id	sid	tid	token	lemma	pos
admet-280	1	1	manuscript	manuscript	PROPN
admet-280	1	2	doi	doi	PROPN
admet-280	1	3	:	:	PUNCT
admet-280	1	4	10.5599	10.5599	NUM
admet-280	1	5	/	/	SYM
admet-280	1	6	admet.4.2.280	admet.4.2.280	NUM
admet-280	1	7	62	62	NUM
admet-280	1	8	admet	admet	NOUN
admet-280	1	9	&	&	CCONJ
admet-280	1	10	dmpk	dmpk	PROPN
admet-280	1	11	4(2	4(2	NUM
admet-280	1	12	)	)	PUNCT
admet-280	1	13	(	(	PUNCT
admet-280	1	14	2016	2016	NUM
admet-280	1	15	)	)	PUNCT
admet-280	1	16	62	62	NUM
admet-280	1	17	-	-	SYM
admet-280	1	18	83	83	NUM
admet-280	1	19	;	;	PUNCT
admet-280	1	20	doi	doi	NOUN
admet-280	1	21	:	:	PUNCT
admet-280	1	22	10.5599	10.5599	NUM
admet-280	1	23	/	/	SYM
admet-280	1	24	admet.4.2.280	admet.4.2.280	VERB
admet-280	1	25	open	open	ADJ
admet-280	1	26	access	access	NOUN
admet-280	1	27	:	:	PUNCT
admet-280	1	28	issn	issn	PROPN
admet-280	1	29	:	:	PUNCT
admet-280	1	30	1848	1848	NUM
admet-280	1	31	-	-	SYM
admet-280	1	32	7718	7718	NUM
admet-280	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-280	1	34	original	original	ADJ
admet-280	1	35	scientific	scientific	ADJ
admet-280	1	36	paper	paper	NOUN
admet-280	1	37	pharmacogenetic	pharmacogenetic	ADJ
admet-280	1	38	profiling	profiling	NOUN
admet-280	1	39	and	and	CCONJ
admet-280	1	40	metabolic	metabolic	NOUN
admet-280	1	41	activity	activity	NOUN
admet-280	1	42	of	of	ADP
admet-280	1	43	human	human	ADJ
admet-280	1	44	embryonic	embryonic	ADJ
admet-280	1	45	stem	stem	NOUN
admet-280	1	46	cell	cell	NOUN
admet-280	1	47	derived	derive	VERB
admet-280	1	48	hepatocytes	hepatocyte	NOUN
admet-280	1	49	:	:	PUNCT
admet-280	1	50	focus	focus	VERB
admet-280	1	51	on	on	ADP
admet-280	1	52	cyp450mediated	cyp450mediate	VERB
admet-280	1	53	oxidation	oxidation	NOUN
admet-280	1	54	jenna	jenna	PROPN
admet-280	1	55	l.	l.	PROPN
admet-280	1	56	voellinger	voellinger	PROPN
admet-280	1	57	and	and	CCONJ
admet-280	1	58	edward	edward	PROPN
admet-280	1	59	j.	j.	PROPN
admet-280	1	60	kelly	kelly	PROPN
admet-280	1	61	department	department	PROPN
admet-280	1	62	of	of	ADP
admet-280	1	63	pharmaceutics	pharmaceutic	NOUN
admet-280	1	64	,	,	PUNCT
admet-280	1	65	university	university	PROPN
admet-280	1	66	of	of	ADP
admet-280	1	67	washington	washington	PROPN
admet-280	1	68	,	,	PUNCT
admet-280	1	69	seattle	seattle	PROPN
admet-280	1	70	,	,	PUNCT
admet-280	1	71	wa	wa	PROPN
admet-280	1	72	98195	98195	NUM
admet-280	1	73	.	.	PUNCT
admet-280	2	1	e	e	X
admet-280	2	2	-	-	NOUN
admet-280	2	3	mail	mail	NOUN
admet-280	2	4	addresses	address	NOUN
admet-280	2	5	:	:	PUNCT
admet-280	2	6	jenna	jenna	PROPN
admet-280	2	7	l.	l.	PROPN
admet-280	2	8	voellinger	voellinger	PROPN
admet-280	2	9	,	,	PUNCT
admet-280	2	10	jennav2@uw.edu	jennav2@uw.edu	PROPN
admet-280	2	11	;	;	PUNCT
admet-280	2	12	edward	edward	PROPN
admet-280	2	13	j.	j.	PROPN
admet-280	2	14	kelly	kelly	PROPN
admet-280	2	15	,	,	PUNCT
admet-280	2	16	edkelly@uw.edu	edkelly@uw.edu	PROPN
admet-280	2	17	.	.	PROPN
admet-280	2	18	received	receive	VERB
admet-280	2	19	:	:	PUNCT
admet-280	2	20	march	march	PROPN
admet-280	2	21	25	25	NUM
admet-280	2	22	,	,	PUNCT
admet-280	2	23	2016	2016	NUM
admet-280	2	24	;	;	PUNCT
admet-280	2	25	revised	revise	VERB
admet-280	2	26	:	:	PUNCT
admet-280	2	27	may	may	AUX
admet-280	2	28	14	14	NUM
admet-280	2	29	,	,	PUNCT
admet-280	2	30	2016	2016	NUM
admet-280	2	31	;	;	PUNCT
admet-280	2	32	published	publish	VERB
admet-280	2	33	:	:	PUNCT
admet-280	2	34	june	june	PROPN
admet-280	2	35	29	29	NUM
admet-280	2	36	,	,	PUNCT
admet-280	2	37	2016	2016	NUM
admet-280	2	38	abstract	abstract	ADJ
admet-280	2	39	primary	primary	ADJ
admet-280	2	40	human	human	ADJ
admet-280	2	41	hepatocytes	hepatocyte	NOUN
admet-280	2	42	are	be	AUX
admet-280	2	43	commonly	commonly	ADV
admet-280	2	44	used	use	VERB
admet-280	2	45	to	to	PART
admet-280	2	46	evaluate	evaluate	VERB
admet-280	2	47	liver	liver	NOUN
admet-280	2	48	drug	drug	NOUN
admet-280	2	49	metabolism	metabolism	NOUN
admet-280	2	50	and	and	CCONJ
admet-280	2	51	toxicity	toxicity	NOUN
admet-280	2	52	.	.	PUNCT
admet-280	3	1	pluripotent	pluripotent	ADJ
admet-280	3	2	stem	stem	NOUN
admet-280	3	3	cell	cell	NOUN
admet-280	3	4	derived	derive	VERB
admet-280	3	5	hepatocytes	hepatocyte	NOUN
admet-280	3	6	(	(	PUNCT
admet-280	3	7	scdhs	scdhs	NOUN
admet-280	3	8	)	)	PUNCT
admet-280	3	9	have	have	VERB
admet-280	3	10	the	the	DET
admet-280	3	11	potential	potential	NOUN
admet-280	3	12	to	to	PART
admet-280	3	13	overcome	overcome	VERB
admet-280	3	14	access	access	NOUN
admet-280	3	15	and	and	CCONJ
admet-280	3	16	function	function	NOUN
admet-280	3	17	-	-	PUNCT
admet-280	3	18	related	relate	VERB
admet-280	3	19	limitations	limitation	NOUN
admet-280	3	20	associated	associate	VERB
admet-280	3	21	with	with	ADP
admet-280	3	22	primary	primary	ADJ
admet-280	3	23	hepatocytes	hepatocyte	NOUN
admet-280	3	24	.	.	PUNCT
admet-280	4	1	scdhs	scdhs	PROPN
admet-280	4	2	may	may	AUX
admet-280	4	3	also	also	ADV
admet-280	4	4	provide	provide	VERB
admet-280	4	5	an	an	DET
admet-280	4	6	improved	improved	ADJ
admet-280	4	7	system	system	NOUN
admet-280	4	8	for	for	ADP
admet-280	4	9	evaluating	evaluate	VERB
admet-280	4	10	genotypephenotype	genotypephenotype	NOUN
admet-280	4	11	relationships	relationship	NOUN
admet-280	4	12	,	,	PUNCT
admet-280	4	13	e.g.	e.g.	ADV
admet-280	4	14	cytochrome	cytochrome	NOUN
admet-280	4	15	p450	p450	PROPN
admet-280	4	16	(	(	PUNCT
admet-280	4	17	cyp	cyp	ADJ
admet-280	4	18	)	)	PUNCT
admet-280	4	19	gene	gene	NOUN
admet-280	4	20	polymorphisms	polymorphism	NOUN
admet-280	4	21	and	and	CCONJ
admet-280	4	22	their	their	PRON
admet-280	4	23	impact	impact	NOUN
admet-280	4	24	on	on	ADP
admet-280	4	25	drug	drug	NOUN
admet-280	4	26	metabolism	metabolism	NOUN
admet-280	4	27	and	and	CCONJ
admet-280	4	28	toxicity	toxicity	NOUN
admet-280	4	29	.	.	PUNCT
admet-280	5	1	however	however	ADV
admet-280	5	2	,	,	PUNCT
admet-280	5	3	in	in	ADP
admet-280	5	4	order	order	NOUN
admet-280	5	5	for	for	ADP
admet-280	5	6	scdhs	scdhs	ADJ
admet-280	5	7	to	to	PART
admet-280	5	8	become	become	VERB
admet-280	5	9	routinely	routinely	ADV
admet-280	5	10	used	use	VERB
admet-280	5	11	in	in	ADP
admet-280	5	12	preclinical	preclinical	ADJ
admet-280	5	13	drug	drug	NOUN
admet-280	5	14	metabolism	metabolism	NOUN
admet-280	5	15	and	and	CCONJ
admet-280	5	16	toxicity	toxicity	NOUN
admet-280	5	17	screening	screening	NOUN
admet-280	5	18	,	,	PUNCT
admet-280	5	19	they	they	PRON
admet-280	5	20	must	must	AUX
admet-280	5	21	demonstrate	demonstrate	VERB
admet-280	5	22	reproducible	reproducible	ADJ
admet-280	5	23	activity	activity	NOUN
admet-280	5	24	of	of	ADP
admet-280	5	25	drug	drug	NOUN
admet-280	5	26	metabolism	metabolism	NOUN
admet-280	5	27	proteins	protein	NOUN
admet-280	5	28	,	,	PUNCT
admet-280	5	29	particularly	particularly	ADV
admet-280	5	30	the	the	DET
admet-280	5	31	oxidative	oxidative	ADJ
admet-280	5	32	cyp	cyp	ADJ
admet-280	5	33	enzymes	enzyme	NOUN
admet-280	5	34	.	.	PUNCT
admet-280	6	1	we	we	PRON
admet-280	6	2	characterized	characterize	VERB
admet-280	6	3	the	the	DET
admet-280	6	4	differentiation	differentiation	NOUN
admet-280	6	5	status	status	NOUN
admet-280	6	6	of	of	ADP
admet-280	6	7	scdhs	scdhs	NOUN
admet-280	6	8	,	,	PUNCT
admet-280	6	9	with	with	ADP
admet-280	6	10	emphasis	emphasis	NOUN
admet-280	6	11	on	on	ADP
admet-280	6	12	the	the	DET
admet-280	6	13	expression	expression	NOUN
admet-280	6	14	and	and	CCONJ
admet-280	6	15	functional	functional	ADJ
admet-280	6	16	capacity	capacity	NOUN
admet-280	6	17	of	of	ADP
admet-280	6	18	drug	drug	NOUN
admet-280	6	19	-	-	PUNCT
admet-280	6	20	metabolizing	metabolize	VERB
admet-280	6	21	enzymes	enzyme	NOUN
admet-280	6	22	,	,	PUNCT
admet-280	6	23	and	and	CCONJ
admet-280	6	24	genetically	genetically	ADV
admet-280	6	25	profiled	profile	VERB
admet-280	6	26	the	the	DET
admet-280	6	27	commonly	commonly	ADV
admet-280	6	28	used	use	VERB
admet-280	6	29	wicell	wicell	PROPN
admet-280	6	30	®	®	NOUN
admet-280	6	31	hesc	hesc	NOUN
admet-280	6	32	lines	line	NOUN
admet-280	6	33	,	,	PUNCT
admet-280	6	34	focusing	focus	VERB
admet-280	6	35	on	on	ADP
admet-280	6	36	cyp2d6	cyp2d6	NOUN
admet-280	6	37	in	in	ADP
admet-280	6	38	our	our	PRON
admet-280	6	39	analysis	analysis	NOUN
admet-280	6	40	.	.	PUNCT
admet-280	7	1	an	an	DET
admet-280	7	2	assay	assay	NOUN
admet-280	7	3	of	of	ADP
admet-280	7	4	enzymatic	enzymatic	ADJ
admet-280	7	5	function	function	NOUN
admet-280	7	6	in	in	ADP
admet-280	7	7	scdhs	scdhs	NOUN
admet-280	7	8	using	use	VERB
admet-280	7	9	a	a	DET
admet-280	7	10	cyp	cyp	ADJ
admet-280	7	11	cocktail	cocktail	NOUN
admet-280	7	12	assay	assay	NOUN
admet-280	7	13	designed	design	VERB
admet-280	7	14	to	to	PART
admet-280	7	15	measure	measure	VERB
admet-280	7	16	8	8	NUM
admet-280	7	17	different	different	ADJ
admet-280	7	18	isozymes	isozyme	NOUN
admet-280	7	19	revealed	reveal	VERB
admet-280	7	20	only	only	ADV
admet-280	7	21	minimal	minimal	ADJ
admet-280	7	22	activity	activity	NOUN
admet-280	7	23	for	for	ADP
admet-280	7	24	cyp3a	cyp3a	NOUN
admet-280	7	25	,	,	PUNCT
admet-280	7	26	below	below	ADP
admet-280	7	27	that	that	PRON
admet-280	7	28	observed	observe	VERB
admet-280	7	29	in	in	ADP
admet-280	7	30	primary	primary	ADJ
admet-280	7	31	hepatocytes	hepatocyte	NOUN
admet-280	7	32	.	.	PUNCT
admet-280	8	1	with	with	ADP
admet-280	8	2	regard	regard	NOUN
admet-280	8	3	to	to	ADP
admet-280	8	4	cyp2d6	cyp2d6	NOUN
admet-280	8	5	gene	gene	NOUN
admet-280	8	6	copy	copy	NOUN
admet-280	8	7	number	number	NOUN
admet-280	8	8	variation	variation	NOUN
admet-280	8	9	,	,	PUNCT
admet-280	8	10	we	we	PRON
admet-280	8	11	found	find	VERB
admet-280	8	12	the	the	DET
admet-280	8	13	h1	h1	NOUN
admet-280	8	14	line	line	NOUN
admet-280	8	15	has	have	VERB
admet-280	8	16	only	only	ADV
admet-280	8	17	one	one	NUM
admet-280	8	18	gene	gene	NOUN
admet-280	8	19	copy	copy	NOUN
admet-280	8	20	,	,	PUNCT
admet-280	8	21	which	which	PRON
admet-280	8	22	also	also	ADV
admet-280	8	23	harbors	harbor	VERB
admet-280	8	24	the	the	DET
admet-280	8	25	cyp2d6	cyp2d6	PROPN
admet-280	8	26	*	*	SYM
admet-280	8	27	41	41	NUM
admet-280	8	28	splicing	splicing	NOUN
admet-280	8	29	defect	defect	NOUN
admet-280	8	30	,	,	PUNCT
admet-280	8	31	predictive	predictive	NOUN
admet-280	8	32	of	of	ADP
admet-280	8	33	a	a	DET
admet-280	8	34	cyp2d6	cyp2d6	NOUN
admet-280	8	35	poor	poor	ADJ
admet-280	8	36	/	/	SYM
admet-280	8	37	intermediate	intermediate	ADJ
admet-280	8	38	metabolizer	metabolizer	NOUN
admet-280	8	39	.	.	PUNCT
admet-280	9	1	we	we	PRON
admet-280	9	2	identified	identify	VERB
admet-280	9	3	no	no	DET
admet-280	9	4	cyp2d6	cyp2d6	NOUN
admet-280	9	5	gene	gene	NOUN
admet-280	9	6	duplications	duplication	NOUN
admet-280	9	7	,	,	PUNCT
admet-280	9	8	indicating	indicate	VERB
admet-280	9	9	no	no	DET
admet-280	9	10	representative	representative	ADJ
admet-280	9	11	ultra	ultra	ADJ
admet-280	9	12	-	-	ADJ
admet-280	9	13	rapid	rapid	ADJ
admet-280	9	14	metabolizer	metabolizer	NOUN
admet-280	9	15	.	.	PUNCT
admet-280	10	1	the	the	DET
admet-280	10	2	h7	h7	PROPN
admet-280	10	3	and	and	CCONJ
admet-280	10	4	h14	h14	NOUN
admet-280	10	5	lines	line	NOUN
admet-280	10	6	are	be	AUX
admet-280	10	7	heterozygous	heterozygous	ADJ
admet-280	10	8	for	for	ADP
admet-280	10	9	the	the	DET
admet-280	10	10	non	non	ADJ
admet-280	10	11	-	-	ADJ
admet-280	10	12	functional	functional	ADJ
admet-280	10	13	cyp2d6	cyp2d6	NOUN
admet-280	10	14	*	*	SYM
admet-280	10	15	4	4	NUM
admet-280	10	16	variant	variant	NOUN
admet-280	10	17	resulting	result	VERB
admet-280	10	18	in	in	ADP
admet-280	10	19	a	a	DET
admet-280	10	20	predicted	predict	VERB
admet-280	10	21	intermediate	intermediate	ADJ
admet-280	10	22	metabolizer	metabolizer	ADJ
admet-280	10	23	phenotype	phenotype	NOUN
admet-280	10	24	.	.	PUNCT
admet-280	11	1	in	in	ADP
admet-280	11	2	addition	addition	NOUN
admet-280	11	3	,	,	PUNCT
admet-280	11	4	we	we	PRON
admet-280	11	5	compared	compare	VERB
admet-280	11	6	the	the	DET
admet-280	11	7	penetrance	penetrance	NOUN
admet-280	11	8	of	of	ADP
admet-280	11	9	the	the	DET
admet-280	11	10	cyp2d6	cyp2d6	NOUN
admet-280	11	11	*	*	SYM
admet-280	11	12	41	41	NUM
admet-280	11	13	splicing	splicing	NOUN
admet-280	11	14	defect	defect	NOUN
admet-280	11	15	in	in	ADP
admet-280	11	16	scdhs	scdhs	ADJ
admet-280	11	17	and	and	CCONJ
admet-280	11	18	liver	liver	NOUN
admet-280	11	19	tissue	tissue	NOUN
admet-280	11	20	via	via	ADP
admet-280	11	21	reverse	reverse	NOUN
admet-280	11	22	-	-	PUNCT
admet-280	11	23	transcription	transcription	NOUN
admet-280	11	24	pcr	pcr	NOUN
admet-280	11	25	assay	assay	NOUN
admet-280	11	26	.	.	PUNCT
admet-280	12	1	we	we	PRON
admet-280	12	2	found	find	VERB
admet-280	12	3	incomplete	incomplete	ADJ
admet-280	12	4	penetrance	penetrance	NOUN
admet-280	12	5	of	of	ADP
admet-280	12	6	the	the	DET
admet-280	12	7	cyp2d6	cyp2d6	NOUN
admet-280	12	8	*	*	SYM
admet-280	12	9	41	41	NUM
admet-280	12	10	allele	allele	NOUN
admet-280	12	11	in	in	ADP
admet-280	12	12	liver	liver	NOUN
admet-280	12	13	tissue	tissue	NOUN
admet-280	12	14	and	and	CCONJ
admet-280	12	15	variable	variable	ADJ
admet-280	12	16	penetrance	penetrance	NOUN
admet-280	12	17	in	in	ADP
admet-280	12	18	scdhs	scdhs	PROPN
admet-280	12	19	.	.	PUNCT
admet-280	13	1	based	base	VERB
admet-280	13	2	on	on	ADP
admet-280	13	3	gene	gene	NOUN
admet-280	13	4	expression	expression	NOUN
admet-280	13	5	profiling	profiling	NOUN
admet-280	13	6	,	,	PUNCT
admet-280	13	7	scdhs	scdhs	VERB
admet-280	13	8	most	most	ADV
admet-280	13	9	closely	closely	ADV
admet-280	13	10	resemble	resemble	VERB
admet-280	13	11	fetal	fetal	ADJ
admet-280	13	12	hepatocytes	hepatocyte	NOUN
admet-280	13	13	,	,	PUNCT
admet-280	13	14	especially	especially	ADV
admet-280	13	15	with	with	ADP
admet-280	13	16	regards	regard	NOUN
admet-280	13	17	to	to	ADP
admet-280	13	18	afp	afp	PROPN
admet-280	13	19	,	,	PUNCT
admet-280	13	20	cyp3a7	cyp3a7	NOUN
admet-280	13	21	and	and	CCONJ
admet-280	13	22	fmo1	fmo1	NOUN
admet-280	13	23	expression	expression	NOUN
admet-280	13	24	.	.	PUNCT
admet-280	14	1	finally	finally	ADV
admet-280	14	2	,	,	PUNCT
admet-280	14	3	these	these	DET
admet-280	14	4	studies	study	NOUN
admet-280	14	5	indicate	indicate	VERB
admet-280	14	6	a	a	DET
admet-280	14	7	low	low	ADJ
admet-280	14	8	degree	degree	NOUN
admet-280	14	9	of	of	ADP
admet-280	14	10	genetic	genetic	ADJ
admet-280	14	11	diversity	diversity	NOUN
admet-280	14	12	of	of	ADP
admet-280	14	13	pharmacogenetically	pharmacogenetically	ADV
admet-280	14	14	-	-	PUNCT
admet-280	14	15	relevant	relevant	ADJ
admet-280	14	16	genes	gene	NOUN
admet-280	14	17	in	in	ADP
admet-280	14	18	the	the	DET
admet-280	14	19	wicell	wicell	PROPN
admet-280	14	20	®	®	PROPN
admet-280	14	21	hesc	hesc	NOUN
admet-280	14	22	lines	line	NOUN
admet-280	14	23	.	.	PUNCT
admet-280	15	1	keywords	keyword	VERB
admet-280	15	2	drug	drug	NOUN
admet-280	15	3	metabolism	metabolism	NOUN
admet-280	15	4	;	;	PUNCT
admet-280	15	5	adme	adme	PROPN
admet-280	15	6	;	;	PUNCT
admet-280	15	7	in	in	ADP
admet-280	15	8	vitro	vitro	X
admet-280	15	9	introduction	introduction	NOUN
admet-280	15	10	preclinical	preclinical	ADJ
admet-280	15	11	screening	screening	NOUN
admet-280	15	12	and	and	CCONJ
admet-280	15	13	characterization	characterization	NOUN
admet-280	15	14	of	of	ADP
admet-280	15	15	the	the	DET
admet-280	15	16	metabolic	metabolic	NOUN
admet-280	15	17	pathways	pathway	NOUN
admet-280	15	18	of	of	ADP
admet-280	15	19	a	a	DET
admet-280	15	20	new	new	ADJ
admet-280	15	21	drug	drug	NOUN
admet-280	15	22	is	be	AUX
admet-280	15	23	a	a	DET
admet-280	15	24	necessary	necessary	ADJ
admet-280	15	25	part	part	NOUN
admet-280	15	26	of	of	ADP
admet-280	15	27	its	its	PRON
admet-280	15	28	development	development	NOUN
admet-280	15	29	and	and	CCONJ
admet-280	15	30	can	can	AUX
admet-280	15	31	be	be	AUX
admet-280	15	32	used	use	VERB
admet-280	15	33	to	to	PART
admet-280	15	34	aid	aid	VERB
admet-280	15	35	in	in	ADP
admet-280	15	36	predicting	predict	VERB
admet-280	15	37	drug	drug	NOUN
admet-280	15	38	bioavailability	bioavailability	NOUN
admet-280	15	39	,	,	PUNCT
admet-280	15	40	drug	drug	NOUN
admet-280	15	41	efficacy	efficacy	NOUN
admet-280	15	42	,	,	PUNCT
admet-280	15	43	drug	drug	NOUN
admet-280	15	44	-	-	PUNCT
admet-280	15	45	drug	drug	NOUN
admet-280	15	46	interactions	interaction	NOUN
admet-280	15	47	,	,	PUNCT
admet-280	15	48	and	and	CCONJ
admet-280	15	49	drug	drug	NOUN
admet-280	15	50	toxicity	toxicity	NOUN
admet-280	15	51	.	.	PUNCT
admet-280	16	1	the	the	DET
admet-280	16	2	main	main	ADJ
admet-280	16	3	family	family	NOUN
admet-280	16	4	of	of	ADP
admet-280	16	5	enzymes	enzyme	NOUN
admet-280	16	6	responsible	responsible	ADJ
admet-280	16	7	for	for	ADP
admet-280	16	8	oxidative	oxidative	ADJ
admet-280	16	9	drug	drug	NOUN
admet-280	16	10	metabolism	metabolism	NOUN
admet-280	16	11	is	be	AUX
admet-280	16	12	the	the	DET
admet-280	16	13	cytochrome	cytochrome	ADJ
admet-280	16	14	p450s	p450s	PROPN
admet-280	16	15	(	(	PUNCT
admet-280	16	16	cyps	cyps	PROPN
admet-280	16	17	)	)	PUNCT
admet-280	16	18	,	,	PUNCT
admet-280	16	19	in	in	ADP
admet-280	16	20	particular	particular	ADJ
admet-280	16	21	members	member	NOUN
admet-280	16	22	of	of	ADP
admet-280	16	23	just	just	ADV
admet-280	16	24	three	three	NUM
admet-280	16	25	subfamilies	subfamily	NOUN
admet-280	16	26	(	(	PUNCT
admet-280	16	27	cyp1	cyp1	PROPN
admet-280	16	28	,	,	PUNCT
admet-280	16	29	cyp2	cyp2	PROPN
admet-280	16	30	and	and	CCONJ
admet-280	16	31	cyp3	cyp3	PROPN
admet-280	16	32	)	)	PUNCT
admet-280	16	33	are	be	AUX
admet-280	16	34	primarily	primarily	ADV
admet-280	16	35	responsible	responsible	ADJ
admet-280	16	36	for	for	ADP
admet-280	16	37	the	the	DET
admet-280	16	38	metabolism	metabolism	NOUN
admet-280	16	39	of	of	ADP
admet-280	16	40	most	most	ADJ
admet-280	16	41	drugs	drug	NOUN
admet-280	16	42	[	[	X
admet-280	16	43	1	1	NUM
admet-280	16	44	]	]	PUNCT
admet-280	16	45	.	.	PUNCT
admet-280	17	1	the	the	DET
admet-280	17	2	drug	drug	NOUN
admet-280	17	3	-	-	PUNCT
admet-280	17	4	metabolizing	metabolize	VERB
admet-280	17	5	cyps	cyp	NOUN
admet-280	17	6	are	be	AUX
admet-280	17	7	highly	highly	ADV
admet-280	17	8	expressed	express	VERB
admet-280	17	9	in	in	ADP
admet-280	17	10	the	the	DET
admet-280	17	11	liver	liver	NOUN
admet-280	17	12	,	,	PUNCT
admet-280	17	13	making	make	VERB
admet-280	17	14	it	it	PRON
admet-280	17	15	the	the	DET
admet-280	17	16	primary	primary	ADJ
admet-280	17	17	organ	organ	NOUN
admet-280	17	18	to	to	PART
admet-280	17	19	study	study	VERB
admet-280	17	20	for	for	ADP
admet-280	17	21	the	the	DET
admet-280	17	22	metabolism	metabolism	NOUN
admet-280	17	23	,	,	PUNCT
admet-280	17	24	detoxification	detoxification	NOUN
admet-280	17	25	and	and	CCONJ
admet-280	17	26	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-280	17	27	mailto:jennav2@uw.edu	mailto:jennav2@uw.edu	X
admet-280	17	28	mailto:edkelly@uw.edu	mailto:edkelly@uw.edu	X
admet-280	17	29	admet	admet	PROPN
admet-280	17	30	&	&	CCONJ
admet-280	17	31	dmpk	dmpk	PROPN
admet-280	17	32	4(2	4(2	NUM
admet-280	17	33	)	)	PUNCT
admet-280	17	34	(	(	PUNCT
admet-280	17	35	2016	2016	NUM
admet-280	17	36	)	)	PUNCT
admet-280	17	37	62	62	NUM
admet-280	17	38	-	-	SYM
admet-280	17	39	83	83	NUM
admet-280	17	40	pharmacogenetics	pharmacogenetic	NOUN
admet-280	17	41	and	and	CCONJ
admet-280	17	42	cyp	cyp	ADJ
admet-280	17	43	activity	activity	NOUN
admet-280	17	44	doi	doi	NOUN
admet-280	17	45	:	:	PUNCT
admet-280	17	46	10.5599	10.5599	NUM
admet-280	17	47	/	/	SYM
admet-280	17	48	admet.4.2.280	admet.4.2.280	NUM
admet-280	17	49	63	63	NUM
admet-280	17	50	elimination	elimination	NOUN
admet-280	17	51	of	of	ADP
admet-280	17	52	drugs	drug	NOUN
admet-280	17	53	,	,	PUNCT
admet-280	17	54	and	and	CCONJ
admet-280	17	55	the	the	DET
admet-280	17	56	focus	focus	NOUN
admet-280	17	57	of	of	ADP
admet-280	17	58	drug	drug	NOUN
admet-280	17	59	optimization	optimization	NOUN
admet-280	17	60	and	and	CCONJ
admet-280	17	61	safety	safety	NOUN
admet-280	17	62	studies	study	NOUN
admet-280	17	63	[	[	X
admet-280	17	64	2	2	NUM
admet-280	17	65	,	,	PUNCT
admet-280	17	66	3	3	NUM
admet-280	17	67	]	]	PUNCT
admet-280	17	68	.	.	PUNCT
admet-280	18	1	pharmacogenetic	pharmacogenetic	ADJ
admet-280	18	2	variability	variability	NOUN
admet-280	18	3	,	,	PUNCT
admet-280	18	4	in	in	ADP
admet-280	18	5	drug	drug	NOUN
admet-280	18	6	-	-	PUNCT
admet-280	18	7	metabolizing	metabolize	VERB
admet-280	18	8	enzymes	enzyme	NOUN
admet-280	18	9	such	such	ADJ
admet-280	18	10	as	as	ADP
admet-280	18	11	the	the	DET
admet-280	18	12	cyps	cyps	PROPN
admet-280	18	13	,	,	PUNCT
admet-280	18	14	can	can	AUX
admet-280	18	15	influence	influence	VERB
admet-280	18	16	an	an	DET
admet-280	18	17	individual	individual	NOUN
admet-280	18	18	’s	’s	PART
admet-280	18	19	susceptibility	susceptibility	NOUN
admet-280	18	20	to	to	ADP
admet-280	18	21	drug	drug	NOUN
admet-280	18	22	toxicity	toxicity	NOUN
admet-280	18	23	,	,	PUNCT
admet-280	18	24	contributing	contribute	VERB
admet-280	18	25	to	to	PART
admet-280	18	26	observed	observe	VERB
admet-280	18	27	adverse	adverse	ADJ
admet-280	18	28	drug	drug	NOUN
admet-280	18	29	reactions	reaction	NOUN
admet-280	18	30	(	(	PUNCT
admet-280	18	31	adrs	adrs	PROPN
admet-280	18	32	)	)	PUNCT
admet-280	19	1	[	[	X
admet-280	19	2	4	4	NUM
admet-280	19	3	]	]	PUNCT
admet-280	19	4	.	.	PUNCT
admet-280	19	5	drug	drug	NOUN
admet-280	19	6	-	-	PUNCT
admet-280	19	7	drug	drug	NOUN
admet-280	19	8	interactions	interaction	NOUN
admet-280	19	9	are	be	AUX
admet-280	19	10	a	a	DET
admet-280	19	11	major	major	ADJ
admet-280	19	12	concern	concern	NOUN
admet-280	19	13	of	of	ADP
admet-280	19	14	pharmaceutical	pharmaceutical	ADJ
admet-280	19	15	companies	company	NOUN
admet-280	19	16	,	,	PUNCT
admet-280	19	17	particularly	particularly	ADV
admet-280	19	18	with	with	ADP
admet-280	19	19	respect	respect	NOUN
admet-280	19	20	to	to	ADP
admet-280	19	21	adrs	adr	NOUN
admet-280	19	22	,	,	PUNCT
admet-280	19	23	a	a	DET
admet-280	19	24	leading	lead	VERB
admet-280	19	25	cause	cause	NOUN
admet-280	19	26	of	of	ADP
admet-280	19	27	preventable	preventable	ADJ
admet-280	19	28	death	death	NOUN
admet-280	19	29	in	in	ADP
admet-280	19	30	the	the	DET
admet-280	19	31	united	united	PROPN
admet-280	19	32	states	states	PROPN
admet-280	19	33	[	[	X
admet-280	19	34	4	4	NUM
admet-280	19	35	]	]	PUNCT
admet-280	19	36	.	.	PUNCT
admet-280	20	1	primary	primary	ADJ
admet-280	20	2	human	human	ADJ
admet-280	20	3	hepatocytes	hepatocyte	NOUN
admet-280	20	4	are	be	AUX
admet-280	20	5	the	the	DET
admet-280	20	6	most	most	ADV
admet-280	20	7	physiologically	physiologically	ADV
admet-280	20	8	relevant	relevant	ADJ
admet-280	20	9	in	in	ADP
admet-280	20	10	vitro	vitro	X
admet-280	20	11	preclinical	preclinical	ADJ
admet-280	20	12	screening	screening	NOUN
admet-280	20	13	system	system	NOUN
admet-280	20	14	used	use	VERB
admet-280	20	15	to	to	PART
admet-280	20	16	evaluate	evaluate	VERB
admet-280	20	17	drug	drug	NOUN
admet-280	20	18	metabolism	metabolism	NOUN
admet-280	20	19	in	in	ADP
admet-280	20	20	the	the	DET
admet-280	20	21	liver	liver	NOUN
admet-280	20	22	[	[	X
admet-280	20	23	5	5	NUM
admet-280	20	24	]	]	PUNCT
admet-280	20	25	.	.	PUNCT
admet-280	21	1	this	this	PRON
admet-280	21	2	is	be	AUX
admet-280	21	3	due	due	ADJ
admet-280	21	4	to	to	ADP
admet-280	21	5	their	their	PRON
admet-280	21	6	high	high	ADJ
admet-280	21	7	-	-	PUNCT
admet-280	21	8	expression	expression	NOUN
admet-280	21	9	of	of	ADP
admet-280	21	10	phase	phase	NOUN
admet-280	21	11	i	i	PRON
admet-280	21	12	and	and	CCONJ
admet-280	21	13	ii	ii	PROPN
admet-280	21	14	drug	drug	NOUN
admet-280	21	15	-	-	PUNCT
admet-280	21	16	metabolizing	metabolize	VERB
admet-280	21	17	enzymes	enzyme	NOUN
admet-280	21	18	,	,	PUNCT
admet-280	21	19	as	as	ADV
admet-280	21	20	well	well	ADV
admet-280	21	21	as	as	ADP
admet-280	21	22	phase	phase	NOUN
admet-280	21	23	iii	iii	NUM
admet-280	21	24	transporters	transporter	NOUN
admet-280	21	25	.	.	PUNCT
admet-280	22	1	however	however	ADV
admet-280	22	2	,	,	PUNCT
admet-280	22	3	primary	primary	ADJ
admet-280	22	4	human	human	ADJ
admet-280	22	5	hepatocytes	hepatocyte	NOUN
admet-280	22	6	have	have	VERB
admet-280	22	7	certain	certain	ADJ
admet-280	22	8	features	feature	NOUN
admet-280	22	9	that	that	PRON
admet-280	22	10	limit	limit	VERB
admet-280	22	11	their	their	PRON
admet-280	22	12	utility	utility	NOUN
admet-280	22	13	in	in	ADP
admet-280	22	14	preclinical	preclinical	ADJ
admet-280	22	15	drug	drug	NOUN
admet-280	22	16	development	development	NOUN
admet-280	22	17	,	,	PUNCT
admet-280	22	18	including	include	VERB
admet-280	22	19	:	:	PUNCT
admet-280	22	20	high	high	ADJ
admet-280	22	21	donor	donor	NOUN
admet-280	22	22	variability	variability	NOUN
admet-280	22	23	,	,	PUNCT
admet-280	22	24	uncertain	uncertain	ADJ
admet-280	22	25	availability	availability	NOUN
admet-280	22	26	,	,	PUNCT
admet-280	22	27	short	short	ADJ
admet-280	22	28	-	-	PUNCT
admet-280	22	29	term	term	NOUN
admet-280	22	30	survival	survival	NOUN
admet-280	22	31	in	in	ADP
admet-280	22	32	culture	culture	NOUN
admet-280	22	33	,	,	PUNCT
admet-280	22	34	and	and	CCONJ
admet-280	22	35	a	a	DET
admet-280	22	36	rapid	rapid	ADJ
admet-280	22	37	loss	loss	NOUN
admet-280	22	38	of	of	ADP
admet-280	22	39	hepatic	hepatic	ADJ
admet-280	22	40	functions	function	NOUN
admet-280	22	41	in	in	ADP
admet-280	22	42	culture	culture	NOUN
admet-280	22	43	[	[	X
admet-280	22	44	5	5	NUM
admet-280	22	45	-	-	SYM
admet-280	22	46	7	7	NUM
admet-280	22	47	]	]	PUNCT
admet-280	22	48	.	.	PUNCT
admet-280	23	1	stem	stem	NOUN
admet-280	23	2	cell	cell	NOUN
admet-280	23	3	derived	derive	VERB
admet-280	23	4	hepatocytes	hepatocyte	NOUN
admet-280	23	5	(	(	PUNCT
admet-280	23	6	scdhs	scdhs	NOUN
admet-280	23	7	)	)	PUNCT
admet-280	23	8	may	may	AUX
admet-280	23	9	provide	provide	VERB
admet-280	23	10	an	an	DET
admet-280	23	11	alternative	alternative	NOUN
admet-280	23	12	or	or	CCONJ
admet-280	23	13	complementary	complementary	ADJ
admet-280	23	14	in	in	ADP
admet-280	23	15	vitro	vitro	X
admet-280	23	16	tool	tool	NOUN
admet-280	23	17	to	to	ADP
admet-280	23	18	primary	primary	ADJ
admet-280	23	19	human	human	ADJ
admet-280	23	20	hepatocytes	hepatocyte	NOUN
admet-280	23	21	for	for	ADP
admet-280	23	22	evaluating	evaluate	VERB
admet-280	23	23	drug	drug	NOUN
admet-280	23	24	metabolism	metabolism	NOUN
admet-280	23	25	and	and	CCONJ
admet-280	23	26	liver	liver	NOUN
admet-280	23	27	toxicity	toxicity	NOUN
admet-280	23	28	characteristics	characteristic	NOUN
admet-280	23	29	.	.	PUNCT
admet-280	24	1	pluripotent	pluripotent	ADJ
admet-280	24	2	stem	stem	NOUN
admet-280	24	3	cells	cell	NOUN
admet-280	24	4	have	have	VERB
admet-280	24	5	high	high	ADJ
admet-280	24	6	self	self	NOUN
admet-280	24	7	-	-	PUNCT
admet-280	24	8	renewal	renewal	NOUN
admet-280	24	9	abilities	ability	NOUN
admet-280	24	10	,	,	PUNCT
admet-280	24	11	providing	provide	VERB
admet-280	24	12	a	a	DET
admet-280	24	13	potentially	potentially	ADV
admet-280	24	14	unlimited	unlimited	ADJ
admet-280	24	15	source	source	NOUN
admet-280	24	16	of	of	ADP
admet-280	24	17	hepatocytes	hepatocyte	NOUN
admet-280	24	18	of	of	ADP
admet-280	24	19	defined	define	VERB
admet-280	24	20	genotype	genotype	NOUN
admet-280	24	21	and	and	CCONJ
admet-280	24	22	phenotype	phenotype	NOUN
admet-280	24	23	[	[	X
admet-280	24	24	6	6	NUM
admet-280	24	25	,	,	PUNCT
admet-280	24	26	8	8	NUM
admet-280	24	27	]	]	PUNCT
admet-280	24	28	.	.	PUNCT
admet-280	25	1	in	in	ADP
admet-280	25	2	order	order	NOUN
admet-280	25	3	for	for	ADP
admet-280	25	4	scdhs	scdhs	ADJ
admet-280	25	5	to	to	PART
admet-280	25	6	become	become	VERB
admet-280	25	7	routinely	routinely	ADV
admet-280	25	8	used	use	VERB
admet-280	25	9	in	in	ADP
admet-280	25	10	preclinical	preclinical	ADJ
admet-280	25	11	drug	drug	NOUN
admet-280	25	12	metabolism	metabolism	NOUN
admet-280	25	13	and	and	CCONJ
admet-280	25	14	toxicity	toxicity	NOUN
admet-280	25	15	screening	screening	NOUN
admet-280	25	16	,	,	PUNCT
admet-280	25	17	they	they	PRON
admet-280	25	18	must	must	AUX
admet-280	25	19	demonstrate	demonstrate	VERB
admet-280	25	20	reproducible	reproducible	ADJ
admet-280	25	21	activity	activity	NOUN
admet-280	25	22	of	of	ADP
admet-280	25	23	drug	drug	NOUN
admet-280	25	24	metabolism	metabolism	NOUN
admet-280	25	25	proteins	protein	NOUN
admet-280	25	26	,	,	PUNCT
admet-280	25	27	particularly	particularly	ADV
admet-280	25	28	the	the	DET
admet-280	25	29	oxidative	oxidative	ADJ
admet-280	25	30	cyp	cyp	ADJ
admet-280	25	31	enzymes	enzyme	NOUN
admet-280	25	32	.	.	PUNCT
admet-280	26	1	additionally	additionally	ADV
admet-280	26	2	,	,	PUNCT
admet-280	26	3	it	it	PRON
admet-280	26	4	would	would	AUX
admet-280	26	5	be	be	AUX
admet-280	26	6	ideal	ideal	ADJ
admet-280	26	7	if	if	SCONJ
admet-280	26	8	scdhs	scdhs	ADJ
admet-280	26	9	produced	produce	VERB
admet-280	26	10	metabolic	metabolic	NOUN
admet-280	26	11	activities	activity	NOUN
admet-280	26	12	comparable	comparable	ADJ
admet-280	26	13	to	to	ADP
admet-280	26	14	that	that	PRON
admet-280	26	15	of	of	ADP
admet-280	26	16	primary	primary	ADJ
admet-280	26	17	human	human	ADJ
admet-280	26	18	hepatocytes	hepatocyte	NOUN
admet-280	26	19	.	.	PUNCT
admet-280	27	1	since	since	SCONJ
admet-280	27	2	scdhs	scdhs	ADV
admet-280	27	3	have	have	AUX
admet-280	27	4	defined	define	VERB
admet-280	27	5	genotypes	genotype	NOUN
admet-280	27	6	,	,	PUNCT
admet-280	27	7	they	they	PRON
admet-280	27	8	may	may	AUX
admet-280	27	9	also	also	ADV
admet-280	27	10	provide	provide	VERB
admet-280	27	11	an	an	DET
admet-280	27	12	improved	improved	ADJ
admet-280	27	13	system	system	NOUN
admet-280	27	14	for	for	ADP
admet-280	27	15	evaluating	evaluate	VERB
admet-280	27	16	genotypephenotype	genotypephenotype	NOUN
admet-280	27	17	relationships	relationship	NOUN
admet-280	27	18	,	,	PUNCT
admet-280	27	19	e.g.	e.g.	ADV
admet-280	27	20	cyp	cyp	ADJ
admet-280	27	21	gene	gene	NOUN
admet-280	27	22	polymorphisms	polymorphism	NOUN
admet-280	27	23	and	and	CCONJ
admet-280	27	24	their	their	PRON
admet-280	27	25	impact	impact	NOUN
admet-280	27	26	on	on	ADP
admet-280	27	27	drug	drug	NOUN
admet-280	27	28	metabolism	metabolism	NOUN
admet-280	27	29	and	and	CCONJ
admet-280	27	30	toxicity	toxicity	NOUN
admet-280	27	31	,	,	PUNCT
admet-280	27	32	and	and	CCONJ
admet-280	27	33	in	in	ADP
admet-280	27	34	particular	particular	ADJ
admet-280	27	35	drug	drug	NOUN
admet-280	27	36	-	-	PUNCT
admet-280	27	37	induced	induce	VERB
admet-280	27	38	liver	liver	NOUN
admet-280	27	39	injury	injury	NOUN
admet-280	27	40	.	.	PUNCT
admet-280	28	1	overall	overall	ADJ
admet-280	28	2	,	,	PUNCT
admet-280	28	3	published	publish	VERB
admet-280	28	4	studies	study	NOUN
admet-280	28	5	demonstrate	demonstrate	VERB
admet-280	28	6	that	that	SCONJ
admet-280	28	7	scdhs	scdhs	PROPN
admet-280	28	8	generated	generate	VERB
admet-280	28	9	from	from	ADP
admet-280	28	10	either	either	CCONJ
admet-280	28	11	human	human	ADJ
admet-280	28	12	embryonic	embryonic	ADJ
admet-280	28	13	stem	stem	NOUN
admet-280	28	14	cells	cell	NOUN
admet-280	28	15	(	(	PUNCT
admet-280	28	16	hescs	hesc	NOUN
admet-280	28	17	)	)	PUNCT
admet-280	28	18	or	or	CCONJ
admet-280	28	19	induced	induce	VERB
admet-280	28	20	pluripotent	pluripotent	ADJ
admet-280	28	21	stem	stem	NOUN
admet-280	28	22	cells	cell	NOUN
admet-280	28	23	(	(	PUNCT
admet-280	28	24	ipscs	ipscs	NOUN
admet-280	28	25	)	)	PUNCT
admet-280	28	26	,	,	PUNCT
admet-280	28	27	do	do	AUX
admet-280	28	28	express	express	VERB
admet-280	28	29	cyps	cyp	NOUN
admet-280	28	30	and	and	CCONJ
admet-280	28	31	other	other	ADJ
admet-280	28	32	drug	drug	NOUN
admet-280	28	33	-	-	PUNCT
admet-280	28	34	metabolizing	metabolize	VERB
admet-280	28	35	enzymes	enzyme	NOUN
admet-280	28	36	,	,	PUNCT
admet-280	28	37	however	however	ADV
admet-280	28	38	they	they	PRON
admet-280	28	39	seem	seem	VERB
admet-280	28	40	to	to	PART
admet-280	28	41	be	be	AUX
admet-280	28	42	at	at	ADP
admet-280	28	43	levels	level	NOUN
admet-280	28	44	below	below	ADP
admet-280	28	45	those	those	PRON
admet-280	28	46	in	in	ADP
admet-280	28	47	primary	primary	ADJ
admet-280	28	48	human	human	ADJ
admet-280	28	49	hepatocytes	hepatocyte	NOUN
admet-280	28	50	.	.	PUNCT
admet-280	29	1	in	in	ADP
admet-280	29	2	addition	addition	NOUN
admet-280	29	3	,	,	PUNCT
admet-280	29	4	the	the	DET
admet-280	29	5	majority	majority	NOUN
admet-280	29	6	of	of	ADP
admet-280	29	7	studies	study	NOUN
admet-280	29	8	have	have	AUX
admet-280	29	9	also	also	ADV
admet-280	29	10	reported	report	VERB
admet-280	29	11	scdhs	scdhs	ADJ
admet-280	29	12	as	as	ADP
admet-280	29	13	still	still	ADV
admet-280	29	14	expressing	express	VERB
admet-280	29	15	α	α	NOUN
admet-280	29	16	-	-	ADJ
admet-280	29	17	fetoprotein	fetoprotein	ADJ
admet-280	29	18	(	(	PUNCT
admet-280	29	19	afp	afp	NOUN
admet-280	29	20	)	)	PUNCT
admet-280	29	21	,	,	PUNCT
admet-280	29	22	which	which	PRON
admet-280	29	23	is	be	AUX
admet-280	29	24	highly	highly	ADV
admet-280	29	25	expressed	express	VERB
admet-280	29	26	in	in	ADP
admet-280	29	27	fetal	fetal	ADJ
admet-280	29	28	livers	liver	NOUN
admet-280	29	29	and	and	CCONJ
admet-280	29	30	not	not	PART
admet-280	29	31	typically	typically	ADV
admet-280	29	32	expressed	express	VERB
admet-280	29	33	in	in	ADP
admet-280	29	34	healthy	healthy	ADJ
admet-280	29	35	adult	adult	NOUN
admet-280	29	36	livers	liver	NOUN
admet-280	29	37	,	,	PUNCT
admet-280	29	38	indicating	indicate	VERB
admet-280	29	39	the	the	DET
admet-280	29	40	cells	cell	NOUN
admet-280	29	41	may	may	AUX
admet-280	29	42	still	still	ADV
admet-280	29	43	be	be	AUX
admet-280	29	44	in	in	ADP
admet-280	29	45	an	an	DET
admet-280	29	46	immature	immature	ADJ
admet-280	29	47	state	state	NOUN
admet-280	29	48	.	.	PUNCT
admet-280	30	1	despite	despite	SCONJ
admet-280	30	2	the	the	DET
admet-280	30	3	advances	advance	NOUN
admet-280	30	4	made	make	VERB
admet-280	30	5	in	in	ADP
admet-280	30	6	generating	generate	VERB
admet-280	30	7	scdhs	scdhs	NOUN
admet-280	30	8	,	,	PUNCT
admet-280	30	9	the	the	DET
admet-280	30	10	biggest	big	ADJ
admet-280	30	11	limitation	limitation	NOUN
admet-280	30	12	in	in	ADP
admet-280	30	13	the	the	DET
admet-280	30	14	field	field	NOUN
admet-280	30	15	to	to	ADP
admet-280	30	16	date	date	NOUN
admet-280	30	17	is	be	AUX
admet-280	30	18	the	the	DET
admet-280	30	19	inability	inability	NOUN
admet-280	30	20	to	to	PART
admet-280	30	21	reproducibly	reproducibly	ADV
admet-280	30	22	and	and	CCONJ
admet-280	30	23	consistently	consistently	ADV
admet-280	30	24	generate	generate	VERB
admet-280	30	25	mature	mature	ADJ
admet-280	30	26	hepatocytes	hepatocyte	NOUN
admet-280	30	27	with	with	ADP
admet-280	30	28	high	high	ADJ
admet-280	30	29	levels	level	NOUN
admet-280	30	30	of	of	ADP
admet-280	30	31	functional	functional	ADJ
admet-280	30	32	drug	drug	NOUN
admet-280	30	33	metabolizing	metabolize	VERB
admet-280	30	34	enzymes	enzyme	NOUN
admet-280	30	35	.	.	PUNCT
admet-280	31	1	in	in	ADP
admet-280	31	2	order	order	NOUN
admet-280	31	3	for	for	ADP
admet-280	31	4	scdhs	scdhs	ADJ
admet-280	31	5	to	to	PART
admet-280	31	6	be	be	AUX
admet-280	31	7	successfully	successfully	ADV
admet-280	31	8	used	use	VERB
admet-280	31	9	as	as	ADP
admet-280	31	10	an	an	DET
admet-280	31	11	in	in	ADP
admet-280	31	12	vitro	vitro	X
admet-280	31	13	assay	assay	NOUN
admet-280	31	14	platform	platform	NOUN
admet-280	31	15	for	for	ADP
admet-280	31	16	metabolite	metabolite	NOUN
admet-280	31	17	profiling	profiling	NOUN
admet-280	31	18	,	,	PUNCT
admet-280	31	19	this	this	PRON
admet-280	31	20	is	be	AUX
admet-280	31	21	something	something	PRON
admet-280	31	22	that	that	PRON
admet-280	31	23	must	must	AUX
admet-280	31	24	be	be	AUX
admet-280	31	25	overcome	overcome	VERB
admet-280	31	26	.	.	PUNCT
admet-280	32	1	this	this	PRON
admet-280	32	2	indicates	indicate	VERB
admet-280	32	3	there	there	PRON
admet-280	32	4	is	be	VERB
admet-280	32	5	a	a	DET
admet-280	32	6	significant	significant	ADJ
admet-280	32	7	need	need	NOUN
admet-280	32	8	for	for	ADP
admet-280	32	9	improvement	improvement	NOUN
admet-280	32	10	on	on	ADP
admet-280	32	11	generating	generate	VERB
admet-280	32	12	and	and	CCONJ
admet-280	32	13	characterizing	characterize	VERB
admet-280	32	14	scdhs	scdhs	NOUN
admet-280	32	15	,	,	PUNCT
admet-280	32	16	particularly	particularly	ADV
admet-280	32	17	with	with	ADP
admet-280	32	18	regards	regard	NOUN
admet-280	32	19	to	to	ADP
admet-280	32	20	their	their	PRON
admet-280	32	21	metabolic	metabolic	NOUN
admet-280	32	22	capacity	capacity	NOUN
admet-280	32	23	as	as	SCONJ
admet-280	32	24	it	it	PRON
admet-280	32	25	compares	compare	VERB
admet-280	32	26	to	to	ADP
admet-280	32	27	primary	primary	ADJ
admet-280	32	28	human	human	ADJ
admet-280	32	29	hepatocytes	hepatocyte	NOUN
admet-280	32	30	.	.	PUNCT
admet-280	33	1	we	we	PRON
admet-280	33	2	sought	seek	VERB
admet-280	33	3	to	to	PART
admet-280	33	4	further	far	ADV
admet-280	33	5	investigate	investigate	VERB
admet-280	33	6	the	the	DET
admet-280	33	7	state	state	NOUN
admet-280	33	8	of	of	ADP
admet-280	33	9	scdhs	scdhs	NOUN
admet-280	33	10	as	as	SCONJ
admet-280	33	11	they	they	PRON
admet-280	33	12	compare	compare	VERB
admet-280	33	13	to	to	ADP
admet-280	33	14	cryopreserved	cryopreserve	VERB
admet-280	33	15	human	human	ADJ
admet-280	33	16	hepatocytes	hepatocyte	NOUN
admet-280	33	17	,	,	PUNCT
admet-280	33	18	with	with	ADP
admet-280	33	19	emphasis	emphasis	NOUN
admet-280	33	20	on	on	ADP
admet-280	33	21	the	the	DET
admet-280	33	22	expression	expression	NOUN
admet-280	33	23	and	and	CCONJ
admet-280	33	24	functional	functional	ADJ
admet-280	33	25	capacity	capacity	NOUN
admet-280	33	26	of	of	ADP
admet-280	33	27	drug	drug	NOUN
admet-280	33	28	-	-	PUNCT
admet-280	33	29	metabolizing	metabolize	VERB
admet-280	33	30	enzymes	enzyme	NOUN
admet-280	33	31	.	.	PUNCT
admet-280	34	1	this	this	PRON
admet-280	34	2	was	be	AUX
admet-280	34	3	done	do	VERB
admet-280	34	4	in	in	ADP
admet-280	34	5	part	part	NOUN
admet-280	34	6	through	through	ADP
admet-280	34	7	gene	gene	NOUN
admet-280	34	8	expression	expression	NOUN
admet-280	34	9	profiling	profiling	NOUN
admet-280	34	10	of	of	ADP
admet-280	34	11	pluripotency	pluripotency	ADJ
admet-280	34	12	markers	marker	NOUN
admet-280	34	13	,	,	PUNCT
admet-280	34	14	hepatocyte	hepatocyte	NOUN
admet-280	34	15	markers	marker	NOUN
admet-280	34	16	,	,	PUNCT
admet-280	34	17	drug	drug	NOUN
admet-280	34	18	-	-	PUNCT
admet-280	34	19	metabolizing	metabolize	VERB
admet-280	34	20	enzymes	enzyme	NOUN
admet-280	34	21	and	and	CCONJ
admet-280	34	22	transporters	transporter	NOUN
admet-280	34	23	.	.	PUNCT
admet-280	35	1	to	to	PART
admet-280	35	2	evaluate	evaluate	VERB
admet-280	35	3	the	the	DET
admet-280	35	4	functional	functional	ADJ
admet-280	35	5	capacity	capacity	NOUN
admet-280	35	6	of	of	ADP
admet-280	35	7	cyp	cyp	ADJ
admet-280	35	8	enzymes	enzyme	NOUN
admet-280	35	9	in	in	ADP
admet-280	35	10	scdhs	scdhs	ADJ
admet-280	35	11	,	,	PUNCT
admet-280	35	12	metabolite	metabolite	NOUN
admet-280	35	13	formation	formation	NOUN
admet-280	35	14	was	be	AUX
admet-280	35	15	assessed	assess	VERB
admet-280	35	16	using	use	VERB
admet-280	35	17	a	a	DET
admet-280	35	18	cyp	cyp	ADJ
admet-280	35	19	cocktail	cocktail	NOUN
admet-280	35	20	approach	approach	NOUN
admet-280	35	21	and	and	CCONJ
admet-280	35	22	lc	lc	PROPN
admet-280	35	23	-	-	PUNCT
admet-280	35	24	ms	ms	PROPN
admet-280	35	25	/	/	SYM
admet-280	35	26	ms	ms	PROPN
admet-280	35	27	.	.	PROPN
admet-280	35	28	additionally	additionally	ADV
admet-280	35	29	,	,	PUNCT
admet-280	35	30	to	to	PART
admet-280	35	31	demonstrate	demonstrate	VERB
admet-280	35	32	the	the	DET
admet-280	35	33	utility	utility	NOUN
admet-280	35	34	of	of	ADP
admet-280	35	35	scdhs	scdhs	NOUN
admet-280	35	36	in	in	ADP
admet-280	35	37	pharmacogenetic	pharmacogenetic	ADJ
admet-280	35	38	predictive	predictive	ADJ
admet-280	35	39	screening	screening	NOUN
admet-280	35	40	,	,	PUNCT
admet-280	35	41	we	we	PRON
admet-280	35	42	sought	seek	VERB
admet-280	35	43	to	to	PART
admet-280	35	44	genetically	genetically	ADV
admet-280	35	45	profile	profile	VERB
admet-280	35	46	the	the	DET
admet-280	35	47	commonly	commonly	ADV
admet-280	35	48	used	use	VERB
admet-280	35	49	wicell	wicell	PROPN
admet-280	35	50	®	®	NOUN
admet-280	35	51	hesc	hesc	PROPN
admet-280	35	52	lines	lines	PROPN
admet-280	35	53	h1	h1	PROPN
admet-280	35	54	,	,	PUNCT
admet-280	35	55	h7	h7	PROPN
admet-280	35	56	,	,	PUNCT
admet-280	35	57	h9	h9	NOUN
admet-280	35	58	,	,	PUNCT
admet-280	35	59	h13	h13	NOUN
admet-280	35	60	and	and	CCONJ
admet-280	35	61	h14	h14	NOUN
admet-280	35	62	using	use	VERB
admet-280	35	63	the	the	DET
admet-280	35	64	affymetrix	affymetrix	ADJ
admet-280	35	65	dmet	dmet	NOUN
admet-280	35	66	™	™	NOUN
admet-280	35	67	plus	plus	CCONJ
admet-280	35	68	chip	chip	NOUN
admet-280	35	69	array	array	NOUN
admet-280	35	70	.	.	PUNCT
admet-280	36	1	this	this	DET
admet-280	36	2	array	array	NOUN
admet-280	36	3	covers	cover	VERB
admet-280	36	4	approximately	approximately	ADV
admet-280	36	5	2000	2000	NUM
admet-280	36	6	polymorphisms	polymorphism	NOUN
admet-280	36	7	in	in	ADP
admet-280	36	8	absorption	absorption	NOUN
admet-280	36	9	,	,	PUNCT
admet-280	36	10	distribution	distribution	NOUN
admet-280	36	11	,	,	PUNCT
admet-280	36	12	metabolism	metabolism	NOUN
admet-280	36	13	and	and	CCONJ
admet-280	36	14	excretion	excretion	NOUN
admet-280	36	15	(	(	PUNCT
admet-280	36	16	adme	adme	NOUN
admet-280	36	17	)	)	PUNCT
admet-280	36	18	relevant	relevant	ADJ
admet-280	36	19	genes	gene	NOUN
admet-280	36	20	.	.	PUNCT
admet-280	37	1	we	we	PRON
admet-280	37	2	focused	focus	VERB
admet-280	37	3	on	on	ADP
admet-280	37	4	cyp2d6	cyp2d6	NOUN
admet-280	37	5	in	in	ADP
admet-280	37	6	our	our	PRON
admet-280	37	7	analysis	analysis	NOUN
admet-280	37	8	in	in	ADP
admet-280	37	9	utilizing	utilize	VERB
admet-280	37	10	scdhs	scdhs	ADV
admet-280	37	11	for	for	ADP
admet-280	37	12	genotype	genotype	NOUN
admet-280	37	13	-	-	PUNCT
admet-280	37	14	phenotype	phenotype	NOUN
admet-280	37	15	predictions	prediction	NOUN
admet-280	37	16	,	,	PUNCT
admet-280	37	17	given	give	VERB
admet-280	37	18	its	its	PRON
admet-280	37	19	highly	highly	ADV
admet-280	37	20	polymorphic	polymorphic	ADJ
admet-280	37	21	nature	nature	NOUN
admet-280	37	22	and	and	CCONJ
admet-280	37	23	role	role	NOUN
admet-280	37	24	in	in	ADP
admet-280	37	25	metabolizing	metabolize	VERB
admet-280	37	26	about	about	ADV
admet-280	37	27	20	20	NUM
admet-280	37	28	%	%	NOUN
admet-280	37	29	of	of	ADP
admet-280	37	30	marketed	market	VERB
admet-280	37	31	drugs	drug	NOUN
admet-280	37	32	[	[	X
admet-280	37	33	9	9	NUM
admet-280	37	34	,	,	PUNCT
admet-280	37	35	10	10	NUM
admet-280	37	36	]	]	PUNCT
admet-280	37	37	.	.	PUNCT
admet-280	38	1	in	in	ADP
admet-280	38	2	terms	term	NOUN
admet-280	38	3	of	of	ADP
admet-280	38	4	testing	test	VERB
admet-280	38	5	genotype	genotype	NOUN
admet-280	38	6	-	-	PUNCT
admet-280	38	7	phenotype	phenotype	NOUN
admet-280	38	8	relationships	relationship	NOUN
admet-280	38	9	for	for	ADP
admet-280	38	10	cyp2d6	cyp2d6	NOUN
admet-280	38	11	in	in	ADP
admet-280	38	12	scdhs	scdhs	PROPN
admet-280	38	13	,	,	PUNCT
admet-280	38	14	we	we	PRON
admet-280	38	15	assessed	assess	VERB
admet-280	38	16	the	the	DET
admet-280	38	17	penetrance	penetrance	NOUN
admet-280	38	18	of	of	ADP
admet-280	38	19	cyp2d6	cyp2d6	NOUN
admet-280	38	20	*	*	SYM
admet-280	38	21	41	41	NUM
admet-280	38	22	,	,	PUNCT
admet-280	38	23	a	a	DET
admet-280	38	24	splicing	splicing	NOUN
admet-280	38	25	defect	defect	NOUN
admet-280	38	26	which	which	PRON
admet-280	38	27	results	result	VERB
admet-280	38	28	in	in	ADP
admet-280	38	29	a	a	DET
admet-280	38	30	cyp2d6	cyp2d6	NOUN
admet-280	38	31	splice	splice	NOUN
admet-280	38	32	product	product	NOUN
admet-280	38	33	lacking	lack	VERB
admet-280	38	34	exon	exon	NOUN
admet-280	38	35	6	6	NUM
admet-280	38	36	,	,	PUNCT
admet-280	38	37	through	through	ADP
admet-280	38	38	use	use	NOUN
admet-280	38	39	of	of	ADP
admet-280	38	40	a	a	DET
admet-280	38	41	reverse	reverse	NOUN
admet-280	38	42	-	-	PUNCT
admet-280	38	43	transcription	transcription	NOUN
admet-280	38	44	pcr	pcr	NOUN
admet-280	38	45	assay	assay	NOUN
admet-280	38	46	.	.	PUNCT
admet-280	39	1	voellinger	voellinger	VERB
admet-280	39	2	and	and	CCONJ
admet-280	39	3	kelly	kelly	PROPN
admet-280	39	4	admet	admet	PROPN
admet-280	39	5	&	&	CCONJ
admet-280	39	6	dmpk	dmpk	PROPN
admet-280	39	7	4(2	4(2	NUM
admet-280	39	8	)	)	PUNCT
admet-280	39	9	(	(	PUNCT
admet-280	39	10	2016	2016	NUM
admet-280	39	11	)	)	PUNCT
admet-280	39	12	62	62	NUM
admet-280	39	13	-	-	SYM
admet-280	39	14	83	83	NUM
admet-280	39	15	64	64	NUM
admet-280	39	16	experimental	experimental	ADJ
admet-280	39	17	pluripotent	pluripotent	NOUN
admet-280	39	18	stem	stem	NOUN
admet-280	39	19	cells	cell	NOUN
admet-280	39	20	the	the	DET
admet-280	39	21	hesc	hesc	PROPN
admet-280	39	22	lines	lines	PROPN
admet-280	39	23	h1	h1	PROPN
admet-280	39	24	(	(	PUNCT
admet-280	39	25	wa01	wa01	PROPN
admet-280	39	26	)	)	PUNCT
admet-280	39	27	,	,	PUNCT
admet-280	39	28	h7	h7	PROPN
admet-280	39	29	(	(	PUNCT
admet-280	39	30	wa07	wa07	PROPN
admet-280	39	31	)	)	PUNCT
admet-280	39	32	,	,	PUNCT
admet-280	39	33	h9	h9	NOUN
admet-280	39	34	(	(	PUNCT
admet-280	39	35	wa09	wa09	PROPN
admet-280	39	36	)	)	PUNCT
admet-280	39	37	,	,	PUNCT
admet-280	39	38	h13	h13	X
admet-280	39	39	(	(	PUNCT
admet-280	39	40	wa13	wa13	PROPN
admet-280	39	41	)	)	PUNCT
admet-280	39	42	,	,	PUNCT
admet-280	39	43	and	and	CCONJ
admet-280	39	44	h14	h14	NOUN
admet-280	39	45	(	(	PUNCT
admet-280	39	46	wa14	wa14	PROPN
admet-280	39	47	)	)	PUNCT
admet-280	39	48	were	be	AUX
admet-280	39	49	obtained	obtain	VERB
admet-280	39	50	from	from	ADP
admet-280	39	51	wicell	wicell	PROPN
admet-280	39	52	®	®	PROPN
admet-280	39	53	research	research	NOUN
admet-280	39	54	institute	institute	PROPN
admet-280	39	55	(	(	PUNCT
admet-280	39	56	madison	madison	PROPN
admet-280	39	57	,	,	PUNCT
admet-280	39	58	wi	wi	PROPN
admet-280	39	59	,	,	PUNCT
admet-280	39	60	http://www.wicell.org	http://www.wicell.org	NUM
admet-280	39	61	)	)	PUNCT
admet-280	39	62	and	and	CCONJ
admet-280	39	63	propagated	propagate	VERB
admet-280	39	64	at	at	ADP
admet-280	39	65	the	the	DET
admet-280	39	66	university	university	PROPN
admet-280	39	67	of	of	ADP
admet-280	39	68	washington	washington	PROPN
admet-280	39	69	(	(	PUNCT
admet-280	39	70	uw	uw	PROPN
admet-280	39	71	)	)	PUNCT
admet-280	39	72	institute	institute	NOUN
admet-280	39	73	for	for	ADP
admet-280	39	74	stem	stem	NOUN
admet-280	39	75	cell	cell	NOUN
admet-280	39	76	and	and	CCONJ
admet-280	39	77	regenerative	regenerative	ADJ
admet-280	39	78	medicine	medicine	NOUN
admet-280	39	79	.	.	PUNCT
admet-280	40	1	all	all	DET
admet-280	40	2	studies	study	NOUN
admet-280	40	3	were	be	AUX
admet-280	40	4	conducted	conduct	VERB
admet-280	40	5	under	under	ADP
admet-280	40	6	approval	approval	NOUN
admet-280	40	7	of	of	ADP
admet-280	40	8	the	the	DET
admet-280	40	9	university	university	PROPN
admet-280	40	10	of	of	ADP
admet-280	40	11	washington	washington	PROPN
admet-280	40	12	embryonic	embryonic	ADJ
admet-280	40	13	stem	stem	NOUN
admet-280	40	14	cell	cell	NOUN
admet-280	40	15	research	research	NOUN
admet-280	40	16	oversight	oversight	NOUN
admet-280	40	17	committee	committee	NOUN
admet-280	40	18	.	.	PUNCT
admet-280	41	1	cryopreserved	cryopreserve	VERB
admet-280	41	2	human	human	ADJ
admet-280	41	3	hepatocytes	hepatocyte	NOUN
admet-280	41	4	and	and	CCONJ
admet-280	41	5	heparg	heparg	NOUN
admet-280	41	6	cells	cell	NOUN
admet-280	41	7	cryopreserved	cryopreserve	VERB
admet-280	41	8	human	human	ADJ
admet-280	41	9	hepatocyte	hepatocyte	NOUN
admet-280	41	10	lots	lot	NOUN
admet-280	41	11	hu8110	hu8110	PROPN
admet-280	41	12	and	and	CCONJ
admet-280	41	13	hu8114	hu8114	PROPN
admet-280	41	14	were	be	AUX
admet-280	41	15	purchased	purchase	VERB
admet-280	41	16	from	from	ADP
admet-280	41	17	invitrogen	invitrogen	PROPN
admet-280	41	18	(	(	PUNCT
admet-280	41	19	carlsbad	carlsbad	PROPN
admet-280	41	20	,	,	PUNCT
admet-280	41	21	ca	ca	NOUN
admet-280	41	22	)	)	PUNCT
admet-280	41	23	and	and	CCONJ
admet-280	41	24	cultured	cultured	ADJ
admet-280	41	25	according	accord	VERB
admet-280	41	26	to	to	ADP
admet-280	41	27	manufacturer	manufacturer	NOUN
admet-280	41	28	’s	’s	PART
admet-280	41	29	instructions	instruction	NOUN
admet-280	41	30	.	.	PUNCT
admet-280	42	1	briefly	briefly	ADV
admet-280	42	2	,	,	PUNCT
admet-280	42	3	cells	cell	NOUN
admet-280	42	4	were	be	AUX
admet-280	42	5	thawed	thaw	VERB
admet-280	42	6	in	in	ADP
admet-280	42	7	chrm	chrm	ADJ
admet-280	42	8	®	®	NOUN
admet-280	42	9	media	medium	NOUN
admet-280	42	10	and	and	CCONJ
admet-280	42	11	plated	plate	VERB
admet-280	42	12	in	in	ADP
admet-280	42	13	williams	williams	PROPN
admet-280	42	14	medium	medium	NOUN
admet-280	42	15	e	e	PROPN
admet-280	42	16	supplemented	supplement	VERB
admet-280	42	17	with	with	ADP
admet-280	42	18	hepatocyte	hepatocyte	NOUN
admet-280	42	19	plating	plating	NOUN
admet-280	42	20	supplement	supplement	NOUN
admet-280	42	21	pack	pack	NOUN
admet-280	42	22	from	from	ADP
admet-280	42	23	invitrogen	invitrogen	PROPN
admet-280	42	24	on	on	ADP
admet-280	42	25	24	24	NUM
admet-280	42	26	-	-	PUNCT
admet-280	42	27	well	well	NOUN
admet-280	42	28	plates	plate	NOUN
admet-280	42	29	coated	coat	VERB
admet-280	42	30	with	with	ADP
admet-280	42	31	rat	rat	NOUN
admet-280	42	32	collagen	collagen	PROPN
admet-280	42	33	i.	i.	PROPN
admet-280	42	34	following	follow	VERB
admet-280	42	35	a	a	DET
admet-280	42	36	6	6	NUM
admet-280	42	37	-	-	PUNCT
admet-280	42	38	hour	hour	NOUN
admet-280	42	39	incubation	incubation	NOUN
admet-280	42	40	period	period	NOUN
admet-280	42	41	to	to	PART
admet-280	42	42	allow	allow	VERB
admet-280	42	43	for	for	ADP
admet-280	42	44	cell	cell	NOUN
admet-280	42	45	attachment	attachment	NOUN
admet-280	42	46	,	,	PUNCT
admet-280	42	47	the	the	DET
admet-280	42	48	media	medium	NOUN
admet-280	42	49	was	be	AUX
admet-280	42	50	changed	change	VERB
admet-280	42	51	to	to	ADP
admet-280	42	52	williams	williams	PROPN
admet-280	42	53	medium	medium	PROPN
admet-280	42	54	e	e	PROPN
admet-280	42	55	supplemented	supplement	VERB
admet-280	42	56	with	with	ADP
admet-280	42	57	hepatocyte	hepatocyte	NOUN
admet-280	42	58	maintenance	maintenance	NOUN
admet-280	42	59	supplement	supplement	NOUN
admet-280	42	60	pack	pack	NOUN
admet-280	42	61	from	from	ADP
admet-280	42	62	invitrogen	invitrogen	PROPN
admet-280	42	63	.	.	PUNCT
admet-280	43	1	cells	cell	NOUN
admet-280	43	2	were	be	AUX
admet-280	43	3	maintained	maintain	VERB
admet-280	43	4	in	in	ADP
admet-280	43	5	this	this	DET
admet-280	43	6	hepatocyte	hepatocyte	NOUN
admet-280	43	7	maintenance	maintenance	NOUN
admet-280	43	8	media	medium	NOUN
admet-280	43	9	for	for	ADP
admet-280	43	10	4	4	NUM
admet-280	43	11	days	day	NOUN
admet-280	43	12	with	with	ADP
admet-280	43	13	daily	daily	ADJ
admet-280	43	14	fluid	fluid	ADJ
admet-280	43	15	changes	change	NOUN
admet-280	43	16	.	.	PUNCT
admet-280	44	1	cryopreserved	cryopreserve	VERB
admet-280	44	2	human	human	ADJ
admet-280	44	3	hepatocyte	hepatocyte	PROPN
admet-280	44	4	lots	lot	NOUN
admet-280	44	5	hum4012	hum4012	VERB
admet-280	44	6	and	and	CCONJ
admet-280	44	7	hum4034	hum4034	NOUN
admet-280	44	8	were	be	AUX
admet-280	44	9	purchased	purchase	VERB
admet-280	44	10	from	from	ADP
admet-280	44	11	triangle	triangle	NOUN
admet-280	44	12	research	research	NOUN
admet-280	44	13	labs	lab	NOUN
admet-280	44	14	(	(	PUNCT
admet-280	44	15	trl	trl	PROPN
admet-280	44	16	,	,	PUNCT
admet-280	44	17	research	research	NOUN
admet-280	44	18	triangle	triangle	NOUN
admet-280	44	19	park	park	NOUN
admet-280	44	20	,	,	PUNCT
admet-280	44	21	nc	nc	PROPN
admet-280	44	22	)	)	PUNCT
admet-280	44	23	and	and	CCONJ
admet-280	44	24	cultured	cultured	ADJ
admet-280	44	25	according	accord	VERB
admet-280	44	26	to	to	ADP
admet-280	44	27	manufacturer	manufacturer	NOUN
admet-280	44	28	’s	’s	PART
admet-280	44	29	instructions	instruction	NOUN
admet-280	44	30	.	.	PUNCT
admet-280	45	1	briefly	briefly	ADV
admet-280	45	2	,	,	PUNCT
admet-280	45	3	cells	cell	NOUN
admet-280	45	4	were	be	AUX
admet-280	45	5	thawed	thaw	VERB
admet-280	45	6	in	in	ADP
admet-280	45	7	animal	animal	NOUN
admet-280	45	8	thawing	thawing	NOUN
admet-280	45	9	and	and	CCONJ
admet-280	45	10	plating	plating	NOUN
admet-280	45	11	medium	medium	NOUN
admet-280	45	12	from	from	ADP
admet-280	45	13	trl	trl	PROPN
admet-280	45	14	and	and	CCONJ
admet-280	45	15	plated	plate	VERB
admet-280	45	16	in	in	ADP
admet-280	45	17	human	human	ADJ
admet-280	45	18	hepatocyte	hepatocyte	NOUN
admet-280	45	19	plating	plating	NOUN
admet-280	45	20	medium	medium	NOUN
admet-280	45	21	from	from	ADP
admet-280	45	22	trl	trl	PROPN
admet-280	45	23	supplemented	supplement	VERB
admet-280	45	24	with	with	ADP
admet-280	45	25	the	the	DET
admet-280	45	26	plating	plating	NOUN
admet-280	45	27	supplement	supplement	NOUN
admet-280	45	28	on	on	ADP
admet-280	45	29	24	24	NUM
admet-280	45	30	-	-	PUNCT
admet-280	45	31	well	well	NOUN
admet-280	45	32	plates	plate	NOUN
admet-280	45	33	coated	coat	VERB
admet-280	45	34	with	with	ADP
admet-280	45	35	rat	rat	NOUN
admet-280	45	36	collagen	collagen	PROPN
admet-280	45	37	i.	i.	PROPN
admet-280	45	38	following	follow	VERB
admet-280	45	39	a	a	DET
admet-280	45	40	6	6	NUM
admet-280	45	41	-	-	PUNCT
admet-280	45	42	hour	hour	NOUN
admet-280	45	43	incubation	incubation	NOUN
admet-280	45	44	period	period	NOUN
admet-280	45	45	to	to	PART
admet-280	45	46	allow	allow	VERB
admet-280	45	47	for	for	ADP
admet-280	45	48	cell	cell	NOUN
admet-280	45	49	attachment	attachment	NOUN
admet-280	45	50	,	,	PUNCT
admet-280	45	51	the	the	DET
admet-280	45	52	media	medium	NOUN
admet-280	45	53	was	be	AUX
admet-280	45	54	changed	change	VERB
admet-280	45	55	to	to	ADP
admet-280	45	56	hepatocyte	hepatocyte	NOUN
admet-280	45	57	maintenance	maintenance	NOUN
admet-280	45	58	medium	medium	NOUN
admet-280	45	59	supplemented	supplement	VERB
admet-280	45	60	with	with	ADP
admet-280	45	61	the	the	DET
admet-280	45	62	maintenance	maintenance	NOUN
admet-280	45	63	supplement	supplement	NOUN
admet-280	45	64	from	from	ADP
admet-280	45	65	trl	trl	PROPN
admet-280	45	66	.	.	PUNCT
admet-280	46	1	cells	cell	NOUN
admet-280	46	2	were	be	AUX
admet-280	46	3	maintained	maintain	VERB
admet-280	46	4	in	in	ADP
admet-280	46	5	this	this	DET
admet-280	46	6	hepatocyte	hepatocyte	NOUN
admet-280	46	7	maintenance	maintenance	NOUN
admet-280	46	8	media	medium	NOUN
admet-280	46	9	for	for	ADP
admet-280	46	10	3	3	NUM
admet-280	46	11	days	day	NOUN
admet-280	46	12	with	with	ADP
admet-280	46	13	daily	daily	ADJ
admet-280	46	14	fluid	fluid	ADJ
admet-280	46	15	changes	change	NOUN
admet-280	46	16	.	.	PUNCT
admet-280	47	1	in	in	ADP
admet-280	47	2	addition	addition	NOUN
admet-280	47	3	,	,	PUNCT
admet-280	47	4	plated	plate	VERB
admet-280	47	5	primary	primary	ADJ
admet-280	47	6	human	human	ADJ
admet-280	47	7	hepatocytes	hepatocyte	NOUN
admet-280	47	8	were	be	AUX
admet-280	47	9	kindly	kindly	ADV
admet-280	47	10	gifted	gifted	ADJ
admet-280	47	11	from	from	ADP
admet-280	47	12	dr	dr	PROPN
admet-280	47	13	.	.	PROPN
admet-280	47	14	david	david	PROPN
admet-280	47	15	eaton	eaton	PROPN
admet-280	47	16	’s	’s	PART
admet-280	47	17	lab	lab	NOUN
admet-280	47	18	at	at	ADP
admet-280	47	19	the	the	DET
admet-280	47	20	university	university	PROPN
admet-280	47	21	of	of	ADP
admet-280	47	22	washington	washington	PROPN
admet-280	47	23	.	.	PUNCT
admet-280	48	1	undifferentiated	undifferentiated	ADJ
admet-280	48	2	heparg	heparg	NOUN
admet-280	48	3	cells	cell	NOUN
admet-280	48	4	were	be	AUX
admet-280	48	5	obtained	obtain	VERB
admet-280	48	6	from	from	ADP
admet-280	48	7	biopredic	biopredic	ADJ
admet-280	48	8	international	international	PROPN
admet-280	48	9	(	(	PUNCT
admet-280	48	10	saint	saint	PROPN
admet-280	48	11	-	-	PUNCT
admet-280	48	12	gregoire	gregoire	PROPN
admet-280	48	13	,	,	PUNCT
admet-280	48	14	france	france	PROPN
admet-280	48	15	)	)	PUNCT
admet-280	48	16	.	.	PUNCT
admet-280	49	1	undifferentiated	undifferentiated	ADJ
admet-280	49	2	heparg	heparg	NOUN
admet-280	49	3	cells	cell	NOUN
admet-280	49	4	were	be	AUX
admet-280	49	5	cultured	cultured	ADJ
admet-280	49	6	in	in	ADP
admet-280	49	7	williams	williams	PROPN
admet-280	49	8	medium	medium	PROPN
admet-280	49	9	e	e	PROPN
admet-280	49	10	(	(	PUNCT
admet-280	49	11	invitrogen	invitrogen	PROPN
admet-280	49	12	)	)	PUNCT
admet-280	49	13	supplemented	supplement	VERB
admet-280	49	14	with	with	ADP
admet-280	49	15	growth	growth	NOUN
admet-280	49	16	supplement	supplement	NOUN
admet-280	49	17	(	(	PUNCT
admet-280	49	18	biopredic	biopredic	ADJ
admet-280	49	19	)	)	PUNCT
admet-280	49	20	for	for	ADP
admet-280	49	21	2	2	NUM
admet-280	49	22	weeks	week	NOUN
admet-280	49	23	with	with	ADP
admet-280	49	24	fluid	fluid	ADJ
admet-280	49	25	changes	change	NOUN
admet-280	49	26	every	every	DET
admet-280	49	27	2	2	NUM
admet-280	49	28	-	-	SYM
admet-280	49	29	3	3	NUM
admet-280	49	30	days	day	NOUN
admet-280	49	31	.	.	PUNCT
admet-280	50	1	after	after	ADP
admet-280	50	2	2	2	NUM
admet-280	50	3	weeks	week	NOUN
admet-280	50	4	in	in	ADP
admet-280	50	5	culture	culture	NOUN
admet-280	50	6	,	,	PUNCT
admet-280	50	7	heparg	heparg	NOUN
admet-280	50	8	cells	cell	NOUN
admet-280	50	9	were	be	AUX
admet-280	50	10	differentiated	differentiate	VERB
admet-280	50	11	using	use	VERB
admet-280	50	12	a	a	DET
admet-280	50	13	50:50	50:50	NUM
admet-280	50	14	mix	mix	NOUN
admet-280	50	15	of	of	ADP
admet-280	50	16	media	medium	NOUN
admet-280	50	17	supplemented	supplement	VERB
admet-280	50	18	with	with	ADP
admet-280	50	19	growth	growth	NOUN
admet-280	50	20	supplement	supplement	NOUN
admet-280	50	21	and	and	CCONJ
admet-280	50	22	williams	williams	PROPN
admet-280	50	23	medium	medium	PROPN
admet-280	50	24	e	e	PROPN
admet-280	50	25	supplemented	supplement	VERB
admet-280	50	26	with	with	ADP
admet-280	50	27	differentiation	differentiation	NOUN
admet-280	50	28	supplement	supplement	NOUN
admet-280	50	29	(	(	PUNCT
admet-280	50	30	biopredic	biopredic	ADJ
admet-280	50	31	)	)	PUNCT
admet-280	50	32	.	.	PUNCT
admet-280	51	1	after	after	ADP
admet-280	51	2	2	2	NUM
admet-280	51	3	days	day	NOUN
admet-280	51	4	in	in	ADP
admet-280	51	5	culture	culture	NOUN
admet-280	51	6	,	,	PUNCT
admet-280	51	7	cells	cell	NOUN
admet-280	51	8	were	be	AUX
admet-280	51	9	switched	switch	VERB
admet-280	51	10	to	to	ADP
admet-280	51	11	100	100	NUM
admet-280	51	12	%	%	NOUN
admet-280	51	13	media	medium	NOUN
admet-280	51	14	with	with	ADP
admet-280	51	15	differentiation	differentiation	NOUN
admet-280	51	16	supplement	supplement	NOUN
admet-280	51	17	.	.	PUNCT
admet-280	52	1	cells	cell	NOUN
admet-280	52	2	were	be	AUX
admet-280	52	3	maintained	maintain	VERB
admet-280	52	4	in	in	ADP
admet-280	52	5	media	medium	NOUN
admet-280	52	6	with	with	ADP
admet-280	52	7	differentiation	differentiation	NOUN
admet-280	52	8	supplement	supplement	NOUN
admet-280	52	9	for	for	ADP
admet-280	52	10	2	2	NUM
admet-280	52	11	weeks	week	NOUN
admet-280	52	12	,	,	PUNCT
admet-280	52	13	with	with	ADP
admet-280	52	14	fluid	fluid	ADJ
admet-280	52	15	changes	change	NOUN
admet-280	52	16	every	every	DET
admet-280	52	17	2	2	NUM
admet-280	52	18	-	-	SYM
admet-280	52	19	3	3	NUM
admet-280	52	20	days	day	NOUN
admet-280	52	21	.	.	PUNCT
admet-280	53	1	hepatocyte	hepatocyte	NOUN
admet-280	53	2	differentiation	differentiation	NOUN
admet-280	53	3	hescs	hesc	NOUN
admet-280	53	4	were	be	AUX
admet-280	53	5	cultured	cultured	ADJ
admet-280	53	6	on	on	ADP
admet-280	53	7	mouse	mouse	NOUN
admet-280	53	8	embryonic	embryonic	ADJ
admet-280	53	9	fibroblasts	fibroblast	NOUN
admet-280	53	10	(	(	PUNCT
admet-280	53	11	mefs	mef	NOUN
admet-280	53	12	)	)	PUNCT
admet-280	53	13	before	before	ADP
admet-280	53	14	being	be	AUX
admet-280	53	15	transferred	transfer	VERB
admet-280	53	16	to	to	ADP
admet-280	53	17	matrigel	matrigel	NOUN
admet-280	53	18	™	™	ADJ
admet-280	53	19	(	(	PUNCT
admet-280	53	20	bd	bd	PROPN
admet-280	53	21	biosciences	bioscience	NOUN
admet-280	53	22	,	,	PUNCT
admet-280	53	23	san	san	PROPN
admet-280	53	24	diego	diego	PROPN
admet-280	53	25	,	,	PUNCT
admet-280	53	26	ca)-coated	ca)-coate	VERB
admet-280	53	27	plates	plate	NOUN
admet-280	53	28	using	use	VERB
admet-280	53	29	mtesr	mtesr	NOUN
admet-280	53	30	™	™	PART
admet-280	53	31	1	1	NUM
admet-280	53	32	media	medium	NOUN
admet-280	53	33	(	(	PUNCT
admet-280	53	34	stem	stem	NOUN
admet-280	53	35	cell	cell	NOUN
admet-280	53	36	technologies	technology	NOUN
admet-280	53	37	,	,	PUNCT
admet-280	53	38	vancouver	vancouver	PROPN
admet-280	53	39	,	,	PUNCT
admet-280	53	40	canada	canada	PROPN
admet-280	53	41	)	)	PUNCT
admet-280	53	42	.	.	PUNCT
admet-280	54	1	hepatocyte	hepatocyte	NOUN
admet-280	54	2	differentiation	differentiation	NOUN
admet-280	54	3	was	be	AUX
admet-280	54	4	induced	induce	VERB
admet-280	54	5	in	in	ADP
admet-280	54	6	three	three	NUM
admet-280	54	7	stages	stage	NOUN
admet-280	54	8	,	,	PUNCT
admet-280	54	9	as	as	SCONJ
admet-280	54	10	published	publish	VERB
admet-280	54	11	by	by	ADP
admet-280	54	12	hay	hay	PROPN
admet-280	54	13	et	et	PROPN
admet-280	54	14	al	al	PROPN
admet-280	55	1	[	[	X
admet-280	55	2	11	11	NUM
admet-280	55	3	,	,	PUNCT
admet-280	55	4	12	12	NUM
admet-280	55	5	]	]	PUNCT
admet-280	55	6	.	.	PUNCT
admet-280	56	1	briefly	briefly	NOUN
admet-280	56	2	,	,	PUNCT
admet-280	56	3	differentiation	differentiation	NOUN
admet-280	56	4	was	be	AUX
admet-280	56	5	initiated	initiate	VERB
admet-280	56	6	at	at	ADP
admet-280	56	7	60	60	NUM
admet-280	56	8	-	-	SYM
admet-280	56	9	70	70	NUM
admet-280	56	10	%	%	NOUN
admet-280	56	11	confluence	confluence	NOUN
admet-280	56	12	by	by	ADP
admet-280	56	13	replacing	replace	VERB
admet-280	56	14	the	the	DET
admet-280	56	15	mtesr	mtesr	NOUN
admet-280	56	16	™	™	ADJ
admet-280	56	17	1	1	NUM
admet-280	56	18	media	medium	NOUN
admet-280	56	19	with	with	ADP
admet-280	56	20	priming	prime	VERB
admet-280	56	21	medium	medium	NOUN
admet-280	56	22	:	:	PUNCT
admet-280	56	23	rpmi	rpmi	NOUN
admet-280	56	24	1640	1640	NUM
admet-280	56	25	containing	contain	VERB
admet-280	56	26	1xb27	1xb27	PROPN
admet-280	56	27	(	(	PUNCT
admet-280	56	28	invitrogen	invitrogen	PROPN
admet-280	56	29	)	)	PUNCT
admet-280	56	30	,	,	PUNCT
admet-280	56	31	100	100	NUM
admet-280	56	32	ng	ng	NOUN
admet-280	56	33	/	/	SYM
admet-280	56	34	ml	ml	PROPN
admet-280	56	35	activin	activin	PROPN
admet-280	56	36	a	a	DET
admet-280	56	37	(	(	PUNCT
admet-280	56	38	peprotech	peprotech	NOUN
admet-280	56	39	,	,	PUNCT
admet-280	56	40	rocky	rocky	PROPN
admet-280	56	41	hill	hill	PROPN
admet-280	56	42	,	,	PUNCT
admet-280	56	43	nj	nj	PROPN
admet-280	56	44	)	)	PUNCT
admet-280	56	45	,	,	PUNCT
admet-280	56	46	and	and	CCONJ
admet-280	56	47	50	50	NUM
admet-280	56	48	ng	ng	NOUN
admet-280	56	49	/	/	SYM
admet-280	56	50	ml	ml	NOUN
admet-280	56	51	wnt3a	wnt3a	PROPN
admet-280	56	52	(	(	PUNCT
admet-280	56	53	r&d	r&d	NOUN
admet-280	56	54	systems	system	NOUN
admet-280	56	55	,	,	PUNCT
admet-280	56	56	minneapolis	minneapolis	PROPN
admet-280	56	57	,	,	PUNCT
admet-280	56	58	mn	mn	PROPN
admet-280	56	59	)	)	PUNCT
admet-280	56	60	.	.	PUNCT
admet-280	57	1	after	after	ADP
admet-280	57	2	72	72	NUM
admet-280	57	3	hours	hour	NOUN
admet-280	57	4	,	,	PUNCT
admet-280	57	5	with	with	ADP
admet-280	57	6	daily	daily	ADJ
admet-280	57	7	media	medium	NOUN
admet-280	57	8	changes	change	NOUN
admet-280	57	9	,	,	PUNCT
admet-280	57	10	the	the	DET
admet-280	57	11	cells	cell	NOUN
admet-280	57	12	were	be	AUX
admet-280	57	13	switched	switch	VERB
admet-280	57	14	to	to	ADP
admet-280	57	15	differentiation	differentiation	NOUN
admet-280	57	16	medium	medium	ADJ
admet-280	57	17	:	:	PUNCT
admet-280	57	18	knockout	knockout	NOUN
admet-280	57	19	-	-	PUNCT
admet-280	57	20	dmem	dmem	NOUN
admet-280	57	21	containing	contain	VERB
admet-280	57	22	20	20	NUM
admet-280	57	23	%	%	NOUN
admet-280	57	24	knockout	knockout	NOUN
admet-280	57	25	serum	serum	NOUN
admet-280	57	26	replacement	replacement	NOUN
admet-280	57	27	,	,	PUNCT
admet-280	57	28	1	1	NUM
admet-280	57	29	mm	mm	NOUN
admet-280	57	30	glutamine	glutamine	NOUN
admet-280	57	31	,	,	PUNCT
admet-280	57	32	1	1	NUM
admet-280	57	33	%	%	NOUN
admet-280	57	34	nonessential	nonessential	ADJ
admet-280	57	35	amino	amino	ADJ
admet-280	57	36	acids	acid	NOUN
admet-280	57	37	,	,	PUNCT
admet-280	57	38	0.1	0.1	NUM
admet-280	57	39	mm	mm	NOUN
admet-280	57	40	β	β	NOUN
admet-280	57	41	-	-	NOUN
admet-280	57	42	mercaptoethanol	mercaptoethanol	NOUN
admet-280	57	43	(	(	PUNCT
admet-280	57	44	invitrogen	invitrogen	PROPN
admet-280	57	45	)	)	PUNCT
admet-280	57	46	,	,	PUNCT
admet-280	57	47	and	and	CCONJ
admet-280	57	48	1	1	NUM
admet-280	57	49	%	%	NOUN
admet-280	57	50	dimethyl	dimethyl	NOUN
admet-280	57	51	sulfoxide	sulfoxide	NOUN
admet-280	57	52	(	(	PUNCT
admet-280	57	53	dmso	dmso	PROPN
admet-280	57	54	)	)	PUNCT
admet-280	57	55	(	(	PUNCT
admet-280	57	56	sigma	sigma	PROPN
admet-280	57	57	,	,	PUNCT
admet-280	57	58	st	st	PROPN
admet-280	57	59	louis	louis	PROPN
admet-280	57	60	,	,	PUNCT
admet-280	57	61	mo	mo	PROPN
admet-280	57	62	)	)	PUNCT
admet-280	57	63	for	for	ADP
admet-280	57	64	a	a	DET
admet-280	57	65	further	further	ADJ
admet-280	57	66	5	5	NUM
admet-280	57	67	days	day	NOUN
admet-280	57	68	.	.	PUNCT
admet-280	58	1	lastly	lastly	ADV
admet-280	58	2	,	,	PUNCT
admet-280	58	3	the	the	DET
admet-280	58	4	cells	cell	NOUN
admet-280	58	5	were	be	AUX
admet-280	58	6	switched	switch	VERB
admet-280	58	7	to	to	ADP
admet-280	58	8	maturation	maturation	NOUN
admet-280	58	9	media	medium	NOUN
admet-280	58	10	:	:	PUNCT
admet-280	58	11	hepatozyme	hepatozyme	VERB
admet-280	58	12	containing	contain	VERB
admet-280	58	13	10	10	NUM
admet-280	58	14	μm	μm	NUM
admet-280	58	15	hydrocortisone	hydrocortisone	NOUN
admet-280	58	16	21	21	NUM
admet-280	58	17	-	-	PUNCT
admet-280	58	18	hemisuccinate	hemisuccinate	NOUN
admet-280	58	19	,	,	PUNCT
admet-280	58	20	2	2	NUM
admet-280	58	21	mm	mm	NOUN
admet-280	58	22	glutamine	glutamine	NOUN
admet-280	58	23	,	,	PUNCT
admet-280	58	24	10	10	NUM
admet-280	58	25	ng	ng	NOUN
admet-280	58	26	/	/	SYM
admet-280	58	27	ml	ml	NOUN
admet-280	58	28	hepatocyte	hepatocyte	NOUN
admet-280	58	29	growth	growth	NOUN
admet-280	58	30	factor	factor	NOUN
admet-280	58	31	and	and	CCONJ
admet-280	58	32	20	20	NUM
admet-280	58	33	ng	ng	NOUN
admet-280	58	34	/	/	SYM
admet-280	58	35	ml	ml	X
admet-280	58	36	oncostatin	oncostatin	VERB
admet-280	58	37	m	m	PROPN
admet-280	58	38	(	(	PUNCT
admet-280	58	39	r&d	r&d	NOUN
admet-280	58	40	systems	system	NOUN
admet-280	58	41	)	)	PUNCT
admet-280	58	42	.	.	PUNCT
admet-280	59	1	the	the	DET
admet-280	59	2	media	medium	NOUN
admet-280	59	3	was	be	AUX
admet-280	59	4	changed	change	VERB
admet-280	59	5	every	every	DET
admet-280	59	6	other	other	ADJ
admet-280	59	7	day	day	NOUN
admet-280	59	8	during	during	ADP
admet-280	59	9	maturation	maturation	NOUN
admet-280	59	10	until	until	ADP
admet-280	59	11	the	the	DET
admet-280	59	12	end	end	NOUN
admet-280	59	13	of	of	ADP
admet-280	59	14	differentiation	differentiation	NOUN
admet-280	59	15	around	around	ADP
admet-280	59	16	day	day	NOUN
admet-280	59	17	17	17	NUM
admet-280	59	18	.	.	PUNCT
admet-280	60	1	to	to	PART
admet-280	60	2	investigate	investigate	VERB
admet-280	60	3	the	the	DET
admet-280	60	4	inductive	inductive	ADJ
admet-280	60	5	capacity	capacity	NOUN
admet-280	60	6	http://www.wicell.org/	http://www.wicell.org/	PRON
admet-280	60	7	admet	admet	PROPN
admet-280	60	8	&	&	CCONJ
admet-280	60	9	dmpk	dmpk	PROPN
admet-280	60	10	4(2	4(2	NUM
admet-280	60	11	)	)	PUNCT
admet-280	60	12	(	(	PUNCT
admet-280	60	13	2016	2016	NUM
admet-280	60	14	)	)	PUNCT
admet-280	60	15	62	62	NUM
admet-280	60	16	-	-	SYM
admet-280	60	17	83	83	NUM
admet-280	60	18	pharmacogenetics	pharmacogenetic	NOUN
admet-280	60	19	and	and	CCONJ
admet-280	60	20	cyp	cyp	ADJ
admet-280	60	21	activity	activity	NOUN
admet-280	60	22	doi	doi	NOUN
admet-280	60	23	:	:	PUNCT
admet-280	60	24	10.5599	10.5599	NUM
admet-280	60	25	/	/	SYM
admet-280	60	26	admet.4.2.280	admet.4.2.280	NOUN
admet-280	60	27	65	65	NUM
admet-280	60	28	of	of	ADP
admet-280	60	29	cyp	cyp	ADJ
admet-280	60	30	enzymes	enzyme	NOUN
admet-280	60	31	,	,	PUNCT
admet-280	60	32	cells	cell	NOUN
admet-280	60	33	were	be	AUX
admet-280	60	34	cultured	cultured	ADJ
admet-280	60	35	in	in	ADP
admet-280	60	36	the	the	DET
admet-280	60	37	presence	presence	NOUN
admet-280	60	38	of	of	ADP
admet-280	60	39	10	10	NUM
admet-280	60	40	μm	μm	NOUN
admet-280	60	41	rifampicin	rifampicin	NOUN
admet-280	60	42	(	(	PUNCT
admet-280	60	43	sigma	sigma	PROPN
admet-280	60	44	)	)	PUNCT
admet-280	60	45	,	,	PUNCT
admet-280	60	46	1	1	NUM
admet-280	60	47	mm	mm	NOUN
admet-280	60	48	phenobarbital	phenobarbital	NOUN
admet-280	60	49	(	(	PUNCT
admet-280	60	50	sigma	sigma	PROPN
admet-280	60	51	)	)	PUNCT
admet-280	60	52	,	,	PUNCT
admet-280	60	53	or	or	CCONJ
admet-280	60	54	0.1	0.1	NUM
admet-280	60	55	%	%	NOUN
admet-280	60	56	dmso	dmso	NOUN
admet-280	60	57	as	as	ADP
admet-280	60	58	a	a	DET
admet-280	60	59	vehicle	vehicle	NOUN
admet-280	60	60	control	control	NOUN
admet-280	60	61	for	for	ADP
admet-280	60	62	72	72	NUM
admet-280	60	63	hours	hour	NOUN
admet-280	60	64	before	before	ADP
admet-280	60	65	the	the	DET
admet-280	60	66	end	end	NOUN
admet-280	60	67	of	of	ADP
admet-280	60	68	differentiation	differentiation	NOUN
admet-280	60	69	on	on	ADP
admet-280	60	70	day	day	NOUN
admet-280	60	71	17	17	NUM
admet-280	60	72	.	.	PUNCT
admet-280	61	1	additional	additional	ADJ
admet-280	61	2	h9	h9	PROPN
admet-280	61	3	scdhs	scdhs	PROPN
admet-280	61	4	were	be	AUX
admet-280	61	5	a	a	DET
admet-280	61	6	kind	kind	ADJ
admet-280	61	7	gift	gift	NOUN
admet-280	61	8	from	from	ADP
admet-280	61	9	dr	dr	PROPN
admet-280	61	10	.	.	PROPN
admet-280	61	11	david	david	PROPN
admet-280	61	12	hay	hay	PROPN
admet-280	61	13	at	at	ADP
admet-280	61	14	the	the	DET
admet-280	61	15	university	university	PROPN
admet-280	61	16	of	of	ADP
admet-280	61	17	edinburgh	edinburgh	PROPN
admet-280	61	18	.	.	PUNCT
admet-280	62	1	scdhs	scdhs	PROPN
admet-280	62	2	used	use	VERB
admet-280	62	3	for	for	ADP
admet-280	62	4	the	the	DET
admet-280	62	5	cyp	cyp	ADJ
admet-280	62	6	cocktail	cocktail	NOUN
admet-280	62	7	assay	assay	NOUN
admet-280	62	8	were	be	AUX
admet-280	62	9	differentiated	differentiate	VERB
admet-280	62	10	using	use	VERB
admet-280	62	11	a	a	DET
admet-280	62	12	slightly	slightly	ADV
admet-280	62	13	different	different	ADJ
admet-280	62	14	method	method	NOUN
admet-280	62	15	.	.	PUNCT
admet-280	63	1	briefly	briefly	NOUN
admet-280	63	2	,	,	PUNCT
admet-280	63	3	hescs	hesc	NOUN
admet-280	63	4	were	be	AUX
admet-280	63	5	cultured	cultured	ADJ
admet-280	63	6	on	on	ADP
admet-280	63	7	matrigel	matrigel	NOUN
admet-280	63	8	™	™	ADJ
admet-280	63	9	plates	plate	NOUN
admet-280	63	10	using	use	VERB
admet-280	63	11	mtesr	mtesr	NOUN
admet-280	63	12	™	™	PART
admet-280	63	13	1	1	NUM
admet-280	63	14	media	medium	NOUN
admet-280	63	15	as	as	ADP
admet-280	63	16	above	above	ADV
admet-280	63	17	.	.	PUNCT
admet-280	64	1	prior	prior	ADV
admet-280	64	2	to	to	ADP
admet-280	64	3	the	the	DET
admet-280	64	4	start	start	NOUN
admet-280	64	5	of	of	ADP
admet-280	64	6	differentiation	differentiation	NOUN
admet-280	64	7	,	,	PUNCT
admet-280	64	8	cells	cell	NOUN
admet-280	64	9	were	be	AUX
admet-280	64	10	passaged	passage	VERB
admet-280	64	11	with	with	ADP
admet-280	64	12	0.05	0.05	NUM
admet-280	64	13	%	%	NOUN
admet-280	64	14	trypsin	trypsin	NOUN
admet-280	64	15	-	-	PUNCT
admet-280	64	16	edta	edta	NOUN
admet-280	64	17	(	(	PUNCT
admet-280	64	18	invitrogen	invitrogen	PROPN
admet-280	64	19	)	)	PUNCT
admet-280	64	20	to	to	ADP
admet-280	64	21	single	single	ADJ
admet-280	64	22	cells	cell	NOUN
admet-280	64	23	and	and	CCONJ
admet-280	64	24	1	1	NUM
admet-280	64	25	x	x	SYM
admet-280	64	26	105	105	NUM
admet-280	64	27	cells	cell	NOUN
admet-280	64	28	per	per	ADP
admet-280	64	29	well	well	ADV
admet-280	64	30	were	be	AUX
admet-280	64	31	plated	plate	VERB
admet-280	64	32	on	on	ADP
admet-280	64	33	fresh	fresh	ADJ
admet-280	64	34	matrigel	matrigel	NOUN
admet-280	64	35	™	™	VERB
admet-280	64	36	coated	coat	VERB
admet-280	64	37	24	24	NUM
admet-280	64	38	-	-	PUNCT
admet-280	64	39	well	well	NOUN
admet-280	64	40	plates	plate	NOUN
admet-280	64	41	in	in	ADP
admet-280	64	42	mtesr	mtesr	PROPN
admet-280	64	43	™	™	PART
admet-280	64	44	1	1	NUM
admet-280	64	45	media	medium	NOUN
admet-280	64	46	containing	contain	VERB
admet-280	64	47	10	10	NUM
admet-280	64	48	μm	μm	NOUN
admet-280	64	49	y27632	y27632	PROPN
admet-280	64	50	(	(	PUNCT
admet-280	64	51	rock	rock	NOUN
admet-280	64	52	inhibitor	inhibitor	NOUN
admet-280	64	53	)	)	PUNCT
admet-280	64	54	(	(	PUNCT
admet-280	64	55	selleck	selleck	PROPN
admet-280	64	56	chemicals	chemical	NOUN
admet-280	64	57	,	,	PUNCT
admet-280	64	58	houston	houston	PROPN
admet-280	64	59	,	,	PUNCT
admet-280	64	60	tx	tx	PROPN
admet-280	64	61	)	)	PUNCT
admet-280	64	62	.	.	PUNCT
admet-280	65	1	cells	cell	NOUN
admet-280	65	2	were	be	AUX
admet-280	65	3	cultured	cultured	ADJ
admet-280	65	4	in	in	ADP
admet-280	65	5	these	these	DET
admet-280	65	6	conditions	condition	NOUN
admet-280	65	7	for	for	ADP
admet-280	65	8	24	24	NUM
admet-280	65	9	hours	hour	NOUN
admet-280	65	10	and	and	CCONJ
admet-280	65	11	then	then	ADV
admet-280	65	12	differentiation	differentiation	NOUN
admet-280	65	13	was	be	AUX
admet-280	65	14	initiated	initiate	VERB
admet-280	65	15	with	with	ADP
admet-280	65	16	priming	prime	VERB
admet-280	65	17	medium	medium	NOUN
admet-280	65	18	as	as	SCONJ
admet-280	65	19	described	describe	VERB
admet-280	65	20	above	above	ADV
admet-280	65	21	.	.	PUNCT
admet-280	66	1	fetal	fetal	ADJ
admet-280	66	2	and	and	CCONJ
admet-280	66	3	adult	adult	NOUN
admet-280	66	4	liver	liver	NOUN
admet-280	66	5	tissue	tissue	NOUN
admet-280	66	6	six	six	NUM
admet-280	66	7	human	human	ADJ
admet-280	66	8	fetal	fetal	ADJ
admet-280	66	9	liver	liver	NOUN
admet-280	66	10	tissue	tissue	NOUN
admet-280	66	11	samples	sample	NOUN
admet-280	66	12	were	be	AUX
admet-280	66	13	obtained	obtain	VERB
admet-280	66	14	from	from	ADP
admet-280	66	15	the	the	DET
admet-280	66	16	birth	birth	NOUN
admet-280	66	17	defects	defect	NOUN
admet-280	66	18	research	research	NOUN
admet-280	66	19	laboratory	laboratory	NOUN
admet-280	66	20	at	at	ADP
admet-280	66	21	the	the	DET
admet-280	66	22	university	university	PROPN
admet-280	66	23	of	of	ADP
admet-280	66	24	washington	washington	PROPN
admet-280	66	25	,	,	PUNCT
admet-280	66	26	courtesy	courtesy	NOUN
admet-280	66	27	of	of	ADP
admet-280	66	28	dr	dr	PROPN
admet-280	66	29	.	.	PROPN
admet-280	66	30	qingcheng	qingcheng	PROPN
admet-280	66	31	mao	mao	PROPN
admet-280	66	32	.	.	PUNCT
admet-280	67	1	fetal	fetal	ADJ
admet-280	67	2	liver	liver	NOUN
admet-280	67	3	tissues	tissue	NOUN
admet-280	67	4	were	be	AUX
admet-280	67	5	obtained	obtain	VERB
admet-280	67	6	with	with	ADP
admet-280	67	7	use	use	NOUN
admet-280	67	8	of	of	ADP
admet-280	67	9	non	non	ADJ
admet-280	67	10	-	-	ADJ
admet-280	67	11	identifiable	identifiable	ADJ
admet-280	67	12	biological	biological	ADJ
admet-280	67	13	specimens	specimen	NOUN
admet-280	67	14	/	/	SYM
admet-280	67	15	data	datum	NOUN
admet-280	67	16	and	and	CCONJ
admet-280	67	17	so	so	ADV
admet-280	67	18	exempt	exempt	ADJ
admet-280	67	19	from	from	ADP
admet-280	67	20	human	human	ADJ
admet-280	67	21	subjects	subject	NOUN
admet-280	67	22	review	review	NOUN
admet-280	67	23	.	.	PUNCT
admet-280	68	1	human	human	ADJ
admet-280	68	2	liver	liver	NOUN
admet-280	68	3	tissue	tissue	NOUN
admet-280	68	4	samples	sample	NOUN
admet-280	68	5	were	be	AUX
admet-280	68	6	obtained	obtain	VERB
admet-280	68	7	from	from	ADP
admet-280	68	8	the	the	DET
admet-280	68	9	uw	uw	PROPN
admet-280	68	10	school	school	NOUN
admet-280	68	11	of	of	ADP
admet-280	68	12	pharmacy	pharmacy	NOUN
admet-280	68	13	human	human	ADJ
admet-280	68	14	liver	liver	NOUN
admet-280	68	15	bank	bank	PROPN
admet-280	68	16	(	(	PUNCT
admet-280	68	17	seattle	seattle	PROPN
admet-280	68	18	,	,	PUNCT
admet-280	68	19	wa	wa	PROPN
admet-280	68	20	)	)	PUNCT
admet-280	69	1	[	[	X
admet-280	69	2	13	13	NUM
admet-280	69	3	]	]	PUNCT
admet-280	69	4	.	.	PUNCT
admet-280	70	1	immunocytochemistry	immunocytochemistry	NOUN
admet-280	70	2	cells	cell	NOUN
admet-280	70	3	on	on	ADP
admet-280	70	4	day	day	NOUN
admet-280	70	5	17	17	NUM
admet-280	70	6	of	of	ADP
admet-280	70	7	differentiation	differentiation	NOUN
admet-280	70	8	were	be	AUX
admet-280	70	9	fixed	fix	VERB
admet-280	70	10	with	with	ADP
admet-280	70	11	ice	ice	NOUN
admet-280	70	12	-	-	PUNCT
admet-280	70	13	cold	cold	ADJ
admet-280	70	14	methanol	methanol	NOUN
admet-280	70	15	for	for	ADP
admet-280	70	16	10	10	NUM
admet-280	70	17	-	-	SYM
admet-280	70	18	15	15	NUM
admet-280	70	19	minutes	minute	NOUN
admet-280	70	20	,	,	PUNCT
admet-280	70	21	washed	wash	VERB
admet-280	70	22	with	with	ADP
admet-280	70	23	pbs	pbs	PROPN
admet-280	70	24	,	,	PUNCT
admet-280	70	25	and	and	CCONJ
admet-280	70	26	permeabilized	permeabilize	VERB
admet-280	70	27	with	with	ADP
admet-280	70	28	0.5	0.5	NUM
admet-280	70	29	%	%	NOUN
admet-280	70	30	triton	triton	PROPN
admet-280	70	31	x-100	x-100	PROPN
admet-280	70	32	for	for	ADP
admet-280	70	33	2	2	NUM
admet-280	70	34	minutes	minute	NOUN
admet-280	70	35	.	.	PUNCT
admet-280	71	1	following	follow	VERB
admet-280	71	2	a	a	DET
admet-280	71	3	pbs	pbs	PROPN
admet-280	71	4	wash	wash	NOUN
admet-280	71	5	,	,	PUNCT
admet-280	71	6	cells	cell	NOUN
admet-280	71	7	were	be	AUX
admet-280	71	8	blocked	block	VERB
admet-280	71	9	with	with	ADP
admet-280	71	10	2	2	NUM
admet-280	71	11	%	%	NOUN
admet-280	71	12	normal	normal	ADJ
admet-280	71	13	goat	goat	PROPN
admet-280	71	14	serum	serum	NOUN
admet-280	71	15	for	for	ADP
admet-280	71	16	1	1	NUM
admet-280	71	17	hour	hour	NOUN
admet-280	71	18	at	at	ADP
admet-280	71	19	room	room	NOUN
admet-280	71	20	temperature	temperature	NOUN
admet-280	71	21	.	.	PUNCT
admet-280	72	1	cells	cell	NOUN
admet-280	72	2	were	be	AUX
admet-280	72	3	then	then	ADV
admet-280	72	4	washed	wash	VERB
admet-280	72	5	with	with	ADP
admet-280	72	6	pbs	pbs	PROPN
admet-280	72	7	again	again	ADV
admet-280	72	8	and	and	CCONJ
admet-280	72	9	incubated	incubate	VERB
admet-280	72	10	overnight	overnight	ADV
admet-280	72	11	at	at	ADP
admet-280	72	12	4	4	NUM
admet-280	72	13	°	°	ADP
admet-280	72	14	c	c	NOUN
admet-280	72	15	with	with	ADP
admet-280	72	16	the	the	DET
admet-280	72	17	following	following	ADJ
admet-280	72	18	primary	primary	ADJ
admet-280	72	19	antibodies	antibody	NOUN
admet-280	72	20	:	:	PUNCT
admet-280	72	21	anti	anti	ADJ
admet-280	72	22	-	-	ADJ
admet-280	72	23	afp	afp	NOUN
admet-280	72	24	at	at	ADP
admet-280	72	25	1:600	1:600	NUM
admet-280	72	26	(	(	PUNCT
admet-280	72	27	dako	dako	PROPN
admet-280	72	28	,	,	PUNCT
admet-280	72	29	carpinteria	carpinteria	PROPN
admet-280	72	30	,	,	PUNCT
admet-280	72	31	ca	ca	NOUN
admet-280	72	32	)	)	PUNCT
admet-280	72	33	;	;	PUNCT
admet-280	72	34	antialbumin	antialbumin	NOUN
admet-280	72	35	at	at	ADP
admet-280	72	36	1:1000	1:1000	NUM
admet-280	72	37	(	(	PUNCT
admet-280	72	38	a	a	DET
admet-280	72	39	gift	gift	NOUN
admet-280	72	40	from	from	ADP
admet-280	72	41	dr	dr	PROPN
admet-280	72	42	.	.	PROPN
admet-280	72	43	jean	jean	PROPN
admet-280	72	44	campbell	campbell	PROPN
admet-280	72	45	,	,	PUNCT
admet-280	72	46	department	department	PROPN
admet-280	72	47	of	of	ADP
admet-280	72	48	pathology	pathology	PROPN
admet-280	72	49	,	,	PUNCT
admet-280	72	50	university	university	PROPN
admet-280	72	51	of	of	ADP
admet-280	72	52	washington	washington	PROPN
admet-280	72	53	)	)	PUNCT
admet-280	72	54	;	;	PUNCT
admet-280	72	55	anti	anti	ADJ
admet-280	72	56	-	-	ADJ
admet-280	72	57	hnf4α	hnf4α	ADJ
admet-280	72	58	at	at	ADP
admet-280	72	59	1:100	1:100	NUM
admet-280	72	60	(	(	PUNCT
admet-280	72	61	santa	santa	PROPN
admet-280	72	62	cruz	cruz	PROPN
admet-280	72	63	biotechnology	biotechnology	PROPN
admet-280	72	64	,	,	PUNCT
admet-280	72	65	dallas	dallas	PROPN
admet-280	72	66	,	,	PUNCT
admet-280	72	67	tx	tx	PROPN
admet-280	72	68	)	)	PUNCT
admet-280	72	69	;	;	PUNCT
admet-280	72	70	and	and	CCONJ
admet-280	72	71	anti	anti	NOUN
admet-280	72	72	-	-	ADJ
admet-280	72	73	cyp3a	cyp3a	NOUN
admet-280	72	74	at	at	ADP
admet-280	72	75	1:100	1:100	NUM
admet-280	72	76	(	(	PUNCT
admet-280	72	77	santa	santa	PROPN
admet-280	72	78	cruz	cruz	PROPN
admet-280	72	79	biotechnology	biotechnology	PROPN
admet-280	72	80	)	)	PUNCT
admet-280	72	81	.	.	PUNCT
admet-280	73	1	after	after	ADP
admet-280	73	2	washing	wash	VERB
admet-280	73	3	with	with	ADP
admet-280	73	4	pbs	pbs	PROPN
admet-280	73	5	,	,	PUNCT
admet-280	73	6	cells	cell	NOUN
admet-280	73	7	were	be	AUX
admet-280	73	8	incubated	incubate	VERB
admet-280	73	9	with	with	ADP
admet-280	73	10	alexa	alexa	NOUN
admet-280	73	11	fluor	fluor	NOUN
admet-280	73	12	®	®	NOUN
admet-280	73	13	488	488	NUM
admet-280	73	14	secondary	secondary	ADJ
admet-280	73	15	antibodies	antibody	NOUN
admet-280	73	16	at	at	ADP
admet-280	73	17	1:1000	1:1000	NUM
admet-280	73	18	for	for	ADP
admet-280	73	19	1	1	NUM
admet-280	73	20	hour	hour	NOUN
admet-280	73	21	at	at	ADP
admet-280	73	22	room	room	NOUN
admet-280	73	23	temperature	temperature	NOUN
admet-280	73	24	(	(	PUNCT
admet-280	73	25	invitrogen	invitrogen	PROPN
admet-280	73	26	)	)	PUNCT
admet-280	73	27	.	.	PUNCT
admet-280	74	1	finally	finally	ADV
admet-280	74	2	,	,	PUNCT
admet-280	74	3	cells	cell	NOUN
admet-280	74	4	were	be	AUX
admet-280	74	5	mounted	mount	VERB
admet-280	74	6	with	with	ADP
admet-280	74	7	slowfade	slowfade	ADJ
admet-280	74	8	®	®	NOUN
admet-280	74	9	gold	gold	NOUN
admet-280	74	10	antifade	antifade	PROPN
admet-280	74	11	mount	mount	PROPN
admet-280	74	12	with	with	ADP
admet-280	74	13	dapi	dapi	PROPN
admet-280	74	14	(	(	PUNCT
admet-280	74	15	invitrogen	invitrogen	PROPN
admet-280	74	16	)	)	PUNCT
admet-280	74	17	.	.	PUNCT
admet-280	75	1	dna	dna	PROPN
admet-280	75	2	isolation	isolation	NOUN
admet-280	75	3	and	and	CCONJ
admet-280	75	4	genotyping	genotype	VERB
admet-280	75	5	genomic	genomic	ADJ
admet-280	75	6	dna	dna	PROPN
admet-280	75	7	was	be	AUX
admet-280	75	8	isolated	isolate	VERB
admet-280	75	9	from	from	ADP
admet-280	75	10	the	the	DET
admet-280	75	11	wicell	wicell	PROPN
admet-280	75	12	®	®	NOUN
admet-280	75	13	hesc	hesc	NOUN
admet-280	75	14	lines	line	NOUN
admet-280	75	15	using	use	VERB
admet-280	75	16	the	the	DET
admet-280	75	17	qiagen	qiagen	NOUN
admet-280	75	18	(	(	PUNCT
admet-280	75	19	valencia	valencia	PROPN
admet-280	75	20	,	,	PUNCT
admet-280	75	21	california	california	PROPN
admet-280	75	22	)	)	PUNCT
admet-280	75	23	dneasy	dneasy	NOUN
admet-280	75	24	blood	blood	NOUN
admet-280	75	25	and	and	CCONJ
admet-280	75	26	tissue	tissue	NOUN
admet-280	75	27	kit	kit	NOUN
admet-280	75	28	according	accord	VERB
admet-280	75	29	to	to	ADP
admet-280	75	30	the	the	DET
admet-280	75	31	manufacturer	manufacturer	NOUN
admet-280	75	32	’s	’s	PART
admet-280	75	33	recommendations	recommendation	NOUN
admet-280	75	34	.	.	PUNCT
admet-280	76	1	dna	dna	PROPN
admet-280	76	2	was	be	AUX
admet-280	76	3	quantified	quantify	VERB
admet-280	76	4	on	on	ADP
admet-280	76	5	a	a	DET
admet-280	76	6	biorad	biorad	ADJ
admet-280	76	7	smartspec	smartspec	NOUN
admet-280	76	8	plus	plus	CCONJ
admet-280	76	9	(	(	PUNCT
admet-280	76	10	hercules	hercules	PROPN
admet-280	76	11	,	,	PUNCT
admet-280	76	12	ca	ca	NOUN
admet-280	76	13	)	)	PUNCT
admet-280	76	14	spectrophotometer	spectrophotometer	NOUN
admet-280	76	15	,	,	PUNCT
admet-280	76	16	measuring	measure	VERB
admet-280	76	17	absorbance	absorbance	NOUN
admet-280	76	18	and	and	CCONJ
admet-280	76	19	260/280	260/280	NUM
admet-280	76	20	nm	nm	ADJ
admet-280	76	21	ratio	ratio	NOUN
admet-280	76	22	.	.	PUNCT
admet-280	77	1	genotyping	genotyping	NOUN
admet-280	77	2	of	of	ADP
admet-280	77	3	hesc	hesc	PROPN
admet-280	77	4	lines	lines	PROPN
admet-280	77	5	h1	h1	PROPN
admet-280	77	6	,	,	PUNCT
admet-280	77	7	h7	h7	PROPN
admet-280	77	8	,	,	PUNCT
admet-280	77	9	h9	h9	NOUN
admet-280	77	10	,	,	PUNCT
admet-280	77	11	h13	h13	NOUN
admet-280	77	12	,	,	PUNCT
admet-280	77	13	and	and	CCONJ
admet-280	77	14	h14	h14	NOUN
admet-280	77	15	was	be	AUX
admet-280	77	16	conducted	conduct	VERB
admet-280	77	17	using	use	VERB
admet-280	77	18	the	the	DET
admet-280	77	19	affymetrix	affymetrix	ADJ
admet-280	77	20	dmet	dmet	NOUN
admet-280	77	21	™	™	NOUN
admet-280	77	22	plus	plus	CCONJ
admet-280	77	23	array	array	VERB
admet-280	77	24	according	accord	VERB
admet-280	77	25	to	to	ADP
admet-280	77	26	manufacturer	manufacturer	NOUN
admet-280	77	27	’s	’s	PART
admet-280	77	28	recommendations	recommendation	NOUN
admet-280	77	29	(	(	PUNCT
admet-280	77	30	santa	santa	PROPN
admet-280	77	31	clara	clara	PROPN
admet-280	77	32	,	,	PUNCT
admet-280	77	33	ca	ca	PROPN
admet-280	77	34	,	,	PUNCT
admet-280	77	35	http://www.affymetrix.com	http://www.affymetrix.com	PROPN
admet-280	77	36	)	)	PUNCT
admet-280	77	37	.	.	PUNCT
admet-280	78	1	analysis	analysis	NOUN
admet-280	78	2	was	be	AUX
admet-280	78	3	performed	perform	VERB
admet-280	78	4	using	use	VERB
admet-280	78	5	affymetrix	affymetrix	NOUN
admet-280	78	6	’s	’s	PART
admet-280	78	7	dmet	dmet	NOUN
admet-280	78	8	™	™	ADJ
admet-280	78	9	console	console	NOUN
admet-280	78	10	analysis	analysis	NOUN
admet-280	78	11	software	software	NOUN
admet-280	78	12	.	.	PUNCT
admet-280	79	1	quantitative	quantitative	ADJ
admet-280	79	2	real	real	ADJ
admet-280	79	3	-	-	PUNCT
admet-280	79	4	time	time	NOUN
admet-280	79	5	pcr	pcr	NOUN
admet-280	79	6	(	(	PUNCT
admet-280	79	7	qrt	qrt	NOUN
admet-280	79	8	-	-	PUNCT
admet-280	79	9	pcr	pcr	NOUN
admet-280	79	10	)	)	PUNCT
admet-280	79	11	and	and	CCONJ
admet-280	79	12	cyp2d6	cyp2d6	NOUN
admet-280	79	13	copy	copy	NOUN
admet-280	79	14	number	number	NOUN
admet-280	79	15	assay	assay	PROPN
admet-280	79	16	rna	rna	PROPN
admet-280	79	17	was	be	AUX
admet-280	79	18	isolated	isolate	VERB
admet-280	79	19	using	use	VERB
admet-280	79	20	trizol	trizol	PROPN
admet-280	79	21	reagent	reagent	NOUN
admet-280	79	22	from	from	ADP
admet-280	79	23	invitrogen	invitrogen	PROPN
admet-280	79	24	(	(	PUNCT
admet-280	79	25	carlsbad	carlsbad	PROPN
admet-280	79	26	,	,	PUNCT
admet-280	79	27	ca	ca	NOUN
admet-280	79	28	)	)	PUNCT
admet-280	79	29	following	follow	VERB
admet-280	79	30	manufacturer	manufacturer	NOUN
admet-280	79	31	’s	’s	PART
admet-280	79	32	recommendations	recommendation	NOUN
admet-280	79	33	,	,	PUNCT
admet-280	79	34	and	and	CCONJ
admet-280	79	35	quantified	quantify	VERB
admet-280	79	36	on	on	ADP
admet-280	79	37	a	a	DET
admet-280	79	38	biorad	biorad	ADJ
admet-280	79	39	smartspec	smartspec	NOUN
admet-280	79	40	plus	plus	CCONJ
admet-280	79	41	(	(	PUNCT
admet-280	79	42	hercules	hercules	PROPN
admet-280	79	43	,	,	PUNCT
admet-280	79	44	ca	ca	NOUN
admet-280	79	45	)	)	PUNCT
admet-280	79	46	spectrophotometer	spectrophotometer	NOUN
admet-280	79	47	,	,	PUNCT
admet-280	79	48	measuring	measure	VERB
admet-280	79	49	absorbance	absorbance	NOUN
admet-280	79	50	and	and	CCONJ
admet-280	79	51	260/280	260/280	NUM
admet-280	79	52	nm	nm	ADJ
admet-280	79	53	ratio	ratio	NOUN
admet-280	79	54	.	.	PUNCT
admet-280	80	1	complementary	complementary	ADJ
admet-280	80	2	dna	dna	PROPN
admet-280	80	3	(	(	PUNCT
admet-280	80	4	cdna	cdna	PROPN
admet-280	80	5	)	)	PUNCT
admet-280	80	6	was	be	AUX
admet-280	80	7	synthesized	synthesize	VERB
admet-280	80	8	using	use	VERB
admet-280	80	9	1	1	NUM
admet-280	80	10	μg	μg	PROPN
admet-280	80	11	total	total	PROPN
admet-280	80	12	rna	rna	PROPN
admet-280	80	13	and	and	CCONJ
admet-280	80	14	the	the	DET
admet-280	80	15	taqman	taqman	NOUN
admet-280	80	16	®	®	NOUN
admet-280	80	17	reverse	reverse	VERB
admet-280	80	18	transcription	transcription	NOUN
admet-280	80	19	reagents	reagent	NOUN
admet-280	80	20	in	in	ADP
admet-280	80	21	10	10	NUM
admet-280	80	22	μl	μl	INTJ
admet-280	80	23	total	total	ADJ
admet-280	80	24	volume	volume	NOUN
admet-280	80	25	(	(	PUNCT
admet-280	80	26	invitrogen	invitrogen	PROPN
admet-280	80	27	)	)	PUNCT
admet-280	80	28	.	.	PUNCT
admet-280	81	1	following	follow	VERB
admet-280	81	2	synthesis	synthesis	NOUN
admet-280	81	3	,	,	PUNCT
admet-280	81	4	cdna	cdna	PROPN
admet-280	81	5	was	be	AUX
admet-280	81	6	diluted	dilute	VERB
admet-280	81	7	to	to	ADP
admet-280	81	8	5	5	NUM
admet-280	81	9	ng	ng	PROPN
admet-280	81	10	/	/	SYM
admet-280	81	11	μl	μl	PROPN
admet-280	81	12	and	and	CCONJ
admet-280	81	13	20	20	NUM
admet-280	81	14	ng	ng	PROPN
admet-280	81	15	was	be	AUX
admet-280	81	16	used	use	VERB
admet-280	81	17	for	for	ADP
admet-280	81	18	qrt	qrt	ADJ
admet-280	81	19	-	-	PUNCT
admet-280	81	20	pcr	pcr	ADJ
admet-280	81	21	analysis	analysis	NOUN
admet-280	81	22	.	.	PUNCT
admet-280	82	1	qrt	qrt	NOUN
admet-280	82	2	-	-	PUNCT
admet-280	82	3	pcr	pcr	PROPN
admet-280	82	4	for	for	ADP
admet-280	82	5	cyps	cyps	PROPN
admet-280	82	6	3a4	3a4	NUM
admet-280	82	7	,	,	PUNCT
admet-280	82	8	3a7	3a7	NUM
admet-280	82	9	,	,	PUNCT
admet-280	82	10	1a2	1a2	NUM
admet-280	82	11	,	,	PUNCT
admet-280	82	12	1b1	1b1	NUM
admet-280	82	13	,	,	PUNCT
admet-280	82	14	2a6	2a6	NUM
admet-280	82	15	,	,	PUNCT
admet-280	82	16	2b6	2b6	NUM
admet-280	82	17	,	,	PUNCT
admet-280	82	18	2c9	2c9	NUM
admet-280	82	19	,	,	PUNCT
admet-280	82	20	2c19	2c19	NOUN
admet-280	82	21	,	,	PUNCT
admet-280	82	22	2c8	2c8	NUM
admet-280	82	23	,	,	PUNCT
admet-280	82	24	2d6	2d6	NUM
admet-280	82	25	,	,	PUNCT
admet-280	82	26	2e1	2e1	NUM
admet-280	82	27	,	,	PUNCT
admet-280	82	28	fmo1	fmo1	NOUN
admet-280	82	29	,	,	PUNCT
admet-280	82	30	fmo3	fmo3	NOUN
admet-280	82	31	,	,	PUNCT
admet-280	82	32	ugt1a1	ugt1a1	PROPN
admet-280	82	33	,	,	PUNCT
admet-280	82	34	ugt1a6	ugt1a6	NOUN
admet-280	82	35	,	,	PUNCT
admet-280	82	36	ugt2b4	ugt2b4	NOUN
admet-280	82	37	,	,	PUNCT
admet-280	82	38	ugt2b7	ugt2b7	NOUN
admet-280	82	39	,	,	PUNCT
admet-280	82	40	gstt1	gstt1	NOUN
admet-280	82	41	,	,	PUNCT
admet-280	82	42	gstm1	gstm1	PROPN
admet-280	82	43	,	,	PUNCT
admet-280	82	44	gstp1	gstp1	NOUN
admet-280	82	45	,	,	PUNCT
admet-280	82	46	oatp1b1	oatp1b1	NUM
admet-280	82	47	,	,	PUNCT
admet-280	82	48	oatp1b3	oatp1b3	PROPN
admet-280	82	49	,	,	PUNCT
admet-280	82	50	mrp2	mrp2	PROPN
admet-280	82	51	,	,	PUNCT
admet-280	82	52	abcb1	abcb1	NOUN
admet-280	82	53	,	,	PUNCT
admet-280	82	54	abcg2	abcg2	NOUN
admet-280	82	55	,	,	PUNCT
admet-280	82	56	atp7b	atp7b	PROPN
admet-280	82	57	,	,	PUNCT
admet-280	82	58	nanog	nanog	PROPN
admet-280	82	59	,	,	PUNCT
admet-280	82	60	sox2	sox2	NOUN
admet-280	82	61	,	,	PUNCT
admet-280	82	62	oct4	oct4	PROPN
admet-280	82	63	,	,	PUNCT
admet-280	82	64	alb	alb	PROPN
admet-280	82	65	,	,	PUNCT
admet-280	82	66	afp	afp	NOUN
admet-280	82	67	,	,	PUNCT
admet-280	82	68	hnf4α	hnf4α	PROPN
admet-280	82	69	,	,	PUNCT
admet-280	82	70	car	car	NOUN
admet-280	82	71	,	,	PUNCT
admet-280	82	72	pxr	pxr	PROPN
admet-280	82	73	,	,	PUNCT
admet-280	82	74	ahr	ahr	PROPN
admet-280	82	75	,	,	PUNCT
admet-280	82	76	and	and	CCONJ
admet-280	82	77	por	por	NOUN
admet-280	82	78	was	be	AUX
admet-280	82	79	carried	carry	VERB
admet-280	82	80	out	out	ADP
admet-280	82	81	using	use	VERB
admet-280	82	82	taqman	taqman	NOUN
admet-280	82	83	®	®	NOUN
admet-280	82	84	gene	gene	NOUN
admet-280	82	85	expression	expression	NOUN
admet-280	82	86	assays	assay	NOUN
admet-280	82	87	from	from	ADP
admet-280	82	88	applied	apply	VERB
admet-280	82	89	biosystems	biosystem	NOUN
admet-280	82	90	(	(	PUNCT
admet-280	82	91	foster	foster	ADJ
admet-280	82	92	city	city	NOUN
admet-280	82	93	,	,	PUNCT
admet-280	82	94	california	california	PROPN
admet-280	82	95	)	)	PUNCT
admet-280	82	96	with	with	ADP
admet-280	82	97	gusb	gusb	PROPN
admet-280	82	98	as	as	ADP
admet-280	82	99	the	the	DET
admet-280	82	100	housekeeping	housekeeping	NOUN
admet-280	82	101	gene	gene	NOUN
admet-280	82	102	.	.	PUNCT
admet-280	83	1	cyp2d6	cyp2d6	NOUN
admet-280	83	2	copy	copy	NOUN
admet-280	83	3	number	number	NOUN
admet-280	83	4	was	be	AUX
admet-280	83	5	voellinger	voellinger	NOUN
admet-280	83	6	and	and	CCONJ
admet-280	83	7	kelly	kelly	PROPN
admet-280	83	8	admet	admet	PROPN
admet-280	83	9	&	&	CCONJ
admet-280	83	10	dmpk	dmpk	PROPN
admet-280	83	11	4(2	4(2	NUM
admet-280	83	12	)	)	PUNCT
admet-280	83	13	(	(	PUNCT
admet-280	83	14	2016	2016	NUM
admet-280	83	15	)	)	PUNCT
admet-280	83	16	62	62	NUM
admet-280	83	17	-	-	SYM
admet-280	83	18	83	83	NUM
admet-280	83	19	66	66	NUM
admet-280	83	20	assessed	assess	VERB
admet-280	83	21	using	use	VERB
admet-280	83	22	a	a	DET
admet-280	83	23	taqman	taqman	NOUN
admet-280	83	24	®	®	NOUN
admet-280	83	25	copy	copy	NOUN
admet-280	83	26	number	number	NOUN
admet-280	83	27	assay	assay	VERB
admet-280	83	28	from	from	ADP
admet-280	83	29	applied	apply	VERB
admet-280	83	30	biosystems	biosystem	NOUN
admet-280	83	31	(	(	PUNCT
admet-280	83	32	hs00010001_cn	hs00010001_cn	PROPN
admet-280	83	33	)	)	PUNCT
admet-280	83	34	with	with	ADP
admet-280	83	35	rnasep	rnasep	NOUN
admet-280	83	36	as	as	ADP
admet-280	83	37	a	a	DET
admet-280	83	38	single	single	ADJ
admet-280	83	39	copy	copy	NOUN
admet-280	83	40	gene	gene	NOUN
admet-280	83	41	calibrator	calibrator	NOUN
admet-280	83	42	,	,	PUNCT
admet-280	83	43	according	accord	VERB
admet-280	83	44	to	to	ADP
admet-280	83	45	the	the	DET
admet-280	83	46	manufacturer	manufacturer	NOUN
admet-280	83	47	’s	’s	PART
admet-280	83	48	recommendations	recommendation	NOUN
admet-280	83	49	,	,	PUNCT
admet-280	83	50	using	use	VERB
admet-280	83	51	their	their	PRON
admet-280	83	52	sds	sds	NOUN
admet-280	83	53	2.3	2.3	NUM
admet-280	83	54	and	and	CCONJ
admet-280	83	55	copy	copy	VERB
admet-280	83	56	caller	caller	NOUN
admet-280	83	57	v1.0	v1.0	PROPN
admet-280	83	58	programs	program	NOUN
admet-280	83	59	.	.	PUNCT
admet-280	84	1	one	one	NUM
admet-280	84	2	copy	copy	NOUN
admet-280	84	3	and	and	CCONJ
admet-280	84	4	more	more	ADJ
admet-280	84	5	than	than	ADP
admet-280	84	6	two	two	NUM
admet-280	84	7	copy	copy	VERB
admet-280	84	8	positive	positive	ADJ
admet-280	84	9	controls	control	NOUN
admet-280	84	10	were	be	AUX
admet-280	84	11	identified	identify	VERB
admet-280	84	12	in	in	ADP
admet-280	84	13	the	the	DET
admet-280	84	14	uw	uw	PROPN
admet-280	84	15	school	school	NOUN
admet-280	84	16	of	of	ADP
admet-280	84	17	pharmacy	pharmacy	NOUN
admet-280	84	18	human	human	ADJ
admet-280	84	19	liver	liver	NOUN
admet-280	84	20	bank	bank	PROPN
admet-280	84	21	(	(	PUNCT
admet-280	84	22	seattle	seattle	PROPN
admet-280	84	23	,	,	PUNCT
admet-280	84	24	wa	wa	PROPN
admet-280	84	25	)	)	PUNCT
admet-280	84	26	through	through	ADP
admet-280	84	27	sequencing	sequence	VERB
admet-280	84	28	analysis	analysis	NOUN
admet-280	84	29	as	as	SCONJ
admet-280	84	30	previously	previously	ADV
admet-280	84	31	described	describe	VERB
admet-280	84	32	.	.	PUNCT
admet-280	85	1	cyp2d6	cyp2d6	NOUN
admet-280	85	2	*	*	SYM
admet-280	85	3	41	41	NUM
admet-280	85	4	reverse	reverse	NOUN
admet-280	85	5	-	-	PUNCT
admet-280	85	6	transcription	transcription	NOUN
admet-280	85	7	pcr	pcr	NOUN
admet-280	85	8	assay	assay	PROPN
admet-280	85	9	total	total	PROPN
admet-280	85	10	rna	rna	PROPN
admet-280	85	11	was	be	AUX
admet-280	85	12	isolated	isolate	VERB
admet-280	85	13	using	use	VERB
admet-280	85	14	trizol	trizol	ADJ
admet-280	85	15	reagent	reagent	NOUN
admet-280	85	16	(	(	PUNCT
admet-280	85	17	invitrogen	invitrogen	PROPN
admet-280	85	18	)	)	PUNCT
admet-280	85	19	,	,	PUNCT
admet-280	85	20	following	follow	VERB
admet-280	85	21	manufacturer	manufacturer	NOUN
admet-280	85	22	’s	’s	PART
admet-280	85	23	recommendations	recommendation	NOUN
admet-280	85	24	,	,	PUNCT
admet-280	85	25	and	and	CCONJ
admet-280	85	26	quantified	quantify	VERB
admet-280	85	27	on	on	ADP
admet-280	85	28	a	a	DET
admet-280	85	29	biorad	biorad	ADJ
admet-280	85	30	smartspec	smartspec	NOUN
admet-280	85	31	plus	plus	CCONJ
admet-280	85	32	(	(	PUNCT
admet-280	85	33	hercules	hercules	PROPN
admet-280	85	34	,	,	PUNCT
admet-280	85	35	ca	ca	NOUN
admet-280	85	36	)	)	PUNCT
admet-280	85	37	spectrophotometer	spectrophotometer	NOUN
admet-280	85	38	,	,	PUNCT
admet-280	85	39	measuring	measure	VERB
admet-280	85	40	absorbance	absorbance	NOUN
admet-280	85	41	and	and	CCONJ
admet-280	85	42	260/280	260/280	NUM
admet-280	85	43	nm	nm	ADJ
admet-280	85	44	ratio	ratio	NOUN
admet-280	85	45	.	.	PUNCT
admet-280	86	1	cdna	cdna	PROPN
admet-280	86	2	was	be	AUX
admet-280	86	3	synthesized	synthesize	VERB
admet-280	86	4	using	use	VERB
admet-280	86	5	the	the	DET
admet-280	86	6	taqman	taqman	NOUN
admet-280	86	7	reverse	reverse	NOUN
admet-280	86	8	transcription	transcription	NOUN
admet-280	86	9	kit	kit	NOUN
admet-280	86	10	(	(	PUNCT
admet-280	86	11	invitrogen	invitrogen	PROPN
admet-280	86	12	)	)	PUNCT
admet-280	86	13	from	from	ADP
admet-280	86	14	1	1	NUM
admet-280	86	15	μg	μg	NOUN
admet-280	86	16	of	of	ADP
admet-280	86	17	total	total	ADJ
admet-280	86	18	rna	rna	PROPN
admet-280	86	19	.	.	PUNCT
admet-280	87	1	to	to	PART
admet-280	87	2	detect	detect	VERB
admet-280	87	3	the	the	DET
admet-280	87	4	presence	presence	NOUN
admet-280	87	5	of	of	ADP
admet-280	87	6	exon	exon	NOUN
admet-280	87	7	6	6	NUM
admet-280	87	8	in	in	ADP
admet-280	87	9	cyp2d6	cyp2d6	NOUN
admet-280	87	10	,	,	PUNCT
admet-280	87	11	a	a	DET
admet-280	87	12	579	579	NUM
admet-280	87	13	-	-	PUNCT
admet-280	87	14	bp	bp	NOUN
admet-280	87	15	pcr	pcr	ADJ
admet-280	87	16	fragment	fragment	NOUN
admet-280	87	17	spanning	span	VERB
admet-280	87	18	a	a	DET
admet-280	87	19	region	region	NOUN
admet-280	87	20	from	from	ADP
admet-280	87	21	exon	exon	NOUN
admet-280	87	22	5	5	NUM
admet-280	87	23	to	to	PART
admet-280	87	24	exon	exon	NOUN
admet-280	87	25	8	8	NUM
admet-280	87	26	was	be	AUX
admet-280	87	27	amplified	amplify	VERB
admet-280	87	28	with	with	ADP
admet-280	87	29	primers	primer	NOUN
admet-280	87	30	exon5/8for3	exon5/8for3	X
admet-280	88	1	(	(	PUNCT
admet-280	88	2	5’-tccccgtcctcctgcata-3	5’-tccccgtcctcctgcata-3	NUM
admet-280	88	3	’	'	PUNCT
admet-280	88	4	)	)	PUNCT
admet-280	88	5	and	and	CCONJ
admet-280	88	6	exon5/8rev3	exon5/8rev3	X
admet-280	88	7	(	(	PUNCT
admet-280	88	8	5’-gtgttcggggtggaagcg-3	5’-gtgttcggggtggaagcg-3	NUM
admet-280	88	9	’	'	PUNCT
admet-280	88	10	)	)	PUNCT
admet-280	88	11	(	(	PUNCT
admet-280	88	12	idt	idt	PROPN
admet-280	88	13	,	,	PUNCT
admet-280	88	14	coralville	coralville	NOUN
admet-280	88	15	,	,	PUNCT
admet-280	88	16	iowa	iowa	PROPN
admet-280	88	17	)	)	PUNCT
admet-280	88	18	.	.	PUNCT
admet-280	89	1	if	if	SCONJ
admet-280	89	2	exon	exon	NOUN
admet-280	89	3	6	6	NUM
admet-280	89	4	is	be	AUX
admet-280	89	5	skipped	skip	VERB
admet-280	89	6	due	due	ADJ
admet-280	89	7	to	to	ADP
admet-280	89	8	the	the	DET
admet-280	89	9	presence	presence	NOUN
admet-280	89	10	of	of	ADP
admet-280	89	11	cyp2d6	cyp2d6	PROPN
admet-280	89	12	*	*	SYM
admet-280	89	13	41	41	NUM
admet-280	89	14	,	,	PUNCT
admet-280	89	15	a	a	DET
admet-280	89	16	smaller	small	ADJ
admet-280	89	17	pcr	pcr	ADJ
admet-280	89	18	fragment	fragment	NOUN
admet-280	89	19	of	of	ADP
admet-280	89	20	438	438	NUM
admet-280	89	21	-	-	PUNCT
admet-280	89	22	bp	bp	PROPN
admet-280	89	23	is	be	AUX
admet-280	89	24	expected	expect	VERB
admet-280	89	25	.	.	PUNCT
admet-280	90	1	pcr	pcr	PROPN
admet-280	90	2	was	be	AUX
admet-280	90	3	run	run	VERB
admet-280	90	4	under	under	ADP
admet-280	90	5	the	the	DET
admet-280	90	6	following	following	ADJ
admet-280	90	7	conditions	condition	NOUN
admet-280	90	8	,	,	PUNCT
admet-280	90	9	95	95	NUM
admet-280	90	10	°	°	NUM
admet-280	90	11	c	c	NOUN
admet-280	90	12	for	for	ADP
admet-280	90	13	5	5	NUM
admet-280	90	14	minutes	minute	NOUN
admet-280	90	15	,	,	PUNCT
admet-280	90	16	92	92	NUM
admet-280	90	17	°	°	NUM
admet-280	90	18	c	c	NOUN
admet-280	90	19	for	for	ADP
admet-280	90	20	20	20	NUM
admet-280	90	21	seconds	second	NOUN
admet-280	90	22	,	,	PUNCT
admet-280	90	23	59.6	59.6	NUM
admet-280	90	24	°	°	NOUN
admet-280	90	25	c	c	NOUN
admet-280	90	26	for	for	ADP
admet-280	90	27	30	30	NUM
admet-280	90	28	seconds	second	NOUN
admet-280	90	29	,	,	PUNCT
admet-280	90	30	72	72	NUM
admet-280	90	31	°	°	NUM
admet-280	90	32	c	c	NOUN
admet-280	90	33	for	for	ADP
admet-280	90	34	2	2	NUM
admet-280	90	35	minutes	minute	NOUN
admet-280	90	36	,	,	PUNCT
admet-280	90	37	72	72	NUM
admet-280	90	38	°	°	NUM
admet-280	90	39	c	c	NOUN
admet-280	90	40	for	for	ADP
admet-280	90	41	10	10	NUM
admet-280	90	42	minutes	minute	NOUN
admet-280	90	43	,	,	PUNCT
admet-280	90	44	4	4	NUM
admet-280	90	45	°	°	ADP
admet-280	90	46	c	c	NOUN
admet-280	90	47	hold	hold	NOUN
admet-280	90	48	,	,	PUNCT
admet-280	90	49	repeating	repeat	VERB
admet-280	90	50	steps	step	NOUN
admet-280	90	51	2	2	NUM
admet-280	90	52	-	-	SYM
admet-280	90	53	4	4	NUM
admet-280	90	54	for	for	ADP
admet-280	90	55	40	40	NUM
admet-280	90	56	cycles	cycle	NOUN
admet-280	90	57	.	.	PUNCT
admet-280	91	1	pcr	pcr	ADJ
admet-280	91	2	products	product	NOUN
admet-280	91	3	were	be	AUX
admet-280	91	4	run	run	VERB
admet-280	91	5	on	on	ADP
admet-280	91	6	1.5	1.5	NUM
admet-280	91	7	%	%	NOUN
admet-280	91	8	agarose	agarose	NOUN
admet-280	91	9	gels	gel	NOUN
admet-280	91	10	and	and	CCONJ
admet-280	91	11	visualized	visualize	VERB
admet-280	91	12	by	by	ADP
admet-280	91	13	staining	stain	VERB
admet-280	91	14	with	with	ADP
admet-280	91	15	0.5	0.5	NUM
admet-280	91	16	μg	μg	NOUN
admet-280	91	17	/	/	SYM
admet-280	91	18	ml	ml	NOUN
admet-280	91	19	ethidium	ethidium	NOUN
admet-280	91	20	bromide	bromide	NOUN
admet-280	91	21	(	(	PUNCT
admet-280	91	22	biorad	biorad	NOUN
admet-280	91	23	)	)	PUNCT
admet-280	91	24	.	.	PUNCT
admet-280	92	1	human	human	ADJ
admet-280	92	2	liver	liver	NOUN
admet-280	92	3	samples	sample	NOUN
admet-280	92	4	used	use	VERB
admet-280	92	5	for	for	ADP
admet-280	92	6	this	this	DET
admet-280	92	7	study	study	NOUN
admet-280	92	8	were	be	AUX
admet-280	92	9	obtained	obtain	VERB
admet-280	92	10	from	from	ADP
admet-280	92	11	the	the	DET
admet-280	92	12	uw	uw	PROPN
admet-280	92	13	school	school	NOUN
admet-280	92	14	of	of	ADP
admet-280	92	15	pharmacy	pharmacy	NOUN
admet-280	92	16	human	human	ADJ
admet-280	92	17	liver	liver	NOUN
admet-280	92	18	bank	bank	NOUN
admet-280	92	19	.	.	PUNCT
admet-280	93	1	genotyping	genotype	VERB
admet-280	93	2	for	for	ADP
admet-280	93	3	cyp2d6	cyp2d6	NOUN
admet-280	93	4	*	*	SYM
admet-280	93	5	41	41	NUM
admet-280	93	6	was	be	AUX
admet-280	93	7	done	do	VERB
admet-280	93	8	using	use	VERB
admet-280	93	9	an	an	DET
admet-280	93	10	existing	exist	VERB
admet-280	93	11	taqman	taqman	NOUN
admet-280	93	12	®	®	NOUN
admet-280	93	13	assay	assay	NOUN
admet-280	93	14	(	(	PUNCT
admet-280	93	15	c_34816116	c_34816116	PROPN
admet-280	93	16	)	)	PUNCT
admet-280	93	17	(	(	PUNCT
admet-280	93	18	applied	apply	VERB
admet-280	93	19	biosystems	biosystem	NOUN
admet-280	93	20	)	)	PUNCT
admet-280	93	21	.	.	PUNCT
admet-280	94	1	cyp	cyp	ADJ
admet-280	94	2	cocktail	cocktail	NOUN
admet-280	94	3	assay	assay	NOUN
admet-280	94	4	and	and	CCONJ
admet-280	94	5	lc	lc	PROPN
admet-280	94	6	-	-	PUNCT
admet-280	94	7	ms	ms	PROPN
admet-280	94	8	/	/	SYM
admet-280	94	9	ms	ms	ADJ
admet-280	94	10	two	two	NUM
admet-280	94	11	cyp	cyp	ADJ
admet-280	94	12	cocktail	cocktail	NOUN
admet-280	94	13	assays	assay	NOUN
admet-280	94	14	developed	develop	VERB
admet-280	94	15	in	in	ADP
admet-280	94	16	dr	dr	PROPN
admet-280	94	17	.	.	PROPN
admet-280	94	18	jashvant	jashvant	PROPN
admet-280	94	19	unadkat	unadkat	PROPN
admet-280	94	20	’s	’s	PART
admet-280	94	21	lab	lab	NOUN
admet-280	94	22	at	at	ADP
admet-280	94	23	the	the	DET
admet-280	94	24	university	university	PROPN
admet-280	94	25	of	of	ADP
admet-280	94	26	washington	washington	PROPN
admet-280	94	27	were	be	AUX
admet-280	94	28	used	use	VERB
admet-280	94	29	to	to	PART
admet-280	94	30	assess	assess	VERB
admet-280	94	31	functional	functional	ADJ
admet-280	94	32	cyp	cyp	ADJ
admet-280	94	33	activity	activity	NOUN
admet-280	95	1	[	[	X
admet-280	95	2	14	14	NUM
admet-280	95	3	]	]	PUNCT
admet-280	95	4	.	.	PUNCT
admet-280	96	1	cocktail	cocktail	VERB
admet-280	96	2	a	a	DET
admet-280	96	3	assesses	assesse	NOUN
admet-280	96	4	cyps	cyps	PROPN
admet-280	96	5	3a	3a	NUM
admet-280	96	6	,	,	PUNCT
admet-280	96	7	2c9	2c9	NUM
admet-280	96	8	,	,	PUNCT
admet-280	96	9	1a	1a	NUM
admet-280	96	10	,	,	PUNCT
admet-280	96	11	2d6	2d6	NUM
admet-280	96	12	,	,	PUNCT
admet-280	96	13	2a6	2a6	NUM
admet-280	96	14	,	,	PUNCT
admet-280	96	15	and	and	CCONJ
admet-280	96	16	cocktail	cocktail	NOUN
admet-280	96	17	b	b	PROPN
admet-280	96	18	assesses	assesse	NOUN
admet-280	96	19	cyps	cyps	PROPN
admet-280	96	20	2b6	2b6	NUM
admet-280	96	21	,	,	PUNCT
admet-280	96	22	2c8	2c8	NUM
admet-280	96	23	,	,	PUNCT
admet-280	96	24	and	and	CCONJ
admet-280	96	25	2e1	2e1	NUM
admet-280	96	26	.	.	X
admet-280	97	1	acetaminophen	acetaminophen	NOUN
admet-280	97	2	,	,	PUNCT
admet-280	97	3	amodiaquine	amodiaquine	PROPN
admet-280	97	4	dihydrochloride	dihydrochloride	PROPN
admet-280	97	5	dihydrate	dihydrate	PROPN
admet-280	97	6	,	,	PUNCT
admet-280	97	7	bupropion	bupropion	NOUN
admet-280	97	8	,	,	PUNCT
admet-280	97	9	chlorzoxazone	chlorzoxazone	NOUN
admet-280	97	10	,	,	PUNCT
admet-280	97	11	coumarin	coumarin	NOUN
admet-280	97	12	,	,	PUNCT
admet-280	97	13	phenacetin	phenacetin	NOUN
admet-280	97	14	,	,	PUNCT
admet-280	97	15	and	and	CCONJ
admet-280	97	16	tolbutamide	tolbutamide	NOUN
admet-280	97	17	were	be	AUX
admet-280	97	18	purchased	purchase	VERB
admet-280	97	19	from	from	ADP
admet-280	97	20	sigma	sigma	PROPN
admet-280	97	21	.	.	PUNCT
admet-280	98	1	dextromethorphan	dextromethorphan	PROPN
admet-280	98	2	,	,	PUNCT
admet-280	98	3	d5	d5	NOUN
admet-280	98	4	-	-	PUNCT
admet-280	98	5	diazepam	diazepam	NOUN
admet-280	98	6	,	,	PUNCT
admet-280	98	7	dextrorphan	dextrorphan	NOUN
admet-280	98	8	,	,	PUNCT
admet-280	98	9	testosterone	testosterone	NOUN
admet-280	98	10	,	,	PUNCT
admet-280	98	11	n	n	CCONJ
admet-280	98	12	-	-	PUNCT
admet-280	98	13	desethylamodiaquine	desethylamodiaquine	ADJ
admet-280	98	14	,	,	PUNCT
admet-280	98	15	hydroxy	hydroxy	NOUN
admet-280	98	16	-	-	PUNCT
admet-280	98	17	bupropion	bupropion	NOUN
admet-280	98	18	,	,	PUNCT
admet-280	98	19	4hydroxytolbutamide	4hydroxytolbutamide	NUM
admet-280	98	20	,	,	PUNCT
admet-280	98	21	6	6	NUM
admet-280	98	22	-	-	PUNCT
admet-280	98	23	hydroxychlorzoxazone	hydroxychlorzoxazone	NOUN
admet-280	98	24	,	,	PUNCT
admet-280	98	25	and	and	CCONJ
admet-280	98	26	6	6	NUM
admet-280	98	27	-	-	PUNCT
admet-280	98	28	β	β	NOUN
admet-280	98	29	-	-	NOUN
admet-280	98	30	hydroxytestosterone	hydroxytestosterone	NOUN
admet-280	98	31	were	be	AUX
admet-280	98	32	purchased	purchase	VERB
admet-280	98	33	from	from	ADP
admet-280	98	34	cerilliant	cerilliant	PROPN
admet-280	98	35	(	(	PUNCT
admet-280	98	36	round	round	NOUN
admet-280	98	37	rock	rock	NOUN
admet-280	98	38	,	,	PUNCT
admet-280	98	39	tx	tx	PROPN
admet-280	98	40	)	)	PUNCT
admet-280	98	41	.	.	PUNCT
admet-280	99	1	7	7	NUM
admet-280	99	2	-	-	PUNCT
admet-280	99	3	hydroxycoumarin	hydroxycoumarin	NOUN
admet-280	99	4	was	be	AUX
admet-280	99	5	a	a	DET
admet-280	99	6	kind	kind	ADJ
admet-280	99	7	gift	gift	NOUN
admet-280	99	8	from	from	ADP
admet-280	99	9	dr	dr	PROPN
admet-280	99	10	.	.	PROPN
admet-280	99	11	unadkat	unadkat	PROPN
admet-280	99	12	’s	’s	PART
admet-280	99	13	lab	lab	NOUN
admet-280	99	14	.	.	PUNCT
admet-280	100	1	for	for	ADP
admet-280	100	2	the	the	DET
admet-280	100	3	analytical	analytical	ADJ
admet-280	100	4	assays	assay	NOUN
admet-280	100	5	,	,	PUNCT
admet-280	100	6	a	a	DET
admet-280	100	7	set	set	NOUN
admet-280	100	8	of	of	ADP
admet-280	100	9	metabolite	metabolite	NOUN
admet-280	100	10	standards	standard	NOUN
admet-280	100	11	with	with	ADP
admet-280	100	12	nine	nine	NUM
admet-280	100	13	calibration	calibration	NOUN
admet-280	100	14	points	point	NOUN
admet-280	100	15	and	and	CCONJ
admet-280	100	16	a	a	DET
admet-280	100	17	separate	separate	ADJ
admet-280	100	18	set	set	NOUN
admet-280	100	19	of	of	ADP
admet-280	100	20	three	three	NUM
admet-280	100	21	quality	quality	NOUN
admet-280	100	22	control	control	NOUN
admet-280	100	23	(	(	PUNCT
admet-280	100	24	qc	qc	PROPN
admet-280	100	25	)	)	PUNCT
admet-280	100	26	samples	sample	NOUN
admet-280	100	27	were	be	AUX
admet-280	100	28	prepared	prepare	VERB
admet-280	100	29	.	.	PUNCT
admet-280	101	1	the	the	DET
admet-280	101	2	calibrator	calibrator	NOUN
admet-280	101	3	concentration	concentration	NOUN
admet-280	101	4	ranges	range	NOUN
admet-280	101	5	were	be	AUX
admet-280	101	6	:	:	PUNCT
admet-280	101	7	acetaminophen	acetaminophen	NOUN
admet-280	101	8	,	,	PUNCT
admet-280	101	9	0.031	0.031	NUM
admet-280	101	10	-	-	SYM
admet-280	101	11	8	8	NUM
admet-280	101	12	μm	μm	NUM
admet-280	101	13	;	;	PUNCT
admet-280	101	14	oh	oh	NUM
admet-280	101	15	-	-	PUNCT
admet-280	101	16	bupropion	bupropion	NOUN
admet-280	101	17	,	,	PUNCT
admet-280	101	18	0.002	0.002	NUM
admet-280	101	19	-	-	SYM
admet-280	101	20	0.5	0.5	NUM
admet-280	101	21	μm	μm	NUM
admet-280	101	22	;	;	PUNCT
admet-280	101	23	4	4	NUM
admet-280	101	24	-	-	PUNCT
admet-280	101	25	oh	oh	NUM
admet-280	101	26	-	-	PUNCT
admet-280	101	27	tolbutamide	tolbutamide	NOUN
admet-280	101	28	,	,	PUNCT
admet-280	101	29	0.013	0.013	NUM
admet-280	101	30	-	-	SYM
admet-280	101	31	3.3	3.3	NUM
admet-280	101	32	μm	μm	NOUN
admet-280	101	33	;	;	PUNCT
admet-280	101	34	6	6	NUM
admet-280	101	35	-	-	PUNCT
admet-280	101	36	ohtestosterone	ohtestosterone	NOUN
admet-280	101	37	,	,	PUNCT
admet-280	101	38	0.31	0.31	NUM
admet-280	101	39	-	-	SYM
admet-280	101	40	80	80	NUM
admet-280	101	41	μm	μm	NUM
admet-280	101	42	;	;	PUNCT
admet-280	101	43	6	6	NUM
admet-280	101	44	-	-	PUNCT
admet-280	101	45	oh	oh	NUM
admet-280	101	46	-	-	PUNCT
admet-280	101	47	chlorzoxazone	chlorzoxazone	NOUN
admet-280	101	48	,	,	PUNCT
admet-280	101	49	0.0625	0.0625	NUM
admet-280	101	50	-	-	SYM
admet-280	101	51	16	16	NUM
admet-280	101	52	μm	μm	NUM
admet-280	101	53	;	;	PUNCT
admet-280	101	54	7	7	NUM
admet-280	101	55	-	-	PUNCT
admet-280	101	56	oh	oh	NUM
admet-280	101	57	-	-	PUNCT
admet-280	101	58	coumarin	coumarin	NOUN
admet-280	101	59	,	,	PUNCT
admet-280	101	60	0.0042	0.0042	NUM
admet-280	101	61	-	-	SYM
admet-280	101	62	1.08	1.08	NUM
admet-280	101	63	μm	μm	NOUN
admet-280	101	64	;	;	PUNCT
admet-280	101	65	ndesethylamodiaquine	ndesethylamodiaquine	NOUN
admet-280	101	66	,	,	PUNCT
admet-280	101	67	0.0083	0.0083	NUM
admet-280	101	68	-	-	SYM
admet-280	101	69	2.12	2.12	NUM
admet-280	101	70	μm	μm	NUM
admet-280	101	71	;	;	PUNCT
admet-280	101	72	dextrorphan	dextrorphan	ADJ
admet-280	101	73	,	,	PUNCT
admet-280	101	74	0.0017	0.0017	NUM
admet-280	101	75	-	-	SYM
admet-280	101	76	0.44	0.44	NUM
admet-280	101	77	μm	μm	NOUN
admet-280	101	78	.	.	PUNCT
admet-280	102	1	the	the	DET
admet-280	102	2	qc	qc	PROPN
admet-280	102	3	concentration	concentration	NOUN
admet-280	102	4	ranges	range	NOUN
admet-280	102	5	were	be	AUX
admet-280	102	6	:	:	PUNCT
admet-280	102	7	acetaminophen	acetaminophen	NOUN
admet-280	102	8	,	,	PUNCT
admet-280	102	9	0.125	0.125	NUM
admet-280	102	10	-	-	SYM
admet-280	102	11	4	4	NUM
admet-280	102	12	μm	μm	NUM
admet-280	102	13	;	;	PUNCT
admet-280	102	14	oh	oh	NUM
admet-280	102	15	-	-	PUNCT
admet-280	102	16	bupropion	bupropion	NOUN
admet-280	102	17	,	,	PUNCT
admet-280	102	18	0.0078	0.0078	NUM
admet-280	102	19	-	-	SYM
admet-280	102	20	0.25	0.25	NUM
admet-280	102	21	μm	μm	NOUN
admet-280	102	22	;	;	PUNCT
admet-280	102	23	4	4	NUM
admet-280	102	24	-	-	PUNCT
admet-280	102	25	oh	oh	NUM
admet-280	102	26	-	-	PUNCT
admet-280	102	27	tolbutamide	tolbutamide	NOUN
admet-280	102	28	,	,	PUNCT
admet-280	102	29	0.052	0.052	NUM
admet-280	102	30	-	-	SYM
admet-280	102	31	1.66	1.66	NUM
admet-280	102	32	μm	μm	NUM
admet-280	102	33	;	;	PUNCT
admet-280	102	34	6	6	NUM
admet-280	102	35	-	-	PUNCT
admet-280	102	36	ohtestosterone	ohtestosterone	NOUN
admet-280	102	37	,	,	PUNCT
admet-280	102	38	1.25	1.25	NUM
admet-280	102	39	-	-	SYM
admet-280	102	40	40	40	NUM
admet-280	102	41	μm	μm	NUM
admet-280	102	42	;	;	PUNCT
admet-280	102	43	6	6	NUM
admet-280	102	44	-	-	PUNCT
admet-280	102	45	oh	oh	NUM
admet-280	102	46	-	-	PUNCT
admet-280	102	47	chlorzoxazone	chlorzoxazone	NOUN
admet-280	102	48	,	,	PUNCT
admet-280	102	49	0.25	0.25	NUM
admet-280	102	50	-	-	SYM
admet-280	102	51	8	8	NUM
admet-280	102	52	μm	μm	NUM
admet-280	102	53	;	;	PUNCT
admet-280	102	54	7	7	NUM
admet-280	102	55	-	-	PUNCT
admet-280	102	56	oh	oh	NUM
admet-280	102	57	-	-	PUNCT
admet-280	102	58	coumarin	coumarin	NOUN
admet-280	102	59	,	,	PUNCT
admet-280	102	60	0.017	0.017	NUM
admet-280	102	61	-	-	SYM
admet-280	102	62	0.54	0.54	NUM
admet-280	102	63	μm	μm	NUM
admet-280	102	64	;	;	PUNCT
admet-280	102	65	ndesethylamodiaquine	ndesethylamodiaquine	NOUN
admet-280	102	66	,	,	PUNCT
admet-280	102	67	0.033	0.033	NUM
admet-280	102	68	-	-	SYM
admet-280	102	69	1.06	1.06	NUM
admet-280	102	70	μm	μm	NUM
admet-280	102	71	;	;	PUNCT
admet-280	102	72	dextrorphan	dextrorphan	ADJ
admet-280	102	73	,	,	PUNCT
admet-280	102	74	0.0068	0.0068	NUM
admet-280	102	75	-	-	SYM
admet-280	102	76	0.22	0.22	NUM
admet-280	102	77	μm	μm	NOUN
admet-280	102	78	.	.	PUNCT
admet-280	103	1	all	all	DET
admet-280	103	2	calibrator	calibrator	NOUN
admet-280	103	3	and	and	CCONJ
admet-280	103	4	qc	qc	PROPN
admet-280	103	5	points	point	NOUN
admet-280	103	6	were	be	AUX
admet-280	103	7	made	make	VERB
admet-280	103	8	in	in	ADP
admet-280	103	9	hepatozyme	hepatozyme	NOUN
admet-280	103	10	maturation	maturation	NOUN
admet-280	103	11	media	medium	NOUN
admet-280	103	12	,	,	PUNCT
admet-280	103	13	an	an	DET
admet-280	103	14	equal	equal	ADJ
admet-280	103	15	volume	volume	NOUN
admet-280	103	16	of	of	ADP
admet-280	103	17	calibrator	calibrator	NOUN
admet-280	103	18	or	or	CCONJ
admet-280	103	19	qc	qc	PROPN
admet-280	103	20	was	be	AUX
admet-280	103	21	then	then	ADV
admet-280	103	22	added	add	VERB
admet-280	103	23	to	to	ADP
admet-280	103	24	an	an	DET
admet-280	103	25	equal	equal	ADJ
admet-280	103	26	volume	volume	NOUN
admet-280	103	27	of	of	ADP
admet-280	103	28	acetonitrile	acetonitrile	NOUN
admet-280	103	29	containing	contain	VERB
admet-280	103	30	0.06	0.06	NUM
admet-280	103	31	ng	ng	PROPN
admet-280	103	32	/	/	SYM
admet-280	103	33	μl	μl	PROPN
admet-280	103	34	of	of	ADP
admet-280	103	35	internal	internal	ADJ
admet-280	103	36	standard	standard	ADJ
admet-280	103	37	d5	d5	NOUN
admet-280	103	38	-	-	PUNCT
admet-280	103	39	diazepam	diazepam	NOUN
admet-280	103	40	and	and	CCONJ
admet-280	103	41	centrifuged	centrifuge	VERB
admet-280	103	42	at	at	ADP
admet-280	103	43	13,000	13,000	NUM
admet-280	103	44	rpm	rpm	NOUN
admet-280	103	45	for	for	ADP
admet-280	103	46	10	10	NUM
admet-280	103	47	minutes	minute	NOUN
admet-280	103	48	.	.	PUNCT
admet-280	104	1	the	the	DET
admet-280	104	2	supernatant	supernatant	NOUN
admet-280	104	3	was	be	AUX
admet-280	104	4	removed	remove	VERB
admet-280	104	5	and	and	CCONJ
admet-280	104	6	stored	store	VERB
admet-280	104	7	at	at	ADP
admet-280	104	8	4	4	NUM
admet-280	104	9	°	°	ADP
admet-280	104	10	c	c	NOUN
admet-280	104	11	until	until	ADP
admet-280	104	12	analysis	analysis	NOUN
admet-280	104	13	.	.	PUNCT
admet-280	105	1	cyp	cyp	ADJ
admet-280	105	2	assay	assay	ADJ
admet-280	105	3	incubations	incubation	NOUN
admet-280	105	4	were	be	AUX
admet-280	105	5	performed	perform	VERB
admet-280	105	6	on	on	ADP
admet-280	105	7	day	day	NOUN
admet-280	105	8	17	17	NUM
admet-280	105	9	scdhs	scdhs	ADJ
admet-280	105	10	and	and	CCONJ
admet-280	105	11	cryopreserved	cryopreserve	VERB
admet-280	105	12	hepatocytes	hepatocytes	PROPN
admet-280	105	13	lots	lot	NOUN
admet-280	105	14	hum4012	hum4012	VERB
admet-280	105	15	and	and	CCONJ
admet-280	105	16	hum4034	hum4034	NOUN
admet-280	105	17	.	.	PUNCT
admet-280	106	1	incubations	incubation	NOUN
admet-280	106	2	were	be	AUX
admet-280	106	3	performed	perform	VERB
admet-280	106	4	as	as	SCONJ
admet-280	106	5	described	describe	VERB
admet-280	106	6	by	by	ADP
admet-280	106	7	liu	liu	PROPN
admet-280	106	8	et	et	PROPN
admet-280	106	9	al	al	PROPN
admet-280	106	10	.	.	PROPN
admet-280	106	11	,	,	PUNCT
admet-280	106	12	with	with	ADP
admet-280	106	13	some	some	DET
admet-280	106	14	modifications	modification	NOUN
admet-280	106	15	[	[	X
admet-280	106	16	14	14	NUM
admet-280	106	17	]	]	PUNCT
admet-280	106	18	.	.	PUNCT
admet-280	107	1	briefly	briefly	NOUN
admet-280	107	2	,	,	PUNCT
admet-280	107	3	standard	standard	ADJ
admet-280	107	4	stock	stock	NOUN
admet-280	107	5	mixtures	mixture	NOUN
admet-280	107	6	of	of	ADP
admet-280	107	7	cocktail	cocktail	NOUN
admet-280	107	8	a	a	PRON
admet-280	107	9	and	and	CCONJ
admet-280	107	10	b	b	NOUN
admet-280	107	11	were	be	AUX
admet-280	107	12	prepared	prepare	VERB
admet-280	107	13	and	and	CCONJ
admet-280	107	14	diluted	dilute	VERB
admet-280	107	15	in	in	ADP
admet-280	107	16	hepatozyme	hepatozyme	NOUN
admet-280	107	17	maturation	maturation	NOUN
admet-280	107	18	media	medium	NOUN
admet-280	107	19	for	for	ADP
admet-280	107	20	cell	cell	NOUN
admet-280	107	21	incubations	incubation	NOUN
admet-280	107	22	to	to	ADP
admet-280	107	23	the	the	DET
admet-280	107	24	following	following	ADJ
admet-280	107	25	final	final	ADJ
admet-280	107	26	concentrations	concentration	NOUN
admet-280	107	27	:	:	PUNCT
admet-280	107	28	cocktail	cocktail	VERB
admet-280	107	29	a	a	DET
admet-280	107	30	,	,	PUNCT
admet-280	107	31	tolbutamide	tolbutamide	NOUN
admet-280	107	32	,	,	PUNCT
admet-280	107	33	75	75	NUM
admet-280	107	34	μm	μm	NUM
admet-280	107	35	,	,	PUNCT
admet-280	107	36	testosterone	testosterone	NOUN
admet-280	107	37	,	,	PUNCT
admet-280	107	38	100	100	NUM
admet-280	107	39	μm	μm	NUM
admet-280	107	40	,	,	PUNCT
admet-280	107	41	dextromethorphan	dextromethorphan	PROPN
admet-280	107	42	,	,	PUNCT
admet-280	107	43	5	5	NUM
admet-280	107	44	μm	μm	NOUN
admet-280	107	45	,	,	PUNCT
admet-280	107	46	coumarin	coumarin	NOUN
admet-280	107	47	,	,	PUNCT
admet-280	107	48	0.5	0.5	NUM
admet-280	107	49	μm	μm	NUM
admet-280	107	50	,	,	PUNCT
admet-280	107	51	phenacetin	phenacetin	NOUN
admet-280	107	52	,	,	PUNCT
admet-280	107	53	50	50	NUM
admet-280	107	54	μm	μm	NOUN
admet-280	107	55	;	;	PUNCT
admet-280	107	56	cocktail	cocktail	NOUN
admet-280	107	57	b	b	NOUN
admet-280	107	58	,	,	PUNCT
admet-280	107	59	bupropion	bupropion	NOUN
admet-280	107	60	,	,	PUNCT
admet-280	107	61	100	100	NUM
admet-280	107	62	μm	μm	NUM
admet-280	107	63	,	,	PUNCT
admet-280	107	64	amodiaquine	amodiaquine	PROPN
admet-280	107	65	,	,	PUNCT
admet-280	107	66	4	4	NUM
admet-280	107	67	μm	μm	NOUN
admet-280	107	68	,	,	PUNCT
admet-280	107	69	chlorzoxazone	chlorzoxazone	NOUN
admet-280	107	70	,	,	PUNCT
admet-280	107	71	25	25	NUM
admet-280	107	72	μm	μm	NOUN
admet-280	107	73	.	.	PUNCT
admet-280	108	1	the	the	DET
admet-280	108	2	final	final	ADJ
admet-280	108	3	concentration	concentration	NOUN
admet-280	108	4	of	of	ADP
admet-280	108	5	organic	organic	ADJ
admet-280	108	6	solvent	solvent	NOUN
admet-280	108	7	in	in	ADP
admet-280	108	8	cell	cell	NOUN
admet-280	108	9	incubations	incubation	NOUN
admet-280	108	10	was	be	AUX
admet-280	108	11	1	1	NUM
admet-280	108	12	%	%	NOUN
admet-280	108	13	.	.	PUNCT
admet-280	109	1	cocktail	cocktail	NOUN
admet-280	109	2	incubations	incubation	NOUN
admet-280	109	3	with	with	ADP
admet-280	109	4	scdhs	scdhs	PROPN
admet-280	109	5	were	be	AUX
admet-280	109	6	performed	perform	VERB
admet-280	109	7	for	for	ADP
admet-280	109	8	2	2	NUM
admet-280	109	9	hours	hour	NOUN
admet-280	109	10	at	at	ADP
admet-280	109	11	37	37	NUM
admet-280	109	12	°	°	NOUN
admet-280	109	13	c	c	NOUN
admet-280	109	14	.	.	PUNCT
admet-280	110	1	at	at	ADP
admet-280	110	2	the	the	DET
admet-280	110	3	end	end	NOUN
admet-280	110	4	of	of	ADP
admet-280	110	5	the	the	DET
admet-280	110	6	incubation	incubation	NOUN
admet-280	110	7	admet	admet	NOUN
admet-280	110	8	&	&	CCONJ
admet-280	110	9	dmpk	dmpk	PROPN
admet-280	110	10	4(2	4(2	NUM
admet-280	110	11	)	)	PUNCT
admet-280	110	12	(	(	PUNCT
admet-280	110	13	2016	2016	NUM
admet-280	110	14	)	)	PUNCT
admet-280	110	15	62	62	NUM
admet-280	110	16	-	-	SYM
admet-280	110	17	83	83	NUM
admet-280	110	18	pharmacogenetics	pharmacogenetic	NOUN
admet-280	110	19	and	and	CCONJ
admet-280	110	20	cyp	cyp	ADJ
admet-280	110	21	activity	activity	NOUN
admet-280	110	22	doi	doi	NOUN
admet-280	110	23	:	:	PUNCT
admet-280	110	24	10.5599	10.5599	NUM
admet-280	110	25	/	/	SYM
admet-280	110	26	admet.4.2.280	admet.4.2.280	NUM
admet-280	110	27	67	67	NUM
admet-280	110	28	period	period	NOUN
admet-280	110	29	,	,	PUNCT
admet-280	110	30	the	the	DET
admet-280	110	31	media	medium	NOUN
admet-280	110	32	was	be	AUX
admet-280	110	33	collected	collect	VERB
admet-280	110	34	and	and	CCONJ
admet-280	110	35	added	add	VERB
admet-280	110	36	to	to	ADP
admet-280	110	37	an	an	DET
admet-280	110	38	equal	equal	ADJ
admet-280	110	39	volume	volume	NOUN
admet-280	110	40	of	of	ADP
admet-280	110	41	acetonitrile	acetonitrile	NOUN
admet-280	110	42	containing	contain	VERB
admet-280	110	43	0.06	0.06	NUM
admet-280	110	44	ng	ng	PROPN
admet-280	110	45	/	/	SYM
admet-280	110	46	μl	μl	PROPN
admet-280	110	47	d5diazepam	d5diazepam	NOUN
admet-280	110	48	.	.	PUNCT
admet-280	111	1	cocktail	cocktail	NOUN
admet-280	111	2	incubations	incubation	NOUN
admet-280	111	3	with	with	ADP
admet-280	111	4	cryopreserved	cryopreserved	ADJ
admet-280	111	5	hepatocytes	hepatocyte	NOUN
admet-280	111	6	were	be	AUX
admet-280	111	7	performed	perform	VERB
admet-280	111	8	for	for	ADP
admet-280	111	9	30	30	NUM
admet-280	111	10	minutes	minute	NOUN
admet-280	111	11	or	or	CCONJ
admet-280	111	12	1	1	NUM
admet-280	111	13	hour	hour	NOUN
admet-280	111	14	at	at	ADP
admet-280	111	15	37	37	NUM
admet-280	111	16	°	°	NOUN
admet-280	111	17	c	c	NOUN
admet-280	111	18	,	,	PUNCT
admet-280	111	19	media	medium	NOUN
admet-280	111	20	was	be	AUX
admet-280	111	21	collected	collect	VERB
admet-280	111	22	at	at	ADP
admet-280	111	23	the	the	DET
admet-280	111	24	end	end	NOUN
admet-280	111	25	of	of	ADP
admet-280	111	26	the	the	DET
admet-280	111	27	incubation	incubation	NOUN
admet-280	111	28	and	and	CCONJ
admet-280	111	29	added	add	VERB
admet-280	111	30	to	to	ADP
admet-280	111	31	an	an	DET
admet-280	111	32	equal	equal	ADJ
admet-280	111	33	volume	volume	NOUN
admet-280	111	34	of	of	ADP
admet-280	111	35	acetonitrile	acetonitrile	NOUN
admet-280	111	36	containing	contain	VERB
admet-280	111	37	d5	d5	NOUN
admet-280	111	38	-	-	PUNCT
admet-280	111	39	diazepam	diazepam	NOUN
admet-280	111	40	.	.	PUNCT
admet-280	112	1	all	all	DET
admet-280	112	2	incubation	incubation	NOUN
admet-280	112	3	samples	sample	NOUN
admet-280	112	4	were	be	AUX
admet-280	112	5	centrifuged	centrifuge	VERB
admet-280	112	6	at	at	ADP
admet-280	112	7	13,000	13,000	NUM
admet-280	112	8	rpm	rpm	NOUN
admet-280	112	9	for	for	ADP
admet-280	112	10	10	10	NUM
admet-280	112	11	minutes	minute	NOUN
admet-280	112	12	.	.	PUNCT
admet-280	113	1	the	the	DET
admet-280	113	2	supernatant	supernatant	NOUN
admet-280	113	3	was	be	AUX
admet-280	113	4	removed	remove	VERB
admet-280	113	5	and	and	CCONJ
admet-280	113	6	stored	store	VERB
admet-280	113	7	at	at	ADP
admet-280	113	8	4	4	NUM
admet-280	113	9	°	°	ADP
admet-280	113	10	c	c	NOUN
admet-280	113	11	until	until	ADP
admet-280	113	12	analysis	analysis	NOUN
admet-280	113	13	.	.	PUNCT
admet-280	114	1	the	the	DET
admet-280	114	2	cyp	cyp	ADJ
admet-280	114	3	assay	assay	NOUN
admet-280	114	4	metabolites	metabolite	NOUN
admet-280	114	5	were	be	AUX
admet-280	114	6	analyzed	analyze	VERB
admet-280	114	7	using	use	VERB
admet-280	114	8	an	an	DET
admet-280	114	9	agilent	agilent	PROPN
admet-280	114	10	6460	6460	NUM
admet-280	114	11	triple	triple	ADJ
admet-280	114	12	quadrupole	quadrupole	NOUN
admet-280	114	13	mass	mass	NOUN
admet-280	114	14	spectrometer	spectrometer	NOUN
admet-280	114	15	(	(	PUNCT
admet-280	114	16	agilent	agilent	PROPN
admet-280	114	17	technologies	technologies	PROPN
admet-280	114	18	,	,	PUNCT
admet-280	114	19	santa	santa	PROPN
admet-280	114	20	clara	clara	PROPN
admet-280	114	21	,	,	PUNCT
admet-280	114	22	ca	ca	NOUN
admet-280	114	23	)	)	PUNCT
admet-280	114	24	in	in	ADP
admet-280	114	25	the	the	DET
admet-280	114	26	university	university	PROPN
admet-280	114	27	of	of	ADP
admet-280	114	28	washington	washington	PROPN
admet-280	114	29	mass	mass	PROPN
admet-280	114	30	spectrometry	spectrometry	NOUN
admet-280	114	31	center	center	NOUN
admet-280	114	32	as	as	SCONJ
admet-280	114	33	described	describe	VERB
admet-280	114	34	by	by	ADP
admet-280	114	35	liu	liu	PROPN
admet-280	114	36	et	et	PROPN
admet-280	114	37	al	al	PROPN
admet-280	114	38	.	.	PROPN
admet-280	114	39	,	,	PUNCT
admet-280	114	40	with	with	ADP
admet-280	114	41	minor	minor	ADJ
admet-280	114	42	modifications	modification	NOUN
admet-280	114	43	[	[	X
admet-280	114	44	14	14	NUM
admet-280	114	45	]	]	PUNCT
admet-280	114	46	.	.	PUNCT
admet-280	115	1	briefly	briefly	NOUN
admet-280	115	2	,	,	PUNCT
admet-280	115	3	hplc	hplc	NOUN
admet-280	115	4	separation	separation	NOUN
admet-280	115	5	was	be	AUX
admet-280	115	6	achieved	achieve	VERB
admet-280	115	7	using	use	VERB
admet-280	115	8	an	an	DET
admet-280	115	9	agilent	agilent	PROPN
admet-280	115	10	xdb	xdb	PROPN
admet-280	115	11	c18	c18	NOUN
admet-280	115	12	2.1	2.1	NUM
admet-280	115	13	x	x	SYM
admet-280	115	14	150	150	NUM
admet-280	115	15	mm	mm	NOUN
admet-280	115	16	,	,	PUNCT
admet-280	115	17	5	5	NUM
admet-280	115	18	μm	μm	NOUN
admet-280	115	19	column	column	NOUN
admet-280	115	20	.	.	PUNCT
admet-280	116	1	compounds	compound	NOUN
admet-280	116	2	were	be	AUX
admet-280	116	3	eluted	elute	VERB
admet-280	116	4	at	at	ADP
admet-280	116	5	a	a	DET
admet-280	116	6	flow	flow	NOUN
admet-280	116	7	rate	rate	NOUN
admet-280	116	8	of	of	ADP
admet-280	116	9	0.25	0.25	NUM
admet-280	116	10	ml	ml	NOUN
admet-280	116	11	/	/	SYM
admet-280	116	12	min	min	NOUN
admet-280	116	13	,	,	PUNCT
admet-280	116	14	using	use	VERB
admet-280	116	15	the	the	DET
admet-280	116	16	following	follow	VERB
admet-280	116	17	gradient	gradient	NOUN
admet-280	116	18	of	of	ADP
admet-280	116	19	0.1	0.1	NUM
admet-280	116	20	%	%	NOUN
admet-280	116	21	formic	formic	ADJ
admet-280	116	22	acid	acid	NOUN
admet-280	116	23	in	in	ADP
admet-280	116	24	water	water	NOUN
admet-280	116	25	(	(	PUNCT
admet-280	116	26	solvent	solvent	NOUN
admet-280	116	27	a	a	NOUN
admet-280	116	28	)	)	PUNCT
admet-280	116	29	and	and	CCONJ
admet-280	116	30	0.1	0.1	NUM
admet-280	116	31	%	%	NOUN
admet-280	116	32	formic	formic	ADJ
admet-280	116	33	acid	acid	NOUN
admet-280	116	34	in	in	ADP
admet-280	116	35	acetonitrile	acetonitrile	NOUN
admet-280	116	36	(	(	PUNCT
admet-280	116	37	solvent	solvent	NOUN
admet-280	116	38	b	b	NOUN
admet-280	116	39	):	):	PUNCT
admet-280	116	40	for	for	ADP
admet-280	116	41	the	the	DET
admet-280	116	42	first	first	ADJ
admet-280	116	43	1.5	1.5	NUM
admet-280	116	44	minutes	minute	NOUN
admet-280	116	45	,	,	PUNCT
admet-280	117	1	99	99	NUM
admet-280	117	2	%	%	NOUN
admet-280	117	3	solvent	solvent	NOUN
admet-280	117	4	a	a	PRON
admet-280	117	5	,	,	PUNCT
admet-280	117	6	a	a	DET
admet-280	117	7	linear	linear	ADJ
admet-280	117	8	decrease	decrease	NOUN
admet-280	117	9	to	to	ADP
admet-280	117	10	70	70	NUM
admet-280	117	11	%	%	NOUN
admet-280	117	12	solvent	solvent	NOUN
admet-280	117	13	a	a	PRON
admet-280	117	14	until	until	ADP
admet-280	117	15	4	4	NUM
admet-280	117	16	minutes	minute	NOUN
admet-280	117	17	,	,	PUNCT
admet-280	117	18	maintained	maintain	VERB
admet-280	117	19	at	at	ADP
admet-280	117	20	70	70	NUM
admet-280	117	21	%	%	NOUN
admet-280	117	22	solvent	solvent	NOUN
admet-280	117	23	a	a	PRON
admet-280	117	24	until	until	ADP
admet-280	117	25	6	6	NUM
admet-280	117	26	minutes	minute	NOUN
admet-280	117	27	,	,	PUNCT
admet-280	117	28	a	a	DET
admet-280	117	29	linear	linear	ADJ
admet-280	117	30	decrease	decrease	NOUN
admet-280	117	31	to	to	ADP
admet-280	117	32	25	25	NUM
admet-280	117	33	%	%	NOUN
admet-280	117	34	solvent	solvent	NOUN
admet-280	117	35	a	a	PRON
admet-280	117	36	until	until	ADP
admet-280	117	37	9	9	NUM
admet-280	117	38	minutes	minute	NOUN
admet-280	117	39	and	and	CCONJ
admet-280	117	40	held	hold	VERB
admet-280	117	41	at	at	ADP
admet-280	117	42	25	25	NUM
admet-280	117	43	%	%	NOUN
admet-280	117	44	solvent	solvent	NOUN
admet-280	117	45	a	a	PRON
admet-280	117	46	until	until	ADP
admet-280	117	47	13	13	NUM
admet-280	117	48	minutes	minute	NOUN
admet-280	117	49	to	to	PART
admet-280	117	50	wash	wash	VERB
admet-280	117	51	and	and	CCONJ
admet-280	117	52	cycled	cycle	VERB
admet-280	117	53	back	back	ADV
admet-280	117	54	to	to	ADP
admet-280	117	55	initial	initial	ADJ
admet-280	117	56	conditions	condition	NOUN
admet-280	117	57	.	.	PUNCT
admet-280	118	1	the	the	DET
admet-280	118	2	column	column	NOUN
admet-280	118	3	was	be	AUX
admet-280	118	4	allowed	allow	VERB
admet-280	118	5	to	to	PART
admet-280	118	6	reequilibrate	reequilibrate	VERB
admet-280	118	7	for	for	ADP
admet-280	118	8	4	4	NUM
admet-280	118	9	minutes	minute	NOUN
admet-280	118	10	before	before	SCONJ
admet-280	118	11	the	the	DET
admet-280	118	12	next	next	ADJ
admet-280	118	13	sample	sample	NOUN
admet-280	118	14	was	be	AUX
admet-280	118	15	injected	inject	VERB
admet-280	118	16	.	.	PUNCT
admet-280	119	1	results	result	NOUN
admet-280	119	2	and	and	CCONJ
admet-280	119	3	discussion	discussion	VERB
admet-280	119	4	the	the	DET
admet-280	119	5	university	university	PROPN
admet-280	119	6	of	of	ADP
admet-280	119	7	wisconsin	wisconsin	PROPN
admet-280	119	8	has	have	AUX
admet-280	119	9	made	make	VERB
admet-280	119	10	wicell	wicell	ADJ
admet-280	119	11	®	®	NOUN
admet-280	119	12	lines	line	NOUN
admet-280	119	13	available	available	ADJ
admet-280	119	14	to	to	ADP
admet-280	119	15	researchers	researcher	NOUN
admet-280	119	16	for	for	ADP
admet-280	119	17	well	well	ADV
admet-280	119	18	over	over	ADP
admet-280	119	19	a	a	PRON
admet-280	119	20	decade	decade	NOUN
admet-280	119	21	[	[	X
admet-280	119	22	15	15	NUM
admet-280	119	23	]	]	PUNCT
admet-280	119	24	.	.	PUNCT
admet-280	120	1	this	this	PRON
admet-280	120	2	has	have	AUX
admet-280	120	3	made	make	VERB
admet-280	120	4	them	they	PRON
admet-280	120	5	some	some	PRON
admet-280	120	6	of	of	ADP
admet-280	120	7	the	the	DET
admet-280	120	8	most	most	ADV
admet-280	120	9	widely	widely	ADV
admet-280	120	10	used	use	VERB
admet-280	120	11	hesc	hesc	NOUN
admet-280	120	12	lines	line	NOUN
admet-280	120	13	in	in	ADP
admet-280	120	14	research	research	NOUN
admet-280	120	15	,	,	PUNCT
admet-280	120	16	and	and	CCONJ
admet-280	120	17	in	in	ADP
admet-280	120	18	particular	particular	ADJ
admet-280	120	19	the	the	DET
admet-280	120	20	most	most	ADV
admet-280	120	21	commonly	commonly	ADV
admet-280	120	22	used	use	VERB
admet-280	120	23	hesc	hesc	NOUN
admet-280	120	24	lines	line	NOUN
admet-280	120	25	in	in	ADP
admet-280	120	26	scdh	scdh	NOUN
admet-280	120	27	research	research	NOUN
admet-280	120	28	,	,	PUNCT
admet-280	120	29	specifically	specifically	ADV
admet-280	120	30	the	the	DET
admet-280	120	31	h1	h1	ADJ
admet-280	120	32	and	and	CCONJ
admet-280	120	33	h9	h9	NOUN
admet-280	120	34	lines	line	NOUN
admet-280	120	35	[	[	X
admet-280	120	36	11	11	NUM
admet-280	120	37	,	,	PUNCT
admet-280	120	38	16	16	NUM
admet-280	120	39	-	-	SYM
admet-280	120	40	35	35	NUM
admet-280	120	41	]	]	PUNCT
admet-280	120	42	.	.	PUNCT
admet-280	121	1	to	to	PART
admet-280	121	2	be	be	AUX
admet-280	121	3	useful	useful	ADJ
admet-280	121	4	in	in	ADP
admet-280	121	5	preclinical	preclinical	ADJ
admet-280	121	6	drug	drug	NOUN
admet-280	121	7	metabolism	metabolism	NOUN
admet-280	121	8	and	and	CCONJ
admet-280	121	9	toxicity	toxicity	NOUN
admet-280	121	10	screening	screening	NOUN
admet-280	121	11	,	,	PUNCT
admet-280	121	12	scdhs	scdhs	PROPN
admet-280	121	13	must	must	AUX
admet-280	121	14	demonstrate	demonstrate	VERB
admet-280	121	15	consistent	consistent	ADJ
admet-280	121	16	and	and	CCONJ
admet-280	121	17	reproducible	reproducible	ADJ
admet-280	121	18	activity	activity	NOUN
admet-280	121	19	of	of	ADP
admet-280	121	20	drug	drug	NOUN
admet-280	121	21	metabolism	metabolism	NOUN
admet-280	121	22	proteins	protein	NOUN
admet-280	121	23	,	,	PUNCT
admet-280	121	24	in	in	ADP
admet-280	121	25	particular	particular	ADJ
admet-280	121	26	the	the	DET
admet-280	121	27	oxidative	oxidative	ADJ
admet-280	121	28	cyp	cyp	ADJ
admet-280	121	29	enzymes	enzyme	NOUN
admet-280	121	30	.	.	PUNCT
admet-280	122	1	in	in	ADP
admet-280	122	2	addition	addition	NOUN
admet-280	122	3	,	,	PUNCT
admet-280	122	4	it	it	PRON
admet-280	122	5	would	would	AUX
admet-280	122	6	be	be	AUX
admet-280	122	7	ideal	ideal	ADJ
admet-280	122	8	if	if	SCONJ
admet-280	122	9	scdhs	scdhs	ADV
admet-280	122	10	demonstrate	demonstrate	VERB
admet-280	122	11	metabolic	metabolic	NOUN
admet-280	122	12	activities	activity	NOUN
admet-280	122	13	comparable	comparable	ADJ
admet-280	122	14	to	to	ADP
admet-280	122	15	human	human	ADJ
admet-280	122	16	primary	primary	ADJ
admet-280	122	17	hepatocytes	hepatocyte	NOUN
admet-280	122	18	.	.	PUNCT
admet-280	123	1	we	we	PRON
admet-280	123	2	sought	seek	VERB
admet-280	123	3	to	to	PART
admet-280	123	4	further	far	ADV
admet-280	123	5	investigate	investigate	VERB
admet-280	123	6	the	the	DET
admet-280	123	7	state	state	NOUN
admet-280	123	8	of	of	ADP
admet-280	123	9	scdhs	scdhs	NOUN
admet-280	123	10	as	as	SCONJ
admet-280	123	11	they	they	PRON
admet-280	123	12	compare	compare	VERB
admet-280	123	13	to	to	ADP
admet-280	123	14	cryopreserved	cryopreserve	VERB
admet-280	123	15	human	human	ADJ
admet-280	123	16	hepatocytes	hepatocyte	NOUN
admet-280	123	17	,	,	PUNCT
admet-280	123	18	with	with	ADP
admet-280	123	19	emphasis	emphasis	NOUN
admet-280	123	20	on	on	ADP
admet-280	123	21	the	the	DET
admet-280	123	22	expression	expression	NOUN
admet-280	123	23	and	and	CCONJ
admet-280	123	24	functional	functional	ADJ
admet-280	123	25	capacity	capacity	NOUN
admet-280	123	26	of	of	ADP
admet-280	123	27	drug	drug	NOUN
admet-280	123	28	-	-	PUNCT
admet-280	123	29	metabolizing	metabolize	VERB
admet-280	123	30	enzymes	enzyme	NOUN
admet-280	123	31	.	.	PUNCT
admet-280	124	1	in	in	ADP
admet-280	124	2	addition	addition	NOUN
admet-280	124	3	,	,	PUNCT
admet-280	124	4	when	when	SCONJ
admet-280	124	5	evaluating	evaluate	VERB
admet-280	124	6	cyp	cyp	ADJ
admet-280	124	7	activity	activity	NOUN
admet-280	124	8	versus	versus	ADP
admet-280	124	9	primary	primary	ADJ
admet-280	124	10	hepatocytes	hepatocyte	NOUN
admet-280	124	11	,	,	PUNCT
admet-280	124	12	it	it	PRON
admet-280	124	13	’s	’	VERB
admet-280	124	14	important	important	ADJ
admet-280	124	15	to	to	PART
admet-280	124	16	take	take	VERB
admet-280	124	17	pharmacogenetic	pharmacogenetic	ADJ
admet-280	124	18	variability	variability	NOUN
admet-280	124	19	into	into	ADP
admet-280	124	20	account	account	NOUN
admet-280	124	21	.	.	PUNCT
admet-280	125	1	to	to	PART
admet-280	125	2	demonstrate	demonstrate	VERB
admet-280	125	3	the	the	DET
admet-280	125	4	utility	utility	NOUN
admet-280	125	5	of	of	ADP
admet-280	125	6	scdhs	scdhs	NOUN
admet-280	125	7	in	in	ADP
admet-280	125	8	pharmacogenetic	pharmacogenetic	ADJ
admet-280	125	9	predictive	predictive	ADJ
admet-280	125	10	screening	screening	NOUN
admet-280	125	11	,	,	PUNCT
admet-280	125	12	we	we	PRON
admet-280	125	13	also	also	ADV
admet-280	125	14	sought	seek	VERB
admet-280	125	15	to	to	PART
admet-280	125	16	genetically	genetically	ADV
admet-280	125	17	profile	profile	VERB
admet-280	125	18	the	the	DET
admet-280	125	19	commonly	commonly	ADV
admet-280	125	20	used	use	VERB
admet-280	125	21	wicell	wicell	PROPN
admet-280	125	22	®	®	NOUN
admet-280	125	23	hesc	hesc	NOUN
admet-280	125	24	lines	line	NOUN
admet-280	125	25	,	,	PUNCT
admet-280	125	26	focusing	focus	VERB
admet-280	125	27	on	on	ADP
admet-280	125	28	cyp2d6	cyp2d6	NOUN
admet-280	125	29	in	in	ADP
admet-280	125	30	our	our	PRON
admet-280	125	31	analysis	analysis	NOUN
admet-280	125	32	.	.	PUNCT
admet-280	126	1	hepatocyte	hepatocyte	NOUN
admet-280	126	2	differentiation	differentiation	NOUN
admet-280	126	3	and	and	CCONJ
admet-280	126	4	gene	gene	NOUN
admet-280	126	5	expression	expression	NOUN
admet-280	126	6	hepatocyte	hepatocyte	NOUN
admet-280	126	7	differentiation	differentiation	NOUN
admet-280	126	8	was	be	AUX
admet-280	126	9	performed	perform	VERB
admet-280	126	10	using	use	VERB
admet-280	126	11	a	a	DET
admet-280	126	12	published	publish	VERB
admet-280	126	13	protocol	protocol	NOUN
admet-280	126	14	[	[	X
admet-280	126	15	11	11	NUM
admet-280	126	16	,	,	PUNCT
admet-280	126	17	12	12	NUM
admet-280	126	18	]	]	PUNCT
admet-280	126	19	.	.	PUNCT
admet-280	127	1	briefly	briefly	NOUN
admet-280	127	2	,	,	PUNCT
admet-280	127	3	this	this	DET
admet-280	127	4	protocol	protocol	NOUN
admet-280	127	5	is	be	AUX
admet-280	127	6	broken	break	VERB
admet-280	127	7	into	into	ADP
admet-280	127	8	three	three	NUM
admet-280	127	9	stages	stage	NOUN
admet-280	127	10	to	to	PART
admet-280	127	11	induce	induce	VERB
admet-280	127	12	hepatocyte	hepatocyte	ADJ
admet-280	127	13	differentiation	differentiation	NOUN
admet-280	127	14	:	:	PUNCT
admet-280	127	15	first	first	ADV
admet-280	127	16	the	the	DET
admet-280	127	17	priming	prime	VERB
admet-280	127	18	stage	stage	NOUN
admet-280	127	19	primes	prime	VERB
admet-280	127	20	the	the	DET
admet-280	127	21	cells	cell	NOUN
admet-280	127	22	to	to	ADP
admet-280	127	23	the	the	DET
admet-280	127	24	definitive	definitive	ADJ
admet-280	127	25	endoderm	endoderm	NOUN
admet-280	127	26	lineage	lineage	NOUN
admet-280	127	27	[	[	X
admet-280	127	28	11	11	NUM
admet-280	127	29	,	,	PUNCT
admet-280	127	30	33	33	NUM
admet-280	127	31	,	,	PUNCT
admet-280	127	32	36	36	NUM
admet-280	127	33	]	]	PUNCT
admet-280	127	34	,	,	PUNCT
admet-280	127	35	secondly	secondly	ADV
admet-280	127	36	the	the	DET
admet-280	127	37	differentiation	differentiation	NOUN
admet-280	127	38	stage	stage	NOUN
admet-280	127	39	induces	induce	VERB
admet-280	127	40	hepatocyte	hepatocyte	ADJ
admet-280	127	41	differentiation	differentiation	NOUN
admet-280	127	42	to	to	PART
admet-280	127	43	form	form	VERB
admet-280	127	44	hepatoblast	hepatoblast	ADJ
admet-280	127	45	cells	cell	NOUN
admet-280	127	46	,	,	PUNCT
admet-280	127	47	and	and	CCONJ
admet-280	127	48	finally	finally	ADV
admet-280	127	49	the	the	DET
admet-280	127	50	maturation	maturation	NOUN
admet-280	127	51	stage	stage	NOUN
admet-280	127	52	allows	allow	VERB
admet-280	127	53	for	for	ADP
admet-280	127	54	final	final	ADJ
admet-280	127	55	differentiation	differentiation	NOUN
admet-280	127	56	and	and	CCONJ
admet-280	127	57	maturation	maturation	NOUN
admet-280	127	58	of	of	ADP
admet-280	127	59	the	the	DET
admet-280	127	60	resulting	result	VERB
admet-280	127	61	hepatocytes	hepatocyte	NOUN
admet-280	127	62	.	.	PUNCT
admet-280	128	1	this	this	DET
admet-280	128	2	differentiation	differentiation	NOUN
admet-280	128	3	protocol	protocol	NOUN
admet-280	128	4	yielded	yield	VERB
admet-280	128	5	scdhs	scdhs	ADV
admet-280	128	6	which	which	PRON
admet-280	128	7	morphologically	morphologically	ADV
admet-280	128	8	resemble	resemble	VERB
admet-280	128	9	hepatocytes	hepatocyte	NOUN
admet-280	128	10	by	by	ADP
admet-280	128	11	displaying	display	VERB
admet-280	128	12	the	the	DET
admet-280	128	13	hepatocyte	hepatocyte	NOUN
admet-280	128	14	cuboidal	cuboidal	ADJ
admet-280	128	15	morphology	morphology	NOUN
admet-280	128	16	and	and	CCONJ
admet-280	128	17	bi	bi	ADJ
admet-280	128	18	-	-	ADJ
admet-280	128	19	nucleated	nucleated	ADJ
admet-280	128	20	cells	cell	NOUN
admet-280	128	21	(	(	PUNCT
admet-280	128	22	figure	figure	NOUN
admet-280	128	23	1a	1a	NOUN
admet-280	128	24	and	and	CCONJ
admet-280	128	25	b	b	NOUN
admet-280	128	26	)	)	PUNCT
admet-280	128	27	.	.	PUNCT
admet-280	129	1	in	in	ADP
admet-280	129	2	addition	addition	NOUN
admet-280	129	3	,	,	PUNCT
admet-280	129	4	the	the	DET
admet-280	129	5	scdhs	scdhs	NOUN
admet-280	129	6	were	be	AUX
admet-280	129	7	immunocytochemically	immunocytochemically	ADV
admet-280	129	8	positive	positive	ADJ
admet-280	129	9	for	for	ADP
admet-280	129	10	afp	afp	NOUN
admet-280	129	11	,	,	PUNCT
admet-280	129	12	albumin	albumin	NOUN
admet-280	129	13	,	,	PUNCT
admet-280	129	14	hnf4α	hnf4α	PROPN
admet-280	129	15	and	and	CCONJ
admet-280	129	16	cyp3a	cyp3a	NOUN
admet-280	129	17	(	(	PUNCT
admet-280	129	18	figure	figure	NOUN
admet-280	129	19	1c	1c	NOUN
admet-280	129	20	)	)	PUNCT
admet-280	129	21	.	.	PUNCT
admet-280	130	1	positive	positive	ADJ
admet-280	130	2	immunocytochemical	immunocytochemical	ADJ
admet-280	130	3	staining	staining	NOUN
admet-280	130	4	was	be	AUX
admet-280	130	5	uniform	uniform	ADJ
admet-280	130	6	across	across	ADP
admet-280	130	7	the	the	DET
admet-280	130	8	wells	well	NOUN
admet-280	130	9	with	with	ADP
admet-280	130	10	the	the	DET
admet-280	130	11	exception	exception	NOUN
admet-280	130	12	of	of	ADP
admet-280	130	13	colonies	colony	NOUN
admet-280	130	14	of	of	ADP
admet-280	130	15	cells	cell	NOUN
admet-280	130	16	that	that	PRON
admet-280	130	17	failed	fail	VERB
admet-280	130	18	to	to	PART
admet-280	130	19	differentiate	differentiate	VERB
admet-280	130	20	.	.	PUNCT
admet-280	131	1	in	in	ADP
admet-280	131	2	order	order	NOUN
admet-280	131	3	to	to	PART
admet-280	131	4	evaluate	evaluate	VERB
admet-280	131	5	the	the	DET
admet-280	131	6	maturity	maturity	NOUN
admet-280	131	7	level	level	NOUN
admet-280	131	8	of	of	ADP
admet-280	131	9	scdhs	scdhs	NOUN
admet-280	131	10	and	and	CCONJ
admet-280	131	11	gain	gain	VERB
admet-280	131	12	a	a	DET
admet-280	131	13	better	well	ADJ
admet-280	131	14	understanding	understanding	NOUN
admet-280	131	15	of	of	ADP
admet-280	131	16	their	their	PRON
admet-280	131	17	potential	potential	ADJ
admet-280	131	18	utility	utility	NOUN
admet-280	131	19	in	in	ADP
admet-280	131	20	preclinical	preclinical	ADJ
admet-280	131	21	drug	drug	NOUN
admet-280	131	22	metabolism	metabolism	NOUN
admet-280	131	23	screens	screen	NOUN
admet-280	131	24	,	,	PUNCT
admet-280	131	25	gene	gene	NOUN
admet-280	131	26	expression	expression	NOUN
admet-280	131	27	profiling	profiling	NOUN
admet-280	131	28	of	of	ADP
admet-280	131	29	select	select	ADJ
admet-280	131	30	pluripotency	pluripotency	NOUN
admet-280	131	31	markers	marker	NOUN
admet-280	131	32	,	,	PUNCT
admet-280	131	33	hepatocytes	hepatocytes	PROPN
admet-280	131	34	markers	marker	NOUN
admet-280	131	35	,	,	PUNCT
admet-280	131	36	transcription	transcription	NOUN
admet-280	131	37	factors	factor	NOUN
admet-280	131	38	,	,	PUNCT
admet-280	131	39	drug	drug	NOUN
admet-280	131	40	-	-	PUNCT
admet-280	131	41	metabolizing	metabolize	VERB
admet-280	131	42	enzymes	enzyme	NOUN
admet-280	131	43	and	and	CCONJ
admet-280	131	44	transporters	transporter	NOUN
admet-280	131	45	was	be	AUX
admet-280	131	46	done	do	VERB
admet-280	131	47	.	.	PUNCT
admet-280	132	1	this	this	DET
admet-280	132	2	expression	expression	NOUN
admet-280	132	3	profiling	profiling	NOUN
admet-280	132	4	was	be	AUX
admet-280	132	5	performed	perform	VERB
admet-280	132	6	for	for	ADP
admet-280	132	7	scdhs	scdhs	NOUN
admet-280	132	8	at	at	ADP
admet-280	132	9	each	each	DET
admet-280	132	10	stage	stage	NOUN
admet-280	132	11	of	of	ADP
admet-280	132	12	differentiation	differentiation	NOUN
admet-280	132	13	,	,	PUNCT
admet-280	132	14	hescs	hesc	NOUN
admet-280	132	15	,	,	PUNCT
admet-280	132	16	cryopreserved	cryopreserved	ADJ
admet-280	132	17	hepatocytes	hepatocyte	NOUN
admet-280	132	18	,	,	PUNCT
admet-280	132	19	heparg	heparg	NOUN
admet-280	132	20	cells	cell	NOUN
admet-280	132	21	,	,	PUNCT
admet-280	132	22	human	human	ADJ
admet-280	132	23	fetal	fetal	ADJ
admet-280	132	24	liver	liver	NOUN
admet-280	132	25	tissue	tissue	NOUN
admet-280	132	26	and	and	CCONJ
admet-280	132	27	human	human	ADJ
admet-280	132	28	adult	adult	NOUN
admet-280	132	29	liver	liver	NOUN
admet-280	132	30	tissue	tissue	NOUN
admet-280	132	31	.	.	PUNCT
admet-280	133	1	heparg	heparg	NOUN
admet-280	133	2	cells	cell	NOUN
admet-280	133	3	are	be	AUX
admet-280	133	4	a	a	DET
admet-280	133	5	cell	cell	NOUN
admet-280	133	6	line	line	NOUN
admet-280	133	7	derived	derive	VERB
admet-280	133	8	from	from	ADP
admet-280	133	9	a	a	DET
admet-280	133	10	human	human	ADJ
admet-280	133	11	adult	adult	NOUN
admet-280	133	12	hepatocarcinoma	hepatocarcinoma	NOUN
admet-280	133	13	patient	patient	NOUN
admet-280	133	14	,	,	PUNCT
admet-280	133	15	which	which	PRON
admet-280	133	16	resemble	resemble	VERB
admet-280	133	17	the	the	DET
admet-280	133	18	bi	bi	ADJ
admet-280	133	19	-	-	ADJ
admet-280	133	20	potential	potential	ADJ
admet-280	133	21	hepatoblast	hepatoblast	ADJ
admet-280	133	22	cell	cell	NOUN
admet-280	133	23	voellinger	voellinger	NOUN
admet-280	133	24	and	and	CCONJ
admet-280	133	25	kelly	kelly	PROPN
admet-280	133	26	admet	admet	PROPN
admet-280	133	27	&	&	CCONJ
admet-280	133	28	dmpk	dmpk	PROPN
admet-280	133	29	4(2	4(2	NUM
admet-280	133	30	)	)	PUNCT
admet-280	133	31	(	(	PUNCT
admet-280	133	32	2016	2016	NUM
admet-280	133	33	)	)	PUNCT
admet-280	133	34	62	62	NUM
admet-280	133	35	-	-	SYM
admet-280	133	36	83	83	NUM
admet-280	133	37	68	68	NUM
admet-280	134	1	[	[	X
admet-280	134	2	37	37	NUM
admet-280	134	3	-	-	SYM
admet-280	134	4	39	39	NUM
admet-280	134	5	]	]	PUNCT
admet-280	134	6	.	.	PUNCT
admet-280	135	1	these	these	DET
admet-280	135	2	cells	cell	NOUN
admet-280	135	3	can	can	AUX
admet-280	135	4	be	be	AUX
admet-280	135	5	cultured	cultured	ADJ
admet-280	135	6	in	in	ADP
admet-280	135	7	their	their	PRON
admet-280	135	8	hepatoblast	hepatoblast	NOUN
admet-280	135	9	,	,	PUNCT
admet-280	135	10	or	or	CCONJ
admet-280	135	11	undifferentiated	undifferentiated	ADJ
admet-280	135	12	state	state	NOUN
admet-280	135	13	,	,	PUNCT
admet-280	135	14	and	and	CCONJ
admet-280	135	15	then	then	ADV
admet-280	135	16	undergo	undergo	VERB
admet-280	135	17	a	a	DET
admet-280	135	18	differentiation	differentiation	NOUN
admet-280	135	19	process	process	NOUN
admet-280	135	20	to	to	PART
admet-280	135	21	form	form	VERB
admet-280	135	22	both	both	DET
admet-280	135	23	biliary	biliary	ADJ
admet-280	135	24	epithelial	epithelial	ADJ
admet-280	135	25	cells	cell	NOUN
admet-280	135	26	and	and	CCONJ
admet-280	135	27	hepatocytes	hepatocyte	NOUN
admet-280	136	1	[	[	X
admet-280	136	2	37	37	NUM
admet-280	136	3	-	-	SYM
admet-280	136	4	39	39	NUM
admet-280	136	5	]	]	PUNCT
admet-280	136	6	.	.	PUNCT
admet-280	137	1	heparg	heparg	NOUN
admet-280	137	2	cells	cell	NOUN
admet-280	137	3	express	express	VERB
admet-280	137	4	many	many	ADJ
admet-280	137	5	of	of	ADP
admet-280	137	6	the	the	DET
admet-280	137	7	drug	drug	NOUN
admet-280	137	8	-	-	PUNCT
admet-280	137	9	metabolizing	metabolize	VERB
admet-280	137	10	enzymes	enzyme	NOUN
admet-280	137	11	and	and	CCONJ
admet-280	137	12	more	more	ADV
admet-280	137	13	closely	closely	ADV
admet-280	137	14	resemble	resemble	VERB
admet-280	137	15	primary	primary	ADJ
admet-280	137	16	hepatocytes	hepatocyte	NOUN
admet-280	137	17	than	than	ADP
admet-280	137	18	the	the	DET
admet-280	137	19	commonly	commonly	ADV
admet-280	137	20	used	use	VERB
admet-280	137	21	hepg2	hepg2	NOUN
admet-280	137	22	cells	cell	NOUN
admet-280	137	23	[	[	X
admet-280	137	24	39	39	NUM
admet-280	137	25	]	]	PUNCT
admet-280	137	26	.	.	PUNCT
admet-280	138	1	to	to	PART
admet-280	138	2	determine	determine	VERB
admet-280	138	3	if	if	SCONJ
admet-280	138	4	scdhs	scdhs	ADJ
admet-280	138	5	retain	retain	VERB
admet-280	138	6	stem	stem	NOUN
admet-280	138	7	cell	cell	NOUN
admet-280	138	8	characteristics	characteristic	NOUN
admet-280	138	9	,	,	PUNCT
admet-280	138	10	the	the	DET
admet-280	138	11	pluripotency	pluripotency	NOUN
admet-280	138	12	markers	marker	NOUN
admet-280	138	13	nanog	nanog	PROPN
admet-280	138	14	,	,	PUNCT
admet-280	138	15	oct4	oct4	PROPN
admet-280	138	16	and	and	CCONJ
admet-280	138	17	sox2	sox2	NOUN
admet-280	138	18	were	be	AUX
admet-280	138	19	evaluated	evaluate	VERB
admet-280	138	20	.	.	PUNCT
admet-280	139	1	all	all	DET
admet-280	139	2	results	result	NOUN
admet-280	139	3	are	be	AUX
admet-280	139	4	reported	report	VERB
admet-280	139	5	as	as	ADP
admet-280	139	6	fold	fold	ADJ
admet-280	139	7	change	change	NOUN
admet-280	139	8	compared	compare	VERB
admet-280	139	9	to	to	ADP
admet-280	139	10	differentiated	differentiated	ADJ
admet-280	139	11	heparg	heparg	NOUN
admet-280	139	12	cells	cell	NOUN
admet-280	139	13	,	,	PUNCT
admet-280	139	14	with	with	ADP
admet-280	139	15	gusb	gusb	PROPN
admet-280	139	16	as	as	ADP
admet-280	139	17	the	the	DET
admet-280	139	18	housekeeping	housekeeping	NOUN
admet-280	139	19	gene	gene	NOUN
admet-280	139	20	.	.	PUNCT
admet-280	140	1	from	from	ADP
admet-280	140	2	the	the	DET
admet-280	140	3	gene	gene	NOUN
admet-280	140	4	expression	expression	NOUN
admet-280	140	5	profiling	profiling	NOUN
admet-280	140	6	,	,	PUNCT
admet-280	140	7	nanog	nanog	PROPN
admet-280	140	8	,	,	PUNCT
admet-280	140	9	oct4	oct4	PROPN
admet-280	140	10	,	,	PUNCT
admet-280	140	11	and	and	CCONJ
admet-280	140	12	sox2	sox2	NOUN
admet-280	140	13	expression	expression	NOUN
admet-280	140	14	dropped	drop	VERB
admet-280	140	15	as	as	ADP
admet-280	140	16	differentiation	differentiation	NOUN
admet-280	140	17	progressed	progress	VERB
admet-280	140	18	from	from	ADP
admet-280	140	19	stem	stem	NOUN
admet-280	140	20	cell	cell	NOUN
admet-280	140	21	to	to	PART
admet-280	140	22	scdhs	scdhs	VERB
admet-280	140	23	(	(	PUNCT
admet-280	140	24	figure	figure	NOUN
admet-280	140	25	2	2	NUM
admet-280	140	26	)	)	PUNCT
admet-280	140	27	,	,	PUNCT
admet-280	140	28	suggesting	suggest	VERB
admet-280	140	29	the	the	DET
admet-280	140	30	cells	cell	NOUN
admet-280	140	31	are	be	AUX
admet-280	140	32	undergoing	undergo	VERB
admet-280	140	33	a	a	DET
admet-280	140	34	differentiation	differentiation	NOUN
admet-280	140	35	process	process	NOUN
admet-280	140	36	and	and	CCONJ
admet-280	140	37	are	be	AUX
admet-280	140	38	not	not	PART
admet-280	140	39	retaining	retain	VERB
admet-280	140	40	their	their	PRON
admet-280	140	41	pluripotency	pluripotency	NOUN
admet-280	140	42	.	.	PUNCT
admet-280	141	1	notably	notably	ADV
admet-280	141	2	,	,	PUNCT
admet-280	141	3	expression	expression	NOUN
admet-280	141	4	of	of	ADP
admet-280	141	5	nanog	nanog	PROPN
admet-280	141	6	and	and	CCONJ
admet-280	141	7	oct4	oct4	PROPN
admet-280	141	8	in	in	ADP
admet-280	141	9	scdhs	scdhs	PROPN
admet-280	141	10	was	be	AUX
admet-280	141	11	similar	similar	ADJ
admet-280	141	12	to	to	ADP
admet-280	141	13	expression	expression	NOUN
admet-280	141	14	in	in	ADP
admet-280	141	15	differentiated	differentiated	ADJ
admet-280	141	16	heparg	heparg	NOUN
admet-280	141	17	cells	cell	NOUN
admet-280	141	18	,	,	PUNCT
admet-280	141	19	which	which	PRON
admet-280	141	20	was	be	AUX
admet-280	141	21	below	below	ADP
admet-280	141	22	the	the	DET
admet-280	141	23	level	level	NOUN
admet-280	141	24	of	of	ADP
admet-280	141	25	expression	expression	NOUN
admet-280	141	26	in	in	ADP
admet-280	141	27	fetal	fetal	ADJ
admet-280	141	28	liver	liver	NOUN
admet-280	141	29	tissue	tissue	NOUN
admet-280	141	30	(	(	PUNCT
admet-280	141	31	figure	figure	NOUN
admet-280	141	32	2	2	NUM
admet-280	141	33	)	)	PUNCT
admet-280	141	34	.	.	PUNCT
admet-280	142	1	sox2	sox2	NOUN
admet-280	142	2	expression	expression	NOUN
admet-280	142	3	in	in	ADP
admet-280	142	4	scdhs	scdhs	PROPN
admet-280	142	5	was	be	AUX
admet-280	142	6	more	more	ADV
admet-280	142	7	variable	variable	ADJ
admet-280	142	8	between	between	ADP
admet-280	142	9	the	the	DET
admet-280	142	10	different	different	ADJ
admet-280	142	11	cell	cell	NOUN
admet-280	142	12	lines	line	NOUN
admet-280	142	13	,	,	PUNCT
admet-280	142	14	and	and	CCONJ
admet-280	142	15	ranged	range	VERB
admet-280	142	16	from	from	ADP
admet-280	142	17	0.4to	0.4to	NUM
admet-280	142	18	15	15	NUM
admet-280	142	19	-	-	NOUN
admet-280	142	20	fold	fold	NOUN
admet-280	142	21	compared	compare	VERB
admet-280	142	22	to	to	ADP
admet-280	142	23	differentiated	differentiated	ADJ
admet-280	142	24	heparg	heparg	NOUN
admet-280	142	25	cells	cell	NOUN
admet-280	142	26	,	,	PUNCT
admet-280	142	27	while	while	SCONJ
admet-280	142	28	sox2	sox2	NOUN
admet-280	142	29	expression	expression	NOUN
admet-280	142	30	in	in	ADP
admet-280	142	31	fetal	fetal	ADJ
admet-280	142	32	liver	liver	NOUN
admet-280	142	33	tissue	tissue	NOUN
admet-280	142	34	ranged	range	VERB
admet-280	142	35	from	from	ADP
admet-280	142	36	0.4to	0.4to	NUM
admet-280	142	37	7	7	NUM
admet-280	142	38	-	-	NOUN
admet-280	142	39	fold	fold	NOUN
admet-280	142	40	compared	compare	VERB
admet-280	142	41	to	to	ADP
admet-280	142	42	differentiated	differentiated	ADJ
admet-280	142	43	heparg	heparg	NOUN
admet-280	142	44	cells	cell	NOUN
admet-280	142	45	.	.	PUNCT
admet-280	143	1	expression	expression	NOUN
admet-280	143	2	of	of	ADP
admet-280	143	3	all	all	DET
admet-280	143	4	three	three	NUM
admet-280	143	5	pluripotency	pluripotency	ADJ
admet-280	143	6	markers	marker	NOUN
admet-280	143	7	was	be	AUX
admet-280	143	8	low	low	ADJ
admet-280	143	9	in	in	ADP
admet-280	143	10	the	the	DET
admet-280	143	11	adult	adult	NOUN
admet-280	143	12	human	human	ADJ
admet-280	143	13	liver	liver	NOUN
admet-280	143	14	tissues	tissue	NOUN
admet-280	143	15	evaluated	evaluate	VERB
admet-280	143	16	.	.	PUNCT
admet-280	144	1	figure	figure	VERB
admet-280	144	2	1	1	NUM
admet-280	144	3	.	.	PUNCT
admet-280	145	1	scdh	scdh	VERB
admet-280	145	2	photomicrographs	photomicrograph	NOUN
admet-280	145	3	and	and	CCONJ
admet-280	145	4	immunocytochemistry	immunocytochemistry	NOUN
admet-280	145	5	.	.	PUNCT
admet-280	146	1	(	(	PUNCT
admet-280	146	2	a	a	DET
admet-280	146	3	,	,	PUNCT
admet-280	146	4	b	b	NOUN
admet-280	146	5	)	)	PUNCT
admet-280	146	6	photomicrographs	photomicrograph	NOUN
admet-280	146	7	depicting	depict	VERB
admet-280	146	8	h1	h1	PROPN
admet-280	146	9	and	and	CCONJ
admet-280	146	10	h9	h9	NOUN
admet-280	146	11	scdhs	scdhs	PROPN
admet-280	146	12	,	,	PUNCT
admet-280	146	13	respectively	respectively	ADV
admet-280	146	14	,	,	PUNCT
admet-280	146	15	at	at	ADP
admet-280	146	16	each	each	DET
admet-280	146	17	stage	stage	NOUN
admet-280	146	18	of	of	ADP
admet-280	146	19	differentiation	differentiation	NOUN
admet-280	146	20	;	;	PUNCT
admet-280	146	21	hesc	hesc	NOUN
admet-280	146	22	,	,	PUNCT
admet-280	146	23	definitive	definitive	ADJ
admet-280	146	24	endoderm	endoderm	NOUN
admet-280	146	25	(	(	PUNCT
admet-280	146	26	de	de	ADJ
admet-280	146	27	)	)	PUNCT
admet-280	146	28	,	,	PUNCT
admet-280	146	29	hepatoblast	hepatoblast	NOUN
admet-280	146	30	,	,	PUNCT
admet-280	146	31	and	and	CCONJ
admet-280	146	32	hepatocyte	hepatocyte	NOUN
admet-280	146	33	.	.	PUNCT
admet-280	147	1	(	(	PUNCT
admet-280	147	2	c	c	X
admet-280	147	3	)	)	PUNCT
admet-280	147	4	immunocytochemistry	immunocytochemistry	NOUN
admet-280	147	5	results	result	VERB
admet-280	147	6	for	for	ADP
admet-280	147	7	albumin	albumin	NOUN
admet-280	147	8	,	,	PUNCT
admet-280	147	9	α	α	NOUN
admet-280	147	10	-	-	PUNCT
admet-280	147	11	fetoprotein	fetoprotein	ADJ
admet-280	147	12	(	(	PUNCT
admet-280	147	13	afp	afp	NOUN
admet-280	147	14	)	)	PUNCT
admet-280	147	15	,	,	PUNCT
admet-280	147	16	hepatocyte	hepatocyte	NOUN
admet-280	147	17	nuclear	nuclear	ADJ
admet-280	147	18	factor	factor	NOUN
admet-280	147	19	4α	4α	NOUN
admet-280	147	20	(	(	PUNCT
admet-280	147	21	hnf4α	hnf4α	PROPN
admet-280	147	22	)	)	PUNCT
admet-280	147	23	,	,	PUNCT
admet-280	147	24	and	and	CCONJ
admet-280	147	25	cyp3a	cyp3a	NOUN
admet-280	147	26	on	on	ADP
admet-280	147	27	day	day	NOUN
admet-280	147	28	17	17	NUM
admet-280	147	29	scdhs	scdhs	ADJ
admet-280	147	30	.	.	PUNCT
admet-280	148	1	positive	positive	ADJ
admet-280	148	2	staining	staining	NOUN
admet-280	148	3	is	be	AUX
admet-280	148	4	indicated	indicate	VERB
admet-280	148	5	in	in	ADP
admet-280	148	6	green	green	ADJ
admet-280	148	7	,	,	PUNCT
admet-280	148	8	dapi	dapi	PROPN
admet-280	148	9	was	be	AUX
admet-280	148	10	used	use	VERB
admet-280	148	11	to	to	PART
admet-280	148	12	stain	stain	NOUN
admet-280	148	13	nuclei	nucleus	NOUN
admet-280	148	14	,	,	PUNCT
admet-280	148	15	shown	show	VERB
admet-280	148	16	in	in	ADP
admet-280	148	17	blue	blue	ADJ
admet-280	148	18	.	.	PUNCT
admet-280	149	1	a	a	DET
admet-280	149	2	similar	similar	ADJ
admet-280	149	3	expression	expression	NOUN
admet-280	149	4	pattern	pattern	NOUN
admet-280	149	5	was	be	AUX
admet-280	149	6	observed	observe	VERB
admet-280	149	7	for	for	ADP
admet-280	149	8	three	three	NUM
admet-280	149	9	hepatocyte	hepatocyte	NOUN
admet-280	149	10	markers	marker	NOUN
admet-280	149	11	(	(	PUNCT
admet-280	149	12	afp	afp	PROPN
admet-280	149	13	,	,	PUNCT
admet-280	149	14	alb	alb	PROPN
admet-280	149	15	and	and	CCONJ
admet-280	149	16	hnf4α	hnf4α	NOUN
admet-280	149	17	)	)	PUNCT
admet-280	149	18	,	,	PUNCT
admet-280	149	19	with	with	ADP
admet-280	149	20	expression	expression	NOUN
admet-280	149	21	increasing	increase	VERB
admet-280	149	22	from	from	ADP
admet-280	149	23	stem	stem	NOUN
admet-280	149	24	cells	cell	NOUN
admet-280	149	25	through	through	ADP
admet-280	149	26	differentiation	differentiation	NOUN
admet-280	149	27	to	to	PART
admet-280	149	28	scdhs	scdhs	VERB
admet-280	149	29	(	(	PUNCT
admet-280	149	30	figure	figure	NOUN
admet-280	149	31	2	2	NUM
admet-280	149	32	)	)	PUNCT
admet-280	149	33	.	.	PUNCT
admet-280	150	1	for	for	ADP
admet-280	150	2	albumin	albumin	NOUN
admet-280	150	3	,	,	PUNCT
admet-280	150	4	expression	expression	NOUN
admet-280	150	5	in	in	ADP
admet-280	150	6	scdhs	scdhs	PROPN
admet-280	150	7	was	be	AUX
admet-280	150	8	lower	low	ADJ
admet-280	150	9	than	than	ADP
admet-280	150	10	the	the	DET
admet-280	150	11	expression	expression	NOUN
admet-280	150	12	in	in	ADP
admet-280	150	13	differentiated	differentiated	ADJ
admet-280	150	14	heparg	heparg	NOUN
admet-280	150	15	cells	cell	NOUN
admet-280	150	16	,	,	PUNCT
admet-280	150	17	fetal	fetal	ADJ
admet-280	150	18	and	and	CCONJ
admet-280	150	19	adult	adult	NOUN
admet-280	150	20	liver	liver	NOUN
admet-280	150	21	tissues	tissue	NOUN
admet-280	150	22	.	.	PUNCT
admet-280	151	1	for	for	ADP
admet-280	151	2	hnf4α	hnf4α	NOUN
admet-280	151	3	,	,	PUNCT
admet-280	151	4	expression	expression	NOUN
admet-280	151	5	in	in	ADP
admet-280	151	6	scdhs	scdhs	PROPN
admet-280	151	7	was	be	AUX
admet-280	151	8	comparable	comparable	ADJ
admet-280	151	9	to	to	ADP
admet-280	151	10	expression	expression	NOUN
admet-280	151	11	in	in	ADP
admet-280	151	12	fetal	fetal	ADJ
admet-280	151	13	and	and	CCONJ
admet-280	151	14	adult	adult	NOUN
admet-280	151	15	liver	liver	NOUN
admet-280	151	16	tissues	tissue	NOUN
admet-280	151	17	,	,	PUNCT
admet-280	151	18	though	though	SCONJ
admet-280	151	19	lower	low	ADJ
admet-280	151	20	than	than	ADP
admet-280	151	21	differentiated	differentiated	ADJ
admet-280	151	22	heparg	heparg	NOUN
admet-280	151	23	cells	cell	NOUN
admet-280	151	24	(	(	PUNCT
admet-280	151	25	figure	figure	NOUN
admet-280	151	26	2	2	NUM
admet-280	151	27	)	)	PUNCT
admet-280	151	28	.	.	PUNCT
admet-280	152	1	with	with	ADP
admet-280	152	2	regard	regard	NOUN
admet-280	152	3	to	to	ADP
admet-280	152	4	afp	afp	PROPN
admet-280	152	5	,	,	PUNCT
admet-280	152	6	scdhs	scdhs	PROPN
admet-280	152	7	expressed	express	VERB
admet-280	152	8	afp	afp	NOUN
admet-280	152	9	to	to	ADP
admet-280	152	10	a	a	DET
admet-280	152	11	much	much	ADV
admet-280	152	12	greater	great	ADJ
admet-280	152	13	extent	extent	NOUN
admet-280	152	14	than	than	ADP
admet-280	152	15	differentiated	differentiated	ADJ
admet-280	152	16	heparg	heparg	NOUN
admet-280	152	17	cells	cell	NOUN
admet-280	152	18	,	,	PUNCT
admet-280	152	19	ranging	range	VERB
admet-280	152	20	from	from	ADP
admet-280	152	21	2800to	2800to	ADJ
admet-280	152	22	13000	13000	NUM
admet-280	152	23	-	-	NUM
admet-280	152	24	fold	fold	VERB
admet-280	152	25	higher	high	ADJ
admet-280	152	26	than	than	ADP
admet-280	152	27	heparg	heparg	NOUN
admet-280	152	28	cells	cell	NOUN
admet-280	152	29	(	(	PUNCT
admet-280	152	30	figure	figure	NOUN
admet-280	152	31	2	2	NUM
admet-280	152	32	)	)	PUNCT
admet-280	152	33	.	.	PUNCT
admet-280	153	1	expression	expression	NOUN
admet-280	153	2	of	of	ADP
admet-280	153	3	afp	afp	PROPN
admet-280	153	4	in	in	ADP
admet-280	153	5	fetal	fetal	ADJ
admet-280	153	6	liver	liver	NOUN
admet-280	153	7	tissue	tissue	NOUN
admet-280	153	8	ranged	range	VERB
admet-280	153	9	from	from	ADP
admet-280	153	10	3600to	3600to	PROPN
admet-280	153	11	30000	30000	NUM
admet-280	153	12	-	-	NOUN
admet-280	153	13	fold	fold	VERB
admet-280	153	14	higher	high	ADJ
admet-280	153	15	than	than	ADP
admet-280	153	16	heparg	heparg	NOUN
admet-280	153	17	cells	cell	NOUN
admet-280	153	18	,	,	PUNCT
admet-280	153	19	indicating	indicate	VERB
admet-280	153	20	that	that	SCONJ
admet-280	153	21	scdhs	scdhs	PROPN
admet-280	153	22	expressed	express	VERB
admet-280	153	23	afp	afp	NOUN
admet-280	153	24	at	at	ADP
admet-280	153	25	levels	level	NOUN
admet-280	153	26	comparable	comparable	ADJ
admet-280	153	27	to	to	ADP
admet-280	153	28	fetal	fetal	ADJ
admet-280	153	29	liver	liver	NOUN
admet-280	153	30	tissue	tissue	NOUN
admet-280	153	31	.	.	PUNCT
admet-280	154	1	as	as	SCONJ
admet-280	154	2	expected	expect	VERB
admet-280	154	3	,	,	PUNCT
admet-280	154	4	afp	afp	NOUN
admet-280	154	5	expression	expression	NOUN
admet-280	154	6	admet	admet	PROPN
admet-280	154	7	&	&	CCONJ
admet-280	154	8	dmpk	dmpk	PROPN
admet-280	154	9	4(2	4(2	NUM
admet-280	154	10	)	)	PUNCT
admet-280	154	11	(	(	PUNCT
admet-280	154	12	2016	2016	NUM
admet-280	154	13	)	)	PUNCT
admet-280	154	14	62	62	NUM
admet-280	154	15	-	-	SYM
admet-280	154	16	83	83	NUM
admet-280	154	17	pharmacogenetics	pharmacogenetic	NOUN
admet-280	154	18	and	and	CCONJ
admet-280	154	19	cyp	cyp	ADJ
admet-280	154	20	activity	activity	NOUN
admet-280	154	21	doi	doi	NOUN
admet-280	154	22	:	:	PUNCT
admet-280	154	23	10.5599	10.5599	NUM
admet-280	154	24	/	/	SYM
admet-280	154	25	admet.4.2.280	admet.4.2.280	NUM
admet-280	154	26	69	69	NUM
admet-280	154	27	figure	figure	NOUN
admet-280	154	28	2	2	NUM
admet-280	154	29	.	.	PUNCT
admet-280	154	30	scdh	scdh	VERB
admet-280	154	31	gene	gene	NOUN
admet-280	154	32	exp	exp	NOUN
admet-280	154	33	.	.	PUNCT
admet-280	155	1	characterization	characterization	NOUN
admet-280	155	2	.	.	PUNCT
admet-280	156	1	qrt	qrt	ADJ
admet-280	156	2	-	-	PUNCT
admet-280	156	3	pcr	pcr	ADJ
admet-280	156	4	results	result	NOUN
admet-280	156	5	shown	show	VERB
admet-280	156	6	as	as	ADP
admet-280	156	7	fold	fold	ADJ
admet-280	156	8	change	change	NOUN
admet-280	156	9	compared	compare	VERB
admet-280	156	10	to	to	ADP
admet-280	156	11	differentiated	differentiated	ADJ
admet-280	156	12	heparg	heparg	NOUN
admet-280	156	13	cells	cell	NOUN
admet-280	156	14	,	,	PUNCT
admet-280	156	15	which	which	PRON
admet-280	156	16	was	be	AUX
admet-280	156	17	set	set	VERB
admet-280	156	18	to	to	ADP
admet-280	156	19	1	1	NUM
admet-280	156	20	.	.	PUNCT
admet-280	157	1	gus	gus	NOUN
admet-280	157	2	-	-	PUNCT
admet-280	157	3	b	b	PROPN
admet-280	157	4	was	be	AUX
admet-280	157	5	used	use	VERB
admet-280	157	6	as	as	ADP
admet-280	157	7	a	a	DET
admet-280	157	8	housekeeping	housekeeping	NOUN
admet-280	157	9	gene	gene	NOUN
admet-280	157	10	.	.	PUNCT
admet-280	158	1	for	for	ADP
admet-280	158	2	all	all	DET
admet-280	158	3	stem	stem	NOUN
admet-280	158	4	cell	cell	NOUN
admet-280	158	5	and	and	CCONJ
admet-280	158	6	scdh	scdh	VERB
admet-280	158	7	samples	sample	NOUN
admet-280	158	8	,	,	PUNCT
admet-280	158	9	error	error	NOUN
admet-280	158	10	bars	bar	NOUN
admet-280	158	11	represent	represent	VERB
admet-280	158	12	a	a	DET
admet-280	158	13	pool	pool	NOUN
admet-280	158	14	of	of	ADP
admet-280	158	15	triplicate	triplicate	VERB
admet-280	158	16	biological	biological	ADJ
admet-280	158	17	replicates	replicate	NOUN
admet-280	158	18	and	and	CCONJ
admet-280	158	19	triplicate	triplicate	VERB
admet-280	158	20	technical	technical	ADJ
admet-280	158	21	replicates	replicate	NOUN
admet-280	158	22	.	.	PUNCT
admet-280	159	1	for	for	ADP
admet-280	159	2	all	all	DET
admet-280	159	3	other	other	ADJ
admet-280	159	4	samples	sample	NOUN
admet-280	159	5	,	,	PUNCT
admet-280	159	6	error	error	NOUN
admet-280	159	7	bars	bar	NOUN
admet-280	159	8	represent	represent	VERB
admet-280	159	9	triplicate	triplicate	VERB
admet-280	159	10	technical	technical	ADJ
admet-280	159	11	replicates	replicate	NOUN
admet-280	159	12	.	.	PUNCT
admet-280	160	1	heparg	heparg	PROPN
admet-280	160	2	undiff	undiff	PROPN
admet-280	160	3	represents	represent	VERB
admet-280	160	4	undifferentiated	undifferentiated	ADJ
admet-280	160	5	heparg	heparg	NOUN
admet-280	160	6	cells	cell	NOUN
admet-280	160	7	;	;	PUNCT
admet-280	160	8	heparg	heparg	NOUN
admet-280	160	9	diff	diff	NOUN
admet-280	160	10	represents	represent	VERB
admet-280	160	11	differentiated	differentiated	ADJ
admet-280	160	12	heparg	heparg	NOUN
admet-280	160	13	cells	cell	NOUN
admet-280	160	14	;	;	PUNCT
admet-280	160	15	fl1	fl1	ADV
admet-280	160	16	,	,	PUNCT
admet-280	160	17	fl2	fl2	PROPN
admet-280	160	18	,	,	PUNCT
admet-280	160	19	fl3	fl3	VERB
admet-280	160	20	,	,	PUNCT
admet-280	160	21	fl4	fl4	PROPN
admet-280	160	22	,	,	PUNCT
admet-280	160	23	fl5	fl5	PROPN
admet-280	160	24	,	,	PUNCT
admet-280	160	25	fl6	fl6	PROPN
admet-280	160	26	represent	represent	VERB
admet-280	160	27	fetal	fetal	ADJ
admet-280	160	28	liver	liver	NOUN
admet-280	160	29	tissue	tissue	NOUN
admet-280	160	30	1	1	NUM
admet-280	160	31	,	,	PUNCT
admet-280	160	32	2	2	NUM
admet-280	160	33	,	,	PUNCT
admet-280	160	34	3	3	NUM
admet-280	160	35	,	,	PUNCT
admet-280	160	36	4	4	NUM
admet-280	160	37	,	,	PUNCT
admet-280	160	38	5	5	NUM
admet-280	160	39	,	,	PUNCT
admet-280	160	40	6	6	NUM
admet-280	160	41	,	,	PUNCT
admet-280	160	42	respectively	respectively	ADV
admet-280	160	43	;	;	PUNCT
admet-280	160	44	hl161	hl161	ADJ
admet-280	160	45	and	and	CCONJ
admet-280	160	46	hl167	hl167	PROPN
admet-280	160	47	represent	represent	VERB
admet-280	160	48	human	human	ADJ
admet-280	160	49	liver	liver	NOUN
admet-280	160	50	bank	bank	NOUN
admet-280	160	51	samples	sample	NOUN
admet-280	160	52	161	161	NUM
admet-280	160	53	and	and	CCONJ
admet-280	160	54	167	167	NUM
admet-280	160	55	,	,	PUNCT
admet-280	160	56	respectively	respectively	ADV
admet-280	160	57	.	.	PUNCT
admet-280	161	1	voellinger	voellinger	VERB
admet-280	161	2	and	and	CCONJ
admet-280	161	3	kelly	kelly	PROPN
admet-280	161	4	admet	admet	PROPN
admet-280	161	5	&	&	CCONJ
admet-280	161	6	dmpk	dmpk	PROPN
admet-280	161	7	4(2	4(2	NUM
admet-280	161	8	)	)	PUNCT
admet-280	161	9	(	(	PUNCT
admet-280	161	10	2016	2016	NUM
admet-280	161	11	)	)	PUNCT
admet-280	161	12	62	62	NUM
admet-280	161	13	-	-	SYM
admet-280	161	14	83	83	NUM
admet-280	161	15	70	70	NUM
admet-280	161	16	was	be	AUX
admet-280	161	17	minimally	minimally	ADV
admet-280	161	18	expressed	express	VERB
admet-280	161	19	in	in	ADP
admet-280	161	20	adult	adult	NOUN
admet-280	161	21	liver	liver	NOUN
admet-280	161	22	tissues	tissue	NOUN
admet-280	161	23	.	.	PUNCT
admet-280	162	1	the	the	DET
admet-280	162	2	persistent	persistent	ADJ
admet-280	162	3	expression	expression	NOUN
admet-280	162	4	of	of	ADP
admet-280	162	5	afp	afp	PROPN
admet-280	162	6	in	in	ADP
admet-280	162	7	scdhs	scdhs	PROPN
admet-280	162	8	is	be	AUX
admet-280	162	9	in	in	ADP
admet-280	162	10	accordance	accordance	NOUN
admet-280	162	11	with	with	ADP
admet-280	162	12	published	publish	VERB
admet-280	162	13	reports	report	NOUN
admet-280	162	14	indicating	indicate	VERB
admet-280	162	15	a	a	DET
admet-280	162	16	high	high	ADJ
admet-280	162	17	retention	retention	NOUN
admet-280	162	18	of	of	ADP
admet-280	162	19	afp	afp	NOUN
admet-280	162	20	expression	expression	NOUN
admet-280	162	21	in	in	ADP
admet-280	162	22	scdhs	scdhs	PROPN
admet-280	162	23	.	.	PUNCT
admet-280	163	1	overall	overall	ADV
admet-280	163	2	,	,	PUNCT
admet-280	163	3	scdhs	scdhs	PROPN
admet-280	163	4	appear	appear	VERB
admet-280	163	5	to	to	PART
admet-280	163	6	express	express	VERB
admet-280	163	7	the	the	DET
admet-280	163	8	hepatocyte	hepatocyte	NOUN
admet-280	163	9	markers	marker	NOUN
admet-280	163	10	afp	afp	PROPN
admet-280	163	11	,	,	PUNCT
admet-280	163	12	alb	alb	PROPN
admet-280	163	13	,	,	PUNCT
admet-280	163	14	and	and	CCONJ
admet-280	163	15	hnf4α	hnf4α	PROPN
admet-280	164	1	at	at	ADP
admet-280	164	2	levels	level	NOUN
admet-280	164	3	comparable	comparable	ADJ
admet-280	164	4	to	to	ADP
admet-280	164	5	fetal	fetal	ADJ
admet-280	164	6	liver	liver	NOUN
admet-280	164	7	tissue	tissue	NOUN
admet-280	164	8	,	,	PUNCT
admet-280	164	9	indicating	indicate	VERB
admet-280	164	10	a	a	DET
admet-280	164	11	close	close	ADJ
admet-280	164	12	resemblance	resemblance	NOUN
admet-280	164	13	to	to	ADP
admet-280	164	14	a	a	DET
admet-280	164	15	fetal	fetal	ADJ
admet-280	164	16	state	state	NOUN
admet-280	164	17	hepatocyte	hepatocyte	NOUN
admet-280	164	18	.	.	PUNCT
admet-280	165	1	transcription	transcription	NOUN
admet-280	165	2	factors	factor	NOUN
admet-280	165	3	which	which	PRON
admet-280	165	4	regulate	regulate	VERB
admet-280	165	5	drug	drug	NOUN
admet-280	165	6	metabolizing	metabolize	VERB
admet-280	165	7	enzymes	enzyme	NOUN
admet-280	165	8	and	and	CCONJ
admet-280	165	9	transporters	transporter	NOUN
admet-280	165	10	were	be	AUX
admet-280	165	11	evaluated	evaluate	VERB
admet-280	165	12	.	.	PUNCT
admet-280	166	1	the	the	DET
admet-280	166	2	transcription	transcription	NOUN
admet-280	166	3	factors	factor	VERB
admet-280	166	4	constitutive	constitutive	ADJ
admet-280	166	5	androstane	androstane	ADJ
admet-280	166	6	receptor	receptor	NOUN
admet-280	166	7	(	(	PUNCT
admet-280	166	8	car	car	NOUN
admet-280	166	9	)	)	PUNCT
admet-280	166	10	,	,	PUNCT
admet-280	166	11	pregnane	pregnane	NOUN
admet-280	166	12	x	x	SYM
admet-280	166	13	receptor	receptor	NOUN
admet-280	166	14	(	(	PUNCT
admet-280	166	15	pxr	pxr	PROPN
admet-280	166	16	)	)	PUNCT
admet-280	166	17	and	and	CCONJ
admet-280	166	18	aryl	aryl	NOUN
admet-280	166	19	hydrocarbon	hydrocarbon	NOUN
admet-280	166	20	receptor	receptor	NOUN
admet-280	166	21	(	(	PUNCT
admet-280	166	22	ahr	ahr	PROPN
admet-280	166	23	)	)	PUNCT
admet-280	166	24	were	be	AUX
admet-280	166	25	selected	select	VERB
admet-280	166	26	because	because	SCONJ
admet-280	166	27	they	they	PRON
admet-280	166	28	regulate	regulate	VERB
admet-280	166	29	many	many	ADJ
admet-280	166	30	of	of	ADP
admet-280	166	31	the	the	DET
admet-280	166	32	hepatic	hepatic	ADJ
admet-280	166	33	phase	phase	NOUN
admet-280	166	34	i	i	PRON
admet-280	166	35	and	and	CCONJ
admet-280	166	36	ii	ii	NOUN
admet-280	166	37	drugmetabolizing	drugmetabolizing	NOUN
admet-280	166	38	enzymes	enzyme	NOUN
admet-280	166	39	and	and	CCONJ
admet-280	166	40	transporters	transporter	NOUN
admet-280	166	41	[	[	X
admet-280	166	42	40	40	NUM
admet-280	166	43	,	,	PUNCT
admet-280	166	44	41	41	NUM
admet-280	166	45	]	]	PUNCT
admet-280	166	46	.	.	PUNCT
admet-280	167	1	the	the	DET
admet-280	167	2	expression	expression	NOUN
admet-280	167	3	of	of	ADP
admet-280	167	4	car	car	NOUN
admet-280	167	5	,	,	PUNCT
admet-280	167	6	pxr	pxr	NOUN
admet-280	167	7	and	and	CCONJ
admet-280	167	8	ahr	ahr	PROPN
admet-280	167	9	in	in	ADP
admet-280	167	10	scdhs	scdhs	PROPN
admet-280	167	11	was	be	AUX
admet-280	167	12	minimal	minimal	ADJ
admet-280	167	13	(	(	PUNCT
admet-280	167	14	supplemental	supplemental	ADJ
admet-280	167	15	figure	figure	NOUN
admet-280	167	16	1	1	NUM
admet-280	167	17	)	)	PUNCT
admet-280	167	18	.	.	PUNCT
admet-280	168	1	the	the	DET
admet-280	168	2	expression	expression	NOUN
admet-280	168	3	of	of	ADP
admet-280	168	4	ahr	ahr	PROPN
admet-280	168	5	in	in	ADP
admet-280	168	6	scdhs	scdhs	PROPN
admet-280	168	7	was	be	AUX
admet-280	168	8	comparable	comparable	ADJ
admet-280	168	9	to	to	ADP
admet-280	168	10	that	that	PRON
admet-280	168	11	in	in	ADP
admet-280	168	12	fetal	fetal	ADJ
admet-280	168	13	liver	liver	NOUN
admet-280	168	14	tissues	tissue	NOUN
admet-280	168	15	,	,	PUNCT
admet-280	168	16	while	while	SCONJ
admet-280	168	17	the	the	DET
admet-280	168	18	expression	expression	NOUN
admet-280	168	19	of	of	ADP
admet-280	168	20	car	car	NOUN
admet-280	168	21	and	and	CCONJ
admet-280	168	22	pxr	pxr	NOUN
admet-280	168	23	in	in	ADP
admet-280	168	24	scdhs	scdhs	NOUN
admet-280	168	25	was	be	AUX
admet-280	168	26	lower	low	ADJ
admet-280	168	27	than	than	ADP
admet-280	168	28	that	that	PRON
admet-280	168	29	in	in	ADP
admet-280	168	30	fetal	fetal	ADJ
admet-280	168	31	liver	liver	NOUN
admet-280	168	32	tissues	tissue	NOUN
admet-280	168	33	.	.	PUNCT
admet-280	169	1	the	the	DET
admet-280	169	2	expression	expression	NOUN
admet-280	169	3	of	of	ADP
admet-280	169	4	cyps	cyps	PROPN
admet-280	169	5	and	and	CCONJ
admet-280	169	6	flavin	flavin	NOUN
admet-280	169	7	containing	contain	VERB
admet-280	169	8	monooxygenases	monooxygenase	NOUN
admet-280	169	9	(	(	PUNCT
admet-280	169	10	fmo	fmo	NOUN
admet-280	169	11	)	)	PUNCT
admet-280	169	12	were	be	AUX
admet-280	169	13	evaluated	evaluate	VERB
admet-280	169	14	.	.	PUNCT
admet-280	170	1	with	with	ADP
admet-280	170	2	regard	regard	NOUN
admet-280	170	3	to	to	ADP
admet-280	170	4	fmos	fmos	PROPN
admet-280	170	5	,	,	PUNCT
admet-280	170	6	fmo1	fmo1	PROPN
admet-280	170	7	is	be	AUX
admet-280	170	8	normally	normally	ADV
admet-280	170	9	expressed	express	VERB
admet-280	170	10	to	to	ADP
admet-280	170	11	a	a	DET
admet-280	170	12	greater	great	ADJ
admet-280	170	13	extent	extent	NOUN
admet-280	170	14	in	in	ADP
admet-280	170	15	the	the	DET
admet-280	170	16	fetal	fetal	ADJ
admet-280	170	17	liver	liver	NOUN
admet-280	170	18	,	,	PUNCT
admet-280	170	19	and	and	CCONJ
admet-280	170	20	so	so	ADV
admet-280	170	21	can	can	AUX
admet-280	170	22	be	be	AUX
admet-280	170	23	used	use	VERB
admet-280	170	24	as	as	ADP
admet-280	170	25	another	another	DET
admet-280	170	26	marker	marker	NOUN
admet-280	170	27	to	to	PART
admet-280	170	28	evaluate	evaluate	VERB
admet-280	170	29	how	how	SCONJ
admet-280	170	30	fetal	fetal	ADJ
admet-280	170	31	-	-	PUNCT
admet-280	170	32	like	like	ADJ
admet-280	170	33	scdhs	scdhs	NOUN
admet-280	170	34	are	be	AUX
admet-280	170	35	.	.	PUNCT
admet-280	171	1	indeed	indeed	ADV
admet-280	171	2	,	,	PUNCT
admet-280	171	3	from	from	ADP
admet-280	171	4	gene	gene	NOUN
admet-280	171	5	expression	expression	NOUN
admet-280	171	6	profiling	profiling	NOUN
admet-280	171	7	fmo1	fmo1	NOUN
admet-280	171	8	was	be	AUX
admet-280	171	9	highly	highly	ADV
admet-280	171	10	expressed	express	VERB
admet-280	171	11	in	in	ADP
admet-280	171	12	fetal	fetal	ADJ
admet-280	171	13	liver	liver	NOUN
admet-280	171	14	tissue	tissue	NOUN
admet-280	171	15	,	,	PUNCT
admet-280	171	16	at	at	ADP
admet-280	171	17	levels	level	NOUN
admet-280	171	18	20to	20to	NOUN
admet-280	171	19	50	50	NUM
admet-280	171	20	-	-	NOUN
admet-280	171	21	fold	fold	VERB
admet-280	171	22	higher	high	ADJ
admet-280	171	23	than	than	ADP
admet-280	171	24	that	that	PRON
admet-280	171	25	in	in	ADP
admet-280	171	26	differentiated	differentiated	ADJ
admet-280	171	27	heparg	heparg	NOUN
admet-280	171	28	cells	cell	NOUN
admet-280	171	29	,	,	PUNCT
admet-280	171	30	while	while	SCONJ
admet-280	171	31	fmo1	fmo1	NOUN
admet-280	171	32	expression	expression	NOUN
admet-280	171	33	was	be	AUX
admet-280	171	34	undetected	undetecte	VERB
admet-280	171	35	in	in	ADP
admet-280	171	36	adult	adult	NOUN
admet-280	171	37	liver	liver	NOUN
admet-280	171	38	tissues	tissue	NOUN
admet-280	171	39	(	(	PUNCT
admet-280	171	40	figure	figure	NOUN
admet-280	171	41	2	2	NUM
admet-280	171	42	)	)	PUNCT
admet-280	171	43	.	.	PUNCT
admet-280	172	1	fmo1	fmo1	NOUN
admet-280	172	2	expression	expression	NOUN
admet-280	172	3	in	in	ADP
admet-280	172	4	scdhs	scdhs	PROPN
admet-280	172	5	increased	increase	VERB
admet-280	172	6	through	through	ADP
admet-280	172	7	differentiation	differentiation	NOUN
admet-280	172	8	,	,	PUNCT
admet-280	172	9	up	up	ADP
admet-280	172	10	to	to	ADP
admet-280	172	11	7to	7to	NOUN
admet-280	172	12	13fold	13fold	NUM
admet-280	172	13	higher	high	ADJ
admet-280	172	14	than	than	ADP
admet-280	172	15	differentiated	differentiated	ADJ
admet-280	172	16	heparg	heparg	NOUN
admet-280	172	17	cells	cell	NOUN
admet-280	172	18	(	(	PUNCT
admet-280	172	19	figure	figure	NOUN
admet-280	172	20	2	2	NUM
admet-280	172	21	)	)	PUNCT
admet-280	172	22	.	.	PUNCT
admet-280	173	1	while	while	SCONJ
admet-280	173	2	scdhs	scdhs	ADJ
admet-280	173	3	retain	retain	VERB
admet-280	173	4	high	high	ADJ
admet-280	173	5	expression	expression	NOUN
admet-280	173	6	of	of	ADP
admet-280	173	7	fmo1	fmo1	PROPN
admet-280	173	8	,	,	PUNCT
admet-280	173	9	it	it	PRON
admet-280	173	10	was	be	AUX
admet-280	173	11	lower	low	ADJ
admet-280	173	12	than	than	ADP
admet-280	173	13	that	that	PRON
admet-280	173	14	in	in	ADP
admet-280	173	15	fetal	fetal	ADJ
admet-280	173	16	liver	liver	NOUN
admet-280	173	17	tissue	tissue	NOUN
admet-280	173	18	.	.	PUNCT
admet-280	174	1	the	the	DET
admet-280	174	2	cyp	cyp	ADJ
admet-280	174	3	enzymes	enzyme	NOUN
admet-280	174	4	cyp3a4	cyp3a4	NOUN
admet-280	174	5	and	and	CCONJ
admet-280	174	6	cyp3a7	cyp3a7	NOUN
admet-280	174	7	also	also	ADV
admet-280	174	8	exhibit	exhibit	VERB
admet-280	174	9	differential	differential	ADJ
admet-280	174	10	expression	expression	NOUN
admet-280	174	11	between	between	ADP
admet-280	174	12	fetal	fetal	ADJ
admet-280	174	13	and	and	CCONJ
admet-280	174	14	adult	adult	NOUN
admet-280	174	15	liver	liver	NOUN
admet-280	174	16	,	,	PUNCT
admet-280	174	17	with	with	ADP
admet-280	174	18	cyp3a7	cyp3a7	PROPN
admet-280	174	19	being	be	AUX
admet-280	174	20	the	the	DET
admet-280	174	21	predominant	predominant	ADJ
admet-280	174	22	isoform	isoform	NOUN
admet-280	174	23	in	in	ADP
admet-280	174	24	fetal	fetal	ADJ
admet-280	174	25	liver	liver	NOUN
admet-280	174	26	and	and	CCONJ
admet-280	174	27	cyp3a4	cyp3a4	NOUN
admet-280	174	28	being	be	AUX
admet-280	174	29	predominant	predominant	ADJ
admet-280	174	30	in	in	ADP
admet-280	174	31	the	the	DET
admet-280	174	32	adult	adult	NOUN
admet-280	174	33	liver	liver	NOUN
admet-280	174	34	.	.	PUNCT
admet-280	175	1	this	this	DET
admet-280	175	2	pattern	pattern	NOUN
admet-280	175	3	was	be	AUX
admet-280	175	4	also	also	ADV
admet-280	175	5	observed	observe	VERB
admet-280	175	6	between	between	ADP
admet-280	175	7	our	our	PRON
admet-280	175	8	fetal	fetal	ADJ
admet-280	175	9	and	and	CCONJ
admet-280	175	10	adult	adult	NOUN
admet-280	175	11	liver	liver	NOUN
admet-280	175	12	tissue	tissue	NOUN
admet-280	175	13	samples	sample	NOUN
admet-280	175	14	.	.	PUNCT
admet-280	176	1	cyp3a4	cyp3a4	PROPN
admet-280	176	2	was	be	AUX
admet-280	176	3	detected	detect	VERB
admet-280	176	4	in	in	ADP
admet-280	176	5	only	only	ADV
admet-280	176	6	one	one	NUM
admet-280	176	7	scdh	scdh	NOUN
admet-280	176	8	sample	sample	NOUN
admet-280	176	9	,	,	PUNCT
admet-280	176	10	with	with	ADP
admet-280	176	11	expression	expression	NOUN
admet-280	176	12	well	well	ADV
admet-280	176	13	below	below	ADV
admet-280	176	14	(	(	PUNCT
admet-280	176	15	0.0003	0.0003	NUM
admet-280	176	16	-	-	ADJ
admet-280	176	17	fold	fold	ADJ
admet-280	176	18	)	)	PUNCT
admet-280	176	19	that	that	PRON
admet-280	176	20	observed	observe	VERB
admet-280	176	21	in	in	ADP
admet-280	176	22	heparg	heparg	NOUN
admet-280	176	23	cells	cell	NOUN
admet-280	176	24	(	(	PUNCT
admet-280	176	25	figure	figure	NOUN
admet-280	176	26	2	2	NUM
admet-280	176	27	)	)	PUNCT
admet-280	176	28	.	.	PUNCT
admet-280	177	1	cyp3a7	cyp3a7	PROPN
admet-280	177	2	was	be	AUX
admet-280	177	3	detected	detect	VERB
admet-280	177	4	in	in	ADP
admet-280	177	5	two	two	NUM
admet-280	177	6	scdh	scdh	NOUN
admet-280	177	7	samples	sample	NOUN
admet-280	177	8	,	,	PUNCT
admet-280	177	9	at	at	ADP
admet-280	177	10	4.5and	4.5and	NUM
admet-280	177	11	11.8	11.8	NUM
admet-280	177	12	-	-	NOUN
admet-280	177	13	fold	fold	VERB
admet-280	177	14	higher	high	ADJ
admet-280	177	15	than	than	ADP
admet-280	177	16	heparg	heparg	NOUN
admet-280	177	17	cells	cell	NOUN
admet-280	177	18	.	.	PUNCT
admet-280	178	1	additionally	additionally	ADV
admet-280	178	2	,	,	PUNCT
admet-280	178	3	cyp3a7	cyp3a7	NOUN
admet-280	178	4	expression	expression	NOUN
admet-280	178	5	in	in	ADP
admet-280	178	6	scdhs	scdhs	PROPN
admet-280	178	7	was	be	AUX
admet-280	178	8	below	below	ADP
admet-280	178	9	expression	expression	NOUN
admet-280	178	10	levels	level	NOUN
admet-280	178	11	in	in	ADP
admet-280	178	12	fetal	fetal	ADJ
admet-280	178	13	liver	liver	NOUN
admet-280	178	14	tissue	tissue	NOUN
admet-280	178	15	(	(	PUNCT
admet-280	178	16	figure	figure	NOUN
admet-280	178	17	2	2	NUM
admet-280	178	18	)	)	PUNCT
admet-280	178	19	.	.	PUNCT
admet-280	179	1	from	from	ADP
admet-280	179	2	these	these	DET
admet-280	179	3	data	datum	NOUN
admet-280	179	4	,	,	PUNCT
admet-280	179	5	scdhs	scdhs	ADJ
admet-280	179	6	retain	retain	VERB
admet-280	179	7	expression	expression	NOUN
admet-280	179	8	of	of	ADP
admet-280	179	9	cyp3a7	cyp3a7	NOUN
admet-280	179	10	,	,	PUNCT
admet-280	179	11	though	though	SCONJ
admet-280	179	12	cyp3a7	cyp3a7	NOUN
admet-280	179	13	expression	expression	NOUN
admet-280	179	14	was	be	AUX
admet-280	179	15	lower	low	ADJ
admet-280	179	16	than	than	ADP
admet-280	179	17	fetal	fetal	ADJ
admet-280	179	18	liver	liver	NOUN
admet-280	179	19	tissue	tissue	NOUN
admet-280	179	20	,	,	PUNCT
admet-280	179	21	indicating	indicate	VERB
admet-280	179	22	an	an	DET
admet-280	179	23	overall	overall	ADJ
admet-280	179	24	lack	lack	NOUN
admet-280	179	25	of	of	ADP
admet-280	179	26	cyp3a	cyp3a	NOUN
admet-280	179	27	expression	expression	NOUN
admet-280	179	28	in	in	ADP
admet-280	179	29	scdhs	scdhs	ADJ
admet-280	179	30	.	.	PUNCT
admet-280	180	1	cyp	cyp	ADJ
admet-280	180	2	1a2	1a2	NUM
admet-280	180	3	,	,	PUNCT
admet-280	180	4	2c19	2c19	NOUN
admet-280	180	5	and	and	CCONJ
admet-280	180	6	2d6	2d6	NUM
admet-280	180	7	were	be	AUX
admet-280	180	8	undetectable	undetectable	ADJ
admet-280	180	9	in	in	ADP
admet-280	180	10	scdhs	scdhs	PROPN
admet-280	180	11	(	(	PUNCT
admet-280	180	12	supplemental	supplemental	ADJ
admet-280	180	13	figure	figure	NOUN
admet-280	180	14	1	1	NUM
admet-280	180	15	)	)	PUNCT
admet-280	180	16	.	.	PUNCT
admet-280	181	1	cyp2a6	cyp2a6	PROPN
admet-280	181	2	was	be	AUX
admet-280	181	3	expressed	express	VERB
admet-280	181	4	in	in	ADP
admet-280	181	5	scdhs	scdhs	NOUN
admet-280	181	6	,	,	PUNCT
admet-280	181	7	at	at	ADP
admet-280	181	8	levels	level	NOUN
admet-280	181	9	slightly	slightly	ADV
admet-280	181	10	above	above	ADP
admet-280	181	11	adult	adult	NOUN
admet-280	181	12	liver	liver	NOUN
admet-280	181	13	tissue	tissue	NOUN
admet-280	181	14	,	,	PUNCT
admet-280	181	15	though	though	SCONJ
admet-280	181	16	below	below	ADP
admet-280	181	17	those	those	PRON
admet-280	181	18	observed	observe	VERB
admet-280	181	19	in	in	ADP
admet-280	181	20	fetal	fetal	ADJ
admet-280	181	21	liver	liver	NOUN
admet-280	181	22	tissue	tissue	NOUN
admet-280	181	23	(	(	PUNCT
admet-280	181	24	supplemental	supplemental	ADJ
admet-280	181	25	figure	figure	NOUN
admet-280	181	26	1	1	NUM
admet-280	181	27	)	)	PUNCT
admet-280	181	28	.	.	PUNCT
admet-280	182	1	cyp2b6	cyp2b6	NOUN
admet-280	182	2	was	be	AUX
admet-280	182	3	undetectable	undetectable	ADJ
admet-280	182	4	in	in	ADP
admet-280	182	5	fetal	fetal	ADJ
admet-280	182	6	liver	liver	NOUN
admet-280	182	7	tissue	tissue	NOUN
admet-280	182	8	samples	sample	NOUN
admet-280	182	9	,	,	PUNCT
admet-280	182	10	but	but	CCONJ
admet-280	182	11	was	be	AUX
admet-280	182	12	expressed	express	VERB
admet-280	182	13	in	in	ADP
admet-280	182	14	scdhs	scdhs	ADJ
admet-280	182	15	,	,	PUNCT
admet-280	182	16	though	though	SCONJ
admet-280	182	17	at	at	ADP
admet-280	182	18	levels	level	NOUN
admet-280	182	19	below	below	ADP
admet-280	182	20	adult	adult	NOUN
admet-280	182	21	liver	liver	NOUN
admet-280	182	22	tissue	tissue	NOUN
admet-280	182	23	(	(	PUNCT
admet-280	182	24	supplemental	supplemental	ADJ
admet-280	182	25	figure	figure	NOUN
admet-280	182	26	1	1	NUM
admet-280	182	27	)	)	PUNCT
admet-280	182	28	.	.	PUNCT
admet-280	183	1	cyp	cyp	ADJ
admet-280	183	2	2c8	2c8	NUM
admet-280	183	3	,	,	PUNCT
admet-280	183	4	2c9	2c9	NUM
admet-280	183	5	and	and	CCONJ
admet-280	183	6	2e1	2e1	NUM
admet-280	183	7	were	be	AUX
admet-280	183	8	detectable	detectable	ADJ
admet-280	183	9	in	in	ADP
admet-280	183	10	scdhs	scdhs	NOUN
admet-280	183	11	,	,	PUNCT
admet-280	183	12	but	but	CCONJ
admet-280	183	13	at	at	ADP
admet-280	183	14	levels	level	NOUN
admet-280	183	15	much	much	ADV
admet-280	183	16	lower	low	ADJ
admet-280	183	17	than	than	ADP
admet-280	183	18	expression	expression	NOUN
admet-280	183	19	in	in	ADP
admet-280	183	20	adult	adult	NOUN
admet-280	183	21	liver	liver	NOUN
admet-280	183	22	tissue	tissue	NOUN
admet-280	183	23	,	,	PUNCT
admet-280	183	24	though	though	SCONJ
admet-280	183	25	comparable	comparable	ADJ
admet-280	183	26	to	to	ADP
admet-280	183	27	expression	expression	NOUN
admet-280	183	28	in	in	ADP
admet-280	183	29	fetal	fetal	ADJ
admet-280	183	30	liver	liver	NOUN
admet-280	183	31	tissue	tissue	NOUN
admet-280	183	32	(	(	PUNCT
admet-280	183	33	supplemental	supplemental	ADJ
admet-280	183	34	figure	figure	NOUN
admet-280	183	35	1	1	NUM
admet-280	183	36	)	)	PUNCT
admet-280	183	37	.	.	PUNCT
admet-280	184	1	overall	overall	ADV
admet-280	184	2	,	,	PUNCT
admet-280	184	3	there	there	PRON
admet-280	184	4	was	be	VERB
admet-280	184	5	minimal	minimal	ADJ
admet-280	184	6	expression	expression	NOUN
admet-280	184	7	of	of	ADP
admet-280	184	8	the	the	DET
admet-280	184	9	hepatic	hepatic	ADJ
admet-280	184	10	cyp	cyp	ADJ
admet-280	184	11	enzymes	enzyme	NOUN
admet-280	184	12	in	in	ADP
admet-280	184	13	scdhs	scdhs	NOUN
admet-280	184	14	,	,	PUNCT
admet-280	184	15	with	with	ADP
admet-280	184	16	the	the	DET
admet-280	184	17	exception	exception	NOUN
admet-280	184	18	of	of	ADP
admet-280	184	19	the	the	DET
admet-280	184	20	fetal	fetal	ADJ
admet-280	184	21	cyp3a7	cyp3a7	NOUN
admet-280	184	22	enzyme	enzyme	NOUN
admet-280	184	23	.	.	PUNCT
admet-280	185	1	the	the	DET
admet-280	185	2	low	low	ADJ
admet-280	185	3	expression	expression	NOUN
admet-280	185	4	of	of	ADP
admet-280	185	5	cyp	cyp	ADJ
admet-280	185	6	enzymes	enzyme	NOUN
admet-280	185	7	in	in	ADP
admet-280	185	8	scdhs	scdhs	PROPN
admet-280	185	9	would	would	AUX
admet-280	185	10	result	result	VERB
admet-280	185	11	in	in	ADP
admet-280	185	12	low	low	ADJ
admet-280	185	13	functional	functional	ADJ
admet-280	185	14	activity	activity	NOUN
admet-280	185	15	and	and	CCONJ
admet-280	185	16	was	be	AUX
admet-280	185	17	unexpected	unexpected	ADJ
admet-280	185	18	given	give	VERB
admet-280	185	19	that	that	SCONJ
admet-280	185	20	hnf4α	hnf4α	PROPN
admet-280	185	21	was	be	AUX
admet-280	185	22	expressed	express	VERB
admet-280	185	23	at	at	ADP
admet-280	185	24	a	a	DET
admet-280	185	25	level	level	NOUN
admet-280	185	26	consistent	consistent	ADJ
admet-280	185	27	with	with	ADP
admet-280	185	28	fetal	fetal	ADJ
admet-280	185	29	and	and	CCONJ
admet-280	185	30	adult	adult	NOUN
admet-280	185	31	liver	liver	NOUN
admet-280	185	32	tissue	tissue	NOUN
admet-280	185	33	.	.	PUNCT
admet-280	186	1	hnf4α	hnf4α	PROPN
admet-280	186	2	is	be	AUX
admet-280	186	3	known	know	VERB
admet-280	186	4	to	to	PART
admet-280	186	5	have	have	VERB
admet-280	186	6	a	a	DET
admet-280	186	7	role	role	NOUN
admet-280	186	8	in	in	ADP
admet-280	186	9	supporting	support	VERB
admet-280	186	10	the	the	DET
admet-280	186	11	constitutive	constitutive	ADJ
admet-280	186	12	expression	expression	NOUN
admet-280	186	13	of	of	ADP
admet-280	186	14	cyp	cyp	ADJ
admet-280	186	15	enzymes	enzyme	NOUN
admet-280	186	16	in	in	ADP
admet-280	186	17	human	human	ADJ
admet-280	186	18	hepatocytes	hepatocyte	NOUN
admet-280	187	1	[	[	X
admet-280	187	2	42	42	NUM
admet-280	187	3	]	]	PUNCT
admet-280	187	4	.	.	PUNCT
admet-280	188	1	given	give	VERB
admet-280	188	2	the	the	DET
admet-280	188	3	relative	relative	ADJ
admet-280	188	4	expression	expression	NOUN
admet-280	188	5	of	of	ADP
admet-280	188	6	hnf4α	hnf4α	PROPN
admet-280	188	7	,	,	PUNCT
admet-280	188	8	we	we	PRON
admet-280	188	9	would	would	AUX
admet-280	188	10	expect	expect	VERB
admet-280	188	11	higher	high	ADJ
admet-280	188	12	cyp	cyp	ADJ
admet-280	188	13	expression	expression	NOUN
admet-280	188	14	in	in	ADP
admet-280	188	15	the	the	DET
admet-280	188	16	scdhs	scdhs	NOUN
admet-280	188	17	.	.	PUNCT
admet-280	189	1	the	the	DET
admet-280	189	2	expression	expression	NOUN
admet-280	189	3	of	of	ADP
admet-280	189	4	p450	p450	PROPN
admet-280	189	5	oxidoreductase	oxidoreductase	NOUN
admet-280	189	6	(	(	PUNCT
admet-280	189	7	por	por	NOUN
admet-280	189	8	)	)	PUNCT
admet-280	189	9	was	be	AUX
admet-280	189	10	also	also	ADV
admet-280	189	11	evaluated	evaluate	VERB
admet-280	189	12	.	.	PUNCT
admet-280	190	1	por	por	NOUN
admet-280	190	2	is	be	AUX
admet-280	190	3	essential	essential	ADJ
admet-280	190	4	for	for	ADP
admet-280	190	5	normal	normal	ADJ
admet-280	190	6	function	function	NOUN
admet-280	190	7	of	of	ADP
admet-280	190	8	the	the	DET
admet-280	190	9	cyp	cyp	ADJ
admet-280	190	10	enzymes	enzyme	NOUN
admet-280	190	11	it	it	PRON
admet-280	190	12	is	be	AUX
admet-280	190	13	needed	need	VERB
admet-280	190	14	for	for	ADP
admet-280	190	15	electron	electron	NOUN
admet-280	190	16	transfer	transfer	NOUN
admet-280	190	17	from	from	ADP
admet-280	190	18	nadph	nadph	ADJ
admet-280	190	19	to	to	ADP
admet-280	190	20	the	the	DET
admet-280	190	21	cyp	cyp	ADJ
admet-280	190	22	[	[	X
admet-280	190	23	43	43	NUM
admet-280	190	24	,	,	PUNCT
admet-280	190	25	44	44	NUM
admet-280	190	26	]	]	PUNCT
admet-280	190	27	.	.	PUNCT
admet-280	191	1	por	por	NOUN
admet-280	191	2	expression	expression	NOUN
admet-280	191	3	in	in	ADP
admet-280	191	4	scdhs	scdhs	PROPN
admet-280	191	5	was	be	AUX
admet-280	191	6	below	below	ADP
admet-280	191	7	that	that	PRON
admet-280	191	8	expressed	express	VERB
admet-280	191	9	in	in	ADP
admet-280	191	10	heparg	heparg	NOUN
admet-280	191	11	differentiated	differentiate	VERB
admet-280	191	12	cells	cell	NOUN
admet-280	191	13	,	,	PUNCT
admet-280	191	14	ranging	range	VERB
admet-280	191	15	from	from	ADP
admet-280	191	16	0.07to	0.07to	NOUN
admet-280	191	17	0.56	0.56	NUM
admet-280	191	18	-	-	NUM
admet-280	191	19	fold	fold	ADJ
admet-280	191	20	(	(	PUNCT
admet-280	191	21	figure	figure	NOUN
admet-280	191	22	2	2	NUM
admet-280	191	23	)	)	PUNCT
admet-280	191	24	.	.	PUNCT
admet-280	192	1	this	this	DET
admet-280	192	2	expression	expression	NOUN
admet-280	192	3	was	be	AUX
admet-280	192	4	also	also	ADV
admet-280	192	5	well	well	ADV
admet-280	192	6	below	below	ADP
admet-280	192	7	that	that	PRON
admet-280	192	8	found	find	VERB
admet-280	192	9	in	in	ADP
admet-280	192	10	fetal	fetal	ADJ
admet-280	192	11	and	and	CCONJ
admet-280	192	12	adult	adult	NOUN
admet-280	192	13	liver	liver	NOUN
admet-280	192	14	tissues	tissue	NOUN
admet-280	192	15	(	(	PUNCT
admet-280	192	16	figure	figure	NOUN
admet-280	192	17	2	2	NUM
admet-280	192	18	)	)	PUNCT
admet-280	192	19	.	.	PUNCT
admet-280	193	1	interestingly	interestingly	ADV
admet-280	193	2	,	,	PUNCT
admet-280	193	3	the	the	DET
admet-280	193	4	undifferentiated	undifferentiated	ADJ
admet-280	193	5	hesc	hesc	NOUN
admet-280	193	6	samples	sample	NOUN
admet-280	193	7	exhibited	exhibit	VERB
admet-280	193	8	higher	high	ADJ
admet-280	193	9	por	por	NOUN
admet-280	193	10	expression	expression	NOUN
admet-280	193	11	than	than	ADP
admet-280	193	12	scdhs	scdhs	VERB
admet-280	193	13	.	.	PUNCT
admet-280	194	1	a	a	DET
admet-280	194	2	potential	potential	ADJ
admet-280	194	3	reason	reason	NOUN
admet-280	194	4	for	for	ADP
admet-280	194	5	the	the	DET
admet-280	194	6	higher	high	ADJ
admet-280	194	7	expression	expression	NOUN
admet-280	194	8	of	of	ADP
admet-280	194	9	por	por	NOUN
admet-280	194	10	in	in	ADP
admet-280	194	11	stem	stem	NOUN
admet-280	194	12	cells	cell	NOUN
admet-280	194	13	could	could	AUX
admet-280	194	14	be	be	AUX
admet-280	194	15	its	its	PRON
admet-280	194	16	use	use	NOUN
admet-280	194	17	in	in	ADP
admet-280	194	18	supporting	support	VERB
admet-280	194	19	other	other	ADJ
admet-280	194	20	cyp	cyp	ADJ
admet-280	194	21	enzymes	enzyme	NOUN
admet-280	194	22	.	.	PUNCT
admet-280	195	1	for	for	ADP
admet-280	195	2	example	example	NOUN
admet-280	195	3	,	,	PUNCT
admet-280	195	4	cyp26	cyp26	NOUN
admet-280	195	5	plays	play	VERB
admet-280	195	6	an	an	DET
admet-280	195	7	important	important	ADJ
admet-280	195	8	role	role	NOUN
admet-280	195	9	in	in	ADP
admet-280	195	10	embryonic	embryonic	ADJ
admet-280	195	11	stem	stem	NOUN
admet-280	195	12	cells	cell	NOUN
admet-280	195	13	to	to	PART
admet-280	195	14	promote	promote	VERB
admet-280	195	15	cell	cell	NOUN
admet-280	195	16	differentiation	differentiation	NOUN
admet-280	195	17	through	through	ADP
admet-280	195	18	retinoid	retinoid	NOUN
admet-280	195	19	signaling	signal	VERB
admet-280	195	20	[	[	X
admet-280	195	21	45	45	NUM
admet-280	195	22	,	,	PUNCT
admet-280	195	23	46	46	NUM
admet-280	195	24	]	]	PUNCT
admet-280	195	25	.	.	PUNCT
admet-280	196	1	the	the	DET
admet-280	196	2	low	low	ADJ
admet-280	196	3	expression	expression	NOUN
admet-280	196	4	of	of	ADP
admet-280	196	5	por	por	NOUN
admet-280	196	6	in	in	ADP
admet-280	196	7	scdhs	scdhs	PROPN
admet-280	196	8	may	may	AUX
admet-280	196	9	contribute	contribute	VERB
admet-280	196	10	to	to	ADP
admet-280	196	11	the	the	DET
admet-280	196	12	observed	observe	VERB
admet-280	196	13	low	low	ADJ
admet-280	196	14	functional	functional	ADJ
admet-280	196	15	activity	activity	NOUN
admet-280	196	16	for	for	ADP
admet-280	196	17	the	the	DET
admet-280	196	18	drugmetabolizing	drugmetabolize	VERB
admet-280	196	19	cyp	cyp	ADJ
admet-280	196	20	enzymes	enzyme	NOUN
admet-280	196	21	.	.	PUNCT
admet-280	197	1	admet	admet	PROPN
admet-280	197	2	&	&	CCONJ
admet-280	197	3	dmpk	dmpk	PROPN
admet-280	197	4	4(2	4(2	NUM
admet-280	197	5	)	)	PUNCT
admet-280	197	6	(	(	PUNCT
admet-280	197	7	2016	2016	NUM
admet-280	197	8	)	)	PUNCT
admet-280	197	9	62	62	NUM
admet-280	197	10	-	-	SYM
admet-280	197	11	83	83	NUM
admet-280	197	12	pharmacogenetics	pharmacogenetic	NOUN
admet-280	197	13	and	and	CCONJ
admet-280	197	14	cyp	cyp	ADJ
admet-280	197	15	activity	activity	NOUN
admet-280	197	16	doi	doi	NOUN
admet-280	197	17	:	:	PUNCT
admet-280	197	18	10.5599	10.5599	NUM
admet-280	197	19	/	/	SYM
admet-280	197	20	admet.4.2.280	admet.4.2.280	SYM
admet-280	197	21	71	71	NUM
admet-280	197	22	to	to	PART
admet-280	197	23	examine	examine	VERB
admet-280	197	24	expression	expression	NOUN
admet-280	197	25	of	of	ADP
admet-280	197	26	phase	phase	NOUN
admet-280	197	27	ii	ii	NOUN
admet-280	197	28	drug	drug	NOUN
admet-280	197	29	-	-	PUNCT
admet-280	197	30	metabolizing	metabolize	VERB
admet-280	197	31	enzymes	enzyme	NOUN
admet-280	197	32	,	,	PUNCT
admet-280	197	33	udp	udp	NOUN
admet-280	197	34	-	-	NOUN
admet-280	197	35	glucuronosyltransferases	glucuronosyltransferase	NOUN
admet-280	197	36	(	(	PUNCT
admet-280	197	37	ugt	ugt	PROPN
admet-280	197	38	)	)	PUNCT
admet-280	197	39	and	and	CCONJ
admet-280	197	40	glutathione	glutathione	NOUN
admet-280	197	41	-	-	PUNCT
admet-280	197	42	s	s	NOUN
admet-280	197	43	-	-	PUNCT
admet-280	197	44	transferases	transferase	NOUN
admet-280	197	45	(	(	PUNCT
admet-280	197	46	gst	gst	NOUN
admet-280	197	47	)	)	PUNCT
admet-280	197	48	were	be	AUX
admet-280	197	49	evaluated	evaluate	VERB
admet-280	197	50	.	.	PUNCT
admet-280	198	1	expression	expression	NOUN
admet-280	198	2	of	of	ADP
admet-280	198	3	ugt2b7	ugt2b7	NOUN
admet-280	198	4	in	in	ADP
admet-280	198	5	scdhs	scdhs	PROPN
admet-280	198	6	was	be	AUX
admet-280	198	7	comparable	comparable	ADJ
admet-280	198	8	to	to	ADP
admet-280	198	9	fetal	fetal	ADJ
admet-280	198	10	liver	liver	NOUN
admet-280	198	11	tissue	tissue	NOUN
admet-280	198	12	(	(	PUNCT
admet-280	198	13	figure	figure	NOUN
admet-280	198	14	2	2	NUM
admet-280	198	15	)	)	PUNCT
admet-280	198	16	.	.	PUNCT
admet-280	199	1	expression	expression	NOUN
admet-280	199	2	of	of	ADP
admet-280	199	3	ugt1a1	ugt1a1	NOUN
admet-280	199	4	in	in	ADP
admet-280	199	5	scdhs	scdhs	PROPN
admet-280	199	6	was	be	AUX
admet-280	199	7	comparable	comparable	ADJ
admet-280	199	8	to	to	ADP
admet-280	199	9	expression	expression	NOUN
admet-280	199	10	in	in	ADP
admet-280	199	11	both	both	CCONJ
admet-280	199	12	fetal	fetal	ADJ
admet-280	199	13	and	and	CCONJ
admet-280	199	14	adult	adult	NOUN
admet-280	199	15	liver	liver	NOUN
admet-280	199	16	tissue	tissue	NOUN
admet-280	199	17	and	and	CCONJ
admet-280	199	18	ugt1a6	ugt1a6	NOUN
admet-280	199	19	expression	expression	NOUN
admet-280	199	20	was	be	AUX
admet-280	199	21	comparable	comparable	ADJ
admet-280	199	22	to	to	ADP
admet-280	199	23	that	that	PRON
admet-280	199	24	in	in	ADP
admet-280	199	25	adult	adult	NOUN
admet-280	199	26	liver	liver	NOUN
admet-280	199	27	tissue	tissue	NOUN
admet-280	199	28	(	(	PUNCT
admet-280	199	29	supplemental	supplemental	ADJ
admet-280	199	30	figure	figure	NOUN
admet-280	199	31	1	1	NUM
admet-280	199	32	)	)	PUNCT
admet-280	199	33	.	.	PUNCT
admet-280	200	1	in	in	ADP
admet-280	200	2	contrast	contrast	NOUN
admet-280	200	3	,	,	PUNCT
admet-280	200	4	expression	expression	NOUN
admet-280	200	5	of	of	ADP
admet-280	200	6	ugt2b4	ugt2b4	NOUN
admet-280	200	7	in	in	ADP
admet-280	200	8	scdhs	scdhs	NOUN
admet-280	200	9	was	be	AUX
admet-280	200	10	below	below	ADP
admet-280	200	11	that	that	PRON
admet-280	200	12	of	of	ADP
admet-280	200	13	both	both	CCONJ
admet-280	200	14	fetal	fetal	ADJ
admet-280	200	15	and	and	CCONJ
admet-280	200	16	adult	adult	NOUN
admet-280	200	17	liver	liver	NOUN
admet-280	200	18	tissue	tissue	NOUN
admet-280	200	19	(	(	PUNCT
admet-280	200	20	supplemental	supplemental	ADJ
admet-280	200	21	figure	figure	NOUN
admet-280	200	22	1	1	NUM
admet-280	200	23	)	)	PUNCT
admet-280	200	24	.	.	PUNCT
admet-280	201	1	in	in	ADP
admet-280	201	2	general	general	ADJ
admet-280	201	3	,	,	PUNCT
admet-280	201	4	for	for	ADP
admet-280	201	5	gstt1	gstt1	NOUN
admet-280	201	6	,	,	PUNCT
admet-280	201	7	gstm1	gstm1	NOUN
admet-280	201	8	and	and	CCONJ
admet-280	201	9	gstp1	gstp1	NOUN
admet-280	201	10	there	there	PRON
admet-280	201	11	was	be	VERB
admet-280	201	12	largely	largely	ADV
admet-280	201	13	no	no	DET
admet-280	201	14	difference	difference	NOUN
admet-280	201	15	in	in	ADP
admet-280	201	16	expression	expression	NOUN
admet-280	201	17	between	between	ADP
admet-280	201	18	stem	stem	NOUN
admet-280	201	19	cells	cell	NOUN
admet-280	201	20	and	and	CCONJ
admet-280	201	21	scdhs	scdhs	ADJ
admet-280	201	22	(	(	PUNCT
admet-280	201	23	supplemental	supplemental	ADJ
admet-280	201	24	figure	figure	NOUN
admet-280	201	25	1	1	NUM
admet-280	201	26	)	)	PUNCT
admet-280	201	27	.	.	PUNCT
admet-280	202	1	for	for	ADP
admet-280	202	2	the	the	DET
admet-280	202	3	h1	h1	PROPN
admet-280	202	4	and	and	CCONJ
admet-280	202	5	h9	h9	NOUN
admet-280	202	6	cell	cell	NOUN
admet-280	202	7	lines	line	NOUN
admet-280	202	8	evaluated	evaluate	VERB
admet-280	202	9	in	in	ADP
admet-280	202	10	the	the	DET
admet-280	202	11	gene	gene	NOUN
admet-280	202	12	expression	expression	NOUN
admet-280	202	13	profiling	profiling	NOUN
admet-280	202	14	,	,	PUNCT
admet-280	202	15	no	no	DET
admet-280	202	16	polymorphisms	polymorphism	NOUN
admet-280	202	17	for	for	ADP
admet-280	202	18	the	the	DET
admet-280	202	19	gsts	gst	NOUN
admet-280	202	20	were	be	AUX
admet-280	202	21	detected	detect	VERB
admet-280	202	22	in	in	ADP
admet-280	202	23	the	the	DET
admet-280	202	24	dmet	dmet	NOUN
admet-280	202	25	genotyping	genotype	VERB
admet-280	202	26	analysis	analysis	NOUN
admet-280	202	27	.	.	PUNCT
admet-280	203	1	to	to	PART
admet-280	203	2	examine	examine	VERB
admet-280	203	3	the	the	DET
admet-280	203	4	expression	expression	NOUN
admet-280	203	5	of	of	ADP
admet-280	203	6	drug	drug	NOUN
admet-280	203	7	transporters	transporter	NOUN
admet-280	203	8	in	in	ADP
admet-280	203	9	scdhs	scdhs	ADJ
admet-280	203	10	,	,	PUNCT
admet-280	203	11	p	p	NOUN
admet-280	203	12	-	-	PUNCT
admet-280	203	13	gp	gp	NOUN
admet-280	203	14	,	,	PUNCT
admet-280	203	15	bcrp	bcrp	ADV
admet-280	203	16	,	,	PUNCT
admet-280	203	17	mrp2	mrp2	PROPN
admet-280	203	18	,	,	PUNCT
admet-280	203	19	oatp1b1	oatp1b1	NUM
admet-280	203	20	,	,	PUNCT
admet-280	203	21	oatp1b3	oatp1b3	NOUN
admet-280	203	22	,	,	PUNCT
admet-280	203	23	and	and	CCONJ
admet-280	203	24	atp7b	atp7b	PROPN
admet-280	203	25	mrna	mrna	PROPN
admet-280	203	26	levels	level	NOUN
admet-280	203	27	were	be	AUX
admet-280	203	28	measured	measure	VERB
admet-280	203	29	.	.	PUNCT
admet-280	204	1	atp7b	atp7b	PROPN
admet-280	204	2	is	be	AUX
admet-280	204	3	a	a	DET
admet-280	204	4	copper	copper	NOUN
admet-280	204	5	transporting	transport	VERB
admet-280	204	6	atpase	atpase	PROPN
admet-280	204	7	expressed	express	VERB
admet-280	204	8	in	in	ADP
admet-280	204	9	the	the	DET
admet-280	204	10	liver	liver	NOUN
admet-280	204	11	,	,	PUNCT
admet-280	204	12	and	and	CCONJ
admet-280	204	13	is	be	AUX
admet-280	204	14	responsible	responsible	ADJ
admet-280	204	15	for	for	ADP
admet-280	204	16	transporting	transport	VERB
admet-280	204	17	copper	copper	NOUN
admet-280	204	18	from	from	ADP
admet-280	204	19	hepatocytes	hepatocyte	NOUN
admet-280	204	20	into	into	ADP
admet-280	204	21	the	the	DET
admet-280	204	22	bile	bile	NOUN
admet-280	204	23	[	[	X
admet-280	204	24	47	47	NUM
admet-280	204	25	]	]	PUNCT
admet-280	204	26	.	.	PUNCT
admet-280	205	1	mutations	mutation	NOUN
admet-280	205	2	in	in	ADP
admet-280	205	3	atp7b	atp7b	PROPN
admet-280	205	4	are	be	AUX
admet-280	205	5	associated	associate	VERB
admet-280	205	6	with	with	ADP
admet-280	205	7	wilson	wilson	PROPN
admet-280	205	8	’s	’s	PART
admet-280	205	9	disease	disease	NOUN
admet-280	205	10	,	,	PUNCT
admet-280	205	11	a	a	DET
admet-280	205	12	disorder	disorder	NOUN
admet-280	205	13	in	in	ADP
admet-280	205	14	copper	copper	NOUN
admet-280	205	15	metabolism	metabolism	NOUN
admet-280	205	16	with	with	ADP
admet-280	205	17	manifestations	manifestation	NOUN
admet-280	205	18	in	in	ADP
admet-280	205	19	the	the	DET
admet-280	205	20	liver	liver	NOUN
admet-280	205	21	and	and	CCONJ
admet-280	205	22	the	the	DET
admet-280	205	23	brain	brain	NOUN
admet-280	206	1	[	[	X
admet-280	206	2	47	47	NUM
admet-280	206	3	]	]	PUNCT
admet-280	206	4	.	.	PUNCT
admet-280	207	1	expression	expression	NOUN
admet-280	207	2	of	of	ADP
admet-280	207	3	atp7b	atp7b	PROPN
admet-280	207	4	was	be	AUX
admet-280	207	5	up	up	ADV
admet-280	207	6	-	-	PUNCT
admet-280	207	7	regulated	regulate	VERB
admet-280	207	8	in	in	ADP
admet-280	207	9	scdhs	scdhs	ADJ
admet-280	207	10	,	,	PUNCT
admet-280	207	11	compared	compare	VERB
admet-280	207	12	to	to	ADP
admet-280	207	13	stem	stem	NOUN
admet-280	207	14	cells	cell	NOUN
admet-280	207	15	.	.	PUNCT
admet-280	208	1	the	the	DET
admet-280	208	2	expression	expression	NOUN
admet-280	208	3	in	in	ADP
admet-280	208	4	scdhs	scdhs	PROPN
admet-280	208	5	was	be	AUX
admet-280	208	6	slightly	slightly	ADV
admet-280	208	7	higher	high	ADJ
admet-280	208	8	than	than	ADP
admet-280	208	9	differentiated	differentiated	ADJ
admet-280	208	10	heparg	heparg	NOUN
admet-280	208	11	cells	cell	NOUN
admet-280	208	12	,	,	PUNCT
admet-280	208	13	fetal	fetal	ADJ
admet-280	208	14	and	and	CCONJ
admet-280	208	15	adult	adult	NOUN
admet-280	208	16	liver	liver	NOUN
admet-280	208	17	tissue	tissue	NOUN
admet-280	208	18	(	(	PUNCT
admet-280	208	19	supplemental	supplemental	ADJ
admet-280	208	20	figure	figure	NOUN
admet-280	208	21	1	1	NUM
admet-280	208	22	)	)	PUNCT
admet-280	208	23	.	.	PUNCT
admet-280	209	1	p	p	X
admet-280	209	2	-	-	PUNCT
admet-280	209	3	gp	gp	NOUN
admet-280	209	4	was	be	AUX
admet-280	209	5	expressed	express	VERB
admet-280	209	6	in	in	ADP
admet-280	209	7	scdhs	scdhs	NOUN
admet-280	209	8	at	at	ADP
admet-280	209	9	levels	level	NOUN
admet-280	209	10	comparable	comparable	ADJ
admet-280	209	11	to	to	ADP
admet-280	209	12	that	that	PRON
admet-280	209	13	in	in	ADP
admet-280	209	14	fetal	fetal	ADJ
admet-280	209	15	liver	liver	NOUN
admet-280	209	16	tissue	tissue	NOUN
admet-280	209	17	and	and	CCONJ
admet-280	209	18	below	below	ADP
admet-280	209	19	heparg	heparg	NOUN
admet-280	209	20	differentiated	differentiate	VERB
admet-280	209	21	cells	cell	NOUN
admet-280	209	22	and	and	CCONJ
admet-280	209	23	adult	adult	NOUN
admet-280	209	24	liver	liver	NOUN
admet-280	209	25	tissue	tissue	NOUN
admet-280	209	26	(	(	PUNCT
admet-280	209	27	figure	figure	NOUN
admet-280	209	28	2	2	NUM
admet-280	209	29	)	)	PUNCT
admet-280	209	30	.	.	PUNCT
admet-280	210	1	bcrp	bcrp	PROPN
admet-280	210	2	expression	expression	NOUN
admet-280	210	3	was	be	AUX
admet-280	210	4	higher	high	ADJ
admet-280	210	5	in	in	ADP
admet-280	210	6	scdhs	scdhs	NOUN
admet-280	210	7	compared	compare	VERB
admet-280	210	8	to	to	ADP
admet-280	210	9	heparg	heparg	NOUN
admet-280	210	10	cells	cell	NOUN
admet-280	210	11	,	,	PUNCT
admet-280	210	12	fetal	fetal	ADJ
admet-280	210	13	and	and	CCONJ
admet-280	210	14	adult	adult	NOUN
admet-280	210	15	liver	liver	NOUN
admet-280	210	16	tissue	tissue	NOUN
admet-280	210	17	(	(	PUNCT
admet-280	210	18	figure	figure	NOUN
admet-280	210	19	2	2	NUM
admet-280	210	20	)	)	PUNCT
admet-280	210	21	.	.	PUNCT
admet-280	211	1	expression	expression	NOUN
admet-280	211	2	of	of	ADP
admet-280	211	3	oatp1b1	oatp1b1	NOUN
admet-280	211	4	and	and	CCONJ
admet-280	211	5	oatp1b3	oatp1b3	NOUN
admet-280	211	6	was	be	AUX
admet-280	211	7	minimal	minimal	ADJ
admet-280	211	8	in	in	ADP
admet-280	211	9	scdhs	scdhs	ADJ
admet-280	211	10	,	,	PUNCT
admet-280	211	11	and	and	CCONJ
admet-280	211	12	well	well	ADV
admet-280	211	13	below	below	ADP
admet-280	211	14	that	that	PRON
admet-280	211	15	in	in	ADP
admet-280	211	16	fetal	fetal	ADJ
admet-280	211	17	and	and	CCONJ
admet-280	211	18	adult	adult	NOUN
admet-280	211	19	liver	liver	NOUN
admet-280	211	20	tissue	tissue	NOUN
admet-280	211	21	(	(	PUNCT
admet-280	211	22	supplemental	supplemental	ADJ
admet-280	211	23	figure	figure	NOUN
admet-280	211	24	1	1	NUM
admet-280	211	25	)	)	PUNCT
admet-280	211	26	.	.	PUNCT
admet-280	212	1	lastly	lastly	ADV
admet-280	212	2	,	,	PUNCT
admet-280	212	3	while	while	SCONJ
admet-280	212	4	mrp2	mrp2	PROPN
admet-280	212	5	mrna	mrna	PROPN
admet-280	212	6	was	be	AUX
admet-280	212	7	detected	detect	VERB
admet-280	212	8	in	in	ADP
admet-280	212	9	scdhs	scdhs	PROPN
admet-280	212	10	,	,	PUNCT
admet-280	212	11	it	it	PRON
admet-280	212	12	was	be	AUX
admet-280	212	13	below	below	ADP
admet-280	212	14	the	the	DET
admet-280	212	15	expression	expression	NOUN
admet-280	212	16	levels	level	NOUN
admet-280	212	17	in	in	ADP
admet-280	212	18	heparg	heparg	NOUN
admet-280	212	19	cells	cell	NOUN
admet-280	212	20	,	,	PUNCT
admet-280	212	21	fetal	fetal	ADJ
admet-280	212	22	and	and	CCONJ
admet-280	212	23	adult	adult	NOUN
admet-280	212	24	liver	liver	NOUN
admet-280	212	25	tissue	tissue	NOUN
admet-280	212	26	(	(	PUNCT
admet-280	212	27	supplemental	supplemental	ADJ
admet-280	212	28	figure	figure	NOUN
admet-280	212	29	1	1	NUM
admet-280	212	30	)	)	PUNCT
admet-280	212	31	.	.	PUNCT
admet-280	213	1	similar	similar	ADJ
admet-280	213	2	to	to	ADP
admet-280	213	3	the	the	DET
admet-280	213	4	other	other	ADJ
admet-280	213	5	results	result	NOUN
admet-280	213	6	obtained	obtain	VERB
admet-280	213	7	for	for	ADP
admet-280	213	8	gene	gene	NOUN
admet-280	213	9	expression	expression	NOUN
admet-280	213	10	,	,	PUNCT
admet-280	213	11	some	some	DET
admet-280	213	12	transporters	transporter	NOUN
admet-280	213	13	were	be	AUX
admet-280	213	14	minimally	minimally	ADV
admet-280	213	15	expressed	express	VERB
admet-280	213	16	(	(	PUNCT
admet-280	213	17	oatp1b1	oatp1b1	NUM
admet-280	213	18	,	,	PUNCT
admet-280	213	19	oatp1b3	oatp1b3	NOUN
admet-280	213	20	,	,	PUNCT
admet-280	213	21	mrp2	mrp2	PROPN
admet-280	213	22	)	)	PUNCT
admet-280	213	23	,	,	PUNCT
admet-280	213	24	while	while	SCONJ
admet-280	213	25	some	some	PRON
admet-280	213	26	were	be	AUX
admet-280	213	27	similar	similar	ADJ
admet-280	213	28	to	to	ADP
admet-280	213	29	that	that	PRON
admet-280	213	30	in	in	ADP
admet-280	213	31	fetal	fetal	ADJ
admet-280	213	32	liver	liver	NOUN
admet-280	213	33	tissue	tissue	NOUN
admet-280	213	34	(	(	PUNCT
admet-280	213	35	p	p	NOUN
admet-280	213	36	-	-	PUNCT
admet-280	213	37	gp	gp	NOUN
admet-280	213	38	and	and	CCONJ
admet-280	213	39	atp7b	atp7b	PROPN
admet-280	213	40	)	)	PUNCT
admet-280	213	41	,	,	PUNCT
admet-280	213	42	with	with	ADP
admet-280	213	43	the	the	DET
admet-280	213	44	exception	exception	NOUN
admet-280	213	45	of	of	ADP
admet-280	213	46	bcrp	bcrp	ADV
admet-280	213	47	which	which	PRON
admet-280	213	48	was	be	AUX
admet-280	213	49	highly	highly	ADV
admet-280	213	50	expressed	express	VERB
admet-280	213	51	in	in	ADP
admet-280	213	52	scdhs	scdhs	PROPN
admet-280	213	53	.	.	PUNCT
admet-280	214	1	figure	figure	NOUN
admet-280	214	2	3	3	NUM
admet-280	214	3	.	.	PUNCT
admet-280	215	1	cyp3a	cyp3a	NOUN
admet-280	215	2	induction	induction	NOUN
admet-280	215	3	.	.	PUNCT
admet-280	216	1	qrt	qrt	ADJ
admet-280	216	2	-	-	PUNCT
admet-280	216	3	pcr	pcr	ADJ
admet-280	216	4	results	result	NOUN
admet-280	216	5	for	for	ADP
admet-280	216	6	scdhs	scdhs	ADJ
admet-280	216	7	incubated	incubate	VERB
admet-280	216	8	with	with	ADP
admet-280	216	9	the	the	DET
admet-280	216	10	inducer	inducer	NOUN
admet-280	216	11	rifampicin	rifampicin	VERB
admet-280	216	12	or	or	CCONJ
admet-280	216	13	phenobarbital	phenobarbital	ADJ
admet-280	216	14	,	,	PUNCT
admet-280	216	15	shown	show	VERB
admet-280	216	16	as	as	ADP
admet-280	216	17	fold	fold	ADJ
admet-280	216	18	change	change	NOUN
admet-280	216	19	compared	compare	VERB
admet-280	216	20	to	to	PART
admet-280	216	21	scdhs	scdhs	VERB
admet-280	216	22	incubated	incubate	VERB
admet-280	216	23	with	with	ADP
admet-280	216	24	dmso	dmso	NOUN
admet-280	216	25	,	,	PUNCT
admet-280	216	26	which	which	PRON
admet-280	216	27	was	be	AUX
admet-280	216	28	set	set	VERB
admet-280	216	29	to	to	ADP
admet-280	216	30	1	1	NUM
admet-280	216	31	.	.	PUNCT
admet-280	217	1	gus	gus	NOUN
admet-280	217	2	-	-	PUNCT
admet-280	217	3	b	b	PROPN
admet-280	217	4	was	be	AUX
admet-280	217	5	used	use	VERB
admet-280	217	6	as	as	ADP
admet-280	217	7	a	a	DET
admet-280	217	8	housekeeping	housekeeping	NOUN
admet-280	217	9	gene	gene	NOUN
admet-280	217	10	.	.	PUNCT
admet-280	218	1	scdh	scdh	PROPN
admet-280	218	2	rif	rif	PROPN
admet-280	218	3	represents	represents	AUX
admet-280	218	4	scdhs	scdhs	ADV
admet-280	218	5	incubated	incubate	VERB
admet-280	218	6	with	with	ADP
admet-280	218	7	rifampicin	rifampicin	NOUN
admet-280	218	8	;	;	PUNCT
admet-280	218	9	scdh	scdh	NOUN
admet-280	218	10	pheno	pheno	NOUN
admet-280	218	11	represents	represents	AUX
admet-280	218	12	scdhs	scdhs	ADV
admet-280	218	13	incubated	incubate	VERB
admet-280	218	14	with	with	ADP
admet-280	218	15	phenobarbital	phenobarbital	ADJ
admet-280	218	16	.	.	PUNCT
admet-280	219	1	scdhs	scdhs	PROPN
admet-280	219	2	were	be	AUX
admet-280	219	3	incubated	incubate	VERB
admet-280	219	4	with	with	ADP
admet-280	219	5	the	the	DET
admet-280	219	6	canonical	canonical	ADJ
admet-280	219	7	inducers	inducer	NOUN
admet-280	219	8	rifampicin	rifampicin	VERB
admet-280	219	9	and	and	CCONJ
admet-280	219	10	phenobarbital	phenobarbital	ADJ
admet-280	219	11	and	and	CCONJ
admet-280	219	12	effects	effect	NOUN
admet-280	219	13	on	on	ADP
admet-280	219	14	cyp3a4	cyp3a4	PROPN
admet-280	219	15	,	,	PUNCT
admet-280	219	16	cyp3a7	cyp3a7	NOUN
admet-280	219	17	,	,	PUNCT
admet-280	219	18	car	car	NOUN
admet-280	219	19	and	and	CCONJ
admet-280	219	20	pxr	pxr	NOUN
admet-280	219	21	expression	expression	NOUN
admet-280	219	22	were	be	AUX
admet-280	219	23	evaluated	evaluate	VERB
admet-280	219	24	.	.	PUNCT
admet-280	220	1	results	result	NOUN
admet-280	220	2	are	be	AUX
admet-280	220	3	reported	report	VERB
admet-280	220	4	as	as	ADP
admet-280	220	5	fold	fold	ADJ
admet-280	220	6	change	change	NOUN
admet-280	220	7	compared	compare	VERB
admet-280	220	8	to	to	ADP
admet-280	220	9	scdhs	scdhs	VERB
admet-280	220	10	voellinger	voellinger	NOUN
admet-280	220	11	and	and	CCONJ
admet-280	220	12	kelly	kelly	PROPN
admet-280	220	13	admet	admet	PROPN
admet-280	220	14	&	&	CCONJ
admet-280	220	15	dmpk	dmpk	PROPN
admet-280	220	16	4(2	4(2	NUM
admet-280	220	17	)	)	PUNCT
admet-280	220	18	(	(	PUNCT
admet-280	220	19	2016	2016	NUM
admet-280	220	20	)	)	PUNCT
admet-280	220	21	62	62	NUM
admet-280	220	22	-	-	SYM
admet-280	220	23	83	83	NUM
admet-280	220	24	72	72	NUM
admet-280	220	25	incubated	incubate	VERB
admet-280	220	26	with	with	ADP
admet-280	220	27	a	a	DET
admet-280	220	28	dmso	dmso	ADJ
admet-280	220	29	vehicle	vehicle	NOUN
admet-280	220	30	control	control	NOUN
admet-280	220	31	(	(	PUNCT
admet-280	220	32	figure	figure	NOUN
admet-280	220	33	3	3	NUM
admet-280	220	34	)	)	PUNCT
admet-280	220	35	.	.	PUNCT
admet-280	221	1	in	in	ADP
admet-280	221	2	this	this	DET
admet-280	221	3	instance	instance	NOUN
admet-280	221	4	,	,	PUNCT
admet-280	221	5	basal	basal	ADJ
admet-280	221	6	expression	expression	NOUN
admet-280	221	7	of	of	ADP
admet-280	221	8	cyps	cyps	PROPN
admet-280	221	9	3a4	3a4	NUM
admet-280	221	10	and	and	CCONJ
admet-280	221	11	3a7	3a7	NUM
admet-280	221	12	was	be	AUX
admet-280	221	13	detected	detect	VERB
admet-280	221	14	in	in	ADP
admet-280	221	15	scdhs	scdhs	PROPN
admet-280	221	16	.	.	PUNCT
admet-280	222	1	cyp3a4	cyp3a4	NOUN
admet-280	222	2	expression	expression	NOUN
admet-280	222	3	was	be	AUX
admet-280	222	4	induced	induce	VERB
admet-280	222	5	by	by	ADP
admet-280	222	6	rifampicin	rifampicin	VERB
admet-280	222	7	and	and	CCONJ
admet-280	222	8	phenobarbital	phenobarbital	ADJ
admet-280	222	9	.	.	PUNCT
admet-280	223	1	phenobarbital	phenobarbital	ADJ
admet-280	223	2	induced	induce	VERB
admet-280	223	3	cyp3a4	cyp3a4	NOUN
admet-280	223	4	in	in	ADP
admet-280	223	5	scdhs	scdhs	PROPN
admet-280	223	6	to	to	ADP
admet-280	223	7	levels	level	NOUN
admet-280	223	8	comparable	comparable	ADJ
admet-280	223	9	with	with	ADP
admet-280	223	10	a	a	DET
admet-280	223	11	fetal	fetal	ADJ
admet-280	223	12	liver	liver	NOUN
admet-280	223	13	tissue	tissue	NOUN
admet-280	223	14	sample	sample	NOUN
admet-280	223	15	.	.	PUNCT
admet-280	224	1	cyp3a7	cyp3a7	NOUN
admet-280	224	2	and	and	CCONJ
admet-280	224	3	car	car	NOUN
admet-280	224	4	expression	expression	NOUN
admet-280	224	5	was	be	AUX
admet-280	224	6	induced	induce	VERB
admet-280	224	7	by	by	ADP
admet-280	224	8	phenobarbital	phenobarbital	ADJ
admet-280	224	9	.	.	PUNCT
admet-280	225	1	phenobarbital	phenobarbital	PROPN
admet-280	225	2	induced	induce	VERB
admet-280	225	3	cyp3a7	cyp3a7	NOUN
admet-280	225	4	in	in	ADP
admet-280	225	5	scdhs	scdhs	PROPN
admet-280	225	6	to	to	ADP
admet-280	225	7	levels	level	NOUN
admet-280	225	8	comparable	comparable	ADJ
admet-280	225	9	with	with	ADP
admet-280	225	10	an	an	DET
admet-280	225	11	adult	adult	NOUN
admet-280	225	12	liver	liver	NOUN
admet-280	225	13	tissue	tissue	NOUN
admet-280	225	14	sample	sample	NOUN
admet-280	225	15	.	.	PUNCT
admet-280	226	1	the	the	DET
admet-280	226	2	gene	gene	NOUN
admet-280	226	3	expression	expression	NOUN
admet-280	226	4	results	result	NOUN
admet-280	226	5	reported	report	VERB
admet-280	226	6	here	here	ADV
admet-280	226	7	indicate	indicate	VERB
admet-280	226	8	scdhs	scdhs	PROPN
admet-280	226	9	are	be	AUX
admet-280	226	10	capable	capable	ADJ
admet-280	226	11	of	of	ADP
admet-280	226	12	responding	respond	VERB
admet-280	226	13	to	to	ADP
admet-280	226	14	the	the	DET
admet-280	226	15	inducers	inducer	NOUN
admet-280	226	16	rifampicin	rifampicin	VERB
admet-280	226	17	and	and	CCONJ
admet-280	226	18	phenobarbital	phenobarbital	ADJ
admet-280	226	19	.	.	PUNCT
admet-280	227	1	overall	overall	ADJ
admet-280	227	2	,	,	PUNCT
admet-280	227	3	gene	gene	NOUN
admet-280	227	4	expression	expression	NOUN
admet-280	227	5	profiling	profiling	NOUN
admet-280	227	6	of	of	ADP
admet-280	227	7	scdhs	scdhs	ADJ
admet-280	227	8	indicates	indicate	VERB
admet-280	227	9	they	they	PRON
admet-280	227	10	are	be	AUX
admet-280	227	11	largely	largely	ADV
admet-280	227	12	immature	immature	ADJ
admet-280	227	13	hepatocytes	hepatocyte	NOUN
admet-280	227	14	,	,	PUNCT
admet-280	227	15	especially	especially	ADV
admet-280	227	16	with	with	ADP
admet-280	227	17	regard	regard	NOUN
admet-280	227	18	to	to	ADP
admet-280	227	19	the	the	DET
admet-280	227	20	cyp	cyp	ADJ
admet-280	227	21	enzymes	enzyme	NOUN
admet-280	227	22	.	.	PUNCT
admet-280	228	1	with	with	ADP
admet-280	228	2	regards	regard	NOUN
admet-280	228	3	to	to	ADP
admet-280	228	4	afp	afp	PROPN
admet-280	228	5	,	,	PUNCT
admet-280	228	6	cyp3a7	cyp3a7	NOUN
admet-280	228	7	and	and	CCONJ
admet-280	228	8	fmo1	fmo1	NOUN
admet-280	228	9	expression	expression	NOUN
admet-280	228	10	,	,	PUNCT
admet-280	228	11	scdhs	scdhs	PROPN
admet-280	228	12	appear	appear	VERB
admet-280	228	13	to	to	AUX
admet-280	228	14	more	more	ADV
admet-280	228	15	closely	closely	ADV
admet-280	228	16	resemble	resemble	VERB
admet-280	228	17	fetal	fetal	ADJ
admet-280	228	18	hepatocytes	hepatocyte	NOUN
admet-280	228	19	.	.	PUNCT
admet-280	229	1	this	this	PRON
admet-280	229	2	suggests	suggest	VERB
admet-280	229	3	that	that	SCONJ
admet-280	229	4	even	even	ADV
admet-280	229	5	though	though	SCONJ
admet-280	229	6	scdhs	scdhs	ADJ
admet-280	229	7	are	be	AUX
admet-280	229	8	not	not	PART
admet-280	229	9	currently	currently	ADV
admet-280	229	10	in	in	ADP
admet-280	229	11	a	a	DET
admet-280	229	12	fully	fully	ADV
admet-280	229	13	differentiated	differentiate	VERB
admet-280	229	14	,	,	PUNCT
admet-280	229	15	or	or	CCONJ
admet-280	229	16	mature	mature	ADJ
admet-280	229	17	,	,	PUNCT
admet-280	229	18	state	state	NOUN
admet-280	229	19	they	they	PRON
admet-280	229	20	may	may	AUX
admet-280	229	21	be	be	AUX
admet-280	229	22	useful	useful	ADJ
admet-280	229	23	in	in	ADP
admet-280	229	24	studying	study	VERB
admet-280	229	25	drug	drug	NOUN
admet-280	229	26	-	-	PUNCT
admet-280	229	27	metabolism	metabolism	NOUN
admet-280	229	28	in	in	ADP
admet-280	229	29	neonates	neonate	NOUN
admet-280	229	30	,	,	PUNCT
admet-280	229	31	or	or	CCONJ
admet-280	229	32	potentially	potentially	ADV
admet-280	229	33	as	as	ADP
admet-280	229	34	a	a	DET
admet-280	229	35	test	test	NOUN
admet-280	229	36	system	system	NOUN
admet-280	229	37	to	to	PART
admet-280	229	38	investigate	investigate	VERB
admet-280	229	39	the	the	DET
admet-280	229	40	ontogeny	ontogeny	NOUN
admet-280	229	41	of	of	ADP
admet-280	229	42	drug	drug	NOUN
admet-280	229	43	-	-	PUNCT
admet-280	229	44	metabolizing	metabolize	VERB
admet-280	229	45	enzymes	enzyme	NOUN
admet-280	229	46	.	.	PUNCT
admet-280	230	1	however	however	ADV
admet-280	230	2	,	,	PUNCT
admet-280	230	3	further	further	ADJ
admet-280	230	4	investigation	investigation	NOUN
admet-280	230	5	of	of	ADP
admet-280	230	6	drug	drug	NOUN
admet-280	230	7	-	-	PUNCT
admet-280	230	8	metabolizing	metabolize	VERB
admet-280	230	9	enzyme	enzyme	NOUN
admet-280	230	10	expression	expression	NOUN
admet-280	230	11	throughout	throughout	ADP
admet-280	230	12	the	the	DET
admet-280	230	13	differentiation	differentiation	NOUN
admet-280	230	14	process	process	NOUN
admet-280	230	15	and	and	CCONJ
admet-280	230	16	comparison	comparison	NOUN
admet-280	230	17	to	to	ADP
admet-280	230	18	a	a	DET
admet-280	230	19	more	more	ADV
admet-280	230	20	extensive	extensive	ADJ
admet-280	230	21	sampling	sampling	NOUN
admet-280	230	22	of	of	ADP
admet-280	230	23	fetal	fetal	ADJ
admet-280	230	24	tissues	tissue	NOUN
admet-280	230	25	at	at	ADP
admet-280	230	26	different	different	ADJ
admet-280	230	27	ages	age	NOUN
admet-280	230	28	than	than	SCONJ
admet-280	230	29	what	what	PRON
admet-280	230	30	was	be	AUX
admet-280	230	31	utilized	utilize	VERB
admet-280	230	32	in	in	ADP
admet-280	230	33	this	this	DET
admet-280	230	34	study	study	NOUN
admet-280	230	35	would	would	AUX
admet-280	230	36	be	be	AUX
admet-280	230	37	warranted	warrant	VERB
admet-280	230	38	.	.	PUNCT
admet-280	231	1	if	if	SCONJ
admet-280	231	2	scdhs	scdhs	ADJ
admet-280	231	3	are	be	AUX
admet-280	231	4	to	to	PART
admet-280	231	5	be	be	AUX
admet-280	231	6	used	use	VERB
admet-280	231	7	in	in	ADP
admet-280	231	8	conjunction	conjunction	NOUN
admet-280	231	9	with	with	ADP
admet-280	231	10	,	,	PUNCT
admet-280	231	11	or	or	CCONJ
admet-280	231	12	as	as	ADP
admet-280	231	13	an	an	DET
admet-280	231	14	alternative	alternative	NOUN
admet-280	231	15	to	to	ADP
admet-280	231	16	,	,	PUNCT
admet-280	231	17	cryopreserved	cryopreserve	VERB
admet-280	231	18	hepatocytes	hepatocyte	NOUN
admet-280	231	19	a	a	DET
admet-280	231	20	differentiation	differentiation	NOUN
admet-280	231	21	protocol	protocol	NOUN
admet-280	231	22	that	that	PRON
admet-280	231	23	generates	generate	VERB
admet-280	231	24	more	more	ADV
admet-280	231	25	mature	mature	ADJ
admet-280	231	26	hepatocytes	hepatocyte	NOUN
admet-280	231	27	is	be	AUX
admet-280	231	28	needed	need	VERB
admet-280	231	29	.	.	PUNCT
admet-280	232	1	one	one	NUM
admet-280	232	2	potential	potential	ADJ
admet-280	232	3	method	method	NOUN
admet-280	232	4	that	that	PRON
admet-280	232	5	may	may	AUX
admet-280	232	6	enhance	enhance	VERB
admet-280	232	7	scdh	scdh	ADJ
admet-280	232	8	differentiation	differentiation	NOUN
admet-280	232	9	includes	include	VERB
admet-280	232	10	the	the	DET
admet-280	232	11	use	use	NOUN
admet-280	232	12	of	of	ADP
admet-280	232	13	small	small	ADJ
admet-280	232	14	molecules	molecule	NOUN
admet-280	232	15	in	in	ADP
admet-280	232	16	place	place	NOUN
admet-280	232	17	of	of	ADP
admet-280	232	18	less	less	ADV
admet-280	232	19	chemically	chemically	ADV
admet-280	232	20	defined	define	VERB
admet-280	232	21	proteins	protein	NOUN
admet-280	232	22	.	.	PUNCT
admet-280	233	1	another	another	DET
admet-280	233	2	method	method	NOUN
admet-280	233	3	that	that	PRON
admet-280	233	4	may	may	AUX
admet-280	233	5	enhance	enhance	VERB
admet-280	233	6	scdh	scdh	ADJ
admet-280	233	7	differentiation	differentiation	NOUN
admet-280	233	8	is	be	AUX
admet-280	233	9	the	the	DET
admet-280	233	10	manipulation	manipulation	NOUN
admet-280	233	11	of	of	ADP
admet-280	233	12	micrornas	microrna	NOUN
admet-280	233	13	(	(	PUNCT
admet-280	233	14	mirnas	mirna	NOUN
admet-280	233	15	)	)	PUNCT
admet-280	233	16	during	during	ADP
admet-280	233	17	the	the	DET
admet-280	233	18	cell	cell	NOUN
admet-280	233	19	culture	culture	NOUN
admet-280	233	20	process	process	NOUN
admet-280	233	21	that	that	PRON
admet-280	233	22	contribute	contribute	VERB
admet-280	233	23	to	to	ADP
admet-280	233	24	hepatocyte	hepatocyte	NOUN
admet-280	233	25	development	development	NOUN
admet-280	233	26	.	.	PUNCT
admet-280	234	1	mirnas	mirna	NOUN
admet-280	234	2	regulate	regulate	VERB
admet-280	234	3	many	many	ADJ
admet-280	234	4	genes	gene	NOUN
admet-280	234	5	,	,	PUNCT
admet-280	234	6	making	make	VERB
admet-280	234	7	them	they	PRON
admet-280	234	8	similar	similar	ADJ
admet-280	234	9	to	to	ADP
admet-280	234	10	transcription	transcription	NOUN
admet-280	234	11	factors	factor	NOUN
admet-280	234	12	,	,	PUNCT
admet-280	234	13	and	and	CCONJ
admet-280	234	14	therefore	therefore	ADV
admet-280	234	15	potential	potential	ADJ
admet-280	234	16	regulators	regulator	NOUN
admet-280	234	17	of	of	ADP
admet-280	234	18	cellular	cellular	ADJ
admet-280	234	19	processes	process	NOUN
admet-280	234	20	such	such	ADJ
admet-280	234	21	as	as	ADP
admet-280	234	22	differentiation	differentiation	NOUN
admet-280	234	23	.	.	PUNCT
admet-280	235	1	for	for	ADP
admet-280	235	2	example	example	NOUN
admet-280	235	3	,	,	PUNCT
admet-280	235	4	knockdown	knockdown	NOUN
admet-280	235	5	of	of	ADP
admet-280	235	6	mirnas	mirna	NOUN
admet-280	235	7	that	that	PRON
admet-280	235	8	may	may	AUX
admet-280	235	9	contribute	contribute	VERB
admet-280	235	10	to	to	ADP
admet-280	235	11	maintenance	maintenance	NOUN
admet-280	235	12	of	of	ADP
admet-280	235	13	a	a	DET
admet-280	235	14	pluripotent	pluripotent	NOUN
admet-280	235	15	,	,	PUNCT
admet-280	235	16	or	or	CCONJ
admet-280	235	17	stem	stem	NOUN
admet-280	235	18	cell	cell	NOUN
admet-280	235	19	state	state	NOUN
admet-280	235	20	,	,	PUNCT
admet-280	235	21	may	may	AUX
admet-280	235	22	allow	allow	VERB
admet-280	235	23	further	further	ADJ
admet-280	235	24	maturation	maturation	NOUN
admet-280	235	25	of	of	ADP
admet-280	235	26	scdhs	scdhs	NOUN
admet-280	235	27	.	.	PUNCT
admet-280	236	1	alternatively	alternatively	ADV
admet-280	236	2	,	,	PUNCT
admet-280	236	3	over	over	ADP
admet-280	236	4	-	-	PUNCT
admet-280	236	5	expression	expression	NOUN
admet-280	236	6	of	of	ADP
admet-280	236	7	mirnas	mirna	NOUN
admet-280	236	8	known	know	VERB
admet-280	236	9	to	to	PART
admet-280	236	10	normally	normally	ADV
admet-280	236	11	be	be	AUX
admet-280	236	12	expressed	express	VERB
admet-280	236	13	in	in	ADP
admet-280	236	14	mature	mature	ADJ
admet-280	236	15	hepatocytes	hepatocyte	NOUN
admet-280	236	16	may	may	AUX
admet-280	236	17	also	also	ADV
admet-280	236	18	allow	allow	VERB
admet-280	236	19	for	for	ADP
admet-280	236	20	further	further	ADJ
admet-280	236	21	maturation	maturation	NOUN
admet-280	236	22	of	of	ADP
admet-280	236	23	scdhs	scdhs	ADJ
admet-280	236	24	.	.	PUNCT
admet-280	237	1	lastly	lastly	ADV
admet-280	237	2	,	,	PUNCT
admet-280	237	3	there	there	PRON
admet-280	237	4	is	be	VERB
admet-280	237	5	the	the	DET
admet-280	237	6	potential	potential	NOUN
admet-280	237	7	of	of	ADP
admet-280	237	8	3d	3d	NUM
admet-280	237	9	culture	culture	NOUN
admet-280	237	10	systems	system	NOUN
admet-280	237	11	to	to	PART
admet-280	237	12	enhance	enhance	VERB
admet-280	237	13	scdh	scdh	NOUN
admet-280	237	14	differentiation	differentiation	NOUN
admet-280	237	15	and	and	CCONJ
admet-280	237	16	functional	functional	ADJ
admet-280	237	17	maturation	maturation	NOUN
admet-280	237	18	.	.	PUNCT
admet-280	238	1	culturing	culture	VERB
admet-280	238	2	the	the	DET
admet-280	238	3	scdhs	scdhs	NOUN
admet-280	238	4	in	in	ADP
admet-280	238	5	a	a	DET
admet-280	238	6	3d	3d	NOUN
admet-280	238	7	,	,	PUNCT
admet-280	238	8	or	or	CCONJ
admet-280	238	9	microphysiological	microphysiological	ADJ
admet-280	238	10	,	,	PUNCT
admet-280	238	11	culture	culture	NOUN
admet-280	238	12	system	system	NOUN
admet-280	238	13	that	that	PRON
admet-280	238	14	more	more	ADV
admet-280	238	15	closely	closely	ADV
admet-280	238	16	represents	represent	VERB
admet-280	238	17	the	the	DET
admet-280	238	18	true	true	ADJ
admet-280	238	19	in	in	ADP
admet-280	238	20	vivo	vivo	NOUN
admet-280	238	21	micro	micro	NOUN
admet-280	238	22	-	-	NOUN
admet-280	238	23	environment	environment	NOUN
admet-280	238	24	of	of	ADP
admet-280	238	25	a	a	DET
admet-280	238	26	hepatocyte	hepatocyte	NOUN
admet-280	238	27	is	be	AUX
admet-280	238	28	another	another	DET
admet-280	238	29	potential	potential	ADJ
admet-280	238	30	method	method	NOUN
admet-280	238	31	to	to	PART
admet-280	238	32	enhance	enhance	VERB
admet-280	238	33	scdh	scdh	ADJ
admet-280	238	34	differentiation	differentiation	NOUN
admet-280	238	35	.	.	PUNCT
admet-280	239	1	cyp	cyp	ADJ
admet-280	239	2	cocktail	cocktail	NOUN
admet-280	239	3	assay	assay	VERB
admet-280	239	4	to	to	PART
admet-280	239	5	assess	assess	VERB
admet-280	239	6	the	the	DET
admet-280	239	7	metabolic	metabolic	NOUN
admet-280	239	8	function	function	NOUN
admet-280	239	9	of	of	ADP
admet-280	239	10	the	the	DET
admet-280	239	11	cyp	cyp	ADJ
admet-280	239	12	enzymes	enzyme	NOUN
admet-280	239	13	in	in	ADP
admet-280	239	14	scdhs	scdhs	PROPN
admet-280	239	15	,	,	PUNCT
admet-280	239	16	a	a	DET
admet-280	239	17	cyp	cyp	ADJ
admet-280	239	18	cocktail	cocktail	NOUN
admet-280	239	19	assay	assay	NOUN
admet-280	239	20	was	be	AUX
admet-280	239	21	utilized	utilize	VERB
admet-280	239	22	and	and	CCONJ
admet-280	239	23	metabolite	metabolite	NOUN
admet-280	239	24	formation	formation	NOUN
admet-280	239	25	was	be	AUX
admet-280	239	26	measured	measure	VERB
admet-280	239	27	using	use	VERB
admet-280	239	28	lc	lc	PROPN
admet-280	239	29	-	-	PUNCT
admet-280	239	30	ms	ms	PROPN
admet-280	239	31	/	/	SYM
admet-280	239	32	ms	ms	PROPN
admet-280	239	33	.	.	PROPN
admet-280	239	34	for	for	ADP
admet-280	239	35	scdhs	scdhs	ADJ
admet-280	239	36	,	,	PUNCT
admet-280	239	37	all	all	DET
admet-280	239	38	metabolites	metabolite	NOUN
admet-280	239	39	were	be	AUX
admet-280	239	40	below	below	ADP
admet-280	239	41	the	the	DET
admet-280	239	42	lower	low	ADJ
admet-280	239	43	limit	limit	NOUN
admet-280	239	44	of	of	ADP
admet-280	239	45	quantitation	quantitation	NOUN
admet-280	239	46	(	(	PUNCT
admet-280	239	47	lloq	lloq	PROPN
admet-280	239	48	)	)	PUNCT
admet-280	239	49	with	with	ADP
admet-280	239	50	the	the	DET
admet-280	239	51	exception	exception	NOUN
admet-280	239	52	of	of	ADP
admet-280	239	53	6	6	NUM
admet-280	239	54	-	-	PUNCT
admet-280	239	55	oh	oh	NUM
admet-280	239	56	-	-	PUNCT
admet-280	239	57	testosterone	testosterone	NOUN
admet-280	239	58	,	,	PUNCT
admet-280	239	59	indicating	indicate	VERB
admet-280	239	60	some	some	DET
admet-280	239	61	measurable	measurable	ADJ
admet-280	239	62	activity	activity	NOUN
admet-280	239	63	of	of	ADP
admet-280	239	64	cyp3a	cyp3a	NOUN
admet-280	239	65	(	(	PUNCT
admet-280	239	66	table	table	NOUN
admet-280	239	67	1	1	NUM
admet-280	239	68	)	)	PUNCT
admet-280	239	69	.	.	PUNCT
admet-280	240	1	6	6	NUM
admet-280	240	2	-	-	PUNCT
admet-280	240	3	oh	oh	NUM
admet-280	240	4	-	-	PUNCT
admet-280	240	5	testosterone	testosterone	NOUN
admet-280	240	6	was	be	AUX
admet-280	240	7	detectable	detectable	ADJ
admet-280	240	8	for	for	ADP
admet-280	240	9	both	both	CCONJ
admet-280	240	10	h1	h1	NOUN
admet-280	240	11	and	and	CCONJ
admet-280	240	12	h9	h9	NOUN
admet-280	240	13	scdhs	scdhs	PROPN
admet-280	240	14	,	,	PUNCT
admet-280	240	15	with	with	ADP
admet-280	240	16	activity	activity	NOUN
admet-280	240	17	at	at	ADP
admet-280	240	18	1.27	1.27	NUM
admet-280	240	19	pmol	pmol	NOUN
admet-280	240	20	/	/	SYM
admet-280	240	21	min/106	min/106	NOUN
admet-280	240	22	cells	cell	NOUN
admet-280	240	23	.	.	PUNCT
admet-280	241	1	in	in	ADP
admet-280	241	2	contrast	contrast	NOUN
admet-280	241	3	,	,	PUNCT
admet-280	241	4	activity	activity	NOUN
admet-280	241	5	in	in	ADP
admet-280	241	6	primary	primary	ADJ
admet-280	241	7	hepatocytes	hepatocyte	NOUN
admet-280	241	8	was	be	AUX
admet-280	241	9	92.9	92.9	NUM
admet-280	241	10	pmol	pmol	NOUN
admet-280	241	11	/	/	SYM
admet-280	241	12	min/106	min/106	NOUN
admet-280	241	13	cells	cell	NOUN
admet-280	241	14	.	.	PUNCT
admet-280	242	1	the	the	DET
admet-280	242	2	lloq	lloq	NOUN
admet-280	242	3	for	for	ADP
admet-280	242	4	6	6	NUM
admet-280	242	5	-	-	PUNCT
admet-280	242	6	oh	oh	NUM
admet-280	242	7	-	-	PUNCT
admet-280	242	8	testosterone	testosterone	NOUN
admet-280	242	9	was	be	AUX
admet-280	242	10	0.312	0.312	NUM
admet-280	242	11	μm	μm	NOUN
admet-280	242	12	.	.	PUNCT
admet-280	243	1	positive	positive	ADJ
admet-280	243	2	control	control	NOUN
admet-280	243	3	primary	primary	NOUN
admet-280	243	4	and	and	CCONJ
admet-280	243	5	cryopreserved	cryopreserved	ADJ
admet-280	243	6	hepatocytes	hepatocyte	NOUN
admet-280	243	7	generated	generate	VERB
admet-280	243	8	measurable	measurable	ADJ
admet-280	243	9	metabolites	metabolite	NOUN
admet-280	243	10	for	for	ADP
admet-280	243	11	all	all	DET
admet-280	243	12	compounds	compound	NOUN
admet-280	243	13	tested	test	VERB
admet-280	243	14	,	,	PUNCT
admet-280	243	15	indicating	indicate	VERB
admet-280	243	16	the	the	DET
admet-280	243	17	incubation	incubation	NOUN
admet-280	243	18	assay	assay	NOUN
admet-280	243	19	and	and	CCONJ
admet-280	243	20	lc	lc	PROPN
admet-280	243	21	-	-	PUNCT
admet-280	243	22	ms	ms	PROPN
admet-280	243	23	/	/	SYM
admet-280	243	24	ms	ms	PROPN
admet-280	243	25	method	method	NOUN
admet-280	243	26	was	be	AUX
admet-280	243	27	working	work	VERB
admet-280	243	28	.	.	PUNCT
admet-280	244	1	based	base	VERB
admet-280	244	2	on	on	ADP
admet-280	244	3	the	the	DET
admet-280	244	4	cyp	cyp	ADJ
admet-280	244	5	cocktail	cocktail	NOUN
admet-280	244	6	assay	assay	NOUN
admet-280	244	7	,	,	PUNCT
admet-280	244	8	scdhs	scdhs	ADV
admet-280	244	9	do	do	AUX
admet-280	244	10	not	not	PART
admet-280	244	11	display	display	VERB
admet-280	244	12	detectable	detectable	ADJ
admet-280	244	13	cyp	cyp	ADJ
admet-280	244	14	activity	activity	NOUN
admet-280	244	15	,	,	PUNCT
admet-280	244	16	except	except	SCONJ
admet-280	244	17	for	for	ADP
admet-280	244	18	cyp3a	cyp3a	NOUN
admet-280	244	19	,	,	PUNCT
admet-280	244	20	which	which	PRON
admet-280	244	21	was	be	AUX
admet-280	244	22	expected	expect	VERB
admet-280	244	23	based	base	VERB
admet-280	244	24	on	on	ADP
admet-280	244	25	gene	gene	NOUN
admet-280	244	26	expression	expression	NOUN
admet-280	244	27	profiling	profiling	NOUN
admet-280	244	28	.	.	PUNCT
admet-280	245	1	overall	overall	ADJ
admet-280	245	2	,	,	PUNCT
admet-280	245	3	these	these	DET
admet-280	245	4	results	result	NOUN
admet-280	245	5	demonstrate	demonstrate	VERB
admet-280	245	6	an	an	DET
admet-280	245	7	absence	absence	NOUN
admet-280	245	8	of	of	ADP
admet-280	245	9	functional	functional	ADJ
admet-280	245	10	drug	drug	NOUN
admet-280	245	11	-	-	PUNCT
admet-280	245	12	metabolizing	metabolize	VERB
admet-280	245	13	enzyme	enzyme	NOUN
admet-280	245	14	activity	activity	NOUN
admet-280	245	15	in	in	ADP
admet-280	245	16	scdhs	scdhs	ADJ
admet-280	245	17	,	,	PUNCT
admet-280	245	18	corroborating	corroborate	VERB
admet-280	245	19	what	what	PRON
admet-280	245	20	has	have	AUX
admet-280	245	21	largely	largely	ADV
admet-280	245	22	been	be	AUX
admet-280	245	23	reported	report	VERB
admet-280	245	24	for	for	ADP
admet-280	245	25	scdhs	scdhs	ADJ
admet-280	245	26	to	to	ADP
admet-280	245	27	date	date	NOUN
admet-280	245	28	;	;	PUNCT
admet-280	245	29	that	that	SCONJ
admet-280	245	30	they	they	PRON
admet-280	245	31	are	be	AUX
admet-280	245	32	immature	immature	ADJ
admet-280	245	33	compared	compare	VERB
admet-280	245	34	to	to	ADP
admet-280	245	35	cryopreserved	cryopreserved	ADJ
admet-280	245	36	hepatocytes	hepatocyte	NOUN
admet-280	245	37	,	,	PUNCT
admet-280	245	38	especially	especially	ADV
admet-280	245	39	with	with	ADP
admet-280	245	40	regards	regard	NOUN
admet-280	245	41	to	to	ADP
admet-280	245	42	drug	drug	NOUN
admet-280	245	43	-	-	PUNCT
admet-280	245	44	metabolizing	metabolize	VERB
admet-280	245	45	enzyme	enzyme	NOUN
admet-280	245	46	functions	function	NOUN
admet-280	245	47	.	.	PUNCT
admet-280	246	1	genotyping	genotype	VERB
admet-280	246	2	we	we	PRON
admet-280	246	3	focused	focus	VERB
admet-280	246	4	on	on	ADP
admet-280	246	5	cyp2d6	cyp2d6	NOUN
admet-280	246	6	in	in	ADP
admet-280	246	7	our	our	PRON
admet-280	246	8	analysis	analysis	NOUN
admet-280	246	9	in	in	ADP
admet-280	246	10	utilizing	utilize	VERB
admet-280	246	11	scdhs	scdhs	ADV
admet-280	246	12	for	for	ADP
admet-280	246	13	genotype	genotype	NOUN
admet-280	246	14	-	-	PUNCT
admet-280	246	15	phenotype	phenotype	NOUN
admet-280	246	16	predictions	prediction	NOUN
admet-280	246	17	,	,	PUNCT
admet-280	246	18	given	give	VERB
admet-280	246	19	its	its	PRON
admet-280	246	20	highly	highly	ADV
admet-280	246	21	polymorphic	polymorphic	ADJ
admet-280	246	22	nature	nature	NOUN
admet-280	246	23	and	and	CCONJ
admet-280	246	24	role	role	NOUN
admet-280	246	25	in	in	ADP
admet-280	246	26	metabolizing	metabolize	VERB
admet-280	246	27	about	about	ADV
admet-280	246	28	20	20	NUM
admet-280	246	29	%	%	NOUN
admet-280	246	30	of	of	ADP
admet-280	246	31	marketed	market	VERB
admet-280	246	32	drugs	drug	NOUN
admet-280	246	33	[	[	X
admet-280	246	34	9	9	NUM
admet-280	246	35	,	,	PUNCT
admet-280	246	36	10	10	NUM
admet-280	246	37	]	]	PUNCT
admet-280	246	38	.	.	PUNCT
admet-280	247	1	cyp2d6	cyp2d6	NOUN
admet-280	247	2	is	be	AUX
admet-280	247	3	the	the	DET
admet-280	247	4	most	most	ADV
admet-280	247	5	polymorphic	polymorphic	ADJ
admet-280	247	6	drug	drug	NOUN
admet-280	247	7	-	-	PUNCT
admet-280	247	8	metabolizing	metabolize	VERB
admet-280	247	9	enzyme	enzyme	NOUN
admet-280	247	10	,	,	PUNCT
admet-280	247	11	with	with	ADP
admet-280	247	12	more	more	ADJ
admet-280	247	13	than	than	ADP
admet-280	247	14	63	63	NUM
admet-280	247	15	functional	functional	ADJ
admet-280	247	16	gene	gene	NOUN
admet-280	247	17	alleles	allele	NOUN
admet-280	247	18	admet	admet	PROPN
admet-280	247	19	&	&	CCONJ
admet-280	247	20	dmpk	dmpk	PROPN
admet-280	247	21	4(2	4(2	NUM
admet-280	247	22	)	)	PUNCT
admet-280	247	23	(	(	PUNCT
admet-280	247	24	2016	2016	NUM
admet-280	247	25	)	)	PUNCT
admet-280	247	26	62	62	NUM
admet-280	247	27	-	-	SYM
admet-280	247	28	83	83	NUM
admet-280	247	29	pharmacogenetics	pharmacogenetic	NOUN
admet-280	247	30	and	and	CCONJ
admet-280	247	31	cyp	cyp	ADJ
admet-280	247	32	activity	activity	NOUN
admet-280	247	33	doi	doi	NOUN
admet-280	247	34	:	:	PUNCT
admet-280	247	35	10.5599	10.5599	NUM
admet-280	247	36	/	/	SYM
admet-280	247	37	admet.4.2.280	admet.4.2.280	VERB
admet-280	247	38	73	73	NUM
admet-280	247	39	(	(	PUNCT
admet-280	247	40	www.cypalleles.ki.se/cyp2d6.htm	www.cypalleles.ki.se/cyp2d6.htm	PROPN
admet-280	247	41	)	)	PUNCT
admet-280	247	42	,	,	PUNCT
admet-280	247	43	including	include	VERB
admet-280	247	44	polymorphisms	polymorphism	NOUN
admet-280	247	45	that	that	PRON
admet-280	247	46	result	result	VERB
admet-280	247	47	in	in	ADP
admet-280	247	48	gene	gene	NOUN
admet-280	247	49	deletion	deletion	NOUN
admet-280	247	50	,	,	PUNCT
admet-280	247	51	defective	defective	ADJ
admet-280	247	52	splicing	splicing	NOUN
admet-280	247	53	and	and	CCONJ
admet-280	247	54	gene	gene	NOUN
admet-280	247	55	duplication	duplication	NOUN
admet-280	247	56	.	.	PUNCT
admet-280	248	1	having	have	VERB
admet-280	248	2	an	an	DET
admet-280	248	3	in	in	ADP
admet-280	248	4	vitro	vitro	X
admet-280	248	5	cell	cell	NOUN
admet-280	248	6	system	system	NOUN
admet-280	248	7	,	,	PUNCT
admet-280	248	8	such	such	ADJ
admet-280	248	9	as	as	ADP
admet-280	248	10	genotyped	genotype	VERB
admet-280	248	11	scdhs	scdhs	NOUN
admet-280	248	12	,	,	PUNCT
admet-280	248	13	would	would	AUX
admet-280	248	14	allow	allow	VERB
admet-280	248	15	for	for	ADP
admet-280	248	16	more	more	ADV
admet-280	248	17	thorough	thorough	ADJ
admet-280	248	18	characterization	characterization	NOUN
admet-280	248	19	of	of	ADP
admet-280	248	20	pharmacogenetic	pharmacogenetic	ADJ
admet-280	248	21	effects	effect	NOUN
admet-280	248	22	on	on	ADP
admet-280	248	23	drug	drug	NOUN
admet-280	248	24	metabolism	metabolism	NOUN
admet-280	248	25	,	,	PUNCT
admet-280	248	26	and	and	CCONJ
admet-280	248	27	potentially	potentially	ADV
admet-280	248	28	their	their	PRON
admet-280	248	29	impact	impact	NOUN
admet-280	248	30	on	on	ADP
admet-280	248	31	the	the	DET
admet-280	248	32	pharmacokinetics	pharmacokinetic	NOUN
admet-280	248	33	of	of	ADP
admet-280	248	34	a	a	DET
admet-280	248	35	new	new	ADJ
admet-280	248	36	chemical	chemical	NOUN
admet-280	248	37	entity	entity	NOUN
admet-280	248	38	early	early	ADV
admet-280	248	39	on	on	ADV
admet-280	248	40	in	in	ADP
admet-280	248	41	drug	drug	NOUN
admet-280	248	42	development	development	NOUN
admet-280	248	43	.	.	PUNCT
admet-280	249	1	in	in	ADP
admet-280	249	2	particular	particular	ADJ
admet-280	249	3	,	,	PUNCT
admet-280	249	4	for	for	ADP
admet-280	249	5	compounds	compound	NOUN
admet-280	249	6	found	find	VERB
admet-280	249	7	to	to	PART
admet-280	249	8	be	be	AUX
admet-280	249	9	highly	highly	ADV
admet-280	249	10	metabolized	metabolize	VERB
admet-280	249	11	by	by	ADP
admet-280	249	12	cyp2d6	cyp2d6	NOUN
admet-280	249	13	,	,	PUNCT
admet-280	249	14	where	where	SCONJ
admet-280	249	15	polymorphisms	polymorphism	NOUN
admet-280	249	16	may	may	AUX
admet-280	249	17	lead	lead	VERB
admet-280	249	18	to	to	ADP
admet-280	249	19	therapeutic	therapeutic	ADJ
admet-280	249	20	failure	failure	NOUN
admet-280	249	21	or	or	CCONJ
admet-280	249	22	a	a	DET
admet-280	249	23	drug	drug	NOUN
admet-280	249	24	toxicity	toxicity	NOUN
admet-280	249	25	risk	risk	NOUN
admet-280	249	26	,	,	PUNCT
admet-280	249	27	this	this	PRON
admet-280	249	28	may	may	AUX
admet-280	249	29	aid	aid	VERB
admet-280	249	30	in	in	ADP
admet-280	249	31	making	make	VERB
admet-280	249	32	go	go	VERB
admet-280	249	33	/	/	SYM
admet-280	249	34	no	no	DET
admet-280	249	35	-	-	PUNCT
admet-280	249	36	go	go	NOUN
admet-280	249	37	decisions	decision	NOUN
admet-280	249	38	or	or	CCONJ
admet-280	249	39	help	help	VERB
admet-280	249	40	to	to	PART
admet-280	249	41	inform	inform	VERB
admet-280	249	42	possible	possible	ADJ
admet-280	249	43	inclusion	inclusion	NOUN
admet-280	249	44	of	of	ADP
admet-280	249	45	genotyping	genotyping	NOUN
admet-280	249	46	/	/	SYM
admet-280	249	47	phenotyping	phenotyping	NOUN
admet-280	249	48	of	of	ADP
admet-280	249	49	patients	patient	NOUN
admet-280	249	50	in	in	ADP
admet-280	249	51	clinical	clinical	ADJ
admet-280	249	52	studies	study	NOUN
admet-280	249	53	.	.	PUNCT
admet-280	250	1	select	select	ADJ
admet-280	250	2	genotyping	genotyping	NOUN
admet-280	250	3	results	result	NOUN
admet-280	250	4	for	for	ADP
admet-280	250	5	cyp2d6	cyp2d6	NOUN
admet-280	250	6	can	can	AUX
admet-280	250	7	be	be	AUX
admet-280	250	8	found	find	VERB
admet-280	250	9	in	in	ADP
admet-280	250	10	table	table	NOUN
admet-280	250	11	2	2	NUM
admet-280	250	12	.	.	PUNCT
admet-280	250	13	analysis	analysis	NOUN
admet-280	250	14	of	of	ADP
admet-280	250	15	cyp2d6	cyp2d6	NOUN
admet-280	250	16	copy	copy	NOUN
admet-280	250	17	number	number	NOUN
admet-280	250	18	found	find	VERB
admet-280	250	19	h1	h1	PROPN
admet-280	250	20	to	to	PART
admet-280	250	21	have	have	VERB
admet-280	250	22	1	1	NUM
admet-280	250	23	copy	copy	NOUN
admet-280	250	24	,	,	PUNCT
admet-280	250	25	with	with	ADP
admet-280	250	26	all	all	DET
admet-280	250	27	other	other	ADJ
admet-280	250	28	lines	line	NOUN
admet-280	250	29	having	have	VERB
admet-280	250	30	2	2	NUM
admet-280	250	31	copies	copy	NOUN
admet-280	250	32	of	of	ADP
admet-280	250	33	cyp2d6	cyp2d6	NOUN
admet-280	250	34	.	.	PUNCT
admet-280	251	1	no	no	DET
admet-280	251	2	cyp2d6	cyp2d6	NOUN
admet-280	251	3	duplications	duplication	NOUN
admet-280	251	4	were	be	AUX
admet-280	251	5	found	find	VERB
admet-280	251	6	,	,	PUNCT
admet-280	251	7	indicating	indicate	VERB
admet-280	251	8	there	there	PRON
admet-280	251	9	is	be	VERB
admet-280	251	10	no	no	DET
admet-280	251	11	representative	representative	NOUN
admet-280	251	12	of	of	ADP
admet-280	251	13	a	a	DET
admet-280	251	14	cyp2d6	cyp2d6	NOUN
admet-280	251	15	ultra	ultra	ADJ
admet-280	251	16	-	-	ADJ
admet-280	251	17	rapid	rapid	ADJ
admet-280	251	18	metabolizer	metabolizer	NOUN
admet-280	251	19	within	within	ADP
admet-280	251	20	these	these	DET
admet-280	251	21	cell	cell	NOUN
admet-280	251	22	lines	line	NOUN
admet-280	251	23	(	(	PUNCT
admet-280	251	24	table	table	NOUN
admet-280	251	25	2	2	NUM
admet-280	251	26	)	)	PUNCT
admet-280	251	27	.	.	PUNCT
admet-280	252	1	table	table	NOUN
admet-280	253	1	1	1	NUM
admet-280	253	2	.	.	PUNCT
admet-280	253	3	cyp	cyp	ADJ
admet-280	253	4	cocktail	cocktail	NOUN
admet-280	253	5	assay	assay	NOUN
admet-280	253	6	results	result	NOUN
admet-280	253	7	.	.	PUNCT
admet-280	254	1	results	result	NOUN
admet-280	254	2	are	be	AUX
admet-280	254	3	reported	report	VERB
admet-280	254	4	as	as	ADP
admet-280	254	5	mean	mean	NOUN
admet-280	254	6	(	(	PUNCT
admet-280	254	7	sd	sd	NOUN
admet-280	254	8	)	)	PUNCT
admet-280	254	9	.	.	PUNCT
admet-280	255	1	scdh	scdh	NOUN
admet-280	255	2	activity	activity	NOUN
admet-280	255	3	,	,	PUNCT
admet-280	255	4	n	n	NOUN
admet-280	255	5	=	=	SYM
admet-280	255	6	6	6	NUM
admet-280	255	7	;	;	PUNCT
admet-280	255	8	primary	primary	ADJ
admet-280	255	9	hepatocyte	hepatocyte	NOUN
admet-280	255	10	activity	activity	NOUN
admet-280	255	11	,	,	PUNCT
admet-280	255	12	n	n	NOUN
admet-280	255	13	=	=	SYM
admet-280	255	14	2	2	X
admet-280	255	15	.	.	PUNCT
admet-280	256	1	lloq	lloq	NOUN
admet-280	256	2	=	=	PUNCT
admet-280	256	3	lower	low	ADJ
admet-280	256	4	limit	limit	NOUN
admet-280	256	5	of	of	ADP
admet-280	256	6	quantitation	quantitation	NOUN
admet-280	256	7	lloq	lloq	NOUN
admet-280	256	8	(	(	PUNCT
admet-280	256	9	μm	μm	NOUN
admet-280	256	10	)	)	PUNCT
admet-280	256	11	scdh	scdh	NOUN
admet-280	256	12	activity	activity	NOUN
admet-280	256	13	(	(	PUNCT
admet-280	256	14	pmol	pmol	NOUN
admet-280	256	15	/	/	SYM
admet-280	256	16	min/10	min/10	ADJ
admet-280	256	17	6	6	NUM
admet-280	256	18	cells	cell	NOUN
admet-280	256	19	)	)	PUNCT
admet-280	256	20	primary	primary	ADJ
admet-280	256	21	hepatocyte	hepatocyte	NOUN
admet-280	256	22	activity	activity	NOUN
admet-280	256	23	(	(	PUNCT
admet-280	256	24	pmol	pmol	NOUN
admet-280	256	25	/	/	SYM
admet-280	256	26	min/10	min/10	ADJ
admet-280	256	27	6	6	NUM
admet-280	256	28	cells	cell	NOUN
admet-280	256	29	)	)	PUNCT
admet-280	256	30	cyp3a	cyp3a	VERB
admet-280	256	31	0.312	0.312	NUM
admet-280	256	32	1.27	1.27	NUM
admet-280	256	33	(	(	PUNCT
admet-280	256	34	0.361	0.361	NUM
admet-280	256	35	)	)	PUNCT
admet-280	256	36	92.9	92.9	NUM
admet-280	256	37	(	(	PUNCT
admet-280	256	38	1.45	1.45	NUM
admet-280	256	39	)	)	PUNCT
admet-280	256	40	cyp1a	cyp1a	NOUN
admet-280	257	1	0.125	0.125	NUM
admet-280	257	2	blq	blq	PROPN
admet-280	257	3	14.9	14.9	NUM
admet-280	257	4	(	(	PUNCT
admet-280	257	5	0.365	0.365	NUM
admet-280	257	6	)	)	PUNCT
admet-280	258	1	cyp2a6	cyp2a6	NOUN
admet-280	258	2	0.0084	0.0084	NUM
admet-280	258	3	blq	blq	PROPN
admet-280	258	4	0.0431	0.0431	NUM
admet-280	258	5	(	(	PUNCT
admet-280	258	6	0.0168	0.0168	NUM
admet-280	258	7	)	)	PUNCT
admet-280	258	8	cyp2b6	cyp2b6	NOUN
admet-280	258	9	0.0039	0.0039	NUM
admet-280	258	10	blq	blq	PROPN
admet-280	258	11	1.62	1.62	NUM
admet-280	258	12	(	(	PUNCT
admet-280	258	13	0.169	0.169	NUM
admet-280	258	14	)	)	PUNCT
admet-280	258	15	cyp2c8	cyp2c8	ADV
admet-280	258	16	0.017	0.017	NUM
admet-280	258	17	blq	blq	PROPN
admet-280	258	18	0.917	0.917	NUM
admet-280	258	19	(	(	PUNCT
admet-280	258	20	0.066	0.066	NUM
admet-280	258	21	)	)	PUNCT
admet-280	258	22	cyp2c9	cyp2c9	NOUN
admet-280	258	23	0.013	0.013	NUM
admet-280	258	24	blq	blq	PROPN
admet-280	258	25	2.85	2.85	NUM
admet-280	258	26	(	(	PUNCT
admet-280	258	27	0.00544	0.00544	NUM
admet-280	258	28	)	)	PUNCT
admet-280	258	29	cyp2d6	cyp2d6	NOUN
admet-280	258	30	0.0017	0.0017	NUM
admet-280	258	31	blq	blq	PROPN
admet-280	258	32	2.27	2.27	NUM
admet-280	258	33	(	(	PUNCT
admet-280	258	34	0.122	0.122	NUM
admet-280	258	35	)	)	PUNCT
admet-280	258	36	cyp2e1	cyp2e1	ADJ
admet-280	258	37	1	1	NUM
admet-280	258	38	blq	blq	ADP
admet-280	258	39	12.1	12.1	NUM
admet-280	258	40	(	(	PUNCT
admet-280	258	41	0.695	0.695	NUM
admet-280	258	42	)	)	PUNCT
admet-280	258	43	table	table	NOUN
admet-280	258	44	2	2	NUM
admet-280	258	45	.	.	PUNCT
admet-280	259	1	cyp2d6	cyp2d6	NOUN
admet-280	259	2	genotyping	genotyping	NOUN
admet-280	259	3	results	result	NOUN
admet-280	259	4	.	.	PUNCT
admet-280	260	1	a	a	DET
admet-280	260	2	summary	summary	NOUN
admet-280	260	3	of	of	ADP
admet-280	260	4	the	the	DET
admet-280	260	5	cyp2d6	cyp2d6	NOUN
admet-280	260	6	copy	copy	NOUN
admet-280	260	7	number	number	NOUN
admet-280	260	8	and	and	CCONJ
admet-280	260	9	genotyping	genotyping	NOUN
admet-280	260	10	results	result	NOUN
admet-280	260	11	for	for	ADP
admet-280	260	12	wicell	wicell	PROPN
admet-280	260	13	®	®	PROPN
admet-280	260	14	hesc	hesc	PROPN
admet-280	260	15	lines	lines	PROPN
admet-280	260	16	h1	h1	PROPN
admet-280	260	17	,	,	PUNCT
admet-280	260	18	h7	h7	PROPN
admet-280	260	19	,	,	PUNCT
admet-280	260	20	h9	h9	NOUN
admet-280	260	21	,	,	PUNCT
admet-280	260	22	h13	h13	NOUN
admet-280	260	23	,	,	PUNCT
admet-280	260	24	and	and	CCONJ
admet-280	260	25	h14	h14	NOUN
admet-280	260	26	.	.	PUNCT
admet-280	261	1	based	base	VERB
admet-280	261	2	on	on	ADP
admet-280	261	3	genotyping	genotyping	NOUN
admet-280	261	4	results	result	VERB
admet-280	261	5	a	a	DET
admet-280	261	6	prediction	prediction	NOUN
admet-280	261	7	for	for	SCONJ
admet-280	261	8	expected	expect	VERB
admet-280	261	9	cyp2d6	cyp2d6	NOUN
admet-280	261	10	phenotype	phenotype	NOUN
admet-280	261	11	of	of	ADP
admet-280	261	12	each	each	DET
admet-280	261	13	cell	cell	NOUN
admet-280	261	14	line	line	NOUN
admet-280	261	15	was	be	AUX
admet-280	261	16	made	make	VERB
admet-280	261	17	.	.	PUNCT
admet-280	262	1	pm	pm	NOUN
admet-280	262	2	=	=	PUNCT
admet-280	262	3	poor	poor	ADJ
admet-280	262	4	metabolizer	metabolizer	NOUN
admet-280	262	5	,	,	PUNCT
admet-280	262	6	i	i	PRON
admet-280	262	7	m	m	VERB
admet-280	262	8	=	=	VERB
admet-280	262	9	intermediate	intermediate	ADJ
admet-280	262	10	metabolizer	metabolizer	NOUN
admet-280	262	11	,	,	PUNCT
admet-280	262	12	em	em	PRON
admet-280	262	13	=	=	NUM
admet-280	262	14	extensive	extensive	ADJ
admet-280	262	15	metabolizer	metabolizer	NOUN
admet-280	262	16	.	.	PUNCT
admet-280	263	1	common	common	ADJ
admet-280	263	2	name	name	NOUN
admet-280	263	3	probe	probe	NOUN
admet-280	263	4	set	set	VERB
admet-280	263	5	i	i	PRON
admet-280	263	6	d	d	PROPN
admet-280	263	7	h1	h1	PROPN
admet-280	263	8	h7	h7	PROPN
admet-280	263	9	h9	h9	PROPN
admet-280	263	10	h13	h13	PROPN
admet-280	263	11	h14	h14	NOUN
admet-280	263	12	copy	copy	NOUN
admet-280	263	13	number	number	NOUN
admet-280	263	14	1	1	NUM
admet-280	263	15	2	2	NUM
admet-280	263	16	2	2	NUM
admet-280	263	17	2	2	NUM
admet-280	263	18	2	2	NUM
admet-280	263	19	cyp2d6	cyp2d6	NOUN
admet-280	263	20	*	*	SYM
admet-280	263	21	2	2	NUM
admet-280	263	22	2850c	2850c	NUM
admet-280	263	23	>	>	X
admet-280	263	24	t	t	PROPN
admet-280	263	25	am_12261	am_12261	PROPN
admet-280	263	26	t	t	PROPN
admet-280	263	27	c	c	PROPN
admet-280	263	28	/	/	SYM
admet-280	263	29	t	t	PROPN
admet-280	263	30	c	c	PROPN
admet-280	263	31	/	/	SYM
admet-280	263	32	t	t	PROPN
admet-280	263	33	t	t	PROPN
admet-280	263	34	/	/	SYM
admet-280	263	35	t	t	PROPN
admet-280	263	36	c	c	PROPN
admet-280	263	37	/	/	SYM
admet-280	263	38	t	t	PROPN
admet-280	263	39	cyp2d6	cyp2d6	NOUN
admet-280	263	40	*	*	SYM
admet-280	263	41	3	3	NUM
admet-280	263	42	2549dela	2549dela	NUM
admet-280	263	43	am_12267	am_12267	ADP
admet-280	263	44	a	a	DET
admet-280	263	45	a	a	NOUN
admet-280	263	46	/	/	SYM
admet-280	263	47	a	a	DET
admet-280	263	48	a	a	NOUN
admet-280	263	49	/	/	SYM
admet-280	263	50	a	a	DET
admet-280	263	51	a	a	NOUN
admet-280	263	52	/	/	SYM
admet-280	263	53	a	a	DET
admet-280	263	54	a	a	NOUN
admet-280	263	55	/	/	SYM
admet-280	263	56	a	a	DET
admet-280	263	57	cyp2d6	cyp2d6	NOUN
admet-280	263	58	*	*	SYM
admet-280	263	59	4	4	NUM
admet-280	263	60	1846g	1846g	NUM
admet-280	263	61	>	>	X
admet-280	263	62	a	a	DET
admet-280	263	63	am_12274	am_12274	NOUN
admet-280	263	64	g	g	NOUN
admet-280	263	65	g	g	NOUN
admet-280	263	66	/	/	SYM
admet-280	263	67	a	a	DET
admet-280	263	68	g	g	NOUN
admet-280	263	69	/	/	SYM
admet-280	263	70	g	g	NOUN
admet-280	263	71	g	g	NOUN
admet-280	263	72	/	/	SYM
admet-280	263	73	g	g	NOUN
admet-280	263	74	g	g	NOUN
admet-280	263	75	/	/	SYM
admet-280	263	76	a	a	DET
admet-280	263	77	cyp2d6	cyp2d6	NOUN
admet-280	263	78	*	*	SYM
admet-280	263	79	6	6	NUM
admet-280	263	80	1707delt	1707delt	NUM
admet-280	263	81	am_12276	am_12276	PROPN
admet-280	263	82	t	t	PROPN
admet-280	263	83	t	t	PROPN
admet-280	263	84	/	/	SYM
admet-280	263	85	t	t	PROPN
admet-280	264	1	t	t	PROPN
admet-280	264	2	/	/	SYM
admet-280	264	3	t	t	PROPN
admet-280	264	4	t	t	PROPN
admet-280	264	5	/	/	SYM
admet-280	264	6	t	t	PROPN
admet-280	264	7	t	t	PROPN
admet-280	264	8	/	/	SYM
admet-280	264	9	t	t	PROPN
admet-280	264	10	cyp2d6	cyp2d6	NOUN
admet-280	264	11	*	*	SYM
admet-280	264	12	9	9	NUM
admet-280	264	13	2613_2615delaga	2613_2615delaga	NOUN
admet-280	264	14	am_12264	am_12264	PROPN
admet-280	264	15	aga	aga	PROPN
admet-280	264	16	aga	aga	PROPN
admet-280	264	17	/	/	SYM
admet-280	264	18	aga	aga	PROPN
admet-280	264	19	aga	aga	PROPN
admet-280	264	20	/	/	SYM
admet-280	264	21	aga	aga	PROPN
admet-280	264	22	aga	aga	PROPN
admet-280	264	23	/	/	SYM
admet-280	264	24	aga	aga	PROPN
admet-280	264	25	aga	aga	PROPN
admet-280	264	26	/	/	SYM
admet-280	264	27	aga	aga	PROPN
admet-280	264	28	cyp2d6	cyp2d6	NOUN
admet-280	264	29	*	*	PROPN
admet-280	264	30	10	10	NUM
admet-280	264	31	100c	100c	PROPN
admet-280	264	32	>	>	X
admet-280	264	33	t	t	PROPN
admet-280	264	34	am_12285	am_12285	PROPN
admet-280	264	35	c	c	PROPN
admet-280	264	36	c	c	X
admet-280	264	37	/	/	SYM
admet-280	264	38	t	t	PROPN
admet-280	264	39	c	c	PROPN
admet-280	264	40	/	/	SYM
admet-280	264	41	t	t	PROPN
admet-280	264	42	c	c	X
admet-280	264	43	/	/	SYM
admet-280	264	44	c	c	NOUN
admet-280	264	45	c	c	PROPN
admet-280	264	46	/	/	SYM
admet-280	264	47	t	t	PROPN
admet-280	264	48	cyp2d6	cyp2d6	NOUN
admet-280	264	49	*	*	PROPN
admet-280	264	50	17	17	NUM
admet-280	264	51	1023c	1023c	NOUN
admet-280	264	52	>	>	SYM
admet-280	264	53	t	t	PROPN
admet-280	264	54	am_12280	am_12280	PROPN
admet-280	264	55	c	c	PROPN
admet-280	264	56	c	c	X
admet-280	264	57	/	/	SYM
admet-280	264	58	c	c	NOUN
admet-280	264	59	c	c	X
admet-280	264	60	/	/	SYM
admet-280	264	61	c	c	NOUN
admet-280	264	62	c	c	X
admet-280	264	63	/	/	SYM
admet-280	264	64	c	c	NOUN
admet-280	264	65	c	c	NOUN
admet-280	264	66	/	/	SYM
admet-280	264	67	c	c	NOUN
admet-280	264	68	cyp2d6	cyp2d6	NOUN
admet-280	264	69	*	*	PROPN
admet-280	264	70	29	29	NUM
admet-280	264	71	3183g	3183g	NUM
admet-280	264	72	>	>	X
admet-280	264	73	a	a	DET
admet-280	264	74	am_12255	am_12255	PROPN
admet-280	264	75	g	g	NOUN
admet-280	264	76	g	g	NOUN
admet-280	264	77	/	/	SYM
admet-280	264	78	g	g	NOUN
admet-280	264	79	g	g	NOUN
admet-280	264	80	/	/	SYM
admet-280	264	81	g	g	NOUN
admet-280	264	82	g	g	NOUN
admet-280	264	83	/	/	SYM
admet-280	264	84	g	g	NOUN
admet-280	264	85	g	g	NOUN
admet-280	264	86	/	/	SYM
admet-280	264	87	g	g	NOUN
admet-280	264	88	cyp2d6	cyp2d6	NOUN
admet-280	264	89	*	*	SYM
admet-280	264	90	35	35	NUM
admet-280	264	91	4180g	4180g	NOUN
admet-280	264	92	>	>	PUNCT
admet-280	264	93	c	c	X
admet-280	264	94	am_12247	am_12247	PROPN
admet-280	264	95	c	c	NOUN
admet-280	264	96	c	c	X
admet-280	264	97	/	/	SYM
admet-280	264	98	c	c	NOUN
admet-280	264	99	c	c	X
admet-280	264	100	/	/	SYM
admet-280	264	101	c	c	NOUN
admet-280	264	102	c	c	X
admet-280	264	103	/	/	SYM
admet-280	264	104	c	c	NOUN
admet-280	264	105	c	c	NOUN
admet-280	264	106	/	/	SYM
admet-280	264	107	c	c	NOUN
admet-280	264	108	cyp2d6	cyp2d6	NOUN
admet-280	264	109	*	*	SYM
admet-280	264	110	41	41	NUM
admet-280	264	111	2988g	2988g	NUM
admet-280	264	112	>	>	PUNCT
admet-280	264	113	a	a	DET
admet-280	264	114	am_12257	am_12257	NOUN
admet-280	264	115	a	a	DET
admet-280	264	116	g	g	NOUN
admet-280	264	117	/	/	SYM
admet-280	264	118	g	g	NOUN
admet-280	264	119	g	g	PROPN
admet-280	264	120	/	/	SYM
admet-280	264	121	a	a	DET
admet-280	264	122	g	g	NOUN
admet-280	264	123	/	/	SYM
admet-280	264	124	g	g	NOUN
admet-280	264	125	g	g	PROPN
admet-280	264	126	/	/	SYM
admet-280	264	127	g	g	PROPN
admet-280	264	128	predicted	predict	VERB
admet-280	264	129	phenotype	phenotype	NOUN
admet-280	264	130	pm	pm	NOUN
admet-280	264	131	-	-	PUNCT
admet-280	264	132	im	im	NOUN
admet-280	265	1	i	i	PRON
admet-280	265	2	m	m	VERB
admet-280	265	3	im	im	NOUN
admet-280	265	4	-	-	ADJ
admet-280	265	5	em	em	PRON
admet-280	265	6	em	em	PRON
admet-280	266	1	i	i	NOUN
admet-280	266	2	m	m	VERB
admet-280	266	3	http://www.cypalleles.ki.se/cyp2d6.htm	http://www.cypalleles.ki.se/cyp2d6.htm	PROPN
admet-280	266	4	voellinger	voellinger	NOUN
admet-280	266	5	and	and	CCONJ
admet-280	266	6	kelly	kelly	PROPN
admet-280	266	7	admet	admet	PROPN
admet-280	266	8	&	&	CCONJ
admet-280	266	9	dmpk	dmpk	PROPN
admet-280	266	10	4(2	4(2	NUM
admet-280	266	11	)	)	PUNCT
admet-280	266	12	(	(	PUNCT
admet-280	266	13	2016	2016	NUM
admet-280	266	14	)	)	PUNCT
admet-280	266	15	62	62	NUM
admet-280	266	16	-	-	SYM
admet-280	266	17	83	83	NUM
admet-280	266	18	74	74	NUM
admet-280	266	19	lines	line	NOUN
admet-280	266	20	h7	h7	PROPN
admet-280	266	21	and	and	CCONJ
admet-280	266	22	h14	h14	NOUN
admet-280	266	23	were	be	AUX
admet-280	266	24	both	both	PRON
admet-280	266	25	found	find	VERB
admet-280	266	26	to	to	PART
admet-280	266	27	have	have	VERB
admet-280	266	28	one	one	NUM
admet-280	266	29	copy	copy	NOUN
admet-280	266	30	of	of	ADP
admet-280	266	31	the	the	DET
admet-280	266	32	cyp2d6	cyp2d6	NOUN
admet-280	266	33	*	*	SYM
admet-280	266	34	4	4	NUM
admet-280	266	35	null	null	ADJ
admet-280	266	36	allele	allele	NOUN
admet-280	266	37	,	,	PUNCT
admet-280	266	38	with	with	ADP
admet-280	266	39	no	no	DET
admet-280	266	40	other	other	ADJ
admet-280	266	41	polymorphisms	polymorphism	NOUN
admet-280	266	42	associated	associate	VERB
admet-280	266	43	with	with	ADP
admet-280	266	44	aberrant	aberrant	ADJ
admet-280	266	45	function	function	NOUN
admet-280	266	46	detected	detect	VERB
admet-280	266	47	.	.	PUNCT
admet-280	267	1	with	with	ADP
admet-280	267	2	regard	regard	NOUN
admet-280	267	3	to	to	ADP
admet-280	267	4	the	the	DET
admet-280	267	5	cyp2d6	cyp2d6	NOUN
admet-280	267	6	*	*	SYM
admet-280	267	7	41	41	NUM
admet-280	267	8	allele	allele	NOUN
admet-280	267	9	,	,	PUNCT
admet-280	267	10	line	line	NOUN
admet-280	267	11	h9	h9	NOUN
admet-280	267	12	was	be	AUX
admet-280	267	13	found	find	VERB
admet-280	267	14	to	to	PART
admet-280	267	15	be	be	AUX
admet-280	267	16	heterozygous	heterozygous	ADJ
admet-280	267	17	for	for	ADP
admet-280	267	18	this	this	DET
admet-280	267	19	allele	allele	NOUN
admet-280	267	20	,	,	PUNCT
admet-280	267	21	and	and	CCONJ
admet-280	267	22	the	the	DET
admet-280	267	23	single	single	ADJ
admet-280	267	24	gene	gene	NOUN
admet-280	267	25	copy	copy	NOUN
admet-280	267	26	of	of	ADP
admet-280	267	27	cyp2d6	cyp2d6	NOUN
admet-280	267	28	in	in	ADP
admet-280	267	29	line	line	NOUN
admet-280	267	30	h1	h1	PROPN
admet-280	267	31	also	also	ADV
admet-280	267	32	contains	contain	VERB
admet-280	267	33	the	the	DET
admet-280	267	34	cyp2d6	cyp2d6	NOUN
admet-280	267	35	*	*	SYM
admet-280	267	36	41	41	NUM
admet-280	267	37	allele	allele	NOUN
admet-280	267	38	.	.	PUNCT
admet-280	268	1	taking	take	VERB
admet-280	268	2	the	the	DET
admet-280	268	3	copy	copy	NOUN
admet-280	268	4	number	number	NOUN
admet-280	268	5	and	and	CCONJ
admet-280	268	6	genotyping	genotype	VERB
admet-280	268	7	data	datum	NOUN
admet-280	268	8	together	together	ADV
admet-280	268	9	,	,	PUNCT
admet-280	268	10	we	we	PRON
admet-280	268	11	have	have	AUX
admet-280	268	12	made	make	VERB
admet-280	268	13	predictions	prediction	NOUN
admet-280	268	14	regarding	regard	VERB
admet-280	268	15	cyp2d6	cyp2d6	NOUN
admet-280	268	16	phenotype	phenotype	NOUN
admet-280	268	17	in	in	ADP
admet-280	268	18	these	these	DET
admet-280	268	19	cell	cell	NOUN
admet-280	268	20	lines	line	NOUN
admet-280	268	21	,	,	PUNCT
admet-280	268	22	as	as	SCONJ
admet-280	268	23	found	find	VERB
admet-280	268	24	in	in	ADP
admet-280	268	25	table	table	NOUN
admet-280	268	26	2	2	NUM
admet-280	268	27	.	.	PUNCT
admet-280	268	28	to	to	PART
admet-280	268	29	summarize	summarize	VERB
admet-280	268	30	,	,	PUNCT
admet-280	268	31	we	we	PRON
admet-280	268	32	predict	predict	VERB
admet-280	268	33	line	line	NOUN
admet-280	268	34	h1	h1	NOUN
admet-280	268	35	to	to	PART
admet-280	268	36	be	be	AUX
admet-280	268	37	a	a	DET
admet-280	268	38	cyp2d6	cyp2d6	NOUN
admet-280	268	39	poor	poor	ADJ
admet-280	268	40	-	-	PUNCT
admet-280	268	41	intermediate	intermediate	ADJ
admet-280	268	42	metabolizer	metabolizer	NOUN
admet-280	268	43	,	,	PUNCT
admet-280	268	44	lines	line	NOUN
admet-280	268	45	h7	h7	VERB
admet-280	268	46	and	and	CCONJ
admet-280	268	47	h14	h14	NOUN
admet-280	268	48	to	to	PART
admet-280	268	49	be	be	AUX
admet-280	268	50	intermediate	intermediate	ADJ
admet-280	268	51	metabolizers	metabolizer	NOUN
admet-280	268	52	,	,	PUNCT
admet-280	268	53	line	line	NOUN
admet-280	268	54	h9	h9	NOUN
admet-280	268	55	to	to	PART
admet-280	268	56	be	be	AUX
admet-280	268	57	an	an	DET
admet-280	268	58	intermediate	intermediate	ADJ
admet-280	268	59	-	-	PUNCT
admet-280	268	60	extensive	extensive	ADJ
admet-280	268	61	metabolizer	metabolizer	NOUN
admet-280	268	62	,	,	PUNCT
admet-280	268	63	depending	depend	VERB
admet-280	268	64	on	on	ADP
admet-280	268	65	activity	activity	NOUN
admet-280	268	66	from	from	ADP
admet-280	268	67	the	the	DET
admet-280	268	68	cyp2d6	cyp2d6	PROPN
admet-280	268	69	*	*	SYM
admet-280	268	70	41	41	NUM
admet-280	268	71	allele	allele	NOUN
admet-280	268	72	,	,	PUNCT
admet-280	268	73	and	and	CCONJ
admet-280	268	74	line	line	NOUN
admet-280	268	75	h13	h13	NOUN
admet-280	268	76	to	to	PART
admet-280	268	77	be	be	AUX
admet-280	268	78	an	an	DET
admet-280	268	79	extensive	extensive	ADJ
admet-280	268	80	metabolizer	metabolizer	NOUN
admet-280	268	81	.	.	PUNCT
admet-280	269	1	select	select	ADJ
admet-280	269	2	genotyping	genotyping	NOUN
admet-280	269	3	results	result	NOUN
admet-280	269	4	for	for	ADP
admet-280	269	5	other	other	ADJ
admet-280	269	6	cyp	cyp	ADJ
admet-280	269	7	enzymes	enzyme	NOUN
admet-280	269	8	can	can	AUX
admet-280	269	9	be	be	AUX
admet-280	269	10	found	find	VERB
admet-280	269	11	in	in	ADP
admet-280	269	12	table	table	NOUN
admet-280	269	13	3	3	NUM
admet-280	269	14	.	.	PUNCT
admet-280	270	1	notably	notably	ADV
admet-280	270	2	,	,	PUNCT
admet-280	270	3	all	all	PRON
admet-280	270	4	5	5	NUM
admet-280	270	5	hesc	hesc	NOUN
admet-280	270	6	lines	line	NOUN
admet-280	270	7	were	be	AUX
admet-280	270	8	found	find	VERB
admet-280	270	9	to	to	PART
admet-280	270	10	be	be	AUX
admet-280	270	11	homozygous	homozygous	ADJ
admet-280	270	12	for	for	ADP
admet-280	270	13	cyp3a5	cyp3a5	NOUN
admet-280	270	14	*	*	SYM
admet-280	270	15	3	3	NUM
admet-280	270	16	,	,	PUNCT
admet-280	270	17	a	a	DET
admet-280	270	18	null	null	ADJ
admet-280	270	19	allele	allele	NOUN
admet-280	270	20	,	,	PUNCT
admet-280	270	21	meaning	mean	VERB
admet-280	270	22	they	they	PRON
admet-280	270	23	are	be	AUX
admet-280	270	24	all	all	PRON
admet-280	270	25	cyp3a5	cyp3a5	ADJ
admet-280	270	26	non	non	ADJ
admet-280	270	27	-	-	NOUN
admet-280	270	28	expressers	expresser	NOUN
admet-280	270	29	.	.	PUNCT
admet-280	271	1	in	in	ADP
admet-280	271	2	addition	addition	NOUN
admet-280	271	3	,	,	PUNCT
admet-280	271	4	the	the	DET
admet-280	271	5	h14	h14	NOUN
admet-280	271	6	line	line	NOUN
admet-280	271	7	is	be	AUX
admet-280	271	8	homozygous	homozygous	ADJ
admet-280	271	9	for	for	ADP
admet-280	271	10	cyp2c9	cyp2c9	NOUN
admet-280	271	11	*	*	NOUN
admet-280	271	12	2	2	NUM
admet-280	271	13	and	and	CCONJ
admet-280	271	14	h1	h1	NOUN
admet-280	271	15	is	be	AUX
admet-280	271	16	heterozygous	heterozygous	ADJ
admet-280	271	17	for	for	ADP
admet-280	271	18	cyp2c9	cyp2c9	NOUN
admet-280	271	19	*	*	NOUN
admet-280	271	20	3	3	NUM
admet-280	271	21	;	;	PUNCT
admet-280	271	22	both	both	PRON
admet-280	271	23	of	of	ADP
admet-280	271	24	these	these	DET
admet-280	271	25	alleles	allele	NOUN
admet-280	271	26	result	result	VERB
admet-280	271	27	in	in	ADP
admet-280	271	28	decreased	decrease	VERB
admet-280	271	29	cyp2c9	cyp2c9	NOUN
admet-280	271	30	activity	activity	NOUN
admet-280	271	31	and	and	CCONJ
admet-280	271	32	have	have	AUX
admet-280	271	33	documented	document	VERB
admet-280	271	34	effects	effect	NOUN
admet-280	271	35	on	on	ADP
admet-280	271	36	in	in	ADP
admet-280	271	37	vitro	vitro	X
admet-280	271	38	and	and	CCONJ
admet-280	271	39	in	in	ADP
admet-280	271	40	vivo	vivo	ADJ
admet-280	271	41	pharmacokinetics	pharmacokinetic	NOUN
admet-280	271	42	and	and	CCONJ
admet-280	271	43	clinical	clinical	ADJ
admet-280	271	44	drug	drug	NOUN
admet-280	271	45	response	response	NOUN
admet-280	271	46	,	,	PUNCT
admet-280	271	47	e.g.	e.g.	ADV
admet-280	271	48	warfarin	warfarin	NOUN
admet-280	271	49	[	[	X
admet-280	271	50	48	48	NUM
admet-280	271	51	]	]	PUNCT
admet-280	271	52	.	.	PUNCT
admet-280	272	1	genotyping	genotype	VERB
admet-280	272	2	results	result	NOUN
admet-280	272	3	for	for	ADP
admet-280	272	4	phase	phase	NOUN
admet-280	272	5	ii	ii	PROPN
admet-280	272	6	/	/	SYM
admet-280	272	7	iii	iii	NUM
admet-280	272	8	enzymes	enzyme	NOUN
admet-280	272	9	can	can	AUX
admet-280	272	10	be	be	AUX
admet-280	272	11	found	find	VERB
admet-280	272	12	in	in	ADP
admet-280	272	13	table	table	NOUN
admet-280	272	14	4	4	NUM
admet-280	272	15	.	.	PUNCT
admet-280	272	16	lines	lines	PROPN
admet-280	272	17	h7	h7	PROPN
admet-280	272	18	,	,	PUNCT
admet-280	272	19	h13	h13	NOUN
admet-280	272	20	,	,	PUNCT
admet-280	272	21	and	and	CCONJ
admet-280	272	22	h14	h14	NOUN
admet-280	272	23	are	be	AUX
admet-280	272	24	heterozygous	heterozygous	ADJ
admet-280	272	25	for	for	ADP
admet-280	272	26	the	the	DET
admet-280	272	27	ugt1a1	ugt1a1	ADJ
admet-280	272	28	*	*	ADJ
admet-280	272	29	28	28	NUM
admet-280	272	30	allele	allele	NOUN
admet-280	272	31	,	,	PUNCT
admet-280	272	32	which	which	PRON
admet-280	272	33	results	result	VERB
admet-280	272	34	in	in	ADP
admet-280	272	35	reduced	reduced	ADJ
admet-280	272	36	activity	activity	NOUN
admet-280	272	37	of	of	ADP
admet-280	272	38	ugt1a1	ugt1a1	NOUN
admet-280	273	1	[	[	X
admet-280	273	2	49	49	NUM
admet-280	273	3	]	]	PUNCT
admet-280	273	4	.	.	PUNCT
admet-280	274	1	clinically	clinically	ADV
admet-280	274	2	,	,	PUNCT
admet-280	274	3	reduced	reduced	ADJ
admet-280	274	4	activity	activity	NOUN
admet-280	274	5	of	of	ADP
admet-280	274	6	the	the	DET
admet-280	274	7	ugt1a1	ugt1a1	PROPN
admet-280	274	8	*	*	ADJ
admet-280	274	9	28	28	NUM
admet-280	274	10	allele	allele	NOUN
admet-280	274	11	is	be	AUX
admet-280	274	12	associated	associate	VERB
admet-280	274	13	with	with	ADP
admet-280	274	14	development	development	NOUN
admet-280	274	15	of	of	ADP
admet-280	274	16	toxicity	toxicity	NOUN
admet-280	274	17	following	follow	VERB
admet-280	274	18	administration	administration	NOUN
admet-280	274	19	of	of	ADP
admet-280	274	20	the	the	DET
admet-280	274	21	chemotherapeutic	chemotherapeutic	ADJ
admet-280	274	22	irinotecan	irinotecan	NOUN
admet-280	274	23	(	(	PUNCT
admet-280	274	24	the	the	DET
admet-280	274	25	pharmacogenomics	pharmacogenomics	PROPN
admet-280	274	26	knowledge	knowledge	PROPN
admet-280	274	27	base	base	PROPN
admet-280	274	28	:	:	PUNCT
admet-280	274	29	https://www.pharmgkb.org	https://www.pharmgkb.org	NUM
admet-280	274	30	)	)	PUNCT
admet-280	275	1	[	[	X
admet-280	275	2	50	50	NUM
admet-280	275	3	]	]	PUNCT
admet-280	275	4	.	.	PUNCT
admet-280	276	1	additionally	additionally	ADV
admet-280	276	2	,	,	PUNCT
admet-280	276	3	lines	line	NOUN
admet-280	276	4	h1	h1	PROPN
admet-280	276	5	,	,	PUNCT
admet-280	276	6	h7	h7	PROPN
admet-280	276	7	,	,	PUNCT
admet-280	276	8	and	and	CCONJ
admet-280	276	9	h14	h14	NOUN
admet-280	276	10	are	be	AUX
admet-280	276	11	heterozygous	heterozygous	ADJ
admet-280	276	12	for	for	ADP
admet-280	276	13	the	the	DET
admet-280	276	14	nat2	nat2	PROPN
admet-280	276	15	*	*	NUM
admet-280	276	16	5	5	NUM
admet-280	276	17	allele	allele	NOUN
admet-280	276	18	and	and	CCONJ
admet-280	276	19	h13	h13	NOUN
admet-280	276	20	is	be	AUX
admet-280	276	21	homozygous	homozygous	ADJ
admet-280	276	22	for	for	ADP
admet-280	276	23	this	this	DET
admet-280	276	24	allele	allele	NOUN
admet-280	276	25	,	,	PUNCT
admet-280	276	26	likely	likely	ADV
admet-280	276	27	resulting	result	VERB
admet-280	276	28	in	in	ADP
admet-280	276	29	slow	slow	ADJ
admet-280	276	30	acetylator	acetylator	NOUN
admet-280	276	31	status	status	NOUN
admet-280	276	32	for	for	ADP
admet-280	276	33	these	these	DET
admet-280	276	34	cell	cell	NOUN
admet-280	276	35	lines	line	NOUN
admet-280	276	36	.	.	PUNCT
admet-280	277	1	the	the	DET
admet-280	277	2	affymetrix	affymetrix	ADJ
admet-280	277	3	dmet	dmet	NOUN
admet-280	277	4	™	™	VERB
admet-280	277	5	array	array	VERB
admet-280	277	6	genotyping	genotype	VERB
admet-280	277	7	results	result	NOUN
admet-280	277	8	in	in	ADP
admet-280	277	9	their	their	PRON
admet-280	277	10	entirety	entirety	NOUN
admet-280	277	11	can	can	AUX
admet-280	277	12	be	be	AUX
admet-280	277	13	accessed	access	VERB
admet-280	277	14	from	from	ADP
admet-280	277	15	gene	gene	NOUN
admet-280	277	16	expression	expression	NOUN
admet-280	277	17	omnibus	omnibus	NOUN
admet-280	277	18	(	(	PUNCT
admet-280	277	19	geo	geo	PROPN
admet-280	277	20	):	):	PUNCT
admet-280	277	21	(	(	PUNCT
admet-280	277	22	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc	ADV
admet-280	277	23	=	=	SYM
admet-280	277	24	gse53889	gse53889	VERB
admet-280	277	25	;	;	PUNCT
admet-280	277	26	accession	accession	NOUN
admet-280	277	27	:	:	PUNCT
admet-280	277	28	gse53889	gse53889	NOUN
admet-280	277	29	)	)	PUNCT
admet-280	277	30	.	.	PUNCT
admet-280	278	1	table	table	NOUN
admet-280	278	2	3	3	NUM
admet-280	278	3	.	.	NOUN
admet-280	278	4	cyp	cyp	ADJ
admet-280	278	5	genotyping	genotyping	NOUN
admet-280	278	6	results	result	NOUN
admet-280	278	7	.	.	PUNCT
admet-280	279	1	a	a	DET
admet-280	279	2	summary	summary	NOUN
admet-280	279	3	of	of	ADP
admet-280	279	4	cyp	cyp	ADJ
admet-280	279	5	genotyping	genotyping	NOUN
admet-280	279	6	results	result	NOUN
admet-280	279	7	for	for	ADP
admet-280	279	8	wicell	wicell	PROPN
admet-280	279	9	®	®	PROPN
admet-280	279	10	hesc	hesc	PROPN
admet-280	279	11	lines	lines	PROPN
admet-280	279	12	h1	h1	PROPN
admet-280	279	13	,	,	PUNCT
admet-280	279	14	h7	h7	PROPN
admet-280	279	15	,	,	PUNCT
admet-280	279	16	h9	h9	NOUN
admet-280	279	17	,	,	PUNCT
admet-280	279	18	h13	h13	NOUN
admet-280	279	19	,	,	PUNCT
admet-280	279	20	and	and	CCONJ
admet-280	279	21	h14	h14	NOUN
admet-280	279	22	.	.	PUNCT
admet-280	280	1	common	common	ADJ
admet-280	280	2	name	name	NOUN
admet-280	280	3	probe	probe	NOUN
admet-280	280	4	set	set	VERB
admet-280	280	5	i	i	PRON
admet-280	280	6	d	d	PROPN
admet-280	280	7	h1	h1	PROPN
admet-280	280	8	h7	h7	PROPN
admet-280	280	9	h9	h9	PROPN
admet-280	280	10	h13	h13	PROPN
admet-280	280	11	h14	h14	NOUN
admet-280	280	12	cyp1a2	cyp1a2	PROPN
admet-280	280	13	*	*	PROPN
admet-280	280	14	1f	1f	PROPN
admet-280	280	15	-163c	-163c	NOUN
admet-280	280	16	>	>	X
admet-280	280	17	a	a	DET
admet-280	280	18	am_10785	am_10785	PROPN
admet-280	280	19	a	a	NOUN
admet-280	280	20	/	/	SYM
admet-280	280	21	a	a	PRON
admet-280	280	22	c	c	NOUN
admet-280	280	23	/	/	SYM
admet-280	280	24	c	c	PROPN
admet-280	280	25	a	a	NOUN
admet-280	280	26	/	/	SYM
admet-280	280	27	c	c	NOUN
admet-280	280	28	c	c	NOUN
admet-280	280	29	/	/	SYM
admet-280	280	30	c	c	PROPN
admet-280	280	31	a	a	PROPN
admet-280	280	32	/	/	SYM
admet-280	280	33	c	c	NOUN
admet-280	280	34	cyp2a6	cyp2a6	NOUN
admet-280	280	35	deletion	deletion	NOUN
admet-280	280	36	cn_cyp2a6	cn_cyp2a6	ADJ
admet-280	280	37	one	one	NUM
admet-280	280	38	or	or	CCONJ
admet-280	280	39	more	more	ADJ
admet-280	280	40	one	one	NUM
admet-280	280	41	or	or	CCONJ
admet-280	280	42	more	more	ADJ
admet-280	280	43	one	one	NUM
admet-280	280	44	or	or	CCONJ
admet-280	280	45	more	more	ADJ
admet-280	280	46	one	one	NUM
admet-280	280	47	or	or	CCONJ
admet-280	280	48	more	more	ADJ
admet-280	280	49	one	one	NUM
admet-280	280	50	or	or	CCONJ
admet-280	280	51	more	more	ADJ
admet-280	280	52	cyp2b6	cyp2b6	NOUN
admet-280	280	53	*	*	NOUN
admet-280	280	54	5	5	NUM
admet-280	280	55	25505c	25505c	NUM
admet-280	280	56	>	>	SYM
admet-280	280	57	t	t	PROPN
admet-280	280	58	am_11426	am_11426	NOUN
admet-280	280	59	c	c	PROPN
admet-280	280	60	/	/	SYM
admet-280	280	61	c	c	NOUN
admet-280	280	62	c	c	PROPN
admet-280	280	63	/	/	SYM
admet-280	280	64	t	t	PROPN
admet-280	280	65	c	c	X
admet-280	280	66	/	/	SYM
admet-280	280	67	c	c	NOUN
admet-280	280	68	c	c	PROPN
admet-280	280	69	/	/	SYM
admet-280	280	70	t	t	PROPN
admet-280	280	71	c	c	PROPN
admet-280	280	72	/	/	SYM
admet-280	280	73	t	t	PROPN
admet-280	280	74	cyp2b6	cyp2b6	NOUN
admet-280	280	75	*	*	PROPN
admet-280	280	76	6	6	NUM
admet-280	280	77	15631g	15631g	NUM
admet-280	280	78	>	>	X
admet-280	280	79	t	t	PROPN
admet-280	280	80	am_11411	am_11411	VERB
admet-280	280	81	g	g	NOUN
admet-280	280	82	/	/	SYM
admet-280	280	83	g	g	NOUN
admet-280	280	84	no	no	DET
admet-280	280	85	call	call	NOUN
admet-280	280	86	no	no	DET
admet-280	280	87	call	call	NOUN
admet-280	280	88	g	g	NOUN
admet-280	280	89	/	/	SYM
admet-280	280	90	g	g	NOUN
admet-280	280	91	g	g	PROPN
admet-280	280	92	/	/	SYM
admet-280	280	93	t	t	PROPN
admet-280	280	94	cyp2c9	cyp2c9	NOUN
admet-280	280	95	*	*	PROPN
admet-280	280	96	2	2	NUM
admet-280	280	97	3608c	3608c	NUM
admet-280	280	98	>	>	X
admet-280	280	99	t	t	PROPN
admet-280	280	100	am_10100	am_10100	VERB
admet-280	280	101	c	c	AUX
admet-280	280	102	/	/	SYM
admet-280	280	103	c	c	NOUN
admet-280	280	104	c	c	NOUN
admet-280	280	105	/	/	SYM
admet-280	280	106	c	c	NOUN
admet-280	280	107	c	c	X
admet-280	280	108	/	/	SYM
admet-280	280	109	c	c	NOUN
admet-280	280	110	c	c	PROPN
admet-280	280	111	/	/	SYM
admet-280	280	112	c	c	PROPN
admet-280	280	113	t	t	PROPN
admet-280	280	114	/	/	SYM
admet-280	280	115	t	t	PROPN
admet-280	280	116	cyp2c9	cyp2c9	PROPN
admet-280	280	117	*	*	PROPN
admet-280	280	118	3	3	NUM
admet-280	280	119	42614a	42614a	NUM
admet-280	280	120	>	>	X
admet-280	280	121	c	c	PROPN
admet-280	280	122	am_10113	am_10113	PROPN
admet-280	280	123	a	a	PROPN
admet-280	280	124	/	/	SYM
admet-280	280	125	c	c	NOUN
admet-280	280	126	a	a	NOUN
admet-280	280	127	/	/	SYM
admet-280	280	128	a	a	DET
admet-280	280	129	a	a	NOUN
admet-280	280	130	/	/	SYM
admet-280	280	131	a	a	PRON
admet-280	280	132	a	a	NOUN
admet-280	280	133	/	/	SYM
admet-280	280	134	a	a	DET
admet-280	280	135	a	a	NOUN
admet-280	280	136	/	/	SYM
admet-280	280	137	a	a	DET
admet-280	280	138	cyp2c19	cyp2c19	NOUN
admet-280	280	139	*	*	PROPN
admet-280	280	140	2	2	NUM
admet-280	280	141	19154g	19154g	NOUN
admet-280	280	142	>	>	X
admet-280	280	143	a	a	PRON
admet-280	280	144	am_10070	am_10070	NOUN
admet-280	280	145	g	g	NOUN
admet-280	280	146	/	/	SYM
admet-280	280	147	g	g	NOUN
admet-280	280	148	g	g	NOUN
admet-280	280	149	/	/	SYM
admet-280	280	150	g	g	NOUN
admet-280	280	151	g	g	NOUN
admet-280	280	152	/	/	SYM
admet-280	280	153	g	g	NOUN
admet-280	280	154	g	g	NOUN
admet-280	280	155	/	/	SYM
admet-280	280	156	g	g	NOUN
admet-280	280	157	g	g	PROPN
admet-280	280	158	/	/	SYM
admet-280	280	159	g	g	NOUN
admet-280	280	160	cyp2c19	cyp2c19	NOUN
admet-280	280	161	*	*	PROPN
admet-280	280	162	3	3	NUM
admet-280	280	163	17948g	17948g	NUM
admet-280	280	164	>	>	PUNCT
admet-280	280	165	a	a	PRON
admet-280	280	166	am_10068	am_10068	VERB
admet-280	280	167	g	g	NOUN
admet-280	280	168	/	/	SYM
admet-280	280	169	g	g	NOUN
admet-280	280	170	g	g	NOUN
admet-280	280	171	/	/	SYM
admet-280	280	172	g	g	NOUN
admet-280	280	173	g	g	NOUN
admet-280	280	174	/	/	SYM
admet-280	280	175	g	g	NOUN
admet-280	280	176	g	g	NOUN
admet-280	280	177	/	/	SYM
admet-280	280	178	g	g	NOUN
admet-280	280	179	g	g	PROPN
admet-280	280	180	/	/	SYM
admet-280	280	181	g	g	PROPN
admet-280	280	182	cyp2c19	cyp2c19	PROPN
admet-280	280	183	*	*	PROPN
admet-280	280	184	17	17	NUM
admet-280	280	185	-806c	-806c	PROPN
admet-280	280	186	>	>	X
admet-280	280	187	t	t	PROPN
admet-280	281	1	am_10053	am_10053	PROPN
admet-280	282	1	c	c	X
admet-280	282	2	/	/	SYM
admet-280	282	3	t	t	PROPN
admet-280	282	4	c	c	X
admet-280	282	5	/	/	SYM
admet-280	282	6	c	c	NOUN
admet-280	282	7	c	c	PROPN
admet-280	282	8	/	/	SYM
admet-280	282	9	t	t	PROPN
admet-280	282	10	c	c	X
admet-280	282	11	/	/	SYM
admet-280	282	12	c	c	NOUN
admet-280	282	13	c	c	PROPN
admet-280	282	14	/	/	SYM
admet-280	282	15	c	c	NOUN
admet-280	282	16	cyp2e1	cyp2e1	ADJ
admet-280	282	17	*	*	SYM
admet-280	282	18	2	2	NUM
admet-280	282	19	1132g	1132g	NOUN
admet-280	282	20	>	>	X
admet-280	282	21	a	a	PRON
admet-280	282	22	am_10249	am_10249	NOUN
admet-280	282	23	g	g	NOUN
admet-280	282	24	/	/	SYM
admet-280	282	25	g	g	NOUN
admet-280	282	26	g	g	NOUN
admet-280	282	27	/	/	SYM
admet-280	282	28	g	g	NOUN
admet-280	282	29	g	g	NOUN
admet-280	282	30	/	/	SYM
admet-280	282	31	g	g	NOUN
admet-280	282	32	g	g	NOUN
admet-280	282	33	/	/	SYM
admet-280	282	34	g	g	NOUN
admet-280	282	35	g	g	NOUN
admet-280	282	36	/	/	SYM
admet-280	282	37	g	g	NOUN
admet-280	282	38	cyp3a5	cyp3a5	NOUN
admet-280	282	39	*	*	SYM
admet-280	282	40	3	3	NUM
admet-280	282	41	6986a	6986a	NOUN
admet-280	282	42	>	>	SYM
admet-280	282	43	g	g	PROPN
admet-280	282	44	am_14759	am_14759	ADP
admet-280	282	45	g	g	NOUN
admet-280	282	46	/	/	SYM
admet-280	282	47	g	g	NOUN
admet-280	282	48	g	g	NOUN
admet-280	282	49	/	/	SYM
admet-280	282	50	g	g	NOUN
admet-280	282	51	g	g	NOUN
admet-280	282	52	/	/	SYM
admet-280	282	53	g	g	NOUN
admet-280	282	54	g	g	NOUN
admet-280	282	55	/	/	SYM
admet-280	282	56	g	g	NOUN
admet-280	282	57	g	g	NOUN
admet-280	282	58	/	/	SYM
admet-280	282	59	g	g	NOUN
admet-280	282	60	cyp3a5	cyp3a5	NOUN
admet-280	282	61	*	*	NUM
admet-280	282	62	6	6	NUM
admet-280	282	63	14690g	14690g	NUM
admet-280	282	64	>	>	PUNCT
admet-280	282	65	a	a	DET
admet-280	282	66	am_14748	am_14748	NOUN
admet-280	282	67	g	g	NOUN
admet-280	282	68	/	/	SYM
admet-280	282	69	g	g	NOUN
admet-280	282	70	g	g	NOUN
admet-280	282	71	/	/	SYM
admet-280	282	72	g	g	NOUN
admet-280	282	73	g	g	NOUN
admet-280	282	74	/	/	SYM
admet-280	282	75	g	g	NOUN
admet-280	282	76	g	g	NOUN
admet-280	282	77	/	/	SYM
admet-280	282	78	g	g	NOUN
admet-280	282	79	g	g	PROPN
admet-280	282	80	/	/	SYM
admet-280	282	81	g	g	PROPN
admet-280	282	82	cyp3a7	cyp3a7	PROPN
admet-280	282	83	*	*	PROPN
admet-280	282	84	1c	1c	NUM
admet-280	282	85	-232a	-232a	NOUN
admet-280	282	86	>	>	X
admet-280	282	87	c	c	X
admet-280	283	1	am_14791	am_14791	PRON
admet-280	283	2	a	a	X
admet-280	283	3	/	/	SYM
admet-280	283	4	a	a	DET
admet-280	283	5	a	a	NOUN
admet-280	283	6	/	/	SYM
admet-280	283	7	a	a	PRON
admet-280	283	8	a	a	NOUN
admet-280	283	9	/	/	SYM
admet-280	283	10	a	a	PRON
admet-280	283	11	a	a	NOUN
admet-280	283	12	/	/	SYM
admet-280	283	13	a	a	DET
admet-280	283	14	a	a	NOUN
admet-280	283	15	/	/	SYM
admet-280	283	16	a	a	DET
admet-280	283	17	cyp3a7	cyp3a7	NOUN
admet-280	283	18	*	*	SYM
admet-280	283	19	1c	1c	NUM
admet-280	283	20	-284t	-284t	NOUN
admet-280	283	21	>	>	X
admet-280	283	22	a	a	DET
admet-280	283	23	am_14796	am_14796	PROPN
admet-280	283	24	t	t	PROPN
admet-280	283	25	/	/	SYM
admet-280	283	26	t	t	PROPN
admet-280	283	27	t	t	PROPN
admet-280	283	28	/	/	SYM
admet-280	283	29	t	t	PROPN
admet-280	283	30	t	t	PROPN
admet-280	283	31	/	/	SYM
admet-280	283	32	t	t	PROPN
admet-280	283	33	t	t	PROPN
admet-280	283	34	/	/	SYM
admet-280	283	35	t	t	PROPN
admet-280	283	36	t	t	PROPN
admet-280	283	37	/	/	SYM
admet-280	283	38	t	t	PROPN
admet-280	283	39	cyp3a7	cyp3a7	NOUN
admet-280	283	40	*	*	PROPN
admet-280	283	41	2	2	NUM
admet-280	283	42	26041c	26041c	NOUN
admet-280	283	43	>	>	X
admet-280	283	44	g	g	NOUN
admet-280	283	45	am_14781	am_14781	INTJ
admet-280	283	46	c	c	X
admet-280	283	47	/	/	SYM
admet-280	283	48	c	c	NOUN
admet-280	283	49	c	c	X
admet-280	283	50	/	/	SYM
admet-280	283	51	c	c	NOUN
admet-280	283	52	c	c	X
admet-280	283	53	/	/	SYM
admet-280	283	54	c	c	NOUN
admet-280	283	55	c	c	X
admet-280	283	56	/	/	SYM
admet-280	283	57	c	c	NOUN
admet-280	283	58	c	c	X
admet-280	283	59	/	/	SYM
admet-280	283	60	c	c	NOUN
admet-280	283	61	https://www.pharmgkb.org/	https://www.pharmgkb.org/	NOUN
admet-280	284	1	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc%20=gse53889	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc%20=gse53889	NOUN
admet-280	284	2	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc%20=gse53889	http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc%20=gse53889	PROPN
admet-280	284	3	admet	admet	PROPN
admet-280	284	4	&	&	CCONJ
admet-280	284	5	dmpk	dmpk	PROPN
admet-280	284	6	4(2	4(2	NUM
admet-280	284	7	)	)	PUNCT
admet-280	284	8	(	(	PUNCT
admet-280	284	9	2016	2016	NUM
admet-280	284	10	)	)	PUNCT
admet-280	284	11	62	62	NUM
admet-280	284	12	-	-	SYM
admet-280	284	13	83	83	NUM
admet-280	284	14	pharmacogenetics	pharmacogenetic	NOUN
admet-280	284	15	and	and	CCONJ
admet-280	284	16	cyp	cyp	ADJ
admet-280	284	17	activity	activity	NOUN
admet-280	284	18	doi	doi	NOUN
admet-280	284	19	:	:	PUNCT
admet-280	284	20	10.5599	10.5599	NUM
admet-280	284	21	/	/	SYM
admet-280	284	22	admet.4.2.280	admet.4.2.280	NOUN
admet-280	284	23	75	75	NUM
admet-280	284	24	for	for	ADP
admet-280	284	25	use	use	NOUN
admet-280	284	26	in	in	ADP
admet-280	284	27	preclinical	preclinical	ADJ
admet-280	284	28	drug	drug	NOUN
admet-280	284	29	metabolism	metabolism	NOUN
admet-280	284	30	screening	screen	VERB
admet-280	284	31	assays	assay	NOUN
admet-280	284	32	,	,	PUNCT
admet-280	284	33	vendors	vendor	NOUN
admet-280	284	34	commonly	commonly	ADV
admet-280	284	35	offer	offer	AUX
admet-280	284	36	pooled	pool	VERB
admet-280	284	37	donor	donor	NOUN
admet-280	284	38	lots	lot	NOUN
admet-280	284	39	of	of	ADP
admet-280	284	40	hepatocytes	hepatocyte	NOUN
admet-280	284	41	to	to	PART
admet-280	284	42	mitigate	mitigate	VERB
admet-280	284	43	the	the	DET
admet-280	284	44	effects	effect	NOUN
admet-280	284	45	of	of	ADP
admet-280	284	46	interindividual	interindividual	ADJ
admet-280	284	47	variability	variability	NOUN
admet-280	284	48	.	.	PUNCT
admet-280	285	1	with	with	ADP
admet-280	285	2	this	this	PRON
admet-280	285	3	in	in	ADP
admet-280	285	4	mind	mind	NOUN
admet-280	285	5	,	,	PUNCT
admet-280	285	6	the	the	DET
admet-280	285	7	h1	h1	NOUN
admet-280	285	8	line	line	NOUN
admet-280	285	9	has	have	VERB
admet-280	285	10	one	one	NUM
admet-280	285	11	copy	copy	NOUN
admet-280	285	12	of	of	ADP
admet-280	285	13	cyp2d6	cyp2d6	NOUN
admet-280	285	14	,	,	PUNCT
admet-280	285	15	making	make	VERB
admet-280	285	16	it	it	PRON
admet-280	285	17	a	a	DET
admet-280	285	18	predicted	predict	VERB
admet-280	285	19	poor	poor	ADJ
admet-280	285	20	metabolizer	metabolizer	NOUN
admet-280	285	21	in	in	ADP
admet-280	285	22	human	human	ADJ
admet-280	285	23	hepatocytes	hepatocyte	NOUN
admet-280	285	24	,	,	PUNCT
admet-280	285	25	meaning	mean	VERB
admet-280	285	26	scdhs	scdhs	PROPN
admet-280	285	27	generated	generate	VERB
admet-280	285	28	from	from	ADP
admet-280	285	29	hesc	hesc	PROPN
admet-280	285	30	line	line	NOUN
admet-280	285	31	h1	h1	PROPN
admet-280	285	32	may	may	AUX
admet-280	285	33	not	not	PART
admet-280	285	34	metabolize	metabolize	VERB
admet-280	285	35	cyp2d6	cyp2d6	NOUN
admet-280	285	36	probe	probe	NOUN
admet-280	285	37	drugs	drug	NOUN
admet-280	285	38	at	at	ADP
admet-280	285	39	a	a	DET
admet-280	285	40	level	level	NOUN
admet-280	285	41	comparable	comparable	ADJ
admet-280	285	42	to	to	ADP
admet-280	285	43	primary	primary	ADJ
admet-280	285	44	hepatocytes	hepatocyte	NOUN
admet-280	285	45	.	.	PUNCT
admet-280	286	1	in	in	ADP
admet-280	286	2	this	this	DET
admet-280	286	3	case	case	NOUN
admet-280	286	4	it	it	PRON
admet-280	286	5	would	would	AUX
admet-280	286	6	be	be	AUX
admet-280	286	7	important	important	ADJ
admet-280	286	8	to	to	PART
admet-280	286	9	ensure	ensure	VERB
admet-280	286	10	that	that	SCONJ
admet-280	286	11	a	a	DET
admet-280	286	12	lot	lot	NOUN
admet-280	286	13	of	of	ADP
admet-280	286	14	single	single	ADJ
admet-280	286	15	donor	donor	NOUN
admet-280	286	16	human	human	ADJ
admet-280	286	17	primary	primary	ADJ
admet-280	286	18	hepatocytes	hepatocyte	NOUN
admet-280	286	19	used	use	VERB
admet-280	286	20	for	for	ADP
admet-280	286	21	comparison	comparison	NOUN
admet-280	286	22	with	with	ADP
admet-280	286	23	h1	h1	NOUN
admet-280	286	24	-	-	PUNCT
admet-280	286	25	derived	derive	VERB
admet-280	286	26	scdhs	scdhs	NOUN
admet-280	286	27	have	have	AUX
admet-280	286	28	been	be	AUX
admet-280	286	29	characterized	characterize	VERB
admet-280	286	30	as	as	ADP
admet-280	286	31	a	a	DET
admet-280	286	32	cyp2d6	cyp2d6	NOUN
admet-280	286	33	poor	poor	ADJ
admet-280	286	34	metabolizer	metabolizer	NOUN
admet-280	286	35	.	.	PUNCT
admet-280	287	1	regarding	regard	VERB
admet-280	287	2	other	other	ADJ
admet-280	287	3	cyp	cyp	ADJ
admet-280	287	4	isozymes	isozyme	NOUN
admet-280	287	5	,	,	PUNCT
admet-280	287	6	a	a	DET
admet-280	287	7	commonly	commonly	ADV
admet-280	287	8	used	use	VERB
admet-280	287	9	activity	activity	NOUN
admet-280	287	10	test	test	NOUN
admet-280	287	11	in	in	ADP
admet-280	287	12	scdhs	scdhs	PROPN
admet-280	287	13	is	be	AUX
admet-280	287	14	an	an	DET
admet-280	287	15	ethoxyresorufin	ethoxyresorufin	NOUN
admet-280	287	16	-	-	PUNCT
admet-280	287	17	o	o	NOUN
admet-280	287	18	-	-	NOUN
admet-280	287	19	deethylase	deethylase	PROPN
admet-280	287	20	(	(	PUNCT
admet-280	287	21	erod	erod	PROPN
admet-280	287	22	)	)	PUNCT
admet-280	287	23	assay	assay	VERB
admet-280	287	24	for	for	ADP
admet-280	287	25	cyp1a	cyp1a	NOUN
admet-280	287	26	activity	activity	NOUN
admet-280	287	27	and	and	CCONJ
admet-280	287	28	inducibility	inducibility	NOUN
admet-280	287	29	[	[	X
admet-280	287	30	11	11	NUM
admet-280	287	31	,	,	PUNCT
admet-280	287	32	19	19	NUM
admet-280	287	33	,	,	PUNCT
admet-280	287	34	51	51	NUM
admet-280	287	35	,	,	PUNCT
admet-280	287	36	52	52	NUM
admet-280	287	37	]	]	PUNCT
admet-280	287	38	.	.	PUNCT
admet-280	288	1	our	our	PRON
admet-280	288	2	genotyping	genotyping	NOUN
admet-280	288	3	results	result	NOUN
admet-280	288	4	show	show	VERB
admet-280	288	5	the	the	DET
admet-280	288	6	h1	h1	ADJ
admet-280	288	7	line	line	NOUN
admet-280	288	8	to	to	PART
admet-280	288	9	be	be	AUX
admet-280	288	10	homozygous	homozygous	ADJ
admet-280	288	11	and	and	CCONJ
admet-280	288	12	h9	h9	NOUN
admet-280	288	13	to	to	PART
admet-280	288	14	be	be	AUX
admet-280	288	15	heterozygous	heterozygous	ADJ
admet-280	288	16	for	for	ADP
admet-280	288	17	cyp1a2	cyp1a2	PROPN
admet-280	288	18	*	*	PROPN
admet-280	288	19	1f	1f	NUM
admet-280	288	20	,	,	PUNCT
admet-280	288	21	an	an	DET
admet-280	288	22	allele	allele	NOUN
admet-280	288	23	which	which	PRON
admet-280	288	24	has	have	AUX
admet-280	288	25	been	be	AUX
admet-280	288	26	shown	show	VERB
admet-280	288	27	to	to	PART
admet-280	288	28	influence	influence	VERB
admet-280	288	29	the	the	DET
admet-280	288	30	magnitude	magnitude	NOUN
admet-280	288	31	of	of	ADP
admet-280	288	32	inducibility	inducibility	NOUN
admet-280	288	33	of	of	ADP
admet-280	288	34	cyp1a2	cyp1a2	PROPN
admet-280	289	1	[	[	X
admet-280	289	2	48	48	NUM
admet-280	289	3	,	,	PUNCT
admet-280	289	4	53	53	NUM
admet-280	289	5	]	]	PUNCT
admet-280	289	6	.	.	PUNCT
admet-280	290	1	table	table	NOUN
admet-280	290	2	4	4	NUM
admet-280	290	3	.	.	PUNCT
admet-280	290	4	phase	phase	PROPN
admet-280	290	5	ii	ii	PROPN
admet-280	290	6	/	/	SYM
admet-280	290	7	iii	iii	NUM
admet-280	290	8	genotyping	genotyping	NOUN
admet-280	290	9	results	result	NOUN
admet-280	290	10	.	.	PUNCT
admet-280	291	1	a	a	DET
admet-280	291	2	summary	summary	NOUN
admet-280	291	3	of	of	ADP
admet-280	291	4	genotyping	genotyping	NOUN
admet-280	291	5	results	result	NOUN
admet-280	291	6	for	for	ADP
admet-280	291	7	phase	phase	NOUN
admet-280	291	8	ii	ii	PROPN
admet-280	291	9	and	and	CCONJ
admet-280	291	10	iii	iii	NUM
admet-280	291	11	enzymes	enzyme	NOUN
admet-280	291	12	for	for	ADP
admet-280	291	13	wicell	wicell	PROPN
admet-280	291	14	®	®	PROPN
admet-280	291	15	hesc	hesc	PROPN
admet-280	291	16	lines	lines	PROPN
admet-280	291	17	h1	h1	PROPN
admet-280	291	18	,	,	PUNCT
admet-280	291	19	h7	h7	PROPN
admet-280	291	20	,	,	PUNCT
admet-280	291	21	h9	h9	NOUN
admet-280	291	22	,	,	PUNCT
admet-280	291	23	h13	h13	NOUN
admet-280	291	24	,	,	PUNCT
admet-280	291	25	and	and	CCONJ
admet-280	291	26	h14	h14	NOUN
admet-280	291	27	.	.	PUNCT
admet-280	292	1	common	common	ADJ
admet-280	292	2	name	name	NOUN
admet-280	292	3	probe	probe	NOUN
admet-280	292	4	set	set	VERB
admet-280	292	5	i	i	PRON
admet-280	292	6	d	d	PROPN
admet-280	292	7	h1	h1	PROPN
admet-280	292	8	h7	h7	PROPN
admet-280	292	9	h9	h9	PROPN
admet-280	292	10	h13	h13	NOUN
admet-280	292	11	h14	h14	NOUN
admet-280	292	12	aldh2	aldh2	PROPN
admet-280	292	13	1510g	1510g	NUM
admet-280	292	14	>	>	X
admet-280	292	15	a	a	DET
admet-280	292	16	am_10586	am_10586	ADJ
admet-280	292	17	g	g	NOUN
admet-280	292	18	/	/	SYM
admet-280	292	19	g	g	NOUN
admet-280	292	20	g	g	NOUN
admet-280	292	21	/	/	SYM
admet-280	292	22	g	g	NOUN
admet-280	292	23	g	g	NOUN
admet-280	292	24	/	/	SYM
admet-280	292	25	g	g	NOUN
admet-280	292	26	g	g	NOUN
admet-280	292	27	/	/	SYM
admet-280	292	28	g	g	NOUN
admet-280	292	29	g	g	PROPN
admet-280	292	30	/	/	SYM
admet-280	292	31	g	g	PROPN
admet-280	292	32	gstm1	gstm1	NOUN
admet-280	292	33	deletion	deletion	NOUN
admet-280	292	34	cn_gstm	cn_gstm	NOUN
admet-280	292	35	1	1	NUM
admet-280	292	36	one	one	NUM
admet-280	292	37	or	or	CCONJ
admet-280	292	38	more	more	ADJ
admet-280	292	39	0	0	NUM
admet-280	292	40	one	one	NUM
admet-280	292	41	or	or	CCONJ
admet-280	292	42	more	more	ADJ
admet-280	292	43	0	0	NUM
admet-280	292	44	0	0	NUM
admet-280	292	45	gstt1	gstt1	NOUN
admet-280	292	46	deletion	deletion	NOUN
admet-280	292	47	cn_gstt1	cn_gstt1	NOUN
admet-280	292	48	one	one	NUM
admet-280	292	49	or	or	CCONJ
admet-280	292	50	more	more	ADJ
admet-280	292	51	one	one	NUM
admet-280	292	52	or	or	CCONJ
admet-280	292	53	more	more	ADJ
admet-280	292	54	one	one	NUM
admet-280	292	55	or	or	CCONJ
admet-280	292	56	more	more	ADJ
admet-280	292	57	one	one	NUM
admet-280	292	58	or	or	CCONJ
admet-280	292	59	more	more	ADJ
admet-280	292	60	one	one	NUM
admet-280	292	61	or	or	CCONJ
admet-280	292	62	more	more	ADJ
admet-280	292	63	nat1	nat1	NOUN
admet-280	292	64	*	*	PROPN
admet-280	292	65	14	14	NUM
admet-280	292	66	560g	560g	PROPN
admet-280	292	67	>	>	PUNCT
admet-280	292	68	a	a	DET
admet-280	292	69	am_14978	am_14978	ADP
admet-280	292	70	a	a	PRON
admet-280	292	71	/	/	SYM
admet-280	292	72	g	g	NOUN
admet-280	292	73	g	g	PROPN
admet-280	292	74	/	/	SYM
admet-280	292	75	g	g	NOUN
admet-280	292	76	g	g	NOUN
admet-280	292	77	/	/	SYM
admet-280	292	78	g	g	NOUN
admet-280	292	79	g	g	NOUN
admet-280	292	80	/	/	SYM
admet-280	292	81	g	g	NOUN
admet-280	292	82	g	g	PROPN
admet-280	292	83	/	/	SYM
admet-280	292	84	g	g	PROPN
admet-280	292	85	nat2	nat2	NOUN
admet-280	292	86	*	*	NUM
admet-280	292	87	5	5	NUM
admet-280	292	88	341t	341t	PROPN
admet-280	292	89	>	>	X
admet-280	292	90	c	c	PROPN
admet-280	292	91	am_15001	am_15001	PROPN
admet-280	292	92	c	c	X
admet-280	292	93	/	/	SYM
admet-280	292	94	t	t	PROPN
admet-280	292	95	c	c	PROPN
admet-280	292	96	/	/	SYM
admet-280	292	97	t	t	PROPN
admet-280	292	98	t	t	PROPN
admet-280	292	99	/	/	SYM
admet-280	292	100	t	t	PROPN
admet-280	292	101	c	c	X
admet-280	292	102	/	/	SYM
admet-280	292	103	c	c	NOUN
admet-280	292	104	c	c	PROPN
admet-280	292	105	/	/	SYM
admet-280	292	106	t	t	PROPN
admet-280	292	107	sult1a1	sult1a1	PROPN
admet-280	292	108	*	*	PROPN
admet-280	292	109	2	2	NUM
admet-280	292	110	638g	638g	NOUN
admet-280	292	111	>	>	PUNCT
admet-280	292	112	a	a	DET
admet-280	292	113	am_11005	am_11005	NOUN
admet-280	292	114	a	a	NOUN
admet-280	292	115	/	/	SYM
admet-280	292	116	g	g	NOUN
admet-280	292	117	a	a	NOUN
admet-280	292	118	/	/	SYM
admet-280	292	119	g	g	PROPN
admet-280	292	120	a	a	NOUN
admet-280	292	121	/	/	SYM
admet-280	292	122	g	g	NOUN
admet-280	292	123	g	g	PROPN
admet-280	292	124	/	/	SYM
admet-280	292	125	g	g	PROPN
admet-280	292	126	a	a	PROPN
admet-280	292	127	/	/	SYM
admet-280	292	128	g	g	NOUN
admet-280	292	129	tpmt*2	tpmt*2	NUM
admet-280	292	130	238g	238g	NOUN
admet-280	292	131	>	>	PUNCT
admet-280	292	132	c	c	PROPN
admet-280	292	133	am_13986	am_13986	PROPN
admet-280	292	134	g	g	NOUN
admet-280	292	135	/	/	SYM
admet-280	292	136	g	g	NOUN
admet-280	292	137	g	g	NOUN
admet-280	292	138	/	/	SYM
admet-280	292	139	g	g	NOUN
admet-280	292	140	g	g	NOUN
admet-280	292	141	/	/	SYM
admet-280	292	142	g	g	NOUN
admet-280	292	143	g	g	NOUN
admet-280	292	144	/	/	SYM
admet-280	292	145	g	g	NOUN
admet-280	292	146	g	g	NOUN
admet-280	292	147	/	/	SYM
admet-280	292	148	g	g	NOUN
admet-280	292	149	tpmt*3b	tpmt*3b	PROPN
admet-280	292	150	460g	460g	NOUN
admet-280	292	151	>	>	PUNCT
admet-280	292	152	a	a	DET
admet-280	292	153	am_13980	am_13980	PROPN
admet-280	292	154	g	g	NOUN
admet-280	292	155	/	/	SYM
admet-280	292	156	g	g	NOUN
admet-280	292	157	g	g	NOUN
admet-280	292	158	/	/	SYM
admet-280	292	159	g	g	NOUN
admet-280	292	160	g	g	NOUN
admet-280	292	161	/	/	SYM
admet-280	292	162	g	g	NOUN
admet-280	292	163	g	g	NOUN
admet-280	292	164	/	/	SYM
admet-280	292	165	g	g	NOUN
admet-280	292	166	g	g	PROPN
admet-280	292	167	/	/	SYM
admet-280	292	168	g	g	PROPN
admet-280	292	169	tpmt*3c	tpmt*3c	PROPN
admet-280	292	170	719a	719a	PROPN
admet-280	292	171	>	>	SYM
admet-280	292	172	g	g	PROPN
admet-280	292	173	am_13973	am_13973	PROPN
admet-280	292	174	a	a	PRON
admet-280	292	175	/	/	SYM
admet-280	292	176	a	a	DET
admet-280	292	177	a	a	NOUN
admet-280	292	178	/	/	SYM
admet-280	292	179	a	a	PRON
admet-280	292	180	a	a	NOUN
admet-280	292	181	/	/	SYM
admet-280	292	182	a	a	PRON
admet-280	292	183	a	a	NOUN
admet-280	292	184	/	/	SYM
admet-280	292	185	a	a	PRON
admet-280	292	186	a	a	NOUN
admet-280	292	187	/	/	SYM
admet-280	292	188	a	a	DET
admet-280	292	189	tpmt*4	tpmt*4	NUM
admet-280	292	190	626	626	NUM
admet-280	292	191	-	-	PUNCT
admet-280	292	192	1g	1g	NUM
admet-280	292	193	>	>	X
admet-280	292	194	a	a	PRON
admet-280	292	195	am_13977	am_13977	X
admet-280	292	196	g	g	NOUN
admet-280	292	197	/	/	SYM
admet-280	292	198	g	g	NOUN
admet-280	292	199	g	g	NOUN
admet-280	292	200	/	/	SYM
admet-280	292	201	g	g	NOUN
admet-280	292	202	g	g	NOUN
admet-280	292	203	/	/	SYM
admet-280	292	204	g	g	NOUN
admet-280	292	205	g	g	NOUN
admet-280	292	206	/	/	SYM
admet-280	292	207	g	g	NOUN
admet-280	292	208	g	g	PROPN
admet-280	292	209	/	/	SYM
admet-280	292	210	g	g	NOUN
admet-280	292	211	ugt1a1	ugt1a1	NOUN
admet-280	292	212	*	*	PROPN
admet-280	292	213	28	28	NUM
admet-280	292	214	tata	tata	PROPN
admet-280	292	215	-	-	PUNCT
admet-280	292	216	box	box	NOUN
admet-280	292	217	am_13024	am_13024	PROPN
admet-280	292	218	(	(	PUNCT
admet-280	292	219	ta)5or6/	ta)5or6/	X
admet-280	292	220	(	(	PUNCT
admet-280	292	221	ta)5or6	ta)5or6	NUM
admet-280	292	222	(	(	PUNCT
admet-280	292	223	ta)5or6/	ta)5or6/	X
admet-280	292	224	(	(	PUNCT
admet-280	292	225	ta)7or8	ta)7or8	NOUN
admet-280	292	226	(	(	PUNCT
admet-280	292	227	ta)5or6/	ta)5or6/	X
admet-280	292	228	(	(	PUNCT
admet-280	292	229	ta)5or6	ta)5or6	NUM
admet-280	292	230	(	(	PUNCT
admet-280	292	231	ta)5or6/	ta)5or6/	X
admet-280	292	232	(	(	PUNCT
admet-280	292	233	ta)7or8	ta)7or8	NOUN
admet-280	292	234	(	(	PUNCT
admet-280	292	235	ta)5or6/	ta)5or6/	X
admet-280	292	236	(	(	PUNCT
admet-280	292	237	ta)7or8	ta)7or8	X
admet-280	292	238	ugt2b7	ugt2b7	NOUN
admet-280	292	239	*	*	SYM
admet-280	292	240	2	2	NUM
admet-280	292	241	802c	802c	NOUN
admet-280	292	242	>	>	X
admet-280	292	243	t	t	PROPN
admet-280	292	244	am_13465	am_13465	PROPN
admet-280	292	245	t	t	PROPN
admet-280	292	246	/	/	SYM
admet-280	292	247	t	t	PROPN
admet-280	292	248	t	t	PROPN
admet-280	292	249	/	/	SYM
admet-280	292	250	t	t	PROPN
admet-280	292	251	t	t	PROPN
admet-280	292	252	/	/	SYM
admet-280	292	253	t	t	PROPN
admet-280	292	254	c	c	PROPN
admet-280	292	255	/	/	SYM
admet-280	292	256	t	t	PROPN
admet-280	292	257	t	t	PROPN
admet-280	292	258	/	/	SYM
admet-280	292	259	t	t	PROPN
admet-280	292	260	abcb1	abcb1	NOUN
admet-280	292	261	1236c	1236c	NUM
admet-280	292	262	>	>	X
admet-280	292	263	t	t	X
admet-280	292	264	am_14612	am_14612	PROPN
admet-280	292	265	c	c	X
admet-280	292	266	/	/	SYM
admet-280	292	267	t	t	PROPN
admet-280	292	268	c	c	PROPN
admet-280	292	269	/	/	SYM
admet-280	292	270	t	t	PROPN
admet-280	292	271	c	c	PROPN
admet-280	292	272	/	/	SYM
admet-280	292	273	t	t	PROPN
admet-280	292	274	c	c	PROPN
admet-280	292	275	/	/	SYM
admet-280	292	276	t	t	PROPN
admet-280	292	277	c	c	PROPN
admet-280	292	278	/	/	SYM
admet-280	292	279	t	t	PROPN
admet-280	292	280	abcb1	abcb1	NOUN
admet-280	292	281	2677g	2677g	NUM
admet-280	292	282	>	>	X
admet-280	292	283	t	t	PROPN
admet-280	292	284	>	>	X
admet-280	292	285	a	a	DET
admet-280	292	286	am_14592	am_14592	NOUN
admet-280	292	287	g	g	NOUN
admet-280	292	288	/	/	SYM
admet-280	292	289	t	t	PROPN
admet-280	292	290	g	g	PROPN
admet-280	292	291	/	/	SYM
admet-280	292	292	t	t	PROPN
admet-280	292	293	g	g	PROPN
admet-280	292	294	/	/	SYM
admet-280	292	295	t	t	PROPN
admet-280	292	296	g	g	PROPN
admet-280	292	297	/	/	SYM
admet-280	292	298	t	t	PROPN
admet-280	292	299	g	g	PROPN
admet-280	292	300	/	/	SYM
admet-280	292	301	t	t	PROPN
admet-280	292	302	abcb1	abcb1	NOUN
admet-280	292	303	3435c	3435c	NOUN
admet-280	292	304	>	>	X
admet-280	292	305	t	t	X
admet-280	292	306	am_14581	am_14581	X
admet-280	292	307	c	c	PROPN
admet-280	292	308	/	/	SYM
admet-280	292	309	t	t	PROPN
admet-280	292	310	c	c	PROPN
admet-280	292	311	/	/	SYM
admet-280	292	312	t	t	PROPN
admet-280	292	313	c	c	PROPN
admet-280	292	314	/	/	SYM
admet-280	292	315	t	t	PROPN
admet-280	292	316	c	c	PROPN
admet-280	292	317	/	/	SYM
admet-280	292	318	t	t	PROPN
admet-280	292	319	c	c	PROPN
admet-280	292	320	/	/	SYM
admet-280	292	321	t	t	PROPN
admet-280	292	322	abcg2	abcg2	X
admet-280	293	1	421c	421c	ADP
admet-280	293	2	>	>	X
admet-280	293	3	a	a	DET
admet-280	293	4	am_13688	am_13688	ADJ
admet-280	293	5	c	c	NOUN
admet-280	293	6	/	/	SYM
admet-280	293	7	c	c	NOUN
admet-280	293	8	c	c	X
admet-280	293	9	/	/	SYM
admet-280	293	10	c	c	NOUN
admet-280	293	11	c	c	X
admet-280	293	12	/	/	SYM
admet-280	293	13	c	c	NOUN
admet-280	293	14	c	c	X
admet-280	293	15	/	/	SYM
admet-280	293	16	c	c	NOUN
admet-280	293	17	c	c	X
admet-280	293	18	/	/	SYM
admet-280	293	19	c	c	PROPN
admet-280	293	20	slco1a2	slco1a2	PROPN
admet-280	293	21	404a	404a	PROPN
admet-280	293	22	>	>	PROPN
admet-280	293	23	t	t	PROPN
admet-280	293	24	am_10533	am_10533	VERB
admet-280	293	25	a	a	PRON
admet-280	293	26	/	/	SYM
admet-280	293	27	a	a	DET
admet-280	293	28	a	a	NOUN
admet-280	293	29	/	/	SYM
admet-280	293	30	a	a	PRON
admet-280	293	31	a	a	NOUN
admet-280	293	32	/	/	SYM
admet-280	293	33	a	a	DET
admet-280	293	34	a	a	NOUN
admet-280	293	35	/	/	SYM
admet-280	293	36	a	a	DET
admet-280	293	37	a	a	NOUN
admet-280	293	38	/	/	SYM
admet-280	293	39	a	a	DET
admet-280	293	40	slco1a2	slco1a2	NOUN
admet-280	293	41	516a	516a	PROPN
admet-280	293	42	>	>	PUNCT
admet-280	293	43	c	c	PROPN
admet-280	293	44	am_10531	am_10531	PROPN
admet-280	293	45	a	a	X
admet-280	293	46	/	/	SYM
admet-280	293	47	a	a	DET
admet-280	293	48	a	a	NOUN
admet-280	293	49	/	/	SYM
admet-280	293	50	a	a	PRON
admet-280	293	51	a	a	NOUN
admet-280	293	52	/	/	SYM
admet-280	293	53	a	a	PRON
admet-280	293	54	a	a	NOUN
admet-280	293	55	/	/	SYM
admet-280	293	56	a	a	DET
admet-280	293	57	a	a	NOUN
admet-280	293	58	/	/	SYM
admet-280	293	59	a	a	DET
admet-280	293	60	slco1b1	slco1b1	NOUN
admet-280	293	61	*	*	NOUN
admet-280	293	62	1b	1b	NUM
admet-280	293	63	388a	388a	NOUN
admet-280	293	64	>	>	SYM
admet-280	293	65	g	g	PROPN
admet-280	293	66	am_10496	am_10496	NOUN
admet-280	293	67	a	a	PRON
admet-280	293	68	/	/	SYM
admet-280	293	69	g	g	PROPN
admet-280	293	70	a	a	NOUN
admet-280	293	71	/	/	SYM
admet-280	293	72	a	a	DET
admet-280	293	73	a	a	NOUN
admet-280	293	74	/	/	SYM
admet-280	293	75	g	g	NOUN
admet-280	293	76	a	a	NOUN
admet-280	293	77	/	/	SYM
admet-280	293	78	a	a	DET
admet-280	293	79	a	a	NOUN
admet-280	293	80	/	/	SYM
admet-280	293	81	a	a	DET
admet-280	293	82	slco1b1	slco1b1	NOUN
admet-280	293	83	*	*	SYM
admet-280	293	84	4	4	NUM
admet-280	293	85	463c	463c	NOUN
admet-280	293	86	>	>	PUNCT
admet-280	293	87	a	a	DET
admet-280	293	88	am_10498	am_10498	ADJ
admet-280	293	89	c	c	NOUN
admet-280	293	90	/	/	SYM
admet-280	293	91	c	c	NOUN
admet-280	293	92	c	c	X
admet-280	293	93	/	/	SYM
admet-280	293	94	c	c	PROPN
admet-280	293	95	a	a	NOUN
admet-280	293	96	/	/	SYM
admet-280	293	97	c	c	NOUN
admet-280	293	98	c	c	NOUN
admet-280	293	99	/	/	SYM
admet-280	293	100	c	c	NOUN
admet-280	293	101	c	c	NOUN
admet-280	293	102	/	/	SYM
admet-280	293	103	c	c	PROPN
admet-280	293	104	slco1b3	slco1b3	PROPN
admet-280	293	105	334g	334g	PROPN
admet-280	293	106	>	>	X
admet-280	293	107	t	t	PROPN
admet-280	293	108	am_10481	am_10481	NOUN
admet-280	293	109	g	g	NOUN
admet-280	293	110	/	/	SYM
admet-280	293	111	g	g	NOUN
admet-280	293	112	g	g	NOUN
admet-280	293	113	/	/	SYM
admet-280	293	114	g	g	NOUN
admet-280	293	115	g	g	NOUN
admet-280	293	116	/	/	SYM
admet-280	293	117	g	g	NOUN
admet-280	293	118	g	g	NOUN
admet-280	293	119	/	/	SYM
admet-280	293	120	g	g	NOUN
admet-280	293	121	g	g	PROPN
admet-280	293	122	/	/	SYM
admet-280	293	123	g	g	NOUN
admet-280	293	124	slco1b3	slco1b3	PROPN
admet-280	293	125	699a	699a	PROPN
admet-280	293	126	>	>	X
admet-280	293	127	g	g	PROPN
admet-280	293	128	am_10482	am_10482	VERB
admet-280	293	129	a	a	PRON
admet-280	293	130	/	/	SYM
admet-280	293	131	a	a	DET
admet-280	293	132	a	a	NOUN
admet-280	293	133	/	/	SYM
admet-280	293	134	a	a	PRON
admet-280	293	135	a	a	NOUN
admet-280	293	136	/	/	SYM
admet-280	293	137	a	a	PRON
admet-280	293	138	a	a	NOUN
admet-280	293	139	/	/	SYM
admet-280	293	140	a	a	DET
admet-280	293	141	a	a	NOUN
admet-280	293	142	/	/	SYM
admet-280	293	143	a	a	DET
admet-280	293	144	voellinger	voellinger	NOUN
admet-280	294	1	and	and	CCONJ
admet-280	294	2	kelly	kelly	PROPN
admet-280	294	3	admet	admet	PROPN
admet-280	294	4	&	&	CCONJ
admet-280	294	5	dmpk	dmpk	PROPN
admet-280	294	6	4(2	4(2	NUM
admet-280	294	7	)	)	PUNCT
admet-280	294	8	(	(	PUNCT
admet-280	294	9	2016	2016	NUM
admet-280	294	10	)	)	PUNCT
admet-280	294	11	62	62	NUM
admet-280	294	12	-	-	SYM
admet-280	294	13	83	83	NUM
admet-280	294	14	76	76	NUM
admet-280	294	15	the	the	DET
admet-280	294	16	genotyping	genotype	VERB
admet-280	294	17	data	datum	NOUN
admet-280	294	18	presented	present	VERB
admet-280	294	19	here	here	ADV
admet-280	294	20	is	be	AUX
admet-280	294	21	important	important	ADJ
admet-280	294	22	to	to	PART
admet-280	294	23	better	well	ADV
admet-280	294	24	understand	understand	VERB
admet-280	294	25	the	the	DET
admet-280	294	26	activity	activity	NOUN
admet-280	294	27	of	of	ADP
admet-280	294	28	metabolizing	metabolize	VERB
admet-280	294	29	enzymes	enzyme	NOUN
admet-280	294	30	and	and	CCONJ
admet-280	294	31	transporters	transporter	NOUN
admet-280	294	32	when	when	SCONJ
admet-280	294	33	evaluating	evaluate	VERB
admet-280	294	34	metabolism	metabolism	NOUN
admet-280	294	35	of	of	ADP
admet-280	294	36	probe	probe	NOUN
admet-280	294	37	substrates	substrate	NOUN
admet-280	294	38	in	in	ADP
admet-280	294	39	scdhs	scdhs	ADJ
admet-280	294	40	,	,	PUNCT
admet-280	294	41	particularly	particularly	ADV
admet-280	294	42	when	when	SCONJ
admet-280	294	43	being	be	AUX
admet-280	294	44	used	use	VERB
admet-280	294	45	as	as	ADP
admet-280	294	46	a	a	DET
admet-280	294	47	marker	marker	NOUN
admet-280	294	48	to	to	PART
admet-280	294	49	evaluate	evaluate	VERB
admet-280	294	50	the	the	DET
admet-280	294	51	efficiency	efficiency	NOUN
admet-280	294	52	of	of	ADP
admet-280	294	53	differentiation	differentiation	NOUN
admet-280	294	54	of	of	ADP
admet-280	294	55	scdhs	scdhs	NOUN
admet-280	294	56	.	.	PUNCT
admet-280	295	1	the	the	DET
admet-280	295	2	affymetrix	affymetrix	ADJ
admet-280	295	3	dmet	dmet	NOUN
admet-280	295	4	™	™	PROPN
admet-280	295	5	array	array	NOUN
admet-280	295	6	used	use	VERB
admet-280	295	7	for	for	ADP
admet-280	295	8	genotyping	genotype	VERB
admet-280	295	9	in	in	ADP
admet-280	295	10	this	this	DET
admet-280	295	11	study	study	NOUN
admet-280	295	12	provides	provide	VERB
admet-280	295	13	a	a	DET
admet-280	295	14	thorough	thorough	ADJ
admet-280	295	15	evaluation	evaluation	NOUN
admet-280	295	16	of	of	ADP
admet-280	295	17	the	the	DET
admet-280	295	18	major	major	ADJ
admet-280	295	19	known	know	VERB
admet-280	295	20	polymorphisms	polymorphism	NOUN
admet-280	295	21	in	in	ADP
admet-280	295	22	adme	adme	NOUN
admet-280	295	23	-	-	PUNCT
admet-280	295	24	related	relate	VERB
admet-280	295	25	genes	gene	NOUN
admet-280	295	26	.	.	PUNCT
admet-280	296	1	however	however	ADV
admet-280	296	2	,	,	PUNCT
admet-280	296	3	there	there	PRON
admet-280	296	4	are	be	VERB
admet-280	296	5	examples	example	NOUN
admet-280	296	6	when	when	SCONJ
admet-280	296	7	calls	call	NOUN
admet-280	296	8	were	be	AUX
admet-280	296	9	not	not	PART
admet-280	296	10	made	make	VERB
admet-280	296	11	(	(	PUNCT
admet-280	296	12	e.g.	e.g.	ADV
admet-280	296	13	cyp2b6	cyp2b6	NOUN
admet-280	296	14	*	*	PROPN
admet-280	296	15	6	6	NUM
admet-280	296	16	)	)	PUNCT
admet-280	296	17	,	,	PUNCT
admet-280	296	18	such	such	ADJ
admet-280	296	19	that	that	SCONJ
admet-280	296	20	if	if	SCONJ
admet-280	296	21	evaluating	evaluate	VERB
admet-280	296	22	activity	activity	NOUN
admet-280	296	23	of	of	ADP
admet-280	296	24	these	these	DET
admet-280	296	25	proteins	protein	NOUN
admet-280	296	26	,	,	PUNCT
admet-280	296	27	individual	individual	ADJ
admet-280	296	28	genotyping	genotype	VERB
admet-280	296	29	for	for	ADP
admet-280	296	30	these	these	DET
admet-280	296	31	alleles	allele	NOUN
admet-280	296	32	may	may	AUX
admet-280	296	33	be	be	AUX
admet-280	296	34	necessary	necessary	ADJ
admet-280	296	35	.	.	PUNCT
admet-280	297	1	this	this	DET
admet-280	297	2	study	study	NOUN
admet-280	297	3	only	only	ADV
admet-280	297	4	reports	report	VERB
admet-280	297	5	results	result	VERB
admet-280	297	6	for	for	ADP
admet-280	297	7	the	the	DET
admet-280	297	8	five	five	NUM
admet-280	297	9	commonly	commonly	ADV
admet-280	297	10	used	use	VERB
admet-280	297	11	wicell	wicell	PROPN
admet-280	297	12	®	®	NOUN
admet-280	297	13	lines	line	NOUN
admet-280	297	14	,	,	PUNCT
admet-280	297	15	however	however	ADV
admet-280	297	16	this	this	DET
admet-280	297	17	approach	approach	NOUN
admet-280	297	18	to	to	ADP
admet-280	297	19	genotyping	genotyping	NOUN
admet-280	297	20	should	should	AUX
admet-280	297	21	be	be	AUX
admet-280	297	22	considered	consider	VERB
admet-280	297	23	for	for	ADP
admet-280	297	24	all	all	DET
admet-280	297	25	hesc	hesc	NOUN
admet-280	297	26	and	and	CCONJ
admet-280	297	27	human	human	PROPN
admet-280	297	28	ipsc	ipsc	PROPN
admet-280	297	29	lines	line	NOUN
admet-280	297	30	used	use	VERB
admet-280	297	31	as	as	ADP
admet-280	297	32	a	a	DET
admet-280	297	33	target	target	NOUN
admet-280	297	34	cell	cell	NOUN
admet-280	297	35	source	source	NOUN
admet-280	297	36	for	for	ADP
admet-280	297	37	models	model	NOUN
admet-280	297	38	of	of	ADP
admet-280	297	39	drug	drug	NOUN
admet-280	297	40	metabolism	metabolism	NOUN
admet-280	297	41	and	and	CCONJ
admet-280	297	42	toxicity	toxicity	NOUN
admet-280	297	43	.	.	PUNCT
admet-280	298	1	in	in	ADP
admet-280	298	2	particular	particular	ADJ
admet-280	298	3	,	,	PUNCT
admet-280	298	4	if	if	SCONJ
admet-280	298	5	a	a	DET
admet-280	298	6	bank	bank	NOUN
admet-280	298	7	of	of	ADP
admet-280	298	8	hesc	hesc	NOUN
admet-280	298	9	or	or	CCONJ
admet-280	298	10	ipscs	ipscs	NOUN
admet-280	298	11	is	be	AUX
admet-280	298	12	to	to	PART
admet-280	298	13	be	be	AUX
admet-280	298	14	established	establish	VERB
admet-280	298	15	then	then	ADV
admet-280	298	16	the	the	DET
admet-280	298	17	use	use	NOUN
admet-280	298	18	of	of	ADP
admet-280	298	19	a	a	DET
admet-280	298	20	genotyping	genotyping	NOUN
admet-280	298	21	array	array	NOUN
admet-280	298	22	,	,	PUNCT
admet-280	298	23	such	such	ADJ
admet-280	298	24	as	as	ADP
admet-280	298	25	the	the	DET
admet-280	298	26	affymetrix	affymetrix	ADJ
admet-280	298	27	dmet	dmet	NOUN
admet-280	298	28	™	™	NOUN
admet-280	298	29	array	array	NOUN
admet-280	298	30	,	,	PUNCT
admet-280	298	31	should	should	AUX
admet-280	298	32	be	be	AUX
admet-280	298	33	implemented	implement	VERB
admet-280	298	34	with	with	ADP
admet-280	298	35	results	result	NOUN
admet-280	298	36	readily	readily	ADV
admet-280	298	37	available	available	ADJ
admet-280	298	38	to	to	ADP
admet-280	298	39	researchers	researcher	NOUN
admet-280	298	40	.	.	PUNCT
admet-280	299	1	as	as	SCONJ
admet-280	299	2	the	the	DET
admet-280	299	3	cost	cost	NOUN
admet-280	299	4	of	of	ADP
admet-280	299	5	whole	whole	ADJ
admet-280	299	6	genome	genome	NOUN
admet-280	299	7	sequencing	sequencing	NOUN
admet-280	299	8	continues	continue	VERB
admet-280	299	9	to	to	PART
admet-280	299	10	decrease	decrease	VERB
admet-280	299	11	,	,	PUNCT
admet-280	299	12	it	it	PRON
admet-280	299	13	will	will	AUX
admet-280	299	14	become	become	VERB
admet-280	299	15	an	an	DET
admet-280	299	16	attractive	attractive	ADJ
admet-280	299	17	alternative	alternative	NOUN
admet-280	299	18	to	to	ADP
admet-280	299	19	targeted	target	VERB
admet-280	299	20	arrays	array	NOUN
admet-280	299	21	such	such	ADJ
admet-280	299	22	as	as	ADP
admet-280	299	23	what	what	PRON
admet-280	299	24	we	we	PRON
admet-280	299	25	employed	employ	VERB
admet-280	299	26	,	,	PUNCT
admet-280	299	27	with	with	ADP
admet-280	299	28	the	the	DET
admet-280	299	29	caveat	caveat	NOUN
admet-280	299	30	that	that	SCONJ
admet-280	299	31	mining	mine	VERB
admet-280	299	32	these	these	DET
admet-280	299	33	large	large	ADJ
admet-280	299	34	data	data	NOUN
admet-280	299	35	sets	set	NOUN
admet-280	299	36	for	for	ADP
admet-280	299	37	specific	specific	ADJ
admet-280	299	38	adme	adme	NOUN
admet-280	299	39	-	-	PUNCT
admet-280	299	40	related	relate	VERB
admet-280	299	41	polymorphisms	polymorphism	NOUN
admet-280	299	42	is	be	AUX
admet-280	299	43	currently	currently	ADV
admet-280	299	44	challenging	challenging	ADJ
admet-280	299	45	.	.	PUNCT
admet-280	300	1	cyp2d6	cyp2d6	NOUN
admet-280	300	2	*	*	SYM
admet-280	300	3	41	41	NUM
admet-280	300	4	reverse	reverse	NOUN
admet-280	300	5	-	-	PUNCT
admet-280	300	6	transcription	transcription	NOUN
admet-280	300	7	pcr	pcr	NOUN
admet-280	300	8	assay	assay	VERB
admet-280	300	9	aberrant	aberrant	ADJ
admet-280	300	10	splicing	splicing	NOUN
admet-280	300	11	resulting	result	VERB
admet-280	300	12	from	from	ADP
admet-280	300	13	the	the	DET
admet-280	300	14	cyp2d6	cyp2d6	PROPN
admet-280	300	15	*	*	SYM
admet-280	300	16	41	41	NUM
admet-280	300	17	polymorphism	polymorphism	NOUN
admet-280	300	18	was	be	AUX
admet-280	300	19	assessed	assess	VERB
admet-280	300	20	ex	ex	PRON
admet-280	300	21	vivo	vivo	NOUN
admet-280	300	22	with	with	ADP
admet-280	300	23	human	human	ADJ
admet-280	300	24	liver	liver	NOUN
admet-280	300	25	tissue	tissue	NOUN
admet-280	300	26	and	and	CCONJ
admet-280	300	27	in	in	ADP
admet-280	300	28	vitro	vitro	X
admet-280	300	29	using	use	VERB
admet-280	300	30	scdhs	scdhs	NOUN
admet-280	300	31	.	.	PUNCT
admet-280	301	1	to	to	PART
admet-280	301	2	assess	assess	VERB
admet-280	301	3	differentiation	differentiation	NOUN
admet-280	301	4	in	in	ADP
admet-280	301	5	the	the	DET
admet-280	301	6	scdhs	scdhs	NOUN
admet-280	301	7	used	use	VERB
admet-280	301	8	for	for	ADP
admet-280	301	9	cyp2d6	cyp2d6	NOUN
admet-280	301	10	*	*	SYM
admet-280	301	11	41	41	NUM
admet-280	301	12	analysis	analysis	NOUN
admet-280	301	13	,	,	PUNCT
admet-280	301	14	gene	gene	NOUN
admet-280	301	15	expression	expression	NOUN
admet-280	301	16	of	of	ADP
admet-280	301	17	afp	afp	PROPN
admet-280	301	18	,	,	PUNCT
admet-280	301	19	alb	alb	PROPN
admet-280	301	20	,	,	PUNCT
admet-280	301	21	hnf4α	hnf4α	PROPN
admet-280	301	22	,	,	PUNCT
admet-280	301	23	cyp2d6	cyp2d6	NOUN
admet-280	301	24	,	,	PUNCT
admet-280	301	25	cyp3a4	cyp3a4	PROPN
admet-280	301	26	,	,	PUNCT
admet-280	301	27	nanog	nanog	PROPN
admet-280	301	28	and	and	CCONJ
admet-280	301	29	oct4	oct4	PROPN
admet-280	301	30	was	be	AUX
admet-280	301	31	evaluated	evaluate	VERB
admet-280	301	32	,	,	PUNCT
admet-280	301	33	results	result	NOUN
admet-280	301	34	are	be	AUX
admet-280	301	35	reported	report	VERB
admet-280	301	36	as	as	ADP
admet-280	301	37	fold	fold	ADJ
admet-280	301	38	change	change	NOUN
admet-280	301	39	compared	compare	VERB
admet-280	301	40	to	to	ADP
admet-280	301	41	cryopreserved	cryopreserve	VERB
admet-280	301	42	hepatocyte	hepatocyte	NOUN
admet-280	301	43	log	log	NOUN
admet-280	301	44	hum4012	hum4012	NOUN
admet-280	301	45	(	(	PUNCT
admet-280	301	46	figure	figure	NOUN
admet-280	301	47	4a	4a	NUM
admet-280	301	48	)	)	PUNCT
admet-280	301	49	.	.	PUNCT
admet-280	302	1	while	while	SCONJ
admet-280	302	2	expression	expression	NOUN
admet-280	302	3	of	of	ADP
admet-280	302	4	hnf4α	hnf4α	PROPN
admet-280	302	5	in	in	ADP
admet-280	302	6	scdhs	scdhs	NOUN
admet-280	302	7	is	be	AUX
admet-280	302	8	comparable	comparable	ADJ
admet-280	302	9	to	to	ADP
admet-280	302	10	that	that	PRON
admet-280	302	11	seen	see	VERB
admet-280	302	12	in	in	ADP
admet-280	302	13	cryopreserved	cryopreserved	ADJ
admet-280	302	14	hepatocytes	hepatocyte	NOUN
admet-280	302	15	,	,	PUNCT
admet-280	302	16	expression	expression	NOUN
admet-280	302	17	levels	level	NOUN
admet-280	302	18	of	of	ADP
admet-280	302	19	albumin	albumin	NOUN
admet-280	302	20	and	and	CCONJ
admet-280	302	21	cyp3a4	cyp3a4	NOUN
admet-280	302	22	were	be	AUX
admet-280	302	23	lower	low	ADJ
admet-280	302	24	than	than	ADP
admet-280	302	25	that	that	PRON
admet-280	302	26	of	of	ADP
admet-280	302	27	cryopreserved	cryopreserved	ADJ
admet-280	302	28	hepatocytes	hepatocyte	NOUN
admet-280	302	29	.	.	PUNCT
admet-280	303	1	conversely	conversely	ADV
admet-280	303	2	,	,	PUNCT
admet-280	303	3	expression	expression	NOUN
admet-280	303	4	of	of	ADP
admet-280	303	5	afp	afp	PROPN
admet-280	303	6	in	in	ADP
admet-280	303	7	scdhs	scdhs	PROPN
admet-280	303	8	is	be	AUX
admet-280	303	9	higher	high	ADJ
admet-280	303	10	than	than	ADP
admet-280	303	11	that	that	PRON
admet-280	303	12	expressed	express	VERB
admet-280	303	13	in	in	ADP
admet-280	303	14	cryopreserved	cryopreserved	ADJ
admet-280	303	15	hepatocytes	hepatocyte	NOUN
admet-280	303	16	,	,	PUNCT
admet-280	303	17	corroborating	corroborate	VERB
admet-280	303	18	our	our	PRON
admet-280	303	19	previous	previous	ADJ
admet-280	303	20	gene	gene	NOUN
admet-280	303	21	expression	expression	NOUN
admet-280	303	22	results	result	NOUN
admet-280	303	23	.	.	PUNCT
admet-280	304	1	expression	expression	NOUN
admet-280	304	2	of	of	ADP
admet-280	304	3	nanog	nanog	PROPN
admet-280	304	4	and	and	CCONJ
admet-280	304	5	oct4	oct4	PROPN
admet-280	304	6	in	in	ADP
admet-280	304	7	scdhs	scdhs	PROPN
admet-280	304	8	was	be	AUX
admet-280	304	9	lower	low	ADJ
admet-280	304	10	than	than	ADP
admet-280	304	11	expression	expression	NOUN
admet-280	304	12	in	in	ADP
admet-280	304	13	the	the	DET
admet-280	304	14	undifferentiated	undifferentiated	ADJ
admet-280	304	15	hesc	hesc	NOUN
admet-280	304	16	lines	line	NOUN
admet-280	304	17	and	and	CCONJ
admet-280	304	18	comparable	comparable	ADJ
admet-280	304	19	to	to	ADP
admet-280	304	20	cryopreserved	cryopreserved	ADJ
admet-280	304	21	hepatocytes	hepatocyte	NOUN
admet-280	304	22	.	.	PUNCT
admet-280	305	1	in	in	ADP
admet-280	305	2	the	the	DET
admet-280	305	3	case	case	NOUN
admet-280	305	4	of	of	ADP
admet-280	305	5	cyp2d6	cyp2d6	NOUN
admet-280	305	6	,	,	PUNCT
admet-280	305	7	expression	expression	NOUN
admet-280	305	8	levels	level	NOUN
admet-280	305	9	were	be	AUX
admet-280	305	10	detectable	detectable	ADJ
admet-280	305	11	in	in	ADP
admet-280	305	12	h9	h9	NOUN
admet-280	305	13	scdhs	scdhs	NOUN
admet-280	305	14	,	,	PUNCT
admet-280	305	15	though	though	SCONJ
admet-280	305	16	below	below	ADP
admet-280	305	17	expression	expression	NOUN
admet-280	305	18	in	in	ADP
admet-280	305	19	cryopreserved	cryopreserved	ADJ
admet-280	305	20	hepatocytes	hepatocyte	NOUN
admet-280	305	21	,	,	PUNCT
admet-280	305	22	while	while	SCONJ
admet-280	305	23	h1	h1	PROPN
admet-280	305	24	scdhs	scdhs	ADV
admet-280	305	25	were	be	AUX
admet-280	305	26	below	below	ADP
admet-280	305	27	the	the	DET
admet-280	305	28	limit	limit	NOUN
admet-280	305	29	of	of	ADP
admet-280	305	30	quantitation	quantitation	NOUN
admet-280	305	31	.	.	PUNCT
admet-280	306	1	this	this	DET
admet-280	306	2	differential	differential	ADJ
admet-280	306	3	expression	expression	NOUN
admet-280	306	4	is	be	AUX
admet-280	306	5	in	in	ADP
admet-280	306	6	line	line	NOUN
admet-280	306	7	with	with	ADP
admet-280	306	8	the	the	DET
admet-280	306	9	genotyping	genotyping	NOUN
admet-280	306	10	results	result	NOUN
admet-280	306	11	for	for	ADP
admet-280	306	12	these	these	DET
admet-280	306	13	two	two	NUM
admet-280	306	14	cell	cell	NOUN
admet-280	306	15	lines	line	NOUN
admet-280	306	16	.	.	PUNCT
admet-280	307	1	earlier	early	ADJ
admet-280	307	2	identification	identification	NOUN
admet-280	307	3	and	and	CCONJ
admet-280	307	4	characterization	characterization	NOUN
admet-280	307	5	of	of	ADP
admet-280	307	6	the	the	DET
admet-280	307	7	2988g	2988g	NUM
admet-280	307	8	>	>	PUNCT
admet-280	307	9	a	a	DET
admet-280	307	10	snp	snp	PROPN
admet-280	307	11	,	,	PUNCT
admet-280	307	12	now	now	ADV
admet-280	307	13	referred	refer	VERB
admet-280	307	14	to	to	ADP
admet-280	307	15	as	as	ADP
admet-280	307	16	cyp2d6	cyp2d6	NOUN
admet-280	307	17	*	*	SYM
admet-280	307	18	41	41	NUM
admet-280	307	19	(	(	PUNCT
admet-280	307	20	human	human	ADJ
admet-280	307	21	cyp	cyp	ADJ
admet-280	307	22	allele	allele	NOUN
admet-280	307	23	nomenclature	nomenclature	NOUN
admet-280	307	24	website	website	NOUN
admet-280	307	25	:	:	PUNCT
admet-280	307	26	http://www.imm.ki.se/	http://www.imm.ki.se/	PROPN
admet-280	307	27	)	)	PUNCT
admet-280	307	28	,	,	PUNCT
admet-280	307	29	revealed	reveal	VERB
admet-280	307	30	it	it	PRON
admet-280	307	31	to	to	PART
admet-280	307	32	cause	cause	VERB
admet-280	307	33	a	a	DET
admet-280	307	34	splicing	splicing	NOUN
admet-280	307	35	defect	defect	NOUN
admet-280	307	36	,	,	PUNCT
admet-280	307	37	resulting	result	VERB
admet-280	307	38	in	in	ADP
admet-280	307	39	exon	exon	NOUN
admet-280	307	40	6	6	NUM
admet-280	307	41	being	be	AUX
admet-280	307	42	skipped	skip	VERB
admet-280	307	43	,	,	PUNCT
admet-280	307	44	and	and	CCONJ
admet-280	307	45	a	a	DET
admet-280	307	46	predictor	predictor	NOUN
admet-280	307	47	of	of	ADP
admet-280	307	48	cyp2d6	cyp2d6	NOUN
admet-280	307	49	intermediate	intermediate	ADJ
admet-280	307	50	metabolizer	metabolizer	ADJ
admet-280	307	51	phenotype	phenotype	NOUN
admet-280	307	52	[	[	X
admet-280	307	53	54	54	NUM
admet-280	307	54	-	-	SYM
admet-280	307	55	56	56	NUM
admet-280	307	56	]	]	PUNCT
admet-280	307	57	.	.	PUNCT
admet-280	308	1	toscano	toscano	PROPN
admet-280	308	2	et	et	PROPN
admet-280	308	3	al	al	PROPN
admet-280	308	4	.	.	PROPN
admet-280	308	5	identified	identify	VERB
admet-280	308	6	the	the	DET
admet-280	308	7	splice	splice	NOUN
admet-280	308	8	variant	variant	NOUN
admet-280	308	9	lacking	lack	VERB
admet-280	308	10	exon	exon	NOUN
admet-280	308	11	6	6	NUM
admet-280	308	12	in	in	ADP
admet-280	308	13	liver	liver	NOUN
admet-280	308	14	samples	sample	NOUN
admet-280	308	15	genotyped	genotype	VERB
admet-280	308	16	for	for	ADP
admet-280	308	17	cyp2d6	cyp2d6	NOUN
admet-280	308	18	*	*	SYM
admet-280	308	19	41	41	NUM
admet-280	308	20	(	(	PUNCT
admet-280	308	21	2988g	2988g	NUM
admet-280	308	22	>	>	SYM
admet-280	308	23	a	a	NOUN
admet-280	308	24	)	)	PUNCT
admet-280	308	25	and	and	CCONJ
admet-280	308	26	found	find	VERB
admet-280	308	27	that	that	SCONJ
admet-280	308	28	2988g	2988g	NUM
admet-280	308	29	>	>	PUNCT
admet-280	308	30	a	a	DET
admet-280	308	31	causes	cause	NOUN
admet-280	308	32	favorable	favorable	ADJ
admet-280	308	33	formation	formation	NOUN
admet-280	308	34	of	of	ADP
admet-280	308	35	a	a	DET
admet-280	308	36	splice	splice	NOUN
admet-280	308	37	product	product	NOUN
admet-280	308	38	that	that	PRON
admet-280	308	39	lacks	lack	VERB
admet-280	308	40	exon	exon	NOUN
admet-280	308	41	6	6	NUM
admet-280	308	42	,	,	PUNCT
admet-280	308	43	with	with	ADP
admet-280	308	44	up	up	ADP
admet-280	308	45	to	to	PART
admet-280	308	46	7	7	NUM
admet-280	308	47	-	-	ADJ
admet-280	308	48	fold	fold	ADJ
admet-280	308	49	increased	increase	VERB
admet-280	308	50	levels	level	NOUN
admet-280	308	51	of	of	ADP
admet-280	308	52	the	the	DET
admet-280	308	53	splice	splice	NOUN
admet-280	308	54	variant	variant	NOUN
admet-280	308	55	[	[	X
admet-280	308	56	55	55	NUM
admet-280	308	57	]	]	PUNCT
admet-280	308	58	.	.	PUNCT
admet-280	309	1	we	we	PRON
admet-280	309	2	wanted	want	VERB
admet-280	309	3	to	to	PART
admet-280	309	4	further	far	ADV
admet-280	309	5	elucidate	elucidate	VERB
admet-280	309	6	the	the	DET
admet-280	309	7	penetrance	penetrance	NOUN
admet-280	309	8	of	of	ADP
admet-280	309	9	cyp2d6	cyp2d6	NOUN
admet-280	309	10	*	*	SYM
admet-280	309	11	41	41	NUM
admet-280	309	12	aberrant	aberrant	ADJ
admet-280	309	13	splicing	splicing	NOUN
admet-280	309	14	and	and	CCONJ
admet-280	309	15	,	,	PUNCT
admet-280	309	16	in	in	ADP
admet-280	309	17	addition	addition	NOUN
admet-280	309	18	,	,	PUNCT
admet-280	309	19	we	we	PRON
admet-280	309	20	wanted	want	VERB
admet-280	309	21	to	to	PART
admet-280	309	22	demonstrate	demonstrate	VERB
admet-280	309	23	the	the	DET
admet-280	309	24	potential	potential	ADJ
admet-280	309	25	utility	utility	NOUN
admet-280	309	26	of	of	ADP
admet-280	309	27	scdhs	scdhs	ADJ
admet-280	309	28	to	to	PART
admet-280	309	29	evaluate	evaluate	VERB
admet-280	309	30	genotype	genotype	NOUN
admet-280	309	31	-	-	PUNCT
admet-280	309	32	phenotype	phenotype	NOUN
admet-280	309	33	relationships	relationship	NOUN
admet-280	309	34	for	for	ADP
admet-280	309	35	cyp2d6	cyp2d6	NOUN
admet-280	309	36	.	.	PUNCT
admet-280	310	1	results	result	NOUN
admet-280	310	2	from	from	ADP
admet-280	310	3	pcr	pcr	ADJ
admet-280	310	4	amplification	amplification	NOUN
admet-280	310	5	using	use	VERB
admet-280	310	6	primers	primer	NOUN
admet-280	310	7	exon5/8for3	exon5/8for3	NOUN
admet-280	310	8	and	and	CCONJ
admet-280	310	9	exon5/8rev3	exon5/8rev3	PUNCT
admet-280	310	10	are	be	AUX
admet-280	310	11	shown	show	VERB
admet-280	310	12	in	in	ADP
admet-280	310	13	figure	figure	NOUN
admet-280	310	14	4b	4b	PROPN
admet-280	310	15	and	and	CCONJ
admet-280	310	16	c.	c.	PROPN
admet-280	310	17	the	the	DET
admet-280	310	18	expected	expect	VERB
admet-280	310	19	amplicons	amplicon	NOUN
admet-280	310	20	for	for	ADP
admet-280	310	21	samples	sample	NOUN
admet-280	310	22	homozygous	homozygous	ADJ
admet-280	310	23	for	for	ADP
admet-280	310	24	cyp2d6	cyp2d6	NOUN
admet-280	310	25	*	*	SYM
admet-280	310	26	41	41	NUM
admet-280	310	27	are	be	AUX
admet-280	310	28	438	438	NUM
admet-280	310	29	-	-	PUNCT
admet-280	310	30	bp	bp	NOUN
admet-280	310	31	,	,	PUNCT
admet-280	310	32	for	for	ADP
admet-280	310	33	heterozygous	heterozygous	ADJ
admet-280	310	34	samples	sample	NOUN
admet-280	310	35	both	both	CCONJ
admet-280	310	36	438	438	NUM
admet-280	310	37	-	-	PUNCT
admet-280	310	38	bp	bp	NOUN
admet-280	310	39	and	and	CCONJ
admet-280	310	40	579	579	NUM
admet-280	310	41	-	-	PUNCT
admet-280	310	42	bp	bp	NOUN
admet-280	310	43	,	,	PUNCT
admet-280	310	44	and	and	CCONJ
admet-280	310	45	for	for	ADP
admet-280	310	46	non	non	NOUN
admet-280	310	47	-	-	NOUN
admet-280	310	48	carriers	carrier	NOUN
admet-280	310	49	of	of	ADP
admet-280	310	50	cyp2d6	cyp2d6	NOUN
admet-280	310	51	*	*	PROPN
admet-280	310	52	41	41	NUM
admet-280	310	53	579	579	NUM
admet-280	310	54	-	-	PUNCT
admet-280	310	55	bp	bp	NOUN
admet-280	310	56	.	.	PUNCT
admet-280	311	1	as	as	SCONJ
admet-280	311	2	shown	show	VERB
admet-280	311	3	in	in	ADP
admet-280	311	4	figure	figure	NOUN
admet-280	311	5	4c	4c	NOUN
admet-280	311	6	,	,	PUNCT
admet-280	311	7	certain	certain	ADJ
admet-280	311	8	samples	sample	NOUN
admet-280	311	9	(	(	PUNCT
admet-280	311	10	lanes	lane	NOUN
admet-280	311	11	1	1	NUM
admet-280	311	12	and	and	CCONJ
admet-280	311	13	2	2	NUM
admet-280	311	14	)	)	PUNCT
admet-280	311	15	homozygous	homozygous	ADJ
admet-280	311	16	for	for	ADP
admet-280	311	17	*	*	PROPN
admet-280	311	18	41	41	NUM
admet-280	311	19	have	have	VERB
admet-280	311	20	a	a	DET
admet-280	311	21	579bp	579bp	NOUN
admet-280	311	22	amplicon	amplicon	NOUN
admet-280	311	23	as	as	ADV
admet-280	311	24	well	well	ADV
admet-280	311	25	as	as	ADP
admet-280	311	26	the	the	DET
admet-280	311	27	expected	expected	ADJ
admet-280	311	28	438	438	NUM
admet-280	311	29	-	-	PUNCT
admet-280	311	30	bp	bp	NOUN
admet-280	311	31	alternatively	alternatively	ADV
admet-280	311	32	spliced	splice	VERB
admet-280	311	33	band	band	NOUN
admet-280	311	34	,	,	PUNCT
admet-280	311	35	indicating	indicate	VERB
admet-280	311	36	the	the	DET
admet-280	311	37	unexpected	unexpected	ADJ
admet-280	311	38	presence	presence	NOUN
admet-280	311	39	of	of	ADP
admet-280	311	40	exon	exon	NOUN
admet-280	311	41	6	6	NUM
admet-280	311	42	,	,	PUNCT
admet-280	311	43	and	and	CCONJ
admet-280	311	44	demonstrating	demonstrate	VERB
admet-280	311	45	incomplete	incomplete	ADJ
admet-280	311	46	penetrance	penetrance	NOUN
admet-280	311	47	of	of	ADP
admet-280	311	48	this	this	DET
admet-280	311	49	splicing	splicing	NOUN
admet-280	311	50	defect	defect	NOUN
admet-280	311	51	.	.	PUNCT
admet-280	312	1	in	in	ADP
admet-280	312	2	addition	addition	NOUN
admet-280	312	3	,	,	PUNCT
admet-280	312	4	one	one	NUM
admet-280	312	5	sample	sample	NOUN
admet-280	312	6	(	(	PUNCT
admet-280	312	7	lane	lane	NOUN
admet-280	312	8	7	7	NUM
admet-280	312	9	)	)	PUNCT
admet-280	312	10	heterozygous	heterozygous	ADJ
admet-280	312	11	for	for	ADP
admet-280	312	12	*	*	NOUN
admet-280	312	13	41	41	NUM
admet-280	312	14	only	only	ADV
admet-280	312	15	displays	display	VERB
admet-280	312	16	the	the	DET
admet-280	312	17	579	579	NUM
admet-280	312	18	-	-	PUNCT
admet-280	312	19	bp	bp	NOUN
admet-280	312	20	amplicon	amplicon	NOUN
admet-280	312	21	,	,	PUNCT
admet-280	312	22	indicating	indicate	VERB
admet-280	312	23	presence	presence	NOUN
admet-280	312	24	of	of	ADP
admet-280	312	25	exon	exon	NOUN
admet-280	312	26	6	6	NUM
admet-280	312	27	in	in	ADP
admet-280	312	28	all	all	PRON
admet-280	312	29	mrna	mrna	PROPN
admet-280	312	30	produced	produce	VERB
admet-280	312	31	(	(	PUNCT
admet-280	312	32	or	or	CCONJ
admet-280	312	33	suppression	suppression	NOUN
admet-280	312	34	of	of	ADP
admet-280	312	35	expression	expression	NOUN
admet-280	312	36	of	of	ADP
admet-280	312	37	the	the	DET
admet-280	312	38	*	*	ADJ
admet-280	312	39	41	41	NUM
admet-280	312	40	allele	allele	NOUN
admet-280	312	41	)	)	PUNCT
admet-280	312	42	.	.	PUNCT
admet-280	313	1	it	it	PRON
admet-280	313	2	should	should	AUX
admet-280	313	3	be	be	AUX
admet-280	313	4	noted	note	VERB
admet-280	313	5	that	that	SCONJ
admet-280	313	6	the	the	DET
admet-280	313	7	aberrantly	aberrantly	ADV
admet-280	313	8	spliced	splice	VERB
admet-280	313	9	band	band	NOUN
admet-280	313	10	may	may	AUX
admet-280	313	11	be	be	AUX
admet-280	313	12	present	present	ADJ
admet-280	313	13	,	,	PUNCT
admet-280	313	14	but	but	CCONJ
admet-280	313	15	simply	simply	ADV
admet-280	313	16	was	be	AUX
admet-280	313	17	below	below	ADP
admet-280	313	18	the	the	DET
admet-280	313	19	limit	limit	NOUN
admet-280	313	20	of	of	ADP
admet-280	313	21	detection	detection	NOUN
admet-280	313	22	in	in	ADP
admet-280	313	23	our	our	PRON
admet-280	313	24	rt	rt	NOUN
admet-280	313	25	-	-	PUNCT
admet-280	313	26	pcr	pcr	NOUN
admet-280	313	27	assay	assay	NOUN
admet-280	313	28	.	.	PUNCT
admet-280	314	1	the	the	DET
admet-280	314	2	h1	h1	PROPN
admet-280	314	3	scdh	scdh	VERB
admet-280	314	4	sample	sample	NOUN
admet-280	314	5	,	,	PUNCT
admet-280	314	6	with	with	ADP
admet-280	314	7	one	one	NUM
admet-280	314	8	copy	copy	NOUN
admet-280	314	9	of	of	ADP
admet-280	314	10	cyp2d6	cyp2d6	NOUN
admet-280	314	11	containing	contain	VERB
admet-280	314	12	*	*	PROPN
admet-280	314	13	41	41	NUM
admet-280	314	14	displays	display	NOUN
admet-280	314	15	the	the	DET
admet-280	314	16	expected	expect	VERB
admet-280	314	17	exon	exon	NOUN
admet-280	314	18	6	6	NUM
admet-280	314	19	spliced	splice	VERB
admet-280	314	20	band	band	NOUN
admet-280	314	21	at	at	ADP
admet-280	314	22	438	438	NUM
admet-280	314	23	-	-	PUNCT
admet-280	314	24	bp	bp	NOUN
admet-280	314	25	,	,	PUNCT
admet-280	314	26	as	as	SCONJ
admet-280	314	27	seen	see	VERB
admet-280	314	28	in	in	ADP
admet-280	314	29	figure	figure	NOUN
admet-280	314	30	4c	4c	NOUN
admet-280	314	31	,	,	PUNCT
admet-280	314	32	lane	lane	NOUN
admet-280	314	33	13	13	NUM
admet-280	314	34	.	.	PUNCT
admet-280	315	1	no	no	DET
admet-280	315	2	properly	properly	ADV
admet-280	315	3	spliced	splice	VERB
admet-280	315	4	band	band	NOUN
admet-280	315	5	was	be	AUX
admet-280	315	6	detected	detect	VERB
admet-280	315	7	,	,	PUNCT
admet-280	315	8	as	as	SCONJ
admet-280	315	9	expected	expect	VERB
admet-280	315	10	.	.	PUNCT
admet-280	316	1	our	our	PRON
admet-280	316	2	scdh	scdh	NOUN
admet-280	316	3	cyp2d6	cyp2d6	NOUN
admet-280	316	4	*	*	SYM
admet-280	316	5	41	41	NUM
admet-280	316	6	http://www.imm.ki.se/	http://www.imm.ki.se/	PROPN
admet-280	316	7	admet	admet	PROPN
admet-280	316	8	&	&	CCONJ
admet-280	316	9	dmpk	dmpk	PROPN
admet-280	316	10	4(2	4(2	NUM
admet-280	316	11	)	)	PUNCT
admet-280	316	12	(	(	PUNCT
admet-280	316	13	2016	2016	NUM
admet-280	316	14	)	)	PUNCT
admet-280	316	15	62	62	NUM
admet-280	316	16	-	-	SYM
admet-280	316	17	83	83	NUM
admet-280	316	18	pharmacogenetics	pharmacogenetic	NOUN
admet-280	316	19	and	and	CCONJ
admet-280	316	20	cyp	cyp	ADJ
admet-280	316	21	activity	activity	NOUN
admet-280	316	22	doi	doi	NOUN
admet-280	316	23	:	:	PUNCT
admet-280	316	24	10.5599	10.5599	NUM
admet-280	316	25	/	/	SYM
admet-280	316	26	admet.4.2.280	admet.4.2.280	VERB
admet-280	316	27	77	77	NUM
admet-280	316	28	heterozygous	heterozygous	ADJ
admet-280	316	29	cell	cell	NOUN
admet-280	316	30	,	,	PUNCT
admet-280	316	31	line	line	NOUN
admet-280	316	32	h9	h9	NOUN
admet-280	316	33	(	(	PUNCT
admet-280	316	34	lane	lane	NOUN
admet-280	316	35	14	14	NUM
admet-280	316	36	)	)	PUNCT
admet-280	316	37	also	also	ADV
admet-280	316	38	displays	display	VERB
admet-280	316	39	a	a	DET
admet-280	316	40	band	band	NOUN
admet-280	316	41	indicating	indicate	VERB
admet-280	316	42	aberrant	aberrant	ADJ
admet-280	316	43	exon	exon	NOUN
admet-280	316	44	6	6	NUM
admet-280	316	45	splicing	splicing	NOUN
admet-280	316	46	,	,	PUNCT
admet-280	316	47	but	but	CCONJ
admet-280	316	48	only	only	ADV
admet-280	316	49	a	a	DET
admet-280	316	50	weak	weak	ADJ
admet-280	316	51	band	band	NOUN
admet-280	316	52	for	for	ADP
admet-280	316	53	the	the	DET
admet-280	316	54	properly	properly	ADV
admet-280	316	55	spliced	splice	VERB
admet-280	316	56	transcript	transcript	NOUN
admet-280	316	57	fragment	fragment	NOUN
admet-280	316	58	.	.	PUNCT
admet-280	317	1	again	again	ADV
admet-280	317	2	,	,	PUNCT
admet-280	317	3	bands	band	NOUN
admet-280	317	4	may	may	AUX
admet-280	317	5	be	be	AUX
admet-280	317	6	present	present	ADJ
admet-280	317	7	,	,	PUNCT
admet-280	317	8	but	but	CCONJ
admet-280	317	9	simply	simply	ADV
admet-280	317	10	were	be	AUX
admet-280	317	11	below	below	ADP
admet-280	317	12	the	the	DET
admet-280	317	13	limit	limit	NOUN
admet-280	317	14	of	of	ADP
admet-280	317	15	detection	detection	NOUN
admet-280	317	16	in	in	ADP
admet-280	317	17	our	our	PRON
admet-280	317	18	rt	rt	NOUN
admet-280	317	19	-	-	PUNCT
admet-280	317	20	pcr	pcr	NOUN
admet-280	317	21	assay	assay	NOUN
admet-280	317	22	;	;	PUNCT
admet-280	317	23	based	base	VERB
admet-280	317	24	on	on	ADP
admet-280	317	25	observations	observation	NOUN
admet-280	317	26	from	from	ADP
admet-280	317	27	the	the	DET
admet-280	317	28	qrt	qrt	NOUN
admet-280	317	29	-	-	PUNCT
admet-280	317	30	pcr	pcr	NOUN
admet-280	317	31	that	that	PRON
admet-280	317	32	cyp2d6	cyp2d6	NOUN
admet-280	317	33	expression	expression	NOUN
admet-280	317	34	in	in	ADP
admet-280	317	35	h1	h1	PROPN
admet-280	317	36	scdhs	scdhs	PROPN
admet-280	317	37	is	be	AUX
admet-280	317	38	below	below	ADP
admet-280	317	39	the	the	DET
admet-280	317	40	limit	limit	NOUN
admet-280	317	41	of	of	ADP
admet-280	317	42	quantitation	quantitation	NOUN
admet-280	317	43	and	and	CCONJ
admet-280	317	44	in	in	ADP
admet-280	317	45	h9	h9	NOUN
admet-280	317	46	scdhs	scdhs	PROPN
admet-280	317	47	is	be	AUX
admet-280	317	48	16	16	NUM
admet-280	317	49	fold	fold	ADV
admet-280	317	50	lower	low	ADJ
admet-280	317	51	than	than	ADP
admet-280	317	52	that	that	PRON
admet-280	317	53	of	of	ADP
admet-280	317	54	cryopreserved	cryopreserved	ADJ
admet-280	317	55	hepatocytes	hepatocyte	NOUN
admet-280	317	56	based	base	VERB
admet-280	317	57	on	on	ADP
admet-280	317	58	∆∆ct	∆∆ct	NOUN
admet-280	317	59	calculations	calculation	NOUN
admet-280	317	60	.	.	PUNCT
admet-280	318	1	we	we	PRON
admet-280	318	2	are	be	AUX
admet-280	318	3	able	able	ADJ
admet-280	318	4	to	to	PART
admet-280	318	5	show	show	VERB
admet-280	318	6	similar	similar	ADJ
admet-280	318	7	results	result	NOUN
admet-280	318	8	for	for	ADP
admet-280	318	9	cyp2d6	cyp2d6	NOUN
admet-280	318	10	*	*	SYM
admet-280	318	11	41	41	NUM
admet-280	318	12	splicing	splicing	NOUN
admet-280	318	13	in	in	ADP
admet-280	318	14	our	our	PRON
admet-280	318	15	scdhs	scdhs	NOUN
admet-280	318	16	as	as	SCONJ
admet-280	318	17	seen	see	VERB
admet-280	318	18	in	in	ADP
admet-280	318	19	the	the	DET
admet-280	318	20	liver	liver	NOUN
admet-280	318	21	tissue	tissue	NOUN
admet-280	318	22	samples	sample	NOUN
admet-280	318	23	.	.	PUNCT
admet-280	319	1	overall	overall	ADV
admet-280	319	2	,	,	PUNCT
admet-280	319	3	our	our	PRON
admet-280	319	4	results	result	NOUN
admet-280	319	5	corroborate	corroborate	VERB
admet-280	319	6	the	the	DET
admet-280	319	7	findings	finding	NOUN
admet-280	319	8	of	of	ADP
admet-280	319	9	toscano	toscano	PROPN
admet-280	319	10	et	et	PROPN
admet-280	319	11	al	al	PROPN
admet-280	319	12	.	.	PUNCT
admet-280	319	13	and	and	CCONJ
admet-280	319	14	provide	provide	VERB
admet-280	319	15	further	further	ADJ
admet-280	319	16	evidence	evidence	NOUN
admet-280	319	17	that	that	SCONJ
admet-280	319	18	cyp2d6	cyp2d6	NOUN
admet-280	319	19	*	*	SYM
admet-280	319	20	41	41	NUM
admet-280	319	21	displays	display	NOUN
admet-280	319	22	incomplete	incomplete	ADJ
admet-280	319	23	penetrance	penetrance	NOUN
admet-280	319	24	.	.	PUNCT
admet-280	320	1	figure	figure	NOUN
admet-280	320	2	4	4	NUM
admet-280	320	3	.	.	PUNCT
admet-280	321	1	cyp2d6	cyp2d6	NOUN
admet-280	321	2	*	*	SYM
admet-280	321	3	41	41	NUM
admet-280	321	4	reverse	reverse	ADJ
admet-280	321	5	transcription	transcription	NOUN
admet-280	321	6	pcr	pcr	NOUN
admet-280	321	7	assay	assay	VERB
admet-280	321	8	.	.	PUNCT
admet-280	322	1	(	(	PUNCT
admet-280	322	2	a	a	X
admet-280	322	3	)	)	PUNCT
admet-280	322	4	gene	gene	NOUN
admet-280	322	5	expression	expression	NOUN
admet-280	322	6	results	result	NOUN
admet-280	322	7	shown	show	VERB
admet-280	322	8	as	as	ADP
admet-280	322	9	fold	fold	ADJ
admet-280	322	10	change	change	NOUN
admet-280	322	11	compared	compare	VERB
admet-280	322	12	to	to	ADP
admet-280	322	13	cryopreserved	cryopreserve	VERB
admet-280	322	14	hepatocyte	hepatocyte	NOUN
admet-280	322	15	lot	lot	NOUN
admet-280	322	16	hum4012	hum4012	NOUN
admet-280	322	17	,	,	PUNCT
admet-280	322	18	which	which	PRON
admet-280	322	19	was	be	AUX
admet-280	322	20	set	set	VERB
admet-280	322	21	to	to	ADP
admet-280	322	22	1	1	NUM
admet-280	322	23	.	.	PUNCT
admet-280	323	1	(	(	PUNCT
admet-280	323	2	b	b	X
admet-280	323	3	)	)	PUNCT
admet-280	323	4	schematic	schematic	ADJ
admet-280	323	5	representation	representation	NOUN
admet-280	323	6	of	of	ADP
admet-280	323	7	the	the	DET
admet-280	323	8	cyp2d6	cyp2d6	NOUN
admet-280	323	9	gene	gene	NOUN
admet-280	323	10	.	.	PUNCT
admet-280	324	1	the	the	DET
admet-280	324	2	polymorphism	polymorphism	NOUN
admet-280	324	3	of	of	ADP
admet-280	324	4	interest	interest	NOUN
admet-280	324	5	is	be	AUX
admet-280	324	6	2988g	2988g	NUM
admet-280	324	7	>	>	X
admet-280	324	8	a	a	DET
admet-280	324	9	located	locate	VERB
admet-280	324	10	between	between	ADP
admet-280	324	11	exons	exon	NOUN
admet-280	324	12	6	6	NUM
admet-280	324	13	and	and	CCONJ
admet-280	324	14	7	7	NUM
admet-280	324	15	,	,	PUNCT
admet-280	324	16	and	and	CCONJ
admet-280	324	17	results	result	NOUN
admet-280	324	18	in	in	ADP
admet-280	324	19	exon	exon	NOUN
admet-280	324	20	6	6	NUM
admet-280	324	21	skipping	skip	VERB
admet-280	324	22	.	.	PUNCT
admet-280	325	1	to	to	PART
admet-280	325	2	detect	detect	VERB
admet-280	325	3	the	the	DET
admet-280	325	4	presence	presence	NOUN
admet-280	325	5	of	of	ADP
admet-280	325	6	exon	exon	NOUN
admet-280	325	7	6	6	NUM
admet-280	325	8	in	in	ADP
admet-280	325	9	cyp2d6	cyp2d6	NOUN
admet-280	325	10	,	,	PUNCT
admet-280	325	11	a	a	DET
admet-280	325	12	579	579	NUM
admet-280	325	13	-	-	PUNCT
admet-280	325	14	bp	bp	NOUN
admet-280	325	15	pcr	pcr	ADJ
admet-280	325	16	fragment	fragment	NOUN
admet-280	325	17	spanning	span	VERB
admet-280	325	18	a	a	DET
admet-280	325	19	region	region	NOUN
admet-280	325	20	from	from	ADP
admet-280	325	21	exon	exon	NOUN
admet-280	325	22	5	5	NUM
admet-280	325	23	to	to	PART
admet-280	325	24	exon	exon	NOUN
admet-280	325	25	8	8	NUM
admet-280	325	26	was	be	AUX
admet-280	325	27	amplified	amplify	VERB
admet-280	325	28	with	with	ADP
admet-280	325	29	primers	primer	NOUN
admet-280	325	30	exon5/8for3	exon5/8for3	X
admet-280	326	1	(	(	PUNCT
admet-280	326	2	f	f	PROPN
admet-280	326	3	primer	primer	NOUN
admet-280	326	4	)	)	PUNCT
admet-280	326	5	and	and	CCONJ
admet-280	326	6	exon5/8rev3	exon5/8rev3	X
admet-280	326	7	(	(	PUNCT
admet-280	326	8	r	r	NOUN
admet-280	326	9	primer	primer	NOUN
admet-280	326	10	)	)	PUNCT
admet-280	326	11	.	.	PUNCT
admet-280	327	1	if	if	SCONJ
admet-280	327	2	exon	exon	NOUN
admet-280	327	3	6	6	NUM
admet-280	327	4	is	be	AUX
admet-280	327	5	skipped	skip	VERB
admet-280	327	6	due	due	ADJ
admet-280	327	7	to	to	ADP
admet-280	327	8	the	the	DET
admet-280	327	9	presence	presence	NOUN
admet-280	327	10	of	of	ADP
admet-280	327	11	cyp2d6	cyp2d6	PROPN
admet-280	327	12	*	*	SYM
admet-280	327	13	41	41	NUM
admet-280	327	14	,	,	PUNCT
admet-280	327	15	a	a	DET
admet-280	327	16	smaller	small	ADJ
admet-280	327	17	pcr	pcr	ADJ
admet-280	327	18	fragment	fragment	NOUN
admet-280	327	19	of	of	ADP
admet-280	327	20	438	438	NUM
admet-280	327	21	-	-	PUNCT
admet-280	327	22	bp	bp	PROPN
admet-280	327	23	is	be	AUX
admet-280	327	24	expected	expect	VERB
admet-280	327	25	.	.	PUNCT
admet-280	328	1	(	(	PUNCT
admet-280	328	2	c	c	X
admet-280	328	3	)	)	PUNCT
admet-280	328	4	agarose	agarose	NOUN
admet-280	328	5	electrophoretic	electrophoretic	ADJ
admet-280	328	6	analysis	analysis	NOUN
admet-280	328	7	of	of	ADP
admet-280	328	8	reverse	reverse	ADJ
admet-280	328	9	transcription	transcription	NOUN
admet-280	328	10	pcr	pcr	NOUN
admet-280	328	11	products	product	NOUN
admet-280	328	12	of	of	ADP
admet-280	328	13	the	the	DET
admet-280	328	14	cyp2d6	cyp2d6	NOUN
admet-280	328	15	region	region	NOUN
admet-280	328	16	indicated	indicate	VERB
admet-280	328	17	in	in	ADP
admet-280	328	18	(	(	PUNCT
admet-280	328	19	b	b	NOUN
admet-280	328	20	)	)	PUNCT
admet-280	328	21	from	from	ADP
admet-280	328	22	human	human	ADJ
admet-280	328	23	liver	liver	NOUN
admet-280	328	24	tissue	tissue	NOUN
admet-280	328	25	samples	sample	NOUN
admet-280	328	26	and	and	CCONJ
admet-280	328	27	day	day	NOUN
admet-280	328	28	17	17	NUM
admet-280	328	29	scdhs	scdhs	NOUN
admet-280	328	30	generated	generate	VERB
admet-280	328	31	from	from	ADP
admet-280	328	32	wicell	wicell	PROPN
admet-280	328	33	®	®	NOUN
admet-280	328	34	lines	line	NOUN
admet-280	328	35	h1	h1	VERB
admet-280	328	36	and	and	CCONJ
admet-280	328	37	h9	h9	NOUN
admet-280	328	38	.	.	PUNCT
admet-280	329	1	lane	lane	PROPN
admet-280	329	2	m	m	PROPN
admet-280	329	3	,	,	PUNCT
admet-280	329	4	100bp	100bp	ADJ
admet-280	329	5	marker	marker	NOUN
admet-280	329	6	;	;	PUNCT
admet-280	329	7	lane	lane	NOUN
admet-280	329	8	1	1	NUM
admet-280	329	9	*	*	SYM
admet-280	329	10	41/*41	41/*41	NOUN
admet-280	329	11	;	;	PUNCT
admet-280	329	12	lane	lane	NOUN
admet-280	329	13	2	2	NUM
admet-280	329	14	*	*	SYM
admet-280	329	15	41/*41	41/*41	NUM
admet-280	329	16	;	;	PUNCT
admet-280	329	17	lane	lane	NOUN
admet-280	329	18	3	3	NUM
admet-280	329	19	*	*	SYM
admet-280	329	20	1a/*1a	1a/*1a	NUM
admet-280	329	21	;	;	PUNCT
admet-280	329	22	lane	lane	NOUN
admet-280	329	23	4	4	NUM
admet-280	329	24	*	*	NOUN
admet-280	329	25	1a/*1a	1a/*1a	NUM
admet-280	329	26	;	;	PUNCT
admet-280	329	27	lane	lane	NOUN
admet-280	329	28	5	5	NUM
admet-280	329	29	*	*	PUNCT
admet-280	329	30	2a/*2a	2a/*2a	NUM
admet-280	329	31	;	;	PUNCT
admet-280	329	32	lane	lane	NOUN
admet-280	329	33	6	6	NUM
admet-280	329	34	*	*	NOUN
admet-280	329	35	1a/*1a	1a/*1a	NUM
admet-280	329	36	;	;	PUNCT
admet-280	329	37	lane	lane	NOUN
admet-280	329	38	7	7	NUM
admet-280	329	39	*	*	SYM
admet-280	329	40	1a/*41	1a/*41	NUM
admet-280	329	41	;	;	PUNCT
admet-280	329	42	lane	lane	NOUN
admet-280	329	43	8	8	NUM
admet-280	329	44	*	*	SYM
admet-280	329	45	4a/*41	4a/*41	NUM
admet-280	329	46	;	;	PUNCT
admet-280	329	47	lane	lane	NOUN
admet-280	329	48	9	9	NUM
admet-280	329	49	*	*	SYM
admet-280	329	50	1a/*41	1a/*41	NUM
admet-280	329	51	;	;	PUNCT
admet-280	329	52	lane	lane	NOUN
admet-280	329	53	10	10	NUM
admet-280	329	54	*	*	SYM
admet-280	329	55	2a/*41	2a/*41	NUM
admet-280	329	56	;	;	PUNCT
admet-280	329	57	lane	lane	NOUN
admet-280	329	58	11	11	NUM
admet-280	329	59	*	*	SYM
admet-280	329	60	2a/*41	2a/*41	NUM
admet-280	329	61	;	;	PUNCT
admet-280	329	62	lane	lane	NOUN
admet-280	329	63	12	12	NUM
admet-280	329	64	*	*	NOUN
admet-280	329	65	9a/*41	9a/*41	NUM
admet-280	329	66	;	;	PUNCT
admet-280	329	67	lane	lane	NOUN
admet-280	329	68	13	13	NUM
admet-280	329	69	h1	h1	NOUN
admet-280	329	70	*	*	PROPN
admet-280	329	71	41	41	NUM
admet-280	329	72	;	;	PUNCT
admet-280	329	73	lane	lane	PROPN
admet-280	329	74	14	14	NUM
admet-280	329	75	h9	h9	PROPN
admet-280	329	76	*	*	PUNCT
admet-280	329	77	41	41	NUM
admet-280	329	78	carrier	carrier	NOUN
admet-280	329	79	.	.	PUNCT
admet-280	330	1	voellinger	voellinger	VERB
admet-280	330	2	and	and	CCONJ
admet-280	330	3	kelly	kelly	PROPN
admet-280	330	4	admet	admet	PROPN
admet-280	330	5	&	&	CCONJ
admet-280	330	6	dmpk	dmpk	PROPN
admet-280	330	7	4(2	4(2	NUM
admet-280	330	8	)	)	PUNCT
admet-280	330	9	(	(	PUNCT
admet-280	330	10	2016	2016	NUM
admet-280	330	11	)	)	PUNCT
admet-280	330	12	62	62	NUM
admet-280	330	13	-	-	SYM
admet-280	330	14	83	83	NUM
admet-280	330	15	78	78	NUM
admet-280	330	16	conclusions	conclusion	NOUN
admet-280	330	17	pluripotent	pluripotent	ADJ
admet-280	330	18	stem	stem	NOUN
admet-280	330	19	cells	cell	NOUN
admet-280	330	20	have	have	VERB
admet-280	330	21	a	a	DET
admet-280	330	22	high	high	ADJ
admet-280	330	23	self	self	NOUN
admet-280	330	24	-	-	PUNCT
admet-280	330	25	renewal	renewal	NOUN
admet-280	330	26	capability	capability	NOUN
admet-280	330	27	and	and	CCONJ
admet-280	330	28	can	can	AUX
admet-280	330	29	differentiate	differentiate	VERB
admet-280	330	30	into	into	ADP
admet-280	330	31	any	any	DET
admet-280	330	32	cell	cell	NOUN
admet-280	330	33	type	type	NOUN
admet-280	330	34	in	in	ADP
admet-280	330	35	the	the	DET
admet-280	330	36	body	body	NOUN
admet-280	330	37	,	,	PUNCT
admet-280	330	38	making	make	VERB
admet-280	330	39	them	they	PRON
admet-280	330	40	an	an	DET
admet-280	330	41	attractive	attractive	ADJ
admet-280	330	42	tool	tool	NOUN
admet-280	330	43	for	for	ADP
admet-280	330	44	researchers	researcher	NOUN
admet-280	330	45	in	in	ADP
admet-280	330	46	drug	drug	NOUN
admet-280	330	47	discovery	discovery	NOUN
admet-280	330	48	and	and	CCONJ
admet-280	330	49	development	development	NOUN
admet-280	330	50	.	.	PUNCT
admet-280	331	1	scdhs	scdhs	PROPN
admet-280	331	2	offer	offer	VERB
admet-280	331	3	a	a	DET
admet-280	331	4	promising	promising	ADJ
admet-280	331	5	new	new	ADJ
admet-280	331	6	tool	tool	NOUN
admet-280	331	7	for	for	ADP
admet-280	331	8	use	use	NOUN
admet-280	331	9	in	in	ADP
admet-280	331	10	hepatic	hepatic	ADJ
admet-280	331	11	drug	drug	NOUN
admet-280	331	12	metabolism	metabolism	NOUN
admet-280	331	13	and	and	CCONJ
admet-280	331	14	toxicity	toxicity	NOUN
admet-280	331	15	screens	screen	NOUN
admet-280	331	16	,	,	PUNCT
admet-280	331	17	adding	add	VERB
admet-280	331	18	to	to	AUX
admet-280	331	19	available	available	VERB
admet-280	331	20	human	human	ADJ
admet-280	331	21	derived	derive	VERB
admet-280	331	22	cell	cell	NOUN
admet-280	331	23	models	model	NOUN
admet-280	331	24	.	.	PUNCT
admet-280	332	1	there	there	PRON
admet-280	332	2	has	have	AUX
admet-280	332	3	been	be	AUX
admet-280	332	4	extensive	extensive	ADJ
admet-280	332	5	research	research	NOUN
admet-280	332	6	on	on	ADP
admet-280	332	7	scdhs	scdhs	ADJ
admet-280	332	8	for	for	ADP
admet-280	332	9	this	this	DET
admet-280	332	10	purpose	purpose	NOUN
admet-280	332	11	,	,	PUNCT
admet-280	332	12	and	and	CCONJ
admet-280	332	13	while	while	SCONJ
admet-280	332	14	there	there	PRON
admet-280	332	15	is	be	VERB
admet-280	332	16	evidence	evidence	NOUN
admet-280	332	17	scdhs	scdhs	ADJ
admet-280	332	18	express	express	VERB
admet-280	332	19	drug	drug	NOUN
admet-280	332	20	-	-	PUNCT
admet-280	332	21	metabolizing	metabolize	VERB
admet-280	332	22	enzymes	enzyme	NOUN
admet-280	332	23	,	,	PUNCT
admet-280	332	24	they	they	PRON
admet-280	332	25	remain	remain	VERB
admet-280	332	26	in	in	ADP
admet-280	332	27	a	a	DET
admet-280	332	28	de	de	ADJ
admet-280	332	29	-	-	ADJ
admet-280	332	30	differentiated	differentiated	ADJ
admet-280	332	31	state	state	NOUN
admet-280	332	32	.	.	PUNCT
admet-280	333	1	this	this	PRON
admet-280	333	2	indicates	indicate	VERB
admet-280	333	3	there	there	PRON
admet-280	333	4	is	be	VERB
admet-280	333	5	a	a	DET
admet-280	333	6	significant	significant	ADJ
admet-280	333	7	need	need	NOUN
admet-280	333	8	for	for	ADP
admet-280	333	9	improvement	improvement	NOUN
admet-280	333	10	on	on	ADP
admet-280	333	11	generating	generate	VERB
admet-280	333	12	and	and	CCONJ
admet-280	333	13	characterizing	characterize	VERB
admet-280	333	14	scdhs	scdhs	NOUN
admet-280	333	15	,	,	PUNCT
admet-280	333	16	particularly	particularly	ADV
admet-280	333	17	with	with	ADP
admet-280	333	18	regards	regard	NOUN
admet-280	333	19	to	to	ADP
admet-280	333	20	their	their	PRON
admet-280	333	21	metabolic	metabolic	NOUN
admet-280	333	22	capacity	capacity	NOUN
admet-280	333	23	as	as	SCONJ
admet-280	333	24	it	it	PRON
admet-280	333	25	compares	compare	VERB
admet-280	333	26	to	to	ADP
admet-280	333	27	primary	primary	ADJ
admet-280	333	28	hepatocytes	hepatocyte	NOUN
admet-280	333	29	.	.	PUNCT
admet-280	334	1	in	in	ADP
admet-280	334	2	this	this	DET
admet-280	334	3	study	study	NOUN
admet-280	334	4	,	,	PUNCT
admet-280	334	5	gene	gene	NOUN
admet-280	334	6	expression	expression	NOUN
admet-280	334	7	profiling	profiling	NOUN
admet-280	334	8	and	and	CCONJ
admet-280	334	9	functional	functional	ADJ
admet-280	334	10	assays	assay	NOUN
admet-280	334	11	of	of	ADP
admet-280	334	12	cyp	cyp	ADJ
admet-280	334	13	activity	activity	NOUN
admet-280	334	14	indicate	indicate	VERB
admet-280	334	15	scdhs	scdhs	ADJ
admet-280	334	16	are	be	AUX
admet-280	334	17	largely	largely	ADV
admet-280	334	18	immature	immature	ADJ
admet-280	334	19	hepatocytes	hepatocyte	NOUN
admet-280	334	20	,	,	PUNCT
admet-280	334	21	lacking	lack	VERB
admet-280	334	22	significant	significant	ADJ
admet-280	334	23	cyp	cyp	ADJ
admet-280	334	24	expression	expression	NOUN
admet-280	334	25	and	and	CCONJ
admet-280	334	26	activity	activity	NOUN
admet-280	334	27	.	.	PUNCT
admet-280	335	1	based	base	VERB
admet-280	335	2	on	on	ADP
admet-280	335	3	gene	gene	NOUN
admet-280	335	4	expression	expression	NOUN
admet-280	335	5	profiling	profiling	NOUN
admet-280	335	6	,	,	PUNCT
admet-280	335	7	scdhs	scdhs	VERB
admet-280	335	8	most	most	ADV
admet-280	335	9	closely	closely	ADV
admet-280	335	10	resemble	resemble	VERB
admet-280	335	11	fetal	fetal	ADJ
admet-280	335	12	hepatocytes	hepatocyte	NOUN
admet-280	335	13	,	,	PUNCT
admet-280	335	14	especially	especially	ADV
admet-280	335	15	with	with	ADP
admet-280	335	16	regards	regard	NOUN
admet-280	335	17	to	to	ADP
admet-280	335	18	afp	afp	PROPN
admet-280	335	19	,	,	PUNCT
admet-280	335	20	cyp3a7	cyp3a7	NOUN
admet-280	335	21	and	and	CCONJ
admet-280	335	22	fmo1	fmo1	NOUN
admet-280	335	23	expression	expression	NOUN
admet-280	335	24	.	.	PUNCT
admet-280	336	1	functional	functional	ADJ
admet-280	336	2	assay	assay	NOUN
admet-280	336	3	of	of	ADP
admet-280	336	4	enzyme	enzyme	NOUN
admet-280	336	5	activity	activity	NOUN
admet-280	336	6	in	in	ADP
admet-280	336	7	scdhs	scdhs	ADJ
admet-280	336	8	using	use	VERB
admet-280	336	9	a	a	DET
admet-280	336	10	cyp	cyp	ADJ
admet-280	336	11	cocktail	cocktail	NOUN
admet-280	336	12	revealed	reveal	VERB
admet-280	336	13	only	only	ADV
admet-280	336	14	minor	minor	ADJ
admet-280	336	15	cyp3a	cyp3a	NOUN
admet-280	336	16	activity	activity	NOUN
admet-280	336	17	,	,	PUNCT
admet-280	336	18	below	below	ADP
admet-280	336	19	that	that	PRON
admet-280	336	20	observed	observe	VERB
admet-280	336	21	in	in	ADP
admet-280	336	22	primary	primary	ADJ
admet-280	336	23	hepatocytes	hepatocyte	NOUN
admet-280	336	24	.	.	PUNCT
admet-280	337	1	these	these	DET
admet-280	337	2	data	datum	NOUN
admet-280	337	3	demonstrates	demonstrate	VERB
admet-280	337	4	that	that	SCONJ
admet-280	337	5	more	more	ADJ
admet-280	337	6	work	work	NOUN
admet-280	337	7	needs	need	VERB
admet-280	337	8	to	to	PART
admet-280	337	9	be	be	AUX
admet-280	337	10	done	do	VERB
admet-280	337	11	to	to	PART
admet-280	337	12	promote	promote	VERB
admet-280	337	13	the	the	DET
admet-280	337	14	maturity	maturity	NOUN
admet-280	337	15	of	of	ADP
admet-280	337	16	scdhs	scdhs	ADJ
admet-280	337	17	.	.	PUNCT
admet-280	338	1	enhanced	enhance	VERB
admet-280	338	2	expression	expression	NOUN
admet-280	338	3	and	and	CCONJ
admet-280	338	4	function	function	NOUN
admet-280	338	5	of	of	ADP
admet-280	338	6	drug	drug	NOUN
admet-280	338	7	-	-	PUNCT
admet-280	338	8	metabolizing	metabolize	VERB
admet-280	338	9	enzymes	enzyme	NOUN
admet-280	338	10	in	in	ADP
admet-280	338	11	scdhs	scdhs	PROPN
admet-280	338	12	would	would	AUX
admet-280	338	13	make	make	VERB
admet-280	338	14	them	they	PRON
admet-280	338	15	a	a	DET
admet-280	338	16	more	more	ADV
admet-280	338	17	viable	viable	ADJ
admet-280	338	18	option	option	NOUN
admet-280	338	19	to	to	PART
admet-280	338	20	supplant	supplant	VERB
admet-280	338	21	primary	primary	ADJ
admet-280	338	22	hepatocytes	hepatocyte	NOUN
admet-280	338	23	in	in	ADP
admet-280	338	24	the	the	DET
admet-280	338	25	pharmaceutical	pharmaceutical	ADJ
admet-280	338	26	industry	industry	NOUN
admet-280	338	27	for	for	ADP
admet-280	338	28	drug	drug	NOUN
admet-280	338	29	metabolism	metabolism	NOUN
admet-280	338	30	/	/	SYM
admet-280	338	31	liver	liver	NOUN
admet-280	338	32	toxicity	toxicity	NOUN
admet-280	338	33	assays	assay	NOUN
admet-280	338	34	.	.	PUNCT
admet-280	339	1	in	in	ADP
admet-280	339	2	addition	addition	NOUN
admet-280	339	3	,	,	PUNCT
admet-280	339	4	scdhs	scdhs	PROPN
admet-280	339	5	may	may	AUX
admet-280	339	6	provide	provide	VERB
admet-280	339	7	an	an	DET
admet-280	339	8	improved	improve	VERB
admet-280	339	9	in	in	ADP
admet-280	339	10	vitro	vitro	X
admet-280	339	11	system	system	NOUN
admet-280	339	12	for	for	ADP
admet-280	339	13	evaluating	evaluate	VERB
admet-280	339	14	genotype	genotype	NOUN
admet-280	339	15	-	-	PUNCT
admet-280	339	16	phenotype	phenotype	NOUN
admet-280	339	17	relationships	relationship	NOUN
admet-280	339	18	of	of	ADP
admet-280	339	19	the	the	DET
admet-280	339	20	cyp	cyp	ADJ
admet-280	339	21	enzymes	enzyme	NOUN
admet-280	339	22	and	and	CCONJ
admet-280	339	23	their	their	PRON
admet-280	339	24	impact	impact	NOUN
admet-280	339	25	on	on	ADP
admet-280	339	26	drug	drug	NOUN
admet-280	339	27	metabolism	metabolism	NOUN
admet-280	339	28	and	and	CCONJ
admet-280	339	29	toxicity	toxicity	NOUN
admet-280	339	30	.	.	PUNCT
admet-280	340	1	this	this	PRON
admet-280	340	2	is	be	AUX
admet-280	340	3	the	the	DET
admet-280	340	4	first	first	ADJ
admet-280	340	5	published	publish	VERB
admet-280	340	6	report	report	NOUN
admet-280	340	7	of	of	ADP
admet-280	340	8	genotyping	genotype	VERB
admet-280	340	9	in	in	ADP
admet-280	340	10	the	the	DET
admet-280	340	11	wicell	wicell	PROPN
admet-280	340	12	®	®	PROPN
admet-280	340	13	hesc	hesc	NOUN
admet-280	340	14	lines	line	NOUN
admet-280	340	15	with	with	ADP
admet-280	340	16	regards	regard	NOUN
admet-280	340	17	to	to	ADP
admet-280	340	18	adme	adme	NOUN
admet-280	340	19	-	-	ADJ
admet-280	340	20	relevant	relevant	ADJ
admet-280	340	21	polymorphisms	polymorphism	NOUN
admet-280	340	22	.	.	PUNCT
admet-280	341	1	in	in	ADP
admet-280	341	2	addition	addition	NOUN
admet-280	341	3	,	,	PUNCT
admet-280	341	4	we	we	PRON
admet-280	341	5	are	be	AUX
admet-280	341	6	able	able	ADJ
admet-280	341	7	to	to	PART
admet-280	341	8	demonstrate	demonstrate	VERB
admet-280	341	9	the	the	DET
admet-280	341	10	cypp2d6	cypp2d6	NUM
admet-280	341	11	*	*	SYM
admet-280	341	12	41	41	NUM
admet-280	341	13	splicing	splicing	NOUN
admet-280	341	14	defect	defect	NOUN
admet-280	341	15	displays	display	NOUN
admet-280	341	16	incomplete	incomplete	ADJ
admet-280	341	17	penetrance	penetrance	NOUN
admet-280	341	18	,	,	PUNCT
admet-280	341	19	with	with	ADP
admet-280	341	20	similar	similar	ADJ
admet-280	341	21	results	result	NOUN
admet-280	341	22	observed	observe	VERB
admet-280	341	23	in	in	ADP
admet-280	341	24	scdhs	scdhs	ADJ
admet-280	341	25	and	and	CCONJ
admet-280	341	26	liver	liver	NOUN
admet-280	341	27	tissue	tissue	NOUN
admet-280	341	28	.	.	PUNCT
admet-280	342	1	the	the	DET
admet-280	342	2	pharmacogenetic	pharmacogenetic	ADJ
admet-280	342	3	data	datum	NOUN
admet-280	342	4	provided	provide	VERB
admet-280	342	5	here	here	ADV
admet-280	342	6	is	be	AUX
admet-280	342	7	vital	vital	ADJ
admet-280	342	8	to	to	ADP
admet-280	342	9	understanding	understand	VERB
admet-280	342	10	metabolism	metabolism	NOUN
admet-280	342	11	profiles	profile	NOUN
admet-280	342	12	when	when	SCONJ
admet-280	342	13	these	these	DET
admet-280	342	14	hesc	hesc	NOUN
admet-280	342	15	lines	line	NOUN
admet-280	342	16	are	be	AUX
admet-280	342	17	used	use	VERB
admet-280	342	18	as	as	ADP
admet-280	342	19	a	a	DET
admet-280	342	20	target	target	NOUN
admet-280	342	21	tissue	tissue	NOUN
admet-280	342	22	source	source	NOUN
admet-280	342	23	for	for	ADP
admet-280	342	24	models	model	NOUN
admet-280	342	25	of	of	ADP
admet-280	342	26	drug	drug	NOUN
admet-280	342	27	metabolism	metabolism	NOUN
admet-280	342	28	and	and	CCONJ
admet-280	342	29	toxicity	toxicity	NOUN
admet-280	342	30	.	.	PUNCT
admet-280	343	1	acknowledgements	acknowledgement	NOUN
admet-280	343	2	the	the	DET
admet-280	343	3	authors	author	NOUN
admet-280	343	4	would	would	AUX
admet-280	343	5	like	like	VERB
admet-280	343	6	to	to	PART
admet-280	343	7	thank	thank	VERB
admet-280	343	8	the	the	DET
admet-280	343	9	university	university	PROPN
admet-280	343	10	of	of	ADP
admet-280	343	11	washington	washington	PROPN
admet-280	343	12	(	(	PUNCT
admet-280	343	13	uw	uw	PROPN
admet-280	343	14	)	)	PUNCT
admet-280	343	15	institute	institute	NOUN
admet-280	343	16	for	for	ADP
admet-280	343	17	stem	stem	NOUN
admet-280	343	18	cell	cell	NOUN
admet-280	343	19	and	and	CCONJ
admet-280	343	20	regenerative	regenerative	ADJ
admet-280	343	21	medicine	medicine	NOUN
admet-280	343	22	,	,	PUNCT
admet-280	343	23	including	include	VERB
admet-280	343	24	carol	carol	NOUN
admet-280	343	25	ware	ware	NOUN
admet-280	343	26	,	,	PUNCT
admet-280	343	27	christopher	christopher	PROPN
admet-280	343	28	cavanaugh	cavanaugh	PROPN
admet-280	343	29	,	,	PUNCT
admet-280	343	30	jennifer	jennifer	PROPN
admet-280	343	31	hesson	hesson	PROPN
admet-280	343	32	and	and	CCONJ
admet-280	343	33	savannah	savannah	PROPN
admet-280	343	34	cook	cook	VERB
admet-280	343	35	for	for	ADP
admet-280	343	36	their	their	PRON
admet-280	343	37	input	input	NOUN
admet-280	343	38	on	on	ADP
admet-280	343	39	culturing	culture	VERB
admet-280	343	40	human	human	ADJ
admet-280	343	41	embryonic	embryonic	ADJ
admet-280	343	42	stem	stem	NOUN
admet-280	343	43	cells	cell	NOUN
admet-280	343	44	.	.	PUNCT
admet-280	344	1	we	we	PRON
admet-280	344	2	would	would	AUX
admet-280	344	3	like	like	VERB
admet-280	344	4	to	to	PART
admet-280	344	5	thank	thank	VERB
admet-280	344	6	david	david	PROPN
admet-280	344	7	hay	hay	PROPN
admet-280	344	8	,	,	PUNCT
admet-280	344	9	sebastian	sebastian	PROPN
admet-280	344	10	greenhough	greenhough	PROPN
admet-280	344	11	and	and	CCONJ
admet-280	344	12	dagmara	dagmara	PROPN
admet-280	344	13	szkolnicka	szkolnicka	NOUN
admet-280	344	14	at	at	ADP
admet-280	344	15	the	the	DET
admet-280	344	16	university	university	PROPN
admet-280	344	17	of	of	ADP
admet-280	344	18	edinburgh	edinburgh	PROPN
admet-280	344	19	for	for	ADP
admet-280	344	20	teaching	teach	VERB
admet-280	344	21	us	we	PRON
admet-280	344	22	their	their	PRON
admet-280	344	23	hepatocyte	hepatocyte	NOUN
admet-280	344	24	differentiation	differentiation	NOUN
admet-280	344	25	protocol	protocol	NOUN
admet-280	344	26	and	and	CCONJ
admet-280	344	27	providing	provide	VERB
admet-280	344	28	some	some	DET
admet-280	344	29	samples	sample	NOUN
admet-280	344	30	.	.	PUNCT
admet-280	345	1	we	we	PRON
admet-280	345	2	would	would	AUX
admet-280	345	3	like	like	VERB
admet-280	345	4	to	to	PART
admet-280	345	5	thank	thank	VERB
admet-280	345	6	sengkeo	sengkeo	PROPN
admet-280	345	7	srinouanprachanh	srinouanprachanh	PROPN
admet-280	345	8	,	,	PUNCT
admet-280	345	9	jesse	jesse	PROPN
admet-280	345	10	tsai	tsai	PROPN
admet-280	345	11	,	,	PUNCT
admet-280	345	12	theo	theo	PROPN
admet-280	345	13	bammler	bammler	NOUN
admet-280	345	14	,	,	PUNCT
admet-280	345	15	fred	fred	PROPN
admet-280	345	16	farin	farin	PROPN
admet-280	345	17	,	,	PUNCT
admet-280	345	18	and	and	CCONJ
admet-280	345	19	richard	richard	PROPN
admet-280	345	20	beyer	beyer	PROPN
admet-280	345	21	for	for	ADP
admet-280	345	22	assistance	assistance	NOUN
admet-280	345	23	in	in	ADP
admet-280	345	24	running	run	VERB
admet-280	345	25	the	the	DET
admet-280	345	26	affymetrix	affymetrix	ADJ
admet-280	345	27	dmet	dmet	NOUN
admet-280	345	28	™	™	NOUN
admet-280	345	29	plus	plus	CCONJ
admet-280	345	30	array	array	NOUN
admet-280	345	31	.	.	PUNCT
admet-280	346	1	we	we	PRON
admet-280	346	2	would	would	AUX
admet-280	346	3	also	also	ADV
admet-280	346	4	like	like	VERB
admet-280	346	5	to	to	PART
admet-280	346	6	thank	thank	VERB
admet-280	346	7	james	james	PROPN
admet-280	346	8	macdonald	macdonald	PROPN
admet-280	346	9	for	for	ADP
admet-280	346	10	assistance	assistance	NOUN
admet-280	346	11	in	in	ADP
admet-280	346	12	submitting	submit	VERB
admet-280	346	13	the	the	DET
admet-280	346	14	array	array	NOUN
admet-280	346	15	data	datum	NOUN
admet-280	346	16	to	to	ADP
admet-280	346	17	the	the	DET
admet-280	346	18	gene	gene	NOUN
admet-280	346	19	expression	expression	NOUN
admet-280	346	20	omnibus	omnibus	NOUN
admet-280	346	21	.	.	PUNCT
admet-280	347	1	support	support	NOUN
admet-280	347	2	was	be	AUX
admet-280	347	3	provided	provide	VERB
admet-280	347	4	for	for	ADP
admet-280	347	5	this	this	DET
admet-280	347	6	work	work	NOUN
admet-280	347	7	in	in	ADP
admet-280	347	8	part	part	NOUN
admet-280	347	9	from	from	ADP
admet-280	347	10	the	the	DET
admet-280	347	11	drug	drug	NOUN
admet-280	347	12	metabolism	metabolism	NOUN
admet-280	347	13	transport	transport	NOUN
admet-280	347	14	and	and	CCONJ
admet-280	347	15	pharmacogenetics	pharmacogenetic	NOUN
admet-280	347	16	research	research	NOUN
admet-280	347	17	fund	fund	NOUN
admet-280	347	18	in	in	ADP
admet-280	347	19	the	the	DET
admet-280	347	20	school	school	NOUN
admet-280	347	21	of	of	ADP
admet-280	347	22	pharmacy	pharmacy	NOUN
admet-280	347	23	,	,	PUNCT
admet-280	347	24	university	university	NOUN
admet-280	347	25	of	of	ADP
admet-280	347	26	washington	washington	PROPN
admet-280	347	27	(	(	PUNCT
admet-280	347	28	to	to	PART
admet-280	347	29	ejk	ejk	VERB
admet-280	347	30	)	)	PUNCT
admet-280	347	31	;	;	PUNCT
admet-280	347	32	es007033	es007033	PROPN
admet-280	347	33	(	(	PUNCT
admet-280	347	34	to	to	PART
admet-280	347	35	ejk	ejk	VERB
admet-280	347	36	)	)	PUNCT
admet-280	347	37	;	;	PUNCT
admet-280	347	38	institute	institute	NOUN
admet-280	347	39	of	of	ADP
admet-280	347	40	translational	translational	PROPN
admet-280	347	41	health	health	PROPN
admet-280	347	42	sciences	sciences	PROPN
admet-280	347	43	ignition	ignition	PROPN
admet-280	347	44	award	award	NOUN
admet-280	347	45	(	(	PUNCT
admet-280	347	46	to	to	PART
admet-280	347	47	ejk	ejk	VERB
admet-280	347	48	)	)	PUNCT
admet-280	347	49	;	;	PUNCT
admet-280	347	50	and	and	CCONJ
admet-280	347	51	t32gm007750	t32gm007750	NOUN
admet-280	347	52	(	(	PUNCT
admet-280	347	53	to	to	ADP
admet-280	347	54	jlv	jlv	PROPN
admet-280	347	55	)	)	PUNCT
admet-280	347	56	.	.	PUNCT
admet-280	348	1	research	research	NOUN
admet-280	348	2	reported	report	VERB
admet-280	348	3	in	in	ADP
admet-280	348	4	this	this	DET
admet-280	348	5	publication	publication	NOUN
admet-280	348	6	was	be	AUX
admet-280	348	7	supported	support	VERB
admet-280	348	8	by	by	ADP
admet-280	348	9	the	the	DET
admet-280	348	10	national	national	ADJ
admet-280	348	11	center	center	NOUN
admet-280	348	12	for	for	ADP
admet-280	348	13	advancing	advance	VERB
admet-280	348	14	translational	translational	ADJ
admet-280	348	15	sciences	science	NOUN
admet-280	348	16	of	of	ADP
admet-280	348	17	the	the	DET
admet-280	348	18	national	national	PROPN
admet-280	348	19	institutes	institutes	PROPN
admet-280	348	20	of	of	ADP
admet-280	348	21	health	health	PROPN
admet-280	348	22	under	under	ADP
admet-280	348	23	award	award	NOUN
admet-280	348	24	number	number	NOUN
admet-280	348	25	tl1tr000422	tl1tr000422	NOUN
admet-280	348	26	(	(	PUNCT
admet-280	348	27	to	to	ADP
admet-280	348	28	jlv	jlv	PROPN
admet-280	348	29	)	)	PUNCT
admet-280	348	30	.	.	PUNCT
admet-280	349	1	the	the	DET
admet-280	349	2	content	content	NOUN
admet-280	349	3	is	be	AUX
admet-280	349	4	solely	solely	ADV
admet-280	349	5	the	the	DET
admet-280	349	6	responsibility	responsibility	NOUN
admet-280	349	7	of	of	ADP
admet-280	349	8	the	the	DET
admet-280	349	9	authors	author	NOUN
admet-280	349	10	and	and	CCONJ
admet-280	349	11	does	do	AUX
admet-280	349	12	not	not	PART
admet-280	349	13	necessarily	necessarily	ADV
admet-280	349	14	represent	represent	VERB
admet-280	349	15	the	the	DET
admet-280	349	16	official	official	ADJ
admet-280	349	17	views	view	NOUN
admet-280	349	18	of	of	ADP
admet-280	349	19	the	the	DET
admet-280	349	20	national	national	PROPN
admet-280	349	21	institutes	institutes	PROPN
admet-280	349	22	of	of	ADP
admet-280	349	23	health	health	NOUN
admet-280	349	24	.	.	PUNCT
admet-280	350	1	references	reference	NOUN
admet-280	350	2	[	[	X
admet-280	350	3	1	1	NUM
admet-280	350	4	]	]	X
admet-280	350	5	f.p	f.p	PROPN
admet-280	350	6	.	.	PROPN
admet-280	350	7	guengerich	guengerich	PROPN
admet-280	350	8	,	,	PUNCT
admet-280	350	9	human	human	ADJ
admet-280	350	10	cytochrome	cytochrome	NOUN
admet-280	350	11	p450	p450	NUM
admet-280	350	12	enzymes	enzyme	NOUN
admet-280	350	13	,	,	PUNCT
admet-280	350	14	in	in	ADP
admet-280	350	15	:	:	PUNCT
admet-280	350	16	p.r.o.d	p.r.o.d	PROPN
admet-280	350	17	.	.	PROPN
admet-280	350	18	montellano	montellano	PROPN
admet-280	350	19	(	(	PUNCT
admet-280	350	20	ed	ed	NOUN
admet-280	350	21	.	.	PUNCT
admet-280	350	22	)	)	PUNCT
admet-280	350	23	cytochrome	cytochrome	NOUN
admet-280	351	1	p450	p450	NOUN
admet-280	351	2	:	:	PUNCT
admet-280	351	3	structure	structure	NOUN
admet-280	351	4	,	,	PUNCT
admet-280	351	5	mechanism	mechanism	NOUN
admet-280	351	6	,	,	PUNCT
admet-280	351	7	and	and	CCONJ
admet-280	351	8	biochemistry	biochemistry	NOUN
admet-280	351	9	,	,	PUNCT
admet-280	351	10	kluwer	kluwer	NOUN
admet-280	351	11	academic	academic	PROPN
admet-280	351	12	/	/	SYM
admet-280	351	13	plenum	plenum	NOUN
admet-280	351	14	publishers	publisher	NOUN
admet-280	351	15	,	,	PUNCT
admet-280	351	16	new	new	PROPN
admet-280	351	17	york	york	PROPN
admet-280	351	18	,	,	PUNCT
admet-280	351	19	2005	2005	NUM
admet-280	351	20	,	,	PUNCT
admet-280	351	21	pp	pp	ADJ
admet-280	351	22	.	.	PUNCT
admet-280	352	1	377	377	NUM
admet-280	352	2	-	-	SYM
admet-280	352	3	530	530	NUM
admet-280	352	4	.	.	PUNCT
admet-280	353	1	[	[	X
admet-280	353	2	2	2	X
admet-280	353	3	]	]	PUNCT
admet-280	353	4	h.	h.	PROPN
admet-280	353	5	zhang	zhang	PROPN
admet-280	353	6	,	,	PUNCT
admet-280	353	7	c.d	c.d	PROPN
admet-280	353	8	.	.	PROPN
admet-280	353	9	davis	davis	PROPN
admet-280	353	10	,	,	PUNCT
admet-280	353	11	m.w	m.w	PROPN
admet-280	353	12	.	.	PROPN
admet-280	353	13	sinz	sinz	PROPN
admet-280	353	14	,	,	PUNCT
admet-280	353	15	a.d	a.d	PROPN
admet-280	353	16	.	.	PROPN
admet-280	353	17	rodrigues	rodrigues	PROPN
admet-280	353	18	,	,	PUNCT
admet-280	353	19	expert	expert	NOUN
admet-280	353	20	opin	opin	NOUN
admet-280	353	21	drug	drug	NOUN
admet-280	353	22	metab	metab	NOUN
admet-280	353	23	toxicol	toxicol	NOUN
admet-280	353	24	3	3	NUM
admet-280	353	25	(	(	PUNCT
admet-280	353	26	2007	2007	NUM
admet-280	353	27	)	)	PUNCT
admet-280	353	28	667	667	NUM
admet-280	353	29	-	-	NUM
admet-280	353	30	687	687	NUM
admet-280	353	31	.	.	PUNCT
admet-280	354	1	admet	admet	PROPN
admet-280	354	2	&	&	CCONJ
admet-280	354	3	dmpk	dmpk	PROPN
admet-280	354	4	4(2	4(2	NUM
admet-280	354	5	)	)	PUNCT
admet-280	354	6	(	(	PUNCT
admet-280	354	7	2016	2016	NUM
admet-280	354	8	)	)	PUNCT
admet-280	354	9	62	62	NUM
admet-280	354	10	-	-	SYM
admet-280	354	11	83	83	NUM
admet-280	354	12	pharmacogenetics	pharmacogenetic	NOUN
admet-280	354	13	and	and	CCONJ
admet-280	354	14	cyp	cyp	ADJ
admet-280	354	15	activity	activity	NOUN
admet-280	354	16	doi	doi	NOUN
admet-280	354	17	:	:	PUNCT
admet-280	354	18	10.5599	10.5599	NUM
admet-280	354	19	/	/	SYM
admet-280	354	20	admet.4.2.280	admet.4.2.280	VERB
admet-280	354	21	79	79	NUM
admet-280	355	1	[	[	X
admet-280	355	2	3	3	NUM
admet-280	355	3	]	]	X
admet-280	355	4	j.m	j.m	PROPN
admet-280	355	5	.	.	PROPN
admet-280	355	6	mckim	mckim	PROPN
admet-280	355	7	,	,	PUNCT
admet-280	355	8	in	in	ADP
admet-280	355	9	vitro	vitro	X
admet-280	355	10	approaches	approach	NOUN
admet-280	355	11	for	for	ADP
admet-280	355	12	determining	determine	VERB
admet-280	355	13	liver	liver	NOUN
admet-280	355	14	-	-	PUNCT
admet-280	355	15	specific	specific	ADJ
admet-280	355	16	toxicity	toxicity	NOUN
admet-280	355	17	of	of	ADP
admet-280	355	18	new	new	ADJ
admet-280	355	19	drug	drug	NOUN
admet-280	355	20	candidates	candidate	NOUN
admet-280	355	21	,	,	PUNCT
admet-280	355	22	in	in	ADP
admet-280	355	23	:	:	PUNCT
admet-280	355	24	a.g	a.g	PROPN
admet-280	355	25	.	.	PROPN
admet-280	355	26	wilson	wilson	PROPN
admet-280	355	27	(	(	PUNCT
admet-280	355	28	ed	ed	NOUN
admet-280	355	29	.	.	PUNCT
admet-280	355	30	)	)	PUNCT
admet-280	356	1	new	new	ADJ
admet-280	356	2	horizons	horizon	NOUN
admet-280	356	3	in	in	ADP
admet-280	356	4	predictive	predictive	ADJ
admet-280	356	5	toxicology	toxicology	NOUN
admet-280	356	6	:	:	PUNCT
admet-280	356	7	current	current	ADJ
admet-280	356	8	status	status	NOUN
admet-280	356	9	and	and	CCONJ
admet-280	356	10	application	application	NOUN
admet-280	356	11	,	,	PUNCT
admet-280	356	12	the	the	DET
admet-280	356	13	royal	royal	ADJ
admet-280	356	14	society	society	NOUN
admet-280	356	15	of	of	ADP
admet-280	356	16	chemistry	chemistry	NOUN
admet-280	356	17	,	,	PUNCT
admet-280	356	18	cambridge	cambridge	PROPN
admet-280	356	19	,	,	PUNCT
admet-280	356	20	2012	2012	NUM
admet-280	356	21	,	,	PUNCT
admet-280	356	22	pp	pp	ADJ
admet-280	356	23	.	.	PUNCT
admet-280	357	1	157	157	NUM
admet-280	357	2	-	-	SYM
admet-280	357	3	214	214	NUM
admet-280	357	4	.	.	PUNCT
admet-280	358	1	[	[	X
admet-280	358	2	4	4	NUM
admet-280	358	3	]	]	X
admet-280	358	4	i.	i.	PROPN
admet-280	358	5	johansson	johansson	PROPN
admet-280	358	6	,	,	PUNCT
admet-280	358	7	m.	m.	NOUN
admet-280	358	8	ingelman	ingelman	NOUN
admet-280	358	9	-	-	PUNCT
admet-280	358	10	sundberg	sundberg	ADJ
admet-280	358	11	,	,	PUNCT
admet-280	358	12	toxicological	toxicological	ADJ
admet-280	358	13	sciences	science	NOUN
admet-280	358	14	120	120	NUM
admet-280	358	15	(	(	PUNCT
admet-280	358	16	2010	2010	NUM
admet-280	358	17	)	)	PUNCT
admet-280	358	18	1	1	NUM
admet-280	358	19	-	-	SYM
admet-280	358	20	13	13	NUM
admet-280	358	21	.	.	PUNCT
admet-280	359	1	[	[	X
admet-280	359	2	5	5	NUM
admet-280	359	3	]	]	X
admet-280	359	4	j.c	j.c	PROPN
admet-280	359	5	.	.	PROPN
admet-280	359	6	davila	davila	PROPN
admet-280	359	7	,	,	PUNCT
admet-280	359	8	toxicological	toxicological	ADJ
admet-280	359	9	sciences	science	NOUN
admet-280	359	10	79	79	NUM
admet-280	359	11	(	(	PUNCT
admet-280	359	12	2004	2004	NUM
admet-280	359	13	)	)	PUNCT
admet-280	359	14	214	214	NUM
admet-280	359	15	-	-	SYM
admet-280	359	16	223	223	NUM
admet-280	359	17	.	.	PUNCT
admet-280	360	1	[	[	X
admet-280	360	2	6	6	NUM
admet-280	360	3	]	]	PUNCT
admet-280	360	4	claire	claire	PROPN
admet-280	360	5	n.	n.	PROPN
admet-280	360	6	medine	medine	PROPN
admet-280	360	7	,	,	PUNCT
admet-280	360	8	s.	s.	PROPN
admet-280	360	9	greenhough	greenhough	PROPN
admet-280	360	10	,	,	PUNCT
admet-280	360	11	david	david	PROPN
admet-280	360	12	c.	c.	PROPN
admet-280	360	13	hay	hay	PROPN
admet-280	360	14	,	,	PUNCT
admet-280	360	15	biochemical	biochemical	ADJ
admet-280	360	16	society	society	NOUN
admet-280	360	17	transactions	transaction	NOUN
admet-280	360	18	38	38	NUM
admet-280	360	19	(	(	PUNCT
admet-280	360	20	2010	2010	NUM
admet-280	360	21	)	)	PUNCT
admet-280	360	22	1033	1033	NUM
admet-280	360	23	.	.	PUNCT
admet-280	361	1	[	[	X
admet-280	361	2	7	7	X
admet-280	361	3	]	]	X
admet-280	361	4	p.	p.	NOUN
admet-280	361	5	godoy	godoy	PROPN
admet-280	361	6	,	,	PUNCT
admet-280	361	7	n.j	n.j	PROPN
admet-280	361	8	.	.	PROPN
admet-280	361	9	hewitt	hewitt	PROPN
admet-280	361	10	,	,	PUNCT
admet-280	361	11	u.	u.	PROPN
admet-280	361	12	albrecht	albrecht	PROPN
admet-280	361	13	,	,	PUNCT
admet-280	361	14	m.e	m.e	PROPN
admet-280	361	15	.	.	PROPN
admet-280	361	16	andersen	andersen	PROPN
admet-280	361	17	,	,	PUNCT
admet-280	361	18	n.	n.	PROPN
admet-280	361	19	ansari	ansari	PROPN
admet-280	361	20	,	,	PUNCT
admet-280	361	21	s.	s.	PROPN
admet-280	361	22	bhattacharya	bhattacharya	PROPN
admet-280	361	23	,	,	PUNCT
admet-280	361	24	j.g	j.g	PROPN
admet-280	361	25	.	.	PROPN
admet-280	361	26	bode	bode	PROPN
admet-280	361	27	,	,	PUNCT
admet-280	361	28	j.	j.	PROPN
admet-280	361	29	bolleyn	bolleyn	PROPN
admet-280	361	30	,	,	PUNCT
admet-280	361	31	c.	c.	PROPN
admet-280	361	32	borner	borner	PROPN
admet-280	361	33	,	,	PUNCT
admet-280	361	34	j.	j.	PROPN
admet-280	361	35	böttger	böttger	PROPN
admet-280	361	36	,	,	PUNCT
admet-280	361	37	a.	a.	NOUN
admet-280	361	38	braeuning	braeuning	NOUN
admet-280	361	39	,	,	PUNCT
admet-280	361	40	r.a	r.a	PROPN
admet-280	361	41	.	.	PROPN
admet-280	361	42	budinsky	budinsky	PROPN
admet-280	361	43	,	,	PUNCT
admet-280	361	44	b.	b.	PROPN
admet-280	361	45	burkhardt	burkhardt	PROPN
admet-280	361	46	,	,	PUNCT
admet-280	361	47	n.r	n.r	PROPN
admet-280	361	48	.	.	PROPN
admet-280	361	49	cameron	cameron	PROPN
admet-280	361	50	,	,	PUNCT
admet-280	361	51	g.	g.	PROPN
admet-280	361	52	camussi	camussi	PROPN
admet-280	361	53	,	,	PUNCT
admet-280	361	54	c.-s	c.-	NOUN
admet-280	361	55	.	.	PUNCT
admet-280	362	1	cho	cho	PROPN
admet-280	362	2	,	,	PUNCT
admet-280	362	3	y.-j	y.-j	PROPN
admet-280	362	4	.	.	PUNCT
admet-280	363	1	choi	choi	PROPN
admet-280	363	2	,	,	PUNCT
admet-280	363	3	j.	j.	PROPN
admet-280	363	4	craig	craig	PROPN
admet-280	363	5	rowlands	rowlands	PROPN
admet-280	363	6	,	,	PUNCT
admet-280	363	7	u.	u.	PROPN
admet-280	363	8	dahmen	dahmen	PROPN
admet-280	363	9	,	,	PUNCT
admet-280	363	10	g.	g.	PROPN
admet-280	363	11	damm	damm	PROPN
admet-280	363	12	,	,	PUNCT
admet-280	363	13	o.	o.	PROPN
admet-280	363	14	dirsch	dirsch	PROPN
admet-280	363	15	,	,	PUNCT
admet-280	363	16	m.t	m.t	PROPN
admet-280	363	17	.	.	PROPN
admet-280	363	18	donato	donato	PROPN
admet-280	363	19	,	,	PUNCT
admet-280	363	20	j.	j.	PROPN
admet-280	363	21	dong	dong	PROPN
admet-280	363	22	,	,	PUNCT
admet-280	363	23	s.	s.	PROPN
admet-280	363	24	dooley	dooley	PROPN
admet-280	363	25	,	,	PUNCT
admet-280	363	26	d.	d.	PROPN
admet-280	363	27	drasdo	drasdo	PROPN
admet-280	363	28	,	,	PUNCT
admet-280	363	29	r.	r.	PROPN
admet-280	363	30	eakins	eakins	PROPN
admet-280	363	31	,	,	PUNCT
admet-280	363	32	k.s	k.s	PROPN
admet-280	363	33	.	.	PROPN
admet-280	363	34	ferreira	ferreira	PROPN
admet-280	363	35	,	,	PUNCT
admet-280	363	36	v.	v.	ADP
admet-280	363	37	fonsato	fonsato	PROPN
admet-280	363	38	,	,	PUNCT
admet-280	363	39	j.	j.	PROPN
admet-280	363	40	fraczek	fraczek	PROPN
admet-280	363	41	,	,	PUNCT
admet-280	363	42	r.	r.	PROPN
admet-280	363	43	gebhardt	gebhardt	PROPN
admet-280	363	44	,	,	PUNCT
admet-280	363	45	a.	a.	PROPN
admet-280	363	46	gibson	gibson	PROPN
admet-280	363	47	,	,	PUNCT
admet-280	363	48	m.	m.	PROPN
admet-280	363	49	glanemann	glanemann	PROPN
admet-280	363	50	,	,	PUNCT
admet-280	363	51	c.e.p	c.e.p	PROPN
admet-280	363	52	.	.	PROPN
admet-280	363	53	goldring	goldring	PROPN
admet-280	363	54	,	,	PUNCT
admet-280	363	55	m.j	m.j	PROPN
admet-280	363	56	.	.	PROPN
admet-280	363	57	gómez	gómez	PROPN
admet-280	363	58	-	-	PUNCT
admet-280	363	59	lechón	lechón	PROPN
admet-280	363	60	,	,	PUNCT
admet-280	363	61	g.m.m	g.m.m	NOUN
admet-280	363	62	.	.	PUNCT
admet-280	363	63	groothuis	groothuis	PROPN
admet-280	363	64	,	,	PUNCT
admet-280	363	65	l.	l.	PROPN
admet-280	363	66	gustavsson	gustavsson	PROPN
admet-280	363	67	,	,	PUNCT
admet-280	363	68	c.	c.	PROPN
admet-280	363	69	guyot	guyot	PROPN
admet-280	363	70	,	,	PUNCT
admet-280	363	71	d.	d.	PROPN
admet-280	363	72	hallifax	hallifax	PROPN
admet-280	363	73	,	,	PUNCT
admet-280	363	74	s.	s.	PROPN
admet-280	363	75	hammad	hammad	PROPN
admet-280	363	76	,	,	PUNCT
admet-280	363	77	a.	a.	PROPN
admet-280	363	78	hayward	hayward	PROPN
admet-280	363	79	,	,	PUNCT
admet-280	363	80	d.	d.	PROPN
admet-280	363	81	häussinger	häussinger	PROPN
admet-280	363	82	,	,	PUNCT
admet-280	363	83	c.	c.	PROPN
admet-280	363	84	hellerbrand	hellerbrand	PROPN
admet-280	363	85	,	,	PUNCT
admet-280	363	86	p.	p.	PROPN
admet-280	363	87	hewitt	hewitt	PROPN
admet-280	363	88	,	,	PUNCT
admet-280	363	89	s.	s.	PROPN
admet-280	363	90	hoehme	hoehme	PROPN
admet-280	363	91	,	,	PUNCT
admet-280	363	92	h.-g	h.-g	PROPN
admet-280	363	93	.	.	PUNCT
admet-280	364	1	holzhütter	holzhütter	PROPN
admet-280	364	2	,	,	PUNCT
admet-280	364	3	j.b	j.b	PROPN
admet-280	364	4	.	.	PROPN
admet-280	364	5	houston	houston	PROPN
admet-280	364	6	,	,	PUNCT
admet-280	364	7	j.	j.	PROPN
admet-280	364	8	hrach	hrach	PROPN
admet-280	364	9	,	,	PUNCT
admet-280	364	10	k.	k.	PROPN
admet-280	364	11	ito	ito	PROPN
admet-280	364	12	,	,	PUNCT
admet-280	364	13	h.	h.	PROPN
admet-280	364	14	jaeschke	jaeschke	PROPN
admet-280	364	15	,	,	PUNCT
admet-280	364	16	v.	v.	PROPN
admet-280	364	17	keitel	keitel	PROPN
admet-280	364	18	,	,	PUNCT
admet-280	364	19	j.m	j.m	PROPN
admet-280	364	20	.	.	PROPN
admet-280	364	21	kelm	kelm	PROPN
admet-280	364	22	,	,	PUNCT
admet-280	364	23	b.	b.	PROPN
admet-280	364	24	kevin	kevin	PROPN
admet-280	364	25	park	park	PROPN
admet-280	364	26	,	,	PUNCT
admet-280	364	27	c.	c.	PROPN
admet-280	364	28	kordes	kordes	PROPN
admet-280	364	29	,	,	PUNCT
admet-280	364	30	g.a	g.a	PROPN
admet-280	364	31	.	.	PROPN
admet-280	364	32	kullak	kullak	PROPN
admet-280	364	33	-	-	PROPN
admet-280	364	34	ublick	ublick	PROPN
admet-280	364	35	,	,	PUNCT
admet-280	364	36	e.l	e.l	PROPN
admet-280	364	37	.	.	PROPN
admet-280	364	38	lecluyse	lecluyse	PROPN
admet-280	364	39	,	,	PUNCT
admet-280	364	40	p.	p.	PROPN
admet-280	364	41	lu	lu	PROPN
admet-280	364	42	,	,	PUNCT
admet-280	364	43	j.	j.	PROPN
admet-280	364	44	luebke	luebke	PROPN
admet-280	364	45	-	-	PUNCT
admet-280	364	46	wheeler	wheeler	NOUN
admet-280	364	47	,	,	PUNCT
admet-280	364	48	a.	a.	PROPN
admet-280	364	49	lutz	lutz	PROPN
admet-280	364	50	,	,	PUNCT
admet-280	364	51	d.j	d.j	PROPN
admet-280	364	52	.	.	PROPN
admet-280	364	53	maltman	maltman	PROPN
admet-280	364	54	,	,	PUNCT
admet-280	364	55	m.	m.	PROPN
admet-280	364	56	matz	matz	PROPN
admet-280	364	57	-	-	PUNCT
admet-280	364	58	soja	soja	PROPN
admet-280	364	59	,	,	PUNCT
admet-280	364	60	p.	p.	PROPN
admet-280	364	61	mcmullen	mcmullen	PROPN
admet-280	364	62	,	,	PUNCT
admet-280	364	63	i.	i.	PROPN
admet-280	364	64	merfort	merfort	PROPN
admet-280	364	65	,	,	PUNCT
admet-280	364	66	s.	s.	PROPN
admet-280	364	67	messner	messner	PROPN
admet-280	364	68	,	,	PUNCT
admet-280	364	69	c.	c.	PROPN
admet-280	364	70	meyer	meyer	PROPN
admet-280	364	71	,	,	PUNCT
admet-280	364	72	j.	j.	PROPN
admet-280	364	73	mwinyi	mwinyi	PROPN
admet-280	364	74	,	,	PUNCT
admet-280	364	75	d.j	d.j	PROPN
admet-280	364	76	.	.	PROPN
admet-280	364	77	naisbitt	naisbitt	PROPN
admet-280	364	78	,	,	PUNCT
admet-280	364	79	a.k	a.k	PROPN
admet-280	364	80	.	.	PROPN
admet-280	364	81	nussler	nussler	PROPN
admet-280	364	82	,	,	PUNCT
admet-280	364	83	p.	p.	NOUN
admet-280	364	84	olinga	olinga	PROPN
admet-280	364	85	,	,	PUNCT
admet-280	364	86	f.	f.	PROPN
admet-280	364	87	pampaloni	pampaloni	PROPN
admet-280	364	88	,	,	PUNCT
admet-280	364	89	j.	j.	PROPN
admet-280	364	90	pi	pi	PROPN
admet-280	364	91	,	,	PUNCT
admet-280	364	92	l.	l.	PROPN
admet-280	364	93	pluta	pluta	PROPN
admet-280	364	94	,	,	PUNCT
admet-280	364	95	s.a	s.a	PROPN
admet-280	364	96	.	.	PROPN
admet-280	364	97	przyborski	przyborski	PROPN
admet-280	364	98	,	,	PUNCT
admet-280	364	99	a.	a.	NOUN
admet-280	364	100	ramachandran	ramachandran	PROPN
admet-280	364	101	,	,	PUNCT
admet-280	364	102	v.	v.	CCONJ
admet-280	364	103	rogiers	rogier	NOUN
admet-280	364	104	,	,	PUNCT
admet-280	364	105	c.	c.	PROPN
admet-280	364	106	rowe	rowe	PROPN
admet-280	364	107	,	,	PUNCT
admet-280	364	108	c.	c.	PROPN
admet-280	364	109	schelcher	schelcher	PROPN
admet-280	364	110	,	,	PUNCT
admet-280	364	111	k.	k.	PROPN
admet-280	364	112	schmich	schmich	PROPN
admet-280	364	113	,	,	PUNCT
admet-280	364	114	m.	m.	NOUN
admet-280	364	115	schwarz	schwarz	PROPN
admet-280	364	116	,	,	PUNCT
admet-280	364	117	b.	b.	PROPN
admet-280	364	118	singh	singh	PROPN
admet-280	364	119	,	,	PUNCT
admet-280	364	120	e.h.k	e.h.k	NOUN
admet-280	364	121	.	.	PUNCT
admet-280	364	122	stelzer	stelzer	PROPN
admet-280	364	123	,	,	PUNCT
admet-280	364	124	b.	b.	PROPN
admet-280	364	125	stieger	stieger	PROPN
admet-280	364	126	,	,	PUNCT
admet-280	364	127	r.	r.	PROPN
admet-280	364	128	stöber	stöber	PROPN
admet-280	364	129	,	,	PUNCT
admet-280	364	130	y.	y.	PROPN
admet-280	364	131	sugiyama	sugiyama	PROPN
admet-280	364	132	,	,	PUNCT
admet-280	364	133	c.	c.	PROPN
admet-280	364	134	tetta	tetta	PROPN
admet-280	364	135	,	,	PUNCT
admet-280	364	136	w.e	w.e	PROPN
admet-280	364	137	.	.	PROPN
admet-280	364	138	thasler	thasler	PROPN
admet-280	364	139	,	,	PUNCT
admet-280	364	140	t.	t.	NOUN
admet-280	364	141	vanhaecke	vanhaecke	NOUN
admet-280	364	142	,	,	PUNCT
admet-280	364	143	m.	m.	NOUN
admet-280	364	144	vinken	vinken	VERB
admet-280	364	145	,	,	PUNCT
admet-280	364	146	t.s	t.s	PROPN
admet-280	364	147	.	.	PROPN
admet-280	364	148	weiss	weiss	PROPN
admet-280	364	149	,	,	PUNCT
admet-280	364	150	a.	a.	NOUN
admet-280	364	151	widera	widera	NOUN
admet-280	364	152	,	,	PUNCT
admet-280	364	153	c.g	c.g	PROPN
admet-280	364	154	.	.	PROPN
admet-280	364	155	woods	woods	PROPN
admet-280	364	156	,	,	PUNCT
admet-280	364	157	j.j	j.j	PROPN
admet-280	364	158	.	.	PROPN
admet-280	364	159	xu	xu	PROPN
admet-280	364	160	,	,	PUNCT
admet-280	364	161	k.m	k.m	PROPN
admet-280	364	162	.	.	PROPN
admet-280	364	163	yarborough	yarborough	PROPN
admet-280	364	164	,	,	PUNCT
admet-280	364	165	j.g	j.g	PROPN
admet-280	364	166	.	.	PROPN
admet-280	364	167	hengstler	hengstler	PROPN
admet-280	364	168	,	,	PUNCT
admet-280	364	169	archives	archive	NOUN
admet-280	364	170	of	of	ADP
admet-280	364	171	toxicology	toxicology	NOUN
admet-280	364	172	87	87	NUM
admet-280	364	173	(	(	PUNCT
admet-280	364	174	2013	2013	NUM
admet-280	364	175	)	)	PUNCT
admet-280	364	176	1315	1315	NUM
admet-280	364	177	-	-	SYM
admet-280	364	178	1530	1530	NUM
admet-280	364	179	.	.	PUNCT
admet-280	365	1	[	[	X
admet-280	365	2	8	8	NUM
admet-280	365	3	]	]	X
admet-280	365	4	d.	d.	PROPN
admet-280	365	5	szkolnicka	szkolnicka	PROPN
admet-280	365	6	,	,	PUNCT
admet-280	365	7	w.	w.	PROPN
admet-280	365	8	zhou	zhou	PROPN
admet-280	365	9	,	,	PUNCT
admet-280	365	10	b.	b.	PROPN
admet-280	365	11	lucendo	lucendo	PROPN
admet-280	365	12	-	-	PUNCT
admet-280	365	13	villarin	villarin	PROPN
admet-280	365	14	,	,	PUNCT
admet-280	365	15	d.c	d.c	PROPN
admet-280	365	16	.	.	PUNCT
admet-280	365	17	hay	hay	PROPN
admet-280	365	18	,	,	PUNCT
admet-280	365	19	annual	annual	ADJ
admet-280	365	20	review	review	NOUN
admet-280	365	21	of	of	ADP
admet-280	365	22	pharmacology	pharmacology	NOUN
admet-280	365	23	and	and	CCONJ
admet-280	365	24	toxicology	toxicology	NOUN
admet-280	365	25	53	53	NUM
admet-280	365	26	(	(	PUNCT
admet-280	365	27	2013	2013	NUM
admet-280	365	28	)	)	PUNCT
admet-280	365	29	147	147	NUM
admet-280	365	30	-	-	SYM
admet-280	365	31	159	159	NUM
admet-280	365	32	.	.	PUNCT
admet-280	366	1	[	[	X
admet-280	366	2	9	9	NUM
admet-280	366	3	]	]	X
admet-280	366	4	w.e	w.e	PROPN
admet-280	366	5	.	.	PROPN
admet-280	366	6	evans	evans	PROPN
admet-280	366	7	,	,	PUNCT
admet-280	366	8	science	science	NOUN
admet-280	366	9	286	286	NUM
admet-280	366	10	(	(	PUNCT
admet-280	366	11	1999	1999	NUM
admet-280	366	12	)	)	PUNCT
admet-280	366	13	487	487	NUM
admet-280	366	14	-	-	SYM
admet-280	366	15	491	491	NUM
admet-280	366	16	.	.	PUNCT
admet-280	367	1	[	[	X
admet-280	367	2	10	10	NUM
admet-280	367	3	]	]	X
admet-280	367	4	l.c	l.c	PROPN
admet-280	367	5	.	.	PROPN
admet-280	367	6	wienkers	wienker	NOUN
admet-280	367	7	,	,	PUNCT
admet-280	367	8	t.g	t.g	PROPN
admet-280	367	9	.	.	PROPN
admet-280	367	10	heath	heath	PROPN
admet-280	367	11	,	,	PUNCT
admet-280	367	12	nature	nature	NOUN
admet-280	367	13	reviews	review	VERB
admet-280	367	14	drug	drug	NOUN
admet-280	367	15	discovery	discovery	NOUN
admet-280	367	16	4	4	NUM
admet-280	367	17	(	(	PUNCT
admet-280	367	18	2005	2005	NUM
admet-280	367	19	)	)	PUNCT
admet-280	367	20	825	825	NUM
admet-280	367	21	-	-	SYM
admet-280	367	22	833	833	NUM
admet-280	367	23	.	.	PUNCT
admet-280	368	1	[	[	X
admet-280	368	2	11	11	NUM
admet-280	368	3	]	]	X
admet-280	368	4	d.c	d.c	PROPN
admet-280	368	5	.	.	PUNCT
admet-280	368	6	hay	hay	PROPN
admet-280	368	7	,	,	PUNCT
admet-280	368	8	j.	j.	PROPN
admet-280	368	9	fletcher	fletcher	PROPN
admet-280	368	10	,	,	PUNCT
admet-280	368	11	c.	c.	PROPN
admet-280	368	12	payne	payne	PROPN
admet-280	368	13	,	,	PUNCT
admet-280	368	14	j.d	j.d	PROPN
admet-280	368	15	.	.	PROPN
admet-280	368	16	terrace	terrace	NOUN
admet-280	368	17	,	,	PUNCT
admet-280	369	1	r.c.j	r.c.j	NOUN
admet-280	369	2	.	.	PUNCT
admet-280	369	3	gallagher	gallagher	PROPN
admet-280	369	4	,	,	PUNCT
admet-280	369	5	j.	j.	PROPN
admet-280	369	6	snoeys	snoeys	PROPN
admet-280	369	7	,	,	PUNCT
admet-280	369	8	j.r	j.r	PROPN
admet-280	369	9	.	.	PROPN
admet-280	369	10	black	black	PROPN
admet-280	369	11	,	,	PUNCT
admet-280	369	12	d.	d.	PROPN
admet-280	369	13	wojtacha	wojtacha	PROPN
admet-280	369	14	,	,	PUNCT
admet-280	369	15	k.	k.	PROPN
admet-280	369	16	samuel	samuel	PROPN
admet-280	369	17	,	,	PUNCT
admet-280	369	18	z.	z.	PROPN
admet-280	369	19	hannoun	hannoun	PROPN
admet-280	369	20	,	,	PUNCT
admet-280	369	21	a.	a.	NOUN
admet-280	369	22	pryde	pryde	PROPN
admet-280	369	23	,	,	PUNCT
admet-280	369	24	c.	c.	PROPN
admet-280	369	25	filippi	filippi	PROPN
admet-280	369	26	,	,	PUNCT
admet-280	369	27	i.s	i.s	PROPN
admet-280	369	28	.	.	PROPN
admet-280	369	29	currie	currie	PROPN
admet-280	369	30	,	,	PUNCT
admet-280	369	31	s.j	s.j	PROPN
admet-280	369	32	.	.	PROPN
admet-280	369	33	forbes	forbes	PROPN
admet-280	369	34	,	,	PUNCT
admet-280	369	35	j.a	j.a	PROPN
admet-280	369	36	.	.	PROPN
admet-280	369	37	ross	ross	PROPN
admet-280	369	38	,	,	PUNCT
admet-280	369	39	p.n	p.n	PROPN
admet-280	369	40	.	.	PROPN
admet-280	369	41	newsome	newsome	PROPN
admet-280	369	42	,	,	PUNCT
admet-280	369	43	j.p	j.p	PROPN
admet-280	369	44	.	.	PROPN
admet-280	369	45	iredale	iredale	PROPN
admet-280	369	46	,	,	PUNCT
admet-280	369	47	proceedings	proceeding	NOUN
admet-280	369	48	of	of	ADP
admet-280	369	49	the	the	DET
admet-280	369	50	national	national	PROPN
admet-280	369	51	academy	academy	PROPN
admet-280	369	52	of	of	ADP
admet-280	369	53	sciences	sciences	PROPN
admet-280	369	54	105	105	NUM
admet-280	369	55	(	(	PUNCT
admet-280	369	56	2008	2008	NUM
admet-280	369	57	)	)	PUNCT
admet-280	369	58	12301	12301	NUM
admet-280	369	59	-	-	SYM
admet-280	369	60	12306	12306	NUM
admet-280	369	61	.	.	PUNCT
admet-280	370	1	[	[	X
admet-280	370	2	12	12	NUM
admet-280	370	3	]	]	X
admet-280	370	4	d.	d.	PROPN
admet-280	370	5	szkolnicka	szkolnicka	PROPN
admet-280	370	6	,	,	PUNCT
admet-280	370	7	s.l	s.l	PROPN
admet-280	370	8	.	.	PROPN
admet-280	370	9	farnworth	farnworth	PROPN
admet-280	370	10	,	,	PUNCT
admet-280	370	11	b.	b.	PROPN
admet-280	370	12	lucendo	lucendo	PROPN
admet-280	370	13	-	-	PUNCT
admet-280	370	14	villarin	villarin	PROPN
admet-280	370	15	,	,	PUNCT
admet-280	370	16	d.c	d.c	PROPN
admet-280	370	17	.	.	PUNCT
admet-280	370	18	hay	hay	PROPN
admet-280	370	19	,	,	PUNCT
admet-280	370	20	curr	curr	PROPN
admet-280	370	21	protoc	protoc	VERB
admet-280	370	22	stem	stem	NOUN
admet-280	370	23	cell	cell	NOUN
admet-280	370	24	biol	biol	NOUN
admet-280	370	25	30	30	NUM
admet-280	370	26	(	(	PUNCT
admet-280	370	27	2014	2014	NUM
admet-280	370	28	)	)	PUNCT
admet-280	371	1	1	1	NUM
admet-280	371	2	g	g	NOUN
admet-280	371	3	5	5	NUM
admet-280	371	4	11	11	NUM
admet-280	371	5	g	g	NOUN
admet-280	371	6	5	5	NUM
admet-280	371	7	12	12	NUM
admet-280	371	8	.	.	PUNCT
admet-280	372	1	[	[	X
admet-280	372	2	13	13	NUM
admet-280	372	3	]	]	X
admet-280	372	4	m.f	m.f	PROPN
admet-280	372	5	.	.	PROPN
admet-280	372	6	paine	paine	PROPN
admet-280	372	7	,	,	PUNCT
admet-280	372	8	m.	m.	PROPN
admet-280	372	9	khalighi	khalighi	PROPN
admet-280	372	10	,	,	PUNCT
admet-280	372	11	j.m	j.m	PROPN
admet-280	372	12	.	.	PROPN
admet-280	372	13	fisher	fisher	PROPN
admet-280	372	14	,	,	PUNCT
admet-280	372	15	d.d	d.d	PROPN
admet-280	372	16	.	.	PROPN
admet-280	372	17	shen	shen	PROPN
admet-280	372	18	,	,	PUNCT
admet-280	372	19	k.l	k.l	PROPN
admet-280	372	20	.	.	PROPN
admet-280	372	21	kunze	kunze	PROPN
admet-280	372	22	,	,	PUNCT
admet-280	372	23	c.l	c.l	PROPN
admet-280	372	24	.	.	PROPN
admet-280	372	25	marsh	marsh	PROPN
admet-280	372	26	,	,	PUNCT
admet-280	372	27	j.d	j.d	PROPN
admet-280	372	28	.	.	PROPN
admet-280	372	29	perkins	perkins	PROPN
admet-280	372	30	,	,	PUNCT
admet-280	372	31	k.e	k.e	PROPN
admet-280	372	32	.	.	PROPN
admet-280	372	33	thummel	thummel	PROPN
admet-280	372	34	,	,	PUNCT
admet-280	372	35	the	the	DET
admet-280	372	36	journal	journal	NOUN
admet-280	372	37	of	of	ADP
admet-280	372	38	pharmacology	pharmacology	NOUN
admet-280	372	39	and	and	CCONJ
admet-280	372	40	experimental	experimental	ADJ
admet-280	372	41	therapeutics	therapeutic	NOUN
admet-280	372	42	283	283	NUM
admet-280	372	43	(	(	PUNCT
admet-280	372	44	1997	1997	NUM
admet-280	372	45	)	)	PUNCT
admet-280	372	46	1552	1552	NUM
admet-280	372	47	-	-	SYM
admet-280	372	48	1562	1562	NUM
admet-280	372	49	.	.	PUNCT
admet-280	373	1	[	[	X
admet-280	373	2	14	14	NUM
admet-280	373	3	]	]	X
admet-280	373	4	l.	l.	PROPN
admet-280	373	5	liu	liu	PROPN
admet-280	373	6	,	,	PUNCT
admet-280	373	7	g.m	g.m	PROPN
admet-280	373	8	.	.	PROPN
admet-280	373	9	mugundu	mugundu	NOUN
admet-280	373	10	,	,	PUNCT
admet-280	373	11	b.j	b.j	PROPN
admet-280	373	12	.	.	PROPN
admet-280	373	13	kirby	kirby	PROPN
admet-280	373	14	,	,	PUNCT
admet-280	373	15	d.	d.	PROPN
admet-280	373	16	samineni	samineni	PROPN
admet-280	373	17	,	,	PUNCT
admet-280	373	18	p.b	p.b	PROPN
admet-280	373	19	.	.	PROPN
admet-280	373	20	desai	desai	PROPN
admet-280	373	21	,	,	PUNCT
admet-280	373	22	j.d	j.d	PROPN
admet-280	373	23	.	.	PROPN
admet-280	373	24	unadkat	unadkat	PROPN
admet-280	373	25	,	,	PUNCT
admet-280	373	26	biopharmaceutics	biopharmaceutics	NOUN
admet-280	373	27	&	&	CCONJ
admet-280	373	28	drug	drug	PROPN
admet-280	373	29	disposition	disposition	NOUN
admet-280	373	30	33	33	NUM
admet-280	373	31	(	(	PUNCT
admet-280	373	32	2012	2012	NUM
admet-280	373	33	)	)	PUNCT
admet-280	373	34	207	207	NUM
admet-280	373	35	-	-	SYM
admet-280	373	36	217	217	NUM
admet-280	373	37	.	.	PUNCT
admet-280	374	1	[	[	X
admet-280	374	2	15	15	NUM
admet-280	374	3	]	]	X
admet-280	374	4	g.	g.	PROPN
admet-280	374	5	vogel	vogel	PROPN
admet-280	374	6	,	,	PUNCT
admet-280	374	7	science	science	NOUN
admet-280	374	8	287	287	NUM
admet-280	374	9	(	(	PUNCT
admet-280	374	10	2000	2000	NUM
admet-280	374	11	)	)	PUNCT
admet-280	374	12	948	948	NUM
admet-280	374	13	-	-	SYM
admet-280	374	14	949	949	NUM
admet-280	374	15	.	.	PUNCT
admet-280	375	1	[	[	X
admet-280	375	2	16	16	NUM
admet-280	375	3	]	]	X
admet-280	375	4	n.l	n.l	PROPN
admet-280	375	5	.	.	PROPN
admet-280	375	6	magner	magner	PROPN
admet-280	375	7	,	,	PUNCT
admet-280	375	8	y.	y.	PROPN
admet-280	375	9	jung	jung	PROPN
admet-280	375	10	,	,	PUNCT
admet-280	375	11	j.	j.	PROPN
admet-280	375	12	wu	wu	PROPN
admet-280	375	13	,	,	PUNCT
admet-280	375	14	j.a	j.a	PROPN
admet-280	375	15	.	.	PROPN
admet-280	375	16	nolta	nolta	PROPN
admet-280	375	17	,	,	PUNCT
admet-280	375	18	m.a	m.a	PROPN
admet-280	375	19	.	.	PROPN
admet-280	375	20	zern	zern	PROPN
admet-280	375	21	,	,	PUNCT
admet-280	375	22	p.	p.	NOUN
admet-280	375	23	zhou	zhou	PROPN
admet-280	375	24	,	,	PUNCT
admet-280	375	25	stem	stem	NOUN
admet-280	375	26	cells	cell	NOUN
admet-280	375	27	31	31	NUM
admet-280	375	28	(	(	PUNCT
admet-280	375	29	2013	2013	NUM
admet-280	375	30	)	)	PUNCT
admet-280	375	31	2095	2095	NUM
admet-280	375	32	-	-	SYM
admet-280	375	33	2103	2103	NUM
admet-280	375	34	.	.	PUNCT
admet-280	376	1	[	[	X
admet-280	376	2	17	17	NUM
admet-280	376	3	]	]	X
admet-280	376	4	e.	e.	PROPN
admet-280	376	5	chiao	chiao	PROPN
admet-280	376	6	,	,	PUNCT
admet-280	376	7	m.	m.	NOUN
admet-280	376	8	elazar	elazar	NOUN
admet-280	376	9	,	,	PUNCT
admet-280	376	10	y.	y.	PROPN
admet-280	376	11	xing	xing	PROPN
admet-280	376	12	,	,	PUNCT
admet-280	376	13	a.	a.	PROPN
admet-280	376	14	xiong	xiong	PROPN
admet-280	376	15	,	,	PUNCT
admet-280	376	16	m.	m.	NOUN
admet-280	376	17	kmet	kmet	PROPN
admet-280	376	18	,	,	PUNCT
admet-280	376	19	m.t	m.t	PROPN
admet-280	376	20	.	.	PROPN
admet-280	376	21	millan	millan	PROPN
admet-280	376	22	,	,	PUNCT
admet-280	376	23	j.s	j.s	PROPN
admet-280	376	24	.	.	PROPN
admet-280	376	25	glenn	glenn	PROPN
admet-280	376	26	,	,	PUNCT
admet-280	376	27	w.h	w.h	PROPN
admet-280	376	28	.	.	PROPN
admet-280	376	29	wong	wong	PROPN
admet-280	376	30	,	,	PUNCT
admet-280	376	31	j.	j.	PROPN
admet-280	376	32	baker	baker	PROPN
admet-280	376	33	,	,	PUNCT
admet-280	376	34	stem	stem	VERB
admet-280	376	35	cells	cell	NOUN
admet-280	376	36	26	26	NUM
admet-280	376	37	(	(	PUNCT
admet-280	376	38	2008	2008	NUM
admet-280	376	39	)	)	PUNCT
admet-280	376	40	2032	2032	NUM
admet-280	376	41	-	-	SYM
admet-280	376	42	2041	2041	NUM
admet-280	376	43	.	.	PUNCT
admet-280	377	1	[	[	X
admet-280	377	2	18	18	NUM
admet-280	377	3	]	]	PUNCT
admet-280	377	4	j.	j.	PROPN
admet-280	377	5	cai	cai	PROPN
admet-280	377	6	,	,	PUNCT
admet-280	377	7	y.	y.	PROPN
admet-280	377	8	zhao	zhao	PROPN
admet-280	377	9	,	,	PUNCT
admet-280	377	10	y.	y.	PROPN
admet-280	377	11	liu	liu	PROPN
admet-280	377	12	,	,	PUNCT
admet-280	377	13	f.	f.	PROPN
admet-280	377	14	ye	ye	PROPN
admet-280	377	15	,	,	PUNCT
admet-280	377	16	z.	z.	PROPN
admet-280	377	17	song	song	PROPN
admet-280	377	18	,	,	PUNCT
admet-280	377	19	h.	h.	PROPN
admet-280	377	20	qin	qin	PROPN
admet-280	377	21	,	,	PUNCT
admet-280	377	22	s.	s.	PROPN
admet-280	377	23	meng	meng	PROPN
admet-280	377	24	,	,	PUNCT
admet-280	377	25	y.	y.	PROPN
admet-280	377	26	chen	chen	PROPN
admet-280	377	27	,	,	PUNCT
admet-280	377	28	r.	r.	PROPN
admet-280	377	29	zhou	zhou	PROPN
admet-280	377	30	,	,	PUNCT
admet-280	377	31	x.	x.	NOUN
admet-280	377	32	song	song	PROPN
admet-280	377	33	,	,	PUNCT
admet-280	377	34	y.	y.	PROPN
admet-280	377	35	guo	guo	PROPN
admet-280	377	36	,	,	PUNCT
admet-280	377	37	m.	m.	NOUN
admet-280	377	38	ding	ding	PROPN
admet-280	377	39	,	,	PUNCT
admet-280	377	40	h.	h.	PROPN
admet-280	377	41	deng	deng	PROPN
admet-280	377	42	,	,	PUNCT
admet-280	377	43	hepatology	hepatology	NOUN
admet-280	377	44	45	45	NUM
admet-280	377	45	(	(	PUNCT
admet-280	377	46	2007	2007	NUM
admet-280	377	47	)	)	PUNCT
admet-280	377	48	1229	1229	NUM
admet-280	377	49	-	-	SYM
admet-280	377	50	1239	1239	NUM
admet-280	377	51	.	.	PUNCT
admet-280	378	1	[	[	X
admet-280	378	2	19	19	NUM
admet-280	378	3	]	]	PUNCT
admet-280	378	4	h.	h.	PROPN
admet-280	378	5	basma	basma	PROPN
admet-280	378	6	,	,	PUNCT
admet-280	378	7	a.	a.	PROPN
admet-280	378	8	soto	soto	PROPN
admet-280	378	9	–	–	PUNCT
admet-280	378	10	gutiérrez	gutiérrez	PROPN
admet-280	378	11	,	,	PUNCT
admet-280	378	12	g.r	g.r	PROPN
admet-280	378	13	.	.	PROPN
admet-280	378	14	yannam	yannam	PROPN
admet-280	378	15	,	,	PUNCT
admet-280	378	16	l.	l.	PROPN
admet-280	378	17	liu	liu	PROPN
admet-280	378	18	,	,	PUNCT
admet-280	378	19	r.	r.	PROPN
admet-280	378	20	ito	ito	PROPN
admet-280	378	21	,	,	PUNCT
admet-280	378	22	t.	t.	PROPN
admet-280	378	23	yamamoto	yamamoto	PROPN
admet-280	378	24	,	,	PUNCT
admet-280	378	25	e.	e.	PROPN
admet-280	378	26	ellis	ellis	PROPN
admet-280	378	27	,	,	PUNCT
admet-280	378	28	s.d	s.d	PROPN
admet-280	378	29	.	.	PROPN
admet-280	378	30	carson	carson	PROPN
admet-280	378	31	,	,	PUNCT
admet-280	378	32	s.	s.	PROPN
admet-280	378	33	sato	sato	PROPN
admet-280	378	34	,	,	PUNCT
admet-280	378	35	y.	y.	PROPN
admet-280	378	36	chen	chen	PROPN
admet-280	378	37	,	,	PUNCT
admet-280	378	38	d.	d.	PROPN
admet-280	378	39	muirhead	muirhead	PROPN
admet-280	378	40	,	,	PUNCT
admet-280	378	41	n.	n.	PROPN
admet-280	378	42	navarro	navarro	PROPN
admet-280	378	43	–	–	PUNCT
admet-280	378	44	álvarez	álvarez	PROPN
admet-280	378	45	,	,	PUNCT
admet-280	378	46	r.j	r.j	PROPN
admet-280	378	47	.	.	PROPN
admet-280	378	48	wong	wong	PROPN
admet-280	378	49	,	,	PUNCT
admet-280	378	50	j.	j.	PROPN
admet-280	378	51	roy	roy	PROPN
admet-280	378	52	–	–	PUNCT
admet-280	378	53	chowdhury	chowdhury	PROPN
admet-280	378	54	,	,	PUNCT
admet-280	378	55	j.l	j.l	PROPN
admet-280	378	56	.	.	PROPN
admet-280	378	57	platt	platt	PROPN
admet-280	378	58	,	,	PUNCT
admet-280	378	59	d.f	d.f	PROPN
admet-280	378	60	.	.	PROPN
admet-280	378	61	mercer	mercer	PROPN
admet-280	378	62	,	,	PUNCT
admet-280	378	63	j.d	j.d	PROPN
admet-280	378	64	.	.	PROPN
admet-280	378	65	miller	miller	PROPN
admet-280	378	66	,	,	PUNCT
admet-280	378	67	s.c	s.c	PROPN
admet-280	378	68	.	.	PROPN
admet-280	378	69	strom	strom	PROPN
admet-280	378	70	,	,	PUNCT
admet-280	378	71	n.	n.	PROPN
admet-280	378	72	kobayashi	kobayashi	PROPN
admet-280	378	73	,	,	PUNCT
admet-280	378	74	i.j	i.j	PROPN
admet-280	378	75	.	.	PROPN
admet-280	378	76	fox	fox	PROPN
admet-280	378	77	,	,	PUNCT
admet-280	378	78	gastroenterology	gastroenterology	NOUN
admet-280	378	79	136	136	NUM
admet-280	378	80	(	(	PUNCT
admet-280	378	81	2009	2009	NUM
admet-280	378	82	)	)	PUNCT
admet-280	378	83	990	990	NUM
admet-280	378	84	-	-	SYM
admet-280	378	85	999.e994	999.e994	NUM
admet-280	378	86	.	.	PUNCT
admet-280	379	1	[	[	X
admet-280	379	2	20	20	NUM
admet-280	379	3	]	]	PUNCT
admet-280	379	4	s.	s.	PROPN
admet-280	379	5	agarwal	agarwal	PROPN
admet-280	379	6	,	,	PUNCT
admet-280	379	7	k.l	k.l	PROPN
admet-280	379	8	.	.	PROPN
admet-280	379	9	holton	holton	PROPN
admet-280	379	10	,	,	PUNCT
admet-280	379	11	r.	r.	PROPN
admet-280	379	12	lanza	lanza	PROPN
admet-280	379	13	,	,	PUNCT
admet-280	379	14	stem	stem	NOUN
admet-280	379	15	cells	cell	NOUN
admet-280	379	16	26	26	NUM
admet-280	379	17	(	(	PUNCT
admet-280	379	18	2008	2008	NUM
admet-280	379	19	)	)	PUNCT
admet-280	379	20	1117	1117	NUM
admet-280	379	21	-	-	SYM
admet-280	379	22	1127	1127	NUM
admet-280	379	23	.	.	PUNCT
admet-280	380	1	[	[	X
admet-280	380	2	21	21	NUM
admet-280	380	3	]	]	X
admet-280	380	4	t.n	t.n	PROPN
admet-280	380	5	.	.	PROPN
admet-280	380	6	bukong	bukong	PROPN
admet-280	380	7	,	,	PUNCT
admet-280	380	8	t.	t.	PROPN
admet-280	380	9	lo	lo	PROPN
admet-280	380	10	,	,	PUNCT
admet-280	380	11	g.	g.	PROPN
admet-280	380	12	szabo	szabo	PROPN
admet-280	380	13	,	,	PUNCT
admet-280	380	14	a.	a.	NOUN
admet-280	380	15	dolganiuc	dolganiuc	NOUN
admet-280	380	16	,	,	PUNCT
admet-280	380	17	liver	liver	NOUN
admet-280	380	18	international	international	ADJ
admet-280	380	19	32	32	NUM
admet-280	380	20	(	(	PUNCT
admet-280	380	21	2012	2012	NUM
admet-280	380	22	)	)	PUNCT
admet-280	380	23	732	732	NUM
admet-280	380	24	-	-	SYM
admet-280	380	25	741	741	NUM
admet-280	380	26	.	.	PUNCT
admet-280	381	1	[	[	X
admet-280	381	2	22	22	NUM
admet-280	381	3	]	]	X
admet-280	381	4	y.	y.	PROPN
admet-280	381	5	duan	duan	PROPN
admet-280	381	6	,	,	PUNCT
admet-280	381	7	x.	x.	PROPN
admet-280	381	8	ma	ma	PROPN
admet-280	381	9	,	,	PUNCT
admet-280	381	10	w.	w.	PROPN
admet-280	381	11	zou	zou	PROPN
admet-280	381	12	,	,	PUNCT
admet-280	381	13	c.	c.	PROPN
admet-280	381	14	wang	wang	PROPN
admet-280	381	15	,	,	PUNCT
admet-280	381	16	i.s	i.s	PROPN
admet-280	381	17	.	.	PROPN
admet-280	381	18	bahbahan	bahbahan	PROPN
admet-280	381	19	,	,	PUNCT
admet-280	381	20	t.p	t.p	PROPN
admet-280	381	21	.	.	PROPN
admet-280	381	22	ahuja	ahuja	PROPN
admet-280	381	23	,	,	PUNCT
admet-280	381	24	v.	v.	PROPN
admet-280	381	25	tolstikov	tolstikov	PROPN
admet-280	381	26	,	,	PUNCT
admet-280	381	27	m.a	m.a	PROPN
admet-280	381	28	.	.	PROPN
admet-280	381	29	zern	zern	PROPN
admet-280	381	30	,	,	PUNCT
admet-280	381	31	stem	stem	NOUN
admet-280	381	32	cells	cell	NOUN
admet-280	381	33	28	28	NUM
admet-280	381	34	(	(	PUNCT
admet-280	381	35	2010	2010	NUM
admet-280	381	36	)	)	PUNCT
admet-280	381	37	674	674	NUM
admet-280	381	38	-	-	SYM
admet-280	381	39	686	686	NUM
admet-280	381	40	.	.	PUNCT
admet-280	382	1	[	[	X
admet-280	382	2	23	23	NUM
admet-280	382	3	]	]	PUNCT
admet-280	382	4	m.	m.	NOUN
admet-280	382	5	ghaedi	ghaedi	PROPN
admet-280	382	6	,	,	PUNCT
admet-280	382	7	y.	y.	PROPN
admet-280	382	8	duan	duan	PROPN
admet-280	382	9	,	,	PUNCT
admet-280	382	10	m.a	m.a	PROPN
admet-280	382	11	.	.	PROPN
admet-280	382	12	zern	zern	PROPN
admet-280	382	13	,	,	PUNCT
admet-280	382	14	a.	a.	NOUN
admet-280	382	15	revzin	revzin	NOUN
admet-280	382	16	,	,	PUNCT
admet-280	382	17	journal	journal	NOUN
admet-280	382	18	of	of	ADP
admet-280	382	19	tissue	tissue	NOUN
admet-280	382	20	engineering	engineering	NOUN
admet-280	382	21	and	and	CCONJ
admet-280	382	22	regenerative	regenerative	ADJ
admet-280	382	23	medicine	medicine	NOUN
admet-280	382	24	(	(	PUNCT
admet-280	382	25	2012	2012	NUM
admet-280	382	26	)	)	PUNCT
admet-280	382	27	n	n	CCONJ
admet-280	382	28	/	/	SYM
admet-280	382	29	a	a	PRON
admet-280	382	30	-	-	PUNCT
admet-280	382	31	n	n	CCONJ
admet-280	382	32	/	/	SYM
admet-280	382	33	a.	a.	NOUN
admet-280	383	1	[	[	X
admet-280	383	2	24	24	NUM
admet-280	383	3	]	]	X
admet-280	383	4	d.c	d.c	PROPN
admet-280	383	5	.	.	PUNCT
admet-280	383	6	hay	hay	PROPN
admet-280	383	7	,	,	PUNCT
admet-280	383	8	s.	s.	PROPN
admet-280	383	9	pernagallo	pernagallo	PROPN
admet-280	383	10	,	,	PUNCT
admet-280	383	11	j.j	j.j	PROPN
admet-280	383	12	.	.	PROPN
admet-280	383	13	diaz	diaz	PROPN
admet-280	383	14	-	-	PUNCT
admet-280	383	15	mochon	mochon	PROPN
admet-280	383	16	,	,	PUNCT
admet-280	383	17	c.n	c.n	PROPN
admet-280	383	18	.	.	PROPN
admet-280	383	19	medine	medine	PROPN
admet-280	383	20	,	,	PUNCT
admet-280	383	21	s.	s.	PROPN
admet-280	383	22	greenhough	greenhough	PROPN
admet-280	383	23	,	,	PUNCT
admet-280	383	24	z.	z.	PROPN
admet-280	383	25	hannoun	hannoun	PROPN
admet-280	383	26	,	,	PUNCT
admet-280	383	27	j.	j.	PROPN
admet-280	383	28	schrader	schrader	PROPN
admet-280	383	29	,	,	PUNCT
admet-280	383	30	j.r	j.r	PROPN
admet-280	383	31	.	.	PROPN
admet-280	383	32	black	black	PROPN
admet-280	383	33	,	,	PUNCT
admet-280	383	34	j.	j.	PROPN
admet-280	383	35	fletcher	fletcher	PROPN
admet-280	383	36	,	,	PUNCT
admet-280	383	37	d.	d.	PROPN
admet-280	383	38	dalgetty	dalgetty	PROPN
admet-280	383	39	,	,	PUNCT
admet-280	383	40	a.i	a.i	PROPN
admet-280	383	41	.	.	PROPN
admet-280	383	42	thompson	thompson	PROPN
admet-280	383	43	,	,	PUNCT
admet-280	383	44	p.n	p.n	PROPN
admet-280	383	45	.	.	PROPN
admet-280	383	46	newsome	newsome	PROPN
admet-280	383	47	,	,	PUNCT
admet-280	383	48	s.j	s.j	PROPN
admet-280	383	49	.	.	PROPN
admet-280	383	50	forbes	forbes	PROPN
admet-280	383	51	,	,	PUNCT
admet-280	383	52	j.a	j.a	PROPN
admet-280	383	53	.	.	PROPN
admet-280	383	54	ross	ross	PROPN
admet-280	383	55	,	,	PUNCT
admet-280	383	56	m.	m.	PROPN
admet-280	383	57	bradley	bradley	PROPN
admet-280	383	58	,	,	PUNCT
admet-280	383	59	j.p	j.p	PROPN
admet-280	383	60	.	.	PROPN
admet-280	383	61	iredale	iredale	PROPN
admet-280	383	62	,	,	PUNCT
admet-280	383	63	stem	stem	NOUN
admet-280	383	64	cell	cell	NOUN
admet-280	383	65	research	research	NOUN
admet-280	383	66	6	6	NUM
admet-280	383	67	(	(	PUNCT
admet-280	383	68	2011	2011	NUM
admet-280	383	69	)	)	PUNCT
admet-280	383	70	92	92	NUM
admet-280	383	71	-	-	SYM
admet-280	383	72	102	102	NUM
admet-280	383	73	.	.	PUNCT
admet-280	384	1	voellinger	voellinger	VERB
admet-280	384	2	and	and	CCONJ
admet-280	384	3	kelly	kelly	PROPN
admet-280	384	4	admet	admet	PROPN
admet-280	384	5	&	&	CCONJ
admet-280	384	6	dmpk	dmpk	PROPN
admet-280	384	7	4(2	4(2	NUM
admet-280	384	8	)	)	PUNCT
admet-280	384	9	(	(	PUNCT
admet-280	384	10	2016	2016	NUM
admet-280	384	11	)	)	PUNCT
admet-280	384	12	62	62	NUM
admet-280	384	13	-	-	SYM
admet-280	384	14	83	83	NUM
admet-280	384	15	80	80	NUM
admet-280	385	1	[	[	X
admet-280	385	2	25	25	NUM
admet-280	385	3	]	]	PUNCT
admet-280	385	4	j.	j.	PROPN
admet-280	385	5	heo	heo	PROPN
admet-280	385	6	,	,	PUNCT
admet-280	385	7	e.-k	e.-k	PROPN
admet-280	385	8	.	.	PUNCT
admet-280	386	1	ahn	ahn	PROPN
admet-280	386	2	,	,	PUNCT
admet-280	386	3	h.-g	h.-g	PROPN
admet-280	386	4	.	.	PUNCT
admet-280	387	1	jeong	jeong	PROPN
admet-280	387	2	,	,	PUNCT
admet-280	387	3	y.-h	y.-h	PROPN
admet-280	387	4	.	.	PUNCT
admet-280	388	1	kim	kim	PROPN
admet-280	388	2	,	,	PUNCT
admet-280	388	3	s.-h	s.-h	NOUN
admet-280	388	4	.	.	PUNCT
admet-280	388	5	leem	leem	PROPN
admet-280	388	6	,	,	PUNCT
admet-280	388	7	s.-j	s.-j	PROPN
admet-280	388	8	.	.	PUNCT
admet-280	389	1	lee	lee	PROPN
admet-280	389	2	,	,	PUNCT
admet-280	389	3	e.-k	e.-k	PROPN
admet-280	389	4	.	.	PUNCT
admet-280	390	1	park	park	PROPN
admet-280	390	2	,	,	PUNCT
admet-280	390	3	m.	m.	PROPN
admet-280	390	4	yang	yang	PROPN
admet-280	390	5	,	,	PUNCT
admet-280	390	6	biochemical	biochemical	ADJ
admet-280	390	7	and	and	CCONJ
admet-280	390	8	biophysical	biophysical	ADJ
admet-280	390	9	research	research	NOUN
admet-280	390	10	communications	communication	NOUN
admet-280	390	11	434	434	NUM
admet-280	390	12	(	(	PUNCT
admet-280	390	13	2013	2013	NUM
admet-280	390	14	)	)	PUNCT
admet-280	390	15	235	235	NUM
admet-280	390	16	-	-	SYM
admet-280	390	17	240	240	NUM
admet-280	390	18	.	.	PUNCT
admet-280	391	1	[	[	X
admet-280	391	2	26	26	NUM
admet-280	391	3	]	]	PUNCT
admet-280	391	4	s.	s.	PROPN
admet-280	391	5	ogawa	ogawa	PROPN
admet-280	391	6	,	,	PUNCT
admet-280	391	7	j.	j.	PROPN
admet-280	391	8	surapisitchat	surapisitchat	PROPN
admet-280	391	9	,	,	PUNCT
admet-280	391	10	c.	c.	PROPN
admet-280	391	11	virtanen	virtanen	PROPN
admet-280	391	12	,	,	PUNCT
admet-280	391	13	m.	m.	NOUN
admet-280	391	14	ogawa	ogawa	PROPN
admet-280	391	15	,	,	PUNCT
admet-280	391	16	m.	m.	NOUN
admet-280	391	17	niapour	niapour	PROPN
admet-280	391	18	,	,	PUNCT
admet-280	391	19	k.s	k.s	PROPN
admet-280	391	20	.	.	PROPN
admet-280	391	21	sugamori	sugamori	PROPN
admet-280	391	22	,	,	PUNCT
admet-280	391	23	s.	s.	PROPN
admet-280	391	24	wang	wang	PROPN
admet-280	391	25	,	,	PUNCT
admet-280	391	26	l.	l.	PROPN
admet-280	391	27	tamblyn	tamblyn	PROPN
admet-280	391	28	,	,	PUNCT
admet-280	391	29	c.	c.	PROPN
admet-280	391	30	guillemette	guillemette	PROPN
admet-280	391	31	,	,	PUNCT
admet-280	391	32	e.	e.	PROPN
admet-280	391	33	hoffmann	hoffmann	PROPN
admet-280	391	34	,	,	PUNCT
admet-280	391	35	b.	b.	PROPN
admet-280	391	36	zhao	zhao	PROPN
admet-280	391	37	,	,	PUNCT
admet-280	391	38	s.	s.	PROPN
admet-280	391	39	strom	strom	PROPN
admet-280	391	40	,	,	PUNCT
admet-280	391	41	r.r	r.r	PROPN
admet-280	391	42	.	.	PROPN
admet-280	391	43	laposa	laposa	PROPN
admet-280	391	44	,	,	PUNCT
admet-280	391	45	r.f	r.f	PROPN
admet-280	391	46	.	.	PROPN
admet-280	391	47	tyndale	tyndale	PROPN
admet-280	391	48	,	,	PUNCT
admet-280	391	49	d.m	d.m	PROPN
admet-280	391	50	.	.	PROPN
admet-280	391	51	grant	grant	PROPN
admet-280	391	52	,	,	PUNCT
admet-280	391	53	g.	g.	PROPN
admet-280	391	54	keller	keller	PROPN
admet-280	391	55	,	,	PUNCT
admet-280	391	56	development	development	NOUN
admet-280	391	57	140	140	NUM
admet-280	391	58	(	(	PUNCT
admet-280	391	59	2013	2013	NUM
admet-280	391	60	)	)	PUNCT
admet-280	391	61	3285	3285	NUM
admet-280	391	62	-	-	SYM
admet-280	391	63	3296	3296	NUM
admet-280	391	64	.	.	PUNCT
admet-280	392	1	[	[	X
admet-280	392	2	27	27	NUM
admet-280	392	3	]	]	X
admet-280	392	4	t.s	t.s	PROPN
admet-280	392	5	.	.	PROPN
admet-280	392	6	ramasamy	ramasamy	PROPN
admet-280	392	7	,	,	PUNCT
admet-280	392	8	j.s.l	j.s.l	PROPN
admet-280	392	9	.	.	PUNCT
admet-280	392	10	yu	yu	PROPN
admet-280	392	11	,	,	PUNCT
admet-280	392	12	c.	c.	PROPN
admet-280	392	13	selden	selden	PROPN
admet-280	392	14	,	,	PUNCT
admet-280	392	15	h.	h.	PROPN
admet-280	392	16	hodgson	hodgson	PROPN
admet-280	392	17	,	,	PUNCT
admet-280	392	18	w.	w.	PROPN
admet-280	392	19	cui	cui	PROPN
admet-280	392	20	,	,	PUNCT
admet-280	392	21	tissue	tissue	NOUN
admet-280	392	22	engineering	engineering	NOUN
admet-280	392	23	part	part	NOUN
admet-280	392	24	a	a	DET
admet-280	392	25	19	19	NUM
admet-280	392	26	(	(	PUNCT
admet-280	392	27	2013	2013	NUM
admet-280	392	28	)	)	PUNCT
admet-280	392	29	360	360	NUM
admet-280	392	30	-	-	SYM
admet-280	392	31	367	367	NUM
admet-280	392	32	.	.	PUNCT
admet-280	393	1	[	[	X
admet-280	393	2	28	28	NUM
admet-280	393	3	]	]	X
admet-280	393	4	k.	k.	PROPN
admet-280	393	5	takayama	takayama	PROPN
admet-280	393	6	,	,	PUNCT
admet-280	393	7	m.	m.	NOUN
admet-280	393	8	inamura	inamura	PROPN
admet-280	393	9	,	,	PUNCT
admet-280	393	10	k.	k.	PROPN
admet-280	393	11	kawabata	kawabata	PROPN
admet-280	393	12	,	,	PUNCT
admet-280	393	13	k.	k.	PROPN
admet-280	393	14	katayama	katayama	PROPN
admet-280	393	15	,	,	PUNCT
admet-280	393	16	m.	m.	PROPN
admet-280	393	17	higuchi	higuchi	PROPN
admet-280	393	18	,	,	PUNCT
admet-280	393	19	k.	k.	PROPN
admet-280	393	20	tashiro	tashiro	PROPN
admet-280	393	21	,	,	PUNCT
admet-280	393	22	a.	a.	PROPN
admet-280	393	23	nonaka	nonaka	PROPN
admet-280	393	24	,	,	PUNCT
admet-280	393	25	f.	f.	PROPN
admet-280	393	26	sakurai	sakurai	PROPN
admet-280	393	27	,	,	PUNCT
admet-280	393	28	t.	t.	PROPN
admet-280	393	29	hayakawa	hayakawa	PROPN
admet-280	393	30	,	,	PUNCT
admet-280	393	31	m.	m.	NOUN
admet-280	393	32	kusuda	kusuda	PROPN
admet-280	393	33	furue	furue	PROPN
admet-280	393	34	,	,	PUNCT
admet-280	393	35	h.	h.	PROPN
admet-280	393	36	mizuguchi	mizuguchi	PROPN
admet-280	393	37	,	,	PUNCT
admet-280	393	38	molecular	molecular	ADJ
admet-280	393	39	therapy	therapy	NOUN
admet-280	393	40	20	20	NUM
admet-280	393	41	(	(	PUNCT
admet-280	393	42	2011	2011	NUM
admet-280	393	43	)	)	PUNCT
admet-280	393	44	127	127	NUM
admet-280	393	45	-	-	SYM
admet-280	393	46	137	137	NUM
admet-280	393	47	.	.	PUNCT
admet-280	394	1	[	[	X
admet-280	394	2	29	29	NUM
admet-280	394	3	]	]	PUNCT
admet-280	394	4	k.	k.	PROPN
admet-280	394	5	takayama	takayama	PROPN
admet-280	394	6	,	,	PUNCT
admet-280	394	7	k.	k.	PROPN
admet-280	394	8	kawabata	kawabata	PROPN
admet-280	394	9	,	,	PUNCT
admet-280	394	10	y.	y.	PROPN
admet-280	394	11	nagamoto	nagamoto	PROPN
admet-280	394	12	,	,	PUNCT
admet-280	394	13	k.	k.	PROPN
admet-280	394	14	kishimoto	kishimoto	PROPN
admet-280	394	15	,	,	PUNCT
admet-280	394	16	k.	k.	PROPN
admet-280	394	17	tashiro	tashiro	PROPN
admet-280	394	18	,	,	PUNCT
admet-280	394	19	f.	f.	PROPN
admet-280	394	20	sakurai	sakurai	PROPN
admet-280	394	21	,	,	PUNCT
admet-280	394	22	m.	m.	NOUN
admet-280	394	23	tachibana	tachibana	PROPN
admet-280	394	24	,	,	PUNCT
admet-280	394	25	k.	k.	PROPN
admet-280	394	26	kanda	kanda	PROPN
admet-280	394	27	,	,	PUNCT
admet-280	394	28	t.	t.	PROPN
admet-280	394	29	hayakawa	hayakawa	PROPN
admet-280	394	30	,	,	PUNCT
admet-280	394	31	m.k	m.k	PROPN
admet-280	394	32	.	.	PROPN
admet-280	394	33	furue	furue	PROPN
admet-280	394	34	,	,	PUNCT
admet-280	394	35	h.	h.	PROPN
admet-280	394	36	mizuguchi	mizuguchi	PROPN
admet-280	394	37	,	,	PUNCT
admet-280	394	38	biomaterials	biomaterial	NOUN
admet-280	394	39	34	34	NUM
admet-280	394	40	(	(	PUNCT
admet-280	394	41	2013	2013	NUM
admet-280	394	42	)	)	PUNCT
admet-280	394	43	1781	1781	NUM
admet-280	394	44	-	-	SYM
admet-280	394	45	1789	1789	NUM
admet-280	394	46	.	.	PUNCT
admet-280	395	1	[	[	X
admet-280	395	2	30	30	NUM
admet-280	395	3	]	]	PUNCT
admet-280	395	4	t.	t.	PROPN
admet-280	395	5	touboul	touboul	PROPN
admet-280	395	6	,	,	PUNCT
admet-280	395	7	n.r.f	n.r.f	PROPN
admet-280	395	8	.	.	PUNCT
admet-280	395	9	hannan	hannan	PROPN
admet-280	395	10	,	,	PUNCT
admet-280	395	11	s.	s.	PROPN
admet-280	395	12	corbineau	corbineau	PROPN
admet-280	395	13	,	,	PUNCT
admet-280	395	14	a.	a.	PROPN
admet-280	395	15	martinez	martinez	PROPN
admet-280	395	16	,	,	PUNCT
admet-280	395	17	c.	c.	PROPN
admet-280	395	18	martinet	martinet	PROPN
admet-280	395	19	,	,	PUNCT
admet-280	395	20	s.	s.	PROPN
admet-280	395	21	branchereau	branchereau	PROPN
admet-280	395	22	,	,	PUNCT
admet-280	395	23	s.	s.	PROPN
admet-280	395	24	mainot	mainot	PROPN
admet-280	395	25	,	,	PUNCT
admet-280	395	26	h.	h.	PROPN
admet-280	395	27	strickmarchand	strickmarchand	PROPN
admet-280	395	28	,	,	PUNCT
admet-280	395	29	r.	r.	PROPN
admet-280	395	30	pedersen	pedersen	PROPN
admet-280	395	31	,	,	PUNCT
admet-280	395	32	j.	j.	PROPN
admet-280	395	33	di	di	PROPN
admet-280	395	34	santo	santo	PROPN
admet-280	395	35	,	,	PUNCT
admet-280	395	36	a.	a.	PROPN
admet-280	395	37	weber	weber	PROPN
admet-280	395	38	,	,	PUNCT
admet-280	395	39	l.	l.	PROPN
admet-280	395	40	vallier	vallier	PROPN
admet-280	395	41	,	,	PUNCT
admet-280	395	42	hepatology	hepatology	NOUN
admet-280	395	43	51	51	NUM
admet-280	395	44	(	(	PUNCT
admet-280	395	45	2010	2010	NUM
admet-280	395	46	)	)	PUNCT
admet-280	395	47	1754	1754	NUM
admet-280	395	48	-	-	SYM
admet-280	395	49	1765	1765	NUM
admet-280	395	50	.	.	PUNCT
admet-280	396	1	[	[	X
admet-280	396	2	31	31	NUM
admet-280	396	3	]	]	PUNCT
admet-280	396	4	a.	a.	NOUN
admet-280	396	5	delaforest	delaforest	PROPN
admet-280	396	6	,	,	PUNCT
admet-280	396	7	m.	m.	NOUN
admet-280	396	8	nagaoka	nagaoka	PROPN
admet-280	396	9	,	,	PUNCT
admet-280	396	10	k.	k.	PROPN
admet-280	396	11	si	si	PROPN
admet-280	396	12	-	-	PUNCT
admet-280	396	13	tayeb	tayeb	PROPN
admet-280	396	14	,	,	PUNCT
admet-280	396	15	f.k	f.k	PROPN
admet-280	396	16	.	.	PROPN
admet-280	396	17	noto	noto	PROPN
admet-280	396	18	,	,	PUNCT
admet-280	396	19	g.	g.	PROPN
admet-280	396	20	konopka	konopka	PROPN
admet-280	396	21	,	,	PUNCT
admet-280	396	22	m.a	m.a	PROPN
admet-280	396	23	.	.	PROPN
admet-280	396	24	battle	battle	PROPN
admet-280	396	25	,	,	PUNCT
admet-280	396	26	s.a	s.a	PROPN
admet-280	396	27	.	.	PROPN
admet-280	396	28	duncan	duncan	PROPN
admet-280	396	29	,	,	PUNCT
admet-280	396	30	development	development	NOUN
admet-280	396	31	138	138	NUM
admet-280	396	32	(	(	PUNCT
admet-280	396	33	2011	2011	NUM
admet-280	396	34	)	)	PUNCT
admet-280	396	35	4143	4143	NUM
admet-280	396	36	-	-	SYM
admet-280	396	37	4153	4153	NUM
admet-280	396	38	.	.	PUNCT
admet-280	397	1	[	[	X
admet-280	397	2	32	32	NUM
admet-280	397	3	]	]	X
admet-280	397	4	d.c	d.c	PROPN
admet-280	397	5	.	.	PUNCT
admet-280	397	6	hay	hay	PROPN
admet-280	397	7	,	,	PUNCT
admet-280	397	8	d.	d.	PROPN
admet-280	397	9	zhao	zhao	PROPN
admet-280	397	10	,	,	PUNCT
admet-280	397	11	a.	a.	PROPN
admet-280	397	12	ross	ross	PROPN
admet-280	397	13	,	,	PUNCT
admet-280	397	14	r.	r.	PROPN
admet-280	397	15	mandalam	mandalam	PROPN
admet-280	397	16	,	,	PUNCT
admet-280	397	17	j.	j.	PROPN
admet-280	397	18	lebkowski	lebkowski	PROPN
admet-280	397	19	,	,	PUNCT
admet-280	397	20	w.	w.	PROPN
admet-280	397	21	cui	cui	PROPN
admet-280	397	22	,	,	PUNCT
admet-280	397	23	cloning	cloning	NOUN
admet-280	397	24	and	and	CCONJ
admet-280	397	25	stem	stem	NOUN
admet-280	397	26	cells	cell	NOUN
admet-280	397	27	9	9	NUM
admet-280	397	28	(	(	PUNCT
admet-280	397	29	2007	2007	NUM
admet-280	397	30	)	)	PUNCT
admet-280	397	31	51	51	NUM
admet-280	397	32	-	-	SYM
admet-280	397	33	62	62	NUM
admet-280	397	34	.	.	PUNCT
admet-280	398	1	[	[	X
admet-280	398	2	33	33	NUM
admet-280	398	3	]	]	X
admet-280	398	4	d.c	d.c	PROPN
admet-280	398	5	.	.	PUNCT
admet-280	398	6	hay	hay	PROPN
admet-280	398	7	,	,	PUNCT
admet-280	398	8	d.	d.	PROPN
admet-280	398	9	zhao	zhao	PROPN
admet-280	398	10	,	,	PUNCT
admet-280	398	11	j.	j.	PROPN
admet-280	398	12	fletcher	fletcher	PROPN
admet-280	398	13	,	,	PUNCT
admet-280	398	14	z.a	z.a	PROPN
admet-280	398	15	.	.	PROPN
admet-280	398	16	hewitt	hewitt	PROPN
admet-280	398	17	,	,	PUNCT
admet-280	398	18	d.	d.	PROPN
admet-280	398	19	mclean	mclean	PROPN
admet-280	398	20	,	,	PUNCT
admet-280	398	21	a.	a.	PROPN
admet-280	398	22	urruticoechea	urruticoechea	PROPN
admet-280	398	23	-	-	PUNCT
admet-280	398	24	uriguen	uriguen	PROPN
admet-280	398	25	,	,	PUNCT
admet-280	398	26	j.r	j.r	PROPN
admet-280	398	27	.	.	PROPN
admet-280	398	28	black	black	PROPN
admet-280	398	29	,	,	PUNCT
admet-280	398	30	c.	c.	PROPN
admet-280	398	31	elcombe	elcombe	NOUN
admet-280	398	32	,	,	PUNCT
admet-280	398	33	j.a	j.a	PROPN
admet-280	398	34	.	.	PROPN
admet-280	398	35	ross	ross	PROPN
admet-280	398	36	,	,	PUNCT
admet-280	398	37	r.	r.	PROPN
admet-280	398	38	wolf	wolf	PROPN
admet-280	398	39	,	,	PUNCT
admet-280	398	40	w.	w.	PROPN
admet-280	398	41	cui	cui	PROPN
admet-280	398	42	,	,	PUNCT
admet-280	398	43	stem	stem	NOUN
admet-280	398	44	cells	cell	NOUN
admet-280	398	45	26	26	NUM
admet-280	398	46	(	(	PUNCT
admet-280	398	47	2008	2008	NUM
admet-280	398	48	)	)	PUNCT
admet-280	398	49	894	894	NUM
admet-280	398	50	-	-	SYM
admet-280	398	51	902	902	NUM
admet-280	398	52	.	.	PUNCT
admet-280	399	1	[	[	X
admet-280	399	2	34	34	NUM
admet-280	399	3	]	]	X
admet-280	399	4	l.	l.	PROPN
admet-280	399	5	rambhatla	rambhatla	PROPN
admet-280	399	6	,	,	PUNCT
admet-280	399	7	c.p	c.p	PROPN
admet-280	399	8	.	.	PROPN
admet-280	399	9	chiu	chiu	PROPN
admet-280	399	10	,	,	PUNCT
admet-280	399	11	p.	p.	NOUN
admet-280	399	12	kundu	kundu	NOUN
admet-280	399	13	,	,	PUNCT
admet-280	399	14	y.	y.	PROPN
admet-280	399	15	peng	peng	PROPN
admet-280	399	16	,	,	PUNCT
admet-280	399	17	m.k	m.k	PROPN
admet-280	399	18	.	.	PROPN
admet-280	399	19	carpenter	carpenter	PROPN
admet-280	399	20	,	,	PUNCT
admet-280	399	21	cell	cell	NOUN
admet-280	399	22	transplant	transplant	NOUN
admet-280	399	23	12	12	NUM
admet-280	399	24	(	(	PUNCT
admet-280	399	25	2003	2003	NUM
admet-280	399	26	)	)	PUNCT
admet-280	399	27	1	1	NUM
admet-280	399	28	-	-	SYM
admet-280	399	29	11	11	NUM
admet-280	399	30	.	.	PUNCT
admet-280	400	1	[	[	X
admet-280	400	2	35	35	NUM
admet-280	400	3	]	]	X
admet-280	400	4	d.	d.	PROPN
admet-280	400	5	szkolnicka	szkolnicka	PROPN
admet-280	400	6	,	,	PUNCT
admet-280	400	7	s.l	s.l	PROPN
admet-280	400	8	.	.	PROPN
admet-280	400	9	farnworth	farnworth	PROPN
admet-280	400	10	,	,	PUNCT
admet-280	400	11	b.	b.	PROPN
admet-280	400	12	lucendo	lucendo	PROPN
admet-280	400	13	-	-	PUNCT
admet-280	400	14	villarin	villarin	PROPN
admet-280	400	15	,	,	PUNCT
admet-280	400	16	c.	c.	PROPN
admet-280	400	17	storck	storck	PROPN
admet-280	400	18	,	,	PUNCT
admet-280	400	19	w.	w.	PROPN
admet-280	400	20	zhou	zhou	PROPN
admet-280	400	21	,	,	PUNCT
admet-280	400	22	j.p	j.p	PROPN
admet-280	400	23	.	.	PROPN
admet-280	400	24	iredale	iredale	PROPN
admet-280	400	25	,	,	PUNCT
admet-280	400	26	o.	o.	PROPN
admet-280	400	27	flint	flint	PROPN
admet-280	400	28	,	,	PUNCT
admet-280	400	29	d.c	d.c	PROPN
admet-280	400	30	.	.	PROPN
admet-280	400	31	hay	hay	PROPN
admet-280	400	32	,	,	PUNCT
admet-280	400	33	stem	stem	NOUN
admet-280	400	34	cells	cell	NOUN
admet-280	400	35	transl	transl	X
admet-280	400	36	med	me	VERB
admet-280	400	37	3	3	NUM
admet-280	400	38	(	(	PUNCT
admet-280	400	39	2014	2014	NUM
admet-280	400	40	)	)	PUNCT
admet-280	400	41	141	141	NUM
admet-280	400	42	-	-	SYM
admet-280	400	43	148	148	NUM
admet-280	400	44	.	.	PUNCT
admet-280	401	1	[	[	X
admet-280	401	2	36	36	NUM
admet-280	401	3	]	]	SYM
admet-280	401	4	a.b	a.b	PROPN
admet-280	401	5	.	.	PROPN
admet-280	401	6	mclean	mclean	PROPN
admet-280	401	7	,	,	PUNCT
admet-280	401	8	k.a	k.a	PROPN
admet-280	401	9	.	.	PROPN
admet-280	401	10	d'amour	d'amour	PROPN
admet-280	401	11	,	,	PUNCT
admet-280	401	12	k.l	k.l	PROPN
admet-280	401	13	.	.	PROPN
admet-280	401	14	jones	jones	PROPN
admet-280	401	15	,	,	PUNCT
admet-280	401	16	m.	m.	NOUN
admet-280	401	17	krishnamoorthy	krishnamoorthy	PROPN
admet-280	401	18	,	,	PUNCT
admet-280	401	19	m.j	m.j	PROPN
admet-280	401	20	.	.	PROPN
admet-280	401	21	kulik	kulik	PROPN
admet-280	401	22	,	,	PUNCT
admet-280	401	23	d.m	d.m	PROPN
admet-280	401	24	.	.	PROPN
admet-280	401	25	reynolds	reynolds	PROPN
admet-280	401	26	,	,	PUNCT
admet-280	401	27	a.m.	a.m.	PROPN
admet-280	401	28	sheppard	sheppard	PROPN
admet-280	401	29	,	,	PUNCT
admet-280	401	30	h.	h.	PROPN
admet-280	401	31	liu	liu	PROPN
admet-280	401	32	,	,	PUNCT
admet-280	401	33	y.	y.	PROPN
admet-280	401	34	xu	xu	PROPN
admet-280	401	35	,	,	PUNCT
admet-280	401	36	e.e	e.e	PROPN
admet-280	401	37	.	.	PROPN
admet-280	401	38	baetge	baetge	PROPN
admet-280	401	39	,	,	PUNCT
admet-280	401	40	s.	s.	PROPN
admet-280	401	41	dalton	dalton	PROPN
admet-280	401	42	,	,	PUNCT
admet-280	401	43	stem	stem	NOUN
admet-280	401	44	cells	cell	NOUN
admet-280	401	45	25	25	NUM
admet-280	401	46	(	(	PUNCT
admet-280	401	47	2007	2007	NUM
admet-280	401	48	)	)	PUNCT
admet-280	401	49	29	29	NUM
admet-280	401	50	-	-	SYM
admet-280	401	51	38	38	NUM
admet-280	401	52	.	.	PUNCT
admet-280	402	1	[	[	X
admet-280	402	2	37	37	NUM
admet-280	402	3	]	]	PUNCT
admet-280	402	4	p.	p.	NOUN
admet-280	402	5	gripon	gripon	PROPN
admet-280	402	6	,	,	PUNCT
admet-280	402	7	s.	s.	PROPN
admet-280	402	8	rumin	rumin	PROPN
admet-280	402	9	,	,	PUNCT
admet-280	402	10	s.	s.	PROPN
admet-280	402	11	urban	urban	PROPN
admet-280	402	12	,	,	PUNCT
admet-280	402	13	j.	j.	PROPN
admet-280	402	14	le	le	PROPN
admet-280	402	15	seyec	seyec	PROPN
admet-280	402	16	,	,	PUNCT
admet-280	402	17	d.	d.	PROPN
admet-280	402	18	glaise	glaise	PROPN
admet-280	402	19	,	,	PUNCT
admet-280	402	20	i.	i.	PROPN
admet-280	402	21	cannie	cannie	PROPN
admet-280	402	22	,	,	PUNCT
admet-280	402	23	c.	c.	PROPN
admet-280	402	24	guyomard	guyomard	PROPN
admet-280	402	25	,	,	PUNCT
admet-280	402	26	j.	j.	PROPN
admet-280	402	27	lucas	lucas	PROPN
admet-280	402	28	,	,	PUNCT
admet-280	402	29	c.	c.	PROPN
admet-280	402	30	trepo	trepo	PROPN
admet-280	402	31	,	,	PUNCT
admet-280	402	32	c.	c.	PROPN
admet-280	402	33	guguen	guguen	PROPN
admet-280	402	34	-	-	PUNCT
admet-280	402	35	guillouzo	guillouzo	PROPN
admet-280	402	36	,	,	PUNCT
admet-280	402	37	proceedings	proceeding	NOUN
admet-280	402	38	of	of	ADP
admet-280	402	39	the	the	DET
admet-280	402	40	national	national	PROPN
admet-280	402	41	academy	academy	PROPN
admet-280	402	42	of	of	ADP
admet-280	402	43	sciences	sciences	PROPN
admet-280	402	44	of	of	ADP
admet-280	402	45	the	the	DET
admet-280	402	46	united	united	PROPN
admet-280	402	47	states	states	PROPN
admet-280	402	48	of	of	ADP
admet-280	402	49	america	america	PROPN
admet-280	402	50	99	99	NUM
admet-280	402	51	(	(	PUNCT
admet-280	402	52	2002	2002	NUM
admet-280	402	53	)	)	PUNCT
admet-280	402	54	15655	15655	NUM
admet-280	402	55	-	-	SYM
admet-280	402	56	15660	15660	NUM
admet-280	402	57	.	.	PUNCT
admet-280	403	1	[	[	X
admet-280	403	2	38	38	NUM
admet-280	403	3	]	]	PUNCT
admet-280	403	4	c.	c.	NOUN
admet-280	403	5	aninat	aninat	NOUN
admet-280	403	6	,	,	PUNCT
admet-280	403	7	a.	a.	PROPN
admet-280	403	8	piton	piton	PROPN
admet-280	403	9	,	,	PUNCT
admet-280	403	10	d.	d.	PROPN
admet-280	403	11	glaise	glaise	PROPN
admet-280	403	12	,	,	PUNCT
admet-280	403	13	t.	t.	PROPN
admet-280	403	14	le	le	PROPN
admet-280	403	15	charpentier	charpentier	PROPN
admet-280	403	16	,	,	PUNCT
admet-280	403	17	s.	s.	PROPN
admet-280	403	18	langouet	langouet	PROPN
admet-280	403	19	,	,	PUNCT
admet-280	403	20	f.	f.	PROPN
admet-280	403	21	morel	morel	PROPN
admet-280	403	22	,	,	PUNCT
admet-280	403	23	c.	c.	PROPN
admet-280	403	24	guguen	guguen	PROPN
admet-280	403	25	-	-	PUNCT
admet-280	403	26	guillouzo	guillouzo	PROPN
admet-280	403	27	,	,	PUNCT
admet-280	403	28	a.	a.	NOUN
admet-280	403	29	guillouzo	guillouzo	PROPN
admet-280	403	30	,	,	PUNCT
admet-280	403	31	drug	drug	NOUN
admet-280	403	32	metabolism	metabolism	NOUN
admet-280	403	33	and	and	CCONJ
admet-280	403	34	disposition	disposition	NOUN
admet-280	403	35	:	:	PUNCT
admet-280	403	36	the	the	DET
admet-280	403	37	biological	biological	ADJ
admet-280	403	38	fate	fate	NOUN
admet-280	403	39	of	of	ADP
admet-280	403	40	chemicals	chemical	NOUN
admet-280	403	41	34	34	NUM
admet-280	403	42	(	(	PUNCT
admet-280	403	43	2006	2006	NUM
admet-280	403	44	)	)	PUNCT
admet-280	403	45	75	75	NUM
admet-280	403	46	-	-	SYM
admet-280	403	47	83	83	NUM
admet-280	403	48	.	.	PUNCT
admet-280	404	1	[	[	X
admet-280	404	2	39	39	NUM
admet-280	404	3	]	]	X
admet-280	404	4	s.n	s.n	PROPN
admet-280	404	5	.	.	PROPN
admet-280	404	6	hart	hart	PROPN
admet-280	404	7	,	,	PUNCT
admet-280	404	8	y.	y.	PROPN
admet-280	404	9	li	li	PROPN
admet-280	404	10	,	,	PUNCT
admet-280	404	11	k.	k.	PROPN
admet-280	404	12	nakamoto	nakamoto	PROPN
admet-280	404	13	,	,	PUNCT
admet-280	404	14	e.a	e.a	PROPN
admet-280	404	15	.	.	PROPN
admet-280	404	16	subileau	subileau	PROPN
admet-280	404	17	,	,	PUNCT
admet-280	404	18	d.	d.	PROPN
admet-280	404	19	steen	steen	PROPN
admet-280	404	20	,	,	PUNCT
admet-280	404	21	x.b	x.b	PROPN
admet-280	404	22	.	.	PROPN
admet-280	404	23	zhong	zhong	PROPN
admet-280	404	24	,	,	PUNCT
admet-280	404	25	drug	drug	NOUN
admet-280	404	26	metabolism	metabolism	NOUN
admet-280	404	27	and	and	CCONJ
admet-280	404	28	disposition	disposition	NOUN
admet-280	404	29	:	:	PUNCT
admet-280	404	30	the	the	DET
admet-280	404	31	biological	biological	ADJ
admet-280	404	32	fate	fate	NOUN
admet-280	404	33	of	of	ADP
admet-280	404	34	chemicals	chemical	NOUN
admet-280	404	35	38	38	NUM
admet-280	404	36	(	(	PUNCT
admet-280	404	37	2010	2010	NUM
admet-280	404	38	)	)	PUNCT
admet-280	404	39	988	988	NUM
admet-280	404	40	-	-	SYM
admet-280	404	41	994	994	NUM
admet-280	404	42	.	.	PUNCT
admet-280	405	1	[	[	X
admet-280	405	2	40	40	NUM
admet-280	405	3	]	]	PUNCT
admet-280	405	4	h.	h.	PROPN
admet-280	405	5	li	li	PROPN
admet-280	405	6	,	,	PUNCT
admet-280	405	7	h.	h.	PROPN
admet-280	405	8	wang	wang	PROPN
admet-280	405	9	,	,	PUNCT
admet-280	405	10	expert	expert	NOUN
admet-280	405	11	opin	opin	NOUN
admet-280	405	12	drug	drug	NOUN
admet-280	405	13	metab	metab	NOUN
admet-280	405	14	toxicol	toxicol	NOUN
admet-280	405	15	6	6	NUM
admet-280	405	16	(	(	PUNCT
admet-280	405	17	2010	2010	NUM
admet-280	405	18	)	)	PUNCT
admet-280	405	19	409	409	NUM
admet-280	405	20	-	-	SYM
admet-280	405	21	426	426	NUM
admet-280	405	22	.	.	PUNCT
admet-280	406	1	[	[	X
admet-280	406	2	41	41	NUM
admet-280	406	3	]	]	X
admet-280	406	4	a.h	a.h	PROPN
admet-280	406	5	.	.	PROPN
admet-280	406	6	tolson	tolson	PROPN
admet-280	406	7	,	,	PUNCT
admet-280	406	8	h.	h.	PROPN
admet-280	406	9	wang	wang	PROPN
admet-280	406	10	,	,	PUNCT
admet-280	406	11	adv	adv	PROPN
admet-280	406	12	drug	drug	NOUN
admet-280	406	13	deliv	deliv	NOUN
admet-280	406	14	rev	rev	VERB
admet-280	406	15	62	62	NUM
admet-280	406	16	(	(	PUNCT
admet-280	406	17	2010	2010	NUM
admet-280	406	18	)	)	PUNCT
admet-280	406	19	1238	1238	NUM
admet-280	406	20	-	-	SYM
admet-280	406	21	1249	1249	NUM
admet-280	406	22	.	.	PUNCT
admet-280	407	1	[	[	X
admet-280	407	2	42	42	NUM
admet-280	407	3	]	]	PUNCT
admet-280	407	4	r.	r.	PROPN
admet-280	407	5	jover	jover	PROPN
admet-280	407	6	,	,	PUNCT
admet-280	407	7	r.	r.	PROPN
admet-280	407	8	bort	bort	PROPN
admet-280	407	9	,	,	PUNCT
admet-280	407	10	m.j	m.j	PROPN
admet-280	407	11	.	.	PROPN
admet-280	407	12	gomez	gomez	PROPN
admet-280	407	13	-	-	PUNCT
admet-280	407	14	lechon	lechon	NOUN
admet-280	407	15	,	,	PUNCT
admet-280	407	16	j.v	j.v	PROPN
admet-280	407	17	.	.	PROPN
admet-280	407	18	castell	castell	PROPN
admet-280	407	19	,	,	PUNCT
admet-280	407	20	hepatology	hepatology	NOUN
admet-280	407	21	33	33	NUM
admet-280	407	22	(	(	PUNCT
admet-280	407	23	2001	2001	NUM
admet-280	407	24	)	)	PUNCT
admet-280	407	25	668	668	NUM
admet-280	407	26	-	-	SYM
admet-280	407	27	675	675	NUM
admet-280	407	28	.	.	PUNCT
admet-280	408	1	[	[	X
admet-280	408	2	43	43	NUM
admet-280	408	3	]	]	X
admet-280	408	4	c.e	c.e	PROPN
admet-280	408	5	.	.	PROPN
admet-280	408	6	fluck	fluck	PROPN
admet-280	408	7	,	,	PUNCT
admet-280	408	8	p.e	p.e	PROPN
admet-280	408	9	.	.	PROPN
admet-280	408	10	mullis	mullis	PROPN
admet-280	408	11	,	,	PUNCT
admet-280	408	12	a.v	a.v	PROPN
admet-280	408	13	.	.	PROPN
admet-280	408	14	pandey	pandey	PROPN
admet-280	408	15	,	,	PUNCT
admet-280	408	16	biochem	biochem	PROPN
admet-280	408	17	biophys	biophy	VERB
admet-280	408	18	res	re	NOUN
admet-280	408	19	commun	commun	PROPN
admet-280	408	20	401	401	NUM
admet-280	408	21	(	(	PUNCT
admet-280	408	22	2010	2010	NUM
admet-280	408	23	)	)	PUNCT
admet-280	408	24	149	149	NUM
admet-280	408	25	-	-	SYM
admet-280	408	26	153	153	NUM
admet-280	408	27	.	.	PUNCT
admet-280	409	1	[	[	X
admet-280	409	2	44	44	NUM
admet-280	409	3	]	]	X
admet-280	409	4	a.v	a.v	PROPN
admet-280	409	5	.	.	PROPN
admet-280	409	6	pandey	pandey	PROPN
admet-280	409	7	,	,	PUNCT
admet-280	409	8	c.e	c.e	PROPN
admet-280	409	9	.	.	PROPN
admet-280	409	10	fluck	fluck	PROPN
admet-280	409	11	,	,	PUNCT
admet-280	409	12	pharmacology	pharmacology	NOUN
admet-280	409	13	&	&	CCONJ
admet-280	409	14	therapeutics	therapeutic	NOUN
admet-280	409	15	138	138	NUM
admet-280	409	16	(	(	PUNCT
admet-280	409	17	2013	2013	NUM
admet-280	409	18	)	)	PUNCT
admet-280	409	19	229	229	NUM
admet-280	409	20	-	-	SYM
admet-280	409	21	254	254	NUM
admet-280	409	22	.	.	PUNCT
admet-280	410	1	[	[	X
admet-280	410	2	45	45	NUM
admet-280	410	3	]	]	X
admet-280	410	4	s.	s.	PROPN
admet-280	410	5	langton	langton	PROPN
admet-280	410	6	,	,	PUNCT
admet-280	410	7	l.j	l.j	PROPN
admet-280	410	8	.	.	PROPN
admet-280	410	9	gudas	gudas	PROPN
admet-280	410	10	,	,	PUNCT
admet-280	410	11	dev	dev	PROPN
admet-280	410	12	biol	biol	PROPN
admet-280	410	13	315	315	NUM
admet-280	410	14	(	(	PUNCT
admet-280	410	15	2008	2008	NUM
admet-280	410	16	)	)	PUNCT
admet-280	410	17	331	331	NUM
admet-280	410	18	-	-	SYM
admet-280	410	19	354	354	NUM
admet-280	410	20	.	.	PUNCT
admet-280	411	1	[	[	X
admet-280	411	2	46	46	NUM
admet-280	411	3	]	]	X
admet-280	411	4	l.j	l.j	PROPN
admet-280	411	5	.	.	PROPN
admet-280	411	6	gudas	gudas	PROPN
admet-280	411	7	,	,	PUNCT
admet-280	411	8	j.a	j.a	PROPN
admet-280	411	9	.	.	PROPN
admet-280	411	10	wagner	wagner	PROPN
admet-280	411	11	,	,	PUNCT
admet-280	411	12	j	j	PROPN
admet-280	411	13	cell	cell	NOUN
admet-280	411	14	physiol	physiol	PROPN
admet-280	411	15	226	226	NUM
admet-280	411	16	(	(	PUNCT
admet-280	411	17	2011	2011	NUM
admet-280	411	18	)	)	PUNCT
admet-280	411	19	322	322	NUM
admet-280	411	20	-	-	SYM
admet-280	411	21	330	330	NUM
admet-280	411	22	.	.	PUNCT
admet-280	412	1	[	[	X
admet-280	412	2	47	47	NUM
admet-280	412	3	]	]	PUNCT
admet-280	412	4	s.	s.	PROPN
admet-280	412	5	lutsenko	lutsenko	PROPN
admet-280	412	6	,	,	PUNCT
admet-280	412	7	r.g	r.g	PROPN
admet-280	412	8	.	.	PROPN
admet-280	412	9	efremov	efremov	PROPN
admet-280	412	10	,	,	PUNCT
admet-280	412	11	r.	r.	PROPN
admet-280	412	12	tsivkovskii	tsivkovskii	PROPN
admet-280	412	13	,	,	PUNCT
admet-280	412	14	j.m	j.m	PROPN
admet-280	412	15	.	.	PROPN
admet-280	412	16	walker	walker	PROPN
admet-280	412	17	,	,	PUNCT
admet-280	412	18	j	j	PROPN
admet-280	412	19	bioenerg	bioenerg	PROPN
admet-280	412	20	biomembr	biomembr	VERB
admet-280	412	21	34	34	NUM
admet-280	412	22	(	(	PUNCT
admet-280	412	23	2002	2002	NUM
admet-280	412	24	)	)	PUNCT
admet-280	412	25	351	351	NUM
admet-280	412	26	-	-	SYM
admet-280	412	27	362	362	NUM
admet-280	412	28	.	.	PUNCT
admet-280	413	1	[	[	X
admet-280	413	2	48	48	NUM
admet-280	413	3	]	]	PUNCT
admet-280	413	4	m.	m.	NOUN
admet-280	413	5	ingelman	ingelman	NOUN
admet-280	413	6	-	-	PUNCT
admet-280	413	7	sundberg	sundberg	PROPN
admet-280	413	8	,	,	PUNCT
admet-280	413	9	s.c	s.c	PROPN
admet-280	413	10	.	.	PROPN
admet-280	413	11	sim	sim	PROPN
admet-280	413	12	,	,	PUNCT
admet-280	413	13	a.	a.	PROPN
admet-280	413	14	gomez	gomez	PROPN
admet-280	413	15	,	,	PUNCT
admet-280	413	16	c.	c.	PROPN
admet-280	413	17	rodriguez	rodriguez	PROPN
admet-280	413	18	-	-	PUNCT
admet-280	413	19	antona	antona	NOUN
admet-280	413	20	,	,	PUNCT
admet-280	413	21	pharmacology	pharmacology	NOUN
admet-280	413	22	&	&	CCONJ
admet-280	413	23	therapeutics	therapeutic	NOUN
admet-280	413	24	116	116	NUM
admet-280	413	25	(	(	PUNCT
admet-280	413	26	2007	2007	NUM
admet-280	413	27	)	)	PUNCT
admet-280	413	28	496	496	NUM
admet-280	413	29	-	-	SYM
admet-280	413	30	526	526	NUM
admet-280	413	31	.	.	PUNCT
admet-280	414	1	[	[	X
admet-280	414	2	49	49	NUM
admet-280	414	3	]	]	PUNCT
admet-280	414	4	h.	h.	PROPN
admet-280	414	5	smith	smith	PROPN
admet-280	414	6	,	,	PUNCT
admet-280	414	7	eaton	eaton	PROPN
admet-280	414	8	,	,	PUNCT
admet-280	414	9	dl	dl	PROPN
admet-280	414	10	,	,	PUNCT
admet-280	414	11	bammler	bammler	NOUN
admet-280	414	12	,	,	PUNCT
admet-280	414	13	tk	tk	PROPN
admet-280	414	14	,	,	PUNCT
admet-280	414	15	polymorphisms	polymorphism	NOUN
admet-280	414	16	in	in	ADP
admet-280	414	17	xenobiotic	xenobiotic	ADJ
admet-280	414	18	conjugation	conjugation	NOUN
admet-280	414	19	,	,	PUNCT
admet-280	414	20	in	in	ADP
admet-280	414	21	:	:	PUNCT
admet-280	414	22	l.	l.	PROPN
admet-280	414	23	costa	costa	PROPN
admet-280	414	24	,	,	PUNCT
admet-280	414	25	eaton	eaton	PROPN
admet-280	414	26	,	,	PUNCT
admet-280	414	27	dl	dl	PROPN
admet-280	414	28	(	(	PUNCT
admet-280	414	29	ed	ed	NOUN
admet-280	414	30	.	.	PUNCT
admet-280	414	31	)	)	PUNCT
admet-280	415	1	gene	gene	NOUN
admet-280	415	2	-	-	PUNCT
admet-280	415	3	environment	environment	NOUN
admet-280	415	4	interactions	interaction	NOUN
admet-280	415	5	:	:	PUNCT
admet-280	415	6	the	the	DET
admet-280	415	7	fundamentals	fundamental	NOUN
admet-280	415	8	of	of	ADP
admet-280	415	9	ecogenetics	ecogenetic	NOUN
admet-280	415	10	,	,	PUNCT
admet-280	415	11	wiley	wiley	PROPN
admet-280	415	12	press	press	PROPN
admet-280	415	13	,	,	PUNCT
admet-280	415	14	new	new	PROPN
admet-280	415	15	york	york	PROPN
admet-280	415	16	,	,	PUNCT
admet-280	415	17	2006	2006	NUM
admet-280	415	18	,	,	PUNCT
admet-280	415	19	pp	pp	ADV
admet-280	415	20	.	.	PUNCT
admet-280	416	1	127	127	NUM
admet-280	416	2	-	-	SYM
admet-280	416	3	158	158	NUM
admet-280	416	4	.	.	PUNCT
admet-280	417	1	[	[	X
admet-280	417	2	50	50	NUM
admet-280	417	3	]	]	X
admet-280	417	4	j.m	j.m	PROPN
admet-280	417	5	.	.	PROPN
admet-280	417	6	hoskins	hoskins	PROPN
admet-280	417	7	,	,	PUNCT
admet-280	417	8	r.m	r.m	PROPN
admet-280	417	9	.	.	PROPN
admet-280	417	10	goldberg	goldberg	PROPN
admet-280	417	11	,	,	PUNCT
admet-280	417	12	p.	p.	PROPN
admet-280	417	13	qu	qu	PROPN
admet-280	417	14	,	,	PUNCT
admet-280	417	15	j.g	j.g	PROPN
admet-280	417	16	.	.	PROPN
admet-280	417	17	ibrahim	ibrahim	PROPN
admet-280	417	18	,	,	PUNCT
admet-280	417	19	h.l	h.l	PROPN
admet-280	417	20	.	.	PROPN
admet-280	417	21	mcleod	mcleod	PROPN
admet-280	417	22	,	,	PUNCT
admet-280	417	23	jnci	jnci	PROPN
admet-280	417	24	journal	journal	PROPN
admet-280	417	25	of	of	ADP
admet-280	417	26	the	the	DET
admet-280	417	27	national	national	PROPN
admet-280	417	28	cancer	cancer	PROPN
admet-280	417	29	institute	institute	PROPN
admet-280	417	30	99	99	NUM
admet-280	417	31	(	(	PUNCT
admet-280	417	32	2007	2007	NUM
admet-280	417	33	)	)	PUNCT
admet-280	417	34	1290	1290	NUM
admet-280	417	35	-	-	SYM
admet-280	417	36	1295	1295	NUM
admet-280	417	37	.	.	PUNCT
admet-280	418	1	[	[	X
admet-280	418	2	51	51	NUM
admet-280	418	3	]	]	X
admet-280	418	4	y.	y.	PROPN
admet-280	418	5	duan	duan	PROPN
admet-280	418	6	,	,	PUNCT
admet-280	418	7	a.	a.	PROPN
admet-280	418	8	catana	catana	PROPN
admet-280	418	9	,	,	PUNCT
admet-280	418	10	y.	y.	PROPN
admet-280	418	11	meng	meng	PROPN
admet-280	418	12	,	,	PUNCT
admet-280	418	13	n.	n.	PROPN
admet-280	418	14	yamamoto	yamamoto	PROPN
admet-280	418	15	,	,	PUNCT
admet-280	418	16	s.	s.	PROPN
admet-280	418	17	he	he	PRON
admet-280	418	18	,	,	PUNCT
admet-280	418	19	s.	s.	PROPN
admet-280	418	20	gupta	gupta	PROPN
admet-280	418	21	,	,	PUNCT
admet-280	418	22	s.s	s.s	PROPN
admet-280	418	23	.	.	PROPN
admet-280	418	24	gambhir	gambhir	PROPN
admet-280	418	25	,	,	PUNCT
admet-280	418	26	m.a	m.a	PROPN
admet-280	418	27	.	.	PROPN
admet-280	418	28	zern	zern	PROPN
admet-280	418	29	,	,	PUNCT
admet-280	418	30	stem	stem	NOUN
admet-280	418	31	cells	cell	NOUN
admet-280	418	32	25	25	NUM
admet-280	418	33	(	(	PUNCT
admet-280	418	34	2007	2007	NUM
admet-280	418	35	)	)	PUNCT
admet-280	418	36	3058	3058	NUM
admet-280	418	37	-	-	SYM
admet-280	418	38	3068	3068	NUM
admet-280	418	39	.	.	PUNCT
admet-280	419	1	[	[	X
admet-280	419	2	52	52	NUM
admet-280	419	3	]	]	PUNCT
admet-280	419	4	m.	m.	NOUN
admet-280	419	5	ek	ek	PROPN
admet-280	419	6	,	,	PUNCT
admet-280	419	7	t.	t.	PROPN
admet-280	419	8	söderdahl	söderdahl	PROPN
admet-280	419	9	,	,	PUNCT
admet-280	419	10	b.	b.	PROPN
admet-280	419	11	küppers	küppers	PROPN
admet-280	419	12	-	-	PUNCT
admet-280	419	13	munther	munther	NOUN
admet-280	419	14	,	,	PUNCT
admet-280	419	15	j.	j.	PROPN
admet-280	419	16	edsbagge	edsbagge	PROPN
admet-280	419	17	,	,	PUNCT
admet-280	419	18	t.b	t.b	PROPN
admet-280	419	19	.	.	PROPN
admet-280	419	20	andersson	andersson	PROPN
admet-280	419	21	,	,	PUNCT
admet-280	419	22	p.	p.	PROPN
admet-280	419	23	björquist	björquist	PROPN
admet-280	419	24	,	,	PUNCT
admet-280	419	25	i.	i.	NOUN
admet-280	419	26	cotgreave	cotgreave	PROPN
admet-280	419	27	,	,	PUNCT
admet-280	419	28	b.	b.	PROPN
admet-280	419	29	jernström	jernström	PROPN
admet-280	419	30	,	,	PUNCT
admet-280	419	31	m.	m.	NOUN
admet-280	419	32	ingelman	ingelman	NOUN
admet-280	419	33	-	-	PUNCT
admet-280	419	34	sundberg	sundberg	PROPN
admet-280	419	35	,	,	PUNCT
admet-280	419	36	i.	i.	PROPN
admet-280	419	37	johansson	johansson	PROPN
admet-280	419	38	,	,	PUNCT
admet-280	419	39	biochemical	biochemical	ADJ
admet-280	419	40	pharmacology	pharmacology	NOUN
admet-280	419	41	74	74	NUM
admet-280	419	42	(	(	PUNCT
admet-280	419	43	2007	2007	NUM
admet-280	419	44	)	)	PUNCT
admet-280	419	45	496	496	NUM
admet-280	419	46	-	-	SYM
admet-280	419	47	503	503	NUM
admet-280	419	48	.	.	PUNCT
admet-280	419	49	admet	admet	PROPN
admet-280	419	50	&	&	CCONJ
admet-280	419	51	dmpk	dmpk	PROPN
admet-280	419	52	4(2	4(2	NUM
admet-280	419	53	)	)	PUNCT
admet-280	419	54	(	(	PUNCT
admet-280	419	55	2016	2016	NUM
admet-280	419	56	)	)	PUNCT
admet-280	419	57	62	62	NUM
admet-280	419	58	-	-	SYM
admet-280	419	59	83	83	NUM
admet-280	419	60	pharmacogenetics	pharmacogenetic	NOUN
admet-280	419	61	and	and	CCONJ
admet-280	419	62	cyp	cyp	ADJ
admet-280	419	63	activity	activity	NOUN
admet-280	419	64	doi	doi	NOUN
admet-280	419	65	:	:	PUNCT
admet-280	419	66	10.5599	10.5599	NUM
admet-280	419	67	/	/	SYM
admet-280	419	68	admet.4.2.280	admet.4.2.280	NUM
admet-280	419	69	81	81	NUM
admet-280	419	70	[	[	X
admet-280	419	71	53	53	NUM
admet-280	419	72	]	]	X
admet-280	419	73	r.	r.	PROPN
admet-280	419	74	ghotbi	ghotbi	PROPN
admet-280	419	75	,	,	PUNCT
admet-280	419	76	m.	m.	NOUN
admet-280	419	77	christensen	christensen	PROPN
admet-280	419	78	,	,	PUNCT
admet-280	419	79	h.-k	h.-k	PROPN
admet-280	419	80	.	.	PUNCT
admet-280	420	1	roh	roh	PROPN
admet-280	420	2	,	,	PUNCT
admet-280	420	3	m.	m.	NOUN
admet-280	420	4	ingelman	ingelman	NOUN
admet-280	420	5	-	-	PUNCT
admet-280	420	6	sundberg	sundberg	PROPN
admet-280	420	7	,	,	PUNCT
admet-280	420	8	e.	e.	PROPN
admet-280	420	9	aklillu	aklillu	PROPN
admet-280	420	10	,	,	PUNCT
admet-280	420	11	l.	l.	PROPN
admet-280	420	12	bertilsson	bertilsson	PROPN
admet-280	420	13	,	,	PUNCT
admet-280	420	14	european	european	PROPN
admet-280	420	15	journal	journal	PROPN
admet-280	420	16	of	of	ADP
admet-280	420	17	clinical	clinical	ADJ
admet-280	420	18	pharmacology	pharmacology	NOUN
admet-280	420	19	63	63	NUM
admet-280	420	20	(	(	PUNCT
admet-280	420	21	2007	2007	NUM
admet-280	420	22	)	)	PUNCT
admet-280	420	23	537	537	NUM
admet-280	420	24	-	-	SYM
admet-280	420	25	546	546	NUM
admet-280	420	26	.	.	PUNCT
admet-280	421	1	[	[	X
admet-280	421	2	54	54	NUM
admet-280	421	3	]	]	PUNCT
admet-280	421	4	s.	s.	PROPN
admet-280	421	5	raimundo	raimundo	PROPN
admet-280	421	6	,	,	PUNCT
admet-280	421	7	clinical	clinical	ADJ
admet-280	421	8	pharmacology	pharmacology	NOUN
admet-280	421	9	&	&	CCONJ
admet-280	421	10	therapeutics	therapeutic	NOUN
admet-280	421	11	76	76	NUM
admet-280	421	12	(	(	PUNCT
admet-280	421	13	2004	2004	NUM
admet-280	421	14	)	)	PUNCT
admet-280	421	15	128	128	NUM
admet-280	421	16	-	-	SYM
admet-280	421	17	138	138	NUM
admet-280	421	18	.	.	PUNCT
admet-280	422	1	[	[	X
admet-280	422	2	55	55	NUM
admet-280	422	3	]	]	X
admet-280	422	4	c.	c.	PROPN
admet-280	422	5	toscano	toscano	PROPN
admet-280	422	6	,	,	PUNCT
admet-280	422	7	k.	k.	PROPN
admet-280	422	8	klein	klein	PROPN
admet-280	422	9	,	,	PUNCT
admet-280	422	10	j.	j.	PROPN
admet-280	422	11	blievernicht	blievernicht	PROPN
admet-280	422	12	,	,	PUNCT
admet-280	422	13	e.	e.	PROPN
admet-280	422	14	schaeffeler	schaeffeler	PROPN
admet-280	422	15	,	,	PUNCT
admet-280	422	16	t.	t.	PROPN
admet-280	422	17	saussele	saussele	PROPN
admet-280	422	18	,	,	PUNCT
admet-280	422	19	s.	s.	PROPN
admet-280	422	20	raimundo	raimundo	PROPN
admet-280	422	21	,	,	PUNCT
admet-280	422	22	m.	m.	NOUN
admet-280	422	23	eichelbaum	eichelbaum	PROPN
admet-280	422	24	,	,	PUNCT
admet-280	422	25	m.	m.	NOUN
admet-280	422	26	schwab	schwab	PROPN
admet-280	422	27	,	,	PUNCT
admet-280	422	28	u.m	u.m	PROPN
admet-280	422	29	.	.	PROPN
admet-280	422	30	zanger	zanger	NOUN
admet-280	422	31	,	,	PUNCT
admet-280	422	32	pharmacogenet	pharmacogenet	NOUN
admet-280	422	33	genomics	genomic	NOUN
admet-280	422	34	16	16	NUM
admet-280	422	35	(	(	PUNCT
admet-280	422	36	2006	2006	NUM
admet-280	422	37	)	)	PUNCT
admet-280	422	38	755	755	NUM
admet-280	422	39	-	-	SYM
admet-280	422	40	766	766	NUM
admet-280	422	41	.	.	PUNCT
admet-280	423	1	[	[	X
admet-280	423	2	56	56	NUM
admet-280	423	3	]	]	PUNCT
admet-280	423	4	t.	t.	PROPN
admet-280	423	5	rau	rau	PROPN
admet-280	423	6	,	,	PUNCT
admet-280	423	7	s.	s.	PROPN
admet-280	423	8	diepenbruck	diepenbruck	PROPN
admet-280	423	9	,	,	PUNCT
admet-280	423	10	i.	i.	PROPN
admet-280	423	11	diepenbruck	diepenbruck	PROPN
admet-280	423	12	,	,	PUNCT
admet-280	423	13	t.	t.	NOUN
admet-280	423	14	eschenhagen	eschenhagen	PROPN
admet-280	423	15	,	,	PUNCT
admet-280	423	16	clin	clin	PROPN
admet-280	423	17	pharmacol	pharmacol	PROPN
admet-280	423	18	ther	ther	ADV
admet-280	423	19	80	80	NUM
admet-280	423	20	(	(	PUNCT
admet-280	423	21	2006	2006	NUM
admet-280	423	22	)	)	PUNCT
admet-280	423	23	555	555	NUM
admet-280	423	24	-	-	SYM
admet-280	423	25	558	558	NUM
admet-280	423	26	;	;	PUNCT
admet-280	423	27	author	author	NOUN
admet-280	423	28	reply	reply	VERB
admet-280	423	29	558	558	NUM
admet-280	423	30	-	-	SYM
admet-280	423	31	560	560	NUM
admet-280	423	32	.	.	PUNCT
admet-280	424	1	©	©	PROPN
admet-280	424	2	2016	2016	NUM
admet-280	424	3	by	by	ADP
admet-280	424	4	the	the	DET
admet-280	424	5	authors	author	NOUN
admet-280	424	6	;	;	PUNCT
admet-280	424	7	licensee	licensee	PROPN
admet-280	424	8	iapc	iapc	PROPN
admet-280	424	9	,	,	PUNCT
admet-280	424	10	zagreb	zagreb	PROPN
admet-280	424	11	,	,	PUNCT
admet-280	424	12	croatia	croatia	PROPN
admet-280	424	13	.	.	PUNCT
admet-280	425	1	this	this	DET
admet-280	425	2	article	article	NOUN
admet-280	425	3	is	be	AUX
admet-280	425	4	an	an	DET
admet-280	425	5	open	open	ADJ
admet-280	425	6	-	-	PUNCT
admet-280	425	7	access	access	NOUN
admet-280	425	8	article	article	NOUN
admet-280	425	9	distributed	distribute	VERB
admet-280	425	10	under	under	ADP
admet-280	425	11	the	the	DET
admet-280	425	12	terms	term	NOUN
admet-280	425	13	and	and	CCONJ
admet-280	425	14	conditions	condition	NOUN
admet-280	425	15	of	of	ADP
admet-280	425	16	the	the	DET
admet-280	425	17	creative	creative	ADJ
admet-280	425	18	commons	common	NOUN
admet-280	425	19	attribution	attribution	NOUN
admet-280	425	20	license	license	NOUN
admet-280	425	21	(	(	PUNCT
admet-280	425	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-280	425	23	)	)	PUNCT
admet-280	425	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-280	425	25	voellinger	voellinger	NOUN
admet-280	425	26	and	and	CCONJ
admet-280	425	27	kelly	kelly	PROPN
admet-280	425	28	admet	admet	PROPN
admet-280	425	29	&	&	CCONJ
admet-280	425	30	dmpk	dmpk	PROPN
admet-280	425	31	4(2	4(2	NUM
admet-280	425	32	)	)	PUNCT
admet-280	425	33	(	(	PUNCT
admet-280	425	34	2016	2016	NUM
admet-280	425	35	)	)	PUNCT
admet-280	425	36	62	62	NUM
admet-280	425	37	-	-	SYM
admet-280	425	38	83	83	NUM
admet-280	425	39	82	82	NUM
admet-280	425	40	supplemental	supplemental	ADJ
admet-280	425	41	material	material	NOUN
admet-280	425	42	admet	admet	PROPN
admet-280	425	43	&	&	CCONJ
admet-280	425	44	dmpk	dmpk	PROPN
admet-280	425	45	4(2	4(2	NUM
admet-280	425	46	)	)	PUNCT
admet-280	425	47	(	(	PUNCT
admet-280	425	48	2016	2016	NUM
admet-280	425	49	)	)	PUNCT
admet-280	425	50	62	62	NUM
admet-280	425	51	-	-	SYM
admet-280	425	52	83	83	NUM
admet-280	425	53	pharmacogenetics	pharmacogenetic	NOUN
admet-280	425	54	and	and	CCONJ
admet-280	425	55	cyp	cyp	ADJ
admet-280	425	56	activity	activity	NOUN
admet-280	425	57	doi	doi	NOUN
admet-280	425	58	:	:	PUNCT
admet-280	425	59	10.5599	10.5599	NUM
admet-280	425	60	/	/	SYM
admet-280	425	61	admet.4.2.280	admet.4.2.280	NUM
admet-280	425	62	83	83	NUM
admet-280	425	63	supplemental	supplemental	ADJ
admet-280	425	64	figure	figure	NOUN
admet-280	425	65	1	1	NUM
admet-280	425	66	.	.	PUNCT
admet-280	426	1	scdh	scdh	VERB
admet-280	426	2	gene	gene	NOUN
admet-280	426	3	expression	expression	NOUN
admet-280	426	4	characterization	characterization	NOUN
admet-280	426	5	.	.	PUNCT
admet-280	427	1	additional	additional	ADJ
admet-280	427	2	qrt	qrt	ADJ
admet-280	427	3	-	-	PUNCT
admet-280	427	4	pcr	pcr	ADJ
admet-280	427	5	results	result	NOUN
admet-280	427	6	shown	show	VERB
admet-280	427	7	as	as	ADP
admet-280	427	8	fold	fold	ADJ
admet-280	427	9	change	change	NOUN
admet-280	427	10	compared	compare	VERB
admet-280	427	11	to	to	ADP
admet-280	427	12	differentiated	differentiated	ADJ
admet-280	427	13	heparg	heparg	NOUN
admet-280	427	14	cells	cell	NOUN
admet-280	427	15	,	,	PUNCT
admet-280	427	16	which	which	PRON
admet-280	427	17	was	be	AUX
admet-280	427	18	set	set	VERB
admet-280	427	19	to	to	ADP
admet-280	427	20	1	1	NUM
admet-280	427	21	.	.	PUNCT
admet-280	428	1	gus	gus	NOUN
admet-280	428	2	-	-	PUNCT
admet-280	428	3	b	b	PROPN
admet-280	428	4	was	be	AUX
admet-280	428	5	used	use	VERB
admet-280	428	6	as	as	ADP
admet-280	428	7	a	a	DET
admet-280	428	8	housekeeping	housekeeping	NOUN
admet-280	428	9	gene	gene	NOUN
admet-280	428	10	.	.	PUNCT
admet-280	429	1	for	for	ADP
admet-280	429	2	all	all	DET
admet-280	429	3	stem	stem	NOUN
admet-280	429	4	cell	cell	NOUN
admet-280	429	5	and	and	CCONJ
admet-280	429	6	scdh	scdh	VERB
admet-280	429	7	samples	sample	NOUN
admet-280	429	8	,	,	PUNCT
admet-280	429	9	error	error	NOUN
admet-280	429	10	bars	bar	NOUN
admet-280	429	11	represent	represent	VERB
admet-280	429	12	a	a	DET
admet-280	429	13	pool	pool	NOUN
admet-280	429	14	of	of	ADP
admet-280	429	15	triplicate	triplicate	VERB
admet-280	429	16	biological	biological	ADJ
admet-280	429	17	replicates	replicate	NOUN
admet-280	429	18	and	and	CCONJ
admet-280	429	19	triplicate	triplicate	VERB
admet-280	429	20	technical	technical	ADJ
admet-280	429	21	replicates	replicate	NOUN
admet-280	429	22	.	.	PUNCT
admet-280	430	1	for	for	ADP
admet-280	430	2	all	all	DET
admet-280	430	3	other	other	ADJ
admet-280	430	4	samples	sample	NOUN
admet-280	430	5	,	,	PUNCT
admet-280	430	6	error	error	NOUN
admet-280	430	7	bars	bar	NOUN
admet-280	430	8	represent	represent	VERB
admet-280	430	9	triplicate	triplicate	VERB
admet-280	430	10	technical	technical	ADJ
admet-280	430	11	replicates	replicate	NOUN
admet-280	430	12	.	.	PUNCT
admet-280	431	1	heparg	heparg	PROPN
admet-280	431	2	undiff	undiff	PROPN
admet-280	431	3	represents	represent	VERB
admet-280	431	4	undifferentiated	undifferentiated	ADJ
admet-280	431	5	heparg	heparg	NOUN
admet-280	431	6	cells	cell	NOUN
admet-280	431	7	;	;	PUNCT
admet-280	431	8	heparg	heparg	NOUN
admet-280	431	9	diff	diff	NOUN
admet-280	431	10	represents	represent	VERB
admet-280	431	11	differentiated	differentiated	ADJ
admet-280	431	12	heparg	heparg	NOUN
admet-280	431	13	cells	cell	NOUN
admet-280	431	14	;	;	PUNCT
admet-280	431	15	fl1	fl1	ADV
admet-280	431	16	,	,	PUNCT
admet-280	431	17	fl2	fl2	PROPN
admet-280	431	18	,	,	PUNCT
admet-280	431	19	fl3	fl3	VERB
admet-280	431	20	,	,	PUNCT
admet-280	431	21	fl4	fl4	PROPN
admet-280	431	22	,	,	PUNCT
admet-280	431	23	fl5	fl5	PROPN
admet-280	431	24	,	,	PUNCT
admet-280	431	25	fl6	fl6	PROPN
admet-280	431	26	represent	represent	VERB
admet-280	431	27	fetal	fetal	ADJ
admet-280	431	28	liver	liver	NOUN
admet-280	431	29	tissue	tissue	NOUN
admet-280	431	30	1	1	NUM
admet-280	431	31	,	,	PUNCT
admet-280	431	32	2	2	NUM
admet-280	431	33	,	,	PUNCT
admet-280	431	34	3	3	NUM
admet-280	431	35	,	,	PUNCT
admet-280	431	36	4	4	NUM
admet-280	431	37	,	,	PUNCT
admet-280	431	38	5	5	NUM
admet-280	431	39	,	,	PUNCT
admet-280	431	40	6	6	NUM
admet-280	431	41	,	,	PUNCT
admet-280	431	42	respectively	respectively	ADV
admet-280	431	43	;	;	PUNCT
admet-280	431	44	hl161	hl161	ADJ
admet-280	431	45	and	and	CCONJ
admet-280	431	46	hl167	hl167	PROPN
admet-280	431	47	represent	represent	VERB
admet-280	431	48	human	human	ADJ
admet-280	431	49	liver	liver	NOUN
admet-280	431	50	bank	bank	NOUN
admet-280	431	51	samples	sample	NOUN
admet-280	431	52	161	161	NUM
admet-280	431	53	and	and	CCONJ
admet-280	431	54	167	167	NUM
admet-280	431	55	,	,	PUNCT
admet-280	431	56	respectively	respectively	ADV
admet-280	431	57	.	.	PUNCT