id	sid	tid	token	lemma	pos
admet-2802	1	1	bile	bile	NOUN
admet-2802	1	2	micelle	micelle	NOUN
admet-2802	1	3	binding	bind	VERB
admet-2802	1	4	of	of	ADP
admet-2802	1	5	structurally	structurally	ADV
admet-2802	1	6	diverse	diverse	ADJ
admet-2802	1	7	ionized	ionized	ADJ
admet-2802	1	8	drug	drug	NOUN
admet-2802	1	9	molecules	molecule	NOUN
admet-2802	1	10	doi	doi	NOUN
admet-2802	1	11	:	:	PUNCT
admet-2802	1	12	http://dx.doi.org/10.5599/admet.2802	http://dx.doi.org/10.5599/admet.2802	PROPN
admet-2802	1	13	1	1	NUM
admet-2802	1	14	admet	admet	X
admet-2802	1	15	&	&	CCONJ
admet-2802	1	16	dmpk	dmpk	PROPN
admet-2802	1	17	13(4	13(4	NUM
admet-2802	1	18	)	)	PUNCT
admet-2802	1	19	(	(	PUNCT
admet-2802	1	20	2025	2025	NUM
admet-2802	1	21	)	)	PUNCT
admet-2802	1	22	2802	2802	NUM
admet-2802	1	23	;	;	PUNCT
admet-2802	1	24	doi	doi	NOUN
admet-2802	1	25	:	:	PUNCT
admet-2802	1	26	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	1	27	open	open	ADJ
admet-2802	1	28	access	access	NOUN
admet-2802	1	29	:	:	PUNCT
admet-2802	1	30	issn	issn	PROPN
admet-2802	1	31	:	:	PUNCT
admet-2802	1	32	1848	1848	NUM
admet-2802	1	33	-	-	SYM
admet-2802	1	34	7718	7718	NUM
admet-2802	1	35	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	PROPN
admet-2802	1	36	original	original	ADJ
admet-2802	1	37	scientific	scientific	ADJ
admet-2802	1	38	paper	paper	NOUN
admet-2802	1	39	bile	bile	NOUN
admet-2802	1	40	micelle	micelle	NOUN
admet-2802	1	41	binding	bind	VERB
admet-2802	1	42	of	of	ADP
admet-2802	1	43	structurally	structurally	ADV
admet-2802	1	44	diverse	diverse	ADJ
admet-2802	1	45	ionized	ionized	ADJ
admet-2802	1	46	drug	drug	NOUN
admet-2802	1	47	molecules	molecule	NOUN
admet-2802	1	48	mayu	mayu	PROPN
admet-2802	1	49	konishi	konishi	PROPN
admet-2802	1	50	and	and	CCONJ
admet-2802	1	51	kiyohiko	kiyohiko	PROPN
admet-2802	1	52	sugano	sugano	PROPN
admet-2802	1	53	*	*	PUNCT
admet-2802	1	54	molecular	molecular	ADJ
admet-2802	1	55	pharmaceutics	pharmaceutic	NOUN
admet-2802	1	56	lab	lab	NOUN
admet-2802	1	57	.	.	PUNCT
admet-2802	1	58	,	,	PUNCT
admet-2802	1	59	college	college	NOUN
admet-2802	1	60	of	of	ADP
admet-2802	1	61	pharmaceutical	pharmaceutical	NOUN
admet-2802	1	62	sciences	science	NOUN
admet-2802	1	63	,	,	PUNCT
admet-2802	1	64	ritsumeikan	ritsumeikan	ADJ
admet-2802	1	65	university	university	NOUN
admet-2802	1	66	,	,	PUNCT
admet-2802	1	67	1	1	NUM
admet-2802	1	68	-	-	SYM
admet-2802	1	69	1	1	NUM
admet-2802	1	70	-	-	SYM
admet-2802	1	71	1	1	NUM
admet-2802	1	72	,	,	PUNCT
admet-2802	1	73	noji	noji	NOUN
admet-2802	1	74	-	-	PUNCT
admet-2802	1	75	higashi	higashi	PROPN
admet-2802	1	76	,	,	PUNCT
admet-2802	1	77	kusatsu	kusatsu	NOUN
admet-2802	1	78	,	,	PUNCT
admet-2802	1	79	shiga	shiga	NOUN
admet-2802	1	80	525	525	NUM
admet-2802	1	81	-	-	SYM
admet-2802	1	82	8577	8577	NUM
admet-2802	1	83	,	,	PUNCT
admet-2802	1	84	japan	japan	PROPN
admet-2802	1	85	*	*	PUNCT
admet-2802	1	86	corresponding	correspond	VERB
admet-2802	1	87	authors	author	NOUN
admet-2802	1	88	:	:	PUNCT
admet-2802	1	89	e	e	X
admet-2802	1	90	-	-	NOUN
admet-2802	1	91	mail	mail	NOUN
admet-2802	1	92	:	:	PUNCT
admet-2802	1	93	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-2802	1	94	;	;	PUNCT
admet-2802	1	95	tel	tel	PROPN
admet-2802	1	96	.	.	PROPN
admet-2802	1	97	:	:	PUNCT
admet-2802	2	1	+81	+81	PROPN
admet-2802	2	2	-	-	PUNCT
admet-2802	2	3	77	77	NUM
admet-2802	2	4	-	-	PUNCT
admet-2802	2	5	561	561	NUM
admet-2802	2	6	-	-	PUNCT
admet-2802	2	7	2773	2773	NUM
admet-2802	2	8	received	receive	VERB
admet-2802	2	9	:	:	PUNCT
admet-2802	2	10	may	may	AUX
admet-2802	2	11	15	15	NUM
admet-2802	2	12	,	,	PUNCT
admet-2802	2	13	2025	2025	NUM
admet-2802	2	14	;	;	PUNCT
admet-2802	2	15	revised	revise	VERB
admet-2802	2	16	:	:	PUNCT
admet-2802	2	17	july	july	PROPN
admet-2802	2	18	17	17	NUM
admet-2802	2	19	,	,	PUNCT
admet-2802	2	20	2025	2025	NUM
admet-2802	2	21	;	;	PUNCT
admet-2802	2	22	published	publish	VERB
admet-2802	2	23	:	:	PUNCT
admet-2802	2	24	july	july	PROPN
admet-2802	2	25	22	22	NUM
admet-2802	2	26	,	,	PUNCT
admet-2802	2	27	2025	2025	NUM
admet-2802	2	28	abstract	abstract	ADJ
admet-2802	2	29	background	background	NOUN
admet-2802	2	30	and	and	CCONJ
admet-2802	2	31	purpose	purpose	NOUN
admet-2802	2	32	:	:	PUNCT
admet-2802	2	33	predicting	predict	VERB
admet-2802	2	34	the	the	DET
admet-2802	2	35	food	food	NOUN
admet-2802	2	36	effect	effect	NOUN
admet-2802	2	37	on	on	ADP
admet-2802	2	38	oral	oral	ADJ
admet-2802	2	39	drug	drug	NOUN
admet-2802	2	40	absorption	absorption	NOUN
admet-2802	2	41	by	by	ADP
admet-2802	2	42	physiologically	physiologically	ADV
admet-2802	2	43	based	base	VERB
admet-2802	2	44	biopharmaceutical	biopharmaceutical	NOUN
admet-2802	2	45	modelling	modelling	NOUN
admet-2802	2	46	(	(	PUNCT
admet-2802	2	47	pbbm	pbbm	NOUN
admet-2802	2	48	)	)	PUNCT
admet-2802	2	49	remains	remain	VERB
admet-2802	2	50	challenging	challenge	VERB
admet-2802	2	51	.	.	PUNCT
admet-2802	3	1	the	the	DET
admet-2802	3	2	bile	bile	NOUN
admet-2802	3	3	micelle	micelle	NOUN
admet-2802	3	4	unbound	unbound	NOUN
admet-2802	3	5	fraction	fraction	NOUN
admet-2802	3	6	(	(	PUNCT
admet-2802	3	7	fu	fu	NOUN
admet-2802	3	8	)	)	PUNCT
admet-2802	3	9	is	be	AUX
admet-2802	3	10	one	one	NUM
admet-2802	3	11	of	of	ADP
admet-2802	3	12	the	the	DET
admet-2802	3	13	primary	primary	ADJ
admet-2802	3	14	determinants	determinant	NOUN
admet-2802	3	15	of	of	ADP
admet-2802	3	16	the	the	DET
admet-2802	3	17	negative	negative	ADJ
admet-2802	3	18	food	food	NOUN
admet-2802	3	19	effect	effect	NOUN
admet-2802	3	20	for	for	ADP
admet-2802	3	21	high	high	ADJ
admet-2802	3	22	solubility	solubility	NOUN
admet-2802	3	23	drugs	drug	NOUN
admet-2802	3	24	.	.	PUNCT
admet-2802	4	1	to	to	PART
admet-2802	4	2	calculate	calculate	VERB
admet-2802	4	3	the	the	DET
admet-2802	4	4	ph	ph	VERB
admet-2802	4	5	-	-	PUNCT
admet-2802	4	6	fu	fu	NOUN
admet-2802	4	7	profile	profile	NOUN
admet-2802	4	8	for	for	ADP
admet-2802	4	9	pbbm	pbbm	NOUN
admet-2802	4	10	,	,	PUNCT
admet-2802	4	11	the	the	DET
admet-2802	4	12	bile	bile	NOUN
admet-2802	4	13	micelle	micelle	NOUN
admet-2802	4	14	partition	partition	NOUN
admet-2802	4	15	coefficients	coefficient	NOUN
admet-2802	4	16	of	of	ADP
admet-2802	4	17	ionized	ionized	ADJ
admet-2802	4	18	and	and	CCONJ
admet-2802	4	19	un	un	ADJ
admet-2802	4	20	-	-	ADJ
admet-2802	4	21	ionized	ionize	VERB
admet-2802	4	22	drug	drug	NOUN
admet-2802	4	23	species	specie	NOUN
admet-2802	4	24	(	(	PUNCT
admet-2802	4	25	kbm	kbm	PROPN
admet-2802	4	26	,	,	PUNCT
admet-2802	4	27	z	z	PROPN
admet-2802	4	28	,	,	PUNCT
admet-2802	4	29	z	z	NOUN
admet-2802	4	30	:	:	PUNCT
admet-2802	4	31	charge	charge	NOUN
admet-2802	4	32	)	)	PUNCT
admet-2802	4	33	are	be	AUX
admet-2802	4	34	required	require	VERB
admet-2802	4	35	.	.	PUNCT
admet-2802	5	1	the	the	DET
admet-2802	5	2	general	general	ADJ
admet-2802	5	3	rules	rule	VERB
admet-2802	5	4	for	for	ADP
admet-2802	5	5	the	the	DET
admet-2802	5	6	ratio	ratio	NOUN
admet-2802	5	7	of	of	ADP
admet-2802	5	8	the	the	DET
admet-2802	5	9	partition	partition	NOUN
admet-2802	5	10	coefficients	coefficient	NOUN
admet-2802	5	11	of	of	ADP
admet-2802	5	12	ionized	ionized	ADJ
admet-2802	5	13	and	and	CCONJ
admet-2802	5	14	un	un	ADJ
admet-2802	5	15	-	-	ADJ
admet-2802	5	16	ionized	ionized	ADJ
admet-2802	5	17	drug	drug	NOUN
admet-2802	5	18	species	specie	NOUN
admet-2802	5	19	have	have	AUX
admet-2802	5	20	been	be	AUX
admet-2802	5	21	reported	report	VERB
admet-2802	5	22	for	for	ADP
admet-2802	5	23	the	the	DET
admet-2802	5	24	octanol	octanol	NOUN
admet-2802	5	25	/	/	SYM
admet-2802	5	26	water	water	NOUN
admet-2802	5	27	(	(	PUNCT
admet-2802	5	28	poct	poct	NOUN
admet-2802	5	29	)	)	PUNCT
admet-2802	5	30	and	and	CCONJ
admet-2802	5	31	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2802	5	32	liposome	liposome	NOUN
admet-2802	5	33	/	/	SYM
admet-2802	5	34	water	water	NOUN
admet-2802	5	35	partition	partition	NOUN
admet-2802	5	36	coefficients	coefficient	NOUN
admet-2802	5	37	.	.	PUNCT
admet-2802	6	1	however	however	ADV
admet-2802	6	2	,	,	PUNCT
admet-2802	6	3	the	the	DET
admet-2802	6	4	general	general	ADJ
admet-2802	6	5	rule	rule	NOUN
admet-2802	6	6	for	for	ADP
admet-2802	6	7	the	the	DET
admet-2802	6	8	bile	bile	NOUN
admet-2802	6	9	micelle	micelle	NOUN
admet-2802	6	10	partition	partition	NOUN
admet-2802	6	11	coefficient	coefficient	NOUN
admet-2802	6	12	has	have	AUX
admet-2802	6	13	not	not	PART
admet-2802	6	14	yet	yet	ADV
admet-2802	6	15	been	be	AUX
admet-2802	6	16	investigated	investigate	VERB
admet-2802	6	17	.	.	PUNCT
admet-2802	7	1	the	the	DET
admet-2802	7	2	purpose	purpose	NOUN
admet-2802	7	3	of	of	ADP
admet-2802	7	4	the	the	DET
admet-2802	7	5	present	present	ADJ
admet-2802	7	6	study	study	NOUN
admet-2802	7	7	was	be	AUX
admet-2802	7	8	to	to	PART
admet-2802	7	9	clarify	clarify	VERB
admet-2802	7	10	the	the	DET
admet-2802	7	11	general	general	ADJ
admet-2802	7	12	rule	rule	NOUN
admet-2802	7	13	for	for	ADP
admet-2802	7	14	kbm	kbm	PROPN
admet-2802	7	15	,	,	PUNCT
admet-2802	7	16	z≠0	z≠0	PROPN
admet-2802	7	17	/	/	SYM
admet-2802	7	18	kbm,0	kbm,0	PROPN
admet-2802	7	19	.	.	PUNCT
admet-2802	8	1	experimental	experimental	ADJ
admet-2802	8	2	approach	approach	NOUN
admet-2802	8	3	:	:	PUNCT
admet-2802	8	4	the	the	DET
admet-2802	8	5	ph	ph	VERB
admet-2802	8	6	-	-	PUNCT
admet-2802	8	7	fu	fu	ADJ
admet-2802	8	8	profiles	profile	NOUN
admet-2802	8	9	of	of	ADP
admet-2802	8	10	4	4	NUM
admet-2802	8	11	monovalent	monovalent	NOUN
admet-2802	8	12	weak	weak	ADJ
admet-2802	8	13	acids	acid	NOUN
admet-2802	8	14	,	,	PUNCT
admet-2802	8	15	8	8	NUM
admet-2802	8	16	monovalent	monovalent	NOUN
admet-2802	8	17	weak	weak	ADJ
admet-2802	8	18	bases	basis	NOUN
admet-2802	8	19	,	,	PUNCT
admet-2802	8	20	2	2	NUM
admet-2802	8	21	divalent	divalent	NOUN
admet-2802	8	22	weak	weak	ADJ
admet-2802	8	23	bases	basis	NOUN
admet-2802	8	24	,	,	PUNCT
admet-2802	8	25	and	and	CCONJ
admet-2802	8	26	2	2	NUM
admet-2802	8	27	zwitterion	zwitterion	NOUN
admet-2802	8	28	drugs	drug	NOUN
admet-2802	8	29	were	be	AUX
admet-2802	8	30	measured	measure	VERB
admet-2802	8	31	by	by	ADP
admet-2802	8	32	dynamic	dynamic	ADJ
admet-2802	8	33	dialysis	dialysis	NOUN
admet-2802	8	34	in	in	ADP
admet-2802	8	35	the	the	DET
admet-2802	8	36	ph	ph	ADJ
admet-2802	8	37	range	range	NOUN
admet-2802	8	38	about	about	ADP
admet-2802	8	39	pka	pka	PROPN
admet-2802	8	40	±	±	NUM
admet-2802	8	41	2	2	NUM
admet-2802	8	42	.	.	PUNCT
admet-2802	9	1	bile	bile	NOUN
admet-2802	9	2	micelles	micelle	NOUN
admet-2802	9	3	consisted	consist	VERB
admet-2802	9	4	of	of	ADP
admet-2802	9	5	taurocholic	taurocholic	ADJ
admet-2802	9	6	acid	acid	NOUN
admet-2802	9	7	(	(	PUNCT
admet-2802	9	8	tc)/egg	tc)/egg	PROPN
admet-2802	9	9	lecithin	lecithin	NOUN
admet-2802	9	10	(	(	PUNCT
admet-2802	9	11	15	15	NUM
admet-2802	9	12	mm/	mm/	PROPN
admet-2802	9	13	3.75	3.75	NUM
admet-2802	9	14	mm	mm	NOUN
admet-2802	9	15	)	)	PUNCT
admet-2802	9	16	.	.	PUNCT
admet-2802	10	1	kbm	kbm	PROPN
admet-2802	10	2	,	,	PUNCT
admet-2802	10	3	z	z	PROPN
admet-2802	10	4	was	be	AUX
admet-2802	10	5	calculated	calculate	VERB
admet-2802	10	6	from	from	ADP
admet-2802	10	7	the	the	DET
admet-2802	10	8	ph	ph	VERB
admet-2802	10	9	-	-	PUNCT
admet-2802	10	10	fu	fu	NOUN
admet-2802	10	11	profiles	profile	NOUN
admet-2802	10	12	.	.	PUNCT
admet-2802	11	1	key	key	ADJ
admet-2802	11	2	results	result	NOUN
admet-2802	11	3	:	:	PUNCT
admet-2802	11	4	kbm,-1	kbm,-1	PROPN
admet-2802	11	5	/	/	SYM
admet-2802	11	6	kbm,0	kbm,0	PROPN
admet-2802	11	7	was	be	AUX
admet-2802	11	8	≤	≤	NUM
admet-2802	11	9	0.03	0.03	NUM
admet-2802	11	10	for	for	ADP
admet-2802	11	11	all	all	DET
admet-2802	11	12	monovalent	monovalent	NOUN
admet-2802	11	13	acids	acid	NOUN
admet-2802	11	14	.	.	PUNCT
admet-2802	12	1	kbm,+1	kbm,+1	NOUN
admet-2802	12	2	/	/	SYM
admet-2802	12	3	kbm,0	kbm,0	PROPN
admet-2802	12	4	ranged	range	VERB
admet-2802	12	5	from	from	ADP
admet-2802	12	6	0.24	0.24	NUM
admet-2802	12	7	to	to	ADP
admet-2802	12	8	2.6	2.6	NUM
admet-2802	12	9	.	.	PUNCT
admet-2802	13	1	kbm,+2	kbm,+2	NOUN
admet-2802	13	2	/	/	SYM
admet-2802	13	3	kbm,0	kbm,0	PROPN
admet-2802	13	4	was	be	AUX
admet-2802	13	5	about	about	ADV
admet-2802	13	6	0.3	0.3	NUM
admet-2802	13	7	.	.	PUNCT
admet-2802	14	1	for	for	ADP
admet-2802	14	2	the	the	DET
admet-2802	14	3	two	two	NUM
admet-2802	14	4	zwitterionic	zwitterionic	ADJ
admet-2802	14	5	drugs	drug	NOUN
admet-2802	14	6	,	,	PUNCT
admet-2802	14	7	kbm,-1	kbm,-1	PROPN
admet-2802	14	8	/	/	SYM
admet-2802	14	9	kbm,±0	kbm,±0	NOUN
admet-2802	14	10	was	be	AUX
admet-2802	14	11	1.1	1.1	NUM
admet-2802	14	12	and	and	CCONJ
admet-2802	14	13	2.3	2.3	NUM
admet-2802	14	14	,	,	PUNCT
admet-2802	14	15	and	and	CCONJ
admet-2802	14	16	kbm,+1	kbm,+1	NOUN
admet-2802	14	17	/	/	SYM
admet-2802	14	18	kbm,±0	kbm,±0	NOUN
admet-2802	14	19	was	be	AUX
admet-2802	14	20	3.9	3.9	NUM
admet-2802	14	21	and	and	CCONJ
admet-2802	14	22	20	20	NUM
admet-2802	14	23	,	,	PUNCT
admet-2802	14	24	respectively	respectively	ADV
admet-2802	14	25	.	.	PUNCT
admet-2802	15	1	kbm,0	kbm,0	PROPN
admet-2802	15	2	roughly	roughly	ADV
admet-2802	15	3	correlated	correlate	VERB
admet-2802	15	4	with	with	ADP
admet-2802	15	5	poct	poct	NOUN
admet-2802	15	6	(	(	PUNCT
admet-2802	15	7	r	r	NOUN
admet-2802	15	8	=	=	NOUN
admet-2802	15	9	0.68	0.68	NUM
admet-2802	15	10	)	)	PUNCT
admet-2802	15	11	.	.	PUNCT
admet-2802	16	1	conclusion	conclusion	NOUN
admet-2802	16	2	:	:	PUNCT
admet-2802	16	3	the	the	DET
admet-2802	16	4	bile	bile	NOUN
admet-2802	16	5	micelle	micelle	NOUN
admet-2802	16	6	binding	bind	VERB
admet-2802	16	7	of	of	ADP
admet-2802	16	8	anionic	anionic	ADJ
admet-2802	16	9	drug	drug	NOUN
admet-2802	16	10	species	specie	NOUN
admet-2802	16	11	(	(	PUNCT
admet-2802	16	12	z	z	NOUN
admet-2802	16	13	=	=	SYM
admet-2802	16	14	-1	-1	PRON
admet-2802	16	15	)	)	PUNCT
admet-2802	16	16	is	be	AUX
admet-2802	16	17	generally	generally	ADV
admet-2802	16	18	negligible	negligible	ADJ
admet-2802	16	19	,	,	PUNCT
admet-2802	16	20	whereas	whereas	SCONJ
admet-2802	16	21	that	that	PRON
admet-2802	16	22	of	of	ADP
admet-2802	16	23	cationic	cationic	ADJ
admet-2802	16	24	drug	drug	NOUN
admet-2802	16	25	species	specie	NOUN
admet-2802	16	26	(	(	PUNCT
admet-2802	16	27	z	z	NOUN
admet-2802	16	28	=	=	SYM
admet-2802	16	29	+1	+1	PROPN
admet-2802	16	30	)	)	PUNCT
admet-2802	16	31	can	can	AUX
admet-2802	16	32	be	be	AUX
admet-2802	16	33	significant	significant	ADJ
admet-2802	16	34	.	.	PUNCT
admet-2802	17	1	a	a	DET
admet-2802	17	2	general	general	ADJ
admet-2802	17	3	rule	rule	NOUN
admet-2802	17	4	for	for	ADP
admet-2802	17	5	kbm,+1	kbm,+1	PROPN
admet-2802	17	6	/	/	SYM
admet-2802	17	7	kbm,0	kbm,0	PROPN
admet-2802	17	8	was	be	AUX
admet-2802	17	9	not	not	PART
admet-2802	17	10	found	find	VERB
admet-2802	17	11	.	.	PUNCT
admet-2802	18	1	kbm,+1	kbm,+1	PROPN
admet-2802	18	2	/	/	SYM
admet-2802	18	3	kbm,0	kbm,0	PROPN
admet-2802	18	4	can	can	AUX
admet-2802	18	5	be	be	AUX
admet-2802	18	6	greater	great	ADJ
admet-2802	18	7	than	than	ADP
admet-2802	18	8	1	1	NUM
admet-2802	18	9	in	in	ADP
admet-2802	18	10	several	several	ADJ
admet-2802	18	11	cases	case	NOUN
admet-2802	18	12	,	,	PUNCT
admet-2802	18	13	suggesting	suggest	VERB
admet-2802	18	14	an	an	DET
admet-2802	18	15	attractive	attractive	ADJ
admet-2802	18	16	electrostatic	electrostatic	ADJ
admet-2802	18	17	interaction	interaction	NOUN
admet-2802	18	18	between	between	ADP
admet-2802	18	19	the	the	DET
admet-2802	18	20	positive	positive	ADJ
admet-2802	18	21	charge	charge	NOUN
admet-2802	18	22	of	of	ADP
admet-2802	18	23	a	a	DET
admet-2802	18	24	drug	drug	NOUN
admet-2802	18	25	and	and	CCONJ
admet-2802	18	26	the	the	DET
admet-2802	18	27	negative	negative	ADJ
admet-2802	18	28	charge	charge	NOUN
admet-2802	18	29	of	of	ADP
admet-2802	18	30	tc	tc	NOUN
admet-2802	18	31	.	.	PUNCT
admet-2802	19	1	these	these	DET
admet-2802	19	2	points	point	NOUN
admet-2802	19	3	should	should	AUX
admet-2802	19	4	be	be	AUX
admet-2802	19	5	considered	consider	VERB
admet-2802	19	6	in	in	ADP
admet-2802	19	7	food	food	NOUN
admet-2802	19	8	effect	effect	NOUN
admet-2802	19	9	prediction	prediction	NOUN
admet-2802	19	10	.	.	PUNCT
admet-2802	20	1	©	©	PROPN
admet-2802	20	2	2025	2025	NUM
admet-2802	20	3	by	by	ADP
admet-2802	20	4	the	the	DET
admet-2802	20	5	authors	author	NOUN
admet-2802	20	6	.	.	PUNCT
admet-2802	21	1	this	this	DET
admet-2802	21	2	article	article	NOUN
admet-2802	21	3	is	be	AUX
admet-2802	21	4	an	an	DET
admet-2802	21	5	open	open	ADJ
admet-2802	21	6	-	-	PUNCT
admet-2802	21	7	access	access	NOUN
admet-2802	21	8	article	article	NOUN
admet-2802	21	9	distributed	distribute	VERB
admet-2802	21	10	under	under	ADP
admet-2802	21	11	the	the	DET
admet-2802	21	12	terms	term	NOUN
admet-2802	21	13	and	and	CCONJ
admet-2802	21	14	conditions	condition	NOUN
admet-2802	21	15	of	of	ADP
admet-2802	21	16	the	the	DET
admet-2802	21	17	creative	creative	ADJ
admet-2802	21	18	commons	common	NOUN
admet-2802	21	19	attribution	attribution	NOUN
admet-2802	21	20	license	license	NOUN
admet-2802	21	21	(	(	PUNCT
admet-2802	21	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2802	21	23	)	)	PUNCT
admet-2802	21	24	.	.	PUNCT
admet-2802	22	1	keywords	keyword	VERB
admet-2802	22	2	bile	bile	NOUN
admet-2802	22	3	micelles	micelle	NOUN
admet-2802	22	4	;	;	PUNCT
admet-2802	22	5	ionizable	ionizable	ADJ
admet-2802	22	6	drug	drug	NOUN
admet-2802	22	7	;	;	PUNCT
admet-2802	22	8	unbound	unbound	NOUN
admet-2802	22	9	fraction	fraction	NOUN
admet-2802	22	10	;	;	PUNCT
admet-2802	22	11	dynamic	dynamic	ADJ
admet-2802	22	12	dialysis	dialysis	NOUN
admet-2802	22	13	;	;	PUNCT
admet-2802	22	14	intestinal	intestinal	ADJ
admet-2802	22	15	membrane	membrane	NOUN
admet-2802	22	16	permeation	permeation	NOUN
admet-2802	22	17	;	;	PUNCT
admet-2802	22	18	physiologically	physiologically	ADV
admet-2802	22	19	-	-	PUNCT
admet-2802	22	20	based	base	VERB
admet-2802	22	21	biopharmaceutics	biopharmaceutics	NOUN
admet-2802	22	22	modelling	model	VERB
admet-2802	22	23	introduction	introduction	NOUN
admet-2802	22	24	oral	oral	ADJ
admet-2802	22	25	drug	drug	NOUN
admet-2802	22	26	absorption	absorption	NOUN
admet-2802	22	27	is	be	AUX
admet-2802	22	28	affected	affect	VERB
admet-2802	22	29	by	by	ADP
admet-2802	22	30	various	various	ADJ
admet-2802	22	31	gastrointestinal	gastrointestinal	ADJ
admet-2802	22	32	(	(	PUNCT
admet-2802	22	33	gi	gi	NOUN
admet-2802	22	34	)	)	PUNCT
admet-2802	22	35	conditions	condition	NOUN
admet-2802	23	1	[	[	X
admet-2802	23	2	1	1	NUM
admet-2802	23	3	]	]	PUNCT
admet-2802	23	4	.	.	PUNCT
admet-2802	24	1	physiologically	physiologically	ADV
admet-2802	24	2	based	base	VERB
admet-2802	24	3	biopharmaceutics	biopharmaceutics	NOUN
admet-2802	24	4	modelling	modelling	NOUN
admet-2802	24	5	(	(	PUNCT
admet-2802	24	6	pbbm	pbbm	NUM
admet-2802	24	7	)	)	PUNCT
admet-2802	24	8	is	be	AUX
admet-2802	24	9	anticipated	anticipate	VERB
admet-2802	24	10	to	to	PART
admet-2802	24	11	be	be	AUX
admet-2802	24	12	a	a	DET
admet-2802	24	13	powerful	powerful	ADJ
admet-2802	24	14	tool	tool	NOUN
admet-2802	24	15	to	to	PART
admet-2802	24	16	predict	predict	VERB
admet-2802	24	17	the	the	DET
admet-2802	24	18	effect	effect	NOUN
admet-2802	24	19	of	of	ADP
admet-2802	24	20	gi	gi	NOUN
admet-2802	24	21	conditions	condition	NOUN
admet-2802	24	22	on	on	ADP
admet-2802	24	23	oral	oral	ADJ
admet-2802	24	24	drug	drug	NOUN
admet-2802	24	25	absorption	absorption	NOUN
admet-2802	24	26	.	.	PUNCT
admet-2802	25	1	the	the	DET
admet-2802	25	2	gi	gi	NOUN
admet-2802	25	3	conditions	condition	NOUN
admet-2802	25	4	in	in	ADP
admet-2802	25	5	the	the	DET
admet-2802	25	6	fed	fed	PROPN
admet-2802	25	7	state	state	NOUN
admet-2802	25	8	differ	differ	VERB
admet-2802	25	9	from	from	ADP
admet-2802	25	10	those	those	PRON
admet-2802	25	11	in	in	ADP
admet-2802	25	12	the	the	DET
admet-2802	25	13	fasted	fasted	ADJ
admet-2802	25	14	state	state	NOUN
admet-2802	25	15	.	.	PUNCT
admet-2802	26	1	for	for	ADP
admet-2802	26	2	example	example	NOUN
admet-2802	26	3	,	,	PUNCT
admet-2802	26	4	the	the	DET
admet-2802	26	5	concentration	concentration	NOUN
admet-2802	26	6	of	of	ADP
admet-2802	26	7	bile	bile	NOUN
admet-2802	26	8	micelles	micelle	NOUN
admet-2802	26	9	(	(	PUNCT
admet-2802	26	10	cbm	cbm	NOUN
admet-2802	26	11	)	)	PUNCT
admet-2802	26	12	increases	increase	VERB
admet-2802	26	13	about	about	ADV
admet-2802	26	14	5	5	NOUN
admet-2802	26	15	-	-	NOUN
admet-2802	26	16	fold	fold	ADJ
admet-2802	26	17	in	in	ADP
admet-2802	26	18	the	the	DET
admet-2802	26	19	fed	fed	PROPN
admet-2802	26	20	state	state	NOUN
admet-2802	26	21	compared	compare	VERB
admet-2802	26	22	to	to	ADP
admet-2802	26	23	the	the	DET
admet-2802	26	24	fasted	fasted	ADJ
admet-2802	26	25	state	state	NOUN
admet-2802	26	26	[	[	X
admet-2802	26	27	2,3	2,3	NUM
admet-2802	26	28	]	]	PUNCT
admet-2802	26	29	.	.	PUNCT
admet-2802	27	1	it	it	PRON
admet-2802	27	2	has	have	AUX
admet-2802	27	3	previously	previously	ADV
admet-2802	27	4	been	be	AUX
admet-2802	27	5	suggested	suggest	VERB
admet-2802	27	6	that	that	SCONJ
admet-2802	27	7	the	the	DET
admet-2802	27	8	unbound	unbound	NOUN
admet-2802	27	9	(	(	PUNCT
admet-2802	27	10	free	free	ADJ
admet-2802	27	11	)	)	PUNCT
admet-2802	27	12	fraction	fraction	NOUN
admet-2802	27	13	(	(	PUNCT
admet-2802	27	14	fu	fu	NOUN
admet-2802	27	15	)	)	PUNCT
admet-2802	27	16	of	of	ADP
admet-2802	27	17	a	a	DET
admet-2802	27	18	drug	drug	NOUN
admet-2802	27	19	in	in	ADP
admet-2802	27	20	the	the	DET
admet-2802	27	21	intestinal	intestinal	ADJ
admet-2802	27	22	fluid	fluid	NOUN
admet-2802	27	23	is	be	AUX
admet-2802	27	24	one	one	NUM
admet-2802	27	25	of	of	ADP
admet-2802	27	26	the	the	DET
admet-2802	27	27	factors	factor	NOUN
admet-2802	27	28	of	of	ADP
admet-2802	27	29	the	the	DET
admet-2802	27	30	negative	negative	ADJ
admet-2802	27	31	food	food	NOUN
admet-2802	27	32	effect	effect	NOUN
admet-2802	27	33	on	on	ADP
admet-2802	27	34	the	the	DET
admet-2802	27	35	oral	oral	ADJ
admet-2802	27	36	absorption	absorption	NOUN
admet-2802	27	37	of	of	ADP
admet-2802	27	38	highly	highly	ADV
admet-2802	27	39	soluble	soluble	ADJ
admet-2802	27	40	weak	weak	ADJ
admet-2802	27	41	base	base	NOUN
admet-2802	27	42	drugs	drug	NOUN
admet-2802	27	43	[	[	X
admet-2802	27	44	4,5	4,5	NUM
admet-2802	27	45	]	]	PUNCT
admet-2802	27	46	.	.	PUNCT
admet-2802	28	1	an	an	DET
admet-2802	28	2	increase	increase	NOUN
admet-2802	28	3	in	in	ADP
admet-2802	28	4	bile	bile	NOUN
admet-2802	28	5	micelle	micelle	NOUN
admet-2802	28	6	binding	bind	VERB
admet-2802	28	7	in	in	ADP
admet-2802	28	8	the	the	DET
admet-2802	28	9	fed	fed	PROPN
admet-2802	28	10	state	state	NOUN
admet-2802	28	11	reduces	reduce	VERB
admet-2802	28	12	fu	fu	NOUN
admet-2802	28	13	,	,	PUNCT
admet-2802	28	14	resulting	result	VERB
admet-2802	28	15	in	in	ADP
admet-2802	28	16	a	a	DET
admet-2802	28	17	decrease	decrease	NOUN
admet-2802	28	18	in	in	ADP
admet-2802	28	19	the	the	DET
admet-2802	28	20	effective	effective	ADJ
admet-2802	28	21	intestinal	intestinal	ADJ
admet-2802	28	22	http://dx.doi.org/10.5599/admet.2802	http://dx.doi.org/10.5599/admet.2802	X
admet-2802	28	23	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	28	24	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2802	28	25	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	NOUN
admet-2802	28	26	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2802	28	27	m.	m.	NOUN
admet-2802	28	28	konishi	konishi	PROPN
admet-2802	28	29	and	and	CCONJ
admet-2802	28	30	k.	k.	PROPN
admet-2802	28	31	sugano	sugano	PROPN
admet-2802	28	32	admet	admet	PROPN
admet-2802	28	33	&	&	CCONJ
admet-2802	28	34	dmpk	dmpk	PROPN
admet-2802	28	35	13(4	13(4	NUM
admet-2802	28	36	)	)	PUNCT
admet-2802	28	37	(	(	PUNCT
admet-2802	28	38	2025	2025	NUM
admet-2802	28	39	)	)	PUNCT
admet-2802	28	40	2802	2802	NUM
admet-2802	28	41	2	2	NUM
admet-2802	28	42	permeability	permeability	NOUN
admet-2802	28	43	(	(	PUNCT
admet-2802	28	44	peff	peff	PROPN
admet-2802	28	45	)	)	PUNCT
admet-2802	28	46	and	and	CCONJ
admet-2802	28	47	a	a	DET
admet-2802	28	48	negative	negative	ADJ
admet-2802	28	49	food	food	NOUN
admet-2802	28	50	effect	effect	NOUN
admet-2802	28	51	on	on	ADP
admet-2802	28	52	oral	oral	ADJ
admet-2802	28	53	drug	drug	NOUN
admet-2802	28	54	absorption	absorption	NOUN
admet-2802	28	55	(	(	PUNCT
admet-2802	28	56	cf	cf	NOUN
admet-2802	28	57	.	.	PUNCT
admet-2802	29	1	peff	peff	PROPN
admet-2802	29	2	is	be	AUX
admet-2802	29	3	defined	define	VERB
admet-2802	29	4	based	base	VERB
admet-2802	29	5	on	on	ADP
admet-2802	29	6	the	the	DET
admet-2802	29	7	total	total	ADJ
admet-2802	29	8	dissolved	dissolve	VERB
admet-2802	29	9	drug	drug	NOUN
admet-2802	29	10	concentration	concentration	NOUN
admet-2802	29	11	(=	(=	ADV
admet-2802	29	12	bound	bind	VERB
admet-2802	29	13	+	+	NUM
admet-2802	29	14	unbound	unbound	NOUN
admet-2802	29	15	concentrations	concentration	NOUN
admet-2802	29	16	)	)	PUNCT
admet-2802	29	17	)	)	PUNCT
admet-2802	30	1	[	[	X
admet-2802	30	2	6	6	NUM
admet-2802	30	3	-	-	SYM
admet-2802	30	4	10	10	NUM
admet-2802	30	5	]	]	PUNCT
admet-2802	30	6	.	.	PUNCT
admet-2802	31	1	bile	bile	NOUN
admet-2802	31	2	micelle	micelle	NOUN
admet-2802	31	3	-	-	PUNCT
admet-2802	31	4	bound	bind	VERB
admet-2802	31	5	drug	drug	NOUN
admet-2802	31	6	molecules	molecule	NOUN
admet-2802	31	7	diffuse	diffuse	VERB
admet-2802	31	8	across	across	ADP
admet-2802	31	9	the	the	DET
admet-2802	31	10	unstirred	unstirred	ADJ
admet-2802	31	11	water	water	NOUN
admet-2802	31	12	layer	layer	NOUN
admet-2802	31	13	(	(	PUNCT
admet-2802	31	14	uwl	uwl	NOUN
admet-2802	31	15	)	)	PUNCT
admet-2802	31	16	adjacent	adjacent	ADJ
admet-2802	31	17	to	to	ADP
admet-2802	31	18	the	the	DET
admet-2802	31	19	epithelial	epithelial	ADJ
admet-2802	31	20	membrane	membrane	NOUN
admet-2802	31	21	;	;	PUNCT
admet-2802	31	22	however	however	ADV
admet-2802	31	23	,	,	PUNCT
admet-2802	31	24	only	only	ADV
admet-2802	31	25	unbound	unbound	NOUN
admet-2802	31	26	drug	drug	NOUN
admet-2802	31	27	molecules	molecule	NOUN
admet-2802	31	28	permeate	permeate	VERB
admet-2802	31	29	the	the	DET
admet-2802	31	30	epithelial	epithelial	ADJ
admet-2802	31	31	membrane	membrane	NOUN
admet-2802	31	32	[	[	X
admet-2802	31	33	5	5	NUM
admet-2802	31	34	]	]	PUNCT
admet-2802	31	35	.	.	PUNCT
admet-2802	32	1	when	when	SCONJ
admet-2802	32	2	peff	peff	PROPN
admet-2802	32	3	is	be	AUX
admet-2802	32	4	rate	rate	NOUN
admet-2802	32	5	-	-	PUNCT
admet-2802	32	6	limited	limit	VERB
admet-2802	32	7	by	by	ADP
admet-2802	32	8	the	the	DET
admet-2802	32	9	epithelial	epithelial	ADJ
admet-2802	32	10	membrane	membrane	NOUN
admet-2802	32	11	permeation	permeation	NOUN
admet-2802	32	12	,	,	PUNCT
admet-2802	32	13	peff	peff	PROPN
admet-2802	32	14	∝	∝	PROPN
admet-2802	32	15	fupep	fupep	PROPN
admet-2802	32	16	(	(	PUNCT
admet-2802	32	17	pep	pep	NOUN
admet-2802	32	18	:	:	PUNCT
admet-2802	32	19	the	the	DET
admet-2802	32	20	epithelial	epithelial	ADJ
admet-2802	32	21	membrane	membrane	NOUN
admet-2802	32	22	permeability	permeability	NOUN
admet-2802	32	23	of	of	ADP
admet-2802	32	24	unbound	unbound	NOUN
admet-2802	32	25	drug	drug	NOUN
admet-2802	32	26	molecules	molecule	NOUN
admet-2802	32	27	[	[	X
admet-2802	32	28	5	5	NUM
admet-2802	32	29	]	]	NUM
admet-2802	32	30	)	)	PUNCT
admet-2802	32	31	.	.	PUNCT
admet-2802	33	1	the	the	DET
admet-2802	33	2	fu	fu	PROPN
admet-2802	33	3	value	value	NOUN
admet-2802	33	4	of	of	ADP
admet-2802	33	5	an	an	DET
admet-2802	33	6	ionizable	ionizable	ADJ
admet-2802	33	7	drug	drug	NOUN
admet-2802	33	8	depends	depend	VERB
admet-2802	33	9	on	on	ADP
admet-2802	33	10	the	the	DET
admet-2802	33	11	ph	ph	ADJ
admet-2802	33	12	value	value	NOUN
admet-2802	33	13	,	,	PUNCT
admet-2802	33	14	which	which	PRON
admet-2802	33	15	can	can	AUX
admet-2802	33	16	vary	vary	VERB
admet-2802	33	17	in	in	ADP
admet-2802	33	18	the	the	DET
admet-2802	33	19	small	small	ADJ
admet-2802	33	20	intestine	intestine	NOUN
admet-2802	33	21	due	due	ADP
admet-2802	33	22	to	to	ADP
admet-2802	33	23	factors	factor	NOUN
admet-2802	33	24	such	such	ADJ
admet-2802	33	25	as	as	ADP
admet-2802	33	26	the	the	DET
admet-2802	33	27	intestinal	intestinal	ADJ
admet-2802	33	28	position	position	NOUN
admet-2802	33	29	,	,	PUNCT
admet-2802	33	30	postprandial	postprandial	ADJ
admet-2802	33	31	conditions	condition	NOUN
admet-2802	33	32	,	,	PUNCT
admet-2802	33	33	and	and	CCONJ
admet-2802	33	34	intraand	intraand	CCONJ
admet-2802	33	35	inter	inter	ADJ
admet-2802	33	36	-	-	ADJ
admet-2802	33	37	individual	individual	ADJ
admet-2802	33	38	variations	variation	NOUN
admet-2802	33	39	.	.	PUNCT
admet-2802	34	1	therefore	therefore	ADV
admet-2802	34	2	,	,	PUNCT
admet-2802	34	3	a	a	DET
admet-2802	34	4	phfu	phfu	NOUN
admet-2802	34	5	profile	profile	NOUN
admet-2802	34	6	is	be	AUX
admet-2802	34	7	required	require	VERB
admet-2802	34	8	for	for	ADP
admet-2802	34	9	accurate	accurate	ADJ
admet-2802	34	10	food	food	NOUN
admet-2802	34	11	effect	effect	NOUN
admet-2802	34	12	prediction	prediction	NOUN
admet-2802	34	13	.	.	PUNCT
admet-2802	35	1	to	to	PART
admet-2802	35	2	calculate	calculate	VERB
admet-2802	35	3	the	the	DET
admet-2802	35	4	ph	ph	VERB
admet-2802	35	5	-	-	PUNCT
admet-2802	35	6	fu	fu	NOUN
admet-2802	35	7	profile	profile	NOUN
admet-2802	35	8	,	,	PUNCT
admet-2802	35	9	the	the	DET
admet-2802	35	10	bile	bile	NOUN
admet-2802	35	11	micelle	micelle	NOUN
admet-2802	35	12	partition	partition	NOUN
admet-2802	35	13	coefficient	coefficient	NOUN
admet-2802	35	14	(	(	PUNCT
admet-2802	35	15	kbm	kbm	PROPN
admet-2802	35	16	,	,	PUNCT
admet-2802	35	17	z	z	PROPN
admet-2802	35	18	,	,	PUNCT
admet-2802	35	19	z	z	NOUN
admet-2802	35	20	=	=	SYM
admet-2802	35	21	charge	charge	NOUN
admet-2802	35	22	)	)	PUNCT
admet-2802	35	23	of	of	ADP
admet-2802	35	24	both	both	CCONJ
admet-2802	35	25	un	un	ADJ
admet-2802	35	26	-	-	ADJ
admet-2802	35	27	ionized	ionized	ADJ
admet-2802	35	28	(	(	PUNCT
admet-2802	35	29	z	z	NOUN
admet-2802	35	30	=	=	NOUN
admet-2802	35	31	0	0	NUM
admet-2802	35	32	)	)	PUNCT
admet-2802	35	33	and	and	CCONJ
admet-2802	35	34	ionized	ionized	ADJ
admet-2802	35	35	drug	drug	NOUN
admet-2802	35	36	species	specie	NOUN
admet-2802	35	37	(	(	PUNCT
admet-2802	35	38	z	z	NOUN
admet-2802	35	39	≠	≠	PROPN
admet-2802	35	40	0	0	NUM
admet-2802	35	41	)	)	PUNCT
admet-2802	35	42	is	be	AUX
admet-2802	35	43	required	require	VERB
admet-2802	35	44	.	.	PUNCT
admet-2802	36	1	kbm	kbm	NOUN
admet-2802	36	2	is	be	AUX
admet-2802	36	3	the	the	DET
admet-2802	36	4	ratio	ratio	NOUN
admet-2802	36	5	of	of	ADP
admet-2802	36	6	drug	drug	NOUN
admet-2802	36	7	concentration	concentration	NOUN
admet-2802	36	8	in	in	ADP
admet-2802	36	9	the	the	DET
admet-2802	36	10	bile	bile	NOUN
admet-2802	36	11	micelles	micelle	NOUN
admet-2802	36	12	to	to	ADP
admet-2802	36	13	the	the	DET
admet-2802	36	14	water	water	NOUN
admet-2802	36	15	phase	phase	NOUN
admet-2802	36	16	,	,	PUNCT
admet-2802	36	17	normalized	normalize	VERB
admet-2802	36	18	by	by	ADP
admet-2802	36	19	the	the	DET
admet-2802	36	20	bile	bile	NOUN
admet-2802	36	21	micelle	micelle	NOUN
admet-2802	36	22	and	and	CCONJ
admet-2802	36	23	water	water	NOUN
admet-2802	36	24	concentrations	concentration	NOUN
admet-2802	36	25	[	[	X
admet-2802	36	26	11	11	NUM
admet-2802	36	27	]	]	PUNCT
admet-2802	36	28	.	.	PUNCT
admet-2802	37	1	in	in	ADP
admet-2802	37	2	the	the	DET
admet-2802	37	3	case	case	NOUN
admet-2802	37	4	of	of	ADP
admet-2802	37	5	the	the	DET
admet-2802	37	6	octanol	octanol	NOUN
admet-2802	37	7	-	-	PUNCT
admet-2802	37	8	water	water	NOUN
admet-2802	37	9	partition	partition	NOUN
admet-2802	37	10	coefficient	coefficient	NOUN
admet-2802	37	11	(	(	PUNCT
admet-2802	37	12	poct	poct	PROPN
admet-2802	37	13	)	)	PUNCT
admet-2802	37	14	,	,	PUNCT
admet-2802	37	15	the	the	DET
admet-2802	37	16	ratios	ratio	NOUN
admet-2802	37	17	of	of	ADP
admet-2802	37	18	the	the	DET
admet-2802	37	19	partition	partition	NOUN
admet-2802	37	20	coefficients	coefficient	NOUN
admet-2802	37	21	of	of	ADP
admet-2802	37	22	cationic	cationic	ADJ
admet-2802	37	23	species	specie	NOUN
admet-2802	37	24	(	(	PUNCT
admet-2802	37	25	poct,+1	poct,+1	NOUN
admet-2802	37	26	)	)	PUNCT
admet-2802	37	27	and	and	CCONJ
admet-2802	37	28	anionic	anionic	ADJ
admet-2802	37	29	species	specie	NOUN
admet-2802	37	30	(	(	PUNCT
admet-2802	37	31	poct,-1	poct,-1	NOUN
admet-2802	37	32	)	)	PUNCT
admet-2802	37	33	to	to	ADP
admet-2802	37	34	un	un	ADJ
admet-2802	37	35	-	-	ADJ
admet-2802	37	36	ionized	ionized	ADJ
admet-2802	37	37	species	specie	NOUN
admet-2802	37	38	(	(	PUNCT
admet-2802	37	39	poct,0	poct,0	NOUN
admet-2802	37	40	)	)	PUNCT
admet-2802	37	41	are	be	AUX
admet-2802	37	42	generally	generally	ADV
admet-2802	37	43	approximated	approximate	VERB
admet-2802	37	44	to	to	PART
admet-2802	37	45	be	be	AUX
admet-2802	37	46	about	about	ADP
admet-2802	37	47	poct,+1/	poct,+1/	NOUN
admet-2802	37	48	poct,0	poct,0	NOUN
admet-2802	37	49	≈	≈	PROPN
admet-2802	37	50	1/1000	1/1000	NUM
admet-2802	37	51	and	and	CCONJ
admet-2802	37	52	poct,-1/	poct,-1/	NOUN
admet-2802	37	53	poct,0	poct,0	NOUN
admet-2802	37	54	≈	≈	PROPN
admet-2802	37	55	1/10000	1/10000	NUM
admet-2802	37	56	,	,	PUNCT
admet-2802	37	57	respectively	respectively	ADV
admet-2802	37	58	(	(	PUNCT
admet-2802	37	59	in	in	ADP
admet-2802	37	60	the	the	DET
admet-2802	37	61	presence	presence	NOUN
admet-2802	37	62	of	of	ADP
admet-2802	37	63	0.15	0.15	NUM
admet-2802	37	64	m	m	NOUN
admet-2802	37	65	nacl	nacl	NOUN
admet-2802	37	66	)	)	PUNCT
admet-2802	38	1	[	[	X
admet-2802	38	2	12	12	NUM
admet-2802	38	3	]	]	PUNCT
admet-2802	38	4	.	.	PUNCT
admet-2802	39	1	in	in	ADP
admet-2802	39	2	the	the	DET
admet-2802	39	3	case	case	NOUN
admet-2802	39	4	of	of	ADP
admet-2802	39	5	the	the	DET
admet-2802	39	6	liposome	liposome	NOUN
admet-2802	39	7	-	-	PUNCT
admet-2802	39	8	water	water	NOUN
admet-2802	39	9	partition	partition	NOUN
admet-2802	39	10	coefficient	coefficient	NOUN
admet-2802	39	11	of	of	ADP
admet-2802	39	12	phosphatidylcholine	phosphatidylcholine	NOUN
admet-2802	39	13	(	(	PUNCT
admet-2802	39	14	pc	pc	NOUN
admet-2802	39	15	)	)	PUNCT
admet-2802	39	16	liposomes	liposome	NOUN
admet-2802	39	17	,	,	PUNCT
admet-2802	39	18	the	the	DET
admet-2802	39	19	ratios	ratio	NOUN
admet-2802	39	20	of	of	ADP
admet-2802	39	21	the	the	DET
admet-2802	39	22	partition	partition	NOUN
admet-2802	39	23	coefficients	coefficient	NOUN
admet-2802	39	24	of	of	ADP
admet-2802	39	25	cationic	cationic	ADJ
admet-2802	39	26	species	specie	NOUN
admet-2802	39	27	(	(	PUNCT
admet-2802	39	28	kpc,+1	kpc,+1	PROPN
admet-2802	39	29	)	)	PUNCT
admet-2802	39	30	and	and	CCONJ
admet-2802	39	31	anionic	anionic	ADJ
admet-2802	39	32	species	specie	NOUN
admet-2802	39	33	(	(	PUNCT
admet-2802	39	34	kpc,-1	kpc,-1	PROPN
admet-2802	39	35	)	)	PUNCT
admet-2802	39	36	to	to	ADP
admet-2802	39	37	un	un	ADJ
admet-2802	39	38	-	-	ADJ
admet-2802	39	39	ionized	ionized	ADJ
admet-2802	39	40	species	specie	NOUN
admet-2802	39	41	(	(	PUNCT
admet-2802	39	42	kpc,0	kpc,0	NOUN
admet-2802	39	43	)	)	PUNCT
admet-2802	39	44	are	be	AUX
admet-2802	39	45	generally	generally	ADV
admet-2802	39	46	approximated	approximate	VERB
admet-2802	39	47	to	to	PART
admet-2802	39	48	be	be	AUX
admet-2802	39	49	about	about	ADP
admet-2802	39	50	kpc,+1/	kpc,+1/	ADJ
admet-2802	39	51	kpc,0	kpc,0	PROPN
admet-2802	39	52	≈	≈	PROPN
admet-2802	39	53	1/10	1/10	NUM
admet-2802	39	54	and	and	CCONJ
admet-2802	39	55	kpc,-1/	kpc,-1/	PROPN
admet-2802	39	56	kpc,0	kpc,0	PROPN
admet-2802	39	57	≈	≈	PROPN
admet-2802	39	58	1/100	1/100	NUM
admet-2802	39	59	,	,	PUNCT
admet-2802	39	60	respectively	respectively	ADV
admet-2802	39	61	[	[	X
admet-2802	39	62	12	12	NUM
admet-2802	39	63	-	-	SYM
admet-2802	39	64	14	14	NUM
admet-2802	39	65	]	]	PUNCT
admet-2802	39	66	.	.	PUNCT
admet-2802	40	1	however	however	ADV
admet-2802	40	2	,	,	PUNCT
admet-2802	40	3	it	it	PRON
admet-2802	40	4	has	have	AUX
admet-2802	40	5	been	be	AUX
admet-2802	40	6	unknown	unknown	ADJ
admet-2802	40	7	whether	whether	SCONJ
admet-2802	40	8	there	there	PRON
admet-2802	40	9	is	be	VERB
admet-2802	40	10	such	such	DET
admet-2802	40	11	a	a	DET
admet-2802	40	12	general	general	ADJ
admet-2802	40	13	approximation	approximation	NOUN
admet-2802	40	14	rule	rule	NOUN
admet-2802	40	15	for	for	ADP
admet-2802	40	16	the	the	DET
admet-2802	40	17	bile	bile	NOUN
admet-2802	40	18	micelle	micelle	NOUN
admet-2802	40	19	partition	partition	PROPN
admet-2802	40	20	coefficient	coefficient	NOUN
admet-2802	40	21	.	.	PUNCT
admet-2802	41	1	previously	previously	ADV
admet-2802	41	2	,	,	PUNCT
admet-2802	41	3	schwartz	schwartz	PROPN
admet-2802	41	4	et	et	PROPN
admet-2802	41	5	al	al	PROPN
admet-2802	41	6	.	.	PROPN
admet-2802	41	7	investigated	investigate	VERB
admet-2802	41	8	the	the	DET
admet-2802	41	9	bile	bile	NOUN
admet-2802	41	10	micelle	micelle	NOUN
admet-2802	41	11	binding	bind	VERB
admet-2802	41	12	of	of	ADP
admet-2802	41	13	several	several	ADJ
admet-2802	41	14	ionizable	ionizable	ADJ
admet-2802	41	15	drugs	drug	NOUN
admet-2802	41	16	by	by	ADP
admet-2802	41	17	electrokinetic	electrokinetic	ADJ
admet-2802	41	18	capillary	capillary	ADJ
admet-2802	41	19	chromatography	chromatography	NOUN
admet-2802	41	20	at	at	ADP
admet-2802	41	21	ph	ph	PROPN
admet-2802	41	22	7.4	7.4	NUM
admet-2802	41	23	and	and	CCONJ
admet-2802	41	24	10	10	NUM
admet-2802	42	1	[	[	SYM
admet-2802	42	2	15	15	NUM
admet-2802	42	3	]	]	PUNCT
admet-2802	42	4	.	.	PUNCT
admet-2802	43	1	it	it	PRON
admet-2802	43	2	was	be	AUX
admet-2802	43	3	suggested	suggest	VERB
admet-2802	43	4	that	that	SCONJ
admet-2802	43	5	only	only	ADV
admet-2802	43	6	hydrophobic	hydrophobic	VERB
admet-2802	43	7	weak	weak	ADJ
admet-2802	43	8	base	base	NOUN
admet-2802	43	9	drugs	drug	NOUN
admet-2802	43	10	,	,	PUNCT
admet-2802	43	11	such	such	ADJ
admet-2802	43	12	as	as	ADP
admet-2802	43	13	quinine	quinine	NOUN
admet-2802	43	14	and	and	CCONJ
admet-2802	43	15	propranolol	propranolol	NOUN
admet-2802	43	16	,	,	PUNCT
admet-2802	43	17	can	can	AUX
admet-2802	43	18	interact	interact	VERB
admet-2802	43	19	with	with	ADP
admet-2802	43	20	bile	bile	NOUN
admet-2802	43	21	micelles	micelle	NOUN
admet-2802	43	22	.	.	PUNCT
admet-2802	44	1	castro	castro	PROPN
admet-2802	44	2	et	et	PROPN
admet-2802	44	3	al	al	PROPN
admet-2802	44	4	.	.	PROPN
admet-2802	44	5	investigated	investigate	VERB
admet-2802	44	6	the	the	DET
admet-2802	44	7	kbm	kbm	NOUN
admet-2802	44	8	of	of	ADP
admet-2802	44	9	atenolol	atenolol	PROPN
admet-2802	44	10	,	,	PUNCT
admet-2802	44	11	nadolol	nadolol	X
admet-2802	44	12	,	,	PUNCT
admet-2802	44	13	and	and	CCONJ
admet-2802	44	14	nitrazepam	nitrazepam	NOUN
admet-2802	44	15	at	at	ADP
admet-2802	44	16	ph	ph	PROPN
admet-2802	44	17	7.0	7.0	NUM
admet-2802	44	18	and	and	CCONJ
admet-2802	44	19	10.8	10.8	NUM
admet-2802	44	20	by	by	ADP
admet-2802	44	21	spectrofluorimetry	spectrofluorimetry	NOUN
admet-2802	44	22	and	and	CCONJ
admet-2802	44	23	derivative	derivative	ADJ
admet-2802	44	24	spectrophotometry	spectrophotometry	NOUN
admet-2802	44	25	[	[	X
admet-2802	44	26	16	16	NUM
admet-2802	44	27	]	]	PUNCT
admet-2802	44	28	.	.	PUNCT
admet-2802	45	1	in	in	ADP
admet-2802	45	2	those	those	DET
admet-2802	45	3	studies	study	NOUN
admet-2802	45	4	,	,	PUNCT
admet-2802	45	5	the	the	DET
admet-2802	45	6	kbm	kbm	NOUN
admet-2802	45	7	of	of	ADP
admet-2802	45	8	protonated	protonate	VERB
admet-2802	45	9	molecular	molecular	ADJ
admet-2802	45	10	species	specie	NOUN
admet-2802	45	11	(	(	PUNCT
admet-2802	45	12	kbm,+1	kbm,+1	NOUN
admet-2802	45	13	)	)	PUNCT
admet-2802	45	14	of	of	ADP
admet-2802	45	15	atenolol	atenolol	PROPN
admet-2802	45	16	and	and	CCONJ
admet-2802	45	17	nadolol	nadolol	PROPN
admet-2802	45	18	was	be	AUX
admet-2802	45	19	greater	great	ADJ
admet-2802	45	20	than	than	ADP
admet-2802	45	21	that	that	PRON
admet-2802	45	22	of	of	ADP
admet-2802	45	23	un	un	ADJ
admet-2802	45	24	-	-	ADJ
admet-2802	45	25	ionized	ionized	ADJ
admet-2802	45	26	species	specie	NOUN
admet-2802	45	27	(	(	PUNCT
admet-2802	45	28	kbm,0	kbm,0	PROPN
admet-2802	45	29	)	)	PUNCT
admet-2802	45	30	.	.	PUNCT
admet-2802	46	1	on	on	ADP
admet-2802	46	2	the	the	DET
admet-2802	46	3	other	other	ADJ
admet-2802	46	4	hand	hand	NOUN
admet-2802	46	5	,	,	PUNCT
admet-2802	46	6	the	the	DET
admet-2802	46	7	kbm	kbm	NOUN
admet-2802	46	8	of	of	ADP
admet-2802	46	9	the	the	DET
admet-2802	46	10	deprotonated	deprotonate	VERB
admet-2802	46	11	molecular	molecular	ADJ
admet-2802	46	12	species	specie	NOUN
admet-2802	46	13	of	of	ADP
admet-2802	46	14	nitrazepam	nitrazepam	NOUN
admet-2802	46	15	(	(	PUNCT
admet-2802	46	16	mono	mono	NOUN
admet-2802	46	17	-	-	PUNCT
admet-2802	46	18	anion	anion	NOUN
admet-2802	46	19	)	)	PUNCT
admet-2802	46	20	(	(	PUNCT
admet-2802	46	21	kbm,-1	kbm,-1	PROPN
admet-2802	46	22	)	)	PUNCT
admet-2802	46	23	was	be	AUX
admet-2802	46	24	markedly	markedly	ADV
admet-2802	46	25	less	less	ADJ
admet-2802	46	26	than	than	ADP
admet-2802	46	27	kbm,0	kbm,0	PROPN
admet-2802	46	28	.	.	PUNCT
admet-2802	47	1	however	however	ADV
admet-2802	47	2	,	,	PUNCT
admet-2802	47	3	the	the	DET
admet-2802	47	4	number	number	NOUN
admet-2802	47	5	of	of	ADP
admet-2802	47	6	drugs	drug	NOUN
admet-2802	47	7	was	be	AUX
admet-2802	47	8	not	not	PART
admet-2802	47	9	sufficient	sufficient	ADJ
admet-2802	47	10	to	to	PART
admet-2802	47	11	clarify	clarify	VERB
admet-2802	47	12	whether	whether	SCONJ
admet-2802	47	13	there	there	PRON
admet-2802	47	14	is	be	VERB
admet-2802	47	15	a	a	DET
admet-2802	47	16	general	general	ADJ
admet-2802	47	17	rule	rule	NOUN
admet-2802	47	18	for	for	ADP
admet-2802	47	19	kbm	kbm	PROPN
admet-2802	47	20	,	,	PUNCT
admet-2802	47	21	z≠0	z≠0	PROPN
admet-2802	47	22	/	/	SYM
admet-2802	47	23	kbm,0	kbm,0	PROPN
admet-2802	47	24	.	.	PUNCT
admet-2802	48	1	the	the	DET
admet-2802	48	2	purpose	purpose	NOUN
admet-2802	48	3	of	of	ADP
admet-2802	48	4	the	the	DET
admet-2802	48	5	present	present	ADJ
admet-2802	48	6	study	study	NOUN
admet-2802	48	7	was	be	AUX
admet-2802	48	8	to	to	PART
admet-2802	48	9	clarify	clarify	VERB
admet-2802	48	10	whether	whether	SCONJ
admet-2802	48	11	there	there	PRON
admet-2802	48	12	is	be	VERB
admet-2802	48	13	a	a	DET
admet-2802	48	14	general	general	ADJ
admet-2802	48	15	rule	rule	NOUN
admet-2802	48	16	for	for	ADP
admet-2802	48	17	the	the	DET
admet-2802	48	18	ratio	ratio	NOUN
admet-2802	48	19	of	of	ADP
admet-2802	48	20	kbm	kbm	PROPN
admet-2802	48	21	,	,	PUNCT
admet-2802	48	22	z≠0	z≠0	PROPN
admet-2802	48	23	/	/	SYM
admet-2802	48	24	kbm,0	kbm,0	PROPN
admet-2802	48	25	for	for	ADP
admet-2802	48	26	structurally	structurally	ADV
admet-2802	48	27	diverse	diverse	VERB
admet-2802	48	28	ionizable	ionizable	ADJ
admet-2802	48	29	drug	drug	NOUN
admet-2802	48	30	molecules	molecule	NOUN
admet-2802	48	31	.	.	PUNCT
admet-2802	49	1	four	four	NUM
admet-2802	49	2	monovalent	monovalent	NOUN
admet-2802	49	3	weak	weak	ADJ
admet-2802	49	4	acids	acid	NOUN
admet-2802	49	5	,	,	PUNCT
admet-2802	49	6	8	8	NUM
admet-2802	49	7	monovalent	monovalent	NOUN
admet-2802	49	8	weak	weak	ADJ
admet-2802	49	9	bases	basis	NOUN
admet-2802	49	10	,	,	PUNCT
admet-2802	49	11	2	2	NUM
admet-2802	49	12	divalent	divalent	NOUN
admet-2802	49	13	weak	weak	ADJ
admet-2802	49	14	bases	basis	NOUN
admet-2802	49	15	,	,	PUNCT
admet-2802	49	16	and	and	CCONJ
admet-2802	49	17	2	2	NUM
admet-2802	49	18	zwitterionic	zwitterionic	ADJ
admet-2802	49	19	drugs	drug	NOUN
admet-2802	49	20	were	be	AUX
admet-2802	49	21	employed	employ	VERB
admet-2802	49	22	as	as	ADP
admet-2802	49	23	model	model	NOUN
admet-2802	49	24	drugs	drug	NOUN
admet-2802	49	25	(	(	PUNCT
admet-2802	49	26	figure	figure	NOUN
admet-2802	49	27	1	1	NUM
admet-2802	49	28	)	)	PUNCT
admet-2802	49	29	.	.	PUNCT
admet-2802	50	1	the	the	DET
admet-2802	50	2	ph	ph	VERB
admet-2802	50	3	-	-	PUNCT
admet-2802	50	4	fu	fu	NOUN
admet-2802	50	5	profile	profile	NOUN
admet-2802	50	6	was	be	AUX
admet-2802	50	7	measured	measure	VERB
admet-2802	50	8	by	by	ADP
admet-2802	50	9	dynamic	dynamic	ADJ
admet-2802	50	10	dialysis	dialysis	NOUN
admet-2802	51	1	[	[	X
admet-2802	51	2	17,18	17,18	X
admet-2802	51	3	]	]	PUNCT
admet-2802	51	4	.	.	PUNCT
admet-2802	52	1	the	the	DET
admet-2802	52	2	fu	fu	PROPN
admet-2802	52	3	value	value	NOUN
admet-2802	52	4	was	be	AUX
admet-2802	52	5	measured	measure	VERB
admet-2802	52	6	in	in	ADP
admet-2802	52	7	the	the	DET
admet-2802	52	8	ph	ph	ADJ
admet-2802	52	9	range	range	NOUN
admet-2802	52	10	of	of	ADP
admet-2802	52	11	about	about	ADP
admet-2802	52	12	pka	pka	PROPN
admet-2802	52	13	±	±	NUM
admet-2802	52	14	2	2	NUM
admet-2802	52	15	.	.	PUNCT
admet-2802	53	1	the	the	DET
admet-2802	53	2	kbm	kbm	NOUN
admet-2802	53	3	,	,	PUNCT
admet-2802	53	4	z	z	NOUN
admet-2802	53	5	values	value	NOUN
admet-2802	53	6	were	be	AUX
admet-2802	53	7	calculated	calculate	VERB
admet-2802	53	8	from	from	ADP
admet-2802	53	9	the	the	DET
admet-2802	53	10	ph	ph	VERB
admet-2802	53	11	-	-	PUNCT
admet-2802	53	12	fu	fu	NOUN
admet-2802	53	13	profile	profile	NOUN
admet-2802	53	14	in	in	ADP
admet-2802	53	15	the	the	DET
admet-2802	53	16	fed	fed	PROPN
admet-2802	53	17	-	-	PUNCT
admet-2802	53	18	state	state	NOUN
admet-2802	53	19	simulated	simulate	VERB
admet-2802	53	20	intestinal	intestinal	ADJ
admet-2802	53	21	fluid	fluid	NOUN
admet-2802	53	22	(	(	PUNCT
admet-2802	53	23	fessif	fessif	NOUN
admet-2802	53	24	)	)	PUNCT
admet-2802	53	25	containing	contain	VERB
admet-2802	53	26	taurocholic	taurocholic	ADJ
admet-2802	53	27	acid	acid	NOUN
admet-2802	53	28	(	(	PUNCT
admet-2802	53	29	tc	tc	NOUN
admet-2802	53	30	)	)	PUNCT
admet-2802	53	31	(	(	PUNCT
admet-2802	53	32	15	15	NUM
admet-2802	53	33	mm	mm	NOUN
admet-2802	53	34	)	)	PUNCT
admet-2802	53	35	and	and	CCONJ
admet-2802	53	36	egg	egg	NOUN
admet-2802	53	37	lecithin	lecithin	NOUN
admet-2802	53	38	(	(	PUNCT
admet-2802	53	39	el	el	NOUN
admet-2802	53	40	)	)	PUNCT
admet-2802	53	41	(	(	PUNCT
admet-2802	53	42	3.75	3.75	NUM
admet-2802	53	43	mm	mm	NOUN
admet-2802	53	44	)	)	PUNCT
admet-2802	54	1	[	[	X
admet-2802	54	2	19	19	NUM
admet-2802	54	3	]	]	PUNCT
admet-2802	54	4	.	.	PUNCT
admet-2802	55	1	figure	figure	NOUN
admet-2802	55	2	1	1	NUM
admet-2802	55	3	.	.	PUNCT
admet-2802	56	1	chemical	chemical	NOUN
admet-2802	56	2	structures	structure	NOUN
admet-2802	56	3	of	of	ADP
admet-2802	56	4	model	model	NOUN
admet-2802	56	5	drugs	drug	NOUN
admet-2802	56	6	admet	admet	PROPN
admet-2802	56	7	&	&	CCONJ
admet-2802	56	8	dmpk	dmpk	PROPN
admet-2802	56	9	13(4	13(4	NUM
admet-2802	56	10	)	)	PUNCT
admet-2802	56	11	(	(	PUNCT
admet-2802	56	12	2025	2025	NUM
admet-2802	56	13	)	)	PUNCT
admet-2802	56	14	2802	2802	NUM
admet-2802	56	15	bile	bile	NOUN
admet-2802	56	16	micelle	micelle	NOUN
admet-2802	56	17	binding	bind	VERB
admet-2802	56	18	of	of	ADP
admet-2802	56	19	structurally	structurally	ADV
admet-2802	56	20	diverse	diverse	ADJ
admet-2802	56	21	ionized	ionized	ADJ
admet-2802	56	22	drugs	drug	NOUN
admet-2802	56	23	doi	doi	NOUN
admet-2802	56	24	:	:	PUNCT
admet-2802	56	25	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	56	26	3	3	NUM
admet-2802	56	27	table	table	NOUN
admet-2802	56	28	1	1	NUM
admet-2802	56	29	.	.	PUNCT
admet-2802	56	30	physicochemical	physicochemical	ADJ
admet-2802	56	31	properties	property	NOUN
admet-2802	56	32	of	of	ADP
admet-2802	56	33	model	model	NOUN
admet-2802	56	34	drugs	drug	NOUN
admet-2802	56	35	drug	drug	NOUN
admet-2802	56	36	mw	mw	AUX
admet-2802	56	37	pka	pka	PROPN
admet-2802	56	38	a	a	DET
admet-2802	56	39	log	log	NOUN
admet-2802	56	40	poct	poct	NOUN
admet-2802	56	41	ref	ref	NOUN
admet-2802	56	42	monovalent	monovalent	NOUN
admet-2802	56	43	weak	weak	ADJ
admet-2802	56	44	acid	acid	NOUN
admet-2802	56	45	drugs	drug	NOUN
admet-2802	56	46	flurbiprofen	flurbiprofen	VERB
admet-2802	56	47	244	244	NUM
admet-2802	56	48	4.18(a	4.18(a	NOUN
admet-2802	56	49	)	)	PUNCT
admet-2802	56	50	(	(	PUNCT
admet-2802	56	51	25	25	NUM
admet-2802	56	52	°	°	NOUN
admet-2802	56	53	c	c	NOUN
admet-2802	56	54	,	,	PUNCT
admet-2802	56	55	i	i	PRON
admet-2802	56	56	=	=	PROPN
admet-2802	56	57	0.16	0.16	NUM
admet-2802	56	58	m	m	NOUN
admet-2802	56	59	)	)	PUNCT
admet-2802	56	60	4.0	4.0	NUM
admet-2802	57	1	[	[	X
admet-2802	57	2	12	12	NUM
admet-2802	57	3	]	]	PUNCT
admet-2802	57	4	furosemide	furosemide	VERB
admet-2802	57	5	331	331	NUM
admet-2802	57	6	3.53(a	3.53(a	NUM
admet-2802	57	7	)	)	PUNCT
admet-2802	57	8	(	(	PUNCT
admet-2802	57	9	37	37	NUM
admet-2802	57	10	°	°	NOUN
admet-2802	57	11	c	c	NOUN
admet-2802	57	12	,	,	PUNCT
admet-2802	57	13	i	i	NOUN
admet-2802	57	14	=	=	PUNCT
admet-2802	57	15	0.15	0.15	NUM
admet-2802	57	16	m	m	PROPN
admet-2802	57	17	)	)	PUNCT
admet-2802	57	18	2.6	2.6	NUM
admet-2802	58	1	[	[	X
admet-2802	58	2	12	12	NUM
admet-2802	58	3	]	]	PUNCT
admet-2802	58	4	ibuprofen	ibuprofen	NOUN
admet-2802	58	5	206	206	NUM
admet-2802	58	6	4.35(a	4.35(a	NOUN
admet-2802	58	7	)	)	PUNCT
admet-2802	58	8	(	(	PUNCT
admet-2802	58	9	25	25	NUM
admet-2802	58	10	°	°	NOUN
admet-2802	58	11	c	c	NOUN
admet-2802	58	12	,	,	PUNCT
admet-2802	58	13	i	i	NOUN
admet-2802	58	14	=	=	PUNCT
admet-2802	58	15	0.15	0.15	NUM
admet-2802	58	16	m	m	PROPN
admet-2802	58	17	)	)	PUNCT
admet-2802	58	18	4.1	4.1	NUM
admet-2802	59	1	[	[	X
admet-2802	59	2	12	12	NUM
admet-2802	59	3	]	]	PUNCT
admet-2802	59	4	ketoprofen	ketoprofen	VERB
admet-2802	59	5	254	254	NUM
admet-2802	59	6	4.00(a	4.00(a	NUM
admet-2802	59	7	)	)	PUNCT
admet-2802	59	8	(	(	PUNCT
admet-2802	59	9	37	37	NUM
admet-2802	59	10	°	°	NOUN
admet-2802	59	11	c	c	NOUN
admet-2802	59	12	,	,	PUNCT
admet-2802	59	13	i	i	NOUN
admet-2802	59	14	=	=	PUNCT
admet-2802	59	15	0.15	0.15	NUM
admet-2802	59	16	m	m	PROPN
admet-2802	59	17	)	)	PUNCT
admet-2802	59	18	3.2	3.2	NUM
admet-2802	60	1	[	[	X
admet-2802	60	2	12	12	NUM
admet-2802	60	3	]	]	PUNCT
admet-2802	60	4	monovalent	monovalent	NOUN
admet-2802	60	5	weak	weak	ADJ
admet-2802	60	6	base	base	NOUN
admet-2802	60	7	drugs	drug	NOUN
admet-2802	60	8	diphenhydramine	diphenhydramine	NOUN
admet-2802	60	9	255	255	NUM
admet-2802	60	10	8.86(b	8.86(b	NUM
admet-2802	60	11	)	)	PUNCT
admet-2802	60	12	(	(	PUNCT
admet-2802	60	13	37	37	NUM
admet-2802	60	14	°	°	NOUN
admet-2802	60	15	c	c	NOUN
admet-2802	60	16	,	,	PUNCT
admet-2802	60	17	i	i	NOUN
admet-2802	60	18	=	=	PUNCT
admet-2802	60	19	0.15	0.15	NUM
admet-2802	60	20	m	m	PROPN
admet-2802	60	21	)	)	PUNCT
admet-2802	60	22	3.2	3.2	NUM
admet-2802	61	1	[	[	X
admet-2802	61	2	12	12	NUM
admet-2802	61	3	]	]	PUNCT
admet-2802	61	4	papaverine	papaverine	VERB
admet-2802	61	5	339	339	NUM
admet-2802	61	6	6.22(b	6.22(b	NUM
admet-2802	61	7	)	)	PUNCT
admet-2802	61	8	(	(	PUNCT
admet-2802	61	9	37	37	NUM
admet-2802	61	10	°	°	NOUN
admet-2802	61	11	c	c	NOUN
admet-2802	61	12	,	,	PUNCT
admet-2802	61	13	i	i	NOUN
admet-2802	61	14	=	=	PROPN
admet-2802	61	15	0.18	0.18	NUM
admet-2802	61	16	m	m	PROPN
admet-2802	61	17	)	)	PUNCT
admet-2802	61	18	3.0	3.0	NUM
admet-2802	62	1	[	[	X
admet-2802	62	2	12	12	NUM
admet-2802	62	3	]	]	PUNCT
admet-2802	62	4	propranolol	propranolol	X
admet-2802	62	5	259	259	NUM
admet-2802	62	6	9.16(b	9.16(b	NUM
admet-2802	62	7	)	)	PUNCT
admet-2802	62	8	(	(	PUNCT
admet-2802	62	9	37	37	NUM
admet-2802	62	10	°	°	NOUN
admet-2802	62	11	c	c	NOUN
admet-2802	62	12	,	,	PUNCT
admet-2802	62	13	i	i	NOUN
admet-2802	62	14	=	=	PUNCT
admet-2802	62	15	0.15	0.15	NUM
admet-2802	62	16	m	m	PROPN
admet-2802	62	17	)	)	PUNCT
admet-2802	62	18	3.5	3.5	NUM
admet-2802	63	1	[	[	X
admet-2802	63	2	12	12	NUM
admet-2802	63	3	]	]	PUNCT
admet-2802	63	4	pyrimethamine	pyrimethamine	NOUN
admet-2802	63	5	249	249	NUM
admet-2802	63	6	7.36(b	7.36(b	NUM
admet-2802	63	7	)	)	PUNCT
admet-2802	64	1	b	b	NOUN
admet-2802	64	2	2.7	2.7	NUM
admet-2802	64	3	[	[	SYM
admet-2802	64	4	20	20	NUM
admet-2802	64	5	]	]	PUNCT
admet-2802	64	6	talinolol	talinolol	NOUN
admet-2802	64	7	363	363	NUM
admet-2802	64	8	9.4	9.4	NUM
admet-2802	64	9	(	(	PUNCT
admet-2802	64	10	b	b	NOUN
admet-2802	64	11	)	)	PUNCT
admet-2802	64	12	b	b	NOUN
admet-2802	64	13	3.1	3.1	NUM
admet-2802	64	14	[	[	SYM
admet-2802	64	15	21	21	NUM
admet-2802	64	16	]	]	PUNCT
admet-2802	64	17	tamsulosin	tamsulosin	NOUN
admet-2802	64	18	409	409	NUM
admet-2802	64	19	8.37(b	8.37(b	NUM
admet-2802	64	20	)	)	PUNCT
admet-2802	64	21	b	b	NOUN
admet-2802	64	22	2.0	2.0	NUM
admet-2802	64	23	[	[	SYM
admet-2802	64	24	22	22	NUM
admet-2802	64	25	]	]	PUNCT
admet-2802	64	26	verapamil	verapamil	NOUN
admet-2802	64	27	455	455	NUM
admet-2802	64	28	8.68(b	8.68(b	NUM
admet-2802	64	29	)	)	PUNCT
admet-2802	64	30	(	(	PUNCT
admet-2802	64	31	37	37	NUM
admet-2802	64	32	°	°	NOUN
admet-2802	64	33	c	c	NOUN
admet-2802	64	34	,	,	PUNCT
admet-2802	64	35	i	i	NOUN
admet-2802	64	36	=	=	PROPN
admet-2802	64	37	0.19	0.19	NUM
admet-2802	64	38	m	m	NOUN
admet-2802	64	39	)	)	PUNCT
admet-2802	64	40	4.3	4.3	NUM
admet-2802	65	1	[	[	X
admet-2802	65	2	12	12	NUM
admet-2802	65	3	]	]	PUNCT
admet-2802	65	4	vibegron	vibegron	NOUN
admet-2802	65	5	445	445	NUM
admet-2802	65	6	8.9(b	8.9(b	NUM
admet-2802	65	7	)	)	PUNCT
admet-2802	65	8	b	b	NOUN
admet-2802	65	9	3.1	3.1	NUM
admet-2802	65	10	[	[	SYM
admet-2802	65	11	23	23	NUM
admet-2802	65	12	]	]	X
admet-2802	65	13	divalent	divalent	ADJ
admet-2802	65	14	weak	weak	ADJ
admet-2802	65	15	base	base	NOUN
admet-2802	65	16	drugs	drug	NOUN
admet-2802	65	17	quinidine	quinidine	VERB
admet-2802	65	18	324	324	NUM
admet-2802	65	19	4.09(b	4.09(b	NUM
admet-2802	65	20	)	)	PUNCT
admet-2802	65	21	,	,	PUNCT
admet-2802	65	22	8.55(b	8.55(b	PROPN
admet-2802	65	23	)	)	PUNCT
admet-2802	65	24	b	b	NOUN
admet-2802	65	25	3.6	3.6	NUM
admet-2802	65	26	[	[	SYM
admet-2802	65	27	12	12	NUM
admet-2802	65	28	]	]	PUNCT
admet-2802	65	29	quinine	quinine	NOUN
admet-2802	65	30	324	324	NUM
admet-2802	65	31	4.35	4.35	NUM
admet-2802	65	32	(	(	PUNCT
admet-2802	65	33	b	b	NOUN
admet-2802	65	34	)	)	PUNCT
admet-2802	65	35	,	,	PUNCT
admet-2802	65	36	8.57	8.57	NUM
admet-2802	65	37	(	(	PUNCT
admet-2802	65	38	b	b	NOUN
admet-2802	65	39	)	)	PUNCT
admet-2802	65	40	(	(	PUNCT
admet-2802	65	41	26	26	NUM
admet-2802	65	42	°	°	SYM
admet-2802	65	43	c	c	NOUN
admet-2802	65	44	,	,	PUNCT
admet-2802	65	45	i	i	NOUN
admet-2802	65	46	=	=	PUNCT
admet-2802	65	47	0.15	0.15	NUM
admet-2802	65	48	m	m	PROPN
admet-2802	65	49	)	)	PUNCT
admet-2802	65	50	3.5	3.5	NUM
admet-2802	66	1	[	[	X
admet-2802	66	2	12	12	NUM
admet-2802	66	3	]	]	PUNCT
admet-2802	66	4	zwitterionic	zwitterionic	ADJ
admet-2802	66	5	drugs	drug	NOUN
admet-2802	66	6	cetirizine	cetirizine	VERB
admet-2802	66	7	389	389	NUM
admet-2802	66	8	2.12(b	2.12(b	NUM
admet-2802	66	9	)	)	PUNCT
admet-2802	66	10	,	,	PUNCT
admet-2802	66	11	2.90(a	2.90(a	NUM
admet-2802	66	12	)	)	PUNCT
admet-2802	66	13	,	,	PUNCT
admet-2802	66	14	7.98(b	7.98(b	NUM
admet-2802	66	15	)	)	PUNCT
admet-2802	66	16	(	(	PUNCT
admet-2802	66	17	25	25	NUM
admet-2802	66	18	°	°	NOUN
admet-2802	66	19	c	c	NOUN
admet-2802	66	20	,	,	PUNCT
admet-2802	66	21	i	i	NOUN
admet-2802	66	22	=	=	PUNCT
admet-2802	66	23	0.15	0.15	NUM
admet-2802	66	24	m	m	PROPN
admet-2802	66	25	)	)	PUNCT
admet-2802	66	26	1.46	1.46	NUM
admet-2802	66	27	c	c	NOUN
admet-2802	67	1	[	[	X
admet-2802	67	2	12	12	NUM
admet-2802	67	3	]	]	PUNCT
admet-2802	67	4	olopatadine	olopatadine	NOUN
admet-2802	67	5	337	337	NUM
admet-2802	67	6	4.18	4.18	NUM
admet-2802	67	7	(	(	PUNCT
admet-2802	67	8	a	a	NOUN
admet-2802	67	9	)	)	PUNCT
admet-2802	67	10	,	,	PUNCT
admet-2802	67	11	9.79	9.79	NUM
admet-2802	67	12	(	(	PUNCT
admet-2802	67	13	b	b	NOUN
admet-2802	67	14	)	)	PUNCT
admet-2802	67	15	b	b	NOUN
admet-2802	67	16	0.34	0.34	NUM
admet-2802	67	17	c	c	NOUN
admet-2802	68	1	[	[	X
admet-2802	68	2	24	24	NUM
admet-2802	68	3	]	]	X
admet-2802	68	4	aa	aa	NOUN
admet-2802	68	5	:	:	PUNCT
admet-2802	68	6	acid	acid	ADJ
admet-2802	68	7	,	,	PUNCT
admet-2802	68	8	b	b	NOUN
admet-2802	68	9	:	:	PUNCT
admet-2802	68	10	base	base	NOUN
admet-2802	68	11	;	;	PUNCT
admet-2802	68	12	btemperature	btemperature	NOUN
admet-2802	68	13	and	and	CCONJ
admet-2802	68	14	ionic	ionic	ADJ
admet-2802	68	15	strength	strength	NOUN
admet-2802	68	16	were	be	AUX
admet-2802	68	17	not	not	PART
admet-2802	68	18	reported	report	VERB
admet-2802	68	19	;	;	PUNCT
admet-2802	68	20	coctanol	coctanol	NOUN
admet-2802	68	21	-	-	PUNCT
admet-2802	68	22	water	water	NOUN
admet-2802	68	23	distribution	distribution	NOUN
admet-2802	68	24	coefficient	coefficient	NOUN
admet-2802	68	25	at	at	ADP
admet-2802	68	26	ph	ph	PROPN
admet-2802	68	27	6.5	6.5	NUM
admet-2802	69	1	[	[	X
admet-2802	69	2	25	25	NUM
admet-2802	69	3	]	]	PUNCT
admet-2802	69	4	.	.	PUNCT
admet-2802	70	1	experimental	experimental	ADJ
admet-2802	70	2	material	material	NOUN
admet-2802	70	3	diphenhydramine	diphenhydramine	NOUN
admet-2802	70	4	hydrochloride	hydrochloride	NOUN
admet-2802	70	5	,	,	PUNCT
admet-2802	70	6	ibuprofen	ibuprofen	NOUN
admet-2802	70	7	,	,	PUNCT
admet-2802	70	8	ketoprofen	ketoprofen	NOUN
admet-2802	70	9	,	,	PUNCT
admet-2802	70	10	papaverine	papaverine	ADJ
admet-2802	70	11	hydrochloride	hydrochloride	NOUN
admet-2802	70	12	,	,	PUNCT
admet-2802	70	13	propranolol	propranolol	NOUN
admet-2802	70	14	hydrochloride	hydrochloride	NOUN
admet-2802	70	15	,	,	PUNCT
admet-2802	70	16	quinidine	quinidine	ADJ
admet-2802	70	17	sulphate	sulphate	NOUN
admet-2802	70	18	dihydrate	dihydrate	NOUN
admet-2802	70	19	,	,	PUNCT
admet-2802	70	20	quinine	quinine	NOUN
admet-2802	70	21	,	,	PUNCT
admet-2802	70	22	sodium	sodium	NOUN
admet-2802	70	23	taurocholic	taurocholic	ADJ
admet-2802	70	24	acid	acid	NOUN
admet-2802	70	25	(	(	PUNCT
admet-2802	70	26	tc	tc	NOUN
admet-2802	70	27	)	)	PUNCT
admet-2802	70	28	,	,	PUNCT
admet-2802	70	29	sodium	sodium	NOUN
admet-2802	70	30	chloride	chloride	NOUN
admet-2802	70	31	,	,	PUNCT
admet-2802	70	32	sodium	sodium	NOUN
admet-2802	70	33	dihydrogen	dihydrogen	NOUN
admet-2802	70	34	phosphate	phosphate	NOUN
admet-2802	70	35	dihydrate	dihydrate	NOUN
admet-2802	70	36	,	,	PUNCT
admet-2802	70	37	6	6	NUM
admet-2802	70	38	m	m	NOUN
admet-2802	70	39	hcl	hcl	NOUN
admet-2802	70	40	,	,	PUNCT
admet-2802	70	41	and	and	CCONJ
admet-2802	70	42	8	8	NUM
admet-2802	70	43	m	m	NOUN
admet-2802	70	44	naoh	naoh	NOUN
admet-2802	70	45	were	be	AUX
admet-2802	70	46	purchased	purchase	VERB
admet-2802	70	47	from	from	ADP
admet-2802	70	48	fujifilm	fujifilm	PROPN
admet-2802	70	49	wako	wako	PROPN
admet-2802	70	50	pure	pure	PROPN
admet-2802	70	51	chemical	chemical	PROPN
admet-2802	70	52	corporation	corporation	NOUN
admet-2802	70	53	(	(	PUNCT
admet-2802	70	54	osaka	osaka	PROPN
admet-2802	70	55	,	,	PUNCT
admet-2802	70	56	japan	japan	PROPN
admet-2802	70	57	)	)	PUNCT
admet-2802	70	58	.	.	PUNCT
admet-2802	71	1	cetirizine	cetirizine	PROPN
admet-2802	71	2	dihydrochloride	dihydrochloride	NOUN
admet-2802	71	3	,	,	PUNCT
admet-2802	71	4	tamsulosin	tamsulosin	NOUN
admet-2802	71	5	hydrochloride	hydrochloride	NOUN
admet-2802	71	6	,	,	PUNCT
admet-2802	71	7	pyrimethamine	pyrimethamine	NOUN
admet-2802	71	8	,	,	PUNCT
admet-2802	71	9	flurbiprofen	flurbiprofen	NOUN
admet-2802	71	10	,	,	PUNCT
admet-2802	71	11	furosemide	furosemide	ADJ
admet-2802	71	12	,	,	PUNCT
admet-2802	71	13	olopatadine	olopatadine	ADJ
admet-2802	71	14	hydrochloride	hydrochloride	NOUN
admet-2802	71	15	,	,	PUNCT
admet-2802	71	16	talinolol	talinolol	NOUN
admet-2802	71	17	,	,	PUNCT
admet-2802	71	18	and	and	CCONJ
admet-2802	71	19	verapamil	verapamil	NOUN
admet-2802	71	20	hydrochloride	hydrochloride	NOUN
admet-2802	71	21	were	be	AUX
admet-2802	71	22	purchased	purchase	VERB
admet-2802	71	23	from	from	ADP
admet-2802	71	24	tokyo	tokyo	PROPN
admet-2802	71	25	chemical	chemical	PROPN
admet-2802	71	26	industry	industry	PROPN
admet-2802	71	27	co.	co.	PROPN
admet-2802	71	28	,	,	PUNCT
admet-2802	71	29	ltd	ltd	PROPN
admet-2802	71	30	(	(	PUNCT
admet-2802	71	31	tokyo	tokyo	PROPN
admet-2802	71	32	,	,	PUNCT
admet-2802	71	33	japan	japan	PROPN
admet-2802	71	34	)	)	PUNCT
admet-2802	71	35	.	.	PUNCT
admet-2802	72	1	vibegron	vibegron	PROPN
admet-2802	72	2	was	be	AUX
admet-2802	72	3	extracted	extract	VERB
admet-2802	72	4	from	from	ADP
admet-2802	72	5	the	the	DET
admet-2802	72	6	beova	beova	PROPN
admet-2802	72	7	tablet	tablet	PROPN
admet-2802	72	8	purchased	purchase	VERB
admet-2802	72	9	from	from	ADP
admet-2802	72	10	kyorin	kyorin	PROPN
admet-2802	72	11	pharmaceutical	pharmaceutical	PROPN
admet-2802	72	12	co.	co.	PROPN
admet-2802	72	13	,	,	PUNCT
admet-2802	72	14	ltd	ltd	PROPN
admet-2802	72	15	(	(	PUNCT
admet-2802	72	16	tokyo	tokyo	PROPN
admet-2802	72	17	,	,	PUNCT
admet-2802	72	18	japan	japan	PROPN
admet-2802	72	19	)	)	PUNCT
admet-2802	72	20	.	.	PUNCT
admet-2802	73	1	egg	egg	NOUN
admet-2802	73	2	yolk	yolk	NOUN
admet-2802	73	3	lecithin	lecithin	NOUN
admet-2802	73	4	(	(	PUNCT
admet-2802	73	5	el	el	NOUN
admet-2802	73	6	)	)	PUNCT
admet-2802	73	7	was	be	AUX
admet-2802	73	8	purchased	purchase	VERB
admet-2802	73	9	from	from	ADP
admet-2802	73	10	kewpie	kewpie	PROPN
admet-2802	73	11	corporation	corporation	PROPN
admet-2802	73	12	(	(	PUNCT
admet-2802	73	13	tokyo	tokyo	PROPN
admet-2802	73	14	,	,	PUNCT
admet-2802	73	15	japan	japan	PROPN
admet-2802	73	16	)	)	PUNCT
admet-2802	73	17	.	.	PUNCT
admet-2802	74	1	a	a	DET
admet-2802	74	2	cellulose	cellulose	NOUN
admet-2802	74	3	dialysis	dialysis	NOUN
admet-2802	74	4	membrane	membrane	NOUN
admet-2802	74	5	(	(	PUNCT
admet-2802	74	6	mwco	mwco	NOUN
admet-2802	74	7	3500	3500	NUM
admet-2802	74	8	)	)	PUNCT
admet-2802	74	9	was	be	AUX
admet-2802	74	10	purchased	purchase	VERB
admet-2802	74	11	from	from	ADP
admet-2802	74	12	as	as	ADP
admet-2802	74	13	-	-	PUNCT
admet-2802	74	14	one	one	NUM
admet-2802	74	15	corporation	corporation	NOUN
admet-2802	74	16	(	(	PUNCT
admet-2802	74	17	osaka	osaka	PROPN
admet-2802	74	18	,	,	PUNCT
admet-2802	74	19	japan	japan	PROPN
admet-2802	74	20	)	)	PUNCT
admet-2802	74	21	.	.	PUNCT
admet-2802	75	1	methods	method	NOUN
admet-2802	75	2	measurement	measurement	NOUN
admet-2802	75	3	of	of	ADP
admet-2802	75	4	the	the	DET
admet-2802	75	5	unbound	unbound	NOUN
admet-2802	75	6	fraction	fraction	NOUN
admet-2802	75	7	by	by	ADP
admet-2802	75	8	dynamic	dynamic	ADJ
admet-2802	75	9	dialysis	dialysis	NOUN
admet-2802	75	10	the	the	DET
admet-2802	75	11	fu	fu	NOUN
admet-2802	75	12	value	value	NOUN
admet-2802	75	13	was	be	AUX
admet-2802	75	14	measured	measure	VERB
admet-2802	75	15	by	by	ADP
admet-2802	75	16	dynamic	dynamic	ADJ
admet-2802	75	17	dialysis	dialysis	NOUN
admet-2802	75	18	using	use	VERB
admet-2802	75	19	a	a	DET
admet-2802	75	20	side	side	NOUN
admet-2802	75	21	-	-	PUNCT
admet-2802	75	22	by	by	ADP
admet-2802	75	23	-	-	PUNCT
admet-2802	75	24	side	side	NOUN
admet-2802	75	25	chamber	chamber	NOUN
admet-2802	75	26	(	(	PUNCT
admet-2802	75	27	sanplatec	sanplatec	PROPN
admet-2802	75	28	co.	co.	PROPN
admet-2802	75	29	,	,	PUNCT
admet-2802	75	30	ltd	ltd	PROPN
admet-2802	75	31	,	,	PUNCT
admet-2802	75	32	osaka	osaka	PROPN
admet-2802	75	33	,	,	PUNCT
admet-2802	75	34	japan	japan	PROPN
admet-2802	75	35	)	)	PUNCT
admet-2802	75	36	as	as	SCONJ
admet-2802	75	37	previously	previously	ADV
admet-2802	75	38	reported	report	VERB
admet-2802	75	39	[	[	X
admet-2802	75	40	25,26	25,26	NUM
admet-2802	75	41	]	]	X
admet-2802	75	42	.	.	PUNCT
admet-2802	76	1	the	the	DET
admet-2802	76	2	area	area	NOUN
admet-2802	76	3	of	of	ADP
admet-2802	76	4	the	the	DET
admet-2802	76	5	dialysis	dialysis	NOUN
admet-2802	76	6	membrane	membrane	NOUN
admet-2802	76	7	was	be	AUX
admet-2802	76	8	2.0	2.0	NUM
admet-2802	76	9	cm2	cm2	NOUN
admet-2802	76	10	.	.	PUNCT
admet-2802	77	1	the	the	DET
admet-2802	77	2	fluid	fluid	ADJ
admet-2802	77	3	volume	volume	NOUN
admet-2802	77	4	was	be	AUX
admet-2802	77	5	1.5	1.5	NUM
admet-2802	77	6	ml	ml	NOUN
admet-2802	77	7	in	in	ADP
admet-2802	77	8	both	both	CCONJ
admet-2802	77	9	the	the	DET
admet-2802	77	10	donor	donor	NOUN
admet-2802	77	11	and	and	CCONJ
admet-2802	77	12	acceptor	acceptor	NOUN
admet-2802	77	13	chambers	chamber	NOUN
admet-2802	77	14	.	.	PUNCT
admet-2802	78	1	the	the	DET
admet-2802	78	2	bile	bile	NOUN
admet-2802	78	3	micelle	micelle	NOUN
admet-2802	78	4	media	medium	NOUN
admet-2802	78	5	consisted	consist	VERB
admet-2802	78	6	of	of	ADP
admet-2802	78	7	tc	tc	PROPN
admet-2802	78	8	/	/	SYM
admet-2802	78	9	el	el	PROPN
admet-2802	78	10	(	(	PUNCT
admet-2802	78	11	15	15	NUM
admet-2802	78	12	/	/	SYM
admet-2802	78	13	3.75	3.75	NUM
admet-2802	78	14	mm	mm	NOUN
admet-2802	78	15	)	)	PUNCT
admet-2802	78	16	and	and	CCONJ
admet-2802	78	17	phosphate	phosphate	ADJ
admet-2802	78	18	buffer	buffer	NOUN
admet-2802	78	19	(	(	PUNCT
admet-2802	78	20	28.6	28.6	NUM
admet-2802	78	21	mm	mm	NOUN
admet-2802	78	22	phosphate	phosphate	NOUN
admet-2802	78	23	,	,	PUNCT
admet-2802	78	24	106	106	NUM
admet-2802	78	25	mm	mm	NOUN
admet-2802	78	26	nacl	nacl	NOUN
admet-2802	78	27	)	)	PUNCT
admet-2802	78	28	.	.	PUNCT
admet-2802	79	1	the	the	DET
admet-2802	79	2	ph	ph	ADJ
admet-2802	79	3	value	value	NOUN
admet-2802	79	4	was	be	AUX
admet-2802	79	5	adjusted	adjust	VERB
admet-2802	79	6	by	by	ADP
admet-2802	79	7	naoh	naoh	NOUN
admet-2802	79	8	in	in	ADP
admet-2802	79	9	the	the	DET
admet-2802	79	10	range	range	NOUN
admet-2802	79	11	of	of	ADP
admet-2802	79	12	about	about	ADP
admet-2802	79	13	pka±2	pka±2	PROPN
admet-2802	79	14	(	(	PUNCT
admet-2802	79	15	9615s-10d	9615s-10d	NUM
admet-2802	79	16	standard	standard	ADJ
admet-2802	79	17	touph	touph	ADJ
admet-2802	79	18	electrode	electrode	NOUN
admet-2802	79	19	,	,	PUNCT
admet-2802	79	20	horiba	horiba	VERB
admet-2802	79	21	advanced	advanced	ADJ
admet-2802	79	22	techno	techno	NOUN
admet-2802	79	23	,	,	PUNCT
admet-2802	79	24	co.	co.	PROPN
admet-2802	79	25	,	,	PUNCT
admet-2802	79	26	ltd	ltd	PROPN
admet-2802	79	27	.	.	PROPN
admet-2802	79	28	,	,	PUNCT
admet-2802	79	29	kyoto	kyoto	PROPN
admet-2802	79	30	,	,	PUNCT
admet-2802	79	31	japan	japan	PROPN
admet-2802	79	32	)	)	PUNCT
admet-2802	79	33	.	.	PUNCT
admet-2802	80	1	a	a	DET
admet-2802	80	2	drug	drug	NOUN
admet-2802	80	3	solution	solution	NOUN
admet-2802	80	4	with	with	ADP
admet-2802	80	5	or	or	CCONJ
admet-2802	80	6	without	without	ADP
admet-2802	80	7	bile	bile	NOUN
admet-2802	80	8	micelles	micelle	NOUN
admet-2802	80	9	at	at	ADP
admet-2802	80	10	each	each	DET
admet-2802	80	11	ph	ph	NOUN
admet-2802	80	12	(	(	PUNCT
admet-2802	80	13	1.5	1.5	NUM
admet-2802	80	14	ml	ml	NOUN
admet-2802	80	15	)	)	PUNCT
admet-2802	80	16	was	be	AUX
admet-2802	80	17	added	add	VERB
admet-2802	80	18	to	to	ADP
admet-2802	80	19	the	the	DET
admet-2802	80	20	donor	donor	NOUN
admet-2802	80	21	chamber	chamber	PROPN
admet-2802	80	22	.	.	PUNCT
admet-2802	81	1	the	the	DET
admet-2802	81	2	initial	initial	ADJ
admet-2802	81	3	donor	donor	NOUN
admet-2802	81	4	concentration	concentration	NOUN
admet-2802	81	5	of	of	ADP
admet-2802	81	6	each	each	DET
admet-2802	81	7	drug	drug	NOUN
admet-2802	81	8	is	be	AUX
admet-2802	81	9	shown	show	VERB
admet-2802	81	10	in	in	ADP
admet-2802	81	11	supplementary	supplementary	ADJ
admet-2802	81	12	material	material	NOUN
admet-2802	81	13	(	(	PUNCT
admet-2802	81	14	sm	sm	NOUN
admet-2802	81	15	)	)	PUNCT
admet-2802	81	16	table	table	NOUN
admet-2802	81	17	s1	s1	NOUN
admet-2802	81	18	.	.	PUNCT
admet-2802	82	1	a	a	DET
admet-2802	82	2	blank	blank	ADJ
admet-2802	82	3	phosphate	phosphate	NOUN
admet-2802	82	4	buffer	buffer	NOUN
admet-2802	82	5	solution	solution	NOUN
admet-2802	82	6	(	(	PUNCT
admet-2802	82	7	same	same	ADJ
admet-2802	82	8	ph	ph	NOUN
admet-2802	82	9	)	)	PUNCT
admet-2802	82	10	without	without	ADP
admet-2802	82	11	a	a	DET
admet-2802	82	12	drug	drug	NOUN
admet-2802	82	13	and	and	CCONJ
admet-2802	82	14	bile	bile	NOUN
admet-2802	82	15	micelles	micelle	NOUN
admet-2802	82	16	(	(	PUNCT
admet-2802	82	17	1.5	1.5	NUM
admet-2802	82	18	ml	ml	NOUN
admet-2802	82	19	)	)	PUNCT
admet-2802	82	20	was	be	AUX
admet-2802	82	21	added	add	VERB
admet-2802	82	22	to	to	ADP
admet-2802	82	23	the	the	DET
admet-2802	82	24	acceptor	acceptor	NOUN
admet-2802	82	25	chamber	chamber	NOUN
admet-2802	82	26	.	.	PUNCT
admet-2802	83	1	after	after	ADP
admet-2802	83	2	incubation	incubation	NOUN
admet-2802	83	3	for	for	ADP
admet-2802	83	4	1.0	1.0	NUM
admet-2802	83	5	h	h	NOUN
admet-2802	83	6	at	at	ADP
admet-2802	83	7	37	37	NUM
admet-2802	83	8	°	°	NOUN
admet-2802	83	9	c	c	NOUN
admet-2802	83	10	,	,	PUNCT
admet-2802	83	11	the	the	DET
admet-2802	83	12	drug	drug	NOUN
admet-2802	83	13	concentration	concentration	NOUN
admet-2802	83	14	in	in	ADP
admet-2802	83	15	the	the	DET
admet-2802	83	16	acceptor	acceptor	NOUN
admet-2802	83	17	chamber	chamber	NOUN
admet-2802	83	18	was	be	AUX
admet-2802	83	19	measured	measure	VERB
admet-2802	83	20	by	by	ADP
admet-2802	83	21	hplc	hplc	NOUN
admet-2802	83	22	(	(	PUNCT
admet-2802	83	23	shimazu	shimazu	ADJ
admet-2802	83	24	prominence	prominence	NOUN
admet-2802	83	25	lc-20	lc-20	PRON
admet-2802	83	26	series	series	NOUN
admet-2802	83	27	,	,	PUNCT
admet-2802	83	28	column	column	NOUN
admet-2802	83	29	:	:	PUNCT
admet-2802	83	30	zorbax	zorbax	PROPN
admet-2802	83	31	eclipse	eclipse	PROPN
admet-2802	83	32	plus	plus	CCONJ
admet-2802	83	33	(	(	PUNCT
admet-2802	83	34	c18	c18	NOUN
admet-2802	83	35	2.1×50	2.1×50	NUM
admet-2802	83	36	mm	mm	PROPN
admet-2802	83	37	,	,	PUNCT
admet-2802	83	38	3.5	3.5	NUM
admet-2802	83	39	µm	µm	NOUN
admet-2802	83	40	)	)	PUNCT
admet-2802	83	41	(	(	PUNCT
admet-2802	83	42	agilent	agilent	PROPN
admet-2802	83	43	technologies	technology	NOUN
admet-2802	83	44	)	)	PUNCT
admet-2802	83	45	,	,	PUNCT
admet-2802	83	46	flow	flow	NOUN
admet-2802	83	47	rate	rate	NOUN
admet-2802	83	48	:	:	PUNCT
admet-2802	83	49	0.6	0.6	NUM
admet-2802	83	50	ml	ml	NOUN
admet-2802	83	51	min-1	min-1	PROPN
admet-2802	83	52	,	,	PUNCT
admet-2802	83	53	column	column	NOUN
admet-2802	83	54	temperature	temperature	NOUN
admet-2802	83	55	:	:	PUNCT
admet-2802	83	56	40	40	NUM
admet-2802	83	57	°	°	NOUN
admet-2802	83	58	c	c	VERB
admet-2802	83	59	,	,	PUNCT
admet-2802	83	60	and	and	CCONJ
admet-2802	83	61	injection	injection	NOUN
admet-2802	83	62	volume	volume	NOUN
admet-2802	83	63	of	of	ADP
admet-2802	83	64	10	10	NUM
admet-2802	83	65	µl	µl	NOUN
admet-2802	83	66	)	)	PUNCT
admet-2802	83	67	.	.	PUNCT
admet-2802	84	1	the	the	DET
admet-2802	84	2	mobile	mobile	ADJ
admet-2802	84	3	phase	phase	NOUN
admet-2802	84	4	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	PROPN
admet-2802	84	5	m.	m.	NOUN
admet-2802	84	6	konishi	konishi	PROPN
admet-2802	84	7	and	and	CCONJ
admet-2802	84	8	k.	k.	PROPN
admet-2802	84	9	sugano	sugano	PROPN
admet-2802	84	10	admet	admet	PROPN
admet-2802	84	11	&	&	CCONJ
admet-2802	84	12	dmpk	dmpk	PROPN
admet-2802	84	13	13(4	13(4	NUM
admet-2802	84	14	)	)	PUNCT
admet-2802	84	15	(	(	PUNCT
admet-2802	84	16	2025	2025	NUM
admet-2802	84	17	)	)	PUNCT
admet-2802	84	18	2802	2802	NUM
admet-2802	84	19	4	4	NUM
admet-2802	84	20	composition	composition	NOUN
admet-2802	84	21	and	and	CCONJ
admet-2802	84	22	the	the	DET
admet-2802	84	23	detection	detection	NOUN
admet-2802	84	24	wavelength	wavelength	NOUN
admet-2802	84	25	are	be	AUX
admet-2802	84	26	listed	list	VERB
admet-2802	84	27	in	in	ADP
admet-2802	84	28	sm	sm	PROPN
admet-2802	84	29	table	table	NOUN
admet-2802	84	30	s2	s2	PROPN
admet-2802	84	31	.	.	PUNCT
admet-2802	85	1	the	the	DET
admet-2802	85	2	determination	determination	NOUN
admet-2802	85	3	coefficient	coefficient	NOUN
admet-2802	85	4	of	of	ADP
admet-2802	85	5	the	the	DET
admet-2802	85	6	standard	standard	ADJ
admet-2802	85	7	curves	curve	NOUN
admet-2802	85	8	was	be	AUX
admet-2802	85	9	greater	great	ADJ
admet-2802	85	10	than	than	ADP
admet-2802	85	11	0.999	0.999	NUM
admet-2802	85	12	in	in	ADP
admet-2802	85	13	all	all	DET
admet-2802	85	14	cases	case	NOUN
admet-2802	85	15	.	.	PUNCT
admet-2802	86	1	permeation	permeation	NOUN
admet-2802	86	2	,	,	PUNCT
admet-2802	86	3	%	%	NOUN
admet-2802	86	4	was	be	AUX
admet-2802	86	5	calculated	calculate	VERB
admet-2802	86	6	as	as	ADP
admet-2802	86	7	the	the	DET
admet-2802	86	8	ratio	ratio	NOUN
admet-2802	86	9	of	of	ADP
admet-2802	86	10	the	the	DET
admet-2802	86	11	concentrations	concentration	NOUN
admet-2802	86	12	in	in	ADP
admet-2802	86	13	the	the	DET
admet-2802	86	14	acceptor	acceptor	NOUN
admet-2802	86	15	chamber	chamber	NOUN
admet-2802	86	16	at	at	ADP
admet-2802	86	17	1.0	1.0	NUM
admet-2802	86	18	h	h	NOUN
admet-2802	86	19	and	and	CCONJ
admet-2802	86	20	the	the	DET
admet-2802	86	21	theoretical	theoretical	ADJ
admet-2802	86	22	equilibrium	equilibrium	NOUN
admet-2802	86	23	concentration	concentration	NOUN
admet-2802	86	24	in	in	ADP
admet-2802	86	25	the	the	DET
admet-2802	86	26	absence	absence	NOUN
admet-2802	86	27	of	of	ADP
admet-2802	86	28	bile	bile	NOUN
admet-2802	86	29	micelles	micelle	NOUN
admet-2802	86	30	(	(	PUNCT
admet-2802	86	31	1/2	1/2	NUM
admet-2802	86	32	of	of	ADP
admet-2802	86	33	the	the	DET
admet-2802	86	34	initial	initial	ADJ
admet-2802	86	35	donor	donor	NOUN
admet-2802	86	36	concentration	concentration	NOUN
admet-2802	86	37	)	)	PUNCT
admet-2802	86	38	.	.	PUNCT
admet-2802	87	1	the	the	DET
admet-2802	87	2	unbound	unbound	NOUN
admet-2802	87	3	fraction	fraction	NOUN
admet-2802	87	4	(	(	PUNCT
admet-2802	87	5	fu	fu	NOUN
admet-2802	87	6	)	)	PUNCT
admet-2802	87	7	was	be	AUX
admet-2802	87	8	calculated	calculate	VERB
admet-2802	87	9	as	as	ADP
admet-2802	87	10	the	the	DET
admet-2802	87	11	ratio	ratio	NOUN
admet-2802	87	12	of	of	ADP
admet-2802	87	13	permeation	permeation	NOUN
admet-2802	87	14	in	in	ADP
admet-2802	87	15	the	the	DET
admet-2802	87	16	presence	presence	NOUN
admet-2802	87	17	and	and	CCONJ
admet-2802	87	18	absence	absence	NOUN
admet-2802	87	19	of	of	ADP
admet-2802	87	20	bile	bile	NOUN
admet-2802	87	21	micelles	micelle	NOUN
admet-2802	87	22	.	.	PUNCT
admet-2802	88	1	kbm	kbm	PROPN
admet-2802	88	2	calculation	calculation	NOUN
admet-2802	88	3	the	the	DET
admet-2802	88	4	kbm	kbm	NOUN
admet-2802	88	5	value	value	NOUN
admet-2802	88	6	of	of	ADP
admet-2802	88	7	each	each	DET
admet-2802	88	8	charge	charge	NOUN
admet-2802	88	9	species	specie	NOUN
admet-2802	88	10	(	(	PUNCT
admet-2802	88	11	kbm	kbm	PROPN
admet-2802	88	12	,	,	PUNCT
admet-2802	88	13	z	z	NOUN
admet-2802	88	14	)	)	PUNCT
admet-2802	88	15	was	be	AUX
admet-2802	88	16	calculated	calculate	VERB
admet-2802	88	17	from	from	ADP
admet-2802	88	18	the	the	DET
admet-2802	88	19	ph	ph	VERB
admet-2802	88	20	-	-	PUNCT
admet-2802	88	21	fu	fu	NOUN
admet-2802	88	22	profile	profile	NOUN
admet-2802	89	1	[	[	X
admet-2802	89	2	27	27	NUM
admet-2802	89	3	]	]	PUNCT
admet-2802	89	4	.	.	PUNCT
admet-2802	90	1	for	for	ADP
admet-2802	90	2	monovalent	monovalent	NOUN
admet-2802	90	3	weak	weak	ADJ
admet-2802	90	4	acid	acid	NOUN
admet-2802	90	5	drugs	drug	NOUN
admet-2802	90	6	(	(	PUNCT
admet-2802	90	7	ha	ha	INTJ
admet-2802	90	8	)	)	PUNCT
admet-2802	90	9	,	,	PUNCT
admet-2802	90	10	the	the	DET
admet-2802	90	11	un	un	ADJ
admet-2802	90	12	-	-	ADJ
admet-2802	90	13	ionized	ionized	ADJ
admet-2802	90	14	fraction	fraction	NOUN
admet-2802	90	15	(	(	PUNCT
admet-2802	90	16	f0	f0	PROPN
admet-2802	90	17	)	)	PUNCT
admet-2802	90	18	is	be	AUX
admet-2802	90	19	defined	define	VERB
admet-2802	90	20	by	by	ADP
admet-2802	90	21	equation	equation	NOUN
admet-2802	90	22	(	(	PUNCT
admet-2802	90	23	1	1	NUM
admet-2802	90	24	)	)	PUNCT
admet-2802	90	25	,	,	PUNCT
admet-2802	90	26	0	0	NUM
admet-2802	91	1	-+	-+	PROPN
admet-2802	91	2	[	[	X
admet-2802	91	3	ha	ha	X
admet-2802	91	4	]	]	X
admet-2802	91	5	1	1	NUM
admet-2802	91	6	1	1	NUM
admet-2802	92	1	[	[	X
admet-2802	92	2	a	a	X
admet-2802	92	3	]	]	X
admet-2802	92	4	[	[	X
admet-2802	92	5	ha]+[a	ha]+[a	X
admet-2802	92	6	]	]	X
admet-2802	92	7	11	11	NUM
admet-2802	93	1	+	+	CCONJ
admet-2802	93	2	[	[	X
admet-2802	93	3	h	h	X
admet-2802	93	4	]	]	X
admet-2802	93	5	[	[	X
admet-2802	93	6	ha	ha	X
admet-2802	93	7	]	]	X
admet-2802	93	8	a	a	DET
admet-2802	93	9	f	f	X
admet-2802	93	10	k	k	PROPN
admet-2802	93	11	=	=	PUNCT
admet-2802	94	1	=	=	PUNCT
admet-2802	94	2	=	=	PUNCT
admet-2802	95	1	+	+	CCONJ
admet-2802	95	2	(	(	PUNCT
admet-2802	95	3	1	1	X
admet-2802	95	4	)	)	PUNCT
admet-2802	95	5	the	the	DET
admet-2802	95	6	unbound	unbound	NOUN
admet-2802	95	7	fraction	fraction	NOUN
admet-2802	95	8	(	(	PUNCT
admet-2802	95	9	fu	fu	NOUN
admet-2802	95	10	)	)	PUNCT
admet-2802	95	11	is	be	AUX
admet-2802	95	12	defined	define	VERB
admet-2802	95	13	by	by	ADP
admet-2802	95	14	equation	equation	NOUN
admet-2802	95	15	(	(	PUNCT
admet-2802	95	16	2	2	NUM
admet-2802	95	17	)	)	PUNCT
admet-2802	95	18	,	,	PUNCT
admet-2802	95	19	u	u	X
admet-2802	96	1	[	[	X
admet-2802	96	2	ha]+[a	ha]+[a	X
admet-2802	96	3	]	]	X
admet-2802	96	4	=	=	PUNCT
admet-2802	97	1	[	[	X
admet-2802	97	2	ha]+[a	ha]+[a	X
admet-2802	97	3	]	]	X
admet-2802	97	4	+	+	PROPN
admet-2802	97	5	[	[	X
admet-2802	97	6	ha	ha	INTJ
admet-2802	97	7	bm]+[a	bm]+[a	PROPN
admet-2802	97	8	bm	bm	PROPN
admet-2802	97	9	]	]	X
admet-2802	97	10	f	f	PROPN
admet-2802	97	11			PROPN
admet-2802	97	12			PROPN
admet-2802	97	13	(	(	PUNCT
admet-2802	97	14	2	2	NUM
admet-2802	97	15	)	)	PUNCT
admet-2802	97	16	therefore	therefore	ADV
admet-2802	97	17	,	,	PUNCT
admet-2802	97	18	the	the	DET
admet-2802	97	19	un	un	ADJ
admet-2802	97	20	-	-	ADJ
admet-2802	97	21	ionized	ionized	ADJ
admet-2802	97	22	unbound	unbound	NOUN
admet-2802	97	23	fraction	fraction	NOUN
admet-2802	97	24	(	(	PUNCT
admet-2802	97	25	f0fu	f0fu	PUNCT
admet-2802	97	26	)	)	PUNCT
admet-2802	97	27	becomes	become	VERB
admet-2802	97	28	,	,	PUNCT
admet-2802	97	29	equation	equation	NOUN
admet-2802	97	30	(	(	PUNCT
admet-2802	97	31	3	3	NUM
admet-2802	97	32	)	)	PUNCT
admet-2802	97	33	,	,	PUNCT
admet-2802	97	34	0	0	NUM
admet-2802	97	35	m	m	VERB
admet-2802	97	36	a	a	DET
admet-2802	97	37	bm,0	bm,0	PROPN
admet-2802	97	38	m,-1	m,-1	NUM
admet-2802	97	39	+	+	PROPN
admet-2802	97	40	+	+	NUM
admet-2802	97	41	w	w	NOUN
admet-2802	98	1	[	[	X
admet-2802	98	2	ha	ha	X
admet-2802	98	3	]	]	X
admet-2802	99	1	[	[	X
admet-2802	99	2	ha]+[a	ha]+[a	X
admet-2802	99	3	]	]	X
admet-2802	99	4	[	[	X
admet-2802	99	5	ha	ha	X
admet-2802	99	6	]	]	X
admet-2802	100	1	[	[	X
admet-2802	100	2	ha]+[a	ha]+[a	X
admet-2802	100	3	]	]	X
admet-2802	101	1	[	[	X
admet-2802	101	2	ha]+[a	ha]+[a	X
admet-2802	101	3	]	]	X
admet-2802	101	4	+	+	PROPN
admet-2802	101	5	[	[	X
admet-2802	101	6	ha	ha	INTJ
admet-2802	101	7	bm]+[a	bm]+[a	PROPN
admet-2802	101	8	bm	bm	PROPN
admet-2802	101	9	]	]	PUNCT
admet-2802	102	1	[	[	X
admet-2802	102	2	ha]+[a	ha]+[a	X
admet-2802	102	3	]	]	X
admet-2802	102	4	[	[	X
admet-2802	102	5	ha	ha	INTJ
admet-2802	102	6	bm]+[a	bm]+[a	PROPN
admet-2802	102	7	bm	bm	PROPN
admet-2802	102	8	]	]	X
admet-2802	102	9	1	1	NUM
admet-2802	102	10	1	1	NUM
admet-2802	103	1	[	[	X
admet-2802	103	2	a	a	X
admet-2802	103	3	]	]	X
admet-2802	104	1	[	[	X
admet-2802	104	2	ha	ha	X
admet-2802	104	3	bm	bm	X
admet-2802	104	4	]	]	X
admet-2802	105	1	[	[	X
admet-2802	105	2	a	a	X
admet-2802	105	3	]	]	X
admet-2802	105	4	[	[	X
admet-2802	105	5	a	a	DET
admet-2802	105	6	bm	bm	X
admet-2802	105	7	]	]	X
admet-2802	105	8	1	1	NUM
admet-2802	105	9	1	1	NUM
admet-2802	106	1	[	[	X
admet-2802	106	2	ha	ha	X
admet-2802	106	3	]	]	X
admet-2802	107	1	[	[	X
admet-2802	107	2	ha	ha	X
admet-2802	107	3	]	]	X
admet-2802	108	1	[	[	X
admet-2802	108	2	ha	ha	X
admet-2802	108	3	]	]	X
admet-2802	109	1	[	[	X
admet-2802	109	2	a	a	X
admet-2802	109	3	]	]	X
admet-2802	109	4	[	[	X
admet-2802	109	5	h	h	X
admet-2802	109	6	]	]	X
admet-2802	110	1	[	[	X
admet-2802	110	2	h	h	X
admet-2802	110	3	]	]	X
admet-2802	110	4	u	u	NOUN
admet-2802	110	5	a	a	PRON
admet-2802	110	6	b	b	PROPN
admet-2802	110	7	b	b	X
admet-2802	111	1	f	f	X
admet-2802	111	2	f	f	PROPN
admet-2802	112	1	k	k	PROPN
admet-2802	112	2	c	c	PROPN
admet-2802	112	3	k	k	PROPN
admet-2802	112	4	k	k	PROPN
admet-2802	112	5	k	k	PROPN
admet-2802	112	6	c	c	PROPN
admet-2802	112	7	=	=	PUNCT
admet-2802	112	8			NOUN
admet-2802	112	9	=	=	NOUN
admet-2802	112	10	=	=	PUNCT
admet-2802	113	1			PROPN
admet-2802	113	2			PROPN
admet-2802	113	3	+	+	CCONJ
admet-2802	113	4			PROPN
admet-2802	113	5			PROPN
admet-2802	113	6	=	=	SYM
admet-2802	113	7	=	=	PUNCT
admet-2802	113	8			ADJ
admet-2802	113	9			ADJ
admet-2802	113	10			NOUN
admet-2802	113	11			NOUN
admet-2802	113	12	+	+	X
admet-2802	114	1	+	+	PUNCT
admet-2802	115	1	+	+	PUNCT
admet-2802	115	2	+	+	PUNCT
admet-2802	115	3	+	+	CCONJ
admet-2802	115	4	+	+	ADJ
admet-2802	115	5			ADJ
admet-2802	115	6			CCONJ
admet-2802	116	1			PROPN
admet-2802	116	2			NOUN
admet-2802	116	3	(	(	PUNCT
admet-2802	116	4	3	3	NUM
admet-2802	116	5	)	)	PUNCT
admet-2802	116	6	where	where	SCONJ
admet-2802	116	7	bm	bm	PROPN
admet-2802	116	8	is	be	AUX
admet-2802	116	9	bile	bile	NOUN
admet-2802	116	10	micelles	micelle	NOUN
admet-2802	116	11	,	,	PUNCT
admet-2802	116	12	cbm	cbm	PROPN
admet-2802	116	13	is	be	AUX
admet-2802	116	14	the	the	DET
admet-2802	116	15	concentration	concentration	NOUN
admet-2802	116	16	of	of	ADP
admet-2802	116	17	bm	bm	PROPN
admet-2802	116	18	(	(	PUNCT
admet-2802	116	19	mol	mol	PROPN
admet-2802	116	20	/	/	SYM
admet-2802	116	21	l	l	NOUN
admet-2802	116	22	)	)	PUNCT
admet-2802	116	23	(	(	PUNCT
admet-2802	116	24	in	in	ADP
admet-2802	116	25	this	this	DET
admet-2802	116	26	study	study	NOUN
admet-2802	116	27	,	,	PUNCT
admet-2802	116	28	0.015	0.015	NUM
admet-2802	116	29	mol	mol	ADP
admet-2802	116	30	/	/	SYM
admet-2802	116	31	l	l	NOUN
admet-2802	116	32	)	)	PUNCT
admet-2802	116	33	,	,	PUNCT
admet-2802	116	34	and	and	CCONJ
admet-2802	116	35	cw	cw	NOUN
admet-2802	116	36	is	be	AUX
admet-2802	116	37	the	the	DET
admet-2802	116	38	concentration	concentration	NOUN
admet-2802	116	39	of	of	ADP
admet-2802	116	40	water	water	NOUN
admet-2802	116	41	(	(	PUNCT
admet-2802	116	42	55.5	55.5	NUM
admet-2802	116	43	mol	mol	ADP
admet-2802	116	44	l-1	l-1	NUM
admet-2802	116	45	)	)	PUNCT
admet-2802	117	1	[	[	X
admet-2802	117	2	11	11	NUM
admet-2802	117	3	]	]	PUNCT
admet-2802	117	4	.	.	PUNCT
admet-2802	118	1	the	the	DET
admet-2802	118	2	fu	fu	PROPN
admet-2802	118	3	value	value	NOUN
admet-2802	118	4	can	can	AUX
admet-2802	118	5	be	be	AUX
admet-2802	118	6	calculated	calculate	VERB
admet-2802	118	7	by	by	ADP
admet-2802	118	8	dividing	divide	VERB
admet-2802	118	9	eq	eq	ADP
admet-2802	118	10	.	.	PUNCT
admet-2802	119	1	(	(	PUNCT
admet-2802	119	2	3	3	X
admet-2802	119	3	)	)	PUNCT
admet-2802	119	4	by	by	ADP
admet-2802	119	5	eq	eq	PROPN
admet-2802	119	6	.	.	PUNCT
admet-2802	120	1	(	(	PUNCT
admet-2802	120	2	1	1	NUM
admet-2802	120	3	)	)	PUNCT
admet-2802	120	4	.	.	PUNCT
admet-2802	121	1	similarly	similarly	ADV
admet-2802	121	2	,	,	PUNCT
admet-2802	121	3	for	for	ADP
admet-2802	121	4	monovalent	monovalent	NOUN
admet-2802	121	5	weak	weak	ADJ
admet-2802	121	6	base	base	NOUN
admet-2802	121	7	drugs	drug	NOUN
admet-2802	121	8	(	(	PUNCT
admet-2802	121	9	b	b	NOUN
admet-2802	121	10	)	)	PUNCT
admet-2802	121	11	,	,	PUNCT
admet-2802	121	12	equations	equation	NOUN
admet-2802	121	13	(	(	PUNCT
admet-2802	121	14	4	4	NUM
admet-2802	121	15	)	)	PUNCT
admet-2802	121	16	and	and	CCONJ
admet-2802	121	17	(	(	PUNCT
admet-2802	121	18	5	5	NUM
admet-2802	121	19	)	)	PUNCT
admet-2802	121	20	0	0	PUNCT
admet-2802	122	1	+	+	CCONJ
admet-2802	123	1	+	+	PUNCT
admet-2802	123	2	+	+	NUM
admet-2802	123	3	a	a	DET
admet-2802	123	4	[	[	X
admet-2802	123	5	b	b	X
admet-2802	123	6	]	]	X
admet-2802	123	7	1	1	NUM
admet-2802	123	8	1	1	NUM
admet-2802	124	1	[	[	X
admet-2802	124	2	bh	bh	X
admet-2802	124	3	]	]	X
admet-2802	125	1	[	[	X
admet-2802	125	2	h	h	X
admet-2802	125	3	]	]	X
admet-2802	125	4	[	[	X
admet-2802	125	5	b	b	X
admet-2802	125	6	]	]	X
admet-2802	125	7	[	[	X
admet-2802	125	8	bh	bh	X
admet-2802	125	9	]	]	X
admet-2802	125	10	1	1	NUM
admet-2802	125	11	1	1	NUM
admet-2802	126	1	[	[	X
admet-2802	126	2	b	b	X
admet-2802	126	3	]	]	X
admet-2802	126	4	f	f	X
admet-2802	126	5	k	k	NOUN
admet-2802	127	1	=	=	PUNCT
admet-2802	127	2	=	=	PUNCT
admet-2802	127	3	=	=	PUNCT
admet-2802	128	1	+	+	PUNCT
admet-2802	128	2	+	+	PUNCT
admet-2802	128	3	+	+	CCONJ
admet-2802	128	4	(	(	PUNCT
admet-2802	128	5	4	4	NUM
admet-2802	128	6	)	)	PUNCT
admet-2802	128	7	0	0	NUM
admet-2802	128	8	u	u	NOUN
admet-2802	128	9	+	+	X
admet-2802	129	1	+	+	PUNCT
admet-2802	129	2	+	+	CCONJ
admet-2802	129	3	+	+	CCONJ
admet-2802	129	4	bm	bm	PROPN
admet-2802	129	5	bm,0	bm,0	PROPN
admet-2802	129	6	m,+1	m,+1	PROPN
admet-2802	129	7	a	a	DET
admet-2802	129	8	w	w	NOUN
admet-2802	129	9	a	a	DET
admet-2802	129	10	[	[	X
admet-2802	129	11	b	b	X
admet-2802	129	12	]	]	X
admet-2802	129	13	1	1	NUM
admet-2802	129	14	[	[	X
admet-2802	129	15	b	b	X
admet-2802	129	16	]	]	X
admet-2802	129	17	[	[	X
admet-2802	129	18	bh	bh	X
admet-2802	129	19	]	]	PUNCT
admet-2802	130	1	[	[	X
admet-2802	130	2	b	b	X
admet-2802	130	3	bm	bm	X
admet-2802	130	4	]	]	X
admet-2802	131	1	[	[	X
admet-2802	131	2	bh	bh	X
admet-2802	131	3	bm	bm	PROPN
admet-2802	131	4	]	]	X
admet-2802	132	1	[	[	X
admet-2802	132	2	h	h	X
admet-2802	132	3	]	]	X
admet-2802	133	1	[	[	X
admet-2802	133	2	h	h	X
admet-2802	133	3	]	]	X
admet-2802	133	4	1	1	NUM
admet-2802	133	5	+	+	SYM
admet-2802	133	6	b	b	X
admet-2802	133	7	f	f	X
admet-2802	134	1	f	f	PROPN
admet-2802	134	2	c	c	PROPN
admet-2802	135	1	k	k	PROPN
admet-2802	135	2	k	k	PROPN
admet-2802	136	1	k	k	PROPN
admet-2802	136	2	c	c	X
admet-2802	136	3	k	k	NOUN
admet-2802	137	1	=	=	PUNCT
admet-2802	137	2	=	=	PUNCT
admet-2802	138	1	+	+	PUNCT
admet-2802	138	2	+	+	CCONJ
admet-2802	138	3			ADJ
admet-2802	138	4	+	+	CCONJ
admet-2802	138	5			ADJ
admet-2802	138	6			NOUN
admet-2802	138	7			NOUN
admet-2802	138	8	+	+	CCONJ
admet-2802	138	9	+	+	CCONJ
admet-2802	138	10			PROPN
admet-2802	138	11			PROPN
admet-2802	138	12			PROPN
admet-2802	138	13			NOUN
admet-2802	138	14	(	(	PUNCT
admet-2802	138	15	5	5	NUM
admet-2802	138	16	)	)	PUNCT
admet-2802	138	17	for	for	ADP
admet-2802	138	18	divalent	divalent	ADJ
admet-2802	138	19	weak	weak	ADJ
admet-2802	138	20	base	base	NOUN
admet-2802	138	21	drugs	drug	NOUN
admet-2802	138	22	with	with	ADP
admet-2802	138	23	pka1	pka1	NOUN
admet-2802	138	24	and	and	CCONJ
admet-2802	138	25	pka2	pka2	PROPN
admet-2802	138	26	(	(	PUNCT
admet-2802	138	27	b	b	NOUN
admet-2802	138	28	)	)	PUNCT
admet-2802	138	29	(	(	PUNCT
admet-2802	138	30	pka1	pka1	PROPN
admet-2802	138	31	<	<	X
admet-2802	138	32	pka2	pka2	PROPN
admet-2802	138	33	)	)	PUNCT
admet-2802	138	34	,	,	PUNCT
admet-2802	138	35	equations	equation	NOUN
admet-2802	138	36	(	(	PUNCT
admet-2802	138	37	6	6	NUM
admet-2802	138	38	)	)	PUNCT
admet-2802	138	39	and	and	CCONJ
admet-2802	138	40	(	(	PUNCT
admet-2802	138	41	7	7	NUM
admet-2802	138	42	)	)	PUNCT
admet-2802	138	43	,	,	PUNCT
admet-2802	138	44	0	0	NUM
admet-2802	139	1	+	+	CCONJ
admet-2802	140	1	+	+	CCONJ
admet-2802	140	2	2	2	NUM
admet-2802	140	3	+	+	ADJ
admet-2802	140	4	+	+	ADJ
admet-2802	140	5	+	+	ADJ
admet-2802	140	6	+	+	ADJ
admet-2802	140	7	+	+	NUM
admet-2802	140	8	22	22	NUM
admet-2802	140	9	+	+	CCONJ
admet-2802	140	10	a1	a1	NOUN
admet-2802	140	11	a2	a2	PROPN
admet-2802	140	12	a2	a2	PROPN
admet-2802	140	13	[	[	X
admet-2802	140	14	b	b	X
admet-2802	140	15	]	]	X
admet-2802	140	16	1	1	NUM
admet-2802	140	17	1	1	NUM
admet-2802	141	1	[	[	X
admet-2802	141	2	bh	bh	X
admet-2802	141	3	]	]	PUNCT
admet-2802	142	1	[	[	X
admet-2802	142	2	h	h	X
admet-2802	142	3	]	]	X
admet-2802	143	1	[	[	X
admet-2802	143	2	h	h	X
admet-2802	143	3	]	]	X
admet-2802	144	1	[	[	X
admet-2802	144	2	bh	bh	X
admet-2802	144	3	]	]	PUNCT
admet-2802	145	1	[	[	X
admet-2802	145	2	bh	bh	X
admet-2802	145	3	]	]	X
admet-2802	145	4	[	[	X
admet-2802	145	5	bh	bh	X
admet-2802	145	6	]	]	PUNCT
admet-2802	146	1	[	[	X
admet-2802	146	2	bh	bh	X
admet-2802	146	3	]	]	PUNCT
admet-2802	147	1	[	[	X
admet-2802	147	2	b	b	X
admet-2802	147	3	]	]	PUNCT
admet-2802	147	4	11	11	NUM
admet-2802	148	1	[	[	X
admet-2802	148	2	bh	bh	X
admet-2802	148	3	]	]	PUNCT
admet-2802	149	1	[	[	X
admet-2802	149	2	b	b	X
admet-2802	149	3	]	]	X
admet-2802	150	1	[	[	X
admet-2802	150	2	b	b	X
admet-2802	150	3	]	]	X
admet-2802	150	4	f	f	PROPN
admet-2802	151	1	k	k	PROPN
admet-2802	151	2	k	k	PROPN
admet-2802	151	3	k	k	PROPN
admet-2802	151	4	=	=	PUNCT
admet-2802	152	1	=	=	PUNCT
admet-2802	152	2	=	=	PUNCT
admet-2802	153	1	+	+	PUNCT
admet-2802	153	2	+	+	PUNCT
admet-2802	153	3	+	+	PUNCT
admet-2802	154	1	+	+	ADJ
admet-2802	154	2	+	+	ADJ
admet-2802	154	3	+	+	CCONJ
admet-2802	154	4	(	(	PUNCT
admet-2802	154	5	6	6	NUM
admet-2802	154	6	)	)	PUNCT
admet-2802	154	7	0	0	NUM
admet-2802	155	1	u	u	NOUN
admet-2802	155	2	+	+	X
admet-2802	156	1	+	+	CCONJ
admet-2802	156	2	2	2	NUM
admet-2802	156	3	2	2	NUM
admet-2802	156	4	2	2	NUM
admet-2802	156	5	2	2	NUM
admet-2802	156	6	+	+	CCONJ
admet-2802	156	7	2	2	NUM
admet-2802	156	8	+	+	CCONJ
admet-2802	156	9	+	+	NUM
admet-2802	156	10	2	2	NUM
admet-2802	156	11	+	+	NUM
admet-2802	156	12	bm	bm	PROPN
admet-2802	156	13	bm,+2	bm,+2	VERB
admet-2802	156	14	bm,+1	bm,+1	PROPN
admet-2802	156	15	bm,0	bm,0	PROPN
admet-2802	156	16	a1	a1	NOUN
admet-2802	156	17	a2	a2	PROPN
admet-2802	156	18	a2	a2	PROPN
admet-2802	156	19	w	w	PROPN
admet-2802	156	20	a1	a1	PROPN
admet-2802	156	21	a2	a2	PROPN
admet-2802	156	22	a2	a2	PROPN
admet-2802	157	1	[	[	X
admet-2802	157	2	b	b	X
admet-2802	157	3	]	]	X
admet-2802	157	4	[	[	X
admet-2802	157	5	bh	bh	X
admet-2802	157	6	]	]	PUNCT
admet-2802	158	1	[	[	X
admet-2802	158	2	bh	bh	X
admet-2802	158	3	]	]	PUNCT
admet-2802	159	1	[	[	X
admet-2802	159	2	b	b	X
admet-2802	159	3	]	]	X
admet-2802	159	4	[	[	X
admet-2802	159	5	bh	bh	X
admet-2802	159	6	bm	bm	PROPN
admet-2802	159	7	]	]	X
admet-2802	160	1	[	[	X
admet-2802	160	2	bh	bh	X
admet-2802	160	3	bm	bm	PROPN
admet-2802	160	4	]	]	X
admet-2802	161	1	[	[	X
admet-2802	161	2	b	b	X
admet-2802	161	3	bm	bm	X
admet-2802	161	4	]	]	X
admet-2802	161	5	1	1	NUM
admet-2802	161	6	[	[	X
admet-2802	161	7	h	h	X
admet-2802	161	8	]	]	X
admet-2802	162	1	[	[	X
admet-2802	162	2	b	b	X
admet-2802	162	3	]	]	X
admet-2802	163	1	[	[	X
admet-2802	163	2	h	h	X
admet-2802	163	3	]	]	X
admet-2802	164	1	[	[	X
admet-2802	164	2	h	h	X
admet-2802	164	3	]	]	X
admet-2802	164	4	1	1	NUM
admet-2802	165	1	+	+	SYM
admet-2802	165	2	+	+	CCONJ
admet-2802	165	3	k	k	PROPN
admet-2802	165	4	f	f	PROPN
admet-2802	166	1	f	f	PROPN
admet-2802	166	2	c	c	PROPN
admet-2802	167	1	k	k	PROPN
admet-2802	167	2	k	k	PROPN
admet-2802	168	1	k	k	PROPN
admet-2802	168	2	k	k	PROPN
admet-2802	169	1	k	k	PROPN
admet-2802	170	1	k	k	PROPN
admet-2802	170	2	c	c	X
admet-2802	171	1	k	k	PROPN
admet-2802	171	2	k	k	PROPN
admet-2802	172	1	=	=	PUNCT
admet-2802	173	1	=	=	PUNCT
admet-2802	174	1	+	+	PUNCT
admet-2802	174	2	+	+	CCONJ
admet-2802	174	3	+	+	CCONJ
admet-2802	174	4			ADJ
admet-2802	174	5	+	+	CCONJ
admet-2802	174	6			ADJ
admet-2802	174	7	+	+	CCONJ
admet-2802	174	8			ADJ
admet-2802	174	9	=	=	SYM
admet-2802	174	10			NOUN
admet-2802	174	11			NOUN
admet-2802	174	12	+	+	X
admet-2802	175	1	+	+	PUNCT
admet-2802	175	2	+	+	CCONJ
admet-2802	175	3			ADJ
admet-2802	175	4			PROPN
admet-2802	175	5			PROPN
admet-2802	175	6			NOUN
admet-2802	175	7	(	(	PUNCT
admet-2802	175	8	7	7	NUM
admet-2802	175	9	)	)	PUNCT
admet-2802	175	10	for	for	ADP
admet-2802	175	11	zwitterion	zwitterion	NOUN
admet-2802	175	12	drugs	drug	NOUN
admet-2802	175	13	with	with	ADP
admet-2802	175	14	pka1	pka1	NOUN
admet-2802	175	15	and	and	CCONJ
admet-2802	175	16	pka2	pka2	NOUN
admet-2802	175	17	(	(	PUNCT
admet-2802	175	18	d	d	NOUN
admet-2802	175	19	)	)	PUNCT
admet-2802	175	20	(	(	PUNCT
admet-2802	175	21	pka1	pka1	PROPN
admet-2802	175	22	<	<	X
admet-2802	175	23	pka2	pka2	PROPN
admet-2802	175	24	)	)	PUNCT
admet-2802	175	25	,	,	PUNCT
admet-2802	175	26	equations	equation	NOUN
admet-2802	175	27	(	(	PUNCT
admet-2802	175	28	8)	8)	NUM
admet-2802	175	29	and	and	CCONJ
admet-2802	175	30	(	(	PUNCT
admet-2802	175	31	9	9	NUM
admet-2802	175	32	)	)	PUNCT
admet-2802	175	33	,	,	PUNCT
admet-2802	175	34	admet	admet	PROPN
admet-2802	175	35	&	&	CCONJ
admet-2802	175	36	dmpk	dmpk	PROPN
admet-2802	175	37	13(4	13(4	NUM
admet-2802	175	38	)	)	PUNCT
admet-2802	175	39	(	(	PUNCT
admet-2802	175	40	2025	2025	NUM
admet-2802	175	41	)	)	PUNCT
admet-2802	175	42	2802	2802	NUM
admet-2802	175	43	bile	bile	NOUN
admet-2802	175	44	micelle	micelle	NOUN
admet-2802	175	45	binding	bind	VERB
admet-2802	175	46	of	of	ADP
admet-2802	175	47	structurally	structurally	ADV
admet-2802	175	48	diverse	diverse	ADJ
admet-2802	175	49	ionized	ionized	ADJ
admet-2802	175	50	drugs	drug	NOUN
admet-2802	175	51	doi	doi	NOUN
admet-2802	175	52	:	:	PUNCT
admet-2802	175	53	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	175	54	5	5	NUM
admet-2802	175	55	0	0	NUM
admet-2802	176	1	+	+	CCONJ
admet-2802	176	2	+	+	ADJ
admet-2802	176	3	+	+	NUM
admet-2802	176	4	a2	a2	NOUN
admet-2802	176	5	+	+	CCONJ
admet-2802	176	6	a1	a1	NOUN
admet-2802	176	7	[	[	X
admet-2802	176	8	d	d	X
admet-2802	176	9	]	]	X
admet-2802	176	10	1	1	NUM
admet-2802	176	11	1	1	NUM
admet-2802	177	1	[	[	X
admet-2802	177	2	dh	dh	X
admet-2802	177	3	]	]	PUNCT
admet-2802	178	1	[	[	X
admet-2802	178	2	d	d	X
admet-2802	178	3	]	]	X
admet-2802	179	1	[	[	X
admet-2802	179	2	h	h	X
admet-2802	179	3	]	]	X
admet-2802	180	1	[	[	X
admet-2802	180	2	dh	dh	X
admet-2802	180	3	]	]	PUNCT
admet-2802	181	1	[	[	X
admet-2802	181	2	d	d	X
admet-2802	181	3	]	]	X
admet-2802	182	1	[	[	X
admet-2802	182	2	d	d	X
admet-2802	182	3	]	]	X
admet-2802	182	4	1	1	NUM
admet-2802	182	5	1	1	NUM
admet-2802	182	6	[	[	X
admet-2802	182	7	d	d	X
admet-2802	182	8	]	]	X
admet-2802	183	1	[	[	X
admet-2802	183	2	d	d	X
admet-2802	183	3	]	]	X
admet-2802	184	1	[	[	X
admet-2802	184	2	h	h	X
admet-2802	184	3	]	]	X
admet-2802	184	4	f	f	X
admet-2802	185	1	k	k	PROPN
admet-2802	185	2	k	k	PROPN
admet-2802	186	1	=	=	PUNCT
admet-2802	186	2	=	=	PUNCT
admet-2802	187	1	=	=	PUNCT
admet-2802	188	1	+	+	PUNCT
admet-2802	189	1	+	+	PUNCT
admet-2802	189	2	+	+	PUNCT
admet-2802	189	3	+	+	PUNCT
admet-2802	189	4	+	+	PUNCT
admet-2802	189	5	+	+	CCONJ
admet-2802	189	6	(	(	PUNCT
admet-2802	189	7	8)	8)	NUM
admet-2802	189	8	0	0	NUM
admet-2802	189	9	u	u	NOUN
admet-2802	189	10	+	+	X
admet-2802	190	1	+	+	PUNCT
admet-2802	190	2	+	+	CCONJ
admet-2802	190	3	+	+	NUM
admet-2802	190	4	a2	a2	PROPN
admet-2802	190	5	bm	bm	PROPN
admet-2802	190	6	a2	a2	PROPN
admet-2802	190	7	bm,+1	bm,+1	PROPN
admet-2802	190	8	bm,0	bm,0	PROPN
admet-2802	191	1	m,-1	m,-1	NUM
admet-2802	191	2	+	+	NOUN
admet-2802	191	3	+	+	CCONJ
admet-2802	191	4	a1	a1	NOUN
admet-2802	191	5	w	w	PROPN
admet-2802	191	6	a1	a1	NOUN
admet-2802	192	1	[	[	X
admet-2802	192	2	d	d	X
admet-2802	192	3	]	]	X
admet-2802	193	1	[	[	X
admet-2802	193	2	dh	dh	X
admet-2802	193	3	]	]	PUNCT
admet-2802	194	1	[	[	X
admet-2802	194	2	d	d	X
admet-2802	194	3	]	]	X
admet-2802	195	1	[	[	X
admet-2802	195	2	d	d	X
admet-2802	195	3	]	]	X
admet-2802	196	1	[	[	X
admet-2802	196	2	dh	dh	NOUN
admet-2802	196	3	bm	bm	X
admet-2802	196	4	]	]	PUNCT
admet-2802	197	1	[	[	X
admet-2802	197	2	d	d	X
admet-2802	197	3	bm	bm	X
admet-2802	197	4	]	]	X
admet-2802	198	1	[	[	X
admet-2802	198	2	d	d	X
admet-2802	198	3	bm	bm	X
admet-2802	198	4	]	]	PUNCT
admet-2802	198	5	1	1	NUM
admet-2802	199	1	[	[	X
admet-2802	199	2	h	h	X
admet-2802	199	3	]	]	X
admet-2802	200	1	[	[	X
admet-2802	200	2	h	h	X
admet-2802	200	3	]	]	X
admet-2802	200	4	1	1	NUM
admet-2802	201	1	+	+	SYM
admet-2802	201	2	+	+	CCONJ
admet-2802	202	1	[	[	X
admet-2802	202	2	h	h	X
admet-2802	202	3	]	]	X
admet-2802	203	1	[	[	X
admet-2802	203	2	h	h	X
admet-2802	203	3	]	]	X
admet-2802	203	4	b	b	X
admet-2802	204	1	f	f	X
admet-2802	204	2	f	f	X
admet-2802	205	1	k	k	PROPN
admet-2802	205	2	c	c	PROPN
admet-2802	206	1	k	k	PROPN
admet-2802	206	2	k	k	PROPN
admet-2802	207	1	k	k	PROPN
admet-2802	207	2	k	k	PROPN
admet-2802	208	1	k	k	PROPN
admet-2802	208	2	c	c	X
admet-2802	208	3	k	k	NOUN
admet-2802	209	1	−	−	PROPN
admet-2802	210	1	=	=	PUNCT
admet-2802	210	2	=	=	PUNCT
admet-2802	211	1	+	+	PUNCT
admet-2802	211	2	+	+	CCONJ
admet-2802	211	3	+	+	CCONJ
admet-2802	211	4			ADJ
admet-2802	211	5	+	+	CCONJ
admet-2802	211	6			ADJ
admet-2802	211	7	+	+	CCONJ
admet-2802	211	8			ADJ
admet-2802	211	9	=	=	SYM
admet-2802	211	10			NOUN
admet-2802	211	11			NOUN
admet-2802	211	12	+	+	X
admet-2802	212	1	+	+	PUNCT
admet-2802	212	2	+	+	CCONJ
admet-2802	212	3			ADJ
admet-2802	212	4			PROPN
admet-2802	212	5			PROPN
admet-2802	212	6			NOUN
admet-2802	212	7	(	(	PUNCT
admet-2802	212	8	9	9	NUM
admet-2802	212	9	)	)	PUNCT
admet-2802	212	10	the	the	DET
admet-2802	212	11	kbm	kbm	NOUN
admet-2802	212	12	,	,	PUNCT
admet-2802	212	13	z	z	NOUN
admet-2802	212	14	values	value	NOUN
admet-2802	212	15	can	can	AUX
admet-2802	212	16	be	be	AUX
admet-2802	212	17	obtained	obtain	VERB
admet-2802	212	18	by	by	ADP
admet-2802	212	19	fitting	fit	VERB
admet-2802	212	20	the	the	DET
admet-2802	212	21	theoretical	theoretical	ADJ
admet-2802	212	22	ph	ph	ADJ
admet-2802	212	23	-	-	PUNCT
admet-2802	212	24	fu	fu	NOUN
admet-2802	212	25	curve	curve	NOUN
admet-2802	212	26	to	to	PART
admet-2802	212	27	experimentally	experimentally	ADV
admet-2802	212	28	observed	observe	VERB
admet-2802	212	29	data	datum	NOUN
admet-2802	212	30	by	by	ADP
admet-2802	212	31	the	the	DET
admet-2802	212	32	least	least	ADJ
admet-2802	212	33	squares	square	NOUN
admet-2802	212	34	method	method	NOUN
admet-2802	212	35	using	use	VERB
admet-2802	212	36	the	the	DET
admet-2802	212	37	excel	excel	NOUN
admet-2802	212	38	solver	solver	NOUN
admet-2802	212	39	.	.	PUNCT
admet-2802	213	1	because	because	SCONJ
admet-2802	213	2	the	the	DET
admet-2802	213	3	fu	fu	NOUN
admet-2802	213	4	was	be	AUX
admet-2802	213	5	measured	measure	VERB
admet-2802	213	6	at	at	ADP
admet-2802	213	7	37	37	NUM
admet-2802	213	8	°	°	NOUN
admet-2802	213	9	c	c	NOUN
admet-2802	213	10	,	,	PUNCT
admet-2802	213	11	the	the	DET
admet-2802	213	12	pka	pka	PROPN
admet-2802	213	13	value	value	NOUN
admet-2802	213	14	at	at	ADP
admet-2802	213	15	37	37	NUM
admet-2802	213	16	°	°	NOUN
admet-2802	213	17	c	c	X
admet-2802	213	18	(	(	PUNCT
admet-2802	213	19	pka(37	pka(37	PROPN
admet-2802	213	20	°	°	NOUN
admet-2802	213	21	c	c	NOUN
admet-2802	213	22	)	)	PUNCT
admet-2802	213	23	)	)	PUNCT
admet-2802	213	24	was	be	AUX
admet-2802	213	25	used	use	VERB
admet-2802	213	26	for	for	ADP
admet-2802	213	27	the	the	DET
admet-2802	213	28	calculation	calculation	NOUN
admet-2802	213	29	when	when	SCONJ
admet-2802	213	30	available	available	ADJ
admet-2802	213	31	in	in	ADP
admet-2802	213	32	the	the	DET
admet-2802	213	33	literature	literature	NOUN
admet-2802	213	34	.	.	PUNCT
admet-2802	214	1	the	the	DET
admet-2802	214	2	pka	pka	PROPN
admet-2802	214	3	value	value	NOUN
admet-2802	214	4	at	at	ADP
admet-2802	214	5	25	25	NUM
admet-2802	214	6	°	°	NOUN
admet-2802	214	7	c	c	NOUN
admet-2802	214	8	can	can	AUX
admet-2802	214	9	be	be	AUX
admet-2802	214	10	converted	convert	VERB
admet-2802	214	11	to	to	ADP
admet-2802	214	12	pka(37	pka(37	PROPN
admet-2802	214	13	°	°	NOUN
admet-2802	214	14	c	c	NOUN
admet-2802	214	15	)	)	PUNCT
admet-2802	214	16	by	by	ADP
admet-2802	214	17	the	the	DET
admet-2802	214	18	abraham	abraham	PROPN
admet-2802	214	19	linear	linear	PROPN
admet-2802	214	20	free	free	ADJ
admet-2802	214	21	energy	energy	NOUN
admet-2802	214	22	relationship	relationship	NOUN
admet-2802	214	23	[	[	X
admet-2802	214	24	28	28	NUM
admet-2802	214	25	]	]	PUNCT
admet-2802	214	26	.	.	PUNCT
admet-2802	215	1	however	however	ADV
admet-2802	215	2	,	,	PUNCT
admet-2802	215	3	the	the	DET
admet-2802	215	4	abraham	abraham	PROPN
admet-2802	215	5	solute	solute	PROPN
admet-2802	215	6	descriptor	descriptor	NOUN
admet-2802	215	7	was	be	AUX
admet-2802	215	8	not	not	PART
admet-2802	215	9	available	available	ADJ
admet-2802	215	10	for	for	ADP
admet-2802	215	11	some	some	DET
admet-2802	215	12	drugs	drug	NOUN
admet-2802	215	13	.	.	PUNCT
admet-2802	216	1	in	in	ADP
admet-2802	216	2	addition	addition	NOUN
admet-2802	216	3	,	,	PUNCT
admet-2802	216	4	the	the	DET
admet-2802	216	5	temperature	temperature	NOUN
admet-2802	216	6	was	be	AUX
admet-2802	216	7	not	not	PART
admet-2802	216	8	reported	report	VERB
admet-2802	216	9	.	.	PUNCT
admet-2802	217	1	therefore	therefore	ADV
admet-2802	217	2	,	,	PUNCT
admet-2802	217	3	in	in	ADP
admet-2802	217	4	these	these	DET
admet-2802	217	5	cases	case	NOUN
admet-2802	217	6	,	,	PUNCT
admet-2802	217	7	the	the	DET
admet-2802	217	8	reported	report	VERB
admet-2802	217	9	values	value	NOUN
admet-2802	217	10	were	be	AUX
admet-2802	217	11	used	use	VERB
admet-2802	217	12	as	as	SCONJ
admet-2802	217	13	it	it	PRON
admet-2802	217	14	is	be	AUX
admet-2802	217	15	.	.	PUNCT
admet-2802	218	1	[	[	X
admet-2802	218	2	h+	h+	AUX
admet-2802	218	3	]	]	X
admet-2802	218	4	was	be	AUX
admet-2802	218	5	calculated	calculate	VERB
admet-2802	218	6	as	as	ADP
admet-2802	218	7	10	10	NUM
admet-2802	218	8	-	-	PUNCT
admet-2802	218	9	ph	ph	ADJ
admet-2802	218	10	,	,	PUNCT
admet-2802	218	11	neglecting	neglect	VERB
admet-2802	218	12	the	the	DET
admet-2802	218	13	effect	effect	NOUN
admet-2802	218	14	of	of	ADP
admet-2802	218	15	ionic	ionic	ADJ
admet-2802	218	16	strength	strength	NOUN
admet-2802	218	17	(	(	PUNCT
admet-2802	218	18	i	i	NOUN
admet-2802	218	19	)	)	PUNCT
admet-2802	218	20	(	(	PUNCT
admet-2802	218	21	about	about	ADV
admet-2802	218	22	0.1	0.1	NUM
admet-2802	218	23	ph	ph	NOUN
admet-2802	218	24	unit	unit	NOUN
admet-2802	218	25	)	)	PUNCT
admet-2802	218	26	and	and	CCONJ
admet-2802	218	27	the	the	DET
admet-2802	218	28	electrode	electrode	NOUN
admet-2802	218	29	factors	factor	NOUN
admet-2802	218	30	[	[	X
admet-2802	218	31	12	12	NUM
admet-2802	218	32	]	]	PUNCT
admet-2802	218	33	.	.	PUNCT
admet-2802	219	1	results	result	NOUN
admet-2802	219	2	and	and	CCONJ
admet-2802	219	3	discussion	discussion	NOUN
admet-2802	219	4	permeation	permeation	NOUN
admet-2802	219	5	and	and	CCONJ
admet-2802	219	6	fu	fu	NOUN
admet-2802	219	7	values	value	NOUN
admet-2802	219	8	at	at	ADP
admet-2802	219	9	each	each	DET
admet-2802	219	10	ph	ph	NOUN
admet-2802	219	11	are	be	AUX
admet-2802	219	12	summarized	summarize	VERB
admet-2802	219	13	in	in	ADP
admet-2802	219	14	sm	sm	PROPN
admet-2802	219	15	table	table	NOUN
admet-2802	219	16	s1	s1	PROPN
admet-2802	219	17	.	.	PUNCT
admet-2802	220	1	since	since	SCONJ
admet-2802	220	2	the	the	DET
admet-2802	220	3	fu	fu	NOUN
admet-2802	220	4	value	value	NOUN
admet-2802	220	5	becomes	become	VERB
admet-2802	220	6	sensitive	sensitive	ADJ
admet-2802	220	7	to	to	ADP
admet-2802	220	8	the	the	DET
admet-2802	220	9	variation	variation	NOUN
admet-2802	220	10	in	in	ADP
admet-2802	220	11	permeation	permeation	NOUN
admet-2802	220	12	at	at	ADP
admet-2802	220	13	fu	fu	PROPN
admet-2802	220	14	>	>	X
admet-2802	220	15	0.9	0.9	NUM
admet-2802	220	16	,	,	PUNCT
admet-2802	220	17	they	they	PRON
admet-2802	220	18	were	be	AUX
admet-2802	220	19	not	not	PART
admet-2802	220	20	used	use	VERB
admet-2802	220	21	for	for	ADP
admet-2802	220	22	the	the	DET
admet-2802	220	23	following	follow	VERB
admet-2802	220	24	data	datum	NOUN
admet-2802	220	25	analysis	analysis	NOUN
admet-2802	220	26	.	.	PUNCT
admet-2802	221	1	monovalent	monovalent	NOUN
admet-2802	221	2	weak	weak	ADJ
admet-2802	221	3	acid	acid	NOUN
admet-2802	221	4	drugs	drug	NOUN
admet-2802	221	5	figure	figure	NOUN
admet-2802	221	6	2	2	NUM
admet-2802	221	7	shows	show	VERB
admet-2802	221	8	the	the	DET
admet-2802	221	9	ph	ph	VERB
admet-2802	221	10	-	-	PUNCT
admet-2802	221	11	fu	fu	ADJ
admet-2802	221	12	profiles	profile	NOUN
admet-2802	221	13	of	of	ADP
admet-2802	221	14	monovalent	monovalent	NOUN
admet-2802	221	15	weak	weak	ADJ
admet-2802	221	16	acid	acid	NOUN
admet-2802	221	17	drugs	drug	NOUN
admet-2802	221	18	.	.	PUNCT
admet-2802	222	1	the	the	DET
admet-2802	222	2	theoretical	theoretical	ADJ
admet-2802	222	3	equations	equation	NOUN
admet-2802	222	4	(	(	PUNCT
admet-2802	222	5	eqs	eqs	X
admet-2802	222	6	.	.	PUNCT
admet-2802	222	7	(	(	PUNCT
admet-2802	222	8	1	1	X
admet-2802	222	9	)	)	PUNCT
admet-2802	222	10	to	to	ADP
admet-2802	222	11	(	(	PUNCT
admet-2802	222	12	3	3	NUM
admet-2802	222	13	)	)	PUNCT
admet-2802	222	14	)	)	PUNCT
admet-2802	222	15	appropriately	appropriately	ADV
admet-2802	222	16	described	describe	VERB
admet-2802	222	17	the	the	DET
admet-2802	222	18	ph	ph	VERB
admet-2802	222	19	-	-	PUNCT
admet-2802	222	20	fu	fu	NOUN
admet-2802	222	21	profiles	profile	NOUN
admet-2802	222	22	.	.	PUNCT
admet-2802	223	1	the	the	DET
admet-2802	223	2	kbm	kbm	NOUN
admet-2802	223	3	,	,	PUNCT
admet-2802	223	4	z	z	NOUN
admet-2802	223	5	values	value	NOUN
admet-2802	223	6	are	be	AUX
admet-2802	223	7	summarized	summarize	VERB
admet-2802	223	8	in	in	ADP
admet-2802	223	9	table	table	NOUN
admet-2802	223	10	2	2	NUM
admet-2802	223	11	.	.	PUNCT
admet-2802	223	12	figure	figure	NOUN
admet-2802	223	13	2	2	NUM
admet-2802	223	14	.	.	PUNCT
admet-2802	223	15	ph	ph	ADJ
admet-2802	223	16	-	-	PUNCT
admet-2802	223	17	fu	fu	NOUN
admet-2802	223	18	profile	profile	NOUN
admet-2802	223	19	of	of	ADP
admet-2802	223	20	monovalent	monovalent	NOUN
admet-2802	223	21	weak	weak	ADJ
admet-2802	223	22	acids	acid	NOUN
admet-2802	223	23	in	in	ADP
admet-2802	223	24	the	the	DET
admet-2802	223	25	tc	tc	PROPN
admet-2802	223	26	/	/	SYM
admet-2802	223	27	el	el	PROPN
admet-2802	223	28	bile	bile	NOUN
admet-2802	223	29	micelle	micelle	NOUN
admet-2802	223	30	media	medium	NOUN
admet-2802	223	31	(	(	PUNCT
admet-2802	223	32	mean	mean	PROPN
admet-2802	223	33	±	±	NUM
admet-2802	223	34	standard	standard	ADJ
admet-2802	223	35	deviation	deviation	NOUN
admet-2802	223	36	(	(	PUNCT
admet-2802	223	37	sd	sd	NOUN
admet-2802	223	38	)	)	PUNCT
admet-2802	223	39	,	,	PUNCT
admet-2802	223	40	n	n	NOUN
admet-2802	223	41	=	=	SYM
admet-2802	223	42	3	3	NUM
admet-2802	223	43	)	)	PUNCT
admet-2802	223	44	.	.	PUNCT
admet-2802	224	1	the	the	DET
admet-2802	224	2	solid	solid	ADJ
admet-2802	224	3	line	line	NOUN
admet-2802	224	4	is	be	AUX
admet-2802	224	5	the	the	DET
admet-2802	224	6	fitted	fit	VERB
admet-2802	224	7	theoretical	theoretical	ADJ
admet-2802	224	8	curve	curve	NOUN
admet-2802	224	9	f	f	PROPN
admet-2802	224	10	u	u	NOUN
admet-2802	224	11	f	f	PROPN
admet-2802	224	12	u	u	X
admet-2802	224	13	f	f	PROPN
admet-2802	224	14	u	u	X
admet-2802	224	15	f	f	PROPN
admet-2802	224	16	u	u	PROPN
admet-2802	224	17	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	PROPN
admet-2802	224	18	m.	m.	NOUN
admet-2802	224	19	konishi	konishi	PROPN
admet-2802	224	20	and	and	CCONJ
admet-2802	224	21	k.	k.	PROPN
admet-2802	224	22	sugano	sugano	PROPN
admet-2802	224	23	admet	admet	PROPN
admet-2802	224	24	&	&	CCONJ
admet-2802	224	25	dmpk	dmpk	PROPN
admet-2802	224	26	13(4	13(4	NUM
admet-2802	224	27	)	)	PUNCT
admet-2802	224	28	(	(	PUNCT
admet-2802	224	29	2025	2025	NUM
admet-2802	224	30	)	)	PUNCT
admet-2802	224	31	2802	2802	NUM
admet-2802	224	32	6	6	NUM
admet-2802	224	33	table	table	NOUN
admet-2802	224	34	2	2	NUM
admet-2802	224	35	.	.	PUNCT
admet-2802	225	1	kbm	kbm	NOUN
admet-2802	225	2	values	value	NOUN
admet-2802	225	3	of	of	ADP
admet-2802	225	4	monovalent	monovalent	NOUN
admet-2802	225	5	weak	weak	ADJ
admet-2802	225	6	acid	acid	NOUN
admet-2802	225	7	drugs	drug	NOUN
admet-2802	225	8	in	in	ADP
admet-2802	225	9	the	the	DET
admet-2802	225	10	tc	tc	PROPN
admet-2802	225	11	/	/	SYM
admet-2802	225	12	el	el	PROPN
admet-2802	225	13	bile	bile	NOUN
admet-2802	225	14	micelle	micelle	NOUN
admet-2802	225	15	media	medium	NOUN
admet-2802	225	16	(	(	PUNCT
admet-2802	225	17	mean	mean	PROPN
admet-2802	225	18	±	±	NUM
admet-2802	225	19	sd	sd	NOUN
admet-2802	225	20	,	,	PUNCT
admet-2802	225	21	n	n	NOUN
admet-2802	225	22	=	=	SYM
admet-2802	225	23	3	3	X
admet-2802	225	24	)	)	PUNCT
admet-2802	225	25	drug	drug	NOUN
admet-2802	225	26	kbm,0	kbm,0	PROPN
admet-2802	225	27	kbm,-1	kbm,-1	PROPN
admet-2802	225	28	kbm,-1	kbm,-1	PROPN
admet-2802	225	29	/	/	SYM
admet-2802	225	30	kbm,0	kbm,0	PROPN
admet-2802	225	31	flurbiprofen	flurbiprofen	VERB
admet-2802	225	32	3.93	3.93	NUM
admet-2802	225	33	±	±	NUM
admet-2802	225	34	0.14	0.14	NUM
admet-2802	225	35	×	×	NOUN
admet-2802	225	36	104	104	NUM
admet-2802	225	37	1.14	1.14	NUM
admet-2802	225	38	±	±	NUM
admet-2802	225	39	0.07	0.07	NUM
admet-2802	225	40	×	×	NOUN
admet-2802	225	41	103	103	NUM
admet-2802	225	42	0.03	0.03	NUM
admet-2802	225	43	furosemide	furosemide	VERB
admet-2802	225	44	3.80	3.80	NUM
admet-2802	225	45	±	±	NUM
admet-2802	225	46	0.04	0.04	NUM
admet-2802	225	47	×	×	NOUN
admet-2802	225	48	103	103	NUM
admet-2802	225	49	<	<	X
admet-2802	225	50	1.00	1.00	NUM
admet-2802	225	51	×102	×102	ADV
admet-2802	225	52	<	<	X
admet-2802	225	53	0.03	0.03	NUM
admet-2802	225	54	ibuprofen	ibuprofen	NOUN
admet-2802	225	55	2.29	2.29	NUM
admet-2802	225	56	±	±	NOUN
admet-2802	225	57	0.18	0.18	NUM
admet-2802	225	58	×	×	NOUN
admet-2802	225	59	104	104	NUM
admet-2802	225	60	5.33	5.33	NUM
admet-2802	225	61	±	±	NUM
admet-2802	225	62	1.16	1.16	NUM
admet-2802	225	63	×	×	NOUN
admet-2802	225	64	102	102	NUM
admet-2802	225	65	0.02	0.02	NUM
admet-2802	225	66	ketoprofen	ketoprofen	NOUN
admet-2802	225	67	3.91	3.91	NUM
admet-2802	225	68	±	±	NUM
admet-2802	225	69	0.12	0.12	NUM
admet-2802	225	70	×	×	NOUN
admet-2802	225	71	103	103	NUM
admet-2802	225	72	<	<	X
admet-2802	225	73	1.00	1.00	NUM
admet-2802	225	74	×	×	NOUN
admet-2802	225	75	102	102	NUM
admet-2802	225	76	<	<	X
admet-2802	225	77	0.03	0.03	NUM
admet-2802	225	78	in	in	ADP
admet-2802	225	79	the	the	DET
admet-2802	225	80	case	case	NOUN
admet-2802	225	81	of	of	ADP
admet-2802	225	82	monovalent	monovalent	NOUN
admet-2802	225	83	weak	weak	ADJ
admet-2802	225	84	acid	acid	NOUN
admet-2802	225	85	drugs	drug	NOUN
admet-2802	225	86	,	,	PUNCT
admet-2802	225	87	the	the	DET
admet-2802	225	88	bile	bile	NOUN
admet-2802	225	89	micelle	micelle	NOUN
admet-2802	225	90	binding	bind	VERB
admet-2802	225	91	decreased	decrease	VERB
admet-2802	225	92	as	as	SCONJ
admet-2802	225	93	ph	ph	NOUN
admet-2802	225	94	increased	increase	VERB
admet-2802	225	95	(	(	PUNCT
admet-2802	225	96	the	the	DET
admet-2802	225	97	fu	fu	NOUN
admet-2802	225	98	value	value	NOUN
admet-2802	225	99	increased	increase	VERB
admet-2802	225	100	as	as	ADP
admet-2802	225	101	a	a	DET
admet-2802	225	102	drug	drug	NOUN
admet-2802	225	103	became	become	VERB
admet-2802	225	104	ionized	ionized	ADJ
admet-2802	225	105	at	at	ADP
admet-2802	225	106	ph	ph	PROPN
admet-2802	225	107	>	>	X
admet-2802	225	108	pka	pka	PROPN
admet-2802	225	109	(	(	PUNCT
admet-2802	225	110	deprotonated	deprotonated	ADJ
admet-2802	225	111	)	)	PUNCT
admet-2802	225	112	)	)	PUNCT
admet-2802	226	1	(	(	PUNCT
admet-2802	226	2	figure	figure	NOUN
admet-2802	226	3	2	2	NUM
admet-2802	226	4	)	)	PUNCT
admet-2802	226	5	.	.	PUNCT
admet-2802	227	1	the	the	DET
admet-2802	227	2	kbm,-1	kbm,-1	PROPN
admet-2802	227	3	/	/	SYM
admet-2802	227	4	kbm,0	kbm,0	PROPN
admet-2802	227	5	ratio	ratio	NOUN
admet-2802	227	6	was	be	AUX
admet-2802	227	7	≤	≤	NOUN
admet-2802	227	8	0.03	0.03	NUM
admet-2802	227	9	for	for	ADP
admet-2802	227	10	all	all	DET
admet-2802	227	11	weak	weak	ADJ
admet-2802	227	12	acid	acid	NOUN
admet-2802	227	13	drugs	drug	NOUN
admet-2802	227	14	(	(	PUNCT
admet-2802	227	15	table	table	NOUN
admet-2802	227	16	2	2	NUM
admet-2802	227	17	)	)	PUNCT
admet-2802	227	18	.	.	PUNCT
admet-2802	228	1	like	like	ADP
admet-2802	228	2	the	the	DET
admet-2802	228	3	cases	case	NOUN
admet-2802	228	4	of	of	ADP
admet-2802	228	5	poct	poct	NOUN
admet-2802	228	6	and	and	CCONJ
admet-2802	228	7	kpc	kpc	NOUN
admet-2802	228	8	,	,	PUNCT
admet-2802	228	9	the	the	DET
admet-2802	228	10	bile	bile	NOUN
admet-2802	228	11	micelle	micelle	NOUN
admet-2802	228	12	binding	bind	VERB
admet-2802	228	13	of	of	ADP
admet-2802	228	14	anionic	anionic	ADJ
admet-2802	228	15	molecular	molecular	ADJ
admet-2802	228	16	species	specie	NOUN
admet-2802	228	17	(	(	PUNCT
admet-2802	228	18	z	z	NOUN
admet-2802	228	19	=	=	SYM
admet-2802	228	20	-1	-1	PRON
admet-2802	228	21	)	)	PUNCT
admet-2802	228	22	is	be	AUX
admet-2802	228	23	negligibly	negligibly	ADV
admet-2802	228	24	small	small	ADJ
admet-2802	228	25	compared	compare	VERB
admet-2802	228	26	to	to	ADP
admet-2802	228	27	un	un	ADJ
admet-2802	228	28	-	-	ADJ
admet-2802	228	29	ionized	ionize	VERB
admet-2802	228	30	molecular	molecular	ADJ
admet-2802	228	31	species	specie	NOUN
admet-2802	228	32	(	(	PUNCT
admet-2802	228	33	z	z	NOUN
admet-2802	228	34	=	=	NOUN
admet-2802	228	35	0	0	NUM
admet-2802	228	36	)	)	PUNCT
admet-2802	228	37	.	.	PUNCT
admet-2802	229	1	the	the	DET
admet-2802	229	2	negatively	negatively	ADV
admet-2802	229	3	charged	charge	VERB
admet-2802	229	4	moiety	moiety	NOUN
admet-2802	229	5	of	of	ADP
admet-2802	229	6	a	a	DET
admet-2802	229	7	drug	drug	NOUN
admet-2802	229	8	can	can	AUX
admet-2802	229	9	be	be	AUX
admet-2802	229	10	energetically	energetically	ADV
admet-2802	229	11	unfavourable	unfavourable	ADJ
admet-2802	229	12	for	for	ADP
admet-2802	229	13	partitioning	partition	VERB
admet-2802	229	14	to	to	ADP
admet-2802	229	15	both	both	CCONJ
admet-2802	229	16	the	the	DET
admet-2802	229	17	hydrophobic	hydrophobic	NOUN
admet-2802	229	18	core	core	NOUN
admet-2802	229	19	region	region	NOUN
admet-2802	229	20	and	and	CCONJ
admet-2802	229	21	the	the	DET
admet-2802	229	22	negatively	negatively	ADV
admet-2802	229	23	charged	charge	VERB
admet-2802	229	24	head	head	NOUN
admet-2802	229	25	group	group	NOUN
admet-2802	229	26	region	region	NOUN
admet-2802	229	27	of	of	ADP
admet-2802	229	28	the	the	DET
admet-2802	229	29	bile	bile	NOUN
admet-2802	229	30	micelles	micelle	NOUN
admet-2802	229	31	(	(	PUNCT
admet-2802	229	32	figure	figure	NOUN
admet-2802	229	33	3a	3a	NUM
admet-2802	229	34	)	)	PUNCT
admet-2802	229	35	.	.	PUNCT
admet-2802	230	1	figure	figure	VERB
admet-2802	230	2	3	3	NUM
admet-2802	230	3	.	.	PUNCT
admet-2802	230	4	interactions	interaction	NOUN
admet-2802	230	5	between	between	ADP
admet-2802	230	6	the	the	DET
admet-2802	230	7	charged	charge	VERB
admet-2802	230	8	moiety	moiety	NOUN
admet-2802	230	9	of	of	ADP
admet-2802	230	10	a	a	DET
admet-2802	230	11	drug	drug	NOUN
admet-2802	230	12	and	and	CCONJ
admet-2802	230	13	bile	bile	NOUN
admet-2802	230	14	micelles	micelle	NOUN
admet-2802	230	15	.	.	PUNCT
admet-2802	231	1	r	r	X
admet-2802	231	2	-	-	PUNCT
admet-2802	231	3	coo-	coo-	ADJ
admet-2802	231	4	:	:	PUNCT
admet-2802	231	5	ionized	ionized	ADJ
admet-2802	231	6	(	(	PUNCT
admet-2802	231	7	deprotonated	deprotonated	ADJ
admet-2802	231	8	)	)	PUNCT
admet-2802	231	9	carboxylic	carboxylic	ADJ
admet-2802	231	10	group	group	NOUN
admet-2802	231	11	,	,	PUNCT
admet-2802	231	12	r	r	NOUN
admet-2802	231	13	-	-	PUNCT
admet-2802	231	14	nh+	nh+	NOUN
admet-2802	231	15	:	:	PUNCT
admet-2802	231	16	ionized	ionized	ADJ
admet-2802	231	17	(	(	PUNCT
admet-2802	231	18	protonated	protonated	ADJ
admet-2802	231	19	)	)	PUNCT
admet-2802	231	20	amino	amino	NOUN
admet-2802	231	21	group	group	NOUN
admet-2802	231	22	.	.	PUNCT
admet-2802	232	1	monovalent	monovalent	NOUN
admet-2802	232	2	weak	weak	ADJ
admet-2802	232	3	base	base	NOUN
admet-2802	232	4	drugs	drug	NOUN
admet-2802	232	5	figure	figure	VERB
admet-2802	232	6	4	4	NUM
admet-2802	232	7	shows	show	VERB
admet-2802	232	8	the	the	DET
admet-2802	232	9	ph	ph	VERB
admet-2802	232	10	-	-	PUNCT
admet-2802	232	11	fu	fu	ADJ
admet-2802	232	12	profiles	profile	NOUN
admet-2802	232	13	of	of	ADP
admet-2802	232	14	monovalent	monovalent	NOUN
admet-2802	232	15	weak	weak	ADJ
admet-2802	232	16	base	base	NOUN
admet-2802	232	17	drugs	drug	NOUN
admet-2802	232	18	.	.	PUNCT
admet-2802	233	1	the	the	DET
admet-2802	233	2	theoretical	theoretical	ADJ
admet-2802	233	3	equations	equation	NOUN
admet-2802	233	4	(	(	PUNCT
admet-2802	233	5	eqs	eqs	X
admet-2802	233	6	.	.	PUNCT
admet-2802	233	7	(	(	PUNCT
admet-2802	233	8	4	4	NUM
admet-2802	233	9	)	)	PUNCT
admet-2802	233	10	and	and	CCONJ
admet-2802	233	11	(	(	PUNCT
admet-2802	233	12	5	5	NUM
admet-2802	233	13	)	)	PUNCT
admet-2802	233	14	)	)	PUNCT
admet-2802	233	15	appropriately	appropriately	ADV
admet-2802	233	16	described	describe	VERB
admet-2802	233	17	the	the	DET
admet-2802	233	18	ph	ph	VERB
admet-2802	233	19	-	-	PUNCT
admet-2802	233	20	fu	fu	NOUN
admet-2802	233	21	profiles	profile	NOUN
admet-2802	233	22	.	.	PUNCT
admet-2802	234	1	the	the	DET
admet-2802	234	2	kbm	kbm	NOUN
admet-2802	234	3	,	,	PUNCT
admet-2802	234	4	z	z	NOUN
admet-2802	234	5	values	value	NOUN
admet-2802	234	6	are	be	AUX
admet-2802	234	7	summarized	summarize	VERB
admet-2802	234	8	in	in	ADP
admet-2802	234	9	table	table	NOUN
admet-2802	234	10	3	3	NUM
admet-2802	234	11	.	.	PUNCT
admet-2802	234	12	figure	figure	NOUN
admet-2802	234	13	4	4	NUM
admet-2802	234	14	.	.	PUNCT
admet-2802	234	15	ph	ph	ADJ
admet-2802	234	16	-	-	PUNCT
admet-2802	234	17	fu	fu	NOUN
admet-2802	234	18	profile	profile	NOUN
admet-2802	234	19	of	of	ADP
admet-2802	234	20	monovalent	monovalent	ADJ
admet-2802	234	21	weak	weak	ADJ
admet-2802	234	22	bases	basis	NOUN
admet-2802	234	23	in	in	ADP
admet-2802	234	24	the	the	DET
admet-2802	234	25	tc	tc	PROPN
admet-2802	234	26	/	/	SYM
admet-2802	234	27	el	el	PROPN
admet-2802	234	28	bile	bile	NOUN
admet-2802	234	29	micelle	micelle	NOUN
admet-2802	234	30	media	medium	NOUN
admet-2802	234	31	(	(	PUNCT
admet-2802	234	32	mean	mean	PROPN
admet-2802	234	33	±	±	NUM
admet-2802	234	34	sd	sd	NOUN
admet-2802	234	35	,	,	PUNCT
admet-2802	234	36	n	n	NOUN
admet-2802	234	37	=	=	SYM
admet-2802	234	38	3	3	NUM
admet-2802	234	39	)	)	PUNCT
admet-2802	234	40	.	.	PUNCT
admet-2802	235	1	the	the	DET
admet-2802	235	2	solid	solid	ADJ
admet-2802	235	3	line	line	NOUN
admet-2802	235	4	is	be	AUX
admet-2802	235	5	the	the	DET
admet-2802	235	6	fitted	fit	VERB
admet-2802	235	7	theoretical	theoretical	ADJ
admet-2802	235	8	curve	curve	NOUN
admet-2802	235	9	in	in	ADP
admet-2802	235	10	the	the	DET
admet-2802	235	11	case	case	NOUN
admet-2802	235	12	of	of	ADP
admet-2802	235	13	monovalent	monovalent	ADJ
admet-2802	235	14	weak	weak	ADJ
admet-2802	235	15	base	base	NOUN
admet-2802	235	16	drugs	drug	NOUN
admet-2802	235	17	,	,	PUNCT
admet-2802	235	18	the	the	DET
admet-2802	235	19	fu	fu	NOUN
admet-2802	235	20	value	value	NOUN
admet-2802	235	21	either	either	CCONJ
admet-2802	235	22	increased	increase	VERB
admet-2802	235	23	or	or	CCONJ
admet-2802	235	24	decreased	decrease	VERB
admet-2802	235	25	as	as	SCONJ
admet-2802	235	26	ph	ph	NOUN
admet-2802	235	27	decreased	decrease	VERB
admet-2802	235	28	(	(	PUNCT
admet-2802	235	29	figure	figure	NOUN
admet-2802	235	30	3	3	NUM
admet-2802	235	31	)	)	PUNCT
admet-2802	235	32	.	.	PUNCT
admet-2802	236	1	the	the	DET
admet-2802	236	2	kbm,+1	kbm,+1	PROPN
admet-2802	236	3	/	/	SYM
admet-2802	236	4	kbm,0	kbm,0	PROPN
admet-2802	236	5	ratio	ratio	NOUN
admet-2802	236	6	ranged	range	VERB
admet-2802	236	7	from	from	ADP
admet-2802	236	8	0.24	0.24	NUM
admet-2802	236	9	to	to	ADP
admet-2802	236	10	2.6	2.6	NUM
admet-2802	236	11	(	(	PUNCT
admet-2802	236	12	table	table	NOUN
admet-2802	236	13	3	3	NUM
admet-2802	236	14	)	)	PUNCT
admet-2802	236	15	,	,	PUNCT
admet-2802	236	16	unlike	unlike	ADP
admet-2802	236	17	the	the	DET
admet-2802	236	18	cases	case	NOUN
admet-2802	236	19	of	of	ADP
admet-2802	236	20	octanol	octanol	NOUN
admet-2802	236	21	and	and	CCONJ
admet-2802	236	22	pc	pc	NOUN
admet-2802	236	23	liposome	liposome	NOUN
admet-2802	236	24	partitioning	partitioning	NOUN
admet-2802	236	25	(	(	PUNCT
admet-2802	236	26	poct,+1	poct,+1	NOUN
admet-2802	236	27	/	/	SYM
admet-2802	236	28	poct,0	poct,0	NOUN
admet-2802	236	29	≈	≈	NOUN
admet-2802	236	30	0.001	0.001	NUM
admet-2802	236	31	,	,	PUNCT
admet-2802	236	32	kpc,+1	kpc,+1	PROPN
admet-2802	236	33	/	/	SYM
admet-2802	236	34	kpc,0	kpc,0	NOUN
admet-2802	237	1	≈	≈	PROPN
admet-2802	237	2	0.1	0.1	NUM
admet-2802	237	3	)	)	PUNCT
admet-2802	238	1	[	[	X
admet-2802	238	2	12	12	NUM
admet-2802	238	3	-	-	SYM
admet-2802	238	4	14	14	NUM
admet-2802	238	5	]	]	PUNCT
admet-2802	238	6	.	.	PUNCT
admet-2802	239	1	structurally	structurally	ADV
admet-2802	239	2	diverse	diverse	ADJ
admet-2802	239	3	cationic	cationic	ADJ
admet-2802	239	4	molecular	molecular	ADJ
admet-2802	239	5	species	specie	NOUN
admet-2802	239	6	(	(	PUNCT
admet-2802	239	7	z	z	NOUN
admet-2802	239	8	=	=	SYM
admet-2802	239	9	+1	+1	PROPN
admet-2802	239	10	)	)	PUNCT
admet-2802	239	11	can	can	AUX
admet-2802	239	12	bind	bind	VERB
admet-2802	239	13	to	to	ADP
admet-2802	239	14	bile	bile	NOUN
admet-2802	239	15	micelles	micelle	NOUN
admet-2802	239	16	.	.	PUNCT
admet-2802	240	1	however	however	ADV
admet-2802	240	2	,	,	PUNCT
admet-2802	240	3	no	no	DET
admet-2802	240	4	general	general	ADJ
admet-2802	240	5	rule	rule	NOUN
admet-2802	240	6	was	be	AUX
admet-2802	240	7	found	find	VERB
admet-2802	240	8	for	for	ADP
admet-2802	240	9	kbm,+1	kbm,+1	PROPN
admet-2802	240	10	/	/	SYM
admet-2802	240	11	kbm,0	kbm,0	PROPN
admet-2802	240	12	.	.	PUNCT
admet-2802	241	1	therefore	therefore	ADV
admet-2802	241	2	,	,	PUNCT
admet-2802	241	3	kbm,+1	kbm,+1	PROPN
admet-2802	241	4	/	/	SYM
admet-2802	241	5	kbm,0	kbm,0	PROPN
admet-2802	241	6	is	be	AUX
admet-2802	241	7	not	not	PART
admet-2802	241	8	simply	simply	ADV
admet-2802	241	9	explained	explain	VERB
admet-2802	241	10	by	by	ADP
admet-2802	241	11	ionic	ionic	ADJ
admet-2802	241	12	interaction	interaction	NOUN
admet-2802	241	13	.	.	PUNCT
admet-2802	242	1	the	the	DET
admet-2802	242	2	positively	positively	ADV
admet-2802	242	3	charged	charge	VERB
admet-2802	242	4	moiety	moiety	NOUN
admet-2802	242	5	of	of	ADP
admet-2802	242	6	a	a	DET
admet-2802	242	7	drug	drug	NOUN
admet-2802	242	8	can	can	AUX
admet-2802	242	9	be	be	AUX
admet-2802	242	10	energetically	energetically	ADV
admet-2802	242	11	unfavourable	unfavourable	ADJ
admet-2802	242	12	for	for	ADP
admet-2802	242	13	partitioning	partition	VERB
admet-2802	242	14	to	to	ADP
admet-2802	242	15	the	the	DET
admet-2802	242	16	hydrophobic	hydrophobic	NOUN
admet-2802	242	17	core	core	NOUN
admet-2802	242	18	region	region	NOUN
admet-2802	242	19	of	of	ADP
admet-2802	242	20	bile	bile	NOUN
admet-2802	242	21	micelles	micelle	NOUN
admet-2802	242	22	;	;	PUNCT
admet-2802	242	23	however	however	ADV
admet-2802	242	24	,	,	PUNCT
admet-2802	242	25	favourable	favourable	ADJ
admet-2802	242	26	for	for	ADP
admet-2802	242	27	partitioning	partition	VERB
admet-2802	242	28	to	to	ADP
admet-2802	242	29	the	the	DET
admet-2802	242	30	negatively	negatively	ADV
admet-2802	242	31	charged	charge	VERB
admet-2802	242	32	head	head	NOUN
admet-2802	242	33	group	group	NOUN
admet-2802	242	34	region	region	NOUN
admet-2802	242	35	of	of	ADP
admet-2802	242	36	bile	bile	NOUN
admet-2802	242	37	micelles	micelle	NOUN
admet-2802	242	38	(	(	PUNCT
admet-2802	242	39	figure	figure	NOUN
admet-2802	242	40	3b	3b	NUM
admet-2802	242	41	)	)	PUNCT
admet-2802	242	42	.	.	PUNCT
admet-2802	243	1	f	f	PROPN
admet-2802	243	2	u	u	NOUN
admet-2802	243	3	f	f	PROPN
admet-2802	243	4	u	u	X
admet-2802	243	5	f	f	PROPN
admet-2802	243	6	u	u	X
admet-2802	243	7	f	f	PROPN
admet-2802	243	8	u	u	X
admet-2802	243	9	f	f	PROPN
admet-2802	243	10	u	u	X
admet-2802	243	11	f	f	PROPN
admet-2802	243	12	u	u	X
admet-2802	243	13	f	f	PROPN
admet-2802	243	14	u	u	X
admet-2802	243	15	f	f	PROPN
admet-2802	243	16	u	u	PROPN
admet-2802	243	17	admet	admet	X
admet-2802	243	18	&	&	CCONJ
admet-2802	243	19	dmpk	dmpk	PROPN
admet-2802	243	20	13(4	13(4	NUM
admet-2802	243	21	)	)	PUNCT
admet-2802	243	22	(	(	PUNCT
admet-2802	243	23	2025	2025	NUM
admet-2802	243	24	)	)	PUNCT
admet-2802	243	25	2802	2802	NUM
admet-2802	243	26	bile	bile	NOUN
admet-2802	243	27	micelle	micelle	NOUN
admet-2802	243	28	binding	bind	VERB
admet-2802	243	29	of	of	ADP
admet-2802	243	30	structurally	structurally	ADV
admet-2802	243	31	diverse	diverse	ADJ
admet-2802	243	32	ionized	ionized	ADJ
admet-2802	243	33	drugs	drug	NOUN
admet-2802	243	34	doi	doi	NOUN
admet-2802	243	35	:	:	PUNCT
admet-2802	243	36	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	243	37	7	7	NUM
admet-2802	243	38	table	table	NOUN
admet-2802	243	39	3	3	NUM
admet-2802	243	40	.	.	PUNCT
admet-2802	244	1	kbm	kbm	NOUN
admet-2802	244	2	values	value	NOUN
admet-2802	244	3	of	of	ADP
admet-2802	244	4	monovalent	monovalent	NOUN
admet-2802	244	5	weak	weak	ADJ
admet-2802	244	6	base	base	NOUN
admet-2802	244	7	drugs	drug	NOUN
admet-2802	244	8	in	in	ADP
admet-2802	244	9	the	the	DET
admet-2802	244	10	tc	tc	PROPN
admet-2802	244	11	/	/	SYM
admet-2802	244	12	el	el	PROPN
admet-2802	244	13	bile	bile	NOUN
admet-2802	244	14	micelle	micelle	NOUN
admet-2802	244	15	media	medium	NOUN
admet-2802	244	16	(	(	PUNCT
admet-2802	244	17	mean	mean	PROPN
admet-2802	244	18	±	±	NUM
admet-2802	244	19	sd	sd	NOUN
admet-2802	244	20	,	,	PUNCT
admet-2802	244	21	n	n	NOUN
admet-2802	244	22	=	=	SYM
admet-2802	244	23	3	3	X
admet-2802	244	24	)	)	PUNCT
admet-2802	244	25	drug	drug	NOUN
admet-2802	244	26	kbm,0	kbm,0	PROPN
admet-2802	244	27	kbm	kbm	PROPN
admet-2802	244	28	,	,	PUNCT
admet-2802	244	29	+1	+1	PROPN
admet-2802	244	30	kbm,+1	kbm,+1	PROPN
admet-2802	244	31	/	/	SYM
admet-2802	244	32	kbm,0	kbm,0	PROPN
admet-2802	244	33	diphenhydramine	diphenhydramine	PROPN
admet-2802	244	34	5.40	5.40	NUM
admet-2802	244	35	±	±	NUM
admet-2802	244	36	0.34	0.34	NUM
admet-2802	244	37	×	×	NOUN
admet-2802	244	38	103	103	NUM
admet-2802	244	39	2.30	2.30	NUM
admet-2802	244	40	±	±	NUM
admet-2802	244	41	0.04	0.04	NUM
admet-2802	244	42	×	×	NOUN
admet-2802	244	43	103	103	NUM
admet-2802	244	44	0.43	0.43	NUM
admet-2802	244	45	papaverine	papaverine	VERB
admet-2802	244	46	3.91	3.91	NUM
admet-2802	244	47	±	±	NOUN
admet-2802	244	48	0.16	0.16	NUM
admet-2802	244	49	×	×	NOUN
admet-2802	244	50	103	103	NUM
admet-2802	244	51	1.52	1.52	NUM
admet-2802	244	52	±	±	NUM
admet-2802	244	53	0.03	0.03	NUM
admet-2802	244	54	×	×	NOUN
admet-2802	244	55	103	103	NUM
admet-2802	244	56	0.39	0.39	NUM
admet-2802	244	57	propranolol	propranolol	NOUN
admet-2802	244	58	9.66	9.66	NUM
admet-2802	244	59	±	±	NOUN
admet-2802	244	60	0.20	0.20	NUM
admet-2802	244	61	×	×	NOUN
admet-2802	244	62	103	103	NUM
admet-2802	244	63	9.64	9.64	NUM
admet-2802	244	64	±	±	NUM
admet-2802	244	65	0.40	0.40	NUM
admet-2802	244	66	×	×	NOUN
admet-2802	244	67	103	103	NUM
admet-2802	244	68	1.00	1.00	NUM
admet-2802	244	69	pyrimethamine	pyrimethamine	NOUN
admet-2802	244	70	4.61	4.61	NUM
admet-2802	244	71	±	±	NUM
admet-2802	244	72	0.27	0.27	NUM
admet-2802	244	73	×	×	NOUN
admet-2802	244	74	103	103	NUM
admet-2802	244	75	1.66	1.66	NUM
admet-2802	244	76	±	±	NUM
admet-2802	244	77	0.16	0.16	NUM
admet-2802	244	78	×	×	NOUN
admet-2802	244	79	103	103	NUM
admet-2802	244	80	0.36	0.36	NUM
admet-2802	244	81	talinolol	talinolol	NOUN
admet-2802	244	82	4.75	4.75	NUM
admet-2802	244	83	±	±	NOUN
admet-2802	244	84	1.00	1.00	NUM
admet-2802	244	85	×	×	NOUN
admet-2802	244	86	102	102	NUM
admet-2802	244	87	1.19	1.19	NUM
admet-2802	244	88	±	±	NUM
admet-2802	244	89	0.11	0.11	NUM
admet-2802	244	90	×	×	NOUN
admet-2802	244	91	103	103	NUM
admet-2802	244	92	2.60	2.60	NUM
admet-2802	244	93	tamsulosin	tamsulosin	NOUN
admet-2802	244	94	5.42	5.42	NUM
admet-2802	244	95	±	±	NUM
admet-2802	244	96	1.29	1.29	NUM
admet-2802	244	97	×	×	NOUN
admet-2802	244	98	102	102	NUM
admet-2802	244	99	5.89	5.89	NUM
admet-2802	244	100	±	±	NUM
admet-2802	244	101	0.39	0.39	NUM
admet-2802	244	102	×	×	NOUN
admet-2802	244	103	102	102	NUM
admet-2802	244	104	1.13	1.13	NUM
admet-2802	244	105	verapamil	verapamil	NOUN
admet-2802	244	106	1.60	1.60	NUM
admet-2802	244	107	±	±	NUM
admet-2802	244	108	0.02	0.02	NUM
admet-2802	244	109	×	×	NOUN
admet-2802	244	110	104	104	NUM
admet-2802	244	111	3.87	3.87	NUM
admet-2802	244	112	±	±	NUM
admet-2802	244	113	0.23	0.23	NUM
admet-2802	244	114	×	×	NOUN
admet-2802	244	115	103	103	NUM
admet-2802	244	116	0.24	0.24	NUM
admet-2802	244	117	vibegron	vibegron	NOUN
admet-2802	244	118	1.67	1.67	NUM
admet-2802	244	119	±	±	NUM
admet-2802	244	120	0.06	0.06	NUM
admet-2802	244	121	×	×	NOUN
admet-2802	244	122	103	103	NUM
admet-2802	244	123	5.80	5.80	NUM
admet-2802	244	124	±	±	NUM
admet-2802	244	125	1.80	1.80	NUM
admet-2802	244	126	×	×	NOUN
admet-2802	244	127	102	102	NUM
admet-2802	244	128	0.35	0.35	NUM
admet-2802	244	129	the	the	DET
admet-2802	244	130	balance	balance	NOUN
admet-2802	244	131	of	of	ADP
admet-2802	244	132	these	these	DET
admet-2802	244	133	two	two	NUM
admet-2802	244	134	factors	factor	NOUN
admet-2802	244	135	can	can	AUX
admet-2802	244	136	determine	determine	VERB
admet-2802	244	137	the	the	DET
admet-2802	244	138	kbm,+1	kbm,+1	PROPN
admet-2802	244	139	/	/	SYM
admet-2802	244	140	kbm,0	kbm,0	ADJ
admet-2802	244	141	value	value	NOUN
admet-2802	244	142	.	.	PUNCT
admet-2802	245	1	in	in	ADP
admet-2802	245	2	the	the	DET
admet-2802	245	3	case	case	NOUN
admet-2802	245	4	of	of	ADP
admet-2802	245	5	kbm,+1	kbm,+1	PROPN
admet-2802	245	6	/	/	SYM
admet-2802	245	7	kbm,0	kbm,0	PROPN
admet-2802	245	8	>	>	X
admet-2802	245	9	1.0	1.0	NUM
admet-2802	245	10	,	,	PUNCT
admet-2802	245	11	the	the	DET
admet-2802	245	12	sulfonate	sulfonate	ADJ
admet-2802	245	13	group	group	NOUN
admet-2802	245	14	of	of	ADP
admet-2802	245	15	taurocholates	taurocholate	NOUN
admet-2802	245	16	(	(	PUNCT
admet-2802	245	17	r	r	X
admet-2802	245	18	-	-	PUNCT
admet-2802	245	19	so3	so3	NOUN
admet-2802	245	20	-	-	PUNCT
admet-2802	245	21	)	)	PUNCT
admet-2802	245	22	and	and	CCONJ
admet-2802	245	23	the	the	DET
admet-2802	245	24	ammonium	ammonium	NOUN
admet-2802	245	25	moiety	moiety	NOUN
admet-2802	245	26	of	of	ADP
admet-2802	245	27	a	a	DET
admet-2802	245	28	drug	drug	NOUN
admet-2802	245	29	(	(	PUNCT
admet-2802	245	30	r3nh+	r3nh+	NOUN
admet-2802	245	31	)	)	PUNCT
admet-2802	245	32	might	might	AUX
admet-2802	245	33	have	have	VERB
admet-2802	245	34	a	a	DET
admet-2802	245	35	strong	strong	ADJ
admet-2802	245	36	attractive	attractive	ADJ
admet-2802	245	37	electrostatic	electrostatic	ADJ
admet-2802	245	38	interaction	interaction	NOUN
admet-2802	245	39	[	[	X
admet-2802	245	40	29	29	NUM
admet-2802	245	41	]	]	PUNCT
admet-2802	245	42	.	.	PUNCT
admet-2802	246	1	however	however	ADV
admet-2802	246	2	,	,	PUNCT
admet-2802	246	3	in	in	ADP
admet-2802	246	4	the	the	DET
admet-2802	246	5	cases	case	NOUN
admet-2802	246	6	of	of	ADP
admet-2802	246	7	kbm,+1	kbm,+1	NOUN
admet-2802	246	8	/	/	SYM
admet-2802	246	9	kbm,0	kbm,0	PROPN
admet-2802	246	10	<	<	X
admet-2802	246	11	1.0	1.0	NUM
admet-2802	246	12	,	,	PUNCT
admet-2802	246	13	the	the	DET
admet-2802	246	14	cationic	cationic	ADJ
admet-2802	246	15	charge	charge	NOUN
admet-2802	246	16	is	be	AUX
admet-2802	246	17	less	less	ADV
admet-2802	246	18	favourable	favourable	ADJ
admet-2802	246	19	for	for	ADP
admet-2802	246	20	partitioning	partition	VERB
admet-2802	246	21	into	into	ADP
admet-2802	246	22	the	the	DET
admet-2802	246	23	hydrophobic	hydrophobic	NOUN
admet-2802	246	24	core	core	NOUN
admet-2802	246	25	region	region	NOUN
admet-2802	246	26	of	of	ADP
admet-2802	246	27	bile	bile	NOUN
admet-2802	246	28	micelles	micelle	NOUN
admet-2802	246	29	.	.	PUNCT
admet-2802	247	1	in	in	ADP
admet-2802	247	2	the	the	DET
admet-2802	247	3	present	present	ADJ
admet-2802	247	4	study	study	NOUN
admet-2802	247	5	,	,	PUNCT
admet-2802	247	6	kbm,+1	kbm,+1	PROPN
admet-2802	247	7	/	/	SYM
admet-2802	247	8	kbm,0	kbm,0	PROPN
admet-2802	247	9	of	of	ADP
admet-2802	247	10	propranolol	propranolol	PROPN
admet-2802	247	11	and	and	CCONJ
admet-2802	247	12	talinolol	talinolol	NOUN
admet-2802	247	13	were	be	AUX
admet-2802	247	14	≥	≥	NOUN
admet-2802	247	15	1.0	1.0	NUM
admet-2802	247	16	(	(	PUNCT
admet-2802	247	17	1.0	1.0	NUM
admet-2802	247	18	and	and	CCONJ
admet-2802	247	19	2.6	2.6	NUM
admet-2802	247	20	,	,	PUNCT
admet-2802	247	21	respectively	respectively	ADV
admet-2802	247	22	)	)	PUNCT
admet-2802	247	23	.	.	PUNCT
admet-2802	248	1	previously	previously	ADV
admet-2802	248	2	,	,	PUNCT
admet-2802	248	3	kbm,+1	kbm,+1	PROPN
admet-2802	248	4	/	/	SYM
admet-2802	248	5	kbm,0	kbm,0	PROPN
admet-2802	248	6	of	of	ADP
admet-2802	248	7	atenolol	atenolol	PROPN
admet-2802	248	8	and	and	CCONJ
admet-2802	248	9	nadolol	nadolol	NOUN
admet-2802	248	10	in	in	ADP
admet-2802	248	11	deoxycholate	deoxycholate	PROPN
admet-2802	248	12	/	/	SYM
admet-2802	248	13	el	el	PROPN
admet-2802	248	14	micelles	micelle	NOUN
admet-2802	248	15	were	be	AUX
admet-2802	248	16	also	also	ADV
admet-2802	248	17	reported	report	VERB
admet-2802	248	18	to	to	PART
admet-2802	248	19	be	be	AUX
admet-2802	248	20	>	>	X
admet-2802	248	21	1.0	1.0	NUM
admet-2802	248	22	(	(	PUNCT
admet-2802	248	23	1.3	1.3	NUM
admet-2802	248	24	and	and	CCONJ
admet-2802	248	25	1.7	1.7	NUM
admet-2802	248	26	,	,	PUNCT
admet-2802	248	27	respectively	respectively	ADV
admet-2802	248	28	)	)	PUNCT
admet-2802	249	1	[	[	X
admet-2802	249	2	16	16	NUM
admet-2802	249	3	]	]	PUNCT
admet-2802	249	4	.	.	PUNCT
admet-2802	250	1	for	for	ADP
admet-2802	250	2	βblockers	βblocker	NOUN
admet-2802	250	3	,	,	PUNCT
admet-2802	250	4	kbm,+1	kbm,+1	PROPN
admet-2802	250	5	/	/	SYM
admet-2802	250	6	kbm,0	kbm,0	PROPN
admet-2802	250	7	may	may	AUX
admet-2802	250	8	be	be	AUX
admet-2802	250	9	generally	generally	ADV
admet-2802	250	10	≥	≥	NOUN
admet-2802	250	11	1.0	1.0	NUM
admet-2802	250	12	.	.	PUNCT
admet-2802	251	1	divalent	divalent	VERB
admet-2802	251	2	weak	weak	ADJ
admet-2802	251	3	bases	basis	NOUN
admet-2802	251	4	figure	figure	VERB
admet-2802	251	5	5	5	NUM
admet-2802	251	6	shows	show	VERB
admet-2802	251	7	the	the	DET
admet-2802	251	8	ph	ph	VERB
admet-2802	251	9	-	-	PUNCT
admet-2802	251	10	fu	fu	ADJ
admet-2802	251	11	profiles	profile	NOUN
admet-2802	251	12	of	of	ADP
admet-2802	251	13	divalent	divalent	ADJ
admet-2802	251	14	weak	weak	ADJ
admet-2802	251	15	base	base	NOUN
admet-2802	251	16	drugs	drug	NOUN
admet-2802	251	17	.	.	PUNCT
admet-2802	252	1	the	the	DET
admet-2802	252	2	theoretical	theoretical	ADJ
admet-2802	252	3	equations	equation	NOUN
admet-2802	252	4	(	(	PUNCT
admet-2802	252	5	eqs	eqs	X
admet-2802	252	6	.	.	PUNCT
admet-2802	252	7	(	(	PUNCT
admet-2802	252	8	6	6	NUM
admet-2802	252	9	)	)	PUNCT
admet-2802	252	10	and	and	CCONJ
admet-2802	252	11	(	(	PUNCT
admet-2802	252	12	7	7	NUM
admet-2802	252	13	)	)	PUNCT
admet-2802	252	14	)	)	PUNCT
admet-2802	252	15	appropriately	appropriately	ADV
admet-2802	252	16	described	describe	VERB
admet-2802	252	17	the	the	DET
admet-2802	252	18	ph	ph	VERB
admet-2802	252	19	-	-	PUNCT
admet-2802	252	20	fu	fu	NOUN
admet-2802	252	21	profiles	profile	NOUN
admet-2802	252	22	.	.	PUNCT
admet-2802	253	1	the	the	DET
admet-2802	253	2	kbm	kbm	NOUN
admet-2802	253	3	,	,	PUNCT
admet-2802	253	4	z	z	NOUN
admet-2802	253	5	values	value	NOUN
admet-2802	253	6	are	be	AUX
admet-2802	253	7	summarized	summarize	VERB
admet-2802	253	8	in	in	ADP
admet-2802	253	9	table	table	NOUN
admet-2802	253	10	4	4	NUM
admet-2802	253	11	.	.	PUNCT
admet-2802	254	1	in	in	ADP
admet-2802	254	2	the	the	DET
admet-2802	254	3	case	case	NOUN
admet-2802	254	4	of	of	ADP
admet-2802	254	5	the	the	DET
admet-2802	254	6	divalent	divalent	ADJ
admet-2802	254	7	weak	weak	ADJ
admet-2802	254	8	base	base	NOUN
admet-2802	254	9	drugs	drug	NOUN
admet-2802	254	10	(	(	PUNCT
admet-2802	254	11	quinidine	quinidine	ADJ
admet-2802	254	12	and	and	CCONJ
admet-2802	254	13	quinine	quinine	ADJ
admet-2802	254	14	)	)	PUNCT
admet-2802	254	15	,	,	PUNCT
admet-2802	254	16	the	the	DET
admet-2802	254	17	bile	bile	NOUN
admet-2802	254	18	micelle	micelle	NOUN
admet-2802	254	19	binding	bind	VERB
admet-2802	254	20	decreased	decrease	VERB
admet-2802	254	21	(	(	PUNCT
admet-2802	254	22	the	the	DET
admet-2802	254	23	fu	fu	PROPN
admet-2802	254	24	value	value	NOUN
admet-2802	254	25	increased	increase	VERB
admet-2802	254	26	)	)	PUNCT
admet-2802	254	27	step	step	NOUN
admet-2802	254	28	by	by	ADP
admet-2802	254	29	step	step	NOUN
admet-2802	254	30	with	with	ADP
admet-2802	254	31	decreasing	decrease	VERB
admet-2802	254	32	ph	ph	NOUN
admet-2802	254	33	below	below	ADP
admet-2802	254	34	each	each	DET
admet-2802	254	35	pka	pka	NOUN
admet-2802	254	36	(	(	PUNCT
admet-2802	254	37	figure	figure	NOUN
admet-2802	254	38	4	4	NUM
admet-2802	254	39	)	)	PUNCT
admet-2802	254	40	.	.	PUNCT
admet-2802	255	1	the	the	DET
admet-2802	255	2	kbm,+1	kbm,+1	PROPN
admet-2802	255	3	/	/	SYM
admet-2802	255	4	kbm,0	kbm,0	PROPN
admet-2802	255	5	and	and	CCONJ
admet-2802	255	6	kbm,+2	kbm,+2	PROPN
admet-2802	255	7	/	/	SYM
admet-2802	255	8	kbm,0	kbm,0	ADJ
admet-2802	255	9	ratios	ratio	NOUN
admet-2802	255	10	were	be	AUX
admet-2802	255	11	about	about	ADV
admet-2802	255	12	0.8	0.8	NUM
admet-2802	255	13	to	to	PART
admet-2802	255	14	0.9	0.9	NUM
admet-2802	255	15	and	and	CCONJ
admet-2802	255	16	0.3	0.3	NUM
admet-2802	255	17	,	,	PUNCT
admet-2802	255	18	respectively	respectively	ADV
admet-2802	255	19	(	(	PUNCT
admet-2802	255	20	table	table	NOUN
admet-2802	255	21	4	4	NUM
admet-2802	255	22	)	)	PUNCT
admet-2802	255	23	.	.	PUNCT
admet-2802	256	1	in	in	ADP
admet-2802	256	2	these	these	DET
admet-2802	256	3	cases	case	NOUN
admet-2802	256	4	,	,	PUNCT
admet-2802	256	5	the	the	DET
admet-2802	256	6	first	first	ADJ
admet-2802	256	7	and	and	CCONJ
admet-2802	256	8	second	second	ADJ
admet-2802	256	9	positive	positive	ADJ
admet-2802	256	10	charges	charge	NOUN
admet-2802	256	11	are	be	AUX
admet-2802	256	12	both	both	CCONJ
admet-2802	256	13	unfavourable	unfavourable	ADJ
admet-2802	256	14	for	for	ADP
admet-2802	256	15	bile	bile	NOUN
admet-2802	256	16	micelle	micelle	NOUN
admet-2802	256	17	binding	bind	VERB
admet-2802	256	18	.	.	PUNCT
admet-2802	257	1	the	the	DET
admet-2802	257	2	kbm	kbm	NOUN
admet-2802	257	3	values	value	NOUN
admet-2802	257	4	of	of	ADP
admet-2802	257	5	quinidine	quinidine	PROPN
admet-2802	257	6	and	and	CCONJ
admet-2802	257	7	quinine	quinine	ADJ
admet-2802	257	8	are	be	AUX
admet-2802	257	9	almost	almost	ADV
admet-2802	257	10	the	the	DET
admet-2802	257	11	same	same	ADJ
admet-2802	257	12	,	,	PUNCT
admet-2802	257	13	suggesting	suggest	VERB
admet-2802	257	14	that	that	SCONJ
admet-2802	257	15	diastereomers	diastereomer	NOUN
admet-2802	257	16	may	may	AUX
admet-2802	257	17	show	show	VERB
admet-2802	257	18	similar	similar	ADJ
admet-2802	257	19	kbm	kbm	NOUN
admet-2802	257	20	values	value	NOUN
admet-2802	257	21	,	,	PUNCT
admet-2802	257	22	even	even	ADV
admet-2802	257	23	though	though	SCONJ
admet-2802	257	24	tc	tc	NUM
admet-2802	257	25	and	and	CCONJ
admet-2802	257	26	el	el	PROPN
admet-2802	257	27	are	be	AUX
admet-2802	257	28	chiral	chiral	ADJ
admet-2802	257	29	.	.	PUNCT
admet-2802	258	1	figure	figure	NOUN
admet-2802	258	2	5	5	NUM
admet-2802	258	3	.	.	PUNCT
admet-2802	258	4	ph	ph	ADJ
admet-2802	258	5	-	-	PUNCT
admet-2802	258	6	fu	fu	ADJ
admet-2802	258	7	profile	profile	NOUN
admet-2802	258	8	of	of	ADP
admet-2802	258	9	divalent	divalent	ADJ
admet-2802	258	10	weak	weak	ADJ
admet-2802	258	11	base	base	NOUN
admet-2802	258	12	drugs	drug	NOUN
admet-2802	258	13	in	in	ADP
admet-2802	258	14	the	the	DET
admet-2802	258	15	tc	tc	PROPN
admet-2802	258	16	/	/	SYM
admet-2802	258	17	el	el	PROPN
admet-2802	258	18	bile	bile	NOUN
admet-2802	258	19	micelle	micelle	NOUN
admet-2802	258	20	media	medium	NOUN
admet-2802	258	21	(	(	PUNCT
admet-2802	258	22	mean	mean	PROPN
admet-2802	258	23	±	±	NUM
admet-2802	258	24	s.d	s.d	PROPN
admet-2802	258	25	.	.	PROPN
admet-2802	258	26	,	,	PUNCT
admet-2802	258	27	n	n	PROPN
admet-2802	258	28	=	=	SYM
admet-2802	258	29	3	3	NUM
admet-2802	258	30	)	)	PUNCT
admet-2802	258	31	.	.	PUNCT
admet-2802	259	1	the	the	DET
admet-2802	259	2	solid	solid	ADJ
admet-2802	259	3	line	line	NOUN
admet-2802	259	4	is	be	AUX
admet-2802	259	5	the	the	DET
admet-2802	259	6	fitted	fit	VERB
admet-2802	259	7	theoretical	theoretical	ADJ
admet-2802	259	8	curve	curve	NOUN
admet-2802	259	9	table	table	NOUN
admet-2802	259	10	4	4	NUM
admet-2802	259	11	.	.	PUNCT
admet-2802	260	1	kbm	kbm	NOUN
admet-2802	260	2	values	value	NOUN
admet-2802	260	3	of	of	ADP
admet-2802	260	4	divalent	divalent	ADJ
admet-2802	260	5	base	base	NOUN
admet-2802	260	6	drugs	drug	NOUN
admet-2802	260	7	in	in	ADP
admet-2802	260	8	the	the	DET
admet-2802	260	9	tc	tc	PROPN
admet-2802	260	10	/	/	SYM
admet-2802	260	11	el	el	PROPN
admet-2802	260	12	bile	bile	NOUN
admet-2802	260	13	micelle	micelle	NOUN
admet-2802	260	14	media	medium	NOUN
admet-2802	260	15	(	(	PUNCT
admet-2802	260	16	mean	mean	PROPN
admet-2802	260	17	±	±	NUM
admet-2802	260	18	s.d	s.d	PROPN
admet-2802	260	19	.	.	PROPN
admet-2802	260	20	,	,	PUNCT
admet-2802	260	21	n	n	NOUN
admet-2802	260	22	=	=	SYM
admet-2802	260	23	3	3	X
admet-2802	260	24	)	)	PUNCT
admet-2802	260	25	drug	drug	NOUN
admet-2802	260	26	kbm,0	kbm,0	PROPN
admet-2802	260	27	kbm,+1	kbm,+1	PROPN
admet-2802	260	28	kbm,+2	kbm,+2	VERB
admet-2802	260	29	kbm,+1	kbm,+1	PROPN
admet-2802	260	30	/	/	SYM
admet-2802	260	31	kbm,0	kbm,0	PROPN
admet-2802	260	32	kbm,+2	kbm,+2	PROPN
admet-2802	260	33	/	/	SYM
admet-2802	260	34	kbm,0	kbm,0	ADJ
admet-2802	260	35	quinidine	quinidine	PROPN
admet-2802	260	36	1.47	1.47	NUM
admet-2802	260	37	±	±	NUM
admet-2802	260	38	0.08	0.08	NUM
admet-2802	260	39	×	×	NOUN
admet-2802	260	40	103	103	NUM
admet-2802	260	41	1.15	1.15	NUM
admet-2802	260	42	±	±	NUM
admet-2802	260	43	0.03	0.03	NUM
admet-2802	260	44	×	×	NOUN
admet-2802	260	45	103	103	NUM
admet-2802	260	46	3.75	3.75	NUM
admet-2802	260	47	±	±	NUM
admet-2802	260	48	1.23	1.23	NUM
admet-2802	260	49	×	×	NOUN
admet-2802	260	50	102	102	NUM
admet-2802	260	51	0.79	0.79	NUM
admet-2802	260	52	0.26	0.26	NUM
admet-2802	260	53	quinine	quinine	NOUN
admet-2802	260	54	1.58	1.58	NUM
admet-2802	260	55	±	±	NUM
admet-2802	260	56	0.07	0.07	NUM
admet-2802	260	57	×	×	NOUN
admet-2802	260	58	103	103	NUM
admet-2802	260	59	1.47	1.47	NUM
admet-2802	260	60	±	±	NUM
admet-2802	260	61	0.02	0.02	NUM
admet-2802	260	62	×	×	NOUN
admet-2802	260	63	103	103	NUM
admet-2802	260	64	5.27	5.27	NUM
admet-2802	260	65	±	±	NUM
admet-2802	260	66	0.43	0.43	NUM
admet-2802	260	67	×	×	NOUN
admet-2802	260	68	102	102	NUM
admet-2802	260	69	0.93	0.93	NUM
admet-2802	260	70	0.34	0.34	NUM
admet-2802	260	71	zwitterionic	zwitterionic	ADJ
admet-2802	260	72	drugs	drug	NOUN
admet-2802	260	73	figure	figure	VERB
admet-2802	260	74	6	6	NUM
admet-2802	260	75	shows	show	VERB
admet-2802	260	76	the	the	DET
admet-2802	260	77	ph	ph	VERB
admet-2802	260	78	-	-	PUNCT
admet-2802	260	79	fu	fu	ADJ
admet-2802	260	80	profiles	profile	NOUN
admet-2802	260	81	of	of	ADP
admet-2802	260	82	zwitterionic	zwitterionic	ADJ
admet-2802	260	83	drugs	drug	NOUN
admet-2802	260	84	.	.	PUNCT
admet-2802	261	1	the	the	DET
admet-2802	261	2	theoretical	theoretical	ADJ
admet-2802	261	3	equations	equation	NOUN
admet-2802	261	4	(	(	PUNCT
admet-2802	261	5	eqs	eqs	X
admet-2802	261	6	.	.	PUNCT
admet-2802	261	7	(	(	PUNCT
admet-2802	261	8	8)	8)	NUM
admet-2802	261	9	and	and	CCONJ
admet-2802	261	10	(	(	PUNCT
admet-2802	261	11	9	9	NUM
admet-2802	261	12	)	)	PUNCT
admet-2802	261	13	)	)	PUNCT
admet-2802	261	14	appropriately	appropriately	ADV
admet-2802	261	15	described	describe	VERB
admet-2802	261	16	the	the	DET
admet-2802	261	17	ph	ph	VERB
admet-2802	261	18	-	-	PUNCT
admet-2802	261	19	fu	fu	NOUN
admet-2802	261	20	profiles	profile	NOUN
admet-2802	261	21	.	.	PUNCT
admet-2802	262	1	the	the	DET
admet-2802	262	2	kbm	kbm	NOUN
admet-2802	262	3	,	,	PUNCT
admet-2802	262	4	z	z	NOUN
admet-2802	262	5	values	value	NOUN
admet-2802	262	6	are	be	AUX
admet-2802	262	7	summarized	summarize	VERB
admet-2802	262	8	in	in	ADP
admet-2802	262	9	table	table	NOUN
admet-2802	262	10	5	5	NUM
admet-2802	262	11	.	.	PUNCT
admet-2802	263	1	in	in	ADP
admet-2802	263	2	the	the	DET
admet-2802	263	3	case	case	NOUN
admet-2802	263	4	of	of	ADP
admet-2802	263	5	the	the	DET
admet-2802	263	6	zwitterionic	zwitterionic	ADJ
admet-2802	263	7	drugs	drug	NOUN
admet-2802	263	8	(	(	PUNCT
admet-2802	263	9	cetirizine	cetirizine	NOUN
admet-2802	263	10	and	and	CCONJ
admet-2802	263	11	olopatadine	olopatadine	NOUN
admet-2802	263	12	)	)	PUNCT
admet-2802	263	13	,	,	PUNCT
admet-2802	263	14	the	the	DET
admet-2802	263	15	anionic	anionic	NOUN
admet-2802	263	16	(	(	PUNCT
admet-2802	263	17	z	z	NOUN
admet-2802	263	18	=	=	SYM
admet-2802	263	19	-1	-1	ADJ
admet-2802	263	20	)	)	PUNCT
admet-2802	263	21	and	and	CCONJ
admet-2802	263	22	cationic	cationic	ADJ
admet-2802	263	23	(	(	PUNCT
admet-2802	263	24	z	z	NOUN
admet-2802	263	25	=	=	SYM
admet-2802	263	26	+1	+1	ADJ
admet-2802	263	27	)	)	PUNCT
admet-2802	263	28	species	specie	NOUN
admet-2802	263	29	were	be	AUX
admet-2802	263	30	bound	bind	VERB
admet-2802	263	31	to	to	PART
admet-2802	263	32	bile	bile	NOUN
admet-2802	263	33	micelles	micelle	NOUN
admet-2802	263	34	greater	great	ADJ
admet-2802	263	35	than	than	ADP
admet-2802	263	36	the	the	DET
admet-2802	263	37	zwitterionic	zwitterionic	ADJ
admet-2802	263	38	species	specie	NOUN
admet-2802	263	39	(	(	PUNCT
admet-2802	263	40	z	z	NOUN
admet-2802	263	41	=	=	SYM
admet-2802	263	42	±0	±0	NOUN
admet-2802	263	43	)	)	PUNCT
admet-2802	263	44	.	.	PUNCT
admet-2802	264	1	f	f	PROPN
admet-2802	264	2	u	u	NOUN
admet-2802	264	3	f	f	PROPN
admet-2802	264	4	u	u	PROPN
admet-2802	264	5	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	PROPN
admet-2802	264	6	m.	m.	NOUN
admet-2802	264	7	konishi	konishi	PROPN
admet-2802	264	8	and	and	CCONJ
admet-2802	264	9	k.	k.	PROPN
admet-2802	264	10	sugano	sugano	PROPN
admet-2802	264	11	admet	admet	PROPN
admet-2802	264	12	&	&	CCONJ
admet-2802	264	13	dmpk	dmpk	PROPN
admet-2802	264	14	13(4	13(4	NUM
admet-2802	264	15	)	)	PUNCT
admet-2802	264	16	(	(	PUNCT
admet-2802	264	17	2025	2025	NUM
admet-2802	264	18	)	)	PUNCT
admet-2802	264	19	2802	2802	NUM
admet-2802	264	20	8	8	NUM
admet-2802	264	21	figure	figure	NOUN
admet-2802	264	22	6	6	NUM
admet-2802	264	23	.	.	PUNCT
admet-2802	264	24	ph	ph	ADJ
admet-2802	264	25	-	-	PUNCT
admet-2802	264	26	fu	fu	ADJ
admet-2802	264	27	profile	profile	NOUN
admet-2802	264	28	of	of	ADP
admet-2802	264	29	zwitterionic	zwitterionic	ADJ
admet-2802	264	30	drugs	drug	NOUN
admet-2802	264	31	in	in	ADP
admet-2802	264	32	the	the	DET
admet-2802	264	33	tc	tc	PROPN
admet-2802	264	34	/	/	SYM
admet-2802	264	35	el	el	PROPN
admet-2802	264	36	bile	bile	NOUN
admet-2802	264	37	micelle	micelle	PROPN
admet-2802	264	38	medium	medium	NOUN
admet-2802	264	39	(	(	PUNCT
admet-2802	264	40	mean	mean	PROPN
admet-2802	264	41	±	±	NUM
admet-2802	264	42	sd	sd	NOUN
admet-2802	264	43	,	,	PUNCT
admet-2802	264	44	n	n	NOUN
admet-2802	264	45	=	=	SYM
admet-2802	264	46	3	3	NUM
admet-2802	264	47	)	)	PUNCT
admet-2802	264	48	.	.	PUNCT
admet-2802	265	1	the	the	DET
admet-2802	265	2	solid	solid	ADJ
admet-2802	265	3	line	line	NOUN
admet-2802	265	4	is	be	AUX
admet-2802	265	5	the	the	DET
admet-2802	265	6	fitted	fit	VERB
admet-2802	265	7	theoretical	theoretical	ADJ
admet-2802	265	8	curve	curve	NOUN
admet-2802	265	9	table	table	NOUN
admet-2802	265	10	5	5	NUM
admet-2802	265	11	.	.	PUNCT
admet-2802	266	1	kbm	kbm	NOUN
admet-2802	266	2	values	value	NOUN
admet-2802	266	3	of	of	ADP
admet-2802	266	4	zwitterionic	zwitterionic	ADJ
admet-2802	266	5	drugs	drug	NOUN
admet-2802	266	6	in	in	ADP
admet-2802	266	7	the	the	DET
admet-2802	266	8	tc	tc	PROPN
admet-2802	266	9	/	/	SYM
admet-2802	266	10	el	el	PROPN
admet-2802	266	11	bile	bile	NOUN
admet-2802	266	12	micelle	micelle	NOUN
admet-2802	266	13	media	medium	NOUN
admet-2802	266	14	(	(	PUNCT
admet-2802	266	15	mean	mean	PROPN
admet-2802	266	16	±	±	NUM
admet-2802	266	17	s.d	s.d	PROPN
admet-2802	266	18	.	.	PROPN
admet-2802	266	19	,	,	PUNCT
admet-2802	266	20	n	n	NOUN
admet-2802	266	21	=	=	SYM
admet-2802	266	22	3	3	X
admet-2802	266	23	)	)	PUNCT
admet-2802	266	24	drug	drug	NOUN
admet-2802	266	25	kbm,±0	kbm,±0	NOUN
admet-2802	266	26	kbm,-1	kbm,-1	PROPN
admet-2802	266	27	kbm,+1	kbm,+1	PROPN
admet-2802	266	28	kbm,-1	kbm,-1	PROPN
admet-2802	266	29	/	/	SYM
admet-2802	266	30	kbm,±0	kbm,±0	NOUN
admet-2802	266	31	kbm,+1	kbm,+1	NOUN
admet-2802	266	32	/	/	SYM
admet-2802	266	33	kbm,±0	kbm,±0	NOUN
admet-2802	266	34	cetirizinea	cetirizinea	VERB
admet-2802	266	35	5.34	5.34	NUM
admet-2802	266	36	±	±	NUM
admet-2802	266	37	0.33	0.33	NUM
admet-2802	266	38	×	×	NOUN
admet-2802	266	39	103	103	NUM
admet-2802	266	40	5.77	5.77	NUM
admet-2802	266	41	±	±	NUM
admet-2802	266	42	0.61	0.61	NUM
admet-2802	266	43	×	×	NOUN
admet-2802	266	44	103	103	NUM
admet-2802	266	45	2.09	2.09	NUM
admet-2802	266	46	±	±	NUM
admet-2802	266	47	0.10	0.10	NUM
admet-2802	266	48	×	×	NOUN
admet-2802	266	49	104	104	NUM
admet-2802	266	50	1.09	1.09	NUM
admet-2802	266	51	3.93	3.93	NUM
admet-2802	266	52	olopatadinea	olopatadinea	NOUN
admet-2802	266	53	5.47	5.47	NUM
admet-2802	266	54	±	±	NOUN
admet-2802	266	55	0.38	0.38	NUM
admet-2802	266	56	×	×	NOUN
admet-2802	266	57	102	102	NUM
admet-2802	266	58	1.26	1.26	NUM
admet-2802	266	59	±	±	NUM
admet-2802	266	60	0.15	0.15	NUM
admet-2802	266	61	×	×	NOUN
admet-2802	266	62	103	103	NUM
admet-2802	266	63	1.11	1.11	NUM
admet-2802	266	64	±	±	NUM
admet-2802	266	65	0.04	0.04	NUM
admet-2802	266	66	×	×	NOUN
admet-2802	266	67	104	104	NUM
admet-2802	266	68	2.33	2.33	NUM
admet-2802	266	69	20.5	20.5	NUM
admet-2802	266	70	a	a	DET
admet-2802	266	71	see	see	NOUN
admet-2802	266	72	text	text	NOUN
admet-2802	266	73	for	for	ADP
admet-2802	266	74	the	the	DET
admet-2802	266	75	explanation	explanation	NOUN
admet-2802	266	76	of	of	ADP
admet-2802	266	77	z	z	NOUN
admet-2802	266	78	=	=	PUNCT
admet-2802	266	79	±0	±0	NOUN
admet-2802	266	80	.	.	PUNCT
admet-2802	267	1	the	the	DET
admet-2802	267	2	equilibrium	equilibrium	NOUN
admet-2802	267	3	of	of	ADP
admet-2802	267	4	zwitterionic	zwitterionic	ADJ
admet-2802	267	5	drugs	drug	NOUN
admet-2802	267	6	is	be	AUX
admet-2802	267	7	expressed	express	VERB
admet-2802	267	8	by	by	ADP
admet-2802	267	9	equation	equation	NOUN
admet-2802	267	10	(	(	PUNCT
admet-2802	267	11	10	10	NUM
admet-2802	267	12	)	)	PUNCT
admet-2802	267	13	,	,	PUNCT
admet-2802	267	14	coohhn+	coohhn+	PROPN
admet-2802	267	15	coo-nh+	coo-nh+	PROPN
admet-2802	267	16	+	+	CCONJ
admet-2802	267	17	coohn	coohn	NOUN
admet-2802	267	18	coo-n	coo-n	PROPN
admet-2802	267	19	(	(	PUNCT
admet-2802	267	20	10	10	NUM
admet-2802	267	21	)	)	PUNCT
admet-2802	267	22	where	where	SCONJ
admet-2802	267	23	cooh	cooh	NOUN
admet-2802	267	24	is	be	AUX
admet-2802	267	25	a	a	DET
admet-2802	267	26	carboxylic	carboxylic	ADJ
admet-2802	267	27	group	group	NOUN
admet-2802	267	28	,	,	PUNCT
admet-2802	267	29	and	and	CCONJ
admet-2802	267	30	n	n	PRON
admet-2802	267	31	is	be	AUX
admet-2802	267	32	an	an	DET
admet-2802	267	33	amino	amino	NOUN
admet-2802	267	34	group	group	NOUN
admet-2802	267	35	.	.	PUNCT
admet-2802	268	1	in	in	ADP
admet-2802	268	2	the	the	DET
admet-2802	268	3	ph	ph	ADJ
admet-2802	268	4	region	region	NOUN
admet-2802	268	5	of	of	ADP
admet-2802	268	6	pka1	pka1	PROPN
admet-2802	268	7	(	(	PUNCT
admet-2802	268	8	acid	acid	PROPN
admet-2802	268	9	)	)	PUNCT
admet-2802	268	10	<	<	X
admet-2802	268	11	ph	ph	X
admet-2802	268	12	<	<	X
admet-2802	268	13	pka2	pka2	PROPN
admet-2802	268	14	(	(	PUNCT
admet-2802	268	15	base	base	NOUN
admet-2802	268	16	)	)	PUNCT
admet-2802	268	17	,	,	PUNCT
admet-2802	268	18	these	these	DET
admet-2802	268	19	drugs	drug	NOUN
admet-2802	268	20	can	can	AUX
admet-2802	268	21	exist	exist	VERB
admet-2802	268	22	as	as	ADP
admet-2802	268	23	un	un	ADJ
admet-2802	268	24	-	-	ADJ
admet-2802	268	25	ionized	ionized	ADJ
admet-2802	268	26	(	(	PUNCT
admet-2802	268	27	z	z	NOUN
admet-2802	268	28	=	=	SYM
admet-2802	268	29	0	0	NUM
admet-2802	268	30	,	,	PUNCT
admet-2802	268	31	cooh∙n	cooh∙n	NOUN
admet-2802	268	32	)	)	PUNCT
admet-2802	268	33	and	and	CCONJ
admet-2802	268	34	zwitterionic	zwitterionic	ADJ
admet-2802	268	35	species	specie	NOUN
admet-2802	268	36	(	(	PUNCT
admet-2802	268	37	z	z	NOUN
admet-2802	268	38	=	=	SYM
admet-2802	268	39	±0	±0	NOUN
admet-2802	268	40	,	,	PUNCT
admet-2802	268	41	coo-∙nh+	coo-∙nh+	NOUN
admet-2802	268	42	)	)	PUNCT
admet-2802	268	43	,	,	PUNCT
admet-2802	268	44	the	the	DET
admet-2802	268	45	latter	latter	ADJ
admet-2802	268	46	being	be	AUX
admet-2802	268	47	predominant	predominant	ADJ
admet-2802	269	1	[	[	X
admet-2802	269	2	30,31	30,31	NUM
admet-2802	269	3	]	]	PUNCT
admet-2802	269	4	.	.	PUNCT
admet-2802	270	1	the	the	DET
admet-2802	270	2	zwitterionic	zwitterionic	ADJ
admet-2802	270	3	form	form	NOUN
admet-2802	270	4	contains	contain	VERB
admet-2802	270	5	both	both	PRON
admet-2802	270	6	negative	negative	ADJ
admet-2802	270	7	(	(	PUNCT
admet-2802	270	8	z	z	NOUN
admet-2802	270	9	=	=	SYM
admet-2802	270	10	-1	-1	ADJ
admet-2802	270	11	)	)	PUNCT
admet-2802	270	12	and	and	CCONJ
admet-2802	270	13	positive	positive	ADJ
admet-2802	270	14	(	(	PUNCT
admet-2802	270	15	z	z	NOUN
admet-2802	270	16	=	=	SYM
admet-2802	270	17	+1	+1	ADJ
admet-2802	270	18	)	)	PUNCT
admet-2802	270	19	charge	charge	NOUN
admet-2802	270	20	moieties	moiety	NOUN
admet-2802	270	21	.	.	PUNCT
admet-2802	271	1	in	in	ADP
admet-2802	271	2	cetirizine	cetirizine	NOUN
admet-2802	271	3	and	and	CCONJ
admet-2802	271	4	olopatadine	olopatadine	NOUN
admet-2802	271	5	,	,	PUNCT
admet-2802	271	6	these	these	DET
admet-2802	271	7	two	two	NUM
admet-2802	271	8	moieties	moiety	NOUN
admet-2802	271	9	are	be	AUX
admet-2802	271	10	distant	distant	ADJ
admet-2802	271	11	from	from	ADP
admet-2802	271	12	each	each	DET
admet-2802	271	13	other	other	ADJ
admet-2802	271	14	and	and	CCONJ
admet-2802	271	15	not	not	PART
admet-2802	271	16	electrically	electrically	ADV
admet-2802	271	17	conjugated	conjugate	VERB
admet-2802	271	18	.	.	PUNCT
admet-2802	272	1	the	the	DET
admet-2802	272	2	negatively	negatively	ADV
admet-2802	272	3	charged	charge	VERB
admet-2802	272	4	moiety	moiety	NOUN
admet-2802	272	5	can	can	AUX
admet-2802	272	6	be	be	AUX
admet-2802	272	7	energetically	energetically	ADV
admet-2802	272	8	unfavourable	unfavourable	ADJ
admet-2802	272	9	for	for	ADP
admet-2802	272	10	partitioning	partition	VERB
admet-2802	272	11	to	to	ADP
admet-2802	272	12	both	both	CCONJ
admet-2802	272	13	the	the	DET
admet-2802	272	14	hydrophobic	hydrophobic	NOUN
admet-2802	272	15	core	core	NOUN
admet-2802	272	16	region	region	NOUN
admet-2802	272	17	and	and	CCONJ
admet-2802	272	18	the	the	DET
admet-2802	272	19	negatively	negatively	ADV
admet-2802	272	20	charged	charge	VERB
admet-2802	272	21	head	head	NOUN
admet-2802	272	22	group	group	NOUN
admet-2802	272	23	region	region	NOUN
admet-2802	272	24	of	of	ADP
admet-2802	272	25	the	the	DET
admet-2802	272	26	bile	bile	NOUN
admet-2802	272	27	micelle	micelle	NOUN
admet-2802	272	28	.	.	PUNCT
admet-2802	273	1	on	on	ADP
admet-2802	273	2	the	the	DET
admet-2802	273	3	other	other	ADJ
admet-2802	273	4	hand	hand	NOUN
admet-2802	273	5	,	,	PUNCT
admet-2802	273	6	the	the	DET
admet-2802	273	7	positively	positively	ADV
admet-2802	273	8	charged	charge	VERB
admet-2802	273	9	moiety	moiety	NOUN
admet-2802	273	10	can	can	AUX
admet-2802	273	11	be	be	AUX
admet-2802	273	12	energetically	energetically	ADV
admet-2802	273	13	unfavourable	unfavourable	ADJ
admet-2802	273	14	for	for	ADP
admet-2802	273	15	partitioning	partition	VERB
admet-2802	273	16	to	to	ADP
admet-2802	273	17	the	the	DET
admet-2802	273	18	hydrophobic	hydrophobic	NOUN
admet-2802	273	19	core	core	NOUN
admet-2802	273	20	region	region	NOUN
admet-2802	273	21	;	;	PUNCT
admet-2802	273	22	however	however	ADV
admet-2802	273	23	,	,	PUNCT
admet-2802	273	24	favourable	favourable	ADJ
admet-2802	273	25	for	for	ADP
admet-2802	273	26	partitioning	partition	VERB
admet-2802	273	27	to	to	ADP
admet-2802	273	28	the	the	DET
admet-2802	273	29	negatively	negatively	ADV
admet-2802	273	30	charged	charge	VERB
admet-2802	273	31	head	head	NOUN
admet-2802	273	32	group	group	NOUN
admet-2802	273	33	region	region	NOUN
admet-2802	273	34	.	.	PUNCT
admet-2802	274	1	the	the	DET
admet-2802	274	2	balance	balance	NOUN
admet-2802	274	3	of	of	ADP
admet-2802	274	4	these	these	DET
admet-2802	274	5	factors	factor	NOUN
admet-2802	274	6	determines	determine	VERB
admet-2802	274	7	the	the	DET
admet-2802	274	8	kbm	kbm	NOUN
admet-2802	274	9	,	,	PUNCT
admet-2802	274	10	z/	z/	NOUN
admet-2802	274	11	kbm,±0	kbm,±0	NOUN
admet-2802	274	12	value	value	NOUN
admet-2802	274	13	.	.	PUNCT
admet-2802	275	1	kbm,+1	kbm,+1	NOUN
admet-2802	275	2	/	/	SYM
admet-2802	275	3	kbm,±0	kbm,±0	NOUN
admet-2802	275	4	was	be	AUX
admet-2802	275	5	3.9	3.9	NUM
admet-2802	275	6	and	and	CCONJ
admet-2802	275	7	20	20	NUM
admet-2802	275	8	for	for	ADP
admet-2802	275	9	cetirizine	cetirizine	NOUN
admet-2802	275	10	and	and	CCONJ
admet-2802	275	11	olopatadine	olopatadine	NOUN
admet-2802	275	12	,	,	PUNCT
admet-2802	275	13	respectively	respectively	ADV
admet-2802	275	14	(	(	PUNCT
admet-2802	275	15	table	table	NOUN
admet-2802	275	16	4	4	NUM
admet-2802	275	17	)	)	PUNCT
admet-2802	275	18	.	.	PUNCT
admet-2802	276	1	these	these	DET
admet-2802	276	2	values	value	NOUN
admet-2802	276	3	are	be	AUX
admet-2802	276	4	greater	great	ADJ
admet-2802	276	5	than	than	ADP
admet-2802	276	6	the	the	DET
admet-2802	276	7	kbm,+1	kbm,+1	PROPN
admet-2802	276	8	/	/	SYM
admet-2802	276	9	kbm,0	kbm,0	ADJ
admet-2802	276	10	value	value	NOUN
admet-2802	276	11	for	for	ADP
admet-2802	276	12	monovalent	monovalent	NOUN
admet-2802	276	13	weak	weak	ADJ
admet-2802	276	14	base	base	NOUN
admet-2802	276	15	drugs	drug	NOUN
admet-2802	276	16	(	(	PUNCT
admet-2802	276	17	0.24	0.24	NUM
admet-2802	276	18	to	to	ADP
admet-2802	276	19	2.6	2.6	NUM
admet-2802	276	20	)	)	PUNCT
admet-2802	276	21	.	.	PUNCT
admet-2802	277	1	when	when	SCONJ
admet-2802	277	2	changing	change	VERB
admet-2802	277	3	ph	ph	NOUN
admet-2802	277	4	from	from	ADP
admet-2802	277	5	ph	ph	PROPN
admet-2802	277	6	<	<	X
admet-2802	277	7	pka1	pka1	PROPN
admet-2802	277	8	to	to	PART
admet-2802	277	9	ph	ph	PROPN
admet-2802	277	10	>	>	X
admet-2802	277	11	pka1	pka1	PROPN
admet-2802	277	12	,	,	PUNCT
admet-2802	277	13	a	a	DET
admet-2802	277	14	negative	negative	ADJ
admet-2802	277	15	charge	charge	NOUN
admet-2802	277	16	is	be	AUX
admet-2802	277	17	added	add	VERB
admet-2802	277	18	to	to	ADP
admet-2802	277	19	the	the	DET
admet-2802	277	20	cationic	cationic	ADJ
admet-2802	277	21	species	specie	NOUN
admet-2802	277	22	.	.	PUNCT
admet-2802	278	1	(	(	PUNCT
admet-2802	278	2	i.e.	i.e.	X
admet-2802	278	3	z	z	X
admet-2802	278	4	=	=	SYM
admet-2802	278	5	+1	+1	PROPN
admet-2802	278	6	+	+	CCONJ
admet-2802	278	7	(	(	PUNCT
admet-2802	278	8	-1	-1	INTJ
admet-2802	278	9	)	)	PUNCT
admet-2802	278	10	=	=	PUNCT
admet-2802	278	11	±0	±0	NOUN
admet-2802	278	12	)	)	PUNCT
admet-2802	278	13	.	.	PUNCT
admet-2802	279	1	the	the	DET
admet-2802	279	2	large	large	ADJ
admet-2802	279	3	kbm,+1	kbm,+1	NOUN
admet-2802	279	4	/	/	SYM
admet-2802	279	5	kbm,±0	kbm,±0	NOUN
admet-2802	279	6	values	value	NOUN
admet-2802	279	7	suggested	suggest	VERB
admet-2802	279	8	that	that	SCONJ
admet-2802	279	9	the	the	DET
admet-2802	279	10	addition	addition	NOUN
admet-2802	279	11	of	of	ADP
admet-2802	279	12	a	a	DET
admet-2802	279	13	negative	negative	ADJ
admet-2802	279	14	charge	charge	NOUN
admet-2802	279	15	is	be	AUX
admet-2802	279	16	markedly	markedly	ADV
admet-2802	279	17	unfavourable	unfavourable	ADJ
admet-2802	279	18	for	for	SCONJ
admet-2802	279	19	the	the	DET
admet-2802	279	20	bile	bile	NOUN
admet-2802	279	21	micelle	micelle	NOUN
admet-2802	279	22	partitioning	partition	VERB
admet-2802	279	23	,	,	PUNCT
admet-2802	279	24	like	like	ADP
admet-2802	279	25	the	the	DET
admet-2802	279	26	cases	case	NOUN
admet-2802	279	27	of	of	ADP
admet-2802	279	28	monovalent	monovalent	NOUN
admet-2802	279	29	weak	weak	ADJ
admet-2802	279	30	acids	acid	NOUN
admet-2802	279	31	.	.	PUNCT
admet-2802	280	1	kbm,+1/	kbm,+1/	NOUN
admet-2802	280	2	kbm,±0	kbm,±0	NOUN
admet-2802	280	3	can	can	AUX
admet-2802	280	4	be	be	AUX
admet-2802	280	5	rearranged	rearrange	VERB
admet-2802	280	6	as	as	ADP
admet-2802	280	7	equation	equation	NOUN
admet-2802	280	8	(	(	PUNCT
admet-2802	280	9	11	11	NUM
admet-2802	280	10	)	)	PUNCT
admet-2802	280	11	bm,+1	bm,+1	ADV
admet-2802	281	1	bm,+1	bm,+1	PROPN
admet-2802	281	2	bm,0	bm,0	PROPN
admet-2802	281	3	bm,±0	bm,±0	ADJ
admet-2802	281	4	bm,0	bm,0	PROPN
admet-2802	281	5	bm,±0	bm,±0	NOUN
admet-2802	282	1	k	k	PROPN
admet-2802	282	2	k	k	PROPN
admet-2802	283	1	k	k	PROPN
admet-2802	283	2	k	k	PROPN
admet-2802	284	1	k	k	PROPN
admet-2802	284	2	k	k	PROPN
admet-2802	285	1	=	=	PUNCT
admet-2802	286	1	(	(	PUNCT
admet-2802	286	2	11	11	NUM
admet-2802	286	3	)	)	PUNCT
admet-2802	286	4	therefore	therefore	ADV
admet-2802	286	5	,	,	PUNCT
admet-2802	286	6	equation	equation	NOUN
admet-2802	286	7	(	(	PUNCT
admet-2802	286	8	12	12	NUM
admet-2802	286	9	)	)	PUNCT
admet-2802	286	10	bm,0	bm,0	PROPN
admet-2802	286	11	bm,+1	bm,+1	PROPN
admet-2802	286	12	bm,±0	bm,±0	NOUN
admet-2802	286	13	bm,±0	bm,±0	NOUN
admet-2802	286	14	bm,0	bm,0	PROPN
admet-2802	287	1	bm,+1	bm,+1	PROPN
admet-2802	287	2	k	k	PROPN
admet-2802	288	1	k	k	PROPN
admet-2802	289	1	k	k	PROPN
admet-2802	290	1	k	k	PROPN
admet-2802	290	2	k	k	PROPN
admet-2802	291	1	k	k	PROPN
admet-2802	291	2	=	=	PUNCT
admet-2802	291	3	(	(	PUNCT
admet-2802	291	4	12	12	NUM
admet-2802	291	5	)	)	PUNCT
admet-2802	291	6	if	if	SCONJ
admet-2802	291	7	the	the	DET
admet-2802	291	8	average	average	ADJ
admet-2802	291	9	kbm,+1	kbm,+1	NOUN
admet-2802	291	10	/	/	SYM
admet-2802	291	11	kbm,0	kbm,0	ADJ
admet-2802	291	12	value	value	NOUN
admet-2802	291	13	for	for	ADP
admet-2802	291	14	monovalent	monovalent	NOUN
admet-2802	291	15	weak	weak	ADJ
admet-2802	291	16	base	base	NOUN
admet-2802	291	17	drugs	drug	NOUN
admet-2802	291	18	(	(	PUNCT
admet-2802	291	19	0.81	0.81	NUM
admet-2802	291	20	)	)	PUNCT
admet-2802	291	21	is	be	AUX
admet-2802	291	22	applied	apply	VERB
admet-2802	291	23	to	to	ADP
admet-2802	291	24	eq	eq	PROPN
admet-2802	291	25	.	.	PROPN
admet-2802	291	26	12	12	NUM
admet-2802	291	27	,	,	PUNCT
admet-2802	291	28	kbm,0	kbm,0	PROPN
admet-2802	291	29	/	/	SYM
admet-2802	291	30	kbm,±0	kbm,±0	NOUN
admet-2802	291	31	becomes	become	VERB
admet-2802	291	32	0.21	0.21	NUM
admet-2802	291	33	and	and	CCONJ
admet-2802	291	34	0.041	0.041	NUM
admet-2802	291	35	for	for	ADP
admet-2802	291	36	cetirizine	cetirizine	NOUN
admet-2802	291	37	and	and	CCONJ
admet-2802	291	38	olopatadine	olopatadine	NOUN
admet-2802	291	39	,	,	PUNCT
admet-2802	291	40	respectively	respectively	ADV
admet-2802	291	41	.	.	PUNCT
admet-2802	292	1	this	this	PRON
admet-2802	292	2	may	may	AUX
admet-2802	292	3	suggest	suggest	VERB
admet-2802	292	4	that	that	SCONJ
admet-2802	292	5	,	,	PUNCT
admet-2802	292	6	for	for	SCONJ
admet-2802	292	7	bile	bile	NOUN
admet-2802	292	8	micelle	micelle	NOUN
admet-2802	292	9	binding	bind	VERB
admet-2802	292	10	,	,	PUNCT
admet-2802	292	11	the	the	DET
admet-2802	292	12	zwitterionic	zwitterionic	ADJ
admet-2802	292	13	species	specie	NOUN
admet-2802	292	14	(	(	PUNCT
admet-2802	292	15	z	z	NOUN
admet-2802	292	16	=	=	SYM
admet-2802	292	17	±0	±0	NOUN
admet-2802	292	18	,	,	PUNCT
admet-2802	292	19	coo	coo	NOUN
admet-2802	292	20	--	--	PUNCT
admet-2802	292	21	nh+	nh+	NOUN
admet-2802	292	22	)	)	PUNCT
admet-2802	292	23	is	be	AUX
admet-2802	292	24	significantly	significantly	ADV
admet-2802	292	25	less	less	ADV
admet-2802	292	26	favourable	favourable	ADJ
admet-2802	292	27	than	than	ADP
admet-2802	292	28	the	the	DET
admet-2802	292	29	un	un	ADJ
admet-2802	292	30	-	-	ADJ
admet-2802	292	31	ionized	ionized	ADJ
admet-2802	292	32	species	specie	NOUN
admet-2802	292	33	(	(	PUNCT
admet-2802	292	34	z	z	NOUN
admet-2802	292	35	=	=	SYM
admet-2802	292	36	0	0	NUM
admet-2802	292	37	,	,	PUNCT
admet-2802	292	38	cooh	cooh	NOUN
admet-2802	292	39	-	-	PUNCT
admet-2802	292	40	n	n	CCONJ
admet-2802	292	41	)	)	PUNCT
admet-2802	292	42	.	.	PUNCT
admet-2802	293	1	however	however	ADV
admet-2802	293	2	,	,	PUNCT
admet-2802	293	3	a	a	DET
admet-2802	293	4	more	more	ADV
admet-2802	293	5	detailed	detailed	ADJ
admet-2802	293	6	investigation	investigation	NOUN
admet-2802	293	7	is	be	AUX
admet-2802	293	8	required	require	VERB
admet-2802	293	9	to	to	PART
admet-2802	293	10	conclude	conclude	VERB
admet-2802	293	11	this	this	DET
admet-2802	293	12	point	point	NOUN
admet-2802	293	13	[	[	X
admet-2802	293	14	13	13	NUM
admet-2802	293	15	]	]	PUNCT
admet-2802	293	16	.	.	PUNCT
admet-2802	294	1	the	the	DET
admet-2802	294	2	kbm,-1	kbm,-1	PROPN
admet-2802	294	3	/	/	SYM
admet-2802	294	4	kbm,±0	kbm,±0	NOUN
admet-2802	294	5	ratios	ratio	NOUN
admet-2802	294	6	were	be	AUX
admet-2802	294	7	also	also	ADV
admet-2802	294	8	greater	great	ADJ
admet-2802	294	9	than	than	ADP
admet-2802	294	10	1.0	1.0	NUM
admet-2802	294	11	(	(	PUNCT
admet-2802	294	12	1.1	1.1	NUM
admet-2802	294	13	and	and	CCONJ
admet-2802	294	14	2.3	2.3	NUM
admet-2802	294	15	for	for	ADP
admet-2802	294	16	cetirizine	cetirizine	NOUN
admet-2802	294	17	and	and	CCONJ
admet-2802	294	18	olopatadine	olopatadine	NOUN
admet-2802	294	19	,	,	PUNCT
admet-2802	294	20	respectively	respectively	ADV
admet-2802	294	21	)	)	PUNCT
admet-2802	294	22	.	.	PUNCT
admet-2802	295	1	the	the	DET
admet-2802	295	2	removal	removal	NOUN
admet-2802	295	3	of	of	ADP
admet-2802	295	4	one	one	NUM
admet-2802	295	5	positive	positive	ADJ
admet-2802	295	6	charge	charge	NOUN
admet-2802	295	7	from	from	ADP
admet-2802	295	8	the	the	DET
admet-2802	295	9	zwitterion	zwitterion	NOUN
admet-2802	295	10	(	(	PUNCT
admet-2802	295	11	i.e.	i.e.	X
admet-2802	295	12	z	z	NOUN
admet-2802	295	13	=	=	SYM
admet-2802	295	14	±0	±0	ADJ
admet-2802	295	15	(	(	PUNCT
admet-2802	295	16	+	+	NOUN
admet-2802	295	17	1	1	X
admet-2802	295	18	)	)	PUNCT
admet-2802	295	19	=	=	NOUN
admet-2802	295	20	-1	-1	VERB
admet-2802	295	21	)	)	PUNCT
admet-2802	295	22	by	by	ADP
admet-2802	295	23	changing	change	VERB
admet-2802	295	24	ph	ph	NOUN
admet-2802	295	25	from	from	ADP
admet-2802	295	26	ph	ph	PROPN
admet-2802	295	27	<	<	X
admet-2802	295	28	pka2	pka2	NOUN
admet-2802	295	29	to	to	ADP
admet-2802	295	30	f	f	PROPN
admet-2802	295	31	u	u	PROPN
admet-2802	295	32	f	f	PROPN
admet-2802	295	33	u	u	PROPN
admet-2802	295	34	admet	admet	X
admet-2802	295	35	&	&	CCONJ
admet-2802	295	36	dmpk	dmpk	PROPN
admet-2802	295	37	13(4	13(4	NUM
admet-2802	295	38	)	)	PUNCT
admet-2802	295	39	(	(	PUNCT
admet-2802	295	40	2025	2025	NUM
admet-2802	295	41	)	)	PUNCT
admet-2802	295	42	2802	2802	NUM
admet-2802	295	43	bile	bile	NOUN
admet-2802	295	44	micelle	micelle	NOUN
admet-2802	295	45	binding	bind	VERB
admet-2802	295	46	of	of	ADP
admet-2802	295	47	structurally	structurally	ADV
admet-2802	295	48	diverse	diverse	ADJ
admet-2802	295	49	ionized	ionized	ADJ
admet-2802	295	50	drugs	drug	NOUN
admet-2802	295	51	doi	doi	NOUN
admet-2802	295	52	:	:	PUNCT
admet-2802	295	53	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	295	54	9	9	NUM
admet-2802	295	55	ph	ph	NOUN
admet-2802	295	56	>	>	X
admet-2802	295	57	pka2	pka2	PROPN
admet-2802	295	58	increased	increase	VERB
admet-2802	295	59	the	the	DET
admet-2802	295	60	bile	bile	NOUN
admet-2802	295	61	micelle	micelle	NOUN
admet-2802	295	62	partitioning	partition	VERB
admet-2802	295	63	for	for	ADP
admet-2802	295	64	these	these	DET
admet-2802	295	65	drugs	drug	NOUN
admet-2802	295	66	.	.	PUNCT
admet-2802	296	1	as	as	SCONJ
admet-2802	296	2	discussed	discuss	VERB
admet-2802	296	3	above	above	ADV
admet-2802	296	4	,	,	PUNCT
admet-2802	296	5	the	the	DET
admet-2802	296	6	removal	removal	NOUN
admet-2802	296	7	of	of	ADP
admet-2802	296	8	a	a	DET
admet-2802	296	9	positive	positive	ADJ
admet-2802	296	10	charge	charge	NOUN
admet-2802	296	11	from	from	ADP
admet-2802	296	12	a	a	DET
admet-2802	296	13	drug	drug	NOUN
admet-2802	296	14	can	can	AUX
admet-2802	296	15	be	be	AUX
admet-2802	296	16	both	both	CCONJ
admet-2802	296	17	favourable	favourable	ADJ
admet-2802	296	18	and	and	CCONJ
admet-2802	296	19	unfavourable	unfavourable	ADJ
admet-2802	296	20	for	for	ADP
admet-2802	296	21	bile	bile	NOUN
admet-2802	296	22	micelle	micelle	NOUN
admet-2802	296	23	partitioning	partition	VERB
admet-2802	296	24	,	,	PUNCT
admet-2802	296	25	in	in	ADP
admet-2802	296	26	this	this	DET
admet-2802	296	27	case	case	NOUN
admet-2802	296	28	,	,	PUNCT
admet-2802	296	29	favourable	favourable	ADJ
admet-2802	296	30	.	.	PUNCT
admet-2802	297	1	relationship	relationship	NOUN
admet-2802	297	2	between	between	ADP
admet-2802	297	3	kbm,0	kbm,0	PROPN
admet-2802	297	4	and	and	CCONJ
admet-2802	297	5	poct	poct	PROPN
admet-2802	297	6	previously	previously	ADV
admet-2802	297	7	,	,	PUNCT
admet-2802	297	8	glomme	glomme	PROPN
admet-2802	297	9	et	et	PROPN
admet-2802	297	10	al	al	PROPN
admet-2802	297	11	.	.	PUNCT
admet-2802	298	1	[	[	X
admet-2802	298	2	11	11	NUM
admet-2802	298	3	]	]	PUNCT
admet-2802	298	4	reported	report	VERB
admet-2802	298	5	a	a	DET
admet-2802	298	6	good	good	ADJ
admet-2802	298	7	correlation	correlation	NOUN
admet-2802	298	8	between	between	ADP
admet-2802	298	9	kbm,0	kbm,0	PROPN
admet-2802	298	10	and	and	CCONJ
admet-2802	298	11	poct,0	poct,0	NOUN
admet-2802	298	12	(	(	PUNCT
admet-2802	298	13	logkbm,0	logkbm,0	ADJ
admet-2802	298	14	=	=	SYM
admet-2802	298	15	0.74	0.74	NUM
admet-2802	298	16	logpoct,0	logpoct,0	NOUN
admet-2802	299	1	+	+	X
admet-2802	299	2	+	+	NUM
admet-2802	299	3	2.29	2.29	NUM
admet-2802	299	4	)	)	PUNCT
admet-2802	299	5	.	.	PUNCT
admet-2802	300	1	in	in	ADP
admet-2802	300	2	that	that	DET
admet-2802	300	3	study	study	NOUN
admet-2802	300	4	,	,	PUNCT
admet-2802	300	5	kbm,0	kbm,0	PROPN
admet-2802	300	6	was	be	AUX
admet-2802	300	7	obtained	obtain	VERB
admet-2802	300	8	from	from	ADP
admet-2802	300	9	the	the	DET
admet-2802	300	10	solubility	solubility	NOUN
admet-2802	300	11	data	datum	NOUN
admet-2802	300	12	in	in	ADP
admet-2802	300	13	bile	bile	NOUN
admet-2802	300	14	micelle	micelle	NOUN
admet-2802	300	15	media	medium	NOUN
admet-2802	300	16	for	for	ADP
admet-2802	300	17	poorly	poorly	ADV
admet-2802	300	18	soluble	soluble	ADJ
admet-2802	300	19	unionizable	unionizable	ADJ
admet-2802	300	20	drugs	drug	NOUN
admet-2802	300	21	.	.	PUNCT
admet-2802	301	1	however	however	ADV
admet-2802	301	2	,	,	PUNCT
admet-2802	301	3	in	in	ADP
admet-2802	301	4	the	the	DET
admet-2802	301	5	present	present	ADJ
admet-2802	301	6	study	study	NOUN
admet-2802	301	7	,	,	PUNCT
admet-2802	301	8	only	only	ADV
admet-2802	301	9	a	a	DET
admet-2802	301	10	poor	poor	ADJ
admet-2802	301	11	correlation	correlation	NOUN
admet-2802	301	12	was	be	AUX
admet-2802	301	13	found	find	VERB
admet-2802	301	14	between	between	ADP
admet-2802	301	15	kbm,0	kbm,0	PROPN
admet-2802	301	16	and	and	CCONJ
admet-2802	301	17	poct,0	poct,0	NOUN
admet-2802	301	18	(	(	PUNCT
admet-2802	301	19	logkbm,0	logkbm,0	ADJ
admet-2802	301	20	=	=	SYM
admet-2802	301	21	0.62	0.62	NUM
admet-2802	301	22	logpoct,0	logpoct,0	NOUN
admet-2802	301	23	+	+	NUM
admet-2802	301	24	1.55	1.55	NUM
admet-2802	301	25	,	,	PUNCT
admet-2802	301	26	r	r	NOUN
admet-2802	301	27	=	=	SYM
admet-2802	301	28	0.68	0.68	NUM
admet-2802	301	29	)	)	PUNCT
admet-2802	301	30	(	(	PUNCT
admet-2802	301	31	figure	figure	VERB
admet-2802	301	32	7	7	NUM
admet-2802	301	33	)	)	PUNCT
admet-2802	301	34	.	.	PUNCT
admet-2802	302	1	the	the	DET
admet-2802	302	2	slope	slope	NOUN
admet-2802	302	3	and	and	CCONJ
admet-2802	302	4	intercept	intercept	NOUN
admet-2802	302	5	deviated	deviate	VERB
admet-2802	302	6	from	from	ADP
admet-2802	302	7	the	the	DET
admet-2802	302	8	previous	previous	ADJ
admet-2802	302	9	report	report	NOUN
admet-2802	302	10	.	.	PUNCT
admet-2802	303	1	the	the	DET
admet-2802	303	2	reason	reason	NOUN
admet-2802	303	3	for	for	ADP
admet-2802	303	4	this	this	DET
admet-2802	303	5	discrepancy	discrepancy	NOUN
admet-2802	303	6	is	be	AUX
admet-2802	303	7	not	not	PART
admet-2802	303	8	clear	clear	ADJ
admet-2802	303	9	.	.	PUNCT
admet-2802	304	1	for	for	ADP
admet-2802	304	2	high	high	ADJ
admet-2802	304	3	solubility	solubility	NOUN
admet-2802	304	4	drugs	drug	NOUN
admet-2802	304	5	,	,	PUNCT
admet-2802	304	6	it	it	PRON
admet-2802	304	7	is	be	AUX
admet-2802	304	8	difficult	difficult	ADJ
admet-2802	304	9	to	to	PART
admet-2802	304	10	measure	measure	VERB
admet-2802	304	11	fu	fu	NOUN
admet-2802	304	12	from	from	ADP
admet-2802	304	13	the	the	DET
admet-2802	304	14	solubility	solubility	NOUN
admet-2802	304	15	values	value	NOUN
admet-2802	304	16	in	in	ADP
admet-2802	304	17	bile	bile	NOUN
admet-2802	304	18	micelle	micelle	NOUN
admet-2802	304	19	media	medium	NOUN
admet-2802	304	20	.	.	PUNCT
admet-2802	305	1	therefore	therefore	ADV
admet-2802	305	2	,	,	PUNCT
admet-2802	305	3	dynamic	dynamic	ADJ
admet-2802	305	4	dialysis	dialysis	NOUN
admet-2802	305	5	was	be	AUX
admet-2802	305	6	used	use	VERB
admet-2802	305	7	in	in	ADP
admet-2802	305	8	the	the	DET
admet-2802	305	9	present	present	ADJ
admet-2802	305	10	study	study	NOUN
admet-2802	305	11	.	.	PUNCT
admet-2802	306	1	this	this	PRON
admet-2802	306	2	might	might	AUX
admet-2802	306	3	be	be	AUX
admet-2802	306	4	one	one	NUM
admet-2802	306	5	of	of	ADP
admet-2802	306	6	the	the	DET
admet-2802	306	7	reasons	reason	NOUN
admet-2802	306	8	for	for	ADP
admet-2802	306	9	the	the	DET
admet-2802	306	10	discrepancy	discrepancy	NOUN
admet-2802	306	11	.	.	PUNCT
admet-2802	307	1	log	log	VERB
admet-2802	307	2	poct	poct	NOUN
admet-2802	307	3	figure	figure	NOUN
admet-2802	307	4	7	7	NUM
admet-2802	307	5	.	.	PUNCT
admet-2802	307	6	correlation	correlation	NOUN
admet-2802	307	7	between	between	ADP
admet-2802	307	8	log	log	NOUN
admet-2802	307	9	poct,0	poct,0	NOUN
admet-2802	307	10	and	and	CCONJ
admet-2802	307	11	log	log	VERB
admet-2802	307	12	kbm,0	kbm,0	PROPN
admet-2802	307	13	for	for	ADP
admet-2802	307	14	tc	tc	PROPN
admet-2802	307	15	/	/	SYM
admet-2802	307	16	el	el	PROPN
admet-2802	307	17	bile	bile	NOUN
admet-2802	307	18	micelles	micelle	NOUN
admet-2802	307	19	.	.	PUNCT
admet-2802	308	1	solid	solid	ADJ
admet-2802	308	2	line	line	NOUN
admet-2802	308	3	:	:	PUNCT
admet-2802	308	4	the	the	DET
admet-2802	308	5	fitted	fit	VERB
admet-2802	308	6	line	line	NOUN
admet-2802	308	7	in	in	ADP
admet-2802	308	8	this	this	DET
admet-2802	308	9	study	study	NOUN
admet-2802	308	10	,	,	PUNCT
admet-2802	308	11	dotted	dotted	ADJ
admet-2802	308	12	line	line	NOUN
admet-2802	308	13	:	:	PUNCT
admet-2802	308	14	the	the	DET
admet-2802	308	15	correlation	correlation	NOUN
admet-2802	308	16	line	line	NOUN
admet-2802	308	17	previously	previously	ADV
admet-2802	308	18	reported	report	VERB
admet-2802	308	19	by	by	ADP
admet-2802	308	20	glomme	glomme	PROPN
admet-2802	308	21	et	et	PROPN
admet-2802	308	22	al	al	PROPN
admet-2802	308	23	.	.	PUNCT
admet-2802	309	1	[	[	X
admet-2802	309	2	11	11	NUM
admet-2802	309	3	]	]	SYM
admet-2802	309	4	suggestions	suggestion	NOUN
admet-2802	309	5	for	for	ADP
admet-2802	309	6	food	food	NOUN
admet-2802	309	7	effect	effect	NOUN
admet-2802	309	8	prediction	prediction	NOUN
admet-2802	309	9	by	by	ADP
admet-2802	309	10	pbbm	pbbm	PRON
admet-2802	309	11	the	the	DET
admet-2802	309	12	results	result	NOUN
admet-2802	309	13	of	of	ADP
admet-2802	309	14	this	this	DET
admet-2802	309	15	study	study	NOUN
admet-2802	309	16	suggested	suggest	VERB
admet-2802	309	17	that	that	SCONJ
admet-2802	309	18	,	,	PUNCT
admet-2802	309	19	when	when	SCONJ
admet-2802	309	20	predicting	predict	VERB
admet-2802	309	21	the	the	DET
admet-2802	309	22	food	food	NOUN
admet-2802	309	23	effect	effect	NOUN
admet-2802	309	24	for	for	ADP
admet-2802	309	25	highly	highly	ADV
admet-2802	309	26	soluble	soluble	ADJ
admet-2802	309	27	weak	weak	ADJ
admet-2802	309	28	acid	acid	NOUN
admet-2802	309	29	drugs	drug	NOUN
admet-2802	309	30	,	,	PUNCT
admet-2802	309	31	kbm,-1	kbm,-1	PROPN
admet-2802	309	32	can	can	AUX
admet-2802	309	33	be	be	AUX
admet-2802	309	34	negligible	negligible	ADJ
admet-2802	309	35	.	.	PUNCT
admet-2802	310	1	in	in	ADP
admet-2802	310	2	contrast	contrast	NOUN
admet-2802	310	3	,	,	PUNCT
admet-2802	310	4	for	for	ADP
admet-2802	310	5	highly	highly	ADV
admet-2802	310	6	soluble	soluble	ADJ
admet-2802	310	7	weak	weak	ADJ
admet-2802	310	8	base	base	NOUN
admet-2802	310	9	drugs	drug	NOUN
admet-2802	310	10	,	,	PUNCT
admet-2802	310	11	kbm,+1	kbm,+1	PROPN
admet-2802	310	12	should	should	AUX
admet-2802	310	13	be	be	AUX
admet-2802	310	14	considered	consider	VERB
admet-2802	310	15	.	.	PUNCT
admet-2802	311	1	it	it	PRON
admet-2802	311	2	was	be	AUX
admet-2802	311	3	previously	previously	ADV
admet-2802	311	4	reported	report	VERB
admet-2802	311	5	that	that	SCONJ
admet-2802	311	6	the	the	DET
admet-2802	311	7	fu	fu	PROPN
admet-2802	311	8	value	value	NOUN
admet-2802	311	9	at	at	ADP
admet-2802	311	10	ph	ph	PROPN
admet-2802	311	11	6.5	6.5	NUM
admet-2802	311	12	correlated	correlate	VERB
admet-2802	311	13	with	with	ADP
admet-2802	311	14	the	the	DET
admet-2802	311	15	clinical	clinical	ADJ
admet-2802	311	16	negative	negative	ADJ
admet-2802	311	17	food	food	NOUN
admet-2802	311	18	effect	effect	NOUN
admet-2802	311	19	for	for	ADP
admet-2802	311	20	high	high	ADJ
admet-2802	311	21	solubility	solubility	NOUN
admet-2802	311	22	weak	weak	ADJ
admet-2802	311	23	base	base	NOUN
admet-2802	311	24	drugs	drug	NOUN
admet-2802	311	25	[	[	X
admet-2802	311	26	4	4	NUM
admet-2802	311	27	]	]	PUNCT
admet-2802	311	28	.	.	PUNCT
admet-2802	312	1	at	at	ADP
admet-2802	312	2	ph	ph	PROPN
admet-2802	312	3	6.5	6.5	NUM
admet-2802	312	4	,	,	PUNCT
admet-2802	312	5	a	a	DET
admet-2802	312	6	weak	weak	ADJ
admet-2802	312	7	base	base	NOUN
admet-2802	312	8	drug	drug	NOUN
admet-2802	312	9	with	with	ADP
admet-2802	312	10	pka	pka	PROPN
admet-2802	312	11	>	>	X
admet-2802	312	12	7.5	7.5	NUM
admet-2802	312	13	mainly	mainly	ADV
admet-2802	312	14	exists	exist	VERB
admet-2802	312	15	as	as	ADP
admet-2802	312	16	cationic	cationic	ADJ
admet-2802	312	17	species	specie	NOUN
admet-2802	312	18	(	(	PUNCT
admet-2802	312	19	>	>	X
admet-2802	312	20	90	90	NUM
admet-2802	312	21	%	%	NOUN
admet-2802	312	22	)	)	PUNCT
admet-2802	312	23	.	.	PUNCT
admet-2802	313	1	it	it	PRON
admet-2802	313	2	was	be	AUX
admet-2802	313	3	recently	recently	ADV
admet-2802	313	4	reported	report	VERB
admet-2802	313	5	that	that	SCONJ
admet-2802	313	6	quaternary	quaternary	ADJ
admet-2802	313	7	ammonium	ammonium	NOUN
admet-2802	313	8	compounds	compound	NOUN
admet-2802	313	9	(	(	PUNCT
admet-2802	313	10	permanent	permanent	ADJ
admet-2802	313	11	cations	cation	NOUN
admet-2802	313	12	)	)	PUNCT
admet-2802	313	13	can	can	AUX
admet-2802	313	14	also	also	ADV
admet-2802	313	15	bind	bind	VERB
admet-2802	313	16	to	to	ADP
admet-2802	313	17	bile	bile	NOUN
admet-2802	313	18	micelles	micelle	NOUN
admet-2802	313	19	[	[	X
admet-2802	313	20	25,26	25,26	X
admet-2802	313	21	]	]	X
admet-2802	313	22	.	.	PUNCT
admet-2802	314	1	since	since	SCONJ
admet-2802	314	2	there	there	PRON
admet-2802	314	3	is	be	VERB
admet-2802	314	4	no	no	DET
admet-2802	314	5	general	general	ADJ
admet-2802	314	6	rule	rule	NOUN
admet-2802	314	7	for	for	ADP
admet-2802	314	8	kbm,+1	kbm,+1	PROPN
admet-2802	314	9	/	/	SYM
admet-2802	314	10	kbm,0	kbm,0	PROPN
admet-2802	314	11	,	,	PUNCT
admet-2802	314	12	kbm,+1	kbm,+1	PROPN
admet-2802	314	13	,	,	PUNCT
admet-2802	314	14	and	and	CCONJ
admet-2802	314	15	kbm,0	kbm,0	PROPN
admet-2802	314	16	should	should	AUX
admet-2802	314	17	be	be	AUX
admet-2802	314	18	experimentally	experimentally	ADV
admet-2802	314	19	measured	measure	VERB
admet-2802	314	20	from	from	ADP
admet-2802	314	21	the	the	DET
admet-2802	314	22	ph	ph	VERB
admet-2802	314	23	-	-	PUNCT
admet-2802	314	24	fu	fu	NOUN
admet-2802	314	25	profile	profile	NOUN
admet-2802	314	26	.	.	PUNCT
admet-2802	315	1	the	the	DET
admet-2802	315	2	oral	oral	ADJ
admet-2802	315	3	absorption	absorption	NOUN
admet-2802	315	4	of	of	ADP
admet-2802	315	5	quinine	quinine	PROPN
admet-2802	315	6	is	be	AUX
admet-2802	315	7	reduced	reduce	VERB
admet-2802	315	8	by	by	ADP
admet-2802	315	9	bile	bile	NOUN
admet-2802	315	10	micelles	micelle	NOUN
admet-2802	315	11	in	in	ADP
admet-2802	315	12	vivo	vivo	NOUN
admet-2802	315	13	[	[	X
admet-2802	315	14	32	32	NUM
admet-2802	315	15	]	]	PUNCT
admet-2802	315	16	,	,	PUNCT
admet-2802	315	17	in	in	ADP
admet-2802	315	18	good	good	ADJ
admet-2802	315	19	agreement	agreement	NOUN
admet-2802	315	20	with	with	ADP
admet-2802	315	21	the	the	DET
admet-2802	315	22	result	result	NOUN
admet-2802	315	23	of	of	ADP
admet-2802	315	24	this	this	DET
admet-2802	315	25	study	study	NOUN
admet-2802	315	26	.	.	PUNCT
admet-2802	316	1	at	at	ADP
admet-2802	316	2	ph	ph	PROPN
admet-2802	316	3	6.5	6.5	NUM
admet-2802	316	4	,	,	PUNCT
admet-2802	316	5	quinine	quinine	PROPN
admet-2802	316	6	mainly	mainly	ADV
admet-2802	316	7	exists	exist	VERB
admet-2802	316	8	as	as	ADP
admet-2802	316	9	z	z	NOUN
admet-2802	316	10	=	=	SYM
admet-2802	316	11	+1	+1	ADJ
admet-2802	316	12	species	specie	NOUN
admet-2802	316	13	.	.	PUNCT
admet-2802	317	1	the	the	DET
admet-2802	317	2	fu	fu	PROPN
admet-2802	317	3	values	value	NOUN
admet-2802	317	4	of	of	ADP
admet-2802	317	5	the	the	DET
admet-2802	317	6	zwitterionic	zwitterionic	ADJ
admet-2802	317	7	drugs	drug	NOUN
admet-2802	317	8	(	(	PUNCT
admet-2802	317	9	z	z	NOUN
admet-2802	317	10	=	=	SYM
admet-2802	317	11	±0	±0	NOUN
admet-2802	317	12	)	)	PUNCT
admet-2802	317	13	are	be	AUX
admet-2802	317	14	less	less	ADJ
admet-2802	317	15	than	than	ADP
admet-2802	317	16	1	1	NUM
admet-2802	317	17	at	at	ADP
admet-2802	317	18	ph	ph	PROPN
admet-2802	317	19	6.5	6.5	NUM
admet-2802	317	20	,	,	PUNCT
admet-2802	317	21	in	in	ADP
admet-2802	317	22	good	good	ADJ
admet-2802	317	23	agreement	agreement	NOUN
admet-2802	317	24	with	with	ADP
admet-2802	317	25	the	the	DET
admet-2802	317	26	negative	negative	ADJ
admet-2802	317	27	food	food	NOUN
admet-2802	317	28	effect	effect	NOUN
admet-2802	317	29	[	[	X
admet-2802	317	30	25	25	NUM
admet-2802	317	31	]	]	PUNCT
admet-2802	317	32	,	,	PUNCT
admet-2802	317	33	suggesting	suggest	VERB
admet-2802	317	34	that	that	SCONJ
admet-2802	317	35	kbm,±0	kbm,±0	NOUN
admet-2802	317	36	should	should	AUX
admet-2802	317	37	also	also	ADV
admet-2802	317	38	be	be	AUX
admet-2802	317	39	considered	consider	VERB
admet-2802	317	40	.	.	PUNCT
admet-2802	318	1	dynamic	dynamic	ADJ
admet-2802	318	2	dialysis	dialysis	NOUN
admet-2802	318	3	would	would	AUX
admet-2802	318	4	be	be	AUX
admet-2802	318	5	a	a	DET
admet-2802	318	6	suitable	suitable	ADJ
admet-2802	318	7	tool	tool	NOUN
admet-2802	318	8	to	to	PART
admet-2802	318	9	measure	measure	VERB
admet-2802	318	10	fu	fu	NOUN
admet-2802	318	11	for	for	ADP
admet-2802	318	12	high	high	ADJ
admet-2802	318	13	solubility	solubility	NOUN
admet-2802	318	14	drugs	drug	NOUN
admet-2802	318	15	[	[	X
admet-2802	318	16	33	33	NUM
admet-2802	318	17	]	]	PUNCT
admet-2802	318	18	.	.	PUNCT
admet-2802	319	1	conclusions	conclusion	NOUN
admet-2802	319	2	the	the	DET
admet-2802	319	3	bile	bile	NOUN
admet-2802	319	4	micelle	micelle	NOUN
admet-2802	319	5	partitioning	partition	VERB
admet-2802	319	6	of	of	ADP
admet-2802	319	7	anionic	anionic	ADJ
admet-2802	319	8	species	specie	NOUN
admet-2802	319	9	(	(	PUNCT
admet-2802	319	10	z	z	NOUN
admet-2802	319	11	=	=	SYM
admet-2802	319	12	-1	-1	NOUN
admet-2802	319	13	)	)	PUNCT
admet-2802	319	14	of	of	ADP
admet-2802	319	15	highly	highly	ADV
admet-2802	319	16	soluble	soluble	ADJ
admet-2802	319	17	weak	weak	ADJ
admet-2802	319	18	acid	acid	NOUN
admet-2802	319	19	drugs	drug	NOUN
admet-2802	319	20	was	be	AUX
admet-2802	319	21	negligible	negligible	ADJ
admet-2802	319	22	.	.	PUNCT
admet-2802	320	1	on	on	ADP
admet-2802	320	2	the	the	DET
admet-2802	320	3	other	other	ADJ
admet-2802	320	4	hand	hand	NOUN
admet-2802	320	5	,	,	PUNCT
admet-2802	320	6	kbm,+1	kbm,+1	NOUN
admet-2802	320	7	/kbm,0	/kbm,0	PUNCT
admet-2802	320	8	ranged	range	VERB
admet-2802	320	9	from	from	ADP
admet-2802	320	10	0.24	0.24	NUM
admet-2802	320	11	to	to	ADP
admet-2802	320	12	2.6	2.6	NUM
admet-2802	320	13	for	for	ADP
admet-2802	320	14	highly	highly	ADV
admet-2802	320	15	soluble	soluble	ADJ
admet-2802	320	16	weak	weak	ADJ
admet-2802	320	17	base	base	NOUN
admet-2802	320	18	drugs	drug	NOUN
admet-2802	320	19	.	.	PUNCT
admet-2802	321	1	in	in	ADP
admet-2802	321	2	about	about	ADV
admet-2802	321	3	half	half	NOUN
admet-2802	321	4	of	of	ADP
admet-2802	321	5	the	the	DET
admet-2802	321	6	cases	case	NOUN
admet-2802	321	7	,	,	PUNCT
admet-2802	321	8	the	the	DET
admet-2802	321	9	mono	mono	NOUN
admet-2802	321	10	-	-	PUNCT
admet-2802	321	11	cationic	cationic	ADJ
admet-2802	321	12	species	specie	NOUN
admet-2802	321	13	(	(	PUNCT
admet-2802	321	14	z	z	NOUN
admet-2802	321	15	=	=	SYM
admet-2802	321	16	+1	+1	PROPN
admet-2802	321	17	)	)	PUNCT
admet-2802	321	18	were	be	AUX
admet-2802	321	19	bound	bind	VERB
admet-2802	321	20	to	to	PART
admet-2802	321	21	bile	bile	NOUN
admet-2802	321	22	micelles	micelle	NOUN
admet-2802	321	23	equal	equal	ADJ
admet-2802	321	24	to	to	ADP
admet-2802	321	25	or	or	CCONJ
admet-2802	321	26	greater	great	ADJ
admet-2802	321	27	than	than	ADP
admet-2802	321	28	the	the	DET
admet-2802	321	29	un	un	ADJ
admet-2802	321	30	-	-	ADJ
admet-2802	321	31	ionized	ionized	ADJ
admet-2802	321	32	species	specie	NOUN
admet-2802	321	33	(	(	PUNCT
admet-2802	321	34	kbm,+1	kbm,+1	PROPN
admet-2802	321	35	/	/	SYM
admet-2802	321	36	kbm,0	kbm,0	PROPN
admet-2802	321	37	≥	≥	PROPN
admet-2802	321	38	1.0	1.0	NUM
admet-2802	321	39	)	)	PUNCT
admet-2802	321	40	.	.	PUNCT
admet-2802	322	1	di	di	NOUN
admet-2802	322	2	-	-	NOUN
admet-2802	322	3	cationic	cationic	ADJ
admet-2802	322	4	(	(	PUNCT
admet-2802	322	5	z	z	NOUN
admet-2802	322	6	=	=	SYM
admet-2802	322	7	+2	+2	PROPN
admet-2802	322	8	)	)	PUNCT
admet-2802	322	9	and	and	CCONJ
admet-2802	322	10	zwitterionic	zwitterionic	ADJ
admet-2802	322	11	species	specie	NOUN
admet-2802	322	12	(	(	PUNCT
admet-2802	322	13	z	z	NOUN
admet-2802	322	14	=	=	SYM
admet-2802	322	15	±0	±0	NOUN
admet-2802	322	16	)	)	PUNCT
admet-2802	322	17	also	also	ADV
admet-2802	322	18	bound	bind	VERB
admet-2802	322	19	to	to	ADP
admet-2802	322	20	the	the	DET
admet-2802	322	21	bile	bile	NOUN
admet-2802	322	22	micelles	micelle	NOUN
admet-2802	322	23	to	to	ADP
admet-2802	322	24	some	some	DET
admet-2802	322	25	extent	extent	NOUN
admet-2802	322	26	.	.	PUNCT
admet-2802	323	1	therefore	therefore	ADV
admet-2802	323	2	,	,	PUNCT
admet-2802	323	3	the	the	DET
admet-2802	323	4	bile	bile	NOUN
admet-2802	323	5	micelle	micelle	NOUN
admet-2802	323	6	binding	bind	VERB
admet-2802	323	7	of	of	ADP
admet-2802	323	8	z=+1	z=+1	PROPN
admet-2802	323	9	,	,	PUNCT
admet-2802	323	10	+2	+2	PRON
admet-2802	323	11	and	and	CCONJ
admet-2802	323	12	±0	±0	ADJ
admet-2802	323	13	species	specie	NOUN
admet-2802	323	14	should	should	AUX
admet-2802	323	15	be	be	AUX
admet-2802	323	16	considered	consider	VERB
admet-2802	323	17	in	in	ADP
admet-2802	323	18	food	food	NOUN
admet-2802	323	19	effect	effect	NOUN
admet-2802	323	20	prediction	prediction	NOUN
admet-2802	323	21	.	.	PUNCT
admet-2802	324	1	lo	lo	PROPN
admet-2802	325	1	g	g	PROPN
admet-2802	326	1	k	k	PROPN
admet-2802	327	1	b	b	PROPN
admet-2802	327	2	m	m	PROPN
admet-2802	327	3	,	,	PUNCT
admet-2802	327	4	0	0	NUM
admet-2802	327	5	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	PROPN
admet-2802	327	6	m.	m.	NOUN
admet-2802	327	7	konishi	konishi	PROPN
admet-2802	327	8	and	and	CCONJ
admet-2802	327	9	k.	k.	PROPN
admet-2802	327	10	sugano	sugano	PROPN
admet-2802	327	11	admet	admet	PROPN
admet-2802	327	12	&	&	CCONJ
admet-2802	327	13	dmpk	dmpk	PROPN
admet-2802	327	14	13(4	13(4	NUM
admet-2802	327	15	)	)	PUNCT
admet-2802	327	16	(	(	PUNCT
admet-2802	327	17	2025	2025	NUM
admet-2802	327	18	)	)	PUNCT
admet-2802	327	19	2802	2802	NUM
admet-2802	327	20	10	10	NUM
admet-2802	327	21	funding	funding	NOUN
admet-2802	327	22	:	:	PUNCT
admet-2802	327	23	no	no	DET
admet-2802	327	24	funding	funding	NOUN
admet-2802	327	25	support	support	NOUN
admet-2802	327	26	conflict	conflict	NOUN
admet-2802	327	27	of	of	ADP
admet-2802	327	28	interest	interest	NOUN
admet-2802	327	29	:	:	PUNCT
admet-2802	327	30	the	the	DET
admet-2802	327	31	author(s	author(s	PROPN
admet-2802	327	32	)	)	PUNCT
admet-2802	327	33	declare(s	declare(s	PROPN
admet-2802	327	34	)	)	PUNCT
admet-2802	327	35	that	that	SCONJ
admet-2802	327	36	they	they	PRON
admet-2802	327	37	have	have	VERB
admet-2802	327	38	no	no	DET
admet-2802	327	39	conflicts	conflict	NOUN
admet-2802	327	40	of	of	ADP
admet-2802	327	41	interest	interest	NOUN
admet-2802	327	42	to	to	PART
admet-2802	327	43	disclose	disclose	VERB
admet-2802	327	44	.	.	PUNCT
admet-2802	328	1	author	author	NOUN
admet-2802	328	2	contributions	contribution	NOUN
admet-2802	328	3	:	:	PUNCT
admet-2802	328	4	material	material	NOUN
admet-2802	328	5	preparation	preparation	NOUN
admet-2802	328	6	,	,	PUNCT
admet-2802	328	7	data	data	NOUN
admet-2802	328	8	collection	collection	NOUN
admet-2802	328	9	,	,	PUNCT
admet-2802	328	10	and	and	CCONJ
admet-2802	328	11	analysis	analysis	NOUN
admet-2802	328	12	were	be	AUX
admet-2802	328	13	performed	perform	VERB
admet-2802	328	14	by	by	ADP
admet-2802	328	15	mayu	mayu	PROPN
admet-2802	328	16	konishi	konishi	PROPN
admet-2802	328	17	.	.	PUNCT
admet-2802	329	1	kiyohiko	kiyohiko	PROPN
admet-2802	329	2	sugano	sugano	PROPN
admet-2802	329	3	supervised	supervise	VERB
admet-2802	329	4	all	all	DET
admet-2802	329	5	phases	phase	NOUN
admet-2802	329	6	of	of	ADP
admet-2802	329	7	the	the	DET
admet-2802	329	8	study	study	NOUN
admet-2802	329	9	,	,	PUNCT
admet-2802	329	10	including	include	VERB
admet-2802	329	11	the	the	DET
admet-2802	329	12	manuscript	manuscript	NOUN
admet-2802	329	13	writing	writing	NOUN
admet-2802	329	14	.	.	PUNCT
admet-2802	330	1	all	all	DET
admet-2802	330	2	authors	author	NOUN
admet-2802	330	3	read	read	VERB
admet-2802	330	4	and	and	CCONJ
admet-2802	330	5	approved	approve	VERB
admet-2802	330	6	the	the	DET
admet-2802	330	7	final	final	ADJ
admet-2802	330	8	manuscript	manuscript	NOUN
admet-2802	330	9	.	.	PUNCT
admet-2802	331	1	data	datum	NOUN
admet-2802	331	2	availability	availability	NOUN
admet-2802	331	3	:	:	PUNCT
admet-2802	331	4	the	the	DET
admet-2802	331	5	datasets	dataset	NOUN
admet-2802	331	6	generated	generate	VERB
admet-2802	331	7	during	during	ADP
admet-2802	331	8	and/or	and/or	CCONJ
admet-2802	331	9	analysed	analyse	VERB
admet-2802	331	10	during	during	ADP
admet-2802	331	11	the	the	DET
admet-2802	331	12	current	current	ADJ
admet-2802	331	13	study	study	NOUN
admet-2802	331	14	are	be	AUX
admet-2802	331	15	available	available	ADJ
admet-2802	331	16	from	from	ADP
admet-2802	331	17	the	the	DET
admet-2802	331	18	corresponding	corresponding	ADJ
admet-2802	331	19	author	author	NOUN
admet-2802	331	20	on	on	ADP
admet-2802	331	21	request	request	NOUN
admet-2802	331	22	.	.	PUNCT
admet-2802	332	1	references	reference	NOUN
admet-2802	332	2	[	[	X
admet-2802	332	3	1	1	X
admet-2802	332	4	]	]	X
admet-2802	332	5	d.m	d.m	PROPN
admet-2802	332	6	.	.	PROPN
admet-2802	332	7	mudie	mudie	PROPN
admet-2802	332	8	,	,	PUNCT
admet-2802	332	9	g.l	g.l	PROPN
admet-2802	332	10	.	.	PROPN
admet-2802	332	11	amidon	amidon	PROPN
admet-2802	332	12	,	,	PUNCT
admet-2802	332	13	g.e	g.e	PROPN
admet-2802	332	14	.	.	PROPN
admet-2802	332	15	amidon	amidon	PROPN
admet-2802	332	16	.	.	PUNCT
admet-2802	333	1	physiological	physiological	ADJ
admet-2802	333	2	parameters	parameter	NOUN
admet-2802	333	3	for	for	ADP
admet-2802	333	4	oral	oral	ADJ
admet-2802	333	5	delivery	delivery	NOUN
admet-2802	333	6	and	and	CCONJ
admet-2802	333	7	in	in	ADP
admet-2802	333	8	vitro	vitro	X
admet-2802	333	9	testing	testing	NOUN
admet-2802	333	10	.	.	PUNCT
admet-2802	334	1	molecular	molecular	ADJ
admet-2802	334	2	pharmaceutics	pharmaceutic	NOUN
admet-2802	334	3	7	7	NUM
admet-2802	334	4	(	(	PUNCT
admet-2802	334	5	2010	2010	NUM
admet-2802	334	6	)	)	PUNCT
admet-2802	334	7	1388	1388	NUM
admet-2802	334	8	-	-	SYM
admet-2802	334	9	1405	1405	NUM
admet-2802	334	10	.	.	PUNCT
admet-2802	335	1	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	PUNCT
admet-2802	336	1	[	[	X
admet-2802	336	2	2	2	X
admet-2802	336	3	]	]	PUNCT
admet-2802	336	4	d.	d.	PROPN
admet-2802	336	5	riethorst	riethorst	PROPN
admet-2802	336	6	,	,	PUNCT
admet-2802	336	7	r.	r.	PROPN
admet-2802	336	8	mols	mols	PROPN
admet-2802	336	9	,	,	PUNCT
admet-2802	336	10	g.	g.	PROPN
admet-2802	336	11	duchateau	duchateau	PROPN
admet-2802	336	12	,	,	PUNCT
admet-2802	336	13	j.	j.	PROPN
admet-2802	336	14	tack	tack	PROPN
admet-2802	336	15	,	,	PUNCT
admet-2802	336	16	j.	j.	PROPN
admet-2802	336	17	brouwers	brouwers	PROPN
admet-2802	336	18	,	,	PUNCT
admet-2802	336	19	p.	p.	NOUN
admet-2802	336	20	augustijns	augustijns	NOUN
admet-2802	336	21	.	.	PUNCT
admet-2802	337	1	characterization	characterization	NOUN
admet-2802	337	2	of	of	ADP
admet-2802	337	3	human	human	ADJ
admet-2802	337	4	duodenal	duodenal	ADJ
admet-2802	337	5	fluids	fluid	NOUN
admet-2802	337	6	in	in	ADP
admet-2802	337	7	fasted	fast	VERB
admet-2802	337	8	and	and	CCONJ
admet-2802	337	9	fed	feed	VERB
admet-2802	337	10	state	state	NOUN
admet-2802	337	11	conditions	condition	NOUN
admet-2802	337	12	.	.	PUNCT
admet-2802	338	1	journal	journal	NOUN
admet-2802	338	2	of	of	ADP
admet-2802	338	3	pharmaceutical	pharmaceutical	PROPN
admet-2802	338	4	sciences	science	NOUN
admet-2802	338	5	105	105	NUM
admet-2802	338	6	(	(	PUNCT
admet-2802	338	7	2016	2016	NUM
admet-2802	338	8	)	)	PUNCT
admet-2802	338	9	673	673	NUM
admet-2802	338	10	-	-	SYM
admet-2802	338	11	681	681	NUM
admet-2802	338	12	.	.	PUNCT
admet-2802	339	1	https://doi.org/10.1002/jps.24603	https://doi.org/10.1002/jps.24603	NOUN
admet-2802	339	2	[	[	X
admet-2802	339	3	3	3	NUM
admet-2802	339	4	]	]	X
admet-2802	339	5	l.g.a.-a	l.g.a.-a	PROPN
admet-2802	339	6	.	.	PUNCT
admet-2802	339	7	santos	santos	PROPN
admet-2802	339	8	,	,	PUNCT
admet-2802	339	9	h.	h.	PROPN
admet-2802	339	10	musther	musther	PROPN
admet-2802	339	11	,	,	PUNCT
admet-2802	339	12	n.	n.	PROPN
admet-2802	339	13	bala	bala	PROPN
admet-2802	339	14	,	,	PUNCT
admet-2802	339	15	n.	n.	PROPN
admet-2802	339	16	deferm	deferm	PROPN
admet-2802	339	17	,	,	PUNCT
admet-2802	339	18	g.	g.	PROPN
admet-2802	339	19	patel	patel	PROPN
admet-2802	339	20	,	,	PUNCT
admet-2802	339	21	j.	j.	PROPN
admet-2802	339	22	brouwers	brouwers	PROPN
admet-2802	339	23	,	,	PUNCT
admet-2802	339	24	d.b	d.b	PROPN
admet-2802	339	25	.	.	PROPN
admet-2802	339	26	turner	turner	PROPN
admet-2802	339	27	.	.	PUNCT
admet-2802	340	1	gastrointestinal	gastrointestinal	ADJ
admet-2802	340	2	bile	bile	NOUN
admet-2802	340	3	salt	salt	NOUN
admet-2802	340	4	concentrations	concentration	NOUN
admet-2802	340	5	in	in	ADP
admet-2802	340	6	healthy	healthy	ADJ
admet-2802	340	7	adults	adult	NOUN
admet-2802	340	8	under	under	ADP
admet-2802	340	9	fasted	fast	VERB
admet-2802	340	10	and	and	CCONJ
admet-2802	340	11	fed	fed	PROPN
admet-2802	340	12	conditions	condition	NOUN
admet-2802	340	13	:	:	PUNCT
admet-2802	340	14	a	a	DET
admet-2802	340	15	systematic	systematic	ADJ
admet-2802	340	16	review	review	NOUN
admet-2802	340	17	and	and	CCONJ
admet-2802	340	18	meta	meta	NOUN
admet-2802	340	19	-	-	PUNCT
admet-2802	340	20	analysis	analysis	NOUN
admet-2802	340	21	for	for	ADP
admet-2802	340	22	mechanistic	mechanistic	ADJ
admet-2802	340	23	physiologically	physiologically	ADV
admet-2802	340	24	-	-	PUNCT
admet-2802	340	25	based	base	VERB
admet-2802	340	26	pharmacokinetic	pharmacokinetic	ADJ
admet-2802	340	27	(	(	PUNCT
admet-2802	340	28	pbpk	pbpk	NOUN
admet-2802	340	29	)	)	PUNCT
admet-2802	340	30	modelling	modelling	NOUN
admet-2802	340	31	.	.	PUNCT
admet-2802	341	1	the	the	DET
admet-2802	341	2	aaps	aaps	PROPN
admet-2802	341	3	journal	journal	PROPN
admet-2802	341	4	27	27	NUM
admet-2802	341	5	(	(	PUNCT
admet-2802	341	6	2025	2025	NUM
admet-2802	341	7	)	)	PUNCT
admet-2802	341	8	31	31	NUM
admet-2802	341	9	.	.	PUNCT
admet-2802	342	1	https://doi.org/10.1208/s12248-025-01016-x	https://doi.org/10.1208/s12248-025-01016-x	NOUN
admet-2802	343	1	[	[	X
admet-2802	343	2	4	4	NUM
admet-2802	343	3	]	]	X
admet-2802	343	4	y.	y.	PROPN
admet-2802	343	5	akiyama	akiyama	PROPN
admet-2802	343	6	,	,	PUNCT
admet-2802	343	7	s.	s.	PROPN
admet-2802	343	8	ito	ito	PROPN
admet-2802	343	9	,	,	PUNCT
admet-2802	343	10	t.	t.	PROPN
admet-2802	343	11	fujita	fujita	PROPN
admet-2802	343	12	,	,	PUNCT
admet-2802	343	13	k.	k.	PROPN
admet-2802	343	14	sugano	sugano	PROPN
admet-2802	343	15	.	.	PUNCT
admet-2802	344	1	prediction	prediction	NOUN
admet-2802	344	2	of	of	ADP
admet-2802	344	3	negative	negative	ADJ
admet-2802	344	4	food	food	NOUN
admet-2802	344	5	effect	effect	NOUN
admet-2802	344	6	induced	induce	VERB
admet-2802	344	7	by	by	ADP
admet-2802	344	8	bile	bile	NOUN
admet-2802	344	9	micelle	micelle	NOUN
admet-2802	344	10	binding	bind	VERB
admet-2802	344	11	on	on	ADP
admet-2802	344	12	oral	oral	ADJ
admet-2802	344	13	absorption	absorption	NOUN
admet-2802	344	14	of	of	ADP
admet-2802	344	15	hydrophilic	hydrophilic	ADJ
admet-2802	344	16	cationic	cationic	ADJ
admet-2802	344	17	drugs	drug	NOUN
admet-2802	344	18	.	.	PUNCT
admet-2802	345	1	european	european	ADJ
admet-2802	345	2	journal	journal	PROPN
admet-2802	345	3	of	of	ADP
admet-2802	345	4	pharmaceutical	pharmaceutical	PROPN
admet-2802	345	5	sciences	science	NOUN
admet-2802	345	6	155	155	NUM
admet-2802	345	7	(	(	PUNCT
admet-2802	345	8	2020	2020	NUM
admet-2802	345	9	)	)	PUNCT
admet-2802	345	10	105543	105543	NUM
admet-2802	345	11	.	.	PUNCT
admet-2802	346	1	https://doi.org/10.1016/j.ejps.2020.105543	https://doi.org/10.1016/j.ejps.2020.105543	VERB
admet-2802	346	2	[	[	X
admet-2802	346	3	5	5	NUM
admet-2802	346	4	]	]	PUNCT
admet-2802	346	5	k.	k.	PROPN
admet-2802	346	6	sugano	sugano	PROPN
admet-2802	346	7	,	,	PUNCT
admet-2802	346	8	m.	m.	NOUN
admet-2802	346	9	kataoka	kataoka	PROPN
admet-2802	346	10	,	,	PUNCT
admet-2802	346	11	c.	c.	PROPN
admet-2802	346	12	da	da	PROPN
admet-2802	346	13	costa	costa	PROPN
admet-2802	346	14	mathews	mathews	PROPN
admet-2802	346	15	,	,	PUNCT
admet-2802	346	16	s.	s.	PROPN
admet-2802	346	17	yamashita	yamashita	PROPN
admet-2802	346	18	.	.	PUNCT
admet-2802	347	1	prediction	prediction	NOUN
admet-2802	347	2	of	of	ADP
admet-2802	347	3	food	food	NOUN
admet-2802	347	4	effect	effect	NOUN
admet-2802	347	5	by	by	ADP
admet-2802	347	6	bile	bile	NOUN
admet-2802	347	7	micelles	micelle	NOUN
admet-2802	347	8	on	on	ADP
admet-2802	347	9	oral	oral	ADJ
admet-2802	347	10	drug	drug	NOUN
admet-2802	347	11	absorption	absorption	NOUN
admet-2802	347	12	considering	consider	VERB
admet-2802	347	13	free	free	ADJ
admet-2802	347	14	fraction	fraction	NOUN
admet-2802	347	15	in	in	ADP
admet-2802	347	16	intestinal	intestinal	ADJ
admet-2802	347	17	fluid	fluid	NOUN
admet-2802	347	18	.	.	PUNCT
admet-2802	348	1	european	european	ADJ
admet-2802	348	2	journal	journal	PROPN
admet-2802	348	3	of	of	ADP
admet-2802	348	4	pharmaceutical	pharmaceutical	PROPN
admet-2802	348	5	sciences	science	NOUN
admet-2802	348	6	40	40	NUM
admet-2802	348	7	(	(	PUNCT
admet-2802	348	8	2010	2010	NUM
admet-2802	348	9	)	)	PUNCT
admet-2802	348	10	118	118	NUM
admet-2802	348	11	-	-	SYM
admet-2802	348	12	124	124	NUM
admet-2802	348	13	.	.	PUNCT
admet-2802	349	1	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-2802	349	2	[	[	X
admet-2802	349	3	6	6	NUM
admet-2802	349	4	]	]	PUNCT
admet-2802	349	5	b.	b.	PROPN
admet-2802	349	6	wuyts	wuyts	PROPN
admet-2802	349	7	,	,	PUNCT
admet-2802	349	8	d.	d.	PROPN
admet-2802	349	9	riethorst	riethorst	PROPN
admet-2802	349	10	,	,	PUNCT
admet-2802	349	11	j.	j.	PROPN
admet-2802	349	12	brouwers	brouwers	PROPN
admet-2802	349	13	,	,	PUNCT
admet-2802	349	14	j.	j.	PROPN
admet-2802	349	15	tack	tack	PROPN
admet-2802	349	16	,	,	PUNCT
admet-2802	349	17	p.	p.	PROPN
admet-2802	349	18	annaert	annaert	NOUN
admet-2802	349	19	,	,	PUNCT
admet-2802	349	20	p.	p.	NOUN
admet-2802	349	21	augustijns	augustijns	NOUN
admet-2802	349	22	.	.	PUNCT
admet-2802	350	1	evaluation	evaluation	NOUN
admet-2802	350	2	of	of	ADP
admet-2802	350	3	fasted	fast	VERB
admet-2802	350	4	and	and	CCONJ
admet-2802	350	5	fed	feed	VERB
admet-2802	350	6	state	state	PROPN
admet-2802	350	7	simulated	simulate	VERB
admet-2802	350	8	and	and	CCONJ
admet-2802	350	9	human	human	ADJ
admet-2802	350	10	intestinal	intestinal	ADJ
admet-2802	350	11	fluids	fluid	NOUN
admet-2802	350	12	as	as	ADP
admet-2802	350	13	solvent	solvent	ADJ
admet-2802	350	14	system	system	NOUN
admet-2802	350	15	in	in	ADP
admet-2802	350	16	the	the	DET
admet-2802	350	17	ussing	usse	VERB
admet-2802	350	18	chambers	chamber	NOUN
admet-2802	350	19	model	model	NOUN
admet-2802	350	20	to	to	PART
admet-2802	350	21	explore	explore	VERB
admet-2802	350	22	food	food	NOUN
admet-2802	350	23	effects	effect	NOUN
admet-2802	350	24	on	on	ADP
admet-2802	350	25	intestinal	intestinal	ADJ
admet-2802	350	26	permeability	permeability	NOUN
admet-2802	350	27	.	.	PUNCT
admet-2802	351	1	international	international	ADJ
admet-2802	351	2	journal	journal	PROPN
admet-2802	351	3	of	of	ADP
admet-2802	351	4	pharmaceutics	pharmaceutic	NOUN
admet-2802	351	5	478	478	NUM
admet-2802	351	6	(	(	PUNCT
admet-2802	351	7	2015	2015	NUM
admet-2802	351	8	)	)	PUNCT
admet-2802	351	9	736	736	NUM
admet-2802	351	10	-	-	SYM
admet-2802	351	11	744	744	NUM
admet-2802	351	12	.	.	PUNCT
admet-2802	352	1	https://doi.org/10.1016/j.ijpharm.2014.12.021	https://doi.org/10.1016/j.ijpharm.2014.12.021	NOUN
admet-2802	353	1	[	[	X
admet-2802	353	2	7	7	X
admet-2802	353	3	]	]	X
admet-2802	353	4	b.	b.	PROPN
admet-2802	353	5	wuyts	wuyts	PROPN
admet-2802	353	6	,	,	PUNCT
admet-2802	353	7	d.	d.	PROPN
admet-2802	353	8	riethorst	riethorst	PROPN
admet-2802	353	9	,	,	PUNCT
admet-2802	353	10	j.	j.	PROPN
admet-2802	353	11	brouwers	brouwers	PROPN
admet-2802	353	12	,	,	PUNCT
admet-2802	353	13	j.	j.	PROPN
admet-2802	353	14	tack	tack	PROPN
admet-2802	353	15	,	,	PUNCT
admet-2802	353	16	p.	p.	PROPN
admet-2802	353	17	annaert	annaert	NOUN
admet-2802	353	18	,	,	PUNCT
admet-2802	353	19	p.	p.	NOUN
admet-2802	353	20	augustijns	augustijns	NOUN
admet-2802	353	21	.	.	PUNCT
admet-2802	354	1	evaluation	evaluation	NOUN
admet-2802	354	2	of	of	ADP
admet-2802	354	3	fasted	fast	VERB
admet-2802	354	4	state	state	NOUN
admet-2802	354	5	human	human	ADJ
admet-2802	354	6	intestinal	intestinal	ADJ
admet-2802	354	7	fluid	fluid	NOUN
admet-2802	354	8	as	as	ADP
admet-2802	354	9	apical	apical	ADJ
admet-2802	354	10	solvent	solvent	NOUN
admet-2802	354	11	system	system	NOUN
admet-2802	354	12	in	in	ADP
admet-2802	354	13	the	the	DET
admet-2802	354	14	caco-2	caco-2	NUM
admet-2802	354	15	absorption	absorption	NOUN
admet-2802	354	16	model	model	NOUN
admet-2802	354	17	and	and	CCONJ
admet-2802	354	18	comparison	comparison	NOUN
admet-2802	354	19	with	with	ADP
admet-2802	354	20	fassif	fassif	NOUN
admet-2802	354	21	.	.	PUNCT
admet-2802	355	1	european	european	PROPN
admet-2802	355	2	journal	journal	PROPN
admet-2802	355	3	of	of	ADP
admet-2802	355	4	pharmaceutical	pharmaceutical	PROPN
admet-2802	355	5	sciences	science	NOUN
admet-2802	355	6	67	67	NUM
admet-2802	355	7	(	(	PUNCT
admet-2802	355	8	2015	2015	NUM
admet-2802	355	9	)	)	PUNCT
admet-2802	355	10	126	126	NUM
admet-2802	355	11	-	-	SYM
admet-2802	355	12	135	135	NUM
admet-2802	355	13	.	.	PUNCT
admet-2802	356	1	https://doi.org/10.1016/j.ejps.2014.11.010	https://doi.org/10.1016/j.ejps.2014.11.010	NOUN
admet-2802	356	2	[	[	X
admet-2802	356	3	8	8	X
admet-2802	356	4	]	]	PUNCT
admet-2802	356	5	t.	t.	PROPN
admet-2802	356	6	yamaguchi	yamaguchi	PROPN
admet-2802	356	7	,	,	PUNCT
admet-2802	356	8	c.	c.	PROPN
admet-2802	356	9	ikeda	ikeda	PROPN
admet-2802	356	10	,	,	PUNCT
admet-2802	356	11	y.	y.	PROPN
admet-2802	356	12	sekine	sekine	PROPN
admet-2802	356	13	.	.	PUNCT
admet-2802	357	1	intestinal	intestinal	ADJ
admet-2802	357	2	absorption	absorption	NOUN
admet-2802	357	3	of	of	ADP
admet-2802	357	4	β	β	ADJ
admet-2802	357	5	-	-	ADJ
admet-2802	357	6	adrenergic	adrenergic	ADJ
admet-2802	357	7	blocking	block	VERB
admet-2802	357	8	agent	agent	NOUN
admet-2802	357	9	nadolol	nadolol	NOUN
admet-2802	357	10	.	.	PUNCT
admet-2802	358	1	i.	i.	NOUN
admet-2802	358	2	:	:	PUNCT
admet-2802	358	3	comparison	comparison	NOUN
admet-2802	358	4	of	of	ADP
admet-2802	358	5	absorption	absorption	NOUN
admet-2802	358	6	behaivor	behaivor	NOUN
admet-2802	358	7	of	of	ADP
admet-2802	358	8	nadolol	nadolol	NOUN
admet-2802	358	9	with	with	ADP
admet-2802	358	10	those	those	PRON
admet-2802	358	11	of	of	ADP
admet-2802	358	12	other	other	ADJ
admet-2802	358	13	β	β	X
admet-2802	358	14	-	-	ADJ
admet-2802	358	15	blocking	block	VERB
admet-2802	358	16	agents	agent	NOUN
admet-2802	358	17	in	in	ADP
admet-2802	358	18	rats	rat	NOUN
admet-2802	358	19	.	.	PUNCT
admet-2802	359	1	chemical	chemical	NOUN
admet-2802	359	2	and	and	CCONJ
admet-2802	359	3	pharmaceutical	pharmaceutical	ADJ
admet-2802	359	4	bulletin	bulletin	NOUN
admet-2802	359	5	34	34	NUM
admet-2802	359	6	(	(	PUNCT
admet-2802	359	7	1986	1986	NUM
admet-2802	359	8	)	)	PUNCT
admet-2802	359	9	3362	3362	NUM
admet-2802	359	10	-	-	SYM
admet-2802	359	11	3369	3369	NUM
admet-2802	359	12	.	.	PUNCT
admet-2802	360	1	https://doi.org/10.1248/cpb.34.3362	https://doi.org/10.1248/cpb.34.3362	X
admet-2802	361	1	[	[	X
admet-2802	361	2	9	9	X
admet-2802	361	3	]	]	SYM
admet-2802	361	4	f.g.j	f.g.j	NOUN
admet-2802	361	5	.	.	PUNCT
admet-2802	361	6	poelma	poelma	PROPN
admet-2802	361	7	,	,	PUNCT
admet-2802	361	8	r.	r.	PROPN
admet-2802	361	9	breäs	breäs	PROPN
admet-2802	361	10	,	,	PUNCT
admet-2802	361	11	j.j	j.j	PROPN
admet-2802	361	12	.	.	PROPN
admet-2802	361	13	tukker	tukker	PROPN
admet-2802	361	14	,	,	PUNCT
admet-2802	361	15	d.j.a	d.j.a	PROPN
admet-2802	361	16	.	.	PUNCT
admet-2802	361	17	crommelin	crommelin	PROPN
admet-2802	361	18	.	.	PUNCT
admet-2802	362	1	intestinal	intestinal	ADJ
admet-2802	362	2	absorption	absorption	NOUN
admet-2802	362	3	of	of	ADP
admet-2802	362	4	drugs	drug	NOUN
admet-2802	362	5	.	.	PUNCT
admet-2802	363	1	the	the	DET
admet-2802	363	2	influence	influence	NOUN
admet-2802	363	3	of	of	ADP
admet-2802	363	4	mixed	mixed	ADJ
admet-2802	363	5	micelles	micelle	NOUN
admet-2802	363	6	on	on	ADP
admet-2802	363	7	on	on	ADP
admet-2802	363	8	the	the	DET
admet-2802	363	9	disappearance	disappearance	NOUN
admet-2802	363	10	kinetics	kinetic	NOUN
admet-2802	363	11	of	of	ADP
admet-2802	363	12	drugs	drug	NOUN
admet-2802	363	13	from	from	ADP
admet-2802	363	14	the	the	DET
admet-2802	363	15	small	small	ADJ
admet-2802	363	16	intestine	intestine	NOUN
admet-2802	363	17	of	of	ADP
admet-2802	363	18	the	the	DET
admet-2802	363	19	rat	rat	PROPN
admet-2802	363	20	.	.	PROPN
admet-2802	363	21	journal	journal	PROPN
admet-2802	363	22	of	of	ADP
admet-2802	363	23	pharmacy	pharmacy	NOUN
admet-2802	363	24	and	and	CCONJ
admet-2802	363	25	pharmacology	pharmacology	NOUN
admet-2802	363	26	43	43	NUM
admet-2802	363	27	(	(	PUNCT
admet-2802	363	28	1991	1991	NUM
admet-2802	363	29	)	)	PUNCT
admet-2802	363	30	317	317	NUM
admet-2802	363	31	-	-	SYM
admet-2802	363	32	324	324	NUM
admet-2802	363	33	.	.	PUNCT
admet-2802	364	1	https://doi.org/10.1111/j.20427158.1991.tb06697.x	https://doi.org/10.1111/j.20427158.1991.tb06697.x	PUNCT
admet-2802	365	1	[	[	X
admet-2802	365	2	10	10	NUM
admet-2802	365	3	]	]	X
admet-2802	365	4	f.	f.	PROPN
admet-2802	365	5	ingels	ingels	PROPN
admet-2802	365	6	,	,	PUNCT
admet-2802	365	7	b.	b.	PROPN
admet-2802	365	8	beck	beck	PROPN
admet-2802	365	9	,	,	PUNCT
admet-2802	365	10	m.	m.	PROPN
admet-2802	365	11	oth	oth	PROPN
admet-2802	365	12	,	,	PUNCT
admet-2802	365	13	p.	p.	NOUN
admet-2802	365	14	augustijns	augustijns	NOUN
admet-2802	365	15	.	.	PUNCT
admet-2802	366	1	effect	effect	NOUN
admet-2802	366	2	of	of	ADP
admet-2802	366	3	simulated	simulated	ADJ
admet-2802	366	4	intestinal	intestinal	ADJ
admet-2802	366	5	fluid	fluid	NOUN
admet-2802	366	6	on	on	ADP
admet-2802	366	7	drug	drug	NOUN
admet-2802	366	8	permeability	permeability	NOUN
admet-2802	366	9	estimation	estimation	NOUN
admet-2802	366	10	across	across	ADP
admet-2802	366	11	caco-2	caco-2	NUM
admet-2802	366	12	monolayers	monolayer	NOUN
admet-2802	366	13	.	.	PUNCT
admet-2802	367	1	international	international	ADJ
admet-2802	367	2	journal	journal	PROPN
admet-2802	367	3	of	of	ADP
admet-2802	367	4	pharmaceutics	pharmaceutic	NOUN
admet-2802	367	5	274	274	NUM
admet-2802	367	6	(	(	PUNCT
admet-2802	367	7	2004	2004	NUM
admet-2802	367	8	)	)	PUNCT
admet-2802	367	9	221	221	NUM
admet-2802	367	10	-	-	SYM
admet-2802	367	11	232	232	NUM
admet-2802	368	1	[	[	X
admet-2802	368	2	11	11	NUM
admet-2802	368	3	]	]	PUNCT
admet-2802	368	4	a.	a.	NOUN
admet-2802	368	5	glomme	glomme	PROPN
admet-2802	368	6	,	,	PUNCT
admet-2802	368	7	j.	j.	PROPN
admet-2802	368	8	mrz	mrz	PROPN
admet-2802	368	9	,	,	PUNCT
admet-2802	368	10	j.b	j.b	PROPN
admet-2802	368	11	.	.	PROPN
admet-2802	368	12	dressman	dressman	PROPN
admet-2802	368	13	.	.	PUNCT
admet-2802	369	1	predicting	predict	VERB
admet-2802	369	2	the	the	DET
admet-2802	369	3	intestinal	intestinal	ADJ
admet-2802	369	4	solubility	solubility	NOUN
admet-2802	369	5	of	of	ADP
admet-2802	369	6	poorly	poorly	ADV
admet-2802	369	7	soluble	soluble	ADJ
admet-2802	369	8	drugs	drug	NOUN
admet-2802	369	9	.	.	PUNCT
admet-2802	370	1	in	in	ADP
admet-2802	370	2	:	:	PUNCT
admet-2802	370	3	b.	b.	PROPN
admet-2802	370	4	testa	testa	PROPN
admet-2802	370	5	,	,	PUNCT
admet-2802	370	6	s.d	s.d	PROPN
admet-2802	370	7	.	.	PROPN
admet-2802	370	8	krmer	krmer	PROPN
admet-2802	370	9	,	,	PUNCT
admet-2802	370	10	h.	h.	PROPN
admet-2802	370	11	wunderli	wunderli	NOUN
admet-2802	370	12	-	-	PUNCT
admet-2802	370	13	allenspach	allenspach	NOUN
admet-2802	370	14	,	,	PUNCT
admet-2802	370	15	g.	g.	PROPN
admet-2802	370	16	folkers	folker	NOUN
admet-2802	370	17	(	(	PUNCT
admet-2802	370	18	eds	ed	NOUN
admet-2802	370	19	.	.	PUNCT
admet-2802	370	20	)	)	PUNCT
admet-2802	370	21	,	,	PUNCT
admet-2802	370	22	pharmacokinetic	pharmacokinetic	ADJ
admet-2802	370	23	profiling	profiling	NOUN
admet-2802	370	24	in	in	ADP
admet-2802	370	25	drug	drug	NOUN
admet-2802	370	26	research	research	NOUN
admet-2802	370	27	,	,	PUNCT
admet-2802	370	28	wiley	wiley	PROPN
admet-2802	370	29	-	-	PUNCT
admet-2802	370	30	vch	vch	PROPN
admet-2802	370	31	verlag	verlag	PROPN
admet-2802	370	32	gmbh	gmbh	PROPN
admet-2802	370	33	&	&	CCONJ
admet-2802	370	34	co.	co.	PROPN
admet-2802	370	35	kgaa	kgaa	PROPN
admet-2802	370	36	,	,	PUNCT
admet-2802	370	37	weinheim	weinheim	PROPN
admet-2802	370	38	,	,	PUNCT
admet-2802	370	39	germany	germany	PROPN
admet-2802	370	40	,	,	PUNCT
admet-2802	370	41	2006	2006	NUM
admet-2802	370	42	:	:	PUNCT
admet-2802	370	43	pp	pp	ADP
admet-2802	370	44	.	.	PUNCT
admet-2802	371	1	259	259	NUM
admet-2802	371	2	-	-	SYM
admet-2802	371	3	280	280	NUM
admet-2802	371	4	.	.	PUNCT
admet-2802	372	1	https://doi.org/10.1002/9783906390468.ch16	https://doi.org/10.1002/9783906390468.ch16	PROPN
admet-2802	373	1	[	[	X
admet-2802	373	2	12	12	NUM
admet-2802	373	3	]	]	PUNCT
admet-2802	373	4	a.	a.	NOUN
admet-2802	373	5	avdeef	avdeef	PROPN
admet-2802	373	6	.	.	PUNCT
admet-2802	374	1	absorption	absorption	NOUN
admet-2802	374	2	and	and	CCONJ
admet-2802	374	3	drug	drug	NOUN
admet-2802	374	4	development	development	NOUN
admet-2802	374	5	:	:	PUNCT
admet-2802	374	6	solubility	solubility	NOUN
admet-2802	374	7	,	,	PUNCT
admet-2802	374	8	permeability	permeability	NOUN
admet-2802	374	9	,	,	PUNCT
admet-2802	374	10	and	and	CCONJ
admet-2802	374	11	charge	charge	NOUN
admet-2802	374	12	state	state	NOUN
admet-2802	374	13	,	,	PUNCT
admet-2802	374	14	second	second	ADJ
admet-2802	374	15	edition	edition	NOUN
admet-2802	374	16	,	,	PUNCT
admet-2802	374	17	john	john	PROPN
admet-2802	374	18	wiley	wiley	PROPN
admet-2802	374	19	&	&	CCONJ
admet-2802	374	20	sons	sons	PROPN
admet-2802	374	21	,	,	PUNCT
admet-2802	374	22	inc	inc	PROPN
admet-2802	374	23	.	.	PROPN
admet-2802	374	24	,	,	PUNCT
admet-2802	374	25	2012	2012	NUM
admet-2802	374	26	.	.	PUNCT
admet-2802	375	1	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	PRON
admet-2802	376	1	[	[	X
admet-2802	376	2	13	13	NUM
admet-2802	376	3	]	]	X
admet-2802	376	4	g.p	g.p	PROPN
admet-2802	376	5	.	.	PROPN
admet-2802	376	6	van	van	PROPN
admet-2802	376	7	balen	balen	PROPN
admet-2802	376	8	,	,	PUNCT
admet-2802	376	9	g.	g.	PROPN
admet-2802	376	10	caron	caron	PROPN
admet-2802	376	11	,	,	PUNCT
admet-2802	376	12	g.	g.	PROPN
admet-2802	376	13	ermondi	ermondi	PROPN
admet-2802	376	14	,	,	PUNCT
admet-2802	376	15	a.	a.	NOUN
admet-2802	376	16	pagliara	pagliara	PROPN
admet-2802	376	17	,	,	PUNCT
admet-2802	376	18	t.	t.	PROPN
admet-2802	376	19	grandi	grandi	PROPN
admet-2802	376	20	,	,	PUNCT
admet-2802	376	21	g.	g.	PROPN
admet-2802	376	22	bouchard	bouchard	PROPN
admet-2802	376	23	,	,	PUNCT
admet-2802	376	24	r.	r.	PROPN
admet-2802	376	25	fruttero	fruttero	PROPN
admet-2802	376	26	,	,	PUNCT
admet-2802	376	27	p.-a	p.-a	NOUN
admet-2802	376	28	.	.	PUNCT
admet-2802	377	1	carrupt	carrupt	PROPN
admet-2802	377	2	,	,	PUNCT
admet-2802	377	3	b.	b.	PROPN
admet-2802	377	4	testa	testa	PROPN
admet-2802	377	5	.	.	PUNCT
admet-2802	378	1	lipophilicity	lipophilicity	NOUN
admet-2802	378	2	behaviour	behaviour	NOUN
admet-2802	378	3	of	of	ADP
admet-2802	378	4	the	the	DET
admet-2802	378	5	zwitterionic	zwitterionic	ADJ
admet-2802	378	6	antihistamine	antihistamine	PROPN
admet-2802	378	7	cetirizine	cetirizine	NOUN
admet-2802	378	8	in	in	ADP
admet-2802	378	9	phosphatidylcholine	phosphatidylcholine	PROPN
admet-2802	378	10	https://doi.org/10.1021/mp100149j	https://doi.org/10.1021/mp100149j	PROPN
admet-2802	378	11	https://doi.org/10.1002/jps.24603	https://doi.org/10.1002/jps.24603	PROPN
admet-2802	378	12	https://doi.org/10.1208/s12248-025-01016-x	https://doi.org/10.1208/s12248-025-01016-x	PROPN
admet-2802	378	13	https://doi.org/10.1016/j.ejps.2020.105543	https://doi.org/10.1016/j.ejps.2020.105543	PROPN
admet-2802	378	14	https://doi.org/10.1016/j.ejps.2010.03.011	https://doi.org/10.1016/j.ejps.2010.03.011	PROPN
admet-2802	378	15	https://doi.org/10.1016/j.ijpharm.2014.12.021	https://doi.org/10.1016/j.ijpharm.2014.12.021	NOUN
admet-2802	378	16	https://doi.org/10.1016/j.ejps.2014.11.010	https://doi.org/10.1016/j.ejps.2014.11.010	NOUN
admet-2802	378	17	https://doi.org/10.1248/cpb.34.3362	https://doi.org/10.1248/cpb.34.3362	PRON
admet-2802	378	18	https://doi.org/10.1111/j.2042-7158.1991.tb06697.x	https://doi.org/10.1111/j.2042-7158.1991.tb06697.x	PROPN
admet-2802	379	1	https://doi.org/10.1111/j.2042-7158.1991.tb06697.x	https://doi.org/10.1111/j.2042-7158.1991.tb06697.x	PROPN
admet-2802	379	2	https://doi.org/10.1002/9783906390468.ch16	https://doi.org/10.1002/9783906390468.ch16	PROPN
admet-2802	379	3	https://doi.org/10.1002/9781118286067	https://doi.org/10.1002/9781118286067	PRON
admet-2802	379	4	admet	admet	PROPN
admet-2802	379	5	&	&	CCONJ
admet-2802	379	6	dmpk	dmpk	PROPN
admet-2802	379	7	13(4	13(4	NUM
admet-2802	379	8	)	)	PUNCT
admet-2802	379	9	(	(	PUNCT
admet-2802	379	10	2025	2025	NUM
admet-2802	379	11	)	)	PUNCT
admet-2802	379	12	2802	2802	NUM
admet-2802	379	13	bile	bile	NOUN
admet-2802	379	14	micelle	micelle	NOUN
admet-2802	379	15	binding	bind	VERB
admet-2802	379	16	of	of	ADP
admet-2802	379	17	structurally	structurally	ADV
admet-2802	379	18	diverse	diverse	ADJ
admet-2802	379	19	ionized	ionized	ADJ
admet-2802	379	20	drugs	drug	NOUN
admet-2802	379	21	doi	doi	NOUN
admet-2802	379	22	:	:	PUNCT
admet-2802	379	23	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	379	24	11	11	NUM
admet-2802	379	25	liposomes	liposome	NOUN
admet-2802	379	26	/	/	SYM
admet-2802	379	27	water	water	NOUN
admet-2802	379	28	systems	system	NOUN
admet-2802	379	29	.	.	PUNCT
admet-2802	380	1	pharmaceutical	pharmaceutical	PROPN
admet-2802	380	2	research	research	NOUN
admet-2802	380	3	18	18	NUM
admet-2802	380	4	(	(	PUNCT
admet-2802	380	5	2001	2001	NUM
admet-2802	380	6	)	)	PUNCT
admet-2802	380	7	694	694	NUM
admet-2802	380	8	-	-	SYM
admet-2802	380	9	701	701	NUM
admet-2802	380	10	.	.	PUNCT
admet-2802	381	1	https://doi.org/10.1023/a:1011049830615	https://doi.org/10.1023/a:1011049830615	PROPN
admet-2802	381	2	[	[	X
admet-2802	381	3	14	14	NUM
admet-2802	381	4	]	]	PUNCT
admet-2802	381	5	a.	a.	NOUN
admet-2802	381	6	avdeef	avdeef	PROPN
admet-2802	381	7	,	,	PUNCT
admet-2802	381	8	k.j	k.j	PROPN
admet-2802	381	9	.	.	PROPN
admet-2802	381	10	box	box	PROPN
admet-2802	381	11	,	,	PUNCT
admet-2802	381	12	j.e.a	j.e.a	PROPN
admet-2802	381	13	.	.	PUNCT
admet-2802	381	14	comer	comer	PROPN
admet-2802	381	15	,	,	PUNCT
admet-2802	381	16	c.	c.	PROPN
admet-2802	381	17	hibbert	hibbert	PROPN
admet-2802	381	18	,	,	PUNCT
admet-2802	381	19	k.y	k.y	PROPN
admet-2802	381	20	.	.	PROPN
admet-2802	381	21	tam	tam	PROPN
admet-2802	381	22	.	.	PUNCT
admet-2802	381	23	ph	ph	ADJ
admet-2802	381	24	-	-	ADJ
admet-2802	381	25	metric	metric	ADJ
admet-2802	381	26	logp	logp	NOUN
admet-2802	381	27	10	10	NUM
admet-2802	381	28	.	.	PUNCT
admet-2802	382	1	determination	determination	NOUN
admet-2802	382	2	of	of	ADP
admet-2802	382	3	liposomal	liposomal	ADJ
admet-2802	382	4	membrane	membrane	NOUN
admet-2802	382	5	-	-	PUNCT
admet-2802	382	6	water	water	NOUN
admet-2802	382	7	partition	partition	NOUN
admet-2802	382	8	coefficients	coefficient	NOUN
admet-2802	382	9	of	of	ADP
admet-2802	382	10	lonizable	lonizable	ADJ
admet-2802	382	11	drugs	drug	NOUN
admet-2802	382	12	.	.	PUNCT
admet-2802	383	1	pharmaceutical	pharmaceutical	ADJ
admet-2802	383	2	research	research	NOUN
admet-2802	383	3	15	15	NUM
admet-2802	383	4	(	(	PUNCT
admet-2802	383	5	1998	1998	NUM
admet-2802	383	6	)	)	PUNCT
admet-2802	383	7	209215	209215	NUM
admet-2802	383	8	.	.	PUNCT
admet-2802	384	1	https://doi.org/10.1023/a:1011954332221	https://doi.org/10.1023/a:1011954332221	NOUN
admet-2802	384	2	[	[	X
admet-2802	384	3	15	15	NUM
admet-2802	384	4	]	]	X
admet-2802	384	5	m.a	m.a	PROPN
admet-2802	384	6	.	.	PROPN
admet-2802	384	7	schwarz	schwarz	PROPN
admet-2802	384	8	,	,	PUNCT
admet-2802	384	9	r.h.h	r.h.h	NOUN
admet-2802	384	10	.	.	PUNCT
admet-2802	385	1	neubert	neubert	PROPN
admet-2802	385	2	,	,	PUNCT
admet-2802	385	3	g.	g.	PROPN
admet-2802	385	4	dongowski	dongowski	PROPN
admet-2802	385	5	.	.	PUNCT
admet-2802	386	1	characterization	characterization	NOUN
admet-2802	386	2	of	of	ADP
admet-2802	386	3	interactions	interaction	NOUN
admet-2802	386	4	between	between	ADP
admet-2802	386	5	bile	bile	NOUN
admet-2802	386	6	salts	salt	NOUN
admet-2802	386	7	and	and	CCONJ
admet-2802	386	8	drugs	drug	NOUN
admet-2802	386	9	by	by	ADP
admet-2802	386	10	micellar	micellar	ADJ
admet-2802	386	11	electrokinetic	electrokinetic	ADJ
admet-2802	386	12	capillary	capillary	ADJ
admet-2802	386	13	chromatography	chromatography	NOUN
admet-2802	386	14	.	.	PUNCT
admet-2802	387	1	part	part	PROPN
admet-2802	387	2	i.	i.	PROPN
admet-2802	387	3	pharmaceutical	pharmaceutical	PROPN
admet-2802	387	4	research	research	PROPN
admet-2802	387	5	13	13	NUM
admet-2802	387	6	(	(	PUNCT
admet-2802	387	7	1996	1996	NUM
admet-2802	387	8	)	)	PUNCT
admet-2802	387	9	1174	1174	NUM
admet-2802	387	10	-	-	SYM
admet-2802	387	11	1180	1180	NUM
admet-2802	387	12	.	.	PUNCT
admet-2802	388	1	https://doi.org/10.1023/a:1016051917608	https://doi.org/10.1023/a:1016051917608	NOUN
admet-2802	388	2	[	[	X
admet-2802	388	3	16	16	NUM
admet-2802	388	4	]	]	X
admet-2802	388	5	b.d	b.d	PROPN
admet-2802	388	6	.	.	PROPN
admet-2802	388	7	castro	castro	PROPN
admet-2802	388	8	,	,	PUNCT
admet-2802	388	9	p.	p.	PROPN
admet-2802	388	10	gameiro	gameiro	PROPN
admet-2802	388	11	,	,	PUNCT
admet-2802	388	12	c.	c.	PROPN
admet-2802	388	13	guimarães	guimarães	PROPN
admet-2802	388	14	,	,	PUNCT
admet-2802	388	15	j.l.f.c	j.l.f.c	PROPN
admet-2802	388	16	.	.	PROPN
admet-2802	388	17	lima	lima	PROPN
admet-2802	388	18	,	,	PUNCT
admet-2802	388	19	s.	s.	PROPN
admet-2802	388	20	reis	reis	PROPN
admet-2802	388	21	.	.	PUNCT
admet-2802	389	1	partition	partition	NOUN
admet-2802	389	2	coefficients	coefficient	NOUN
admet-2802	389	3	of	of	ADP
admet-2802	389	4	β	β	NOUN
admet-2802	389	5	-	-	NOUN
admet-2802	389	6	blockers	blocker	NOUN
admet-2802	389	7	in	in	ADP
admet-2802	389	8	bile	bile	NOUN
admet-2802	389	9	salt	salt	NOUN
admet-2802	389	10	/	/	SYM
admet-2802	389	11	lecithin	lecithin	NOUN
admet-2802	389	12	micelles	micelle	NOUN
admet-2802	389	13	as	as	ADP
admet-2802	389	14	a	a	DET
admet-2802	389	15	tool	tool	NOUN
admet-2802	389	16	to	to	PART
admet-2802	389	17	assess	assess	VERB
admet-2802	389	18	the	the	DET
admet-2802	389	19	role	role	NOUN
admet-2802	389	20	of	of	ADP
admet-2802	389	21	mixed	mixed	ADJ
admet-2802	389	22	micelles	micelle	NOUN
admet-2802	389	23	in	in	ADP
admet-2802	389	24	gastrointestinal	gastrointestinal	ADJ
admet-2802	389	25	absorption	absorption	NOUN
admet-2802	389	26	.	.	PUNCT
admet-2802	390	1	biophysical	biophysical	ADJ
admet-2802	390	2	chemistry	chemistry	NOUN
admet-2802	390	3	90	90	NUM
admet-2802	390	4	(	(	PUNCT
admet-2802	390	5	2001	2001	NUM
admet-2802	390	6	)	)	PUNCT
admet-2802	390	7	31	31	NUM
admet-2802	390	8	-	-	SYM
admet-2802	390	9	43	43	NUM
admet-2802	390	10	.	.	PUNCT
admet-2802	391	1	https://doi.org/10.1016/s0301-4622(01)00126-0	https://doi.org/10.1016/s0301-4622(01)00126-0	PROPN
admet-2802	392	1	[	[	X
admet-2802	392	2	17	17	NUM
admet-2802	392	3	]	]	PUNCT
admet-2802	392	4	s.	s.	PROPN
admet-2802	392	5	modi	modi	PROPN
admet-2802	392	6	,	,	PUNCT
admet-2802	392	7	b.d	b.d	PROPN
admet-2802	392	8	.	.	PROPN
admet-2802	392	9	anderson	anderson	PROPN
admet-2802	392	10	.	.	PUNCT
admet-2802	393	1	determination	determination	NOUN
admet-2802	393	2	of	of	ADP
admet-2802	393	3	drug	drug	NOUN
admet-2802	393	4	release	release	NOUN
admet-2802	393	5	kinetics	kinetic	NOUN
admet-2802	393	6	from	from	ADP
admet-2802	393	7	nanoparticles	nanoparticle	NOUN
admet-2802	393	8	:	:	PUNCT
admet-2802	393	9	overcoming	overcome	VERB
admet-2802	393	10	pitfalls	pitfall	NOUN
admet-2802	393	11	of	of	ADP
admet-2802	393	12	the	the	DET
admet-2802	393	13	dynamic	dynamic	ADJ
admet-2802	393	14	dialysis	dialysis	NOUN
admet-2802	393	15	method	method	NOUN
admet-2802	393	16	.	.	PUNCT
admet-2802	394	1	molecular	molecular	ADJ
admet-2802	394	2	pharmaceutics	pharmaceutic	NOUN
admet-2802	394	3	10	10	NUM
admet-2802	394	4	(	(	PUNCT
admet-2802	394	5	2013	2013	NUM
admet-2802	394	6	)	)	PUNCT
admet-2802	394	7	3076	3076	NUM
admet-2802	394	8	-	-	SYM
admet-2802	394	9	3089	3089	NUM
admet-2802	394	10	.	.	PUNCT
admet-2802	395	1	https://doi.org/10.1021/mp400154a	https://doi.org/10.1021/mp400154a	PROPN
admet-2802	396	1	[	[	X
admet-2802	396	2	18	18	NUM
admet-2802	396	3	]	]	PUNCT
admet-2802	396	4	k.	k.	PROPN
admet-2802	396	5	yano	yano	PROPN
admet-2802	396	6	,	,	PUNCT
admet-2802	396	7	y.	y.	PROPN
admet-2802	396	8	masaoka	masaoka	PROPN
admet-2802	396	9	,	,	PUNCT
admet-2802	396	10	m.	m.	NOUN
admet-2802	396	11	kataoka	kataoka	PROPN
admet-2802	396	12	,	,	PUNCT
admet-2802	396	13	s.	s.	PROPN
admet-2802	396	14	sakuma	sakuma	PROPN
admet-2802	396	15	,	,	PUNCT
admet-2802	396	16	s.	s.	PROPN
admet-2802	396	17	yamashita	yamashita	PROPN
admet-2802	396	18	.	.	PUNCT
admet-2802	397	1	mechanisms	mechanism	NOUN
admet-2802	397	2	of	of	ADP
admet-2802	397	3	membrane	membrane	NOUN
admet-2802	397	4	transport	transport	NOUN
admet-2802	397	5	of	of	ADP
admet-2802	397	6	poorly	poorly	ADV
admet-2802	397	7	soluble	soluble	ADJ
admet-2802	397	8	drugs	drug	NOUN
admet-2802	397	9	:	:	PUNCT
admet-2802	397	10	role	role	NOUN
admet-2802	397	11	of	of	ADP
admet-2802	397	12	micelles	micelle	NOUN
admet-2802	397	13	in	in	ADP
admet-2802	397	14	oral	oral	ADJ
admet-2802	397	15	absorption	absorption	NOUN
admet-2802	397	16	processes	process	NOUN
admet-2802	397	17	.	.	PUNCT
admet-2802	398	1	journal	journal	NOUN
admet-2802	398	2	of	of	ADP
admet-2802	398	3	pharmaceutical	pharmaceutical	PROPN
admet-2802	398	4	sciences	science	NOUN
admet-2802	398	5	99	99	NUM
admet-2802	398	6	(	(	PUNCT
admet-2802	398	7	2010	2010	NUM
admet-2802	398	8	)	)	PUNCT
admet-2802	398	9	1336	1336	NUM
admet-2802	398	10	-	-	SYM
admet-2802	398	11	1345	1345	NUM
admet-2802	398	12	.	.	PUNCT
admet-2802	399	1	https://doi.org/10.1002/jps.21919	https://doi.org/10.1002/jps.21919	PROPN
admet-2802	400	1	[	[	X
admet-2802	400	2	19	19	NUM
admet-2802	400	3	]	]	PUNCT
admet-2802	400	4	a.	a.	NOUN
admet-2802	400	5	fuchs	fuchs	PROPN
admet-2802	400	6	,	,	PUNCT
admet-2802	400	7	m.	m.	NOUN
admet-2802	400	8	leigh	leigh	PROPN
admet-2802	400	9	,	,	PUNCT
admet-2802	400	10	b.	b.	PROPN
admet-2802	400	11	kloefer	kloefer	PROPN
admet-2802	400	12	,	,	PUNCT
admet-2802	400	13	j.b	j.b	PROPN
admet-2802	400	14	.	.	PROPN
admet-2802	400	15	dressman	dressman	PROPN
admet-2802	400	16	.	.	PUNCT
admet-2802	401	1	advances	advance	NOUN
admet-2802	401	2	in	in	ADP
admet-2802	401	3	the	the	DET
admet-2802	401	4	design	design	NOUN
admet-2802	401	5	of	of	ADP
admet-2802	401	6	fasted	fasted	ADJ
admet-2802	401	7	state	state	NOUN
admet-2802	401	8	simulating	simulate	VERB
admet-2802	401	9	intestinal	intestinal	ADJ
admet-2802	401	10	fluids	fluid	NOUN
admet-2802	401	11	:	:	PUNCT
admet-2802	401	12	fassif	fassif	NOUN
admet-2802	401	13	-	-	PUNCT
admet-2802	401	14	v3	v3	PROPN
admet-2802	401	15	.	.	PUNCT
admet-2802	402	1	european	european	PROPN
admet-2802	402	2	journal	journal	PROPN
admet-2802	402	3	of	of	ADP
admet-2802	402	4	pharmaceutics	pharmaceutic	NOUN
admet-2802	402	5	and	and	CCONJ
admet-2802	402	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2802	402	7	94	94	NUM
admet-2802	402	8	(	(	PUNCT
admet-2802	402	9	2015	2015	NUM
admet-2802	402	10	)	)	PUNCT
admet-2802	402	11	229240	229240	NUM
admet-2802	402	12	.	.	PUNCT
admet-2802	403	1	https://doi.org/10.1016/j.ejpb.2015.05.015	https://doi.org/10.1016/j.ejpb.2015.05.015	NUM
admet-2802	403	2	[	[	X
admet-2802	403	3	20	20	NUM
admet-2802	403	4	]	]	PUNCT
admet-2802	403	5	k.	k.	PROPN
admet-2802	403	6	box	box	PROPN
admet-2802	403	7	,	,	PUNCT
admet-2802	403	8	j.	j.	PROPN
admet-2802	403	9	comer	comer	PROPN
admet-2802	403	10	.	.	PUNCT
admet-2802	404	1	using	use	VERB
admet-2802	404	2	measured	measured	ADJ
admet-2802	404	3	pka	pka	PROPN
admet-2802	404	4	,	,	PUNCT
admet-2802	404	5	logp	logp	NOUN
admet-2802	404	6	and	and	CCONJ
admet-2802	404	7	solubility	solubility	NOUN
admet-2802	404	8	to	to	PART
admet-2802	404	9	investigate	investigate	VERB
admet-2802	404	10	supersaturation	supersaturation	NOUN
admet-2802	404	11	and	and	CCONJ
admet-2802	404	12	predict	predict	VERB
admet-2802	404	13	bcs	bcs	NOUN
admet-2802	404	14	class	class	NOUN
admet-2802	404	15	.	.	PUNCT
admet-2802	405	1	current	current	ADJ
admet-2802	405	2	drug	drug	NOUN
admet-2802	405	3	metabolism	metabolism	NOUN
admet-2802	405	4	9	9	NUM
admet-2802	405	5	(	(	PUNCT
admet-2802	405	6	2008	2008	NUM
admet-2802	405	7	)	)	PUNCT
admet-2802	405	8	869	869	NUM
admet-2802	405	9	-	-	SYM
admet-2802	405	10	878	878	NUM
admet-2802	405	11	.	.	PUNCT
admet-2802	406	1	https://doi.org/10.2174/138920008786485155	https://doi.org/10.2174/138920008786485155	X
admet-2802	407	1	[	[	X
admet-2802	407	2	21	21	NUM
admet-2802	407	3	]	]	PUNCT
admet-2802	407	4	t.	t.	NOUN
admet-2802	407	5	gramatté	gramatté	PROPN
admet-2802	407	6	,	,	PUNCT
admet-2802	407	7	r.	r.	PROPN
admet-2802	407	8	oertel	oertel	PROPN
admet-2802	407	9	,	,	PUNCT
admet-2802	407	10	b.	b.	PROPN
admet-2802	407	11	terhaag	terhaag	PROPN
admet-2802	407	12	,	,	PUNCT
admet-2802	407	13	w.	w.	PROPN
admet-2802	407	14	kirch	kirch	PROPN
admet-2802	407	15	.	.	PUNCT
admet-2802	408	1	direct	direct	ADJ
admet-2802	408	2	demonstration	demonstration	NOUN
admet-2802	408	3	of	of	ADP
admet-2802	408	4	small	small	ADJ
admet-2802	408	5	intestinal	intestinal	ADJ
admet-2802	408	6	secretion	secretion	NOUN
admet-2802	408	7	and	and	CCONJ
admet-2802	408	8	site	site	NOUN
admet-2802	408	9	-	-	PUNCT
admet-2802	408	10	dependent	dependent	ADJ
admet-2802	408	11	absorption	absorption	NOUN
admet-2802	408	12	of	of	ADP
admet-2802	408	13	the	the	DET
admet-2802	408	14	β	β	NOUN
admet-2802	408	15	-	-	NOUN
admet-2802	408	16	blocker	blocker	NOUN
admet-2802	408	17	talinolol	talinolol	NOUN
admet-2802	408	18	in	in	ADP
admet-2802	408	19	humans	human	NOUN
admet-2802	408	20	.	.	PUNCT
admet-2802	409	1	clinical	clinical	ADJ
admet-2802	409	2	pharmacology	pharmacology	NOUN
admet-2802	409	3	and	and	CCONJ
admet-2802	409	4	therapeutics	therapeutic	NOUN
admet-2802	409	5	59	59	NUM
admet-2802	409	6	(	(	PUNCT
admet-2802	409	7	1996	1996	NUM
admet-2802	409	8	)	)	PUNCT
admet-2802	410	1	541	541	NUM
admet-2802	410	2	-	-	SYM
admet-2802	410	3	549	549	NUM
admet-2802	410	4	.	.	PUNCT
admet-2802	410	5	https://doi.org/10.1016/s0009-9236(96)90182-4	https://doi.org/10.1016/s0009-9236(96)90182-4	PROPN
admet-2802	410	6	[	[	X
admet-2802	410	7	22	22	NUM
admet-2802	410	8	]	]	X
admet-2802	410	9	astellas	astellas	PROPN
admet-2802	410	10	pharma	pharma	PROPN
admet-2802	410	11	inc	inc	PROPN
admet-2802	410	12	.	.	PROPN
admet-2802	410	13	tamsulosin	tamsulosin	PROPN
admet-2802	410	14	drug	drug	NOUN
admet-2802	410	15	product	product	NOUN
admet-2802	410	16	infomation	infomation	NOUN
admet-2802	410	17	.	.	PUNCT
admet-2802	411	1	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202	PROPN
admet-2802	411	2	412103_y.pdf	412103_y.pdf	NUM
admet-2802	411	3	.	.	PUNCT
admet-2802	412	1	[	[	X
admet-2802	412	2	23	23	NUM
admet-2802	412	3	]	]	X
admet-2802	412	4	kyorin	kyorin	PROPN
admet-2802	412	5	pharmaceutical	pharmaceutical	PROPN
admet-2802	412	6	co.	co.	PROPN
admet-2802	412	7	,	,	PUNCT
admet-2802	412	8	ltd	ltd	PROPN
admet-2802	412	9	.	.	PROPN
admet-2802	412	10	beova	beova	PROPN
admet-2802	412	11	drug	drug	NOUN
admet-2802	412	12	product	product	NOUN
admet-2802	412	13	information	information	NOUN
admet-2802	412	14	.	.	PUNCT
admet-2802	413	1	https://www.kyorinpharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	https://www.kyorinpharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	NOUN
admet-2802	413	2	.	.	PUNCT
admet-2802	414	1	[	[	X
admet-2802	414	2	24	24	NUM
admet-2802	414	3	]	]	X
admet-2802	414	4	kyowa	kyowa	PROPN
admet-2802	414	5	kirin	kirin	PROPN
admet-2802	414	6	co.	co.	PROPN
admet-2802	414	7	,	,	PUNCT
admet-2802	414	8	ltd	ltd	PROPN
admet-2802	414	9	.	.	PROPN
admet-2802	414	10	olopatadine	olopatadine	PROPN
admet-2802	414	11	drug	drug	NOUN
admet-2802	414	12	product	product	NOUN
admet-2802	414	13	information	information	NOUN
admet-2802	414	14	.	.	PUNCT
admet-2802	415	1	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	NOUN
admet-2802	415	2	.	.	PUNCT
admet-2802	416	1	[	[	X
admet-2802	416	2	25	25	NUM
admet-2802	416	3	]	]	PUNCT
admet-2802	416	4	r.	r.	PROPN
admet-2802	416	5	takeuchi	takeuchi	PROPN
admet-2802	416	6	,	,	PUNCT
admet-2802	416	7	k.	k.	PROPN
admet-2802	416	8	sugano	sugano	PROPN
admet-2802	416	9	.	.	PUNCT
admet-2802	417	1	food	food	NOUN
admet-2802	417	2	and	and	CCONJ
admet-2802	417	3	bile	bile	NOUN
admet-2802	417	4	micelle	micelle	NOUN
admet-2802	417	5	binding	bind	VERB
admet-2802	417	6	of	of	ADP
admet-2802	417	7	zwitterionic	zwitterionic	ADJ
admet-2802	417	8	antihistamine	antihistamine	NOUN
admet-2802	417	9	drugs	drug	NOUN
admet-2802	417	10	.	.	PUNCT
admet-2802	418	1	admet	admet	PROPN
admet-2802	418	2	and	and	CCONJ
admet-2802	418	3	dmpk	dmpk	PROPN
admet-2802	418	4	12	12	NUM
admet-2802	418	5	(	(	PUNCT
admet-2802	418	6	2024	2024	NUM
admet-2802	418	7	)	)	PUNCT
admet-2802	418	8	649	649	NUM
admet-2802	418	9	-	-	SYM
admet-2802	418	10	656	656	NUM
admet-2802	418	11	.	.	PUNCT
admet-2802	419	1	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2802	419	2	[	[	X
admet-2802	419	3	26	26	NUM
admet-2802	419	4	]	]	PUNCT
admet-2802	419	5	t.	t.	NOUN
admet-2802	419	6	sumiji	sumiji	PROPN
admet-2802	419	7	,	,	PUNCT
admet-2802	419	8	k.	k.	PROPN
admet-2802	419	9	sugano	sugano	PROPN
admet-2802	419	10	.	.	PUNCT
admet-2802	420	1	food	food	NOUN
admet-2802	420	2	and	and	CCONJ
admet-2802	420	3	bile	bile	NOUN
admet-2802	420	4	micelle	micelle	NOUN
admet-2802	420	5	binding	bind	VERB
admet-2802	420	6	of	of	ADP
admet-2802	420	7	quaternary	quaternary	ADJ
admet-2802	420	8	ammonium	ammonium	NOUN
admet-2802	420	9	compounds	compound	NOUN
admet-2802	420	10	.	.	PUNCT
admet-2802	421	1	admet	admet	PROPN
admet-2802	421	2	and	and	CCONJ
admet-2802	421	3	dmpk	dmpk	X
admet-2802	421	4	11	11	NUM
admet-2802	421	5	(	(	PUNCT
admet-2802	421	6	2023	2023	NUM
admet-2802	421	7	)	)	PUNCT
admet-2802	421	8	409	409	NUM
admet-2802	421	9	-	-	SYM
admet-2802	421	10	417	417	NUM
admet-2802	421	11	.	.	PUNCT
admet-2802	421	12	https://doi.org/10.5599/admet.2023	https://doi.org/10.5599/admet.2023	X
admet-2802	422	1	[	[	X
admet-2802	422	2	27	27	NUM
admet-2802	422	3	]	]	PUNCT
admet-2802	422	4	k.	k.	PROPN
admet-2802	422	5	sugano	sugano	PROPN
admet-2802	422	6	.	.	PUNCT
admet-2802	423	1	biopharmaceutics	biopharmaceutics	NOUN
admet-2802	423	2	modeling	modeling	NOUN
admet-2802	423	3	and	and	CCONJ
admet-2802	423	4	simulations	simulation	NOUN
admet-2802	423	5	:	:	PUNCT
admet-2802	424	1	theory	theory	NOUN
admet-2802	424	2	,	,	PUNCT
admet-2802	424	3	practice	practice	NOUN
admet-2802	424	4	,	,	PUNCT
admet-2802	424	5	methods	method	NOUN
admet-2802	424	6	,	,	PUNCT
admet-2802	424	7	and	and	CCONJ
admet-2802	424	8	applications	application	NOUN
admet-2802	424	9	,	,	PUNCT
admet-2802	424	10	john	john	PROPN
admet-2802	424	11	wiley	wiley	PROPN
admet-2802	424	12	&	&	CCONJ
admet-2802	424	13	sons	son	NOUN
admet-2802	424	14	,	,	PUNCT
admet-2802	424	15	2012	2012	NUM
admet-2802	424	16	.	.	PUNCT
admet-2802	425	1	isbn	isbn	ADJ
admet-2802	425	2	:	:	PUNCT
admet-2802	425	3	978	978	NUM
admet-2802	425	4	-	-	SYM
admet-2802	425	5	1	1	NUM
admet-2802	425	6	-	-	NUM
admet-2802	425	7	118	118	NUM
admet-2802	425	8	-	-	PUNCT
admet-2802	425	9	35432	35432	NUM
admet-2802	425	10	-	-	SYM
admet-2802	425	11	2	2	NUM
admet-2802	425	12	[	[	SYM
admet-2802	425	13	28	28	NUM
admet-2802	425	14	]	]	X
admet-2802	425	15	n.	n.	PROPN
admet-2802	425	16	sun	sun	PROPN
admet-2802	425	17	,	,	PUNCT
admet-2802	425	18	a.	a.	NOUN
admet-2802	425	19	avdeef	avdeef	PROPN
admet-2802	425	20	.	.	PUNCT
admet-2802	426	1	biorelevant	biorelevant	PROPN
admet-2802	426	2	pk	pk	PROPN
admet-2802	426	3	a	a	X
admet-2802	426	4	(	(	PUNCT
admet-2802	426	5	37	37	NUM
admet-2802	426	6	°	°	NOUN
admet-2802	426	7	c	c	NOUN
admet-2802	426	8	)	)	PUNCT
admet-2802	426	9	predicted	predict	VERB
admet-2802	426	10	from	from	ADP
admet-2802	426	11	the	the	DET
admet-2802	426	12	2d	2d	NUM
admet-2802	426	13	structure	structure	NOUN
admet-2802	426	14	of	of	ADP
admet-2802	426	15	the	the	DET
admet-2802	426	16	molecule	molecule	NOUN
admet-2802	426	17	and	and	CCONJ
admet-2802	426	18	its	its	PRON
admet-2802	426	19	pk	pk	NOUN
admet-2802	426	20	a	a	PRON
admet-2802	426	21	at	at	ADP
admet-2802	426	22	25	25	NUM
admet-2802	426	23	°	°	NOUN
admet-2802	426	24	c	c	NOUN
admet-2802	426	25	.	.	PUNCT
admet-2802	427	1	journal	journal	PROPN
admet-2802	427	2	of	of	ADP
admet-2802	427	3	pharmaceutical	pharmaceutical	NOUN
admet-2802	427	4	and	and	CCONJ
admet-2802	427	5	biomedical	biomedical	ADJ
admet-2802	427	6	analysis	analysis	NOUN
admet-2802	427	7	56	56	NUM
admet-2802	427	8	(	(	PUNCT
admet-2802	427	9	2011	2011	NUM
admet-2802	427	10	)	)	PUNCT
admet-2802	427	11	173	173	NUM
admet-2802	427	12	-	-	SYM
admet-2802	427	13	182	182	NUM
admet-2802	427	14	.	.	PUNCT
admet-2802	428	1	https://doi.org/10.1016/j.jpba.2011.05.007	https://doi.org/10.1016/j.jpba.2011.05.007	VERB
admet-2802	428	2	[	[	X
admet-2802	428	3	29	29	NUM
admet-2802	428	4	]	]	PUNCT
admet-2802	428	5	s.	s.	PROPN
admet-2802	428	6	reis	reis	PROPN
admet-2802	428	7	,	,	PUNCT
admet-2802	428	8	c.g	c.g	PROPN
admet-2802	428	9	.	.	PROPN
admet-2802	428	10	moutinho	moutinho	PROPN
admet-2802	428	11	,	,	PUNCT
admet-2802	428	12	e.	e.	PROPN
admet-2802	428	13	pereira	pereira	PROPN
admet-2802	428	14	,	,	PUNCT
admet-2802	428	15	b.	b.	PROPN
admet-2802	428	16	de	de	X
admet-2802	428	17	castro	castro	PROPN
admet-2802	428	18	,	,	PUNCT
admet-2802	428	19	p.	p.	PROPN
admet-2802	428	20	gameiro	gameiro	PROPN
admet-2802	428	21	,	,	PUNCT
admet-2802	428	22	j.l	j.l	PROPN
admet-2802	428	23	.	.	PROPN
admet-2802	428	24	lima	lima	PROPN
admet-2802	428	25	.	.	PUNCT
admet-2802	429	1	β	β	X
admet-2802	429	2	-	-	PUNCT
admet-2802	429	3	blockers	blocker	NOUN
admet-2802	429	4	and	and	CCONJ
admet-2802	429	5	benzodiazepines	benzodiazepine	VERB
admet-2802	429	6	location	location	NOUN
admet-2802	429	7	in	in	ADP
admet-2802	429	8	sds	sds	PROPN
admet-2802	429	9	and	and	CCONJ
admet-2802	429	10	bile	bile	NOUN
admet-2802	429	11	salt	salt	NOUN
admet-2802	429	12	micellar	micellar	NOUN
admet-2802	429	13	systems	system	NOUN
admet-2802	429	14	:	:	PUNCT
admet-2802	429	15	an	an	DET
admet-2802	429	16	esr	esr	PROPN
admet-2802	429	17	study	study	PROPN
admet-2802	429	18	.	.	PUNCT
admet-2802	430	1	journal	journal	NOUN
admet-2802	430	2	of	of	ADP
admet-2802	430	3	pharmaceutical	pharmaceutical	NOUN
admet-2802	430	4	and	and	CCONJ
admet-2802	430	5	biomedical	biomedical	ADJ
admet-2802	430	6	analysis	analysis	NOUN
admet-2802	430	7	45	45	NUM
admet-2802	430	8	(	(	PUNCT
admet-2802	430	9	2007	2007	NUM
admet-2802	430	10	)	)	PUNCT
admet-2802	430	11	62	62	NUM
admet-2802	430	12	-	-	SYM
admet-2802	430	13	69	69	NUM
admet-2802	430	14	.	.	PUNCT
admet-2802	431	1	https://doi.org/10.1016/j.jpba.2007.05.023	https://doi.org/10.1016/j.jpba.2007.05.023	NOUN
admet-2802	431	2	[	[	SYM
admet-2802	431	3	30	30	NUM
admet-2802	431	4	]	]	X
admet-2802	431	5	a.	a.	NOUN
admet-2802	431	6	pagliara	pagliara	PROPN
admet-2802	431	7	,	,	PUNCT
admet-2802	431	8	p.a	p.a	PROPN
admet-2802	431	9	.	.	PROPN
admet-2802	431	10	carrupt	carrupt	PROPN
admet-2802	431	11	,	,	PUNCT
admet-2802	431	12	g.	g.	PROPN
admet-2802	431	13	caron	caron	PROPN
admet-2802	431	14	,	,	PUNCT
admet-2802	431	15	p.	p.	PROPN
admet-2802	431	16	gaillard	gaillard	PROPN
admet-2802	431	17	,	,	PUNCT
admet-2802	431	18	b.	b.	PROPN
admet-2802	431	19	testa	testa	PROPN
admet-2802	431	20	.	.	PUNCT
admet-2802	432	1	lipophilicity	lipophilicity	NOUN
admet-2802	432	2	profiles	profile	NOUN
admet-2802	432	3	of	of	ADP
admet-2802	432	4	ampholytes	ampholyte	NOUN
admet-2802	432	5	.	.	PUNCT
admet-2802	433	1	chemical	chemical	ADJ
admet-2802	433	2	reviews	review	NOUN
admet-2802	433	3	97	97	NUM
admet-2802	433	4	(	(	PUNCT
admet-2802	433	5	1997	1997	NUM
admet-2802	433	6	)	)	PUNCT
admet-2802	433	7	3385	3385	NUM
admet-2802	433	8	-	-	SYM
admet-2802	433	9	3400	3400	NUM
admet-2802	433	10	.	.	PUNCT
admet-2802	434	1	https://doi.org/10.1021/cr9601019	https://doi.org/10.1021/cr9601019	PRON
admet-2802	435	1	[	[	X
admet-2802	435	2	31	31	NUM
admet-2802	435	3	]	]	PUNCT
admet-2802	435	4	a.	a.	NOUN
admet-2802	435	5	ebert	ebert	PROPN
admet-2802	435	6	,	,	PUNCT
admet-2802	435	7	c.	c.	PROPN
admet-2802	435	8	dahley	dahley	PROPN
admet-2802	435	9	.	.	PUNCT
admet-2802	435	10	can	can	AUX
admet-2802	435	11	membrane	membrane	VERB
admet-2802	435	12	permeability	permeability	NOUN
admet-2802	435	13	of	of	ADP
admet-2802	435	14	zwitterionic	zwitterionic	ADJ
admet-2802	435	15	compounds	compound	NOUN
admet-2802	435	16	be	be	AUX
admet-2802	435	17	predicted	predict	VERB
admet-2802	435	18	by	by	ADP
admet-2802	435	19	the	the	DET
admet-2802	435	20	solubility	solubility	NOUN
admet-2802	435	21	diffusion	diffusion	NOUN
admet-2802	435	22	model	model	NOUN
admet-2802	435	23	?	?	PUNCT
admet-2802	436	1	european	european	ADJ
admet-2802	436	2	journal	journal	PROPN
admet-2802	436	3	of	of	ADP
admet-2802	436	4	pharmaceutical	pharmaceutical	PROPN
admet-2802	436	5	sciences	science	NOUN
admet-2802	436	6	(	(	PUNCT
admet-2802	436	7	2024	2024	NUM
admet-2802	436	8	)	)	PUNCT
admet-2802	436	9	106819	106819	NUM
admet-2802	436	10	.	.	PUNCT
admet-2802	437	1	https://doi.org/10.1016/j.ejps.2024.106819	https://doi.org/10.1016/j.ejps.2024.106819	ADJ
admet-2802	437	2	https://doi.org/10.5599/admet.2802	https://doi.org/10.5599/admet.2802	NOUN
admet-2802	437	3	https://doi.org/10.1023/a:1011049830615	https://doi.org/10.1023/a:1011049830615	PROPN
admet-2802	437	4	https://doi.org/10.1023/a:1011954332221	https://doi.org/10.1023/a:1011954332221	NOUN
admet-2802	437	5	https://doi.org/10.1023/a:1016051917608	https://doi.org/10.1023/a:1016051917608	PROPN
admet-2802	437	6	https://doi.org/10.1016/s0301-4622(01)00126-0	https://doi.org/10.1016/s0301-4622(01)00126-0	PROPN
admet-2802	437	7	https://doi.org/10.1021/mp400154a	https://doi.org/10.1021/mp400154a	PROPN
admet-2802	437	8	https://doi.org/10.1002/jps.21919	https://doi.org/10.1002/jps.21919	PROPN
admet-2802	437	9	https://doi.org/10.1016/j.ejpb.2015.05.015	https://doi.org/10.1016/j.ejpb.2015.05.015	PROPN
admet-2802	437	10	https://doi.org/10.2174/138920008786485155	https://doi.org/10.2174/138920008786485155	PROPN
admet-2802	437	11	https://doi.org/10.1016/s0009-9236(96)90182-4	https://doi.org/10.1016/s0009-9236(96)90182-4	PROPN
admet-2802	437	12	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202412103_y.pdf	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202412103_y.pdf	PROPN
admet-2802	437	13	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202412103_y.pdf	https://amn.astellas.jp/common/pdfviewer.html/content/dam/jp/amn/jp/ja/di/doc/pdfs/docno202412103_y.pdf	PROPN
admet-2802	437	14	https://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	https://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	PROPN
admet-2802	437	15	https://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	https://www.kyorin-pharm.co.jp/prodinfo/medicine/pdf/i_beova.pdf	PROPN
admet-2802	437	16	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	https://medical.kyowakirin.co.jp/site/drugpdf/interv/alk_in.pdf	PROPN
admet-2802	437	17	https://doi.org/10.5599/admet.2454	https://doi.org/10.5599/admet.2454	NOUN
admet-2802	437	18	https://doi.org/10.5599/admet.2023	https://doi.org/10.5599/admet.2023	ADJ
admet-2802	437	19	https://doi.org/10.1016/j.jpba.2011.05.007	https://doi.org/10.1016/j.jpba.2011.05.007	NUM
admet-2802	437	20	https://doi.org/10.1016/j.jpba.2007.05.023	https://doi.org/10.1016/j.jpba.2007.05.023	PROPN
admet-2802	437	21	https://doi.org/10.1021/cr9601019	https://doi.org/10.1021/cr9601019	PROPN
admet-2802	437	22	https://doi.org/10.1016/j.ejps.2024.106819	https://doi.org/10.1016/j.ejps.2024.106819	PROPN
admet-2802	437	23	m.	m.	NOUN
admet-2802	437	24	konishi	konishi	PROPN
admet-2802	437	25	and	and	CCONJ
admet-2802	437	26	k.	k.	PROPN
admet-2802	437	27	sugano	sugano	PROPN
admet-2802	437	28	admet	admet	PROPN
admet-2802	437	29	&	&	CCONJ
admet-2802	437	30	dmpk	dmpk	PROPN
admet-2802	437	31	13(4	13(4	NUM
admet-2802	437	32	)	)	PUNCT
admet-2802	437	33	(	(	PUNCT
admet-2802	437	34	2025	2025	NUM
admet-2802	437	35	)	)	PUNCT
admet-2802	437	36	2802	2802	NUM
admet-2802	437	37	12	12	NUM
admet-2802	438	1	[	[	SYM
admet-2802	438	2	32	32	NUM
admet-2802	438	3	]	]	PUNCT
admet-2802	438	4	g.	g.	PROPN
admet-2802	438	5	dongowski	dongowski	PROPN
admet-2802	438	6	,	,	PUNCT
admet-2802	438	7	b.	b.	PROPN
admet-2802	438	8	fritzsch	fritzsch	PROPN
admet-2802	438	9	,	,	PUNCT
admet-2802	438	10	j.	j.	PROPN
admet-2802	438	11	giessler	giessler	PROPN
admet-2802	438	12	,	,	PUNCT
admet-2802	438	13	a.	a.	NOUN
admet-2802	438	14	härtl	härtl	PROPN
admet-2802	438	15	,	,	PUNCT
admet-2802	438	16	o.	o.	PROPN
admet-2802	438	17	kuhlmann	kuhlmann	PROPN
admet-2802	438	18	,	,	PUNCT
admet-2802	438	19	r.h.h	r.h.h	NOUN
admet-2802	438	20	.	.	PUNCT
admet-2802	439	1	neubert	neubert	PROPN
admet-2802	439	2	.	.	PUNCT
admet-2802	440	1	the	the	DET
admet-2802	440	2	influence	influence	NOUN
admet-2802	440	3	of	of	ADP
admet-2802	440	4	bile	bile	NOUN
admet-2802	440	5	salts	salt	NOUN
admet-2802	440	6	and	and	CCONJ
admet-2802	440	7	mixed	mixed	ADJ
admet-2802	440	8	micelles	micelle	NOUN
admet-2802	440	9	on	on	ADP
admet-2802	440	10	the	the	DET
admet-2802	440	11	pharmacokinetics	pharmacokinetic	NOUN
admet-2802	440	12	of	of	ADP
admet-2802	440	13	quinine	quinine	NOUN
admet-2802	440	14	in	in	ADP
admet-2802	440	15	rabbits	rabbit	NOUN
admet-2802	440	16	.	.	PUNCT
admet-2802	441	1	european	european	PROPN
admet-2802	441	2	journal	journal	PROPN
admet-2802	441	3	of	of	ADP
admet-2802	441	4	pharmaceutics	pharmaceutic	NOUN
admet-2802	441	5	and	and	CCONJ
admet-2802	441	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2802	441	7	60	60	NUM
admet-2802	441	8	(	(	PUNCT
admet-2802	441	9	2005	2005	NUM
admet-2802	441	10	)	)	PUNCT
admet-2802	441	11	147	147	NUM
admet-2802	441	12	-	-	SYM
admet-2802	441	13	151	151	NUM
admet-2802	441	14	.	.	PUNCT
admet-2802	442	1	https://doi.org/10.1016/j.ejpb.2005.01.003	https://doi.org/10.1016/j.ejpb.2005.01.003	PROPN
admet-2802	442	2	[	[	X
admet-2802	442	3	33	33	NUM
admet-2802	442	4	]	]	X
admet-2802	442	5	f.l	f.l	PROPN
admet-2802	442	6	.	.	PROPN
admet-2802	442	7	holzem	holzem	PROPN
admet-2802	442	8	,	,	PUNCT
admet-2802	442	9	r.l	r.l	PROPN
admet-2802	442	10	.	.	PROPN
admet-2802	442	11	mikkelsen	mikkelsen	PROPN
admet-2802	442	12	,	,	PUNCT
admet-2802	442	13	j.p	j.p	PROPN
admet-2802	442	14	.	.	PROPN
admet-2802	442	15	schaffland	schaffland	PROPN
admet-2802	442	16	,	,	PUNCT
admet-2802	442	17	c.	c.	PROPN
admet-2802	442	18	stillhart	stillhart	PROPN
admet-2802	442	19	,	,	PUNCT
admet-2802	442	20	m.	m.	PROPN
admet-2802	442	21	brandl	brandl	PROPN
admet-2802	442	22	,	,	PUNCT
admet-2802	442	23	a.	a.	PROPN
admet-2802	442	24	bauer	bauer	PROPN
admet-2802	442	25	-	-	PUNCT
admet-2802	442	26	brandl	brandl	PROPN
admet-2802	442	27	.	.	PUNCT
admet-2802	443	1	a	a	DET
admet-2802	443	2	highthroughput	highthroughput	ADJ
admet-2802	443	3	micro	micro	ADJ
admet-2802	443	4	-	-	NOUN
admet-2802	443	5	scale	scale	ADJ
admet-2802	443	6	workflow	workflow	NOUN
admet-2802	443	7	to	to	PART
admet-2802	443	8	quantify	quantify	VERB
admet-2802	443	9	molecularly	molecularly	ADV
admet-2802	443	10	dissolved	dissolve	VERB
admet-2802	443	11	drug	drug	NOUN
admet-2802	443	12	concentrations	concentration	NOUN
admet-2802	443	13	under	under	ADP
admet-2802	443	14	solubilizing	solubilize	VERB
admet-2802	443	15	conditions	condition	NOUN
admet-2802	443	16	.	.	PUNCT
admet-2802	444	1	journal	journal	NOUN
admet-2802	444	2	of	of	ADP
admet-2802	444	3	pharmaceutical	pharmaceutical	PROPN
admet-2802	444	4	sciences	science	NOUN
admet-2802	444	5	114	114	NUM
admet-2802	444	6	(	(	PUNCT
admet-2802	444	7	2025	2025	NUM
admet-2802	444	8	)	)	PUNCT
admet-2802	444	9	1485	1485	NUM
admet-2802	444	10	-	-	SYM
admet-2802	444	11	1494	1494	NUM
admet-2802	444	12	.	.	PUNCT
admet-2802	445	1	https://doi.org/10.1016/j.xphs.2024.12.027	https://doi.org/10.1016/j.xphs.2024.12.027	ADJ
admet-2802	445	2	©	©	ADP
admet-2802	445	3	2025	2025	NUM
admet-2802	445	4	by	by	ADP
admet-2802	445	5	the	the	DET
admet-2802	445	6	authors	author	NOUN
admet-2802	445	7	;	;	PUNCT
admet-2802	445	8	licensee	licensee	PROPN
admet-2802	445	9	iapc	iapc	PROPN
admet-2802	445	10	,	,	PUNCT
admet-2802	445	11	zagreb	zagreb	PROPN
admet-2802	445	12	,	,	PUNCT
admet-2802	445	13	croatia	croatia	PROPN
admet-2802	445	14	.	.	PUNCT
admet-2802	446	1	this	this	DET
admet-2802	446	2	article	article	NOUN
admet-2802	446	3	is	be	AUX
admet-2802	446	4	an	an	DET
admet-2802	446	5	open	open	ADJ
admet-2802	446	6	-	-	PUNCT
admet-2802	446	7	access	access	NOUN
admet-2802	446	8	article	article	NOUN
admet-2802	446	9	distributed	distribute	VERB
admet-2802	446	10	under	under	ADP
admet-2802	446	11	the	the	DET
admet-2802	446	12	terms	term	NOUN
admet-2802	446	13	and	and	CCONJ
admet-2802	446	14	conditions	condition	NOUN
admet-2802	446	15	of	of	ADP
admet-2802	446	16	the	the	DET
admet-2802	446	17	creative	creative	ADJ
admet-2802	446	18	commons	common	NOUN
admet-2802	446	19	attribution	attribution	NOUN
admet-2802	446	20	license	license	NOUN
admet-2802	446	21	(	(	PUNCT
admet-2802	446	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2802	446	23	)	)	PUNCT
admet-2802	446	24	https://doi.org/10.1016/j.ejpb.2005.01.003	https://doi.org/10.1016/j.ejpb.2005.01.003	PROPN
admet-2802	447	1	https://doi.org/10.1016/j.xphs.2024.12.027	https://doi.org/10.1016/j.xphs.2024.12.027	ADJ
admet-2802	447	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN