCT
admet-2753	394	1	https://doi.org/10.1002/9781118354339.ch7	https://doi.org/10.1002/9781118354339.ch7	PROPN
admet-2753	394	2	[	[	X
admet-2753	394	3	11	11	NUM
admet-2753	394	4	]	]	PUNCT
admet-2753	394	5	a.	a.	NOUN
admet-2753	394	6	avdeef	avdeef	PROPN
admet-2753	394	7	.	.	PUNCT
admet-2753	395	1	the	the	DET
admet-2753	395	2	rise	rise	NOUN
admet-2753	395	3	of	of	ADP
admet-2753	395	4	pampa	pampa	NOUN
admet-2753	395	5	.	.	PUNCT
admet-2753	396	1	expert	expert	NOUN
admet-2753	396	2	opin	opin	NOUN
admet-2753	396	3	drug	drug	NOUN
admet-2753	396	4	metab	metab	NOUN
admet-2753	396	5	toxicol	toxicol	NOUN
admet-2753	396	6	1	1	NUM
admet-2753	396	7	(	(	PUNCT
admet-2753	396	8	2005	2005	NUM
admet-2753	396	9	)	)	PUNCT
admet-2753	396	10	325	325	NUM
admet-2753	396	11	-	-	SYM
admet-2753	396	12	342	342	NUM
admet-2753	396	13	.	.	PUNCT
admet-2753	397	1	https://doi.org/10.1517/17425255.1.2.325	https://doi.org/10.1517/17425255.1.2.325	NOUN
admet-2753	398	1	[	[	X
admet-2753	398	2	12	12	NUM
admet-2753	398	3	]	]	X
admet-2753	398	4	b.	b.	PROPN
admet-2753	398	5	faller	faller	PROPN
admet-2753	398	6	.	.	PUNCT
admet-2753	399	1	artificial	artificial	ADJ
admet-2753	399	2	membrane	membrane	NOUN
admet-2753	399	3	assays	assay	NOUN
admet-2753	399	4	to	to	PART
admet-2753	399	5	assess	assess	VERB
admet-2753	399	6	permeability	permeability	NOUN
admet-2753	399	7	.	.	PUNCT
admet-2753	400	1	current	current	ADJ
admet-2753	400	2	drug	drug	NOUN
admet-2753	400	3	metabolism	metabolism	NOUN
admet-2753	400	4	9	9	NUM
admet-2753	400	5	(	(	PUNCT
admet-2753	400	6	2008	2008	NUM
admet-2753	400	7	)	)	PUNCT
admet-2753	400	8	886892	886892	NUM
admet-2753	400	9	.	.	PUNCT
admet-2753	401	1	https://doi.org/10.2174/138920008786485227	https://doi.org/10.2174/138920008786485227	PUNCT
admet-2753	402	1	[	[	X
admet-2753	402	2	13	13	NUM
admet-2753	402	3	]	]	PUNCT
admet-2753	402	4	m.	m.	NOUN
admet-2753	402	5	kansy	kansy	PROPN
admet-2753	402	6	,	,	PUNCT
admet-2753	402	7	f.	f.	PROPN
admet-2753	402	8	senner	senner	PROPN
admet-2753	402	9	,	,	PUNCT
admet-2753	402	10	k.	k.	PROPN
admet-2753	402	11	gubernator	gubernator	PROPN
admet-2753	402	12	.	.	PUNCT
admet-2753	403	1	physicochemical	physicochemical	ADJ
admet-2753	403	2	high	high	ADJ
admet-2753	403	3	throughput	throughput	NOUN
admet-2753	403	4	screening	screening	NOUN
admet-2753	403	5	:	:	PUNCT
admet-2753	403	6	parallel	parallel	ADJ
admet-2753	403	7	artificial	artificial	ADJ
admet-2753	403	8	membrane	membrane	NOUN
admet-2753	403	9	permeation	permeation	NOUN
admet-2753	403	10	assay	assay	VERB
admet-2753	403	11	in	in	ADP
admet-2753	403	12	the	the	DET
admet-2753	403	13	description	description	NOUN
admet-2753	403	14	of	of	ADP
admet-2753	403	15	passive	passive	ADJ
admet-2753	403	16	absorption	absorption	NOUN
admet-2753	403	17	processes	process	NOUN
admet-2753	403	18	.	.	PUNCT
admet-2753	404	1	journal	journal	NOUN
admet-2753	404	2	of	of	ADP
admet-2753	404	3	medicinal	medicinal	ADJ
admet-2753	404	4	chemistry	chemistry	NOUN
admet-2753	404	5	41	41	NUM
admet-2753	404	6	(	(	PUNCT
admet-2753	404	7	1998	1998	NUM
admet-2753	404	8	)	)	PUNCT
admet-2753	404	9	1007	1007	NUM
admet-2753	404	10	-	-	SYM
admet-2753	404	11	1010	1010	NUM
admet-2753	404	12	.	.	PUNCT
admet-2753	405	1	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	PROPN
admet-2753	406	1	[	[	X
admet-2753	406	2	14	14	NUM
admet-2753	406	3	]	]	X
admet-2753	406	4	d.	d.	PROPN
admet-2753	406	5	riethorst	riethorst	PROPN
admet-2753	406	6	,	,	PUNCT
admet-2753	406	7	j.	j.	PROPN
admet-2753	406	8	brouwers	brouwers	PROPN
admet-2753	406	9	,	,	PUNCT
admet-2753	406	10	j.	j.	PROPN
admet-2753	406	11	motmans	motmans	PROPN
admet-2753	406	12	,	,	PUNCT
admet-2753	406	13	p.	p.	NOUN
admet-2753	406	14	augustijns	augustijns	NOUN
admet-2753	406	15	.	.	PUNCT
admet-2753	407	1	human	human	ADJ
admet-2753	407	2	intestinal	intestinal	ADJ
admet-2753	407	3	fluid	fluid	NOUN
admet-2753	407	4	factors	factor	NOUN
admet-2753	407	5	affecting	affect	VERB
admet-2753	407	6	intestinal	intestinal	ADJ
admet-2753	407	7	drug	drug	NOUN
admet-2753	407	8	permeation	permeation	NOUN
admet-2753	407	9	in	in	ADP
admet-2753	407	10	vitro	vitro	X
admet-2753	407	11	.	.	PUNCT
admet-2753	408	1	european	european	ADJ
admet-2753	408	2	journal	journal	PROPN
admet-2753	408	3	of	of	ADP
admet-2753	408	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	408	5	sciences	science	NOUN
admet-2753	408	6	121	121	NUM
admet-2753	408	7	(	(	PUNCT
admet-2753	408	8	2018	2018	NUM
admet-2753	408	9	)	)	PUNCT
admet-2753	408	10	338	338	NUM
admet-2753	408	11	-	-	SYM
admet-2753	408	12	346	346	NUM
admet-2753	408	13	.	.	PUNCT
admet-2753	409	1	https://doi.org/https://doi.org/10.1016/j.ejps.2018.06.007	https://doi.org/https://doi.org/10.1016/j.ejps.2018.06.007	VERB
admet-2753	410	1	[	[	X
admet-2753	410	2	15	15	NUM
admet-2753	410	3	]	]	X
admet-2753	410	4	j.b	j.b	PROPN
admet-2753	410	5	.	.	PUNCT
admet-2753	410	6	eriksen	eriksen	PROPN
admet-2753	410	7	,	,	PUNCT
admet-2753	410	8	j.j	j.j	PROPN
admet-2753	410	9	.	.	PROPN
admet-2753	410	10	christiansen	christiansen	PROPN
admet-2753	410	11	,	,	PUNCT
admet-2753	410	12	a.	a.	PROPN
admet-2753	410	13	bauer	bauer	PROPN
admet-2753	410	14	-	-	PUNCT
admet-2753	410	15	brandl	brandl	PROPN
admet-2753	410	16	,	,	PUNCT
admet-2753	410	17	m.	m.	NOUN
admet-2753	410	18	ruponen	ruponen	PROPN
admet-2753	410	19	,	,	PUNCT
admet-2753	410	20	j.	j.	PROPN
admet-2753	410	21	rautio	rautio	PROPN
admet-2753	410	22	,	,	PUNCT
admet-2753	410	23	m.	m.	NOUN
admet-2753	410	24	brandl	brandl	PROPN
admet-2753	410	25	.	.	PUNCT
admet-2753	411	1	in	in	ADP
admet-2753	411	2	-	-	PUNCT
admet-2753	411	3	vitro	vitro	X
admet-2753	411	4	dynamic	dynamic	ADJ
admet-2753	411	5	dissolution	dissolution	NOUN
admet-2753	411	6	/	/	SYM
admet-2753	411	7	bioconversion	bioconversion	NOUN
admet-2753	411	8	/	/	SYM
admet-2753	411	9	permeation	permeation	NOUN
admet-2753	411	10	of	of	ADP
admet-2753	411	11	fosamprenavir	fosamprenavir	PROPN
admet-2753	411	12	using	use	VERB
admet-2753	411	13	a	a	DET
admet-2753	411	14	novel	novel	ADJ
admet-2753	411	15	tool	tool	NOUN
admet-2753	411	16	with	with	ADP
admet-2753	411	17	an	an	DET
admet-2753	411	18	artificial	artificial	ADJ
admet-2753	411	19	biomimetic	biomimetic	ADJ
admet-2753	411	20	permeation	permeation	NOUN
admet-2753	411	21	barrier	barrier	NOUN
admet-2753	411	22	and	and	CCONJ
admet-2753	411	23	microdialysis	microdialysis	NOUN
admet-2753	411	24	-	-	PUNCT
admet-2753	411	25	sampling	sampling	NOUN
admet-2753	411	26	.	.	PUNCT
admet-2753	412	1	european	european	ADJ
admet-2753	412	2	journal	journal	PROPN
admet-2753	412	3	of	of	ADP
admet-2753	412	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	412	5	sciences	science	NOUN
admet-2753	412	6	181	181	NUM
admet-2753	412	7	(	(	PUNCT
admet-2753	412	8	2023	2023	NUM
admet-2753	412	9	)	)	PUNCT
admet-2753	412	10	106366	106366	NUM
admet-2753	412	11	.	.	PUNCT
admet-2753	413	1	https://doi.org/10.1016/j.ejps.2022.106366	https://doi.org/10.1016/j.ejps.2022.106366	VERB
admet-2753	414	1	[	[	X
admet-2753	414	2	16	16	NUM
admet-2753	414	3	]	]	X
admet-2753	414	4	c.	c.	PROPN
admet-2753	414	5	washington	washington	PROPN
admet-2753	414	6	.	.	PUNCT
admet-2753	415	1	drug	drug	NOUN
admet-2753	415	2	release	release	NOUN
admet-2753	415	3	from	from	ADP
admet-2753	415	4	microdisperse	microdisperse	ADJ
admet-2753	415	5	systems	system	NOUN
admet-2753	415	6	:	:	PUNCT
admet-2753	415	7	a	a	DET
admet-2753	415	8	critical	critical	ADJ
admet-2753	415	9	review	review	NOUN
admet-2753	415	10	.	.	PUNCT
admet-2753	416	1	international	international	ADJ
admet-2753	416	2	journal	journal	PROPN
admet-2753	416	3	of	of	ADP
admet-2753	416	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	416	5	58	58	NUM
admet-2753	416	6	(	(	PUNCT
admet-2753	416	7	1990	1990	NUM
admet-2753	416	8	)	)	PUNCT
admet-2753	416	9	1	1	NUM
admet-2753	416	10	-	-	SYM
admet-2753	416	11	12	12	NUM
admet-2753	416	12	.	.	PUNCT
admet-2753	417	1	https://doi.org/10.1016/0378-5173(90)90280-h	https://doi.org/10.1016/0378-5173(90)90280-h	PROPN
admet-2753	418	1	[	[	X
admet-2753	418	2	17	17	NUM
admet-2753	418	3	]	]	PUNCT
admet-2753	418	4	p.	p.	NOUN
admet-2753	418	5	saokham	saokham	PROPN
admet-2753	418	6	,	,	PUNCT
admet-2753	418	7	a.	a.	PROPN
admet-2753	418	8	sá	sá	PROPN
admet-2753	418	9	couto	couto	PROPN
admet-2753	418	10	,	,	PUNCT
admet-2753	418	11	a.	a.	PROPN
admet-2753	418	12	ryzhakov	ryzhakov	PROPN
admet-2753	418	13	,	,	PUNCT
admet-2753	418	14	t.	t.	PROPN
admet-2753	418	15	loftsson	loftsson	NOUN
admet-2753	418	16	.	.	PUNCT
admet-2753	419	1	the	the	DET
admet-2753	419	2	self	self	NOUN
admet-2753	419	3	-	-	PUNCT
admet-2753	419	4	assemble	assemble	NOUN
admet-2753	419	5	of	of	ADP
admet-2753	419	6	natural	natural	ADJ
admet-2753	419	7	cyclodextrins	cyclodextrin	NOUN
admet-2753	419	8	in	in	ADP
admet-2753	419	9	aqueous	aqueous	ADJ
admet-2753	419	10	solutions	solution	NOUN
admet-2753	419	11	:	:	PUNCT
admet-2753	419	12	application	application	NOUN
admet-2753	419	13	of	of	ADP
admet-2753	419	14	miniature	miniature	ADJ
admet-2753	419	15	permeation	permeation	NOUN
admet-2753	419	16	studies	study	NOUN
admet-2753	419	17	for	for	ADP
admet-2753	419	18	critical	critical	ADJ
admet-2753	419	19	aggregation	aggregation	NOUN
admet-2753	419	20	concentration	concentration	NOUN
admet-2753	419	21	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	419	22	https://doi.org/10.1007/978-3-030-73317-9_95-1	https://doi.org/10.1007/978-3-030-73317-9_95-1	VERB
admet-2753	420	1	https://doi.org/https:/doi.org/10.1016/j.ejps.2018.04.016	https://doi.org/https:/doi.org/10.1016/j.ejps.2018.04.016	PROPN
admet-2753	420	2	https://doi.org/10.1016/j.xphs.2022.07.002	https://doi.org/10.1016/j.xphs.2022.07.002	NOUN
admet-2753	420	3	https://doi.org/10.1016/j.ijpharm.2015.06.019	https://doi.org/10.1016/j.ijpharm.2015.06.019	PUNCT
admet-2753	420	4	https://doi.org/10.1016/s0928-0987(01)00191-9	https://doi.org/10.1016/s0928-0987(01)00191-9	VERB
admet-2753	420	5	https://doi.org/10.1016/j.ejps.2012.01.011	https://doi.org/10.1016/j.ejps.2012.01.011	NOUN
admet-2753	420	6	https://doi.org/10.1016/j.ejps.2005.08.007	https://doi.org/10.1016/j.ejps.2005.08.007	NOUN
admet-2753	420	7	https://doi.org/10.1016/j.ejps.2015.03.019	https://doi.org/10.1016/j.ejps.2015.03.019	PUNCT
admet-2753	420	8	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	ADP
admet-2753	421	1	https://doi.org/10.1002/9781118354339.ch7	https://doi.org/10.1002/9781118354339.ch7	PROPN
admet-2753	421	2	https://doi.org/10.1517/17425255.1.2.325	https://doi.org/10.1517/17425255.1.2.325	PROPN
admet-2753	421	3	https://doi.org/10.2174/138920008786485227	https://doi.org/10.2174/138920008786485227	X
admet-2753	421	4	https://doi.org/10.1021/jm970530e	https://doi.org/10.1021/jm970530e	PROPN
admet-2753	421	5	https://doi.org/https:/doi.org/10.1016/j.ejps.2018.06.007	https://doi.org/https:/doi.org/10.1016/j.ejps.2018.06.007	VERB
admet-2753	421	6	https://doi.org/10.1016/j.ejps.2022.106366	https://doi.org/10.1016/j.ejps.2022.106366	VERB
admet-2753	421	7	https://doi.org/10.1016/0378-5173(90)90280-h	https://doi.org/10.1016/0378-5173(90)90280-h	PROPN
admet-2753	421	8	p.	p.	PROPN
admet-2753	421	9	tőzsér	tőzsér	PROPN
admet-2753	421	10	et	et	PROPN
admet-2753	421	11	al	al	PROPN
admet-2753	421	12	.	.	PROPN
admet-2753	421	13	admet	admet	PROPN
admet-2753	421	14	&	&	CCONJ
admet-2753	421	15	dmpk	dmpk	PROPN
admet-2753	421	16	13(4	13(4	NUM
admet-2753	421	17	)	)	PUNCT
admet-2753	421	18	(	(	PUNCT
admet-2753	421	19	2025	2025	NUM
admet-2753	421	20	)	)	PUNCT
admet-2753	421	21	2753	2753	NUM
admet-2753	421	22	20	20	NUM
admet-2753	421	23	(	(	PUNCT
admet-2753	421	24	cac	cac	PROPN
admet-2753	421	25	)	)	PUNCT
admet-2753	421	26	determinations	determination	NOUN
admet-2753	421	27	.	.	PUNCT
admet-2753	422	1	international	international	ADJ
admet-2753	422	2	journal	journal	PROPN
admet-2753	422	3	of	of	ADP
admet-2753	422	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	422	5	505	505	NUM
admet-2753	422	6	(	(	PUNCT
admet-2753	422	7	2016	2016	NUM
admet-2753	422	8	)	)	PUNCT
admet-2753	422	9	187	187	NUM
admet-2753	422	10	-	-	SYM
admet-2753	422	11	193	193	NUM
admet-2753	422	12	.	.	PUNCT
admet-2753	423	1	https://doi.org/10.1016/j.ijpharm.2016.03.049	https://doi.org/10.1016/j.ijpharm.2016.03.049	PROPN
admet-2753	423	2	[	[	X
admet-2753	423	3	18	18	NUM
admet-2753	423	4	]	]	X
admet-2753	423	5	j.	j.	PROPN
admet-2753	423	6	bouayed	bouaye	VERB
admet-2753	423	7	,	,	PUNCT
admet-2753	423	8	l.	l.	PROPN
admet-2753	423	9	hoffmann	hoffmann	PROPN
admet-2753	423	10	,	,	PUNCT
admet-2753	423	11	t.	t.	PROPN
admet-2753	423	12	bohn	bohn	PROPN
admet-2753	423	13	.	.	PUNCT
admet-2753	424	1	total	total	ADJ
admet-2753	424	2	phenolics	phenolic	NOUN
admet-2753	424	3	,	,	PUNCT
admet-2753	424	4	flavonoids	flavonoid	NOUN
admet-2753	424	5	,	,	PUNCT
admet-2753	424	6	anthocyanins	anthocyanin	NOUN
admet-2753	424	7	and	and	CCONJ
admet-2753	424	8	antioxidant	antioxidant	ADJ
admet-2753	424	9	activity	activity	NOUN
admet-2753	424	10	following	follow	VERB
admet-2753	424	11	simulated	simulate	VERB
admet-2753	424	12	gastro	gastro	NOUN
admet-2753	424	13	-	-	PUNCT
admet-2753	424	14	intestinal	intestinal	ADJ
admet-2753	424	15	digestion	digestion	NOUN
admet-2753	424	16	and	and	CCONJ
admet-2753	424	17	dialysis	dialysis	NOUN
admet-2753	424	18	of	of	ADP
admet-2753	424	19	apple	apple	NOUN
admet-2753	424	20	varieties	variety	NOUN
admet-2753	424	21	:	:	PUNCT
admet-2753	424	22	bioaccessibility	bioaccessibility	NOUN
admet-2753	424	23	and	and	CCONJ
admet-2753	424	24	potential	potential	ADJ
admet-2753	424	25	uptake	uptake	NOUN
admet-2753	424	26	.	.	PUNCT
admet-2753	425	1	food	food	NOUN
admet-2753	425	2	chemistry	chemistry	NOUN
admet-2753	425	3	128	128	NUM
admet-2753	425	4	(	(	PUNCT
admet-2753	425	5	2011	2011	NUM
admet-2753	425	6	)	)	PUNCT
admet-2753	425	7	14	14	NUM
admet-2753	425	8	-	-	SYM
admet-2753	425	9	21	21	NUM
admet-2753	425	10	.	.	PUNCT
admet-2753	426	1	https://doi.org/10.1016/j.foodchem.2011.02.052	https://doi.org/10.1016/j.foodchem.2011.02.052	PRON
admet-2753	427	1	[	[	X
admet-2753	427	2	19	19	NUM
admet-2753	427	3	]	]	X
admet-2753	427	4	s.a	s.a	PROPN
admet-2753	427	5	.	.	PROPN
admet-2753	427	6	raina	raina	PROPN
admet-2753	427	7	,	,	PUNCT
admet-2753	427	8	g.g	g.g	PROPN
admet-2753	427	9	.	.	PROPN
admet-2753	427	10	zhang	zhang	PROPN
admet-2753	427	11	,	,	PUNCT
admet-2753	427	12	d.e	d.e	PROPN
admet-2753	427	13	.	.	PROPN
admet-2753	427	14	alonzo	alonzo	PROPN
admet-2753	427	15	,	,	PUNCT
admet-2753	427	16	j.	j.	PROPN
admet-2753	427	17	wu	wu	PROPN
admet-2753	427	18	,	,	PUNCT
admet-2753	427	19	d.	d.	PROPN
admet-2753	427	20	zhu	zhu	PROPN
admet-2753	427	21	,	,	PUNCT
admet-2753	427	22	n.d	n.d	PROPN
admet-2753	427	23	.	.	PROPN
admet-2753	427	24	catron	catron	PROPN
admet-2753	427	25	,	,	PUNCT
admet-2753	427	26	y.	y.	PROPN
admet-2753	427	27	gao	gao	PROPN
admet-2753	427	28	,	,	PUNCT
admet-2753	427	29	l.s	l.s	PROPN
admet-2753	427	30	.	.	PROPN
admet-2753	427	31	taylor	taylor	PROPN
admet-2753	427	32	.	.	PUNCT
admet-2753	428	1	impact	impact	NOUN
admet-2753	428	2	of	of	ADP
admet-2753	428	3	solubilizing	solubilize	VERB
admet-2753	428	4	additives	additive	NOUN
admet-2753	428	5	on	on	ADP
admet-2753	428	6	supersaturation	supersaturation	NOUN
admet-2753	428	7	and	and	CCONJ
admet-2753	428	8	membrane	membrane	NOUN
admet-2753	428	9	transport	transport	NOUN
admet-2753	428	10	of	of	ADP
admet-2753	428	11	drugs	drug	NOUN
admet-2753	428	12	.	.	PUNCT
admet-2753	429	1	pharmaceutical	pharmaceutical	ADJ
admet-2753	429	2	research	research	NOUN
admet-2753	429	3	32	32	NUM
admet-2753	429	4	(	(	PUNCT
admet-2753	429	5	2015	2015	NUM
admet-2753	429	6	)	)	PUNCT
admet-2753	429	7	3350	3350	NUM
admet-2753	429	8	-	-	SYM
admet-2753	429	9	3364	3364	NUM
admet-2753	429	10	.	.	PUNCT
admet-2753	430	1	https://doi.org/10.1007/s11095-015-1712-4	https://doi.org/10.1007/s11095-015-1712-4	NUM
admet-2753	431	1	[	[	X
admet-2753	431	2	20	20	NUM
admet-2753	431	3	]	]	X
admet-2753	431	4	a.s	a.s	PROPN
admet-2753	431	5	.	.	PROPN
admet-2753	431	6	indulkar	indulkar	PROPN
admet-2753	431	7	,	,	PUNCT
admet-2753	431	8	y.	y.	PROPN
admet-2753	431	9	gao	gao	PROPN
admet-2753	431	10	,	,	PUNCT
admet-2753	431	11	s.a	s.a	PROPN
admet-2753	431	12	.	.	PROPN
admet-2753	431	13	raina	raina	PROPN
admet-2753	431	14	,	,	PUNCT
admet-2753	431	15	g.g	g.g	PROPN
admet-2753	431	16	.	.	PROPN
admet-2753	431	17	zhang	zhang	PROPN
admet-2753	431	18	,	,	PUNCT
admet-2753	431	19	l.s	l.s	PROPN
admet-2753	431	20	.	.	PROPN
admet-2753	431	21	taylor	taylor	PROPN
admet-2753	431	22	.	.	PUNCT
admet-2753	432	1	exploiting	exploit	VERB
admet-2753	432	2	the	the	DET
admet-2753	432	3	phenomenon	phenomenon	NOUN
admet-2753	432	4	of	of	ADP
admet-2753	432	5	liquid	liquid	NOUN
admet-2753	432	6	-	-	PUNCT
admet-2753	432	7	liquid	liquid	ADJ
admet-2753	432	8	phase	phase	NOUN
admet-2753	432	9	separation	separation	NOUN
admet-2753	432	10	for	for	ADP
admet-2753	432	11	enhanced	enhanced	ADJ
admet-2753	432	12	and	and	CCONJ
admet-2753	432	13	sustained	sustained	ADJ
admet-2753	432	14	membrane	membrane	NOUN
admet-2753	432	15	transport	transport	NOUN
admet-2753	432	16	of	of	ADP
admet-2753	432	17	a	a	DET
admet-2753	432	18	poorly	poorly	ADV
admet-2753	432	19	water	water	NOUN
admet-2753	432	20	-	-	PUNCT
admet-2753	432	21	soluble	soluble	ADJ
admet-2753	432	22	drug	drug	NOUN
admet-2753	432	23	.	.	PUNCT
admet-2753	433	1	molecular	molecular	ADJ
admet-2753	433	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	433	3	13	13	NUM
admet-2753	433	4	(	(	PUNCT
admet-2753	433	5	2016	2016	NUM
admet-2753	433	6	)	)	PUNCT
admet-2753	433	7	2059	2059	NUM
admet-2753	433	8	-	-	SYM
admet-2753	433	9	2069	2069	NUM
admet-2753	433	10	.	.	PUNCT
admet-2753	434	1	https://doi.org/10.1021/acs.molpharmaceut.6b00202	https://doi.org/10.1021/acs.molpharmaceut.6b00202	PROPN
admet-2753	435	1	[	[	X
admet-2753	435	2	21	21	NUM
admet-2753	435	3	]	]	X
admet-2753	435	4	j.p	j.p	PROPN
admet-2753	435	5	.	.	PROPN
admet-2753	435	6	o'shea	o'shea	PROPN
admet-2753	435	7	,	,	PUNCT
admet-2753	435	8	p.	p.	NOUN
admet-2753	435	9	augustijns	augustijns	NOUN
admet-2753	435	10	,	,	PUNCT
admet-2753	435	11	m.	m.	NOUN
admet-2753	435	12	brandl	brandl	PROPN
admet-2753	435	13	,	,	PUNCT
admet-2753	435	14	d.j	d.j	PROPN
admet-2753	435	15	.	.	PROPN
admet-2753	435	16	brayden	brayden	PROPN
admet-2753	435	17	,	,	PUNCT
admet-2753	435	18	j.	j.	PROPN
admet-2753	435	19	brouwers	brouwers	PROPN
admet-2753	435	20	,	,	PUNCT
admet-2753	435	21	b.t	b.t	PROPN
admet-2753	435	22	.	.	PROPN
admet-2753	435	23	griffin	griffin	PROPN
admet-2753	435	24	,	,	PUNCT
admet-2753	435	25	r.	r.	PROPN
admet-2753	435	26	holm	holm	PROPN
admet-2753	435	27	,	,	PUNCT
admet-2753	435	28	a.c	a.c	PROPN
admet-2753	435	29	.	.	PROPN
admet-2753	435	30	jacobsen	jacobsen	PROPN
admet-2753	435	31	,	,	PUNCT
admet-2753	435	32	h.	h.	PROPN
admet-2753	435	33	lennernäs	lennernäs	PROPN
admet-2753	435	34	,	,	PUNCT
admet-2753	435	35	z.	z.	PROPN
admet-2753	435	36	vinarov	vinarov	PROPN
admet-2753	435	37	,	,	PUNCT
admet-2753	435	38	c.m	c.m	PROPN
admet-2753	435	39	.	.	PROPN
admet-2753	435	40	o'driscoll	o'driscoll	PROPN
admet-2753	435	41	.	.	PUNCT
admet-2753	436	1	best	good	ADJ
admet-2753	436	2	practices	practice	NOUN
admet-2753	436	3	in	in	ADP
admet-2753	436	4	current	current	ADJ
admet-2753	436	5	models	model	NOUN
admet-2753	436	6	mimicking	mimic	VERB
admet-2753	436	7	drug	drug	NOUN
admet-2753	436	8	permeability	permeability	NOUN
admet-2753	436	9	in	in	ADP
admet-2753	436	10	the	the	DET
admet-2753	436	11	gastrointestinal	gastrointestinal	ADJ
admet-2753	436	12	tract	tract	NOUN
admet-2753	436	13	an	an	DET
admet-2753	436	14	ungap	ungap	NOUN
admet-2753	436	15	review	review	NOUN
admet-2753	436	16	.	.	PUNCT
admet-2753	437	1	european	european	PROPN
admet-2753	437	2	journal	journal	PROPN
admet-2753	437	3	of	of	ADP
admet-2753	437	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	437	5	sciences	science	NOUN
admet-2753	437	6	170	170	NUM
admet-2753	437	7	(	(	PUNCT
admet-2753	437	8	2022	2022	NUM
admet-2753	437	9	)	)	PUNCT
admet-2753	437	10	106098	106098	NUM
admet-2753	437	11	.	.	PUNCT
admet-2753	438	1	https://doi.org/10.1016/j.ejps.2021.106098	https://doi.org/10.1016/j.ejps.2021.106098	PROPN
admet-2753	438	2	[	[	X
admet-2753	438	3	22	22	NUM
admet-2753	438	4	]	]	X
admet-2753	438	5	e.	e.	PROPN
admet-2753	438	6	borbás	borbás	PROPN
admet-2753	438	7	,	,	PUNCT
admet-2753	438	8	p.	p.	PROPN
admet-2753	438	9	tőzsér	tőzsér	PROPN
admet-2753	438	10	,	,	PUNCT
admet-2753	438	11	k.	k.	PROPN
admet-2753	438	12	tsinman	tsinman	PROPN
admet-2753	438	13	,	,	PUNCT
admet-2753	438	14	o.	o.	PROPN
admet-2753	438	15	tsinman	tsinman	PROPN
admet-2753	438	16	,	,	PUNCT
admet-2753	438	17	k.	k.	PROPN
admet-2753	438	18	takács	takács	PROPN
admet-2753	438	19	-	-	PUNCT
admet-2753	438	20	novák	novák	PROPN
admet-2753	438	21	,	,	PUNCT
admet-2753	438	22	g.	g.	PROPN
admet-2753	438	23	völgyi	völgyi	PROPN
admet-2753	438	24	,	,	PUNCT
admet-2753	438	25	b.	b.	PROPN
admet-2753	438	26	sinkó	sinkó	PROPN
admet-2753	438	27	,	,	PUNCT
admet-2753	438	28	z.k	z.k	PROPN
admet-2753	438	29	.	.	PROPN
admet-2753	438	30	nagy	nagy	PROPN
admet-2753	438	31	.	.	PUNCT
admet-2753	439	1	effect	effect	NOUN
admet-2753	439	2	of	of	ADP
admet-2753	439	3	formulation	formulation	NOUN
admet-2753	439	4	additives	additive	NOUN
admet-2753	439	5	on	on	ADP
admet-2753	439	6	drug	drug	NOUN
admet-2753	439	7	transport	transport	NOUN
admet-2753	439	8	through	through	ADP
admet-2753	439	9	size	size	NOUN
admet-2753	439	10	-	-	PUNCT
admet-2753	439	11	exclusion	exclusion	NOUN
admet-2753	439	12	membranes	membrane	NOUN
admet-2753	439	13	.	.	PUNCT
admet-2753	440	1	molecular	molecular	ADJ
admet-2753	440	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	440	3	15	15	NUM
admet-2753	440	4	(	(	PUNCT
admet-2753	440	5	2018	2018	NUM
admet-2753	440	6	)	)	PUNCT
admet-2753	440	7	3308	3308	NUM
admet-2753	440	8	-	-	SYM
admet-2753	440	9	3317	3317	NUM
admet-2753	440	10	.	.	PUNCT
admet-2753	441	1	https://doi.org/10.1021/acs.molpharmaceut.8b00343	https://doi.org/10.1021/acs.molpharmaceut.8b00343	NOUN
admet-2753	442	1	[	[	X
admet-2753	442	2	23	23	NUM
admet-2753	442	3	]	]	PUNCT
admet-2753	442	4	p.	p.	PROPN
admet-2753	442	5	berben	berben	PROPN
admet-2753	442	6	,	,	PUNCT
admet-2753	442	7	j.	j.	PROPN
admet-2753	442	8	brouwers	brouwers	PROPN
admet-2753	442	9	,	,	PUNCT
admet-2753	442	10	p.	p.	NOUN
admet-2753	442	11	augustijns	augustijns	NOUN
admet-2753	442	12	.	.	PUNCT
admet-2753	443	1	the	the	DET
admet-2753	443	2	artificial	artificial	ADJ
admet-2753	443	3	membrane	membrane	NOUN
admet-2753	443	4	insert	insert	NOUN
admet-2753	443	5	system	system	NOUN
admet-2753	443	6	as	as	ADP
admet-2753	443	7	predictive	predictive	ADJ
admet-2753	443	8	tool	tool	NOUN
admet-2753	443	9	for	for	ADP
admet-2753	443	10	formulation	formulation	NOUN
admet-2753	443	11	performance	performance	NOUN
admet-2753	443	12	evaluation	evaluation	NOUN
admet-2753	443	13	.	.	PUNCT
admet-2753	444	1	international	international	ADJ
admet-2753	444	2	journal	journal	PROPN
admet-2753	444	3	of	of	ADP
admet-2753	444	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	444	5	537	537	NUM
admet-2753	444	6	(	(	PUNCT
admet-2753	444	7	2018	2018	NUM
admet-2753	444	8	)	)	PUNCT
admet-2753	444	9	22	22	NUM
admet-2753	444	10	-	-	SYM
admet-2753	444	11	29	29	NUM
admet-2753	444	12	.	.	PUNCT
admet-2753	445	1	https://doi.org/https://doi.org/10.1016/j.ijpharm.2017.12.025	https://doi.org/https://doi.org/10.1016/j.ijpharm.2017.12.025	NOUN
admet-2753	446	1	[	[	X
admet-2753	446	2	24	24	NUM
admet-2753	446	3	]	]	X
admet-2753	446	4	p.	p.	PROPN
admet-2753	446	5	berben	berben	PROPN
admet-2753	446	6	,	,	PUNCT
admet-2753	446	7	j.	j.	PROPN
admet-2753	446	8	brouwers	brouwers	PROPN
admet-2753	446	9	,	,	PUNCT
admet-2753	446	10	p.	p.	NOUN
admet-2753	446	11	augustijns	augustijns	NOUN
admet-2753	446	12	.	.	PUNCT
admet-2753	447	1	assessment	assessment	NOUN
admet-2753	447	2	of	of	ADP
admet-2753	447	3	passive	passive	ADJ
admet-2753	447	4	intestinal	intestinal	ADJ
admet-2753	447	5	permeability	permeability	NOUN
admet-2753	447	6	using	use	VERB
admet-2753	447	7	an	an	DET
admet-2753	447	8	artificial	artificial	ADJ
admet-2753	447	9	membrane	membrane	NOUN
admet-2753	447	10	insert	insert	NOUN
admet-2753	447	11	system	system	NOUN
admet-2753	447	12	.	.	PUNCT
admet-2753	448	1	journal	journal	PROPN
admet-2753	448	2	of	of	ADP
admet-2753	448	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	448	4	sciences	science	NOUN
admet-2753	448	5	107	107	NUM
admet-2753	448	6	(	(	PUNCT
admet-2753	448	7	2018	2018	NUM
admet-2753	448	8	)	)	PUNCT
admet-2753	448	9	250	250	NUM
admet-2753	448	10	-	-	SYM
admet-2753	448	11	256	256	NUM
admet-2753	448	12	.	.	PUNCT
admet-2753	449	1	https://doi.org/10.1016/j.xphs.2017.08.002	https://doi.org/10.1016/j.xphs.2017.08.002	NOUN
admet-2753	449	2	[	[	X
admet-2753	449	3	25	25	NUM
admet-2753	449	4	]	]	PUNCT
admet-2753	449	5	k.	k.	PROPN
admet-2753	449	6	sakai	sakai	PROPN
admet-2753	449	7	.	.	PUNCT
admet-2753	450	1	determination	determination	NOUN
admet-2753	450	2	of	of	ADP
admet-2753	450	3	pore	pore	ADJ
admet-2753	450	4	size	size	NOUN
admet-2753	450	5	and	and	CCONJ
admet-2753	450	6	pore	pore	ADJ
admet-2753	450	7	size	size	NOUN
admet-2753	450	8	distribution	distribution	NOUN
admet-2753	450	9	:	:	PUNCT
admet-2753	450	10	2	2	NUM
admet-2753	450	11	.	.	X
admet-2753	450	12	dialysis	dialysis	NOUN
admet-2753	450	13	membranes	membrane	NOUN
admet-2753	450	14	.	.	PUNCT
admet-2753	451	1	journal	journal	NOUN
admet-2753	451	2	of	of	ADP
admet-2753	451	3	membrane	membrane	NOUN
admet-2753	451	4	science	science	NOUN
admet-2753	451	5	96	96	NUM
admet-2753	451	6	(	(	PUNCT
admet-2753	451	7	1994	1994	NUM
admet-2753	451	8	)	)	PUNCT
admet-2753	451	9	91	91	NUM
admet-2753	451	10	-	-	SYM
admet-2753	451	11	130	130	NUM
admet-2753	451	12	.	.	PUNCT
admet-2753	452	1	https://doi.org/https://doi.org/10.1016/0376-7388(94)00127-8	https://doi.org/https://doi.org/10.1016/0376-7388(94)00127-8	PROPN
admet-2753	452	2	[	[	X
admet-2753	452	3	26	26	NUM
admet-2753	452	4	]	]	PUNCT
admet-2753	452	5	a.	a.	NOUN
admet-2753	452	6	dahan	dahan	PROPN
admet-2753	452	7	,	,	PUNCT
admet-2753	452	8	a.	a.	PROPN
admet-2753	452	9	beig	beig	PROPN
admet-2753	452	10	,	,	PUNCT
admet-2753	452	11	d.	d.	PROPN
admet-2753	452	12	lindley	lindley	PROPN
admet-2753	452	13	,	,	PUNCT
admet-2753	452	14	j.m	j.m	PROPN
admet-2753	452	15	.	.	PROPN
admet-2753	452	16	miller	miller	PROPN
admet-2753	452	17	.	.	PUNCT
admet-2753	453	1	the	the	DET
admet-2753	453	2	solubility	solubility	NOUN
admet-2753	453	3	-	-	PUNCT
admet-2753	453	4	permeability	permeability	NOUN
admet-2753	453	5	interplay	interplay	NOUN
admet-2753	453	6	and	and	CCONJ
admet-2753	453	7	oral	oral	ADJ
admet-2753	453	8	drug	drug	NOUN
admet-2753	453	9	formulation	formulation	NOUN
admet-2753	453	10	design	design	NOUN
admet-2753	453	11	:	:	PUNCT
admet-2753	453	12	two	two	NUM
admet-2753	453	13	heads	head	NOUN
admet-2753	453	14	are	be	AUX
admet-2753	453	15	better	well	ADJ
admet-2753	453	16	than	than	ADP
admet-2753	453	17	one	one	NUM
admet-2753	453	18	.	.	PUNCT
admet-2753	454	1	advanced	advanced	ADJ
admet-2753	454	2	drug	drug	NOUN
admet-2753	454	3	delivery	delivery	NOUN
admet-2753	454	4	reviews	review	VERB
admet-2753	454	5	101	101	NUM
admet-2753	454	6	(	(	PUNCT
admet-2753	454	7	2016	2016	NUM
admet-2753	454	8	)	)	PUNCT
admet-2753	454	9	99107	99107	NUM
admet-2753	454	10	.	.	PUNCT
admet-2753	455	1	https://doi.org/10.1016/j.addr.2016.04.018	https://doi.org/10.1016/j.addr.2016.04.018	NOUN
admet-2753	456	1	[	[	X
admet-2753	456	2	27	27	NUM
admet-2753	456	3	]	]	X
admet-2753	456	4	s.	s.	PROPN
admet-2753	456	5	kádár	kádár	PROPN
admet-2753	456	6	,	,	PUNCT
admet-2753	456	7	p.	p.	PROPN
admet-2753	456	8	tőzsér	tőzsér	PROPN
admet-2753	456	9	,	,	PUNCT
admet-2753	456	10	b.	b.	PROPN
admet-2753	456	11	nagy	nagy	PROPN
admet-2753	456	12	,	,	PUNCT
admet-2753	456	13	a.	a.	PROPN
admet-2753	456	14	farkas	farkas	PROPN
admet-2753	456	15	,	,	PUNCT
admet-2753	456	16	z.k	z.k	PROPN
admet-2753	456	17	.	.	PROPN
admet-2753	456	18	nagy	nagy	PROPN
admet-2753	456	19	,	,	PUNCT
admet-2753	456	20	o.	o.	PROPN
admet-2753	456	21	tsinman	tsinman	PROPN
admet-2753	456	22	,	,	PUNCT
admet-2753	456	23	k.	k.	PROPN
admet-2753	456	24	tsinman	tsinman	PROPN
admet-2753	456	25	,	,	PUNCT
admet-2753	456	26	d.	d.	PROPN
admet-2753	456	27	csicsák	csicsák	PROPN
admet-2753	456	28	,	,	PUNCT
admet-2753	456	29	g.	g.	PROPN
admet-2753	456	30	völgyi	völgyi	PROPN
admet-2753	456	31	,	,	PUNCT
admet-2753	456	32	k.	k.	PROPN
admet-2753	456	33	takács	takács	PROPN
admet-2753	456	34	-	-	PUNCT
admet-2753	456	35	novák	novák	PROPN
admet-2753	456	36	,	,	PUNCT
admet-2753	456	37	e.	e.	PROPN
admet-2753	456	38	borbás	borbás	PROPN
admet-2753	456	39	,	,	PUNCT
admet-2753	456	40	b.	b.	PROPN
admet-2753	456	41	sinkó	sinkó	PROPN
admet-2753	456	42	.	.	PUNCT
admet-2753	456	43	flux	flux	NOUN
admet-2753	456	44	-	-	PUNCT
admet-2753	456	45	based	base	VERB
admet-2753	456	46	formulation	formulation	NOUN
admet-2753	456	47	development	development	NOUN
admet-2753	456	48	-	-	PUNCT
admet-2753	456	49	a	a	DET
admet-2753	456	50	proof	proof	NOUN
admet-2753	456	51	of	of	ADP
admet-2753	456	52	concept	concept	NOUN
admet-2753	456	53	study	study	NOUN
admet-2753	456	54	.	.	PUNCT
admet-2753	457	1	the	the	DET
admet-2753	457	2	aaps	aaps	PROPN
admet-2753	457	3	journal	journal	PROPN
admet-2753	457	4	24	24	NUM
admet-2753	457	5	(	(	PUNCT
admet-2753	457	6	2022	2022	NUM
admet-2753	457	7	)	)	PUNCT
admet-2753	457	8	22	22	NUM
admet-2753	457	9	.	.	PUNCT
admet-2753	458	1	https://doi.org/10.1208/s12248-021-00668-9	https://doi.org/10.1208/s12248-021-00668-9	PRON
admet-2753	459	1	[	[	X
admet-2753	459	2	28	28	NUM
admet-2753	459	3	]	]	X
admet-2753	459	4	a.	a.	NOUN
admet-2753	459	5	de	de	X
admet-2753	459	6	simone	simone	PROPN
admet-2753	459	7	,	,	PUNCT
admet-2753	459	8	l.	l.	PROPN
admet-2753	459	9	davani	davani	PROPN
admet-2753	459	10	,	,	PUNCT
admet-2753	459	11	s.	s.	PROPN
admet-2753	459	12	montanari	montanari	PROPN
admet-2753	459	13	,	,	PUNCT
admet-2753	459	14	v.	v.	PROPN
admet-2753	459	15	tumiatti	tumiatti	PROPN
admet-2753	459	16	,	,	PUNCT
admet-2753	459	17	s.	s.	PROPN
admet-2753	459	18	avanessian	avanessian	PROPN
admet-2753	459	19	,	,	PUNCT
admet-2753	459	20	f.	f.	PROPN
admet-2753	459	21	testi	testi	PROPN
admet-2753	459	22	,	,	PUNCT
admet-2753	459	23	v.	v.	CCONJ
admet-2753	459	24	andrisano	andrisano	X
admet-2753	459	25	.	.	PUNCT
admet-2753	460	1	combined	combine	VERB
admet-2753	460	2	methodologies	methodology	NOUN
admet-2753	460	3	for	for	ADP
admet-2753	460	4	determining	determine	VERB
admet-2753	460	5	in	in	ADP
admet-2753	460	6	vitro	vitro	X
admet-2753	460	7	bioavailability	bioavailability	NOUN
admet-2753	460	8	of	of	ADP
admet-2753	460	9	drugs	drug	NOUN
admet-2753	460	10	and	and	CCONJ
admet-2753	460	11	prediction	prediction	NOUN
admet-2753	460	12	of	of	ADP
admet-2753	460	13	in	in	ADP
admet-2753	460	14	vivo	vivo	ADJ
admet-2753	460	15	bioequivalence	bioequivalence	NOUN
admet-2753	460	16	from	from	ADP
admet-2753	460	17	pharmaceutical	pharmaceutical	ADJ
admet-2753	460	18	oral	oral	ADJ
admet-2753	460	19	formulations	formulation	NOUN
admet-2753	460	20	.	.	PUNCT
admet-2753	461	1	frontiers	frontier	NOUN
admet-2753	461	2	in	in	ADP
admet-2753	461	3	chemistry	chemistry	NOUN
admet-2753	461	4	9	9	NUM
admet-2753	461	5	(	(	PUNCT
admet-2753	461	6	2021	2021	NUM
admet-2753	461	7	)	)	PUNCT
admet-2753	461	8	741876	741876	NUM
admet-2753	461	9	.	.	PUNCT
admet-2753	462	1	https://doi.org/10.3389/fchem.2021.741876	https://doi.org/10.3389/fchem.2021.741876	PROPN
admet-2753	463	1	[	[	X
admet-2753	463	2	29	29	NUM
admet-2753	463	3	]	]	X
admet-2753	463	4	a.	a.	NOUN
admet-2753	463	5	beig	beig	PROPN
admet-2753	463	6	,	,	PUNCT
admet-2753	463	7	j.m	j.m	PROPN
admet-2753	463	8	.	.	PROPN
admet-2753	463	9	miller	miller	PROPN
admet-2753	463	10	,	,	PUNCT
admet-2753	463	11	d.	d.	PROPN
admet-2753	463	12	lindley	lindley	PROPN
admet-2753	463	13	,	,	PUNCT
admet-2753	463	14	r.a	r.a	PROPN
admet-2753	463	15	.	.	PROPN
admet-2753	463	16	carr	carr	PROPN
admet-2753	463	17	,	,	PUNCT
admet-2753	463	18	p.	p.	PROPN
admet-2753	463	19	zocharski	zocharski	PROPN
admet-2753	463	20	,	,	PUNCT
admet-2753	463	21	r.	r.	PROPN
admet-2753	463	22	agbaria	agbaria	PROPN
admet-2753	463	23	,	,	PUNCT
admet-2753	463	24	a.	a.	PROPN
admet-2753	463	25	dahan	dahan	PROPN
admet-2753	463	26	.	.	PUNCT
admet-2753	464	1	head	head	PROPN
admet-2753	464	2	-	-	PUNCT
admet-2753	464	3	to	to	ADP
admet-2753	464	4	-	-	PUNCT
admet-2753	464	5	head	head	NOUN
admet-2753	464	6	comparison	comparison	NOUN
admet-2753	464	7	of	of	ADP
admet-2753	464	8	different	different	ADJ
admet-2753	464	9	solubility	solubility	NOUN
admet-2753	464	10	-	-	PUNCT
admet-2753	464	11	enabling	enable	VERB
admet-2753	464	12	formulations	formulation	NOUN
admet-2753	464	13	of	of	ADP
admet-2753	464	14	etoposide	etoposide	NOUN
admet-2753	464	15	and	and	CCONJ
admet-2753	464	16	their	their	PRON
admet-2753	464	17	consequent	consequent	ADJ
admet-2753	464	18	solubility	solubility	NOUN
admet-2753	464	19	-	-	PUNCT
admet-2753	464	20	permeability	permeability	NOUN
admet-2753	464	21	interplay	interplay	NOUN
admet-2753	464	22	.	.	PUNCT
admet-2753	465	1	journal	journal	NOUN
admet-2753	465	2	of	of	ADP
admet-2753	465	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	465	4	sciences	science	NOUN
admet-2753	465	5	104	104	NUM
admet-2753	465	6	(	(	PUNCT
admet-2753	465	7	2015	2015	NUM
admet-2753	465	8	)	)	PUNCT
admet-2753	465	9	2941	2941	NUM
admet-2753	465	10	-	-	SYM
admet-2753	465	11	2947	2947	NUM
admet-2753	465	12	.	.	PUNCT
admet-2753	466	1	https://doi.org/10.1002/jps.24496	https://doi.org/10.1002/jps.24496	NOUN
admet-2753	467	1	[	[	X
admet-2753	467	2	30	30	NUM
admet-2753	467	3	]	]	X
admet-2753	467	4	m.	m.	NOUN
admet-2753	467	5	van	van	PROPN
admet-2753	467	6	der	der	PROPN
admet-2753	467	7	veken	veken	PROPN
admet-2753	467	8	,	,	PUNCT
admet-2753	467	9	j.	j.	PROPN
admet-2753	467	10	brouwers	brouwers	PROPN
admet-2753	467	11	,	,	PUNCT
admet-2753	467	12	n.	n.	PROPN
admet-2753	467	13	parrott	parrott	PROPN
admet-2753	467	14	,	,	PUNCT
admet-2753	467	15	p.	p.	NOUN
admet-2753	467	16	augustijns	augustijns	NOUN
admet-2753	467	17	,	,	PUNCT
admet-2753	467	18	c.	c.	PROPN
admet-2753	467	19	stillhart	stillhart	PROPN
admet-2753	467	20	.	.	PUNCT
admet-2753	468	1	investigating	investigate	VERB
admet-2753	468	2	the	the	DET
admet-2753	468	3	effect	effect	NOUN
admet-2753	468	4	of	of	ADP
admet-2753	468	5	whey	whey	PROPN
admet-2753	468	6	and	and	CCONJ
admet-2753	468	7	casein	casein	NOUN
admet-2753	468	8	proteins	protein	NOUN
admet-2753	468	9	on	on	ADP
admet-2753	468	10	drug	drug	NOUN
admet-2753	468	11	solubility	solubility	NOUN
admet-2753	468	12	from	from	ADP
admet-2753	468	13	a	a	DET
admet-2753	468	14	paediatric	paediatric	ADJ
admet-2753	468	15	drug	drug	NOUN
admet-2753	468	16	absorption	absorption	NOUN
admet-2753	468	17	perspective	perspective	NOUN
admet-2753	468	18	.	.	PUNCT
admet-2753	469	1	international	international	ADJ
admet-2753	469	2	journal	journal	PROPN
admet-2753	469	3	of	of	ADP
admet-2753	469	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	469	5	:	:	PUNCT
admet-2753	469	6	x	x	SYM
admet-2753	469	7	8	8	NUM
admet-2753	469	8	(	(	PUNCT
admet-2753	469	9	2024	2024	NUM
admet-2753	469	10	)	)	PUNCT
admet-2753	469	11	100290	100290	NUM
admet-2753	469	12	.	.	PUNCT
admet-2753	470	1	https://doi.org/10.1016/j.ijpx.2024.100290	https://doi.org/10.1016/j.ijpx.2024.100290	PROPN
admet-2753	471	1	[	[	X
admet-2753	471	2	31	31	NUM
admet-2753	471	3	]	]	PUNCT
admet-2753	471	4	k.	k.	PROPN
admet-2753	471	5	ueda	ueda	PROPN
admet-2753	471	6	,	,	PUNCT
admet-2753	471	7	l.s	l.s	PROPN
admet-2753	471	8	.	.	PROPN
admet-2753	471	9	taylor	taylor	PROPN
admet-2753	471	10	.	.	PUNCT
admet-2753	472	1	partitioning	partition	VERB
admet-2753	472	2	of	of	ADP
admet-2753	472	3	surfactant	surfactant	NOUN
admet-2753	472	4	into	into	ADP
admet-2753	472	5	drug	drug	NOUN
admet-2753	472	6	-	-	PUNCT
admet-2753	472	7	rich	rich	ADJ
admet-2753	472	8	nanodroplets	nanodroplet	NOUN
admet-2753	472	9	and	and	CCONJ
admet-2753	472	10	its	its	PRON
admet-2753	472	11	impact	impact	NOUN
admet-2753	472	12	on	on	ADP
admet-2753	472	13	drug	drug	NOUN
admet-2753	472	14	thermodynamic	thermodynamic	ADJ
admet-2753	472	15	activity	activity	NOUN
admet-2753	472	16	and	and	CCONJ
admet-2753	472	17	droplet	droplet	ADJ
admet-2753	472	18	size	size	NOUN
admet-2753	472	19	.	.	PUNCT
admet-2753	473	1	journal	journal	PROPN
admet-2753	473	2	of	of	ADP
admet-2753	473	3	controlled	control	VERB
admet-2753	473	4	release	release	NOUN
admet-2753	473	5	330	330	NUM
admet-2753	473	6	(	(	PUNCT
admet-2753	473	7	2021	2021	NUM
admet-2753	473	8	)	)	PUNCT
admet-2753	473	9	229	229	NUM
admet-2753	473	10	-	-	SYM
admet-2753	473	11	243	243	NUM
admet-2753	473	12	.	.	PUNCT
admet-2753	474	1	https://doi.org/10.1016/j.jconrel.2020.12.018	https://doi.org/10.1016/j.jconrel.2020.12.018	NOUN
admet-2753	474	2	[	[	X
admet-2753	474	3	32	32	NUM
admet-2753	474	4	]	]	X
admet-2753	474	5	m.j	m.j	PROPN
admet-2753	474	6	.	.	PROPN
admet-2753	474	7	jackson	jackson	PROPN
admet-2753	474	8	,	,	PUNCT
admet-2753	474	9	u.s	u.s	PROPN
admet-2753	474	10	.	.	PROPN
admet-2753	474	11	kestur	kestur	PROPN
admet-2753	474	12	,	,	PUNCT
admet-2753	474	13	m.a	m.a	PROPN
admet-2753	474	14	.	.	PROPN
admet-2753	474	15	hussain	hussain	PROPN
admet-2753	474	16	,	,	PUNCT
admet-2753	474	17	l.s	l.s	PROPN
admet-2753	474	18	.	.	PROPN
admet-2753	474	19	taylor	taylor	PROPN
admet-2753	474	20	.	.	PUNCT
admet-2753	475	1	dissolution	dissolution	PROPN
admet-2753	475	2	of	of	ADP
admet-2753	475	3	danazol	danazol	ADJ
admet-2753	475	4	amorphous	amorphous	ADJ
admet-2753	475	5	solid	solid	ADJ
admet-2753	475	6	dispersions	dispersion	NOUN
admet-2753	475	7	:	:	PUNCT
admet-2753	475	8	supersaturation	supersaturation	NOUN
admet-2753	475	9	and	and	CCONJ
admet-2753	475	10	phase	phase	NOUN
admet-2753	475	11	behavior	behavior	NOUN
admet-2753	475	12	as	as	ADP
admet-2753	475	13	a	a	DET
admet-2753	475	14	function	function	NOUN
admet-2753	475	15	of	of	ADP
admet-2753	475	16	drug	drug	NOUN
admet-2753	475	17	loading	loading	NOUN
admet-2753	475	18	and	and	CCONJ
admet-2753	475	19	polymer	polymer	NOUN
admet-2753	475	20	type	type	NOUN
admet-2753	475	21	.	.	PUNCT
admet-2753	476	1	molecular	molecular	ADJ
admet-2753	476	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	476	3	13	13	NUM
admet-2753	476	4	(	(	PUNCT
admet-2753	476	5	2016	2016	NUM
admet-2753	476	6	)	)	PUNCT
admet-2753	476	7	223	223	NUM
admet-2753	476	8	-	-	SYM
admet-2753	476	9	231	231	NUM
admet-2753	476	10	.	.	PUNCT
admet-2753	477	1	https://doi.org/10.1021/acs.molpharmaceut.5b00652	https://doi.org/10.1021/acs.molpharmaceut.5b00652	X
admet-2753	477	2	https://doi.org/10.1016/j.ijpharm.2016.03.049	https://doi.org/10.1016/j.ijpharm.2016.03.049	PROPN
admet-2753	477	3	https://doi.org/10.1016/j.foodchem.2011.02.052	https://doi.org/10.1016/j.foodchem.2011.02.052	NUM
admet-2753	477	4	https://doi.org/10.1007/s11095-015-1712-4	https://doi.org/10.1007/s11095-015-1712-4	NUM
admet-2753	477	5	https://doi.org/10.1021/acs.molpharmaceut.6b00202	https://doi.org/10.1021/acs.molpharmaceut.6b00202	PRON
admet-2753	477	6	https://doi.org/10.1016/j.ejps.2021.106098	https://doi.org/10.1016/j.ejps.2021.106098	PROPN
admet-2753	477	7	https://doi.org/10.1021/acs.molpharmaceut.8b00343	https://doi.org/10.1021/acs.molpharmaceut.8b00343	NOUN
admet-2753	477	8	https://doi.org/https:/doi.org/10.1016/j.ijpharm.2017.12.025	https://doi.org/https:/doi.org/10.1016/j.ijpharm.2017.12.025	ADJ
admet-2753	477	9	https://doi.org/10.1016/j.xphs.2017.08.002	https://doi.org/10.1016/j.xphs.2017.08.002	NOUN
admet-2753	477	10	https://doi.org/https:/doi.org/10.1016/0376-7388(94)00127-8	https://doi.org/https:/doi.org/10.1016/0376-7388(94)00127-8	PROPN
admet-2753	477	11	https://doi.org/10.1016/j.addr.2016.04.018	https://doi.org/10.1016/j.addr.2016.04.018	VERB
admet-2753	477	12	https://doi.org/10.1208/s12248-021-00668-9	https://doi.org/10.1208/s12248-021-00668-9	NUM
admet-2753	477	13	https://doi.org/10.3389/fchem.2021.741876	https://doi.org/10.3389/fchem.2021.741876	PROPN
admet-2753	478	1	https://doi.org/10.1002/jps.24496	https://doi.org/10.1002/jps.24496	PROPN
admet-2753	478	2	https://doi.org/10.1016/j.ijpx.2024.100290	https://doi.org/10.1016/j.ijpx.2024.100290	PROPN
admet-2753	478	3	https://doi.org/10.1016/j.jconrel.2020.12.018	https://doi.org/10.1016/j.jconrel.2020.12.018	VERB
admet-2753	478	4	https://doi.org/10.1021/acs.molpharmaceut.5b00652	https://doi.org/10.1021/acs.molpharmaceut.5b00652	PROPN
admet-2753	478	5	admet	admet	PROPN
admet-2753	478	6	&	&	CCONJ
admet-2753	478	7	dmpk	dmpk	PROPN
admet-2753	478	8	13(4	13(4	NUM
admet-2753	478	9	)	)	PUNCT
admet-2753	478	10	(	(	PUNCT
admet-2753	478	11	2025	2025	NUM
admet-2753	478	12	)	)	PUNCT
admet-2753	478	13	2753	2753	NUM
admet-2753	478	14	comparison	comparison	NOUN
admet-2753	478	15	of	of	ADP
admet-2753	478	16	lipophilic	lipophilic	ADJ
admet-2753	478	17	and	and	CCONJ
admet-2753	478	18	size	size	NOUN
admet-2753	478	19	-	-	PUNCT
admet-2753	478	20	exclusion	exclusion	NOUN
admet-2753	478	21	membranes	membrane	NOUN
admet-2753	478	22	doi	doi	NOUN
admet-2753	478	23	:	:	PUNCT
admet-2753	478	24	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	X
admet-2753	478	25	21	21	NUM
admet-2753	479	1	[	[	SYM
admet-2753	479	2	33	33	NUM
admet-2753	479	3	]	]	PUNCT
admet-2753	479	4	t.	t.	PROPN
admet-2753	479	5	loftsson	loftsson	PROPN
admet-2753	479	6	,	,	PUNCT
admet-2753	479	7	s.b	s.b	PROPN
admet-2753	479	8	.	.	PROPN
admet-2753	479	9	vogensen	vogensen	PROPN
admet-2753	479	10	,	,	PUNCT
admet-2753	479	11	c.	c.	PROPN
admet-2753	479	12	desbos	desbos	PROPN
admet-2753	479	13	,	,	PUNCT
admet-2753	479	14	p.	p.	NOUN
admet-2753	479	15	jansook	jansook	PROPN
admet-2753	479	16	.	.	PUNCT
admet-2753	480	1	carvedilol	carvedilol	NOUN
admet-2753	480	2	:	:	PUNCT
admet-2753	480	3	solubilization	solubilization	NOUN
admet-2753	480	4	and	and	CCONJ
admet-2753	480	5	cyclodextrin	cyclodextrin	NOUN
admet-2753	480	6	complexation	complexation	NOUN
admet-2753	480	7	:	:	PUNCT
admet-2753	480	8	a	a	DET
admet-2753	480	9	technical	technical	ADJ
admet-2753	480	10	note	note	NOUN
admet-2753	480	11	.	.	PUNCT
admet-2753	481	1	aaps	aap	NOUN
admet-2753	481	2	pharmscitech	pharmscitech	VERB
admet-2753	481	3	9	9	NUM
admet-2753	481	4	(	(	PUNCT
admet-2753	481	5	2008	2008	NUM
admet-2753	481	6	)	)	PUNCT
admet-2753	481	7	425	425	NUM
admet-2753	481	8	-	-	SYM
admet-2753	481	9	430	430	NUM
admet-2753	481	10	.	.	PUNCT
admet-2753	482	1	https://doi.org/10.1208/s12249-008-9055-7	https://doi.org/10.1208/s12249-008-9055-7	NUM
admet-2753	483	1	[	[	X
admet-2753	483	2	34	34	NUM
admet-2753	483	3	]	]	PUNCT
admet-2753	483	4	t.	t.	PROPN
admet-2753	483	5	loftsson	loftsson	NOUN
admet-2753	483	6	.	.	PUNCT
admet-2753	484	1	cyclodextrins	cyclodextrin	NOUN
admet-2753	484	2	in	in	ADP
admet-2753	484	3	parenteral	parenteral	ADJ
admet-2753	484	4	formulations	formulation	NOUN
admet-2753	484	5	.	.	PUNCT
admet-2753	485	1	journal	journal	PROPN
admet-2753	485	2	of	of	ADP
admet-2753	485	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	485	4	sciences	science	NOUN
admet-2753	485	5	110	110	NUM
admet-2753	485	6	(	(	PUNCT
admet-2753	485	7	2021	2021	NUM
admet-2753	485	8	)	)	PUNCT
admet-2753	485	9	654	654	NUM
admet-2753	485	10	-	-	PUNCT
admet-2753	485	11	664	664	NUM
admet-2753	485	12	.	.	PUNCT
admet-2753	486	1	https://doi.org/10.1016/j.xphs.2020.10.026	https://doi.org/10.1016/j.xphs.2020.10.026	PROPN
admet-2753	487	1	[	[	X
admet-2753	487	2	35	35	NUM
admet-2753	487	3	]	]	X
admet-2753	487	4	s.	s.	PROPN
admet-2753	487	5	sripetch	sripetch	PROPN
admet-2753	487	6	,	,	PUNCT
admet-2753	487	7	m.	m.	PROPN
admet-2753	487	8	prajapati	prajapati	PROPN
admet-2753	487	9	,	,	PUNCT
admet-2753	487	10	t.	t.	PROPN
admet-2753	487	11	loftsson	loftsson	NOUN
admet-2753	487	12	.	.	PUNCT
admet-2753	488	1	cyclodextrins	cyclodextrin	NOUN
admet-2753	488	2	and	and	CCONJ
admet-2753	488	3	drug	drug	NOUN
admet-2753	488	4	membrane	membrane	NOUN
admet-2753	488	5	permeation	permeation	NOUN
admet-2753	488	6	:	:	PUNCT
admet-2753	488	7	thermodynamic	thermodynamic	ADJ
admet-2753	488	8	considerations	consideration	NOUN
admet-2753	488	9	.	.	PUNCT
admet-2753	489	1	journal	journal	NOUN
admet-2753	489	2	of	of	ADP
admet-2753	489	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	489	4	sciences	science	NOUN
admet-2753	489	5	111	111	NUM
admet-2753	489	6	(	(	PUNCT
admet-2753	489	7	2022	2022	NUM
admet-2753	489	8	)	)	PUNCT
admet-2753	489	9	2571	2571	NUM
admet-2753	489	10	-	-	SYM
admet-2753	489	11	2580	2580	NUM
admet-2753	489	12	.	.	PUNCT
admet-2753	490	1	https://doi.org/https://doi.org/10.1016/j.xphs.2022.04.015	https://doi.org/https://doi.org/10.1016/j.xphs.2022.04.015	NOUN
admet-2753	490	2	[	[	X
admet-2753	490	3	36	36	NUM
admet-2753	490	4	]	]	X
admet-2753	490	5	y.l	y.l	PROPN
admet-2753	490	6	.	.	PROPN
admet-2753	490	7	hsieh	hsieh	PROPN
admet-2753	490	8	,	,	PUNCT
admet-2753	490	9	g.a	g.a	PROPN
admet-2753	490	10	.	.	PROPN
admet-2753	490	11	ilevbare	ilevbare	PROPN
admet-2753	490	12	,	,	PUNCT
admet-2753	491	1	b.	b.	PROPN
admet-2753	491	2	van	van	PROPN
admet-2753	491	3	eerdenbrugh	eerdenbrugh	PROPN
admet-2753	491	4	,	,	PUNCT
admet-2753	491	5	k.j	k.j	PROPN
admet-2753	491	6	.	.	PROPN
admet-2753	491	7	box	box	PROPN
admet-2753	491	8	,	,	PUNCT
admet-2753	491	9	m.v	m.v	PROPN
admet-2753	491	10	.	.	PROPN
admet-2753	491	11	sanchez	sanchez	PROPN
admet-2753	491	12	-	-	PUNCT
admet-2753	491	13	felix	felix	PROPN
admet-2753	491	14	,	,	PUNCT
admet-2753	491	15	l.s	l.s	PROPN
admet-2753	491	16	.	.	PROPN
admet-2753	491	17	taylor	taylor	PROPN
admet-2753	491	18	.	.	PUNCT
admet-2753	492	1	ph	ph	VERB
admet-2753	492	2	-	-	ADJ
admet-2753	492	3	induced	induced	ADJ
admet-2753	492	4	precipitation	precipitation	NOUN
admet-2753	492	5	behavior	behavior	NOUN
admet-2753	492	6	of	of	ADP
admet-2753	492	7	weakly	weakly	ADJ
admet-2753	492	8	basic	basic	ADJ
admet-2753	492	9	compounds	compound	NOUN
admet-2753	492	10	:	:	PUNCT
admet-2753	492	11	determination	determination	NOUN
admet-2753	492	12	of	of	ADP
admet-2753	492	13	extent	extent	NOUN
admet-2753	492	14	and	and	CCONJ
admet-2753	492	15	duration	duration	NOUN
admet-2753	492	16	of	of	ADP
admet-2753	492	17	supersaturation	supersaturation	NOUN
admet-2753	492	18	using	use	VERB
admet-2753	492	19	potentiometric	potentiometric	ADJ
admet-2753	492	20	titration	titration	NOUN
admet-2753	492	21	and	and	CCONJ
admet-2753	492	22	correlation	correlation	NOUN
admet-2753	492	23	to	to	ADP
admet-2753	492	24	solid	solid	ADJ
admet-2753	492	25	state	state	NOUN
admet-2753	492	26	properties	property	NOUN
admet-2753	492	27	.	.	PUNCT
admet-2753	493	1	pharmaceutical	pharmaceutical	ADJ
admet-2753	493	2	research	research	NOUN
admet-2753	493	3	29	29	NUM
admet-2753	493	4	(	(	PUNCT
admet-2753	493	5	2012	2012	NUM
admet-2753	493	6	)	)	PUNCT
admet-2753	493	7	2738	2738	NUM
admet-2753	493	8	-	-	SYM
admet-2753	493	9	2753	2753	NUM
admet-2753	493	10	.	.	PUNCT
admet-2753	494	1	https://doi.org/10.1007/s11095-012-0759-8	https://doi.org/10.1007/s11095-012-0759-8	NOUN
admet-2753	495	1	[	[	X
admet-2753	495	2	37	37	NUM
admet-2753	495	3	]	]	X
admet-2753	495	4	j.h	j.h	PROPN
admet-2753	495	5	.	.	PROPN
admet-2753	495	6	fagerberg	fagerberg	PROPN
admet-2753	495	7	,	,	PUNCT
admet-2753	495	8	y.	y.	PROPN
admet-2753	495	9	al	al	PROPN
admet-2753	495	10	-	-	PUNCT
admet-2753	495	11	tikriti	tikriti	PROPN
admet-2753	495	12	,	,	PUNCT
admet-2753	495	13	g.	g.	PROPN
admet-2753	495	14	ragnarsson	ragnarsson	PROPN
admet-2753	495	15	,	,	PUNCT
admet-2753	495	16	c.a.s	c.a.	VERB
admet-2753	495	17	.	.	PUNCT
admet-2753	495	18	bergström	bergström	NOUN
admet-2753	495	19	.	.	PUNCT
admet-2753	496	1	ethanol	ethanol	NOUN
admet-2753	496	2	effects	effect	NOUN
admet-2753	496	3	on	on	ADP
admet-2753	496	4	apparent	apparent	ADJ
admet-2753	496	5	solubility	solubility	NOUN
admet-2753	496	6	of	of	ADP
admet-2753	496	7	poorly	poorly	ADV
admet-2753	496	8	soluble	soluble	ADJ
admet-2753	496	9	drugs	drug	NOUN
admet-2753	496	10	in	in	ADP
admet-2753	496	11	simulated	simulated	ADJ
admet-2753	496	12	intestinal	intestinal	ADJ
admet-2753	496	13	fluid	fluid	NOUN
admet-2753	496	14	.	.	PUNCT
admet-2753	497	1	molecular	molecular	ADJ
admet-2753	497	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	497	3	9	9	NUM
admet-2753	497	4	(	(	PUNCT
admet-2753	497	5	2012	2012	NUM
admet-2753	497	6	)	)	PUNCT
admet-2753	497	7	1942	1942	NUM
admet-2753	497	8	-	-	SYM
admet-2753	497	9	1952	1952	NUM
admet-2753	497	10	.	.	PUNCT
admet-2753	498	1	https://doi.org/10.1021/mp2006467	https://doi.org/10.1021/mp2006467	X
admet-2753	499	1	[	[	X
admet-2753	499	2	38	38	NUM
admet-2753	499	3	]	]	PUNCT
admet-2753	499	4	h.	h.	PROPN
admet-2753	499	5	pataki	pataki	PROPN
admet-2753	499	6	,	,	PUNCT
admet-2753	499	7	i.	i.	PROPN
admet-2753	499	8	markovits	markovits	PROPN
admet-2753	499	9	,	,	PUNCT
admet-2753	499	10	b.	b.	PROPN
admet-2753	499	11	vajna	vajna	PROPN
admet-2753	499	12	,	,	PUNCT
admet-2753	499	13	z.k	z.k	PROPN
admet-2753	499	14	.	.	PROPN
admet-2753	499	15	nagy	nagy	PROPN
admet-2753	499	16	,	,	PUNCT
admet-2753	499	17	g.	g.	PROPN
admet-2753	499	18	marosi	marosi	PROPN
admet-2753	499	19	.	.	PUNCT
admet-2753	500	1	in	in	ADP
admet-2753	500	2	-	-	PUNCT
admet-2753	500	3	line	line	NOUN
admet-2753	500	4	monitoring	monitoring	NOUN
admet-2753	500	5	of	of	ADP
admet-2753	500	6	carvedilol	carvedilol	NOUN
admet-2753	500	7	crystallization	crystallization	NOUN
admet-2753	500	8	using	use	VERB
admet-2753	500	9	raman	raman	NOUN
admet-2753	500	10	spectroscopy	spectroscopy	NOUN
admet-2753	500	11	.	.	PUNCT
admet-2753	501	1	crystal	crystal	NOUN
admet-2753	501	2	growth	growth	PROPN
admet-2753	501	3	&	&	CCONJ
admet-2753	501	4	design	design	PROPN
admet-2753	501	5	12	12	NUM
admet-2753	501	6	(	(	PUNCT
admet-2753	501	7	2012	2012	NUM
admet-2753	501	8	)	)	PUNCT
admet-2753	501	9	5621	5621	NUM
admet-2753	501	10	-	-	SYM
admet-2753	501	11	5628	5628	NUM
admet-2753	501	12	.	.	PUNCT
admet-2753	502	1	https://doi.org/10.1021/cg301135z	https://doi.org/10.1021/cg301135z	PROPN
admet-2753	503	1	[	[	X
admet-2753	503	2	39	39	NUM
admet-2753	503	3	]	]	PUNCT
admet-2753	503	4	h.	h.	PROPN
admet-2753	503	5	pataki	pataki	PROPN
admet-2753	503	6	,	,	PUNCT
admet-2753	503	7	i.	i.	PROPN
admet-2753	503	8	csontos	csontos	PROPN
admet-2753	503	9	,	,	PUNCT
admet-2753	503	10	z.k	z.k	PROPN
admet-2753	503	11	.	.	PROPN
admet-2753	503	12	nagy	nagy	PROPN
admet-2753	503	13	,	,	PUNCT
admet-2753	503	14	b.	b.	PROPN
admet-2753	503	15	vajna	vajna	PROPN
admet-2753	503	16	,	,	PUNCT
admet-2753	503	17	m.	m.	PROPN
admet-2753	503	18	molnar	molnar	PROPN
admet-2753	503	19	,	,	PUNCT
admet-2753	503	20	l.	l.	PROPN
admet-2753	503	21	katona	katona	PROPN
admet-2753	503	22	,	,	PUNCT
admet-2753	503	23	g.	g.	PROPN
admet-2753	503	24	marosi	marosi	PROPN
admet-2753	503	25	.	.	PUNCT
admet-2753	504	1	implementation	implementation	NOUN
admet-2753	504	2	of	of	ADP
admet-2753	504	3	raman	raman	NOUN
admet-2753	504	4	signal	signal	NOUN
admet-2753	504	5	feedback	feedback	NOUN
admet-2753	504	6	to	to	PART
admet-2753	504	7	perform	perform	VERB
admet-2753	504	8	controlled	control	VERB
admet-2753	504	9	crystallization	crystallization	NOUN
admet-2753	504	10	of	of	ADP
admet-2753	504	11	carvedilol	carvedilol	NOUN
admet-2753	504	12	.	.	PUNCT
admet-2753	505	1	organic	organic	ADJ
admet-2753	505	2	process	process	NOUN
admet-2753	505	3	research	research	PROPN
admet-2753	505	4	&	&	CCONJ
admet-2753	505	5	development	development	PROPN
admet-2753	505	6	17	17	NUM
admet-2753	505	7	(	(	PUNCT
admet-2753	505	8	2013	2013	NUM
admet-2753	505	9	)	)	PUNCT
admet-2753	505	10	493	493	NUM
admet-2753	505	11	-	-	SYM
admet-2753	505	12	499	499	NUM
admet-2753	505	13	.	.	PUNCT
admet-2753	506	1	https://doi.org/10.1021/op300062	https://doi.org/10.1021/op300062	X
admet-2753	506	2	t	t	NOUN
admet-2753	507	1	[	[	X
admet-2753	507	2	40	40	NUM
admet-2753	507	3	]	]	PUNCT
admet-2753	507	4	a.	a.	NOUN
admet-2753	507	5	singh	singh	PROPN
admet-2753	507	6	,	,	PUNCT
admet-2753	507	7	m.	m.	NOUN
admet-2753	507	8	pallastrelli	pallastrelli	PROPN
admet-2753	507	9	,	,	PUNCT
admet-2753	507	10	m.	m.	PROPN
admet-2753	507	11	santoro	santoro	PROPN
admet-2753	507	12	.	.	PUNCT
admet-2753	508	1	direct	direct	ADJ
admet-2753	508	2	chiral	chiral	ADJ
admet-2753	508	3	separations	separation	NOUN
admet-2753	508	4	of	of	ADP
admet-2753	508	5	third	third	ADJ
admet-2753	508	6	generation	generation	NOUN
admet-2753	508	7	b	b	NOUN
admet-2753	508	8	-	-	PUNCT
admet-2753	508	9	blockers	blocker	NOUN
admet-2753	508	10	through	through	ADP
admet-2753	508	11	high	high	ADJ
admet-2753	508	12	performance	performance	NOUN
admet-2753	508	13	liquid	liquid	NOUN
admet-2753	508	14	chromatography	chromatography	NOUN
admet-2753	508	15	.	.	PUNCT
admet-2753	509	1	scientia	scientia	PROPN
admet-2753	509	2	chromatographica	chromatographica	PROPN
admet-2753	509	3	7	7	NUM
admet-2753	509	4	(	(	PUNCT
admet-2753	509	5	2015	2015	NUM
admet-2753	509	6	)	)	PUNCT
admet-2753	509	7	65	65	NUM
admet-2753	509	8	-	-	SYM
admet-2753	509	9	84	84	NUM
admet-2753	509	10	.	.	PUNCT
admet-2753	510	1	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generati	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generati	ADJ
admet-2753	510	2	on_b	on_b	NOUN
admet-2753	510	3	-	-	PUNCT
admet-2753	510	4	blockers_through_high_performance_liquid_chromatography_a_review	blockers_through_high_performance_liquid_chromatography_a_review	NOUN
admet-2753	510	5	[	[	X
admet-2753	510	6	41	41	NUM
admet-2753	510	7	]	]	X
admet-2753	510	8	n.a	n.a	PROPN
admet-2753	510	9	.	.	PROPN
admet-2753	510	10	al	al	PROPN
admet-2753	510	11	-	-	PUNCT
admet-2753	510	12	rawashdeh	rawashdeh	PROPN
admet-2753	510	13	,	,	PUNCT
admet-2753	510	14	k.s	k.s	PROPN
admet-2753	510	15	.	.	PUNCT
admet-2753	510	16	al	al	PROPN
admet-2753	510	17	-	-	PUNCT
admet-2753	510	18	sadeh	sadeh	PROPN
admet-2753	510	19	,	,	PUNCT
admet-2753	510	20	m.b	m.b	PROPN
admet-2753	510	21	.	.	PROPN
admet-2753	510	22	al	al	PROPN
admet-2753	510	23	-	-	PUNCT
admet-2753	510	24	bitar	bitar	PROPN
admet-2753	510	25	.	.	PUNCT
admet-2753	511	1	physicochemical	physicochemical	ADJ
admet-2753	511	2	study	study	NOUN
admet-2753	511	3	on	on	ADP
admet-2753	511	4	microencapsulation	microencapsulation	NOUN
admet-2753	511	5	of	of	ADP
admet-2753	511	6	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	511	7	-	-	PUNCT
admet-2753	511	8	beta	beta	NOUN
admet-2753	511	9	-	-	PUNCT
admet-2753	511	10	cyclodextrin	cyclodextrin	NOUN
admet-2753	511	11	in	in	ADP
admet-2753	511	12	dermal	dermal	ADJ
admet-2753	511	13	preparations	preparation	NOUN
admet-2753	511	14	.	.	PUNCT
admet-2753	512	1	drug	drug	NOUN
admet-2753	512	2	development	development	NOUN
admet-2753	512	3	and	and	CCONJ
admet-2753	512	4	industrial	industrial	ADJ
admet-2753	512	5	pharmacy	pharmacy	NOUN
admet-2753	512	6	36	36	NUM
admet-2753	512	7	(	(	PUNCT
admet-2753	512	8	2010	2010	NUM
admet-2753	512	9	)	)	PUNCT
admet-2753	512	10	688	688	NUM
admet-2753	512	11	-	-	SYM
admet-2753	512	12	697	697	NUM
admet-2753	512	13	.	.	PUNCT
admet-2753	512	14	https://doi.org/10.3109/03639040903449738	https://doi.org/10.3109/03639040903449738	NOUN
admet-2753	513	1	[	[	X
admet-2753	513	2	42	42	NUM
admet-2753	513	3	]	]	PUNCT
admet-2753	513	4	j.	j.	PROPN
admet-2753	513	5	karlsson	karlsson	PROPN
admet-2753	513	6	,	,	PUNCT
admet-2753	513	7	p.	p.	PROPN
admet-2753	513	8	artursson	artursson	PROPN
admet-2753	513	9	.	.	PUNCT
admet-2753	514	1	a	a	DET
admet-2753	514	2	method	method	NOUN
admet-2753	514	3	for	for	ADP
admet-2753	514	4	the	the	DET
admet-2753	514	5	determination	determination	NOUN
admet-2753	514	6	of	of	ADP
admet-2753	514	7	cellular	cellular	ADJ
admet-2753	514	8	permeability	permeability	NOUN
admet-2753	514	9	coefficients	coefficient	NOUN
admet-2753	514	10	and	and	CCONJ
admet-2753	514	11	aqueous	aqueous	ADJ
admet-2753	514	12	boundary	boundary	ADJ
admet-2753	514	13	layer	layer	NOUN
admet-2753	514	14	thickness	thickness	NOUN
admet-2753	514	15	in	in	ADP
admet-2753	514	16	monolayers	monolayer	NOUN
admet-2753	514	17	of	of	ADP
admet-2753	514	18	intestinal	intestinal	ADJ
admet-2753	514	19	epithelial	epithelial	ADJ
admet-2753	514	20	(	(	PUNCT
admet-2753	514	21	caco-2	caco-2	NOUN
admet-2753	514	22	)	)	PUNCT
admet-2753	514	23	cells	cell	NOUN
admet-2753	514	24	grown	grow	VERB
admet-2753	514	25	in	in	ADP
admet-2753	514	26	permeable	permeable	ADJ
admet-2753	514	27	filter	filter	NOUN
admet-2753	514	28	chambers	chamber	NOUN
admet-2753	514	29	.	.	PUNCT
admet-2753	515	1	international	international	ADJ
admet-2753	515	2	journal	journal	PROPN
admet-2753	515	3	of	of	ADP
admet-2753	515	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	515	5	71	71	NUM
admet-2753	515	6	(	(	PUNCT
admet-2753	515	7	1991	1991	NUM
admet-2753	515	8	)	)	PUNCT
admet-2753	515	9	55	55	NUM
admet-2753	515	10	-	-	SYM
admet-2753	515	11	64	64	NUM
admet-2753	515	12	.	.	PUNCT
admet-2753	515	13	https://doi.org/https://doi.org/10.1016/0378-5173(91)90067-x	https://doi.org/https://doi.org/10.1016/0378-5173(91)90067-x	PUNCT
admet-2753	516	1	[	[	X
admet-2753	516	2	43	43	NUM
admet-2753	516	3	]	]	PUNCT
admet-2753	516	4	a.	a.	PROPN
admet-2753	516	5	walter	walter	PROPN
admet-2753	516	6	,	,	PUNCT
admet-2753	516	7	j.	j.	PROPN
admet-2753	516	8	gutknecht	gutknecht	PROPN
admet-2753	516	9	.	.	PUNCT
admet-2753	517	1	monocarboxylic	monocarboxylic	ADJ
admet-2753	517	2	acid	acid	PROPN
admet-2753	517	3	permeation	permeation	NOUN
admet-2753	517	4	through	through	ADP
admet-2753	517	5	lipid	lipid	ADJ
admet-2753	517	6	bilayer	bilayer	NOUN
admet-2753	517	7	membranes	membrane	NOUN
admet-2753	517	8	.	.	PUNCT
admet-2753	518	1	the	the	DET
admet-2753	518	2	journal	journal	NOUN
admet-2753	518	3	of	of	ADP
admet-2753	518	4	membrane	membrane	NOUN
admet-2753	518	5	biology	biology	NOUN
admet-2753	518	6	77	77	NUM
admet-2753	518	7	(	(	PUNCT
admet-2753	518	8	1984	1984	NUM
admet-2753	518	9	)	)	PUNCT
admet-2753	518	10	255	255	NUM
admet-2753	518	11	-	-	SYM
admet-2753	518	12	264	264	NUM
admet-2753	518	13	.	.	PUNCT
admet-2753	518	14	https://doi.org/10.1007/bf01870573	https://doi.org/10.1007/bf01870573	X
admet-2753	519	1	[	[	X
admet-2753	519	2	44	44	NUM
admet-2753	519	3	]	]	PUNCT
admet-2753	519	4	j.	j.	PROPN
admet-2753	519	5	gutknecht	gutknecht	PROPN
admet-2753	519	6	,	,	PUNCT
admet-2753	519	7	m.a	m.a	PROPN
admet-2753	519	8	.	.	PROPN
admet-2753	519	9	bisson	bisson	PROPN
admet-2753	519	10	,	,	PUNCT
admet-2753	519	11	f.c	f.c	PROPN
admet-2753	519	12	.	.	PROPN
admet-2753	519	13	tosteson	tosteson	PROPN
admet-2753	519	14	.	.	PUNCT
admet-2753	520	1	diffusion	diffusion	NOUN
admet-2753	520	2	of	of	ADP
admet-2753	520	3	carbon	carbon	NOUN
admet-2753	520	4	dioxide	dioxide	NOUN
admet-2753	520	5	through	through	ADP
admet-2753	520	6	lipid	lipid	ADJ
admet-2753	520	7	bilayer	bilayer	NOUN
admet-2753	520	8	membranes	membrane	NOUN
admet-2753	520	9	:	:	PUNCT
admet-2753	520	10	effects	effect	NOUN
admet-2753	520	11	of	of	ADP
admet-2753	520	12	carbonic	carbonic	ADJ
admet-2753	520	13	anhydrase	anhydrase	NOUN
admet-2753	520	14	,	,	PUNCT
admet-2753	520	15	bicarbonate	bicarbonate	NOUN
admet-2753	520	16	,	,	PUNCT
admet-2753	520	17	and	and	CCONJ
admet-2753	520	18	unstirred	unstirred	ADJ
admet-2753	520	19	layers	layer	NOUN
admet-2753	520	20	.	.	PUNCT
admet-2753	521	1	journal	journal	PROPN
admet-2753	521	2	of	of	ADP
admet-2753	521	3	general	general	ADJ
admet-2753	521	4	physiology	physiology	NOUN
admet-2753	521	5	69	69	NUM
admet-2753	521	6	(	(	PUNCT
admet-2753	521	7	1977	1977	NUM
admet-2753	521	8	)	)	PUNCT
admet-2753	521	9	779	779	NUM
admet-2753	521	10	-	-	SYM
admet-2753	521	11	794	794	NUM
admet-2753	521	12	.	.	PUNCT
admet-2753	522	1	https://doi.org/10.1085/jgp.69.6.779	https://doi.org/10.1085/jgp.69.6.779	NOUN
admet-2753	522	2	[	[	X
admet-2753	522	3	45	45	NUM
admet-2753	522	4	]	]	PUNCT
admet-2753	522	5	j.	j.	PROPN
admet-2753	522	6	gutknecht	gutknecht	PROPN
admet-2753	522	7	,	,	PUNCT
admet-2753	522	8	d.c	d.c	PROPN
admet-2753	522	9	.	.	PROPN
admet-2753	522	10	tosteson	tosteson	PROPN
admet-2753	522	11	.	.	PUNCT
admet-2753	523	1	diffusion	diffusion	NOUN
admet-2753	523	2	of	of	ADP
admet-2753	523	3	weak	weak	ADJ
admet-2753	523	4	acids	acid	NOUN
admet-2753	523	5	across	across	ADP
admet-2753	523	6	lipid	lipid	ADJ
admet-2753	523	7	bilayer	bilayer	NOUN
admet-2753	523	8	membranes	membrane	NOUN
admet-2753	523	9	:	:	PUNCT
admet-2753	523	10	effects	effect	NOUN
admet-2753	523	11	of	of	ADP
admet-2753	523	12	chemical	chemical	ADJ
admet-2753	523	13	reactions	reaction	NOUN
admet-2753	523	14	in	in	ADP
admet-2753	523	15	the	the	DET
admet-2753	523	16	unstirred	unstirred	ADJ
admet-2753	523	17	layers	layer	NOUN
admet-2753	523	18	.	.	PUNCT
admet-2753	524	1	science	science	NOUN
admet-2753	524	2	182	182	NUM
admet-2753	524	3	(	(	PUNCT
admet-2753	524	4	1973	1973	NUM
admet-2753	524	5	)	)	PUNCT
admet-2753	524	6	1258	1258	NUM
admet-2753	524	7	-	-	SYM
admet-2753	524	8	1261	1261	NUM
admet-2753	524	9	.	.	PUNCT
admet-2753	525	1	https://doi.org/10.1126/science.182.4118.1258	https://doi.org/10.1126/science.182.4118.1258	X
admet-2753	526	1	[	[	X
admet-2753	526	2	46	46	NUM
admet-2753	526	3	]	]	PUNCT
admet-2753	526	4	a.	a.	NOUN
admet-2753	526	5	dahan	dahan	PROPN
admet-2753	526	6	,	,	PUNCT
admet-2753	526	7	j.m	j.m	PROPN
admet-2753	526	8	.	.	PROPN
admet-2753	526	9	miller	miller	PROPN
admet-2753	526	10	,	,	PUNCT
admet-2753	526	11	a.	a.	NOUN
admet-2753	526	12	hoffman	hoffman	PROPN
admet-2753	526	13	,	,	PUNCT
admet-2753	526	14	g.e	g.e	PROPN
admet-2753	526	15	.	.	PROPN
admet-2753	526	16	amidon	amidon	PROPN
admet-2753	526	17	,	,	PUNCT
admet-2753	526	18	g.l	g.l	PROPN
admet-2753	526	19	.	.	PROPN
admet-2753	526	20	amidon	amidon	PROPN
admet-2753	526	21	.	.	PUNCT
admet-2753	527	1	the	the	DET
admet-2753	527	2	solubility	solubility	NOUN
admet-2753	527	3	–	–	PUNCT
admet-2753	527	4	permeability	permeability	NOUN
admet-2753	527	5	interplay	interplay	NOUN
admet-2753	527	6	in	in	ADP
admet-2753	527	7	using	use	VERB
admet-2753	527	8	cyclodextrins	cyclodextrin	NOUN
admet-2753	527	9	as	as	ADP
admet-2753	527	10	pharmaceutical	pharmaceutical	ADJ
admet-2753	527	11	solubilizers	solubilizer	NOUN
admet-2753	527	12	:	:	PUNCT
admet-2753	527	13	mechanistic	mechanistic	ADJ
admet-2753	527	14	modeling	modeling	NOUN
admet-2753	527	15	and	and	CCONJ
admet-2753	527	16	application	application	NOUN
admet-2753	527	17	to	to	ADP
admet-2753	527	18	progesterone	progesterone	NOUN
admet-2753	527	19	.	.	PUNCT
admet-2753	528	1	journal	journal	PROPN
admet-2753	528	2	of	of	ADP
admet-2753	528	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	528	4	sciences	science	NOUN
admet-2753	528	5	99	99	NUM
admet-2753	528	6	(	(	PUNCT
admet-2753	528	7	2010	2010	NUM
admet-2753	528	8	)	)	PUNCT
admet-2753	528	9	2739	2739	NUM
admet-2753	528	10	-	-	SYM
admet-2753	528	11	2749	2749	NUM
admet-2753	528	12	.	.	PUNCT
admet-2753	529	1	https://doi.org/10.1002/jps.22033	https://doi.org/10.1002/jps.22033	VERB
admet-2753	529	2	[	[	PUNCT
admet-2753	529	3	47	47	NUM
admet-2753	529	4	]	]	X
admet-2753	529	5	e.	e.	PROPN
admet-2753	529	6	baka	baka	PROPN
admet-2753	529	7	,	,	PUNCT
admet-2753	529	8	j.e	j.e	PROPN
admet-2753	529	9	.	.	PROPN
admet-2753	529	10	comer	comer	PROPN
admet-2753	529	11	,	,	PUNCT
admet-2753	529	12	k.	k.	PROPN
admet-2753	529	13	takács	takács	PROPN
admet-2753	529	14	-	-	PUNCT
admet-2753	529	15	novák	novák	NOUN
admet-2753	529	16	.	.	PUNCT
admet-2753	530	1	study	study	NOUN
admet-2753	530	2	of	of	ADP
admet-2753	530	3	equilibrium	equilibrium	NOUN
admet-2753	530	4	solubility	solubility	NOUN
admet-2753	530	5	measurement	measurement	NOUN
admet-2753	530	6	by	by	ADP
admet-2753	530	7	saturation	saturation	NOUN
admet-2753	530	8	shake	shake	NOUN
admet-2753	530	9	-	-	PUNCT
admet-2753	530	10	flask	flask	NOUN
admet-2753	530	11	method	method	NOUN
admet-2753	530	12	using	use	VERB
admet-2753	530	13	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-2753	530	14	as	as	ADP
admet-2753	530	15	model	model	NOUN
admet-2753	530	16	compound	compound	PROPN
admet-2753	530	17	.	.	PUNCT
admet-2753	531	1	journal	journal	PROPN
admet-2753	531	2	of	of	ADP
admet-2753	531	3	pharmaceutical	pharmaceutical	NOUN
admet-2753	531	4	and	and	CCONJ
admet-2753	531	5	biomedical	biomedical	ADJ
admet-2753	531	6	analysis	analysis	NOUN
admet-2753	531	7	46	46	NUM
admet-2753	531	8	(	(	PUNCT
admet-2753	531	9	2008	2008	NUM
admet-2753	531	10	)	)	PUNCT
admet-2753	531	11	335	335	NUM
admet-2753	531	12	-	-	SYM
admet-2753	531	13	341	341	NUM
admet-2753	531	14	.	.	PUNCT
admet-2753	532	1	https://doi.org/10.1016/j.jpba.2007.10.030	https://doi.org/10.1016/j.jpba.2007.10.030	NOUN
admet-2753	532	2	[	[	X
admet-2753	532	3	48	48	NUM
admet-2753	532	4	]	]	PUNCT
admet-2753	532	5	a.	a.	NOUN
admet-2753	532	6	avdeef	avdeef	PROPN
admet-2753	532	7	,	,	PUNCT
admet-2753	532	8	e.	e.	PROPN
admet-2753	532	9	fuguet	fuguet	PROPN
admet-2753	532	10	,	,	PUNCT
admet-2753	532	11	a.	a.	PROPN
admet-2753	532	12	llinàs	llinàs	PROPN
admet-2753	532	13	,	,	PUNCT
admet-2753	532	14	c.	c.	PROPN
admet-2753	532	15	ràfols	ràfols	PROPN
admet-2753	532	16	,	,	PUNCT
admet-2753	532	17	e.	e.	PROPN
admet-2753	532	18	bosch	bosch	PROPN
admet-2753	532	19	,	,	PUNCT
admet-2753	532	20	g.	g.	PROPN
admet-2753	532	21	völgyi	völgyi	PROPN
admet-2753	532	22	,	,	PUNCT
admet-2753	532	23	t.	t.	NOUN
admet-2753	532	24	verbić	verbić	PROPN
admet-2753	532	25	,	,	PUNCT
admet-2753	532	26	e.	e.	PROPN
admet-2753	532	27	boldyreva	boldyreva	PROPN
admet-2753	532	28	,	,	PUNCT
admet-2753	532	29	k.	k.	PROPN
admet-2753	532	30	takács	takács	PROPN
admet-2753	532	31	-	-	PUNCT
admet-2753	532	32	novák	novák	PROPN
admet-2753	532	33	.	.	PUNCT
admet-2753	532	34	equilibrium	equilibrium	NOUN
admet-2753	532	35	solubility	solubility	NOUN
admet-2753	532	36	measurement	measurement	NOUN
admet-2753	532	37	of	of	ADP
admet-2753	532	38	ionizable	ionizable	ADJ
admet-2753	532	39	drugs	drug	NOUN
admet-2753	532	40	–	–	PUNCT
admet-2753	532	41	consensus	consensus	NOUN
admet-2753	532	42	recommendations	recommendation	NOUN
admet-2753	532	43	for	for	ADP
admet-2753	532	44	improving	improve	VERB
admet-2753	532	45	data	datum	NOUN
admet-2753	532	46	quality	quality	NOUN
admet-2753	532	47	.	.	PUNCT
admet-2753	533	1	admet	admet	PROPN
admet-2753	533	2	and	and	CCONJ
admet-2753	533	3	dmpk	dmpk	VERB
admet-2753	533	4	4	4	NUM
admet-2753	533	5	(	(	PUNCT
admet-2753	533	6	2016	2016	NUM
admet-2753	533	7	)	)	PUNCT
admet-2753	533	8	.	.	PUNCT
admet-2753	534	1	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-2753	534	2	https://doi.org/10.5599/admet.2753	https://doi.org/10.5599/admet.2753	NOUN
admet-2753	534	3	https://doi.org/10.1208/s12249-008-9055-7	https://doi.org/10.1208/s12249-008-9055-7	NUM
admet-2753	534	4	https://doi.org/10.1016/j.xphs.2020.10.026	https://doi.org/10.1016/j.xphs.2020.10.026	PROPN
admet-2753	534	5	https://doi.org/https:/doi.org/10.1016/j.xphs.2022.04.015	https://doi.org/https:/doi.org/10.1016/j.xphs.2022.04.015	VERB
admet-2753	534	6	https://doi.org/10.1007/s11095-012-0759-8	https://doi.org/10.1007/s11095-012-0759-8	NUM
admet-2753	534	7	https://doi.org/10.1021/mp2006467	https://doi.org/10.1021/mp2006467	PROPN
admet-2753	534	8	https://doi.org/10.1021/cg301135z	https://doi.org/10.1021/cg301135z	PROPN
admet-2753	534	9	https://doi.org/10.1021/op300062	https://doi.org/10.1021/op300062	PROPN
admet-2753	534	10	t	t	PROPN
admet-2753	534	11	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generation_b-blockers_through_high_performance_liquid_chromatography_a_review	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generation_b-blockers_through_high_performance_liquid_chromatography_a_review	VERB
admet-2753	534	12	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generation_b-blockers_through_high_performance_liquid_chromatography_a_review	https://www.researchgate.net/publication/281664439_direct_chiral_separations_of_third_generation_b-blockers_through_high_performance_liquid_chromatography_a_review	NOUN
admet-2753	534	13	https://doi.org/10.3109/03639040903449738	https://doi.org/10.3109/03639040903449738	NOUN
admet-2753	534	14	https://doi.org/https:/doi.org/10.1016/0378-5173(91)90067-x	https://doi.org/https:/doi.org/10.1016/0378-5173(91)90067-x	NOUN
admet-2753	534	15	https://doi.org/10.1007/bf01870573	https://doi.org/10.1007/bf01870573	X
admet-2753	534	16	https://doi.org/10.1085/jgp.69.6.779	https://doi.org/10.1085/jgp.69.6.779	PROPN
admet-2753	534	17	https://doi.org/10.1126/science.182.4118.1258	https://doi.org/10.1126/science.182.4118.1258	NOUN
admet-2753	534	18	https://doi.org/10.1002/jps.22033	https://doi.org/10.1002/jps.22033	VERB
admet-2753	534	19	https://doi.org/10.1016/j.jpba.2007.10.030	https://doi.org/10.1016/j.jpba.2007.10.030	NUM
admet-2753	534	20	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
admet-2753	534	21	p.	p.	NOUN
admet-2753	534	22	tőzsér	tőzsér	PROPN
admet-2753	534	23	et	et	PROPN
admet-2753	535	1	al	al	PROPN
admet-2753	535	2	.	.	PROPN
admet-2753	535	3	admet	admet	PROPN
admet-2753	535	4	&	&	CCONJ
admet-2753	535	5	dmpk	dmpk	PROPN
admet-2753	535	6	13(4	13(4	NUM
admet-2753	535	7	)	)	PUNCT
admet-2753	535	8	(	(	PUNCT
admet-2753	535	9	2025	2025	NUM
admet-2753	535	10	)	)	PUNCT
admet-2753	535	11	2753	2753	NUM
admet-2753	535	12	22	22	NUM
admet-2753	536	1	[	[	X
admet-2753	536	2	49	49	NUM
admet-2753	536	3	]	]	PUNCT
admet-2753	536	4	mettler	mettler	PROPN
admet-2753	536	5	-	-	PUNCT
admet-2753	536	6	toledo	toledo	PROPN
admet-2753	536	7	stare	stare	PROPN
admet-2753	536	8	evaluation	evaluation	NOUN
admet-2753	536	9	software	software	NOUN
admet-2753	536	10	.	.	PUNCT
admet-2753	537	1	https://www.mt.com/us/en/home/library/softwaredownloads/lab-analytical-instruments/stare_eval_sw.html	https://www.mt.com/us/en/home/library/softwaredownloads/lab-analytical-instruments/stare_eval_sw.html	PROPN
admet-2753	537	2	(	(	PUNCT
admet-2753	537	3	accessed	access	VERB
admet-2753	537	4	24	24	NUM
admet-2753	537	5	june	june	PROPN
admet-2753	537	6	2025	2025	NUM
admet-2753	537	7	)	)	PUNCT
admet-2753	538	1	[	[	X
admet-2753	538	2	50	50	NUM
admet-2753	538	3	]	]	PUNCT
admet-2753	538	4	perkinelmer	perkinelmer	PROPN
admet-2753	538	5	inc	inc	PROPN
admet-2753	538	6	.	.	PROPN
admet-2753	538	7	spectrum	spectrum	PROPN
admet-2753	538	8	software	software	NOUN
admet-2753	538	9	v5	v5	PROPN
admet-2753	538	10	0.1	0.1	NUM
admet-2753	538	11	,	,	PUNCT
admet-2753	538	12	https://shop.perkinelmer.com/product/l6100117	https://shop.perkinelmer.com/product/l6100117	VERB
admet-2753	538	13	(	(	PUNCT
admet-2753	538	14	accessed	access	VERB
admet-2753	538	15	24	24	NUM
admet-2753	538	16	june	june	PROPN
admet-2753	538	17	2025	2025	NUM
admet-2753	538	18	)	)	PUNCT
admet-2753	539	1	[	[	X
admet-2753	539	2	51	51	NUM
admet-2753	539	3	]	]	SYM
admet-2753	539	4	á	á	PROPN
admet-2753	539	5	.	.	PUNCT
admet-2753	539	6	buvári	buvári	PROPN
admet-2753	539	7	,	,	PUNCT
admet-2753	539	8	l.	l.	PROPN
admet-2753	539	9	barcza	barcza	PROPN
admet-2753	539	10	.	.	PUNCT
admet-2753	540	1	β	β	X
admet-2753	540	2	-	-	PUNCT
admet-2753	540	3	cyclodextrin	cyclodextrin	NOUN
admet-2753	540	4	complexes	complex	NOUN
admet-2753	540	5	of	of	ADP
admet-2753	540	6	different	different	ADJ
admet-2753	540	7	type	type	NOUN
admet-2753	540	8	with	with	ADP
admet-2753	540	9	inorganic	inorganic	ADJ
admet-2753	540	10	compounds	compound	NOUN
admet-2753	540	11	.	.	PUNCT
admet-2753	541	1	inorganica	inorganica	PROPN
admet-2753	541	2	chimica	chimica	PROPN
admet-2753	541	3	acta	acta	PROPN
admet-2753	541	4	33	33	NUM
admet-2753	541	5	(	(	PUNCT
admet-2753	541	6	1979	1979	NUM
admet-2753	541	7	)	)	PUNCT
admet-2753	542	1	l179	l179	PROPN
admet-2753	542	2	-	-	PUNCT
admet-2753	542	3	l180	l180	PROPN
admet-2753	542	4	.	.	PUNCT
admet-2753	542	5	https://doi.org/10.1016/s0020-1693(00)89441-4	https://doi.org/10.1016/s0020-1693(00)89441-4	PROPN
admet-2753	543	1	[	[	X
admet-2753	543	2	52	52	NUM
admet-2753	543	3	]	]	PUNCT
admet-2753	543	4	k.	k.	PROPN
admet-2753	543	5	sugano	sugano	PROPN
admet-2753	543	6	.	.	PUNCT
admet-2753	544	1	aqueous	aqueous	ADJ
admet-2753	544	2	boundary	boundary	ADJ
admet-2753	544	3	layers	layer	NOUN
admet-2753	544	4	related	relate	VERB
admet-2753	544	5	to	to	ADP
admet-2753	544	6	oral	oral	ADJ
admet-2753	544	7	absorption	absorption	NOUN
admet-2753	544	8	of	of	ADP
admet-2753	544	9	a	a	DET
admet-2753	544	10	drug	drug	NOUN
admet-2753	544	11	:	:	PUNCT
admet-2753	544	12	from	from	ADP
admet-2753	544	13	dissolution	dissolution	NOUN
admet-2753	544	14	of	of	ADP
admet-2753	544	15	a	a	DET
admet-2753	544	16	drug	drug	NOUN
admet-2753	544	17	to	to	ADP
admet-2753	544	18	carrier	carrier	NOUN
admet-2753	544	19	mediated	mediate	VERB
admet-2753	544	20	transport	transport	NOUN
admet-2753	544	21	and	and	CCONJ
admet-2753	544	22	intestinal	intestinal	ADJ
admet-2753	544	23	wall	wall	NOUN
admet-2753	544	24	metabolism	metabolism	NOUN
admet-2753	544	25	.	.	PUNCT
admet-2753	545	1	molecular	molecular	ADJ
admet-2753	545	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	545	3	7	7	NUM
admet-2753	545	4	(	(	PUNCT
admet-2753	545	5	2010	2010	NUM
admet-2753	545	6	)	)	PUNCT
admet-2753	545	7	1362	1362	NUM
admet-2753	545	8	-	-	SYM
admet-2753	545	9	1373	1373	NUM
admet-2753	545	10	.	.	PUNCT
admet-2753	546	1	https://doi.org/10.1021/mp1001119	https://doi.org/10.1021/mp1001119	PRON
admet-2753	547	1	[	[	X
admet-2753	547	2	53	53	NUM
admet-2753	547	3	]	]	PUNCT
admet-2753	547	4	t.	t.	PROPN
admet-2753	547	5	higuchi	higuchi	PROPN
admet-2753	547	6	,	,	PUNCT
admet-2753	547	7	k.a	k.a	PROPN
admet-2753	547	8	.	.	PROPN
admet-2753	547	9	connors	connor	NOUN
admet-2753	547	10	,	,	PUNCT
admet-2753	547	11	phase	phase	NOUN
admet-2753	547	12	solubility	solubility	NOUN
admet-2753	547	13	techniques	technique	NOUN
admet-2753	547	14	,	,	PUNCT
admet-2753	547	15	in	in	ADP
admet-2753	547	16	advanced	advanced	ADJ
admet-2753	547	17	analytical	analytical	ADJ
admet-2753	547	18	chemistry	chemistry	NOUN
admet-2753	547	19	of	of	ADP
admet-2753	547	20	instrumentation,1965	instrumentation,1965	NOUN
admet-2753	547	21	,	,	PUNCT
admet-2753	547	22	p.	p.	NOUN
admet-2753	547	23	117	117	NUM
admet-2753	547	24	-	-	SYM
admet-2753	547	25	212	212	NUM
admet-2753	547	26	.	.	PUNCT
admet-2753	548	1	https://doi.org/10.1016/b978-0-08-012210-6.50004-1	https://doi.org/10.1016/b978-0-08-012210-6.50004-1	PROPN
admet-2753	549	1	[	[	X
admet-2753	549	2	54	54	NUM
admet-2753	549	3	]	]	PUNCT
admet-2753	549	4	.	.	PUNCT
admet-2753	550	1	loftsson	loftsson	NOUN
admet-2753	550	2	,	,	PUNCT
admet-2753	550	3	p.	p.	PROPN
admet-2753	550	4	jarho	jarho	PROPN
admet-2753	550	5	,	,	PUNCT
admet-2753	550	6	m.	m.	NOUN
admet-2753	550	7	másson	másson	PROPN
admet-2753	550	8	,	,	PUNCT
admet-2753	550	9	t.	t.	PROPN
admet-2753	550	10	järvinen	järvinen	PROPN
admet-2753	550	11	.	.	PUNCT
admet-2753	551	1	cyclodextrins	cyclodextrin	NOUN
admet-2753	551	2	in	in	ADP
admet-2753	551	3	drug	drug	NOUN
admet-2753	551	4	delivery	delivery	NOUN
admet-2753	551	5	.	.	PUNCT
admet-2753	552	1	expert	expert	ADJ
admet-2753	552	2	opinion	opinion	NOUN
admet-2753	552	3	on	on	ADP
admet-2753	552	4	drug	drug	NOUN
admet-2753	552	5	delivery	delivery	NOUN
admet-2753	552	6	2	2	NUM
admet-2753	552	7	(	(	PUNCT
admet-2753	552	8	2005	2005	NUM
admet-2753	552	9	)	)	PUNCT
admet-2753	552	10	335	335	NUM
admet-2753	552	11	-	-	SYM
admet-2753	552	12	351	351	NUM
admet-2753	552	13	.	.	PUNCT
admet-2753	552	14	https://doi.org/10.1517/17425247.2.1.335	https://doi.org/10.1517/17425247.2.1.335	PROPN
admet-2753	553	1	[	[	X
admet-2753	553	2	55	55	NUM
admet-2753	553	3	]	]	X
admet-2753	553	4	m.e	m.e	PROPN
admet-2753	553	5	.	.	PROPN
admet-2753	553	6	brewster	brewster	NOUN
admet-2753	553	7	,	,	PUNCT
admet-2753	553	8	t.	t.	PROPN
admet-2753	553	9	loftsson	loftsson	NOUN
admet-2753	553	10	.	.	PUNCT
admet-2753	554	1	cyclodextrins	cyclodextrin	NOUN
admet-2753	554	2	as	as	ADP
admet-2753	554	3	pharmaceutical	pharmaceutical	ADJ
admet-2753	554	4	solubilizers	solubilizer	NOUN
admet-2753	554	5	.	.	PUNCT
admet-2753	555	1	advanced	advanced	ADJ
admet-2753	555	2	drug	drug	NOUN
admet-2753	555	3	delivery	delivery	NOUN
admet-2753	555	4	reviews	review	VERB
admet-2753	555	5	59	59	NUM
admet-2753	555	6	(	(	PUNCT
admet-2753	555	7	2007	2007	NUM
admet-2753	555	8	)	)	PUNCT
admet-2753	555	9	645	645	NUM
admet-2753	555	10	-	-	SYM
admet-2753	555	11	666	666	NUM
admet-2753	555	12	.	.	PUNCT
admet-2753	556	1	https://doi.org/10.1016/j.addr.2007.05.012	https://doi.org/10.1016/j.addr.2007.05.012	PROPN
admet-2753	556	2	[	[	X
admet-2753	556	3	56	56	NUM
admet-2753	556	4	]	]	X
admet-2753	556	5	a.r	a.r	PROPN
admet-2753	556	6	.	.	PROPN
admet-2753	556	7	sá	sá	PROPN
admet-2753	556	8	couto	couto	PROPN
admet-2753	556	9	,	,	PUNCT
admet-2753	556	10	a.	a.	PROPN
admet-2753	556	11	ryzhakov	ryzhakov	PROPN
admet-2753	556	12	,	,	PUNCT
admet-2753	556	13	t.	t.	PROPN
admet-2753	556	14	loftsson	loftsson	NOUN
admet-2753	556	15	.	.	PUNCT
admet-2753	557	1	2	2	NUM
admet-2753	557	2	-	-	PUNCT
admet-2753	557	3	hydroxypropyl	hydroxypropyl	NOUN
admet-2753	557	4	-	-	PUNCT
admet-2753	557	5	β	β	NOUN
admet-2753	557	6	-	-	PUNCT
admet-2753	557	7	cyclodextrin	cyclodextrin	NOUN
admet-2753	557	8	aggregates	aggregate	NOUN
admet-2753	557	9	:	:	PUNCT
admet-2753	557	10	identification	identification	NOUN
admet-2753	557	11	and	and	CCONJ
admet-2753	557	12	development	development	NOUN
admet-2753	557	13	of	of	ADP
admet-2753	557	14	analytical	analytical	ADJ
admet-2753	557	15	techniques	technique	NOUN
admet-2753	557	16	.	.	PUNCT
admet-2753	558	1	materials	material	NOUN
admet-2753	558	2	11	11	NUM
admet-2753	558	3	(	(	PUNCT
admet-2753	558	4	2018	2018	NUM
admet-2753	558	5	)	)	PUNCT
admet-2753	558	6	1971	1971	NUM
admet-2753	558	7	.	.	PUNCT
admet-2753	559	1	https://doi.org/10.3390/ma11101971	https://doi.org/10.3390/ma11101971	X
admet-2753	560	1	[	[	X
admet-2753	560	2	57	57	NUM
admet-2753	560	3	]	]	X
admet-2753	560	4	patient	patient	ADJ
admet-2753	560	5	information	information	NOUN
admet-2753	560	6	of	of	ADP
admet-2753	560	7	sporanox	sporanox	NOUN
admet-2753	560	8	(	(	PUNCT
admet-2753	560	9	itraconazole	itraconazole	NOUN
admet-2753	560	10	)	)	PUNCT
admet-2753	560	11	capsules	capsule	NOUN
admet-2753	560	12	.	.	PUNCT
admet-2753	561	1	https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020083s062lbl.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020083s062lbl.pdf	PUNCT
admet-2753	561	2	(	(	PUNCT
admet-2753	561	3	accessed	access	VERB
admet-2753	561	4	24	24	NUM
admet-2753	561	5	june	june	PROPN
admet-2753	561	6	2025	2025	NUM
admet-2753	561	7	)	)	PUNCT
admet-2753	562	1	[	[	X
admet-2753	562	2	58	58	NUM
admet-2753	562	3	]	]	PUNCT
admet-2753	562	4	a.	a.	PROPN
admet-2753	562	5	dahan	dahan	PROPN
admet-2753	562	6	,	,	PUNCT
admet-2753	562	7	j.m	j.m	PROPN
admet-2753	562	8	.	.	PROPN
admet-2753	562	9	miller	miller	PROPN
admet-2753	562	10	,	,	PUNCT
admet-2753	562	11	a.	a.	NOUN
admet-2753	562	12	hoffman	hoffman	PROPN
admet-2753	562	13	,	,	PUNCT
admet-2753	562	14	g.e	g.e	PROPN
admet-2753	562	15	.	.	PROPN
admet-2753	562	16	amidon	amidon	PROPN
admet-2753	562	17	,	,	PUNCT
admet-2753	562	18	g.l	g.l	PROPN
admet-2753	562	19	.	.	PROPN
admet-2753	562	20	amidon	amidon	PROPN
admet-2753	562	21	.	.	PUNCT
admet-2753	563	1	the	the	DET
admet-2753	563	2	solubility	solubility	NOUN
admet-2753	563	3	-	-	PUNCT
admet-2753	563	4	permeability	permeability	NOUN
admet-2753	563	5	interplay	interplay	NOUN
admet-2753	563	6	in	in	ADP
admet-2753	563	7	using	use	VERB
admet-2753	563	8	cyclodextrins	cyclodextrin	NOUN
admet-2753	563	9	as	as	ADP
admet-2753	563	10	pharmaceutical	pharmaceutical	ADJ
admet-2753	563	11	solubilizers	solubilizer	NOUN
admet-2753	563	12	:	:	PUNCT
admet-2753	563	13	mechanistic	mechanistic	ADJ
admet-2753	563	14	modeling	modeling	NOUN
admet-2753	563	15	and	and	CCONJ
admet-2753	563	16	application	application	NOUN
admet-2753	563	17	to	to	ADP
admet-2753	563	18	progesterone	progesterone	NOUN
admet-2753	563	19	.	.	PUNCT
admet-2753	564	1	journal	journal	PROPN
admet-2753	564	2	of	of	ADP
admet-2753	564	3	pharmaceutical	pharmaceutical	PROPN
admet-2753	564	4	sciences	science	NOUN
admet-2753	564	5	99	99	NUM
admet-2753	564	6	(	(	PUNCT
admet-2753	564	7	2010	2010	NUM
admet-2753	564	8	)	)	PUNCT
admet-2753	564	9	2739	2739	NUM
admet-2753	564	10	-	-	SYM
admet-2753	564	11	2749	2749	NUM
admet-2753	564	12	.	.	PUNCT
admet-2753	565	1	https://doi.org/10.1002/jps.22033	https://doi.org/10.1002/jps.22033	VERB
admet-2753	565	2	[	[	PUNCT
admet-2753	565	3	59	59	NUM
admet-2753	565	4	]	]	X
admet-2753	565	5	j.m	j.m	PROPN
admet-2753	565	6	.	.	PROPN
admet-2753	565	7	miller	miller	PROPN
admet-2753	565	8	,	,	PUNCT
admet-2753	565	9	a.	a.	PROPN
admet-2753	565	10	beig	beig	PROPN
admet-2753	565	11	,	,	PUNCT
admet-2753	565	12	b.j	b.j	PROPN
admet-2753	565	13	.	.	PROPN
admet-2753	565	14	krieg	krieg	PROPN
admet-2753	565	15	,	,	PUNCT
admet-2753	565	16	r.a	r.a	PROPN
admet-2753	565	17	.	.	PROPN
admet-2753	565	18	carr	carr	PROPN
admet-2753	565	19	,	,	PUNCT
admet-2753	565	20	t.b	t.b	PROPN
admet-2753	565	21	.	.	PROPN
admet-2753	565	22	borchardt	borchardt	PROPN
admet-2753	565	23	,	,	PUNCT
admet-2753	565	24	g.e	g.e	PROPN
admet-2753	565	25	.	.	PROPN
admet-2753	565	26	amidon	amidon	PROPN
admet-2753	565	27	,	,	PUNCT
admet-2753	565	28	g.l	g.l	PROPN
admet-2753	565	29	.	.	PROPN
admet-2753	565	30	amidon	amidon	PROPN
admet-2753	565	31	,	,	PUNCT
admet-2753	565	32	a.	a.	PROPN
admet-2753	565	33	dahan	dahan	PROPN
admet-2753	565	34	.	.	PUNCT
admet-2753	566	1	the	the	DET
admet-2753	566	2	solubility	solubility	NOUN
admet-2753	566	3	-	-	PUNCT
admet-2753	566	4	permeability	permeability	NOUN
admet-2753	566	5	interplay	interplay	NOUN
admet-2753	566	6	:	:	PUNCT
admet-2753	566	7	mechanistic	mechanistic	ADJ
admet-2753	566	8	modeling	modeling	NOUN
admet-2753	566	9	and	and	CCONJ
admet-2753	566	10	predictive	predictive	ADJ
admet-2753	566	11	application	application	NOUN
admet-2753	566	12	of	of	ADP
admet-2753	566	13	the	the	DET
admet-2753	566	14	impact	impact	NOUN
admet-2753	566	15	of	of	ADP
admet-2753	566	16	micellar	micellar	ADJ
admet-2753	566	17	solubilization	solubilization	NOUN
admet-2753	566	18	on	on	ADP
admet-2753	566	19	intestinal	intestinal	ADJ
admet-2753	566	20	permeation	permeation	NOUN
admet-2753	566	21	.	.	PUNCT
admet-2753	567	1	molecular	molecular	ADJ
admet-2753	567	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	567	3	8	8	NUM
admet-2753	567	4	(	(	PUNCT
admet-2753	567	5	2011	2011	NUM
admet-2753	567	6	)	)	PUNCT
admet-2753	567	7	1848	1848	NUM
admet-2753	567	8	-	-	SYM
admet-2753	567	9	1856	1856	NUM
admet-2753	567	10	.	.	PUNCT
admet-2753	568	1	https://doi.org/10.1021/mp200181v	https://doi.org/10.1021/mp200181v	X
admet-2753	569	1	[	[	X
admet-2753	569	2	60	60	NUM
admet-2753	569	3	]	]	PUNCT
admet-2753	569	4	k.	k.	PROPN
admet-2753	569	5	sugano	sugano	PROPN
admet-2753	569	6	.	.	PUNCT
admet-2753	570	1	estimation	estimation	NOUN
admet-2753	570	2	of	of	ADP
admet-2753	570	3	effective	effective	ADJ
admet-2753	570	4	intestinal	intestinal	ADJ
admet-2753	570	5	membrane	membrane	NOUN
admet-2753	570	6	permeability	permeability	NOUN
admet-2753	570	7	considering	consider	VERB
admet-2753	570	8	bile	bile	NOUN
admet-2753	570	9	micelle	micelle	NOUN
admet-2753	570	10	solubilisation	solubilisation	NOUN
admet-2753	570	11	.	.	PUNCT
admet-2753	571	1	international	international	ADJ
admet-2753	571	2	journal	journal	PROPN
admet-2753	571	3	of	of	ADP
admet-2753	571	4	pharmaceutics	pharmaceutic	NOUN
admet-2753	571	5	368	368	NUM
admet-2753	571	6	(	(	PUNCT
admet-2753	571	7	2009	2009	NUM
admet-2753	571	8	)	)	PUNCT
admet-2753	571	9	116	116	NUM
admet-2753	571	10	-	-	SYM
admet-2753	571	11	122	122	NUM
admet-2753	571	12	.	.	PUNCT
admet-2753	572	1	https://doi.org/https://doi.org/10.1016/j.ijpharm.2008.10.001	https://doi.org/https://doi.org/10.1016/j.ijpharm.2008.10.001	PROPN
admet-2753	573	1	[	[	X
admet-2753	573	2	61	61	NUM
admet-2753	573	3	]	]	PUNCT
admet-2753	573	4	k.	k.	PROPN
admet-2753	573	5	sugano	sugano	PROPN
admet-2753	573	6	,	,	PUNCT
admet-2753	573	7	m.	m.	NOUN
admet-2753	573	8	kataoka	kataoka	PROPN
admet-2753	573	9	,	,	PUNCT
admet-2753	573	10	c.	c.	PROPN
admet-2753	573	11	mathews	mathews	PROPN
admet-2753	573	12	cda	cda	PROPN
admet-2753	573	13	,	,	PUNCT
admet-2753	573	14	s.	s.	PROPN
admet-2753	573	15	yamashita	yamashita	PROPN
admet-2753	573	16	.	.	PUNCT
admet-2753	574	1	prediction	prediction	NOUN
admet-2753	574	2	of	of	ADP
admet-2753	574	3	food	food	NOUN
admet-2753	574	4	effect	effect	NOUN
admet-2753	574	5	by	by	ADP
admet-2753	574	6	bile	bile	NOUN
admet-2753	574	7	micelles	micelle	NOUN
admet-2753	574	8	on	on	ADP
admet-2753	574	9	oral	oral	ADJ
admet-2753	574	10	drug	drug	NOUN
admet-2753	574	11	absorption	absorption	NOUN
admet-2753	574	12	considering	consider	VERB
admet-2753	574	13	free	free	ADJ
admet-2753	574	14	fraction	fraction	NOUN
admet-2753	574	15	in	in	ADP
admet-2753	574	16	intestinal	intestinal	ADJ
admet-2753	574	17	fluid	fluid	NOUN
admet-2753	574	18	.	.	PUNCT
admet-2753	575	1	european	european	ADJ
admet-2753	575	2	journal	journal	PROPN
admet-2753	575	3	of	of	ADP
admet-2753	575	4	pharmaceutical	pharmaceutical	PROPN
admet-2753	575	5	sciences	science	NOUN
admet-2753	575	6	40	40	NUM
admet-2753	575	7	(	(	PUNCT
admet-2753	575	8	2010	2010	NUM
admet-2753	575	9	)	)	PUNCT
admet-2753	575	10	118	118	NUM
admet-2753	575	11	-	-	SYM
admet-2753	575	12	124	124	NUM
admet-2753	575	13	.	.	PUNCT
admet-2753	576	1	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-2753	576	2	[	[	X
admet-2753	576	3	62	62	NUM
admet-2753	576	4	]	]	PUNCT
admet-2753	576	5	e.	e.	PROPN
admet-2753	576	6	borbás	borbás	PROPN
admet-2753	576	7	,	,	PUNCT
admet-2753	576	8	b.	b.	PROPN
admet-2753	576	9	sinkó	sinkó	PROPN
admet-2753	576	10	,	,	PUNCT
admet-2753	576	11	o.	o.	PROPN
admet-2753	576	12	tsinman	tsinman	PROPN
admet-2753	576	13	,	,	PUNCT
admet-2753	576	14	k.	k.	PROPN
admet-2753	576	15	tsinman	tsinman	PROPN
admet-2753	576	16	,	,	PUNCT
admet-2753	576	17	é	é	PROPN
admet-2753	576	18	.	.	PUNCT
admet-2753	576	19	kiserdei	kiserdei	PROPN
admet-2753	576	20	,	,	PUNCT
admet-2753	576	21	b.	b.	PROPN
admet-2753	576	22	démuth	démuth	PROPN
admet-2753	576	23	,	,	PUNCT
admet-2753	576	24	a.	a.	PROPN
admet-2753	576	25	balogh	balogh	PROPN
admet-2753	576	26	,	,	PUNCT
admet-2753	576	27	b.	b.	PROPN
admet-2753	576	28	bodák	bodák	PROPN
admet-2753	576	29	,	,	PUNCT
admet-2753	576	30	a.	a.	NOUN
admet-2753	576	31	domokos	domokos	PROPN
admet-2753	576	32	,	,	PUNCT
admet-2753	576	33	g.	g.	PROPN
admet-2753	576	34	dargó	dargó	PROPN
admet-2753	576	35	,	,	PUNCT
admet-2753	576	36	g.t	g.t	PROPN
admet-2753	576	37	.	.	PROPN
admet-2753	576	38	balogh	balogh	PROPN
admet-2753	576	39	,	,	PUNCT
admet-2753	576	40	z.k	z.k	PROPN
admet-2753	576	41	.	.	PROPN
admet-2753	576	42	nagy	nagy	PROPN
admet-2753	576	43	.	.	PUNCT
admet-2753	577	1	investigation	investigation	NOUN
admet-2753	577	2	and	and	CCONJ
admet-2753	577	3	mathematical	mathematical	ADJ
admet-2753	577	4	description	description	NOUN
admet-2753	577	5	of	of	ADP
admet-2753	577	6	the	the	DET
admet-2753	577	7	real	real	ADJ
admet-2753	577	8	driving	driving	NOUN
admet-2753	577	9	force	force	NOUN
admet-2753	577	10	of	of	ADP
admet-2753	577	11	passive	passive	ADJ
admet-2753	577	12	transport	transport	NOUN
admet-2753	577	13	of	of	ADP
admet-2753	577	14	drug	drug	NOUN
admet-2753	577	15	molecules	molecule	NOUN
admet-2753	577	16	from	from	ADP
admet-2753	577	17	supersaturated	supersaturated	ADJ
admet-2753	577	18	solutions	solution	NOUN
admet-2753	577	19	.	.	PUNCT
admet-2753	578	1	molecular	molecular	ADJ
admet-2753	578	2	pharmaceutics	pharmaceutic	NOUN
admet-2753	578	3	13	13	NUM
admet-2753	578	4	(	(	PUNCT
admet-2753	578	5	2016	2016	NUM
admet-2753	578	6	)	)	PUNCT
admet-2753	578	7	3816	3816	NUM
admet-2753	578	8	-	-	SYM
admet-2753	578	9	3826	3826	NUM
admet-2753	578	10	.	.	PUNCT
admet-2753	579	1	https://doi.org/10.1021/acs.molpharmaceut.6b00613	https://doi.org/10.1021/acs.molpharmaceut.6b00613	ADJ
admet-2753	579	2	©	©	PROPN
admet-2753	579	3	2025	2025	NUM
admet-2753	579	4	by	by	ADP
admet-2753	579	5	the	the	DET
admet-2753	579	6	authors	author	NOUN
admet-2753	579	7	;	;	PUNCT
admet-2753	579	8	licensee	licensee	PROPN
admet-2753	579	9	iapc	iapc	PROPN
admet-2753	579	10	,	,	PUNCT
admet-2753	579	11	zagreb	zagreb	PROPN
admet-2753	579	12	,	,	PUNCT
admet-2753	579	13	croatia	croatia	PROPN
admet-2753	579	14	.	.	PUNCT
admet-2753	580	1	this	this	DET
admet-2753	580	2	article	article	NOUN
admet-2753	580	3	is	be	AUX
admet-2753	580	4	an	an	DET
admet-2753	580	5	open	open	ADJ
admet-2753	580	6	-	-	PUNCT
admet-2753	580	7	access	access	NOUN
admet-2753	580	8	article	article	NOUN
admet-2753	580	9	distributed	distribute	VERB
admet-2753	580	10	under	under	ADP
admet-2753	580	11	the	the	DET
admet-2753	580	12	terms	term	NOUN
admet-2753	580	13	and	and	CCONJ
admet-2753	580	14	conditions	condition	NOUN
admet-2753	580	15	of	of	ADP
admet-2753	580	16	the	the	DET
admet-2753	580	17	creative	creative	ADJ
admet-2753	580	18	commons	common	NOUN
admet-2753	580	19	attribution	attribution	NOUN
admet-2753	580	20	license	license	NOUN
admet-2753	580	21	(	(	PUNCT
admet-2753	580	22	(	(	PUNCT
admet-2753	580	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2753	580	24	)	)	PUNCT
admet-2753	580	25	https://www.mt.com/us/en/home/library/software-downloads/lab-analytical-instruments/stare_eval_sw.html	https://www.mt.com/us/en/home/library/software-downloads/lab-analytical-instruments/stare_eval_sw.html	PROPN
admet-2753	581	1	https://www.mt.com/us/en/home/library/software-downloads/lab-analytical-instruments/stare_eval_sw.html	https://www.mt.com/us/en/home/library/software-downloads/lab-analytical-instruments/stare_eval_sw.html	PROPN
admet-2753	581	2	https://shop.perkinelmer.com/product/l6100117	https://shop.perkinelmer.com/product/l6100117	VERB
admet-2753	581	3	https://doi.org/10.1016/s0020-1693(00)89441-4	https://doi.org/10.1016/s0020-1693(00)89441-4	PROPN
admet-2753	582	1	https://doi.org/10.1021/mp1001119	https://doi.org/10.1021/mp1001119	PROPN
admet-2753	582	2	https://doi.org/10.1016/b978-0-08-012210-6.50004-1	https://doi.org/10.1016/b978-0-08-012210-6.50004-1	PROPN
admet-2753	582	3	https://doi.org/10.1517/17425247.2.1.335	https://doi.org/10.1517/17425247.2.1.335	NOUN
admet-2753	582	4	https://doi.org/10.1016/j.addr.2007.05.012	https://doi.org/10.1016/j.addr.2007.05.012	PROPN
admet-2753	582	5	https://doi.org/10.3390/ma11101971	https://doi.org/10.3390/ma11101971	PUNCT
admet-2753	582	6	https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020083s062lbl.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020083s062lbl.pdf	PROPN
admet-2753	582	7	https://doi.org/10.1002/jps.22033	https://doi.org/10.1002/jps.22033	PROPN
admet-2753	582	8	https://doi.org/10.1021/mp200181v	https://doi.org/10.1021/mp200181v	X
admet-2753	582	9	https://doi.org/https:/doi.org/10.1016/j.ijpharm.2008.10.001	https://doi.org/https:/doi.org/10.1016/j.ijpharm.2008.10.001	NOUN
admet-2753	582	10	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-2753	582	11	https://doi.org/10.1021/acs.molpharmaceut.6b00613	https://doi.org/10.1021/acs.molpharmaceut.6b00613	PRON
admet-2753	582	12	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2753	582	13	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN