id	sid	tid	token	lemma	pos
admet-276	1	1	manuscript	manuscript	PROPN
admet-276	1	2	doi	doi	PROPN
admet-276	1	3	:	:	PUNCT
admet-276	1	4	10.5599	10.5599	NUM
admet-276	1	5	/	/	SYM
admet-276	1	6	admet.4.1.276	admet.4.1.276	NUM
admet-276	1	7	1	1	NUM
admet-276	1	8	admet	admet	X
admet-276	1	9	&	&	CCONJ
admet-276	1	10	dmpk	dmpk	PROPN
admet-276	1	11	4(1	4(1	NOUN
admet-276	1	12	)	)	PUNCT
admet-276	1	13	(	(	PUNCT
admet-276	1	14	2016	2016	NUM
admet-276	1	15	)	)	PUNCT
admet-276	1	16	1	1	NUM
admet-276	1	17	-	-	SYM
admet-276	1	18	22	22	NUM
admet-276	1	19	;	;	PUNCT
admet-276	1	20	doi	doi	NOUN
admet-276	1	21	:	:	PUNCT
admet-276	1	22	10.5599	10.5599	NUM
admet-276	1	23	/	/	SYM
admet-276	1	24	admet.4.1.276	admet.4.1.276	NOUN
admet-276	1	25	open	open	ADJ
admet-276	1	26	access	access	NOUN
admet-276	1	27	:	:	PUNCT
admet-276	1	28	issn	issn	PROPN
admet-276	1	29	:	:	PUNCT
admet-276	1	30	1848	1848	NUM
admet-276	1	31	-	-	SYM
admet-276	1	32	7718	7718	NUM
admet-276	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-276	1	34	review	review	VERB
admet-276	1	35	an	an	DET
admet-276	1	36	overall	overall	ADJ
admet-276	1	37	comparison	comparison	NOUN
admet-276	1	38	of	of	ADP
admet-276	1	39	small	small	ADJ
admet-276	1	40	molecules	molecule	NOUN
admet-276	1	41	and	and	CCONJ
admet-276	1	42	large	large	ADJ
admet-276	1	43	biologics	biologic	NOUN
admet-276	1	44	in	in	ADP
admet-276	1	45	adme	adme	NOUN
admet-276	1	46	testing	test	VERB
admet-276	1	47	hong	hong	PROPN
admet-276	1	48	wan	wan	PROPN
admet-276	1	49	shanghai	shanghai	PROPN
admet-276	1	50	hengrui	hengrui	PROPN
admet-276	1	51	pharmaceutical	pharmaceutical	PROPN
admet-276	1	52	co.	co.	PROPN
admet-276	1	53	,	,	PUNCT
admet-276	1	54	ltd	ltd	PROPN
admet-276	1	55	.	.	PROPN
admet-276	1	56	dept	dept	PROPN
admet-276	1	57	.	.	PROPN
admet-276	2	1	of	of	ADP
admet-276	2	2	dmpk	dmpk	PROPN
admet-276	2	3	/	/	SYM
admet-276	2	4	tox	tox	PROPN
admet-276	2	5	,	,	PUNCT
admet-276	2	6	shanghai	shanghai	PROPN
admet-276	2	7	,	,	PUNCT
admet-276	2	8	p.r	p.r	PROPN
admet-276	2	9	.	.	PROPN
admet-276	2	10	china	china	PROPN
admet-276	2	11	e	e	PROPN
admet-276	2	12	-	-	NOUN
admet-276	2	13	mail	mail	NOUN
admet-276	2	14	:	:	PUNCT
admet-276	2	15	wanh@shhrp.com	wanh@shhrp.com	PROPN
admet-276	2	16	;	;	PUNCT
admet-276	2	17	tel	tel	PROPN
admet-276	2	18	.	.	PUNCT
admet-276	2	19	:	:	PUNCT
admet-276	2	20	+86(0)21	+86(0)21	ADJ
admet-276	2	21	-	-	PUNCT
admet-276	2	22	54759066	54759066	NUM
admet-276	2	23	-	-	SYM
admet-276	2	24	1313	1313	NUM
admet-276	2	25	received	receive	VERB
admet-276	2	26	:	:	PUNCT
admet-276	2	27	march	march	PROPN
admet-276	2	28	12	12	NUM
admet-276	2	29	,	,	PUNCT
admet-276	2	30	2016	2016	NUM
admet-276	2	31	;	;	PUNCT
admet-276	2	32	revised	revise	VERB
admet-276	2	33	:	:	PUNCT
admet-276	2	34	march	march	PROPN
admet-276	2	35	23	23	NUM
admet-276	2	36	;	;	PUNCT
admet-276	2	37	published	publish	VERB
admet-276	2	38	:	:	PUNCT
admet-276	2	39	march	march	PROPN
admet-276	2	40	31	31	NUM
admet-276	2	41	,	,	PUNCT
admet-276	2	42	2016	2016	NUM
admet-276	2	43	abstract	abstract	ADJ
admet-276	2	44	biologics	biologic	NOUN
admet-276	2	45	mainly	mainly	ADV
admet-276	2	46	monoclonal	monoclonal	NOUN
admet-276	2	47	antibodies	antibody	NOUN
admet-276	2	48	(	(	PUNCT
admet-276	2	49	mabs	mab	NOUN
admet-276	2	50	)	)	PUNCT
admet-276	2	51	and	and	CCONJ
admet-276	2	52	antibody	antibody	NOUN
admet-276	2	53	-	-	PUNCT
admet-276	2	54	drug	drug	NOUN
admet-276	2	55	conjugates	conjugate	NOUN
admet-276	2	56	(	(	PUNCT
admet-276	2	57	adcs	adcs	ADJ
admet-276	2	58	)	)	PUNCT
admet-276	2	59	as	as	SCONJ
admet-276	2	60	new	new	ADJ
admet-276	2	61	therapeutics	therapeutic	NOUN
admet-276	2	62	are	be	AUX
admet-276	2	63	becoming	become	VERB
admet-276	2	64	increasingly	increasingly	ADV
admet-276	2	65	important	important	ADJ
admet-276	2	66	biotherapeutics	biotherapeutic	NOUN
admet-276	2	67	.	.	PUNCT
admet-276	3	1	this	this	DET
admet-276	3	2	review	review	NOUN
admet-276	3	3	is	be	AUX
admet-276	3	4	intended	intend	VERB
admet-276	3	5	to	to	PART
admet-276	3	6	provide	provide	VERB
admet-276	3	7	an	an	DET
admet-276	3	8	overall	overall	ADJ
admet-276	3	9	comparison	comparison	NOUN
admet-276	3	10	between	between	ADP
admet-276	3	11	small	small	ADJ
admet-276	3	12	molecules	molecule	NOUN
admet-276	3	13	(	(	PUNCT
admet-276	3	14	sms	sms	PROPN
admet-276	3	15	)	)	PUNCT
admet-276	3	16	and	and	CCONJ
admet-276	3	17	biologics	biologic	NOUN
admet-276	3	18	or	or	CCONJ
admet-276	3	19	large	large	ADJ
admet-276	3	20	molecules	molecule	NOUN
admet-276	3	21	(	(	PUNCT
admet-276	3	22	lms	lm	NOUN
admet-276	3	23	)	)	PUNCT
admet-276	3	24	concerning	concern	VERB
admet-276	3	25	drug	drug	NOUN
admet-276	3	26	metabolism	metabolism	NOUN
admet-276	3	27	and	and	CCONJ
admet-276	3	28	pharmacokinetic	pharmacokinetic	ADJ
admet-276	3	29	(	(	PUNCT
admet-276	3	30	dmpk	dmpk	NOUN
admet-276	3	31	)	)	PUNCT
admet-276	3	32	or	or	CCONJ
admet-276	3	33	associated	associate	VERB
admet-276	3	34	with	with	ADP
admet-276	3	35	absorption	absorption	NOUN
admet-276	3	36	,	,	PUNCT
admet-276	3	37	distribution	distribution	NOUN
admet-276	3	38	,	,	PUNCT
admet-276	3	39	metabolism	metabolism	NOUN
admet-276	3	40	and	and	CCONJ
admet-276	3	41	elimination	elimination	NOUN
admet-276	3	42	(	(	PUNCT
admet-276	3	43	adme	adme	NOUN
admet-276	3	44	)	)	PUNCT
admet-276	3	45	testing	testing	NOUN
admet-276	3	46	from	from	ADP
admet-276	3	47	pharmaceutical	pharmaceutical	NOUN
admet-276	3	48	industry	industry	NOUN
admet-276	3	49	drug	drug	NOUN
admet-276	3	50	discovery	discovery	NOUN
admet-276	3	51	and	and	CCONJ
admet-276	3	52	development	development	NOUN
admet-276	3	53	points	point	NOUN
admet-276	3	54	of	of	ADP
admet-276	3	55	view	view	NOUN
admet-276	3	56	,	,	PUNCT
admet-276	3	57	which	which	PRON
admet-276	3	58	will	will	AUX
admet-276	3	59	help	help	VERB
admet-276	3	60	design	design	VERB
admet-276	3	61	and	and	CCONJ
admet-276	3	62	conduct	conduct	VERB
admet-276	3	63	relevant	relevant	ADJ
admet-276	3	64	adme	adme	NOUN
admet-276	3	65	testing	testing	NOUN
admet-276	3	66	for	for	ADP
admet-276	3	67	biologics	biologic	NOUN
admet-276	3	68	such	such	ADJ
admet-276	3	69	as	as	ADP
admet-276	3	70	mabs	mab	NOUN
admet-276	3	71	and	and	CCONJ
admet-276	3	72	adcs	adc	NOUN
admet-276	3	73	.	.	PUNCT
admet-276	4	1	recent	recent	ADJ
admet-276	4	2	advancements	advancement	NOUN
admet-276	4	3	in	in	ADP
admet-276	4	4	the	the	DET
admet-276	4	5	adme	adme	NOUN
admet-276	4	6	for	for	ADP
admet-276	4	7	testing	testing	NOUN
admet-276	4	8	biologics	biologic	NOUN
admet-276	4	9	and	and	CCONJ
admet-276	4	10	related	related	ADJ
admet-276	4	11	bioanalytical	bioanalytical	ADJ
admet-276	4	12	methods	method	NOUN
admet-276	4	13	are	be	AUX
admet-276	4	14	discussed	discuss	VERB
admet-276	4	15	with	with	ADP
admet-276	4	16	an	an	DET
admet-276	4	17	emphasis	emphasis	NOUN
admet-276	4	18	on	on	ADP
admet-276	4	19	adc	adc	PROPN
admet-276	4	20	drug	drug	NOUN
admet-276	4	21	development	development	NOUN
admet-276	4	22	as	as	ADP
admet-276	4	23	an	an	DET
admet-276	4	24	example	example	NOUN
admet-276	4	25	to	to	PART
admet-276	4	26	understand	understand	VERB
admet-276	4	27	its	its	PRON
admet-276	4	28	complexity	complexity	NOUN
admet-276	4	29	and	and	CCONJ
admet-276	4	30	challenges	challenge	NOUN
admet-276	4	31	from	from	ADP
admet-276	4	32	extensive	extensive	ADJ
admet-276	4	33	in	in	ADP
admet-276	4	34	vitro	vitro	X
admet-276	4	35	characterization	characterization	NOUN
admet-276	4	36	to	to	ADP
admet-276	4	37	in	in	ADP
admet-276	4	38	vivo	vivo	NOUN
admet-276	4	39	animal	animal	NOUN
admet-276	4	40	pk	pk	NOUN
admet-276	4	41	studies	study	NOUN
admet-276	4	42	.	.	PUNCT
admet-276	5	1	general	general	ADJ
admet-276	5	2	non	non	ADJ
admet-276	5	3	-	-	ADJ
admet-276	5	4	clinical	clinical	ADJ
admet-276	5	5	safety	safety	NOUN
admet-276	5	6	evaluations	evaluation	NOUN
admet-276	5	7	of	of	ADP
admet-276	5	8	biologics	biologic	NOUN
admet-276	5	9	in	in	ADP
admet-276	5	10	particular	particular	ADJ
admet-276	5	11	for	for	ADP
admet-276	5	12	adc	adc	PROPN
admet-276	5	13	drugs	drug	NOUN
admet-276	5	14	are	be	AUX
admet-276	5	15	outlined	outline	VERB
admet-276	5	16	including	include	VERB
admet-276	5	17	drug	drug	NOUN
admet-276	5	18	-	-	PUNCT
admet-276	5	19	drug	drug	NOUN
admet-276	5	20	interaction	interaction	NOUN
admet-276	5	21	(	(	PUNCT
admet-276	5	22	ddi	ddi	PROPN
admet-276	5	23	)	)	PUNCT
admet-276	5	24	and	and	CCONJ
admet-276	5	25	metabolite	metabolite	NOUN
admet-276	5	26	/	/	SYM
admet-276	5	27	catabolite	catabolite	ADJ
admet-276	5	28	assessments	assessment	NOUN
admet-276	5	29	.	.	PUNCT
admet-276	6	1	regulatory	regulatory	ADJ
admet-276	6	2	guidance	guidance	NOUN
admet-276	6	3	on	on	ADP
admet-276	6	4	the	the	DET
admet-276	6	5	adme	adme	NOUN
admet-276	6	6	testing	testing	NOUN
admet-276	6	7	and	and	CCONJ
admet-276	6	8	safety	safety	NOUN
admet-276	6	9	evaluations	evaluation	NOUN
admet-276	6	10	including	include	VERB
admet-276	6	11	immunogenicity	immunogenicity	NOUN
admet-276	6	12	as	as	ADV
admet-276	6	13	well	well	ADV
admet-276	6	14	as	as	ADP
admet-276	6	15	bioanalytical	bioanalytical	ADJ
admet-276	6	16	considerations	consideration	NOUN
admet-276	6	17	are	be	AUX
admet-276	6	18	addressed	address	VERB
admet-276	6	19	for	for	ADP
admet-276	6	20	lms	lm	NOUN
admet-276	6	21	.	.	PUNCT
admet-276	7	1	in	in	ADP
admet-276	7	2	addition	addition	NOUN
admet-276	7	3	,	,	PUNCT
admet-276	7	4	the	the	DET
admet-276	7	5	preclinical	preclinical	ADJ
admet-276	7	6	and	and	CCONJ
admet-276	7	7	human	human	ADJ
admet-276	7	8	pk	pk	NOUN
admet-276	7	9	data	datum	NOUN
admet-276	7	10	of	of	ADP
admet-276	7	11	two	two	NUM
admet-276	7	12	marked	mark	VERB
admet-276	7	13	adc	adc	PROPN
admet-276	7	14	drugs	drug	NOUN
admet-276	7	15	(	(	PUNCT
admet-276	7	16	adcetris	adcetris	VERB
admet-276	7	17	,	,	PUNCT
admet-276	7	18	sgn-35	sgn-35	ADV
admet-276	7	19	and	and	CCONJ
admet-276	7	20	kadcyla	kadcyla	NOUN
admet-276	7	21	,	,	PUNCT
admet-276	7	22	t	t	PROPN
admet-276	7	23	-	-	PUNCT
admet-276	7	24	dm1	dm1	NOUN
admet-276	7	25	)	)	PUNCT
admet-276	7	26	as	as	SCONJ
admet-276	7	27	examples	example	NOUN
admet-276	7	28	are	be	AUX
admet-276	7	29	briefly	briefly	ADV
admet-276	7	30	discussed	discuss	VERB
admet-276	7	31	with	with	ADP
admet-276	7	32	regard	regard	NOUN
admet-276	7	33	to	to	ADP
admet-276	7	34	pk	pk	NOUN
admet-276	7	35	considerations	consideration	NOUN
admet-276	7	36	and	and	CCONJ
admet-276	7	37	pk	pk	NOUN
admet-276	7	38	/	/	SYM
admet-276	7	39	pd	pd	NOUN
admet-276	7	40	perspectives	perspective	NOUN
admet-276	7	41	.	.	PUNCT
admet-276	8	1	keywords	keyword	VERB
admet-276	8	2	monoclonal	monoclonal	NOUN
admet-276	8	3	antibody	antibody	NOUN
admet-276	8	4	;	;	PUNCT
admet-276	8	5	antibody	antibody	NOUN
admet-276	8	6	-	-	PUNCT
admet-276	8	7	drug	drug	NOUN
admet-276	8	8	conjugate	conjugate	NOUN
admet-276	8	9	;	;	PUNCT
admet-276	8	10	pharmacokinetics	pharmacokinetic	NOUN
admet-276	8	11	;	;	PUNCT
admet-276	8	12	bioanalysis	bioanalysis	NOUN
admet-276	8	13	;	;	PUNCT
admet-276	8	14	preclinical	preclinical	ADJ
admet-276	8	15	safety	safety	NOUN
admet-276	8	16	1	1	NUM
admet-276	8	17	.	.	PUNCT
admet-276	9	1	introduction	introduction	NOUN
admet-276	9	2	biologics	biologic	NOUN
admet-276	9	3	or	or	CCONJ
admet-276	9	4	large	large	ADJ
admet-276	9	5	molecules	molecule	NOUN
admet-276	9	6	(	(	PUNCT
admet-276	9	7	lms	lm	NOUN
admet-276	9	8	)	)	PUNCT
admet-276	9	9	primarily	primarily	ADV
admet-276	9	10	monoclonal	monoclonal	NOUN
admet-276	9	11	antibodies	antibody	NOUN
admet-276	9	12	(	(	PUNCT
admet-276	9	13	mabs	mab	NOUN
admet-276	9	14	)	)	PUNCT
admet-276	9	15	and	and	CCONJ
admet-276	9	16	antibody	antibody	NOUN
admet-276	9	17	-	-	PUNCT
admet-276	9	18	drug	drug	NOUN
admet-276	9	19	conjugate	conjugate	NOUN
admet-276	9	20	(	(	PUNCT
admet-276	9	21	adc	adc	PROPN
admet-276	9	22	)	)	PUNCT
admet-276	9	23	currently	currently	ADV
admet-276	9	24	represent	represent	VERB
admet-276	9	25	main	main	ADJ
admet-276	9	26	stream	stream	NOUN
admet-276	9	27	therapeutics	therapeutic	NOUN
admet-276	9	28	and	and	CCONJ
admet-276	9	29	continue	continue	VERB
admet-276	9	30	to	to	PART
admet-276	9	31	grow	grow	VERB
admet-276	9	32	in	in	ADP
admet-276	9	33	number	number	NOUN
admet-276	9	34	of	of	ADP
admet-276	9	35	new	new	ADJ
admet-276	9	36	approvals	approval	NOUN
admet-276	9	37	and	and	CCONJ
admet-276	9	38	targets	target	NOUN
admet-276	9	39	recently	recently	ADV
admet-276	9	40	[	[	X
admet-276	9	41	1	1	NUM
admet-276	9	42	-	-	SYM
admet-276	9	43	4	4	NUM
admet-276	9	44	]	]	PUNCT
admet-276	9	45	.	.	PUNCT
admet-276	10	1	a	a	DET
admet-276	10	2	majority	majority	NOUN
admet-276	10	3	of	of	ADP
admet-276	10	4	these	these	DET
admet-276	10	5	biotherapeutics	biotherapeutic	NOUN
admet-276	10	6	are	be	AUX
admet-276	10	7	mabs	mab	NOUN
admet-276	10	8	or	or	CCONJ
admet-276	10	9	mab	mab	NOUN
admet-276	10	10	-	-	PUNCT
admet-276	10	11	derived	derive	VERB
admet-276	10	12	proteins	protein	NOUN
admet-276	10	13	,	,	PUNCT
admet-276	10	14	which	which	PRON
admet-276	10	15	are	be	AUX
admet-276	10	16	subject	subject	ADJ
admet-276	10	17	to	to	ADP
admet-276	10	18	transformation	transformation	NOUN
admet-276	10	19	mechanisms	mechanism	NOUN
admet-276	10	20	such	such	ADJ
admet-276	10	21	as	as	ADP
admet-276	10	22	deamidation	deamidation	NOUN
admet-276	10	23	,	,	PUNCT
admet-276	10	24	oxidation	oxidation	NOUN
admet-276	10	25	,	,	PUNCT
admet-276	10	26	and	and	CCONJ
admet-276	10	27	isomerization	isomerization	NOUN
admet-276	10	28	[	[	X
admet-276	10	29	1	1	NUM
admet-276	10	30	-	-	SYM
admet-276	10	31	4	4	NUM
admet-276	10	32	]	]	PUNCT
admet-276	10	33	.	.	PUNCT
admet-276	11	1	these	these	DET
admet-276	11	2	processes	process	NOUN
admet-276	11	3	usually	usually	ADV
admet-276	11	4	result	result	VERB
admet-276	11	5	in	in	ADP
admet-276	11	6	relatively	relatively	ADV
admet-276	11	7	small	small	ADJ
admet-276	11	8	structural	structural	ADJ
admet-276	11	9	changes	change	NOUN
admet-276	11	10	in	in	ADP
admet-276	11	11	the	the	DET
admet-276	11	12	parent	parent	NOUN
admet-276	11	13	drugs	drug	NOUN
admet-276	11	14	.	.	PUNCT
admet-276	12	1	such	such	ADJ
admet-276	12	2	small	small	ADJ
admet-276	12	3	structural	structural	ADJ
admet-276	12	4	changes	change	NOUN
admet-276	12	5	may	may	AUX
admet-276	12	6	be	be	AUX
admet-276	12	7	difficult	difficult	ADJ
admet-276	12	8	for	for	SCONJ
admet-276	12	9	a	a	DET
admet-276	12	10	conventional	conventional	ADJ
admet-276	12	11	immunoassay	immunoassay	NOUN
admet-276	12	12	to	to	PART
admet-276	12	13	differentiate	differentiate	VERB
admet-276	12	14	,	,	PUNCT
admet-276	12	15	but	but	CCONJ
admet-276	12	16	they	they	PRON
admet-276	12	17	can	can	AUX
admet-276	12	18	still	still	ADV
admet-276	12	19	affect	affect	VERB
admet-276	12	20	biological	biological	ADJ
admet-276	12	21	activity	activity	NOUN
admet-276	12	22	,	,	PUNCT
admet-276	12	23	pk	pk	NOUN
admet-276	12	24	and	and	CCONJ
admet-276	12	25	immunogenicity	immunogenicity	NOUN
admet-276	12	26	of	of	ADP
admet-276	12	27	a	a	DET
admet-276	12	28	therapeutic	therapeutic	ADJ
admet-276	12	29	protein	protein	NOUN
admet-276	12	30	[	[	X
admet-276	12	31	5	5	NUM
admet-276	12	32	]	]	PUNCT
admet-276	12	33	.	.	PUNCT
admet-276	13	1	whereas	whereas	SCONJ
admet-276	13	2	adcs	adc	NOUN
admet-276	13	3	are	be	AUX
admet-276	13	4	an	an	DET
admet-276	13	5	emerging	emerge	VERB
admet-276	13	6	class	class	NOUN
admet-276	13	7	of	of	ADP
admet-276	13	8	biotherapeutics	biotherapeutic	NOUN
admet-276	13	9	that	that	PRON
admet-276	13	10	combines	combine	VERB
admet-276	13	11	the	the	DET
admet-276	13	12	target	target	NOUN
admet-276	13	13	specificity	specificity	NOUN
admet-276	13	14	of	of	ADP
admet-276	13	15	an	an	DET
admet-276	13	16	antibody	antibody	NOUN
admet-276	13	17	with	with	ADP
admet-276	13	18	the	the	DET
admet-276	13	19	potent	potent	ADJ
admet-276	13	20	small	small	ADJ
admet-276	13	21	-	-	PUNCT
admet-276	13	22	molecule	molecule	NOUN
admet-276	13	23	drugs	drug	NOUN
admet-276	13	24	or	or	CCONJ
admet-276	13	25	cytotoxins	cytotoxin	NOUN
admet-276	13	26	,	,	PUNCT
admet-276	13	27	which	which	PRON
admet-276	13	28	can	can	AUX
admet-276	13	29	selectively	selectively	ADV
admet-276	13	30	deliver	deliver	VERB
admet-276	13	31	a	a	DET
admet-276	13	32	potent	potent	ADJ
admet-276	13	33	cytotoxic	cytotoxic	ADJ
admet-276	13	34	drug	drug	NOUN
admet-276	13	35	to	to	ADP
admet-276	13	36	tumor	tumor	NOUN
admet-276	13	37	cells	cell	NOUN
admet-276	13	38	via	via	ADP
admet-276	13	39	tumor	tumor	NOUN
admet-276	13	40	-	-	PUNCT
admet-276	13	41	specific	specific	ADJ
admet-276	13	42	and/or	and/or	CCONJ
admet-276	13	43	over	over	ADV
admet-276	13	44	-	-	PUNCT
admet-276	13	45	expressed	express	VERB
admet-276	13	46	antigens	antigen	NOUN
admet-276	13	47	with	with	ADP
admet-276	13	48	more	more	ADV
admet-276	13	49	favorable	favorable	ADJ
admet-276	13	50	therapeutic	therapeutic	ADJ
admet-276	13	51	window	window	NOUN
admet-276	13	52	[	[	X
admet-276	13	53	1,6	1,6	NUM
admet-276	13	54	]	]	PUNCT
admet-276	13	55	.	.	PUNCT
admet-276	14	1	this	this	DET
admet-276	14	2	new	new	ADJ
admet-276	14	3	type	type	NOUN
admet-276	14	4	of	of	ADP
admet-276	14	5	antibody	antibody	NOUN
admet-276	14	6	-	-	PUNCT
admet-276	14	7	drug	drug	NOUN
admet-276	14	8	conjugate	conjugate	NOUN
admet-276	14	9	or	or	CCONJ
admet-276	14	10	antibody	antibody	NOUN
admet-276	14	11	-	-	PUNCT
admet-276	14	12	linker	linker	NOUN
admet-276	14	13	-	-	PUNCT
admet-276	14	14	drug	drug	NOUN
admet-276	14	15	currently	currently	ADV
admet-276	14	16	shows	show	VERB
admet-276	14	17	its	its	PRON
admet-276	14	18	great	great	ADJ
admet-276	14	19	promising	promising	ADJ
admet-276	14	20	therapeutic	therapeutic	ADJ
admet-276	14	21	options	option	NOUN
admet-276	14	22	,	,	PUNCT
admet-276	14	23	which	which	PRON
admet-276	14	24	led	lead	VERB
admet-276	14	25	to	to	ADP
admet-276	14	26	the	the	DET
admet-276	14	27	recent	recent	ADJ
admet-276	14	28	fda	fda	PROPN
admet-276	14	29	approvals	approval	NOUN
admet-276	14	30	of	of	ADP
admet-276	14	31	adcetris	adcetris	NOUN
admet-276	14	32	(	(	PUNCT
admet-276	14	33	brentuximab	brentuximab	NOUN
admet-276	14	34	vedotin	vedotin	NOUN
admet-276	14	35	,	,	PUNCT
admet-276	14	36	sgn-35	sgn-35	PRON
admet-276	14	37	)	)	PUNCT
admet-276	14	38	and	and	CCONJ
admet-276	14	39	kadcyla	kadcyla	NOUN
admet-276	14	40	(	(	PUNCT
admet-276	14	41	ado	ado	NOUN
admet-276	14	42	-	-	PUNCT
admet-276	14	43	trastuzumab	trastuzumab	NOUN
admet-276	14	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-276	14	45	hong	hong	PROPN
admet-276	14	46	wan	wan	PROPN
admet-276	14	47	admet	admet	PROPN
admet-276	14	48	&	&	CCONJ
admet-276	14	49	dmpk	dmpk	PROPN
admet-276	14	50	4(1	4(1	NOUN
admet-276	14	51	)	)	PUNCT
admet-276	14	52	(	(	PUNCT
admet-276	14	53	2016	2016	NUM
admet-276	14	54	)	)	PUNCT
admet-276	14	55	1	1	NUM
admet-276	14	56	-	-	SYM
admet-276	14	57	22	22	NUM
admet-276	14	58	2	2	NUM
admet-276	14	59	emtansine	emtansine	NOUN
admet-276	14	60	,	,	PUNCT
admet-276	14	61	t	t	PROPN
admet-276	14	62	-	-	PUNCT
admet-276	14	63	dm1	dm1	NOUN
admet-276	14	64	)	)	PUNCT
admet-276	14	65	for	for	ADP
admet-276	14	66	the	the	DET
admet-276	14	67	treatment	treatment	NOUN
admet-276	14	68	of	of	ADP
admet-276	14	69	hodgkin	hodgkin	PROPN
admet-276	14	70	’s	’s	PART
admet-276	14	71	lymphoma	lymphoma	NOUN
admet-276	14	72	(	(	PUNCT
admet-276	14	73	hl	hl	NOUN
admet-276	14	74	)	)	PUNCT
admet-276	14	75	and	and	CCONJ
admet-276	14	76	anaplastic	anaplastic	ADJ
admet-276	14	77	large	large	ADJ
admet-276	14	78	-	-	PUNCT
admet-276	14	79	cell	cell	NOUN
admet-276	14	80	lymphomas	lymphoma	NOUN
admet-276	14	81	(	(	PUNCT
admet-276	14	82	alcl	alcl	NOUN
admet-276	14	83	)	)	PUNCT
admet-276	14	84	,	,	PUNCT
admet-276	14	85	and	and	CCONJ
admet-276	14	86	her2	her2	PROPN
admet-276	14	87	-	-	PUNCT
admet-276	14	88	positive	positive	ADJ
admet-276	14	89	metastatic	metastatic	ADJ
admet-276	14	90	breast	breast	NOUN
admet-276	14	91	cancer	cancer	NOUN
admet-276	14	92	,	,	PUNCT
admet-276	14	93	respectively	respectively	ADV
admet-276	14	94	,	,	PUNCT
admet-276	14	95	as	as	ADV
admet-276	14	96	well	well	ADV
admet-276	14	97	as	as	ADP
admet-276	14	98	a	a	DET
admet-276	14	99	rich	rich	ADJ
admet-276	14	100	clinical	clinical	ADJ
admet-276	14	101	pipeline	pipeline	NOUN
admet-276	14	102	of	of	ADP
admet-276	14	103	potential	potential	ADJ
admet-276	14	104	new	new	ADJ
admet-276	14	105	cancer	cancer	NOUN
admet-276	14	106	therapies	therapy	NOUN
admet-276	14	107	[	[	X
admet-276	14	108	7	7	NUM
admet-276	14	109	]	]	PUNCT
admet-276	14	110	.	.	PUNCT
admet-276	15	1	throughout	throughout	ADP
admet-276	15	2	several	several	ADJ
admet-276	15	3	decades	decade	NOUN
admet-276	15	4	of	of	ADP
admet-276	15	5	advancements	advancement	NOUN
admet-276	15	6	and	and	CCONJ
admet-276	15	7	evolutions	evolution	NOUN
admet-276	15	8	,	,	PUNCT
admet-276	15	9	admet	admet	NOUN
admet-276	15	10	profiling	profiling	NOUN
admet-276	15	11	of	of	ADP
admet-276	15	12	small	small	ADJ
admet-276	15	13	molecule	molecule	NOUN
admet-276	15	14	(	(	PUNCT
admet-276	15	15	sm	sm	X
admet-276	15	16	)	)	PUNCT
admet-276	15	17	has	have	AUX
admet-276	15	18	becomes	become	VERB
admet-276	15	19	a	a	DET
admet-276	15	20	standardized	standardized	ADJ
admet-276	15	21	paradigm	paradigm	NOUN
admet-276	15	22	in	in	ADP
admet-276	15	23	drug	drug	NOUN
admet-276	15	24	discovery	discovery	NOUN
admet-276	15	25	and	and	CCONJ
admet-276	15	26	development	development	NOUN
admet-276	15	27	in	in	ADP
admet-276	15	28	terms	term	NOUN
admet-276	15	29	of	of	ADP
admet-276	15	30	in	in	ADP
admet-276	15	31	vitro	vitro	X
admet-276	15	32	screening	screen	VERB
admet-276	15	33	,	,	PUNCT
admet-276	15	34	in	in	ADP
admet-276	15	35	vivo	vivo	ADJ
admet-276	15	36	animal	animal	NOUN
admet-276	15	37	studies	study	NOUN
admet-276	15	38	,	,	PUNCT
admet-276	15	39	lc	lc	PROPN
admet-276	15	40	-	-	PUNCT
admet-276	15	41	ms	ms	PROPN
admet-276	15	42	/	/	SYM
admet-276	15	43	ms	ms	PROPN
admet-276	15	44	based	base	VERB
admet-276	15	45	bioanalysis	bioanalysis	NOUN
admet-276	15	46	as	as	ADV
admet-276	15	47	well	well	ADV
admet-276	15	48	as	as	ADP
admet-276	15	49	regulatory	regulatory	ADJ
admet-276	15	50	considerations	consideration	NOUN
admet-276	15	51	including	include	VERB
admet-276	15	52	ddi	ddi	NOUN
admet-276	15	53	and	and	CCONJ
admet-276	15	54	drug	drug	NOUN
admet-276	15	55	metabolite	metabolite	NOUN
admet-276	15	56	safety	safety	NOUN
admet-276	15	57	testing	testing	NOUN
admet-276	15	58	etc	etc	X
admet-276	15	59	.	.	X
admet-276	16	1	however	however	ADV
admet-276	16	2	,	,	PUNCT
admet-276	16	3	adme	adme	NOUN
admet-276	16	4	testing	testing	NOUN
admet-276	16	5	of	of	ADP
admet-276	16	6	lms	lm	NOUN
admet-276	16	7	lags	lag	VERB
admet-276	16	8	behind	behind	ADP
admet-276	16	9	that	that	PRON
admet-276	16	10	of	of	ADP
admet-276	16	11	sms	sms	PROPN
admet-276	16	12	due	due	ADP
admet-276	16	13	to	to	ADP
admet-276	16	14	the	the	DET
admet-276	16	15	complex	complex	ADJ
admet-276	16	16	nature	nature	NOUN
admet-276	16	17	of	of	ADP
admet-276	16	18	the	the	DET
admet-276	16	19	biological	biological	ADJ
admet-276	16	20	molecules	molecule	NOUN
admet-276	16	21	and	and	CCONJ
admet-276	16	22	also	also	ADV
admet-276	16	23	lack	lack	NOUN
admet-276	16	24	of	of	ADP
admet-276	16	25	appropriate	appropriate	ADJ
admet-276	16	26	tools	tool	NOUN
admet-276	16	27	to	to	PART
admet-276	16	28	study	study	VERB
admet-276	16	29	drug	drug	NOUN
admet-276	16	30	exposure	exposure	NOUN
admet-276	16	31	,	,	PUNCT
admet-276	16	32	biotransformation	biotransformation	NOUN
admet-276	16	33	and	and	CCONJ
admet-276	16	34	target	target	NOUN
admet-276	16	35	engagement	engagement	NOUN
admet-276	16	36	in	in	ADP
admet-276	16	37	the	the	DET
admet-276	16	38	vascular	vascular	ADJ
admet-276	16	39	and	and	CCONJ
admet-276	16	40	tissue	tissue	NOUN
admet-276	16	41	spaces	space	NOUN
admet-276	16	42	[	[	X
admet-276	16	43	2	2	NUM
admet-276	16	44	]	]	PUNCT
admet-276	16	45	.	.	PUNCT
admet-276	17	1	adme	adme	NOUN
admet-276	17	2	of	of	ADP
admet-276	17	3	lms	lm	NOUN
admet-276	17	4	or	or	CCONJ
admet-276	17	5	biologics	biologic	NOUN
admet-276	17	6	are	be	AUX
admet-276	17	7	still	still	ADV
admet-276	17	8	based	base	VERB
admet-276	17	9	on	on	ADP
admet-276	17	10	the	the	DET
admet-276	17	11	lessons	lesson	NOUN
admet-276	17	12	learned	learn	VERB
admet-276	17	13	from	from	ADP
admet-276	17	14	the	the	DET
admet-276	17	15	sms	sms	NOUN
admet-276	17	16	and	and	CCONJ
admet-276	17	17	the	the	DET
admet-276	17	18	tools	tool	NOUN
admet-276	17	19	that	that	PRON
admet-276	17	20	have	have	AUX
admet-276	17	21	applied	apply	VERB
admet-276	17	22	to	to	ADP
admet-276	17	23	sm	sm	PROPN
admet-276	17	24	drugs	drug	NOUN
admet-276	17	25	[	[	X
admet-276	17	26	5	5	NUM
admet-276	17	27	]	]	PUNCT
admet-276	17	28	.	.	PUNCT
admet-276	18	1	in	in	ADP
admet-276	18	2	general	general	ADJ
admet-276	18	3	,	,	PUNCT
admet-276	18	4	there	there	PRON
admet-276	18	5	is	be	VERB
admet-276	18	6	a	a	DET
admet-276	18	7	similar	similar	ADJ
admet-276	18	8	high	high	ADJ
admet-276	18	9	level	level	NOUN
admet-276	18	10	pk	pk	NOUN
admet-276	18	11	/	/	SYM
admet-276	18	12	pd	pd	NOUN
admet-276	18	13	relation	relation	NOUN
admet-276	18	14	concept	concept	NOUN
admet-276	18	15	between	between	ADP
admet-276	18	16	the	the	DET
admet-276	18	17	sms	sms	NOUN
admet-276	18	18	and	and	CCONJ
admet-276	18	19	lms	lm	NOUN
admet-276	18	20	,	,	PUNCT
admet-276	18	21	although	although	SCONJ
admet-276	18	22	they	they	PRON
admet-276	18	23	have	have	VERB
admet-276	18	24	different	different	ADJ
admet-276	18	25	adme	adme	NOUN
admet-276	18	26	mechanisms	mechanism	NOUN
admet-276	18	27	and	and	CCONJ
admet-276	18	28	underlying	underlying	ADJ
admet-276	18	29	admet	admet	NOUN
admet-276	18	30	determinants	determinant	NOUN
admet-276	18	31	at	at	ADP
admet-276	18	32	different	different	ADJ
admet-276	18	33	stages	stage	NOUN
admet-276	18	34	[	[	X
admet-276	18	35	5	5	NUM
admet-276	18	36	]	]	PUNCT
admet-276	18	37	.	.	PUNCT
admet-276	19	1	characterizing	characterize	VERB
admet-276	19	2	the	the	DET
admet-276	19	3	absorption	absorption	NOUN
admet-276	19	4	,	,	PUNCT
admet-276	19	5	distribution	distribution	NOUN
admet-276	19	6	,	,	PUNCT
admet-276	19	7	metabolism	metabolism	NOUN
admet-276	19	8	,	,	PUNCT
admet-276	19	9	and	and	CCONJ
admet-276	19	10	excretion	excretion	NOUN
admet-276	19	11	of	of	ADP
admet-276	19	12	these	these	DET
admet-276	19	13	lm	lm	INTJ
admet-276	19	14	drugs	drug	NOUN
admet-276	19	15	(	(	PUNCT
admet-276	19	16	mabs	mab	NOUN
admet-276	19	17	and	and	CCONJ
admet-276	19	18	adcs	adc	NOUN
admet-276	19	19	)	)	PUNCT
admet-276	19	20	in	in	ADP
admet-276	19	21	preclinical	preclinical	ADJ
admet-276	19	22	animal	animal	NOUN
admet-276	19	23	models	model	NOUN
admet-276	19	24	can	can	AUX
admet-276	19	25	better	well	ADV
admet-276	19	26	predict	predict	VERB
admet-276	19	27	their	their	PRON
admet-276	19	28	efficacy	efficacy	NOUN
admet-276	19	29	and	and	CCONJ
admet-276	19	30	tolerability	tolerability	NOUN
admet-276	19	31	in	in	ADP
admet-276	19	32	clinic	clinic	NOUN
admet-276	19	33	.	.	PUNCT
admet-276	20	1	accordingly	accordingly	ADV
admet-276	20	2	,	,	PUNCT
admet-276	20	3	it	it	PRON
admet-276	20	4	is	be	AUX
admet-276	20	5	necessary	necessary	ADJ
admet-276	20	6	to	to	PART
admet-276	20	7	understand	understand	VERB
admet-276	20	8	general	general	ADJ
admet-276	20	9	characteristics	characteristic	NOUN
admet-276	20	10	and	and	CCONJ
admet-276	20	11	the	the	DET
admet-276	20	12	difference	difference	NOUN
admet-276	20	13	between	between	ADP
admet-276	20	14	sms	sms	PROPN
admet-276	20	15	and	and	CCONJ
admet-276	20	16	lms	lm	NOUN
admet-276	20	17	(	(	PUNCT
admet-276	20	18	e.g.	e.g.	ADV
admet-276	20	19	,	,	PUNCT
admet-276	20	20	antibody	antibody	NOUN
admet-276	20	21	and	and	CCONJ
admet-276	20	22	adc	adc	PROPN
admet-276	20	23	)	)	PUNCT
admet-276	21	1	in	in	ADP
admet-276	21	2	order	order	NOUN
admet-276	21	3	to	to	PART
admet-276	21	4	apply	apply	VERB
admet-276	21	5	relevant	relevant	ADJ
admet-276	21	6	approaches	approach	NOUN
admet-276	21	7	for	for	ADP
admet-276	21	8	adme	adme	NOUN
admet-276	21	9	testing	testing	NOUN
admet-276	21	10	and	and	CCONJ
admet-276	21	11	safety	safety	NOUN
admet-276	21	12	evaluation	evaluation	NOUN
admet-276	21	13	of	of	ADP
admet-276	21	14	lms	lm	NOUN
admet-276	21	15	as	as	SCONJ
admet-276	21	16	reviewed	review	VERB
admet-276	21	17	in	in	ADP
admet-276	21	18	a	a	DET
admet-276	21	19	number	number	NOUN
admet-276	21	20	of	of	ADP
admet-276	21	21	recent	recent	ADJ
admet-276	21	22	publications	publication	NOUN
admet-276	21	23	[	[	X
admet-276	21	24	2,3,5,8	2,3,5,8	NUM
admet-276	21	25	-	-	SYM
admet-276	21	26	11	11	NUM
admet-276	21	27	]	]	PUNCT
admet-276	21	28	.	.	PUNCT
admet-276	22	1	in	in	ADP
admet-276	22	2	a	a	DET
admet-276	22	3	previous	previous	ADJ
admet-276	22	4	review	review	NOUN
admet-276	22	5	,	,	PUNCT
admet-276	22	6	what	what	PRON
admet-276	22	7	adme	adme	NOUN
admet-276	22	8	tests	test	NOUN
admet-276	22	9	should	should	AUX
admet-276	22	10	be	be	AUX
admet-276	22	11	conducted	conduct	VERB
admet-276	22	12	for	for	ADP
admet-276	22	13	small	small	ADJ
admet-276	22	14	molecule	molecule	NOUN
admet-276	22	15	drugs	drug	NOUN
admet-276	22	16	for	for	ADP
admet-276	22	17	preclinical	preclinical	ADJ
admet-276	22	18	studies	study	NOUN
admet-276	22	19	was	be	AUX
admet-276	22	20	highlighted	highlight	VERB
admet-276	22	21	[	[	X
admet-276	22	22	12	12	NUM
admet-276	22	23	]	]	PUNCT
admet-276	22	24	.	.	PUNCT
admet-276	23	1	this	this	DET
admet-276	23	2	review	review	NOUN
admet-276	23	3	will	will	AUX
admet-276	23	4	provide	provide	VERB
admet-276	23	5	an	an	DET
admet-276	23	6	overall	overall	ADJ
admet-276	23	7	comparison	comparison	NOUN
admet-276	23	8	between	between	ADP
admet-276	23	9	sm	sm	PROPN
admet-276	23	10	and	and	CCONJ
admet-276	23	11	lm	lm	NOUN
admet-276	23	12	properties	property	NOUN
admet-276	23	13	with	with	ADP
admet-276	23	14	a	a	DET
admet-276	23	15	particular	particular	ADJ
admet-276	23	16	focus	focus	NOUN
admet-276	23	17	on	on	ADP
admet-276	23	18	adc	adc	PROPN
admet-276	23	19	’s	’s	PART
admet-276	23	20	characteristics	characteristic	NOUN
admet-276	23	21	to	to	PART
admet-276	23	22	gain	gain	VERB
admet-276	23	23	a	a	DET
admet-276	23	24	better	well	ADJ
admet-276	23	25	understanding	understanding	NOUN
admet-276	23	26	of	of	ADP
admet-276	23	27	in	in	ADP
admet-276	23	28	vitro	vitro	X
admet-276	23	29	and	and	CCONJ
admet-276	23	30	in	in	ADP
admet-276	23	31	vivo	vivo	NOUN
admet-276	23	32	adme	adme	NOUN
admet-276	23	33	testing	testing	NOUN
admet-276	23	34	as	as	ADV
admet-276	23	35	well	well	ADV
admet-276	23	36	as	as	ADP
admet-276	23	37	toxicity	toxicity	NOUN
admet-276	23	38	evaluations	evaluation	NOUN
admet-276	23	39	.	.	PUNCT
admet-276	24	1	the	the	DET
admet-276	24	2	in	in	ADP
admet-276	24	3	-	-	PUNCT
admet-276	24	4	depth	depth	NOUN
admet-276	24	5	information	information	NOUN
admet-276	24	6	of	of	ADP
admet-276	24	7	adme	adme	NOUN
admet-276	24	8	will	will	AUX
admet-276	24	9	also	also	ADV
admet-276	24	10	be	be	AUX
admet-276	24	11	valuable	valuable	ADJ
admet-276	24	12	for	for	ADP
admet-276	24	13	the	the	DET
admet-276	24	14	designing	designing	NOUN
admet-276	24	15	of	of	ADP
admet-276	24	16	novel	novel	ADJ
admet-276	24	17	mab	mab	NOUN
admet-276	24	18	constructs	construct	NOUN
admet-276	24	19	and	and	CCONJ
admet-276	24	20	next	next	ADJ
admet-276	24	21	generation	generation	NOUN
admet-276	24	22	of	of	ADP
admet-276	24	23	adcs	adcs	ADV
admet-276	24	24	with	with	ADP
admet-276	24	25	desirable	desirable	ADJ
admet-276	24	26	pk	pk	NOUN
admet-276	24	27	profile	profile	NOUN
admet-276	24	28	and	and	CCONJ
admet-276	24	29	safety	safety	NOUN
admet-276	24	30	window	window	NOUN
admet-276	24	31	.	.	PUNCT
admet-276	25	1	2	2	X
admet-276	25	2	.	.	X
admet-276	25	3	general	general	ADJ
admet-276	25	4	differences	difference	NOUN
admet-276	25	5	between	between	ADP
admet-276	25	6	sms	sms	PROPN
admet-276	25	7	and	and	CCONJ
admet-276	25	8	lms	lm	NOUN
admet-276	25	9	(	(	PUNCT
admet-276	25	10	mab	mab	NOUN
admet-276	25	11	and	and	CCONJ
admet-276	25	12	adc	adc	PROPN
admet-276	25	13	)	)	PUNCT
admet-276	25	14	in	in	ADP
admet-276	25	15	adme	adme	NOUN
admet-276	25	16	testing	testing	NOUN
admet-276	25	17	table	table	NOUN
admet-276	25	18	1	1	NUM
admet-276	25	19	summarizes	summarize	NOUN
admet-276	25	20	general	general	ADJ
admet-276	25	21	differences	difference	NOUN
admet-276	25	22	between	between	ADP
admet-276	25	23	sms	sms	PROPN
admet-276	25	24	and	and	CCONJ
admet-276	25	25	lms	lm	NOUN
admet-276	25	26	with	with	ADP
admet-276	25	27	an	an	DET
admet-276	25	28	overall	overall	ADJ
admet-276	25	29	comparison	comparison	NOUN
admet-276	25	30	of	of	ADP
admet-276	25	31	mab	mab	PROPN
admet-276	25	32	and	and	CCONJ
admet-276	25	33	adc	adc	PROPN
admet-276	25	34	.	.	PUNCT
admet-276	26	1	as	as	SCONJ
admet-276	26	2	highlighted	highlight	VERB
admet-276	26	3	in	in	ADP
admet-276	26	4	table	table	NOUN
admet-276	26	5	1	1	NUM
admet-276	26	6	,	,	PUNCT
admet-276	26	7	due	due	ADP
admet-276	26	8	to	to	ADP
admet-276	26	9	the	the	DET
admet-276	26	10	nature	nature	NOUN
admet-276	26	11	of	of	ADP
admet-276	26	12	various	various	ADJ
admet-276	26	13	characteristics	characteristic	NOUN
admet-276	26	14	between	between	ADP
admet-276	26	15	sms	sms	PROPN
admet-276	26	16	and	and	CCONJ
admet-276	26	17	lms	lm	NOUN
admet-276	26	18	,	,	PUNCT
admet-276	26	19	the	the	DET
admet-276	26	20	focus	focus	NOUN
admet-276	26	21	on	on	ADP
admet-276	26	22	adme	adme	NOUN
admet-276	26	23	studies	study	NOUN
admet-276	26	24	of	of	ADP
admet-276	26	25	lms	lm	NOUN
admet-276	26	26	is	be	AUX
admet-276	26	27	thus	thus	ADV
admet-276	26	28	different	different	ADJ
admet-276	26	29	from	from	ADP
admet-276	26	30	sms	sms	PROPN
admet-276	26	31	in	in	ADP
admet-276	26	32	particular	particular	ADJ
admet-276	26	33	for	for	ADP
admet-276	26	34	drug	drug	NOUN
admet-276	26	35	metabolite	metabolite	NOUN
admet-276	26	36	safety	safety	NOUN
admet-276	26	37	testing	testing	NOUN
admet-276	26	38	and	and	CCONJ
admet-276	26	39	ddi	ddi	PROPN
admet-276	26	40	evaluations	evaluation	NOUN
admet-276	26	41	.	.	PUNCT
admet-276	27	1	in	in	ADP
admet-276	27	2	these	these	DET
admet-276	27	3	aspects	aspect	NOUN
admet-276	27	4	,	,	PUNCT
admet-276	27	5	in	in	ADP
admet-276	27	6	vitro	vitro	X
admet-276	27	7	models	model	NOUN
admet-276	27	8	and	and	CCONJ
admet-276	27	9	in	in	ADP
admet-276	27	10	vivo	vivo	ADJ
admet-276	27	11	studies	study	NOUN
admet-276	27	12	and	and	CCONJ
admet-276	27	13	related	related	ADJ
admet-276	27	14	bioanalysis	bioanalysis	NOUN
admet-276	27	15	including	include	VERB
admet-276	27	16	transporter	transporter	NOUN
admet-276	27	17	studies	study	NOUN
admet-276	27	18	and	and	CCONJ
admet-276	27	19	safety	safety	NOUN
admet-276	27	20	evaluation	evaluation	NOUN
admet-276	27	21	and	and	CCONJ
admet-276	27	22	high	high	ADJ
admet-276	27	23	-	-	PUNCT
admet-276	27	24	throughput	throughput	NOUN
admet-276	27	25	screening	screening	NOUN
admet-276	27	26	approaches	approach	NOUN
admet-276	27	27	for	for	ADP
admet-276	27	28	sms	sm	NOUN
admet-276	27	29	have	have	AUX
admet-276	27	30	well	well	ADV
admet-276	27	31	been	be	AUX
admet-276	27	32	established	establish	VERB
admet-276	27	33	across	across	ADP
admet-276	27	34	pharmaceutical	pharmaceutical	NOUN
admet-276	27	35	industry	industry	NOUN
admet-276	27	36	[	[	X
admet-276	27	37	12	12	NUM
admet-276	27	38	-	-	SYM
admet-276	27	39	20	20	NUM
admet-276	27	40	]	]	PUNCT
admet-276	27	41	.	.	PUNCT
admet-276	28	1	typical	typical	ADJ
admet-276	28	2	in	in	ADP
admet-276	28	3	vitro	vitro	X
admet-276	28	4	adme	adme	NOUN
admet-276	28	5	tests	test	NOUN
admet-276	28	6	for	for	ADP
admet-276	28	7	sms	sm	NOUN
admet-276	28	8	are	be	AUX
admet-276	28	9	metabolic	metabolic	ADJ
admet-276	28	10	stability	stability	NOUN
admet-276	28	11	by	by	ADP
admet-276	28	12	liver	liver	NOUN
admet-276	28	13	microsmoes	microsmoe	NOUN
admet-276	28	14	or	or	CCONJ
admet-276	28	15	/	/	SYM
admet-276	28	16	and	and	CCONJ
admet-276	28	17	hepatocytes	hepatocyte	NOUN
admet-276	28	18	and	and	CCONJ
admet-276	28	19	passive	passive	ADJ
admet-276	28	20	permeability	permeability	NOUN
admet-276	28	21	on	on	ADP
admet-276	28	22	cell	cell	NOUN
admet-276	28	23	-	-	PUNCT
admet-276	28	24	line	line	NOUN
admet-276	28	25	models	model	NOUN
admet-276	28	26	based	base	VERB
admet-276	28	27	on	on	ADP
admet-276	28	28	caco-2	caco-2	NUM
admet-276	28	29	or	or	CCONJ
admet-276	28	30	mdck	mdck	ADJ
admet-276	28	31	assays	assay	NOUN
admet-276	28	32	,	,	PUNCT
admet-276	28	33	which	which	PRON
admet-276	28	34	are	be	AUX
admet-276	28	35	commonly	commonly	ADV
admet-276	28	36	utilized	utilize	VERB
admet-276	28	37	to	to	PART
admet-276	28	38	predict	predict	VERB
admet-276	28	39	in	in	ADP
admet-276	28	40	vivo	vivo	ADJ
admet-276	28	41	clearance	clearance	NOUN
admet-276	28	42	and	and	CCONJ
admet-276	28	43	absorption	absorption	NOUN
admet-276	28	44	or	or	CCONJ
admet-276	28	45	bioavailability	bioavailability	NOUN
admet-276	28	46	as	as	ADV
admet-276	28	47	well	well	ADV
admet-276	28	48	as	as	ADP
admet-276	28	49	potential	potential	ADJ
admet-276	28	50	drug	drug	NOUN
admet-276	28	51	-	-	PUNCT
admet-276	28	52	drug	drug	NOUN
admet-276	28	53	interaction	interaction	NOUN
admet-276	28	54	(	(	PUNCT
admet-276	28	55	ddi	ddi	PROPN
admet-276	28	56	)	)	PUNCT
admet-276	28	57	evaluations	evaluation	NOUN
admet-276	28	58	and	and	CCONJ
admet-276	28	59	metabolism	metabolism	NOUN
admet-276	28	60	pathway	pathway	NOUN
admet-276	28	61	studies	study	NOUN
admet-276	28	62	.	.	PUNCT
admet-276	29	1	in	in	ADP
admet-276	29	2	particular	particular	ADJ
admet-276	29	3	,	,	PUNCT
admet-276	29	4	a	a	DET
admet-276	29	5	common	common	ADJ
admet-276	29	6	consensus	consensus	NOUN
admet-276	29	7	has	have	AUX
admet-276	29	8	been	be	AUX
admet-276	29	9	reached	reach	VERB
admet-276	29	10	on	on	ADP
admet-276	29	11	drug	drug	NOUN
admet-276	29	12	metabolite	metabolite	NOUN
admet-276	29	13	testing	testing	NOUN
admet-276	29	14	across	across	ADP
admet-276	29	15	various	various	ADJ
admet-276	29	16	species	specie	NOUN
admet-276	29	17	from	from	ADP
admet-276	29	18	in	in	ADP
admet-276	29	19	vitro	vitro	X
admet-276	29	20	models	model	NOUN
admet-276	29	21	to	to	ADP
admet-276	29	22	in	in	ADP
admet-276	29	23	vivo	vivo	ADJ
admet-276	29	24	studies	study	NOUN
admet-276	29	25	following	follow	VERB
admet-276	29	26	regulatory	regulatory	ADJ
admet-276	29	27	guidance	guidance	NOUN
admet-276	29	28	,	,	PUNCT
admet-276	29	29	which	which	PRON
admet-276	29	30	clearly	clearly	ADV
admet-276	29	31	suggests	suggest	VERB
admet-276	29	32	critical	critical	ADJ
admet-276	29	33	criteria	criterion	NOUN
admet-276	29	34	for	for	ADP
admet-276	29	35	decision	decision	NOUN
admet-276	29	36	-	-	PUNCT
admet-276	29	37	tree	tree	NOUN
admet-276	29	38	making	making	NOUN
admet-276	29	39	in	in	ADP
admet-276	29	40	assessing	assess	VERB
admet-276	29	41	key	key	ADJ
admet-276	29	42	drug	drug	NOUN
admet-276	29	43	metabolite	metabolite	NOUN
admet-276	29	44	safety	safety	NOUN
admet-276	29	45	in	in	ADP
admet-276	29	46	human	human	ADJ
admet-276	29	47	[	[	X
admet-276	29	48	21,22	21,22	NOUN
admet-276	29	49	]	]	X
admet-276	29	50	.	.	PUNCT
admet-276	30	1	similarly	similarly	ADV
admet-276	30	2	,	,	PUNCT
admet-276	30	3	cytochrome	cytochrome	ADJ
admet-276	30	4	p450	p450	PROPN
admet-276	30	5	(	(	PUNCT
admet-276	30	6	cyp	cyp	ADJ
admet-276	30	7	)	)	PUNCT
admet-276	30	8	enzymes	enzyme	NOUN
admet-276	30	9	based	base	VERB
admet-276	30	10	ddi	ddi	PROPN
admet-276	30	11	as	as	ADV
admet-276	30	12	well	well	ADV
admet-276	30	13	as	as	ADP
admet-276	30	14	transporter	transporter	NOUN
admet-276	30	15	-	-	PUNCT
admet-276	30	16	mediated	mediate	VERB
admet-276	30	17	ddi	ddi	NOUN
admet-276	30	18	of	of	ADP
admet-276	30	19	sms	sms	PROPN
admet-276	30	20	are	be	AUX
admet-276	30	21	also	also	ADV
admet-276	30	22	defined	define	VERB
admet-276	30	23	and	and	CCONJ
admet-276	30	24	guided	guide	VERB
admet-276	30	25	on	on	ADP
admet-276	30	26	the	the	DET
admet-276	30	27	basis	basis	NOUN
admet-276	30	28	of	of	ADP
admet-276	30	29	many	many	ADJ
admet-276	30	30	years	year	NOUN
admet-276	30	31	industrious	industrious	ADJ
admet-276	30	32	practice	practice	NOUN
admet-276	30	33	of	of	ADP
admet-276	30	34	drug	drug	NOUN
admet-276	30	35	discovery	discovery	NOUN
admet-276	30	36	and	and	CCONJ
admet-276	30	37	development	development	NOUN
admet-276	31	1	[	[	X
admet-276	31	2	23	23	NUM
admet-276	31	3	]	]	PUNCT
admet-276	31	4	.	.	PUNCT
admet-276	32	1	on	on	ADP
admet-276	32	2	the	the	DET
admet-276	32	3	contrary	contrary	NOUN
admet-276	32	4	,	,	PUNCT
admet-276	32	5	adme	adme	NOUN
admet-276	32	6	testing	testing	NOUN
admet-276	32	7	of	of	ADP
admet-276	32	8	biologics	biologic	NOUN
admet-276	32	9	(	(	PUNCT
admet-276	32	10	mabs	mab	NOUN
admet-276	32	11	and	and	CCONJ
admet-276	32	12	adcs	adc	NOUN
admet-276	32	13	)	)	PUNCT
admet-276	32	14	can	can	AUX
admet-276	32	15	be	be	AUX
admet-276	32	16	rather	rather	ADV
admet-276	32	17	diverse	diverse	ADJ
admet-276	32	18	as	as	SCONJ
admet-276	32	19	highlighted	highlight	VERB
admet-276	32	20	in	in	ADP
admet-276	32	21	table	table	NOUN
admet-276	32	22	1	1	NUM
admet-276	32	23	and	and	CCONJ
admet-276	32	24	figure	figure	VERB
admet-276	32	25	1	1	NUM
admet-276	32	26	.	.	PUNCT
admet-276	32	27	biodistribution	biodistribution	NOUN
admet-276	32	28	of	of	ADP
admet-276	32	29	mabs	mab	NOUN
admet-276	32	30	and	and	CCONJ
admet-276	32	31	adcs	adc	NOUN
admet-276	32	32	are	be	AUX
admet-276	32	33	usually	usually	ADV
admet-276	32	34	similar	similar	ADJ
admet-276	32	35	[	[	X
admet-276	32	36	24	24	NUM
admet-276	32	37	]	]	PUNCT
admet-276	32	38	,	,	PUNCT
admet-276	32	39	but	but	CCONJ
admet-276	32	40	both	both	PRON
admet-276	32	41	have	have	VERB
admet-276	32	42	much	much	ADV
admet-276	32	43	lower	low	ADJ
admet-276	32	44	vd	vd	NOUN
admet-276	32	45	than	than	ADP
admet-276	32	46	that	that	PRON
admet-276	32	47	of	of	ADP
admet-276	32	48	a	a	DET
admet-276	32	49	typical	typical	ADJ
admet-276	32	50	sm	sm	NOUN
admet-276	32	51	drug	drug	NOUN
admet-276	32	52	as	as	ADP
admet-276	32	53	the	the	DET
admet-276	32	54	structure	structure	NOUN
admet-276	32	55	of	of	ADP
admet-276	32	56	mabs	mab	NOUN
admet-276	32	57	or	or	CCONJ
admet-276	32	58	adcs	adcs	NOUN
admet-276	32	59	is	be	AUX
admet-276	32	60	dominated	dominate	VERB
admet-276	32	61	by	by	ADP
admet-276	32	62	the	the	DET
admet-276	32	63	antibody	antibody	NOUN
admet-276	32	64	backbone	backbone	NOUN
admet-276	32	65	with	with	ADP
admet-276	32	66	initial	initial	ADJ
admet-276	32	67	distribution	distribution	NOUN
admet-276	32	68	limited	limit	VERB
admet-276	32	69	to	to	ADP
admet-276	32	70	the	the	DET
admet-276	32	71	vascular	vascular	ADJ
admet-276	32	72	space	space	NOUN
admet-276	32	73	or	or	CCONJ
admet-276	32	74	plasma	plasma	NOUN
admet-276	32	75	,	,	PUNCT
admet-276	32	76	not	not	PART
admet-276	32	77	organ	organ	NOUN
admet-276	32	78	tissues	tissue	NOUN
admet-276	32	79	.	.	PUNCT
admet-276	33	1	while	while	SCONJ
admet-276	33	2	the	the	DET
admet-276	33	3	drug	drug	NOUN
admet-276	33	4	metabolism	metabolism	NOUN
admet-276	33	5	of	of	ADP
admet-276	33	6	mabs	mab	NOUN
admet-276	33	7	is	be	AUX
admet-276	33	8	more	more	ADV
admet-276	33	9	complex	complex	ADJ
admet-276	33	10	due	due	ADP
admet-276	33	11	to	to	ADP
admet-276	33	12	receptor	receptor	NOUN
admet-276	33	13	binding	bind	VERB
admet-276	33	14	target	target	NOUN
admet-276	33	15	-	-	PUNCT
admet-276	33	16	mediated	mediate	VERB
admet-276	33	17	drug	drug	NOUN
admet-276	33	18	disposition	disposition	NOUN
admet-276	33	19	(	(	PUNCT
admet-276	33	20	tmdd	tmdd	PROPN
admet-276	33	21	)	)	PUNCT
admet-276	33	22	,	,	PUNCT
admet-276	33	23	fcrn	fcrn	NOUN
admet-276	33	24	binding	binding	ADJ
admet-276	33	25	and	and	CCONJ
admet-276	33	26	lysosomal	lysosomal	ADJ
admet-276	33	27	degradation	degradation	NOUN
admet-276	33	28	,	,	PUNCT
admet-276	33	29	tissue	tissue	NOUN
admet-276	33	30	protease	protease	NOUN
admet-276	33	31	,	,	PUNCT
admet-276	33	32	immune	immune	ADJ
admet-276	33	33	response	response	NOUN
admet-276	33	34	antibody	antibody	NOUN
admet-276	33	35	mediated	mediate	VERB
admet-276	33	36	metabolism	metabolism	NOUN
admet-276	33	37	etc	etc	X
admet-276	33	38	in	in	ADP
admet-276	33	39	addition	addition	NOUN
admet-276	33	40	to	to	ADP
admet-276	33	41	admet	admet	PROPN
admet-276	33	42	&	&	CCONJ
admet-276	33	43	dmpk	dmpk	PROPN
admet-276	33	44	4(1	4(1	NOUN
admet-276	33	45	)	)	PUNCT
admet-276	33	46	(	(	PUNCT
admet-276	33	47	2016	2016	NUM
admet-276	33	48	)	)	PUNCT
admet-276	33	49	1	1	NUM
admet-276	33	50	-	-	SYM
admet-276	33	51	22	22	NUM
admet-276	33	52	adme	adme	NOUN
admet-276	33	53	testing	testing	NOUN
admet-276	33	54	of	of	ADP
admet-276	33	55	large	large	ADJ
admet-276	33	56	biologics	biologic	NOUN
admet-276	33	57	doi	doi	NOUN
admet-276	33	58	:	:	PUNCT
admet-276	33	59	10.5599	10.5599	NUM
admet-276	33	60	/	/	SYM
admet-276	33	61	admet.4.1.276	admet.4.1.276	NUM
admet-276	33	62	3	3	NUM
admet-276	33	63	other	other	ADJ
admet-276	33	64	metabolic	metabolic	NOUN
admet-276	33	65	or	or	CCONJ
admet-276	33	66	metabolic	metabolic	NOUN
admet-276	33	67	-	-	PUNCT
admet-276	33	68	like	like	ADJ
admet-276	33	69	biotransformation	biotransformation	NOUN
admet-276	33	70	such	such	ADJ
admet-276	33	71	modifications	modification	NOUN
admet-276	33	72	as	as	ADP
admet-276	33	73	deamidation	deamidation	NOUN
admet-276	33	74	,	,	PUNCT
admet-276	33	75	oxidation	oxidation	NOUN
admet-276	33	76	,	,	PUNCT
admet-276	33	77	isomerization	isomerization	NOUN
admet-276	33	78	,	,	PUNCT
admet-276	33	79	disulfide	disulfide	NOUN
admet-276	33	80	bond	bond	NOUN
admet-276	33	81	reduction	reduction	NOUN
admet-276	33	82	or	or	CCONJ
admet-276	33	83	shuffling	shuffle	VERB
admet-276	33	84	and	and	CCONJ
admet-276	33	85	proteolytic	proteolytic	ADJ
admet-276	33	86	or	or	CCONJ
admet-276	33	87	glycolytic	glycolytic	ADJ
admet-276	33	88	hydrolysis	hydrolysis	NOUN
admet-276	33	89	(	(	PUNCT
admet-276	33	90	ref	ref	NOUN
admet-276	33	91	.	.	PUNCT
admet-276	34	1	therein	therein	ADV
admet-276	34	2	)	)	PUNCT
admet-276	35	1	[	[	X
admet-276	35	2	11	11	NUM
admet-276	35	3	]	]	PUNCT
admet-276	35	4	.	.	PUNCT
admet-276	36	1	the	the	DET
admet-276	36	2	metabolism	metabolism	NOUN
admet-276	36	3	/catabolism	/catabolism	PUNCT
admet-276	36	4	of	of	ADP
admet-276	36	5	adcs	adcs	PROPN
admet-276	36	6	can	can	AUX
admet-276	36	7	be	be	AUX
admet-276	36	8	more	more	ADV
admet-276	36	9	complicated	complicated	ADJ
admet-276	36	10	than	than	ADP
admet-276	36	11	mabs	mab	NOUN
admet-276	36	12	due	due	ADP
admet-276	36	13	to	to	ADP
admet-276	36	14	a	a	DET
admet-276	36	15	cytotoxic	cytotoxic	ADJ
admet-276	36	16	drug	drug	NOUN
admet-276	36	17	linked	link	VERB
admet-276	36	18	to	to	ADP
admet-276	36	19	the	the	DET
admet-276	36	20	antibody	antibody	NOUN
admet-276	36	21	via	via	ADP
admet-276	36	22	a	a	DET
admet-276	36	23	linker	linker	NOUN
admet-276	36	24	.	.	PUNCT
admet-276	37	1	typically	typically	ADV
admet-276	37	2	,	,	PUNCT
admet-276	37	3	the	the	DET
admet-276	37	4	circulating	circulate	VERB
admet-276	37	5	unconjugated	unconjugated	ADJ
admet-276	37	6	drug	drug	NOUN
admet-276	37	7	after	after	ADP
admet-276	37	8	the	the	DET
admet-276	37	9	adc	adc	PROPN
admet-276	37	10	administration	administration	NOUN
admet-276	37	11	has	have	VERB
admet-276	37	12	metabolic	metabolic	NOUN
admet-276	37	13	properties	property	NOUN
admet-276	37	14	of	of	ADP
admet-276	37	15	small	small	ADJ
admet-276	37	16	-	-	PUNCT
admet-276	37	17	molecule	molecule	NOUN
admet-276	37	18	compounds	compound	NOUN
admet-276	37	19	.	.	PUNCT
admet-276	38	1	hence	hence	ADV
admet-276	38	2	,	,	PUNCT
admet-276	38	3	drug	drug	NOUN
admet-276	38	4	metabolite	metabolite	NOUN
admet-276	38	5	and	and	CCONJ
admet-276	38	6	ddi	ddi	PROPN
admet-276	38	7	should	should	AUX
admet-276	38	8	be	be	AUX
admet-276	38	9	concerned	concern	VERB
admet-276	38	10	for	for	ADP
admet-276	38	11	adc	adc	PROPN
admet-276	38	12	drugs	drug	NOUN
admet-276	38	13	,	,	PUNCT
admet-276	38	14	but	but	CCONJ
admet-276	38	15	maybe	maybe	ADV
admet-276	38	16	not	not	PART
admet-276	38	17	for	for	ADP
admet-276	38	18	mabs	mab	NOUN
admet-276	38	19	wherein	wherein	SCONJ
admet-276	38	20	the	the	DET
admet-276	38	21	ddi	ddi	PROPN
admet-276	38	22	risk	risk	NOUN
admet-276	38	23	is	be	AUX
admet-276	38	24	presumably	presumably	ADV
admet-276	38	25	low	low	ADJ
admet-276	38	26	or	or	CCONJ
admet-276	38	27	not	not	PART
admet-276	38	28	as	as	ADV
admet-276	38	29	prominent	prominent	ADJ
admet-276	38	30	as	as	ADP
admet-276	38	31	small	small	ADJ
admet-276	38	32	molecules	molecule	NOUN
admet-276	38	33	.	.	PUNCT
admet-276	39	1	once	once	ADV
admet-276	39	2	small	small	ADJ
admet-276	39	3	-	-	PUNCT
admet-276	39	4	molecule	molecule	NOUN
admet-276	39	5	drugs	drug	NOUN
admet-276	39	6	released	release	VERB
admet-276	39	7	from	from	ADP
admet-276	39	8	the	the	DET
admet-276	39	9	adcs	adcs	ADJ
admet-276	39	10	,	,	PUNCT
admet-276	39	11	they	they	PRON
admet-276	39	12	may	may	AUX
admet-276	39	13	be	be	AUX
admet-276	39	14	metabolized	metabolize	VERB
admet-276	39	15	by	by	ADP
admet-276	39	16	cyp	cyp	ADJ
admet-276	39	17	enzymes	enzyme	NOUN
admet-276	39	18	and	and	CCONJ
admet-276	39	19	thus	thus	ADV
admet-276	39	20	subject	subject	ADJ
admet-276	39	21	to	to	ADP
admet-276	39	22	potential	potential	ADJ
admet-276	39	23	ddi	ddi	NOUN
admet-276	39	24	from	from	ADP
admet-276	39	25	cyp	cyp	ADJ
admet-276	39	26	enzyme	enzyme	NOUN
admet-276	39	27	inhibitors	inhibitor	NOUN
admet-276	39	28	or	or	CCONJ
admet-276	39	29	inducers	inducer	NOUN
admet-276	39	30	due	due	ADJ
admet-276	39	31	to	to	ADP
admet-276	39	32	payload	payload	VERB
admet-276	39	33	/	/	SYM
admet-276	39	34	small	small	ADJ
admet-276	39	35	molecule	molecule	NOUN
admet-276	39	36	component	component	NOUN
admet-276	39	37	[	[	X
admet-276	39	38	9	9	NUM
admet-276	39	39	]	]	PUNCT
admet-276	39	40	.	.	PUNCT
admet-276	40	1	furthermore	furthermore	ADV
admet-276	40	2	,	,	PUNCT
admet-276	40	3	one	one	NUM
admet-276	40	4	or	or	CCONJ
admet-276	40	5	more	more	ADV
admet-276	40	6	active	active	ADJ
admet-276	40	7	small	small	ADJ
admet-276	40	8	-	-	PUNCT
admet-276	40	9	molecule	molecule	NOUN
admet-276	40	10	drugs	drug	NOUN
admet-276	40	11	may	may	AUX
admet-276	40	12	be	be	AUX
admet-276	40	13	released	release	VERB
admet-276	40	14	from	from	ADP
admet-276	40	15	an	an	DET
admet-276	40	16	adc	adc	NOUN
admet-276	40	17	in	in	ADP
admet-276	40	18	vivo	vivo	NOUN
admet-276	40	19	by	by	ADP
admet-276	40	20	additional	additional	ADJ
admet-276	40	21	catabolism	catabolism	NOUN
admet-276	40	22	mechanism	mechanism	NOUN
admet-276	40	23	.	.	PUNCT
admet-276	41	1	accordingly	accordingly	ADV
admet-276	41	2	,	,	PUNCT
admet-276	41	3	both	both	PRON
admet-276	41	4	unconjugated	unconjugated	ADJ
admet-276	41	5	smallmolecule	smallmolecule	NOUN
admet-276	41	6	drug	drug	NOUN
admet-276	41	7	and	and	CCONJ
admet-276	41	8	released	release	VERB
admet-276	41	9	catabolites	catabolite	NOUN
admet-276	41	10	small	small	ADJ
admet-276	41	11	molecules	molecule	NOUN
admet-276	41	12	may	may	AUX
admet-276	41	13	be	be	AUX
admet-276	41	14	considered	consider	VERB
admet-276	41	15	for	for	ADP
admet-276	41	16	metabolite	metabolite	NOUN
admet-276	41	17	safety	safety	NOUN
admet-276	41	18	and	and	CCONJ
admet-276	41	19	ddi	ddi	VERB
admet-276	41	20	potential	potential	ADJ
admet-276	41	21	evaluations	evaluation	NOUN
admet-276	41	22	for	for	ADP
admet-276	41	23	adcs	adcs	ADJ
admet-276	41	24	.	.	PUNCT
admet-276	42	1	this	this	PRON
admet-276	42	2	is	be	AUX
admet-276	42	3	considered	consider	VERB
admet-276	42	4	to	to	PART
admet-276	42	5	be	be	AUX
admet-276	42	6	a	a	DET
admet-276	42	7	major	major	ADJ
admet-276	42	8	differentiation	differentiation	NOUN
admet-276	42	9	of	of	ADP
admet-276	42	10	adcs	adcs	NOUN
admet-276	42	11	from	from	ADP
admet-276	42	12	mabs	mab	NOUN
admet-276	42	13	regarding	regard	VERB
admet-276	42	14	adme	adme	NOUN
admet-276	42	15	testing	testing	NOUN
admet-276	42	16	as	as	ADP
admet-276	42	17	the	the	DET
admet-276	42	18	degraded	degraded	ADJ
admet-276	42	19	small	small	ADJ
admet-276	42	20	molecules	molecule	NOUN
admet-276	42	21	of	of	ADP
admet-276	42	22	mabs	mab	NOUN
admet-276	42	23	are	be	AUX
admet-276	42	24	often	often	ADV
admet-276	42	25	amino	amino	ADJ
admet-276	42	26	acids	acid	NOUN
admet-276	42	27	,	,	PUNCT
admet-276	42	28	small	small	ADJ
admet-276	42	29	peptides	peptide	NOUN
admet-276	42	30	or	or	CCONJ
admet-276	42	31	small	small	ADJ
admet-276	42	32	carbohydrates	carbohydrate	NOUN
admet-276	42	33	that	that	PRON
admet-276	42	34	are	be	AUX
admet-276	42	35	readily	readily	ADV
admet-276	42	36	eliminated	eliminate	VERB
admet-276	42	37	by	by	ADP
admet-276	42	38	renal	renal	ADJ
admet-276	42	39	excretion	excretion	NOUN
admet-276	42	40	or	or	CCONJ
admet-276	42	41	return	return	VERB
admet-276	42	42	to	to	ADP
admet-276	42	43	the	the	DET
admet-276	42	44	nutrient	nutrient	ADJ
admet-276	42	45	pool	pool	NOUN
admet-276	42	46	without	without	ADP
admet-276	42	47	biological	biological	ADJ
admet-276	42	48	effects	effect	NOUN
admet-276	42	49	or	or	CCONJ
admet-276	42	50	safety	safety	NOUN
admet-276	42	51	consideration	consideration	NOUN
admet-276	43	1	[	[	X
admet-276	43	2	2	2	NUM
admet-276	43	3	]	]	PUNCT
admet-276	43	4	.	.	PUNCT
admet-276	44	1	however	however	ADV
admet-276	44	2	,	,	PUNCT
admet-276	44	3	it	it	PRON
admet-276	44	4	should	should	AUX
admet-276	44	5	be	be	AUX
admet-276	44	6	noted	note	VERB
admet-276	44	7	that	that	SCONJ
admet-276	44	8	examples	example	NOUN
admet-276	44	9	of	of	ADP
admet-276	44	10	therapeutic	therapeutic	ADJ
admet-276	44	11	protein	protein	NOUN
admet-276	44	12	(	(	PUNCT
admet-276	44	13	tp	tp	NOUN
admet-276	44	14	)	)	PUNCT
admet-276	44	15	and	and	CCONJ
admet-276	44	16	small	small	ADJ
admet-276	44	17	-	-	PUNCT
admet-276	44	18	molecule	molecule	NOUN
admet-276	44	19	drug	drug	NOUN
admet-276	44	20	(	(	PUNCT
admet-276	44	21	d	d	NOUN
admet-276	44	22	)	)	PUNCT
admet-276	44	23	interactions	interaction	NOUN
admet-276	44	24	in	in	ADP
admet-276	44	25	clinical	clinical	ADJ
admet-276	44	26	studies	study	NOUN
admet-276	44	27	were	be	AUX
admet-276	44	28	observed	observe	VERB
admet-276	44	29	although	although	SCONJ
admet-276	44	30	the	the	DET
admet-276	44	31	changes	change	NOUN
admet-276	44	32	in	in	ADP
admet-276	44	33	exposures	exposure	NOUN
admet-276	44	34	(	(	PUNCT
admet-276	44	35	auc	auc	NOUN
admet-276	44	36	,	,	PUNCT
admet-276	44	37	cmax	cmax	NOUN
admet-276	44	38	)	)	PUNCT
admet-276	44	39	have	have	AUX
admet-276	44	40	not	not	PART
admet-276	44	41	been	be	AUX
admet-276	44	42	as	as	ADV
admet-276	44	43	remarkable	remarkable	ADJ
admet-276	44	44	as	as	ADP
admet-276	44	45	with	with	ADP
admet-276	44	46	small	small	ADJ
admet-276	44	47	-	-	PUNCT
admet-276	44	48	molecule	molecule	NOUN
admet-276	44	49	drugs	drug	NOUN
admet-276	44	50	,	,	PUNCT
admet-276	44	51	and	and	CCONJ
admet-276	44	52	the	the	DET
admet-276	44	53	types	type	NOUN
admet-276	44	54	of	of	ADP
admet-276	44	55	study	study	NOUN
admet-276	44	56	designs	design	NOUN
admet-276	44	57	used	use	VERB
admet-276	44	58	to	to	PART
admet-276	44	59	assess	assess	VERB
admet-276	44	60	tp	tp	NOUN
admet-276	44	61	and	and	CCONJ
admet-276	44	62	d	d	NOUN
admet-276	44	63	interactions	interaction	NOUN
admet-276	44	64	were	be	AUX
admet-276	44	65	thereby	thereby	ADV
admet-276	44	66	outlined	outline	VERB
admet-276	44	67	in	in	ADP
admet-276	44	68	cder	cder	NOUN
admet-276	44	69	’s	’s	PART
admet-276	44	70	special	special	ADJ
admet-276	44	71	subject	subject	NOUN
admet-276	44	72	on	on	ADP
admet-276	44	73	therapeutic	therapeutic	ADJ
admet-276	44	74	protein	protein	NOUN
admet-276	44	75	–	–	PUNCT
admet-276	44	76	drug	drug	NOUN
admet-276	44	77	interactions	interaction	NOUN
admet-276	44	78	and	and	CCONJ
admet-276	44	79	implications	implication	NOUN
admet-276	44	80	for	for	ADP
admet-276	44	81	drug	drug	NOUN
admet-276	44	82	development	development	NOUN
admet-276	44	83	[	[	X
admet-276	44	84	25	25	NUM
admet-276	44	85	]	]	PUNCT
admet-276	44	86	.	.	PUNCT
admet-276	45	1	on	on	ADP
admet-276	45	2	the	the	DET
admet-276	45	3	other	other	ADJ
admet-276	45	4	hand	hand	NOUN
admet-276	45	5	,	,	PUNCT
admet-276	45	6	for	for	ADP
admet-276	45	7	lms	lm	NOUN
admet-276	45	8	at	at	ADP
admet-276	45	9	early	early	ADJ
admet-276	45	10	stage	stage	NOUN
admet-276	45	11	,	,	PUNCT
admet-276	45	12	more	more	ADV
admet-276	45	13	extensive	extensive	ADJ
admet-276	45	14	in	in	ADP
admet-276	45	15	vitro	vitro	X
admet-276	45	16	characterizations	characterization	NOUN
admet-276	45	17	are	be	AUX
admet-276	45	18	required	require	VERB
admet-276	45	19	as	as	ADP
admet-276	45	20	an	an	DET
admet-276	45	21	example	example	NOUN
admet-276	45	22	of	of	ADP
admet-276	45	23	screening	screen	VERB
admet-276	45	24	cascade	cascade	NOUN
admet-276	45	25	depicted	depict	VERB
admet-276	45	26	in	in	ADP
admet-276	45	27	figure	figure	NOUN
admet-276	45	28	1	1	NUM
admet-276	45	29	.	.	PUNCT
admet-276	46	1	these	these	DET
admet-276	46	2	typical	typical	ADJ
admet-276	46	3	studies	study	NOUN
admet-276	46	4	include	include	VERB
admet-276	46	5	antibody	antibody	NOUN
admet-276	46	6	primary	primary	ADJ
admet-276	46	7	structure	structure	NOUN
admet-276	46	8	by	by	ADP
admet-276	46	9	chemical	chemical	NOUN
admet-276	46	10	sequencing	sequence	VERB
admet-276	46	11	(	(	PUNCT
admet-276	46	12	edman	edman	NOUN
admet-276	46	13	degradation	degradation	NOUN
admet-276	46	14	)	)	PUNCT
admet-276	46	15	as	as	ADV
admet-276	46	16	well	well	ADV
admet-276	46	17	as	as	ADP
admet-276	46	18	peptide	peptide	ADJ
admet-276	46	19	mapping	mapping	NOUN
admet-276	46	20	by	by	ADP
admet-276	46	21	means	mean	NOUN
admet-276	46	22	of	of	ADP
admet-276	46	23	esi	esi	PROPN
admet-276	46	24	-	-	PROPN
admet-276	46	25	ms	ms	NOUN
admet-276	46	26	and	and	CCONJ
admet-276	46	27	maldims	maldim	NOUN
admet-276	46	28	[	[	X
admet-276	46	29	26	26	NUM
admet-276	46	30	-	-	SYM
admet-276	46	31	28	28	NUM
admet-276	46	32	]	]	PUNCT
admet-276	46	33	;	;	PUNCT
admet-276	46	34	higher	high	ADJ
admet-276	46	35	order	order	NOUN
admet-276	46	36	structure	structure	NOUN
admet-276	46	37	by	by	ADP
admet-276	46	38	rp	rp	NOUN
admet-276	46	39	-	-	PUNCT
admet-276	46	40	hplc	hplc	NOUN
admet-276	46	41	–	–	PUNCT
admet-276	46	42	esi	esi	PROPN
admet-276	46	43	–	–	PUNCT
admet-276	46	44	ms	ms	PROPN
admet-276	46	45	,	,	PUNCT
admet-276	46	46	ellman	ellman	NOUN
admet-276	46	47	’s	’s	PART
admet-276	46	48	assay	assay	PROPN
admet-276	46	49	cd	cd	PROPN
admet-276	46	50	,	,	PUNCT
admet-276	46	51	ftir	ftir	PROPN
admet-276	46	52	,	,	PUNCT
admet-276	46	53	hydrogen	hydrogen	PROPN
admet-276	46	54	deuterium	deuterium	PROPN
admet-276	46	55	exchange	exchange	PROPN
admet-276	46	56	(	(	PUNCT
admet-276	46	57	hdx)-ms	hdx)-ms	NOUN
admet-276	46	58	and	and	CCONJ
admet-276	46	59	x	x	NOUN
admet-276	46	60	-	-	NOUN
admet-276	46	61	ray	ray	NOUN
admet-276	47	1	[	[	X
admet-276	47	2	28,29	28,29	NUM
admet-276	47	3	]	]	X
admet-276	47	4	;	;	PUNCT
admet-276	47	5	post	post	ADJ
admet-276	47	6	-	-	ADJ
admet-276	47	7	translational	translational	ADJ
admet-276	47	8	modifications	modification	NOUN
admet-276	47	9	(	(	PUNCT
admet-276	47	10	ptm	ptm	NOUN
admet-276	47	11	)	)	PUNCT
admet-276	47	12	and	and	CCONJ
admet-276	47	13	charge	charge	NOUN
admet-276	47	14	variants	variant	NOUN
admet-276	47	15	by	by	ADP
admet-276	47	16	msion	msion	ADJ
admet-276	47	17	-	-	PUNCT
admet-276	47	18	exchange	exchange	NOUN
admet-276	47	19	chromatography	chromatography	NOUN
admet-276	47	20	(	(	PUNCT
admet-276	47	21	iec	iec	PROPN
admet-276	47	22	)	)	PUNCT
admet-276	47	23	,	,	PUNCT
admet-276	47	24	hydrophobic	hydrophobic	NOUN
admet-276	47	25	interaction	interaction	NOUN
admet-276	47	26	chromatography	chromatography	NOUN
admet-276	47	27	(	(	PUNCT
admet-276	47	28	hic	hic	ADJ
admet-276	47	29	)	)	PUNCT
admet-276	47	30	,	,	PUNCT
admet-276	47	31	capillary	capillary	ADJ
admet-276	47	32	electrophoresis	electrophoresis	NOUN
admet-276	47	33	(	(	PUNCT
admet-276	47	34	ce	ce	PROPN
admet-276	47	35	)	)	PUNCT
admet-276	47	36	and	and	CCONJ
admet-276	47	37	isoelectric	isoelectric	ADJ
admet-276	47	38	focusing	focus	VERB
admet-276	47	39	(	(	PUNCT
admet-276	47	40	ief	ief	NOUN
admet-276	47	41	)	)	PUNCT
admet-276	48	1	[	[	X
admet-276	48	2	30	30	NUM
admet-276	48	3	]	]	PUNCT
admet-276	48	4	;	;	PUNCT
admet-276	48	5	glycan	glycan	VERB
admet-276	48	6	profile	profile	NOUN
admet-276	48	7	and	and	CCONJ
admet-276	48	8	variants	variant	NOUN
admet-276	48	9	and	and	CCONJ
admet-276	48	10	size	size	NOUN
admet-276	48	11	heterogeneity	heterogeneity	NOUN
admet-276	48	12	by	by	ADP
admet-276	48	13	hplc	hplc	NOUN
admet-276	48	14	-	-	PUNCT
admet-276	48	15	fluorescence	fluorescence	NOUN
admet-276	48	16	,	,	PUNCT
admet-276	48	17	size	size	NOUN
admet-276	48	18	-	-	PUNCT
admet-276	48	19	exclusion	exclusion	NOUN
admet-276	48	20	chromatography	chromatography	NOUN
admet-276	48	21	(	(	PUNCT
admet-276	48	22	sec	sec	PROPN
admet-276	48	23	)	)	PUNCT
admet-276	48	24	,	,	PUNCT
admet-276	48	25	native	native	ADJ
admet-276	48	26	gel	gel	NOUN
admet-276	48	27	,	,	PUNCT
admet-276	48	28	capillary	capillary	ADJ
admet-276	48	29	electrophoresis	electrophoresis	NOUN
admet-276	48	30	,	,	PUNCT
admet-276	48	31	rp	rp	NOUN
admet-276	48	32	-	-	PUNCT
admet-276	48	33	hplc	hplc	NOUN
admet-276	48	34	-	-	PUNCT
admet-276	48	35	ms	ms	NOUN
admet-276	48	36	and	and	CCONJ
admet-276	48	37	native	native	ADJ
admet-276	48	38	intact	intact	ADJ
admet-276	48	39	ms	ms	NOUN
admet-276	49	1	[	[	X
admet-276	49	2	31	31	NUM
admet-276	49	3	]	]	PUNCT
admet-276	49	4	,	,	PUNCT
admet-276	49	5	as	as	ADV
admet-276	49	6	well	well	ADV
admet-276	49	7	as	as	ADP
admet-276	49	8	solubility	solubility	NOUN
admet-276	49	9	measurement	measurement	NOUN
admet-276	49	10	by	by	ADP
admet-276	49	11	ultrafiltration	ultrafiltration	NOUN
admet-276	49	12	or	or	CCONJ
admet-276	49	13	peg	peg	NOUN
admet-276	49	14	-	-	PUNCT
admet-276	49	15	induced	induce	VERB
admet-276	49	16	precipitation	precipitation	NOUN
admet-276	49	17	methods	method	NOUN
admet-276	49	18	[	[	X
admet-276	49	19	32,33	32,33	NUM
admet-276	49	20	]	]	PUNCT
admet-276	49	21	.	.	PUNCT
admet-276	50	1	moreover	moreover	ADV
admet-276	50	2	,	,	PUNCT
admet-276	50	3	the	the	DET
admet-276	50	4	immunogenicity	immunogenicity	NOUN
admet-276	50	5	should	should	AUX
admet-276	50	6	be	be	AUX
admet-276	50	7	evaluated	evaluate	VERB
admet-276	50	8	for	for	ADP
admet-276	50	9	both	both	PRON
admet-276	50	10	antibody	antibody	NOUN
admet-276	50	11	and	and	CCONJ
admet-276	50	12	adcs	adc	VERB
admet-276	51	1	[	[	X
admet-276	51	2	34,35	34,35	NOUN
admet-276	51	3	]	]	PUNCT
admet-276	51	4	,	,	PUNCT
admet-276	51	5	but	but	CCONJ
admet-276	51	6	unnecessary	unnecessary	ADJ
admet-276	51	7	for	for	ADP
admet-276	51	8	sms	sms	PROPN
admet-276	51	9	.	.	PUNCT
admet-276	52	1	unlike	unlike	ADP
admet-276	52	2	the	the	DET
admet-276	52	3	antibody	antibody	NOUN
admet-276	52	4	,	,	PUNCT
admet-276	52	5	additional	additional	ADJ
admet-276	52	6	in	in	ADP
admet-276	52	7	vitro	vitro	X
admet-276	52	8	studies	study	NOUN
admet-276	52	9	of	of	ADP
admet-276	52	10	adc	adc	PROPN
admet-276	52	11	include	include	VERB
admet-276	52	12	drug	drug	NOUN
admet-276	52	13	antibody	antibody	NOUN
admet-276	52	14	ratio	ratio	NOUN
admet-276	52	15	(	(	PUNCT
admet-276	52	16	dar	dar	NOUN
admet-276	52	17	)	)	PUNCT
admet-276	52	18	characterizations	characterization	NOUN
admet-276	52	19	,	,	PUNCT
admet-276	52	20	conjugate	conjugate	ADJ
admet-276	52	21	site	site	NOUN
admet-276	52	22	analysis	analysis	NOUN
admet-276	52	23	,	,	PUNCT
admet-276	52	24	linker	linker	NOUN
admet-276	52	25	stability	stability	NOUN
admet-276	52	26	and	and	CCONJ
admet-276	52	27	toxin	toxin	NOUN
admet-276	52	28	evaluations	evaluation	NOUN
admet-276	52	29	as	as	SCONJ
admet-276	52	30	highlighted	highlight	VERB
admet-276	52	31	in	in	ADP
admet-276	52	32	figure	figure	NOUN
admet-276	52	33	1	1	NUM
admet-276	52	34	may	may	AUX
admet-276	52	35	be	be	AUX
admet-276	52	36	required	require	VERB
admet-276	52	37	.	.	PUNCT
admet-276	53	1	furthermore	furthermore	ADV
admet-276	53	2	,	,	PUNCT
admet-276	53	3	absorption	absorption	NOUN
admet-276	53	4	needs	need	VERB
admet-276	53	5	to	to	PART
admet-276	53	6	be	be	AUX
admet-276	53	7	understood	understand	VERB
admet-276	53	8	as	as	ADV
admet-276	53	9	well	well	ADV
admet-276	53	10	if	if	SCONJ
admet-276	53	11	lms	lm	NOUN
admet-276	53	12	are	be	AUX
admet-276	53	13	targeting	target	VERB
admet-276	53	14	for	for	ADP
admet-276	53	15	an	an	DET
admet-276	53	16	sc	sc	PROPN
admet-276	53	17	administration	administration	NOUN
admet-276	53	18	.	.	PUNCT
admet-276	54	1	despite	despite	SCONJ
admet-276	54	2	distinct	distinct	ADJ
admet-276	54	3	characteristics	characteristic	NOUN
admet-276	54	4	and	and	CCONJ
admet-276	54	5	differences	difference	NOUN
admet-276	54	6	of	of	ADP
admet-276	54	7	in	in	ADP
admet-276	54	8	vitro	vitro	X
admet-276	54	9	testing	testing	NOUN
admet-276	54	10	between	between	ADP
admet-276	54	11	antibody	antibody	NOUN
admet-276	54	12	and	and	CCONJ
admet-276	54	13	adcs	adcs	ADJ
admet-276	54	14	and	and	CCONJ
admet-276	54	15	sms	sms	PROPN
admet-276	54	16	as	as	SCONJ
admet-276	54	17	shown	show	VERB
admet-276	54	18	in	in	ADP
admet-276	54	19	table	table	NOUN
admet-276	54	20	1	1	NUM
admet-276	54	21	and	and	CCONJ
admet-276	54	22	figure	figure	VERB
admet-276	54	23	1	1	NUM
admet-276	54	24	,	,	PUNCT
admet-276	54	25	similar	similar	ADJ
admet-276	54	26	principle	principle	NOUN
admet-276	54	27	of	of	ADP
admet-276	54	28	in	in	ADP
admet-276	54	29	vivo	vivo	ADJ
admet-276	54	30	pk	pk	NOUN
admet-276	54	31	studies	study	NOUN
admet-276	54	32	including	include	VERB
admet-276	54	33	mass	mass	NOUN
admet-276	54	34	balance	balance	NOUN
admet-276	54	35	and	and	CCONJ
admet-276	54	36	elimination	elimination	NOUN
admet-276	54	37	as	as	ADV
admet-276	54	38	well	well	ADV
admet-276	54	39	as	as	ADP
admet-276	54	40	safety	safety	NOUN
admet-276	54	41	evaluations	evaluation	NOUN
admet-276	54	42	for	for	ADP
admet-276	54	43	sms	sm	NOUN
admet-276	54	44	are	be	AUX
admet-276	54	45	generally	generally	ADV
admet-276	54	46	applicable	applicable	ADJ
admet-276	54	47	to	to	ADP
admet-276	54	48	both	both	CCONJ
admet-276	54	49	antibody	antibody	NOUN
admet-276	54	50	and	and	CCONJ
admet-276	54	51	adcs	adcs	ADJ
admet-276	54	52	.	.	PUNCT
admet-276	55	1	however	however	ADV
admet-276	55	2	,	,	PUNCT
admet-276	55	3	different	different	ADJ
admet-276	55	4	bioanalytical	bioanalytical	ADJ
admet-276	55	5	methods	method	NOUN
admet-276	55	6	have	have	VERB
admet-276	55	7	to	to	PART
admet-276	55	8	be	be	AUX
admet-276	55	9	applied	apply	VERB
admet-276	55	10	for	for	ADP
admet-276	55	11	antibody	antibody	NOUN
admet-276	55	12	and	and	CCONJ
admet-276	55	13	adcs	adc	NOUN
admet-276	55	14	,	,	PUNCT
admet-276	55	15	which	which	PRON
admet-276	55	16	will	will	AUX
admet-276	55	17	be	be	AUX
admet-276	55	18	discussed	discuss	VERB
admet-276	55	19	in	in	ADP
admet-276	55	20	more	more	ADJ
admet-276	55	21	details	detail	NOUN
admet-276	55	22	in	in	ADP
admet-276	55	23	bioanalytical	bioanalytical	ADJ
admet-276	55	24	section	section	NOUN
admet-276	55	25	.	.	PUNCT
admet-276	56	1	hong	hong	PROPN
admet-276	56	2	wan	wan	PROPN
admet-276	56	3	admet	admet	PROPN
admet-276	56	4	&	&	CCONJ
admet-276	56	5	dmpk	dmpk	PROPN
admet-276	56	6	4(1	4(1	NOUN
admet-276	56	7	)	)	PUNCT
admet-276	56	8	(	(	PUNCT
admet-276	56	9	2016	2016	NUM
admet-276	56	10	)	)	PUNCT
admet-276	56	11	1	1	NUM
admet-276	56	12	-	-	SYM
admet-276	56	13	22	22	NUM
admet-276	56	14	4	4	NUM
admet-276	56	15	table	table	NOUN
admet-276	56	16	1	1	NUM
admet-276	56	17	.	.	PUNCT
admet-276	56	18	characteristic	characteristic	ADJ
admet-276	56	19	comparison	comparison	NOUN
admet-276	56	20	of	of	ADP
admet-276	56	21	small	small	ADJ
admet-276	56	22	molecules	molecule	NOUN
admet-276	56	23	(	(	PUNCT
admet-276	56	24	sms	sms	PROPN
admet-276	56	25	)	)	PUNCT
admet-276	56	26	and	and	CCONJ
admet-276	56	27	large	large	ADJ
admet-276	56	28	molecules	molecule	NOUN
admet-276	56	29	(	(	PUNCT
admet-276	56	30	lms	lm	NOUN
admet-276	56	31	)	)	PUNCT
admet-276	56	32	*	*	PUNCT
admet-276	57	1	*	*	PUNCT
admet-276	57	2	modified	modify	VERB
admet-276	57	3	from	from	ADP
admet-276	57	4	references	reference	NOUN
admet-276	57	5	[	[	X
admet-276	57	6	8	8	NUM
admet-276	57	7	-	-	SYM
admet-276	57	8	10	10	NUM
admet-276	57	9	]	]	PUNCT
admet-276	57	10	.	.	PUNCT
admet-276	58	1	sms	sms	PROPN
admet-276	58	2	biologics	biologic	NOUN
admet-276	58	3	or	or	CCONJ
admet-276	58	4	lms	lms	PROPN
admet-276	58	5	mabs	mabs	PROPN
admet-276	58	6	adc	adc	PROPN
admet-276	58	7	mw	mw	X
admet-276	58	8	~	~	PUNCT
admet-276	58	9	200	200	NUM
admet-276	58	10	-	-	SYM
admet-276	58	11	500	500	NUM
admet-276	58	12	～	～	NUM
admet-276	58	13	150	150	NUM
admet-276	58	14	kda	kda	NOUN
admet-276	58	15	(	(	PUNCT
admet-276	58	16	typically	typically	ADV
admet-276	58	17	)	)	PUNCT
admet-276	58	18	～	～	PROPN
admet-276	58	19	150	150	NUM
admet-276	58	20	kda	kda	NOUN
admet-276	58	21	(	(	PUNCT
admet-276	58	22	typically	typically	ADV
admet-276	58	23	)	)	PUNCT
admet-276	58	24	test	test	NOUN
admet-276	58	25	article	article	NOUN
admet-276	58	26	chemical	chemical	NOUN
admet-276	58	27	protein	protein	NOUN
admet-276	58	28	conjugate	conjugate	ADJ
admet-276	58	29	(	(	PUNCT
admet-276	58	30	protein	protein	NOUN
admet-276	58	31	-	-	PUNCT
admet-276	58	32	chemical	chemical	NOUN
admet-276	58	33	)	)	PUNCT
admet-276	58	34	physicochemical	physicochemical	ADJ
admet-276	58	35	properties	property	NOUN
admet-276	58	36	mostly	mostly	ADV
admet-276	58	37	well	well	ADV
admet-276	58	38	-	-	PUNCT
admet-276	58	39	defined	define	VERB
admet-276	58	40	physicochemical	physicochemical	ADJ
admet-276	58	41	properties	property	NOUN
admet-276	58	42	complex	complex	ADJ
admet-276	58	43	physicochemical	physicochemical	ADJ
admet-276	58	44	properties	property	NOUN
admet-276	58	45	(	(	PUNCT
admet-276	58	46	e.g.	e.g.	ADV
admet-276	58	47	tertiary	tertiary	ADJ
admet-276	58	48	structure	structure	NOUN
admet-276	58	49	,	,	PUNCT
admet-276	58	50	stability	stability	NOUN
admet-276	58	51	,	,	PUNCT
admet-276	58	52	ptm	ptm	NOUN
admet-276	58	53	)	)	PUNCT
admet-276	58	54	antibody	antibody	NOUN
admet-276	58	55	+	+	CCONJ
admet-276	58	56	toxin	toxin	NOUN
admet-276	58	57	adme	adme	NOUN
admet-276	58	58	tools	tool	VERB
admet-276	58	59	available/	available/	NUM
admet-276	58	60	extensive	extensive	ADJ
admet-276	58	61	adme	adme	NOUN
admet-276	58	62	understanding	understand	VERB
admet-276	58	63	understanding	understanding	NOUN
admet-276	58	64	of	of	ADP
admet-276	58	65	adme	adme	NOUN
admet-276	58	66	still	still	ADV
admet-276	58	67	evolving	evolve	VERB
admet-276	58	68	understanding	understanding	NOUN
admet-276	58	69	of	of	ADP
admet-276	58	70	adme	adme	NOUN
admet-276	58	71	still	still	ADV
admet-276	58	72	evolving	evolve	VERB
admet-276	58	73	dosing	dose	VERB
admet-276	58	74	route	route	NOUN
admet-276	58	75	oral	oral	ADJ
admet-276	58	76	often	often	ADV
admet-276	58	77	possible	possible	ADJ
admet-276	58	78	usually	usually	ADV
admet-276	58	79	parenterally	parenterally	ADV
admet-276	58	80	(	(	PUNCT
admet-276	58	81	iv	iv	PROPN
admet-276	58	82	,	,	PUNCT
admet-276	58	83	sc	sc	PROPN
admet-276	58	84	,	,	PUNCT
admet-276	58	85	and	and	CCONJ
admet-276	58	86	i	i	PRON
admet-276	58	87	m	m	PROPN
admet-276	58	88	)	)	PUNCT
admet-276	58	89	,	,	PUNCT
admet-276	58	90	intravitreal	intravitreal	ADJ
admet-276	58	91	injection	injection	NOUN
admet-276	58	92	usually	usually	ADV
admet-276	58	93	parenterally	parenterally	ADV
admet-276	58	94	(	(	PUNCT
admet-276	58	95	iv	iv	PROPN
admet-276	58	96	,	,	PUNCT
admet-276	58	97	sc	sc	PROPN
admet-276	58	98	,	,	PUNCT
admet-276	58	99	and	and	CCONJ
admet-276	58	100	i	i	PRON
admet-276	58	101	m	m	VERB
admet-276	58	102	)	)	PUNCT
admet-276	58	103	dose	dose	NOUN
admet-276	58	104	interval	interval	NOUN
admet-276	58	105	daily	daily	ADV
admet-276	58	106	(	(	PUNCT
admet-276	58	107	typically	typically	ADV
admet-276	58	108	)	)	PUNCT
admet-276	58	109	intermittent	intermittent	ADJ
admet-276	58	110	dosing	dose	VERB
admet-276	58	111	intermittent	intermittent	ADJ
admet-276	58	112	dosing	dose	VERB
admet-276	58	113	half	half	ADJ
admet-276	58	114	-	-	PUNCT
admet-276	58	115	life	life	NOUN
admet-276	58	116	(	(	PUNCT
admet-276	58	117	t1/2	t1/2	NOUN
admet-276	58	118	)	)	PUNCT
admet-276	59	1	short	short	ADJ
admet-276	59	2	(	(	PUNCT
admet-276	59	3	typically	typically	ADV
admet-276	59	4	several	several	ADJ
admet-276	59	5	to	to	PART
admet-276	59	6	24	24	NUM
admet-276	59	7	hrs	hrs	NOUN
admet-276	59	8	)	)	PUNCT
admet-276	60	1	long	long	ADV
admet-276	60	2	(	(	PUNCT
admet-276	60	3	typically	typically	ADV
admet-276	60	4	days	day	NOUN
admet-276	60	5	or	or	CCONJ
admet-276	60	6	weeks	week	NOUN
admet-276	60	7	)	)	PUNCT
admet-276	61	1	long	long	ADV
admet-276	61	2	but	but	CCONJ
admet-276	61	3	slightly	slightly	ADV
admet-276	61	4	shorter	short	ADJ
admet-276	61	5	than	than	ADP
admet-276	61	6	antibody	antibody	NOUN
admet-276	61	7	alone	alone	ADJ
admet-276	61	8	distribution	distribution	NOUN
admet-276	61	9	(	(	PUNCT
admet-276	61	10	vd	vd	NOUN
admet-276	61	11	)	)	PUNCT
admet-276	61	12	high	high	ADJ
admet-276	61	13	vd	vd	NOUN
admet-276	61	14	,	,	PUNCT
admet-276	61	15	distribution	distribution	NOUN
admet-276	61	16	to	to	ADP
admet-276	61	17	organs	organ	NOUN
admet-276	61	18	/	/	SYM
admet-276	61	19	tissues	tissue	NOUN
admet-276	61	20	potential	potential	ADJ
admet-276	61	21	substrate	substrate	NOUN
admet-276	61	22	of	of	ADP
admet-276	61	23	transporters	transporter	NOUN
admet-276	61	24	lower	low	ADJ
admet-276	61	25	vd	vd	NOUN
admet-276	61	26	,	,	PUNCT
admet-276	61	27	usually	usually	ADV
admet-276	61	28	limited	limit	VERB
admet-276	61	29	to	to	ADP
admet-276	61	30	plasma	plasma	NOUN
admet-276	61	31	and/	and/	PROPN
admet-276	61	32	or	or	CCONJ
admet-276	61	33	extracellular	extracellular	ADJ
admet-276	61	34	fluids	fluid	NOUN
admet-276	61	35	lower	low	ADJ
admet-276	61	36	vd	vd	NOUN
admet-276	61	37	,	,	PUNCT
admet-276	61	38	mainly	mainly	ADV
admet-276	61	39	target	target	VERB
admet-276	61	40	dependent	dependent	ADJ
admet-276	61	41	metabolism	metabolism	NOUN
admet-276	61	42	pathway	pathway	NOUN
admet-276	61	43	mainly	mainly	ADV
admet-276	61	44	by	by	ADP
admet-276	61	45	cyp	cyp	ADJ
admet-276	61	46	enzymes	enzyme	NOUN
admet-276	61	47	and	and	CCONJ
admet-276	61	48	phase	phase	NOUN
admet-276	61	49	ii	ii	NOUN
admet-276	61	50	enzymes	enzyme	NOUN
admet-276	61	51	,	,	PUNCT
admet-276	61	52	metabolized	metabolize	VERB
admet-276	61	53	to	to	ADP
admet-276	61	54	nonactive	nonactive	ADJ
admet-276	61	55	and	and	CCONJ
admet-276	61	56	active	active	ADJ
admet-276	61	57	metabolites	metabolite	NOUN
admet-276	61	58	catabolism	catabolism	NOUN
admet-276	61	59	degraded	degrade	VERB
admet-276	61	60	to	to	ADP
admet-276	61	61	peptides	peptide	NOUN
admet-276	61	62	or	or	CCONJ
admet-276	61	63	amino	amino	ADJ
admet-276	61	64	acids	acid	NOUN
admet-276	61	65	both	both	CCONJ
admet-276	61	66	catabolism	catabolism	NOUN
admet-276	61	67	and	and	CCONJ
admet-276	61	68	metabolism	metabolism	NOUN
admet-276	61	69	drug	drug	NOUN
admet-276	61	70	metabolite	metabolite	NOUN
admet-276	61	71	safety	safety	NOUN
admet-276	61	72	evaluation	evaluation	NOUN
admet-276	62	1	yes	yes	INTJ
admet-276	62	2	no	no	DET
admet-276	62	3	toxin	toxin	NOUN
admet-276	62	4	and	and	CCONJ
admet-276	62	5	released	release	VERB
admet-276	62	6	drug	drug	NOUN
admet-276	62	7	catabolites	catabolite	NOUN
admet-276	62	8	(	(	PUNCT
admet-276	62	9	may	may	AUX
admet-276	62	10	be	be	AUX
admet-276	62	11	concerned	concern	VERB
admet-276	62	12	)	)	PUNCT
admet-276	62	13	excretion	excretion	NOUN
admet-276	62	14	mainly	mainly	ADV
admet-276	62	15	biliary	biliary	ADJ
admet-276	62	16	and	and	CCONJ
admet-276	62	17	renal	renal	ADJ
admet-276	62	18	excretion	excretion	NOUN
admet-276	62	19	mostly	mostly	ADV
admet-276	62	20	recycled	recycle	VERB
admet-276	62	21	by	by	ADP
admet-276	62	22	body	body	NOUN
admet-276	62	23	both	both	DET
admet-276	62	24	clearance	clearance	NOUN
admet-276	62	25	(	(	PUNCT
admet-276	62	26	cl	cl	NOUN
admet-276	62	27	)	)	PUNCT
admet-276	62	28	mostly	mostly	ADV
admet-276	62	29	linear	linear	PROPN
admet-276	62	30	pk	pk	NOUN
admet-276	62	31	;	;	PUNCT
admet-276	62	32	non	non	ADJ
admet-276	62	33	-	-	ADJ
admet-276	62	34	linearity	linearity	NOUN
admet-276	62	35	mainly	mainly	ADV
admet-276	62	36	due	due	ADP
admet-276	62	37	to	to	ADP
admet-276	62	38	saturation	saturation	NOUN
admet-276	62	39	of	of	ADP
admet-276	62	40	metabolic	metabolic	NOUN
admet-276	62	41	pathways	pathway	NOUN
admet-276	62	42	slow	slow	ADJ
admet-276	62	43	clearance	clearance	NOUN
admet-276	62	44	lower	low	ADJ
admet-276	62	45	clearance	clearance	NOUN
admet-276	62	46	,	,	PUNCT
admet-276	62	47	but	but	CCONJ
admet-276	62	48	slightly	slightly	ADV
admet-276	62	49	higher	high	ADJ
admet-276	62	50	clearance	clearance	NOUN
admet-276	62	51	than	than	ADP
admet-276	62	52	antibody	antibody	NOUN
admet-276	62	53	potency	potency	NOUN
admet-276	62	54	and	and	CCONJ
admet-276	62	55	selectivity	selectivity	NOUN
admet-276	62	56	generally	generally	ADV
admet-276	62	57	less	less	ADV
admet-276	62	58	selective	selective	ADJ
admet-276	62	59	high	high	ADJ
admet-276	62	60	selectivity	selectivity	NOUN
admet-276	62	61	(	(	PUNCT
admet-276	62	62	affinity/	affinity/	NUM
admet-276	62	63	potency	potency	NOUN
admet-276	62	64	)	)	PUNCT
admet-276	62	65	high	high	ADJ
admet-276	62	66	selectivity	selectivity	NOUN
admet-276	62	67	(	(	PUNCT
admet-276	62	68	affinity/	affinity/	NUM
admet-276	62	69	potency	potency	NOUN
admet-276	62	70	)	)	PUNCT
admet-276	62	71	pk	pk	NOUN
admet-276	62	72	analytes	analyte	VERB
admet-276	62	73	drug	drug	NOUN
admet-276	62	74	and	and	CCONJ
admet-276	62	75	metabolites	metabolite	NOUN
admet-276	62	76	antibody	antibody	NOUN
admet-276	62	77	and	and	CCONJ
admet-276	62	78	ada	ada	PROPN
admet-276	62	79	adc	adc	PROPN
admet-276	62	80	or	or	CCONJ
admet-276	62	81	conjugated	conjugate	VERB
admet-276	62	82	drug	drug	NOUN
admet-276	62	83	,	,	PUNCT
admet-276	62	84	total	total	ADJ
admet-276	62	85	antibody	antibody	NOUN
admet-276	62	86	,	,	PUNCT
admet-276	62	87	and	and	CCONJ
admet-276	62	88	unconjugated	unconjugated	ADJ
admet-276	62	89	toxin	toxin	NOUN
admet-276	62	90	/	/	SYM
admet-276	62	91	catabolites	catabolite	NOUN
admet-276	62	92	,	,	PUNCT
admet-276	62	93	ata	ata	INTJ
admet-276	62	94	pk	pk	NOUN
admet-276	62	95	bioanalysis	bioanalysis	PROPN
admet-276	62	96	lc	lc	PROPN
admet-276	62	97	-	-	PUNCT
admet-276	62	98	ms	ms	PROPN
admet-276	62	99	/	/	SYM
admet-276	62	100	ms	ms	PROPN
admet-276	62	101	methods	method	NOUN
admet-276	62	102	mostly	mostly	ADV
admet-276	62	103	elisa	elisa	VERB
admet-276	62	104	(	(	PUNCT
admet-276	62	105	total	total	ADJ
admet-276	62	106	antibody	antibody	NOUN
admet-276	62	107	)	)	PUNCT
admet-276	62	108	,	,	PUNCT
admet-276	62	109	recently	recently	ADV
admet-276	62	110	with	with	ADP
admet-276	62	111	increased	increase	VERB
admet-276	62	112	lcms	lcms	PROPN
admet-276	62	113	/	/	SYM
admet-276	62	114	ms	ms	PROPN
admet-276	62	115	applications	application	NOUN
admet-276	62	116	hybrid	hybrid	NOUN
admet-276	62	117	of	of	ADP
admet-276	62	118	elisa	elisa	NOUN
admet-276	62	119	(	(	PUNCT
admet-276	62	120	total	total	ADJ
admet-276	62	121	antibody	antibody	NOUN
admet-276	62	122	,	,	PUNCT
admet-276	62	123	adc	adc	PROPN
admet-276	62	124	)	)	PUNCT
admet-276	62	125	,	,	PUNCT
admet-276	62	126	high	high	ADJ
admet-276	62	127	resolution	resolution	NOUN
admet-276	62	128	lc	lc	PROPN
admet-276	62	129	-	-	PUNCT
admet-276	62	130	ms	ms	PROPN
admet-276	62	131	(	(	PUNCT
admet-276	62	132	dar	dar	NOUN
admet-276	62	133	)	)	PUNCT
admet-276	62	134	and	and	CCONJ
admet-276	62	135	highly	highly	ADV
admet-276	62	136	selective	selective	ADJ
admet-276	62	137	lc-/ms	lc-/ms	PROPN
admet-276	62	138	/	/	SYM
admet-276	62	139	ms	ms	PROPN
admet-276	62	140	(	(	PUNCT
admet-276	62	141	un	un	ADJ
admet-276	62	142	-	-	ADJ
admet-276	62	143	conjugated	conjugated	ADJ
admet-276	62	144	toxin	toxin	NOUN
admet-276	62	145	/	/	SYM
admet-276	62	146	catabolites	catabolite	NOUN
admet-276	62	147	)	)	PUNCT
admet-276	62	148	pd	pd	PROPN
admet-276	62	149	short	short	ADJ
admet-276	62	150	acting	act	VERB
admet-276	62	151	long	long	ADV
admet-276	62	152	acting	act	VERB
admet-276	62	153	long	long	ADV
admet-276	62	154	acting	act	VERB
admet-276	62	155	pk	pk	PROPN
admet-276	62	156	/	/	SYM
admet-276	62	157	pd	pd	PROPN
admet-276	62	158	pk	pk	NOUN
admet-276	62	159	usually	usually	ADV
admet-276	62	160	not	not	PART
admet-276	62	161	driven	drive	VERB
admet-276	62	162	by	by	ADP
admet-276	62	163	pd	pd	PROPN
admet-276	62	164	due	due	ADP
admet-276	62	165	to	to	ADP
admet-276	62	166	dominance	dominance	NOUN
admet-276	62	167	of	of	ADP
admet-276	62	168	non	non	ADJ
admet-276	62	169	-	-	ADJ
admet-276	62	170	target	target	ADJ
admet-276	62	171	mediated	mediate	VERB
admet-276	62	172	binding	bind	VERB
admet-276	62	173	pk	pk	NOUN
admet-276	62	174	and	and	CCONJ
admet-276	62	175	pd	pd	PROPN
admet-276	62	176	mechanistically	mechanistically	ADV
admet-276	62	177	connected	connect	VERB
admet-276	62	178	(	(	PUNCT
admet-276	62	179	tmdd	tmdd	ADJ
admet-276	62	180	)	)	PUNCT
admet-276	62	181	pk	pk	NOUN
admet-276	62	182	and	and	CCONJ
admet-276	62	183	pd	pd	PROPN
admet-276	63	1	mechanistically	mechanistically	ADV
admet-276	63	2	connected	connect	VERB
admet-276	63	3	(	(	PUNCT
admet-276	63	4	tmdd	tmdd	ADV
admet-276	63	5	)	)	PUNCT
admet-276	63	6	ddi	ddi	VERB
admet-276	63	7	many	many	ADJ
admet-276	63	8	examples	example	NOUN
admet-276	63	9	and	and	CCONJ
admet-276	63	10	pk	pk	NOUN
admet-276	63	11	and/or	and/or	CCONJ
admet-276	63	12	pd	pd	PROPN
admet-276	63	13	related	relate	VERB
admet-276	63	14	(	(	PUNCT
admet-276	63	15	by	by	ADP
admet-276	63	16	cyp	cyp	ADJ
admet-276	63	17	enzymes	enzyme	NOUN
admet-276	63	18	or	or	CCONJ
admet-276	63	19	transporters	transporter	NOUN
admet-276	63	20	)	)	PUNCT
admet-276	63	21	sparse	sparse	ADJ
admet-276	63	22	examples	example	NOUN
admet-276	63	23	and	and	CCONJ
admet-276	63	24	mostly	mostly	ADV
admet-276	63	25	pd	pd	NOUN
admet-276	63	26	related	relate	VERB
admet-276	63	27	sparse	sparse	ADJ
admet-276	63	28	examples	example	NOUN
admet-276	63	29	and	and	CCONJ
admet-276	63	30	mostly	mostly	ADV
admet-276	63	31	pd	pd	X
admet-276	63	32	related	relate	VERB
admet-276	63	33	toxin	toxin	NOUN
admet-276	63	34	or	or	CCONJ
admet-276	63	35	released	release	VERB
admet-276	63	36	toxin	toxin	NOUN
admet-276	63	37	/	/	SYM
admet-276	63	38	catabolites	catabolite	NOUN
admet-276	63	39	(	(	PUNCT
admet-276	63	40	should	should	AUX
admet-276	63	41	be	be	AUX
admet-276	63	42	concerned	concern	VERB
admet-276	63	43	)	)	PUNCT
admet-276	64	1	herg	herg	PROPN
admet-276	65	1	yes	yes	INTJ
admet-276	65	2	no	no	INTJ
admet-276	66	1	no	no	DET
admet-276	66	2	immunogenicity	immunogenicity	NOUN
admet-276	67	1	no	no	INTJ
admet-276	67	2	yes	yes	INTJ
admet-276	67	3	yes	yes	INTJ
admet-276	67	4	toxicity	toxicity	NOUN
admet-276	67	5	on	on	ADP
admet-276	67	6	-	-	PUNCT
admet-276	67	7	and	and	CCONJ
admet-276	67	8	off	off	ADP
admet-276	67	9	-	-	PUNCT
admet-276	67	10	target	target	NOUN
admet-276	67	11	related	relate	VERB
admet-276	67	12	toxicity	toxicity	NOUN
admet-276	67	13	typically	typically	ADV
admet-276	67	14	exaggerated	exaggerated	ADJ
admet-276	67	15	pharmacology	pharmacology	NOUN
admet-276	67	16	typically	typically	ADV
admet-276	67	17	antigen	antigen	ADV
admet-276	67	18	-	-	PUNCT
admet-276	67	19	independent	independent	ADJ
admet-276	67	20	can	can	AUX
admet-276	67	21	be	be	AUX
admet-276	67	22	more	more	ADV
admet-276	67	23	toxic	toxic	ADJ
admet-276	67	24	than	than	ADP
admet-276	67	25	antibody	antibody	NOUN
admet-276	67	26	due	due	ADP
admet-276	67	27	to	to	ADP
admet-276	67	28	toxin	toxin	NOUN
admet-276	67	29	formulation	formulation	NOUN
admet-276	67	30	complex	complex	NOUN
admet-276	67	31	and	and	CCONJ
admet-276	67	32	diverse	diverse	ADJ
admet-276	67	33	simple	simple	ADJ
admet-276	67	34	formulation	formulation	NOUN
admet-276	67	35	simple	simple	ADJ
admet-276	67	36	formulation	formulation	NOUN
admet-276	67	37	api	api	NOUN
admet-276	67	38	/	/	SYM
admet-276	67	39	production	production	NOUN
admet-276	67	40	process	process	NOUN
admet-276	67	41	synthesized	synthesize	VERB
admet-276	67	42	(	(	PUNCT
admet-276	67	43	uniform	uniform	ADJ
admet-276	67	44	single	single	ADJ
admet-276	67	45	entity	entity	NOUN
admet-276	67	46	)	)	PUNCT
admet-276	67	47	generics	generic	NOUN
admet-276	67	48	,	,	PUNCT
admet-276	67	49	bioequivalence	bioequivalence	NOUN
admet-276	67	50	culture	culture	NOUN
admet-276	67	51	-	-	PUNCT
admet-276	67	52	derived	derive	VERB
admet-276	67	53	(	(	PUNCT
admet-276	67	54	generally	generally	ADV
admet-276	67	55	nonuniform	nonuniform	ADJ
admet-276	67	56	)	)	PUNCT
admet-276	67	57	no	no	DET
admet-276	67	58	generics	generic	NOUN
admet-276	67	59	,	,	PUNCT
admet-276	67	60	biosimilar	biosimilar	NOUN
admet-276	67	61	or	or	CCONJ
admet-276	67	62	comparability	comparability	NOUN
admet-276	67	63	both	both	PRON
admet-276	67	64	+	+	CCONJ
admet-276	67	65	conjugation	conjugation	NOUN
admet-276	67	66	(	(	PUNCT
admet-276	67	67	mixtures	mixture	NOUN
admet-276	67	68	of	of	ADP
admet-276	67	69	adcs	adcs	NOUN
admet-276	67	70	with	with	ADP
admet-276	67	71	different	different	ADJ
admet-276	67	72	dar	dar	NOUN
admet-276	67	73	no	no	DET
admet-276	67	74	generics	generic	NOUN
admet-276	67	75	,	,	PUNCT
admet-276	67	76	biosimilar	biosimilar	NOUN
admet-276	67	77	or	or	CCONJ
admet-276	67	78	comparability	comparability	NOUN
admet-276	67	79	admet	admet	NOUN
admet-276	67	80	&	&	CCONJ
admet-276	67	81	dmpk	dmpk	PROPN
admet-276	67	82	4(1	4(1	NOUN
admet-276	67	83	)	)	PUNCT
admet-276	67	84	(	(	PUNCT
admet-276	67	85	2016	2016	NUM
admet-276	67	86	)	)	PUNCT
admet-276	67	87	1	1	NUM
admet-276	67	88	-	-	SYM
admet-276	67	89	22	22	NUM
admet-276	67	90	adme	adme	NOUN
admet-276	67	91	testing	testing	NOUN
admet-276	67	92	of	of	ADP
admet-276	67	93	large	large	ADJ
admet-276	67	94	biologics	biologic	NOUN
admet-276	67	95	doi	doi	NOUN
admet-276	67	96	:	:	PUNCT
admet-276	67	97	10.5599	10.5599	NUM
admet-276	67	98	/	/	SYM
admet-276	67	99	admet.4.1.276	admet.4.1.276	NUM
admet-276	67	100	5	5	NUM
admet-276	67	101	figure	figure	NOUN
admet-276	67	102	1	1	NUM
admet-276	67	103	.	.	PUNCT
admet-276	67	104	typical	typical	ADJ
admet-276	67	105	adme	adme	NOUN
admet-276	67	106	/	/	SYM
admet-276	67	107	tox	tox	NOUN
admet-276	67	108	studies	study	NOUN
admet-276	67	109	for	for	ADP
admet-276	67	110	sm	sm	PROPN
admet-276	67	111	and	and	CCONJ
admet-276	67	112	antibody	antibody	NOUN
admet-276	67	113	and	and	CCONJ
admet-276	67	114	adc	adc	PROPN
admet-276	67	115	2.1	2.1	NUM
admet-276	67	116	.	.	PUNCT
admet-276	68	1	adme	adme	NOUN
admet-276	68	2	testing	testing	NOUN
admet-276	68	3	of	of	ADP
admet-276	68	4	mabs	mab	NOUN
admet-276	68	5	fundamental	fundamental	ADJ
admet-276	68	6	adme	adme	NOUN
admet-276	68	7	characteristics	characteristic	NOUN
admet-276	68	8	and	and	CCONJ
admet-276	68	9	pk	pk	NOUN
admet-276	68	10	behaviors	behavior	NOUN
admet-276	68	11	of	of	ADP
admet-276	68	12	biologics	biologic	NOUN
admet-276	68	13	including	include	VERB
admet-276	68	14	therapeutic	therapeutic	ADJ
admet-276	68	15	proteins	protein	NOUN
admet-276	68	16	and	and	CCONJ
admet-276	68	17	mabs	mab	NOUN
admet-276	68	18	have	have	AUX
admet-276	68	19	extensively	extensively	ADV
admet-276	68	20	been	be	AUX
admet-276	68	21	reviewed	review	VERB
admet-276	68	22	recently	recently	ADV
admet-276	68	23	[	[	X
admet-276	68	24	2,11,25,36	2,11,25,36	NUM
admet-276	68	25	-	-	SYM
admet-276	68	26	39	39	NUM
admet-276	68	27	]	]	PUNCT
admet-276	68	28	.	.	PUNCT
admet-276	69	1	currently	currently	ADV
admet-276	69	2	,	,	PUNCT
admet-276	69	3	there	there	PRON
admet-276	69	4	is	be	VERB
admet-276	69	5	lack	lack	NOUN
admet-276	69	6	of	of	ADP
admet-276	69	7	validated	validate	VERB
admet-276	69	8	in	in	ADP
admet-276	69	9	vitro	vitro	X
admet-276	69	10	adme	adme	NOUN
admet-276	69	11	models	model	NOUN
admet-276	69	12	for	for	ADP
admet-276	69	13	mabs	mab	NOUN
admet-276	69	14	.	.	PUNCT
admet-276	70	1	in	in	ADP
admet-276	70	2	addition	addition	NOUN
admet-276	70	3	to	to	ADP
admet-276	70	4	extensive	extensive	ADJ
admet-276	70	5	characterization	characterization	NOUN
admet-276	70	6	of	of	ADP
admet-276	70	7	antibody	antibody	NOUN
admet-276	70	8	as	as	SCONJ
admet-276	70	9	depicted	depict	VERB
admet-276	70	10	in	in	ADP
admet-276	70	11	figure	figure	NOUN
admet-276	70	12	1	1	NUM
admet-276	70	13	,	,	PUNCT
admet-276	70	14	the	the	DET
admet-276	70	15	major	major	ADJ
admet-276	70	16	adme	adme	NOUN
admet-276	70	17	testing	testing	NOUN
admet-276	70	18	of	of	ADP
admet-276	70	19	mabs	mab	NOUN
admet-276	70	20	relies	rely	VERB
admet-276	70	21	on	on	ADP
admet-276	70	22	in	in	ADP
admet-276	70	23	vivo	vivo	ADJ
admet-276	70	24	studies	study	NOUN
admet-276	70	25	such	such	ADJ
admet-276	70	26	as	as	ADP
admet-276	70	27	pk	pk	NOUN
admet-276	70	28	and	and	CCONJ
admet-276	70	29	safety	safety	NOUN
admet-276	70	30	evaluations	evaluation	NOUN
admet-276	70	31	on	on	ADP
admet-276	70	32	relevant	relevant	ADJ
admet-276	70	33	animal	animal	NOUN
admet-276	70	34	species	specie	NOUN
admet-276	70	35	.	.	PUNCT
admet-276	71	1	it	it	PRON
admet-276	71	2	should	should	AUX
admet-276	71	3	be	be	AUX
admet-276	71	4	noted	note	VERB
admet-276	71	5	that	that	SCONJ
admet-276	71	6	the	the	DET
admet-276	71	7	selected	select	VERB
admet-276	71	8	species	specie	NOUN
admet-276	71	9	for	for	ADP
admet-276	71	10	in	in	ADP
admet-276	71	11	vivo	vivo	ADJ
admet-276	71	12	pk	pk	NOUN
admet-276	71	13	and	and	CCONJ
admet-276	71	14	toxicity	toxicity	NOUN
admet-276	71	15	evaluations	evaluation	NOUN
admet-276	71	16	should	should	AUX
admet-276	71	17	preferably	preferably	ADV
admet-276	71	18	have	have	VERB
admet-276	71	19	cross	cross	NOUN
admet-276	71	20	-	-	NOUN
admet-276	71	21	reactivity	reactivity	NOUN
admet-276	71	22	with	with	ADP
admet-276	71	23	human	human	NOUN
admet-276	71	24	.	.	PUNCT
admet-276	72	1	another	another	DET
admet-276	72	2	important	important	ADJ
admet-276	72	3	aspect	aspect	NOUN
admet-276	72	4	to	to	PART
admet-276	72	5	consider	consider	VERB
admet-276	72	6	is	be	AUX
admet-276	72	7	immunogenicity	immunogenicity	NOUN
admet-276	72	8	for	for	ADP
admet-276	72	9	adme	adme	NOUN
admet-276	72	10	testing	testing	NOUN
admet-276	72	11	of	of	ADP
admet-276	72	12	mabs	mab	NOUN
admet-276	72	13	as	as	ADV
admet-276	72	14	well	well	ADV
admet-276	72	15	as	as	ADP
admet-276	72	16	adcs	adcs	ADJ
admet-276	72	17	,	,	PUNCT
admet-276	72	18	which	which	PRON
admet-276	72	19	is	be	AUX
admet-276	72	20	a	a	DET
admet-276	72	21	key	key	ADJ
admet-276	72	22	risk	risk	NOUN
admet-276	72	23	in	in	ADP
admet-276	72	24	biologic	biologic	ADJ
admet-276	72	25	drug	drug	NOUN
admet-276	72	26	development	development	NOUN
admet-276	72	27	,	,	PUNCT
admet-276	72	28	because	because	SCONJ
admet-276	72	29	therapeutic	therapeutic	ADJ
admet-276	72	30	biotechnology	biotechnology	NOUN
admet-276	72	31	-	-	PUNCT
admet-276	72	32	driven	drive	VERB
admet-276	72	33	proteins	protein	NOUN
admet-276	72	34	must	must	AUX
admet-276	72	35	be	be	AUX
admet-276	72	36	as	as	ADV
admet-276	72	37	similar	similar	ADJ
admet-276	72	38	as	as	ADP
admet-276	72	39	possible	possible	ADJ
admet-276	72	40	in	in	ADP
admet-276	72	41	primary	primary	ADJ
admet-276	72	42	,	,	PUNCT
admet-276	72	43	secondary	secondary	ADJ
admet-276	72	44	,	,	PUNCT
admet-276	72	45	and	and	CCONJ
admet-276	72	46	tertiary	tertiary	ADJ
admet-276	72	47	structures	structure	NOUN
admet-276	72	48	to	to	ADP
admet-276	72	49	its	its	PRON
admet-276	72	50	human	human	ADJ
admet-276	72	51	homologues	homologue	NOUN
admet-276	72	52	in	in	ADP
admet-276	72	53	order	order	NOUN
admet-276	72	54	to	to	PART
admet-276	72	55	avoid	avoid	VERB
admet-276	72	56	immunogenicity	immunogenicity	NOUN
admet-276	72	57	[	[	X
admet-276	72	58	2,40	2,40	NUM
admet-276	72	59	]	]	X
admet-276	72	60	.	.	PUNCT
admet-276	73	1	in	in	ADP
admet-276	73	2	general	general	ADJ
admet-276	73	3	,	,	PUNCT
admet-276	73	4	the	the	DET
admet-276	73	5	immunogenicity	immunogenicity	NOUN
admet-276	73	6	,	,	PUNCT
admet-276	73	7	specifically	specifically	ADV
admet-276	73	8	formation	formation	NOUN
admet-276	73	9	of	of	ADP
admet-276	73	10	anti	anti	ADJ
admet-276	73	11	-	-	ADJ
admet-276	73	12	drug	drug	ADJ
admet-276	73	13	antibody	antibody	NOUN
admet-276	73	14	(	(	PUNCT
admet-276	73	15	ada	ada	PROPN
admet-276	73	16	)	)	PUNCT
admet-276	73	17	,	,	PUNCT
admet-276	73	18	is	be	AUX
admet-276	73	19	one	one	NUM
admet-276	73	20	of	of	ADP
admet-276	73	21	the	the	DET
admet-276	73	22	major	major	ADJ
admet-276	73	23	complicating	complicate	VERB
admet-276	73	24	issues	issue	NOUN
admet-276	73	25	in	in	ADP
admet-276	73	26	nonclinical	nonclinical	ADJ
admet-276	73	27	and	and	CCONJ
admet-276	73	28	clinical	clinical	ADJ
admet-276	73	29	programs	program	NOUN
admet-276	73	30	for	for	ADP
admet-276	73	31	therapeutic	therapeutic	ADJ
admet-276	73	32	proteins	protein	NOUN
admet-276	73	33	,	,	PUNCT
admet-276	73	34	which	which	PRON
admet-276	73	35	is	be	AUX
admet-276	73	36	a	a	DET
admet-276	73	37	regulatory	regulatory	ADJ
admet-276	73	38	requirement	requirement	NOUN
admet-276	73	39	as	as	ADP
admet-276	73	40	part	part	NOUN
admet-276	73	41	of	of	ADP
admet-276	73	42	the	the	DET
admet-276	73	43	safety	safety	NOUN
admet-276	73	44	assessment	assessment	NOUN
admet-276	73	45	of	of	ADP
admet-276	73	46	biotherapeutic	biotherapeutic	ADJ
admet-276	73	47	submission	submission	NOUN
admet-276	73	48	[	[	X
admet-276	73	49	34,38,41	34,38,41	NUM
admet-276	73	50	]	]	X
admet-276	73	51	.	.	PUNCT
admet-276	74	1	the	the	DET
admet-276	74	2	ada	ada	PROPN
admet-276	74	3	production	production	NOUN
admet-276	74	4	due	due	ADP
admet-276	74	5	to	to	ADP
admet-276	74	6	the	the	DET
admet-276	74	7	continuous	continuous	ADJ
admet-276	74	8	administration	administration	NOUN
admet-276	74	9	of	of	ADP
admet-276	74	10	mabs	mab	NOUN
admet-276	74	11	may	may	AUX
admet-276	74	12	affect	affect	VERB
admet-276	74	13	the	the	DET
admet-276	74	14	pk	pk	NOUN
admet-276	74	15	and/or	and/or	CCONJ
admet-276	74	16	the	the	DET
admet-276	74	17	pd	pd	PROPN
admet-276	74	18	of	of	ADP
admet-276	74	19	mabs	mab	NOUN
admet-276	74	20	after	after	SCONJ
admet-276	74	21	they	they	PRON
admet-276	74	22	are	be	AUX
admet-276	74	23	administrated	administrate	VERB
admet-276	74	24	to	to	ADP
admet-276	74	25	patients	patient	NOUN
admet-276	74	26	[	[	X
admet-276	74	27	40	40	NUM
admet-276	74	28	]	]	PUNCT
admet-276	74	29	.	.	PUNCT
admet-276	75	1	when	when	SCONJ
admet-276	75	2	an	an	DET
admet-276	75	3	immunogenic	immunogenic	ADJ
admet-276	75	4	reaction	reaction	NOUN
admet-276	75	5	mediated	mediate	VERB
admet-276	75	6	by	by	ADP
admet-276	75	7	adas	adas	PROPN
admet-276	75	8	takes	take	VERB
admet-276	75	9	place	place	NOUN
admet-276	75	10	,	,	PUNCT
admet-276	75	11	it	it	PRON
admet-276	75	12	can	can	AUX
admet-276	75	13	increase	increase	VERB
admet-276	75	14	blood	blood	NOUN
admet-276	75	15	clearance	clearance	NOUN
admet-276	75	16	and	and	CCONJ
admet-276	75	17	decreases	decrease	VERB
admet-276	75	18	exposure	exposure	NOUN
admet-276	75	19	(	(	PUNCT
admet-276	75	20	often	often	ADV
admet-276	75	21	relatively	relatively	ADV
admet-276	75	22	shorter	short	ADJ
admet-276	75	23	half	half	ADJ
admet-276	75	24	-	-	PUNCT
admet-276	75	25	life	life	NOUN
admet-276	75	26	observed	observe	VERB
admet-276	75	27	)	)	PUNCT
admet-276	75	28	,	,	PUNCT
admet-276	75	29	thereby	thereby	ADV
admet-276	75	30	reducing	reduce	VERB
admet-276	75	31	its	its	PRON
admet-276	75	32	efficacy	efficacy	NOUN
admet-276	75	33	and	and	CCONJ
admet-276	75	34	likely	likely	ADV
admet-276	75	35	in	in	ADP
admet-276	75	36	vitro	vitro	X
admet-276	75	37	potency	potency	NOUN
admet-276	75	38	/	/	SYM
admet-276	75	39	binding	bind	VERB
admet-276	75	40	solubility	solubility	NOUN
admet-276	75	41	metabolic	metabolic	NOUN
admet-276	75	42	stability	stability	NOUN
admet-276	75	43	permeability	permeability	NOUN
admet-276	75	44	/	/	SYM
admet-276	75	45	transporter	transporter	NOUN
admet-276	75	46	logd7.4	logd7.4	PUNCT
admet-276	75	47	in	in	ADP
admet-276	75	48	vivo	vivo	NOUN
admet-276	75	49	pk	pk	NOUN
admet-276	75	50	ppb	ppb	NOUN
admet-276	75	51	cyp	cyp	ADJ
admet-276	75	52	inhibition	inhibition	NOUN
admet-276	75	53	metabolite	metabolite	NOUN
admet-276	75	54	prof	prof	NOUN
admet-276	75	55	iling	iling	NOUN
admet-276	75	56	and	and	CCONJ
admet-276	75	57	i	i	PROPN
admet-276	75	58	d	d	PROPN
admet-276	75	59	pk	pk	PROPN
admet-276	75	60	/	/	SYM
admet-276	75	61	pd	pd	NOUN
admet-276	75	62	toxicity	toxicity	NOUN
admet-276	75	63	and	and	CCONJ
admet-276	75	64	safety	safety	NOUN
admet-276	75	65	margin	margin	NOUN
admet-276	75	66	small	small	ADJ
admet-276	75	67	molecule	molecule	NOUN
admet-276	75	68	antibody	antibody	NOUN
admet-276	75	69	adc	adc	PROPN
admet-276	75	70	excretion	excretion	NOUN
admet-276	75	71	/	/	SYM
admet-276	75	72	mass	mass	NOUN
admet-276	75	73	balance	balance	NOUN
admet-276	75	74	preclinical	preclinical	ADJ
admet-276	75	75	candidate	candidate	NOUN
admet-276	75	76	(	(	PUNCT
admet-276	75	77	pcc	pcc	NOUN
admet-276	75	78	)	)	PUNCT
admet-276	75	79	in	in	ADP
admet-276	75	80	vivo	vivo	ADJ
admet-276	75	81	pk	pk	NOUN
admet-276	75	82	&	&	CCONJ
admet-276	75	83	immunogenicity	immunogenicity	PROPN
admet-276	75	84	pk	pk	PROPN
admet-276	75	85	/	/	SYM
admet-276	75	86	pd	pd	PROPN
admet-276	75	87	pk	pk	PROPN
admet-276	75	88	/	/	SYM
admet-276	75	89	pd	pd	NOUN
admet-276	75	90	toxicity	toxicity	NOUN
admet-276	75	91	and	and	CCONJ
admet-276	75	92	safety	safety	NOUN
admet-276	75	93	margin	margin	NOUN
admet-276	75	94	toxicity	toxicity	NOUN
admet-276	75	95	(	(	PUNCT
admet-276	75	96	adc	adc	PROPN
admet-276	75	97	,	,	PUNCT
admet-276	75	98	toxin	toxin	NOUN
admet-276	75	99	)	)	PUNCT
admet-276	75	100	dar	dar	NOUN
admet-276	75	101	distribution	distribution	NOUN
admet-276	75	102	(	(	PUNCT
admet-276	75	103	in	in	ADP
admet-276	75	104	vitro	vitro	X
admet-276	75	105	)	)	PUNCT
admet-276	75	106	tissue	tissue	NOUN
admet-276	75	107	distribution	distribution	NOUN
admet-276	75	108	/	/	SYM
admet-276	75	109	mass	mass	NOUN
admet-276	75	110	balance	balance	NOUN
admet-276	75	111	metabolites	metabolite	NOUN
admet-276	75	112	/	/	SYM
admet-276	75	113	catabolites	catabolite	VERB
admet-276	75	114	stability	stability	NOUN
admet-276	75	115	of	of	ADP
admet-276	75	116	linkers	linker	NOUN
admet-276	75	117	(	(	PUNCT
admet-276	75	118	plasma	plasma	NOUN
admet-276	75	119	)	)	PUNCT
admet-276	75	120	aggregation	aggregation	NOUN
admet-276	75	121	&	&	CCONJ
admet-276	75	122	f	f	PROPN
admet-276	75	123	ragmentation	ragmentation	PROPN
admet-276	75	124	solubility	solubility	NOUN
admet-276	75	125	primary	primary	ADJ
admet-276	75	126	structure	structure	NOUN
admet-276	75	127	&	&	CCONJ
admet-276	75	128	sequence	sequence	NOUN
admet-276	75	129	oxidation	oxidation	NOUN
admet-276	75	130	and	and	CCONJ
admet-276	75	131	deamidation	deamidation	NOUN
admet-276	75	132	glycan	glycan	PROPN
admet-276	75	133	prof	prof	PROPN
admet-276	75	134	ile	ile	PROPN
admet-276	75	135	&	&	CCONJ
admet-276	75	136	variants	variants	PROPN
admet-276	75	137	disulf	disulf	VERB
admet-276	75	138	ide	ide	ADJ
admet-276	75	139	bonds	bond	NOUN
admet-276	75	140	analysis	analysis	NOUN
admet-276	75	141	peptide	peptide	ADJ
admet-276	75	142	mapping	mapping	NOUN
admet-276	75	143	analysis	analysis	NOUN
admet-276	75	144	antibody	antibody	NOUN
admet-276	75	145	formulation	formulation	NOUN
admet-276	75	146	stability	stability	NOUN
admet-276	75	147	post	post	ADJ
admet-276	75	148	-	-	ADJ
admet-276	75	149	translational	translational	ADJ
admet-276	75	150	modif	modif	ADJ
admet-276	75	151	ications	ication	NOUN
admet-276	75	152	analysis	analysis	VERB
admet-276	75	153	free	free	ADJ
admet-276	75	154	toxin	toxin	NOUN
admet-276	75	155	,	,	PUNCT
admet-276	75	156	ddi	ddi	PROPN
admet-276	75	157	charge	charge	NOUN
admet-276	75	158	variants	variant	NOUN
admet-276	75	159	aggregation	aggregation	NOUN
admet-276	75	160	&	&	CCONJ
admet-276	75	161	f	f	PROPN
admet-276	75	162	ragmentation	ragmentation	PROPN
admet-276	75	163	charge	charge	NOUN
admet-276	75	164	variants	variant	NOUN
admet-276	75	165	peptide	peptide	VERB
admet-276	75	166	mapping	mapping	NOUN
admet-276	75	167	analysis	analysis	NOUN
admet-276	75	168	conjugate	conjugate	ADJ
admet-276	75	169	site	site	NOUN
admet-276	75	170	analysis	analysis	NOUN
admet-276	75	171	in	in	ADP
admet-276	75	172	vivo	vivo	ADJ
admet-276	75	173	pk	pk	NOUN
admet-276	75	174	&	&	CCONJ
admet-276	75	175	immunogenicity	immunogenicity	NOUN
admet-276	75	176	dar	dar	NOUN
admet-276	75	177	distribution	distribution	NOUN
admet-276	75	178	(	(	PUNCT
admet-276	75	179	in	in	ADP
admet-276	75	180	vivo	vivo	NOUN
admet-276	75	181	)	)	PUNCT
admet-276	75	182	plasma	plasma	NOUN
admet-276	75	183	stability	stability	NOUN
admet-276	75	184	ddi	ddi	PROPN
admet-276	75	185	evaluation	evaluation	NOUN
admet-276	75	186	hong	hong	PROPN
admet-276	75	187	wan	wan	PROPN
admet-276	75	188	admet	admet	PROPN
admet-276	75	189	&	&	CCONJ
admet-276	75	190	dmpk	dmpk	PROPN
admet-276	75	191	4(1	4(1	NOUN
admet-276	75	192	)	)	PUNCT
admet-276	75	193	(	(	PUNCT
admet-276	75	194	2016	2016	NUM
admet-276	75	195	)	)	PUNCT
admet-276	75	196	1	1	NUM
admet-276	75	197	-	-	SYM
admet-276	75	198	22	22	NUM
admet-276	75	199	6	6	NUM
admet-276	75	200	hampering	hamper	VERB
admet-276	75	201	its	its	PRON
admet-276	75	202	clinical	clinical	ADJ
admet-276	75	203	application	application	NOUN
admet-276	75	204	in	in	ADP
admet-276	75	205	some	some	DET
admet-276	75	206	instances	instance	NOUN
admet-276	75	207	.	.	PUNCT
admet-276	76	1	although	although	SCONJ
admet-276	76	2	factors	factor	NOUN
admet-276	76	3	that	that	PRON
admet-276	76	4	affect	affect	VERB
admet-276	76	5	ada	ada	PROPN
admet-276	76	6	are	be	AUX
admet-276	76	7	complex	complex	ADJ
admet-276	76	8	and	and	CCONJ
admet-276	76	9	the	the	DET
admet-276	76	10	relationship	relationship	NOUN
admet-276	76	11	of	of	ADP
admet-276	76	12	bioanalytical	bioanalytical	ADJ
admet-276	76	13	measures	measure	NOUN
admet-276	76	14	,	,	PUNCT
admet-276	76	15	for	for	ADP
admet-276	76	16	example	example	NOUN
admet-276	76	17	,	,	PUNCT
admet-276	76	18	incidence	incidence	NOUN
admet-276	76	19	and	and	CCONJ
admet-276	76	20	magnitude	magnitude	NOUN
admet-276	76	21	of	of	ADP
admet-276	76	22	ada	ada	PROPN
admet-276	76	23	responses	response	NOUN
admet-276	76	24	to	to	ADP
admet-276	76	25	clinical	clinical	ADJ
admet-276	76	26	efficacy	efficacy	NOUN
admet-276	76	27	and	and	CCONJ
admet-276	76	28	safety	safety	NOUN
admet-276	76	29	are	be	AUX
admet-276	76	30	uncertain	uncertain	ADJ
admet-276	76	31	,	,	PUNCT
admet-276	76	32	the	the	DET
admet-276	76	33	ada	ada	PROPN
admet-276	76	34	incidence	incidence	NOUN
admet-276	76	35	and	and	CCONJ
admet-276	76	36	magnitude	magnitude	NOUN
admet-276	76	37	should	should	AUX
admet-276	76	38	always	always	ADV
admet-276	76	39	be	be	AUX
admet-276	76	40	assessed	assess	VERB
admet-276	76	41	relative	relative	ADJ
admet-276	76	42	to	to	ADP
admet-276	76	43	capacity	capacity	NOUN
admet-276	76	44	of	of	ADP
admet-276	76	45	adas	adas	PROPN
admet-276	76	46	to	to	PART
admet-276	76	47	neutralize	neutralize	VERB
admet-276	76	48	the	the	DET
admet-276	76	49	relevant	relevant	ADJ
admet-276	76	50	biological	biological	ADJ
admet-276	76	51	activity	activity	NOUN
admet-276	76	52	of	of	ADP
admet-276	76	53	the	the	DET
admet-276	76	54	therapeutic	therapeutic	ADJ
admet-276	76	55	mab	mab	NOUN
admet-276	76	56	,	,	PUNCT
admet-276	76	57	in	in	ADP
admet-276	76	58	addition	addition	NOUN
admet-276	76	59	to	to	ADP
admet-276	76	60	impact	impact	NOUN
admet-276	76	61	on	on	ADP
admet-276	76	62	drug	drug	NOUN
admet-276	76	63	levels	level	NOUN
admet-276	76	64	and	and	CCONJ
admet-276	76	65	clinical	clinical	ADJ
admet-276	76	66	measures	measure	NOUN
admet-276	76	67	of	of	ADP
admet-276	76	68	efficacy	efficacy	NOUN
admet-276	76	69	and	and	CCONJ
admet-276	76	70	safety	safety	NOUN
admet-276	77	1	[	[	X
admet-276	77	2	42	42	NUM
admet-276	77	3	]	]	PUNCT
admet-276	77	4	.	.	PUNCT
admet-276	78	1	in	in	ADP
admet-276	78	2	principle	principle	NOUN
admet-276	78	3	,	,	PUNCT
admet-276	78	4	it	it	PRON
admet-276	78	5	would	would	AUX
admet-276	78	6	be	be	AUX
admet-276	78	7	acceptable	acceptable	ADJ
admet-276	78	8	for	for	SCONJ
admet-276	78	9	the	the	DET
admet-276	78	10	biologic	biologic	NOUN
admet-276	78	11	product	product	NOUN
admet-276	78	12	to	to	PART
admet-276	78	13	be	be	AUX
admet-276	78	14	less	less	ADV
admet-276	78	15	immunogenic	immunogenic	ADJ
admet-276	78	16	than	than	ADP
admet-276	78	17	the	the	DET
admet-276	78	18	reference	reference	NOUN
admet-276	78	19	product	product	NOUN
admet-276	78	20	,	,	PUNCT
admet-276	78	21	provided	provide	VERB
admet-276	78	22	that	that	SCONJ
admet-276	78	23	this	this	PRON
admet-276	78	24	did	do	AUX
admet-276	78	25	not	not	PART
admet-276	78	26	modify	modify	VERB
admet-276	78	27	the	the	DET
admet-276	78	28	efficacy	efficacy	NOUN
admet-276	78	29	of	of	ADP
admet-276	78	30	the	the	DET
admet-276	78	31	product	product	NOUN
admet-276	78	32	or	or	CCONJ
admet-276	78	33	increase	increase	VERB
admet-276	78	34	the	the	DET
admet-276	78	35	incidence	incidence	NOUN
admet-276	78	36	or	or	CCONJ
admet-276	78	37	severity	severity	NOUN
admet-276	78	38	of	of	ADP
admet-276	78	39	adverse	adverse	ADJ
admet-276	78	40	reactions	reaction	NOUN
admet-276	78	41	,	,	PUNCT
admet-276	78	42	although	although	SCONJ
admet-276	78	43	the	the	DET
admet-276	78	44	magnitude	magnitude	NOUN
admet-276	78	45	of	of	ADP
admet-276	78	46	ada	ada	PROPN
admet-276	78	47	acceptance	acceptance	NOUN
admet-276	78	48	is	be	AUX
admet-276	78	49	not	not	PART
admet-276	78	50	defined	define	VERB
admet-276	78	51	by	by	ADP
admet-276	78	52	regulators	regulator	NOUN
admet-276	79	1	[	[	X
admet-276	79	2	42	42	NUM
admet-276	79	3	]	]	PUNCT
admet-276	79	4	.	.	PUNCT
admet-276	80	1	one	one	PRON
admet-276	80	2	should	should	AUX
admet-276	80	3	also	also	ADV
admet-276	80	4	bear	bear	VERB
admet-276	80	5	in	in	ADP
admet-276	80	6	mind	mind	NOUN
admet-276	80	7	that	that	SCONJ
admet-276	80	8	the	the	DET
admet-276	80	9	bioanalytical	bioanalytical	ADJ
admet-276	80	10	methods	method	NOUN
admet-276	80	11	used	use	VERB
admet-276	80	12	to	to	PART
admet-276	80	13	monitor	monitor	VERB
admet-276	80	14	immunogenicity	immunogenicity	NOUN
admet-276	80	15	are	be	AUX
admet-276	80	16	subject	subject	ADJ
admet-276	80	17	to	to	ADP
admet-276	80	18	various	various	ADJ
admet-276	80	19	biases	bias	NOUN
admet-276	80	20	when	when	SCONJ
admet-276	80	21	interpreting	interpret	VERB
admet-276	80	22	ada	ada	PROPN
admet-276	80	23	data	data	PROPN
admet-276	80	24	and	and	CCONJ
admet-276	80	25	assessing	assess	VERB
admet-276	80	26	immunogenicity	immunogenicity	NOUN
admet-276	80	27	.	.	PUNCT
admet-276	81	1	in	in	ADP
admet-276	81	2	practice	practice	NOUN
admet-276	81	3	,	,	PUNCT
admet-276	81	4	a	a	DET
admet-276	81	5	comparison	comparison	NOUN
admet-276	81	6	of	of	ADP
admet-276	81	7	single	single	ADJ
admet-276	81	8	dosing	dosing	ADJ
admet-276	81	9	pk	pk	NOUN
admet-276	81	10	and	and	CCONJ
admet-276	81	11	multiple	multiple	ADJ
admet-276	81	12	dosing	dose	VERB
admet-276	81	13	pk	pk	NOUN
admet-276	81	14	with	with	ADP
admet-276	81	15	monitoring	monitor	VERB
admet-276	81	16	ada	ada	PROPN
admet-276	81	17	production	production	NOUN
admet-276	81	18	over	over	ADP
admet-276	81	19	time	time	NOUN
admet-276	81	20	is	be	AUX
admet-276	81	21	valuable	valuable	ADJ
admet-276	81	22	for	for	ADP
admet-276	81	23	a	a	DET
admet-276	81	24	better	well	ADJ
admet-276	81	25	understanding	understanding	NOUN
admet-276	81	26	of	of	ADP
admet-276	81	27	the	the	DET
admet-276	81	28	pk	pk	PROPN
admet-276	81	29	/	/	SYM
admet-276	81	30	pd	pd	NOUN
admet-276	81	31	relation	relation	NOUN
admet-276	81	32	of	of	ADP
admet-276	81	33	mabs	mab	NOUN
admet-276	81	34	as	as	ADV
admet-276	81	35	well	well	ADV
admet-276	81	36	as	as	ADP
admet-276	81	37	the	the	DET
admet-276	81	38	part	part	NOUN
admet-276	81	39	of	of	ADP
admet-276	81	40	mab	mab	NOUN
admet-276	81	41	quality	quality	NOUN
admet-276	81	42	evaluation	evaluation	NOUN
admet-276	81	43	.	.	PUNCT
admet-276	82	1	to	to	ADP
admet-276	82	2	the	the	DET
admet-276	82	3	best	good	ADJ
admet-276	82	4	of	of	ADP
admet-276	82	5	our	our	PRON
admet-276	82	6	knowledge	knowledge	NOUN
admet-276	82	7	,	,	PUNCT
admet-276	82	8	once	once	SCONJ
admet-276	82	9	the	the	DET
admet-276	82	10	ada	ada	PROPN
admet-276	82	11	occurs	occur	VERB
admet-276	82	12	over	over	ADP
admet-276	82	13	the	the	DET
admet-276	82	14	time	time	NOUN
admet-276	82	15	,	,	PUNCT
admet-276	82	16	the	the	DET
admet-276	82	17	plasma	plasma	NOUN
admet-276	82	18	concentration	concentration	NOUN
admet-276	82	19	at	at	ADP
admet-276	82	20	certain	certain	ADJ
admet-276	82	21	time	time	NOUN
admet-276	82	22	point	point	NOUN
admet-276	82	23	can	can	AUX
admet-276	82	24	drop	drop	VERB
admet-276	82	25	dramatically	dramatically	ADV
admet-276	82	26	.	.	PUNCT
admet-276	83	1	consequently	consequently	ADV
admet-276	83	2	,	,	PUNCT
admet-276	83	3	caution	caution	NOUN
admet-276	83	4	has	have	VERB
admet-276	83	5	to	to	PART
admet-276	83	6	be	be	AUX
admet-276	83	7	taken	take	VERB
admet-276	83	8	to	to	PART
admet-276	83	9	evaluate	evaluate	VERB
admet-276	83	10	the	the	DET
admet-276	83	11	pk	pk	NOUN
admet-276	83	12	parameters	parameter	NOUN
admet-276	83	13	in	in	ADP
admet-276	83	14	particular	particular	ADJ
admet-276	83	15	calculate	calculate	VERB
admet-276	83	16	the	the	DET
admet-276	83	17	half	half	ADJ
admet-276	83	18	-	-	PUNCT
admet-276	83	19	life	life	NOUN
admet-276	83	20	of	of	ADP
admet-276	83	21	mab	mab	NOUN
admet-276	83	22	with	with	ADP
admet-276	83	23	different	different	ADJ
admet-276	83	24	compartmental	compartmental	ADJ
admet-276	83	25	models	model	NOUN
admet-276	83	26	to	to	PART
admet-276	83	27	be	be	AUX
admet-276	83	28	in	in	ADP
admet-276	83	29	line	line	NOUN
admet-276	83	30	with	with	ADP
admet-276	83	31	its	its	PRON
admet-276	83	32	corresponding	correspond	VERB
admet-276	83	33	plasma	plasma	NOUN
admet-276	83	34	concentrations	concentration	NOUN
admet-276	83	35	for	for	ADP
admet-276	83	36	the	the	DET
admet-276	83	37	correct	correct	ADJ
admet-276	83	38	interpretation	interpretation	NOUN
admet-276	83	39	of	of	ADP
admet-276	83	40	pd	pd	PROPN
admet-276	83	41	effect	effect	NOUN
admet-276	83	42	or	or	CCONJ
admet-276	83	43	its	its	PRON
admet-276	83	44	pk	pk	NOUN
admet-276	83	45	/	/	SYM
admet-276	83	46	pd	pd	PROPN
admet-276	83	47	relationship	relationship	NOUN
admet-276	83	48	.	.	PUNCT
admet-276	84	1	additionally	additionally	ADV
admet-276	84	2	,	,	PUNCT
admet-276	84	3	mathematical	mathematical	ADJ
admet-276	84	4	modeling	modeling	NOUN
admet-276	84	5	of	of	ADP
admet-276	84	6	ada	ada	PROPN
admet-276	84	7	response	response	NOUN
admet-276	84	8	against	against	ADP
admet-276	84	9	mabs	mab	NOUN
admet-276	84	10	and	and	CCONJ
admet-276	84	11	its	its	PRON
admet-276	84	12	impact	impact	NOUN
admet-276	84	13	on	on	ADP
admet-276	84	14	mab	mab	PROPN
admet-276	84	15	pk	pk	PROPN
admet-276	84	16	/	/	SYM
admet-276	84	17	pd	pd	PROPN
admet-276	84	18	has	have	AUX
admet-276	84	19	been	be	AUX
admet-276	84	20	reviewed	review	VERB
admet-276	84	21	recently	recently	ADV
admet-276	84	22	[	[	X
admet-276	84	23	40	40	NUM
admet-276	84	24	]	]	PUNCT
admet-276	84	25	.	.	PUNCT
admet-276	85	1	currently	currently	ADV
admet-276	85	2	,	,	PUNCT
admet-276	85	3	ligand	ligand	ADJ
admet-276	85	4	binding	bind	VERB
admet-276	85	5	assay	assay	NOUN
admet-276	85	6	(	(	PUNCT
admet-276	85	7	lba	lba	PROPN
admet-276	85	8	)	)	PUNCT
admet-276	85	9	such	such	ADJ
admet-276	85	10	as	as	ADP
admet-276	85	11	enzyme	enzyme	NOUN
admet-276	85	12	-	-	PUNCT
admet-276	85	13	linked	link	VERB
admet-276	85	14	immunesorbent	immunesorbent	NOUN
admet-276	85	15	assays	assay	NOUN
admet-276	85	16	(	(	PUNCT
admet-276	85	17	elisa	elisa	NOUN
admet-276	85	18	)	)	PUNCT
admet-276	85	19	are	be	AUX
admet-276	85	20	generally	generally	ADV
admet-276	85	21	regarded	regard	VERB
admet-276	85	22	as	as	ADP
admet-276	85	23	the	the	DET
admet-276	85	24	gold	gold	ADJ
admet-276	85	25	standard	standard	ADJ
admet-276	85	26	methods	method	NOUN
admet-276	85	27	for	for	ADP
admet-276	85	28	bioanalysis	bioanalysis	NOUN
admet-276	85	29	of	of	ADP
admet-276	85	30	lms	lm	NOUN
admet-276	85	31	with	with	ADP
admet-276	85	32	sufficient	sufficient	ADJ
admet-276	85	33	sensitivity	sensitivity	NOUN
admet-276	85	34	and	and	CCONJ
admet-276	85	35	specificity	specificity	NOUN
admet-276	85	36	.	.	PUNCT
admet-276	86	1	of	of	ADP
admet-276	86	2	them	they	PRON
admet-276	86	3	,	,	PUNCT
admet-276	86	4	the	the	DET
admet-276	86	5	sandwich	sandwich	NOUN
admet-276	86	6	and	and	CCONJ
admet-276	86	7	competition	competition	NOUN
admet-276	86	8	enzyme	enzyme	NOUN
admet-276	86	9	immunoassay	immunoassay	ADJ
admet-276	86	10	technique	technique	NOUN
admet-276	86	11	are	be	AUX
admet-276	86	12	more	more	ADV
admet-276	86	13	widely	widely	ADV
admet-276	86	14	utilized	utilize	VERB
admet-276	86	15	for	for	ADP
admet-276	86	16	detection	detection	NOUN
admet-276	86	17	and	and	CCONJ
admet-276	86	18	quantification	quantification	NOUN
admet-276	86	19	of	of	ADP
admet-276	86	20	antibodies	antibody	NOUN
admet-276	86	21	[	[	X
admet-276	86	22	43	43	NUM
admet-276	86	23	-	-	SYM
admet-276	86	24	45	45	NUM
admet-276	86	25	]	]	PUNCT
admet-276	86	26	.	.	PUNCT
admet-276	87	1	typically	typically	ADV
admet-276	87	2	,	,	PUNCT
admet-276	87	3	various	various	ADJ
admet-276	87	4	coat	coat	NOUN
admet-276	87	5	capture	capture	VERB
admet-276	87	6	reagents	reagent	NOUN
admet-276	87	7	,	,	PUNCT
admet-276	87	8	conjugate	conjugate	ADJ
admet-276	87	9	reagents	reagent	NOUN
admet-276	87	10	(	(	PUNCT
admet-276	87	11	e.g.	e.g.	ADV
admet-276	87	12	horseradish	horseradish	ADJ
admet-276	87	13	peroxidase	peroxidase	NOUN
admet-276	87	14	,	,	PUNCT
admet-276	87	15	hrp	hrp	PROPN
admet-276	87	16	)	)	PUNCT
admet-276	87	17	,	,	PUNCT
admet-276	87	18	peroxidase	peroxidase	NOUN
admet-276	87	19	substrates	substrate	NOUN
admet-276	87	20	(	(	PUNCT
admet-276	87	21	e.g.	e.g.	ADV
admet-276	87	22	tmb	tmb	NOUN
admet-276	87	23	,	,	PUNCT
admet-276	87	24	stabilized	stabilize	VERB
admet-276	87	25	hydrogen	hydrogen	NOUN
admet-276	87	26	peroxide	peroxide	NOUN
admet-276	87	27	/	/	SYM
admet-276	87	28	tmb	tmb	NOUN
admet-276	87	29	)	)	PUNCT
admet-276	87	30	and	and	CCONJ
admet-276	87	31	stop	stop	VERB
admet-276	87	32	solution	solution	NOUN
admet-276	87	33	(	(	PUNCT
admet-276	87	34	e.g.	e.g.	ADV
admet-276	87	35	sulfuric	sulfuric	NOUN
admet-276	87	36	acid	acid	NOUN
admet-276	87	37	)	)	PUNCT
admet-276	87	38	are	be	AUX
admet-276	87	39	employed	employ	VERB
admet-276	87	40	case	case	NOUN
admet-276	87	41	by	by	ADP
admet-276	87	42	case	case	NOUN
admet-276	87	43	.	.	PUNCT
admet-276	88	1	to	to	ADP
admet-276	88	2	date	date	NOUN
admet-276	88	3	,	,	PUNCT
admet-276	88	4	the	the	DET
admet-276	88	5	standard	standard	ADJ
admet-276	88	6	elisa	elisa	NOUN
admet-276	88	7	platform	platform	NOUN
admet-276	88	8	has	have	AUX
admet-276	88	9	considerably	considerably	ADV
admet-276	88	10	been	be	AUX
admet-276	88	11	improved	improve	VERB
admet-276	88	12	upon	upon	SCONJ
admet-276	88	13	over	over	ADP
admet-276	88	14	the	the	DET
admet-276	88	15	years	year	NOUN
admet-276	88	16	,	,	PUNCT
admet-276	88	17	involving	involve	VERB
admet-276	88	18	automation	automation	NOUN
admet-276	88	19	and	and	CCONJ
admet-276	88	20	improved	improved	ADJ
admet-276	88	21	detection	detection	NOUN
admet-276	88	22	methodologies	methodology	NOUN
admet-276	88	23	,	,	PUNCT
admet-276	88	24	and	and	CCONJ
admet-276	88	25	new	new	ADJ
admet-276	88	26	applications	application	NOUN
admet-276	88	27	of	of	ADP
admet-276	88	28	this	this	DET
admet-276	88	29	technique	technique	NOUN
admet-276	88	30	is	be	AUX
admet-276	88	31	further	far	ADV
admet-276	88	32	discussed	discuss	VERB
admet-276	88	33	in	in	ADP
admet-276	88	34	next	next	ADJ
admet-276	88	35	bioanalysis	bioanalysis	NOUN
admet-276	88	36	section	section	NOUN
admet-276	88	37	.	.	PUNCT
admet-276	89	1	2.2	2.2	NUM
admet-276	89	2	.	.	PUNCT
admet-276	90	1	adme	adme	NOUN
admet-276	90	2	testing	testing	NOUN
admet-276	90	3	of	of	ADP
admet-276	90	4	adcs	adcs	PROPN
admet-276	90	5	adcs	adc	NOUN
admet-276	90	6	are	be	AUX
admet-276	90	7	mabs	mab	NOUN
admet-276	90	8	with	with	ADP
admet-276	90	9	covalently	covalently	ADV
admet-276	90	10	bound	bind	VERB
admet-276	90	11	cytotoxic	cytotoxic	ADJ
admet-276	90	12	drugs	drug	NOUN
admet-276	90	13	via	via	ADP
admet-276	90	14	a	a	DET
admet-276	90	15	linker	linker	NOUN
admet-276	90	16	,	,	PUNCT
admet-276	90	17	which	which	PRON
admet-276	90	18	are	be	AUX
admet-276	90	19	designed	design	VERB
admet-276	90	20	to	to	PART
admet-276	90	21	target	target	VERB
admet-276	90	22	tumor	tumor	NOUN
admet-276	90	23	antigens	antigen	NOUN
admet-276	90	24	selectively	selectively	ADV
admet-276	90	25	and	and	CCONJ
admet-276	90	26	offer	offer	VERB
admet-276	90	27	the	the	DET
admet-276	90	28	hope	hope	NOUN
admet-276	90	29	of	of	ADP
admet-276	90	30	cancer	cancer	NOUN
admet-276	90	31	treatment	treatment	NOUN
admet-276	90	32	to	to	PART
admet-276	90	33	decrease	decrease	VERB
admet-276	90	34	the	the	DET
admet-276	90	35	off	off	ADP
admet-276	90	36	-	-	PUNCT
admet-276	90	37	target	target	NOUN
admet-276	90	38	toxicity	toxicity	NOUN
admet-276	90	39	,	,	PUNCT
admet-276	90	40	thereby	thereby	ADV
admet-276	90	41	,	,	PUNCT
admet-276	90	42	improving	improve	VERB
admet-276	90	43	the	the	DET
admet-276	90	44	therapeutic	therapeutic	ADJ
admet-276	90	45	index	index	NOUN
admet-276	90	46	of	of	ADP
admet-276	90	47	the	the	DET
admet-276	90	48	cytotoxin	cytotoxin	NOUN
admet-276	91	1	[	[	X
admet-276	91	2	41,46	41,46	NOUN
admet-276	91	3	]	]	PUNCT
admet-276	91	4	.	.	PUNCT
admet-276	92	1	adcs	adcs	PROPN
admet-276	92	2	are	be	AUX
admet-276	92	3	usually	usually	ADV
admet-276	92	4	comprised	comprise	VERB
admet-276	92	5	of	of	ADP
admet-276	92	6	0	0	NUM
admet-276	92	7	to	to	PART
admet-276	92	8	8	8	NUM
admet-276	92	9	cytotoxic	cytotoxic	ADJ
admet-276	92	10	payloads	payload	NOUN
admet-276	92	11	with	with	ADP
admet-276	92	12	an	an	DET
admet-276	92	13	average	average	ADJ
admet-276	92	14	dar	dar	NOUN
admet-276	92	15	of	of	ADP
admet-276	92	16	2	2	NUM
admet-276	92	17	to	to	PART
admet-276	92	18	4	4	NUM
admet-276	92	19	per	per	ADP
admet-276	92	20	mab	mab	NOUN
admet-276	92	21	,	,	PUNCT
admet-276	92	22	which	which	PRON
admet-276	92	23	are	be	AUX
admet-276	92	24	thus	thus	ADV
admet-276	92	25	heterogeneous	heterogeneous	ADJ
admet-276	92	26	mixtures	mixture	NOUN
admet-276	92	27	of	of	ADP
admet-276	92	28	conjugates	conjugate	NOUN
admet-276	92	29	.	.	PUNCT
admet-276	93	1	given	give	VERB
admet-276	93	2	that	that	DET
admet-276	93	3	low	low	ADJ
admet-276	93	4	payloads	payload	NOUN
admet-276	93	5	reduce	reduce	VERB
admet-276	93	6	potency	potency	NOUN
admet-276	93	7	and	and	CCONJ
admet-276	93	8	high	high	ADJ
admet-276	93	9	payloads	payload	NOUN
admet-276	93	10	negatively	negatively	ADV
admet-276	93	11	impact	impact	NOUN
admet-276	93	12	pk	pk	NOUN
admet-276	93	13	,	,	PUNCT
admet-276	93	14	the	the	DET
admet-276	93	15	dars	dar	NOUN
admet-276	93	16	can	can	AUX
admet-276	93	17	have	have	VERB
admet-276	93	18	a	a	DET
admet-276	93	19	significant	significant	ADJ
admet-276	93	20	impact	impact	NOUN
admet-276	93	21	on	on	ADP
admet-276	93	22	adc	adc	PROPN
admet-276	93	23	efficacy	efficacy	NOUN
admet-276	93	24	[	[	X
admet-276	93	25	3	3	NUM
admet-276	93	26	]	]	PUNCT
admet-276	93	27	.	.	PUNCT
admet-276	94	1	structurally	structurally	ADV
admet-276	94	2	,	,	PUNCT
admet-276	94	3	the	the	DET
admet-276	94	4	antibody	antibody	NOUN
admet-276	94	5	component	component	NOUN
admet-276	94	6	of	of	ADP
admet-276	94	7	the	the	DET
admet-276	94	8	adc	adc	PROPN
admet-276	94	9	accounts	account	VERB
admet-276	94	10	for	for	ADP
admet-276	94	11	the	the	DET
admet-276	94	12	majority	majority	NOUN
admet-276	94	13	of	of	ADP
admet-276	94	14	the	the	DET
admet-276	94	15	therapeutic	therapeutic	ADJ
admet-276	94	16	agent	agent	NOUN
admet-276	94	17	(	(	PUNCT
admet-276	94	18	approximately	approximately	ADV
admet-276	94	19	98	98	NUM
admet-276	94	20	%	%	NOUN
admet-276	94	21	of	of	ADP
admet-276	94	22	total	total	ADJ
admet-276	94	23	adc	adc	NOUN
admet-276	94	24	by	by	ADP
admet-276	94	25	molecular	molecular	ADJ
admet-276	94	26	weight	weight	NOUN
admet-276	94	27	)	)	PUNCT
admet-276	94	28	.	.	PUNCT
admet-276	95	1	biologically	biologically	ADV
admet-276	95	2	,	,	PUNCT
admet-276	95	3	the	the	DET
admet-276	95	4	pk	pk	NOUN
admet-276	95	5	of	of	ADP
admet-276	95	6	adcs	adcs	PROPN
admet-276	95	7	is	be	AUX
admet-276	95	8	strongly	strongly	ADV
admet-276	95	9	influenced	influence	VERB
admet-276	95	10	by	by	ADP
admet-276	95	11	the	the	DET
admet-276	95	12	underlying	underlie	VERB
admet-276	95	13	antibody	antibody	NOUN
admet-276	95	14	backbone	backbone	NOUN
admet-276	95	15	conferring	confer	VERB
admet-276	95	16	properties	property	NOUN
admet-276	95	17	such	such	ADJ
admet-276	95	18	as	as	ADP
admet-276	95	19	target	target	NOUN
admet-276	95	20	specific	specific	ADJ
admet-276	95	21	binding	bind	VERB
admet-276	95	22	,	,	PUNCT
admet-276	95	23	neonatal	neonatal	ADJ
admet-276	95	24	fc	fc	PROPN
admet-276	95	25	receptor	receptor	NOUN
admet-276	95	26	(	(	PUNCT
admet-276	95	27	fcrn)-dependent	fcrn)-dependent	PROPN
admet-276	95	28	recycling	recycling	NOUN
admet-276	95	29	and	and	CCONJ
admet-276	95	30	fc	fc	PROPN
admet-276	95	31	(	(	PUNCT
admet-276	95	32	fragment	fragment	ADJ
admet-276	95	33	,	,	PUNCT
admet-276	95	34	crystallizable	crystallizable	ADJ
admet-276	95	35	)	)	PUNCT
admet-276	95	36	effector	effector	NOUN
admet-276	95	37	functions	function	NOUN
admet-276	95	38	[	[	X
admet-276	95	39	24	24	NUM
admet-276	95	40	]	]	PUNCT
admet-276	95	41	.	.	PUNCT
admet-276	96	1	compared	compare	VERB
admet-276	96	2	with	with	ADP
admet-276	96	3	the	the	DET
admet-276	96	4	unconjugated	unconjugated	ADJ
admet-276	96	5	antibody	antibody	NOUN
admet-276	96	6	,	,	PUNCT
admet-276	96	7	adcs	adcs	PROPN
admet-276	96	8	can	can	AUX
admet-276	96	9	exhibit	exhibit	VERB
admet-276	96	10	somewhat	somewhat	ADV
admet-276	96	11	higher	high	ADJ
admet-276	96	12	clearance	clearance	NOUN
admet-276	96	13	due	due	ADP
admet-276	96	14	to	to	ADP
admet-276	96	15	introduction	introduction	NOUN
admet-276	96	16	of	of	ADP
admet-276	96	17	an	an	DET
admet-276	96	18	additional	additional	ADJ
admet-276	96	19	metabolic	metabolic	NOUN
admet-276	96	20	pathway	pathway	NOUN
admet-276	96	21	(	(	PUNCT
admet-276	96	22	i.e.	i.e.	X
admet-276	96	23	cleavage	cleavage	NOUN
admet-276	96	24	of	of	ADP
admet-276	96	25	the	the	DET
admet-276	96	26	drug	drug	NOUN
admet-276	96	27	from	from	ADP
admet-276	96	28	the	the	DET
admet-276	96	29	antibody	antibody	NOUN
admet-276	96	30	by	by	ADP
admet-276	96	31	lysosomal	lysosomal	ADJ
admet-276	96	32	peptide	peptide	NOUN
admet-276	96	33	degradation	degradation	NOUN
admet-276	96	34	)	)	PUNCT
admet-276	96	35	.	.	PUNCT
admet-276	97	1	furthermore	furthermore	ADV
admet-276	97	2	,	,	PUNCT
admet-276	97	3	linker	linker	NOUN
admet-276	97	4	stability	stability	NOUN
admet-276	97	5	,	,	PUNCT
admet-276	97	6	dar	dar	NOUN
admet-276	97	7	and	and	CCONJ
admet-276	97	8	site	site	NOUN
admet-276	97	9	of	of	ADP
admet-276	97	10	drug	drug	NOUN
admet-276	97	11	conjugation	conjugation	NOUN
admet-276	97	12	can	can	AUX
admet-276	97	13	largely	largely	ADV
admet-276	97	14	impact	impact	VERB
admet-276	97	15	pk	pk	NOUN
admet-276	97	16	behaviors	behavior	NOUN
admet-276	97	17	and	and	CCONJ
admet-276	97	18	distribution	distribution	NOUN
admet-276	97	19	as	as	ADV
admet-276	97	20	well	well	ADV
admet-276	97	21	.	.	PUNCT
admet-276	98	1	conjugation	conjugation	NOUN
admet-276	98	2	with	with	ADP
admet-276	98	3	higher	high	ADJ
admet-276	98	4	dar	dar	NOUN
admet-276	98	5	tends	tend	VERB
admet-276	98	6	to	to	PART
admet-276	98	7	have	have	VERB
admet-276	98	8	faster	fast	ADJ
admet-276	98	9	clearance	clearance	NOUN
admet-276	98	10	than	than	ADP
admet-276	98	11	conjugation	conjugation	NOUN
admet-276	98	12	with	with	ADP
admet-276	98	13	lower	low	ADJ
admet-276	98	14	dar	dar	NOUN
admet-276	98	15	as	as	ADP
admet-276	98	16	an	an	DET
admet-276	98	17	example	example	NOUN
admet-276	98	18	of	of	ADP
admet-276	98	19	cac10	cac10	PROPN
admet-276	98	20	-	-	PUNCT
admet-276	98	21	vc	vc	PROPN
admet-276	98	22	mmae	mmae	PROPN
admet-276	98	23	adcs	adcs	ADJ
admet-276	98	24	with	with	ADP
admet-276	98	25	high	high	ADJ
admet-276	98	26	dars	dar	NOUN
admet-276	98	27	exhibiting	exhibit	VERB
admet-276	98	28	a	a	DET
admet-276	98	29	faster	fast	ADJ
admet-276	98	30	total	total	ADJ
admet-276	98	31	antibody	antibody	NOUN
admet-276	98	32	clearance	clearance	NOUN
admet-276	98	33	than	than	ADP
admet-276	98	34	lower	low	ADJ
admet-276	98	35	dar	dar	PROPN
admet-276	98	36	adcs	adcs	NOUN
admet-276	99	1	[	[	X
admet-276	99	2	47	47	NUM
admet-276	99	3	]	]	PUNCT
admet-276	99	4	.	.	PUNCT
admet-276	100	1	variable	variable	ADJ
admet-276	100	2	dars	dar	NOUN
admet-276	100	3	and	and	CCONJ
admet-276	100	4	attachment	attachment	NOUN
admet-276	100	5	sites	site	NOUN
admet-276	100	6	by	by	ADP
admet-276	100	7	a	a	DET
admet-276	100	8	consequence	consequence	NOUN
admet-276	100	9	of	of	ADP
admet-276	100	10	current	current	ADJ
admet-276	100	11	random	random	ADJ
admet-276	100	12	conjugation	conjugation	NOUN
admet-276	100	13	methods	method	NOUN
admet-276	100	14	result	result	VERB
admet-276	100	15	in	in	ADP
admet-276	100	16	heterogeneous	heterogeneous	ADJ
admet-276	100	17	adcs	adc	NOUN
admet-276	100	18	with	with	ADP
admet-276	100	19	pk	pk	NOUN
admet-276	100	20	parameters	parameter	NOUN
admet-276	100	21	that	that	PRON
admet-276	100	22	can	can	AUX
admet-276	100	23	vary	vary	VERB
admet-276	100	24	substantially	substantially	ADV
admet-276	100	25	compared	compare	VERB
admet-276	100	26	to	to	ADP
admet-276	100	27	the	the	DET
admet-276	100	28	unconjugated	unconjugated	ADJ
admet-276	100	29	antibody	antibody	NOUN
admet-276	100	30	[	[	X
admet-276	100	31	24	24	NUM
admet-276	100	32	]	]	PUNCT
admet-276	100	33	.	.	PUNCT
admet-276	101	1	hamblett	hamblett	PROPN
admet-276	101	2	et	et	PROPN
admet-276	101	3	al	al	PROPN
admet-276	101	4	.	.	PROPN
admet-276	101	5	compared	compare	VERB
admet-276	101	6	adcs	adcs	ADV
admet-276	101	7	with	with	ADP
admet-276	101	8	different	different	ADJ
admet-276	101	9	admet	admet	PROPN
admet-276	101	10	&	&	CCONJ
admet-276	101	11	dmpk	dmpk	PROPN
admet-276	101	12	4(1	4(1	NOUN
admet-276	101	13	)	)	PUNCT
admet-276	101	14	(	(	PUNCT
admet-276	101	15	2016	2016	NUM
admet-276	101	16	)	)	PUNCT
admet-276	101	17	1	1	NUM
admet-276	101	18	-	-	SYM
admet-276	101	19	22	22	NUM
admet-276	101	20	adme	adme	NOUN
admet-276	101	21	testing	testing	NOUN
admet-276	101	22	of	of	ADP
admet-276	101	23	large	large	ADJ
admet-276	101	24	biologics	biologic	NOUN
admet-276	101	25	doi	doi	NOUN
admet-276	101	26	:	:	PUNCT
admet-276	101	27	10.5599	10.5599	NUM
admet-276	101	28	/	/	SYM
admet-276	101	29	admet.4.1.276	admet.4.1.276	NUM
admet-276	101	30	7	7	NUM
admet-276	101	31	drug	drug	NOUN
admet-276	101	32	loading	loading	NOUN
admet-276	101	33	(	(	PUNCT
admet-276	101	34	mmae	mmae	NOUN
admet-276	101	35	conjugated	conjugate	VERB
admet-276	101	36	to	to	ADP
admet-276	101	37	the	the	DET
admet-276	101	38	anti	anti	ADJ
admet-276	101	39	-	-	ADJ
admet-276	101	40	cd30	cd30	ADJ
admet-276	101	41	mab	mab	NOUN
admet-276	101	42	)	)	PUNCT
admet-276	101	43	and	and	CCONJ
admet-276	101	44	concluded	conclude	VERB
admet-276	101	45	that	that	SCONJ
admet-276	101	46	the	the	DET
admet-276	101	47	therapeutic	therapeutic	ADJ
admet-276	101	48	index	index	NOUN
admet-276	101	49	was	be	AUX
admet-276	101	50	increased	increase	VERB
admet-276	101	51	by	by	ADP
admet-276	101	52	decreasing	decrease	VERB
admet-276	101	53	drug	drug	NOUN
admet-276	101	54	loading	loading	NOUN
admet-276	101	55	per	per	ADP
admet-276	101	56	antibody	antibody	NOUN
admet-276	101	57	,	,	PUNCT
admet-276	101	58	demonstrating	demonstrate	VERB
admet-276	101	59	that	that	SCONJ
admet-276	101	60	drug	drug	NOUN
admet-276	101	61	loading	loading	NOUN
admet-276	101	62	is	be	AUX
admet-276	101	63	a	a	DET
admet-276	101	64	key	key	ADJ
admet-276	101	65	design	design	NOUN
admet-276	101	66	parameter	parameter	NOUN
admet-276	101	67	for	for	ADP
admet-276	101	68	antibody	antibody	NOUN
admet-276	101	69	-	-	PUNCT
admet-276	101	70	drug	drug	NOUN
admet-276	101	71	conjugates	conjugate	NOUN
admet-276	101	72	[	[	X
admet-276	101	73	47	47	NUM
admet-276	101	74	]	]	PUNCT
admet-276	101	75	.	.	PUNCT
admet-276	102	1	it	it	PRON
admet-276	102	2	was	be	AUX
admet-276	102	3	shown	show	VERB
admet-276	102	4	that	that	SCONJ
admet-276	102	5	the	the	DET
admet-276	102	6	terminal	terminal	ADJ
admet-276	102	7	half	half	ADJ
admet-276	102	8	-	-	PUNCT
admet-276	102	9	lives	life	NOUN
admet-276	102	10	did	do	AUX
admet-276	102	11	not	not	PART
admet-276	102	12	directly	directly	ADV
admet-276	102	13	correlate	correlate	VERB
admet-276	102	14	with	with	ADP
admet-276	102	15	drug	drug	NOUN
admet-276	102	16	loading	loading	NOUN
admet-276	102	17	.	.	PUNCT
admet-276	103	1	when	when	SCONJ
admet-276	103	2	the	the	DET
admet-276	103	3	drug	drug	NOUN
admet-276	103	4	loading	loading	NOUN
admet-276	103	5	increased	increase	VERB
admet-276	103	6	,	,	PUNCT
admet-276	103	7	both	both	CCONJ
admet-276	103	8	clearance	clearance	NOUN
admet-276	103	9	and	and	CCONJ
admet-276	103	10	volume	volume	NOUN
admet-276	103	11	of	of	ADP
admet-276	103	12	distribution	distribution	NOUN
admet-276	103	13	increased	increase	VERB
admet-276	103	14	,	,	PUNCT
admet-276	103	15	but	but	CCONJ
admet-276	103	16	the	the	DET
admet-276	103	17	exposure	exposure	NOUN
admet-276	103	18	(	(	PUNCT
admet-276	103	19	auc	auc	NOUN
admet-276	103	20	)	)	PUNCT
admet-276	103	21	of	of	ADP
admet-276	103	22	adc	adc	PROPN
admet-276	103	23	decreased	decrease	VERB
admet-276	103	24	,	,	PUNCT
admet-276	103	25	reflecting	reflect	VERB
admet-276	103	26	the	the	DET
admet-276	103	27	significant	significant	ADJ
admet-276	103	28	attribute	attribute	NOUN
admet-276	103	29	of	of	ADP
admet-276	103	30	dar	dar	PROPN
admet-276	103	31	to	to	ADP
admet-276	103	32	pk	pk	NOUN
admet-276	103	33	properties	property	NOUN
admet-276	103	34	of	of	ADP
admet-276	103	35	adc	adc	PROPN
admet-276	103	36	.	.	PUNCT
admet-276	104	1	the	the	DET
admet-276	104	2	systemic	systemic	ADJ
admet-276	104	3	stability	stability	NOUN
admet-276	104	4	of	of	ADP
admet-276	104	5	the	the	DET
admet-276	104	6	antibody−drug	antibody−drug	ADJ
admet-276	104	7	linker	linker	NOUN
admet-276	104	8	is	be	AUX
admet-276	104	9	also	also	ADV
admet-276	104	10	crucial	crucial	ADJ
admet-276	104	11	for	for	ADP
admet-276	104	12	delivery	delivery	NOUN
admet-276	104	13	of	of	ADP
admet-276	104	14	an	an	DET
admet-276	104	15	intact	intact	ADJ
admet-276	104	16	adc	adc	NOUN
admet-276	104	17	to	to	ADP
admet-276	104	18	targetexpressing	targetexpresse	VERB
admet-276	104	19	tumors	tumor	NOUN
admet-276	104	20	.	.	PUNCT
admet-276	105	1	linkers	linker	NOUN
admet-276	105	2	stable	stable	ADJ
admet-276	105	3	in	in	ADP
admet-276	105	4	circulation	circulation	NOUN
admet-276	105	5	but	but	CCONJ
admet-276	105	6	readily	readily	ADV
admet-276	105	7	processed	process	VERB
admet-276	105	8	in	in	ADP
admet-276	105	9	the	the	DET
admet-276	105	10	target	target	NOUN
admet-276	105	11	cell	cell	NOUN
admet-276	105	12	are	be	AUX
admet-276	105	13	necessary	necessary	ADJ
admet-276	105	14	for	for	ADP
admet-276	105	15	both	both	PRON
admet-276	105	16	safety	safety	NOUN
admet-276	105	17	and	and	CCONJ
admet-276	105	18	potency	potency	NOUN
admet-276	105	19	of	of	ADP
admet-276	105	20	the	the	DET
admet-276	105	21	delivered	deliver	VERB
admet-276	105	22	conjugate	conjugate	NOUN
admet-276	106	1	[	[	X
admet-276	106	2	48	48	NUM
admet-276	106	3	]	]	PUNCT
admet-276	106	4	.	.	PUNCT
admet-276	107	1	in	in	ADP
admet-276	107	2	general	general	ADJ
admet-276	107	3	,	,	PUNCT
admet-276	107	4	linker	linker	NOUN
admet-276	107	5	should	should	AUX
admet-276	107	6	be	be	AUX
admet-276	107	7	stable	stable	ADJ
admet-276	107	8	enough	enough	ADV
admet-276	107	9	in	in	ADP
admet-276	107	10	systemic	systemic	ADJ
admet-276	107	11	circulation	circulation	NOUN
admet-276	107	12	to	to	PART
admet-276	107	13	deliver	deliver	VERB
admet-276	107	14	drug	drug	NOUN
admet-276	107	15	into	into	ADP
admet-276	107	16	tumor	tumor	NOUN
admet-276	107	17	cells	cell	NOUN
admet-276	107	18	,	,	PUNCT
admet-276	107	19	but	but	CCONJ
admet-276	107	20	labile	labile	ADJ
admet-276	107	21	to	to	PART
admet-276	107	22	release	release	VERB
admet-276	107	23	this	this	DET
admet-276	107	24	fully	fully	ADV
admet-276	107	25	active	active	ADJ
admet-276	107	26	payload	payload	NOUN
admet-276	107	27	drug	drug	NOUN
admet-276	107	28	inside	inside	ADP
admet-276	107	29	the	the	DET
admet-276	107	30	tumor	tumor	NOUN
admet-276	107	31	cells	cell	NOUN
admet-276	107	32	.	.	PUNCT
admet-276	108	1	otherwise	otherwise	ADV
admet-276	108	2	,	,	PUNCT
admet-276	108	3	the	the	DET
admet-276	108	4	toxic	toxic	ADJ
admet-276	108	5	drug	drug	NOUN
admet-276	108	6	could	could	AUX
admet-276	108	7	be	be	AUX
admet-276	108	8	released	release	VERB
admet-276	108	9	in	in	ADP
admet-276	108	10	the	the	DET
admet-276	108	11	bloodstream	bloodstream	NOUN
admet-276	108	12	,	,	PUNCT
admet-276	108	13	causing	cause	VERB
admet-276	108	14	systemic	systemic	ADJ
admet-276	108	15	toxicity	toxicity	NOUN
admet-276	108	16	.	.	PUNCT
admet-276	109	1	polson	polson	PROPN
admet-276	109	2	et	et	PROPN
admet-276	109	3	al	al	PROPN
admet-276	109	4	.	.	PROPN
admet-276	109	5	demonstrated	demonstrate	VERB
admet-276	109	6	that	that	SCONJ
admet-276	109	7	non	non	ADJ
admet-276	109	8	-	-	ADJ
admet-276	109	9	cleavable	cleavable	ADJ
admet-276	109	10	linker	linker	NOUN
admet-276	109	11	(	(	PUNCT
admet-276	109	12	e.g.	e.g.	ADV
admet-276	109	13	sgn-35	sgn-35	X
admet-276	109	14	)	)	PUNCT
admet-276	109	15	is	be	AUX
admet-276	109	16	more	more	ADV
admet-276	109	17	stable	stable	ADJ
admet-276	109	18	than	than	ADP
admet-276	109	19	cleavable	cleavable	ADJ
admet-276	109	20	linker	linker	NOUN
admet-276	109	21	(	(	PUNCT
admet-276	109	22	e.g.	e.g.	ADV
admet-276	109	23	t	t	PROPN
admet-276	109	24	-	-	PUNCT
admet-276	109	25	dm1	dm1	NOUN
admet-276	109	26	)	)	PUNCT
admet-276	110	1	[	[	X
admet-276	110	2	49	49	NUM
admet-276	110	3	]	]	PUNCT
admet-276	110	4	.	.	PUNCT
admet-276	111	1	the	the	DET
admet-276	111	2	non	non	ADJ
admet-276	111	3	-	-	ADJ
admet-276	111	4	cleavable	cleavable	ADJ
admet-276	111	5	linker	linker	NOUN
admet-276	111	6	may	may	AUX
admet-276	111	7	have	have	VERB
admet-276	111	8	slower	slow	ADJ
admet-276	111	9	deconjugation	deconjugation	NOUN
admet-276	111	10	or	or	CCONJ
admet-276	111	11	lower	low	ADJ
admet-276	111	12	clearance	clearance	NOUN
admet-276	111	13	than	than	ADP
admet-276	111	14	cleavable	cleavable	ADJ
admet-276	111	15	linker	linker	NOUN
admet-276	111	16	and	and	CCONJ
admet-276	111	17	reduced	reduce	VERB
admet-276	111	18	systemic	systemic	ADJ
admet-276	111	19	toxicity	toxicity	NOUN
admet-276	111	20	of	of	ADP
admet-276	111	21	adc	adc	PROPN
admet-276	111	22	in	in	ADP
admet-276	111	23	rats	rat	NOUN
admet-276	111	24	presumably	presumably	ADV
admet-276	111	25	due	due	ADP
admet-276	111	26	to	to	ADP
admet-276	111	27	the	the	DET
admet-276	111	28	reduced	reduce	VERB
admet-276	111	29	release	release	NOUN
admet-276	111	30	of	of	ADP
admet-276	111	31	free	free	ADJ
admet-276	111	32	drug	drug	NOUN
admet-276	111	33	or	or	CCONJ
admet-276	111	34	other	other	ADJ
admet-276	111	35	toxic	toxic	ADJ
admet-276	111	36	metabolites	metabolite	NOUN
admet-276	111	37	into	into	ADP
admet-276	111	38	the	the	DET
admet-276	111	39	circulation	circulation	NOUN
admet-276	111	40	[	[	X
admet-276	111	41	49	49	NUM
admet-276	111	42	]	]	PUNCT
admet-276	111	43	.	.	PUNCT
admet-276	112	1	this	this	PRON
admet-276	112	2	is	be	AUX
admet-276	112	3	because	because	SCONJ
admet-276	112	4	the	the	DET
admet-276	112	5	cleavable	cleavable	ADJ
admet-276	112	6	linkers	linker	NOUN
admet-276	112	7	may	may	AUX
admet-276	112	8	release	release	VERB
admet-276	112	9	drug	drug	NOUN
admet-276	112	10	by	by	ADP
admet-276	112	11	lysosomal	lysosomal	ADJ
admet-276	112	12	proteases	protease	NOUN
admet-276	112	13	without	without	ADP
admet-276	112	14	the	the	DET
admet-276	112	15	degradation	degradation	NOUN
admet-276	112	16	of	of	ADP
admet-276	112	17	the	the	DET
admet-276	112	18	mab	mab	NOUN
admet-276	112	19	component	component	NOUN
admet-276	112	20	whereas	whereas	SCONJ
admet-276	112	21	non	non	ADJ
admet-276	112	22	-	-	ADJ
admet-276	112	23	cleavable	cleavable	ADJ
admet-276	112	24	linkers	linker	NOUN
admet-276	112	25	require	require	VERB
admet-276	112	26	catabolism	catabolism	NOUN
admet-276	112	27	of	of	ADP
admet-276	112	28	the	the	DET
admet-276	112	29	mab	mab	NOUN
admet-276	112	30	backbones	backbone	NOUN
admet-276	112	31	to	to	PART
admet-276	112	32	release	release	VERB
admet-276	112	33	the	the	DET
admet-276	112	34	drug	drug	NOUN
admet-276	112	35	[	[	X
admet-276	112	36	9	9	NUM
admet-276	112	37	and	and	CCONJ
admet-276	112	38	ref	ref	NOUN
admet-276	112	39	.	.	PUNCT
admet-276	113	1	therein	therein	ADV
admet-276	113	2	]	]	PUNCT
admet-276	113	3	.	.	PUNCT
admet-276	114	1	in	in	ADP
admet-276	114	2	addition	addition	NOUN
admet-276	114	3	,	,	PUNCT
admet-276	114	4	the	the	DET
admet-276	114	5	selection	selection	NOUN
admet-276	114	6	of	of	ADP
admet-276	114	7	attachment	attachment	NOUN
admet-276	114	8	site	site	NOUN
admet-276	114	9	can	can	AUX
admet-276	114	10	affect	affect	VERB
admet-276	114	11	stability	stability	NOUN
admet-276	114	12	of	of	ADP
admet-276	114	13	cleavable	cleavable	ADJ
admet-276	114	14	antibody	antibody	NOUN
admet-276	114	15	-	-	PUNCT
admet-276	114	16	drug	drug	NOUN
admet-276	114	17	conjugates	conjugate	NOUN
admet-276	114	18	,	,	PUNCT
admet-276	114	19	as	as	SCONJ
admet-276	114	20	demonstrated	demonstrate	VERB
admet-276	114	21	in	in	ADP
admet-276	114	22	the	the	DET
admet-276	114	23	design	design	NOUN
admet-276	114	24	of	of	ADP
admet-276	114	25	systemically	systemically	ADV
admet-276	114	26	stable	stable	ADJ
admet-276	114	27	cleavable	cleavable	ADJ
admet-276	114	28	auristatin	auristatin	ADV
admet-276	114	29	-	-	PUNCT
admet-276	114	30	based	base	VERB
admet-276	114	31	conjugates	conjugate	NOUN
admet-276	114	32	,	,	PUNCT
admet-276	114	33	offering	offer	VERB
admet-276	114	34	the	the	DET
admet-276	114	35	means	mean	NOUN
admet-276	114	36	to	to	PART
admet-276	114	37	overcome	overcome	VERB
admet-276	114	38	inherent	inherent	ADJ
admet-276	114	39	linker	linker	NOUN
admet-276	114	40	instability	instability	NOUN
admet-276	114	41	by	by	ADP
admet-276	114	42	optimal	optimal	ADJ
admet-276	114	43	attachment	attachment	NOUN
admet-276	114	44	site	site	NOUN
admet-276	114	45	[	[	X
admet-276	114	46	48	48	NUM
admet-276	114	47	]	]	PUNCT
admet-276	114	48	.	.	PUNCT
admet-276	115	1	interestingly	interestingly	ADV
admet-276	115	2	,	,	PUNCT
admet-276	115	3	junutula	junutula	PROPN
admet-276	115	4	et	et	PROPN
admet-276	115	5	al	al	PROPN
admet-276	115	6	.	.	PUNCT
admet-276	116	1	[	[	X
admet-276	116	2	50	50	NUM
admet-276	116	3	]	]	PUNCT
admet-276	116	4	recently	recently	ADV
admet-276	116	5	reported	report	VERB
admet-276	116	6	a	a	DET
admet-276	116	7	site	site	NOUN
admet-276	116	8	-	-	PUNCT
admet-276	116	9	specific	specific	ADJ
admet-276	116	10	conjugation	conjugation	NOUN
admet-276	116	11	method	method	NOUN
admet-276	116	12	called	call	VERB
admet-276	116	13	thiomab	thiomab	NOUN
admet-276	116	14	technology	technology	NOUN
admet-276	116	15	enabling	enable	VERB
admet-276	116	16	near	near	ADJ
admet-276	116	17	-	-	PUNCT
admet-276	116	18	uniform	uniform	ADJ
admet-276	116	19	,	,	PUNCT
admet-276	116	20	low	low	ADJ
admet-276	116	21	-	-	PUNCT
admet-276	116	22	level	level	NOUN
admet-276	116	23	conjugation	conjugation	NOUN
admet-276	116	24	of	of	ADP
admet-276	116	25	cytotoxins	cytotoxin	NOUN
admet-276	116	26	(	(	PUNCT
admet-276	116	27	dar=2	dar=2	INTJ
admet-276	116	28	)	)	PUNCT
admet-276	116	29	to	to	ADP
admet-276	116	30	antitumor	antitumor	PROPN
admet-276	116	31	antibodies	antibodie	VERB
admet-276	116	32	,	,	PUNCT
admet-276	116	33	which	which	PRON
admet-276	116	34	displayed	display	VERB
admet-276	116	35	an	an	DET
admet-276	116	36	increased	increase	VERB
admet-276	116	37	tolerability	tolerability	NOUN
admet-276	116	38	or	or	CCONJ
admet-276	116	39	improved	improve	VERB
admet-276	116	40	therapeutic	therapeutic	ADJ
admet-276	116	41	index	index	NOUN
admet-276	116	42	without	without	ADP
admet-276	116	43	compromising	compromise	VERB
admet-276	116	44	efficacy	efficacy	NOUN
admet-276	116	45	.	.	PUNCT
admet-276	117	1	this	this	DET
admet-276	117	2	new	new	ADJ
admet-276	117	3	type	type	NOUN
admet-276	117	4	of	of	ADP
admet-276	117	5	thiomab	thiomab	NOUN
admet-276	117	6	-	-	PUNCT
admet-276	117	7	drug	drug	NOUN
admet-276	117	8	conjugates	conjugate	NOUN
admet-276	117	9	(	(	PUNCT
admet-276	117	10	tdcs	tdcs	ADV
admet-276	117	11	)	)	PUNCT
admet-276	117	12	with	with	ADP
admet-276	117	13	nearly	nearly	ADV
admet-276	117	14	homogeneous	homogeneous	ADJ
admet-276	117	15	composition	composition	NOUN
admet-276	117	16	of	of	ADP
admet-276	117	17	conjugates	conjugate	NOUN
admet-276	117	18	was	be	AUX
admet-276	117	19	better	well	ADV
admet-276	117	20	tolerated	tolerate	VERB
admet-276	117	21	than	than	ADP
admet-276	117	22	conventional	conventional	ADJ
admet-276	117	23	adc	adc	PROPN
admet-276	117	24	in	in	ADP
admet-276	117	25	monkeys	monkey	NOUN
admet-276	117	26	,	,	PUNCT
admet-276	117	27	and	and	CCONJ
admet-276	117	28	also	also	ADV
admet-276	117	29	showed	show	VERB
admet-276	117	30	slower	slow	ADJ
admet-276	117	31	catabolism	catabolism	NOUN
admet-276	117	32	and	and	CCONJ
admet-276	117	33	deconjugation	deconjugation	NOUN
admet-276	117	34	than	than	ADP
admet-276	117	35	adc	adc	PROPN
admet-276	117	36	in	in	ADP
admet-276	117	37	rats	rat	NOUN
admet-276	117	38	.	.	PUNCT
admet-276	118	1	the	the	DET
admet-276	118	2	thiomab	thiomab	NOUN
admet-276	118	3	approach	approach	NOUN
admet-276	118	4	provides	provide	VERB
admet-276	118	5	a	a	DET
admet-276	118	6	general	general	ADJ
admet-276	118	7	strategy	strategy	NOUN
admet-276	118	8	for	for	ADP
admet-276	118	9	improved	improved	ADJ
admet-276	118	10	pk	pk	NOUN
admet-276	118	11	and	and	CCONJ
admet-276	118	12	superior	superior	ADJ
admet-276	118	13	therapeutic	therapeutic	ADJ
admet-276	118	14	index	index	NOUN
admet-276	118	15	of	of	ADP
admet-276	118	16	any	any	DET
admet-276	118	17	adc	adc	NOUN
admet-276	118	18	generated	generate	VERB
admet-276	118	19	by	by	ADP
admet-276	118	20	standard	standard	ADJ
admet-276	118	21	sufhydryl	sufhydryl	PROPN
admet-276	118	22	-	-	PUNCT
admet-276	118	23	directed	direct	VERB
admet-276	118	24	maleimide	maleimide	ADJ
admet-276	118	25	chemistry	chemistry	NOUN
admet-276	118	26	[	[	X
admet-276	118	27	51	51	NUM
admet-276	118	28	]	]	PUNCT
admet-276	118	29	.	.	PUNCT
admet-276	119	1	likewise	likewise	ADV
admet-276	119	2	,	,	PUNCT
admet-276	119	3	dennler	dennler	NOUN
admet-276	119	4	et	et	PROPN
admet-276	119	5	al	al	PROPN
admet-276	119	6	.	.	PROPN
admet-276	120	1	more	more	ADV
admet-276	120	2	recently	recently	ADV
admet-276	120	3	presented	present	VERB
admet-276	120	4	another	another	DET
admet-276	120	5	site	site	NOUN
admet-276	120	6	-	-	PUNCT
admet-276	120	7	specific	specific	ADJ
admet-276	120	8	modification	modification	NOUN
admet-276	120	9	of	of	ADP
admet-276	120	10	deglycosylated	deglycosylate	VERB
admet-276	120	11	antibodies	antibody	NOUN
admet-276	120	12	by	by	ADP
admet-276	120	13	microbial	microbial	ADJ
admet-276	120	14	transglutaminase	transglutaminase	NOUN
admet-276	120	15	(	(	PUNCT
admet-276	120	16	mtgase	mtgase	NOUN
admet-276	120	17	)	)	PUNCT
admet-276	120	18	to	to	PART
admet-276	120	19	form	form	VERB
admet-276	120	20	adcs	adcs	ADV
admet-276	120	21	with	with	ADP
admet-276	120	22	a	a	DET
admet-276	120	23	defined	define	VERB
admet-276	120	24	homogeneous	homogeneous	ADJ
admet-276	120	25	dar	dar	NOUN
admet-276	120	26	of	of	ADP
admet-276	120	27	2	2	NUM
admet-276	120	28	as	as	ADV
admet-276	120	29	well	well	ADV
admet-276	120	30	.	.	PUNCT
admet-276	121	1	this	this	DET
admet-276	121	2	chemo	chemo	NOUN
admet-276	121	3	-	-	PUNCT
admet-276	121	4	enzymatic	enzymatic	ADJ
admet-276	121	5	approach	approach	NOUN
admet-276	121	6	was	be	AUX
admet-276	121	7	reported	report	VERB
admet-276	121	8	directly	directly	ADV
admet-276	121	9	applicable	applicable	ADJ
admet-276	121	10	to	to	ADP
admet-276	121	11	abroad	abroad	ADJ
admet-276	121	12	variety	variety	NOUN
admet-276	121	13	of	of	ADP
admet-276	121	14	antibodies	antibody	NOUN
admet-276	121	15	as	as	SCONJ
admet-276	121	16	it	it	PRON
admet-276	121	17	does	do	AUX
admet-276	121	18	not	not	PART
admet-276	121	19	require	require	VERB
admet-276	121	20	prior	prior	ADJ
admet-276	121	21	genetic	genetic	ADJ
admet-276	121	22	modifications	modification	NOUN
admet-276	121	23	of	of	ADP
admet-276	121	24	the	the	DET
admet-276	121	25	antibody	antibody	NOUN
admet-276	121	26	sequence	sequence	NOUN
admet-276	122	1	[	[	X
admet-276	122	2	52	52	NUM
admet-276	122	3	]	]	PUNCT
admet-276	122	4	.	.	PUNCT
admet-276	123	1	clearly	clearly	ADV
admet-276	123	2	,	,	PUNCT
admet-276	123	3	the	the	DET
admet-276	123	4	designing	designing	NOUN
admet-276	123	5	and	and	CCONJ
admet-276	123	6	forming	form	VERB
admet-276	123	7	a	a	DET
admet-276	123	8	homogeneous	homogeneous	ADJ
admet-276	123	9	adc	adc	NOUN
admet-276	123	10	can	can	AUX
admet-276	123	11	result	result	VERB
admet-276	123	12	in	in	ADP
admet-276	123	13	less	less	ADV
admet-276	123	14	complicated	complicated	ADJ
admet-276	123	15	in	in	ADP
admet-276	123	16	vitro	vitro	X
admet-276	123	17	characterization	characterization	NOUN
admet-276	123	18	and	and	CCONJ
admet-276	123	19	relatively	relatively	ADV
admet-276	123	20	easier	easy	ADJ
admet-276	123	21	in	in	ADP
admet-276	123	22	vivo	vivo	ADJ
admet-276	123	23	pk	pk	NOUN
admet-276	123	24	bioanalysis	bioanalysis	NOUN
admet-276	123	25	as	as	ADV
admet-276	123	26	well	well	ADV
admet-276	123	27	as	as	ADP
admet-276	123	28	safety	safety	NOUN
admet-276	123	29	evaluation	evaluation	NOUN
admet-276	123	30	than	than	ADP
admet-276	123	31	a	a	DET
admet-276	123	32	typical	typical	ADJ
admet-276	123	33	heterogeneous	heterogeneous	ADJ
admet-276	123	34	adc	adc	PROPN
admet-276	123	35	.	.	PUNCT
admet-276	124	1	apart	apart	ADV
admet-276	124	2	from	from	ADP
admet-276	124	3	the	the	DET
admet-276	124	4	dar	dar	NOUN
admet-276	124	5	characterization	characterization	NOUN
admet-276	124	6	,	,	PUNCT
admet-276	124	7	some	some	PRON
admet-276	124	8	in	in	ADP
admet-276	124	9	vitro	vitro	X
admet-276	124	10	adme	adme	NOUN
admet-276	124	11	models	model	NOUN
admet-276	124	12	and	and	CCONJ
admet-276	124	13	in	in	ADP
admet-276	124	14	vivo	vivo	ADJ
admet-276	124	15	pk	pk	NOUN
admet-276	124	16	studies	study	NOUN
admet-276	124	17	can	can	AUX
admet-276	124	18	be	be	AUX
admet-276	124	19	employed	employ	VERB
admet-276	124	20	for	for	ADP
admet-276	124	21	adc	adc	PROPN
admet-276	124	22	evaluations	evaluation	NOUN
admet-276	124	23	as	as	SCONJ
admet-276	124	24	illustrated	illustrate	VERB
admet-276	124	25	in	in	ADP
admet-276	124	26	figure	figure	NOUN
admet-276	124	27	1	1	NUM
admet-276	124	28	.	.	PUNCT
admet-276	125	1	first	first	ADJ
admet-276	125	2	adme	adme	NOUN
admet-276	125	3	testing	testing	NOUN
admet-276	125	4	of	of	ADP
admet-276	125	5	adcs	adcs	PROPN
admet-276	125	6	is	be	AUX
admet-276	125	7	linker	linker	NOUN
admet-276	125	8	stability	stability	NOUN
admet-276	125	9	assessment	assessment	NOUN
admet-276	125	10	both	both	CCONJ
admet-276	125	11	in	in	ADP
admet-276	125	12	in	in	ADP
admet-276	125	13	vitro	vitro	X
admet-276	125	14	or	or	CCONJ
admet-276	125	15	in	in	ADP
admet-276	125	16	vivo	vivo	NOUN
admet-276	125	17	by	by	ADP
admet-276	125	18	lc	lc	PROPN
admet-276	125	19	-	-	PUNCT
admet-276	125	20	ms	ms	PROPN
admet-276	125	21	/	/	SYM
admet-276	125	22	ms	ms	PROPN
admet-276	125	23	method	method	NOUN
admet-276	125	24	or	or	CCONJ
admet-276	125	25	radiolabeled	radiolabele	VERB
admet-276	125	26	adc	adc	PROPN
admet-276	125	27	,	,	PUNCT
admet-276	125	28	respectively	respectively	ADV
admet-276	125	29	,	,	PUNCT
admet-276	125	30	in	in	ADP
admet-276	125	31	order	order	NOUN
admet-276	125	32	to	to	PART
admet-276	125	33	explore	explore	VERB
admet-276	125	34	the	the	DET
admet-276	125	35	impact	impact	NOUN
admet-276	125	36	of	of	ADP
admet-276	125	37	linker	linker	NOUN
admet-276	125	38	on	on	ADP
admet-276	125	39	uptake	uptake	NOUN
admet-276	125	40	and	and	CCONJ
admet-276	125	41	catabolism	catabolism	NOUN
admet-276	125	42	.	.	PUNCT
admet-276	126	1	secondly	secondly	ADV
admet-276	126	2	,	,	PUNCT
admet-276	126	3	free	free	ADJ
admet-276	126	4	toxin	toxin	NOUN
admet-276	126	5	was	be	AUX
admet-276	126	6	expected	expect	VERB
admet-276	126	7	to	to	PART
admet-276	126	8	undergo	undergo	VERB
admet-276	126	9	clearance	clearance	NOUN
admet-276	126	10	mechanism	mechanism	NOUN
admet-276	126	11	studies	study	NOUN
admet-276	126	12	for	for	ADP
admet-276	126	13	ddi	ddi	PROPN
admet-276	126	14	potential	potential	NOUN
admet-276	126	15	including	include	VERB
admet-276	126	16	liver	liver	NOUN
admet-276	126	17	microsomal	microsomal	ADJ
admet-276	126	18	stability	stability	NOUN
admet-276	126	19	,	,	PUNCT
admet-276	126	20	metabolizing	metabolize	VERB
admet-276	126	21	enzyme	enzyme	NOUN
admet-276	126	22	identification	identification	NOUN
admet-276	126	23	,	,	PUNCT
admet-276	126	24	cyp	cyp	ADJ
admet-276	126	25	inhibition	inhibition	NOUN
admet-276	126	26	and	and	CCONJ
admet-276	126	27	induction	induction	NOUN
admet-276	126	28	,	,	PUNCT
admet-276	126	29	in	in	ADP
admet-276	126	30	vitro	vitro	X
admet-276	126	31	metabolite	metabolite	NOUN
admet-276	126	32	profiling	profiling	NOUN
admet-276	126	33	studies	study	NOUN
admet-276	126	34	[	[	X
admet-276	126	35	53	53	NUM
admet-276	126	36	]	]	PUNCT
admet-276	126	37	.	.	PUNCT
admet-276	127	1	then	then	ADV
admet-276	127	2	,	,	PUNCT
admet-276	127	3	general	general	ADJ
admet-276	127	4	in	in	ADP
admet-276	127	5	vivo	vivo	ADJ
admet-276	127	6	pk	pk	NOUN
admet-276	127	7	studies	study	NOUN
admet-276	127	8	and	and	CCONJ
admet-276	127	9	non	non	ADJ
admet-276	127	10	-	-	ADJ
admet-276	127	11	clinical	clinical	ADJ
admet-276	127	12	safety	safety	NOUN
admet-276	127	13	evaluations	evaluation	NOUN
admet-276	127	14	including	include	VERB
admet-276	127	15	immunogenicity	immunogenicity	NOUN
admet-276	127	16	with	with	ADP
admet-276	127	17	relevant	relevant	ADJ
admet-276	127	18	animal	animal	NOUN
admet-276	127	19	species	specie	NOUN
admet-276	127	20	are	be	AUX
admet-276	127	21	necessary	necessary	ADJ
admet-276	127	22	for	for	ADP
admet-276	127	23	pcc	pcc	NOUN
admet-276	127	24	selection	selection	NOUN
admet-276	127	25	.	.	PUNCT
admet-276	128	1	finally	finally	ADV
admet-276	128	2	,	,	PUNCT
admet-276	128	3	linker	linker	NOUN
admet-276	128	4	-	-	PUNCT
admet-276	128	5	containing	contain	VERB
admet-276	128	6	drug	drug	NOUN
admet-276	128	7	catabolites	catabolite	NOUN
admet-276	128	8	should	should	AUX
admet-276	128	9	be	be	AUX
admet-276	128	10	identified	identify	VERB
admet-276	128	11	and	and	CCONJ
admet-276	128	12	the	the	DET
admet-276	128	13	plasma	plasma	NOUN
admet-276	128	14	concentration	concentration	NOUN
admet-276	128	15	of	of	ADP
admet-276	128	16	free	free	ADJ
admet-276	128	17	drug	drug	NOUN
admet-276	128	18	and	and	CCONJ
admet-276	128	19	related	relate	VERB
admet-276	128	20	catabolites	catabolite	NOUN
admet-276	128	21	should	should	AUX
admet-276	128	22	be	be	AUX
admet-276	128	23	determined	determine	VERB
admet-276	128	24	by	by	ADP
admet-276	128	25	lc	lc	PROPN
admet-276	128	26	-	-	PUNCT
admet-276	128	27	ms	ms	PROPN
admet-276	128	28	/	/	PROPN
admet-276	128	29	ms	ms	NOUN
admet-276	128	30	in	in	ADP
admet-276	128	31	both	both	CCONJ
admet-276	128	32	nonclinical	nonclinical	ADJ
admet-276	128	33	and	and	CCONJ
admet-276	128	34	clinical	clinical	ADJ
admet-276	128	35	studies	study	NOUN
admet-276	128	36	for	for	ADP
admet-276	128	37	safety	safety	NOUN
admet-276	128	38	assessment	assessment	NOUN
admet-276	128	39	of	of	ADP
admet-276	128	40	key	key	ADJ
admet-276	128	41	metabolites	metabolite	NOUN
admet-276	128	42	or	or	CCONJ
admet-276	128	43	catabolites	catabolite	NOUN
admet-276	128	44	.	.	PUNCT
admet-276	129	1	hong	hong	PROPN
admet-276	129	2	wan	wan	PROPN
admet-276	129	3	admet	admet	PROPN
admet-276	129	4	&	&	CCONJ
admet-276	129	5	dmpk	dmpk	PROPN
admet-276	129	6	4(1	4(1	NOUN
admet-276	129	7	)	)	PUNCT
admet-276	129	8	(	(	PUNCT
admet-276	129	9	2016	2016	NUM
admet-276	129	10	)	)	PUNCT
admet-276	129	11	1	1	NUM
admet-276	129	12	-	-	SYM
admet-276	129	13	22	22	NUM
admet-276	129	14	8	8	NUM
admet-276	129	15	elisa	elisa	NOUN
admet-276	129	16	was	be	AUX
admet-276	129	17	conventional	conventional	ADJ
admet-276	129	18	method	method	NOUN
admet-276	129	19	for	for	ADP
admet-276	129	20	pk	pk	NOUN
admet-276	129	21	/	/	SYM
admet-276	129	22	tk	tk	PROPN
admet-276	129	23	(	(	PUNCT
admet-276	129	24	toxicokinetics	toxicokinetic	NOUN
admet-276	129	25	)	)	PUNCT
admet-276	129	26	study	study	NOUN
admet-276	129	27	of	of	ADP
admet-276	129	28	antibody	antibody	NOUN
admet-276	129	29	and	and	CCONJ
admet-276	129	30	conjugate	conjugate	VERB
admet-276	129	31	.	.	PUNCT
admet-276	130	1	for	for	ADP
admet-276	130	2	instance	instance	NOUN
admet-276	130	3	,	,	PUNCT
admet-276	130	4	detection	detection	NOUN
admet-276	130	5	reagents	reagent	NOUN
admet-276	130	6	for	for	ADP
admet-276	130	7	total	total	ADJ
admet-276	130	8	and	and	CCONJ
admet-276	130	9	conjugated	conjugate	VERB
admet-276	130	10	antibodies	antibody	NOUN
admet-276	130	11	were	be	AUX
admet-276	130	12	goat	goat	PROPN
admet-276	130	13	antihuman	antihuman	NOUN
admet-276	130	14	igg	igg	PROPN
admet-276	130	15	antibody	antibody	NOUN
admet-276	130	16	conjugated	conjugate	VERB
admet-276	130	17	to	to	ADP
admet-276	130	18	horseradish	horseradish	ADJ
admet-276	130	19	peroxidase	peroxidase	NOUN
admet-276	130	20	or	or	CCONJ
admet-276	130	21	goat	goat	PROPN
admet-276	130	22	antihuman	antihuman	PROPN
admet-276	130	23	fc	fc	PROPN
admet-276	130	24	conjugated	conjugate	VERB
admet-276	130	25	to	to	ADP
admet-276	130	26	horseradish	horseradish	ADJ
admet-276	130	27	peroxidase	peroxidase	NOUN
admet-276	131	1	[	[	X
admet-276	131	2	43	43	NUM
admet-276	131	3	]	]	PUNCT
admet-276	131	4	.	.	PUNCT
admet-276	132	1	coat	coat	NOUN
admet-276	132	2	capture	capture	NOUN
admet-276	132	3	reagents	reagent	NOUN
admet-276	132	4	were	be	AUX
admet-276	132	5	used	use	VERB
admet-276	132	6	on	on	ADP
admet-276	132	7	a	a	DET
admet-276	132	8	case	case	NOUN
admet-276	132	9	by	by	ADP
admet-276	132	10	case	case	NOUN
admet-276	132	11	basis	basis	NOUN
admet-276	132	12	,	,	PUNCT
admet-276	132	13	e.g.	e.g.	ADV
admet-276	132	14	anti	anti	ADJ
admet-276	132	15	-	-	ADJ
admet-276	132	16	mmae	mmae	ADJ
admet-276	132	17	antibody	antibody	NOUN
admet-276	132	18	(	(	PUNCT
admet-276	132	19	conjugated	conjugate	VERB
admet-276	132	20	antibody	antibody	NOUN
admet-276	132	21	)	)	PUNCT
admet-276	132	22	,	,	PUNCT
admet-276	132	23	antibodies	antibodie	VERB
admet-276	132	24	specific	specific	ADJ
admet-276	132	25	for	for	ADP
admet-276	132	26	drugs	drug	NOUN
admet-276	132	27	(	(	PUNCT
admet-276	132	28	total	total	ADJ
admet-276	132	29	antibody	antibody	NOUN
admet-276	132	30	)	)	PUNCT
admet-276	132	31	.	.	PUNCT
admet-276	133	1	biotin	biotin	NOUN
admet-276	133	2	-	-	PUNCT
admet-276	133	3	dig	dig	NOUN
admet-276	133	4	bridging	bridging	NOUN
admet-276	133	5	elisa	elisa	NOUN
admet-276	133	6	and	and	CCONJ
admet-276	133	7	surface	surface	NOUN
admet-276	133	8	plasma	plasma	NOUN
admet-276	133	9	resonance	resonance	NOUN
admet-276	133	10	(	(	PUNCT
admet-276	133	11	spr	spr	ADJ
admet-276	133	12	)	)	PUNCT
admet-276	133	13	techniques	technique	NOUN
admet-276	133	14	were	be	AUX
admet-276	133	15	developed	develop	VERB
admet-276	133	16	for	for	ADP
admet-276	133	17	immunogenicity	immunogenicity	NOUN
admet-276	133	18	assessment	assessment	NOUN
admet-276	133	19	to	to	PART
admet-276	133	20	detect	detect	VERB
admet-276	133	21	anti	anti	ADJ
admet-276	133	22	-	-	ADJ
admet-276	133	23	therapeutic	therapeutic	ADJ
admet-276	133	24	antibodies	antibody	NOUN
admet-276	133	25	(	(	PUNCT
admet-276	133	26	atas	ata	NOUN
admet-276	133	27	)	)	PUNCT
admet-276	133	28	to	to	ADP
admet-276	133	29	the	the	DET
admet-276	133	30	adc	adc	PROPN
admet-276	133	31	,	,	PUNCT
admet-276	133	32	including	include	VERB
admet-276	133	33	atas	ata	NOUN
admet-276	133	34	towards	towards	ADP
admet-276	133	35	any	any	PRON
admet-276	133	36	of	of	ADP
admet-276	133	37	the	the	DET
admet-276	133	38	adc	adc	PROPN
admet-276	133	39	molecular	molecular	ADJ
admet-276	133	40	components	component	NOUN
admet-276	133	41	such	such	ADJ
admet-276	133	42	as	as	ADP
admet-276	133	43	the	the	DET
admet-276	133	44	antibody	antibody	NOUN
admet-276	133	45	,	,	PUNCT
admet-276	133	46	linker	linker	NOUN
admet-276	133	47	,	,	PUNCT
admet-276	133	48	drug	drug	NOUN
admet-276	133	49	or	or	CCONJ
admet-276	133	50	epitopes	epitope	NOUN
admet-276	133	51	involving	involve	VERB
admet-276	133	52	multiple	multiple	ADJ
admet-276	133	53	adc	adc	PROPN
admet-276	133	54	components	component	NOUN
admet-276	133	55	.	.	PUNCT
admet-276	134	1	finally	finally	ADV
admet-276	134	2	,	,	PUNCT
admet-276	134	3	isotope	isotope	NOUN
admet-276	134	4	-	-	PUNCT
admet-276	134	5	labelling	labelling	NOUN
admet-276	134	6	method	method	NOUN
admet-276	134	7	was	be	AUX
admet-276	134	8	used	use	VERB
admet-276	134	9	for	for	ADP
admet-276	134	10	the	the	DET
admet-276	134	11	study	study	NOUN
admet-276	134	12	of	of	ADP
admet-276	134	13	tissue	tissue	NOUN
admet-276	134	14	distribution	distribution	NOUN
admet-276	134	15	and	and	CCONJ
admet-276	134	16	mass	mass	NOUN
admet-276	134	17	balance	balance	NOUN
admet-276	134	18	[	[	X
admet-276	134	19	43,46,54	43,46,54	NUM
admet-276	134	20	]	]	X
admet-276	134	21	.	.	PUNCT
admet-276	135	1	recent	recent	ADJ
admet-276	135	2	advances	advance	NOUN
admet-276	135	3	in	in	ADP
admet-276	135	4	high	high	ADJ
admet-276	135	5	-	-	PUNCT
admet-276	135	6	throughput	throughput	NOUN
admet-276	135	7	formats	format	NOUN
admet-276	135	8	and	and	CCONJ
admet-276	135	9	combined	combined	ADJ
admet-276	135	10	techniques	technique	NOUN
admet-276	135	11	for	for	ADP
admet-276	135	12	adc	adc	NOUN
admet-276	135	13	bioanalysis	bioanalysis	NOUN
admet-276	135	14	will	will	AUX
admet-276	135	15	be	be	AUX
admet-276	135	16	discussed	discuss	VERB
admet-276	135	17	in	in	ADP
admet-276	135	18	more	more	ADJ
admet-276	135	19	details	detail	NOUN
admet-276	135	20	in	in	ADP
admet-276	135	21	the	the	DET
admet-276	135	22	section	section	NOUN
admet-276	135	23	3	3	NUM
admet-276	135	24	.	.	NOUN
admet-276	135	25	2.3	2.3	NUM
admet-276	135	26	.	.	PUNCT
admet-276	136	1	safety	safety	NOUN
admet-276	136	2	evaluation	evaluation	NOUN
admet-276	136	3	of	of	ADP
admet-276	136	4	adcs	adcs	NOUN
admet-276	136	5	with	with	ADP
admet-276	136	6	regard	regard	NOUN
admet-276	136	7	to	to	ADP
admet-276	136	8	preclinical	preclinical	ADJ
admet-276	136	9	safety	safety	NOUN
admet-276	136	10	assessment	assessment	NOUN
admet-276	136	11	,	,	PUNCT
admet-276	136	12	toxicity	toxicity	NOUN
admet-276	136	13	of	of	ADP
admet-276	136	14	adcs	adcs	PROPN
admet-276	136	15	is	be	AUX
admet-276	136	16	usually	usually	ADV
admet-276	136	17	adc	adc	PROPN
admet-276	136	18	/	/	SYM
admet-276	136	19	drug	drug	NOUN
admet-276	136	20	-	-	PUNCT
admet-276	136	21	dependent	dependent	ADJ
admet-276	136	22	and	and	CCONJ
admet-276	136	23	antigen	antigen	NOUN
admet-276	136	24	-	-	PUNCT
admet-276	136	25	independent	independent	ADJ
admet-276	136	26	and	and	CCONJ
admet-276	136	27	it	it	PRON
admet-276	136	28	can	can	AUX
admet-276	136	29	be	be	AUX
admet-276	136	30	more	more	ADV
admet-276	136	31	toxic	toxic	ADJ
admet-276	136	32	than	than	ADP
admet-276	136	33	mabs	mab	NOUN
admet-276	136	34	due	due	ADJ
admet-276	136	35	to	to	ADP
admet-276	136	36	introduced	introduce	VERB
admet-276	136	37	cytotoxic	cytotoxic	ADJ
admet-276	136	38	drugs	drug	NOUN
admet-276	136	39	.	.	PUNCT
admet-276	137	1	as	as	ADP
admet-276	137	2	adcs	adcs	ADJ
admet-276	137	3	consist	consist	NOUN
admet-276	137	4	of	of	ADP
admet-276	137	5	a	a	DET
admet-276	137	6	monoclonal	monoclonal	NOUN
admet-276	137	7	antibody	antibody	NOUN
admet-276	137	8	,	,	PUNCT
admet-276	137	9	linker	linker	NOUN
admet-276	137	10	and	and	CCONJ
admet-276	137	11	cytotoxic	cytotoxic	ADJ
admet-276	137	12	components	component	NOUN
admet-276	137	13	,	,	PUNCT
admet-276	137	14	the	the	DET
admet-276	137	15	biological	biological	ADJ
admet-276	137	16	activity	activity	NOUN
admet-276	137	17	profiles	profile	NOUN
admet-276	137	18	of	of	ADP
admet-276	137	19	each	each	PRON
admet-276	137	20	should	should	AUX
admet-276	137	21	be	be	AUX
admet-276	137	22	considered	consider	VERB
admet-276	137	23	when	when	SCONJ
admet-276	137	24	selecting	select	VERB
admet-276	137	25	the	the	DET
admet-276	137	26	relevant	relevant	ADJ
admet-276	137	27	and/or	and/or	CCONJ
admet-276	137	28	appropriate	appropriate	ADJ
admet-276	137	29	species	specie	NOUN
admet-276	137	30	for	for	ADP
admet-276	137	31	toxicity	toxicity	NOUN
admet-276	137	32	evaluations	evaluation	NOUN
admet-276	137	33	,	,	PUNCT
admet-276	137	34	typically	typically	ADV
admet-276	137	35	in	in	ADP
admet-276	137	36	two	two	NUM
admet-276	137	37	relevant	relevant	ADJ
admet-276	137	38	species	specie	NOUN
admet-276	137	39	(	(	PUNCT
admet-276	137	40	one	one	NUM
admet-276	137	41	rodent	rodent	NOUN
admet-276	137	42	and	and	CCONJ
admet-276	137	43	one	one	NUM
admet-276	137	44	non	non	ADJ
admet-276	137	45	-	-	ADJ
admet-276	137	46	rodent	rodent	ADJ
admet-276	137	47	)	)	PUNCT
admet-276	138	1	[	[	X
admet-276	138	2	55	55	NUM
admet-276	138	3	]	]	PUNCT
admet-276	138	4	.	.	PUNCT
admet-276	139	1	for	for	ADP
admet-276	139	2	a	a	DET
admet-276	139	3	particular	particular	ADJ
admet-276	139	4	adc	adc	NOUN
admet-276	139	5	,	,	PUNCT
admet-276	139	6	the	the	DET
admet-276	139	7	relevant	relevant	ADJ
admet-276	139	8	toxicity	toxicity	NOUN
admet-276	139	9	species	specie	NOUN
admet-276	139	10	should	should	AUX
admet-276	139	11	be	be	AUX
admet-276	139	12	selected	select	VERB
admet-276	139	13	from	from	ADP
admet-276	139	14	its	its	PRON
admet-276	139	15	pharmacology	pharmacology	NOUN
admet-276	139	16	and	and	CCONJ
admet-276	139	17	tissue	tissue	NOUN
admet-276	139	18	-	-	PUNCT
admet-276	139	19	reactivity	reactivity	NOUN
admet-276	139	20	studies	study	NOUN
admet-276	139	21	showing	show	VERB
admet-276	139	22	similar	similar	ADJ
admet-276	139	23	binding	binding	NOUN
admet-276	139	24	to	to	ADP
admet-276	139	25	human	human	NOUN
admet-276	139	26	.	.	PUNCT
admet-276	140	1	primary	primary	ADJ
admet-276	140	2	considerations	consideration	NOUN
admet-276	140	3	for	for	ADP
admet-276	140	4	the	the	DET
admet-276	140	5	nonclinical	nonclinical	ADJ
admet-276	140	6	safety	safety	NOUN
admet-276	140	7	assessment	assessment	NOUN
admet-276	140	8	of	of	ADP
admet-276	140	9	adcs	adcs	PROPN
admet-276	140	10	includes	include	VERB
admet-276	140	11	the	the	DET
admet-276	140	12	evaluation	evaluation	NOUN
admet-276	140	13	of	of	ADP
admet-276	140	14	the	the	DET
admet-276	140	15	entire	entire	ADJ
admet-276	140	16	adc	adc	NOUN
admet-276	140	17	or	or	CCONJ
admet-276	140	18	the	the	DET
admet-276	140	19	various	various	ADJ
admet-276	140	20	individual	individual	ADJ
admet-276	140	21	components	component	NOUN
admet-276	140	22	(	(	PUNCT
admet-276	140	23	i.e.	i.e.	X
admet-276	140	24	,	,	PUNCT
admet-276	140	25	antibody	antibody	NOUN
admet-276	140	26	,	,	PUNCT
admet-276	140	27	linker	linker	NOUN
admet-276	140	28	or	or	CCONJ
admet-276	140	29	the	the	DET
admet-276	140	30	cytotoxin	cytotoxin	NOUN
admet-276	140	31	)	)	PUNCT
admet-276	140	32	to	to	PART
admet-276	140	33	identify	identify	VERB
admet-276	140	34	the	the	DET
admet-276	140	35	onand	onand	NOUN
admet-276	140	36	off	off	ADP
admet-276	140	37	-	-	PUNCT
admet-276	140	38	target	target	NOUN
admet-276	140	39	toxicities	toxicity	NOUN
admet-276	140	40	to	to	PART
admet-276	140	41	enable	enable	VERB
admet-276	140	42	first	first	ADJ
admet-276	140	43	-	-	PUNCT
admet-276	140	44	in	in	ADP
admet-276	140	45	-	-	PUNCT
admet-276	140	46	human	human	ADJ
admet-276	140	47	(	(	PUNCT
admet-276	140	48	fih	fih	NOUN
admet-276	140	49	)	)	PUNCT
admet-276	140	50	studies	study	NOUN
admet-276	140	51	[	[	X
admet-276	140	52	41	41	NUM
admet-276	140	53	]	]	PUNCT
admet-276	140	54	.	.	PUNCT
admet-276	141	1	general	general	ADJ
admet-276	141	2	toxicity	toxicity	NOUN
admet-276	141	3	studies	study	NOUN
admet-276	141	4	are	be	AUX
admet-276	141	5	recommended	recommend	VERB
admet-276	141	6	and	and	CCONJ
admet-276	141	7	following	follow	VERB
admet-276	141	8	specific	specific	ADJ
admet-276	141	9	toxicity	toxicity	NOUN
admet-276	141	10	studies	study	NOUN
admet-276	141	11	may	may	AUX
admet-276	141	12	be	be	AUX
admet-276	141	13	considered	consider	VERB
admet-276	141	14	as	as	ADV
admet-276	141	15	well	well	ADV
admet-276	141	16	for	for	ADP
admet-276	141	17	overall	overall	ADJ
admet-276	141	18	nonclinical	nonclinical	ADJ
admet-276	141	19	safety	safety	NOUN
admet-276	141	20	evaluations	evaluation	NOUN
admet-276	141	21	[	[	X
admet-276	141	22	25,35,41,42,56,57	25,35,41,42,56,57	NUM
admet-276	141	23	]	]	PUNCT
admet-276	141	24	:	:	PUNCT
admet-276	141	25			NOUN
admet-276	141	26	acute	acute	ADJ
admet-276	141	27	and	and	CCONJ
admet-276	141	28	chronic	chronic	ADJ
admet-276	141	29	toxicity	toxicity	NOUN
admet-276	141	30	study	study	NOUN
admet-276	141	31	on	on	ADP
admet-276	141	32	two	two	NUM
admet-276	141	33	relevant	relevant	ADJ
admet-276	141	34	species	specie	NOUN
admet-276	141	35	(	(	PUNCT
admet-276	141	36	preferably	preferably	ADV
admet-276	141	37	rodent	rodent	VERB
admet-276	141	38	and	and	CCONJ
admet-276	141	39	non	non	ADJ
admet-276	141	40	-	-	ADJ
admet-276	141	41	rodent	rodent	ADJ
admet-276	141	42	)	)	PUNCT
admet-276	141	43	,	,	PUNCT
admet-276	141	44	or	or	CCONJ
admet-276	141	45	transgenic	transgenic	NOUN
admet-276	141	46	animals	animal	NOUN
admet-276	141	47	(	(	PUNCT
admet-276	141	48	i.e.	i.e.	X
admet-276	141	49	,	,	PUNCT
admet-276	141	50	animal	animal	NOUN
admet-276	141	51	modified	modify	VERB
admet-276	141	52	to	to	ADP
admet-276	141	53	the	the	DET
admet-276	141	54	human	human	ADJ
admet-276	141	55	target	target	NOUN
admet-276	141	56	)	)	PUNCT
admet-276	141	57	to	to	PART
admet-276	141	58	attain	attain	VERB
admet-276	141	59	maximum	maximum	ADJ
admet-276	141	60	tolerated	tolerate	VERB
admet-276	141	61	dose	dose	PROPN
admet-276	141	62	(	(	PUNCT
admet-276	141	63	mtd	mtd	PROPN
admet-276	141	64	)	)	PUNCT
admet-276	141	65	,	,	PUNCT
admet-276	141	66	non	non	ADJ
admet-276	141	67	-	-	ADJ
admet-276	141	68	observed	observed	ADJ
admet-276	141	69	adverse	adverse	ADJ
admet-276	141	70	effect	effect	NOUN
admet-276	141	71	level	level	NOUN
admet-276	141	72	(	(	PUNCT
admet-276	141	73	noael	noael	NUM
admet-276	141	74	)	)	PUNCT
admet-276	141	75	or	or	CCONJ
admet-276	141	76	the	the	DET
admet-276	141	77	highest	high	ADJ
admet-276	141	78	non	non	ADJ
admet-276	141	79	-	-	ADJ
admet-276	141	80	severely	severely	ADV
admet-276	141	81	toxic	toxic	ADJ
admet-276	141	82	dose	dose	NOUN
admet-276	141	83	(	(	PUNCT
admet-276	141	84	hnstd	hnstd	PROPN
admet-276	141	85	)	)	PUNCT
admet-276	141	86	.	.	PUNCT
admet-276	142	1			NOUN
admet-276	142	2	tissue	tissue	NOUN
admet-276	142	3	cross	cross	NOUN
admet-276	142	4	-	-	NOUN
admet-276	142	5	reactivity	reactivity	ADJ
admet-276	142	6	(	(	PUNCT
admet-276	142	7	tcr	tcr	PROPN
admet-276	142	8	)	)	PUNCT
admet-276	142	9	in	in	ADP
admet-276	142	10	tissue	tissue	NOUN
admet-276	142	11	panels	panel	NOUN
admet-276	142	12	from	from	ADP
admet-276	142	13	humans	human	NOUN
admet-276	142	14	and	and	CCONJ
admet-276	142	15	toxicity	toxicity	NOUN
admet-276	142	16	species	specie	NOUN
admet-276	142	17	for	for	ADP
admet-276	142	18	adc	adc	PROPN
admet-276	142	19	and	and	CCONJ
admet-276	142	20	unconjugated	unconjugated	ADJ
admet-276	142	21	antibody	antibody	NOUN
admet-276	142	22			NOUN
admet-276	142	23	genotoxicity	genotoxicity	NOUN
admet-276	142	24	of	of	ADP
admet-276	142	25	cytotoxin	cytotoxin	NOUN
admet-276	142	26	and/or	and/or	CCONJ
admet-276	142	27	linker	linker	NOUN
admet-276	142	28	,	,	PUNCT
admet-276	142	29	and	and	CCONJ
admet-276	142	30	adc	adc	PROPN
admet-276	142	31	may	may	AUX
admet-276	142	32	be	be	AUX
admet-276	142	33	concerned	concern	VERB
admet-276	142	34			PROPN
admet-276	142	35	herg	herg	PROPN
admet-276	142	36	for	for	ADP
admet-276	142	37	unconjugated	unconjugated	ADJ
admet-276	142	38	drug	drug	NOUN
admet-276	142	39	if	if	SCONJ
admet-276	142	40	concentration	concentration	NOUN
admet-276	142	41	of	of	ADP
admet-276	142	42	the	the	DET
admet-276	142	43	unconjugated	unconjugated	ADJ
admet-276	142	44	cytotoxin	cytotoxin	NOUN
admet-276	142	45	are	be	AUX
admet-276	142	46	detected	detect	VERB
admet-276	142	47	in	in	ADP
admet-276	142	48	the	the	DET
admet-276	142	49	serum	serum	NOUN
admet-276	142	50	during	during	ADP
admet-276	142	51	toxicity	toxicity	NOUN
admet-276	142	52	and	and	CCONJ
admet-276	142	53	plasma	plasma	NOUN
admet-276	142	54	stability	stability	NOUN
admet-276	142	55	testing	test	VERB
admet-276	142	56			PROPN
admet-276	142	57	reproductive	reproductive	ADJ
admet-276	142	58	and	and	CCONJ
admet-276	142	59	developmental	developmental	ADJ
admet-276	142	60	toxicity	toxicity	NOUN
admet-276	142	61	for	for	ADP
admet-276	142	62	embryofetal	embryofetal	ADJ
admet-276	142	63	(	(	PUNCT
admet-276	142	64	efd	efd	PROPN
admet-276	142	65	)	)	PUNCT
admet-276	142	66	toxicity	toxicity	NOUN
admet-276	142	67	assessment	assessment	NOUN
admet-276	142	68	of	of	ADP
admet-276	142	69	adc	adc	PROPN
admet-276	142	70	and	and	CCONJ
admet-276	142	71	unconjugated	unconjugated	ADJ
admet-276	142	72	toxin	toxin	NOUN
admet-276	142	73			NOUN
admet-276	142	74	carcinogenicity	carcinogenicity	NOUN
admet-276	142	75			NOUN
admet-276	142	76	immunogenicity	immunogenicity	NOUN
admet-276	142	77	and	and	CCONJ
admet-276	142	78	anti	anti	ADJ
admet-276	142	79	-	-	ADJ
admet-276	142	80	adc	adc	ADJ
admet-276	142	81	antibody	antibody	NOUN
admet-276	142	82			NOUN
admet-276	142	83	cyp	cyp	ADJ
admet-276	142	84	inhibition	inhibition	NOUN
admet-276	142	85	and	and	CCONJ
admet-276	142	86	induction	induction	NOUN
admet-276	142	87	for	for	ADP
admet-276	142	88	ddi	ddi	PROPN
admet-276	142	89	assessment	assessment	NOUN
admet-276	142	90			NOUN
admet-276	142	91	hemolysis	hemolysis	NOUN
admet-276	142	92	,	,	PUNCT
admet-276	142	93	skin	skin	NOUN
admet-276	142	94	irritation	irritation	NOUN
admet-276	142	95	and	and	CCONJ
admet-276	142	96	sensitization	sensitization	NOUN
admet-276	142	97	testing	testing	NOUN
admet-276	142	98	for	for	ADP
admet-276	142	99	biologics	biologic	NOUN
admet-276	142	100	via	via	ADP
admet-276	142	101	injection	injection	NOUN
admet-276	142	102	administration	administration	NOUN
admet-276	142	103	.	.	PUNCT
admet-276	143	1	another	another	DET
admet-276	143	2	important	important	ADJ
admet-276	143	3	consideration	consideration	NOUN
admet-276	143	4	would	would	AUX
admet-276	143	5	be	be	AUX
admet-276	143	6	the	the	DET
admet-276	143	7	concentrations	concentration	NOUN
admet-276	143	8	of	of	ADP
admet-276	143	9	unreacted	unreacted	ADJ
admet-276	143	10	linker	linker	NOUN
admet-276	143	11	that	that	PRON
admet-276	143	12	remain	remain	VERB
admet-276	143	13	in	in	ADP
admet-276	143	14	the	the	DET
admet-276	143	15	final	final	ADJ
admet-276	143	16	drug	drug	NOUN
admet-276	143	17	product	product	NOUN
admet-276	143	18	.	.	PUNCT
admet-276	144	1	if	if	SCONJ
admet-276	144	2	the	the	DET
admet-276	144	3	cytotoxin	cytotoxin	NOUN
admet-276	144	4	is	be	AUX
admet-276	144	5	a	a	DET
admet-276	144	6	novel	novel	ADJ
admet-276	144	7	chemical	chemical	NOUN
admet-276	144	8	entity	entity	NOUN
admet-276	144	9	,	,	PUNCT
admet-276	144	10	then	then	ADV
admet-276	144	11	a	a	DET
admet-276	144	12	more	more	ADV
admet-276	144	13	detailed	detailed	ADJ
admet-276	144	14	assessment	assessment	NOUN
admet-276	144	15	of	of	ADP
admet-276	144	16	metabolism	metabolism	NOUN
admet-276	144	17	and	and	CCONJ
admet-276	144	18	disposition	disposition	NOUN
admet-276	144	19	(	(	PUNCT
admet-276	144	20	including	include	VERB
admet-276	144	21	pk	pk	NOUN
admet-276	144	22	/	/	SYM
admet-276	144	23	adme	adme	NOUN
admet-276	144	24	studies	study	NOUN
admet-276	144	25	)	)	PUNCT
admet-276	144	26	may	may	AUX
admet-276	144	27	be	be	AUX
admet-276	144	28	necessary	necessary	ADJ
admet-276	144	29	as	as	SCONJ
admet-276	144	30	the	the	DET
admet-276	144	31	cytotoxic	cytotoxic	ADJ
admet-276	144	32	drug	drug	NOUN
admet-276	144	33	released	release	VERB
admet-276	144	34	from	from	ADP
admet-276	144	35	the	the	DET
admet-276	144	36	adc	adc	NOUN
admet-276	144	37	may	may	AUX
admet-276	144	38	be	be	AUX
admet-276	144	39	associated	associate	VERB
admet-276	144	40	with	with	ADP
admet-276	144	41	loss	loss	NOUN
admet-276	144	42	of	of	ADP
admet-276	144	43	efficacy	efficacy	NOUN
admet-276	144	44	or	or	CCONJ
admet-276	144	45	increased	increase	VERB
admet-276	144	46	toxicity	toxicity	NOUN
admet-276	144	47	.	.	PUNCT
admet-276	145	1	however	however	ADV
admet-276	145	2	,	,	PUNCT
admet-276	145	3	if	if	SCONJ
admet-276	145	4	the	the	DET
admet-276	145	5	concentrations	concentration	NOUN
admet-276	145	6	of	of	ADP
admet-276	145	7	unconjugated	unconjugated	ADJ
admet-276	145	8	cytotoxin	cytotoxin	NOUN
admet-276	145	9	in	in	ADP
admet-276	145	10	plasma	plasma	NOUN
admet-276	145	11	are	be	AUX
admet-276	145	12	very	very	ADV
admet-276	145	13	low	low	ADJ
admet-276	145	14	,	,	PUNCT
admet-276	145	15	for	for	ADP
admet-276	145	16	instance	instance	NOUN
admet-276	145	17	,	,	PUNCT
admet-276	145	18	the	the	DET
admet-276	145	19	free	free	ADJ
admet-276	145	20	dm1	dm1	NOUN
admet-276	145	21	after	after	ADP
admet-276	145	22	administrating	administrate	VERB
admet-276	145	23	the	the	DET
admet-276	145	24	trastuzumab	trastuzumab	NOUN
admet-276	145	25	emtansine	emtansine	NOUN
admet-276	145	26	(	(	PUNCT
admet-276	145	27	t	t	PROPN
admet-276	145	28	-	-	PUNCT
admet-276	145	29	dm1	dm1	NOUN
admet-276	145	30	)	)	PUNCT
admet-276	145	31	was	be	AUX
admet-276	145	32	<	<	X
admet-276	145	33	10	10	NUM
admet-276	145	34	ng	ng	PROPN
admet-276	145	35	/	/	SYM
admet-276	145	36	ml	ml	PROPN
admet-276	145	37	(	(	PUNCT
admet-276	145	38	<	<	X
admet-276	145	39	10	10	NUM
admet-276	145	40	nm	nm	NOUN
admet-276	145	41	)	)	PUNCT
admet-276	145	42	at	at	ADP
admet-276	145	43	all	all	DET
admet-276	145	44	doses	dose	NOUN
admet-276	145	45	[	[	X
admet-276	145	46	53	53	NUM
admet-276	145	47	]	]	PUNCT
admet-276	145	48	,	,	PUNCT
admet-276	145	49	or	or	CCONJ
admet-276	145	50	maximal	maximal	ADJ
admet-276	145	51	dm1	dm1	NOUN
admet-276	145	52	concentration	concentration	NOUN
admet-276	145	53	did	do	AUX
admet-276	145	54	not	not	PART
admet-276	145	55	exceed	exceed	VERB
admet-276	145	56	25	25	NUM
admet-276	145	57	ng	ng	NOUN
admet-276	145	58	/	/	SYM
admet-276	145	59	ml	ml	NOUN
admet-276	145	60	after	after	ADP
admet-276	145	61	repeated	repeat	VERB
admet-276	145	62	dosing	dosing	NOUN
admet-276	145	63	of	of	ADP
admet-276	145	64	t	t	PROPN
admet-276	145	65	-	-	PUNCT
admet-276	145	66	dm1	dm1	NOUN
admet-276	146	1	[	[	X
admet-276	146	2	58	58	NUM
admet-276	146	3	]	]	PUNCT
admet-276	146	4	,	,	PUNCT
admet-276	146	5	the	the	DET
admet-276	146	6	investigation	investigation	NOUN
admet-276	146	7	of	of	ADP
admet-276	146	8	inhibition	inhibition	NOUN
admet-276	146	9	or	or	CCONJ
admet-276	146	10	induction	induction	NOUN
admet-276	146	11	of	of	ADP
admet-276	146	12	admet	admet	PROPN
admet-276	146	13	&	&	CCONJ
admet-276	146	14	dmpk	dmpk	PROPN
admet-276	146	15	4(1	4(1	NOUN
admet-276	146	16	)	)	PUNCT
admet-276	146	17	(	(	PUNCT
admet-276	146	18	2016	2016	NUM
admet-276	146	19	)	)	PUNCT
admet-276	146	20	1	1	NUM
admet-276	146	21	-	-	SYM
admet-276	146	22	22	22	NUM
admet-276	146	23	adme	adme	NOUN
admet-276	146	24	testing	testing	NOUN
admet-276	146	25	of	of	ADP
admet-276	146	26	large	large	ADJ
admet-276	146	27	biologics	biologic	NOUN
admet-276	146	28	doi	doi	NOUN
admet-276	146	29	:	:	PUNCT
admet-276	146	30	10.5599	10.5599	NUM
admet-276	146	31	/	/	SYM
admet-276	146	32	admet.4.1.276	admet.4.1.276	NUM
admet-276	146	33	9	9	NUM
admet-276	146	34	cyp	cyp	ADJ
admet-276	146	35	isoenzymes	isoenzyme	NOUN
admet-276	146	36	to	to	PART
admet-276	146	37	assess	assess	VERB
admet-276	146	38	the	the	DET
admet-276	146	39	potential	potential	ADJ
admet-276	146	40	ddi	ddi	NOUN
admet-276	146	41	should	should	AUX
admet-276	146	42	not	not	PART
admet-276	146	43	be	be	AUX
admet-276	146	44	necessary	necessary	ADJ
admet-276	146	45	in	in	ADP
admet-276	146	46	this	this	DET
admet-276	146	47	case	case	NOUN
admet-276	146	48	[	[	X
admet-276	146	49	41	41	NUM
admet-276	146	50	]	]	PUNCT
admet-276	146	51	.	.	PUNCT
admet-276	147	1	in	in	ADP
admet-276	147	2	other	other	ADJ
admet-276	147	3	words	word	NOUN
admet-276	147	4	,	,	PUNCT
admet-276	147	5	the	the	DET
admet-276	147	6	risk	risk	NOUN
admet-276	147	7	of	of	ADP
admet-276	147	8	ddi	ddi	PROPN
admet-276	147	9	is	be	AUX
admet-276	147	10	presumably	presumably	ADV
admet-276	147	11	low	low	ADJ
admet-276	147	12	due	due	ADP
admet-276	147	13	to	to	ADP
admet-276	147	14	very	very	ADV
admet-276	147	15	low	low	ADJ
admet-276	147	16	concentrations	concentration	NOUN
admet-276	147	17	of	of	ADP
admet-276	147	18	cytotoxic	cytotoxic	ADJ
admet-276	147	19	drug	drug	NOUN
admet-276	147	20	released	release	VERB
admet-276	147	21	from	from	ADP
admet-276	147	22	adcs	adc	NOUN
admet-276	147	23	.	.	PUNCT
admet-276	148	1	despite	despite	SCONJ
admet-276	148	2	this	this	DET
admet-276	148	3	hypothesis	hypothesis	NOUN
admet-276	148	4	,	,	PUNCT
admet-276	148	5	cyp3a4	cyp3a4	NOUN
admet-276	148	6	based	base	VERB
admet-276	148	7	inhibition	inhibition	NOUN
admet-276	148	8	studies	study	NOUN
admet-276	148	9	for	for	ADP
admet-276	148	10	kadcyla	kadcyla	NOUN
admet-276	148	11	and	and	CCONJ
admet-276	148	12	decetris	decetris	NOUN
admet-276	148	13	have	have	AUX
admet-276	148	14	been	be	AUX
admet-276	148	15	conducted	conduct	VERB
admet-276	148	16	,	,	PUNCT
admet-276	148	17	respectively	respectively	ADV
admet-276	148	18	,	,	PUNCT
admet-276	148	19	as	as	SCONJ
admet-276	148	20	the	the	DET
admet-276	148	21	sgn-35	sgn-35	ADV
admet-276	148	22	is	be	AUX
admet-276	148	23	metabolized	metabolize	VERB
admet-276	148	24	with	with	ADP
admet-276	148	25	a	a	DET
admet-276	148	26	small	small	ADJ
admet-276	148	27	fraction	fraction	NOUN
admet-276	148	28	of	of	ADP
admet-276	148	29	mmae	mmae	NOUN
admet-276	148	30	via	via	ADP
admet-276	148	31	oxidation	oxidation	NOUN
admet-276	148	32	by	by	ADP
admet-276	148	33	primarily	primarily	ADV
admet-276	148	34	cyp3a4	cyp3a4	NOUN
admet-276	148	35	and	and	CCONJ
admet-276	148	36	cyp3a5	cyp3a5	NOUN
admet-276	148	37	,	,	PUNCT
admet-276	148	38	and	and	CCONJ
admet-276	148	39	kadcyla	kadcyla	NOUN
admet-276	148	40	(	(	PUNCT
admet-276	148	41	t	t	PROPN
admet-276	148	42	-	-	PUNCT
admet-276	148	43	dm1	dm1	NOUN
admet-276	148	44	)	)	PUNCT
admet-276	148	45	mainly	mainly	ADV
admet-276	148	46	by	by	ADP
admet-276	148	47	cyp3a4	cyp3a4	NOUN
admet-276	148	48	and	and	CCONJ
admet-276	148	49	a	a	DET
admet-276	148	50	lesser	less	ADJ
admet-276	148	51	extent	extent	NOUN
admet-276	148	52	by	by	ADP
admet-276	148	53	cyp3a5	cyp3a5	NOUN
admet-276	148	54	.	.	PUNCT
admet-276	149	1	nevertheless	nevertheless	ADV
admet-276	149	2	,	,	PUNCT
admet-276	149	3	an	an	DET
admet-276	149	4	in	in	ADP
admet-276	149	5	vitro	vitro	X
admet-276	149	6	stability	stability	NOUN
admet-276	149	7	of	of	ADP
admet-276	149	8	adcs	adcs	NOUN
admet-276	149	9	in	in	ADP
admet-276	149	10	plasma	plasma	NOUN
admet-276	149	11	and	and	CCONJ
admet-276	149	12	in	in	ADP
admet-276	149	13	vivo	vivo	ADJ
admet-276	149	14	monitoring	monitoring	NOUN
admet-276	149	15	toxin	toxin	NOUN
admet-276	149	16	released	release	VERB
admet-276	149	17	from	from	ADP
admet-276	149	18	adc	adc	PROPN
admet-276	149	19	should	should	AUX
admet-276	149	20	be	be	AUX
admet-276	149	21	conducted	conduct	VERB
admet-276	149	22	to	to	PART
admet-276	149	23	ensure	ensure	VERB
admet-276	149	24	the	the	DET
admet-276	149	25	cytotoxic	cytotoxic	ADJ
admet-276	149	26	drug	drug	NOUN
admet-276	149	27	or	or	CCONJ
admet-276	149	28	potential	potential	ADJ
admet-276	149	29	catabolites	catabolite	NOUN
admet-276	149	30	under	under	ADP
admet-276	149	31	the	the	DET
admet-276	149	32	minimal	minimal	ADJ
admet-276	149	33	level	level	NOUN
admet-276	149	34	as	as	ADP
admet-276	149	35	such	such	ADJ
admet-276	149	36	without	without	ADP
admet-276	149	37	safety	safety	NOUN
admet-276	149	38	issues	issue	NOUN
admet-276	149	39	,	,	PUNCT
admet-276	149	40	in	in	ADP
admet-276	149	41	particular	particular	ADJ
admet-276	149	42	for	for	ADP
admet-276	149	43	major	major	ADJ
admet-276	149	44	cyp	cyp	ADJ
admet-276	149	45	metabolism	metabolism	NOUN
admet-276	149	46	involved	involve	VERB
admet-276	149	47	adc	adc	PROPN
admet-276	149	48	drugs	drug	NOUN
admet-276	149	49	.	.	PUNCT
admet-276	150	1	on	on	ADP
admet-276	150	2	the	the	DET
admet-276	150	3	other	other	ADJ
admet-276	150	4	hand	hand	NOUN
admet-276	150	5	,	,	PUNCT
admet-276	150	6	a	a	DET
admet-276	150	7	typical	typical	ADJ
admet-276	150	8	adc	adc	PROPN
admet-276	150	9	consists	consist	VERB
admet-276	150	10	of	of	ADP
admet-276	150	11	a	a	DET
admet-276	150	12	distribution	distribution	NOUN
admet-276	150	13	of	of	ADP
admet-276	150	14	several	several	ADJ
admet-276	150	15	entities	entity	NOUN
admet-276	150	16	containing	contain	VERB
admet-276	150	17	different	different	ADJ
admet-276	150	18	numbers	number	NOUN
admet-276	150	19	of	of	ADP
admet-276	150	20	cytotoxic	cytotoxic	ADJ
admet-276	150	21	drugs	drug	NOUN
admet-276	150	22	on	on	ADP
admet-276	150	23	antibody	antibody	NOUN
admet-276	150	24	,	,	PUNCT
admet-276	150	25	linked	link	VERB
admet-276	150	26	at	at	ADP
admet-276	150	27	different	different	ADJ
admet-276	150	28	positions	position	NOUN
admet-276	150	29	,	,	PUNCT
admet-276	150	30	thus	thus	ADV
admet-276	150	31	,	,	PUNCT
admet-276	150	32	the	the	DET
admet-276	150	33	inherent	inherent	ADJ
admet-276	150	34	heterogeneity	heterogeneity	NOUN
admet-276	150	35	of	of	ADP
admet-276	150	36	adc	adc	PROPN
admet-276	150	37	complex	complex	NOUN
admet-276	150	38	with	with	ADP
admet-276	150	39	multiple	multiple	ADJ
admet-276	150	40	components	component	NOUN
admet-276	150	41	still	still	ADV
admet-276	150	42	remains	remain	VERB
admet-276	150	43	a	a	DET
admet-276	150	44	prominent	prominent	ADJ
admet-276	150	45	challenge	challenge	NOUN
admet-276	150	46	in	in	ADP
admet-276	150	47	understanding	understand	VERB
admet-276	150	48	their	their	PRON
admet-276	150	49	properties	property	NOUN
admet-276	150	50	in	in	ADP
admet-276	150	51	vivo	vivo	NOUN
admet-276	150	52	during	during	ADP
admet-276	150	53	nonclinical	nonclinical	ADJ
admet-276	150	54	development	development	NOUN
admet-276	150	55	.	.	PUNCT
admet-276	151	1	for	for	ADP
admet-276	151	2	instance	instance	NOUN
admet-276	151	3	,	,	PUNCT
admet-276	151	4	conjugation	conjugation	NOUN
admet-276	151	5	through	through	ADP
admet-276	151	6	interchain	interchain	ADJ
admet-276	151	7	disulfides	disulfide	NOUN
admet-276	151	8	can	can	AUX
admet-276	151	9	lead	lead	VERB
admet-276	151	10	to	to	ADP
admet-276	151	11	these	these	DET
admet-276	151	12	adcs	adcs	ADJ
admet-276	151	13	with	with	ADP
admet-276	151	14	dar	dar	NOUN
admet-276	151	15	distribution	distribution	NOUN
admet-276	151	16	ranging	range	VERB
admet-276	151	17	from	from	ADP
admet-276	151	18	0	0	NUM
admet-276	151	19	to	to	ADP
admet-276	151	20	8	8	NUM
admet-276	151	21	,	,	PUNCT
admet-276	151	22	with	with	ADP
admet-276	151	23	each	each	DET
admet-276	151	24	fraction	fraction	NOUN
admet-276	151	25	potentially	potentially	ADV
admet-276	151	26	exhibiting	exhibit	VERB
admet-276	151	27	a	a	DET
admet-276	151	28	unique	unique	ADJ
admet-276	151	29	efficacy	efficacy	NOUN
admet-276	151	30	,	,	PUNCT
admet-276	151	31	pk	pk	NOUN
admet-276	151	32	property	property	NOUN
admet-276	151	33	,	,	PUNCT
admet-276	151	34	and	and	CCONJ
admet-276	151	35	toxicity	toxicity	NOUN
admet-276	151	36	profile	profile	NOUN
admet-276	151	37	[	[	X
admet-276	151	38	43	43	NUM
admet-276	151	39	]	]	PUNCT
admet-276	151	40	.	.	PUNCT
admet-276	152	1	therefore	therefore	ADV
admet-276	152	2	,	,	PUNCT
admet-276	152	3	development	development	NOUN
admet-276	152	4	of	of	ADP
admet-276	152	5	more	more	ADV
admet-276	152	6	sensitive	sensitive	ADJ
admet-276	152	7	and	and	CCONJ
admet-276	152	8	specific	specific	ADJ
admet-276	152	9	bioanalytical	bioanalytical	ADJ
admet-276	152	10	methods	method	NOUN
admet-276	152	11	to	to	PART
admet-276	152	12	differentiate	differentiate	VERB
admet-276	152	13	a	a	DET
admet-276	152	14	single	single	ADJ
admet-276	152	15	adc	adc	NOUN
admet-276	152	16	and	and	CCONJ
admet-276	152	17	multiple	multiple	ADJ
admet-276	152	18	adcs	adcs	ADJ
admet-276	152	19	would	would	AUX
admet-276	152	20	be	be	AUX
admet-276	152	21	highly	highly	ADV
admet-276	152	22	valuable	valuable	ADJ
admet-276	152	23	to	to	PART
admet-276	152	24	enable	enable	VERB
admet-276	152	25	quantifying	quantify	VERB
admet-276	152	26	adc	adc	PROPN
admet-276	152	27	complex	complex	NOUN
admet-276	152	28	for	for	ADP
admet-276	152	29	a	a	DET
admet-276	152	30	better	well	ADJ
admet-276	152	31	understanding	understanding	NOUN
admet-276	152	32	of	of	ADP
admet-276	152	33	attributes	attribute	NOUN
admet-276	152	34	of	of	ADP
admet-276	152	35	each	each	DET
admet-276	152	36	single	single	ADJ
admet-276	152	37	adc	adc	PROPN
admet-276	152	38	component	component	NOUN
admet-276	152	39	to	to	ADP
admet-276	152	40	pk	pk	NOUN
admet-276	152	41	and	and	CCONJ
admet-276	152	42	pd	pd	PROPN
admet-276	152	43	as	as	ADV
admet-276	152	44	well	well	ADV
admet-276	152	45	as	as	ADP
admet-276	152	46	safety	safety	NOUN
admet-276	152	47	profiles	profile	NOUN
admet-276	152	48	.	.	PUNCT
admet-276	153	1	although	although	SCONJ
admet-276	153	2	it	it	PRON
admet-276	153	3	would	would	AUX
admet-276	153	4	be	be	AUX
admet-276	153	5	ideal	ideal	ADJ
admet-276	153	6	to	to	PART
admet-276	153	7	monitor	monitor	VERB
admet-276	153	8	each	each	DET
admet-276	153	9	individual	individual	ADJ
admet-276	153	10	adc	adc	PROPN
admet-276	153	11	species	specie	NOUN
admet-276	153	12	of	of	ADP
admet-276	153	13	a	a	DET
admet-276	153	14	specific	specific	ADJ
admet-276	153	15	dar	dar	NOUN
admet-276	153	16	,	,	PUNCT
admet-276	153	17	this	this	PRON
admet-276	153	18	currently	currently	ADV
admet-276	153	19	seems	seem	VERB
admet-276	153	20	to	to	PART
admet-276	153	21	be	be	AUX
admet-276	153	22	a	a	DET
admet-276	153	23	technical	technical	ADJ
admet-276	153	24	challenge	challenge	NOUN
admet-276	153	25	.	.	PUNCT
admet-276	154	1	therefore	therefore	ADV
admet-276	154	2	,	,	PUNCT
admet-276	154	3	the	the	DET
admet-276	154	4	most	most	ADV
admet-276	154	5	common	common	ADJ
admet-276	154	6	approach	approach	NOUN
admet-276	154	7	is	be	AUX
admet-276	154	8	to	to	PART
admet-276	154	9	monitor	monitor	VERB
admet-276	154	10	all	all	DET
admet-276	154	11	adc	adc	PROPN
admet-276	154	12	species	specie	NOUN
admet-276	154	13	,	,	PUNCT
admet-276	154	14	all	all	DET
admet-276	154	15	antibody	antibody	NOUN
admet-276	154	16	species	specie	NOUN
admet-276	154	17	or	or	CCONJ
admet-276	154	18	total	total	ADJ
admet-276	154	19	antibody	antibody	NOUN
admet-276	154	20	(	(	PUNCT
admet-276	154	21	tab	tab	NOUN
admet-276	154	22	)	)	PUNCT
admet-276	154	23	,	,	PUNCT
admet-276	154	24	and	and	CCONJ
admet-276	154	25	the	the	DET
admet-276	154	26	unconjugated	unconjugated	ADJ
admet-276	154	27	small	small	ADJ
admet-276	154	28	molecule	molecule	NOUN
admet-276	154	29	.	.	PUNCT
admet-276	155	1	an	an	DET
admet-276	155	2	alternative	alternative	ADJ
admet-276	155	3	approach	approach	NOUN
admet-276	155	4	is	be	AUX
admet-276	155	5	to	to	PART
admet-276	155	6	monitor	monitor	VERB
admet-276	155	7	conjugated	conjugate	VERB
admet-276	155	8	small	small	ADJ
admet-276	155	9	molecules	molecule	NOUN
admet-276	155	10	as	as	ADP
admet-276	155	11	a	a	DET
admet-276	155	12	surrogate	surrogate	NOUN
admet-276	155	13	for	for	ADP
admet-276	155	14	adc	adc	NOUN
admet-276	156	1	[	[	X
admet-276	156	2	9	9	NUM
admet-276	156	3	]	]	PUNCT
admet-276	156	4	.	.	PUNCT
admet-276	157	1	overall	overall	ADV
admet-276	157	2	,	,	PUNCT
admet-276	157	3	a	a	DET
admet-276	157	4	design	design	NOUN
admet-276	157	5	goal	goal	NOUN
admet-276	157	6	of	of	ADP
admet-276	157	7	an	an	DET
admet-276	157	8	adc	adc	NOUN
admet-276	157	9	is	be	AUX
admet-276	157	10	to	to	PART
admet-276	157	11	maximize	maximize	VERB
admet-276	157	12	delivery	delivery	NOUN
admet-276	157	13	of	of	ADP
admet-276	157	14	the	the	DET
admet-276	157	15	cell	cell	NOUN
admet-276	157	16	-	-	PUNCT
admet-276	157	17	killing	kill	VERB
admet-276	157	18	agent	agent	NOUN
admet-276	157	19	to	to	ADP
admet-276	157	20	the	the	DET
admet-276	157	21	tumor	tumor	NOUN
admet-276	157	22	tissue	tissue	NOUN
admet-276	157	23	while	while	SCONJ
admet-276	157	24	minimizing	minimize	VERB
admet-276	157	25	delivery	delivery	NOUN
admet-276	157	26	to	to	ADP
admet-276	157	27	normal	normal	ADJ
admet-276	157	28	tissues	tissue	NOUN
admet-276	157	29	[	[	X
admet-276	157	30	54	54	NUM
admet-276	157	31	]	]	PUNCT
admet-276	157	32	.	.	PUNCT
admet-276	158	1	the	the	DET
admet-276	158	2	choices	choice	NOUN
admet-276	158	3	of	of	ADP
admet-276	158	4	mabs	mab	NOUN
admet-276	158	5	,	,	PUNCT
admet-276	158	6	linker	linker	NOUN
admet-276	158	7	,	,	PUNCT
admet-276	158	8	toxin	toxin	NOUN
admet-276	158	9	or	or	CCONJ
admet-276	158	10	cytotoxic	cytotoxic	ADJ
admet-276	158	11	drug	drug	NOUN
admet-276	158	12	are	be	AUX
admet-276	158	13	all	all	PRON
admet-276	158	14	important	important	ADJ
admet-276	158	15	determinants	determinant	NOUN
admet-276	158	16	of	of	ADP
admet-276	158	17	pk	pk	NOUN
admet-276	158	18	,	,	PUNCT
admet-276	158	19	efficacy	efficacy	NOUN
admet-276	158	20	and	and	CCONJ
admet-276	158	21	safety	safety	NOUN
admet-276	158	22	.	.	PUNCT
admet-276	159	1	as	as	ADP
admet-276	159	2	a	a	DET
admet-276	159	3	result	result	NOUN
admet-276	159	4	,	,	PUNCT
admet-276	159	5	design	design	NOUN
admet-276	159	6	and	and	CCONJ
admet-276	159	7	conduct	conduct	NOUN
admet-276	159	8	of	of	ADP
admet-276	159	9	relevant	relevant	ADJ
admet-276	159	10	adme	adme	NOUN
admet-276	159	11	testing	testing	NOUN
admet-276	159	12	and	and	CCONJ
admet-276	159	13	fronting	fronting	ADJ
admet-276	159	14	loading	loading	NOUN
admet-276	159	15	pk	pk	NOUN
admet-276	159	16	/	/	SYM
admet-276	159	17	pd	pd	PROPN
admet-276	159	18	studies	study	NOUN
admet-276	159	19	as	as	ADV
admet-276	159	20	well	well	ADV
admet-276	159	21	as	as	ADP
admet-276	159	22	the	the	DET
admet-276	159	23	key	key	ADJ
admet-276	159	24	safety	safety	NOUN
admet-276	159	25	evaluations	evaluation	NOUN
admet-276	159	26	of	of	ADP
admet-276	159	27	lead	lead	ADJ
admet-276	159	28	molecules	molecule	NOUN
admet-276	159	29	as	as	ADV
admet-276	159	30	early	early	ADV
admet-276	159	31	as	as	ADP
admet-276	159	32	possible	possible	ADJ
admet-276	159	33	will	will	AUX
admet-276	159	34	facilitate	facilitate	VERB
admet-276	159	35	pcc	pcc	NOUN
admet-276	159	36	’s	’s	PART
admet-276	159	37	selection	selection	NOUN
admet-276	159	38	for	for	ADP
admet-276	159	39	their	their	PRON
admet-276	159	40	successful	successful	ADJ
admet-276	159	41	development	development	NOUN
admet-276	159	42	.	.	PUNCT
admet-276	160	1	3	3	X
admet-276	160	2	.	.	NOUN
admet-276	160	3	bioanalytical	bioanalytical	ADJ
admet-276	160	4	methods	method	NOUN
admet-276	160	5	and	and	CCONJ
admet-276	160	6	challenges	challenge	NOUN
admet-276	160	7	in	in	ADP
admet-276	160	8	the	the	DET
admet-276	160	9	past	past	ADJ
admet-276	160	10	several	several	ADJ
admet-276	160	11	decades	decade	NOUN
admet-276	160	12	of	of	ADP
admet-276	160	13	development	development	NOUN
admet-276	160	14	of	of	ADP
admet-276	160	15	sms	sms	PROPN
admet-276	160	16	,	,	PUNCT
admet-276	160	17	the	the	DET
admet-276	160	18	bioanalytical	bioanalytical	ADJ
admet-276	160	19	strategies	strategy	NOUN
admet-276	160	20	and	and	CCONJ
admet-276	160	21	approaches	approach	NOUN
admet-276	160	22	of	of	ADP
admet-276	160	23	sms	sm	NOUN
admet-276	160	24	have	have	AUX
admet-276	160	25	been	be	AUX
admet-276	160	26	well	well	ADV
admet-276	160	27	established	establish	VERB
admet-276	160	28	from	from	ADP
admet-276	160	29	method	method	NOUN
admet-276	160	30	development	development	NOUN
admet-276	160	31	,	,	PUNCT
admet-276	160	32	validation	validation	NOUN
admet-276	160	33	as	as	ADV
admet-276	160	34	well	well	ADV
admet-276	160	35	as	as	ADP
admet-276	160	36	method	method	NOUN
admet-276	160	37	transfer	transfer	NOUN
admet-276	160	38	from	from	ADP
admet-276	160	39	instrument	instrument	NOUN
admet-276	160	40	to	to	ADP
admet-276	160	41	instrument	instrument	NOUN
admet-276	160	42	and	and	CCONJ
admet-276	160	43	lab	lab	NOUN
admet-276	160	44	to	to	ADP
admet-276	160	45	lab	lab	NOUN
admet-276	160	46	based	base	VERB
admet-276	160	47	on	on	ADP
admet-276	160	48	lc	lc	PROPN
admet-276	160	49	-	-	PUNCT
admet-276	160	50	ms	ms	PROPN
admet-276	160	51	/	/	PROPN
admet-276	160	52	ms	ms	PROPN
admet-276	160	53	according	accord	VERB
admet-276	160	54	to	to	ADP
admet-276	160	55	fda	fda	PROPN
admet-276	160	56	bioanaltical	bioanaltical	ADJ
admet-276	160	57	method	method	PROPN
admet-276	160	58	guidance	guidance	NOUN
admet-276	160	59	[	[	X
admet-276	160	60	59	59	NUM
admet-276	160	61	]	]	PUNCT
admet-276	160	62	.	.	PUNCT
admet-276	161	1	differently	differently	ADV
admet-276	161	2	from	from	ADP
admet-276	161	3	sms	sms	PROPN
admet-276	161	4	,	,	PUNCT
admet-276	161	5	the	the	DET
admet-276	161	6	most	most	ADV
admet-276	161	7	commonly	commonly	ADV
admet-276	161	8	used	use	VERB
admet-276	161	9	bioanalytical	bioanalytical	ADJ
admet-276	161	10	methods	method	NOUN
admet-276	161	11	for	for	ADP
admet-276	161	12	lms	lm	NOUN
admet-276	161	13	are	be	AUX
admet-276	161	14	elisa	elisa	NOUN
admet-276	161	15	based	base	VERB
admet-276	161	16	assays	assay	NOUN
admet-276	161	17	by	by	ADP
admet-276	161	18	either	either	CCONJ
admet-276	161	19	direct	direct	ADJ
admet-276	161	20	or	or	CCONJ
admet-276	161	21	bridging	bridging	NOUN
admet-276	161	22	elisa	elisa	NOUN
admet-276	161	23	measuring	measure	VERB
admet-276	161	24	the	the	DET
admet-276	161	25	concentration	concentration	NOUN
admet-276	161	26	of	of	ADP
admet-276	161	27	the	the	DET
admet-276	161	28	therapeutic	therapeutic	ADJ
admet-276	161	29	over	over	ADP
admet-276	161	30	time	time	NOUN
admet-276	161	31	in	in	ADP
admet-276	161	32	plasma	plasma	NOUN
admet-276	161	33	or	or	CCONJ
admet-276	161	34	serum	serum	VERB
admet-276	161	35	for	for	ADP
admet-276	161	36	in	in	ADP
admet-276	161	37	vivo	vivo	ADJ
admet-276	161	38	studies	study	NOUN
admet-276	161	39	case	case	NOUN
admet-276	161	40	by	by	ADP
admet-276	161	41	case	case	NOUN
admet-276	161	42	.	.	PUNCT
admet-276	162	1	in	in	ADP
admet-276	162	2	comprehensive	comprehensive	ADJ
admet-276	162	3	reviews	review	NOUN
admet-276	162	4	and	and	CCONJ
admet-276	162	5	white	white	ADJ
admet-276	162	6	papers	paper	NOUN
admet-276	162	7	,	,	PUNCT
admet-276	162	8	several	several	ADJ
admet-276	162	9	bioanalytical	bioanalytical	ADJ
admet-276	162	10	methods	method	NOUN
admet-276	162	11	,	,	PUNCT
admet-276	162	12	considerations	consideration	NOUN
admet-276	162	13	and	and	CCONJ
admet-276	162	14	strategies	strategy	NOUN
admet-276	162	15	as	as	ADV
admet-276	162	16	well	well	ADV
admet-276	162	17	as	as	ADP
admet-276	162	18	challenges	challenge	NOUN
admet-276	162	19	have	have	AUX
admet-276	162	20	extensively	extensively	ADV
admet-276	162	21	been	be	AUX
admet-276	162	22	discussed	discuss	VERB
admet-276	162	23	for	for	ADP
admet-276	162	24	lms	lm	NOUN
admet-276	162	25	[	[	X
admet-276	162	26	42,46,60	42,46,60	NUM
admet-276	162	27	-	-	SYM
admet-276	162	28	66	66	NUM
admet-276	162	29	]	]	PUNCT
admet-276	162	30	.	.	PUNCT
admet-276	163	1	this	this	DET
admet-276	163	2	section	section	NOUN
admet-276	163	3	will	will	AUX
admet-276	163	4	provide	provide	VERB
admet-276	163	5	an	an	DET
admet-276	163	6	overview	overview	NOUN
admet-276	163	7	on	on	ADP
admet-276	163	8	recent	recent	ADJ
admet-276	163	9	advancements	advancement	NOUN
admet-276	163	10	in	in	ADP
admet-276	163	11	bioanalysis	bioanalysis	NOUN
admet-276	163	12	of	of	ADP
admet-276	163	13	mabs	mab	NOUN
admet-276	163	14	,	,	PUNCT
admet-276	163	15	adc	adc	PROPN
admet-276	163	16	,	,	PUNCT
admet-276	163	17	in	in	ADP
admet-276	163	18	particular	particular	ADJ
admet-276	163	19	with	with	ADP
admet-276	163	20	elisa	elisa	NOUN
admet-276	163	21	and	and	CCONJ
admet-276	163	22	lc	lc	PROPN
admet-276	163	23	-	-	PUNCT
admet-276	163	24	ms	ms	PROPN
admet-276	163	25	/	/	SYM
admet-276	163	26	ms	ms	PROPN
admet-276	163	27	technologies	technology	NOUN
admet-276	163	28	and	and	CCONJ
admet-276	163	29	related	relate	VERB
admet-276	163	30	new	new	ADJ
admet-276	163	31	approaches	approach	NOUN
admet-276	163	32	dealing	deal	VERB
admet-276	163	33	with	with	ADP
admet-276	163	34	matrix	matrix	NOUN
admet-276	163	35	interference	interference	NOUN
admet-276	163	36	.	.	PUNCT
admet-276	164	1	3.1	3.1	NUM
admet-276	164	2	high	high	ADJ
admet-276	164	3	-	-	PUNCT
admet-276	164	4	throughput	throughput	NOUN
admet-276	164	5	bioanalysis	bioanalysis	NOUN
admet-276	164	6	from	from	ADP
admet-276	164	7	industry	industry	NOUN
admet-276	164	8	drug	drug	NOUN
admet-276	164	9	screening	screening	NOUN
admet-276	164	10	perspective	perspective	NOUN
admet-276	164	11	,	,	PUNCT
admet-276	164	12	commercially	commercially	ADV
admet-276	164	13	automated	automate	VERB
admet-276	164	14	meso	meso	NOUN
admet-276	164	15	scale	scale	NOUN
admet-276	164	16	discovery	discovery	NOUN
admet-276	164	17	(	(	PUNCT
admet-276	164	18	msd	msd	NOUN
admet-276	164	19	)	)	PUNCT
admet-276	164	20	format	format	NOUN
admet-276	164	21	and	and	CCONJ
admet-276	164	22	nonoscale	nonoscale	ADJ
admet-276	164	23	immunoassay	immunoassay	ADJ
admet-276	164	24	platform	platform	NOUN
admet-276	164	25	on	on	ADP
admet-276	164	26	gyrolab	gyrolab	PROPN
admet-276	164	27	offer	offer	VERB
admet-276	164	28	high	high	ADJ
admet-276	164	29	-	-	PUNCT
admet-276	164	30	throughput	throughput	NOUN
admet-276	164	31	capabilities	capability	NOUN
admet-276	164	32	of	of	ADP
admet-276	164	33	elisa	elisa	NOUN
admet-276	164	34	bioanalysis	bioanalysis	NOUN
admet-276	164	35	,	,	PUNCT
admet-276	164	36	which	which	PRON
admet-276	164	37	enhances	enhance	VERB
admet-276	164	38	overall	overall	ADJ
admet-276	164	39	performance	performance	NOUN
admet-276	164	40	of	of	ADP
admet-276	164	41	traditional	traditional	ADJ
admet-276	164	42	manual	manual	ADJ
admet-276	164	43	elisa	elisa	NOUN
admet-276	164	44	assay	assay	VERB
admet-276	164	45	with	with	ADP
admet-276	164	46	several	several	ADJ
admet-276	164	47	advantages	advantage	NOUN
admet-276	164	48	in	in	ADP
admet-276	164	49	terms	term	NOUN
admet-276	164	50	of	of	ADP
admet-276	164	51	sample	sample	NOUN
admet-276	164	52	amount	amount	NOUN
admet-276	164	53	,	,	PUNCT
admet-276	164	54	broader	broad	ADJ
admet-276	164	55	dynamic	dynamic	ADJ
admet-276	164	56	linearity	linearity	NOUN
admet-276	164	57	,	,	PUNCT
admet-276	164	58	throughput	throughput	NOUN
admet-276	164	59	,	,	PUNCT
admet-276	164	60	higher	high	ADJ
admet-276	164	61	sensitivity	sensitivity	NOUN
admet-276	164	62	and	and	CCONJ
admet-276	164	63	reproducibility	reproducibility	NOUN
admet-276	164	64	[	[	X
admet-276	164	65	67,68	67,68	NUM
admet-276	164	66	]	]	PUNCT
admet-276	164	67	.	.	PUNCT
admet-276	165	1	moreover	moreover	ADV
admet-276	165	2	,	,	PUNCT
admet-276	165	3	both	both	CCONJ
admet-276	165	4	the	the	DET
admet-276	165	5	antibody	antibody	NOUN
admet-276	165	6	and	and	CCONJ
admet-276	165	7	ada	ada	PROPN
admet-276	165	8	of	of	ADP
admet-276	165	9	an	an	DET
admet-276	165	10	antibody	antibody	NOUN
admet-276	165	11	or	or	CCONJ
admet-276	165	12	adc	adc	PROPN
admet-276	165	13	and	and	CCONJ
admet-276	165	14	ata	ata	VERB
admet-276	165	15	from	from	ADP
admet-276	165	16	pk	pk	NOUN
admet-276	165	17	plasma	plasma	NOUN
admet-276	165	18	samples	sample	NOUN
admet-276	165	19	can	can	AUX
admet-276	165	20	be	be	AUX
admet-276	165	21	hong	hong	PROPN
admet-276	165	22	wan	wan	PROPN
admet-276	165	23	admet	admet	PROPN
admet-276	165	24	&	&	CCONJ
admet-276	165	25	dmpk	dmpk	PROPN
admet-276	165	26	4(1	4(1	NOUN
admet-276	165	27	)	)	PUNCT
admet-276	165	28	(	(	PUNCT
admet-276	165	29	2016	2016	NUM
admet-276	165	30	)	)	PUNCT
admet-276	165	31	1	1	NUM
admet-276	165	32	-	-	SYM
admet-276	165	33	22	22	NUM
admet-276	165	34	10	10	NUM
admet-276	165	35	quantified	quantify	VERB
admet-276	165	36	simultaneously	simultaneously	ADV
admet-276	165	37	.	.	PUNCT
admet-276	166	1	in	in	ADP
admet-276	166	2	particular	particular	ADJ
admet-276	166	3	,	,	PUNCT
admet-276	166	4	the	the	DET
admet-276	166	5	nanoscale	nanoscale	NOUN
admet-276	166	6	volume	volume	NOUN
admet-276	166	7	of	of	ADP
admet-276	166	8	microfludic	microfludic	ADJ
admet-276	166	9	platform	platform	NOUN
admet-276	166	10	on	on	ADP
admet-276	166	11	gyros	gyros	X
admet-276	166	12	has	have	AUX
admet-276	166	13	made	make	VERB
admet-276	166	14	it	it	PRON
admet-276	166	15	durable	durable	ADJ
admet-276	166	16	to	to	PART
admet-276	166	17	gain	gain	VERB
admet-276	166	18	the	the	DET
admet-276	166	19	pk	pk	NOUN
admet-276	166	20	data	datum	NOUN
admet-276	166	21	of	of	ADP
admet-276	166	22	antibody	antibody	NOUN
admet-276	166	23	from	from	ADP
admet-276	166	24	one	one	NUM
admet-276	166	25	single	single	ADJ
admet-276	166	26	mouse	mouse	NOUN
admet-276	166	27	study	study	NOUN
admet-276	166	28	by	by	ADP
admet-276	166	29	whole	whole	ADJ
admet-276	166	30	blood	blood	NOUN
admet-276	166	31	serial	serial	NOUN
admet-276	166	32	sampling	sample	VERB
admet-276	166	33	with	with	ADP
admet-276	166	34	significantly	significantly	ADV
admet-276	166	35	reducing	reduce	VERB
admet-276	166	36	study	study	NOUN
admet-276	166	37	cost	cost	NOUN
admet-276	166	38	and	and	CCONJ
admet-276	166	39	animal	animal	NOUN
admet-276	166	40	usage	usage	NOUN
admet-276	166	41	,	,	PUNCT
admet-276	166	42	offering	offer	VERB
admet-276	166	43	comparable	comparable	ADJ
admet-276	166	44	pk	pk	NOUN
admet-276	166	45	data	datum	NOUN
admet-276	166	46	as	as	ADP
admet-276	166	47	conventional	conventional	ADJ
admet-276	166	48	composite	composite	ADJ
admet-276	166	49	sampling	sampling	NOUN
admet-276	166	50	[	[	X
admet-276	166	51	69	69	NUM
admet-276	166	52	]	]	PUNCT
admet-276	166	53	.	.	PUNCT
admet-276	167	1	furthermore	furthermore	ADV
admet-276	167	2	,	,	PUNCT
admet-276	167	3	this	this	DET
admet-276	167	4	microfludic	microfludic	ADJ
admet-276	167	5	approach	approach	NOUN
admet-276	167	6	has	have	AUX
admet-276	167	7	been	be	AUX
admet-276	167	8	applied	apply	VERB
admet-276	167	9	to	to	ADP
admet-276	167	10	high	high	ADJ
admet-276	167	11	-	-	PUNCT
admet-276	167	12	throughput	throughput	NOUN
admet-276	167	13	quantification	quantification	NOUN
admet-276	167	14	of	of	ADP
admet-276	167	15	host	host	NOUN
admet-276	167	16	cell	cell	NOUN
admet-276	167	17	protein	protein	NOUN
admet-276	167	18	impurities	impurity	NOUN
admet-276	167	19	for	for	ADP
admet-276	167	20	bioprocess	bioprocess	NOUN
admet-276	167	21	development	development	NOUN
admet-276	167	22	[	[	X
admet-276	167	23	70	70	NUM
admet-276	167	24	]	]	PUNCT
admet-276	167	25	.	.	PUNCT
admet-276	168	1	it	it	PRON
admet-276	168	2	demonstrated	demonstrate	VERB
admet-276	168	3	an	an	DET
admet-276	168	4	improved	improved	ADJ
admet-276	168	5	throughput	throughput	NOUN
admet-276	168	6	(	(	PUNCT
admet-276	168	7	5	5	NUM
admet-276	168	8	-	-	SYM
admet-276	168	9	10	10	NUM
admet-276	168	10	times	time	NOUN
admet-276	168	11	faster	fast	ADV
admet-276	168	12	)	)	PUNCT
admet-276	168	13	,	,	PUNCT
admet-276	168	14	broader	broad	ADJ
admet-276	168	15	dynamic	dynamic	ADJ
admet-276	168	16	range	range	NOUN
admet-276	168	17	(	(	PUNCT
admet-276	168	18	100	100	NUM
admet-276	168	19	-	-	PUNCT
admet-276	168	20	times	time	NOUN
admet-276	168	21	)	)	PUNCT
admet-276	168	22	and	and	CCONJ
admet-276	168	23	decreased	decrease	VERB
admet-276	168	24	sample	sample	NOUN
admet-276	168	25	consumption	consumption	NOUN
admet-276	168	26	,	,	PUNCT
admet-276	168	27	hands	hand	NOUN
admet-276	168	28	on	on	ADP
admet-276	168	29	time	time	NOUN
admet-276	168	30	and	and	CCONJ
admet-276	168	31	duration	duration	NOUN
admet-276	168	32	for	for	ADP
admet-276	168	33	assay	assay	NOUN
admet-276	168	34	development	development	NOUN
admet-276	168	35	compared	compare	VERB
admet-276	168	36	with	with	ADP
admet-276	168	37	tecan	tecan	ADJ
admet-276	168	38	plate	plate	NOUN
admet-276	168	39	-	-	PUNCT
admet-276	168	40	based	base	VERB
admet-276	168	41	elisa	elisa	NOUN
admet-276	168	42	[	[	X
admet-276	168	43	70	70	NUM
admet-276	168	44	]	]	PUNCT
admet-276	168	45	.	.	PUNCT
admet-276	169	1	with	with	ADP
admet-276	169	2	those	those	DET
admet-276	169	3	automated	automate	VERB
admet-276	169	4	instruments	instrument	NOUN
admet-276	169	5	,	,	PUNCT
admet-276	169	6	elisa	elisa	PROPN
admet-276	169	7	based	base	VERB
admet-276	169	8	bioanalytical	bioanalytical	ADJ
admet-276	169	9	methods	method	NOUN
admet-276	169	10	become	become	VERB
admet-276	169	11	easier	easy	ADJ
admet-276	169	12	transferring	transfer	VERB
admet-276	169	13	from	from	ADP
admet-276	169	14	preclinical	preclinical	ADJ
admet-276	169	15	to	to	ADP
admet-276	169	16	clinical	clinical	ADJ
admet-276	169	17	between	between	ADP
admet-276	169	18	labs	lab	NOUN
admet-276	169	19	and	and	CCONJ
admet-276	169	20	cros	cro	NOUN
admet-276	169	21	,	,	PUNCT
admet-276	169	22	which	which	PRON
admet-276	169	23	can	can	AUX
admet-276	169	24	considerably	considerably	ADV
admet-276	169	25	speed	speed	VERB
admet-276	169	26	up	up	ADP
admet-276	169	27	large	large	ADJ
admet-276	169	28	molecule	molecule	NOUN
admet-276	169	29	drug	drug	NOUN
admet-276	169	30	discovery	discovery	NOUN
admet-276	169	31	process	process	NOUN
admet-276	169	32	and	and	CCONJ
admet-276	169	33	clinical	clinical	ADJ
admet-276	169	34	development	development	NOUN
admet-276	169	35	.	.	PUNCT
admet-276	170	1	furthermore	furthermore	ADV
admet-276	170	2	,	,	PUNCT
admet-276	170	3	traditional	traditional	ADJ
admet-276	170	4	elisa	elisa	NOUN
admet-276	170	5	approach	approach	NOUN
admet-276	170	6	was	be	AUX
admet-276	170	7	transferred	transfer	VERB
admet-276	170	8	to	to	ADP
admet-276	170	9	an	an	DET
admet-276	170	10	automated	automate	VERB
admet-276	170	11	microfluidics	microfluidic	NOUN
admet-276	170	12	immunoassay	immunoassay	PROPN
admet-276	170	13	platform	platform	NOUN
admet-276	170	14	based	base	VERB
admet-276	170	15	on	on	ADP
admet-276	170	16	nanoscale	nanoscale	NOUN
admet-276	170	17	streptavidin	streptavidin	NOUN
admet-276	170	18	bead	bead	NOUN
admet-276	170	19	columns	column	NOUN
admet-276	170	20	enable	enable	VERB
admet-276	170	21	highthroughput	highthroughput	NOUN
admet-276	170	22	bioanalysis	bioanalysis	NOUN
admet-276	170	23	of	of	ADP
admet-276	170	24	a	a	DET
admet-276	170	25	human	human	ADJ
admet-276	170	26	mab	mab	NOUN
admet-276	170	27	in	in	ADP
admet-276	170	28	preclinical	preclinical	ADJ
admet-276	170	29	pk	pk	NOUN
admet-276	170	30	samples	sample	NOUN
admet-276	170	31	with	with	ADP
admet-276	170	32	enhanced	enhanced	ADJ
admet-276	170	33	bioanalysis	bioanalysis	NOUN
admet-276	170	34	capacity	capacity	NOUN
admet-276	170	35	[	[	X
admet-276	170	36	71	71	NUM
admet-276	170	37	]	]	PUNCT
admet-276	170	38	.	.	PUNCT
admet-276	171	1	additionally	additionally	ADV
admet-276	171	2	,	,	PUNCT
admet-276	171	3	a	a	DET
admet-276	171	4	high	high	ADJ
admet-276	171	5	-	-	PUNCT
admet-276	171	6	throughput	throughput	NOUN
admet-276	171	7	capillary	capillary	ADJ
admet-276	171	8	electrophoresis	electrophoresis	NOUN
admet-276	171	9	based	base	VERB
admet-276	171	10	microfluidic	microfluidic	ADJ
admet-276	171	11	device	device	NOUN
admet-276	171	12	(	(	PUNCT
admet-276	171	13	labchip	labchip	NOUN
admet-276	171	14	gxii	gxii	NOUN
admet-276	171	15	)	)	PUNCT
admet-276	171	16	was	be	AUX
admet-276	171	17	applied	apply	VERB
admet-276	171	18	to	to	PART
admet-276	171	19	obtain	obtain	VERB
admet-276	171	20	pharmacokinetics	pharmacokinetic	NOUN
admet-276	171	21	(	(	PUNCT
admet-276	171	22	pk	pk	NOUN
admet-276	171	23	)	)	PUNCT
admet-276	171	24	of	of	ADP
admet-276	171	25	a	a	DET
admet-276	171	26	fluorescently	fluorescently	ADV
admet-276	171	27	labeled	label	VERB
admet-276	171	28	human	human	ADJ
admet-276	171	29	mab	mab	NOUN
admet-276	171	30	directly	directly	ADV
admet-276	171	31	in	in	ADP
admet-276	171	32	single	single	ADJ
admet-276	171	33	dose	dose	NOUN
admet-276	171	34	rat	rat	NOUN
admet-276	171	35	pk	pk	PROPN
admet-276	171	36	studies	study	NOUN
admet-276	171	37	[	[	X
admet-276	171	38	72	72	NUM
admet-276	171	39	]	]	SYM
admet-276	171	40	.	.	PUNCT
admet-276	172	1	3.2	3.2	NUM
admet-276	172	2	lc	lc	PROPN
admet-276	172	3	-	-	PUNCT
admet-276	172	4	ms	ms	PROPN
admet-276	172	5	/	/	SYM
admet-276	172	6	ms	ms	PROPN
admet-276	172	7	and	and	CCONJ
admet-276	172	8	bla	bla	NOUN
admet-276	172	9	bioanalysis	bioanalysis	NOUN
admet-276	172	10	of	of	ADP
admet-276	172	11	mabs	mab	NOUN
admet-276	172	12	as	as	SCONJ
admet-276	172	13	mentioned	mention	VERB
admet-276	172	14	above	above	ADV
admet-276	172	15	,	,	PUNCT
admet-276	172	16	lba	lba	PROPN
admet-276	172	17	-	-	PUNCT
admet-276	172	18	based	base	VERB
admet-276	172	19	elisa	elisa	NOUN
admet-276	172	20	is	be	AUX
admet-276	172	21	the	the	DET
admet-276	172	22	commonly	commonly	ADV
admet-276	172	23	used	use	VERB
admet-276	172	24	gold	gold	NOUN
admet-276	172	25	standard	standard	ADJ
admet-276	172	26	method	method	NOUN
admet-276	172	27	for	for	ADP
admet-276	172	28	bioanalysis	bioanalysis	NOUN
admet-276	172	29	of	of	ADP
admet-276	172	30	mabs	mab	NOUN
admet-276	172	31	.	.	PUNCT
admet-276	173	1	recent	recent	ADJ
admet-276	173	2	advances	advance	NOUN
admet-276	173	3	in	in	ADP
admet-276	173	4	instrumentation	instrumentation	NOUN
admet-276	173	5	technology	technology	NOUN
admet-276	173	6	have	have	AUX
admet-276	173	7	significantly	significantly	ADV
admet-276	173	8	increased	increase	VERB
admet-276	173	9	the	the	DET
admet-276	173	10	sensitivity	sensitivity	NOUN
admet-276	173	11	and	and	CCONJ
admet-276	173	12	versatility	versatility	NOUN
admet-276	173	13	of	of	ADP
admet-276	173	14	lc	lc	PROPN
admet-276	173	15	-	-	PUNCT
admet-276	173	16	ms	ms	PROPN
admet-276	173	17	/	/	SYM
admet-276	173	18	ms	ms	PROPN
admet-276	173	19	,	,	PUNCT
admet-276	173	20	making	make	VERB
admet-276	173	21	it	it	PRON
admet-276	173	22	an	an	DET
admet-276	173	23	alternative	alternative	ADJ
admet-276	173	24	tool	tool	NOUN
admet-276	173	25	for	for	ADP
admet-276	173	26	large	large	ADJ
admet-276	173	27	molecule	molecule	NOUN
admet-276	173	28	drug	drug	NOUN
admet-276	173	29	development	development	NOUN
admet-276	173	30	.	.	PUNCT
admet-276	174	1	with	with	ADP
admet-276	174	2	appropriate	appropriate	ADJ
admet-276	174	3	sample	sample	NOUN
admet-276	174	4	preparation	preparation	NOUN
admet-276	174	5	(	(	PUNCT
admet-276	174	6	based	base	VERB
admet-276	174	7	on	on	ADP
admet-276	174	8	the	the	DET
admet-276	174	9	mw	mw	NOUN
admet-276	174	10	and	and	CCONJ
admet-276	174	11	concentration	concentration	NOUN
admet-276	174	12	of	of	ADP
admet-276	174	13	the	the	DET
admet-276	174	14	target	target	NOUN
admet-276	174	15	analyte	analyte	NOUN
admet-276	174	16	of	of	ADP
admet-276	174	17	interest	interest	NOUN
admet-276	174	18	)	)	PUNCT
admet-276	174	19	,	,	PUNCT
admet-276	174	20	immmunocapture	immmunocapture	ADJ
admet-276	174	21	lc	lc	PROPN
admet-276	174	22	-	-	PUNCT
admet-276	174	23	ms	ms	PROPN
admet-276	174	24	/	/	SYM
admet-276	174	25	ms	ms	NOUN
admet-276	174	26	methods	method	NOUN
admet-276	174	27	can	can	AUX
admet-276	174	28	achieve	achieve	VERB
admet-276	174	29	levels	level	NOUN
admet-276	174	30	of	of	ADP
admet-276	174	31	high	high	ADJ
admet-276	174	32	sensitivity	sensitivity	NOUN
admet-276	174	33	down	down	ADV
admet-276	174	34	to	to	ADP
admet-276	174	35	0.01	0.01	NUM
admet-276	174	36	to	to	PART
admet-276	174	37	0.1	0.1	NUM
admet-276	174	38	nm	nm	ADV
admet-276	174	39	closer	close	ADV
admet-276	174	40	to	to	PART
admet-276	174	41	elisa	elisa	VERB
admet-276	174	42	assays	assay	NOUN
admet-276	174	43	with	with	ADP
admet-276	174	44	a	a	DET
admet-276	174	45	large	large	ADJ
admet-276	174	46	dynamic	dynamic	ADJ
admet-276	174	47	range	range	NOUN
admet-276	174	48	and	and	CCONJ
admet-276	174	49	orthogonal	orthogonal	ADJ
admet-276	174	50	specificity	specificity	NOUN
admet-276	174	51	that	that	PRON
admet-276	174	52	is	be	AUX
admet-276	174	53	generally	generally	ADV
admet-276	174	54	unaffected	unaffected	ADJ
admet-276	174	55	by	by	ADP
admet-276	174	56	crossreaction	crossreaction	NOUN
admet-276	174	57	issues	issue	NOUN
admet-276	174	58	[	[	X
admet-276	174	59	61	61	NUM
admet-276	174	60	]	]	PUNCT
admet-276	174	61	.	.	PUNCT
admet-276	175	1	in	in	ADP
admet-276	175	2	recent	recent	ADJ
admet-276	175	3	comparative	comparative	ADJ
admet-276	175	4	studies	study	NOUN
admet-276	175	5	,	,	PUNCT
admet-276	175	6	peng	peng	PROPN
admet-276	175	7	et	et	PROPN
admet-276	175	8	al	al	PROPN
admet-276	175	9	.	.	PROPN
admet-276	175	10	developed	develop	VERB
admet-276	175	11	and	and	CCONJ
admet-276	175	12	validated	validate	VERB
admet-276	175	13	a	a	DET
admet-276	175	14	simple	simple	ADJ
admet-276	175	15	,	,	PUNCT
admet-276	175	16	sensitive	sensitive	ADJ
admet-276	175	17	,	,	PUNCT
admet-276	175	18	specific	specific	ADJ
admet-276	175	19	and	and	CCONJ
admet-276	175	20	precise	precise	ADJ
admet-276	175	21	lc	lc	PROPN
admet-276	175	22	–	–	PUNCT
admet-276	175	23	ms	ms	PROPN
admet-276	175	24	/	/	SYM
admet-276	175	25	ms	ms	PROPN
admet-276	175	26	assay	assay	PROPN
admet-276	175	27	for	for	ADP
admet-276	175	28	quantitation	quantitation	NOUN
admet-276	175	29	of	of	ADP
admet-276	175	30	infliximab	infliximab	PROPN
admet-276	175	31	pk	pk	PROPN
admet-276	175	32	in	in	ADP
admet-276	175	33	human	human	ADJ
admet-276	175	34	serum	serum	NOUN
admet-276	175	35	by	by	ADP
admet-276	175	36	using	use	VERB
admet-276	175	37	isotopelabeled	isotopelabele	VERB
admet-276	175	38	signature	signature	NOUN
admet-276	175	39	peptide	peptide	NOUN
admet-276	175	40	as	as	SCONJ
admet-276	175	41	the	the	DET
admet-276	175	42	internal	internal	ADJ
admet-276	175	43	standard	standard	NOUN
admet-276	175	44	(	(	PUNCT
admet-276	175	45	is	be	AUX
admet-276	175	46	)	)	PUNCT
admet-276	175	47	,	,	PUNCT
admet-276	175	48	which	which	PRON
admet-276	175	49	achieved	achieve	VERB
admet-276	175	50	an	an	DET
admet-276	175	51	excellent	excellent	ADJ
admet-276	175	52	correlation	correlation	NOUN
admet-276	175	53	with	with	ADP
admet-276	175	54	elisa	elisa	NOUN
admet-276	175	55	detection	detection	NOUN
admet-276	175	56	[	[	X
admet-276	175	57	73	73	NUM
admet-276	175	58	]	]	PUNCT
admet-276	175	59	.	.	PUNCT
admet-276	176	1	park	park	NOUN
admet-276	176	2	et	et	PROPN
admet-276	176	3	al	al	PROPN
admet-276	176	4	.	.	PROPN
admet-276	176	5	applied	apply	VERB
admet-276	176	6	lc	lc	PROPN
admet-276	176	7	-	-	PUNCT
admet-276	176	8	ms	ms	PROPN
admet-276	176	9	/	/	SYM
admet-276	176	10	ms	ms	PROPN
admet-276	176	11	quadruple	quadruple	PROPN
admet-276	176	12	time	time	NOUN
admet-276	176	13	-	-	PUNCT
admet-276	176	14	of	of	ADP
admet-276	176	15	-	-	PUNCT
admet-276	176	16	flight	flight	NOUN
admet-276	176	17	mass	mass	NOUN
admet-276	176	18	spectrometric	spectrometric	ADJ
admet-276	176	19	method	method	NOUN
admet-276	176	20	(	(	PUNCT
admet-276	176	21	qtof	qtof	PROPN
admet-276	176	22	)	)	PUNCT
admet-276	176	23	for	for	ADP
admet-276	176	24	the	the	DET
admet-276	176	25	determination	determination	NOUN
admet-276	176	26	of	of	ADP
admet-276	176	27	trastuzumab	trastuzumab	NOUN
admet-276	176	28	in	in	ADP
admet-276	176	29	rat	rat	NOUN
admet-276	176	30	plasma	plasma	NOUN
admet-276	176	31	with	with	ADP
admet-276	176	32	good	good	ADJ
admet-276	176	33	sensitivity	sensitivity	NOUN
admet-276	176	34	(	(	PUNCT
admet-276	176	35	llod	llod	NOUN
admet-276	176	36	0.5	0.5	NUM
admet-276	176	37	µg	µg	NOUN
admet-276	176	38	/	/	SYM
admet-276	176	39	ml	ml	NOUN
admet-276	176	40	)	)	PUNCT
admet-276	176	41	and	and	CCONJ
admet-276	176	42	results	result	NOUN
admet-276	176	43	in	in	ADP
admet-276	176	44	consistence	consistence	NOUN
admet-276	176	45	with	with	ADP
admet-276	176	46	elisa	elisa	PROPN
admet-276	176	47	assay	assay	PROPN
admet-276	176	48	(	(	PUNCT
admet-276	176	49	r2=0.9104	r2=0.9104	NOUN
admet-276	176	50	)	)	PUNCT
admet-276	177	1	[	[	X
admet-276	177	2	74	74	NUM
admet-276	177	3	]	]	PUNCT
admet-276	177	4	.	.	PUNCT
admet-276	178	1	zhang	zhang	PROPN
admet-276	178	2	et	et	PROPN
admet-276	178	3	al	al	PROPN
admet-276	178	4	.	.	PROPN
admet-276	178	5	reported	report	VERB
admet-276	178	6	a	a	DET
admet-276	178	7	generic	generic	ADJ
admet-276	178	8	automated	automate	VERB
admet-276	178	9	lc	lc	PROPN
admet-276	178	10	-	-	PUNCT
admet-276	178	11	ms	ms	PROPN
admet-276	178	12	/	/	SYM
admet-276	178	13	ms	ms	PROPN
admet-276	178	14	method	method	NOUN
admet-276	178	15	for	for	ADP
admet-276	178	16	the	the	DET
admet-276	178	17	pharmacokinetic	pharmacokinetic	ADJ
admet-276	178	18	study	study	NOUN
admet-276	178	19	of	of	ADP
admet-276	178	20	a	a	DET
admet-276	178	21	mab	mab	NOUN
admet-276	178	22	in	in	ADP
admet-276	178	23	cynomolgus	cynomolgus	ADJ
admet-276	178	24	monkey	monkey	NOUN
admet-276	178	25	with	with	ADP
admet-276	178	26	comparable	comparable	ADJ
admet-276	178	27	data	datum	NOUN
admet-276	178	28	by	by	ADP
admet-276	178	29	the	the	DET
admet-276	178	30	immunoassay	immunoassay	PROPN
admet-276	178	31	data	datum	NOUN
admet-276	178	32	as	as	ADV
admet-276	178	33	well	well	ADV
admet-276	178	34	[	[	X
admet-276	178	35	75	75	NUM
admet-276	178	36	]	]	PUNCT
admet-276	178	37	.	.	PUNCT
admet-276	179	1	li	li	PROPN
admet-276	179	2	et	et	PROPN
admet-276	179	3	al	al	PROPN
admet-276	179	4	.	.	PROPN
admet-276	179	5	developed	develop	VERB
admet-276	179	6	a	a	DET
admet-276	179	7	general	general	ADJ
admet-276	179	8	lc	lc	PROPN
admet-276	179	9	-	-	PUNCT
admet-276	179	10	ms	ms	PROPN
admet-276	179	11	/	/	SYM
admet-276	179	12	ms	ms	PROPN
admet-276	179	13	method	method	NOUN
admet-276	179	14	approach	approach	NOUN
admet-276	179	15	employing	employ	VERB
admet-276	179	16	an	an	DET
admet-276	179	17	uniformly	uniformly	ADV
admet-276	179	18	heavy	heavy	ADJ
admet-276	179	19	-	-	PUNCT
admet-276	179	20	isotope	isotope	NOUN
admet-276	179	21	labeled	label	VERB
admet-276	179	22	common	common	ADJ
admet-276	179	23	whole	whole	ADJ
admet-276	179	24	mab	mab	NOUN
admet-276	179	25	is	be	AUX
admet-276	179	26	and	and	CCONJ
admet-276	179	27	a	a	DET
admet-276	179	28	common	common	ADJ
admet-276	179	29	immunocapture	immunocapture	NOUN
admet-276	179	30	for	for	ADP
admet-276	179	31	sample	sample	NOUN
admet-276	179	32	processing	processing	NOUN
admet-276	179	33	for	for	ADP
admet-276	179	34	qualification	qualification	NOUN
admet-276	179	35	of	of	ADP
admet-276	179	36	four	four	NUM
admet-276	179	37	igg(2	igg(2	NOUN
admet-276	179	38	)	)	PUNCT
admet-276	179	39	and	and	CCONJ
admet-276	179	40	four	four	NUM
admet-276	179	41	igg(1	igg(1	NOUN
admet-276	179	42	)	)	PUNCT
admet-276	179	43	mabs	mab	NOUN
admet-276	179	44	.	.	PUNCT
admet-276	180	1	this	this	DET
admet-276	180	2	general	general	ADJ
admet-276	180	3	lc	lc	PROPN
admet-276	180	4	-	-	PUNCT
admet-276	180	5	ms	ms	PROPN
admet-276	180	6	/	/	SYM
admet-276	180	7	ms	ms	PROPN
admet-276	180	8	method	method	PROPN
admet-276	180	9	approach	approach	NOUN
admet-276	180	10	overcomes	overcome	VERB
admet-276	180	11	the	the	DET
admet-276	180	12	limitations	limitation	NOUN
admet-276	180	13	of	of	ADP
admet-276	180	14	current	current	ADJ
admet-276	180	15	methods	method	NOUN
admet-276	180	16	to	to	PART
admet-276	180	17	reduce	reduce	VERB
admet-276	180	18	time	time	NOUN
admet-276	180	19	and	and	CCONJ
admet-276	180	20	resources	resource	NOUN
admet-276	180	21	required	require	VERB
admet-276	180	22	for	for	ADP
admet-276	180	23	preclinical	preclinical	ADJ
admet-276	180	24	studies	study	NOUN
admet-276	180	25	[	[	X
admet-276	180	26	76	76	NUM
admet-276	180	27	]	]	PUNCT
admet-276	180	28	.	.	PUNCT
admet-276	181	1	the	the	DET
admet-276	181	2	key	key	ADJ
admet-276	181	3	benefits	benefit	NOUN
admet-276	181	4	of	of	ADP
admet-276	181	5	lc	lc	NOUN
admet-276	181	6	-	-	PUNCT
admet-276	181	7	ms	ms	PROPN
admet-276	181	8	/	/	SYM
admet-276	181	9	ms	ms	PROPN
admet-276	181	10	over	over	ADP
admet-276	181	11	elisa	elisa	PROPN
admet-276	181	12	based	base	VERB
admet-276	181	13	method	method	NOUN
admet-276	181	14	are	be	AUX
admet-276	181	15	its	its	PRON
admet-276	181	16	high	high	ADJ
admet-276	181	17	degree	degree	NOUN
admet-276	181	18	of	of	ADP
admet-276	181	19	specificity	specificity	NOUN
admet-276	181	20	and	and	CCONJ
admet-276	181	21	its	its	PRON
admet-276	181	22	ability	ability	NOUN
admet-276	181	23	to	to	PART
admet-276	181	24	simultaneously	simultaneously	ADV
admet-276	181	25	resolve	resolve	VERB
admet-276	181	26	,	,	PUNCT
admet-276	181	27	detect	detect	VERB
admet-276	181	28	,	,	PUNCT
admet-276	181	29	and	and	CCONJ
admet-276	181	30	quantify	quantify	VERB
admet-276	181	31	multiple	multiple	ADJ
admet-276	181	32	peptides	peptide	NOUN
admet-276	181	33	in	in	ADP
admet-276	181	34	biological	biological	ADJ
admet-276	181	35	samples	sample	NOUN
admet-276	181	36	or	or	CCONJ
admet-276	181	37	their	their	PRON
admet-276	181	38	extracts	extract	NOUN
admet-276	181	39	,	,	PUNCT
admet-276	181	40	as	as	ADV
admet-276	181	41	well	well	ADV
admet-276	181	42	as	as	ADP
admet-276	181	43	even	even	ADV
admet-276	181	44	able	able	ADJ
admet-276	181	45	to	to	PART
admet-276	181	46	identify	identify	VERB
admet-276	181	47	key	key	ADJ
admet-276	181	48	metabolites	metabolite	NOUN
admet-276	181	49	of	of	ADP
admet-276	181	50	biologics	biologic	NOUN
admet-276	181	51	,	,	PUNCT
admet-276	181	52	in	in	ADP
admet-276	181	53	-	-	PUNCT
admet-276	181	54	depth	depth	NOUN
admet-276	181	55	structural	structural	ADJ
admet-276	181	56	characterization	characterization	NOUN
admet-276	181	57	and	and	CCONJ
admet-276	181	58	functional	functional	ADJ
admet-276	181	59	insights	insight	NOUN
admet-276	181	60	of	of	ADP
admet-276	181	61	therapeutic	therapeutic	ADJ
admet-276	181	62	mabs	mab	NOUN
admet-276	181	63	,	,	PUNCT
admet-276	181	64	e.g.	e.g.	ADV
admet-276	181	65	,	,	PUNCT
admet-276	181	66	differentiating	differentiate	VERB
admet-276	181	67	biosimilar	biosimilar	NOUN
admet-276	181	68	to	to	ADP
admet-276	181	69	originator	originator	NOUN
admet-276	181	70	mabs	mab	NOUN
admet-276	181	71	as	as	ADP
admet-276	181	72	the	the	DET
admet-276	181	73	case	case	NOUN
admet-276	181	74	of	of	ADP
admet-276	181	75	trastuzumab	trastuzumab	NOUN
admet-276	181	76	and	and	CCONJ
admet-276	181	77	cetuximab	cetuximab	NOUN
admet-276	181	78	,	,	PUNCT
admet-276	181	79	which	which	PRON
admet-276	181	80	will	will	AUX
admet-276	181	81	be	be	AUX
admet-276	181	82	valuable	valuable	ADJ
admet-276	181	83	for	for	ADP
admet-276	181	84	biobetters	biobetter	NOUN
admet-276	181	85	and	and	CCONJ
admet-276	181	86	next	next	ADJ
admet-276	181	87	generation	generation	NOUN
admet-276	181	88	antibodies	antibodie	VERB
admet-276	181	89	design	design	NOUN
admet-276	181	90	and	and	CCONJ
admet-276	181	91	optimization	optimization	NOUN
admet-276	181	92	[	[	X
admet-276	181	93	77	77	NUM
admet-276	181	94	]	]	PUNCT
admet-276	181	95	.	.	PUNCT
admet-276	182	1	highly	highly	ADV
admet-276	182	2	selective	selective	ADJ
admet-276	182	3	lc	lc	NOUN
admet-276	182	4	-	-	PUNCT
admet-276	182	5	ms	ms	PROPN
admet-276	182	6	/	/	PROPN
admet-276	182	7	ms	ms	NOUN
admet-276	182	8	made	make	VERB
admet-276	182	9	it	it	PRON
admet-276	182	10	possible	possible	ADJ
admet-276	182	11	for	for	ADP
admet-276	182	12	simultaneous	simultaneous	ADJ
admet-276	182	13	quantification	quantification	NOUN
admet-276	182	14	of	of	ADP
admet-276	182	15	several	several	ADJ
admet-276	182	16	co	co	ADJ
admet-276	182	17	-	-	ADJ
admet-276	182	18	administered	administer	VERB
admet-276	182	19	human	human	ADJ
admet-276	182	20	antibodies	antibody	NOUN
admet-276	182	21	(	(	PUNCT
admet-276	182	22	mabs	mab	NOUN
admet-276	182	23	)	)	PUNCT
admet-276	182	24	,	,	PUNCT
admet-276	182	25	mab	mab	NOUN
admet-276	182	26	-	-	PUNCT
admet-276	182	27	a	a	NOUN
admet-276	182	28	and	and	CCONJ
admet-276	182	29	mab	mab	NOUN
admet-276	182	30	-	-	PUNCT
admet-276	182	31	b	b	NOUN
admet-276	182	32	of	of	ADP
admet-276	182	33	igg4	igg4	PROPN
admet-276	182	34	subclass	subclass	NOUN
admet-276	182	35	in	in	ADP
admet-276	182	36	cynomolgus	cynomolgus	ADJ
admet-276	182	37	monkey	monkey	NOUN
admet-276	182	38	serum	serum	NOUN
admet-276	182	39	with	with	ADP
admet-276	182	40	lloq	lloq	NOUN
admet-276	182	41	around	around	ADP
admet-276	182	42	5	5	NUM
admet-276	182	43	-	-	SYM
admet-276	182	44	25	25	NUM
admet-276	182	45	µg	µg	NOUN
admet-276	182	46	/	/	SYM
admet-276	182	47	ml	ml	NOUN
admet-276	182	48	[	[	X
admet-276	182	49	78	78	NUM
admet-276	182	50	]	]	PUNCT
admet-276	182	51	,	,	PUNCT
admet-276	182	52	which	which	PRON
admet-276	182	53	can	can	AUX
admet-276	182	54	not	not	PART
admet-276	182	55	be	be	AUX
admet-276	182	56	obtained	obtain	VERB
admet-276	182	57	by	by	ADP
admet-276	182	58	elisa	elisa	NOUN
admet-276	182	59	assay	assay	PROPN
admet-276	182	60	.	.	PUNCT
admet-276	183	1	as	as	SCONJ
admet-276	183	2	demonstrated	demonstrate	VERB
admet-276	183	3	in	in	ADP
admet-276	183	4	recent	recent	ADJ
admet-276	183	5	examples	example	NOUN
admet-276	183	6	,	,	PUNCT
admet-276	183	7	xu	xu	PROPN
admet-276	183	8	et	et	PROPN
admet-276	183	9	al	al	PROPN
admet-276	183	10	.	.	PROPN
admet-276	183	11	successfully	successfully	ADV
admet-276	183	12	applied	apply	VERB
admet-276	183	13	a	a	DET
admet-276	183	14	multiplexed	multiplexed	ADJ
admet-276	183	15	hybrid	hybrid	ADJ
admet-276	183	16	lc	lc	PROPN
admet-276	183	17	-	-	PUNCT
admet-276	183	18	ms	ms	PROPN
admet-276	183	19	/	/	SYM
admet-276	183	20	ms	ms	ADJ
admet-276	183	21	pharmacokinetic	pharmacokinetic	ADJ
admet-276	183	22	assay	assay	NOUN
admet-276	183	23	to	to	PART
admet-276	183	24	measure	measure	VERB
admet-276	183	25	two	two	NUM
admet-276	183	26	co	co	ADJ
admet-276	183	27	-	-	ADJ
admet-276	183	28	administrated	administrate	VERB
admet-276	183	29	mabs	mab	NOUN
admet-276	183	30	in	in	ADP
admet-276	183	31	a	a	DET
admet-276	183	32	clinical	clinical	ADJ
admet-276	183	33	study	study	NOUN
admet-276	183	34	without	without	ADP
admet-276	183	35	requiring	require	VERB
admet-276	183	36	admet	admet	PROPN
admet-276	183	37	&	&	CCONJ
admet-276	183	38	dmpk	dmpk	PROPN
admet-276	183	39	4(1	4(1	NOUN
admet-276	183	40	)	)	PUNCT
admet-276	183	41	(	(	PUNCT
admet-276	183	42	2016	2016	NUM
admet-276	183	43	)	)	PUNCT
admet-276	183	44	1	1	NUM
admet-276	183	45	-	-	SYM
admet-276	183	46	22	22	NUM
admet-276	183	47	adme	adme	NOUN
admet-276	183	48	testing	testing	NOUN
admet-276	183	49	of	of	ADP
admet-276	183	50	large	large	ADJ
admet-276	183	51	biologics	biologic	NOUN
admet-276	183	52	doi	doi	NOUN
admet-276	183	53	:	:	PUNCT
admet-276	183	54	10.5599	10.5599	NUM
admet-276	183	55	/	/	SYM
admet-276	183	56	admet.4.1.276	admet.4.1.276	NOUN
admet-276	183	57	11	11	NUM
admet-276	183	58	stringent	stringent	ADJ
admet-276	183	59	affinity	affinity	NOUN
admet-276	183	60	capture	capture	NOUN
admet-276	183	61	reagents	reagent	NOUN
admet-276	183	62	[	[	X
admet-276	183	63	79	79	NUM
admet-276	183	64	]	]	PUNCT
admet-276	183	65	.	.	PUNCT
admet-276	184	1	lebert	lebert	PROPN
admet-276	184	2	and	and	CCONJ
admet-276	184	3	coworkers	coworker	NOUN
admet-276	184	4	also	also	ADV
admet-276	184	5	demonstrated	demonstrate	VERB
admet-276	184	6	absolute	absolute	ADJ
admet-276	184	7	and	and	CCONJ
admet-276	184	8	multiplexed	multiplexed	ADJ
admet-276	184	9	lc	lc	PROPN
admet-276	184	10	-	-	PUNCT
admet-276	184	11	ms	ms	PROPN
admet-276	184	12	/	/	SYM
admet-276	184	13	ms	ms	PROPN
admet-276	184	14	method	method	NOUN
admet-276	184	15	combining	combine	VERB
admet-276	184	16	a	a	DET
admet-276	184	17	strategy	strategy	NOUN
admet-276	184	18	so	so	ADV
admet-276	184	19	-	-	PUNCT
admet-276	184	20	called	call	VERB
admet-276	184	21	psaqtm	psaqtm	NOUN
admet-276	184	22	(	(	PUNCT
admet-276	184	23	protein	protein	NOUN
admet-276	184	24	standard	standard	ADJ
admet-276	184	25	absolute	absolute	ADJ
admet-276	184	26	quantification	quantification	NOUN
admet-276	184	27	or	or	CCONJ
admet-276	184	28	stable	stable	ADJ
admet-276	184	29	isotopically	isotopically	ADV
admet-276	184	30	-	-	PUNCT
admet-276	184	31	labeled	label	VERB
admet-276	184	32	full	full	ADJ
admet-276	184	33	-	-	PUNCT
admet-276	184	34	length	length	NOUN
admet-276	184	35	mabs	mab	NOUN
admet-276	184	36	)	)	PUNCT
admet-276	184	37	as	as	ADP
admet-276	184	38	the	the	DET
admet-276	184	39	iss	iss	PROPN
admet-276	184	40	for	for	ADP
admet-276	184	41	quantification	quantification	NOUN
admet-276	184	42	of	of	ADP
admet-276	184	43	three	three	NUM
admet-276	184	44	mabs	mab	NOUN
admet-276	184	45	variants	variant	NOUN
admet-276	184	46	with	with	ADP
admet-276	184	47	very	very	ADV
admet-276	184	48	similar	similar	ADJ
admet-276	184	49	sequences	sequence	NOUN
admet-276	184	50	,	,	PUNCT
admet-276	184	51	e.g.	e.g.	ADV
admet-276	184	52	,	,	PUNCT
admet-276	184	53	igg1	igg1	PROPN
admet-276	184	54	,	,	PUNCT
admet-276	184	55	igg2	igg2	PROPN
admet-276	184	56	and	and	CCONJ
admet-276	184	57	igg4	igg4	PROPN
admet-276	184	58	isotypes	isotype	NOUN
admet-276	184	59	of	of	ADP
admet-276	184	60	a	a	DET
admet-276	184	61	lead	lead	NOUN
admet-276	184	62	mab	mab	NOUN
admet-276	184	63	in	in	ADP
admet-276	184	64	rat	rat	NOUN
admet-276	184	65	serum	serum	NOUN
admet-276	184	66	,	,	PUNCT
admet-276	184	67	which	which	PRON
admet-276	184	68	can	can	AUX
admet-276	184	69	be	be	AUX
admet-276	184	70	employed	employ	VERB
admet-276	184	71	for	for	ADP
admet-276	184	72	both	both	CCONJ
admet-276	184	73	preclinical	preclinical	ADJ
admet-276	184	74	and	and	CCONJ
admet-276	184	75	clinical	clinical	ADJ
admet-276	184	76	studies	study	NOUN
admet-276	184	77	[	[	X
admet-276	184	78	80	80	NUM
admet-276	184	79	]	]	PUNCT
admet-276	184	80	.	.	PUNCT
admet-276	185	1	moreover	moreover	ADV
admet-276	185	2	,	,	PUNCT
admet-276	185	3	a	a	DET
admet-276	185	4	versatile	versatile	ADJ
admet-276	185	5	immunoaffinity	immunoaffinity	NOUN
admet-276	185	6	lc	lc	PROPN
admet-276	185	7	-	-	PUNCT
admet-276	185	8	ms	ms	PROPN
admet-276	185	9	/	/	SYM
admet-276	185	10	ms	ms	PROPN
admet-276	185	11	method	method	NOUN
admet-276	185	12	was	be	AUX
admet-276	185	13	developed	develop	VERB
admet-276	185	14	to	to	PART
admet-276	185	15	quantify	quantify	VERB
admet-276	185	16	total	total	ADJ
admet-276	185	17	receptor	receptor	NOUN
admet-276	185	18	activator	activator	NOUN
admet-276	185	19	of	of	ADP
admet-276	185	20	nuclear	nuclear	ADJ
admet-276	185	21	factor	factor	NOUN
admet-276	185	22	-	-	PUNCT
admet-276	185	23	kappab	kappab	NOUN
admet-276	185	24	ligand	ligand	NOUN
admet-276	185	25	(	(	PUNCT
admet-276	185	26	rankl	rankl	PROPN
admet-276	185	27	)	)	PUNCT
admet-276	185	28	in	in	ADP
admet-276	185	29	the	the	DET
admet-276	185	30	presence	presence	NOUN
admet-276	185	31	of	of	ADP
admet-276	185	32	denosumab	denosumab	NOUN
admet-276	185	33	,	,	PUNCT
admet-276	185	34	a	a	DET
admet-276	185	35	humanized	humanize	VERB
admet-276	185	36	monoclonal	monoclonal	NOUN
admet-276	185	37	antibody	antibody	NOUN
admet-276	185	38	(	(	PUNCT
admet-276	185	39	mab	mab	NOUN
admet-276	185	40	)	)	PUNCT
admet-276	185	41	specific	specific	ADJ
admet-276	185	42	to	to	PART
admet-276	185	43	rankl	rankl	VERB
admet-276	185	44	with	with	ADP
admet-276	185	45	an	an	DET
admet-276	185	46	lloq	lloq	NOUN
admet-276	185	47	of	of	ADP
admet-276	185	48	rankl	rankl	NOUN
admet-276	185	49	down	down	ADP
admet-276	185	50	to	to	ADP
admet-276	185	51	3.13	3.13	NUM
admet-276	185	52	ng	ng	PROPN
admet-276	185	53	/	/	SYM
admet-276	185	54	ml	ml	X
admet-276	185	55	for	for	ADP
admet-276	185	56	mouse	mouse	NOUN
admet-276	185	57	plasma	plasma	NOUN
admet-276	185	58	pk	pk	NOUN
admet-276	185	59	,	,	PUNCT
admet-276	185	60	which	which	PRON
admet-276	185	61	was	be	AUX
admet-276	185	62	not	not	PART
admet-276	185	63	able	able	ADJ
admet-276	185	64	to	to	PART
admet-276	185	65	determine	determine	VERB
admet-276	185	66	the	the	DET
admet-276	185	67	total	total	ADJ
admet-276	185	68	rankl	rankl	NOUN
admet-276	185	69	because	because	SCONJ
admet-276	185	70	the	the	DET
admet-276	185	71	interference	interference	NOUN
admet-276	185	72	of	of	ADP
admet-276	185	73	denosumab	denosumab	NOUN
admet-276	185	74	decreased	decrease	VERB
admet-276	185	75	the	the	DET
admet-276	185	76	recovery	recovery	NOUN
admet-276	185	77	of	of	ADP
admet-276	185	78	rankl	rankl	NOUN
admet-276	185	79	with	with	ADP
admet-276	185	80	commercial	commercial	ADJ
admet-276	185	81	elisa	elisa	NOUN
admet-276	185	82	kit	kit	NOUN
admet-276	186	1	[	[	X
admet-276	186	2	81	81	NUM
admet-276	186	3	]	]	PUNCT
admet-276	186	4	.	.	PUNCT
admet-276	187	1	additionally	additionally	ADV
admet-276	187	2	,	,	PUNCT
admet-276	187	3	2d	2d	NOUN
admet-276	187	4	-	-	PUNCT
admet-276	187	5	lc	lc	NOUN
admet-276	187	6	(	(	PUNCT
admet-276	187	7	lc×lc)–ms	lc×lc)–ms	PROPN
admet-276	187	8	/	/	SYM
admet-276	187	9	ms	ms	PROPN
admet-276	187	10	methodology	methodology	NOUN
admet-276	187	11	with	with	ADP
admet-276	187	12	improved	improve	VERB
admet-276	187	13	ms	ms	NOUN
admet-276	187	14	detection	detection	NOUN
admet-276	187	15	limit	limit	NOUN
admet-276	187	16	of	of	ADP
admet-276	187	17	approximately	approximately	ADV
admet-276	187	18	two	two	NUM
admet-276	187	19	orders	order	NOUN
admet-276	187	20	of	of	ADP
admet-276	187	21	magnitude	magnitude	NOUN
admet-276	187	22	over	over	ADP
admet-276	187	23	direct	direct	ADJ
admet-276	187	24	lc	lc	PROPN
admet-276	187	25	–	–	PUNCT
admet-276	187	26	ms	ms	PROPN
admet-276	187	27	/	/	SYM
admet-276	187	28	ms	ms	PROPN
admet-276	187	29	was	be	AUX
admet-276	187	30	recommended	recommend	VERB
admet-276	187	31	[	[	X
admet-276	187	32	82	82	NUM
admet-276	187	33	]	]	PUNCT
admet-276	187	34	,	,	PUNCT
admet-276	187	35	as	as	ADV
admet-276	187	36	well	well	ADV
admet-276	187	37	as	as	ADP
admet-276	187	38	other	other	ADJ
admet-276	187	39	lc	lc	PROPN
admet-276	187	40	-	-	PUNCT
admet-276	187	41	ms	ms	NOUN
admet-276	187	42	formats	format	NOUN
admet-276	187	43	and	and	CCONJ
admet-276	187	44	approaches	approach	NOUN
admet-276	187	45	such	such	ADJ
admet-276	187	46	as	as	ADP
admet-276	187	47	capillary	capillary	ADJ
admet-276	187	48	lc	lc	NOUN
admet-276	187	49	-	-	PUNCT
admet-276	187	50	ms	ms	NOUN
admet-276	187	51	gaining	gain	VERB
admet-276	187	52	ms	ms	NOUN
admet-276	187	53	sensitivity	sensitivity	NOUN
admet-276	187	54	were	be	AUX
admet-276	187	55	reviewed	review	VERB
admet-276	187	56	[	[	PUNCT
admet-276	187	57	66	66	NUM
admet-276	187	58	]	]	PUNCT
admet-276	187	59	,	,	PUNCT
admet-276	187	60	offering	offer	VERB
admet-276	187	61	new	new	ADJ
admet-276	187	62	opportunities	opportunity	NOUN
admet-276	187	63	in	in	ADP
admet-276	187	64	the	the	DET
admet-276	187	65	analysis	analysis	NOUN
admet-276	187	66	of	of	ADP
admet-276	187	67	monoclonal	monoclonal	NOUN
admet-276	187	68	antibodies	antibodie	VERB
admet-276	187	69	.	.	PUNCT
admet-276	188	1	on	on	ADP
admet-276	188	2	the	the	DET
admet-276	188	3	other	other	ADJ
admet-276	188	4	hand	hand	NOUN
admet-276	188	5	,	,	PUNCT
admet-276	188	6	mass	mass	ADJ
admet-276	188	7	spectrometry	spectrometry	NOUN
admet-276	188	8	methods	method	NOUN
admet-276	188	9	(	(	PUNCT
admet-276	188	10	maldi	maldi	NOUN
admet-276	188	11	-	-	PUNCT
admet-276	188	12	tof	tof	PROPN
admet-276	188	13	,	,	PUNCT
admet-276	188	14	q	q	NOUN
admet-276	188	15	-	-	PUNCT
admet-276	188	16	tof	tof	ADJ
admet-276	188	17	,	,	PUNCT
admet-276	188	18	ltq	ltq	NOUN
admet-276	188	19	-	-	PUNCT
admet-276	188	20	orbitrap	orbitrap	NOUN
admet-276	188	21	)	)	PUNCT
admet-276	188	22	have	have	AUX
admet-276	188	23	been	be	AUX
admet-276	188	24	reported	report	VERB
admet-276	188	25	for	for	ADP
admet-276	188	26	metabolite	metabolite	NOUN
admet-276	188	27	identification	identification	NOUN
admet-276	188	28	or	or	CCONJ
admet-276	188	29	profiling	profiling	NOUN
admet-276	188	30	(	(	PUNCT
admet-276	188	31	metid	metid	NOUN
admet-276	188	32	)	)	PUNCT
admet-276	188	33	(	(	PUNCT
admet-276	188	34	e.g.	e.g.	ADV
admet-276	188	35	deamidation	deamidation	NOUN
admet-276	188	36	of	of	ADP
admet-276	188	37	asparaginyl	asparaginyl	NOUN
admet-276	188	38	and	and	CCONJ
admet-276	188	39	glutaminyl	glutaminyl	ADJ
admet-276	188	40	residues	residue	NOUN
admet-276	188	41	)	)	PUNCT
admet-276	188	42	,	,	PUNCT
admet-276	188	43	preclinical	preclinical	ADJ
admet-276	188	44	and	and	CCONJ
admet-276	188	45	clinical	clinical	ADJ
admet-276	188	46	pk	pk	NOUN
admet-276	188	47	/	/	SYM
admet-276	188	48	tk	tk	PROPN
admet-276	188	49	studies	study	NOUN
admet-276	188	50	with	with	ADP
admet-276	188	51	no	no	DET
admet-276	188	52	cross	cross	NOUN
admet-276	188	53	-	-	NOUN
admet-276	188	54	reaction	reaction	ADJ
admet-276	188	55	[	[	X
admet-276	188	56	61	61	NUM
admet-276	188	57	]	]	PUNCT
admet-276	188	58	.	.	PUNCT
admet-276	189	1	direct	direct	ADJ
admet-276	189	2	analysis	analysis	NOUN
admet-276	189	3	of	of	ADP
admet-276	189	4	therapeutic	therapeutic	ADJ
admet-276	189	5	monoclonal	monoclonal	NOUN
admet-276	189	6	antibodies	antibodie	VERB
admet-276	189	7	,	,	PUNCT
admet-276	189	8	without	without	ADP
admet-276	189	9	size	size	NOUN
admet-276	189	10	reduction	reduction	NOUN
admet-276	189	11	through	through	ADP
admet-276	189	12	enzyme	enzyme	NOUN
admet-276	189	13	digestion	digestion	NOUN
admet-276	189	14	,	,	PUNCT
admet-276	189	15	is	be	AUX
admet-276	189	16	more	more	ADV
admet-276	189	17	challenging	challenging	ADJ
admet-276	189	18	since	since	SCONJ
admet-276	189	19	these	these	DET
admet-276	189	20	molecules	molecule	NOUN
admet-276	189	21	may	may	AUX
admet-276	189	22	have	have	VERB
admet-276	189	23	a	a	DET
admet-276	189	24	molecular	molecular	ADJ
admet-276	189	25	weight	weight	NOUN
admet-276	189	26	up	up	ADP
admet-276	189	27	to	to	PART
admet-276	189	28	150	150	NUM
admet-276	189	29	kda	kda	NOUN
admet-276	189	30	,	,	PUNCT
admet-276	189	31	forming	form	VERB
admet-276	189	32	a	a	DET
admet-276	189	33	large	large	ADJ
admet-276	189	34	distribution	distribution	NOUN
admet-276	189	35	of	of	ADP
admet-276	189	36	charge	charge	NOUN
admet-276	189	37	states	state	NOUN
admet-276	189	38	during	during	ADP
admet-276	189	39	electrospray	electrospray	ADJ
admet-276	189	40	ionization	ionization	NOUN
admet-276	189	41	(	(	PUNCT
admet-276	189	42	esi	esi	NOUN
admet-276	189	43	)	)	PUNCT
admet-276	189	44	,	,	PUNCT
admet-276	189	45	thus	thus	ADV
admet-276	189	46	resulting	result	VERB
admet-276	189	47	in	in	ADP
admet-276	189	48	a	a	DET
admet-276	189	49	complex	complex	ADJ
admet-276	189	50	mass	mass	NOUN
admet-276	189	51	spectrum	spectrum	NOUN
admet-276	189	52	with	with	ADP
admet-276	189	53	decreased	decrease	VERB
admet-276	189	54	sensitivity	sensitivity	NOUN
admet-276	189	55	.	.	PUNCT
admet-276	190	1	to	to	PART
admet-276	190	2	overcome	overcome	VERB
admet-276	190	3	these	these	DET
admet-276	190	4	difficulties	difficulty	NOUN
admet-276	190	5	,	,	PUNCT
admet-276	190	6	the	the	DET
admet-276	190	7	strategy	strategy	NOUN
admet-276	190	8	consists	consist	VERB
admet-276	190	9	of	of	ADP
admet-276	190	10	decreasing	decrease	VERB
admet-276	190	11	their	their	PRON
admet-276	190	12	size	size	NOUN
admet-276	190	13	by	by	ADP
admet-276	190	14	proteolytic	proteolytic	ADJ
admet-276	190	15	digestion	digestion	NOUN
admet-276	190	16	in	in	ADP
admet-276	190	17	order	order	NOUN
admet-276	190	18	to	to	PART
admet-276	190	19	form	form	VERB
admet-276	190	20	1000	1000	NUM
admet-276	190	21	to	to	ADP
admet-276	190	22	2000	2000	NUM
admet-276	190	23	da	da	NOUN
admet-276	190	24	peptides	peptide	NOUN
admet-276	190	25	with	with	ADP
admet-276	190	26	few	few	ADJ
admet-276	190	27	charge	charge	NOUN
admet-276	190	28	states	state	NOUN
admet-276	190	29	(	(	PUNCT
admet-276	190	30	between	between	ADP
admet-276	190	31	2	2	NUM
admet-276	190	32	and	and	CCONJ
admet-276	190	33	4	4	NUM
admet-276	190	34	)	)	PUNCT
admet-276	190	35	which	which	PRON
admet-276	190	36	can	can	AUX
admet-276	190	37	be	be	AUX
admet-276	190	38	readily	readily	ADV
admet-276	190	39	quantified	quantify	VERB
admet-276	190	40	in	in	ADP
admet-276	190	41	mrm	mrm	PROPN
admet-276	190	42	mode	mode	PROPN
admet-276	190	43	on	on	ADP
admet-276	190	44	esi	esi	ADJ
admet-276	190	45	-	-	ADJ
admet-276	190	46	mass	mass	ADJ
admet-276	190	47	spectrometers	spectrometer	NOUN
admet-276	190	48	.	.	PUNCT
admet-276	191	1	in	in	ADP
admet-276	191	2	another	another	DET
admet-276	191	3	recent	recent	ADJ
admet-276	191	4	protocol	protocol	NOUN
admet-276	191	5	,	,	PUNCT
admet-276	191	6	detailed	detailed	ADJ
admet-276	191	7	mass	mass	ADJ
admet-276	191	8	analysis	analysis	NOUN
admet-276	191	9	of	of	ADP
admet-276	191	10	structural	structural	ADJ
admet-276	191	11	heterogeneity	heterogeneity	NOUN
admet-276	191	12	in	in	ADP
admet-276	191	13	monoclonal	monoclonal	NOUN
admet-276	191	14	antibodies	antibody	NOUN
admet-276	191	15	at	at	ADP
admet-276	191	16	the	the	DET
admet-276	191	17	intact	intact	ADJ
admet-276	191	18	protein	protein	NOUN
admet-276	191	19	level	level	NOUN
admet-276	191	20	under	under	ADP
admet-276	191	21	pseudo	pseudo	NOUN
admet-276	191	22	-	-	ADJ
admet-276	191	23	native	native	ADJ
admet-276	191	24	conditions	condition	NOUN
admet-276	191	25	using	use	VERB
admet-276	191	26	native	native	ADJ
admet-276	191	27	mass	mass	PROPN
admet-276	191	28	spectrometry	spectrometry	NOUN
admet-276	191	29	was	be	AUX
admet-276	191	30	reported	report	VERB
admet-276	191	31	[	[	X
admet-276	191	32	83	83	NUM
admet-276	191	33	]	]	PUNCT
admet-276	191	34	.	.	PUNCT
admet-276	192	1	this	this	DET
admet-276	192	2	method	method	NOUN
admet-276	192	3	can	can	AUX
admet-276	192	4	be	be	AUX
admet-276	192	5	used	use	VERB
admet-276	192	6	for	for	ADP
admet-276	192	7	different	different	ADJ
admet-276	192	8	applications	application	NOUN
admet-276	192	9	such	such	ADJ
admet-276	192	10	as	as	ADP
admet-276	192	11	the	the	DET
admet-276	192	12	analysis	analysis	NOUN
admet-276	192	13	of	of	ADP
admet-276	192	14	mixtures	mixture	NOUN
admet-276	192	15	of	of	ADP
admet-276	192	16	mabs	mab	NOUN
admet-276	192	17	,	,	PUNCT
admet-276	192	18	drug	drug	NOUN
admet-276	192	19	-	-	PUNCT
admet-276	192	20	antibody	antibody	NOUN
admet-276	192	21	conjugates	conjugate	NOUN
admet-276	192	22	and	and	CCONJ
admet-276	192	23	the	the	DET
admet-276	192	24	analysis	analysis	NOUN
admet-276	192	25	of	of	ADP
admet-276	192	26	mab	mab	NOUN
admet-276	192	27	ptms	ptms	NOUN
admet-276	192	28	,	,	PUNCT
admet-276	192	29	including	include	VERB
admet-276	192	30	the	the	DET
admet-276	192	31	qualitative	qualitative	ADJ
admet-276	192	32	and	and	CCONJ
admet-276	192	33	quantitative	quantitative	ADJ
admet-276	192	34	analysis	analysis	NOUN
admet-276	192	35	of	of	ADP
admet-276	192	36	mab	mab	NOUN
admet-276	192	37	glycosylation	glycosylation	NOUN
admet-276	192	38	,	,	PUNCT
admet-276	192	39	and	and	CCONJ
admet-276	192	40	it	it	PRON
admet-276	192	41	offers	offer	VERB
admet-276	192	42	several	several	ADJ
admet-276	192	43	advantages	advantage	NOUN
admet-276	192	44	in	in	ADP
admet-276	192	45	terms	term	NOUN
admet-276	192	46	of	of	ADP
admet-276	192	47	speed	speed	NOUN
admet-276	192	48	,	,	PUNCT
admet-276	192	49	sensitivity	sensitivity	NOUN
admet-276	192	50	and	and	CCONJ
admet-276	192	51	specificity	specificity	NOUN
admet-276	192	52	and	and	CCONJ
admet-276	192	53	high	high	ADJ
admet-276	192	54	-	-	PUNCT
admet-276	192	55	throughput	throughput	NOUN
admet-276	192	56	analysis	analysis	NOUN
admet-276	192	57	.	.	PUNCT
admet-276	193	1	overall	overall	ADJ
admet-276	193	2	,	,	PUNCT
admet-276	193	3	there	there	PRON
admet-276	193	4	is	be	VERB
admet-276	193	5	a	a	DET
admet-276	193	6	need	need	NOUN
admet-276	193	7	for	for	ADP
admet-276	193	8	general	general	ADJ
admet-276	193	9	and	and	CCONJ
admet-276	193	10	reliable	reliable	ADJ
admet-276	193	11	lc	lc	NOUN
admet-276	193	12	-	-	PUNCT
admet-276	193	13	ms	ms	NOUN
admet-276	193	14	assays	assay	NOUN
admet-276	193	15	capable	capable	ADJ
admet-276	193	16	of	of	ADP
admet-276	193	17	supporting	support	VERB
admet-276	193	18	the	the	DET
admet-276	193	19	bioanalysis	bioanalysis	NOUN
admet-276	193	20	of	of	ADP
admet-276	193	21	a	a	DET
admet-276	193	22	variety	variety	NOUN
admet-276	193	23	of	of	ADP
admet-276	193	24	human	human	ADJ
admet-276	193	25	monoclonal	monoclonal	NOUN
admet-276	193	26	antibodybased	antibodybase	VERB
admet-276	193	27	therapeutics	therapeutic	NOUN
admet-276	193	28	such	such	ADJ
admet-276	193	29	as	as	ADP
admet-276	193	30	reported	report	VERB
admet-276	193	31	universal	universal	ADJ
admet-276	193	32	peptide	peptide	NOUN
admet-276	193	33	approach	approach	NOUN
admet-276	193	34	to	to	ADP
admet-276	193	35	the	the	DET
admet-276	193	36	bioanalysis	bioanalysis	NOUN
admet-276	193	37	of	of	ADP
admet-276	193	38	human	human	ADJ
admet-276	193	39	monoclonal	monoclonal	NOUN
admet-276	193	40	antibody	antibody	NOUN
admet-276	193	41	protein	protein	NOUN
admet-276	193	42	drug	drug	NOUN
admet-276	193	43	candidates	candidate	NOUN
admet-276	193	44	in	in	ADP
admet-276	193	45	animal	animal	NOUN
admet-276	193	46	pk	pk	PROPN
admet-276	193	47	/	/	SYM
admet-276	193	48	tk	tk	PROPN
admet-276	193	49	studies	study	NOUN
admet-276	193	50	[	[	X
admet-276	193	51	84	84	NUM
admet-276	193	52	]	]	SYM
admet-276	193	53	.	.	PUNCT
admet-276	194	1	3.3	3.3	NUM
admet-276	194	2	lc	lc	PROPN
admet-276	194	3	-	-	PUNCT
admet-276	194	4	ms	ms	PROPN
admet-276	194	5	/	/	SYM
admet-276	194	6	ms	ms	PROPN
admet-276	194	7	and	and	CCONJ
admet-276	194	8	bla	bla	NOUN
admet-276	194	9	bioanalysis	bioanalysis	NOUN
admet-276	194	10	of	of	ADP
admet-276	194	11	adcs	adcs	NOUN
admet-276	194	12	due	due	ADP
admet-276	194	13	to	to	ADP
admet-276	194	14	the	the	DET
admet-276	194	15	fact	fact	NOUN
admet-276	194	16	that	that	SCONJ
admet-276	194	17	the	the	DET
admet-276	194	18	adcs	adc	NOUN
admet-276	194	19	are	be	AUX
admet-276	194	20	complex	complex	ADJ
admet-276	194	21	mixtures	mixture	NOUN
admet-276	194	22	incorporating	incorporate	VERB
admet-276	194	23	large	large	ADJ
admet-276	194	24	and	and	CCONJ
admet-276	194	25	small	small	ADJ
admet-276	194	26	-	-	PUNCT
admet-276	194	27	molecule	molecule	NOUN
admet-276	194	28	characteristics	characteristic	NOUN
admet-276	194	29	,	,	PUNCT
admet-276	194	30	this	this	PRON
admet-276	194	31	poses	pose	VERB
admet-276	194	32	more	more	ADV
admet-276	194	33	unique	unique	ADJ
admet-276	194	34	bioanalytical	bioanalytical	ADJ
admet-276	194	35	challenges	challenge	NOUN
admet-276	194	36	for	for	ADP
admet-276	194	37	adc	adc	PROPN
admet-276	194	38	than	than	SCONJ
admet-276	194	39	mab	mab	VERB
admet-276	194	40	to	to	PART
admet-276	194	41	measure	measure	VERB
admet-276	194	42	adcs	adcs	ADJ
admet-276	194	43	and	and	CCONJ
admet-276	194	44	their	their	PRON
admet-276	194	45	catabolites	catabolite	NOUN
admet-276	194	46	in	in	ADP
admet-276	194	47	plasma	plasma	NOUN
admet-276	194	48	and	and	CCONJ
admet-276	194	49	serum	serum	NOUN
admet-276	194	50	[	[	X
admet-276	194	51	46	46	NUM
admet-276	194	52	]	]	PUNCT
admet-276	194	53	.	.	PUNCT
admet-276	195	1	these	these	DET
admet-276	195	2	challenges	challenge	NOUN
admet-276	195	3	include	include	VERB
admet-276	195	4	adc	adc	PROPN
admet-276	195	5	bioanalysis	bioanalysis	NOUN
admet-276	195	6	such	such	ADJ
admet-276	195	7	as	as	ADP
admet-276	195	8	quantifying	quantify	VERB
admet-276	195	9	adc	adc	PROPN
admet-276	195	10	and	and	CCONJ
admet-276	195	11	dar	dar	NOUN
admet-276	195	12	in	in	ADP
admet-276	195	13	serum	serum	NOUN
admet-276	195	14	/	/	SYM
admet-276	195	15	plasma	plasma	NOUN
admet-276	195	16	for	for	ADP
admet-276	195	17	pk	pk	NOUN
admet-276	195	18	studies	study	NOUN
admet-276	195	19	and	and	CCONJ
admet-276	195	20	strategies	strategy	NOUN
admet-276	195	21	for	for	ADP
admet-276	195	22	assessing	assess	VERB
admet-276	195	23	immunogenicity	immunogenicity	NOUN
admet-276	195	24	.	.	PUNCT
admet-276	196	1	since	since	SCONJ
admet-276	196	2	adc	adc	PROPN
admet-276	196	3	species	specie	NOUN
admet-276	196	4	with	with	ADP
admet-276	196	5	different	different	ADJ
admet-276	196	6	dar	dar	NOUN
admet-276	196	7	distribution	distribution	NOUN
admet-276	196	8	may	may	AUX
admet-276	196	9	display	display	VERB
admet-276	196	10	different	different	ADJ
admet-276	196	11	potencies	potency	NOUN
admet-276	196	12	,	,	PUNCT
admet-276	196	13	the	the	DET
admet-276	196	14	measured	measured	ADJ
admet-276	196	15	plasma	plasma	NOUN
admet-276	196	16	concentrations	concentration	NOUN
admet-276	196	17	may	may	AUX
admet-276	196	18	not	not	PART
admet-276	196	19	accurately	accurately	ADV
admet-276	196	20	reflect	reflect	VERB
admet-276	196	21	the	the	DET
admet-276	196	22	associated	associated	ADJ
admet-276	196	23	pd	pd	PROPN
admet-276	196	24	effect	effect	NOUN
admet-276	196	25	.	.	PUNCT
admet-276	197	1	as	as	ADP
admet-276	197	2	a	a	DET
admet-276	197	3	general	general	ADJ
admet-276	197	4	rule	rule	NOUN
admet-276	197	5	,	,	PUNCT
admet-276	197	6	both	both	DET
admet-276	197	7	total	total	ADJ
admet-276	197	8	antibody	antibody	NOUN
admet-276	197	9	assay	assay	VERB
admet-276	197	10	and	and	CCONJ
admet-276	197	11	conjugate	conjugate	ADJ
admet-276	197	12	antibody	antibody	NOUN
admet-276	197	13	assay	assay	NOUN
admet-276	197	14	based	base	VERB
admet-276	197	15	on	on	ADP
admet-276	197	16	elisa	elisa	PROPN
admet-276	197	17	are	be	AUX
admet-276	197	18	needed	need	VERB
admet-276	197	19	to	to	PART
admet-276	197	20	measure	measure	VERB
admet-276	197	21	plasma	plasma	NOUN
admet-276	197	22	concentrations	concentration	NOUN
admet-276	197	23	over	over	ADP
admet-276	197	24	the	the	DET
admet-276	197	25	time	time	NOUN
admet-276	197	26	.	.	PUNCT
admet-276	198	1	in	in	ADP
admet-276	198	2	addition	addition	NOUN
admet-276	198	3	,	,	PUNCT
admet-276	198	4	adc	adc	PROPN
admet-276	198	5	complexity	complexity	NOUN
admet-276	198	6	may	may	AUX
admet-276	198	7	increase	increase	VERB
admet-276	198	8	in	in	ADP
admet-276	198	9	in	in	ADP
admet-276	198	10	vivo	vivo	NOUN
admet-276	198	11	due	due	ADP
admet-276	198	12	to	to	ADP
admet-276	198	13	biotransformation	biotransformation	NOUN
admet-276	198	14	by	by	ADP
admet-276	198	15	catabolism	catabolism	NOUN
admet-276	198	16	or	or	CCONJ
admet-276	198	17	metabolism	metabolism	NOUN
admet-276	198	18	,	,	PUNCT
admet-276	198	19	leading	lead	VERB
admet-276	198	20	to	to	ADP
admet-276	198	21	additional	additional	ADJ
admet-276	198	22	changes	change	NOUN
admet-276	198	23	in	in	ADP
admet-276	198	24	dar	dar	NOUN
admet-276	198	25	or	or	CCONJ
admet-276	198	26	dynamically	dynamically	ADV
admet-276	198	27	changing	change	VERB
admet-276	198	28	mixtures	mixture	NOUN
admet-276	198	29	.	.	PUNCT
admet-276	199	1	therefore	therefore	ADV
admet-276	199	2	,	,	PUNCT
admet-276	199	3	a	a	DET
admet-276	199	4	standard	standard	ADJ
admet-276	199	5	calibration	calibration	NOUN
admet-276	199	6	curve	curve	NOUN
admet-276	199	7	consisting	consist	VERB
admet-276	199	8	of	of	ADP
admet-276	199	9	the	the	DET
admet-276	199	10	reference	reference	NOUN
admet-276	199	11	standard	standard	NOUN
admet-276	199	12	may	may	AUX
admet-276	199	13	not	not	PART
admet-276	199	14	be	be	AUX
admet-276	199	15	appropriate	appropriate	ADJ
admet-276	199	16	for	for	ADP
admet-276	199	17	quantification	quantification	NOUN
admet-276	199	18	of	of	ADP
admet-276	199	19	analytes	analyte	NOUN
admet-276	199	20	in	in	ADP
admet-276	199	21	vivo	vivo	NOUN
admet-276	199	22	.	.	PUNCT
admet-276	200	1	biotransformation	biotransformation	NOUN
admet-276	200	2	may	may	AUX
admet-276	200	3	result	result	VERB
admet-276	200	4	in	in	ADP
admet-276	200	5	adc	adc	PROPN
admet-276	200	6	analytes	analyte	NOUN
admet-276	200	7	in	in	ADP
admet-276	200	8	vivo	vivo	NOUN
admet-276	200	9	that	that	PRON
admet-276	200	10	differ	differ	VERB
admet-276	200	11	from	from	ADP
admet-276	200	12	those	those	PRON
admet-276	200	13	in	in	ADP
admet-276	200	14	the	the	DET
admet-276	200	15	reference	reference	NOUN
admet-276	200	16	standard	standard	NOUN
admet-276	200	17	in	in	ADP
admet-276	200	18	vitro	vitro	X
admet-276	200	19	.	.	PUNCT
admet-276	201	1	a	a	DET
admet-276	201	2	notable	notable	ADJ
admet-276	201	3	example	example	NOUN
admet-276	201	4	was	be	AUX
admet-276	201	5	characterization	characterization	NOUN
admet-276	201	6	of	of	ADP
admet-276	201	7	adc	adc	PROPN
admet-276	201	8	(	(	PUNCT
admet-276	201	9	trastuzumab	trastuzumab	NOUN
admet-276	201	10	emtansine	emtansine	NOUN
admet-276	201	11	)	)	PUNCT
admet-276	201	12	drug	drug	NOUN
admet-276	201	13	distribution	distribution	NOUN
admet-276	201	14	in	in	ADP
admet-276	201	15	a	a	DET
admet-276	201	16	cynomolgus	cynomolgus	ADJ
admet-276	201	17	monkey	monkey	NOUN
admet-276	201	18	pk	pk	NOUN
admet-276	201	19	study	study	NOUN
admet-276	201	20	by	by	ADP
admet-276	201	21	her2	her2	PROPN
admet-276	201	22	extracellular	extracellular	ADJ
admet-276	201	23	domain	domain	NOUN
admet-276	201	24	affinity	affinity	NOUN
admet-276	201	25	capture	capture	NOUN
admet-276	201	26	lc	lc	PROPN
admet-276	201	27	–	–	PUNCT
admet-276	201	28	ms	ms	NOUN
admet-276	201	29	,	,	PUNCT
admet-276	201	30	which	which	PRON
admet-276	201	31	hong	hong	PROPN
admet-276	201	32	wan	wan	PROPN
admet-276	201	33	admet	admet	PROPN
admet-276	201	34	&	&	CCONJ
admet-276	201	35	dmpk	dmpk	PROPN
admet-276	201	36	4(1	4(1	NOUN
admet-276	201	37	)	)	PUNCT
admet-276	201	38	(	(	PUNCT
admet-276	201	39	2016	2016	NUM
admet-276	201	40	)	)	PUNCT
admet-276	201	41	1	1	NUM
admet-276	201	42	-	-	SYM
admet-276	201	43	22	22	NUM
admet-276	201	44	12	12	NUM
admet-276	201	45	showed	show	VERB
admet-276	201	46	the	the	DET
admet-276	201	47	adr	adr	PROPN
admet-276	201	48	distribution	distribution	NOUN
admet-276	201	49	shifts	shift	NOUN
admet-276	201	50	to	to	PART
admet-276	201	51	lower	low	ADJ
admet-276	201	52	values	value	NOUN
admet-276	201	53	over	over	ADP
admet-276	201	54	time	time	NOUN
admet-276	201	55	,	,	PUNCT
admet-276	201	56	e.g.	e.g.	ADV
admet-276	201	57	,	,	PUNCT
admet-276	201	58	dar=2.76	dar=2.76	PROPN
admet-276	201	59	at	at	ADP
admet-276	201	60	day	day	NOUN
admet-276	201	61	1	1	NUM
admet-276	201	62	,	,	PUNCT
admet-276	201	63	1.86	1.86	NUM
admet-276	201	64	at	at	ADP
admet-276	201	65	day	day	NOUN
admet-276	201	66	10	10	NUM
admet-276	201	67	,	,	PUNCT
admet-276	201	68	0.68	0.68	NUM
admet-276	201	69	at	at	ADP
admet-276	201	70	day	day	NOUN
admet-276	201	71	28	28	NUM
admet-276	201	72	,	,	PUNCT
admet-276	201	73	respectively	respectively	ADV
admet-276	201	74	[	[	X
admet-276	201	75	46	46	NUM
admet-276	201	76	]	]	PUNCT
admet-276	201	77	.	.	PUNCT
admet-276	202	1	apparently	apparently	ADV
admet-276	202	2	,	,	PUNCT
admet-276	202	3	the	the	DET
admet-276	202	4	dar	dar	NOUN
admet-276	202	5	composition	composition	NOUN
admet-276	202	6	of	of	ADP
admet-276	202	7	adc	adc	PROPN
admet-276	202	8	in	in	ADP
admet-276	202	9	vivo	vivo	NOUN
admet-276	202	10	can	can	AUX
admet-276	202	11	vary	vary	VERB
admet-276	202	12	due	due	ADJ
admet-276	202	13	to	to	ADP
admet-276	202	14	drug	drug	NOUN
admet-276	202	15	deconjugation	deconjugation	NOUN
admet-276	202	16	or	or	CCONJ
admet-276	202	17	metabolic	metabolic	NOUN
admet-276	202	18	clearance	clearance	NOUN
admet-276	202	19	.	.	PUNCT
admet-276	203	1	therefore	therefore	ADV
admet-276	203	2	,	,	PUNCT
admet-276	203	3	it	it	PRON
admet-276	203	4	is	be	AUX
admet-276	203	5	important	important	ADJ
admet-276	203	6	to	to	PART
admet-276	203	7	assess	assess	VERB
admet-276	203	8	the	the	DET
admet-276	203	9	reference	reference	NOUN
admet-276	203	10	standard	standard	ADJ
admet-276	203	11	calibration	calibration	NOUN
admet-276	203	12	curve	curve	NOUN
admet-276	203	13	appropriately	appropriately	ADV
admet-276	203	14	for	for	ADP
admet-276	203	15	all	all	DET
admet-276	203	16	pk	pk	NOUN
admet-276	203	17	time	time	NOUN
admet-276	203	18	points	point	NOUN
admet-276	203	19	to	to	PART
admet-276	203	20	gain	gain	VERB
admet-276	203	21	accurate	accurate	ADJ
admet-276	203	22	dar	dar	NOUN
admet-276	203	23	and	and	CCONJ
admet-276	203	24	pk	pk	NOUN
admet-276	203	25	data	datum	NOUN
admet-276	203	26	for	for	ADP
admet-276	203	27	a	a	DET
admet-276	203	28	better	well	ADJ
admet-276	203	29	understanding	understanding	NOUN
admet-276	203	30	of	of	ADP
admet-276	203	31	pd	pd	PROPN
admet-276	203	32	effect	effect	NOUN
admet-276	203	33	.	.	PUNCT
admet-276	204	1	in	in	ADP
admet-276	204	2	this	this	DET
admet-276	204	3	case	case	NOUN
admet-276	204	4	,	,	PUNCT
admet-276	204	5	as	as	SCONJ
admet-276	204	6	suggested	suggest	VERB
admet-276	204	7	by	by	ADP
admet-276	204	8	the	the	DET
admet-276	204	9	adc	adc	PROPN
admet-276	204	10	working	working	NOUN
admet-276	204	11	group	group	NOUN
admet-276	204	12	of	of	ADP
admet-276	204	13	aaps	aap	NOUN
admet-276	204	14	and	and	CCONJ
admet-276	204	15	genentech	genentech	NOUN
admet-276	204	16	scientists	scientist	NOUN
admet-276	204	17	,	,	PUNCT
admet-276	204	18	a	a	DET
admet-276	204	19	comparative	comparative	ADJ
admet-276	204	20	analysis	analysis	NOUN
admet-276	204	21	of	of	ADP
admet-276	204	22	assay	assay	ADJ
admet-276	204	23	performance	performance	NOUN
admet-276	204	24	for	for	ADP
admet-276	204	25	samples	sample	NOUN
admet-276	204	26	prepared	prepare	VERB
admet-276	204	27	with	with	ADP
admet-276	204	28	unconjugated	unconjugated	ADJ
admet-276	204	29	antibody	antibody	NOUN
admet-276	204	30	and	and	CCONJ
admet-276	204	31	samples	sample	NOUN
admet-276	204	32	prepared	prepare	VERB
admet-276	204	33	with	with	ADP
admet-276	204	34	adc	adc	PROPN
admet-276	204	35	preparations	preparation	NOUN
admet-276	204	36	with	with	ADP
admet-276	204	37	varying	vary	VERB
admet-276	204	38	dar	dar	NOUN
admet-276	204	39	values	value	NOUN
admet-276	204	40	may	may	AUX
admet-276	204	41	be	be	AUX
admet-276	204	42	conducted	conduct	VERB
admet-276	204	43	[	[	X
admet-276	204	44	46,62	46,62	NOUN
admet-276	204	45	]	]	PUNCT
admet-276	204	46	.	.	PUNCT
admet-276	205	1	both	both	DET
admet-276	205	2	types	type	NOUN
admet-276	205	3	of	of	ADP
admet-276	205	4	qc	qc	PROPN
admet-276	205	5	samples	sample	NOUN
admet-276	205	6	should	should	AUX
admet-276	205	7	ideally	ideally	ADV
admet-276	205	8	produce	produce	VERB
admet-276	205	9	back	back	ADV
admet-276	205	10	-	-	PUNCT
admet-276	205	11	calculated	calculate	VERB
admet-276	205	12	concentrations	concentration	NOUN
admet-276	205	13	within	within	ADP
admet-276	205	14	the	the	DET
admet-276	205	15	expected	expect	VERB
admet-276	205	16	acceptable	acceptable	ADJ
admet-276	205	17	range	range	NOUN
admet-276	205	18	of	of	ADP
admet-276	205	19	the	the	DET
admet-276	205	20	assay	assay	NOUN
admet-276	205	21	(	(	PUNCT
admet-276	205	22	e.g.	e.g.	ADV
admet-276	205	23	,	,	PUNCT
admet-276	205	24	±20	±20	PROPN
admet-276	205	25	%	%	NOUN
admet-276	205	26	)	)	PUNCT
admet-276	205	27	.	.	PUNCT
admet-276	206	1	in	in	ADP
admet-276	206	2	addition	addition	NOUN
admet-276	206	3	,	,	PUNCT
admet-276	206	4	recoveries	recovery	NOUN
admet-276	206	5	for	for	ADP
admet-276	206	6	qc	qc	PROPN
admet-276	206	7	samples	sample	NOUN
admet-276	206	8	generated	generate	VERB
admet-276	206	9	using	use	VERB
admet-276	206	10	unconjugated	unconjugated	ADJ
admet-276	206	11	antibody	antibody	NOUN
admet-276	206	12	and	and	CCONJ
admet-276	206	13	adc	adc	PROPN
admet-276	206	14	preparations	preparation	NOUN
admet-276	206	15	with	with	ADP
admet-276	206	16	varying	vary	VERB
admet-276	206	17	dar	dar	NOUN
admet-276	206	18	values	value	NOUN
admet-276	206	19	may	may	AUX
admet-276	206	20	be	be	AUX
admet-276	206	21	compared	compare	VERB
admet-276	206	22	[	[	X
admet-276	206	23	62	62	NUM
admet-276	206	24	]	]	PUNCT
admet-276	206	25	.	.	PUNCT
admet-276	207	1	likewise	likewise	ADV
admet-276	207	2	,	,	PUNCT
admet-276	207	3	dere	dere	VERB
admet-276	207	4	et	et	PROPN
admet-276	207	5	al	al	PROPN
admet-276	207	6	.	.	PROPN
admet-276	207	7	demonstrated	demonstrate	VERB
admet-276	207	8	a	a	DET
admet-276	207	9	comparison	comparison	NOUN
admet-276	207	10	of	of	ADP
admet-276	207	11	serum	serum	PROPN
admet-276	207	12	t	t	PROPN
admet-276	207	13	-	-	PUNCT
admet-276	207	14	dm1	dm1	PROPN
admet-276	207	15	concentrations	concentration	NOUN
admet-276	207	16	obtained	obtain	VERB
admet-276	207	17	by	by	ADP
admet-276	207	18	using	use	VERB
admet-276	207	19	the	the	DET
admet-276	207	20	total	total	ADJ
admet-276	207	21	-	-	PUNCT
admet-276	207	22	trastuzumab	trastuzumab	NOUN
admet-276	207	23	and	and	CCONJ
admet-276	207	24	conjugated	conjugated	ADJ
admet-276	207	25	-	-	PUNCT
admet-276	207	26	trastuzumab	trastuzumab	NOUN
admet-276	207	27	elisa	elisa	NOUN
admet-276	207	28	assays	assay	NOUN
admet-276	207	29	using	use	VERB
admet-276	207	30	the	the	DET
admet-276	207	31	t	t	PROPN
admet-276	207	32	-	-	PUNCT
admet-276	207	33	dm1	dm1	PROPN
admet-276	207	34	as	as	ADP
admet-276	207	35	the	the	DET
admet-276	207	36	reference	reference	NOUN
admet-276	207	37	standard	standard	NOUN
admet-276	207	38	,	,	PUNCT
admet-276	207	39	which	which	PRON
admet-276	207	40	showed	show	VERB
admet-276	207	41	an	an	DET
admet-276	207	42	excellent	excellent	ADJ
admet-276	207	43	linear	linear	NOUN
admet-276	207	44	regression	regression	NOUN
admet-276	207	45	(	(	PUNCT
admet-276	207	46	r2=0.995	r2=0.995	NUM
admet-276	207	47	and	and	CCONJ
admet-276	207	48	a	a	DET
admet-276	207	49	slope	slope	NOUN
admet-276	207	50	=	=	NOUN
admet-276	207	51	1.04	1.04	NUM
admet-276	207	52	)	)	PUNCT
admet-276	208	1	[	[	X
admet-276	208	2	60	60	NUM
admet-276	208	3	]	]	PUNCT
admet-276	208	4	.	.	PUNCT
admet-276	209	1	often	often	ADV
admet-276	209	2	diverse	diverse	ADJ
admet-276	209	3	bioanalytical	bioanalytical	ADJ
admet-276	209	4	methods	method	NOUN
admet-276	209	5	,	,	PUNCT
admet-276	209	6	a	a	DET
admet-276	209	7	combination	combination	NOUN
admet-276	209	8	of	of	ADP
admet-276	209	9	lba	lba	PROPN
admet-276	209	10	,	,	PUNCT
admet-276	209	11	high	high	ADJ
admet-276	209	12	resolution	resolution	NOUN
admet-276	209	13	lc	lc	PROPN
admet-276	209	14	-	-	PUNCT
admet-276	209	15	ms	ms	NOUN
admet-276	209	16	and	and	CCONJ
admet-276	209	17	high	high	ADJ
admet-276	209	18	sensitive	sensitive	ADJ
admet-276	209	19	lcms	lcms	PROPN
admet-276	209	20	/	/	SYM
admet-276	209	21	ms	ms	PROPN
admet-276	209	22	method	method	NOUN
admet-276	209	23	,	,	PUNCT
admet-276	209	24	are	be	AUX
admet-276	209	25	applied	apply	VERB
admet-276	209	26	to	to	PART
admet-276	209	27	measure	measure	VERB
admet-276	209	28	adc	adc	PROPN
admet-276	209	29	related	related	ADJ
admet-276	209	30	analytes	analyte	NOUN
admet-276	209	31	such	such	ADJ
admet-276	209	32	as	as	ADP
admet-276	209	33	drugantibody	drugantibody	NOUN
admet-276	209	34	conjugate	conjugate	NOUN
admet-276	209	35	,	,	PUNCT
admet-276	209	36	unconjugated	unconjugated	ADJ
admet-276	209	37	antibody	antibody	NOUN
admet-276	209	38	and	and	CCONJ
admet-276	209	39	free	free	ADJ
admet-276	209	40	toxin	toxin	NOUN
admet-276	209	41	as	as	ADV
admet-276	209	42	well	well	ADV
admet-276	209	43	as	as	ADP
admet-276	209	44	metabolite	metabolite	NOUN
admet-276	209	45	/	/	SYM
admet-276	209	46	catabolites	catabolite	NOUN
admet-276	209	47	.	.	PUNCT
admet-276	210	1	selecting	select	VERB
admet-276	210	2	the	the	DET
admet-276	210	3	appropriate	appropriate	ADJ
admet-276	210	4	lcms	lcms	PROPN
admet-276	210	5	/	/	SYM
admet-276	210	6	ms	ms	PROPN
admet-276	210	7	method	method	NOUN
admet-276	210	8	of	of	ADP
admet-276	210	9	a	a	DET
admet-276	210	10	large	large	ADJ
admet-276	210	11	molecule	molecule	NOUN
admet-276	210	12	largely	largely	ADV
admet-276	210	13	depends	depend	VERB
admet-276	210	14	on	on	ADP
admet-276	210	15	its	its	PRON
admet-276	210	16	molecular	molecular	ADJ
admet-276	210	17	features	feature	NOUN
admet-276	210	18	and	and	CCONJ
admet-276	210	19	the	the	DET
admet-276	210	20	required	require	VERB
admet-276	210	21	assay	assay	NOUN
admet-276	210	22	sensitivity	sensitivity	NOUN
admet-276	210	23	or	or	CCONJ
admet-276	210	24	expected	expect	VERB
admet-276	210	25	concentration	concentration	NOUN
admet-276	210	26	range	range	NOUN
admet-276	210	27	in	in	ADP
admet-276	210	28	the	the	DET
admet-276	210	29	sample	sample	NOUN
admet-276	210	30	matrix	matrix	NOUN
admet-276	210	31	to	to	PART
admet-276	210	32	be	be	AUX
admet-276	210	33	analyzed	analyze	VERB
admet-276	210	34	.	.	PUNCT
admet-276	211	1	the	the	DET
admet-276	211	2	affinity	affinity	NOUN
admet-276	211	3	capture	capture	NOUN
admet-276	211	4	lc	lc	PROPN
admet-276	211	5	-	-	PUNCT
admet-276	211	6	ms	ms	NOUN
admet-276	211	7	and	and	CCONJ
admet-276	211	8	affinity	affinity	NOUN
admet-276	211	9	capture	capture	VERB
admet-276	211	10	hydrophobic	hydrophobic	NOUN
admet-276	211	11	interaction	interaction	NOUN
admet-276	211	12	chromatography	chromatography	NOUN
admet-276	211	13	(	(	PUNCT
admet-276	211	14	hic	hic	ADJ
admet-276	211	15	)	)	PUNCT
admet-276	211	16	methods	method	NOUN
admet-276	211	17	developed	develop	VERB
admet-276	211	18	for	for	ADP
admet-276	211	19	adc	adc	PROPN
admet-276	211	20	characterization	characterization	NOUN
admet-276	211	21	provide	provide	VERB
admet-276	211	22	powerful	powerful	ADJ
admet-276	211	23	tools	tool	NOUN
admet-276	211	24	for	for	ADP
admet-276	211	25	understanding	understand	VERB
admet-276	211	26	the	the	DET
admet-276	211	27	fate	fate	NOUN
admet-276	211	28	of	of	ADP
admet-276	211	29	adcs	adcs	NOUN
admet-276	211	30	in	in	ADP
admet-276	211	31	vivo	vivo	NOUN
admet-276	211	32	[	[	X
admet-276	211	33	85	85	NUM
admet-276	211	34	]	]	PUNCT
admet-276	211	35	.	.	PUNCT
admet-276	212	1	3.4	3.4	NUM
admet-276	212	2	matrix	matrix	NOUN
admet-276	212	3	interference	interference	NOUN
admet-276	212	4	another	another	DET
admet-276	212	5	bioanalytical	bioanalytical	ADJ
admet-276	212	6	challenge	challenge	NOUN
admet-276	212	7	is	be	AUX
admet-276	212	8	matrix	matrix	NOUN
admet-276	212	9	interference	interference	NOUN
admet-276	212	10	with	with	ADP
admet-276	212	11	reagents	reagent	NOUN
admet-276	212	12	in	in	ADP
admet-276	212	13	biological	biological	ADJ
admet-276	212	14	samples	sample	NOUN
admet-276	212	15	in	in	ADP
admet-276	212	16	lba	lba	NOUN
admet-276	212	17	when	when	SCONJ
admet-276	212	18	evaluating	evaluate	VERB
admet-276	212	19	pk	pk	NOUN
admet-276	212	20	or	or	CCONJ
admet-276	212	21	ada	ada	PROPN
admet-276	212	22	,	,	PUNCT
admet-276	212	23	e.g.	e.g.	ADV
admet-276	212	24	,	,	PUNCT
admet-276	212	25	circulating	circulate	VERB
admet-276	212	26	drug	drug	NOUN
admet-276	212	27	may	may	AUX
admet-276	212	28	interfere	interfere	VERB
admet-276	212	29	with	with	ADP
admet-276	212	30	the	the	DET
admet-276	212	31	detection	detection	NOUN
admet-276	212	32	of	of	ADP
admet-276	212	33	ada	ada	PROPN
admet-276	212	34	and	and	CCONJ
admet-276	212	35	drug	drug	NOUN
admet-276	212	36	target	target	NOUN
admet-276	212	37	,	,	PUNCT
admet-276	212	38	or	or	CCONJ
admet-276	212	39	ada	ada	PROPN
admet-276	212	40	may	may	AUX
admet-276	212	41	interfere	interfere	VERB
admet-276	212	42	with	with	ADP
admet-276	212	43	quantitation	quantitation	NOUN
admet-276	212	44	of	of	ADP
admet-276	212	45	drug	drug	NOUN
admet-276	212	46	levels	level	NOUN
admet-276	212	47	in	in	ADP
admet-276	212	48	pk	pk	PROPN
admet-276	212	49	/	/	SYM
admet-276	212	50	tk	tk	PROPN
admet-276	212	51	bioanalysis	bioanalysis	NOUN
admet-276	212	52	.	.	PUNCT
admet-276	213	1	in	in	ADP
admet-276	213	2	addition	addition	NOUN
admet-276	213	3	to	to	ADP
admet-276	213	4	the	the	DET
admet-276	213	5	most	most	ADV
admet-276	213	6	commonly	commonly	ADV
admet-276	213	7	used	use	VERB
admet-276	213	8	sample	sample	NOUN
admet-276	213	9	dilution	dilution	NOUN
admet-276	213	10	method	method	NOUN
admet-276	213	11	,	,	PUNCT
admet-276	213	12	the	the	DET
admet-276	213	13	emergent	emergent	ADJ
admet-276	213	14	technologies	technology	NOUN
admet-276	213	15	action	action	NOUN
admet-276	213	16	program	program	NOUN
admet-276	213	17	committee	committee	NOUN
admet-276	213	18	(	(	PUNCT
admet-276	213	19	etapc	etapc	PROPN
admet-276	213	20	)	)	PUNCT
admet-276	213	21	working	work	VERB
admet-276	213	22	group	group	NOUN
admet-276	213	23	has	have	AUX
admet-276	213	24	recently	recently	ADV
admet-276	213	25	discussed	discuss	VERB
admet-276	213	26	several	several	ADJ
admet-276	213	27	emerging	emerge	VERB
admet-276	213	28	technologies	technology	NOUN
admet-276	213	29	such	such	ADJ
admet-276	213	30	as	as	ADP
admet-276	213	31	the	the	DET
admet-276	213	32	singulex	singulex	ADJ
admet-276	213	33	®	®	NOUN
admet-276	213	34	erenna	erenna	NOUN
admet-276	213	35	®	®	NOUN
admet-276	213	36	platform	platform	NOUN
admet-276	213	37	,	,	PUNCT
admet-276	213	38	quanterix	quanterix	PROPN
admet-276	213	39	’s	’s	PART
admet-276	213	40	proprietary	proprietary	ADJ
admet-276	213	41	simoa	simoa	NOUN
admet-276	213	42	™	™	VERB
admet-276	213	43	technology	technology	NOUN
admet-276	213	44	(	(	PUNCT
admet-276	213	45	single	single	ADJ
admet-276	213	46	molecule	molecule	NOUN
admet-276	213	47	array	array	NOUN
admet-276	213	48	)	)	PUNCT
admet-276	213	49	,	,	PUNCT
admet-276	213	50	anp	anp	PROPN
admet-276	213	51	technologies	technologies	PROPN
admet-276	213	52	’	'	PUNCT
admet-276	213	53	npx4000	npx4000	X
admet-276	213	54	nanoparticles	nanoparticle	NOUN
admet-276	213	55	,	,	PUNCT
admet-276	213	56	sqi	sqi	VERB
admet-276	213	57	diagnostic	diagnostic	PROPN
admet-276	213	58	’s	’s	PART
admet-276	213	59	ig	ig	PROPN
admet-276	213	60	plex	plex	ADJ
admet-276	213	61	™	™	PROPN
admet-276	213	62	and	and	CCONJ
admet-276	213	63	genalyte	genalyte	NOUN
admet-276	213	64	’s	’s	PART
admet-276	213	65	maverick	maverick	NOUN
admet-276	213	66	™	™	ADJ
admet-276	213	67	technology	technology	NOUN
admet-276	213	68	,	,	PUNCT
admet-276	213	69	the	the	DET
admet-276	213	70	maverick	maverick	NOUN
admet-276	213	71	detection	detection	NOUN
admet-276	213	72	system	system	NOUN
admet-276	213	73	,	,	PUNCT
admet-276	213	74	to	to	PART
admet-276	213	75	deal	deal	VERB
admet-276	213	76	with	with	ADP
admet-276	213	77	matrix	matrix	NOUN
admet-276	213	78	effect	effect	NOUN
admet-276	213	79	on	on	ADP
admet-276	213	80	possible	possible	ADJ
admet-276	213	81	false	false	ADJ
admet-276	213	82	positive	positive	ADJ
admet-276	213	83	or	or	CCONJ
admet-276	213	84	negative	negative	ADJ
admet-276	213	85	ada	ada	NOUN
admet-276	213	86	detection	detection	NOUN
admet-276	213	87	[	[	X
admet-276	213	88	86	86	NUM
admet-276	213	89	]	]	PUNCT
admet-276	213	90	.	.	PUNCT
admet-276	214	1	moreover	moreover	ADV
admet-276	214	2	,	,	PUNCT
admet-276	214	3	zoghbi	zoghbi	PROPN
admet-276	214	4	et	et	PROPN
admet-276	214	5	al	al	PROPN
admet-276	214	6	.	.	PROPN
admet-276	214	7	have	have	AUX
admet-276	214	8	developed	develop	VERB
admet-276	214	9	a	a	DET
admet-276	214	10	breakthrough	breakthrough	ADJ
admet-276	214	11	novel	novel	NOUN
admet-276	214	12	method	method	NOUN
admet-276	214	13	using	use	VERB
admet-276	214	14	precipitation	precipitation	NOUN
admet-276	214	15	and	and	CCONJ
admet-276	214	16	acid	acid	NOUN
admet-276	214	17	dissociation	dissociation	NOUN
admet-276	214	18	(	(	PUNCT
admet-276	214	19	panda	panda	NOUN
admet-276	214	20	)	)	PUNCT
admet-276	214	21	to	to	PART
admet-276	214	22	overcome	overcome	VERB
admet-276	214	23	drug	drug	NOUN
admet-276	214	24	interference	interference	NOUN
admet-276	214	25	in	in	ADP
admet-276	214	26	the	the	DET
admet-276	214	27	ada	ada	PROPN
admet-276	214	28	assay	assay	PROPN
admet-276	214	29	,	,	PUNCT
admet-276	214	30	showing	show	VERB
admet-276	214	31	significant	significant	ADJ
admet-276	214	32	improvement	improvement	NOUN
admet-276	214	33	over	over	ADP
admet-276	214	34	the	the	DET
admet-276	214	35	current	current	ADJ
admet-276	214	36	approaches	approach	NOUN
admet-276	214	37	in	in	ADP
admet-276	214	38	detecting	detecting	NOUN
admet-276	214	39	of	of	ADP
admet-276	214	40	ada	ada	PROPN
admet-276	214	41	for	for	ADP
admet-276	214	42	two	two	NUM
admet-276	214	43	igg1	igg1	NOUN
admet-276	214	44	and	and	CCONJ
admet-276	214	45	igg4	igg4	NOUN
admet-276	214	46	drugs	drug	NOUN
admet-276	214	47	as	as	ADP
admet-276	214	48	the	the	DET
admet-276	214	49	examples	example	NOUN
admet-276	214	50	[	[	X
admet-276	214	51	87	87	NUM
admet-276	214	52	]	]	PUNCT
admet-276	214	53	.	.	PUNCT
admet-276	215	1	it	it	PRON
admet-276	215	2	was	be	AUX
admet-276	215	3	thus	thus	ADV
admet-276	215	4	claimed	claim	VERB
admet-276	215	5	that	that	SCONJ
admet-276	215	6	the	the	DET
admet-276	215	7	principle	principle	NOUN
admet-276	215	8	of	of	ADP
admet-276	215	9	this	this	DET
admet-276	215	10	novel	novel	NOUN
admet-276	215	11	assay	assay	NOUN
admet-276	215	12	could	could	AUX
admet-276	215	13	be	be	AUX
admet-276	215	14	used	use	VERB
admet-276	215	15	not	not	PART
admet-276	215	16	only	only	ADV
admet-276	215	17	for	for	ADP
admet-276	215	18	ada	ada	PROPN
admet-276	215	19	assays	assay	NOUN
admet-276	215	20	but	but	CCONJ
admet-276	215	21	also	also	ADV
admet-276	215	22	pk	pk	NOUN
admet-276	215	23	and	and	CCONJ
admet-276	215	24	biomarker	biomarker	NOUN
admet-276	215	25	(	(	PUNCT
admet-276	215	26	drug	drug	NOUN
admet-276	215	27	target	target	NOUN
admet-276	215	28	)	)	PUNCT
admet-276	215	29	analysis	analysis	NOUN
admet-276	215	30	in	in	ADP
admet-276	215	31	the	the	DET
admet-276	215	32	presence	presence	NOUN
admet-276	215	33	of	of	ADP
admet-276	215	34	interference	interference	NOUN
admet-276	215	35	factors	factor	NOUN
admet-276	215	36	.	.	PUNCT
admet-276	216	1	4	4	X
admet-276	216	2	.	.	X
admet-276	216	3	regulatory	regulatory	ADJ
admet-276	216	4	considerations	consideration	NOUN
admet-276	216	5	regulatory	regulatory	ADJ
admet-276	216	6	guidance	guidance	NOUN
admet-276	216	7	on	on	ADP
admet-276	216	8	metabolites	metabolite	NOUN
admet-276	216	9	and	and	CCONJ
admet-276	216	10	ddi	ddi	NOUN
admet-276	216	11	as	as	ADV
admet-276	216	12	well	well	ADV
admet-276	216	13	as	as	ADP
admet-276	216	14	bioanalytical	bioanalytical	ADJ
admet-276	216	15	considerations	consideration	NOUN
admet-276	216	16	for	for	ADP
admet-276	216	17	sms	sms	PROPN
admet-276	216	18	is	be	AUX
admet-276	216	19	well	well	ADV
admet-276	216	20	defined	define	VERB
admet-276	216	21	[	[	PUNCT
admet-276	216	22	21	21	NUM
admet-276	216	23	-	-	PUNCT
admet-276	216	24	23,39,59,88	23,39,59,88	NUM
admet-276	216	25	]	]	PUNCT
admet-276	216	26	.	.	PUNCT
admet-276	217	1	in	in	ADP
admet-276	217	2	the	the	DET
admet-276	217	3	recent	recent	ADJ
admet-276	217	4	fda	fda	PROPN
admet-276	217	5	guidance	guidance	NOUN
admet-276	217	6	[	[	X
admet-276	217	7	89	89	NUM
admet-276	217	8	]	]	PUNCT
admet-276	217	9	,	,	PUNCT
admet-276	217	10	bioanalytical	bioanalytical	ADJ
admet-276	217	11	consideration	consideration	NOUN
admet-276	217	12	for	for	ADP
admet-276	217	13	biopharmaceutics	biopharmaceutics	NOUN
admet-276	217	14	has	have	AUX
admet-276	217	15	also	also	ADV
admet-276	217	16	been	be	AUX
admet-276	217	17	included	include	VERB
admet-276	217	18	for	for	ADP
admet-276	217	19	industry	industry	NOUN
admet-276	217	20	bioanalytical	bioanalytical	ADJ
admet-276	217	21	method	method	NOUN
admet-276	217	22	validation	validation	NOUN
admet-276	217	23	.	.	PUNCT
admet-276	218	1	general	general	ADJ
admet-276	218	2	guidelines	guideline	NOUN
admet-276	218	3	on	on	ADP
admet-276	218	4	preclinical	preclinical	ADJ
admet-276	218	5	safety	safety	NOUN
admet-276	218	6	evaluations	evaluation	NOUN
admet-276	218	7	including	include	VERB
admet-276	218	8	immunotoxicity	immunotoxicity	NOUN
admet-276	218	9	of	of	ADP
admet-276	218	10	biotechnology	biotechnology	NOUN
admet-276	218	11	-	-	PUNCT
admet-276	218	12	derived	derive	VERB
admet-276	218	13	pharmaceuticals	pharmaceutical	NOUN
admet-276	218	14	are	be	AUX
admet-276	218	15	available	available	ADJ
admet-276	218	16	[	[	X
admet-276	218	17	34,55,90	34,55,90	NUM
admet-276	218	18	]	]	X
admet-276	218	19	.	.	PUNCT
admet-276	219	1	currently	currently	ADV
admet-276	219	2	,	,	PUNCT
admet-276	219	3	it	it	PRON
admet-276	219	4	seems	seem	VERB
admet-276	219	5	no	no	DET
admet-276	219	6	requirement	requirement	NOUN
admet-276	219	7	or	or	CCONJ
admet-276	219	8	guidance	guidance	NOUN
admet-276	219	9	for	for	ADP
admet-276	219	10	metabolic	metabolic	NOUN
admet-276	219	11	investigation	investigation	NOUN
admet-276	219	12	of	of	ADP
admet-276	219	13	mabs	mab	NOUN
admet-276	219	14	from	from	ADP
admet-276	219	15	regulatory	regulatory	ADJ
admet-276	219	16	agencies	agency	NOUN
admet-276	219	17	probably	probably	ADV
admet-276	219	18	because	because	SCONJ
admet-276	219	19	it	it	PRON
admet-276	219	20	is	be	AUX
admet-276	219	21	generally	generally	ADV
admet-276	219	22	accepted	accept	VERB
admet-276	219	23	that	that	SCONJ
admet-276	219	24	mabs	mab	NOUN
admet-276	219	25	are	be	AUX
admet-276	219	26	unlikely	unlikely	ADJ
admet-276	219	27	to	to	PART
admet-276	219	28	undergo	undergo	VERB
admet-276	219	29	significant	significant	ADJ
admet-276	219	30	biotransformation	biotransformation	NOUN
admet-276	219	31	.	.	PUNCT
admet-276	220	1	the	the	DET
admet-276	220	2	products	product	NOUN
admet-276	220	3	of	of	ADP
admet-276	220	4	lysosomal	lysosomal	ADJ
admet-276	220	5	degradation	degradation	NOUN
admet-276	220	6	of	of	ADP
admet-276	220	7	mabs	mab	NOUN
admet-276	220	8	are	be	AUX
admet-276	220	9	assumed	assume	VERB
admet-276	220	10	to	to	PART
admet-276	220	11	be	be	AUX
admet-276	220	12	small	small	ADJ
admet-276	220	13	peptides	peptide	NOUN
admet-276	220	14	,	,	PUNCT
admet-276	220	15	amino	amino	ADJ
admet-276	220	16	acids	acid	NOUN
admet-276	220	17	and	and	CCONJ
admet-276	220	18	small	small	ADJ
admet-276	220	19	carbohydrates	carbohydrate	NOUN
admet-276	220	20	that	that	PRON
admet-276	220	21	are	be	AUX
admet-276	220	22	readily	readily	ADV
admet-276	220	23	eliminated	eliminate	VERB
admet-276	220	24	by	by	ADP
admet-276	220	25	renal	renal	ADJ
admet-276	220	26	excretion	excretion	NOUN
admet-276	220	27	or	or	CCONJ
admet-276	220	28	return	return	VERB
admet-276	220	29	to	to	ADP
admet-276	220	30	the	the	DET
admet-276	220	31	nutrient	nutrient	NOUN
admet-276	220	32	admet	admet	NOUN
admet-276	220	33	&	&	CCONJ
admet-276	220	34	dmpk	dmpk	PROPN
admet-276	220	35	4(1	4(1	NOUN
admet-276	220	36	)	)	PUNCT
admet-276	220	37	(	(	PUNCT
admet-276	220	38	2016	2016	NUM
admet-276	220	39	)	)	PUNCT
admet-276	220	40	1	1	NUM
admet-276	220	41	-	-	SYM
admet-276	220	42	22	22	NUM
admet-276	220	43	adme	adme	NOUN
admet-276	220	44	testing	testing	NOUN
admet-276	220	45	of	of	ADP
admet-276	220	46	large	large	ADJ
admet-276	220	47	biologics	biologic	NOUN
admet-276	220	48	doi	doi	NOUN
admet-276	220	49	:	:	PUNCT
admet-276	220	50	10.5599	10.5599	NUM
admet-276	220	51	/	/	SYM
admet-276	220	52	admet.4.1.276	admet.4.1.276	NUM
admet-276	220	53	13	13	NUM
admet-276	220	54	pool	pool	NOUN
admet-276	220	55	without	without	ADP
admet-276	220	56	biological	biological	ADJ
admet-276	220	57	effects	effect	NOUN
admet-276	220	58	.	.	PUNCT
admet-276	221	1	however	however	ADV
admet-276	221	2	,	,	PUNCT
admet-276	221	3	this	this	DET
admet-276	221	4	assumption	assumption	NOUN
admet-276	221	5	may	may	AUX
admet-276	221	6	not	not	PART
admet-276	221	7	be	be	AUX
admet-276	221	8	true	true	ADJ
admet-276	221	9	for	for	ADP
admet-276	221	10	mab	mab	NOUN
admet-276	221	11	derivatives	derivative	NOUN
admet-276	221	12	such	such	ADJ
admet-276	221	13	as	as	ADP
admet-276	221	14	fusion	fusion	NOUN
admet-276	221	15	proteins	protein	NOUN
admet-276	221	16	and	and	CCONJ
admet-276	221	17	antibody	antibody	NOUN
admet-276	221	18	–	–	PUNCT
admet-276	221	19	drug	drug	NOUN
admet-276	221	20	conjugates	conjugate	NOUN
admet-276	221	21	(	(	PUNCT
admet-276	221	22	adcs	adcs	ADJ
admet-276	221	23	)	)	PUNCT
admet-276	222	1	[	[	X
admet-276	222	2	2	2	NUM
admet-276	222	3	]	]	PUNCT
admet-276	222	4	.	.	PUNCT
admet-276	223	1	indeed	indeed	ADV
admet-276	223	2	,	,	PUNCT
admet-276	223	3	therapeutic	therapeutic	ADJ
admet-276	223	4	protein	protein	NOUN
admet-276	223	5	-	-	PUNCT
admet-276	223	6	drug	drug	NOUN
admet-276	223	7	interactions	interaction	NOUN
admet-276	223	8	and	and	CCONJ
admet-276	223	9	implications	implication	NOUN
admet-276	223	10	for	for	ADP
admet-276	223	11	drug	drug	NOUN
admet-276	223	12	development	development	NOUN
admet-276	223	13	have	have	AUX
admet-276	223	14	been	be	AUX
admet-276	223	15	observed	observe	VERB
admet-276	223	16	in	in	ADP
admet-276	223	17	clinic	clinic	NOUN
admet-276	223	18	[	[	X
admet-276	223	19	25,91	25,91	NOUN
admet-276	223	20	]	]	X
admet-276	223	21	.	.	PUNCT
admet-276	224	1	as	as	ADP
admet-276	224	2	a	a	DET
admet-276	224	3	consequence	consequence	NOUN
admet-276	224	4	,	,	PUNCT
admet-276	224	5	ddi	ddi	PROPN
admet-276	224	6	studies	study	NOUN
admet-276	224	7	on	on	ADP
admet-276	224	8	biologics	biologic	NOUN
admet-276	224	9	have	have	AUX
admet-276	224	10	been	be	AUX
admet-276	224	11	outlined	outline	VERB
admet-276	224	12	in	in	ADP
admet-276	224	13	the	the	DET
admet-276	224	14	draft	draft	NOUN
admet-276	224	15	guidance	guidance	NOUN
admet-276	224	16	[	[	X
admet-276	224	17	23	23	NUM
admet-276	224	18	]	]	PUNCT
admet-276	224	19	,	,	PUNCT
admet-276	224	20	which	which	PRON
admet-276	224	21	becomes	become	VERB
admet-276	224	22	a	a	DET
admet-276	224	23	major	major	ADJ
admet-276	224	24	concern	concern	NOUN
admet-276	224	25	for	for	ADP
admet-276	224	26	safety	safety	NOUN
admet-276	224	27	evaluations	evaluation	NOUN
admet-276	224	28	of	of	ADP
admet-276	224	29	biologic	biologic	NOUN
admet-276	224	30	for	for	ADP
admet-276	224	31	investigational	investigational	ADJ
admet-276	224	32	new	new	ADJ
admet-276	224	33	drug	drug	NOUN
admet-276	224	34	(	(	PUNCT
admet-276	224	35	ind	ind	NOUN
admet-276	224	36	)	)	PUNCT
admet-276	224	37	filing	filing	NOUN
admet-276	224	38	.	.	PUNCT
admet-276	225	1	unlike	unlike	ADP
admet-276	225	2	the	the	DET
admet-276	225	3	mabs	mab	NOUN
admet-276	225	4	,	,	PUNCT
admet-276	225	5	an	an	DET
admet-276	225	6	additional	additional	ADJ
admet-276	225	7	consideration	consideration	NOUN
admet-276	225	8	for	for	ADP
admet-276	225	9	adcs	adcs	ADJ
admet-276	225	10	is	be	AUX
admet-276	225	11	the	the	DET
admet-276	225	12	adme	adme	NOUN
admet-276	225	13	and	and	CCONJ
admet-276	225	14	safety	safety	NOUN
admet-276	225	15	evaluations	evaluation	NOUN
admet-276	225	16	of	of	ADP
admet-276	225	17	novel	novel	ADJ
admet-276	225	18	cytotoxic	cytotoxic	ADJ
admet-276	225	19	compounds	compound	NOUN
admet-276	225	20	since	since	SCONJ
admet-276	225	21	the	the	DET
admet-276	225	22	cytotoxic	cytotoxic	ADJ
admet-276	225	23	drug	drug	NOUN
admet-276	225	24	or	or	CCONJ
admet-276	225	25	its	its	PRON
admet-276	225	26	derivatives	derivative	NOUN
admet-276	225	27	can	can	AUX
admet-276	225	28	be	be	AUX
admet-276	225	29	regarded	regard	VERB
admet-276	225	30	as	as	ADP
admet-276	225	31	the	the	DET
admet-276	225	32	api	api	NOUN
admet-276	225	33	rather	rather	ADV
admet-276	225	34	than	than	ADP
admet-276	225	35	intermediate	intermediate	ADJ
admet-276	225	36	during	during	ADP
admet-276	225	37	adc	adc	PROPN
admet-276	225	38	synthesis	synthesis	NOUN
admet-276	225	39	from	from	ADP
admet-276	225	40	regulatory	regulatory	ADJ
admet-276	225	41	compliance	compliance	NOUN
admet-276	225	42	and	and	CCONJ
admet-276	225	43	cmc	cmc	NOUN
admet-276	225	44	perspectives	perspective	NOUN
admet-276	225	45	.	.	PUNCT
admet-276	226	1	for	for	ADP
admet-276	226	2	instance	instance	NOUN
admet-276	226	3	,	,	PUNCT
admet-276	226	4	the	the	DET
admet-276	226	5	unreacted	unreacted	ADJ
admet-276	226	6	cytotoxic	cytotoxic	ADJ
admet-276	226	7	drug	drug	NOUN
admet-276	226	8	or	or	CCONJ
admet-276	226	9	linker	linker	NOUN
admet-276	226	10	might	might	AUX
admet-276	226	11	remain	remain	VERB
admet-276	226	12	in	in	ADP
admet-276	226	13	the	the	DET
admet-276	226	14	final	final	ADJ
admet-276	226	15	adc	adc	PROPN
admet-276	226	16	drug	drug	NOUN
admet-276	226	17	product	product	NOUN
admet-276	226	18	.	.	PUNCT
admet-276	227	1	if	if	SCONJ
admet-276	227	2	the	the	DET
admet-276	227	3	concentrations	concentration	NOUN
admet-276	227	4	of	of	ADP
admet-276	227	5	these	these	DET
admet-276	227	6	impurities	impurity	NOUN
admet-276	227	7	are	be	AUX
admet-276	227	8	minimal	minimal	ADJ
admet-276	227	9	(	(	PUNCT
admet-276	227	10	e.g.	e.g.	ADV
admet-276	227	11	,	,	PUNCT
admet-276	227	12	<	<	X
admet-276	227	13	0.2	0.2	NUM
admet-276	227	14	%	%	NOUN
admet-276	227	15	)	)	PUNCT
admet-276	227	16	,	,	PUNCT
admet-276	227	17	then	then	ADV
admet-276	227	18	independent	independent	ADJ
admet-276	227	19	testing	testing	NOUN
admet-276	227	20	of	of	ADP
admet-276	227	21	this	this	DET
admet-276	227	22	component	component	NOUN
admet-276	227	23	may	may	AUX
admet-276	227	24	not	not	PART
admet-276	227	25	be	be	AUX
admet-276	227	26	necessary	necessary	ADJ
admet-276	227	27	[	[	X
admet-276	227	28	92,93	92,93	X
admet-276	227	29	]	]	X
admet-276	227	30	,	,	PUNCT
admet-276	227	31	and	and	CCONJ
admet-276	227	32	vice	vice	ADV
admet-276	227	33	versa	versa	ADV
admet-276	227	34	.	.	PUNCT
admet-276	228	1	according	accord	VERB
admet-276	228	2	to	to	ADP
admet-276	228	3	recent	recent	ADJ
admet-276	228	4	suggestions	suggestion	NOUN
admet-276	228	5	by	by	ADP
admet-276	228	6	cder	cder	NOUN
admet-276	228	7	and	and	CCONJ
admet-276	228	8	aaps	aap	NOUN
admet-276	228	9	experts	expert	NOUN
admet-276	228	10	[	[	X
admet-276	228	11	94	94	NUM
admet-276	228	12	]	]	PUNCT
admet-276	228	13	,	,	PUNCT
admet-276	228	14	free	free	ADJ
admet-276	228	15	drug	drug	NOUN
admet-276	228	16	related	relate	VERB
admet-276	228	17	impurities	impurity	NOUN
admet-276	228	18	in	in	ADP
admet-276	228	19	clinical	clinical	ADJ
admet-276	228	20	lot	lot	NOUN
admet-276	228	21	should	should	AUX
admet-276	228	22	be	be	AUX
admet-276	228	23	qualified	qualified	ADJ
admet-276	228	24	relative	relative	ADJ
admet-276	228	25	to	to	ADP
admet-276	228	26	data	datum	NOUN
admet-276	228	27	from	from	ADP
admet-276	228	28	toxicology	toxicology	NOUN
admet-276	228	29	studies	study	NOUN
admet-276	228	30	.	.	PUNCT
admet-276	229	1	comparable	comparable	ADJ
admet-276	229	2	drug	drug	NOUN
admet-276	229	3	/	/	SYM
admet-276	229	4	antibody	antibody	NOUN
admet-276	229	5	ratios	ratio	NOUN
admet-276	229	6	should	should	AUX
admet-276	229	7	be	be	AUX
admet-276	229	8	maintained	maintain	VERB
admet-276	229	9	between	between	ADP
admet-276	229	10	the	the	DET
admet-276	229	11	toxicology	toxicology	NOUN
admet-276	229	12	lot	lot	NOUN
admet-276	229	13	and	and	CCONJ
admet-276	229	14	the	the	DET
admet-276	229	15	clinical	clinical	ADJ
admet-276	229	16	lot	lot	NOUN
admet-276	229	17	.	.	PUNCT
admet-276	230	1	characterization	characterization	NOUN
admet-276	230	2	of	of	ADP
admet-276	230	3	the	the	DET
admet-276	230	4	impurity	impurity	NOUN
admet-276	230	5	profile	profile	NOUN
admet-276	230	6	of	of	ADP
admet-276	230	7	drug	drug	NOUN
admet-276	230	8	/	/	SYM
admet-276	230	9	linker	linker	NOUN
admet-276	230	10	intermediates	intermediate	NOUN
admet-276	230	11	including	include	VERB
admet-276	230	12	structure	structure	NOUN
admet-276	230	13	determination	determination	NOUN
admet-276	230	14	of	of	ADP
admet-276	230	15	individual	individual	ADJ
admet-276	230	16	impurities	impurity	NOUN
admet-276	230	17	(	(	PUNCT
admet-276	230	18	even	even	ADV
admet-276	230	19	likely	likely	ADJ
admet-276	230	20	intermediates	intermediate	NOUN
admet-276	230	21	)	)	PUNCT
admet-276	230	22	at	at	ADP
admet-276	230	23	levels	level	NOUN
admet-276	230	24	>	>	PUNCT
admet-276	230	25	0.1	0.1	NUM
admet-276	230	26	%	%	NOUN
admet-276	230	27	is	be	AUX
admet-276	230	28	recommended	recommend	VERB
admet-276	230	29	prior	prior	ADV
admet-276	230	30	to	to	ADP
admet-276	230	31	pivotal	pivotal	ADJ
admet-276	230	32	clinical	clinical	ADJ
admet-276	230	33	trials	trial	NOUN
admet-276	230	34	.	.	PUNCT
admet-276	231	1	again	again	ADV
admet-276	231	2	,	,	PUNCT
admet-276	231	3	given	give	VERB
admet-276	231	4	the	the	DET
admet-276	231	5	examples	example	NOUN
admet-276	231	6	of	of	ADP
admet-276	231	7	two	two	NUM
admet-276	231	8	approved	approve	VERB
admet-276	231	9	adc	adc	PROPN
admet-276	231	10	drugs	drug	NOUN
admet-276	231	11	,	,	PUNCT
admet-276	231	12	e.g.	e.g.	ADV
admet-276	231	13	adcetris	adcetris	NOUN
admet-276	231	14	and	and	CCONJ
admet-276	231	15	kadcyla	kadcyla	NOUN
admet-276	231	16	,	,	PUNCT
admet-276	231	17	adme	adme	NOUN
admet-276	231	18	testing	testing	NOUN
admet-276	231	19	and	and	CCONJ
admet-276	231	20	non	non	ADJ
admet-276	231	21	-	-	ADJ
admet-276	231	22	clinical	clinical	ADJ
admet-276	231	23	safety	safety	NOUN
admet-276	231	24	assessments	assessment	NOUN
admet-276	231	25	of	of	ADP
admet-276	231	26	the	the	DET
admet-276	231	27	adc	adc	PROPN
admet-276	231	28	as	as	ADV
admet-276	231	29	well	well	ADV
admet-276	231	30	as	as	ADP
admet-276	231	31	the	the	DET
admet-276	231	32	cytotoxic	cytotoxic	ADJ
admet-276	231	33	drug	drug	NOUN
admet-276	231	34	according	accord	VERB
admet-276	231	35	to	to	ADP
admet-276	231	36	the	the	DET
admet-276	231	37	cmc	cmc	NOUN
admet-276	231	38	criteria	criterion	NOUN
admet-276	231	39	are	be	AUX
admet-276	231	40	essential	essential	ADJ
admet-276	231	41	for	for	ADP
admet-276	231	42	ind	ind	NOUN
admet-276	231	43	filing	filing	NOUN
admet-276	231	44	.	.	PUNCT
admet-276	232	1	regardless	regardless	ADV
admet-276	232	2	of	of	ADP
admet-276	232	3	the	the	DET
admet-276	232	4	regulatory	regulatory	ADJ
admet-276	232	5	pathway	pathway	NOUN
admet-276	232	6	,	,	PUNCT
admet-276	232	7	characterization	characterization	NOUN
admet-276	232	8	,	,	PUNCT
admet-276	232	9	comparability	comparability	NOUN
admet-276	232	10	,	,	PUNCT
admet-276	232	11	release	release	NOUN
admet-276	232	12	and	and	CCONJ
admet-276	232	13	stability	stability	NOUN
admet-276	232	14	assays	assay	NOUN
admet-276	232	15	need	need	VERB
admet-276	232	16	to	to	PART
admet-276	232	17	be	be	AUX
admet-276	232	18	appropriate	appropriate	ADJ
admet-276	232	19	for	for	SCONJ
admet-276	232	20	the	the	DET
admet-276	232	21	molecule	molecule	NOUN
admet-276	232	22	to	to	PART
admet-276	232	23	be	be	AUX
admet-276	232	24	analyzed	analyze	VERB
admet-276	232	25	.	.	PUNCT
admet-276	233	1	before	before	SCONJ
admet-276	233	2	more	more	ADV
admet-276	233	3	detailed	detailed	ADJ
admet-276	233	4	guidelines	guideline	NOUN
admet-276	233	5	on	on	ADP
admet-276	233	6	lm	lm	INTJ
admet-276	233	7	bioanalysis	bioanalysis	NOUN
admet-276	233	8	are	be	AUX
admet-276	233	9	available	available	ADJ
admet-276	233	10	[	[	X
admet-276	233	11	89	89	NUM
admet-276	233	12	]	]	X
admet-276	233	13	,	,	PUNCT
admet-276	233	14	an	an	DET
admet-276	233	15	alternative	alternative	ADJ
admet-276	233	16	lc	lc	NOUN
admet-276	233	17	-	-	PUNCT
admet-276	233	18	ms	ms	PROPN
admet-276	233	19	/	/	SYM
admet-276	233	20	ms	ms	NOUN
admet-276	233	21	technique	technique	NOUN
admet-276	233	22	is	be	AUX
admet-276	233	23	anticipated	anticipate	VERB
admet-276	233	24	to	to	PART
admet-276	233	25	serve	serve	VERB
admet-276	233	26	as	as	ADP
admet-276	233	27	a	a	DET
admet-276	233	28	complementary	complementary	ADJ
admet-276	233	29	technique	technique	NOUN
admet-276	233	30	to	to	PART
admet-276	233	31	quantify	quantify	VERB
admet-276	233	32	the	the	DET
admet-276	233	33	antibody	antibody	NOUN
admet-276	233	34	or	or	CCONJ
admet-276	233	35	adc	adc	PROPN
admet-276	233	36	in	in	ADP
admet-276	233	37	plasma	plasma	NOUN
admet-276	233	38	for	for	ADP
admet-276	233	39	more	more	ADJ
admet-276	233	40	applications	application	NOUN
admet-276	233	41	of	of	ADP
admet-276	233	42	pk	pk	NOUN
admet-276	233	43	determinations	determination	NOUN
admet-276	233	44	as	as	ADV
admet-276	233	45	well	well	ADV
admet-276	233	46	as	as	ADP
admet-276	233	47	the	the	DET
admet-276	233	48	quality	quality	NOUN
admet-276	233	49	control	control	NOUN
admet-276	233	50	of	of	ADP
admet-276	233	51	lms	lm	NOUN
admet-276	233	52	.	.	PUNCT
admet-276	234	1	given	give	VERB
admet-276	234	2	the	the	DET
admet-276	234	3	fact	fact	NOUN
admet-276	234	4	of	of	ADP
admet-276	234	5	increasingly	increasingly	ADV
admet-276	234	6	growing	grow	VERB
admet-276	234	7	interest	interest	NOUN
admet-276	234	8	in	in	ADP
admet-276	234	9	biotherapeutics	biotherapeutic	NOUN
admet-276	234	10	,	,	PUNCT
admet-276	234	11	development	development	NOUN
admet-276	234	12	and	and	CCONJ
admet-276	234	13	validation	validation	NOUN
admet-276	234	14	of	of	ADP
admet-276	234	15	cutting	cut	VERB
admet-276	234	16	-	-	PUNCT
admet-276	234	17	edge	edge	NOUN
admet-276	234	18	bioanalytical	bioanalytical	ADJ
admet-276	234	19	methods	method	NOUN
admet-276	234	20	are	be	AUX
admet-276	234	21	highly	highly	ADV
admet-276	234	22	desirable	desirable	ADJ
admet-276	234	23	for	for	ADP
admet-276	234	24	novel	novel	ADJ
admet-276	234	25	mabs	mab	NOUN
admet-276	234	26	and	and	CCONJ
admet-276	234	27	next	next	ADJ
admet-276	234	28	generation	generation	NOUN
admet-276	234	29	of	of	ADP
admet-276	234	30	adcs	adcs	ADJ
admet-276	234	31	.	.	PUNCT
admet-276	235	1	strong	strong	ADJ
admet-276	235	2	regulatory	regulatory	ADJ
admet-276	235	3	guidance	guidance	NOUN
admet-276	235	4	and	and	CCONJ
admet-276	235	5	standard	standard	ADJ
admet-276	235	6	industry	industry	NOUN
admet-276	235	7	best	good	ADJ
admet-276	235	8	practices	practice	NOUN
admet-276	235	9	for	for	ADP
admet-276	235	10	admet	admet	NOUN
admet-276	235	11	testing	testing	NOUN
admet-276	235	12	of	of	ADP
admet-276	235	13	lms	lm	NOUN
admet-276	235	14	and	and	CCONJ
admet-276	235	15	related	related	ADJ
admet-276	235	16	bioanalytical	bioanalytical	ADJ
admet-276	235	17	considerations	consideration	NOUN
admet-276	235	18	are	be	AUX
admet-276	235	19	expected	expect	VERB
admet-276	235	20	to	to	PART
admet-276	235	21	assess	assess	VERB
admet-276	235	22	and	and	CCONJ
admet-276	235	23	manage	manage	VERB
admet-276	235	24	the	the	DET
admet-276	235	25	potential	potential	ADJ
admet-276	235	26	risk	risk	NOUN
admet-276	235	27	of	of	ADP
admet-276	235	28	biotherapeutics	biotherapeutic	NOUN
admet-276	235	29	.	.	PUNCT
admet-276	236	1	5	5	X
admet-276	236	2	.	.	X
admet-276	236	3	analysis	analysis	NOUN
admet-276	236	4	and	and	CCONJ
admet-276	236	5	interpretation	interpretation	NOUN
admet-276	236	6	of	of	ADP
admet-276	236	7	preclinical	preclinical	ADJ
admet-276	236	8	animal	animal	NOUN
admet-276	236	9	pk	pk	NOUN
admet-276	236	10	of	of	ADP
admet-276	236	11	adcs	adcs	PROPN
admet-276	236	12	and	and	CCONJ
admet-276	236	13	human	human	ADJ
admet-276	236	14	pk	pk	NOUN
admet-276	236	15	prediction	prediction	NOUN
admet-276	236	16	one	one	NUM
admet-276	236	17	ultimate	ultimate	ADJ
admet-276	236	18	purpose	purpose	NOUN
admet-276	236	19	of	of	ADP
admet-276	236	20	admet	admet	PROPN
admet-276	236	21	testing	testing	NOUN
admet-276	236	22	is	be	AUX
admet-276	236	23	to	to	PART
admet-276	236	24	understand	understand	VERB
admet-276	236	25	the	the	DET
admet-276	236	26	metabolism	metabolism	NOUN
admet-276	236	27	pathway	pathway	NOUN
admet-276	236	28	of	of	ADP
admet-276	236	29	target	target	NOUN
admet-276	236	30	molecule	molecule	NOUN
admet-276	236	31	in	in	ADP
admet-276	236	32	various	various	ADJ
admet-276	236	33	in	in	ADP
admet-276	236	34	vitro	vitro	X
admet-276	236	35	and	and	CCONJ
admet-276	236	36	in	in	ADP
admet-276	236	37	vivo	vivo	ADJ
admet-276	236	38	species	specie	NOUN
admet-276	236	39	enable	enable	ADJ
admet-276	236	40	to	to	PART
admet-276	236	41	better	well	ADV
admet-276	236	42	predict	predict	VERB
admet-276	236	43	human	human	ADJ
admet-276	236	44	pk	pk	PROPN
admet-276	236	45	.	.	PROPN
admet-276	236	46	in	in	ADP
admet-276	236	47	general	general	ADJ
admet-276	236	48	,	,	PUNCT
admet-276	236	49	the	the	DET
admet-276	236	50	human	human	ADJ
admet-276	236	51	clearance	clearance	NOUN
admet-276	236	52	of	of	ADP
admet-276	236	53	sms	sms	PROPN
admet-276	236	54	is	be	AUX
admet-276	236	55	more	more	ADV
admet-276	236	56	predictable	predictable	ADJ
admet-276	236	57	combining	combine	VERB
admet-276	236	58	in	in	ADP
admet-276	236	59	vitro	vitro	NOUN
admet-276	236	60	and	and	CCONJ
admet-276	236	61	in	in	ADP
admet-276	236	62	vivo	vivo	NOUN
admet-276	236	63	animal	animal	NOUN
admet-276	236	64	data	datum	NOUN
admet-276	236	65	by	by	ADP
admet-276	236	66	means	mean	NOUN
admet-276	236	67	of	of	ADP
admet-276	236	68	well	well	ADV
admet-276	236	69	-	-	PUNCT
admet-276	236	70	stirred	stir	VERB
admet-276	236	71	model	model	NOUN
admet-276	236	72	and	and	CCONJ
admet-276	236	73	commonly	commonly	ADV
admet-276	236	74	used	use	VERB
admet-276	236	75	allometric	allometric	ADJ
admet-276	236	76	scaling	scale	VERB
admet-276	236	77	etc	etc	X
admet-276	237	1	[	[	X
admet-276	237	2	95	95	NUM
admet-276	237	3	-	-	SYM
admet-276	237	4	99	99	NUM
admet-276	237	5	]	]	PUNCT
admet-276	237	6	.	.	PUNCT
admet-276	238	1	the	the	DET
admet-276	238	2	examples	example	NOUN
admet-276	238	3	applying	apply	VERB
admet-276	238	4	allometric	allometric	ADJ
admet-276	238	5	scaling	scaling	NOUN
admet-276	238	6	have	have	AUX
admet-276	238	7	been	be	AUX
admet-276	238	8	reviewed	review	VERB
admet-276	238	9	for	for	ADP
admet-276	238	10	predictions	prediction	NOUN
admet-276	238	11	of	of	ADP
admet-276	238	12	clearance	clearance	NOUN
admet-276	238	13	and	and	CCONJ
admet-276	238	14	volume	volume	NOUN
admet-276	238	15	distribution	distribution	NOUN
admet-276	238	16	of	of	ADP
admet-276	238	17	therapeutic	therapeutic	ADJ
admet-276	238	18	proteins	protein	NOUN
admet-276	238	19	recently	recently	ADV
admet-276	238	20	[	[	X
admet-276	238	21	37	37	NUM
admet-276	238	22	]	]	PUNCT
admet-276	238	23	.	.	PUNCT
admet-276	239	1	however	however	ADV
admet-276	239	2	,	,	PUNCT
admet-276	239	3	it	it	PRON
admet-276	239	4	was	be	AUX
admet-276	239	5	argued	argue	VERB
admet-276	239	6	recently	recently	ADV
admet-276	239	7	that	that	SCONJ
admet-276	239	8	the	the	DET
admet-276	239	9	utility	utility	NOUN
admet-276	239	10	of	of	ADP
admet-276	239	11	allometric	allometric	ADJ
admet-276	239	12	scaling	scaling	NOUN
admet-276	239	13	and	and	CCONJ
admet-276	239	14	body	body	NOUN
admet-276	239	15	surface	surface	NOUN
admet-276	239	16	area	area	NOUN
admet-276	239	17	(	(	PUNCT
admet-276	239	18	bsa	bsa	PROPN
admet-276	239	19	)	)	PUNCT
admet-276	239	20	to	to	PART
admet-276	239	21	translate	translate	VERB
admet-276	239	22	dosage	dosage	NOUN
admet-276	239	23	from	from	ADP
admet-276	239	24	animal	animal	NOUN
admet-276	239	25	models	model	NOUN
admet-276	239	26	to	to	ADP
admet-276	239	27	human	human	ADJ
admet-276	239	28	clinical	clinical	ADJ
admet-276	239	29	trials	trial	NOUN
admet-276	239	30	are	be	AUX
admet-276	239	31	inappropriate	inappropriate	ADJ
admet-276	239	32	for	for	ADP
admet-276	239	33	human	human	ADJ
admet-276	239	34	pk	pk	NOUN
admet-276	239	35	prediction	prediction	NOUN
admet-276	239	36	due	due	ADP
admet-276	239	37	to	to	ADP
admet-276	239	38	interspecies	interspecie	NOUN
admet-276	239	39	difference	difference	NOUN
admet-276	239	40	in	in	ADP
admet-276	239	41	drug	drug	NOUN
admet-276	239	42	metabolism	metabolism	NOUN
admet-276	239	43	clearance	clearance	NOUN
admet-276	239	44	and	and	CCONJ
admet-276	239	45	absorption	absorption	NOUN
admet-276	240	1	[	[	X
admet-276	240	2	100	100	NUM
admet-276	240	3	]	]	PUNCT
admet-276	240	4	.	.	PUNCT
admet-276	241	1	for	for	ADP
admet-276	241	2	mabs	mab	NOUN
admet-276	241	3	exhibiting	exhibit	VERB
admet-276	241	4	a	a	DET
admet-276	241	5	linear	linear	ADJ
admet-276	241	6	pk	pk	NOUN
admet-276	241	7	without	without	ADP
admet-276	241	8	the	the	DET
admet-276	241	9	tmdd	tmdd	ADJ
admet-276	241	10	,	,	PUNCT
admet-276	241	11	allometric	allometric	ADJ
admet-276	241	12	scaling	scale	VERB
admet-276	241	13	approach	approach	NOUN
admet-276	241	14	applying	apply	VERB
admet-276	241	15	different	different	ADJ
admet-276	241	16	scaling	scale	VERB
admet-276	241	17	exponents	exponent	NOUN
admet-276	241	18	is	be	AUX
admet-276	241	19	applicable	applicable	ADJ
admet-276	241	20	for	for	ADP
admet-276	241	21	clearance	clearance	NOUN
admet-276	241	22	and	and	CCONJ
admet-276	241	23	volume	volume	NOUN
admet-276	241	24	distribution	distribution	NOUN
admet-276	241	25	predictions	prediction	NOUN
admet-276	241	26	[	[	X
admet-276	241	27	101	101	NUM
admet-276	241	28	]	]	PUNCT
admet-276	241	29	.	.	PUNCT
admet-276	242	1	alternatively	alternatively	ADV
admet-276	242	2	,	,	PUNCT
admet-276	242	3	pbpk	pbpk	NOUN
admet-276	242	4	modeling	modeling	NOUN
admet-276	242	5	is	be	AUX
admet-276	242	6	considered	consider	VERB
admet-276	242	7	as	as	ADP
admet-276	242	8	more	more	ADV
admet-276	242	9	accurate	accurate	ADJ
admet-276	242	10	human	human	ADJ
admet-276	242	11	pk	pk	NOUN
admet-276	242	12	predictions	prediction	NOUN
admet-276	242	13	for	for	ADP
admet-276	242	14	large	large	ADJ
admet-276	242	15	molecules	molecule	NOUN
admet-276	242	16	with	with	ADP
admet-276	242	17	the	the	DET
admet-276	242	18	linear	linear	ADJ
admet-276	242	19	pk	pk	NOUN
admet-276	243	1	[	[	X
admet-276	243	2	102	102	NUM
admet-276	243	3	]	]	PUNCT
admet-276	243	4	,	,	PUNCT
admet-276	243	5	but	but	CCONJ
admet-276	243	6	it	it	PRON
admet-276	243	7	requires	require	VERB
admet-276	243	8	a	a	DET
admet-276	243	9	number	number	NOUN
admet-276	243	10	of	of	ADP
admet-276	243	11	input	input	NOUN
admet-276	243	12	parameters	parameter	NOUN
admet-276	243	13	to	to	PART
admet-276	243	14	enable	enable	VERB
admet-276	243	15	accurate	accurate	ADJ
admet-276	243	16	human	human	ADJ
admet-276	243	17	pk	pk	NOUN
admet-276	243	18	predictions	prediction	NOUN
admet-276	243	19	,	,	PUNCT
admet-276	243	20	which	which	PRON
admet-276	243	21	limits	limit	VERB
admet-276	243	22	its	its	PRON
admet-276	243	23	applicability	applicability	NOUN
admet-276	243	24	in	in	ADP
admet-276	243	25	drug	drug	NOUN
admet-276	243	26	development	development	NOUN
admet-276	243	27	.	.	PUNCT
admet-276	244	1	a	a	DET
admet-276	244	2	recent	recent	ADJ
admet-276	244	3	survey	survey	NOUN
admet-276	244	4	shows	show	VERB
admet-276	244	5	that	that	SCONJ
admet-276	244	6	minimal	minimal	ADJ
admet-276	244	7	pbpk	pbpk	NOUN
admet-276	244	8	(	(	PUNCT
admet-276	244	9	mpbpk	mpbpk	PROPN
admet-276	244	10	)	)	PUNCT
admet-276	244	11	model	model	NOUN
admet-276	244	12	offers	offer	VERB
admet-276	244	13	a	a	DET
admet-276	244	14	more	more	ADV
admet-276	244	15	mechanistic	mechanistic	ADJ
admet-276	244	16	approach	approach	NOUN
admet-276	244	17	using	use	VERB
admet-276	244	18	the	the	DET
admet-276	244	19	major	major	ADJ
admet-276	244	20	structural	structural	ADJ
admet-276	244	21	features	feature	NOUN
admet-276	244	22	of	of	ADP
admet-276	244	23	full	full	ADJ
admet-276	244	24	pbpk	pbpk	ADJ
admet-276	244	25	models	model	NOUN
admet-276	244	26	for	for	ADP
admet-276	244	27	mabs	mab	NOUN
admet-276	244	28	in	in	ADP
admet-276	244	29	specifically	specifically	ADV
admet-276	244	30	analyzing	analyze	VERB
admet-276	244	31	mab	mab	PROPN
admet-276	244	32	pk	pk	PROPN
admet-276	244	33	than	than	SCONJ
admet-276	244	34	found	find	VERB
admet-276	244	35	in	in	ADP
admet-276	244	36	compartment	compartment	NOUN
admet-276	244	37	models	model	NOUN
admet-276	244	38	and	and	CCONJ
admet-276	244	39	provides	provide	VERB
admet-276	244	40	an	an	DET
admet-276	244	41	intermediary	intermediary	ADJ
admet-276	244	42	method	method	NOUN
admet-276	244	43	if	if	SCONJ
admet-276	244	44	a	a	DET
admet-276	244	45	full	full	ADJ
admet-276	244	46	pbpk	pbpk	ADJ
admet-276	244	47	model	model	NOUN
admet-276	244	48	is	be	AUX
admet-276	244	49	not	not	PART
admet-276	244	50	available	available	ADJ
admet-276	244	51	[	[	X
admet-276	244	52	103	103	NUM
admet-276	244	53	]	]	PUNCT
admet-276	244	54	.	.	PUNCT
admet-276	245	1	comparative	comparative	ADJ
admet-276	245	2	evaluations	evaluation	NOUN
admet-276	245	3	of	of	ADP
admet-276	245	4	prediction	prediction	NOUN
admet-276	245	5	approaches	approach	NOUN
admet-276	245	6	for	for	ADP
admet-276	245	7	projecting	project	VERB
admet-276	245	8	human	human	ADJ
admet-276	245	9	pk	pk	PROPN
admet-276	245	10	of	of	ADP
admet-276	245	11	mabs	mab	NOUN
admet-276	245	12	in	in	ADP
admet-276	245	13	early	early	ADJ
admet-276	245	14	hong	hong	PROPN
admet-276	245	15	wan	wan	PROPN
admet-276	245	16	admet	admet	PROPN
admet-276	245	17	&	&	CCONJ
admet-276	245	18	dmpk	dmpk	PROPN
admet-276	245	19	4(1	4(1	NOUN
admet-276	245	20	)	)	PUNCT
admet-276	245	21	(	(	PUNCT
admet-276	245	22	2016	2016	NUM
admet-276	245	23	)	)	PUNCT
admet-276	245	24	1	1	NUM
admet-276	245	25	-	-	SYM
admet-276	245	26	22	22	NUM
admet-276	245	27	14	14	NUM
admet-276	245	28	drug	drug	NOUN
admet-276	245	29	development	development	NOUN
admet-276	245	30	prior	prior	ADV
admet-276	245	31	to	to	ADP
admet-276	245	32	the	the	DET
admet-276	245	33	first	first	ADJ
admet-276	245	34	-	-	PUNCT
admet-276	245	35	in	in	ADP
admet-276	245	36	-	-	PUNCT
admet-276	245	37	human	human	ADJ
admet-276	245	38	(	(	PUNCT
admet-276	245	39	fih	fih	NOUN
admet-276	245	40	)	)	PUNCT
admet-276	245	41	have	have	AUX
admet-276	245	42	been	be	AUX
admet-276	245	43	reviewed	review	VERB
admet-276	245	44	and	and	CCONJ
admet-276	245	45	decision	decision	NOUN
admet-276	245	46	tree	tree	NOUN
admet-276	245	47	in	in	ADP
admet-276	245	48	support	support	NOUN
admet-276	245	49	of	of	ADP
admet-276	245	50	mab	mab	PROPN
admet-276	245	51	human	human	PROPN
admet-276	245	52	pk	pk	PROPN
admet-276	245	53	projection	projection	NOUN
admet-276	245	54	has	have	AUX
admet-276	245	55	been	be	AUX
admet-276	245	56	proposed	propose	VERB
admet-276	245	57	recently	recently	ADV
admet-276	245	58	[	[	X
admet-276	245	59	104	104	NUM
admet-276	245	60	]	]	PUNCT
admet-276	245	61	.	.	PUNCT
admet-276	246	1	for	for	ADP
admet-276	246	2	lms	lm	NOUN
admet-276	246	3	with	with	ADP
admet-276	246	4	a	a	DET
admet-276	246	5	nonlinear	nonlinear	ADJ
admet-276	246	6	pk	pk	NOUN
admet-276	246	7	involved	involve	VERB
admet-276	246	8	in	in	ADP
admet-276	246	9	the	the	DET
admet-276	246	10	tmdd	tmdd	PROPN
admet-276	246	11	process	process	NOUN
admet-276	246	12	,	,	PUNCT
admet-276	246	13	the	the	DET
admet-276	246	14	predictability	predictability	NOUN
admet-276	246	15	of	of	ADP
admet-276	246	16	plasma	plasma	NOUN
admet-276	246	17	and	and	CCONJ
admet-276	246	18	tissue	tissue	NOUN
admet-276	246	19	pk	pk	NOUN
admet-276	246	20	can	can	AUX
admet-276	246	21	be	be	AUX
admet-276	246	22	much	much	ADV
admet-276	246	23	more	more	ADV
admet-276	246	24	challenging	challenging	ADJ
admet-276	246	25	particularly	particularly	ADV
admet-276	246	26	for	for	ADP
admet-276	246	27	adcs	adcs	ADJ
admet-276	246	28	.	.	PUNCT
admet-276	247	1	despite	despite	SCONJ
admet-276	247	2	this	this	DET
admet-276	247	3	complexity	complexity	NOUN
admet-276	247	4	,	,	PUNCT
admet-276	247	5	a	a	DET
admet-276	247	6	mechanistic	mechanistic	ADJ
admet-276	247	7	framework	framework	NOUN
admet-276	247	8	based	base	VERB
admet-276	247	9	on	on	ADP
admet-276	247	10	tmdd	tmdd	PROPN
admet-276	247	11	model	model	NOUN
admet-276	247	12	was	be	AUX
admet-276	247	13	proposed	propose	VERB
admet-276	247	14	to	to	PART
admet-276	247	15	describe	describe	VERB
admet-276	247	16	the	the	DET
admet-276	247	17	pk	pk	NOUN
admet-276	247	18	of	of	ADP
admet-276	247	19	adcs	adcs	ADV
admet-276	247	20	and	and	CCONJ
admet-276	247	21	simulate	simulate	VERB
admet-276	247	22	the	the	DET
admet-276	247	23	pk	pk	NOUN
admet-276	247	24	of	of	ADP
admet-276	247	25	t	t	PROPN
admet-276	247	26	-	-	PUNCT
admet-276	247	27	dm1	dm1	PROPN
admet-276	247	28	as	as	ADP
admet-276	247	29	the	the	DET
admet-276	247	30	example	example	NOUN
admet-276	248	1	[	[	X
admet-276	248	2	105	105	NUM
admet-276	248	3	]	]	PUNCT
admet-276	248	4	.	.	PUNCT
admet-276	249	1	chen	chen	PROPN
admet-276	249	2	et	et	PROPN
admet-276	249	3	al	al	PROPN
admet-276	249	4	.	.	PUNCT
admet-276	250	1	[	[	X
admet-276	250	2	106	106	NUM
admet-276	250	3	]	]	PUNCT
admet-276	250	4	have	have	AUX
admet-276	250	5	utilized	utilize	VERB
admet-276	250	6	the	the	DET
admet-276	250	7	pbpk	pbpk	NOUN
admet-276	250	8	modeling	modeling	NOUN
admet-276	250	9	as	as	ADP
admet-276	250	10	a	a	DET
admet-276	250	11	tool	tool	NOUN
admet-276	250	12	to	to	PART
admet-276	250	13	predict	predict	VERB
admet-276	250	14	mmae	mmae	NOUN
admet-276	250	15	-	-	PUNCT
admet-276	250	16	based	base	VERB
admet-276	250	17	ddi	ddi	ADJ
admet-276	250	18	potential	potential	ADJ
admet-276	250	19	drug	drug	NOUN
admet-276	250	20	interactions	interaction	NOUN
admet-276	250	21	of	of	ADP
admet-276	250	22	adcs	adcs	NOUN
admet-276	250	23	in	in	ADP
admet-276	250	24	good	good	ADJ
admet-276	250	25	agreement	agreement	NOUN
admet-276	250	26	with	with	ADP
admet-276	250	27	the	the	DET
admet-276	250	28	observed	observe	VERB
admet-276	250	29	data	datum	NOUN
admet-276	250	30	from	from	ADP
admet-276	250	31	clinical	clinical	ADJ
admet-276	250	32	ddi	ddi	PROPN
admet-276	250	33	data	datum	NOUN
admet-276	250	34	.	.	PUNCT
admet-276	251	1	in	in	ADP
admet-276	251	2	our	our	PRON
admet-276	251	3	preliminary	preliminary	ADJ
admet-276	251	4	analysis	analysis	NOUN
admet-276	251	5	of	of	ADP
admet-276	251	6	two	two	NUM
admet-276	251	7	approved	approve	VERB
admet-276	251	8	adcs	adc	NOUN
admet-276	251	9	,	,	PUNCT
admet-276	251	10	it	it	PRON
admet-276	251	11	seems	seem	VERB
admet-276	251	12	no	no	DET
admet-276	251	13	linear	linear	ADJ
admet-276	251	14	regression	regression	NOUN
admet-276	251	15	between	between	ADP
admet-276	251	16	log(cl	log(cl	NOUN
admet-276	251	17	)	)	PUNCT
admet-276	251	18	and	and	CCONJ
admet-276	251	19	log(bw	log(bw	NOUN
admet-276	251	20	)	)	PUNCT
admet-276	251	21	cross	cross	VERB
admet-276	251	22	species	specie	NOUN
admet-276	251	23	when	when	SCONJ
admet-276	251	24	performing	perform	VERB
admet-276	251	25	an	an	DET
admet-276	251	26	allometric	allometric	ADJ
admet-276	251	27	scaling	scaling	NOUN
admet-276	251	28	for	for	ADP
admet-276	251	29	either	either	PRON
admet-276	251	30	sgn-35	sgn-35	PRON
admet-276	251	31	or	or	CCONJ
admet-276	251	32	t	t	PROPN
admet-276	251	33	-	-	PUNCT
admet-276	251	34	dm1	dm1	NOUN
admet-276	251	35	based	base	VERB
admet-276	251	36	on	on	ADP
admet-276	251	37	data	datum	NOUN
admet-276	251	38	in	in	ADP
admet-276	251	39	table	table	NOUN
admet-276	251	40	2	2	NUM
admet-276	251	41	(	(	PUNCT
admet-276	251	42	further	further	ADJ
admet-276	251	43	analysis	analysis	NOUN
admet-276	251	44	is	be	AUX
admet-276	251	45	under	under	ADP
admet-276	251	46	way	way	NOUN
admet-276	251	47	)	)	PUNCT
admet-276	251	48	.	.	PUNCT
admet-276	252	1	this	this	PRON
admet-276	252	2	may	may	AUX
admet-276	252	3	highlights	highlight	VERB
admet-276	252	4	an	an	DET
admet-276	252	5	example	example	NOUN
admet-276	252	6	of	of	ADP
admet-276	252	7	an	an	DET
admet-276	252	8	unpredictable	unpredictable	ADJ
admet-276	252	9	human	human	ADJ
admet-276	252	10	clearance	clearance	NOUN
admet-276	252	11	(	(	PUNCT
admet-276	252	12	cl	cl	NOUN
admet-276	252	13	)	)	PUNCT
admet-276	252	14	from	from	ADP
admet-276	252	15	preclinical	preclinical	ADJ
admet-276	252	16	animal	animal	NOUN
admet-276	252	17	pk	pk	NOUN
admet-276	252	18	data	datum	NOUN
admet-276	252	19	by	by	ADP
admet-276	252	20	allometric	allometric	ADJ
admet-276	252	21	scaling	scaling	NOUN
admet-276	252	22	approach	approach	NOUN
admet-276	252	23	,	,	PUNCT
admet-276	252	24	or	or	CCONJ
admet-276	252	25	at	at	ADP
admet-276	252	26	least	least	ADJ
admet-276	252	27	for	for	ADP
admet-276	252	28	these	these	DET
admet-276	252	29	two	two	NUM
admet-276	252	30	marked	mark	VERB
admet-276	252	31	adc	adc	PROPN
admet-276	252	32	drugs	drug	NOUN
admet-276	252	33	examined	examine	VERB
admet-276	252	34	herein	herein	NOUN
admet-276	252	35	,	,	PUNCT
admet-276	252	36	due	due	ADP
admet-276	252	37	to	to	ADP
admet-276	252	38	in	in	ADP
admet-276	252	39	different	different	ADJ
admet-276	252	40	clearance	clearance	NOUN
admet-276	252	41	mechanisms	mechanism	NOUN
admet-276	252	42	of	of	ADP
admet-276	252	43	adcs	adcs	PROPN
admet-276	252	44	and	and	CCONJ
admet-276	252	45	sms	sm	NOUN
admet-276	252	46	.	.	PUNCT
admet-276	253	1	furthermore	furthermore	ADV
admet-276	253	2	,	,	PUNCT
admet-276	253	3	in	in	ADP
admet-276	253	4	view	view	NOUN
admet-276	253	5	of	of	ADP
admet-276	253	6	preclinical	preclinical	ADJ
admet-276	253	7	animal	animal	NOUN
admet-276	253	8	pk	pk	NOUN
admet-276	253	9	data	datum	NOUN
admet-276	253	10	and	and	CCONJ
admet-276	253	11	human	human	ADJ
admet-276	253	12	pk	pk	NOUN
admet-276	253	13	behaviors	behavior	NOUN
admet-276	253	14	of	of	ADP
admet-276	253	15	adcetris	adcetris	NOUN
admet-276	253	16	(	(	PUNCT
admet-276	253	17	sgn-35	sgn-35	NOUN
admet-276	253	18	)	)	PUNCT
admet-276	253	19	and	and	CCONJ
admet-276	253	20	kadcyla	kadcyla	NOUN
admet-276	253	21	(	(	PUNCT
admet-276	253	22	t	t	NOUN
admet-276	253	23	-	-	PUNCT
admet-276	253	24	d1	d1	NOUN
admet-276	253	25	)	)	PUNCT
admet-276	253	26	at	at	ADP
admet-276	253	27	two	two	NUM
admet-276	253	28	representative	representative	ADJ
admet-276	253	29	doses	dose	NOUN
admet-276	253	30	as	as	SCONJ
admet-276	253	31	summarized	summarize	VERB
admet-276	253	32	in	in	ADP
admet-276	253	33	table	table	NOUN
admet-276	253	34	2	2	NUM
admet-276	253	35	,	,	PUNCT
admet-276	253	36	it	it	PRON
admet-276	253	37	appears	appear	VERB
admet-276	253	38	that	that	SCONJ
admet-276	253	39	the	the	DET
admet-276	253	40	half	half	ADJ
admet-276	253	41	-	-	PUNCT
admet-276	253	42	lives	life	NOUN
admet-276	253	43	of	of	ADP
admet-276	253	44	both	both	DET
admet-276	253	45	adcs	adcs	ADJ
admet-276	253	46	in	in	ADP
admet-276	253	47	human	human	NOUN
admet-276	253	48	are	be	AUX
admet-276	253	49	relatively	relatively	ADV
admet-276	253	50	shorter	short	ADJ
admet-276	253	51	than	than	ADP
admet-276	253	52	in	in	ADP
admet-276	253	53	rodent	rodent	ADJ
admet-276	253	54	species	specie	NOUN
admet-276	253	55	such	such	ADJ
admet-276	253	56	as	as	ADP
admet-276	253	57	mouse	mouse	NOUN
admet-276	253	58	and	and	CCONJ
admet-276	253	59	rats	rat	NOUN
admet-276	253	60	,	,	PUNCT
admet-276	253	61	but	but	CCONJ
admet-276	253	62	closer	close	ADV
admet-276	253	63	to	to	ADP
admet-276	253	64	monkey	monkey	NOUN
admet-276	253	65	.	.	PUNCT
admet-276	254	1	also	also	ADV
admet-276	254	2	,	,	PUNCT
admet-276	254	3	it	it	PRON
admet-276	254	4	should	should	AUX
admet-276	254	5	be	be	AUX
admet-276	254	6	pointed	point	VERB
admet-276	254	7	out	out	ADP
admet-276	254	8	that	that	SCONJ
admet-276	254	9	some	some	PRON
admet-276	254	10	of	of	ADP
admet-276	254	11	reported	report	VERB
admet-276	254	12	t1/2	t1/2	ADJ
admet-276	254	13	data	datum	NOUN
admet-276	254	14	are	be	AUX
admet-276	254	15	not	not	PART
admet-276	254	16	consistent	consistent	ADJ
admet-276	254	17	with	with	ADP
admet-276	254	18	the	the	DET
admet-276	254	19	calculated	calculated	ADJ
admet-276	254	20	t1/2	t1/2	ADJ
admet-276	254	21	values	value	NOUN
admet-276	254	22	resulting	result	VERB
admet-276	254	23	from	from	ADP
admet-276	254	24	a	a	DET
admet-276	254	25	relationship	relationship	NOUN
admet-276	254	26	of	of	ADP
admet-276	254	27	vd	vd	NOUN
admet-276	254	28	and	and	CCONJ
admet-276	254	29	cl	cl	NOUN
admet-276	254	30	,	,	PUNCT
admet-276	254	31	i.e.	i.e.	X
admet-276	254	32	,	,	PUNCT
admet-276	254	33	(	(	PUNCT
admet-276	254	34	t1/2=0.693×vd	t1/2=0.693×vd	X
admet-276	254	35	/	/	SYM
admet-276	254	36	cl	cl	NOUN
admet-276	254	37	)	)	PUNCT
admet-276	254	38	,	,	PUNCT
admet-276	254	39	reflecting	reflect	VERB
admet-276	254	40	the	the	DET
admet-276	254	41	different	different	ADJ
admet-276	254	42	ways	way	NOUN
admet-276	254	43	in	in	ADP
admet-276	254	44	calculating	calculate	VERB
admet-276	254	45	and	and	CCONJ
admet-276	254	46	reporting	report	VERB
admet-276	254	47	t1/2	t1/2	NOUN
admet-276	254	48	.	.	PUNCT
admet-276	255	1	bear	bear	NOUN
admet-276	255	2	in	in	ADP
admet-276	255	3	mind	mind	NOUN
admet-276	255	4	that	that	SCONJ
admet-276	255	5	the	the	DET
admet-276	255	6	application	application	NOUN
admet-276	255	7	of	of	ADP
admet-276	255	8	different	different	ADJ
admet-276	255	9	compartmental	compartmental	ADJ
admet-276	255	10	models	model	NOUN
admet-276	255	11	can	can	AUX
admet-276	255	12	result	result	VERB
admet-276	255	13	in	in	ADP
admet-276	255	14	various	various	ADJ
admet-276	255	15	half	half	ADJ
admet-276	255	16	-	-	PUNCT
admet-276	255	17	lives	life	NOUN
admet-276	255	18	,	,	PUNCT
admet-276	255	19	e.g.	e.g.	ADV
admet-276	255	20	,	,	PUNCT
admet-276	255	21	distribution	distribution	NOUN
admet-276	255	22	half	half	ADJ
admet-276	255	23	-	-	PUNCT
admet-276	255	24	life	life	NOUN
admet-276	255	25	,	,	PUNCT
admet-276	255	26	elimination	elimination	NOUN
admet-276	255	27	or	or	CCONJ
admet-276	255	28	terminal	terminal	ADJ
admet-276	255	29	half	half	ADJ
admet-276	255	30	-	-	PUNCT
admet-276	255	31	life	life	NOUN
admet-276	255	32	,	,	PUNCT
admet-276	255	33	which	which	PRON
admet-276	255	34	should	should	AUX
admet-276	255	35	be	be	AUX
admet-276	255	36	clarified	clarify	VERB
admet-276	255	37	in	in	ADP
admet-276	255	38	pk	pk	NOUN
admet-276	255	39	calculations	calculation	NOUN
admet-276	255	40	.	.	PUNCT
admet-276	256	1	thus	thus	ADV
admet-276	256	2	,	,	PUNCT
admet-276	256	3	it	it	PRON
admet-276	256	4	is	be	AUX
admet-276	256	5	important	important	ADJ
admet-276	256	6	to	to	PART
admet-276	256	7	ensure	ensure	VERB
admet-276	256	8	the	the	DET
admet-276	256	9	reported	reported	ADJ
admet-276	256	10	t1/2	t1/2	ADJ
admet-276	256	11	data	datum	NOUN
admet-276	256	12	in	in	ADP
admet-276	256	13	line	line	NOUN
admet-276	256	14	with	with	ADP
admet-276	256	15	the	the	DET
admet-276	256	16	decline	decline	NOUN
admet-276	256	17	of	of	ADP
admet-276	256	18	plasma	plasma	NOUN
admet-276	256	19	concentration	concentration	NOUN
admet-276	256	20	in	in	ADP
admet-276	256	21	order	order	NOUN
admet-276	256	22	to	to	PART
admet-276	256	23	correctly	correctly	ADV
admet-276	256	24	interpret	interpret	VERB
admet-276	256	25	dosing	dose	VERB
admet-276	256	26	regimen	regiman	NOUN
admet-276	256	27	as	as	ADV
admet-276	256	28	well	well	ADV
admet-276	256	29	as	as	ADP
admet-276	256	30	pk	pk	NOUN
admet-276	256	31	/	/	SYM
admet-276	256	32	pd	pd	NOUN
admet-276	256	33	relation	relation	NOUN
admet-276	256	34	as	as	SCONJ
admet-276	256	35	addressed	address	VERB
admet-276	256	36	above	above	ADV
admet-276	256	37	.	.	PUNCT
admet-276	257	1	moreover	moreover	ADV
admet-276	257	2	,	,	PUNCT
admet-276	257	3	as	as	SCONJ
admet-276	257	4	shown	show	VERB
admet-276	257	5	in	in	ADP
admet-276	257	6	table	table	NOUN
admet-276	257	7	2	2	NUM
admet-276	257	8	,	,	PUNCT
admet-276	257	9	an	an	DET
admet-276	257	10	increased	increase	VERB
admet-276	257	11	dose	dose	NOUN
admet-276	257	12	generally	generally	ADV
admet-276	257	13	results	result	VERB
admet-276	257	14	in	in	ADP
admet-276	257	15	an	an	DET
admet-276	257	16	increased	increase	VERB
admet-276	257	17	t1/2	t1/2	NOUN
admet-276	257	18	as	as	ADP
admet-276	257	19	a	a	DET
admet-276	257	20	result	result	NOUN
admet-276	257	21	of	of	ADP
admet-276	257	22	a	a	DET
admet-276	257	23	decreased	decrease	VERB
admet-276	257	24	cl	cl	NOUN
admet-276	257	25	and	and	CCONJ
admet-276	257	26	slightly	slightly	ADV
admet-276	257	27	increased	increase	VERB
admet-276	257	28	vd	vd	NOUN
admet-276	257	29	in	in	ADP
admet-276	257	30	both	both	DET
admet-276	257	31	preclinical	preclinical	ADJ
admet-276	257	32	species	specie	NOUN
admet-276	257	33	and	and	CCONJ
admet-276	257	34	human	human	NOUN
admet-276	257	35	.	.	PUNCT
admet-276	258	1	this	this	PRON
admet-276	258	2	may	may	AUX
admet-276	258	3	be	be	AUX
admet-276	258	4	explained	explain	VERB
admet-276	258	5	by	by	ADP
admet-276	258	6	complex	complex	ADJ
admet-276	258	7	clearance	clearance	NOUN
admet-276	258	8	mechanisms	mechanism	NOUN
admet-276	258	9	of	of	ADP
admet-276	258	10	biologics	biologic	NOUN
admet-276	258	11	by	by	ADP
admet-276	258	12	their	their	PRON
admet-276	258	13	specific	specific	ADJ
admet-276	258	14	interactions	interaction	NOUN
admet-276	258	15	with	with	ADP
admet-276	258	16	cellular	cellular	ADJ
admet-276	258	17	receptors	receptor	NOUN
admet-276	258	18	or	or	CCONJ
admet-276	258	19	described	describe	VERB
admet-276	258	20	as	as	ADP
admet-276	258	21	“	"	PUNCT
admet-276	258	22	tmdd	tmdd	PROPN
admet-276	258	23	”	"	PUNCT
admet-276	259	1	[	[	X
admet-276	259	2	11	11	NUM
admet-276	259	3	]	]	PUNCT
admet-276	259	4	,	,	PUNCT
admet-276	259	5	in	in	ADP
admet-276	259	6	addition	addition	NOUN
admet-276	259	7	to	to	ADP
admet-276	259	8	possible	possible	ADJ
admet-276	259	9	cyp	cyp	ADJ
admet-276	259	10	metabolism	metabolism	NOUN
admet-276	259	11	resulting	result	VERB
admet-276	259	12	from	from	ADP
admet-276	259	13	cytotoxin	cytotoxin	NOUN
admet-276	259	14	.	.	PUNCT
admet-276	260	1	more	more	ADV
admet-276	260	2	specifically	specifically	ADV
admet-276	260	3	,	,	PUNCT
admet-276	260	4	once	once	ADV
admet-276	260	5	bound	bind	VERB
admet-276	260	6	,	,	PUNCT
admet-276	260	7	drugs	drug	NOUN
admet-276	260	8	mainly	mainly	ADV
admet-276	260	9	undergo	undergo	VERB
admet-276	260	10	endocytosis	endocytosis	NOUN
admet-276	260	11	and	and	CCONJ
admet-276	260	12	subsequent	subsequent	ADJ
admet-276	260	13	lysosomal	lysosomal	ADJ
admet-276	260	14	degradation	degradation	NOUN
admet-276	260	15	,	,	PUNCT
admet-276	260	16	dependent	dependent	ADJ
admet-276	260	17	on	on	ADP
admet-276	260	18	the	the	DET
admet-276	260	19	ratio	ratio	NOUN
admet-276	260	20	of	of	ADP
admet-276	260	21	receptor	receptor	NOUN
admet-276	260	22	/	/	SYM
admet-276	260	23	drug	drug	NOUN
admet-276	260	24	concentration	concentration	NOUN
admet-276	260	25	,	,	PUNCT
admet-276	260	26	i.e.	i.e.	X
admet-276	260	27	,	,	PUNCT
admet-276	260	28	as	as	SCONJ
admet-276	260	29	the	the	DET
admet-276	260	30	drug	drug	NOUN
admet-276	260	31	level	level	NOUN
admet-276	260	32	increases	increase	NOUN
admet-276	260	33	or	or	CCONJ
admet-276	260	34	the	the	DET
admet-276	260	35	number	number	NOUN
admet-276	260	36	of	of	ADP
admet-276	260	37	receptors	receptor	NOUN
admet-276	260	38	diminishes	diminish	VERB
admet-276	260	39	,	,	PUNCT
admet-276	260	40	the	the	DET
admet-276	260	41	proportion	proportion	NOUN
admet-276	260	42	of	of	ADP
admet-276	260	43	drug	drug	NOUN
admet-276	260	44	internalized	internalize	VERB
admet-276	260	45	and	and	CCONJ
admet-276	260	46	metabolized	metabolize	VERB
admet-276	260	47	decreases	decrease	NOUN
admet-276	260	48	,	,	PUNCT
admet-276	260	49	contributing	contribute	VERB
admet-276	260	50	to	to	ADP
admet-276	260	51	a	a	DET
admet-276	260	52	lower	low	ADJ
admet-276	260	53	clearance	clearance	NOUN
admet-276	260	54	and	and	CCONJ
admet-276	260	55	consequently	consequently	ADV
admet-276	260	56	longer	long	ADJ
admet-276	260	57	half	half	ADJ
admet-276	260	58	-	-	PUNCT
admet-276	260	59	lives	life	NOUN
admet-276	260	60	.	.	PUNCT
admet-276	261	1	furthermore	furthermore	ADV
admet-276	261	2	,	,	PUNCT
admet-276	261	3	both	both	CCONJ
admet-276	261	4	auc	auc	VERB
admet-276	261	5	and	and	CCONJ
admet-276	261	6	cmax	cmax	NOUN
admet-276	261	7	’s	’s	PART
admet-276	261	8	increment	increment	NOUN
admet-276	261	9	of	of	ADP
admet-276	261	10	two	two	NUM
admet-276	261	11	adcs	adcs	ADJ
admet-276	261	12	is	be	AUX
admet-276	261	13	greater	great	ADJ
admet-276	261	14	than	than	SCONJ
admet-276	261	15	dose	dose	VERB
admet-276	261	16	proportional	proportional	NOUN
admet-276	261	17	when	when	SCONJ
admet-276	261	18	dose	dose	NOUN
admet-276	261	19	increases	increase	NOUN
admet-276	261	20	in	in	ADP
admet-276	261	21	both	both	DET
admet-276	261	22	preclinical	preclinical	ADJ
admet-276	261	23	species	specie	NOUN
admet-276	261	24	and	and	CCONJ
admet-276	261	25	human	human	NOUN
admet-276	261	26	.	.	PUNCT
admet-276	262	1	however	however	ADV
admet-276	262	2	,	,	PUNCT
admet-276	262	3	no	no	DET
admet-276	262	4	obvious	obvious	ADJ
admet-276	262	5	accumulations	accumulation	NOUN
admet-276	262	6	were	be	AUX
admet-276	262	7	observed	observe	VERB
admet-276	262	8	in	in	ADP
admet-276	262	9	tk	tk	PROPN
admet-276	262	10	analysis	analysis	NOUN
admet-276	262	11	,	,	PUNCT
admet-276	262	12	which	which	PRON
admet-276	262	13	is	be	AUX
admet-276	262	14	different	different	ADJ
admet-276	262	15	from	from	ADP
admet-276	262	16	small	small	ADJ
admet-276	262	17	molecule	molecule	NOUN
admet-276	262	18	drugs	drug	NOUN
admet-276	262	19	wherein	wherein	ADJ
admet-276	262	20	drug	drug	NOUN
admet-276	262	21	accumulation	accumulation	NOUN
admet-276	262	22	could	could	AUX
admet-276	262	23	often	often	ADV
admet-276	262	24	occurs	occur	VERB
admet-276	262	25	when	when	SCONJ
admet-276	262	26	the	the	DET
admet-276	262	27	cyp	cyp	ADJ
admet-276	262	28	metabolism	metabolism	NOUN
admet-276	262	29	enzymes	enzyme	NOUN
admet-276	262	30	could	could	AUX
admet-276	262	31	be	be	AUX
admet-276	262	32	saturated	saturate	VERB
admet-276	262	33	at	at	ADP
admet-276	262	34	higher	high	ADJ
admet-276	262	35	doses	dose	NOUN
admet-276	262	36	by	by	ADP
admet-276	262	37	non	non	ADJ
admet-276	262	38	-	-	ADJ
admet-276	262	39	linear	linear	ADJ
admet-276	262	40	exposure	exposure	NOUN
admet-276	262	41	especially	especially	ADV
admet-276	262	42	for	for	ADP
admet-276	262	43	low	low	ADJ
admet-276	262	44	clearance	clearance	NOUN
admet-276	262	45	compounds	compound	NOUN
admet-276	262	46	.	.	PUNCT
admet-276	263	1	on	on	ADP
admet-276	263	2	the	the	DET
admet-276	263	3	other	other	ADJ
admet-276	263	4	hand	hand	NOUN
admet-276	263	5	,	,	PUNCT
admet-276	263	6	from	from	ADP
admet-276	263	7	pk	pk	NOUN
admet-276	263	8	/	/	SYM
admet-276	263	9	pd	pd	PROPN
admet-276	263	10	perspective	perspective	NOUN
admet-276	263	11	,	,	PUNCT
admet-276	263	12	it	it	PRON
admet-276	263	13	is	be	AUX
admet-276	263	14	generally	generally	ADV
admet-276	263	15	accepted	accept	VERB
admet-276	263	16	that	that	SCONJ
admet-276	263	17	small	small	ADJ
admet-276	263	18	drug	drug	NOUN
admet-276	263	19	molecules	molecule	NOUN
admet-276	263	20	are	be	AUX
admet-276	263	21	rapidly	rapidly	ADV
admet-276	263	22	equilibrated	equilibrate	VERB
admet-276	263	23	at	at	ADP
admet-276	263	24	steady	steady	ADJ
admet-276	263	25	state	state	NOUN
admet-276	263	26	with	with	ADP
admet-276	263	27	the	the	DET
admet-276	263	28	same	same	ADJ
admet-276	263	29	free	free	ADJ
admet-276	263	30	concentration	concentration	NOUN
admet-276	263	31	(	(	PUNCT
admet-276	263	32	unbound	unbound	NOUN
admet-276	263	33	)	)	PUNCT
admet-276	263	34	between	between	ADP
admet-276	263	35	plasma	plasma	NOUN
admet-276	263	36	and	and	CCONJ
admet-276	263	37	tissues	tissue	NOUN
admet-276	263	38	,	,	PUNCT
admet-276	263	39	which	which	PRON
admet-276	263	40	means	mean	VERB
admet-276	263	41	that	that	SCONJ
admet-276	263	42	pk	pk	PROPN
admet-276	263	43	/	/	SYM
admet-276	263	44	pd	pd	NOUN
admet-276	263	45	can	can	AUX
admet-276	263	46	be	be	AUX
admet-276	263	47	assessed	assess	VERB
admet-276	263	48	based	base	VERB
admet-276	263	49	on	on	ADP
admet-276	263	50	free	free	ADJ
admet-276	263	51	plasma	plasma	NOUN
admet-276	263	52	concentrations	concentration	NOUN
admet-276	263	53	without	without	ADP
admet-276	263	54	measuring	measure	VERB
admet-276	263	55	tissue	tissue	NOUN
admet-276	263	56	levels	level	NOUN
admet-276	263	57	.	.	PUNCT
admet-276	264	1	in	in	ADP
admet-276	264	2	contrast	contrast	NOUN
admet-276	264	3	,	,	PUNCT
admet-276	264	4	therapeutic	therapeutic	ADJ
admet-276	264	5	biologics	biologic	NOUN
admet-276	264	6	generally	generally	ADV
admet-276	264	7	with	with	ADP
admet-276	264	8	limited	limited	ADJ
admet-276	264	9	and	and	CCONJ
admet-276	264	10	variable	variable	ADJ
admet-276	264	11	distribution	distribution	NOUN
admet-276	264	12	in	in	ADP
admet-276	264	13	tissues	tissue	NOUN
admet-276	264	14	,	,	PUNCT
admet-276	264	15	and	and	CCONJ
admet-276	264	16	serum	serum	NOUN
admet-276	264	17	levels	level	NOUN
admet-276	264	18	are	be	AUX
admet-276	264	19	not	not	PART
admet-276	264	20	necessarily	necessarily	ADV
admet-276	264	21	predictive	predictive	ADJ
admet-276	264	22	for	for	ADP
admet-276	264	23	tissue	tissue	NOUN
admet-276	264	24	levels	level	NOUN
admet-276	264	25	.	.	PUNCT
admet-276	265	1	added	add	VERB
admet-276	265	2	to	to	ADP
admet-276	265	3	that	that	PRON
admet-276	265	4	,	,	PUNCT
admet-276	265	5	biologics	biologic	NOUN
admet-276	265	6	are	be	AUX
admet-276	265	7	administered	administer	VERB
admet-276	265	8	mainly	mainly	ADV
admet-276	265	9	parenterally	parenterally	ADV
admet-276	265	10	,	,	PUNCT
admet-276	265	11	so	so	ADV
admet-276	265	12	,	,	PUNCT
admet-276	265	13	adme	adme	NOUN
admet-276	265	14	testing	testing	NOUN
admet-276	265	15	generally	generally	ADV
admet-276	265	16	focus	focus	VERB
admet-276	265	17	on	on	ADP
admet-276	265	18	biodistribution	biodistribution	NOUN
admet-276	265	19	or	or	CCONJ
admet-276	265	20	the	the	DET
admet-276	265	21	relationship	relationship	NOUN
admet-276	265	22	between	between	ADP
admet-276	265	23	tissue	tissue	NOUN
admet-276	265	24	concentration	concentration	NOUN
admet-276	265	25	and	and	CCONJ
admet-276	265	26	efficacy	efficacy	NOUN
admet-276	265	27	.	.	PUNCT
admet-276	266	1	as	as	SCONJ
admet-276	266	2	mentioned	mention	VERB
admet-276	266	3	above	above	ADV
admet-276	266	4	,	,	PUNCT
admet-276	266	5	adcs	adcs	PROPN
admet-276	266	6	may	may	AUX
admet-276	266	7	have	have	VERB
admet-276	266	8	a	a	DET
admet-276	266	9	dose	dose	ADJ
admet-276	266	10	proportional	proportional	ADJ
admet-276	266	11	pk	pk	NOUN
admet-276	266	12	of	of	ADP
admet-276	266	13	in	in	ADP
admet-276	266	14	rats	rat	NOUN
admet-276	266	15	probably	probably	ADV
admet-276	266	16	due	due	ADP
admet-276	266	17	to	to	ADP
admet-276	266	18	no	no	DET
admet-276	266	19	specific	specific	ADJ
admet-276	266	20	binding	binding	NOUN
admet-276	266	21	/	/	SYM
admet-276	266	22	no	no	DET
admet-276	266	23	cross	cross	NOUN
admet-276	266	24	-	-	NOUN
admet-276	266	25	reactivity	reactivity	NOUN
admet-276	266	26	,	,	PUNCT
admet-276	266	27	but	but	CCONJ
admet-276	266	28	a	a	DET
admet-276	266	29	non	non	ADJ
admet-276	266	30	-	-	ADJ
admet-276	266	31	linear	linear	ADJ
admet-276	266	32	pk	pk	NOUN
admet-276	266	33	in	in	ADP
admet-276	266	34	cynomolgus	cynomolgus	ADJ
admet-276	266	35	monkeys	monkey	NOUN
admet-276	266	36	due	due	ADP
admet-276	266	37	to	to	ADP
admet-276	266	38	crossreactivity	crossreactivity	NOUN
admet-276	266	39	/	/	SYM
admet-276	266	40	specific	specific	ADJ
admet-276	266	41	binding	binding	NOUN
admet-276	266	42	.	.	PUNCT
admet-276	267	1	this	this	PRON
admet-276	267	2	has	have	AUX
admet-276	267	3	raised	raise	VERB
admet-276	267	4	a	a	DET
admet-276	267	5	challenge	challenge	NOUN
admet-276	267	6	in	in	ADP
admet-276	267	7	predicting	predict	VERB
admet-276	267	8	human	human	ADJ
admet-276	267	9	pk	pk	PROPN
admet-276	267	10	as	as	ADV
admet-276	267	11	well	well	ADV
admet-276	267	12	as	as	ADP
admet-276	267	13	human	human	ADJ
admet-276	267	14	dose	dose	NOUN
admet-276	267	15	based	base	VERB
admet-276	267	16	on	on	ADP
admet-276	267	17	traditional	traditional	ADJ
admet-276	267	18	approaches	approach	NOUN
admet-276	267	19	applied	apply	VERB
admet-276	267	20	for	for	ADP
admet-276	267	21	small	small	ADJ
admet-276	267	22	molecules	molecule	NOUN
admet-276	267	23	owing	owe	VERB
admet-276	267	24	to	to	ADP
admet-276	267	25	limited	limited	ADJ
admet-276	267	26	number	number	NOUN
admet-276	267	27	of	of	ADP
admet-276	267	28	species	specie	NOUN
admet-276	267	29	and	and	CCONJ
admet-276	267	30	crossreactivity	crossreactivity	NOUN
admet-276	267	31	.	.	PUNCT
admet-276	268	1	in	in	ADP
admet-276	268	2	other	other	ADJ
admet-276	268	3	words	word	NOUN
admet-276	268	4	,	,	PUNCT
admet-276	268	5	how	how	SCONJ
admet-276	268	6	will	will	AUX
admet-276	268	7	preclinical	preclinical	ADJ
admet-276	268	8	data	datum	NOUN
admet-276	268	9	be	be	AUX
admet-276	268	10	translated	translate	VERB
admet-276	268	11	to	to	ADP
admet-276	268	12	clinic	clinic	NOUN
admet-276	268	13	in	in	ADP
admet-276	268	14	term	term	NOUN
admet-276	268	15	of	of	ADP
admet-276	268	16	human	human	ADJ
admet-276	268	17	pk	pk	NOUN
admet-276	268	18	and	and	CCONJ
admet-276	268	19	dose	dose	PROPN
admet-276	268	20	admet	admet	PROPN
admet-276	268	21	&	&	CCONJ
admet-276	268	22	dmpk	dmpk	PROPN
admet-276	268	23	4(1	4(1	NOUN
admet-276	268	24	)	)	PUNCT
admet-276	268	25	(	(	PUNCT
admet-276	268	26	2016	2016	NUM
admet-276	268	27	)	)	PUNCT
admet-276	268	28	1	1	NUM
admet-276	268	29	-	-	SYM
admet-276	268	30	22	22	NUM
admet-276	268	31	adme	adme	NOUN
admet-276	268	32	testing	testing	NOUN
admet-276	268	33	of	of	ADP
admet-276	268	34	large	large	ADJ
admet-276	268	35	biologics	biologic	NOUN
admet-276	268	36	doi	doi	NOUN
admet-276	268	37	:	:	PUNCT
admet-276	268	38	10.5599	10.5599	NUM
admet-276	268	39	/	/	SYM
admet-276	268	40	admet.4.1.276	admet.4.1.276	NUM
admet-276	268	41	15	15	NUM
admet-276	268	42	prediction	prediction	NOUN
admet-276	268	43	?	?	PUNCT
admet-276	269	1	in	in	ADP
admet-276	269	2	order	order	NOUN
admet-276	269	3	to	to	PART
admet-276	269	4	better	well	ADV
admet-276	269	5	understand	understand	VERB
admet-276	269	6	the	the	DET
admet-276	269	7	pk	pk	PROPN
admet-276	269	8	/	/	SYM
admet-276	269	9	pd	pd	NOUN
admet-276	269	10	relationship	relationship	NOUN
admet-276	269	11	and	and	CCONJ
admet-276	269	12	toxicity	toxicity	NOUN
admet-276	269	13	profile	profile	NOUN
admet-276	269	14	of	of	ADP
admet-276	269	15	adcs	adcs	ADJ
admet-276	269	16	,	,	PUNCT
admet-276	269	17	total	total	ADJ
admet-276	269	18	mab	mab	PROPN
admet-276	269	19	,	,	PUNCT
admet-276	269	20	adc	adc	PROPN
admet-276	269	21	or	or	CCONJ
admet-276	269	22	released	release	VERB
admet-276	269	23	payload	payload	NOUN
admet-276	269	24	might	might	AUX
admet-276	269	25	need	need	VERB
admet-276	269	26	to	to	PART
admet-276	269	27	be	be	AUX
admet-276	269	28	measured	measure	VERB
admet-276	269	29	in	in	ADP
admet-276	269	30	both	both	DET
admet-276	269	31	plasma	plasma	NOUN
admet-276	269	32	and	and	CCONJ
admet-276	269	33	tumor	tumor	NOUN
admet-276	269	34	.	.	PUNCT
admet-276	270	1	in	in	ADP
admet-276	270	2	addition	addition	NOUN
admet-276	270	3	,	,	PUNCT
admet-276	270	4	conducting	conduct	VERB
admet-276	270	5	pd	pd	PROPN
admet-276	270	6	evaluations	evaluation	NOUN
admet-276	270	7	requires	require	VERB
admet-276	270	8	a	a	DET
admet-276	270	9	clear	clear	ADJ
admet-276	270	10	understanding	understanding	NOUN
admet-276	270	11	of	of	ADP
admet-276	270	12	the	the	DET
admet-276	270	13	interaction	interaction	NOUN
admet-276	270	14	of	of	ADP
admet-276	270	15	mab	mab	PROPN
admet-276	270	16	/	/	SYM
admet-276	270	17	adc	adc	PROPN
admet-276	270	18	with	with	ADP
admet-276	270	19	the	the	DET
admet-276	270	20	target	target	NOUN
admet-276	270	21	at	at	ADP
admet-276	270	22	early	early	ADJ
admet-276	270	23	stage	stage	NOUN
admet-276	270	24	as	as	ADP
admet-276	270	25	possible	possible	ADJ
admet-276	270	26	,	,	PUNCT
admet-276	270	27	which	which	PRON
admet-276	270	28	may	may	AUX
admet-276	270	29	help	help	VERB
admet-276	270	30	pk	pk	PROPN
admet-276	270	31	/	/	SYM
admet-276	270	32	pd	pd	PROPN
admet-276	270	33	for	for	ADP
admet-276	270	34	human	human	ADJ
admet-276	270	35	efficacy	efficacy	NOUN
admet-276	270	36	and	and	CCONJ
admet-276	270	37	dose	dose	NOUN
admet-276	270	38	prediction	prediction	NOUN
admet-276	270	39	.	.	PUNCT
admet-276	271	1	pk	pk	PROPN
admet-276	271	2	/	/	SYM
admet-276	271	3	pd	pd	NOUN
admet-276	271	4	modeling	modeling	NOUN
admet-276	271	5	and	and	CCONJ
admet-276	271	6	simulation	simulation	NOUN
admet-276	271	7	(	(	PUNCT
admet-276	271	8	m&s	m&s	PROPN
admet-276	271	9	)	)	PUNCT
admet-276	271	10	may	may	AUX
admet-276	271	11	provide	provide	VERB
admet-276	271	12	an	an	DET
admet-276	271	13	excellent	excellent	ADJ
admet-276	271	14	tool	tool	NOUN
admet-276	271	15	to	to	PART
admet-276	271	16	overcome	overcome	VERB
admet-276	271	17	these	these	DET
admet-276	271	18	challenges	challenge	NOUN
admet-276	271	19	,	,	PUNCT
admet-276	271	20	as	as	SCONJ
admet-276	271	21	it	it	PRON
admet-276	271	22	can	can	AUX
admet-276	271	23	simultaneously	simultaneously	ADV
admet-276	271	24	integrate	integrate	VERB
admet-276	271	25	the	the	DET
admet-276	271	26	pk	pk	NOUN
admet-276	271	27	/	/	SYM
admet-276	271	28	pd	pd	PROPN
admet-276	271	29	of	of	ADP
admet-276	271	30	adcs	adcs	PROPN
admet-276	271	31	and	and	CCONJ
admet-276	271	32	their	their	PRON
admet-276	271	33	components	component	NOUN
admet-276	271	34	in	in	ADP
admet-276	271	35	a	a	DET
admet-276	271	36	quantitative	quantitative	ADJ
admet-276	271	37	manner	manner	NOUN
admet-276	272	1	[	[	X
admet-276	272	2	111,112	111,112	NUM
admet-276	272	3	]	]	PUNCT
admet-276	272	4	.	.	PUNCT
admet-276	273	1	additionally	additionally	ADV
admet-276	273	2	,	,	PUNCT
admet-276	273	3	the	the	DET
admet-276	273	4	computational	computational	ADJ
admet-276	273	5	pk	pk	NOUN
admet-276	273	6	/	/	SYM
admet-276	273	7	pd	pd	NOUN
admet-276	273	8	models	model	NOUN
admet-276	273	9	can	can	AUX
admet-276	273	10	also	also	ADV
admet-276	273	11	serve	serve	VERB
admet-276	273	12	as	as	ADP
admet-276	273	13	a	a	DET
admet-276	273	14	cornerstone	cornerstone	NOUN
admet-276	273	15	for	for	ADP
admet-276	273	16	the	the	DET
admet-276	273	17	model	model	NOUN
admet-276	273	18	-	-	PUNCT
admet-276	273	19	based	base	VERB
admet-276	273	20	drug	drug	NOUN
admet-276	273	21	development	development	NOUN
admet-276	273	22	and	and	CCONJ
admet-276	273	23	preclinical	preclinical	ADJ
admet-276	273	24	-	-	PUNCT
admet-276	273	25	toclinical	toclinical	NOUN
admet-276	273	26	translation	translation	NOUN
admet-276	273	27	of	of	ADP
admet-276	273	28	adcs	adcs	PROPN
admet-276	273	29	.	.	PUNCT
admet-276	274	1	for	for	ADP
admet-276	274	2	instance	instance	NOUN
admet-276	274	3	,	,	PUNCT
admet-276	274	4	shah	shah	PROPN
admet-276	274	5	et	et	PROPN
admet-276	274	6	al	al	PROPN
admet-276	274	7	.	.	PROPN
admet-276	274	8	has	have	AUX
admet-276	274	9	developed	develop	VERB
admet-276	274	10	a	a	DET
admet-276	274	11	mechanistic	mechanistic	ADJ
admet-276	274	12	model	model	NOUN
admet-276	274	13	able	able	ADJ
admet-276	274	14	to	to	PART
admet-276	274	15	predict	predict	VERB
admet-276	274	16	clinical	clinical	ADJ
admet-276	274	17	response	response	NOUN
admet-276	274	18	by	by	ADP
admet-276	274	19	integrating	integrate	VERB
admet-276	274	20	all	all	DET
admet-276	274	21	preclinical	preclinical	ADJ
admet-276	274	22	biomeasures	biomeasure	NOUN
admet-276	274	23	and	and	CCONJ
admet-276	274	24	pk	pk	PROPN
admet-276	274	25	/	/	SYM
admet-276	274	26	pd	pd	NOUN
admet-276	274	27	data	datum	NOUN
admet-276	274	28	of	of	ADP
admet-276	274	29	brentuximab	brentuximab	NOUN
admet-276	274	30	-	-	PUNCT
admet-276	274	31	vedotin	vedotin	NOUN
admet-276	274	32	[	[	X
admet-276	274	33	113	113	NUM
admet-276	274	34	]	]	PUNCT
admet-276	274	35	.	.	PUNCT
admet-276	275	1	khot	khot	AUX
admet-276	275	2	et	et	PROPN
admet-276	275	3	al	al	PROPN
admet-276	275	4	.	.	PROPN
admet-276	275	5	highlighted	highlight	VERB
admet-276	275	6	the	the	DET
admet-276	275	7	applications	application	NOUN
admet-276	275	8	of	of	ADP
admet-276	275	9	m&s	m&s	NOUN
admet-276	275	10	to	to	PART
admet-276	275	11	gain	gain	VERB
admet-276	275	12	distinct	distinct	ADJ
admet-276	275	13	insights	insight	NOUN
admet-276	275	14	into	into	ADP
admet-276	275	15	adc	adc	PROPN
admet-276	275	16	development	development	NOUN
admet-276	275	17	for	for	ADP
admet-276	275	18	pk	pk	PROPN
admet-276	275	19	/	/	SYM
admet-276	275	20	pd	pd	NOUN
admet-276	275	21	and	and	CCONJ
admet-276	275	22	toxicodynamic	toxicodynamic	PROPN
admet-276	275	23	data	datum	NOUN
admet-276	275	24	by	by	ADP
admet-276	275	25	integrating	integrate	VERB
admet-276	275	26	a	a	DET
admet-276	275	27	diverse	diverse	ADJ
admet-276	275	28	array	array	NOUN
admet-276	275	29	of	of	ADP
admet-276	275	30	in	in	ADP
admet-276	275	31	vitro	vitro	X
admet-276	275	32	,	,	PUNCT
admet-276	275	33	preclinical	preclinical	ADJ
admet-276	275	34	and	and	CCONJ
admet-276	275	35	clinical	clinical	ADJ
admet-276	275	36	data	datum	NOUN
admet-276	275	37	generated	generate	VERB
admet-276	275	38	at	at	ADP
admet-276	275	39	different	different	ADJ
admet-276	275	40	stages	stage	NOUN
admet-276	275	41	of	of	ADP
admet-276	275	42	adc	adc	PROPN
admet-276	275	43	development	development	NOUN
admet-276	276	1	[	[	X
admet-276	276	2	114	114	NUM
admet-276	276	3	]	]	PUNCT
admet-276	276	4	.	.	PUNCT
admet-276	277	1	table	table	NOUN
admet-276	277	2	2	2	NUM
admet-276	277	3	.	.	PUNCT
admet-276	277	4	preclinical	preclinical	ADJ
admet-276	277	5	and	and	CCONJ
admet-276	277	6	human	human	ADJ
admet-276	277	7	pk	pk	NOUN
admet-276	277	8	data	datum	NOUN
admet-276	277	9	of	of	ADP
admet-276	277	10	adc	adc	PROPN
admet-276	277	11	drugs	drug	NOUN
admet-276	277	12	(	(	PUNCT
admet-276	277	13	adcetris	adcetris	NOUN
admet-276	277	14	and	and	CCONJ
admet-276	277	15	kadcyla	kadcyla	NOUN
admet-276	277	16	)	)	PUNCT
admet-276	277	17	*	*	PUNCT
admet-276	277	18	drug	drug	NOUN
admet-276	277	19	mouse	mouse	PROPN
admet-276	277	20	rat	rat	NOUN
admet-276	277	21	monkey	monkey	NOUN
admet-276	277	22	human	human	ADJ
admet-276	277	23	adcetris	adcetris	NOUN
admet-276	277	24	(	(	PUNCT
admet-276	277	25	brentuximab	brentuximab	NOUN
admet-276	277	26	vedotin	vedotin	NOUN
admet-276	277	27	,	,	PUNCT
admet-276	277	28	sgn-35	sgn-35	X
admet-276	277	29	)	)	PUNCT
admet-276	277	30	dose	dose	PROPN
admet-276	277	31	(	(	PUNCT
admet-276	277	32	mg	mg	PROPN
admet-276	277	33	kg	kg	INTJ
admet-276	277	34	-1	-1	PUNCT
admet-276	277	35	)	)	PUNCT
admet-276	277	36	10	10	NUM
admet-276	277	37	—	—	PUNCT
admet-276	277	38	0.5	0.5	NUM
admet-276	277	39	5.0	5.0	NUM
admet-276	277	40	0.3	0.3	NUM
admet-276	277	41	1.0	1.0	NUM
admet-276	277	42	1.2	1.2	NUM
admet-276	277	43	2.7	2.7	NUM
admet-276	277	44	cmax	cmax	NOUN
admet-276	277	45	(	(	PUNCT
admet-276	277	46	µg	µg	ADV
admet-276	277	47	ml	ml	NOUN
admet-276	277	48	-1	-1	PUNCT
admet-276	277	49	)	)	PUNCT
admet-276	277	50	—	—	PUNCT
admet-276	277	51	—	—	PUNCT
admet-276	277	52	13	13	NUM
admet-276	277	53	171	171	NUM
admet-276	277	54	6.9	6.9	NUM
admet-276	277	55	29.2	29.2	NUM
admet-276	277	56	18.9	18.9	NUM
admet-276	277	57	45.7	45.7	NUM
admet-276	277	58	auc(µg	auc(µg	NOUN
admet-276	277	59	ml	ml	NOUN
admet-276	277	60	-1	-1	ADJ
admet-276	277	61	day	day	NOUN
admet-276	277	62	-1	-1	CCONJ
admet-276	277	63	)	)	PUNCT
admet-276	277	64	2313	2313	NUM
admet-276	277	65	—	—	PUNCT
admet-276	277	66	20	20	NUM
admet-276	277	67	253	253	NUM
admet-276	277	68	11	11	NUM
admet-276	277	69	55.3	55.3	NUM
admet-276	277	70	46.1	46.1	NUM
admet-276	277	71	125.8	125.8	NUM
admet-276	277	72	t1/2	t1/2	PROPN
admet-276	277	73	(	(	PUNCT
admet-276	277	74	days	day	NOUN
admet-276	277	75	)	)	PUNCT
admet-276	277	76	16.9	16.9	NUM
admet-276	277	77	—	—	PUNCT
admet-276	277	78	14.6	14.6	NUM
admet-276	277	79	8.5	8.5	NUM
admet-276	277	80	1.8	1.8	NUM
admet-276	277	81	2.7	2.7	NUM
admet-276	277	82	3.8	3.8	NUM
admet-276	277	83	6.0	6.0	NUM
admet-276	277	84	t1/2	t1/2	NOUN
admet-276	277	85	(	(	PUNCT
admet-276	277	86	calculated	calculate	VERB
admet-276	277	87	)	)	PUNCT
admet-276	277	88	16.9	16.9	NUM
admet-276	277	89	—	—	PUNCT
admet-276	277	90	5.1	5.1	NUM
admet-276	277	91	4.7	4.7	NUM
admet-276	277	92	1.7	1.7	NUM
admet-276	277	93	2.5	2.5	NUM
admet-276	277	94	3.8	3.8	NUM
admet-276	277	95	6.0	6.0	NUM
admet-276	277	96	cl	cl	NOUN
admet-276	277	97	(	(	PUNCT
admet-276	277	98	ml	ml	INTJ
admet-276	277	99	day	day	NOUN
admet-276	277	100	-1	-1	INTJ
admet-276	277	101	kg	kg	INTJ
admet-276	277	102	-1	-1	PUNCT
admet-276	277	103	)	)	PUNCT
admet-276	277	104	4.4	4.4	NUM
admet-276	277	105	—	—	PUNCT
admet-276	277	106	25	25	NUM
admet-276	277	107	20	20	NUM
admet-276	277	108	27.7	27.7	NUM
admet-276	277	109	18.5	18.5	NUM
admet-276	277	110	26.0	26.0	NUM
admet-276	277	111	21.5	21.5	NUM
admet-276	277	112	vss	vss	NOUN
admet-276	277	113	(	(	PUNCT
admet-276	277	114	ml	ml	INTJ
admet-276	277	115	kg	kg	INTJ
admet-276	277	116	-1	-1	PUNCT
admet-276	277	117	)	)	PUNCT
admet-276	277	118	107	107	NUM
admet-276	277	119	—	—	PUNCT
admet-276	277	120	183	183	NUM
admet-276	277	121	135	135	NUM
admet-276	277	122	68	68	NUM
admet-276	277	123	67.4	67.4	NUM
admet-276	277	124	142	142	NUM
admet-276	277	125	186	186	NUM
admet-276	277	126	kadcyla	kadcyla	NOUN
admet-276	277	127	(	(	PUNCT
admet-276	277	128	adotrastuzumab	adotrastuzumab	NOUN
admet-276	277	129	emtansine	emtansine	NOUN
admet-276	277	130	,	,	PUNCT
admet-276	277	131	tdm1	tdm1	PROPN
admet-276	277	132	)	)	PUNCT
admet-276	277	133	dose	dose	PROPN
admet-276	277	134	(	(	PUNCT
admet-276	277	135	mg	mg	PROPN
admet-276	277	136	kg	kg	INTJ
admet-276	277	137	-1	-1	PUNCT
admet-276	277	138	)	)	PUNCT
admet-276	277	139	0.3	0.3	NUM
admet-276	277	140	15	15	NUM
admet-276	277	141	0.3	0.3	NUM
admet-276	277	142	20	20	NUM
admet-276	277	143	0.3	0.3	NUM
admet-276	277	144	3.0	3.0	NUM
admet-276	277	145	0.3	0.3	NUM
admet-276	277	146	4.8	4.8	NUM
admet-276	277	147	cmax	cmax	NOUN
admet-276	277	148	(	(	PUNCT
admet-276	277	149	µg	µg	ADV
admet-276	277	150	ml	ml	NOUN
admet-276	277	151	-1	-1	PUNCT
admet-276	277	152	)	)	PUNCT
admet-276	277	153	—	—	PUNCT
admet-276	277	154	—	—	PUNCT
admet-276	277	155	—	—	PUNCT
admet-276	277	156	—	—	PUNCT
admet-276	277	157	7.4	7.4	NUM
admet-276	277	158	74.2	74.2	NUM
admet-276	277	159	9.63	9.63	NUM
admet-276	277	160	130	130	NUM
admet-276	277	161	auc(µg	auc(µg	NOUN
admet-276	277	162	ml	ml	NOUN
admet-276	277	163	-1	-1	ADJ
admet-276	277	164	day	day	NOUN
admet-276	277	165	-1	-1	PUNCT
admet-276	277	166	)	)	PUNCT
admet-276	277	167	—	—	PUNCT
admet-276	277	168	—	—	PUNCT
admet-276	277	169	—	—	PUNCT
admet-276	277	170	—	—	PUNCT
admet-276	277	171	7.5	7.5	NUM
admet-276	277	172	180	180	NUM
admet-276	277	173	14.5	14.5	NUM
admet-276	277	174	673	673	NUM
admet-276	277	175	t1/2	t1/2	NOUN
admet-276	277	176	(	(	PUNCT
admet-276	277	177	days	day	NOUN
admet-276	277	178	)	)	PUNCT
admet-276	277	179	4.2	4.2	NUM
admet-276	277	180	13.1	13.1	NUM
admet-276	277	181	4.9	4.9	NUM
admet-276	277	182	5.4	5.4	NUM
admet-276	277	183	0.9	0.9	NUM
admet-276	277	184	2.9	2.9	NUM
admet-276	277	185	1.3	1.3	NUM
admet-276	277	186	4.1	4.1	NUM
admet-276	277	187	t1/2	t1/2	NOUN
admet-276	277	188	(	(	PUNCT
admet-276	277	189	calculated	calculate	VERB
admet-276	277	190	)	)	PUNCT
admet-276	277	191	2.2	2.2	NUM
admet-276	277	192	2.3	2.3	NUM
admet-276	277	193	5.0	5.0	NUM
admet-276	277	194	4.7	4.7	NUM
admet-276	277	195	0.8	0.8	NUM
admet-276	277	196	2.5	2.5	NUM
admet-276	277	197	1.2	1.2	NUM
admet-276	277	198	4.0	4.0	NUM
admet-276	277	199	cl	cl	NOUN
admet-276	277	200	(	(	PUNCT
admet-276	277	201	ml	ml	INTJ
admet-276	277	202	day	day	NOUN
admet-276	277	203	-1	-1	INTJ
admet-276	277	204	kg	kg	INTJ
admet-276	277	205	-1	-1	PUNCT
admet-276	277	206	)	)	PUNCT
admet-276	277	207	13.0	13.0	NUM
admet-276	277	208	19.2	19.2	NUM
admet-276	277	209	10.1	10.1	NUM
admet-276	277	210	22.1	22.1	NUM
admet-276	277	211	40.4	40.4	NUM
admet-276	277	212	16.5	16.5	NUM
admet-276	277	213	21.1	21.1	NUM
admet-276	277	214	7.1	7.1	NUM
admet-276	277	215	vss	vss	NOUN
admet-276	277	216	(	(	PUNCT
admet-276	277	217	ml	ml	INTJ
admet-276	277	218	kg	kg	INTJ
admet-276	277	219	-1	-1	PUNCT
admet-276	277	220	)	)	PUNCT
admet-276	277	221	40.5	40.5	NUM
admet-276	277	222	62.9	62.9	NUM
admet-276	277	223	72.9	72.9	NUM
admet-276	277	224	149	149	NUM
admet-276	277	225	44.2	44.2	NUM
admet-276	277	226	60.7	60.7	NUM
admet-276	277	227	35.7	35.7	NUM
admet-276	277	228	41.2	41.2	NUM
admet-276	277	229	*	*	PUNCT
admet-276	277	230	adcetris	adcetris	VERB
admet-276	277	231	/	/	SYM
admet-276	277	232	sgn-35	sgn-35	NUM
admet-276	277	233	mouse	mouse	NOUN
admet-276	277	234	pk	pk	NOUN
admet-276	277	235	data	datum	NOUN
admet-276	277	236	from	from	ADP
admet-276	277	237	ref	ref	NOUN
admet-276	277	238	.	.	PUNCT
admet-276	278	1	[	[	X
admet-276	278	2	47	47	NUM
admet-276	278	3	]	]	PUNCT
admet-276	278	4	,	,	PUNCT
admet-276	278	5	rat	rat	NOUN
admet-276	278	6	and	and	CCONJ
admet-276	278	7	monkey	monkey	PROPN
admet-276	278	8	pk	pk	NOUN
admet-276	278	9	data	datum	NOUN
admet-276	278	10	from	from	ADP
admet-276	278	11	ref	ref	NOUN
admet-276	278	12	.	.	PUNCT
admet-276	279	1	[	[	X
admet-276	279	2	107	107	NUM
admet-276	279	3	]	]	PUNCT
admet-276	279	4	and	and	CCONJ
admet-276	279	5	human	human	PROPN
admet-276	279	6	pk	pk	PROPN
admet-276	279	7	data	datum	NOUN
admet-276	279	8	from	from	ADP
admet-276	279	9	ref	ref	NOUN
admet-276	279	10	.	.	PUNCT
admet-276	280	1	[	[	X
admet-276	280	2	108	108	NUM
admet-276	280	3	]	]	PUNCT
admet-276	280	4	.	.	PUNCT
admet-276	281	1	kadcyla	kadcyla	PROPN
admet-276	281	2	/	/	SYM
admet-276	281	3	tdm1	tdm1	PROPN
admet-276	281	4	mouse	mouse	NOUN
admet-276	281	5	and	and	CCONJ
admet-276	281	6	rat	rat	NOUN
admet-276	281	7	pk	pk	PROPN
admet-276	281	8	data	datum	NOUN
admet-276	281	9	from	from	ADP
admet-276	281	10	ref	ref	NOUN
admet-276	281	11	.	.	PUNCT
admet-276	282	1	[	[	X
admet-276	282	2	109	109	NUM
admet-276	282	3	]	]	PUNCT
admet-276	282	4	,	,	PUNCT
admet-276	282	5	monkey	monkey	NOUN
admet-276	282	6	pk	pk	NOUN
admet-276	282	7	data	datum	NOUN
admet-276	282	8	from	from	ADP
admet-276	282	9	ref	ref	NOUN
admet-276	282	10	.	.	PUNCT
admet-276	283	1	[	[	X
admet-276	283	2	110	110	NUM
admet-276	283	3	]	]	PUNCT
admet-276	283	4	and	and	CCONJ
admet-276	283	5	human	human	PROPN
admet-276	283	6	pk	pk	PROPN
admet-276	283	7	data	datum	NOUN
admet-276	283	8	from	from	ADP
admet-276	283	9	ref	ref	NOUN
admet-276	283	10	.	.	PUNCT
admet-276	284	1	[	[	X
admet-276	284	2	58	58	NUM
admet-276	284	3	]	]	PUNCT
admet-276	284	4	.	.	PUNCT
admet-276	285	1	t1/2	t1/2	PROPN
admet-276	285	2	(	(	PUNCT
admet-276	285	3	calculated	calculate	VERB
admet-276	285	4	)	)	PUNCT
admet-276	285	5	data	datum	NOUN
admet-276	285	6	obtained	obtain	VERB
admet-276	285	7	by	by	ADP
admet-276	285	8	the	the	DET
admet-276	285	9	relationship	relationship	NOUN
admet-276	285	10	between	between	ADP
admet-276	285	11	vd	vd	NOUN
admet-276	285	12	and	and	CCONJ
admet-276	285	13	cl	cl	NOUN
admet-276	285	14	data	datum	NOUN
admet-276	285	15	(	(	PUNCT
admet-276	285	16	t1/2=0.693vd	t1/2=0.693vd	NOUN
admet-276	285	17	/	/	SYM
admet-276	285	18	cl	cl	NOUN
admet-276	285	19	)	)	PUNCT
admet-276	285	20	.	.	PUNCT
admet-276	286	1	despite	despite	SCONJ
admet-276	286	2	considerable	considerable	ADJ
admet-276	286	3	differences	difference	NOUN
admet-276	286	4	between	between	ADP
admet-276	286	5	preclinical	preclinical	ADJ
admet-276	286	6	pk	pk	NOUN
admet-276	286	7	data	datum	NOUN
admet-276	286	8	and	and	CCONJ
admet-276	286	9	unpredictable	unpredictable	ADJ
admet-276	286	10	human	human	ADJ
admet-276	286	11	pk	pk	NOUN
admet-276	286	12	as	as	ADV
admet-276	286	13	well	well	ADV
admet-276	286	14	as	as	ADP
admet-276	286	15	complex	complex	ADJ
admet-276	286	16	pk	pk	PROPN
admet-276	286	17	/	/	SYM
admet-276	286	18	pd	pd	NOUN
admet-276	286	19	implication	implication	NOUN
admet-276	286	20	,	,	PUNCT
admet-276	286	21	saber	saber	NOUN
admet-276	286	22	and	and	CCONJ
admet-276	286	23	leighton	leighton	PROPN
admet-276	286	24	recently	recently	ADV
admet-276	286	25	reported	report	VERB
admet-276	286	26	an	an	DET
admet-276	286	27	fda	fda	PROPN
admet-276	286	28	analysis	analysis	NOUN
admet-276	286	29	of	of	ADP
admet-276	286	30	adcs	adcs	ADV
admet-276	286	31	on	on	ADP
admet-276	286	32	fih	fih	NOUN
admet-276	286	33	dose	dose	NOUN
admet-276	286	34	selection	selection	NOUN
admet-276	286	35	[	[	X
admet-276	286	36	115	115	NUM
admet-276	286	37	]	]	PUNCT
admet-276	286	38	.	.	PUNCT
admet-276	287	1	based	base	VERB
admet-276	287	2	on	on	ADP
admet-276	287	3	an	an	DET
admet-276	287	4	fda	fda	PROPN
admet-276	287	5	oncology	oncology	NOUN
admet-276	287	6	analysis	analysis	NOUN
admet-276	287	7	of	of	ADP
admet-276	287	8	inds	ind	NOUN
admet-276	287	9	for	for	ADP
admet-276	287	10	adcs	adcs	ADV
admet-276	287	11	using	use	VERB
admet-276	287	12	preclinical	preclinical	ADJ
admet-276	287	13	data	datum	NOUN
admet-276	287	14	(	(	PUNCT
admet-276	287	15	plasma	plasma	NOUN
admet-276	287	16	stability	stability	NOUN
admet-276	287	17	,	,	PUNCT
admet-276	287	18	toxicities	toxicity	NOUN
admet-276	287	19	in	in	ADP
admet-276	287	20	animals	animal	NOUN
admet-276	287	21	,	,	PUNCT
admet-276	287	22	and	and	CCONJ
admet-276	287	23	toxicology	toxicology	NOUN
admet-276	287	24	study	study	NOUN
admet-276	287	25	designs	design	NOUN
admet-276	287	26	)	)	PUNCT
admet-276	287	27	,	,	PUNCT
admet-276	287	28	it	it	PRON
admet-276	287	29	was	be	AUX
admet-276	287	30	concluded	conclude	VERB
admet-276	287	31	that	that	SCONJ
admet-276	287	32	adcs	adcs	ADJ
admet-276	287	33	can	can	AUX
admet-276	287	34	share	share	VERB
admet-276	287	35	the	the	DET
admet-276	287	36	same	same	ADJ
admet-276	287	37	small	small	ADJ
admet-276	287	38	molecule	molecule	NOUN
admet-276	287	39	drug	drug	NOUN
admet-276	287	40	concerning	concern	VERB
admet-276	287	41	fih	fih	NOUN
admet-276	287	42	dose	dose	NOUN
admet-276	287	43	selection	selection	NOUN
admet-276	287	44	.	.	PUNCT
admet-276	288	1	more	more	ADV
admet-276	288	2	specifically	specifically	ADV
admet-276	288	3	,	,	PUNCT
admet-276	288	4	selecting	select	VERB
admet-276	288	5	a	a	DET
admet-276	288	6	fih	fih	NOUN
admet-276	288	7	dose	dose	NOUN
admet-276	288	8	such	such	ADJ
admet-276	288	9	as	as	ADP
admet-276	288	10	1/6th	1/6th	NUM
admet-276	288	11	the	the	DET
admet-276	288	12	hong	hong	PROPN
admet-276	288	13	wan	wan	PROPN
admet-276	288	14	admet	admet	PROPN
admet-276	288	15	&	&	CCONJ
admet-276	288	16	dmpk	dmpk	PROPN
admet-276	288	17	4(1	4(1	NOUN
admet-276	288	18	)	)	PUNCT
admet-276	288	19	(	(	PUNCT
admet-276	288	20	2016	2016	NUM
admet-276	288	21	)	)	PUNCT
admet-276	288	22	1	1	NUM
admet-276	288	23	-	-	SYM
admet-276	288	24	22	22	NUM
admet-276	288	25	16	16	NUM
admet-276	288	26	hnstd	hnstd	NOUN
admet-276	288	27	in	in	ADP
admet-276	288	28	cynomolgus	cynomolgus	ADJ
admet-276	288	29	monkeys	monkey	NOUN
admet-276	288	30	or	or	CCONJ
admet-276	288	31	1/10th	1/10th	NUM
admet-276	288	32	the	the	DET
admet-276	288	33	std10	std10	ADV
admet-276	288	34	in	in	ADP
admet-276	288	35	rodents	rodent	NOUN
admet-276	288	36	scaled	scale	VERB
admet-276	288	37	according	accord	VERB
admet-276	288	38	to	to	ADP
admet-276	288	39	bsa	bsa	PROPN
admet-276	288	40	generally	generally	ADV
admet-276	288	41	resulted	result	VERB
admet-276	288	42	in	in	ADP
admet-276	288	43	the	the	DET
admet-276	288	44	acceptable	acceptable	ADJ
admet-276	288	45	balance	balance	NOUN
admet-276	288	46	of	of	ADP
admet-276	288	47	safety	safety	NOUN
admet-276	288	48	and	and	CCONJ
admet-276	288	49	efficient	efficient	ADJ
admet-276	288	50	dose	dose	NOUN
admet-276	288	51	-	-	PUNCT
admet-276	288	52	escalation	escalation	NOUN
admet-276	288	53	in	in	ADP
admet-276	288	54	fih	fih	NOUN
admet-276	288	55	trial	trial	NOUN
admet-276	288	56	.	.	PUNCT
admet-276	289	1	this	this	PRON
admet-276	289	2	certainly	certainly	ADV
admet-276	289	3	provides	provide	VERB
admet-276	289	4	an	an	DET
admet-276	289	5	encouraging	encouraging	ADJ
admet-276	289	6	guideline	guideline	NOUN
admet-276	289	7	to	to	PART
admet-276	289	8	support	support	VERB
admet-276	289	9	the	the	DET
admet-276	289	10	safety	safety	NOUN
admet-276	289	11	evaluation	evaluation	NOUN
admet-276	289	12	of	of	ADP
admet-276	289	13	adcs	adcs	ADJ
admet-276	289	14	and	and	CCONJ
admet-276	289	15	fih	fih	NOUN
admet-276	289	16	dose	dose	NOUN
admet-276	289	17	selection	selection	NOUN
admet-276	289	18	for	for	ADP
admet-276	289	19	clinical	clinical	ADJ
admet-276	289	20	development	development	NOUN
admet-276	289	21	by	by	ADP
admet-276	289	22	similar	similar	ADJ
admet-276	289	23	approach	approach	NOUN
admet-276	289	24	as	as	ADP
admet-276	289	25	small	small	ADJ
admet-276	289	26	molecule	molecule	NOUN
admet-276	289	27	drugs	drug	NOUN
admet-276	289	28	in	in	ADP
admet-276	289	29	this	this	DET
admet-276	289	30	aspect	aspect	NOUN
admet-276	289	31	.	.	PUNCT
admet-276	290	1	6	6	X
admet-276	290	2	.	.	X
admet-276	290	3	concluding	conclude	VERB
admet-276	290	4	remarks	remark	NOUN
admet-276	290	5	biologic	biologic	VERB
admet-276	290	6	large	large	ADJ
admet-276	290	7	molecules	molecule	NOUN
admet-276	290	8	hold	hold	VERB
admet-276	290	9	unique	unique	ADJ
admet-276	290	10	characteristics	characteristic	NOUN
admet-276	290	11	from	from	ADP
admet-276	290	12	small	small	ADJ
admet-276	290	13	chemical	chemical	NOUN
admet-276	290	14	entities	entity	NOUN
admet-276	290	15	.	.	PUNCT
admet-276	291	1	overall	overall	ADV
admet-276	291	2	,	,	PUNCT
admet-276	291	3	the	the	DET
admet-276	291	4	principles	principle	NOUN
admet-276	291	5	of	of	ADP
admet-276	291	6	adme	adme	NOUN
admet-276	291	7	testing	testing	NOUN
admet-276	291	8	for	for	ADP
admet-276	291	9	sms	sm	NOUN
admet-276	291	10	can	can	AUX
admet-276	291	11	be	be	AUX
admet-276	291	12	applied	apply	VERB
admet-276	291	13	to	to	ADP
admet-276	291	14	testing	test	VERB
admet-276	291	15	biologics	biologic	NOUN
admet-276	291	16	such	such	ADJ
admet-276	291	17	as	as	ADP
admet-276	291	18	mabs	mab	NOUN
admet-276	291	19	and	and	CCONJ
admet-276	291	20	adcs	adc	NOUN
admet-276	291	21	.	.	PUNCT
admet-276	292	1	however	however	ADV
admet-276	292	2	,	,	PUNCT
admet-276	292	3	there	there	PRON
admet-276	292	4	are	be	VERB
admet-276	292	5	remarkable	remarkable	ADJ
admet-276	292	6	differences	difference	NOUN
admet-276	292	7	between	between	ADP
admet-276	292	8	sms	sms	PROPN
admet-276	292	9	and	and	CCONJ
admet-276	292	10	lms	lm	NOUN
admet-276	292	11	in	in	ADP
admet-276	292	12	adme	adme	NOUN
admet-276	292	13	assays	assay	NOUN
admet-276	292	14	associated	associate	VERB
admet-276	292	15	with	with	ADP
admet-276	292	16	bioanalytical	bioanalytical	ADJ
admet-276	292	17	strategies	strategy	NOUN
admet-276	292	18	.	.	PUNCT
admet-276	293	1	in	in	ADP
admet-276	293	2	comparison	comparison	NOUN
admet-276	293	3	with	with	ADP
admet-276	293	4	adme	adme	NOUN
admet-276	293	5	testing	testing	NOUN
admet-276	293	6	of	of	ADP
admet-276	293	7	sms	sms	PROPN
admet-276	293	8	,	,	PUNCT
admet-276	293	9	there	there	PRON
admet-276	293	10	are	be	VERB
admet-276	293	11	limited	limit	VERB
admet-276	293	12	in	in	ADP
admet-276	293	13	vitro	vitro	X
admet-276	293	14	models	model	NOUN
admet-276	293	15	for	for	ADP
admet-276	293	16	adme	adme	NOUN
admet-276	293	17	testing	testing	NOUN
admet-276	293	18	of	of	ADP
admet-276	293	19	lms	lm	NOUN
admet-276	293	20	.	.	PUNCT
admet-276	294	1	also	also	ADV
admet-276	294	2	,	,	PUNCT
admet-276	294	3	fewer	few	ADJ
admet-276	294	4	species	specie	NOUN
admet-276	294	5	with	with	ADP
admet-276	294	6	cross	cross	NOUN
admet-276	294	7	-	-	ADJ
admet-276	294	8	reactivity	reactivity	NOUN
admet-276	294	9	can	can	AUX
admet-276	294	10	be	be	AUX
admet-276	294	11	utilized	utilize	VERB
admet-276	294	12	for	for	ADP
admet-276	294	13	in	in	ADP
admet-276	294	14	vivo	vivo	ADJ
admet-276	294	15	pk	pk	NOUN
admet-276	294	16	studies	study	NOUN
admet-276	294	17	as	as	ADV
admet-276	294	18	well	well	ADV
admet-276	294	19	as	as	ADP
admet-276	294	20	safety	safety	NOUN
admet-276	294	21	evaluations	evaluation	NOUN
admet-276	294	22	for	for	ADP
admet-276	294	23	lms	lm	NOUN
admet-276	294	24	.	.	PUNCT
admet-276	295	1	for	for	ADP
admet-276	295	2	initial	initial	ADJ
admet-276	295	3	adc	adc	PROPN
admet-276	295	4	evaluation	evaluation	NOUN
admet-276	295	5	,	,	PUNCT
admet-276	295	6	in	in	ADP
admet-276	295	7	vitro	vitro	X
admet-276	295	8	plasma	plasma	NOUN
admet-276	295	9	stability	stability	NOUN
admet-276	295	10	assay	assay	VERB
admet-276	295	11	combined	combine	VERB
admet-276	295	12	with	with	ADP
admet-276	295	13	monitoring	monitor	VERB
admet-276	295	14	the	the	DET
admet-276	295	15	free	free	ADJ
admet-276	295	16	toxin	toxin	NOUN
admet-276	295	17	released	release	VERB
admet-276	295	18	from	from	ADP
admet-276	295	19	adc	adc	PROPN
admet-276	295	20	in	in	ADV
admet-276	295	21	in	in	ADP
admet-276	295	22	vivo	vivo	ADJ
admet-276	295	23	plasma	plasma	NOUN
admet-276	295	24	can	can	AUX
admet-276	295	25	be	be	AUX
admet-276	295	26	utilized	utilize	VERB
admet-276	295	27	as	as	ADP
admet-276	295	28	a	a	DET
admet-276	295	29	surrogate	surrogate	NOUN
admet-276	295	30	before	before	ADP
admet-276	295	31	conducting	conduct	VERB
admet-276	295	32	complicated	complicated	ADJ
admet-276	295	33	and	and	CCONJ
admet-276	295	34	labintensive	labintensive	ADJ
admet-276	295	35	bioanalytical	bioanalytical	ADJ
admet-276	295	36	method	method	NOUN
admet-276	295	37	development	development	NOUN
admet-276	295	38	for	for	ADP
admet-276	295	39	pk	pk	NOUN
admet-276	295	40	quantification	quantification	NOUN
admet-276	295	41	.	.	PUNCT
admet-276	296	1	from	from	ADP
admet-276	296	2	adme	adme	NOUN
admet-276	296	3	perspective	perspective	NOUN
admet-276	296	4	,	,	PUNCT
admet-276	296	5	the	the	DET
admet-276	296	6	design	design	NOUN
admet-276	296	7	of	of	ADP
admet-276	296	8	novel	novel	ADJ
admet-276	296	9	linkers	linker	NOUN
admet-276	296	10	and	and	CCONJ
admet-276	296	11	the	the	DET
admet-276	296	12	application	application	NOUN
admet-276	296	13	of	of	ADP
admet-276	296	14	new	new	ADJ
admet-276	296	15	conjugation	conjugation	NOUN
admet-276	296	16	technologies	technology	NOUN
admet-276	296	17	for	for	ADP
admet-276	296	18	uniform	uniform	ADJ
admet-276	296	19	dar	dar	PROPN
admet-276	296	20	can	can	AUX
admet-276	296	21	not	not	PART
admet-276	296	22	only	only	ADV
admet-276	296	23	further	far	ADV
admet-276	296	24	improve	improve	VERB
admet-276	296	25	adc	adc	PROPN
admet-276	296	26	stability	stability	NOUN
admet-276	296	27	and	and	CCONJ
admet-276	296	28	consequent	consequent	ADJ
admet-276	296	29	pk	pk	NOUN
admet-276	296	30	profiles	profile	NOUN
admet-276	296	31	as	as	ADV
admet-276	296	32	well	well	ADV
admet-276	296	33	as	as	ADP
admet-276	296	34	tolerability	tolerability	NOUN
admet-276	296	35	in	in	ADP
admet-276	296	36	systemic	systemic	ADJ
admet-276	296	37	circulation	circulation	NOUN
admet-276	296	38	of	of	ADP
admet-276	296	39	adcs	adcs	ADJ
admet-276	296	40	,	,	PUNCT
admet-276	296	41	but	but	CCONJ
admet-276	296	42	also	also	ADV
admet-276	296	43	make	make	VERB
admet-276	296	44	bioanalysis	bioanalysis	NOUN
admet-276	296	45	of	of	ADP
admet-276	296	46	adc	adc	NOUN
admet-276	296	47	relatively	relatively	ADV
admet-276	296	48	easier	easy	ADJ
admet-276	296	49	.	.	PUNCT
admet-276	297	1	general	general	ADJ
admet-276	297	2	adme	adme	PROPN
admet-276	297	3	/	/	SYM
admet-276	297	4	pk	pk	NOUN
admet-276	297	5	testing	testing	NOUN
admet-276	297	6	and	and	CCONJ
admet-276	297	7	nonclinical	nonclinical	ADJ
admet-276	297	8	toxicity	toxicity	NOUN
admet-276	297	9	studies	study	NOUN
admet-276	297	10	should	should	AUX
admet-276	297	11	be	be	AUX
admet-276	297	12	conducted	conduct	VERB
admet-276	297	13	for	for	ADP
admet-276	297	14	both	both	PRON
admet-276	297	15	adc	adc	PROPN
admet-276	297	16	and	and	CCONJ
admet-276	297	17	cytotoxin	cytotoxin	NOUN
admet-276	297	18	as	as	ADP
admet-276	297	19	appropriate	appropriate	ADJ
admet-276	297	20	,	,	PUNCT
admet-276	297	21	as	as	SCONJ
admet-276	297	22	exemplified	exemplify	VERB
admet-276	297	23	in	in	ADP
admet-276	297	24	two	two	NUM
admet-276	297	25	approved	approve	VERB
admet-276	297	26	adc	adc	NOUN
admet-276	297	27	drugs	drug	NOUN
admet-276	297	28	(	(	PUNCT
admet-276	297	29	adcetris	adcetris	NOUN
admet-276	297	30	and	and	CCONJ
admet-276	297	31	kadcyla	kadcyla	NOUN
admet-276	297	32	)	)	PUNCT
admet-276	297	33	.	.	PUNCT
admet-276	298	1	owing	owe	VERB
admet-276	298	2	to	to	ADP
admet-276	298	3	fact	fact	NOUN
admet-276	298	4	that	that	SCONJ
admet-276	298	5	many	many	ADJ
admet-276	298	6	elements	element	NOUN
admet-276	298	7	such	such	ADJ
admet-276	298	8	as	as	ADP
admet-276	298	9	antibody	antibody	NOUN
admet-276	298	10	,	,	PUNCT
admet-276	298	11	free	free	ADJ
admet-276	298	12	toxin	toxin	NOUN
admet-276	298	13	,	,	PUNCT
admet-276	298	14	linker	linker	NOUN
admet-276	298	15	stability	stability	NOUN
admet-276	298	16	as	as	ADV
admet-276	298	17	well	well	ADV
admet-276	298	18	as	as	ADP
admet-276	298	19	product	product	NOUN
admet-276	298	20	attributes	attribute	NOUN
admet-276	298	21	can	can	AUX
admet-276	298	22	be	be	AUX
admet-276	298	23	adc	adc	NOUN
admet-276	298	24	toxicity	toxicity	NOUN
admet-276	298	25	determinants	determinant	NOUN
admet-276	298	26	,	,	PUNCT
admet-276	298	27	adme	adme	NOUN
admet-276	298	28	testing	testing	NOUN
admet-276	298	29	and	and	CCONJ
admet-276	298	30	safety	safety	NOUN
admet-276	298	31	evaluations	evaluation	NOUN
admet-276	298	32	of	of	ADP
admet-276	298	33	adc	adc	PROPN
admet-276	298	34	are	be	AUX
admet-276	298	35	much	much	ADV
admet-276	298	36	more	more	ADV
admet-276	298	37	complex	complex	ADJ
admet-276	298	38	with	with	ADP
admet-276	298	39	significant	significant	ADJ
admet-276	298	40	development	development	NOUN
admet-276	298	41	challenges	challenge	NOUN
admet-276	298	42	,	,	PUNCT
admet-276	298	43	requiring	require	VERB
admet-276	298	44	unique	unique	ADJ
admet-276	298	45	and	and	CCONJ
admet-276	298	46	customized	customize	VERB
admet-276	298	47	nonclinical	nonclinical	ADJ
admet-276	298	48	adme	adme	NOUN
admet-276	298	49	approaches	approach	NOUN
admet-276	298	50	that	that	PRON
admet-276	298	51	differs	differ	VERB
admet-276	298	52	from	from	ADP
admet-276	298	53	classical	classical	ADJ
admet-276	298	54	adme	adme	NOUN
admet-276	298	55	studies	study	NOUN
admet-276	298	56	for	for	ADP
admet-276	298	57	sms	sms	PROPN
admet-276	298	58	.	.	PUNCT
admet-276	299	1	it	it	PRON
admet-276	299	2	appears	appear	VERB
admet-276	299	3	that	that	SCONJ
admet-276	299	4	safety	safety	NOUN
admet-276	299	5	evaluation	evaluation	NOUN
admet-276	299	6	of	of	ADP
admet-276	299	7	key	key	ADJ
admet-276	299	8	drug	drug	NOUN
admet-276	299	9	metabolite	metabolite	NOUN
admet-276	299	10	for	for	ADP
admet-276	299	11	adc	adc	PROPN
admet-276	299	12	drugs	drug	NOUN
admet-276	299	13	may	may	AUX
admet-276	299	14	be	be	AUX
admet-276	299	15	considered	consider	VERB
admet-276	299	16	as	as	ADP
admet-276	299	17	a	a	DET
admet-276	299	18	minor	minor	ADJ
admet-276	299	19	issue	issue	NOUN
admet-276	299	20	as	as	ADV
admet-276	299	21	long	long	ADV
admet-276	299	22	as	as	SCONJ
admet-276	299	23	the	the	DET
admet-276	299	24	released	release	VERB
admet-276	299	25	cytotoxic	cytotoxic	ADJ
admet-276	299	26	concentration	concentration	NOUN
admet-276	299	27	is	be	AUX
admet-276	299	28	far	far	ADV
admet-276	299	29	below	below	ADP
admet-276	299	30	its	its	PRON
admet-276	299	31	mtd	mtd	PROPN
admet-276	299	32	concentration	concentration	NOUN
admet-276	299	33	.	.	PUNCT
admet-276	300	1	however	however	ADV
admet-276	300	2	,	,	PUNCT
admet-276	300	3	the	the	DET
admet-276	300	4	ddi	ddi	PROPN
admet-276	300	5	studies	study	NOUN
admet-276	300	6	on	on	ADP
admet-276	300	7	mabs	mab	NOUN
admet-276	300	8	or	or	CCONJ
admet-276	300	9	adcs	adcs	ADJ
admet-276	300	10	(	(	PUNCT
admet-276	300	11	both	both	CCONJ
admet-276	300	12	adc	adc	PROPN
admet-276	300	13	and	and	CCONJ
admet-276	300	14	cytotoxic	cytotoxic	ADJ
admet-276	300	15	drug	drug	NOUN
admet-276	300	16	)	)	PUNCT
admet-276	300	17	are	be	AUX
admet-276	300	18	strongly	strongly	ADV
admet-276	300	19	recommended	recommend	VERB
admet-276	300	20	by	by	ADP
admet-276	300	21	fda	fda	PROPN
admet-276	300	22	guidance	guidance	NOUN
admet-276	300	23	because	because	SCONJ
admet-276	300	24	of	of	ADP
admet-276	300	25	increased	increase	VERB
admet-276	300	26	use	use	NOUN
admet-276	300	27	of	of	ADP
admet-276	300	28	biotherapeutics	biotherapeutic	NOUN
admet-276	300	29	and	and	CCONJ
admet-276	300	30	clear	clear	ADJ
admet-276	300	31	evidence	evidence	NOUN
admet-276	300	32	of	of	ADP
admet-276	300	33	proteindrug	proteindrug	NOUN
admet-276	300	34	interactions	interaction	NOUN
admet-276	300	35	observed	observe	VERB
admet-276	300	36	in	in	ADP
admet-276	300	37	clinic	clinic	NOUN
admet-276	300	38	.	.	PUNCT
admet-276	301	1	relevant	relevant	ADJ
admet-276	301	2	tools	tool	NOUN
admet-276	301	3	need	need	VERB
admet-276	301	4	to	to	PART
admet-276	301	5	be	be	AUX
admet-276	301	6	developed	develop	VERB
admet-276	301	7	for	for	ADP
admet-276	301	8	early	early	ADJ
admet-276	301	9	ddi	ddi	ADJ
admet-276	301	10	assessment	assessment	NOUN
admet-276	301	11	of	of	ADP
admet-276	301	12	mabs	mab	NOUN
admet-276	301	13	or	or	CCONJ
admet-276	301	14	adcs	adc	VERB
admet-276	301	15	with	with	ADP
admet-276	301	16	small	small	ADJ
admet-276	301	17	molecules	molecule	NOUN
admet-276	301	18	and	and	CCONJ
admet-276	301	19	other	other	ADJ
admet-276	301	20	biologics	biologic	NOUN
admet-276	301	21	for	for	ADP
admet-276	301	22	predicting	predict	VERB
admet-276	301	23	clinical	clinical	ADJ
admet-276	301	24	risk	risk	NOUN
admet-276	301	25	.	.	PUNCT
admet-276	302	1	additionally	additionally	ADV
admet-276	302	2	,	,	PUNCT
admet-276	302	3	it	it	PRON
admet-276	302	4	is	be	AUX
admet-276	302	5	anticipated	anticipate	VERB
admet-276	302	6	that	that	SCONJ
admet-276	302	7	new	new	ADJ
admet-276	302	8	methods	method	NOUN
admet-276	302	9	are	be	AUX
admet-276	302	10	likely	likely	ADJ
admet-276	302	11	to	to	PART
admet-276	302	12	be	be	AUX
admet-276	302	13	developed	develop	VERB
admet-276	302	14	for	for	ADP
admet-276	302	15	a	a	DET
admet-276	302	16	much	much	ADV
admet-276	302	17	better	well	ADJ
admet-276	302	18	understanding	understanding	NOUN
admet-276	302	19	of	of	ADP
admet-276	302	20	the	the	DET
admet-276	302	21	immunotoxic	immunotoxic	ADJ
admet-276	302	22	potential	potential	NOUN
admet-276	302	23	from	from	ADP
admet-276	302	24	preclinical	preclinical	ADJ
admet-276	302	25	observations	observation	NOUN
admet-276	302	26	to	to	ADP
admet-276	302	27	clinic	clinic	NOUN
admet-276	302	28	relevance	relevance	NOUN
admet-276	302	29	.	.	PUNCT
admet-276	303	1	pk	pk	NOUN
admet-276	303	2	of	of	ADP
admet-276	303	3	lms	lm	NOUN
admet-276	303	4	is	be	AUX
admet-276	303	5	often	often	ADV
admet-276	303	6	pd	pd	ADJ
admet-276	303	7	-	-	ADJ
admet-276	303	8	dependent	dependent	ADJ
admet-276	303	9	and	and	CCONJ
admet-276	303	10	it	it	PRON
admet-276	303	11	might	might	AUX
admet-276	303	12	have	have	VERB
admet-276	303	13	a	a	DET
admet-276	303	14	dose	dose	ADJ
admet-276	303	15	proportional	proportional	ADJ
admet-276	303	16	pk	pk	NOUN
admet-276	303	17	owing	owe	VERB
admet-276	303	18	to	to	ADP
admet-276	303	19	no	no	DET
admet-276	303	20	specific	specific	ADJ
admet-276	303	21	binding	binding	NOUN
admet-276	303	22	/	/	SYM
admet-276	303	23	no	no	DET
admet-276	303	24	cross	cross	NOUN
admet-276	303	25	-	-	NOUN
admet-276	303	26	reactivity	reactivity	NOUN
admet-276	303	27	or	or	CCONJ
admet-276	303	28	otherwise	otherwise	ADV
admet-276	303	29	non	non	ADJ
admet-276	303	30	-	-	ADJ
admet-276	303	31	linear	linear	ADJ
admet-276	303	32	pk	pk	NOUN
admet-276	303	33	due	due	ADP
admet-276	303	34	to	to	ADP
admet-276	303	35	specific	specific	ADJ
admet-276	303	36	binding	binding	NOUN
admet-276	303	37	/	/	SYM
admet-276	303	38	cross	cross	NOUN
admet-276	303	39	-	-	NOUN
admet-276	303	40	reactivity	reactivity	NOUN
admet-276	303	41	.	.	PUNCT
admet-276	304	1	currently	currently	ADV
admet-276	304	2	,	,	PUNCT
admet-276	304	3	the	the	DET
admet-276	304	4	prediction	prediction	NOUN
admet-276	304	5	of	of	ADP
admet-276	304	6	human	human	ADJ
admet-276	304	7	pk	pk	NOUN
admet-276	304	8	and	and	CCONJ
admet-276	304	9	translation	translation	NOUN
admet-276	304	10	of	of	ADP
admet-276	304	11	preclinical	preclinical	ADJ
admet-276	304	12	pk	pk	PROPN
admet-276	304	13	/	/	SYM
admet-276	304	14	pd	pd	NOUN
admet-276	304	15	models	model	NOUN
admet-276	304	16	to	to	ADP
admet-276	304	17	clinic	clinic	NOUN
admet-276	304	18	are	be	AUX
admet-276	304	19	challenging	challenge	VERB
admet-276	304	20	especially	especially	ADV
admet-276	304	21	for	for	ADP
admet-276	304	22	adcs	adcs	NOUN
admet-276	304	23	due	due	ADJ
admet-276	304	24	to	to	ADP
admet-276	304	25	limited	limited	ADJ
admet-276	304	26	species	specie	NOUN
admet-276	304	27	with	with	ADP
admet-276	304	28	cross	cross	NOUN
admet-276	304	29	-	-	NOUN
admet-276	304	30	reactivity	reactivity	NOUN
admet-276	304	31	as	as	ADV
admet-276	304	32	well	well	ADV
admet-276	304	33	as	as	ADP
admet-276	304	34	complex	complex	ADJ
admet-276	304	35	tmdd	tmdd	ADJ
admet-276	304	36	and	and	CCONJ
admet-276	304	37	cyp	cyp	ADJ
admet-276	304	38	enzymes	enzyme	NOUN
admet-276	304	39	based	base	VERB
admet-276	304	40	metabolism	metabolism	NOUN
admet-276	304	41	pathways	pathway	NOUN
admet-276	304	42	.	.	PUNCT
admet-276	305	1	in	in	ADP
admet-276	305	2	addition	addition	NOUN
admet-276	305	3	,	,	PUNCT
admet-276	305	4	it	it	PRON
admet-276	305	5	requires	require	VERB
admet-276	305	6	simultaneous	simultaneous	ADJ
admet-276	305	7	quantitative	quantitative	ADJ
admet-276	305	8	understanding	understanding	NOUN
admet-276	305	9	about	about	ADP
admet-276	305	10	the	the	DET
admet-276	305	11	pk	pk	PROPN
admet-276	305	12	/	/	SYM
admet-276	305	13	pd	pd	NOUN
admet-276	305	14	properties	property	NOUN
admet-276	305	15	of	of	ADP
admet-276	305	16	three	three	NUM
admet-276	305	17	different	different	ADJ
admet-276	305	18	molecular	molecular	ADJ
admet-276	305	19	species	specie	NOUN
admet-276	305	20	,	,	PUNCT
admet-276	305	21	i.e.	i.e.	X
admet-276	305	22	,	,	PUNCT
admet-276	305	23	the	the	DET
admet-276	305	24	monoclonal	monoclonal	NOUN
admet-276	305	25	antibody	antibody	NOUN
admet-276	305	26	,	,	PUNCT
admet-276	305	27	the	the	DET
admet-276	305	28	drug	drug	NOUN
admet-276	305	29	,	,	PUNCT
admet-276	305	30	and	and	CCONJ
admet-276	305	31	the	the	DET
admet-276	305	32	conjugate	conjugate	NOUN
admet-276	305	33	in	in	ADP
admet-276	305	34	both	both	CCONJ
admet-276	305	35	serum	serum	NOUN
admet-276	305	36	and	and	CCONJ
admet-276	305	37	tissues	tissue	NOUN
admet-276	305	38	.	.	PUNCT
admet-276	306	1	further	far	ADV
admet-276	306	2	understanding	understand	VERB
admet-276	306	3	pk	pk	NOUN
admet-276	306	4	prediction	prediction	NOUN
admet-276	306	5	models	model	NOUN
admet-276	306	6	of	of	ADP
admet-276	306	7	lms	lm	NOUN
admet-276	306	8	and	and	CCONJ
admet-276	306	9	refining	refining	NOUN
admet-276	306	10	pk	pk	PROPN
admet-276	306	11	/	/	SYM
admet-276	306	12	pd	pd	PROPN
admet-276	306	13	based	base	VERB
admet-276	306	14	on	on	ADP
admet-276	306	15	m&s	m&s	PROPN
admet-276	306	16	are	be	AUX
admet-276	306	17	needed	need	VERB
admet-276	306	18	for	for	ADP
admet-276	306	19	human	human	ADJ
admet-276	306	20	pk	pk	NOUN
admet-276	306	21	and	and	CCONJ
admet-276	306	22	efficacy	efficacy	NOUN
admet-276	306	23	predictions	prediction	NOUN
admet-276	306	24	and	and	CCONJ
admet-276	306	25	dose	dose	NOUN
admet-276	306	26	optimization	optimization	NOUN
admet-276	306	27	.	.	PUNCT
admet-276	307	1	currently	currently	ADV
admet-276	307	2	,	,	PUNCT
admet-276	307	3	lba	lba	PROPN
admet-276	307	4	-	-	PUNCT
admet-276	307	5	based	base	VERB
admet-276	307	6	elisa	elisa	NOUN
admet-276	307	7	is	be	AUX
admet-276	307	8	primarily	primarily	ADV
admet-276	307	9	preferred	prefer	VERB
admet-276	307	10	method	method	NOUN
admet-276	307	11	for	for	ADP
admet-276	307	12	bioanalysis	bioanalysis	NOUN
admet-276	307	13	of	of	ADP
admet-276	307	14	mabs	mab	NOUN
admet-276	307	15	on	on	ADP
admet-276	307	16	available	available	ADJ
admet-276	307	17	highthroughput	highthroughput	NOUN
admet-276	307	18	formats	format	NOUN
admet-276	307	19	.	.	PUNCT
admet-276	308	1	whilst	whilst	SCONJ
admet-276	308	2	lc	lc	PROPN
admet-276	308	3	-	-	PUNCT
admet-276	308	4	ms	ms	NOUN
admet-276	308	5	/	/	PROPN
admet-276	308	6	ms	ms	PROPN
admet-276	308	7	can	can	AUX
admet-276	308	8	be	be	AUX
admet-276	308	9	utilized	utilize	VERB
admet-276	308	10	as	as	ADP
admet-276	308	11	an	an	DET
admet-276	308	12	alternative	alternative	ADJ
admet-276	308	13	technology	technology	NOUN
admet-276	308	14	of	of	ADP
admet-276	308	15	unique	unique	ADJ
admet-276	308	16	advantages	advantage	NOUN
admet-276	308	17	for	for	ADP
admet-276	308	18	simulations	simulation	NOUN
admet-276	308	19	quantification	quantification	NOUN
admet-276	308	20	of	of	ADP
admet-276	308	21	co	co	ADJ
admet-276	308	22	-	-	ADJ
admet-276	308	23	administrated	administrate	VERB
admet-276	308	24	mabs	mab	NOUN
admet-276	308	25	or	or	CCONJ
admet-276	308	26	in	in	ADP
admet-276	308	27	the	the	DET
admet-276	308	28	case	case	NOUN
admet-276	308	29	of	of	ADP
admet-276	308	30	low	low	ADJ
admet-276	308	31	recovery	recovery	NOUN
admet-276	308	32	observed	observe	VERB
admet-276	308	33	due	due	ADJ
admet-276	308	34	to	to	ADP
admet-276	308	35	matrix	matrix	NOUN
admet-276	308	36	interference	interference	NOUN
admet-276	308	37	with	with	ADP
admet-276	308	38	elisa	elisa	NOUN
admet-276	308	39	method	method	NOUN
admet-276	308	40	.	.	PUNCT
admet-276	309	1	although	although	SCONJ
admet-276	309	2	the	the	DET
admet-276	309	3	routine	routine	ADJ
admet-276	309	4	usage	usage	NOUN
admet-276	309	5	of	of	ADP
admet-276	309	6	lc	lc	NOUN
admet-276	309	7	-	-	PUNCT
admet-276	309	8	ms	ms	PROPN
admet-276	309	9	is	be	AUX
admet-276	309	10	mainly	mainly	ADV
admet-276	309	11	hampered	hamper	VERB
admet-276	309	12	by	by	ADP
admet-276	309	13	the	the	DET
admet-276	309	14	relatively	relatively	ADJ
admet-276	309	15	time	time	NOUN
admet-276	309	16	-	-	PUNCT
admet-276	309	17	consuming	consume	VERB
admet-276	309	18	method	method	NOUN
admet-276	309	19	development	development	NOUN
admet-276	309	20	due	due	ADP
admet-276	309	21	to	to	ADP
admet-276	309	22	complex	complex	ADJ
admet-276	309	23	sample	sample	NOUN
admet-276	309	24	preparations	preparation	NOUN
admet-276	309	25	,	,	PUNCT
admet-276	309	26	the	the	DET
admet-276	309	27	availability	availability	NOUN
admet-276	309	28	of	of	ADP
admet-276	309	29	isotopically	isotopically	ADV
admet-276	309	30	labeled	label	VERB
admet-276	309	31	proteins	protein	NOUN
admet-276	309	32	as	as	ADP
admet-276	309	33	iss	iss	PROPN
admet-276	309	34	,	,	PUNCT
admet-276	309	35	immunocapture	immunocapture	NOUN
admet-276	309	36	and	and	CCONJ
admet-276	309	37	enzyme	enzyme	NOUN
admet-276	309	38	digestion	digestion	NOUN
admet-276	309	39	of	of	ADP
admet-276	309	40	lms	lm	NOUN
admet-276	309	41	as	as	ADV
admet-276	309	42	well	well	ADV
admet-276	309	43	as	as	ADP
admet-276	309	44	limited	limited	ADJ
admet-276	309	45	sensitivity	sensitivity	NOUN
admet-276	309	46	as	as	ADP
admet-276	309	47	admet	admet	PROPN
admet-276	309	48	&	&	CCONJ
admet-276	309	49	dmpk	dmpk	PROPN
admet-276	309	50	4(1	4(1	NOUN
admet-276	309	51	)	)	PUNCT
admet-276	309	52	(	(	PUNCT
admet-276	309	53	2016	2016	NUM
admet-276	309	54	)	)	PUNCT
admet-276	309	55	1	1	NUM
admet-276	309	56	-	-	SYM
admet-276	309	57	22	22	NUM
admet-276	309	58	adme	adme	NOUN
admet-276	309	59	testing	testing	NOUN
admet-276	309	60	of	of	ADP
admet-276	309	61	large	large	ADJ
admet-276	309	62	biologics	biologic	NOUN
admet-276	309	63	doi	doi	NOUN
admet-276	309	64	:	:	PUNCT
admet-276	309	65	10.5599	10.5599	NUM
admet-276	309	66	/	/	SYM
admet-276	309	67	admet.4.1.276	admet.4.1.276	NUM
admet-276	309	68	17	17	NUM
admet-276	309	69	compared	compare	VERB
admet-276	309	70	to	to	ADP
admet-276	309	71	a	a	DET
admet-276	309	72	typical	typical	ADJ
admet-276	309	73	bla	bla	NOUN
admet-276	309	74	,	,	PUNCT
admet-276	309	75	the	the	DET
admet-276	309	76	highly	highly	ADV
admet-276	309	77	selective	selective	ADJ
admet-276	309	78	lc	lc	NOUN
admet-276	309	79	-	-	PUNCT
admet-276	309	80	ms	ms	PROPN
admet-276	309	81	has	have	AUX
admet-276	309	82	been	be	AUX
admet-276	309	83	emerging	emerge	VERB
admet-276	309	84	as	as	ADP
admet-276	309	85	a	a	DET
admet-276	309	86	viable	viable	ADJ
admet-276	309	87	alternative	alternative	NOUN
admet-276	309	88	for	for	ADP
admet-276	309	89	qualitative	qualitative	ADJ
admet-276	309	90	and	and	CCONJ
admet-276	309	91	quantitative	quantitative	ADJ
admet-276	309	92	applications	application	NOUN
admet-276	309	93	of	of	ADP
admet-276	309	94	lms	lm	NOUN
admet-276	309	95	,	,	PUNCT
admet-276	309	96	which	which	PRON
admet-276	309	97	can	can	AUX
admet-276	309	98	achieve	achieve	VERB
admet-276	309	99	comparable	comparable	ADJ
admet-276	309	100	detection	detection	NOUN
admet-276	309	101	sensitivity	sensitivity	NOUN
admet-276	309	102	with	with	ADP
admet-276	309	103	elisa	elisa	NOUN
admet-276	309	104	for	for	ADP
admet-276	309	105	pk	pk	NOUN
admet-276	309	106	quantification	quantification	NOUN
admet-276	309	107	of	of	ADP
admet-276	309	108	mabs	mab	NOUN
admet-276	309	109	as	as	SCONJ
admet-276	309	110	demonstrated	demonstrate	VERB
admet-276	309	111	in	in	ADP
admet-276	309	112	a	a	DET
admet-276	309	113	number	number	NOUN
admet-276	309	114	of	of	ADP
admet-276	309	115	recent	recent	ADJ
admet-276	309	116	applications	application	NOUN
admet-276	309	117	.	.	PUNCT
admet-276	310	1	several	several	ADJ
admet-276	310	2	multiple	multiple	ADJ
admet-276	310	3	approaches	approach	NOUN
admet-276	310	4	have	have	AUX
admet-276	310	5	proposed	propose	VERB
admet-276	310	6	to	to	PART
admet-276	310	7	mitigate	mitigate	VERB
admet-276	310	8	interference	interference	NOUN
admet-276	310	9	issues	issue	NOUN
admet-276	310	10	in	in	ADP
admet-276	310	11	lba	lba	PROPN
admet-276	310	12	,	,	PUNCT
admet-276	310	13	including	include	VERB
admet-276	310	14	the	the	DET
admet-276	310	15	use	use	NOUN
admet-276	310	16	of	of	ADP
admet-276	310	17	lc	lc	NOUN
admet-276	310	18	-	-	PUNCT
admet-276	310	19	ms	ms	NOUN
admet-276	310	20	for	for	ADP
admet-276	310	21	bioanalysis	bioanalysis	NOUN
admet-276	310	22	of	of	ADP
admet-276	310	23	mabs	mab	NOUN
admet-276	310	24	.	.	PUNCT
admet-276	311	1	however	however	ADV
admet-276	311	2	,	,	PUNCT
admet-276	311	3	it	it	PRON
admet-276	311	4	is	be	AUX
admet-276	311	5	desirable	desirable	ADJ
admet-276	311	6	to	to	PART
admet-276	311	7	deploy	deploy	VERB
admet-276	311	8	only	only	ADV
admet-276	311	9	one	one	NUM
admet-276	311	10	assay	assay	NOUN
admet-276	311	11	,	,	PUNCT
admet-276	311	12	rather	rather	ADV
admet-276	311	13	than	than	ADP
admet-276	311	14	multiple	multiple	ADJ
admet-276	311	15	assays	assay	NOUN
admet-276	311	16	,	,	PUNCT
admet-276	311	17	especially	especially	ADV
admet-276	311	18	in	in	ADP
admet-276	311	19	later	later	ADJ
admet-276	311	20	stages	stage	NOUN
admet-276	311	21	of	of	ADP
admet-276	311	22	clinical	clinical	ADJ
admet-276	311	23	development	development	NOUN
admet-276	311	24	.	.	PUNCT
admet-276	312	1	due	due	ADP
admet-276	312	2	to	to	ADP
admet-276	312	3	the	the	DET
admet-276	312	4	heterogeneous	heterogeneous	ADJ
admet-276	312	5	nature	nature	NOUN
admet-276	312	6	of	of	ADP
admet-276	312	7	adcs	adcs	ADJ
admet-276	312	8	and	and	CCONJ
admet-276	312	9	potential	potential	ADJ
admet-276	312	10	biotransformation	biotransformation	NOUN
admet-276	312	11	,	,	PUNCT
admet-276	312	12	the	the	DET
admet-276	312	13	hybrid	hybrid	ADJ
admet-276	312	14	technologies	technology	NOUN
admet-276	312	15	of	of	ADP
admet-276	312	16	best	good	ADJ
admet-276	312	17	lba	lba	NOUN
admet-276	312	18	and	and	CCONJ
admet-276	312	19	lc	lc	PROPN
admet-276	312	20	-	-	PUNCT
admet-276	312	21	ms	ms	PROPN
admet-276	312	22	/	/	SYM
admet-276	312	23	ms	ms	PROPN
admet-276	312	24	are	be	AUX
admet-276	312	25	imperative	imperative	ADJ
admet-276	312	26	for	for	ADP
admet-276	312	27	molecular	molecular	ADJ
admet-276	312	28	characterization	characterization	NOUN
admet-276	312	29	,	,	PUNCT
admet-276	312	30	pk	pk	NOUN
admet-276	312	31	/	/	SYM
admet-276	312	32	tk	tk	PROPN
admet-276	312	33	bioanalysis	bioanalysis	NOUN
admet-276	312	34	including	include	VERB
admet-276	312	35	total	total	ADJ
admet-276	312	36	antibody	antibody	NOUN
admet-276	312	37	,	,	PUNCT
admet-276	312	38	total	total	ADJ
admet-276	312	39	adc	adc	NOUN
admet-276	312	40	,	,	PUNCT
admet-276	312	41	antibody	antibody	NOUN
admet-276	312	42	-	-	PUNCT
admet-276	312	43	conjugated	conjugate	VERB
admet-276	312	44	payload	payload	NOUN
admet-276	312	45	and	and	CCONJ
admet-276	312	46	unconjugated	unconjugated	ADJ
admet-276	312	47	payload	payload	NOUN
admet-276	312	48	and	and	CCONJ
admet-276	312	49	immunogenicity	immunogenicity	NOUN
admet-276	312	50	evaluation	evaluation	NOUN
admet-276	312	51	as	as	ADV
admet-276	312	52	well	well	ADV
admet-276	312	53	as	as	ADP
admet-276	312	54	biotransformation	biotransformation	NOUN
admet-276	312	55	and	and	CCONJ
admet-276	312	56	safety	safety	NOUN
admet-276	312	57	assessments	assessment	NOUN
admet-276	312	58	of	of	ADP
admet-276	312	59	adcs	adcs	ADJ
admet-276	312	60	.	.	PUNCT
admet-276	313	1	acknowledgements	acknowledgement	NOUN
admet-276	313	2	author	author	NOUN
admet-276	313	3	would	would	AUX
admet-276	313	4	like	like	VERB
admet-276	313	5	to	to	PART
admet-276	313	6	thank	thank	VERB
admet-276	313	7	his	his	PRON
admet-276	313	8	colleagues	colleague	NOUN
admet-276	313	9	xiaoyan	xiaoyan	PROPN
admet-276	313	10	zhu	zhu	PROPN
admet-276	313	11	,	,	PUNCT
admet-276	313	12	zhendong	zhendong	PROPN
admet-276	313	13	xue	xue	PROPN
admet-276	313	14	,	,	PUNCT
admet-276	313	15	jun	jun	PROPN
admet-276	313	16	feng	feng	PROPN
admet-276	313	17	,	,	PUNCT
admet-276	313	18	kaijie	kaijie	VERB
admet-276	313	19	he	he	PRON
admet-276	313	20	and	and	CCONJ
admet-276	313	21	yuchang	yuchang	PROPN
admet-276	313	22	mao	mao	PROPN
admet-276	313	23	for	for	ADP
admet-276	313	24	helping	help	VERB
admet-276	313	25	with	with	ADP
admet-276	313	26	some	some	DET
admet-276	313	27	references	reference	NOUN
admet-276	313	28	,	,	PUNCT
admet-276	313	29	especially	especially	ADV
admet-276	313	30	dr	dr	PROPN
admet-276	313	31	.	.	PROPN
admet-276	313	32	weikang	weikang	PROPN
admet-276	313	33	tao	tao	PROPN
admet-276	313	34	for	for	ADP
admet-276	313	35	his	his	PRON
admet-276	313	36	valuable	valuable	ADJ
admet-276	313	37	comments	comment	NOUN
admet-276	313	38	and	and	CCONJ
admet-276	313	39	critical	critical	ADJ
admet-276	313	40	review	review	NOUN
admet-276	313	41	of	of	ADP
admet-276	313	42	this	this	DET
admet-276	313	43	manuscript	manuscript	NOUN
admet-276	313	44	,	,	PUNCT
admet-276	313	45	and	and	CCONJ
admet-276	313	46	dr	dr	PROPN
admet-276	313	47	.	.	PROPN
admet-276	313	48	kin	kin	PROPN
admet-276	313	49	tam	tam	PROPN
admet-276	313	50	for	for	ADP
admet-276	313	51	final	final	ADJ
admet-276	313	52	proof	proof	NOUN
admet-276	313	53	-	-	PUNCT
admet-276	313	54	reading	reading	NOUN
admet-276	313	55	of	of	ADP
admet-276	313	56	this	this	DET
admet-276	313	57	manuscript	manuscript	NOUN
admet-276	313	58	.	.	PUNCT
admet-276	314	1	declaration	declaration	NOUN
admet-276	314	2	of	of	ADP
admet-276	314	3	interest	interest	NOUN
admet-276	314	4	this	this	DET
admet-276	314	5	article	article	NOUN
admet-276	314	6	solely	solely	ADV
admet-276	314	7	reflects	reflect	VERB
admet-276	314	8	author	author	NOUN
admet-276	314	9	’s	’s	PART
admet-276	314	10	personal	personal	ADJ
admet-276	314	11	opinions	opinion	NOUN
admet-276	314	12	.	.	PUNCT
admet-276	315	1	the	the	DET
admet-276	315	2	author	author	NOUN
admet-276	315	3	declares	declare	VERB
admet-276	315	4	no	no	DET
admet-276	315	5	competing	compete	VERB
admet-276	315	6	conflicts	conflict	NOUN
admet-276	315	7	of	of	ADP
admet-276	315	8	interest	interest	NOUN
admet-276	315	9	and	and	CCONJ
admet-276	315	10	receives	receive	VERB
admet-276	315	11	no	no	DET
admet-276	315	12	financial	financial	ADJ
admet-276	315	13	support	support	NOUN
admet-276	315	14	from	from	ADP
admet-276	315	15	any	any	DET
admet-276	315	16	affiliations	affiliation	NOUN
admet-276	315	17	in	in	ADP
admet-276	315	18	preparing	prepare	VERB
admet-276	315	19	this	this	DET
admet-276	315	20	manuscript	manuscript	NOUN
admet-276	315	21	.	.	PUNCT
admet-276	316	1	references	reference	NOUN
admet-276	316	2	[	[	X
admet-276	316	3	1	1	NUM
admet-276	316	4	]	]	PUNCT
admet-276	316	5	a.	a.	NOUN
admet-276	316	6	beck	beck	PROPN
admet-276	316	7	,	,	PUNCT
admet-276	316	8	j.m	j.m	PROPN
admet-276	316	9	.	.	PROPN
admet-276	316	10	reichert	reichert	PROPN
admet-276	316	11	.	.	PUNCT
admet-276	317	1	mabs	mabs	PROPN
admet-276	317	2	6	6	NUM
admet-276	317	3	(	(	PUNCT
admet-276	317	4	2014	2014	NUM
admet-276	317	5	)	)	PUNCT
admet-276	317	6	15	15	NUM
admet-276	317	7	-	-	SYM
admet-276	317	8	17	17	NUM
admet-276	317	9	.	.	PUNCT
admet-276	318	1	[	[	X
admet-276	318	2	2	2	X
admet-276	318	3	]	]	X
admet-276	318	4	j.w	j.w	PROPN
admet-276	318	5	.	.	PROPN
admet-276	318	6	lee	lee	PROPN
admet-276	318	7	.	.	PROPN
admet-276	319	1	bioanalysis	bioanalysis	PROPN
admet-276	319	2	5	5	NUM
admet-276	319	3	(	(	PUNCT
admet-276	319	4	2013	2013	NUM
admet-276	319	5	)	)	PUNCT
admet-276	319	6	2003	2003	NUM
admet-276	319	7	-	-	SYM
admet-276	319	8	2014	2014	NUM
admet-276	319	9	.	.	PUNCT
admet-276	320	1	[	[	X
admet-276	320	2	3	3	X
admet-276	320	3	]	]	X
admet-276	320	4	h.l	h.l	PROPN
admet-276	320	5	.	.	PROPN
admet-276	320	6	perez	perez	PROPN
admet-276	320	7	,	,	PUNCT
admet-276	320	8	p.m.	p.m.	NOUN
admet-276	320	9	cardarelli	cardarelli	PROPN
admet-276	320	10	,	,	PUNCT
admet-276	320	11	s.	s.	PROPN
admet-276	320	12	deshpande	deshpande	PROPN
admet-276	320	13	,	,	PUNCT
admet-276	320	14	s.	s.	PROPN
admet-276	320	15	gangwar	gangwar	PROPN
admet-276	320	16	,	,	PUNCT
admet-276	320	17	g.m	g.m	PROPN
admet-276	320	18	.	.	PROPN
admet-276	320	19	schroeder	schroeder	PROPN
admet-276	320	20	,	,	PUNCT
admet-276	320	21	g.d	g.d	PROPN
admet-276	320	22	.	.	PROPN
admet-276	320	23	vite	vite	PROPN
admet-276	320	24	,	,	PUNCT
admet-276	320	25	r.m	r.m	PROPN
admet-276	320	26	.	.	PROPN
admet-276	320	27	borzilleri	borzilleri	PROPN
admet-276	320	28	.	.	PUNCT
admet-276	321	1	drug	drug	NOUN
admet-276	321	2	discov	discov	NOUN
admet-276	321	3	.	.	PUNCT
admet-276	322	1	today	today	NOUN
admet-276	322	2	19	19	NUM
admet-276	322	3	(	(	PUNCT
admet-276	322	4	2014	2014	NUM
admet-276	322	5	)	)	PUNCT
admet-276	322	6	869	869	NUM
admet-276	322	7	-	-	SYM
admet-276	322	8	881	881	NUM
admet-276	322	9	.	.	PUNCT
admet-276	323	1	[	[	X
admet-276	323	2	4	4	NUM
admet-276	323	3	]	]	X
admet-276	323	4	j.m	j.m	PROPN
admet-276	323	5	.	.	PROPN
admet-276	323	6	reichert	reichert	PROPN
admet-276	323	7	.	.	PUNCT
admet-276	323	8	mabs	mabs	PROPN
admet-276	323	9	7	7	NUM
admet-276	323	10	(	(	PUNCT
admet-276	323	11	2015	2015	NUM
admet-276	323	12	)	)	PUNCT
admet-276	323	13	1	1	NUM
admet-276	323	14	-	-	SYM
admet-276	323	15	8	8	NUM
admet-276	323	16	.	.	PUNCT
admet-276	324	1	[	[	X
admet-276	324	2	5	5	X
admet-276	324	3	]	]	PUNCT
admet-276	324	4	t.	t.	NOUN
admet-276	324	5	prueksaritanont	prueksaritanont	NOUN
admet-276	324	6	,	,	PUNCT
admet-276	324	7	c.	c.	PROPN
admet-276	324	8	tang	tang	PROPN
admet-276	324	9	.	.	PUNCT
admet-276	325	1	aaps	aaps	PROPN
admet-276	326	1	j	j	PROPN
admet-276	326	2	14	14	NUM
admet-276	326	3	(	(	PUNCT
admet-276	326	4	2012	2012	NUM
admet-276	326	5	)	)	PUNCT
admet-276	326	6	410	410	NUM
admet-276	326	7	-	-	SYM
admet-276	326	8	419	419	NUM
admet-276	326	9	.	.	PUNCT
admet-276	327	1	[	[	X
admet-276	327	2	6	6	NUM
admet-276	327	3	]	]	PUNCT
admet-276	327	4	k.	k.	NOUN
admet-276	327	5	thudium	thudium	PROPN
admet-276	327	6	,	,	PUNCT
admet-276	327	7	s.	s.	PROPN
admet-276	327	8	bilić	bilić	PROPN
admet-276	327	9	,	,	PUNCT
admet-276	327	10	d.	d.	PROPN
admet-276	327	11	leipold	leipold	PROPN
admet-276	327	12	,	,	PUNCT
admet-276	327	13	w.	w.	PROPN
admet-276	327	14	mallet	mallet	NOUN
admet-276	327	15	,	,	PUNCT
admet-276	327	16	s.	s.	PROPN
admet-276	327	17	kaur	kaur	PROPN
admet-276	327	18	,	,	PUNCT
admet-276	327	19	b.	b.	PROPN
admet-276	327	20	meibohm	meibohm	PROPN
admet-276	327	21	,	,	PUNCT
admet-276	327	22	h.	h.	PROPN
admet-276	327	23	erickson	erickson	PROPN
admet-276	327	24	,	,	PUNCT
admet-276	327	25	j.	j.	PROPN
admet-276	327	26	tibbitts	tibbitts	PROPN
admet-276	327	27	,	,	PUNCT
admet-276	327	28	h.	h.	PROPN
admet-276	327	29	zhao	zhao	PROPN
admet-276	327	30	,	,	PUNCT
admet-276	327	31	m.	m.	NOUN
admet-276	327	32	gupta	gupta	PROPN
admet-276	327	33	.	.	PUNCT
admet-276	327	34	mabs	mab	NOUN
admet-276	327	35	5	5	NUM
admet-276	327	36	(	(	PUNCT
admet-276	327	37	2013	2013	NUM
admet-276	327	38	)	)	PUNCT
admet-276	327	39	5	5	NUM
admet-276	327	40	-	-	SYM
admet-276	327	41	12	12	NUM
admet-276	327	42	.	.	PUNCT
admet-276	328	1	[	[	X
admet-276	328	2	7	7	NUM
admet-276	328	3	]	]	PUNCT
admet-276	328	4	a.	a.	NOUN
admet-276	328	5	mullard	mullard	PROPN
admet-276	328	6	.	.	PUNCT
admet-276	329	1	nat	nat	PROPN
admet-276	329	2	.	.	PUNCT
admet-276	330	1	rev	rev	PROPN
admet-276	330	2	.	.	PROPN
admet-276	330	3	drug	drug	NOUN
admet-276	330	4	discov	discov	NOUN
admet-276	330	5	.	.	PUNCT
admet-276	331	1	12	12	NUM
admet-276	331	2	(	(	PUNCT
admet-276	331	3	2013	2013	NUM
admet-276	331	4	)	)	PUNCT
admet-276	331	5	329	329	NUM
admet-276	331	6	-	-	SYM
admet-276	331	7	332	332	NUM
admet-276	331	8	.	.	PUNCT
admet-276	332	1	[	[	X
admet-276	332	2	8	8	NUM
admet-276	332	3	]	]	X
admet-276	332	4	j.a	j.a	PROPN
admet-276	332	5	.	.	PROPN
admet-276	332	6	cavagnaro	cavagnaro	PROPN
admet-276	332	7	.	.	PUNCT
admet-276	333	1	nat	nat	PROPN
admet-276	333	2	.	.	PUNCT
admet-276	334	1	rev	rev	PROPN
admet-276	334	2	.	.	PROPN
admet-276	334	3	drug	drug	NOUN
admet-276	334	4	discov	discov	NOUN
admet-276	334	5	.	.	PUNCT
admet-276	335	1	1	1	NUM
admet-276	335	2	(	(	PUNCT
admet-276	335	3	2002	2002	NUM
admet-276	335	4	)	)	PUNCT
admet-276	335	5	469	469	NUM
admet-276	335	6	-	-	SYM
admet-276	335	7	475	475	NUM
admet-276	335	8	.	.	PUNCT
admet-276	336	1	[	[	X
admet-276	336	2	9	9	NUM
admet-276	336	3	]	]	X
admet-276	336	4	t.h	t.h	PROPN
admet-276	336	5	.	.	PROPN
admet-276	336	6	han	han	PROPN
admet-276	336	7	,	,	PUNCT
admet-276	336	8	b.	b.	PROPN
admet-276	336	9	zhao	zhao	PROPN
admet-276	336	10	.	.	PUNCT
admet-276	337	1	drug	drug	NOUN
admet-276	337	2	metab	metab	NOUN
admet-276	337	3	.	.	PUNCT
admet-276	338	1	dispos	dispos	PROPN
admet-276	338	2	.	.	PUNCT
admet-276	339	1	42	42	NUM
admet-276	339	2	(	(	PUNCT
admet-276	339	3	2014	2014	NUM
admet-276	339	4	)	)	PUNCT
admet-276	339	5	1914	1914	NUM
admet-276	339	6	-	-	SYM
admet-276	339	7	1920	1920	NUM
admet-276	339	8	.	.	PUNCT
admet-276	340	1	[	[	X
admet-276	340	2	10	10	NUM
admet-276	340	3	]	]	X
admet-276	340	4	s.	s.	PROPN
admet-276	340	5	shi	shi	PROPN
admet-276	340	6	.	.	PUNCT
admet-276	341	1	curr	curr	PROPN
admet-276	341	2	.	.	PUNCT
admet-276	341	3	drug	drug	PROPN
admet-276	341	4	metab	metab	NOUN
admet-276	341	5	.	.	PUNCT
admet-276	342	1	15	15	NUM
admet-276	342	2	(	(	PUNCT
admet-276	342	3	2014	2014	NUM
admet-276	342	4	)	)	PUNCT
admet-276	342	5	271	271	NUM
admet-276	342	6	-	-	SYM
admet-276	342	7	290	290	NUM
admet-276	342	8	.	.	PUNCT
admet-276	343	1	[	[	X
admet-276	343	2	11	11	NUM
admet-276	343	3	]	]	X
admet-276	343	4	e.	e.	PROPN
admet-276	343	5	ezan	ezan	PROPN
admet-276	343	6	,	,	PUNCT
admet-276	343	7	f.	f.	PROPN
admet-276	343	8	becher	becher	PROPN
admet-276	343	9	,	,	PUNCT
admet-276	343	10	f.	f.	PROPN
admet-276	343	11	fenaille	fenaille	PROPN
admet-276	343	12	.	.	PUNCT
admet-276	344	1	expert	expert	NOUN
admet-276	344	2	opin	opin	NOUN
admet-276	344	3	.	.	PUNCT
admet-276	345	1	drug	drug	NOUN
admet-276	345	2	metab	metab	NOUN
admet-276	345	3	.	.	PUNCT
admet-276	346	1	toxicol	toxicol	PROPN
admet-276	346	2	.	.	PUNCT
admet-276	347	1	10	10	NUM
admet-276	347	2	(	(	PUNCT
admet-276	347	3	2014	2014	NUM
admet-276	347	4	)	)	PUNCT
admet-276	347	5	1079	1079	NUM
admet-276	347	6	-	-	SYM
admet-276	347	7	1091	1091	NUM
admet-276	347	8	.	.	PUNCT
admet-276	348	1	[	[	X
admet-276	348	2	12	12	NUM
admet-276	348	3	]	]	PUNCT
admet-276	348	4	h.	h.	PROPN
admet-276	348	5	wan	wan	PROPN
admet-276	348	6	.	.	PROPN
admet-276	348	7	admet	admet	PROPN
admet-276	348	8	&	&	CCONJ
admet-276	348	9	dmpk	dmpk	PROPN
admet-276	348	10	1	1	NUM
admet-276	348	11	(	(	PUNCT
admet-276	348	12	2013	2013	NUM
admet-276	348	13	)	)	PUNCT
admet-276	348	14	19	19	NUM
admet-276	348	15	-	-	SYM
admet-276	348	16	28	28	NUM
admet-276	348	17	.	.	PUNCT
admet-276	349	1	[	[	X
admet-276	349	2	13	13	NUM
admet-276	349	3	]	]	PUNCT
admet-276	349	4	t.	t.	PROPN
admet-276	349	5	tuntland	tuntland	PROPN
admet-276	349	6	,	,	PUNCT
admet-276	349	7	b.	b.	PROPN
admet-276	349	8	ethell	ethell	PROPN
admet-276	349	9	,	,	PUNCT
admet-276	349	10	t.	t.	PROPN
admet-276	349	11	kosaka	kosaka	PROPN
admet-276	349	12	,	,	PUNCT
admet-276	349	13	f.	f.	PROPN
admet-276	349	14	blasco	blasco	PROPN
admet-276	349	15	,	,	PUNCT
admet-276	349	16	r.x	r.x	PROPN
admet-276	349	17	.	.	PROPN
admet-276	349	18	zang	zang	PROPN
admet-276	349	19	,	,	PUNCT
admet-276	349	20	m.	m.	NOUN
admet-276	349	21	jain	jain	PROPN
admet-276	349	22	,	,	PUNCT
admet-276	349	23	t.	t.	PROPN
admet-276	349	24	gould	gould	PROPN
admet-276	349	25	,	,	PUNCT
admet-276	349	26	k.	k.	PROPN
admet-276	349	27	hoffmaster	hoffmaster	PROPN
admet-276	349	28	.	.	PUNCT
admet-276	350	1	front	front	ADJ
admet-276	350	2	.	.	PUNCT
admet-276	351	1	pharmacol	pharmacol	NOUN
admet-276	351	2	.	.	PROPN
admet-276	352	1	5	5	NUM
admet-276	352	2	(	(	PUNCT
admet-276	352	3	2014	2014	NUM
admet-276	352	4	)	)	PUNCT
admet-276	352	5	174	174	NUM
admet-276	352	6	.	.	PUNCT
admet-276	353	1	[	[	X
admet-276	353	2	14	14	NUM
admet-276	353	3	]	]	PUNCT
admet-276	353	4	b.	b.	PROPN
admet-276	353	5	feng	feng	PROPN
admet-276	353	6	,	,	PUNCT
admet-276	353	7	m.v	m.v	PROPN
admet-276	353	8	.	.	PROPN
admet-276	353	9	varma	varma	PROPN
admet-276	353	10	,	,	PUNCT
admet-276	353	11	c.	c.	PROPN
admet-276	353	12	costales	costale	NOUN
admet-276	353	13	,	,	PUNCT
admet-276	353	14	h.	h.	PROPN
admet-276	353	15	zhang	zhang	PROPN
admet-276	353	16	,	,	PUNCT
admet-276	353	17	l.	l.	PROPN
admet-276	353	18	tremaine	tremaine	PROPN
admet-276	353	19	.	.	PUNCT
admet-276	354	1	expert	expert	NOUN
admet-276	354	2	opin	opin	NOUN
admet-276	354	3	.	.	PUNCT
admet-276	355	1	drug	drug	NOUN
admet-276	355	2	discov	discov	NOUN
admet-276	355	3	.	.	PUNCT
admet-276	356	1	9	9	NUM
admet-276	356	2	(	(	PUNCT
admet-276	356	3	2014	2014	NUM
admet-276	356	4	)	)	PUNCT
admet-276	356	5	873	873	NUM
admet-276	356	6	-	-	NUM
admet-276	356	7	890	890	NUM
admet-276	356	8	.	.	PUNCT
admet-276	357	1	[	[	X
admet-276	357	2	15	15	NUM
admet-276	357	3	]	]	X
admet-276	357	4	v.	v.	PROPN
admet-276	357	5	ahuja	ahuja	PROPN
admet-276	357	6	,	,	PUNCT
admet-276	357	7	s.	s.	PROPN
admet-276	357	8	sharma	sharma	PROPN
admet-276	357	9	.	.	PUNCT
admet-276	358	1	j.	j.	PROPN
admet-276	358	2	appl	appl	PROPN
admet-276	358	3	.	.	PUNCT
admet-276	359	1	toxicol	toxicol	PROPN
admet-276	359	2	.	.	PUNCT
admet-276	360	1	34	34	NUM
admet-276	360	2	(	(	PUNCT
admet-276	360	3	2014	2014	NUM
admet-276	360	4	)	)	PUNCT
admet-276	360	5	576	576	NUM
admet-276	360	6	-	-	SYM
admet-276	360	7	594	594	NUM
admet-276	360	8	.	.	PUNCT
admet-276	361	1	[	[	X
admet-276	361	2	16	16	NUM
admet-276	361	3	]	]	PUNCT
admet-276	361	4	m.	m.	NOUN
admet-276	361	5	meng	meng	PROPN
admet-276	361	6	,	,	PUNCT
admet-276	361	7	l.	l.	PROPN
admet-276	361	8	wang	wang	PROPN
admet-276	361	9	,	,	PUNCT
admet-276	361	10	t.	t.	PROPN
admet-276	361	11	voelker	voelker	NOUN
admet-276	361	12	,	,	PUNCT
admet-276	361	13	s.	s.	PROPN
admet-276	361	14	reuschel	reuschel	PROPN
admet-276	361	15	,	,	PUNCT
admet-276	361	16	k.c	k.c	PROPN
admet-276	361	17	.	.	PROPN
admet-276	361	18	van	van	PROPN
admet-276	361	19	horne	horne	PROPN
admet-276	361	20	,	,	PUNCT
admet-276	361	21	p.	p.	PROPN
admet-276	361	22	bennett	bennett	PROPN
admet-276	361	23	.	.	PUNCT
admet-276	362	1	bioanalysis	bioanalysis	NOUN
admet-276	362	2	5	5	NUM
admet-276	362	3	(	(	PUNCT
admet-276	362	4	2013	2013	NUM
admet-276	362	5	)	)	PUNCT
admet-276	362	6	91	91	NUM
admet-276	362	7	-	-	SYM
admet-276	362	8	115	115	NUM
admet-276	362	9	.	.	PUNCT
admet-276	363	1	[	[	X
admet-276	363	2	17	17	NUM
admet-276	363	3	]	]	X
admet-276	363	4	l.	l.	PROPN
admet-276	363	5	li	li	PROPN
admet-276	363	6	,	,	PUNCT
admet-276	363	7	d.	d.	PROPN
admet-276	363	8	tian	tian	PROPN
admet-276	363	9	,	,	PUNCT
admet-276	363	10	f.	f.	PROPN
admet-276	363	11	chen	chen	PROPN
admet-276	363	12	,	,	PUNCT
admet-276	363	13	j.	j.	PROPN
admet-276	363	14	yang	yang	PROPN
admet-276	363	15	,	,	PUNCT
admet-276	363	16	k.	k.	PROPN
admet-276	363	17	yu	yu	PROPN
admet-276	363	18	,	,	PUNCT
admet-276	363	19	y.	y.	PROPN
admet-276	363	20	sun	sun	PROPN
admet-276	363	21	.	.	PUNCT
admet-276	364	1	curr	curr	PROPN
admet-276	364	2	.	.	PUNCT
admet-276	364	3	drug	drug	PROPN
admet-276	364	4	metab	metab	NOUN
admet-276	364	5	.	.	PUNCT
admet-276	365	1	13	13	NUM
admet-276	365	2	(	(	PUNCT
admet-276	365	3	2012	2012	NUM
admet-276	365	4	)	)	PUNCT
admet-276	365	5	1206	1206	NUM
admet-276	365	6	-	-	SYM
admet-276	365	7	1212	1212	NUM
admet-276	365	8	.	.	PUNCT
admet-276	366	1	[	[	X
admet-276	366	2	18	18	NUM
admet-276	366	3	]	]	X
admet-276	366	4	h.	h.	PROPN
admet-276	366	5	wan	wan	PROPN
admet-276	366	6	,	,	PUNCT
admet-276	366	7	a.g	a.g	PROPN
admet-276	366	8	.	.	PROPN
admet-276	366	9	holmen	holmen	PROPN
admet-276	366	10	.	.	PUNCT
admet-276	366	11	comb	comb	PROPN
admet-276	366	12	.	.	PUNCT
admet-276	367	1	chem	chem	NOUN
admet-276	367	2	.	.	PUNCT
admet-276	368	1	high	high	ADJ
admet-276	368	2	throughput	throughput	NOUN
admet-276	368	3	screen	screen	NOUN
admet-276	368	4	.	.	PUNCT
admet-276	369	1	12	12	NUM
admet-276	369	2	(	(	PUNCT
admet-276	369	3	2009	2009	NUM
admet-276	369	4	)	)	PUNCT
admet-276	369	5	315	315	NUM
admet-276	369	6	-	-	SYM
admet-276	369	7	329	329	NUM
admet-276	369	8	.	.	PUNCT
admet-276	370	1	[	[	X
admet-276	370	2	19	19	NUM
admet-276	370	3	]	]	X
admet-276	370	4	h.	h.	PROPN
admet-276	370	5	wan	wan	PROPN
admet-276	370	6	,	,	PUNCT
admet-276	370	7	m.j	m.j	PROPN
admet-276	370	8	.	.	PROPN
admet-276	370	9	rehngren	rehngren	PROPN
admet-276	370	10	.	.	PUNCT
admet-276	371	1	j.	j.	PROPN
admet-276	371	2	chromatogr	chromatogr	PROPN
admet-276	371	3	.	.	PUNCT
admet-276	372	1	a	a	DET
admet-276	372	2	1102	1102	NUM
admet-276	372	3	(	(	PUNCT
admet-276	372	4	2006	2006	NUM
admet-276	372	5	)	)	PUNCT
admet-276	372	6	125	125	NUM
admet-276	372	7	-	-	SYM
admet-276	372	8	134	134	NUM
admet-276	372	9	.	.	PUNCT
admet-276	373	1	[	[	X
admet-276	373	2	20	20	NUM
admet-276	373	3	]	]	PUNCT
admet-276	373	4	h.	h.	PROPN
admet-276	373	5	wan	wan	PROPN
admet-276	373	6	,	,	PUNCT
admet-276	373	7	m.	m.	PROPN
admet-276	373	8	rehngren	rehngren	PROPN
admet-276	373	9	,	,	PUNCT
admet-276	373	10	f.	f.	PROPN
admet-276	373	11	giordanetto	giordanetto	PROPN
admet-276	373	12	,	,	PUNCT
admet-276	373	13	f.	f.	PROPN
admet-276	373	14	bergström	bergström	PROPN
admet-276	373	15	,	,	PUNCT
admet-276	373	16	a.	a.	NOUN
admet-276	373	17	tunek	tunek	PROPN
admet-276	373	18	.	.	PUNCT
admet-276	374	1	j.	j.	PROPN
admet-276	374	2	med	med	PROPN
admet-276	374	3	.	.	PROPN
admet-276	374	4	chem	chem	PROPN
admet-276	374	5	.	.	PUNCT
admet-276	375	1	50	50	NUM
admet-276	375	2	(	(	PUNCT
admet-276	375	3	2007	2007	NUM
admet-276	375	4	)	)	PUNCT
admet-276	375	5	4606	4606	NUM
admet-276	375	6	-	-	SYM
admet-276	375	7	4615	4615	NUM
admet-276	375	8	.	.	PUNCT
admet-276	376	1	hong	hong	PROPN
admet-276	376	2	wan	wan	PROPN
admet-276	376	3	admet	admet	PROPN
admet-276	376	4	&	&	CCONJ
admet-276	376	5	dmpk	dmpk	PROPN
admet-276	376	6	4(1	4(1	NOUN
admet-276	376	7	)	)	PUNCT
admet-276	376	8	(	(	PUNCT
admet-276	376	9	2016	2016	NUM
admet-276	376	10	)	)	PUNCT
admet-276	376	11	1	1	NUM
admet-276	376	12	-	-	SYM
admet-276	376	13	22	22	NUM
admet-276	376	14	18	18	NUM
admet-276	376	15	[	[	X
admet-276	376	16	21	21	NUM
admet-276	376	17	]	]	X
admet-276	376	18	fda	fda	PROPN
admet-276	376	19	guidance	guidance	NOUN
admet-276	376	20	for	for	ADP
admet-276	376	21	industry	industry	NOUN
admet-276	376	22	:	:	PUNCT
admet-276	376	23	safety	safety	NOUN
admet-276	376	24	testing	testing	NOUN
admet-276	376	25	of	of	ADP
admet-276	376	26	drug	drug	NOUN
admet-276	376	27	metabolites	metabolite	NOUN
admet-276	376	28	.	.	PUNCT
admet-276	377	1	(	(	PUNCT
admet-276	377	2	2008	2008	NUM
admet-276	377	3	)	)	PUNCT
admet-276	377	4	available	available	ADJ
admet-276	377	5	from	from	ADP
admet-276	377	6	:	:	PUNCT
admet-276	377	7	http://	http://	PROPN
admet-276	377	8	www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079266.p	www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079266.p	PROPN
admet-276	377	9	df	df	PROPN
admet-276	377	10	(	(	PUNCT
admet-276	377	11	accessed	access	VERB
admet-276	377	12	on	on	ADP
admet-276	377	13	march	march	PROPN
admet-276	377	14	23	23	NUM
admet-276	377	15	,	,	PUNCT
admet-276	377	16	2016	2016	NUM
admet-276	377	17	)	)	PUNCT
admet-276	377	18	.	.	PUNCT
admet-276	378	1	[	[	X
admet-276	378	2	22	22	NUM
admet-276	378	3	]	]	PUNCT
admet-276	378	4	ich	ich	NOUN
admet-276	378	5	guidance	guidance	NOUN
admet-276	378	6	on	on	ADP
admet-276	378	7	nonclinical	nonclinical	ADJ
admet-276	378	8	safety	safety	NOUN
admet-276	378	9	studies	study	NOUN
admet-276	378	10	for	for	ADP
admet-276	378	11	the	the	DET
admet-276	378	12	conduct	conduct	NOUN
admet-276	378	13	of	of	ADP
admet-276	378	14	human	human	ADJ
admet-276	378	15	clinical	clinical	ADJ
admet-276	378	16	trials	trial	NOUN
admet-276	378	17	and	and	CCONJ
admet-276	378	18	marketing	marketing	NOUN
admet-276	378	19	authorization	authorization	NOUN
admet-276	378	20	for	for	ADP
admet-276	378	21	pharmaceuticals	pharmaceutical	NOUN
admet-276	378	22	.	.	PUNCT
admet-276	379	1	(	(	PUNCT
admet-276	379	2	2010	2010	NUM
admet-276	379	3	)	)	PUNCT
admet-276	379	4	available	available	ADJ
admet-276	379	5	from	from	ADP
admet-276	379	6	:	:	PUNCT
admet-276	379	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	PROPN
admet-276	379	8	3246.pdf	3246.pdf	NUM
admet-276	379	9	(	(	PUNCT
admet-276	379	10	accessed	access	VERB
admet-276	379	11	on	on	ADP
admet-276	379	12	march	march	PROPN
admet-276	379	13	23	23	NUM
admet-276	379	14	,	,	PUNCT
admet-276	379	15	2016	2016	NUM
admet-276	379	16	)	)	PUNCT
admet-276	379	17	.	.	PUNCT
admet-276	380	1	[	[	X
admet-276	380	2	23	23	NUM
admet-276	380	3	]	]	X
admet-276	380	4	fda	fda	PROPN
admet-276	380	5	guidance	guidance	NOUN
admet-276	380	6	for	for	ADP
admet-276	380	7	industry	industry	NOUN
admet-276	380	8	:	:	PUNCT
admet-276	380	9	drug	drug	NOUN
admet-276	380	10	interaction	interaction	NOUN
admet-276	380	11	studies	study	NOUN
admet-276	380	12	–	–	PUNCT
admet-276	380	13	study	study	NOUN
admet-276	380	14	design	design	NOUN
admet-276	380	15	,	,	PUNCT
admet-276	380	16	data	datum	NOUN
admet-276	380	17	analysis	analysis	NOUN
admet-276	380	18	,	,	PUNCT
admet-276	380	19	implications	implication	NOUN
admet-276	380	20	for	for	ADP
admet-276	380	21	dosing	dose	VERB
admet-276	380	22	,	,	PUNCT
admet-276	380	23	and	and	CCONJ
admet-276	380	24	labeling	labeling	NOUN
admet-276	380	25	recommendation	recommendation	NOUN
admet-276	380	26	.	.	PUNCT
admet-276	381	1	(	(	PUNCT
admet-276	381	2	2012	2012	NUM
admet-276	381	3	)	)	PUNCT
admet-276	381	4	available	available	ADJ
admet-276	381	5	from	from	ADP
admet-276	381	6	:	:	PUNCT
admet-276	381	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm29	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm29	ADJ
admet-276	381	8	2362.pdf	2362.pdf	NOUN
admet-276	381	9	(	(	PUNCT
admet-276	381	10	accessed	access	VERB
admet-276	381	11	on	on	ADP
admet-276	381	12	march	march	PROPN
admet-276	381	13	23	23	NUM
admet-276	381	14	,	,	PUNCT
admet-276	381	15	2016	2016	NUM
admet-276	381	16	)	)	PUNCT
admet-276	381	17	.	.	PUNCT
admet-276	382	1	[	[	X
admet-276	382	2	24	24	NUM
admet-276	382	3	]	]	PUNCT
admet-276	382	4	k.	k.	PROPN
admet-276	382	5	lin	lin	PROPN
admet-276	382	6	,	,	PUNCT
admet-276	382	7	j.	j.	PROPN
admet-276	382	8	tibbitts	tibbitts	PROPN
admet-276	382	9	.	.	PUNCT
admet-276	383	1	pharm	pharm	PROPN
admet-276	383	2	.	.	PUNCT
admet-276	384	1	res	re	NOUN
admet-276	384	2	.	.	PROPN
admet-276	385	1	29	29	NUM
admet-276	385	2	(	(	PUNCT
admet-276	385	3	2012	2012	NUM
admet-276	385	4	)	)	PUNCT
admet-276	385	5	2354	2354	NUM
admet-276	385	6	-	-	SYM
admet-276	385	7	2366	2366	NUM
admet-276	385	8	.	.	PUNCT
admet-276	386	1	[	[	X
admet-276	386	2	25	25	NUM
admet-276	386	3	]	]	X
admet-276	386	4	s.m	s.m	PROPN
admet-276	386	5	.	.	PROPN
admet-276	386	6	huang	huang	PROPN
admet-276	386	7	,	,	PUNCT
admet-276	386	8	h.	h.	PROPN
admet-276	386	9	zhao	zhao	PROPN
admet-276	386	10	,	,	PUNCT
admet-276	386	11	j.i	j.i	PROPN
admet-276	386	12	.	.	PROPN
admet-276	386	13	lee	lee	PROPN
admet-276	386	14	,	,	PUNCT
admet-276	386	15	k.	k.	PROPN
admet-276	386	16	reynolds	reynolds	PROPN
admet-276	386	17	,	,	PUNCT
admet-276	386	18	l.	l.	PROPN
admet-276	386	19	zhang	zhang	PROPN
admet-276	386	20	,	,	PUNCT
admet-276	386	21	r.	r.	PROPN
admet-276	386	22	temple	temple	PROPN
admet-276	386	23	,	,	PUNCT
admet-276	386	24	l.j	l.j	PROPN
admet-276	386	25	.	.	PROPN
admet-276	386	26	lesko	lesko	PROPN
admet-276	386	27	.	.	PUNCT
admet-276	387	1	clin	clin	PROPN
admet-276	387	2	.	.	PUNCT
admet-276	388	1	pharmacol	pharmacol	PROPN
admet-276	388	2	.	.	PUNCT
admet-276	389	1	ther	ther	PROPN
admet-276	389	2	.	.	PUNCT
admet-276	390	1	87	87	NUM
admet-276	390	2	(	(	PUNCT
admet-276	390	3	2010	2010	NUM
admet-276	390	4	)	)	PUNCT
admet-276	390	5	497	497	NUM
admet-276	390	6	-	-	SYM
admet-276	390	7	503	503	NUM
admet-276	390	8	.	.	PUNCT
admet-276	391	1	[	[	X
admet-276	391	2	26	26	NUM
admet-276	391	3	]	]	X
admet-276	391	4	i.a	i.a	PROPN
admet-276	391	5	.	.	PROPN
admet-276	391	6	kaltashov	kaltashov	PROPN
admet-276	391	7	,	,	PUNCT
admet-276	391	8	c.e	c.e	PROPN
admet-276	391	9	.	.	PROPN
admet-276	391	10	bobst	bobst	PROPN
admet-276	391	11	,	,	PUNCT
admet-276	391	12	r.r	r.r	PROPN
admet-276	391	13	.	.	PROPN
admet-276	391	14	abzalimov	abzalimov	PROPN
admet-276	391	15	,	,	PUNCT
admet-276	391	16	g.	g.	PROPN
admet-276	391	17	wang	wang	PROPN
admet-276	391	18	,	,	PUNCT
admet-276	391	19	b.	b.	PROPN
admet-276	391	20	baykal	baykal	PROPN
admet-276	391	21	,	,	PUNCT
admet-276	391	22	s.	s.	PROPN
admet-276	391	23	wang	wang	PROPN
admet-276	391	24	.	.	PUNCT
admet-276	392	1	biotechnol	biotechnol	PROPN
admet-276	392	2	.	.	PUNCT
admet-276	393	1	adv	adv	PROPN
admet-276	393	2	.	.	PROPN
admet-276	393	3	30	30	NUM
admet-276	393	4	(	(	PUNCT
admet-276	393	5	2012	2012	NUM
admet-276	393	6	)	)	PUNCT
admet-276	393	7	210	210	NUM
admet-276	393	8	-	-	SYM
admet-276	393	9	222	222	NUM
admet-276	393	10	.	.	PUNCT
admet-276	394	1	[	[	X
admet-276	394	2	27	27	NUM
admet-276	394	3	]	]	PUNCT
admet-276	394	4	d.	d.	PROPN
admet-276	394	5	nebija	nebija	PROPN
admet-276	394	6	,	,	PUNCT
admet-276	394	7	h.	h.	PROPN
admet-276	394	8	kopelent	kopelent	PROPN
admet-276	394	9	-	-	PUNCT
admet-276	394	10	frank	frank	PROPN
admet-276	394	11	,	,	PUNCT
admet-276	394	12	e.	e.	PROPN
admet-276	394	13	urban	urban	PROPN
admet-276	394	14	,	,	PUNCT
admet-276	394	15	c.r	c.r	PROPN
admet-276	394	16	.	.	PROPN
admet-276	394	17	noe	noe	PROPN
admet-276	394	18	,	,	PUNCT
admet-276	394	19	b.	b.	PROPN
admet-276	394	20	lachmann	lachmann	PROPN
admet-276	394	21	.	.	PUNCT
admet-276	395	1	j.	j.	PROPN
admet-276	395	2	pharm	pharm	PROPN
admet-276	395	3	.	.	PUNCT
admet-276	395	4	biomed	biome	VERB
admet-276	395	5	.	.	PUNCT
admet-276	396	1	anal	anal	ADJ
admet-276	396	2	.	.	PUNCT
admet-276	397	1	56	56	NUM
admet-276	397	2	(	(	PUNCT
admet-276	397	3	2011	2011	NUM
admet-276	397	4	)	)	PUNCT
admet-276	397	5	684	684	NUM
admet-276	397	6	-	-	SYM
admet-276	397	7	691	691	NUM
admet-276	397	8	.	.	PUNCT
admet-276	398	1	[	[	X
admet-276	398	2	28	28	NUM
admet-276	398	3	]	]	X
admet-276	398	4	j.	j.	PROPN
admet-276	398	5	visser	visser	PROPN
admet-276	398	6	,	,	PUNCT
admet-276	398	7	i.	i.	PROPN
admet-276	398	8	feuerstein	feuerstein	PROPN
admet-276	398	9	,	,	PUNCT
admet-276	398	10	t.	t.	PROPN
admet-276	398	11	stangler	stangler	NOUN
admet-276	398	12	,	,	PUNCT
admet-276	398	13	t.	t.	PROPN
admet-276	398	14	schmiederer	schmiederer	PROPN
admet-276	398	15	,	,	PUNCT
admet-276	398	16	c.	c.	PROPN
admet-276	398	17	fritsch	fritsch	PROPN
admet-276	398	18	,	,	PUNCT
admet-276	398	19	m.	m.	NOUN
admet-276	398	20	schiestl	schiestl	PROPN
admet-276	398	21	.	.	PUNCT
admet-276	399	1	biodrugs	biodrug	NOUN
admet-276	399	2	27	27	NUM
admet-276	399	3	(	(	PUNCT
admet-276	399	4	2013	2013	NUM
admet-276	399	5	)	)	PUNCT
admet-276	399	6	495507	495507	NUM
admet-276	399	7	.	.	PUNCT
admet-276	400	1	[	[	X
admet-276	400	2	29	29	NUM
admet-276	400	3	]	]	X
admet-276	400	4	m.m	m.m	PROPN
admet-276	400	5	.	.	PROPN
admet-276	400	6	sun	sun	PROPN
admet-276	400	7	,	,	PUNCT
admet-276	400	8	k.s	k.s	PROPN
admet-276	400	9	.	.	PROPN
admet-276	400	10	beam	beam	PROPN
admet-276	400	11	,	,	PUNCT
admet-276	400	12	c.g	c.g	PROPN
admet-276	400	13	.	.	PROPN
admet-276	400	14	cerveny	cerveny	PROPN
admet-276	400	15	,	,	PUNCT
admet-276	400	16	k.j	k.j	PROPN
admet-276	400	17	.	.	PUNCT
admet-276	400	18	hamblett	hamblett	PROPN
admet-276	400	19	,	,	PUNCT
admet-276	400	20	r.s	r.s	PROPN
admet-276	400	21	.	.	PROPN
admet-276	400	22	blackmore	blackmore	PROPN
admet-276	400	23	,	,	PUNCT
admet-276	400	24	m.y	m.y	PROPN
admet-276	400	25	.	.	PROPN
admet-276	400	26	torgov	torgov	VERB
admet-276	400	27	,	,	PUNCT
admet-276	400	28	f.g.m	f.g.m	NOUN
admet-276	400	29	.	.	PUNCT
admet-276	401	1	handley	handley	PROPN
admet-276	401	2	,	,	PUNCT
admet-276	401	3	n.c	n.c	PROPN
admet-276	401	4	.	.	PROPN
admet-276	401	5	ihle	ihle	PROPN
admet-276	401	6	,	,	PUNCT
admet-276	401	7	p.d	p.d	PROPN
admet-276	401	8	.	.	PROPN
admet-276	401	9	senter	senter	PROPN
admet-276	401	10	,	,	PUNCT
admet-276	401	11	s.c	s.c	PROPN
admet-276	401	12	.	.	PROPN
admet-276	401	13	alley	alley	PROPN
admet-276	401	14	.	.	PUNCT
admet-276	402	1	bioconjug	bioconjug	NOUN
admet-276	402	2	.	.	PUNCT
admet-276	403	1	chem	chem	NOUN
admet-276	403	2	.	.	PUNCT
admet-276	404	1	16	16	NUM
admet-276	404	2	(	(	PUNCT
admet-276	404	3	2005	2005	NUM
admet-276	404	4	)	)	PUNCT
admet-276	404	5	1282	1282	NUM
admet-276	404	6	-	-	SYM
admet-276	404	7	1290	1290	NUM
admet-276	404	8	.	.	PUNCT
admet-276	405	1	[	[	X
admet-276	405	2	30	30	NUM
admet-276	405	3	]	]	X
admet-276	405	4	r.j	r.j	PROPN
admet-276	405	5	.	.	PROPN
admet-276	405	6	harris	harris	PROPN
admet-276	405	7	,	,	PUNCT
admet-276	405	8	b.	b.	PROPN
admet-276	405	9	kabakoff	kabakoff	PROPN
admet-276	405	10	,	,	PUNCT
admet-276	405	11	f.d	f.d	PROPN
admet-276	405	12	.	.	PROPN
admet-276	405	13	macchi	macchi	PROPN
admet-276	405	14	,	,	PUNCT
admet-276	405	15	f.j	f.j	PROPN
admet-276	405	16	.	.	PROPN
admet-276	405	17	shen	shen	PROPN
admet-276	405	18	,	,	PUNCT
admet-276	405	19	m.	m.	PROPN
admet-276	405	20	kwong	kwong	PROPN
admet-276	405	21	,	,	PUNCT
admet-276	405	22	j.d	j.d	PROPN
admet-276	405	23	.	.	PROPN
admet-276	405	24	andya	andya	PROPN
admet-276	405	25	,	,	PUNCT
admet-276	405	26	s.j	s.j	PROPN
admet-276	405	27	.	.	PROPN
admet-276	405	28	shire	shire	PROPN
admet-276	405	29	,	,	PUNCT
admet-276	405	30	n.	n.	PROPN
admet-276	405	31	bjork	bjork	PROPN
admet-276	405	32	,	,	PUNCT
admet-276	405	33	k.	k.	PROPN
admet-276	405	34	totpal	totpal	PROPN
admet-276	405	35	,	,	PUNCT
admet-276	405	36	a.b	a.b	PROPN
admet-276	405	37	.	.	PROPN
admet-276	405	38	chen	chen	PROPN
admet-276	405	39	.	.	PUNCT
admet-276	406	1	j.	j.	PROPN
admet-276	406	2	chromatogr	chromatogr	PROPN
admet-276	406	3	.	.	PUNCT
admet-276	407	1	b	b	X
admet-276	407	2	biomed	biome	VERB
admet-276	407	3	.	.	PUNCT
admet-276	408	1	sci	sci	PROPN
admet-276	408	2	.	.	PROPN
admet-276	408	3	appl	appl	PROPN
admet-276	408	4	.	.	PUNCT
admet-276	409	1	752	752	NUM
admet-276	409	2	(	(	PUNCT
admet-276	409	3	2001	2001	NUM
admet-276	409	4	)	)	PUNCT
admet-276	409	5	233	233	NUM
admet-276	409	6	-	-	SYM
admet-276	409	7	245	245	NUM
admet-276	409	8	.	.	PUNCT
admet-276	410	1	[	[	X
admet-276	410	2	31	31	NUM
admet-276	410	3	]	]	PUNCT
admet-276	410	4	j.	j.	PROPN
admet-276	410	5	vlasak	vlasak	PROPN
admet-276	410	6	,	,	PUNCT
admet-276	410	7	r.	r.	PROPN
admet-276	410	8	ionescu	ionescu	PROPN
admet-276	410	9	.	.	PUNCT
admet-276	411	1	curr	curr	PROPN
admet-276	411	2	.	.	PUNCT
admet-276	412	1	pharm	pharm	PROPN
admet-276	412	2	.	.	PUNCT
admet-276	413	1	biotechnol	biotechnol	PROPN
admet-276	413	2	.	.	PUNCT
admet-276	414	1	9	9	NUM
admet-276	414	2	(	(	PUNCT
admet-276	414	3	2008	2008	NUM
admet-276	414	4	)	)	PUNCT
admet-276	414	5	468	468	NUM
admet-276	414	6	-	-	SYM
admet-276	414	7	481	481	NUM
admet-276	414	8	.	.	PUNCT
admet-276	415	1	[	[	X
admet-276	415	2	32	32	NUM
admet-276	415	3	]	]	X
admet-276	415	4	s.r	s.r	PROPN
admet-276	415	5	.	.	PROPN
admet-276	415	6	trevino	trevino	PROPN
admet-276	415	7	,	,	PUNCT
admet-276	415	8	j.m	j.m	PROPN
admet-276	415	9	.	.	PROPN
admet-276	415	10	scholtz	scholtz	PROPN
admet-276	415	11	,	,	PUNCT
admet-276	415	12	c.n	c.n	PROPN
admet-276	415	13	.	.	PROPN
admet-276	415	14	pace	pace	NOUN
admet-276	415	15	.	.	PUNCT
admet-276	416	1	j.	j.	PROPN
admet-276	416	2	pharm	pharm	PROPN
admet-276	416	3	.	.	PUNCT
admet-276	417	1	sci	sci	PROPN
admet-276	417	2	.	.	PROPN
admet-276	417	3	97	97	NUM
admet-276	417	4	(	(	PUNCT
admet-276	417	5	2008	2008	NUM
admet-276	417	6	)	)	PUNCT
admet-276	417	7	4155	4155	NUM
admet-276	417	8	-	-	SYM
admet-276	417	9	4166	4166	NUM
admet-276	417	10	.	.	PUNCT
admet-276	418	1	[	[	X
admet-276	418	2	33	33	NUM
admet-276	418	3	]	]	X
admet-276	418	4	t.j	t.j	PROPN
admet-276	418	5	.	.	PROPN
admet-276	418	6	gibson	gibson	PROPN
admet-276	418	7	,	,	PUNCT
admet-276	418	8	k.	k.	PROPN
admet-276	418	9	mccarty	mccarty	PROPN
admet-276	418	10	,	,	PUNCT
admet-276	418	11	i.j	i.j	PROPN
admet-276	418	12	.	.	PROPN
admet-276	418	13	mcfadyen	mcfadyen	PROPN
admet-276	418	14	,	,	PUNCT
admet-276	418	15	e.	e.	PROPN
admet-276	418	16	cash	cash	PROPN
admet-276	418	17	,	,	PUNCT
admet-276	418	18	p.	p.	PROPN
admet-276	418	19	dalmonte	dalmonte	PROPN
admet-276	418	20	,	,	PUNCT
admet-276	418	21	k.d	k.d	PROPN
admet-276	418	22	.	.	PROPN
admet-276	418	23	hinds	hinds	PROPN
admet-276	418	24	,	,	PUNCT
admet-276	418	25	a.a	a.a	PROPN
admet-276	418	26	.	.	PROPN
admet-276	418	27	dinerman	dinerman	PROPN
admet-276	418	28	,	,	PUNCT
admet-276	418	29	j.c	j.c	PROPN
admet-276	418	30	.	.	PROPN
admet-276	418	31	alvarez	alvarez	PROPN
admet-276	418	32	,	,	PUNCT
admet-276	418	33	d.b	d.b	PROPN
admet-276	418	34	.	.	PROPN
admet-276	418	35	volkin	volkin	PROPN
admet-276	418	36	.	.	PUNCT
admet-276	419	1	j.	j.	PROPN
admet-276	419	2	pharm	pharm	PROPN
admet-276	419	3	.	.	PUNCT
admet-276	420	1	sci	sci	PROPN
admet-276	420	2	.	.	PROPN
admet-276	420	3	100	100	NUM
admet-276	420	4	(	(	PUNCT
admet-276	420	5	2011	2011	NUM
admet-276	420	6	)	)	PUNCT
admet-276	420	7	1009	1009	NUM
admet-276	420	8	-	-	SYM
admet-276	420	9	1021	1021	NUM
admet-276	420	10	.	.	PUNCT
admet-276	421	1	[	[	X
admet-276	421	2	34	34	NUM
admet-276	421	3	]	]	X
admet-276	421	4	fda	fda	PROPN
admet-276	421	5	.	.	PUNCT
admet-276	421	6	guidance	guidance	NOUN
admet-276	421	7	for	for	ADP
admet-276	421	8	industry	industry	NOUN
admet-276	421	9	:	:	PUNCT
admet-276	421	10	assay	assay	VERB
admet-276	421	11	development	development	NOUN
admet-276	421	12	for	for	ADP
admet-276	421	13	immunogenicity	immunogenicity	NOUN
admet-276	421	14	testing	testing	NOUN
admet-276	421	15	of	of	ADP
admet-276	421	16	therapeutic	therapeutic	ADJ
admet-276	421	17	proteins	protein	NOUN
admet-276	421	18	.	.	PUNCT
admet-276	422	1	(	(	PUNCT
admet-276	422	2	2009	2009	NUM
admet-276	422	3	)	)	PUNCT
admet-276	422	4	available	available	ADJ
admet-276	422	5	from	from	ADP
admet-276	422	6	:	:	PUNCT
admet-276	422	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm19	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm19	NUM
admet-276	422	8	2750.pdf	2750.pdf	NUM
admet-276	422	9	.	.	PUNCT
admet-276	423	1	(	(	PUNCT
admet-276	423	2	accessed	access	VERB
admet-276	423	3	on	on	ADP
admet-276	423	4	march	march	PROPN
admet-276	423	5	23	23	NUM
admet-276	423	6	,	,	PUNCT
admet-276	423	7	2016	2016	NUM
admet-276	423	8	)	)	PUNCT
admet-276	423	9	.	.	PUNCT
admet-276	424	1	[	[	X
admet-276	424	2	35	35	NUM
admet-276	424	3	]	]	X
admet-276	424	4	fda	fda	PROPN
admet-276	424	5	.	.	PUNCT
admet-276	424	6	guidance	guidance	NOUN
admet-276	424	7	for	for	ADP
admet-276	424	8	industry	industry	NOUN
admet-276	424	9	:	:	PUNCT
admet-276	424	10	immunotoxicology	immunotoxicology	NOUN
admet-276	424	11	evaluation	evaluation	NOUN
admet-276	424	12	of	of	ADP
admet-276	424	13	investigation	investigation	NOUN
admet-276	424	14	new	new	ADJ
admet-276	424	15	drug	drug	NOUN
admet-276	424	16	.	.	PUNCT
admet-276	425	1	(	(	PUNCT
admet-276	425	2	2002	2002	NUM
admet-276	425	3	)	)	PUNCT
admet-276	425	4	available	available	ADJ
admet-276	425	5	from	from	ADP
admet-276	425	6	:	:	PUNCT
admet-276	425	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	ADJ
admet-276	425	8	9239.pdf	9239.pdf	NOUN
admet-276	425	9	.	.	PUNCT
admet-276	426	1	(	(	PUNCT
admet-276	426	2	accessed	access	VERB
admet-276	426	3	on	on	ADP
admet-276	426	4	march	march	PROPN
admet-276	426	5	23	23	NUM
admet-276	426	6	,	,	PUNCT
admet-276	426	7	2016	2016	NUM
admet-276	426	8	)	)	PUNCT
admet-276	426	9	.	.	PUNCT
admet-276	427	1	[	[	X
admet-276	427	2	36	36	NUM
admet-276	427	3	]	]	X
admet-276	427	4	e.d	e.d	PROPN
admet-276	427	5	.	.	PROPN
admet-276	427	6	lobo	lobo	PROPN
admet-276	427	7	,	,	PUNCT
admet-276	427	8	r.j	r.j	PROPN
admet-276	427	9	.	.	PROPN
admet-276	427	10	hansen	hansen	PROPN
admet-276	427	11	,	,	PUNCT
admet-276	427	12	j.p	j.p	PROPN
admet-276	427	13	.	.	PROPN
admet-276	427	14	balthasar	balthasar	PROPN
admet-276	427	15	.	.	PUNCT
admet-276	428	1	j.	j.	PROPN
admet-276	428	2	pharm	pharm	PROPN
admet-276	428	3	.	.	PUNCT
admet-276	429	1	sci	sci	PROPN
admet-276	429	2	.	.	PROPN
admet-276	430	1	93	93	NUM
admet-276	430	2	(	(	PUNCT
admet-276	430	3	2004	2004	NUM
admet-276	430	4	)	)	PUNCT
admet-276	430	5	2645	2645	NUM
admet-276	430	6	-	-	SYM
admet-276	430	7	2668	2668	NUM
admet-276	430	8	.	.	PUNCT
admet-276	431	1	[	[	X
admet-276	431	2	37	37	NUM
admet-276	431	3	]	]	X
admet-276	431	4	j.h	j.h	PROPN
admet-276	431	5	.	.	PROPN
admet-276	431	6	lin	lin	PROPN
admet-276	431	7	.	.	PUNCT
admet-276	432	1	curr	curr	PROPN
admet-276	432	2	.	.	PUNCT
admet-276	432	3	drug	drug	PROPN
admet-276	432	4	metab	metab	NOUN
admet-276	432	5	.	.	PUNCT
admet-276	433	1	10	10	NUM
admet-276	433	2	(	(	PUNCT
admet-276	433	3	2009	2009	NUM
admet-276	433	4	)	)	PUNCT
admet-276	433	5	661	661	NUM
admet-276	433	6	-	-	SYM
admet-276	433	7	691	691	NUM
admet-276	433	8	.	.	PUNCT
admet-276	434	1	[	[	X
admet-276	434	2	38	38	NUM
admet-276	434	3	]	]	X
admet-276	434	4	y.	y.	PROPN
admet-276	434	5	vugmeyster	vugmeyster	PROPN
admet-276	434	6	,	,	PUNCT
admet-276	434	7	x.	x.	PROPN
admet-276	434	8	xu	xu	PROPN
admet-276	434	9	,	,	PUNCT
admet-276	434	10	f.p	f.p	PROPN
admet-276	434	11	.	.	PROPN
admet-276	434	12	theil	theil	PROPN
admet-276	434	13	,	,	PUNCT
admet-276	434	14	l.a	l.a	PROPN
admet-276	434	15	.	.	PROPN
admet-276	434	16	khawli	khawli	PROPN
admet-276	434	17	,	,	PUNCT
admet-276	434	18	m.w	m.w	PROPN
admet-276	434	19	.	.	PROPN
admet-276	434	20	leach	leach	NOUN
admet-276	434	21	.	.	PUNCT
admet-276	435	1	world	world	NOUN
admet-276	435	2	j.	j.	PROPN
admet-276	435	3	biol	biol	PROPN
admet-276	435	4	.	.	PUNCT
admet-276	436	1	chem	chem	NOUN
admet-276	436	2	.	.	PUNCT
admet-276	437	1	3	3	NUM
admet-276	437	2	(	(	PUNCT
admet-276	437	3	2012	2012	NUM
admet-276	437	4	)	)	PUNCT
admet-276	437	5	73	73	NUM
admet-276	437	6	-	-	SYM
admet-276	437	7	92	92	NUM
admet-276	437	8	.	.	PUNCT
admet-276	438	1	[	[	X
admet-276	438	2	39	39	NUM
admet-276	438	3	]	]	PUNCT
admet-276	438	4	r.	r.	PROPN
admet-276	438	5	deng	deng	PROPN
admet-276	438	6	,	,	PUNCT
admet-276	438	7	f.	f.	PROPN
admet-276	438	8	jin	jin	PROPN
admet-276	438	9	,	,	PUNCT
admet-276	438	10	s.	s.	PROPN
admet-276	438	11	prabhu	prabhu	PROPN
admet-276	438	12	,	,	PUNCT
admet-276	438	13	s.	s.	PROPN
admet-276	438	14	iyer	iyer	PROPN
admet-276	438	15	.	.	PUNCT
admet-276	439	1	expert	expert	NOUN
admet-276	439	2	opin	opin	NOUN
admet-276	439	3	.	.	PUNCT
admet-276	440	1	drug	drug	NOUN
admet-276	440	2	metab	metab	NOUN
admet-276	440	3	.	.	PUNCT
admet-276	441	1	toxicol	toxicol	PROPN
admet-276	441	2	.	.	PROPN
admet-276	441	3	8	8	NUM
admet-276	441	4	(	(	PUNCT
admet-276	441	5	2012	2012	NUM
admet-276	441	6	)	)	PUNCT
admet-276	441	7	141	141	NUM
admet-276	441	8	-	-	SYM
admet-276	441	9	160	160	NUM
admet-276	441	10	.	.	PUNCT
admet-276	442	1	[	[	X
admet-276	442	2	40	40	NUM
admet-276	442	3	]	]	X
admet-276	442	4	j.d	j.d	PROPN
admet-276	442	5	.	.	PROPN
admet-276	442	6	gomez	gomez	PROPN
admet-276	442	7	-	-	PUNCT
admet-276	442	8	mantilla	mantilla	NOUN
admet-276	442	9	,	,	PUNCT
admet-276	442	10	i.f	i.f	PROPN
admet-276	442	11	.	.	PROPN
admet-276	442	12	troconiz	troconiz	PROPN
admet-276	442	13	,	,	PUNCT
admet-276	442	14	z.	z.	PROPN
admet-276	442	15	parra	parra	PROPN
admet-276	442	16	-	-	PUNCT
admet-276	442	17	guillen	guillen	PROPN
admet-276	442	18	,	,	PUNCT
admet-276	442	19	m.j	m.j	PROPN
admet-276	442	20	.	.	PROPN
admet-276	442	21	garrido	garrido	PROPN
admet-276	442	22	.	.	PUNCT
admet-276	443	1	j.	j.	PROPN
admet-276	443	2	pharmacokinet	pharmacokinet	PROPN
admet-276	443	3	.	.	PUNCT
admet-276	444	1	pharmacodyn	pharmacodyn	ADV
admet-276	444	2	.	.	PUNCT
admet-276	445	1	41	41	NUM
admet-276	445	2	(	(	PUNCT
admet-276	445	3	2014	2014	NUM
admet-276	445	4	)	)	PUNCT
admet-276	445	5	523	523	NUM
admet-276	445	6	-	-	SYM
admet-276	445	7	536	536	NUM
admet-276	445	8	.	.	PUNCT
admet-276	446	1	[	[	X
admet-276	446	2	41	41	NUM
admet-276	446	3	]	]	X
admet-276	446	4	s.a	s.a	PROPN
admet-276	446	5	.	.	PROPN
admet-276	446	6	roberts	roberts	PROPN
admet-276	446	7	,	,	PUNCT
admet-276	446	8	p.a	p.a	PROPN
admet-276	446	9	.	.	PROPN
admet-276	446	10	andrews	andrews	PROPN
admet-276	446	11	,	,	PUNCT
admet-276	446	12	d.	d.	PROPN
admet-276	446	13	blanset	blanset	VERB
admet-276	447	1	d	d	PROPN
admet-276	447	2	,	,	PUNCT
admet-276	447	3	k.m	k.m	PROPN
admet-276	447	4	.	.	PROPN
admet-276	447	5	flagella	flagella	PROPN
admet-276	447	6	,	,	PUNCT
admet-276	447	7	b.	b.	PROPN
admet-276	447	8	gorovits	gorovits	PROPN
admet-276	447	9	,	,	PUNCT
admet-276	447	10	c.m	c.m	PROPN
admet-276	447	11	.	.	PROPN
admet-276	447	12	lynch	lynch	PROPN
admet-276	447	13	,	,	PUNCT
admet-276	447	14	p.l	p.l	PROPN
admet-276	447	15	.	.	PROPN
admet-276	447	16	martin	martin	PROPN
admet-276	447	17	,	,	PUNCT
admet-276	447	18	k.	k.	PROPN
admet-276	447	19	kramer	kramer	PROPN
admet-276	447	20	-	-	PUNCT
admet-276	447	21	stickland	stickland	PROPN
admet-276	447	22	,	,	PUNCT
admet-276	447	23	s.	s.	PROPN
admet-276	447	24	thibault	thibault	PROPN
admet-276	447	25	,	,	PUNCT
admet-276	447	26	g.	g.	PROPN
admet-276	447	27	warner	warner	PROPN
admet-276	447	28	.	.	PUNCT
admet-276	448	1	regul	regul	NOUN
admet-276	448	2	.	.	PUNCT
admet-276	449	1	toxicol	toxicol	PROPN
admet-276	449	2	.	.	PUNCT
admet-276	450	1	pharmacol	pharmacol	PROPN
admet-276	450	2	.	.	PROPN
admet-276	451	1	67	67	NUM
admet-276	451	2	(	(	PUNCT
admet-276	451	3	2013	2013	NUM
admet-276	451	4	)	)	PUNCT
admet-276	451	5	382	382	NUM
admet-276	451	6	-	-	SYM
admet-276	451	7	391	391	NUM
admet-276	451	8	.	.	PUNCT
admet-276	452	1	[	[	X
admet-276	452	2	42	42	NUM
admet-276	452	3	]	]	PUNCT
admet-276	452	4	p.	p.	NOUN
admet-276	452	5	chamberlain	chamberlain	PROPN
admet-276	452	6	.	.	PUNCT
admet-276	453	1	bioanalysis	bioanalysis	NOUN
admet-276	453	2	5	5	NUM
admet-276	453	3	(	(	PUNCT
admet-276	453	4	2013	2013	NUM
admet-276	453	5	)	)	PUNCT
admet-276	453	6	561	561	NUM
admet-276	453	7	-	-	SYM
admet-276	453	8	574	574	NUM
admet-276	453	9	.	.	PUNCT
admet-276	454	1	[	[	X
admet-276	454	2	43	43	NUM
admet-276	454	3	]	]	X
admet-276	454	4	c.a	c.a	PROPN
admet-276	454	5	.	.	PROPN
admet-276	454	6	boswell	boswell	PROPN
admet-276	454	7	,	,	PUNCT
admet-276	454	8	e.e	e.e	PROPN
admet-276	454	9	.	.	PROPN
admet-276	454	10	mundo	mundo	PROPN
admet-276	454	11	,	,	PUNCT
admet-276	454	12	c.	c.	PROPN
admet-276	454	13	zhang	zhang	PROPN
admet-276	454	14	,	,	PUNCT
admet-276	454	15	d.	d.	PROPN
admet-276	454	16	bumbaca	bumbaca	PROPN
admet-276	454	17	,	,	PUNCT
admet-276	454	18	n.r	n.r	PROPN
admet-276	454	19	.	.	PROPN
admet-276	454	20	valle	valle	PROPN
admet-276	454	21	,	,	PUNCT
admet-276	454	22	k.r	k.r	PROPN
admet-276	454	23	.	.	PROPN
admet-276	454	24	kozak	kozak	PROPN
admet-276	454	25	,	,	PUNCT
admet-276	454	26	a.	a.	PROPN
admet-276	454	27	fourie	fourie	PROPN
admet-276	454	28	,	,	PUNCT
admet-276	454	29	j.	j.	PROPN
admet-276	454	30	chuh	chuh	PROPN
admet-276	454	31	,	,	PUNCT
admet-276	454	32	n.	n.	PROPN
admet-276	454	33	koppada	koppada	PROPN
admet-276	454	34	,	,	PUNCT
admet-276	454	35	o.	o.	PROPN
admet-276	454	36	saad	saad	PROPN
admet-276	454	37	,	,	PUNCT
admet-276	454	38	h.	h.	PROPN
admet-276	454	39	gill	gill	PROPN
admet-276	454	40	,	,	PUNCT
admet-276	454	41	b.q	b.q	PROPN
admet-276	454	42	.	.	PROPN
admet-276	454	43	shen	shen	PROPN
admet-276	454	44	,	,	PUNCT
admet-276	454	45	b.	b.	PROPN
admet-276	454	46	rubinfeld	rubinfeld	PROPN
admet-276	454	47	,	,	PUNCT
admet-276	454	48	j.	j.	PROPN
admet-276	454	49	tibbitts	tibbitts	PROPN
admet-276	454	50	,	,	PUNCT
admet-276	454	51	s.	s.	PROPN
admet-276	454	52	kaur	kaur	PROPN
admet-276	454	53	,	,	PUNCT
admet-276	454	54	f.p	f.p	PROPN
admet-276	454	55	.	.	PROPN
admet-276	454	56	theil	theil	PROPN
admet-276	454	57	,	,	PUNCT
admet-276	454	58	p.j	p.j	PROPN
admet-276	454	59	.	.	PROPN
admet-276	454	60	fielder	fielder	PROPN
admet-276	454	61	,	,	PUNCT
admet-276	454	62	l.a	l.a	PROPN
admet-276	454	63	.	.	PROPN
admet-276	454	64	khawli	khawli	PROPN
admet-276	454	65	,	,	PUNCT
admet-276	454	66	k.	k.	PROPN
admet-276	454	67	lin	lin	PROPN
admet-276	454	68	.	.	PUNCT
admet-276	455	1	bioconjug	bioconjug	NOUN
admet-276	455	2	.	.	PUNCT
admet-276	456	1	chem	chem	NOUN
admet-276	456	2	.	.	PUNCT
admet-276	457	1	22	22	NUM
admet-276	457	2	(	(	PUNCT
admet-276	457	3	2011	2011	NUM
admet-276	457	4	)	)	PUNCT
admet-276	457	5	1994	1994	NUM
admet-276	457	6	-	-	SYM
admet-276	457	7	2004	2004	NUM
admet-276	457	8	.	.	PUNCT
admet-276	458	1	admet	admet	PROPN
admet-276	458	2	&	&	CCONJ
admet-276	458	3	dmpk	dmpk	PROPN
admet-276	458	4	4(1	4(1	NOUN
admet-276	458	5	)	)	PUNCT
admet-276	458	6	(	(	PUNCT
admet-276	458	7	2016	2016	NUM
admet-276	458	8	)	)	PUNCT
admet-276	458	9	1	1	NUM
admet-276	458	10	-	-	SYM
admet-276	458	11	22	22	NUM
admet-276	458	12	adme	adme	NOUN
admet-276	458	13	testing	testing	NOUN
admet-276	458	14	of	of	ADP
admet-276	458	15	large	large	ADJ
admet-276	458	16	biologics	biologic	NOUN
admet-276	458	17	doi	doi	NOUN
admet-276	458	18	:	:	PUNCT
admet-276	458	19	10.5599	10.5599	NUM
admet-276	458	20	/	/	SYM
admet-276	458	21	admet.4.1.276	admet.4.1.276	NUM
admet-276	458	22	19	19	NUM
admet-276	458	23	[	[	SYM
admet-276	458	24	44	44	NUM
admet-276	458	25	]	]	PUNCT
admet-276	458	26	e.	e.	PROPN
admet-276	458	27	chertova	chertova	PROPN
admet-276	458	28	,	,	PUNCT
admet-276	458	29	c.	c.	PROPN
admet-276	458	30	bergamaschi	bergamaschi	PROPN
admet-276	458	31	,	,	PUNCT
admet-276	458	32	o.	o.	PROPN
admet-276	458	33	chertov	chertov	PROPN
admet-276	458	34	,	,	PUNCT
admet-276	458	35	r.	r.	PROPN
admet-276	458	36	sowder	sowder	PROPN
admet-276	458	37	,	,	PUNCT
admet-276	458	38	j.	j.	PROPN
admet-276	458	39	bear	bear	PROPN
admet-276	458	40	,	,	PUNCT
admet-276	458	41	j.d	j.d	PROPN
admet-276	458	42	.	.	PROPN
admet-276	458	43	roser	roser	PROPN
admet-276	458	44	,	,	PUNCT
admet-276	458	45	r.k	r.k	PROPN
admet-276	458	46	.	.	PROPN
admet-276	458	47	beach	beach	PROPN
admet-276	458	48	,	,	PUNCT
admet-276	458	49	j.d	j.d	PROPN
admet-276	458	50	.	.	PROPN
admet-276	458	51	lifson	lifson	PROPN
admet-276	458	52	,	,	PUNCT
admet-276	458	53	b.k	b.k	PROPN
admet-276	458	54	.	.	PROPN
admet-276	458	55	felber	felber	PROPN
admet-276	458	56	,	,	PUNCT
admet-276	458	57	g.n	g.n	PROPN
admet-276	458	58	.	.	PROPN
admet-276	458	59	pavlakis	pavlakis	PROPN
admet-276	458	60	.	.	PUNCT
admet-276	459	1	j.	j.	PROPN
admet-276	459	2	biol	biol	PROPN
admet-276	459	3	.	.	PUNCT
admet-276	460	1	chem	chem	NOUN
admet-276	460	2	.	.	PUNCT
admet-276	461	1	288	288	NUM
admet-276	461	2	(	(	PUNCT
admet-276	461	3	2013	2013	NUM
admet-276	461	4	)	)	PUNCT
admet-276	461	5	18093	18093	NUM
admet-276	461	6	-	-	SYM
admet-276	461	7	18103	18103	NUM
admet-276	461	8	.	.	PUNCT
admet-276	462	1	[	[	X
admet-276	462	2	45	45	NUM
admet-276	462	3	]	]	PUNCT
admet-276	462	4	j.	j.	PROPN
admet-276	462	5	gaudreault	gaudreault	PROPN
admet-276	462	6	,	,	PUNCT
admet-276	462	7	d.	d.	PROPN
admet-276	462	8	fei	fei	PROPN
admet-276	462	9	,	,	PUNCT
admet-276	462	10	j.	j.	PROPN
admet-276	462	11	rusit	rusit	PROPN
admet-276	462	12	,	,	PUNCT
admet-276	462	13	p.	p.	NOUN
admet-276	462	14	suboc	suboc	NOUN
admet-276	462	15	,	,	PUNCT
admet-276	462	16	v.	v.	PROPN
admet-276	462	17	shiu	shiu	AUX
admet-276	462	18	.	.	PUNCT
admet-276	462	19	invest	invest	PROPN
admet-276	462	20	.	.	PUNCT
admet-276	463	1	ophthalmol	ophthalmol	PROPN
admet-276	463	2	.	.	PUNCT
admet-276	464	1	vis	vis	X
admet-276	464	2	.	.	PUNCT
admet-276	465	1	sci	sci	PROPN
admet-276	465	2	.	.	PROPN
admet-276	465	3	46	46	NUM
admet-276	465	4	(	(	PUNCT
admet-276	465	5	2005	2005	NUM
admet-276	465	6	)	)	PUNCT
admet-276	465	7	726	726	NUM
admet-276	465	8	-	-	SYM
admet-276	465	9	733	733	NUM
admet-276	465	10	.	.	PUNCT
admet-276	466	1	[	[	X
admet-276	466	2	46	46	NUM
admet-276	466	3	]	]	PUNCT
admet-276	466	4	s.	s.	PROPN
admet-276	466	5	kaur	kaur	PROPN
admet-276	466	6	,	,	PUNCT
admet-276	466	7	k.	k.	PROPN
admet-276	466	8	xu	xu	PROPN
admet-276	466	9	,	,	PUNCT
admet-276	466	10	o.m	o.m	PROPN
admet-276	466	11	.	.	PROPN
admet-276	466	12	saad	saad	PROPN
admet-276	466	13	,	,	PUNCT
admet-276	466	14	r.c	r.c	PROPN
admet-276	466	15	.	.	PROPN
admet-276	466	16	dere	dere	PROPN
admet-276	466	17	,	,	PUNCT
admet-276	466	18	m.	m.	PROPN
admet-276	466	19	carrasco	carrasco	PROPN
admet-276	466	20	-	-	PUNCT
admet-276	466	21	triguero	triguero	PROPN
admet-276	466	22	.	.	PUNCT
admet-276	467	1	bioanalysis	bioanalysis	NOUN
admet-276	467	2	5	5	NUM
admet-276	467	3	(	(	PUNCT
admet-276	467	4	2013	2013	NUM
admet-276	467	5	)	)	PUNCT
admet-276	467	6	201	201	NUM
admet-276	467	7	-	-	SYM
admet-276	467	8	226	226	NUM
admet-276	467	9	.	.	PUNCT
admet-276	468	1	[	[	X
admet-276	468	2	47	47	NUM
admet-276	468	3	]	]	X
admet-276	468	4	k.j	k.j	PROPN
admet-276	468	5	.	.	PUNCT
admet-276	469	1	hamblett	hamblett	PROPN
admet-276	469	2	,	,	PUNCT
admet-276	469	3	p.d	p.d	PROPN
admet-276	469	4	.	.	PROPN
admet-276	469	5	senter	senter	PROPN
admet-276	469	6	,	,	PUNCT
admet-276	469	7	d.f	d.f	PROPN
admet-276	469	8	.	.	PROPN
admet-276	469	9	chace	chace	PROPN
admet-276	469	10	,	,	PUNCT
admet-276	469	11	m.m.c	m.m.c	PROPN
admet-276	469	12	.	.	PUNCT
admet-276	469	13	sun	sun	PROPN
admet-276	469	14	,	,	PUNCT
admet-276	469	15	j.	j.	PROPN
admet-276	469	16	lenox	lenox	PROPN
admet-276	469	17	,	,	PUNCT
admet-276	469	18	c.g	c.g	PROPN
admet-276	469	19	.	.	PROPN
admet-276	469	20	cerveny	cerveny	PROPN
admet-276	469	21	,	,	PUNCT
admet-276	469	22	k.m	k.m	PROPN
admet-276	469	23	.	.	PROPN
admet-276	469	24	kissler	kissler	PROPN
admet-276	469	25	,	,	PUNCT
admet-276	469	26	s.x	s.x	PROPN
admet-276	469	27	.	.	PROPN
admet-276	469	28	bernhardt	bernhardt	PROPN
admet-276	469	29	,	,	PUNCT
admet-276	469	30	a.k	a.k	PROPN
admet-276	469	31	.	.	PROPN
admet-276	469	32	kopcha	kopcha	PROPN
admet-276	469	33	,	,	PUNCT
admet-276	469	34	r.f	r.f	PROPN
admet-276	469	35	.	.	PROPN
admet-276	469	36	zabinski	zabinski	PROPN
admet-276	469	37	,	,	PUNCT
admet-276	469	38	d.l	d.l	PROPN
admet-276	469	39	.	.	PROPN
admet-276	469	40	meyer	meyer	PROPN
admet-276	469	41	,	,	PUNCT
admet-276	469	42	j.a	j.a	PROPN
admet-276	469	43	.	.	PROPN
admet-276	469	44	francisco	francisco	PROPN
admet-276	469	45	.	.	PUNCT
admet-276	470	1	clin	clin	PROPN
admet-276	470	2	.	.	PUNCT
admet-276	471	1	cancer	cancer	NOUN
admet-276	471	2	res	re	NOUN
admet-276	471	3	.	.	PUNCT
admet-276	472	1	10	10	NUM
admet-276	472	2	(	(	PUNCT
admet-276	472	3	2004	2004	NUM
admet-276	472	4	)	)	PUNCT
admet-276	472	5	70637070	70637070	NUM
admet-276	472	6	.	.	PUNCT
admet-276	473	1	[	[	X
admet-276	473	2	48	48	NUM
admet-276	473	3	]	]	PUNCT
admet-276	473	4	m.	m.	NOUN
admet-276	473	5	dorywalska	dorywalska	NOUN
admet-276	473	6	,	,	PUNCT
admet-276	473	7	p.	p.	NOUN
admet-276	473	8	strop	strop	NOUN
admet-276	473	9	,	,	PUNCT
admet-276	473	10	j.a	j.a	PROPN
admet-276	473	11	.	.	PROPN
admet-276	473	12	melton	melton	PROPN
admet-276	473	13	-	-	PUNCT
admet-276	473	14	witt	witt	PROPN
admet-276	473	15	,	,	PUNCT
admet-276	473	16	a.	a.	PROPN
admet-276	473	17	hasa	hasa	PROPN
admet-276	473	18	-	-	PUNCT
admet-276	473	19	moreno	moreno	PROPN
admet-276	473	20	,	,	PUNCT
admet-276	473	21	s.e	s.e	PROPN
admet-276	473	22	.	.	PROPN
admet-276	473	23	farias	farias	PROPN
admet-276	473	24	,	,	PUNCT
admet-276	473	25	m.g	m.g	PROPN
admet-276	473	26	.	.	PROPN
admet-276	473	27	casas	casas	PROPN
admet-276	473	28	,	,	PUNCT
admet-276	473	29	k.	k.	PROPN
admet-276	473	30	delaria	delaria	PROPN
admet-276	473	31	,	,	PUNCT
admet-276	473	32	v.	v.	ADP
admet-276	473	33	lui	lui	PROPN
admet-276	473	34	,	,	PUNCT
admet-276	473	35	k.	k.	PROPN
admet-276	473	36	poulsen	poulsen	PROPN
admet-276	473	37	,	,	PUNCT
admet-276	473	38	c.	c.	PROPN
admet-276	473	39	loo	loo	PROPN
admet-276	473	40	,	,	PUNCT
admet-276	473	41	s.	s.	PROPN
admet-276	473	42	krimm	krimm	PROPN
admet-276	473	43	,	,	PUNCT
admet-276	473	44	g.	g.	PROPN
admet-276	473	45	bolton	bolton	PROPN
admet-276	473	46	,	,	PUNCT
admet-276	473	47	l.	l.	PROPN
admet-276	473	48	moine	moine	PROPN
admet-276	473	49	,	,	PUNCT
admet-276	473	50	r.	r.	PROPN
admet-276	473	51	dushin	dushin	PROPN
admet-276	473	52	,	,	PUNCT
admet-276	473	53	t.t	t.t	PROPN
admet-276	473	54	.	.	PROPN
admet-276	473	55	tran	tran	PROPN
admet-276	473	56	,	,	PUNCT
admet-276	473	57	s.h	s.h	PROPN
admet-276	473	58	.	.	PROPN
admet-276	473	59	liu	liu	PROPN
admet-276	473	60	,	,	PUNCT
admet-276	473	61	m.	m.	PROPN
admet-276	473	62	rickert	rickert	PROPN
admet-276	473	63	,	,	PUNCT
admet-276	473	64	d.	d.	PROPN
admet-276	473	65	foletti	foletti	PROPN
admet-276	473	66	,	,	PUNCT
admet-276	473	67	d.l	d.l	PROPN
admet-276	473	68	.	.	PROPN
admet-276	473	69	shelton	shelton	PROPN
admet-276	473	70	,	,	PUNCT
admet-276	473	71	j.	j.	PROPN
admet-276	473	72	pons	pons	PROPN
admet-276	473	73	,	,	PUNCT
admet-276	473	74	a.	a.	PROPN
admet-276	473	75	rajpal	rajpal	PROPN
admet-276	473	76	.	.	PUNCT
admet-276	474	1	bioconjug	bioconjug	NOUN
admet-276	474	2	.	.	PUNCT
admet-276	475	1	chem	chem	NOUN
admet-276	475	2	.	.	PUNCT
admet-276	476	1	26	26	NUM
admet-276	476	2	(	(	PUNCT
admet-276	476	3	2015	2015	NUM
admet-276	476	4	)	)	PUNCT
admet-276	476	5	650	650	NUM
admet-276	476	6	-	-	SYM
admet-276	476	7	659	659	NUM
admet-276	476	8	.	.	PUNCT
admet-276	477	1	[	[	X
admet-276	477	2	49	49	NUM
admet-276	477	3	]	]	X
admet-276	477	4	a.g	a.g	PROPN
admet-276	477	5	.	.	PROPN
admet-276	477	6	polson	polson	PROPN
admet-276	477	7	,	,	PUNCT
admet-276	477	8	j.	j.	PROPN
admet-276	477	9	calemine	calemine	PROPN
admet-276	477	10	-	-	PUNCT
admet-276	477	11	fenaux	fenaux	ADJ
admet-276	477	12	,	,	PUNCT
admet-276	477	13	p.	p.	PROPN
admet-276	477	14	chan	chan	PROPN
admet-276	477	15	,	,	PUNCT
admet-276	477	16	w.	w.	PROPN
admet-276	477	17	chang	chang	PROPN
admet-276	477	18	,	,	PUNCT
admet-276	477	19	e.	e.	PROPN
admet-276	477	20	christensen	christensen	PROPN
admet-276	477	21	,	,	PUNCT
admet-276	477	22	s.	s.	PROPN
admet-276	477	23	clark	clark	PROPN
admet-276	477	24	,	,	PUNCT
admet-276	477	25	f.j	f.j	PROPN
admet-276	477	26	.	.	PROPN
admet-276	477	27	de	de	X
admet-276	477	28	sauvage	sauvage	PROPN
admet-276	477	29	,	,	PUNCT
admet-276	477	30	d.	d.	PROPN
admet-276	477	31	eaton	eaton	PROPN
admet-276	477	32	,	,	PUNCT
admet-276	477	33	k.	k.	PROPN
admet-276	477	34	elkins	elkins	PROPN
admet-276	477	35	,	,	PUNCT
admet-276	477	36	j.m	j.m	PROPN
admet-276	477	37	.	.	PROPN
admet-276	477	38	elliott	elliott	PROPN
admet-276	477	39	,	,	PUNCT
admet-276	477	40	g.	g.	PROPN
admet-276	477	41	frantz	frantz	PROPN
admet-276	477	42	,	,	PUNCT
admet-276	477	43	r.n	r.n	PROPN
admet-276	477	44	.	.	PROPN
admet-276	477	45	fuji	fuji	PROPN
admet-276	477	46	,	,	PUNCT
admet-276	477	47	a.	a.	NOUN
admet-276	477	48	gray	gray	PROPN
admet-276	477	49	,	,	PUNCT
admet-276	477	50	k.	k.	PROPN
admet-276	477	51	harden	harden	PROPN
admet-276	477	52	,	,	PUNCT
admet-276	477	53	g.s	g.s	PROPN
admet-276	477	54	.	.	PROPN
admet-276	477	55	ingle	ingle	PROPN
admet-276	477	56	,	,	PUNCT
admet-276	477	57	n.m	n.m	PROPN
admet-276	477	58	.	.	PROPN
admet-276	477	59	kljavin	kljavin	PROPN
admet-276	477	60	,	,	PUNCT
admet-276	477	61	h.	h.	PROPN
admet-276	477	62	koeppen	koeppen	PROPN
admet-276	477	63	,	,	PUNCT
admet-276	477	64	c.	c.	PROPN
admet-276	477	65	nelson	nelson	PROPN
admet-276	477	66	,	,	PUNCT
admet-276	477	67	s.	s.	PROPN
admet-276	477	68	prabhu	prabhu	PROPN
admet-276	477	69	,	,	PUNCT
admet-276	477	70	h.	h.	PROPN
admet-276	477	71	raab	raab	PROPN
admet-276	477	72	,	,	PUNCT
admet-276	477	73	s.	s.	PROPN
admet-276	477	74	ross	ross	PROPN
admet-276	477	75	,	,	PUNCT
admet-276	477	76	j.p	j.p	PROPN
admet-276	477	77	.	.	PROPN
admet-276	477	78	stephan	stephan	PROPN
admet-276	477	79	,	,	PUNCT
admet-276	477	80	s.j	s.j	PROPN
admet-276	477	81	.	.	PROPN
admet-276	477	82	scales	scales	PROPN
admet-276	477	83	,	,	PUNCT
admet-276	477	84	s.d	s.d	PROPN
admet-276	477	85	.	.	PROPN
admet-276	477	86	spencer	spencer	PROPN
admet-276	477	87	,	,	PUNCT
admet-276	477	88	r.	r.	PROPN
admet-276	477	89	vandlen	vandlen	PROPN
admet-276	477	90	,	,	PUNCT
admet-276	477	91	b.	b.	PROPN
admet-276	477	92	wranik	wranik	PROPN
admet-276	477	93	,	,	PUNCT
admet-276	477	94	s.f	s.f	PROPN
admet-276	477	95	.	.	PROPN
admet-276	477	96	yu	yu	PROPN
admet-276	477	97	,	,	PUNCT
admet-276	477	98	b.	b.	PROPN
admet-276	477	99	zheng	zheng	PROPN
admet-276	477	100	,	,	PUNCT
admet-276	477	101	a.	a.	NOUN
admet-276	477	102	ebens	eben	NOUN
admet-276	477	103	.	.	PUNCT
admet-276	478	1	cancer	cancer	NOUN
admet-276	478	2	res	re	NOUN
admet-276	478	3	.	.	PUNCT
admet-276	479	1	69	69	NUM
admet-276	479	2	(	(	PUNCT
admet-276	479	3	2009	2009	NUM
admet-276	479	4	)	)	PUNCT
admet-276	479	5	2358	2358	NUM
admet-276	479	6	-	-	SYM
admet-276	479	7	2364	2364	NUM
admet-276	479	8	.	.	PUNCT
admet-276	480	1	[	[	X
admet-276	480	2	50	50	NUM
admet-276	480	3	]	]	X
admet-276	480	4	j.r	j.r	PROPN
admet-276	480	5	.	.	PROPN
admet-276	480	6	junutula	junutula	PROPN
admet-276	480	7	,	,	PUNCT
admet-276	480	8	h.	h.	PROPN
admet-276	480	9	raab	raab	PROPN
admet-276	480	10	,	,	PUNCT
admet-276	480	11	s.	s.	PROPN
admet-276	480	12	clark	clark	PROPN
admet-276	480	13	,	,	PUNCT
admet-276	480	14	s.	s.	PROPN
admet-276	480	15	bhakta	bhakta	PROPN
admet-276	480	16	,	,	PUNCT
admet-276	480	17	d.d	d.d	PROPN
admet-276	480	18	.	.	PROPN
admet-276	480	19	leipold	leipold	PROPN
admet-276	480	20	,	,	PUNCT
admet-276	480	21	s.	s.	PROPN
admet-276	480	22	weir	weir	PROPN
admet-276	480	23	,	,	PUNCT
admet-276	480	24	y.	y.	PROPN
admet-276	480	25	chen	chen	PROPN
admet-276	480	26	,	,	PUNCT
admet-276	480	27	m.	m.	PROPN
admet-276	480	28	simpson	simpson	PROPN
admet-276	480	29	,	,	PUNCT
admet-276	480	30	s.p	s.p	PROPN
admet-276	480	31	.	.	PROPN
admet-276	480	32	tsai	tsai	PROPN
admet-276	480	33	,	,	PUNCT
admet-276	480	34	m.s	m.s	PROPN
admet-276	480	35	.	.	PROPN
admet-276	480	36	dennis	dennis	PROPN
admet-276	480	37	,	,	PUNCT
admet-276	480	38	y.	y.	PROPN
admet-276	480	39	lu	lu	PROPN
admet-276	480	40	,	,	PUNCT
admet-276	480	41	y.g	y.g	PROPN
admet-276	480	42	.	.	PUNCT
admet-276	480	43	meng	meng	PROPN
admet-276	480	44	,	,	PUNCT
admet-276	480	45	c.	c.	PROPN
admet-276	480	46	ng	ng	PROPN
admet-276	480	47	,	,	PUNCT
admet-276	480	48	j.	j.	PROPN
admet-276	480	49	yang	yang	PROPN
admet-276	480	50	,	,	PUNCT
admet-276	480	51	c.c	c.c	PROPN
admet-276	480	52	.	.	PROPN
admet-276	480	53	lee	lee	PROPN
admet-276	480	54	,	,	PUNCT
admet-276	480	55	e.	e.	PROPN
admet-276	480	56	duenas	duenas	PROPN
admet-276	480	57	,	,	PUNCT
admet-276	480	58	j.	j.	PROPN
admet-276	480	59	gorrell	gorrell	PROPN
admet-276	480	60	,	,	PUNCT
admet-276	480	61	v.	v.	PROPN
admet-276	480	62	katta	katta	PROPN
admet-276	480	63	,	,	PUNCT
admet-276	480	64	a.	a.	PROPN
admet-276	480	65	kim	kim	PROPN
admet-276	480	66	,	,	PUNCT
admet-276	480	67	k.	k.	PROPN
admet-276	480	68	mcdorman	mcdorman	PROPN
admet-276	480	69	,	,	PUNCT
admet-276	480	70	k.	k.	PROPN
admet-276	480	71	flagella	flagella	PROPN
admet-276	480	72	,	,	PUNCT
admet-276	480	73	r.	r.	PROPN
admet-276	480	74	venook	venook	PROPN
admet-276	480	75	,	,	PUNCT
admet-276	480	76	s.	s.	PROPN
admet-276	480	77	ross	ross	PROPN
admet-276	480	78	,	,	PUNCT
admet-276	480	79	s.d	s.d	PROPN
admet-276	480	80	.	.	PROPN
admet-276	480	81	spencer	spencer	PROPN
admet-276	480	82	,	,	PUNCT
admet-276	480	83	w.l	w.l	PROPN
admet-276	480	84	.	.	PROPN
admet-276	480	85	wong	wong	PROPN
admet-276	480	86	,	,	PUNCT
admet-276	480	87	h.b	h.b	PROPN
admet-276	480	88	.	.	PROPN
admet-276	480	89	lowman	lowman	PROPN
admet-276	480	90	,	,	PUNCT
admet-276	480	91	r.	r.	PROPN
admet-276	480	92	vandlen	vandlen	PROPN
admet-276	480	93	,	,	PUNCT
admet-276	480	94	m.x	m.x	PROPN
admet-276	480	95	.	.	PROPN
admet-276	480	96	sliwkowski	sliwkowski	PROPN
admet-276	480	97	,	,	PUNCT
admet-276	480	98	r.h	r.h	PROPN
admet-276	480	99	.	.	PROPN
admet-276	480	100	scheller	scheller	NOUN
admet-276	480	101	,	,	PUNCT
admet-276	480	102	p.	p.	NOUN
admet-276	480	103	polakis	polakis	PROPN
admet-276	480	104	,	,	PUNCT
admet-276	480	105	w.	w.	PROPN
admet-276	480	106	mallet	mallet	NOUN
admet-276	480	107	.	.	PUNCT
admet-276	481	1	nat	nat	PROPN
admet-276	481	2	.	.	PUNCT
admet-276	482	1	biotechnol	biotechnol	PROPN
admet-276	482	2	.	.	PUNCT
admet-276	483	1	26	26	NUM
admet-276	483	2	(	(	PUNCT
admet-276	483	3	2008	2008	NUM
admet-276	483	4	)	)	PUNCT
admet-276	483	5	925	925	NUM
admet-276	483	6	-	-	SYM
admet-276	483	7	932	932	NUM
admet-276	483	8	.	.	PUNCT
admet-276	484	1	[	[	X
admet-276	484	2	51	51	NUM
admet-276	484	3	]	]	X
admet-276	484	4	n.k	n.k	PROPN
admet-276	484	5	.	.	PROPN
admet-276	484	6	damle	damle	PROPN
admet-276	484	7	.	.	PUNCT
admet-276	485	1	nat	nat	PROPN
admet-276	485	2	.	.	PUNCT
admet-276	486	1	biotechnol	biotechnol	PROPN
admet-276	486	2	.	.	PUNCT
admet-276	487	1	26	26	NUM
admet-276	487	2	(	(	PUNCT
admet-276	487	3	2008	2008	NUM
admet-276	487	4	)	)	PUNCT
admet-276	487	5	884	884	NUM
admet-276	487	6	-	-	SYM
admet-276	487	7	885	885	NUM
admet-276	487	8	.	.	PUNCT
admet-276	488	1	[	[	X
admet-276	488	2	52	52	NUM
admet-276	488	3	]	]	PUNCT
admet-276	488	4	p.	p.	NOUN
admet-276	488	5	dennler	dennler	PROPN
admet-276	488	6	,	,	PUNCT
admet-276	488	7	a.	a.	NOUN
admet-276	488	8	chiotellis	chiotellis	PROPN
admet-276	488	9	,	,	PUNCT
admet-276	488	10	e.	e.	PROPN
admet-276	488	11	fischer	fischer	PROPN
admet-276	488	12	,	,	PUNCT
admet-276	488	13	d.	d.	PROPN
admet-276	488	14	brégeon	brégeon	PROPN
admet-276	488	15	,	,	PUNCT
admet-276	488	16	c.	c.	PROPN
admet-276	488	17	belmant	belmant	PROPN
admet-276	488	18	,	,	PUNCT
admet-276	488	19	l.	l.	PROPN
admet-276	488	20	gauthier	gauthier	PROPN
admet-276	488	21	,	,	PUNCT
admet-276	488	22	f.	f.	PROPN
admet-276	488	23	lhospice	lhospice	PROPN
admet-276	488	24	,	,	PUNCT
admet-276	488	25	f.	f.	PROPN
admet-276	488	26	romagne	romagne	PROPN
admet-276	488	27	,	,	PUNCT
admet-276	488	28	r.	r.	PROPN
admet-276	488	29	schibli	schibli	PROPN
admet-276	488	30	.	.	PUNCT
admet-276	489	1	bioconjug	bioconjug	NOUN
admet-276	489	2	.	.	PUNCT
admet-276	490	1	chem	chem	NOUN
admet-276	490	2	.	.	PUNCT
admet-276	491	1	25	25	NUM
admet-276	491	2	(	(	PUNCT
admet-276	491	3	2014	2014	NUM
admet-276	491	4	)	)	PUNCT
admet-276	491	5	569	569	NUM
admet-276	491	6	-	-	SYM
admet-276	491	7	578	578	NUM
admet-276	491	8	.	.	PUNCT
admet-276	492	1	[	[	X
admet-276	492	2	53	53	NUM
admet-276	492	3	]	]	X
admet-276	492	4	p.f	p.f	PROPN
admet-276	492	5	.	.	PROPN
admet-276	492	6	peddi	peddi	PROPN
admet-276	492	7	,	,	PUNCT
admet-276	492	8	s.a	s.a	PROPN
admet-276	492	9	.	.	PROPN
admet-276	492	10	hurvitz	hurvitz	PROPN
admet-276	492	11	.	.	PUNCT
admet-276	493	1	future	future	ADJ
admet-276	493	2	oncol	oncol	ADJ
admet-276	493	3	.	.	PUNCT
admet-276	494	1	9	9	NUM
admet-276	494	2	(	(	PUNCT
admet-276	494	3	2013	2013	NUM
admet-276	494	4	)	)	PUNCT
admet-276	494	5	319	319	NUM
admet-276	494	6	-	-	SYM
admet-276	494	7	326	326	NUM
admet-276	494	8	.	.	PUNCT
admet-276	495	1	[	[	X
admet-276	495	2	54	54	NUM
admet-276	495	3	]	]	SYM
admet-276	495	4	h.k	h.k	PROPN
admet-276	495	5	.	.	PROPN
admet-276	495	6	erickson	erickson	PROPN
admet-276	495	7	,	,	PUNCT
admet-276	495	8	j.m	j.m	PROPN
admet-276	495	9	.	.	PROPN
admet-276	495	10	lambert	lambert	PROPN
admet-276	495	11	.	.	PUNCT
admet-276	496	1	aaps	aaps	PROPN
admet-276	496	2	j.	j.	PROPN
admet-276	496	3	14	14	NUM
admet-276	496	4	(	(	PUNCT
admet-276	496	5	2012	2012	NUM
admet-276	496	6	)	)	PUNCT
admet-276	496	7	799	799	NUM
admet-276	496	8	-	-	SYM
admet-276	496	9	805	805	NUM
admet-276	496	10	.	.	PUNCT
admet-276	497	1	[	[	X
admet-276	497	2	55	55	NUM
admet-276	497	3	]	]	SYM
admet-276	497	4	ich	ich	PROPN
admet-276	497	5	.	.	PUNCT
admet-276	498	1	guidance	guidance	NOUN
admet-276	498	2	for	for	ADP
admet-276	498	3	industry	industry	NOUN
admet-276	498	4	:	:	PUNCT
admet-276	498	5	s6(r1	s6(r1	NOUN
admet-276	498	6	):	):	PUNCT
admet-276	498	7	preclinical	preclinical	ADJ
admet-276	498	8	safety	safety	NOUN
admet-276	498	9	evaluation	evaluation	NOUN
admet-276	498	10	of	of	ADP
admet-276	498	11	biotechnology	biotechnology	NOUN
admet-276	498	12	-	-	PUNCT
admet-276	498	13	derived	derive	VERB
admet-276	498	14	pharmaceuticals	pharmaceutical	NOUN
admet-276	498	15	.	.	PUNCT
admet-276	499	1	(	(	PUNCT
admet-276	499	2	2012	2012	NUM
admet-276	499	3	)	)	PUNCT
admet-276	499	4	available	available	ADJ
admet-276	499	5	from	from	ADP
admet-276	499	6	:	:	PUNCT
admet-276	499	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm	PROPN
admet-276	499	8	194490.pdf	194490.pdf	PROPN
admet-276	499	9	.	.	PUNCT
admet-276	500	1	(	(	PUNCT
admet-276	500	2	accessed	access	VERB
admet-276	500	3	on	on	ADP
admet-276	500	4	march	march	PROPN
admet-276	500	5	23	23	NUM
admet-276	500	6	,	,	PUNCT
admet-276	500	7	2016	2016	NUM
admet-276	500	8	)	)	PUNCT
admet-276	500	9	.	.	PUNCT
admet-276	501	1	[	[	X
admet-276	501	2	56	56	NUM
admet-276	501	3	]	]	X
admet-276	501	4	m.b	m.b	PROPN
admet-276	501	5	.	.	PROPN
admet-276	501	6	hock	hock	PROPN
admet-276	501	7	,	,	PUNCT
admet-276	501	8	k.e	k.e	PROPN
admet-276	501	9	.	.	PROPN
admet-276	501	10	thudium	thudium	PROPN
admet-276	501	11	,	,	PUNCT
admet-276	501	12	m.	m.	NOUN
admet-276	501	13	carrasco	carrasco	PROPN
admet-276	501	14	-	-	PUNCT
admet-276	501	15	triguero	triguero	PROPN
admet-276	501	16	,	,	PUNCT
admet-276	501	17	n.f	n.f	PROPN
admet-276	501	18	.	.	PROPN
admet-276	501	19	schwabe	schwabe	PROPN
admet-276	501	20	.	.	PUNCT
admet-276	502	1	aaps	aaps	PROPN
admet-276	502	2	j.	j.	PROPN
admet-276	502	3	17	17	NUM
admet-276	502	4	(	(	PUNCT
admet-276	502	5	2015	2015	NUM
admet-276	502	6	)	)	PUNCT
admet-276	502	7	35	35	NUM
admet-276	502	8	-	-	SYM
admet-276	502	9	43	43	NUM
admet-276	502	10	.	.	PUNCT
admet-276	503	1	[	[	X
admet-276	503	2	57	57	NUM
admet-276	503	3	]	]	X
admet-276	503	4	fda	fda	PROPN
admet-276	503	5	.	.	PUNCT
admet-276	503	6	guidance	guidance	NOUN
admet-276	503	7	for	for	ADP
admet-276	503	8	industry	industry	NOUN
admet-276	503	9	:	:	PUNCT
admet-276	503	10	s9	s9	VERB
admet-276	503	11	nonclinical	nonclinical	ADJ
admet-276	503	12	evaluation	evaluation	NOUN
admet-276	503	13	for	for	ADP
admet-276	503	14	anticancer	anticancer	NOUN
admet-276	503	15	pharmaceuticals	pharmaceutical	NOUN
admet-276	503	16	.	.	PUNCT
admet-276	504	1	(	(	PUNCT
admet-276	504	2	2010	2010	NUM
admet-276	504	3	)	)	PUNCT
admet-276	504	4	available	available	ADJ
admet-276	504	5	from	from	ADP
admet-276	504	6	:	:	PUNCT
admet-276	504	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm08	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm08	NOUN
admet-276	504	8	5389.pdf	5389.pdf	PROPN
admet-276	504	9	.	.	PUNCT
admet-276	505	1	(	(	PUNCT
admet-276	505	2	accessed	access	VERB
admet-276	505	3	on	on	ADP
admet-276	505	4	march	march	PROPN
admet-276	505	5	23	23	NUM
admet-276	505	6	,	,	PUNCT
admet-276	505	7	2016	2016	NUM
admet-276	505	8	)	)	PUNCT
admet-276	505	9	.	.	PUNCT
admet-276	506	1	[	[	X
admet-276	506	2	58	58	NUM
admet-276	506	3	]	]	PUNCT
admet-276	506	4	s.	s.	PROPN
admet-276	506	5	girish	girish	PROPN
admet-276	506	6	,	,	PUNCT
admet-276	506	7	m.	m.	NOUN
admet-276	506	8	gupta	gupta	PROPN
admet-276	506	9	,	,	PUNCT
admet-276	506	10	b.	b.	PROPN
admet-276	506	11	wang	wang	PROPN
admet-276	506	12	,	,	PUNCT
admet-276	506	13	d.	d.	PROPN
admet-276	506	14	lu	lu	PROPN
admet-276	506	15	,	,	PUNCT
admet-276	506	16	i.e.	i.e.	X
admet-276	506	17	krop	krop	PROPN
admet-276	506	18	,	,	PUNCT
admet-276	506	19	c.l	c.l	PROPN
admet-276	506	20	.	.	PROPN
admet-276	506	21	vogel	vogel	PROPN
admet-276	506	22	,	,	PUNCT
admet-276	506	23	h.a	h.a	PROPN
admet-276	506	24	.	.	PROPN
admet-276	506	25	burris	burris	PROPN
admet-276	506	26	iii	iii	PROPN
admet-276	506	27	,	,	PUNCT
admet-276	506	28	p.m.	p.m.	NOUN
admet-276	506	29	lorusso	lorusso	PROPN
admet-276	506	30	,	,	PUNCT
admet-276	506	31	j.h	j.h	PROPN
admet-276	506	32	.	.	PROPN
admet-276	506	33	yi	yi	PROPN
admet-276	506	34	,	,	PUNCT
admet-276	506	35	o.	o.	PROPN
admet-276	506	36	saad	saad	PROPN
admet-276	506	37	,	,	PUNCT
admet-276	506	38	b.	b.	PROPN
admet-276	506	39	tong	tong	PROPN
admet-276	506	40	,	,	PUNCT
admet-276	506	41	y.w	y.w	PROPN
admet-276	506	42	.	.	PROPN
admet-276	506	43	chu	chu	PROPN
admet-276	506	44	,	,	PUNCT
admet-276	506	45	s.	s.	PROPN
admet-276	506	46	holden	holden	PROPN
admet-276	506	47	,	,	PUNCT
admet-276	506	48	a.	a.	PROPN
admet-276	506	49	joshi	joshi	PROPN
admet-276	506	50	.	.	PUNCT
admet-276	507	1	cancer	cancer	PROPN
admet-276	507	2	chemother	chemother	PROPN
admet-276	507	3	.	.	PUNCT
admet-276	508	1	pharmacol	pharmacol	PROPN
admet-276	508	2	.	.	PUNCT
admet-276	509	1	69	69	NUM
admet-276	509	2	(	(	PUNCT
admet-276	509	3	2012	2012	NUM
admet-276	509	4	)	)	PUNCT
admet-276	509	5	1229	1229	NUM
admet-276	509	6	-	-	SYM
admet-276	509	7	1240	1240	NUM
admet-276	509	8	.	.	PUNCT
admet-276	510	1	[	[	X
admet-276	510	2	59	59	NUM
admet-276	510	3	]	]	X
admet-276	510	4	fda	fda	PROPN
admet-276	510	5	.	.	PUNCT
admet-276	510	6	guidance	guidance	NOUN
admet-276	510	7	for	for	ADP
admet-276	510	8	industry	industry	NOUN
admet-276	510	9	:	:	PUNCT
admet-276	510	10	bioanalytical	bioanalytical	ADJ
admet-276	510	11	method	method	NOUN
admet-276	510	12	validation	validation	NOUN
admet-276	510	13	.	.	PUNCT
admet-276	511	1	(	(	PUNCT
admet-276	511	2	2001	2001	NUM
admet-276	511	3	)	)	PUNCT
admet-276	511	4	available	available	ADJ
admet-276	511	5	from	from	ADP
admet-276	511	6	:	:	PUNCT
admet-276	511	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm0701	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm0701	PROPN
admet-276	511	8	07.pdf	07.pdf	PROPN
admet-276	511	9	.	.	PUNCT
admet-276	512	1	(	(	PUNCT
admet-276	512	2	accessed	access	VERB
admet-276	512	3	on	on	ADP
admet-276	512	4	march	march	PROPN
admet-276	512	5	23	23	NUM
admet-276	512	6	,	,	PUNCT
admet-276	512	7	2016	2016	NUM
admet-276	512	8	)	)	PUNCT
admet-276	512	9	.	.	PUNCT
admet-276	513	1	[	[	X
admet-276	513	2	60	60	NUM
admet-276	513	3	]	]	PUNCT
admet-276	513	4	r.	r.	PROPN
admet-276	513	5	dere	dere	PROPN
admet-276	513	6	,	,	PUNCT
admet-276	513	7	j.h	j.h	PROPN
admet-276	513	8	.	.	PROPN
admet-276	513	9	yi	yi	PROPN
admet-276	513	10	,	,	PUNCT
admet-276	513	11	c.	c.	PROPN
admet-276	513	12	lei	lei	PROPN
admet-276	513	13	,	,	PUNCT
admet-276	513	14	o.m	o.m	PROPN
admet-276	513	15	.	.	PROPN
admet-276	513	16	saad	saad	PROPN
admet-276	513	17	,	,	PUNCT
admet-276	513	18	c.	c.	PROPN
admet-276	513	19	huang	huang	PROPN
admet-276	513	20	,	,	PUNCT
admet-276	513	21	y.	y.	PROPN
admet-276	513	22	li	li	PROPN
admet-276	513	23	,	,	PUNCT
admet-276	513	24	j.	j.	PROPN
admet-276	513	25	baudys	baudys	PROPN
admet-276	513	26	,	,	PUNCT
admet-276	513	27	s.	s.	PROPN
admet-276	513	28	kaur	kaur	PROPN
admet-276	513	29	.	.	PUNCT
admet-276	514	1	bioanalysis	bioanalysis	NOUN
admet-276	514	2	5	5	NUM
admet-276	514	3	(	(	PUNCT
admet-276	514	4	2013	2013	NUM
admet-276	514	5	)	)	PUNCT
admet-276	514	6	1025	1025	NUM
admet-276	514	7	-	-	SYM
admet-276	514	8	1040	1040	NUM
admet-276	514	9	.	.	PUNCT
admet-276	515	1	[	[	X
admet-276	515	2	61	61	NUM
admet-276	515	3	]	]	X
admet-276	515	4	e.	e.	PROPN
admet-276	515	5	ezan	ezan	PROPN
admet-276	515	6	,	,	PUNCT
admet-276	515	7	m.	m.	PROPN
admet-276	515	8	dubois	dubois	PROPN
admet-276	515	9	,	,	PUNCT
admet-276	515	10	f.	f.	PROPN
admet-276	515	11	becher	becher	PROPN
admet-276	515	12	.	.	PUNCT
admet-276	516	1	analyst	analyst	NOUN
admet-276	516	2	134	134	NUM
admet-276	516	3	(	(	PUNCT
admet-276	516	4	2009	2009	NUM
admet-276	516	5	)	)	PUNCT
admet-276	516	6	825	825	NUM
admet-276	516	7	-	-	SYM
admet-276	516	8	834	834	NUM
admet-276	516	9	.	.	PUNCT
admet-276	517	1	[	[	X
admet-276	517	2	62	62	NUM
admet-276	517	3	]	]	X
admet-276	517	4	b.	b.	PROPN
admet-276	517	5	gorovits	gorovits	PROPN
admet-276	517	6	,	,	PUNCT
admet-276	517	7	s.c	s.c	PROPN
admet-276	517	8	.	.	PROPN
admet-276	517	9	alley	alley	PROPN
admet-276	517	10	,	,	PUNCT
admet-276	517	11	s.	s.	PROPN
admet-276	517	12	bilić	bilić	PROPN
admet-276	517	13	,	,	PUNCT
admet-276	517	14	b.	b.	PROPN
admet-276	517	15	booth	booth	PROPN
admet-276	517	16	,	,	PUNCT
admet-276	517	17	s.	s.	PROPN
admet-276	517	18	kaur	kaur	PROPN
admet-276	517	19	,	,	PUNCT
admet-276	517	20	p.	p.	PROPN
admet-276	517	21	oldfield	oldfield	PROPN
admet-276	517	22	,	,	PUNCT
admet-276	517	23	s.	s.	PROPN
admet-276	517	24	purushothama	purushothama	PROPN
admet-276	517	25	,	,	PUNCT
admet-276	517	26	c.	c.	PROPN
admet-276	517	27	rao	rao	PROPN
admet-276	517	28	,	,	PUNCT
admet-276	517	29	s.	s.	PROPN
admet-276	517	30	shord	shord	PROPN
admet-276	517	31	,	,	PUNCT
admet-276	517	32	p.	p.	NOUN
admet-276	517	33	siguenza	siguenza	NOUN
admet-276	517	34	.	.	PUNCT
admet-276	518	1	bioanalysis	bioanalysis	NOUN
admet-276	518	2	5	5	NUM
admet-276	518	3	(	(	PUNCT
admet-276	518	4	2013	2013	NUM
admet-276	518	5	)	)	PUNCT
admet-276	518	6	997	997	NUM
admet-276	518	7	-	-	SYM
admet-276	518	8	1006	1006	NUM
admet-276	518	9	.	.	PUNCT
admet-276	519	1	[	[	X
admet-276	519	2	63	63	NUM
admet-276	519	3	]	]	X
admet-276	519	4	y.m	y.m	PROPN
admet-276	519	5	.	.	PROPN
admet-276	519	6	wang	wang	PROPN
admet-276	519	7	,	,	PUNCT
admet-276	519	8	v.	v.	PROPN
admet-276	519	9	jawa	jawa	PROPN
admet-276	519	10	,	,	PUNCT
admet-276	519	11	m.	m.	PROPN
admet-276	519	12	ma	ma	PROPN
admet-276	519	13	.	.	PROPN
admet-276	519	14	bioanalysis	bioanalysis	PROPN
admet-276	519	15	6	6	NUM
admet-276	519	16	(	(	PUNCT
admet-276	519	17	2014	2014	NUM
admet-276	519	18	)	)	PUNCT
admet-276	519	19	79	79	NUM
admet-276	519	20	-	-	SYM
admet-276	519	21	87	87	NUM
admet-276	519	22	.	.	PUNCT
admet-276	520	1	[	[	X
admet-276	520	2	64	64	NUM
admet-276	520	3	]	]	PUNCT
admet-276	520	4	l.	l.	PROPN
admet-276	520	5	stevenson	stevenson	PROPN
admet-276	520	6	,	,	PUNCT
admet-276	520	7	l.	l.	PROPN
admet-276	520	8	amaravadi	amaravadi	PROPN
admet-276	520	9	,	,	PUNCT
admet-276	520	10	h.	h.	PROPN
admet-276	520	11	myler	myler	PROPN
admet-276	520	12	,	,	PUNCT
admet-276	520	13	l.	l.	PROPN
admet-276	520	14	salazar	salazar	PROPN
admet-276	520	15	-	-	PUNCT
admet-276	520	16	fontana	fontana	PROPN
admet-276	520	17	,	,	PUNCT
admet-276	520	18	b.	b.	PROPN
admet-276	520	19	gorovits	gorovits	PROPN
admet-276	520	20	,	,	PUNCT
admet-276	520	21	s.	s.	PROPN
admet-276	520	22	kirshner	kirshner	PROPN
admet-276	520	23	,	,	PUNCT
admet-276	520	24	l.	l.	PROPN
admet-276	520	25	xue	xue	PROPN
admet-276	520	26	,	,	PUNCT
admet-276	520	27	f.	f.	PROPN
admet-276	520	28	garofolo	garofolo	PROPN
admet-276	520	29	,	,	PUNCT
admet-276	520	30	s.c	s.c	PROPN
admet-276	520	31	.	.	PROPN
admet-276	520	32	alley	alley	PROPN
admet-276	520	33	,	,	PUNCT
admet-276	520	34	t.	t.	PROPN
admet-276	520	35	thway	thway	PROPN
admet-276	520	36	,	,	PUNCT
admet-276	520	37	a.	a.	PROPN
admet-276	520	38	joyce	joyce	PROPN
admet-276	520	39	,	,	PUNCT
admet-276	520	40	s.	s.	PROPN
admet-276	520	41	bansal	bansal	PROPN
admet-276	520	42	,	,	PUNCT
admet-276	520	43	c.	c.	PROPN
admet-276	520	44	beaver	beaver	PROPN
admet-276	520	45	,	,	PUNCT
admet-276	520	46	a.	a.	PROPN
admet-276	520	47	bergeron	bergeron	PROPN
admet-276	520	48	,	,	PUNCT
admet-276	520	49	x.y	x.y	PROPN
admet-276	520	50	.	.	PROPN
admet-276	520	51	cai	cai	PROPN
admet-276	520	52	,	,	PUNCT
admet-276	520	53	l.	l.	PROPN
admet-276	520	54	cojocaru	cojocaru	PROPN
admet-276	520	55	,	,	PUNCT
admet-276	520	56	b.	b.	PROPN
admet-276	520	57	desilva	desilva	PROPN
admet-276	520	58	,	,	PUNCT
admet-276	520	59	i.dumont	i.dumont	PROPN
admet-276	520	60	,	,	PUNCT
admet-276	520	61	e.	e.	PROPN
admet-276	520	62	fluhler	fluhler	PROPN
admet-276	520	63	,	,	PUNCT
admet-276	520	64	s.	s.	PROPN
admet-276	520	65	fraser	fraser	PROPN
admet-276	520	66	,	,	PUNCT
admet-276	520	67	d.	d.	PROPN
admet-276	520	68	gouty	gouty	PROPN
admet-276	520	69	,	,	PUNCT
admet-276	520	70	s.	s.	PROPN
admet-276	520	71	gupta	gupta	PROPN
admet-276	520	72	,	,	PUNCT
admet-276	520	73	s.	s.	PROPN
admet-276	520	74	haidar	haidar	PROPN
admet-276	520	75	,	,	PUNCT
admet-276	520	76	r.	r.	PROPN
admet-276	520	77	hayes	hayes	PROPN
admet-276	520	78	,	,	PUNCT
admet-276	520	79	b.	b.	PROPN
admet-276	520	80	ingelse	ingelse	PROPN
admet-276	520	81	,	,	PUNCT
admet-276	520	82	a.	a.	NOUN
admet-276	520	83	ishii	ishii	PROPN
admet-276	520	84	-	-	PUNCT
admet-276	520	85	watabe	watabe	PROPN
admet-276	520	86	,	,	PUNCT
admet-276	520	87	s.	s.	PROPN
admet-276	520	88	kaur	kaur	PROPN
admet-276	520	89	,	,	PUNCT
admet-276	520	90	l.	l.	PROPN
admet-276	520	91	king	king	PROPN
admet-276	520	92	,	,	PUNCT
admet-276	520	93	o.	o.	PROPN
admet-276	520	94	laterza	laterza	PROPN
admet-276	520	95	,	,	PUNCT
admet-276	520	96	s.	s.	PROPN
admet-276	520	97	leung	leung	PROPN
admet-276	520	98	,	,	PUNCT
admet-276	520	99	a.	a.	NOUN
admet-276	520	100	lévesque	lévesque	PROPN
admet-276	520	101	,	,	PUNCT
admet-276	520	102	m.	m.	PROPN
admet-276	520	103	ma	ma	PROPN
admet-276	520	104	,	,	PUNCT
admet-276	520	105	c.	c.	PROPN
admet-276	520	106	petit	petit	PROPN
admet-276	520	107	-	-	PUNCT
admet-276	520	108	frere	frere	PROPN
admet-276	520	109	,	,	PUNCT
admet-276	520	110	r.	r.	PROPN
admet-276	520	111	pillutla	pillutla	PROPN
admet-276	520	112	,	,	PUNCT
admet-276	520	113	m.	m.	NOUN
admet-276	520	114	rose	rise	VERB
admet-276	520	115	,	,	PUNCT
admet-276	520	116	g.	g.	PROPN
admet-276	520	117	schultz	schultz	PROPN
admet-276	520	118	,	,	PUNCT
admet-276	520	119	j.	j.	PROPN
admet-276	520	120	smeraglia	smeraglia	PROPN
admet-276	520	121	,	,	PUNCT
admet-276	520	122	s.	s.	PROPN
admet-276	520	123	swanson	swanson	PROPN
admet-276	520	124	,	,	PUNCT
admet-276	520	125	a.	a.	NOUN
admet-276	520	126	torri	torri	PROPN
admet-276	520	127	,	,	PUNCT
admet-276	520	128	f.	f.	PROPN
admet-276	520	129	vazvaei	vazvaei	PROPN
admet-276	520	130	,	,	PUNCT
admet-276	520	131	j.	j.	PROPN
admet-276	520	132	wakelin	wakelin	PROPN
admet-276	520	133	-	-	PUNCT
admet-276	520	134	smith	smith	PROPN
admet-276	520	135	,	,	PUNCT
admet-276	520	136	a.	a.	PROPN
admet-276	520	137	wilson	wilson	PROPN
admet-276	520	138	,	,	PUNCT
admet-276	520	139	e.	e.	PROPN
admet-276	520	140	woolf	woolf	PROPN
admet-276	520	141	,	,	PUNCT
admet-276	520	142	t.y	t.y	PROPN
admet-276	520	143	.	.	PROPN
admet-276	520	144	yang	yang	PROPN
admet-276	520	145	.	.	PUNCT
admet-276	521	1	bioanalysis	bioanalysis	PROPN
admet-276	521	2	6	6	NUM
admet-276	521	3	(	(	PUNCT
admet-276	521	4	2014	2014	NUM
admet-276	521	5	)	)	PUNCT
admet-276	521	6	3355	3355	NUM
admet-276	521	7	-	-	SYM
admet-276	521	8	3368	3368	NUM
admet-276	521	9	.	.	PUNCT
admet-276	522	1	hong	hong	PROPN
admet-276	522	2	wan	wan	PROPN
admet-276	522	3	admet	admet	PROPN
admet-276	522	4	&	&	CCONJ
admet-276	522	5	dmpk	dmpk	PROPN
admet-276	522	6	4(1	4(1	NOUN
admet-276	522	7	)	)	PUNCT
admet-276	522	8	(	(	PUNCT
admet-276	522	9	2016	2016	NUM
admet-276	522	10	)	)	PUNCT
admet-276	522	11	1	1	NUM
admet-276	522	12	-	-	SYM
admet-276	522	13	22	22	NUM
admet-276	522	14	20	20	NUM
admet-276	522	15	[	[	SYM
admet-276	522	16	65	65	NUM
admet-276	522	17	]	]	X
admet-276	522	18	l.	l.	PROPN
admet-276	522	19	stevenson	stevenson	PROPN
admet-276	522	20	,	,	PUNCT
admet-276	522	21	f.	f.	PROPN
admet-276	522	22	garofolo	garofolo	PROPN
admet-276	522	23	,	,	PUNCT
admet-276	522	24	b.	b.	PROPN
admet-276	522	25	desilva	desilva	PROPN
admet-276	522	26	,	,	PUNCT
admet-276	522	27	i.	i.	PROPN
admet-276	522	28	dumont	dumont	PROPN
admet-276	522	29	,	,	PUNCT
admet-276	522	30	s.	s.	PROPN
admet-276	522	31	martinez	martinez	PROPN
admet-276	522	32	,	,	PUNCT
admet-276	522	33	m.	m.	NOUN
admet-276	522	34	rocci	rocci	PROPN
admet-276	522	35	,	,	PUNCT
admet-276	522	36	l.	l.	PROPN
admet-276	522	37	amaravadi	amaravadi	PROPN
admet-276	522	38	,	,	PUNCT
admet-276	522	39	m.	m.	NOUN
admet-276	522	40	brudnykloeppel	brudnykloeppel	NOUN
admet-276	522	41	,	,	PUNCT
admet-276	522	42	a.	a.	NOUN
admet-276	522	43	musuku	musuku	PROPN
admet-276	522	44	,	,	PUNCT
admet-276	522	45	b.	b.	PROPN
admet-276	522	46	booth	booth	PROPN
admet-276	522	47	,	,	PUNCT
admet-276	522	48	c.	c.	PROPN
admet-276	522	49	dicaire	dicaire	PROPN
admet-276	522	50	,	,	PUNCT
admet-276	522	51	l.	l.	PROPN
admet-276	522	52	wright	wright	PROPN
admet-276	522	53	,	,	PUNCT
admet-276	522	54	l.	l.	PROPN
admet-276	522	55	mayrand	mayrand	PROPN
admet-276	522	56	-	-	PUNCT
admet-276	522	57	provencher	provencher	PROPN
admet-276	522	58	,	,	PUNCT
admet-276	522	59	m.	m.	NOUN
admet-276	522	60	losauro	losauro	PROPN
admet-276	522	61	,	,	PUNCT
admet-276	522	62	d.	d.	PROPN
admet-276	522	63	gouty	gouty	PROPN
admet-276	522	64	,	,	PUNCT
admet-276	522	65	m.	m.	NOUN
admet-276	522	66	arnold	arnold	PROPN
admet-276	522	67	,	,	PUNCT
admet-276	522	68	s.	s.	PROPN
admet-276	522	69	bansal	bansal	PROPN
admet-276	522	70	,	,	PUNCT
admet-276	522	71	s.	s.	PROPN
admet-276	522	72	dudal	dudal	PROPN
admet-276	522	73	,	,	PUNCT
admet-276	522	74	d.	d.	PROPN
admet-276	522	75	dufield	dufield	PROPN
admet-276	522	76	,	,	PUNCT
admet-276	522	77	j.	j.	PROPN
admet-276	522	78	duggan	duggan	PROPN
admet-276	522	79	,	,	PUNCT
admet-276	522	80	c.	c.	PROPN
admet-276	522	81	evans	evans	PROPN
admet-276	522	82	,	,	PUNCT
admet-276	522	83	e.	e.	PROPN
admet-276	522	84	fluhler	fluhler	PROPN
admet-276	522	85	,	,	PUNCT
admet-276	522	86	s.	s.	PROPN
admet-276	522	87	fraser	fraser	PROPN
admet-276	522	88	,	,	PUNCT
admet-276	522	89	b.	b.	PROPN
admet-276	522	90	gorovits	gorovits	PROPN
admet-276	522	91	,	,	PUNCT
admet-276	522	92	s.	s.	PROPN
admet-276	522	93	haidar	haidar	PROPN
admet-276	522	94	,	,	PUNCT
admet-276	522	95	r.	r.	PROPN
admet-276	522	96	hayes	hayes	PROPN
admet-276	522	97	,	,	PUNCT
admet-276	522	98	s.	s.	PROPN
admet-276	522	99	ho	ho	PROPN
admet-276	522	100	,	,	PUNCT
admet-276	522	101	r.	r.	PROPN
admet-276	522	102	houghton	houghton	PROPN
admet-276	522	103	,	,	PUNCT
admet-276	522	104	r.	r.	PROPN
admet-276	522	105	islam	islam	PROPN
admet-276	522	106	,	,	PUNCT
admet-276	522	107	r.	r.	PROPN
admet-276	522	108	jenkins	jenkins	PROPN
admet-276	522	109	,	,	PUNCT
admet-276	522	110	n.	n.	PROPN
admet-276	522	111	katori	katori	PROPN
admet-276	522	112	,	,	PUNCT
admet-276	522	113	s.	s.	PROPN
admet-276	522	114	kaur	kaur	PROPN
admet-276	522	115	,	,	PUNCT
admet-276	522	116	m.	m.	NOUN
admet-276	522	117	kelley	kelley	PROPN
admet-276	522	118	,	,	PUNCT
admet-276	522	119	m.	m.	NOUN
admet-276	522	120	knutsson	knutsson	PROPN
admet-276	522	121	,	,	PUNCT
admet-276	522	122	j.	j.	PROPN
admet-276	522	123	lee	lee	PROPN
admet-276	522	124	,	,	PUNCT
admet-276	522	125	h.	h.	PROPN
admet-276	522	126	liu	liu	PROPN
admet-276	522	127	,	,	PUNCT
admet-276	522	128	s.	s.	PROPN
admet-276	522	129	lowes	lowes	PROPN
admet-276	522	130	,	,	PUNCT
admet-276	522	131	m.	m.	PROPN
admet-276	522	132	ma	ma	PROPN
admet-276	522	133	,	,	PUNCT
admet-276	522	134	a.	a.	NOUN
admet-276	522	135	mikulskis	mikulskis	PROPN
admet-276	522	136	,	,	PUNCT
admet-276	522	137	h.	h.	PROPN
admet-276	522	138	myler	myler	PROPN
admet-276	522	139	,	,	PUNCT
admet-276	522	140	b.	b.	PROPN
admet-276	522	141	nicholson	nicholson	PROPN
admet-276	522	142	,	,	PUNCT
admet-276	522	143	t.	t.	PROPN
admet-276	522	144	olah	olah	PROPN
admet-276	522	145	,	,	PUNCT
admet-276	522	146	e.	e.	PROPN
admet-276	522	147	ormsby	ormsby	PROPN
admet-276	522	148	,	,	PUNCT
admet-276	522	149	s.	s.	PROPN
admet-276	522	150	patel	patel	PROPN
admet-276	522	151	,	,	PUNCT
admet-276	522	152	v.	v.	PROPN
admet-276	522	153	pucci	pucci	PROPN
admet-276	522	154	,	,	PUNCT
admet-276	522	155	c.	c.	PROPN
admet-276	522	156	ray	ray	PROPN
admet-276	522	157	,	,	PUNCT
admet-276	522	158	g.	g.	PROPN
admet-276	522	159	schultz	schultz	PROPN
admet-276	522	160	,	,	PUNCT
admet-276	522	161	j.	j.	PROPN
admet-276	522	162	shih	shih	PROPN
admet-276	522	163	,	,	PUNCT
admet-276	522	164	r.	r.	PROPN
admet-276	522	165	shoup	shoup	PROPN
admet-276	522	166	,	,	PUNCT
admet-276	522	167	c.	c.	PROPN
admet-276	522	168	simon	simon	PROPN
admet-276	522	169	,	,	PUNCT
admet-276	522	170	a.	a.	NOUN
admet-276	522	171	song	song	NOUN
admet-276	522	172	,	,	PUNCT
admet-276	522	173	j.t	j.t	PROPN
admet-276	522	174	.	.	PROPN
admet-276	522	175	neto	neto	PROPN
admet-276	522	176	,	,	PUNCT
admet-276	522	177	v.	v.	PROPN
admet-276	522	178	theobald	theobald	NOUN
admet-276	522	179	,	,	PUNCT
admet-276	522	180	t.	t.	PROPN
admet-276	522	181	thway	thway	PROPN
admet-276	522	182	,	,	PUNCT
admet-276	522	183	j.	j.	PROPN
admet-276	522	184	wakelin	wakelin	PROPN
admet-276	522	185	-	-	PUNCT
admet-276	522	186	smith	smith	PROPN
admet-276	522	187	,	,	PUNCT
admet-276	522	188	j.	j.	PROPN
admet-276	522	189	wang	wang	PROPN
admet-276	522	190	,	,	PUNCT
admet-276	522	191	l.	l.	PROPN
admet-276	522	192	wang	wang	PROPN
admet-276	522	193	,	,	PUNCT
admet-276	522	194	j.	j.	PROPN
admet-276	522	195	welink	welink	PROPN
admet-276	522	196	,	,	PUNCT
admet-276	522	197	e.	e.	PROPN
admet-276	522	198	whale	whale	PROPN
admet-276	522	199	,	,	PUNCT
admet-276	522	200	e.	e.	PROPN
admet-276	522	201	woolf	woolf	PROPN
admet-276	522	202	,	,	PUNCT
admet-276	522	203	r.	r.	PROPN
admet-276	522	204	xu	xu	PROPN
admet-276	522	205	.	.	PUNCT
admet-276	523	1	bioanalysis	bioanalysis	NOUN
admet-276	523	2	5	5	NUM
admet-276	523	3	(	(	PUNCT
admet-276	523	4	2013	2013	NUM
admet-276	523	5	)	)	PUNCT
admet-276	523	6	29032918	29032918	NUM
admet-276	523	7	.	.	PUNCT
admet-276	524	1	[	[	X
admet-276	524	2	66	66	NUM
admet-276	524	3	]	]	X
admet-276	524	4	d.	d.	PROPN
admet-276	524	5	l.	l.	PROPN
admet-276	524	6	chappell	chappell	PROPN
admet-276	524	7	,	,	PUNCT
admet-276	524	8	m.e	m.e	PROPN
admet-276	524	9	.	.	PROPN
admet-276	524	10	lassman	lassman	NOUN
admet-276	524	11	,	,	PUNCT
admet-276	524	12	t.	t.	PROPN
admet-276	524	13	mcavoy	mcavoy	PROPN
admet-276	524	14	,	,	PUNCT
admet-276	524	15	m.	m.	PROPN
admet-276	524	16	lin	lin	PROPN
admet-276	524	17	,	,	PUNCT
admet-276	524	18	d.s	d.s	PROPN
admet-276	524	19	.	.	PROPN
admet-276	524	20	spellman	spellman	PROPN
admet-276	524	21	,	,	PUNCT
admet-276	524	22	o.f	o.f	PROPN
admet-276	524	23	.	.	PROPN
admet-276	524	24	laterza	laterza	PROPN
admet-276	524	25	.	.	PUNCT
admet-276	525	1	bioanalysis	bioanalysis	NOUN
admet-276	525	2	6	6	NUM
admet-276	525	3	(	(	PUNCT
admet-276	525	4	2014	2014	NUM
admet-276	525	5	)	)	PUNCT
admet-276	525	6	1843	1843	NUM
admet-276	525	7	-	-	SYM
admet-276	525	8	1857	1857	NUM
admet-276	525	9	.	.	PUNCT
admet-276	526	1	[	[	X
admet-276	526	2	67	67	NUM
admet-276	526	3	]	]	X
admet-276	526	4	y.q	y.q	PROPN
admet-276	526	5	.	.	PROPN
admet-276	526	6	xiao	xiao	PROPN
admet-276	526	7	.	.	PUNCT
admet-276	526	8	moj	moj	PROPN
admet-276	526	9	immunol	immunol	NOUN
admet-276	526	10	.	.	PUNCT
admet-276	527	1	1	1	NUM
admet-276	527	2	(	(	PUNCT
admet-276	527	3	2014	2014	NUM
admet-276	527	4	)	)	PUNCT
admet-276	527	5	4	4	NUM
admet-276	527	6	.	.	PUNCT
admet-276	528	1	[	[	X
admet-276	528	2	68	68	NUM
admet-276	528	3	]	]	PUNCT
admet-276	528	4	quantitation	quantitation	NOUN
admet-276	528	5	of	of	ADP
admet-276	528	6	antibody	antibody	NOUN
admet-276	528	7	-	-	PUNCT
admet-276	528	8	drug	drug	NOUN
admet-276	528	9	conjugates	conjugate	NOUN
admet-276	528	10	,	,	PUNCT
admet-276	528	11	cyros	cyro	NOUN
admet-276	528	12	application	application	NOUN
admet-276	528	13	note	note	NOUN
admet-276	528	14	,	,	PUNCT
admet-276	528	15	d0020478	d0020478	PROPN
admet-276	528	16	.	.	PUNCT
admet-276	529	1	[	[	X
admet-276	529	2	69	69	NUM
admet-276	529	3	]	]	X
admet-276	529	4	a.p	a.p	PROPN
admet-276	529	5	.	.	PROPN
admet-276	529	6	joyce	joyce	PROPN
admet-276	529	7	,	,	PUNCT
admet-276	529	8	m.	m.	PROPN
admet-276	529	9	wang	wang	PROPN
admet-276	529	10	,	,	PUNCT
admet-276	529	11	r.	r.	PROPN
admet-276	529	12	lawrence	lawrence	PROPN
admet-276	529	13	-	-	PUNCT
admet-276	529	14	henderson	henderson	PROPN
admet-276	529	15	r	r	PROPN
admet-276	529	16	,	,	PUNCT
admet-276	529	17	c.	c.	PROPN
admet-276	529	18	filliettaz	filliettaz	PROPN
admet-276	529	19	,	,	PUNCT
admet-276	529	20	s.s	s.s	PROPN
admet-276	529	21	.	.	PROPN
admet-276	529	22	leung	leung	PROPN
admet-276	529	23	,	,	PUNCT
admet-276	529	24	x.	x.	PROPN
admet-276	529	25	xu	xu	PROPN
admet-276	529	26	,	,	PUNCT
admet-276	529	27	d.m	d.m	PROPN
admet-276	529	28	.	.	PUNCT
admet-276	529	29	o’hara	o’hara	NOUN
admet-276	529	30	.	.	PUNCT
admet-276	530	1	pharm	pharm	NOUN
admet-276	530	2	.	.	PUNCT
admet-276	531	1	res	re	NOUN
admet-276	531	2	.	.	PROPN
admet-276	532	1	31	31	NUM
admet-276	532	2	(	(	PUNCT
admet-276	532	3	2014	2014	NUM
admet-276	532	4	)	)	PUNCT
admet-276	532	5	1823	1823	NUM
admet-276	532	6	-	-	SYM
admet-276	532	7	1833	1833	NUM
admet-276	532	8	.	.	PUNCT
admet-276	533	1	[	[	X
admet-276	533	2	70	70	X
admet-276	533	3	]	]	PUNCT
admet-276	533	4	j.	j.	PROPN
admet-276	533	5	h.	h.	PROPN
admet-276	533	6	heo	heo	PROPN
admet-276	533	7	,	,	PUNCT
admet-276	533	8	x.	x.	PROPN
admet-276	533	9	mou	mou	PROPN
admet-276	533	10	,	,	PUNCT
admet-276	533	11	f.	f.	PROPN
admet-276	533	12	wang	wang	PROPN
admet-276	533	13	,	,	PUNCT
admet-276	533	14	j.m	j.m	PROPN
admet-276	533	15	.	.	PROPN
admet-276	533	16	troisi	troisi	PROPN
admet-276	533	17	,	,	PUNCT
admet-276	533	18	c.w	c.w	PROPN
admet-276	533	19	.	.	PROPN
admet-276	533	20	sandifer	sandifer	NOUN
admet-276	533	21	,	,	PUNCT
admet-276	533	22	s.	s.	PROPN
admet-276	533	23	kirby	kirby	PROPN
admet-276	533	24	,	,	PUNCT
admet-276	533	25	d.	d.	PROPN
admet-276	533	26	driscoll	driscoll	PROPN
admet-276	533	27	,	,	PUNCT
admet-276	533	28	s.	s.	PROPN
admet-276	533	29	mercorelli	mercorelli	PROPN
admet-276	533	30	,	,	PUNCT
admet-276	533	31	d.j	d.j	PROPN
admet-276	533	32	.	.	PROPN
admet-276	533	33	pollard	pollard	PROPN
admet-276	533	34	.	.	PUNCT
admet-276	533	35	pharm	pharm	PROPN
admet-276	533	36	.	.	PUNCT
admet-276	534	1	bioprocess	bioprocess	NOUN
admet-276	534	2	.	.	PUNCT
admet-276	535	1	2	2	NUM
admet-276	535	2	(	(	PUNCT
admet-276	535	3	2014	2014	NUM
admet-276	535	4	)	)	PUNCT
admet-276	535	5	129	129	NUM
admet-276	535	6	-	-	SYM
admet-276	535	7	139	139	NUM
admet-276	535	8	.	.	PUNCT
admet-276	536	1	[	[	X
admet-276	536	2	71	71	NUM
admet-276	536	3	]	]	SYM
admet-276	536	4	c.m	c.m	PROPN
admet-276	536	5	.	.	PROPN
admet-276	536	6	hall	hall	PROPN
admet-276	536	7	,	,	PUNCT
admet-276	536	8	j.t	j.t	PROPN
admet-276	536	9	.	.	PROPN
admet-276	536	10	pearson	pearson	PROPN
admet-276	536	11	,	,	PUNCT
admet-276	536	12	v.	v.	PROPN
admet-276	536	13	patel	patel	PROPN
admet-276	536	14	,	,	PUNCT
admet-276	536	15	l.c	l.c	PROPN
admet-276	536	16	.	.	PROPN
admet-276	536	17	wienkers	wienker	NOUN
admet-276	536	18	,	,	PUNCT
admet-276	536	19	r.j	r.j	PROPN
admet-276	536	20	.	.	PROPN
admet-276	536	21	greene	greene	PROPN
admet-276	536	22	.	.	PUNCT
admet-276	537	1	j.	j.	PROPN
admet-276	537	2	immunol	immunol	PROPN
admet-276	537	3	.	.	PUNCT
admet-276	538	1	methods	method	NOUN
admet-276	538	2	393	393	NUM
admet-276	538	3	(	(	PUNCT
admet-276	538	4	2013	2013	NUM
admet-276	538	5	)	)	PUNCT
admet-276	538	6	70	70	NUM
admet-276	538	7	-	-	SYM
admet-276	538	8	73	73	NUM
admet-276	538	9	.	.	PUNCT
admet-276	539	1	[	[	X
admet-276	539	2	72	72	NUM
admet-276	539	3	]	]	X
admet-276	539	4	r.	r.	PROPN
admet-276	539	5	piparia	piparia	PROPN
admet-276	539	6	,	,	PUNCT
admet-276	539	7	d.	d.	PROPN
admet-276	539	8	ouellette	ouellette	PROPN
admet-276	539	9	,	,	PUNCT
admet-276	539	10	w.b	w.b	PROPN
admet-276	539	11	.	.	PROPN
admet-276	539	12	stine	stine	PROPN
admet-276	539	13	,	,	PUNCT
admet-276	539	14	c.	c.	PROPN
admet-276	539	15	grinnell	grinnell	PROPN
admet-276	539	16	,	,	PUNCT
admet-276	539	17	e.	e.	PROPN
admet-276	539	18	tarcsa	tarcsa	PROPN
admet-276	539	19	,	,	PUNCT
admet-276	539	20	c.	c.	PROPN
admet-276	539	21	radziejewski	radziejewski	PROPN
admet-276	539	22	,	,	PUNCT
admet-276	539	23	i.	i.	PROPN
admet-276	539	24	correia	correia	PROPN
admet-276	539	25	.	.	PUNCT
admet-276	540	1	mabs	mabs	PROPN
admet-276	540	2	4	4	NUM
admet-276	540	3	(	(	PUNCT
admet-276	540	4	2012	2012	NUM
admet-276	540	5	)	)	PUNCT
admet-276	540	6	521	521	NUM
admet-276	540	7	-	-	SYM
admet-276	540	8	531	531	NUM
admet-276	540	9	.	.	PUNCT
admet-276	541	1	[	[	X
admet-276	541	2	73	73	NUM
admet-276	541	3	]	]	PUNCT
admet-276	541	4	x.	x.	PROPN
admet-276	541	5	peng	peng	PROPN
admet-276	541	6	,	,	PUNCT
admet-276	541	7	b.	b.	PROPN
admet-276	541	8	liu	liu	PROPN
admet-276	541	9	,	,	PUNCT
admet-276	541	10	y.	y.	PROPN
admet-276	541	11	li	li	PROPN
admet-276	541	12	,	,	PUNCT
admet-276	541	13	h.	h.	PROPN
admet-276	541	14	wang	wang	PROPN
admet-276	541	15	,	,	PUNCT
admet-276	541	16	x.	x.	PROPN
admet-276	541	17	chen	chen	PROPN
admet-276	541	18	,	,	PUNCT
admet-276	541	19	h.	h.	PROPN
admet-276	541	20	guo	guo	PROPN
admet-276	541	21	,	,	PUNCT
admet-276	541	22	q.	q.	PROPN
admet-276	541	23	guo	guo	PROPN
admet-276	541	24	,	,	PUNCT
admet-276	541	25	j.	j.	PROPN
admet-276	541	26	xu	xu	PROPN
admet-276	541	27	,	,	PUNCT
admet-276	541	28	h.	h.	PROPN
admet-276	541	29	wang	wang	PROPN
admet-276	541	30	,	,	PUNCT
admet-276	541	31	d.	d.	PROPN
admet-276	541	32	zhang	zhang	PROPN
admet-276	541	33	,	,	PUNCT
admet-276	541	34	j.	j.	PROPN
admet-276	541	35	dai	dai	PROPN
admet-276	541	36	,	,	PUNCT
admet-276	541	37	s.	s.	PROPN
admet-276	541	38	hou	hou	PROPN
admet-276	541	39	,	,	PUNCT
admet-276	541	40	y.	y.	PROPN
admet-276	541	41	guo	guo	PROPN
admet-276	541	42	.	.	PUNCT
admet-276	541	43	chromatographia	chromatographia	PROPN
admet-276	541	44	78	78	NUM
admet-276	541	45	(	(	PUNCT
admet-276	541	46	2015	2015	NUM
admet-276	541	47	)	)	PUNCT
admet-276	541	48	521	521	NUM
admet-276	541	49	-	-	SYM
admet-276	541	50	531	531	NUM
admet-276	541	51	.	.	PUNCT
admet-276	542	1	[	[	X
admet-276	542	2	74	74	NUM
admet-276	542	3	]	]	X
admet-276	542	4	m.h	m.h	PROPN
admet-276	542	5	.	.	PROPN
admet-276	542	6	park	park	PROPN
admet-276	542	7	,	,	PUNCT
admet-276	542	8	m.w	m.w	PROPN
admet-276	542	9	.	.	PROPN
admet-276	542	10	lee	lee	PROPN
admet-276	542	11	,	,	PUNCT
admet-276	542	12	y.g	y.g	PROPN
admet-276	542	13	.	.	PROPN
admet-276	542	14	shin	shin	PROPN
admet-276	542	15	.	.	PUNCT
admet-276	542	16	biomed	biome	VERB
admet-276	542	17	.	.	PUNCT
admet-276	543	1	chromatogr	chromatogr	NOUN
admet-276	543	2	.	.	PUNCT
admet-276	544	1	2015	2015	NUM
admet-276	544	2	.	.	PUNCT
admet-276	545	1	[	[	X
admet-276	545	2	75	75	NUM
admet-276	545	3	]	]	PUNCT
admet-276	545	4	q.	q.	PROPN
admet-276	545	5	zhang	zhang	PROPN
admet-276	545	6	,	,	PUNCT
admet-276	545	7	d.s	d.s	PROPN
admet-276	545	8	.	.	PROPN
admet-276	545	9	spellman	spellman	PROPN
admet-276	545	10	,	,	PUNCT
admet-276	545	11	y.	y.	PROPN
admet-276	545	12	song	song	PROPN
admet-276	545	13	,	,	PUNCT
admet-276	545	14	b.	b.	PROPN
admet-276	545	15	choi	choi	PROPN
admet-276	545	16	,	,	PUNCT
admet-276	545	17	n.g	n.g	PROPN
admet-276	545	18	.	.	PROPN
admet-276	545	19	hatcher	hatcher	PROPN
admet-276	545	20	,	,	PUNCT
admet-276	545	21	d.	d.	PROPN
admet-276	545	22	tomazela	tomazela	PROPN
admet-276	545	23	,	,	PUNCT
admet-276	545	24	m.	m.	NOUN
admet-276	545	25	beaumont	beaumont	PROPN
admet-276	545	26	,	,	PUNCT
admet-276	545	27	m.	m.	NOUN
admet-276	545	28	tabrizifard	tabrizifard	PROPN
admet-276	545	29	,	,	PUNCT
admet-276	545	30	d.	d.	PROPN
admet-276	545	31	prabhavalkar	prabhavalkar	PROPN
admet-276	545	32	,	,	PUNCT
admet-276	545	33	w.	w.	PROPN
admet-276	545	34	seghezzi	seghezzi	PROPN
admet-276	545	35	,	,	PUNCT
admet-276	545	36	j.	j.	PROPN
admet-276	545	37	harrelson	harrelson	PROPN
admet-276	545	38	,	,	PUNCT
admet-276	545	39	k.p	k.p	PROPN
admet-276	545	40	.	.	PROPN
admet-276	545	41	bateman	bateman	PROPN
admet-276	545	42	.	.	PUNCT
admet-276	545	43	anal	anal	PROPN
admet-276	545	44	.	.	PUNCT
admet-276	546	1	chem	chem	PROPN
admet-276	546	2	.	.	PUNCT
admet-276	547	1	86	86	NUM
admet-276	547	2	(	(	PUNCT
admet-276	547	3	2014	2014	NUM
admet-276	547	4	)	)	PUNCT
admet-276	547	5	8776	8776	NUM
admet-276	547	6	-	-	SYM
admet-276	547	7	8784	8784	NUM
admet-276	547	8	.	.	PUNCT
admet-276	548	1	[	[	X
admet-276	548	2	76	76	NUM
admet-276	548	3	]	]	X
admet-276	548	4	h.	h.	PROPN
admet-276	548	5	li	li	PROPN
admet-276	548	6	,	,	PUNCT
admet-276	548	7	r.	r.	PROPN
admet-276	548	8	ortiz	ortiz	PROPN
admet-276	548	9	,	,	PUNCT
admet-276	548	10	l.	l.	PROPN
admet-276	548	11	tran	tran	PROPN
admet-276	548	12	,	,	PUNCT
admet-276	548	13	m.	m.	NOUN
admet-276	548	14	hall	hall	PROPN
admet-276	548	15	,	,	PUNCT
admet-276	548	16	c.	c.	PROPN
admet-276	548	17	spahr	spahr	PROPN
admet-276	548	18	,	,	PUNCT
admet-276	548	19	k.	k.	PROPN
admet-276	548	20	walker	walker	PROPN
admet-276	548	21	,	,	PUNCT
admet-276	548	22	j.	j.	PROPN
admet-276	548	23	laudemann	laudemann	PROPN
admet-276	548	24	,	,	PUNCT
admet-276	548	25	s.	s.	PROPN
admet-276	548	26	miller	miller	PROPN
admet-276	548	27	,	,	PUNCT
admet-276	548	28	h.	h.	PROPN
admet-276	548	29	salimi	salimi	PROPN
admet-276	548	30	-	-	PUNCT
admet-276	548	31	moosavi	moosavi	NOUN
admet-276	548	32	,	,	PUNCT
admet-276	548	33	j.w	j.w	PROPN
admet-276	548	34	.	.	PROPN
admet-276	548	35	lee	lee	PROPN
admet-276	548	36	.	.	PROPN
admet-276	548	37	anal	anal	PROPN
admet-276	548	38	.	.	PUNCT
admet-276	549	1	chem	chem	PROPN
admet-276	549	2	.	.	PUNCT
admet-276	550	1	84	84	NUM
admet-276	550	2	(	(	PUNCT
admet-276	550	3	2012	2012	NUM
admet-276	550	4	)	)	PUNCT
admet-276	550	5	1267	1267	NUM
admet-276	550	6	-	-	SYM
admet-276	550	7	1273	1273	NUM
admet-276	550	8	.	.	PUNCT
admet-276	551	1	[	[	X
admet-276	551	2	77	77	NUM
admet-276	551	3	]	]	X
admet-276	551	4	a.	a.	NOUN
admet-276	551	5	beck	beck	PROPN
admet-276	551	6	,	,	PUNCT
admet-276	551	7	s.	s.	PROPN
admet-276	551	8	sanglier	sanglier	NOUN
admet-276	551	9	-	-	PUNCT
admet-276	551	10	cianferani	cianferani	NOUN
admet-276	551	11	,	,	PUNCT
admet-276	551	12	a.	a.	PROPN
admet-276	551	13	van	van	PROPN
admet-276	551	14	dorsselaer	dorsselaer	PROPN
admet-276	551	15	.	.	PUNCT
admet-276	552	1	anal	anal	PROPN
admet-276	552	2	.	.	PUNCT
admet-276	552	3	chem	chem	PROPN
admet-276	552	4	.	.	PUNCT
admet-276	553	1	84	84	NUM
admet-276	553	2	(	(	PUNCT
admet-276	553	3	2012	2012	NUM
admet-276	553	4	)	)	PUNCT
admet-276	553	5	4637	4637	NUM
admet-276	553	6	-	-	SYM
admet-276	553	7	4646	4646	NUM
admet-276	553	8	.	.	PUNCT
admet-276	554	1	[	[	X
admet-276	554	2	78	78	NUM
admet-276	554	3	]	]	PUNCT
admet-276	554	4	h.	h.	PROPN
admet-276	554	5	jiang	jiang	PROPN
admet-276	554	6	,	,	PUNCT
admet-276	554	7	j.	j.	PROPN
admet-276	554	8	zeng	zeng	PROPN
admet-276	554	9	,	,	PUNCT
admet-276	554	10	c.	c.	PROPN
admet-276	554	11	titsch	titsch	PROPN
admet-276	554	12	,	,	PUNCT
admet-276	554	13	k.	k.	PROPN
admet-276	554	14	voronin	voronin	PROPN
admet-276	554	15	,	,	PUNCT
admet-276	554	16	b.	b.	PROPN
admet-276	554	17	akinsanya	akinsanya	PROPN
admet-276	554	18	,	,	PUNCT
admet-276	554	19	l.	l.	PROPN
admet-276	554	20	luo	luo	PROPN
admet-276	554	21	,	,	PUNCT
admet-276	554	22	h.	h.	PROPN
admet-276	554	23	shen	shen	PROPN
admet-276	554	24	,	,	PUNCT
admet-276	554	25	d.d	d.d	PROPN
admet-276	554	26	.	.	PROPN
admet-276	554	27	desai	desai	PROPN
admet-276	554	28	,	,	PUNCT
admet-276	554	29	a.	a.	NOUN
admet-276	554	30	allentoff	allentoff	NOUN
admet-276	554	31	,	,	PUNCT
admet-276	554	32	a.f	a.f	PROPN
admet-276	554	33	.	.	PROPN
admet-276	554	34	aubry	aubry	PROPN
admet-276	554	35	,	,	PUNCT
admet-276	554	36	b.s	b.s	PROPN
admet-276	554	37	.	.	PROPN
admet-276	554	38	desilva	desilva	PROPN
admet-276	554	39	,	,	PUNCT
admet-276	554	40	m.e	m.e	PROPN
admet-276	554	41	.	.	PROPN
admet-276	554	42	arnold	arnold	PROPN
admet-276	554	43	.	.	PUNCT
admet-276	555	1	anal	anal	PROPN
admet-276	555	2	.	.	PUNCT
admet-276	555	3	chem	chem	PROPN
admet-276	555	4	.	.	PUNCT
admet-276	556	1	85	85	NUM
admet-276	556	2	(	(	PUNCT
admet-276	556	3	2013	2013	NUM
admet-276	556	4	)	)	PUNCT
admet-276	556	5	9859	9859	NUM
admet-276	556	6	-	-	SYM
admet-276	556	7	9867	9867	NUM
admet-276	556	8	.	.	PUNCT
admet-276	557	1	[	[	X
admet-276	557	2	79	79	NUM
admet-276	557	3	]	]	PUNCT
admet-276	557	4	k.	k.	PROPN
admet-276	557	5	xu	xu	PROPN
admet-276	557	6	,	,	PUNCT
admet-276	557	7	l.	l.	PROPN
admet-276	557	8	liu	liu	PROPN
admet-276	557	9	,	,	PUNCT
admet-276	557	10	m.	m.	PROPN
admet-276	557	11	maia	maia	PROPN
admet-276	557	12	,	,	PUNCT
admet-276	557	13	j.	j.	PROPN
admet-276	557	14	li	li	PROPN
admet-276	557	15	,	,	PUNCT
admet-276	557	16	j.	j.	PROPN
admet-276	557	17	lowe	lowe	PROPN
admet-276	557	18	,	,	PUNCT
admet-276	557	19	a.	a.	NOUN
admet-276	557	20	song	song	NOUN
admet-276	557	21	,	,	PUNCT
admet-276	557	22	s.	s.	PROPN
admet-276	557	23	kaur	kaur	PROPN
admet-276	557	24	.	.	PUNCT
admet-276	558	1	bioanalysis	bioanalysis	NOUN
admet-276	558	2	6	6	NUM
admet-276	558	3	(	(	PUNCT
admet-276	558	4	2014	2014	NUM
admet-276	558	5	)	)	PUNCT
admet-276	558	6	1781	1781	NUM
admet-276	558	7	-	-	SYM
admet-276	558	8	1794	1794	NUM
admet-276	558	9	.	.	PUNCT
admet-276	559	1	[	[	X
admet-276	559	2	80	80	NUM
admet-276	559	3	]	]	X
admet-276	559	4	d.	d.	PROPN
admet-276	559	5	lebert	lebert	PROPN
admet-276	559	6	,	,	PUNCT
admet-276	559	7	g.	g.	PROPN
admet-276	559	8	picard	picard	PROPN
admet-276	559	9	,	,	PUNCT
admet-276	559	10	c	c	X
admet-276	559	11	,	,	PUNCT
admet-276	559	12	beau	beau	NOUN
admet-276	559	13	-	-	PUNCT
admet-276	559	14	larvor	larvor	NOUN
admet-276	559	15	,	,	PUNCT
admet-276	559	16	l.	l.	PROPN
admet-276	559	17	troncy	troncy	PROPN
admet-276	559	18	,	,	PUNCT
admet-276	559	19	c.	c.	PROPN
admet-276	559	20	lacheny	lacheny	PROPN
admet-276	559	21	,	,	PUNCT
admet-276	559	22	b.	b.	PROPN
admet-276	559	23	maynadier	maynadier	PROPN
admet-276	559	24	,	,	PUNCT
admet-276	559	25	w.	w.	PROPN
admet-276	559	26	low	low	PROPN
admet-276	559	27	,	,	PUNCT
admet-276	559	28	n.	n.	NOUN
admet-276	559	29	mouz	mouz	NOUN
admet-276	559	30	,	,	PUNCT
admet-276	559	31	v.	v.	X
admet-276	559	32	brun	brun	PROPN
admet-276	559	33	,	,	PUNCT
admet-276	559	34	c.	c.	PROPN
admet-276	559	35	klinguer	klinguer	PROPN
admet-276	559	36	-	-	PUNCT
admet-276	559	37	hamour	hamour	PROPN
admet-276	559	38	,	,	PUNCT
admet-276	559	39	m.	m.	NOUN
admet-276	559	40	jaquinod	jaquinod	PROPN
admet-276	559	41	,	,	PUNCT
admet-276	559	42	a.	a.	PROPN
admet-276	559	43	beck	beck	PROPN
admet-276	559	44	.	.	PUNCT
admet-276	560	1	bioanalysis	bioanalysis	NOUN
admet-276	560	2	7	7	NUM
admet-276	560	3	(	(	PUNCT
admet-276	560	4	2015	2015	NUM
admet-276	560	5	)	)	PUNCT
admet-276	560	6	1237	1237	NUM
admet-276	560	7	-	-	SYM
admet-276	560	8	1251	1251	NUM
admet-276	560	9	.	.	PUNCT
admet-276	561	1	[	[	X
admet-276	561	2	81	81	NUM
admet-276	561	3	]	]	PUNCT
admet-276	561	4	i.	i.	NOUN
admet-276	561	5	onami	onami	PROPN
admet-276	561	6	,	,	PUNCT
admet-276	561	7	m.	m.	NOUN
admet-276	561	8	ayabe	ayabe	ADV
admet-276	561	9	,	,	PUNCT
admet-276	561	10	n.	n.	PROPN
admet-276	561	11	murao	murao	NOUN
admet-276	561	12	,	,	PUNCT
admet-276	561	13	m.	m.	NOUN
admet-276	561	14	ishigai	ishigai	PROPN
admet-276	561	15	.	.	PUNCT
admet-276	562	1	j.	j.	PROPN
admet-276	562	2	chromatogr	chromatogr	PROPN
admet-276	562	3	.	.	PUNCT
admet-276	563	1	a	a	DET
admet-276	563	2	1334	1334	NUM
admet-276	563	3	(	(	PUNCT
admet-276	563	4	2014	2014	NUM
admet-276	563	5	)	)	PUNCT
admet-276	563	6	64	64	NUM
admet-276	563	7	-	-	SYM
admet-276	563	8	71	71	NUM
admet-276	563	9	.	.	PUNCT
admet-276	564	1	[	[	X
admet-276	564	2	82	82	NUM
admet-276	564	3	]	]	X
admet-276	564	4	k.	k.	PROPN
admet-276	564	5	sandra	sandra	PROPN
admet-276	564	6	,	,	PUNCT
admet-276	564	7	p.	p.	PROPN
admet-276	564	8	sandra	sandra	PROPN
admet-276	564	9	.	.	PUNCT
admet-276	565	1	bioanalysis	bioanalysis	PROPN
admet-276	565	2	7	7	NUM
admet-276	565	3	(	(	PUNCT
admet-276	565	4	2015	2015	NUM
admet-276	565	5	)	)	PUNCT
admet-276	565	6	2843	2843	NUM
admet-276	565	7	-	-	SYM
admet-276	565	8	2847	2847	NUM
admet-276	565	9	.	.	PUNCT
admet-276	566	1	[	[	X
admet-276	566	2	83	83	NUM
admet-276	566	3	]	]	PUNCT
admet-276	566	4	s.	s.	PROPN
admet-276	566	5	rosati	rosati	PROPN
admet-276	566	6	,	,	PUNCT
admet-276	566	7	y.	y.	PROPN
admet-276	566	8	yang	yang	PROPN
admet-276	566	9	,	,	PUNCT
admet-276	566	10	a.	a.	NOUN
admet-276	566	11	barendregt	barendregt	PROPN
admet-276	566	12	,	,	PUNCT
admet-276	566	13	a.j.r	a.j.r	NOUN
admet-276	566	14	.	.	PUNCT
admet-276	566	15	heck	heck	INTJ
admet-276	566	16	.	.	PUNCT
admet-276	567	1	nat	nat	PROPN
admet-276	567	2	.	.	PUNCT
admet-276	568	1	protoc	protoc	VERB
admet-276	568	2	.	.	PUNCT
admet-276	569	1	9	9	NUM
admet-276	569	2	(	(	PUNCT
admet-276	569	3	2014	2014	NUM
admet-276	569	4	)	)	PUNCT
admet-276	569	5	967	967	NUM
admet-276	569	6	-	-	SYM
admet-276	569	7	976	976	NUM
admet-276	569	8	.	.	PUNCT
admet-276	570	1	[	[	X
admet-276	570	2	84	84	NUM
admet-276	570	3	]	]	X
admet-276	570	4	m.t	m.t	PROPN
admet-276	570	5	.	.	PROPN
admet-276	570	6	furlong	furlong	PROPN
admet-276	570	7	,	,	PUNCT
admet-276	570	8	s.	s.	PROPN
admet-276	570	9	zhao	zhao	PROPN
admet-276	570	10	,	,	PUNCT
admet-276	570	11	w.	w.	PROPN
admet-276	570	12	mylott	mylott	PROPN
admet-276	570	13	,	,	PUNCT
admet-276	570	14	r.	r.	PROPN
admet-276	570	15	jenkins	jenkins	PROPN
admet-276	570	16	,	,	PUNCT
admet-276	570	17	m.	m.	NOUN
admet-276	570	18	gao	gao	PROPN
admet-276	570	19	,	,	PUNCT
admet-276	570	20	v.	v.	X
admet-276	570	21	hegde	hegde	PROPN
admet-276	570	22	,	,	PUNCT
admet-276	570	23	j.	j.	PROPN
admet-276	570	24	tamura	tamura	PROPN
admet-276	570	25	,	,	PUNCT
admet-276	570	26	a.	a.	PROPN
admet-276	570	27	tymiak	tymiak	PROPN
admet-276	570	28	,	,	PUNCT
admet-276	570	29	m.	m.	NOUN
admet-276	570	30	jemal	jemal	NOUN
admet-276	570	31	.	.	PUNCT
admet-276	571	1	bioanalysis	bioanalysis	NOUN
admet-276	571	2	5	5	NUM
admet-276	571	3	(	(	PUNCT
admet-276	571	4	2013	2013	NUM
admet-276	571	5	)	)	PUNCT
admet-276	571	6	1363	1363	NUM
admet-276	571	7	-	-	SYM
admet-276	571	8	1376	1376	NUM
admet-276	571	9	.	.	PUNCT
admet-276	572	1	[	[	X
admet-276	572	2	85	85	NUM
admet-276	572	3	]	]	PUNCT
admet-276	572	4	a.	a.	NOUN
admet-276	572	5	liu	liu	PROPN
admet-276	572	6	,	,	PUNCT
admet-276	572	7	a.	a.	PROPN
admet-276	572	8	kozhich	kozhich	PROPN
admet-276	572	9	,	,	PUNCT
admet-276	572	10	d.	d.	PROPN
admet-276	572	11	passmore	passmore	PROPN
admet-276	572	12	,	,	PUNCT
admet-276	572	13	h.	h.	PROPN
admet-276	572	14	gu	gu	PROPN
admet-276	572	15	,	,	PUNCT
admet-276	572	16	r.	r.	PROPN
admet-276	572	17	wong	wong	PROPN
admet-276	572	18	,	,	PUNCT
admet-276	572	19	f.	f.	PROPN
admet-276	572	20	zambito	zambito	PROPN
admet-276	572	21	,	,	PUNCT
admet-276	572	22	v.s.	v.s.	ADJ
admet-276	572	23	rangan	rangan	PROPN
admet-276	572	24	,	,	PUNCT
admet-276	572	25	h.	h.	PROPN
admet-276	572	26	myler	myler	PROPN
admet-276	572	27	,	,	PUNCT
admet-276	572	28	a.f	a.f	PROPN
admet-276	572	29	.	.	PROPN
admet-276	572	30	aubry	aubry	PROPN
admet-276	572	31	,	,	PUNCT
admet-276	572	32	m.e	m.e	PROPN
admet-276	572	33	.	.	PROPN
admet-276	572	34	arnold	arnold	PROPN
admet-276	572	35	,	,	PUNCT
admet-276	572	36	j.	j.	PROPN
admet-276	572	37	wang	wang	PROPN
admet-276	572	38	.	.	PUNCT
admet-276	573	1	j.	j.	PROPN
admet-276	573	2	chromatogr	chromatogr	PROPN
admet-276	573	3	.	.	PUNCT
admet-276	574	1	b	b	PROPN
admet-276	574	2	analyt	analyt	ADJ
admet-276	574	3	.	.	PUNCT
admet-276	575	1	technol	technol	PROPN
admet-276	575	2	.	.	PROPN
admet-276	575	3	biomed	biome	VERB
admet-276	575	4	.	.	PUNCT
admet-276	576	1	life	life	PROPN
admet-276	576	2	sci	sci	PROPN
admet-276	576	3	.	.	PROPN
admet-276	576	4	1002	1002	NUM
admet-276	576	5	(	(	PUNCT
admet-276	576	6	2015	2015	NUM
admet-276	576	7	)	)	PUNCT
admet-276	576	8	54	54	NUM
admet-276	576	9	-	-	SYM
admet-276	576	10	62	62	NUM
admet-276	576	11	.	.	PUNCT
admet-276	577	1	[	[	X
admet-276	577	2	86	86	NUM
admet-276	577	3	]	]	X
admet-276	577	4	r.m	r.m	PROPN
admet-276	577	5	.	.	PROPN
admet-276	577	6	crisino	crisino	PROPN
admet-276	577	7	,	,	PUNCT
admet-276	577	8	l.	l.	PROPN
admet-276	577	9	luo	luo	PROPN
admet-276	577	10	,	,	PUNCT
admet-276	577	11	b.	b.	PROPN
admet-276	577	12	geist	geist	PROPN
admet-276	577	13	,	,	PUNCT
admet-276	577	14	j.	j.	PROPN
admet-276	577	15	zoghbi	zoghbi	PROPN
admet-276	577	16	,	,	PUNCT
admet-276	577	17	f.	f.	PROPN
admet-276	577	18	spriggs	spriggs	PROPN
admet-276	577	19	.	.	PUNCT
admet-276	578	1	bioanalysis	bioanalysis	NOUN
admet-276	578	2	6	6	NUM
admet-276	578	3	(	(	PUNCT
admet-276	578	4	2014	2014	NUM
admet-276	578	5	)	)	PUNCT
admet-276	578	6	1033	1033	NUM
admet-276	578	7	-	-	SYM
admet-276	578	8	1036	1036	NUM
admet-276	578	9	.	.	PUNCT
admet-276	579	1	[	[	X
admet-276	579	2	87	87	NUM
admet-276	579	3	]	]	PUNCT
admet-276	579	4	j.	j.	PROPN
admet-276	579	5	zoghbi	zoghbi	PROPN
admet-276	579	6	,	,	PUNCT
admet-276	579	7	y.	y.	PROPN
admet-276	579	8	xu	xu	PROPN
admet-276	579	9	,	,	PUNCT
admet-276	579	10	r.	r.	PROPN
admet-276	579	11	grabert	grabert	PROPN
admet-276	579	12	,	,	PUNCT
admet-276	579	13	v.	v.	ADP
admet-276	579	14	theobald	theobald	NOUN
admet-276	579	15	,	,	PUNCT
admet-276	579	16	s.	s.	PROPN
admet-276	579	17	richards	richards	PROPN
admet-276	579	18	.	.	PUNCT
admet-276	580	1	j.	j.	PROPN
admet-276	580	2	immunol	immunol	PROPN
admet-276	580	3	.	.	PUNCT
admet-276	581	1	methods	method	NOUN
admet-276	581	2	426	426	NUM
admet-276	581	3	(	(	PUNCT
admet-276	581	4	2015	2015	NUM
admet-276	581	5	)	)	PUNCT
admet-276	581	6	62	62	NUM
admet-276	581	7	-	-	SYM
admet-276	581	8	69	69	NUM
admet-276	581	9	.	.	PUNCT
admet-276	582	1	[	[	X
admet-276	582	2	88	88	NUM
admet-276	582	3	]	]	X
admet-276	582	4	fda	fda	PROPN
admet-276	582	5	.	.	PUNCT
admet-276	582	6	guidance	guidance	NOUN
admet-276	582	7	for	for	ADP
admet-276	582	8	industry	industry	NOUN
admet-276	582	9	:	:	PUNCT
admet-276	582	10	nonclinical	nonclinical	ADJ
admet-276	582	11	studies	study	NOUN
admet-276	582	12	for	for	ADP
admet-276	582	13	the	the	DET
admet-276	582	14	safety	safety	NOUN
admet-276	582	15	evaluation	evaluation	NOUN
admet-276	582	16	of	of	ADP
admet-276	582	17	pharmaceutical	pharmaceutical	NOUN
admet-276	582	18	excipients	excipient	NOUN
admet-276	582	19	.	.	PUNCT
admet-276	583	1	(	(	PUNCT
admet-276	583	2	2005	2005	NUM
admet-276	583	3	)	)	PUNCT
admet-276	583	4	available	available	ADJ
admet-276	583	5	from	from	ADP
admet-276	583	6	:	:	PUNCT
admet-276	583	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	PROPN
admet-276	583	8	9250.pdf	9250.pdf	NOUN
admet-276	583	9	.	.	PUNCT
admet-276	584	1	(	(	PUNCT
admet-276	584	2	accessed	access	VERB
admet-276	584	3	on	on	ADP
admet-276	584	4	march	march	PROPN
admet-276	584	5	23	23	NUM
admet-276	584	6	,	,	PUNCT
admet-276	584	7	2016	2016	NUM
admet-276	584	8	)	)	PUNCT
admet-276	584	9	.	.	PUNCT
admet-276	585	1	[	[	X
admet-276	585	2	89	89	NUM
admet-276	585	3	]	]	X
admet-276	585	4	fda	fda	PROPN
admet-276	585	5	.	.	PUNCT
admet-276	585	6	guidance	guidance	NOUN
admet-276	585	7	for	for	ADP
admet-276	585	8	industry	industry	NOUN
admet-276	585	9	:	:	PUNCT
admet-276	585	10	bioanalytical	bioanalytical	ADJ
admet-276	585	11	method	method	NOUN
admet-276	585	12	validation	validation	NOUN
admet-276	585	13	,	,	PUNCT
admet-276	585	14	biopharmaceutics	biopharmaceutics	NOUN
admet-276	585	15	.	.	PUNCT
admet-276	586	1	revision	revision	NOUN
admet-276	586	2	1	1	NUM
admet-276	586	3	.	.	PUNCT
admet-276	587	1	(	(	PUNCT
admet-276	587	2	2013	2013	NUM
admet-276	587	3	)	)	PUNCT
admet-276	587	4	available	available	ADJ
admet-276	587	5	from	from	ADP
admet-276	587	6	:	:	PUNCT
admet-276	587	7	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm	NUM
admet-276	587	8	368107.pdf	368107.pdf	NUM
admet-276	587	9	.	.	PUNCT
admet-276	588	1	(	(	PUNCT
admet-276	588	2	accessed	access	VERB
admet-276	588	3	on	on	ADP
admet-276	588	4	march	march	PROPN
admet-276	588	5	23	23	NUM
admet-276	588	6	,	,	PUNCT
admet-276	588	7	2016	2016	NUM
admet-276	588	8	)	)	PUNCT
admet-276	588	9	.	.	PUNCT
admet-276	589	1	admet	admet	PROPN
admet-276	589	2	&	&	CCONJ
admet-276	589	3	dmpk	dmpk	PROPN
admet-276	589	4	4(1	4(1	NOUN
admet-276	589	5	)	)	PUNCT
admet-276	589	6	(	(	PUNCT
admet-276	589	7	2016	2016	NUM
admet-276	589	8	)	)	PUNCT
admet-276	589	9	1	1	NUM
admet-276	589	10	-	-	SYM
admet-276	589	11	22	22	NUM
admet-276	589	12	adme	adme	NOUN
admet-276	589	13	testing	testing	NOUN
admet-276	589	14	of	of	ADP
admet-276	589	15	large	large	ADJ
admet-276	589	16	biologics	biologic	NOUN
admet-276	589	17	doi	doi	NOUN
admet-276	589	18	:	:	PUNCT
admet-276	589	19	10.5599	10.5599	NUM
admet-276	589	20	/	/	SYM
admet-276	589	21	admet.4.1.276	admet.4.1.276	NUM
admet-276	589	22	21	21	NUM
admet-276	590	1	[	[	X
admet-276	590	2	90	90	NUM
admet-276	590	3	]	]	X
admet-276	590	4	k.l	k.l	PROPN
admet-276	590	5	.	.	PROPN
admet-276	590	6	hastings	hastings	PROPN
admet-276	590	7	,	,	PUNCT
admet-276	590	8	int	int	PROPN
admet-276	590	9	.	.	PUNCT
admet-276	591	1	immunopharmacol	immunopharmacol	PROPN
admet-276	591	2	.	.	PROPN
admet-276	591	3	2	2	NUM
admet-276	591	4	(	(	PUNCT
admet-276	591	5	2002	2002	NUM
admet-276	591	6	)	)	PUNCT
admet-276	591	7	1613	1613	NUM
admet-276	591	8	-	-	SYM
admet-276	591	9	1618	1618	NUM
admet-276	591	10	.	.	PUNCT
admet-276	592	1	[	[	X
admet-276	592	2	91	91	NUM
admet-276	592	3	]	]	PUNCT
admet-276	592	4	k.	k.	PROPN
admet-276	592	5	seitz	seitz	PROPN
admet-276	592	6	,	,	PUNCT
admet-276	592	7	h.	h.	PROPN
admet-276	592	8	zhou	zhou	PROPN
admet-276	592	9	.	.	PUNCT
admet-276	593	1	j.	j.	PROPN
admet-276	593	2	clin	clin	PROPN
admet-276	593	3	.	.	PUNCT
admet-276	594	1	pharmacol	pharmacol	PROPN
admet-276	594	2	.	.	PUNCT
admet-276	595	1	47	47	NUM
admet-276	595	2	(	(	PUNCT
admet-276	595	3	2007	2007	NUM
admet-276	595	4	)	)	PUNCT
admet-276	595	5	1104	1104	NUM
admet-276	595	6	-	-	SYM
admet-276	595	7	1118	1118	NUM
admet-276	595	8	.	.	PUNCT
admet-276	596	1	[	[	X
admet-276	596	2	92	92	NUM
admet-276	596	3	]	]	SYM
admet-276	596	4	ich	ich	NOUN
admet-276	596	5	.	.	PUNCT
admet-276	596	6	guidance	guidance	NOUN
admet-276	596	7	for	for	ADP
admet-276	596	8	industry	industry	NOUN
admet-276	596	9	:	:	PUNCT
admet-276	596	10	q3b(r2	q3b(r2	NOUN
admet-276	596	11	)	)	PUNCT
admet-276	596	12	impurities	impurity	NOUN
admet-276	596	13	in	in	ADP
admet-276	596	14	new	new	ADJ
admet-276	596	15	drug	drug	NOUN
admet-276	596	16	products.2006	products.2006	PROPN
admet-276	596	17	.	.	PUNCT
admet-276	596	18	available	available	ADJ
admet-276	596	19	from	from	ADP
admet-276	596	20	:	:	PUNCT
admet-276	596	21	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	PROPN
admet-276	596	22	3389.pdf	3389.pdf	NOUN
admet-276	596	23	.	.	PUNCT
admet-276	597	1	(	(	PUNCT
admet-276	597	2	accessed	access	VERB
admet-276	597	3	on	on	ADP
admet-276	597	4	march	march	PROPN
admet-276	597	5	23	23	NUM
admet-276	597	6	,	,	PUNCT
admet-276	597	7	2016	2016	NUM
admet-276	597	8	)	)	PUNCT
admet-276	597	9	.	.	PUNCT
admet-276	598	1	[	[	X
admet-276	598	2	93	93	NUM
admet-276	598	3	]	]	PUNCT
admet-276	598	4	ich	ich	NOUN
admet-276	598	5	.	.	PUNCT
admet-276	599	1	guidance	guidance	NOUN
admet-276	599	2	for	for	ADP
admet-276	599	3	industry	industry	NOUN
admet-276	599	4	:	:	PUNCT
admet-276	599	5	q3a	q3a	PROPN
admet-276	599	6	impurities	impuritie	VERB
admet-276	599	7	in	in	ADP
admet-276	599	8	new	new	ADJ
admet-276	599	9	drug	drug	PROPN
admet-276	599	10	substances.2008	substances.2008	PROPN
admet-276	599	11	.	.	PROPN
admet-276	599	12	available	available	ADJ
admet-276	599	13	from	from	ADP
admet-276	599	14	:	:	PUNCT
admet-276	599	15	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm07	PROPN
admet-276	599	16	3385.pdf	3385.pdf	NOUN
admet-276	599	17	.	.	PUNCT
admet-276	600	1	(	(	PUNCT
admet-276	600	2	accessed	access	VERB
admet-276	600	3	on	on	ADP
admet-276	600	4	march	march	PROPN
admet-276	600	5	23	23	NUM
admet-276	600	6	,	,	PUNCT
admet-276	600	7	2016	2016	NUM
admet-276	600	8	)	)	PUNCT
admet-276	600	9	.	.	PUNCT
admet-276	601	1	[	[	X
admet-276	601	2	94	94	NUM
admet-276	601	3	]	]	X
admet-276	601	4	regulatory	regulatory	ADJ
admet-276	601	5	considerations	consideration	NOUN
admet-276	601	6	for	for	ADP
admet-276	601	7	antibody	antibody	NOUN
admet-276	601	8	-	-	PUNCT
admet-276	601	9	drug	drug	NOUN
admet-276	601	10	conjugates	conjugate	NOUN
admet-276	601	11	,	,	PUNCT
admet-276	601	12	ops	op	NOUN
admet-276	601	13	,	,	PUNCT
admet-276	601	14	cder	cder	NOUN
admet-276	601	15	,	,	PUNCT
admet-276	601	16	aaps	aap	NOUN
admet-276	601	17	(	(	PUNCT
admet-276	601	18	october	october	PROPN
admet-276	601	19	18	18	NUM
admet-276	601	20	,	,	PUNCT
admet-276	601	21	2012	2012	NUM
admet-276	601	22	)	)	PUNCT
admet-276	601	23	.	.	PUNCT
admet-276	602	1	available	available	ADJ
admet-276	602	2	from	from	ADP
admet-276	602	3	:	:	PUNCT
admet-276	602	4	http://www.fda.gov/downloads/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/	http://www.fda.gov/downloads/aboutfda/centersoffices/officeofmedicalproductsandtobacco/cder/	PROPN
admet-276	602	5	ucm341177.pdf	ucm341177.pdf	NOUN
admet-276	602	6	.	.	PUNCT
admet-276	603	1	(	(	PUNCT
admet-276	603	2	accessed	access	VERB
admet-276	603	3	on	on	ADP
admet-276	603	4	march	march	PROPN
admet-276	603	5	23	23	NUM
admet-276	603	6	,	,	PUNCT
admet-276	603	7	2016	2016	NUM
admet-276	603	8	)	)	PUNCT
admet-276	603	9	.	.	PUNCT
admet-276	604	1	[	[	X
admet-276	604	2	95	95	NUM
admet-276	604	3	]	]	PUNCT
admet-276	604	4	i.	i.	PROPN
admet-276	604	5	mahmood	mahmood	PROPN
admet-276	604	6	.	.	PUNCT
admet-276	605	1	clin	clin	PROPN
admet-276	605	2	.	.	PUNCT
admet-276	605	3	pharmacokinet	pharmacokinet	PROPN
admet-276	605	4	.	.	PUNCT
admet-276	606	1	51	51	NUM
admet-276	606	2	(	(	PUNCT
admet-276	606	3	2012	2012	NUM
admet-276	606	4	)	)	PUNCT
admet-276	606	5	527	527	NUM
admet-276	606	6	-	-	SYM
admet-276	606	7	542	542	NUM
admet-276	606	8	.	.	PUNCT
admet-276	607	1	[	[	X
admet-276	607	2	96	96	NUM
admet-276	607	3	]	]	X
admet-276	607	4	h.	h.	PROPN
admet-276	607	5	wan	wan	PROPN
admet-276	607	6	,	,	PUNCT
admet-276	607	7	p.	p.	PROPN
admet-276	607	8	bold	bold	PROPN
admet-276	607	9	,	,	PUNCT
admet-276	607	10	l.o	l.o	PROPN
admet-276	607	11	.	.	PROPN
admet-276	607	12	larsson	larsson	PROPN
admet-276	607	13	,	,	PUNCT
admet-276	607	14	j.	j.	PROPN
admet-276	607	15	ulander	ulander	PROPN
admet-276	607	16	,	,	PUNCT
admet-276	607	17	s.	s.	PROPN
admet-276	607	18	peters	peters	PROPN
admet-276	607	19	,	,	PUNCT
admet-276	607	20	b.	b.	PROPN
admet-276	607	21	lofberg	lofberg	PROPN
admet-276	607	22	,	,	PUNCT
admet-276	607	23	a.l	a.l	PROPN
admet-276	607	24	.	.	NOUN
admet-276	607	25	ungell	ungell	PROPN
admet-276	607	26	,	,	PUNCT
admet-276	607	27	m.	m.	NOUN
admet-276	607	28	nagard	nagard	PROPN
admet-276	607	29	,	,	PUNCT
admet-276	607	30	a.	a.	NOUN
admet-276	607	31	llinas	llinas	PROPN
admet-276	607	32	.	.	PUNCT
admet-276	608	1	curr	curr	PROPN
admet-276	608	2	.	.	PUNCT
admet-276	608	3	drug	drug	PROPN
admet-276	608	4	metab	metab	NOUN
admet-276	608	5	.	.	PUNCT
admet-276	609	1	11	11	NUM
admet-276	609	2	(	(	PUNCT
admet-276	609	3	2010	2010	NUM
admet-276	609	4	)	)	PUNCT
admet-276	609	5	583	583	NUM
admet-276	609	6	-	-	SYM
admet-276	609	7	594	594	NUM
admet-276	609	8	.	.	PUNCT
admet-276	610	1	[	[	X
admet-276	610	2	97	97	NUM
admet-276	610	3	]	]	X
admet-276	610	4	v.k	v.k	PROPN
admet-276	610	5	.	.	PROPN
admet-276	610	6	sinha	sinha	PROPN
admet-276	610	7	,	,	PUNCT
admet-276	610	8	s.s	s.s	PROPN
admet-276	610	9	.	.	PROPN
admet-276	610	10	de	de	PROPN
admet-276	610	11	buck	buck	PROPN
admet-276	610	12	,	,	PUNCT
admet-276	610	13	l.a	l.a	PROPN
admet-276	610	14	.	.	PROPN
admet-276	610	15	fenu	fenu	PROPN
admet-276	610	16	,	,	PUNCT
admet-276	610	17	j.w	j.w	PROPN
admet-276	610	18	.	.	PROPN
admet-276	610	19	smit	smit	PROPN
admet-276	610	20	,	,	PUNCT
admet-276	610	21	m.	m.	NOUN
admet-276	610	22	nijsen	nijsen	PROPN
admet-276	610	23	,	,	PUNCT
admet-276	610	24	r.a.h.j	r.a.h.j	PROPN
admet-276	610	25	.	.	PROPN
admet-276	610	26	gilissen	gilissen	PROPN
admet-276	610	27	,	,	PUNCT
admet-276	610	28	a.	a.	PROPN
admet-276	610	29	van	van	PROPN
admet-276	610	30	peer	peer	PROPN
admet-276	610	31	,	,	PUNCT
admet-276	610	32	k.	k.	PROPN
admet-276	610	33	lavrijsen	lavrijsen	PROPN
admet-276	610	34	,	,	PUNCT
admet-276	610	35	c.e	c.e	PROPN
admet-276	610	36	.	.	PROPN
admet-276	610	37	mackie	mackie	PROPN
admet-276	610	38	.	.	PUNCT
admet-276	611	1	clin	clin	PROPN
admet-276	611	2	.	.	PUNCT
admet-276	611	3	pharmacokinet	pharmacokinet	PROPN
admet-276	611	4	.	.	PUNCT
admet-276	612	1	47	47	NUM
admet-276	612	2	(	(	PUNCT
admet-276	612	3	2008	2008	NUM
admet-276	612	4	)	)	PUNCT
admet-276	612	5	35	35	NUM
admet-276	612	6	-	-	SYM
admet-276	612	7	45	45	NUM
admet-276	612	8	.	.	PUNCT
admet-276	613	1	[	[	X
admet-276	613	2	98	98	NUM
admet-276	613	3	]	]	X
admet-276	613	4	q.	q.	PROPN
admet-276	613	5	huang	huang	PROPN
admet-276	613	6	,	,	PUNCT
admet-276	613	7	j.e	j.e	PROPN
admet-276	613	8	.	.	PROPN
admet-276	613	9	riviere	riviere	PROPN
admet-276	613	10	.	.	PUNCT
admet-276	614	1	expert	expert	NOUN
admet-276	614	2	opin	opin	NOUN
admet-276	614	3	.	.	PUNCT
admet-276	615	1	drug	drug	NOUN
admet-276	615	2	metab	metab	NOUN
admet-276	615	3	.	.	PUNCT
admet-276	616	1	toxicol	toxicol	PROPN
admet-276	616	2	.	.	PUNCT
admet-276	617	1	10	10	NUM
admet-276	617	2	(	(	PUNCT
admet-276	617	3	2014	2014	NUM
admet-276	617	4	)	)	PUNCT
admet-276	617	5	1241	1241	NUM
admet-276	617	6	-	-	SYM
admet-276	617	7	1253	1253	NUM
admet-276	617	8	.	.	PUNCT
admet-276	618	1	[	[	X
admet-276	618	2	99	99	NUM
admet-276	618	3	]	]	X
admet-276	618	4	l.	l.	PROPN
admet-276	618	5	liu	liu	PROPN
admet-276	618	6	,	,	PUNCT
admet-276	618	7	k.s	k.s	PROPN
admet-276	618	8	.	.	PROPN
admet-276	618	9	pang	pang	PROPN
admet-276	618	10	.	.	PUNCT
admet-276	619	1	eur	eur	PROPN
admet-276	619	2	.	.	PUNCT
admet-276	620	1	j.	j.	PROPN
admet-276	620	2	pharm	pharm	PROPN
admet-276	620	3	.	.	PUNCT
admet-276	621	1	sci	sci	PROPN
admet-276	621	2	.	.	PROPN
admet-276	621	3	29	29	NUM
admet-276	621	4	(	(	PUNCT
admet-276	621	5	2006	2006	NUM
admet-276	621	6	)	)	PUNCT
admet-276	621	7	215	215	NUM
admet-276	621	8	-	-	SYM
admet-276	621	9	230	230	NUM
admet-276	621	10	.	.	PUNCT
admet-276	622	1	[	[	X
admet-276	622	2	100	100	NUM
admet-276	622	3	]	]	X
admet-276	622	4	o.l	o.l	PROPN
admet-276	622	5	.	.	PROPN
admet-276	622	6	blanchard	blanchard	PROPN
admet-276	622	7	,	,	PUNCT
admet-276	622	8	j.m	j.m	PROPN
admet-276	622	9	.	.	PROPN
admet-276	622	10	smoliga	smoliga	PROPN
admet-276	622	11	.	.	PUNCT
admet-276	623	1	faseb	faseb	PROPN
admet-276	623	2	j.	j.	PROPN
admet-276	623	3	29	29	NUM
admet-276	623	4	(	(	PUNCT
admet-276	623	5	2015	2015	NUM
admet-276	623	6	)	)	PUNCT
admet-276	623	7	1629	1629	NUM
admet-276	623	8	-	-	SYM
admet-276	623	9	1634	1634	NUM
admet-276	623	10	.	.	PUNCT
admet-276	624	1	[	[	X
admet-276	624	2	101	101	NUM
admet-276	624	3	]	]	PUNCT
admet-276	624	4	l.	l.	PROPN
admet-276	624	5	diao	diao	PROPN
admet-276	624	6	,	,	PUNCT
admet-276	624	7	b.	b.	PROPN
admet-276	624	8	meibohm	meibohm	PROPN
admet-276	624	9	.	.	PUNCT
admet-276	625	1	expert	expert	NOUN
admet-276	625	2	opin	opin	NOUN
admet-276	625	3	.	.	PUNCT
admet-276	626	1	drug	drug	NOUN
admet-276	626	2	metab	metab	NOUN
admet-276	626	3	.	.	PUNCT
admet-276	627	1	toxicol	toxicol	PROPN
admet-276	627	2	.	.	PUNCT
admet-276	628	1	11	11	NUM
admet-276	628	2	(	(	PUNCT
admet-276	628	3	2015	2015	NUM
admet-276	628	4	)	)	PUNCT
admet-276	628	5	1115	1115	NUM
admet-276	628	6	-	-	SYM
admet-276	628	7	1125	1125	NUM
admet-276	628	8	.	.	PUNCT
admet-276	629	1	[	[	X
admet-276	629	2	102	102	NUM
admet-276	629	3	]	]	X
admet-276	629	4	h.m	h.m	PROPN
admet-276	629	5	.	.	PROPN
admet-276	629	6	jones	jones	PROPN
admet-276	629	7	,	,	PUNCT
admet-276	629	8	y.	y.	PROPN
admet-276	629	9	chen	chen	PROPN
admet-276	629	10	,	,	PUNCT
admet-276	629	11	c.	c.	PROPN
admet-276	629	12	gibson	gibson	PROPN
admet-276	629	13	,	,	PUNCT
admet-276	629	14	t.	t.	PROPN
admet-276	629	15	heimbach	heimbach	NOUN
admet-276	629	16	,	,	PUNCT
admet-276	629	17	n.	n.	PROPN
admet-276	629	18	parrott	parrott	PROPN
admet-276	629	19	,	,	PUNCT
admet-276	629	20	s.a	s.a	PROPN
admet-276	629	21	.	.	PROPN
admet-276	629	22	peters	peters	PROPN
admet-276	629	23	,	,	PUNCT
admet-276	629	24	j.	j.	PROPN
admet-276	629	25	snoeys	snoeys	PROPN
admet-276	629	26	,	,	PUNCT
admet-276	629	27	v.v	v.v	PROPN
admet-276	629	28	.	.	PROPN
admet-276	629	29	upreti	upreti	PROPN
admet-276	629	30	,	,	PUNCT
admet-276	629	31	m.	m.	NOUN
admet-276	629	32	zheng	zheng	PROPN
admet-276	629	33	s.d	s.d	PROPN
admet-276	629	34	.	.	PROPN
admet-276	629	35	hall	hall	PROPN
admet-276	629	36	.	.	PUNCT
admet-276	630	1	clin	clin	PROPN
admet-276	630	2	.	.	PUNCT
admet-276	631	1	pharmacol	pharmacol	PROPN
admet-276	631	2	.	.	PUNCT
admet-276	632	1	ther	ther	PROPN
admet-276	632	2	.	.	PUNCT
admet-276	633	1	97	97	NUM
admet-276	633	2	(	(	PUNCT
admet-276	633	3	2015	2015	NUM
admet-276	633	4	)	)	PUNCT
admet-276	633	5	247	247	NUM
admet-276	633	6	-	-	SYM
admet-276	633	7	262	262	NUM
admet-276	633	8	.	.	PUNCT
admet-276	634	1	[	[	X
admet-276	634	2	103	103	NUM
admet-276	634	3	]	]	X
admet-276	634	4	y.	y.	PROPN
admet-276	634	5	cao	cao	PROPN
admet-276	634	6	,	,	PUNCT
admet-276	634	7	w.j	w.j	PROPN
admet-276	634	8	.	.	PROPN
admet-276	634	9	jusko	jusko	PROPN
admet-276	634	10	.	.	PUNCT
admet-276	635	1	j.	j.	PROPN
admet-276	635	2	pharmacokinet	pharmacokinet	PROPN
admet-276	635	3	.	.	PUNCT
admet-276	636	1	pharmacodyn	pharmacodyn	ADV
admet-276	636	2	.	.	PUNCT
admet-276	637	1	41	41	NUM
admet-276	637	2	(	(	PUNCT
admet-276	637	3	2014	2014	NUM
admet-276	637	4	)	)	PUNCT
admet-276	637	5	571	571	NUM
admet-276	637	6	-	-	SYM
admet-276	637	7	580	580	NUM
admet-276	637	8	.	.	PUNCT
admet-276	638	1	[	[	X
admet-276	638	2	104	104	X
admet-276	638	3	]	]	PUNCT
admet-276	638	4	j.	j.	PROPN
admet-276	638	5	wang	wang	PROPN
admet-276	638	6	,	,	PUNCT
admet-276	638	7	s.	s.	PROPN
admet-276	638	8	iyer	iyer	PROPN
admet-276	638	9	,	,	PUNCT
admet-276	638	10	p.j	p.j	PROPN
admet-276	638	11	.	.	PROPN
admet-276	638	12	fielder	fielder	NOUN
admet-276	638	13	,	,	PUNCT
admet-276	638	14	j.d	j.d	PROPN
admet-276	638	15	.	.	PROPN
admet-276	638	16	davis	davis	PROPN
admet-276	638	17	,	,	PUNCT
admet-276	638	18	r.	r.	PROPN
admet-276	638	19	deng	deng	PROPN
admet-276	638	20	.	.	PUNCT
admet-276	639	1	biopharm	biopharm	PROPN
admet-276	639	2	.	.	PUNCT
admet-276	640	1	drug	drug	NOUN
admet-276	640	2	dispos	dispos	PROPN
admet-276	640	3	.	.	PUNCT
admet-276	641	1	2015	2015	NUM
admet-276	641	2	.	.	PUNCT
admet-276	642	1	[	[	X
admet-276	642	2	105	105	NUM
admet-276	642	3	]	]	X
admet-276	642	4	l.	l.	PROPN
admet-276	642	5	gibiansky	gibiansky	PROPN
admet-276	642	6	,	,	PUNCT
admet-276	642	7	e.	e.	PROPN
admet-276	642	8	gibiansky	gibiansky	PROPN
admet-276	642	9	.	.	PUNCT
admet-276	643	1	j.	j.	PROPN
admet-276	643	2	pharmacokinet	pharmacokinet	PROPN
admet-276	643	3	.	.	PUNCT
admet-276	644	1	pharmacodyn	pharmacodyn	ADV
admet-276	644	2	.	.	PUNCT
admet-276	645	1	41	41	NUM
admet-276	645	2	(	(	PUNCT
admet-276	645	3	2014	2014	NUM
admet-276	645	4	)	)	PUNCT
admet-276	645	5	35	35	NUM
admet-276	645	6	-	-	SYM
admet-276	645	7	47	47	NUM
admet-276	645	8	.	.	PUNCT
admet-276	646	1	[	[	X
admet-276	646	2	106	106	X
admet-276	646	3	]	]	X
admet-276	646	4	y.	y.	PROPN
admet-276	646	5	chen	chen	PROPN
admet-276	646	6	,	,	PUNCT
admet-276	646	7	d.	d.	PROPN
admet-276	646	8	samineni	samineni	PROPN
admet-276	646	9	,	,	PUNCT
admet-276	646	10	s.	s.	PROPN
admet-276	646	11	mukadam	mukadam	PROPN
admet-276	646	12	,	,	PUNCT
admet-276	646	13	h.	h.	PROPN
admet-276	646	14	wong	wong	PROPN
admet-276	646	15	,	,	PUNCT
admet-276	646	16	b.q	b.q	PROPN
admet-276	646	17	.	.	PROPN
admet-276	646	18	shen	shen	PROPN
admet-276	646	19	,	,	PUNCT
admet-276	646	20	d.	d.	PROPN
admet-276	646	21	lu	lu	PROPN
admet-276	646	22	,	,	PUNCT
admet-276	646	23	s.	s.	PROPN
admet-276	646	24	girish	girish	PROPN
admet-276	646	25	,	,	PUNCT
admet-276	646	26	c.	c.	PROPN
admet-276	646	27	hop	hop	PROPN
admet-276	646	28	,	,	PUNCT
admet-276	646	29	j.y	j.y	PROPN
admet-276	646	30	.	.	PROPN
admet-276	646	31	jin	jin	PROPN
admet-276	646	32	,	,	PUNCT
admet-276	646	33	c.	c.	PROPN
admet-276	646	34	li	li	PROPN
admet-276	646	35	.	.	PROPN
admet-276	646	36	clin	clin	PROPN
admet-276	646	37	.	.	PUNCT
admet-276	647	1	pharmacokinet	pharmacokinet	PROPN
admet-276	647	2	.	.	PUNCT
admet-276	648	1	54	54	NUM
admet-276	648	2	(	(	PUNCT
admet-276	648	3	2015	2015	NUM
admet-276	648	4	)	)	PUNCT
admet-276	648	5	81	81	NUM
admet-276	648	6	-	-	SYM
admet-276	648	7	93	93	NUM
admet-276	648	8	.	.	PUNCT
admet-276	649	1	[	[	X
admet-276	649	2	107	107	NUM
admet-276	649	3	]	]	PUNCT
admet-276	649	4	adcetris	adcetris	NOUN
admet-276	649	5	,	,	PUNCT
admet-276	649	6	fda	fda	PROPN
admet-276	649	7	cder	cder	NOUN
admet-276	649	8	(	(	PUNCT
admet-276	649	9	center	center	NOUN
admet-276	649	10	for	for	ADP
admet-276	649	11	drug	drug	NOUN
admet-276	649	12	evaluation	evaluation	NOUN
admet-276	649	13	and	and	CCONJ
admet-276	649	14	research	research	NOUN
admet-276	649	15	)	)	PUNCT
admet-276	649	16	,	,	PUNCT
admet-276	649	17	pharmacology	pharmacology	NOUN
admet-276	649	18	review	review	NOUN
admet-276	649	19	,	,	PUNCT
admet-276	649	20	application	application	NOUN
admet-276	649	21	number	number	NOUN
admet-276	649	22	125399orig1s000	125399orig1s000	NUM
admet-276	649	23	,	,	PUNCT
admet-276	649	24	2011	2011	NUM
admet-276	649	25	.	.	PUNCT
admet-276	650	1	available	available	ADJ
admet-276	650	2	from	from	ADP
admet-276	650	3	:	:	PUNCT
admet-276	650	4	http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125388s000,125399s000lbl.pdf	http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125388s000,125399s000lbl.pdf	NOUN
admet-276	650	5	.	.	PUNCT
admet-276	651	1	[	[	X
admet-276	651	2	108	108	NUM
admet-276	651	3	]	]	PUNCT
admet-276	651	4	adcetris	adcetris	NOUN
admet-276	651	5	,	,	PUNCT
admet-276	651	6	fda	fda	PROPN
admet-276	651	7	cder	cder	NOUN
admet-276	651	8	(	(	PUNCT
admet-276	651	9	center	center	NOUN
admet-276	651	10	for	for	ADP
admet-276	651	11	drug	drug	NOUN
admet-276	651	12	evaluation	evaluation	NOUN
admet-276	651	13	and	and	CCONJ
admet-276	651	14	research	research	NOUN
admet-276	651	15	)	)	PUNCT
admet-276	651	16	,	,	PUNCT
admet-276	651	17	clinical	clinical	ADJ
admet-276	651	18	pharmacology	pharmacology	NOUN
admet-276	651	19	and	and	CCONJ
admet-276	651	20	biopharmaceutics	biopharmaceutics	NOUN
admet-276	651	21	review	review	NOUN
admet-276	651	22	,	,	PUNCT
admet-276	651	23	application	application	NOUN
admet-276	651	24	number	number	NOUN
admet-276	651	25	125399orig1s000	125399orig1s000	NUM
admet-276	651	26	,	,	PUNCT
admet-276	651	27	2011	2011	NUM
admet-276	651	28	.	.	PUNCT
admet-276	652	1	available	available	ADJ
admet-276	652	2	from	from	ADP
admet-276	652	3	:	:	PUNCT
admet-276	652	4	http://www.accessdata.fda.gov	http://www.accessdata.fda.gov	NOUN
admet-276	652	5	/	/	SYM
admet-276	652	6	drugsatfda_docs	drugsatfda_doc	NOUN
admet-276	652	7	/	/	SYM
admet-276	652	8	label/2011/125388s000,125399s000lbl.pdf	label/2011/125388s000,125399s000lbl.pdf	PROPN
admet-276	652	9	.	.	PUNCT
admet-276	653	1	(	(	PUNCT
admet-276	653	2	accessed	access	VERB
admet-276	653	3	on	on	ADP
admet-276	653	4	march	march	PROPN
admet-276	653	5	23	23	NUM
admet-276	653	6	,	,	PUNCT
admet-276	653	7	2016	2016	NUM
admet-276	653	8	)	)	PUNCT
admet-276	653	9	.	.	PUNCT
admet-276	654	1	[	[	X
admet-276	654	2	109	109	NUM
admet-276	654	3	]	]	PUNCT
admet-276	654	4	kacyla	kacyla	NOUN
admet-276	654	5	ema	ema	PROPN
admet-276	654	6	-	-	PUNCT
admet-276	654	7	assessment	assessment	NOUN
admet-276	654	8	report	report	NOUN
admet-276	654	9	on	on	ADP
admet-276	654	10	kadcyla	kadcyla	ADV
admet-276	654	11	-	-	PUNCT
admet-276	654	12	ema749228	ema749228	PROPN
admet-276	654	13	-	-	PROPN
admet-276	654	14	2013	2013	NUM
admet-276	654	15	.	.	PUNCT
admet-276	655	1	available	available	ADJ
admet-276	655	2	from	from	ADP
admet-276	655	3	:	:	PUNCT
admet-276	655	4	http://www.ema.europa.eu/docs/en_gb/document_library/epar__public_assessment_report/human/002389/wc500158595.pdf	http://www.ema.europa.eu/docs/en_gb/document_library/epar__public_assessment_report/human/002389/wc500158595.pdf	NOUN
admet-276	655	5	.	.	PUNCT
admet-276	656	1	(	(	PUNCT
admet-276	656	2	accessed	access	VERB
admet-276	656	3	on	on	ADP
admet-276	656	4	march	march	PROPN
admet-276	656	5	23	23	NUM
admet-276	656	6	,	,	PUNCT
admet-276	656	7	2016	2016	NUM
admet-276	656	8	)	)	PUNCT
admet-276	656	9	.	.	PUNCT
admet-276	657	1	[	[	X
admet-276	657	2	110	110	NUM
admet-276	657	3	]	]	X
admet-276	657	4	kadcyla	kadcyla	NOUN
admet-276	657	5	,	,	PUNCT
admet-276	657	6	fda	fda	PROPN
admet-276	657	7	cder	cder	NOUN
admet-276	657	8	(	(	PUNCT
admet-276	657	9	center	center	NOUN
admet-276	657	10	for	for	ADP
admet-276	657	11	drug	drug	NOUN
admet-276	657	12	evaluation	evaluation	NOUN
admet-276	657	13	and	and	CCONJ
admet-276	657	14	research	research	NOUN
admet-276	657	15	)	)	PUNCT
admet-276	657	16	,	,	PUNCT
admet-276	657	17	pharmacology	pharmacology	NOUN
admet-276	657	18	review	review	NOUN
admet-276	657	19	,	,	PUNCT
admet-276	657	20	application	application	NOUN
admet-276	657	21	number	number	NOUN
admet-276	657	22	125427orig1s000	125427orig1s000	NUM
admet-276	657	23	,	,	PUNCT
admet-276	657	24	2013	2013	NUM
admet-276	657	25	.	.	PUNCT
admet-276	658	1	available	available	ADJ
admet-276	658	2	from	from	ADP
admet-276	658	3	:	:	PUNCT
admet-276	658	4	http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125427lbl.pdf	http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125427lbl.pdf	PROPN
admet-276	658	5	.	.	PUNCT
admet-276	659	1	(	(	PUNCT
admet-276	659	2	accessed	access	VERB
admet-276	659	3	on	on	ADP
admet-276	659	4	march	march	PROPN
admet-276	659	5	23	23	NUM
admet-276	659	6	,	,	PUNCT
admet-276	659	7	2016	2016	NUM
admet-276	659	8	)	)	PUNCT
admet-276	659	9	.	.	PUNCT
admet-276	660	1	[	[	X
admet-276	660	2	111	111	NUM
admet-276	660	3	]	]	X
admet-276	660	4	a.p	a.p	PROPN
admet-276	660	5	.	.	PROPN
admet-276	660	6	singh	singh	PROPN
admet-276	660	7	,	,	PUNCT
admet-276	660	8	y.g	y.g	PROPN
admet-276	660	9	.	.	PROPN
admet-276	660	10	shin	shin	PROPN
admet-276	660	11	,	,	PUNCT
admet-276	660	12	d.k	d.k	PROPN
admet-276	660	13	.	.	PROPN
admet-276	660	14	shah	shah	PROPN
admet-276	660	15	.	.	PUNCT
admet-276	661	1	pharm	pharm	PROPN
admet-276	661	2	.	.	PUNCT
admet-276	662	1	res	re	NOUN
admet-276	662	2	.	.	PUNCT
admet-276	663	1	32	32	NUM
admet-276	663	2	(	(	PUNCT
admet-276	663	3	2015	2015	NUM
admet-276	663	4	)	)	PUNCT
admet-276	663	5	3508	3508	NUM
admet-276	663	6	-	-	SYM
admet-276	663	7	3525	3525	NUM
admet-276	663	8	.	.	PUNCT
admet-276	664	1	[	[	X
admet-276	664	2	112	112	NUM
admet-276	664	3	]	]	PUNCT
admet-276	664	4	p.	p.	PROPN
admet-276	664	5	sapra	sapra	PROPN
admet-276	664	6	,	,	PUNCT
admet-276	664	7	a.	a.	PROPN
admet-276	664	8	betts	betts	PROPN
admet-276	664	9	,	,	PUNCT
admet-276	664	10	j.	j.	PROPN
admet-276	664	11	boni	boni	PROPN
admet-276	664	12	.	.	PUNCT
admet-276	665	1	expert	expert	PROPN
admet-276	665	2	rev	rev	VERB
admet-276	665	3	.	.	PROPN
admet-276	666	1	clin	clin	PROPN
admet-276	666	2	.	.	PUNCT
admet-276	667	1	pharmacol	pharmacol	PROPN
admet-276	667	2	.	.	PROPN
admet-276	668	1	6	6	NUM
admet-276	668	2	(	(	PUNCT
admet-276	668	3	2013	2013	NUM
admet-276	668	4	)	)	PUNCT
admet-276	668	5	541	541	NUM
admet-276	668	6	-	-	SYM
admet-276	668	7	555	555	NUM
admet-276	668	8	.	.	PUNCT
admet-276	669	1	[	[	X
admet-276	669	2	113	113	NUM
admet-276	669	3	]	]	X
admet-276	669	4	d.k	d.k	PROPN
admet-276	669	5	.	.	PROPN
admet-276	669	6	shah	shah	PROPN
admet-276	669	7	,	,	PUNCT
admet-276	669	8	n.	n.	PROPN
admet-276	669	9	haddish	haddish	PROPN
admet-276	669	10	-	-	PUNCT
admet-276	669	11	berhane	berhane	NOUN
admet-276	669	12	,	,	PUNCT
admet-276	669	13	a.	a.	PROPN
admet-276	669	14	betts	betts	PROPN
admet-276	669	15	.	.	PUNCT
admet-276	670	1	j.	j.	PROPN
admet-276	670	2	pharmacokinet	pharmacokinet	PROPN
admet-276	670	3	.	.	PUNCT
admet-276	671	1	pharmacodyn	pharmacodyn	ADV
admet-276	671	2	.	.	PUNCT
admet-276	672	1	39	39	NUM
admet-276	672	2	(	(	PUNCT
admet-276	672	3	2012	2012	NUM
admet-276	672	4	)	)	PUNCT
admet-276	672	5	643	643	NUM
admet-276	672	6	-	-	SYM
admet-276	672	7	659	659	NUM
admet-276	672	8	.	.	PUNCT
admet-276	673	1	[	[	X
admet-276	673	2	114	114	NUM
admet-276	673	3	]	]	PUNCT
admet-276	673	4	a.	a.	NOUN
admet-276	673	5	khot	khot	PROPN
admet-276	673	6	,	,	PUNCT
admet-276	673	7	s.	s.	PROPN
admet-276	673	8	sharma	sharma	PROPN
admet-276	673	9	,	,	PUNCT
admet-276	673	10	d.k	d.k	PROPN
admet-276	673	11	.	.	PROPN
admet-276	673	12	shah	shah	PROPN
admet-276	673	13	.	.	PUNCT
admet-276	674	1	bioanalysis	bioanalysis	NOUN
admet-276	674	2	7	7	NUM
admet-276	674	3	(	(	PUNCT
admet-276	674	4	2015	2015	NUM
admet-276	674	5	)	)	PUNCT
admet-276	674	6	1633	1633	NUM
admet-276	674	7	-	-	SYM
admet-276	674	8	1648	1648	NUM
admet-276	674	9	.	.	PUNCT
admet-276	675	1	[	[	X
admet-276	675	2	115	115	NUM
admet-276	675	3	]	]	X
admet-276	675	4	h.	h.	PROPN
admet-276	675	5	saber	saber	PROPN
admet-276	675	6	,	,	PUNCT
admet-276	675	7	j.k	j.k	PROPN
admet-276	675	8	.	.	PROPN
admet-276	675	9	leighton	leighton	PROPN
admet-276	675	10	.	.	PUNCT
admet-276	676	1	regul	regul	NOUN
admet-276	676	2	.	.	PUNCT
admet-276	677	1	toxicol	toxicol	PROPN
admet-276	677	2	.	.	PUNCT
admet-276	678	1	pharmacol	pharmacol	PROPN
admet-276	678	2	.	.	PUNCT
admet-276	679	1	71	71	NUM
admet-276	679	2	(	(	PUNCT
admet-276	679	3	2015	2015	NUM
admet-276	679	4	)	)	PUNCT
admet-276	679	5	444	444	NUM
admet-276	679	6	-	-	SYM
admet-276	679	7	452	452	NUM
admet-276	679	8	.	.	PUNCT
admet-276	680	1	hong	hong	PROPN
admet-276	680	2	wan	wan	PROPN
admet-276	680	3	admet	admet	PROPN
admet-276	680	4	&	&	CCONJ
admet-276	680	5	dmpk	dmpk	PROPN
admet-276	680	6	4(1	4(1	NOUN
admet-276	680	7	)	)	PUNCT
admet-276	680	8	(	(	PUNCT
admet-276	680	9	2016	2016	NUM
admet-276	680	10	)	)	PUNCT
admet-276	680	11	1	1	NUM
admet-276	680	12	-	-	SYM
admet-276	680	13	22	22	NUM
admet-276	680	14	22	22	NUM
admet-276	680	15	abbreviations	abbreviation	NOUN
admet-276	680	16	:	:	PUNCT
admet-276	680	17	aaps	aaps	PROPN
admet-276	680	18	american	american	PROPN
admet-276	680	19	association	association	PROPN
admet-276	680	20	of	of	ADP
admet-276	680	21	pharmaceutical	pharmaceutical	PROPN
admet-276	680	22	scientists	scientist	NOUN
admet-276	680	23	ada	ada	PROPN
admet-276	680	24	anti	anti	ADJ
admet-276	680	25	-	-	ADJ
admet-276	680	26	drug	drug	ADJ
admet-276	680	27	antibody	antibody	NOUN
admet-276	680	28	adc	adc	NOUN
admet-276	680	29	antibody	antibody	NOUN
admet-276	680	30	-	-	PUNCT
admet-276	680	31	drug	drug	NOUN
admet-276	680	32	conjugates	conjugate	NOUN
admet-276	680	33	adme	adme	VERB
admet-276	680	34	absorption	absorption	NOUN
admet-276	680	35	,	,	PUNCT
admet-276	680	36	distribution	distribution	NOUN
admet-276	680	37	,	,	PUNCT
admet-276	680	38	metabolism	metabolism	NOUN
admet-276	680	39	and	and	CCONJ
admet-276	680	40	elimination	elimination	NOUN
admet-276	680	41	api	api	NOUN
admet-276	680	42	active	active	ADJ
admet-276	680	43	pharmaceutical	pharmaceutical	ADJ
admet-276	680	44	ingredient	ingredient	NOUN
admet-276	680	45	ata	ata	VERB
admet-276	680	46	anti	anti	ADJ
admet-276	680	47	-	-	ADJ
admet-276	680	48	therapeutic	therapeutic	ADJ
admet-276	680	49	antibodies	antibody	NOUN
admet-276	680	50	auc	auc	NOUN
admet-276	680	51	area	area	NOUN
admet-276	680	52	under	under	ADP
admet-276	680	53	the	the	DET
admet-276	680	54	curve	curve	NOUN
admet-276	680	55	bsa	bsa	PROPN
admet-276	680	56	body	body	PROPN
admet-276	680	57	surface	surface	PROPN
admet-276	680	58	area	area	PROPN
admet-276	680	59	cder	cder	PROPN
admet-276	680	60	center	center	PROPN
admet-276	680	61	for	for	ADP
admet-276	680	62	drug	drug	NOUN
admet-276	680	63	evaluation	evaluation	NOUN
admet-276	680	64	and	and	CCONJ
admet-276	680	65	research	research	NOUN
admet-276	680	66	cyp	cyp	ADJ
admet-276	680	67	cytochrome	cytochrome	NOUN
admet-276	680	68	p450	p450	PROPN
admet-276	680	69	dar	dar	NOUN
admet-276	680	70	drug	drug	NOUN
admet-276	680	71	-	-	PUNCT
admet-276	680	72	antibody	antibody	NOUN
admet-276	680	73	ratio	ratio	NOUN
admet-276	680	74	,	,	PUNCT
admet-276	680	75	payload	payload	NOUN
admet-276	680	76	ddi	ddi	ADJ
admet-276	680	77	drug	drug	NOUN
admet-276	680	78	-	-	PUNCT
admet-276	680	79	drug	drug	NOUN
admet-276	680	80	interaction	interaction	NOUN
admet-276	680	81	etapc	etapc	NOUN
admet-276	680	82	the	the	DET
admet-276	680	83	emergent	emergent	ADJ
admet-276	680	84	technologies	technology	NOUN
admet-276	680	85	action	action	NOUN
admet-276	680	86	program	program	NOUN
admet-276	680	87	committee	committee	NOUN
admet-276	680	88	elisa	elisa	NOUN
admet-276	680	89	enzyme	enzyme	NOUN
admet-276	680	90	-	-	PUNCT
admet-276	680	91	linked	link	VERB
admet-276	680	92	immunesorbent	immunesorbent	NOUN
admet-276	680	93	assay	assay	PROPN
admet-276	680	94	fih	fih	NOUN
admet-276	680	95	first	first	ADJ
admet-276	680	96	-	-	PUNCT
admet-276	680	97	in	in	ADP
admet-276	680	98	-	-	PUNCT
admet-276	680	99	human	human	ADJ
admet-276	680	100	herg	herg	PROPN
admet-276	680	101	human	human	ADJ
admet-276	680	102	ether	ether	NOUN
admet-276	680	103	-	-	PUNCT
admet-276	680	104	a	a	DET
admet-276	680	105	-	-	PUNCT
admet-276	680	106	go	go	NOUN
admet-276	680	107	-	-	PUNCT
admet-276	680	108	go	go	NOUN
admet-276	680	109	related	relate	VERB
admet-276	680	110	gene	gene	NOUN
admet-276	680	111	hic	hic	ADJ
admet-276	680	112	hydrophobic	hydrophobic	NOUN
admet-276	680	113	interaction	interaction	NOUN
admet-276	680	114	chromatography	chromatography	NOUN
admet-276	680	115	hnstd	hnstd	PROPN
admet-276	680	116	highest	high	ADJ
admet-276	680	117	non	non	ADJ
admet-276	680	118	-	-	ADJ
admet-276	680	119	severely	severely	ADV
admet-276	680	120	toxic	toxic	ADJ
admet-276	680	121	dose	dose	NOUN
admet-276	680	122	lba	lba	NOUN
admet-276	680	123	ligand	ligand	VERB
admet-276	680	124	binding	bind	VERB
admet-276	680	125	assay	assay	PROPN
admet-276	680	126	igg	igg	PROPN
admet-276	680	127	immunoglobulin	immunoglobulin	PROPN
admet-276	680	128	g	g	PROPN
admet-276	681	1	i	i	PRON
admet-276	681	2	m	m	VERB
admet-276	681	3	intramuscular	intramuscular	ADJ
admet-276	681	4	ind	ind	ADJ
admet-276	681	5	investigational	investigational	ADJ
admet-276	681	6	new	new	ADJ
admet-276	681	7	drug	drug	NOUN
admet-276	681	8	is	be	AUX
admet-276	681	9	internal	internal	ADJ
admet-276	681	10	standard	standard	ADJ
admet-276	681	11	iv	iv	NUM
admet-276	681	12	intravenous	intravenous	ADJ
admet-276	681	13	lc	lc	PROPN
admet-276	681	14	-	-	PUNCT
admet-276	681	15	ms	ms	NOUN
admet-276	681	16	liquid	liquid	ADJ
admet-276	681	17	chromatography	chromatography	NOUN
admet-276	681	18	-	-	PUNCT
admet-276	681	19	mass	mass	NOUN
admet-276	681	20	spectrometry	spectrometry	NOUN
admet-276	681	21	lc	lc	PROPN
admet-276	681	22	-	-	PUNCT
admet-276	681	23	ms	ms	PROPN
admet-276	681	24	/	/	SYM
admet-276	681	25	ms	ms	NOUN
admet-276	681	26	liquid	liquid	ADJ
admet-276	681	27	chromatography	chromatography	NOUN
admet-276	681	28	with	with	ADP
admet-276	681	29	tandem	tandem	PROPN
admet-276	681	30	mass	mass	PROPN
admet-276	681	31	spectrometry	spectrometry	NOUN
admet-276	681	32	lms	lm	NOUN
admet-276	681	33	large	large	ADJ
admet-276	681	34	molecules	molecule	NOUN
admet-276	681	35	mab	mab	NOUN
admet-276	681	36	monoclonal	monoclonal	NOUN
admet-276	681	37	antibody	antibody	NOUN
admet-276	681	38	mmae	mmae	NOUN
admet-276	681	39	monomethyl	monomethyl	PROPN
admet-276	681	40	auristatin	auristatin	PROPN
admet-276	682	1	e	e	ADP
admet-276	682	2	m&s	m&s	PROPN
admet-276	682	3	modeling	modeling	NOUN
admet-276	682	4	and	and	CCONJ
admet-276	682	5	simulation	simulation	NOUN
admet-276	682	6	mtd	mtd	PROPN
admet-276	682	7	maximum	maximum	PROPN
admet-276	682	8	tolerated	tolerate	VERB
admet-276	682	9	dose	dose	NOUN
admet-276	682	10	mw	mw	X
admet-276	682	11	molecular	molecular	ADJ
admet-276	682	12	weight	weight	NOUN
admet-276	682	13	pbpk	pbpk	NOUN
admet-276	682	14	physiologically	physiologically	ADV
admet-276	682	15	-	-	PUNCT
admet-276	682	16	based	base	VERB
admet-276	682	17	pharmacokinetics	pharmacokinetic	NOUN
admet-276	682	18	pcc	pcc	NOUN
admet-276	682	19	preclinical	preclinical	ADJ
admet-276	682	20	candidate	candidate	NOUN
admet-276	682	21	pd	pd	PROPN
admet-276	682	22	pharmacodynamics	pharmacodynamic	NOUN
admet-276	682	23	pk	pk	NOUN
admet-276	682	24	pharmacokinetics	pharmacokinetic	NOUN
admet-276	682	25	pk	pk	NOUN
admet-276	682	26	/	/	SYM
admet-276	682	27	pd	pd	NOUN
admet-276	682	28	pharmacokinetics	pharmacokinetic	NOUN
admet-276	682	29	-	-	PUNCT
admet-276	682	30	pharmacodynamics	pharmacodynamic	NOUN
admet-276	682	31	pk	pk	NOUN
admet-276	682	32	/	/	SYM
admet-276	682	33	tk	tk	NOUN
admet-276	682	34	pharmacokinetics	pharmacokinetic	NOUN
admet-276	682	35	-	-	PUNCT
admet-276	682	36	toxicokinetics	toxicokinetic	NOUN
admet-276	682	37	ptm	ptm	NOUN
admet-276	682	38	post	post	ADJ
admet-276	682	39	-	-	ADJ
admet-276	682	40	translational	translational	ADJ
admet-276	682	41	modifications	modification	NOUN
admet-276	682	42	sc	sc	PROPN
admet-276	682	43	subcutaneous	subcutaneous	ADJ
admet-276	682	44	sms	sms	PROPN
admet-276	682	45	small	small	ADJ
admet-276	682	46	molecules	molecule	NOUN
admet-276	682	47	tdc	tdc	PROPN
admet-276	682	48	thiomab	thiomab	NOUN
admet-276	682	49	-	-	PUNCT
admet-276	682	50	drug	drug	NOUN
admet-276	682	51	conjugates	conjugate	NOUN
admet-276	682	52	t	t	PROPN
admet-276	682	53	-	-	PUNCT
admet-276	682	54	dm1	dm1	NOUN
admet-276	682	55	trastuzumab	trastuzumab	NOUN
admet-276	682	56	-	-	PUNCT
admet-276	682	57	emtansine	emtansine	NOUN
admet-276	682	58	tmb	tmb	NOUN
admet-276	682	59	3	3	NUM
admet-276	682	60	,	,	PUNCT
admet-276	682	61	3	3	NUM
admet-276	682	62	'	'	NUM
admet-276	682	63	,	,	PUNCT
admet-276	682	64	5	5	NUM
admet-276	682	65	,	,	PUNCT
admet-276	682	66	5	5	NUM
admet-276	682	67	'	'	PART
admet-276	682	68	tetramethylbenzidine	tetramethylbenzidine	NOUN
admet-276	682	69	tmdd	tmdd	PROPN
admet-276	682	70	target	target	NOUN
admet-276	682	71	-	-	PUNCT
admet-276	682	72	mediated	mediate	VERB
admet-276	682	73	drug	drug	NOUN
admet-276	682	74	disposition	disposition	NOUN
admet-276	682	75	vd	vd	NOUN
admet-276	682	76	volume	volume	NOUN
admet-276	682	77	of	of	ADP
admet-276	682	78	distribution	distribution	NOUN
admet-276	682	79	©	©	PROPN
admet-276	682	80	2016	2016	NUM
admet-276	682	81	by	by	ADP
admet-276	682	82	the	the	DET
admet-276	682	83	authors	author	NOUN
admet-276	682	84	;	;	PUNCT
admet-276	682	85	licensee	licensee	PROPN
admet-276	682	86	iapc	iapc	PROPN
admet-276	682	87	,	,	PUNCT
admet-276	682	88	zagreb	zagreb	PROPN
admet-276	682	89	,	,	PUNCT
admet-276	682	90	croatia	croatia	PROPN
admet-276	682	91	.	.	PUNCT
admet-276	683	1	this	this	DET
admet-276	683	2	article	article	NOUN
admet-276	683	3	is	be	AUX
admet-276	683	4	an	an	DET
admet-276	683	5	open	open	ADJ
admet-276	683	6	-	-	PUNCT
admet-276	683	7	access	access	NOUN
admet-276	683	8	article	article	NOUN
admet-276	683	9	distributed	distribute	VERB
admet-276	683	10	under	under	ADP
admet-276	683	11	the	the	DET
admet-276	683	12	terms	term	NOUN
admet-276	683	13	and	and	CCONJ
admet-276	683	14	conditions	condition	NOUN
admet-276	683	15	of	of	ADP
admet-276	683	16	the	the	DET
admet-276	683	17	creative	creative	ADJ
admet-276	683	18	commons	common	NOUN
admet-276	683	19	attribution	attribution	NOUN
admet-276	683	20	license	license	NOUN
admet-276	683	21	(	(	PUNCT
admet-276	683	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-276	683	23	)	)	PUNCT
admet-276	683	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN