id	sid	tid	token	lemma	pos
admet-277	1	1	manuscript	manuscript	PROPN
admet-277	1	2	doi	doi	PROPN
admet-277	1	3	:	:	PUNCT
admet-277	1	4	10.5599	10.5599	NUM
admet-277	1	5	/	/	SYM
admet-277	1	6	admet.4.1.277	admet.4.1.277	PROPN
admet-277	1	7	54	54	NUM
admet-277	1	8	admet	admet	X
admet-277	1	9	&	&	CCONJ
admet-277	1	10	dmpk	dmpk	PROPN
admet-277	1	11	4(1	4(1	NOUN
admet-277	1	12	)	)	PUNCT
admet-277	1	13	(	(	PUNCT
admet-277	1	14	2016	2016	NUM
admet-277	1	15	)	)	PUNCT
admet-277	1	16	54	54	NUM
admet-277	1	17	-	-	SYM
admet-277	1	18	59	59	NUM
admet-277	1	19	;	;	PUNCT
admet-277	1	20	doi	doi	NOUN
admet-277	1	21	:	:	PUNCT
admet-277	1	22	10.5599	10.5599	NUM
admet-277	1	23	/	/	SYM
admet-277	1	24	admet.4.1.277	admet.4.1.277	PROPN
admet-277	1	25	open	open	ADJ
admet-277	1	26	access	access	NOUN
admet-277	1	27	:	:	PUNCT
admet-277	1	28	issn	issn	PROPN
admet-277	1	29	:	:	PUNCT
admet-277	1	30	1848	1848	NUM
admet-277	1	31	-	-	SYM
admet-277	1	32	7718	7718	NUM
admet-277	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-277	1	34	original	original	ADJ
admet-277	1	35	scientific	scientific	ADJ
admet-277	1	36	paper	paper	NOUN
admet-277	1	37	reversed	reverse	VERB
admet-277	1	38	phase	phase	NOUN
admet-277	1	39	parallel	parallel	ADJ
admet-277	1	40	artificial	artificial	ADJ
admet-277	1	41	membrane	membrane	NOUN
admet-277	1	42	permeation	permeation	NOUN
admet-277	1	43	assay	assay	VERB
admet-277	1	44	for	for	ADP
admet-277	1	45	log	log	NOUN
admet-277	1	46	p	p	PROPN
admet-277	1	47	measurement	measurement	NOUN
admet-277	1	48	zihao	zihao	PROPN
admet-277	1	49	song	song	PROPN
admet-277	1	50	,	,	PUNCT
admet-277	1	51	katsuhide	katsuhide	PROPN
admet-277	1	52	terada	terada	PROPN
admet-277	1	53	,	,	PUNCT
admet-277	1	54	kiyohiko	kiyohiko	PROPN
admet-277	1	55	sugano	sugano	PROPN
admet-277	1	56	*	*	PROPN
admet-277	1	57	department	department	PROPN
admet-277	1	58	of	of	ADP
admet-277	1	59	pharmaceutics	pharmaceutic	NOUN
admet-277	1	60	,	,	PUNCT
admet-277	1	61	faculty	faculty	NOUN
admet-277	1	62	of	of	ADP
admet-277	1	63	pharmaceutical	pharmaceutical	NOUN
admet-277	1	64	sciences	science	NOUN
admet-277	1	65	,	,	PUNCT
admet-277	1	66	toho	toho	NOUN
admet-277	1	67	university	university	NOUN
admet-277	1	68	,	,	PUNCT
admet-277	1	69	2	2	NUM
admet-277	1	70	-	-	SYM
admet-277	1	71	2	2	NUM
admet-277	1	72	-	-	PUNCT
admet-277	1	73	1	1	NUM
admet-277	1	74	,	,	PUNCT
admet-277	1	75	miyama	miyama	NOUN
admet-277	1	76	,	,	PUNCT
admet-277	1	77	funabashi	funabashi	PROPN
admet-277	1	78	,	,	PUNCT
admet-277	1	79	chiba	chiba	PROPN
admet-277	1	80	,	,	PUNCT
admet-277	1	81	274	274	NUM
admet-277	1	82	-	-	SYM
admet-277	1	83	8510	8510	NUM
admet-277	1	84	,	,	PUNCT
admet-277	1	85	japan	japan	PROPN
admet-277	1	86	*	*	PUNCT
admet-277	1	87	corresponding	correspond	VERB
admet-277	1	88	author	author	NOUN
admet-277	1	89	:	:	PUNCT
admet-277	2	1	e	e	NOUN
admet-277	2	2	-	-	NOUN
admet-277	2	3	mail	mail	NOUN
admet-277	2	4	:	:	PUNCT
admet-277	2	5	kiyohiko.sugano@phar.toho-u.ac.jp	kiyohiko.sugano@phar.toho-u.ac.jp	VERB
admet-277	2	6	;	;	PUNCT
admet-277	2	7	tel	tel	PROPN
admet-277	2	8	.	.	PROPN
admet-277	2	9	:	:	PUNCT
admet-277	3	1	+81	+81	NOUN
admet-277	3	2	47	47	NUM
admet-277	3	3	472	472	NUM
admet-277	3	4	1494	1494	NUM
admet-277	3	5	received	receive	VERB
admet-277	3	6	:	:	PUNCT
admet-277	3	7	march	march	PROPN
admet-277	3	8	17	17	NUM
admet-277	3	9	,	,	PUNCT
admet-277	3	10	2016	2016	NUM
admet-277	3	11	;	;	PUNCT
admet-277	3	12	published	publish	VERB
admet-277	3	13	:	:	PUNCT
admet-277	3	14	march	march	PROPN
admet-277	3	15	31	31	NUM
admet-277	3	16	,	,	PUNCT
admet-277	3	17	2016	2016	NUM
admet-277	3	18	abstract	abstract	NOUN
admet-277	3	19	a	a	DET
admet-277	3	20	reversed	reverse	VERB
admet-277	3	21	phase	phase	NOUN
admet-277	3	22	parallel	parallel	ADJ
admet-277	3	23	artificial	artificial	ADJ
admet-277	3	24	membrane	membrane	NOUN
admet-277	3	25	permeation	permeation	NOUN
admet-277	3	26	assay	assay	NOUN
admet-277	3	27	(	(	PUNCT
admet-277	3	28	rp	rp	NOUN
admet-277	3	29	-	-	PUNCT
admet-277	3	30	pampa	pampa	NOUN
admet-277	3	31	)	)	PUNCT
admet-277	3	32	was	be	AUX
admet-277	3	33	newly	newly	ADV
admet-277	3	34	invented	invent	VERB
admet-277	3	35	for	for	ADP
admet-277	3	36	log	log	NOUN
admet-277	3	37	p	p	PROPN
admet-277	3	38	measurement	measurement	NOUN
admet-277	3	39	.	.	PUNCT
admet-277	4	1	an	an	DET
admet-277	4	2	oil	oil	NOUN
admet-277	4	3	/	/	SYM
admet-277	4	4	water	water	NOUN
admet-277	4	5	/	/	SYM
admet-277	4	6	oil	oil	NOUN
admet-277	4	7	sandwich	sandwich	NOUN
admet-277	4	8	was	be	AUX
admet-277	4	9	constructed	construct	VERB
admet-277	4	10	using	use	VERB
admet-277	4	11	a	a	DET
admet-277	4	12	conventional	conventional	ADJ
admet-277	4	13	pampa	pampa	NOUN
admet-277	4	14	instrument	instrument	NOUN
admet-277	4	15	.	.	PUNCT
admet-277	5	1	1	1	NUM
admet-277	5	2	%	%	NOUN
admet-277	5	3	agarose	agarose	NOUN
admet-277	5	4	was	be	AUX
admet-277	5	5	used	use	VERB
admet-277	5	6	to	to	PART
admet-277	5	7	improve	improve	VERB
admet-277	5	8	the	the	DET
admet-277	5	9	physical	physical	ADJ
admet-277	5	10	stability	stability	NOUN
admet-277	5	11	of	of	ADP
admet-277	5	12	the	the	DET
admet-277	5	13	water	water	NOUN
admet-277	5	14	phase	phase	NOUN
admet-277	5	15	.	.	PUNCT
admet-277	6	1	a	a	DET
admet-277	6	2	linear	linear	ADJ
admet-277	6	3	correlation	correlation	NOUN
admet-277	6	4	between	between	ADP
admet-277	6	5	log	log	PROPN
admet-277	6	6	p	p	NOUN
admet-277	6	7	and	and	CCONJ
admet-277	6	8	the	the	DET
admet-277	6	9	apparent	apparent	ADJ
admet-277	6	10	permeability	permeability	NOUN
admet-277	6	11	was	be	AUX
admet-277	6	12	observed	observe	VERB
admet-277	6	13	in	in	ADP
admet-277	6	14	the	the	DET
admet-277	6	15	-0.24	-0.24	ADJ
admet-277	6	16	<	<	X
admet-277	6	17	log	log	NOUN
admet-277	6	18	p	p	X
admet-277	6	19	<	<	X
admet-277	6	20	2.85	2.85	NUM
admet-277	6	21	region	region	NOUN
admet-277	6	22	(	(	PUNCT
admet-277	6	23	r	r	NOUN
admet-277	6	24	2	2	NUM
admet-277	6	25	=	=	SYM
admet-277	6	26	0.98	0.98	NUM
admet-277	6	27	)	)	PUNCT
admet-277	6	28	.	.	PUNCT
admet-277	7	1	rp	rp	NOUN
admet-277	7	2	-	-	PUNCT
admet-277	7	3	pampa	pampa	PROPN
admet-277	7	4	was	be	AUX
admet-277	7	5	also	also	ADV
admet-277	7	6	applied	apply	VERB
admet-277	7	7	to	to	ADP
admet-277	7	8	pka	pka	PROPN
admet-277	7	9	measurement	measurement	NOUN
admet-277	7	10	.	.	PUNCT
admet-277	8	1	keywords	keyword	NOUN
admet-277	8	2	octanol	octanol	NOUN
admet-277	8	3	,	,	PUNCT
admet-277	8	4	partition	partition	NOUN
admet-277	8	5	,	,	PUNCT
admet-277	8	6	parallel	parallel	ADJ
admet-277	8	7	artificial	artificial	ADJ
admet-277	8	8	membrane	membrane	NOUN
admet-277	8	9	permeation	permeation	NOUN
admet-277	8	10	assay	assay	VERB
admet-277	8	11	,	,	PUNCT
admet-277	8	12	pka	pka	NOUN
admet-277	8	13	,	,	PUNCT
admet-277	8	14	drug	drug	NOUN
admet-277	8	15	introduction	introduction	NOUN
admet-277	8	16	high	high	ADJ
admet-277	8	17	throughput	throughput	NOUN
admet-277	8	18	physicochemical	physicochemical	ADJ
admet-277	8	19	profiling	profiling	NOUN
admet-277	8	20	of	of	ADP
admet-277	8	21	a	a	DET
admet-277	8	22	drug	drug	NOUN
admet-277	8	23	is	be	AUX
admet-277	8	24	still	still	ADV
admet-277	8	25	challenging	challenge	VERB
admet-277	8	26	in	in	ADP
admet-277	8	27	early	early	ADJ
admet-277	8	28	drug	drug	NOUN
admet-277	8	29	discovery	discovery	NOUN
admet-277	8	30	.	.	PUNCT
admet-277	9	1	various	various	ADJ
admet-277	9	2	methods	method	NOUN
admet-277	9	3	have	have	AUX
admet-277	9	4	been	be	AUX
admet-277	9	5	proposed	propose	VERB
admet-277	9	6	for	for	ADP
admet-277	9	7	octanol	octanol	NOUN
admet-277	9	8	–	–	PUNCT
admet-277	9	9	water	water	NOUN
admet-277	9	10	partition	partition	NOUN
admet-277	9	11	coefficient	coefficient	NOUN
admet-277	9	12	(	(	PUNCT
admet-277	9	13	log	log	VERB
admet-277	9	14	p	p	X
admet-277	9	15	)	)	PUNCT
admet-277	9	16	,	,	PUNCT
admet-277	9	17	solubility	solubility	NOUN
admet-277	9	18	,	,	PUNCT
admet-277	9	19	and	and	CCONJ
admet-277	9	20	pka	pka	NOUN
admet-277	9	21	measurements	measurement	NOUN
admet-277	9	22	[	[	X
admet-277	9	23	1	1	NUM
admet-277	9	24	]	]	PUNCT
admet-277	9	25	.	.	PUNCT
admet-277	10	1	the	the	DET
admet-277	10	2	parallel	parallel	ADJ
admet-277	10	3	artificial	artificial	ADJ
admet-277	10	4	membrane	membrane	NOUN
admet-277	10	5	permeation	permeation	NOUN
admet-277	10	6	assay	assay	NOUN
admet-277	10	7	(	(	PUNCT
admet-277	10	8	pampa	pampa	PROPN
admet-277	10	9	)	)	PUNCT
admet-277	10	10	has	have	AUX
admet-277	10	11	been	be	AUX
admet-277	10	12	widely	widely	ADV
admet-277	10	13	used	use	VERB
admet-277	10	14	in	in	ADP
admet-277	10	15	drug	drug	NOUN
admet-277	10	16	discovery	discovery	NOUN
admet-277	10	17	as	as	ADP
admet-277	10	18	pampa	pampa	NOUN
admet-277	10	19	is	be	AUX
admet-277	10	20	compatible	compatible	ADJ
admet-277	10	21	with	with	ADP
admet-277	10	22	high	high	ADJ
admet-277	10	23	throughput	throughput	NOUN
admet-277	10	24	screening	screening	NOUN
admet-277	10	25	(	(	PUNCT
admet-277	10	26	hts	hts	X
admet-277	10	27	)	)	PUNCT
admet-277	11	1	[	[	X
admet-277	11	2	2,3	2,3	NUM
admet-277	11	3	]	]	PUNCT
admet-277	11	4	.	.	PUNCT
admet-277	12	1	in	in	ADP
admet-277	12	2	normal	normal	ADJ
admet-277	12	3	phase	phase	NOUN
admet-277	12	4	(	(	PUNCT
admet-277	12	5	np-	np-	X
admet-277	12	6	)	)	PUNCT
admet-277	12	7	pampa	pampa	NOUN
admet-277	12	8	methods	method	NOUN
admet-277	12	9	,	,	PUNCT
admet-277	12	10	a	a	DET
admet-277	12	11	lipid	lipid	NOUN
admet-277	12	12	phase	phase	NOUN
admet-277	12	13	is	be	AUX
admet-277	12	14	immobilized	immobilize	VERB
admet-277	12	15	on	on	ADP
admet-277	12	16	a	a	DET
admet-277	12	17	filter	filter	NOUN
admet-277	12	18	(	(	PUNCT
admet-277	12	19	usually	usually	ADV
admet-277	12	20	a	a	DET
admet-277	12	21	96	96	NUM
admet-277	12	22	well	well	ADJ
admet-277	12	23	filter	filter	NOUN
admet-277	12	24	plate	plate	NOUN
admet-277	12	25	)	)	PUNCT
admet-277	12	26	and	and	CCONJ
admet-277	12	27	the	the	DET
admet-277	12	28	permeability	permeability	NOUN
admet-277	12	29	of	of	ADP
admet-277	12	30	a	a	DET
admet-277	12	31	drug	drug	NOUN
admet-277	12	32	across	across	ADP
admet-277	12	33	the	the	DET
admet-277	12	34	lipid	lipid	NOUN
admet-277	12	35	membrane	membrane	NOUN
admet-277	12	36	is	be	AUX
admet-277	12	37	measured	measure	VERB
admet-277	12	38	.	.	PUNCT
admet-277	13	1	previously	previously	ADV
admet-277	13	2	,	,	PUNCT
admet-277	13	3	faller	faller	NOUN
admet-277	13	4	et	et	PROPN
admet-277	13	5	al	al	PROPN
admet-277	13	6	.	.	PROPN
admet-277	13	7	applied	apply	VERB
admet-277	13	8	np	np	PROPN
admet-277	13	9	-	-	PUNCT
admet-277	13	10	pampa	pampa	NOUN
admet-277	13	11	to	to	PART
admet-277	13	12	log	log	VERB
admet-277	13	13	p	p	NOUN
admet-277	13	14	measurement	measurement	NOUN
admet-277	14	1	[	[	X
admet-277	14	2	4	4	NUM
admet-277	14	3	]	]	PUNCT
admet-277	14	4	.	.	PUNCT
admet-277	15	1	the	the	DET
admet-277	15	2	apparent	apparent	ADJ
admet-277	15	3	permeability	permeability	NOUN
admet-277	15	4	(	(	PUNCT
admet-277	15	5	papp	papp	NOUN
admet-277	15	6	)	)	PUNCT
admet-277	15	7	across	across	ADP
admet-277	15	8	the	the	DET
admet-277	15	9	octanol	octanol	NOUN
admet-277	15	10	impregnated	impregnate	VERB
admet-277	15	11	filter	filter	NOUN
admet-277	15	12	membrane	membrane	NOUN
admet-277	15	13	was	be	AUX
admet-277	15	14	found	find	VERB
admet-277	15	15	to	to	PART
admet-277	15	16	correlate	correlate	VERB
admet-277	15	17	with	with	ADP
admet-277	15	18	logp	logp	NOUN
admet-277	15	19	.	.	PUNCT
admet-277	16	1	however	however	ADV
admet-277	16	2	,	,	PUNCT
admet-277	16	3	the	the	DET
admet-277	16	4	papp	papp	NOUN
admet-277	16	5	–	–	PUNCT
admet-277	16	6	log	log	NOUN
admet-277	16	7	p	p	NOUN
admet-277	16	8	curve	curve	NOUN
admet-277	16	9	showed	show	VERB
admet-277	16	10	a	a	DET
admet-277	16	11	bell	bell	NOUN
admet-277	16	12	-	-	PUNCT
admet-277	16	13	shaped	shape	VERB
admet-277	16	14	relationship	relationship	NOUN
admet-277	16	15	with	with	ADP
admet-277	16	16	a	a	DET
admet-277	16	17	plateau	plateau	NOUN
admet-277	16	18	around	around	ADP
admet-277	16	19	log	log	NOUN
admet-277	16	20	p	p	NOUN
admet-277	16	21	=	=	NOUN
admet-277	16	22	1	1	X
admet-277	16	23	.	.	PUNCT
admet-277	17	1	therefore	therefore	ADV
admet-277	17	2	,	,	PUNCT
admet-277	17	3	it	it	PRON
admet-277	17	4	was	be	AUX
admet-277	17	5	impossible	impossible	ADJ
admet-277	17	6	to	to	PART
admet-277	17	7	estimate	estimate	VERB
admet-277	17	8	the	the	DET
admet-277	17	9	log	log	NOUN
admet-277	17	10	p	p	NOUN
admet-277	17	11	values	value	NOUN
admet-277	17	12	around	around	ADP
admet-277	17	13	log	log	NOUN
admet-277	17	14	p	p	NOUN
admet-277	17	15	=	=	NOUN
admet-277	17	16	1	1	X
admet-277	17	17	.	.	PUNCT
admet-277	17	18	a	a	DET
admet-277	17	19	bellshaped	bellshape	VERB
admet-277	17	20	relationship	relationship	NOUN
admet-277	17	21	between	between	ADP
admet-277	17	22	papp	papp	NOUN
admet-277	17	23	and	and	CCONJ
admet-277	17	24	lipophilicity	lipophilicity	NOUN
admet-277	17	25	of	of	ADP
admet-277	17	26	drugs	drug	NOUN
admet-277	17	27	is	be	AUX
admet-277	17	28	usually	usually	ADV
admet-277	17	29	observed	observe	VERB
admet-277	17	30	in	in	ADP
admet-277	17	31	np	np	NOUN
admet-277	17	32	-	-	NOUN
admet-277	17	33	pampa	pampa	NOUN
admet-277	17	34	[	[	X
admet-277	17	35	5	5	NUM
admet-277	17	36	]	]	PUNCT
admet-277	17	37	.	.	PUNCT
admet-277	18	1	the	the	DET
admet-277	18	2	purpose	purpose	NOUN
admet-277	18	3	of	of	ADP
admet-277	18	4	the	the	DET
admet-277	18	5	present	present	ADJ
admet-277	18	6	study	study	NOUN
admet-277	18	7	was	be	AUX
admet-277	18	8	to	to	PART
admet-277	18	9	overcome	overcome	VERB
admet-277	18	10	the	the	DET
admet-277	18	11	drawback	drawback	NOUN
admet-277	18	12	of	of	ADP
admet-277	18	13	np	np	NOUN
admet-277	18	14	-	-	NOUN
admet-277	18	15	pampa	pampa	NOUN
admet-277	18	16	for	for	ADP
admet-277	18	17	log	log	NOUN
admet-277	18	18	p	p	PROPN
admet-277	18	19	measurement	measurement	NOUN
admet-277	18	20	.	.	PUNCT
admet-277	19	1	a	a	DET
admet-277	19	2	reversed	reverse	VERB
admet-277	19	3	phase	phase	NOUN
admet-277	19	4	pampa	pampa	NOUN
admet-277	19	5	(	(	PUNCT
admet-277	19	6	rp	rp	NOUN
admet-277	19	7	-	-	PUNCT
admet-277	19	8	pampa	pampa	NOUN
admet-277	19	9	)	)	PUNCT
admet-277	19	10	method	method	NOUN
admet-277	19	11	for	for	ADP
admet-277	19	12	log	log	NOUN
admet-277	19	13	p	p	NOUN
admet-277	19	14	measurement	measurement	NOUN
admet-277	19	15	was	be	AUX
admet-277	19	16	newly	newly	ADV
admet-277	19	17	invented	invent	VERB
admet-277	19	18	.	.	PUNCT
admet-277	20	1	in	in	ADP
admet-277	20	2	rp	rp	NOUN
admet-277	20	3	-	-	PUNCT
admet-277	20	4	pampa	pampa	NOUN
admet-277	20	5	,	,	PUNCT
admet-277	20	6	an	an	DET
admet-277	20	7	oil	oil	NOUN
admet-277	20	8	/	/	SYM
admet-277	20	9	water	water	NOUN
admet-277	20	10	/	/	SYM
admet-277	20	11	oil	oil	NOUN
admet-277	20	12	sandwich	sandwich	NOUN
admet-277	20	13	was	be	AUX
admet-277	20	14	constructed	construct	VERB
admet-277	20	15	using	use	VERB
admet-277	20	16	a	a	DET
admet-277	20	17	conventional	conventional	ADJ
admet-277	20	18	pampa	pampa	NOUN
admet-277	20	19	instrument	instrument	NOUN
admet-277	20	20	(	(	PUNCT
admet-277	20	21	figure	figure	NOUN
admet-277	20	22	1	1	NUM
admet-277	20	23	)	)	PUNCT
admet-277	20	24	.	.	PUNCT
admet-277	21	1	in	in	ADP
admet-277	21	2	addition	addition	NOUN
admet-277	21	3	,	,	PUNCT
admet-277	21	4	rp	rp	NOUN
admet-277	21	5	-	-	PUNCT
admet-277	21	6	pampa	pampa	NOUN
admet-277	21	7	was	be	AUX
admet-277	21	8	applied	apply	VERB
admet-277	21	9	for	for	ADP
admet-277	21	10	pka	pka	PROPN
admet-277	21	11	measurement	measurement	NOUN
admet-277	21	12	,	,	PUNCT
admet-277	21	13	especially	especially	ADV
admet-277	21	14	for	for	ADP
admet-277	21	15	low	low	ADJ
admet-277	21	16	solubility	solubility	NOUN
admet-277	21	17	compounds	compound	NOUN
admet-277	21	18	.	.	PUNCT
admet-277	22	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-277	22	2	admet	admet	PROPN
admet-277	22	3	&	&	CCONJ
admet-277	22	4	dmpk	dmpk	PROPN
admet-277	22	5	4(1	4(1	NOUN
admet-277	22	6	)	)	PUNCT
admet-277	22	7	(	(	PUNCT
admet-277	22	8	2016	2016	NUM
admet-277	22	9	)	)	PUNCT
admet-277	22	10	54	54	NUM
admet-277	22	11	-	-	SYM
admet-277	22	12	59	59	NUM
admet-277	22	13	reversed	reverse	VERB
admet-277	22	14	phase	phase	NOUN
admet-277	22	15	pampa	pampa	NOUN
admet-277	22	16	doi	doi	PROPN
admet-277	22	17	:	:	PUNCT
admet-277	22	18	10.5599	10.5599	NUM
admet-277	22	19	/	/	SYM
admet-277	22	20	admet.4.1.277	admet.4.1.277	PROPN
admet-277	22	21	55	55	NUM
admet-277	22	22	figure	figure	NOUN
admet-277	22	23	1	1	NUM
admet-277	22	24	.	.	PUNCT
admet-277	22	25	schematic	schematic	ADJ
admet-277	22	26	configuration	configuration	NOUN
admet-277	22	27	of	of	ADP
admet-277	22	28	rp	rp	NOUN
admet-277	22	29	-	-	PUNCT
admet-277	22	30	pampa	pampa	NOUN
admet-277	22	31	materials	material	NOUN
admet-277	22	32	and	and	CCONJ
admet-277	22	33	methods	method	NOUN
admet-277	22	34	materials	material	NOUN
admet-277	22	35	octanol	octanol	NOUN
admet-277	22	36	,	,	PUNCT
admet-277	22	37	pentoxifylline	pentoxifylline	NOUN
admet-277	22	38	,	,	PUNCT
admet-277	22	39	1	1	NUM
admet-277	22	40	-	-	PUNCT
admet-277	22	41	naphthol	naphthol	NOUN
admet-277	22	42	,	,	PUNCT
admet-277	22	43	dipyridamole	dipyridamole	NOUN
admet-277	22	44	,	,	PUNCT
admet-277	22	45	and	and	CCONJ
admet-277	22	46	acid	acid	ADJ
admet-277	22	47	blue	blue	NOUN
admet-277	22	48	9	9	NUM
admet-277	22	49	were	be	AUX
admet-277	22	50	purchased	purchase	VERB
admet-277	22	51	from	from	ADP
admet-277	22	52	tokyo	tokyo	PROPN
admet-277	22	53	chemical	chemical	NOUN
admet-277	22	54	industry	industry	NOUN
admet-277	22	55	(	(	PUNCT
admet-277	22	56	tokyo	tokyo	PROPN
admet-277	22	57	,	,	PUNCT
admet-277	22	58	japan	japan	PROPN
admet-277	22	59	)	)	PUNCT
admet-277	22	60	.	.	PUNCT
admet-277	23	1	agar	agar	NOUN
admet-277	23	2	powder	powder	NOUN
admet-277	23	3	,	,	PUNCT
admet-277	23	4	agarose	agarose	NOUN
admet-277	23	5	s	s	PROPN
admet-277	23	6	,	,	PUNCT
admet-277	23	7	agarose	agarose	NOUN
admet-277	23	8	h	h	NOUN
admet-277	23	9	,	,	PUNCT
admet-277	23	10	prednisone	prednisone	NOUN
admet-277	23	11	,	,	PUNCT
admet-277	23	12	sulfamethoxazole	sulfamethoxazole	NOUN
admet-277	23	13	,	,	PUNCT
admet-277	23	14	carbamazepine	carbamazepine	NOUN
admet-277	23	15	,	,	PUNCT
admet-277	23	16	caffeine	caffeine	NOUN
admet-277	23	17	,	,	PUNCT
admet-277	23	18	chlormphenicol	chlormphenicol	ADV
admet-277	23	19	,	,	PUNCT
admet-277	23	20	ethanol	ethanol	NOUN
admet-277	23	21	,	,	PUNCT
admet-277	23	22	trisodium	trisodium	ADJ
admet-277	23	23	citrate	citrate	NOUN
admet-277	23	24	,	,	PUNCT
admet-277	23	25	sodium	sodium	NOUN
admet-277	23	26	dihydrogenphosphate	dihydrogenphosphate	NOUN
admet-277	23	27	,	,	PUNCT
admet-277	23	28	disodium	disodium	NOUN
admet-277	23	29	hydrogenphosphate	hydrogenphosphate	NOUN
admet-277	23	30	,	,	PUNCT
admet-277	23	31	sodium	sodium	NOUN
admet-277	23	32	hydroxide	hydroxide	NOUN
admet-277	23	33	solution	solution	NOUN
admet-277	23	34	,	,	PUNCT
admet-277	23	35	propranolol	propranolol	NOUN
admet-277	23	36	hydrochloride	hydrochloride	NOUN
admet-277	23	37	,	,	PUNCT
admet-277	23	38	warfarin	warfarin	NOUN
admet-277	23	39	sodium	sodium	NOUN
admet-277	23	40	,	,	PUNCT
admet-277	23	41	piroxicam	piroxicam	VERB
admet-277	23	42	,	,	PUNCT
admet-277	23	43	and	and	CCONJ
admet-277	23	44	ketoprofen	ketoprofen	NOUN
admet-277	23	45	were	be	AUX
admet-277	23	46	purchased	purchase	VERB
admet-277	23	47	from	from	ADP
admet-277	23	48	wako	wako	PROPN
admet-277	23	49	pure	pure	ADJ
admet-277	23	50	chemicals	chemical	NOUN
admet-277	23	51	(	(	PUNCT
admet-277	23	52	tokyo	tokyo	PROPN
admet-277	23	53	,	,	PUNCT
admet-277	23	54	japan	japan	PROPN
admet-277	23	55	)	)	PUNCT
admet-277	23	56	.	.	PUNCT
admet-277	24	1	phenacetin	phenacetin	PROPN
admet-277	24	2	was	be	AUX
admet-277	24	3	purchased	purchase	VERB
admet-277	24	4	from	from	ADP
admet-277	24	5	yamamoto	yamamoto	PROPN
admet-277	24	6	corporation	corporation	PROPN
admet-277	24	7	(	(	PUNCT
admet-277	24	8	osaka	osaka	PROPN
admet-277	24	9	,	,	PUNCT
admet-277	24	10	japan	japan	PROPN
admet-277	24	11	)	)	PUNCT
admet-277	24	12	.	.	PUNCT
admet-277	25	1	the	the	DET
admet-277	25	2	other	other	ADJ
admet-277	25	3	reagents	reagent	NOUN
admet-277	25	4	were	be	AUX
admet-277	25	5	of	of	ADP
admet-277	25	6	analytical	analytical	ADJ
admet-277	25	7	grade	grade	NOUN
admet-277	25	8	.	.	PUNCT
admet-277	26	1	papp	papp	PROPN
admet-277	26	2	measurement	measurement	VERB
admet-277	26	3	the	the	DET
admet-277	26	4	schematic	schematic	ADJ
admet-277	26	5	configuration	configuration	NOUN
admet-277	26	6	of	of	ADP
admet-277	26	7	rp	rp	NOUN
admet-277	26	8	-	-	PUNCT
admet-277	26	9	pampa	pampa	NOUN
admet-277	26	10	is	be	AUX
admet-277	26	11	shown	show	VERB
admet-277	26	12	in	in	ADP
admet-277	26	13	figure	figure	NOUN
admet-277	26	14	1	1	NUM
admet-277	26	15	.	.	PUNCT
admet-277	27	1	in	in	ADP
admet-277	27	2	rp	rp	NOUN
admet-277	27	3	-	-	PUNCT
admet-277	27	4	pampa	pampa	NOUN
admet-277	27	5	,	,	PUNCT
admet-277	27	6	the	the	DET
admet-277	27	7	water	water	NOUN
admet-277	27	8	phase	phase	NOUN
admet-277	27	9	(	(	PUNCT
admet-277	27	10	water	water	NOUN
admet-277	27	11	membrane	membrane	NOUN
admet-277	27	12	)	)	PUNCT
admet-277	27	13	was	be	AUX
admet-277	27	14	immobilized	immobilize	VERB
admet-277	27	15	on	on	ADP
admet-277	27	16	the	the	DET
admet-277	27	17	hydrophilic	hydrophilic	ADJ
admet-277	27	18	filter	filter	NOUN
admet-277	27	19	with	with	ADP
admet-277	27	20	the	the	DET
admet-277	27	21	aid	aid	NOUN
admet-277	27	22	of	of	ADP
admet-277	27	23	agarose	agarose	NOUN
admet-277	27	24	.	.	PUNCT
admet-277	28	1	agarose	agarose	NOUN
admet-277	28	2	s	s	VERB
admet-277	28	3	was	be	AUX
admet-277	28	4	dissolved	dissolve	VERB
admet-277	28	5	in	in	ADP
admet-277	28	6	hot	hot	ADJ
admet-277	28	7	water	water	NOUN
admet-277	28	8	or	or	CCONJ
admet-277	28	9	a	a	DET
admet-277	28	10	buffer	buffer	NOUN
admet-277	28	11	at	at	ADP
admet-277	28	12	1.0	1.0	NUM
admet-277	28	13	%	%	NOUN
admet-277	28	14	and	and	CCONJ
admet-277	28	15	then	then	ADV
admet-277	28	16	poured	pour	VERB
admet-277	28	17	into	into	ADP
admet-277	28	18	a	a	DET
admet-277	28	19	hydrophilic	hydrophilic	ADJ
admet-277	28	20	filter	filter	NOUN
admet-277	28	21	(	(	PUNCT
admet-277	28	22	multi	multi	NOUN
admet-277	28	23	screen	screen	NOUN
admet-277	28	24	-	-	PUNCT
admet-277	28	25	hv	hv	PROPN
admet-277	28	26	,	,	PUNCT
admet-277	28	27	pore	pore	ADJ
admet-277	28	28	size	size	NOUN
admet-277	28	29	0.48	0.48	NUM
admet-277	28	30	μm	μm	NOUN
admet-277	28	31	,	,	PUNCT
admet-277	28	32	low	low	ADJ
admet-277	28	33	protein	protein	NOUN
admet-277	28	34	binding	bind	VERB
admet-277	28	35	,	,	PUNCT
admet-277	28	36	millipore	millipore	PROPN
admet-277	28	37	)	)	PUNCT
admet-277	28	38	.	.	PUNCT
admet-277	29	1	a	a	DET
admet-277	29	2	model	model	NOUN
admet-277	29	3	drug	drug	NOUN
admet-277	29	4	was	be	AUX
admet-277	29	5	dissolved	dissolve	VERB
admet-277	29	6	in	in	ADP
admet-277	29	7	octanol	octanol	NOUN
admet-277	29	8	at	at	ADP
admet-277	29	9	10	10	NUM
admet-277	29	10	mm	mm	NOUN
admet-277	29	11	and	and	CCONJ
admet-277	29	12	added	add	VERB
admet-277	29	13	to	to	ADP
admet-277	29	14	the	the	DET
admet-277	29	15	donor	donor	NOUN
admet-277	29	16	plate	plate	NOUN
admet-277	29	17	(	(	PUNCT
admet-277	29	18	downside	downside	NOUN
admet-277	29	19	,	,	PUNCT
admet-277	29	20	300	300	NUM
admet-277	29	21	μl	μl	NUM
admet-277	29	22	)	)	PUNCT
admet-277	29	23	.	.	PUNCT
admet-277	30	1	the	the	DET
admet-277	30	2	filter	filter	NOUN
admet-277	30	3	plate	plate	NOUN
admet-277	30	4	was	be	AUX
admet-277	30	5	then	then	ADV
admet-277	30	6	put	put	VERB
admet-277	30	7	on	on	ADP
admet-277	30	8	the	the	DET
admet-277	30	9	donor	donor	NOUN
admet-277	30	10	plate	plate	NOUN
admet-277	30	11	.	.	PUNCT
admet-277	31	1	the	the	DET
admet-277	31	2	filter	filter	NOUN
admet-277	31	3	plate	plate	NOUN
admet-277	31	4	was	be	AUX
admet-277	31	5	filled	fill	VERB
admet-277	31	6	with	with	ADP
admet-277	31	7	200	200	NUM
admet-277	31	8	μl	μl	ADP
admet-277	31	9	of	of	ADP
admet-277	31	10	octanol	octanol	NOUN
admet-277	31	11	.	.	PUNCT
admet-277	32	1	after	after	ADP
admet-277	32	2	16	16	NUM
admet-277	32	3	hour	hour	NOUN
admet-277	32	4	incubation	incubation	NOUN
admet-277	32	5	at	at	ADP
admet-277	32	6	room	room	NOUN
admet-277	32	7	temperature	temperature	NOUN
admet-277	32	8	(	(	PUNCT
admet-277	32	9	25	25	NUM
admet-277	32	10	±	±	NUM
admet-277	32	11	1	1	NUM
admet-277	32	12	°	°	ADP
admet-277	32	13	c	c	NOUN
admet-277	32	14	)	)	PUNCT
admet-277	32	15	,	,	PUNCT
admet-277	32	16	both	both	DET
admet-277	32	17	octanol	octanol	NOUN
admet-277	32	18	phases	phase	NOUN
admet-277	32	19	were	be	AUX
admet-277	32	20	diluted	dilute	VERB
admet-277	32	21	tenfold	tenfold	ADV
admet-277	32	22	by	by	ADP
admet-277	32	23	ethanol	ethanol	NOUN
admet-277	32	24	and	and	CCONJ
admet-277	32	25	the	the	DET
admet-277	32	26	drug	drug	NOUN
admet-277	32	27	concentrations	concentration	NOUN
admet-277	32	28	in	in	ADP
admet-277	32	29	the	the	DET
admet-277	32	30	donor	donor	NOUN
admet-277	32	31	and	and	CCONJ
admet-277	32	32	accepter	accepter	NOUN
admet-277	32	33	sides	side	NOUN
admet-277	32	34	were	be	AUX
admet-277	32	35	measured	measure	VERB
admet-277	32	36	by	by	ADP
admet-277	32	37	uv	uv	NOUN
admet-277	32	38	spectroscopy	spectroscopy	NOUN
admet-277	32	39	.	.	PUNCT
admet-277	33	1	for	for	ADP
admet-277	33	2	pka	pka	PROPN
admet-277	33	3	measurement	measurement	NOUN
admet-277	33	4	sodium	sodium	NOUN
admet-277	33	5	phosphate	phosphate	NOUN
admet-277	33	6	and	and	CCONJ
admet-277	33	7	sodium	sodium	NOUN
admet-277	33	8	citric	citric	ADJ
admet-277	33	9	acid	acid	NOUN
admet-277	33	10	buffers	buffer	NOUN
admet-277	33	11	(	(	PUNCT
admet-277	33	12	100	100	NUM
admet-277	33	13	mm	mm	NOUN
admet-277	33	14	of	of	ADP
admet-277	33	15	anion	anion	NOUN
admet-277	33	16	species	specie	NOUN
admet-277	33	17	)	)	PUNCT
admet-277	33	18	were	be	AUX
admet-277	33	19	used	use	VERB
admet-277	33	20	to	to	PART
admet-277	33	21	construct	construct	VERB
admet-277	33	22	the	the	DET
admet-277	33	23	water	water	NOUN
admet-277	33	24	membrane	membrane	NOUN
admet-277	33	25	.	.	PUNCT
admet-277	34	1	papp	papp	PROPN
admet-277	34	2	was	be	AUX
admet-277	34	3	calculated	calculate	VERB
admet-277	34	4	as	as	SCONJ
admet-277	34	5	previously	previously	ADV
admet-277	34	6	reported	report	VERB
admet-277	34	7	[	[	X
admet-277	34	8	6	6	NUM
admet-277	34	9	]	]	PUNCT
admet-277	34	10	:	:	PUNCT
admet-277	34	11	c	c	NOUN
admet-277	34	12	c	c	NOUN
admet-277	34	13	p	p	NOUN
admet-277	34	14	a	a	DET
admet-277	34	15	v	v	NOUN
admet-277	34	16	v	v	ADP
admet-277	34	17	t	t	PROPN
admet-277	34	18	a	a	DET
admet-277	34	19	equilibrium	equilibrium	NOUN
admet-277	34	20	app	app	NOUN
admet-277	35	1	d	d	X
admet-277	35	2	a	a	DET
admet-277	35	3	ln(1	ln(1	NOUN
admet-277	35	4	/	/	SYM
admet-277	35	5	)	)	PUNCT
admet-277	35	6	(	(	PUNCT
admet-277	35	7	1	1	NUM
admet-277	35	8	/	/	SYM
admet-277	35	9	1/	1/	NUM
admet-277	35	10	)	)	PUNCT
admet-277	35	11			PROPN
admet-277	35	12			NOUN
admet-277	35	13			PROPN
admet-277	35	14			PROPN
admet-277	35	15			PROPN
admet-277	35	16			PROPN
admet-277	35	17	(	(	PUNCT
admet-277	35	18	1	1	NUM
admet-277	35	19	)	)	PUNCT
admet-277	35	20			NOUN
admet-277	35	21	c	c	PROPN
admet-277	35	22	c	c	NOUN
admet-277	35	23	v	v	ADP
admet-277	35	24	c	c	PROPN
admet-277	35	25	v	v	NUM
admet-277	35	26	v	v	NOUN
admet-277	35	27	vequilibrium	vequilibrium	NOUN
admet-277	35	28	d	d	PROPN
admet-277	35	29	d	d	PROPN
admet-277	35	30	a	a	DET
admet-277	35	31	a	a	PROPN
admet-277	35	32	d	d	X
admet-277	35	33	a/	a/	NOUN
admet-277	35	34	(	(	PUNCT
admet-277	35	35	)	)	PUNCT
admet-277	35	36			PROPN
admet-277	36	1			PROPN
admet-277	36	2			PROPN
admet-277	36	3			PROPN
admet-277	36	4			PROPN
admet-277	36	5	(	(	PUNCT
admet-277	36	6	2	2	X
admet-277	36	7	)	)	PUNCT
admet-277	36	8	where	where	SCONJ
admet-277	36	9	ca	can	AUX
admet-277	36	10	and	and	CCONJ
admet-277	36	11	cd	cd	PROPN
admet-277	36	12	are	be	AUX
admet-277	36	13	the	the	DET
admet-277	36	14	drug	drug	NOUN
admet-277	36	15	concentrations	concentration	NOUN
admet-277	36	16	in	in	ADP
admet-277	36	17	the	the	DET
admet-277	36	18	donor	donor	NOUN
admet-277	36	19	and	and	CCONJ
admet-277	36	20	acceptor	acceptor	NOUN
admet-277	36	21	phases	phase	NOUN
admet-277	36	22	at	at	ADP
admet-277	36	23	time	time	NOUN
admet-277	36	24	t	t	PROPN
admet-277	36	25	,	,	PUNCT
admet-277	36	26	respectively	respectively	ADV
admet-277	36	27	.	.	PUNCT
admet-277	37	1	vd	vd	NOUN
admet-277	37	2	and	and	CCONJ
admet-277	37	3	va	va	PROPN
admet-277	37	4	are	be	AUX
admet-277	37	5	the	the	DET
admet-277	37	6	volumes	volume	NOUN
admet-277	37	7	of	of	ADP
admet-277	37	8	the	the	DET
admet-277	37	9	donor	donor	NOUN
admet-277	37	10	and	and	CCONJ
admet-277	37	11	acceptor	acceptor	NOUN
admet-277	37	12	phases	phase	NOUN
admet-277	37	13	,	,	PUNCT
admet-277	37	14	respectively	respectively	ADV
admet-277	37	15	.	.	PUNCT
admet-277	38	1	a	a	PRON
admet-277	38	2	is	be	AUX
admet-277	38	3	the	the	DET
admet-277	38	4	membrane	membrane	NOUN
admet-277	38	5	surface	surface	NOUN
admet-277	38	6	area	area	NOUN
admet-277	38	7	(	(	PUNCT
admet-277	38	8	0.28	0.28	NUM
admet-277	38	9	cm2	cm2	NOUN
admet-277	38	10	)	)	PUNCT
admet-277	38	11	.	.	PUNCT
admet-277	39	1	results	result	VERB
admet-277	39	2	construction	construction	NOUN
admet-277	39	3	of	of	ADP
admet-277	39	4	rp	rp	NOUN
admet-277	39	5	-	-	PUNCT
admet-277	39	6	pampa	pampa	NOUN
admet-277	39	7	we	we	PRON
admet-277	39	8	first	first	ADV
admet-277	39	9	investigated	investigate	VERB
admet-277	39	10	the	the	DET
admet-277	39	11	stability	stability	NOUN
admet-277	39	12	of	of	ADP
admet-277	39	13	the	the	DET
admet-277	39	14	water	water	NOUN
admet-277	39	15	phase	phase	NOUN
admet-277	39	16	(	(	PUNCT
admet-277	39	17	water	water	NOUN
admet-277	39	18	membrane	membrane	NOUN
admet-277	39	19	)	)	PUNCT
admet-277	39	20	constructed	construct	VERB
admet-277	39	21	on	on	ADP
admet-277	39	22	the	the	DET
admet-277	39	23	hydrophilic	hydrophilic	PROPN
admet-277	39	24	z.	z.	PROPN
admet-277	39	25	song	song	PROPN
admet-277	39	26	et	et	PROPN
admet-277	39	27	al	al	PROPN
admet-277	39	28	.	.	PROPN
admet-277	39	29	admet	admet	PROPN
admet-277	39	30	&	&	CCONJ
admet-277	39	31	dmpk	dmpk	PROPN
admet-277	39	32	4(1	4(1	NOUN
admet-277	39	33	)	)	PUNCT
admet-277	39	34	(	(	PUNCT
admet-277	39	35	2016	2016	NUM
admet-277	39	36	)	)	PUNCT
admet-277	39	37	54	54	NUM
admet-277	39	38	-	-	SYM
admet-277	39	39	59	59	NUM
admet-277	39	40	56	56	NUM
admet-277	39	41	filter	filter	NOUN
admet-277	39	42	with	with	ADP
admet-277	39	43	the	the	DET
admet-277	39	44	aid	aid	NOUN
admet-277	39	45	of	of	ADP
admet-277	39	46	agarose	agarose	NOUN
admet-277	39	47	.	.	PUNCT
admet-277	40	1	1.0	1.0	NUM
admet-277	40	2	%	%	NOUN
admet-277	40	3	concentration	concentration	NOUN
admet-277	40	4	was	be	AUX
admet-277	40	5	selected	select	VERB
admet-277	40	6	to	to	PART
admet-277	40	7	enable	enable	VERB
admet-277	40	8	pipetting	pipetting	NOUN
admet-277	40	9	of	of	ADP
admet-277	40	10	the	the	DET
admet-277	40	11	hot	hot	ADJ
admet-277	40	12	sol	sol	NOUN
admet-277	40	13	phase	phase	NOUN
admet-277	40	14	while	while	SCONJ
admet-277	40	15	maintaining	maintain	VERB
admet-277	40	16	the	the	DET
admet-277	40	17	physical	physical	ADJ
admet-277	40	18	strength	strength	NOUN
admet-277	40	19	of	of	ADP
admet-277	40	20	the	the	DET
admet-277	40	21	agarose	agarose	NOUN
admet-277	40	22	gel	gel	NOUN
admet-277	40	23	.	.	PUNCT
admet-277	41	1	it	it	PRON
admet-277	41	2	was	be	AUX
admet-277	41	3	found	find	VERB
admet-277	41	4	that	that	SCONJ
admet-277	41	5	at	at	ADV
admet-277	41	6	least	least	ADV
admet-277	41	7	30	30	NUM
admet-277	41	8	μl	μl	NOUN
admet-277	41	9	of	of	ADP
admet-277	41	10	1	1	NUM
admet-277	41	11	%	%	NOUN
admet-277	41	12	agarose	agarose	NOUN
admet-277	41	13	was	be	AUX
admet-277	41	14	required	require	VERB
admet-277	41	15	to	to	PART
admet-277	41	16	provide	provide	VERB
admet-277	41	17	sufficient	sufficient	ADJ
admet-277	41	18	physical	physical	ADJ
admet-277	41	19	strength	strength	NOUN
admet-277	41	20	for	for	ADP
admet-277	41	21	papp	papp	NOUN
admet-277	41	22	measurement	measurement	NOUN
admet-277	41	23	.	.	PUNCT
admet-277	42	1	the	the	DET
admet-277	42	2	ager	ager	NOUN
admet-277	42	3	powder	powder	NOUN
admet-277	42	4	was	be	AUX
admet-277	42	5	found	find	VERB
admet-277	42	6	to	to	PART
admet-277	42	7	form	form	VERB
admet-277	42	8	a	a	DET
admet-277	42	9	less	less	ADV
admet-277	42	10	stable	stable	ADJ
admet-277	42	11	water	water	NOUN
admet-277	42	12	phase	phase	NOUN
admet-277	42	13	compared	compare	VERB
admet-277	42	14	to	to	ADP
admet-277	42	15	agarose	agarose	PROPN
admet-277	42	16	s	s	PROPN
admet-277	42	17	and	and	CCONJ
admet-277	42	18	h.	h.	PROPN
admet-277	42	19	in	in	ADP
admet-277	42	20	a	a	DET
admet-277	42	21	preliminary	preliminary	ADJ
admet-277	42	22	study	study	NOUN
admet-277	42	23	,	,	PUNCT
admet-277	42	24	it	it	PRON
admet-277	42	25	was	be	AUX
admet-277	42	26	found	find	VERB
admet-277	42	27	that	that	SCONJ
admet-277	42	28	more	more	ADJ
admet-277	42	29	than	than	ADP
admet-277	42	30	10	10	NUM
admet-277	42	31	hours	hour	NOUN
admet-277	42	32	were	be	AUX
admet-277	42	33	required	require	VERB
admet-277	42	34	to	to	PART
admet-277	42	35	achieve	achieve	VERB
admet-277	42	36	a	a	DET
admet-277	42	37	steady	steady	ADJ
admet-277	42	38	–	–	PUNCT
admet-277	42	39	state	state	NOUN
admet-277	42	40	flux	flux	NOUN
admet-277	42	41	across	across	ADP
admet-277	42	42	the	the	DET
admet-277	42	43	water	water	NOUN
admet-277	42	44	phase	phase	NOUN
admet-277	42	45	(	(	PUNCT
admet-277	42	46	data	datum	NOUN
admet-277	42	47	not	not	PART
admet-277	42	48	shown	show	VERB
admet-277	42	49	)	)	PUNCT
admet-277	42	50	.	.	PUNCT
admet-277	43	1	therefore	therefore	ADV
admet-277	43	2	,	,	PUNCT
admet-277	43	3	the	the	DET
admet-277	43	4	agarose	agarose	NOUN
admet-277	43	5	s	s	NOUN
admet-277	43	6	30	30	NUM
admet-277	43	7	μl	μl	ADP
admet-277	43	8	water	water	NOUN
admet-277	43	9	membrane	membrane	NOUN
admet-277	43	10	and	and	CCONJ
admet-277	43	11	16	16	NUM
admet-277	43	12	hour	hour	NOUN
admet-277	43	13	incubation	incubation	NOUN
admet-277	43	14	time	time	NOUN
admet-277	43	15	were	be	AUX
admet-277	43	16	employed	employ	VERB
admet-277	43	17	in	in	ADP
admet-277	43	18	the	the	DET
admet-277	43	19	following	follow	VERB
admet-277	43	20	studies	study	NOUN
admet-277	43	21	.	.	PUNCT
admet-277	44	1	log	log	PROPN
admet-277	44	2	papp	papp	PROPN
admet-277	44	3	–	–	PUNCT
admet-277	44	4	log	log	VERB
admet-277	44	5	p	p	NOUN
admet-277	44	6	relationship	relationship	NOUN
admet-277	44	7	the	the	DET
admet-277	44	8	log	log	NOUN
admet-277	44	9	papp	papp	NOUN
admet-277	44	10	and	and	CCONJ
admet-277	44	11	log	log	VERB
admet-277	44	12	p	p	NOUN
admet-277	44	13	data	datum	NOUN
admet-277	44	14	are	be	AUX
admet-277	44	15	summarized	summarize	VERB
admet-277	44	16	in	in	ADP
admet-277	44	17	table	table	NOUN
admet-277	44	18	1	1	NUM
admet-277	44	19	[	[	X
admet-277	44	20	1,7,8	1,7,8	NUM
admet-277	44	21	]	]	PUNCT
admet-277	44	22	.	.	PUNCT
admet-277	45	1	figure	figure	NOUN
admet-277	45	2	2	2	NUM
admet-277	45	3	shows	show	VERB
admet-277	45	4	the	the	DET
admet-277	45	5	correlation	correlation	NOUN
admet-277	45	6	between	between	ADP
admet-277	45	7	log	log	NOUN
admet-277	45	8	papp	papp	NOUN
admet-277	45	9	and	and	CCONJ
admet-277	45	10	log	log	VERB
admet-277	45	11	p.	p.	PROPN
admet-277	45	12	a	a	DET
admet-277	45	13	linear	linear	ADJ
admet-277	45	14	correlation	correlation	NOUN
admet-277	45	15	was	be	AUX
admet-277	45	16	observed	observe	VERB
admet-277	45	17	in	in	ADP
admet-277	45	18	the	the	DET
admet-277	45	19	-0.24	-0.24	ADJ
admet-277	45	20	<	<	X
admet-277	45	21	log	log	NOUN
admet-277	45	22	p	p	X
admet-277	45	23	<	<	X
admet-277	45	24	2.85	2.85	NUM
admet-277	45	25	region	region	NOUN
admet-277	45	26	(	(	PUNCT
admet-277	45	27	r2	r2	PROPN
admet-277	45	28	=	=	NOUN
admet-277	45	29	0.98	0.98	NUM
admet-277	45	30	)	)	PUNCT
admet-277	45	31	.	.	PUNCT
admet-277	46	1	the	the	DET
admet-277	46	2	slope	slope	NOUN
admet-277	46	3	of	of	ADP
admet-277	46	4	the	the	DET
admet-277	46	5	log	log	NOUN
admet-277	46	6	-	-	PUNCT
admet-277	46	7	log	log	NOUN
admet-277	46	8	plot	plot	NOUN
admet-277	46	9	was	be	AUX
admet-277	46	10	-0.48	-0.48	NOUN
admet-277	46	11	.	.	PUNCT
admet-277	46	12	table	table	NOUN
admet-277	46	13	1	1	NUM
admet-277	46	14	.	.	X
admet-277	46	15	papp	papp	NOUN
admet-277	46	16	and	and	CCONJ
admet-277	46	17	log	log	VERB
admet-277	46	18	p	p	NOUN
admet-277	46	19	drug	drug	NOUN
admet-277	46	20	log	log	NOUN
admet-277	46	21	p	p	X
admet-277	46	22	(	(	PUNCT
admet-277	46	23	literature)a	literature)a	PROPN
admet-277	46	24	log	log	PROPN
admet-277	46	25	papp	papp	NOUN
admet-277	46	26	(	(	PUNCT
admet-277	46	27	cm	cm	NOUN
admet-277	46	28	s-1	s-1	NOUN
admet-277	46	29	,	,	PUNCT
admet-277	46	30	mean	mean	PROPN
admet-277	46	31	±	±	NUM
admet-277	46	32	s.d	s.d	PROPN
admet-277	46	33	.	.	PROPN
admet-277	46	34	,	,	PUNCT
admet-277	46	35	n	n	NOUN
admet-277	46	36	=	=	SYM
admet-277	46	37	6	6	NUM
admet-277	46	38	)	)	PUNCT
admet-277	46	39	phenacetin	phenacetin	VERB
admet-277	46	40	1.58	1.58	NUM
admet-277	46	41	-6.38	-6.38	NUM
admet-277	46	42	±	±	NUM
admet-277	46	43	0.04	0.04	NUM
admet-277	46	44	caffeine	caffeine	NOUN
admet-277	46	45	0.10	0.10	NUM
admet-277	46	46	-5.53	-5.53	NOUN
admet-277	46	47	±	±	NUM
admet-277	46	48	0.02	0.02	NUM
admet-277	46	49	carbamazepine	carbamazepine	NOUN
admet-277	46	50	2.1	2.1	NUM
admet-277	46	51	-6.52	-6.52	NUM
admet-277	46	52	±	±	NUM
admet-277	46	53	0.04	0.04	NUM
admet-277	46	54	prednisone	prednisone	NOUN
admet-277	46	55	1.56	1.56	NUM
admet-277	46	56	-6.25	-6.25	NOUN
admet-277	46	57	±	±	NUM
admet-277	46	58	0.01	0.01	NUM
admet-277	46	59	chloramphenicol	chloramphenicol	NOUN
admet-277	46	60	1.14	1.14	NUM
admet-277	46	61	-6.13	-6.13	NUM
admet-277	46	62	±	±	NUM
admet-277	46	63	0.01	0.01	NUM
admet-277	46	64	sulfamethoxazole	sulfamethoxazole	NOUN
admet-277	46	65	0.70	0.70	NUM
admet-277	46	66	-5.96	-5.96	NUM
admet-277	46	67	±	±	NUM
admet-277	46	68	0.02	0.02	NUM
admet-277	46	69	1	1	NUM
admet-277	46	70	-	-	PUNCT
admet-277	46	71	naphthol	naphthol	NOUN
admet-277	46	72	2.85	2.85	NUM
admet-277	46	73	-6.95	-6.95	NUM
admet-277	46	74	±	±	NUM
admet-277	46	75	0.03	0.03	NUM
admet-277	46	76	pentoxifylline	pentoxifylline	NOUN
admet-277	47	1	0.38	0.38	NUM
admet-277	47	2	-5.78	-5.78	NUM
admet-277	47	3	±	±	NUM
admet-277	47	4	0.02	0.02	NUM
admet-277	47	5	a	a	DET
admet-277	47	6	refs	ref	NOUN
admet-277	47	7	.	.	PUNCT
admet-277	48	1	[	[	X
admet-277	48	2	1,7,8	1,7,8	NUM
admet-277	48	3	]	]	PUNCT
admet-277	48	4	figure	figure	NOUN
admet-277	48	5	2	2	NUM
admet-277	48	6	.	.	PUNCT
admet-277	48	7	log	log	PROPN
admet-277	48	8	p	p	NOUN
admet-277	48	9	–	–	PUNCT
admet-277	48	10	log	log	NOUN
admet-277	48	11	papp	papp	NOUN
admet-277	48	12	relationship	relationship	NOUN
admet-277	48	13	.	.	PUNCT
admet-277	49	1	ph	ph	PROPN
admet-277	49	2	papp	papp	NOUN
admet-277	49	3	profile	profile	VERB
admet-277	49	4	the	the	DET
admet-277	49	5	ph	ph	ADJ
admet-277	49	6	papp	papp	NOUN
admet-277	49	7	profiles	profile	NOUN
admet-277	49	8	were	be	AUX
admet-277	49	9	shown	show	VERB
admet-277	49	10	in	in	ADP
admet-277	49	11	figure	figure	NOUN
admet-277	49	12	3	3	NUM
admet-277	49	13	and	and	CCONJ
admet-277	49	14	table	table	NOUN
admet-277	49	15	2	2	NUM
admet-277	49	16	.	.	PUNCT
admet-277	50	1	the	the	DET
admet-277	50	2	pka	pka	PROPN
admet-277	50	3	values	value	NOUN
admet-277	50	4	were	be	AUX
admet-277	50	5	obtained	obtain	VERB
admet-277	50	6	as	as	ADP
admet-277	50	7	the	the	DET
admet-277	50	8	intersection	intersection	NOUN
admet-277	50	9	of	of	ADP
admet-277	50	10	the	the	DET
admet-277	50	11	slope	slope	NOUN
admet-277	50	12	and	and	CCONJ
admet-277	50	13	the	the	DET
admet-277	50	14	horizontal	horizontal	ADJ
admet-277	50	15	lines	line	NOUN
admet-277	50	16	.	.	PUNCT
admet-277	51	1	estimated	estimate	VERB
admet-277	51	2	and	and	CCONJ
admet-277	51	3	literature	literature	PROPN
admet-277	51	4	pka	pka	PROPN
admet-277	51	5	values	value	NOUN
admet-277	51	6	are	be	AUX
admet-277	51	7	shown	show	VERB
admet-277	51	8	in	in	ADP
admet-277	51	9	table	table	NOUN
admet-277	51	10	3	3	NUM
admet-277	51	11	[	[	X
admet-277	51	12	1,9	1,9	NUM
admet-277	51	13	]	]	PUNCT
admet-277	51	14	.	.	PUNCT
admet-277	52	1	y	y	NOUN
admet-277	52	2	=	=	PUNCT
admet-277	53	1	-0.4835x	-0.4835x	PROPN
admet-277	53	2	5.5584	5.5584	NUM
admet-277	53	3	r²	r²	NOUN
admet-277	53	4	=	=	SYM
admet-277	53	5	0.9842	0.9842	NUM
admet-277	53	6	-7.0	-7.0	PROPN
admet-277	53	7	-6.8	-6.8	NOUN
admet-277	53	8	-6.6	-6.6	NOUN
admet-277	53	9	-6.4	-6.4	VERB
admet-277	53	10	-6.2	-6.2	PROPN
admet-277	53	11	-6.0	-6.0	PROPN
admet-277	53	12	-5.8	-5.8	PROPN
admet-277	53	13	-5.6	-5.6	PROPN
admet-277	53	14	-5.4	-5.4	NOUN
admet-277	53	15	-5.2	-5.2	NOUN
admet-277	53	16	-5.0	-5.0	SYM
admet-277	53	17	0	0	NUM
admet-277	53	18	1	1	NUM
admet-277	53	19	2	2	NUM
admet-277	53	20	3	3	NUM
admet-277	53	21	lo	lo	NOUN
admet-277	53	22	gp	gp	NOUN
admet-277	54	1	ap	ap	PROPN
admet-277	55	1	p	p	X
admet-277	55	2	(	(	PUNCT
admet-277	55	3	cm	cm	PROPN
admet-277	55	4	/s	/s	NOUN
admet-277	55	5	ec	ec	PROPN
admet-277	55	6	)	)	PUNCT
admet-277	55	7	logp	logp	PROPN
admet-277	55	8	admet	admet	PROPN
admet-277	55	9	&	&	CCONJ
admet-277	55	10	dmpk	dmpk	PROPN
admet-277	55	11	4(1	4(1	NOUN
admet-277	55	12	)	)	PUNCT
admet-277	55	13	(	(	PUNCT
admet-277	55	14	2016	2016	NUM
admet-277	55	15	)	)	PUNCT
admet-277	55	16	54	54	NUM
admet-277	55	17	-	-	SYM
admet-277	55	18	59	59	NUM
admet-277	55	19	reversed	reverse	VERB
admet-277	55	20	phase	phase	NOUN
admet-277	55	21	pampa	pampa	NOUN
admet-277	55	22	doi	doi	PROPN
admet-277	55	23	:	:	PUNCT
admet-277	55	24	10.5599	10.5599	NUM
admet-277	55	25	/	/	SYM
admet-277	55	26	admet.4.1.277	admet.4.1.277	PROPN
admet-277	55	27	57	57	NUM
admet-277	55	28	figure	figure	NOUN
admet-277	55	29	3	3	NUM
admet-277	55	30	.	.	PUNCT
admet-277	55	31	ph	ph	ADJ
admet-277	55	32	–	–	PUNCT
admet-277	55	33	papp	papp	NOUN
admet-277	55	34	relationship	relationship	NOUN
admet-277	55	35	.	.	PUNCT
admet-277	56	1	mean	mean	PROPN
admet-277	56	2	±	±	NUM
admet-277	56	3	s.d	s.d	PROPN
admet-277	56	4	.	.	PUNCT
admet-277	57	1	n	n	PROPN
admet-277	57	2	=	=	SYM
admet-277	57	3	3	3	X
admet-277	57	4	.	.	NOUN
admet-277	57	5	table	table	NOUN
admet-277	57	6	2	2	NUM
admet-277	57	7	.	.	X
admet-277	57	8	papp	papp	NOUN
admet-277	57	9	of	of	ADP
admet-277	57	10	dissociable	dissociable	ADJ
admet-277	57	11	drugs	drug	NOUN
admet-277	57	12	at	at	ADP
admet-277	57	13	each	each	DET
admet-277	57	14	ph	ph	NOUN
admet-277	57	15	a	a	DET
admet-277	57	16	compound	compound	NOUN
admet-277	57	17	ph	ph	ADJ
admet-277	57	18	papp	papp	NOUN
admet-277	57	19	(	(	PUNCT
admet-277	57	20	10	10	NUM
admet-277	57	21	-	-	SYM
admet-277	57	22	6	6	NUM
admet-277	57	23	cm	cm	NOUN
admet-277	57	24	sec-1	sec-1	NOUN
admet-277	57	25	)	)	PUNCT
admet-277	57	26	compound	compound	NOUN
admet-277	57	27	ph	ph	ADJ
admet-277	57	28	papp	papp	NOUN
admet-277	57	29	(	(	PUNCT
admet-277	57	30	10	10	NUM
admet-277	57	31	-	-	SYM
admet-277	57	32	6	6	NUM
admet-277	57	33	cm	cm	NOUN
admet-277	57	34	sec-1	sec-1	NOUN
admet-277	57	35	)	)	PUNCT
admet-277	57	36	ketoprofen	ketoprofen	VERB
admet-277	57	37	3.1	3.1	NUM
admet-277	57	38	0.17	0.17	NUM
admet-277	57	39	±	±	NUM
admet-277	57	40	0.03	0.03	NUM
admet-277	57	41	dipyridamole	dipyridamole	NOUN
admet-277	57	42	3.9	3.9	NUM
admet-277	57	43	0.31	0.31	NUM
admet-277	57	44	±	±	NUM
admet-277	57	45	0.02	0.02	NUM
admet-277	57	46	(	(	PUNCT
admet-277	57	47	log	log	NOUN
admet-277	57	48	p	p	NOUN
admet-277	57	49	=	=	NOUN
admet-277	57	50	3.2	3.2	NUM
admet-277	57	51	)	)	PUNCT
admet-277	57	52	3.5	3.5	NUM
admet-277	57	53	0.17	0.17	NUM
admet-277	57	54	±	±	NUM
admet-277	57	55	0.07	0.07	NUM
admet-277	57	56	(	(	PUNCT
admet-277	57	57	log	log	NOUN
admet-277	57	58	p	p	NOUN
admet-277	57	59	=	=	NOUN
admet-277	57	60	3.9	3.9	NUM
admet-277	57	61	)	)	PUNCT
admet-277	57	62	4.5	4.5	NUM
admet-277	57	63	0.30	0.30	NUM
admet-277	57	64	±	±	NUM
admet-277	57	65	0.01	0.01	NUM
admet-277	57	66	4.1	4.1	NUM
admet-277	57	67	0.15	0.15	NUM
admet-277	57	68	±	±	NUM
admet-277	57	69	0.05	0.05	NUM
admet-277	57	70	5.1	5.1	NUM
admet-277	57	71	0.20	0.20	NUM
admet-277	57	72	±	±	NUM
admet-277	57	73	0.02	0.02	NUM
admet-277	57	74	4.5	4.5	NUM
admet-277	57	75	0.18	0.18	NUM
admet-277	57	76	±	±	NUM
admet-277	57	77	0.04	0.04	NUM
admet-277	57	78	5.5	5.5	NUM
admet-277	57	79	0.11	0.11	NUM
admet-277	57	80	±	±	NUM
admet-277	57	81	0.02	0.02	NUM
admet-277	57	82	5.0	5.0	NUM
admet-277	57	83	0.28	0.28	NUM
admet-277	57	84	±	±	NUM
admet-277	57	85	0.09	0.09	NUM
admet-277	57	86	5.9	5.9	NUM
admet-277	57	87	0.07	0.07	NUM
admet-277	57	88	±	±	NUM
admet-277	57	89	0.02	0.02	NUM
admet-277	57	90	5.5	5.5	NUM
admet-277	57	91	0.44	0.44	NUM
admet-277	57	92	±	±	NUM
admet-277	57	93	0.10	0.10	NUM
admet-277	57	94	6.5	6.5	NUM
admet-277	57	95	0.05	0.05	NUM
admet-277	57	96	±	±	NUM
admet-277	57	97	0.01	0.01	NUM
admet-277	57	98	6.0	6.0	NUM
admet-277	57	99	1.33	1.33	NUM
admet-277	57	100	±	±	NUM
admet-277	57	101	0.18	0.18	NUM
admet-277	57	102	7.0	7.0	NUM
admet-277	57	103	0.05	0.05	NUM
admet-277	57	104	±	±	NUM
admet-277	57	105	0.03	0.03	NUM
admet-277	57	106	6.5	6.5	NUM
admet-277	57	107	2.00	2.00	NUM
admet-277	57	108	±	±	NUM
admet-277	57	109	0.23	0.23	NUM
admet-277	57	110	7.5	7.5	NUM
admet-277	57	111	0.04	0.04	NUM
admet-277	57	112	±	±	NUM
admet-277	57	113	0.00	0.00	NUM
admet-277	57	114	piroxicam	piroxicam	NOUN
admet-277	57	115	3.0	3.0	NUM
admet-277	57	116	0.81	0.81	NUM
admet-277	57	117	±	±	NUM
admet-277	57	118	0.07	0.07	NUM
admet-277	57	119	propranolol	propranolol	NOUN
admet-277	57	120	8.0	8.0	NUM
admet-277	57	121	1.05	1.05	NUM
admet-277	57	122	±	±	NUM
admet-277	57	123	0.06	0.06	NUM
admet-277	57	124	(	(	PUNCT
admet-277	57	125	log	log	VERB
admet-277	57	126	p	p	NOUN
admet-277	57	127	=	=	NOUN
admet-277	57	128	2.0	2.0	NUM
admet-277	57	129	)	)	PUNCT
admet-277	57	130	3.5	3.5	NUM
admet-277	57	131	0.81	0.81	NUM
admet-277	57	132	±	±	NUM
admet-277	57	133	0.19	0.19	NUM
admet-277	57	134	(	(	PUNCT
admet-277	57	135	log	log	VERB
admet-277	57	136	p	p	NOUN
admet-277	57	137	=	=	NOUN
admet-277	57	138	2.9	2.9	NUM
admet-277	57	139	)	)	PUNCT
admet-277	57	140	8.5	8.5	NUM
admet-277	57	141	0.72	0.72	NUM
admet-277	57	142	±	±	NUM
admet-277	57	143	0.08	0.08	NUM
admet-277	57	144	4.0	4.0	NUM
admet-277	57	145	0.77	0.77	NUM
admet-277	57	146	±	±	NUM
admet-277	57	147	0.07	0.07	NUM
admet-277	57	148	9.0	9.0	NUM
admet-277	57	149	0.63	0.63	NUM
admet-277	57	150	±	±	NUM
admet-277	57	151	0.10	0.10	NUM
admet-277	57	152	4.5	4.5	NUM
admet-277	57	153	0.68	0.68	NUM
admet-277	57	154	±	±	NUM
admet-277	57	155	0.07	0.07	NUM
admet-277	57	156	9.5	9.5	NUM
admet-277	57	157	0.42	0.42	NUM
admet-277	57	158	±	±	NUM
admet-277	57	159	0.04	0.04	NUM
admet-277	57	160	5.0	5.0	NUM
admet-277	57	161	0.81	0.81	NUM
admet-277	57	162	±	±	NUM
admet-277	57	163	0.15	0.15	NUM
admet-277	57	164	10.0	10.0	NUM
admet-277	57	165	0.40	0.40	NUM
admet-277	57	166	±	±	NUM
admet-277	57	167	0.12	0.12	NUM
admet-277	57	168	5.5	5.5	NUM
admet-277	57	169	0.98	0.98	NUM
admet-277	57	170	±	±	NUM
admet-277	57	171	0.13	0.13	NUM
admet-277	57	172	10.5	10.5	NUM
admet-277	57	173	0.39	0.39	NUM
admet-277	57	174	±	±	NUM
admet-277	57	175	0.04	0.04	NUM
admet-277	57	176	6.0	6.0	NUM
admet-277	57	177	1.62	1.62	NUM
admet-277	57	178	±	±	NUM
admet-277	57	179	0.08	0.08	NUM
admet-277	57	180	11.0	11.0	NUM
admet-277	57	181	0.38	0.38	NUM
admet-277	57	182	±	±	NUM
admet-277	57	183	0.01	0.01	NUM
admet-277	57	184	6.5	6.5	NUM
admet-277	57	185	2.37	2.37	NUM
admet-277	57	186	±	±	NUM
admet-277	57	187	0.24	0.24	NUM
admet-277	57	188	11.5	11.5	NUM
admet-277	57	189	0.38	0.38	NUM
admet-277	57	190	±	±	NUM
admet-277	57	191	0.03	0.03	NUM
admet-277	57	192	warfarin	warfarin	NOUN
admet-277	57	193	3.0	3.0	NUM
admet-277	57	194	0.16	0.16	NUM
admet-277	57	195	±	±	NUM
admet-277	57	196	0.01	0.01	NUM
admet-277	57	197	(	(	PUNCT
admet-277	57	198	log	log	NOUN
admet-277	57	199	p	p	NOUN
admet-277	57	200	=	=	NOUN
admet-277	57	201	3.1	3.1	NUM
admet-277	57	202	)	)	PUNCT
admet-277	57	203	3.5	3.5	NUM
admet-277	57	204	0.16	0.16	NUM
admet-277	57	205	±	±	NUM
admet-277	57	206	0.01	0.01	NUM
admet-277	57	207	4.0	4.0	NUM
admet-277	57	208	0.16	0.16	NUM
admet-277	57	209	±	±	NUM
admet-277	57	210	0.02	0.02	NUM
admet-277	57	211	4.5	4.5	NUM
admet-277	57	212	0.23	0.23	NUM
admet-277	57	213	±	±	NUM
admet-277	57	214	0.02	0.02	NUM
admet-277	57	215	5.0	5.0	NUM
admet-277	57	216	0.22	0.22	NUM
admet-277	57	217	±	±	NUM
admet-277	57	218	0.04	0.04	NUM
admet-277	57	219	5.5	5.5	NUM
admet-277	57	220	0.23	0.23	NUM
admet-277	57	221	±	±	NUM
admet-277	57	222	0.02	0.02	NUM
admet-277	57	223	6.0	6.0	NUM
admet-277	57	224	0.34	0.34	NUM
admet-277	57	225	±	±	NUM
admet-277	57	226	0.04	0.04	NUM
admet-277	57	227	6.5	6.5	NUM
admet-277	57	228	0.80	0.80	NUM
admet-277	57	229	±	±	NUM
admet-277	57	230	0.05	0.05	NUM
admet-277	57	231	a	a	DET
admet-277	57	232	mean	mean	ADJ
admet-277	57	233	±	±	NUM
admet-277	57	234	s.d	s.d	PROPN
admet-277	57	235	.	.	PUNCT
admet-277	58	1	n	n	PROPN
admet-277	58	2	=	=	SYM
admet-277	58	3	3	3	X
admet-277	58	4	.	.	NUM
admet-277	58	5	measured	measure	VERB
admet-277	58	6	at	at	ADP
admet-277	58	7	25	25	NUM
admet-277	58	8	°	°	NOUN
admet-277	58	9	c	c	NOUN
admet-277	58	10	.	.	PUNCT
admet-277	59	1	the	the	DET
admet-277	59	2	buffer	buffer	NOUN
admet-277	59	3	concentration	concentration	NOUN
admet-277	59	4	was	be	AUX
admet-277	59	5	100	100	NUM
admet-277	59	6	mm	mm	NOUN
admet-277	59	7	.	.	PUNCT
admet-277	60	1	z.	z.	PROPN
admet-277	60	2	song	song	PROPN
admet-277	60	3	et	et	PROPN
admet-277	60	4	al	al	PROPN
admet-277	60	5	.	.	PROPN
admet-277	60	6	admet	admet	PROPN
admet-277	60	7	&	&	CCONJ
admet-277	60	8	dmpk	dmpk	PROPN
admet-277	60	9	4(1	4(1	NOUN
admet-277	60	10	)	)	PUNCT
admet-277	60	11	(	(	PUNCT
admet-277	60	12	2016	2016	NUM
admet-277	60	13	)	)	PUNCT
admet-277	60	14	54	54	NUM
admet-277	60	15	-	-	SYM
admet-277	60	16	59	59	NUM
admet-277	60	17	58	58	NUM
admet-277	60	18	table	table	NOUN
admet-277	60	19	3	3	NUM
admet-277	60	20	.	.	PUNCT
admet-277	61	1	pka	pka	PROPN
admet-277	61	2	values	value	NOUN
admet-277	61	3	drug	drug	VERB
admet-277	61	4	this	this	DET
admet-277	61	5	study	study	NOUN
admet-277	61	6	a	a	DET
admet-277	61	7	literatureb	literatureb	NOUN
admet-277	61	8	ketoprofen	ketoprofen	VERB
admet-277	61	9	4.9	4.9	NUM
admet-277	61	10	4.0	4.0	NUM
admet-277	61	11	piroxicam	piroxicam	NOUN
admet-277	61	12	4.8	4.8	NUM
admet-277	61	13	4.7	4.7	NUM
admet-277	61	14	warfarin	warfarin	NOUN
admet-277	61	15	5.7	5.7	NUM
admet-277	61	16	5.0	5.0	NUM
admet-277	61	17	dipyridamole	dipyridamole	NOUN
admet-277	61	18	5.9	5.9	NUM
admet-277	61	19	6.1	6.1	NUM
admet-277	61	20	propranolol	propranolol	NOUN
admet-277	61	21	9.4	9.4	NUM
admet-277	61	22	9.5	9.5	NUM
admet-277	61	23	a	a	DET
admet-277	61	24	measured	measure	VERB
admet-277	61	25	at	at	ADP
admet-277	61	26	25	25	NUM
admet-277	61	27	°	°	NOUN
admet-277	61	28	c	c	NOUN
admet-277	61	29	.	.	PUNCT
admet-277	62	1	the	the	DET
admet-277	62	2	buffer	buffer	NOUN
admet-277	62	3	concentration	concentration	NOUN
admet-277	62	4	was	be	AUX
admet-277	62	5	100	100	NUM
admet-277	62	6	mm	mm	NOUN
admet-277	62	7	.	.	PUNCT
admet-277	63	1	b	b	NOUN
admet-277	63	2	refs	ref	NOUN
admet-277	63	3	.	.	PUNCT
admet-277	64	1	[	[	X
admet-277	64	2	1	1	NUM
admet-277	64	3	]	]	PUNCT
admet-277	64	4	,	,	PUNCT
admet-277	64	5	[	[	X
admet-277	64	6	9	9	NUM
admet-277	64	7	]	]	PUNCT
admet-277	64	8	.	.	PUNCT
admet-277	65	1	discussion	discussion	NOUN
admet-277	65	2	in	in	ADP
admet-277	65	3	this	this	DET
admet-277	65	4	study	study	NOUN
admet-277	65	5	,	,	PUNCT
admet-277	65	6	rp	rp	NOUN
admet-277	65	7	-	-	NOUN
admet-277	65	8	pampa	pampa	NOUN
admet-277	65	9	for	for	ADP
admet-277	65	10	log	log	NOUN
admet-277	65	11	p	p	PROPN
admet-277	65	12	measurement	measurement	NOUN
admet-277	65	13	was	be	AUX
admet-277	65	14	investigated	investigate	VERB
admet-277	65	15	for	for	ADP
admet-277	65	16	the	the	DET
admet-277	65	17	first	first	ADJ
admet-277	65	18	time	time	NOUN
admet-277	65	19	.	.	PUNCT
admet-277	66	1	1.0	1.0	NUM
admet-277	66	2	%	%	NOUN
admet-277	66	3	agarose	agarose	NOUN
admet-277	66	4	was	be	AUX
admet-277	66	5	used	use	VERB
admet-277	66	6	to	to	PART
admet-277	66	7	improve	improve	VERB
admet-277	66	8	the	the	DET
admet-277	66	9	physical	physical	ADJ
admet-277	66	10	stability	stability	NOUN
admet-277	66	11	of	of	ADP
admet-277	66	12	the	the	DET
admet-277	66	13	water	water	NOUN
admet-277	66	14	membrane	membrane	NOUN
admet-277	66	15	.	.	PUNCT
admet-277	67	1	the	the	DET
admet-277	67	2	mesh	mesh	NOUN
admet-277	67	3	size	size	NOUN
admet-277	67	4	of	of	ADP
admet-277	67	5	agarose	agarose	NOUN
admet-277	67	6	is	be	AUX
admet-277	67	7	significantly	significantly	ADV
admet-277	67	8	larger	large	ADJ
admet-277	67	9	than	than	ADP
admet-277	67	10	the	the	DET
admet-277	67	11	size	size	NOUN
admet-277	67	12	of	of	ADP
admet-277	67	13	drug	drug	NOUN
admet-277	67	14	molecules	molecule	NOUN
admet-277	67	15	so	so	SCONJ
admet-277	67	16	that	that	SCONJ
admet-277	67	17	it	it	PRON
admet-277	67	18	does	do	AUX
admet-277	67	19	not	not	PART
admet-277	67	20	affect	affect	VERB
admet-277	67	21	the	the	DET
admet-277	67	22	diffusion	diffusion	NOUN
admet-277	67	23	coefficient	coefficient	NOUN
admet-277	67	24	of	of	ADP
admet-277	67	25	drugs	drug	NOUN
admet-277	67	26	[	[	X
admet-277	67	27	10	10	NUM
admet-277	67	28	]	]	PUNCT
admet-277	67	29	.	.	PUNCT
admet-277	68	1	by	by	ADP
admet-277	68	2	using	use	VERB
admet-277	68	3	rp	rp	NOUN
admet-277	68	4	-	-	PUNCT
admet-277	68	5	pampa	pampa	NOUN
admet-277	68	6	,	,	PUNCT
admet-277	68	7	log	log	VERB
admet-277	68	8	p	p	NOUN
admet-277	68	9	in	in	ADP
admet-277	68	10	the	the	DET
admet-277	68	11	-0.24	-0.24	ADJ
admet-277	68	12	<	<	X
admet-277	68	13	log	log	NOUN
admet-277	68	14	p	p	X
admet-277	68	15	<	<	X
admet-277	68	16	2.85	2.85	NUM
admet-277	68	17	range	range	NOUN
admet-277	68	18	can	can	AUX
admet-277	68	19	be	be	AUX
admet-277	68	20	accurately	accurately	ADV
admet-277	68	21	measured	measure	VERB
admet-277	68	22	.	.	PUNCT
admet-277	69	1	the	the	DET
admet-277	69	2	measurable	measurable	ADJ
admet-277	69	3	range	range	NOUN
admet-277	69	4	can	can	AUX
admet-277	69	5	be	be	AUX
admet-277	69	6	expanded	expand	VERB
admet-277	69	7	by	by	ADP
admet-277	69	8	using	use	VERB
admet-277	69	9	a	a	DET
admet-277	69	10	more	more	ADV
admet-277	69	11	sensitive	sensitive	ADJ
admet-277	69	12	quantitation	quantitation	NOUN
admet-277	69	13	method	method	NOUN
admet-277	69	14	such	such	ADJ
admet-277	69	15	as	as	ADP
admet-277	69	16	lc	lc	NOUN
admet-277	69	17	-	-	PUNCT
admet-277	69	18	ms	ms	NOUN
admet-277	69	19	.	.	PROPN
admet-277	70	1	the	the	DET
admet-277	70	2	slope	slope	NOUN
admet-277	70	3	of	of	ADP
admet-277	70	4	the	the	DET
admet-277	70	5	papp	papp	NOUN
admet-277	70	6	–	–	PUNCT
admet-277	70	7	log	log	NOUN
admet-277	70	8	p	p	NOUN
admet-277	70	9	relationship	relationship	NOUN
admet-277	70	10	was	be	AUX
admet-277	70	11	0.45	0.45	NUM
admet-277	70	12	,	,	PUNCT
admet-277	70	13	which	which	PRON
admet-277	70	14	is	be	AUX
admet-277	70	15	significantly	significantly	ADV
admet-277	70	16	smaller	small	ADJ
admet-277	70	17	than	than	ADP
admet-277	70	18	1	1	NUM
admet-277	70	19	.	.	PUNCT
admet-277	71	1	if	if	SCONJ
admet-277	71	2	papp	papp	NOUN
admet-277	71	3	follows	follow	VERB
admet-277	71	4	the	the	DET
admet-277	71	5	solubility	solubility	NOUN
admet-277	71	6	–	–	PUNCT
admet-277	71	7	partition	partition	NOUN
admet-277	71	8	theory	theory	NOUN
admet-277	71	9	for	for	ADP
admet-277	71	10	membrane	membrane	NOUN
admet-277	71	11	permeation	permeation	NOUN
admet-277	71	12	,	,	PUNCT
admet-277	71	13	i.e.	i.e.	X
admet-277	71	14	,	,	PUNCT
admet-277	71	15	papp	papp	NOUN
admet-277	71	16	=	=	SYM
admet-277	71	17	pd	pd	PROPN
admet-277	71	18	/	/	SYM
admet-277	71	19	h	h	PROPN
admet-277	71	20	where	where	SCONJ
admet-277	71	21	d	d	NOUN
admet-277	71	22	is	be	AUX
admet-277	71	23	the	the	DET
admet-277	71	24	diffusion	diffusion	NOUN
admet-277	71	25	coefficient	coefficient	NOUN
admet-277	71	26	and	and	CCONJ
admet-277	71	27	h	h	NOUN
admet-277	71	28	is	be	AUX
admet-277	71	29	the	the	DET
admet-277	71	30	thickness	thickness	NOUN
admet-277	71	31	of	of	ADP
admet-277	71	32	the	the	DET
admet-277	71	33	membrane	membrane	NOUN
admet-277	71	34	,	,	PUNCT
admet-277	71	35	the	the	DET
admet-277	71	36	slope	slope	NOUN
admet-277	71	37	of	of	ADP
admet-277	71	38	the	the	DET
admet-277	71	39	log	log	NOUN
admet-277	71	40	-	-	PUNCT
admet-277	71	41	log	log	NOUN
admet-277	71	42	plot	plot	NOUN
admet-277	71	43	should	should	AUX
admet-277	71	44	be	be	AUX
admet-277	71	45	unity	unity	NOUN
admet-277	71	46	[	[	X
admet-277	71	47	11	11	NUM
admet-277	71	48	]	]	PUNCT
admet-277	71	49	.	.	PUNCT
admet-277	72	1	the	the	DET
admet-277	72	2	reason	reason	NOUN
admet-277	72	3	for	for	ADP
admet-277	72	4	this	this	DET
admet-277	72	5	deviation	deviation	NOUN
admet-277	72	6	is	be	AUX
admet-277	72	7	not	not	PART
admet-277	72	8	clear	clear	ADJ
admet-277	72	9	.	.	PUNCT
admet-277	73	1	previously	previously	ADV
admet-277	73	2	,	,	PUNCT
admet-277	73	3	kwon	kwon	AUX
admet-277	73	4	et	et	PROPN
admet-277	73	5	al	al	PROPN
admet-277	73	6	.	.	PROPN
admet-277	73	7	reported	report	VERB
admet-277	73	8	a	a	DET
admet-277	73	9	poly(dimethylsiloxane)(pdms	poly(dimethylsiloxane)(pdms	PROPN
admet-277	73	10	)	)	PUNCT
admet-277	73	11	permeation	permeation	NOUN
admet-277	73	12	assay	assay	PROPN
admet-277	73	13	,	,	PUNCT
admet-277	73	14	which	which	PRON
admet-277	73	15	might	might	AUX
admet-277	73	16	be	be	AUX
admet-277	73	17	regarded	regard	VERB
admet-277	73	18	as	as	ADP
admet-277	73	19	a	a	DET
admet-277	73	20	kind	kind	NOUN
admet-277	73	21	of	of	ADP
admet-277	73	22	reversed	reverse	VERB
admet-277	73	23	phase	phase	NOUN
admet-277	73	24	membrane	membrane	NOUN
admet-277	73	25	permeation	permeation	NOUN
admet-277	73	26	assay	assay	VERB
admet-277	74	1	[	[	X
admet-277	74	2	12	12	NUM
admet-277	74	3	]	]	PUNCT
admet-277	74	4	.	.	PUNCT
admet-277	75	1	however	however	ADV
admet-277	75	2	,	,	PUNCT
admet-277	75	3	the	the	DET
admet-277	75	4	configuration	configuration	NOUN
admet-277	75	5	of	of	ADP
admet-277	75	6	the	the	DET
admet-277	75	7	pdms	pdms	ADJ
admet-277	75	8	permeation	permeation	NOUN
admet-277	75	9	assay	assay	NOUN
admet-277	75	10	was	be	AUX
admet-277	75	11	largely	largely	ADV
admet-277	75	12	different	different	ADJ
admet-277	75	13	from	from	ADP
admet-277	75	14	the	the	DET
admet-277	75	15	one	one	NOUN
admet-277	75	16	used	use	VERB
admet-277	75	17	in	in	ADP
admet-277	75	18	the	the	DET
admet-277	75	19	present	present	ADJ
admet-277	75	20	study	study	NOUN
admet-277	75	21	that	that	PRON
admet-277	75	22	is	be	AUX
admet-277	75	23	usually	usually	ADV
admet-277	75	24	referred	refer	VERB
admet-277	75	25	as	as	ADP
admet-277	75	26	pampa	pampa	NOUN
admet-277	75	27	.	.	PUNCT
admet-277	76	1	in	in	ADP
admet-277	76	2	the	the	DET
admet-277	76	3	pdms	pdms	ADJ
admet-277	76	4	permeation	permeation	NOUN
admet-277	76	5	assay	assay	VERB
admet-277	76	6	,	,	PUNCT
admet-277	76	7	a	a	DET
admet-277	76	8	side	side	NOUN
admet-277	76	9	-	-	PUNCT
admet-277	76	10	by	by	ADP
admet-277	76	11	-	-	PUNCT
admet-277	76	12	side	side	ADJ
admet-277	76	13	single	single	ADJ
admet-277	76	14	diffusion	diffusion	NOUN
admet-277	76	15	chamber	chamber	PROPN
admet-277	76	16	was	be	AUX
admet-277	76	17	employed	employ	VERB
admet-277	76	18	.	.	PUNCT
admet-277	77	1	a	a	DET
admet-277	77	2	pdms	pdms	ADJ
admet-277	77	3	membrane	membrane	NOUN
admet-277	77	4	was	be	AUX
admet-277	77	5	put	put	VERB
admet-277	77	6	between	between	ADP
admet-277	77	7	two	two	NUM
admet-277	77	8	chambers	chamber	NOUN
admet-277	77	9	filled	fill	VERB
admet-277	77	10	with	with	ADP
admet-277	77	11	aqueous	aqueous	ADJ
admet-277	77	12	bulk	bulk	ADJ
admet-277	77	13	fluids	fluid	NOUN
admet-277	77	14	.	.	PUNCT
admet-277	78	1	in	in	ADP
admet-277	78	2	addition	addition	NOUN
admet-277	78	3	,	,	PUNCT
admet-277	78	4	pdms	pdms	ADJ
admet-277	78	5	disks	disk	NOUN
admet-277	78	6	were	be	AUX
admet-277	78	7	added	add	VERB
admet-277	78	8	to	to	ADP
admet-277	78	9	both	both	CCONJ
admet-277	78	10	the	the	DET
admet-277	78	11	donor	donor	NOUN
admet-277	78	12	and	and	CCONJ
admet-277	78	13	acceptor	acceptor	NOUN
admet-277	78	14	sides	side	NOUN
admet-277	78	15	as	as	ADP
admet-277	78	16	dosing	dose	VERB
admet-277	78	17	and	and	CCONJ
admet-277	78	18	sampling	sample	VERB
admet-277	78	19	(	(	PUNCT
admet-277	78	20	extracting	extract	VERB
admet-277	78	21	)	)	PUNCT
admet-277	78	22	phases	phase	NOUN
admet-277	78	23	,	,	PUNCT
admet-277	78	24	respectively	respectively	ADV
admet-277	78	25	.	.	PUNCT
admet-277	79	1	the	the	DET
admet-277	79	2	aqueous	aqueous	ADJ
admet-277	79	3	phases	phase	NOUN
admet-277	79	4	were	be	AUX
admet-277	79	5	stirred	stir	VERB
admet-277	79	6	by	by	ADP
admet-277	79	7	magnetic	magnetic	ADJ
admet-277	79	8	stirrers	stirrer	NOUN
admet-277	79	9	.	.	PUNCT
admet-277	80	1	in	in	ADP
admet-277	80	2	the	the	DET
admet-277	80	3	pdms	pdms	ADJ
admet-277	80	4	permeation	permeation	NOUN
admet-277	80	5	assay	assay	VERB
admet-277	80	6	,	,	PUNCT
admet-277	80	7	a	a	DET
admet-277	80	8	good	good	ADJ
admet-277	80	9	correlation	correlation	NOUN
admet-277	80	10	was	be	AUX
admet-277	80	11	observed	observe	VERB
admet-277	80	12	between	between	ADP
admet-277	80	13	log	log	NOUN
admet-277	80	14	papp	papp	NOUN
admet-277	80	15	and	and	CCONJ
admet-277	80	16	log	log	VERB
admet-277	80	17	p	p	NOUN
admet-277	80	18	in	in	ADP
admet-277	80	19	the	the	DET
admet-277	80	20	range	range	NOUN
admet-277	80	21	of	of	ADP
admet-277	80	22	log	log	NOUN
admet-277	80	23	p	p	PROPN
admet-277	80	24	>	>	X
admet-277	80	25	3	3	NUM
admet-277	80	26	even	even	ADV
admet-277	80	27	though	though	SCONJ
admet-277	80	28	pdms	pdm	NOUN
admet-277	80	29	was	be	AUX
admet-277	80	30	used	use	VERB
admet-277	80	31	instead	instead	ADV
admet-277	80	32	of	of	ADP
admet-277	80	33	octanol	octanol	NOUN
admet-277	80	34	as	as	ADP
admet-277	80	35	the	the	DET
admet-277	80	36	oil	oil	NOUN
admet-277	80	37	phase	phase	NOUN
admet-277	80	38	.	.	PUNCT
admet-277	81	1	for	for	ADP
admet-277	81	2	low	low	ADJ
admet-277	81	3	solubility	solubility	NOUN
admet-277	81	4	drugs	drug	NOUN
admet-277	81	5	,	,	PUNCT
admet-277	81	6	it	it	PRON
admet-277	81	7	has	have	AUX
admet-277	81	8	been	be	AUX
admet-277	81	9	difficult	difficult	ADJ
admet-277	81	10	to	to	PART
admet-277	81	11	measure	measure	VERB
admet-277	81	12	pka	pka	PROPN
admet-277	81	13	by	by	ADP
admet-277	81	14	using	use	VERB
admet-277	81	15	conventional	conventional	ADJ
admet-277	81	16	methods	method	NOUN
admet-277	81	17	such	such	ADJ
admet-277	81	18	as	as	ADP
admet-277	81	19	ph	ph	ADJ
admet-277	81	20	titration	titration	NOUN
admet-277	81	21	.	.	PUNCT
admet-277	82	1	the	the	DET
admet-277	82	2	ph	ph	PROPN
admet-277	82	3	–	–	PUNCT
admet-277	82	4	solubility	solubility	NOUN
admet-277	82	5	profile	profile	NOUN
admet-277	82	6	can	can	AUX
admet-277	82	7	be	be	AUX
admet-277	82	8	used	use	VERB
admet-277	82	9	to	to	PART
admet-277	82	10	estimate	estimate	VERB
admet-277	82	11	pka	pka	PROPN
admet-277	82	12	for	for	ADP
admet-277	82	13	low	low	ADJ
admet-277	82	14	solubility	solubility	NOUN
admet-277	82	15	drugs	drug	NOUN
admet-277	82	16	[	[	X
admet-277	82	17	13,14	13,14	NUM
admet-277	82	18	]	]	PUNCT
admet-277	82	19	.	.	PUNCT
admet-277	83	1	however	however	ADV
admet-277	83	2	,	,	PUNCT
admet-277	83	3	this	this	DET
admet-277	83	4	method	method	NOUN
admet-277	83	5	may	may	AUX
admet-277	83	6	not	not	PART
admet-277	83	7	be	be	AUX
admet-277	83	8	accurate	accurate	ADJ
admet-277	83	9	due	due	ADJ
admet-277	83	10	to	to	PART
admet-277	83	11	aggregate	aggregate	VERB
admet-277	83	12	formation	formation	NOUN
admet-277	83	13	,	,	PUNCT
admet-277	83	14	low	low	ADJ
admet-277	83	15	detection	detection	NOUN
admet-277	83	16	limit	limit	NOUN
admet-277	83	17	,	,	PUNCT
admet-277	83	18	etc	etc	X
admet-277	83	19	.	.	X
admet-277	83	20	in	in	ADP
admet-277	83	21	rp	rp	NOUN
admet-277	83	22	-	-	PUNCT
admet-277	83	23	pampa	pampa	NOUN
admet-277	83	24	,	,	PUNCT
admet-277	83	25	a	a	DET
admet-277	83	26	drug	drug	NOUN
admet-277	83	27	is	be	AUX
admet-277	83	28	solubilized	solubilize	VERB
admet-277	83	29	in	in	ADP
admet-277	83	30	the	the	DET
admet-277	83	31	organic	organic	ADJ
admet-277	83	32	solvent	solvent	NOUN
admet-277	83	33	phase	phase	NOUN
admet-277	83	34	.	.	PUNCT
admet-277	84	1	therefore	therefore	ADV
admet-277	84	2	,	,	PUNCT
admet-277	84	3	it	it	PRON
admet-277	84	4	would	would	AUX
admet-277	84	5	become	become	VERB
admet-277	84	6	possible	possible	ADJ
admet-277	84	7	to	to	PART
admet-277	84	8	measure	measure	VERB
admet-277	84	9	pka	pka	PROPN
admet-277	84	10	for	for	ADP
admet-277	84	11	low	low	ADJ
admet-277	84	12	solubility	solubility	NOUN
admet-277	84	13	drugs	drug	NOUN
admet-277	84	14	by	by	ADP
admet-277	84	15	using	use	VERB
admet-277	84	16	rp	rp	NOUN
admet-277	84	17	-	-	PUNCT
admet-277	84	18	pampa	pampa	NOUN
admet-277	84	19	.	.	PUNCT
admet-277	85	1	as	as	SCONJ
admet-277	85	2	the	the	DET
admet-277	85	3	ph	ph	NOUN
admet-277	85	4	of	of	ADP
admet-277	85	5	the	the	DET
admet-277	85	6	water	water	NOUN
admet-277	85	7	membrane	membrane	NOUN
admet-277	85	8	was	be	AUX
admet-277	85	9	changed	change	VERB
admet-277	85	10	in	in	ADP
admet-277	85	11	rp	rp	NOUN
admet-277	85	12	-	-	PUNCT
admet-277	85	13	pampa	pampa	NOUN
admet-277	85	14	,	,	PUNCT
admet-277	85	15	the	the	DET
admet-277	85	16	ph	ph	ADJ
admet-277	85	17	–	–	PUNCT
admet-277	85	18	papp	papp	NOUN
admet-277	85	19	relationship	relationship	NOUN
admet-277	85	20	should	should	AUX
admet-277	85	21	become	become	VERB
admet-277	85	22	a	a	DET
admet-277	85	23	mirror	mirror	NOUN
admet-277	85	24	image	image	NOUN
admet-277	85	25	of	of	ADP
admet-277	85	26	that	that	PRON
admet-277	85	27	for	for	ADP
admet-277	85	28	np	np	NOUN
admet-277	85	29	-	-	PUNCT
admet-277	85	30	pampa	pampa	NOUN
admet-277	85	31	.	.	PUNCT
admet-277	86	1	however	however	ADV
admet-277	86	2	,	,	PUNCT
admet-277	86	3	the	the	DET
admet-277	86	4	ph	ph	ADJ
admet-277	86	5	–	–	PUNCT
admet-277	86	6	papp	papp	NOUN
admet-277	86	7	relationship	relationship	NOUN
admet-277	86	8	deviated	deviate	VERB
admet-277	86	9	from	from	ADP
admet-277	86	10	the	the	DET
admet-277	86	11	henderson	henderson	PROPN
admet-277	86	12	–	–	PUNCT
admet-277	86	13	hasselbalch	hasselbalch	PROPN
admet-277	86	14	equation	equation	NOUN
admet-277	86	15	.	.	PUNCT
admet-277	87	1	therefore	therefore	ADV
admet-277	87	2	,	,	PUNCT
admet-277	87	3	the	the	DET
admet-277	87	4	pka	pka	PROPN
admet-277	87	5	values	value	NOUN
admet-277	87	6	of	of	ADP
admet-277	87	7	the	the	DET
admet-277	87	8	model	model	NOUN
admet-277	87	9	drugs	drug	NOUN
admet-277	87	10	were	be	AUX
admet-277	87	11	estimated	estimate	VERB
admet-277	87	12	as	as	ADP
admet-277	87	13	the	the	DET
admet-277	87	14	intersection	intersection	NOUN
admet-277	87	15	of	of	ADP
admet-277	87	16	the	the	DET
admet-277	87	17	slope	slope	NOUN
admet-277	87	18	and	and	CCONJ
admet-277	87	19	the	the	DET
admet-277	87	20	horizontal	horizontal	ADJ
admet-277	87	21	lines	line	NOUN
admet-277	87	22	.	.	PUNCT
admet-277	88	1	the	the	DET
admet-277	88	2	pka	pka	PROPN
admet-277	88	3	values	value	NOUN
admet-277	88	4	of	of	ADP
admet-277	88	5	acidic	acidic	ADJ
admet-277	88	6	drugs	drug	NOUN
admet-277	88	7	were	be	AUX
admet-277	88	8	underestimated	underestimate	VERB
admet-277	88	9	by	by	ADP
admet-277	88	10	the	the	DET
admet-277	88	11	rp	rp	NOUN
admet-277	88	12	-	-	PUNCT
admet-277	88	13	pampa	pampa	NOUN
admet-277	88	14	method	method	NOUN
admet-277	88	15	.	.	PUNCT
admet-277	89	1	the	the	DET
admet-277	89	2	reason	reason	NOUN
admet-277	89	3	for	for	ADP
admet-277	89	4	this	this	DET
admet-277	89	5	deviation	deviation	NOUN
admet-277	89	6	is	be	AUX
admet-277	89	7	not	not	PART
admet-277	89	8	clear	clear	ADJ
admet-277	89	9	.	.	PUNCT
admet-277	90	1	one	one	NUM
admet-277	90	2	possible	possible	ADJ
admet-277	90	3	reason	reason	NOUN
admet-277	90	4	may	may	AUX
admet-277	90	5	be	be	AUX
admet-277	90	6	that	that	SCONJ
admet-277	90	7	the	the	DET
admet-277	90	8	incubation	incubation	NOUN
admet-277	90	9	time	time	NOUN
admet-277	90	10	of	of	ADP
admet-277	90	11	16	16	NUM
admet-277	90	12	hours	hour	NOUN
admet-277	90	13	might	might	AUX
admet-277	90	14	not	not	PART
admet-277	90	15	be	be	AUX
admet-277	90	16	sufficient	sufficient	ADJ
admet-277	90	17	to	to	PART
admet-277	90	18	achieve	achieve	VERB
admet-277	90	19	a	a	DET
admet-277	90	20	steady	steady	ADJ
admet-277	90	21	state	state	NOUN
admet-277	90	22	at	at	ADP
admet-277	90	23	ph	ph	PROPN
admet-277	90	24	>	>	X
admet-277	90	25	pka	pka	PROPN
admet-277	90	26	for	for	ADP
admet-277	90	27	acids	acid	NOUN
admet-277	90	28	.	.	PUNCT
admet-277	91	1	the	the	DET
admet-277	91	2	pka	pka	PROPN
admet-277	91	3	of	of	ADP
admet-277	91	4	diclofenac	diclofenac	NOUN
admet-277	91	5	has	have	AUX
admet-277	91	6	been	be	AUX
admet-277	91	7	reported	report	VERB
admet-277	91	8	to	to	PART
admet-277	91	9	be	be	AUX
admet-277	91	10	ca	ca	NOUN
admet-277	91	11	.	.	PUNCT
admet-277	91	12	4.0	4.0	NUM
admet-277	91	13	in	in	ADP
admet-277	91	14	most	most	ADJ
admet-277	91	15	cases	case	NOUN
admet-277	91	16	in	in	ADP
admet-277	91	17	the	the	DET
admet-277	91	18	literature	literature	NOUN
admet-277	91	19	.	.	PUNCT
admet-277	92	1	however	however	ADV
admet-277	92	2	,	,	PUNCT
admet-277	92	3	pka	pka	PROPN
admet-277	92	4	of	of	ADP
admet-277	92	5	5.7	5.7	NUM
admet-277	92	6	was	be	AUX
admet-277	92	7	obtained	obtain	VERB
admet-277	92	8	from	from	ADP
admet-277	92	9	the	the	DET
admet-277	92	10	ph	ph	VERB
admet-277	92	11	-	-	PUNCT
admet-277	92	12	solubility	solubility	NOUN
admet-277	92	13	profile	profile	NOUN
admet-277	92	14	[	[	X
admet-277	92	15	15	15	NUM
admet-277	92	16	]	]	PUNCT
admet-277	92	17	.	.	PUNCT
admet-277	93	1	the	the	DET
admet-277	93	2	papp	papp	NOUN
admet-277	93	3	value	value	NOUN
admet-277	93	4	at	at	ADP
admet-277	93	5	a	a	DET
admet-277	93	6	ph	ph	NOUN
admet-277	93	7	where	where	SCONJ
admet-277	93	8	a	a	DET
admet-277	93	9	drug	drug	NOUN
admet-277	93	10	molecule	molecule	NOUN
admet-277	93	11	is	be	AUX
admet-277	93	12	undissociable	undissociable	ADJ
admet-277	93	13	(	(	PUNCT
admet-277	93	14	intrinsic	intrinsic	ADJ
admet-277	93	15	water	water	NOUN
admet-277	93	16	permeability	permeability	NOUN
admet-277	93	17	,	,	PUNCT
admet-277	93	18	pw	pw	PROPN
admet-277	93	19	,	,	PUNCT
admet-277	93	20	int	int	NOUN
admet-277	93	21	)	)	PUNCT
admet-277	93	22	also	also	ADV
admet-277	93	23	correlated	correlate	VERB
admet-277	93	24	with	with	ADP
admet-277	93	25	log	log	NOUN
admet-277	93	26	p.	p.	NOUN
admet-277	93	27	however	however	ADV
admet-277	93	28	,	,	PUNCT
admet-277	93	29	pw	pw	PROPN
admet-277	93	30	,	,	PUNCT
admet-277	93	31	int	int	NOUN
admet-277	93	32	deviated	deviate	VERB
admet-277	93	33	from	from	ADP
admet-277	93	34	the	the	DET
admet-277	93	35	log	log	NOUN
admet-277	93	36	papp	papp	NOUN
admet-277	93	37	–	–	PUNCT
admet-277	93	38	log	log	VERB
admet-277	93	39	p	p	NOUN
admet-277	93	40	line	line	NOUN
admet-277	93	41	for	for	ADP
admet-277	93	42	the	the	DET
admet-277	93	43	undissociable	undissociable	ADJ
admet-277	93	44	drugs	drug	NOUN
admet-277	93	45	about	about	ADP
admet-277	93	46	0.3	0.3	NUM
admet-277	93	47	log	log	NOUN
admet-277	93	48	unit	unit	NOUN
admet-277	93	49	.	.	PUNCT
admet-277	94	1	the	the	DET
admet-277	94	2	difference	difference	NOUN
admet-277	94	3	of	of	ADP
admet-277	94	4	the	the	DET
admet-277	94	5	water	water	NOUN
admet-277	94	6	membrane	membrane	NOUN
admet-277	94	7	(	(	PUNCT
admet-277	94	8	pure	pure	ADJ
admet-277	94	9	water	water	NOUN
admet-277	94	10	vs.	vs.	ADP
admet-277	94	11	a	a	DET
admet-277	94	12	buffer	buffer	NOUN
admet-277	94	13	)	)	PUNCT
admet-277	94	14	could	could	AUX
admet-277	94	15	be	be	AUX
admet-277	94	16	a	a	DET
admet-277	94	17	reason	reason	NOUN
admet-277	94	18	for	for	ADP
admet-277	94	19	the	the	DET
admet-277	94	20	discrepancy	discrepancy	NOUN
admet-277	94	21	.	.	PUNCT
admet-277	95	1	the	the	DET
admet-277	95	2	present	present	ADJ
admet-277	95	3	rp	rp	NOUN
admet-277	95	4	-	-	PUNCT
admet-277	95	5	pampa	pampa	NOUN
admet-277	95	6	method	method	NOUN
admet-277	95	7	admet	admet	PROPN
admet-277	95	8	&	&	CCONJ
admet-277	95	9	dmpk	dmpk	PROPN
admet-277	95	10	4(1	4(1	NOUN
admet-277	95	11	)	)	PUNCT
admet-277	95	12	(	(	PUNCT
admet-277	95	13	2016	2016	NUM
admet-277	95	14	)	)	PUNCT
admet-277	95	15	54	54	NUM
admet-277	95	16	-	-	SYM
admet-277	95	17	59	59	NUM
admet-277	95	18	reversed	reverse	VERB
admet-277	95	19	phase	phase	NOUN
admet-277	95	20	pampa	pampa	NOUN
admet-277	95	21	doi	doi	PROPN
admet-277	95	22	:	:	PUNCT
admet-277	95	23	10.5599	10.5599	NUM
admet-277	95	24	/	/	SYM
admet-277	95	25	admet.4.1.277	admet.4.1.277	PROPN
admet-277	95	26	59	59	NUM
admet-277	95	27	needs	need	VERB
admet-277	95	28	to	to	PART
admet-277	95	29	be	be	AUX
admet-277	95	30	improved	improve	VERB
admet-277	95	31	for	for	ADP
admet-277	95	32	pka	pka	PROPN
admet-277	95	33	measurement	measurement	NOUN
admet-277	95	34	in	in	ADP
admet-277	95	35	the	the	DET
admet-277	95	36	future	future	NOUN
admet-277	95	37	.	.	PUNCT
admet-277	96	1	in	in	ADP
admet-277	96	2	conclusion	conclusion	NOUN
admet-277	96	3	,	,	PUNCT
admet-277	96	4	in	in	ADP
admet-277	96	5	the	the	DET
admet-277	96	6	present	present	ADJ
admet-277	96	7	study	study	NOUN
admet-277	96	8	,	,	PUNCT
admet-277	96	9	rp	rp	NOUN
admet-277	96	10	-	-	NOUN
admet-277	96	11	pampa	pampa	NOUN
admet-277	96	12	for	for	ADP
admet-277	96	13	log	log	NOUN
admet-277	96	14	p	p	PROPN
admet-277	96	15	measurement	measurement	NOUN
admet-277	96	16	was	be	AUX
admet-277	96	17	constructed	construct	VERB
admet-277	96	18	for	for	ADP
admet-277	96	19	the	the	DET
admet-277	96	20	first	first	ADJ
admet-277	96	21	time	time	NOUN
admet-277	96	22	.	.	PUNCT
admet-277	97	1	1.0	1.0	NUM
admet-277	97	2	%	%	NOUN
admet-277	97	3	agarose	agarose	NOUN
admet-277	97	4	can	can	AUX
admet-277	97	5	be	be	AUX
admet-277	97	6	used	use	VERB
admet-277	97	7	to	to	PART
admet-277	97	8	stabilize	stabilize	VERB
admet-277	97	9	the	the	DET
admet-277	97	10	water	water	NOUN
admet-277	97	11	membrane	membrane	NOUN
admet-277	97	12	.	.	PUNCT
admet-277	98	1	rp	rp	NOUN
admet-277	98	2	-	-	PUNCT
admet-277	98	3	pampa	pampa	PROPN
admet-277	98	4	was	be	AUX
admet-277	98	5	applied	apply	VERB
admet-277	98	6	to	to	PART
admet-277	98	7	log	log	VERB
admet-277	98	8	p	p	NOUN
admet-277	98	9	and	and	CCONJ
admet-277	98	10	pka	pka	PROPN
admet-277	98	11	measurements	measurement	NOUN
admet-277	98	12	.	.	PUNCT
admet-277	99	1	as	as	SCONJ
admet-277	99	2	pampa	pampa	PROPN
admet-277	99	3	is	be	AUX
admet-277	99	4	compatible	compatible	ADJ
admet-277	99	5	with	with	ADP
admet-277	99	6	the	the	DET
admet-277	99	7	current	current	ADJ
admet-277	99	8	hts	hts	PROPN
admet-277	99	9	instrument	instrument	NOUN
admet-277	99	10	,	,	PUNCT
admet-277	99	11	rp	rp	NOUN
admet-277	99	12	-	-	PUNCT
admet-277	99	13	pampa	pampa	NOUN
admet-277	99	14	will	will	AUX
admet-277	99	15	be	be	AUX
admet-277	99	16	a	a	DET
admet-277	99	17	useful	useful	ADJ
admet-277	99	18	tool	tool	NOUN
admet-277	99	19	in	in	ADP
admet-277	99	20	drug	drug	NOUN
admet-277	99	21	discovery	discovery	NOUN
admet-277	99	22	.	.	PUNCT
admet-277	100	1	references	reference	NOUN
admet-277	100	2	[	[	X
admet-277	100	3	1	1	NUM
admet-277	100	4	]	]	PUNCT
admet-277	100	5	a.	a.	NOUN
admet-277	100	6	avdeef	avdeef	PROPN
admet-277	100	7	.	.	PUNCT
admet-277	101	1	absorption	absorption	NOUN
admet-277	101	2	and	and	CCONJ
admet-277	101	3	drug	drug	NOUN
admet-277	101	4	development	development	NOUN
admet-277	101	5	.	.	PUNCT
admet-277	102	1	hoboken	hoboken	PROPN
admet-277	102	2	:	:	PUNCT
admet-277	102	3	wiley	wiley	PROPN
admet-277	102	4	-	-	PUNCT
admet-277	102	5	interscience	interscience	PROPN
admet-277	102	6	,	,	PUNCT
admet-277	102	7	nj	nj	PROPN
admet-277	102	8	;	;	PUNCT
admet-277	102	9	2003	2003	NUM
admet-277	102	10	.	.	PUNCT
admet-277	103	1	[	[	X
admet-277	103	2	2	2	NUM
admet-277	103	3	]	]	PUNCT
admet-277	103	4	m.	m.	NOUN
admet-277	103	5	kansy	kansy	PROPN
admet-277	103	6	,	,	PUNCT
admet-277	103	7	f.	f.	PROPN
admet-277	103	8	senner	senner	PROPN
admet-277	103	9	,	,	PUNCT
admet-277	103	10	k.	k.	PROPN
admet-277	103	11	gubernator	gubernator	PROPN
admet-277	103	12	.	.	PUNCT
admet-277	104	1	j.	j.	PROPN
admet-277	104	2	med	med	PROPN
admet-277	104	3	.	.	PROPN
admet-277	104	4	chem	chem	PROPN
admet-277	104	5	.	.	PUNCT
admet-277	105	1	41	41	NUM
admet-277	105	2	(	(	PUNCT
admet-277	105	3	1998	1998	NUM
admet-277	105	4	)	)	PUNCT
admet-277	105	5	1007	1007	NUM
admet-277	105	6	-	-	SYM
admet-277	105	7	1010	1010	NUM
admet-277	105	8	.	.	PUNCT
admet-277	106	1	[	[	X
admet-277	106	2	3	3	NUM
admet-277	106	3	]	]	PUNCT
admet-277	106	4	a.	a.	NOUN
admet-277	106	5	avdeef	avdeef	PROPN
admet-277	106	6	,	,	PUNCT
admet-277	106	7	s.	s.	PROPN
admet-277	106	8	bendels	bendels	PROPN
admet-277	106	9	,	,	PUNCT
admet-277	106	10	l.	l.	PROPN
admet-277	106	11	di	di	PROPN
admet-277	106	12	,	,	PUNCT
admet-277	106	13	b.	b.	PROPN
admet-277	106	14	faller	faller	PROPN
admet-277	106	15	,	,	PUNCT
admet-277	106	16	m.	m.	PROPN
admet-277	106	17	kansy	kansy	PROPN
admet-277	106	18	,	,	PUNCT
admet-277	106	19	k.	k.	PROPN
admet-277	106	20	sugano	sugano	PROPN
admet-277	106	21	,	,	PUNCT
admet-277	106	22	y.	y.	PROPN
admet-277	106	23	yamauchi	yamauchi	PROPN
admet-277	106	24	.	.	PUNCT
admet-277	107	1	j.	j.	PROPN
admet-277	107	2	pharm	pharm	PROPN
admet-277	107	3	.	.	PUNCT
admet-277	108	1	sci	sci	PROPN
admet-277	108	2	.	.	PROPN
admet-277	109	1	96	96	NUM
admet-277	109	2	(	(	PUNCT
admet-277	109	3	2007	2007	NUM
admet-277	109	4	)	)	PUNCT
admet-277	109	5	2893	2893	NUM
admet-277	109	6	-	-	SYM
admet-277	109	7	2909	2909	NUM
admet-277	109	8	.	.	PUNCT
admet-277	110	1	[	[	X
admet-277	110	2	4	4	NUM
admet-277	110	3	]	]	X
admet-277	110	4	b.	b.	PROPN
admet-277	110	5	faller	faller	PROPN
admet-277	110	6	,	,	PUNCT
admet-277	110	7	h.p	h.p	PROPN
admet-277	110	8	.	.	PROPN
admet-277	110	9	grimm	grimm	PROPN
admet-277	110	10	,	,	PUNCT
admet-277	110	11	f.	f.	PROPN
admet-277	110	12	loeuillet	loeuillet	PROPN
admet-277	110	13	-	-	PUNCT
admet-277	110	14	ritzler	ritzler	NOUN
admet-277	110	15	,	,	PUNCT
admet-277	110	16	s.	s.	PROPN
admet-277	110	17	arnold	arnold	PROPN
admet-277	110	18	,	,	PUNCT
admet-277	110	19	x.	x.	PROPN
admet-277	110	20	briand	briand	PROPN
admet-277	110	21	.	.	PUNCT
admet-277	111	1	j.	j.	PROPN
admet-277	111	2	med	med	PROPN
admet-277	111	3	.	.	PROPN
admet-277	111	4	chem	chem	PROPN
admet-277	111	5	.	.	PUNCT
admet-277	112	1	48	48	NUM
admet-277	112	2	(	(	PUNCT
admet-277	112	3	2005	2005	NUM
admet-277	112	4	)	)	PUNCT
admet-277	112	5	2571	2571	NUM
admet-277	112	6	-	-	SYM
admet-277	112	7	2576	2576	NUM
admet-277	112	8	.	.	PUNCT
admet-277	113	1	[	[	X
admet-277	113	2	5	5	NUM
admet-277	113	3	]	]	PUNCT
admet-277	113	4	m.	m.	NOUN
admet-277	113	5	kansy	kansy	PROPN
admet-277	113	6	,	,	PUNCT
admet-277	113	7	h.	h.	PROPN
admet-277	113	8	fischer	fischer	PROPN
admet-277	113	9	,	,	PUNCT
admet-277	113	10	k.	k.	PROPN
admet-277	113	11	kratzat	kratzat	PROPN
admet-277	113	12	,	,	PUNCT
admet-277	113	13	f.	f.	PROPN
admet-277	113	14	senner	senner	PROPN
admet-277	113	15	,	,	PUNCT
admet-277	113	16	b.	b.	PROPN
admet-277	113	17	wagner	wagner	PROPN
admet-277	113	18	,	,	PUNCT
admet-277	113	19	i.	i.	PROPN
admet-277	113	20	parrilla	parrilla	PROPN
admet-277	113	21	.	.	PUNCT
admet-277	114	1	high	high	ADJ
admet-277	114	2	-	-	PUNCT
admet-277	114	3	throughput	throughput	NOUN
admet-277	114	4	artifical	artifical	ADJ
admet-277	114	5	membrane	membrane	NOUN
admet-277	114	6	permeability	permeability	NOUN
admet-277	114	7	studies	study	NOUN
admet-277	114	8	in	in	ADP
admet-277	114	9	early	early	ADJ
admet-277	114	10	lead	lead	NOUN
admet-277	114	11	discovery	discovery	NOUN
admet-277	114	12	and	and	CCONJ
admet-277	114	13	development	development	NOUN
admet-277	114	14	.	.	PUNCT
admet-277	115	1	in	in	ADP
admet-277	115	2	:	:	PUNCT
admet-277	115	3	testa	testa	PROPN
admet-277	115	4	b	b	PROPN
admet-277	115	5	,	,	PUNCT
admet-277	115	6	van	van	PROPN
admet-277	115	7	de	de	PROPN
admet-277	115	8	waterbeemd	waterbeemd	PROPN
admet-277	115	9	h	h	PROPN
admet-277	115	10	,	,	PUNCT
admet-277	115	11	folkers	folker	NOUN
admet-277	115	12	g	g	NOUN
admet-277	115	13	,	,	PUNCT
admet-277	115	14	guy	guy	NOUN
admet-277	115	15	r	r	NOUN
admet-277	115	16	,	,	PUNCT
admet-277	115	17	editors	editor	NOUN
admet-277	115	18	.	.	PUNCT
admet-277	116	1	pharmacokinetic	pharmacokinetic	ADJ
admet-277	116	2	optimization	optimization	NOUN
admet-277	116	3	in	in	ADP
admet-277	116	4	drug	drug	NOUN
admet-277	116	5	research	research	NOUN
admet-277	116	6	.	.	PUNCT
admet-277	117	1	zürich	zürich	NOUN
admet-277	117	2	:	:	PUNCT
admet-277	117	3	wiley	wiley	PROPN
admet-277	117	4	-	-	PUNCT
admet-277	117	5	vch	vch	PROPN
admet-277	117	6	;	;	PUNCT
admet-277	117	7	2001	2001	NUM
admet-277	117	8	.	.	PUNCT
admet-277	118	1	p.	p.	NOUN
admet-277	118	2	447	447	NUM
admet-277	118	3	-	-	SYM
admet-277	118	4	464	464	NUM
admet-277	118	5	.	.	PUNCT
admet-277	119	1	[	[	X
admet-277	119	2	6	6	NUM
admet-277	119	3	]	]	PUNCT
admet-277	119	4	k.	k.	PROPN
admet-277	119	5	sugano	sugano	PROPN
admet-277	119	6	,	,	PUNCT
admet-277	119	7	h.	h.	PROPN
admet-277	119	8	hamada	hamada	PROPN
admet-277	119	9	,	,	PUNCT
admet-277	119	10	m.	m.	PROPN
admet-277	119	11	machida	machida	PROPN
admet-277	119	12	,	,	PUNCT
admet-277	119	13	h.	h.	PROPN
admet-277	119	14	ushio	ushio	PROPN
admet-277	119	15	.	.	PUNCT
admet-277	120	1	j.	j.	PROPN
admet-277	120	2	biomol	biomol	PROPN
admet-277	120	3	.	.	PUNCT
admet-277	121	1	screen	screen	NOUN
admet-277	121	2	.	.	PUNCT
admet-277	122	1	6	6	NUM
admet-277	122	2	(	(	PUNCT
admet-277	122	3	2001	2001	NUM
admet-277	122	4	)	)	PUNCT
admet-277	122	5	189	189	NUM
admet-277	122	6	-	-	SYM
admet-277	122	7	196	196	NUM
admet-277	122	8	.	.	PUNCT
admet-277	123	1	[	[	X
admet-277	123	2	7	7	X
admet-277	123	3	]	]	X
admet-277	123	4	k.j	k.j	PROPN
admet-277	123	5	.	.	PROPN
admet-277	123	6	box	box	PROPN
admet-277	123	7	,	,	PUNCT
admet-277	123	8	j.e	j.e	PROPN
admet-277	123	9	.	.	PROPN
admet-277	123	10	comer	comer	PROPN
admet-277	123	11	.	.	PUNCT
admet-277	124	1	curr	curr	PROPN
admet-277	124	2	.	.	PUNCT
admet-277	124	3	drug	drug	PROPN
admet-277	124	4	metab	metab	NOUN
admet-277	124	5	.	.	PUNCT
admet-277	125	1	9	9	NUM
admet-277	125	2	(	(	PUNCT
admet-277	125	3	2008	2008	NUM
admet-277	125	4	)	)	PUNCT
admet-277	125	5	869	869	NUM
admet-277	125	6	-	-	SYM
admet-277	125	7	878	878	NUM
admet-277	125	8	.	.	PUNCT
admet-277	126	1	[	[	X
admet-277	126	2	8	8	NUM
admet-277	126	3	]	]	X
admet-277	126	4	drugbank	drugbank	NOUN
admet-277	126	5	.	.	PUNCT
admet-277	127	1	http://www.drugbank.ca/.	http://www.drugbank.ca/.	PUNCT
admet-277	128	1	[	[	X
admet-277	128	2	9	9	NUM
admet-277	128	3	]	]	PUNCT
admet-277	128	4	k.	k.	PROPN
admet-277	128	5	sugano	sugano	PROPN
admet-277	128	6	.	.	PUNCT
admet-277	129	1	biopharmaceutics	biopharmaceutics	NOUN
admet-277	129	2	modeling	modeling	NOUN
admet-277	129	3	and	and	CCONJ
admet-277	129	4	simulations	simulation	NOUN
admet-277	129	5	:	:	PUNCT
admet-277	130	1	theory	theory	NOUN
admet-277	130	2	,	,	PUNCT
admet-277	130	3	practice	practice	NOUN
admet-277	130	4	,	,	PUNCT
admet-277	130	5	methods	method	NOUN
admet-277	130	6	,	,	PUNCT
admet-277	130	7	and	and	CCONJ
admet-277	130	8	applications	application	NOUN
admet-277	130	9	.	.	PUNCT
admet-277	131	1	new	new	PROPN
admet-277	131	2	jersey	jersey	PROPN
admet-277	131	3	:	:	PUNCT
admet-277	131	4	john	john	PROPN
admet-277	131	5	wiley	wiley	PROPN
admet-277	131	6	&	&	CCONJ
admet-277	131	7	sons	sons	PROPN
admet-277	131	8	,	,	PUNCT
admet-277	131	9	inc	inc	PROPN
admet-277	131	10	.	.	PROPN
admet-277	131	11	;	;	PUNCT
admet-277	131	12	2012	2012	NUM
admet-277	131	13	.	.	PUNCT
admet-277	132	1	[	[	X
admet-277	132	2	10	10	NUM
admet-277	132	3	]	]	X
admet-277	132	4	n.	n.	NOUN
admet-277	132	5	fatin	fatin	NOUN
admet-277	132	6	-	-	PUNCT
admet-277	132	7	rouge	rouge	NOUN
admet-277	132	8	,	,	PUNCT
admet-277	132	9	k.	k.	PROPN
admet-277	132	10	starchev	starchev	PROPN
admet-277	132	11	,	,	PUNCT
admet-277	132	12	j.	j.	PROPN
admet-277	132	13	buffle	buffle	PROPN
admet-277	132	14	.	.	PUNCT
admet-277	133	1	biophys	biophy	NOUN
admet-277	133	2	.	.	PUNCT
admet-277	134	1	j.	j.	PROPN
admet-277	134	2	86	86	PROPN
admet-277	134	3	(	(	PUNCT
admet-277	134	4	2004	2004	NUM
admet-277	134	5	)	)	PUNCT
admet-277	134	6	2710	2710	NUM
admet-277	134	7	-	-	SYM
admet-277	134	8	2719	2719	NUM
admet-277	134	9	.	.	PUNCT
admet-277	135	1	[	[	X
admet-277	135	2	11	11	NUM
admet-277	135	3	]	]	PUNCT
admet-277	135	4	t.	t.	PROPN
admet-277	135	5	xiang	xiang	PROPN
admet-277	135	6	,	,	PUNCT
admet-277	135	7	y.	y.	PROPN
admet-277	135	8	xu	xu	PROPN
admet-277	135	9	,	,	PUNCT
admet-277	135	10	b.	b.	PROPN
admet-277	135	11	d.	d.	PROPN
admet-277	135	12	anderson	anderson	PROPN
admet-277	135	13	.	.	PUNCT
admet-277	136	1	j.	j.	PROPN
admet-277	136	2	membr	membr	PROPN
admet-277	136	3	.	.	PUNCT
admet-277	137	1	biol	biol	PROPN
admet-277	137	2	.	.	PUNCT
admet-277	138	1	165	165	NUM
admet-277	138	2	(	(	PUNCT
admet-277	138	3	1998	1998	NUM
admet-277	138	4	)	)	PUNCT
admet-277	138	5	77	77	NUM
admet-277	138	6	-	-	SYM
admet-277	138	7	90	90	NUM
admet-277	138	8	.	.	PUNCT
admet-277	139	1	[	[	X
admet-277	139	2	12	12	NUM
admet-277	139	3	]	]	X
admet-277	139	4	j.-h	j.-h	NOUN
admet-277	139	5	.	.	PUNCT
admet-277	140	1	kwon	kwon	PROPN
admet-277	140	2	,	,	PUNCT
admet-277	140	3	b.i	b.i	PROPN
admet-277	140	4	.	.	PROPN
admet-277	140	5	escher	escher	PROPN
admet-277	140	6	.	.	PUNCT
admet-277	141	1	environ	environ	PROPN
admet-277	141	2	.	.	PUNCT
admet-277	142	1	sci	sci	PROPN
admet-277	142	2	.	.	PROPN
admet-277	142	3	technol	technol	PROPN
admet-277	142	4	.	.	PUNCT
admet-277	143	1	42	42	NUM
admet-277	143	2	(	(	PUNCT
admet-277	143	3	2008	2008	NUM
admet-277	143	4	)	)	PUNCT
admet-277	143	5	1787	1787	NUM
admet-277	143	6	-	-	SYM
admet-277	143	7	1793	1793	NUM
admet-277	143	8	.	.	PUNCT
admet-277	144	1	[	[	X
admet-277	144	2	13	13	NUM
admet-277	144	3	]	]	X
admet-277	144	4	h.	h.	PROPN
admet-277	144	5	krebs	krebs	PROPN
admet-277	144	6	,	,	PUNCT
admet-277	144	7	j.	j.	PROPN
admet-277	144	8	speakman	speakman	PROPN
admet-277	144	9	.	.	PUNCT
admet-277	145	1	j.	j.	PROPN
admet-277	145	2	chem	chem	PROPN
admet-277	145	3	.	.	PUNCT
admet-277	146	1	soc	soc	PROPN
admet-277	146	2	.	.	PUNCT
admet-277	147	1	(	(	PUNCT
admet-277	147	2	1945	1945	NUM
admet-277	147	3	)	)	PUNCT
admet-277	147	4	593	593	NUM
admet-277	147	5	-	-	SYM
admet-277	147	6	595	595	NUM
admet-277	147	7	.	.	PUNCT
admet-277	148	1	[	[	X
admet-277	148	2	14	14	NUM
admet-277	148	3	]	]	X
admet-277	148	4	i.	i.	PROPN
admet-277	148	5	zimmermann	zimmermann	PROPN
admet-277	148	6	.	.	PUNCT
admet-277	149	1	int	int	PROPN
admet-277	149	2	.	.	PUNCT
admet-277	150	1	j.	j.	PROPN
admet-277	150	2	pharm	pharm	PROPN
admet-277	150	3	.	.	PUNCT
admet-277	151	1	13	13	NUM
admet-277	151	2	(	(	PUNCT
admet-277	151	3	1982	1982	NUM
admet-277	151	4	)	)	PUNCT
admet-277	151	5	57	57	NUM
admet-277	151	6	-	-	SYM
admet-277	151	7	65	65	NUM
admet-277	151	8	.	.	PUNCT
admet-277	152	1	[	[	X
admet-277	152	2	15	15	NUM
admet-277	152	3	]	]	X
admet-277	152	4	a.	a.	NOUN
admet-277	152	5	pobudkowska	pobudkowska	NOUN
admet-277	152	6	,	,	PUNCT
admet-277	152	7	u.	u.	PROPN
admet-277	152	8	domańska	domańska	PROPN
admet-277	152	9	.	.	PUNCT
admet-277	153	1	chem	chem	PROPN
admet-277	153	2	.	.	PUNCT
admet-277	154	1	ind	ind	PROPN
admet-277	154	2	.	.	PUNCT
admet-277	155	1	chem	chem	PROPN
admet-277	155	2	.	.	PUNCT
admet-277	156	1	eng	eng	PROPN
admet-277	156	2	.	.	PUNCT
admet-277	156	3	q.	q.	PROPN
admet-277	156	4	20	20	NUM
admet-277	156	5	(	(	PUNCT
admet-277	156	6	2014	2014	NUM
admet-277	156	7	)	)	PUNCT
admet-277	156	8	115	115	NUM
admet-277	156	9	-	-	SYM
admet-277	156	10	126	126	NUM
admet-277	156	11	.	.	PUNCT
admet-277	157	1	©	©	PROPN
admet-277	157	2	2016	2016	NUM
admet-277	157	3	by	by	ADP
admet-277	157	4	the	the	DET
admet-277	157	5	authors	author	NOUN
admet-277	157	6	;	;	PUNCT
admet-277	157	7	licensee	licensee	PROPN
admet-277	157	8	iapc	iapc	PROPN
admet-277	157	9	,	,	PUNCT
admet-277	157	10	zagreb	zagreb	PROPN
admet-277	157	11	,	,	PUNCT
admet-277	157	12	croatia	croatia	PROPN
admet-277	157	13	.	.	PUNCT
admet-277	158	1	this	this	DET
admet-277	158	2	article	article	NOUN
admet-277	158	3	is	be	AUX
admet-277	158	4	an	an	DET
admet-277	158	5	open	open	ADJ
admet-277	158	6	-	-	PUNCT
admet-277	158	7	access	access	NOUN
admet-277	158	8	article	article	NOUN
admet-277	158	9	distributed	distribute	VERB
admet-277	158	10	under	under	ADP
admet-277	158	11	the	the	DET
admet-277	158	12	terms	term	NOUN
admet-277	158	13	and	and	CCONJ
admet-277	158	14	conditions	condition	NOUN
admet-277	158	15	of	of	ADP
admet-277	158	16	the	the	DET
admet-277	158	17	creative	creative	ADJ
admet-277	158	18	commons	common	NOUN
admet-277	158	19	attribution	attribution	NOUN
admet-277	158	20	license	license	NOUN
admet-277	158	21	(	(	PUNCT
admet-277	158	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-277	158	23	)	)	PUNCT
admet-277	158	24	http://www.drugbank.ca/	http://www.drugbank.ca/	NUM
admet-277	159	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN