id	sid	tid	token	lemma	pos
admet-2774	1	1	fabrication	fabrication	NOUN
admet-2774	1	2	and	and	CCONJ
admet-2774	1	3	optimization	optimization	NOUN
admet-2774	1	4	of	of	ADP
admet-2774	1	5	freeze	freeze	NOUN
admet-2774	1	6	-	-	PUNCT
admet-2774	1	7	dried	dry	VERB
admet-2774	1	8	isoniazid	isoniazid	NOUN
admet-2774	1	9	-	-	PUNCT
admet-2774	1	10	loaded	load	VERB
admet-2774	1	11	poly	poly	ADJ
admet-2774	1	12	-	-	PUNCT
admet-2774	1	13	ε	ε	NOUN
admet-2774	1	14	-	-	PUNCT
admet-2774	1	15	caprolactone	caprolactone	ADJ
admet-2774	1	16	nanoparticles	nanoparticle	NOUN
admet-2774	1	17	doi	doi	NOUN
admet-2774	1	18	:	:	PUNCT
admet-2774	1	19	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	1	20	1	1	NUM
admet-2774	1	21	admet	admet	X
admet-2774	1	22	&	&	CCONJ
admet-2774	1	23	dmpk	dmpk	PROPN
admet-2774	1	24	13(4	13(4	NUM
admet-2774	1	25	)	)	PUNCT
admet-2774	1	26	(	(	PUNCT
admet-2774	1	27	2025	2025	NUM
admet-2774	1	28	)	)	PUNCT
admet-2774	1	29	2774	2774	NUM
admet-2774	1	30	;	;	PUNCT
admet-2774	1	31	doi	doi	NOUN
admet-2774	1	32	:	:	PUNCT
admet-2774	1	33	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	PUNCT
admet-2774	1	34	open	open	ADJ
admet-2774	1	35	access	access	NOUN
admet-2774	1	36	:	:	PUNCT
admet-2774	1	37	issn	issn	PROPN
admet-2774	1	38	:	:	PUNCT
admet-2774	1	39	1848	1848	NUM
admet-2774	1	40	-	-	SYM
admet-2774	1	41	7718	7718	NUM
admet-2774	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2774	1	43	original	original	ADJ
admet-2774	1	44	scientific	scientific	ADJ
admet-2774	1	45	paper	paper	NOUN
admet-2774	1	46	fabrication	fabrication	NOUN
admet-2774	1	47	and	and	CCONJ
admet-2774	1	48	optimization	optimization	NOUN
admet-2774	1	49	of	of	ADP
admet-2774	1	50	freeze	freeze	NOUN
admet-2774	1	51	-	-	PUNCT
admet-2774	1	52	dried	dry	VERB
admet-2774	1	53	isoniazid	isoniazid	NOUN
admet-2774	1	54	-	-	PUNCT
admet-2774	1	55	loaded	load	VERB
admet-2774	1	56	poly	poly	ADJ
admet-2774	1	57	-	-	PUNCT
admet-2774	1	58	ε	ε	NOUN
admet-2774	1	59	-	-	PUNCT
admet-2774	1	60	caprolactone	caprolactone	ADJ
admet-2774	1	61	nanoparticles	nanoparticle	NOUN
admet-2774	1	62	eknath	eknath	VERB
admet-2774	1	63	kole1	kole1	ADJ
admet-2774	1	64	,	,	PUNCT
admet-2774	1	65	yuvraj	yuvraj	PROPN
admet-2774	1	66	pawara2	pawara2	PROPN
admet-2774	1	67	,	,	PUNCT
admet-2774	1	68	atul	atul	PROPN
admet-2774	1	69	chaudhari1	chaudhari1	PROPN
admet-2774	1	70	,	,	PUNCT
admet-2774	1	71	aniruddha	aniruddha	NOUN
admet-2774	1	72	chatterjee3	chatterjee3	NOUN
admet-2774	1	73	and	and	CCONJ
admet-2774	1	74	jitendra	jitendra	PROPN
admet-2774	1	75	naik1	naik1	PROPN
admet-2774	1	76	,	,	PUNCT
admet-2774	1	77	*	*	PROPN
admet-2774	1	78	1department	1department	NUM
admet-2774	1	79	of	of	ADP
admet-2774	1	80	pharmaceutical	pharmaceutical	ADJ
admet-2774	1	81	technology	technology	NOUN
admet-2774	1	82	,	,	PUNCT
admet-2774	1	83	university	university	NOUN
admet-2774	1	84	institute	institute	NOUN
admet-2774	1	85	of	of	ADP
admet-2774	1	86	chemical	chemical	PROPN
admet-2774	1	87	technology	technology	PROPN
admet-2774	1	88	,	,	PUNCT
admet-2774	1	89	kbc	kbc	PROPN
admet-2774	1	90	north	north	PROPN
admet-2774	1	91	maharashtra	maharashtra	PROPN
admet-2774	1	92	university	university	PROPN
admet-2774	1	93	,	,	PUNCT
admet-2774	1	94	jalgaon	jalgaon	PROPN
admet-2774	1	95	ms	ms	PROPN
admet-2774	1	96	425001	425001	PROPN
admet-2774	1	97	,	,	PUNCT
admet-2774	1	98	india	india	PROPN
admet-2774	1	99	2r	2r	NUM
admet-2774	1	100	.	.	PUNCT
admet-2774	2	1	c.	c.	PROPN
admet-2774	2	2	patel	patel	PROPN
admet-2774	2	3	institute	institute	PROPN
admet-2774	2	4	of	of	ADP
admet-2774	2	5	pharmaceutical	pharmaceutical	NOUN
admet-2774	2	6	education	education	NOUN
admet-2774	2	7	and	and	CCONJ
admet-2774	2	8	research	research	NOUN
admet-2774	2	9	,	,	PUNCT
admet-2774	2	10	shirpur	shirpur	NOUN
admet-2774	2	11	,	,	PUNCT
admet-2774	2	12	ms	ms	PROPN
admet-2774	2	13	425405	425405	NUM
admet-2774	2	14	,	,	PUNCT
admet-2774	2	15	india	india	PROPN
admet-2774	2	16	3plastics	3plastics	NUM
admet-2774	2	17	engineering	engineering	NOUN
admet-2774	2	18	department	department	NOUN
admet-2774	2	19	,	,	PUNCT
admet-2774	2	20	plastindia	plastindia	PROPN
admet-2774	2	21	international	international	PROPN
admet-2774	2	22	university	university	PROPN
admet-2774	2	23	,	,	PUNCT
admet-2774	2	24	vapi	vapi	NOUN
admet-2774	2	25	,	,	PUNCT
admet-2774	2	26	gujarat	gujarat	PROPN
admet-2774	2	27	,	,	PUNCT
admet-2774	2	28	india	india	PROPN
admet-2774	2	29	corresponding	corresponding	PROPN
admet-2774	2	30	author	author	NOUN
admet-2774	2	31	:	:	PUNCT
admet-2774	2	32	e	e	NOUN
admet-2774	2	33	-	-	NOUN
admet-2774	2	34	mail	mail	NOUN
admet-2774	2	35	:	:	PUNCT
admet-2774	2	36	*	*	PUNCT
admet-2774	2	37	jitunaik@gmail.com	jitunaik@gmail.com	PROPN
admet-2774	2	38	received	receive	VERB
admet-2774	2	39	:	:	PUNCT
admet-2774	2	40	may	may	AUX
admet-2774	2	41	1	1	NUM
admet-2774	2	42	,	,	PUNCT
admet-2774	2	43	2025	2025	NUM
admet-2774	2	44	;	;	PUNCT
admet-2774	2	45	revised	revise	VERB
admet-2774	2	46	:	:	PUNCT
admet-2774	2	47	july	july	PROPN
admet-2774	2	48	5	5	NUM
admet-2774	2	49	,	,	PUNCT
admet-2774	2	50	2025	2025	NUM
admet-2774	2	51	;	;	PUNCT
admet-2774	2	52	published	publish	VERB
admet-2774	2	53	:	:	PUNCT
admet-2774	2	54	july	july	PROPN
admet-2774	2	55	8	8	NUM
admet-2774	2	56	,	,	PUNCT
admet-2774	2	57	2025	2025	NUM
admet-2774	2	58	abstract	abstract	ADJ
admet-2774	2	59	background	background	NOUN
admet-2774	2	60	:	:	PUNCT
admet-2774	2	61	microfluidic	microfluidic	ADJ
admet-2774	2	62	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	2	63	followed	follow	VERB
admet-2774	2	64	by	by	ADP
admet-2774	2	65	freeze	freeze	NOUN
admet-2774	2	66	-	-	PUNCT
admet-2774	2	67	drying	drying	NOUN
admet-2774	2	68	would	would	AUX
admet-2774	2	69	yield	yield	VERB
admet-2774	2	70	uniformly	uniformly	ADV
admet-2774	2	71	sized	sized	ADJ
admet-2774	2	72	,	,	PUNCT
admet-2774	2	73	stable	stable	ADJ
admet-2774	2	74	nanoparticles	nanoparticle	NOUN
admet-2774	2	75	by	by	ADP
admet-2774	2	76	preserving	preserve	VERB
admet-2774	2	77	their	their	PRON
admet-2774	2	78	physicochemical	physicochemical	ADJ
admet-2774	2	79	property	property	NOUN
admet-2774	2	80	without	without	ADP
admet-2774	2	81	compromising	compromise	VERB
admet-2774	2	82	therapeutic	therapeutic	ADJ
admet-2774	2	83	performance	performance	NOUN
admet-2774	2	84	.	.	PUNCT
admet-2774	3	1	the	the	DET
admet-2774	3	2	isoniazid	isoniazid	NOUN
admet-2774	3	3	(	(	PUNCT
admet-2774	3	4	inh)-loaded	inh)-loade	VERB
admet-2774	3	5	poly	poly	ADJ
admet-2774	3	6	-	-	PUNCT
admet-2774	3	7	ε	ε	NOUN
admet-2774	3	8	-	-	PUNCT
admet-2774	3	9	caprolactone	caprolactone	NOUN
admet-2774	3	10	(	(	PUNCT
admet-2774	3	11	pcl	pcl	PROPN
admet-2774	3	12	)	)	PUNCT
admet-2774	3	13	nanoparticles	nanoparticle	NOUN
admet-2774	3	14	could	could	AUX
admet-2774	3	15	be	be	AUX
admet-2774	3	16	developed	develop	VERB
admet-2774	3	17	using	use	VERB
admet-2774	3	18	a	a	DET
admet-2774	3	19	microfluidic	microfluidic	ADJ
admet-2774	3	20	technique	technique	NOUN
admet-2774	3	21	for	for	ADP
admet-2774	3	22	the	the	DET
admet-2774	3	23	management	management	NOUN
admet-2774	3	24	of	of	ADP
admet-2774	3	25	tuberculosis	tuberculosis	NOUN
admet-2774	3	26	.	.	PUNCT
admet-2774	4	1	experimental	experimental	ADJ
admet-2774	4	2	approach	approach	NOUN
admet-2774	4	3	:	:	PUNCT
admet-2774	4	4	the	the	DET
admet-2774	4	5	inh	inh	NOUN
admet-2774	4	6	-	-	PUNCT
admet-2774	4	7	loaded	load	VERB
admet-2774	4	8	nanoparticles	nanoparticle	NOUN
admet-2774	4	9	were	be	AUX
admet-2774	4	10	fabricated	fabricate	VERB
admet-2774	4	11	via	via	ADP
admet-2774	4	12	a	a	DET
admet-2774	4	13	microreactor	microreactor	NOUN
admet-2774	4	14	-	-	PUNCT
admet-2774	4	15	assisted	assist	VERB
admet-2774	4	16	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	4	17	method	method	NOUN
admet-2774	4	18	and	and	CCONJ
admet-2774	4	19	optimization	optimization	NOUN
admet-2774	4	20	using	use	VERB
admet-2774	4	21	a	a	DET
admet-2774	4	22	design	design	NOUN
admet-2774	4	23	of	of	ADP
admet-2774	4	24	experiments	experiment	NOUN
admet-2774	4	25	factorial	factorial	ADJ
admet-2774	4	26	design	design	NOUN
admet-2774	4	27	approach	approach	NOUN
admet-2774	4	28	.	.	PUNCT
admet-2774	5	1	the	the	DET
admet-2774	5	2	resulting	result	VERB
admet-2774	5	3	inh	inh	PROPN
admet-2774	5	4	-	-	PUNCT
admet-2774	5	5	pcl	pcl	PROPN
admet-2774	5	6	nanoformulation	nanoformulation	NOUN
admet-2774	5	7	was	be	AUX
admet-2774	5	8	characterized	characterize	VERB
admet-2774	5	9	for	for	ADP
admet-2774	5	10	particle	particle	NOUN
admet-2774	5	11	size	size	NOUN
admet-2774	5	12	,	,	PUNCT
admet-2774	5	13	polydispersity	polydispersity	NOUN
admet-2774	5	14	index	index	NOUN
admet-2774	5	15	(	(	PUNCT
admet-2774	5	16	pdi	pdi	PROPN
admet-2774	5	17	)	)	PUNCT
admet-2774	5	18	,	,	PUNCT
admet-2774	5	19	zeta	zeta	NOUN
admet-2774	5	20	potential	potential	NOUN
admet-2774	5	21	(	(	PUNCT
admet-2774	5	22	surface	surface	NOUN
admet-2774	5	23	charge	charge	NOUN
admet-2774	5	24	)	)	PUNCT
admet-2774	5	25	,	,	PUNCT
admet-2774	5	26	fourier	fourier	NOUN
admet-2774	5	27	-	-	PUNCT
admet-2774	5	28	transform	transform	VERB
admet-2774	5	29	infrared	infrared	ADJ
admet-2774	5	30	spectroscopy	spectroscopy	NOUN
admet-2774	5	31	,	,	PUNCT
admet-2774	5	32	differential	differential	NOUN
admet-2774	5	33	scanning	scanning	NOUN
admet-2774	5	34	calorimetry	calorimetry	NOUN
admet-2774	5	35	,	,	PUNCT
admet-2774	5	36	x	x	ADJ
admet-2774	5	37	-	-	NOUN
admet-2774	5	38	ray	ray	NOUN
admet-2774	5	39	diffraction	diffraction	NOUN
admet-2774	5	40	analysis	analysis	NOUN
admet-2774	5	41	and	and	CCONJ
admet-2774	5	42	field	field	NOUN
admet-2774	5	43	emission	emission	NOUN
admet-2774	5	44	scanning	scan	VERB
admet-2774	5	45	electron	electron	NOUN
admet-2774	5	46	microscope	microscope	NOUN
admet-2774	5	47	.	.	PUNCT
admet-2774	6	1	key	key	ADJ
admet-2774	6	2	results	result	NOUN
admet-2774	6	3	:	:	PUNCT
admet-2774	6	4	the	the	DET
admet-2774	6	5	optimized	optimize	VERB
admet-2774	6	6	nanoparticles	nanoparticle	NOUN
admet-2774	6	7	exhibited	exhibit	VERB
admet-2774	6	8	an	an	DET
admet-2774	6	9	average	average	ADJ
admet-2774	6	10	particle	particle	NOUN
admet-2774	6	11	size	size	NOUN
admet-2774	6	12	(	(	PUNCT
admet-2774	6	13	248.4	248.4	NUM
admet-2774	6	14	±	±	NUM
admet-2774	6	15	5.372	5.372	NUM
admet-2774	6	16	nm	nm	NOUN
admet-2774	6	17	)	)	PUNCT
admet-2774	6	18	and	and	CCONJ
admet-2774	6	19	high	high	ADJ
admet-2774	6	20	encapsulation	encapsulation	NOUN
admet-2774	6	21	efficiency	efficiency	NOUN
admet-2774	6	22	(	(	PUNCT
admet-2774	6	23	82.26	82.26	NUM
admet-2774	6	24	±	±	NUM
admet-2774	6	25	4.36	4.36	NUM
admet-2774	6	26	%	%	NOUN
admet-2774	6	27	)	)	PUNCT
admet-2774	6	28	.	.	PUNCT
admet-2774	7	1	thermal	thermal	ADJ
admet-2774	7	2	and	and	CCONJ
admet-2774	7	3	spectroscopic	spectroscopic	ADJ
admet-2774	7	4	analyses	analysis	NOUN
admet-2774	7	5	confirmed	confirm	VERB
admet-2774	7	6	the	the	DET
admet-2774	7	7	absence	absence	NOUN
admet-2774	7	8	of	of	ADP
admet-2774	7	9	drug	drug	NOUN
admet-2774	7	10	-	-	PUNCT
admet-2774	7	11	polymer	polymer	NOUN
admet-2774	7	12	interactions	interaction	NOUN
admet-2774	7	13	,	,	PUNCT
admet-2774	7	14	ensuring	ensure	VERB
admet-2774	7	15	formulation	formulation	NOUN
admet-2774	7	16	integrity	integrity	NOUN
admet-2774	7	17	;	;	PUNCT
admet-2774	7	18	stability	stability	NOUN
admet-2774	7	19	studies	study	NOUN
admet-2774	7	20	under	under	ADP
admet-2774	7	21	accelerated	accelerated	ADJ
admet-2774	7	22	conditions	condition	NOUN
admet-2774	7	23	demonstrated	demonstrate	VERB
admet-2774	7	24	negligible	negligible	ADJ
admet-2774	7	25	changes	change	NOUN
admet-2774	7	26	in	in	ADP
admet-2774	7	27	particle	particle	NOUN
admet-2774	7	28	size	size	NOUN
admet-2774	7	29	,	,	PUNCT
admet-2774	7	30	pdi	pdi	NOUN
admet-2774	7	31	,	,	PUNCT
admet-2774	7	32	and	and	CCONJ
admet-2774	7	33	zeta	zeta	PROPN
admet-2774	7	34	potential	potential	NOUN
admet-2774	7	35	over	over	ADP
admet-2774	7	36	the	the	DET
admet-2774	7	37	period	period	NOUN
admet-2774	7	38	of	of	ADP
admet-2774	7	39	6	6	NUM
admet-2774	7	40	months	month	NOUN
admet-2774	7	41	,	,	PUNCT
admet-2774	7	42	indicating	indicate	VERB
admet-2774	7	43	robust	robust	ADJ
admet-2774	7	44	colloidal	colloidal	NOUN
admet-2774	7	45	stability	stability	NOUN
admet-2774	7	46	.	.	PUNCT
admet-2774	8	1	a	a	DET
admet-2774	8	2	scanning	scanning	NOUN
admet-2774	8	3	electron	electron	NOUN
admet-2774	8	4	microscopy	microscopy	NOUN
admet-2774	8	5	study	study	NOUN
admet-2774	8	6	revealed	reveal	VERB
admet-2774	8	7	rodshaped	rodshape	VERB
admet-2774	8	8	nanoparticles	nanoparticle	NOUN
admet-2774	8	9	with	with	ADP
admet-2774	8	10	smooth	smooth	ADJ
admet-2774	8	11	surfaces	surface	NOUN
admet-2774	8	12	.	.	PUNCT
admet-2774	9	1	lyophilization	lyophilization	NOUN
admet-2774	9	2	(	(	PUNCT
admet-2774	9	3	freeze	freeze	NOUN
admet-2774	9	4	-	-	PUNCT
admet-2774	9	5	drying	dry	VERB
admet-2774	9	6	)	)	PUNCT
admet-2774	9	7	enhanced	enhance	VERB
admet-2774	9	8	long	long	ADJ
admet-2774	9	9	-	-	PUNCT
admet-2774	9	10	term	term	NOUN
admet-2774	9	11	stability	stability	NOUN
admet-2774	9	12	,	,	PUNCT
admet-2774	9	13	yielding	yield	VERB
admet-2774	9	14	a	a	DET
admet-2774	9	15	readily	readily	ADV
admet-2774	9	16	re	re	ADJ
admet-2774	9	17	-	-	ADJ
admet-2774	9	18	dispersible	dispersible	ADJ
admet-2774	9	19	powder	powder	NOUN
admet-2774	9	20	(	(	PUNCT
admet-2774	9	21	reconstitution	reconstitution	NOUN
admet-2774	9	22	index	index	NOUN
admet-2774	9	23	1.066	1.066	PROPN
admet-2774	9	24	)	)	PUNCT
admet-2774	9	25	.	.	PUNCT
admet-2774	10	1	following	follow	VERB
admet-2774	10	2	diffusion	diffusion	NOUN
admet-2774	10	3	-	-	PUNCT
admet-2774	10	4	controlled	control	VERB
admet-2774	10	5	kinetics	kinetic	NOUN
admet-2774	10	6	,	,	PUNCT
admet-2774	10	7	in	in	ADP
admet-2774	10	8	vitro	vitro	X
admet-2774	10	9	drug	drug	NOUN
admet-2774	10	10	release	release	NOUN
admet-2774	10	11	studies	study	NOUN
admet-2774	10	12	in	in	ADP
admet-2774	10	13	phosphate	phosphate	ADJ
admet-2774	10	14	buffer	buffer	NOUN
admet-2774	10	15	saline	saline	NOUN
admet-2774	10	16	(	(	PUNCT
admet-2774	10	17	ph	ph	NOUN
admet-2774	10	18	7.4	7.4	NUM
admet-2774	10	19	)	)	PUNCT
admet-2774	10	20	showed	show	VERB
admet-2774	10	21	sustained	sustained	ADJ
admet-2774	10	22	drug	drug	NOUN
admet-2774	10	23	release	release	NOUN
admet-2774	10	24	(	(	PUNCT
admet-2774	10	25	92.45	92.45	NUM
admet-2774	10	26	%	%	NOUN
admet-2774	10	27	cumulative	cumulative	ADJ
admet-2774	10	28	release	release	NOUN
admet-2774	10	29	over	over	ADP
admet-2774	10	30	48	48	NUM
admet-2774	10	31	h	h	NOUN
admet-2774	10	32	)	)	PUNCT
admet-2774	10	33	.	.	PUNCT
admet-2774	11	1	conclusion	conclusion	NOUN
admet-2774	11	2	:	:	PUNCT
admet-2774	11	3	our	our	PRON
admet-2774	11	4	results	result	NOUN
admet-2774	11	5	confirm	confirm	VERB
admet-2774	11	6	that	that	SCONJ
admet-2774	11	7	the	the	DET
admet-2774	11	8	inh	inh	NOUN
admet-2774	11	9	-	-	PUNCT
admet-2774	11	10	loaded	load	VERB
admet-2774	11	11	pcl	pcl	PROPN
admet-2774	11	12	nanoformulation	nanoformulation	NOUN
admet-2774	11	13	combines	combine	VERB
admet-2774	11	14	excellent	excellent	ADJ
admet-2774	11	15	stability	stability	NOUN
admet-2774	11	16	,	,	PUNCT
admet-2774	11	17	high	high	ADJ
admet-2774	11	18	drug	drug	NOUN
admet-2774	11	19	-	-	PUNCT
admet-2774	11	20	loading	loading	NOUN
admet-2774	11	21	capacity	capacity	NOUN
admet-2774	11	22	,	,	PUNCT
admet-2774	11	23	and	and	CCONJ
admet-2774	11	24	sustained	sustained	ADJ
admet-2774	11	25	release	release	NOUN
admet-2774	11	26	,	,	PUNCT
admet-2774	11	27	key	key	ADJ
admet-2774	11	28	attributes	attribute	NOUN
admet-2774	11	29	of	of	ADP
admet-2774	11	30	effective	effective	ADJ
admet-2774	11	31	tuberculosis	tuberculosis	NOUN
admet-2774	11	32	therapy	therapy	NOUN
admet-2774	11	33	.	.	PUNCT
admet-2774	12	1	©	©	PROPN
admet-2774	12	2	2025	2025	NUM
admet-2774	12	3	by	by	ADP
admet-2774	12	4	the	the	DET
admet-2774	12	5	authors	author	NOUN
admet-2774	12	6	.	.	PUNCT
admet-2774	13	1	this	this	DET
admet-2774	13	2	article	article	NOUN
admet-2774	13	3	is	be	AUX
admet-2774	13	4	an	an	DET
admet-2774	13	5	open	open	ADJ
admet-2774	13	6	-	-	PUNCT
admet-2774	13	7	access	access	NOUN
admet-2774	13	8	article	article	NOUN
admet-2774	13	9	distributed	distribute	VERB
admet-2774	13	10	under	under	ADP
admet-2774	13	11	the	the	DET
admet-2774	13	12	terms	term	NOUN
admet-2774	13	13	and	and	CCONJ
admet-2774	13	14	conditions	condition	NOUN
admet-2774	13	15	of	of	ADP
admet-2774	13	16	the	the	DET
admet-2774	13	17	creative	creative	ADJ
admet-2774	13	18	commons	common	NOUN
admet-2774	13	19	attribution	attribution	NOUN
admet-2774	13	20	license	license	NOUN
admet-2774	13	21	(	(	PUNCT
admet-2774	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2774	13	23	)	)	PUNCT
admet-2774	13	24	.	.	PUNCT
admet-2774	14	1	keywords	keyword	NOUN
admet-2774	14	2	lyophilization	lyophilization	NOUN
admet-2774	14	3	;	;	PUNCT
admet-2774	14	4	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	14	5	;	;	PUNCT
admet-2774	14	6	microreactor	microreactor	NOUN
admet-2774	14	7	,	,	PUNCT
admet-2774	14	8	sustained	sustained	ADJ
admet-2774	14	9	release	release	NOUN
admet-2774	14	10	;	;	PUNCT
admet-2774	14	11	pulmonary	pulmonary	ADJ
admet-2774	14	12	tuberculosis	tuberculosis	NOUN
admet-2774	14	13	introduction	introduction	NOUN
admet-2774	14	14	tuberculosis	tuberculosis	NOUN
admet-2774	14	15	(	(	PUNCT
admet-2774	14	16	tb	tb	NOUN
admet-2774	14	17	)	)	PUNCT
admet-2774	14	18	,	,	PUNCT
admet-2774	14	19	a	a	DET
admet-2774	14	20	life	life	NOUN
admet-2774	14	21	-	-	PUNCT
admet-2774	14	22	threatening	threaten	VERB
admet-2774	14	23	respiratory	respiratory	ADJ
admet-2774	14	24	infection	infection	NOUN
admet-2774	14	25	caused	cause	VERB
admet-2774	14	26	by	by	ADP
admet-2774	14	27	mycobacterium	mycobacterium	NOUN
admet-2774	14	28	tuberculosis	tuberculosis	NOUN
admet-2774	14	29	(	(	PUNCT
admet-2774	14	30	mtb	mtb	NOUN
admet-2774	14	31	)	)	PUNCT
admet-2774	14	32	,	,	PUNCT
admet-2774	14	33	continues	continue	VERB
admet-2774	14	34	to	to	PART
admet-2774	14	35	pose	pose	VERB
admet-2774	14	36	a	a	DET
admet-2774	14	37	significant	significant	ADJ
admet-2774	14	38	global	global	ADJ
admet-2774	14	39	health	health	NOUN
admet-2774	14	40	burden	burden	NOUN
admet-2774	14	41	.	.	PUNCT
admet-2774	15	1	the	the	DET
admet-2774	15	2	world	world	PROPN
admet-2774	15	3	health	health	PROPN
admet-2774	15	4	organization	organization	NOUN
admet-2774	15	5	's	's	PART
admet-2774	15	6	2024	2024	NUM
admet-2774	15	7	report	report	NOUN
admet-2774	15	8	documented	document	VERB
admet-2774	15	9	10.8	10.8	NUM
admet-2774	15	10	million	million	NUM
admet-2774	15	11	new	new	ADJ
admet-2774	15	12	tb	tb	ADP
admet-2774	15	13	cases	case	NOUN
admet-2774	15	14	and	and	CCONJ
admet-2774	15	15	1.25	1.25	NUM
admet-2774	15	16	million	million	NUM
admet-2774	15	17	fatalities	fatality	NOUN
admet-2774	15	18	in	in	ADP
admet-2774	15	19	2023	2023	NUM
admet-2774	15	20	,	,	PUNCT
admet-2774	15	21	underscoring	underscore	VERB
admet-2774	15	22	the	the	DET
admet-2774	15	23	urgent	urgent	ADJ
admet-2774	15	24	need	need	NOUN
admet-2774	15	25	for	for	ADP
admet-2774	15	26	improved	improved	ADJ
admet-2774	15	27	treatments	treatment	NOUN
admet-2774	15	28	[	[	X
admet-2774	15	29	1	1	NUM
admet-2774	15	30	-	-	SYM
admet-2774	15	31	3	3	NUM
admet-2774	15	32	]	]	PUNCT
admet-2774	15	33	.	.	PUNCT
admet-2774	16	1	the	the	DET
admet-2774	16	2	tb	tb	PROPN
admet-2774	16	3	infection	infection	NOUN
admet-2774	16	4	cycle	cycle	NOUN
admet-2774	16	5	begins	begin	VERB
admet-2774	16	6	when	when	SCONJ
admet-2774	16	7	aerosolized	aerosolized	ADJ
admet-2774	16	8	mtb	mtb	NOUN
admet-2774	16	9	bacilli	bacilli	NOUN
admet-2774	16	10	from	from	ADP
admet-2774	16	11	an	an	DET
admet-2774	16	12	active	active	ADJ
admet-2774	16	13	case	case	NOUN
admet-2774	16	14	are	be	AUX
admet-2774	16	15	inhaled	inhale	VERB
admet-2774	16	16	into	into	ADP
admet-2774	16	17	the	the	DET
admet-2774	16	18	lungs	lung	NOUN
admet-2774	16	19	of	of	ADP
admet-2774	16	20	a	a	DET
admet-2774	16	21	new	new	ADJ
admet-2774	16	22	host	host	NOUN
admet-2774	16	23	.	.	PUNCT
admet-2774	17	1	upon	upon	SCONJ
admet-2774	17	2	reaching	reach	VERB
admet-2774	17	3	the	the	DET
admet-2774	17	4	alveoli	alveolus	NOUN
admet-2774	17	5	,	,	PUNCT
admet-2774	17	6	the	the	DET
admet-2774	17	7	bacteria	bacteria	NOUN
admet-2774	17	8	are	be	AUX
admet-2774	17	9	phagocytosed	phagocytose	VERB
admet-2774	17	10	by	by	ADP
admet-2774	17	11	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	NOUN
admet-2774	17	12	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	NOUN
admet-2774	17	13	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	X
admet-2774	17	14	mailto:jitunaik@gmail.com	mailto:jitunaik@gmail.com	X
admet-2774	18	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2774	18	2	e.	e.	PROPN
admet-2774	18	3	kole	kole	PROPN
admet-2774	18	4	et	et	PROPN
admet-2774	18	5	al	al	PROPN
admet-2774	18	6	.	.	PROPN
admet-2774	18	7	admet	admet	PROPN
admet-2774	18	8	&	&	CCONJ
admet-2774	18	9	dmpk	dmpk	PROPN
admet-2774	18	10	13(4	13(4	NUM
admet-2774	18	11	)	)	PUNCT
admet-2774	18	12	(	(	PUNCT
admet-2774	18	13	2025	2025	NUM
admet-2774	18	14	)	)	PUNCT
admet-2774	18	15	2774	2774	NUM
admet-2774	18	16	2	2	NUM
admet-2774	18	17	macrophages	macrophage	NOUN
admet-2774	18	18	,	,	PUNCT
admet-2774	18	19	ultimately	ultimately	ADV
admet-2774	18	20	leading	lead	VERB
admet-2774	18	21	to	to	ADP
admet-2774	18	22	the	the	DET
admet-2774	18	23	development	development	NOUN
admet-2774	18	24	of	of	ADP
admet-2774	18	25	characteristic	characteristic	ADJ
admet-2774	18	26	granulomatous	granulomatous	ADJ
admet-2774	18	27	lesions	lesion	NOUN
admet-2774	18	28	where	where	SCONJ
admet-2774	18	29	the	the	DET
admet-2774	18	30	host	host	NOUN
admet-2774	18	31	attempts	attempt	VERB
admet-2774	18	32	to	to	PART
admet-2774	18	33	isolate	isolate	VERB
admet-2774	18	34	the	the	DET
admet-2774	18	35	persistent	persistent	ADJ
admet-2774	18	36	mycobacteria	mycobacteria	NOUN
admet-2774	18	37	[	[	X
admet-2774	18	38	4	4	NUM
admet-2774	18	39	]	]	PUNCT
admet-2774	18	40	.	.	PUNCT
admet-2774	19	1	the	the	DET
admet-2774	19	2	gradual	gradual	ADJ
admet-2774	19	3	breakdown	breakdown	NOUN
admet-2774	19	4	of	of	ADP
admet-2774	19	5	granuloma	granuloma	ADJ
admet-2774	19	6	integrity	integrity	NOUN
admet-2774	19	7	can	can	AUX
admet-2774	19	8	enable	enable	VERB
admet-2774	19	9	mtb	mtb	NOUN
admet-2774	19	10	reactivation	reactivation	NOUN
admet-2774	19	11	and	and	CCONJ
admet-2774	19	12	spread	spread	VERB
admet-2774	19	13	,	,	PUNCT
admet-2774	19	14	resulting	result	VERB
admet-2774	19	15	in	in	ADP
admet-2774	19	16	destructive	destructive	ADJ
admet-2774	19	17	cavitary	cavitary	ADJ
admet-2774	19	18	lung	lung	NOUN
admet-2774	19	19	lesions	lesion	NOUN
admet-2774	19	20	.	.	PUNCT
admet-2774	20	1	successful	successful	ADJ
admet-2774	20	2	tb	tb	ADP
admet-2774	20	3	treatment	treatment	NOUN
admet-2774	20	4	must	must	AUX
admet-2774	20	5	address	address	VERB
admet-2774	20	6	two	two	NUM
admet-2774	20	7	distinct	distinct	ADJ
admet-2774	20	8	bacterial	bacterial	ADJ
admet-2774	20	9	populations	population	NOUN
admet-2774	20	10	:	:	PUNCT
admet-2774	20	11	latent	latent	NOUN
admet-2774	20	12	organisms	organism	NOUN
admet-2774	20	13	within	within	ADP
admet-2774	20	14	granulomas	granuloma	NOUN
admet-2774	20	15	and	and	CCONJ
admet-2774	20	16	actively	actively	ADV
admet-2774	20	17	dividing	divide	VERB
admet-2774	20	18	bacilli	bacilli	NOUN
admet-2774	20	19	in	in	ADP
admet-2774	20	20	cavities	cavity	NOUN
admet-2774	20	21	,	,	PUNCT
admet-2774	20	22	highlighting	highlight	VERB
admet-2774	20	23	the	the	DET
admet-2774	20	24	need	need	NOUN
admet-2774	20	25	for	for	ADP
admet-2774	20	26	multifaceted	multifaceted	ADJ
admet-2774	20	27	therapeutic	therapeutic	ADJ
admet-2774	20	28	solutions	solution	NOUN
admet-2774	20	29	[	[	X
admet-2774	20	30	5	5	NUM
admet-2774	20	31	]	]	PUNCT
admet-2774	20	32	.	.	PUNCT
admet-2774	21	1	conventional	conventional	ADJ
admet-2774	21	2	tb	tb	ADP
admet-2774	21	3	treatment	treatment	NOUN
admet-2774	21	4	follows	follow	VERB
admet-2774	21	5	a	a	DET
admet-2774	21	6	two	two	NUM
admet-2774	21	7	-	-	PUNCT
admet-2774	21	8	phase	phase	NOUN
admet-2774	21	9	protocol	protocol	NOUN
admet-2774	21	10	,	,	PUNCT
admet-2774	21	11	beginning	begin	VERB
admet-2774	21	12	with	with	ADP
admet-2774	21	13	a	a	DET
admet-2774	21	14	2	2	NUM
admet-2774	21	15	-	-	PUNCT
admet-2774	21	16	month	month	NOUN
admet-2774	21	17	course	course	NOUN
admet-2774	21	18	of	of	ADP
admet-2774	21	19	four	four	NUM
admet-2774	21	20	first	first	ADJ
admet-2774	21	21	-	-	PUNCT
admet-2774	21	22	line	line	NOUN
admet-2774	21	23	drugs	drug	NOUN
admet-2774	21	24	(	(	PUNCT
admet-2774	21	25	isoniazid	isoniazid	NOUN
admet-2774	21	26	,	,	PUNCT
admet-2774	21	27	rifampicin	rifampicin	VERB
admet-2774	21	28	,	,	PUNCT
admet-2774	21	29	pyrazinamide	pyrazinamide	NOUN
admet-2774	21	30	,	,	PUNCT
admet-2774	21	31	and	and	CCONJ
admet-2774	21	32	ethambutol	ethambutol	ADJ
admet-2774	21	33	)	)	PUNCT
admet-2774	21	34	,	,	PUNCT
admet-2774	21	35	followed	follow	VERB
admet-2774	21	36	by	by	ADP
admet-2774	21	37	a	a	DET
admet-2774	21	38	4	4	NUM
admet-2774	21	39	-	-	PUNCT
admet-2774	21	40	month	month	NOUN
admet-2774	21	41	maintenance	maintenance	NOUN
admet-2774	21	42	phase	phase	NOUN
admet-2774	21	43	with	with	ADP
admet-2774	21	44	isoniazid	isoniazid	NOUN
admet-2774	21	45	and	and	CCONJ
admet-2774	21	46	rifampicin	rifampicin	VERB
admet-2774	21	47	[	[	X
admet-2774	21	48	6	6	NUM
admet-2774	21	49	]	]	PUNCT
admet-2774	21	50	.	.	PUNCT
admet-2774	22	1	the	the	DET
admet-2774	22	2	extended	extended	ADJ
admet-2774	22	3	4	4	NUM
admet-2774	22	4	to	to	PART
admet-2774	22	5	6	6	NUM
admet-2774	22	6	-	-	PUNCT
admet-2774	22	7	month	month	NOUN
admet-2774	22	8	treatment	treatment	NOUN
admet-2774	22	9	course	course	NOUN
admet-2774	22	10	and	and	CCONJ
admet-2774	22	11	substantial	substantial	ADJ
admet-2774	22	12	daily	daily	ADJ
admet-2774	22	13	medication	medication	NOUN
admet-2774	22	14	load	load	NOUN
admet-2774	22	15	frequently	frequently	ADV
admet-2774	22	16	result	result	VERB
admet-2774	22	17	in	in	ADP
admet-2774	22	18	therapeutic	therapeutic	ADJ
admet-2774	22	19	challenges	challenge	NOUN
admet-2774	22	20	.	.	PUNCT
admet-2774	23	1	these	these	PRON
admet-2774	23	2	include	include	VERB
admet-2774	23	3	decreased	decrease	VERB
admet-2774	23	4	patient	patient	ADJ
admet-2774	23	5	adherence	adherence	NOUN
admet-2774	23	6	caused	cause	VERB
admet-2774	23	7	by	by	ADP
admet-2774	23	8	adverse	adverse	ADJ
admet-2774	23	9	effects	effect	NOUN
admet-2774	23	10	and	and	CCONJ
admet-2774	23	11	pharmacological	pharmacological	ADJ
admet-2774	23	12	interactions	interaction	NOUN
admet-2774	23	13	,	,	PUNCT
admet-2774	23	14	which	which	PRON
admet-2774	23	15	may	may	AUX
admet-2774	23	16	contribute	contribute	VERB
admet-2774	23	17	to	to	ADP
admet-2774	23	18	unsuccessful	unsuccessful	ADJ
admet-2774	23	19	treatment	treatment	NOUN
admet-2774	23	20	outcomes	outcome	NOUN
admet-2774	23	21	and	and	CCONJ
admet-2774	23	22	the	the	DET
admet-2774	23	23	emergence	emergence	NOUN
admet-2774	23	24	of	of	ADP
admet-2774	23	25	drug	drug	NOUN
admet-2774	23	26	-	-	PUNCT
admet-2774	23	27	resistant	resistant	ADJ
admet-2774	23	28	tuberculosis	tuberculosis	NOUN
admet-2774	23	29	strains	strain	NOUN
admet-2774	23	30	[	[	X
admet-2774	23	31	7	7	NUM
admet-2774	23	32	]	]	PUNCT
admet-2774	23	33	.	.	PUNCT
admet-2774	24	1	several	several	ADJ
admet-2774	24	2	factors	factor	NOUN
admet-2774	24	3	complicate	complicate	VERB
admet-2774	24	4	tuberculosis	tuberculosis	NOUN
admet-2774	24	5	treatment	treatment	NOUN
admet-2774	24	6	adherence	adherence	NOUN
admet-2774	24	7	,	,	PUNCT
admet-2774	24	8	including	include	VERB
admet-2774	24	9	the	the	DET
admet-2774	24	10	requirement	requirement	NOUN
admet-2774	24	11	for	for	ADP
admet-2774	24	12	multi	multi	ADJ
admet-2774	24	13	-	-	ADJ
admet-2774	24	14	drug	drug	ADJ
admet-2774	24	15	regimens	regimen	NOUN
admet-2774	24	16	,	,	PUNCT
admet-2774	24	17	significant	significant	ADJ
admet-2774	24	18	treatment	treatment	NOUN
admet-2774	24	19	expenses	expense	NOUN
admet-2774	24	20	,	,	PUNCT
admet-2774	24	21	and	and	CCONJ
admet-2774	24	22	undesirable	undesirable	ADJ
admet-2774	24	23	medication	medication	NOUN
admet-2774	24	24	effects	effect	NOUN
admet-2774	24	25	.	.	PUNCT
admet-2774	25	1	these	these	DET
admet-2774	25	2	challenges	challenge	NOUN
admet-2774	25	3	are	be	AUX
admet-2774	25	4	exacerbated	exacerbate	VERB
admet-2774	25	5	by	by	ADP
admet-2774	25	6	the	the	DET
admet-2774	25	7	poor	poor	ADJ
admet-2774	25	8	taste	taste	NOUN
admet-2774	25	9	of	of	ADP
admet-2774	25	10	many	many	ADJ
admet-2774	25	11	antitubercular	antitubercular	ADJ
admet-2774	25	12	formulations	formulation	NOUN
admet-2774	25	13	,	,	PUNCT
admet-2774	25	14	creating	create	VERB
admet-2774	25	15	particular	particular	ADJ
admet-2774	25	16	difficulties	difficulty	NOUN
admet-2774	25	17	for	for	ADP
admet-2774	25	18	children	child	NOUN
admet-2774	25	19	and	and	CCONJ
admet-2774	25	20	often	often	ADV
admet-2774	25	21	resulting	result	VERB
admet-2774	25	22	in	in	ADP
admet-2774	25	23	skipped	skip	VERB
admet-2774	25	24	medications	medication	NOUN
admet-2774	25	25	that	that	PRON
admet-2774	25	26	may	may	AUX
admet-2774	25	27	compromise	compromise	VERB
admet-2774	25	28	treatment	treatment	NOUN
admet-2774	25	29	success	success	NOUN
admet-2774	25	30	[	[	X
admet-2774	25	31	8,9	8,9	NUM
admet-2774	25	32	]	]	PUNCT
admet-2774	25	33	.	.	PUNCT
admet-2774	26	1	clinical	clinical	ADJ
admet-2774	26	2	studies	study	NOUN
admet-2774	26	3	indicate	indicate	VERB
admet-2774	26	4	that	that	SCONJ
admet-2774	26	5	over	over	ADP
admet-2774	26	6	10	10	NUM
admet-2774	26	7	%	%	NOUN
admet-2774	26	8	of	of	ADP
admet-2774	26	9	tuberculosis	tuberculosis	NOUN
admet-2774	26	10	patients	patient	NOUN
admet-2774	26	11	undergoing	undergo	VERB
admet-2774	26	12	conventional	conventional	ADJ
admet-2774	26	13	first	first	ADJ
admet-2774	26	14	-	-	PUNCT
admet-2774	26	15	line	line	NOUN
admet-2774	26	16	treatment	treatment	NOUN
admet-2774	26	17	(	(	PUNCT
admet-2774	26	18	including	include	VERB
admet-2774	26	19	isoniazid	isoniazid	NOUN
admet-2774	26	20	therapy	therapy	NOUN
admet-2774	26	21	)	)	PUNCT
admet-2774	26	22	terminate	terminate	VERB
admet-2774	26	23	their	their	PRON
admet-2774	26	24	regimens	regimen	NOUN
admet-2774	26	25	hastily	hastily	ADV
admet-2774	26	26	due	due	ADP
admet-2774	26	27	to	to	ADP
admet-2774	26	28	medication	medication	NOUN
admet-2774	26	29	-	-	PUNCT
admet-2774	26	30	related	relate	VERB
admet-2774	26	31	complications	complication	NOUN
admet-2774	26	32	,	,	PUNCT
admet-2774	26	33	particularly	particularly	ADV
admet-2774	26	34	peripheral	peripheral	ADJ
admet-2774	26	35	nerve	nerve	NOUN
admet-2774	26	36	damage	damage	NOUN
admet-2774	26	37	and	and	CCONJ
admet-2774	26	38	liver	liver	NOUN
admet-2774	26	39	toxicity	toxicity	NOUN
admet-2774	26	40	[	[	X
admet-2774	26	41	10,11	10,11	NOUN
admet-2774	26	42	]	]	PUNCT
admet-2774	26	43	.	.	PUNCT
admet-2774	27	1	advances	advance	NOUN
admet-2774	27	2	in	in	ADP
admet-2774	27	3	pharmaceutical	pharmaceutical	ADJ
admet-2774	27	4	engineering	engineering	NOUN
admet-2774	27	5	have	have	AUX
admet-2774	27	6	facilitated	facilitate	VERB
admet-2774	27	7	the	the	DET
admet-2774	27	8	design	design	NOUN
admet-2774	27	9	of	of	ADP
admet-2774	27	10	innovative	innovative	ADJ
admet-2774	27	11	drug	drug	NOUN
admet-2774	27	12	delivery	delivery	NOUN
admet-2774	27	13	platforms	platform	NOUN
admet-2774	27	14	,	,	PUNCT
admet-2774	27	15	including	include	VERB
admet-2774	27	16	nanoparticle	nanoparticle	NOUN
admet-2774	27	17	-	-	PUNCT
admet-2774	27	18	based	base	VERB
admet-2774	27	19	carriers	carrier	NOUN
admet-2774	27	20	,	,	PUNCT
admet-2774	27	21	lipid	lipid	NOUN
admet-2774	27	22	vesicles	vesicle	NOUN
admet-2774	27	23	,	,	PUNCT
admet-2774	27	24	and	and	CCONJ
admet-2774	27	25	polymeric	polymeric	ADJ
admet-2774	27	26	microparticles	microparticle	NOUN
admet-2774	27	27	[	[	X
admet-2774	27	28	12	12	NUM
admet-2774	27	29	-	-	SYM
admet-2774	27	30	17	17	NUM
admet-2774	27	31	]	]	PUNCT
admet-2774	27	32	.	.	PUNCT
admet-2774	28	1	these	these	DET
admet-2774	28	2	systems	system	NOUN
admet-2774	28	3	enable	enable	VERB
admet-2774	28	4	the	the	DET
admet-2774	28	5	controlled	control	VERB
admet-2774	28	6	co	co	NOUN
admet-2774	28	7	-	-	NOUN
admet-2774	28	8	delivery	delivery	NOUN
admet-2774	28	9	of	of	ADP
admet-2774	28	10	multiple	multiple	ADJ
admet-2774	28	11	therapeutic	therapeutic	ADJ
admet-2774	28	12	agents	agent	NOUN
admet-2774	28	13	with	with	ADP
admet-2774	28	14	prolonged	prolong	VERB
admet-2774	28	15	release	release	NOUN
admet-2774	28	16	kinetics	kinetic	NOUN
admet-2774	28	17	[	[	X
admet-2774	28	18	18,19	18,19	NUM
admet-2774	28	19	]	]	PUNCT
admet-2774	28	20	.	.	PUNCT
admet-2774	29	1	engineered	engineer	VERB
admet-2774	29	2	nanodelivery	nanodelivery	NOUN
admet-2774	29	3	systems	system	NOUN
admet-2774	29	4	demonstrate	demonstrate	VERB
admet-2774	29	5	superior	superior	ADJ
admet-2774	29	6	drug	drug	NOUN
admet-2774	29	7	-	-	PUNCT
admet-2774	29	8	carrying	carry	VERB
admet-2774	29	9	capacity	capacity	NOUN
admet-2774	29	10	,	,	PUNCT
admet-2774	29	11	programmable	programmable	ADJ
admet-2774	29	12	release	release	NOUN
admet-2774	29	13	kinetics	kinetic	NOUN
admet-2774	29	14	,	,	PUNCT
admet-2774	29	15	and	and	CCONJ
admet-2774	29	16	precise	precise	ADJ
admet-2774	29	17	tissue	tissue	NOUN
admet-2774	29	18	targeting	target	VERB
admet-2774	29	19	while	while	SCONJ
admet-2774	29	20	meeting	meet	VERB
admet-2774	29	21	stringent	stringent	ADJ
admet-2774	29	22	biocompatibility	biocompatibility	NOUN
admet-2774	29	23	requirements	requirement	NOUN
admet-2774	29	24	for	for	ADP
admet-2774	29	25	medical	medical	ADJ
admet-2774	29	26	use	use	NOUN
admet-2774	29	27	[	[	X
admet-2774	29	28	20,21	20,21	NUM
admet-2774	29	29	]	]	PUNCT
admet-2774	29	30	.	.	PUNCT
admet-2774	30	1	the	the	DET
admet-2774	30	2	development	development	NOUN
admet-2774	30	3	of	of	ADP
admet-2774	30	4	polymeric	polymeric	ADJ
admet-2774	30	5	nanocarriers	nanocarrier	NOUN
admet-2774	30	6	has	have	AUX
admet-2774	30	7	introduced	introduce	VERB
admet-2774	30	8	new	new	ADJ
admet-2774	30	9	possibilities	possibility	NOUN
admet-2774	30	10	for	for	ADP
admet-2774	30	11	precision	precision	NOUN
admet-2774	30	12	medicine	medicine	NOUN
admet-2774	30	13	.	.	PUNCT
admet-2774	31	1	their	their	PRON
admet-2774	31	2	biodegradable	biodegradable	ADJ
admet-2774	31	3	composition	composition	NOUN
admet-2774	31	4	capitalizes	capitalize	VERB
admet-2774	31	5	on	on	ADP
admet-2774	31	6	physiological	physiological	ADJ
admet-2774	31	7	transport	transport	NOUN
admet-2774	31	8	mechanisms	mechanism	NOUN
admet-2774	31	9	,	,	PUNCT
admet-2774	31	10	including	include	VERB
admet-2774	31	11	vascular	vascular	ADJ
admet-2774	31	12	leakiness	leakiness	NOUN
admet-2774	31	13	in	in	ADP
admet-2774	31	14	diseased	diseased	ADJ
admet-2774	31	15	tissues	tissue	NOUN
admet-2774	31	16	,	,	PUNCT
admet-2774	31	17	to	to	PART
admet-2774	31	18	enhance	enhance	VERB
admet-2774	31	19	drug	drug	NOUN
admet-2774	31	20	localization	localization	NOUN
admet-2774	31	21	while	while	SCONJ
admet-2774	31	22	sustaining	sustain	VERB
admet-2774	31	23	therapeutic	therapeutic	ADJ
admet-2774	31	24	plasma	plasma	NOUN
admet-2774	31	25	levels	level	NOUN
admet-2774	31	26	through	through	ADP
admet-2774	31	27	prolonged	prolonged	ADJ
admet-2774	31	28	circulation	circulation	NOUN
admet-2774	31	29	kinetics	kinetic	NOUN
admet-2774	32	1	[	[	PUNCT
admet-2774	32	2	22	22	NUM
admet-2774	32	3	-	-	SYM
admet-2774	32	4	24	24	NUM
admet-2774	32	5	]	]	PUNCT
admet-2774	32	6	.	.	PUNCT
admet-2774	33	1	among	among	ADP
admet-2774	33	2	synthetic	synthetic	ADJ
admet-2774	33	3	biodegradable	biodegradable	ADJ
admet-2774	33	4	polymers	polymer	NOUN
admet-2774	33	5	,	,	PUNCT
admet-2774	33	6	poly	poly	NOUN
admet-2774	33	7	-	-	PUNCT
admet-2774	33	8	ε	ε	NOUN
admet-2774	33	9	-	-	PUNCT
admet-2774	33	10	caprolactone	caprolactone	NOUN
admet-2774	33	11	(	(	PUNCT
admet-2774	33	12	pcl	pcl	PROPN
admet-2774	33	13	)	)	PUNCT
admet-2774	33	14	stands	stand	VERB
admet-2774	33	15	out	out	ADP
admet-2774	33	16	for	for	ADP
admet-2774	33	17	drug	drug	NOUN
admet-2774	33	18	delivery	delivery	NOUN
admet-2774	33	19	applications	application	NOUN
admet-2774	33	20	due	due	ADP
admet-2774	33	21	to	to	ADP
admet-2774	33	22	its	its	PRON
admet-2774	33	23	unique	unique	ADJ
admet-2774	33	24	pharmaceutical	pharmaceutical	ADJ
admet-2774	33	25	advantages	advantage	NOUN
admet-2774	33	26	.	.	PUNCT
admet-2774	34	1	its	its	PRON
admet-2774	34	2	demonstrated	demonstrate	VERB
admet-2774	34	3	safety	safety	NOUN
admet-2774	34	4	profile	profile	NOUN
admet-2774	34	5	,	,	PUNCT
admet-2774	34	6	predictable	predictable	ADJ
admet-2774	34	7	degradation	degradation	NOUN
admet-2774	34	8	behaviour	behaviour	NOUN
admet-2774	34	9	,	,	PUNCT
admet-2774	34	10	and	and	CCONJ
admet-2774	34	11	formulation	formulation	NOUN
admet-2774	34	12	flexibility	flexibility	NOUN
admet-2774	34	13	make	make	VERB
admet-2774	34	14	it	it	PRON
admet-2774	34	15	ideal	ideal	ADJ
admet-2774	34	16	for	for	ADP
admet-2774	34	17	nanoparticle	nanoparticle	NOUN
admet-2774	34	18	development	development	NOUN
admet-2774	34	19	.	.	PUNCT
admet-2774	35	1	researchers	researcher	NOUN
admet-2774	35	2	particularly	particularly	ADV
admet-2774	35	3	value	value	VERB
admet-2774	35	4	pcl	pcl	PROPN
admet-2774	35	5	's	's	PART
admet-2774	35	6	hydrophobic	hydrophobic	NOUN
admet-2774	35	7	nature	nature	NOUN
admet-2774	35	8	and	and	CCONJ
admet-2774	35	9	permeability	permeability	NOUN
admet-2774	35	10	characteristics	characteristic	NOUN
admet-2774	35	11	for	for	ADP
admet-2774	35	12	sustained	sustained	ADJ
admet-2774	35	13	drug	drug	NOUN
admet-2774	35	14	delivery	delivery	NOUN
admet-2774	35	15	.	.	PUNCT
admet-2774	36	1	notably	notably	ADV
admet-2774	36	2	,	,	PUNCT
admet-2774	36	3	its	its	PRON
admet-2774	36	4	degradation	degradation	NOUN
admet-2774	36	5	yields	yield	VERB
admet-2774	36	6	6	6	NUM
admet-2774	36	7	-	-	PUNCT
admet-2774	36	8	hydroxycaproic	hydroxycaproic	ADJ
admet-2774	36	9	acid	acid	NOUN
admet-2774	36	10	,	,	PUNCT
admet-2774	36	11	a	a	DET
admet-2774	36	12	biologically	biologically	ADV
admet-2774	36	13	benign	benign	ADJ
admet-2774	36	14	byproduct	byproduct	NOUN
admet-2774	36	15	that	that	PRON
admet-2774	36	16	preserves	preserve	VERB
admet-2774	36	17	local	local	ADJ
admet-2774	36	18	ph	ph	ADJ
admet-2774	36	19	stability	stability	NOUN
admet-2774	36	20	[	[	X
admet-2774	36	21	25,26	25,26	X
admet-2774	36	22	]	]	PUNCT
admet-2774	36	23	.	.	PUNCT
admet-2774	37	1	implementing	implement	VERB
admet-2774	37	2	qbd	qbd	NOUN
admet-2774	37	3	principles	principle	NOUN
admet-2774	37	4	in	in	ADP
admet-2774	37	5	nanoparticle	nanoparticle	NOUN
admet-2774	37	6	development	development	NOUN
admet-2774	37	7	allows	allow	VERB
admet-2774	37	8	for	for	ADP
admet-2774	37	9	a	a	DET
admet-2774	37	10	comprehensive	comprehensive	ADJ
admet-2774	37	11	evaluation	evaluation	NOUN
admet-2774	37	12	of	of	ADP
admet-2774	37	13	critical	critical	ADJ
admet-2774	37	14	quality	quality	NOUN
admet-2774	37	15	attributes	attribute	NOUN
admet-2774	37	16	.	.	PUNCT
admet-2774	38	1	through	through	ADP
admet-2774	38	2	design	design	NOUN
admet-2774	38	3	of	of	ADP
admet-2774	38	4	experiments	experiment	NOUN
admet-2774	38	5	(	(	PUNCT
admet-2774	38	6	doe	doe	NOUN
admet-2774	38	7	)	)	PUNCT
admet-2774	38	8	methodologies	methodology	NOUN
admet-2774	38	9	,	,	PUNCT
admet-2774	38	10	formulators	formulator	NOUN
admet-2774	38	11	can	can	AUX
admet-2774	38	12	simultaneously	simultaneously	ADV
admet-2774	38	13	(	(	PUNCT
admet-2774	38	14	i	i	NOUN
admet-2774	38	15	)	)	PUNCT
admet-2774	38	16	determine	determine	VERB
admet-2774	38	17	essential	essential	ADJ
admet-2774	38	18	process	process	NOUN
admet-2774	38	19	parameters	parameter	NOUN
admet-2774	38	20	,	,	PUNCT
admet-2774	38	21	(	(	PUNCT
admet-2774	38	22	ii	ii	NOUN
admet-2774	38	23	)	)	PUNCT
admet-2774	38	24	minimize	minimize	VERB
admet-2774	38	25	required	require	VERB
admet-2774	38	26	experimental	experimental	ADJ
admet-2774	38	27	runs	run	NOUN
admet-2774	38	28	,	,	PUNCT
admet-2774	38	29	and	and	CCONJ
admet-2774	38	30	(	(	PUNCT
admet-2774	38	31	iii	iii	NOUN
admet-2774	38	32	)	)	PUNCT
admet-2774	38	33	assess	assess	NOUN
admet-2774	38	34	multivariate	multivariate	NOUN
admet-2774	38	35	factor	factor	NOUN
admet-2774	38	36	relationships	relationship	NOUN
admet-2774	38	37	,	,	PUNCT
admet-2774	38	38	significantly	significantly	ADV
admet-2774	38	39	streamlining	streamline	VERB
admet-2774	38	40	nanomedicine	nanomedicine	ADJ
admet-2774	38	41	development	development	NOUN
admet-2774	39	1	[	[	X
admet-2774	39	2	27	27	NUM
admet-2774	39	3	]	]	PUNCT
admet-2774	39	4	.	.	PUNCT
admet-2774	40	1	this	this	DET
admet-2774	40	2	study	study	NOUN
admet-2774	40	3	introduced	introduce	VERB
admet-2774	40	4	a	a	DET
admet-2774	40	5	novel	novel	ADJ
admet-2774	40	6	approach	approach	NOUN
admet-2774	40	7	by	by	ADP
admet-2774	40	8	combining	combine	VERB
admet-2774	40	9	microreactor	microreactor	NOUN
admet-2774	40	10	-	-	PUNCT
admet-2774	40	11	assisted	assist	VERB
admet-2774	40	12	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	40	13	with	with	ADP
admet-2774	40	14	freeze	freeze	NOUN
admet-2774	40	15	-	-	PUNCT
admet-2774	40	16	drying	dry	VERB
admet-2774	40	17	to	to	PART
admet-2774	40	18	fabricate	fabricate	VERB
admet-2774	40	19	and	and	CCONJ
admet-2774	40	20	optimize	optimize	VERB
admet-2774	40	21	isoniazid	isoniazid	NOUN
admet-2774	40	22	(	(	PUNCT
admet-2774	40	23	inh)-loaded	inh)-loade	VERB
admet-2774	40	24	pcl	pcl	PROPN
admet-2774	40	25	nanoparticles	nanoparticle	NOUN
admet-2774	40	26	(	(	PUNCT
admet-2774	40	27	nps	nps	PROPN
admet-2774	40	28	)	)	PUNCT
admet-2774	40	29	.	.	PUNCT
admet-2774	41	1	this	this	DET
admet-2774	41	2	strategy	strategy	NOUN
admet-2774	41	3	leverages	leverage	VERB
admet-2774	41	4	the	the	DET
admet-2774	41	5	precision	precision	NOUN
admet-2774	41	6	of	of	ADP
admet-2774	41	7	microreactors	microreactor	NOUN
admet-2774	41	8	to	to	PART
admet-2774	41	9	achieve	achieve	VERB
admet-2774	41	10	monodisperse	monodisperse	PROPN
admet-2774	41	11	nps	nps	PROPN
admet-2774	41	12	with	with	ADP
admet-2774	41	13	high	high	ADJ
admet-2774	41	14	drug	drug	NOUN
admet-2774	41	15	encapsulation	encapsulation	NOUN
admet-2774	41	16	efficiency	efficiency	NOUN
admet-2774	41	17	(	(	PUNCT
admet-2774	41	18	ee	ee	NOUN
admet-2774	41	19	)	)	PUNCT
admet-2774	41	20	while	while	SCONJ
admet-2774	41	21	ensuring	ensure	VERB
admet-2774	41	22	long	long	ADJ
admet-2774	41	23	-	-	PUNCT
admet-2774	41	24	term	term	NOUN
admet-2774	41	25	stability	stability	NOUN
admet-2774	41	26	through	through	ADP
admet-2774	41	27	lyophilization	lyophilization	NOUN
admet-2774	41	28	critical	critical	ADJ
admet-2774	41	29	advancement	advancement	NOUN
admet-2774	41	30	for	for	ADP
admet-2774	41	31	clinical	clinical	ADJ
admet-2774	41	32	translation	translation	NOUN
admet-2774	41	33	.	.	PUNCT
admet-2774	42	1	this	this	DET
admet-2774	42	2	work	work	NOUN
admet-2774	42	3	aims	aim	VERB
admet-2774	42	4	to	to	PART
admet-2774	42	5	systematically	systematically	ADV
admet-2774	42	6	develop	develop	VERB
admet-2774	42	7	and	and	CCONJ
admet-2774	42	8	characterize	characterize	VERB
admet-2774	42	9	freeze	freeze	NOUN
admet-2774	42	10	-	-	PUNCT
admet-2774	42	11	dried	dry	VERB
admet-2774	42	12	inh	inh	NOUN
admet-2774	42	13	-	-	PUNCT
admet-2774	42	14	loaded	load	VERB
admet-2774	42	15	pcl	pcl	PROPN
admet-2774	42	16	nanoparticles	nanoparticle	NOUN
admet-2774	42	17	,	,	PUNCT
admet-2774	42	18	optimizing	optimize	VERB
admet-2774	42	19	key	key	ADJ
admet-2774	42	20	parameters	parameter	NOUN
admet-2774	42	21	like	like	ADP
admet-2774	42	22	flow	flow	NOUN
admet-2774	42	23	rate	rate	NOUN
admet-2774	42	24	,	,	PUNCT
admet-2774	42	25	polymer	polymer	NOUN
admet-2774	42	26	-	-	PUNCT
admet-2774	42	27	drug	drug	NOUN
admet-2774	42	28	ratio	ratio	NOUN
admet-2774	42	29	and	and	CCONJ
admet-2774	42	30	surfactant	surfactant	ADJ
admet-2774	42	31	concentration	concentration	NOUN
admet-2774	42	32	to	to	PART
admet-2774	42	33	enhance	enhance	VERB
admet-2774	42	34	nanoparticle	nanoparticle	NOUN
admet-2774	42	35	properties	property	NOUN
admet-2774	42	36	such	such	ADJ
admet-2774	42	37	as	as	ADP
admet-2774	42	38	particle	particle	NOUN
admet-2774	42	39	size	size	NOUN
admet-2774	42	40	,	,	PUNCT
admet-2774	42	41	zeta	zeta	NOUN
admet-2774	42	42	potential	potential	NOUN
admet-2774	42	43	,	,	PUNCT
admet-2774	42	44	ee	ee	NOUN
admet-2774	42	45	and	and	CCONJ
admet-2774	42	46	drug	drug	NOUN
admet-2774	42	47	release	release	NOUN
admet-2774	42	48	study	study	NOUN
admet-2774	42	49	.	.	PUNCT
admet-2774	43	1	microfluidic	microfluidic	ADJ
admet-2774	43	2	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	43	3	would	would	AUX
admet-2774	43	4	yield	yield	VERB
admet-2774	43	5	uniformly	uniformly	ADV
admet-2774	43	6	sized	sized	ADJ
admet-2774	43	7	,	,	PUNCT
admet-2774	43	8	stable	stable	ADJ
admet-2774	43	9	nps	nps	PROPN
admet-2774	43	10	,	,	PUNCT
admet-2774	43	11	and	and	CCONJ
admet-2774	43	12	freeze	freeze	NOUN
admet-2774	43	13	-	-	PUNCT
admet-2774	43	14	drying	drying	NOUN
admet-2774	43	15	will	will	AUX
admet-2774	43	16	preserve	preserve	VERB
admet-2774	43	17	their	their	PRON
admet-2774	43	18	physicochemical	physicochemical	ADJ
admet-2774	43	19	integrity	integrity	NOUN
admet-2774	43	20	without	without	ADP
admet-2774	43	21	compromising	compromise	VERB
admet-2774	43	22	admet	admet	PROPN
admet-2774	43	23	&	&	CCONJ
admet-2774	43	24	dmpk	dmpk	PROPN
admet-2774	43	25	13(4	13(4	NUM
admet-2774	43	26	)	)	PUNCT
admet-2774	43	27	(	(	PUNCT
admet-2774	43	28	2025	2025	NUM
admet-2774	43	29	)	)	PUNCT
admet-2774	43	30	2774	2774	NUM
admet-2774	43	31	freeze	freeze	NOUN
admet-2774	43	32	-	-	PUNCT
admet-2774	43	33	dried	dry	VERB
admet-2774	43	34	isoniazid	isoniazid	NOUN
admet-2774	43	35	-	-	PUNCT
admet-2774	43	36	loaded	load	VERB
admet-2774	43	37	poly	poly	ADJ
admet-2774	43	38	-	-	PUNCT
admet-2774	43	39	ε	ε	NOUN
admet-2774	43	40	-	-	PUNCT
admet-2774	43	41	caprolactone	caprolactone	ADJ
admet-2774	43	42	nanoparticles	nanoparticle	NOUN
admet-2774	43	43	doi	doi	NOUN
admet-2774	43	44	:	:	PUNCT
admet-2774	43	45	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	NOUN
admet-2774	43	46	3	3	NUM
admet-2774	43	47	therapeutic	therapeutic	ADJ
admet-2774	43	48	performance	performance	NOUN
admet-2774	43	49	.	.	PUNCT
admet-2774	44	1	this	this	DET
admet-2774	44	2	optimized	optimize	VERB
admet-2774	44	3	platform	platform	NOUN
admet-2774	44	4	could	could	AUX
admet-2774	44	5	pave	pave	VERB
admet-2774	44	6	the	the	DET
admet-2774	44	7	way	way	NOUN
admet-2774	44	8	for	for	ADP
admet-2774	44	9	scalable	scalable	ADJ
admet-2774	44	10	,	,	PUNCT
admet-2774	44	11	efficient	efficient	ADJ
admet-2774	44	12	tb	tb	ADP
admet-2774	44	13	treatment	treatment	NOUN
admet-2774	44	14	with	with	ADP
admet-2774	44	15	reduced	reduce	VERB
admet-2774	44	16	systemic	systemic	ADJ
admet-2774	44	17	side	side	NOUN
admet-2774	44	18	effects	effect	NOUN
admet-2774	44	19	.	.	PUNCT
admet-2774	45	1	comprehensive	comprehensive	ADJ
admet-2774	45	2	characterization	characterization	NOUN
admet-2774	45	3	confirmed	confirm	VERB
admet-2774	45	4	optimal	optimal	ADJ
admet-2774	45	5	nanoparticle	nanoparticle	NOUN
admet-2774	45	6	characteristics	characteristic	NOUN
admet-2774	45	7	(	(	PUNCT
admet-2774	45	8	size	size	NOUN
admet-2774	45	9	<	<	X
admet-2774	45	10	188	188	NUM
admet-2774	45	11	nm	nm	NOUN
admet-2774	45	12	,	,	PUNCT
admet-2774	45	13	pdi	pdi	PROPN
admet-2774	45	14	<	<	X
admet-2774	45	15	0.3	0.3	NUM
admet-2774	45	16	,	,	PUNCT
admet-2774	45	17	high	high	ADJ
admet-2774	45	18	ee	ee	PROPN
admet-2774	45	19	)	)	PUNCT
admet-2774	45	20	.	.	PUNCT
admet-2774	46	1	the	the	DET
admet-2774	46	2	lead	lead	ADJ
admet-2774	46	3	formulation	formulation	NOUN
admet-2774	46	4	achieved	achieve	VERB
admet-2774	46	5	sustained	sustain	VERB
admet-2774	46	6	inh	inh	PROPN
admet-2774	46	7	release	release	NOUN
admet-2774	46	8	,	,	PUNCT
admet-2774	46	9	addressing	address	VERB
admet-2774	46	10	key	key	ADJ
admet-2774	46	11	challenges	challenge	NOUN
admet-2774	46	12	in	in	ADP
admet-2774	46	13	tb	tb	ADP
admet-2774	46	14	treatment	treatment	NOUN
admet-2774	46	15	.	.	PUNCT
admet-2774	47	1	materials	material	NOUN
admet-2774	47	2	and	and	CCONJ
admet-2774	47	3	methods	method	NOUN
admet-2774	47	4	materials	material	NOUN
admet-2774	47	5	isoniazid	isoniazid	NOUN
admet-2774	47	6	(	(	PUNCT
admet-2774	47	7	inh	inh	PROPN
admet-2774	47	8	)	)	PUNCT
admet-2774	47	9	was	be	AUX
admet-2774	47	10	generously	generously	ADV
admet-2774	47	11	provided	provide	VERB
admet-2774	47	12	by	by	ADP
admet-2774	47	13	lupin	lupin	PROPN
admet-2774	47	14	ltd	ltd	PROPN
admet-2774	47	15	.	.	PROPN
admet-2774	48	1	(	(	PUNCT
admet-2774	48	2	chhatrapati	chhatrapati	NOUN
admet-2774	48	3	sambhajinagar	sambhajinagar	NOUN
admet-2774	48	4	,	,	PUNCT
admet-2774	48	5	india	india	PROPN
admet-2774	48	6	)	)	PUNCT
admet-2774	48	7	,	,	PUNCT
admet-2774	48	8	while	while	SCONJ
admet-2774	48	9	poly(εcaprolactone	poly(εcaprolactone	PROPN
admet-2774	48	10	)	)	PUNCT
admet-2774	48	11	(	(	PUNCT
admet-2774	48	12	pcl	pcl	PROPN
admet-2774	48	13	)	)	PUNCT
admet-2774	48	14	and	and	CCONJ
admet-2774	48	15	lactose	lactose	NOUN
admet-2774	48	16	were	be	AUX
admet-2774	48	17	obtained	obtain	VERB
admet-2774	48	18	from	from	ADP
admet-2774	48	19	sigma	sigma	PROPN
admet-2774	48	20	-	-	PUNCT
admet-2774	48	21	aldrich	aldrich	PROPN
admet-2774	48	22	(	(	PUNCT
admet-2774	48	23	usa	usa	PROPN
admet-2774	48	24	)	)	PUNCT
admet-2774	48	25	.	.	PUNCT
admet-2774	49	1	poloxamer	poloxamer	NOUN
admet-2774	49	2	188	188	NUM
admet-2774	49	3	(	(	PUNCT
admet-2774	49	4	p-188	p-188	VERB
admet-2774	49	5	)	)	PUNCT
admet-2774	49	6	was	be	AUX
admet-2774	49	7	purchased	purchase	VERB
admet-2774	49	8	from	from	ADP
admet-2774	49	9	basf	basf	PROPN
admet-2774	49	10	(	(	PUNCT
admet-2774	49	11	mumbai	mumbai	PROPN
admet-2774	49	12	,	,	PUNCT
admet-2774	49	13	india	india	PROPN
admet-2774	49	14	)	)	PUNCT
admet-2774	49	15	.	.	PUNCT
admet-2774	50	1	mannitol	mannitol	NOUN
admet-2774	50	2	was	be	AUX
admet-2774	50	3	obtained	obtain	VERB
admet-2774	50	4	from	from	ADP
admet-2774	50	5	hi	hi	ADJ
admet-2774	50	6	-	-	NOUN
admet-2774	50	7	media	medium	NOUN
admet-2774	50	8	,	,	PUNCT
admet-2774	50	9	mumbai	mumbai	PROPN
admet-2774	50	10	.	.	PUNCT
admet-2774	51	1	all	all	DET
admet-2774	51	2	solvents	solvent	NOUN
admet-2774	51	3	,	,	PUNCT
admet-2774	51	4	including	include	VERB
admet-2774	51	5	methanol	methanol	NOUN
admet-2774	51	6	,	,	PUNCT
admet-2774	51	7	acetone	acetone	NOUN
admet-2774	51	8	,	,	PUNCT
admet-2774	51	9	and	and	CCONJ
admet-2774	51	10	glacial	glacial	ADJ
admet-2774	51	11	acetic	acetic	ADJ
admet-2774	51	12	acid	acid	NOUN
admet-2774	51	13	,	,	PUNCT
admet-2774	51	14	along	along	ADP
admet-2774	51	15	with	with	ADP
admet-2774	51	16	sodium	sodium	NOUN
admet-2774	51	17	chloride	chloride	NOUN
admet-2774	51	18	,	,	PUNCT
admet-2774	51	19	potassium	potassium	NOUN
admet-2774	51	20	chloride	chloride	NOUN
admet-2774	51	21	,	,	PUNCT
admet-2774	51	22	hydrochloric	hydrochloric	ADJ
admet-2774	51	23	acid	acid	NOUN
admet-2774	51	24	,	,	PUNCT
admet-2774	51	25	and	and	CCONJ
admet-2774	51	26	sodium	sodium	NOUN
admet-2774	51	27	hydroxide	hydroxide	NOUN
admet-2774	51	28	,	,	PUNCT
admet-2774	51	29	were	be	AUX
admet-2774	51	30	procured	procure	VERB
admet-2774	51	31	from	from	ADP
admet-2774	51	32	sisco	sisco	PROPN
admet-2774	51	33	research	research	PROPN
admet-2774	51	34	laboratories	laboratory	NOUN
admet-2774	51	35	pvt	pvt	PROPN
admet-2774	51	36	.	.	PROPN
admet-2774	51	37	ltd	ltd	PROPN
admet-2774	51	38	.	.	PROPN
admet-2774	52	1	(	(	PUNCT
admet-2774	52	2	mumbai	mumbai	PROPN
admet-2774	52	3	,	,	PUNCT
admet-2774	52	4	india	india	PROPN
admet-2774	52	5	)	)	PUNCT
admet-2774	52	6	.	.	PUNCT
admet-2774	53	1	disodium	disodium	NOUN
admet-2774	53	2	hydrogen	hydrogen	NOUN
admet-2774	53	3	phosphate	phosphate	NOUN
admet-2774	53	4	,	,	PUNCT
admet-2774	53	5	potassium	potassium	NOUN
admet-2774	53	6	dihydrogen	dihydrogen	NOUN
admet-2774	53	7	phosphate	phosphate	NOUN
admet-2774	53	8	,	,	PUNCT
admet-2774	53	9	and	and	CCONJ
admet-2774	53	10	tween	tween	NOUN
admet-2774	53	11	80	80	NUM
admet-2774	53	12	were	be	AUX
admet-2774	53	13	purchased	purchase	VERB
admet-2774	53	14	from	from	ADP
admet-2774	53	15	merck	merck	PROPN
admet-2774	53	16	india	india	PROPN
admet-2774	53	17	.	.	PUNCT
admet-2774	54	1	all	all	DET
admet-2774	54	2	chemicals	chemical	NOUN
admet-2774	54	3	and	and	CCONJ
admet-2774	54	4	reagents	reagent	NOUN
admet-2774	54	5	used	use	VERB
admet-2774	54	6	are	be	AUX
admet-2774	54	7	of	of	ADP
admet-2774	54	8	analytical	analytical	ADJ
admet-2774	54	9	grade	grade	NOUN
admet-2774	54	10	purity	purity	NOUN
admet-2774	54	11	.	.	PUNCT
admet-2774	55	1	preparation	preparation	NOUN
admet-2774	55	2	of	of	ADP
admet-2774	55	3	nanoparticles	nanoparticle	NOUN
admet-2774	55	4	the	the	DET
admet-2774	55	5	inh	inh	NOUN
admet-2774	55	6	-	-	PUNCT
admet-2774	55	7	loaded	load	VERB
admet-2774	55	8	pcl	pcl	PROPN
admet-2774	55	9	nanoparticles	nanoparticle	NOUN
admet-2774	55	10	were	be	AUX
admet-2774	55	11	prepared	prepare	VERB
admet-2774	55	12	using	use	VERB
admet-2774	55	13	a	a	DET
admet-2774	55	14	microreactor	microreactor	NOUN
admet-2774	55	15	-	-	PUNCT
admet-2774	55	16	assisted	assist	VERB
admet-2774	55	17	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	55	18	technique	technique	NOUN
admet-2774	55	19	.	.	PUNCT
admet-2774	56	1	the	the	DET
admet-2774	56	2	fabrication	fabrication	NOUN
admet-2774	56	3	involved	involve	VERB
admet-2774	56	4	the	the	DET
admet-2774	56	5	following	follow	VERB
admet-2774	56	6	steps	step	NOUN
admet-2774	56	7	:	:	PUNCT
admet-2774	56	8	first	first	ADJ
admet-2774	56	9	,	,	PUNCT
admet-2774	56	10	100	100	NUM
admet-2774	56	11	mg	mg	PROPN
admet-2774	56	12	of	of	ADP
admet-2774	56	13	pcl	pcl	PROPN
admet-2774	56	14	was	be	AUX
admet-2774	56	15	dissolved	dissolve	VERB
admet-2774	56	16	in	in	ADP
admet-2774	56	17	acetone	acetone	NOUN
admet-2774	56	18	under	under	ADP
admet-2774	56	19	sonication	sonication	NOUN
admet-2774	56	20	for	for	ADP
admet-2774	56	21	15	15	NUM
admet-2774	56	22	minutes	minute	NOUN
admet-2774	56	23	(	(	PUNCT
admet-2774	56	24	designated	designate	VERB
admet-2774	56	25	organic	organic	ADJ
admet-2774	56	26	phase	phase	NOUN
admet-2774	56	27	-	-	PUNCT
admet-2774	56	28	solution	solution	NOUN
admet-2774	56	29	a	a	PRON
admet-2774	56	30	)	)	PUNCT
admet-2774	56	31	,	,	PUNCT
admet-2774	56	32	and	and	CCONJ
admet-2774	56	33	tween	tween	NOUN
admet-2774	56	34	80	80	NUM
admet-2774	56	35	was	be	AUX
admet-2774	56	36	used	use	VERB
admet-2774	56	37	as	as	ADP
admet-2774	56	38	a	a	DET
admet-2774	56	39	stabilizer	stabilizer	NOUN
admet-2774	56	40	.	.	PUNCT
admet-2774	57	1	simultaneously	simultaneously	ADV
admet-2774	57	2	,	,	PUNCT
admet-2774	57	3	an	an	DET
admet-2774	57	4	aqueous	aqueous	ADJ
admet-2774	57	5	phase	phase	NOUN
admet-2774	57	6	(	(	PUNCT
admet-2774	57	7	solution	solution	NOUN
admet-2774	57	8	b	b	NOUN
admet-2774	57	9	)	)	PUNCT
admet-2774	57	10	containing	contain	VERB
admet-2774	57	11	0.1	0.1	NUM
admet-2774	57	12	wt.%	wt.%	PROPN
admet-2774	57	13	poloxamer	poloxamer	NOUN
admet-2774	57	14	188	188	NUM
admet-2774	57	15	(	(	PUNCT
admet-2774	57	16	copolymer	copolymer	NOUN
admet-2774	57	17	;	;	PUNCT
admet-2774	57	18	surfactant	surfactant	NOUN
admet-2774	57	19	)	)	PUNCT
admet-2774	57	20	was	be	AUX
admet-2774	57	21	prepared	prepare	VERB
admet-2774	57	22	.	.	PUNCT
admet-2774	58	1	separately	separately	ADV
admet-2774	58	2	,	,	PUNCT
admet-2774	58	3	50	50	NUM
admet-2774	58	4	mg	mg	NOUN
admet-2774	58	5	of	of	ADP
admet-2774	58	6	inh	inh	PROPN
admet-2774	58	7	was	be	AUX
admet-2774	58	8	dissolved	dissolve	VERB
admet-2774	58	9	in	in	ADP
admet-2774	58	10	5	5	NUM
admet-2774	58	11	ml	ml	NOUN
admet-2774	58	12	of	of	ADP
admet-2774	58	13	double	double	ADJ
admet-2774	58	14	-	-	PUNCT
admet-2774	58	15	distilled	distil	VERB
admet-2774	58	16	water	water	NOUN
admet-2774	58	17	and	and	CCONJ
admet-2774	58	18	subsequently	subsequently	ADV
admet-2774	58	19	added	add	VERB
admet-2774	58	20	to	to	ADP
admet-2774	58	21	solution	solution	NOUN
admet-2774	58	22	b	b	NOUN
admet-2774	58	23	dropwise	dropwise	NOUN
admet-2774	58	24	using	use	VERB
admet-2774	58	25	a	a	DET
admet-2774	58	26	syringe	syringe	NOUN
admet-2774	58	27	.	.	PUNCT
admet-2774	59	1	solutions	solution	NOUN
admet-2774	59	2	a	a	DET
admet-2774	59	3	(	(	PUNCT
admet-2774	59	4	organic	organic	ADJ
admet-2774	59	5	phase	phase	NOUN
admet-2774	59	6	)	)	PUNCT
admet-2774	59	7	and	and	CCONJ
admet-2774	59	8	b	b	X
admet-2774	59	9	(	(	PUNCT
admet-2774	59	10	aqueous	aqueous	ADJ
admet-2774	59	11	phase	phase	NOUN
admet-2774	59	12	)	)	PUNCT
admet-2774	59	13	were	be	AUX
admet-2774	59	14	each	each	PRON
admet-2774	59	15	stirred	stir	VERB
admet-2774	59	16	separately	separately	ADV
admet-2774	59	17	under	under	ADP
admet-2774	59	18	constant	constant	ADJ
admet-2774	59	19	magnetic	magnetic	ADJ
admet-2774	59	20	agitation	agitation	NOUN
admet-2774	59	21	(	(	PUNCT
admet-2774	59	22	600	600	NUM
admet-2774	59	23	rpm	rpm	NOUN
admet-2774	59	24	,	,	PUNCT
admet-2774	59	25	30	30	NUM
admet-2774	59	26	min	min	NOUN
admet-2774	59	27	)	)	PUNCT
admet-2774	59	28	and	and	CCONJ
admet-2774	59	29	then	then	ADV
admet-2774	59	30	filtered	filter	VERB
admet-2774	59	31	through	through	ADP
admet-2774	59	32	a	a	DET
admet-2774	59	33	0.45	0.45	NUM
admet-2774	59	34	µm	µm	ADP
admet-2774	59	35	pvdf	pvdf	PROPN
admet-2774	59	36	membrane	membrane	NOUN
admet-2774	59	37	(	(	PUNCT
admet-2774	59	38	bsb	bsb	PROPN
admet-2774	59	39	pharma	pharma	PROPN
admet-2774	59	40	,	,	PUNCT
admet-2774	59	41	thane	thane	NOUN
admet-2774	59	42	)	)	PUNCT
admet-2774	59	43	for	for	ADP
admet-2774	59	44	further	further	ADJ
admet-2774	59	45	use	use	NOUN
admet-2774	59	46	.	.	PUNCT
admet-2774	60	1	the	the	DET
admet-2774	60	2	filtered	filter	VERB
admet-2774	60	3	solutions	solution	NOUN
admet-2774	60	4	were	be	AUX
admet-2774	60	5	subsequently	subsequently	ADV
admet-2774	60	6	processed	process	VERB
admet-2774	60	7	through	through	ADP
admet-2774	60	8	a	a	DET
admet-2774	60	9	microreactor	microreactor	NOUN
admet-2774	60	10	system	system	NOUN
admet-2774	60	11	(	(	PUNCT
admet-2774	60	12	amar	amar	PROPN
admet-2774	60	13	ii	ii	PROPN
admet-2774	60	14	,	,	PUNCT
admet-2774	60	15	equipment	equipment	NOUN
admet-2774	60	16	,	,	PUNCT
admet-2774	60	17	mumbai	mumbai	PROPN
admet-2774	60	18	)	)	PUNCT
admet-2774	60	19	connected	connect	VERB
admet-2774	60	20	to	to	ADP
admet-2774	60	21	an	an	DET
admet-2774	60	22	infusion	infusion	NOUN
admet-2774	60	23	pump	pump	NOUN
admet-2774	60	24	(	(	PUNCT
admet-2774	60	25	uni	uni	PROPN
admet-2774	60	26	labs	labs	PROPN
admet-2774	60	27	)	)	PUNCT
admet-2774	60	28	,	,	PUNCT
admet-2774	60	29	maintaining	maintain	VERB
admet-2774	60	30	a	a	DET
admet-2774	60	31	constant	constant	ADJ
admet-2774	60	32	flow	flow	NOUN
admet-2774	60	33	rate	rate	NOUN
admet-2774	60	34	of	of	ADP
admet-2774	60	35	0.24	0.24	NUM
admet-2774	60	36	ml	ml	NOUN
admet-2774	60	37	/	/	SYM
admet-2774	60	38	min	min	NOUN
admet-2774	60	39	.	.	PUNCT
admet-2774	61	1	the	the	DET
admet-2774	61	2	resulting	result	VERB
admet-2774	61	3	nanosuspension	nanosuspension	NOUN
admet-2774	61	4	was	be	AUX
admet-2774	61	5	collected	collect	VERB
admet-2774	61	6	from	from	ADP
admet-2774	61	7	the	the	DET
admet-2774	61	8	microreactor	microreactor	NOUN
admet-2774	61	9	outlet	outlet	NOUN
admet-2774	61	10	under	under	ADP
admet-2774	61	11	continuous	continuous	ADJ
admet-2774	61	12	stirring	stirring	NOUN
admet-2774	61	13	(	(	PUNCT
admet-2774	61	14	400	400	NUM
admet-2774	61	15	rpm	rpm	NOUN
admet-2774	61	16	)	)	PUNCT
admet-2774	61	17	at	at	ADP
admet-2774	61	18	ambient	ambient	ADJ
admet-2774	61	19	temperature	temperature	NOUN
admet-2774	61	20	[	[	X
admet-2774	61	21	27,28	27,28	NOUN
admet-2774	61	22	]	]	X
admet-2774	61	23	.	.	PUNCT
admet-2774	62	1	the	the	DET
admet-2774	62	2	inhencapsulated	inhencapsulate	VERB
admet-2774	62	3	nanoparticles	nanoparticle	NOUN
admet-2774	62	4	were	be	AUX
admet-2774	62	5	purified	purify	VERB
admet-2774	62	6	by	by	ADP
admet-2774	62	7	three	three	NUM
admet-2774	62	8	cycles	cycle	NOUN
admet-2774	62	9	of	of	ADP
admet-2774	62	10	centrifugation	centrifugation	NOUN
admet-2774	62	11	(	(	PUNCT
admet-2774	62	12	10,000	10,000	NUM
admet-2774	62	13	rpm	rpm	NOUN
admet-2774	62	14	,	,	PUNCT
admet-2774	62	15	60	60	NUM
admet-2774	62	16	min	min	NOUN
admet-2774	62	17	,	,	PUNCT
admet-2774	62	18	4	4	NUM
admet-2774	62	19	°	°	NOUN
admet-2774	62	20	c	c	NOUN
admet-2774	62	21	)	)	PUNCT
admet-2774	62	22	.	.	PUNCT
admet-2774	63	1	as	as	ADP
admet-2774	63	2	a	a	DET
admet-2774	63	3	control	control	NOUN
admet-2774	63	4	,	,	PUNCT
admet-2774	63	5	blank	blank	PROPN
admet-2774	63	6	pcl	pcl	PROPN
admet-2774	63	7	nanoparticles	nanoparticle	NOUN
admet-2774	63	8	were	be	AUX
admet-2774	63	9	prepared	prepare	VERB
admet-2774	63	10	following	follow	VERB
admet-2774	63	11	the	the	DET
admet-2774	63	12	identical	identical	ADJ
admet-2774	63	13	protocol	protocol	NOUN
admet-2774	63	14	without	without	ADP
admet-2774	63	15	drug	drug	NOUN
admet-2774	63	16	incorporation	incorporation	NOUN
admet-2774	63	17	.	.	PUNCT
admet-2774	64	1	the	the	DET
admet-2774	64	2	resuspended	resuspend	VERB
admet-2774	64	3	inh	inh	NOUN
admet-2774	64	4	-	-	PUNCT
admet-2774	64	5	loaded	load	VERB
admet-2774	64	6	pcl	pcl	PROPN
admet-2774	64	7	nanoparticle	nanoparticle	NOUN
admet-2774	64	8	formulation	formulation	NOUN
admet-2774	64	9	underwent	underwent	NOUN
admet-2774	64	10	pre	pre	ADJ
admet-2774	64	11	-	-	ADJ
admet-2774	64	12	freezing	freezing	ADJ
admet-2774	64	13	at	at	ADP
admet-2774	64	14	-20	-20	NUM
admet-2774	64	15	°	°	PROPN
admet-2774	64	16	c	c	NOUN
admet-2774	64	17	for	for	ADP
admet-2774	64	18	12	12	NUM
admet-2774	64	19	h	h	NOUN
admet-2774	64	20	before	before	ADP
admet-2774	64	21	lyophilization	lyophilization	NOUN
admet-2774	64	22	in	in	ADP
admet-2774	64	23	a	a	DET
admet-2774	64	24	vacuum	vacuum	NOUN
admet-2774	64	25	freeze	freeze	NOUN
admet-2774	64	26	-	-	PUNCT
admet-2774	64	27	dryer	dryer	NOUN
admet-2774	64	28	(	(	PUNCT
admet-2774	64	29	boyikang	boyikang	NOUN
admet-2774	64	30	laboratory	laboratory	PROPN
admet-2774	64	31	instruments	instruments	PROPN
admet-2774	64	32	inc	inc	PROPN
admet-2774	64	33	.	.	PROPN
admet-2774	64	34	,	,	PUNCT
admet-2774	64	35	china	china	PROPN
admet-2774	64	36	)	)	PUNCT
admet-2774	64	37	over	over	ADP
admet-2774	64	38	a	a	DET
admet-2774	64	39	48	48	NUM
admet-2774	64	40	h	h	NOUN
admet-2774	64	41	cycle	cycle	NOUN
admet-2774	64	42	and	and	CCONJ
admet-2774	64	43	during	during	ADP
admet-2774	64	44	the	the	DET
admet-2774	64	45	lyophilization	lyophilization	NOUN
admet-2774	64	46	,	,	PUNCT
admet-2774	64	47	mannitol	mannitol	NOUN
admet-2774	64	48	was	be	AUX
admet-2774	64	49	added	add	VERB
admet-2774	64	50	as	as	ADP
admet-2774	64	51	cryoprotectant	cryoprotectant	NOUN
admet-2774	64	52	.	.	PUNCT
admet-2774	65	1	the	the	DET
admet-2774	65	2	lyophilized	lyophilized	ADJ
admet-2774	65	3	nanoparticles	nanoparticle	NOUN
admet-2774	65	4	were	be	AUX
admet-2774	65	5	collected	collect	VERB
admet-2774	65	6	as	as	ADP
admet-2774	65	7	a	a	DET
admet-2774	65	8	free	free	ADV
admet-2774	65	9	-	-	PUNCT
admet-2774	65	10	flowing	flow	VERB
admet-2774	65	11	powder	powder	NOUN
admet-2774	65	12	,	,	PUNCT
admet-2774	65	13	transferred	transfer	VERB
admet-2774	65	14	to	to	ADP
admet-2774	65	15	amber	amber	PROPN
admet-2774	65	16	glass	glass	PROPN
admet-2774	65	17	vials	vial	NOUN
admet-2774	65	18	,	,	PUNCT
admet-2774	65	19	and	and	CCONJ
admet-2774	65	20	stored	store	VERB
admet-2774	65	21	in	in	ADP
admet-2774	65	22	a	a	DET
admet-2774	65	23	desiccator	desiccator	NOUN
admet-2774	65	24	containing	contain	VERB
admet-2774	65	25	anhydrous	anhydrous	ADJ
admet-2774	65	26	silica	silica	NOUN
admet-2774	65	27	gel	gel	NOUN
admet-2774	65	28	at	at	ADP
admet-2774	65	29	25	25	NUM
admet-2774	65	30	±	±	NUM
admet-2774	65	31	2	2	NUM
admet-2774	65	32	°	°	ADP
admet-2774	65	33	c	c	NOUN
admet-2774	65	34	until	until	ADP
admet-2774	65	35	subsequent	subsequent	ADJ
admet-2774	65	36	characterization	characterization	NOUN
admet-2774	65	37	studies	study	NOUN
admet-2774	65	38	.	.	PUNCT
admet-2774	66	1	experimental	experimental	ADJ
admet-2774	66	2	design	design	VERB
admet-2774	66	3	the	the	DET
admet-2774	66	4	optimization	optimization	NOUN
admet-2774	66	5	of	of	ADP
admet-2774	66	6	inh	inh	PROPN
admet-2774	66	7	-	-	PUNCT
admet-2774	66	8	loaded	load	VERB
admet-2774	66	9	pcl	pcl	PROPN
admet-2774	66	10	nanoparticles	nanoparticle	NOUN
admet-2774	66	11	or	or	CCONJ
admet-2774	66	12	nanoformulation	nanoformulation	NOUN
admet-2774	66	13	was	be	AUX
admet-2774	66	14	investigated	investigate	VERB
admet-2774	66	15	using	use	VERB
admet-2774	66	16	a	a	DET
admet-2774	66	17	boxbehnken	boxbehnken	VERB
admet-2774	66	18	experimental	experimental	ADJ
admet-2774	66	19	design	design	NOUN
admet-2774	66	20	,	,	PUNCT
admet-2774	66	21	and	and	CCONJ
admet-2774	66	22	three	three	NUM
admet-2774	66	23	independent	independent	ADJ
admet-2774	66	24	variables	variable	NOUN
admet-2774	66	25	were	be	AUX
admet-2774	66	26	evaluated	evaluate	VERB
admet-2774	66	27	at	at	ADP
admet-2774	66	28	three	three	NUM
admet-2774	66	29	levels	level	NOUN
admet-2774	66	30	[	[	X
admet-2774	66	31	29	29	NUM
admet-2774	66	32	]	]	PUNCT
admet-2774	66	33	.	.	PUNCT
admet-2774	67	1	based	base	VERB
admet-2774	67	2	on	on	ADP
admet-2774	67	3	preliminary	preliminary	ADJ
admet-2774	67	4	screening	screening	NOUN
admet-2774	67	5	studies	study	NOUN
admet-2774	67	6	,	,	PUNCT
admet-2774	67	7	two	two	NUM
admet-2774	67	8	polymer	polymer	NOUN
admet-2774	67	9	concentration	concentration	NOUN
admet-2774	67	10	parameters	parameter	NOUN
admet-2774	67	11	(	(	PUNCT
admet-2774	67	12	x1	x1	PROPN
admet-2774	67	13	,	,	PUNCT
admet-2774	67	14	x2	x2	PROPN
admet-2774	67	15	)	)	PUNCT
admet-2774	67	16	and	and	CCONJ
admet-2774	67	17	stabilizer	stabilizer	NOUN
admet-2774	67	18	content	content	NOUN
admet-2774	67	19	(	(	PUNCT
admet-2774	67	20	x3	x3	ADJ
admet-2774	67	21	)	)	PUNCT
admet-2774	67	22	were	be	AUX
admet-2774	67	23	chosen	choose	VERB
admet-2774	67	24	as	as	ADP
admet-2774	67	25	critical	critical	ADJ
admet-2774	67	26	formulation	formulation	NOUN
admet-2774	67	27	factors	factor	NOUN
admet-2774	67	28	.	.	PUNCT
admet-2774	68	1	we	we	PRON
admet-2774	68	2	examined	examine	VERB
admet-2774	68	3	three	three	NUM
admet-2774	68	4	levels	level	NOUN
admet-2774	68	5	for	for	ADP
admet-2774	68	6	the	the	DET
admet-2774	68	7	independent	independent	ADJ
admet-2774	68	8	variables	variable	NOUN
admet-2774	68	9	:	:	PUNCT
admet-2774	68	10	low	low	ADJ
admet-2774	68	11	,	,	PUNCT
admet-2774	68	12	medium	medium	ADJ
admet-2774	68	13	and	and	CCONJ
admet-2774	68	14	high	high	ADJ
admet-2774	68	15	,	,	PUNCT
admet-2774	68	16	as	as	SCONJ
admet-2774	68	17	outlined	outline	VERB
admet-2774	68	18	in	in	ADP
admet-2774	68	19	table	table	NOUN
admet-2774	68	20	1	1	NUM
admet-2774	68	21	.	.	PUNCT
admet-2774	69	1	these	these	DET
admet-2774	69	2	variables	variable	NOUN
admet-2774	69	3	were	be	AUX
admet-2774	69	4	examined	examine	VERB
admet-2774	69	5	for	for	ADP
admet-2774	69	6	their	their	PRON
admet-2774	69	7	effects	effect	NOUN
admet-2774	69	8	on	on	ADP
admet-2774	69	9	three	three	NUM
admet-2774	69	10	key	key	ADJ
admet-2774	69	11	nanoparticle	nanoparticle	NOUN
admet-2774	69	12	characteristics	characteristic	NOUN
admet-2774	69	13	:	:	PUNCT
admet-2774	69	14	average	average	ADJ
admet-2774	69	15	particle	particle	NOUN
admet-2774	69	16	size	size	NOUN
admet-2774	69	17	(	(	PUNCT
admet-2774	69	18	y1	y1	NOUN
admet-2774	69	19	)	)	PUNCT
admet-2774	69	20	,	,	PUNCT
admet-2774	69	21	pdi	pdi	PROPN
admet-2774	69	22	(	(	PUNCT
admet-2774	69	23	y2	y2	PROPN
admet-2774	69	24	)	)	PUNCT
admet-2774	69	25	,	,	PUNCT
admet-2774	69	26	and	and	CCONJ
admet-2774	69	27	surface	surface	NOUN
admet-2774	69	28	charge	charge	NOUN
admet-2774	69	29	(	(	PUNCT
admet-2774	69	30	y3	y3	PROPN
admet-2774	69	31	)	)	PUNCT
admet-2774	69	32	.	.	PUNCT
admet-2774	70	1	the	the	DET
admet-2774	70	2	fabricated	fabricate	VERB
admet-2774	70	3	inh	inh	NOUN
admet-2774	70	4	-	-	PUNCT
admet-2774	70	5	loaded	load	VERB
admet-2774	70	6	pcl	pcl	PROPN
admet-2774	70	7	nanoparticles	nanoparticle	NOUN
admet-2774	70	8	were	be	AUX
admet-2774	70	9	considered	consider	VERB
admet-2774	70	10	concerning	concern	VERB
admet-2774	70	11	critical	critical	ADJ
admet-2774	70	12	variables	variable	NOUN
admet-2774	70	13	,	,	PUNCT
admet-2774	70	14	including	include	VERB
admet-2774	70	15	particle	particle	NOUN
admet-2774	70	16	size	size	NOUN
admet-2774	70	17	,	,	PUNCT
admet-2774	70	18	pdi	pdi	NOUN
admet-2774	70	19	,	,	PUNCT
admet-2774	70	20	and	and	CCONJ
admet-2774	70	21	surface	surface	NOUN
admet-2774	70	22	charge	charge	NOUN
admet-2774	70	23	.	.	PUNCT
admet-2774	71	1	the	the	DET
admet-2774	71	2	experimental	experimental	ADJ
admet-2774	71	3	run	run	NOUN
admet-2774	71	4	,	,	PUNCT
admet-2774	71	5	consisting	consist	VERB
admet-2774	71	6	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	PROPN
admet-2774	71	7	e.	e.	PROPN
admet-2774	71	8	kole	kole	PROPN
admet-2774	71	9	et	et	PROPN
admet-2774	71	10	al	al	PROPN
admet-2774	71	11	.	.	PROPN
admet-2774	71	12	admet	admet	PROPN
admet-2774	71	13	&	&	CCONJ
admet-2774	71	14	dmpk	dmpk	PROPN
admet-2774	71	15	13(4	13(4	NUM
admet-2774	71	16	)	)	PUNCT
admet-2774	71	17	(	(	PUNCT
admet-2774	71	18	2025	2025	NUM
admet-2774	71	19	)	)	PUNCT
admet-2774	71	20	2774	2774	NUM
admet-2774	71	21	4	4	NUM
admet-2774	71	22	of	of	ADP
admet-2774	71	23	17	17	NUM
admet-2774	71	24	randomized	randomized	ADJ
admet-2774	71	25	test	test	NOUN
admet-2774	71	26	conditions	condition	NOUN
admet-2774	71	27	with	with	ADP
admet-2774	71	28	triplicate	triplicate	NOUN
admet-2774	71	29	runs	run	NOUN
admet-2774	71	30	,	,	PUNCT
admet-2774	71	31	was	be	AUX
admet-2774	71	32	generated	generate	VERB
admet-2774	71	33	using	use	VERB
admet-2774	71	34	design	design	NOUN
admet-2774	71	35	expert	expert	NOUN
admet-2774	71	36	®	®	NOUN
admet-2774	71	37	software	software	NOUN
admet-2774	71	38	,	,	PUNCT
admet-2774	71	39	(	(	PUNCT
admet-2774	71	40	statease	statease	PROPN
admet-2774	71	41	inc	inc	PROPN
admet-2774	71	42	.	.	PROPN
admet-2774	71	43	,	,	PUNCT
admet-2774	71	44	usa	usa	PROPN
admet-2774	71	45	,	,	PUNCT
admet-2774	71	46	https://www.statease.com/software/design-expert/	https://www.statease.com/software/design-expert/	CCONJ
admet-2774	71	47	)	)	PUNCT
admet-2774	71	48	(	(	PUNCT
admet-2774	71	49	table	table	NOUN
admet-2774	71	50	2	2	NUM
admet-2774	71	51	)	)	PUNCT
admet-2774	71	52	.	.	PUNCT
admet-2774	72	1	table	table	NOUN
admet-2774	72	2	1	1	NUM
admet-2774	72	3	.	.	PUNCT
admet-2774	72	4	experimental	experimental	ADJ
admet-2774	72	5	design	design	NOUN
admet-2774	72	6	framework	framework	NOUN
admet-2774	72	7	for	for	ADP
admet-2774	72	8	nanoparticle	nanoparticle	NOUN
admet-2774	72	9	optimization	optimization	NOUN
admet-2774	72	10	:	:	PUNCT
admet-2774	72	11	independent	independent	ADJ
admet-2774	72	12	variables	variable	NOUN
admet-2774	72	13	(	(	PUNCT
admet-2774	72	14	factors	factor	NOUN
admet-2774	72	15	)	)	PUNCT
admet-2774	72	16	with	with	ADP
admet-2774	72	17	operational	operational	ADJ
admet-2774	72	18	ranges	range	NOUN
admet-2774	72	19	and	and	CCONJ
admet-2774	72	20	dependent	dependent	ADJ
admet-2774	72	21	variables	variable	NOUN
admet-2774	72	22	(	(	PUNCT
admet-2774	72	23	responses	response	NOUN
admet-2774	72	24	)	)	PUNCT
admet-2774	72	25	with	with	ADP
admet-2774	72	26	constraints	constraint	NOUN
admet-2774	72	27	in	in	ADP
admet-2774	72	28	the	the	DET
admet-2774	72	29	box	box	NOUN
admet-2774	72	30	-	-	PUNCT
admet-2774	72	31	behnken	behnken	VERB
admet-2774	72	32	response	response	NOUN
admet-2774	72	33	surface	surface	NOUN
admet-2774	72	34	methodology	methodology	NOUN
admet-2774	72	35	(	(	PUNCT
admet-2774	72	36	rsm	rsm	NOUN
admet-2774	72	37	)	)	PUNCT
admet-2774	72	38	input	input	NOUN
admet-2774	72	39	variables	variable	NOUN
admet-2774	72	40	(	(	PUNCT
admet-2774	72	41	independent	independent	ADJ
admet-2774	72	42	variables	variable	NOUN
admet-2774	72	43	)	)	PUNCT
admet-2774	72	44	levels	level	NOUN
admet-2774	72	45	low	low	ADJ
admet-2774	72	46	(	(	PUNCT
admet-2774	72	47	-1	-1	NOUN
admet-2774	72	48	)	)	PUNCT
admet-2774	72	49	medium	medium	NOUN
admet-2774	72	50	(	(	PUNCT
admet-2774	72	51	0	0	NUM
admet-2774	72	52	)	)	PUNCT
admet-2774	72	53	high	high	ADJ
admet-2774	72	54	(	(	PUNCT
admet-2774	72	55	+1	+1	NOUN
admet-2774	72	56	)	)	PUNCT
admet-2774	72	57	numeric	numeric	ADJ
admet-2774	72	58	factors	factor	NOUN
admet-2774	72	59	x1	x1	ADJ
admet-2774	72	60	:	:	PUNCT
admet-2774	72	61	amount	amount	NOUN
admet-2774	72	62	of	of	ADP
admet-2774	72	63	pcl	pcl	PROPN
admet-2774	72	64	,	,	PUNCT
admet-2774	72	65	mg	mg	PROPN
admet-2774	72	66	6.5	6.5	NUM
admet-2774	72	67	13	13	NUM
admet-2774	72	68	52	52	NUM
admet-2774	72	69	x2	x2	NOUN
admet-2774	72	70	:	:	PUNCT
admet-2774	72	71	amount	amount	NOUN
admet-2774	72	72	of	of	ADP
admet-2774	72	73	poloxamer	poloxamer	NOUN
admet-2774	72	74	188	188	NUM
admet-2774	72	75	,	,	PUNCT
admet-2774	72	76	mg	mg	PROPN
admet-2774	72	77	5	5	NUM
admet-2774	72	78	10	10	NUM
admet-2774	72	79	20	20	NUM
admet-2774	72	80	x3	x3	ADJ
admet-2774	72	81	:	:	PUNCT
admet-2774	72	82	amount	amount	NOUN
admet-2774	72	83	of	of	ADP
admet-2774	72	84	tween	tween	NOUN
admet-2774	72	85	80	80	NUM
admet-2774	72	86	,	,	PUNCT
admet-2774	72	87	%	%	NOUN
admet-2774	72	88	w	w	NOUN
admet-2774	72	89	/	/	SYM
admet-2774	72	90	v	v	NOUN
admet-2774	72	91	(	(	PUNCT
admet-2774	72	92	stabilizer	stabilizer	NOUN
admet-2774	72	93	)	)	PUNCT
admet-2774	72	94	0.1	0.1	NUM
admet-2774	72	95	0.2	0.2	NUM
admet-2774	72	96	0.5	0.5	NUM
admet-2774	72	97	responses	response	NOUN
admet-2774	72	98	(	(	PUNCT
admet-2774	72	99	dependent	dependent	ADJ
admet-2774	72	100	variables	variable	NOUN
admet-2774	72	101	)	)	PUNCT
admet-2774	72	102	constraints	constraint	NOUN
admet-2774	72	103	y1	y1	NOUN
admet-2774	72	104	:	:	PUNCT
admet-2774	72	105	particle	particle	NOUN
admet-2774	72	106	size	size	NOUN
admet-2774	72	107	,	,	PUNCT
admet-2774	72	108	nm	nm	PRON
admet-2774	72	109	minimum	minimum	NOUN
admet-2774	72	110	y2	y2	NOUN
admet-2774	72	111	:	:	PUNCT
admet-2774	72	112	polydispersity	polydispersity	NOUN
admet-2774	72	113	index	index	NOUN
admet-2774	72	114	minimum	minimum	NOUN
admet-2774	72	115	y3	y3	PROPN
admet-2774	72	116	:	:	PUNCT
admet-2774	72	117	zeta	zeta	NOUN
admet-2774	72	118	potential	potential	NOUN
admet-2774	72	119	,	,	PUNCT
admet-2774	72	120	mv	mv	PROPN
admet-2774	72	121	±	±	NUM
admet-2774	72	122	less	less	ADJ
admet-2774	72	123	than	than	ADP
admet-2774	72	124	30	30	NUM
admet-2774	72	125	the	the	DET
admet-2774	72	126	polynomial	polynomial	ADJ
admet-2774	72	127	equations	equation	NOUN
admet-2774	72	128	representing	represent	VERB
admet-2774	72	129	the	the	DET
admet-2774	72	130	main	main	ADJ
admet-2774	72	131	effects	effect	NOUN
admet-2774	72	132	,	,	PUNCT
admet-2774	72	133	interaction	interaction	NOUN
admet-2774	72	134	,	,	PUNCT
admet-2774	72	135	and	and	CCONJ
admet-2774	72	136	linear	linear	PROPN
admet-2774	72	137	and	and	CCONJ
admet-2774	72	138	two	two	NUM
admet-2774	72	139	-	-	PUNCT
admet-2774	72	140	factor	factor	NOUN
admet-2774	72	141	interaction	interaction	NOUN
admet-2774	72	142	(	(	PUNCT
admet-2774	72	143	2fi	2fi	ADJ
admet-2774	72	144	)	)	PUNCT
admet-2774	72	145	effects	effect	NOUN
admet-2774	72	146	of	of	ADP
admet-2774	72	147	the	the	DET
admet-2774	72	148	independent	independent	ADJ
admet-2774	72	149	formulation	formulation	NOUN
admet-2774	72	150	variables	variable	NOUN
admet-2774	72	151	demonstrated	demonstrate	VERB
admet-2774	72	152	significant	significant	ADJ
admet-2774	72	153	impacts	impact	NOUN
admet-2774	72	154	on	on	ADP
admet-2774	72	155	the	the	DET
admet-2774	72	156	measured	measure	VERB
admet-2774	72	157	responses	response	NOUN
admet-2774	72	158	.	.	PUNCT
admet-2774	73	1	additionally	additionally	ADV
admet-2774	73	2	,	,	PUNCT
admet-2774	73	3	3d	3d	NUM
admet-2774	73	4	surfaces	surface	NOUN
admet-2774	73	5	and	and	CCONJ
admet-2774	73	6	contour	contour	NOUN
admet-2774	73	7	plots	plot	NOUN
admet-2774	73	8	were	be	AUX
admet-2774	73	9	used	use	VERB
admet-2774	73	10	to	to	PART
admet-2774	73	11	visually	visually	ADV
admet-2774	73	12	illustrate	illustrate	VERB
admet-2774	73	13	the	the	DET
admet-2774	73	14	effects	effect	NOUN
admet-2774	73	15	of	of	ADP
admet-2774	73	16	the	the	DET
admet-2774	73	17	independent	independent	ADJ
admet-2774	73	18	variables	variable	NOUN
admet-2774	73	19	on	on	ADP
admet-2774	73	20	the	the	DET
admet-2774	73	21	dependent	dependent	ADJ
admet-2774	73	22	responses	response	NOUN
admet-2774	73	23	.	.	PUNCT
admet-2774	74	1	this	this	DET
admet-2774	74	2	methodology	methodology	NOUN
admet-2774	74	3	follows	follow	VERB
admet-2774	74	4	modern	modern	ADJ
admet-2774	74	5	quality	quality	NOUN
admet-2774	74	6	-	-	PUNCT
admet-2774	74	7	focused	focus	VERB
admet-2774	74	8	development	development	NOUN
admet-2774	74	9	approaches	approach	NOUN
admet-2774	74	10	in	in	ADP
admet-2774	74	11	nanoparticle	nanoparticle	NOUN
admet-2774	74	12	formulation	formulation	NOUN
admet-2774	74	13	,	,	PUNCT
admet-2774	74	14	allowing	allow	VERB
admet-2774	74	15	efficient	efficient	ADJ
admet-2774	74	16	optimization	optimization	NOUN
admet-2774	74	17	with	with	ADP
admet-2774	74	18	minimal	minimal	ADJ
admet-2774	74	19	experimental	experimental	ADJ
admet-2774	74	20	runs	run	NOUN
admet-2774	74	21	while	while	SCONJ
admet-2774	74	22	ensuring	ensure	VERB
admet-2774	74	23	reliable	reliable	ADJ
admet-2774	74	24	reproducibility	reproducibility	NOUN
admet-2774	74	25	.	.	PUNCT
admet-2774	75	1	recent	recent	ADJ
admet-2774	75	2	nanocarrier	nanocarrier	PROPN
admet-2774	75	3	development	development	NOUN
admet-2774	75	4	studies	study	NOUN
admet-2774	75	5	have	have	AUX
admet-2774	75	6	shown	show	VERB
admet-2774	75	7	that	that	SCONJ
admet-2774	75	8	the	the	DET
admet-2774	75	9	selected	select	VERB
admet-2774	75	10	experimental	experimental	ADJ
admet-2774	75	11	design	design	NOUN
admet-2774	75	12	has	have	AUX
admet-2774	75	13	proven	prove	VERB
admet-2774	75	14	particularly	particularly	ADV
admet-2774	75	15	effective	effective	ADJ
admet-2774	75	16	for	for	ADP
admet-2774	75	17	pharmaceutical	pharmaceutical	ADJ
admet-2774	75	18	process	process	NOUN
admet-2774	75	19	optimization	optimization	NOUN
admet-2774	75	20	[	[	X
admet-2774	75	21	30	30	NUM
admet-2774	75	22	-	-	SYM
admet-2774	75	23	32	32	NUM
admet-2774	75	24	]	]	PUNCT
admet-2774	75	25	.	.	PUNCT
admet-2774	76	1	table	table	NOUN
admet-2774	76	2	2	2	NUM
admet-2774	76	3	.	.	PUNCT
admet-2774	76	4	response	response	NOUN
admet-2774	76	5	surface	surface	NOUN
admet-2774	76	6	methodology	methodology	NOUN
admet-2774	76	7	(	(	PUNCT
admet-2774	76	8	rsm	rsm	NOUN
admet-2774	76	9	)	)	PUNCT
admet-2774	76	10	outcomes	outcome	NOUN
admet-2774	76	11	for	for	ADP
admet-2774	76	12	inh	inh	NOUN
admet-2774	76	13	-	-	PUNCT
admet-2774	76	14	loaded	load	VERB
admet-2774	76	15	pcl	pcl	PROPN
admet-2774	76	16	nanoparticles	nanoparticle	NOUN
admet-2774	76	17	:	:	PUNCT
admet-2774	76	18	independent	independent	ADJ
admet-2774	76	19	variables	variable	NOUN
admet-2774	76	20	,	,	PUNCT
admet-2774	76	21	experimental	experimental	ADJ
admet-2774	76	22	results	result	NOUN
admet-2774	76	23	of	of	ADP
admet-2774	76	24	dependent	dependent	ADJ
admet-2774	76	25	variables	variable	NOUN
admet-2774	76	26	.	.	PUNCT
admet-2774	77	1	independent	independent	ADJ
admet-2774	77	2	variables	variable	NOUN
admet-2774	77	3	dependent	dependent	ADJ
admet-2774	77	4	variables	variable	NOUN
admet-2774	77	5	factor	factor	NOUN
admet-2774	77	6	1	1	NUM
admet-2774	77	7	(	(	PUNCT
admet-2774	77	8	x1	x1	ADJ
admet-2774	77	9	)	)	PUNCT
admet-2774	77	10	factor	factor	NOUN
admet-2774	77	11	2	2	NUM
admet-2774	77	12	(	(	PUNCT
admet-2774	77	13	x2	x2	ADJ
admet-2774	77	14	)	)	PUNCT
admet-2774	77	15	factor	factor	NOUN
admet-2774	77	16	3	3	NUM
admet-2774	77	17	(	(	PUNCT
admet-2774	77	18	x3	x3	ADJ
admet-2774	77	19	)	)	PUNCT
admet-2774	77	20	response	response	NOUN
admet-2774	77	21	1	1	NUM
admet-2774	77	22	(	(	PUNCT
admet-2774	77	23	y1	y1	NOUN
admet-2774	77	24	)	)	PUNCT
admet-2774	77	25	response	response	NOUN
admet-2774	77	26	2	2	NUM
admet-2774	77	27	(	(	PUNCT
admet-2774	77	28	y2	y2	NOUN
admet-2774	77	29	)	)	PUNCT
admet-2774	77	30	response	response	NOUN
admet-2774	77	31	3	3	NUM
admet-2774	77	32	(	(	PUNCT
admet-2774	77	33	y3	y3	NOUN
admet-2774	77	34	)	)	PUNCT
admet-2774	77	35	1	1	NUM
admet-2774	77	36	0	0	NUM
admet-2774	77	37	0	0	NUM
admet-2774	77	38	0	0	NUM
admet-2774	77	39	201.1	201.1	NUM
admet-2774	77	40	0.221	0.221	NUM
admet-2774	77	41	-19.3	-19.3	PRON
admet-2774	77	42	2	2	NUM
admet-2774	77	43	0	0	NUM
admet-2774	77	44	0	0	NUM
admet-2774	77	45	0	0	NUM
admet-2774	77	46	153.2	153.2	NUM
admet-2774	77	47	0.235	0.235	NUM
admet-2774	77	48	-20.2	-20.2	NUM
admet-2774	77	49	3	3	NUM
admet-2774	77	50	0	0	NUM
admet-2774	77	51	-1	-1	SYM
admet-2774	77	52	1	1	NUM
admet-2774	77	53	267	267	NUM
admet-2774	77	54	0.086	0.086	NUM
admet-2774	77	55	-20.4	-20.4	NUM
admet-2774	77	56	4	4	NUM
admet-2774	77	57	0	0	NUM
admet-2774	77	58	0	0	NUM
admet-2774	77	59	0	0	NUM
admet-2774	78	1	136.5	136.5	NUM
admet-2774	78	2	0.253	0.253	NUM
admet-2774	78	3	-16.3	-16.3	NUM
admet-2774	78	4	5	5	NUM
admet-2774	78	5	0	0	NUM
admet-2774	78	6	1	1	NUM
admet-2774	78	7	-1	-1	ADP
admet-2774	78	8	321.9	321.9	NUM
admet-2774	78	9	0.269	0.269	NUM
admet-2774	78	10	-24.3	-24.3	NUM
admet-2774	78	11	6	6	NUM
admet-2774	78	12	-1	-1	SYM
admet-2774	78	13	1	1	NUM
admet-2774	78	14	0	0	NUM
admet-2774	78	15	212.8	212.8	NUM
admet-2774	78	16	0.161	0.161	NUM
admet-2774	78	17	-21.8	-21.8	PUNCT
admet-2774	78	18	7	7	NUM
admet-2774	78	19	-1	-1	SYM
admet-2774	78	20	0	0	NUM
admet-2774	78	21	-1	-1	CCONJ
admet-2774	78	22	193.1	193.1	NUM
admet-2774	78	23	0.295	0.295	NUM
admet-2774	78	24	-22.21	-22.21	PROPN
admet-2774	78	25	8	8	NUM
admet-2774	78	26	1	1	NUM
admet-2774	78	27	-1	-1	SYM
admet-2774	78	28	0	0	NUM
admet-2774	78	29	169.7	169.7	NUM
admet-2774	78	30	0.139	0.139	NUM
admet-2774	78	31	-11.4	-11.4	NOUN
admet-2774	78	32	9	9	NUM
admet-2774	78	33	1	1	NUM
admet-2774	78	34	0	0	NUM
admet-2774	78	35	-1	-1	ADP
admet-2774	78	36	190.3	190.3	NUM
admet-2774	78	37	0.209	0.209	NUM
admet-2774	78	38	-16.4	-16.4	NUM
admet-2774	78	39	10	10	NUM
admet-2774	78	40	1	1	NUM
admet-2774	78	41	1	1	NUM
admet-2774	78	42	0	0	NUM
admet-2774	78	43	248.4	248.4	NUM
admet-2774	78	44	0.067	0.067	NUM
admet-2774	78	45	-24.8	-24.8	NUM
admet-2774	78	46	11	11	NUM
admet-2774	78	47	-1	-1	SYM
admet-2774	78	48	0	0	NUM
admet-2774	78	49	1	1	NUM
admet-2774	78	50	211.5	211.5	NUM
admet-2774	78	51	0.071	0.071	NUM
admet-2774	78	52	-21.3	-21.3	NUM
admet-2774	78	53	12	12	NUM
admet-2774	78	54	0	0	NUM
admet-2774	78	55	0	0	NUM
admet-2774	78	56	0	0	NUM
admet-2774	78	57	164.9	164.9	NUM
admet-2774	78	58	0.119	0.119	NUM
admet-2774	78	59	-16.78	-16.78	NUM
admet-2774	78	60	13	13	NUM
admet-2774	78	61	1	1	NUM
admet-2774	78	62	0	0	NUM
admet-2774	78	63	1	1	NUM
admet-2774	78	64	207.5	207.5	NUM
admet-2774	78	65	0.088	0.088	NUM
admet-2774	78	66	-14.9	-14.9	NUM
admet-2774	78	67	14	14	NUM
admet-2774	78	68	-1	-1	NOUN
admet-2774	78	69	-1	-1	CCONJ
admet-2774	78	70	0	0	NUM
admet-2774	78	71	268.4	268.4	NUM
admet-2774	78	72	0.105	0.105	NUM
admet-2774	78	73	-11.5	-11.5	NUM
admet-2774	78	74	15	15	NUM
admet-2774	78	75	0	0	NUM
admet-2774	78	76	0	0	NUM
admet-2774	78	77	0	0	NUM
admet-2774	78	78	206.6	206.6	NUM
admet-2774	78	79	0.046	0.046	NUM
admet-2774	78	80	-17.28	-17.28	PUNCT
admet-2774	78	81	16	16	NUM
admet-2774	78	82	0	0	NUM
admet-2774	78	83	-1	-1	CCONJ
admet-2774	78	84	-1	-1	PROPN
admet-2774	79	1	182.23	182.23	NUM
admet-2774	79	2	0.261	0.261	NUM
admet-2774	79	3	-14.59	-14.59	SYM
admet-2774	79	4	17	17	NUM
admet-2774	79	5	0	0	NUM
admet-2774	79	6	1	1	NUM
admet-2774	79	7	1	1	NUM
admet-2774	79	8	196.35	196.35	NUM
admet-2774	79	9	0.178	0.178	NUM
admet-2774	79	10	-15.72	-15.72	PRON
admet-2774	79	11	particle	particle	NOUN
admet-2774	79	12	size	size	NOUN
admet-2774	79	13	,	,	PUNCT
admet-2774	79	14	polydispersity	polydispersity	NOUN
admet-2774	79	15	index	index	NOUN
admet-2774	79	16	and	and	CCONJ
admet-2774	79	17	surface	surface	NOUN
admet-2774	79	18	charge	charge	VERB
admet-2774	79	19	the	the	DET
admet-2774	79	20	physicochemical	physicochemical	ADJ
admet-2774	79	21	characterization	characterization	NOUN
admet-2774	79	22	of	of	ADP
admet-2774	79	23	inh	inh	NOUN
admet-2774	79	24	-	-	PUNCT
admet-2774	79	25	loaded	load	VERB
admet-2774	79	26	pcl	pcl	PROPN
admet-2774	79	27	nanoparticles	nanoparticle	NOUN
admet-2774	79	28	was	be	AUX
admet-2774	79	29	performed	perform	VERB
admet-2774	79	30	using	use	VERB
admet-2774	79	31	dynamic	dynamic	ADJ
admet-2774	79	32	light	light	NOUN
admet-2774	79	33	scattering	scatter	VERB
admet-2774	79	34	(	(	PUNCT
admet-2774	79	35	nano	nano	NOUN
admet-2774	79	36	zs	zs	PROPN
admet-2774	79	37	90	90	NUM
admet-2774	79	38	zetasizer	zetasizer	NOUN
admet-2774	79	39	,	,	PUNCT
admet-2774	79	40	malvern	malvern	PROPN
admet-2774	79	41	instruments	instruments	PROPN
admet-2774	79	42	ltd	ltd	PROPN
admet-2774	79	43	.	.	PROPN
admet-2774	79	44	,	,	PUNCT
admet-2774	79	45	uk	uk	PROPN
admet-2774	79	46	)	)	PUNCT
admet-2774	79	47	.	.	PUNCT
admet-2774	80	1	main	main	ADJ
admet-2774	80	2	parameters	parameter	NOUN
admet-2774	80	3	were	be	AUX
admet-2774	80	4	measured	measure	VERB
admet-2774	80	5	,	,	PUNCT
admet-2774	80	6	including	include	VERB
admet-2774	80	7	hydrodynamic	hydrodynamic	ADJ
admet-2774	80	8	diameter	diameter	NOUN
admet-2774	80	9	,	,	PUNCT
admet-2774	80	10	polydispersity	polydispersity	NOUN
admet-2774	80	11	index	index	NOUN
admet-2774	80	12	(	(	PUNCT
admet-2774	80	13	pdi	pdi	PROPN
admet-2774	80	14	)	)	PUNCT
admet-2774	80	15	,	,	PUNCT
admet-2774	80	16	and	and	CCONJ
admet-2774	80	17	surface	surface	NOUN
admet-2774	80	18	charge	charge	NOUN
admet-2774	80	19	(	(	PUNCT
admet-2774	80	20	zeta	zeta	NOUN
admet-2774	80	21	potential	potential	NOUN
admet-2774	80	22	)	)	PUNCT
admet-2774	80	23	.	.	PUNCT
admet-2774	81	1	for	for	ADP
admet-2774	81	2	analysis	analysis	NOUN
admet-2774	81	3	,	,	PUNCT
admet-2774	81	4	nanoparticle	nanoparticle	NOUN
admet-2774	81	5	suspensions	suspension	NOUN
admet-2774	81	6	were	be	AUX
admet-2774	81	7	diluted	dilute	VERB
admet-2774	81	8	(	(	PUNCT
admet-2774	81	9	0.1	0.1	NUM
admet-2774	81	10	ml	ml	NOUN
admet-2774	81	11	nanosuspension	nanosuspension	NOUN
admet-2774	81	12	in	in	ADP
admet-2774	81	13	2	2	NUM
admet-2774	81	14	ml	ml	ADV
admet-2774	81	15	deionized	deionize	VERB
admet-2774	81	16	water	water	NOUN
admet-2774	81	17	)	)	PUNCT
admet-2774	81	18	and	and	CCONJ
admet-2774	81	19	loaded	load	VERB
admet-2774	81	20	into	into	ADP
admet-2774	81	21	disposable	disposable	ADJ
admet-2774	81	22	cuvettes	cuvette	NOUN
admet-2774	81	23	.	.	PUNCT
admet-2774	82	1	measurements	measurement	NOUN
admet-2774	82	2	were	be	AUX
admet-2774	82	3	conducted	conduct	VERB
admet-2774	82	4	at	at	ADP
admet-2774	82	5	25	25	NUM
admet-2774	82	6	°	°	NOUN
admet-2774	82	7	c	c	NOUN
admet-2774	82	8	with	with	ADP
admet-2774	82	9	a	a	DET
admet-2774	82	10	173	173	NUM
admet-2774	82	11	°	°	NOUN
admet-2774	82	12	backscatter	backscatter	NOUN
admet-2774	82	13	angle	angle	NOUN
admet-2774	82	14	,	,	PUNCT
admet-2774	82	15	with	with	SCONJ
admet-2774	82	16	each	each	DET
admet-2774	82	17	sample	sample	NOUN
admet-2774	82	18	analysed	analyse	VERB
admet-2774	82	19	for	for	ADP
admet-2774	82	20	120	120	NUM
admet-2774	82	21	seconds	second	NOUN
admet-2774	83	1	[	[	X
admet-2774	83	2	33	33	NUM
admet-2774	83	3	]	]	PUNCT
admet-2774	83	4	.	.	PUNCT
admet-2774	84	1	triplicate	triplicate	VERB
admet-2774	84	2	measurements	measurement	NOUN
admet-2774	84	3	were	be	AUX
admet-2774	84	4	reported	report	VERB
admet-2774	84	5	as	as	ADP
admet-2774	84	6	mean	mean	NOUN
admet-2774	84	7	±	±	NUM
admet-2774	84	8	sd	sd	NOUN
admet-2774	84	9	.	.	PUNCT
admet-2774	85	1	https://www.statease.com/software/design-expert/	https://www.statease.com/software/design-expert/	PROPN
admet-2774	86	1	admet	admet	PROPN
admet-2774	86	2	&	&	CCONJ
admet-2774	86	3	dmpk	dmpk	PROPN
admet-2774	86	4	13(4	13(4	NUM
admet-2774	86	5	)	)	PUNCT
admet-2774	86	6	(	(	PUNCT
admet-2774	86	7	2025	2025	NUM
admet-2774	86	8	)	)	PUNCT
admet-2774	86	9	2774	2774	NUM
admet-2774	86	10	freeze	freeze	NOUN
admet-2774	86	11	-	-	PUNCT
admet-2774	86	12	dried	dry	VERB
admet-2774	86	13	isoniazid	isoniazid	NOUN
admet-2774	86	14	-	-	PUNCT
admet-2774	86	15	loaded	load	VERB
admet-2774	86	16	poly	poly	ADJ
admet-2774	86	17	-	-	PUNCT
admet-2774	86	18	ε	ε	NOUN
admet-2774	86	19	-	-	PUNCT
admet-2774	86	20	caprolactone	caprolactone	ADJ
admet-2774	86	21	nanoparticles	nanoparticle	NOUN
admet-2774	86	22	doi	doi	NOUN
admet-2774	86	23	:	:	PUNCT
admet-2774	86	24	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	86	25	5	5	NUM
admet-2774	86	26	encapsulation	encapsulation	NOUN
admet-2774	86	27	efficiency	efficiency	NOUN
admet-2774	86	28	and	and	CCONJ
admet-2774	86	29	drug	drug	NOUN
admet-2774	86	30	loading	load	VERB
admet-2774	86	31	the	the	DET
admet-2774	86	32	drug	drug	NOUN
admet-2774	86	33	encapsulation	encapsulation	NOUN
admet-2774	86	34	efficiency	efficiency	NOUN
admet-2774	86	35	of	of	ADP
admet-2774	86	36	inh	inh	NOUN
admet-2774	86	37	-	-	PUNCT
admet-2774	86	38	loaded	load	VERB
admet-2774	86	39	pcl	pcl	PROPN
admet-2774	86	40	nanoparticles	nanoparticle	NOUN
admet-2774	86	41	was	be	AUX
admet-2774	86	42	quantified	quantify	VERB
admet-2774	86	43	using	use	VERB
admet-2774	86	44	uv	uv	NOUN
admet-2774	86	45	-	-	PUNCT
admet-2774	86	46	vis	vis	X
admet-2774	86	47	spectroscopy	spectroscopy	NOUN
admet-2774	86	48	(	(	PUNCT
admet-2774	86	49	uv-2600i	uv-2600i	NOUN
admet-2774	86	50	,	,	PUNCT
admet-2774	86	51	shimadzu	shimadzu	NOUN
admet-2774	86	52	,	,	PUNCT
admet-2774	86	53	japan	japan	PROPN
admet-2774	86	54	)	)	PUNCT
admet-2774	86	55	.	.	PUNCT
admet-2774	87	1	the	the	DET
admet-2774	87	2	nanosuspension	nanosuspension	NOUN
admet-2774	87	3	was	be	AUX
admet-2774	87	4	centrifuged	centrifuge	VERB
admet-2774	87	5	at	at	ADP
admet-2774	87	6	10,000	10,000	NUM
admet-2774	87	7	rpm	rpm	NOUN
admet-2774	87	8	for	for	ADP
admet-2774	87	9	60	60	NUM
admet-2774	87	10	min	min	NOUN
admet-2774	87	11	at	at	ADP
admet-2774	87	12	4	4	NUM
admet-2774	87	13	°	°	ADP
admet-2774	87	14	c	c	NOUN
admet-2774	87	15	using	use	VERB
admet-2774	87	16	a	a	DET
admet-2774	87	17	thermo	thermo	NOUN
admet-2774	87	18	scientific	scientific	ADJ
admet-2774	87	19	sorvall	sorvall	PROPN
admet-2774	87	20	st	st	PROPN
admet-2774	87	21	8r	8r	PROPN
admet-2774	87	22	centrifuge	centrifuge	NOUN
admet-2774	87	23	to	to	PART
admet-2774	87	24	separate	separate	VERB
admet-2774	87	25	the	the	DET
admet-2774	87	26	free	free	ADJ
admet-2774	87	27	drug	drug	NOUN
admet-2774	87	28	from	from	ADP
admet-2774	87	29	the	the	DET
admet-2774	87	30	nanosuspension	nanosuspension	NOUN
admet-2774	87	31	.	.	PUNCT
admet-2774	88	1	the	the	DET
admet-2774	88	2	supernatant	supernatant	NOUN
admet-2774	88	3	containing	contain	VERB
admet-2774	88	4	unentrapped	unentrapped	ADJ
admet-2774	88	5	drug	drug	NOUN
admet-2774	88	6	was	be	AUX
admet-2774	88	7	analysed	analyse	VERB
admet-2774	88	8	at	at	ADP
admet-2774	88	9	262	262	NUM
admet-2774	88	10	nm	nm	NOUN
admet-2774	88	11	,	,	PUNCT
admet-2774	88	12	using	use	VERB
admet-2774	88	13	a	a	DET
admet-2774	88	14	pre	pre	ADJ
admet-2774	88	15	-	-	ADJ
admet-2774	88	16	established	established	ADJ
admet-2774	88	17	calibration	calibration	NOUN
admet-2774	88	18	curve	curve	NOUN
admet-2774	88	19	(	(	PUNCT
admet-2774	88	20	r²	r²	NOUN
admet-2774	88	21	=	=	SYM
admet-2774	88	22	0.9933	0.9933	NUM
admet-2774	88	23	)	)	PUNCT
admet-2774	89	1	[	[	X
admet-2774	89	2	27	27	NUM
admet-2774	89	3	]	]	PUNCT
admet-2774	89	4	.	.	PUNCT
admet-2774	90	1	ee	ee	PROPN
admet-2774	90	2	,	,	PUNCT
admet-2774	90	3	%	%	NOUN
admet-2774	90	4	and	and	CCONJ
admet-2774	90	5	drug	drug	NOUN
admet-2774	90	6	loading	loading	NOUN
admet-2774	90	7	(	(	PUNCT
admet-2774	90	8	dl	dl	PROPN
admet-2774	90	9	,	,	PUNCT
admet-2774	90	10	wt.%	wt.%	PROPN
admet-2774	90	11	)	)	PUNCT
admet-2774	90	12	were	be	AUX
admet-2774	90	13	calculated	calculate	VERB
admet-2774	90	14	using	use	VERB
admet-2774	90	15	standard	standard	ADJ
admet-2774	90	16	formulas	formula	NOUN
admet-2774	90	17	,	,	PUNCT
admet-2774	90	18	equations	equation	NOUN
admet-2774	90	19	(	(	PUNCT
admet-2774	90	20	1	1	NUM
admet-2774	90	21	)	)	PUNCT
admet-2774	90	22	and	and	CCONJ
admet-2774	90	23	(	(	PUNCT
admet-2774	90	24	2	2	NUM
admet-2774	90	25	)	)	PUNCT
admet-2774	90	26	,	,	PUNCT
admet-2774	90	27	with	with	ADP
admet-2774	90	28	all	all	DET
admet-2774	90	29	measurements	measurement	NOUN
admet-2774	90	30	performed	perform	VERB
admet-2774	90	31	in	in	ADP
admet-2774	90	32	triplicate	triplicate	NOUN
admet-2774	90	33	(	(	PUNCT
admet-2774	90	34	n=3	n=3	NOUN
admet-2774	90	35	)	)	PUNCT
admet-2774	90	36	.	.	PUNCT
admet-2774	91	1	weight	weight	NOUN
admet-2774	91	2	 	 	SPACE
admet-2774	91	3	of	of	ADP
admet-2774	91	4	 	 	SPACE
admet-2774	91	5	entraped	entrap	VERB
admet-2774	91	6	 	 	SPACE
admet-2774	91	7	inh	inh	PROPN
admet-2774	91	8	dl	dl	PROPN
admet-2774	91	9	100	100	NUM
admet-2774	91	10	   	   	SPACE
admet-2774	91	11	weight	weight	NOUN
admet-2774	91	12	 	 	SPACE
admet-2774	91	13	of	of	ADP
admet-2774	91	14	 	 	SPACE
admet-2774	91	15	nanoparticles	nanoparticle	NOUN
admet-2774	91	16	=	=	SYM
admet-2774	91	17	(	(	PUNCT
admet-2774	91	18	1	1	NUM
admet-2774	91	19	)	)	PUNCT
admet-2774	91	20	total	total	ADJ
admet-2774	91	21	 	 	SPACE
admet-2774	91	22	inh	inh	PROPN
admet-2774	91	23	 	 	SPACE
admet-2774	91	24	added	add	VERB
admet-2774	91	25	-	-	PUNCT
admet-2774	91	26	unbound	unbound	NOUN
admet-2774	91	27	 	 	SPACE
admet-2774	91	28	inh	inh	PROPN
admet-2774	91	29	ee	ee	PROPN
admet-2774	91	30	  	  	SPACE
admet-2774	91	31	100	100	NUM
admet-2774	91	32	total	total	ADJ
admet-2774	91	33	 	 	SPACE
admet-2774	91	34	inh	inh	PROPN
admet-2774	91	35	 	 	SPACE
admet-2774	91	36	added	add	VERB
admet-2774	91	37	=	=	SYM
admet-2774	91	38	(	(	PUNCT
admet-2774	91	39	2	2	X
admet-2774	91	40	)	)	PUNCT
admet-2774	91	41	particle	particle	NOUN
admet-2774	91	42	morphology	morphology	NOUN
admet-2774	91	43	the	the	DET
admet-2774	91	44	morphological	morphological	ADJ
admet-2774	91	45	characteristics	characteristic	NOUN
admet-2774	91	46	of	of	ADP
admet-2774	91	47	inh	inh	PROPN
admet-2774	91	48	-	-	PUNCT
admet-2774	91	49	loaded	load	VERB
admet-2774	91	50	pcl	pcl	PROPN
admet-2774	91	51	nanoparticles	nanoparticle	NOUN
admet-2774	91	52	were	be	AUX
admet-2774	91	53	analysed	analyse	VERB
admet-2774	91	54	using	use	VERB
admet-2774	91	55	field	field	NOUN
admet-2774	91	56	emission	emission	NOUN
admet-2774	91	57	scanning	scan	VERB
admet-2774	91	58	electron	electron	NOUN
admet-2774	91	59	microscopy	microscopy	NOUN
admet-2774	91	60	(	(	PUNCT
admet-2774	91	61	fe	fe	NOUN
admet-2774	91	62	-	-	NOUN
admet-2774	91	63	sem	sem	NOUN
admet-2774	91	64	;	;	PUNCT
admet-2774	91	65	jsm	jsm	PROPN
admet-2774	91	66	-	-	PUNCT
admet-2774	91	67	it300lv	it300lv	PROPN
admet-2774	91	68	,	,	PUNCT
admet-2774	91	69	jeol	jeol	PROPN
admet-2774	91	70	,	,	PUNCT
admet-2774	91	71	japan	japan	PROPN
admet-2774	91	72	)	)	PUNCT
admet-2774	91	73	.	.	PUNCT
admet-2774	92	1	before	before	ADP
admet-2774	92	2	imaging	imaging	NOUN
admet-2774	92	3	,	,	PUNCT
admet-2774	92	4	samples	sample	NOUN
admet-2774	92	5	were	be	AUX
admet-2774	92	6	sputtercoated	sputtercoate	VERB
admet-2774	92	7	with	with	ADP
admet-2774	92	8	a	a	DET
admet-2774	92	9	10	10	NUM
admet-2774	92	10	nm	nm	ADJ
admet-2774	92	11	gold	gold	NOUN
admet-2774	92	12	layer	layer	NOUN
admet-2774	92	13	(	(	PUNCT
admet-2774	92	14	jce-3000fc	jce-3000fc	ADJ
admet-2774	92	15	coating	coating	NOUN
admet-2774	92	16	system	system	NOUN
admet-2774	92	17	,	,	PUNCT
admet-2774	92	18	jeol	jeol	PROPN
admet-2774	92	19	,	,	PUNCT
admet-2774	92	20	japan	japan	PROPN
admet-2774	92	21	)	)	PUNCT
admet-2774	92	22	for	for	ADP
admet-2774	92	23	50	50	NUM
admet-2774	92	24	s	s	NOUN
admet-2774	92	25	to	to	PART
admet-2774	92	26	ensure	ensure	VERB
admet-2774	92	27	conductivity	conductivity	NOUN
admet-2774	92	28	and	and	CCONJ
admet-2774	92	29	imaged	image	VERB
admet-2774	92	30	at	at	ADP
admet-2774	92	31	10	10	NUM
admet-2774	92	32	kv	kv	NOUN
admet-2774	92	33	accelerating	accelerate	VERB
admet-2774	92	34	voltage	voltage	NOUN
admet-2774	92	35	in	in	ADP
admet-2774	92	36	secondary	secondary	ADJ
admet-2774	92	37	electron	electron	NOUN
admet-2774	92	38	detection	detection	NOUN
admet-2774	92	39	mode[31,34	mode[31,34	PROPN
admet-2774	92	40	]	]	PUNCT
admet-2774	92	41	.	.	PUNCT
admet-2774	93	1	redispersibility	redispersibility	VERB
admet-2774	93	2	the	the	DET
admet-2774	93	3	reconstitution	reconstitution	NOUN
admet-2774	93	4	properties	property	NOUN
admet-2774	93	5	of	of	ADP
admet-2774	93	6	lyophilized	lyophilized	ADJ
admet-2774	93	7	inh	inh	PROPN
admet-2774	93	8	-	-	PUNCT
admet-2774	93	9	loaded	load	VERB
admet-2774	93	10	pcl	pcl	PROPN
admet-2774	93	11	nanoparticles	nanoparticle	NOUN
admet-2774	93	12	were	be	AUX
admet-2774	93	13	evaluated	evaluate	VERB
admet-2774	93	14	by	by	ADP
admet-2774	93	15	dispersing	disperse	VERB
admet-2774	93	16	2	2	NUM
admet-2774	93	17	mg	mg	ADP
admet-2774	93	18	of	of	ADP
admet-2774	93	19	the	the	DET
admet-2774	93	20	freeze	freeze	NOUN
admet-2774	93	21	-	-	PUNCT
admet-2774	93	22	dried	dry	VERB
admet-2774	93	23	powder	powder	NOUN
admet-2774	93	24	in	in	ADP
admet-2774	93	25	2	2	NUM
admet-2774	93	26	ml	ml	NOUN
admet-2774	93	27	of	of	ADP
admet-2774	93	28	purified	purified	ADJ
admet-2774	93	29	water	water	NOUN
admet-2774	93	30	(	(	PUNCT
admet-2774	93	31	milli	milli	ADJ
admet-2774	93	32	-	-	PUNCT
admet-2774	93	33	q	q	NOUN
admet-2774	93	34	grade	grade	NOUN
admet-2774	93	35	)	)	PUNCT
admet-2774	93	36	.	.	PUNCT
admet-2774	94	1	the	the	DET
admet-2774	94	2	redispersed	redisperse	VERB
admet-2774	94	3	nanoparticles	nanoparticle	NOUN
admet-2774	94	4	were	be	AUX
admet-2774	94	5	subsequently	subsequently	ADV
admet-2774	94	6	characterized	characterize	VERB
admet-2774	94	7	for	for	ADP
admet-2774	94	8	particle	particle	NOUN
admet-2774	94	9	size	size	NOUN
admet-2774	94	10	distribution	distribution	NOUN
admet-2774	94	11	and	and	CCONJ
admet-2774	94	12	surface	surface	NOUN
admet-2774	94	13	charge	charge	NOUN
admet-2774	94	14	using	use	VERB
admet-2774	94	15	the	the	DET
admet-2774	94	16	dynamic	dynamic	ADJ
admet-2774	94	17	light	light	NOUN
admet-2774	94	18	scattering	scatter	VERB
admet-2774	94	19	technique	technique	NOUN
admet-2774	94	20	[	[	X
admet-2774	94	21	27	27	NUM
admet-2774	94	22	]	]	PUNCT
admet-2774	94	23	.	.	PUNCT
admet-2774	95	1	fourier	fourier	PROPN
admet-2774	95	2	transform	transform	VERB
admet-2774	95	3	infrared	infrared	ADJ
admet-2774	95	4	spectroscopy	spectroscopy	NOUN
admet-2774	95	5	fourier	fourier	NOUN
admet-2774	95	6	-	-	PUNCT
admet-2774	95	7	transform	transform	NOUN
admet-2774	95	8	infrared	infrared	ADJ
admet-2774	95	9	spectroscopy	spectroscopy	NOUN
admet-2774	95	10	(	(	PUNCT
admet-2774	95	11	ft	ft	NOUN
admet-2774	95	12	-	-	PUNCT
admet-2774	95	13	ir	ir	NOUN
admet-2774	95	14	)	)	PUNCT
admet-2774	95	15	analysis	analysis	NOUN
admet-2774	95	16	was	be	AUX
admet-2774	95	17	performed	perform	VERB
admet-2774	95	18	using	use	VERB
admet-2774	95	19	a	a	DET
admet-2774	95	20	spectrum	spectrum	NOUN
admet-2774	95	21	two	two	NUM
admet-2774	95	22	spectrometer	spectrometer	NOUN
admet-2774	95	23	(	(	PUNCT
admet-2774	95	24	perkinelmer	perkinelmer	NOUN
admet-2774	95	25	,	,	PUNCT
admet-2774	95	26	usa	usa	NOUN
admet-2774	95	27	)	)	PUNCT
admet-2774	95	28	equipped	equip	VERB
admet-2774	95	29	with	with	ADP
admet-2774	95	30	a	a	DET
admet-2774	95	31	universal	universal	ADJ
admet-2774	95	32	atr	atr	NOUN
admet-2774	95	33	accessory	accessory	NOUN
admet-2774	95	34	(	(	PUNCT
admet-2774	95	35	diamond	diamond	NOUN
admet-2774	95	36	/	/	SYM
admet-2774	95	37	znse	znse	NOUN
admet-2774	95	38	crystal	crystal	NOUN
admet-2774	95	39	)	)	PUNCT
admet-2774	95	40	.	.	PUNCT
admet-2774	96	1	samples	sample	NOUN
admet-2774	96	2	were	be	AUX
admet-2774	96	3	analysed	analyse	VERB
admet-2774	96	4	in	in	ADP
admet-2774	96	5	their	their	PRON
admet-2774	96	6	pure	pure	ADJ
admet-2774	96	7	form	form	NOUN
admet-2774	96	8	by	by	ADP
admet-2774	96	9	direct	direct	ADJ
admet-2774	96	10	placement	placement	NOUN
admet-2774	96	11	on	on	ADP
admet-2774	96	12	the	the	DET
admet-2774	96	13	atr	atr	PROPN
admet-2774	96	14	crystal	crystal	NOUN
admet-2774	96	15	.	.	PUNCT
admet-2774	97	1	spectral	spectral	ADJ
admet-2774	97	2	data	datum	NOUN
admet-2774	97	3	were	be	AUX
admet-2774	97	4	collected	collect	VERB
admet-2774	97	5	in	in	ADP
admet-2774	97	6	transmission	transmission	NOUN
admet-2774	97	7	mode	mode	NOUN
admet-2774	97	8	with	with	ADP
admet-2774	97	9	a	a	DET
admet-2774	97	10	4	4	NUM
admet-2774	97	11	cm-¹	cm-¹	NOUN
admet-2774	97	12	resolution	resolution	NOUN
admet-2774	97	13	,	,	PUNCT
admet-2774	97	14	averaging	average	VERB
admet-2774	97	15	16	16	NUM
admet-2774	97	16	scans	scan	NOUN
admet-2774	97	17	per	per	ADP
admet-2774	97	18	measurement	measurement	NOUN
admet-2774	97	19	under	under	ADP
admet-2774	97	20	continuous	continuous	ADJ
admet-2774	97	21	dry	dry	ADJ
admet-2774	97	22	air	air	NOUN
admet-2774	97	23	purge	purge	NOUN
admet-2774	97	24	[	[	X
admet-2774	97	25	35	35	NUM
admet-2774	97	26	]	]	PUNCT
admet-2774	97	27	.	.	PUNCT
admet-2774	98	1	the	the	DET
admet-2774	98	2	analysis	analysis	NOUN
admet-2774	98	3	covered	cover	VERB
admet-2774	98	4	the	the	DET
admet-2774	98	5	mid	mid	ADJ
admet-2774	98	6	-	-	ADJ
admet-2774	98	7	infrared	infrared	ADJ
admet-2774	98	8	region	region	NOUN
admet-2774	98	9	(	(	PUNCT
admet-2774	98	10	4000	4000	NUM
admet-2774	98	11	to	to	ADP
admet-2774	98	12	400	400	NUM
admet-2774	98	13	cm-¹	cm-¹	NOUN
admet-2774	98	14	)	)	PUNCT
admet-2774	98	15	for	for	ADP
admet-2774	98	16	pure	pure	ADJ
admet-2774	98	17	inh	inh	PROPN
admet-2774	98	18	,	,	PUNCT
admet-2774	98	19	pcl	pcl	PROPN
admet-2774	98	20	,	,	PUNCT
admet-2774	98	21	poloxamer	poloxamer	NOUN
admet-2774	98	22	188	188	NUM
admet-2774	98	23	,	,	PUNCT
admet-2774	98	24	and	and	CCONJ
admet-2774	98	25	the	the	DET
admet-2774	98	26	inh	inh	NOUN
admet-2774	98	27	-	-	PUNCT
admet-2774	98	28	loaded	load	VERB
admet-2774	98	29	nanoparticle	nanoparticle	NOUN
admet-2774	98	30	formulation	formulation	NOUN
admet-2774	98	31	.	.	PUNCT
admet-2774	99	1	differential	differential	PROPN
admet-2774	99	2	scanning	scan	VERB
admet-2774	99	3	calorimetry	calorimetry	NOUN
admet-2774	99	4	the	the	DET
admet-2774	99	5	thermal	thermal	ADJ
admet-2774	99	6	behaviour	behaviour	NOUN
admet-2774	99	7	of	of	ADP
admet-2774	99	8	pure	pure	ADJ
admet-2774	99	9	inh	inh	PROPN
admet-2774	99	10	,	,	PUNCT
admet-2774	99	11	pcl	pcl	PROPN
admet-2774	99	12	,	,	PUNCT
admet-2774	99	13	poloxamer	poloxamer	NOUN
admet-2774	99	14	188	188	NUM
admet-2774	99	15	,	,	PUNCT
admet-2774	99	16	and	and	CCONJ
admet-2774	99	17	the	the	DET
admet-2774	99	18	inh	inh	NOUN
admet-2774	99	19	-	-	PUNCT
admet-2774	99	20	loaded	load	VERB
admet-2774	99	21	nanoparticle	nanoparticle	NOUN
admet-2774	99	22	powder	powder	NOUN
admet-2774	99	23	formulations	formulation	NOUN
admet-2774	99	24	was	be	AUX
admet-2774	99	25	analysed	analyse	VERB
admet-2774	99	26	using	use	VERB
admet-2774	99	27	a	a	DET
admet-2774	99	28	differential	differential	ADJ
admet-2774	99	29	scanning	scan	VERB
admet-2774	99	30	calorimeter	calorimeter	NOUN
admet-2774	99	31	(	(	PUNCT
admet-2774	99	32	dsc-7020	dsc-7020	NOUN
admet-2774	99	33	,	,	PUNCT
admet-2774	99	34	hitachi	hitachi	PROPN
admet-2774	99	35	high	high	ADJ
admet-2774	99	36	-	-	PUNCT
admet-2774	99	37	tech	tech	NOUN
admet-2774	99	38	corporation	corporation	NOUN
admet-2774	99	39	,	,	PUNCT
admet-2774	99	40	japan	japan	PROPN
admet-2774	99	41	)	)	PUNCT
admet-2774	99	42	.	.	PUNCT
admet-2774	100	1	approximately	approximately	ADV
admet-2774	100	2	5	5	NUM
admet-2774	100	3	mg	mg	NOUN
admet-2774	100	4	of	of	ADP
admet-2774	100	5	each	each	DET
admet-2774	100	6	sample	sample	NOUN
admet-2774	100	7	was	be	AUX
admet-2774	100	8	placed	place	VERB
admet-2774	100	9	in	in	ADP
admet-2774	100	10	hermetically	hermetically	NOUN
admet-2774	100	11	sealed	seal	VERB
admet-2774	100	12	aluminium	aluminium	NOUN
admet-2774	100	13	crucibles	crucible	NOUN
admet-2774	100	14	and	and	CCONJ
admet-2774	100	15	subjected	subject	VERB
admet-2774	100	16	to	to	ADP
admet-2774	100	17	a	a	DET
admet-2774	100	18	heating	heating	NOUN
admet-2774	100	19	program	program	NOUN
admet-2774	100	20	from	from	ADP
admet-2774	100	21	30	30	NUM
admet-2774	100	22	 	 	SPACE
admet-2774	100	23	to	to	ADP
admet-2774	100	24	700	700	NUM
admet-2774	100	25	 	 	SPACE
admet-2774	100	26	°	°	NOUN
admet-2774	100	27	c	c	NOUN
admet-2774	100	28	at	at	ADP
admet-2774	100	29	20	20	NUM
admet-2774	100	30	 	 	SPACE
admet-2774	100	31	°	°	PROPN
admet-2774	100	32	c	c	NOUN
admet-2774	100	33	per	per	ADP
admet-2774	100	34	minute	minute	NOUN
admet-2774	100	35	,	,	PUNCT
admet-2774	100	36	under	under	ADP
admet-2774	100	37	a	a	DET
admet-2774	100	38	constant	constant	ADJ
admet-2774	100	39	nitrogen	nitrogen	NOUN
admet-2774	100	40	atmosphere	atmosphere	NOUN
admet-2774	100	41	.	.	PUNCT
admet-2774	101	1	the	the	DET
admet-2774	101	2	thermograms	thermogram	NOUN
admet-2774	101	3	obtained	obtain	VERB
admet-2774	101	4	were	be	AUX
admet-2774	101	5	analysed	analyse	VERB
admet-2774	101	6	using	use	VERB
admet-2774	101	7	ta7000	ta7000	ADJ
admet-2774	101	8	software	software	NOUN
admet-2774	101	9	(	(	PUNCT
admet-2774	101	10	hitachi	hitachi	PROPN
admet-2774	101	11	high	high	ADJ
admet-2774	101	12	-	-	PUNCT
admet-2774	101	13	tech	tech	NOUN
admet-2774	101	14	corporation	corporation	NOUN
admet-2774	101	15	,	,	PUNCT
admet-2774	101	16	japan	japan	PROPN
admet-2774	101	17	)	)	PUNCT
admet-2774	102	1	[	[	X
admet-2774	102	2	36,37	36,37	X
admet-2774	102	3	]	]	PUNCT
admet-2774	102	4	.	.	PUNCT
admet-2774	103	1	x	x	X
admet-2774	103	2	-	-	PUNCT
admet-2774	103	3	ray	ray	NOUN
admet-2774	103	4	diffraction	diffraction	NOUN
admet-2774	103	5	study	study	VERB
admet-2774	103	6	the	the	DET
admet-2774	103	7	powdered	powdered	ADJ
admet-2774	103	8	sample	sample	NOUN
admet-2774	103	9	's	's	PART
admet-2774	103	10	crystalline	crystalline	NOUN
admet-2774	103	11	properties	property	NOUN
admet-2774	103	12	and	and	CCONJ
admet-2774	103	13	physical	physical	ADJ
admet-2774	103	14	state	state	NOUN
admet-2774	103	15	were	be	AUX
admet-2774	103	16	investigated	investigate	VERB
admet-2774	103	17	using	use	VERB
admet-2774	103	18	an	an	DET
admet-2774	103	19	x	x	ADJ
admet-2774	103	20	-	-	NOUN
admet-2774	103	21	ray	ray	NOUN
admet-2774	103	22	diffractometer	diffractometer	NOUN
admet-2774	103	23	(	(	PUNCT
admet-2774	103	24	bruker	bruker	PROPN
admet-2774	103	25	axs	axs	PROPN
admet-2774	103	26	d8	d8	PROPN
admet-2774	103	27	focus	focus	NOUN
admet-2774	103	28	)	)	PUNCT
admet-2774	103	29	equipped	equip	VERB
admet-2774	103	30	with	with	ADP
admet-2774	103	31	a	a	DET
admet-2774	103	32	cu	cu	NOUN
admet-2774	103	33	kα	kα	NOUN
admet-2774	103	34	radiation	radiation	NOUN
admet-2774	103	35	source	source	NOUN
admet-2774	103	36	(	(	PUNCT
admet-2774	103	37	λ	λ	X
admet-2774	103	38	=	=	NOUN
admet-2774	103	39	0.15406	0.15406	NUM
admet-2774	103	40	nm	nm	NOUN
admet-2774	103	41	)	)	PUNCT
admet-2774	103	42	.	.	PUNCT
admet-2774	104	1	the	the	DET
admet-2774	104	2	instrument	instrument	NOUN
admet-2774	104	3	was	be	AUX
admet-2774	104	4	set	set	VERB
admet-2774	104	5	to	to	ADP
admet-2774	104	6	an	an	DET
admet-2774	104	7	operating	operating	NOUN
admet-2774	104	8	voltage	voltage	NOUN
admet-2774	104	9	of	of	ADP
admet-2774	104	10	40	40	NUM
admet-2774	104	11	kv	kv	NOUN
admet-2774	104	12	and	and	CCONJ
admet-2774	104	13	a	a	DET
admet-2774	104	14	current	current	NOUN
admet-2774	104	15	of	of	ADP
admet-2774	104	16	40	40	NUM
admet-2774	104	17	ma	ma	PROPN
admet-2774	104	18	.	.	PUNCT
admet-2774	104	19	samples	sample	NOUN
admet-2774	104	20	of	of	ADP
admet-2774	104	21	pure	pure	ADJ
admet-2774	104	22	inh	inh	PROPN
admet-2774	104	23	,	,	PUNCT
admet-2774	104	24	pcl	pcl	PROPN
admet-2774	104	25	,	,	PUNCT
admet-2774	104	26	poloxamer	poloxamer	NOUN
admet-2774	104	27	188	188	NUM
admet-2774	104	28	,	,	PUNCT
admet-2774	104	29	and	and	CCONJ
admet-2774	104	30	the	the	DET
admet-2774	104	31	inh	inh	NOUN
admet-2774	104	32	-	-	PUNCT
admet-2774	104	33	loaded	load	VERB
admet-2774	104	34	nanoparticle	nanoparticle	NOUN
admet-2774	104	35	formulation	formulation	NOUN
admet-2774	104	36	were	be	AUX
admet-2774	104	37	prepared	prepare	VERB
admet-2774	104	38	by	by	ADP
admet-2774	104	39	evenly	evenly	ADV
admet-2774	104	40	spreading	spread	VERB
admet-2774	104	41	the	the	DET
admet-2774	104	42	powder	powder	NOUN
admet-2774	104	43	into	into	ADP
admet-2774	104	44	plastic	plastic	ADJ
admet-2774	104	45	sample	sample	NOUN
admet-2774	105	1	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	PROPN
admet-2774	105	2	e.	e.	PROPN
admet-2774	105	3	kole	kole	PROPN
admet-2774	105	4	et	et	PROPN
admet-2774	105	5	al	al	PROPN
admet-2774	105	6	.	.	PROPN
admet-2774	105	7	admet	admet	PROPN
admet-2774	105	8	&	&	CCONJ
admet-2774	105	9	dmpk	dmpk	PROPN
admet-2774	105	10	13(4	13(4	NUM
admet-2774	105	11	)	)	PUNCT
admet-2774	105	12	(	(	PUNCT
admet-2774	105	13	2025	2025	NUM
admet-2774	105	14	)	)	PUNCT
admet-2774	105	15	2774	2774	NUM
admet-2774	105	16	6	6	NUM
admet-2774	105	17	holders	holder	NOUN
admet-2774	105	18	and	and	CCONJ
admet-2774	105	19	gently	gently	ADV
admet-2774	105	20	flattening	flatten	VERB
admet-2774	105	21	the	the	DET
admet-2774	105	22	surface	surface	NOUN
admet-2774	105	23	with	with	ADP
admet-2774	105	24	a	a	DET
admet-2774	105	25	glass	glass	NOUN
admet-2774	105	26	slide	slide	NOUN
admet-2774	105	27	[	[	X
admet-2774	105	28	38,39	38,39	NOUN
admet-2774	105	29	]	]	X
admet-2774	105	30	.	.	PUNCT
admet-2774	106	1	xrd	xrd	PROPN
admet-2774	106	2	scans	scans	PROPN
admet-2774	106	3	were	be	AUX
admet-2774	106	4	performed	perform	VERB
admet-2774	106	5	at	at	ADP
admet-2774	106	6	ambient	ambient	ADJ
admet-2774	106	7	temperature	temperature	NOUN
admet-2774	106	8	,	,	PUNCT
admet-2774	106	9	covering	cover	VERB
admet-2774	106	10	a	a	DET
admet-2774	106	11	2	2	NOUN
admet-2774	106	12	angular	angular	ADJ
admet-2774	106	13	range	range	NOUN
admet-2774	106	14	from	from	ADP
admet-2774	106	15	5	5	NUM
admet-2774	106	16	°	°	NOUN
admet-2774	106	17	to	to	ADP
admet-2774	106	18	60	60	NUM
admet-2774	106	19	°	°	NOUN
admet-2774	106	20	with	with	ADP
admet-2774	106	21	a	a	DET
admet-2774	106	22	step	step	NOUN
admet-2774	106	23	size	size	NOUN
admet-2774	106	24	of	of	ADP
admet-2774	106	25	0.02	0.02	NUM
admet-2774	106	26	°	°	NUM
admet-2774	106	27	and	and	CCONJ
admet-2774	106	28	a	a	DET
admet-2774	106	29	scanning	scanning	NOUN
admet-2774	106	30	rate	rate	NOUN
admet-2774	106	31	of	of	ADP
admet-2774	106	32	1	1	NUM
admet-2774	106	33	°	°	NOUN
admet-2774	106	34	min-1	min-1	X
admet-2774	106	35	.	.	PUNCT
admet-2774	107	1	in	in	ADP
admet-2774	107	2	vitro	vitro	X
admet-2774	107	3	aerosolization	aerosolization	NOUN
admet-2774	107	4	study	study	NOUN
admet-2774	107	5	a	a	DET
admet-2774	107	6	next	next	ADJ
admet-2774	107	7	generation	generation	NOUN
admet-2774	107	8	impactor	impactor	NOUN
admet-2774	107	9	(	(	PUNCT
admet-2774	107	10	ngi	ngi	PROPN
admet-2774	107	11	,	,	PUNCT
admet-2774	107	12	copley	copley	NOUN
admet-2774	107	13	scientific	scientific	PROPN
admet-2774	107	14	,	,	PUNCT
admet-2774	107	15	uk	uk	PROPN
admet-2774	107	16	)	)	PUNCT
admet-2774	107	17	connected	connect	VERB
admet-2774	107	18	to	to	ADP
admet-2774	107	19	a	a	DET
admet-2774	107	20	rotahaler	rotahaler	NOUN
admet-2774	107	21	®	®	NOUN
admet-2774	107	22	(	(	PUNCT
admet-2774	107	23	cipla	cipla	NOUN
admet-2774	107	24	)	)	PUNCT
admet-2774	107	25	assessed	assess	VERB
admet-2774	107	26	the	the	DET
admet-2774	107	27	aerodynamic	aerodynamic	ADJ
admet-2774	107	28	properties	property	NOUN
admet-2774	107	29	of	of	ADP
admet-2774	107	30	lyophilized	lyophilized	ADJ
admet-2774	107	31	inh	inh	PROPN
admet-2774	107	32	-	-	PUNCT
admet-2774	107	33	pcl	pcl	PROPN
admet-2774	107	34	nanoparticles	nanoparticle	NOUN
admet-2774	107	35	.	.	PUNCT
admet-2774	108	1	exactly	exactly	ADV
admet-2774	108	2	50	50	NUM
admet-2774	108	3	mg	mg	NOUN
admet-2774	108	4	of	of	ADP
admet-2774	108	5	powder	powder	NOUN
admet-2774	108	6	blended	blend	VERB
admet-2774	108	7	with	with	ADP
admet-2774	108	8	lactose	lactose	NOUN
admet-2774	108	9	was	be	AUX
admet-2774	108	10	loaded	load	VERB
admet-2774	108	11	into	into	ADP
admet-2774	108	12	size-3	size-3	NUM
admet-2774	108	13	capsules	capsule	NOUN
admet-2774	108	14	.	.	PUNCT
admet-2774	109	1	using	use	VERB
admet-2774	109	2	a	a	DET
admet-2774	109	3	calibrated	calibrate	VERB
admet-2774	109	4	vacuum	vacuum	NOUN
admet-2774	109	5	pump	pump	NOUN
admet-2774	109	6	,	,	PUNCT
admet-2774	109	7	the	the	DET
admet-2774	109	8	system	system	NOUN
admet-2774	109	9	operated	operate	VERB
admet-2774	109	10	at	at	ADP
admet-2774	109	11	60	60	NUM
admet-2774	109	12	l	l	NOUN
admet-2774	109	13	/	/	SYM
admet-2774	109	14	min	min	NOUN
admet-2774	109	15	for	for	ADP
admet-2774	109	16	4	4	NUM
admet-2774	109	17	s.	s.	PROPN
admet-2774	109	18	upon	upon	SCONJ
admet-2774	109	19	actuation	actuation	NOUN
admet-2774	109	20	,	,	PUNCT
admet-2774	109	21	particles	particle	NOUN
admet-2774	109	22	are	be	AUX
admet-2774	109	23	deposited	deposit	VERB
admet-2774	109	24	across	across	ADP
admet-2774	109	25	ngi	ngi	PROPN
admet-2774	109	26	stages	stage	NOUN
admet-2774	109	27	(	(	PUNCT
admet-2774	109	28	0.54	0.54	NUM
admet-2774	109	29	-	-	SYM
admet-2774	109	30	8.06	8.06	NUM
admet-2774	109	31	μm	μm	NOUN
admet-2774	109	32	cutoff	cutoff	NOUN
admet-2774	109	33	diameters	diameter	NOUN
admet-2774	109	34	)	)	PUNCT
admet-2774	109	35	.	.	PUNCT
admet-2774	110	1	the	the	DET
admet-2774	110	2	gravimetric	gravimetric	ADJ
admet-2774	110	3	analysis	analysis	NOUN
admet-2774	110	4	determined	determine	VERB
admet-2774	110	5	emitted	emit	VERB
admet-2774	110	6	dose	dose	PROPN
admet-2774	110	7	(	(	PUNCT
admet-2774	110	8	ed	ed	NOUN
admet-2774	110	9	)	)	PUNCT
admet-2774	110	10	,	,	PUNCT
admet-2774	110	11	fine	fine	ADJ
admet-2774	110	12	particle	particle	NOUN
admet-2774	110	13	fraction	fraction	NOUN
admet-2774	110	14	(	(	PUNCT
admet-2774	110	15	fpf	fpf	NOUN
admet-2774	110	16	≤5	≤5	VERB
admet-2774	110	17	μm	μm	NUM
admet-2774	110	18	)	)	PUNCT
admet-2774	110	19	,	,	PUNCT
admet-2774	110	20	mass	mass	ADJ
admet-2774	110	21	median	median	ADJ
admet-2774	110	22	aerodynamic	aerodynamic	ADJ
admet-2774	110	23	diameter	diameter	NOUN
admet-2774	110	24	(	(	PUNCT
admet-2774	110	25	mmad	mmad	NOUN
admet-2774	110	26	)	)	PUNCT
admet-2774	110	27	,	,	PUNCT
admet-2774	110	28	and	and	CCONJ
admet-2774	110	29	geometric	geometric	ADJ
admet-2774	110	30	standard	standard	ADJ
admet-2774	110	31	deviation	deviation	NOUN
admet-2774	110	32	(	(	PUNCT
admet-2774	110	33	gsd	gsd	NOUN
admet-2774	110	34	)	)	PUNCT
admet-2774	111	1	[	[	X
admet-2774	111	2	40	40	NUM
admet-2774	111	3	]	]	PUNCT
admet-2774	111	4	.	.	PUNCT
admet-2774	112	1	experiments	experiment	NOUN
admet-2774	112	2	were	be	AUX
admet-2774	112	3	executed	execute	VERB
admet-2774	112	4	in	in	ADP
admet-2774	112	5	triplicate	triplicate	NOUN
admet-2774	112	6	(	(	PUNCT
admet-2774	112	7	n	n	NOUN
admet-2774	112	8	=	=	SYM
admet-2774	112	9	3	3	NUM
admet-2774	112	10	)	)	PUNCT
admet-2774	112	11	to	to	PART
admet-2774	112	12	confirm	confirm	VERB
admet-2774	112	13	reproducibility	reproducibility	NOUN
admet-2774	112	14	.	.	PUNCT
admet-2774	113	1	in	in	ADP
admet-2774	113	2	vitro	vitro	X
admet-2774	113	3	drug	drug	NOUN
admet-2774	113	4	release	release	NOUN
admet-2774	113	5	pure	pure	ADJ
admet-2774	113	6	nh	nh	PROPN
admet-2774	113	7	and	and	CCONJ
admet-2774	113	8	inh	inh	PROPN
admet-2774	113	9	-	-	PUNCT
admet-2774	113	10	loaded	load	VERB
admet-2774	113	11	pcl	pcl	PROPN
admet-2774	113	12	nanoparticle	nanoparticle	NOUN
admet-2774	113	13	release	release	NOUN
admet-2774	113	14	profiles	profile	NOUN
admet-2774	113	15	were	be	AUX
admet-2774	113	16	evaluated	evaluate	VERB
admet-2774	113	17	under	under	ADP
admet-2774	113	18	sink	sink	NOUN
admet-2774	113	19	conditions	condition	NOUN
admet-2774	113	20	using	use	VERB
admet-2774	113	21	a	a	DET
admet-2774	113	22	dialysis	dialysis	NOUN
admet-2774	113	23	bag	bag	NOUN
admet-2774	113	24	method	method	NOUN
admet-2774	113	25	(	(	PUNCT
admet-2774	113	26	mwco	mwco	NOUN
admet-2774	113	27	:	:	PUNCT
admet-2774	113	28	12	12	NUM
admet-2774	113	29	-	-	SYM
admet-2774	113	30	14	14	NUM
admet-2774	113	31	kda	kda	NOUN
admet-2774	113	32	,	,	PUNCT
admet-2774	113	33	sigma	sigma	PROPN
admet-2774	113	34	-	-	PUNCT
admet-2774	113	35	aldrich	aldrich	NOUN
admet-2774	113	36	)	)	PUNCT
admet-2774	113	37	.	.	PUNCT
admet-2774	114	1	samples	sample	NOUN
admet-2774	114	2	(	(	PUNCT
admet-2774	114	3	2	2	NUM
admet-2774	114	4	ml	ml	NOUN
admet-2774	114	5	containing	contain	VERB
admet-2774	114	6	50	50	NUM
admet-2774	114	7	mg	mg	NOUN
admet-2774	114	8	of	of	ADP
admet-2774	114	9	drug	drug	NOUN
admet-2774	114	10	or	or	CCONJ
admet-2774	114	11	formulation	formulation	NOUN
admet-2774	114	12	)	)	PUNCT
admet-2774	114	13	were	be	AUX
admet-2774	114	14	sealed	seal	VERB
admet-2774	114	15	in	in	ADP
admet-2774	114	16	dialysis	dialysis	NOUN
admet-2774	114	17	bags	bag	NOUN
admet-2774	114	18	and	and	CCONJ
admet-2774	114	19	immersed	immerse	VERB
admet-2774	114	20	in	in	ADP
admet-2774	114	21	900	900	NUM
admet-2774	114	22	ml	ml	NOUN
admet-2774	114	23	of	of	ADP
admet-2774	114	24	phosphate	phosphate	NOUN
admet-2774	114	25	-	-	PUNCT
admet-2774	114	26	buffered	buffer	VERB
admet-2774	114	27	saline	saline	NOUN
admet-2774	114	28	(	(	PUNCT
admet-2774	114	29	pbs	pbs	PROPN
admet-2774	114	30	,	,	PUNCT
admet-2774	114	31	ph	ph	X
admet-2774	114	32	7.4	7.4	NUM
admet-2774	114	33	)	)	PUNCT
admet-2774	114	34	maintained	maintain	VERB
admet-2774	114	35	at	at	ADP
admet-2774	114	36	37.5	37.5	NUM
admet-2774	114	37	±	±	NUM
admet-2774	114	38	0.5	0.5	NUM
admet-2774	114	39	°	°	ADP
admet-2774	114	40	c	c	NOUN
admet-2774	114	41	with	with	ADP
admet-2774	114	42	continuous	continuous	ADJ
admet-2774	114	43	agitation	agitation	NOUN
admet-2774	114	44	(	(	PUNCT
admet-2774	114	45	50	50	NUM
admet-2774	114	46	rpm	rpm	NOUN
admet-2774	114	47	)	)	PUNCT
admet-2774	114	48	.	.	PUNCT
admet-2774	115	1	5	5	NUM
admet-2774	115	2	ml	ml	NOUN
admet-2774	115	3	aliquots	aliquot	NOUN
admet-2774	115	4	were	be	AUX
admet-2774	115	5	withdrawn	withdraw	VERB
admet-2774	115	6	and	and	CCONJ
admet-2774	115	7	replaced	replace	VERB
admet-2774	115	8	at	at	ADP
admet-2774	115	9	predetermined	predetermine	VERB
admet-2774	115	10	intervals	interval	NOUN
admet-2774	115	11	with	with	ADP
admet-2774	115	12	fresh	fresh	ADJ
admet-2774	115	13	pbs	pbs	NOUN
admet-2774	115	14	to	to	PART
admet-2774	115	15	preserve	preserve	VERB
admet-2774	115	16	sink	sink	NOUN
admet-2774	115	17	conditions	condition	NOUN
admet-2774	115	18	[	[	X
admet-2774	115	19	41,42	41,42	NOUN
admet-2774	115	20	]	]	PUNCT
admet-2774	115	21	.	.	PUNCT
admet-2774	116	1	the	the	DET
admet-2774	116	2	collected	collect	VERB
admet-2774	116	3	samples	sample	NOUN
admet-2774	116	4	were	be	AUX
admet-2774	116	5	filtered	filter	VERB
admet-2774	116	6	(	(	PUNCT
admet-2774	116	7	0.2	0.2	NUM
admet-2774	116	8	µm	µm	ADP
admet-2774	116	9	pvdf	pvdf	PROPN
admet-2774	116	10	syringe	syringe	NOUN
admet-2774	116	11	filters	filter	NOUN
admet-2774	116	12	)	)	PUNCT
admet-2774	116	13	to	to	PART
admet-2774	116	14	remove	remove	VERB
admet-2774	116	15	particulates	particulate	NOUN
admet-2774	116	16	,	,	PUNCT
admet-2774	116	17	and	and	CCONJ
admet-2774	116	18	the	the	DET
admet-2774	116	19	filtrates	filtrate	NOUN
admet-2774	116	20	were	be	AUX
admet-2774	116	21	analysed	analyse	VERB
admet-2774	116	22	for	for	ADP
admet-2774	116	23	inh	inh	PROPN
admet-2774	116	24	concentration	concentration	NOUN
admet-2774	116	25	via	via	ADP
admet-2774	116	26	uv	uv	NOUN
admet-2774	116	27	-	-	PUNCT
admet-2774	116	28	vis	vis	X
admet-2774	116	29	spectrophotometry	spectrophotometry	NOUN
admet-2774	116	30	(	(	PUNCT
admet-2774	116	31	λ	λ	X
admet-2774	116	32	=	=	NOUN
admet-2774	116	33	262	262	NUM
admet-2774	116	34	nm	nm	NOUN
admet-2774	116	35	)	)	PUNCT
admet-2774	116	36	.	.	PUNCT
admet-2774	117	1	all	all	DET
admet-2774	117	2	experiments	experiment	NOUN
admet-2774	117	3	were	be	AUX
admet-2774	117	4	performed	perform	VERB
admet-2774	117	5	in	in	ADP
admet-2774	117	6	triplicate	triplicate	PROPN
admet-2774	117	7	(	(	PUNCT
admet-2774	117	8	n	n	NOUN
admet-2774	117	9	=	=	SYM
admet-2774	117	10	3	3	NUM
admet-2774	117	11	)	)	PUNCT
admet-2774	117	12	,	,	PUNCT
admet-2774	117	13	with	with	ADP
admet-2774	117	14	mean	mean	ADJ
admet-2774	117	15	values	value	NOUN
admet-2774	117	16	reported	report	VERB
admet-2774	117	17	.	.	PUNCT
admet-2774	118	1	stability	stability	NOUN
admet-2774	118	2	study	study	VERB
admet-2774	118	3	the	the	DET
admet-2774	118	4	stability	stability	NOUN
admet-2774	118	5	of	of	ADP
admet-2774	118	6	inh	inh	PROPN
admet-2774	118	7	-	-	PUNCT
admet-2774	118	8	pcl	pcl	PROPN
admet-2774	118	9	nanoparticles	nanoparticle	NOUN
admet-2774	118	10	was	be	AUX
admet-2774	118	11	evaluated	evaluate	VERB
admet-2774	118	12	over	over	ADP
admet-2774	118	13	6	6	NUM
admet-2774	118	14	months	month	NOUN
admet-2774	118	15	under	under	ADP
admet-2774	118	16	storage	storage	NOUN
admet-2774	118	17	conditions	condition	NOUN
admet-2774	118	18	at	at	ADP
admet-2774	118	19	25	25	NUM
admet-2774	118	20	°	°	NOUN
admet-2774	118	21	c	c	NOUN
admet-2774	118	22	.	.	PUNCT
admet-2774	119	1	formulations	formulation	NOUN
admet-2774	119	2	in	in	ADP
admet-2774	119	3	sealed	seal	VERB
admet-2774	119	4	amber	amber	PROPN
admet-2774	119	5	vials	vial	NOUN
admet-2774	119	6	were	be	AUX
admet-2774	119	7	monitored	monitor	VERB
admet-2774	119	8	monthly	monthly	ADV
admet-2774	119	9	for	for	ADP
admet-2774	119	10	particle	particle	NOUN
admet-2774	119	11	size	size	NOUN
admet-2774	119	12	,	,	PUNCT
admet-2774	119	13	pdi	pdi	NOUN
admet-2774	119	14	and	and	CCONJ
admet-2774	119	15	zeta	zeta	NOUN
admet-2774	119	16	potential	potential	ADJ
admet-2774	119	17	changes	change	NOUN
admet-2774	119	18	to	to	PART
admet-2774	119	19	assess	assess	VERB
admet-2774	119	20	physicochemical	physicochemical	ADJ
admet-2774	119	21	stability[43	stability[43	NOUN
admet-2774	119	22	]	]	PUNCT
admet-2774	119	23	.	.	PUNCT
admet-2774	120	1	statistical	statistical	ADJ
admet-2774	120	2	analysis	analysis	NOUN
admet-2774	120	3	experimental	experimental	ADJ
admet-2774	120	4	results	result	NOUN
admet-2774	120	5	are	be	AUX
admet-2774	120	6	presented	present	VERB
admet-2774	120	7	as	as	ADP
admet-2774	120	8	mean	mean	NOUN
admet-2774	120	9	±	±	NUM
admet-2774	120	10	standard	standard	ADJ
admet-2774	120	11	deviation	deviation	NOUN
admet-2774	120	12	(	(	PUNCT
admet-2774	120	13	sd	sd	NOUN
admet-2774	120	14	)	)	PUNCT
admet-2774	120	15	from	from	ADP
admet-2774	120	16	triplicate	triplicate	VERB
admet-2774	120	17	independent	independent	ADJ
admet-2774	120	18	measurements	measurement	NOUN
admet-2774	120	19	.	.	PUNCT
admet-2774	121	1	statistical	statistical	ADJ
admet-2774	121	2	significance	significance	NOUN
admet-2774	121	3	(	(	PUNCT
admet-2774	121	4	*	*	PUNCT
admet-2774	121	5	p<0.05	p<0.05	NOUN
admet-2774	121	6	,	,	PUNCT
admet-2774	121	7	*	*	PUNCT
admet-2774	121	8	*	*	PUNCT
admet-2774	121	9	p<0.01	p<0.01	PROPN
admet-2774	121	10	,	,	PUNCT
admet-2774	121	11	*	*	PUNCT
admet-2774	121	12	*	*	PUNCT
admet-2774	121	13	*	*	PUNCT
admet-2774	121	14	p<0.001	p<0.001	X
admet-2774	121	15	)	)	PUNCT
admet-2774	121	16	was	be	AUX
admet-2774	121	17	determined	determine	VERB
admet-2774	121	18	by	by	ADP
admet-2774	121	19	one	one	NUM
admet-2774	121	20	-	-	PUNCT
admet-2774	121	21	way	way	NOUN
admet-2774	121	22	anova	anova	X
admet-2774	121	23	using	use	VERB
admet-2774	121	24	originpro	originpro	PROPN
admet-2774	121	25	10.1	10.1	NUM
admet-2774	121	26	(	(	PUNCT
admet-2774	121	27	originlab	originlab	ADJ
admet-2774	121	28	,	,	PUNCT
admet-2774	121	29	https://www.originlab.com/	https://www.originlab.com/	NOUN
admet-2774	121	30	)	)	PUNCT
admet-2774	121	31	.	.	PUNCT
admet-2774	122	1	results	result	NOUN
admet-2774	122	2	and	and	CCONJ
admet-2774	122	3	discussion	discussion	NOUN
admet-2774	122	4	this	this	DET
admet-2774	122	5	study	study	NOUN
admet-2774	122	6	focused	focus	VERB
admet-2774	122	7	on	on	ADP
admet-2774	122	8	developing	develop	VERB
admet-2774	122	9	isoniazid	isoniazid	NOUN
admet-2774	122	10	-	-	PUNCT
admet-2774	122	11	loaded	load	VERB
admet-2774	122	12	poly(ε	poly(ε	NOUN
admet-2774	122	13	-	-	PUNCT
admet-2774	122	14	caprolactone	caprolactone	NOUN
admet-2774	122	15	)	)	PUNCT
admet-2774	122	16	nanoparticles	nanoparticle	NOUN
admet-2774	122	17	for	for	ADP
admet-2774	122	18	sustained	sustained	ADJ
admet-2774	122	19	drug	drug	NOUN
admet-2774	122	20	release	release	NOUN
admet-2774	122	21	.	.	PUNCT
admet-2774	123	1	the	the	DET
admet-2774	123	2	nanoparticles	nanoparticle	NOUN
admet-2774	123	3	were	be	AUX
admet-2774	123	4	thoroughly	thoroughly	ADV
admet-2774	123	5	characterized	characterize	VERB
admet-2774	123	6	,	,	PUNCT
admet-2774	123	7	and	and	CCONJ
admet-2774	123	8	a	a	DET
admet-2774	123	9	design	design	NOUN
admet-2774	123	10	of	of	ADP
admet-2774	123	11	experiments	experiment	NOUN
admet-2774	123	12	methodology	methodology	NOUN
admet-2774	123	13	was	be	AUX
admet-2774	123	14	employed	employ	VERB
admet-2774	123	15	to	to	PART
admet-2774	123	16	optimize	optimize	VERB
admet-2774	123	17	formulation	formulation	NOUN
admet-2774	123	18	parameters	parameter	NOUN
admet-2774	123	19	,	,	PUNCT
admet-2774	123	20	with	with	ADP
admet-2774	123	21	particular	particular	ADJ
admet-2774	123	22	emphasis	emphasis	NOUN
admet-2774	123	23	on	on	ADP
admet-2774	123	24	controlling	control	VERB
admet-2774	123	25	particle	particle	NOUN
admet-2774	123	26	size	size	NOUN
admet-2774	123	27	and	and	CCONJ
admet-2774	123	28	maximizing	maximize	VERB
admet-2774	123	29	drug	drug	NOUN
admet-2774	123	30	encapsulation	encapsulation	NOUN
admet-2774	123	31	efficiency	efficiency	NOUN
admet-2774	123	32	.	.	PUNCT
admet-2774	124	1	optimization	optimization	NOUN
admet-2774	124	2	of	of	ADP
admet-2774	124	3	nanoparticles	nanoparticle	NOUN
admet-2774	124	4	bbd	bbd	PROPN
admet-2774	124	5	was	be	AUX
admet-2774	124	6	used	use	VERB
admet-2774	124	7	to	to	PART
admet-2774	124	8	determine	determine	VERB
admet-2774	124	9	the	the	DET
admet-2774	124	10	effect	effect	NOUN
admet-2774	124	11	of	of	ADP
admet-2774	124	12	the	the	DET
admet-2774	124	13	independent	independent	ADJ
admet-2774	124	14	variable	variable	NOUN
admet-2774	124	15	on	on	ADP
admet-2774	124	16	the	the	DET
admet-2774	124	17	dependent	dependent	ADJ
admet-2774	124	18	variables	variable	NOUN
admet-2774	124	19	.	.	PUNCT
admet-2774	125	1	the	the	DET
admet-2774	125	2	concentration	concentration	NOUN
admet-2774	125	3	of	of	ADP
admet-2774	125	4	polymers	polymer	NOUN
admet-2774	125	5	(	(	PUNCT
admet-2774	125	6	pcl	pcl	PROPN
admet-2774	125	7	,	,	PUNCT
admet-2774	125	8	poloxamer	poloxamer	NOUN
admet-2774	125	9	188	188	NUM
admet-2774	125	10	)	)	PUNCT
admet-2774	125	11	and	and	CCONJ
admet-2774	125	12	stabilizer	stabilizer	NOUN
admet-2774	125	13	percentage	percentage	NOUN
admet-2774	125	14	(	(	PUNCT
admet-2774	125	15	tween	tween	NOUN
admet-2774	125	16	80	80	NUM
admet-2774	125	17	)	)	PUNCT
admet-2774	125	18	were	be	AUX
admet-2774	125	19	selected	select	VERB
admet-2774	125	20	as	as	ADP
admet-2774	125	21	independent	independent	ADJ
admet-2774	125	22	variables	variable	NOUN
admet-2774	125	23	.	.	PUNCT
admet-2774	126	1	the	the	DET
admet-2774	126	2	dependent	dependent	ADJ
admet-2774	126	3	variables	variable	NOUN
admet-2774	126	4	were	be	AUX
admet-2774	126	5	the	the	DET
admet-2774	126	6	particle	particle	NOUN
admet-2774	126	7	size	size	NOUN
admet-2774	126	8	,	,	PUNCT
admet-2774	126	9	pdi	pdi	NOUN
admet-2774	126	10	,	,	PUNCT
admet-2774	126	11	and	and	CCONJ
admet-2774	126	12	surface	surface	NOUN
admet-2774	126	13	charge	charge	NOUN
admet-2774	126	14	.	.	PUNCT
admet-2774	127	1	the	the	DET
admet-2774	127	2	effect	effect	NOUN
admet-2774	127	3	of	of	ADP
admet-2774	127	4	an	an	DET
admet-2774	127	5	independent	independent	ADJ
admet-2774	127	6	variable	variable	NOUN
admet-2774	127	7	on	on	ADP
admet-2774	127	8	the	the	DET
admet-2774	127	9	dependent	dependent	ADJ
admet-2774	127	10	variables	variable	NOUN
admet-2774	127	11	was	be	AUX
admet-2774	127	12	analysed	analyse	VERB
admet-2774	127	13	by	by	ADP
admet-2774	127	14	constructing	construct	VERB
admet-2774	127	15	polynomial	polynomial	ADJ
admet-2774	127	16	equations	equation	NOUN
admet-2774	127	17	and	and	CCONJ
admet-2774	127	18	counterplots	counterplot	NOUN
admet-2774	127	19	.	.	PUNCT
admet-2774	128	1	the	the	DET
admet-2774	128	2	obtained	obtain	VERB
admet-2774	128	3	polynomial	polynomial	ADJ
admet-2774	128	4	equations	equation	NOUN
admet-2774	128	5	(	(	PUNCT
admet-2774	128	6	3	3	X
admet-2774	128	7	)	)	PUNCT
admet-2774	128	8	to	to	ADP
admet-2774	128	9	(	(	PUNCT
admet-2774	128	10	5	5	NUM
admet-2774	128	11	)	)	PUNCT
admet-2774	128	12	for	for	ADP
admet-2774	128	13	the	the	DET
admet-2774	128	14	responses	response	NOUN
admet-2774	128	15	particle	particle	NOUN
admet-2774	128	16	size	size	NOUN
admet-2774	128	17	(	(	PUNCT
admet-2774	128	18	y1	y1	NOUN
admet-2774	128	19	)	)	PUNCT
admet-2774	128	20	,	,	PUNCT
admet-2774	128	21	pdi	pdi	PROPN
admet-2774	128	22	(	(	PUNCT
admet-2774	128	23	y2	y2	PROPN
admet-2774	128	24	)	)	PUNCT
admet-2774	128	25	and	and	CCONJ
admet-2774	128	26	surface	surface	NOUN
admet-2774	128	27	charge	charge	NOUN
admet-2774	128	28	(	(	PUNCT
admet-2774	128	29	y3	y3	NOUN
admet-2774	128	30	)	)	PUNCT
admet-2774	128	31	are	be	AUX
admet-2774	128	32	as	as	SCONJ
admet-2774	128	33	follows	follow	VERB
admet-2774	128	34	:	:	PUNCT
admet-2774	128	35	https://www.originlab.com/	https://www.originlab.com/	NOUN
admet-2774	128	36	admet	admet	PROPN
admet-2774	128	37	&	&	CCONJ
admet-2774	128	38	dmpk	dmpk	PROPN
admet-2774	128	39	13(4	13(4	NUM
admet-2774	128	40	)	)	PUNCT
admet-2774	128	41	(	(	PUNCT
admet-2774	128	42	2025	2025	NUM
admet-2774	128	43	)	)	PUNCT
admet-2774	128	44	2774	2774	NUM
admet-2774	128	45	freeze	freeze	NOUN
admet-2774	128	46	-	-	PUNCT
admet-2774	128	47	dried	dry	VERB
admet-2774	128	48	isoniazid	isoniazid	NOUN
admet-2774	128	49	-	-	PUNCT
admet-2774	128	50	loaded	load	VERB
admet-2774	128	51	poly	poly	ADJ
admet-2774	128	52	-	-	PUNCT
admet-2774	128	53	ε	ε	NOUN
admet-2774	128	54	-	-	PUNCT
admet-2774	128	55	caprolactone	caprolactone	ADJ
admet-2774	128	56	nanoparticles	nanoparticle	NOUN
admet-2774	128	57	doi	doi	NOUN
admet-2774	128	58	:	:	PUNCT
admet-2774	128	59	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	128	60	7	7	NUM
admet-2774	128	61	y1	y1	NOUN
admet-2774	128	62	=	=	VERB
admet-2774	128	63	172.46	172.46	NUM
admet-2774	128	64	-8.7375x1	-8.7375x1	NOUN
admet-2774	128	65	+	+	NUM
admet-2774	128	66	11.515x2	11.515x2	NUM
admet-2774	128	67	0.6475x3	0.6475x3	NUM
admet-2774	128	68	+	+	CCONJ
admet-2774	128	69	33.575x1x2	33.575x1x2	NUM
admet-2774	128	70	+	+	CCONJ
admet-2774	128	71	-52.58x2x3	-52.58x2x3	NOUN
admet-2774	128	72	+	+	CCONJ
admet-2774	128	73	5.5475x1	5.5475x1	NUM
admet-2774	128	74	2	2	NUM
admet-2774	128	75	+	+	CCONJ
admet-2774	128	76	+	+	CCONJ
admet-2774	128	77	46.8175x2	46.8175x2	NUM
admet-2774	128	78	2	2	NUM
admet-2774	128	79	+	+	NUM
admet-2774	128	80	22.5925x3	22.5925x3	NUM
admet-2774	128	81	2	2	NUM
admet-2774	128	82	(	(	PUNCT
admet-2774	128	83	3	3	NUM
admet-2774	128	84	)	)	PUNCT
admet-2774	128	85	y2	y2	NOUN
admet-2774	128	86	=	=	SYM
admet-2774	128	87	0.164882	0.164882	NUM
admet-2774	128	88	-0.016125x1	-0.016125x1	NUM
admet-2774	128	89	+	+	CCONJ
admet-2774	128	90	0.0105x2	0.0105x2	NUM
admet-2774	128	91	-0.076375x3	-0.076375x3	PUNCT
admet-2774	128	92	(	(	PUNCT
admet-2774	128	93	4	4	X
admet-2774	128	94	)	)	PUNCT
admet-2774	128	95	y3	y3	NOUN
admet-2774	128	96	=	=	SYM
admet-2774	128	97	-18.1871	-18.1871	PUNCT
admet-2774	128	98	+	+	NUM
admet-2774	128	99	1.16375x1	1.16375x1	NUM
admet-2774	128	100	3.59125x2	3.59125x2	NUM
admet-2774	128	101	+	+	NUM
admet-2774	128	102	0.6475x3	0.6475x3	NUM
admet-2774	128	103	(	(	PUNCT
admet-2774	128	104	5	5	NUM
admet-2774	128	105	)	)	PUNCT
admet-2774	128	106	as	as	ADP
admet-2774	128	107	the	the	DET
admet-2774	128	108	above	above	ADJ
admet-2774	128	109	equations	equation	NOUN
admet-2774	128	110	state	state	PROPN
admet-2774	128	111	,	,	PUNCT
admet-2774	128	112	the	the	DET
admet-2774	128	113	positive	positive	ADJ
admet-2774	128	114	sign	sign	NOUN
admet-2774	128	115	indicates	indicate	VERB
admet-2774	128	116	the	the	DET
admet-2774	128	117	independent	independent	ADJ
admet-2774	128	118	variable	variable	NOUN
admet-2774	128	119	's	's	PART
admet-2774	128	120	synergic	synergic	ADJ
admet-2774	128	121	effect	effect	NOUN
admet-2774	128	122	,	,	PUNCT
admet-2774	128	123	whereas	whereas	SCONJ
admet-2774	128	124	a	a	DET
admet-2774	128	125	negative	negative	ADJ
admet-2774	128	126	sign	sign	NOUN
admet-2774	128	127	indicates	indicate	VERB
admet-2774	128	128	the	the	DET
admet-2774	128	129	antagonistic	antagonistic	ADJ
admet-2774	128	130	effect	effect	NOUN
admet-2774	128	131	.	.	PUNCT
admet-2774	129	1	the	the	DET
admet-2774	129	2	polynomial	polynomial	ADJ
admet-2774	129	3	equations	equation	NOUN
admet-2774	129	4	and	and	CCONJ
admet-2774	129	5	statistical	statistical	ADJ
admet-2774	129	6	analysis	analysis	NOUN
admet-2774	129	7	reveal	reveal	VERB
admet-2774	129	8	a	a	DET
admet-2774	129	9	distinct	distinct	ADJ
admet-2774	129	10	relationship	relationship	NOUN
admet-2774	129	11	between	between	ADP
admet-2774	129	12	the	the	DET
admet-2774	129	13	formulation	formulation	NOUN
admet-2774	129	14	variable	variable	NOUN
admet-2774	129	15	and	and	CCONJ
admet-2774	129	16	nanoparticle	nanoparticle	NOUN
admet-2774	129	17	properties	property	NOUN
admet-2774	129	18	.	.	PUNCT
admet-2774	130	1	equation	equation	NOUN
admet-2774	130	2	(	(	PUNCT
admet-2774	130	3	3	3	NUM
admet-2774	130	4	)	)	PUNCT
admet-2774	130	5	(	(	PUNCT
admet-2774	130	6	particle	particle	NOUN
admet-2774	130	7	size	size	NOUN
admet-2774	130	8	)	)	PUNCT
admet-2774	130	9	exhibited	exhibit	VERB
admet-2774	130	10	synergistic	synergistic	ADJ
admet-2774	130	11	and	and	CCONJ
admet-2774	130	12	antagonistic	antagonistic	ADJ
admet-2774	130	13	effects	effect	NOUN
admet-2774	130	14	of	of	ADP
admet-2774	130	15	the	the	DET
admet-2774	130	16	independent	independent	ADJ
admet-2774	130	17	variables	variable	NOUN
admet-2774	130	18	.	.	PUNCT
admet-2774	131	1	the	the	DET
admet-2774	131	2	negative	negative	ADJ
admet-2774	131	3	coefficient	coefficient	NOUN
admet-2774	131	4	of	of	ADP
admet-2774	131	5	x1	x1	PROPN
admet-2774	131	6	(	(	PUNCT
admet-2774	131	7	-8.7375	-8.7375	PROPN
admet-2774	131	8	)	)	PUNCT
admet-2774	131	9	suggests	suggest	VERB
admet-2774	131	10	an	an	DET
admet-2774	131	11	antagonistic	antagonistic	ADJ
admet-2774	131	12	effect	effect	NOUN
admet-2774	131	13	,	,	PUNCT
admet-2774	131	14	implying	imply	VERB
admet-2774	131	15	that	that	SCONJ
admet-2774	131	16	increased	increase	VERB
admet-2774	131	17	pcl	pcl	PROPN
admet-2774	131	18	concentration	concentration	NOUN
admet-2774	131	19	reduces	reduce	VERB
admet-2774	131	20	particle	particle	NOUN
admet-2774	131	21	size	size	NOUN
admet-2774	131	22	.	.	PUNCT
admet-2774	132	1	conversely	conversely	ADV
admet-2774	132	2	,	,	PUNCT
admet-2774	132	3	x2	x2	PROPN
admet-2774	132	4	concentration	concentration	NOUN
admet-2774	132	5	exhibited	exhibit	VERB
admet-2774	132	6	a	a	DET
admet-2774	132	7	synergistic	synergistic	ADJ
admet-2774	132	8	effect	effect	NOUN
admet-2774	132	9	,	,	PUNCT
admet-2774	132	10	which	which	PRON
admet-2774	132	11	increased	increase	VERB
admet-2774	132	12	particle	particle	NOUN
admet-2774	132	13	size	size	NOUN
admet-2774	132	14	,	,	PUNCT
admet-2774	132	15	while	while	SCONJ
admet-2774	132	16	x3	x3	ADJ
admet-2774	132	17	(	(	PUNCT
admet-2774	132	18	-0.6475	-0.6475	PROPN
admet-2774	132	19	)	)	PUNCT
admet-2774	132	20	had	have	VERB
admet-2774	132	21	a	a	DET
admet-2774	132	22	mild	mild	ADJ
admet-2774	132	23	antagonistic	antagonistic	ADJ
admet-2774	132	24	effect	effect	NOUN
admet-2774	132	25	.	.	PUNCT
admet-2774	133	1	a	a	DET
admet-2774	133	2	significant	significant	ADJ
admet-2774	133	3	interaction	interaction	NOUN
admet-2774	133	4	was	be	AUX
admet-2774	133	5	observed	observe	VERB
admet-2774	133	6	between	between	ADP
admet-2774	133	7	the	the	DET
admet-2774	133	8	x1x2	x1x2	X
admet-2774	133	9	(	(	PUNCT
admet-2774	133	10	+33.575	+33.575	ADJ
admet-2774	133	11	)	)	PUNCT
admet-2774	133	12	and	and	CCONJ
admet-2774	133	13	x2x3	x2x3	NUM
admet-2774	133	14	(	(	PUNCT
admet-2774	133	15	-52.58	-52.58	PROPN
admet-2774	133	16	)	)	PUNCT
admet-2774	133	17	,	,	PUNCT
admet-2774	133	18	indicating	indicate	VERB
admet-2774	133	19	complex	complex	ADJ
admet-2774	133	20	synergetic	synergetic	ADJ
admet-2774	133	21	and	and	CCONJ
admet-2774	133	22	antagonistic	antagonistic	ADJ
admet-2774	133	23	interdependencies	interdependency	NOUN
admet-2774	133	24	.	.	PUNCT
admet-2774	134	1	the	the	DET
admet-2774	134	2	optimized	optimize	VERB
admet-2774	134	3	formulation	formulation	NOUN
admet-2774	134	4	(	(	PUNCT
admet-2774	134	5	run	run	NOUN
admet-2774	134	6	10	10	NUM
admet-2774	134	7	)	)	PUNCT
admet-2774	134	8	resulted	result	VERB
admet-2774	134	9	in	in	ADP
admet-2774	134	10	a	a	DET
admet-2774	134	11	minimal	minimal	ADJ
admet-2774	134	12	average	average	ADJ
admet-2774	134	13	particle	particle	NOUN
admet-2774	134	14	size	size	NOUN
admet-2774	134	15	of	of	ADP
admet-2774	134	16	248.4±5.37	248.4±5.37	PROPN
admet-2774	134	17	nm	nm	PROPN
admet-2774	134	18	,	,	PUNCT
admet-2774	134	19	highlighting	highlight	VERB
admet-2774	134	20	the	the	DET
admet-2774	134	21	microreactor	microreactor	NOUN
admet-2774	134	22	-	-	PUNCT
admet-2774	134	23	assisted	assist	VERB
admet-2774	134	24	synthesis	synthesis	NOUN
admet-2774	134	25	's	's	PART
admet-2774	134	26	efficiency	efficiency	NOUN
admet-2774	134	27	.	.	PUNCT
admet-2774	135	1	in	in	ADP
admet-2774	135	2	equation	equation	NOUN
admet-2774	135	3	(	(	PUNCT
admet-2774	135	4	4	4	NUM
admet-2774	135	5	)	)	PUNCT
admet-2774	135	6	(	(	PUNCT
admet-2774	135	7	pdi	pdi	PROPN
admet-2774	135	8	)	)	PUNCT
admet-2774	135	9	,	,	PUNCT
admet-2774	135	10	all	all	DET
admet-2774	135	11	three	three	NUM
admet-2774	135	12	variables	variable	NOUN
admet-2774	135	13	exhibited	exhibit	VERB
admet-2774	135	14	antagonistic	antagonistic	ADJ
admet-2774	135	15	or	or	CCONJ
admet-2774	135	16	minimal	minimal	ADJ
admet-2774	135	17	effects	effect	NOUN
admet-2774	135	18	.	.	PUNCT
admet-2774	136	1	x1	x1	PROPN
admet-2774	136	2	(	(	PUNCT
admet-2774	136	3	-0.016125	-0.016125	NOUN
admet-2774	136	4	)	)	PUNCT
admet-2774	136	5	and	and	CCONJ
admet-2774	136	6	x3	x3	ADJ
admet-2774	136	7	(	(	PUNCT
admet-2774	136	8	-0.076375	-0.076375	PROPN
admet-2774	136	9	)	)	PUNCT
admet-2774	136	10	contributed	contribute	VERB
admet-2774	136	11	to	to	ADP
admet-2774	136	12	a	a	DET
admet-2774	136	13	decrease	decrease	NOUN
admet-2774	136	14	in	in	ADP
admet-2774	136	15	pdi	pdi	PROPN
admet-2774	136	16	,	,	PUNCT
admet-2774	136	17	implying	imply	VERB
admet-2774	136	18	improved	improved	ADJ
admet-2774	136	19	uniformity	uniformity	NOUN
admet-2774	136	20	,	,	PUNCT
admet-2774	136	21	while	while	SCONJ
admet-2774	136	22	x2	x2	PRON
admet-2774	136	23	(	(	PUNCT
admet-2774	136	24	+0.0105	+0.0105	NOUN
admet-2774	136	25	)	)	PUNCT
admet-2774	136	26	slightly	slightly	ADV
admet-2774	136	27	increased	increase	VERB
admet-2774	136	28	pdi	pdi	NOUN
admet-2774	136	29	.	.	PUNCT
admet-2774	137	1	the	the	DET
admet-2774	137	2	optimized	optimize	VERB
admet-2774	137	3	batch	batch	NOUN
admet-2774	137	4	(	(	PUNCT
admet-2774	137	5	run	run	VERB
admet-2774	137	6	10	10	NUM
admet-2774	137	7	)	)	PUNCT
admet-2774	137	8	demonstrated	demonstrate	VERB
admet-2774	137	9	a	a	DET
admet-2774	137	10	pdi	pdi	NOUN
admet-2774	137	11	of	of	ADP
admet-2774	137	12	0.067±0.011	0.067±0.011	NOUN
admet-2774	137	13	,	,	PUNCT
admet-2774	137	14	indicating	indicate	VERB
admet-2774	137	15	narrow	narrow	ADJ
admet-2774	137	16	size	size	NOUN
admet-2774	137	17	distributions	distribution	NOUN
admet-2774	137	18	and	and	CCONJ
admet-2774	137	19	good	good	ADJ
admet-2774	137	20	nanoparticle	nanoparticle	NOUN
admet-2774	137	21	homogeneity	homogeneity	NOUN
admet-2774	137	22	.	.	PUNCT
admet-2774	138	1	equation	equation	NOUN
admet-2774	138	2	(	(	PUNCT
admet-2774	138	3	5	5	NUM
admet-2774	138	4	)	)	PUNCT
admet-2774	138	5	(	(	PUNCT
admet-2774	138	6	surface	surface	NOUN
admet-2774	138	7	charge	charge	NOUN
admet-2774	138	8	)	)	PUNCT
admet-2774	138	9	showed	show	VERB
admet-2774	138	10	the	the	DET
admet-2774	138	11	synergetic	synergetic	ADJ
admet-2774	138	12	effect	effect	NOUN
admet-2774	138	13	of	of	ADP
admet-2774	138	14	x1	x1	PROPN
admet-2774	138	15	(	(	PUNCT
admet-2774	138	16	+1.16375	+1.16375	PROPN
admet-2774	138	17	)	)	PUNCT
admet-2774	138	18	,	,	PUNCT
admet-2774	138	19	increasing	increase	VERB
admet-2774	138	20	surface	surface	NOUN
admet-2774	138	21	charge	charge	NOUN
admet-2774	138	22	,	,	PUNCT
admet-2774	138	23	whereas	whereas	SCONJ
admet-2774	138	24	x2	x2	PROPN
admet-2774	138	25	(	(	PUNCT
admet-2774	138	26	-3.591250	-3.591250	PROPN
admet-2774	138	27	exhibited	exhibit	VERB
admet-2774	138	28	an	an	DET
admet-2774	138	29	antagonistic	antagonistic	ADJ
admet-2774	138	30	effect	effect	NOUN
admet-2774	138	31	,	,	PUNCT
admet-2774	138	32	and	and	CCONJ
admet-2774	138	33	x3	x3	ADJ
admet-2774	138	34	(	(	PUNCT
admet-2774	138	35	+0.6475	+0.6475	PROPN
admet-2774	138	36	)	)	PUNCT
admet-2774	138	37	showed	show	VERB
admet-2774	138	38	a	a	DET
admet-2774	138	39	mild	mild	ADJ
admet-2774	138	40	synergetic	synergetic	ADJ
admet-2774	138	41	impact	impact	NOUN
admet-2774	138	42	.	.	PUNCT
admet-2774	139	1	these	these	DET
admet-2774	139	2	effects	effect	NOUN
admet-2774	139	3	reflect	reflect	VERB
admet-2774	139	4	the	the	DET
admet-2774	139	5	electrostatic	electrostatic	ADJ
admet-2774	139	6	stability	stability	NOUN
admet-2774	139	7	of	of	ADP
admet-2774	139	8	nanoparticles	nanoparticle	NOUN
admet-2774	139	9	,	,	PUNCT
admet-2774	139	10	which	which	PRON
admet-2774	139	11	is	be	AUX
admet-2774	139	12	crucial	crucial	ADJ
admet-2774	139	13	for	for	ADP
admet-2774	139	14	maintaining	maintain	VERB
admet-2774	139	15	colloidal	colloidal	NOUN
admet-2774	139	16	dispersion	dispersion	NOUN
admet-2774	139	17	.	.	PUNCT
admet-2774	140	1	the	the	DET
admet-2774	140	2	optimized	optimize	VERB
admet-2774	140	3	batch	batch	NOUN
admet-2774	140	4	(	(	PUNCT
admet-2774	140	5	run	run	VERB
admet-2774	140	6	10	10	NUM
admet-2774	140	7	)	)	PUNCT
admet-2774	140	8	demonstrated	demonstrate	VERB
admet-2774	140	9	a	a	DET
admet-2774	140	10	surface	surface	NOUN
admet-2774	140	11	charge	charge	NOUN
admet-2774	140	12	of	of	ADP
admet-2774	140	13	-24.8	-24.8	PRON
admet-2774	140	14	±	±	PROPN
admet-2774	140	15	0.30	0.30	NUM
admet-2774	140	16	mv	mv	PROPN
admet-2774	140	17	,	,	PUNCT
admet-2774	140	18	indicating	indicate	VERB
admet-2774	140	19	acceptable	acceptable	ADJ
admet-2774	140	20	colloidal	colloidal	NOUN
admet-2774	140	21	stability	stability	NOUN
admet-2774	140	22	of	of	ADP
admet-2774	140	23	nanoparticles	nanoparticle	NOUN
admet-2774	140	24	.	.	PUNCT
admet-2774	141	1	the	the	DET
admet-2774	141	2	coefficient	coefficient	NOUN
admet-2774	141	3	of	of	ADP
admet-2774	141	4	determination	determination	NOUN
admet-2774	141	5	(	(	PUNCT
admet-2774	141	6	r²	r²	NOUN
admet-2774	141	7	)	)	PUNCT
admet-2774	141	8	values	value	NOUN
admet-2774	141	9	for	for	ADP
admet-2774	141	10	y₁	y₁	NOUN
admet-2774	141	11	,	,	PUNCT
admet-2774	141	12	y₂	y₂	NOUN
admet-2774	141	13	,	,	PUNCT
admet-2774	141	14	and	and	CCONJ
admet-2774	141	15	y₃	y₃	PROPN
admet-2774	141	16	were	be	AUX
admet-2774	141	17	0.6633	0.6633	NUM
admet-2774	141	18	,	,	PUNCT
admet-2774	141	19	0.3455	0.3455	NUM
admet-2774	141	20	,	,	PUNCT
admet-2774	141	21	and	and	CCONJ
admet-2774	141	22	0.3240	0.3240	NUM
admet-2774	141	23	,	,	PUNCT
admet-2774	141	24	respectively	respectively	ADV
admet-2774	141	25	.	.	PUNCT
admet-2774	142	1	these	these	DET
admet-2774	142	2	values	value	NOUN
admet-2774	142	3	suggest	suggest	VERB
admet-2774	142	4	a	a	DET
admet-2774	142	5	moderately	moderately	ADV
admet-2774	142	6	good	good	ADJ
admet-2774	142	7	fit	fit	NOUN
admet-2774	142	8	for	for	ADP
admet-2774	142	9	the	the	DET
admet-2774	142	10	particle	particle	NOUN
admet-2774	142	11	size	size	NOUN
admet-2774	142	12	model	model	NOUN
admet-2774	142	13	(	(	PUNCT
admet-2774	142	14	y₁	y₁	NOUN
admet-2774	142	15	)	)	PUNCT
admet-2774	142	16	and	and	CCONJ
admet-2774	142	17	lower	low	ADJ
admet-2774	142	18	predictive	predictive	ADJ
admet-2774	142	19	accuracy	accuracy	NOUN
admet-2774	142	20	for	for	ADP
admet-2774	142	21	pdi	pdi	PROPN
admet-2774	142	22	(	(	PUNCT
admet-2774	142	23	y₂	y₂	NOUN
admet-2774	142	24	)	)	PUNCT
admet-2774	142	25	and	and	CCONJ
admet-2774	142	26	surface	surface	NOUN
admet-2774	142	27	charge	charge	NOUN
admet-2774	142	28	(	(	PUNCT
admet-2774	142	29	y₃	y₃	PROPN
admet-2774	142	30	)	)	PUNCT
admet-2774	142	31	.	.	PUNCT
admet-2774	143	1	nonetheless	nonetheless	ADV
admet-2774	143	2	,	,	PUNCT
admet-2774	143	3	the	the	DET
admet-2774	143	4	p	p	NOUN
admet-2774	143	5	-	-	PUNCT
admet-2774	143	6	values	value	NOUN
admet-2774	143	7	of	of	ADP
admet-2774	143	8	0.0281	0.0281	NUM
admet-2774	143	9	(	(	PUNCT
admet-2774	143	10	y₁	y₁	NOUN
admet-2774	143	11	)	)	PUNCT
admet-2774	143	12	,	,	PUNCT
admet-2774	143	13	0.0368	0.0368	NUM
admet-2774	143	14	(	(	PUNCT
admet-2774	143	15	y₂	y₂	NOUN
admet-2774	143	16	)	)	PUNCT
admet-2774	143	17	,	,	PUNCT
admet-2774	143	18	and	and	CCONJ
admet-2774	143	19	0.0447	0.0447	NUM
admet-2774	143	20	(	(	PUNCT
admet-2774	143	21	y₃	y₃	PROPN
admet-2774	143	22	)	)	PUNCT
admet-2774	143	23	confirm	confirm	VERB
admet-2774	143	24	the	the	DET
admet-2774	143	25	statistical	statistical	ADJ
admet-2774	143	26	significance	significance	NOUN
admet-2774	143	27	of	of	ADP
admet-2774	143	28	the	the	DET
admet-2774	143	29	models	model	NOUN
admet-2774	143	30	at	at	ADP
admet-2774	143	31	the	the	DET
admet-2774	143	32	p	p	X
admet-2774	143	33	<	<	X
admet-2774	143	34	0.05	0.05	NUM
admet-2774	143	35	level	level	NOUN
admet-2774	143	36	(	(	PUNCT
admet-2774	143	37	table	table	NOUN
admet-2774	143	38	3	3	NUM
admet-2774	143	39	)	)	PUNCT
admet-2774	143	40	.	.	PUNCT
admet-2774	144	1	table	table	NOUN
admet-2774	145	1	3	3	NUM
admet-2774	145	2	.	.	PUNCT
admet-2774	146	1	statistical	statistical	ADJ
admet-2774	146	2	summary	summary	NOUN
admet-2774	146	3	of	of	ADP
admet-2774	146	4	the	the	DET
admet-2774	146	5	box	box	NOUN
admet-2774	146	6	-	-	PUNCT
admet-2774	146	7	behnken	behnken	VERB
admet-2774	146	8	design	design	NOUN
admet-2774	146	9	(	(	PUNCT
admet-2774	146	10	bbd	bbd	PROPN
admet-2774	146	11	)	)	PUNCT
admet-2774	146	12	model	model	NOUN
admet-2774	146	13	for	for	ADP
admet-2774	146	14	optimization	optimization	NOUN
admet-2774	146	15	of	of	ADP
admet-2774	146	16	inh	inh	PROPN
admet-2774	146	17	-	-	PUNCT
admet-2774	146	18	loaded	load	VERB
admet-2774	146	19	pcl	pcl	PROPN
admet-2774	146	20	nanoparticles	nanoparticle	NOUN
admet-2774	146	21	source	source	VERB
admet-2774	146	22	sequential	sequential	ADJ
admet-2774	146	23	p	p	ADJ
admet-2774	146	24	-	-	PUNCT
admet-2774	146	25	value	value	NOUN
admet-2774	146	26	lack	lack	NOUN
admet-2774	146	27	of	of	ADP
admet-2774	146	28	fit	fit	ADJ
admet-2774	146	29	p	p	NOUN
admet-2774	146	30	-	-	PUNCT
admet-2774	146	31	value	value	NOUN
admet-2774	146	32	adjusted	adjust	VERB
admet-2774	146	33	r²	r²	NOUN
admet-2774	146	34	predicted	predict	VERB
admet-2774	146	35	r²	r²	NOUN
admet-2774	146	36	particle	particle	NOUN
admet-2774	146	37	size	size	NOUN
admet-2774	146	38	linear	linear	PROPN
admet-2774	146	39	0.8804	0.8804	NUM
admet-2774	146	40	0.1199	0.1199	NUM
admet-2774	146	41	-0.1712	-0.1712	NOUN
admet-2774	146	42	-0.7151	-0.7151	NOUN
admet-2774	146	43	two	two	NUM
admet-2774	146	44	-	-	PUNCT
admet-2774	146	45	factor	factor	NOUN
admet-2774	146	46	interaction	interaction	NOUN
admet-2774	146	47	0.0823	0.0823	NUM
admet-2774	146	48	0.2021	0.2021	NUM
admet-2774	146	49	0.1975	0.1975	NUM
admet-2774	146	50	-0.4263	-0.4263	ADV
admet-2774	146	51	quadratic	quadratic	ADJ
admet-2774	146	52	(	(	PUNCT
admet-2774	146	53	suggested	suggest	VERB
admet-2774	146	54	)	)	PUNCT
admet-2774	146	55	0.0281	0.0281	NUM
admet-2774	146	56	0.7024	0.7024	NUM
admet-2774	146	57	0.6633	0.6633	NUM
admet-2774	146	58	0.1901	0.1901	NUM
admet-2774	146	59	cubic	cubic	ADJ
admet-2774	146	60	(	(	PUNCT
admet-2774	146	61	aliased	aliased	ADJ
admet-2774	146	62	)	)	PUNCT
admet-2774	146	63	0.7024	0.7024	NUM
admet-2774	146	64	0.5714	0.5714	NUM
admet-2774	146	65	pdi	pdi	NOUN
admet-2774	146	66	linear	linear	NOUN
admet-2774	146	67	(	(	PUNCT
admet-2774	146	68	suggested	suggest	VERB
admet-2774	146	69	)	)	PUNCT
admet-2774	146	70	0.0368	0.0368	NUM
admet-2774	147	1	0.9126	0.9126	NUM
admet-2774	147	2	0.3455	0.3455	NUM
admet-2774	147	3	0.1786	0.1786	NUM
admet-2774	147	4	two	two	NUM
admet-2774	147	5	-	-	PUNCT
admet-2774	147	6	factor	factor	NOUN
admet-2774	147	7	interaction	interaction	NOUN
admet-2774	147	8	0.6337	0.6337	NUM
admet-2774	147	9	0.8827	0.8827	NUM
admet-2774	147	10	0.2776	0.2776	NUM
admet-2774	147	11	-0.1068	-0.1068	ADJ
admet-2774	147	12	quadratic	quadratic	ADJ
admet-2774	147	13	0.4683	0.4683	NUM
admet-2774	147	14	0.9532	0.9532	NUM
admet-2774	147	15	0.2658	0.2658	NUM
admet-2774	147	16	0.1613	0.1613	NUM
admet-2774	147	17	cubic	cubic	ADJ
admet-2774	147	18	(	(	PUNCT
admet-2774	147	19	aliased	aliased	ADJ
admet-2774	147	20	)	)	PUNCT
admet-2774	147	21	0.9532	0.9532	NUM
admet-2774	147	22	-0.1916	-0.1916	X
admet-2774	147	23	zeta	zeta	NOUN
admet-2774	147	24	potential	potential	ADJ
admet-2774	147	25	linear	linear	PROPN
admet-2774	147	26	(	(	PUNCT
admet-2774	147	27	suggested	suggest	VERB
admet-2774	147	28	)	)	PUNCT
admet-2774	147	29	0.0447	0.0447	NUM
admet-2774	147	30	0.0653	0.0653	NUM
admet-2774	147	31	0.3240	0.3240	NUM
admet-2774	147	32	-0.1066	-0.1066	ADJ
admet-2774	147	33	two	two	NUM
admet-2774	147	34	-	-	PUNCT
admet-2774	147	35	factor	factor	NOUN
admet-2774	147	36	interaction	interaction	NOUN
admet-2774	147	37	0.1725	0.1725	NUM
admet-2774	147	38	0.0831	0.0831	NUM
admet-2774	147	39	0.4546	0.4546	NUM
admet-2774	147	40	-0.5720	-0.5720	NOUN
admet-2774	147	41	quadratic	quadratic	ADJ
admet-2774	147	42	0.9293	0.9293	NUM
admet-2774	147	43	0.0334	0.0334	NUM
admet-2774	147	44	0.2666	0.2666	NUM
admet-2774	147	45	-3.5006	-3.5006	ADJ
admet-2774	147	46	cubic	cubic	ADJ
admet-2774	147	47	(	(	PUNCT
admet-2774	147	48	aliased	aliased	ADJ
admet-2774	147	49	)	)	PUNCT
admet-2774	147	50	0.0334	0.0334	NUM
admet-2774	147	51	0.8245	0.8245	NUM
admet-2774	147	52	analysis	analysis	NOUN
admet-2774	147	53	of	of	ADP
admet-2774	147	54	variance	variance	NOUN
admet-2774	147	55	(	(	PUNCT
admet-2774	147	56	anova	anova	PROPN
admet-2774	147	57	)	)	PUNCT
admet-2774	147	58	results	result	NOUN
admet-2774	147	59	in	in	ADP
admet-2774	147	60	table	table	NOUN
admet-2774	147	61	4	4	NUM
admet-2774	147	62	further	far	ADV
admet-2774	147	63	validated	validate	VERB
admet-2774	147	64	model	model	NOUN
admet-2774	147	65	adequacy	adequacy	NOUN
admet-2774	147	66	.	.	PUNCT
admet-2774	148	1	the	the	DET
admet-2774	148	2	interaction	interaction	NOUN
admet-2774	148	3	terms	term	NOUN
admet-2774	148	4	were	be	AUX
admet-2774	148	5	statistically	statistically	ADV
admet-2774	148	6	significant	significant	ADJ
admet-2774	148	7	,	,	PUNCT
admet-2774	148	8	particularly	particularly	ADV
admet-2774	148	9	for	for	ADP
admet-2774	148	10	y₁	y₁	NOUN
admet-2774	148	11	(	(	PUNCT
admet-2774	148	12	p	p	X
admet-2774	148	13	<	<	X
admet-2774	148	14	0.0015	0.0015	NUM
admet-2774	148	15	)	)	PUNCT
admet-2774	148	16	,	,	PUNCT
admet-2774	148	17	with	with	ADP
admet-2774	148	18	an	an	DET
admet-2774	148	19	associated	associated	ADJ
admet-2774	148	20	f	f	NOUN
admet-2774	148	21	-	-	PUNCT
admet-2774	148	22	value	value	NOUN
admet-2774	148	23	of	of	ADP
admet-2774	148	24	0.4996	0.4996	NUM
admet-2774	148	25	.	.	PUNCT
admet-2774	149	1	the	the	DET
admet-2774	149	2	f	f	NOUN
admet-2774	149	3	-	-	PUNCT
admet-2774	149	4	values	value	NOUN
admet-2774	149	5	for	for	ADP
admet-2774	149	6	y₂	y₂	NOUN
admet-2774	149	7	and	and	CCONJ
admet-2774	149	8	y₃	y₃	PROPN
admet-2774	149	9	were	be	AUX
admet-2774	149	10	0.3489	0.3489	NUM
admet-2774	149	11	and	and	CCONJ
admet-2774	149	12	5.12	5.12	NUM
admet-2774	149	13	,	,	PUNCT
admet-2774	149	14	respectively	respectively	ADV
admet-2774	149	15	,	,	PUNCT
admet-2774	149	16	indicating	indicate	VERB
admet-2774	149	17	that	that	SCONJ
admet-2774	149	18	the	the	DET
admet-2774	149	19	model	model	NOUN
admet-2774	149	20	terms	term	NOUN
admet-2774	149	21	contribute	contribute	VERB
admet-2774	149	22	meaningfully	meaningfully	ADV
admet-2774	149	23	to	to	ADP
admet-2774	149	24	predicting	predict	VERB
admet-2774	149	25	response	response	NOUN
admet-2774	149	26	behaviour	behaviour	NOUN
admet-2774	149	27	.	.	PUNCT
admet-2774	150	1	the	the	DET
admet-2774	150	2	2d	2d	NUM
admet-2774	150	3	contour	contour	NOUN
admet-2774	150	4	plots	plot	NOUN
admet-2774	150	5	and	and	CCONJ
admet-2774	150	6	3d	3d	NUM
admet-2774	150	7	response	response	NOUN
admet-2774	150	8	surface	surface	NOUN
admet-2774	150	9	diagrams	diagram	NOUN
admet-2774	150	10	(	(	PUNCT
admet-2774	150	11	figures	figure	NOUN
admet-2774	150	12	1a-1c	1a-1c	NOUN
admet-2774	150	13	'	'	PUNCT
admet-2774	150	14	)	)	PUNCT
admet-2774	150	15	were	be	AUX
admet-2774	150	16	generated	generate	VERB
admet-2774	150	17	to	to	PART
admet-2774	150	18	elucidate	elucidate	VERB
admet-2774	150	19	the	the	DET
admet-2774	150	20	relationships	relationship	NOUN
admet-2774	150	21	between	between	ADP
admet-2774	150	22	variables	variable	NOUN
admet-2774	150	23	.	.	PUNCT
admet-2774	151	1	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	151	2	e.	e.	PROPN
admet-2774	151	3	kole	kole	PROPN
admet-2774	151	4	et	et	PROPN
admet-2774	151	5	al	al	PROPN
admet-2774	151	6	.	.	PROPN
admet-2774	151	7	admet	admet	PROPN
admet-2774	151	8	&	&	CCONJ
admet-2774	151	9	dmpk	dmpk	PROPN
admet-2774	151	10	13(4	13(4	NUM
admet-2774	151	11	)	)	PUNCT
admet-2774	151	12	(	(	PUNCT
admet-2774	151	13	2025	2025	NUM
admet-2774	151	14	)	)	PUNCT
admet-2774	151	15	2774	2774	NUM
admet-2774	151	16	8	8	NUM
admet-2774	151	17	table	table	NOUN
admet-2774	151	18	4	4	NUM
admet-2774	151	19	.	.	PUNCT
admet-2774	151	20	summary	summary	NOUN
admet-2774	151	21	of	of	ADP
admet-2774	151	22	anova	anova	PROPN
admet-2774	151	23	for	for	ADP
admet-2774	151	24	y1	y1	PROPN
admet-2774	151	25	,	,	PUNCT
admet-2774	151	26	y2	y2	NOUN
admet-2774	151	27	,	,	PUNCT
admet-2774	151	28	and	and	CCONJ
admet-2774	151	29	y3	y3	VERB
admet-2774	151	30	the	the	DET
admet-2774	151	31	response	response	NOUN
admet-2774	151	32	inh	inh	ADV
admet-2774	151	33	-	-	PUNCT
admet-2774	151	34	loaded	load	VERB
admet-2774	151	35	pcl	pcl	PROPN
admet-2774	151	36	nanoparticles	nanoparticle	NOUN
admet-2774	151	37	source	source	NOUN
admet-2774	151	38	degree	degree	NOUN
admet-2774	151	39	of	of	ADP
admet-2774	151	40	freedom	freedom	NOUN
admet-2774	151	41	f	f	NOUN
admet-2774	151	42	-	-	PUNCT
admet-2774	151	43	value	value	NOUN
admet-2774	151	44	p	p	NOUN
admet-2774	151	45	-	-	PUNCT
admet-2774	151	46	value	value	NOUN
admet-2774	151	47	particle	particle	NOUN
admet-2774	151	48	size	size	NOUN
admet-2774	151	49	(	(	PUNCT
admet-2774	151	50	y1	y1	NOUN
admet-2774	151	51	)	)	PUNCT
admet-2774	151	52	model	model	NOUN
admet-2774	151	53	9	9	NUM
admet-2774	151	54	4.50	4.50	NUM
admet-2774	151	55	0.0300	0.0300	NUM
admet-2774	151	56	significant	significant	ADJ
admet-2774	151	57	a	a	DET
admet-2774	151	58	:	:	PUNCT
admet-2774	151	59	amount	amount	NOUN
admet-2774	151	60	of	of	ADP
admet-2774	151	61	pcl	pcl	PROPN
admet-2774	152	1	1	1	NUM
admet-2774	152	2	0.8389	0.8389	NUM
admet-2774	152	3	0.3902	0.3902	NUM
admet-2774	152	4	b	b	NOUN
admet-2774	152	5	:	:	PUNCT
admet-2774	152	6	amount	amount	NOUN
admet-2774	152	7	of	of	ADP
admet-2774	152	8	poloxamer	poloxamer	NOUN
admet-2774	152	9	188	188	NUM
admet-2774	152	10	1	1	NUM
admet-2774	152	11	1.46	1.46	NUM
admet-2774	152	12	0.2666	0.2666	NUM
admet-2774	152	13	c	c	NOUN
admet-2774	152	14	:	:	PUNCT
admet-2774	152	15	amount	amount	NOUN
admet-2774	152	16	of	of	ADP
admet-2774	152	17	stabilizer	stabilizer	NOUN
admet-2774	152	18	1	1	NUM
admet-2774	152	19	0.0046	0.0046	NUM
admet-2774	152	20	0.9478	0.9478	NUM
admet-2774	152	21	ab	ab	PROPN
admet-2774	152	22	1	1	NUM
admet-2774	152	23	6.19	6.19	NUM
admet-2774	152	24	0.0417	0.0417	NUM
admet-2774	152	25	ac	ac	PROPN
admet-2774	152	26	1	1	NUM
admet-2774	152	27	0.0005	0.0005	NUM
admet-2774	152	28	0.9829	0.9829	NUM
admet-2774	152	29	bc	bc	PROPN
admet-2774	152	30	1	1	NUM
admet-2774	152	31	15.19	15.19	NUM
admet-2774	152	32	0.0059	0.0059	NUM
admet-2774	152	33	a²	a²	NOUN
admet-2774	152	34	1	1	NUM
admet-2774	152	35	0.1780	0.1780	NUM
admet-2774	152	36	0.6858	0.6858	NUM
admet-2774	152	37	b²	b²	NOUN
admet-2774	152	38	1	1	NUM
admet-2774	152	39	12.68	12.68	NUM
admet-2774	152	40	0.0092	0.0092	NUM
admet-2774	152	41	c²	c²	NOUN
admet-2774	152	42	1	1	NUM
admet-2774	152	43	2.95	2.95	NUM
admet-2774	152	44	0.1295	0.1295	NUM
admet-2774	152	45	lack	lack	NOUN
admet-2774	152	46	of	of	ADP
admet-2774	152	47	fit	fit	ADJ
admet-2774	152	48	3	3	NUM
admet-2774	152	49	0.4996	0.4996	NUM
admet-2774	152	50	0.7024	0.7024	NUM
admet-2774	152	51	not	not	PART
admet-2774	152	52	significant	significant	ADJ
admet-2774	152	53	model	model	NOUN
admet-2774	152	54	3	3	NUM
admet-2774	152	55	3.82	3.82	NUM
admet-2774	152	56	0.0368	0.0368	NUM
admet-2774	152	57	significant	significant	ADJ
admet-2774	152	58	pdi	pdi	NOUN
admet-2774	152	59	(	(	PUNCT
admet-2774	152	60	y2	y2	NOUN
admet-2774	152	61	)	)	PUNCT
admet-2774	152	62	a	a	DET
admet-2774	152	63	:	:	PUNCT
admet-2774	152	64	amount	amount	NOUN
admet-2774	152	65	of	of	ADP
admet-2774	152	66	pcl	pcl	PROPN
admet-2774	152	67	1	1	NUM
admet-2774	152	68	0.4797	0.4797	NUM
admet-2774	152	69	0.5007	0.5007	NUM
admet-2774	152	70	b	b	NOUN
admet-2774	152	71	:	:	PUNCT
admet-2774	152	72	amount	amount	NOUN
admet-2774	152	73	of	of	ADP
admet-2774	152	74	poloxamer	poloxamer	NOUN
admet-2774	152	75	188	188	NUM
admet-2774	152	76	1	1	NUM
admet-2774	152	77	0.2034	0.2034	NUM
admet-2774	152	78	0.6594	0.6594	NUM
admet-2774	152	79	c	c	NOUN
admet-2774	152	80	:	:	PUNCT
admet-2774	152	81	amount	amount	NOUN
admet-2774	152	82	of	of	ADP
admet-2774	152	83	stabilizer	stabilizer	NOUN
admet-2774	152	84	1	1	NUM
admet-2774	152	85	10.76	10.76	NUM
admet-2774	152	86	0.0060	0.0060	NUM
admet-2774	152	87	lack	lack	NOUN
admet-2774	152	88	of	of	ADP
admet-2774	152	89	fit	fit	ADJ
admet-2774	152	90	9	9	NUM
admet-2774	152	91	0.3489	0.3489	NUM
admet-2774	152	92	0.9126	0.9126	NUM
admet-2774	152	93	not	not	PART
admet-2774	152	94	significant	significant	ADJ
admet-2774	152	95	model	model	NOUN
admet-2774	152	96	3	3	NUM
admet-2774	152	97	3.56	3.56	NUM
admet-2774	152	98	0.0447	0.0447	NUM
admet-2774	152	99	significant	significant	ADJ
admet-2774	152	100	zeta	zeta	NOUN
admet-2774	152	101	potential	potential	NOUN
admet-2774	152	102	(	(	PUNCT
admet-2774	152	103	y3	y3	NOUN
admet-2774	152	104	)	)	PUNCT
admet-2774	152	105	a	a	DET
admet-2774	152	106	:	:	PUNCT
admet-2774	152	107	amount	amount	NOUN
admet-2774	152	108	of	of	ADP
admet-2774	152	109	pcl	pcl	PROPN
admet-2774	152	110	1	1	NUM
admet-2774	152	111	0.9848	0.9848	NUM
admet-2774	152	112	0.3391	0.3391	NUM
admet-2774	152	113	b	b	NOUN
admet-2774	152	114	:	:	PUNCT
admet-2774	152	115	amount	amount	NOUN
admet-2774	152	116	of	of	ADP
admet-2774	152	117	poloxamer	poloxamer	NOUN
admet-2774	152	118	188	188	NUM
admet-2774	152	119	1	1	NUM
admet-2774	152	120	9.38	9.38	NUM
admet-2774	152	121	0.0091	0.0091	NUM
admet-2774	152	122	c	c	NOUN
admet-2774	152	123	:	:	PUNCT
admet-2774	152	124	amount	amount	NOUN
admet-2774	152	125	of	of	ADP
admet-2774	152	126	stabilizer	stabilizer	NOUN
admet-2774	152	127	1	1	NUM
admet-2774	152	128	0.3049	0.3049	NUM
admet-2774	152	129	0.5902	0.5902	NUM
admet-2774	152	130	lack	lack	NOUN
admet-2774	152	131	of	of	ADP
admet-2774	152	132	fit	fit	ADJ
admet-2774	152	133	9	9	NUM
admet-2774	152	134	5.12	5.12	NUM
admet-2774	152	135	0.0653	0.0653	NUM
admet-2774	152	136	not	not	PART
admet-2774	152	137	significant	significant	ADJ
admet-2774	152	138	figure	figure	NOUN
admet-2774	152	139	1	1	NUM
admet-2774	152	140	.	.	PUNCT
admet-2774	152	141	response	response	NOUN
admet-2774	152	142	surface	surface	NOUN
admet-2774	152	143	methodology	methodology	NOUN
admet-2774	152	144	(	(	PUNCT
admet-2774	152	145	rsm	rsm	NOUN
admet-2774	152	146	)	)	PUNCT
admet-2774	152	147	analysis	analysis	NOUN
admet-2774	152	148	of	of	ADP
admet-2774	152	149	the	the	DET
admet-2774	152	150	box	box	NOUN
admet-2774	152	151	-	-	PUNCT
admet-2774	152	152	behnken	behnken	VERB
admet-2774	152	153	design	design	NOUN
admet-2774	152	154	:	:	PUNCT
admet-2774	152	155	(	(	PUNCT
admet-2774	152	156	a	a	X
admet-2774	152	157	,	,	PUNCT
admet-2774	152	158	a	a	DET
admet-2774	152	159	'	'	NOUN
admet-2774	152	160	)	)	PUNCT
admet-2774	152	161	2d	2d	NOUN
admet-2774	152	162	contour	contour	NOUN
admet-2774	152	163	and	and	CCONJ
admet-2774	152	164	3d	3d	NUM
admet-2774	152	165	response	response	NOUN
admet-2774	152	166	surface	surface	NOUN
admet-2774	152	167	plots	plot	NOUN
admet-2774	152	168	illustrating	illustrate	VERB
admet-2774	152	169	the	the	DET
admet-2774	152	170	effect	effect	NOUN
admet-2774	152	171	of	of	ADP
admet-2774	152	172	independent	independent	ADJ
admet-2774	152	173	variables	variable	NOUN
admet-2774	152	174	on	on	ADP
admet-2774	152	175	particle	particle	NOUN
admet-2774	152	176	size	size	NOUN
admet-2774	152	177	;	;	PUNCT
admet-2774	152	178	(	(	PUNCT
admet-2774	152	179	b	b	X
admet-2774	152	180	,	,	PUNCT
admet-2774	152	181	b	b	NOUN
admet-2774	152	182	'	'	PUNCT
admet-2774	152	183	)	)	PUNCT
admet-2774	152	184	polydispersity	polydispersity	NOUN
admet-2774	152	185	index	index	NOUN
admet-2774	152	186	(	(	PUNCT
admet-2774	152	187	pdi	pdi	PROPN
admet-2774	152	188	)	)	PUNCT
admet-2774	152	189	;	;	PUNCT
admet-2774	152	190	and	and	CCONJ
admet-2774	152	191	(	(	PUNCT
admet-2774	152	192	c	c	X
admet-2774	152	193	,	,	PUNCT
admet-2774	152	194	c	c	NOUN
admet-2774	152	195	'	'	PUNCT
admet-2774	152	196	)	)	PUNCT
admet-2774	152	197	zeta	zeta	NOUN
admet-2774	152	198	potential	potential	NOUN
admet-2774	152	199	these	these	DET
admet-2774	152	200	graphs	graph	NOUN
admet-2774	152	201	effectively	effectively	ADV
admet-2774	152	202	map	map	VERB
admet-2774	152	203	the	the	DET
admet-2774	152	204	influence	influence	NOUN
admet-2774	152	205	of	of	ADP
admet-2774	152	206	independent	independent	ADJ
admet-2774	152	207	variables	variable	NOUN
admet-2774	152	208	on	on	ADP
admet-2774	152	209	the	the	DET
admet-2774	152	210	characteristics	characteristic	NOUN
admet-2774	152	211	of	of	ADP
admet-2774	152	212	inh	inh	PROPN
admet-2774	152	213	-	-	PUNCT
admet-2774	152	214	loaded	load	VERB
admet-2774	152	215	pcl	pcl	PROPN
admet-2774	152	216	nanoparticles	nanoparticle	NOUN
admet-2774	152	217	,	,	PUNCT
admet-2774	152	218	which	which	PRON
admet-2774	152	219	aids	aid	VERB
admet-2774	152	220	in	in	ADP
admet-2774	152	221	identifying	identify	VERB
admet-2774	152	222	optimal	optimal	ADJ
admet-2774	152	223	experimental	experimental	ADJ
admet-2774	152	224	conditions	condition	NOUN
admet-2774	152	225	while	while	SCONJ
admet-2774	152	226	reinforcing	reinforce	VERB
admet-2774	152	227	the	the	DET
admet-2774	152	228	statistical	statistical	ADJ
admet-2774	152	229	findings	finding	NOUN
admet-2774	152	230	.	.	PUNCT
admet-2774	153	1	admet	admet	PROPN
admet-2774	153	2	&	&	CCONJ
admet-2774	153	3	dmpk	dmpk	PROPN
admet-2774	153	4	13(4	13(4	NUM
admet-2774	153	5	)	)	PUNCT
admet-2774	153	6	(	(	PUNCT
admet-2774	153	7	2025	2025	NUM
admet-2774	153	8	)	)	PUNCT
admet-2774	153	9	2774	2774	NUM
admet-2774	153	10	freeze	freeze	NOUN
admet-2774	153	11	-	-	PUNCT
admet-2774	153	12	dried	dry	VERB
admet-2774	153	13	isoniazid	isoniazid	NOUN
admet-2774	153	14	-	-	PUNCT
admet-2774	153	15	loaded	load	VERB
admet-2774	153	16	poly	poly	ADJ
admet-2774	153	17	-	-	PUNCT
admet-2774	153	18	ε	ε	NOUN
admet-2774	153	19	-	-	PUNCT
admet-2774	153	20	caprolactone	caprolactone	ADJ
admet-2774	153	21	nanoparticles	nanoparticle	NOUN
admet-2774	153	22	doi	doi	NOUN
admet-2774	153	23	:	:	PUNCT
admet-2774	153	24	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	NOUN
admet-2774	153	25	9	9	NUM
admet-2774	153	26	particle	particle	NOUN
admet-2774	153	27	size	size	NOUN
admet-2774	153	28	,	,	PUNCT
admet-2774	153	29	pdi	pdi	NOUN
admet-2774	153	30	and	and	CCONJ
admet-2774	153	31	zeta	zeta	NOUN
admet-2774	153	32	potential	potential	NOUN
admet-2774	153	33	the	the	DET
admet-2774	153	34	optimized	optimize	VERB
admet-2774	153	35	inh	inh	NOUN
admet-2774	153	36	-	-	PUNCT
admet-2774	153	37	loaded	load	VERB
admet-2774	153	38	pcl	pcl	PROPN
admet-2774	153	39	nanoformulation	nanoformulation	NOUN
admet-2774	153	40	exhibited	exhibit	VERB
admet-2774	153	41	favourable	favourable	ADJ
admet-2774	153	42	physicochemical	physicochemical	ADJ
admet-2774	153	43	properties	property	NOUN
admet-2774	153	44	with	with	ADP
admet-2774	153	45	a	a	DET
admet-2774	153	46	mean	mean	ADJ
admet-2774	153	47	hydrodynamic	hydrodynamic	ADJ
admet-2774	153	48	diameter	diameter	NOUN
admet-2774	153	49	of	of	ADP
admet-2774	153	50	248.4±5.37	248.4±5.37	PROPN
admet-2774	153	51	nm	nm	NOUN
admet-2774	153	52	(	(	PUNCT
admet-2774	153	53	figure	figure	NOUN
admet-2774	153	54	2a	2a	NUM
admet-2774	153	55	)	)	PUNCT
admet-2774	153	56	,	,	PUNCT
admet-2774	153	57	indicating	indicate	VERB
admet-2774	153	58	successful	successful	ADJ
admet-2774	153	59	nanoparticle	nanoparticle	NOUN
admet-2774	153	60	formation	formation	NOUN
admet-2774	153	61	.	.	PUNCT
admet-2774	154	1	the	the	DET
admet-2774	154	2	narrow	narrow	ADJ
admet-2774	154	3	polydispersity	polydispersity	NOUN
admet-2774	154	4	index	index	NOUN
admet-2774	154	5	(	(	PUNCT
admet-2774	154	6	0.067±0.011	0.067±0.011	PROPN
admet-2774	154	7	)	)	PUNCT
admet-2774	154	8	confirmed	confirm	VERB
admet-2774	154	9	a	a	DET
admet-2774	154	10	homogeneous	homogeneous	ADJ
admet-2774	154	11	size	size	NOUN
admet-2774	154	12	distribution	distribution	NOUN
admet-2774	154	13	,	,	PUNCT
admet-2774	154	14	while	while	SCONJ
admet-2774	154	15	the	the	DET
admet-2774	154	16	zeta	zeta	PROPN
admet-2774	154	17	potential	potential	NOUN
admet-2774	154	18	of	of	ADP
admet-2774	154	19	-24.8±0.30	-24.8±0.30	NUM
admet-2774	154	20	mv	mv	PROPN
admet-2774	154	21	(	(	PUNCT
admet-2774	154	22	figure	figure	NOUN
admet-2774	154	23	2b	2b	NOUN
admet-2774	154	24	)	)	PUNCT
admet-2774	154	25	suggested	suggest	VERB
admet-2774	154	26	good	good	ADJ
admet-2774	154	27	colloidal	colloidal	NOUN
admet-2774	154	28	stability	stability	NOUN
admet-2774	154	29	.	.	PUNCT
admet-2774	155	1	these	these	DET
admet-2774	155	2	results	result	NOUN
admet-2774	155	3	validate	validate	VERB
admet-2774	155	4	the	the	DET
admet-2774	155	5	effectiveness	effectiveness	NOUN
admet-2774	155	6	of	of	ADP
admet-2774	155	7	the	the	DET
admet-2774	155	8	microreactor	microreactor	NOUN
admet-2774	155	9	-	-	PUNCT
admet-2774	155	10	assisted	assist	VERB
admet-2774	155	11	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	155	12	method	method	NOUN
admet-2774	155	13	for	for	ADP
admet-2774	155	14	producing	produce	VERB
admet-2774	155	15	inh	inh	NOUN
admet-2774	155	16	-	-	PUNCT
admet-2774	155	17	loaded	load	VERB
admet-2774	155	18	pcl	pcl	PROPN
admet-2774	155	19	nanoparticles	nanoparticle	NOUN
admet-2774	155	20	with	with	ADP
admet-2774	155	21	optimal	optimal	ADJ
admet-2774	155	22	characteristics	characteristic	NOUN
admet-2774	155	23	.	.	PUNCT
admet-2774	156	1	a	a	DET
admet-2774	156	2	b	b	NOUN
admet-2774	156	3	particle	particle	NOUN
admet-2774	156	4	size	size	NOUN
admet-2774	156	5	,	,	PUNCT
admet-2774	156	6	nm	nm	DET
admet-2774	156	7	apparent	apparent	ADJ
admet-2774	156	8	zeta	zeta	NOUN
admet-2774	156	9	potential	potential	NOUN
admet-2774	156	10	,	,	PUNCT
admet-2774	156	11	mv	mv	PROPN
admet-2774	156	12	10	10	NUM
admet-2774	156	13	m	m	PROPN
admet-2774	156	14	5	5	NUM
admet-2774	156	15	m	m	PROPN
admet-2774	156	16	figure	figure	NOUN
admet-2774	156	17	2	2	NUM
admet-2774	156	18	.	.	NOUN
admet-2774	156	19	physicochemical	physicochemical	ADJ
admet-2774	156	20	characterization	characterization	NOUN
admet-2774	156	21	of	of	ADP
admet-2774	156	22	inh	inh	NOUN
admet-2774	156	23	-	-	PUNCT
admet-2774	156	24	loaded	load	VERB
admet-2774	156	25	pcl	pcl	PROPN
admet-2774	156	26	nanoparticles	nanoparticle	NOUN
admet-2774	156	27	:	:	PUNCT
admet-2774	156	28	(	(	PUNCT
admet-2774	156	29	a	a	X
admet-2774	156	30	)	)	PUNCT
admet-2774	156	31	hydrodynamic	hydrodynamic	ADJ
admet-2774	156	32	size	size	NOUN
admet-2774	156	33	distribution	distribution	NOUN
admet-2774	156	34	,	,	PUNCT
admet-2774	156	35	(	(	PUNCT
admet-2774	156	36	b	b	X
admet-2774	156	37	)	)	PUNCT
admet-2774	156	38	surface	surface	NOUN
admet-2774	156	39	charge	charge	NOUN
admet-2774	156	40	(	(	PUNCT
admet-2774	156	41	zeta	zeta	NOUN
admet-2774	156	42	potential	potential	NOUN
admet-2774	156	43	)	)	PUNCT
admet-2774	156	44	(	(	PUNCT
admet-2774	156	45	dynamic	dynamic	ADJ
admet-2774	156	46	light	light	NOUN
admet-2774	156	47	scattering	scattering	NOUN
admet-2774	156	48	,	,	PUNCT
admet-2774	156	49	dls	dls	PROPN
admet-2774	156	50	)	)	PUNCT
admet-2774	156	51	,	,	PUNCT
admet-2774	156	52	data	datum	NOUN
admet-2774	156	53	represent	represent	VERB
admet-2774	156	54	mean	mean	NOUN
admet-2774	156	55	±	±	NUM
admet-2774	156	56	sd	sd	NOUN
admet-2774	156	57	(	(	PUNCT
admet-2774	156	58	n	n	NOUN
admet-2774	156	59	=	=	SYM
admet-2774	156	60	3	3	NUM
admet-2774	156	61	)	)	PUNCT
admet-2774	156	62	and	and	CCONJ
admet-2774	156	63	(	(	PUNCT
admet-2774	156	64	c	c	X
admet-2774	156	65	,	,	PUNCT
admet-2774	156	66	d	d	NOUN
admet-2774	156	67	)	)	PUNCT
admet-2774	156	68	scanning	scan	VERB
admet-2774	156	69	electron	electron	NOUN
admet-2774	156	70	microscopy	microscopy	NOUN
admet-2774	156	71	(	(	PUNCT
admet-2774	156	72	sem	sem	NOUN
admet-2774	156	73	)	)	PUNCT
admet-2774	156	74	micrographs	micrograph	NOUN
admet-2774	156	75	(	(	PUNCT
admet-2774	156	76	acceleration	acceleration	NOUN
admet-2774	156	77	voltage	voltage	NOUN
admet-2774	156	78	:	:	PUNCT
admet-2774	156	79	10	10	NUM
admet-2774	156	80	kv	kv	NOUN
admet-2774	156	81	)	)	PUNCT
admet-2774	156	82	entrapment	entrapment	ADJ
admet-2774	156	83	efficiency	efficiency	NOUN
admet-2774	156	84	and	and	CCONJ
admet-2774	156	85	drug	drug	NOUN
admet-2774	156	86	loading	load	VERB
admet-2774	156	87	the	the	DET
admet-2774	156	88	encapsulation	encapsulation	NOUN
admet-2774	156	89	efficiency	efficiency	NOUN
admet-2774	156	90	of	of	ADP
admet-2774	156	91	the	the	DET
admet-2774	156	92	lyophilized	lyophilized	ADJ
admet-2774	156	93	inh	inh	NOUN
admet-2774	156	94	-	-	PUNCT
admet-2774	156	95	loaded	load	VERB
admet-2774	156	96	pcl	pcl	PROPN
admet-2774	156	97	nanoparticles	nanoparticle	NOUN
admet-2774	156	98	was	be	AUX
admet-2774	156	99	evaluated	evaluate	VERB
admet-2774	156	100	by	by	ADP
admet-2774	156	101	analysing	analyse	VERB
admet-2774	156	102	the	the	DET
admet-2774	156	103	supernatant	supernatant	NOUN
admet-2774	156	104	.	.	PUNCT
admet-2774	157	1	this	this	PRON
admet-2774	157	2	involved	involve	VERB
admet-2774	157	3	quantifying	quantify	VERB
admet-2774	157	4	the	the	DET
admet-2774	157	5	unencapsulated	unencapsulated	ADJ
admet-2774	157	6	inh	inh	NOUN
admet-2774	157	7	in	in	ADP
admet-2774	157	8	the	the	DET
admet-2774	157	9	aqueous	aqueous	ADJ
admet-2774	157	10	phase	phase	NOUN
admet-2774	157	11	and	and	CCONJ
admet-2774	157	12	comparing	compare	VERB
admet-2774	157	13	it	it	PRON
admet-2774	157	14	to	to	ADP
admet-2774	157	15	the	the	DET
admet-2774	157	16	initial	initial	ADJ
admet-2774	157	17	theoretical	theoretical	ADJ
admet-2774	157	18	drug	drug	NOUN
admet-2774	157	19	input	input	NOUN
admet-2774	157	20	.	.	PUNCT
admet-2774	158	1	the	the	DET
admet-2774	158	2	inh	inh	NOUN
admet-2774	158	3	-	-	PUNCT
admet-2774	158	4	loaded	load	VERB
admet-2774	158	5	pcl	pcl	PROPN
admet-2774	158	6	nanoparticles	nanoparticle	NOUN
admet-2774	158	7	exhibited	exhibit	VERB
admet-2774	158	8	high	high	ADJ
admet-2774	158	9	drug	drug	NOUN
admet-2774	158	10	encapsulation	encapsulation	NOUN
admet-2774	158	11	efficiency	efficiency	NOUN
admet-2774	158	12	(	(	PUNCT
admet-2774	158	13	82.26±4.36	82.26±4.36	NUM
admet-2774	158	14	%	%	NOUN
admet-2774	158	15	)	)	PUNCT
admet-2774	158	16	and	and	CCONJ
admet-2774	158	17	a	a	DET
admet-2774	158	18	loading	loading	NOUN
admet-2774	158	19	capacity	capacity	NOUN
admet-2774	158	20	of	of	ADP
admet-2774	158	21	9.28±0.28	9.28±0.28	NUM
admet-2774	158	22	wt.%	wt.%	ADJ
admet-2774	158	23	(	(	PUNCT
admet-2774	158	24	mean	mean	PROPN
admet-2774	158	25	±	±	NUM
admet-2774	158	26	sd	sd	NOUN
admet-2774	158	27	,	,	PUNCT
admet-2774	158	28	n	n	NOUN
admet-2774	158	29	=	=	SYM
admet-2774	158	30	3	3	NUM
admet-2774	158	31	)	)	PUNCT
admet-2774	158	32	.	.	PUNCT
admet-2774	159	1	several	several	ADJ
admet-2774	159	2	studies	study	NOUN
admet-2774	159	3	utilizing	utilize	VERB
admet-2774	159	4	pcl	pcl	PROPN
admet-2774	159	5	-	-	PUNCT
admet-2774	159	6	based	base	VERB
admet-2774	159	7	nanoparticle	nanoparticle	NOUN
admet-2774	159	8	systems	system	NOUN
admet-2774	159	9	have	have	AUX
admet-2774	159	10	reported	report	VERB
admet-2774	159	11	drug	drug	NOUN
admet-2774	159	12	loading	loading	NOUN
admet-2774	159	13	capacities	capacity	NOUN
admet-2774	159	14	and	and	CCONJ
admet-2774	159	15	encapsulation	encapsulation	NOUN
admet-2774	159	16	efficiencies	efficiency	NOUN
admet-2774	159	17	comparable	comparable	ADJ
admet-2774	159	18	to	to	ADP
admet-2774	159	19	our	our	PRON
admet-2774	159	20	results	result	NOUN
admet-2774	159	21	.	.	PUNCT
admet-2774	160	1	notably	notably	ADV
admet-2774	160	2	,	,	PUNCT
admet-2774	160	3	zhang	zhang	PROPN
admet-2774	160	4	et	et	PROPN
admet-2774	160	5	al	al	PROPN
admet-2774	160	6	.	.	PUNCT
admet-2774	161	1	[	[	X
admet-2774	161	2	44	44	NUM
admet-2774	161	3	]	]	PUNCT
admet-2774	161	4	research	research	NOUN
admet-2774	161	5	employing	employ	VERB
admet-2774	161	6	pcl	pcl	PROPN
admet-2774	161	7	/	/	SYM
admet-2774	161	8	poloxamer	poloxamer	NOUN
admet-2774	161	9	188	188	NUM
admet-2774	161	10	nanoparticles	nanoparticle	NOUN
admet-2774	161	11	achieved	achieve	VERB
admet-2774	161	12	a	a	DET
admet-2774	161	13	loading	loading	NOUN
admet-2774	161	14	capacity	capacity	NOUN
admet-2774	161	15	of	of	ADP
admet-2774	161	16	10.05	10.05	NUM
admet-2774	161	17	%	%	NOUN
admet-2774	161	18	,	,	PUNCT
admet-2774	161	19	while	while	SCONJ
admet-2774	161	20	plain	plain	ADJ
admet-2774	161	21	pcl	pcl	PROPN
admet-2774	161	22	nanoparticles	nanoparticle	NOUN
admet-2774	161	23	showed	show	VERB
admet-2774	161	24	a	a	DET
admet-2774	161	25	slightly	slightly	ADV
admet-2774	161	26	lower	low	ADJ
admet-2774	161	27	value	value	NOUN
admet-2774	161	28	of	of	ADP
admet-2774	161	29	9.98	9.98	NUM
admet-2774	161	30	%	%	NOUN
admet-2774	161	31	,	,	PUNCT
admet-2774	161	32	with	with	ADP
admet-2774	161	33	both	both	DET
admet-2774	161	34	systems	system	NOUN
admet-2774	161	35	demonstrating	demonstrate	VERB
admet-2774	161	36	encapsulation	encapsulation	NOUN
admet-2774	161	37	efficiencies	efficiency	NOUN
admet-2774	161	38	above	above	ADP
admet-2774	161	39	70	70	NUM
admet-2774	161	40	%	%	NOUN
admet-2774	161	41	.	.	PUNCT
admet-2774	162	1	these	these	DET
admet-2774	162	2	findings	finding	NOUN
admet-2774	162	3	corroborate	corroborate	VERB
admet-2774	162	4	our	our	PRON
admet-2774	162	5	experimental	experimental	ADJ
admet-2774	162	6	outcomes	outcome	NOUN
admet-2774	162	7	and	and	CCONJ
admet-2774	162	8	validate	validate	VERB
admet-2774	162	9	the	the	DET
admet-2774	162	10	effectiveness	effectiveness	NOUN
admet-2774	162	11	of	of	ADP
admet-2774	162	12	pcl	pcl	PROPN
admet-2774	162	13	-	-	PUNCT
admet-2774	162	14	based	base	VERB
admet-2774	162	15	delivery	delivery	NOUN
admet-2774	162	16	systems	system	NOUN
admet-2774	162	17	for	for	ADP
admet-2774	162	18	hydrophobic	hydrophobic	NOUN
admet-2774	162	19	drug	drug	NOUN
admet-2774	162	20	encapsulation	encapsulation	NOUN
admet-2774	162	21	[	[	X
admet-2774	162	22	23,45	23,45	NUM
admet-2774	162	23	]	]	PUNCT
admet-2774	162	24	.	.	PUNCT
admet-2774	163	1	these	these	DET
admet-2774	163	2	metrics	metric	NOUN
admet-2774	163	3	confirm	confirm	VERB
admet-2774	163	4	the	the	DET
admet-2774	163	5	successful	successful	ADJ
admet-2774	163	6	entrapment	entrapment	NOUN
admet-2774	163	7	of	of	ADP
admet-2774	163	8	isoniazid	isoniazid	NOUN
admet-2774	163	9	within	within	ADP
admet-2774	163	10	the	the	DET
admet-2774	163	11	polymeric	polymeric	ADJ
admet-2774	163	12	matrix	matrix	NOUN
admet-2774	163	13	,	,	PUNCT
admet-2774	163	14	highlighting	highlight	VERB
admet-2774	163	15	the	the	DET
admet-2774	163	16	formulation	formulation	NOUN
admet-2774	163	17	's	's	PART
admet-2774	163	18	robust	robust	ADJ
admet-2774	163	19	drug	drug	NOUN
admet-2774	163	20	-	-	PUNCT
admet-2774	163	21	loading	loading	NOUN
admet-2774	163	22	capabilities	capability	NOUN
admet-2774	163	23	.	.	PUNCT
admet-2774	164	1	particle	particle	NOUN
admet-2774	164	2	morphology	morphology	NOUN
admet-2774	164	3	the	the	DET
admet-2774	164	4	sem	sem	NOUN
admet-2774	164	5	images	image	NOUN
admet-2774	164	6	of	of	ADP
admet-2774	164	7	lyophilized	lyophilized	ADJ
admet-2774	164	8	inh	inh	NOUN
admet-2774	164	9	-	-	PUNCT
admet-2774	164	10	loaded	load	VERB
admet-2774	164	11	pcl	pcl	PROPN
admet-2774	164	12	nanoparticle	nanoparticle	NOUN
admet-2774	164	13	formulation	formulation	NOUN
admet-2774	164	14	revealed	reveal	VERB
admet-2774	164	15	a	a	DET
admet-2774	164	16	rod	rod	NOUN
admet-2774	164	17	-	-	PUNCT
admet-2774	164	18	like	like	ADJ
admet-2774	164	19	crystal	crystal	NOUN
admet-2774	164	20	structure	structure	NOUN
admet-2774	164	21	with	with	ADP
admet-2774	164	22	a	a	DET
admet-2774	164	23	smooth	smooth	ADJ
admet-2774	164	24	surface	surface	NOUN
admet-2774	164	25	and	and	CCONJ
admet-2774	164	26	smaller	small	ADJ
admet-2774	164	27	particles	particle	NOUN
admet-2774	164	28	adhered	adhere	VERB
admet-2774	164	29	,	,	PUNCT
admet-2774	164	30	indicating	indicate	VERB
admet-2774	164	31	agglomeration	agglomeration	NOUN
admet-2774	164	32	.	.	PUNCT
admet-2774	165	1	figure	figure	NOUN
admet-2774	165	2	2c-2d	2c-2d	NOUN
admet-2774	165	3	freeze	freeze	NOUN
admet-2774	165	4	-	-	PUNCT
admet-2774	165	5	drying	drying	NOUN
admet-2774	165	6	led	lead	VERB
admet-2774	165	7	to	to	ADP
admet-2774	165	8	particle	particle	NOUN
admet-2774	165	9	clustering	clustering	NOUN
admet-2774	165	10	and	and	CCONJ
admet-2774	165	11	possible	possible	ADJ
admet-2774	165	12	crystallization	crystallization	NOUN
admet-2774	165	13	,	,	PUNCT
admet-2774	165	14	affecting	affect	VERB
admet-2774	165	15	overall	overall	ADJ
admet-2774	165	16	nanoparticle	nanoparticle	NOUN
admet-2774	165	17	morphology	morphology	NOUN
admet-2774	166	1	[	[	X
admet-2774	166	2	27	27	NUM
admet-2774	166	3	]	]	PUNCT
admet-2774	166	4	.	.	PUNCT
admet-2774	167	1	in	in	ADP
admet-2774	167	2	te	te	PROPN
admet-2774	167	3	n	n	CCONJ
admet-2774	167	4	si	si	INTJ
admet-2774	168	1	ty	ty	INTJ
admet-2774	168	2	,	,	PUNCT
admet-2774	168	3	%	%	NOUN
admet-2774	168	4	in	in	ADP
admet-2774	168	5	te	te	PROPN
admet-2774	168	6	n	n	CCONJ
admet-2774	168	7	si	si	INTJ
admet-2774	169	1	ty	ty	INTJ
admet-2774	169	2	,	,	PUNCT
admet-2774	169	3	a	a	DET
admet-2774	169	4	.u	.u	NOUN
admet-2774	169	5	.	.	PUNCT
admet-2774	170	1	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	170	2	e.	e.	PROPN
admet-2774	170	3	kole	kole	PROPN
admet-2774	170	4	et	et	PROPN
admet-2774	170	5	al	al	PROPN
admet-2774	170	6	.	.	PROPN
admet-2774	170	7	admet	admet	PROPN
admet-2774	170	8	&	&	CCONJ
admet-2774	170	9	dmpk	dmpk	PROPN
admet-2774	170	10	13(4	13(4	NUM
admet-2774	170	11	)	)	PUNCT
admet-2774	170	12	(	(	PUNCT
admet-2774	170	13	2025	2025	NUM
admet-2774	170	14	)	)	PUNCT
admet-2774	170	15	2774	2774	NUM
admet-2774	170	16	10	10	NUM
admet-2774	170	17	redispersibility	redispersibility	NOUN
admet-2774	170	18	index	index	NOUN
admet-2774	170	19	the	the	DET
admet-2774	170	20	redispersion	redispersion	NOUN
admet-2774	170	21	behaviour	behaviour	NOUN
admet-2774	170	22	of	of	ADP
admet-2774	170	23	lyophilized	lyophilized	ADJ
admet-2774	170	24	inh	inh	PROPN
admet-2774	170	25	-	-	PUNCT
admet-2774	170	26	loaded	load	VERB
admet-2774	170	27	pcl	pcl	PROPN
admet-2774	170	28	nanoparticles	nanoparticle	NOUN
admet-2774	170	29	was	be	AUX
admet-2774	170	30	thoroughly	thoroughly	ADV
admet-2774	170	31	investigated	investigate	VERB
admet-2774	170	32	to	to	PART
admet-2774	170	33	evaluate	evaluate	VERB
admet-2774	170	34	formulation	formulation	NOUN
admet-2774	170	35	stability	stability	NOUN
admet-2774	170	36	and	and	CCONJ
admet-2774	170	37	reconstitution	reconstitution	NOUN
admet-2774	170	38	potential	potential	NOUN
admet-2774	170	39	.	.	PUNCT
admet-2774	171	1	the	the	DET
admet-2774	171	2	lyophilized	lyophilized	ADJ
admet-2774	171	3	inh	inh	PROPN
admet-2774	171	4	-	-	PUNCT
admet-2774	171	5	pcl	pcl	PROPN
admet-2774	171	6	nanoparticles	nanoparticle	NOUN
admet-2774	171	7	exhibited	exhibit	VERB
admet-2774	171	8	excellent	excellent	ADJ
admet-2774	171	9	redispersibility	redispersibility	NOUN
admet-2774	171	10	,	,	PUNCT
admet-2774	171	11	reforming	reform	VERB
admet-2774	171	12	stable	stable	ADJ
admet-2774	171	13	nanoparticles	nanoparticle	NOUN
admet-2774	171	14	(	(	PUNCT
admet-2774	171	15	264.96±10.87	264.96±10.87	NUM
admet-2774	171	16	nm	nm	NOUN
admet-2774	171	17	)	)	PUNCT
admet-2774	171	18	with	with	ADP
admet-2774	171	19	low	low	ADJ
admet-2774	171	20	polydispersity	polydispersity	NOUN
admet-2774	171	21	(	(	PUNCT
admet-2774	171	22	0.129±0.037	0.129±0.037	NUM
admet-2774	171	23	)	)	PUNCT
admet-2774	171	24	and	and	CCONJ
admet-2774	171	25	good	good	ADJ
admet-2774	171	26	colloidal	colloidal	NOUN
admet-2774	171	27	stability	stability	NOUN
admet-2774	171	28	(	(	PUNCT
admet-2774	171	29	-19.7	-19.7	SYM
admet-2774	171	30	±	±	NUM
admet-2774	171	31	0.60	0.60	NUM
admet-2774	171	32	mv	mv	NOUN
admet-2774	171	33	)	)	PUNCT
admet-2774	171	34	upon	upon	SCONJ
admet-2774	171	35	reconstitution	reconstitution	NOUN
admet-2774	171	36	.	.	PUNCT
admet-2774	172	1	the	the	PRON
admet-2774	172	2	rdi	rdi	PROPN
admet-2774	172	3	(	(	PUNCT
admet-2774	172	4	1.066	1.066	PROPN
admet-2774	172	5	)	)	PUNCT
admet-2774	172	6	confirmed	confirm	VERB
admet-2774	172	7	ideal	ideal	ADJ
admet-2774	172	8	reconstitution	reconstitution	NOUN
admet-2774	172	9	with	with	ADP
admet-2774	172	10	minimal	minimal	ADJ
admet-2774	172	11	aggregation	aggregation	NOUN
admet-2774	172	12	.	.	PUNCT
admet-2774	173	1	these	these	DET
admet-2774	173	2	results	result	NOUN
admet-2774	173	3	demonstrate	demonstrate	VERB
admet-2774	173	4	the	the	DET
admet-2774	173	5	successful	successful	ADJ
admet-2774	173	6	preservation	preservation	NOUN
admet-2774	173	7	of	of	ADP
admet-2774	173	8	nanoscale	nanoscale	NOUN
admet-2774	173	9	properties	property	NOUN
admet-2774	173	10	during	during	ADP
admet-2774	173	11	lyophilization	lyophilization	NOUN
admet-2774	173	12	.	.	PUNCT
admet-2774	174	1	the	the	DET
admet-2774	174	2	formulation	formulation	NOUN
admet-2774	174	3	maintains	maintain	VERB
admet-2774	174	4	pharmaceutical	pharmaceutical	ADJ
admet-2774	174	5	suitability	suitability	NOUN
admet-2774	174	6	post	post	ADJ
admet-2774	174	7	-	-	ADJ
admet-2774	174	8	freeze	freeze	ADJ
admet-2774	174	9	-	-	PUNCT
admet-2774	174	10	drying	dry	VERB
admet-2774	174	11	and	and	CCONJ
admet-2774	174	12	storage	storage	NOUN
admet-2774	174	13	.	.	PUNCT
admet-2774	175	1	fourier	fourier	PROPN
admet-2774	175	2	transform	transform	VERB
admet-2774	175	3	infrared	infrared	ADJ
admet-2774	175	4	spectroscopy	spectroscopy	VERB
admet-2774	175	5	the	the	DET
admet-2774	175	6	ftir	ftir	PROPN
admet-2774	175	7	spectrum	spectrum	NOUN
admet-2774	175	8	of	of	ADP
admet-2774	175	9	inh	inh	PROPN
admet-2774	175	10	exhibited	exhibit	VERB
admet-2774	175	11	characteristic	characteristic	ADJ
admet-2774	175	12	functional	functional	ADJ
admet-2774	175	13	group	group	NOUN
admet-2774	175	14	peaks	peak	NOUN
admet-2774	175	15	,	,	PUNCT
admet-2774	175	16	including	include	VERB
admet-2774	175	17	o	o	NOUN
admet-2774	175	18	-	-	NOUN
admet-2774	175	19	h	h	NOUN
admet-2774	175	20	stretching	stretch	VERB
admet-2774	175	21	at	at	ADP
admet-2774	175	22	3239.82	3239.82	NUM
admet-2774	175	23	cm-¹	cm-¹	NOUN
admet-2774	175	24	,	,	PUNCT
admet-2774	175	25	n	n	CCONJ
admet-2774	175	26	-	-	PUNCT
admet-2774	175	27	h	h	NOUN
admet-2774	175	28	stretching	stretching	NOUN
admet-2774	175	29	at	at	ADP
admet-2774	175	30	3461.69	3461.69	NUM
admet-2774	175	31	cm-¹	cm-¹	NOUN
admet-2774	175	32	,	,	PUNCT
admet-2774	176	1	c≡n	c≡n	NOUN
admet-2774	176	2	stretching	stretch	VERB
admet-2774	176	3	at	at	ADP
admet-2774	176	4	2212.17	2212.17	NUM
admet-2774	176	5	cm-¹	cm-¹	NOUN
admet-2774	176	6	,	,	PUNCT
admet-2774	176	7	c	c	PROPN
admet-2774	176	8	=	=	X
admet-2774	176	9	o	o	X
admet-2774	176	10	stretching	stretch	VERB
admet-2774	176	11	at	at	ADP
admet-2774	176	12	1716.35	1716.35	NUM
admet-2774	176	13	cm-¹	cm-¹	NOUN
admet-2774	176	14	,	,	PUNCT
admet-2774	176	15	ch₃	ch₃	NOUN
admet-2774	176	16	stretching	stretch	VERB
admet-2774	176	17	at	at	ADP
admet-2774	176	18	1133.34	1133.34	NUM
admet-2774	176	19	cm-¹	cm-¹	NOUN
admet-2774	176	20	,	,	PUNCT
admet-2774	176	21	n	n	CCONJ
admet-2774	176	22	-	-	PUNCT
admet-2774	176	23	h	h	NOUN
admet-2774	176	24	bending	bending	NOUN
admet-2774	176	25	at	at	ADP
admet-2774	176	26	1629.98	1629.98	NUM
admet-2774	176	27	cm-¹	cm-¹	NOUN
admet-2774	176	28	,	,	PUNCT
admet-2774	176	29	pyridine	pyridine	NOUN
admet-2774	176	30	ring	ring	NOUN
admet-2774	176	31	vibrations	vibration	NOUN
admet-2774	176	32	at	at	ADP
admet-2774	176	33	1403.65	1403.65	NUM
admet-2774	176	34	cm-¹	cm-¹	NOUN
admet-2774	176	35	and	and	CCONJ
admet-2774	176	36	free	free	ADJ
admet-2774	176	37	nh₂	nh₂	NOUN
admet-2774	176	38	at	at	ADP
admet-2774	176	39	1215.17	1215.17	NUM
admet-2774	176	40	cm-¹	cm-¹	NOUN
admet-2774	176	41	,	,	PUNCT
admet-2774	176	42	confirming	confirm	VERB
admet-2774	176	43	its	its	PRON
admet-2774	176	44	structural	structural	ADJ
admet-2774	176	45	integrity	integrity	NOUN
admet-2774	176	46	[	[	X
admet-2774	176	47	46	46	NUM
admet-2774	176	48	]	]	PUNCT
admet-2774	176	49	.	.	PUNCT
admet-2774	177	1	similarly	similarly	ADV
admet-2774	177	2	,	,	PUNCT
admet-2774	177	3	pcl	pcl	PROPN
admet-2774	177	4	displayed	display	VERB
admet-2774	177	5	distinct	distinct	ADJ
admet-2774	177	6	absorptions	absorption	NOUN
admet-2774	177	7	for	for	ADP
admet-2774	177	8	asymmetric	asymmetric	ADJ
admet-2774	177	9	ch₂	ch₂	NOUN
admet-2774	177	10	stretching	stretching	NOUN
admet-2774	177	11	(	(	PUNCT
admet-2774	177	12	2979.00	2979.00	NUM
admet-2774	177	13	cm-¹	cm-¹	NOUN
admet-2774	177	14	)	)	PUNCT
admet-2774	177	15	,	,	PUNCT
admet-2774	177	16	symmetric	symmetric	ADJ
admet-2774	177	17	ch₂	ch₂	NOUN
admet-2774	177	18	stretching	stretch	VERB
admet-2774	177	19	(	(	PUNCT
admet-2774	177	20	2893.19	2893.19	NUM
admet-2774	177	21	cm-¹	cm-¹	NOUN
admet-2774	177	22	)	)	PUNCT
admet-2774	177	23	,	,	PUNCT
admet-2774	178	1	c	c	X
admet-2774	178	2	=	=	NOUN
admet-2774	178	3	o	o	X
admet-2774	178	4	stretching	stretch	VERB
admet-2774	178	5	(	(	PUNCT
admet-2774	178	6	1813.80	1813.80	NUM
admet-2774	178	7	cm-¹	cm-¹	NOUN
admet-2774	178	8	)	)	PUNCT
admet-2774	178	9	,	,	PUNCT
admet-2774	178	10	and	and	CCONJ
admet-2774	178	11	asymmetric	asymmetric	ADJ
admet-2774	178	12	coc	coc	NOUN
admet-2774	178	13	stretching	stretch	VERB
admet-2774	178	14	(	(	PUNCT
admet-2774	178	15	1717.89	1717.89	NUM
admet-2774	178	16	,	,	PUNCT
admet-2774	178	17	1667.28	1667.28	NUM
admet-2774	178	18	and	and	CCONJ
admet-2774	178	19	1149.65	1149.65	NUM
admet-2774	178	20	cm-¹	cm-¹	NOUN
admet-2774	178	21	)	)	PUNCT
admet-2774	178	22	,	,	PUNCT
admet-2774	178	23	validating	validate	VERB
admet-2774	178	24	its	its	PRON
admet-2774	178	25	polymer	polymer	NOUN
admet-2774	178	26	structure	structure	NOUN
admet-2774	178	27	[	[	X
admet-2774	178	28	47	47	NUM
admet-2774	178	29	]	]	PUNCT
admet-2774	178	30	.	.	PUNCT
admet-2774	179	1	poloxamer-188	poloxamer-188	NOUN
admet-2774	179	2	showed	show	VERB
admet-2774	179	3	prominent	prominent	ADJ
admet-2774	179	4	peaks	peak	NOUN
admet-2774	179	5	for	for	ADP
admet-2774	179	6	o	o	NOUN
admet-2774	179	7	-	-	NOUN
admet-2774	179	8	h	h	ADJ
admet-2774	179	9	stretching	stretching	NOUN
admet-2774	179	10	(	(	PUNCT
admet-2774	179	11	3404.49	3404.49	NUM
admet-2774	179	12	cm-¹	cm-¹	NOUN
admet-2774	179	13	)	)	PUNCT
admet-2774	179	14	,	,	PUNCT
admet-2774	179	15	aliphatic	aliphatic	ADJ
admet-2774	179	16	c	c	X
admet-2774	179	17	-	-	PUNCT
admet-2774	179	18	h	h	NOUN
admet-2774	179	19	stretching	stretch	VERB
admet-2774	179	20	(	(	PUNCT
admet-2774	179	21	2881.09	2881.09	NUM
admet-2774	179	22	cm-¹	cm-¹	NOUN
admet-2774	179	23	)	)	PUNCT
admet-2774	179	24	,	,	PUNCT
admet-2774	179	25	in	in	ADP
admet-2774	179	26	-	-	PUNCT
admet-2774	179	27	plane	plane	NOUN
admet-2774	179	28	o	o	NOUN
admet-2774	179	29	-	-	NOUN
admet-2774	179	30	h	h	ADJ
admet-2774	179	31	bending	bending	NOUN
admet-2774	179	32	(	(	PUNCT
admet-2774	179	33	1363.27	1363.27	NUM
admet-2774	179	34	cm-¹	cm-¹	NOUN
admet-2774	179	35	)	)	PUNCT
admet-2774	179	36	,	,	PUNCT
admet-2774	179	37	and	and	CCONJ
admet-2774	179	38	c	c	X
admet-2774	179	39	-	-	PUNCT
admet-2774	179	40	o	o	NOUN
admet-2774	179	41	stretching	stretching	NOUN
admet-2774	179	42	(	(	PUNCT
admet-2774	179	43	2117.85	2117.85	NUM
admet-2774	179	44	cm-¹	cm-¹	NOUN
admet-2774	179	45	)	)	PUNCT
admet-2774	179	46	,	,	PUNCT
admet-2774	179	47	consistent	consistent	ADJ
admet-2774	179	48	with	with	ADP
admet-2774	179	49	reported	report	VERB
admet-2774	179	50	data	datum	NOUN
admet-2774	179	51	[	[	X
admet-2774	179	52	48	48	NUM
admet-2774	179	53	]	]	PUNCT
admet-2774	179	54	.	.	PUNCT
admet-2774	180	1	in	in	ADP
admet-2774	180	2	the	the	DET
admet-2774	180	3	inh	inh	NOUN
admet-2774	180	4	-	-	PUNCT
admet-2774	180	5	loaded	load	VERB
admet-2774	180	6	pcl	pcl	PROPN
admet-2774	180	7	nanoparticles	nanoparticle	NOUN
admet-2774	180	8	,	,	PUNCT
admet-2774	180	9	the	the	DET
admet-2774	180	10	spectrum	spectrum	NOUN
admet-2774	180	11	revealed	reveal	VERB
admet-2774	180	12	overlapping	overlap	VERB
admet-2774	180	13	drug	drug	NOUN
admet-2774	180	14	and	and	CCONJ
admet-2774	180	15	polymer	polymer	NOUN
admet-2774	180	16	peaks	peak	NOUN
admet-2774	180	17	with	with	ADP
admet-2774	180	18	minor	minor	ADJ
admet-2774	180	19	shifts	shift	NOUN
admet-2774	180	20	:	:	PUNCT
admet-2774	180	21	o	o	X
admet-2774	180	22	-	-	NOUN
admet-2774	180	23	h	h	ADJ
admet-2774	180	24	stretching	stretch	VERB
admet-2774	180	25	(	(	PUNCT
admet-2774	180	26	3274.65	3274.65	NUM
admet-2774	180	27	cm-¹	cm-¹	NOUN
admet-2774	180	28	)	)	PUNCT
admet-2774	180	29	,	,	PUNCT
admet-2774	180	30	n	n	CCONJ
admet-2774	180	31	-	-	PUNCT
admet-2774	180	32	h	h	NOUN
admet-2774	180	33	stretching	stretch	VERB
admet-2774	180	34	(	(	PUNCT
admet-2774	180	35	3380.81	3380.81	NUM
admet-2774	180	36	cm-¹	cm-¹	NOUN
admet-2774	180	37	)	)	PUNCT
admet-2774	180	38	,	,	PUNCT
admet-2774	180	39	c≡n	c≡n	NOUN
admet-2774	180	40	stretching	stretching	NOUN
admet-2774	180	41	(	(	PUNCT
admet-2774	180	42	2201.84	2201.84	NUM
admet-2774	180	43	cm-¹	cm-¹	NOUN
admet-2774	180	44	)	)	PUNCT
admet-2774	180	45	,	,	PUNCT
admet-2774	180	46	c	c	X
admet-2774	180	47	=	=	NOUN
admet-2774	180	48	o	o	X
admet-2774	180	49	stretching	stretch	VERB
admet-2774	180	50	(	(	PUNCT
admet-2774	180	51	1664.07	1664.07	NUM
admet-2774	180	52	cm-¹	cm-¹	NOUN
admet-2774	180	53	)	)	PUNCT
admet-2774	180	54	,	,	PUNCT
admet-2774	180	55	ch₃	ch₃	PROPN
admet-2774	180	56	stretching	stretching	NOUN
admet-2774	180	57	(	(	PUNCT
admet-2774	180	58	1191.58	1191.58	NUM
admet-2774	180	59	cm-¹	cm-¹	NOUN
admet-2774	180	60	)	)	PUNCT
admet-2774	180	61	,	,	PUNCT
admet-2774	180	62	n	n	CCONJ
admet-2774	180	63	-	-	PUNCT
admet-2774	180	64	h	h	NOUN
admet-2774	180	65	bending	bending	NOUN
admet-2774	180	66	(	(	PUNCT
admet-2774	180	67	1632.59	1632.59	NUM
admet-2774	180	68	cm-¹	cm-¹	NOUN
admet-2774	180	69	)	)	PUNCT
admet-2774	180	70	,	,	PUNCT
admet-2774	180	71	pyridine	pyridine	NOUN
admet-2774	180	72	ring	ring	NOUN
admet-2774	180	73	vibrations	vibration	NOUN
admet-2774	180	74	(	(	PUNCT
admet-2774	180	75	1430.68	1430.68	NUM
admet-2774	180	76	cm-¹	cm-¹	NOUN
admet-2774	180	77	)	)	PUNCT
admet-2774	180	78	,	,	PUNCT
admet-2774	180	79	asymmetric	asymmetric	ADJ
admet-2774	180	80	ch₂	ch₂	NOUN
admet-2774	180	81	stretching	stretch	VERB
admet-2774	180	82	(	(	PUNCT
admet-2774	180	83	2932.89	2932.89	NUM
admet-2774	180	84	cm-¹	cm-¹	NOUN
admet-2774	180	85	)	)	PUNCT
admet-2774	180	86	,	,	PUNCT
admet-2774	180	87	symmetric	symmetric	ADJ
admet-2774	180	88	ch₂	ch₂	NOUN
admet-2774	180	89	stretching	stretch	VERB
admet-2774	180	90	(	(	PUNCT
admet-2774	180	91	2880.72	2880.72	NUM
admet-2774	180	92	cm-¹	cm-¹	NOUN
admet-2774	180	93	)	)	PUNCT
admet-2774	180	94	and	and	CCONJ
admet-2774	180	95	c	c	X
admet-2774	180	96	-	-	PUNCT
admet-2774	180	97	o	o	NOUN
admet-2774	180	98	/	/	SYM
admet-2774	180	99	c	c	NOUN
admet-2774	180	100	-	-	PUNCT
admet-2774	180	101	c	c	NOUN
admet-2774	180	102	stretching	stretch	VERB
admet-2774	180	103	(	(	PUNCT
admet-2774	180	104	1728.43	1728.43	NUM
admet-2774	180	105	and	and	CCONJ
admet-2774	180	106	1664.07	1664.07	NUM
admet-2774	180	107	cm-¹	cm-¹	NOUN
admet-2774	180	108	)	)	PUNCT
admet-2774	180	109	(	(	PUNCT
admet-2774	180	110	figure	figure	NOUN
admet-2774	180	111	3a	3a	NUM
admet-2774	180	112	)	)	PUNCT
admet-2774	180	113	.	.	PUNCT
admet-2774	181	1	the	the	DET
admet-2774	181	2	absence	absence	NOUN
admet-2774	181	3	of	of	ADP
admet-2774	181	4	new	new	ADJ
admet-2774	181	5	peaks	peak	NOUN
admet-2774	181	6	or	or	CCONJ
admet-2774	181	7	significant	significant	ADJ
admet-2774	181	8	band	band	NOUN
admet-2774	181	9	shifts	shift	NOUN
admet-2774	181	10	confirms	confirm	VERB
admet-2774	181	11	that	that	SCONJ
admet-2774	181	12	there	there	PRON
admet-2774	181	13	is	be	VERB
admet-2774	181	14	no	no	DET
admet-2774	181	15	chemical	chemical	NOUN
admet-2774	181	16	interaction	interaction	NOUN
admet-2774	181	17	between	between	ADP
admet-2774	181	18	inh	inh	NOUN
admet-2774	181	19	and	and	CCONJ
admet-2774	181	20	excipients	excipient	NOUN
admet-2774	181	21	during	during	ADP
admet-2774	181	22	nanoparticle	nanoparticle	NOUN
admet-2774	181	23	fabrication	fabrication	NOUN
admet-2774	181	24	.	.	PUNCT
admet-2774	182	1	wavenumber	wavenumber	NOUN
admet-2774	182	2	,	,	PUNCT
admet-2774	182	3	nm	nm	PRON
admet-2774	182	4	temperature	temperature	NOUN
admet-2774	182	5	,	,	PUNCT
admet-2774	182	6	°	°	ADP
admet-2774	182	7	c	c	PROPN
admet-2774	182	8	2	2	NUM
admet-2774	182	9	/	/	SYM
admet-2774	182	10	°	°	NUM
admet-2774	182	11	figure	figure	NOUN
admet-2774	182	12	3	3	NUM
admet-2774	182	13	.	.	PUNCT
admet-2774	182	14	solid	solid	ADJ
admet-2774	182	15	-	-	PUNCT
admet-2774	182	16	state	state	NOUN
admet-2774	182	17	analysis	analysis	NOUN
admet-2774	182	18	of	of	ADP
admet-2774	182	19	inh	inh	NOUN
admet-2774	182	20	-	-	PUNCT
admet-2774	182	21	loaded	load	VERB
admet-2774	182	22	pcl	pcl	PROPN
admet-2774	182	23	nanoparticles	nanoparticle	NOUN
admet-2774	182	24	:	:	PUNCT
admet-2774	182	25	(	(	PUNCT
admet-2774	182	26	a	a	X
admet-2774	182	27	)	)	PUNCT
admet-2774	182	28	fourier	fourier	NOUN
admet-2774	182	29	-	-	PUNCT
admet-2774	182	30	transform	transform	NOUN
admet-2774	182	31	infrared	infrared	NOUN
admet-2774	182	32	(	(	PUNCT
admet-2774	182	33	ftir	ftir	PROPN
admet-2774	182	34	)	)	PUNCT
admet-2774	182	35	spectra	spectra	NOUN
admet-2774	182	36	,	,	PUNCT
admet-2774	182	37	(	(	PUNCT
admet-2774	182	38	b	b	NOUN
admet-2774	182	39	)	)	PUNCT
admet-2774	182	40	differential	differential	NOUN
admet-2774	182	41	scanning	scan	VERB
admet-2774	182	42	calorimetry	calorimetry	NOUN
admet-2774	182	43	(	(	PUNCT
admet-2774	182	44	dsc	dsc	NOUN
admet-2774	182	45	)	)	PUNCT
admet-2774	182	46	thermograms	thermogram	NOUN
admet-2774	182	47	,	,	PUNCT
admet-2774	182	48	and	and	CCONJ
admet-2774	182	49	(	(	PUNCT
admet-2774	182	50	c	c	NOUN
admet-2774	182	51	)	)	PUNCT
admet-2774	182	52	x	x	NOUN
admet-2774	182	53	-	-	NOUN
admet-2774	182	54	ray	ray	NOUN
admet-2774	182	55	diffraction	diffraction	NOUN
admet-2774	182	56	(	(	PUNCT
admet-2774	182	57	xrd	xrd	NOUN
admet-2774	182	58	)	)	PUNCT
admet-2774	182	59	patterns	pattern	NOUN
admet-2774	182	60	differential	differential	ADJ
admet-2774	182	61	scanning	scan	VERB
admet-2774	182	62	calorimetry	calorimetry	NOUN
admet-2774	182	63	figure	figure	NOUN
admet-2774	182	64	3b	3b	NOUN
admet-2774	182	65	provides	provide	VERB
admet-2774	182	66	valuable	valuable	ADJ
admet-2774	182	67	information	information	NOUN
admet-2774	182	68	on	on	ADP
admet-2774	182	69	the	the	DET
admet-2774	182	70	thermal	thermal	ADJ
admet-2774	182	71	behaviour	behaviour	NOUN
admet-2774	182	72	and	and	CCONJ
admet-2774	182	73	changes	change	NOUN
admet-2774	182	74	in	in	ADP
admet-2774	182	75	the	the	DET
admet-2774	182	76	crystallinity	crystallinity	NOUN
admet-2774	182	77	of	of	ADP
admet-2774	182	78	inhloaded	inhloade	VERB
admet-2774	182	79	pcl	pcl	PROPN
admet-2774	182	80	nanoparticles	nanoparticle	NOUN
admet-2774	182	81	compared	compare	VERB
admet-2774	182	82	to	to	ADP
admet-2774	182	83	pure	pure	ADJ
admet-2774	182	84	inh	inh	NOUN
admet-2774	182	85	and	and	CCONJ
admet-2774	182	86	individual	individual	ADJ
admet-2774	182	87	excipients	excipient	NOUN
admet-2774	182	88	.	.	PUNCT
admet-2774	183	1	pure	pure	ADJ
admet-2774	183	2	inh	inh	PROPN
admet-2774	183	3	exhibited	exhibit	VERB
admet-2774	183	4	a	a	DET
admet-2774	183	5	distinct	distinct	ADJ
admet-2774	183	6	endothermic	endothermic	NOUN
admet-2774	183	7	peak	peak	NOUN
admet-2774	183	8	at	at	ADP
admet-2774	183	9	181.36	181.36	NUM
admet-2774	183	10	°	°	NOUN
admet-2774	183	11	c	c	NOUN
admet-2774	183	12	,	,	PUNCT
admet-2774	183	13	corresponding	correspond	VERB
admet-2774	183	14	to	to	ADP
admet-2774	183	15	its	its	PRON
admet-2774	183	16	melting	melting	NOUN
admet-2774	183	17	point	point	NOUN
admet-2774	183	18	and	and	CCONJ
admet-2774	183	19	indicating	indicate	VERB
admet-2774	183	20	its	its	PRON
admet-2774	183	21	crystalline	crystalline	NOUN
admet-2774	183	22	structure	structure	NOUN
admet-2774	183	23	.	.	PUNCT
admet-2774	184	1	similarly	similarly	ADV
admet-2774	184	2	,	,	PUNCT
admet-2774	184	3	mannitol	mannitol	NOUN
admet-2774	184	4	exhibited	exhibit	VERB
admet-2774	184	5	a	a	DET
admet-2774	184	6	sharp	sharp	ADJ
admet-2774	184	7	peak	peak	NOUN
admet-2774	184	8	at	at	ADP
admet-2774	184	9	178.40	178.40	NUM
admet-2774	184	10	°	°	NOUN
admet-2774	184	11	c	c	NOUN
admet-2774	184	12	,	,	PUNCT
admet-2774	184	13	consistent	consistent	ADJ
admet-2774	184	14	with	with	ADP
admet-2774	184	15	its	its	PRON
admet-2774	184	16	known	know	VERB
admet-2774	184	17	crystalline	crystalline	NOUN
admet-2774	184	18	nature	nature	NOUN
admet-2774	184	19	.	.	PUNCT
admet-2774	185	1	poloxamer188	poloxamer188	NOUN
admet-2774	185	2	,	,	PUNCT
admet-2774	185	3	functioning	function	VERB
admet-2774	185	4	as	as	ADP
admet-2774	185	5	a	a	DET
admet-2774	185	6	surfactant	surfactant	NOUN
admet-2774	185	7	,	,	PUNCT
admet-2774	185	8	showed	show	VERB
admet-2774	185	9	a	a	DET
admet-2774	185	10	mild	mild	ADJ
admet-2774	185	11	endothermic	endothermic	NOUN
admet-2774	185	12	transition	transition	NOUN
admet-2774	185	13	around	around	ADP
admet-2774	185	14	61.44	61.44	NUM
admet-2774	185	15	 	 	SPACE
admet-2774	185	16	°	°	NOUN
admet-2774	185	17	c	c	NOUN
admet-2774	185	18	,	,	PUNCT
admet-2774	185	19	reflecting	reflect	VERB
admet-2774	185	20	its	its	PRON
admet-2774	185	21	semicrystalline	semicrystalline	ADJ
admet-2774	185	22	or	or	CCONJ
admet-2774	185	23	low	low	ADJ
admet-2774	185	24	-	-	PUNCT
admet-2774	185	25	crystallinity	crystallinity	NOUN
admet-2774	185	26	characteristics	characteristic	NOUN
admet-2774	185	27	.	.	PUNCT
admet-2774	186	1	pcl	pcl	PROPN
admet-2774	186	2	exhibited	exhibit	VERB
admet-2774	186	3	a	a	DET
admet-2774	186	4	melting	melting	NOUN
admet-2774	186	5	peak	peak	NOUN
admet-2774	186	6	at	at	ADP
admet-2774	186	7	75.79	75.79	NUM
admet-2774	186	8	°	°	NOUN
admet-2774	186	9	c	c	NOUN
admet-2774	186	10	,	,	PUNCT
admet-2774	186	11	typical	typical	ADJ
admet-2774	186	12	of	of	ADP
admet-2774	186	13	semi	semi	ADJ
admet-2774	186	14	-	-	ADJ
admet-2774	186	15	crystalline	crystalline	ADJ
admet-2774	186	16	polymers	polymer	NOUN
admet-2774	186	17	.	.	PUNCT
admet-2774	187	1	in	in	ADP
admet-2774	187	2	contrast	contrast	NOUN
admet-2774	187	3	,	,	PUNCT
admet-2774	187	4	the	the	DET
admet-2774	187	5	dsc	dsc	NOUN
admet-2774	187	6	thermogram	thermogram	NOUN
admet-2774	187	7	of	of	ADP
admet-2774	187	8	the	the	DET
admet-2774	187	9	inh	inh	NOUN
admet-2774	187	10	-	-	PUNCT
admet-2774	187	11	loaded	load	VERB
admet-2774	187	12	pcl	pcl	PROPN
admet-2774	187	13	nanoparticles	nanoparticle	NOUN
admet-2774	187	14	revealed	reveal	VERB
admet-2774	187	15	notable	notable	ADJ
admet-2774	187	16	differences	difference	NOUN
admet-2774	187	17	.	.	PUNCT
admet-2774	188	1	tr	tr	VERB
admet-2774	188	2	an	an	DET
admet-2774	188	3	sm	sm	NOUN
admet-2774	188	4	it	it	PRON
admet-2774	188	5	ta	ta	ADP
admet-2774	188	6	n	n	PROPN
admet-2774	188	7	ce	ce	PROPN
admet-2774	188	8	,	,	PUNCT
admet-2774	189	1	%	%	INTJ
admet-2774	189	2	h	h	NOUN
admet-2774	190	1	ea	ea	NOUN
admet-2774	190	2	t	t	PROPN
admet-2774	190	3	fl	fl	NUM
admet-2774	191	1	o	o	PROPN
admet-2774	191	2	w	w	NOUN
admet-2774	191	3	,	,	PUNCT
admet-2774	191	4			NOUN
admet-2774	191	5	w	w	NOUN
admet-2774	191	6	in	in	ADP
admet-2774	191	7	te	te	PROPN
admet-2774	191	8	n	n	CCONJ
admet-2774	191	9	si	si	INTJ
admet-2774	191	10	ty	ty	INTJ
admet-2774	191	11	,	,	PUNCT
admet-2774	191	12	a	a	DET
admet-2774	191	13	.u	.u	NOUN
admet-2774	191	14	.	.	PUNCT
admet-2774	192	1	admet	admet	PROPN
admet-2774	192	2	&	&	CCONJ
admet-2774	192	3	dmpk	dmpk	PROPN
admet-2774	192	4	13(4	13(4	NUM
admet-2774	192	5	)	)	PUNCT
admet-2774	192	6	(	(	PUNCT
admet-2774	192	7	2025	2025	NUM
admet-2774	192	8	)	)	PUNCT
admet-2774	192	9	2774	2774	NUM
admet-2774	192	10	freeze	freeze	NOUN
admet-2774	192	11	-	-	PUNCT
admet-2774	192	12	dried	dry	VERB
admet-2774	192	13	isoniazid	isoniazid	NOUN
admet-2774	192	14	-	-	PUNCT
admet-2774	192	15	loaded	load	VERB
admet-2774	192	16	poly	poly	ADJ
admet-2774	192	17	-	-	PUNCT
admet-2774	192	18	ε	ε	NOUN
admet-2774	192	19	-	-	PUNCT
admet-2774	192	20	caprolactone	caprolactone	ADJ
admet-2774	192	21	nanoparticles	nanoparticle	NOUN
admet-2774	192	22	doi	doi	NOUN
admet-2774	192	23	:	:	PUNCT
admet-2774	192	24	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	192	25	11	11	NUM
admet-2774	192	26	the	the	DET
admet-2774	192	27	absence	absence	NOUN
admet-2774	192	28	of	of	ADP
admet-2774	192	29	the	the	DET
admet-2774	192	30	characteristic	characteristic	PROPN
admet-2774	192	31	pcl	pcl	PROPN
admet-2774	192	32	melting	melting	NOUN
admet-2774	192	33	peak	peak	NOUN
admet-2774	192	34	indicates	indicate	VERB
admet-2774	192	35	a	a	DET
admet-2774	192	36	disruption	disruption	NOUN
admet-2774	192	37	in	in	ADP
admet-2774	192	38	the	the	DET
admet-2774	192	39	polymer	polymer	NOUN
admet-2774	192	40	's	's	PART
admet-2774	192	41	crystallinity	crystallinity	NOUN
admet-2774	192	42	,	,	PUNCT
admet-2774	192	43	likely	likely	ADJ
admet-2774	192	44	due	due	ADP
admet-2774	192	45	to	to	ADP
admet-2774	192	46	molecular	molecular	ADJ
admet-2774	192	47	-	-	PUNCT
admet-2774	192	48	level	level	NOUN
admet-2774	192	49	interactions	interaction	NOUN
admet-2774	192	50	between	between	ADP
admet-2774	192	51	inh	inh	PROPN
admet-2774	192	52	and	and	CCONJ
admet-2774	192	53	the	the	DET
admet-2774	192	54	pcl	pcl	PROPN
admet-2774	192	55	matrix	matrix	NOUN
admet-2774	192	56	during	during	ADP
admet-2774	192	57	nanoparticle	nanoparticle	NOUN
admet-2774	192	58	synthesis	synthesis	NOUN
admet-2774	192	59	.	.	PUNCT
admet-2774	193	1	this	this	DET
admet-2774	193	2	absence	absence	NOUN
admet-2774	193	3	suggests	suggest	VERB
admet-2774	193	4	that	that	SCONJ
admet-2774	193	5	inh	inh	PROPN
admet-2774	193	6	was	be	AUX
admet-2774	193	7	successfully	successfully	ADV
admet-2774	193	8	incorporated	incorporate	VERB
admet-2774	193	9	into	into	ADP
admet-2774	193	10	the	the	DET
admet-2774	193	11	polymer	polymer	NOUN
admet-2774	193	12	network	network	NOUN
admet-2774	193	13	,	,	PUNCT
admet-2774	193	14	forming	form	VERB
admet-2774	193	15	an	an	DET
admet-2774	193	16	amorphous	amorphous	ADJ
admet-2774	193	17	drugpolymer	drugpolymer	ADJ
admet-2774	193	18	composite	composite	NOUN
admet-2774	193	19	.	.	PUNCT
admet-2774	194	1	moreover	moreover	ADV
admet-2774	194	2	,	,	PUNCT
admet-2774	194	3	the	the	DET
admet-2774	194	4	melting	melting	NOUN
admet-2774	194	5	point	point	NOUN
admet-2774	194	6	of	of	ADP
admet-2774	194	7	inh	inh	PROPN
admet-2774	194	8	shifted	shift	VERB
admet-2774	194	9	downward	downward	ADV
admet-2774	194	10	to	to	ADP
admet-2774	194	11	162.24	162.24	NUM
admet-2774	194	12	 	 	SPACE
admet-2774	194	13	°	°	ADP
admet-2774	194	14	c	c	NOUN
admet-2774	194	15	within	within	ADP
admet-2774	194	16	the	the	DET
admet-2774	194	17	nanoparticles	nanoparticle	NOUN
admet-2774	194	18	,	,	PUNCT
admet-2774	194	19	suggesting	suggest	VERB
admet-2774	194	20	a	a	DET
admet-2774	194	21	significant	significant	ADJ
admet-2774	194	22	reduction	reduction	NOUN
admet-2774	194	23	in	in	ADP
admet-2774	194	24	its	its	PRON
admet-2774	194	25	crystallinity	crystallinity	NOUN
admet-2774	194	26	.	.	PUNCT
admet-2774	195	1	previously	previously	ADV
admet-2774	195	2	reported	report	VERB
admet-2774	195	3	by	by	ADP
admet-2774	195	4	khuroo	khuroo	PROPN
admet-2774	195	5	et	et	PROPN
admet-2774	195	6	al	al	PROPN
admet-2774	195	7	,	,	PUNCT
admet-2774	195	8	[	[	X
admet-2774	195	9	49	49	NUM
admet-2774	195	10	]	]	PUNCT
admet-2774	195	11	the	the	DET
admet-2774	195	12	development	development	NOUN
admet-2774	195	13	of	of	ADP
admet-2774	195	14	rapid	rapid	ADJ
admet-2774	195	15	-	-	PUNCT
admet-2774	195	16	dissolving	dissolve	VERB
admet-2774	195	17	printlets	printlet	NOUN
admet-2774	195	18	showed	show	VERB
admet-2774	195	19	significant	significant	ADJ
admet-2774	195	20	modification	modification	NOUN
admet-2774	195	21	in	in	ADP
admet-2774	195	22	the	the	DET
admet-2774	195	23	crystalline	crystalline	ADJ
admet-2774	195	24	behaviour	behaviour	NOUN
admet-2774	195	25	of	of	ADP
admet-2774	195	26	inh	inh	PROPN
admet-2774	195	27	.	.	PUNCT
admet-2774	196	1	their	their	PRON
admet-2774	196	2	study	study	NOUN
admet-2774	196	3	observed	observe	VERB
admet-2774	196	4	the	the	DET
admet-2774	196	5	thermal	thermal	ADJ
admet-2774	196	6	behaviour	behaviour	NOUN
admet-2774	196	7	of	of	ADP
admet-2774	196	8	inh	inh	PROPN
admet-2774	196	9	in	in	ADP
admet-2774	196	10	the	the	DET
admet-2774	196	11	printlets	printlet	NOUN
admet-2774	196	12	formulation	formulation	NOUN
admet-2774	196	13	,	,	PUNCT
admet-2774	196	14	which	which	PRON
admet-2774	196	15	strongly	strongly	ADV
admet-2774	196	16	supports	support	VERB
admet-2774	196	17	the	the	DET
admet-2774	196	18	formation	formation	NOUN
admet-2774	196	19	of	of	ADP
admet-2774	196	20	an	an	DET
admet-2774	196	21	amorphous	amorphous	ADJ
admet-2774	196	22	drug	drug	NOUN
admet-2774	196	23	-	-	PUNCT
admet-2774	196	24	polymer	polymer	NOUN
admet-2774	196	25	interaction	interaction	NOUN
admet-2774	196	26	or	or	CCONJ
admet-2774	196	27	a	a	DET
admet-2774	196	28	reduction	reduction	NOUN
admet-2774	196	29	in	in	ADP
admet-2774	196	30	crystallinity	crystallinity	NOUN
admet-2774	196	31	.	.	PUNCT
admet-2774	197	1	this	this	PRON
admet-2774	197	2	is	be	AUX
admet-2774	197	3	evidenced	evidence	VERB
admet-2774	197	4	by	by	ADP
admet-2774	197	5	the	the	DET
admet-2774	197	6	shift	shift	NOUN
admet-2774	197	7	in	in	ADP
admet-2774	197	8	the	the	DET
admet-2774	197	9	inh	inh	PROPN
admet-2774	197	10	melting	melting	NOUN
admet-2774	197	11	peak	peak	NOUN
admet-2774	197	12	from	from	ADP
admet-2774	197	13	174.8	174.8	NUM
admet-2774	197	14	 	 	SPACE
admet-2774	197	15	°	°	ADP
admet-2774	197	16	c	c	NOUN
admet-2774	197	17	(	(	PUNCT
admet-2774	197	18	pure	pure	ADJ
admet-2774	197	19	drug	drug	NOUN
admet-2774	197	20	)	)	PUNCT
admet-2774	197	21	to	to	ADP
admet-2774	197	22	168.3	168.3	NUM
admet-2774	197	23	to	to	ADP
admet-2774	197	24	168.9	168.9	NUM
admet-2774	197	25	 	 	SPACE
admet-2774	197	26	°	°	ADP
admet-2774	197	27	c	c	PROPN
admet-2774	197	28	(	(	PUNCT
admet-2774	197	29	printlets	printlet	NOUN
admet-2774	197	30	)	)	PUNCT
admet-2774	197	31	,	,	PUNCT
admet-2774	197	32	indicating	indicate	VERB
admet-2774	197	33	disruption	disruption	NOUN
admet-2774	197	34	of	of	ADP
admet-2774	197	35	the	the	DET
admet-2774	197	36	crystal	crystal	NOUN
admet-2774	197	37	lattice	lattice	NOUN
admet-2774	197	38	due	due	ADP
admet-2774	197	39	to	to	ADP
admet-2774	197	40	polymer	polymer	NOUN
admet-2774	197	41	interactions	interaction	NOUN
admet-2774	197	42	.	.	PUNCT
admet-2774	198	1	this	this	DET
admet-2774	198	2	shift	shift	NOUN
admet-2774	198	3	could	could	AUX
admet-2774	198	4	be	be	AUX
admet-2774	198	5	attributed	attribute	VERB
admet-2774	198	6	to	to	ADP
admet-2774	198	7	possible	possible	ADJ
admet-2774	198	8	drug	drug	NOUN
admet-2774	198	9	-	-	PUNCT
admet-2774	198	10	polymer	polymer	NOUN
admet-2774	198	11	interactions	interaction	NOUN
admet-2774	198	12	or	or	CCONJ
admet-2774	198	13	the	the	DET
admet-2774	198	14	formation	formation	NOUN
admet-2774	198	15	of	of	ADP
admet-2774	198	16	smaller	small	ADJ
admet-2774	198	17	and	and	CCONJ
admet-2774	198	18	less	less	ADV
admet-2774	198	19	stable	stable	ADJ
admet-2774	198	20	crystalline	crystalline	NOUN
admet-2774	198	21	domains	domain	NOUN
admet-2774	198	22	of	of	ADP
admet-2774	198	23	inh	inh	NOUN
admet-2774	199	1	[	[	X
admet-2774	199	2	49	49	NUM
admet-2774	199	3	]	]	PUNCT
admet-2774	199	4	.	.	PUNCT
admet-2774	200	1	additionally	additionally	ADV
admet-2774	200	2	,	,	PUNCT
admet-2774	200	3	a	a	DET
admet-2774	200	4	minor	minor	ADJ
admet-2774	200	5	endothermic	endothermic	NOUN
admet-2774	200	6	peak	peak	NOUN
admet-2774	200	7	at	at	ADP
admet-2774	200	8	142.11	142.11	NUM
admet-2774	200	9	 	 	SPACE
admet-2774	200	10	°	°	NOUN
admet-2774	200	11	c	c	NOUN
admet-2774	200	12	was	be	AUX
admet-2774	200	13	observed	observe	VERB
admet-2774	200	14	,	,	PUNCT
admet-2774	200	15	which	which	PRON
admet-2774	200	16	may	may	AUX
admet-2774	200	17	represent	represent	VERB
admet-2774	200	18	trace	trace	NOUN
admet-2774	200	19	amounts	amount	NOUN
admet-2774	200	20	of	of	ADP
admet-2774	200	21	residual	residual	ADJ
admet-2774	200	22	crystalline	crystalline	NOUN
admet-2774	200	23	drug	drug	NOUN
admet-2774	200	24	or	or	CCONJ
admet-2774	200	25	interactions	interaction	NOUN
admet-2774	200	26	with	with	ADP
admet-2774	200	27	excipients	excipient	NOUN
admet-2774	200	28	.	.	PUNCT
admet-2774	201	1	however	however	ADV
admet-2774	201	2	,	,	PUNCT
admet-2774	201	3	the	the	DET
admet-2774	201	4	low	low	ADJ
admet-2774	201	5	intensity	intensity	NOUN
admet-2774	201	6	of	of	ADP
admet-2774	201	7	this	this	DET
admet-2774	201	8	peak	peak	NOUN
admet-2774	201	9	suggests	suggest	VERB
admet-2774	201	10	a	a	DET
admet-2774	201	11	minimal	minimal	ADJ
admet-2774	201	12	impact	impact	NOUN
admet-2774	201	13	on	on	ADP
admet-2774	201	14	the	the	DET
admet-2774	201	15	overall	overall	ADJ
admet-2774	201	16	system	system	NOUN
admet-2774	201	17	.	.	PUNCT
admet-2774	202	1	collectively	collectively	ADV
admet-2774	202	2	,	,	PUNCT
admet-2774	202	3	the	the	DET
admet-2774	202	4	dsc	dsc	NOUN
admet-2774	202	5	results	result	NOUN
admet-2774	202	6	demonstrate	demonstrate	VERB
admet-2774	202	7	that	that	SCONJ
admet-2774	202	8	inh	inh	PROPN
admet-2774	202	9	was	be	AUX
admet-2774	202	10	efficiently	efficiently	ADV
admet-2774	202	11	encapsulated	encapsulate	VERB
admet-2774	202	12	within	within	ADP
admet-2774	202	13	the	the	DET
admet-2774	202	14	pcl	pcl	PROPN
admet-2774	202	15	matrix	matrix	NOUN
admet-2774	202	16	,	,	PUNCT
admet-2774	202	17	with	with	ADP
admet-2774	202	18	notable	notable	ADJ
admet-2774	202	19	changes	change	NOUN
admet-2774	202	20	in	in	ADP
admet-2774	202	21	crystallinity	crystallinity	NOUN
admet-2774	202	22	supporting	support	VERB
admet-2774	202	23	the	the	DET
admet-2774	202	24	formation	formation	NOUN
admet-2774	202	25	of	of	ADP
admet-2774	202	26	a	a	DET
admet-2774	202	27	wellintegrated	wellintegrated	ADJ
admet-2774	202	28	nanocarrier	nanocarrier	NOUN
admet-2774	202	29	system	system	NOUN
admet-2774	202	30	optimized	optimize	VERB
admet-2774	202	31	for	for	ADP
admet-2774	202	32	drug	drug	NOUN
admet-2774	202	33	delivery	delivery	NOUN
admet-2774	202	34	.	.	PUNCT
admet-2774	203	1	x	x	X
admet-2774	203	2	-	-	PUNCT
admet-2774	203	3	ray	ray	NOUN
admet-2774	203	4	diffraction	diffraction	NOUN
admet-2774	203	5	analysis	analysis	NOUN
admet-2774	203	6	figure	figure	NOUN
admet-2774	203	7	3c	3c	NUM
admet-2774	203	8	shows	show	VERB
admet-2774	203	9	the	the	DET
admet-2774	203	10	xrd	xrd	NOUN
admet-2774	203	11	pattern	pattern	NOUN
admet-2774	203	12	of	of	ADP
admet-2774	203	13	pure	pure	ADJ
admet-2774	203	14	inh	inh	PROPN
admet-2774	203	15	,	,	PUNCT
admet-2774	203	16	pcl	pcl	PROPN
admet-2774	203	17	,	,	PUNCT
admet-2774	203	18	polaxomer-188	polaxomer-188	NOUN
admet-2774	203	19	and	and	CCONJ
admet-2774	203	20	inh	inh	NOUN
admet-2774	203	21	-	-	PUNCT
admet-2774	203	22	loaded	load	VERB
admet-2774	203	23	pcl	pcl	PROPN
admet-2774	203	24	nanoparticles	nanoparticle	NOUN
admet-2774	203	25	across	across	ADP
admet-2774	203	26	the	the	DET
admet-2774	203	27	2	2	NUM
admet-2774	203	28	range	range	NOUN
admet-2774	203	29	of	of	ADP
admet-2774	203	30	5	5	NUM
admet-2774	203	31	to	to	ADP
admet-2774	203	32	60˚.	60˚.	NUM
admet-2774	203	33	the	the	DET
admet-2774	203	34	xrd	xrd	NOUN
admet-2774	203	35	analysis	analysis	NOUN
admet-2774	203	36	revealed	reveal	VERB
admet-2774	203	37	a	a	DET
admet-2774	203	38	distinct	distinct	ADJ
admet-2774	203	39	crystallinity	crystallinity	NOUN
admet-2774	203	40	pattern	pattern	NOUN
admet-2774	203	41	for	for	ADP
admet-2774	203	42	each	each	DET
admet-2774	203	43	excipient	excipient	NOUN
admet-2774	203	44	:	:	PUNCT
admet-2774	203	45	pcl	pcl	PROPN
admet-2774	203	46	showed	show	VERB
admet-2774	203	47	characteristic	characteristic	ADJ
admet-2774	203	48	peaks	peak	NOUN
admet-2774	203	49	at	at	ADP
admet-2774	203	50	22.33	22.33	NUM
admet-2774	203	51	and	and	CCONJ
admet-2774	203	52	24.65	24.65	NUM
admet-2774	203	53	°	°	NOUN
admet-2774	203	54	,	,	PUNCT
admet-2774	203	55	poloxamer	poloxamer	NOUN
admet-2774	203	56	188	188	NUM
admet-2774	203	57	at	at	ADP
admet-2774	203	58	19.51	19.51	NUM
admet-2774	203	59	and	and	CCONJ
admet-2774	203	60	23.68	23.68	NUM
admet-2774	203	61	°	°	NOUN
admet-2774	203	62	,	,	PUNCT
admet-2774	203	63	and	and	CCONJ
admet-2774	203	64	mannitol	mannitol	NOUN
admet-2774	203	65	exhibited	exhibit	VERB
admet-2774	203	66	multiple	multiple	ADJ
admet-2774	203	67	sharp	sharp	ADJ
admet-2774	203	68	peaks	peak	NOUN
admet-2774	203	69	between	between	ADP
admet-2774	203	70	11.04	11.04	NUM
admet-2774	203	71	and	and	CCONJ
admet-2774	203	72	44.52	44.52	NUM
admet-2774	203	73	°	°	NOUN
admet-2774	203	74	,	,	PUNCT
admet-2774	203	75	while	while	SCONJ
admet-2774	203	76	pure	pure	ADJ
admet-2774	203	77	inh	inh	PROPN
admet-2774	203	78	demonstrated	demonstrate	VERB
admet-2774	203	79	intense	intense	ADJ
admet-2774	203	80	crystalline	crystalline	NOUN
admet-2774	203	81	peaks	peak	NOUN
admet-2774	203	82	from	from	ADP
admet-2774	203	83	12.37	12.37	NUM
admet-2774	203	84	to	to	ADP
admet-2774	203	85	46.08	46.08	NUM
admet-2774	203	86	°	°	NOUN
admet-2774	203	87	.	.	PUNCT
admet-2774	204	1	the	the	DET
admet-2774	204	2	inh	inh	NOUN
admet-2774	204	3	-	-	PUNCT
admet-2774	204	4	loaded	load	VERB
admet-2774	204	5	pcl	pcl	PROPN
admet-2774	204	6	nanoparticles	nanoparticle	NOUN
admet-2774	204	7	displayed	display	VERB
admet-2774	204	8	a	a	DET
admet-2774	204	9	modified	modify	VERB
admet-2774	204	10	diffraction	diffraction	NOUN
admet-2774	204	11	pattern	pattern	NOUN
admet-2774	204	12	with	with	ADP
admet-2774	204	13	peaks	peak	NOUN
admet-2774	204	14	at	at	ADP
admet-2774	204	15	9.88	9.88	NUM
admet-2774	204	16	,	,	PUNCT
admet-2774	204	17	17.60	17.60	NUM
admet-2774	204	18	,	,	PUNCT
admet-2774	204	19	20.52	20.52	NUM
admet-2774	204	20	and	and	CCONJ
admet-2774	204	21	21.55	21.55	NUM
admet-2774	204	22	°	°	NOUN
admet-2774	204	23	,	,	PUNCT
admet-2774	204	24	where	where	SCONJ
admet-2774	204	25	the	the	DET
admet-2774	204	26	absence	absence	NOUN
admet-2774	204	27	of	of	ADP
admet-2774	204	28	sharpe	sharpe	NOUN
admet-2774	204	29	peaks	peak	NOUN
admet-2774	204	30	and	and	CCONJ
admet-2774	204	31	reduced	reduce	VERB
admet-2774	204	32	pcl	pcl	PROPN
admet-2774	204	33	crystallinity	crystallinity	NOUN
admet-2774	204	34	indicates	indicate	VERB
admet-2774	204	35	successful	successful	ADJ
admet-2774	204	36	inh	inh	PROPN
admet-2774	204	37	encapsulation	encapsulation	NOUN
admet-2774	204	38	and	and	CCONJ
admet-2774	204	39	partial	partial	ADJ
admet-2774	204	40	amorphization	amorphization	NOUN
admet-2774	204	41	within	within	ADP
admet-2774	204	42	the	the	DET
admet-2774	204	43	polymeric	polymeric	ADJ
admet-2774	204	44	matrix	matrix	NOUN
admet-2774	204	45	.	.	PUNCT
admet-2774	205	1	these	these	DET
admet-2774	205	2	structural	structural	ADJ
admet-2774	205	3	changes	change	NOUN
admet-2774	205	4	,	,	PUNCT
admet-2774	205	5	evidenced	evidence	VERB
admet-2774	205	6	by	by	ADP
admet-2774	205	7	peak	peak	NOUN
admet-2774	205	8	broadening	broadening	NOUN
admet-2774	205	9	and	and	CCONJ
admet-2774	205	10	shift	shift	NOUN
admet-2774	205	11	,	,	PUNCT
admet-2774	205	12	correlate	correlate	VERB
admet-2774	205	13	with	with	ADP
admet-2774	205	14	the	the	DET
admet-2774	205	15	formulation	formulation	NOUN
admet-2774	205	16	's	's	PART
admet-2774	205	17	sustained	sustained	ADJ
admet-2774	205	18	release	release	NOUN
admet-2774	205	19	behaviour	behaviour	NOUN
admet-2774	205	20	of	of	ADP
admet-2774	205	21	inh	inh	NOUN
admet-2774	205	22	while	while	SCONJ
admet-2774	205	23	maintaining	maintain	VERB
admet-2774	205	24	sufficient	sufficient	ADJ
admet-2774	205	25	nanoparticle	nanoparticle	NOUN
admet-2774	205	26	stability	stability	NOUN
admet-2774	205	27	through	through	ADP
admet-2774	205	28	preserved	preserve	VERB
admet-2774	205	29	pcl	pcl	PROPN
admet-2774	205	30	crystallinity	crystallinity	NOUN
admet-2774	205	31	.	.	PUNCT
admet-2774	206	1	the	the	DET
admet-2774	206	2	xrd	xrd	PROPN
admet-2774	206	3	data	data	PROPN
admet-2774	206	4	collectively	collectively	ADV
admet-2774	206	5	confirm	confirm	VERB
admet-2774	206	6	the	the	DET
admet-2774	206	7	successful	successful	ADJ
admet-2774	206	8	fabrication	fabrication	NOUN
admet-2774	206	9	of	of	ADP
admet-2774	206	10	polymeric	polymeric	ADJ
admet-2774	206	11	nanoparticles	nanoparticle	NOUN
admet-2774	206	12	for	for	ADP
admet-2774	206	13	drug	drug	NOUN
admet-2774	206	14	delivery	delivery	NOUN
admet-2774	206	15	with	with	ADP
admet-2774	206	16	optimal	optimal	ADJ
admet-2774	206	17	physicochemical	physicochemical	ADJ
admet-2774	206	18	properties	property	NOUN
admet-2774	206	19	for	for	ADP
admet-2774	206	20	sustained	sustained	ADJ
admet-2774	206	21	or	or	CCONJ
admet-2774	206	22	controlled	control	VERB
admet-2774	206	23	release	release	NOUN
admet-2774	206	24	.	.	PUNCT
admet-2774	207	1	in	in	ADP
admet-2774	207	2	-	-	PUNCT
admet-2774	207	3	vitro	vitro	X
admet-2774	207	4	aerosolization	aerosolization	NOUN
admet-2774	207	5	properties	property	NOUN
admet-2774	207	6	the	the	DET
admet-2774	207	7	aerosolization	aerosolization	NOUN
admet-2774	207	8	performance	performance	NOUN
admet-2774	207	9	of	of	ADP
admet-2774	207	10	inh	inh	NOUN
admet-2774	207	11	-	-	PUNCT
admet-2774	207	12	loaded	load	VERB
admet-2774	207	13	pcl	pcl	PROPN
admet-2774	207	14	nanoparticles	nanoparticle	NOUN
admet-2774	207	15	was	be	AUX
admet-2774	207	16	evaluated	evaluate	VERB
admet-2774	207	17	using	use	VERB
admet-2774	207	18	the	the	DET
admet-2774	207	19	ngi	ngi	PROPN
admet-2774	207	20	apparatus	apparatus	NOUN
admet-2774	207	21	.	.	PUNCT
admet-2774	208	1	the	the	DET
admet-2774	208	2	results	result	NOUN
admet-2774	208	3	of	of	ADP
admet-2774	208	4	the	the	DET
admet-2774	208	5	deposition	deposition	NOUN
admet-2774	208	6	pattern	pattern	NOUN
admet-2774	208	7	demonstrated	demonstrate	VERB
admet-2774	208	8	optimal	optimal	ADJ
admet-2774	208	9	particle	particle	NOUN
admet-2774	208	10	distribution	distribution	NOUN
admet-2774	208	11	,	,	PUNCT
admet-2774	208	12	with	with	ADP
admet-2774	208	13	most	most	ADJ
admet-2774	208	14	drug	drug	NOUN
admet-2774	208	15	depositions	deposition	NOUN
admet-2774	208	16	occurring	occur	VERB
admet-2774	208	17	below	below	ADP
admet-2774	208	18	stage	stage	NOUN
admet-2774	208	19	3	3	NUM
admet-2774	208	20	(	(	PUNCT
admet-2774	208	21	effective	effective	ADJ
admet-2774	208	22	cutoff	cutoff	NOUN
admet-2774	208	23	diameter	diameter	NOUN
admet-2774	208	24	<	<	X
admet-2774	208	25	4.7	4.7	NUM
admet-2774	208	26	µm	µm	NOUN
admet-2774	208	27	)	)	PUNCT
admet-2774	208	28	,	,	PUNCT
admet-2774	208	29	indicating	indicate	VERB
admet-2774	208	30	successful	successful	ADJ
admet-2774	208	31	targeting	targeting	NOUN
admet-2774	208	32	of	of	ADP
admet-2774	208	33	the	the	DET
admet-2774	208	34	bronchioalveolar	bronchioalveolar	ADJ
admet-2774	208	35	region	region	NOUN
admet-2774	208	36	where	where	SCONJ
admet-2774	208	37	mycobacteria	mycobacterium	NOUN
admet-2774	208	38	reside	reside	VERB
admet-2774	208	39	.	.	PUNCT
admet-2774	209	1	our	our	PRON
admet-2774	209	2	developed	develop	VERB
admet-2774	209	3	formulation	formulation	NOUN
admet-2774	209	4	exhibited	exhibit	VERB
admet-2774	209	5	favourable	favourable	ADJ
admet-2774	209	6	aerodynamic	aerodynamic	ADJ
admet-2774	209	7	characteristics	characteristic	NOUN
admet-2774	209	8	,	,	PUNCT
admet-2774	209	9	including	include	VERB
admet-2774	209	10	a	a	DET
admet-2774	209	11	mass	mass	ADJ
admet-2774	209	12	medium	medium	ADJ
admet-2774	209	13	aerodynamic	aerodynamic	ADJ
admet-2774	209	14	diameter	diameter	NOUN
admet-2774	209	15	(	(	PUNCT
admet-2774	209	16	mmad	mmad	NOUN
admet-2774	209	17	)	)	PUNCT
admet-2774	209	18	of	of	ADP
admet-2774	209	19	4.9	4.9	NUM
admet-2774	209	20	µm	µm	NOUN
admet-2774	209	21	,	,	PUNCT
admet-2774	209	22	which	which	PRON
admet-2774	209	23	falls	fall	VERB
admet-2774	209	24	within	within	ADP
admet-2774	209	25	the	the	DET
admet-2774	209	26	ideal	ideal	ADJ
admet-2774	209	27	1	1	NUM
admet-2774	209	28	-	-	SYM
admet-2774	209	29	5	5	NUM
admet-2774	209	30	µm	µm	NOUN
admet-2774	209	31	range	range	NOUN
admet-2774	209	32	for	for	ADP
admet-2774	209	33	efficient	efficient	ADJ
admet-2774	209	34	pulmonary	pulmonary	ADJ
admet-2774	209	35	delivery	delivery	NOUN
admet-2774	209	36	.	.	PUNCT
admet-2774	210	1	notably	notably	ADV
admet-2774	210	2	,	,	PUNCT
admet-2774	210	3	the	the	DET
admet-2774	210	4	fine	fine	ADJ
admet-2774	210	5	particle	particle	NOUN
admet-2774	210	6	fractions	fraction	NOUN
admet-2774	210	7	(	(	PUNCT
admet-2774	210	8	pfp	pfp	PROPN
admet-2774	210	9	)	)	PUNCT
admet-2774	210	10	reached	reach	VERB
admet-2774	210	11	40.1	40.1	NUM
admet-2774	210	12	%	%	NOUN
admet-2774	210	13	,	,	PUNCT
admet-2774	210	14	confirming	confirm	VERB
admet-2774	210	15	that	that	SCONJ
admet-2774	210	16	a	a	DET
admet-2774	210	17	substantial	substantial	ADJ
admet-2774	210	18	proportion	proportion	NOUN
admet-2774	210	19	of	of	ADP
admet-2774	210	20	particles	particle	NOUN
admet-2774	210	21	were	be	AUX
admet-2774	210	22	within	within	ADP
admet-2774	210	23	the	the	DET
admet-2774	210	24	respirable	respirable	ADJ
admet-2774	210	25	size	size	NOUN
admet-2774	210	26	ranges	range	VERB
admet-2774	210	27	(	(	PUNCT
admet-2774	210	28	<	<	X
admet-2774	210	29	5	5	NUM
admet-2774	210	30	µm	µm	NOUN
admet-2774	210	31	)	)	PUNCT
admet-2774	210	32	.	.	PUNCT
admet-2774	211	1	the	the	DET
admet-2774	211	2	high	high	ADJ
admet-2774	211	3	emitted	emitted	ADJ
admet-2774	211	4	dose	dose	NOUN
admet-2774	211	5	of	of	ADP
admet-2774	211	6	92.4	92.4	NUM
admet-2774	211	7	%	%	NOUN
admet-2774	211	8	further	far	ADV
admet-2774	211	9	demonstrated	demonstrate	VERB
admet-2774	211	10	excellent	excellent	ADJ
admet-2774	211	11	powder	powder	NOUN
admet-2774	211	12	dispersion	dispersion	NOUN
admet-2774	211	13	from	from	ADP
admet-2774	211	14	the	the	DET
admet-2774	211	15	delivery	delivery	NOUN
admet-2774	211	16	device	device	NOUN
admet-2774	211	17	.	.	PUNCT
admet-2774	212	1	the	the	DET
admet-2774	212	2	narrow	narrow	ADJ
admet-2774	212	3	gsd	gsd	NOUN
admet-2774	212	4	(	(	PUNCT
admet-2774	212	5	1.58	1.58	NUM
admet-2774	212	6	)	)	PUNCT
admet-2774	212	7	suggests	suggest	VERB
admet-2774	212	8	consistent	consistent	ADJ
admet-2774	212	9	particle	particle	NOUN
admet-2774	212	10	size	size	NOUN
admet-2774	212	11	distribution	distribution	NOUN
admet-2774	212	12	,	,	PUNCT
admet-2774	212	13	while	while	SCONJ
admet-2774	212	14	the	the	DET
admet-2774	212	15	mmad	mmad	NOUN
admet-2774	212	16	and	and	CCONJ
admet-2774	212	17	fpf	fpf	NOUN
admet-2774	212	18	demonstrate	demonstrate	NOUN
admet-2774	212	19	compatibility	compatibility	NOUN
admet-2774	212	20	with	with	ADP
admet-2774	212	21	deep	deep	ADJ
admet-2774	212	22	lung	lung	NOUN
admet-2774	212	23	delivery	delivery	NOUN
admet-2774	212	24	.	.	PUNCT
admet-2774	213	1	the	the	DET
admet-2774	213	2	deposition	deposition	NOUN
admet-2774	213	3	profile	profile	NOUN
admet-2774	213	4	,	,	PUNCT
admet-2774	213	5	illustrated	illustrate	VERB
admet-2774	213	6	in	in	ADP
admet-2774	213	7	figure	figure	NOUN
admet-2774	213	8	4	4	NUM
admet-2774	213	9	,	,	PUNCT
admet-2774	213	10	provides	provide	VERB
admet-2774	213	11	compressive	compressive	ADJ
admet-2774	213	12	evidence	evidence	NOUN
admet-2774	213	13	of	of	ADP
admet-2774	213	14	the	the	DET
admet-2774	213	15	formulation	formulation	NOUN
admet-2774	213	16	's	's	PART
admet-2774	213	17	suitability	suitability	NOUN
admet-2774	213	18	for	for	ADP
admet-2774	213	19	inhalation	inhalation	NOUN
admet-2774	213	20	therapy	therapy	NOUN
admet-2774	213	21	.	.	PUNCT
admet-2774	214	1	the	the	DET
admet-2774	214	2	collective	collective	ADJ
admet-2774	214	3	findings	finding	NOUN
admet-2774	214	4	validate	validate	VERB
admet-2774	214	5	that	that	SCONJ
admet-2774	214	6	the	the	DET
admet-2774	214	7	inh	inh	NOUN
admet-2774	214	8	-	-	PUNCT
admet-2774	214	9	loaded	load	VERB
admet-2774	214	10	pcl	pcl	PROPN
admet-2774	214	11	nanoparticle	nanoparticle	NOUN
admet-2774	214	12	formulations	formulation	NOUN
admet-2774	214	13	possess	possess	VERB
admet-2774	214	14	the	the	DET
admet-2774	214	15	necessary	necessary	ADJ
admet-2774	214	16	aerodynamic	aerodynamic	ADJ
admet-2774	214	17	properties	property	NOUN
admet-2774	214	18	for	for	ADP
admet-2774	214	19	effective	effective	ADJ
admet-2774	214	20	deep	deep	ADJ
admet-2774	214	21	lung	lung	NOUN
admet-2774	214	22	depositions	deposition	NOUN
admet-2774	214	23	,	,	PUNCT
admet-2774	214	24	making	make	VERB
admet-2774	214	25	them	they	PRON
admet-2774	214	26	promising	promise	VERB
admet-2774	214	27	candidates	candidate	NOUN
admet-2774	214	28	for	for	ADP
admet-2774	214	29	targeted	target	VERB
admet-2774	214	30	therapy	therapy	NOUN
admet-2774	214	31	against	against	ADP
admet-2774	214	32	pulmonary	pulmonary	ADJ
admet-2774	214	33	tuberculosis	tuberculosis	NOUN
admet-2774	214	34	.	.	PUNCT
admet-2774	215	1	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	215	2	e.	e.	PROPN
admet-2774	215	3	kole	kole	PROPN
admet-2774	215	4	et	et	PROPN
admet-2774	215	5	al	al	PROPN
admet-2774	215	6	.	.	PROPN
admet-2774	215	7	admet	admet	PROPN
admet-2774	215	8	&	&	CCONJ
admet-2774	215	9	dmpk	dmpk	PROPN
admet-2774	215	10	13(4	13(4	NUM
admet-2774	215	11	)	)	PUNCT
admet-2774	215	12	(	(	PUNCT
admet-2774	215	13	2025	2025	NUM
admet-2774	215	14	)	)	PUNCT
admet-2774	215	15	2774	2774	NUM
admet-2774	215	16	12	12	NUM
admet-2774	215	17	p	p	X
admet-2774	215	18	re	re	X
admet-2774	215	19	se	se	X
admet-2774	215	20	par	par	PROPN
admet-2774	215	21	at	at	ADP
admet-2774	215	22	or	or	CCONJ
admet-2774	215	23	s	s	AUX
admet-2774	215	24	ta	ta	ADP
admet-2774	215	25	ge	ge	PROPN
admet-2774	215	26	0	0	PROPN
admet-2774	215	27	s	s	AUX
admet-2774	215	28	ta	ta	X
admet-2774	215	29	ge	ge	PROPN
admet-2774	216	1	2	2	PROPN
admet-2774	216	2	s	s	PART
admet-2774	216	3	ta	ta	X
admet-2774	216	4	ge	ge	PROPN
admet-2774	217	1	3	3	PROPN
admet-2774	217	2	s	s	PART
admet-2774	217	3	ta	ta	X
admet-2774	217	4	ge	ge	PROPN
admet-2774	218	1	4	4	NUM
admet-2774	218	2	s	s	PART
admet-2774	218	3	ta	ta	X
admet-2774	218	4	ge	ge	PROPN
admet-2774	218	5	5	5	PROPN
admet-2774	218	6	s	s	PART
admet-2774	218	7	ta	ta	X
admet-2774	218	8	ge	ge	PROPN
admet-2774	218	9	6	6	NUM
admet-2774	218	10	s	s	AUX
admet-2774	218	11	ta	ta	X
admet-2774	218	12	ge	ge	PROPN
admet-2774	218	13	7	7	NUM
admet-2774	218	14	s	s	PART
admet-2774	218	15	ta	ta	X
admet-2774	218	16	ge8	ge8	NOUN
admet-2774	218	17	0	0	NUM
admet-2774	218	18	10	10	NUM
admet-2774	218	19	20	20	NUM
admet-2774	218	20	30	30	NUM
admet-2774	218	21	%	%	NOUN
admet-2774	218	22	d	d	NOUN
admet-2774	218	23	e	e	NOUN
admet-2774	218	24	p	p	NOUN
admet-2774	218	25	o	o	PROPN
admet-2774	218	26	s	s	X
admet-2774	218	27	s	s	X
admet-2774	218	28	it	it	PRON
admet-2774	218	29	io	io	NOUN
admet-2774	218	30	n	n	PRON
admet-2774	218	31	figure	figure	VERB
admet-2774	218	32	4	4	NUM
admet-2774	218	33	.	.	PUNCT
admet-2774	219	1	in	in	ADP
admet-2774	219	2	vitro	vitro	X
admet-2774	219	3	aerosolization	aerosolization	NOUN
admet-2774	219	4	behaviour	behaviour	NOUN
admet-2774	219	5	of	of	ADP
admet-2774	219	6	inh	inh	NOUN
admet-2774	219	7	-	-	PUNCT
admet-2774	219	8	loaded	load	VERB
admet-2774	219	9	pcl	pcl	PROPN
admet-2774	219	10	nanoparticles	nanoparticle	NOUN
admet-2774	219	11	in	in	ADP
admet-2774	219	12	-	-	PUNCT
admet-2774	219	13	vitro	vitro	X
admet-2774	219	14	drug	drug	NOUN
admet-2774	219	15	release	release	NOUN
admet-2774	219	16	study	study	NOUN
admet-2774	219	17	and	and	CCONJ
admet-2774	219	18	kinetic	kinetic	ADJ
admet-2774	219	19	study	study	NOUN
admet-2774	219	20	the	the	DET
admet-2774	219	21	in	in	X
admet-2774	219	22	vitro	vitro	X
admet-2774	219	23	drug	drug	NOUN
admet-2774	219	24	release	release	NOUN
admet-2774	219	25	profiles	profile	NOUN
admet-2774	219	26	of	of	ADP
admet-2774	219	27	pure	pure	ADJ
admet-2774	219	28	inh	inh	NOUN
admet-2774	219	29	and	and	CCONJ
admet-2774	219	30	inh	inh	NOUN
admet-2774	219	31	-	-	PUNCT
admet-2774	219	32	loaded	load	VERB
admet-2774	219	33	pcl	pcl	PROPN
admet-2774	219	34	nanoparticles	nanoparticle	NOUN
admet-2774	219	35	were	be	AUX
admet-2774	219	36	evaluated	evaluate	VERB
admet-2774	219	37	using	use	VERB
admet-2774	219	38	a	a	DET
admet-2774	219	39	dialysis	dialysis	NOUN
admet-2774	219	40	method	method	NOUN
admet-2774	219	41	in	in	ADP
admet-2774	219	42	pbs	pbs	PROPN
admet-2774	219	43	(	(	PUNCT
admet-2774	219	44	ph	ph	NOUN
admet-2774	219	45	7.4	7.4	NUM
admet-2774	219	46	)	)	PUNCT
admet-2774	219	47	.	.	PUNCT
admet-2774	220	1	pure	pure	ADJ
admet-2774	220	2	inh	inh	PROPN
admet-2774	220	3	exhibited	exhibit	VERB
admet-2774	220	4	a	a	DET
admet-2774	220	5	rapid	rapid	ADJ
admet-2774	220	6	release	release	NOUN
admet-2774	220	7	,	,	PUNCT
admet-2774	220	8	with	with	ADP
admet-2774	220	9	96.66	96.66	NUM
admet-2774	220	10	%	%	NOUN
admet-2774	220	11	of	of	ADP
admet-2774	220	12	the	the	DET
admet-2774	220	13	drug	drug	NOUN
admet-2774	220	14	released	release	VERB
admet-2774	220	15	within	within	ADP
admet-2774	220	16	the	the	DET
admet-2774	220	17	first	first	ADJ
admet-2774	220	18	2	2	NUM
admet-2774	220	19	h	h	NOUN
admet-2774	220	20	,	,	PUNCT
admet-2774	220	21	indicating	indicate	VERB
admet-2774	220	22	an	an	DET
admet-2774	220	23	immediate	immediate	ADJ
admet-2774	220	24	-	-	PUNCT
admet-2774	220	25	release	release	NOUN
admet-2774	220	26	profile	profile	NOUN
admet-2774	220	27	.	.	PUNCT
admet-2774	221	1	in	in	ADP
admet-2774	221	2	contrast	contrast	NOUN
admet-2774	221	3	,	,	PUNCT
admet-2774	221	4	the	the	DET
admet-2774	221	5	inh	inh	NOUN
admet-2774	221	6	-	-	PUNCT
admet-2774	221	7	loaded	load	VERB
admet-2774	221	8	pcl	pcl	PROPN
admet-2774	221	9	nanoformulation	nanoformulation	NOUN
admet-2774	221	10	showed	show	VERB
admet-2774	221	11	a	a	DET
admet-2774	221	12	sustained	sustained	ADJ
admet-2774	221	13	release	release	NOUN
admet-2774	221	14	pattern	pattern	NOUN
admet-2774	221	15	,	,	PUNCT
admet-2774	221	16	with	with	ADP
admet-2774	221	17	21.50	21.50	NUM
admet-2774	221	18	%	%	NOUN
admet-2774	221	19	released	release	VERB
admet-2774	221	20	at	at	ADP
admet-2774	221	21	2	2	NUM
admet-2774	221	22	h	h	NOUN
admet-2774	221	23	,	,	PUNCT
admet-2774	221	24	78.43	78.43	NUM
admet-2774	221	25	%	%	NOUN
admet-2774	221	26	at	at	ADP
admet-2774	221	27	24	24	NUM
admet-2774	221	28	h	h	NOUN
admet-2774	221	29	,	,	PUNCT
admet-2774	221	30	and	and	CCONJ
admet-2774	221	31	92.45	92.45	NUM
admet-2774	221	32	%	%	NOUN
admet-2774	221	33	over	over	ADP
admet-2774	221	34	48	48	NUM
admet-2774	221	35	h.	h.	NOUN
admet-2774	221	36	this	this	DET
admet-2774	221	37	extended	extend	VERB
admet-2774	221	38	-	-	PUNCT
admet-2774	221	39	release	release	NOUN
admet-2774	221	40	behaviour	behaviour	NOUN
admet-2774	221	41	highlights	highlight	VERB
admet-2774	221	42	the	the	DET
admet-2774	221	43	controlled	control	VERB
admet-2774	221	44	release	release	NOUN
admet-2774	221	45	capability	capability	NOUN
admet-2774	221	46	of	of	ADP
admet-2774	221	47	the	the	DET
admet-2774	221	48	pcl	pcl	PROPN
admet-2774	221	49	nanoparticle	nanoparticle	NOUN
admet-2774	221	50	matrix	matrix	NOUN
admet-2774	221	51	,	,	PUNCT
admet-2774	221	52	which	which	PRON
admet-2774	221	53	can	can	AUX
admet-2774	221	54	help	help	VERB
admet-2774	221	55	maintain	maintain	VERB
admet-2774	221	56	therapeutic	therapeutic	ADJ
admet-2774	221	57	drug	drug	NOUN
admet-2774	221	58	levels	level	NOUN
admet-2774	221	59	over	over	ADP
admet-2774	221	60	a	a	DET
admet-2774	221	61	prolonged	prolonged	ADJ
admet-2774	221	62	period	period	NOUN
admet-2774	221	63	.	.	PUNCT
admet-2774	222	1	such	such	DET
admet-2774	222	2	a	a	DET
admet-2774	222	3	release	release	NOUN
admet-2774	222	4	profile	profile	NOUN
admet-2774	222	5	offers	offer	VERB
admet-2774	222	6	significant	significant	ADJ
admet-2774	222	7	therapeutic	therapeutic	ADJ
admet-2774	222	8	advantages	advantage	NOUN
admet-2774	222	9	,	,	PUNCT
admet-2774	222	10	including	include	VERB
admet-2774	222	11	reduced	reduce	VERB
admet-2774	222	12	dosing	dose	VERB
admet-2774	222	13	frequency	frequency	NOUN
admet-2774	222	14	and	and	CCONJ
admet-2774	222	15	improved	improve	VERB
admet-2774	222	16	patient	patient	ADJ
admet-2774	222	17	compliance	compliance	NOUN
admet-2774	222	18	compared	compare	VERB
admet-2774	222	19	to	to	ADP
admet-2774	222	20	conventional	conventional	ADJ
admet-2774	222	21	formulations	formulation	NOUN
admet-2774	222	22	.	.	PUNCT
admet-2774	223	1	(	(	PUNCT
admet-2774	223	2	figure	figure	NOUN
admet-2774	223	3	5a	5a	NUM
admet-2774	223	4	)	)	PUNCT
admet-2774	223	5	the	the	DET
admet-2774	223	6	drug	drug	NOUN
admet-2774	223	7	release	release	NOUN
admet-2774	223	8	behaviour	behaviour	NOUN
admet-2774	223	9	of	of	ADP
admet-2774	223	10	inh	inh	NOUN
admet-2774	223	11	-	-	PUNCT
admet-2774	223	12	loaded	load	VERB
admet-2774	223	13	pcl	pcl	PROPN
admet-2774	223	14	nanoparticles	nanoparticle	NOUN
admet-2774	223	15	was	be	AUX
admet-2774	223	16	analysed	analyse	VERB
admet-2774	223	17	using	use	VERB
admet-2774	223	18	various	various	ADJ
admet-2774	223	19	kinetic	kinetic	ADJ
admet-2774	223	20	models	model	NOUN
admet-2774	223	21	,	,	PUNCT
admet-2774	223	22	including	include	VERB
admet-2774	223	23	zero	zero	NUM
admet-2774	223	24	-	-	PUNCT
admet-2774	223	25	order	order	NOUN
admet-2774	223	26	,	,	PUNCT
admet-2774	223	27	first	first	ADJ
admet-2774	223	28	-	-	PUNCT
admet-2774	223	29	order	order	NOUN
admet-2774	223	30	,	,	PUNCT
admet-2774	223	31	higuchi	higuchi	ADJ
admet-2774	223	32	,	,	PUNCT
admet-2774	223	33	hixsoncrowell	hixsoncrowell	NOUN
admet-2774	223	34	,	,	PUNCT
admet-2774	223	35	and	and	CCONJ
admet-2774	223	36	korsmeyer	korsmeyer	NOUN
admet-2774	223	37	-	-	PUNCT
admet-2774	223	38	peppas	peppas	NOUN
admet-2774	223	39	models	model	NOUN
admet-2774	223	40	.	.	PUNCT
admet-2774	224	1	(	(	PUNCT
admet-2774	224	2	figures	figure	NOUN
admet-2774	224	3	5b-5f	5b-5f	NUM
admet-2774	224	4	)	)	PUNCT
admet-2774	224	5	among	among	ADP
admet-2774	224	6	these	these	PRON
admet-2774	224	7	,	,	PUNCT
admet-2774	224	8	the	the	DET
admet-2774	224	9	first	first	ADJ
admet-2774	224	10	-	-	PUNCT
admet-2774	224	11	order	order	NOUN
admet-2774	224	12	model	model	NOUN
admet-2774	224	13	exhibited	exhibit	VERB
admet-2774	224	14	the	the	DET
admet-2774	224	15	highest	high	ADJ
admet-2774	224	16	correlation	correlation	NOUN
admet-2774	224	17	coefficient	coefficient	NOUN
admet-2774	224	18	(	(	PUNCT
admet-2774	224	19	r²	r²	NOUN
admet-2774	224	20	=	=	NOUN
admet-2774	224	21	0.9750	0.9750	NUM
admet-2774	224	22	)	)	PUNCT
admet-2774	224	23	,	,	PUNCT
admet-2774	224	24	indicating	indicate	VERB
admet-2774	224	25	that	that	SCONJ
admet-2774	224	26	the	the	DET
admet-2774	224	27	release	release	NOUN
admet-2774	224	28	rate	rate	NOUN
admet-2774	224	29	depends	depend	VERB
admet-2774	224	30	on	on	ADP
admet-2774	224	31	the	the	DET
admet-2774	224	32	remaining	remain	VERB
admet-2774	224	33	drug	drug	NOUN
admet-2774	224	34	concentration	concentration	NOUN
admet-2774	224	35	and	and	CCONJ
admet-2774	224	36	follows	follow	VERB
admet-2774	224	37	a	a	DET
admet-2774	224	38	concentration	concentration	NOUN
admet-2774	224	39	-	-	PUNCT
admet-2774	224	40	gradient	gradient	NOUN
admet-2774	224	41	-	-	PUNCT
admet-2774	224	42	driven	drive	VERB
admet-2774	224	43	mechanism	mechanism	NOUN
admet-2774	224	44	.	.	PUNCT
admet-2774	225	1	the	the	DET
admet-2774	225	2	zero	zero	NUM
admet-2774	225	3	-	-	PUNCT
admet-2774	225	4	order	order	NOUN
admet-2774	225	5	(	(	PUNCT
admet-2774	225	6	r²	r²	NOUN
admet-2774	225	7	=	=	SYM
admet-2774	225	8	0.911	0.911	NUM
admet-2774	225	9	)	)	PUNCT
admet-2774	225	10	and	and	CCONJ
admet-2774	225	11	hixson	hixson	PROPN
admet-2774	225	12	-	-	PUNCT
admet-2774	225	13	crowell	crowell	PROPN
admet-2774	225	14	(	(	PUNCT
admet-2774	225	15	r²	r²	NOUN
admet-2774	225	16	=	=	SYM
admet-2774	225	17	0.9587	0.9587	NUM
admet-2774	225	18	)	)	PUNCT
admet-2774	225	19	models	model	NOUN
admet-2774	225	20	also	also	ADV
admet-2774	225	21	showed	show	VERB
admet-2774	225	22	good	good	ADJ
admet-2774	225	23	fits	fit	NOUN
admet-2774	225	24	,	,	PUNCT
admet-2774	225	25	suggesting	suggest	VERB
admet-2774	225	26	a	a	DET
admet-2774	225	27	controlled	control	VERB
admet-2774	225	28	release	release	NOUN
admet-2774	225	29	profile	profile	NOUN
admet-2774	225	30	possibly	possibly	ADV
admet-2774	225	31	influenced	influence	VERB
admet-2774	225	32	by	by	ADP
admet-2774	225	33	surface	surface	NOUN
admet-2774	225	34	area	area	NOUN
admet-2774	225	35	reduction	reduction	NOUN
admet-2774	225	36	and	and	CCONJ
admet-2774	225	37	matrix	matrix	NOUN
admet-2774	225	38	erosion	erosion	NOUN
admet-2774	225	39	.	.	PUNCT
admet-2774	226	1	the	the	DET
admet-2774	226	2	higuchi	higuchi	PROPN
admet-2774	226	3	model	model	NOUN
admet-2774	226	4	(	(	PUNCT
admet-2774	226	5	r²	r²	NOUN
admet-2774	226	6	=	=	SYM
admet-2774	226	7	0.9259	0.9259	NUM
admet-2774	226	8	)	)	PUNCT
admet-2774	226	9	revealed	reveal	VERB
admet-2774	226	10	diffusionbased	diffusionbase	VERB
admet-2774	226	11	release	release	NOUN
admet-2774	226	12	through	through	ADP
admet-2774	226	13	the	the	DET
admet-2774	226	14	polymer	polymer	NOUN
admet-2774	226	15	matrix	matrix	NOUN
admet-2774	226	16	(	(	PUNCT
admet-2774	226	17	table	table	NOUN
admet-2774	226	18	5	5	NUM
admet-2774	226	19	)	)	PUNCT
admet-2774	226	20	.	.	PUNCT
admet-2774	227	1	the	the	DET
admet-2774	227	2	kinetic	kinetic	ADJ
admet-2774	227	3	constant	constant	ADJ
admet-2774	227	4	(	(	PUNCT
admet-2774	227	5	k	k	NOUN
admet-2774	227	6	)	)	PUNCT
admet-2774	227	7	was	be	AUX
admet-2774	227	8	determined	determine	VERB
admet-2774	227	9	to	to	PART
admet-2774	227	10	be	be	AUX
admet-2774	227	11	3.9548	3.9548	NUM
admet-2774	227	12	,	,	PUNCT
admet-2774	227	13	while	while	SCONJ
admet-2774	227	14	the	the	DET
admet-2774	227	15	release	release	NOUN
admet-2774	227	16	exponent	exponent	NOUN
admet-2774	227	17	(	(	PUNCT
admet-2774	227	18	n	n	CCONJ
admet-2774	227	19	)	)	PUNCT
admet-2774	227	20	of	of	ADP
admet-2774	227	21	the	the	DET
admet-2774	227	22	korsmeyer	korsmeyer	NOUN
admet-2774	227	23	-	-	PUNCT
admet-2774	227	24	peppas	peppa	NOUN
admet-2774	227	25	equation	equation	NOUN
admet-2774	227	26	was	be	AUX
admet-2774	227	27	found	find	VERB
admet-2774	227	28	to	to	PART
admet-2774	227	29	be	be	AUX
admet-2774	227	30	6.6785	6.6785	NUM
admet-2774	227	31	.	.	PUNCT
admet-2774	228	1	the	the	DET
admet-2774	228	2	high	high	ADJ
admet-2774	228	3	value	value	NOUN
admet-2774	228	4	of	of	ADP
admet-2774	228	5	the	the	DET
admet-2774	228	6	release	release	NOUN
admet-2774	228	7	exponents	exponent	NOUN
admet-2774	228	8	(	(	PUNCT
admet-2774	228	9	n	n	X
admet-2774	228	10	>	>	NOUN
admet-2774	228	11	0.89	0.89	NUM
admet-2774	228	12	)	)	PUNCT
admet-2774	228	13	indicates	indicate	VERB
admet-2774	228	14	that	that	SCONJ
admet-2774	228	15	super	super	ADJ
admet-2774	228	16	case	case	NOUN
admet-2774	228	17	ii	ii	NOUN
admet-2774	228	18	transport	transport	NOUN
admet-2774	228	19	(	(	PUNCT
admet-2774	228	20	non	non	ADJ
admet-2774	228	21	-	-	ADJ
admet-2774	228	22	fickian	fickian	ADJ
admet-2774	228	23	diffusion	diffusion	NOUN
admet-2774	228	24	)	)	PUNCT
admet-2774	228	25	governs	govern	VERB
admet-2774	228	26	the	the	DET
admet-2774	228	27	drug	drug	NOUN
admet-2774	228	28	release	release	NOUN
admet-2774	228	29	.	.	PUNCT
admet-2774	229	1	these	these	DET
admet-2774	229	2	findings	finding	NOUN
admet-2774	229	3	strongly	strongly	ADV
admet-2774	229	4	suggest	suggest	VERB
admet-2774	229	5	that	that	SCONJ
admet-2774	229	6	the	the	DET
admet-2774	229	7	dominant	dominant	ADJ
admet-2774	229	8	release	release	NOUN
admet-2774	229	9	mechanism	mechanism	NOUN
admet-2774	229	10	involves	involve	VERB
admet-2774	229	11	substantial	substantial	ADJ
admet-2774	229	12	polymer	polymer	NOUN
admet-2774	229	13	relaxation	relaxation	NOUN
admet-2774	229	14	and	and	CCONJ
admet-2774	229	15	matrix	matrix	NOUN
admet-2774	229	16	swelling	swelling	NOUN
admet-2774	229	17	effects	effect	NOUN
admet-2774	229	18	,	,	PUNCT
admet-2774	229	19	rather	rather	ADV
admet-2774	229	20	than	than	ADP
admet-2774	229	21	simple	simple	ADJ
admet-2774	229	22	diffusion	diffusion	NOUN
admet-2774	229	23	-	-	PUNCT
admet-2774	229	24	controlled	control	VERB
admet-2774	229	25	release	release	NOUN
admet-2774	229	26	[	[	X
admet-2774	229	27	45	45	NUM
admet-2774	229	28	]	]	PUNCT
admet-2774	229	29	.	.	PUNCT
admet-2774	230	1	table	table	NOUN
admet-2774	230	2	5	5	NUM
admet-2774	230	3	.	.	PUNCT
admet-2774	230	4	release	release	VERB
admet-2774	230	5	kinetic	kinetic	NOUN
admet-2774	230	6	models	model	NOUN
admet-2774	230	7	of	of	ADP
admet-2774	230	8	inh	inh	NOUN
admet-2774	230	9	-	-	PUNCT
admet-2774	230	10	loaded	load	VERB
admet-2774	230	11	pcl	pcl	PROPN
admet-2774	230	12	nanoparticles	nanoparticle	NOUN
admet-2774	230	13	model	model	VERB
admet-2774	230	14	inh	inh	PROPN
admet-2774	230	15	-	-	PUNCT
admet-2774	230	16	loaded	load	VERB
admet-2774	230	17	pcl	pcl	PROPN
admet-2774	230	18	nanoparticles	nanoparticle	NOUN
admet-2774	230	19	r2	r2	PROPN
admet-2774	230	20	k	k	PROPN
admet-2774	230	21	n	n	PROPN
admet-2774	230	22	zero	zero	NUM
admet-2774	230	23	order	order	NOUN
admet-2774	230	24	0.9110	0.9110	PROPN
admet-2774	230	25	3.9548	3.9548	NUM
admet-2774	230	26	5.7665	5.7665	NUM
admet-2774	230	27	first	first	ADJ
admet-2774	230	28	order	order	NOUN
admet-2774	230	29	0.9750	0.9750	NUM
admet-2774	230	30	0.0295	0.0295	NUM
admet-2774	230	31	1.9967	1.9967	NUM
admet-2774	230	32	higuchi	higuchi	ADJ
admet-2774	230	33	model	model	NOUN
admet-2774	230	34	0.9259	0.9259	NUM
admet-2774	230	35	18.046	18.046	NUM
admet-2774	230	36	8.2321	8.2321	NUM
admet-2774	230	37	hixson	hixson	PROPN
admet-2774	230	38	-	-	PUNCT
admet-2774	230	39	crowell	crowell	PROPN
admet-2774	230	40	model	model	NOUN
admet-2774	230	41	0.9587	0.9587	NUM
admet-2774	230	42	0.0869	0.0869	NUM
admet-2774	230	43	0.0476	0.0476	NUM
admet-2774	230	44	korsmeyer	korsmeyer	NOUN
admet-2774	230	45	-	-	PUNCT
admet-2774	230	46	peppas	peppas	NOUN
admet-2774	230	47	model	model	NOUN
admet-2774	230	48	0.9630	0.9630	NUM
admet-2774	230	49	58.395	58.395	NUM
admet-2774	230	50	6.6785	6.6785	NUM
admet-2774	231	1	d	d	NOUN
admet-2774	231	2	ep	ep	PROPN
admet-2774	231	3	o	o	NOUN
admet-2774	231	4	si	si	INTJ
admet-2774	231	5	ti	ti	X
admet-2774	231	6	o	o	NOUN
admet-2774	231	7	n	n	PROPN
admet-2774	231	8	,	,	PUNCT
admet-2774	231	9	%	%	INTJ
admet-2774	231	10	admet	admet	PROPN
admet-2774	231	11	&	&	CCONJ
admet-2774	231	12	dmpk	dmpk	PROPN
admet-2774	231	13	13(4	13(4	NUM
admet-2774	231	14	)	)	PUNCT
admet-2774	231	15	(	(	PUNCT
admet-2774	231	16	2025	2025	NUM
admet-2774	231	17	)	)	PUNCT
admet-2774	231	18	2774	2774	NUM
admet-2774	231	19	freeze	freeze	NOUN
admet-2774	231	20	-	-	PUNCT
admet-2774	231	21	dried	dry	VERB
admet-2774	231	22	isoniazid	isoniazid	NOUN
admet-2774	231	23	-	-	PUNCT
admet-2774	231	24	loaded	load	VERB
admet-2774	231	25	poly	poly	ADJ
admet-2774	231	26	-	-	PUNCT
admet-2774	231	27	ε	ε	NOUN
admet-2774	231	28	-	-	PUNCT
admet-2774	231	29	caprolactone	caprolactone	ADJ
admet-2774	231	30	nanoparticles	nanoparticle	NOUN
admet-2774	231	31	doi	doi	NOUN
admet-2774	231	32	:	:	PUNCT
admet-2774	231	33	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	231	34	13	13	NUM
admet-2774	231	35	overall	overall	NOUN
admet-2774	231	36	,	,	PUNCT
admet-2774	231	37	the	the	DET
admet-2774	231	38	findings	finding	NOUN
admet-2774	231	39	indicate	indicate	VERB
admet-2774	231	40	that	that	SCONJ
admet-2774	231	41	inh	inh	PROPN
admet-2774	231	42	release	release	NOUN
admet-2774	231	43	from	from	ADP
admet-2774	231	44	the	the	DET
admet-2774	231	45	nanoparticles	nanoparticle	NOUN
admet-2774	231	46	is	be	AUX
admet-2774	231	47	primarily	primarily	ADV
admet-2774	231	48	governed	govern	VERB
admet-2774	231	49	by	by	ADP
admet-2774	231	50	first	first	ADJ
admet-2774	231	51	-	-	PUNCT
admet-2774	231	52	order	order	NOUN
admet-2774	231	53	kinetics	kinetic	NOUN
admet-2774	231	54	,	,	PUNCT
admet-2774	231	55	with	with	ADP
admet-2774	231	56	additional	additional	ADJ
admet-2774	231	57	contributions	contribution	NOUN
admet-2774	231	58	from	from	ADP
admet-2774	231	59	diffusion	diffusion	NOUN
admet-2774	231	60	and	and	CCONJ
admet-2774	231	61	polymer	polymer	NOUN
admet-2774	231	62	degradation	degradation	NOUN
admet-2774	231	63	processes	process	NOUN
admet-2774	231	64	,	,	PUNCT
admet-2774	231	65	supporting	support	VERB
admet-2774	231	66	its	its	PRON
admet-2774	231	67	potential	potential	NOUN
admet-2774	231	68	for	for	ADP
admet-2774	231	69	sustained	sustained	ADJ
admet-2774	231	70	drug	drug	NOUN
admet-2774	231	71	delivery	delivery	NOUN
admet-2774	231	72	.	.	PUNCT
admet-2774	232	1	log	log	NOUN
admet-2774	232	2	(	(	PUNCT
admet-2774	232	3	time	time	NOUN
admet-2774	232	4	,	,	PUNCT
admet-2774	232	5	h	h	NOUN
admet-2774	232	6	)	)	PUNCT
admet-2774	232	7	time	time	NOUN
admet-2774	232	8	,	,	PUNCT
admet-2774	232	9	h	h	NOUN
admet-2774	232	10	figure	figure	NOUN
admet-2774	232	11	5	5	NUM
admet-2774	232	12	.	.	PUNCT
admet-2774	233	1	in	in	ADP
admet-2774	233	2	vitro	vitro	X
admet-2774	233	3	drug	drug	NOUN
admet-2774	233	4	release	release	NOUN
admet-2774	233	5	and	and	CCONJ
admet-2774	233	6	kinetic	kinetic	ADJ
admet-2774	233	7	study	study	NOUN
admet-2774	233	8	.	.	PUNCT
admet-2774	234	1	(	(	PUNCT
admet-2774	234	2	a	a	X
admet-2774	234	3	)	)	PUNCT
admet-2774	234	4	cumulative	cumulative	ADJ
admet-2774	234	5	release	release	NOUN
admet-2774	234	6	of	of	ADP
admet-2774	234	7	pure	pure	ADJ
admet-2774	234	8	inh	inh	NOUN
admet-2774	234	9	and	and	CCONJ
admet-2774	234	10	inh	inh	NOUN
admet-2774	234	11	-	-	PUNCT
admet-2774	234	12	loaded	load	VERB
admet-2774	234	13	pcl	pcl	PROPN
admet-2774	234	14	nanoparticles	nanoparticle	NOUN
admet-2774	234	15	(	(	PUNCT
admet-2774	234	16	n	n	NOUN
admet-2774	234	17	=	=	SYM
admet-2774	234	18	3	3	NUM
admet-2774	234	19	;	;	PUNCT
admet-2774	234	20	mean	mean	PROPN
admet-2774	234	21	±	±	NUM
admet-2774	234	22	sd	sd	NOUN
admet-2774	234	23	)	)	PUNCT
admet-2774	234	24	.	.	PUNCT
admet-2774	235	1	release	release	NOUN
admet-2774	235	2	kinetics	kinetic	NOUN
admet-2774	235	3	fitted	fit	VERB
admet-2774	235	4	to	to	ADP
admet-2774	235	5	(	(	PUNCT
admet-2774	235	6	b	b	NOUN
admet-2774	235	7	)	)	PUNCT
admet-2774	235	8	higuchi	higuchi	ADJ
admet-2774	235	9	,	,	PUNCT
admet-2774	235	10	(	(	PUNCT
admet-2774	235	11	c	c	NOUN
admet-2774	235	12	)	)	PUNCT
admet-2774	235	13	zero	zero	NUM
admet-2774	235	14	-	-	PUNCT
admet-2774	235	15	order	order	NOUN
admet-2774	235	16	,	,	PUNCT
admet-2774	235	17	(	(	PUNCT
admet-2774	235	18	d	d	X
admet-2774	235	19	)	)	PUNCT
admet-2774	235	20	first	first	ADJ
admet-2774	235	21	-	-	PUNCT
admet-2774	235	22	order	order	NOUN
admet-2774	235	23	,	,	PUNCT
admet-2774	235	24	(	(	PUNCT
admet-2774	235	25	e	e	NOUN
admet-2774	235	26	)	)	PUNCT
admet-2774	235	27	korsmeyer	korsmeyer	NOUN
admet-2774	235	28	-	-	PUNCT
admet-2774	235	29	peppas	peppa	NOUN
admet-2774	235	30	and	and	CCONJ
admet-2774	235	31	(	(	PUNCT
admet-2774	235	32	f	f	X
admet-2774	235	33	)	)	PUNCT
admet-2774	235	34	hixson	hixson	PROPN
admet-2774	235	35	-	-	PUNCT
admet-2774	235	36	crowell	crowell	PROPN
admet-2774	235	37	models	model	NOUN
admet-2774	235	38	.	.	PUNCT
admet-2774	236	1	(	(	PUNCT
admet-2774	236	2	cbr	cbr	PROPN
admet-2774	236	3	cumulative	cumulative	ADJ
admet-2774	236	4	burst	burst	NOUN
admet-2774	236	5	release	release	NOUN
admet-2774	236	6	,	,	PUNCT
admet-2774	236	7	wo	will	AUX
admet-2774	236	8	initial	initial	ADJ
admet-2774	236	9	weight	weight	NOUN
admet-2774	236	10	,	,	PUNCT
admet-2774	236	11	and	and	CCONJ
admet-2774	236	12	wt	wt	ADP
admet-2774	236	13	weight	weight	NOUN
admet-2774	236	14	at	at	ADP
admet-2774	236	15	time	time	NOUN
admet-2774	236	16	)	)	PUNCT
admet-2774	236	17	stability	stability	NOUN
admet-2774	236	18	study	study	VERB
admet-2774	236	19	the	the	DET
admet-2774	236	20	long	long	ADJ
admet-2774	236	21	-	-	PUNCT
admet-2774	236	22	term	term	NOUN
admet-2774	236	23	stability	stability	NOUN
admet-2774	236	24	of	of	ADP
admet-2774	236	25	lyophilized	lyophilized	ADJ
admet-2774	236	26	inh	inh	PROPN
admet-2774	236	27	-	-	PUNCT
admet-2774	236	28	loaded	load	VERB
admet-2774	236	29	pcl	pcl	PROPN
admet-2774	236	30	nanoparticles	nanoparticle	NOUN
admet-2774	236	31	was	be	AUX
admet-2774	236	32	evaluated	evaluate	VERB
admet-2774	236	33	under	under	ADP
admet-2774	236	34	controlled	control	VERB
admet-2774	236	35	storage	storage	NOUN
admet-2774	236	36	conditions	condition	NOUN
admet-2774	236	37	(	(	PUNCT
admet-2774	236	38	25±2	25±2	NOUN
admet-2774	236	39	 	 	SPACE
admet-2774	236	40	°	°	ADP
admet-2774	236	41	c	c	NOUN
admet-2774	236	42	)	)	PUNCT
admet-2774	236	43	for	for	ADP
admet-2774	236	44	six	six	NUM
admet-2774	236	45	months	month	NOUN
admet-2774	236	46	.	.	PUNCT
admet-2774	237	1	throughout	throughout	ADP
admet-2774	237	2	the	the	DET
admet-2774	237	3	study	study	NOUN
admet-2774	237	4	period	period	NOUN
admet-2774	237	5	,	,	PUNCT
admet-2774	237	6	key	key	ADJ
admet-2774	237	7	physicochemical	physicochemical	ADJ
admet-2774	237	8	properties	property	NOUN
admet-2774	237	9	,	,	PUNCT
admet-2774	237	10	such	such	ADJ
admet-2774	237	11	as	as	ADP
admet-2774	237	12	particle	particle	NOUN
admet-2774	237	13	size	size	NOUN
admet-2774	237	14	,	,	PUNCT
admet-2774	237	15	zeta	zeta	NOUN
admet-2774	237	16	potential	potential	NOUN
admet-2774	237	17	,	,	PUNCT
admet-2774	237	18	and	and	CCONJ
admet-2774	237	19	pdi	pdi	PROPN
admet-2774	237	20	,	,	PUNCT
admet-2774	237	21	remained	remain	VERB
admet-2774	237	22	within	within	ADP
admet-2774	237	23	acceptable	acceptable	ADJ
admet-2774	237	24	ranges	range	NOUN
admet-2774	237	25	(	(	PUNCT
admet-2774	237	26	p	p	X
admet-2774	237	27	>	>	X
admet-2774	237	28	0.05	0.05	NUM
admet-2774	237	29	)	)	PUNCT
admet-2774	237	30	,	,	PUNCT
admet-2774	237	31	indicating	indicate	VERB
admet-2774	237	32	no	no	DET
admet-2774	237	33	significant	significant	ADJ
admet-2774	237	34	variations	variation	NOUN
admet-2774	237	35	.	.	PUNCT
admet-2774	238	1	the	the	DET
admet-2774	238	2	formulation	formulation	NOUN
admet-2774	238	3	also	also	ADV
admet-2774	238	4	maintained	maintain	VERB
admet-2774	238	5	its	its	PRON
admet-2774	238	6	structural	structural	ADJ
admet-2774	238	7	integrity	integrity	NOUN
admet-2774	238	8	,	,	PUNCT
admet-2774	238	9	with	with	ADP
admet-2774	238	10	no	no	DET
admet-2774	238	11	visible	visible	ADJ
admet-2774	238	12	changes	change	NOUN
admet-2774	238	13	observed	observe	VERB
admet-2774	238	14	in	in	ADP
admet-2774	238	15	its	its	PRON
admet-2774	238	16	appearance	appearance	NOUN
admet-2774	238	17	.	.	PUNCT
admet-2774	239	1	these	these	DET
admet-2774	239	2	findings	finding	NOUN
admet-2774	239	3	demonstrate	demonstrate	VERB
admet-2774	239	4	that	that	SCONJ
admet-2774	239	5	the	the	DET
admet-2774	239	6	nanoformulation	nanoformulation	NOUN
admet-2774	239	7	remains	remain	VERB
admet-2774	239	8	stable	stable	ADJ
admet-2774	239	9	under	under	ADP
admet-2774	239	10	ambient	ambient	ADJ
admet-2774	239	11	storage	storage	NOUN
admet-2774	239	12	conditions	condition	NOUN
admet-2774	239	13	(	(	PUNCT
admet-2774	239	14	figure	figure	VERB
admet-2774	239	15	6a	6a	NOUN
admet-2774	239	16	and	and	CCONJ
admet-2774	239	17	b	b	NOUN
admet-2774	239	18	)	)	PUNCT
admet-2774	239	19	.	.	PUNCT
admet-2774	240	1	lo	lo	PROPN
admet-2774	240	2	g	g	PROPN
admet-2774	240	3	(	(	PUNCT
admet-2774	240	4	c	c	NOUN
admet-2774	240	5	u	u	NOUN
admet-2774	240	6	m	m	NOUN
admet-2774	240	7	u	u	VERB
admet-2774	240	8	la	la	X
admet-2774	240	9	ti	ti	X
admet-2774	240	10	ve	ve	PROPN
admet-2774	240	11	d	d	PROPN
admet-2774	240	12	ru	ru	PROPN
admet-2774	240	13	g	g	PROPN
admet-2774	240	14	re	re	ADP
admet-2774	240	15	le	le	NOUN
admet-2774	240	16	as	as	ADP
admet-2774	240	17	e	e	PROPN
admet-2774	240	18	,	,	PUNCT
admet-2774	240	19	%	%	INTJ
admet-2774	240	20	)	)	PUNCT
admet-2774	240	21	c	c	VERB
admet-2774	240	22	u	u	NOUN
admet-2774	240	23	m	m	VERB
admet-2774	240	24	u	u	VERB
admet-2774	240	25	la	la	X
admet-2774	240	26	ti	ti	X
admet-2774	240	27	ve	ve	PROPN
admet-2774	240	28	d	d	PROPN
admet-2774	240	29	ru	ru	PROPN
admet-2774	240	30	g	g	PROPN
admet-2774	240	31	re	re	ADP
admet-2774	240	32	le	le	X
admet-2774	240	33	as	as	ADP
admet-2774	240	34	e	e	PROPN
admet-2774	240	35	,	,	PUNCT
admet-2774	240	36	%	%	INTJ
admet-2774	240	37	c	c	NOUN
admet-2774	240	38	u	u	VERB
admet-2774	240	39	m	m	VERB
admet-2774	240	40	u	u	VERB
admet-2774	240	41	la	la	X
admet-2774	240	42	ti	ti	X
admet-2774	240	43	ve	ve	PROPN
admet-2774	240	44	d	d	PROPN
admet-2774	240	45	ru	ru	PROPN
admet-2774	240	46	g	g	PROPN
admet-2774	240	47	re	re	ADP
admet-2774	240	48	le	le	X
admet-2774	240	49	as	as	ADP
admet-2774	240	50	e	e	PROPN
admet-2774	240	51	,	,	PUNCT
admet-2774	240	52	%	%	INTJ
admet-2774	240	53	c	c	NOUN
admet-2774	240	54	u	u	VERB
admet-2774	240	55	m	m	VERB
admet-2774	240	56	u	u	VERB
admet-2774	240	57	la	la	X
admet-2774	240	58	ti	ti	X
admet-2774	240	59	ve	ve	PROPN
admet-2774	240	60	d	d	PROPN
admet-2774	240	61	ru	ru	PROPN
admet-2774	240	62	g	g	PROPN
admet-2774	240	63	re	re	ADP
admet-2774	240	64	le	le	X
admet-2774	240	65	as	as	ADP
admet-2774	240	66	e	e	PROPN
admet-2774	240	67	,	,	PUNCT
admet-2774	240	68	%	%	INTJ
admet-2774	241	1	lo	lo	PROPN
admet-2774	241	2	g	g	PROPN
admet-2774	241	3	(	(	PUNCT
admet-2774	241	4	c	c	NOUN
admet-2774	241	5	u	u	NOUN
admet-2774	241	6	m	m	NOUN
admet-2774	241	7	u	u	VERB
admet-2774	241	8	la	la	X
admet-2774	241	9	ti	ti	X
admet-2774	241	10	ve	ve	PROPN
admet-2774	241	11	d	d	PROPN
admet-2774	241	12	ru	ru	PROPN
admet-2774	241	13	g	g	PROPN
admet-2774	241	14	re	re	VERB
admet-2774	241	15	m	m	PROPN
admet-2774	241	16	ai	ai	VERB
admet-2774	241	17	n	n	ADV
admet-2774	241	18	in	in	ADP
admet-2774	241	19	g	g	PROPN
admet-2774	241	20	,	,	PUNCT
admet-2774	241	21	%	%	NOUN
admet-2774	241	22	)	)	PUNCT
admet-2774	242	1	c	c	PROPN
admet-2774	243	1	b	b	X
admet-2774	243	2	r	r	NOUN
admet-2774	243	3	(	(	PUNCT
admet-2774	243	4	w	w	NOUN
admet-2774	243	5	o	o	NOUN
admet-2774	243	6	)	)	PUNCT
admet-2774	244	1	c	c	PROPN
admet-2774	245	1	b	b	X
admet-2774	245	2	r	r	NOUN
admet-2774	245	3	(	(	PUNCT
admet-2774	245	4	w	w	PROPN
admet-2774	245	5	t	t	PROPN
admet-2774	245	6	)	)	PUNCT
admet-2774	245	7	,	,	PUNCT
admet-2774	245	8	%	%	NOUN
admet-2774	245	9	time	time	NOUN
admet-2774	245	10	,	,	PUNCT
admet-2774	245	11	h	h	NOUN
admet-2774	245	12	time	time	NOUN
admet-2774	245	13	,	,	PUNCT
admet-2774	245	14	h	h	NOUN
admet-2774	245	15	time-1/2	time-1/2	ADJ
admet-2774	245	16	,	,	PUNCT
admet-2774	245	17	h-1/2	h-1/2	NOUN
admet-2774	245	18	time	time	NOUN
admet-2774	245	19	,	,	PUNCT
admet-2774	245	20	h	h	NOUN
admet-2774	245	21	y	y	NOUN
admet-2774	245	22	=	=	SYM
admet-2774	245	23	18.046x	18.046x	PROPN
admet-2774	245	24	8.2321	8.2321	NUM
admet-2774	245	25	r2	r2	NOUN
admet-2774	245	26	=	=	SYM
admet-2774	245	27	09259	09259	NUM
admet-2774	245	28	y	y	X
admet-2774	245	29	=	=	SYM
admet-2774	245	30	3.9548x	3.9548x	NUM
admet-2774	245	31	+	+	NUM
admet-2774	245	32	5.7665	5.7665	NUM
admet-2774	245	33	r2	r2	NOUN
admet-2774	245	34	=	=	PUNCT
admet-2774	245	35	0911	0911	NUM
admet-2774	245	36	y	y	X
admet-2774	245	37	=	=	SYM
admet-2774	246	1	0.0295x	0.0295x	PROPN
admet-2774	246	2	+	+	CCONJ
admet-2774	246	3	1.9967	1.9967	NUM
admet-2774	246	4	r2	r2	NOUN
admet-2774	246	5	=	=	SYM
admet-2774	246	6	0975	0975	NUM
admet-2774	247	1	y	y	X
admet-2774	247	2	=	=	SYM
admet-2774	247	3	58.395x	58.395x	NUM
admet-2774	247	4	–	–	PUNCT
admet-2774	247	5	6.6785	6.6785	NUM
admet-2774	247	6	r2	r2	NOUN
admet-2774	247	7	=	=	SYM
admet-2774	247	8	0963	0963	NUM
admet-2774	247	9	y	y	X
admet-2774	247	10	=	=	SYM
admet-2774	247	11	0.0869x	0.0869x	NOUN
admet-2774	248	1	+	+	PUNCT
admet-2774	248	2	0.0476	0.0476	NUM
admet-2774	248	3	r2	r2	NOUN
admet-2774	248	4	=	=	PUNCT
admet-2774	248	5	09587	09587	NUM
admet-2774	248	6	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	249	1	e.	e.	PROPN
admet-2774	249	2	kole	kole	PROPN
admet-2774	249	3	et	et	PROPN
admet-2774	249	4	al	al	PROPN
admet-2774	249	5	.	.	PROPN
admet-2774	249	6	admet	admet	PROPN
admet-2774	249	7	&	&	CCONJ
admet-2774	249	8	dmpk	dmpk	PROPN
admet-2774	249	9	13(4	13(4	NUM
admet-2774	249	10	)	)	PUNCT
admet-2774	249	11	(	(	PUNCT
admet-2774	249	12	2025	2025	NUM
admet-2774	249	13	)	)	PUNCT
admet-2774	249	14	2774	2774	NUM
admet-2774	249	15	14	14	NUM
admet-2774	249	16	time	time	NOUN
admet-2774	249	17	,	,	PUNCT
admet-2774	249	18	month	month	NOUN
admet-2774	249	19	time	time	NOUN
admet-2774	249	20	,	,	PUNCT
admet-2774	249	21	month	month	NOUN
admet-2774	249	22	figure	figure	NOUN
admet-2774	249	23	6	6	NUM
admet-2774	249	24	.	.	PUNCT
admet-2774	250	1	stability	stability	NOUN
admet-2774	250	2	evaluation	evaluation	NOUN
admet-2774	250	3	of	of	ADP
admet-2774	250	4	inh	inh	PROPN
admet-2774	250	5	-	-	PUNCT
admet-2774	250	6	loaded	load	VERB
admet-2774	250	7	pcl	pcl	PROPN
admet-2774	250	8	nanoparticles	nanoparticle	NOUN
admet-2774	250	9	stored	store	VERB
admet-2774	250	10	under	under	ADP
admet-2774	250	11	controlled	control	VERB
admet-2774	250	12	conditions	condition	NOUN
admet-2774	250	13	for	for	ADP
admet-2774	250	14	six	six	NUM
admet-2774	250	15	months	month	NOUN
admet-2774	250	16	:	:	PUNCT
admet-2774	250	17	(	(	PUNCT
admet-2774	250	18	a	a	X
admet-2774	250	19	)	)	PUNCT
admet-2774	250	20	changes	change	NOUN
admet-2774	250	21	in	in	ADP
admet-2774	250	22	particle	particle	NOUN
admet-2774	250	23	size	size	NOUN
admet-2774	250	24	and	and	CCONJ
admet-2774	250	25	polydispersity	polydispersity	NOUN
admet-2774	250	26	index	index	NOUN
admet-2774	250	27	and	and	CCONJ
admet-2774	250	28	(	(	PUNCT
admet-2774	250	29	b	b	X
admet-2774	250	30	)	)	PUNCT
admet-2774	250	31	zeta	zeta	NOUN
admet-2774	250	32	potential	potential	NOUN
admet-2774	250	33	(	(	PUNCT
admet-2774	250	34	mean±sd	mean±sd	PROPN
admet-2774	250	35	,	,	PUNCT
admet-2774	250	36	n=3	n=3	NOUN
admet-2774	250	37	)	)	PUNCT
admet-2774	250	38	.	.	PUNCT
admet-2774	251	1	conclusions	conclusion	NOUN
admet-2774	251	2	in	in	ADP
admet-2774	251	3	this	this	DET
admet-2774	251	4	study	study	NOUN
admet-2774	251	5	,	,	PUNCT
admet-2774	251	6	we	we	PRON
admet-2774	251	7	successfully	successfully	ADV
admet-2774	251	8	developed	develop	VERB
admet-2774	251	9	freeze	freeze	NOUN
admet-2774	251	10	-	-	PUNCT
admet-2774	251	11	dried	dry	VERB
admet-2774	251	12	isoniazid	isoniazid	NOUN
admet-2774	251	13	(	(	PUNCT
admet-2774	251	14	inh)-loaded	inh)-loaded	ADJ
admet-2774	251	15	pcl	pcl	PROPN
admet-2774	251	16	nanoparticles	nanoparticle	NOUN
admet-2774	251	17	using	use	VERB
admet-2774	251	18	a	a	DET
admet-2774	251	19	microreactor	microreactor	NOUN
admet-2774	251	20	-	-	PUNCT
admet-2774	251	21	assisted	assist	VERB
admet-2774	251	22	nanoprecipitation	nanoprecipitation	NOUN
admet-2774	251	23	method	method	NOUN
admet-2774	251	24	optimized	optimize	VERB
admet-2774	251	25	through	through	ADP
admet-2774	251	26	a	a	DET
admet-2774	251	27	bbd	bbd	NOUN
admet-2774	251	28	.	.	PUNCT
admet-2774	252	1	the	the	DET
admet-2774	252	2	optimized	optimize	VERB
admet-2774	252	3	formulation	formulation	NOUN
admet-2774	252	4	exhibited	exhibit	VERB
admet-2774	252	5	a	a	DET
admet-2774	252	6	uniform	uniform	ADJ
admet-2774	252	7	particle	particle	NOUN
admet-2774	252	8	size	size	NOUN
admet-2774	252	9	of	of	ADP
admet-2774	252	10	248.4±5.372	248.4±5.372	NUM
admet-2774	252	11	nm	nm	NOUN
admet-2774	252	12	,	,	PUNCT
admet-2774	252	13	high	high	ADJ
admet-2774	252	14	drug	drug	NOUN
admet-2774	252	15	encapsulation	encapsulation	NOUN
admet-2774	252	16	efficiency	efficiency	NOUN
admet-2774	252	17	(	(	PUNCT
admet-2774	252	18	82.26±4.36	82.26±4.36	NUM
admet-2774	252	19	%	%	NOUN
admet-2774	252	20	)	)	PUNCT
admet-2774	252	21	,	,	PUNCT
admet-2774	252	22	and	and	CCONJ
admet-2774	252	23	excellent	excellent	ADJ
admet-2774	252	24	colloidal	colloidal	NOUN
admet-2774	252	25	stability	stability	NOUN
admet-2774	252	26	under	under	ADP
admet-2774	252	27	accelerated	accelerate	VERB
admet-2774	252	28	storage	storage	NOUN
admet-2774	252	29	conditions	condition	NOUN
admet-2774	252	30	over	over	ADP
admet-2774	252	31	six	six	NUM
admet-2774	252	32	months	month	NOUN
admet-2774	252	33	.	.	PUNCT
admet-2774	253	1	comprehensive	comprehensive	ADJ
admet-2774	253	2	physicochemical	physicochemical	ADJ
admet-2774	253	3	characterization	characterization	NOUN
admet-2774	253	4	(	(	PUNCT
admet-2774	253	5	ftir	ftir	PROPN
admet-2774	253	6	,	,	PUNCT
admet-2774	253	7	dsc	dsc	PROPN
admet-2774	253	8	,	,	PUNCT
admet-2774	253	9	xrd	xrd	PROPN
admet-2774	253	10	)	)	PUNCT
admet-2774	253	11	confirmed	confirm	VERB
admet-2774	253	12	the	the	DET
admet-2774	253	13	absence	absence	NOUN
admet-2774	253	14	of	of	ADP
admet-2774	253	15	drug	drug	NOUN
admet-2774	253	16	-	-	PUNCT
admet-2774	253	17	polymer	polymer	NOUN
admet-2774	253	18	interactions	interaction	NOUN
admet-2774	253	19	,	,	PUNCT
admet-2774	253	20	while	while	SCONJ
admet-2774	253	21	sem	sem	ADJ
admet-2774	253	22	analysis	analysis	NOUN
admet-2774	253	23	revealed	reveal	VERB
admet-2774	253	24	a	a	DET
admet-2774	253	25	rod	rod	NOUN
admet-2774	253	26	-	-	PUNCT
admet-2774	253	27	like	like	ADJ
admet-2774	253	28	crystal	crystal	NOUN
admet-2774	253	29	structure	structure	NOUN
admet-2774	253	30	and	and	CCONJ
admet-2774	253	31	smooth	smooth	ADJ
admet-2774	253	32	-	-	PUNCT
admet-2774	253	33	surfaced	surface	VERB
admet-2774	253	34	nanoparticles	nanoparticle	NOUN
admet-2774	253	35	.	.	PUNCT
admet-2774	254	1	in	in	ADP
admet-2774	254	2	vitro	vitro	X
admet-2774	254	3	release	release	NOUN
admet-2774	254	4	studies	study	NOUN
admet-2774	254	5	showed	show	VERB
admet-2774	254	6	sustained	sustain	VERB
admet-2774	254	7	,	,	PUNCT
admet-2774	254	8	diffusion	diffusion	NOUN
admet-2774	254	9	-	-	PUNCT
admet-2774	254	10	controlled	control	VERB
admet-2774	254	11	drug	drug	NOUN
admet-2774	254	12	release	release	NOUN
admet-2774	254	13	,	,	PUNCT
admet-2774	254	14	with	with	ADP
admet-2774	254	15	92.45	92.45	NUM
admet-2774	254	16	%	%	NOUN
admet-2774	254	17	cumulative	cumulative	ADJ
admet-2774	254	18	release	release	NOUN
admet-2774	254	19	over	over	ADP
admet-2774	254	20	48	48	NUM
admet-2774	254	21	h.	h.	NOUN
admet-2774	254	22	this	this	DET
admet-2774	254	23	inh	inh	PROPN
admet-2774	254	24	-	-	PUNCT
admet-2774	254	25	loaded	load	VERB
admet-2774	254	26	pcl	pcl	PROPN
admet-2774	254	27	nanoformulation	nanoformulation	NOUN
admet-2774	254	28	effectively	effectively	ADV
admet-2774	254	29	addresses	address	VERB
admet-2774	254	30	key	key	ADJ
admet-2774	254	31	challenges	challenge	NOUN
admet-2774	254	32	in	in	ADP
admet-2774	254	33	tuberculosis	tuberculosis	NOUN
admet-2774	254	34	therapy	therapy	NOUN
admet-2774	254	35	by	by	ADP
admet-2774	254	36	combining	combine	VERB
admet-2774	254	37	high	high	ADJ
admet-2774	254	38	drug	drug	NOUN
admet-2774	254	39	-	-	PUNCT
admet-2774	254	40	loading	loading	NOUN
admet-2774	254	41	capacity	capacity	NOUN
admet-2774	254	42	,	,	PUNCT
admet-2774	254	43	prolonged	prolonged	ADJ
admet-2774	254	44	release	release	NOUN
admet-2774	254	45	,	,	PUNCT
admet-2774	254	46	and	and	CCONJ
admet-2774	254	47	robust	robust	ADJ
admet-2774	254	48	stability	stability	NOUN
admet-2774	254	49	,	,	PUNCT
admet-2774	254	50	offering	offer	VERB
admet-2774	254	51	a	a	DET
admet-2774	254	52	promising	promising	ADJ
admet-2774	254	53	strategy	strategy	NOUN
admet-2774	254	54	to	to	PART
admet-2774	254	55	reduce	reduce	VERB
admet-2774	254	56	dosing	dose	VERB
admet-2774	254	57	frequency	frequency	NOUN
admet-2774	254	58	and	and	CCONJ
admet-2774	254	59	enhance	enhance	VERB
admet-2774	254	60	patient	patient	ADJ
admet-2774	254	61	compliance	compliance	NOUN
admet-2774	254	62	in	in	ADP
admet-2774	254	63	pulmonary	pulmonary	ADJ
admet-2774	254	64	tb	tb	ADP
admet-2774	254	65	treatment	treatment	NOUN
admet-2774	254	66	.	.	PUNCT
admet-2774	255	1	future	future	ADJ
admet-2774	255	2	studies	study	NOUN
admet-2774	255	3	will	will	AUX
admet-2774	255	4	focus	focus	VERB
admet-2774	255	5	on	on	ADP
admet-2774	255	6	in	in	ADP
admet-2774	255	7	vivo	vivo	ADJ
admet-2774	255	8	pharmacokinetic	pharmacokinetic	ADJ
admet-2774	255	9	and	and	CCONJ
admet-2774	255	10	biodistribution	biodistribution	NOUN
admet-2774	255	11	assessments	assessment	NOUN
admet-2774	255	12	to	to	PART
admet-2774	255	13	further	far	ADV
admet-2774	255	14	evaluate	evaluate	VERB
admet-2774	255	15	the	the	DET
admet-2774	255	16	formulation	formulation	NOUN
admet-2774	255	17	's	's	PART
admet-2774	255	18	therapeutic	therapeutic	ADJ
admet-2774	255	19	potential	potential	NOUN
admet-2774	255	20	and	and	CCONJ
admet-2774	255	21	lung	lung	NOUN
admet-2774	255	22	-	-	PUNCT
admet-2774	255	23	targeting	target	VERB
admet-2774	255	24	efficiency	efficiency	NOUN
admet-2774	255	25	.	.	PUNCT
admet-2774	256	1	funding	funding	NOUN
admet-2774	256	2	:	:	PUNCT
admet-2774	256	3	this	this	DET
admet-2774	256	4	study	study	NOUN
admet-2774	256	5	was	be	AUX
admet-2774	256	6	financially	financially	ADV
admet-2774	256	7	supported	support	VERB
admet-2774	256	8	by	by	ADP
admet-2774	256	9	the	the	DET
admet-2774	256	10	science	science	NOUN
admet-2774	256	11	and	and	CCONJ
admet-2774	256	12	engineering	engineering	NOUN
admet-2774	256	13	research	research	NOUN
admet-2774	256	14	board	board	NOUN
admet-2774	256	15	(	(	PUNCT
admet-2774	256	16	serb	serb	NOUN
admet-2774	256	17	)	)	PUNCT
admet-2774	256	18	,	,	PUNCT
admet-2774	256	19	new	new	PROPN
admet-2774	256	20	delhi	delhi	PROPN
admet-2774	256	21	,	,	PUNCT
admet-2774	256	22	in	in	ADP
admet-2774	256	23	terms	term	NOUN
admet-2774	256	24	of	of	ADP
admet-2774	256	25	empowerment	empowerment	NOUN
admet-2774	256	26	and	and	CCONJ
admet-2774	256	27	equity	equity	NOUN
admet-2774	256	28	opportunities	opportunity	NOUN
admet-2774	256	29	for	for	ADP
admet-2774	256	30	excellence	excellence	NOUN
admet-2774	256	31	in	in	ADP
admet-2774	256	32	science	science	NOUN
admet-2774	256	33	(	(	PUNCT
admet-2774	256	34	eeq/2023/000060	eeq/2023/000060	NOUN
admet-2774	256	35	)	)	PUNCT
admet-2774	256	36	.	.	PUNCT
admet-2774	257	1	acknowledgements	acknowledgement	NOUN
admet-2774	257	2	:	:	PUNCT
admet-2774	257	3	one	one	NUM
admet-2774	257	4	of	of	ADP
admet-2774	257	5	the	the	DET
admet-2774	257	6	authors	author	NOUN
admet-2774	257	7	is	be	AUX
admet-2774	257	8	grateful	grateful	ADJ
admet-2774	257	9	to	to	PART
admet-2774	257	10	barti	barti	VERB
admet-2774	257	11	,	,	PUNCT
admet-2774	257	12	pune	pune	NOUN
admet-2774	257	13	,	,	PUNCT
admet-2774	257	14	for	for	ADP
admet-2774	257	15	providing	provide	VERB
admet-2774	257	16	dr	dr	PROPN
admet-2774	257	17	.	.	PROPN
admet-2774	257	18	babasaheb	babasaheb	PROPN
admet-2774	257	19	ambedkar	ambedkar	PROPN
admet-2774	257	20	national	national	PROPN
admet-2774	257	21	research	research	PROPN
admet-2774	257	22	fellowship	fellowship	NOUN
admet-2774	257	23	(	(	PUNCT
admet-2774	257	24	banrf	banrf	NOUN
admet-2774	257	25	)	)	PUNCT
admet-2774	257	26	.	.	PUNCT
admet-2774	258	1	the	the	DET
admet-2774	258	2	authors	author	NOUN
admet-2774	258	3	gratefully	gratefully	ADV
admet-2774	258	4	acknowledge	acknowledge	VERB
admet-2774	258	5	lupin	lupin	PROPN
admet-2774	258	6	ltd	ltd	PROPN
admet-2774	258	7	.	.	PROPN
admet-2774	259	1	(	(	PUNCT
admet-2774	259	2	cha	cha	X
admet-2774	259	3	.	.	PUNCT
admet-2774	259	4	sambhajinagar	sambhajinagar	NOUN
admet-2774	259	5	,	,	PUNCT
admet-2774	259	6	india	india	PROPN
admet-2774	259	7	)	)	PUNCT
admet-2774	259	8	for	for	ADP
admet-2774	259	9	providing	provide	VERB
admet-2774	259	10	the	the	DET
admet-2774	259	11	gift	gift	NOUN
admet-2774	259	12	sample	sample	NOUN
admet-2774	259	13	of	of	ADP
admet-2774	259	14	isoniazid	isoniazid	NOUN
admet-2774	259	15	.	.	PUNCT
admet-2774	260	1	conflict	conflict	NOUN
admet-2774	260	2	of	of	ADP
admet-2774	260	3	interest	interest	NOUN
admet-2774	260	4	:	:	PUNCT
admet-2774	260	5	the	the	DET
admet-2774	260	6	authors	author	NOUN
admet-2774	260	7	state	state	VERB
admet-2774	260	8	that	that	SCONJ
admet-2774	260	9	they	they	PRON
admet-2774	260	10	have	have	VERB
admet-2774	260	11	no	no	DET
admet-2774	260	12	competing	compete	VERB
admet-2774	260	13	financial	financial	ADJ
admet-2774	260	14	interests	interest	NOUN
admet-2774	260	15	or	or	CCONJ
admet-2774	260	16	personal	personal	ADJ
admet-2774	260	17	relationships	relationship	NOUN
admet-2774	260	18	that	that	PRON
admet-2774	260	19	could	could	AUX
admet-2774	260	20	have	have	AUX
admet-2774	260	21	influenced	influence	VERB
admet-2774	260	22	the	the	DET
admet-2774	260	23	work	work	NOUN
admet-2774	260	24	presented	present	VERB
admet-2774	260	25	in	in	ADP
admet-2774	260	26	this	this	DET
admet-2774	260	27	paper	paper	NOUN
admet-2774	260	28	.	.	PUNCT
admet-2774	261	1	author	author	NOUN
admet-2774	261	2	contributions	contribution	NOUN
admet-2774	261	3	:	:	PUNCT
admet-2774	261	4	eknath	eknath	PROPN
admet-2774	261	5	kole	kole	PROPN
admet-2774	261	6	:	:	PUNCT
admet-2774	261	7	conceptualization	conceptualization	NOUN
admet-2774	261	8	,	,	PUNCT
admet-2774	261	9	experimentation	experimentation	NOUN
admet-2774	261	10	,	,	PUNCT
admet-2774	261	11	data	data	NOUN
admet-2774	261	12	curation	curation	NOUN
admet-2774	261	13	,	,	PUNCT
admet-2774	261	14	writing	write	VERB
admet-2774	261	15	original	original	ADJ
admet-2774	261	16	draft	draft	NOUN
admet-2774	261	17	,	,	PUNCT
admet-2774	261	18	writing	write	VERB
admet-2774	261	19	review	review	NOUN
admet-2774	261	20	&	&	CCONJ
admet-2774	261	21	editing	editing	PROPN
admet-2774	261	22	,	,	PUNCT
admet-2774	261	23	yuvraj	yuvraj	PROPN
admet-2774	261	24	pawara	pawara	NOUN
admet-2774	261	25	:	:	PUNCT
admet-2774	262	1	experimentation	experimentation	NOUN
admet-2774	262	2	,	,	PUNCT
admet-2774	262	3	atul	atul	PROPN
admet-2774	262	4	chaudhari	chaudhari	PROPN
admet-2774	262	5	:	:	PUNCT
admet-2774	262	6	experimentation	experimentation	NOUN
admet-2774	262	7	,	,	PUNCT
admet-2774	262	8	anniruddha	anniruddha	PROPN
admet-2774	262	9	chatterjee	chatterjee	PROPN
admet-2774	262	10	:	:	PUNCT
admet-2774	262	11	writing	write	VERB
admet-2774	262	12	review	review	NOUN
admet-2774	262	13	&	&	CCONJ
admet-2774	262	14	editing	editing	PROPN
admet-2774	262	15	,	,	PUNCT
admet-2774	262	16	jitendra	jitendra	PROPN
admet-2774	262	17	naik	naik	PROPN
admet-2774	262	18	:	:	PUNCT
admet-2774	262	19	writing	write	VERB
admet-2774	262	20	review	review	NOUN
admet-2774	262	21	&	&	CCONJ
admet-2774	262	22	editing	editing	PROPN
admet-2774	262	23	,	,	PUNCT
admet-2774	262	24	project	project	NOUN
admet-2774	262	25	administration	administration	NOUN
admet-2774	262	26	,	,	PUNCT
admet-2774	262	27	funding	funding	NOUN
admet-2774	262	28	acquisition	acquisition	NOUN
admet-2774	262	29	,	,	PUNCT
admet-2774	262	30	supervision	supervision	NOUN
admet-2774	262	31	.	.	PUNCT
admet-2774	263	1	data	datum	NOUN
admet-2774	263	2	availability	availability	NOUN
admet-2774	263	3	:	:	PUNCT
admet-2774	263	4	the	the	DET
admet-2774	263	5	datasets	dataset	NOUN
admet-2774	263	6	generated	generate	VERB
admet-2774	263	7	during	during	ADP
admet-2774	263	8	and/or	and/or	CCONJ
admet-2774	263	9	analysed	analyse	VERB
admet-2774	263	10	during	during	ADP
admet-2774	263	11	the	the	DET
admet-2774	263	12	current	current	ADJ
admet-2774	263	13	study	study	NOUN
admet-2774	263	14	are	be	AUX
admet-2774	263	15	not	not	PART
admet-2774	263	16	publicly	publicly	ADV
admet-2774	263	17	available	available	ADJ
admet-2774	263	18	for	for	ADP
admet-2774	263	19	technical	technical	ADJ
admet-2774	263	20	reasons	reason	NOUN
admet-2774	263	21	but	but	CCONJ
admet-2774	263	22	are	be	AUX
admet-2774	263	23	available	available	ADJ
admet-2774	263	24	from	from	ADP
admet-2774	263	25	the	the	DET
admet-2774	263	26	corresponding	corresponding	ADJ
admet-2774	263	27	author	author	NOUN
admet-2774	263	28	on	on	ADP
admet-2774	263	29	reasonable	reasonable	ADJ
admet-2774	263	30	request	request	NOUN
admet-2774	263	31	.	.	PUNCT
admet-2774	264	1	references	reference	NOUN
admet-2774	264	2	[	[	X
admet-2774	264	3	1	1	NUM
admet-2774	264	4	]	]	X
admet-2774	264	5	a.z	a.z	PROPN
admet-2774	264	6	.	.	PROPN
admet-2774	264	7	bahlool	bahlool	PROPN
admet-2774	264	8	,	,	PUNCT
admet-2774	264	9	b.	b.	PROPN
admet-2774	264	10	cavanagh	cavanagh	PROPN
admet-2774	264	11	,	,	PUNCT
admet-2774	264	12	a.o	a.o	PROPN
admet-2774	264	13	.	.	PROPN
admet-2774	264	14	sullivan	sullivan	PROPN
admet-2774	264	15	,	,	PUNCT
admet-2774	264	16	r.	r.	PROPN
admet-2774	264	17	macloughlin	macloughlin	PROPN
admet-2774	264	18	,	,	PUNCT
admet-2774	264	19	j.	j.	PROPN
admet-2774	264	20	keane	keane	PROPN
admet-2774	264	21	,	,	PUNCT
admet-2774	264	22	m.p.o	m.p.o	PROPN
admet-2774	264	23	.	.	PUNCT
admet-2774	265	1	sullivan	sullivan	PROPN
admet-2774	265	2	,	,	PUNCT
admet-2774	265	3	s.a	s.a	PROPN
admet-2774	265	4	.	.	PROPN
admet-2774	265	5	cryan	cryan	PROPN
admet-2774	265	6	.	.	PUNCT
admet-2774	266	1	microfluidics	microfluidic	NOUN
admet-2774	266	2	produced	produce	VERB
admet-2774	266	3	atra	atra	NOUN
admet-2774	266	4	-	-	PUNCT
admet-2774	266	5	loaded	load	VERB
admet-2774	266	6	plga	plga	NOUN
admet-2774	266	7	nps	nps	PROPN
admet-2774	266	8	reduced	reduce	VERB
admet-2774	266	9	tuberculosis	tuberculosis	NOUN
admet-2774	266	10	burden	burden	NOUN
admet-2774	266	11	in	in	ADP
admet-2774	266	12	alveolar	alveolar	ADJ
admet-2774	266	13	epithelial	epithelial	ADJ
admet-2774	266	14	cells	cell	NOUN
admet-2774	266	15	and	and	CCONJ
admet-2774	266	16	enabled	enable	VERB
admet-2774	266	17	high	high	ADV
admet-2774	266	18	delivered	deliver	VERB
admet-2774	266	19	dose	dose	NOUN
admet-2774	266	20	under	under	ADP
admet-2774	266	21	simulated	simulate	VERB
admet-2774	266	22	human	human	ADJ
admet-2774	266	23	breathing	breathing	NOUN
admet-2774	266	24	pattern	pattern	NOUN
admet-2774	266	25	in	in	ADP
admet-2774	266	26	3d	3d	PROPN
admet-2774	266	27	printed	print	VERB
admet-2774	266	28	head	head	NOUN
admet-2774	266	29	models	model	NOUN
admet-2774	266	30	.	.	PUNCT
admet-2774	267	1	european	european	ADJ
admet-2774	267	2	journal	journal	PROPN
admet-2774	267	3	of	of	ADP
admet-2774	267	4	pharmaceutical	pharmaceutical	PROPN
admet-2774	267	5	sciences	science	NOUN
admet-2774	267	6	196	196	NUM
admet-2774	267	7	(	(	PUNCT
admet-2774	267	8	2024	2024	NUM
admet-2774	267	9	)	)	PUNCT
admet-2774	267	10	106734	106734	NUM
admet-2774	267	11	.	.	PUNCT
admet-2774	268	1	https://doi.org/10.1016/j.ejps.2024.106734	https://doi.org/10.1016/j.ejps.2024.106734	ADV
admet-2774	268	2	p	p	PROPN
admet-2774	268	3	ar	ar	NOUN
admet-2774	268	4	ti	ti	NOUN
admet-2774	268	5	cl	cl	NOUN
admet-2774	268	6	e	e	NOUN
admet-2774	268	7	si	si	PROPN
admet-2774	268	8	ze	ze	PROPN
admet-2774	268	9	,	,	PUNCT
admet-2774	268	10	n	n	CCONJ
admet-2774	268	11	m	m	VERB
admet-2774	268	12	ze	ze	NOUN
admet-2774	268	13	ta	ta	ADP
admet-2774	268	14	p	p	X
admet-2774	268	15	o	o	X
admet-2774	268	16	te	te	ADP
admet-2774	268	17	n	n	CCONJ
admet-2774	268	18	ti	ti	PROPN
admet-2774	268	19	al	al	PROPN
admet-2774	268	20	,	,	PUNCT
admet-2774	268	21	m	m	VERB
admet-2774	268	22	v	v	ADP
admet-2774	268	23	https://doi.org/10.1016/j.ejps.2024.106734	https://doi.org/10.1016/j.ejps.2024.106734	PROPN
admet-2774	268	24	admet	admet	PROPN
admet-2774	268	25	&	&	CCONJ
admet-2774	268	26	dmpk	dmpk	PROPN
admet-2774	268	27	13(4	13(4	NUM
admet-2774	268	28	)	)	PUNCT
admet-2774	268	29	(	(	PUNCT
admet-2774	268	30	2025	2025	NUM
admet-2774	268	31	)	)	PUNCT
admet-2774	268	32	2774	2774	NUM
admet-2774	268	33	freeze	freeze	NOUN
admet-2774	268	34	-	-	PUNCT
admet-2774	268	35	dried	dry	VERB
admet-2774	268	36	isoniazid	isoniazid	NOUN
admet-2774	268	37	-	-	PUNCT
admet-2774	268	38	loaded	load	VERB
admet-2774	268	39	poly	poly	ADJ
admet-2774	268	40	-	-	PUNCT
admet-2774	268	41	ε	ε	NOUN
admet-2774	268	42	-	-	PUNCT
admet-2774	268	43	caprolactone	caprolactone	ADJ
admet-2774	268	44	nanoparticles	nanoparticle	NOUN
admet-2774	268	45	doi	doi	NOUN
admet-2774	268	46	:	:	PUNCT
admet-2774	268	47	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	268	48	15	15	NUM
admet-2774	269	1	[	[	SYM
admet-2774	269	2	2	2	NUM
admet-2774	269	3	]	]	X
admet-2774	269	4	k.m.s.r	k.m.s.r	PROPN
admet-2774	269	5	.	.	PROPN
admet-2774	269	6	sefat	sefat	PROPN
admet-2774	269	7	,	,	PUNCT
admet-2774	269	8	m.	m.	NOUN
admet-2774	269	9	kumar	kumar	PROPN
admet-2774	269	10	,	,	PUNCT
admet-2774	269	11	s.	s.	PROPN
admet-2774	269	12	kehl	kehl	PROPN
admet-2774	269	13	,	,	PUNCT
admet-2774	269	14	r.	r.	PROPN
admet-2774	269	15	kulkarni	kulkarni	PROPN
admet-2774	269	16	,	,	PUNCT
admet-2774	269	17	a.	a.	PROPN
admet-2774	269	18	leekha	leekha	PROPN
admet-2774	269	19	,	,	PUNCT
admet-2774	269	20	m.m	m.m	PROPN
admet-2774	269	21	.	.	PROPN
admet-2774	269	22	paniagua	paniagua	PROPN
admet-2774	269	23	,	,	PUNCT
admet-2774	269	24	d.f	d.f	PROPN
admet-2774	269	25	.	.	PROPN
admet-2774	269	26	ackart	ackart	PROPN
admet-2774	269	27	,	,	PUNCT
admet-2774	269	28	n.	n.	PROPN
admet-2774	269	29	jones	jones	PROPN
admet-2774	269	30	,	,	PUNCT
admet-2774	269	31	c.	c.	PROPN
admet-2774	269	32	spencer	spencer	PROPN
admet-2774	269	33	,	,	PUNCT
admet-2774	269	34	b.k	b.k	PROPN
admet-2774	269	35	.	.	NOUN
admet-2774	269	36	podell	podell	PROPN
admet-2774	269	37	,	,	PUNCT
admet-2774	269	38	h.	h.	PROPN
admet-2774	269	39	ouellet	ouellet	PROPN
admet-2774	269	40	,	,	PUNCT
admet-2774	269	41	n.	n.	PROPN
admet-2774	269	42	varadarajan	varadarajan	PROPN
admet-2774	269	43	.	.	PUNCT
admet-2774	270	1	an	an	DET
admet-2774	270	2	intranasal	intranasal	ADJ
admet-2774	270	3	nanoparticle	nanoparticle	NOUN
admet-2774	270	4	vaccine	vaccine	NOUN
admet-2774	270	5	elicits	elicit	VERB
admet-2774	270	6	protective	protective	ADJ
admet-2774	270	7	immunity	immunity	NOUN
admet-2774	270	8	against	against	ADP
admet-2774	270	9	mycobacterium	mycobacterium	NOUN
admet-2774	270	10	tuberculosis	tuberculosis	NOUN
admet-2774	270	11	.	.	PUNCT
admet-2774	271	1	vaccine	vaccine	NOUN
admet-2774	271	2	42(22	42(22	PROPN
admet-2774	271	3	)	)	PUNCT
admet-2774	271	4	(	(	PUNCT
admet-2774	271	5	2024	2024	NUM
admet-2774	271	6	)	)	PUNCT
admet-2774	271	7	125909	125909	NUM
admet-2774	271	8	.	.	PUNCT
admet-2774	272	1	https://doi.org/10.1016/j.vaccine.2024.04.055	https://doi.org/10.1016/j.vaccine.2024.04.055	PROPN
admet-2774	273	1	[	[	X
admet-2774	273	2	3	3	NUM
admet-2774	273	3	]	]	X
admet-2774	273	4	global	global	ADJ
admet-2774	273	5	tuberculosis	tuberculosis	NOUN
admet-2774	273	6	report	report	NOUN
admet-2774	273	7	2024	2024	NUM
admet-2774	273	8	.	.	PUNCT
admet-2774	274	1	geneva	geneva	NOUN
admet-2774	274	2	:	:	PUNCT
admet-2774	274	3	world	world	PROPN
admet-2774	274	4	health	health	PROPN
admet-2774	274	5	organization	organization	NOUN
admet-2774	274	6	,	,	PUNCT
admet-2774	274	7	2024	2024	NUM
admet-2774	274	8	.	.	PUNCT
admet-2774	275	1	isbn	isbn	ADJ
admet-2774	275	2	978	978	NUM
admet-2774	275	3	-	-	SYM
admet-2774	275	4	92	92	NUM
admet-2774	275	5	-	-	PUNCT
admet-2774	275	6	4	4	NUM
admet-2774	275	7	-	-	PUNCT
admet-2774	275	8	010153	010153	NUM
admet-2774	275	9	-	-	SYM
admet-2774	275	10	1	1	NUM
admet-2774	275	11	[	[	X
admet-2774	275	12	4	4	NUM
admet-2774	275	13	]	]	X
admet-2774	275	14	l.	l.	PROPN
admet-2774	275	15	luies	luies	PROPN
admet-2774	275	16	,	,	PUNCT
admet-2774	275	17	i.	i.	PROPN
admet-2774	275	18	du	du	PROPN
admet-2774	275	19	preez	preez	PROPN
admet-2774	275	20	.	.	PUNCT
admet-2774	276	1	the	the	DET
admet-2774	276	2	echo	echo	NOUN
admet-2774	276	3	of	of	ADP
admet-2774	276	4	pulmonary	pulmonary	ADJ
admet-2774	276	5	tuberculosis	tuberculosis	NOUN
admet-2774	276	6	:	:	PUNCT
admet-2774	276	7	mechanisms	mechanism	NOUN
admet-2774	276	8	of	of	ADP
admet-2774	276	9	clinical	clinical	ADJ
admet-2774	276	10	symptoms	symptom	NOUN
admet-2774	276	11	and	and	CCONJ
admet-2774	276	12	other	other	ADJ
admet-2774	276	13	disease	disease	NOUN
admet-2774	276	14	-	-	PUNCT
admet-2774	276	15	induced	induce	VERB
admet-2774	276	16	systemic	systemic	ADJ
admet-2774	276	17	complications	complication	NOUN
admet-2774	276	18	.	.	PUNCT
admet-2774	277	1	clinical	clinical	ADJ
admet-2774	277	2	microbiology	microbiology	NOUN
admet-2774	277	3	reviews	review	NOUN
admet-2774	277	4	33(4	33(4	NUM
admet-2774	277	5	)	)	PUNCT
admet-2774	277	6	(	(	PUNCT
admet-2774	277	7	2020	2020	NUM
admet-2774	277	8	)	)	PUNCT
admet-2774	277	9	10	10	NUM
admet-2774	277	10	-	-	SYM
admet-2774	277	11	1128	1128	NUM
admet-2774	277	12	.	.	PUNCT
admet-2774	278	1	https://doi.org/10.1128/cmr.00036-20	https://doi.org/10.1128/cmr.00036-20	X
admet-2774	279	1	[	[	X
admet-2774	279	2	5	5	NUM
admet-2774	279	3	]	]	X
admet-2774	279	4	c.b.e	c.b.e	NOUN
admet-2774	279	5	.	.	PUNCT
admet-2774	279	6	chee	chee	NOUN
admet-2774	279	7	,	,	PUNCT
admet-2774	279	8	r.	r.	PROPN
admet-2774	279	9	reves	reves	PROPN
admet-2774	279	10	,	,	PUNCT
admet-2774	279	11	y.	y.	PROPN
admet-2774	279	12	zhang	zhang	PROPN
admet-2774	279	13	,	,	PUNCT
admet-2774	279	14	r.	r.	PROPN
admet-2774	279	15	belknap	belknap	PROPN
admet-2774	279	16	.	.	PUNCT
admet-2774	280	1	latent	latent	PROPN
admet-2774	280	2	tuberculosis	tuberculosis	NOUN
admet-2774	280	3	infection	infection	NOUN
admet-2774	280	4	:	:	PUNCT
admet-2774	280	5	opportunities	opportunity	NOUN
admet-2774	280	6	and	and	CCONJ
admet-2774	280	7	challenges	challenge	NOUN
admet-2774	280	8	.	.	PUNCT
admet-2774	281	1	respirology	respirology	NOUN
admet-2774	281	2	23	23	NUM
admet-2774	281	3	(	(	PUNCT
admet-2774	281	4	2018	2018	NUM
admet-2774	281	5	)	)	PUNCT
admet-2774	281	6	893	893	NUM
admet-2774	281	7	-	-	SYM
admet-2774	281	8	900	900	NUM
admet-2774	281	9	.	.	PUNCT
admet-2774	282	1	https://doi.org/10.1111/resp.13346	https://doi.org/10.1111/resp.13346	VERB
admet-2774	282	2	[	[	X
admet-2774	282	3	6	6	NUM
admet-2774	282	4	]	]	PUNCT
admet-2774	282	5	a.	a.	NOUN
admet-2774	282	6	mobed	mob	VERB
admet-2774	282	7	,	,	PUNCT
admet-2774	282	8	v.	v.	ADP
admet-2774	282	9	alivirdiloo	alivirdiloo	PROPN
admet-2774	282	10	,	,	PUNCT
admet-2774	282	11	s.	s.	PROPN
admet-2774	282	12	gholami	gholami	PROPN
admet-2774	282	13	,	,	PUNCT
admet-2774	282	14	a.	a.	NOUN
admet-2774	282	15	moshari	moshari	PROPN
admet-2774	282	16	,	,	PUNCT
admet-2774	282	17	a.	a.	NOUN
admet-2774	282	18	mousavizade	mousavizade	PROPN
admet-2774	282	19	,	,	PUNCT
admet-2774	282	20	r.	r.	PROPN
admet-2774	282	21	naderian	naderian	PROPN
admet-2774	282	22	,	,	PUNCT
admet-2774	282	23	f.	f.	PROPN
admet-2774	282	24	ghazi	ghazi	PROPN
admet-2774	282	25	.	.	PUNCT
admet-2774	283	1	nanomedicine	nanomedicine	PROPN
admet-2774	283	2	for	for	ADP
admet-2774	283	3	treatment	treatment	NOUN
admet-2774	283	4	of	of	ADP
admet-2774	283	5	tuberculosis	tuberculosis	NOUN
admet-2774	283	6	,	,	PUNCT
admet-2774	283	7	promising	promise	VERB
admet-2774	283	8	approaches	approach	NOUN
admet-2774	283	9	against	against	ADP
admet-2774	283	10	antimicrobial	antimicrobial	ADJ
admet-2774	283	11	resistance	resistance	NOUN
admet-2774	283	12	.	.	PUNCT
admet-2774	284	1	current	current	ADJ
admet-2774	284	2	microbiology	microbiology	NOUN
admet-2774	284	3	81	81	NUM
admet-2774	284	4	(	(	PUNCT
admet-2774	284	5	2024	2024	NUM
admet-2774	284	6	)	)	PUNCT
admet-2774	284	7	326	326	NUM
admet-2774	284	8	.	.	PUNCT
admet-2774	285	1	https://doi.org/10.1007/s00284-024-03853-z	https://doi.org/10.1007/s00284-024-03853-z	PROPN
admet-2774	286	1	[	[	X
admet-2774	286	2	7	7	NUM
admet-2774	286	3	]	]	X
admet-2774	286	4	s.m	s.m	PROPN
admet-2774	286	5	.	.	PROPN
admet-2774	286	6	patil	patil	PROPN
admet-2774	286	7	,	,	PUNCT
admet-2774	286	8	a.m.	a.m.	PROPN
admet-2774	286	9	diorio	diorio	PROPN
admet-2774	286	10	,	,	PUNCT
admet-2774	286	11	p.	p.	PROPN
admet-2774	286	12	kommarajula	kommarajula	PROPN
admet-2774	286	13	,	,	PUNCT
admet-2774	286	14	n.k	n.k	PROPN
admet-2774	286	15	.	.	PROPN
admet-2774	286	16	kunda	kunda	PROPN
admet-2774	286	17	.	.	PUNCT
admet-2774	287	1	a	a	DET
admet-2774	287	2	quality	quality	NOUN
admet-2774	287	3	-	-	PUNCT
admet-2774	287	4	by	by	ADP
admet-2774	287	5	-	-	PUNCT
admet-2774	287	6	design	design	NOUN
admet-2774	287	7	strategic	strategic	ADJ
admet-2774	287	8	approach	approach	NOUN
admet-2774	287	9	for	for	ADP
admet-2774	287	10	the	the	DET
admet-2774	287	11	development	development	NOUN
admet-2774	287	12	of	of	ADP
admet-2774	287	13	bedaquiline	bedaquiline	NOUN
admet-2774	287	14	-	-	PUNCT
admet-2774	287	15	pretomanid	pretomanid	ADJ
admet-2774	287	16	nanoparticles	nanoparticle	NOUN
admet-2774	287	17	as	as	ADP
admet-2774	287	18	inhalable	inhalable	ADJ
admet-2774	287	19	dry	dry	ADJ
admet-2774	287	20	powders	powder	NOUN
admet-2774	287	21	for	for	ADP
admet-2774	287	22	tb	tb	ADP
admet-2774	287	23	treatment	treatment	NOUN
admet-2774	287	24	.	.	PUNCT
admet-2774	288	1	international	international	ADJ
admet-2774	288	2	journal	journal	PROPN
admet-2774	288	3	of	of	ADP
admet-2774	288	4	pharmaceutics	pharmaceutic	NOUN
admet-2774	288	5	653	653	NUM
admet-2774	288	6	(	(	PUNCT
admet-2774	288	7	2024	2024	NUM
admet-2774	288	8	)	)	PUNCT
admet-2774	288	9	123920	123920	NUM
admet-2774	288	10	.	.	PUNCT
admet-2774	289	1	https://doi.org/10.1016/j.ijpharm.2024.123920	https://doi.org/10.1016/j.ijpharm.2024.123920	ADV
admet-2774	289	2	[	[	X
admet-2774	289	3	8	8	NUM
admet-2774	289	4	]	]	X
admet-2774	289	5	g.	g.	PROPN
admet-2774	289	6	fekadu	fekadu	PROPN
admet-2774	289	7	,	,	PUNCT
admet-2774	289	8	f.	f.	PROPN
admet-2774	289	9	bekele	bekele	PROPN
admet-2774	289	10	,	,	PUNCT
admet-2774	289	11	k.	k.	PROPN
admet-2774	289	12	bekele	bekele	PROPN
admet-2774	289	13	,	,	PUNCT
admet-2774	289	14	t.	t.	PROPN
admet-2774	289	15	girma	girma	PROPN
admet-2774	289	16	,	,	PUNCT
admet-2774	289	17	g.	g.	PROPN
admet-2774	289	18	mosisa	mosisa	NOUN
admet-2774	289	19	,	,	PUNCT
admet-2774	289	20	m.	m.	NOUN
admet-2774	289	21	gebre	gebre	PROPN
admet-2774	289	22	,	,	PUNCT
admet-2774	289	23	t.	t.	PROPN
admet-2774	289	24	alemu	alemu	PROPN
admet-2774	289	25	,	,	PUNCT
admet-2774	289	26	t.	t.	PROPN
admet-2774	289	27	tekle	tekle	NOUN
admet-2774	289	28	,	,	PUNCT
admet-2774	289	29	b.	b.	PROPN
admet-2774	289	30	gamachu	gamachu	PROPN
admet-2774	289	31	,	,	PUNCT
admet-2774	289	32	a.	a.	PROPN
admet-2774	289	33	diriba	diriba	PROPN
admet-2774	289	34	.	.	PUNCT
admet-2774	290	1	adherence	adherence	NOUN
admet-2774	290	2	to	to	ADP
admet-2774	290	3	anti	anti	ADJ
admet-2774	290	4	-	-	ADJ
admet-2774	290	5	tuberculosis	tuberculosis	ADJ
admet-2774	290	6	treatment	treatment	NOUN
admet-2774	290	7	among	among	ADP
admet-2774	290	8	pediatric	pediatric	ADJ
admet-2774	290	9	patients	patient	NOUN
admet-2774	290	10	at	at	ADP
admet-2774	290	11	nekemte	nekemte	PROPN
admet-2774	290	12	specialized	specialized	ADJ
admet-2774	290	13	hospital	hospital	NOUN
admet-2774	290	14	,	,	PUNCT
admet-2774	290	15	western	western	ADJ
admet-2774	290	16	ethiopia	ethiopia	PROPN
admet-2774	290	17	.	.	PUNCT
admet-2774	291	1	patient	patient	ADJ
admet-2774	291	2	preference	preference	NOUN
admet-2774	291	3	and	and	CCONJ
admet-2774	291	4	adherence	adherence	NOUN
admet-2774	291	5	14	14	NUM
admet-2774	291	6	(	(	PUNCT
admet-2774	291	7	2020	2020	NUM
admet-2774	291	8	)	)	PUNCT
admet-2774	291	9	1259	1259	NUM
admet-2774	291	10	-	-	SYM
admet-2774	291	11	1265	1265	NUM
admet-2774	291	12	.	.	PUNCT
admet-2774	292	1	https://doi.org/10.2147/ppa.s258292	https://doi.org/10.2147/ppa.s258292	X
admet-2774	293	1	[	[	X
admet-2774	293	2	9	9	NUM
admet-2774	293	3	]	]	PUNCT
admet-2774	293	4	s.	s.	PROPN
admet-2774	293	5	bea	bea	PROPN
admet-2774	293	6	,	,	PUNCT
admet-2774	293	7	h.	h.	PROPN
admet-2774	293	8	lee	lee	PROPN
admet-2774	293	9	,	,	PUNCT
admet-2774	293	10	j.h	j.h	PROPN
admet-2774	293	11	.	.	PROPN
admet-2774	293	12	kim	kim	PROPN
admet-2774	293	13	,	,	PUNCT
admet-2774	293	14	s.h	s.h	PROPN
admet-2774	293	15	.	.	PROPN
admet-2774	293	16	jang	jang	PROPN
admet-2774	293	17	,	,	PUNCT
admet-2774	293	18	h.	h.	PROPN
admet-2774	293	19	son	son	PROPN
admet-2774	293	20	,	,	PUNCT
admet-2774	293	21	j.-w	j.-w	PROPN
admet-2774	293	22	.	.	PUNCT
admet-2774	294	1	kwon	kwon	PROPN
admet-2774	294	2	,	,	PUNCT
admet-2774	294	3	j.-y	j.-y	PROPN
admet-2774	294	4	.	.	PUNCT
admet-2774	295	1	shin	shin	PROPN
admet-2774	295	2	.	.	PUNCT
admet-2774	296	1	adherence	adherence	NOUN
admet-2774	296	2	and	and	CCONJ
admet-2774	296	3	associated	associated	ADJ
admet-2774	296	4	factors	factor	NOUN
admet-2774	296	5	of	of	ADP
admet-2774	296	6	treatment	treatment	NOUN
admet-2774	296	7	regimen	regiman	NOUN
admet-2774	296	8	in	in	ADP
admet-2774	296	9	drug	drug	NOUN
admet-2774	296	10	-	-	PUNCT
admet-2774	296	11	susceptible	susceptible	ADJ
admet-2774	296	12	tuberculosis	tuberculosis	NOUN
admet-2774	296	13	patients	patient	NOUN
admet-2774	296	14	.	.	PUNCT
admet-2774	297	1	frontiers	frontier	NOUN
admet-2774	297	2	in	in	ADP
admet-2774	297	3	pharmacology	pharmacology	NOUN
admet-2774	297	4	12	12	NUM
admet-2774	297	5	(	(	PUNCT
admet-2774	297	6	2021	2021	NUM
admet-2774	297	7	)	)	PUNCT
admet-2774	297	8	625078	625078	NUM
admet-2774	297	9	.	.	PUNCT
admet-2774	298	1	https://doi.org/10.3389/fphar.2021.625078	https://doi.org/10.3389/fphar.2021.625078	PROPN
admet-2774	299	1	[	[	X
admet-2774	299	2	10	10	NUM
admet-2774	299	3	]	]	X
admet-2774	299	4	u.a	u.a	PROPN
admet-2774	299	5	.	.	PROPN
admet-2774	299	6	boelsterli	boelsterli	PROPN
admet-2774	299	7	,	,	PUNCT
admet-2774	299	8	k.k	k.k	PROPN
admet-2774	299	9	.	.	PROPN
admet-2774	299	10	lee	lee	PROPN
admet-2774	299	11	.	.	PROPN
admet-2774	299	12	mechanisms	mechanism	NOUN
admet-2774	299	13	of	of	ADP
admet-2774	299	14	isoniazid	isoniazid	NOUN
admet-2774	299	15	-	-	PUNCT
admet-2774	299	16	induced	induce	VERB
admet-2774	299	17	idiosyncratic	idiosyncratic	ADJ
admet-2774	299	18	liver	liver	NOUN
admet-2774	299	19	injury	injury	NOUN
admet-2774	299	20	:	:	PUNCT
admet-2774	299	21	emerging	emerge	VERB
admet-2774	299	22	role	role	NOUN
admet-2774	299	23	of	of	ADP
admet-2774	299	24	mitochondrial	mitochondrial	ADJ
admet-2774	299	25	stress	stress	NOUN
admet-2774	299	26	.	.	PUNCT
admet-2774	300	1	journal	journal	NOUN
admet-2774	300	2	of	of	ADP
admet-2774	300	3	gastroenterology	gastroenterology	NOUN
admet-2774	300	4	and	and	CCONJ
admet-2774	300	5	hepatology	hepatology	NOUN
admet-2774	300	6	29	29	NUM
admet-2774	300	7	(	(	PUNCT
admet-2774	300	8	2014	2014	NUM
admet-2774	300	9	)	)	PUNCT
admet-2774	300	10	678	678	NUM
admet-2774	300	11	-	-	SYM
admet-2774	300	12	687	687	NUM
admet-2774	300	13	.	.	PUNCT
admet-2774	301	1	https://doi.org/10.1111/jgh.12516	https://doi.org/10.1111/jgh.12516	PROPN
admet-2774	302	1	[	[	X
admet-2774	302	2	11	11	NUM
admet-2774	302	3	]	]	PUNCT
admet-2774	302	4	t.	t.	PROPN
admet-2774	302	5	schaberg	schaberg	PROPN
admet-2774	302	6	,	,	PUNCT
admet-2774	302	7	k.	k.	PROPN
admet-2774	302	8	rebhan	rebhan	PROPN
admet-2774	302	9	,	,	PUNCT
admet-2774	302	10	h.	h.	PROPN
admet-2774	302	11	lode	lode	PROPN
admet-2774	302	12	.	.	PUNCT
admet-2774	303	1	risk	risk	NOUN
admet-2774	303	2	factors	factor	NOUN
admet-2774	303	3	for	for	ADP
admet-2774	303	4	side	side	NOUN
admet-2774	303	5	-	-	PUNCT
admet-2774	303	6	effects	effect	NOUN
admet-2774	303	7	of	of	ADP
admet-2774	303	8	isoniazid	isoniazid	NOUN
admet-2774	303	9	,	,	PUNCT
admet-2774	303	10	rifampin	rifampin	VERB
admet-2774	303	11	and	and	CCONJ
admet-2774	303	12	pyrazinamide	pyrazinamide	VERB
admet-2774	303	13	in	in	ADP
admet-2774	303	14	patients	patient	NOUN
admet-2774	303	15	hospitalized	hospitalize	VERB
admet-2774	303	16	for	for	ADP
admet-2774	303	17	pulmonary	pulmonary	ADJ
admet-2774	303	18	tuberculosis	tuberculosis	NOUN
admet-2774	303	19	.	.	PUNCT
admet-2774	304	1	european	european	ADJ
admet-2774	304	2	respiratory	respiratory	ADJ
admet-2774	304	3	journal	journal	NOUN
admet-2774	304	4	9	9	NUM
admet-2774	304	5	(	(	PUNCT
admet-2774	304	6	1996	1996	NUM
admet-2774	304	7	)	)	PUNCT
admet-2774	304	8	20262030	20262030	NUM
admet-2774	304	9	.	.	PUNCT
admet-2774	304	10	https://doi.org/10.1080/07373937.2024.2437691	https://doi.org/10.1080/07373937.2024.2437691	PUNCT
admet-2774	305	1	[	[	X
admet-2774	305	2	12	12	NUM
admet-2774	305	3	]	]	PUNCT
admet-2774	305	4	k.	k.	PROPN
admet-2774	305	5	jadhav	jadhav	PROPN
admet-2774	305	6	,	,	PUNCT
admet-2774	305	7	e.	e.	PROPN
admet-2774	305	8	kole	kole	PROPN
admet-2774	305	9	,	,	PUNCT
admet-2774	305	10	a.	a.	NOUN
admet-2774	305	11	abhang	abhang	PROPN
admet-2774	305	12	,	,	PUNCT
admet-2774	305	13	s.	s.	PROPN
admet-2774	305	14	rojekar	rojekar	PROPN
admet-2774	305	15	,	,	PUNCT
admet-2774	305	16	v.	v.	ADP
admet-2774	305	17	sugandhi	sugandhi	PROPN
admet-2774	305	18	,	,	PUNCT
admet-2774	305	19	r.k	r.k	PROPN
admet-2774	305	20	.	.	PROPN
admet-2774	305	21	verma	verma	PROPN
admet-2774	305	22	,	,	PUNCT
admet-2774	305	23	a.	a.	PROPN
admet-2774	305	24	mujumdar	mujumdar	PROPN
admet-2774	305	25	,	,	PUNCT
admet-2774	305	26	j.	j.	PROPN
admet-2774	305	27	naik	naik	PROPN
admet-2774	305	28	.	.	PUNCT
admet-2774	306	1	revealing	reveal	VERB
admet-2774	306	2	the	the	DET
admet-2774	306	3	potential	potential	NOUN
admet-2774	306	4	of	of	ADP
admet-2774	306	5	nano	nano	NOUN
admet-2774	306	6	spray	spray	NOUN
admet-2774	306	7	drying	dry	VERB
admet-2774	306	8	for	for	ADP
admet-2774	306	9	effective	effective	ADJ
admet-2774	306	10	delivery	delivery	NOUN
admet-2774	306	11	of	of	ADP
admet-2774	306	12	pharmaceuticals	pharmaceutical	NOUN
admet-2774	306	13	and	and	CCONJ
admet-2774	306	14	biologicals	biological	NOUN
admet-2774	306	15	.	.	PUNCT
admet-2774	307	1	drying	dry	VERB
admet-2774	307	2	technology	technology	NOUN
admet-2774	307	3	(	(	PUNCT
admet-2774	307	4	2024	2024	NUM
admet-2774	307	5	)	)	PUNCT
admet-2774	307	6	90	90	NUM
admet-2774	307	7	-	-	SYM
admet-2774	307	8	113	113	NUM
admet-2774	307	9	.	.	PUNCT
admet-2774	307	10	https://doi.org/10.1080/07373937.2024.2437691	https://doi.org/10.1080/07373937.2024.2437691	PUNCT
admet-2774	308	1	[	[	X
admet-2774	308	2	13	13	NUM
admet-2774	308	3	]	]	X
admet-2774	308	4	s.r	s.r	PROPN
admet-2774	308	5	.	.	PROPN
admet-2774	308	6	pardeshi	pardeshi	PROPN
admet-2774	308	7	,	,	PUNCT
admet-2774	308	8	e.b	e.b	PROPN
admet-2774	308	9	.	.	PROPN
admet-2774	308	10	kole	kole	PROPN
admet-2774	308	11	,	,	PUNCT
admet-2774	308	12	h.s	h.s	PROPN
admet-2774	308	13	.	.	PROPN
admet-2774	308	14	kapare	kapare	PROPN
admet-2774	308	15	,	,	PUNCT
admet-2774	308	16	s.m	s.m	PROPN
admet-2774	308	17	.	.	PROPN
admet-2774	308	18	chandankar	chandankar	PROPN
admet-2774	308	19	,	,	PUNCT
admet-2774	308	20	p.j	p.j	PROPN
admet-2774	308	21	.	.	PROPN
admet-2774	308	22	shinde	shinde	PROPN
admet-2774	308	23	,	,	PUNCT
admet-2774	308	24	g.s	g.s	PROPN
admet-2774	308	25	.	.	PROPN
admet-2774	308	26	boisa	boisa	PROPN
admet-2774	308	27	,	,	PUNCT
admet-2774	308	28	s.s	s.s	PROPN
admet-2774	308	29	.	.	PROPN
admet-2774	308	30	salgaonkar	salgaonkar	PROPN
admet-2774	308	31	,	,	PUNCT
admet-2774	308	32	p.s	p.s	PROPN
admet-2774	308	33	.	.	PROPN
admet-2774	308	34	giram	giram	PROPN
admet-2774	308	35	,	,	PUNCT
admet-2774	308	36	m.p	m.p	PROPN
admet-2774	308	37	.	.	PROPN
admet-2774	308	38	more	more	ADJ
admet-2774	308	39	,	,	PUNCT
admet-2774	308	40	p.	p.	PROPN
admet-2774	308	41	kolimi	kolimi	PROPN
admet-2774	308	42	,	,	PUNCT
admet-2774	308	43	d.	d.	PROPN
admet-2774	308	44	nyavanandi	nyavanandi	PROPN
admet-2774	308	45	,	,	PUNCT
admet-2774	308	46	s.	s.	PROPN
admet-2774	308	47	dyawanapelly	dyawanapelly	PROPN
admet-2774	308	48	,	,	PUNCT
admet-2774	308	49	v.	v.	ADP
admet-2774	308	50	junnuthula	junnuthula	PROPN
admet-2774	308	51	.	.	PUNCT
admet-2774	309	1	progress	progress	NOUN
admet-2774	309	2	on	on	ADP
admet-2774	309	3	thin	thin	ADJ
admet-2774	309	4	film	film	NOUN
admet-2774	309	5	freezing	freeze	VERB
admet-2774	309	6	technology	technology	NOUN
admet-2774	309	7	for	for	ADP
admet-2774	309	8	dry	dry	ADJ
admet-2774	309	9	powder	powder	NOUN
admet-2774	309	10	inhalation	inhalation	NOUN
admet-2774	309	11	formulations	formulation	NOUN
admet-2774	309	12	.	.	PUNCT
admet-2774	310	1	pharmaceutics	pharmaceutic	NOUN
admet-2774	310	2	14	14	NUM
admet-2774	310	3	(	(	PUNCT
admet-2774	310	4	2022	2022	NUM
admet-2774	310	5	)	)	PUNCT
admet-2774	310	6	2632	2632	NUM
admet-2774	310	7	.	.	PUNCT
admet-2774	311	1	https://doi.org/10.3390/pharmaceutics14122632	https://doi.org/10.3390/pharmaceutics14122632	PROPN
admet-2774	312	1	[	[	X
admet-2774	312	2	14	14	NUM
admet-2774	312	3	]	]	X
admet-2774	312	4	e.	e.	PROPN
admet-2774	312	5	kole	kole	PROPN
admet-2774	312	6	,	,	PUNCT
admet-2774	312	7	k.	k.	PROPN
admet-2774	312	8	jadhav	jadhav	PROPN
admet-2774	312	9	,	,	PUNCT
admet-2774	312	10	n.	n.	PROPN
admet-2774	312	11	shirsath	shirsath	PROPN
admet-2774	312	12	,	,	PUNCT
admet-2774	312	13	p.	p.	PROPN
admet-2774	312	14	dudhe	dudhe	PROPN
admet-2774	312	15	,	,	PUNCT
admet-2774	312	16	r.k	r.k	PROPN
admet-2774	312	17	.	.	PROPN
admet-2774	312	18	verma	verma	PROPN
admet-2774	312	19	,	,	PUNCT
admet-2774	312	20	a.	a.	NOUN
admet-2774	312	21	chatterjee	chatterjee	PROPN
admet-2774	312	22	,	,	PUNCT
admet-2774	312	23	j.	j.	PROPN
admet-2774	312	24	naik	naik	PROPN
admet-2774	312	25	.	.	PROPN
admet-2774	312	26	nanotherapeutics	nanotherapeutics	PROPN
admet-2774	312	27	for	for	ADP
admet-2774	312	28	pulmonary	pulmonary	ADJ
admet-2774	312	29	drug	drug	NOUN
admet-2774	312	30	delivery	delivery	NOUN
admet-2774	312	31	:	:	PUNCT
admet-2774	312	32	an	an	DET
admet-2774	312	33	emerging	emerge	VERB
admet-2774	312	34	approach	approach	NOUN
admet-2774	312	35	to	to	PART
admet-2774	312	36	overcome	overcome	VERB
admet-2774	312	37	respiratory	respiratory	ADJ
admet-2774	312	38	diseases	disease	NOUN
admet-2774	312	39	.	.	PUNCT
admet-2774	313	1	journal	journal	NOUN
admet-2774	313	2	of	of	ADP
admet-2774	313	3	drug	drug	NOUN
admet-2774	313	4	delivery	delivery	NOUN
admet-2774	313	5	science	science	NOUN
admet-2774	313	6	and	and	CCONJ
admet-2774	313	7	technology	technology	NOUN
admet-2774	313	8	81	81	NUM
admet-2774	313	9	(	(	PUNCT
admet-2774	313	10	2023	2023	NUM
admet-2774	313	11	)	)	PUNCT
admet-2774	313	12	104261	104261	NUM
admet-2774	313	13	.	.	PUNCT
admet-2774	314	1	https://doi.org/10.1016/j.jddst.2023.104261	https://doi.org/10.1016/j.jddst.2023.104261	NOUN
admet-2774	314	2	[	[	X
admet-2774	314	3	15	15	NUM
admet-2774	314	4	]	]	PUNCT
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admet-2774	314	7	,	,	PUNCT
admet-2774	314	8	e.	e.	PROPN
admet-2774	314	9	kole	kole	PROPN
admet-2774	314	10	,	,	PUNCT
admet-2774	314	11	r.	r.	PROPN
admet-2774	314	12	singh	singh	PROPN
admet-2774	314	13	,	,	PUNCT
admet-2774	314	14	s.k	s.k	PROPN
admet-2774	314	15	.	.	PROPN
admet-2774	314	16	rout	rout	PROPN
admet-2774	314	17	,	,	PUNCT
admet-2774	314	18	r.k	r.k	PROPN
admet-2774	314	19	.	.	PROPN
admet-2774	314	20	verma	verma	PROPN
admet-2774	314	21	,	,	PUNCT
admet-2774	314	22	a.	a.	NOUN
admet-2774	314	23	chatterjee	chatterjee	PROPN
admet-2774	314	24	,	,	PUNCT
admet-2774	314	25	a.	a.	PROPN
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admet-2774	314	27	,	,	PUNCT
admet-2774	314	28	j.	j.	PROPN
admet-2774	314	29	naik	naik	PROPN
admet-2774	314	30	.	.	PUNCT
admet-2774	315	1	a	a	DET
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admet-2774	315	4	on	on	ADP
admet-2774	315	5	developments	development	NOUN
admet-2774	315	6	in	in	ADP
admet-2774	315	7	drying	dry	VERB
admet-2774	315	8	technologies	technology	NOUN
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admet-2774	315	16	.	.	PUNCT
admet-2774	316	1	drying	dry	VERB
admet-2774	316	2	technology	technology	NOUN
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admet-2774	316	4	(	(	PUNCT
admet-2774	316	5	2024	2024	NUM
admet-2774	316	6	)	)	PUNCT
admet-2774	316	7	1415	1415	NUM
admet-2774	316	8	-	-	SYM
admet-2774	316	9	1441	1441	NUM
admet-2774	316	10	.	.	PUNCT
admet-2774	317	1	https://doi.org/10.1080/07373937.2024.2357181	https://doi.org/10.1080/07373937.2024.2357181	PROPN
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admet-2774	318	2	16	16	NUM
admet-2774	318	3	]	]	X
admet-2774	318	4	e.	e.	PROPN
admet-2774	318	5	kole	kole	PROPN
admet-2774	318	6	,	,	PUNCT
admet-2774	318	7	k.	k.	PROPN
admet-2774	318	8	jadhav	jadhav	PROPN
admet-2774	318	9	,	,	PUNCT
admet-2774	318	10	y.	y.	PROPN
admet-2774	318	11	sonar	sonar	PROPN
admet-2774	318	12	,	,	PUNCT
admet-2774	318	13	m.	m.	NOUN
admet-2774	318	14	kapse	kapse	NOUN
admet-2774	318	15	,	,	PUNCT
admet-2774	318	16	s.a	s.a	PROPN
admet-2774	318	17	.	.	PROPN
admet-2774	318	18	patil	patil	PROPN
admet-2774	318	19	,	,	PUNCT
admet-2774	318	20	a.	a.	PROPN
admet-2774	318	21	kumar	kumar	PROPN
admet-2774	318	22	.	.	PROPN
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admet-2774	318	25	spray	spray	NOUN
admet-2774	318	26	drying	dry	VERB
admet-2774	318	27	technology	technology	NOUN
admet-2774	318	28	for	for	ADP
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admet-2774	318	30	-	-	ADJ
admet-2774	318	31	tubercular	tubercular	ADJ
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admet-2774	318	33	development	development	NOUN
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admet-2774	318	35	:	:	PUNCT
admet-2774	318	36	a	a	DET
admet-2774	318	37	comprehensive	comprehensive	ADJ
admet-2774	318	38	review	review	NOUN
admet-2774	318	39	.	.	PUNCT
admet-2774	319	1	drying	dry	VERB
admet-2774	319	2	technology	technology	NOUN
admet-2774	319	3	43(1	43(1	NOUN
admet-2774	319	4	-	-	SYM
admet-2774	319	5	2	2	NUM
admet-2774	319	6	)	)	PUNCT
admet-2774	319	7	(	(	PUNCT
admet-2774	319	8	2025	2025	NUM
admet-2774	319	9	)	)	PUNCT
admet-2774	319	10	53	53	NUM
admet-2774	319	11	-	-	SYM
admet-2774	319	12	89	89	NUM
admet-2774	319	13	.	.	PUNCT
admet-2774	319	14	https://doi.org/10.1080/07373937.2024.2437690	https://doi.org/10.1080/07373937.2024.2437690	PROPN
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admet-2774	320	2	17	17	NUM
admet-2774	320	3	]	]	X
admet-2774	320	4	v.	v.	PROPN
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admet-2774	320	6	,	,	PUNCT
admet-2774	320	7	a.	a.	PROPN
admet-2774	320	8	roy	roy	PROPN
admet-2774	320	9	,	,	PUNCT
admet-2774	320	10	k.	k.	PROPN
admet-2774	320	11	kaur	kaur	PROPN
admet-2774	320	12	,	,	PUNCT
admet-2774	320	13	a.	a.	PROPN
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admet-2774	320	15	,	,	PUNCT
admet-2774	320	16	k.	k.	PROPN
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admet-2774	320	18	,	,	PUNCT
admet-2774	320	19	r.	r.	PROPN
admet-2774	320	20	verma	verma	PROPN
admet-2774	320	21	,	,	PUNCT
admet-2774	320	22	s.	s.	PROPN
admet-2774	320	23	rustagi	rustagi	PROPN
admet-2774	320	24	,	,	PUNCT
admet-2774	320	25	s.	s.	PROPN
admet-2774	320	26	malik	malik	PROPN
admet-2774	320	27	.	.	PUNCT
admet-2774	321	1	current	current	ADJ
admet-2774	321	2	advancements	advancement	NOUN
admet-2774	321	3	in	in	ADP
admet-2774	321	4	functional	functional	ADJ
admet-2774	321	5	nanomaterials	nanomaterial	NOUN
admet-2774	321	6	for	for	ADP
admet-2774	321	7	drug	drug	NOUN
admet-2774	321	8	delivery	delivery	NOUN
admet-2774	321	9	systems	system	NOUN
admet-2774	321	10	.	.	PUNCT
admet-2774	322	1	nano	nano	NOUN
admet-2774	322	2	-	-	PUNCT
admet-2774	322	3	structures	structure	NOUN
admet-2774	322	4	&	&	CCONJ
admet-2774	322	5	nano	nano	NOUN
admet-2774	322	6	-	-	PUNCT
admet-2774	322	7	objects	object	VERB
admet-2774	322	8	38	38	NUM
admet-2774	322	9	(	(	PUNCT
admet-2774	322	10	2024	2024	NUM
admet-2774	322	11	)	)	PUNCT
admet-2774	322	12	101177	101177	NUM
admet-2774	322	13	.	.	PUNCT
admet-2774	323	1	https://doi.org/10.1016/j.nanoso.2024.101177	https://doi.org/10.1016/j.nanoso.2024.101177	ADJ
admet-2774	323	2	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	323	3	https://doi.org/10.1016/j.vaccine.2024.04.055	https://doi.org/10.1016/j.vaccine.2024.04.055	X
admet-2774	323	4	https://doi.org/10.1128/cmr.00036-20	https://doi.org/10.1128/cmr.00036-20	CCONJ
admet-2774	323	5	https://doi.org/10.1111/resp.13346	https://doi.org/10.1111/resp.13346	ADJ
admet-2774	323	6	https://doi.org/10.1007/s00284-024-03853-z	https://doi.org/10.1007/s00284-024-03853-z	NOUN
admet-2774	323	7	https://doi.org/10.1016/j.ijpharm.2024.123920	https://doi.org/10.1016/j.ijpharm.2024.123920	ADV
admet-2774	323	8	https://doi.org/10.2147/ppa.s258292	https://doi.org/10.2147/ppa.s258292	NUM
admet-2774	323	9	https://doi.org/10.3389/fphar.2021.625078	https://doi.org/10.3389/fphar.2021.625078	PROPN
admet-2774	323	10	https://doi.org/10.1111/jgh.12516	https://doi.org/10.1111/jgh.12516	PROPN
admet-2774	323	11	https://doi.org/10.1080/07373937.2024.2437691	https://doi.org/10.1080/07373937.2024.2437691	PUNCT
admet-2774	323	12	https://doi.org/10.1080/07373937.2024.2437691	https://doi.org/10.1080/07373937.2024.2437691	PROPN
admet-2774	323	13	https://doi.org/10.3390/pharmaceutics14122632	https://doi.org/10.3390/pharmaceutics14122632	PROPN
admet-2774	323	14	https://doi.org/10.1016/j.jddst.2023.104261	https://doi.org/10.1016/j.jddst.2023.104261	PROPN
admet-2774	323	15	https://doi.org/10.1080/07373937.2024.2357181	https://doi.org/10.1080/07373937.2024.2357181	PROPN
admet-2774	323	16	https://doi.org/10.1080/07373937.2024.2437690	https://doi.org/10.1080/07373937.2024.2437690	PROPN
admet-2774	324	1	https://doi.org/10.1016/j.nanoso.2024.101177	https://doi.org/10.1016/j.nanoso.2024.101177	PROPN
admet-2774	324	2	e.	e.	PROPN
admet-2774	324	3	kole	kole	PROPN
admet-2774	324	4	et	et	PROPN
admet-2774	324	5	al	al	PROPN
admet-2774	324	6	.	.	PROPN
admet-2774	324	7	admet	admet	PROPN
admet-2774	324	8	&	&	CCONJ
admet-2774	324	9	dmpk	dmpk	PROPN
admet-2774	324	10	13(4	13(4	NUM
admet-2774	324	11	)	)	PUNCT
admet-2774	324	12	(	(	PUNCT
admet-2774	324	13	2025	2025	NUM
admet-2774	324	14	)	)	PUNCT
admet-2774	324	15	2774	2774	NUM
admet-2774	324	16	16	16	NUM
admet-2774	325	1	[	[	X
admet-2774	325	2	18	18	NUM
admet-2774	325	3	]	]	PUNCT
admet-2774	325	4	g.	g.	PROPN
admet-2774	325	5	wyszogrodzka	wyszogrodzka	PROPN
admet-2774	325	6	-	-	PUNCT
admet-2774	325	7	gaweł	gaweł	PROPN
admet-2774	325	8	,	,	PUNCT
admet-2774	325	9	p.	p.	PROPN
admet-2774	325	10	dorożyński	dorożyński	PROPN
admet-2774	325	11	,	,	PUNCT
admet-2774	325	12	s.	s.	PROPN
admet-2774	325	13	giovagnoli	giovagnoli	PROPN
admet-2774	325	14	,	,	PUNCT
admet-2774	325	15	w.	w.	PROPN
admet-2774	325	16	strzempek	strzempek	PROPN
admet-2774	325	17	,	,	PUNCT
admet-2774	325	18	e.	e.	PROPN
admet-2774	325	19	pesta	pesta	PROPN
admet-2774	325	20	,	,	PUNCT
admet-2774	325	21	w.p	w.p	PROPN
admet-2774	325	22	.	.	PROPN
admet-2774	325	23	węglarz	węglarz	PROPN
admet-2774	325	24	,	,	PUNCT
admet-2774	325	25	b.	b.	PROPN
admet-2774	325	26	gil	gil	PROPN
admet-2774	325	27	,	,	PUNCT
admet-2774	325	28	e.	e.	PROPN
admet-2774	325	29	menaszek	menaszek	PROPN
admet-2774	325	30	,	,	PUNCT
admet-2774	325	31	p.	p.	PROPN
admet-2774	325	32	kulinowski	kulinowski	PROPN
admet-2774	325	33	.	.	PUNCT
admet-2774	326	1	an	an	DET
admet-2774	326	2	inhalable	inhalable	ADJ
admet-2774	326	3	theranostic	theranostic	ADJ
admet-2774	326	4	system	system	NOUN
admet-2774	326	5	for	for	ADP
admet-2774	326	6	local	local	ADJ
admet-2774	326	7	tuberculosis	tuberculosis	NOUN
admet-2774	326	8	treatment	treatment	NOUN
admet-2774	326	9	containing	contain	VERB
admet-2774	326	10	an	an	DET
admet-2774	326	11	isoniazid	isoniazid	NOUN
admet-2774	326	12	loaded	load	VERB
admet-2774	326	13	metal	metal	NOUN
admet-2774	326	14	organic	organic	ADJ
admet-2774	326	15	framework	framework	NOUN
admet-2774	326	16	fe	fe	X
admet-2774	326	17	-	-	PUNCT
admet-2774	326	18	mil-101	mil-101	NOUN
admet-2774	326	19	-	-	PUNCT
admet-2774	326	20	nh2	nh2	NOUN
admet-2774	326	21	—	—	PUNCT
admet-2774	326	22	from	from	ADP
admet-2774	326	23	raw	raw	ADJ
admet-2774	326	24	mof	mof	NOUN
admet-2774	326	25	to	to	ADP
admet-2774	326	26	drug	drug	NOUN
admet-2774	326	27	delivery	delivery	NOUN
admet-2774	326	28	system	system	NOUN
admet-2774	326	29	.	.	PUNCT
admet-2774	327	1	pharmaceutics	pharmaceutic	NOUN
admet-2774	327	2	11	11	NUM
admet-2774	327	3	(	(	PUNCT
admet-2774	327	4	2019	2019	NUM
admet-2774	327	5	)	)	PUNCT
admet-2774	327	6	687	687	NUM
admet-2774	327	7	.	.	PUNCT
admet-2774	328	1	https://doi.org/10.3390/pharmaceutics11120687	https://doi.org/10.3390/pharmaceutics11120687	NOUN
admet-2774	328	2	[	[	X
admet-2774	328	3	19	19	NUM
admet-2774	328	4	]	]	X
admet-2774	328	5	l.c	l.c	PROPN
admet-2774	328	6	.	.	PROPN
admet-2774	328	7	luciani	luciani	PROPN
admet-2774	328	8	-	-	PUNCT
admet-2774	328	9	giacobbe	giacobbe	NOUN
admet-2774	328	10	,	,	PUNCT
admet-2774	328	11	a.m.	a.m.	PROPN
admet-2774	328	12	lorenzutti	lorenzutti	PROPN
admet-2774	328	13	,	,	PUNCT
admet-2774	328	14	n.j	n.j	PROPN
admet-2774	328	15	.	.	PROPN
admet-2774	328	16	litterio	litterio	PROPN
admet-2774	328	17	,	,	PUNCT
admet-2774	328	18	m.v	m.v	PROPN
admet-2774	328	19	.	.	PROPN
admet-2774	328	20	ramírez	ramírez	PROPN
admet-2774	328	21	-	-	PUNCT
admet-2774	328	22	rigo	rigo	PROPN
admet-2774	328	23	,	,	PUNCT
admet-2774	328	24	m.e	m.e	PROPN
admet-2774	328	25	.	.	PROPN
admet-2774	328	26	olivera	olivera	PROPN
admet-2774	328	27	.	.	PUNCT
admet-2774	329	1	antituberculosis	antituberculosis	PROPN
admet-2774	329	2	site	site	NOUN
admet-2774	329	3	-	-	PUNCT
admet-2774	329	4	specific	specific	ADJ
admet-2774	329	5	oral	oral	ADJ
admet-2774	329	6	delivery	delivery	NOUN
admet-2774	329	7	system	system	NOUN
admet-2774	329	8	that	that	PRON
admet-2774	329	9	enhances	enhance	VERB
admet-2774	329	10	rifampicin	rifampicin	VERB
admet-2774	329	11	bioavailability	bioavailability	NOUN
admet-2774	329	12	in	in	ADP
admet-2774	329	13	a	a	DET
admet-2774	329	14	fixed	fix	VERB
admet-2774	329	15	-	-	PUNCT
admet-2774	329	16	dose	dose	NOUN
admet-2774	329	17	combination	combination	NOUN
admet-2774	329	18	with	with	ADP
admet-2774	329	19	isoniazid	isoniazid	NOUN
admet-2774	329	20	.	.	PUNCT
admet-2774	330	1	drug	drug	NOUN
admet-2774	330	2	delivery	delivery	NOUN
admet-2774	330	3	and	and	CCONJ
admet-2774	330	4	translational	translational	ADJ
admet-2774	330	5	research	research	NOUN
admet-2774	330	6	11	11	NUM
admet-2774	330	7	(	(	PUNCT
admet-2774	330	8	2021	2021	NUM
admet-2774	330	9	)	)	PUNCT
admet-2774	330	10	894	894	NUM
admet-2774	330	11	-	-	SYM
admet-2774	330	12	908	908	NUM
admet-2774	330	13	.	.	PUNCT
admet-2774	331	1	https://doi.org/10.1007/s13346-020-00847-9	https://doi.org/10.1007/s13346-020-00847-9	PUNCT
admet-2774	332	1	[	[	X
admet-2774	332	2	20	20	NUM
admet-2774	332	3	]	]	X
admet-2774	332	4	j.k	j.k	PROPN
admet-2774	332	5	.	.	PROPN
admet-2774	332	6	patra	patra	PROPN
admet-2774	332	7	,	,	PUNCT
admet-2774	332	8	g.	g.	PROPN
admet-2774	332	9	das	das	PROPN
admet-2774	332	10	,	,	PUNCT
admet-2774	332	11	l.f	l.f	PROPN
admet-2774	332	12	.	.	PROPN
admet-2774	332	13	fraceto	fraceto	PROPN
admet-2774	332	14	,	,	PUNCT
admet-2774	332	15	e.v.r	e.v.r	PROPN
admet-2774	332	16	.	.	PROPN
admet-2774	332	17	campos	campos	PROPN
admet-2774	332	18	,	,	PUNCT
admet-2774	332	19	m.	m.	NOUN
admet-2774	332	20	del	del	PROPN
admet-2774	332	21	p.	p.	PROPN
admet-2774	332	22	rodriguez	rodriguez	PROPN
admet-2774	332	23	-	-	PUNCT
admet-2774	332	24	torres	torre	NOUN
admet-2774	332	25	,	,	PUNCT
admet-2774	332	26	l.s	l.s	NOUN
admet-2774	332	27	.	.	PROPN
admet-2774	332	28	acosta	acosta	PROPN
admet-2774	332	29	-	-	PUNCT
admet-2774	332	30	torres	torre	NOUN
admet-2774	332	31	,	,	PUNCT
admet-2774	332	32	l.a	l.a	PROPN
admet-2774	332	33	.	.	PROPN
admet-2774	332	34	diaz	diaz	PROPN
admet-2774	332	35	-	-	PUNCT
admet-2774	332	36	torres	torres	PROPN
admet-2774	332	37	,	,	PUNCT
admet-2774	332	38	r.	r.	PROPN
admet-2774	332	39	grillo	grillo	PROPN
admet-2774	332	40	,	,	PUNCT
admet-2774	332	41	m.k	m.k	PROPN
admet-2774	332	42	.	.	PROPN
admet-2774	332	43	swamy	swamy	PROPN
admet-2774	332	44	,	,	PUNCT
admet-2774	332	45	s.	s.	PROPN
admet-2774	332	46	sharma	sharma	PROPN
admet-2774	332	47	,	,	PUNCT
admet-2774	332	48	s.	s.	PROPN
admet-2774	332	49	habtemariam	habtemariam	PROPN
admet-2774	332	50	,	,	PUNCT
admet-2774	332	51	h.-s	h.-s	PROPN
admet-2774	332	52	.	.	PUNCT
admet-2774	333	1	shin	shin	PROPN
admet-2774	333	2	.	.	PUNCT
admet-2774	334	1	nano	nano	PROPN
admet-2774	334	2	based	base	VERB
admet-2774	334	3	drug	drug	NOUN
admet-2774	334	4	delivery	delivery	NOUN
admet-2774	334	5	systems	system	NOUN
admet-2774	334	6	:	:	PUNCT
admet-2774	334	7	recent	recent	ADJ
admet-2774	334	8	developments	development	NOUN
admet-2774	334	9	and	and	CCONJ
admet-2774	334	10	future	future	ADJ
admet-2774	334	11	prospects	prospect	NOUN
admet-2774	334	12	.	.	PUNCT
admet-2774	335	1	journal	journal	NOUN
admet-2774	335	2	of	of	ADP
admet-2774	335	3	nanobiotechnology	nanobiotechnology	NOUN
admet-2774	335	4	16	16	NUM
admet-2774	335	5	(	(	PUNCT
admet-2774	335	6	2018	2018	NUM
admet-2774	335	7	)	)	PUNCT
admet-2774	335	8	71	71	NUM
admet-2774	335	9	.	.	PUNCT
admet-2774	336	1	https://doi.org/10.1186/s12951-018-0392-8	https://doi.org/10.1186/s12951-018-0392-8	PROPN
admet-2774	337	1	[	[	X
admet-2774	337	2	21	21	NUM
admet-2774	337	3	]	]	PUNCT
admet-2774	337	4	m.	m.	NOUN
admet-2774	337	5	kumar	kumar	PROPN
admet-2774	337	6	,	,	PUNCT
admet-2774	337	7	t.	t.	PROPN
admet-2774	337	8	virmani	virmani	PROPN
admet-2774	337	9	,	,	PUNCT
admet-2774	337	10	g.	g.	PROPN
admet-2774	337	11	kumar	kumar	PROPN
admet-2774	337	12	,	,	PUNCT
admet-2774	337	13	r.	r.	PROPN
admet-2774	337	14	deshmukh	deshmukh	PROPN
admet-2774	337	15	,	,	PUNCT
admet-2774	337	16	a.	a.	PROPN
admet-2774	337	17	sharma	sharma	PROPN
admet-2774	337	18	,	,	PUNCT
admet-2774	337	19	s.	s.	PROPN
admet-2774	337	20	duarte	duarte	PROPN
admet-2774	337	21	,	,	PUNCT
admet-2774	337	22	p.	p.	PROPN
admet-2774	337	23	brandão	brandão	PROPN
admet-2774	337	24	,	,	PUNCT
admet-2774	337	25	p.	p.	PROPN
admet-2774	337	26	fonte	fonte	PROPN
admet-2774	337	27	.	.	PUNCT
admet-2774	338	1	nanocarriers	nanocarrier	NOUN
admet-2774	338	2	in	in	ADP
admet-2774	338	3	tuberculosis	tuberculosis	NOUN
admet-2774	338	4	treatment	treatment	NOUN
admet-2774	338	5	:	:	PUNCT
admet-2774	338	6	challenges	challenge	NOUN
admet-2774	338	7	and	and	CCONJ
admet-2774	338	8	delivery	delivery	NOUN
admet-2774	338	9	strategies	strategy	NOUN
admet-2774	338	10	.	.	PUNCT
admet-2774	339	1	pharmaceuticals	pharmaceutical	NOUN
admet-2774	339	2	16	16	NUM
admet-2774	339	3	(	(	PUNCT
admet-2774	339	4	2023	2023	NUM
admet-2774	339	5	)	)	PUNCT
admet-2774	339	6	1360	1360	NUM
admet-2774	339	7	.	.	PUNCT
admet-2774	340	1	https://doi.org/10.3390/ph16101360	https://doi.org/10.3390/ph16101360	X
admet-2774	341	1	[	[	X
admet-2774	341	2	22	22	NUM
admet-2774	341	3	]	]	X
admet-2774	341	4	b.	b.	PROPN
admet-2774	341	5	begines	begines	PROPN
admet-2774	341	6	,	,	PUNCT
admet-2774	341	7	t.	t.	PROPN
admet-2774	341	8	ortiz	ortiz	PROPN
admet-2774	341	9	,	,	PUNCT
admet-2774	341	10	m.	m.	NOUN
admet-2774	341	11	pérez	pérez	NOUN
admet-2774	341	12	-	-	PUNCT
admet-2774	341	13	aranda	aranda	NOUN
admet-2774	341	14	,	,	PUNCT
admet-2774	341	15	g.	g.	PROPN
admet-2774	341	16	martínez	martínez	PROPN
admet-2774	341	17	,	,	PUNCT
admet-2774	341	18	m.	m.	NOUN
admet-2774	341	19	merinero	merinero	NOUN
admet-2774	341	20	,	,	PUNCT
admet-2774	341	21	f.	f.	PROPN
admet-2774	341	22	argüelles	argüelle	NOUN
admet-2774	341	23	-	-	PUNCT
admet-2774	341	24	arias	aria	NOUN
admet-2774	341	25	,	,	PUNCT
admet-2774	341	26	a.	a.	NOUN
admet-2774	341	27	alcudia	alcudia	PROPN
admet-2774	341	28	.	.	PUNCT
admet-2774	342	1	polymeric	polymeric	ADJ
admet-2774	342	2	nanoparticles	nanoparticle	NOUN
admet-2774	342	3	for	for	ADP
admet-2774	342	4	drug	drug	NOUN
admet-2774	342	5	delivery	delivery	NOUN
admet-2774	342	6	:	:	PUNCT
admet-2774	342	7	recent	recent	ADJ
admet-2774	342	8	developments	development	NOUN
admet-2774	342	9	and	and	CCONJ
admet-2774	342	10	future	future	ADJ
admet-2774	342	11	prospects	prospect	NOUN
admet-2774	342	12	.	.	PUNCT
admet-2774	343	1	nanomaterials	nanomaterial	NOUN
admet-2774	343	2	10	10	NUM
admet-2774	343	3	(	(	PUNCT
admet-2774	343	4	2020	2020	NUM
admet-2774	343	5	)	)	PUNCT
admet-2774	343	6	1403	1403	NUM
admet-2774	343	7	.	.	PUNCT
admet-2774	344	1	https://doi.org/10.3390/nano10071403	https://doi.org/10.3390/nano10071403	VERB
admet-2774	344	2	[	[	X
admet-2774	344	3	23	23	NUM
admet-2774	344	4	]	]	X
admet-2774	344	5	l.	l.	PROPN
admet-2774	344	6	eltaib	eltaib	PROPN
admet-2774	344	7	.	.	PUNCT
admet-2774	345	1	polymeric	polymeric	ADJ
admet-2774	345	2	nanoparticles	nanoparticle	NOUN
admet-2774	345	3	in	in	ADP
admet-2774	345	4	targeted	target	VERB
admet-2774	345	5	drug	drug	NOUN
admet-2774	345	6	delivery	delivery	NOUN
admet-2774	345	7	:	:	PUNCT
admet-2774	345	8	unveiling	unveil	VERB
admet-2774	345	9	the	the	DET
admet-2774	345	10	impact	impact	NOUN
admet-2774	345	11	of	of	ADP
admet-2774	345	12	polymer	polymer	NOUN
admet-2774	345	13	characterization	characterization	NOUN
admet-2774	345	14	and	and	CCONJ
admet-2774	345	15	fabrication	fabrication	NOUN
admet-2774	345	16	.	.	PUNCT
admet-2774	346	1	polymers	polymer	NOUN
admet-2774	346	2	17	17	NUM
admet-2774	346	3	(	(	PUNCT
admet-2774	346	4	2025	2025	NUM
admet-2774	346	5	)	)	PUNCT
admet-2774	346	6	833	833	NUM
admet-2774	346	7	.	.	PUNCT
admet-2774	347	1	https://doi.org/10.3390/polym17070833	https://doi.org/10.3390/polym17070833	NOUN
admet-2774	348	1	[	[	X
admet-2774	348	2	24	24	NUM
admet-2774	348	3	]	]	X
admet-2774	348	4	r.	r.	PROPN
admet-2774	348	5	rajput	rajput	PROPN
admet-2774	348	6	,	,	PUNCT
admet-2774	348	7	j.	j.	PROPN
admet-2774	348	8	narkhede	narkhede	PROPN
admet-2774	348	9	,	,	PUNCT
admet-2774	348	10	j.b	j.b	PROPN
admet-2774	348	11	.	.	PROPN
admet-2774	349	1	naik	naik	PROPN
admet-2774	349	2	.	.	PUNCT
admet-2774	350	1	nanogels	nanogel	NOUN
admet-2774	350	2	as	as	ADP
admet-2774	350	3	nanocarriers	nanocarrier	NOUN
admet-2774	350	4	for	for	ADP
admet-2774	350	5	drug	drug	NOUN
admet-2774	350	6	delivery	delivery	NOUN
admet-2774	350	7	:	:	PUNCT
admet-2774	350	8	a	a	DET
admet-2774	350	9	review	review	NOUN
admet-2774	350	10	.	.	PUNCT
admet-2774	351	1	admet	admet	PROPN
admet-2774	351	2	and	and	CCONJ
admet-2774	351	3	dmpk	dmpk	X
admet-2774	351	4	8	8	NUM
admet-2774	351	5	(	(	PUNCT
admet-2774	351	6	2020	2020	NUM
admet-2774	351	7	)	)	PUNCT
admet-2774	351	8	1	1	NUM
admet-2774	351	9	-	-	SYM
admet-2774	351	10	15	15	NUM
admet-2774	351	11	.	.	PUNCT
admet-2774	352	1	https://doi.org/10.5599/admet.724	https://doi.org/10.5599/admet.724	NOUN
admet-2774	353	1	[	[	X
admet-2774	353	2	25	25	NUM
admet-2774	353	3	]	]	X
admet-2774	353	4	o.	o.	PROPN
admet-2774	353	5	opriș	opriș	PROPN
admet-2774	353	6	,	,	PUNCT
admet-2774	353	7	c.	c.	PROPN
admet-2774	353	8	mormile	mormile	PROPN
admet-2774	353	9	,	,	PUNCT
admet-2774	353	10	i.	i.	PROPN
admet-2774	353	11	lung	lung	PROPN
admet-2774	353	12	,	,	PUNCT
admet-2774	353	13	a.	a.	NOUN
admet-2774	353	14	stegarescu	stegarescu	PROPN
admet-2774	353	15	,	,	PUNCT
admet-2774	353	16	m.-l	m.-l	PROPN
admet-2774	353	17	.	.	PUNCT
admet-2774	354	1	soran	soran	PROPN
admet-2774	354	2	,	,	PUNCT
admet-2774	354	3	a.	a.	NOUN
admet-2774	354	4	soran	soran	PROPN
admet-2774	354	5	.	.	PUNCT
admet-2774	355	1	an	an	DET
admet-2774	355	2	overview	overview	NOUN
admet-2774	355	3	of	of	ADP
admet-2774	355	4	biopolymers	biopolymer	NOUN
admet-2774	355	5	for	for	ADP
admet-2774	355	6	drug	drug	NOUN
admet-2774	355	7	delivery	delivery	NOUN
admet-2774	355	8	applications	application	NOUN
admet-2774	355	9	.	.	PUNCT
admet-2774	356	1	applied	apply	VERB
admet-2774	356	2	sciences	science	NOUN
admet-2774	356	3	14	14	NUM
admet-2774	356	4	(	(	PUNCT
admet-2774	356	5	2024	2024	NUM
admet-2774	356	6	)	)	PUNCT
admet-2774	356	7	1383	1383	NUM
admet-2774	356	8	.	.	PUNCT
admet-2774	357	1	https://doi.org/10.3390/app14041383	https://doi.org/10.3390/app14041383	PROPN
admet-2774	357	2	[	[	X
admet-2774	357	3	26	26	NUM
admet-2774	357	4	]	]	PUNCT
admet-2774	357	5	t.-h	t.-h	NOUN
admet-2774	357	6	.	.	PUNCT
admet-2774	358	1	tsung	tsung	PROPN
admet-2774	358	2	,	,	PUNCT
admet-2774	358	3	y.-c	y.-c	PROPN
admet-2774	358	4	.	.	PUNCT
admet-2774	359	1	tsai	tsai	PROPN
admet-2774	359	2	,	,	PUNCT
admet-2774	359	3	h.-p	h.-p	PROPN
admet-2774	359	4	.	.	PUNCT
admet-2774	360	1	lee	lee	PROPN
admet-2774	360	2	,	,	PUNCT
admet-2774	360	3	y.-h	y.-h	PROPN
admet-2774	360	4	.	.	PUNCT
admet-2774	361	1	chen	chen	PROPN
admet-2774	361	2	,	,	PUNCT
admet-2774	361	3	d.-w	d.-w	PROPN
admet-2774	361	4	.	.	PUNCT
admet-2774	362	1	lu	lu	INTJ
admet-2774	362	2	.	.	PUNCT
admet-2774	363	1	biodegradable	biodegradable	ADJ
admet-2774	363	2	polymer	polymer	NOUN
admet-2774	363	3	-	-	PUNCT
admet-2774	363	4	based	base	VERB
admet-2774	363	5	drug	drug	NOUN
admet-2774	363	6	-	-	PUNCT
admet-2774	363	7	delivery	delivery	NOUN
admet-2774	363	8	systems	system	NOUN
admet-2774	363	9	for	for	ADP
admet-2774	363	10	ocular	ocular	ADJ
admet-2774	363	11	diseases	disease	NOUN
admet-2774	363	12	.	.	PUNCT
admet-2774	364	1	international	international	ADJ
admet-2774	364	2	journal	journal	NOUN
admet-2774	364	3	of	of	ADP
admet-2774	364	4	molecular	molecular	ADJ
admet-2774	364	5	sciences	science	NOUN
admet-2774	364	6	24	24	NUM
admet-2774	364	7	(	(	PUNCT
admet-2774	364	8	2023	2023	NUM
admet-2774	364	9	)	)	PUNCT
admet-2774	364	10	12976	12976	NUM
admet-2774	364	11	.	.	PUNCT
admet-2774	365	1	https://doi.org/10.3390/ijms241612976	https://doi.org/10.3390/ijms241612976	NOUN
admet-2774	366	1	[	[	X
admet-2774	366	2	27	27	NUM
admet-2774	366	3	]	]	X
admet-2774	366	4	e.	e.	PROPN
admet-2774	366	5	kole	kole	PROPN
admet-2774	366	6	,	,	PUNCT
admet-2774	366	7	k.	k.	PROPN
admet-2774	366	8	jadhav	jadhav	PROPN
admet-2774	366	9	,	,	PUNCT
admet-2774	366	10	z.	z.	PROPN
admet-2774	366	11	khan	khan	PROPN
admet-2774	366	12	,	,	PUNCT
admet-2774	366	13	r.k	r.k	PROPN
admet-2774	366	14	.	.	PROPN
admet-2774	366	15	verma	verma	PROPN
admet-2774	366	16	,	,	PUNCT
admet-2774	366	17	a.	a.	NOUN
admet-2774	366	18	chatterjee	chatterjee	PROPN
admet-2774	366	19	,	,	PUNCT
admet-2774	366	20	a.	a.	PROPN
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admet-2774	366	22	,	,	PUNCT
admet-2774	366	23	j.	j.	PROPN
admet-2774	366	24	naik	naik	PROPN
admet-2774	366	25	.	.	PROPN
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admet-2774	366	27	vildagliptinloaded	vildagliptinloade	VERB
admet-2774	366	28	polymeric	polymeric	ADJ
admet-2774	366	29	nanoparticles	nanoparticle	NOUN
admet-2774	366	30	via	via	ADP
admet-2774	366	31	microfluidic	microfluidic	NOUN
admet-2774	366	32	and	and	CCONJ
admet-2774	366	33	spray	spray	VERB
admet-2774	366	34	drying	dry	VERB
admet-2774	366	35	for	for	ADP
admet-2774	366	36	enhanced	enhanced	ADJ
admet-2774	366	37	antidiabetic	antidiabetic	ADJ
admet-2774	366	38	activity	activity	NOUN
admet-2774	366	39	.	.	PUNCT
admet-2774	367	1	future	future	ADJ
admet-2774	367	2	journal	journal	PROPN
admet-2774	367	3	of	of	ADP
admet-2774	367	4	pharmaceutical	pharmaceutical	ADJ
admet-2774	367	5	sciences	science	NOUN
admet-2774	367	6	10	10	NUM
admet-2774	367	7	(	(	PUNCT
admet-2774	367	8	2024	2024	NUM
admet-2774	367	9	)	)	PUNCT
admet-2774	367	10	156	156	NUM
admet-2774	367	11	.	.	PUNCT
admet-2774	368	1	https://doi.org/10.1186/s43094-02400736-9	https://doi.org/10.1186/s43094-02400736-9	PROPN
admet-2774	368	2	[	[	X
admet-2774	368	3	28	28	NUM
admet-2774	368	4	]	]	PUNCT
admet-2774	368	5	a.	a.	NOUN
admet-2774	368	6	patil	patil	PROPN
admet-2774	368	7	,	,	PUNCT
admet-2774	368	8	s.	s.	PROPN
admet-2774	368	9	pardeshi	pardeshi	PROPN
admet-2774	368	10	,	,	PUNCT
admet-2774	368	11	m.	m.	NOUN
admet-2774	368	12	kapase	kapase	NOUN
admet-2774	368	13	,	,	PUNCT
admet-2774	368	14	p.	p.	PROPN
admet-2774	368	15	patil	patil	PROPN
admet-2774	368	16	,	,	PUNCT
admet-2774	368	17	m.	m.	NOUN
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admet-2774	368	19	,	,	PUNCT
admet-2774	368	20	s.	s.	PROPN
admet-2774	368	21	dhole	dhole	PROPN
admet-2774	368	22	,	,	PUNCT
admet-2774	368	23	e.	e.	PROPN
admet-2774	368	24	kole	kole	PROPN
admet-2774	368	25	,	,	PUNCT
admet-2774	368	26	p.	p.	PROPN
admet-2774	368	27	deshmukh	deshmukh	PROPN
admet-2774	368	28	,	,	PUNCT
admet-2774	368	29	a.	a.	NOUN
admet-2774	368	30	gholap	gholap	PROPN
admet-2774	368	31	,	,	PUNCT
admet-2774	368	32	a.	a.	PROPN
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admet-2774	368	34	,	,	PUNCT
admet-2774	368	35	j.	j.	PROPN
admet-2774	368	36	naik	naik	PROPN
admet-2774	368	37	.	.	PUNCT
admet-2774	369	1	continuous	continuous	ADJ
admet-2774	369	2	preparation	preparation	NOUN
admet-2774	369	3	of	of	ADP
admet-2774	369	4	sustained	sustained	ADJ
admet-2774	369	5	release	release	NOUN
admet-2774	369	6	vildagliptin	vildagliptin	NOUN
admet-2774	369	7	nanoparticles	nanoparticle	NOUN
admet-2774	369	8	using	use	VERB
admet-2774	369	9	tubular	tubular	ADJ
admet-2774	369	10	microreactor	microreactor	NOUN
admet-2774	369	11	approach	approach	NOUN
admet-2774	369	12	.	.	PUNCT
admet-2774	370	1	drying	dry	VERB
admet-2774	370	2	technology	technology	NOUN
admet-2774	370	3	42(4	42(4	NOUN
admet-2774	370	4	)	)	PUNCT
admet-2774	370	5	(	(	PUNCT
admet-2774	370	6	2024	2024	NUM
admet-2774	370	7	)	)	PUNCT
admet-2774	370	8	661	661	NUM
admet-2774	370	9	-	-	SYM
admet-2774	370	10	673	673	NUM
admet-2774	370	11	.	.	PUNCT
admet-2774	371	1	https://doi.org/10.1080/07373937.2023.2298778	https://doi.org/10.1080/07373937.2023.2298778	X
admet-2774	372	1	[	[	X
admet-2774	372	2	29	29	NUM
admet-2774	372	3	]	]	PUNCT
admet-2774	372	4	s.	s.	PROPN
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admet-2774	372	6	,	,	PUNCT
admet-2774	372	7	r.	r.	PROPN
admet-2774	372	8	awasthi	awasthi	PROPN
admet-2774	372	9	,	,	PUNCT
admet-2774	372	10	a.	a.	NOUN
admet-2774	372	11	rohilla	rohilla	NOUN
admet-2774	372	12	,	,	PUNCT
admet-2774	372	13	s.k	s.k	PROPN
admet-2774	372	14	.	.	PROPN
admet-2774	372	15	singh	singh	PROPN
admet-2774	372	16	,	,	PUNCT
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admet-2774	372	18	.	.	PROPN
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admet-2774	372	20	,	,	PUNCT
admet-2774	372	21	k.	k.	PROPN
admet-2774	372	22	dua	dua	PROPN
admet-2774	372	23	,	,	PUNCT
admet-2774	372	24	h.	h.	PROPN
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admet-2774	372	26	.	.	PUNCT
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admet-2774	373	4	by	by	ADP
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admet-2774	373	6	-	-	PUNCT
admet-2774	373	7	behnken	behnken	VERB
admet-2774	373	8	design	design	NOUN
admet-2774	373	9	and	and	CCONJ
admet-2774	373	10	coating	coat	VERB
admet-2774	373	11	with	with	ADP
admet-2774	373	12	chitosan	chitosan	NOUN
admet-2774	373	13	:	:	PUNCT
admet-2774	373	14	a	a	DET
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admet-2774	373	16	approach	approach	NOUN
admet-2774	373	17	for	for	ADP
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admet-2774	373	19	drug	drug	NOUN
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admet-2774	373	21	.	.	PUNCT
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admet-2774	374	4	12(4	12(4	NUM
admet-2774	374	5	)	)	PUNCT
admet-2774	374	6	(	(	PUNCT
admet-2774	374	7	2024	2024	NUM
admet-2774	374	8	)	)	PUNCT
admet-2774	374	9	657	657	NUM
admet-2774	374	10	-	-	SYM
admet-2774	374	11	677	677	NUM
admet-2774	374	12	.	.	PUNCT
admet-2774	375	1	https://doi.org/10.5599/admet.2366	https://doi.org/10.5599/admet.2366	VERB
admet-2774	376	1	[	[	X
admet-2774	376	2	30	30	NUM
admet-2774	376	3	]	]	X
admet-2774	376	4	a.a	a.a	PROPN
admet-2774	376	5	.	.	PROPN
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admet-2774	376	9	.	.	PROPN
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admet-2774	376	11	.	.	PUNCT
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admet-2774	376	17	methotrexate	methotrexate	NOUN
admet-2774	376	18	loaded	load	VERB
admet-2774	376	19	niosomes	niosome	NOUN
admet-2774	376	20	for	for	ADP
admet-2774	376	21	enhanced	enhanced	ADJ
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admet-2774	376	23	of	of	ADP
admet-2774	376	24	psoriasis	psoriasis	NOUN
admet-2774	376	25	:	:	PUNCT
admet-2774	376	26	application	application	NOUN
admet-2774	376	27	of	of	ADP
admet-2774	376	28	box	box	NOUN
admet-2774	376	29	-	-	PUNCT
admet-2774	376	30	behnken	behnken	VERB
admet-2774	376	31	design	design	NOUN
admet-2774	376	32	,	,	PUNCT
admet-2774	376	33	in	in	ADP
admet-2774	376	34	-	-	PUNCT
admet-2774	376	35	vitro	vitro	X
admet-2774	376	36	evaluation	evaluation	NOUN
admet-2774	376	37	and	and	CCONJ
admet-2774	376	38	in	in	ADP
admet-2774	376	39	-	-	PUNCT
admet-2774	376	40	vivo	vivo	NOUN
admet-2774	376	41	skin	skin	NOUN
admet-2774	376	42	deposition	deposition	NOUN
admet-2774	376	43	study	study	NOUN
admet-2774	376	44	.	.	PUNCT
admet-2774	377	1	international	international	ADJ
admet-2774	377	2	journal	journal	PROPN
admet-2774	377	3	of	of	ADP
admet-2774	377	4	pharmaceutics	pharmaceutic	NOUN
admet-2774	377	5	485	485	NUM
admet-2774	377	6	(	(	PUNCT
admet-2774	377	7	2015	2015	NUM
admet-2774	377	8	)	)	PUNCT
admet-2774	377	9	235243	235243	NUM
admet-2774	377	10	.	.	PUNCT
admet-2774	378	1	https://doi.org/10.1016/j.ijpharm.2015.03.020	https://doi.org/10.1016/j.ijpharm.2015.03.020	NOUN
admet-2774	378	2	[	[	X
admet-2774	378	3	31	31	NUM
admet-2774	378	4	]	]	PUNCT
admet-2774	378	5	kole	kole	PROPN
admet-2774	378	6	,	,	PUNCT
admet-2774	378	7	e.	e.	PROPN
admet-2774	378	8	,	,	PUNCT
admet-2774	378	9	sonar	sonar	NOUN
admet-2774	378	10	,	,	PUNCT
admet-2774	378	11	y.	y.	PROPN
admet-2774	378	12	,	,	PUNCT
admet-2774	378	13	sarode	sarode	PROPN
admet-2774	378	14	,	,	PUNCT
admet-2774	378	15	r.	r.	PROPN
admet-2774	378	16	j.	j.	PROPN
admet-2774	378	17	,	,	PUNCT
admet-2774	378	18	chaudhari	chaudhari	PROPN
admet-2774	378	19	,	,	PUNCT
admet-2774	378	20	a.	a.	PROPN
admet-2774	378	21	,	,	PUNCT
admet-2774	378	22	&	&	CCONJ
admet-2774	378	23	naik	naik	PROPN
admet-2774	378	24	,	,	PUNCT
admet-2774	378	25	j.	j.	PROPN
admet-2774	378	26	(	(	PUNCT
admet-2774	378	27	2025	2025	NUM
admet-2774	378	28	)	)	PUNCT
admet-2774	378	29	.	.	PUNCT
admet-2774	379	1	development	development	NOUN
admet-2774	379	2	and	and	CCONJ
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admet-2774	379	4	of	of	ADP
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admet-2774	379	6	ethambutol	ethambutol	ADV
admet-2774	379	7	-	-	PUNCT
admet-2774	379	8	loaded	load	VERB
admet-2774	379	9	polymeric	polymeric	ADJ
admet-2774	379	10	nanoparticles	nanoparticle	NOUN
admet-2774	379	11	.	.	PUNCT
admet-2774	380	1	journal	journal	NOUN
admet-2774	380	2	of	of	ADP
admet-2774	380	3	applied	apply	VERB
admet-2774	380	4	pharmaceutical	pharmaceutical	ADJ
admet-2774	380	5	research	research	NOUN
admet-2774	380	6	13(2	13(2	PROPN
admet-2774	380	7	)	)	PUNCT
admet-2774	380	8	172	172	NUM
admet-2774	380	9	-	-	SYM
admet-2774	380	10	180	180	NUM
admet-2774	380	11	.	.	PUNCT
admet-2774	380	12	https://doi.org/10.69857/joapr.v13i2.1093	https://doi.org/10.69857/joapr.v13i2.1093	X
admet-2774	381	1	[	[	X
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admet-2774	381	3	]	]	X
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admet-2774	381	5	.	.	PUNCT
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admet-2774	381	7	,	,	PUNCT
admet-2774	381	8	r.k	r.k	PROPN
admet-2774	381	9	.	.	PROPN
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admet-2774	381	11	.	.	PUNCT
admet-2774	382	1	study	study	NOUN
admet-2774	382	2	of	of	ADP
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admet-2774	382	4	variables	variable	NOUN
admet-2774	382	5	influencing	influence	VERB
admet-2774	382	6	polymeric	polymeric	ADJ
admet-2774	382	7	microparticles	microparticle	NOUN
admet-2774	382	8	by	by	ADP
admet-2774	382	9	experimental	experimental	ADJ
admet-2774	382	10	design	design	NOUN
admet-2774	382	11	.	.	PUNCT
admet-2774	383	1	admet	admet	PROPN
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admet-2774	383	3	dmpk	dmpk	PROPN
admet-2774	383	4	2(1	2(1	NUM
admet-2774	383	5	)	)	PUNCT
admet-2774	383	6	(	(	PUNCT
admet-2774	383	7	2014	2014	NUM
admet-2774	383	8	)	)	PUNCT
admet-2774	383	9	63	63	NUM
admet-2774	383	10	-	-	SYM
admet-2774	383	11	70	70	NUM
admet-2774	383	12	.	.	PUNCT
admet-2774	384	1	https://doi.org/10.5599/admet.2.1.29	https://doi.org/10.5599/admet.2.1.29	PROPN
admet-2774	384	2	[	[	X
admet-2774	384	3	33	33	NUM
admet-2774	384	4	]	]	PUNCT
admet-2774	384	5	p.	p.	PROPN
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admet-2774	384	7	,	,	PUNCT
admet-2774	384	8	b.a	b.a	PROPN
admet-2774	384	9	.	.	PROPN
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admet-2774	384	11	,	,	PUNCT
admet-2774	384	12	h.y	h.y	PROPN
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admet-2774	384	19	,	,	PUNCT
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admet-2774	384	23	.	.	PUNCT
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admet-2774	385	12	-	-	PUNCT
admet-2774	385	13	resistant	resistant	ADJ
admet-2774	385	14	staphylococcus	staphylococcus	NOUN
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admet-2774	385	16	(	(	PUNCT
admet-2774	385	17	mrsa	mrsa	NOUN
admet-2774	385	18	)	)	PUNCT
admet-2774	385	19	harbored	harbor	VERB
admet-2774	385	20	inside	inside	ADP
admet-2774	385	21	https://doi.org/10.3390/pharmaceutics11120687	https://doi.org/10.3390/pharmaceutics11120687	NOUN
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admet-2774	386	8	https://doi.org/10.1186/s43094-024-00736-9	https://doi.org/10.1186/s43094-024-00736-9	NOUN
admet-2774	386	9	https://doi.org/10.1080/07373937.2023.2298778	https://doi.org/10.1080/07373937.2023.2298778	INTJ
admet-2774	386	10	https://doi.org/10.5599/admet.2366	https://doi.org/10.5599/admet.2366	PROPN
admet-2774	386	11	https://doi.org/10.1016/j.ijpharm.2015.03.020	https://doi.org/10.1016/j.ijpharm.2015.03.020	VERB
admet-2774	386	12	https://doi.org/10.69857/joapr.v13i2.1093	https://doi.org/10.69857/joapr.v13i2.1093	X
admet-2774	386	13	https://doi.org/10.5599/admet.2.1.29	https://doi.org/10.5599/admet.2.1.29	PROPN
admet-2774	386	14	admet	admet	PROPN
admet-2774	386	15	&	&	CCONJ
admet-2774	386	16	dmpk	dmpk	PROPN
admet-2774	386	17	13(4	13(4	NUM
admet-2774	386	18	)	)	PUNCT
admet-2774	386	19	(	(	PUNCT
admet-2774	386	20	2025	2025	NUM
admet-2774	386	21	)	)	PUNCT
admet-2774	386	22	2774	2774	NUM
admet-2774	386	23	freeze	freeze	NOUN
admet-2774	386	24	-	-	PUNCT
admet-2774	386	25	dried	dry	VERB
admet-2774	386	26	isoniazid	isoniazid	NOUN
admet-2774	386	27	-	-	PUNCT
admet-2774	386	28	loaded	load	VERB
admet-2774	386	29	poly	poly	ADJ
admet-2774	386	30	-	-	PUNCT
admet-2774	386	31	ε	ε	NOUN
admet-2774	386	32	-	-	PUNCT
admet-2774	386	33	caprolactone	caprolactone	ADJ
admet-2774	386	34	nanoparticles	nanoparticle	NOUN
admet-2774	386	35	doi	doi	NOUN
admet-2774	386	36	:	:	PUNCT
admet-2774	386	37	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	X
admet-2774	386	38	17	17	NUM
admet-2774	386	39	bone	bone	NOUN
admet-2774	386	40	cells	cell	NOUN
admet-2774	386	41	and	and	CCONJ
admet-2774	386	42	biofilms	biofilm	NOUN
admet-2774	386	43	.	.	PUNCT
admet-2774	387	1	european	european	PROPN
admet-2774	387	2	journal	journal	PROPN
admet-2774	387	3	of	of	ADP
admet-2774	387	4	pharmaceutics	pharmaceutic	NOUN
admet-2774	387	5	and	and	CCONJ
admet-2774	387	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2774	387	7	151	151	NUM
admet-2774	387	8	(	(	PUNCT
admet-2774	387	9	2020	2020	NUM
admet-2774	387	10	)	)	PUNCT
admet-2774	387	11	189198	189198	NUM
admet-2774	387	12	.	.	PUNCT
admet-2774	388	1	https://doi.org/10.1016/j.ejpb.2020.04.010	https://doi.org/10.1016/j.ejpb.2020.04.010	NOUN
admet-2774	388	2	[	[	X
admet-2774	388	3	34	34	NUM
admet-2774	388	4	]	]	X
admet-2774	388	5	l.	l.	PROPN
admet-2774	388	6	patil	patil	PROPN
admet-2774	388	7	,	,	PUNCT
admet-2774	388	8	u.	u.	PROPN
admet-2774	388	9	verma	verma	PROPN
admet-2774	388	10	,	,	PUNCT
admet-2774	388	11	r.	r.	PROPN
admet-2774	388	12	rajput	rajput	PROPN
admet-2774	388	13	,	,	PUNCT
admet-2774	388	14	p.	p.	PROPN
admet-2774	388	15	patil	patil	PROPN
admet-2774	388	16	,	,	PUNCT
admet-2774	388	17	a.	a.	PROPN
admet-2774	388	18	chaterjee	chaterjee	PROPN
admet-2774	388	19	,	,	PUNCT
admet-2774	388	20	j.b	j.b	PROPN
admet-2774	388	21	.	.	PROPN
admet-2774	389	1	naik	naik	PROPN
admet-2774	389	2	.	.	PUNCT
admet-2774	390	1	development	development	PROPN
admet-2774	390	2	of	of	ADP
admet-2774	390	3	olanzapine	olanzapine	PROPN
admet-2774	390	4	solid	solid	ADJ
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admet-2774	390	6	by	by	ADP
admet-2774	390	7	spray	spray	NOUN
admet-2774	390	8	drying	dry	VERB
admet-2774	390	9	technique	technique	NOUN
admet-2774	390	10	using	use	VERB
admet-2774	390	11	screening	screen	VERB
admet-2774	390	12	design	design	NOUN
admet-2774	390	13	for	for	ADP
admet-2774	390	14	solubility	solubility	NOUN
admet-2774	390	15	enhancement	enhancement	NOUN
admet-2774	390	16	.	.	PUNCT
admet-2774	391	1	admet	admet	PROPN
admet-2774	391	2	and	and	CCONJ
admet-2774	391	3	dmpk	dmpk	X
admet-2774	391	4	11	11	NUM
admet-2774	391	5	(	(	PUNCT
admet-2774	391	6	2023	2023	NUM
admet-2774	391	7	)	)	PUNCT
admet-2774	391	8	615	615	NUM
admet-2774	391	9	-	-	SYM
admet-2774	391	10	627	627	NUM
admet-2774	391	11	.	.	PUNCT
admet-2774	392	1	https://doi.org/10.5599/admet.1998	https://doi.org/10.5599/admet.1998	PRON
admet-2774	393	1	[	[	X
admet-2774	393	2	35	35	NUM
admet-2774	393	3	]	]	X
admet-2774	393	4	g.	g.	PROPN
admet-2774	393	5	khairnar	khairnar	PROPN
admet-2774	393	6	,	,	PUNCT
admet-2774	393	7	v.	v.	ADP
admet-2774	393	8	mokale	mokale	PROPN
admet-2774	393	9	,	,	PUNCT
admet-2774	393	10	r.	r.	PROPN
admet-2774	393	11	khairnar	khairnar	PROPN
admet-2774	393	12	,	,	PUNCT
admet-2774	393	13	a.	a.	PROPN
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admet-2774	393	15	,	,	PUNCT
admet-2774	393	16	j.	j.	PROPN
admet-2774	393	17	naik	naik	PROPN
admet-2774	393	18	.	.	PUNCT
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admet-2774	394	2	of	of	ADP
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admet-2774	394	4	and	and	CCONJ
admet-2774	394	5	antihypertensive	antihypertensive	ADJ
admet-2774	394	6	drug	drug	NOUN
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admet-2774	394	8	sustained	sustained	ADJ
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admet-2774	394	10	nanoparticles	nanoparticle	NOUN
admet-2774	394	11	using	use	VERB
admet-2774	394	12	spray	spray	NOUN
admet-2774	394	13	drying	dry	VERB
admet-2774	394	14	technique	technique	NOUN
admet-2774	394	15	:	:	PUNCT
admet-2774	394	16	optimization	optimization	NOUN
admet-2774	394	17	by	by	ADP
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admet-2774	394	21	.	.	PUNCT
admet-2774	395	1	drying	dry	VERB
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admet-2774	395	4	(	(	PUNCT
admet-2774	395	5	2022	2022	NUM
admet-2774	395	6	)	)	PUNCT
admet-2774	395	7	626	626	NUM
admet-2774	395	8	-	-	PUNCT
admet-2774	395	9	637	637	NUM
admet-2774	395	10	.	.	PUNCT
admet-2774	396	1	https://doi.org/10.1080/07373937.2020.1825292	https://doi.org/10.1080/07373937.2020.1825292	NOUN
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admet-2774	397	2	36	36	NUM
admet-2774	397	3	]	]	PUNCT
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admet-2774	397	9	,	,	PUNCT
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admet-2774	397	12	,	,	PUNCT
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admet-2774	397	14	patil	patil	PROPN
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admet-2774	397	21	,	,	PUNCT
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admet-2774	397	24	,	,	PUNCT
admet-2774	397	25	p.	p.	PROPN
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admet-2774	397	27	,	,	PUNCT
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admet-2774	398	12	.	.	PUNCT
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admet-2774	399	4	(	(	PUNCT
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admet-2774	399	6	)	)	PUNCT
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admet-2774	399	8	-	-	SYM
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admet-2774	399	10	.	.	PUNCT
admet-2774	400	1	https://doi.org/10.1080/07373937.2023.2298778	https://doi.org/10.1080/07373937.2023.2298778	PUNCT
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admet-2774	401	3	]	]	PUNCT
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admet-2774	401	6	-	-	PUNCT
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admet-2774	401	8	,	,	PUNCT
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admet-2774	401	14	.	.	PUNCT
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admet-2774	402	8	:	:	PUNCT
admet-2774	402	9	fabrication	fabrication	NOUN
admet-2774	402	10	,	,	PUNCT
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admet-2774	403	3	dmpk	dmpk	NOUN
admet-2774	403	4	11(4	11(4	NUM
admet-2774	403	5	)	)	PUNCT
admet-2774	403	6	(	(	PUNCT
admet-2774	403	7	2023	2023	NUM
admet-2774	403	8	)	)	PUNCT
admet-2774	403	9	587600	587600	NUM
admet-2774	403	10	.	.	PUNCT
admet-2774	404	1	https://doi.org/10.5599/admet.1740	https://doi.org/10.5599/admet.1740	PRON
admet-2774	405	1	[	[	X
admet-2774	405	2	38	38	NUM
admet-2774	405	3	]	]	PUNCT
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admet-2774	405	9	,	,	PUNCT
admet-2774	405	10	v.	v.	ADP
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admet-2774	405	14	chatterjee	chatterjee	PROPN
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admet-2774	406	14	polymeric	polymeric	ADJ
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admet-2774	406	19	to	to	PART
admet-2774	406	20	manage	manage	VERB
admet-2774	406	21	inflammation	inflammation	NOUN
admet-2774	406	22	.	.	PUNCT
admet-2774	407	1	drying	dry	VERB
admet-2774	407	2	technology	technology	NOUN
admet-2774	407	3	41	41	NUM
admet-2774	407	4	(	(	PUNCT
admet-2774	407	5	15	15	NUM
admet-2774	407	6	)	)	PUNCT
admet-2774	407	7	(	(	PUNCT
admet-2774	407	8	2023	2023	NUM
admet-2774	407	9	)	)	PUNCT
admet-2774	407	10	1	1	NUM
admet-2774	407	11	-	-	SYM
admet-2774	407	12	13	13	NUM
admet-2774	407	13	.	.	PUNCT
admet-2774	408	1	https://doi.org/10.1080/07373937.2023.2251572	https://doi.org/10.1080/07373937.2023.2251572	PUNCT
admet-2774	409	1	[	[	X
admet-2774	409	2	39	39	NUM
admet-2774	409	3	]	]	PUNCT
admet-2774	409	4	s.	s.	PROPN
admet-2774	409	5	mandpe	mandpe	PROPN
admet-2774	409	6	,	,	PUNCT
admet-2774	409	7	e.	e.	PROPN
admet-2774	409	8	kole	kole	PROPN
admet-2774	409	9	,	,	PUNCT
admet-2774	409	10	v.	v.	ADP
admet-2774	409	11	parate	parate	NOUN
admet-2774	409	12	,	,	PUNCT
admet-2774	409	13	a.	a.	NOUN
admet-2774	409	14	chatterjee	chatterjee	PROPN
admet-2774	409	15	,	,	PUNCT
admet-2774	409	16	a.	a.	PROPN
admet-2774	409	17	mujumdar	mujumdar	PROPN
admet-2774	409	18	,	,	PUNCT
admet-2774	409	19	j.	j.	PROPN
admet-2774	409	20	naik	naik	PROPN
admet-2774	409	21	.	.	PUNCT
admet-2774	410	1	development	development	PROPN
admet-2774	410	2	,	,	PUNCT
admet-2774	410	3	qbd	qbd	NOUN
admet-2774	410	4	-	-	PUNCT
admet-2774	410	5	based	base	VERB
admet-2774	410	6	optimisation	optimisation	NOUN
admet-2774	410	7	,	,	PUNCT
admet-2774	410	8	in	in	ADP
admet-2774	410	9	-	-	PUNCT
admet-2774	410	10	vivo	vivo	NOUN
admet-2774	410	11	pharmacokinetics	pharmacokinetic	NOUN
admet-2774	410	12	,	,	PUNCT
admet-2774	410	13	and	and	CCONJ
admet-2774	410	14	ex	ex	ADJ
admet-2774	410	15	-	-	ADJ
admet-2774	410	16	vivo	vivo	ADJ
admet-2774	410	17	evaluation	evaluation	NOUN
admet-2774	410	18	of	of	ADP
admet-2774	410	19	eudragit	eudragit	NOUN
admet-2774	410	20	®	®	NOUN
admet-2774	410	21	rs	rs	NOUN
admet-2774	410	22	100	100	NUM
admet-2774	410	23	loaded	load	VERB
admet-2774	410	24	flurbiprofen	flurbiprofen	NOUN
admet-2774	410	25	nanoparticles	nanoparticle	NOUN
admet-2774	410	26	for	for	ADP
admet-2774	410	27	oral	oral	ADJ
admet-2774	410	28	drug	drug	NOUN
admet-2774	410	29	delivery	delivery	NOUN
admet-2774	410	30	.	.	PUNCT
admet-2774	411	1	journal	journal	NOUN
admet-2774	411	2	of	of	ADP
admet-2774	411	3	microencapsulation	microencapsulation	NOUN
admet-2774	411	4	42(1	42(1	NOUN
admet-2774	411	5	)	)	PUNCT
admet-2774	411	6	(	(	PUNCT
admet-2774	411	7	2024	2024	NUM
admet-2774	411	8	)	)	PUNCT
admet-2774	411	9	1	1	NUM
admet-2774	411	10	-	-	SYM
admet-2774	411	11	13	13	NUM
admet-2774	411	12	.	.	PUNCT
admet-2774	411	13	https://doi.org/10.1080/02652048.2024.2427294	https://doi.org/10.1080/02652048.2024.2427294	NOUN
admet-2774	412	1	[	[	X
admet-2774	412	2	40	40	NUM
admet-2774	412	3	]	]	PUNCT
admet-2774	412	4	k.	k.	PROPN
admet-2774	412	5	jadhav	jadhav	PROPN
admet-2774	412	6	,	,	PUNCT
admet-2774	412	7	a.	a.	PROPN
admet-2774	412	8	jhilta	jhilta	PROPN
admet-2774	412	9	,	,	PUNCT
admet-2774	412	10	r.	r.	PROPN
admet-2774	412	11	singh	singh	PROPN
admet-2774	412	12	,	,	PUNCT
admet-2774	412	13	e.	e.	PROPN
admet-2774	412	14	ray	ray	PROPN
admet-2774	412	15	,	,	PUNCT
admet-2774	412	16	n.	n.	PROPN
admet-2774	412	17	sharma	sharma	PROPN
admet-2774	412	18	,	,	PUNCT
admet-2774	412	19	r.	r.	PROPN
admet-2774	412	20	shukla	shukla	PROPN
admet-2774	412	21	,	,	PUNCT
admet-2774	412	22	a.k	a.k	PROPN
admet-2774	412	23	.	.	PROPN
admet-2774	412	24	singh	singh	PROPN
admet-2774	412	25	,	,	PUNCT
admet-2774	412	26	r.k	r.k	PROPN
admet-2774	412	27	.	.	PROPN
admet-2774	412	28	verma	verma	PROPN
admet-2774	412	29	.	.	PUNCT
admet-2774	413	1	clofazimine	clofazimine	PROPN
admet-2774	413	2	nanoclusters	nanocluster	NOUN
admet-2774	413	3	show	show	VERB
admet-2774	413	4	high	high	ADJ
admet-2774	413	5	efficacy	efficacy	NOUN
admet-2774	413	6	in	in	ADP
admet-2774	413	7	experimental	experimental	ADJ
admet-2774	413	8	tb	tb	NOUN
admet-2774	413	9	with	with	ADP
admet-2774	413	10	amelioration	amelioration	NOUN
admet-2774	413	11	in	in	ADP
admet-2774	413	12	paradoxical	paradoxical	ADJ
admet-2774	413	13	lung	lung	NOUN
admet-2774	413	14	inflammation	inflammation	NOUN
admet-2774	413	15	.	.	PUNCT
admet-2774	414	1	biomaterials	biomaterial	NOUN
admet-2774	414	2	advances	advance	VERB
admet-2774	414	3	154	154	NUM
admet-2774	414	4	(	(	PUNCT
admet-2774	414	5	2023	2023	NUM
admet-2774	414	6	)	)	PUNCT
admet-2774	414	7	213594	213594	NUM
admet-2774	414	8	.	.	PUNCT
admet-2774	415	1	https://doi.org/10.1016/j.bioadv.2023.213594	https://doi.org/10.1016/j.bioadv.2023.213594	PROPN
admet-2774	416	1	[	[	X
admet-2774	416	2	41	41	NUM
admet-2774	416	3	]	]	X
admet-2774	416	4	y.	y.	PROPN
admet-2774	416	5	jiang	jiang	PROPN
admet-2774	416	6	,	,	PUNCT
admet-2774	416	7	y.	y.	PROPN
admet-2774	416	8	zhou	zhou	PROPN
admet-2774	416	9	,	,	PUNCT
admet-2774	416	10	c.y	c.y	PROPN
admet-2774	416	11	.	.	PROPN
admet-2774	416	12	zhang	zhang	PROPN
admet-2774	416	13	,	,	PUNCT
admet-2774	416	14	t.	t.	PROPN
admet-2774	416	15	fang	fang	X
admet-2774	416	16	.	.	PUNCT
admet-2774	417	1	co	co	NOUN
admet-2774	418	1	-	-	NOUN
admet-2774	419	1	delivery	delivery	NOUN
admet-2774	419	2	of	of	ADP
admet-2774	419	3	paclitaxel	paclitaxel	PROPN
admet-2774	419	4	and	and	CCONJ
admet-2774	419	5	doxorubicin	doxorubicin	VERB
admet-2774	419	6	by	by	ADP
admet-2774	419	7	ph	ph	ADJ
admet-2774	419	8	-	-	PUNCT
admet-2774	419	9	responsive	responsive	ADJ
admet-2774	419	10	prodrug	prodrug	NOUN
admet-2774	419	11	micelles	micelle	NOUN
admet-2774	419	12	for	for	ADP
admet-2774	419	13	cancer	cancer	NOUN
admet-2774	419	14	therapy	therapy	NOUN
admet-2774	419	15	.	.	PUNCT
admet-2774	420	1	international	international	ADJ
admet-2774	420	2	journal	journal	PROPN
admet-2774	420	3	of	of	ADP
admet-2774	420	4	nanomedicine	nanomedicine	NOUN
admet-2774	420	5	15	15	NUM
admet-2774	420	6	(	(	PUNCT
admet-2774	420	7	2020	2020	NUM
admet-2774	420	8	)	)	PUNCT
admet-2774	420	9	3319	3319	NUM
admet-2774	420	10	-	-	SYM
admet-2774	420	11	3331	3331	NUM
admet-2774	420	12	.	.	PUNCT
admet-2774	421	1	https://doi.org/10.2147/ijn.s249144	https://doi.org/10.2147/ijn.s249144	X
admet-2774	422	1	[	[	X
admet-2774	422	2	42	42	NUM
admet-2774	422	3	]	]	X
admet-2774	422	4	u.	u.	PROPN
admet-2774	422	5	verma	verma	PROPN
admet-2774	422	6	,	,	PUNCT
admet-2774	422	7	a.	a.	PROPN
admet-2774	422	8	mujumdar	mujumdar	PROPN
admet-2774	422	9	,	,	PUNCT
admet-2774	422	10	j.	j.	PROPN
admet-2774	422	11	naik	naik	PROPN
admet-2774	422	12	.	.	PUNCT
admet-2774	422	13	preparation	preparation	NOUN
admet-2774	422	14	of	of	ADP
admet-2774	422	15	efavirenz	efavirenz	NOUN
admet-2774	422	16	resinate	resinate	NOUN
admet-2774	422	17	by	by	ADP
admet-2774	422	18	spray	spray	NOUN
admet-2774	422	19	drying	dry	VERB
admet-2774	422	20	using	use	VERB
admet-2774	422	21	response	response	NOUN
admet-2774	422	22	surface	surface	NOUN
admet-2774	422	23	methodology	methodology	NOUN
admet-2774	422	24	and	and	CCONJ
admet-2774	422	25	its	its	PRON
admet-2774	422	26	physicochemical	physicochemical	ADJ
admet-2774	422	27	characterization	characterization	NOUN
admet-2774	422	28	for	for	ADP
admet-2774	422	29	taste	taste	NOUN
admet-2774	422	30	masking	mask	VERB
admet-2774	422	31	.	.	PUNCT
admet-2774	423	1	drying	dry	VERB
admet-2774	423	2	technology	technology	NOUN
admet-2774	423	3	38	38	NUM
admet-2774	423	4	(	(	PUNCT
admet-2774	423	5	2020	2020	NUM
admet-2774	423	6	)	)	PUNCT
admet-2774	423	7	793	793	NUM
admet-2774	423	8	-	-	SYM
admet-2774	423	9	805	805	NUM
admet-2774	423	10	.	.	PUNCT
admet-2774	424	1	https://doi.org/10.1080/07373937.2019.1590845	https://doi.org/10.1080/07373937.2019.1590845	PROPN
admet-2774	425	1	[	[	X
admet-2774	425	2	43	43	NUM
admet-2774	425	3	]	]	PUNCT
admet-2774	425	4	p.	p.	NOUN
admet-2774	425	5	wagh	wagh	PROPN
admet-2774	425	6	,	,	PUNCT
admet-2774	425	7	a.	a.	PROPN
admet-2774	425	8	mujumdar	mujumdar	PROPN
admet-2774	425	9	,	,	PUNCT
admet-2774	425	10	j.b	j.b	PROPN
admet-2774	425	11	.	.	PROPN
admet-2774	426	1	naik	naik	PROPN
admet-2774	426	2	.	.	PUNCT
admet-2774	427	1	preparation	preparation	NOUN
admet-2774	427	2	and	and	CCONJ
admet-2774	427	3	characterization	characterization	NOUN
admet-2774	427	4	of	of	ADP
admet-2774	427	5	ketorolac	ketorolac	PROPN
admet-2774	427	6	tromethamineloaded	tromethamineloade	VERB
admet-2774	427	7	ethyl	ethyl	PROPN
admet-2774	427	8	cellulose	cellulose	NOUN
admet-2774	427	9	micro-/nanospheres	micro-/nanosphere	NOUN
admet-2774	427	10	using	use	VERB
admet-2774	427	11	different	different	ADJ
admet-2774	427	12	techniques	technique	NOUN
admet-2774	427	13	.	.	PUNCT
admet-2774	428	1	particulate	particulate	NOUN
admet-2774	428	2	science	science	NOUN
admet-2774	428	3	and	and	CCONJ
admet-2774	428	4	technology	technology	NOUN
admet-2774	428	5	37	37	NUM
admet-2774	428	6	(	(	PUNCT
admet-2774	428	7	2019	2019	NUM
admet-2774	428	8	)	)	PUNCT
admet-2774	428	9	347	347	NUM
admet-2774	428	10	-	-	SYM
admet-2774	428	11	357	357	NUM
admet-2774	428	12	.	.	PUNCT
admet-2774	428	13	https://doi.org/10.1080/02726351.2017.1383330	https://doi.org/10.1080/02726351.2017.1383330	X
admet-2774	429	1	[	[	X
admet-2774	429	2	44	44	NUM
admet-2774	429	3	]	]	PUNCT
admet-2774	429	4	y.	y.	PROPN
admet-2774	429	5	zhang	zhang	PROPN
admet-2774	429	6	,	,	PUNCT
admet-2774	429	7	l.	l.	PROPN
admet-2774	429	8	tang	tang	PROPN
admet-2774	429	9	,	,	PUNCT
admet-2774	429	10	l.	l.	PROPN
admet-2774	429	11	sun	sun	PROPN
admet-2774	429	12	,	,	PUNCT
admet-2774	429	13	j.	j.	PROPN
admet-2774	429	14	bao	bao	PROPN
admet-2774	429	15	,	,	PUNCT
admet-2774	429	16	c.	c.	PROPN
admet-2774	429	17	song	song	PROPN
admet-2774	429	18	,	,	PUNCT
admet-2774	429	19	l.	l.	PROPN
admet-2774	429	20	huang	huang	PROPN
admet-2774	429	21	,	,	PUNCT
admet-2774	429	22	k.	k.	PROPN
admet-2774	429	23	liu	liu	PROPN
admet-2774	429	24	,	,	PUNCT
admet-2774	429	25	y.	y.	PROPN
admet-2774	429	26	tian	tian	PROPN
admet-2774	429	27	,	,	PUNCT
admet-2774	429	28	g.	g.	PROPN
admet-2774	429	29	tian	tian	PROPN
admet-2774	429	30	,	,	PUNCT
admet-2774	429	31	z.	z.	PROPN
admet-2774	429	32	li	li	PROPN
admet-2774	429	33	,	,	PUNCT
admet-2774	429	34	h.	h.	PROPN
admet-2774	429	35	sun	sun	PROPN
admet-2774	429	36	,	,	PUNCT
admet-2774	429	37	l.	l.	PROPN
admet-2774	429	38	mei	mei	PROPN
admet-2774	429	39	.	.	PUNCT
admet-2774	430	1	a	a	DET
admet-2774	430	2	novel	novel	ADJ
admet-2774	430	3	paclitaxel	paclitaxel	NOUN
admet-2774	430	4	-	-	PUNCT
admet-2774	430	5	loaded	load	VERB
admet-2774	430	6	poly(ε	poly(ε	NOUN
admet-2774	430	7	-	-	PUNCT
admet-2774	430	8	caprolactone)/poloxamer	caprolactone)/poloxamer	ADJ
admet-2774	430	9	188	188	NUM
admet-2774	430	10	blend	blend	NOUN
admet-2774	430	11	nanoparticle	nanoparticle	NOUN
admet-2774	430	12	overcoming	overcome	VERB
admet-2774	430	13	multidrug	multidrug	NOUN
admet-2774	430	14	resistance	resistance	NOUN
admet-2774	430	15	for	for	ADP
admet-2774	430	16	cancer	cancer	NOUN
admet-2774	430	17	treatment	treatment	NOUN
admet-2774	430	18	.	.	PUNCT
admet-2774	431	1	acta	acta	PROPN
admet-2774	431	2	biomaterialia	biomaterialia	PROPN
admet-2774	431	3	6	6	NUM
admet-2774	431	4	(	(	PUNCT
admet-2774	431	5	2010	2010	NUM
admet-2774	431	6	)	)	PUNCT
admet-2774	431	7	2045	2045	NUM
admet-2774	431	8	-	-	SYM
admet-2774	431	9	2052	2052	NUM
admet-2774	431	10	.	.	PUNCT
admet-2774	432	1	https://doi.org/10.1016/j.actbio.2009.11.035	https://doi.org/10.1016/j.actbio.2009.11.035	NOUN
admet-2774	433	1	[	[	X
admet-2774	433	2	45	45	NUM
admet-2774	433	3	]	]	SYM
admet-2774	433	4	s.y	s.y	PROPN
admet-2774	433	5	.	.	PROPN
admet-2774	433	6	lipaikin	lipaikin	PROPN
admet-2774	433	7	,	,	PUNCT
admet-2774	433	8	a.s	a.s	PROPN
admet-2774	433	9	.	.	PROPN
admet-2774	433	10	dorokhin	dorokhin	PROPN
admet-2774	433	11	,	,	PUNCT
admet-2774	433	12	g.a	g.a	PROPN
admet-2774	433	13	.	.	PROPN
admet-2774	433	14	ryltseva	ryltseva	PROPN
admet-2774	433	15	,	,	PUNCT
admet-2774	433	16	a.	a.	PROPN
admet-2774	433	17	v.	v.	PROPN
admet-2774	433	18	oberenko	oberenko	PROPN
admet-2774	433	19	,	,	PUNCT
admet-2774	433	20	a.	a.	PROPN
admet-2774	433	21	v.	v.	NOUN
admet-2774	433	22	shabanov	shabanov	PROPN
admet-2774	433	23	,	,	PUNCT
admet-2774	433	24	t.g	t.g	PROPN
admet-2774	433	25	.	.	PROPN
admet-2774	433	26	volova	volova	PROPN
admet-2774	433	27	,	,	PUNCT
admet-2774	433	28	e.i	e.i	PROPN
admet-2774	433	29	.	.	PROPN
admet-2774	433	30	shishatskaya	shishatskaya	PROPN
admet-2774	433	31	.	.	PUNCT
admet-2774	434	1	investigation	investigation	NOUN
admet-2774	434	2	of	of	ADP
admet-2774	434	3	drug	drug	NOUN
admet-2774	434	4	release	release	NOUN
admet-2774	434	5	kinetics	kinetic	NOUN
admet-2774	434	6	from	from	ADP
admet-2774	434	7	biodegradable	biodegradable	ADJ
admet-2774	434	8	polyhydroxyalkanoate	polyhydroxyalkanoate	ADJ
admet-2774	434	9	microparticles	microparticle	NOUN
admet-2774	434	10	.	.	PUNCT
admet-2774	435	1	reaction	reaction	NOUN
admet-2774	435	2	kinetics	kinetic	NOUN
admet-2774	435	3	,	,	PUNCT
admet-2774	435	4	mechanisms	mechanism	NOUN
admet-2774	435	5	and	and	CCONJ
admet-2774	435	6	catalysis	catalysis	NOUN
admet-2774	435	7	(	(	PUNCT
admet-2774	435	8	2025	2025	NUM
admet-2774	435	9	)	)	PUNCT
admet-2774	435	10	.	.	PUNCT
admet-2774	436	1	https://doi.org/10.1007/s11144-025-02852-w	https://doi.org/10.1007/s11144-025-02852-w	PROPN
admet-2774	437	1	[	[	X
admet-2774	437	2	46	46	NUM
admet-2774	437	3	]	]	X
admet-2774	437	4	j.m	j.m	PROPN
admet-2774	437	5	.	.	PROPN
admet-2774	437	6	da	da	PROPN
admet-2774	437	7	s.	s.	PROPN
admet-2774	437	8	leite	leite	PROPN
admet-2774	437	9	,	,	PUNCT
admet-2774	437	10	l.m	l.m	PROPN
admet-2774	437	11	.	.	PROPN
admet-2774	437	12	de	de	PROPN
admet-2774	437	13	santana	santana	PROPN
admet-2774	437	14	,	,	PUNCT
admet-2774	437	15	d.	d.	PROPN
admet-2774	437	16	nadvorny	nadvorny	PROPN
admet-2774	437	17	,	,	PUNCT
admet-2774	437	18	b.o	b.o	PROPN
admet-2774	437	19	.	.	PROPN
admet-2774	437	20	de	de	PROPN
admet-2774	437	21	abreu	abreu	PROPN
admet-2774	437	22	,	,	PUNCT
admet-2774	437	23	j.	j.	PROPN
admet-2774	437	24	de	de	PROPN
admet-2774	437	25	s.	s.	PROPN
admet-2774	437	26	rebouças	rebouças	PROPN
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admet-2774	437	41	soares	soares	PROPN
admet-2774	437	42	-	-	PUNCT
admet-2774	437	43	sobrinho	sobrinho	NOUN
admet-2774	437	44	.	.	PUNCT
admet-2774	438	1	nanoparticle	nanoparticle	NOUN
admet-2774	438	2	design	design	NOUN
admet-2774	438	3	for	for	ADP
admet-2774	438	4	hydrophilic	hydrophilic	ADJ
admet-2774	438	5	drugs	drug	NOUN
admet-2774	438	6	:	:	PUNCT
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admet-2774	438	8	biopolymeric	biopolymeric	ADJ
admet-2774	438	9	nanostructure	nanostructure	NOUN
admet-2774	438	10	.	.	PUNCT
admet-2774	439	1	journal	journal	NOUN
admet-2774	439	2	of	of	ADP
admet-2774	439	3	drug	drug	NOUN
admet-2774	439	4	delivery	delivery	NOUN
admet-2774	439	5	science	science	NOUN
admet-2774	439	6	and	and	CCONJ
admet-2774	439	7	technology	technology	NOUN
admet-2774	439	8	87	87	NUM
admet-2774	439	9	(	(	PUNCT
admet-2774	439	10	2023	2023	NUM
admet-2774	439	11	)	)	PUNCT
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admet-2774	439	16	]	]	PUNCT
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admet-2774	439	19	.	.	PUNCT
admet-2774	440	1	preparation	preparation	NOUN
admet-2774	440	2	and	and	CCONJ
admet-2774	440	3	characterisation	characterisation	NOUN
admet-2774	440	4	of	of	ADP
admet-2774	440	5	polycaprolactone	polycaprolactone	NOUN
admet-2774	440	6	-	-	PUNCT
admet-2774	440	7	fibroin	fibroin	NOUN
admet-2774	440	8	nanofibrous	nanofibrous	ADJ
admet-2774	440	9	scaffolds	scaffold	NOUN
admet-2774	440	10	containing	contain	VERB
admet-2774	440	11	allicin	allicin	NOUN
admet-2774	440	12	.	.	PUNCT
admet-2774	441	1	iet	iet	PROPN
admet-2774	441	2	nanobiotechnology	nanobiotechnology	PROPN
admet-2774	441	3	16	16	NUM
admet-2774	441	4	(	(	PUNCT
admet-2774	441	5	2022	2022	NUM
admet-2774	441	6	)	)	PUNCT
admet-2774	441	7	239	239	NUM
admet-2774	441	8	-	-	SYM
admet-2774	441	9	249	249	NUM
admet-2774	441	10	.	.	PUNCT
admet-2774	442	1	https://doi.org/10.1049/nbt2.12092	https://doi.org/10.1049/nbt2.12092	VERB
admet-2774	443	1	https://doi.org/10.5599/admet.2774	https://doi.org/10.5599/admet.2774	NOUN
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admet-2774	443	3	https://doi.org/10.5599/admet.1998	https://doi.org/10.5599/admet.1998	PRON
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admet-2774	443	5	https://doi.org/10.1080/07373937.2023.2298778	https://doi.org/10.1080/07373937.2023.2298778	VERB
admet-2774	443	6	https://doi.org/10.5599/admet.1740	https://doi.org/10.5599/admet.1740	NOUN
admet-2774	443	7	https://doi.org/10.1080/07373937.2023.2251572	https://doi.org/10.1080/07373937.2023.2251572	ADJ
admet-2774	443	8	https://doi.org/10.1080/02652048.2024.2427294	https://doi.org/10.1080/02652048.2024.2427294	PUNCT
admet-2774	444	1	https://doi.org/10.1016/j.bioadv.2023.213594	https://doi.org/10.1016/j.bioadv.2023.213594	VERB
admet-2774	444	2	https://doi.org/10.2147/ijn.s249144	https://doi.org/10.2147/ijn.s249144	X
admet-2774	444	3	https://doi.org/10.1080/07373937.2019.1590845	https://doi.org/10.1080/07373937.2019.1590845	PROPN
admet-2774	444	4	https://doi.org/10.1080/02726351.2017.1383330	https://doi.org/10.1080/02726351.2017.1383330	PROPN
admet-2774	444	5	https://doi.org/10.1016/j.actbio.2009.11.035	https://doi.org/10.1016/j.actbio.2009.11.035	PROPN
admet-2774	444	6	https://doi.org/10.1007/s11144-025-02852-w	https://doi.org/10.1007/s11144-025-02852-w	PROPN
admet-2774	444	7	https://doi.org/10.1016/j.jddst.2023.104754	https://doi.org/10.1016/j.jddst.2023.104754	NOUN
admet-2774	444	8	https://doi.org/10.1049/nbt2.12092	https://doi.org/10.1049/nbt2.12092	VERB
admet-2774	444	9	e.	e.	PROPN
admet-2774	444	10	kole	kole	PROPN
admet-2774	444	11	et	et	PROPN
admet-2774	444	12	al	al	PROPN
admet-2774	444	13	.	.	PROPN
admet-2774	444	14	admet	admet	PROPN
admet-2774	444	15	&	&	CCONJ
admet-2774	444	16	dmpk	dmpk	PROPN
admet-2774	444	17	13(4	13(4	NUM
admet-2774	444	18	)	)	PUNCT
admet-2774	444	19	(	(	PUNCT
admet-2774	444	20	2025	2025	NUM
admet-2774	444	21	)	)	PUNCT
admet-2774	444	22	2774	2774	NUM
admet-2774	444	23	18	18	NUM
admet-2774	445	1	[	[	X
admet-2774	445	2	48	48	NUM
admet-2774	445	3	]	]	PUNCT
admet-2774	445	4	x.	x.	NOUN
admet-2774	445	5	lin	lin	PROPN
admet-2774	445	6	,	,	PUNCT
admet-2774	445	7	y.	y.	PROPN
admet-2774	445	8	shi	shi	PROPN
admet-2774	445	9	,	,	PUNCT
admet-2774	445	10	s.	s.	PROPN
admet-2774	445	11	yu	yu	PROPN
admet-2774	445	12	,	,	PUNCT
admet-2774	445	13	s.	s.	PROPN
admet-2774	445	14	li	li	PROPN
admet-2774	445	15	,	,	PUNCT
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admet-2774	445	17	li	li	PROPN
admet-2774	445	18	,	,	PUNCT
admet-2774	445	19	m.	m.	PROPN
admet-2774	445	20	li	li	PROPN
admet-2774	445	21	,	,	PUNCT
admet-2774	445	22	s.	s.	PROPN
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admet-2774	445	24	,	,	PUNCT
admet-2774	445	25	y.	y.	PROPN
admet-2774	445	26	wang	wang	PROPN
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admet-2774	445	30	.	.	PUNCT
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admet-2774	446	4	-	-	PUNCT
admet-2774	446	5	b	b	PROPN
admet-2774	446	6	-	-	PUNCT
admet-2774	446	7	pcl	pcl	PROPN
admet-2774	446	8	and	and	CCONJ
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admet-2774	446	10	on	on	ADP
admet-2774	446	11	in	in	ADP
admet-2774	446	12	vitro	vitro	X
admet-2774	446	13	radioprotection	radioprotection	NOUN
admet-2774	446	14	activity	activity	NOUN
admet-2774	446	15	of	of	ADP
admet-2774	446	16	curcumin	curcumin	NOUN
admet-2774	446	17	-	-	PUNCT
admet-2774	446	18	loaded	load	VERB
admet-2774	446	19	nanoparticles	nanoparticle	NOUN
admet-2774	446	20	.	.	PUNCT
admet-2774	447	1	frontiers	frontier	NOUN
admet-2774	447	2	in	in	ADP
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admet-2774	447	4	8	8	NUM
admet-2774	447	5	(	(	PUNCT
admet-2774	447	6	2020	2020	NUM
admet-2774	447	7	)	)	PUNCT
admet-2774	447	8	212	212	NUM
admet-2774	447	9	.	.	PUNCT
admet-2774	448	1	https://doi.org/10.3389/fchem.2020.00212	https://doi.org/10.3389/fchem.2020.00212	PROPN
admet-2774	448	2	[	[	X
admet-2774	448	3	49	49	NUM
admet-2774	448	4	]	]	PUNCT
admet-2774	448	5	t.	t.	PROPN
admet-2774	448	6	khuroo	khuroo	PROPN
admet-2774	448	7	,	,	PUNCT
admet-2774	448	8	e.m	e.m	PROPN
admet-2774	448	9	.	.	PROPN
admet-2774	448	10	mohamed	mohamed	PROPN
admet-2774	448	11	,	,	PUNCT
admet-2774	448	12	s.	s.	PROPN
admet-2774	448	13	dharani	dharani	PROPN
admet-2774	448	14	,	,	PUNCT
admet-2774	448	15	c.	c.	PROPN
admet-2774	448	16	kayalar	kayalar	PROPN
admet-2774	448	17	,	,	PUNCT
admet-2774	448	18	t.	t.	PROPN
admet-2774	448	19	ozkan	ozkan	PROPN
admet-2774	448	20	,	,	PUNCT
admet-2774	448	21	m.a	m.a	PROPN
admet-2774	448	22	.	.	PROPN
admet-2774	448	23	kuttolamadom	kuttolamadom	PROPN
admet-2774	448	24	,	,	PUNCT
admet-2774	448	25	z.	z.	PROPN
admet-2774	448	26	rahman	rahman	PROPN
admet-2774	448	27	,	,	PUNCT
admet-2774	448	28	m.a	m.a	PROPN
admet-2774	448	29	.	.	PROPN
admet-2774	448	30	khan	khan	PROPN
admet-2774	448	31	.	.	PUNCT
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admet-2774	449	2	-	-	PUNCT
admet-2774	449	3	rapidly	rapidly	ADV
admet-2774	449	4	dissolving	dissolve	VERB
admet-2774	449	5	printlets	printlet	NOUN
admet-2774	449	6	of	of	ADP
admet-2774	449	7	isoniazid	isoniazid	NOUN
admet-2774	449	8	manufactured	manufacture	VERB
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admet-2774	449	10	sls	sls	PROPN
admet-2774	449	11	3d	3d	PROPN
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admet-2774	449	13	:	:	PUNCT
admet-2774	449	14	in	in	ADP
admet-2774	449	15	vitro	vitro	X
admet-2774	449	16	and	and	CCONJ
admet-2774	449	17	in	in	ADP
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admet-2774	449	19	characterization	characterization	NOUN
admet-2774	449	20	.	.	PUNCT
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admet-2774	450	3	19	19	NUM
admet-2774	450	4	(	(	PUNCT
admet-2774	450	5	2022	2022	NUM
admet-2774	450	6	)	)	PUNCT
admet-2774	450	7	2937	2937	NUM
admet-2774	450	8	-	-	SYM
admet-2774	450	9	2949	2949	NUM
admet-2774	450	10	.	.	PUNCT
admet-2774	451	1	https://doi.org/10.1021/acs.molpharmaceut.2c00306	https://doi.org/10.1021/acs.molpharmaceut.2c00306	NOUN
admet-2774	452	1	©	©	PROPN
admet-2774	452	2	2025	2025	NUM
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admet-2774	452	12	croatia	croatia	PROPN
admet-2774	452	13	.	.	PUNCT
admet-2774	453	1	this	this	DET
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admet-2774	453	5	open	open	ADJ
admet-2774	453	6	-	-	PUNCT
admet-2774	453	7	access	access	NOUN
admet-2774	453	8	article	article	NOUN
admet-2774	453	9	distributed	distribute	VERB
admet-2774	453	10	under	under	ADP
admet-2774	453	11	the	the	DET
admet-2774	453	12	terms	term	NOUN
admet-2774	453	13	and	and	CCONJ
admet-2774	453	14	conditions	condition	NOUN
admet-2774	453	15	of	of	ADP
admet-2774	453	16	the	the	DET
admet-2774	453	17	creative	creative	ADJ
admet-2774	453	18	commons	common	NOUN
admet-2774	453	19	attribution	attribution	NOUN
admet-2774	453	20	license	license	NOUN
admet-2774	453	21	(	(	PUNCT
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admet-2774	453	23	)	)	PUNCT
admet-2774	454	1	https://doi.org/10.3389/fchem.2020.00212	https://doi.org/10.3389/fchem.2020.00212	PROPN
admet-2774	454	2	https://doi.org/10.1021/acs.molpharmaceut.2c00306	https://doi.org/10.1021/acs.molpharmaceut.2c00306	NUM
admet-2774	454	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN