id	sid	tid	token	lemma	pos
admet-2756	1	1	targeting	target	VERB
admet-2756	1	2	bone	bone	NOUN
admet-2756	1	3	in	in	ADP
admet-2756	1	4	cancer	cancer	NOUN
admet-2756	1	5	therapy	therapy	NOUN
admet-2756	1	6	:	:	PUNCT
admet-2756	1	7	advances	advance	NOUN
admet-2756	1	8	and	and	CCONJ
admet-2756	1	9	challenges	challenge	NOUN
admet-2756	1	10	of	of	ADP
admet-2756	1	11	bisphosphonate	bisphosphonate	NOUN
admet-2756	1	12	-	-	PUNCT
admet-2756	1	13	based	base	VERB
admet-2756	1	14	drug	drug	NOUN
admet-2756	1	15	delivery	delivery	NOUN
admet-2756	1	16	systems	system	NOUN
admet-2756	1	17	doi	doi	NOUN
admet-2756	1	18	:	:	PUNCT
admet-2756	1	19	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	1	20	1	1	NUM
admet-2756	1	21	admet	admet	X
admet-2756	1	22	&	&	CCONJ
admet-2756	1	23	dmpk	dmpk	PROPN
admet-2756	1	24	13(3	13(3	NUM
admet-2756	1	25	)	)	PUNCT
admet-2756	1	26	(	(	PUNCT
admet-2756	1	27	2025	2025	NUM
admet-2756	1	28	)	)	PUNCT
admet-2756	1	29	2756	2756	NUM
admet-2756	1	30	;	;	PUNCT
admet-2756	1	31	doi	doi	NOUN
admet-2756	1	32	:	:	PUNCT
admet-2756	1	33	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	X
admet-2756	1	34	open	open	ADJ
admet-2756	1	35	access	access	NOUN
admet-2756	1	36	:	:	PUNCT
admet-2756	1	37	issn	issn	PROPN
admet-2756	1	38	:	:	PUNCT
admet-2756	1	39	1848	1848	NUM
admet-2756	1	40	-	-	SYM
admet-2756	1	41	7718	7718	NUM
admet-2756	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2756	1	43	review	review	NOUN
admet-2756	1	44	targeting	target	VERB
admet-2756	1	45	bone	bone	NOUN
admet-2756	1	46	in	in	ADP
admet-2756	1	47	cancer	cancer	NOUN
admet-2756	1	48	therapy	therapy	NOUN
admet-2756	1	49	:	:	PUNCT
admet-2756	1	50	advances	advance	NOUN
admet-2756	1	51	and	and	CCONJ
admet-2756	1	52	challenges	challenge	NOUN
admet-2756	1	53	of	of	ADP
admet-2756	1	54	bisphosphonate	bisphosphonate	NOUN
admet-2756	1	55	-	-	PUNCT
admet-2756	1	56	based	base	VERB
admet-2756	1	57	drug	drug	NOUN
admet-2756	1	58	delivery	delivery	NOUN
admet-2756	1	59	systems	system	NOUN
admet-2756	1	60	mohammadmahdi	mohammadmahdi	PROPN
admet-2756	1	61	eshaghi1	eshaghi1	PROPN
admet-2756	1	62	,	,	PUNCT
admet-2756	1	63	fariba	fariba	PROPN
admet-2756	1	64	ganji1	ganji1	PROPN
admet-2756	1	65	,	,	PUNCT
admet-2756	1	66	*	*	PROPN
admet-2756	1	67	,	,	PUNCT
admet-2756	1	68	hossein	hossein	PROPN
admet-2756	1	69	shaki1	shaki1	PROPN
admet-2756	1	70	and	and	CCONJ
admet-2756	1	71	lobat	lobat	VERB
admet-2756	1	72	tayebi2	tayebi2	ADJ
admet-2756	1	73	1biomedical	1biomedical	NUM
admet-2756	1	74	engineering	engineering	NOUN
admet-2756	1	75	group	group	NOUN
admet-2756	1	76	,	,	PUNCT
admet-2756	1	77	faculty	faculty	NOUN
admet-2756	1	78	of	of	ADP
admet-2756	1	79	chemical	chemical	ADJ
admet-2756	1	80	engineering	engineering	NOUN
admet-2756	1	81	,	,	PUNCT
admet-2756	1	82	tarbiat	tarbiat	PROPN
admet-2756	1	83	modares	modares	PROPN
admet-2756	1	84	university	university	PROPN
admet-2756	1	85	,	,	PUNCT
admet-2756	1	86	p.o	p.o	PROPN
admet-2756	1	87	.	.	PROPN
admet-2756	1	88	box	box	PROPN
admet-2756	1	89	:	:	PUNCT
admet-2756	1	90	14115	14115	NUM
admet-2756	1	91	-	-	SYM
admet-2756	1	92	143	143	NUM
admet-2756	1	93	,	,	PUNCT
admet-2756	1	94	tehran	tehran	PROPN
admet-2756	1	95	,	,	PUNCT
admet-2756	1	96	iran	iran	PROPN
admet-2756	1	97	2institute	2institute	NUM
admet-2756	1	98	for	for	ADP
admet-2756	1	99	engineering	engineering	NOUN
admet-2756	1	100	in	in	ADP
admet-2756	1	101	medicine	medicine	NOUN
admet-2756	1	102	,	,	PUNCT
admet-2756	1	103	health	health	NOUN
admet-2756	1	104	,	,	PUNCT
admet-2756	1	105	&	&	CCONJ
admet-2756	1	106	human	human	ADJ
admet-2756	1	107	performance	performance	NOUN
admet-2756	1	108	(	(	PUNCT
admet-2756	1	109	enmed	enmed	PROPN
admet-2756	1	110	)	)	PUNCT
admet-2756	1	111	,	,	PUNCT
admet-2756	1	112	batten	batten	PROPN
admet-2756	1	113	college	college	NOUN
admet-2756	1	114	of	of	ADP
admet-2756	1	115	engineering	engineering	NOUN
admet-2756	1	116	and	and	CCONJ
admet-2756	1	117	technology	technology	NOUN
admet-2756	1	118	,	,	PUNCT
admet-2756	1	119	old	old	ADJ
admet-2756	1	120	dominion	dominion	NOUN
admet-2756	1	121	university	university	PROPN
admet-2756	1	122	,	,	PUNCT
admet-2756	1	123	norfolk	norfolk	PROPN
admet-2756	1	124	,	,	PUNCT
admet-2756	1	125	va	va	PROPN
admet-2756	1	126	,	,	PUNCT
admet-2756	1	127	23529	23529	NUM
admet-2756	1	128	,	,	PUNCT
admet-2756	1	129	usa	usa	PROPN
admet-2756	1	130	corresponding	corresponding	PROPN
admet-2756	1	131	author	author	NOUN
admet-2756	1	132	:	:	PUNCT
admet-2756	1	133	e	e	NOUN
admet-2756	1	134	-	-	NOUN
admet-2756	1	135	mail	mail	NOUN
admet-2756	1	136	:	:	PUNCT
admet-2756	1	137	*	*	PUNCT
admet-2756	1	138	fganji@modares.ac.ir	fganji@modares.ac.ir	NOUN
admet-2756	1	139	received	receive	VERB
admet-2756	1	140	:	:	PUNCT
admet-2756	1	141	april	april	PROPN
admet-2756	1	142	6	6	NUM
admet-2756	1	143	,	,	PUNCT
admet-2756	1	144	2025	2025	NUM
admet-2756	1	145	;	;	PUNCT
admet-2756	1	146	revised	revise	VERB
admet-2756	1	147	:	:	PUNCT
admet-2756	1	148	june	june	PROPN
admet-2756	1	149	5	5	NUM
admet-2756	1	150	,	,	PUNCT
admet-2756	1	151	2025	2025	NUM
admet-2756	1	152	;	;	PUNCT
admet-2756	1	153	published	publish	VERB
admet-2756	1	154	:	:	PUNCT
admet-2756	1	155	june	june	PROPN
admet-2756	1	156	8	8	NUM
admet-2756	1	157	,	,	PUNCT
admet-2756	1	158	2025	2025	NUM
admet-2756	1	159	abstract	abstract	ADJ
admet-2756	1	160	background	background	NOUN
admet-2756	1	161	and	and	CCONJ
admet-2756	1	162	purpose	purpose	NOUN
admet-2756	1	163	:	:	PUNCT
admet-2756	1	164	bisphosphonates	bisphosphonate	NOUN
admet-2756	1	165	(	(	PUNCT
admet-2756	1	166	bps	bps	NOUN
admet-2756	1	167	)	)	PUNCT
admet-2756	1	168	are	be	AUX
admet-2756	1	169	well	well	ADV
admet-2756	1	170	-	-	PUNCT
admet-2756	1	171	known	know	VERB
admet-2756	1	172	for	for	ADP
admet-2756	1	173	their	their	PRON
admet-2756	1	174	strong	strong	ADJ
admet-2756	1	175	affinity	affinity	NOUN
admet-2756	1	176	toward	toward	ADP
admet-2756	1	177	bone	bone	NOUN
admet-2756	1	178	mineral	mineral	NOUN
admet-2756	1	179	matrices	matrix	NOUN
admet-2756	1	180	and	and	CCONJ
admet-2756	1	181	are	be	AUX
admet-2756	1	182	widely	widely	ADV
admet-2756	1	183	used	use	VERB
admet-2756	1	184	to	to	PART
admet-2756	1	185	inhibit	inhibit	VERB
admet-2756	1	186	excessive	excessive	ADJ
admet-2756	1	187	osteoclast	osteoclast	ADJ
admet-2756	1	188	activity	activity	NOUN
admet-2756	1	189	associated	associate	VERB
admet-2756	1	190	with	with	ADP
admet-2756	1	191	various	various	ADJ
admet-2756	1	192	bone	bone	NOUN
admet-2756	1	193	disorders	disorder	NOUN
admet-2756	1	194	.	.	PUNCT
admet-2756	2	1	beyond	beyond	ADP
admet-2756	2	2	their	their	PRON
admet-2756	2	3	clinical	clinical	ADJ
admet-2756	2	4	use	use	NOUN
admet-2756	2	5	,	,	PUNCT
admet-2756	2	6	their	their	PRON
admet-2756	2	7	unique	unique	ADJ
admet-2756	2	8	bone	bone	NOUN
admet-2756	2	9	-	-	PUNCT
admet-2756	2	10	targeting	target	VERB
admet-2756	2	11	capability	capability	NOUN
admet-2756	2	12	has	have	AUX
admet-2756	2	13	positioned	position	VERB
admet-2756	2	14	them	they	PRON
admet-2756	2	15	as	as	ADP
admet-2756	2	16	promising	promise	VERB
admet-2756	2	17	ligands	ligand	NOUN
admet-2756	2	18	for	for	ADP
admet-2756	2	19	drug	drug	NOUN
admet-2756	2	20	delivery	delivery	NOUN
admet-2756	2	21	systems	system	NOUN
admet-2756	2	22	aimed	aim	VERB
admet-2756	2	23	at	at	ADP
admet-2756	2	24	treating	treat	VERB
admet-2756	2	25	bone	bone	NOUN
admet-2756	2	26	-	-	PUNCT
admet-2756	2	27	related	relate	VERB
admet-2756	2	28	cancers	cancer	NOUN
admet-2756	2	29	.	.	PUNCT
admet-2756	3	1	approach	approach	NOUN
admet-2756	3	2	:	:	PUNCT
admet-2756	3	3	the	the	DET
admet-2756	3	4	review	review	NOUN
admet-2756	3	5	analyses	analyse	VERB
admet-2756	3	6	published	publish	VERB
admet-2756	3	7	studies	study	NOUN
admet-2756	3	8	on	on	ADP
admet-2756	3	9	bp	bp	NOUN
admet-2756	3	10	-	-	PUNCT
admet-2756	3	11	functionalized	functionalize	VERB
admet-2756	3	12	drug	drug	NOUN
admet-2756	3	13	delivery	delivery	NOUN
admet-2756	3	14	systems	system	NOUN
admet-2756	3	15	,	,	PUNCT
admet-2756	3	16	including	include	VERB
admet-2756	3	17	direct	direct	ADJ
admet-2756	3	18	drug	drug	NOUN
admet-2756	3	19	conjugates	conjugate	NOUN
admet-2756	3	20	,	,	PUNCT
admet-2756	3	21	calciumbased	calciumbased	ADJ
admet-2756	3	22	nanomaterials	nanomaterial	NOUN
admet-2756	3	23	,	,	PUNCT
admet-2756	3	24	carbon	carbon	NOUN
admet-2756	3	25	-	-	PUNCT
admet-2756	3	26	based	base	VERB
admet-2756	3	27	nanostructures	nanostructure	NOUN
admet-2756	3	28	,	,	PUNCT
admet-2756	3	29	and	and	CCONJ
admet-2756	3	30	self	self	NOUN
admet-2756	3	31	-	-	PUNCT
admet-2756	3	32	assembling	assemble	VERB
admet-2756	3	33	systems	system	NOUN
admet-2756	3	34	such	such	ADJ
admet-2756	3	35	as	as	ADP
admet-2756	3	36	micelles	micelle	NOUN
admet-2756	3	37	and	and	CCONJ
admet-2756	3	38	liposomes	liposome	NOUN
admet-2756	3	39	.	.	PUNCT
admet-2756	4	1	in	in	ADP
admet-2756	4	2	vitro	vitro	X
admet-2756	4	3	assays	assay	NOUN
admet-2756	4	4	(	(	PUNCT
admet-2756	4	5	e.g.	e.g.	ADV
admet-2756	4	6	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	4	7	binding	bind	VERB
admet-2756	4	8	,	,	PUNCT
admet-2756	4	9	cell	cell	NOUN
admet-2756	4	10	viability	viability	NOUN
admet-2756	4	11	)	)	PUNCT
admet-2756	4	12	and	and	CCONJ
admet-2756	4	13	in	in	ADP
admet-2756	4	14	vivo	vivo	ADJ
admet-2756	4	15	biodistribution	biodistribution	NOUN
admet-2756	4	16	studies	study	NOUN
admet-2756	4	17	are	be	AUX
admet-2756	4	18	discussed	discuss	VERB
admet-2756	4	19	to	to	PART
admet-2756	4	20	evaluate	evaluate	VERB
admet-2756	4	21	targeting	target	VERB
admet-2756	4	22	efficiency	efficiency	NOUN
admet-2756	4	23	and	and	CCONJ
admet-2756	4	24	therapeutic	therapeutic	ADJ
admet-2756	4	25	outcomes	outcome	NOUN
admet-2756	4	26	.	.	PUNCT
admet-2756	5	1	the	the	DET
admet-2756	5	2	impact	impact	NOUN
admet-2756	5	3	of	of	ADP
admet-2756	5	4	bp	bp	PROPN
admet-2756	5	5	structure	structure	NOUN
admet-2756	5	6	,	,	PUNCT
admet-2756	5	7	linker	linker	NOUN
admet-2756	5	8	chemistry	chemistry	NOUN
admet-2756	5	9	,	,	PUNCT
admet-2756	5	10	and	and	CCONJ
admet-2756	5	11	carrier	carrier	NOUN
admet-2756	5	12	material	material	NOUN
admet-2756	5	13	on	on	ADP
admet-2756	5	14	drug	drug	NOUN
admet-2756	5	15	release	release	NOUN
admet-2756	5	16	and	and	CCONJ
admet-2756	5	17	bone	bone	NOUN
admet-2756	5	18	accumulation	accumulation	NOUN
admet-2756	5	19	is	be	AUX
admet-2756	5	20	examined	examine	VERB
admet-2756	5	21	.	.	PUNCT
admet-2756	6	1	key	key	ADJ
admet-2756	6	2	results	result	NOUN
admet-2756	6	3	:	:	PUNCT
admet-2756	6	4	bpfunctionalized	bpfunctionalized	ADJ
admet-2756	6	5	systems	system	NOUN
admet-2756	6	6	consistently	consistently	ADV
admet-2756	6	7	demonstrate	demonstrate	VERB
admet-2756	6	8	improved	improved	ADJ
admet-2756	6	9	bone	bone	NOUN
admet-2756	6	10	targeting	target	VERB
admet-2756	6	11	and	and	CCONJ
admet-2756	6	12	enhanced	enhance	VERB
admet-2756	6	13	drug	drug	NOUN
admet-2756	6	14	accumulation	accumulation	NOUN
admet-2756	6	15	at	at	ADP
admet-2756	6	16	tumour	tumour	NOUN
admet-2756	6	17	sites	site	NOUN
admet-2756	6	18	compared	compare	VERB
admet-2756	6	19	to	to	ADP
admet-2756	6	20	non	non	ADJ
admet-2756	6	21	-	-	ADJ
admet-2756	6	22	targeted	targeted	ADJ
admet-2756	6	23	approaches	approach	NOUN
admet-2756	6	24	.	.	PUNCT
admet-2756	7	1	both	both	PRON
admet-2756	7	2	direct	direct	ADJ
admet-2756	7	3	conjugates	conjugate	NOUN
admet-2756	7	4	and	and	CCONJ
admet-2756	7	5	nanocarrier	nanocarrier	NOUN
admet-2756	7	6	-	-	PUNCT
admet-2756	7	7	based	base	VERB
admet-2756	7	8	systems	system	NOUN
admet-2756	7	9	show	show	VERB
admet-2756	7	10	promising	promising	ADJ
admet-2756	7	11	results	result	NOUN
admet-2756	7	12	,	,	PUNCT
admet-2756	7	13	with	with	ADP
admet-2756	7	14	some	some	DET
admet-2756	7	15	formulations	formulation	NOUN
admet-2756	7	16	offering	offer	VERB
admet-2756	7	17	controlled	control	VERB
admet-2756	7	18	drug	drug	NOUN
admet-2756	7	19	release	release	NOUN
admet-2756	7	20	and	and	CCONJ
admet-2756	7	21	reduced	reduce	VERB
admet-2756	7	22	systemic	systemic	ADJ
admet-2756	7	23	toxicity	toxicity	NOUN
admet-2756	7	24	.	.	PUNCT
admet-2756	8	1	despite	despite	SCONJ
admet-2756	8	2	these	these	DET
admet-2756	8	3	advances	advance	NOUN
admet-2756	8	4	,	,	PUNCT
admet-2756	8	5	certain	certain	ADJ
admet-2756	8	6	challenges	challenge	NOUN
admet-2756	8	7	such	such	ADJ
admet-2756	8	8	as	as	ADP
admet-2756	8	9	burst	burst	ADJ
admet-2756	8	10	release	release	NOUN
admet-2756	8	11	and	and	CCONJ
admet-2756	8	12	incomplete	incomplete	ADJ
admet-2756	8	13	clinical	clinical	ADJ
admet-2756	8	14	validation	validation	NOUN
admet-2756	8	15	remain	remain	VERB
admet-2756	8	16	.	.	PUNCT
admet-2756	9	1	conclusion	conclusion	NOUN
admet-2756	9	2	:	:	PUNCT
admet-2756	9	3	this	this	DET
admet-2756	9	4	review	review	NOUN
admet-2756	9	5	highlights	highlight	VERB
admet-2756	9	6	the	the	DET
admet-2756	9	7	significant	significant	ADJ
admet-2756	9	8	progress	progress	NOUN
admet-2756	9	9	in	in	ADP
admet-2756	9	10	bp	bp	PROPN
admet-2756	9	11	-	-	PUNCT
admet-2756	9	12	based	base	VERB
admet-2756	9	13	drug	drug	NOUN
admet-2756	9	14	delivery	delivery	NOUN
admet-2756	9	15	platforms	platform	NOUN
admet-2756	9	16	for	for	ADP
admet-2756	9	17	bone	bone	NOUN
admet-2756	9	18	cancer	cancer	NOUN
admet-2756	9	19	therapy	therapy	NOUN
admet-2756	9	20	,	,	PUNCT
admet-2756	9	21	demonstrating	demonstrate	VERB
admet-2756	9	22	their	their	PRON
admet-2756	9	23	potential	potential	NOUN
admet-2756	9	24	to	to	PART
admet-2756	9	25	concentrate	concentrate	VERB
admet-2756	9	26	therapeutic	therapeutic	ADJ
admet-2756	9	27	agents	agent	NOUN
admet-2756	9	28	at	at	ADP
admet-2756	9	29	bone	bone	NOUN
admet-2756	9	30	tumour	tumour	NOUN
admet-2756	9	31	sites	site	NOUN
admet-2756	9	32	while	while	SCONJ
admet-2756	9	33	minimizing	minimize	VERB
admet-2756	9	34	off	off	ADP
admet-2756	9	35	-	-	PUNCT
admet-2756	9	36	target	target	NOUN
admet-2756	9	37	effects	effect	NOUN
admet-2756	9	38	.	.	PUNCT
admet-2756	10	1	the	the	DET
admet-2756	10	2	integration	integration	NOUN
admet-2756	10	3	of	of	ADP
admet-2756	10	4	nanotechnology	nanotechnology	NOUN
admet-2756	10	5	with	with	ADP
admet-2756	10	6	bp	bp	PROPN
admet-2756	10	7	targeting	target	VERB
admet-2756	10	8	offers	offer	VERB
admet-2756	10	9	new	new	ADJ
admet-2756	10	10	opportunities	opportunity	NOUN
admet-2756	10	11	for	for	ADP
admet-2756	10	12	treating	treat	VERB
admet-2756	10	13	bone	bone	NOUN
admet-2756	10	14	metastases	metastasis	NOUN
admet-2756	10	15	and	and	CCONJ
admet-2756	10	16	primary	primary	ADJ
admet-2756	10	17	bone	bone	NOUN
admet-2756	10	18	tumours	tumours	NOUN
admet-2756	10	19	.	.	PUNCT
admet-2756	11	1	however	however	ADV
admet-2756	11	2	,	,	PUNCT
admet-2756	11	3	further	further	ADJ
admet-2756	11	4	research	research	NOUN
admet-2756	11	5	is	be	AUX
admet-2756	11	6	needed	need	VERB
admet-2756	11	7	to	to	PART
admet-2756	11	8	address	address	VERB
admet-2756	11	9	current	current	ADJ
admet-2756	11	10	limitations	limitation	NOUN
admet-2756	11	11	and	and	CCONJ
admet-2756	11	12	translate	translate	VERB
admet-2756	11	13	these	these	DET
admet-2756	11	14	findings	finding	NOUN
admet-2756	11	15	into	into	ADP
admet-2756	11	16	clinical	clinical	ADJ
admet-2756	11	17	practice	practice	NOUN
admet-2756	11	18	.	.	PUNCT
admet-2756	12	1	©	©	X
admet-2756	12	2	2025	2025	NUM
admet-2756	12	3	by	by	ADP
admet-2756	12	4	the	the	DET
admet-2756	12	5	authors	author	NOUN
admet-2756	12	6	.	.	PUNCT
admet-2756	13	1	this	this	DET
admet-2756	13	2	article	article	NOUN
admet-2756	13	3	is	be	AUX
admet-2756	13	4	an	an	DET
admet-2756	13	5	open	open	ADJ
admet-2756	13	6	-	-	PUNCT
admet-2756	13	7	access	access	NOUN
admet-2756	13	8	article	article	NOUN
admet-2756	13	9	distributed	distribute	VERB
admet-2756	13	10	under	under	ADP
admet-2756	13	11	the	the	DET
admet-2756	13	12	terms	term	NOUN
admet-2756	13	13	and	and	CCONJ
admet-2756	13	14	conditions	condition	NOUN
admet-2756	13	15	of	of	ADP
admet-2756	13	16	the	the	DET
admet-2756	13	17	creative	creative	ADJ
admet-2756	13	18	commons	common	NOUN
admet-2756	13	19	attribution	attribution	NOUN
admet-2756	13	20	license	license	NOUN
admet-2756	13	21	(	(	PUNCT
admet-2756	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2756	13	23	)	)	PUNCT
admet-2756	13	24	.	.	PUNCT
admet-2756	14	1	keywords	keyword	VERB
admet-2756	14	2	nanomedicine	nanomedicine	NOUN
admet-2756	14	3	;	;	PUNCT
admet-2756	14	4	tumour	tumour	NOUN
admet-2756	14	5	;	;	PUNCT
admet-2756	14	6	targeted	target	VERB
admet-2756	14	7	drug	drug	NOUN
admet-2756	14	8	delivery	delivery	NOUN
admet-2756	14	9	;	;	PUNCT
admet-2756	14	10	nanomaterials	nanomaterial	NOUN
admet-2756	14	11	introduction	introduction	NOUN
admet-2756	14	12	bisphosphonates	bisphosphonate	NOUN
admet-2756	14	13	(	(	PUNCT
admet-2756	14	14	bps	bps	NOUN
admet-2756	14	15	)	)	PUNCT
admet-2756	14	16	are	be	AUX
admet-2756	14	17	a	a	DET
admet-2756	14	18	class	class	NOUN
admet-2756	14	19	of	of	ADP
admet-2756	14	20	compounds	compound	NOUN
admet-2756	14	21	with	with	ADP
admet-2756	14	22	high	high	ADJ
admet-2756	14	23	affinity	affinity	NOUN
admet-2756	14	24	to	to	ADP
admet-2756	14	25	bone	bone	NOUN
admet-2756	14	26	mineral	mineral	NOUN
admet-2756	14	27	matrix	matrix	NOUN
admet-2756	14	28	and	and	CCONJ
admet-2756	14	29	the	the	DET
admet-2756	14	30	ability	ability	NOUN
admet-2756	14	31	to	to	PART
admet-2756	14	32	inhibit	inhibit	VERB
admet-2756	14	33	accelerated	accelerate	VERB
admet-2756	14	34	bone	bone	NOUN
admet-2756	14	35	resorption	resorption	NOUN
admet-2756	14	36	[	[	X
admet-2756	14	37	1,2	1,2	NUM
admet-2756	14	38	]	]	PUNCT
admet-2756	14	39	.	.	PUNCT
admet-2756	15	1	the	the	DET
admet-2756	15	2	extracellular	extracellular	ADJ
admet-2756	15	3	matrix	matrix	NOUN
admet-2756	15	4	of	of	ADP
admet-2756	15	5	bone	bone	NOUN
admet-2756	15	6	is	be	AUX
admet-2756	15	7	composed	compose	VERB
admet-2756	15	8	of	of	ADP
admet-2756	15	9	organic	organic	ADJ
admet-2756	15	10	and	and	CCONJ
admet-2756	15	11	inorganic	inorganic	ADJ
admet-2756	15	12	sections	section	NOUN
admet-2756	15	13	.	.	PUNCT
admet-2756	16	1	while	while	SCONJ
admet-2756	16	2	the	the	DET
admet-2756	16	3	organic	organic	ADJ
admet-2756	16	4	portion	portion	NOUN
admet-2756	16	5	is	be	AUX
admet-2756	16	6	rich	rich	ADJ
admet-2756	16	7	in	in	ADP
admet-2756	16	8	filamentous	filamentous	ADJ
admet-2756	16	9	proteins	protein	NOUN
admet-2756	16	10	and	and	CCONJ
admet-2756	16	11	glycosaminoglycans	glycosaminoglycan	NOUN
admet-2756	16	12	,	,	PUNCT
admet-2756	16	13	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	16	14	(	(	PUNCT
admet-2756	16	15	hap	hap	NOUN
admet-2756	16	16	)	)	PUNCT
admet-2756	16	17	crystals	crystal	NOUN
admet-2756	16	18	account	account	VERB
admet-2756	16	19	for	for	ADP
admet-2756	16	20	the	the	DET
admet-2756	16	21	majority	majority	NOUN
admet-2756	16	22	of	of	ADP
admet-2756	16	23	the	the	DET
admet-2756	16	24	inorganic	inorganic	ADJ
admet-2756	16	25	portion	portion	NOUN
admet-2756	16	26	[	[	X
admet-2756	16	27	3	3	NUM
admet-2756	16	28	]	]	PUNCT
admet-2756	16	29	.	.	PUNCT
admet-2756	17	1	these	these	DET
admet-2756	17	2	crystals	crystal	NOUN
admet-2756	17	3	,	,	PUNCT
admet-2756	17	4	having	have	VERB
admet-2756	17	5	large	large	ADJ
admet-2756	17	6	amounts	amount	NOUN
admet-2756	17	7	of	of	ADP
admet-2756	17	8	calcium	calcium	NOUN
admet-2756	17	9	ions	ion	NOUN
admet-2756	17	10	in	in	ADP
admet-2756	17	11	their	their	PRON
admet-2756	17	12	structure	structure	NOUN
admet-2756	17	13	,	,	PUNCT
admet-2756	17	14	show	show	VERB
admet-2756	17	15	a	a	DET
admet-2756	17	16	high	high	ADJ
admet-2756	17	17	binding	bind	VERB
admet-2756	17	18	affinity	affinity	NOUN
admet-2756	17	19	for	for	ADP
admet-2756	17	20	bps	bps	NOUN
admet-2756	17	21	[	[	X
admet-2756	17	22	4	4	NUM
admet-2756	17	23	]	]	PUNCT
admet-2756	17	24	.	.	PUNCT
admet-2756	18	1	the	the	DET
admet-2756	18	2	structure	structure	NOUN
admet-2756	18	3	of	of	ADP
admet-2756	18	4	bps	bps	NOUN
admet-2756	18	5	is	be	AUX
admet-2756	18	6	characterized	characterize	VERB
admet-2756	18	7	by	by	ADP
admet-2756	18	8	a	a	DET
admet-2756	18	9	p	p	NOUN
admet-2756	18	10	=	=	NOUN
admet-2756	18	11	c	c	NOUN
admet-2756	18	12	=	=	NOUN
admet-2756	18	13	p	p	NOUN
admet-2756	18	14	backbone	backbone	NOUN
admet-2756	18	15	.	.	PUNCT
admet-2756	19	1	the	the	DET
admet-2756	19	2	central	central	ADJ
admet-2756	19	3	carbon	carbon	NOUN
admet-2756	19	4	atom	atom	NOUN
admet-2756	19	5	is	be	AUX
admet-2756	19	6	linked	link	VERB
admet-2756	19	7	to	to	ADP
admet-2756	19	8	two	two	NUM
admet-2756	19	9	phosphonate	phosphonate	ADJ
admet-2756	19	10	groups	group	NOUN
admet-2756	19	11	and	and	CCONJ
admet-2756	19	12	two	two	NUM
admet-2756	19	13	other	other	ADJ
admet-2756	19	14	groups	group	NOUN
admet-2756	19	15	referred	refer	VERB
admet-2756	19	16	to	to	ADP
admet-2756	19	17	as	as	ADP
admet-2756	19	18	r1	r1	NOUN
admet-2756	19	19	and	and	CCONJ
admet-2756	19	20	r2	r2	PROPN
admet-2756	19	21	.	.	PUNCT
admet-2756	20	1	figure	figure	NOUN
admet-2756	20	2	1	1	NUM
admet-2756	20	3	exhibits	exhibit	VERB
admet-2756	20	4	the	the	DET
admet-2756	20	5	general	general	ADJ
admet-2756	20	6	structure	structure	NOUN
admet-2756	20	7	and	and	CCONJ
admet-2756	20	8	action	action	NOUN
admet-2756	20	9	of	of	ADP
admet-2756	20	10	bps	bps	PROPN
admet-2756	20	11	.	.	PUNCT
admet-2756	21	1	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	PROPN
admet-2756	21	2	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	21	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2756	21	4	mailto:fganji@modares.ac.ir	mailto:fganji@modares.ac.ir	PROPN
admet-2756	21	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2756	21	6	m.	m.	PROPN
admet-2756	21	7	eshaghi	eshaghi	PROPN
admet-2756	21	8	et	et	PROPN
admet-2756	21	9	al	al	PROPN
admet-2756	21	10	.	.	PROPN
admet-2756	21	11	admet	admet	PROPN
admet-2756	21	12	&	&	CCONJ
admet-2756	21	13	dmpk	dmpk	PROPN
admet-2756	21	14	13(3	13(3	NUM
admet-2756	21	15	)	)	PUNCT
admet-2756	21	16	(	(	PUNCT
admet-2756	21	17	2025	2025	NUM
admet-2756	21	18	)	)	PUNCT
admet-2756	21	19	2756	2756	NUM
admet-2756	21	20	2	2	NUM
admet-2756	21	21	the	the	DET
admet-2756	21	22	identity	identity	NOUN
admet-2756	21	23	of	of	ADP
admet-2756	21	24	the	the	DET
admet-2756	21	25	r1	r1	PROPN
admet-2756	21	26	and	and	CCONJ
admet-2756	21	27	r2	r2	NOUN
admet-2756	21	28	groups	group	NOUN
admet-2756	21	29	differentiates	differentiate	NOUN
admet-2756	21	30	between	between	ADP
admet-2756	21	31	different	different	ADJ
admet-2756	21	32	bps	bps	NOUN
admet-2756	21	33	.	.	PUNCT
admet-2756	21	34	table	table	NOUN
admet-2756	21	35	1	1	NUM
admet-2756	21	36	introduces	introduce	NOUN
admet-2756	21	37	r1	r1	NOUN
admet-2756	21	38	and	and	CCONJ
admet-2756	21	39	r2	r2	NOUN
admet-2756	21	40	groups	group	NOUN
admet-2756	21	41	for	for	ADP
admet-2756	21	42	the	the	DET
admet-2756	21	43	most	most	ADV
admet-2756	21	44	common	common	ADJ
admet-2756	21	45	bps	bps	NOUN
admet-2756	21	46	.	.	PUNCT
admet-2756	22	1	these	these	DET
admet-2756	22	2	groups	group	NOUN
admet-2756	22	3	play	play	VERB
admet-2756	22	4	a	a	DET
admet-2756	22	5	major	major	ADJ
admet-2756	22	6	role	role	NOUN
admet-2756	22	7	in	in	ADP
admet-2756	22	8	the	the	DET
admet-2756	22	9	affinity	affinity	NOUN
admet-2756	22	10	of	of	ADP
admet-2756	22	11	bps	bps	NOUN
admet-2756	22	12	to	to	ADP
admet-2756	22	13	hap	hap	VERB
admet-2756	22	14	[	[	X
admet-2756	22	15	5	5	NUM
admet-2756	22	16	]	]	PUNCT
admet-2756	22	17	.	.	PUNCT
admet-2756	23	1	for	for	ADP
admet-2756	23	2	instance	instance	NOUN
admet-2756	23	3	,	,	PUNCT
admet-2756	23	4	the	the	DET
admet-2756	23	5	presence	presence	NOUN
admet-2756	23	6	of	of	ADP
admet-2756	23	7	an	an	DET
admet-2756	23	8	amine	amine	ADJ
admet-2756	23	9	group	group	NOUN
admet-2756	23	10	as	as	ADP
admet-2756	23	11	the	the	DET
admet-2756	23	12	r2	r2	PROPN
admet-2756	23	13	group	group	NOUN
admet-2756	23	14	of	of	ADP
admet-2756	23	15	alendronate	alendronate	PROPN
admet-2756	23	16	(	(	PUNCT
admet-2756	23	17	aln	aln	PROPN
admet-2756	23	18	)	)	PUNCT
admet-2756	23	19	results	result	NOUN
admet-2756	23	20	in	in	ADP
admet-2756	23	21	the	the	DET
admet-2756	23	22	formation	formation	NOUN
admet-2756	23	23	of	of	ADP
admet-2756	23	24	a	a	DET
admet-2756	23	25	hydrogen	hydrogen	NOUN
admet-2756	23	26	bond	bond	NOUN
admet-2756	23	27	with	with	ADP
admet-2756	23	28	hap	hap	NOUN
admet-2756	23	29	crystals	crystal	NOUN
admet-2756	23	30	,	,	PUNCT
admet-2756	23	31	which	which	PRON
admet-2756	23	32	extends	extend	VERB
admet-2756	23	33	bp	bp	PROPN
admet-2756	23	34	-	-	PUNCT
admet-2756	23	35	hap	hap	NOUN
admet-2756	23	36	interaction	interaction	NOUN
admet-2756	23	37	[	[	X
admet-2756	23	38	6	6	NUM
admet-2756	23	39	]	]	PUNCT
admet-2756	23	40	.	.	PUNCT
admet-2756	24	1	furthermore	furthermore	ADV
admet-2756	24	2	,	,	PUNCT
admet-2756	24	3	the	the	DET
admet-2756	24	4	two	two	NUM
admet-2756	24	5	oh	oh	INTJ
admet-2756	24	6	arms	arm	NOUN
admet-2756	24	7	of	of	ADP
admet-2756	24	8	each	each	DET
admet-2756	24	9	phosphonate	phosphonate	ADJ
admet-2756	24	10	group	group	NOUN
admet-2756	24	11	in	in	ADP
admet-2756	24	12	a	a	DET
admet-2756	24	13	bp	bp	PROPN
admet-2756	24	14	molecule	molecule	NOUN
admet-2756	24	15	form	form	NOUN
admet-2756	24	16	an	an	DET
admet-2756	24	17	ionic	ionic	ADJ
admet-2756	24	18	crosslinked	crosslinke	VERB
admet-2756	24	19	network	network	NOUN
admet-2756	24	20	with	with	ADP
admet-2756	24	21	a	a	DET
admet-2756	24	22	ca2	ca2	PROPN
admet-2756	24	23	+	+	NOUN
admet-2756	24	24	ion	ion	NOUN
admet-2756	24	25	in	in	ADP
admet-2756	24	26	the	the	DET
admet-2756	24	27	structure	structure	NOUN
admet-2756	24	28	of	of	ADP
admet-2756	24	29	hap	hap	NOUN
admet-2756	24	30	,	,	PUNCT
admet-2756	24	31	which	which	PRON
admet-2756	24	32	is	be	AUX
admet-2756	24	33	chiefly	chiefly	ADV
admet-2756	24	34	responsible	responsible	ADJ
admet-2756	24	35	for	for	ADP
admet-2756	24	36	the	the	DET
admet-2756	24	37	affinity	affinity	NOUN
admet-2756	24	38	of	of	ADP
admet-2756	24	39	bps	bps	NOUN
admet-2756	24	40	to	to	ADP
admet-2756	24	41	the	the	DET
admet-2756	24	42	mineral	mineral	NOUN
admet-2756	24	43	network	network	NOUN
admet-2756	24	44	[	[	X
admet-2756	24	45	7	7	NUM
admet-2756	24	46	]	]	PUNCT
admet-2756	24	47	.	.	PUNCT
admet-2756	25	1	with	with	ADP
admet-2756	25	2	the	the	DET
admet-2756	25	3	same	same	ADJ
admet-2756	25	4	logic	logic	NOUN
admet-2756	25	5	,	,	PUNCT
admet-2756	25	6	in	in	ADP
admet-2756	25	7	cases	case	NOUN
admet-2756	25	8	where	where	SCONJ
admet-2756	25	9	the	the	DET
admet-2756	25	10	r1	r1	PROPN
admet-2756	25	11	group	group	NOUN
admet-2756	25	12	is	be	AUX
admet-2756	25	13	a	a	DET
admet-2756	25	14	hydroxyl	hydroxyl	NOUN
admet-2756	25	15	,	,	PUNCT
admet-2756	25	16	ionic	ionic	ADJ
admet-2756	25	17	interaction	interaction	NOUN
admet-2756	25	18	with	with	ADP
admet-2756	25	19	ca2	ca2	PROPN
admet-2756	25	20	+	+	PROPN
admet-2756	25	21	ions	ion	NOUN
admet-2756	25	22	,	,	PUNCT
admet-2756	25	23	and	and	CCONJ
admet-2756	25	24	consequently	consequently	ADV
admet-2756	25	25	,	,	PUNCT
admet-2756	25	26	bp	bp	PROPN
admet-2756	25	27	affinity	affinity	NOUN
admet-2756	25	28	to	to	ADP
admet-2756	25	29	hap	hap	PROPN
admet-2756	25	30	is	be	AUX
admet-2756	25	31	further	far	ADV
admet-2756	25	32	increased	increase	VERB
admet-2756	25	33	[	[	X
admet-2756	25	34	8	8	NUM
admet-2756	25	35	]	]	PUNCT
admet-2756	25	36	.	.	PUNCT
admet-2756	26	1	figure	figure	NOUN
admet-2756	26	2	1	1	NUM
admet-2756	26	3	.	.	PUNCT
admet-2756	27	1	(	(	PUNCT
admet-2756	27	2	a	a	X
admet-2756	27	3	)	)	PUNCT
admet-2756	27	4	general	general	ADJ
admet-2756	27	5	chemical	chemical	NOUN
admet-2756	27	6	structure	structure	NOUN
admet-2756	27	7	of	of	ADP
admet-2756	27	8	bps	bps	NOUN
admet-2756	27	9	;	;	PUNCT
admet-2756	27	10	(	(	PUNCT
admet-2756	27	11	b	b	X
admet-2756	27	12	)	)	PUNCT
admet-2756	27	13	demonstration	demonstration	NOUN
admet-2756	27	14	of	of	ADP
admet-2756	27	15	bps	bps	NOUN
admet-2756	27	16	affinity	affinity	NOUN
admet-2756	27	17	for	for	ADP
admet-2756	27	18	calcium	calcium	NOUN
admet-2756	27	19	ions	ion	NOUN
admet-2756	27	20	table	table	NOUN
admet-2756	27	21	1	1	NUM
admet-2756	27	22	.	.	PUNCT
admet-2756	27	23	chemical	chemical	ADJ
admet-2756	27	24	structure	structure	NOUN
admet-2756	27	25	of	of	ADP
admet-2756	27	26	commonly	commonly	ADV
admet-2756	27	27	used	use	VERB
admet-2756	27	28	bps	bps	NOUN
admet-2756	27	29	name	name	NOUN
admet-2756	27	30	r1	r1	PROPN
admet-2756	27	31	group	group	PROPN
admet-2756	27	32	r2	r2	PROPN
admet-2756	27	33	group	group	PROPN
admet-2756	27	34	alendronate	alendronate	NOUN
admet-2756	28	1	oh	oh	INTJ
admet-2756	28	2	zoledronate	zoledronate	NOUN
admet-2756	29	1	oh	oh	INTJ
admet-2756	29	2	pamidronate	pamidronate	ADJ
admet-2756	29	3	oh	oh	INTJ
admet-2756	29	4	risedronate	risedronate	NOUN
admet-2756	29	5	oh	oh	INTJ
admet-2756	29	6	clodronate	clodronate	NOUN
admet-2756	29	7	cl	cl	NOUN
admet-2756	29	8	cl	cl	NOUN
admet-2756	29	9	ibandronate	ibandronate	NOUN
admet-2756	30	1	oh	oh	INTJ
admet-2756	30	2	etidronate	etidronate	ADV
admet-2756	31	1	oh	oh	INTJ
admet-2756	31	2	ch3	ch3	PROPN
admet-2756	31	3	therefore	therefore	ADV
admet-2756	31	4	,	,	PUNCT
admet-2756	31	5	bps	bps	NOUN
admet-2756	31	6	can	can	AUX
admet-2756	31	7	be	be	AUX
admet-2756	31	8	used	use	VERB
admet-2756	31	9	to	to	PART
admet-2756	31	10	target	target	VERB
admet-2756	31	11	ligands	ligand	NOUN
admet-2756	31	12	and	and	CCONJ
admet-2756	31	13	deliver	deliver	VERB
admet-2756	31	14	drugs	drug	NOUN
admet-2756	31	15	to	to	ADP
admet-2756	31	16	the	the	DET
admet-2756	31	17	bone	bone	NOUN
admet-2756	31	18	microenvironment	microenvironment	NOUN
admet-2756	31	19	through	through	ADP
admet-2756	31	20	their	their	PRON
admet-2756	31	21	binding	binding	NOUN
admet-2756	31	22	with	with	ADP
admet-2756	31	23	the	the	DET
admet-2756	31	24	hap	hap	NOUN
admet-2756	31	25	of	of	ADP
admet-2756	31	26	bone	bone	NOUN
admet-2756	31	27	tissue	tissue	NOUN
admet-2756	31	28	.	.	PUNCT
admet-2756	32	1	given	give	VERB
admet-2756	32	2	these	these	DET
admet-2756	32	3	attributes	attribute	NOUN
admet-2756	32	4	,	,	PUNCT
admet-2756	32	5	they	they	PRON
admet-2756	32	6	have	have	AUX
admet-2756	32	7	been	be	AUX
admet-2756	32	8	recognized	recognize	VERB
admet-2756	32	9	as	as	ADP
admet-2756	32	10	valuable	valuable	ADJ
admet-2756	32	11	therapeutic	therapeutic	ADJ
admet-2756	32	12	agents	agent	NOUN
admet-2756	32	13	for	for	ADP
admet-2756	32	14	bone	bone	NOUN
admet-2756	32	15	disorders	disorder	NOUN
admet-2756	32	16	characterized	characterize	VERB
admet-2756	32	17	by	by	ADP
admet-2756	32	18	abnormal	abnormal	ADJ
admet-2756	32	19	activity	activity	NOUN
admet-2756	32	20	of	of	ADP
admet-2756	32	21	osteoclasts	osteoclast	NOUN
admet-2756	32	22	.	.	PUNCT
admet-2756	33	1	a	a	DET
admet-2756	33	2	primary	primary	ADJ
admet-2756	33	3	example	example	NOUN
admet-2756	33	4	of	of	ADP
admet-2756	33	5	such	such	ADJ
admet-2756	33	6	disorders	disorder	NOUN
admet-2756	33	7	would	would	AUX
admet-2756	33	8	be	be	AUX
admet-2756	33	9	osteoporosis	osteoporosis	NOUN
admet-2756	33	10	[	[	X
admet-2756	33	11	9,10	9,10	NUM
admet-2756	33	12	]	]	X
admet-2756	33	13	.	.	PUNCT
admet-2756	34	1	when	when	SCONJ
admet-2756	34	2	the	the	DET
admet-2756	34	3	balance	balance	NOUN
admet-2756	34	4	between	between	ADP
admet-2756	34	5	osteoclast	osteoclast	ADJ
admet-2756	34	6	activity	activity	NOUN
admet-2756	34	7	and	and	CCONJ
admet-2756	34	8	osteoblast	osteoblast	ADJ
admet-2756	34	9	activity	activity	NOUN
admet-2756	34	10	is	be	AUX
admet-2756	34	11	shifted	shift	VERB
admet-2756	34	12	to	to	ADP
admet-2756	34	13	the	the	DET
admet-2756	34	14	benefit	benefit	NOUN
admet-2756	34	15	of	of	ADP
admet-2756	34	16	the	the	DET
admet-2756	34	17	former	former	ADJ
admet-2756	34	18	,	,	PUNCT
admet-2756	34	19	bone	bone	NOUN
admet-2756	34	20	resorption	resorption	NOUN
admet-2756	34	21	increases	increase	NOUN
admet-2756	34	22	and	and	CCONJ
admet-2756	34	23	bone	bone	NOUN
admet-2756	34	24	tissue	tissue	NOUN
admet-2756	34	25	density	density	NOUN
admet-2756	34	26	decreases	decrease	VERB
admet-2756	34	27	,	,	PUNCT
admet-2756	34	28	which	which	PRON
admet-2756	34	29	leads	lead	VERB
admet-2756	34	30	to	to	ADP
admet-2756	34	31	the	the	DET
admet-2756	34	32	risk	risk	NOUN
admet-2756	34	33	of	of	ADP
admet-2756	34	34	pathological	pathological	ADJ
admet-2756	34	35	fractures	fracture	NOUN
admet-2756	34	36	[	[	X
admet-2756	34	37	11	11	NUM
admet-2756	34	38	]	]	PUNCT
admet-2756	34	39	.	.	PUNCT
admet-2756	35	1	studies	study	NOUN
admet-2756	35	2	on	on	ADP
admet-2756	35	3	bp	bp	PROPN
admet-2756	35	4	pharmacodynamics	pharmacodynamic	NOUN
admet-2756	35	5	have	have	AUX
admet-2756	35	6	revealed	reveal	VERB
admet-2756	35	7	how	how	SCONJ
admet-2756	35	8	they	they	PRON
admet-2756	35	9	ameliorate	ameliorate	VERB
admet-2756	35	10	this	this	DET
admet-2756	35	11	condition	condition	NOUN
admet-2756	35	12	.	.	PUNCT
admet-2756	36	1	initially	initially	ADV
admet-2756	36	2	,	,	PUNCT
admet-2756	36	3	bps	bps	NOUN
admet-2756	36	4	selectively	selectively	ADV
admet-2756	36	5	accumulate	accumulate	VERB
admet-2756	36	6	in	in	ADP
admet-2756	36	7	the	the	DET
admet-2756	36	8	bone	bone	NOUN
admet-2756	36	9	mineral	mineral	NOUN
admet-2756	36	10	network	network	NOUN
admet-2756	36	11	.	.	PUNCT
admet-2756	37	1	the	the	DET
admet-2756	37	2	acidic	acidic	ADJ
admet-2756	37	3	medium	medium	NOUN
admet-2756	37	4	of	of	ADP
admet-2756	37	5	bone	bone	NOUN
admet-2756	37	6	tissue	tissue	NOUN
admet-2756	37	7	with	with	ADP
admet-2756	37	8	extra	extra	ADJ
admet-2756	37	9	-	-	ADJ
admet-2756	37	10	normally	normally	ADV
admet-2756	37	11	active	active	ADJ
admet-2756	37	12	osteoclasts	osteoclast	NOUN
admet-2756	37	13	causes	cause	VERB
admet-2756	37	14	the	the	DET
admet-2756	37	15	removal	removal	NOUN
admet-2756	37	16	of	of	ADP
admet-2756	37	17	bps	bps	NOUN
admet-2756	37	18	from	from	ADP
admet-2756	37	19	the	the	DET
admet-2756	37	20	mineral	mineral	NOUN
admet-2756	37	21	admet	admet	PROPN
admet-2756	37	22	&	&	CCONJ
admet-2756	37	23	dmpk	dmpk	PROPN
admet-2756	37	24	13(3	13(3	NUM
admet-2756	37	25	)	)	PUNCT
admet-2756	37	26	(	(	PUNCT
admet-2756	37	27	2025	2025	NUM
admet-2756	37	28	)	)	PUNCT
admet-2756	37	29	2756	2756	NUM
admet-2756	37	30	bisphosphonates	bisphosphonate	NOUN
admet-2756	37	31	for	for	ADP
admet-2756	37	32	bone	bone	NOUN
admet-2756	37	33	cancer	cancer	NOUN
admet-2756	37	34	therapy	therapy	NOUN
admet-2756	37	35	doi	doi	NOUN
admet-2756	37	36	:	:	PUNCT
admet-2756	37	37	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	37	38	3	3	NUM
admet-2756	37	39	network	network	NOUN
admet-2756	37	40	.	.	PUNCT
admet-2756	38	1	the	the	DET
admet-2756	38	2	bps	bps	NOUN
admet-2756	38	3	molecules	molecule	NOUN
admet-2756	38	4	are	be	AUX
admet-2756	38	5	then	then	ADV
admet-2756	38	6	endocytosed	endocytose	VERB
admet-2756	38	7	by	by	ADP
admet-2756	38	8	osteoclast	osteoclast	ADJ
admet-2756	38	9	cells	cell	NOUN
admet-2756	38	10	,	,	PUNCT
admet-2756	38	11	which	which	PRON
admet-2756	38	12	are	be	AUX
admet-2756	38	13	metabolized	metabolize	VERB
admet-2756	38	14	into	into	ADP
admet-2756	38	15	a	a	DET
admet-2756	38	16	toxic	toxic	ADJ
admet-2756	38	17	metabolite	metabolite	NOUN
admet-2756	38	18	,	,	PUNCT
admet-2756	38	19	which	which	PRON
admet-2756	38	20	triggers	trigger	VERB
admet-2756	38	21	cell	cell	NOUN
admet-2756	38	22	apoptosis	apoptosis	NOUN
admet-2756	38	23	[	[	X
admet-2756	38	24	12	12	NUM
admet-2756	38	25	]	]	PUNCT
admet-2756	38	26	.	.	PUNCT
admet-2756	39	1	currently	currently	ADV
admet-2756	39	2	,	,	PUNCT
admet-2756	39	3	there	there	PRON
admet-2756	39	4	are	be	VERB
admet-2756	39	5	many	many	ADJ
admet-2756	39	6	bisphosphonate	bisphosphonate	NOUN
admet-2756	39	7	-	-	PUNCT
admet-2756	39	8	based	base	VERB
admet-2756	39	9	comercialized	comercialize	VERB
admet-2756	39	10	drugs	drug	NOUN
admet-2756	39	11	in	in	ADP
admet-2756	39	12	the	the	DET
admet-2756	39	13	market	market	NOUN
admet-2756	39	14	for	for	ADP
admet-2756	39	15	different	different	ADJ
admet-2756	39	16	bone	bone	NOUN
admet-2756	39	17	disorders	disorder	NOUN
admet-2756	39	18	(	(	PUNCT
admet-2756	39	19	table	table	NOUN
admet-2756	39	20	2	2	NUM
admet-2756	39	21	)	)	PUNCT
admet-2756	39	22	.	.	PUNCT
admet-2756	40	1	table	table	NOUN
admet-2756	40	2	2	2	NUM
admet-2756	40	3	.	.	X
admet-2756	40	4	list	list	NOUN
admet-2756	40	5	of	of	ADP
admet-2756	40	6	commercialized	commercialize	VERB
admet-2756	40	7	bps	bps	NOUN
admet-2756	40	8	for	for	ADP
admet-2756	40	9	bone	bone	NOUN
admet-2756	40	10	disorders	disorder	NOUN
admet-2756	40	11	brand	brand	NOUN
admet-2756	40	12	name	name	VERB
admet-2756	40	13	active	active	ADJ
admet-2756	40	14	ingredient	ingredient	NOUN
admet-2756	40	15	application	application	NOUN
admet-2756	40	16	fda	fda	PROPN
admet-2756	40	17	approval	approval	PROPN
admet-2756	40	18	year	year	NOUN
admet-2756	40	19	company	company	NOUN
admet-2756	40	20	didronel	didronel	PROPN
admet-2756	40	21	etidronate	etidronate	PROPN
admet-2756	40	22	paget	paget	PROPN
admet-2756	40	23	’s	’s	PART
admet-2756	40	24	disease	disease	NOUN
admet-2756	40	25	,	,	PUNCT
admet-2756	40	26	irregular	irregular	ADJ
admet-2756	40	27	bone	bone	NOUN
admet-2756	40	28	growth	growth	NOUN
admet-2756	40	29	1987	1987	NUM
admet-2756	40	30	mgi	mgi	PROPN
admet-2756	40	31	pharma	pharma	PROPN
admet-2756	40	32	aredia	aredia	PROPN
admet-2756	40	33	pamidronate	pamidronate	PROPN
admet-2756	40	34	hypercalcemia	hypercalcemia	NOUN
admet-2756	40	35	of	of	ADP
admet-2756	40	36	malignancy	malignancy	NOUN
admet-2756	40	37	,	,	PUNCT
admet-2756	40	38	paget	paget	PROPN
admet-2756	40	39	’s	’s	PART
admet-2756	40	40	disease	disease	NOUN
admet-2756	40	41	,	,	PUNCT
admet-2756	40	42	bone	bone	NOUN
admet-2756	40	43	damage	damage	NOUN
admet-2756	40	44	caused	cause	VERB
admet-2756	40	45	by	by	ADP
admet-2756	40	46	breast	breast	NOUN
admet-2756	40	47	/	/	SYM
admet-2756	40	48	bone	bone	NOUN
admet-2756	40	49	marrow	marrow	NOUN
admet-2756	40	50	cancer	cancer	NOUN
admet-2756	40	51	1991	1991	NUM
admet-2756	40	52	pfizer	pfizer	NOUN
admet-2756	40	53	fosamax	fosamax	NOUN
admet-2756	40	54	alendronate	alendronate	NOUN
admet-2756	40	55	osteoporosis	osteoporosis	NOUN
admet-2756	40	56	1995	1995	NUM
admet-2756	40	57	merck	merck	PROPN
admet-2756	40	58	skelid	skelid	PROPN
admet-2756	40	59	tiludronate	tiludronate	PROPN
admet-2756	40	60	paget	paget	PROPN
admet-2756	40	61	’s	’s	PART
admet-2756	40	62	disease	disease	NOUN
admet-2756	40	63	1997	1997	NUM
admet-2756	40	64	sanofi	sanofi	PROPN
admet-2756	40	65	actonel	actonel	PROPN
admet-2756	40	66	risedronate	risedronate	PROPN
admet-2756	40	67	osteoporosis	osteoporosis	NOUN
admet-2756	40	68	,	,	PUNCT
admet-2756	40	69	paget	paget	PROPN
admet-2756	40	70	’s	’s	PART
admet-2756	40	71	disease	disease	NOUN
admet-2756	40	72	1998	1998	NUM
admet-2756	40	73	procter	procter	PROPN
admet-2756	40	74	&	&	CCONJ
admet-2756	40	75	gamble	gamble	PROPN
admet-2756	40	76	pharmaceuticals	pharmaceutical	NOUN
admet-2756	40	77	zometa	zometa	PROPN
admet-2756	40	78	zoledronate	zoledronate	PROPN
admet-2756	40	79	hypercalcemia	hypercalcemia	NOUN
admet-2756	40	80	of	of	ADP
admet-2756	40	81	malignancy	malignancy	NOUN
admet-2756	40	82	,	,	PUNCT
admet-2756	40	83	multiple	multiple	ADJ
admet-2756	40	84	myeloma	myeloma	PROPN
admet-2756	40	85	2002	2002	NUM
admet-2756	40	86	novartis	novartis	PROPN
admet-2756	40	87	boniva	boniva	NOUN
admet-2756	40	88	ibandronate	ibandronate	PROPN
admet-2756	40	89	osteoporosis	osteoporosis	NOUN
admet-2756	40	90	2003	2003	NUM
admet-2756	40	91	roche	roche	NOUN
admet-2756	40	92	therapeutics	therapeutic	NOUN
admet-2756	40	93	fosamax	fosamax	NOUN
admet-2756	40	94	plus	plus	CCONJ
admet-2756	40	95	d	d	ADP
admet-2756	40	96	alendronate	alendronate	NOUN
admet-2756	40	97	/	/	SYM
admet-2756	40	98	cholecalciferol	cholecalciferol	NOUN
admet-2756	40	99	osteoporosis	osteoporosis	NOUN
admet-2756	40	100	2005	2005	NUM
admet-2756	40	101	merck	merck	PROPN
admet-2756	40	102	actonel	actonel	NOUN
admet-2756	40	103	with	with	ADP
admet-2756	40	104	calcium	calcium	NOUN
admet-2756	40	105	risedronate	risedronate	NOUN
admet-2756	40	106	/	/	SYM
admet-2756	40	107	calcium	calcium	NOUN
admet-2756	40	108	carbonate	carbonate	NOUN
admet-2756	40	109	osteoporosis	osteoporosis	NOUN
admet-2756	40	110	,	,	PUNCT
admet-2756	40	111	paget	paget	PROPN
admet-2756	40	112	’s	’s	PART
admet-2756	40	113	disease	disease	NOUN
admet-2756	40	114	2005	2005	NUM
admet-2756	40	115	procter	procter	PROPN
admet-2756	40	116	&	&	CCONJ
admet-2756	40	117	gamble	gamble	PROPN
admet-2756	40	118	pharmaceuticals	pharmaceutical	NOUN
admet-2756	40	119	aclasta	aclasta	NOUN
admet-2756	40	120	zoledronate	zoledronate	PROPN
admet-2756	40	121	osteoporosis	osteoporosis	NOUN
admet-2756	40	122	,	,	PUNCT
admet-2756	40	123	paget	paget	PROPN
admet-2756	40	124	’s	’s	PART
admet-2756	40	125	disease	disease	NOUN
admet-2756	40	126	2007	2007	NUM
admet-2756	40	127	novartis	novartis	PROPN
admet-2756	40	128	reclast	reclast	NOUN
admet-2756	40	129	zoledronate	zoledronate	PROPN
admet-2756	40	130	osteoporosis	osteoporosis	NOUN
admet-2756	40	131	2007	2007	NUM
admet-2756	40	132	novartis	novartis	PROPN
admet-2756	40	133	atelvia	atelvia	PROPN
admet-2756	40	134	risedronate	risedronate	VERB
admet-2756	40	135	osteoporosis	osteoporosis	NOUN
admet-2756	40	136	2010	2010	NUM
admet-2756	40	137	sanofi	sanofi	NOUN
admet-2756	40	138	binosto	binosto	NOUN
admet-2756	40	139	alendronate	alendronate	NOUN
admet-2756	40	140	osteoporosis	osteoporosis	NOUN
admet-2756	40	141	2012	2012	NUM
admet-2756	40	142	effrx	effrx	ADJ
admet-2756	40	143	pharmaceuticals	pharmaceutical	NOUN
admet-2756	40	144	sa	sa	NOUN
admet-2756	40	145	aside	aside	ADV
admet-2756	40	146	from	from	ADP
admet-2756	40	147	traditional	traditional	ADJ
admet-2756	40	148	bone	bone	NOUN
admet-2756	40	149	disorders	disorder	NOUN
admet-2756	40	150	such	such	ADJ
admet-2756	40	151	as	as	ADP
admet-2756	40	152	osteoporosis	osteoporosis	NOUN
admet-2756	40	153	and	and	CCONJ
admet-2756	40	154	paget	paget	PROPN
admet-2756	40	155	’s	’s	PART
admet-2756	40	156	disease	disease	NOUN
admet-2756	40	157	,	,	PUNCT
admet-2756	40	158	which	which	PRON
admet-2756	40	159	involve	involve	VERB
admet-2756	40	160	high	high	ADJ
admet-2756	40	161	bone	bone	NOUN
admet-2756	40	162	turnover	turnover	NOUN
admet-2756	40	163	,	,	PUNCT
admet-2756	40	164	tumour	tumour	NOUN
admet-2756	40	165	development	development	NOUN
admet-2756	40	166	in	in	ADP
admet-2756	40	167	bone	bone	NOUN
admet-2756	40	168	tissue	tissue	NOUN
admet-2756	40	169	is	be	AUX
admet-2756	40	170	another	another	DET
admet-2756	40	171	condition	condition	NOUN
admet-2756	40	172	that	that	PRON
admet-2756	40	173	leads	lead	VERB
admet-2756	40	174	to	to	ADP
admet-2756	40	175	extreme	extreme	ADJ
admet-2756	40	176	osteoclast	osteoclast	ADJ
admet-2756	40	177	activity	activity	NOUN
admet-2756	40	178	.	.	PUNCT
admet-2756	41	1	studies	study	NOUN
admet-2756	41	2	have	have	AUX
admet-2756	41	3	revealed	reveal	VERB
admet-2756	41	4	that	that	SCONJ
admet-2756	41	5	upon	upon	SCONJ
admet-2756	41	6	the	the	DET
admet-2756	41	7	formation	formation	NOUN
admet-2756	41	8	of	of	ADP
admet-2756	41	9	a	a	DET
admet-2756	41	10	tumour	tumour	NOUN
admet-2756	41	11	in	in	ADP
admet-2756	41	12	bone	bone	NOUN
admet-2756	41	13	tissue	tissue	NOUN
admet-2756	41	14	,	,	PUNCT
admet-2756	41	15	osteoclasts	osteoclast	NOUN
admet-2756	41	16	and	and	CCONJ
admet-2756	41	17	cancerous	cancerous	ADJ
admet-2756	41	18	cells	cell	NOUN
admet-2756	41	19	contribute	contribute	VERB
admet-2756	41	20	to	to	ADP
admet-2756	41	21	the	the	DET
admet-2756	41	22	growth	growth	NOUN
admet-2756	41	23	and	and	CCONJ
admet-2756	41	24	activity	activity	NOUN
admet-2756	41	25	of	of	ADP
admet-2756	41	26	each	each	DET
admet-2756	41	27	other	other	ADJ
admet-2756	41	28	.	.	PUNCT
admet-2756	42	1	cancerous	cancerous	ADJ
admet-2756	42	2	cells	cell	NOUN
admet-2756	42	3	release	release	VERB
admet-2756	42	4	certain	certain	ADJ
admet-2756	42	5	growth	growth	NOUN
admet-2756	42	6	factors	factor	NOUN
admet-2756	42	7	in	in	ADP
admet-2756	42	8	bone	bone	NOUN
admet-2756	42	9	tissue	tissue	NOUN
admet-2756	42	10	that	that	PRON
admet-2756	42	11	promote	promote	VERB
admet-2756	42	12	osteoclast	osteoclast	ADJ
admet-2756	42	13	activity	activity	NOUN
admet-2756	42	14	and	and	CCONJ
admet-2756	42	15	osteoclast	osteoclast	ADJ
admet-2756	42	16	differentiation	differentiation	NOUN
admet-2756	42	17	.	.	PUNCT
admet-2756	43	1	similarly	similarly	ADV
admet-2756	43	2	,	,	PUNCT
admet-2756	43	3	osteoclasts	osteoclast	NOUN
admet-2756	43	4	release	release	VERB
admet-2756	43	5	growth	growth	NOUN
admet-2756	43	6	factors	factor	NOUN
admet-2756	43	7	that	that	PRON
admet-2756	43	8	contribute	contribute	VERB
admet-2756	43	9	to	to	ADP
admet-2756	43	10	tumour	tumour	NOUN
admet-2756	43	11	cell	cell	NOUN
admet-2756	43	12	growth	growth	NOUN
admet-2756	43	13	,	,	PUNCT
admet-2756	43	14	proliferation	proliferation	NOUN
admet-2756	43	15	,	,	PUNCT
admet-2756	43	16	and	and	CCONJ
admet-2756	43	17	metastasis	metastasis	NOUN
admet-2756	43	18	[	[	X
admet-2756	43	19	13	13	NUM
admet-2756	43	20	]	]	PUNCT
admet-2756	43	21	.	.	PUNCT
admet-2756	44	1	in	in	ADP
admet-2756	44	2	addition	addition	NOUN
admet-2756	44	3	to	to	ADP
admet-2756	44	4	anti	anti	ADJ
admet-2756	44	5	-	-	ADJ
admet-2756	44	6	osteoclast	osteoclast	ADJ
admet-2756	44	7	activity	activity	NOUN
admet-2756	44	8	,	,	PUNCT
admet-2756	44	9	bps	bps	NOUN
admet-2756	44	10	have	have	AUX
admet-2756	44	11	been	be	AUX
admet-2756	44	12	reported	report	VERB
admet-2756	44	13	to	to	PART
admet-2756	44	14	exhibit	exhibit	VERB
admet-2756	44	15	anticancer	anticancer	NOUN
admet-2756	44	16	properties	property	NOUN
admet-2756	44	17	.	.	PUNCT
admet-2756	45	1	they	they	PRON
admet-2756	45	2	interfere	interfere	VERB
admet-2756	45	3	with	with	ADP
admet-2756	45	4	the	the	DET
admet-2756	45	5	process	process	NOUN
admet-2756	45	6	of	of	ADP
admet-2756	45	7	cell	cell	NOUN
admet-2756	45	8	migration	migration	NOUN
admet-2756	45	9	,	,	PUNCT
admet-2756	45	10	adhesion	adhesion	NOUN
admet-2756	45	11	,	,	PUNCT
admet-2756	45	12	and	and	CCONJ
admet-2756	45	13	angiogenesis	angiogenesis	NOUN
admet-2756	45	14	.	.	PUNCT
admet-2756	46	1	moreover	moreover	ADV
admet-2756	46	2	,	,	PUNCT
admet-2756	46	3	they	they	PRON
admet-2756	46	4	can	can	AUX
admet-2756	46	5	have	have	VERB
admet-2756	46	6	synergistic	synergistic	ADJ
admet-2756	46	7	anticancer	anticancer	NOUN
admet-2756	46	8	effects	effect	NOUN
admet-2756	46	9	with	with	ADP
admet-2756	46	10	chemotherapeutic	chemotherapeutic	ADJ
admet-2756	46	11	agents	agent	NOUN
admet-2756	46	12	and	and	CCONJ
admet-2756	46	13	elicit	elicit	ADJ
admet-2756	46	14	immune	immune	ADJ
admet-2756	46	15	responses	response	NOUN
admet-2756	46	16	against	against	ADP
admet-2756	46	17	tumours	tumour	NOUN
admet-2756	47	1	[	[	X
admet-2756	47	2	14,15	14,15	NUM
admet-2756	47	3	]	]	PUNCT
admet-2756	47	4	.	.	PUNCT
admet-2756	48	1	given	give	VERB
admet-2756	48	2	their	their	PRON
admet-2756	48	3	dual	dual	ADJ
admet-2756	48	4	role	role	NOUN
admet-2756	48	5	as	as	ADP
admet-2756	48	6	osteoclast	osteoclast	ADJ
admet-2756	48	7	inhibitors	inhibitor	NOUN
admet-2756	48	8	and	and	CCONJ
admet-2756	48	9	well	well	ADV
admet-2756	48	10	-	-	PUNCT
admet-2756	48	11	established	establish	VERB
admet-2756	48	12	targeting	targeting	NOUN
admet-2756	48	13	ligands	ligand	NOUN
admet-2756	48	14	for	for	ADP
admet-2756	48	15	the	the	DET
admet-2756	48	16	bone	bone	NOUN
admet-2756	48	17	mineral	mineral	NOUN
admet-2756	48	18	matrix	matrix	NOUN
admet-2756	48	19	,	,	PUNCT
admet-2756	48	20	along	along	ADP
admet-2756	48	21	with	with	ADP
admet-2756	48	22	their	their	PRON
admet-2756	48	23	demonstrated	demonstrate	VERB
admet-2756	48	24	anticancer	anticancer	NOUN
admet-2756	48	25	effects	effect	NOUN
admet-2756	48	26	,	,	PUNCT
admet-2756	48	27	bps	bps	NOUN
admet-2756	48	28	present	present	VERB
admet-2756	48	29	a	a	DET
admet-2756	48	30	promising	promising	ADJ
admet-2756	48	31	avenue	avenue	NOUN
admet-2756	48	32	for	for	ADP
admet-2756	48	33	designing	design	VERB
admet-2756	48	34	drug	drug	NOUN
admet-2756	48	35	delivery	delivery	NOUN
admet-2756	48	36	systems	system	NOUN
admet-2756	48	37	to	to	PART
admet-2756	48	38	treat	treat	VERB
admet-2756	48	39	various	various	ADJ
admet-2756	48	40	types	type	NOUN
admet-2756	48	41	of	of	ADP
admet-2756	48	42	bone	bone	NOUN
admet-2756	48	43	-	-	PUNCT
admet-2756	48	44	related	relate	VERB
admet-2756	48	45	cancers	cancer	NOUN
admet-2756	48	46	.	.	PUNCT
admet-2756	49	1	not	not	PART
admet-2756	49	2	only	only	ADV
admet-2756	49	3	can	can	AUX
admet-2756	49	4	they	they	PRON
admet-2756	49	5	be	be	AUX
admet-2756	49	6	employed	employ	VERB
admet-2756	49	7	to	to	PART
admet-2756	49	8	deliver	deliver	VERB
admet-2756	49	9	an	an	DET
admet-2756	49	10	anticancer	anticancer	NOUN
admet-2756	49	11	agent	agent	NOUN
admet-2756	49	12	to	to	ADP
admet-2756	49	13	the	the	DET
admet-2756	49	14	site	site	NOUN
admet-2756	49	15	of	of	ADP
admet-2756	49	16	bone	bone	NOUN
admet-2756	49	17	tumours	tumours	PROPN
admet-2756	49	18	selectively	selectively	ADV
admet-2756	49	19	,	,	PUNCT
admet-2756	49	20	but	but	CCONJ
admet-2756	49	21	also	also	ADV
admet-2756	49	22	their	their	PRON
admet-2756	49	23	pharmacodynamic	pharmacodynamic	ADJ
admet-2756	49	24	properties	property	NOUN
admet-2756	49	25	can	can	AUX
admet-2756	49	26	be	be	AUX
admet-2756	49	27	leveraged	leverage	VERB
admet-2756	49	28	to	to	PART
admet-2756	49	29	control	control	VERB
admet-2756	49	30	osteoclast	osteoclast	ADJ
admet-2756	49	31	activity	activity	NOUN
admet-2756	49	32	and	and	CCONJ
admet-2756	49	33	prevent	prevent	VERB
admet-2756	49	34	pathological	pathological	ADJ
admet-2756	49	35	fractures	fracture	NOUN
admet-2756	49	36	in	in	ADP
admet-2756	49	37	the	the	DET
admet-2756	49	38	tumour	tumour	NOUN
admet-2756	49	39	-	-	PUNCT
admet-2756	49	40	bearing	bear	VERB
admet-2756	49	41	bone	bone	NOUN
admet-2756	49	42	.	.	PUNCT
admet-2756	50	1	for	for	ADP
admet-2756	50	2	these	these	DET
admet-2756	50	3	reasons	reason	NOUN
admet-2756	50	4	,	,	PUNCT
admet-2756	50	5	bps	bps	NOUN
admet-2756	50	6	have	have	AUX
admet-2756	50	7	been	be	AUX
admet-2756	50	8	a	a	DET
admet-2756	50	9	major	major	ADJ
admet-2756	50	10	area	area	NOUN
admet-2756	50	11	of	of	ADP
admet-2756	50	12	focus	focus	NOUN
admet-2756	50	13	for	for	ADP
admet-2756	50	14	researchers	researcher	NOUN
admet-2756	50	15	in	in	ADP
admet-2756	50	16	the	the	DET
admet-2756	50	17	past	past	ADJ
admet-2756	50	18	decade	decade	NOUN
admet-2756	50	19	.	.	PUNCT
admet-2756	51	1	this	this	DET
admet-2756	51	2	review	review	NOUN
admet-2756	51	3	provides	provide	VERB
admet-2756	51	4	a	a	DET
admet-2756	51	5	comprehensive	comprehensive	ADJ
admet-2756	51	6	analysis	analysis	NOUN
admet-2756	51	7	of	of	ADP
admet-2756	51	8	the	the	DET
admet-2756	51	9	literature	literature	NOUN
admet-2756	51	10	on	on	ADP
admet-2756	51	11	drug	drug	NOUN
admet-2756	51	12	delivery	delivery	NOUN
admet-2756	51	13	systems	system	NOUN
admet-2756	51	14	designed	design	VERB
admet-2756	51	15	using	use	VERB
admet-2756	51	16	bps	bps	NOUN
admet-2756	51	17	for	for	ADP
admet-2756	51	18	targeted	target	VERB
admet-2756	51	19	drug	drug	NOUN
admet-2756	51	20	delivery	delivery	NOUN
admet-2756	51	21	to	to	ADP
admet-2756	51	22	bone	bone	NOUN
admet-2756	51	23	tumours	tumour	NOUN
admet-2756	51	24	.	.	PUNCT
admet-2756	52	1	the	the	DET
admet-2756	52	2	literature	literature	NOUN
admet-2756	52	3	reports	report	NOUN
admet-2756	52	4	have	have	AUX
admet-2756	52	5	been	be	AUX
admet-2756	52	6	categorized	categorize	VERB
admet-2756	52	7	based	base	VERB
admet-2756	52	8	on	on	ADP
admet-2756	52	9	the	the	DET
admet-2756	52	10	class	class	NOUN
admet-2756	52	11	of	of	ADP
admet-2756	52	12	the	the	DET
admet-2756	52	13	drug	drug	NOUN
admet-2756	52	14	delivery	delivery	NOUN
admet-2756	52	15	systems	system	NOUN
admet-2756	52	16	.	.	PUNCT
admet-2756	53	1	furthermore	furthermore	ADV
admet-2756	53	2	,	,	PUNCT
admet-2756	53	3	the	the	DET
admet-2756	53	4	review	review	NOUN
admet-2756	53	5	highlights	highlight	VERB
admet-2756	53	6	the	the	DET
admet-2756	53	7	major	major	ADJ
admet-2756	53	8	advantages	advantage	NOUN
admet-2756	53	9	and	and	CCONJ
admet-2756	53	10	limitations	limitation	NOUN
admet-2756	53	11	of	of	ADP
admet-2756	53	12	bisphosphonate	bisphosphonate	NOUN
admet-2756	53	13	-	-	PUNCT
admet-2756	53	14	based	base	VERB
admet-2756	53	15	drug	drug	NOUN
admet-2756	53	16	delivery	delivery	NOUN
admet-2756	53	17	systems	system	NOUN
admet-2756	53	18	and	and	CCONJ
admet-2756	53	19	offers	offer	VERB
admet-2756	53	20	the	the	DET
admet-2756	53	21	authors	author	NOUN
admet-2756	53	22	'	'	PART
admet-2756	53	23	perspective	perspective	NOUN
admet-2756	53	24	on	on	ADP
admet-2756	53	25	future	future	ADJ
admet-2756	53	26	directions	direction	NOUN
admet-2756	53	27	for	for	ADP
admet-2756	53	28	bone	bone	NOUN
admet-2756	53	29	-	-	PUNCT
admet-2756	53	30	targeting	target	VERB
admet-2756	53	31	therapies	therapy	NOUN
admet-2756	53	32	.	.	PUNCT
admet-2756	54	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	54	2	-	-	PUNCT
admet-2756	54	3	drug	drug	NOUN
admet-2756	54	4	conjugates	conjugate	NOUN
admet-2756	54	5	due	due	ADJ
admet-2756	54	6	to	to	ADP
admet-2756	54	7	its	its	PRON
admet-2756	54	8	straightforward	straightforward	ADJ
admet-2756	54	9	preparation	preparation	NOUN
admet-2756	54	10	process	process	NOUN
admet-2756	54	11	,	,	PUNCT
admet-2756	54	12	the	the	DET
admet-2756	54	13	direct	direct	ADJ
admet-2756	54	14	conjugation	conjugation	NOUN
admet-2756	54	15	of	of	ADP
admet-2756	54	16	drugs	drug	NOUN
admet-2756	54	17	with	with	ADP
admet-2756	54	18	a	a	DET
admet-2756	54	19	bisphosphonate	bisphosphonate	NOUN
admet-2756	54	20	molecule	molecule	NOUN
admet-2756	54	21	,	,	PUNCT
admet-2756	54	22	utilizing	utilize	VERB
admet-2756	54	23	cleavable	cleavable	ADJ
admet-2756	54	24	bonds	bond	NOUN
admet-2756	54	25	under	under	ADP
admet-2756	54	26	specific	specific	ADJ
admet-2756	54	27	physiological	physiological	ADJ
admet-2756	54	28	conditions	condition	NOUN
admet-2756	54	29	,	,	PUNCT
admet-2756	54	30	has	have	AUX
admet-2756	54	31	become	become	VERB
admet-2756	54	32	a	a	DET
admet-2756	54	33	widely	widely	ADV
admet-2756	54	34	adopted	adopt	VERB
admet-2756	54	35	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	54	36	m.	m.	NOUN
admet-2756	54	37	eshaghi	eshaghi	PROPN
admet-2756	54	38	et	et	PROPN
admet-2756	54	39	al	al	PROPN
admet-2756	54	40	.	.	PROPN
admet-2756	54	41	admet	admet	PROPN
admet-2756	54	42	&	&	CCONJ
admet-2756	54	43	dmpk	dmpk	PROPN
admet-2756	54	44	13(3	13(3	NUM
admet-2756	54	45	)	)	PUNCT
admet-2756	54	46	(	(	PUNCT
admet-2756	54	47	2025	2025	NUM
admet-2756	54	48	)	)	PUNCT
admet-2756	54	49	2756	2756	NUM
admet-2756	54	50	4	4	NUM
admet-2756	54	51	strategy	strategy	NOUN
admet-2756	54	52	in	in	ADP
admet-2756	54	53	bone	bone	NOUN
admet-2756	54	54	-	-	PUNCT
admet-2756	54	55	targeted	target	VERB
admet-2756	54	56	drug	drug	NOUN
admet-2756	54	57	delivery	delivery	NOUN
admet-2756	54	58	.	.	PUNCT
admet-2756	55	1	table	table	NOUN
admet-2756	55	2	3	3	NUM
admet-2756	55	3	summarizes	summarize	VERB
admet-2756	55	4	the	the	DET
admet-2756	55	5	details	detail	NOUN
admet-2756	55	6	of	of	ADP
admet-2756	55	7	various	various	ADJ
admet-2756	55	8	bisphosphonate	bisphosphonate	NOUN
admet-2756	55	9	conjugated	conjugate	VERB
admet-2756	55	10	systems	system	NOUN
admet-2756	55	11	.	.	PUNCT
admet-2756	56	1	in	in	ADP
admet-2756	56	2	this	this	DET
admet-2756	56	3	table	table	NOUN
admet-2756	56	4	,	,	PUNCT
admet-2756	56	5	the	the	DET
admet-2756	56	6	position	position	NOUN
admet-2756	56	7	of	of	ADP
admet-2756	56	8	the	the	DET
admet-2756	56	9	bps	bps	NOUN
admet-2756	56	10	in	in	ADP
admet-2756	56	11	the	the	DET
admet-2756	56	12	bisphosphonate	bisphosphonate	NOUN
admet-2756	56	13	-	-	PUNCT
admet-2756	56	14	drug	drug	NOUN
admet-2756	56	15	complex	complex	NOUN
admet-2756	56	16	is	be	AUX
admet-2756	56	17	reported	report	VERB
admet-2756	56	18	as	as	ADP
admet-2756	56	19	either	either	CCONJ
admet-2756	56	20	an	an	DET
admet-2756	56	21	‘	'	PUNCT
admet-2756	56	22	outside	outside	ADJ
admet-2756	56	23	network	network	NOUN
admet-2756	56	24	’	'	PUNCT
admet-2756	56	25	or	or	CCONJ
admet-2756	56	26	a	a	DET
admet-2756	56	27	‘	'	PUNCT
admet-2756	56	28	within	within	ADP
admet-2756	56	29	network	network	NOUN
admet-2756	56	30	’	'	PUNCT
admet-2756	56	31	.	.	PUNCT
admet-2756	57	1	the	the	DET
admet-2756	57	2	former	former	ADJ
admet-2756	57	3	indicates	indicate	VERB
admet-2756	57	4	that	that	SCONJ
admet-2756	57	5	the	the	DET
admet-2756	57	6	majority	majority	NOUN
admet-2756	57	7	of	of	ADP
admet-2756	57	8	bisphosphonate	bisphosphonate	ADJ
admet-2756	57	9	molecule	molecule	NOUN
admet-2756	57	10	arms	arm	NOUN
admet-2756	57	11	,	,	PUNCT
admet-2756	57	12	including	include	VERB
admet-2756	57	13	oh	oh	NUM
admet-2756	57	14	groups	group	NOUN
admet-2756	57	15	,	,	PUNCT
admet-2756	57	16	r1	r1	NOUN
admet-2756	57	17	and	and	CCONJ
admet-2756	57	18	r2	r2	PROPN
admet-2756	57	19	,	,	PUNCT
admet-2756	57	20	are	be	AUX
admet-2756	57	21	exposed	expose	VERB
admet-2756	57	22	and	and	CCONJ
admet-2756	57	23	free	free	ADJ
admet-2756	57	24	for	for	ADP
admet-2756	57	25	binding	bind	VERB
admet-2756	57	26	to	to	ADP
admet-2756	57	27	the	the	DET
admet-2756	57	28	bone	bone	NOUN
admet-2756	57	29	matrix	matrix	NOUN
admet-2756	57	30	,	,	PUNCT
admet-2756	57	31	while	while	SCONJ
admet-2756	57	32	the	the	DET
admet-2756	57	33	latter	latter	ADJ
admet-2756	57	34	means	mean	VERB
admet-2756	57	35	that	that	SCONJ
admet-2756	57	36	most	most	ADJ
admet-2756	57	37	of	of	ADP
admet-2756	57	38	these	these	DET
admet-2756	57	39	arms	arm	NOUN
admet-2756	57	40	are	be	AUX
admet-2756	57	41	engaged	engage	VERB
admet-2756	57	42	with	with	ADP
admet-2756	57	43	drug	drug	NOUN
admet-2756	57	44	molecules	molecule	NOUN
admet-2756	57	45	to	to	PART
admet-2756	57	46	form	form	VERB
admet-2756	57	47	the	the	DET
admet-2756	57	48	conjugate	conjugate	NOUN
admet-2756	57	49	.	.	PUNCT
admet-2756	58	1	the	the	DET
admet-2756	58	2	assumption	assumption	NOUN
admet-2756	58	3	is	be	AUX
admet-2756	58	4	that	that	SCONJ
admet-2756	58	5	the	the	DET
admet-2756	58	6	“	"	PUNCT
admet-2756	58	7	outside	outside	ADJ
admet-2756	58	8	networks	network	NOUN
admet-2756	58	9	”	"	PUNCT
admet-2756	58	10	are	be	AUX
admet-2756	58	11	more	more	ADV
admet-2756	58	12	favourable	favourable	ADJ
admet-2756	58	13	for	for	ADP
admet-2756	58	14	targeting	target	VERB
admet-2756	58	15	purposes	purpose	NOUN
admet-2756	58	16	as	as	SCONJ
admet-2756	58	17	they	they	PRON
admet-2756	58	18	have	have	VERB
admet-2756	58	19	more	more	ADV
admet-2756	58	20	free	free	ADJ
admet-2756	58	21	arms	arm	NOUN
admet-2756	58	22	for	for	ADP
admet-2756	58	23	binding	bind	VERB
admet-2756	58	24	to	to	ADP
admet-2756	58	25	the	the	DET
admet-2756	58	26	bone	bone	NOUN
admet-2756	58	27	matrix	matrix	NOUN
admet-2756	58	28	.	.	PUNCT
admet-2756	59	1	nevertheless	nevertheless	ADV
admet-2756	59	2	,	,	PUNCT
admet-2756	59	3	multiple	multiple	ADJ
admet-2756	59	4	studies	study	NOUN
admet-2756	59	5	have	have	AUX
admet-2756	59	6	reported	report	VERB
admet-2756	59	7	that	that	SCONJ
admet-2756	59	8	“	"	PUNCT
admet-2756	59	9	within	within	ADP
admet-2756	59	10	networks	network	NOUN
admet-2756	59	11	”	"	PUNCT
admet-2756	59	12	have	have	VERB
admet-2756	59	13	effective	effective	ADJ
admet-2756	59	14	bone	bone	NOUN
admet-2756	59	15	-	-	PUNCT
admet-2756	59	16	targeting	target	VERB
admet-2756	59	17	properties	property	NOUN
admet-2756	59	18	.	.	PUNCT
admet-2756	60	1	interestingly	interestingly	ADV
admet-2756	60	2	,	,	PUNCT
admet-2756	60	3	systems	system	NOUN
admet-2756	60	4	that	that	PRON
admet-2756	60	5	engage	engage	VERB
admet-2756	61	1	all	all	PRON
admet-2756	61	2	oh	oh	NUM
admet-2756	61	3	arms	arm	NOUN
admet-2756	61	4	of	of	ADP
admet-2756	61	5	bisphosphonate	bisphosphonate	NOUN
admet-2756	61	6	,	,	PUNCT
admet-2756	61	7	for	for	ADP
admet-2756	61	8	forming	form	VERB
admet-2756	61	9	the	the	DET
admet-2756	61	10	complex	complex	NOUN
admet-2756	61	11	,	,	PUNCT
admet-2756	61	12	have	have	AUX
admet-2756	61	13	demonstrated	demonstrate	VERB
admet-2756	61	14	satisfactory	satisfactory	ADJ
admet-2756	61	15	in	in	ADP
admet-2756	61	16	vivo	vivo	ADJ
admet-2756	61	17	distribution	distribution	NOUN
admet-2756	61	18	[	[	X
admet-2756	61	19	16	16	NUM
admet-2756	61	20	-	-	SYM
admet-2756	61	21	19	19	NUM
admet-2756	61	22	]	]	PUNCT
admet-2756	61	23	.	.	PUNCT
admet-2756	62	1	table	table	NOUN
admet-2756	62	2	3	3	NUM
admet-2756	62	3	.	.	PUNCT
admet-2756	62	4	structural	structural	ADJ
admet-2756	62	5	details	detail	NOUN
admet-2756	62	6	and	and	CCONJ
admet-2756	62	7	targeting	target	VERB
admet-2756	62	8	efficiency	efficiency	NOUN
admet-2756	62	9	of	of	ADP
admet-2756	62	10	bp	bp	NOUN
admet-2756	62	11	-	-	PUNCT
admet-2756	62	12	drug	drug	NOUN
admet-2756	62	13	conjugate	conjugate	ADJ
admet-2756	62	14	systems	system	NOUN
admet-2756	62	15	drug	drug	NOUN
admet-2756	62	16	name	name	NOUN
admet-2756	62	17	bisphosphonate	bisphosphonate	NOUN
admet-2756	62	18	name	name	NOUN
admet-2756	62	19	type	type	NOUN
admet-2756	62	20	of	of	ADP
admet-2756	62	21	conjugation	conjugation	NOUN
admet-2756	62	22	bps	bps	NOUN
admet-2756	62	23	position	position	NOUN
admet-2756	62	24	*	*	PUNCT
admet-2756	63	1	*	*	PUNCT
admet-2756	63	2	*	*	PUNCT
admet-2756	63	3	*	*	PUNCT
admet-2756	63	4	outcome	outcome	NOUN
admet-2756	63	5	ref	ref	NOUN
admet-2756	63	6	.	.	PUNCT
admet-2756	64	1	doxorubicin	doxorubicin	PROPN
admet-2756	64	2	(	(	PUNCT
admet-2756	64	3	dox	dox	NOUN
admet-2756	64	4	)	)	PUNCT
admet-2756	64	5	alendronate	alendronate	NOUN
admet-2756	64	6	hydrazone	hydrazone	NOUN
admet-2756	64	7	bond	bond	NOUN
admet-2756	64	8	outside	outside	ADP
admet-2756	64	9	highly	highly	ADV
admet-2756	64	10	efficient	efficient	ADJ
admet-2756	64	11	bone	bone	NOUN
admet-2756	64	12	targeting	target	VERB
admet-2756	64	13	in	in	ADP
admet-2756	64	14	vitro	vitro	X
admet-2756	64	15	and	and	CCONJ
admet-2756	64	16	in	in	ADP
admet-2756	64	17	vivo	vivo	NOUN
admet-2756	64	18	[	[	X
admet-2756	64	19	20	20	NUM
admet-2756	64	20	]	]	SYM
admet-2756	64	21	5	5	NUM
admet-2756	64	22	-	-	PUNCT
admet-2756	64	23	fluorodeoxyuridine	fluorodeoxyuridine	NOUN
admet-2756	64	24	(	(	PUNCT
admet-2756	64	25	5f	5f	NOUN
admet-2756	64	26	)	)	PUNCT
admet-2756	64	27	alendronate	alendronate	PROPN
admet-2756	64	28	non	non	ADJ
admet-2756	64	29	-	-	ADJ
admet-2756	64	30	cleavable	cleavable	ADJ
admet-2756	64	31	covalent	covalent	NOUN
admet-2756	64	32	bond	bond	NOUN
admet-2756	64	33	outside	outside	ADP
admet-2756	64	34	low	low	ADJ
admet-2756	64	35	therapeutic	therapeutic	ADJ
admet-2756	64	36	impact	impact	NOUN
admet-2756	64	37	due	due	ADP
admet-2756	64	38	to	to	ADP
admet-2756	64	39	non	non	ADJ
admet-2756	64	40	-	-	ADJ
admet-2756	64	41	cleavable	cleavable	ADJ
admet-2756	64	42	linker	linker	NOUN
admet-2756	64	43	[	[	X
admet-2756	64	44	21	21	NUM
admet-2756	64	45	]	]	X
admet-2756	64	46	platinum	platinum	NOUN
admet-2756	64	47	isopropyl	isopropyl	NOUN
admet-2756	64	48	amine	amine	NOUN
admet-2756	64	49	(	(	PUNCT
admet-2756	64	50	ptc3	ptc3	ADJ
admet-2756	64	51	)	)	PUNCT
admet-2756	64	52	alendronate	alendronate	PROPN
admet-2756	64	53	/	/	SYM
admet-2756	64	54	pamidronate	pamidronate	NOUN
admet-2756	64	55	chelation	chelation	NOUN
admet-2756	64	56	by	by	ADP
admet-2756	64	57	p	p	PROPN
admet-2756	64	58	=	=	PROPN
admet-2756	64	59	o	o	NOUN
admet-2756	64	60	arms	arm	NOUN
admet-2756	64	61	outside	outside	ADP
admet-2756	64	62	pmd	pmd	NOUN
admet-2756	64	63	targeting	target	VERB
admet-2756	64	64	function	function	NOUN
admet-2756	64	65	maintained	maintain	VERB
admet-2756	64	66	after	after	ADP
admet-2756	64	67	conjugation	conjugation	NOUN
admet-2756	64	68	[	[	X
admet-2756	64	69	22	22	NUM
admet-2756	64	70	]	]	X
admet-2756	64	71	palladium	palladium	NOUN
admet-2756	64	72	ii	ii	PROPN
admet-2756	64	73	alendronate	alendronate	VERB
admet-2756	64	74	ionic	ionic	ADJ
admet-2756	64	75	conjugation	conjugation	NOUN
admet-2756	64	76	within	within	ADP
admet-2756	64	77	more	more	ADJ
admet-2756	64	78	than	than	ADP
admet-2756	64	79	95	95	NUM
admet-2756	64	80	%	%	NOUN
admet-2756	64	81	binding	bind	VERB
admet-2756	64	82	to	to	ADP
admet-2756	64	83	hap	hap	VERB
admet-2756	64	84	in	in	ADP
admet-2756	64	85	vitro	vitro	X
admet-2756	64	86	[	[	X
admet-2756	64	87	19	19	NUM
admet-2756	64	88	]	]	PUNCT
admet-2756	64	89	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	64	90	)	)	PUNCT
admet-2756	64	91	bp-15	bp-15	NOUN
admet-2756	64	92	*	*	PUNCT
admet-2756	64	93	ionic	ionic	ADJ
admet-2756	64	94	conjugation	conjugation	NOUN
admet-2756	64	95	within	within	ADP
admet-2756	64	96	selective	selective	ADJ
admet-2756	64	97	accumulation	accumulation	NOUN
admet-2756	64	98	in	in	ADP
admet-2756	64	99	hard	hard	ADJ
admet-2756	64	100	tissues	tissue	NOUN
admet-2756	64	101	over	over	ADP
admet-2756	64	102	soft	soft	ADJ
admet-2756	64	103	tissues	tissue	NOUN
admet-2756	65	1	[	[	X
admet-2756	65	2	17	17	NUM
admet-2756	65	3	]	]	PUNCT
admet-2756	65	4	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	65	5	)	)	PUNCT
admet-2756	65	6	bp-15	bp-15	PART
admet-2756	65	7	ionic	ionic	ADJ
admet-2756	65	8	conjugation	conjugation	NOUN
admet-2756	65	9	within	within	ADP
admet-2756	65	10	selective	selective	ADJ
admet-2756	65	11	accumulation	accumulation	NOUN
admet-2756	65	12	in	in	ADP
admet-2756	65	13	hard	hard	ADJ
admet-2756	65	14	tissues	tissue	NOUN
admet-2756	65	15	over	over	ADP
admet-2756	65	16	soft	soft	ADJ
admet-2756	65	17	tissues	tissue	NOUN
admet-2756	66	1	[	[	X
admet-2756	66	2	18	18	NUM
admet-2756	66	3	]	]	PUNCT
admet-2756	66	4	dox	dox	NOUN
admet-2756	66	5	12b80	12b80	NUM
admet-2756	66	6	*	*	PUNCT
admet-2756	66	7	*	*	PUNCT
admet-2756	66	8	hydrazone	hydrazone	NOUN
admet-2756	66	9	bond	bond	NOUN
admet-2756	66	10	outside	outside	ADP
admet-2756	66	11	highly	highly	ADV
admet-2756	66	12	efficient	efficient	ADJ
admet-2756	66	13	bone	bone	NOUN
admet-2756	66	14	targeting	target	VERB
admet-2756	66	15	in	in	ADP
admet-2756	66	16	vitro	vitro	X
admet-2756	66	17	and	and	CCONJ
admet-2756	66	18	in	in	ADP
admet-2756	66	19	vivo	vivo	NOUN
admet-2756	66	20	[	[	X
admet-2756	66	21	23	23	NUM
admet-2756	66	22	]	]	X
admet-2756	66	23	bortezomib	bortezomib	NOUN
admet-2756	66	24	(	(	PUNCT
admet-2756	66	25	btz	btz	PROPN
admet-2756	66	26	)	)	PUNCT
admet-2756	66	27	bp-22	bp-22	VERB
admet-2756	66	28	*	*	PUNCT
admet-2756	66	29	*	*	PUNCT
admet-2756	66	30	*	*	PUNCT
admet-2756	66	31	boronate	boronate	NOUN
admet-2756	66	32	ester	ester	NOUN
admet-2756	66	33	bond	bond	NOUN
admet-2756	66	34	outside	outside	ADP
admet-2756	66	35	no	no	DET
admet-2756	66	36	direct	direct	ADJ
admet-2756	66	37	bone	bone	NOUN
admet-2756	66	38	affinity	affinity	NOUN
admet-2756	66	39	assay	assay	VERB
admet-2756	66	40	,	,	PUNCT
admet-2756	66	41	biological	biological	ADJ
admet-2756	66	42	tests	test	NOUN
admet-2756	66	43	support	support	VERB
admet-2756	66	44	effective	effective	ADJ
admet-2756	66	45	bone	bone	NOUN
admet-2756	66	46	targeting	target	VERB
admet-2756	66	47	[	[	X
admet-2756	66	48	24	24	NUM
admet-2756	66	49	]	]	X
admet-2756	66	50	*	*	PUNCT
admet-2756	66	51	(	(	PUNCT
admet-2756	66	52	bp15	bp15	PROPN
admet-2756	66	53	):	):	PUNCT
admet-2756	66	54	2	2	NUM
admet-2756	66	55	-	-	PUNCT
admet-2756	66	56	amino-1	amino-1	NUM
admet-2756	66	57	-	-	PUNCT
admet-2756	66	58	hydroxyethane-1,1	hydroxyethane-1,1	PRON
admet-2756	66	59	-	-	PUNCT
admet-2756	66	60	diyl	diyl	NOUN
admet-2756	66	61	-	-	PUNCT
admet-2756	66	62	bisphosphonate	bisphosphonate	NOUN
admet-2756	66	63	*	*	NOUN
admet-2756	66	64	*	*	PUNCT
admet-2756	66	65	(	(	PUNCT
admet-2756	66	66	12b80	12b80	NUM
admet-2756	66	67	):	):	PUNCT
admet-2756	66	68	dox	dox	NOUN
admet-2756	66	69	-	-	PUNCT
admet-2756	66	70	conjugated	conjugate	VERB
admet-2756	66	71	bp-21	bp-21	ADJ
admet-2756	66	72	*	*	PUNCT
admet-2756	66	73	*	*	PUNCT
admet-2756	66	74	*	*	PUNCT
admet-2756	66	75	(	(	PUNCT
admet-2756	66	76	bp-22	bp-22	X
admet-2756	66	77	):	):	PUNCT
admet-2756	66	78	2-(bis(2	2-(bis(2	NOUN
admet-2756	66	79	-	-	NOUN
admet-2756	66	80	hydroxyethyl)amino)ethyl(bis(diethoxyphosphoryl)methyl)carbamate	hydroxyethyl)amino)ethyl(bis(diethoxyphosphoryl)methyl)carbamate	NOUN
admet-2756	66	81	*	*	PUNCT
admet-2756	66	82	*	*	PUNCT
admet-2756	66	83	*	*	PUNCT
admet-2756	66	84	*	*	PUNCT
admet-2756	66	85	(	(	PUNCT
admet-2756	66	86	bps	bps	NOUN
admet-2756	66	87	position	position	NOUN
admet-2756	66	88	):	):	PUNCT
admet-2756	66	89	the	the	DET
admet-2756	66	90	position	position	NOUN
admet-2756	66	91	of	of	ADP
admet-2756	66	92	the	the	DET
admet-2756	66	93	bps	bps	NOUN
admet-2756	66	94	in	in	ADP
admet-2756	66	95	the	the	DET
admet-2756	66	96	bisphosphonate	bisphosphonate	NOUN
admet-2756	66	97	-	-	PUNCT
admet-2756	66	98	drug	drug	NOUN
admet-2756	66	99	complex	complex	NOUN
admet-2756	66	100	has	have	AUX
admet-2756	66	101	been	be	AUX
admet-2756	66	102	reported	report	VERB
admet-2756	66	103	as	as	ADP
admet-2756	66	104	either	either	CCONJ
admet-2756	66	105	‘	'	PUNCT
admet-2756	66	106	outside	outside	ADJ
admet-2756	66	107	network	network	NOUN
admet-2756	66	108	’	'	PUNCT
admet-2756	66	109	or	or	CCONJ
admet-2756	66	110	‘	'	PUNCT
admet-2756	66	111	within	within	ADP
admet-2756	66	112	network	network	NOUN
admet-2756	66	113	’	'	PUNCT
admet-2756	66	114	schem	schem	PROPN
admet-2756	66	115	et	et	PROPN
admet-2756	66	116	al	al	PROPN
admet-2756	66	117	.	.	PUNCT
admet-2756	67	1	[	[	X
admet-2756	67	2	21	21	NUM
admet-2756	67	3	]	]	PUNCT
admet-2756	67	4	developed	develop	VERB
admet-2756	67	5	a	a	DET
admet-2756	67	6	non	non	ADJ
admet-2756	67	7	-	-	ADJ
admet-2756	67	8	cleavable	cleavable	ADJ
admet-2756	67	9	conjugate	conjugate	NOUN
admet-2756	67	10	between	between	ADP
admet-2756	67	11	aln	aln	PROPN
admet-2756	67	12	and	and	CCONJ
admet-2756	67	13	an	an	DET
admet-2756	67	14	antimetabolite	antimetabolite	ADJ
admet-2756	67	15	drug	drug	NOUN
admet-2756	67	16	,	,	PUNCT
admet-2756	67	17	5	5	NUM
admet-2756	67	18	-	-	PUNCT
admet-2756	67	19	fluorodeoxyuridine	fluorodeoxyuridine	NOUN
admet-2756	67	20	(	(	PUNCT
admet-2756	67	21	5f	5f	NOUN
admet-2756	67	22	)	)	PUNCT
admet-2756	67	23	,	,	PUNCT
admet-2756	67	24	and	and	CCONJ
admet-2756	67	25	assessed	assess	VERB
admet-2756	67	26	the	the	DET
admet-2756	67	27	compound	compound	NOUN
admet-2756	67	28	’s	’s	PART
admet-2756	67	29	application	application	NOUN
admet-2756	67	30	for	for	ADP
admet-2756	67	31	treating	treat	VERB
admet-2756	67	32	breast	breast	NOUN
admet-2756	67	33	cancer	cancer	NOUN
admet-2756	67	34	bone	bone	NOUN
admet-2756	67	35	metastasis	metastasis	NOUN
admet-2756	67	36	.	.	PUNCT
admet-2756	68	1	in	in	ADP
admet-2756	68	2	vitro	vitro	X
admet-2756	68	3	,	,	PUNCT
admet-2756	68	4	a	a	DET
admet-2756	68	5	cell	cell	NOUN
admet-2756	68	6	viability	viability	NOUN
admet-2756	68	7	assay	assay	NOUN
admet-2756	68	8	was	be	AUX
admet-2756	68	9	performed	perform	VERB
admet-2756	68	10	for	for	ADP
admet-2756	68	11	multiple	multiple	ADJ
admet-2756	68	12	breast	breast	NOUN
admet-2756	68	13	cancer	cancer	NOUN
admet-2756	68	14	cell	cell	NOUN
admet-2756	68	15	lines	line	NOUN
admet-2756	68	16	,	,	PUNCT
admet-2756	68	17	which	which	PRON
admet-2756	68	18	were	be	AUX
admet-2756	68	19	treated	treat	VERB
admet-2756	68	20	with	with	ADP
admet-2756	68	21	free	free	ADJ
admet-2756	68	22	5f	5f	NOUN
admet-2756	68	23	,	,	PUNCT
admet-2756	68	24	free	free	PROPN
admet-2756	68	25	aln	aln	PROPN
admet-2756	68	26	,	,	PUNCT
admet-2756	68	27	or	or	CCONJ
admet-2756	68	28	aln-5f	aln-5f	PROPN
admet-2756	68	29	conjugate	conjugate	NOUN
admet-2756	68	30	.	.	PUNCT
admet-2756	69	1	free	free	ADJ
admet-2756	69	2	5f	5f	NOUN
admet-2756	69	3	and	and	CCONJ
admet-2756	69	4	free	free	PROPN
admet-2756	69	5	aln	aln	PROPN
admet-2756	69	6	exhibited	exhibit	VERB
admet-2756	69	7	stronger	strong	ADJ
admet-2756	69	8	cytotoxicity	cytotoxicity	NOUN
admet-2756	69	9	than	than	ADP
admet-2756	69	10	aln-5f	aln-5f	ADJ
admet-2756	69	11	.	.	PUNCT
admet-2756	70	1	experiments	experiment	NOUN
admet-2756	70	2	by	by	ADP
admet-2756	70	3	nude	nude	ADJ
admet-2756	70	4	mice	mouse	NOUN
admet-2756	70	5	revealed	reveal	VERB
admet-2756	70	6	that	that	SCONJ
admet-2756	70	7	free	free	PROPN
admet-2756	70	8	aln	aln	PROPN
admet-2756	70	9	is	be	AUX
admet-2756	70	10	superior	superior	ADJ
admet-2756	70	11	to	to	ADP
admet-2756	70	12	free	free	VERB
admet-2756	70	13	5f	5f	NOUN
admet-2756	70	14	and	and	CCONJ
admet-2756	70	15	aln-5f	aln-5f	ADJ
admet-2756	70	16	in	in	ADP
admet-2756	70	17	terms	term	NOUN
admet-2756	70	18	of	of	ADP
admet-2756	70	19	reducing	reduce	VERB
admet-2756	70	20	tumour	tumour	NOUN
admet-2756	70	21	size	size	NOUN
admet-2756	70	22	in	in	ADP
admet-2756	70	23	vivo	vivo	NOUN
admet-2756	70	24	.	.	PUNCT
admet-2756	71	1	authors	author	NOUN
admet-2756	71	2	attributed	attribute	VERB
admet-2756	71	3	the	the	DET
admet-2756	71	4	lack	lack	NOUN
admet-2756	71	5	of	of	ADP
admet-2756	71	6	superior	superior	ADJ
admet-2756	71	7	therapeutic	therapeutic	ADJ
admet-2756	71	8	results	result	NOUN
admet-2756	71	9	for	for	ADP
admet-2756	71	10	aln-5f	aln-5f	PROPN
admet-2756	71	11	compared	compare	VERB
admet-2756	71	12	to	to	ADP
admet-2756	71	13	free	free	PROPN
admet-2756	71	14	aln	aln	PROPN
admet-2756	71	15	and	and	CCONJ
admet-2756	71	16	free	free	ADJ
admet-2756	71	17	5f	5f	NOUN
admet-2756	71	18	to	to	ADP
admet-2756	71	19	the	the	DET
admet-2756	71	20	non	non	ADJ
admet-2756	71	21	-	-	ADJ
admet-2756	71	22	cleavable	cleavable	ADJ
admet-2756	71	23	nature	nature	NOUN
admet-2756	71	24	of	of	ADP
admet-2756	71	25	the	the	DET
admet-2756	71	26	bond	bond	NOUN
admet-2756	71	27	between	between	ADP
admet-2756	71	28	aln	aln	PROPN
admet-2756	71	29	and	and	CCONJ
admet-2756	71	30	5f	5f	NOUN
admet-2756	71	31	,	,	PUNCT
admet-2756	71	32	which	which	PRON
admet-2756	71	33	hinders	hinder	VERB
admet-2756	71	34	the	the	DET
admet-2756	71	35	pharmacodynamic	pharmacodynamic	ADJ
admet-2756	71	36	properties	property	NOUN
admet-2756	71	37	of	of	ADP
admet-2756	71	38	both	both	DET
admet-2756	71	39	agents	agent	NOUN
admet-2756	71	40	.	.	PUNCT
admet-2756	72	1	ye	ye	PRON
admet-2756	72	2	et	et	NOUN
admet-2756	72	3	al	al	PROPN
admet-2756	72	4	.	.	PUNCT
admet-2756	73	1	[	[	X
admet-2756	73	2	20	20	NUM
admet-2756	73	3	]	]	X
admet-2756	73	4	conjugated	conjugated	ADJ
admet-2756	73	5	hydrazine	hydrazine	NOUN
admet-2756	73	6	and	and	CCONJ
admet-2756	73	7	monoethyl	monoethyl	NOUN
admet-2756	73	8	adipate	adipate	PROPN
admet-2756	73	9	(	(	PUNCT
admet-2756	73	10	hyd	hyd	NOUN
admet-2756	73	11	)	)	PUNCT
admet-2756	73	12	,	,	PUNCT
admet-2756	73	13	using	use	VERB
admet-2756	73	14	it	it	PRON
admet-2756	73	15	as	as	ADP
admet-2756	73	16	a	a	DET
admet-2756	73	17	ph	ph	ADJ
admet-2756	73	18	-	-	ADJ
admet-2756	73	19	sensitive	sensitive	ADJ
admet-2756	73	20	linker	linker	NOUN
admet-2756	73	21	to	to	PART
admet-2756	73	22	conjugate	conjugate	VERB
admet-2756	73	23	doxorubicin	doxorubicin	PROPN
admet-2756	73	24	(	(	PUNCT
admet-2756	73	25	dox	dox	NOUN
admet-2756	73	26	)	)	PUNCT
admet-2756	73	27	,	,	PUNCT
admet-2756	73	28	as	as	ADP
admet-2756	73	29	the	the	DET
admet-2756	73	30	anticancer	anticancer	NOUN
admet-2756	73	31	drug	drug	NOUN
admet-2756	73	32	and	and	CCONJ
admet-2756	73	33	aln	aln	PROPN
admet-2756	73	34	,	,	PUNCT
admet-2756	73	35	as	as	ADP
admet-2756	73	36	the	the	DET
admet-2756	73	37	targeting	targeting	NOUN
admet-2756	73	38	ligand	ligand	NOUN
admet-2756	73	39	(	(	PUNCT
admet-2756	73	40	dox	dox	NOUN
admet-2756	73	41	-	-	PUNCT
admet-2756	73	42	hyd	hyd	NOUN
admet-2756	73	43	-	-	PUNCT
admet-2756	73	44	aln	aln	PROPN
admet-2756	73	45	)	)	PUNCT
admet-2756	73	46	.	.	PUNCT
admet-2756	74	1	the	the	DET
admet-2756	74	2	hydrazone	hydrazone	NOUN
admet-2756	74	3	bond	bond	NOUN
admet-2756	74	4	is	be	AUX
admet-2756	74	5	among	among	ADP
admet-2756	74	6	the	the	DET
admet-2756	74	7	most	most	ADV
admet-2756	74	8	widely	widely	ADV
admet-2756	74	9	applied	apply	VERB
admet-2756	74	10	linkers	linker	NOUN
admet-2756	74	11	for	for	ADP
admet-2756	74	12	ph	ph	VERB
admet-2756	74	13	-	-	PUNCT
admet-2756	74	14	controlled	control	VERB
admet-2756	74	15	drug	drug	NOUN
admet-2756	74	16	release	release	NOUN
admet-2756	74	17	.	.	PUNCT
admet-2756	75	1	according	accord	VERB
admet-2756	75	2	to	to	ADP
admet-2756	75	3	the	the	DET
admet-2756	75	4	hap	hap	NOUN
admet-2756	75	5	binding	bind	VERB
admet-2756	75	6	assay	assay	NOUN
admet-2756	75	7	,	,	PUNCT
admet-2756	75	8	over	over	ADP
admet-2756	75	9	80	80	NUM
admet-2756	75	10	%	%	NOUN
admet-2756	75	11	of	of	ADP
admet-2756	75	12	dox	dox	NOUN
admet-2756	75	13	-	-	PUNCT
admet-2756	75	14	hyd	hyd	NOUN
admet-2756	75	15	-	-	PUNCT
admet-2756	75	16	aln	aln	PROPN
admet-2756	75	17	was	be	AUX
admet-2756	75	18	bound	bind	VERB
admet-2756	75	19	to	to	PART
admet-2756	75	20	hap	hap	VERB
admet-2756	75	21	in	in	ADP
admet-2756	75	22	90	90	NUM
admet-2756	75	23	minutes	minute	NOUN
admet-2756	75	24	,	,	PUNCT
admet-2756	75	25	which	which	PRON
admet-2756	75	26	was	be	AUX
admet-2756	75	27	70	70	NUM
admet-2756	75	28	%	%	NOUN
admet-2756	75	29	more	more	ADJ
admet-2756	75	30	than	than	ADP
admet-2756	75	31	that	that	PRON
admet-2756	75	32	of	of	ADP
admet-2756	75	33	free	free	ADJ
admet-2756	75	34	dox	dox	NOUN
admet-2756	75	35	.	.	PUNCT
admet-2756	76	1	in	in	ADP
admet-2756	76	2	addition	addition	NOUN
admet-2756	76	3	,	,	PUNCT
admet-2756	76	4	in	in	ADP
admet-2756	76	5	vivo	vivo	ADJ
admet-2756	76	6	biodistribution	biodistribution	NOUN
admet-2756	76	7	assay	assay	NOUN
admet-2756	76	8	indicated	indicate	VERB
admet-2756	76	9	a	a	DET
admet-2756	76	10	significant	significant	ADJ
admet-2756	76	11	accumulation	accumulation	NOUN
admet-2756	76	12	of	of	ADP
admet-2756	76	13	doxhyd	doxhyd	NOUN
admet-2756	76	14	-	-	PUNCT
admet-2756	76	15	aln	aln	NOUN
admet-2756	76	16	in	in	ADP
admet-2756	76	17	tumour	tumour	NOUN
admet-2756	76	18	-	-	PUNCT
admet-2756	76	19	bearing	bear	VERB
admet-2756	76	20	bone	bone	NOUN
admet-2756	76	21	and	and	CCONJ
admet-2756	76	22	negligible	negligible	ADJ
admet-2756	76	23	concentrations	concentration	NOUN
admet-2756	76	24	in	in	ADP
admet-2756	76	25	other	other	ADJ
admet-2756	76	26	organs	organ	NOUN
admet-2756	76	27	.	.	PUNCT
admet-2756	77	1	these	these	DET
admet-2756	77	2	results	result	NOUN
admet-2756	77	3	demonstrate	demonstrate	VERB
admet-2756	77	4	the	the	DET
admet-2756	77	5	effective	effective	ADJ
admet-2756	77	6	targeting	targeting	NOUN
admet-2756	77	7	efficiency	efficiency	NOUN
admet-2756	77	8	of	of	ADP
admet-2756	77	9	aln	aln	PROPN
admet-2756	77	10	and	and	CCONJ
admet-2756	77	11	promise	promise	VERB
admet-2756	77	12	fewer	few	ADJ
admet-2756	77	13	severe	severe	ADJ
admet-2756	77	14	side	side	NOUN
admet-2756	77	15	effects	effect	NOUN
admet-2756	77	16	.	.	PUNCT
admet-2756	78	1	in	in	ADP
admet-2756	78	2	vivo	vivo	ADJ
admet-2756	78	3	studies	study	NOUN
admet-2756	78	4	using	use	VERB
admet-2756	78	5	nude	nude	ADJ
admet-2756	78	6	mice	mouse	NOUN
admet-2756	78	7	revealed	reveal	VERB
admet-2756	78	8	that	that	SCONJ
admet-2756	78	9	dox	dox	NOUN
admet-2756	78	10	-	-	PUNCT
admet-2756	78	11	hyd	hyd	NOUN
admet-2756	78	12	-	-	PUNCT
admet-2756	78	13	aln	aln	PROPN
admet-2756	78	14	can	can	AUX
admet-2756	78	15	decrease	decrease	VERB
admet-2756	78	16	tumour	tumour	ADJ
admet-2756	78	17	growth	growth	NOUN
admet-2756	78	18	rate	rate	NOUN
admet-2756	78	19	significantly	significantly	ADV
admet-2756	78	20	compared	compare	VERB
admet-2756	78	21	to	to	ADP
admet-2756	78	22	free	free	ADJ
admet-2756	78	23	dox	dox	NOUN
admet-2756	78	24	.	.	PUNCT
admet-2756	79	1	the	the	DET
admet-2756	79	2	admet	admet	PROPN
admet-2756	79	3	&	&	CCONJ
admet-2756	79	4	dmpk	dmpk	PROPN
admet-2756	79	5	13(3	13(3	NUM
admet-2756	79	6	)	)	PUNCT
admet-2756	79	7	(	(	PUNCT
admet-2756	79	8	2025	2025	NUM
admet-2756	79	9	)	)	PUNCT
admet-2756	79	10	2756	2756	NUM
admet-2756	79	11	bisphosphonates	bisphosphonate	NOUN
admet-2756	79	12	for	for	ADP
admet-2756	79	13	bone	bone	NOUN
admet-2756	79	14	cancer	cancer	NOUN
admet-2756	79	15	therapy	therapy	NOUN
admet-2756	79	16	doi	doi	NOUN
admet-2756	79	17	:	:	PUNCT
admet-2756	79	18	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	79	19	5	5	NUM
admet-2756	79	20	improved	improved	ADJ
admet-2756	79	21	performance	performance	NOUN
admet-2756	79	22	of	of	ADP
admet-2756	79	23	the	the	DET
admet-2756	79	24	conjugated	conjugated	ADJ
admet-2756	79	25	system	system	NOUN
admet-2756	79	26	compared	compare	VERB
admet-2756	79	27	to	to	ADP
admet-2756	79	28	the	the	DET
admet-2756	79	29	free	free	ADJ
admet-2756	79	30	drug	drug	NOUN
admet-2756	79	31	can	can	AUX
admet-2756	79	32	be	be	AUX
admet-2756	79	33	attributed	attribute	VERB
admet-2756	79	34	to	to	ADP
admet-2756	79	35	alnmediated	alnmediate	VERB
admet-2756	79	36	targeting	targeting	NOUN
admet-2756	79	37	,	,	PUNCT
admet-2756	79	38	which	which	PRON
admet-2756	79	39	increases	increase	VERB
admet-2756	79	40	drug	drug	NOUN
admet-2756	79	41	concentration	concentration	NOUN
admet-2756	79	42	in	in	ADP
admet-2756	79	43	the	the	DET
admet-2756	79	44	tumour	tumour	NOUN
admet-2756	79	45	site	site	NOUN
admet-2756	79	46	.	.	PUNCT
admet-2756	80	1	alvarez	alvarez	PROPN
admet-2756	80	2	-	-	PUNCT
admet-2756	80	3	valdez	valdez	PROPN
admet-2756	80	4	et	et	PROPN
admet-2756	80	5	al	al	PROPN
admet-2756	80	6	.	.	PUNCT
admet-2756	81	1	[	[	X
admet-2756	81	2	22	22	NUM
admet-2756	81	3	]	]	X
admet-2756	81	4	prepared	prepared	ADJ
admet-2756	81	5	complexes	complex	NOUN
admet-2756	81	6	made	make	VERB
admet-2756	81	7	of	of	ADP
admet-2756	81	8	two	two	NUM
admet-2756	81	9	different	different	ADJ
admet-2756	81	10	bps	bps	NOUN
admet-2756	81	11	,	,	PUNCT
admet-2756	81	12	aln	aln	NOUN
admet-2756	81	13	or	or	CCONJ
admet-2756	81	14	pamidronate	pamidronate	PROPN
admet-2756	81	15	(	(	PUNCT
admet-2756	81	16	pmd	pmd	PROPN
admet-2756	81	17	)	)	PUNCT
admet-2756	81	18	,	,	PUNCT
admet-2756	81	19	as	as	ADP
admet-2756	81	20	targeting	target	VERB
admet-2756	81	21	ligand	ligand	NOUN
admet-2756	81	22	,	,	PUNCT
admet-2756	81	23	and	and	CCONJ
admet-2756	81	24	platinum	platinum	NOUN
admet-2756	81	25	isopropyl	isopropyl	NOUN
admet-2756	81	26	amine	amine	NOUN
admet-2756	81	27	(	(	PUNCT
admet-2756	81	28	ptc3	ptc3	PROPN
admet-2756	81	29	)	)	PUNCT
admet-2756	81	30	,	,	PUNCT
admet-2756	81	31	as	as	ADP
admet-2756	81	32	the	the	DET
admet-2756	81	33	drug	drug	NOUN
admet-2756	81	34	,	,	PUNCT
admet-2756	81	35	(	(	PUNCT
admet-2756	81	36	bp	bp	PROPN
admet-2756	81	37	-	-	ADJ
admet-2756	81	38	ptc3	ptc3	ADJ
admet-2756	81	39	)	)	PUNCT
admet-2756	81	40	.	.	PUNCT
admet-2756	82	1	p	p	X
admet-2756	82	2	=	=	ADJ
admet-2756	82	3	o	o	NOUN
admet-2756	82	4	arms	arm	NOUN
admet-2756	82	5	of	of	ADP
admet-2756	82	6	aln	aln	PROPN
admet-2756	82	7	and	and	CCONJ
admet-2756	82	8	pmd	pmd	PROPN
admet-2756	82	9	acted	act	VERB
admet-2756	82	10	as	as	ADP
admet-2756	82	11	chelating	chelate	VERB
admet-2756	82	12	agents	agent	NOUN
admet-2756	82	13	to	to	PART
admet-2756	82	14	form	form	VERB
admet-2756	82	15	a	a	DET
admet-2756	82	16	complex	complex	NOUN
admet-2756	82	17	with	with	ADP
admet-2756	82	18	ptc3	ptc3	PROPN
admet-2756	82	19	.	.	PUNCT
admet-2756	83	1	the	the	DET
admet-2756	83	2	goal	goal	NOUN
admet-2756	83	3	here	here	ADV
admet-2756	83	4	was	be	AUX
admet-2756	83	5	to	to	PART
admet-2756	83	6	determine	determine	VERB
admet-2756	83	7	the	the	DET
admet-2756	83	8	targeting	targeting	NOUN
admet-2756	83	9	capability	capability	NOUN
admet-2756	83	10	of	of	ADP
admet-2756	83	11	the	the	DET
admet-2756	83	12	two	two	NUM
admet-2756	83	13	complexes	complex	NOUN
admet-2756	83	14	for	for	ADP
admet-2756	83	15	bone	bone	NOUN
admet-2756	83	16	mineral	mineral	NOUN
admet-2756	83	17	matrix	matrix	NOUN
admet-2756	83	18	.	.	PUNCT
admet-2756	84	1	to	to	ADP
admet-2756	84	2	this	this	DET
admet-2756	84	3	end	end	NOUN
admet-2756	84	4	,	,	PUNCT
admet-2756	84	5	a	a	DET
admet-2756	84	6	1h	1h	NUM
admet-2756	84	7	nmr	nmr	NOUN
admet-2756	84	8	test	test	NOUN
admet-2756	84	9	was	be	AUX
admet-2756	84	10	used	use	VERB
admet-2756	84	11	to	to	PART
admet-2756	84	12	assess	assess	VERB
admet-2756	84	13	the	the	DET
admet-2756	84	14	binding	bind	VERB
admet-2756	84	15	affinity	affinity	NOUN
admet-2756	84	16	of	of	ADP
admet-2756	84	17	aln	aln	PROPN
admet-2756	84	18	-	-	PUNCT
admet-2756	84	19	ptc3	ptc3	PROPN
admet-2756	84	20	and	and	CCONJ
admet-2756	84	21	pmd	pmd	PROPN
admet-2756	84	22	-	-	ADJ
admet-2756	84	23	ptc3	ptc3	PROPN
admet-2756	84	24	for	for	ADP
admet-2756	84	25	hap	hap	NOUN
admet-2756	84	26	.	.	PUNCT
admet-2756	85	1	the	the	DET
admet-2756	85	2	methodology	methodology	NOUN
admet-2756	85	3	included	include	VERB
admet-2756	85	4	incubating	incubate	VERB
admet-2756	85	5	a	a	DET
admet-2756	85	6	defined	define	VERB
admet-2756	85	7	concentration	concentration	NOUN
admet-2756	85	8	of	of	ADP
admet-2756	85	9	each	each	DET
admet-2756	85	10	complex	complex	NOUN
admet-2756	85	11	with	with	ADP
admet-2756	85	12	varying	vary	VERB
admet-2756	85	13	concentrations	concentration	NOUN
admet-2756	85	14	of	of	ADP
admet-2756	85	15	hap	hap	NOUN
admet-2756	85	16	,	,	PUNCT
admet-2756	85	17	testing	test	VERB
admet-2756	85	18	the	the	DET
admet-2756	85	19	supernatant	supernatant	NOUN
admet-2756	85	20	with	with	ADP
admet-2756	85	21	1h	1h	NUM
admet-2756	85	22	nmr	nmr	NOUN
admet-2756	85	23	spectroscopy	spectroscopy	NOUN
admet-2756	85	24	after	after	ADP
admet-2756	85	25	centrifugation	centrifugation	NOUN
admet-2756	85	26	,	,	PUNCT
admet-2756	85	27	and	and	CCONJ
admet-2756	85	28	monitoring	monitor	VERB
admet-2756	85	29	the	the	DET
admet-2756	85	30	changes	change	NOUN
admet-2756	85	31	in	in	ADP
admet-2756	85	32	the	the	DET
admet-2756	85	33	nmr	nmr	NOUN
admet-2756	85	34	spectrum	spectrum	NOUN
admet-2756	85	35	.	.	PUNCT
admet-2756	86	1	1h	1h	NUM
admet-2756	86	2	nmr	nmr	NOUN
admet-2756	86	3	analysis	analysis	NOUN
admet-2756	86	4	indicated	indicate	VERB
admet-2756	86	5	that	that	SCONJ
admet-2756	86	6	the	the	DET
admet-2756	86	7	affinity	affinity	NOUN
admet-2756	86	8	of	of	ADP
admet-2756	86	9	pmd	pmd	PROPN
admet-2756	86	10	for	for	ADP
admet-2756	86	11	hap	hap	NOUN
admet-2756	86	12	was	be	AUX
admet-2756	86	13	not	not	PART
admet-2756	86	14	compromised	compromise	VERB
admet-2756	86	15	as	as	ADP
admet-2756	86	16	a	a	DET
admet-2756	86	17	result	result	NOUN
admet-2756	86	18	of	of	ADP
admet-2756	86	19	forming	form	VERB
admet-2756	86	20	a	a	DET
admet-2756	86	21	complex	complex	NOUN
admet-2756	86	22	with	with	ADP
admet-2756	86	23	ptc3	ptc3	PROPN
admet-2756	86	24	.	.	PUNCT
admet-2756	87	1	however	however	ADV
admet-2756	87	2	,	,	PUNCT
admet-2756	87	3	aln	aln	PROPN
admet-2756	87	4	lost	lose	VERB
admet-2756	87	5	its	its	PRON
admet-2756	87	6	binding	bind	VERB
admet-2756	87	7	affinity	affinity	NOUN
admet-2756	87	8	for	for	ADP
admet-2756	87	9	hap	hap	NOUN
admet-2756	87	10	after	after	ADP
admet-2756	87	11	forming	form	VERB
admet-2756	87	12	a	a	DET
admet-2756	87	13	complex	complex	NOUN
admet-2756	87	14	with	with	ADP
admet-2756	87	15	ptc3	ptc3	PROPN
admet-2756	87	16	.	.	PUNCT
admet-2756	88	1	therefore	therefore	ADV
admet-2756	88	2	,	,	PUNCT
admet-2756	88	3	pmd	pmd	PROPN
admet-2756	88	4	can	can	AUX
admet-2756	88	5	be	be	AUX
admet-2756	88	6	used	use	VERB
admet-2756	88	7	as	as	ADP
admet-2756	88	8	a	a	DET
admet-2756	88	9	targeting	targeting	NOUN
admet-2756	88	10	ligand	ligand	NOUN
admet-2756	88	11	to	to	PART
admet-2756	88	12	deliver	deliver	VERB
admet-2756	88	13	ptc3	ptc3	ADV
admet-2756	88	14	to	to	ADP
admet-2756	88	15	bone	bone	NOUN
admet-2756	88	16	tissue	tissue	NOUN
admet-2756	88	17	.	.	PUNCT
admet-2756	89	1	david	david	PROPN
admet-2756	89	2	et	et	PROPN
admet-2756	89	3	al	al	PROPN
admet-2756	89	4	.	.	PUNCT
admet-2756	90	1	[	[	X
admet-2756	90	2	23	23	NUM
admet-2756	90	3	]	]	PUNCT
admet-2756	90	4	used	use	VERB
admet-2756	90	5	a	a	DET
admet-2756	90	6	hydrazone	hydrazone	NOUN
admet-2756	90	7	-	-	PUNCT
admet-2756	90	8	based	base	VERB
admet-2756	90	9	linker	linker	NOUN
admet-2756	90	10	to	to	PART
admet-2756	90	11	conjugate	conjugate	VERB
admet-2756	90	12	dox	dox	NOUN
admet-2756	90	13	and	and	CCONJ
admet-2756	90	14	a	a	DET
admet-2756	90	15	synthetic	synthetic	ADJ
admet-2756	90	16	bisphosphonate	bisphosphonate	NOUN
admet-2756	90	17	(	(	PUNCT
admet-2756	90	18	bp-21	bp-21	X
admet-2756	90	19	)	)	PUNCT
admet-2756	90	20	to	to	PART
admet-2756	90	21	obtain	obtain	VERB
admet-2756	90	22	a	a	DET
admet-2756	90	23	ph	ph	ADJ
admet-2756	90	24	-	-	ADJ
admet-2756	90	25	sensitive	sensitive	ADJ
admet-2756	90	26	system	system	NOUN
admet-2756	90	27	,	,	PUNCT
admet-2756	90	28	named	name	VERB
admet-2756	90	29	12b80	12b80	NUM
admet-2756	90	30	.	.	PUNCT
admet-2756	91	1	the	the	DET
admet-2756	91	2	chemical	chemical	ADJ
admet-2756	91	3	structure	structure	NOUN
admet-2756	91	4	of	of	ADP
admet-2756	91	5	bp-21	bp-21	PROPN
admet-2756	91	6	can	can	AUX
admet-2756	91	7	be	be	AUX
admet-2756	91	8	observed	observe	VERB
admet-2756	91	9	in	in	ADP
admet-2756	91	10	figure	figure	NOUN
admet-2756	91	11	2a	2a	NUM
admet-2756	91	12	.	.	PUNCT
admet-2756	92	1	bp-21	bp-21	PROPN
admet-2756	92	2	was	be	AUX
admet-2756	92	3	prepared	prepare	VERB
admet-2756	92	4	from	from	ADP
admet-2756	92	5	3-(3	3-(3	PROPN
admet-2756	92	6	-	-	PUNCT
admet-2756	92	7	bromopropoxy)benzaldehyde	bromopropoxy)benzaldehyde	PROPN
admet-2756	92	8	in	in	ADP
admet-2756	92	9	a	a	DET
admet-2756	92	10	6	6	NUM
admet-2756	92	11	-	-	PUNCT
admet-2756	92	12	step	step	NOUN
admet-2756	92	13	procedure	procedure	NOUN
admet-2756	92	14	.	.	PUNCT
admet-2756	93	1	as	as	SCONJ
admet-2756	93	2	shown	show	VERB
admet-2756	93	3	in	in	ADP
admet-2756	93	4	figure	figure	NOUN
admet-2756	93	5	2a	2a	NUM
admet-2756	93	6	,	,	PUNCT
admet-2756	93	7	the	the	DET
admet-2756	93	8	novelty	novelty	NOUN
admet-2756	93	9	of	of	ADP
admet-2756	93	10	bp-21	bp-21	ADJ
admet-2756	93	11	is	be	AUX
admet-2756	93	12	in	in	ADP
admet-2756	93	13	its	its	PRON
admet-2756	93	14	r2	r2	NOUN
admet-2756	93	15	arm	arm	NOUN
admet-2756	93	16	structure	structure	NOUN
admet-2756	93	17	.	.	PUNCT
admet-2756	94	1	five	five	NUM
admet-2756	94	2	out	out	ADP
admet-2756	94	3	of	of	ADP
admet-2756	94	4	six	six	NUM
admet-2756	94	5	steps	step	NOUN
admet-2756	94	6	of	of	ADP
admet-2756	94	7	the	the	DET
admet-2756	94	8	synthesis	synthesis	NOUN
admet-2756	94	9	protocol	protocol	NOUN
admet-2756	94	10	are	be	AUX
admet-2756	94	11	concerned	concern	VERB
admet-2756	94	12	with	with	ADP
admet-2756	94	13	the	the	DET
admet-2756	94	14	preparation	preparation	NOUN
admet-2756	94	15	of	of	ADP
admet-2756	94	16	this	this	DET
admet-2756	94	17	structure	structure	NOUN
admet-2756	94	18	,	,	PUNCT
admet-2756	94	19	which	which	PRON
admet-2756	94	20	eventually	eventually	ADV
admet-2756	94	21	turns	turn	VERB
admet-2756	94	22	3-(3	3-(3	PROPN
admet-2756	94	23	-	-	PUNCT
admet-2756	94	24	bromopropoxy)benzaldehyde	bromopropoxy)benzaldehyde	PROPN
admet-2756	94	25	into	into	ADP
admet-2756	94	26	3-((3-(3-(1,3	3-((3-(3-(1,3	PROPN
admet-2756	94	27	-	-	PUNCT
admet-2756	94	28	dioxolan-2	dioxolan-2	NUM
admet-2756	94	29	-	-	PUNCT
admet-2756	94	30	yl)phenoxy	yl)phenoxy	VERB
admet-2756	94	31	)	)	PUNCT
admet-2756	94	32	propyl)(methyl	propyl)(methyl	NOUN
admet-2756	94	33	)	)	PUNCT
admet-2756	94	34	amino	amino	NOUN
admet-2756	94	35	)	)	PUNCT
admet-2756	94	36	propanoic	propanoic	ADJ
admet-2756	94	37	acid	acid	NOUN
admet-2756	94	38	.	.	PUNCT
admet-2756	95	1	in	in	ADP
admet-2756	95	2	the	the	DET
admet-2756	95	3	final	final	ADJ
admet-2756	95	4	step	step	NOUN
admet-2756	95	5	,	,	PUNCT
admet-2756	95	6	this	this	DET
admet-2756	95	7	compound	compound	NOUN
admet-2756	95	8	reacted	react	VERB
admet-2756	95	9	with	with	ADP
admet-2756	95	10	tris(trimethylsilyl	tris(trimethylsilyl	ADJ
admet-2756	95	11	)	)	PUNCT
admet-2756	95	12	phosphate	phosphate	NOUN
admet-2756	95	13	in	in	ADP
admet-2756	95	14	thf	thf	NOUN
admet-2756	95	15	under	under	ADP
admet-2756	95	16	an	an	DET
admet-2756	95	17	argon	argon	NOUN
admet-2756	95	18	atmosphere	atmosphere	NOUN
admet-2756	95	19	to	to	PART
admet-2756	95	20	yield	yield	VERB
admet-2756	95	21	bp-21	bp-21	NOUN
admet-2756	95	22	.	.	PUNCT
admet-2756	96	1	an	an	DET
admet-2756	96	2	outstanding	outstanding	ADJ
admet-2756	96	3	sustained	sustain	VERB
admet-2756	96	4	release	release	NOUN
admet-2756	96	5	profile	profile	NOUN
admet-2756	96	6	for	for	ADP
admet-2756	96	7	dox	dox	NOUN
admet-2756	96	8	was	be	AUX
admet-2756	96	9	offered	offer	VERB
admet-2756	96	10	by	by	ADP
admet-2756	96	11	12b80	12b80	NUM
admet-2756	96	12	.	.	PUNCT
admet-2756	97	1	less	less	ADJ
admet-2756	97	2	than	than	ADP
admet-2756	97	3	15	15	NUM
admet-2756	97	4	%	%	NOUN
admet-2756	97	5	of	of	ADP
admet-2756	97	6	the	the	DET
admet-2756	97	7	drug	drug	NOUN
admet-2756	97	8	was	be	AUX
admet-2756	97	9	released	release	VERB
admet-2756	97	10	after	after	ADP
admet-2756	97	11	3	3	NUM
admet-2756	97	12	days	day	NOUN
admet-2756	97	13	at	at	ADP
admet-2756	97	14	ph	ph	PROPN
admet-2756	97	15	4	4	NUM
admet-2756	97	16	.	.	PUNCT
admet-2756	98	1	under	under	ADP
admet-2756	98	2	physiological	physiological	ADJ
admet-2756	98	3	ph	ph	NOUN
admet-2756	98	4	,	,	PUNCT
admet-2756	98	5	it	it	PRON
admet-2756	98	6	was	be	AUX
admet-2756	98	7	less	less	ADJ
admet-2756	98	8	than	than	ADP
admet-2756	98	9	2	2	NUM
admet-2756	98	10	%	%	NOUN
admet-2756	98	11	.	.	PUNCT
admet-2756	99	1	in	in	ADP
admet-2756	99	2	vitro	vitro	X
admet-2756	99	3	binding	bind	VERB
admet-2756	99	4	of	of	ADP
admet-2756	99	5	12b80	12b80	NUM
admet-2756	99	6	to	to	ADP
admet-2756	99	7	hap	hap	NOUN
admet-2756	99	8	and	and	CCONJ
admet-2756	99	9	bovine	bovine	NOUN
admet-2756	99	10	bone	bone	NOUN
admet-2756	99	11	was	be	AUX
admet-2756	99	12	noticeably	noticeably	ADV
admet-2756	99	13	superior	superior	ADJ
admet-2756	99	14	to	to	ADP
admet-2756	99	15	free	free	ADJ
admet-2756	99	16	dox	dox	NOUN
admet-2756	99	17	.	.	PUNCT
admet-2756	100	1	similarly	similarly	ADV
admet-2756	100	2	,	,	PUNCT
admet-2756	100	3	much	much	ADV
admet-2756	100	4	higher	high	ADJ
admet-2756	100	5	levels	level	NOUN
admet-2756	100	6	of	of	ADP
admet-2756	100	7	12b80	12b80	NUM
admet-2756	100	8	than	than	ADP
admet-2756	100	9	free	free	ADJ
admet-2756	100	10	dox	dox	NOUN
admet-2756	100	11	accumulated	accumulate	VERB
admet-2756	100	12	in	in	ADP
admet-2756	100	13	the	the	DET
admet-2756	100	14	tibia	tibia	NOUN
admet-2756	100	15	and	and	CCONJ
admet-2756	100	16	tumour	tumour	NOUN
admet-2756	100	17	of	of	ADP
admet-2756	100	18	in	in	ADP
admet-2756	100	19	vivo	vivo	NOUN
admet-2756	100	20	animal	animal	NOUN
admet-2756	100	21	models	model	NOUN
admet-2756	100	22	.	.	PUNCT
admet-2756	101	1	figure	figure	NOUN
admet-2756	101	2	2	2	NUM
admet-2756	101	3	.	.	PUNCT
admet-2756	101	4	chemical	chemical	ADJ
admet-2756	101	5	structure	structure	NOUN
admet-2756	101	6	of	of	ADP
admet-2756	101	7	(	(	PUNCT
admet-2756	101	8	a	a	X
admet-2756	101	9	)	)	PUNCT
admet-2756	101	10	bp-21	bp-21	NOUN
admet-2756	101	11	(	(	PUNCT
admet-2756	101	12	b	b	NOUN
admet-2756	101	13	)	)	PUNCT
admet-2756	101	14	bp-15	bp-15	NOUN
admet-2756	101	15	(	(	PUNCT
admet-2756	101	16	c	c	NOUN
admet-2756	101	17	)	)	PUNCT
admet-2756	101	18	bp-22	bp-22	X
admet-2756	101	19	nadar	nadar	PROPN
admet-2756	101	20	et	et	PROPN
admet-2756	101	21	al	al	PROPN
admet-2756	101	22	.	.	PUNCT
admet-2756	102	1	[	[	X
admet-2756	102	2	17	17	NUM
admet-2756	102	3	]	]	PUNCT
admet-2756	102	4	developed	develop	VERB
admet-2756	102	5	a	a	DET
admet-2756	102	6	radioactive	radioactive	ADJ
admet-2756	102	7	complex	complex	NOUN
admet-2756	102	8	of	of	ADP
admet-2756	102	9	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	102	10	)	)	PUNCT
admet-2756	102	11	,	,	PUNCT
admet-2756	102	12	as	as	ADP
admet-2756	102	13	a	a	DET
admet-2756	102	14	platinum	platinum	NOUN
admet-2756	102	15	-	-	PUNCT
admet-2756	102	16	based	base	VERB
admet-2756	102	17	drug	drug	NOUN
admet-2756	102	18	and	and	CCONJ
admet-2756	102	19	2	2	NUM
admet-2756	102	20	-	-	PUNCT
admet-2756	102	21	amino1	amino1	NOUN
admet-2756	102	22	-	-	PUNCT
admet-2756	102	23	hydroxyethane-1,1	hydroxyethane-1,1	NOUN
admet-2756	102	24	-	-	PUNCT
admet-2756	102	25	diyl	diyl	NOUN
admet-2756	102	26	-	-	PUNCT
admet-2756	102	27	bisphosphonate	bisphosphonate	NOUN
admet-2756	102	28	(	(	PUNCT
admet-2756	102	29	bp-15	bp-15	NUM
admet-2756	102	30	)	)	PUNCT
admet-2756	102	31	(	(	PUNCT
admet-2756	102	32	figure	figure	NOUN
admet-2756	102	33	2b	2b	NOUN
admet-2756	102	34	)	)	PUNCT
admet-2756	102	35	,	,	PUNCT
admet-2756	102	36	as	as	ADP
admet-2756	102	37	the	the	DET
admet-2756	102	38	targeting	targeting	NOUN
admet-2756	102	39	ligand	ligand	NOUN
admet-2756	102	40	(	(	PUNCT
admet-2756	102	41	pt	pt	NOUN
admet-2756	102	42	-	-	PUNCT
admet-2756	102	43	bp	bp	NOUN
admet-2756	102	44	)	)	PUNCT
admet-2756	102	45	.	.	PUNCT
admet-2756	103	1	bp-15	bp-15	PUNCT
admet-2756	103	2	was	be	AUX
admet-2756	103	3	obtained	obtain	VERB
admet-2756	103	4	from	from	ADP
admet-2756	103	5	a	a	DET
admet-2756	103	6	3	3	NUM
admet-2756	103	7	-	-	PUNCT
admet-2756	103	8	step	step	NOUN
admet-2756	103	9	procedure	procedure	NOUN
admet-2756	103	10	,	,	PUNCT
admet-2756	103	11	starting	start	VERB
admet-2756	103	12	with	with	ADP
admet-2756	103	13	the	the	DET
admet-2756	103	14	reflux	reflux	NOUN
admet-2756	103	15	of	of	ADP
admet-2756	103	16	n	n	NOUN
admet-2756	103	17	-	-	PUNCT
admet-2756	103	18	phthaloylglycine	phthaloylglycine	NOUN
admet-2756	103	19	in	in	ADP
admet-2756	103	20	socl2	socl2	NOUN
admet-2756	103	21	,	,	PUNCT
admet-2756	103	22	followed	follow	VERB
admet-2756	103	23	by	by	ADP
admet-2756	103	24	a	a	DET
admet-2756	103	25	reaction	reaction	NOUN
admet-2756	103	26	with	with	ADP
admet-2756	103	27	tris(trimethylsilyl)phosphite	tris(trimethylsilyl)phosphite	PROPN
admet-2756	103	28	in	in	ADP
admet-2756	103	29	thf	thf	NOUN
admet-2756	103	30	,	,	PUNCT
admet-2756	103	31	ending	end	VERB
admet-2756	103	32	with	with	ADP
admet-2756	103	33	another	another	DET
admet-2756	103	34	reflux	reflux	NOUN
admet-2756	103	35	in	in	ADP
admet-2756	103	36	an	an	DET
admet-2756	103	37	aqueous	aqueous	ADJ
admet-2756	103	38	acidic	acidic	ADJ
admet-2756	103	39	solution	solution	NOUN
admet-2756	103	40	.	.	PUNCT
admet-2756	104	1	pt	pt	PROPN
admet-2756	104	2	-	-	PUNCT
admet-2756	104	3	bp	bp	PROPN
admet-2756	104	4	was	be	AUX
admet-2756	104	5	formed	form	VERB
admet-2756	104	6	via	via	ADP
admet-2756	104	7	ionic	ionic	ADJ
admet-2756	104	8	interaction	interaction	NOUN
admet-2756	104	9	between	between	ADP
admet-2756	104	10	the	the	DET
admet-2756	104	11	oh	oh	NUM
admet-2756	104	12	arms	arm	NOUN
admet-2756	104	13	of	of	ADP
admet-2756	104	14	bp-15	bp-15	NUM
admet-2756	104	15	and	and	CCONJ
admet-2756	104	16	the	the	DET
admet-2756	104	17	pt2	pt2	PROPN
admet-2756	104	18	+	+	PROPN
admet-2756	104	19	ion	ion	NOUN
admet-2756	104	20	.	.	PUNCT
admet-2756	105	1	in	in	ADP
admet-2756	105	2	vivo	vivo	ADJ
admet-2756	105	3	biodistribution	biodistribution	NOUN
admet-2756	105	4	studies	study	NOUN
admet-2756	105	5	were	be	AUX
admet-2756	105	6	conducted	conduct	VERB
admet-2756	105	7	on	on	ADP
admet-2756	105	8	mice	mouse	NOUN
admet-2756	105	9	to	to	PART
admet-2756	105	10	elucidate	elucidate	VERB
admet-2756	105	11	the	the	DET
admet-2756	105	12	targeting	target	VERB
admet-2756	105	13	functionality	functionality	NOUN
admet-2756	105	14	of	of	ADP
admet-2756	105	15	bp-15	bp-15	NOUN
admet-2756	105	16	.	.	PUNCT
admet-2756	106	1	very	very	ADV
admet-2756	106	2	low	low	ADJ
admet-2756	106	3	levels	level	NOUN
admet-2756	106	4	of	of	ADP
admet-2756	106	5	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	106	6	)	)	PUNCT
admet-2756	106	7	accumulated	accumulate	VERB
admet-2756	106	8	in	in	ADP
admet-2756	106	9	the	the	DET
admet-2756	106	10	tibia	tibia	NOUN
admet-2756	106	11	,	,	PUNCT
admet-2756	106	12	femur	femur	NOUN
admet-2756	106	13	,	,	PUNCT
admet-2756	106	14	humerus	humerus	NOUN
admet-2756	106	15	,	,	PUNCT
admet-2756	106	16	and	and	CCONJ
admet-2756	106	17	spine	spine	ADJ
admet-2756	106	18	,	,	PUNCT
admet-2756	106	19	whereas	whereas	SCONJ
admet-2756	106	20	pt	pt	PROPN
admet-2756	106	21	-	-	PUNCT
admet-2756	106	22	bp	bp	NOUN
admet-2756	106	23	accumulated	accumulate	VERB
admet-2756	106	24	significantly	significantly	ADV
admet-2756	106	25	in	in	ADP
admet-2756	106	26	these	these	DET
admet-2756	106	27	bones	bone	NOUN
admet-2756	106	28	,	,	PUNCT
admet-2756	106	29	which	which	PRON
admet-2756	106	30	confirmed	confirm	VERB
admet-2756	106	31	bp-15	bp-15	NOUN
admet-2756	106	32	’s	’s	PART
admet-2756	106	33	effective	effective	ADJ
admet-2756	106	34	targeting	targeting	NOUN
admet-2756	106	35	functionality	functionality	NOUN
admet-2756	106	36	.	.	PUNCT
admet-2756	107	1	moreover	moreover	ADV
admet-2756	107	2	,	,	PUNCT
admet-2756	107	3	pt	pt	PROPN
admet-2756	107	4	-	-	PUNCT
admet-2756	107	5	bp	bp	PROPN
admet-2756	107	6	was	be	AUX
admet-2756	107	7	excreted	excrete	VERB
admet-2756	107	8	from	from	ADP
admet-2756	107	9	soft	soft	ADJ
admet-2756	107	10	tissues	tissue	NOUN
admet-2756	107	11	over	over	ADP
admet-2756	107	12	72	72	NUM
admet-2756	107	13	h	h	NOUN
admet-2756	107	14	of	of	ADP
admet-2756	107	15	study	study	NOUN
admet-2756	107	16	,	,	PUNCT
admet-2756	107	17	whereas	whereas	SCONJ
admet-2756	107	18	the	the	DET
admet-2756	107	19	concentration	concentration	NOUN
admet-2756	107	20	of	of	ADP
admet-2756	107	21	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	107	22	)	)	PUNCT
admet-2756	107	23	in	in	ADP
admet-2756	107	24	soft	soft	ADJ
admet-2756	107	25	tissues	tissue	NOUN
admet-2756	107	26	remained	remain	VERB
admet-2756	107	27	constant	constant	ADJ
admet-2756	107	28	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	107	29	m.	m.	PROPN
admet-2756	107	30	eshaghi	eshaghi	PROPN
admet-2756	107	31	et	et	PROPN
admet-2756	107	32	al	al	PROPN
admet-2756	107	33	.	.	PROPN
admet-2756	107	34	admet	admet	PROPN
admet-2756	107	35	&	&	CCONJ
admet-2756	107	36	dmpk	dmpk	PROPN
admet-2756	107	37	13(3	13(3	NUM
admet-2756	107	38	)	)	PUNCT
admet-2756	107	39	(	(	PUNCT
admet-2756	107	40	2025	2025	NUM
admet-2756	107	41	)	)	PUNCT
admet-2756	107	42	2756	2756	NUM
admet-2756	107	43	6	6	NUM
admet-2756	107	44	in	in	ADP
admet-2756	107	45	this	this	DET
admet-2756	107	46	period	period	NOUN
admet-2756	107	47	.	.	PUNCT
admet-2756	108	1	this	this	DET
admet-2756	108	2	result	result	NOUN
admet-2756	108	3	promises	promise	VERB
admet-2756	108	4	the	the	DET
admet-2756	108	5	reduction	reduction	NOUN
admet-2756	108	6	of	of	ADP
admet-2756	108	7	side	side	NOUN
admet-2756	108	8	effects	effect	NOUN
admet-2756	108	9	from	from	ADP
admet-2756	108	10	the	the	DET
admet-2756	108	11	pt	pt	NOUN
admet-2756	108	12	-	-	PUNCT
admet-2756	108	13	based	base	VERB
admet-2756	108	14	drug	drug	NOUN
admet-2756	108	15	as	as	ADP
admet-2756	108	16	a	a	DET
admet-2756	108	17	result	result	NOUN
admet-2756	108	18	of	of	ADP
admet-2756	108	19	forming	form	VERB
admet-2756	108	20	a	a	DET
admet-2756	108	21	complex	complex	NOUN
admet-2756	108	22	with	with	ADP
admet-2756	108	23	bp-15	bp-15	NOUN
admet-2756	108	24	.	.	PUNCT
admet-2756	109	1	tao	tao	PROPN
admet-2756	109	2	et	et	PROPN
admet-2756	109	3	al	al	PROPN
admet-2756	109	4	.	.	PUNCT
admet-2756	110	1	[	[	X
admet-2756	110	2	24	24	NUM
admet-2756	110	3	]	]	PUNCT
admet-2756	110	4	used	use	VERB
admet-2756	110	5	three	three	NUM
admet-2756	110	6	different	different	ADJ
admet-2756	110	7	ph	ph	ADJ
admet-2756	110	8	-	-	ADJ
admet-2756	110	9	sensitive	sensitive	ADJ
admet-2756	110	10	linkers	linker	NOUN
admet-2756	110	11	to	to	PART
admet-2756	110	12	conjugate	conjugate	VERB
admet-2756	110	13	bortezomib	bortezomib	NOUN
admet-2756	110	14	(	(	PUNCT
admet-2756	110	15	btz	btz	PROPN
admet-2756	110	16	)	)	PUNCT
admet-2756	110	17	and	and	CCONJ
admet-2756	110	18	2-(bis(2	2-(bis(2	NOUN
admet-2756	110	19	-	-	PUNCT
admet-2756	110	20	hydroxyethyl)amino)ethyl(bis(diethoxyphosphoryl)methyl)carbamate	hydroxyethyl)amino)ethyl(bis(diethoxyphosphoryl)methyl)carbamate	NOUN
admet-2756	110	21	(	(	PUNCT
admet-2756	110	22	bp-22	bp-22	ADJ
admet-2756	110	23	)	)	PUNCT
admet-2756	110	24	for	for	ADP
admet-2756	110	25	treating	treat	VERB
admet-2756	110	26	multiple	multiple	ADJ
admet-2756	110	27	myeloma	myeloma	NOUN
admet-2756	110	28	(	(	PUNCT
admet-2756	110	29	bp	bp	PROPN
admet-2756	110	30	-	-	PUNCT
admet-2756	110	31	btz	btz	PROPN
admet-2756	110	32	)	)	PUNCT
admet-2756	110	33	.	.	PUNCT
admet-2756	111	1	the	the	DET
admet-2756	111	2	chemical	chemical	NOUN
admet-2756	111	3	structure	structure	NOUN
admet-2756	111	4	of	of	ADP
admet-2756	111	5	bp-22	bp-22	ADV
admet-2756	111	6	can	can	AUX
admet-2756	111	7	be	be	AUX
admet-2756	111	8	observed	observe	VERB
admet-2756	111	9	in	in	ADP
admet-2756	111	10	figure	figure	NOUN
admet-2756	111	11	2c	2c	NOUN
admet-2756	111	12	.	.	PUNCT
admet-2756	112	1	by	by	ADP
admet-2756	112	2	modifying	modify	VERB
admet-2756	112	3	the	the	DET
admet-2756	112	4	chemical	chemical	ADJ
admet-2756	112	5	structure	structure	NOUN
admet-2756	112	6	of	of	ADP
admet-2756	112	7	the	the	DET
admet-2756	112	8	linkers	linker	NOUN
admet-2756	112	9	,	,	PUNCT
admet-2756	112	10	the	the	DET
admet-2756	112	11	release	release	NOUN
admet-2756	112	12	rate	rate	NOUN
admet-2756	112	13	of	of	ADP
admet-2756	112	14	btz	btz	PROPN
admet-2756	112	15	was	be	AUX
admet-2756	112	16	perfectly	perfectly	ADV
admet-2756	112	17	modulated	modulate	VERB
admet-2756	112	18	.	.	PUNCT
admet-2756	113	1	a	a	DET
admet-2756	113	2	lead	lead	ADJ
admet-2756	113	3	candidate	candidate	NOUN
admet-2756	113	4	with	with	ADP
admet-2756	113	5	an	an	DET
admet-2756	113	6	optimum	optimum	ADJ
admet-2756	113	7	hydrolysis	hydrolysis	NOUN
admet-2756	113	8	-	-	PUNCT
admet-2756	113	9	mediated	mediate	VERB
admet-2756	113	10	release	release	NOUN
admet-2756	113	11	rate	rate	NOUN
admet-2756	113	12	was	be	AUX
admet-2756	113	13	selected	select	VERB
admet-2756	113	14	for	for	ADP
admet-2756	113	15	further	further	ADJ
admet-2756	113	16	study	study	NOUN
admet-2756	113	17	.	.	PUNCT
admet-2756	114	1	the	the	DET
admet-2756	114	2	selection	selection	NOUN
admet-2756	114	3	was	be	AUX
admet-2756	114	4	based	base	VERB
admet-2756	114	5	on	on	ADP
admet-2756	114	6	the	the	DET
admet-2756	114	7	superior	superior	ADJ
admet-2756	114	8	in	in	ADP
admet-2756	114	9	vivo	vivo	ADJ
admet-2756	114	10	antitumor	antitumor	NOUN
admet-2756	114	11	activity	activity	NOUN
admet-2756	114	12	compared	compare	VERB
admet-2756	114	13	with	with	ADP
admet-2756	114	14	the	the	DET
admet-2756	114	15	two	two	NUM
admet-2756	114	16	other	other	ADJ
admet-2756	114	17	candidates	candidate	NOUN
admet-2756	114	18	,	,	PUNCT
admet-2756	114	19	which	which	PRON
admet-2756	114	20	signifies	signify	VERB
admet-2756	114	21	the	the	DET
admet-2756	114	22	role	role	NOUN
admet-2756	114	23	of	of	ADP
admet-2756	114	24	release	release	NOUN
admet-2756	114	25	rate	rate	NOUN
admet-2756	114	26	in	in	ADP
admet-2756	114	27	therapeutic	therapeutic	ADJ
admet-2756	114	28	efficiency	efficiency	NOUN
admet-2756	114	29	.	.	PUNCT
admet-2756	115	1	bp-22	bp-22	PUNCT
admet-2756	115	2	increased	increase	VERB
admet-2756	115	3	the	the	DET
admet-2756	115	4	local	local	ADJ
admet-2756	115	5	concentration	concentration	NOUN
admet-2756	115	6	of	of	ADP
admet-2756	115	7	btz	btz	PROPN
admet-2756	115	8	in	in	ADP
admet-2756	115	9	bone	bone	NOUN
admet-2756	115	10	tissue	tissue	NOUN
admet-2756	115	11	and	and	CCONJ
admet-2756	115	12	prevented	prevent	VERB
admet-2756	115	13	quick	quick	ADJ
admet-2756	115	14	clearance	clearance	NOUN
admet-2756	115	15	from	from	ADP
admet-2756	115	16	bone	bone	NOUN
admet-2756	115	17	marrow	marrow	NOUN
admet-2756	115	18	by	by	ADP
admet-2756	115	19	the	the	DET
admet-2756	115	20	bloodstream	bloodstream	NOUN
admet-2756	115	21	.	.	PUNCT
admet-2756	116	1	additionally	additionally	ADV
admet-2756	116	2	,	,	PUNCT
admet-2756	116	3	this	this	DET
admet-2756	116	4	formulation	formulation	NOUN
admet-2756	116	5	offered	offer	VERB
admet-2756	116	6	the	the	DET
admet-2756	116	7	significant	significant	ADJ
admet-2756	116	8	advantage	advantage	NOUN
admet-2756	116	9	of	of	ADP
admet-2756	116	10	serum	serum	NOUN
admet-2756	116	11	stability	stability	NOUN
admet-2756	116	12	.	.	PUNCT
admet-2756	117	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	117	2	-	-	PUNCT
admet-2756	117	3	functionalized	functionalize	VERB
admet-2756	117	4	drug	drug	NOUN
admet-2756	117	5	delivery	delivery	NOUN
admet-2756	117	6	systems	system	NOUN
admet-2756	117	7	bisphosphonated	bisphosphonate	VERB
admet-2756	117	8	calcium	calcium	NOUN
admet-2756	117	9	-	-	PUNCT
admet-2756	117	10	based	base	VERB
admet-2756	117	11	systems	system	NOUN
admet-2756	117	12	research	research	NOUN
admet-2756	117	13	on	on	ADP
admet-2756	117	14	the	the	DET
admet-2756	117	15	biological	biological	ADJ
admet-2756	117	16	activity	activity	NOUN
admet-2756	117	17	of	of	ADP
admet-2756	117	18	calcium	calcium	NOUN
admet-2756	117	19	-	-	PUNCT
admet-2756	117	20	based	base	VERB
admet-2756	117	21	materials	material	NOUN
admet-2756	117	22	such	such	ADJ
admet-2756	117	23	as	as	ADP
admet-2756	117	24	hap	hap	NOUN
admet-2756	117	25	,	,	PUNCT
admet-2756	117	26	calcium	calcium	NOUN
admet-2756	117	27	phosphate	phosphate	NOUN
admet-2756	117	28	(	(	PUNCT
admet-2756	117	29	cp	cp	NOUN
admet-2756	117	30	)	)	PUNCT
admet-2756	117	31	,	,	PUNCT
admet-2756	117	32	and	and	CCONJ
admet-2756	117	33	bioactive	bioactive	ADJ
admet-2756	117	34	glass	glass	NOUN
admet-2756	117	35	(	(	PUNCT
admet-2756	117	36	bg	bg	NOUN
admet-2756	117	37	)	)	PUNCT
admet-2756	117	38	has	have	AUX
admet-2756	117	39	proven	prove	VERB
admet-2756	117	40	their	their	PRON
admet-2756	117	41	promising	promising	ADJ
admet-2756	117	42	application	application	NOUN
admet-2756	117	43	for	for	ADP
admet-2756	117	44	bone	bone	NOUN
admet-2756	117	45	regeneration	regeneration	NOUN
admet-2756	118	1	[	[	X
admet-2756	118	2	25	25	NUM
admet-2756	118	3	-	-	SYM
admet-2756	118	4	27	27	NUM
admet-2756	118	5	]	]	PUNCT
admet-2756	118	6	.	.	PUNCT
admet-2756	119	1	since	since	SCONJ
admet-2756	119	2	the	the	DET
admet-2756	119	3	density	density	NOUN
admet-2756	119	4	of	of	ADP
admet-2756	119	5	cancerous	cancerous	ADJ
admet-2756	119	6	bone	bone	NOUN
admet-2756	119	7	tissue	tissue	NOUN
admet-2756	119	8	is	be	AUX
admet-2756	119	9	seriously	seriously	ADV
admet-2756	119	10	compromised	compromise	VERB
admet-2756	119	11	as	as	ADP
admet-2756	119	12	a	a	DET
admet-2756	119	13	result	result	NOUN
admet-2756	119	14	of	of	ADP
admet-2756	119	15	osteoclast	osteoclast	ADJ
admet-2756	119	16	cells	cell	NOUN
admet-2756	119	17	’	'	PUNCT
admet-2756	119	18	stimulation	stimulation	NOUN
admet-2756	119	19	by	by	ADP
admet-2756	119	20	tumour	tumour	NOUN
admet-2756	119	21	cells	cell	NOUN
admet-2756	119	22	,	,	PUNCT
admet-2756	119	23	using	use	VERB
admet-2756	119	24	such	such	ADJ
admet-2756	119	25	materials	material	NOUN
admet-2756	119	26	as	as	ADP
admet-2756	119	27	a	a	DET
admet-2756	119	28	drug	drug	NOUN
admet-2756	119	29	delivery	delivery	NOUN
admet-2756	119	30	system	system	NOUN
admet-2756	119	31	for	for	ADP
admet-2756	119	32	anticancer	anticancer	NOUN
admet-2756	119	33	drugs	drug	NOUN
admet-2756	119	34	is	be	AUX
admet-2756	119	35	a	a	DET
admet-2756	119	36	promising	promising	ADJ
admet-2756	119	37	solution	solution	NOUN
admet-2756	119	38	for	for	ADP
admet-2756	119	39	the	the	DET
admet-2756	119	40	parallel	parallel	ADJ
admet-2756	119	41	treatment	treatment	NOUN
admet-2756	119	42	of	of	ADP
admet-2756	119	43	bone	bone	NOUN
admet-2756	119	44	tumours	tumour	NOUN
admet-2756	119	45	and	and	CCONJ
admet-2756	119	46	bone	bone	NOUN
admet-2756	119	47	regeneration	regeneration	NOUN
admet-2756	119	48	.	.	PUNCT
admet-2756	120	1	li	li	PROPN
admet-2756	120	2	et	et	PROPN
admet-2756	120	3	al	al	PROPN
admet-2756	120	4	.	.	PUNCT
admet-2756	121	1	[	[	X
admet-2756	121	2	28	28	NUM
admet-2756	121	3	]	]	PUNCT
admet-2756	121	4	used	use	VERB
admet-2756	121	5	ibuprofen	ibuprofen	NOUN
admet-2756	121	6	as	as	ADP
admet-2756	121	7	a	a	DET
admet-2756	121	8	model	model	NOUN
admet-2756	121	9	drug	drug	NOUN
admet-2756	121	10	for	for	ADP
admet-2756	121	11	assessing	assess	VERB
admet-2756	121	12	aln	aln	PROPN
admet-2756	121	13	-	-	PUNCT
admet-2756	121	14	conjugated	conjugate	VERB
admet-2756	121	15	hap	hap	PROPN
admet-2756	121	16	nanoparticles	nanoparticle	NOUN
admet-2756	121	17	(	(	PUNCT
admet-2756	121	18	nps	nps	PROPN
admet-2756	121	19	)	)	PUNCT
admet-2756	121	20	as	as	ADP
admet-2756	121	21	a	a	DET
admet-2756	121	22	drug	drug	NOUN
admet-2756	121	23	delivery	delivery	NOUN
admet-2756	121	24	system	system	NOUN
admet-2756	121	25	.	.	PUNCT
admet-2756	122	1	compared	compare	VERB
admet-2756	122	2	to	to	ADP
admet-2756	122	3	naked	naked	PROPN
admet-2756	122	4	hap	hap	PROPN
admet-2756	122	5	nps	nps	PROPN
admet-2756	122	6	,	,	PUNCT
admet-2756	122	7	aln	aln	PROPN
admet-2756	122	8	-	-	PUNCT
admet-2756	122	9	modified	modify	VERB
admet-2756	122	10	nps	nps	PROPN
admet-2756	122	11	could	could	AUX
admet-2756	122	12	encapsulate	encapsulate	VERB
admet-2756	122	13	considerably	considerably	ADV
admet-2756	122	14	higher	high	ADJ
admet-2756	122	15	amounts	amount	NOUN
admet-2756	122	16	of	of	ADP
admet-2756	122	17	the	the	DET
admet-2756	122	18	drug	drug	NOUN
admet-2756	122	19	,	,	PUNCT
admet-2756	122	20	which	which	PRON
admet-2756	122	21	can	can	AUX
admet-2756	122	22	be	be	AUX
admet-2756	122	23	attributed	attribute	VERB
admet-2756	122	24	to	to	ADP
admet-2756	122	25	the	the	DET
admet-2756	122	26	ionic	ionic	ADJ
admet-2756	122	27	affinity	affinity	NOUN
admet-2756	122	28	between	between	ADP
admet-2756	122	29	amine	amine	ADJ
admet-2756	122	30	groups	group	NOUN
admet-2756	122	31	of	of	ADP
admet-2756	122	32	aln	aln	PROPN
admet-2756	122	33	and	and	CCONJ
admet-2756	122	34	carboxyl	carboxyl	NOUN
admet-2756	122	35	groups	group	NOUN
admet-2756	122	36	of	of	ADP
admet-2756	122	37	ibuprofen	ibuprofen	PROPN
admet-2756	122	38	(	(	PUNCT
admet-2756	122	39	ibf	ibf	PROPN
admet-2756	122	40	)	)	PUNCT
admet-2756	122	41	.	.	PUNCT
admet-2756	123	1	however	however	ADV
admet-2756	123	2	,	,	PUNCT
admet-2756	123	3	ibuprofen	ibuprofen	PROPN
admet-2756	123	4	experienced	experience	VERB
admet-2756	123	5	a	a	DET
admet-2756	123	6	huge	huge	ADJ
admet-2756	123	7	burst	burst	NOUN
admet-2756	123	8	release	release	NOUN
admet-2756	123	9	(	(	PUNCT
admet-2756	123	10	more	more	ADJ
admet-2756	123	11	than	than	ADP
admet-2756	123	12	90	90	NUM
admet-2756	123	13	%	%	NOUN
admet-2756	123	14	)	)	PUNCT
admet-2756	123	15	after	after	ADP
admet-2756	123	16	just	just	ADV
admet-2756	123	17	3	3	NUM
admet-2756	123	18	hours	hour	NOUN
admet-2756	123	19	of	of	ADP
admet-2756	123	20	the	the	DET
admet-2756	123	21	in	in	ADP
admet-2756	123	22	vitro	vitro	X
admet-2756	123	23	experiment	experiment	NOUN
admet-2756	123	24	.	.	PUNCT
admet-2756	124	1	this	this	DET
admet-2756	124	2	burst	burst	ADJ
admet-2756	124	3	release	release	NOUN
admet-2756	124	4	can	can	AUX
admet-2756	124	5	be	be	AUX
admet-2756	124	6	associated	associate	VERB
admet-2756	124	7	with	with	ADP
admet-2756	124	8	the	the	DET
admet-2756	124	9	fact	fact	NOUN
admet-2756	124	10	that	that	SCONJ
admet-2756	124	11	a	a	DET
admet-2756	124	12	hydrophobic	hydrophobic	NOUN
admet-2756	124	13	drug	drug	NOUN
admet-2756	124	14	was	be	AUX
admet-2756	124	15	encapsulated	encapsulate	VERB
admet-2756	124	16	in	in	ADP
admet-2756	124	17	polar	polar	PROPN
admet-2756	124	18	hap	hap	PROPN
admet-2756	124	19	nps	nps	PROPN
admet-2756	124	20	.	.	PUNCT
admet-2756	125	1	chu	chu	PROPN
admet-2756	125	2	et	et	PROPN
admet-2756	125	3	al	al	PROPN
admet-2756	125	4	.	.	PUNCT
admet-2756	126	1	[	[	X
admet-2756	126	2	29	29	NUM
admet-2756	126	3	]	]	X
admet-2756	126	4	modified	modify	VERB
admet-2756	126	5	cp	cp	PROPN
admet-2756	126	6	nps	nps	PROPN
admet-2756	126	7	using	use	VERB
admet-2756	126	8	an	an	DET
admet-2756	126	9	aln	aln	PROPN
admet-2756	126	10	-	-	PUNCT
admet-2756	126	11	conjugated	conjugate	VERB
admet-2756	126	12	polyethylene	polyethylene	NOUN
admet-2756	126	13	glycol	glycol	NOUN
admet-2756	126	14	(	(	PUNCT
admet-2756	126	15	peg	peg	NOUN
admet-2756	126	16	)	)	PUNCT
admet-2756	126	17	moiety	moiety	NOUN
admet-2756	126	18	for	for	ADP
admet-2756	126	19	delivering	deliver	VERB
admet-2756	126	20	methotrexate	methotrexate	NOUN
admet-2756	126	21	(	(	PUNCT
admet-2756	126	22	mtx	mtx	NOUN
admet-2756	126	23	)	)	PUNCT
admet-2756	126	24	,	,	PUNCT
admet-2756	126	25	an	an	DET
admet-2756	126	26	anticancer	anticancer	NOUN
admet-2756	126	27	drug	drug	NOUN
admet-2756	126	28	,	,	PUNCT
admet-2756	126	29	to	to	ADP
admet-2756	126	30	tumour	tumour	NOUN
admet-2756	126	31	-	-	PUNCT
admet-2756	126	32	bearing	bear	VERB
admet-2756	126	33	bone	bone	NOUN
admet-2756	126	34	.	.	PUNCT
admet-2756	127	1	due	due	ADP
admet-2756	127	2	to	to	ADP
admet-2756	127	3	the	the	DET
admet-2756	127	4	acid	acid	NOUN
admet-2756	127	5	-	-	PUNCT
admet-2756	127	6	sensitive	sensitive	ADJ
admet-2756	127	7	structure	structure	NOUN
admet-2756	127	8	of	of	ADP
admet-2756	127	9	cp	cp	PROPN
admet-2756	127	10	nps	nps	PROPN
admet-2756	127	11	,	,	PUNCT
admet-2756	127	12	about	about	ADV
admet-2756	127	13	90	90	NUM
admet-2756	127	14	%	%	NOUN
admet-2756	127	15	of	of	ADP
admet-2756	127	16	the	the	DET
admet-2756	127	17	payload	payload	NOUN
admet-2756	127	18	was	be	AUX
admet-2756	127	19	released	release	VERB
admet-2756	127	20	under	under	ADP
admet-2756	127	21	acidic	acidic	ADJ
admet-2756	127	22	conditions	condition	NOUN
admet-2756	127	23	(	(	PUNCT
admet-2756	127	24	ph	ph	NOUN
admet-2756	127	25	4.7	4.7	NUM
admet-2756	127	26	)	)	PUNCT
admet-2756	127	27	in	in	ADP
admet-2756	127	28	the	the	DET
admet-2756	127	29	first	first	ADJ
admet-2756	127	30	3	3	NUM
admet-2756	127	31	hours	hour	NOUN
admet-2756	127	32	,	,	PUNCT
admet-2756	127	33	followed	follow	VERB
admet-2756	127	34	by	by	ADP
admet-2756	127	35	a	a	DET
admet-2756	127	36	steady	steady	ADJ
admet-2756	127	37	pattern	pattern	NOUN
admet-2756	127	38	in	in	ADP
admet-2756	127	39	the	the	DET
admet-2756	127	40	remaining	remain	VERB
admet-2756	127	41	21	21	NUM
admet-2756	127	42	hours	hour	NOUN
admet-2756	127	43	.	.	PUNCT
admet-2756	128	1	regarding	regard	VERB
admet-2756	128	2	bone	bone	NOUN
admet-2756	128	3	targeting	target	VERB
admet-2756	128	4	properties	property	NOUN
admet-2756	128	5	,	,	PUNCT
admet-2756	128	6	the	the	DET
admet-2756	128	7	affinity	affinity	NOUN
admet-2756	128	8	of	of	ADP
admet-2756	128	9	nps	nps	PROPN
admet-2756	128	10	for	for	ADP
admet-2756	128	11	bone	bone	NOUN
admet-2756	128	12	positively	positively	ADV
admet-2756	128	13	correlated	correlate	VERB
admet-2756	128	14	with	with	ADP
admet-2756	128	15	the	the	DET
admet-2756	128	16	amount	amount	NOUN
admet-2756	128	17	of	of	ADP
admet-2756	128	18	aln	aln	NOUN
admet-2756	128	19	used	use	VERB
admet-2756	128	20	in	in	ADP
admet-2756	128	21	the	the	DET
admet-2756	128	22	formulation	formulation	NOUN
admet-2756	128	23	.	.	PUNCT
admet-2756	129	1	in	in	ADP
admet-2756	129	2	another	another	DET
admet-2756	129	3	study	study	NOUN
admet-2756	129	4	,	,	PUNCT
admet-2756	129	5	mehnath	mehnath	PROPN
admet-2756	129	6	et	et	PROPN
admet-2756	129	7	al	al	PROPN
admet-2756	129	8	.	.	PUNCT
admet-2756	130	1	[	[	X
admet-2756	130	2	30	30	NUM
admet-2756	130	3	]	]	PUNCT
admet-2756	130	4	functionalized	functionalized	ADJ
admet-2756	130	5	dox	dox	NOUN
admet-2756	130	6	-	-	PUNCT
admet-2756	130	7	loaded	load	VERB
admet-2756	130	8	bg	bg	PROPN
admet-2756	130	9	nps	nps	PROPN
admet-2756	130	10	with	with	ADP
admet-2756	130	11	hyaluronic	hyaluronic	ADJ
admet-2756	130	12	acid	acid	NOUN
admet-2756	130	13	(	(	PUNCT
admet-2756	130	14	ha)-aln	ha)-aln	NOUN
admet-2756	130	15	conjugate	conjugate	VERB
admet-2756	130	16	.	.	PUNCT
admet-2756	131	1	in	in	ADP
admet-2756	131	2	vitro	vitro	X
admet-2756	131	3	release	release	NOUN
admet-2756	131	4	experiments	experiment	NOUN
admet-2756	131	5	in	in	ADP
admet-2756	131	6	acidic	acidic	ADJ
admet-2756	131	7	(	(	PUNCT
admet-2756	131	8	ph	ph	NOUN
admet-2756	131	9	4.5	4.5	NUM
admet-2756	131	10	)	)	PUNCT
admet-2756	131	11	and	and	CCONJ
admet-2756	131	12	neutral	neutral	ADJ
admet-2756	131	13	(	(	PUNCT
admet-2756	131	14	ph	ph	NOUN
admet-2756	131	15	=	=	NOUN
admet-2756	131	16	7.4	7.4	NUM
admet-2756	131	17	)	)	PUNCT
admet-2756	131	18	environments	environment	NOUN
admet-2756	131	19	revealed	reveal	VERB
admet-2756	131	20	acidsensitivity	acidsensitivity	NOUN
admet-2756	131	21	of	of	ADP
admet-2756	131	22	the	the	DET
admet-2756	131	23	nps	nps	PROPN
admet-2756	131	24	.	.	PUNCT
admet-2756	132	1	under	under	ADP
admet-2756	132	2	acidic	acidic	ADJ
admet-2756	132	3	conditions	condition	NOUN
admet-2756	132	4	,	,	PUNCT
admet-2756	132	5	nps	nps	PROPN
admet-2756	132	6	released	release	VERB
admet-2756	132	7	no	no	DET
admet-2756	132	8	more	more	ADJ
admet-2756	132	9	than	than	ADP
admet-2756	132	10	65	65	NUM
admet-2756	132	11	%	%	NOUN
admet-2756	132	12	of	of	ADP
admet-2756	132	13	dox	dox	NOUN
admet-2756	132	14	and	and	CCONJ
admet-2756	132	15	after	after	ADP
admet-2756	132	16	48	48	NUM
admet-2756	132	17	hours	hour	NOUN
admet-2756	132	18	,	,	PUNCT
admet-2756	132	19	no	no	DET
admet-2756	132	20	more	more	ADJ
admet-2756	132	21	drug	drug	NOUN
admet-2756	132	22	was	be	AUX
admet-2756	132	23	released	release	VERB
admet-2756	132	24	.	.	PUNCT
admet-2756	133	1	in	in	ADP
admet-2756	133	2	vitro	vitro	X
admet-2756	133	3	hap	hap	X
admet-2756	133	4	binding	bind	VERB
admet-2756	133	5	assay	assay	PROPN
admet-2756	133	6	revealed	reveal	VERB
admet-2756	133	7	a	a	DET
admet-2756	133	8	boosted	boosted	ADJ
admet-2756	133	9	affinity	affinity	NOUN
admet-2756	133	10	of	of	ADP
admet-2756	133	11	nps	nps	PROPN
admet-2756	133	12	to	to	ADP
admet-2756	133	13	hap	hap	VERB
admet-2756	133	14	after	after	ADP
admet-2756	133	15	the	the	DET
admet-2756	133	16	inclusion	inclusion	NOUN
admet-2756	133	17	of	of	ADP
admet-2756	133	18	aln	aln	PROPN
admet-2756	133	19	in	in	ADP
admet-2756	133	20	the	the	DET
admet-2756	133	21	formulation	formulation	NOUN
admet-2756	133	22	.	.	PUNCT
admet-2756	134	1	hap	hap	PROPN
admet-2756	134	2	binding	binding	PROPN
admet-2756	134	3	increased	increase	VERB
admet-2756	134	4	4	4	NUM
admet-2756	134	5	times	time	NOUN
admet-2756	134	6	for	for	ADP
admet-2756	134	7	aln	aln	PROPN
admet-2756	134	8	-	-	PUNCT
admet-2756	134	9	modified	modify	VERB
admet-2756	134	10	nps	nps	PROPN
admet-2756	134	11	compared	compare	VERB
admet-2756	134	12	with	with	ADP
admet-2756	134	13	naked	naked	PROPN
admet-2756	134	14	nps	nps	PROPN
admet-2756	134	15	after	after	ADP
admet-2756	134	16	2.5	2.5	NUM
admet-2756	134	17	hours	hour	NOUN
admet-2756	134	18	of	of	ADP
admet-2756	134	19	incubation	incubation	NOUN
admet-2756	134	20	.	.	PUNCT
admet-2756	135	1	in	in	ADP
admet-2756	135	2	vitro	vitro	X
admet-2756	135	3	cytotoxicity	cytotoxicity	NOUN
admet-2756	135	4	assay	assay	NOUN
admet-2756	135	5	revealed	reveal	VERB
admet-2756	135	6	time	time	NOUN
admet-2756	135	7	and	and	CCONJ
admet-2756	135	8	dose	dose	NOUN
admet-2756	135	9	-	-	PUNCT
admet-2756	135	10	dependent	dependent	ADJ
admet-2756	135	11	toxicity	toxicity	NOUN
admet-2756	135	12	of	of	ADP
admet-2756	135	13	dox	dox	NOUN
admet-2756	135	14	-	-	PUNCT
admet-2756	135	15	loaded	load	VERB
admet-2756	135	16	bg	bg	PROPN
admet-2756	135	17	nps	nps	PROPN
admet-2756	135	18	on	on	ADP
admet-2756	135	19	the	the	DET
admet-2756	135	20	mg-63	mg-63	NOUN
admet-2756	135	21	cell	cell	NOUN
admet-2756	135	22	line	line	NOUN
admet-2756	135	23	.	.	PUNCT
admet-2756	136	1	dox	dox	NOUN
admet-2756	136	2	-	-	PUNCT
admet-2756	136	3	loaded	load	VERB
admet-2756	136	4	nps	nps	PROPN
admet-2756	136	5	were	be	AUX
admet-2756	136	6	superior	superior	ADJ
admet-2756	136	7	to	to	ADP
admet-2756	136	8	free	free	ADJ
admet-2756	136	9	dox	dox	NOUN
admet-2756	136	10	in	in	ADP
admet-2756	136	11	terms	term	NOUN
admet-2756	136	12	of	of	ADP
admet-2756	136	13	cytotoxicity	cytotoxicity	NOUN
admet-2756	136	14	in	in	ADP
admet-2756	136	15	all	all	DET
admet-2756	136	16	concentrations	concentration	NOUN
admet-2756	136	17	.	.	PUNCT
admet-2756	137	1	also	also	ADV
admet-2756	137	2	,	,	PUNCT
admet-2756	137	3	as	as	SCONJ
admet-2756	137	4	the	the	DET
admet-2756	137	5	concentration	concentration	NOUN
admet-2756	137	6	increased	increase	VERB
admet-2756	137	7	,	,	PUNCT
admet-2756	137	8	this	this	DET
admet-2756	137	9	superiority	superiority	NOUN
admet-2756	137	10	became	become	VERB
admet-2756	137	11	more	more	ADV
admet-2756	137	12	noticeable	noticeable	ADJ
admet-2756	137	13	.	.	PUNCT
admet-2756	138	1	hap	hap	PROPN
admet-2756	138	2	and	and	CCONJ
admet-2756	138	3	cp	cp	PROPN
admet-2756	138	4	have	have	VERB
admet-2756	138	5	similar	similar	ADJ
admet-2756	138	6	composition	composition	NOUN
admet-2756	138	7	,	,	PUNCT
admet-2756	138	8	and	and	CCONJ
admet-2756	138	9	both	both	PRON
admet-2756	138	10	are	be	AUX
admet-2756	138	11	labile	labile	ADJ
admet-2756	138	12	to	to	ADP
admet-2756	138	13	acidic	acidic	ADJ
admet-2756	138	14	conditions	condition	NOUN
admet-2756	138	15	.	.	PUNCT
admet-2756	139	1	according	accord	VERB
admet-2756	139	2	to	to	ADP
admet-2756	139	3	the	the	DET
admet-2756	139	4	reviewed	review	VERB
admet-2756	139	5	literature	literature	NOUN
admet-2756	139	6	,	,	PUNCT
admet-2756	139	7	it	it	PRON
admet-2756	139	8	can	can	AUX
admet-2756	139	9	be	be	AUX
admet-2756	139	10	concluded	conclude	VERB
admet-2756	139	11	that	that	SCONJ
admet-2756	139	12	nanostructures	nanostructure	NOUN
admet-2756	139	13	based	base	VERB
admet-2756	139	14	on	on	ADP
admet-2756	139	15	these	these	DET
admet-2756	139	16	materials	material	NOUN
admet-2756	139	17	would	would	AUX
admet-2756	139	18	readily	readily	ADV
admet-2756	139	19	collapse	collapse	VERB
admet-2756	139	20	in	in	ADP
admet-2756	139	21	acidic	acidic	ADJ
admet-2756	139	22	conditions	condition	NOUN
admet-2756	139	23	and	and	CCONJ
admet-2756	139	24	release	release	VERB
admet-2756	139	25	their	their	PRON
admet-2756	139	26	payload	payload	NOUN
admet-2756	139	27	abruptly	abruptly	ADV
admet-2756	139	28	[	[	X
admet-2756	139	29	28,29	28,29	NUM
admet-2756	139	30	]	]	PUNCT
admet-2756	139	31	.	.	PUNCT
admet-2756	140	1	on	on	ADP
admet-2756	140	2	the	the	DET
admet-2756	140	3	contrary	contrary	NOUN
admet-2756	140	4	,	,	PUNCT
admet-2756	140	5	bg	bg	PROPN
admet-2756	140	6	,	,	PUNCT
admet-2756	140	7	which	which	PRON
admet-2756	140	8	has	have	VERB
admet-2756	140	9	a	a	DET
admet-2756	140	10	different	different	ADJ
admet-2756	140	11	composition	composition	NOUN
admet-2756	140	12	than	than	ADP
admet-2756	140	13	hap	hap	NOUN
admet-2756	140	14	and	and	CCONJ
admet-2756	140	15	cp	cp	NOUN
admet-2756	140	16	,	,	PUNCT
admet-2756	140	17	was	be	AUX
admet-2756	140	18	shown	show	VERB
admet-2756	140	19	to	to	PART
admet-2756	140	20	be	be	AUX
admet-2756	140	21	less	less	ADV
admet-2756	140	22	labile	labile	ADJ
admet-2756	140	23	to	to	ADP
admet-2756	140	24	ph	ph	ADJ
admet-2756	140	25	alterations	alteration	NOUN
admet-2756	140	26	and	and	CCONJ
admet-2756	140	27	managed	manage	VERB
admet-2756	140	28	to	to	PART
admet-2756	140	29	maintain	maintain	VERB
admet-2756	140	30	a	a	DET
admet-2756	140	31	more	more	ADV
admet-2756	140	32	sustained	sustained	ADJ
admet-2756	140	33	admet	admet	NOUN
admet-2756	140	34	&	&	CCONJ
admet-2756	140	35	dmpk	dmpk	PROPN
admet-2756	140	36	13(3	13(3	NUM
admet-2756	140	37	)	)	PUNCT
admet-2756	140	38	(	(	PUNCT
admet-2756	140	39	2025	2025	NUM
admet-2756	140	40	)	)	PUNCT
admet-2756	140	41	2756	2756	NUM
admet-2756	140	42	bisphosphonates	bisphosphonate	NOUN
admet-2756	140	43	for	for	ADP
admet-2756	140	44	bone	bone	NOUN
admet-2756	140	45	cancer	cancer	NOUN
admet-2756	140	46	therapy	therapy	NOUN
admet-2756	140	47	doi	doi	NOUN
admet-2756	140	48	:	:	PUNCT
admet-2756	140	49	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	140	50	7	7	NUM
admet-2756	140	51	release	release	NOUN
admet-2756	140	52	profile	profile	NOUN
admet-2756	140	53	for	for	ADP
admet-2756	140	54	its	its	PRON
admet-2756	140	55	payload	payload	NOUN
admet-2756	141	1	[	[	X
admet-2756	141	2	30	30	NUM
admet-2756	141	3	]	]	PUNCT
admet-2756	141	4	.	.	PUNCT
admet-2756	142	1	this	this	DET
admet-2756	142	2	outcome	outcome	NOUN
admet-2756	142	3	can	can	AUX
admet-2756	142	4	be	be	AUX
admet-2756	142	5	attributed	attribute	VERB
admet-2756	142	6	to	to	ADP
admet-2756	142	7	the	the	DET
admet-2756	142	8	difference	difference	NOUN
admet-2756	142	9	between	between	ADP
admet-2756	142	10	the	the	DET
admet-2756	142	11	chemical	chemical	NOUN
admet-2756	142	12	composition	composition	NOUN
admet-2756	142	13	of	of	ADP
admet-2756	142	14	bg	bg	PROPN
admet-2756	142	15	,	,	PUNCT
admet-2756	142	16	hap	hap	NOUN
admet-2756	142	17	,	,	PUNCT
admet-2756	142	18	and	and	CCONJ
admet-2756	142	19	cp	cp	INTJ
admet-2756	142	20	as	as	SCONJ
admet-2756	142	21	depicted	depict	VERB
admet-2756	142	22	in	in	ADP
admet-2756	142	23	figure	figure	NOUN
admet-2756	142	24	3	3	NUM
admet-2756	142	25	.	.	PUNCT
admet-2756	142	26	figure	figure	NOUN
admet-2756	142	27	3	3	NUM
admet-2756	142	28	.	.	PUNCT
admet-2756	143	1	the	the	DET
admet-2756	143	2	lower	low	ADJ
admet-2756	143	3	sensitivity	sensitivity	NOUN
admet-2756	143	4	of	of	ADP
admet-2756	143	5	bg	bg	NOUN
admet-2756	143	6	to	to	ADP
admet-2756	143	7	the	the	DET
admet-2756	143	8	acidic	acidic	ADJ
admet-2756	143	9	environment	environment	NOUN
admet-2756	143	10	compared	compare	VERB
admet-2756	143	11	with	with	ADP
admet-2756	143	12	cp	cp	NUM
admet-2756	143	13	and	and	CCONJ
admet-2756	143	14	hap	hap	PROPN
admet-2756	143	15	a	a	DET
admet-2756	143	16	sustained	sustain	VERB
admet-2756	143	17	release	release	NOUN
admet-2756	143	18	profile	profile	NOUN
admet-2756	143	19	is	be	AUX
admet-2756	143	20	crucial	crucial	ADJ
admet-2756	143	21	for	for	ADP
admet-2756	143	22	enhancing	enhance	VERB
admet-2756	143	23	the	the	DET
admet-2756	143	24	therapeutic	therapeutic	ADJ
admet-2756	143	25	efficiency	efficiency	NOUN
admet-2756	143	26	of	of	ADP
admet-2756	143	27	drug	drug	NOUN
admet-2756	143	28	delivery	delivery	NOUN
admet-2756	143	29	systems	system	NOUN
admet-2756	143	30	in	in	ADP
admet-2756	143	31	tumour	tumour	NOUN
admet-2756	143	32	therapy	therapy	NOUN
admet-2756	143	33	.	.	PUNCT
admet-2756	144	1	considering	consider	VERB
admet-2756	144	2	these	these	DET
admet-2756	144	3	factors	factor	NOUN
admet-2756	144	4	,	,	PUNCT
admet-2756	144	5	bg	bg	PROPN
admet-2756	144	6	stands	stand	VERB
admet-2756	144	7	out	out	ADP
admet-2756	144	8	as	as	ADP
admet-2756	144	9	a	a	DET
admet-2756	144	10	more	more	ADV
admet-2756	144	11	suitable	suitable	ADJ
admet-2756	144	12	candidate	candidate	NOUN
admet-2756	144	13	among	among	ADP
admet-2756	144	14	the	the	DET
admet-2756	144	15	studied	study	VERB
admet-2756	144	16	calcium	calcium	NOUN
admet-2756	144	17	-	-	PUNCT
admet-2756	144	18	based	base	VERB
admet-2756	144	19	materials	material	NOUN
admet-2756	144	20	for	for	ADP
admet-2756	144	21	drug	drug	NOUN
admet-2756	144	22	delivery	delivery	NOUN
admet-2756	144	23	applications	application	NOUN
admet-2756	144	24	where	where	SCONJ
admet-2756	144	25	a	a	DET
admet-2756	144	26	sustained	sustained	ADJ
admet-2756	144	27	release	release	NOUN
admet-2756	144	28	profile	profile	NOUN
admet-2756	144	29	is	be	AUX
admet-2756	144	30	preferred	prefer	VERB
admet-2756	144	31	.	.	PUNCT
admet-2756	145	1	besides	besides	SCONJ
admet-2756	145	2	the	the	DET
admet-2756	145	3	acid	acid	NOUN
admet-2756	145	4	-	-	PUNCT
admet-2756	145	5	sensitive	sensitive	ADJ
admet-2756	145	6	structure	structure	NOUN
admet-2756	145	7	of	of	ADP
admet-2756	145	8	ca	ca	NOUN
admet-2756	145	9	-	-	PUNCT
admet-2756	145	10	based	base	VERB
admet-2756	145	11	nps	nps	PROPN
admet-2756	145	12	,	,	PUNCT
admet-2756	145	13	another	another	DET
admet-2756	145	14	reason	reason	NOUN
admet-2756	145	15	for	for	ADP
admet-2756	145	16	burst	burst	ADJ
admet-2756	145	17	release	release	NOUN
admet-2756	145	18	in	in	ADP
admet-2756	145	19	acidic	acidic	ADJ
admet-2756	145	20	conditions	condition	NOUN
admet-2756	145	21	is	be	AUX
admet-2756	145	22	that	that	SCONJ
admet-2756	145	23	many	many	ADJ
admet-2756	145	24	studies	study	NOUN
admet-2756	145	25	have	have	AUX
admet-2756	145	26	attempted	attempt	VERB
admet-2756	145	27	to	to	PART
admet-2756	145	28	encapsulate	encapsulate	VERB
admet-2756	145	29	hydrophobic	hydrophobic	NOUN
admet-2756	145	30	drugs	drug	NOUN
admet-2756	145	31	in	in	ADP
admet-2756	145	32	such	such	ADJ
admet-2756	145	33	hydrophilic	hydrophilic	ADJ
admet-2756	145	34	structures	structure	NOUN
admet-2756	145	35	.	.	PUNCT
admet-2756	146	1	table	table	NOUN
admet-2756	146	2	4	4	NUM
admet-2756	146	3	illustrates	illustrate	VERB
admet-2756	146	4	the	the	DET
admet-2756	146	5	correlation	correlation	NOUN
admet-2756	146	6	between	between	ADP
admet-2756	146	7	the	the	DET
admet-2756	146	8	chemical	chemical	NOUN
admet-2756	146	9	structure	structure	NOUN
admet-2756	146	10	of	of	ADP
admet-2756	146	11	calcium	calcium	NOUN
admet-2756	146	12	-	-	PUNCT
admet-2756	146	13	based	base	VERB
admet-2756	146	14	drug	drug	NOUN
admet-2756	146	15	delivery	delivery	NOUN
admet-2756	146	16	systems	system	NOUN
admet-2756	146	17	and	and	CCONJ
admet-2756	146	18	their	their	PRON
admet-2756	146	19	release	release	NOUN
admet-2756	146	20	profiles	profile	NOUN
admet-2756	146	21	.	.	PUNCT
admet-2756	147	1	as	as	ADP
admet-2756	147	2	evident	evident	ADJ
admet-2756	147	3	from	from	ADP
admet-2756	147	4	the	the	DET
admet-2756	147	5	data	datum	NOUN
admet-2756	147	6	,	,	PUNCT
admet-2756	147	7	bg	bg	PROPN
admet-2756	147	8	significantly	significantly	ADV
admet-2756	147	9	outperforms	outperform	VERB
admet-2756	147	10	cp	cp	INTJ
admet-2756	147	11	and	and	CCONJ
admet-2756	147	12	hap	hap	NOUN
admet-2756	147	13	in	in	ADP
admet-2756	147	14	providing	provide	VERB
admet-2756	147	15	a	a	DET
admet-2756	147	16	more	more	ADV
admet-2756	147	17	sustained	sustained	ADJ
admet-2756	147	18	release	release	NOUN
admet-2756	147	19	profile	profile	NOUN
admet-2756	147	20	.	.	PUNCT
admet-2756	148	1	table	table	NOUN
admet-2756	148	2	4	4	NUM
admet-2756	148	3	.	.	PUNCT
admet-2756	149	1	study	study	NOUN
admet-2756	149	2	of	of	ADP
admet-2756	149	3	release	release	NOUN
admet-2756	149	4	profile	profile	NOUN
admet-2756	149	5	of	of	ADP
admet-2756	149	6	bisphosphonated	bisphosphonate	VERB
admet-2756	149	7	ca	ca	NOUN
admet-2756	149	8	-	-	PUNCT
admet-2756	149	9	based	base	VERB
admet-2756	149	10	drug	drug	NOUN
admet-2756	149	11	delivery	delivery	NOUN
admet-2756	149	12	systems	system	NOUN
admet-2756	149	13	carrier	carrier	NOUN
admet-2756	149	14	composition	composition	NOUN
admet-2756	149	15	bisphosphonate	bisphosphonate	NOUN
admet-2756	149	16	name	name	NOUN
admet-2756	149	17	cumulative	cumulative	ADJ
admet-2756	149	18	drug	drug	NOUN
admet-2756	149	19	release	release	NOUN
admet-2756	149	20	profile	profile	NOUN
admet-2756	149	21	ref	ref	NOUN
admet-2756	149	22	.	.	PUNCT
admet-2756	150	1	hap	hap	PROPN
admet-2756	150	2	alendronate	alendronate	VERB
admet-2756	150	3	90	90	PROPN
admet-2756	150	4	%	%	NOUN
admet-2756	150	5	in	in	ADP
admet-2756	150	6	3	3	NUM
admet-2756	150	7	h	h	NOUN
admet-2756	150	8	(	(	PUNCT
admet-2756	150	9	ph	ph	VERB
admet-2756	150	10	not	not	PART
admet-2756	150	11	specified	specify	VERB
admet-2756	150	12	)	)	PUNCT
admet-2756	151	1	[	[	X
admet-2756	151	2	28	28	NUM
admet-2756	151	3	]	]	X
admet-2756	151	4	cp	cp	PUNCT
admet-2756	151	5	alendronate	alendronate	VERB
admet-2756	151	6	90	90	PROPN
admet-2756	151	7	%	%	NOUN
admet-2756	151	8	in	in	ADP
admet-2756	151	9	3	3	NUM
admet-2756	151	10	h	h	NOUN
admet-2756	151	11	(	(	PUNCT
admet-2756	151	12	ph	ph	NOUN
admet-2756	151	13	4.7	4.7	NUM
admet-2756	151	14	)	)	PUNCT
admet-2756	152	1	[	[	X
admet-2756	152	2	29	29	NUM
admet-2756	152	3	]	]	PUNCT
admet-2756	152	4	bg	bg	NOUN
admet-2756	152	5	alendronate	alendronate	NOUN
admet-2756	152	6	65	65	PROPN
admet-2756	152	7	%	%	NOUN
admet-2756	152	8	in	in	ADP
admet-2756	152	9	48	48	NUM
admet-2756	152	10	h	h	NOUN
admet-2756	152	11	(	(	PUNCT
admet-2756	152	12	ph	ph	NOUN
admet-2756	152	13	4.5	4.5	NUM
admet-2756	152	14	)	)	PUNCT
admet-2756	153	1	[	[	X
admet-2756	153	2	30	30	NUM
admet-2756	153	3	]	]	PUNCT
admet-2756	153	4	calcium	calcium	NOUN
admet-2756	153	5	ion	ion	NOUN
admet-2756	153	6	risedronate	risedronate	NOUN
admet-2756	153	7	100	100	X
admet-2756	153	8	%	%	NOUN
admet-2756	153	9	in	in	ADP
admet-2756	153	10	48	48	NUM
admet-2756	153	11	h	h	NOUN
admet-2756	153	12	(	(	PUNCT
admet-2756	153	13	ph	ph	PROPN
admet-2756	153	14	5.5	5.5	NUM
admet-2756	153	15	)	)	PUNCT
admet-2756	154	1	[	[	X
admet-2756	154	2	31	31	NUM
admet-2756	154	3	]	]	X
admet-2756	154	4	hap	hap	NOUN
admet-2756	154	5	medronate	medronate	VERB
admet-2756	154	6	100	100	INTJ
admet-2756	154	7	%	%	NOUN
admet-2756	154	8	in	in	ADP
admet-2756	154	9	48	48	NUM
admet-2756	154	10	h	h	NOUN
admet-2756	154	11	(	(	PUNCT
admet-2756	154	12	ph	ph	VERB
admet-2756	154	13	not	not	PART
admet-2756	154	14	specified	specify	VERB
admet-2756	154	15	)	)	PUNCT
admet-2756	155	1	[	[	X
admet-2756	155	2	32	32	NUM
admet-2756	155	3	]	]	PUNCT
admet-2756	155	4	cp	cp	PUNCT
admet-2756	155	5	medronate	medronate	VERB
admet-2756	155	6	100	100	ADJ
admet-2756	155	7	%	%	NOUN
admet-2756	155	8	in	in	ADP
admet-2756	155	9	48	48	NUM
admet-2756	155	10	h	h	NOUN
admet-2756	155	11	(	(	PUNCT
admet-2756	155	12	ph	ph	VERB
admet-2756	155	13	not	not	PART
admet-2756	155	14	specified	specify	VERB
admet-2756	155	15	)	)	PUNCT
admet-2756	156	1	[	[	X
admet-2756	156	2	32	32	NUM
admet-2756	156	3	]	]	PUNCT
admet-2756	156	4	bisphosphonated	bisphosphonate	VERB
admet-2756	156	5	carbon	carbon	NOUN
admet-2756	156	6	-	-	PUNCT
admet-2756	156	7	based	base	VERB
admet-2756	156	8	systems	system	NOUN
admet-2756	156	9	carbon	carbon	NOUN
admet-2756	156	10	-	-	PUNCT
admet-2756	156	11	based	base	VERB
admet-2756	156	12	systems	system	NOUN
admet-2756	156	13	refer	refer	VERB
admet-2756	156	14	to	to	ADP
admet-2756	156	15	inorganic	inorganic	ADJ
admet-2756	156	16	carbon	carbon	NOUN
admet-2756	156	17	-	-	PUNCT
admet-2756	156	18	based	base	VERB
admet-2756	156	19	structures	structure	NOUN
admet-2756	156	20	such	such	ADJ
admet-2756	156	21	as	as	ADP
admet-2756	156	22	graphene	graphene	ADJ
admet-2756	156	23	oxide	oxide	NOUN
admet-2756	156	24	and	and	CCONJ
admet-2756	156	25	carbon	carbon	NOUN
admet-2756	156	26	quantum	quantum	ADJ
admet-2756	156	27	dots	dot	NOUN
admet-2756	156	28	.	.	PUNCT
admet-2756	157	1	pham	pham	PROPN
admet-2756	157	2	et	et	PROPN
admet-2756	157	3	al	al	PROPN
admet-2756	157	4	.	.	PUNCT
admet-2756	158	1	[	[	X
admet-2756	158	2	33	33	NUM
admet-2756	158	3	]	]	PUNCT
admet-2756	158	4	used	use	VERB
admet-2756	158	5	aln	aln	PROPN
admet-2756	158	6	-	-	PUNCT
admet-2756	158	7	functionalized	functionalize	VERB
admet-2756	158	8	graphene	graphene	NOUN
admet-2756	158	9	oxide	oxide	NOUN
admet-2756	158	10	nanosheets	nanosheet	NOUN
admet-2756	158	11	(	(	PUNCT
admet-2756	158	12	gon	gon	PROPN
admet-2756	158	13	)	)	PUNCT
admet-2756	158	14	for	for	ADP
admet-2756	158	15	dox	dox	ADJ
admet-2756	158	16	delivery	delivery	NOUN
admet-2756	158	17	to	to	ADP
admet-2756	158	18	tumor	tumor	NOUN
admet-2756	158	19	-	-	PUNCT
admet-2756	158	20	bearing	bear	VERB
admet-2756	158	21	bone	bone	NOUN
admet-2756	158	22	(	(	PUNCT
admet-2756	158	23	dox@gon	dox@gon	PROPN
admet-2756	158	24	-	-	PUNCT
admet-2756	158	25	aln	aln	PROPN
admet-2756	158	26	)	)	PUNCT
admet-2756	158	27	.	.	PUNCT
admet-2756	159	1	the	the	DET
admet-2756	159	2	chemical	chemical	NOUN
admet-2756	159	3	structure	structure	NOUN
admet-2756	159	4	and	and	CCONJ
admet-2756	159	5	schematic	schematic	ADJ
admet-2756	159	6	illustration	illustration	NOUN
admet-2756	159	7	of	of	ADP
admet-2756	159	8	this	this	DET
admet-2756	159	9	system	system	NOUN
admet-2756	159	10	are	be	AUX
admet-2756	159	11	shown	show	VERB
admet-2756	159	12	in	in	ADP
admet-2756	159	13	figure	figure	NOUN
admet-2756	159	14	4	4	NUM
admet-2756	159	15	.	.	PUNCT
admet-2756	159	16	notably	notably	ADV
admet-2756	159	17	,	,	PUNCT
admet-2756	159	18	gon	gon	PROPN
admet-2756	159	19	-	-	PUNCT
admet-2756	159	20	aln	aln	PROPN
admet-2756	159	21	yielded	yield	VERB
admet-2756	159	22	an	an	DET
admet-2756	159	23	impressive	impressive	ADJ
admet-2756	159	24	dox	dox	NOUN
admet-2756	159	25	loading	loading	NOUN
admet-2756	159	26	capacity	capacity	NOUN
admet-2756	159	27	and	and	CCONJ
admet-2756	159	28	encapsulation	encapsulation	NOUN
admet-2756	159	29	efficiency	efficiency	NOUN
admet-2756	159	30	of	of	ADP
admet-2756	159	31	99.1	99.1	NUM
admet-2756	159	32	and	and	CCONJ
admet-2756	159	33	98.5	98.5	NUM
admet-2756	159	34	%	%	NOUN
admet-2756	159	35	,	,	PUNCT
admet-2756	159	36	respectively	respectively	ADV
admet-2756	159	37	.	.	PUNCT
admet-2756	160	1	in	in	ADP
admet-2756	160	2	a	a	DET
admet-2756	160	3	3d	3d	NUM
admet-2756	160	4	collagen	collagen	NOUN
admet-2756	160	5	gel	gel	NOUN
admet-2756	160	6	containing	contain	VERB
admet-2756	160	7	hap	hap	NOUN
admet-2756	160	8	and	and	CCONJ
admet-2756	160	9	cancerous	cancerous	ADJ
admet-2756	160	10	cells	cell	NOUN
admet-2756	160	11	,	,	PUNCT
admet-2756	160	12	alnfunctionalized	alnfunctionalize	VERB
admet-2756	160	13	nanosheets	nanosheet	NOUN
admet-2756	160	14	yielded	yield	VERB
admet-2756	160	15	noticeably	noticeably	ADV
admet-2756	160	16	lower	low	ADJ
admet-2756	160	17	cell	cell	NOUN
admet-2756	160	18	viability	viability	NOUN
admet-2756	160	19	(	(	PUNCT
admet-2756	160	20	less	less	ADJ
admet-2756	160	21	than	than	ADP
admet-2756	160	22	50	50	NUM
admet-2756	160	23	%	%	NOUN
admet-2756	160	24	)	)	PUNCT
admet-2756	160	25	compared	compare	VERB
admet-2756	160	26	to	to	ADP
admet-2756	160	27	naked	naked	ADJ
admet-2756	160	28	nanosheets	nanosheet	NOUN
admet-2756	160	29	,	,	PUNCT
admet-2756	160	30	which	which	PRON
admet-2756	160	31	signified	signify	VERB
admet-2756	160	32	the	the	DET
admet-2756	160	33	role	role	NOUN
admet-2756	160	34	of	of	ADP
admet-2756	160	35	aln	aln	PROPN
admet-2756	160	36	for	for	ADP
admet-2756	160	37	targeting	target	VERB
admet-2756	160	38	purposes	purpose	NOUN
admet-2756	160	39	.	.	PUNCT
admet-2756	161	1	in	in	ADP
admet-2756	161	2	vivo	vivo	ADJ
admet-2756	161	3	imaging	imaging	NOUN
admet-2756	161	4	revealed	reveal	VERB
admet-2756	161	5	preferential	preferential	ADJ
admet-2756	161	6	accumulation	accumulation	NOUN
admet-2756	161	7	of	of	ADP
admet-2756	161	8	dox@gon	dox@gon	PROPN
admet-2756	161	9	-	-	PUNCT
admet-2756	161	10	aln	aln	PROPN
admet-2756	161	11	in	in	ADP
admet-2756	161	12	tumor	tumor	NOUN
admet-2756	161	13	-	-	PUNCT
admet-2756	161	14	bearing	bear	VERB
admet-2756	161	15	bone	bone	NOUN
admet-2756	161	16	rather	rather	ADV
admet-2756	161	17	than	than	ADP
admet-2756	161	18	healthy	healthy	ADJ
admet-2756	161	19	bone	bone	NOUN
admet-2756	161	20	,	,	PUNCT
admet-2756	161	21	which	which	PRON
admet-2756	161	22	can	can	AUX
admet-2756	161	23	be	be	AUX
admet-2756	161	24	associated	associate	VERB
admet-2756	161	25	with	with	ADP
admet-2756	161	26	extreme	extreme	ADJ
admet-2756	161	27	hap	hap	PROPN
admet-2756	161	28	exposure	exposure	NOUN
admet-2756	161	29	in	in	ADP
admet-2756	161	30	cancerous	cancerous	ADJ
admet-2756	161	31	bone	bone	NOUN
admet-2756	161	32	tissue	tissue	NOUN
admet-2756	161	33	.	.	PUNCT
admet-2756	162	1	such	such	ADJ
admet-2756	162	2	exposure	exposure	NOUN
admet-2756	162	3	makes	make	VERB
admet-2756	162	4	the	the	DET
admet-2756	162	5	mineral	mineral	NOUN
admet-2756	162	6	matrix	matrix	NOUN
admet-2756	162	7	more	more	ADV
admet-2756	162	8	available	available	ADJ
admet-2756	162	9	to	to	ADP
admet-2756	162	10	bp	bp	PROPN
admet-2756	162	11	ligands	ligand	NOUN
admet-2756	162	12	for	for	ADP
admet-2756	162	13	binding	bind	VERB
admet-2756	162	14	[	[	X
admet-2756	162	15	34,35	34,35	NOUN
admet-2756	162	16	]	]	PUNCT
admet-2756	162	17	.	.	PUNCT
admet-2756	163	1	lee	lee	PROPN
admet-2756	163	2	et	et	PROPN
admet-2756	163	3	al	al	PROPN
admet-2756	163	4	.	.	PUNCT
admet-2756	164	1	[	[	X
admet-2756	164	2	36	36	NUM
admet-2756	164	3	]	]	PUNCT
admet-2756	164	4	developed	develop	VERB
admet-2756	164	5	polymeric	polymeric	ADJ
admet-2756	164	6	quantum	quantum	NOUN
admet-2756	164	7	dots	dot	NOUN
admet-2756	164	8	(	(	PUNCT
admet-2756	164	9	pqds	pqds	PROPN
admet-2756	164	10	)	)	PUNCT
admet-2756	164	11	by	by	ADP
admet-2756	164	12	coating	coat	VERB
admet-2756	164	13	the	the	DET
admet-2756	164	14	surface	surface	NOUN
admet-2756	164	15	of	of	ADP
admet-2756	164	16	fullerene	fullerene	NOUN
admet-2756	164	17	(	(	PUNCT
admet-2756	164	18	c60	c60	NOUN
admet-2756	164	19	)	)	PUNCT
admet-2756	164	20	dots	dot	NOUN
admet-2756	164	21	using	use	VERB
admet-2756	164	22	ha	ha	INTJ
admet-2756	164	23	.	.	PUNCT
admet-2756	165	1	the	the	DET
admet-2756	165	2	presence	presence	NOUN
admet-2756	165	3	of	of	ADP
admet-2756	165	4	a	a	DET
admet-2756	165	5	variety	variety	NOUN
admet-2756	165	6	of	of	ADP
admet-2756	165	7	functional	functional	ADJ
admet-2756	165	8	groups	group	NOUN
admet-2756	165	9	in	in	ADP
admet-2756	165	10	the	the	DET
admet-2756	165	11	ha	ha	INTJ
admet-2756	165	12	structure	structure	NOUN
admet-2756	165	13	,	,	PUNCT
admet-2756	165	14	coupled	couple	VERB
admet-2756	165	15	with	with	ADP
admet-2756	165	16	a	a	DET
admet-2756	165	17	large	large	ADJ
admet-2756	165	18	surface	surface	NOUN
admet-2756	165	19	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	PROPN
admet-2756	165	20	m.	m.	PROPN
admet-2756	165	21	eshaghi	eshaghi	PROPN
admet-2756	165	22	et	et	PROPN
admet-2756	165	23	al	al	PROPN
admet-2756	165	24	.	.	PROPN
admet-2756	165	25	admet	admet	PROPN
admet-2756	165	26	&	&	CCONJ
admet-2756	165	27	dmpk	dmpk	PROPN
admet-2756	165	28	13(3	13(3	NUM
admet-2756	165	29	)	)	PUNCT
admet-2756	165	30	(	(	PUNCT
admet-2756	165	31	2025	2025	NUM
admet-2756	165	32	)	)	PUNCT
admet-2756	165	33	2756	2756	NUM
admet-2756	165	34	8	8	NUM
admet-2756	165	35	area	area	NOUN
admet-2756	165	36	of	of	ADP
admet-2756	165	37	quantum	quantum	ADJ
admet-2756	165	38	dots	dot	NOUN
admet-2756	165	39	,	,	PUNCT
admet-2756	165	40	facilitated	facilitate	VERB
admet-2756	165	41	its	its	PRON
admet-2756	165	42	modification	modification	NOUN
admet-2756	165	43	with	with	ADP
admet-2756	165	44	multiple	multiple	ADJ
admet-2756	165	45	components	component	NOUN
admet-2756	165	46	,	,	PUNCT
admet-2756	165	47	including	include	VERB
admet-2756	165	48	aln	aln	PROPN
admet-2756	165	49	for	for	ADP
admet-2756	165	50	bone	bone	NOUN
admet-2756	165	51	targeting	targeting	NOUN
admet-2756	165	52	,	,	PUNCT
admet-2756	165	53	rgd	rgd	PROPN
admet-2756	165	54	for	for	ADP
admet-2756	165	55	integrin	integrin	NOUN
admet-2756	165	56	targeting	target	VERB
admet-2756	165	57	,	,	PUNCT
admet-2756	165	58	and	and	CCONJ
admet-2756	165	59	chlorin	chlorin	PROPN
admet-2756	165	60	e6	e6	PROPN
admet-2756	165	61	(	(	PUNCT
admet-2756	165	62	ce6	ce6	PROPN
admet-2756	165	63	)	)	PUNCT
admet-2756	165	64	for	for	ADP
admet-2756	165	65	photodynamic	photodynamic	ADJ
admet-2756	165	66	therapy	therapy	NOUN
admet-2756	165	67	of	of	ADP
admet-2756	165	68	bone	bone	NOUN
admet-2756	165	69	tumour	tumour	NOUN
admet-2756	165	70	.	.	PUNCT
admet-2756	166	1	the	the	DET
admet-2756	166	2	small	small	ADJ
admet-2756	166	3	size	size	NOUN
admet-2756	166	4	of	of	ADP
admet-2756	166	5	quantum	quantum	ADJ
admet-2756	166	6	dots	dot	NOUN
admet-2756	166	7	(	(	PUNCT
admet-2756	166	8	smaller	small	ADJ
admet-2756	166	9	than	than	ADP
admet-2756	166	10	10	10	NUM
admet-2756	166	11	nm	nm	NOUN
admet-2756	166	12	)	)	PUNCT
admet-2756	166	13	is	be	AUX
admet-2756	166	14	a	a	DET
admet-2756	166	15	major	major	ADJ
admet-2756	166	16	advantage	advantage	NOUN
admet-2756	166	17	and	and	CCONJ
admet-2756	166	18	inhibits	inhibit	VERB
admet-2756	166	19	steric	steric	ADJ
admet-2756	166	20	hindrance	hindrance	NOUN
admet-2756	166	21	for	for	ADP
admet-2756	166	22	the	the	DET
admet-2756	166	23	effective	effective	ADJ
admet-2756	166	24	interaction	interaction	NOUN
admet-2756	166	25	of	of	ADP
admet-2756	166	26	aln	aln	PROPN
admet-2756	166	27	and	and	CCONJ
admet-2756	166	28	rgd	rgd	X
admet-2756	166	29	with	with	ADP
admet-2756	166	30	their	their	PRON
admet-2756	166	31	receptors	receptor	NOUN
admet-2756	166	32	.	.	PUNCT
admet-2756	167	1	in	in	ADP
admet-2756	167	2	vivo	vivo	ADJ
admet-2756	167	3	biodistribution	biodistribution	NOUN
admet-2756	167	4	test	test	NOUN
admet-2756	167	5	using	use	VERB
admet-2756	167	6	single	single	ADJ
admet-2756	167	7	-	-	PUNCT
admet-2756	167	8	ligand	ligand	NOUN
admet-2756	167	9	formulations	formulation	NOUN
admet-2756	167	10	revealed	reveal	VERB
admet-2756	167	11	that	that	SCONJ
admet-2756	167	12	aln	aln	PROPN
admet-2756	167	13	is	be	AUX
admet-2756	167	14	more	more	ADV
admet-2756	167	15	effective	effective	ADJ
admet-2756	167	16	than	than	ADP
admet-2756	167	17	rgd	rgd	NOUN
admet-2756	167	18	in	in	ADP
admet-2756	167	19	delivering	deliver	VERB
admet-2756	167	20	pqds	pqds	NOUN
admet-2756	167	21	to	to	ADP
admet-2756	167	22	the	the	DET
admet-2756	167	23	site	site	NOUN
admet-2756	167	24	of	of	ADP
admet-2756	167	25	tumour	tumour	NOUN
admet-2756	167	26	-	-	PUNCT
admet-2756	167	27	bearing	bear	VERB
admet-2756	167	28	bone	bone	NOUN
admet-2756	167	29	.	.	PUNCT
admet-2756	168	1	therefore	therefore	ADV
admet-2756	168	2	,	,	PUNCT
admet-2756	168	3	bps	bps	NOUN
admet-2756	168	4	should	should	AUX
admet-2756	168	5	be	be	AUX
admet-2756	168	6	prioritized	prioritize	VERB
admet-2756	168	7	over	over	ADP
admet-2756	168	8	tumour	tumour	NOUN
admet-2756	168	9	-	-	PUNCT
admet-2756	168	10	specific	specific	ADJ
admet-2756	168	11	ligands	ligand	NOUN
admet-2756	168	12	like	like	ADP
admet-2756	168	13	rgd	rgd	X
admet-2756	168	14	for	for	ADP
admet-2756	168	15	designing	design	VERB
admet-2756	168	16	drug	drug	NOUN
admet-2756	168	17	delivery	delivery	NOUN
admet-2756	168	18	systems	system	NOUN
admet-2756	168	19	for	for	ADP
admet-2756	168	20	bone	bone	NOUN
admet-2756	168	21	tumours	tumour	NOUN
admet-2756	168	22	.	.	PUNCT
admet-2756	169	1	this	this	DET
admet-2756	169	2	research	research	NOUN
admet-2756	169	3	was	be	AUX
admet-2756	169	4	one	one	NUM
admet-2756	169	5	of	of	ADP
admet-2756	169	6	the	the	DET
admet-2756	169	7	few	few	ADJ
admet-2756	169	8	with	with	ADP
admet-2756	169	9	successful	successful	ADJ
admet-2756	169	10	results	result	NOUN
admet-2756	169	11	in	in	ADP
admet-2756	169	12	vivo	vivo	NOUN
admet-2756	169	13	and	and	CCONJ
admet-2756	169	14	managed	manage	VERB
admet-2756	169	15	to	to	PART
admet-2756	169	16	reduce	reduce	VERB
admet-2756	169	17	tumour	tumour	NOUN
admet-2756	169	18	volume	volume	NOUN
admet-2756	169	19	in	in	ADP
admet-2756	169	20	mice	mouse	NOUN
admet-2756	169	21	models	model	NOUN
admet-2756	169	22	.	.	PUNCT
admet-2756	170	1	figure	figure	VERB
admet-2756	170	2	4	4	NUM
admet-2756	170	3	.	.	PUNCT
admet-2756	171	1	(	(	PUNCT
admet-2756	171	2	a	a	X
admet-2756	171	3	)	)	PUNCT
admet-2756	171	4	chemical	chemical	NOUN
admet-2756	171	5	structure	structure	NOUN
admet-2756	171	6	of	of	ADP
admet-2756	171	7	gon	gon	PROPN
admet-2756	171	8	-	-	PUNCT
admet-2756	171	9	aln	aln	PROPN
admet-2756	171	10	,	,	PUNCT
admet-2756	171	11	(	(	PUNCT
admet-2756	171	12	b	b	NOUN
admet-2756	171	13	)	)	PUNCT
admet-2756	171	14	demonstration	demonstration	NOUN
admet-2756	171	15	of	of	ADP
admet-2756	171	16	gon	gon	PROPN
admet-2756	171	17	-	-	PUNCT
admet-2756	171	18	aln	aln	PROPN
admet-2756	171	19	affinity	affinity	NOUN
admet-2756	171	20	for	for	ADP
admet-2756	171	21	calcium	calcium	NOUN
admet-2756	171	22	ions	ion	NOUN
admet-2756	171	23	bisphosphonated	bisphosphonate	VERB
admet-2756	171	24	self	self	NOUN
admet-2756	171	25	-	-	PUNCT
admet-2756	171	26	assembling	assemble	VERB
admet-2756	171	27	systems	system	NOUN
admet-2756	171	28	the	the	DET
admet-2756	171	29	formation	formation	NOUN
admet-2756	171	30	of	of	ADP
admet-2756	171	31	self	self	NOUN
admet-2756	171	32	-	-	PUNCT
admet-2756	171	33	assembling	assemble	VERB
admet-2756	171	34	systems	system	NOUN
admet-2756	171	35	relies	rely	VERB
admet-2756	171	36	upon	upon	SCONJ
admet-2756	171	37	the	the	DET
admet-2756	171	38	amphiphilic	amphiphilic	ADJ
admet-2756	171	39	nature	nature	NOUN
admet-2756	171	40	of	of	ADP
admet-2756	171	41	the	the	DET
admet-2756	171	42	constituting	constitute	VERB
admet-2756	171	43	molecules	molecule	NOUN
admet-2756	171	44	or	or	CCONJ
admet-2756	171	45	macromolecules	macromolecule	NOUN
admet-2756	171	46	,	,	PUNCT
admet-2756	171	47	which	which	PRON
admet-2756	171	48	leads	lead	VERB
admet-2756	171	49	to	to	ADP
admet-2756	171	50	the	the	DET
admet-2756	171	51	formation	formation	NOUN
admet-2756	171	52	of	of	ADP
admet-2756	171	53	a	a	DET
admet-2756	171	54	core	core	ADJ
admet-2756	171	55	-	-	PUNCT
admet-2756	171	56	shell	shell	NOUN
admet-2756	171	57	structure	structure	NOUN
admet-2756	171	58	.	.	PUNCT
admet-2756	172	1	polymeric	polymeric	ADJ
admet-2756	172	2	micelles	micelle	NOUN
admet-2756	172	3	are	be	AUX
admet-2756	172	4	selfassembling	selfassemble	VERB
admet-2756	172	5	systems	system	NOUN
admet-2756	172	6	that	that	PRON
admet-2756	172	7	are	be	AUX
admet-2756	172	8	being	be	AUX
admet-2756	172	9	widely	widely	ADV
admet-2756	172	10	researched	research	VERB
admet-2756	172	11	for	for	ADP
admet-2756	172	12	drug	drug	NOUN
admet-2756	172	13	delivery	delivery	NOUN
admet-2756	172	14	applications	application	NOUN
admet-2756	172	15	.	.	PUNCT
admet-2756	173	1	in	in	ADP
admet-2756	173	2	the	the	DET
admet-2756	173	3	aqueous	aqueous	ADJ
admet-2756	173	4	medium	medium	NOUN
admet-2756	173	5	of	of	ADP
admet-2756	173	6	blood	blood	NOUN
admet-2756	173	7	plasma	plasma	NOUN
admet-2756	173	8	,	,	PUNCT
admet-2756	173	9	the	the	DET
admet-2756	173	10	hydrophobic	hydrophobic	NOUN
admet-2756	173	11	end	end	NOUN
admet-2756	173	12	of	of	ADP
admet-2756	173	13	the	the	DET
admet-2756	173	14	constituting	constitute	VERB
admet-2756	173	15	molecules	molecule	NOUN
admet-2756	173	16	forms	form	VERB
admet-2756	173	17	the	the	DET
admet-2756	173	18	core	core	NOUN
admet-2756	173	19	,	,	PUNCT
admet-2756	173	20	and	and	CCONJ
admet-2756	173	21	the	the	DET
admet-2756	173	22	hydrophilic	hydrophilic	ADJ
admet-2756	173	23	end	end	NOUN
admet-2756	173	24	creates	create	VERB
admet-2756	173	25	the	the	DET
admet-2756	173	26	shell	shell	NOUN
admet-2756	174	1	[	[	X
admet-2756	174	2	37,38	37,38	NOUN
admet-2756	174	3	]	]	PUNCT
admet-2756	174	4	.	.	PUNCT
admet-2756	175	1	another	another	DET
admet-2756	175	2	class	class	NOUN
admet-2756	175	3	of	of	ADP
admet-2756	175	4	self	self	NOUN
admet-2756	175	5	-	-	PUNCT
admet-2756	175	6	assembling	assemble	VERB
admet-2756	175	7	systems	system	NOUN
admet-2756	175	8	are	be	AUX
admet-2756	175	9	liposomes	liposome	NOUN
admet-2756	175	10	,	,	PUNCT
admet-2756	175	11	which	which	PRON
admet-2756	175	12	are	be	AUX
admet-2756	175	13	made	make	VERB
admet-2756	175	14	of	of	ADP
admet-2756	175	15	two	two	NUM
admet-2756	175	16	layers	layer	NOUN
admet-2756	175	17	of	of	ADP
admet-2756	175	18	phospholipids	phospholipid	NOUN
admet-2756	175	19	.	.	PUNCT
admet-2756	176	1	the	the	DET
admet-2756	176	2	hydrophobic	hydrophobic	NOUN
admet-2756	176	3	tail	tail	NOUN
admet-2756	176	4	and	and	CCONJ
admet-2756	176	5	hydrophilic	hydrophilic	ADJ
admet-2756	176	6	head	head	NOUN
admet-2756	176	7	of	of	ADP
admet-2756	176	8	phospholipids	phospholipid	NOUN
admet-2756	176	9	form	form	VERB
admet-2756	176	10	a	a	DET
admet-2756	176	11	hydrophilic	hydrophilic	ADJ
admet-2756	176	12	core	core	NOUN
admet-2756	176	13	,	,	PUNCT
admet-2756	176	14	a	a	DET
admet-2756	176	15	hydrophobic	hydrophobic	NOUN
admet-2756	176	16	two	two	NUM
admet-2756	176	17	-	-	PUNCT
admet-2756	176	18	layer	layer	NOUN
admet-2756	176	19	wall	wall	NOUN
admet-2756	176	20	,	,	PUNCT
admet-2756	176	21	and	and	CCONJ
admet-2756	176	22	a	a	DET
admet-2756	176	23	hydrophilic	hydrophilic	ADJ
admet-2756	176	24	shell	shell	NOUN
admet-2756	176	25	.	.	PUNCT
admet-2756	177	1	therefore	therefore	ADV
admet-2756	177	2	,	,	PUNCT
admet-2756	177	3	liposomes	liposome	NOUN
admet-2756	177	4	can	can	AUX
admet-2756	177	5	carry	carry	VERB
admet-2756	177	6	hydrophobic	hydrophobic	NOUN
admet-2756	177	7	and	and	CCONJ
admet-2756	177	8	hydrophilic	hydrophilic	ADJ
admet-2756	177	9	drugs	drug	NOUN
admet-2756	177	10	simultaneously	simultaneously	ADV
admet-2756	177	11	.	.	PUNCT
admet-2756	178	1	several	several	ADJ
admet-2756	178	2	nanodrug	nanodrug	NOUN
admet-2756	178	3	products	product	NOUN
admet-2756	178	4	for	for	ADP
admet-2756	178	5	cancer	cancer	NOUN
admet-2756	178	6	therapy	therapy	NOUN
admet-2756	178	7	based	base	VERB
admet-2756	178	8	on	on	ADP
admet-2756	178	9	liposomes	liposome	NOUN
admet-2756	178	10	have	have	AUX
admet-2756	178	11	received	receive	VERB
admet-2756	178	12	fda	fda	PROPN
admet-2756	178	13	approval	approval	NOUN
admet-2756	178	14	over	over	ADP
admet-2756	178	15	the	the	DET
admet-2756	178	16	recent	recent	ADJ
admet-2756	178	17	years	year	NOUN
admet-2756	178	18	[	[	X
admet-2756	178	19	39,40	39,40	NUM
admet-2756	178	20	]	]	PUNCT
admet-2756	178	21	.	.	PUNCT
admet-2756	179	1	ye	ye	INTJ
admet-2756	179	2	et	et	PROPN
admet-2756	179	3	al	al	PROPN
admet-2756	179	4	.	.	PUNCT
admet-2756	180	1	[	[	X
admet-2756	180	2	41	41	NUM
admet-2756	180	3	]	]	PUNCT
admet-2756	180	4	developed	develop	VERB
admet-2756	180	5	dox	dox	NOUN
admet-2756	180	6	,	,	PUNCT
admet-2756	180	7	peg	peg	NOUN
admet-2756	180	8	,	,	PUNCT
admet-2756	180	9	and	and	CCONJ
admet-2756	180	10	aln	aln	NOUN
admet-2756	180	11	micelles	micelle	NOUN
admet-2756	180	12	for	for	ADP
admet-2756	180	13	treating	treat	VERB
admet-2756	180	14	metastatic	metastatic	ADJ
admet-2756	180	15	bone	bone	NOUN
admet-2756	180	16	tumours	tumour	NOUN
admet-2756	180	17	.	.	PUNCT
admet-2756	181	1	dox	dox	NOUN
admet-2756	181	2	and	and	CCONJ
admet-2756	181	3	peg	peg	NOUN
admet-2756	181	4	were	be	AUX
admet-2756	181	5	linked	link	VERB
admet-2756	181	6	through	through	ADP
admet-2756	181	7	a	a	DET
admet-2756	181	8	hydrazone	hydrazone	NOUN
admet-2756	181	9	bond	bond	NOUN
admet-2756	181	10	to	to	PART
admet-2756	181	11	obtain	obtain	VERB
admet-2756	181	12	a	a	DET
admet-2756	181	13	ph	ph	ADJ
admet-2756	181	14	-	-	ADJ
admet-2756	181	15	sensitive	sensitive	ADJ
admet-2756	181	16	system	system	NOUN
admet-2756	181	17	.	.	PUNCT
admet-2756	182	1	as	as	SCONJ
admet-2756	182	2	anticipated	anticipate	VERB
admet-2756	182	3	,	,	PUNCT
admet-2756	182	4	aln	aln	NOUN
admet-2756	182	5	-	-	PUNCT
admet-2756	182	6	modified	modify	VERB
admet-2756	182	7	micelle	micelle	NOUN
admet-2756	182	8	demonstrated	demonstrate	VERB
admet-2756	182	9	higher	high	ADJ
admet-2756	182	10	binding	bind	VERB
admet-2756	182	11	affinity	affinity	NOUN
admet-2756	182	12	to	to	PART
admet-2756	182	13	hap	hap	VERB
admet-2756	182	14	in	in	ADP
admet-2756	182	15	vitro	vitro	X
admet-2756	182	16	compared	compare	VERB
admet-2756	182	17	with	with	ADP
admet-2756	182	18	naked	naked	ADJ
admet-2756	182	19	micelle	micelle	NOUN
admet-2756	182	20	.	.	PUNCT
admet-2756	183	1	according	accord	VERB
admet-2756	183	2	to	to	ADP
admet-2756	183	3	the	the	DET
admet-2756	183	4	in	in	ADP
admet-2756	183	5	vivo	vivo	ADJ
admet-2756	183	6	distribution	distribution	NOUN
admet-2756	183	7	test	test	NOUN
admet-2756	183	8	,	,	PUNCT
admet-2756	183	9	the	the	DET
admet-2756	183	10	concentration	concentration	NOUN
admet-2756	183	11	of	of	ADP
admet-2756	183	12	aln	aln	PROPN
admet-2756	183	13	-	-	PUNCT
admet-2756	183	14	modified	modify	VERB
admet-2756	183	15	micelle	micelle	NOUN
admet-2756	183	16	in	in	ADP
admet-2756	183	17	the	the	DET
admet-2756	183	18	liver	liver	NOUN
admet-2756	183	19	and	and	CCONJ
admet-2756	183	20	other	other	ADJ
admet-2756	183	21	major	major	ADJ
admet-2756	183	22	organs	organ	NOUN
admet-2756	183	23	was	be	AUX
admet-2756	183	24	much	much	ADV
admet-2756	183	25	less	less	ADJ
admet-2756	183	26	than	than	ADP
admet-2756	183	27	that	that	PRON
admet-2756	183	28	of	of	ADP
admet-2756	183	29	free	free	ADJ
admet-2756	183	30	dox	dox	NOUN
admet-2756	183	31	.	.	PUNCT
admet-2756	184	1	the	the	DET
admet-2756	184	2	highest	high	ADJ
admet-2756	184	3	concentration	concentration	NOUN
admet-2756	184	4	of	of	ADP
admet-2756	184	5	micelles	micelle	NOUN
admet-2756	184	6	was	be	AUX
admet-2756	184	7	observed	observe	VERB
admet-2756	184	8	in	in	ADP
admet-2756	184	9	bone	bone	NOUN
admet-2756	184	10	tissue	tissue	NOUN
admet-2756	184	11	.	.	PUNCT
admet-2756	185	1	zhu	zhu	PROPN
admet-2756	185	2	et	et	PROPN
admet-2756	185	3	al	al	PROPN
admet-2756	185	4	.	.	PUNCT
admet-2756	186	1	[	[	X
admet-2756	186	2	42	42	NUM
admet-2756	186	3	]	]	PUNCT
admet-2756	186	4	prepared	prepare	VERB
admet-2756	186	5	self	self	NOUN
admet-2756	186	6	-	-	PUNCT
admet-2756	186	7	assembling	assemble	VERB
admet-2756	186	8	nps	nps	PROPN
admet-2756	186	9	for	for	ADP
admet-2756	186	10	the	the	DET
admet-2756	186	11	treatment	treatment	NOUN
admet-2756	186	12	of	of	ADP
admet-2756	186	13	bone	bone	NOUN
admet-2756	186	14	metastasis	metastasis	NOUN
admet-2756	186	15	using	use	VERB
admet-2756	186	16	block	block	NOUN
admet-2756	186	17	copolymers	copolymer	NOUN
admet-2756	186	18	consisting	consist	VERB
admet-2756	186	19	of	of	ADP
admet-2756	186	20	peg	peg	NOUN
admet-2756	186	21	as	as	ADP
admet-2756	186	22	the	the	DET
admet-2756	186	23	hydrophilic	hydrophilic	ADJ
admet-2756	186	24	segment	segment	NOUN
admet-2756	186	25	and	and	CCONJ
admet-2756	186	26	poly(l	poly(l	NOUN
admet-2756	186	27	-	-	PUNCT
admet-2756	186	28	lysine	lysine	NOUN
admet-2756	186	29	)	)	PUNCT
admet-2756	186	30	(	(	PUNCT
admet-2756	186	31	pll	pll	PROPN
admet-2756	186	32	)	)	PUNCT
admet-2756	186	33	as	as	ADP
admet-2756	186	34	the	the	DET
admet-2756	186	35	hydrophobic	hydrophobic	NOUN
admet-2756	186	36	segment	segment	NOUN
admet-2756	186	37	.	.	PUNCT
admet-2756	187	1	while	while	SCONJ
admet-2756	187	2	btz	btz	PROPN
admet-2756	187	3	was	be	AUX
admet-2756	187	4	grafted	graft	VERB
admet-2756	187	5	on	on	ADP
admet-2756	187	6	the	the	DET
admet-2756	187	7	pll	pll	NOUN
admet-2756	187	8	chains	chain	NOUN
admet-2756	187	9	using	use	VERB
admet-2756	187	10	catechol	catechol	NOUN
admet-2756	187	11	as	as	ADP
admet-2756	187	12	a	a	DET
admet-2756	187	13	ph	ph	ADJ
admet-2756	187	14	-	-	ADJ
admet-2756	187	15	sensitive	sensitive	ADJ
admet-2756	187	16	linker	linker	NOUN
admet-2756	187	17	,	,	PUNCT
admet-2756	187	18	aln	aln	PROPN
admet-2756	187	19	was	be	AUX
admet-2756	187	20	conjugated	conjugate	VERB
admet-2756	187	21	to	to	ADP
admet-2756	187	22	the	the	DET
admet-2756	187	23	peg	peg	NOUN
admet-2756	187	24	chains	chain	NOUN
admet-2756	187	25	.	.	PUNCT
admet-2756	188	1	an	an	DET
admet-2756	188	2	in	in	ADP
admet-2756	188	3	vitro	vitro	X
admet-2756	188	4	hap	hap	X
admet-2756	188	5	binding	bind	VERB
admet-2756	188	6	assay	assay	NOUN
admet-2756	188	7	was	be	AUX
admet-2756	188	8	performed	perform	VERB
admet-2756	188	9	using	use	VERB
admet-2756	188	10	different	different	ADJ
admet-2756	188	11	concentrations	concentration	NOUN
admet-2756	188	12	of	of	ADP
admet-2756	188	13	aln	aln	PROPN
admet-2756	188	14	in	in	ADP
admet-2756	188	15	the	the	DET
admet-2756	188	16	micelle	micelle	NOUN
admet-2756	188	17	.	.	PUNCT
admet-2756	189	1	the	the	DET
admet-2756	189	2	binding	bind	VERB
admet-2756	189	3	positively	positively	ADV
admet-2756	189	4	correlated	correlate	VERB
admet-2756	189	5	with	with	ADP
admet-2756	189	6	the	the	DET
admet-2756	189	7	amount	amount	NOUN
admet-2756	189	8	of	of	ADP
admet-2756	189	9	aln	aln	NOUN
admet-2756	189	10	used	use	VERB
admet-2756	189	11	in	in	ADP
admet-2756	189	12	the	the	DET
admet-2756	189	13	formulation	formulation	NOUN
admet-2756	189	14	,	,	PUNCT
admet-2756	189	15	verifying	verify	VERB
admet-2756	189	16	the	the	DET
admet-2756	189	17	bp	bp	PROPN
admet-2756	189	18	's	's	PART
admet-2756	189	19	functionality	functionality	NOUN
admet-2756	189	20	.	.	PUNCT
admet-2756	190	1	these	these	DET
admet-2756	190	2	admet	admet	PROPN
admet-2756	190	3	&	&	CCONJ
admet-2756	190	4	dmpk	dmpk	PROPN
admet-2756	190	5	13(3	13(3	NUM
admet-2756	190	6	)	)	PUNCT
admet-2756	190	7	(	(	PUNCT
admet-2756	190	8	2025	2025	NUM
admet-2756	190	9	)	)	PUNCT
admet-2756	190	10	2756	2756	NUM
admet-2756	190	11	bisphosphonates	bisphosphonate	NOUN
admet-2756	190	12	for	for	ADP
admet-2756	190	13	bone	bone	NOUN
admet-2756	190	14	cancer	cancer	NOUN
admet-2756	190	15	therapy	therapy	NOUN
admet-2756	190	16	doi	doi	NOUN
admet-2756	190	17	:	:	PUNCT
admet-2756	190	18	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	190	19	9	9	NUM
admet-2756	190	20	results	result	NOUN
admet-2756	190	21	were	be	AUX
admet-2756	190	22	further	far	ADV
admet-2756	190	23	verified	verify	VERB
admet-2756	190	24	by	by	ADP
admet-2756	190	25	in	in	ADP
admet-2756	190	26	vivo	vivo	ADJ
admet-2756	190	27	experiments	experiment	NOUN
admet-2756	190	28	,	,	PUNCT
admet-2756	190	29	as	as	SCONJ
admet-2756	190	30	the	the	DET
admet-2756	190	31	concentration	concentration	NOUN
admet-2756	190	32	of	of	ADP
admet-2756	190	33	aln	aln	PROPN
admet-2756	190	34	-	-	PUNCT
admet-2756	190	35	modified	modify	VERB
admet-2756	190	36	micelle	micelle	NOUN
admet-2756	190	37	in	in	ADP
admet-2756	190	38	the	the	DET
admet-2756	190	39	tumour	tumour	NOUN
admet-2756	190	40	site	site	NOUN
admet-2756	190	41	was	be	AUX
admet-2756	190	42	considerably	considerably	ADV
admet-2756	190	43	higher	high	ADJ
admet-2756	190	44	than	than	ADP
admet-2756	190	45	that	that	PRON
admet-2756	190	46	of	of	ADP
admet-2756	190	47	naked	naked	ADJ
admet-2756	190	48	micelle	micelle	NOUN
admet-2756	190	49	.	.	PUNCT
admet-2756	191	1	he	he	PRON
admet-2756	191	2	et	et	PROPN
admet-2756	191	3	al	al	PROPN
admet-2756	191	4	.	.	PUNCT
admet-2756	192	1	[	[	X
admet-2756	192	2	43	43	NUM
admet-2756	192	3	]	]	X
admet-2756	192	4	prepared	prepare	VERB
admet-2756	192	5	cisplatin	cisplatin	NOUN
admet-2756	192	6	-	-	PUNCT
admet-2756	192	7	loaded	load	VERB
admet-2756	192	8	coordination	coordination	NOUN
admet-2756	192	9	polymer	polymer	NOUN
admet-2756	192	10	nps	nps	PROPN
admet-2756	192	11	for	for	ADP
admet-2756	192	12	treating	treat	VERB
admet-2756	192	13	bone	bone	NOUN
admet-2756	192	14	metastasis	metastasis	NOUN
admet-2756	192	15	of	of	ADP
admet-2756	192	16	breast	breast	NOUN
admet-2756	192	17	cancer	cancer	NOUN
admet-2756	192	18	.	.	PUNCT
admet-2756	193	1	the	the	DET
admet-2756	193	2	formulation	formulation	NOUN
admet-2756	193	3	of	of	ADP
admet-2756	193	4	the	the	DET
admet-2756	193	5	amphiphilic	amphiphilic	ADJ
admet-2756	193	6	constituent	constituent	NOUN
admet-2756	193	7	included	include	VERB
admet-2756	193	8	octadecyl	octadecyl	NOUN
admet-2756	193	9	succinic	succinic	ADJ
admet-2756	193	10	anhydride	anhydride	NOUN
admet-2756	193	11	(	(	PUNCT
admet-2756	193	12	osa	osa	ADJ
admet-2756	193	13	)	)	PUNCT
admet-2756	193	14	as	as	ADP
admet-2756	193	15	hydrophobic	hydrophobic	NOUN
admet-2756	193	16	and	and	CCONJ
admet-2756	193	17	peg	peg	NOUN
admet-2756	193	18	as	as	ADP
admet-2756	193	19	hydrophilic	hydrophilic	ADJ
admet-2756	193	20	segment	segment	NOUN
admet-2756	193	21	(	(	PUNCT
admet-2756	193	22	osa	osa	ADJ
admet-2756	193	23	-	-	NOUN
admet-2756	193	24	peg	peg	NOUN
admet-2756	193	25	)	)	PUNCT
admet-2756	193	26	.	.	PUNCT
admet-2756	194	1	the	the	DET
admet-2756	194	2	nps	nps	PROPN
admet-2756	194	3	were	be	AUX
admet-2756	194	4	functionalized	functionalize	VERB
admet-2756	194	5	with	with	ADP
admet-2756	194	6	aln	aln	PROPN
admet-2756	194	7	(	(	PUNCT
admet-2756	194	8	osa	osa	PROPN
admet-2756	194	9	-	-	PUNCT
admet-2756	194	10	pegaln	pegaln	NOUN
admet-2756	194	11	)	)	PUNCT
admet-2756	194	12	.	.	PUNCT
admet-2756	195	1	in	in	ADP
admet-2756	195	2	vitro	vitro	X
admet-2756	195	3	hap	hap	X
admet-2756	195	4	binding	bind	VERB
admet-2756	195	5	assay	assay	PROPN
admet-2756	195	6	confirmed	confirm	VERB
admet-2756	195	7	the	the	DET
admet-2756	195	8	high	high	ADJ
admet-2756	195	9	affinity	affinity	NOUN
admet-2756	195	10	of	of	ADP
admet-2756	195	11	osa	osa	ADJ
admet-2756	195	12	-	-	PUNCT
admet-2756	195	13	peg	peg	NOUN
admet-2756	195	14	-	-	PUNCT
admet-2756	195	15	aln	aln	NOUN
admet-2756	195	16	for	for	ADP
admet-2756	195	17	hap	hap	NOUN
admet-2756	195	18	.	.	PUNCT
admet-2756	196	1	in	in	ADP
admet-2756	196	2	vivo	vivo	ADJ
admet-2756	196	3	experiments	experiment	NOUN
admet-2756	196	4	indicated	indicate	VERB
admet-2756	196	5	that	that	SCONJ
admet-2756	196	6	osa	osa	PROPN
admet-2756	196	7	-	-	PUNCT
admet-2756	196	8	peg	peg	NOUN
admet-2756	196	9	-	-	PUNCT
admet-2756	196	10	aln	aln	NOUN
admet-2756	196	11	accumulated	accumulate	VERB
admet-2756	196	12	in	in	ADP
admet-2756	196	13	the	the	DET
admet-2756	196	14	tumour	tumour	NOUN
admet-2756	196	15	site	site	NOUN
admet-2756	196	16	rather	rather	ADV
admet-2756	196	17	than	than	ADP
admet-2756	196	18	in	in	ADP
admet-2756	196	19	other	other	ADJ
admet-2756	196	20	organs	organ	NOUN
admet-2756	196	21	.	.	PUNCT
admet-2756	197	1	also	also	ADV
admet-2756	197	2	,	,	PUNCT
admet-2756	197	3	the	the	DET
admet-2756	197	4	accumulation	accumulation	NOUN
admet-2756	197	5	level	level	NOUN
admet-2756	197	6	was	be	AUX
admet-2756	197	7	much	much	ADV
admet-2756	197	8	higher	high	ADJ
admet-2756	197	9	than	than	ADP
admet-2756	197	10	that	that	PRON
admet-2756	197	11	of	of	ADP
admet-2756	197	12	naked	naked	PROPN
admet-2756	197	13	nps	nps	PROPN
admet-2756	197	14	.	.	PUNCT
admet-2756	198	1	feng	feng	PROPN
admet-2756	198	2	et	et	PROPN
admet-2756	198	3	al	al	PROPN
admet-2756	198	4	.	.	PUNCT
admet-2756	199	1	[	[	X
admet-2756	199	2	44	44	NUM
admet-2756	199	3	]	]	PUNCT
admet-2756	199	4	encapsulated	encapsulate	VERB
admet-2756	199	5	dox	dox	NOUN
admet-2756	199	6	in	in	ADP
admet-2756	199	7	liposomes	liposome	NOUN
admet-2756	199	8	,	,	PUNCT
admet-2756	199	9	which	which	PRON
admet-2756	199	10	were	be	AUX
admet-2756	199	11	functionalized	functionalize	VERB
admet-2756	199	12	with	with	ADP
admet-2756	199	13	aln	aln	PROPN
admet-2756	199	14	-	-	PUNCT
admet-2756	199	15	ha	ha	PROPN
admet-2756	199	16	ligand	ligand	NOUN
admet-2756	199	17	via	via	ADP
admet-2756	199	18	a	a	DET
admet-2756	199	19	disulfide	disulfide	NOUN
admet-2756	199	20	linker	linker	NOUN
admet-2756	199	21	.	.	PUNCT
admet-2756	200	1	this	this	DET
admet-2756	200	2	linker	linker	NOUN
admet-2756	200	3	would	would	AUX
admet-2756	200	4	,	,	PUNCT
admet-2756	200	5	in	in	ADP
admet-2756	200	6	turn	turn	NOUN
admet-2756	200	7	,	,	PUNCT
admet-2756	200	8	lead	lead	VERB
admet-2756	200	9	the	the	DET
admet-2756	200	10	liposomes	liposome	NOUN
admet-2756	200	11	to	to	ADP
admet-2756	200	12	bone	bone	NOUN
admet-2756	200	13	mineral	mineral	NOUN
admet-2756	200	14	matrix	matrix	NOUN
admet-2756	200	15	and	and	CCONJ
admet-2756	200	16	tumour	tumour	NOUN
admet-2756	200	17	cells	cell	NOUN
admet-2756	200	18	,	,	PUNCT
admet-2756	200	19	followed	follow	VERB
admet-2756	200	20	by	by	ADP
admet-2756	200	21	intracellular	intracellular	ADJ
admet-2756	200	22	redox	redox	NOUN
admet-2756	200	23	-	-	PUNCT
admet-2756	200	24	sensitive	sensitive	ADJ
admet-2756	200	25	release	release	NOUN
admet-2756	200	26	of	of	ADP
admet-2756	200	27	dox	dox	NOUN
admet-2756	200	28	.	.	PUNCT
admet-2756	201	1	the	the	DET
admet-2756	201	2	body	body	NOUN
admet-2756	201	3	weight	weight	NOUN
admet-2756	201	4	of	of	ADP
admet-2756	201	5	mice	mouse	NOUN
admet-2756	201	6	models	model	NOUN
admet-2756	201	7	treated	treat	VERB
admet-2756	201	8	with	with	ADP
admet-2756	201	9	the	the	DET
admet-2756	201	10	final	final	ADJ
admet-2756	201	11	liposome	liposome	NOUN
admet-2756	201	12	remained	remain	VERB
admet-2756	201	13	perfectly	perfectly	ADV
admet-2756	201	14	stable	stable	ADJ
admet-2756	201	15	,	,	PUNCT
admet-2756	201	16	demonstrating	demonstrate	VERB
admet-2756	201	17	minimal	minimal	ADJ
admet-2756	201	18	systemic	systemic	ADJ
admet-2756	201	19	side	side	NOUN
admet-2756	201	20	effects	effect	NOUN
admet-2756	201	21	resulting	result	VERB
admet-2756	201	22	from	from	ADP
admet-2756	201	23	alnmediated	alnmediate	VERB
admet-2756	201	24	targeting	targeting	NOUN
admet-2756	201	25	.	.	PUNCT
admet-2756	202	1	aln	aln	PROPN
admet-2756	202	2	-	-	PUNCT
admet-2756	202	3	containing	contain	VERB
admet-2756	202	4	liposomes	liposome	NOUN
admet-2756	202	5	exhibited	exhibit	VERB
admet-2756	202	6	higher	high	ADJ
admet-2756	202	7	accumulation	accumulation	NOUN
admet-2756	202	8	in	in	ADP
admet-2756	202	9	tumour	tumour	NOUN
admet-2756	202	10	sites	site	NOUN
admet-2756	202	11	in	in	ADP
admet-2756	202	12	vivo	vivo	NOUN
admet-2756	202	13	compared	compare	VERB
admet-2756	202	14	with	with	ADP
admet-2756	202	15	naked	naked	ADJ
admet-2756	202	16	liposomes	liposome	NOUN
admet-2756	202	17	.	.	PUNCT
admet-2756	203	1	xi	xi	X
admet-2756	203	2	et	et	PROPN
admet-2756	203	3	al	al	PROPN
admet-2756	203	4	.	.	PUNCT
admet-2756	204	1	[	[	X
admet-2756	204	2	45	45	NUM
admet-2756	204	3	]	]	PUNCT
admet-2756	204	4	functionalized	functionalized	ADJ
admet-2756	204	5	ha	ha	INTJ
admet-2756	204	6	-	-	ADJ
admet-2756	204	7	stearic	stearic	ADJ
admet-2756	204	8	acid	acid	NOUN
admet-2756	204	9	micelles	micelle	NOUN
admet-2756	204	10	with	with	ADP
admet-2756	204	11	aln	aln	PROPN
admet-2756	204	12	for	for	ADP
admet-2756	204	13	osteosarcoma	osteosarcoma	ADJ
admet-2756	204	14	therapy	therapy	NOUN
admet-2756	204	15	using	use	VERB
admet-2756	204	16	curcumin	curcumin	NOUN
admet-2756	204	17	(	(	PUNCT
admet-2756	204	18	cur	cur	PROPN
admet-2756	204	19	)	)	PUNCT
admet-2756	204	20	.	.	PUNCT
admet-2756	205	1	as	as	SCONJ
admet-2756	205	2	expected	expect	VERB
admet-2756	205	3	,	,	PUNCT
admet-2756	205	4	the	the	DET
admet-2756	205	5	amount	amount	NOUN
admet-2756	205	6	of	of	ADP
admet-2756	205	7	aln	aln	NOUN
admet-2756	205	8	-	-	PUNCT
admet-2756	205	9	functionalized	functionalize	VERB
admet-2756	205	10	micelle	micelle	NOUN
admet-2756	205	11	bound	bind	VERB
admet-2756	205	12	to	to	ADP
admet-2756	205	13	hap	hap	PROPN
admet-2756	205	14	was	be	AUX
admet-2756	205	15	much	much	ADV
admet-2756	205	16	higher	high	ADJ
admet-2756	205	17	than	than	ADP
admet-2756	205	18	that	that	PRON
admet-2756	205	19	of	of	ADP
admet-2756	205	20	a	a	DET
admet-2756	205	21	naked	naked	ADJ
admet-2756	205	22	micelle	micelle	NOUN
admet-2756	205	23	.	.	PUNCT
admet-2756	206	1	importantly	importantly	ADV
admet-2756	206	2	,	,	PUNCT
admet-2756	206	3	the	the	DET
admet-2756	206	4	prepared	prepared	ADJ
admet-2756	206	5	micelle	micelle	NOUN
admet-2756	206	6	had	have	VERB
admet-2756	206	7	a	a	DET
admet-2756	206	8	very	very	ADV
admet-2756	206	9	low	low	ADJ
admet-2756	206	10	critical	critical	ADJ
admet-2756	206	11	micelle	micelle	NOUN
admet-2756	206	12	concentration	concentration	NOUN
admet-2756	206	13	(	(	PUNCT
admet-2756	206	14	cmc	cmc	PROPN
admet-2756	206	15	)	)	PUNCT
admet-2756	206	16	,	,	PUNCT
admet-2756	206	17	which	which	PRON
admet-2756	206	18	assured	assure	VERB
admet-2756	206	19	increased	increase	VERB
admet-2756	206	20	in	in	ADP
admet-2756	206	21	vivo	vivo	ADJ
admet-2756	206	22	stability	stability	NOUN
admet-2756	206	23	.	.	PUNCT
admet-2756	207	1	this	this	DET
admet-2756	207	2	achievement	achievement	NOUN
admet-2756	207	3	is	be	AUX
admet-2756	207	4	crucial	crucial	ADJ
admet-2756	207	5	for	for	ADP
admet-2756	207	6	micelles	micelle	NOUN
admet-2756	207	7	since	since	SCONJ
admet-2756	207	8	high	high	ADJ
admet-2756	207	9	cmc	cmc	NOUN
admet-2756	207	10	values	value	NOUN
admet-2756	207	11	could	could	AUX
admet-2756	207	12	cause	cause	VERB
admet-2756	207	13	the	the	DET
admet-2756	207	14	collapse	collapse	NOUN
admet-2756	207	15	of	of	ADP
admet-2756	207	16	the	the	DET
admet-2756	207	17	micelle	micelle	NOUN
admet-2756	207	18	structure	structure	NOUN
admet-2756	207	19	after	after	ADP
admet-2756	207	20	intravenous	intravenous	ADJ
admet-2756	207	21	injection	injection	NOUN
admet-2756	207	22	.	.	PUNCT
admet-2756	208	1	this	this	DET
admet-2756	208	2	low	low	ADJ
admet-2756	208	3	cmc	cmc	NOUN
admet-2756	208	4	value	value	NOUN
admet-2756	208	5	can	can	AUX
admet-2756	208	6	be	be	AUX
admet-2756	208	7	associated	associate	VERB
admet-2756	208	8	with	with	ADP
admet-2756	208	9	the	the	DET
admet-2756	208	10	proper	proper	ADJ
admet-2756	208	11	choice	choice	NOUN
admet-2756	208	12	of	of	ADP
admet-2756	208	13	the	the	DET
admet-2756	208	14	hydrophobic	hydrophobic	NOUN
admet-2756	208	15	segment	segment	NOUN
admet-2756	208	16	with	with	ADP
admet-2756	208	17	a	a	DET
admet-2756	208	18	partition	partition	NOUN
admet-2756	208	19	coefficient	coefficient	NOUN
admet-2756	208	20	that	that	PRON
admet-2756	208	21	is	be	AUX
admet-2756	208	22	large	large	ADJ
admet-2756	208	23	enough	enough	ADV
admet-2756	208	24	.	.	PUNCT
admet-2756	209	1	wu	wu	PROPN
admet-2756	209	2	et	et	PROPN
admet-2756	209	3	al	al	PROPN
admet-2756	209	4	.	.	PUNCT
admet-2756	210	1	[	[	X
admet-2756	210	2	46	46	NUM
admet-2756	210	3	]	]	X
admet-2756	210	4	modified	modify	VERB
admet-2756	210	5	dox	dox	NOUN
admet-2756	210	6	-	-	PUNCT
admet-2756	210	7	loaded	load	VERB
admet-2756	210	8	liposomes	liposome	NOUN
admet-2756	210	9	with	with	ADP
admet-2756	210	10	aln	aln	PROPN
admet-2756	210	11	and	and	CCONJ
admet-2756	210	12	heparin	heparin	NOUN
admet-2756	210	13	for	for	ADP
admet-2756	210	14	the	the	DET
admet-2756	210	15	treatment	treatment	NOUN
admet-2756	210	16	of	of	ADP
admet-2756	210	17	osteosarcoma	osteosarcoma	NOUN
admet-2756	210	18	and	and	CCONJ
admet-2756	210	19	bone	bone	NOUN
admet-2756	210	20	metastasis	metastasis	NOUN
admet-2756	210	21	of	of	ADP
admet-2756	210	22	breast	breast	NOUN
admet-2756	210	23	cancer	cancer	NOUN
admet-2756	210	24	.	.	PUNCT
admet-2756	211	1	heparin	heparin	NOUN
admet-2756	211	2	has	have	AUX
admet-2756	211	3	been	be	AUX
admet-2756	211	4	reported	report	VERB
admet-2756	211	5	to	to	PART
admet-2756	211	6	increase	increase	VERB
admet-2756	211	7	the	the	DET
admet-2756	211	8	blood	blood	NOUN
admet-2756	211	9	circulation	circulation	NOUN
admet-2756	211	10	time	time	NOUN
admet-2756	211	11	of	of	ADP
admet-2756	211	12	liposomes	liposome	NOUN
admet-2756	211	13	in	in	ADP
admet-2756	211	14	addition	addition	NOUN
admet-2756	211	15	to	to	ADP
admet-2756	211	16	possessing	possess	VERB
admet-2756	211	17	anti	anti	ADJ
admet-2756	211	18	-	-	ADJ
admet-2756	211	19	metastasis	metastasis	ADJ
admet-2756	211	20	properties	property	NOUN
admet-2756	211	21	.	.	PUNCT
admet-2756	212	1	nps	nps	PROPN
admet-2756	212	2	were	be	AUX
admet-2756	212	3	prepared	prepare	VERB
admet-2756	212	4	with	with	ADP
admet-2756	212	5	two	two	NUM
admet-2756	212	6	surface	surface	NOUN
admet-2756	212	7	densities	density	NOUN
admet-2756	212	8	of	of	ADP
admet-2756	212	9	aln	aln	PROPN
admet-2756	212	10	.	.	PUNCT
admet-2756	213	1	interestingly	interestingly	ADV
admet-2756	213	2	,	,	PUNCT
admet-2756	213	3	nps	nps	PROPN
admet-2756	213	4	with	with	ADP
admet-2756	213	5	smaller	small	ADJ
admet-2756	213	6	surface	surface	NOUN
admet-2756	213	7	density	density	NOUN
admet-2756	213	8	accumulated	accumulate	VERB
admet-2756	213	9	more	more	ADV
admet-2756	213	10	effectively	effectively	ADV
admet-2756	213	11	in	in	ADP
admet-2756	213	12	tumours	tumour	NOUN
admet-2756	213	13	in	in	ADP
admet-2756	213	14	vivo	vivo	NOUN
admet-2756	213	15	.	.	PUNCT
admet-2756	214	1	this	this	PRON
admet-2756	214	2	could	could	AUX
admet-2756	214	3	show	show	VERB
admet-2756	214	4	that	that	SCONJ
admet-2756	214	5	an	an	DET
admet-2756	214	6	optimized	optimize	VERB
admet-2756	214	7	concentration	concentration	NOUN
admet-2756	214	8	of	of	ADP
admet-2756	214	9	bps	bps	NOUN
admet-2756	214	10	needs	need	VERB
admet-2756	214	11	to	to	PART
admet-2756	214	12	be	be	AUX
admet-2756	214	13	determined	determine	VERB
admet-2756	214	14	for	for	ADP
admet-2756	214	15	the	the	DET
admet-2756	214	16	synthesis	synthesis	NOUN
admet-2756	214	17	procedure	procedure	NOUN
admet-2756	214	18	to	to	PART
admet-2756	214	19	obtain	obtain	VERB
admet-2756	214	20	maximized	maximized	ADJ
admet-2756	214	21	bone	bone	NOUN
admet-2756	214	22	targeting	target	VERB
admet-2756	214	23	efficiency	efficiency	NOUN
admet-2756	214	24	.	.	PUNCT
admet-2756	215	1	in	in	ADP
admet-2756	215	2	table	table	NOUN
admet-2756	215	3	5	5	NUM
admet-2756	215	4	,	,	PUNCT
admet-2756	215	5	we	we	PRON
admet-2756	215	6	have	have	AUX
admet-2756	215	7	compiled	compile	VERB
admet-2756	215	8	reports	report	NOUN
admet-2756	215	9	that	that	PRON
admet-2756	215	10	conducted	conduct	VERB
admet-2756	215	11	in	in	ADP
admet-2756	215	12	vitro	vitro	X
admet-2756	215	13	hap	hap	X
admet-2756	215	14	binding	bind	VERB
admet-2756	215	15	assays	assay	NOUN
admet-2756	215	16	to	to	PART
admet-2756	215	17	establish	establish	VERB
admet-2756	215	18	a	a	DET
admet-2756	215	19	correlation	correlation	NOUN
admet-2756	215	20	between	between	ADP
admet-2756	215	21	nanoparticle	nanoparticle	NOUN
admet-2756	215	22	size	size	NOUN
admet-2756	215	23	and	and	CCONJ
admet-2756	215	24	the	the	DET
admet-2756	215	25	targeting	target	VERB
admet-2756	215	26	efficiency	efficiency	NOUN
admet-2756	215	27	of	of	ADP
admet-2756	215	28	bps	bps	NOUN
admet-2756	215	29	.	.	PUNCT
admet-2756	216	1	it	it	PRON
admet-2756	216	2	was	be	AUX
admet-2756	216	3	concluded	conclude	VERB
admet-2756	216	4	that	that	SCONJ
admet-2756	216	5	bp	bp	NOUN
admet-2756	216	6	-	-	PUNCT
admet-2756	216	7	functionalized	functionalize	VERB
admet-2756	216	8	nps	nps	PROPN
admet-2756	216	9	with	with	ADP
admet-2756	216	10	hydrodynamic	hydrodynamic	ADJ
admet-2756	216	11	diameters	diameter	NOUN
admet-2756	216	12	above	above	ADP
admet-2756	216	13	100	100	NUM
admet-2756	216	14	nm	nm	NOUN
admet-2756	216	15	can	can	AUX
admet-2756	216	16	bind	bind	VERB
admet-2756	216	17	to	to	ADP
admet-2756	216	18	hap	hap	PROPN
admet-2756	216	19	more	more	ADV
admet-2756	216	20	effectively	effectively	ADV
admet-2756	216	21	than	than	ADP
admet-2756	216	22	those	those	PRON
admet-2756	216	23	with	with	ADP
admet-2756	216	24	sizes	size	NOUN
admet-2756	216	25	below	below	ADP
admet-2756	216	26	this	this	DET
admet-2756	216	27	value	value	NOUN
admet-2756	216	28	.	.	PUNCT
admet-2756	217	1	it	it	PRON
admet-2756	217	2	can	can	AUX
admet-2756	217	3	be	be	AUX
admet-2756	217	4	interpreted	interpret	VERB
admet-2756	217	5	that	that	SCONJ
admet-2756	217	6	larger	large	ADJ
admet-2756	217	7	nps	nps	PROPN
admet-2756	217	8	allow	allow	VERB
admet-2756	217	9	more	more	ADV
admet-2756	217	10	effective	effective	ADJ
admet-2756	217	11	interaction	interaction	NOUN
admet-2756	217	12	between	between	ADP
admet-2756	217	13	bp	bp	PROPN
admet-2756	217	14	ligands	ligand	NOUN
admet-2756	217	15	and	and	CCONJ
admet-2756	217	16	hap	hap	ADJ
admet-2756	217	17	crystals	crystal	NOUN
admet-2756	217	18	.	.	PUNCT
admet-2756	218	1	moreover	moreover	ADV
admet-2756	218	2	,	,	PUNCT
admet-2756	218	3	it	it	PRON
admet-2756	218	4	seems	seem	VERB
admet-2756	218	5	that	that	SCONJ
admet-2756	218	6	polymeric	polymeric	ADJ
admet-2756	218	7	micelles	micelle	NOUN
admet-2756	218	8	can	can	AUX
admet-2756	218	9	bind	bind	VERB
admet-2756	218	10	to	to	ADP
admet-2756	218	11	hap	hap	PROPN
admet-2756	218	12	more	more	ADV
admet-2756	218	13	efficiently	efficiently	ADV
admet-2756	218	14	than	than	ADP
admet-2756	218	15	lipid	lipid	NOUN
admet-2756	218	16	-	-	PUNCT
admet-2756	218	17	based	base	VERB
admet-2756	218	18	nps	nps	PROPN
admet-2756	218	19	.	.	PROPN
admet-2756	218	20	table	table	PROPN
admet-2756	218	21	5	5	NUM
admet-2756	218	22	.	.	PUNCT
admet-2756	218	23	hydrodynamic	hydrodynamic	ADJ
admet-2756	218	24	diameter	diameter	NOUN
admet-2756	218	25	and	and	CCONJ
admet-2756	218	26	hap	hap	ADJ
admet-2756	218	27	binding	bind	VERB
admet-2756	218	28	efficiency	efficiency	NOUN
admet-2756	218	29	of	of	ADP
admet-2756	218	30	self	self	NOUN
admet-2756	218	31	-	-	PUNCT
admet-2756	218	32	assembling	assemble	VERB
admet-2756	218	33	nps	nps	PROPN
admet-2756	218	34	(	(	PUNCT
admet-2756	218	35	bisphosphonate	bisphosphonate	NOUN
admet-2756	218	36	name	name	NOUN
admet-2756	218	37	alendronate	alendronate	NOUN
admet-2756	218	38	)	)	PUNCT
admet-2756	218	39	carrier	carrier	NOUN
admet-2756	218	40	type	type	NOUN
admet-2756	218	41	carrier	carrier	NOUN
admet-2756	218	42	composition	composition	NOUN
admet-2756	218	43	hydrodynamic	hydrodynamic	ADJ
admet-2756	218	44	diameter	diameter	NOUN
admet-2756	218	45	,	,	PUNCT
admet-2756	218	46	nm	nm	VERB
admet-2756	218	47	in	in	ADP
admet-2756	218	48	vitro	vitro	X
admet-2756	218	49	hap	hap	X
admet-2756	218	50	binding	bind	VERB
admet-2756	218	51	efficiency	efficiency	NOUN
admet-2756	218	52	,	,	PUNCT
admet-2756	218	53	%	%	INTJ
admet-2756	218	54	ref	ref	NOUN
admet-2756	218	55	.	.	PUNCT
admet-2756	219	1	lipid	lipid	NOUN
admet-2756	219	2	-	-	PUNCT
admet-2756	219	3	based	base	VERB
admet-2756	219	4	np	np	NOUN
admet-2756	219	5	dopa	dopa	NOUN
admet-2756	219	6	,	,	PUNCT
admet-2756	219	7	dopc	dopc	NOUN
admet-2756	219	8	,	,	PUNCT
admet-2756	219	9	osa	osa	X
admet-2756	219	10	,	,	PUNCT
admet-2756	219	11	peg	peg	NOUN
admet-2756	219	12	65	65	PROPN
admet-2756	219	13	40	40	PROPN
admet-2756	219	14	in	in	ADP
admet-2756	219	15	1	1	NUM
admet-2756	219	16	h	h	NOUN
admet-2756	220	1	[	[	X
admet-2756	220	2	43	43	NUM
admet-2756	220	3	]	]	PUNCT
admet-2756	220	4	dopa	dopa	NOUN
admet-2756	220	5	,	,	PUNCT
admet-2756	220	6	dopc	dopc	NOUN
admet-2756	220	7	,	,	PUNCT
admet-2756	220	8	osa	osa	PROPN
admet-2756	220	9	,	,	PUNCT
admet-2756	220	10	cholesterol	cholesterol	NOUN
admet-2756	220	11	,	,	PUNCT
admet-2756	220	12	peg	peg	NOUN
admet-2756	220	13	61	61	PROPN
admet-2756	220	14	20	20	PROPN
admet-2756	220	15	in	in	ADP
admet-2756	220	16	1	1	NUM
admet-2756	220	17	h	h	NOUN
admet-2756	221	1	[	[	X
admet-2756	221	2	47	47	NUM
admet-2756	221	3	]	]	PUNCT
admet-2756	221	4	dopa	dopa	NOUN
admet-2756	221	5	,	,	PUNCT
admet-2756	221	6	dopc	dopc	NOUN
admet-2756	221	7	,	,	PUNCT
admet-2756	221	8	osa	osa	PROPN
admet-2756	221	9	,	,	PUNCT
admet-2756	221	10	cholesterol	cholesterol	NOUN
admet-2756	221	11	,	,	PUNCT
admet-2756	221	12	peg	peg	NOUN
admet-2756	221	13	65	65	PROPN
admet-2756	221	14	less	less	ADJ
admet-2756	221	15	than	than	ADP
admet-2756	221	16	15	15	NUM
admet-2756	221	17	in	in	ADP
admet-2756	221	18	2	2	NUM
admet-2756	221	19	h	h	NOUN
admet-2756	222	1	[	[	X
admet-2756	222	2	48	48	NUM
admet-2756	222	3	]	]	X
admet-2756	222	4	spc	spc	PROPN
admet-2756	222	5	,	,	PUNCT
admet-2756	222	6	cholesterol	cholesterol	PROPN
admet-2756	222	7	,	,	PUNCT
admet-2756	222	8	ddab	ddab	PROPN
admet-2756	222	9	,	,	PUNCT
admet-2756	222	10	peg	peg	NOUN
admet-2756	222	11	-	-	PUNCT
admet-2756	222	12	s	s	NOUN
admet-2756	222	13	106	106	NOUN
admet-2756	222	14	over	over	ADP
admet-2756	222	15	80	80	NUM
admet-2756	222	16	in	in	ADP
admet-2756	222	17	1	1	NUM
admet-2756	222	18	h	h	NOUN
admet-2756	223	1	[	[	X
admet-2756	223	2	46	46	NUM
admet-2756	223	3	]	]	X
admet-2756	223	4	polymeric	polymeric	ADJ
admet-2756	223	5	micelle	micelle	NOUN
admet-2756	223	6	peg	peg	NOUN
admet-2756	223	7	,	,	PUNCT
admet-2756	223	8	pll	pll	PROPN
admet-2756	223	9	63	63	PROPN
admet-2756	223	10	60	60	PROPN
admet-2756	223	11	in	in	ADP
admet-2756	223	12	1	1	NUM
admet-2756	223	13	h	h	NOUN
admet-2756	224	1	[	[	X
admet-2756	224	2	42	42	NUM
admet-2756	224	3	]	]	X
admet-2756	224	4	pullulan	pullulan	NOUN
admet-2756	224	5	,	,	PUNCT
admet-2756	224	6	peg	peg	NOUN
admet-2756	224	7	,	,	PUNCT
admet-2756	224	8	ptx	ptx	VERB
admet-2756	224	9	70	70	PROPN
admet-2756	224	10	over	over	ADP
admet-2756	224	11	40	40	NUM
admet-2756	224	12	in	in	ADP
admet-2756	224	13	1	1	NUM
admet-2756	224	14	h	h	NOUN
admet-2756	225	1	[	[	X
admet-2756	225	2	49	49	NUM
admet-2756	225	3	]	]	PUNCT
admet-2756	225	4	peg	peg	NOUN
admet-2756	225	5	,	,	PUNCT
admet-2756	225	6	dox	dox	NOUN
admet-2756	225	7	114	114	NOUN
admet-2756	226	1	70	70	PROPN
admet-2756	226	2	in	in	ADP
admet-2756	226	3	15	15	NUM
admet-2756	226	4	min	min	NOUN
admet-2756	226	5	[	[	X
admet-2756	226	6	41	41	NUM
admet-2756	226	7	]	]	PUNCT
admet-2756	226	8	acetic	acetic	ADJ
admet-2756	226	9	anhydride	anhydride	NOUN
admet-2756	226	10	,	,	PUNCT
admet-2756	226	11	curcumin	curcumin	NOUN
admet-2756	226	12	161	161	NUM
admet-2756	226	13	55	55	PROPN
admet-2756	226	14	in	in	ADP
admet-2756	226	15	1	1	NUM
admet-2756	226	16	h	h	NOUN
admet-2756	226	17	[	[	X
admet-2756	226	18	50	50	NUM
admet-2756	226	19	]	]	SYM
admet-2756	226	20	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	PROPN
admet-2756	226	21	m.	m.	PROPN
admet-2756	226	22	eshaghi	eshaghi	PROPN
admet-2756	226	23	et	et	PROPN
admet-2756	226	24	al	al	PROPN
admet-2756	226	25	.	.	PROPN
admet-2756	226	26	admet	admet	PROPN
admet-2756	226	27	&	&	CCONJ
admet-2756	226	28	dmpk	dmpk	PROPN
admet-2756	226	29	13(3	13(3	NUM
admet-2756	226	30	)	)	PUNCT
admet-2756	226	31	(	(	PUNCT
admet-2756	226	32	2025	2025	NUM
admet-2756	226	33	)	)	PUNCT
admet-2756	226	34	2756	2756	NUM
admet-2756	226	35	10	10	NUM
admet-2756	226	36	bisphosphonated	bisphosphonate	VERB
admet-2756	226	37	plga	plga	NOUN
admet-2756	226	38	nanoparticles	nanoparticle	NOUN
admet-2756	226	39	nguyen	nguyen	PROPN
admet-2756	226	40	et	et	PROPN
admet-2756	226	41	al	al	PROPN
admet-2756	226	42	.	.	PUNCT
admet-2756	227	1	[	[	X
admet-2756	227	2	51	51	NUM
admet-2756	227	3	]	]	X
admet-2756	227	4	modified	modify	VERB
admet-2756	227	5	plga	plga	NOUN
admet-2756	227	6	nps	nps	PROPN
admet-2756	227	7	with	with	ADP
admet-2756	227	8	aln	aln	PROPN
admet-2756	227	9	for	for	ADP
admet-2756	227	10	bone	bone	NOUN
admet-2756	227	11	-	-	PUNCT
admet-2756	227	12	targeted	target	VERB
admet-2756	227	13	dox	dox	NOUN
admet-2756	227	14	delivery	delivery	NOUN
admet-2756	227	15	.	.	PUNCT
admet-2756	228	1	since	since	SCONJ
admet-2756	228	2	plga	plga	NOUN
admet-2756	228	3	np	np	INTJ
admet-2756	228	4	is	be	AUX
admet-2756	228	5	relatively	relatively	ADV
admet-2756	228	6	hydrophobic	hydrophobic	ADJ
admet-2756	228	7	,	,	PUNCT
admet-2756	228	8	whereas	whereas	SCONJ
admet-2756	228	9	aln	aln	PROPN
admet-2756	228	10	is	be	AUX
admet-2756	228	11	hydrophilic	hydrophilic	ADJ
admet-2756	228	12	,	,	PUNCT
admet-2756	228	13	a	a	DET
admet-2756	228	14	lipid	lipid	NOUN
admet-2756	228	15	was	be	AUX
admet-2756	228	16	conjugated	conjugate	VERB
admet-2756	228	17	to	to	ADP
admet-2756	228	18	aln	aln	PROPN
admet-2756	228	19	to	to	PART
admet-2756	228	20	act	act	VERB
admet-2756	228	21	as	as	ADP
admet-2756	228	22	an	an	DET
admet-2756	228	23	intermediate	intermediate	ADJ
admet-2756	228	24	and	and	CCONJ
admet-2756	228	25	form	form	VERB
admet-2756	228	26	a	a	DET
admet-2756	228	27	stable	stable	ADJ
admet-2756	228	28	aln	aln	NOUN
admet-2756	228	29	corona	corona	PROPN
admet-2756	228	30	on	on	ADP
admet-2756	228	31	the	the	DET
admet-2756	228	32	plga	plga	NOUN
admet-2756	228	33	np	np	INTJ
admet-2756	228	34	surface	surface	NOUN
admet-2756	228	35	.	.	PUNCT
admet-2756	229	1	this	this	DET
admet-2756	229	2	nanocarrier	nanocarrier	NOUN
admet-2756	229	3	yielded	yield	VERB
admet-2756	229	4	high	high	ADJ
admet-2756	229	5	loading	loading	NOUN
admet-2756	229	6	efficiency	efficiency	NOUN
admet-2756	229	7	(	(	PUNCT
admet-2756	229	8	>	>	SYM
admet-2756	229	9	80	80	NUM
admet-2756	229	10	%	%	NOUN
admet-2756	229	11	)	)	PUNCT
admet-2756	229	12	.	.	PUNCT
admet-2756	230	1	in	in	ADP
admet-2756	230	2	vitro	vitro	X
admet-2756	230	3	hap	hap	X
admet-2756	230	4	binding	bind	VERB
admet-2756	230	5	assay	assay	NOUN
admet-2756	230	6	revealed	reveal	VERB
admet-2756	230	7	that	that	SCONJ
admet-2756	230	8	aln	aln	PROPN
admet-2756	230	9	-	-	PUNCT
admet-2756	230	10	modified	modify	VERB
admet-2756	230	11	nps	nps	PROPN
admet-2756	230	12	yield	yield	VERB
admet-2756	230	13	maximum	maximum	ADJ
admet-2756	230	14	hap	hap	NOUN
admet-2756	230	15	binding	binding	NOUN
admet-2756	230	16	when	when	SCONJ
admet-2756	230	17	used	use	VERB
admet-2756	230	18	at	at	ADP
admet-2756	230	19	an	an	DET
admet-2756	230	20	optimum	optimum	ADJ
admet-2756	230	21	concentration	concentration	NOUN
admet-2756	230	22	.	.	PUNCT
admet-2756	231	1	at	at	ADP
admet-2756	231	2	a	a	DET
admet-2756	231	3	concentration	concentration	NOUN
admet-2756	231	4	of	of	ADP
admet-2756	231	5	100	100	NUM
admet-2756	231	6	µg	µg	ADV
admet-2756	231	7	ml-1	ml-1	X
admet-2756	231	8	,	,	PUNCT
admet-2756	231	9	80	80	NUM
admet-2756	231	10	%	%	NOUN
admet-2756	231	11	binding	binding	NOUN
admet-2756	231	12	was	be	AUX
admet-2756	231	13	achieved	achieve	VERB
admet-2756	231	14	,	,	PUNCT
admet-2756	231	15	whereas	whereas	SCONJ
admet-2756	231	16	increasing	increase	VERB
admet-2756	231	17	the	the	DET
admet-2756	231	18	concentration	concentration	NOUN
admet-2756	231	19	to	to	ADP
admet-2756	231	20	1	1	NUM
admet-2756	231	21	µg	µg	ADV
admet-2756	231	22	ml-1	ml-1	CCONJ
admet-2756	231	23	reduced	reduce	VERB
admet-2756	231	24	the	the	DET
admet-2756	231	25	binding	bind	VERB
admet-2756	231	26	to	to	ADP
admet-2756	231	27	20	20	NUM
admet-2756	231	28	%	%	NOUN
admet-2756	231	29	.	.	PUNCT
admet-2756	232	1	therefore	therefore	ADV
admet-2756	232	2	,	,	PUNCT
admet-2756	232	3	an	an	DET
admet-2756	232	4	optimized	optimize	VERB
admet-2756	232	5	concentration	concentration	NOUN
admet-2756	232	6	of	of	ADP
admet-2756	232	7	nps	nps	PROPN
admet-2756	232	8	should	should	AUX
admet-2756	232	9	be	be	AUX
admet-2756	232	10	used	use	VERB
admet-2756	232	11	to	to	PART
admet-2756	232	12	obtain	obtain	VERB
admet-2756	232	13	maximum	maximum	ADJ
admet-2756	232	14	hap	hap	ADJ
admet-2756	232	15	binding	binding	NOUN
admet-2756	232	16	.	.	PUNCT
admet-2756	233	1	kozlu	kozlu	PROPN
admet-2756	233	2	et	et	PROPN
admet-2756	233	3	al	al	PROPN
admet-2756	233	4	.	.	PUNCT
admet-2756	234	1	[	[	X
admet-2756	234	2	52	52	NUM
admet-2756	234	3	]	]	PUNCT
admet-2756	234	4	used	use	VERB
admet-2756	234	5	aln	aln	PROPN
admet-2756	234	6	-	-	PUNCT
admet-2756	234	7	modified	modify	VERB
admet-2756	234	8	plga	plga	NOUN
admet-2756	234	9	nanoparticles	nanoparticle	NOUN
admet-2756	234	10	for	for	ADP
admet-2756	234	11	co	co	NOUN
admet-2756	234	12	-	-	NOUN
admet-2756	234	13	delivery	delivery	NOUN
admet-2756	234	14	of	of	ADP
admet-2756	234	15	dox	dox	NOUN
admet-2756	234	16	and	and	CCONJ
admet-2756	234	17	celecoxib	celecoxib	PROPN
admet-2756	234	18	(	(	PUNCT
admet-2756	234	19	cxb	cxb	NOUN
admet-2756	234	20	)	)	PUNCT
admet-2756	234	21	.	.	PUNCT
admet-2756	235	1	dox	dox	NOUN
admet-2756	235	2	and	and	CCONJ
admet-2756	235	3	cxb	cxb	NOUN
admet-2756	235	4	have	have	AUX
admet-2756	235	5	been	be	AUX
admet-2756	235	6	shown	show	VERB
admet-2756	235	7	to	to	PART
admet-2756	235	8	possess	possess	VERB
admet-2756	235	9	synergistic	synergistic	ADJ
admet-2756	235	10	anticancer	anticancer	NOUN
admet-2756	235	11	properties	property	NOUN
admet-2756	235	12	.	.	PUNCT
admet-2756	236	1	in	in	ADP
admet-2756	236	2	vitro	vitro	X
admet-2756	236	3	hap	hap	X
admet-2756	236	4	binding	bind	VERB
admet-2756	236	5	assay	assay	PROPN
admet-2756	236	6	confirmed	confirm	VERB
admet-2756	236	7	that	that	SCONJ
admet-2756	236	8	the	the	DET
admet-2756	236	9	bone	bone	NOUN
admet-2756	236	10	affinity	affinity	NOUN
admet-2756	236	11	of	of	ADP
admet-2756	236	12	aln	aln	PROPN
admet-2756	236	13	is	be	AUX
admet-2756	236	14	not	not	PART
admet-2756	236	15	compromised	compromise	VERB
admet-2756	236	16	as	as	ADP
admet-2756	236	17	a	a	DET
admet-2756	236	18	result	result	NOUN
admet-2756	236	19	of	of	ADP
admet-2756	236	20	conjugation	conjugation	NOUN
admet-2756	236	21	with	with	ADP
admet-2756	236	22	plga	plga	PROPN
admet-2756	236	23	nps	nps	PROPN
admet-2756	236	24	.	.	PUNCT
admet-2756	237	1	also	also	ADV
admet-2756	237	2	,	,	PUNCT
admet-2756	237	3	increasing	increase	VERB
admet-2756	237	4	the	the	DET
admet-2756	237	5	surface	surface	NOUN
admet-2756	237	6	density	density	NOUN
admet-2756	237	7	of	of	ADP
admet-2756	237	8	aln	aln	PROPN
admet-2756	237	9	improved	improve	VERB
admet-2756	237	10	hap	hap	NOUN
admet-2756	237	11	binding	bind	VERB
admet-2756	237	12	to	to	ADP
admet-2756	237	13	a	a	DET
admet-2756	237	14	certain	certain	ADJ
admet-2756	237	15	extent	extent	NOUN
admet-2756	237	16	,	,	PUNCT
admet-2756	237	17	and	and	CCONJ
admet-2756	237	18	beyond	beyond	ADP
admet-2756	237	19	a	a	DET
admet-2756	237	20	certain	certain	ADJ
admet-2756	237	21	concentration	concentration	NOUN
admet-2756	237	22	of	of	ADP
admet-2756	237	23	aln	aln	PROPN
admet-2756	237	24	,	,	PUNCT
admet-2756	237	25	the	the	DET
admet-2756	237	26	affinity	affinity	NOUN
admet-2756	237	27	figure	figure	NOUN
admet-2756	237	28	plateaued	plateaue	VERB
admet-2756	237	29	.	.	PUNCT
admet-2756	238	1	similar	similar	ADJ
admet-2756	238	2	to	to	ADP
admet-2756	238	3	the	the	DET
admet-2756	238	4	work	work	NOUN
admet-2756	238	5	of	of	ADP
admet-2756	238	6	wu	wu	PROPN
admet-2756	238	7	et	et	PROPN
admet-2756	238	8	al	al	PROPN
admet-2756	238	9	.	.	PUNCT
admet-2756	239	1	[	[	X
admet-2756	239	2	46	46	NUM
admet-2756	239	3	]	]	PUNCT
admet-2756	239	4	,	,	PUNCT
admet-2756	239	5	this	this	DET
admet-2756	239	6	report	report	NOUN
admet-2756	239	7	verifies	verify	VERB
admet-2756	239	8	that	that	SCONJ
admet-2756	239	9	the	the	DET
admet-2756	239	10	density	density	NOUN
admet-2756	239	11	of	of	ADP
admet-2756	239	12	bp	bp	PROPN
admet-2756	239	13	corona	corona	PROPN
admet-2756	239	14	on	on	ADP
admet-2756	239	15	the	the	DET
admet-2756	239	16	nanocarrier	nanocarrier	NOUN
admet-2756	239	17	surface	surface	NOUN
admet-2756	239	18	should	should	AUX
admet-2756	239	19	be	be	AUX
admet-2756	239	20	optimized	optimize	VERB
admet-2756	239	21	for	for	ADP
admet-2756	239	22	maximal	maximal	ADJ
admet-2756	239	23	bone	bone	NOUN
admet-2756	239	24	targeting	targeting	NOUN
admet-2756	239	25	and	and	CCONJ
admet-2756	239	26	excessive	excessive	ADJ
admet-2756	239	27	surface	surface	NOUN
admet-2756	239	28	modification	modification	NOUN
admet-2756	239	29	can	can	AUX
admet-2756	239	30	yield	yield	VERB
admet-2756	239	31	opposite	opposite	ADJ
admet-2756	239	32	results	result	NOUN
admet-2756	239	33	.	.	PUNCT
admet-2756	240	1	yuan	yuan	NOUN
admet-2756	240	2	et	et	PROPN
admet-2756	240	3	al	al	PROPN
admet-2756	240	4	.	.	PUNCT
admet-2756	241	1	[	[	X
admet-2756	241	2	53	53	NUM
admet-2756	241	3	]	]	PUNCT
admet-2756	241	4	used	use	VERB
admet-2756	241	5	zoledronate	zoledronate	PROPN
admet-2756	241	6	(	(	PUNCT
admet-2756	241	7	zol)-functionalized	zol)-functionalize	VERB
admet-2756	241	8	plga	plga	NOUN
admet-2756	241	9	nps	nps	PROPN
admet-2756	241	10	for	for	ADP
admet-2756	241	11	co	co	NOUN
admet-2756	241	12	-	-	NOUN
admet-2756	241	13	delivery	delivery	NOUN
admet-2756	241	14	of	of	ADP
admet-2756	241	15	gemcitabine	gemcitabine	NOUN
admet-2756	241	16	(	(	PUNCT
admet-2756	241	17	gcb	gcb	PROPN
admet-2756	241	18	)	)	PUNCT
admet-2756	241	19	and	and	CCONJ
admet-2756	241	20	epirubicin	epirubicin	PROPN
admet-2756	241	21	(	(	PUNCT
admet-2756	241	22	epb	epb	PROPN
admet-2756	241	23	)	)	PUNCT
admet-2756	241	24	.	.	PUNCT
admet-2756	242	1	while	while	SCONJ
admet-2756	242	2	gcb	gcb	PROPN
admet-2756	242	3	is	be	AUX
admet-2756	242	4	used	use	VERB
admet-2756	242	5	as	as	ADP
admet-2756	242	6	a	a	DET
admet-2756	242	7	first	first	ADJ
admet-2756	242	8	-	-	PUNCT
admet-2756	242	9	line	line	NOUN
admet-2756	242	10	treatment	treatment	NOUN
admet-2756	242	11	,	,	PUNCT
admet-2756	242	12	epb	epb	PROPN
admet-2756	242	13	was	be	AUX
admet-2756	242	14	added	add	VERB
admet-2756	242	15	due	due	ADP
admet-2756	242	16	to	to	ADP
admet-2756	242	17	its	its	PRON
admet-2756	242	18	wider	wide	ADJ
admet-2756	242	19	therapeutic	therapeutic	ADJ
admet-2756	242	20	window	window	NOUN
admet-2756	242	21	.	.	PUNCT
admet-2756	243	1	according	accord	VERB
admet-2756	243	2	to	to	ADP
admet-2756	243	3	in	in	ADP
admet-2756	243	4	vitro	vitro	X
admet-2756	243	5	experiments	experiment	NOUN
admet-2756	243	6	,	,	PUNCT
admet-2756	243	7	zol	zol	VERB
admet-2756	243	8	-	-	PUNCT
admet-2756	243	9	functionalized	functionalize	VERB
admet-2756	243	10	nps	nps	PROPN
admet-2756	243	11	had	have	VERB
admet-2756	243	12	almost	almost	ADV
admet-2756	243	13	as	as	ADV
admet-2756	243	14	much	much	ADJ
admet-2756	243	15	affinity	affinity	NOUN
admet-2756	243	16	for	for	ADP
admet-2756	243	17	bone	bone	NOUN
admet-2756	243	18	powder	powder	NOUN
admet-2756	243	19	as	as	ADP
admet-2756	243	20	pure	pure	ADJ
admet-2756	243	21	zol	zol	NOUN
admet-2756	243	22	.	.	PUNCT
admet-2756	244	1	this	this	DET
admet-2756	244	2	affinity	affinity	NOUN
admet-2756	244	3	also	also	ADV
admet-2756	244	4	increased	increase	VERB
admet-2756	244	5	with	with	ADP
admet-2756	244	6	time	time	NOUN
admet-2756	244	7	.	.	PUNCT
admet-2756	245	1	after	after	ADP
admet-2756	245	2	2	2	NUM
admet-2756	245	3	and	and	CCONJ
admet-2756	245	4	8	8	NUM
admet-2756	245	5	hours	hour	NOUN
admet-2756	245	6	of	of	ADP
admet-2756	245	7	incubation	incubation	NOUN
admet-2756	245	8	with	with	ADP
admet-2756	245	9	hap	hap	NOUN
admet-2756	245	10	,	,	PUNCT
admet-2756	245	11	the	the	DET
admet-2756	245	12	binding	bind	VERB
admet-2756	245	13	percentage	percentage	NOUN
admet-2756	245	14	was	be	AUX
admet-2756	245	15	roughly	roughly	ADV
admet-2756	245	16	50	50	NUM
admet-2756	245	17	and	and	CCONJ
admet-2756	245	18	90	90	NUM
admet-2756	245	19	%	%	NOUN
admet-2756	245	20	,	,	PUNCT
admet-2756	245	21	respectively	respectively	ADV
admet-2756	245	22	.	.	PUNCT
admet-2756	246	1	these	these	DET
admet-2756	246	2	reports	report	NOUN
admet-2756	246	3	verify	verify	VERB
admet-2756	246	4	that	that	SCONJ
admet-2756	246	5	modifying	modify	VERB
admet-2756	246	6	plga	plga	NOUN
admet-2756	246	7	nps	nps	PROPN
admet-2756	246	8	with	with	ADP
admet-2756	246	9	bps	bps	NOUN
admet-2756	246	10	does	do	AUX
admet-2756	246	11	not	not	PART
admet-2756	246	12	affect	affect	VERB
admet-2756	246	13	the	the	DET
admet-2756	246	14	bone	bone	NOUN
admet-2756	246	15	-	-	PUNCT
admet-2756	246	16	targeting	target	VERB
admet-2756	246	17	property	property	NOUN
admet-2756	246	18	of	of	ADP
admet-2756	246	19	the	the	DET
admet-2756	246	20	latter	latter	ADJ
admet-2756	246	21	.	.	PUNCT
admet-2756	247	1	since	since	SCONJ
admet-2756	247	2	plga	plga	NOUN
admet-2756	247	3	is	be	AUX
admet-2756	247	4	fda	fda	PROPN
admet-2756	247	5	-	-	PUNCT
admet-2756	247	6	approved	approve	VERB
admet-2756	247	7	for	for	ADP
admet-2756	247	8	many	many	ADJ
admet-2756	247	9	biomedical	biomedical	ADJ
admet-2756	247	10	applications	application	NOUN
admet-2756	247	11	,	,	PUNCT
admet-2756	247	12	and	and	CCONJ
admet-2756	247	13	considering	consider	VERB
admet-2756	247	14	maintaining	maintain	VERB
admet-2756	247	15	the	the	DET
admet-2756	247	16	bone	bone	NOUN
admet-2756	247	17	affinity	affinity	NOUN
admet-2756	247	18	of	of	ADP
admet-2756	247	19	bps	bps	NOUN
admet-2756	247	20	despite	despite	SCONJ
admet-2756	247	21	covalent	covalent	ADJ
admet-2756	247	22	conjugation	conjugation	NOUN
admet-2756	247	23	with	with	ADP
admet-2756	247	24	plga	plga	NOUN
admet-2756	247	25	,	,	PUNCT
admet-2756	247	26	bp	bp	PROPN
admet-2756	247	27	-	-	PUNCT
admet-2756	247	28	modified	modify	VERB
admet-2756	247	29	plga	plga	NOUN
admet-2756	247	30	nps	nps	PROPN
admet-2756	247	31	hold	hold	VERB
admet-2756	247	32	promise	promise	NOUN
admet-2756	247	33	for	for	ADP
admet-2756	247	34	developing	develop	VERB
admet-2756	247	35	drug	drug	NOUN
admet-2756	247	36	delivery	delivery	NOUN
admet-2756	247	37	systems	system	NOUN
admet-2756	247	38	for	for	ADP
admet-2756	247	39	bone	bone	NOUN
admet-2756	247	40	tumours	tumour	NOUN
admet-2756	247	41	.	.	PUNCT
admet-2756	248	1	figure	figure	NOUN
admet-2756	248	2	5	5	NUM
admet-2756	248	3	demonstrates	demonstrate	VERB
admet-2756	248	4	different	different	ADJ
admet-2756	248	5	approaches	approach	NOUN
admet-2756	248	6	for	for	ADP
admet-2756	248	7	modifying	modify	VERB
admet-2756	248	8	plga	plga	NOUN
admet-2756	248	9	nps	nps	PROPN
admet-2756	248	10	with	with	ADP
admet-2756	248	11	bps	bps	PROPN
admet-2756	248	12	.	.	PUNCT
admet-2756	248	13	figure	figure	NOUN
admet-2756	248	14	5	5	NUM
admet-2756	248	15	.	.	PUNCT
admet-2756	248	16	strategies	strategy	NOUN
admet-2756	248	17	for	for	ADP
admet-2756	248	18	functionalizing	functionalizing	ADJ
admet-2756	248	19	plga	plga	NOUN
admet-2756	248	20	nps	nps	PROPN
admet-2756	248	21	with	with	ADP
admet-2756	248	22	bps	bps	NOUN
admet-2756	248	23	key	key	NOUN
admet-2756	248	24	advantages	advantage	NOUN
admet-2756	248	25	and	and	CCONJ
admet-2756	248	26	limitations	limitation	NOUN
admet-2756	248	27	of	of	ADP
admet-2756	248	28	bp	bp	NOUN
admet-2756	248	29	-	-	PUNCT
admet-2756	248	30	functionalized	functionalize	VERB
admet-2756	248	31	drug	drug	NOUN
admet-2756	248	32	delivery	delivery	NOUN
admet-2756	248	33	systems	system	NOUN
admet-2756	248	34	each	each	DET
admet-2756	248	35	class	class	NOUN
admet-2756	248	36	of	of	ADP
admet-2756	248	37	drug	drug	NOUN
admet-2756	248	38	delivery	delivery	NOUN
admet-2756	248	39	systems	system	NOUN
admet-2756	248	40	reviewed	review	VERB
admet-2756	248	41	in	in	ADP
admet-2756	248	42	the	the	DET
admet-2756	248	43	previous	previous	ADJ
admet-2756	248	44	sections	section	NOUN
admet-2756	248	45	exhibited	exhibit	VERB
admet-2756	248	46	certain	certain	ADJ
admet-2756	248	47	advantages	advantage	NOUN
admet-2756	248	48	and	and	CCONJ
admet-2756	248	49	disadvantages	disadvantage	NOUN
admet-2756	248	50	.	.	PUNCT
admet-2756	249	1	most	most	ADJ
admet-2756	249	2	of	of	ADP
admet-2756	249	3	these	these	DET
admet-2756	249	4	achievements	achievement	NOUN
admet-2756	249	5	are	be	AUX
admet-2756	249	6	the	the	DET
admet-2756	249	7	consequence	consequence	NOUN
admet-2756	249	8	of	of	ADP
admet-2756	249	9	structural	structural	ADJ
admet-2756	249	10	and	and	CCONJ
admet-2756	249	11	organizational	organizational	ADJ
admet-2756	249	12	admet	admet	NOUN
admet-2756	249	13	&	&	CCONJ
admet-2756	249	14	dmpk	dmpk	PROPN
admet-2756	249	15	13(3	13(3	NUM
admet-2756	249	16	)	)	PUNCT
admet-2756	249	17	(	(	PUNCT
admet-2756	249	18	2025	2025	NUM
admet-2756	249	19	)	)	PUNCT
admet-2756	249	20	2756	2756	NUM
admet-2756	249	21	bisphosphonates	bisphosphonate	NOUN
admet-2756	249	22	for	for	ADP
admet-2756	249	23	bone	bone	NOUN
admet-2756	249	24	cancer	cancer	NOUN
admet-2756	249	25	therapy	therapy	NOUN
admet-2756	249	26	doi	doi	NOUN
admet-2756	249	27	:	:	PUNCT
admet-2756	249	28	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	249	29	11	11	NUM
admet-2756	249	30	relationships	relationship	NOUN
admet-2756	249	31	between	between	ADP
admet-2756	249	32	bp	bp	PROPN
admet-2756	249	33	molecules	molecule	NOUN
admet-2756	249	34	and	and	CCONJ
admet-2756	249	35	other	other	ADJ
admet-2756	249	36	components	component	NOUN
admet-2756	249	37	of	of	ADP
admet-2756	249	38	drug	drug	NOUN
admet-2756	249	39	delivery	delivery	NOUN
admet-2756	249	40	systems	system	NOUN
admet-2756	249	41	.	.	PUNCT
admet-2756	250	1	table	table	NOUN
admet-2756	250	2	6	6	NUM
admet-2756	250	3	summarizes	summarize	NOUN
admet-2756	250	4	distinguished	distinguished	ADJ
admet-2756	250	5	achievements	achievement	NOUN
admet-2756	250	6	and	and	CCONJ
admet-2756	250	7	unignorable	unignorable	ADJ
admet-2756	250	8	drawbacks	drawback	NOUN
admet-2756	250	9	of	of	ADP
admet-2756	250	10	the	the	DET
admet-2756	250	11	discussed	discuss	VERB
admet-2756	250	12	literature	literature	NOUN
admet-2756	250	13	reports	report	NOUN
admet-2756	250	14	.	.	PUNCT
admet-2756	251	1	considering	consider	VERB
admet-2756	251	2	all	all	DET
admet-2756	251	3	aspects	aspect	NOUN
admet-2756	251	4	of	of	ADP
admet-2756	251	5	the	the	DET
admet-2756	251	6	reviewed	review	VERB
admet-2756	251	7	literature	literature	NOUN
admet-2756	251	8	,	,	PUNCT
admet-2756	251	9	it	it	PRON
admet-2756	251	10	could	could	AUX
admet-2756	251	11	be	be	AUX
admet-2756	251	12	concluded	conclude	VERB
admet-2756	251	13	that	that	SCONJ
admet-2756	251	14	bps	bps	NOUN
admet-2756	251	15	improve	improve	VERB
admet-2756	251	16	the	the	DET
admet-2756	251	17	bone	bone	NOUN
admet-2756	251	18	-	-	PUNCT
admet-2756	251	19	targeting	target	VERB
admet-2756	251	20	efficiency	efficiency	NOUN
admet-2756	251	21	and	and	CCONJ
admet-2756	251	22	consequently	consequently	ADV
admet-2756	251	23	therapeutic	therapeutic	ADJ
admet-2756	251	24	efficiency	efficiency	NOUN
admet-2756	251	25	of	of	ADP
admet-2756	251	26	all	all	DET
admet-2756	251	27	drug	drug	NOUN
admet-2756	251	28	delivery	delivery	NOUN
admet-2756	251	29	systems	system	NOUN
admet-2756	251	30	for	for	ADP
admet-2756	251	31	treating	treat	VERB
admet-2756	251	32	bone	bone	NOUN
admet-2756	251	33	-	-	PUNCT
admet-2756	251	34	related	relate	VERB
admet-2756	251	35	cancers	cancer	NOUN
admet-2756	251	36	,	,	PUNCT
admet-2756	251	37	regardless	regardless	ADV
admet-2756	251	38	of	of	ADP
admet-2756	251	39	the	the	DET
admet-2756	251	40	type	type	NOUN
admet-2756	251	41	of	of	ADP
admet-2756	251	42	carrier	carrier	NOUN
admet-2756	251	43	.	.	PUNCT
admet-2756	252	1	however	however	ADV
admet-2756	252	2	,	,	PUNCT
admet-2756	252	3	focusing	focus	VERB
admet-2756	252	4	on	on	ADP
admet-2756	252	5	some	some	DET
admet-2756	252	6	carriers	carrier	NOUN
admet-2756	252	7	such	such	ADJ
admet-2756	252	8	as	as	ADP
admet-2756	252	9	plga	plga	NOUN
admet-2756	252	10	and	and	CCONJ
admet-2756	252	11	liposomes	liposome	NOUN
admet-2756	252	12	,	,	PUNCT
admet-2756	252	13	which	which	PRON
admet-2756	252	14	are	be	AUX
admet-2756	252	15	already	already	ADV
admet-2756	252	16	cleared	clear	VERB
admet-2756	252	17	by	by	ADP
admet-2756	252	18	the	the	DET
admet-2756	252	19	fda	fda	PROPN
admet-2756	252	20	for	for	ADP
admet-2756	252	21	biomedical	biomedical	ADJ
admet-2756	252	22	applications	application	NOUN
admet-2756	252	23	,	,	PUNCT
admet-2756	252	24	could	could	AUX
admet-2756	252	25	accelerate	accelerate	VERB
admet-2756	252	26	the	the	DET
admet-2756	252	27	process	process	NOUN
admet-2756	252	28	and	and	CCONJ
admet-2756	252	29	increase	increase	VERB
admet-2756	252	30	the	the	DET
admet-2756	252	31	chances	chance	NOUN
admet-2756	252	32	of	of	ADP
admet-2756	252	33	successfully	successfully	ADV
admet-2756	252	34	passing	pass	VERB
admet-2756	252	35	clinical	clinical	ADJ
admet-2756	252	36	trials	trial	NOUN
admet-2756	252	37	and	and	CCONJ
admet-2756	252	38	receiving	receive	VERB
admet-2756	252	39	a	a	DET
admet-2756	252	40	final	final	ADJ
admet-2756	252	41	fda	fda	PROPN
admet-2756	252	42	-	-	PUNCT
admet-2756	252	43	approved	approve	VERB
admet-2756	252	44	product	product	NOUN
admet-2756	252	45	.	.	PUNCT
admet-2756	253	1	table	table	NOUN
admet-2756	253	2	6	6	NUM
admet-2756	253	3	.	.	PUNCT
admet-2756	254	1	distinguished	distinguished	ADJ
admet-2756	254	2	achievements	achievement	NOUN
admet-2756	254	3	and	and	CCONJ
admet-2756	254	4	drawbacks	drawback	NOUN
admet-2756	254	5	of	of	ADP
admet-2756	254	6	the	the	DET
admet-2756	254	7	bps	bps	NOUN
admet-2756	254	8	-	-	PUNCT
admet-2756	254	9	functionalized	functionalize	VERB
admet-2756	254	10	drug	drug	NOUN
admet-2756	254	11	delivery	delivery	NOUN
admet-2756	254	12	systems	system	NOUN
admet-2756	254	13	drug	drug	NOUN
admet-2756	254	14	delivery	delivery	NOUN
admet-2756	254	15	system	system	NOUN
admet-2756	254	16	type	type	NOUN
admet-2756	254	17	distinguished	distinguished	ADJ
admet-2756	254	18	achievements	achievement	NOUN
admet-2756	254	19	unignorable	unignorable	ADJ
admet-2756	254	20	drawbacks	drawback	NOUN
admet-2756	254	21	ref	ref	VERB
admet-2756	254	22	.	.	PUNCT
admet-2756	255	1	bp	bp	PROPN
admet-2756	255	2	-	-	PUNCT
admet-2756	255	3	drug	drug	NOUN
admet-2756	255	4	conjugate	conjugate	NOUN
admet-2756	255	5	(	(	PUNCT
admet-2756	255	6	12b80	12b80	NUM
admet-2756	255	7	/	/	SYM
admet-2756	255	8	dox	dox	NOUN
admet-2756	255	9	)	)	PUNCT
admet-2756	255	10	outstandingly	outstandingly	ADV
admet-2756	255	11	sustained	sustain	VERB
admet-2756	255	12	release	release	NOUN
admet-2756	255	13	profile	profile	NOUN
admet-2756	255	14	,	,	PUNCT
admet-2756	255	15	which	which	PRON
admet-2756	255	16	improved	improve	VERB
admet-2756	255	17	therapeutic	therapeutic	ADJ
admet-2756	255	18	efficiency	efficiency	NOUN
admet-2756	255	19	of	of	ADP
admet-2756	255	20	the	the	DET
admet-2756	255	21	drug	drug	NOUN
admet-2756	255	22	,	,	PUNCT
admet-2756	255	23	successful	successful	ADJ
admet-2756	255	24	modulation	modulation	NOUN
admet-2756	255	25	of	of	ADP
admet-2756	255	26	linker	linker	NOUN
admet-2756	255	27	degradation	degradation	NOUN
admet-2756	255	28	rate	rate	NOUN
admet-2756	255	29	unsuccessful	unsuccessful	ADJ
admet-2756	255	30	in	in	ADP
admet-2756	255	31	decreasing	decrease	VERB
admet-2756	255	32	tumour	tumour	NOUN
admet-2756	255	33	volume	volume	NOUN
admet-2756	255	34	in	in	ADP
admet-2756	255	35	vivo	vivo	NOUN
admet-2756	255	36	[	[	X
admet-2756	255	37	23	23	NUM
admet-2756	255	38	]	]	SYM
admet-2756	255	39	bp	bp	PROPN
admet-2756	255	40	-	-	PUNCT
admet-2756	255	41	drug	drug	NOUN
admet-2756	255	42	conjugate	conjugate	NOUN
admet-2756	255	43	(	(	PUNCT
admet-2756	255	44	bp15/	bp15/	NOUN
admet-2756	255	45	pt(no3)2(en	pt(no3)2(en	NOUN
admet-2756	255	46	)	)	PUNCT
admet-2756	255	47	)	)	PUNCT
admet-2756	255	48	selective	selective	ADJ
admet-2756	255	49	accumulation	accumulation	NOUN
admet-2756	255	50	in	in	ADP
admet-2756	255	51	bone	bone	NOUN
admet-2756	255	52	with	with	ADP
admet-2756	255	53	higher	high	ADJ
admet-2756	255	54	metabolic	metabolic	NOUN
admet-2756	255	55	activity	activity	NOUN
admet-2756	255	56	limited	limit	VERB
admet-2756	255	57	worldwide	worldwide	ADJ
admet-2756	255	58	availability	availability	NOUN
admet-2756	255	59	of	of	ADP
admet-2756	255	60	raw	raw	ADJ
admet-2756	255	61	materials	material	NOUN
admet-2756	255	62	[	[	X
admet-2756	255	63	17	17	NUM
admet-2756	255	64	]	]	SYM
admet-2756	255	65	bp	bp	PROPN
admet-2756	255	66	-	-	PUNCT
admet-2756	255	67	drug	drug	NOUN
admet-2756	255	68	conjugate	conjugate	NOUN
admet-2756	255	69	(	(	PUNCT
admet-2756	255	70	bp22	bp22	PROPN
admet-2756	255	71	/	/	SYM
admet-2756	255	72	btz	btz	PROPN
admet-2756	255	73	)	)	PUNCT
admet-2756	255	74	successful	successful	ADJ
admet-2756	255	75	modulation	modulation	NOUN
admet-2756	255	76	of	of	ADP
admet-2756	255	77	linker	linker	NOUN
admet-2756	255	78	degradation	degradation	NOUN
admet-2756	255	79	rate	rate	NOUN
admet-2756	255	80	,	,	PUNCT
admet-2756	255	81	serum	serum	NOUN
admet-2756	255	82	stability	stability	NOUN
admet-2756	255	83	,	,	PUNCT
admet-2756	255	84	delayed	delay	VERB
admet-2756	255	85	clearance	clearance	NOUN
admet-2756	255	86	from	from	ADP
admet-2756	255	87	well	well	ADV
admet-2756	255	88	-	-	PUNCT
admet-2756	255	89	perfused	perfuse	VERB
admet-2756	255	90	bone	bone	NOUN
admet-2756	255	91	marrow	marrow	NOUN
admet-2756	256	1	[	[	X
admet-2756	256	2	24	24	NUM
admet-2756	256	3	]	]	SYM
admet-2756	256	4	ca	ca	NOUN
admet-2756	256	5	-	-	PUNCT
admet-2756	256	6	based	base	VERB
admet-2756	256	7	system	system	NOUN
admet-2756	256	8	(	(	PUNCT
admet-2756	256	9	hap	hap	PROPN
admet-2756	256	10	/	/	SYM
admet-2756	256	11	aln	aln	PROPN
admet-2756	256	12	/	/	SYM
admet-2756	256	13	ibf	ibf	PROPN
admet-2756	256	14	)	)	PUNCT
admet-2756	256	15	very	very	ADV
admet-2756	256	16	high	high	ADJ
admet-2756	256	17	encapsulation	encapsulation	NOUN
admet-2756	256	18	efficiency	efficiency	NOUN
admet-2756	256	19	despite	despite	SCONJ
admet-2756	256	20	the	the	DET
admet-2756	256	21	opposite	opposite	ADJ
admet-2756	256	22	nature	nature	NOUN
admet-2756	256	23	of	of	ADP
admet-2756	256	24	drug	drug	NOUN
admet-2756	256	25	and	and	CCONJ
admet-2756	256	26	carrier	carrier	NOUN
admet-2756	256	27	(	(	PUNCT
admet-2756	256	28	hydrophobic	hydrophobic	NOUN
admet-2756	256	29	/	/	SYM
admet-2756	256	30	hydrophilic	hydrophilic	NOUN
admet-2756	256	31	)	)	PUNCT
admet-2756	256	32	,	,	PUNCT
admet-2756	256	33	which	which	PRON
admet-2756	256	34	is	be	AUX
admet-2756	256	35	achieved	achieve	VERB
admet-2756	256	36	because	because	SCONJ
admet-2756	256	37	of	of	ADP
admet-2756	256	38	aln	aln	PROPN
admet-2756	256	39	huge	huge	ADJ
admet-2756	256	40	burst	burst	NOUN
admet-2756	256	41	release	release	NOUN
admet-2756	256	42	due	due	ADP
admet-2756	256	43	to	to	ADP
admet-2756	256	44	opposite	opposite	ADJ
admet-2756	256	45	nature	nature	NOUN
admet-2756	256	46	of	of	ADP
admet-2756	256	47	drug	drug	NOUN
admet-2756	256	48	and	and	CCONJ
admet-2756	256	49	carrier	carrier	NOUN
admet-2756	256	50	[	[	X
admet-2756	256	51	28	28	NUM
admet-2756	256	52	]	]	X
admet-2756	256	53	ca	ca	NOUN
admet-2756	256	54	-	-	PUNCT
admet-2756	256	55	based	base	VERB
admet-2756	256	56	system	system	NOUN
admet-2756	256	57	(	(	PUNCT
admet-2756	256	58	bg	bg	NOUN
admet-2756	256	59	/	/	SYM
admet-2756	256	60	ha	ha	PROPN
admet-2756	256	61	/	/	SYM
admet-2756	256	62	aln	aln	PROPN
admet-2756	256	63	/	/	SYM
admet-2756	256	64	dox	dox	NOUN
admet-2756	256	65	)	)	PUNCT
admet-2756	256	66	controlled	control	VERB
admet-2756	256	67	degradation	degradation	NOUN
admet-2756	256	68	rate	rate	NOUN
admet-2756	256	69	by	by	ADP
admet-2756	256	70	addition	addition	NOUN
admet-2756	256	71	of	of	ADP
admet-2756	256	72	ha	ha	ADJ
admet-2756	256	73	-	-	PUNCT
admet-2756	256	74	aln	aln	PROPN
admet-2756	256	75	ligand	ligand	NOUN
admet-2756	256	76	and	and	CCONJ
admet-2756	256	77	consequent	consequent	ADJ
admet-2756	256	78	control	control	NOUN
admet-2756	256	79	over	over	ADP
admet-2756	256	80	release	release	NOUN
admet-2756	256	81	pattern	pattern	NOUN
admet-2756	256	82	despite	despite	SCONJ
admet-2756	256	83	the	the	DET
admet-2756	256	84	acid	acid	NOUN
admet-2756	256	85	-	-	PUNCT
admet-2756	256	86	sensitivity	sensitivity	NOUN
admet-2756	256	87	of	of	ADP
admet-2756	256	88	bg	bg	PROPN
admet-2756	256	89	nps	nps	PROPN
admet-2756	256	90	,	,	PUNCT
admet-2756	256	91	around	around	ADP
admet-2756	256	92	50	50	NUM
admet-2756	256	93	%	%	NOUN
admet-2756	256	94	of	of	ADP
admet-2756	256	95	the	the	DET
admet-2756	256	96	drug	drug	NOUN
admet-2756	256	97	was	be	AUX
admet-2756	256	98	released	release	VERB
admet-2756	256	99	in	in	ADP
admet-2756	256	100	physiological	physiological	ADJ
admet-2756	256	101	ph	ph	NOUN
admet-2756	256	102	as	as	ADV
admet-2756	256	103	well	well	ADV
admet-2756	256	104	[	[	X
admet-2756	256	105	30	30	NUM
admet-2756	256	106	]	]	PUNCT
admet-2756	256	107	inorganic	inorganic	ADJ
admet-2756	256	108	carbon	carbon	NOUN
admet-2756	256	109	-	-	PUNCT
admet-2756	256	110	based	base	VERB
admet-2756	256	111	systems	system	NOUN
admet-2756	256	112	(	(	PUNCT
admet-2756	256	113	gon	gon	PROPN
admet-2756	256	114	/	/	SYM
admet-2756	256	115	aln	aln	PROPN
admet-2756	256	116	/	/	SYM
admet-2756	256	117	dox	dox	NOUN
admet-2756	256	118	)	)	PUNCT
admet-2756	256	119	outstandingly	outstandingly	ADV
admet-2756	256	120	high	high	ADJ
admet-2756	256	121	loading	loading	NOUN
admet-2756	256	122	and	and	CCONJ
admet-2756	256	123	encapsulation	encapsulation	NOUN
admet-2756	256	124	efficiency	efficiency	NOUN
admet-2756	256	125	,	,	PUNCT
admet-2756	256	126	selective	selective	ADJ
admet-2756	256	127	accumulation	accumulation	NOUN
admet-2756	256	128	in	in	ADP
admet-2756	256	129	tumour	tumour	NOUN
admet-2756	256	130	-	-	PUNCT
admet-2756	256	131	bearing	bear	VERB
admet-2756	256	132	bone	bone	NOUN
admet-2756	256	133	,	,	PUNCT
admet-2756	256	134	high	high	ADJ
admet-2756	256	135	release	release	NOUN
admet-2756	256	136	sensitivity	sensitivity	NOUN
admet-2756	256	137	to	to	AUX
admet-2756	256	138	ph	ph	VERB
admet-2756	256	139	similar	similar	ADJ
admet-2756	256	140	in	in	ADP
admet-2756	256	141	vitro	vitro	X
admet-2756	256	142	cytotoxicity	cytotoxicity	NOUN
admet-2756	256	143	of	of	ADP
admet-2756	256	144	free	free	ADJ
admet-2756	256	145	dox	dox	NOUN
admet-2756	256	146	and	and	CCONJ
admet-2756	256	147	dox@gon	dox@gon	PROPN
admet-2756	256	148	-	-	PUNCT
admet-2756	256	149	aln	aln	PROPN
admet-2756	256	150	[	[	X
admet-2756	256	151	33	33	NUM
admet-2756	256	152	]	]	PUNCT
admet-2756	256	153	inorganic	inorganic	ADJ
admet-2756	256	154	carbon	carbon	NOUN
admet-2756	256	155	-	-	PUNCT
admet-2756	256	156	based	base	VERB
admet-2756	256	157	systems	system	NOUN
admet-2756	256	158	(	(	PUNCT
admet-2756	256	159	c60	c60	NOUN
admet-2756	256	160	/	/	SYM
admet-2756	256	161	ha	ha	ADJ
admet-2756	256	162	/	/	SYM
admet-2756	256	163	rgd	rgd	PROPN
admet-2756	256	164	/	/	SYM
admet-2756	256	165	aln	aln	PROPN
admet-2756	256	166	/	/	SYM
admet-2756	256	167	ce6	ce6	PROPN
admet-2756	256	168	)	)	PUNCT
admet-2756	256	169	capable	capable	ADJ
admet-2756	256	170	of	of	ADP
admet-2756	256	171	including	include	VERB
admet-2756	256	172	multiple	multiple	ADJ
admet-2756	256	173	ligands	ligand	NOUN
admet-2756	256	174	with	with	ADP
admet-2756	256	175	various	various	ADJ
admet-2756	256	176	functions	function	NOUN
admet-2756	256	177	,	,	PUNCT
admet-2756	256	178	significant	significant	ADJ
admet-2756	256	179	therapeutic	therapeutic	ADJ
admet-2756	256	180	results	result	NOUN
admet-2756	256	181	in	in	ADP
admet-2756	256	182	vivo	vivo	NOUN
admet-2756	256	183	and	and	CCONJ
admet-2756	256	184	tumour	tumour	NOUN
admet-2756	256	185	volume	volume	NOUN
admet-2756	256	186	reduction	reduction	NOUN
admet-2756	256	187	,	,	PUNCT
admet-2756	256	188	successful	successful	ADJ
admet-2756	256	189	circumvention	circumvention	NOUN
admet-2756	256	190	of	of	ADP
admet-2756	256	191	biocompatibility	biocompatibility	NOUN
admet-2756	256	192	concerns	concern	NOUN
admet-2756	256	193	of	of	ADP
admet-2756	256	194	cqds	cqds	NOUN
admet-2756	256	195	complex	complex	ADJ
admet-2756	256	196	preparation	preparation	NOUN
admet-2756	256	197	procedure	procedure	NOUN
admet-2756	256	198	due	due	ADP
admet-2756	256	199	to	to	ADP
admet-2756	256	200	the	the	DET
admet-2756	256	201	presence	presence	NOUN
admet-2756	256	202	of	of	ADP
admet-2756	256	203	multiple	multiple	ADJ
admet-2756	256	204	ligands	ligand	NOUN
admet-2756	256	205	[	[	X
admet-2756	256	206	36	36	NUM
admet-2756	256	207	]	]	X
admet-2756	256	208	dendrimer	dendrimer	NOUN
admet-2756	256	209	(	(	PUNCT
admet-2756	256	210	pamam	pamam	NOUN
admet-2756	256	211	/	/	SYM
admet-2756	256	212	ha	ha	PROPN
admet-2756	256	213	/	/	SYM
admet-2756	256	214	aln	aln	PROPN
admet-2756	256	215	/	/	SYM
admet-2756	256	216	dtx	dtx	PROPN
admet-2756	256	217	)	)	PUNCT
admet-2756	256	218	sequential	sequential	ADJ
admet-2756	256	219	targeting	targeting	NOUN
admet-2756	256	220	of	of	ADP
admet-2756	256	221	bone	bone	NOUN
admet-2756	256	222	mineral	mineral	NOUN
admet-2756	256	223	matrix	matrix	NOUN
admet-2756	256	224	and	and	CCONJ
admet-2756	256	225	cancerous	cancerous	ADJ
admet-2756	256	226	cell	cell	NOUN
admet-2756	256	227	receptor	receptor	NOUN
admet-2756	256	228	by	by	ADP
admet-2756	256	229	a	a	DET
admet-2756	256	230	single	single	ADJ
admet-2756	256	231	ligand	ligand	NOUN
admet-2756	256	232	using	use	VERB
admet-2756	256	233	a	a	DET
admet-2756	256	234	ph	ph	ADJ
admet-2756	256	235	-	-	ADJ
admet-2756	256	236	sensitive	sensitive	ADJ
admet-2756	256	237	linker	linker	NOUN
admet-2756	256	238	significant	significant	ADJ
admet-2756	256	239	burst	burst	ADJ
admet-2756	256	240	release	release	NOUN
admet-2756	256	241	is	be	AUX
admet-2756	256	242	anticipated	anticipate	VERB
admet-2756	256	243	in	in	ADP
admet-2756	256	244	vivo	vivo	NOUN
admet-2756	256	245	due	due	ADP
admet-2756	256	246	to	to	ADP
admet-2756	256	247	the	the	DET
admet-2756	256	248	parallel	parallel	ADJ
admet-2756	256	249	sensitivity	sensitivity	NOUN
admet-2756	256	250	of	of	ADP
admet-2756	256	251	nanostructure	nanostructure	NOUN
admet-2756	256	252	to	to	ADP
admet-2756	256	253	reducing	reduce	VERB
admet-2756	256	254	agents	agent	NOUN
admet-2756	256	255	and	and	CCONJ
admet-2756	256	256	ph	ph	ADJ
admet-2756	256	257	[	[	PUNCT
admet-2756	256	258	54	54	NUM
admet-2756	256	259	]	]	X
admet-2756	256	260	albumin	albumin	ADJ
admet-2756	256	261	np	np	PROPN
admet-2756	256	262	(	(	PUNCT
admet-2756	256	263	albumin	albumin	PROPN
admet-2756	256	264	/	/	SYM
admet-2756	256	265	aln	aln	PROPN
admet-2756	256	266	/	/	SYM
admet-2756	256	267	dox	dox	NOUN
admet-2756	256	268	)	)	PUNCT
admet-2756	256	269	size	size	NOUN
admet-2756	256	270	stability	stability	NOUN
admet-2756	256	271	in	in	ADP
admet-2756	256	272	fetal	fetal	ADJ
admet-2756	256	273	bovine	bovine	NOUN
admet-2756	256	274	serum	serum	NOUN
admet-2756	256	275	over	over	ADP
admet-2756	256	276	time	time	NOUN
admet-2756	256	277	,	,	PUNCT
admet-2756	256	278	selective	selective	ADJ
admet-2756	256	279	accumulation	accumulation	NOUN
admet-2756	256	280	in	in	ADP
admet-2756	256	281	tumourbearing	tumourbeare	VERB
admet-2756	256	282	bone	bone	NOUN
admet-2756	256	283	and	and	CCONJ
admet-2756	256	284	clearance	clearance	NOUN
admet-2756	256	285	from	from	ADP
admet-2756	256	286	other	other	ADJ
admet-2756	256	287	organs	organ	NOUN
admet-2756	256	288	,	,	PUNCT
admet-2756	256	289	tumour	tumour	NOUN
admet-2756	256	290	-	-	PUNCT
admet-2756	256	291	targeting	target	VERB
admet-2756	256	292	functionality	functionality	NOUN
admet-2756	256	293	of	of	ADP
admet-2756	256	294	albumin	albumin	NOUN
admet-2756	256	295	unsuccessful	unsuccessful	ADJ
admet-2756	256	296	in	in	ADP
admet-2756	256	297	decreasing	decrease	VERB
admet-2756	256	298	tumour	tumour	ADJ
admet-2756	256	299	volume	volume	NOUN
admet-2756	256	300	in	in	ADP
admet-2756	256	301	vivo	vivo	NOUN
admet-2756	256	302	[	[	X
admet-2756	256	303	55	55	NUM
admet-2756	256	304	]	]	X
admet-2756	256	305	self	self	NOUN
admet-2756	256	306	-	-	PUNCT
admet-2756	256	307	assembling	assemble	VERB
admet-2756	256	308	system	system	NOUN
admet-2756	256	309	(	(	PUNCT
admet-2756	256	310	peg	peg	NOUN
admet-2756	256	311	/	/	SYM
admet-2756	256	312	aln	aln	PROPN
admet-2756	256	313	/	/	SYM
admet-2756	256	314	ptx	ptx	NOUN
admet-2756	256	315	)	)	PUNCT
admet-2756	256	316	biological	biological	ADJ
admet-2756	256	317	half	half	ADJ
admet-2756	256	318	-	-	PUNCT
admet-2756	256	319	life	life	NOUN
admet-2756	256	320	improved	improve	VERB
admet-2756	256	321	4	4	NUM
admet-2756	256	322	-	-	NOUN
admet-2756	256	323	fold	fold	ADJ
admet-2756	256	324	compared	compare	VERB
admet-2756	256	325	with	with	ADP
admet-2756	256	326	free	free	ADJ
admet-2756	256	327	drug	drug	NOUN
admet-2756	256	328	significant	significant	ADJ
admet-2756	256	329	accumulation	accumulation	NOUN
admet-2756	256	330	in	in	ADP
admet-2756	256	331	the	the	DET
admet-2756	256	332	kidney	kidney	NOUN
admet-2756	256	333	due	due	ADP
admet-2756	256	334	to	to	ADP
admet-2756	256	335	renal	renal	ADJ
admet-2756	256	336	excretion	excretion	NOUN
admet-2756	257	1	[	[	X
admet-2756	257	2	56	56	NUM
admet-2756	257	3	]	]	X
admet-2756	257	4	self	self	NOUN
admet-2756	257	5	-	-	PUNCT
admet-2756	257	6	assembling	assemble	VERB
admet-2756	257	7	system	system	NOUN
admet-2756	257	8	(	(	PUNCT
admet-2756	257	9	dope	dope	NOUN
admet-2756	257	10	/	/	SYM
admet-2756	257	11	chems	chem	NOUN
admet-2756	257	12	/	/	SYM
admet-2756	257	13	dspe	dspe	PROPN
admet-2756	257	14	/	/	SYM
admet-2756	257	15	aln	aln	PROPN
admet-2756	257	16	/	/	SYM
admet-2756	257	17	dox	dox	NOUN
admet-2756	257	18	)	)	PUNCT
admet-2756	257	19	modifying	modify	VERB
admet-2756	257	20	nps	nps	PROPN
admet-2756	257	21	with	with	ADP
admet-2756	257	22	aln	aln	PROPN
admet-2756	257	23	reduced	reduce	VERB
admet-2756	257	24	nonspecific	nonspecific	ADJ
admet-2756	257	25	accumulation	accumulation	NOUN
admet-2756	257	26	in	in	ADP
admet-2756	257	27	the	the	DET
admet-2756	257	28	spleen	spleen	NOUN
admet-2756	257	29	and	and	CCONJ
admet-2756	257	30	liver	liver	NOUN
admet-2756	257	31	and	and	CCONJ
admet-2756	257	32	doubled	double	VERB
admet-2756	257	33	accumulation	accumulation	NOUN
admet-2756	257	34	in	in	ADP
admet-2756	257	35	the	the	DET
admet-2756	257	36	tumour	tumour	NOUN
admet-2756	257	37	increased	increase	VERB
admet-2756	257	38	accumulation	accumulation	NOUN
admet-2756	257	39	in	in	ADP
admet-2756	257	40	liver	liver	NOUN
admet-2756	257	41	and	and	CCONJ
admet-2756	257	42	spleen	spleen	NOUN
admet-2756	257	43	compared	compare	VERB
admet-2756	257	44	with	with	ADP
admet-2756	257	45	free	free	ADJ
admet-2756	257	46	dox	dox	NOUN
admet-2756	257	47	[	[	X
admet-2756	257	48	57	57	NUM
admet-2756	257	49	]	]	X
admet-2756	257	50	self	self	NOUN
admet-2756	257	51	-	-	PUNCT
admet-2756	257	52	assembling	assemble	VERB
admet-2756	257	53	system	system	NOUN
admet-2756	257	54	(	(	PUNCT
admet-2756	257	55	spc	spc	PROPN
admet-2756	257	56	/	/	SYM
admet-2756	257	57	cholesterol	cholesterol	PROPN
admet-2756	257	58	/	/	SYM
admet-2756	257	59	ha	ha	INTJ
admet-2756	257	60	/	/	SYM
admet-2756	257	61	aln	aln	PROPN
admet-2756	257	62	/	/	SYM
admet-2756	257	63	dox	dox	NOUN
admet-2756	257	64	)	)	PUNCT
admet-2756	257	65	sequential	sequential	ADJ
admet-2756	257	66	targeting	targeting	NOUN
admet-2756	257	67	of	of	ADP
admet-2756	257	68	bone	bone	NOUN
admet-2756	257	69	mineral	mineral	NOUN
admet-2756	257	70	matrix	matrix	NOUN
admet-2756	257	71	and	and	CCONJ
admet-2756	257	72	cancerous	cancerous	ADJ
admet-2756	257	73	cell	cell	NOUN
admet-2756	257	74	receptor	receptor	NOUN
admet-2756	257	75	by	by	ADP
admet-2756	257	76	a	a	DET
admet-2756	257	77	single	single	ADJ
admet-2756	257	78	ligand	ligand	NOUN
admet-2756	257	79	using	use	VERB
admet-2756	257	80	a	a	DET
admet-2756	257	81	redox	redox	ADJ
admet-2756	257	82	-	-	PUNCT
admet-2756	257	83	sensitive	sensitive	ADJ
admet-2756	257	84	linker	linker	NOUN
admet-2756	257	85	,	,	PUNCT
admet-2756	257	86	minimal	minimal	ADJ
admet-2756	257	87	systemic	systemic	ADJ
admet-2756	257	88	side	side	NOUN
admet-2756	257	89	effects	effect	NOUN
admet-2756	257	90	are	be	AUX
admet-2756	257	91	anticipated	anticipate	VERB
admet-2756	257	92	unsuccessful	unsuccessful	ADJ
admet-2756	257	93	in	in	ADP
admet-2756	257	94	decreasing	decrease	VERB
admet-2756	257	95	tumour	tumour	ADJ
admet-2756	257	96	volume	volume	NOUN
admet-2756	257	97	in	in	ADP
admet-2756	257	98	vivo	vivo	NOUN
admet-2756	257	99	[	[	X
admet-2756	258	1	44	44	NUM
admet-2756	258	2	]	]	SYM
admet-2756	258	3	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	PROPN
admet-2756	258	4	m.	m.	PROPN
admet-2756	258	5	eshaghi	eshaghi	PROPN
admet-2756	258	6	et	et	PROPN
admet-2756	258	7	al	al	PROPN
admet-2756	258	8	.	.	PROPN
admet-2756	258	9	admet	admet	PROPN
admet-2756	258	10	&	&	CCONJ
admet-2756	258	11	dmpk	dmpk	PROPN
admet-2756	258	12	13(3	13(3	NUM
admet-2756	258	13	)	)	PUNCT
admet-2756	258	14	(	(	PUNCT
admet-2756	258	15	2025	2025	NUM
admet-2756	258	16	)	)	PUNCT
admet-2756	258	17	2756	2756	NUM
admet-2756	258	18	12	12	NUM
admet-2756	258	19	drug	drug	NOUN
admet-2756	258	20	delivery	delivery	NOUN
admet-2756	258	21	system	system	NOUN
admet-2756	258	22	type	type	NOUN
admet-2756	258	23	distinguished	distinguished	ADJ
admet-2756	258	24	achievements	achievement	NOUN
admet-2756	258	25	unignorable	unignorable	ADJ
admet-2756	258	26	drawbacks	drawback	NOUN
admet-2756	258	27	ref	ref	NOUN
admet-2756	258	28	.	.	PUNCT
admet-2756	259	1	self	self	NOUN
admet-2756	259	2	-	-	PUNCT
admet-2756	259	3	assembling	assemble	VERB
admet-2756	259	4	system	system	NOUN
admet-2756	259	5	(	(	PUNCT
admet-2756	259	6	ha	ha	INTJ
admet-2756	259	7	/	/	SYM
admet-2756	259	8	c18	c18	PROPN
admet-2756	259	9	/	/	SYM
admet-2756	259	10	aln	aln	PROPN
admet-2756	259	11	/	/	SYM
admet-2756	259	12	cur	cur	PROPN
admet-2756	259	13	)	)	PUNCT
admet-2756	259	14	very	very	ADV
admet-2756	259	15	low	low	ADJ
admet-2756	259	16	cmc	cmc	NOUN
admet-2756	259	17	value	value	NOUN
admet-2756	259	18	and	and	CCONJ
admet-2756	259	19	consequently	consequently	ADV
admet-2756	259	20	high	high	ADJ
admet-2756	259	21	in	in	ADP
admet-2756	259	22	vivo	vivo	ADJ
admet-2756	259	23	stability	stability	NOUN
admet-2756	259	24	unsuccessful	unsuccessful	ADJ
admet-2756	259	25	in	in	ADP
admet-2756	259	26	decreasing	decrease	VERB
admet-2756	259	27	tumour	tumour	ADJ
admet-2756	259	28	volume	volume	NOUN
admet-2756	259	29	in	in	ADP
admet-2756	259	30	vivo	vivo	NOUN
admet-2756	259	31	[	[	X
admet-2756	259	32	45	45	NUM
admet-2756	259	33	]	]	PUNCT
admet-2756	259	34	self	self	NOUN
admet-2756	259	35	-	-	PUNCT
admet-2756	259	36	assembling	assemble	VERB
admet-2756	259	37	system	system	NOUN
admet-2756	259	38	(	(	PUNCT
admet-2756	259	39	dopa	dopa	NOUN
admet-2756	259	40	/	/	SYM
admet-2756	259	41	znpc	znpc	NOUN
admet-2756	259	42	/	/	SYM
admet-2756	259	43	aln	aln	PROPN
admet-2756	259	44	/	/	SYM
admet-2756	259	45	btz	btz	PROPN
admet-2756	259	46	)	)	PUNCT
admet-2756	259	47	successful	successful	ADJ
admet-2756	259	48	inhibition	inhibition	NOUN
admet-2756	259	49	of	of	ADP
admet-2756	259	50	tumour	tumour	ADJ
admet-2756	259	51	growth	growth	NOUN
admet-2756	259	52	in	in	ADP
admet-2756	259	53	vivo	vivo	ADJ
admet-2756	259	54	unsuccessful	unsuccessful	ADJ
admet-2756	259	55	in	in	ADP
admet-2756	259	56	decreasing	decrease	VERB
admet-2756	259	57	tumour	tumour	NOUN
admet-2756	259	58	volume	volume	NOUN
admet-2756	259	59	in	in	ADP
admet-2756	259	60	vivo	vivo	NOUN
admet-2756	259	61	[	[	X
admet-2756	259	62	47	47	NUM
admet-2756	259	63	]	]	PUNCT
admet-2756	259	64	multimodal	multimodal	NOUN
admet-2756	259	65	system	system	NOUN
admet-2756	259	66	(	(	PUNCT
admet-2756	259	67	batio3	batio3	NOUN
admet-2756	259	68	/	/	SYM
admet-2756	259	69	fe3o4	fe3o4	PROPN
admet-2756	259	70	/	/	SYM
admet-2756	259	71	ris	ris	PROPN
admet-2756	259	72	)	)	PUNCT
admet-2756	259	73	engineered	engineer	VERB
admet-2756	259	74	to	to	PART
admet-2756	259	75	execute	execute	VERB
admet-2756	259	76	various	various	ADJ
admet-2756	259	77	modes	mode	NOUN
admet-2756	259	78	of	of	ADP
admet-2756	259	79	cancer	cancer	NOUN
admet-2756	259	80	therapy	therapy	NOUN
admet-2756	259	81	complex	complex	ADJ
admet-2756	259	82	synthesis	synthesis	NOUN
admet-2756	259	83	protocol	protocol	NOUN
admet-2756	259	84	[	[	X
admet-2756	259	85	58	58	NUM
admet-2756	259	86	]	]	PUNCT
admet-2756	259	87	metal	metal	NOUN
admet-2756	259	88	-	-	PUNCT
admet-2756	259	89	organic	organic	ADJ
admet-2756	259	90	frameworks	framework	NOUN
admet-2756	259	91	(	(	PUNCT
admet-2756	259	92	zif8	zif8	PROPN
admet-2756	259	93	/	/	SYM
admet-2756	259	94	zol	zol	VERB
admet-2756	259	95	)	)	PUNCT
admet-2756	259	96	simple	simple	ADJ
admet-2756	259	97	synthesis	synthesis	NOUN
admet-2756	259	98	protocol	protocol	NOUN
admet-2756	259	99	with	with	ADP
admet-2756	259	100	mild	mild	ADJ
admet-2756	259	101	conditions	condition	NOUN
admet-2756	259	102	enabling	enable	VERB
admet-2756	259	103	delivery	delivery	NOUN
admet-2756	259	104	of	of	ADP
admet-2756	259	105	sensitive	sensitive	ADJ
admet-2756	259	106	biological	biological	ADJ
admet-2756	259	107	molecules	molecule	NOUN
admet-2756	259	108	high	high	ADJ
admet-2756	259	109	burst	burst	ADJ
admet-2756	259	110	release	release	NOUN
admet-2756	259	111	associated	associate	VERB
admet-2756	259	112	with	with	ADP
admet-2756	259	113	the	the	DET
admet-2756	259	114	ph	ph	ADJ
admet-2756	259	115	-	-	ADJ
admet-2756	259	116	sensitive	sensitive	ADJ
admet-2756	259	117	nature	nature	NOUN
admet-2756	259	118	of	of	ADP
admet-2756	259	119	the	the	DET
admet-2756	259	120	zif-8	zif-8	NUM
admet-2756	259	121	structure	structure	NOUN
admet-2756	259	122	[	[	X
admet-2756	259	123	59	59	NUM
admet-2756	259	124	]	]	PUNCT
admet-2756	259	125	plga	plga	NOUN
admet-2756	259	126	np	np	INTJ
admet-2756	259	127	(	(	PUNCT
admet-2756	259	128	plga	plga	PROPN
admet-2756	259	129	/	/	SYM
admet-2756	259	130	aln	aln	PROPN
admet-2756	259	131	/	/	SYM
admet-2756	259	132	zol	zol	PROPN
admet-2756	259	133	/	/	SYM
admet-2756	259	134	epb	epb	PROPN
admet-2756	259	135	/	/	SYM
admet-2756	259	136	gcb	gcb	PROPN
admet-2756	259	137	/	/	SYM
admet-2756	259	138	dox/	dox/	PROPN
admet-2756	259	139	cxb	cxb	NOUN
admet-2756	259	140	)	)	PUNCT
admet-2756	259	141	high	high	ADJ
admet-2756	259	142	loading	loading	NOUN
admet-2756	259	143	efficiency	efficiency	NOUN
admet-2756	259	144	,	,	PUNCT
admet-2756	259	145	preservation	preservation	NOUN
admet-2756	259	146	of	of	ADP
admet-2756	259	147	drug	drug	NOUN
admet-2756	259	148	molecules	molecule	NOUN
admet-2756	259	149	from	from	ADP
admet-2756	259	150	intracellular	intracellular	ADJ
admet-2756	259	151	degradation	degradation	NOUN
admet-2756	259	152	,	,	PUNCT
admet-2756	259	153	prevention	prevention	NOUN
admet-2756	259	154	of	of	ADP
admet-2756	259	155	quick	quick	ADJ
admet-2756	259	156	efflux	efflux	NOUN
admet-2756	259	157	,	,	PUNCT
admet-2756	259	158	inhibition	inhibition	NOUN
admet-2756	259	159	of	of	ADP
admet-2756	259	160	burst	burst	ADJ
admet-2756	259	161	release	release	NOUN
admet-2756	259	162	by	by	ADP
admet-2756	259	163	the	the	DET
admet-2756	259	164	nanocarrier	nanocarrier	NOUN
admet-2756	259	165	even	even	ADV
admet-2756	259	166	under	under	ADP
admet-2756	259	167	acidic	acidic	ADJ
admet-2756	259	168	conditions	condition	NOUN
admet-2756	259	169	,	,	PUNCT
admet-2756	259	170	promising	promise	VERB
admet-2756	259	171	therapeutic	therapeutic	ADJ
admet-2756	259	172	results	result	NOUN
admet-2756	259	173	in	in	ADP
admet-2756	259	174	vivo	vivo	NOUN
admet-2756	259	175	and	and	CCONJ
admet-2756	259	176	reduced	reduce	VERB
admet-2756	259	177	tumour	tumour	NOUN
admet-2756	259	178	volume	volume	NOUN
admet-2756	259	179	[	[	X
admet-2756	259	180	51	51	NUM
admet-2756	259	181	-	-	SYM
admet-2756	259	182	53	53	NUM
admet-2756	259	183	]	]	PUNCT
admet-2756	259	184	self	self	NOUN
admet-2756	259	185	-	-	PUNCT
admet-2756	259	186	assembling	assemble	VERB
admet-2756	259	187	system	system	NOUN
admet-2756	259	188	(	(	PUNCT
admet-2756	259	189	pip	pip	NOUN
admet-2756	259	190	-	-	PUNCT
admet-2756	259	191	bp	bp	PROPN
admet-2756	259	192	ionizable	ionizable	PROPN
admet-2756	259	193	lipids	lipids	PROPN
admet-2756	259	194	)	)	PUNCT
admet-2756	259	195	an	an	DET
admet-2756	259	196	extensive	extensive	ADJ
admet-2756	259	197	library	library	NOUN
admet-2756	259	198	of	of	ADP
admet-2756	259	199	piperazine	piperazine	NOUN
admet-2756	259	200	-	-	PUNCT
admet-2756	259	201	based	base	VERB
admet-2756	259	202	bisphosphonate	bisphosphonate	NOUN
admet-2756	259	203	ionizable	ionizable	ADJ
admet-2756	259	204	lipids	lipid	NOUN
admet-2756	259	205	were	be	AUX
admet-2756	259	206	prepared	prepare	VERB
admet-2756	259	207	which	which	PRON
admet-2756	259	208	enabled	enable	VERB
admet-2756	259	209	targeted	target	VERB
admet-2756	259	210	delivery	delivery	NOUN
admet-2756	259	211	to	to	ADP
admet-2756	259	212	the	the	DET
admet-2756	259	213	bone	bone	NOUN
admet-2756	259	214	microenvironment	microenvironment	NOUN
admet-2756	259	215	in	in	ADP
admet-2756	259	216	vivo	vivo	NOUN
admet-2756	259	217	following	follow	VERB
admet-2756	259	218	systemic	systemic	ADJ
admet-2756	259	219	administration	administration	NOUN
admet-2756	259	220	the	the	DET
admet-2756	259	221	ring	ring	NOUN
admet-2756	259	222	structure	structure	NOUN
admet-2756	259	223	formed	form	VERB
admet-2756	259	224	through	through	ADP
admet-2756	259	225	cyclization	cyclization	NOUN
admet-2756	259	226	may	may	AUX
admet-2756	259	227	result	result	VERB
admet-2756	259	228	in	in	ADP
admet-2756	259	229	the	the	DET
admet-2756	259	230	random	random	ADJ
admet-2756	259	231	orientation	orientation	NOUN
admet-2756	259	232	of	of	ADP
admet-2756	259	233	the	the	DET
admet-2756	259	234	bisphosphonate	bisphosphonate	NOUN
admet-2756	259	235	group	group	NOUN
admet-2756	259	236	on	on	ADP
admet-2756	259	237	the	the	DET
admet-2756	259	238	surface	surface	NOUN
admet-2756	259	239	of	of	ADP
admet-2756	259	240	nanoparticles	nanoparticle	NOUN
admet-2756	259	241	either	either	CCONJ
admet-2756	259	242	outward	outward	ADV
admet-2756	259	243	or	or	CCONJ
admet-2756	259	244	inward	inward	ADV
admet-2756	260	1	[	[	X
admet-2756	260	2	60	60	NUM
admet-2756	260	3	]	]	SYM
admet-2756	260	4	bp	bp	PROPN
admet-2756	260	5	-	-	PUNCT
admet-2756	260	6	drug	drug	NOUN
admet-2756	260	7	conjugate	conjugate	NOUN
admet-2756	260	8	(	(	PUNCT
admet-2756	260	9	cy5.5	cy5.5	NOUN
admet-2756	260	10	-	-	NOUN
admet-2756	260	11	aln	aln	NOUN
admet-2756	260	12	)	)	PUNCT
admet-2756	260	13	in	in	ADP
admet-2756	260	14	vitro	vitro	X
admet-2756	260	15	and	and	CCONJ
admet-2756	260	16	in	in	ADP
admet-2756	260	17	vivo	vivo	ADJ
admet-2756	260	18	studies	study	NOUN
admet-2756	260	19	demonstrated	demonstrate	VERB
admet-2756	260	20	that	that	SCONJ
admet-2756	260	21	cy5.5	cy5.5	ADJ
admet-2756	260	22	-	-	ADJ
admet-2756	260	23	aln	aln	ADJ
admet-2756	260	24	targets	target	NOUN
admet-2756	260	25	mineralized	mineralize	VERB
admet-2756	260	26	components	component	NOUN
admet-2756	260	27	of	of	ADP
admet-2756	260	28	bone	bone	NOUN
admet-2756	260	29	-	-	PUNCT
admet-2756	260	30	forming	form	VERB
admet-2756	260	31	tumours	tumours	NOUN
admet-2756	260	32	no	no	DET
admet-2756	260	33	report	report	NOUN
admet-2756	260	34	of	of	ADP
admet-2756	260	35	therapeutic	therapeutic	ADJ
admet-2756	260	36	efficiency	efficiency	NOUN
admet-2756	260	37	evaluation	evaluation	NOUN
admet-2756	260	38	with	with	ADP
admet-2756	260	39	a	a	DET
admet-2756	260	40	small	small	ADJ
admet-2756	260	41	molecule	molecule	NOUN
admet-2756	260	42	drug	drug	NOUN
admet-2756	260	43	[	[	X
admet-2756	260	44	61	61	NUM
admet-2756	260	45	]	]	SYM
admet-2756	260	46	bp	bp	PROPN
admet-2756	260	47	-	-	PUNCT
admet-2756	260	48	drug	drug	NOUN
admet-2756	260	49	conjugate	conjugate	NOUN
admet-2756	260	50	(	(	PUNCT
admet-2756	260	51	)	)	PUNCT
admet-2756	260	52	the	the	DET
admet-2756	260	53	reactivity	reactivity	NOUN
admet-2756	260	54	of	of	ADP
admet-2756	260	55	the	the	DET
admet-2756	260	56	complexes	complex	NOUN
admet-2756	260	57	with	with	ADP
admet-2756	260	58	5'gmp	5'gmp	NUM
admet-2756	260	59	,	,	PUNCT
admet-2756	260	60	band	band	NOUN
admet-2756	260	61	g	g	NOUN
admet-2756	260	62	-	-	PUNCT
admet-2756	260	63	quadruplex	quadruplex	NOUN
admet-2756	260	64	dna	dna	NOUN
admet-2756	260	65	models	model	NOUN
admet-2756	260	66	,	,	PUNCT
admet-2756	260	67	and	and	CCONJ
admet-2756	260	68	their	their	PRON
admet-2756	260	69	cytotoxicity	cytotoxicity	NOUN
admet-2756	260	70	against	against	ADP
admet-2756	260	71	a	a	DET
admet-2756	260	72	panel	panel	NOUN
admet-2756	260	73	of	of	ADP
admet-2756	260	74	human	human	ADJ
admet-2756	260	75	tumour	tumour	NOUN
admet-2756	260	76	cell	cell	NOUN
admet-2756	260	77	lines	line	NOUN
admet-2756	260	78	was	be	AUX
admet-2756	260	79	explored	explore	VERB
admet-2756	260	80	no	no	PRON
admet-2756	260	81	in	in	ADP
admet-2756	260	82	vivo	vivo	ADJ
admet-2756	260	83	experiments	experiment	NOUN
admet-2756	260	84	were	be	AUX
admet-2756	260	85	reported	report	VERB
admet-2756	260	86	[	[	X
admet-2756	260	87	62	62	NUM
admet-2756	260	88	]	]	PUNCT
admet-2756	260	89	pamam	pamam	NOUN
admet-2756	260	90	:	:	PUNCT
admet-2756	260	91	polyamidoamine	polyamidoamine	NOUN
admet-2756	260	92	;	;	PUNCT
admet-2756	260	93	dtx	dtx	PROPN
admet-2756	260	94	:	:	PUNCT
admet-2756	260	95	docetaxel	docetaxel	PROPN
admet-2756	260	96	;	;	PUNCT
admet-2756	260	97	ptx	ptx	NOUN
admet-2756	260	98	:	:	PUNCT
admet-2756	260	99	paclitaxel	paclitaxel	PROPN
admet-2756	260	100	;	;	PUNCT
admet-2756	260	101	dope	dope	NOUN
admet-2756	260	102	:	:	PUNCT
admet-2756	260	103	cholesteryl	cholesteryl	PROPN
admet-2756	260	104	hemisuccinate	hemisuccinate	NOUN
admet-2756	260	105	;	;	PUNCT
admet-2756	260	106	chems	chem	NOUN
admet-2756	260	107	:	:	PUNCT
admet-2756	260	108	dioleoyl	dioleoyl	PROPN
admet-2756	260	109	phosphatidylethanolamine	phosphatidylethanolamine	PROPN
admet-2756	260	110	;	;	PUNCT
admet-2756	260	111	dspe	dspe	VERB
admet-2756	260	112	:	:	PUNCT
admet-2756	260	113	1,2	1,2	NUM
admet-2756	260	114	-	-	PUNCT
admet-2756	260	115	distearoyl	distearoyl	NOUN
admet-2756	260	116	-	-	PUNCT
admet-2756	260	117	sn	sn	NOUN
admet-2756	260	118	-	-	PUNCT
admet-2756	260	119	glycero-3phosphoethanolamine	glycero-3phosphoethanolamine	NOUN
admet-2756	260	120	;	;	PUNCT
admet-2756	260	121	spc	spc	PROPN
admet-2756	260	122	:	:	PUNCT
admet-2756	260	123	soybean	soybean	NOUN
admet-2756	260	124	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2756	260	125	;	;	PUNCT
admet-2756	260	126	c18	c18	NOUN
admet-2756	260	127	:	:	PUNCT
admet-2756	260	128	octadecanoic	octadecanoic	ADJ
admet-2756	260	129	acid	acid	NOUN
admet-2756	260	130	;	;	PUNCT
admet-2756	260	131	dopa	dopa	NOUN
admet-2756	260	132	:	:	PUNCT
admet-2756	260	133	dioleoyl	dioleoyl	ADJ
admet-2756	260	134	phosphatidic	phosphatidic	ADJ
admet-2756	260	135	acid	acid	NOUN
admet-2756	260	136	;	;	PUNCT
admet-2756	260	137	ris	ris	PROPN
admet-2756	260	138	:	:	PUNCT
admet-2756	260	139	risedronate	risedronate	VERB
admet-2756	260	140	;	;	PUNCT
admet-2756	260	141	zif-8	zif-8	NUM
admet-2756	260	142	:	:	PUNCT
admet-2756	260	143	a	a	DET
admet-2756	260	144	metal	metal	NOUN
admet-2756	260	145	-	-	PUNCT
admet-2756	260	146	organic	organic	ADJ
admet-2756	260	147	framework	framework	NOUN
admet-2756	260	148	composed	compose	VERB
admet-2756	260	149	of	of	ADP
admet-2756	260	150	zn2	zn2	PROPN
admet-2756	260	151	+	+	PROPN
admet-2756	260	152	ions	ion	NOUN
admet-2756	260	153	and	and	CCONJ
admet-2756	260	154	imidazolate	imidazolate	NOUN
admet-2756	260	155	ligands	ligand	NOUN
admet-2756	260	156	conclusion	conclusion	NOUN
admet-2756	260	157	bps	bps	NOUN
admet-2756	260	158	were	be	AUX
admet-2756	260	159	first	first	ADV
admet-2756	260	160	introduced	introduce	VERB
admet-2756	260	161	as	as	ADP
admet-2756	260	162	anti	anti	ADJ
admet-2756	260	163	-	-	ADJ
admet-2756	260	164	osteoporotic	osteoporotic	ADJ
admet-2756	260	165	agents	agent	NOUN
admet-2756	260	166	approximately	approximately	ADV
admet-2756	260	167	40	40	NUM
admet-2756	260	168	years	year	NOUN
admet-2756	260	169	ago	ago	ADV
admet-2756	260	170	.	.	PUNCT
admet-2756	261	1	over	over	ADP
admet-2756	261	2	the	the	DET
admet-2756	261	3	past	past	ADJ
admet-2756	261	4	decade	decade	NOUN
admet-2756	261	5	,	,	PUNCT
admet-2756	261	6	they	they	PRON
admet-2756	261	7	have	have	AUX
admet-2756	261	8	been	be	AUX
admet-2756	261	9	successfully	successfully	ADV
admet-2756	261	10	employed	employ	VERB
admet-2756	261	11	as	as	ADP
admet-2756	261	12	bone	bone	NOUN
admet-2756	261	13	-	-	PUNCT
admet-2756	261	14	targeting	target	VERB
admet-2756	261	15	molecules	molecule	NOUN
admet-2756	261	16	in	in	ADP
admet-2756	261	17	the	the	DET
admet-2756	261	18	design	design	NOUN
admet-2756	261	19	of	of	ADP
admet-2756	261	20	drug	drug	NOUN
admet-2756	261	21	delivery	delivery	NOUN
admet-2756	261	22	systems	system	NOUN
admet-2756	261	23	.	.	PUNCT
admet-2756	262	1	this	this	DET
admet-2756	262	2	review	review	NOUN
admet-2756	262	3	summarizes	summarize	VERB
admet-2756	262	4	recent	recent	ADJ
admet-2756	262	5	advancements	advancement	NOUN
admet-2756	262	6	in	in	ADP
admet-2756	262	7	utilizing	utilize	VERB
admet-2756	262	8	bps	bps	NOUN
admet-2756	262	9	to	to	PART
admet-2756	262	10	develop	develop	VERB
admet-2756	262	11	drug	drug	NOUN
admet-2756	262	12	delivery	delivery	NOUN
admet-2756	262	13	systems	system	NOUN
admet-2756	262	14	for	for	ADP
admet-2756	262	15	treating	treat	VERB
admet-2756	262	16	bone	bone	NOUN
admet-2756	262	17	-	-	PUNCT
admet-2756	262	18	associated	associate	VERB
admet-2756	262	19	cancers	cancer	NOUN
admet-2756	262	20	.	.	PUNCT
admet-2756	263	1	regardless	regardless	ADV
admet-2756	263	2	of	of	ADP
admet-2756	263	3	various	various	ADJ
admet-2756	263	4	types	type	NOUN
admet-2756	263	5	of	of	ADP
admet-2756	263	6	preparation	preparation	NOUN
admet-2756	263	7	methods	method	NOUN
admet-2756	263	8	,	,	PUNCT
admet-2756	263	9	including	include	VERB
admet-2756	263	10	conjugates	conjugate	NOUN
admet-2756	263	11	of	of	ADP
admet-2756	263	12	bps	bps	NOUN
admet-2756	263	13	to	to	ADP
admet-2756	263	14	different	different	ADJ
admet-2756	263	15	drug	drug	NOUN
admet-2756	263	16	molecules	molecule	NOUN
admet-2756	263	17	,	,	PUNCT
admet-2756	263	18	ca	ca	NOUN
admet-2756	263	19	or	or	CCONJ
admet-2756	263	20	carbon	carbon	NOUN
admet-2756	263	21	-	-	PUNCT
admet-2756	263	22	based	base	VERB
admet-2756	263	23	systems	system	NOUN
admet-2756	263	24	,	,	PUNCT
admet-2756	263	25	self	self	NOUN
admet-2756	263	26	-	-	PUNCT
admet-2756	263	27	assembling	assemble	VERB
admet-2756	263	28	micelles	micelle	NOUN
admet-2756	263	29	or	or	CCONJ
admet-2756	263	30	liposomes	liposome	NOUN
admet-2756	263	31	,	,	PUNCT
admet-2756	263	32	metal	metal	NOUN
admet-2756	263	33	-	-	PUNCT
admet-2756	263	34	organic	organic	ADJ
admet-2756	263	35	frameworks	framework	NOUN
admet-2756	263	36	,	,	PUNCT
admet-2756	263	37	and	and	CCONJ
admet-2756	263	38	plga	plga	VERB
admet-2756	263	39	nanoparticles	nanoparticle	NOUN
admet-2756	263	40	,	,	PUNCT
admet-2756	263	41	the	the	DET
admet-2756	263	42	evidence	evidence	NOUN
admet-2756	263	43	demonstrates	demonstrate	VERB
admet-2756	263	44	that	that	SCONJ
admet-2756	263	45	bp	bp	PROPN
admet-2756	263	46	-	-	PUNCT
admet-2756	263	47	based	base	VERB
admet-2756	263	48	drug	drug	NOUN
admet-2756	263	49	delivery	delivery	NOUN
admet-2756	263	50	systems	system	NOUN
admet-2756	263	51	hold	hold	VERB
admet-2756	263	52	significant	significant	ADJ
admet-2756	263	53	promise	promise	NOUN
admet-2756	263	54	,	,	PUNCT
admet-2756	263	55	particularly	particularly	ADV
admet-2756	263	56	for	for	ADP
admet-2756	263	57	the	the	DET
admet-2756	263	58	effective	effective	ADJ
admet-2756	263	59	treatment	treatment	NOUN
admet-2756	263	60	of	of	ADP
admet-2756	263	61	osteosarcoma	osteosarcoma	NOUN
admet-2756	263	62	.	.	PUNCT
admet-2756	264	1	despite	despite	SCONJ
admet-2756	264	2	the	the	DET
admet-2756	264	3	known	know	VERB
admet-2756	264	4	side	side	NOUN
admet-2756	264	5	effects	effect	NOUN
admet-2756	264	6	of	of	ADP
admet-2756	264	7	bps	bps	NOUN
admet-2756	264	8	,	,	PUNCT
admet-2756	264	9	their	their	PRON
admet-2756	264	10	integration	integration	NOUN
admet-2756	264	11	with	with	ADP
admet-2756	264	12	conventional	conventional	ADJ
admet-2756	264	13	therapies	therapy	NOUN
admet-2756	264	14	offers	offer	VERB
admet-2756	264	15	enhanced	enhance	VERB
admet-2756	264	16	targeting	targeting	NOUN
admet-2756	264	17	and	and	CCONJ
admet-2756	264	18	cytotoxicity	cytotoxicity	NOUN
admet-2756	264	19	against	against	ADP
admet-2756	264	20	bone	bone	NOUN
admet-2756	264	21	cancer	cancer	NOUN
admet-2756	264	22	cells	cell	NOUN
admet-2756	264	23	,	,	PUNCT
admet-2756	264	24	presenting	present	VERB
admet-2756	264	25	a	a	DET
admet-2756	264	26	high	high	ADJ
admet-2756	264	27	potential	potential	NOUN
admet-2756	264	28	for	for	ADP
admet-2756	264	29	synergistic	synergistic	ADJ
admet-2756	264	30	effects	effect	NOUN
admet-2756	264	31	that	that	PRON
admet-2756	264	32	could	could	AUX
admet-2756	264	33	improve	improve	VERB
admet-2756	264	34	therapeutic	therapeutic	ADJ
admet-2756	264	35	outcomes	outcome	NOUN
admet-2756	264	36	for	for	ADP
admet-2756	264	37	many	many	ADJ
admet-2756	264	38	treatments	treatment	NOUN
admet-2756	264	39	.	.	PUNCT
admet-2756	265	1	funding	funding	NOUN
admet-2756	265	2	:	:	PUNCT
admet-2756	265	3	no	no	DET
admet-2756	265	4	conflict	conflict	NOUN
admet-2756	265	5	of	of	ADP
admet-2756	265	6	interest	interest	NOUN
admet-2756	265	7	:	:	PUNCT
admet-2756	265	8	the	the	DET
admet-2756	265	9	authors	author	NOUN
admet-2756	265	10	declare	declare	VERB
admet-2756	265	11	that	that	SCONJ
admet-2756	265	12	they	they	PRON
admet-2756	265	13	have	have	VERB
admet-2756	265	14	no	no	DET
admet-2756	265	15	known	know	VERB
admet-2756	265	16	competing	compete	VERB
admet-2756	265	17	financial	financial	ADJ
admet-2756	265	18	interests	interest	NOUN
admet-2756	265	19	or	or	CCONJ
admet-2756	265	20	personal	personal	ADJ
admet-2756	265	21	relationships	relationship	NOUN
admet-2756	265	22	that	that	PRON
admet-2756	265	23	could	could	AUX
admet-2756	265	24	have	have	AUX
admet-2756	265	25	appeared	appear	VERB
admet-2756	265	26	to	to	PART
admet-2756	265	27	influence	influence	VERB
admet-2756	265	28	the	the	DET
admet-2756	265	29	work	work	NOUN
admet-2756	265	30	reported	report	VERB
admet-2756	265	31	in	in	ADP
admet-2756	265	32	this	this	DET
admet-2756	265	33	paper	paper	NOUN
admet-2756	265	34	.	.	PUNCT
admet-2756	266	1	author	author	NOUN
admet-2756	266	2	contributions	contribution	NOUN
admet-2756	266	3	:	:	PUNCT
admet-2756	266	4	mohammadmahdi	mohammadmahdi	PROPN
admet-2756	266	5	eshaghi	eshaghi	PROPN
admet-2756	266	6	conceptualization	conceptualization	NOUN
admet-2756	266	7	,	,	PUNCT
admet-2756	266	8	data	data	NOUN
admet-2756	266	9	curation	curation	NOUN
admet-2756	266	10	,	,	PUNCT
admet-2756	266	11	writing	write	VERB
admet-2756	266	12	original	original	ADJ
admet-2756	266	13	draft	draft	NOUN
admet-2756	266	14	;	;	PUNCT
admet-2756	266	15	fariba	fariba	NOUN
admet-2756	266	16	ganji	ganji	NOUN
admet-2756	266	17	conceptualization	conceptualization	NOUN
admet-2756	266	18	,	,	PUNCT
admet-2756	266	19	supervision	supervision	NOUN
admet-2756	266	20	,	,	PUNCT
admet-2756	266	21	methodology	methodology	NOUN
admet-2756	266	22	,	,	PUNCT
admet-2756	266	23	writing	writing	NOUN
admet-2756	266	24	,	,	PUNCT
admet-2756	266	25	review	review	NOUN
admet-2756	266	26	and	and	CCONJ
admet-2756	266	27	editing	editing	NOUN
admet-2756	266	28	;	;	PUNCT
admet-2756	266	29	hossein	hossein	PROPN
admet-2756	266	30	shaki	shaki	PROPN
admet-2756	266	31	supervision	supervision	PROPN
admet-2756	266	32	,	,	PUNCT
admet-2756	266	33	writing	writing	NOUN
admet-2756	266	34	,	,	PUNCT
admet-2756	266	35	review	review	NOUN
admet-2756	266	36	and	and	CCONJ
admet-2756	266	37	editing	editing	NOUN
admet-2756	266	38	;	;	PUNCT
admet-2756	266	39	lobat	lobat	NOUN
admet-2756	266	40	tayebi	tayebi	PROPN
admet-2756	266	41	supervision	supervision	NOUN
admet-2756	266	42	,	,	PUNCT
admet-2756	266	43	writing	writing	NOUN
admet-2756	266	44	,	,	PUNCT
admet-2756	266	45	review	review	NOUN
admet-2756	266	46	and	and	CCONJ
admet-2756	266	47	editing	editing	NOUN
admet-2756	266	48	.	.	PUNCT
admet-2756	267	1	admet	admet	PROPN
admet-2756	267	2	&	&	CCONJ
admet-2756	267	3	dmpk	dmpk	PROPN
admet-2756	267	4	13(3	13(3	NUM
admet-2756	267	5	)	)	PUNCT
admet-2756	267	6	(	(	PUNCT
admet-2756	267	7	2025	2025	NUM
admet-2756	267	8	)	)	PUNCT
admet-2756	267	9	2756	2756	NUM
admet-2756	267	10	bisphosphonates	bisphosphonate	NOUN
admet-2756	267	11	for	for	ADP
admet-2756	267	12	bone	bone	NOUN
admet-2756	267	13	cancer	cancer	NOUN
admet-2756	267	14	therapy	therapy	NOUN
admet-2756	267	15	doi	doi	NOUN
admet-2756	267	16	:	:	PUNCT
admet-2756	267	17	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	ADJ
admet-2756	267	18	13	13	NUM
admet-2756	267	19	consent	consent	NOUN
admet-2756	267	20	to	to	PART
admet-2756	267	21	publish	publish	VERB
admet-2756	267	22	:	:	PUNCT
admet-2756	267	23	the	the	DET
admet-2756	267	24	authors	author	NOUN
admet-2756	267	25	confirm	confirm	VERB
admet-2756	267	26	that	that	SCONJ
admet-2756	267	27	this	this	DET
admet-2756	267	28	paper	paper	NOUN
admet-2756	267	29	does	do	AUX
admet-2756	267	30	not	not	PART
admet-2756	267	31	include	include	VERB
admet-2756	267	32	any	any	DET
admet-2756	267	33	data	datum	NOUN
admet-2756	267	34	which	which	PRON
admet-2756	267	35	would	would	AUX
admet-2756	267	36	require	require	VERB
admet-2756	267	37	obtaining	obtain	VERB
admet-2756	267	38	publication	publication	NOUN
admet-2756	267	39	consent	consent	NOUN
admet-2756	267	40	from	from	ADP
admet-2756	267	41	any	any	DET
admet-2756	267	42	individuals	individual	NOUN
admet-2756	267	43	.	.	PUNCT
admet-2756	268	1	references	reference	NOUN
admet-2756	268	2	[	[	X
admet-2756	268	3	1	1	NUM
admet-2756	268	4	]	]	PUNCT
admet-2756	268	5	m.	m.	NOUN
admet-2756	268	6	chauhan	chauhan	PROPN
admet-2756	268	7	,	,	PUNCT
admet-2756	268	8	s.	s.	PROPN
admet-2756	268	9	sun	sun	PROPN
admet-2756	268	10	,	,	PUNCT
admet-2756	268	11	j.	j.	PROPN
admet-2756	268	12	tao	tao	PROPN
admet-2756	268	13	,	,	PUNCT
admet-2756	268	14	p.p	p.p	PROPN
admet-2756	268	15	.	.	PROPN
admet-2756	268	16	sadeghizadeh	sadeghizadeh	PROPN
admet-2756	268	17	,	,	PUNCT
admet-2756	268	18	p.	p.	NOUN
admet-2756	268	19	cherian	cherian	PROPN
admet-2756	268	20	,	,	PUNCT
admet-2756	268	21	a.f	a.f	PROPN
admet-2756	268	22	.	.	PROPN
admet-2756	268	23	junka	junka	PROPN
admet-2756	268	24	,	,	PUNCT
admet-2756	268	25	e.	e.	PROPN
admet-2756	268	26	sodagar	sodagar	PROPN
admet-2756	268	27	,	,	PUNCT
admet-2756	268	28	l.	l.	PROPN
admet-2756	268	29	xing	xing	PROPN
admet-2756	268	30	,	,	PUNCT
admet-2756	268	31	r.k	r.k	PROPN
admet-2756	268	32	.	.	PROPN
admet-2756	268	33	boeckman	boeckman	PROPN
admet-2756	268	34	jr	jr	PROPN
admet-2756	268	35	,	,	PUNCT
admet-2756	268	36	v.	v.	PROPN
admet-2756	268	37	srinivasan	srinivasan	NOUN
admet-2756	268	38	,	,	PUNCT
admet-2756	268	39	z.	z.	PROPN
admet-2756	268	40	yao	yao	PROPN
admet-2756	268	41	,	,	PUNCT
admet-2756	268	42	b.f	b.f	PROPN
admet-2756	268	43	.	.	PROPN
admet-2756	268	44	boyce	boyce	PROPN
admet-2756	268	45	.	.	PUNCT
admet-2756	269	1	bisphosphonates	bisphosphonate	NOUN
admet-2756	269	2	for	for	ADP
admet-2756	269	3	delivering	deliver	VERB
admet-2756	269	4	drugs	drug	NOUN
admet-2756	269	5	to	to	ADP
admet-2756	269	6	bone	bone	NOUN
admet-2756	269	7	.	.	PUNCT
admet-2756	270	1	british	british	ADJ
admet-2756	270	2	journal	journal	PROPN
admet-2756	270	3	of	of	ADP
admet-2756	270	4	pharmacology	pharmacology	NOUN
admet-2756	270	5	178	178	NUM
admet-2756	270	6	(	(	PUNCT
admet-2756	270	7	2021	2021	NUM
admet-2756	270	8	)	)	PUNCT
admet-2756	270	9	2008	2008	NUM
admet-2756	270	10	-	-	SYM
admet-2756	270	11	2025	2025	NUM
admet-2756	270	12	https://doi.org/10.1111/bph.15251	https://doi.org/10.1111/bph.15251	NOUN
admet-2756	270	13	[	[	X
admet-2756	270	14	2	2	NUM
admet-2756	270	15	]	]	X
admet-2756	270	16	m.j	m.j	PROPN
admet-2756	270	17	.	.	PROPN
admet-2756	270	18	rogers	rogers	PROPN
admet-2756	270	19	,	,	PUNCT
admet-2756	270	20	j.	j.	PROPN
admet-2756	270	21	mönkkönen	mönkkönen	PROPN
admet-2756	270	22	,	,	PUNCT
admet-2756	270	23	m.a	m.a	PROPN
admet-2756	270	24	.	.	PROPN
admet-2756	270	25	munoz	munoz	PROPN
admet-2756	270	26	.	.	PUNCT
admet-2756	271	1	molecular	molecular	ADJ
admet-2756	271	2	mechanisms	mechanism	NOUN
admet-2756	271	3	of	of	ADP
admet-2756	271	4	action	action	NOUN
admet-2756	271	5	of	of	ADP
admet-2756	271	6	bisphosphonates	bisphosphonate	NOUN
admet-2756	271	7	and	and	CCONJ
admet-2756	271	8	new	new	ADJ
admet-2756	271	9	insights	insight	NOUN
admet-2756	271	10	into	into	ADP
admet-2756	271	11	their	their	PRON
admet-2756	271	12	effects	effect	NOUN
admet-2756	271	13	outside	outside	ADP
admet-2756	271	14	the	the	DET
admet-2756	271	15	skeleton	skeleton	NOUN
admet-2756	271	16	.	.	PUNCT
admet-2756	272	1	bone	bone	NOUN
admet-2756	272	2	139	139	NUM
admet-2756	272	3	(	(	PUNCT
admet-2756	272	4	2020	2020	NUM
admet-2756	272	5	)	)	PUNCT
admet-2756	272	6	115493	115493	NUM
admet-2756	272	7	https://doi.org/10.1016/j.bone.2020.115493	https://doi.org/10.1016/j.bone.2020.115493	PROPN
admet-2756	273	1	[	[	X
admet-2756	273	2	3	3	X
admet-2756	273	3	]	]	X
admet-2756	273	4	b.	b.	PROPN
admet-2756	273	5	clarke	clarke	PROPN
admet-2756	273	6	.	.	PUNCT
admet-2756	274	1	normal	normal	ADJ
admet-2756	274	2	bone	bone	NOUN
admet-2756	274	3	anatomy	anatomy	NOUN
admet-2756	274	4	and	and	CCONJ
admet-2756	274	5	physiology	physiology	NOUN
admet-2756	274	6	.	.	PUNCT
admet-2756	275	1	clinical	clinical	ADJ
admet-2756	275	2	journal	journal	NOUN
admet-2756	275	3	of	of	ADP
admet-2756	275	4	the	the	DET
admet-2756	275	5	american	american	ADJ
admet-2756	275	6	society	society	NOUN
admet-2756	275	7	of	of	ADP
admet-2756	275	8	nephrology	nephrology	NOUN
admet-2756	275	9	:	:	PUNCT
admet-2756	275	10	cjasn	cjasn	VERB
admet-2756	275	11	3	3	NUM
admet-2756	275	12	(	(	PUNCT
admet-2756	275	13	2008	2008	NUM
admet-2756	275	14	)	)	PUNCT
admet-2756	275	15	131	131	NUM
admet-2756	275	16	-	-	SYM
admet-2756	275	17	139	139	NUM
admet-2756	275	18	https://doi.org/10.2215/cjn.04151206	https://doi.org/10.2215/cjn.04151206	NOUN
admet-2756	275	19	[	[	X
admet-2756	275	20	4	4	NUM
admet-2756	275	21	]	]	X
admet-2756	275	22	g.h	g.h	PROPN
admet-2756	275	23	.	.	PROPN
admet-2756	275	24	nancollas	nancollas	PROPN
admet-2756	275	25	,	,	PUNCT
admet-2756	275	26	r.	r.	PROPN
admet-2756	275	27	tang	tang	PROPN
admet-2756	275	28	,	,	PUNCT
admet-2756	275	29	r.j	r.j	PROPN
admet-2756	275	30	.	.	PROPN
admet-2756	275	31	phipps	phipps	PROPN
admet-2756	275	32	,	,	PUNCT
admet-2756	275	33	z.	z.	PROPN
admet-2756	275	34	henneman	henneman	PROPN
admet-2756	275	35	,	,	PUNCT
admet-2756	275	36	s.	s.	PROPN
admet-2756	275	37	gulde	gulde	PROPN
admet-2756	275	38	,	,	PUNCT
admet-2756	275	39	w.	w.	PROPN
admet-2756	275	40	wu	wu	PROPN
admet-2756	275	41	,	,	PUNCT
admet-2756	275	42	a.	a.	PROPN
admet-2756	275	43	mangood	mangood	PROPN
admet-2756	275	44	,	,	PUNCT
admet-2756	275	45	r.g.g	r.g.g	PROPN
admet-2756	275	46	.	.	PROPN
admet-2756	276	1	russell	russell	PROPN
admet-2756	276	2	,	,	PUNCT
admet-2756	276	3	f.h	f.h	PROPN
admet-2756	276	4	.	.	PROPN
admet-2756	276	5	ebetino	ebetino	PROPN
admet-2756	276	6	.	.	PUNCT
admet-2756	277	1	novel	novel	ADJ
admet-2756	277	2	insights	insight	NOUN
admet-2756	277	3	into	into	ADP
admet-2756	277	4	actions	action	NOUN
admet-2756	277	5	of	of	ADP
admet-2756	277	6	bisphosphonates	bisphosphonate	NOUN
admet-2756	277	7	on	on	ADP
admet-2756	277	8	bone	bone	NOUN
admet-2756	277	9	:	:	PUNCT
admet-2756	277	10	differences	difference	NOUN
admet-2756	277	11	in	in	ADP
admet-2756	277	12	interactions	interaction	NOUN
admet-2756	277	13	with	with	ADP
admet-2756	277	14	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	277	15	.	.	PUNCT
admet-2756	278	1	bone	bone	NOUN
admet-2756	278	2	38	38	NUM
admet-2756	278	3	(	(	PUNCT
admet-2756	278	4	2006	2006	NUM
admet-2756	278	5	)	)	PUNCT
admet-2756	278	6	617	617	NUM
admet-2756	278	7	-	-	SYM
admet-2756	278	8	627	627	NUM
admet-2756	278	9	https://doi.org/10.1016/j.bone.2005.05.003	https://doi.org/10.1016/j.bone.2005.05.003	NOUN
admet-2756	278	10	[	[	X
admet-2756	278	11	5	5	NUM
admet-2756	278	12	]	]	PUNCT
admet-2756	278	13	e.	e.	PROPN
admet-2756	278	14	chiarella	chiarella	PROPN
admet-2756	278	15	,	,	PUNCT
admet-2756	278	16	c.	c.	PROPN
admet-2756	278	17	nisticò	nisticò	PROPN
admet-2756	278	18	,	,	PUNCT
admet-2756	278	19	a.	a.	PROPN
admet-2756	278	20	di	di	PROPN
admet-2756	278	21	vito	vito	PROPN
admet-2756	278	22	,	,	PUNCT
admet-2756	278	23	h.l	h.l	PROPN
admet-2756	278	24	.	.	PROPN
admet-2756	278	25	morrone	morrone	PROPN
admet-2756	278	26	,	,	PUNCT
admet-2756	278	27	m.	m.	NOUN
admet-2756	278	28	mesuraca	mesuraca	PROPN
admet-2756	278	29	.	.	PUNCT
admet-2756	279	1	targeting	target	VERB
admet-2756	279	2	of	of	ADP
admet-2756	279	3	mevalonate	mevalonate	NOUN
admet-2756	279	4	-	-	PUNCT
admet-2756	279	5	isoprenoid	isoprenoid	NOUN
admet-2756	279	6	pathway	pathway	NOUN
admet-2756	279	7	in	in	ADP
admet-2756	279	8	acute	acute	ADJ
admet-2756	279	9	myeloid	myeloid	NOUN
admet-2756	279	10	leukemia	leukemia	NOUN
admet-2756	279	11	cells	cell	NOUN
admet-2756	279	12	by	by	ADP
admet-2756	279	13	bisphosphonate	bisphosphonate	NOUN
admet-2756	279	14	drugs	drug	NOUN
admet-2756	279	15	.	.	PUNCT
admet-2756	280	1	biomedicines	biomedicine	VERB
admet-2756	280	2	10	10	NUM
admet-2756	280	3	(	(	PUNCT
admet-2756	280	4	2022	2022	NUM
admet-2756	280	5	)	)	PUNCT
admet-2756	280	6	1146	1146	NUM
admet-2756	280	7	https://doi.org/10.3390/biomedicines10051146	https://doi.org/10.3390/biomedicines10051146	X
admet-2756	281	1	[	[	X
admet-2756	281	2	6	6	NUM
admet-2756	281	3	]	]	PUNCT
admet-2756	281	4	z.	z.	PROPN
admet-2756	281	5	mbese	mbese	PROPN
admet-2756	281	6	,	,	PUNCT
admet-2756	281	7	b.a	b.a	PROPN
admet-2756	281	8	.	.	PROPN
admet-2756	281	9	aderibigbe	aderibigbe	PROPN
admet-2756	281	10	.	.	PUNCT
admet-2756	282	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	282	2	-	-	PUNCT
admet-2756	282	3	based	base	VERB
admet-2756	282	4	conjugates	conjugate	NOUN
admet-2756	282	5	and	and	CCONJ
admet-2756	282	6	derivatives	derivative	NOUN
admet-2756	282	7	as	as	ADP
admet-2756	282	8	potential	potential	ADJ
admet-2756	282	9	therapeutic	therapeutic	ADJ
admet-2756	282	10	agents	agent	NOUN
admet-2756	282	11	in	in	ADP
admet-2756	282	12	osteoporosis	osteoporosis	NOUN
admet-2756	282	13	,	,	PUNCT
admet-2756	282	14	bone	bone	NOUN
admet-2756	282	15	cancer	cancer	NOUN
admet-2756	282	16	and	and	CCONJ
admet-2756	282	17	metastatic	metastatic	ADJ
admet-2756	282	18	bone	bone	NOUN
admet-2756	282	19	cancer	cancer	NOUN
admet-2756	282	20	.	.	PUNCT
admet-2756	283	1	international	international	ADJ
admet-2756	283	2	journal	journal	NOUN
admet-2756	283	3	of	of	ADP
admet-2756	283	4	molecular	molecular	ADJ
admet-2756	283	5	sciences	science	NOUN
admet-2756	283	6	22	22	NUM
admet-2756	283	7	(	(	PUNCT
admet-2756	283	8	2021	2021	NUM
admet-2756	283	9	)	)	PUNCT
admet-2756	283	10	6869	6869	NUM
admet-2756	283	11	https://doi.org/10.3390/ijms22136869	https://doi.org/10.3390/ijms22136869	NOUN
admet-2756	283	12	[	[	X
admet-2756	283	13	7	7	NUM
admet-2756	283	14	]	]	PUNCT
admet-2756	283	15	a.	a.	NOUN
admet-2756	283	16	kuźnik	kuźnik	PROPN
admet-2756	283	17	,	,	PUNCT
admet-2756	283	18	a.	a.	PROPN
admet-2756	283	19	październiok	październiok	PROPN
admet-2756	283	20	-	-	PUNCT
admet-2756	283	21	holewa	holewa	PROPN
admet-2756	283	22	,	,	PUNCT
admet-2756	283	23	p.	p.	NOUN
admet-2756	283	24	jewula	jewula	NOUN
admet-2756	283	25	,	,	PUNCT
admet-2756	283	26	n.	n.	PROPN
admet-2756	283	27	kuźnik	kuźnik	PROPN
admet-2756	283	28	.	.	PUNCT
admet-2756	284	1	bisphosphonates	bisphosphonate	NOUN
admet-2756	284	2	—	—	PUNCT
admet-2756	284	3	much	much	ADV
admet-2756	284	4	more	more	ADJ
admet-2756	284	5	than	than	ADP
admet-2756	284	6	only	only	ADJ
admet-2756	284	7	drugs	drug	NOUN
admet-2756	284	8	for	for	ADP
admet-2756	284	9	bone	bone	NOUN
admet-2756	284	10	diseases	disease	NOUN
admet-2756	284	11	.	.	PUNCT
admet-2756	285	1	european	european	ADJ
admet-2756	285	2	journal	journal	PROPN
admet-2756	285	3	of	of	ADP
admet-2756	285	4	pharmacology	pharmacology	PROPN
admet-2756	285	5	866	866	NUM
admet-2756	285	6	(	(	PUNCT
admet-2756	285	7	2020	2020	NUM
admet-2756	285	8	)	)	PUNCT
admet-2756	285	9	172773	172773	NUM
admet-2756	286	1	https://doi.org/10.1016/j.ejphar.2019.172773	https://doi.org/10.1016/j.ejphar.2019.172773	PROPN
admet-2756	286	2	[	[	X
admet-2756	286	3	8	8	NUM
admet-2756	286	4	]	]	X
admet-2756	286	5	j.c	j.c	PROPN
admet-2756	286	6	.	.	PROPN
admet-2756	286	7	branco	branco	PROPN
admet-2756	286	8	santos	santos	PROPN
admet-2756	286	9	,	,	PUNCT
admet-2756	286	10	j.a	j.a	PROPN
admet-2756	286	11	.	.	PROPN
admet-2756	286	12	de	de	PROPN
admet-2756	286	13	melo	melo	PROPN
admet-2756	286	14	,	,	PUNCT
admet-2756	286	15	s.	s.	PROPN
admet-2756	286	16	maheshwari	maheshwari	PROPN
admet-2756	286	17	,	,	PUNCT
admet-2756	286	18	w.m.t.q	w.m.t.q	PROPN
admet-2756	286	19	.	.	PROPN
admet-2756	286	20	de	de	PROPN
admet-2756	286	21	medeiros	medeiros	PROPN
admet-2756	286	22	,	,	PUNCT
admet-2756	286	23	j.w	j.w	PROPN
admet-2756	286	24	.	.	PROPN
admet-2756	286	25	de	de	PROPN
admet-2756	286	26	freitas	freitas	PROPN
admet-2756	286	27	oliveira	oliveira	PROPN
admet-2756	286	28	,	,	PUNCT
admet-2756	286	29	c.j	c.j	PROPN
admet-2756	286	30	.	.	PROPN
admet-2756	286	31	moreno	moreno	PROPN
admet-2756	286	32	,	,	PUNCT
admet-2756	286	33	l.	l.	PROPN
admet-2756	286	34	mario	mario	PROPN
admet-2756	286	35	amzel	amzel	PROPN
admet-2756	286	36	,	,	PUNCT
admet-2756	286	37	s.b	s.b	PROPN
admet-2756	286	38	.	.	PROPN
admet-2756	286	39	gabelli	gabelli	PROPN
admet-2756	286	40	,	,	PUNCT
admet-2756	286	41	m.	m.	PROPN
admet-2756	286	42	sousa	sousa	PROPN
admet-2756	286	43	silva	silva	PROPN
admet-2756	286	44	.	.	PUNCT
admet-2756	287	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	287	2	-	-	PUNCT
admet-2756	287	3	based	base	VERB
admet-2756	287	4	molecules	molecule	NOUN
admet-2756	287	5	as	as	ADP
admet-2756	287	6	potential	potential	ADJ
admet-2756	287	7	new	new	ADJ
admet-2756	287	8	antiparasitic	antiparasitic	ADJ
admet-2756	287	9	drugs	drug	NOUN
admet-2756	287	10	.	.	PUNCT
admet-2756	288	1	molecules	molecule	NOUN
admet-2756	288	2	25	25	NUM
admet-2756	288	3	(	(	PUNCT
admet-2756	288	4	2020	2020	NUM
admet-2756	288	5	)	)	PUNCT
admet-2756	288	6	2602	2602	NUM
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admet-2756	288	8	[	[	X
admet-2756	288	9	9	9	NUM
admet-2756	288	10	]	]	X
admet-2756	288	11	j.r	j.r	PROPN
admet-2756	288	12	.	.	PROPN
admet-2756	288	13	center	center	PROPN
admet-2756	288	14	,	,	PUNCT
admet-2756	288	15	k.w	k.w	PROPN
admet-2756	288	16	.	.	PROPN
admet-2756	288	17	lyles	lyles	PROPN
admet-2756	288	18	,	,	PUNCT
admet-2756	288	19	d.	d.	PROPN
admet-2756	288	20	bliuc	bliuc	PROPN
admet-2756	288	21	.	.	PUNCT
admet-2756	289	1	bisphosphonates	bisphosphonate	NOUN
admet-2756	289	2	and	and	CCONJ
admet-2756	289	3	lifespan	lifespan	NOUN
admet-2756	289	4	.	.	PUNCT
admet-2756	290	1	bone	bone	NOUN
admet-2756	290	2	141	141	NUM
admet-2756	290	3	(	(	PUNCT
admet-2756	290	4	2020	2020	NUM
admet-2756	290	5	)	)	PUNCT
admet-2756	290	6	115566	115566	NUM
admet-2756	290	7	https://doi.org/10.1016/j.bone.2020.115566	https://doi.org/10.1016/j.bone.2020.115566	ADJ
admet-2756	291	1	[	[	X
admet-2756	291	2	10	10	NUM
admet-2756	291	3	]	]	X
admet-2756	291	4	y.	y.	PROPN
admet-2756	291	5	wu	wu	PROPN
admet-2756	291	6	,	,	PUNCT
admet-2756	291	7	b.	b.	PROPN
admet-2756	291	8	sun	sun	PROPN
admet-2756	291	9	,	,	PUNCT
admet-2756	291	10	y.	y.	PROPN
admet-2756	291	11	tang	tang	PROPN
admet-2756	291	12	,	,	PUNCT
admet-2756	291	13	a.	a.	PROPN
admet-2756	291	14	shen	shen	PROPN
admet-2756	291	15	,	,	PUNCT
admet-2756	291	16	y.	y.	PROPN
admet-2756	291	17	lin	lin	PROPN
admet-2756	291	18	,	,	PUNCT
admet-2756	291	19	x.	x.	PROPN
admet-2756	291	20	zhao	zhao	PROPN
admet-2756	291	21	,	,	PUNCT
admet-2756	291	22	j.	j.	PROPN
admet-2756	291	23	li	li	PROPN
admet-2756	291	24	,	,	PUNCT
admet-2756	291	25	m.j	m.j	PROPN
admet-2756	291	26	.	.	PROPN
admet-2756	291	27	monteiro	monteiro	PROPN
admet-2756	291	28	,	,	PUNCT
admet-2756	291	29	w.	w.	PROPN
admet-2756	291	30	gu	gu	PROPN
admet-2756	291	31	.	.	PROPN
admet-2756	291	32	bone	bone	PROPN
admet-2756	291	33	targeted	target	VERB
admet-2756	291	34	nano	nano	NOUN
admet-2756	291	35	-	-	PUNCT
admet-2756	291	36	drug	drug	NOUN
admet-2756	291	37	and	and	CCONJ
admet-2756	291	38	nano	nano	NOUN
admet-2756	291	39	-	-	PUNCT
admet-2756	291	40	delivery	delivery	NOUN
admet-2756	291	41	.	.	PUNCT
admet-2756	292	1	bone	bone	NOUN
admet-2756	292	2	research	research	NOUN
admet-2756	292	3	12	12	NUM
admet-2756	292	4	(	(	PUNCT
admet-2756	292	5	2024	2024	NUM
admet-2756	292	6	)	)	PUNCT
admet-2756	292	7	51	51	NUM
admet-2756	292	8	https://doi.org/10.1038/s41413-024-00356-2	https://doi.org/10.1038/s41413-024-00356-2	NUM
admet-2756	293	1	[	[	X
admet-2756	293	2	11	11	NUM
admet-2756	293	3	]	]	X
admet-2756	293	4	d.v	d.v	PROPN
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admet-2756	293	7	,	,	PUNCT
admet-2756	293	8	s.l	s.l	PROPN
admet-2756	293	9	.	.	PROPN
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admet-2756	293	11	.	.	PUNCT
admet-2756	294	1	the	the	DET
admet-2756	294	2	osteoclast	osteoclast	ADJ
admet-2756	294	3	:	:	PUNCT
admet-2756	294	4	friend	friend	NOUN
admet-2756	294	5	or	or	CCONJ
admet-2756	294	6	foe	foe	NOUN
admet-2756	294	7	?	?	PUNCT
admet-2756	294	8	annual	annual	ADJ
admet-2756	294	9	review	review	NOUN
admet-2756	294	10	of	of	ADP
admet-2756	294	11	pathology	pathology	NOUN
admet-2756	294	12	:	:	PUNCT
admet-2756	294	13	mechanisms	mechanism	NOUN
admet-2756	294	14	of	of	ADP
admet-2756	294	15	disease	disease	NOUN
admet-2756	294	16	3	3	NUM
admet-2756	294	17	(	(	PUNCT
admet-2756	294	18	2008	2008	NUM
admet-2756	294	19	)	)	PUNCT
admet-2756	294	20	457	457	NUM
admet-2756	294	21	-	-	SYM
admet-2756	294	22	484	484	NUM
admet-2756	294	23	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151431	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151431	NOUN
admet-2756	295	1	[	[	X
admet-2756	295	2	12	12	NUM
admet-2756	295	3	]	]	X
admet-2756	295	4	d.	d.	PROPN
admet-2756	295	5	kimmel	kimmel	PROPN
admet-2756	295	6	.	.	PUNCT
admet-2756	296	1	mechanism	mechanism	NOUN
admet-2756	296	2	of	of	ADP
admet-2756	296	3	action	action	NOUN
admet-2756	296	4	,	,	PUNCT
admet-2756	296	5	pharmacokinetic	pharmacokinetic	ADJ
admet-2756	296	6	and	and	CCONJ
admet-2756	296	7	pharmacodynamic	pharmacodynamic	ADJ
admet-2756	296	8	profile	profile	NOUN
admet-2756	296	9	,	,	PUNCT
admet-2756	296	10	and	and	CCONJ
admet-2756	296	11	clinical	clinical	ADJ
admet-2756	296	12	applications	application	NOUN
admet-2756	296	13	of	of	ADP
admet-2756	296	14	nitrogen	nitrogen	NOUN
admet-2756	296	15	-	-	PUNCT
admet-2756	296	16	containing	contain	VERB
admet-2756	296	17	bisphosphonates	bisphosphonate	NOUN
admet-2756	296	18	.	.	PUNCT
admet-2756	297	1	journal	journal	NOUN
admet-2756	297	2	of	of	ADP
admet-2756	297	3	dental	dental	ADJ
admet-2756	297	4	research	research	NOUN
admet-2756	297	5	86	86	NUM
admet-2756	297	6	(	(	PUNCT
admet-2756	297	7	2007	2007	NUM
admet-2756	297	8	)	)	PUNCT
admet-2756	297	9	10221033	10221033	NUM
admet-2756	297	10	https://doi.org/10.1177/154405910708601102	https://doi.org/10.1177/154405910708601102	NOUN
admet-2756	298	1	[	[	X
admet-2756	298	2	13	13	NUM
admet-2756	298	3	]	]	PUNCT
admet-2756	298	4	m.	m.	NOUN
admet-2756	298	5	van	van	PROPN
admet-2756	298	6	driel	driel	PROPN
admet-2756	298	7	,	,	PUNCT
admet-2756	298	8	j.p	j.p	PROPN
admet-2756	298	9	.	.	PROPN
admet-2756	298	10	van	van	PROPN
admet-2756	298	11	leeuwen	leeuwen	PROPN
admet-2756	298	12	.	.	PUNCT
admet-2756	299	1	cancer	cancer	NOUN
admet-2756	299	2	and	and	CCONJ
admet-2756	299	3	bone	bone	NOUN
admet-2756	299	4	:	:	PUNCT
admet-2756	299	5	a	a	DET
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admet-2756	299	8	.	.	PUNCT
admet-2756	300	1	archives	archive	NOUN
admet-2756	300	2	of	of	ADP
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admet-2756	300	4	and	and	CCONJ
admet-2756	300	5	biophysics	biophysic	NOUN
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admet-2756	300	7	(	(	PUNCT
admet-2756	300	8	2014	2014	NUM
admet-2756	300	9	)	)	PUNCT
admet-2756	300	10	159	159	NUM
admet-2756	300	11	-	-	SYM
admet-2756	300	12	166	166	NUM
admet-2756	300	13	https://doi.org/10.1016/j.abb.2014.07.013	https://doi.org/10.1016/j.abb.2014.07.013	NOUN
admet-2756	301	1	[	[	X
admet-2756	301	2	14	14	NUM
admet-2756	301	3	]	]	X
admet-2756	301	4	h.h	h.h	PROPN
admet-2756	301	5	.	.	PROPN
admet-2756	301	6	van	van	PROPN
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admet-2756	301	8	,	,	PUNCT
admet-2756	301	9	s.	s.	PROPN
admet-2756	301	10	anguille	anguille	PROPN
admet-2756	301	11	,	,	PUNCT
admet-2756	301	12	y.	y.	PROPN
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admet-2756	301	14	,	,	PUNCT
admet-2756	301	15	e.l	e.l	PROPN
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admet-2756	301	20	.	.	PROPN
admet-2756	301	21	van	van	PROPN
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admet-2756	301	23	.	.	PUNCT
admet-2756	302	1	bisphosphonates	bisphosphonate	NOUN
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admet-2756	302	6	mechanisms	mechanism	NOUN
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admet-2756	302	8	action	action	NOUN
admet-2756	302	9	and	and	CCONJ
admet-2756	302	10	lessons	lesson	NOUN
admet-2756	302	11	from	from	ADP
admet-2756	302	12	clinical	clinical	ADJ
admet-2756	302	13	trials	trial	NOUN
admet-2756	302	14	.	.	PUNCT
admet-2756	303	1	pharmacology	pharmacology	NOUN
admet-2756	303	2	&	&	CCONJ
admet-2756	303	3	therapeutics	therapeutic	NOUN
admet-2756	303	4	158	158	NUM
admet-2756	303	5	(	(	PUNCT
admet-2756	303	6	2016	2016	NUM
admet-2756	303	7	)	)	PUNCT
admet-2756	303	8	24	24	NUM
admet-2756	303	9	-	-	SYM
admet-2756	303	10	40	40	NUM
admet-2756	303	11	https://doi.org/10.1016/j.pharmthera.2015.11.008	https://doi.org/10.1016/j.pharmthera.2015.11.008	NOUN
admet-2756	303	12	[	[	X
admet-2756	303	13	15	15	NUM
admet-2756	303	14	]	]	X
admet-2756	303	15	y.	y.	PROPN
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admet-2756	303	18	a.	a.	PROPN
admet-2756	303	19	yu	yu	PROPN
admet-2756	303	20	,	,	PUNCT
admet-2756	303	21	l.	l.	PROPN
admet-2756	303	22	ye	ye	PROPN
admet-2756	303	23	,	,	PUNCT
admet-2756	303	24	g.	g.	PROPN
admet-2756	303	25	zhai	zhai	PROPN
admet-2756	303	26	.	.	PUNCT
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admet-2756	304	7	.	.	PUNCT
admet-2756	305	1	expert	expert	ADJ
admet-2756	305	2	opinion	opinion	NOUN
admet-2756	305	3	on	on	ADP
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admet-2756	305	5	delivery	delivery	NOUN
admet-2756	305	6	18	18	NUM
admet-2756	305	7	(	(	PUNCT
admet-2756	305	8	2021	2021	NUM
admet-2756	305	9	)	)	PUNCT
admet-2756	305	10	1067	1067	NUM
admet-2756	305	11	-	-	SYM
admet-2756	305	12	1090	1090	NUM
admet-2756	305	13	https://doi.org/10.1080/17425247.2021.1882992	https://doi.org/10.1080/17425247.2021.1882992	NOUN
admet-2756	306	1	[	[	X
admet-2756	306	2	16	16	NUM
admet-2756	306	3	]	]	X
admet-2756	306	4	r.a	r.a	PROPN
admet-2756	306	5	.	.	PROPN
admet-2756	306	6	nadar	nadar	PROPN
admet-2756	306	7	,	,	PUNCT
admet-2756	306	8	k.	k.	PROPN
admet-2756	306	9	farbod	farbod	PROPN
admet-2756	306	10	,	,	PUNCT
admet-2756	306	11	k.c.v	k.c.v	PROPN
admet-2756	306	12	der	der	PROPN
admet-2756	306	13	schilden	schilden	PROPN
admet-2756	306	14	,	,	PUNCT
admet-2756	306	15	l.	l.	PROPN
admet-2756	306	16	schlatt	schlatt	PROPN
admet-2756	306	17	,	,	PUNCT
admet-2756	306	18	b.	b.	PROPN
admet-2756	306	19	crone	crone	NOUN
admet-2756	306	20	,	,	PUNCT
admet-2756	306	21	n.	n.	NOUN
admet-2756	306	22	asokan	asokan	ADJ
admet-2756	306	23	,	,	PUNCT
admet-2756	306	24	a.	a.	NOUN
admet-2756	306	25	curci	curci	PROPN
admet-2756	306	26	,	,	PUNCT
admet-2756	306	27	m.	m.	NOUN
admet-2756	306	28	brand	brand	PROPN
admet-2756	306	29	,	,	PUNCT
admet-2756	306	30	bornhaeuser	bornhaeuser	NOUN
admet-2756	306	31	,	,	PUNCT
admet-2756	306	32	m.	m.	PROPN
admet-2756	306	33	iafisco	iafisco	PROPN
admet-2756	306	34	,	,	PUNCT
admet-2756	306	35	m.	m.	NOUN
admet-2756	306	36	margiotta	margiotta	PROPN
admet-2756	306	37	,	,	PUNCT
admet-2756	306	38	u.	u.	PROPN
admet-2756	306	39	karst	karst	PROPN
admet-2756	306	40	,	,	PUNCT
admet-2756	306	41	s.	s.	PROPN
admet-2756	306	42	heskamp	heskamp	PROPN
admet-2756	306	43	,	,	PUNCT
admet-2756	306	44	o.c	o.c	PROPN
admet-2756	306	45	.	.	PROPN
admet-2756	306	46	boerman	boerman	PROPN
admet-2756	306	47	,	,	PUNCT
admet-2756	306	48	j.j.j.p	j.j.j.p	PROPN
admet-2756	306	49	van	van	PROPN
admet-2756	306	50	der	der	PROPN
admet-2756	306	51	beucken	beucken	VERB
admet-2756	306	52	,	,	PUNCT
admet-2756	306	53	s.c.g	s.c.g	PROPN
admet-2756	306	54	.	.	PUNCT
admet-2756	306	55	leeuwenburgh	leeuwenburgh	PROPN
admet-2756	306	56	.	.	PUNCT
admet-2756	307	1	targeting	target	VERB
admet-2756	307	2	of	of	ADP
admet-2756	307	3	radioactive	radioactive	ADJ
admet-2756	307	4	platinum	platinum	NOUN
admet-2756	307	5	-	-	PUNCT
admet-2756	307	6	bisphosphonate	bisphosphonate	NOUN
admet-2756	307	7	anticancer	anticancer	NOUN
admet-2756	307	8	drugs	drug	NOUN
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admet-2756	307	10	bone	bone	NOUN
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admet-2756	307	12	high	high	ADJ
admet-2756	307	13	metabolic	metabolic	NOUN
admet-2756	307	14	activity	activity	NOUN
admet-2756	307	15	.	.	PUNCT
admet-2756	308	1	scientific	scientific	ADJ
admet-2756	308	2	reports	report	NOUN
admet-2756	308	3	10	10	NUM
admet-2756	308	4	(	(	PUNCT
admet-2756	308	5	2020	2020	NUM
admet-2756	308	6	)	)	PUNCT
admet-2756	308	7	5889	5889	NUM
admet-2756	308	8	https://doi.org/10.1038/s41598-020-62039-2	https://doi.org/10.1038/s41598-020-62039-2	NUM
admet-2756	309	1	[	[	X
admet-2756	309	2	17	17	NUM
admet-2756	309	3	]	]	X
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admet-2756	309	5	.	.	PROPN
admet-2756	309	6	nadar	nadar	PROPN
admet-2756	309	7	,	,	PUNCT
admet-2756	309	8	g.m	g.m	PROPN
admet-2756	309	9	.	.	PROPN
admet-2756	309	10	franssen	franssen	PROPN
admet-2756	309	11	,	,	PUNCT
admet-2756	309	12	n.w.m	n.w.m	PROPN
admet-2756	309	13	van	van	PROPN
admet-2756	309	14	dijk	dijk	PROPN
admet-2756	309	15	,	,	PUNCT
admet-2756	309	16	k.	k.	PROPN
admet-2756	309	17	codee	codee	PROPN
admet-2756	309	18	-	-	PUNCT
admet-2756	309	19	van	van	PROPN
admet-2756	309	20	der	der	PROPN
admet-2756	309	21	schilden	schilden	PROPN
admet-2756	309	22	,	,	PUNCT
admet-2756	309	23	m.	m.	NOUN
admet-2756	309	24	de	de	X
admet-2756	309	25	weijert	weijert	PROPN
admet-2756	309	26	,	,	PUNCT
admet-2756	309	27	e.	e.	PROPN
admet-2756	309	28	oosterwijk	oosterwijk	PROPN
admet-2756	309	29	,	,	PUNCT
admet-2756	309	30	m.	m.	PROPN
admet-2756	309	31	iafisco	iafisco	PROPN
admet-2756	309	32	,	,	PUNCT
admet-2756	309	33	n.	n.	PROPN
admet-2756	309	34	margiotta	margiotta	PROPN
admet-2756	309	35	,	,	PUNCT
admet-2756	309	36	s.	s.	PROPN
admet-2756	309	37	heskamp	heskamp	PROPN
admet-2756	309	38	,	,	PUNCT
admet-2756	309	39	j.j.j.p	j.j.j.p	PROPN
admet-2756	309	40	.	.	PUNCT
admet-2756	310	1	van	van	PROPN
admet-2756	310	2	den	den	PROPN
admet-2756	310	3	beucken	beucken	PROPN
admet-2756	310	4	,	,	PUNCT
admet-2756	310	5	s.c.g	s.c.g	PROPN
admet-2756	310	6	.	.	PUNCT
admet-2756	310	7	leeuwenburgh	leeuwenburgh	PROPN
admet-2756	310	8	.	.	PUNCT
admet-2756	311	1	bone	bone	NOUN
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admet-2756	311	3	https://doi.org/10.1111/bph.15251	https://doi.org/10.1111/bph.15251	PROPN
admet-2756	311	4	https://doi.org/10.1016/j.bone.2020.115493	https://doi.org/10.1016/j.bone.2020.115493	PROPN
admet-2756	311	5	https://doi.org/10.2215/cjn.04151206	https://doi.org/10.2215/cjn.04151206	PROPN
admet-2756	311	6	https://doi.org/10.1016/j.bone.2005.05.003	https://doi.org/10.1016/j.bone.2005.05.003	PROPN
admet-2756	311	7	https://doi.org/10.3390/biomedicines10051146	https://doi.org/10.3390/biomedicines10051146	NOUN
admet-2756	311	8	https://doi.org/10.3390/ijms22136869	https://doi.org/10.3390/ijms22136869	PROPN
admet-2756	311	9	https://doi.org/10.1016/j.ejphar.2019.172773	https://doi.org/10.1016/j.ejphar.2019.172773	PROPN
admet-2756	311	10	https://doi.org/10.3390/molecules25112602	https://doi.org/10.3390/molecules25112602	PROPN
admet-2756	311	11	https://doi.org/10.1016/j.bone.2020.115566	https://doi.org/10.1016/j.bone.2020.115566	PROPN
admet-2756	311	12	https://doi.org/10.1038/s41413-024-00356-2	https://doi.org/10.1038/s41413-024-00356-2	PROPN
admet-2756	311	13	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151431	https://doi.org/10.1146/annurev.pathmechdis.3.121806.151431	PROPN
admet-2756	311	14	https://doi.org/10.1177/154405910708601102	https://doi.org/10.1177/154405910708601102	PROPN
admet-2756	311	15	https://doi.org/10.1016/j.abb.2014.07.013	https://doi.org/10.1016/j.abb.2014.07.013	PROPN
admet-2756	311	16	https://doi.org/10.1016/j.pharmthera.2015.11.008	https://doi.org/10.1016/j.pharmthera.2015.11.008	PROPN
admet-2756	311	17	https://doi.org/10.1080/17425247.2021.1882992	https://doi.org/10.1080/17425247.2021.1882992	PROPN
admet-2756	312	1	https://doi.org/10.1038/s41598-020-62039-2	https://doi.org/10.1038/s41598-020-62039-2	PROPN
admet-2756	312	2	m.	m.	PROPN
admet-2756	312	3	eshaghi	eshaghi	PROPN
admet-2756	312	4	et	et	PROPN
admet-2756	312	5	al	al	PROPN
admet-2756	312	6	.	.	PROPN
admet-2756	312	7	admet	admet	PROPN
admet-2756	312	8	&	&	CCONJ
admet-2756	312	9	dmpk	dmpk	PROPN
admet-2756	312	10	13(3	13(3	NUM
admet-2756	312	11	)	)	PUNCT
admet-2756	312	12	(	(	PUNCT
admet-2756	312	13	2025	2025	NUM
admet-2756	312	14	)	)	PUNCT
admet-2756	312	15	2756	2756	NUM
admet-2756	312	16	14	14	NUM
admet-2756	312	17	targeted	target	VERB
admet-2756	312	18	delivery	delivery	NOUN
admet-2756	312	19	of	of	ADP
admet-2756	312	20	theranostic	theranostic	ADJ
admet-2756	312	21	195mpt	195mpt	NUM
admet-2756	312	22	-	-	PUNCT
admet-2756	312	23	bisphosphonate	bisphosphonate	NOUN
admet-2756	312	24	complexes	complex	NOUN
admet-2756	312	25	promotes	promote	VERB
admet-2756	312	26	killing	kill	VERB
admet-2756	312	27	of	of	ADP
admet-2756	312	28	metastatic	metastatic	ADJ
admet-2756	312	29	tumor	tumor	NOUN
admet-2756	312	30	cells	cell	NOUN
admet-2756	312	31	.	.	PUNCT
admet-2756	313	1	materials	material	NOUN
admet-2756	313	2	today	today	NOUN
admet-2756	313	3	bio	bio	NOUN
admet-2756	313	4	9	9	NUM
admet-2756	313	5	(	(	PUNCT
admet-2756	313	6	2021	2021	NUM
admet-2756	313	7	)	)	PUNCT
admet-2756	313	8	100088	100088	NUM
admet-2756	314	1	https://doi.org/10.1016/j.mtbio.2020.100088	https://doi.org/10.1016/j.mtbio.2020.100088	NOUN
admet-2756	315	1	[	[	X
admet-2756	315	2	18	18	NUM
admet-2756	315	3	]	]	SYM
admet-2756	315	4	a.a	a.a	PROPN
admet-2756	315	5	.	.	PROPN
admet-2756	315	6	fathy	fathy	PROPN
admet-2756	315	7	,	,	PUNCT
admet-2756	315	8	i.s	i.s	PROPN
admet-2756	315	9	.	.	PROPN
admet-2756	315	10	butler	butler	PROPN
admet-2756	315	11	,	,	PUNCT
admet-2756	315	12	m.	m.	PROPN
admet-2756	315	13	abd	abd	PROPN
admet-2756	315	14	elrahman	elrahman	PROPN
admet-2756	315	15	,	,	PUNCT
admet-2756	315	16	b.j	b.j	PROPN
admet-2756	315	17	.	.	PROPN
admet-2756	315	18	jean	jean	PROPN
admet-2756	315	19	-	-	PUNCT
admet-2756	315	20	claude	claude	PROPN
admet-2756	315	21	,	,	PUNCT
admet-2756	315	22	s.i	s.i	PROPN
admet-2756	315	23	.	.	PROPN
admet-2756	315	24	mostafa	mostafa	PROPN
admet-2756	315	25	.	.	PUNCT
admet-2756	316	1	anticancer	anticancer	NOUN
admet-2756	316	2	evaluation	evaluation	NOUN
admet-2756	316	3	and	and	CCONJ
admet-2756	316	4	drug	drug	NOUN
admet-2756	316	5	delivery	delivery	NOUN
admet-2756	316	6	of	of	ADP
admet-2756	316	7	new	new	ADJ
admet-2756	316	8	palladium	palladium	NOUN
admet-2756	316	9	(	(	PUNCT
admet-2756	316	10	ii	ii	NOUN
admet-2756	316	11	)	)	PUNCT
admet-2756	316	12	complexes	complex	NOUN
admet-2756	316	13	based	base	VERB
admet-2756	316	14	on	on	ADP
admet-2756	316	15	the	the	DET
admet-2756	316	16	chelate	chelate	NOUN
admet-2756	316	17	of	of	ADP
admet-2756	316	18	alendronate	alendronate	NOUN
admet-2756	316	19	onto	onto	ADP
admet-2756	316	20	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	316	21	nanoparticles	nanoparticle	NOUN
admet-2756	316	22	.	.	PUNCT
admet-2756	317	1	inorganica	inorganica	PROPN
admet-2756	317	2	chimica	chimica	PROPN
admet-2756	317	3	acta	acta	PROPN
admet-2756	317	4	473	473	NUM
admet-2756	317	5	(	(	PUNCT
admet-2756	317	6	2018	2018	NUM
admet-2756	317	7	)	)	PUNCT
admet-2756	317	8	44	44	NUM
admet-2756	317	9	-	-	SYM
admet-2756	317	10	50	50	NUM
admet-2756	317	11	https://doi.org/10.1016/j.ica.2017.12.015	https://doi.org/10.1016/j.ica.2017.12.015	NOUN
admet-2756	317	12	[	[	X
admet-2756	317	13	19	19	NUM
admet-2756	317	14	]	]	X
admet-2756	317	15	s.	s.	PROPN
admet-2756	317	16	shakori	shakori	PROPN
admet-2756	317	17	poshteh	poshteh	PROPN
admet-2756	317	18	,	,	PUNCT
admet-2756	317	19	s.	s.	PROPN
admet-2756	317	20	alipour	alipour	PROPN
admet-2756	317	21	,	,	PUNCT
admet-2756	317	22	p.	p.	PROPN
admet-2756	317	23	varamini	varamini	PROPN
admet-2756	317	24	.	.	PUNCT
admet-2756	318	1	harnessing	harness	VERB
admet-2756	318	2	curcumin	curcumin	NOUN
admet-2756	318	3	and	and	CCONJ
admet-2756	318	4	nanotechnology	nanotechnology	NOUN
admet-2756	318	5	for	for	ADP
admet-2756	318	6	enhanced	enhanced	ADJ
admet-2756	318	7	treatment	treatment	NOUN
admet-2756	318	8	of	of	ADP
admet-2756	318	9	breast	breast	NOUN
admet-2756	318	10	cancer	cancer	NOUN
admet-2756	318	11	bone	bone	NOUN
admet-2756	318	12	metastasis	metastasis	NOUN
admet-2756	318	13	.	.	PUNCT
admet-2756	319	1	discover	discover	VERB
admet-2756	319	2	nano	nano	NOUN
admet-2756	319	3	19	19	NUM
admet-2756	319	4	(	(	PUNCT
admet-2756	319	5	2024	2024	NUM
admet-2756	319	6	)	)	PUNCT
admet-2756	319	7	177	177	NUM
admet-2756	319	8	https://doi.org/10.1186/s11671-024-04126-1	https://doi.org/10.1186/s11671-024-04126-1	NOUN
admet-2756	319	9	[	[	X
admet-2756	319	10	20	20	NUM
admet-2756	319	11	]	]	X
admet-2756	319	12	c.	c.	PROPN
admet-2756	319	13	schem	schem	PROPN
admet-2756	319	14	,	,	PUNCT
admet-2756	319	15	r.j	r.j	PROPN
admet-2756	319	16	.	.	PROPN
admet-2756	319	17	tower	tower	PROPN
admet-2756	319	18	,	,	PUNCT
admet-2756	319	19	p.	p.	PROPN
admet-2756	319	20	kneissl	kneissl	PROPN
admet-2756	319	21	,	,	PUNCT
admet-2756	319	22	a.c	a.c	PROPN
admet-2756	319	23	.	.	PROPN
admet-2756	319	24	rambow	rambow	PROPN
admet-2756	319	25	,	,	PUNCT
admet-2756	319	26	g.m	g.m	PROPN
admet-2756	319	27	.	.	PUNCT
admet-2756	319	28	campbell	campbell	PROPN
admet-2756	319	29	,	,	PUNCT
admet-2756	319	30	c.	c.	PROPN
admet-2756	319	31	desel	desel	PROPN
admet-2756	319	32	,	,	PUNCT
admet-2756	319	33	t.	t.	PROPN
admet-2756	319	34	damm	damm	PROPN
admet-2756	319	35	,	,	PUNCT
admet-2756	319	36	t.	t.	PROPN
admet-2756	319	37	heilmann	heilmann	PROPN
admet-2756	319	38	,	,	PUNCT
admet-2756	319	39	s.	s.	PROPN
admet-2756	319	40	fuchs	fuchs	PROPN
admet-2756	319	41	,	,	PUNCT
admet-2756	319	42	m.	m.	NOUN
admet-2756	319	43	zuhayra	zuhayra	PROPN
admet-2756	319	44	,	,	PUNCT
admet-2756	319	45	a.	a.	NOUN
admet-2756	319	46	trauzold	trauzold	NOUN
admet-2756	319	47	.	.	PUNCT
admet-2756	320	1	pharmacologically	pharmacologically	ADV
admet-2756	320	2	inactive	inactive	ADJ
admet-2756	320	3	bisphosphonates	bisphosphonate	NOUN
admet-2756	320	4	as	as	ADP
admet-2756	320	5	an	an	DET
admet-2756	320	6	alternative	alternative	ADJ
admet-2756	320	7	strategy	strategy	NOUN
admet-2756	320	8	for	for	ADP
admet-2756	320	9	targeting	target	VERB
admet-2756	320	10	osteoclasts	osteoclast	NOUN
admet-2756	320	11	:	:	PUNCT
admet-2756	320	12	in	in	ADP
admet-2756	320	13	vivo	vivo	ADJ
admet-2756	320	14	assessment	assessment	NOUN
admet-2756	320	15	of	of	ADP
admet-2756	320	16	5	5	NUM
admet-2756	320	17	-	-	PUNCT
admet-2756	320	18	fluorodeoxyuridine	fluorodeoxyuridine	NOUN
admet-2756	320	19	-	-	PUNCT
admet-2756	320	20	alendronate	alendronate	NOUN
admet-2756	320	21	in	in	ADP
admet-2756	320	22	a	a	DET
admet-2756	320	23	preclinical	preclinical	ADJ
admet-2756	320	24	model	model	NOUN
admet-2756	320	25	of	of	ADP
admet-2756	320	26	breast	breast	NOUN
admet-2756	320	27	cancer	cancer	NOUN
admet-2756	320	28	bone	bone	NOUN
admet-2756	320	29	metastases	metastasis	NOUN
admet-2756	320	30	.	.	PUNCT
admet-2756	321	1	journal	journal	PROPN
admet-2756	321	2	of	of	ADP
admet-2756	321	3	bone	bone	NOUN
admet-2756	321	4	and	and	CCONJ
admet-2756	321	5	mineral	mineral	NOUN
admet-2756	321	6	research	research	NOUN
admet-2756	321	7	32	32	NUM
admet-2756	321	8	(	(	PUNCT
admet-2756	321	9	2017	2017	NUM
admet-2756	321	10	)	)	PUNCT
admet-2756	321	11	536	536	NUM
admet-2756	321	12	-	-	SYM
admet-2756	321	13	548	548	NUM
admet-2756	321	14	https://doi.org/10.1002/jbmr.3012	https://doi.org/10.1002/jbmr.3012	NOUN
admet-2756	321	15	[	[	X
admet-2756	321	16	21	21	NUM
admet-2756	321	17	]	]	X
admet-2756	321	18	w.l	w.l	PROPN
admet-2756	321	19	.	.	PROPN
admet-2756	321	20	ye	ye	PROPN
admet-2756	321	21	,	,	PUNCT
admet-2756	321	22	y.p	y.p	PROPN
admet-2756	321	23	.	.	PROPN
admet-2756	321	24	zhao	zhao	PROPN
admet-2756	321	25	,	,	PUNCT
admet-2756	321	26	r.	r.	PROPN
admet-2756	321	27	na	na	PROPN
admet-2756	321	28	,	,	PUNCT
admet-2756	321	29	f.	f.	PROPN
admet-2756	321	30	li	li	PROPN
admet-2756	321	31	,	,	PUNCT
admet-2756	321	32	q.b	q.b	PROPN
admet-2756	321	33	.	.	PROPN
admet-2756	321	34	mei	mei	PROPN
admet-2756	321	35	,	,	PUNCT
admet-2756	321	36	m.g	m.g	PROPN
admet-2756	321	37	.	.	PROPN
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admet-2756	321	39	,	,	PUNCT
admet-2756	322	1	s.y	s.y	PROPN
admet-2756	322	2	.	.	PROPN
admet-2756	322	3	zhou	zhou	PROPN
admet-2756	322	4	.	.	PUNCT
admet-2756	323	1	actively	actively	ADV
admet-2756	323	2	targeted	target	VERB
admet-2756	323	3	delivery	delivery	NOUN
admet-2756	323	4	of	of	ADP
admet-2756	323	5	doxorubicin	doxorubicin	PROPN
admet-2756	323	6	to	to	ADP
admet-2756	323	7	bone	bone	NOUN
admet-2756	323	8	metastases	metastasis	NOUN
admet-2756	323	9	by	by	ADP
admet-2756	323	10	a	a	DET
admet-2756	323	11	ph	ph	ADJ
admet-2756	323	12	-	-	ADJ
admet-2756	323	13	sensitive	sensitive	ADJ
admet-2756	323	14	conjugation	conjugation	NOUN
admet-2756	323	15	.	.	PUNCT
admet-2756	324	1	journal	journal	PROPN
admet-2756	324	2	of	of	ADP
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admet-2756	324	4	sciences	science	NOUN
admet-2756	324	5	104	104	NUM
admet-2756	324	6	(	(	PUNCT
admet-2756	324	7	2015	2015	NUM
admet-2756	324	8	)	)	PUNCT
admet-2756	324	9	2293	2293	NUM
admet-2756	324	10	-	-	SYM
admet-2756	324	11	2303	2303	NUM
admet-2756	324	12	https://doi.org/10.1002/jps.24476	https://doi.org/10.1002/jps.24476	PROPN
admet-2756	325	1	[	[	X
admet-2756	325	2	22	22	NUM
admet-2756	325	3	]	]	PUNCT
admet-2756	325	4	a.	a.	PROPN
admet-2756	325	5	alvarez	alvarez	PROPN
admet-2756	325	6	-	-	PUNCT
admet-2756	325	7	valdes	valdes	PROPN
admet-2756	325	8	,	,	PUNCT
admet-2756	325	9	a.i	a.i	PROPN
admet-2756	325	10	.	.	PROPN
admet-2756	325	11	matesanz	matesanz	PROPN
admet-2756	325	12	,	,	PUNCT
admet-2756	325	13	j.	j.	PROPN
admet-2756	325	14	perles	perles	PROPN
admet-2756	325	15	,	,	PUNCT
admet-2756	325	16	c.	c.	PROPN
admet-2756	325	17	fernandes	fernandes	PROPN
admet-2756	325	18	,	,	PUNCT
admet-2756	325	19	j.d	j.d	PROPN
admet-2756	325	20	.	.	PROPN
admet-2756	325	21	correia	correia	PROPN
admet-2756	325	22	,	,	PUNCT
admet-2756	325	23	f.	f.	PROPN
admet-2756	325	24	mendes	mendes	PROPN
admet-2756	325	25	,	,	PUNCT
admet-2756	325	26	a.g	a.g	PROPN
admet-2756	325	27	.	.	PROPN
admet-2756	325	28	quiroga	quiroga	PROPN
admet-2756	325	29	.	.	PUNCT
admet-2756	326	1	novel	novel	ADJ
admet-2756	326	2	structures	structure	NOUN
admet-2756	326	3	of	of	ADP
admet-2756	326	4	platinum	platinum	NOUN
admet-2756	326	5	complexes	complex	NOUN
admet-2756	326	6	bearing	bear	VERB
admet-2756	326	7	n‑bisphosphonates	n‑bisphosphonates	PROPN
admet-2756	326	8	and	and	CCONJ
admet-2756	326	9	study	study	NOUN
admet-2756	326	10	of	of	ADP
admet-2756	326	11	their	their	PRON
admet-2756	326	12	biological	biological	ADJ
admet-2756	326	13	properties	property	NOUN
admet-2756	326	14	.	.	PUNCT
admet-2756	327	1	journal	journal	PROPN
admet-2756	327	2	of	of	ADP
admet-2756	327	3	inorganic	inorganic	ADJ
admet-2756	327	4	biochemistry	biochemistry	NOUN
admet-2756	327	5	191	191	NUM
admet-2756	327	6	(	(	PUNCT
admet-2756	327	7	2019	2019	NUM
admet-2756	327	8	)	)	PUNCT
admet-2756	327	9	112	112	NUM
admet-2756	327	10	-	-	SYM
admet-2756	327	11	118	118	NUM
admet-2756	328	1	https://doi.org/10.1016/j.jinorgbio.2018.11.010	https://doi.org/10.1016/j.jinorgbio.2018.11.010	PROPN
admet-2756	328	2	[	[	X
admet-2756	328	3	23	23	NUM
admet-2756	328	4	]	]	X
admet-2756	328	5	e.	e.	PROPN
admet-2756	328	6	david	david	PROPN
admet-2756	328	7	,	,	PUNCT
admet-2756	328	8	s.	s.	PROPN
admet-2756	328	9	cagnol	cagnol	PROPN
admet-2756	328	10	,	,	PUNCT
admet-2756	328	11	j.y	j.y	PROPN
admet-2756	328	12	.	.	PROPN
admet-2756	328	13	goujon	goujon	PROPN
admet-2756	328	14	,	,	PUNCT
admet-2756	328	15	m.	m.	NOUN
admet-2756	328	16	egorov	egorov	PROPN
admet-2756	328	17	,	,	PUNCT
admet-2756	328	18	j.	j.	PROPN
admet-2756	328	19	taurelle	taurelle	PROPN
admet-2756	328	20	,	,	PUNCT
admet-2756	328	21	c.	c.	PROPN
admet-2756	328	22	benesteau	benesteau	PROPN
admet-2756	328	23	,	,	PUNCT
admet-2756	328	24	l.	l.	PROPN
admet-2756	328	25	morandeau	morandeau	PROPN
admet-2756	328	26	,	,	PUNCT
admet-2756	328	27	c.	c.	PROPN
admet-2756	328	28	moal	moal	PROPN
admet-2756	328	29	,	,	PUNCT
admet-2756	328	30	m.	m.	NOUN
admet-2756	328	31	sicard	sicard	NOUN
admet-2756	328	32	,	,	PUNCT
admet-2756	328	33	s.	s.	PROPN
admet-2756	328	34	pairel	pairel	PROPN
admet-2756	328	35	,	,	PUNCT
admet-2756	328	36	d.	d.	PROPN
admet-2756	328	37	heymann	heymann	PROPN
admet-2756	328	38	.	.	PUNCT
admet-2756	328	39	12b80	12b80	NUM
admet-2756	328	40	–	–	PUNCT
admet-2756	328	41	hydroxybisphosphonate	hydroxybisphosphonate	ADV
admet-2756	328	42	linked	link	VERB
admet-2756	328	43	doxorubicin	doxorubicin	PROPN
admet-2756	328	44	:	:	PUNCT
admet-2756	328	45	bone	bone	NOUN
admet-2756	328	46	targeted	target	VERB
admet-2756	328	47	strategy	strategy	NOUN
admet-2756	328	48	for	for	ADP
admet-2756	328	49	treatment	treatment	NOUN
admet-2756	328	50	of	of	ADP
admet-2756	328	51	osteosarcoma	osteosarcoma	NOUN
admet-2756	328	52	.	.	PUNCT
admet-2756	329	1	bioconjugate	bioconjugate	NOUN
admet-2756	329	2	chemistry	chemistry	NOUN
admet-2756	329	3	30	30	NUM
admet-2756	329	4	(	(	PUNCT
admet-2756	329	5	2019	2019	NUM
admet-2756	329	6	)	)	PUNCT
admet-2756	329	7	1665	1665	NUM
admet-2756	329	8	-	-	SYM
admet-2756	329	9	1676	1676	NUM
admet-2756	329	10	https://doi.org/10.1021/acs.bioconjchem.9b00210	https://doi.org/10.1021/acs.bioconjchem.9b00210	NOUN
admet-2756	329	11	[	[	X
admet-2756	329	12	24	24	NUM
admet-2756	329	13	]	]	PUNCT
admet-2756	329	14	j.	j.	PROPN
admet-2756	329	15	tao	tao	PROPN
admet-2756	329	16	,	,	PUNCT
admet-2756	329	17	v.	v.	ADP
admet-2756	329	18	srinivasan	srinivasan	NOUN
admet-2756	329	19	,	,	PUNCT
admet-2756	329	20	x.	x.	NOUN
admet-2756	329	21	yi	yi	PROPN
admet-2756	329	22	,	,	PUNCT
admet-2756	329	23	y.	y.	PROPN
admet-2756	329	24	zhao	zhao	PROPN
admet-2756	329	25	,	,	PUNCT
admet-2756	329	26	h.	h.	PROPN
admet-2756	329	27	zhang	zhang	PROPN
admet-2756	329	28	,	,	PUNCT
admet-2756	329	29	x.	x.	PROPN
admet-2756	329	30	lin	lin	PROPN
admet-2756	329	31	,	,	PUNCT
admet-2756	329	32	x.	x.	PROPN
admet-2756	329	33	,	,	PUNCT
admet-2756	329	34	zhou	zhou	PROPN
admet-2756	329	35	,	,	PUNCT
admet-2756	329	36	b.f	b.f	PROPN
admet-2756	329	37	.	.	PROPN
admet-2756	329	38	boyce	boyce	PROPN
admet-2756	329	39	,	,	PUNCT
admet-2756	329	40	p.w	p.w	PROPN
admet-2756	329	41	.	.	PROPN
admet-2756	329	42	villalta	villalta	PROPN
admet-2756	329	43	,	,	PUNCT
admet-2756	329	44	f.h	f.h	PROPN
admet-2756	329	45	.	.	PROPN
admet-2756	329	46	ebetino	ebetino	PROPN
admet-2756	329	47	,	,	PUNCT
admet-2756	329	48	k.k	k.k	PROPN
admet-2756	329	49	.	.	PROPN
admet-2756	329	50	ho	ho	PROPN
admet-2756	329	51	.	.	PUNCT
admet-2756	329	52	bone	bone	NOUN
admet-2756	329	53	-	-	PUNCT
admet-2756	329	54	targeted	target	VERB
admet-2756	329	55	bortezomib	bortezomib	NOUN
admet-2756	329	56	inhibits	inhibit	VERB
admet-2756	329	57	bortezomib	bortezomib	NOUN
admet-2756	329	58	-	-	PUNCT
admet-2756	329	59	resistant	resistant	ADJ
admet-2756	329	60	multiple	multiple	ADJ
admet-2756	329	61	myeloma	myeloma	NOUN
admet-2756	329	62	in	in	ADP
admet-2756	329	63	mice	mouse	NOUN
admet-2756	329	64	by	by	ADP
admet-2756	329	65	providing	provide	VERB
admet-2756	329	66	higher	high	ADJ
admet-2756	329	67	levels	level	NOUN
admet-2756	329	68	of	of	ADP
admet-2756	329	69	bortezomib	bortezomib	NOUN
admet-2756	329	70	in	in	ADP
admet-2756	329	71	bone	bone	PROPN
admet-2756	329	72	.	.	PUNCT
admet-2756	330	1	journal	journal	PROPN
admet-2756	330	2	of	of	ADP
admet-2756	330	3	bone	bone	NOUN
admet-2756	330	4	and	and	CCONJ
admet-2756	330	5	mineral	mineral	NOUN
admet-2756	330	6	research	research	NOUN
admet-2756	330	7	37	37	NUM
admet-2756	330	8	(	(	PUNCT
admet-2756	330	9	2022	2022	NUM
admet-2756	330	10	)	)	PUNCT
admet-2756	330	11	629642	629642	NUM
admet-2756	330	12	https://doi.org/10.1002/jbmr.4496	https://doi.org/10.1002/jbmr.4496	NOUN
admet-2756	330	13	[	[	X
admet-2756	330	14	25	25	NUM
admet-2756	330	15	]	]	X
admet-2756	330	16	s.j	s.j	PROPN
admet-2756	330	17	.	.	PROPN
admet-2756	330	18	jang	jang	PROPN
admet-2756	330	19	,	,	PUNCT
admet-2756	330	20	s.e	s.e	PROPN
admet-2756	330	21	.	.	PROPN
admet-2756	330	22	kim	kim	PROPN
admet-2756	330	23	,	,	PUNCT
admet-2756	330	24	t.s	t.s	PROPN
admet-2756	330	25	.	.	PROPN
admet-2756	330	26	han	han	PROPN
admet-2756	330	27	,	,	PUNCT
admet-2756	330	28	j.s	j.s	PROPN
admet-2756	330	29	.	.	PROPN
admet-2756	330	30	son	son	PROPN
admet-2756	330	31	,	,	PUNCT
admet-2756	330	32	s.s	s.s	PROPN
admet-2756	330	33	.	.	PROPN
admet-2756	330	34	,	,	PUNCT
admet-2756	330	35	kang	kang	PROPN
admet-2756	330	36	,	,	PUNCT
admet-2756	330	37	s.h	s.h	PROPN
admet-2756	330	38	.	.	PROPN
admet-2756	330	39	choi	choi	NOUN
admet-2756	330	40	.	.	PUNCT
admet-2756	331	1	bone	bone	NOUN
admet-2756	331	2	regeneration	regeneration	NOUN
admet-2756	331	3	of	of	ADP
admet-2756	331	4	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	331	5	with	with	ADP
admet-2756	331	6	granular	granular	ADJ
admet-2756	331	7	form	form	NOUN
admet-2756	331	8	or	or	CCONJ
admet-2756	331	9	porous	porous	ADJ
admet-2756	331	10	scaffold	scaffold	NOUN
admet-2756	331	11	in	in	ADP
admet-2756	331	12	canine	canine	NOUN
admet-2756	331	13	alveolar	alveolar	ADJ
admet-2756	331	14	sockets	socket	NOUN
admet-2756	331	15	.	.	PUNCT
admet-2756	332	1	in	in	ADP
admet-2756	332	2	vivo	vivo	NOUN
admet-2756	332	3	31	31	NUM
admet-2756	332	4	(	(	PUNCT
admet-2756	332	5	2017	2017	NUM
admet-2756	332	6	)	)	PUNCT
admet-2756	332	7	335	335	NUM
admet-2756	332	8	-	-	SYM
admet-2756	332	9	341	341	NUM
admet-2756	332	10	https://doi.org/10.21873/invivo.11064	https://doi.org/10.21873/invivo.11064	NOUN
admet-2756	332	11	[	[	X
admet-2756	332	12	26	26	NUM
admet-2756	332	13	]	]	PUNCT
admet-2756	332	14	j.	j.	PROPN
admet-2756	332	15	jeong	jeong	PROPN
admet-2756	332	16	,	,	PUNCT
admet-2756	332	17	j.h	j.h	PROPN
admet-2756	332	18	.	.	PROPN
admet-2756	332	19	kim	kim	PROPN
admet-2756	332	20	,	,	PUNCT
admet-2756	332	21	j.h	j.h	PROPN
admet-2756	332	22	.	.	PROPN
admet-2756	332	23	,	,	PUNCT
admet-2756	332	24	shim	shim	NOUN
admet-2756	332	25	,	,	PUNCT
admet-2756	332	26	n.s	n.s	PROPN
admet-2756	332	27	.	.	PROPN
admet-2756	332	28	hwang	hwang	PROPN
admet-2756	332	29	,	,	PUNCT
admet-2756	332	30	c.y	c.y	PROPN
admet-2756	332	31	.	.	PROPN
admet-2756	332	32	heo	heo	PROPN
admet-2756	332	33	.	.	PROPN
admet-2756	332	34	bioactive	bioactive	PROPN
admet-2756	332	35	calcium	calcium	NOUN
admet-2756	332	36	phosphate	phosphate	NOUN
admet-2756	332	37	materials	material	NOUN
admet-2756	332	38	and	and	CCONJ
admet-2756	332	39	applications	application	NOUN
admet-2756	332	40	in	in	ADP
admet-2756	332	41	bone	bone	NOUN
admet-2756	332	42	regeneration	regeneration	NOUN
admet-2756	332	43	.	.	PUNCT
admet-2756	333	1	biomaterials	biomaterial	NOUN
admet-2756	333	2	research	research	VERB
admet-2756	333	3	23	23	NUM
admet-2756	333	4	(	(	PUNCT
admet-2756	333	5	2019	2019	NUM
admet-2756	333	6	)	)	PUNCT
admet-2756	333	7	1	1	NUM
admet-2756	333	8	-	-	SYM
admet-2756	333	9	11	11	NUM
admet-2756	333	10	https://doi.org/10.1186/s40824-018-0149-3	https://doi.org/10.1186/s40824-018-0149-3	NUM
admet-2756	333	11	[	[	X
admet-2756	333	12	27	27	NUM
admet-2756	333	13	]	]	X
admet-2756	333	14	n.	n.	PROPN
admet-2756	333	15	pajares	pajare	NOUN
admet-2756	333	16	-	-	PUNCT
admet-2756	333	17	chamorro	chamorro	ADJ
admet-2756	333	18	,	,	PUNCT
admet-2756	333	19	x.	x.	PROPN
admet-2756	333	20	chatzistavrou	chatzistavrou	PROPN
admet-2756	333	21	.	.	PROPN
admet-2756	334	1	bioactive	bioactive	PROPN
admet-2756	334	2	glass	glass	NOUN
admet-2756	334	3	nanoparticles	nanoparticle	NOUN
admet-2756	334	4	for	for	ADP
admet-2756	334	5	tissue	tissue	NOUN
admet-2756	334	6	regeneration	regeneration	NOUN
admet-2756	334	7	.	.	PUNCT
admet-2756	335	1	acs	acs	PROPN
admet-2756	335	2	omega	omega	NOUN
admet-2756	335	3	5	5	NUM
admet-2756	335	4	(	(	PUNCT
admet-2756	335	5	2020	2020	NUM
admet-2756	335	6	)	)	PUNCT
admet-2756	335	7	12716	12716	NUM
admet-2756	335	8	-	-	SYM
admet-2756	335	9	12726	12726	NUM
admet-2756	335	10	https://doi.org/10.1021/acsomega.0c00180	https://doi.org/10.1021/acsomega.0c00180	NOUN
admet-2756	335	11	[	[	X
admet-2756	335	12	28	28	NUM
admet-2756	335	13	]	]	X
admet-2756	335	14	d.	d.	PROPN
admet-2756	335	15	li	li	PROPN
admet-2756	335	16	,	,	PUNCT
admet-2756	335	17	y.	y.	PROPN
admet-2756	335	18	zhu	zhu	PROPN
admet-2756	335	19	,	,	PUNCT
admet-2756	335	20	z.	z.	PROPN
admet-2756	335	21	liang	liang	PROPN
admet-2756	335	22	.	.	PUNCT
admet-2756	336	1	alendronate	alendronate	PROPN
admet-2756	336	2	functionalized	functionalize	VERB
admet-2756	336	3	mesoporous	mesoporous	ADJ
admet-2756	336	4	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	336	5	nanoparticles	nanoparticle	NOUN
admet-2756	336	6	for	for	ADP
admet-2756	336	7	drug	drug	NOUN
admet-2756	336	8	delivery	delivery	NOUN
admet-2756	336	9	.	.	PUNCT
admet-2756	337	1	materials	material	NOUN
admet-2756	337	2	research	research	NOUN
admet-2756	337	3	bulletin	bulletin	NOUN
admet-2756	337	4	48	48	NUM
admet-2756	337	5	(	(	PUNCT
admet-2756	337	6	2013	2013	NUM
admet-2756	337	7	)	)	PUNCT
admet-2756	337	8	2201	2201	NUM
admet-2756	337	9	-	-	SYM
admet-2756	337	10	2204	2204	NUM
admet-2756	337	11	https://doi.org/10.1016/j.materresbull.2013.02.049	https://doi.org/10.1016/j.materresbull.2013.02.049	NOUN
admet-2756	337	12	[	[	X
admet-2756	337	13	29	29	NUM
admet-2756	337	14	]	]	X
admet-2756	337	15	w.	w.	PROPN
admet-2756	337	16	chu	chu	PROPN
admet-2756	337	17	,	,	PUNCT
admet-2756	337	18	y.	y.	PROPN
admet-2756	337	19	huang	huang	PROPN
admet-2756	337	20	,	,	PUNCT
admet-2756	337	21	c.	c.	PROPN
admet-2756	337	22	yang	yang	PROPN
admet-2756	337	23	,	,	PUNCT
admet-2756	337	24	y.	y.	PROPN
admet-2756	337	25	liao	liao	PROPN
admet-2756	337	26	,	,	PUNCT
admet-2756	337	27	x.	x.	PROPN
admet-2756	337	28	zhang	zhang	PROPN
admet-2756	337	29	,	,	PUNCT
admet-2756	337	30	m.	m.	PROPN
admet-2756	337	31	yan	yan	PROPN
admet-2756	337	32	,	,	PUNCT
admet-2756	337	33	s.	s.	PROPN
admet-2756	337	34	cui	cui	PROPN
admet-2756	337	35	,	,	PUNCT
admet-2756	337	36	c.	c.	PROPN
admet-2756	337	37	zhao	zhao	PROPN
admet-2756	337	38	.	.	PUNCT
admet-2756	338	1	calcium	calcium	NOUN
admet-2756	338	2	phosphate	phosphate	NOUN
admet-2756	338	3	nanoparticles	nanoparticle	NOUN
admet-2756	338	4	functionalized	functionalize	VERB
admet-2756	338	5	with	with	ADP
admet-2756	338	6	alendronate	alendronate	ADV
admet-2756	338	7	-	-	PUNCT
admet-2756	338	8	conjugated	conjugate	VERB
admet-2756	338	9	polyethylene	polyethylene	NOUN
admet-2756	338	10	glycol	glycol	NOUN
admet-2756	338	11	(	(	PUNCT
admet-2756	338	12	peg	peg	NOUN
admet-2756	338	13	)	)	PUNCT
admet-2756	338	14	for	for	ADP
admet-2756	338	15	the	the	DET
admet-2756	338	16	treatment	treatment	NOUN
admet-2756	338	17	of	of	ADP
admet-2756	338	18	bone	bone	NOUN
admet-2756	338	19	metastasis	metastasis	NOUN
admet-2756	338	20	.	.	PUNCT
admet-2756	339	1	international	international	ADJ
admet-2756	339	2	journal	journal	PROPN
admet-2756	339	3	of	of	ADP
admet-2756	339	4	pharmaceutics	pharmaceutic	NOUN
admet-2756	339	5	516	516	NUM
admet-2756	339	6	(	(	PUNCT
admet-2756	339	7	2017	2017	NUM
admet-2756	339	8	)	)	PUNCT
admet-2756	339	9	352	352	NUM
admet-2756	339	10	-	-	SYM
admet-2756	339	11	363	363	NUM
admet-2756	339	12	https://doi.org/10.1016/j.ijpharm.2016.11.051	https://doi.org/10.1016/j.ijpharm.2016.11.051	NOUN
admet-2756	339	13	[	[	X
admet-2756	339	14	30	30	NUM
admet-2756	339	15	]	]	PUNCT
admet-2756	339	16	s.	s.	PROPN
admet-2756	339	17	mehnath	mehnath	PROPN
admet-2756	339	18	,	,	PUNCT
admet-2756	339	19	k.	k.	PROPN
admet-2756	339	20	karthikeyan	karthikeyan	PROPN
admet-2756	339	21	,	,	PUNCT
admet-2756	339	22	m.	m.	PROPN
admet-2756	339	23	rajan	rajan	PROPN
admet-2756	339	24	,	,	PUNCT
admet-2756	339	25	m.	m.	NOUN
admet-2756	339	26	jeyaraj	jeyaraj	PROPN
admet-2756	339	27	.	.	PUNCT
admet-2756	340	1	fabrication	fabrication	NOUN
admet-2756	340	2	of	of	ADP
admet-2756	340	3	bone	bone	NOUN
admet-2756	340	4	-	-	PUNCT
admet-2756	340	5	targeting	target	VERB
admet-2756	340	6	hyaluronic	hyaluronic	ADJ
admet-2756	340	7	acid	acid	NOUN
admet-2756	340	8	coupled	couple	VERB
admet-2756	340	9	alendronate	alendronate	ADJ
admet-2756	340	10	-	-	PUNCT
admet-2756	340	11	bioactive	bioactive	NOUN
admet-2756	340	12	glass	glass	NOUN
admet-2756	340	13	for	for	ADP
admet-2756	340	14	osteosarcoma	osteosarcoma	ADJ
admet-2756	340	15	therapy	therapy	NOUN
admet-2756	340	16	.	.	PUNCT
admet-2756	341	1	materials	material	NOUN
admet-2756	341	2	chemistry	chemistry	NOUN
admet-2756	341	3	and	and	CCONJ
admet-2756	341	4	physics	physics	NOUN
admet-2756	341	5	273	273	NUM
admet-2756	341	6	(	(	PUNCT
admet-2756	341	7	2021	2021	NUM
admet-2756	341	8	)	)	PUNCT
admet-2756	341	9	125146	125146	NUM
admet-2756	341	10	https://doi.org/10.1016/j.matchemphys.2021.125146	https://doi.org/10.1016/j.matchemphys.2021.125146	PROPN
admet-2756	342	1	[	[	X
admet-2756	342	2	31	31	NUM
admet-2756	342	3	]	]	X
admet-2756	342	4	y.	y.	PROPN
admet-2756	342	5	lin	lin	PROPN
admet-2756	342	6	,	,	PUNCT
admet-2756	342	7	m.g	m.g	PROPN
admet-2756	342	8	.	.	PROPN
admet-2756	342	9	villacanas	villacanas	PROPN
admet-2756	342	10	,	,	PUNCT
admet-2756	342	11	h.	h.	PROPN
admet-2756	342	12	,	,	PUNCT
admet-2756	342	13	zou	zou	PROPN
admet-2756	342	14	,	,	PUNCT
admet-2756	342	15	h.	h.	PROPN
admet-2756	342	16	liu	liu	PROPN
admet-2756	342	17	,	,	PUNCT
admet-2756	342	18	i.g	i.g	PROPN
admet-2756	342	19	.	.	PROPN
admet-2756	342	20	carcedo	carcedo	PROPN
admet-2756	342	21	,	,	PUNCT
admet-2756	342	22	y.	y.	PROPN
admet-2756	342	23	wu	wu	PROPN
admet-2756	342	24	,	,	PUNCT
admet-2756	342	25	b.	b.	PROPN
admet-2756	342	26	sun	sun	PROPN
admet-2756	342	27	,	,	PUNCT
admet-2756	342	28	x.	x.	PROPN
admet-2756	342	29	wu	wu	PROPN
admet-2756	342	30	,	,	PUNCT
admet-2756	342	31	i.	i.	NOUN
admet-2756	342	32	prasadam	prasadam	PROPN
admet-2756	342	33	,	,	PUNCT
admet-2756	342	34	m.j	m.j	PROPN
admet-2756	342	35	.	.	PROPN
admet-2756	342	36	monteiro	monteiro	PROPN
admet-2756	342	37	,	,	PUNCT
admet-2756	342	38	l.	l.	PROPN
admet-2756	342	39	li	li	PROPN
admet-2756	342	40	.	.	PROPN
admet-2756	342	41	calcium	calcium	NOUN
admet-2756	342	42	-	-	PUNCT
admet-2756	342	43	bisphosphonate	bisphosphonate	NOUN
admet-2756	342	44	nanoparticle	nanoparticle	NOUN
admet-2756	342	45	platform	platform	NOUN
admet-2756	342	46	as	as	ADP
admet-2756	342	47	a	a	DET
admet-2756	342	48	prolonged	prolonged	ADJ
admet-2756	342	49	nanodrug	nanodrug	NOUN
admet-2756	342	50	and	and	CCONJ
admet-2756	342	51	bone	bone	NOUN
admet-2756	342	52	-	-	PUNCT
admet-2756	342	53	targeted	target	VERB
admet-2756	342	54	delivery	delivery	NOUN
admet-2756	342	55	system	system	NOUN
admet-2756	342	56	for	for	ADP
admet-2756	342	57	bone	bone	NOUN
admet-2756	342	58	diseases	disease	NOUN
admet-2756	342	59	and	and	CCONJ
admet-2756	342	60	cancers	cancer	NOUN
admet-2756	342	61	.	.	PUNCT
admet-2756	343	1	acs	acs	PROPN
admet-2756	343	2	applied	apply	VERB
admet-2756	343	3	bio	bio	NOUN
admet-2756	343	4	materials	material	NOUN
admet-2756	343	5	4	4	NUM
admet-2756	343	6	(	(	PUNCT
admet-2756	343	7	2021	2021	NUM
admet-2756	343	8	)	)	PUNCT
admet-2756	343	9	2490	2490	NUM
admet-2756	343	10	-	-	SYM
admet-2756	343	11	2501	2501	NUM
admet-2756	343	12	https://doi.org/10.1021/acsabm.0c01455	https://doi.org/10.1021/acsabm.0c01455	NOUN
admet-2756	343	13	https://doi.org/10.1016/j.mtbio.2020.100088	https://doi.org/10.1016/j.mtbio.2020.100088	PROPN
admet-2756	343	14	https://doi.org/10.1016/j.ica.2017.12.015	https://doi.org/10.1016/j.ica.2017.12.015	PROPN
admet-2756	343	15	https://doi.org/10.1186/s11671-024-04126-1	https://doi.org/10.1186/s11671-024-04126-1	NUM
admet-2756	343	16	https://doi.org/10.1002/jbmr.3012	https://doi.org/10.1002/jbmr.3012	NOUN
admet-2756	343	17	https://doi.org/10.1002/jps.24476	https://doi.org/10.1002/jps.24476	DET
admet-2756	343	18	https://doi.org/10.1016/j.jinorgbio.2018.11.010	https://doi.org/10.1016/j.jinorgbio.2018.11.010	ADJ
admet-2756	343	19	https://doi.org/10.1021/acs.bioconjchem.9b00210	https://doi.org/10.1021/acs.bioconjchem.9b00210	VERB
admet-2756	343	20	https://doi.org/10.1002/jbmr.4496	https://doi.org/10.1002/jbmr.4496	NOUN
admet-2756	343	21	https://doi.org/10.21873/invivo.11064	https://doi.org/10.21873/invivo.11064	NOUN
admet-2756	343	22	https://doi.org/10.1186/s40824-018-0149-3	https://doi.org/10.1186/s40824-018-0149-3	PROPN
admet-2756	343	23	https://doi.org/10.1021/acsomega.0c00180	https://doi.org/10.1021/acsomega.0c00180	PROPN
admet-2756	344	1	https://doi.org/10.1016/j.materresbull.2013.02.049	https://doi.org/10.1016/j.materresbull.2013.02.049	PROPN
admet-2756	344	2	https://doi.org/10.1016/j.ijpharm.2016.11.051	https://doi.org/10.1016/j.ijpharm.2016.11.051	VERB
admet-2756	344	3	https://doi.org/10.1016/j.matchemphys.2021.125146	https://doi.org/10.1016/j.matchemphys.2021.125146	PROPN
admet-2756	344	4	https://doi.org/10.1021/acsabm.0c01455	https://doi.org/10.1021/acsabm.0c01455	PROPN
admet-2756	344	5	admet	admet	PROPN
admet-2756	344	6	&	&	CCONJ
admet-2756	344	7	dmpk	dmpk	PROPN
admet-2756	344	8	13(3	13(3	NUM
admet-2756	344	9	)	)	PUNCT
admet-2756	344	10	(	(	PUNCT
admet-2756	344	11	2025	2025	NUM
admet-2756	344	12	)	)	PUNCT
admet-2756	344	13	2756	2756	NUM
admet-2756	344	14	bisphosphonates	bisphosphonate	NOUN
admet-2756	344	15	for	for	ADP
admet-2756	344	16	bone	bone	NOUN
admet-2756	344	17	cancer	cancer	NOUN
admet-2756	344	18	therapy	therapy	NOUN
admet-2756	344	19	doi	doi	NOUN
admet-2756	344	20	:	:	PUNCT
admet-2756	344	21	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	344	22	15	15	NUM
admet-2756	344	23	[	[	X
admet-2756	344	24	32	32	NUM
admet-2756	344	25	]	]	SYM
admet-2756	344	26	v.m	v.m	PROPN
admet-2756	344	27	.	.	PROPN
admet-2756	344	28	wu	wu	PROPN
admet-2756	344	29	,	,	PUNCT
admet-2756	344	30	j.	j.	PROPN
admet-2756	344	31	mickens	mickens	PROPN
admet-2756	344	32	,	,	PUNCT
admet-2756	344	33	v.	v.	ADP
admet-2756	344	34	uskokovic	uskokovic	PROPN
admet-2756	344	35	.	.	PUNCT
admet-2756	345	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	345	2	-	-	PUNCT
admet-2756	345	3	functionalized	functionalize	VERB
admet-2756	345	4	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	345	5	nanoparticles	nanoparticle	NOUN
admet-2756	345	6	for	for	ADP
admet-2756	345	7	the	the	DET
admet-2756	345	8	delivery	delivery	NOUN
admet-2756	345	9	of	of	ADP
admet-2756	345	10	the	the	DET
admet-2756	345	11	bromodomain	bromodomain	NOUN
admet-2756	345	12	inhibitor	inhibitor	NOUN
admet-2756	345	13	jq1	jq1	NOUN
admet-2756	345	14	in	in	ADP
admet-2756	345	15	the	the	DET
admet-2756	345	16	treatment	treatment	NOUN
admet-2756	345	17	of	of	ADP
admet-2756	345	18	osteosarcoma	osteosarcoma	NOUN
admet-2756	345	19	.	.	PUNCT
admet-2756	346	1	acs	acs	PROPN
admet-2756	346	2	applied	apply	VERB
admet-2756	346	3	materials	material	NOUN
admet-2756	346	4	&	&	CCONJ
admet-2756	346	5	interfaces	interface	NOUN
admet-2756	346	6	9	9	NUM
admet-2756	346	7	(	(	PUNCT
admet-2756	346	8	2017	2017	NUM
admet-2756	346	9	)	)	PUNCT
admet-2756	346	10	25887	25887	NUM
admet-2756	346	11	-	-	SYM
admet-2756	346	12	25904	25904	NUM
admet-2756	346	13	https://doi.org/10.1021/acsami.7b08108	https://doi.org/10.1021/acsami.7b08108	PROPN
admet-2756	347	1	[	[	X
admet-2756	347	2	33	33	NUM
admet-2756	347	3	]	]	X
admet-2756	347	4	t.t	t.t	PROPN
admet-2756	347	5	.	.	PROPN
admet-2756	347	6	pham	pham	PROPN
admet-2756	347	7	,	,	PUNCT
admet-2756	347	8	h.t	h.t	PROPN
admet-2756	347	9	.	.	PROPN
admet-2756	347	10	nguyen	nguyen	PROPN
admet-2756	347	11	,	,	PUNCT
admet-2756	347	12	c.	c.	PROPN
admet-2756	347	13	dai	dai	PROPN
admet-2756	347	14	phung	phung	PROPN
admet-2756	347	15	,	,	PUNCT
admet-2756	347	16	s.	s.	PROPN
admet-2756	347	17	pathak	pathak	PROPN
admet-2756	347	18	,	,	PUNCT
admet-2756	347	19	s.	s.	PROPN
admet-2756	347	20	regmi	regmi	PROPN
admet-2756	347	21	,	,	PUNCT
admet-2756	347	22	d.h	d.h	PROPN
admet-2756	347	23	.	.	PROPN
admet-2756	348	1	ha	ha	PROPN
admet-2756	348	2	,	,	PUNCT
admet-2756	348	3	j.o	j.o	PROPN
admet-2756	348	4	.	.	PROPN
admet-2756	348	5	kim	kim	PROPN
admet-2756	348	6	,	,	PUNCT
admet-2756	348	7	c.s	c.s	PROPN
admet-2756	348	8	.	.	PROPN
admet-2756	348	9	yong	yong	PROPN
admet-2756	348	10	,	,	PUNCT
admet-2756	348	11	s.k	s.k	PROPN
admet-2756	348	12	.	.	PROPN
admet-2756	348	13	kim	kim	PROPN
admet-2756	348	14	,	,	PUNCT
admet-2756	348	15	j.e	j.e	PROPN
admet-2756	348	16	.	.	PROPN
admet-2756	348	17	choi	choi	PROPN
admet-2756	348	18	,	,	PUNCT
admet-2756	348	19	s.	s.	PROPN
admet-2756	348	20	yook	yook	PROPN
admet-2756	348	21	.	.	PUNCT
admet-2756	349	1	targeted	target	VERB
admet-2756	349	2	delivery	delivery	NOUN
admet-2756	349	3	of	of	ADP
admet-2756	349	4	doxorubicin	doxorubicin	PROPN
admet-2756	349	5	for	for	ADP
admet-2756	349	6	the	the	DET
admet-2756	349	7	treatment	treatment	NOUN
admet-2756	349	8	of	of	ADP
admet-2756	349	9	bone	bone	NOUN
admet-2756	349	10	metastasis	metastasis	NOUN
admet-2756	349	11	from	from	ADP
admet-2756	349	12	breast	breast	NOUN
admet-2756	349	13	cancer	cancer	NOUN
admet-2756	349	14	using	use	VERB
admet-2756	349	15	alendronate	alendronate	NOUN
admet-2756	349	16	-	-	PUNCT
admet-2756	349	17	functionalized	functionalize	VERB
admet-2756	349	18	graphene	graphene	NOUN
admet-2756	349	19	oxide	oxide	NOUN
admet-2756	349	20	nanosheets	nanosheet	NOUN
admet-2756	349	21	.	.	PUNCT
admet-2756	350	1	journal	journal	PROPN
admet-2756	350	2	of	of	ADP
admet-2756	350	3	industrial	industrial	ADJ
admet-2756	350	4	and	and	CCONJ
admet-2756	350	5	engineering	engineering	NOUN
admet-2756	350	6	chemistry	chemistry	NOUN
admet-2756	350	7	76	76	NUM
admet-2756	350	8	(	(	PUNCT
admet-2756	350	9	2019	2019	NUM
admet-2756	350	10	)	)	PUNCT
admet-2756	350	11	310	310	NUM
admet-2756	350	12	-	-	SYM
admet-2756	350	13	317	317	NUM
admet-2756	350	14	https://doi.org/10.1016/j.jiec.2019.03.055	https://doi.org/10.1016/j.jiec.2019.03.055	ADV
admet-2756	350	15	[	[	X
admet-2756	350	16	34	34	NUM
admet-2756	350	17	]	]	PUNCT
admet-2756	350	18	m.	m.	NOUN
admet-2756	350	19	sato	sato	PROPN
admet-2756	350	20	,	,	PUNCT
admet-2756	350	21	w.	w.	PROPN
admet-2756	350	22	grasser	grasser	PROPN
admet-2756	350	23	,	,	PUNCT
admet-2756	350	24	n.	n.	PROPN
admet-2756	350	25	endo	endo	PROPN
admet-2756	350	26	,	,	PUNCT
admet-2756	350	27	r.	r.	PROPN
admet-2756	350	28	akins	akins	PROPN
admet-2756	350	29	,	,	PUNCT
admet-2756	350	30	h.	h.	PROPN
admet-2756	350	31	simmons	simmons	PROPN
admet-2756	350	32	,	,	PUNCT
admet-2756	350	33	d.d	d.d	PROPN
admet-2756	350	34	.	.	PROPN
admet-2756	350	35	thompson	thompson	PROPN
admet-2756	350	36	,	,	PUNCT
admet-2756	350	37	e.	e.	PROPN
admet-2756	350	38	golub	golub	PROPN
admet-2756	350	39	,	,	PUNCT
admet-2756	350	40	g.a	g.a	PROPN
admet-2756	350	41	.	.	PROPN
admet-2756	350	42	rodan	rodan	PROPN
admet-2756	350	43	.	.	PROPN
admet-2756	350	44	bisphosphonate	bisphosphonate	PROPN
admet-2756	350	45	action	action	NOUN
admet-2756	350	46	.	.	PUNCT
admet-2756	351	1	alendronate	alendronate	PROPN
admet-2756	351	2	localization	localization	NOUN
admet-2756	351	3	in	in	ADP
admet-2756	351	4	rat	rat	NOUN
admet-2756	351	5	bone	bone	NOUN
admet-2756	351	6	and	and	CCONJ
admet-2756	351	7	effects	effect	NOUN
admet-2756	351	8	on	on	ADP
admet-2756	351	9	osteoclast	osteoclast	ADJ
admet-2756	351	10	ultrastructure	ultrastructure	NOUN
admet-2756	351	11	.	.	PUNCT
admet-2756	352	1	the	the	DET
admet-2756	352	2	journal	journal	NOUN
admet-2756	352	3	of	of	ADP
admet-2756	352	4	clinical	clinical	ADJ
admet-2756	352	5	investigation	investigation	NOUN
admet-2756	352	6	88	88	NUM
admet-2756	352	7	(	(	PUNCT
admet-2756	352	8	1991	1991	NUM
admet-2756	352	9	)	)	PUNCT
admet-2756	352	10	2095	2095	NUM
admet-2756	352	11	-	-	SYM
admet-2756	352	12	2105	2105	NUM
admet-2756	352	13	https://doi.org/10.1172/jci115539	https://doi.org/10.1172/jci115539	NOUN
admet-2756	352	14	[	[	X
admet-2756	352	15	35	35	NUM
admet-2756	352	16	]	]	X
admet-2756	352	17	k.r	k.r	PROPN
admet-2756	352	18	.	.	PROPN
admet-2756	352	19	chaudhari	chaudhari	PROPN
admet-2756	352	20	,	,	PUNCT
admet-2756	352	21	a.	a.	PROPN
admet-2756	352	22	kumar	kumar	PROPN
admet-2756	352	23	,	,	PUNCT
admet-2756	352	24	v.k.m	v.k.m	PROPN
admet-2756	352	25	.	.	PROPN
admet-2756	352	26	khandelwal	khandelwal	PROPN
admet-2756	352	27	,	,	PUNCT
admet-2756	352	28	m.	m.	NOUN
admet-2756	352	29	ukawala	ukawala	PROPN
admet-2756	352	30	,	,	PUNCT
admet-2756	352	31	a.s	a.s	PROPN
admet-2756	352	32	.	.	PROPN
admet-2756	352	33	manjappa	manjappa	PROPN
admet-2756	352	34	,	,	PUNCT
admet-2756	352	35	a.k	a.k	PROPN
admet-2756	352	36	.	.	PROPN
admet-2756	352	37	mishra	mishra	PROPN
admet-2756	352	38	,	,	PUNCT
admet-2756	352	39	j.	j.	PROPN
admet-2756	352	40	monkkonen	monkkonen	PROPN
admet-2756	352	41	,	,	PUNCT
admet-2756	352	42	r.s.r	r.s.r	NOUN
admet-2756	352	43	.	.	PUNCT
admet-2756	352	44	murthy	murthy	PROPN
admet-2756	352	45	.	.	PUNCT
admet-2756	353	1	bone	bone	NOUN
admet-2756	353	2	metastasis	metastasis	NOUN
admet-2756	353	3	targeting	target	VERB
admet-2756	353	4	:	:	PUNCT
admet-2756	353	5	a	a	DET
admet-2756	353	6	novel	novel	ADJ
admet-2756	353	7	approach	approach	NOUN
admet-2756	353	8	to	to	PART
admet-2756	353	9	reach	reach	VERB
admet-2756	353	10	bone	bone	NOUN
admet-2756	353	11	using	use	VERB
admet-2756	353	12	zoledronate	zoledronate	ADJ
admet-2756	353	13	anchored	anchor	VERB
admet-2756	353	14	plga	plga	NOUN
admet-2756	353	15	nanoparticle	nanoparticle	NOUN
admet-2756	353	16	as	as	ADP
admet-2756	353	17	carrier	carrier	NOUN
admet-2756	353	18	system	system	NOUN
admet-2756	353	19	loaded	load	VERB
admet-2756	353	20	with	with	ADP
admet-2756	353	21	docetaxel	docetaxel	PROPN
admet-2756	353	22	.	.	PUNCT
admet-2756	354	1	journal	journal	PROPN
admet-2756	354	2	of	of	ADP
admet-2756	354	3	controlled	control	VERB
admet-2756	354	4	release	release	NOUN
admet-2756	354	5	158	158	NUM
admet-2756	354	6	(	(	PUNCT
admet-2756	354	7	2012	2012	NUM
admet-2756	354	8	)	)	PUNCT
admet-2756	354	9	470	470	NUM
admet-2756	354	10	-	-	SYM
admet-2756	354	11	478	478	NUM
admet-2756	354	12	https://doi.org/10.1016/j.jconrel.2011.11.020	https://doi.org/10.1016/j.jconrel.2011.11.020	NOUN
admet-2756	354	13	[	[	PUNCT
admet-2756	354	14	36	36	NUM
admet-2756	354	15	]	]	X
admet-2756	354	16	e.	e.	PROPN
admet-2756	354	17	lee	lee	PROPN
admet-2756	354	18	,	,	PUNCT
admet-2756	354	19	j.	j.	PROPN
admet-2756	354	20	park	park	PROPN
admet-2756	354	21	,	,	PUNCT
admet-2756	354	22	y.s	y.s	PROPN
admet-2756	354	23	.	.	PROPN
admet-2756	354	24	youn	youn	PROPN
admet-2756	354	25	,	,	PUNCT
admet-2756	354	26	k.t	k.t	PROPN
admet-2756	354	27	.	.	PROPN
admet-2756	355	1	oh	oh	INTJ
admet-2756	355	2	,	,	PUNCT
admet-2756	355	3	d.	d.	PROPN
admet-2756	355	4	kim	kim	PROPN
admet-2756	355	5	,	,	PUNCT
admet-2756	355	6	e.s	e.s	PROPN
admet-2756	355	7	.	.	PROPN
admet-2756	355	8	lee	lee	PROPN
admet-2756	355	9	.	.	PROPN
admet-2756	355	10	alendronate	alendronate	PROPN
admet-2756	355	11	/	/	SYM
admet-2756	355	12	crgd	crgd	NOUN
admet-2756	355	13	-	-	PUNCT
admet-2756	355	14	decorated	decorate	VERB
admet-2756	355	15	ultrafine	ultrafine	NOUN
admet-2756	355	16	hyaluronate	hyaluronate	NOUN
admet-2756	355	17	dot	dot	NOUN
admet-2756	355	18	targeting	target	VERB
admet-2756	355	19	bone	bone	NOUN
admet-2756	355	20	metastasis	metastasis	NOUN
admet-2756	355	21	.	.	PUNCT
admet-2756	356	1	biomedicines	biomedicine	VERB
admet-2756	356	2	8	8	NUM
admet-2756	356	3	(	(	PUNCT
admet-2756	356	4	2020	2020	NUM
admet-2756	356	5	)	)	PUNCT
admet-2756	356	6	492	492	NUM
admet-2756	356	7	https://doi.org/10.3390/biomedicines8110492	https://doi.org/10.3390/biomedicines8110492	NOUN
admet-2756	357	1	[	[	X
admet-2756	357	2	37	37	NUM
admet-2756	357	3	]	]	X
admet-2756	357	4	w.f	w.f	PROPN
admet-2756	357	5	.	.	PROPN
admet-2756	357	6	bleam	bleam	PROPN
admet-2756	357	7	.	.	PUNCT
admet-2756	358	1	chapter	chapter	NOUN
admet-2756	358	2	6	6	NUM
admet-2756	358	3	natural	natural	ADJ
admet-2756	358	4	organic	organic	ADJ
admet-2756	358	5	matter	matter	NOUN
admet-2756	358	6	and	and	CCONJ
admet-2756	358	7	humic	humic	ADJ
admet-2756	358	8	colloids	colloid	NOUN
admet-2756	358	9	,	,	PUNCT
admet-2756	358	10	in	in	ADP
admet-2756	358	11	soil	soil	NOUN
admet-2756	358	12	and	and	CCONJ
admet-2756	358	13	environmental	environmental	ADJ
admet-2756	358	14	chemistry	chemistry	NOUN
admet-2756	358	15	,	,	PUNCT
admet-2756	358	16	academic	academic	ADJ
admet-2756	358	17	press	press	NOUN
admet-2756	358	18	:	:	PUNCT
admet-2756	358	19	boston	boston	PROPN
admet-2756	358	20	,	,	PUNCT
admet-2756	358	21	2012	2012	NUM
admet-2756	358	22	,	,	PUNCT
admet-2756	358	23	209	209	NUM
admet-2756	358	24	-	-	SYM
admet-2756	358	25	256	256	NUM
admet-2756	358	26	.	.	PUNCT
admet-2756	359	1	http://dx.doi.org/10.1016/b978-0-12-4157972.00006-6	http://dx.doi.org/10.1016/b978-0-12-4157972.00006-6	PROPN
admet-2756	359	2	[	[	X
admet-2756	359	3	38	38	NUM
admet-2756	359	4	]	]	PUNCT
admet-2756	359	5	m.	m.	NOUN
admet-2756	359	6	ghezzi	ghezzi	NOUN
admet-2756	359	7	,	,	PUNCT
admet-2756	359	8	s.	s.	PROPN
admet-2756	359	9	pescina	pescina	PROPN
admet-2756	359	10	,	,	PUNCT
admet-2756	359	11	c.	c.	PROPN
admet-2756	359	12	padula	padula	NOUN
admet-2756	359	13	,	,	PUNCT
admet-2756	359	14	p.	p.	PROPN
admet-2756	359	15	santi	santi	PROPN
admet-2756	359	16	,	,	PUNCT
admet-2756	359	17	e.	e.	PROPN
admet-2756	359	18	del	del	PROPN
admet-2756	359	19	favero	favero	PROPN
admet-2756	359	20	,	,	PUNCT
admet-2756	359	21	l.	l.	PROPN
admet-2756	359	22	cantù	cantù	PROPN
admet-2756	359	23	,	,	PUNCT
admet-2756	359	24	s.	s.	PROPN
admet-2756	359	25	nicoli	nicoli	PROPN
admet-2756	359	26	.	.	PUNCT
admet-2756	360	1	polymeric	polymeric	ADJ
admet-2756	360	2	micelles	micelle	NOUN
admet-2756	360	3	in	in	ADP
admet-2756	360	4	drug	drug	NOUN
admet-2756	360	5	delivery	delivery	NOUN
admet-2756	360	6	:	:	PUNCT
admet-2756	360	7	an	an	DET
admet-2756	360	8	insight	insight	NOUN
admet-2756	360	9	of	of	ADP
admet-2756	360	10	the	the	DET
admet-2756	360	11	techniques	technique	NOUN
admet-2756	360	12	for	for	ADP
admet-2756	360	13	their	their	PRON
admet-2756	360	14	characterization	characterization	NOUN
admet-2756	360	15	and	and	CCONJ
admet-2756	360	16	assessment	assessment	NOUN
admet-2756	360	17	in	in	ADP
admet-2756	360	18	biorelevant	biorelevant	ADJ
admet-2756	360	19	conditions	condition	NOUN
admet-2756	360	20	.	.	PUNCT
admet-2756	361	1	journal	journal	NOUN
admet-2756	361	2	of	of	ADP
admet-2756	361	3	controlled	control	VERB
admet-2756	361	4	release	release	NOUN
admet-2756	361	5	332	332	NUM
admet-2756	361	6	(	(	PUNCT
admet-2756	361	7	2021	2021	NUM
admet-2756	361	8	)	)	PUNCT
admet-2756	361	9	312	312	NUM
admet-2756	361	10	-	-	SYM
admet-2756	361	11	336	336	NUM
admet-2756	361	12	https://doi.org/10.1016/j.jconrel.2021.02.031	https://doi.org/10.1016/j.jconrel.2021.02.031	NOUN
admet-2756	361	13	[	[	X
admet-2756	361	14	39	39	NUM
admet-2756	361	15	]	]	PUNCT
admet-2756	361	16	a.	a.	NOUN
admet-2756	361	17	akbarzadeh	akbarzadeh	PROPN
admet-2756	361	18	,	,	PUNCT
admet-2756	361	19	r.	r.	PROPN
admet-2756	361	20	rezaei	rezaei	PROPN
admet-2756	361	21	-	-	PUNCT
admet-2756	361	22	sadabady	sadabady	PROPN
admet-2756	361	23	,	,	PUNCT
admet-2756	361	24	s.	s.	PROPN
admet-2756	361	25	davaran	davaran	PROPN
admet-2756	361	26	,	,	PUNCT
admet-2756	361	27	s.w	s.w	PROPN
admet-2756	361	28	.	.	PROPN
admet-2756	361	29	joo	joo	PROPN
admet-2756	361	30	,	,	PUNCT
admet-2756	361	31	n.	n.	PROPN
admet-2756	361	32	zarghami	zarghami	PROPN
admet-2756	361	33	,	,	PUNCT
admet-2756	361	34	y.	y.	PROPN
admet-2756	361	35	hanifehpour	hanifehpour	PROPN
admet-2756	361	36	,	,	PUNCT
admet-2756	361	37	m.	m.	PROPN
admet-2756	361	38	samiei	samiei	PROPN
admet-2756	361	39	,	,	PUNCT
admet-2756	361	40	m.	m.	PROPN
admet-2756	361	41	kouhi	kouhi	PROPN
admet-2756	361	42	,	,	PUNCT
admet-2756	361	43	k.	k.	PROPN
admet-2756	361	44	nejati	nejati	PROPN
admet-2756	361	45	-	-	PUNCT
admet-2756	361	46	koshki	koshki	PROPN
admet-2756	361	47	.	.	PUNCT
admet-2756	362	1	liposome	liposome	NOUN
admet-2756	362	2	:	:	PUNCT
admet-2756	362	3	classification	classification	NOUN
admet-2756	362	4	,	,	PUNCT
admet-2756	362	5	preparation	preparation	NOUN
admet-2756	362	6	and	and	CCONJ
admet-2756	362	7	applications	application	NOUN
admet-2756	362	8	.	.	PUNCT
admet-2756	363	1	nanoscale	nanoscale	NOUN
admet-2756	363	2	research	research	NOUN
admet-2756	363	3	letters	letter	NOUN
admet-2756	363	4	8	8	NUM
admet-2756	363	5	(	(	PUNCT
admet-2756	363	6	2013	2013	NUM
admet-2756	363	7	)	)	PUNCT
admet-2756	363	8	1	1	NUM
admet-2756	363	9	-	-	SYM
admet-2756	363	10	9	9	NUM
admet-2756	363	11	https://doi.org/10.1186/1556-276x-8-102	https://doi.org/10.1186/1556-276x-8-102	NOUN
admet-2756	364	1	[	[	X
admet-2756	364	2	40	40	NUM
admet-2756	364	3	]	]	PUNCT
admet-2756	364	4	j.	j.	PROPN
admet-2756	364	5	shi	shi	PROPN
admet-2756	364	6	,	,	PUNCT
admet-2756	364	7	p.w	p.w	PROPN
admet-2756	364	8	.	.	PROPN
admet-2756	364	9	kantoff	kantoff	PROPN
admet-2756	364	10	,	,	PUNCT
admet-2756	364	11	r.	r.	PROPN
admet-2756	364	12	wooster	wooster	PROPN
admet-2756	364	13	,	,	PUNCT
admet-2756	364	14	o.c	o.c	PROPN
admet-2756	364	15	.	.	PROPN
admet-2756	364	16	farokhzad	farokhzad	PROPN
admet-2756	364	17	.	.	PUNCT
admet-2756	365	1	cancer	cancer	NOUN
admet-2756	365	2	nanomedicine	nanomedicine	NOUN
admet-2756	365	3	:	:	PUNCT
admet-2756	365	4	progress	progress	NOUN
admet-2756	365	5	,	,	PUNCT
admet-2756	365	6	challenges	challenge	NOUN
admet-2756	365	7	and	and	CCONJ
admet-2756	365	8	opportunities	opportunity	NOUN
admet-2756	365	9	.	.	PUNCT
admet-2756	366	1	nature	nature	NOUN
admet-2756	366	2	reviews	review	VERB
admet-2756	366	3	cancer	cancer	NOUN
admet-2756	366	4	17	17	NUM
admet-2756	366	5	(	(	PUNCT
admet-2756	366	6	2017	2017	NUM
admet-2756	366	7	)	)	PUNCT
admet-2756	366	8	20	20	NUM
admet-2756	366	9	-	-	SYM
admet-2756	366	10	37	37	NUM
admet-2756	366	11	https://doi.org/10.1038/nrc.2016.108	https://doi.org/10.1038/nrc.2016.108	NOUN
admet-2756	367	1	[	[	X
admet-2756	367	2	41	41	NUM
admet-2756	367	3	]	]	X
admet-2756	367	4	w.l	w.l	PROPN
admet-2756	367	5	.	.	PROPN
admet-2756	367	6	ye	ye	PROPN
admet-2756	367	7	,	,	PUNCT
admet-2756	367	8	y.p	y.p	PROPN
admet-2756	367	9	.	.	PROPN
admet-2756	367	10	zhao	zhao	PROPN
admet-2756	367	11	,	,	PUNCT
admet-2756	367	12	h.q	h.q	PROPN
admet-2756	367	13	.	.	PROPN
admet-2756	367	14	li	li	PROPN
admet-2756	367	15	,	,	PUNCT
admet-2756	367	16	r.	r.	PROPN
admet-2756	367	17	na	na	PROPN
admet-2756	367	18	,	,	PUNCT
admet-2756	367	19	f.	f.	PROPN
admet-2756	367	20	li	li	PROPN
admet-2756	367	21	,	,	PUNCT
admet-2756	367	22	q.b	q.b	PROPN
admet-2756	367	23	.	.	PROPN
admet-2756	367	24	mei	mei	PROPN
admet-2756	367	25	,	,	PUNCT
admet-2756	367	26	m.g	m.g	PROPN
admet-2756	367	27	.	.	PROPN
admet-2756	367	28	zhao	zhao	PROPN
admet-2756	367	29	,	,	PUNCT
admet-2756	368	1	s.y	s.y	PROPN
admet-2756	368	2	.	.	PROPN
admet-2756	368	3	zhou	zhou	PROPN
admet-2756	368	4	.	.	PUNCT
admet-2756	369	1	doxorubicin	doxorubicin	PROPN
admet-2756	369	2	-	-	PUNCT
admet-2756	369	3	poly	poly	NOUN
admet-2756	369	4	(	(	PUNCT
admet-2756	369	5	ethylene	ethylene	NOUN
admet-2756	369	6	glycol)-alendronate	glycol)-alendronate	PROPN
admet-2756	369	7	self	self	NOUN
admet-2756	369	8	-	-	PUNCT
admet-2756	369	9	assembled	assemble	VERB
admet-2756	369	10	micelles	micelle	NOUN
admet-2756	369	11	for	for	ADP
admet-2756	369	12	targeted	target	VERB
admet-2756	369	13	therapy	therapy	NOUN
admet-2756	369	14	of	of	ADP
admet-2756	369	15	bone	bone	NOUN
admet-2756	369	16	metastatic	metastatic	ADJ
admet-2756	369	17	cancer	cancer	NOUN
admet-2756	369	18	.	.	PUNCT
admet-2756	370	1	scientific	scientific	ADJ
admet-2756	370	2	reports	report	NOUN
admet-2756	370	3	5	5	NUM
admet-2756	370	4	(	(	PUNCT
admet-2756	370	5	2015	2015	NUM
admet-2756	370	6	)	)	PUNCT
admet-2756	370	7	14614	14614	NUM
admet-2756	370	8	https://doi.org/10.1038/srep14614	https://doi.org/10.1038/srep14614	ADJ
admet-2756	371	1	[	[	X
admet-2756	371	2	42	42	NUM
admet-2756	371	3	]	]	PUNCT
admet-2756	371	4	j.	j.	PROPN
admet-2756	371	5	zhu	zhu	PROPN
admet-2756	371	6	,	,	PUNCT
admet-2756	371	7	q.	q.	PROPN
admet-2756	371	8	huo	huo	PROPN
admet-2756	371	9	,	,	PUNCT
admet-2756	371	10	m.	m.	NOUN
admet-2756	371	11	xu	xu	PROPN
admet-2756	371	12	,	,	PUNCT
admet-2756	371	13	f.	f.	PROPN
admet-2756	371	14	yang	yang	PROPN
admet-2756	371	15	,	,	PUNCT
admet-2756	371	16	y.	y.	PROPN
admet-2756	371	17	li	li	PROPN
admet-2756	371	18	,	,	PUNCT
admet-2756	371	19	h.	h.	PROPN
admet-2756	371	20	shi	shi	PROPN
admet-2756	371	21	,	,	PUNCT
admet-2756	371	22	y.	y.	PROPN
admet-2756	371	23	niu	niu	PROPN
admet-2756	371	24	,	,	PUNCT
admet-2756	371	25	y.	y.	PROPN
admet-2756	371	26	liu	liu	PROPN
admet-2756	371	27	.	.	PUNCT
admet-2756	371	28	bortezomib	bortezomib	NOUN
admet-2756	371	29	-	-	PUNCT
admet-2756	371	30	catechol	catechol	NOUN
admet-2756	371	31	conjugated	conjugate	VERB
admet-2756	371	32	prodrug	prodrug	NOUN
admet-2756	371	33	micelles	micelle	NOUN
admet-2756	371	34	:	:	PUNCT
admet-2756	371	35	combining	combine	VERB
admet-2756	371	36	bone	bone	NOUN
admet-2756	371	37	targeting	targeting	NOUN
admet-2756	371	38	and	and	CCONJ
admet-2756	371	39	aryl	aryl	NOUN
admet-2756	371	40	boronate	boronate	NOUN
admet-2756	371	41	-	-	PUNCT
admet-2756	371	42	based	base	VERB
admet-2756	371	43	ph	ph	ADJ
admet-2756	371	44	-	-	PUNCT
admet-2756	371	45	responsive	responsive	ADJ
admet-2756	371	46	drug	drug	NOUN
admet-2756	371	47	release	release	NOUN
admet-2756	371	48	for	for	ADP
admet-2756	371	49	cancer	cancer	NOUN
admet-2756	371	50	bone	bone	NOUN
admet-2756	371	51	-	-	PUNCT
admet-2756	371	52	metastasis	metastasis	NOUN
admet-2756	371	53	therapy	therapy	NOUN
admet-2756	371	54	.	.	PUNCT
admet-2756	372	1	nanoscale	nanoscale	NOUN
admet-2756	372	2	10	10	NUM
admet-2756	372	3	(	(	PUNCT
admet-2756	372	4	2018	2018	NUM
admet-2756	372	5	)	)	PUNCT
admet-2756	372	6	18387	18387	NUM
admet-2756	372	7	-	-	SYM
admet-2756	372	8	18397	18397	NUM
admet-2756	372	9	https://doi.org/10.1039/c8nr03899f	https://doi.org/10.1039/c8nr03899f	PROPN
admet-2756	373	1	[	[	X
admet-2756	373	2	43	43	NUM
admet-2756	373	3	]	]	X
admet-2756	373	4	y.	y.	NOUN
admet-2756	373	5	he	he	PRON
admet-2756	373	6	,	,	PUNCT
admet-2756	373	7	y.	y.	PROPN
admet-2756	373	8	huang	huang	PROPN
admet-2756	373	9	,	,	PUNCT
admet-2756	373	10	z.	z.	PROPN
admet-2756	373	11	huang	huang	PROPN
admet-2756	373	12	,	,	PUNCT
admet-2756	373	13	y.	y.	PROPN
admet-2756	373	14	jiang	jiang	PROPN
admet-2756	373	15	,	,	PUNCT
admet-2756	373	16	x.	x.	PROPN
admet-2756	373	17	sun	sun	PROPN
admet-2756	373	18	,	,	PUNCT
admet-2756	373	19	y.	y.	PROPN
admet-2756	373	20	shen	shen	PROPN
admet-2756	373	21	,	,	PUNCT
admet-2756	373	22	w.	w.	PROPN
admet-2756	373	23	chu	chu	PROPN
admet-2756	373	24	,	,	PUNCT
admet-2756	373	25	c.	c.	PROPN
admet-2756	373	26	zhao	zhao	PROPN
admet-2756	373	27	.	.	PUNCT
admet-2756	374	1	bisphosphonate	bisphosphonate	NOUN
admet-2756	374	2	-	-	PUNCT
admet-2756	374	3	functionalized	functionalize	VERB
admet-2756	374	4	coordination	coordination	NOUN
admet-2756	374	5	polymer	polymer	NOUN
admet-2756	374	6	nanoparticles	nanoparticle	NOUN
admet-2756	374	7	for	for	ADP
admet-2756	374	8	the	the	DET
admet-2756	374	9	treatment	treatment	NOUN
admet-2756	374	10	of	of	ADP
admet-2756	374	11	bone	bone	NOUN
admet-2756	374	12	metastatic	metastatic	ADJ
admet-2756	374	13	breast	breast	NOUN
admet-2756	374	14	cancer	cancer	NOUN
admet-2756	374	15	.	.	PUNCT
admet-2756	375	1	journal	journal	PROPN
admet-2756	375	2	of	of	ADP
admet-2756	375	3	controlled	control	VERB
admet-2756	375	4	release	release	NOUN
admet-2756	375	5	264	264	NUM
admet-2756	375	6	(	(	PUNCT
admet-2756	375	7	2017	2017	NUM
admet-2756	375	8	)	)	PUNCT
admet-2756	375	9	76	76	NUM
admet-2756	375	10	-	-	SYM
admet-2756	375	11	88	88	NUM
admet-2756	375	12	https://doi.org/10.1016/j.jconrel.2017.08.024	https://doi.org/10.1016/j.jconrel.2017.08.024	NOUN
admet-2756	375	13	[	[	X
admet-2756	375	14	44	44	NUM
admet-2756	375	15	]	]	PUNCT
admet-2756	375	16	s.	s.	PROPN
admet-2756	375	17	feng	feng	PROPN
admet-2756	375	18	,	,	PUNCT
admet-2756	375	19	z.x	z.x	PROPN
admet-2756	375	20	.	.	PROPN
admet-2756	375	21	wu	wu	PROPN
admet-2756	375	22	,	,	PUNCT
admet-2756	375	23	z.	z.	PROPN
admet-2756	375	24	zhao	zhao	PROPN
admet-2756	375	25	,	,	PUNCT
admet-2756	375	26	j.	j.	PROPN
admet-2756	375	27	liu	liu	PROPN
admet-2756	375	28	,	,	PUNCT
admet-2756	375	29	k.	k.	PROPN
admet-2756	375	30	sun	sun	PROPN
admet-2756	375	31	,	,	PUNCT
admet-2756	375	32	c.	c.	PROPN
admet-2756	375	33	guo	guo	PROPN
admet-2756	375	34	,	,	PUNCT
admet-2756	375	35	h.	h.	PROPN
admet-2756	375	36	wang	wang	PROPN
admet-2756	375	37	,	,	PUNCT
admet-2756	375	38	z.	z.	PROPN
admet-2756	375	39	wu	wu	PROPN
admet-2756	375	40	.	.	PUNCT
admet-2756	376	1	engineering	engineering	NOUN
admet-2756	376	2	of	of	ADP
admet-2756	376	3	bone	bone	NOUN
admet-2756	376	4	-	-	PUNCT
admet-2756	376	5	and	and	CCONJ
admet-2756	376	6	cd44	cd44	PROPN
admet-2756	376	7	-	-	PUNCT
admet-2756	376	8	dualtargeting	dualtargete	VERB
admet-2756	376	9	redox	redox	NOUN
admet-2756	376	10	-	-	PUNCT
admet-2756	376	11	sensitive	sensitive	ADJ
admet-2756	376	12	liposomes	liposome	NOUN
admet-2756	376	13	for	for	ADP
admet-2756	376	14	the	the	DET
admet-2756	376	15	treatment	treatment	NOUN
admet-2756	376	16	of	of	ADP
admet-2756	376	17	orthotopic	orthotopic	ADJ
admet-2756	376	18	osteosarcoma	osteosarcoma	NOUN
admet-2756	376	19	.	.	PUNCT
admet-2756	377	1	acs	acs	PROPN
admet-2756	377	2	applied	apply	VERB
admet-2756	377	3	materials	material	NOUN
admet-2756	377	4	&	&	CCONJ
admet-2756	377	5	interfaces	interface	NOUN
admet-2756	377	6	11	11	NUM
admet-2756	377	7	(	(	PUNCT
admet-2756	377	8	2019	2019	NUM
admet-2756	377	9	)	)	PUNCT
admet-2756	377	10	7357	7357	NUM
admet-2756	377	11	-	-	SYM
admet-2756	377	12	7368	7368	NUM
admet-2756	377	13	https://doi.org/10.1021/acsami.8b18820	https://doi.org/10.1021/acsami.8b18820	NOUN
admet-2756	378	1	[	[	X
admet-2756	378	2	45	45	NUM
admet-2756	378	3	]	]	X
admet-2756	378	4	y.	y.	NOUN
admet-2756	378	5	xi	xi	PROPN
admet-2756	378	6	,	,	PUNCT
admet-2756	378	7	t.	t.	PROPN
admet-2756	378	8	jiang	jiang	PROPN
admet-2756	378	9	,	,	PUNCT
admet-2756	378	10	y.	y.	PROPN
admet-2756	378	11	yu	yu	PROPN
admet-2756	378	12	,	,	PUNCT
admet-2756	378	13	j.	j.	PROPN
admet-2756	378	14	yu	yu	PROPN
admet-2756	378	15	,	,	PUNCT
admet-2756	378	16	m.	m.	PROPN
admet-2756	378	17	xue	xue	PROPN
admet-2756	378	18	,	,	PUNCT
admet-2756	378	19	n.	n.	PROPN
admet-2756	378	20	xu	xu	PROPN
admet-2756	378	21	,	,	PUNCT
admet-2756	378	22	j.	j.	PROPN
admet-2756	378	23	wen	wen	PROPN
admet-2756	378	24	,	,	PUNCT
admet-2756	378	25	w.	w.	PROPN
admet-2756	378	26	wang	wang	PROPN
admet-2756	378	27	,	,	PUNCT
admet-2756	378	28	h.	h.	PROPN
admet-2756	378	29	he	he	PROPN
admet-2756	378	30	,	,	PUNCT
admet-2756	378	31	y.	y.	PROPN
admet-2756	378	32	shen	shen	PROPN
admet-2756	378	33	,	,	PUNCT
admet-2756	378	34	d.	d.	PROPN
admet-2756	378	35	chen	chen	PROPN
admet-2756	378	36	.	.	PUNCT
admet-2756	379	1	dual	dual	ADJ
admet-2756	379	2	targeting	target	VERB
admet-2756	379	3	curcumin	curcumin	NOUN
admet-2756	379	4	loaded	load	VERB
admet-2756	379	5	alendronate	alendronate	ADJ
admet-2756	379	6	-	-	PUNCT
admet-2756	379	7	hyaluronan	hyaluronan	NOUN
admet-2756	379	8	-	-	PUNCT
admet-2756	379	9	octadecanoic	octadecanoic	ADJ
admet-2756	379	10	acid	acid	NOUN
admet-2756	379	11	micelles	micelle	NOUN
admet-2756	379	12	for	for	ADP
admet-2756	379	13	improving	improve	VERB
admet-2756	379	14	osteosarcoma	osteosarcoma	ADJ
admet-2756	379	15	therapy	therapy	NOUN
admet-2756	379	16	.	.	PUNCT
admet-2756	380	1	international	international	ADJ
admet-2756	380	2	journal	journal	PROPN
admet-2756	380	3	of	of	ADP
admet-2756	380	4	nanomedicine	nanomedicine	NOUN
admet-2756	380	5	14	14	NUM
admet-2756	380	6	(	(	PUNCT
admet-2756	380	7	2019	2019	NUM
admet-2756	380	8	)	)	PUNCT
admet-2756	380	9	6425	6425	NUM
admet-2756	380	10	-	-	SYM
admet-2756	380	11	6437	6437	NUM
admet-2756	380	12	http://doi.org/10.2147/ijn.s211981	http://doi.org/10.2147/ijn.s211981	NUM
admet-2756	381	1	[	[	X
admet-2756	381	2	46	46	NUM
admet-2756	381	3	]	]	PUNCT
admet-2756	381	4	h.	h.	PROPN
admet-2756	381	5	wu	wu	PROPN
admet-2756	381	6	,	,	PUNCT
admet-2756	381	7	y.	y.	PROPN
admet-2756	381	8	luo	luo	PROPN
admet-2756	381	9	,	,	PUNCT
admet-2756	381	10	d.	d.	PROPN
admet-2756	381	11	xu	xu	PROPN
admet-2756	381	12	,	,	PUNCT
admet-2756	381	13	x.	x.	PROPN
admet-2756	381	14	ke	ke	PROPN
admet-2756	381	15	,	,	PUNCT
admet-2756	381	16	t.	t.	PROPN
admet-2756	381	17	ci	ci	PROPN
admet-2756	381	18	.	.	PROPN
admet-2756	382	1	low	low	PROPN
admet-2756	382	2	molecular	molecular	ADJ
admet-2756	382	3	weight	weight	NOUN
admet-2756	382	4	heparin	heparin	ADJ
admet-2756	382	5	modified	modify	VERB
admet-2756	382	6	bone	bone	NOUN
admet-2756	382	7	targeting	target	VERB
admet-2756	382	8	liposomes	liposome	NOUN
admet-2756	382	9	for	for	ADP
admet-2756	382	10	orthotopic	orthotopic	ADJ
admet-2756	382	11	osteosarcoma	osteosarcoma	ADJ
admet-2756	382	12	and	and	CCONJ
admet-2756	382	13	breast	breast	NOUN
admet-2756	382	14	cancer	cancer	NOUN
admet-2756	382	15	bone	bone	NOUN
admet-2756	382	16	metastatic	metastatic	ADJ
admet-2756	382	17	tumors	tumor	NOUN
admet-2756	382	18	.	.	PUNCT
admet-2756	383	1	international	international	ADJ
admet-2756	383	2	journal	journal	NOUN
admet-2756	383	3	of	of	ADP
admet-2756	383	4	biological	biological	ADJ
admet-2756	383	5	macromolecules	macromolecule	NOUN
admet-2756	383	6	164	164	NUM
admet-2756	383	7	(	(	PUNCT
admet-2756	383	8	2020	2020	NUM
admet-2756	383	9	)	)	PUNCT
admet-2756	383	10	2583	2583	NUM
admet-2756	383	11	-	-	SYM
admet-2756	383	12	2597	2597	NUM
admet-2756	383	13	https://doi.org/10.1016/j.ijbiomac.2020.08.068	https://doi.org/10.1016/j.ijbiomac.2020.08.068	PROPN
admet-2756	383	14	[	[	X
admet-2756	383	15	47	47	NUM
admet-2756	383	16	]	]	X
admet-2756	383	17	y.	y.	PROPN
admet-2756	383	18	huang	huang	PROPN
admet-2756	383	19	,	,	PUNCT
admet-2756	383	20	z.	z.	PROPN
admet-2756	383	21	xiao	xiao	PROPN
admet-2756	383	22	,	,	PUNCT
admet-2756	383	23	z.	z.	PROPN
admet-2756	383	24	guan	guan	PROPN
admet-2756	383	25	,	,	PUNCT
admet-2756	383	26	y.	y.	PROPN
admet-2756	383	27	shen	shen	PROPN
admet-2756	383	28	,	,	PUNCT
admet-2756	383	29	y.	y.	PROPN
admet-2756	383	30	jiang	jiang	PROPN
admet-2756	383	31	,	,	PUNCT
admet-2756	383	32	x.	x.	PROPN
admet-2756	383	33	xu	xu	PROPN
admet-2756	383	34	,	,	PUNCT
admet-2756	383	35	z.	z.	PROPN
admet-2756	383	36	huang	huang	PROPN
admet-2756	383	37	,	,	PUNCT
admet-2756	383	38	c.	c.	PROPN
admet-2756	383	39	zhao	zhao	PROPN
admet-2756	383	40	.	.	PUNCT
admet-2756	384	1	a	a	DET
admet-2756	384	2	light	light	ADV
admet-2756	384	3	-	-	PUNCT
admet-2756	384	4	triggered	trigger	VERB
admet-2756	384	5	self	self	NOUN
admet-2756	384	6	-	-	PUNCT
admet-2756	384	7	reinforced	reinforce	VERB
admet-2756	384	8	nanoagent	nanoagent	NOUN
admet-2756	384	9	for	for	ADP
admet-2756	384	10	targeted	target	VERB
admet-2756	384	11	chemo	chemo	NOUN
admet-2756	384	12	-	-	PUNCT
admet-2756	384	13	photodynamic	photodynamic	ADJ
admet-2756	384	14	therapy	therapy	NOUN
admet-2756	384	15	of	of	ADP
admet-2756	384	16	breast	breast	NOUN
admet-2756	384	17	cancer	cancer	NOUN
admet-2756	384	18	bone	bone	NOUN
admet-2756	384	19	metastases	metastasis	NOUN
admet-2756	384	20	via	via	ADP
admet-2756	384	21	er	er	INTJ
admet-2756	384	22	stress	stress	NOUN
admet-2756	384	23	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	384	24	https://doi.org/10.1021/acsami.7b08108	https://doi.org/10.1021/acsami.7b08108	PROPN
admet-2756	384	25	https://doi.org/10.1016/j.jiec.2019.03.055	https://doi.org/10.1016/j.jiec.2019.03.055	ADV
admet-2756	384	26	https://doi.org/10.1172/jci115539	https://doi.org/10.1172/jci115539	PUNCT
admet-2756	384	27	https://doi.org/10.1016/j.jconrel.2011.11.020	https://doi.org/10.1016/j.jconrel.2011.11.020	NOUN
admet-2756	384	28	https://doi.org/10.3390/biomedicines8110492	https://doi.org/10.3390/biomedicines8110492	NOUN
admet-2756	384	29	http://dx.doi.org/10.1016/b978-0-12-415797-2.00006-6	http://dx.doi.org/10.1016/b978-0-12-415797-2.00006-6	NOUN
admet-2756	384	30	http://dx.doi.org/10.1016/b978-0-12-415797-2.00006-6	http://dx.doi.org/10.1016/b978-0-12-415797-2.00006-6	PROPN
admet-2756	384	31	https://doi.org/10.1016/j.jconrel.2021.02.031	https://doi.org/10.1016/j.jconrel.2021.02.031	NOUN
admet-2756	384	32	https://doi.org/10.1186/1556-276x-8-102	https://doi.org/10.1186/1556-276x-8-102	NUM
admet-2756	384	33	https://doi.org/10.1038/nrc.2016.108	https://doi.org/10.1038/nrc.2016.108	ADP
admet-2756	384	34	https://doi.org/10.1038/srep14614	https://doi.org/10.1038/srep14614	ADJ
admet-2756	384	35	https://doi.org/10.1039/c8nr03899f	https://doi.org/10.1039/c8nr03899f	PROPN
admet-2756	384	36	https://doi.org/10.1016/j.jconrel.2017.08.024	https://doi.org/10.1016/j.jconrel.2017.08.024	PROPN
admet-2756	384	37	https://doi.org/10.1021/acsami.8b18820	https://doi.org/10.1021/acsami.8b18820	NOUN
admet-2756	384	38	http://doi.org/10.2147/ijn.s211981	http://doi.org/10.2147/ijn.s211981	NUM
admet-2756	384	39	https://doi.org/10.1016/j.ijbiomac.2020.08.068	https://doi.org/10.1016/j.ijbiomac.2020.08.068	PROPN
admet-2756	384	40	m.	m.	PROPN
admet-2756	384	41	eshaghi	eshaghi	PROPN
admet-2756	384	42	et	et	PROPN
admet-2756	384	43	al	al	PROPN
admet-2756	384	44	.	.	PROPN
admet-2756	384	45	admet	admet	PROPN
admet-2756	384	46	&	&	CCONJ
admet-2756	384	47	dmpk	dmpk	PROPN
admet-2756	384	48	13(3	13(3	NUM
admet-2756	384	49	)	)	PUNCT
admet-2756	384	50	(	(	PUNCT
admet-2756	384	51	2025	2025	NUM
admet-2756	384	52	)	)	PUNCT
admet-2756	384	53	2756	2756	NUM
admet-2756	384	54	16	16	NUM
admet-2756	384	55	and	and	CCONJ
admet-2756	384	56	mitochondria	mitochondria	NOUN
admet-2756	384	57	mediated	mediate	VERB
admet-2756	384	58	apoptotic	apoptotic	ADJ
admet-2756	384	59	pathways	pathway	NOUN
admet-2756	384	60	.	.	PUNCT
admet-2756	385	1	journal	journal	PROPN
admet-2756	385	2	of	of	ADP
admet-2756	385	3	controlled	control	VERB
admet-2756	385	4	release	release	NOUN
admet-2756	385	5	319	319	NUM
admet-2756	385	6	(	(	PUNCT
admet-2756	385	7	2020	2020	NUM
admet-2756	385	8	)	)	PUNCT
admet-2756	385	9	119	119	NUM
admet-2756	385	10	-	-	SYM
admet-2756	385	11	134	134	NUM
admet-2756	385	12	https://doi.org/10.1016/j.jconrel.2019.12.043	https://doi.org/10.1016/j.jconrel.2019.12.043	NOUN
admet-2756	385	13	[	[	X
admet-2756	385	14	48	48	NUM
admet-2756	385	15	]	]	X
admet-2756	385	16	y.	y.	PROPN
admet-2756	385	17	huang	huang	PROPN
admet-2756	385	18	,	,	PUNCT
admet-2756	385	19	z.	z.	PROPN
admet-2756	385	20	xiao	xiao	PROPN
admet-2756	385	21	,	,	PUNCT
admet-2756	385	22	z.	z.	PROPN
admet-2756	385	23	guan	guan	PROPN
admet-2756	385	24	,	,	PUNCT
admet-2756	385	25	z.	z.	PROPN
admet-2756	385	26	zeng	zeng	PROPN
admet-2756	385	27	,	,	PUNCT
admet-2756	385	28	y.	y.	PROPN
admet-2756	385	29	shen	shen	PROPN
admet-2756	385	30	,	,	PUNCT
admet-2756	385	31	x.	x.	PROPN
admet-2756	385	32	xu	xu	PROPN
admet-2756	385	33	,	,	PUNCT
admet-2756	385	34	c.	c.	PROPN
admet-2756	385	35	zhao	zhao	PROPN
admet-2756	385	36	.	.	PUNCT
admet-2756	386	1	bone	bone	NOUN
admet-2756	386	2	-	-	PUNCT
admet-2756	386	3	seeking	seek	VERB
admet-2756	386	4	nanoplatform	nanoplatform	NOUN
admet-2756	386	5	co	co	VERB
admet-2756	387	1	-	-	VERB
admet-2756	387	2	delivering	deliver	VERB
admet-2756	387	3	cisplatin	cisplatin	NOUN
admet-2756	387	4	and	and	CCONJ
admet-2756	387	5	zoledronate	zoledronate	NOUN
admet-2756	387	6	for	for	ADP
admet-2756	387	7	synergistic	synergistic	ADJ
admet-2756	387	8	therapy	therapy	NOUN
admet-2756	387	9	of	of	ADP
admet-2756	387	10	breast	breast	NOUN
admet-2756	387	11	cancer	cancer	NOUN
admet-2756	387	12	bone	bone	NOUN
admet-2756	387	13	metastasis	metastasis	NOUN
admet-2756	387	14	and	and	CCONJ
admet-2756	387	15	bone	bone	NOUN
admet-2756	387	16	resorption	resorption	NOUN
admet-2756	387	17	.	.	PUNCT
admet-2756	388	1	acta	acta	PROPN
admet-2756	388	2	pharmaceutica	pharmaceutica	PROPN
admet-2756	388	3	sinica	sinica	PROPN
admet-2756	388	4	b	b	PROPN
admet-2756	388	5	10	10	NUM
admet-2756	388	6	(	(	PUNCT
admet-2756	388	7	2020	2020	NUM
admet-2756	388	8	)	)	PUNCT
admet-2756	388	9	2384	2384	NUM
admet-2756	388	10	-	-	SYM
admet-2756	388	11	2403	2403	NUM
admet-2756	388	12	https://doi.org/10.1016/j.apsb.2020.06.006	https://doi.org/10.1016/j.apsb.2020.06.006	PROPN
admet-2756	388	13	[	[	X
admet-2756	388	14	49	49	NUM
admet-2756	388	15	]	]	X
admet-2756	388	16	g.	g.	PROPN
admet-2756	388	17	bonzi	bonzi	PROPN
admet-2756	388	18	,	,	PUNCT
admet-2756	388	19	s.	s.	PROPN
admet-2756	388	20	salmaso	salmaso	PROPN
admet-2756	388	21	,	,	PUNCT
admet-2756	388	22	a.	a.	PROPN
admet-2756	388	23	scomparin	scomparin	PROPN
admet-2756	388	24	,	,	PUNCT
admet-2756	388	25	a.	a.	PROPN
admet-2756	388	26	eldar	eldar	NOUN
admet-2756	388	27	-	-	PUNCT
admet-2756	388	28	boock	boock	NOUN
admet-2756	388	29	,	,	PUNCT
admet-2756	388	30	r.	r.	PROPN
admet-2756	388	31	satchi	satchi	PROPN
admet-2756	388	32	-	-	PUNCT
admet-2756	388	33	fainaro	fainaro	NOUN
admet-2756	388	34	,	,	PUNCT
admet-2756	388	35	p.	p.	NOUN
admet-2756	388	36	caliceti	caliceti	PROPN
admet-2756	388	37	.	.	PUNCT
admet-2756	389	1	novel	novel	ADJ
admet-2756	389	2	pullulan	pullulan	NOUN
admet-2756	389	3	bioconjugate	bioconjugate	NOUN
admet-2756	389	4	for	for	ADP
admet-2756	389	5	selective	selective	ADJ
admet-2756	389	6	breast	breast	NOUN
admet-2756	389	7	cancer	cancer	NOUN
admet-2756	389	8	bone	bone	NOUN
admet-2756	389	9	metastases	metastasis	NOUN
admet-2756	389	10	treatment	treatment	NOUN
admet-2756	389	11	.	.	PUNCT
admet-2756	390	1	bioconjugate	bioconjugate	NOUN
admet-2756	390	2	chemistry	chemistry	NOUN
admet-2756	390	3	26	26	NUM
admet-2756	390	4	(	(	PUNCT
admet-2756	390	5	2015	2015	NUM
admet-2756	390	6	)	)	PUNCT
admet-2756	390	7	489	489	NUM
admet-2756	390	8	-	-	SYM
admet-2756	390	9	501	501	NUM
admet-2756	390	10	https://doi.org/10.1021/bc500614b	https://doi.org/10.1021/bc500614b	NOUN
admet-2756	391	1	[	[	X
admet-2756	391	2	50	50	NUM
admet-2756	391	3	]	]	X
admet-2756	391	4	m.s	m.s	PROPN
admet-2756	391	5	.	.	PROPN
admet-2756	391	6	alaei	alaei	PROPN
admet-2756	391	7	,	,	PUNCT
admet-2756	391	8	f.	f.	PROPN
admet-2756	391	9	ganji	ganji	PROPN
admet-2756	391	10	,	,	PUNCT
admet-2756	391	11	h.	h.	PROPN
admet-2756	391	12	shaki	shaki	PROPN
admet-2756	391	13	.	.	PUNCT
admet-2756	392	1	in	in	ADP
admet-2756	392	2	vitro	vitro	X
admet-2756	392	3	preparation	preparation	NOUN
admet-2756	392	4	and	and	CCONJ
admet-2756	392	5	evaluation	evaluation	NOUN
admet-2756	392	6	of	of	ADP
admet-2756	392	7	alendronate	alendronate	NOUN
admet-2756	392	8	-	-	PUNCT
admet-2756	392	9	modified	modify	VERB
admet-2756	392	10	hyaluronic	hyaluronic	ADJ
admet-2756	392	11	acid	acid	NOUN
admet-2756	392	12	-	-	PUNCT
admet-2756	392	13	based	base	VERB
admet-2756	392	14	nanomicelles	nanomicelle	NOUN
admet-2756	392	15	as	as	ADP
admet-2756	392	16	a	a	DET
admet-2756	392	17	bone	bone	NOUN
admet-2756	392	18	-	-	PUNCT
admet-2756	392	19	targeted	target	VERB
admet-2756	392	20	drug	drug	NOUN
admet-2756	392	21	delivery	delivery	NOUN
admet-2756	392	22	system	system	NOUN
admet-2756	392	23	.	.	PUNCT
admet-2756	393	1	journal	journal	PROPN
admet-2756	393	2	of	of	ADP
admet-2756	393	3	drug	drug	NOUN
admet-2756	393	4	delivery	delivery	NOUN
admet-2756	393	5	science	science	NOUN
admet-2756	393	6	and	and	CCONJ
admet-2756	393	7	technology	technology	NOUN
admet-2756	393	8	101	101	NUM
admet-2756	393	9	(	(	PUNCT
admet-2756	393	10	2024	2024	NUM
admet-2756	393	11	)	)	PUNCT
admet-2756	393	12	106256	106256	NUM
admet-2756	393	13	.	.	PUNCT
admet-2756	394	1	https://doi.org/10.1016/j.jddst.2024.106256	https://doi.org/10.1016/j.jddst.2024.106256	PROPN
admet-2756	395	1	[	[	X
admet-2756	395	2	51	51	NUM
admet-2756	395	3	]	]	X
admet-2756	395	4	t.d.t	t.d.t	ADJ
admet-2756	395	5	.	.	PUNCT
admet-2756	395	6	nguyen	nguyen	PROPN
admet-2756	395	7	,	,	PUNCT
admet-2756	395	8	a.	a.	NOUN
admet-2756	395	9	pitchaimani	pitchaimani	PROPN
admet-2756	395	10	,	,	PUNCT
admet-2756	395	11	s.	s.	PROPN
admet-2756	395	12	aryal	aryal	PROPN
admet-2756	395	13	.	.	PUNCT
admet-2756	396	1	engineered	engineer	VERB
admet-2756	396	2	nanomedicine	nanomedicine	NOUN
admet-2756	396	3	with	with	ADP
admet-2756	396	4	alendronic	alendronic	ADJ
admet-2756	396	5	acid	acid	NOUN
admet-2756	396	6	corona	corona	NOUN
admet-2756	396	7	improves	improve	VERB
admet-2756	396	8	targeting	target	VERB
admet-2756	396	9	to	to	ADP
admet-2756	396	10	osteosarcoma	osteosarcoma	VERB
admet-2756	396	11	.	.	PUNCT
admet-2756	397	1	scientific	scientific	ADJ
admet-2756	397	2	reports	report	NOUN
admet-2756	397	3	6	6	NUM
admet-2756	397	4	(	(	PUNCT
admet-2756	397	5	2016	2016	NUM
admet-2756	397	6	)	)	PUNCT
admet-2756	397	7	36707	36707	NUM
admet-2756	397	8	https://doi.org/10.1038/srep36707	https://doi.org/10.1038/srep36707	NOUN
admet-2756	397	9	[	[	X
admet-2756	397	10	52	52	NUM
admet-2756	397	11	]	]	PUNCT
admet-2756	397	12	s.	s.	PROPN
admet-2756	397	13	kozlu	kozlu	PROPN
admet-2756	397	14	,	,	PUNCT
admet-2756	397	15	s.	s.	PROPN
admet-2756	397	16	sahin	sahin	PROPN
admet-2756	397	17	,	,	PUNCT
admet-2756	397	18	g.	g.	PROPN
admet-2756	397	19	ultav	ultav	PROPN
admet-2756	397	20	,	,	PUNCT
admet-2756	397	21	f.	f.	PROPN
admet-2756	397	22	yerlikaya	yerlikaya	PROPN
admet-2756	397	23	,	,	PUNCT
admet-2756	397	24	s.	s.	PROPN
admet-2756	397	25	calis	calis	PROPN
admet-2756	397	26	,	,	PUNCT
admet-2756	397	27	y.	y.	PROPN
admet-2756	397	28	capan	capan	PROPN
admet-2756	397	29	.	.	PUNCT
admet-2756	398	1	development	development	NOUN
admet-2756	398	2	and	and	CCONJ
admet-2756	398	3	in	in	ADP
admet-2756	398	4	vitro	vitro	X
admet-2756	398	5	evaluation	evaluation	NOUN
admet-2756	398	6	of	of	ADP
admet-2756	398	7	doxorubicin	doxorubicin	PROPN
admet-2756	398	8	and	and	CCONJ
admet-2756	398	9	celecoxib	celecoxib	VERB
admet-2756	398	10	co	co	VERB
admet-2756	398	11	-	-	ADJ
admet-2756	398	12	loaded	load	VERB
admet-2756	398	13	bone	bone	NOUN
admet-2756	398	14	targeted	target	VERB
admet-2756	398	15	nanoparticles	nanoparticle	NOUN
admet-2756	398	16	.	.	PUNCT
admet-2756	399	1	journal	journal	NOUN
admet-2756	399	2	of	of	ADP
admet-2756	399	3	drug	drug	NOUN
admet-2756	399	4	delivery	delivery	NOUN
admet-2756	399	5	science	science	NOUN
admet-2756	399	6	and	and	CCONJ
admet-2756	399	7	technology	technology	NOUN
admet-2756	399	8	45	45	NUM
admet-2756	399	9	(	(	PUNCT
admet-2756	399	10	2018	2018	NUM
admet-2756	399	11	)	)	PUNCT
admet-2756	399	12	213	213	NUM
admet-2756	399	13	-	-	SYM
admet-2756	399	14	219	219	NUM
admet-2756	399	15	https://doi.org/10.1016/j.jddst.2018.02.004	https://doi.org/10.1016/j.jddst.2018.02.004	NOUN
admet-2756	399	16	[	[	X
admet-2756	399	17	53	53	NUM
admet-2756	399	18	]	]	X
admet-2756	399	19	y.	y.	PROPN
admet-2756	399	20	yuan	yuan	PROPN
admet-2756	399	21	,	,	PUNCT
admet-2756	399	22	j.x	j.x	PROPN
admet-2756	399	23	.	.	PROPN
admet-2756	399	24	song	song	PROPN
admet-2756	399	25	,	,	PUNCT
admet-2756	399	26	m.n	m.n	PROPN
admet-2756	399	27	.	.	PROPN
admet-2756	399	28	zhang	zhang	PROPN
admet-2756	399	29	,	,	PUNCT
admet-2756	399	30	b.s	b.s	PROPN
admet-2756	399	31	.	.	PROPN
admet-2756	399	32	yuan	yuan	PROPN
admet-2756	399	33	.	.	PUNCT
admet-2756	400	1	a	a	DET
admet-2756	400	2	multiple	multiple	ADJ
admet-2756	400	3	drug	drug	NOUN
admet-2756	400	4	loaded	load	VERB
admet-2756	400	5	,	,	PUNCT
admet-2756	400	6	functionalized	functionalize	VERB
admet-2756	400	7	ph	ph	ADJ
admet-2756	400	8	-	-	ADJ
admet-2756	400	9	sensitive	sensitive	ADJ
admet-2756	400	10	nanocarrier	nanocarrier	NOUN
admet-2756	400	11	as	as	ADP
admet-2756	400	12	therapeutic	therapeutic	ADJ
admet-2756	400	13	and	and	CCONJ
admet-2756	400	14	epigenetic	epigenetic	ADJ
admet-2756	400	15	modulator	modulator	NOUN
admet-2756	400	16	for	for	ADP
admet-2756	400	17	osteosarcoma	osteosarcoma	NOUN
admet-2756	400	18	.	.	PUNCT
admet-2756	401	1	scientific	scientific	ADJ
admet-2756	401	2	reports	report	NOUN
admet-2756	401	3	10	10	NUM
admet-2756	401	4	(	(	PUNCT
admet-2756	401	5	2020	2020	NUM
admet-2756	401	6	)	)	PUNCT
admet-2756	401	7	15497	15497	NUM
admet-2756	401	8	https://doi.org/10.1038/s41598-020-72552-z	https://doi.org/10.1038/s41598-020-72552-z	VERB
admet-2756	401	9	[	[	X
admet-2756	401	10	54	54	NUM
admet-2756	401	11	]	]	SYM
admet-2756	401	12	s.b	s.b	PROPN
admet-2756	401	13	.	.	PROPN
admet-2756	401	14	bai	bai	PROPN
admet-2756	401	15	,	,	PUNCT
admet-2756	401	16	d.z	d.z	PROPN
admet-2756	401	17	.	.	PROPN
admet-2756	401	18	liu	liu	PROPN
admet-2756	401	19	,	,	PUNCT
admet-2756	401	20	y.	y.	PROPN
admet-2756	401	21	cheng	cheng	PROPN
admet-2756	401	22	,	,	PUNCT
admet-2756	401	23	h.	h.	PROPN
admet-2756	401	24	cui	cui	PROPN
admet-2756	401	25	,	,	PUNCT
admet-2756	401	26	m.	m.	PROPN
admet-2756	401	27	liu	liu	PROPN
admet-2756	401	28	,	,	PUNCT
admet-2756	401	29	m.x	m.x	PROPN
admet-2756	401	30	.	.	PROPN
admet-2756	401	31	cui	cui	PROPN
admet-2756	401	32	,	,	PUNCT
admet-2756	401	33	q.b	q.b	PROPN
admet-2756	401	34	.	.	PROPN
admet-2756	401	35	mei	mei	PROPN
admet-2756	401	36	,	,	PUNCT
admet-2756	402	1	s.y	s.y	PROPN
admet-2756	402	2	.	.	PROPN
admet-2756	402	3	zhou	zhou	PROPN
admet-2756	402	4	.	.	PUNCT
admet-2756	403	1	osteoclasts	osteoclast	NOUN
admet-2756	403	2	and	and	CCONJ
admet-2756	403	3	tumor	tumor	NOUN
admet-2756	403	4	cells	cell	NOUN
admet-2756	403	5	dual	dual	ADJ
admet-2756	403	6	targeting	target	VERB
admet-2756	403	7	nanoparticle	nanoparticle	NOUN
admet-2756	403	8	to	to	PART
admet-2756	403	9	treat	treat	VERB
admet-2756	403	10	bone	bone	NOUN
admet-2756	403	11	metastases	metastasis	NOUN
admet-2756	403	12	of	of	ADP
admet-2756	403	13	lung	lung	NOUN
admet-2756	403	14	cancer	cancer	NOUN
admet-2756	403	15	.	.	PUNCT
admet-2756	404	1	nanomedicine	nanomedicine	PROPN
admet-2756	404	2	:	:	PUNCT
admet-2756	404	3	nanotechnology	nanotechnology	NOUN
admet-2756	404	4	,	,	PUNCT
admet-2756	404	5	biology	biology	NOUN
admet-2756	404	6	and	and	CCONJ
admet-2756	404	7	medicine	medicine	NOUN
admet-2756	404	8	21	21	NUM
admet-2756	404	9	(	(	PUNCT
admet-2756	404	10	2019	2019	NUM
admet-2756	404	11	)	)	PUNCT
admet-2756	404	12	102054	102054	NUM
admet-2756	405	1	https://doi.org/10.1016/j.nano.2019.102054	https://doi.org/10.1016/j.nano.2019.102054	PROPN
admet-2756	405	2	[	[	X
admet-2756	405	3	55	55	NUM
admet-2756	405	4	]	]	X
admet-2756	405	5	n.w	n.w	PROPN
admet-2756	405	6	.	.	PROPN
admet-2756	405	7	kang	kang	PROPN
admet-2756	405	8	,	,	PUNCT
admet-2756	405	9	j.y	j.y	PROPN
admet-2756	405	10	.	.	PROPN
admet-2756	405	11	lee	lee	PROPN
admet-2756	405	12	,	,	PUNCT
admet-2756	406	1	d.d	d.d	PROPN
admet-2756	406	2	.	.	PROPN
admet-2756	406	3	kim	kim	PROPN
admet-2756	406	4	.	.	PUNCT
admet-2756	406	5	hydroxyapatite	hydroxyapatite	NOUN
admet-2756	406	6	-	-	PUNCT
admet-2756	406	7	binding	bind	VERB
admet-2756	406	8	albumin	albumin	ADJ
admet-2756	406	9	nanoclusters	nanocluster	NOUN
admet-2756	406	10	for	for	ADP
admet-2756	406	11	enhancing	enhance	VERB
admet-2756	406	12	bone	bone	NOUN
admet-2756	406	13	tumor	tumor	NOUN
admet-2756	406	14	chemotherapy	chemotherapy	NOUN
admet-2756	406	15	.	.	PUNCT
admet-2756	407	1	journal	journal	PROPN
admet-2756	407	2	of	of	ADP
admet-2756	407	3	controlled	control	VERB
admet-2756	407	4	release	release	NOUN
admet-2756	407	5	342	342	NUM
admet-2756	407	6	(	(	PUNCT
admet-2756	407	7	2022	2022	NUM
admet-2756	407	8	)	)	PUNCT
admet-2756	407	9	111	111	NUM
admet-2756	407	10	-	-	SYM
admet-2756	407	11	121	121	NUM
admet-2756	407	12	https://doi.org/10.1016/j.jconrel.2021.12.039	https://doi.org/10.1016/j.jconrel.2021.12.039	NOUN
admet-2756	407	13	[	[	X
admet-2756	407	14	56	56	NUM
admet-2756	407	15	]	]	PUNCT
admet-2756	407	16	k.	k.	PROPN
admet-2756	407	17	miller	miller	PROPN
admet-2756	407	18	,	,	PUNCT
admet-2756	407	19	c.	c.	PROPN
admet-2756	407	20	clementi	clementi	PROPN
admet-2756	407	21	,	,	PUNCT
admet-2756	407	22	d.	d.	PROPN
admet-2756	407	23	polyak	polyak	PROPN
admet-2756	407	24	,	,	PUNCT
admet-2756	407	25	a.	a.	PROPN
admet-2756	407	26	eldar	eldar	NOUN
admet-2756	407	27	-	-	PUNCT
admet-2756	407	28	boock	boock	NOUN
admet-2756	407	29	,	,	PUNCT
admet-2756	407	30	l.	l.	PROPN
admet-2756	407	31	benayoun	benayoun	PROPN
admet-2756	407	32	,	,	PUNCT
admet-2756	407	33	i.	i.	PROPN
admet-2756	407	34	barshack	barshack	PROPN
admet-2756	407	35	,	,	PUNCT
admet-2756	407	36	y.	y.	PROPN
admet-2756	407	37	shaked	shaked	PROPN
admet-2756	407	38	,	,	PUNCT
admet-2756	407	39	g.	g.	PROPN
admet-2756	407	40	pasut	pasut	PROPN
admet-2756	407	41	,	,	PUNCT
admet-2756	407	42	r.	r.	PROPN
admet-2756	407	43	satchi	satchi	PROPN
admet-2756	407	44	-	-	PUNCT
admet-2756	407	45	fainaro	fainaro	NOUN
admet-2756	407	46	.	.	PUNCT
admet-2756	408	1	poly(ethylene	poly(ethylene	PROPN
admet-2756	408	2	glycol)-paclitaxel	glycol)-paclitaxel	PROPN
admet-2756	408	3	-	-	PUNCT
admet-2756	408	4	alendronate	alendronate	NOUN
admet-2756	408	5	self	self	NOUN
admet-2756	408	6	-	-	PUNCT
admet-2756	408	7	assembled	assemble	VERB
admet-2756	408	8	micelles	micelle	NOUN
admet-2756	408	9	for	for	ADP
admet-2756	408	10	the	the	DET
admet-2756	408	11	targeted	target	VERB
admet-2756	408	12	treatment	treatment	NOUN
admet-2756	408	13	of	of	ADP
admet-2756	408	14	breast	breast	NOUN
admet-2756	408	15	cancer	cancer	NOUN
admet-2756	408	16	bone	bone	NOUN
admet-2756	408	17	metastases	metastasis	NOUN
admet-2756	408	18	.	.	PUNCT
admet-2756	409	1	biomaterials	biomaterial	NOUN
admet-2756	409	2	34	34	NUM
admet-2756	409	3	(	(	PUNCT
admet-2756	409	4	2013	2013	NUM
admet-2756	409	5	)	)	PUNCT
admet-2756	409	6	3795	3795	NUM
admet-2756	409	7	-	-	SYM
admet-2756	409	8	806	806	NUM
admet-2756	409	9	https://doi.org/10.1016/j.biomaterials.2013.01.052	https://doi.org/10.1016/j.biomaterials.2013.01.052	NOUN
admet-2756	409	10	[	[	X
admet-2756	409	11	57	57	NUM
admet-2756	409	12	]	]	X
admet-2756	409	13	d.	d.	PROPN
admet-2756	409	14	dos	dos	PROPN
admet-2756	409	15	santos	santos	PROPN
admet-2756	409	16	ferreira	ferreira	PROPN
admet-2756	409	17	,	,	PUNCT
admet-2756	409	18	b.l.j	b.l.j	NOUN
admet-2756	409	19	.	.	PUNCT
admet-2756	410	1	de	de	PROPN
admet-2756	410	2	oliveira	oliveira	PROPN
admet-2756	410	3	pinto	pinto	PROPN
admet-2756	410	4	,	,	PUNCT
admet-2756	410	5	v.	v.	PROPN
admet-2756	410	6	kumar	kumar	PROPN
admet-2756	410	7	,	,	PUNCT
admet-2756	410	8	v.n	v.n	PROPN
admet-2756	410	9	.	.	PROPN
admet-2756	410	10	cardoso	cardoso	PROPN
admet-2756	410	11	,	,	PUNCT
admet-2756	410	12	s.o	s.o	PROPN
admet-2756	410	13	.	.	PROPN
admet-2756	410	14	fernandes	fernandes	PROPN
admet-2756	410	15	,	,	PUNCT
admet-2756	410	16	c.m	c.m	PROPN
admet-2756	410	17	.	.	PROPN
admet-2756	410	18	souza	souza	PROPN
admet-2756	410	19	,	,	PUNCT
admet-2756	410	20	g.d	g.d	PROPN
admet-2756	410	21	.	.	PROPN
admet-2756	410	22	cassali	cassali	PROPN
admet-2756	410	23	,	,	PUNCT
admet-2756	410	24	a.	a.	PROPN
admet-2756	410	25	moore	moore	PROPN
admet-2756	410	26	,	,	PUNCT
admet-2756	410	27	d.e	d.e	PROPN
admet-2756	410	28	.	.	PROPN
admet-2756	410	29	sosnovik	sosnovik	PROPN
admet-2756	410	30	,	,	PUNCT
admet-2756	410	31	c.t	c.t	PROPN
admet-2756	410	32	.	.	PROPN
admet-2756	410	33	farrar	farrar	PROPN
admet-2756	410	34	e.a	e.a	PROPN
admet-2756	410	35	.	.	PROPN
admet-2756	410	36	leite	leite	PROPN
admet-2756	410	37	.	.	PUNCT
admet-2756	411	1	evaluation	evaluation	NOUN
admet-2756	411	2	of	of	ADP
admet-2756	411	3	antitumor	antitumor	PROPN
admet-2756	411	4	activity	activity	NOUN
admet-2756	411	5	and	and	CCONJ
admet-2756	411	6	cardiac	cardiac	ADJ
admet-2756	411	7	toxicity	toxicity	NOUN
admet-2756	411	8	of	of	ADP
admet-2756	411	9	a	a	DET
admet-2756	411	10	bone	bone	NOUN
admet-2756	411	11	-	-	PUNCT
admet-2756	411	12	targeted	target	VERB
admet-2756	411	13	ph	ph	ADJ
admet-2756	411	14	-	-	ADJ
admet-2756	411	15	sensitive	sensitive	ADJ
admet-2756	411	16	liposomal	liposomal	ADJ
admet-2756	411	17	formulation	formulation	NOUN
admet-2756	411	18	in	in	ADP
admet-2756	411	19	a	a	DET
admet-2756	411	20	bone	bone	NOUN
admet-2756	411	21	metastasis	metastasis	NOUN
admet-2756	411	22	tumor	tumor	NOUN
admet-2756	411	23	model	model	NOUN
admet-2756	411	24	in	in	ADP
admet-2756	411	25	mice	mouse	NOUN
admet-2756	411	26	.	.	PUNCT
admet-2756	412	1	nanomedicine	nanomedicine	NOUN
admet-2756	412	2	:	:	PUNCT
admet-2756	412	3	nanotechnology	nanotechnology	NOUN
admet-2756	412	4	,	,	PUNCT
admet-2756	412	5	biology	biology	NOUN
admet-2756	412	6	and	and	CCONJ
admet-2756	412	7	medicine	medicine	NOUN
admet-2756	412	8	13	13	NUM
admet-2756	412	9	(	(	PUNCT
admet-2756	412	10	2017	2017	NUM
admet-2756	412	11	)	)	PUNCT
admet-2756	412	12	1693	1693	NUM
admet-2756	412	13	-	-	SYM
admet-2756	412	14	1701	1701	NUM
admet-2756	412	15	https://doi.org/10.1016/j.nano.2017.03.005	https://doi.org/10.1016/j.nano.2017.03.005	NOUN
admet-2756	412	16	[	[	X
admet-2756	412	17	58	58	NUM
admet-2756	412	18	]	]	PUNCT
admet-2756	412	19	a.r.k	a.r.k	X
admet-2756	412	20	.	.	PUNCT
admet-2756	412	21	sasikala	sasikala	PROPN
admet-2756	412	22	,	,	PUNCT
admet-2756	412	23	v.k	v.k	PROPN
admet-2756	412	24	.	.	PROPN
admet-2756	412	25	kaliannagounder	kaliannagounder	PROPN
admet-2756	412	26	,	,	PUNCT
admet-2756	412	27	n.r	n.r	PROPN
admet-2756	412	28	.	.	PROPN
admet-2756	412	29	alluri	alluri	PROPN
admet-2756	412	30	,	,	PUNCT
admet-2756	412	31	b.k	b.k	PROPN
admet-2756	412	32	.	.	PROPN
admet-2756	412	33	shrestha	shrestha	PROPN
admet-2756	412	34	,	,	PUNCT
admet-2756	412	35	s.j	s.j	PROPN
admet-2756	412	36	.	.	PROPN
admet-2756	412	37	kim	kim	PROPN
admet-2756	412	38	,	,	PUNCT
admet-2756	412	39	h.	h.	PROPN
admet-2756	412	40	ali	ali	PROPN
admet-2756	412	41	-	-	PUNCT
admet-2756	412	42	boucetta	boucetta	PROPN
admet-2756	412	43	,	,	PUNCT
admet-2756	412	44	c.h	c.h	PROPN
admet-2756	412	45	.	.	PROPN
admet-2756	412	46	park	park	PROPN
admet-2756	412	47	,	,	PUNCT
admet-2756	412	48	a.r	a.r	PROPN
admet-2756	412	49	.	.	PROPN
admet-2756	412	50	unnithan	unnithan	PROPN
admet-2756	412	51	.	.	PUNCT
admet-2756	413	1	development	development	NOUN
admet-2756	413	2	of	of	ADP
admet-2756	413	3	self	self	NOUN
admet-2756	413	4	-	-	PUNCT
admet-2756	413	5	powered	power	VERB
admet-2756	413	6	multifunctional	multifunctional	ADJ
admet-2756	413	7	piezomagnetic	piezomagnetic	ADJ
admet-2756	413	8	nanoparticles	nanoparticle	NOUN
admet-2756	413	9	for	for	ADP
admet-2756	413	10	noninvasive	noninvasive	ADJ
admet-2756	413	11	post	post	ADJ
admet-2756	413	12	-	-	ADJ
admet-2756	413	13	surgical	surgical	ADJ
admet-2756	413	14	osteosarcoma	osteosarcoma	ADJ
admet-2756	413	15	theranogeneration	theranogeneration	NOUN
admet-2756	413	16	.	.	PUNCT
admet-2756	414	1	nano	nano	NOUN
admet-2756	414	2	energy	energy	NOUN
admet-2756	414	3	96	96	NUM
admet-2756	414	4	(	(	PUNCT
admet-2756	414	5	2022	2022	NUM
admet-2756	414	6	)	)	PUNCT
admet-2756	414	7	107134	107134	NUM
admet-2756	414	8	https://doi.org/10.1016/j.nanoen.2022.107134	https://doi.org/10.1016/j.nanoen.2022.107134	VERB
admet-2756	414	9	[	[	X
admet-2756	414	10	59	59	NUM
admet-2756	414	11	]	]	X
admet-2756	414	12	y.	y.	PROPN
admet-2756	414	13	pan	pan	PROPN
admet-2756	414	14	j.	j.	PROPN
admet-2756	414	15	wang	wang	PROPN
admet-2756	414	16	,	,	PUNCT
admet-2756	414	17	z.	z.	PROPN
admet-2756	414	18	jiang	jiang	PROPN
admet-2756	414	19	,	,	PUNCT
admet-2756	414	20	q.	q.	PROPN
admet-2756	414	21	guo	guo	PROPN
admet-2756	414	22	,	,	PUNCT
admet-2756	414	23	z.	z.	PROPN
admet-2756	414	24	zhang	zhang	PROPN
admet-2756	414	25	,	,	PUNCT
admet-2756	414	26	j.	j.	PROPN
admet-2756	414	27	li	li	PROPN
admet-2756	414	28	,	,	PUNCT
admet-2756	414	29	y.	y.	PROPN
admet-2756	414	30	hu	hu	PROPN
admet-2756	414	31	,	,	PUNCT
admet-2756	414	32	l.	l.	PROPN
admet-2756	414	33	wang	wang	PROPN
admet-2756	414	34	.	.	PUNCT
admet-2756	415	1	zoledronate	zoledronate	PROPN
admet-2756	415	2	combined	combine	VERB
admet-2756	415	3	metal	metal	NOUN
admet-2756	415	4	-	-	PUNCT
admet-2756	415	5	organic	organic	ADJ
admet-2756	415	6	frameworks	framework	NOUN
admet-2756	415	7	for	for	ADP
admet-2756	415	8	bone	bone	NOUN
admet-2756	415	9	-	-	PUNCT
admet-2756	415	10	targeting	target	VERB
admet-2756	415	11	and	and	CCONJ
admet-2756	415	12	drugs	drug	NOUN
admet-2756	415	13	deliveries	delivery	NOUN
admet-2756	415	14	.	.	PUNCT
admet-2756	416	1	scientific	scientific	ADJ
admet-2756	416	2	reports	report	NOUN
admet-2756	416	3	12	12	NUM
admet-2756	416	4	(	(	PUNCT
admet-2756	416	5	2022	2022	NUM
admet-2756	416	6	)	)	PUNCT
admet-2756	416	7	12290	12290	NUM
admet-2756	417	1	https://doi.org/10.1038/s41598-022-15941-w	https://doi.org/10.1038/s41598-022-15941-w	NOUN
admet-2756	417	2	[	[	X
admet-2756	417	3	60	60	NUM
admet-2756	417	4	]	]	X
admet-2756	417	5	i.c	i.c	PROPN
admet-2756	417	6	.	.	PROPN
admet-2756	417	7	yoon	yoon	PROPN
admet-2756	417	8	,	,	PUNCT
admet-2756	417	9	l.	l.	PROPN
admet-2756	417	10	xue	xue	PROPN
admet-2756	417	11	,	,	PUNCT
admet-2756	417	12	q.	q.	PROPN
admet-2756	417	13	chen	chen	PROPN
admet-2756	417	14	,	,	PUNCT
admet-2756	417	15	j.	j.	PROPN
admet-2756	417	16	liu	liu	PROPN
admet-2756	417	17	,	,	PUNCT
admet-2756	417	18	j.	j.	PROPN
admet-2756	417	19	xu	xu	PROPN
admet-2756	417	20	,	,	PUNCT
admet-2756	417	21	z.	z.	PROPN
admet-2756	417	22	siddiqui	siddiqui	PROPN
admet-2756	417	23	,	,	PUNCT
admet-2756	417	24	d.	d.	PROPN
admet-2756	417	25	kim	kim	PROPN
admet-2756	417	26	,	,	PUNCT
admet-2756	417	27	b.	b.	PROPN
admet-2756	417	28	chen	chen	PROPN
admet-2756	417	29	,	,	PUNCT
admet-2756	417	30	q.	q.	PROPN
admet-2756	417	31	shi	shi	PROPN
admet-2756	417	32	,	,	PUNCT
admet-2756	417	33	e.	e.	PROPN
admet-2756	417	34	laura	laura	PROPN
admet-2756	417	35	han	han	PROPN
admet-2756	417	36	,	,	PUNCT
admet-2756	417	37	m.	m.	NOUN
admet-2756	417	38	cherry	cherry	PROPN
admet-2756	417	39	ruiz	ruiz	PROPN
admet-2756	417	40	.	.	PUNCT
admet-2756	418	1	piperazine	piperazine	NOUN
admet-2756	418	2	-	-	PUNCT
admet-2756	418	3	derived	derive	VERB
admet-2756	418	4	bisphosphonate	bisphosphonate	NOUN
admet-2756	418	5	-	-	PUNCT
admet-2756	418	6	based	base	VERB
admet-2756	418	7	ionizable	ionizable	ADJ
admet-2756	418	8	lipid	lipid	NOUN
admet-2756	418	9	nanoparticles	nanoparticle	NOUN
admet-2756	418	10	enhance	enhance	VERB
admet-2756	418	11	mrna	mrna	PROPN
admet-2756	418	12	delivery	delivery	NOUN
admet-2756	418	13	to	to	ADP
admet-2756	418	14	the	the	DET
admet-2756	418	15	bone	bone	NOUN
admet-2756	418	16	.	.	PUNCT
admet-2756	419	1	biomaterials	biomaterial	NOUN
admet-2756	419	2	64	64	NUM
admet-2756	419	3	(	(	PUNCT
admet-2756	419	4	2025	2025	NUM
admet-2756	419	5	)	)	PUNCT
admet-2756	419	6	https://doi.org/10.1002/anie.202415389	https://doi.org/10.1002/anie.202415389	NOUN
admet-2756	420	1	[	[	X
admet-2756	420	2	61	61	NUM
admet-2756	420	3	]	]	X
admet-2756	420	4	j.a	j.a	PROPN
admet-2756	420	5	.	.	PROPN
admet-2756	420	6	damasco	damasco	PROPN
admet-2756	420	7	,	,	PUNCT
admet-2756	420	8	g.	g.	PROPN
admet-2756	420	9	yu	yu	PROPN
admet-2756	420	10	,	,	PUNCT
admet-2756	420	11	a.	a.	PROPN
admet-2756	420	12	kumar	kumar	PROPN
admet-2756	420	13	,	,	PUNCT
admet-2756	420	14	j.	j.	PROPN
admet-2756	420	15	perez	perez	PROPN
admet-2756	420	16	,	,	PUNCT
admet-2756	420	17	r.c.m	r.c.m	NOUN
admet-2756	420	18	.	.	PUNCT
admet-2756	420	19	lirag	lirag	PROPN
admet-2756	420	20	,	,	PUNCT
admet-2756	420	21	e.m	e.m	PROPN
admet-2756	420	22	.	.	PROPN
admet-2756	420	23	whitley	whitley	PROPN
admet-2756	420	24	,	,	PUNCT
admet-2756	420	25	s.h	s.h	PROPN
admet-2756	420	26	.	.	PROPN
admet-2756	420	27	lin	lin	PROPN
admet-2756	420	28	,	,	PUNCT
admet-2756	421	1	m.p	m.p	PROPN
admet-2756	421	2	.	.	PROPN
admet-2756	421	3	melancon	melancon	PROPN
admet-2756	421	4	.	.	PUNCT
admet-2756	422	1	alendronate	alendronate	PROPN
admet-2756	422	2	conjugate	conjugate	ADJ
admet-2756	422	3	for	for	ADP
admet-2756	422	4	targeted	target	VERB
admet-2756	422	5	delivery	delivery	NOUN
admet-2756	422	6	to	to	ADP
admet-2756	422	7	bone	bone	NOUN
admet-2756	422	8	-	-	PUNCT
admet-2756	422	9	forming	form	VERB
admet-2756	422	10	prostate	prostate	NOUN
admet-2756	422	11	cancer	cancer	NOUN
admet-2756	422	12	.	.	PUNCT
admet-2756	423	1	talanta	talanta	PROPN
admet-2756	423	2	256	256	NUM
admet-2756	423	3	(	(	PUNCT
admet-2756	423	4	2023	2023	NUM
admet-2756	423	5	)	)	PUNCT
admet-2756	423	6	124308	124308	NUM
admet-2756	423	7	https://doi.org/10.1016/j.talanta.2023.124308	https://doi.org/10.1016/j.talanta.2023.124308	PROPN
admet-2756	423	8	https://doi.org/10.1016/j.jconrel.2019.12.043	https://doi.org/10.1016/j.jconrel.2019.12.043	NOUN
admet-2756	423	9	https://doi.org/10.1016/j.apsb.2020.06.006	https://doi.org/10.1016/j.apsb.2020.06.006	ADJ
admet-2756	423	10	https://doi.org/10.1021/bc500614b	https://doi.org/10.1021/bc500614b	NOUN
admet-2756	423	11	https://doi.org/10.1016/j.jddst.2024.106256	https://doi.org/10.1016/j.jddst.2024.106256	ADJ
admet-2756	423	12	https://doi.org/10.1038/srep36707	https://doi.org/10.1038/srep36707	NOUN
admet-2756	423	13	https://doi.org/10.1016/j.jddst.2018.02.004	https://doi.org/10.1016/j.jddst.2018.02.004	PROPN
admet-2756	423	14	https://doi.org/10.1038/s41598-020-72552-z	https://doi.org/10.1038/s41598-020-72552-z	ADP
admet-2756	423	15	https://doi.org/10.1016/j.nano.2019.102054	https://doi.org/10.1016/j.nano.2019.102054	PROPN
admet-2756	423	16	https://doi.org/10.1016/j.jconrel.2021.12.039	https://doi.org/10.1016/j.jconrel.2021.12.039	PROPN
admet-2756	423	17	https://doi.org/10.1016/j.biomaterials.2013.01.052	https://doi.org/10.1016/j.biomaterials.2013.01.052	PROPN
admet-2756	423	18	https://doi.org/10.1016/j.nano.2017.03.005	https://doi.org/10.1016/j.nano.2017.03.005	NUM
admet-2756	423	19	https://doi.org/10.1016/j.nanoen.2022.107134	https://doi.org/10.1016/j.nanoen.2022.107134	VERB
admet-2756	423	20	https://doi.org/10.1038/s41598-022-15941-w	https://doi.org/10.1038/s41598-022-15941-w	DET
admet-2756	423	21	https://doi.org/10.1002/anie.202415389	https://doi.org/10.1002/anie.202415389	NOUN
admet-2756	423	22	https://doi.org/10.1016/j.talanta.2023.124308	https://doi.org/10.1016/j.talanta.2023.124308	PROPN
admet-2756	423	23	admet	admet	PROPN
admet-2756	423	24	&	&	CCONJ
admet-2756	423	25	dmpk	dmpk	PROPN
admet-2756	423	26	13(3	13(3	NUM
admet-2756	423	27	)	)	PUNCT
admet-2756	423	28	(	(	PUNCT
admet-2756	423	29	2025	2025	NUM
admet-2756	423	30	)	)	PUNCT
admet-2756	423	31	2756	2756	NUM
admet-2756	423	32	bisphosphonates	bisphosphonate	NOUN
admet-2756	423	33	for	for	ADP
admet-2756	423	34	bone	bone	NOUN
admet-2756	423	35	cancer	cancer	NOUN
admet-2756	423	36	therapy	therapy	NOUN
admet-2756	423	37	doi	doi	NOUN
admet-2756	423	38	:	:	PUNCT
admet-2756	423	39	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	NOUN
admet-2756	423	40	17	17	NUM
admet-2756	424	1	[	[	SYM
admet-2756	424	2	62	62	NUM
admet-2756	424	3	]	]	PUNCT
admet-2756	424	4	a.	a.	NOUN
admet-2756	424	5	barbanente	barbanente	PROPN
admet-2756	424	6	,	,	PUNCT
admet-2756	424	7	a.m.	a.m.	PROPN
admet-2756	424	8	di	di	PROPN
admet-2756	424	9	cosola	cosola	PROPN
admet-2756	424	10	,	,	PUNCT
admet-2756	424	11	m.	m.	NOUN
admet-2756	424	12	niso	niso	PROPN
admet-2756	424	13	,	,	PUNCT
admet-2756	424	14	l.	l.	PROPN
admet-2756	424	15	d'anna	d'anna	PROPN
admet-2756	424	16	,	,	PUNCT
admet-2756	424	17	s.	s.	PROPN
admet-2756	424	18	rubino	rubino	PROPN
admet-2756	424	19	,	,	PUNCT
admet-2756	424	20	s.	s.	PROPN
admet-2756	424	21	indelicato	indelicato	PROPN
admet-2756	424	22	,	,	PUNCT
admet-2756	424	23	c.	c.	PROPN
admet-2756	424	24	pacifico	pacifico	PROPN
admet-2756	424	25	,	,	PUNCT
admet-2756	424	26	a.	a.	NOUN
admet-2756	424	27	terenzi	terenzi	PROPN
admet-2756	424	28	,	,	PUNCT
admet-2756	424	29	n.	n.	PROPN
admet-2756	424	30	margiotta	margiotta	PROPN
admet-2756	424	31	.	.	PUNCT
admet-2756	425	1	new	new	ADJ
admet-2756	425	2	oxaliplatin	oxaliplatin	PROPN
admet-2756	425	3	-	-	PUNCT
admet-2756	425	4	zoledronate	zoledronate	ADJ
admet-2756	425	5	derivatives	derivative	NOUN
admet-2756	425	6	with	with	ADP
admet-2756	425	7	potential	potential	ADJ
admet-2756	425	8	antitumor	antitumor	NOUN
admet-2756	425	9	activity	activity	NOUN
admet-2756	425	10	towards	towards	ADP
admet-2756	425	11	bone	bone	NOUN
admet-2756	425	12	tumors	tumor	NOUN
admet-2756	425	13	and	and	CCONJ
admet-2756	425	14	metastases	metastasis	NOUN
admet-2756	425	15	.	.	PUNCT
admet-2756	426	1	journal	journal	PROPN
admet-2756	426	2	of	of	ADP
admet-2756	426	3	inorganic	inorganic	ADJ
admet-2756	426	4	biochemistry	biochemistry	NOUN
admet-2756	426	5	270	270	NUM
admet-2756	426	6	(	(	PUNCT
admet-2756	426	7	2025	2025	NUM
admet-2756	426	8	)	)	PUNCT
admet-2756	426	9	112916	112916	NUM
admet-2756	426	10	https://doi.org/10.1016/j.jinorgbio.2025.112916	https://doi.org/10.1016/j.jinorgbio.2025.112916	PROPN
admet-2756	426	11	©	©	PROPN
admet-2756	426	12	2025	2025	NUM
admet-2756	426	13	by	by	ADP
admet-2756	426	14	the	the	DET
admet-2756	426	15	authors	author	NOUN
admet-2756	426	16	;	;	PUNCT
admet-2756	426	17	licensee	licensee	PROPN
admet-2756	426	18	iapc	iapc	PROPN
admet-2756	426	19	,	,	PUNCT
admet-2756	426	20	zagreb	zagreb	PROPN
admet-2756	426	21	,	,	PUNCT
admet-2756	426	22	croatia	croatia	PROPN
admet-2756	426	23	.	.	PUNCT
admet-2756	427	1	this	this	DET
admet-2756	427	2	article	article	NOUN
admet-2756	427	3	is	be	AUX
admet-2756	427	4	an	an	DET
admet-2756	427	5	open	open	ADJ
admet-2756	427	6	-	-	PUNCT
admet-2756	427	7	access	access	NOUN
admet-2756	427	8	article	article	NOUN
admet-2756	427	9	distributed	distribute	VERB
admet-2756	427	10	under	under	ADP
admet-2756	427	11	the	the	DET
admet-2756	427	12	terms	term	NOUN
admet-2756	427	13	and	and	CCONJ
admet-2756	427	14	conditions	condition	NOUN
admet-2756	427	15	of	of	ADP
admet-2756	427	16	the	the	DET
admet-2756	427	17	creative	creative	ADJ
admet-2756	427	18	commons	common	NOUN
admet-2756	427	19	attribution	attribution	NOUN
admet-2756	427	20	license	license	NOUN
admet-2756	427	21	(	(	PUNCT
admet-2756	427	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2756	427	23	)	)	PUNCT
admet-2756	427	24	https://doi.org/10.5599/admet.2756	https://doi.org/10.5599/admet.2756	PROPN
admet-2756	427	25	https://doi.org/10.1016/j.jinorgbio.2025.112916	https://doi.org/10.1016/j.jinorgbio.2025.112916	PROPN
admet-2756	427	26	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN