id	sid	tid	token	lemma	pos
admet-286	1	1	doi	doi	NOUN
admet-286	1	2	:	:	PUNCT
admet-286	1	3	10.5599	10.5599	NUM
admet-286	1	4	/	/	SYM
admet-286	1	5	admet.4.3.286	admet.4.3.286	ADJ
admet-286	1	6	241	241	NUM
admet-286	1	7	admet	admet	PROPN
admet-286	1	8	&	&	CCONJ
admet-286	1	9	dmpk	dmpk	PROPN
admet-286	1	10	4(3	4(3	NUM
admet-286	1	11	)	)	PUNCT
admet-286	1	12	(	(	PUNCT
admet-286	1	13	2016	2016	NUM
admet-286	1	14	)	)	PUNCT
admet-286	1	15	241	241	NUM
admet-286	1	16	-	-	SYM
admet-286	1	17	260	260	NUM
admet-286	1	18	;	;	PUNCT
admet-286	1	19	doi	doi	NOUN
admet-286	1	20	:	:	PUNCT
admet-286	1	21	10.5599	10.5599	NUM
admet-286	1	22	/	/	SYM
admet-286	1	23	admet.4.3.286	admet.4.3.286	VERB
admet-286	1	24	open	open	ADJ
admet-286	1	25	access	access	NOUN
admet-286	1	26	:	:	PUNCT
admet-286	1	27	issn	issn	PROPN
admet-286	1	28	:	:	PUNCT
admet-286	1	29	1848	1848	NUM
admet-286	1	30	-	-	SYM
admet-286	1	31	7718	7718	NUM
admet-286	1	32	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-286	1	33	original	original	ADJ
admet-286	1	34	scientific	scientific	ADJ
admet-286	1	35	paper	paper	NOUN
admet-286	1	36	dose	dose	NOUN
admet-286	1	37	optimization	optimization	NOUN
admet-286	1	38	of	of	ADP
admet-286	1	39	ceftriaxone	ceftriaxone	PROPN
admet-286	1	40	-	-	PUNCT
admet-286	1	41	vancomycin	vancomycin	PROPN
admet-286	1	42	combination	combination	NOUN
admet-286	1	43	using	use	VERB
admet-286	1	44	fractional	fractional	ADJ
admet-286	1	45	inhibitory	inhibitory	ADJ
admet-286	1	46	concentration	concentration	NOUN
admet-286	1	47	kinetics	kinetic	NOUN
admet-286	1	48	in	in	ADP
admet-286	1	49	resistant	resistant	ADJ
admet-286	1	50	bacteria	bacteria	NOUN
admet-286	1	51	vishnu	vishnu	PROPN
admet-286	1	52	d	d	PROPN
admet-286	1	53	sharma	sharma	PROPN
admet-286	1	54	*	*	PROPN
admet-286	1	55	,	,	PUNCT
admet-286	1	56	aman	aman	VERB
admet-286	1	57	singla	singla	PROPN
admet-286	1	58	,	,	PUNCT
admet-286	1	59	manu	manu	PROPN
admet-286	1	60	chaudhary	chaudhary	PROPN
admet-286	1	61	,	,	PUNCT
admet-286	1	62	mukesh	mukesh	PROPN
admet-286	1	63	kumar	kumar	PROPN
admet-286	1	64	,	,	PUNCT
admet-286	1	65	anuj	anuj	PROPN
admet-286	1	66	bhatnagar	bhatnagar	PROPN
admet-286	1	67	,	,	PUNCT
admet-286	1	68	shailesh	shailesh	PROPN
admet-286	1	69	kumar	kumar	PROPN
admet-286	1	70	,	,	PUNCT
admet-286	1	71	manish	manish	PROPN
admet-286	1	72	taneja	taneja	PROPN
admet-286	1	73	*	*	PROPN
admet-286	1	74	venus	venus	PROPN
admet-286	1	75	medicine	medicine	NOUN
admet-286	1	76	research	research	NOUN
admet-286	1	77	centre	centre	PROPN
admet-286	1	78	,	,	PUNCT
admet-286	1	79	hill	hill	NOUN
admet-286	1	80	top	top	ADJ
admet-286	1	81	estate	estate	NOUN
admet-286	1	82	,	,	PUNCT
admet-286	1	83	bhatoli	bhatoli	VERB
admet-286	1	84	kalan	kalan	PROPN
admet-286	1	85	,	,	PUNCT
admet-286	1	86	h.p	h.p	PROPN
admet-286	1	87	.	.	PROPN
admet-286	1	88	,	,	PUNCT
admet-286	1	89	india	india	PROPN
admet-286	1	90	*	*	PUNCT
admet-286	1	91	corresponding	correspond	VERB
admet-286	1	92	authors	author	NOUN
admet-286	1	93	.	.	PUNCT
admet-286	2	1	e	e	X
admet-286	2	2	-	-	NOUN
admet-286	2	3	mail	mail	NOUN
admet-286	2	4	:	:	PUNCT
admet-286	2	5	vishnudutt070788@gmail.com	vishnudutt070788@gmail.com	PROPN
admet-286	2	6	&	&	CCONJ
admet-286	2	7	manishtaneja24@gmail.com	manishtaneja24@gmail.com	PROPN
admet-286	2	8	;	;	PUNCT
admet-286	2	9	tel	tel	PROPN
admet-286	2	10	.	.	PUNCT
admet-286	2	11	:	:	PUNCT
admet-286	3	1	+91	+91	PROPN
admet-286	3	2	-	-	SYM
admet-286	3	3	9871681044	9871681044	NUM
admet-286	3	4	received	receive	VERB
admet-286	3	5	:	:	PUNCT
admet-286	3	6	may	may	AUX
admet-286	3	7	02	02	NUM
admet-286	3	8	,	,	PUNCT
admet-286	3	9	2016	2016	NUM
admet-286	3	10	;	;	PUNCT
admet-286	3	11	revised	revise	VERB
admet-286	3	12	:	:	PUNCT
admet-286	3	13	july	july	PROPN
admet-286	3	14	12	12	NUM
admet-286	3	15	,	,	PUNCT
admet-286	3	16	2016	2016	NUM
admet-286	3	17	;	;	PUNCT
admet-286	3	18	published	publish	VERB
admet-286	3	19	:	:	PUNCT
admet-286	3	20	september	september	PROPN
admet-286	3	21	30	30	NUM
admet-286	3	22	,	,	PUNCT
admet-286	3	23	2016	2016	NUM
admet-286	3	24	abstract	abstract	NOUN
admet-286	3	25	the	the	DET
admet-286	3	26	notorious	notorious	ADJ
admet-286	3	27	staphylococcus	staphylococcus	NOUN
admet-286	3	28	aureus	aureus	NOUN
admet-286	3	29	resistant	resistant	ADJ
admet-286	3	30	strains	strain	NOUN
admet-286	3	31	with	with	ADP
admet-286	3	32	ever	ever	ADV
admet-286	3	33	changing	change	VERB
admet-286	3	34	resistance	resistance	NOUN
admet-286	3	35	patterns	pattern	NOUN
admet-286	3	36	have	have	VERB
admet-286	3	37	limited	limit	VERB
admet-286	3	38	treatment	treatment	NOUN
admet-286	3	39	options	option	NOUN
admet-286	3	40	and	and	CCONJ
admet-286	3	41	have	have	AUX
admet-286	3	42	led	lead	VERB
admet-286	3	43	to	to	ADP
admet-286	3	44	substantial	substantial	ADJ
admet-286	3	45	number	number	NOUN
admet-286	3	46	of	of	ADP
admet-286	3	47	deaths	death	NOUN
admet-286	3	48	.	.	PUNCT
admet-286	4	1	almost	almost	ADV
admet-286	4	2	dried	dry	VERB
admet-286	4	3	antibiotic	antibiotic	ADJ
admet-286	4	4	pipeline	pipeline	NOUN
admet-286	4	5	has	have	AUX
admet-286	4	6	led	lead	VERB
admet-286	4	7	us	we	PRON
admet-286	4	8	to	to	PART
admet-286	4	9	look	look	VERB
admet-286	4	10	into	into	ADP
admet-286	4	11	combinations	combination	NOUN
admet-286	4	12	of	of	ADP
admet-286	4	13	already	already	ADV
admet-286	4	14	approved	approve	VERB
admet-286	4	15	antibiotics	antibiotic	NOUN
admet-286	4	16	for	for	ADP
admet-286	4	17	tackling	tackle	VERB
admet-286	4	18	rising	rise	VERB
admet-286	4	19	incidence	incidence	NOUN
admet-286	4	20	of	of	ADP
admet-286	4	21	antibacterial	antibacterial	ADJ
admet-286	4	22	resistance	resistance	NOUN
admet-286	4	23	.	.	PUNCT
admet-286	5	1	recommended	recommend	VERB
admet-286	5	2	use	use	NOUN
admet-286	5	3	of	of	ADP
admet-286	5	4	vancomycin	vancomycin	PROPN
admet-286	5	5	and	and	CCONJ
admet-286	5	6	ceftriaxone	ceftriaxone	PROPN
admet-286	5	7	together	together	ADV
admet-286	5	8	for	for	ADP
admet-286	5	9	treating	treat	VERB
admet-286	5	10	severe	severe	ADJ
admet-286	5	11	infections	infection	NOUN
admet-286	5	12	involving	involve	VERB
admet-286	5	13	resistant	resistant	ADJ
admet-286	5	14	s.	s.	PROPN
admet-286	5	15	aureus	aureus	PROPN
admet-286	5	16	is	be	AUX
admet-286	5	17	limited	limit	VERB
admet-286	5	18	by	by	ADP
admet-286	5	19	dose	dose	NOUN
admet-286	5	20	adjustments	adjustment	NOUN
admet-286	5	21	and	and	CCONJ
admet-286	5	22	different	different	ADJ
admet-286	5	23	dose	dose	NOUN
admet-286	5	24	frequencies	frequency	NOUN
admet-286	5	25	.	.	PUNCT
admet-286	6	1	we	we	PRON
admet-286	6	2	have	have	AUX
admet-286	6	3	developed	develop	VERB
admet-286	6	4	a	a	DET
admet-286	6	5	pharmacodynamically	pharmacodynamically	ADV
admet-286	6	6	synergistic	synergistic	ADJ
admet-286	6	7	fixed	fix	VERB
admet-286	6	8	dose	dose	NOUN
admet-286	6	9	combination	combination	NOUN
admet-286	6	10	(	(	PUNCT
admet-286	6	11	fdc	fdc	PROPN
admet-286	6	12	)	)	PUNCT
admet-286	6	13	of	of	ADP
admet-286	6	14	ceftriaxone	ceftriaxone	NOUN
admet-286	6	15	and	and	CCONJ
admet-286	6	16	vancomycin	vancomycin	PROPN
admet-286	6	17	(	(	PUNCT
admet-286	6	18	2:1	2:1	NUM
admet-286	6	19	)	)	PUNCT
admet-286	6	20	,	,	PUNCT
admet-286	6	21	for	for	ADP
admet-286	6	22	eliminating	eliminate	VERB
admet-286	6	23	individual	individual	ADJ
admet-286	6	24	component	component	NOUN
admet-286	6	25	dose	dose	NOUN
admet-286	6	26	adjustments	adjustment	NOUN
admet-286	6	27	and	and	CCONJ
admet-286	6	28	frequencies	frequency	NOUN
admet-286	6	29	.	.	PUNCT
admet-286	7	1	for	for	ADP
admet-286	7	2	identification	identification	NOUN
admet-286	7	3	of	of	ADP
admet-286	7	4	optimum	optimum	ADJ
admet-286	7	5	exposureresponse	exposureresponse	NOUN
admet-286	7	6	of	of	ADP
admet-286	7	7	fdc	fdc	PROPN
admet-286	7	8	,	,	PUNCT
admet-286	7	9	one	one	NUM
admet-286	7	10	compartment	compartment	NOUN
admet-286	7	11	in	in	ADP
admet-286	7	12	vitro	vitro	X
admet-286	7	13	system	system	NOUN
admet-286	7	14	was	be	AUX
admet-286	7	15	used	use	VERB
admet-286	7	16	for	for	ADP
admet-286	7	17	dose	dose	NOUN
admet-286	7	18	escalation	escalation	NOUN
admet-286	7	19	,	,	PUNCT
admet-286	7	20	fractionation	fractionation	NOUN
admet-286	7	21	and	and	CCONJ
admet-286	7	22	doseresponse	doseresponse	NOUN
admet-286	7	23	studies	study	NOUN
admet-286	7	24	.	.	PUNCT
admet-286	8	1	the	the	DET
admet-286	8	2	in	in	ADP
admet-286	8	3	-	-	PUNCT
admet-286	8	4	silico	silico	NOUN
admet-286	8	5	pharmacokinetic	pharmacokinetic	NOUN
admet-286	8	6	/	/	SYM
admet-286	8	7	pharmacodynamic	pharmacodynamic	ADJ
admet-286	8	8	(	(	PUNCT
admet-286	8	9	pk	pk	NOUN
admet-286	8	10	/	/	SYM
admet-286	8	11	pd	pd	NOUN
admet-286	8	12	)	)	PUNCT
admet-286	8	13	modeling	modeling	NOUN
admet-286	8	14	,	,	PUNCT
admet-286	8	15	simulations	simulation	NOUN
admet-286	8	16	and	and	CCONJ
admet-286	8	17	validations	validation	NOUN
admet-286	8	18	were	be	AUX
admet-286	8	19	done	do	VERB
admet-286	8	20	.	.	PUNCT
admet-286	9	1	the	the	DET
admet-286	9	2	results	result	NOUN
admet-286	9	3	suggested	suggest	VERB
admet-286	9	4	%	%	PROPN
admet-286	9	5	t	t	PROPN
admet-286	9	6	>	>	X
admet-286	9	7	miccomb	miccomb	PROPN
admet-286	9	8	(	(	PUNCT
admet-286	9	9	percentage	percentage	NOUN
admet-286	9	10	of	of	ADP
admet-286	9	11	time	time	NOUN
admet-286	9	12	fractional	fractional	ADJ
admet-286	9	13	inhibitory	inhibitory	ADJ
admet-286	9	14	concentrations	concentration	NOUN
admet-286	9	15	of	of	ADP
admet-286	9	16	the	the	DET
admet-286	9	17	drugs	drug	NOUN
admet-286	9	18	combined	combine	VERB
admet-286	9	19	remained	remain	VERB
admet-286	9	20	above	above	ADP
admet-286	9	21	the	the	DET
admet-286	9	22	miccomb	miccomb	NOUN
admet-286	10	1	[	[	X
admet-286	10	2	minimum	minimum	ADJ
admet-286	10	3	inhibitory	inhibitory	ADJ
admet-286	10	4	concentration	concentration	NOUN
admet-286	10	5	for	for	ADP
admet-286	10	6	fdc	fdc	PROPN
admet-286	10	7	]	]	PUNCT
admet-286	10	8	)	)	PUNCT
admet-286	10	9	followed	follow	VERB
admet-286	10	10	by	by	ADP
admet-286	10	11	auccomb	auccomb	NOUN
admet-286	10	12	/	/	SYM
admet-286	10	13	miccomb	miccomb	PROPN
admet-286	10	14	(	(	PUNCT
admet-286	10	15	ratio	ratio	NOUN
admet-286	10	16	of	of	ADP
admet-286	10	17	area	area	NOUN
admet-286	10	18	under	under	ADP
admet-286	10	19	fractional	fractional	ADJ
admet-286	10	20	inhibitory	inhibitory	ADJ
admet-286	10	21	curves	curve	NOUN
admet-286	10	22	to	to	PART
admet-286	10	23	miccomb	miccomb	VERB
admet-286	10	24	)	)	PUNCT
admet-286	10	25	can	can	AUX
admet-286	10	26	predict	predict	VERB
admet-286	10	27	the	the	DET
admet-286	10	28	exposure	exposure	NOUN
admet-286	10	29	(	(	PUNCT
admet-286	10	30	dose	dose	NOUN
admet-286	10	31	of	of	ADP
admet-286	10	32	fdc)-response	fdc)-response	PROPN
admet-286	10	33	(	(	PUNCT
admet-286	10	34	reduction	reduction	NOUN
admet-286	10	35	in	in	ADP
admet-286	10	36	bacterial	bacterial	ADJ
admet-286	10	37	load	load	NOUN
admet-286	10	38	)	)	PUNCT
admet-286	10	39	relationships	relationship	NOUN
admet-286	10	40	effectively	effectively	ADV
admet-286	10	41	(	(	PUNCT
admet-286	10	42	r2	r2	PROPN
admet-286	10	43	>	>	X
admet-286	10	44	0.9	0.9	NUM
admet-286	10	45	)	)	PUNCT
admet-286	10	46	.	.	PUNCT
admet-286	11	1	total	total	ADJ
admet-286	11	2	exposure	exposure	NOUN
admet-286	11	3	of	of	ADP
admet-286	11	4	6	6	NUM
admet-286	11	5	g	g	NOUN
admet-286	11	6	in	in	ADP
admet-286	11	7	two	two	NUM
admet-286	11	8	divided	divide	VERB
admet-286	11	9	doses	dose	NOUN
admet-286	11	10	(	(	PUNCT
admet-286	11	11	3	3	NUM
admet-286	11	12	g	g	NOUN
admet-286	11	13	each	each	PRON
admet-286	11	14	)	)	PUNCT
admet-286	11	15	was	be	AUX
admet-286	11	16	identified	identify	VERB
admet-286	11	17	to	to	PART
admet-286	11	18	be	be	AUX
admet-286	11	19	optimum	optimum	ADJ
admet-286	11	20	.	.	PUNCT
admet-286	12	1	monte	monte	PROPN
admet-286	12	2	carlo	carlo	PROPN
admet-286	12	3	simulations	simulation	NOUN
admet-286	12	4	were	be	AUX
admet-286	12	5	performed	perform	VERB
admet-286	12	6	to	to	PART
admet-286	12	7	evaluate	evaluate	VERB
admet-286	12	8	the	the	DET
admet-286	12	9	effect	effect	NOUN
admet-286	12	10	of	of	ADP
admet-286	12	11	increasing	increase	VERB
admet-286	12	12	doses	dose	NOUN
admet-286	12	13	against	against	ADP
admet-286	12	14	different	different	ADJ
admet-286	12	15	mics	mic	NOUN
admet-286	12	16	.	.	PUNCT
admet-286	13	1	clinical	clinical	ADJ
admet-286	13	2	breakpoint	breakpoint	NOUN
admet-286	13	3	of	of	ADP
admet-286	13	4	the	the	DET
admet-286	13	5	fdc	fdc	PROPN
admet-286	13	6	was	be	AUX
admet-286	13	7	identified	identify	VERB
admet-286	13	8	to	to	PART
admet-286	13	9	be	be	AUX
admet-286	13	10	4	4	NUM
admet-286	13	11	µg	µg	ADV
admet-286	13	12	/	/	SYM
admet-286	13	13	ml	ml	NOUN
admet-286	13	14	,	,	PUNCT
admet-286	13	15	which	which	PRON
admet-286	13	16	was	be	AUX
admet-286	13	17	2	2	NUM
admet-286	13	18	fold	fold	NOUN
admet-286	13	19	higher	high	ADJ
admet-286	13	20	than	than	ADP
admet-286	13	21	that	that	PRON
admet-286	13	22	of	of	ADP
admet-286	13	23	vancomycin	vancomycin	PROPN
admet-286	13	24	suggesting	suggest	VERB
admet-286	13	25	better	well	ADJ
admet-286	13	26	antibacterial	antibacterial	ADJ
admet-286	13	27	coverage	coverage	NOUN
admet-286	13	28	.	.	PUNCT
admet-286	14	1	keywords	keyword	NOUN
admet-286	14	2	pk	pk	PROPN
admet-286	14	3	/	/	SYM
admet-286	14	4	pd	pd	NOUN
admet-286	14	5	modelling	modelling	NOUN
admet-286	14	6	;	;	PUNCT
admet-286	14	7	fixed	fix	VERB
admet-286	14	8	dose	dose	NOUN
admet-286	14	9	combination	combination	NOUN
admet-286	14	10	;	;	PUNCT
admet-286	14	11	monte	monte	PROPN
admet-286	14	12	carlo	carlo	PROPN
admet-286	14	13	simulations	simulation	NOUN
admet-286	14	14	;	;	PUNCT
admet-286	14	15	antibacterial	antibacterial	ADJ
admet-286	14	16	resistance	resistance	NOUN
admet-286	14	17	introduction	introduction	NOUN
admet-286	14	18	the	the	DET
admet-286	14	19	bacteria	bacteria	NOUN
admet-286	14	20	methicillin	methicillin	NOUN
admet-286	14	21	-	-	PUNCT
admet-286	14	22	resistant	resistant	ADJ
admet-286	14	23	staphylococcus	staphylococcus	NOUN
admet-286	14	24	aureus	aureus	NOUN
admet-286	14	25	(	(	PUNCT
admet-286	14	26	mrsa	mrsa	NOUN
admet-286	14	27	)	)	PUNCT
admet-286	14	28	is	be	AUX
admet-286	14	29	one	one	NUM
admet-286	14	30	of	of	ADP
admet-286	14	31	most	most	ADJ
admet-286	14	32	common	common	ADJ
admet-286	14	33	pathogen	pathogen	NOUN
admet-286	14	34	responsible	responsible	ADJ
admet-286	14	35	for	for	ADP
admet-286	14	36	nosocomial	nosocomial	ADJ
admet-286	14	37	infections	infection	NOUN
admet-286	14	38	.	.	PUNCT
admet-286	15	1	it	it	PRON
admet-286	15	2	is	be	AUX
admet-286	15	3	associated	associate	VERB
admet-286	15	4	with	with	ADP
admet-286	15	5	an	an	DET
admet-286	15	6	increased	increase	VERB
admet-286	15	7	risk	risk	NOUN
admet-286	15	8	of	of	ADP
admet-286	15	9	mortality	mortality	NOUN
admet-286	15	10	and	and	CCONJ
admet-286	15	11	morbidity	morbidity	NOUN
admet-286	15	12	,	,	PUNCT
admet-286	15	13	requiring	require	VERB
admet-286	15	14	prolonged	prolonged	ADJ
admet-286	15	15	duration	duration	NOUN
admet-286	15	16	of	of	ADP
admet-286	15	17	treatment	treatment	NOUN
admet-286	15	18	and	and	CCONJ
admet-286	15	19	increased	increase	VERB
admet-286	15	20	cost	cost	NOUN
admet-286	15	21	[	[	X
admet-286	15	22	1	1	NUM
admet-286	15	23	]	]	PUNCT
admet-286	15	24	.	.	PUNCT
admet-286	16	1	it	it	PRON
admet-286	16	2	is	be	AUX
admet-286	16	3	reported	report	VERB
admet-286	16	4	that	that	SCONJ
admet-286	16	5	out	out	ADP
admet-286	16	6	of	of	ADP
admet-286	16	7	10,800	10,800	NUM
admet-286	16	8	deaths	death	NOUN
admet-286	16	9	per	per	ADP
admet-286	16	10	year	year	NOUN
admet-286	16	11	by	by	ADP
admet-286	16	12	infections	infection	NOUN
admet-286	16	13	in	in	ADP
admet-286	16	14	united	united	PROPN
admet-286	16	15	states	states	PROPN
admet-286	16	16	,	,	PUNCT
admet-286	16	17	5,500	5,500	NUM
admet-286	16	18	deaths	death	NOUN
admet-286	16	19	are	be	AUX
admet-286	16	20	linked	link	VERB
admet-286	16	21	to	to	ADP
admet-286	16	22	mrsa	mrsa	NOUN
admet-286	16	23	.	.	PUNCT
admet-286	17	1	the	the	DET
admet-286	17	2	prevalence	prevalence	NOUN
admet-286	17	3	of	of	ADP
admet-286	17	4	mrsa	mrsa	NOUN
admet-286	17	5	is	be	AUX
admet-286	17	6	extrapolated	extrapolate	VERB
admet-286	17	7	to	to	ADP
admet-286	17	8	1	1	NUM
admet-286	17	9	billion	billion	NUM
admet-286	17	10	people	people	NOUN
admet-286	17	11	by	by	ADP
admet-286	17	12	year	year	NOUN
admet-286	17	13	2022	2022	NUM
admet-286	18	1	[	[	X
admet-286	18	2	1	1	NUM
admet-286	18	3	]	]	PUNCT
admet-286	18	4	.	.	PUNCT
admet-286	19	1	vancomycin	vancomycin	PROPN
admet-286	19	2	is	be	AUX
admet-286	19	3	the	the	DET
admet-286	19	4	empirical	empirical	ADJ
admet-286	19	5	choice	choice	NOUN
admet-286	19	6	for	for	ADP
admet-286	19	7	treating	treat	VERB
admet-286	19	8	these	these	DET
admet-286	19	9	infections	infection	NOUN
admet-286	19	10	.	.	PUNCT
admet-286	20	1	however	however	ADV
admet-286	20	2	,	,	PUNCT
admet-286	20	3	extensive	extensive	ADJ
admet-286	20	4	vancomycin	vancomycin	NOUN
admet-286	20	5	use	use	NOUN
admet-286	20	6	has	have	AUX
admet-286	20	7	led	lead	VERB
admet-286	20	8	to	to	PART
admet-286	20	9	emergence	emergence	VERB
admet-286	20	10	of	of	ADP
admet-286	20	11	mrsa	mrsa	NOUN
admet-286	20	12	with	with	ADP
admet-286	20	13	reduced	reduce	VERB
admet-286	20	14	vancomycin	vancomycin	PROPN
admet-286	20	15	susceptibility	susceptibility	NOUN
admet-286	20	16	.	.	PUNCT
admet-286	21	1	in	in	ADP
admet-286	21	2	2006	2006	NUM
admet-286	21	3	,	,	PUNCT
admet-286	21	4	the	the	DET
admet-286	21	5	minimum	minimum	ADJ
admet-286	21	6	inhibitory	inhibitory	ADJ
admet-286	21	7	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-286	21	8	mailto:vishnudutt070788@gmail.com	mailto:vishnudutt070788@gmail.com	PROPN
admet-286	21	9	mailto:manishtaneja24@gmail.com	mailto:manishtaneja24@gmail.com	PROPN
admet-286	21	10	vishnu	vishnu	PROPN
admet-286	21	11	sharma	sharma	PROPN
admet-286	21	12	et	et	PROPN
admet-286	21	13	al	al	PROPN
admet-286	21	14	.	.	PROPN
admet-286	21	15	admet	admet	PROPN
admet-286	21	16	&	&	CCONJ
admet-286	21	17	dmpk	dmpk	PROPN
admet-286	21	18	4(3	4(3	NUM
admet-286	21	19	)	)	PUNCT
admet-286	21	20	(	(	PUNCT
admet-286	21	21	2016	2016	NUM
admet-286	21	22	)	)	PUNCT
admet-286	21	23	241	241	NUM
admet-286	21	24	-	-	SYM
admet-286	21	25	260	260	NUM
admet-286	21	26	242	242	NUM
admet-286	21	27	concentration	concentration	NOUN
admet-286	21	28	(	(	PUNCT
admet-286	21	29	mic	mic	ADJ
admet-286	21	30	)	)	PUNCT
admet-286	21	31	breakpoints	breakpoint	NOUN
admet-286	21	32	for	for	ADP
admet-286	21	33	s.	s.	PROPN
admet-286	21	34	aureus	aureus	PROPN
admet-286	21	35	were	be	AUX
admet-286	21	36	lowered	lower	VERB
admet-286	21	37	(	(	PUNCT
admet-286	21	38	from	from	ADP
admet-286	21	39	≤4	≤4	NOUN
admet-286	21	40	µg	µg	NOUN
admet-286	21	41	/	/	SYM
admet-286	21	42	ml	ml	NOUN
admet-286	21	43	to	to	PART
admet-286	21	44	≤2	≤2	VERB
admet-286	21	45	µg	µg	VERB
admet-286	21	46	/	/	SYM
admet-286	21	47	ml	ml	X
admet-286	21	48	for	for	ADP
admet-286	21	49	“	"	PUNCT
admet-286	21	50	susceptible	susceptible	ADJ
admet-286	21	51	,	,	PUNCT
admet-286	21	52	”	"	PUNCT
admet-286	21	53	from	from	ADP
admet-286	21	54	8–16	8–16	PROPN
admet-286	21	55	µg	µg	ADV
admet-286	21	56	/	/	SYM
admet-286	21	57	ml	ml	NOUN
admet-286	21	58	to	to	ADP
admet-286	21	59	4–8	4–8	NUM
admet-286	21	60	µg	µg	VERB
admet-286	21	61	/	/	SYM
admet-286	21	62	ml	ml	X
admet-286	21	63	for	for	ADP
admet-286	21	64	“	"	PUNCT
admet-286	21	65	intermediate	intermediate	ADJ
admet-286	21	66	,	,	PUNCT
admet-286	21	67	”	"	PUNCT
admet-286	21	68	and	and	CCONJ
admet-286	21	69	from	from	ADP
admet-286	21	70	≥32	≥32	PROPN
admet-286	21	71	µg	µg	ADV
admet-286	21	72	/	/	SYM
admet-286	21	73	ml	ml	NOUN
admet-286	21	74	to	to	ADP
admet-286	21	75	≥	≥	NOUN
admet-286	21	76	16	16	NUM
admet-286	21	77	µg	µg	NOUN
admet-286	21	78	/	/	SYM
admet-286	21	79	ml	ml	X
admet-286	21	80	for	for	ADP
admet-286	21	81	“	"	PUNCT
admet-286	21	82	resistant	resistant	ADJ
admet-286	21	83	”	"	PUNCT
admet-286	21	84	)	)	PUNCT
admet-286	21	85	and	and	CCONJ
admet-286	21	86	vancomycin	vancomycin	PROPN
admet-286	21	87	was	be	AUX
admet-286	21	88	less	less	ADV
admet-286	21	89	likely	likely	ADJ
admet-286	21	90	to	to	PART
admet-286	21	91	respond	respond	VERB
admet-286	21	92	when	when	SCONJ
admet-286	21	93	mics	mic	NOUN
admet-286	21	94	were	be	AUX
admet-286	21	95	≥4µg	≥4µg	NOUN
admet-286	21	96	/	/	SYM
admet-286	21	97	ml	ml	X
admet-286	22	1	[	[	X
admet-286	22	2	2	2	NUM
admet-286	22	3	]	]	PUNCT
admet-286	22	4	.	.	PUNCT
admet-286	23	1	the	the	DET
admet-286	23	2	clinical	clinical	ADJ
admet-286	23	3	relevance	relevance	NOUN
admet-286	23	4	of	of	ADP
admet-286	23	5	change	change	NOUN
admet-286	23	6	in	in	ADP
admet-286	23	7	breakpoint	breakpoint	NOUN
admet-286	23	8	was	be	AUX
admet-286	23	9	further	far	ADV
admet-286	23	10	highlighted	highlight	VERB
admet-286	23	11	by	by	ADP
admet-286	23	12	the	the	DET
admet-286	23	13	observation	observation	NOUN
admet-286	23	14	wherein	wherein	ADJ
admet-286	23	15	subjects	subject	NOUN
admet-286	23	16	with	with	ADP
admet-286	23	17	high	high	ADJ
admet-286	23	18	grade	grade	NOUN
admet-286	23	19	infections	infection	NOUN
admet-286	23	20	required	require	VERB
admet-286	23	21	high	high	ADJ
admet-286	23	22	vancomycin	vancomycin	PROPN
admet-286	23	23	mics	mic	NOUN
admet-286	23	24	leading	lead	VERB
admet-286	23	25	to	to	ADP
admet-286	23	26	therapy	therapy	NOUN
admet-286	23	27	failures	failure	NOUN
admet-286	23	28	or	or	CCONJ
admet-286	23	29	increase	increase	VERB
admet-286	23	30	in	in	ADP
admet-286	23	31	mortality	mortality	NOUN
admet-286	23	32	.	.	PUNCT
admet-286	24	1	mechanistically	mechanistically	ADV
admet-286	24	2	,	,	PUNCT
admet-286	24	3	vancomycin	vancomycin	PROPN
admet-286	24	4	binds	bind	VERB
admet-286	24	5	to	to	ADP
admet-286	24	6	the	the	DET
admet-286	24	7	terminal	terminal	ADJ
admet-286	24	8	d	d	X
admet-286	24	9	-	-	PUNCT
admet-286	24	10	alanyl	alanyl	VERB
admet-286	24	11	-	-	PUNCT
admet-286	24	12	d	d	NOUN
admet-286	24	13	-	-	PUNCT
admet-286	24	14	alanine	alanine	NOUN
admet-286	24	15	moieties	moiety	NOUN
admet-286	24	16	of	of	ADP
admet-286	24	17	the	the	DET
admet-286	24	18	n	n	CCONJ
admet-286	24	19	-	-	PUNCT
admet-286	24	20	acetyl	acetyl	NOUN
admet-286	24	21	muramic	muramic	ADJ
admet-286	24	22	acid	acid	NOUN
admet-286	24	23	/	/	SYM
admet-286	24	24	n	n	CCONJ
admet-286	24	25	-	-	PUNCT
admet-286	24	26	acetyl	acetyl	NOUN
admet-286	24	27	glucosaminepeptides	glucosaminepeptide	NOUN
admet-286	24	28	,	,	PUNCT
admet-286	24	29	subsequently	subsequently	ADV
admet-286	24	30	prevents	prevent	VERB
admet-286	24	31	the	the	DET
admet-286	24	32	action	action	NOUN
admet-286	24	33	of	of	ADP
admet-286	24	34	penicillin	penicillin	NOUN
admet-286	24	35	binding	bind	VERB
admet-286	24	36	proteins	protein	NOUN
admet-286	24	37	and	and	CCONJ
admet-286	24	38	stops	stop	VERB
admet-286	24	39	peptidoglycan	peptidoglycan	ADJ
admet-286	24	40	growth	growth	NOUN
admet-286	24	41	(	(	PUNCT
admet-286	24	42	leading	lead	VERB
admet-286	24	43	to	to	ADP
admet-286	24	44	bacterial	bacterial	ADJ
admet-286	24	45	killing	killing	NOUN
admet-286	24	46	)	)	PUNCT
admet-286	24	47	.	.	PUNCT
admet-286	25	1	however	however	ADV
admet-286	25	2	,	,	PUNCT
admet-286	25	3	in	in	ADP
admet-286	25	4	case	case	NOUN
admet-286	25	5	of	of	ADP
admet-286	25	6	resistant	resistant	ADJ
admet-286	25	7	bacteria	bacteria	NOUN
admet-286	25	8	(	(	PUNCT
admet-286	25	9	s.	s.	PROPN
admet-286	25	10	aureus	aureus	PROPN
admet-286	25	11	)	)	PUNCT
admet-286	25	12	,	,	PUNCT
admet-286	25	13	the	the	DET
admet-286	25	14	last	last	ADJ
admet-286	25	15	d	d	NOUN
admet-286	25	16	-	-	PUNCT
admet-286	25	17	alanyl	alanyl	ADJ
admet-286	25	18	moiety	moiety	NOUN
admet-286	25	19	is	be	AUX
admet-286	25	20	replaced	replace	VERB
admet-286	25	21	by	by	ADP
admet-286	25	22	d	d	NOUN
admet-286	25	23	-	-	PUNCT
admet-286	25	24	lactate	lactate	NOUN
admet-286	25	25	,	,	PUNCT
admet-286	25	26	which	which	PRON
admet-286	25	27	makes	make	VERB
admet-286	25	28	bacteria	bacteria	NOUN
admet-286	25	29	less	less	ADV
admet-286	25	30	permeable	permeable	ADJ
admet-286	25	31	to	to	ADP
admet-286	25	32	vancomycin	vancomycin	PROPN
admet-286	25	33	(	(	PUNCT
admet-286	25	34	vancomycin	vancomycin	PROPN
admet-286	25	35	entrapment	entrapment	NOUN
admet-286	25	36	and	and	CCONJ
admet-286	25	37	increase	increase	VERB
admet-286	25	38	membrane	membrane	NOUN
admet-286	25	39	thickness	thickness	NOUN
admet-286	25	40	)	)	PUNCT
admet-286	25	41	.	.	PUNCT
admet-286	26	1	this	this	DET
admet-286	26	2	“	"	PUNCT
admet-286	26	3	permeability	permeability	NOUN
admet-286	26	4	-	-	PUNCT
admet-286	26	5	mediated	mediate	VERB
admet-286	26	6	”	"	PUNCT
admet-286	26	7	resistance	resistance	NOUN
admet-286	26	8	manifested	manifest	VERB
admet-286	26	9	clinically	clinically	ADV
admet-286	26	10	by	by	ADP
admet-286	26	11	treatment	treatment	NOUN
admet-286	26	12	failure	failure	NOUN
admet-286	26	13	or	or	CCONJ
admet-286	26	14	delayed	delay	VERB
admet-286	26	15	resolution	resolution	NOUN
admet-286	26	16	of	of	ADP
admet-286	26	17	s.	s.	PROPN
admet-286	26	18	aureus	aureus	PROPN
admet-286	26	19	infections	infection	NOUN
admet-286	26	20	[	[	X
admet-286	26	21	3,4	3,4	NUM
admet-286	26	22	]	]	PUNCT
admet-286	26	23	.	.	PUNCT
admet-286	27	1	addition	addition	NOUN
admet-286	27	2	of	of	ADP
admet-286	27	3	an	an	DET
admet-286	27	4	antibiotic	antibiotic	NOUN
admet-286	27	5	that	that	PRON
admet-286	27	6	can	can	AUX
admet-286	27	7	resolve	resolve	VERB
admet-286	27	8	the	the	DET
admet-286	27	9	permeability	permeability	NOUN
admet-286	27	10	issue	issue	NOUN
admet-286	27	11	is	be	AUX
admet-286	27	12	a	a	DET
admet-286	27	13	rationale	rationale	NOUN
admet-286	27	14	choice	choice	NOUN
admet-286	27	15	.	.	PUNCT
admet-286	28	1	it	it	PRON
admet-286	28	2	was	be	AUX
admet-286	28	3	demonstrated	demonstrate	VERB
admet-286	28	4	by	by	ADP
admet-286	28	5	our	our	PRON
admet-286	28	6	group	group	NOUN
admet-286	28	7	previously	previously	ADV
admet-286	28	8	[	[	X
admet-286	28	9	5	5	X
admet-286	28	10	]	]	PUNCT
admet-286	28	11	that	that	SCONJ
admet-286	28	12	ceftriaxone	ceftriaxone	PROPN
admet-286	28	13	plus	plus	CCONJ
admet-286	28	14	vancomycin	vancomycin	PROPN
admet-286	28	15	formulation	formulation	NOUN
admet-286	28	16	(	(	PUNCT
admet-286	28	17	2:1	2:1	NUM
admet-286	28	18	w	w	NOUN
admet-286	28	19	/	/	SYM
admet-286	28	20	w	w	NOUN
admet-286	28	21	ratio	ratio	NOUN
admet-286	28	22	)	)	PUNCT
admet-286	28	23	,	,	PUNCT
admet-286	28	24	exploits	exploit	VERB
admet-286	28	25	the	the	DET
admet-286	28	26	virgin	virgin	ADJ
admet-286	28	27	territory	territory	NOUN
admet-286	28	28	of	of	ADP
admet-286	28	29	the	the	DET
admet-286	28	30	vancomycin	vancomycin	PROPN
admet-286	28	31	resistant	resistant	ADJ
admet-286	28	32	bacteria	bacteria	NOUN
admet-286	28	33	i.e.	i.e.	X
admet-286	28	34	penicillin	penicillin	NOUN
admet-286	28	35	binding	bind	VERB
admet-286	28	36	proteins	protein	NOUN
admet-286	28	37	.	.	PUNCT
admet-286	29	1	ceftriaxone	ceftriaxone	PROPN
admet-286	29	2	bind	bind	VERB
admet-286	29	3	irreversibly	irreversibly	ADV
admet-286	29	4	with	with	ADP
admet-286	29	5	these	these	DET
admet-286	29	6	proteins	protein	NOUN
admet-286	29	7	and	and	CCONJ
admet-286	29	8	thus	thus	ADV
admet-286	29	9	inhibit	inhibit	VERB
admet-286	29	10	the	the	DET
admet-286	29	11	transpeptidation	transpeptidation	NOUN
admet-286	29	12	step	step	NOUN
admet-286	29	13	of	of	ADP
admet-286	29	14	peptidoglycan	peptidoglycan	ADJ
admet-286	29	15	synthesis	synthesis	NOUN
admet-286	29	16	to	to	PART
admet-286	29	17	stop	stop	VERB
admet-286	29	18	bacterial	bacterial	ADJ
admet-286	29	19	cell	cell	NOUN
admet-286	29	20	wall	wall	NOUN
admet-286	29	21	growth	growth	NOUN
admet-286	29	22	.	.	PUNCT
admet-286	30	1	ceftriaxone	ceftriaxone	NOUN
admet-286	30	2	-	-	PUNCT
admet-286	30	3	induced	induce	VERB
admet-286	30	4	fragility	fragility	NOUN
admet-286	30	5	in	in	ADP
admet-286	30	6	the	the	DET
admet-286	30	7	peptidoglycan	peptidoglycan	ADJ
admet-286	30	8	layer	layer	NOUN
admet-286	30	9	increases	increase	VERB
admet-286	30	10	the	the	DET
admet-286	30	11	penetrability	penetrability	NOUN
admet-286	30	12	of	of	ADP
admet-286	30	13	the	the	DET
admet-286	30	14	vancomycin	vancomycin	PROPN
admet-286	30	15	and	and	CCONJ
admet-286	30	16	restores	restore	VERB
admet-286	30	17	(	(	PUNCT
admet-286	30	18	to	to	ADP
admet-286	30	19	some	some	DET
admet-286	30	20	extent	extent	NOUN
admet-286	30	21	)	)	PUNCT
admet-286	30	22	its	its	PRON
admet-286	30	23	affinity	affinity	NOUN
admet-286	30	24	towards	towards	ADP
admet-286	30	25	the	the	DET
admet-286	30	26	exposed	expose	VERB
admet-286	30	27	d	d	NOUN
admet-286	30	28	-	-	PUNCT
admet-286	30	29	alanine	alanine	NOUN
admet-286	30	30	moieties	moiety	NOUN
admet-286	30	31	.	.	PUNCT
admet-286	31	1	the	the	DET
admet-286	31	2	'	'	PUNCT
admet-286	31	3	double	double	ADJ
admet-286	31	4	insult	insult	NOUN
admet-286	31	5	'	'	PUNCT
admet-286	31	6	caused	cause	VERB
admet-286	31	7	by	by	ADP
admet-286	31	8	the	the	DET
admet-286	31	9	antibiotic	antibiotic	PROPN
admet-286	31	10	fdc	fdc	PROPN
admet-286	31	11	makes	make	VERB
admet-286	31	12	bacterial	bacterial	ADJ
admet-286	31	13	cell	cell	NOUN
admet-286	31	14	susceptible	susceptible	ADJ
admet-286	31	15	to	to	ADP
admet-286	31	16	death	death	NOUN
admet-286	31	17	.	.	PUNCT
admet-286	32	1	after	after	ADP
admet-286	32	2	pharmacodynamic	pharmacodynamic	ADJ
admet-286	32	3	selection	selection	NOUN
admet-286	32	4	of	of	ADP
admet-286	32	5	drugs	drug	NOUN
admet-286	32	6	combination	combination	NOUN
admet-286	32	7	to	to	ADP
admet-286	32	8	combat	combat	NOUN
admet-286	32	9	mrsa	mrsa	NOUN
admet-286	32	10	,	,	PUNCT
admet-286	32	11	the	the	DET
admet-286	32	12	second	second	ADJ
admet-286	32	13	step	step	NOUN
admet-286	32	14	is	be	AUX
admet-286	32	15	to	to	PART
admet-286	32	16	optimize	optimize	VERB
admet-286	32	17	dose	dose	NOUN
admet-286	32	18	regimens	regimen	NOUN
admet-286	32	19	using	use	VERB
admet-286	32	20	their	their	PRON
admet-286	32	21	pharmacokinetic	pharmacokinetic	ADJ
admet-286	32	22	/	/	SYM
admet-286	32	23	pharmacodynamic	pharmacodynamic	ADJ
admet-286	32	24	(	(	PUNCT
admet-286	32	25	pk	pk	NOUN
admet-286	32	26	/	/	SYM
admet-286	32	27	pd	pd	NOUN
admet-286	32	28	)	)	PUNCT
admet-286	32	29	relationships	relationship	NOUN
admet-286	32	30	[	[	X
admet-286	32	31	6,7	6,7	NUM
admet-286	32	32	]	]	PUNCT
admet-286	32	33	.	.	PUNCT
admet-286	33	1	the	the	DET
admet-286	33	2	dosing	dosing	ADJ
admet-286	33	3	regimens	regimen	NOUN
admet-286	33	4	of	of	ADP
admet-286	33	5	antibiotics	antibiotic	NOUN
admet-286	33	6	are	be	AUX
admet-286	33	7	based	base	VERB
admet-286	33	8	on	on	ADP
admet-286	33	9	mic	mic	ADJ
admet-286	33	10	estimates	estimate	NOUN
admet-286	33	11	(	(	PUNCT
admet-286	33	12	a	a	DET
admet-286	33	13	surrogate	surrogate	ADJ
admet-286	33	14	pd	pd	NOUN
admet-286	33	15	marker	marker	NOUN
admet-286	33	16	for	for	ADP
admet-286	33	17	antibacterial	antibacterial	ADJ
admet-286	33	18	response	response	NOUN
admet-286	33	19	characterization	characterization	NOUN
admet-286	33	20	)	)	PUNCT
admet-286	33	21	and	and	CCONJ
admet-286	33	22	the	the	DET
admet-286	33	23	quantification	quantification	NOUN
admet-286	33	24	of	of	ADP
admet-286	33	25	exposure	exposure	NOUN
admet-286	33	26	(	(	PUNCT
admet-286	33	27	changes	change	NOUN
admet-286	33	28	in	in	ADP
admet-286	33	29	concentration	concentration	NOUN
admet-286	33	30	of	of	ADP
admet-286	33	31	individual	individual	ADJ
admet-286	33	32	components	component	NOUN
admet-286	33	33	of	of	ADP
admet-286	33	34	dose	dose	NOUN
admet-286	33	35	combination	combination	NOUN
admet-286	33	36	)	)	PUNCT
admet-286	33	37	response	response	NOUN
admet-286	33	38	(	(	PUNCT
admet-286	33	39	the	the	DET
admet-286	33	40	reduction	reduction	NOUN
admet-286	33	41	of	of	ADP
admet-286	33	42	bacterial	bacterial	ADJ
admet-286	33	43	count	count	NOUN
admet-286	33	44	)	)	PUNCT
admet-286	33	45	relationship	relationship	NOUN
admet-286	34	1	[	[	X
admet-286	34	2	6,7	6,7	NUM
admet-286	34	3	]	]	PUNCT
admet-286	34	4	.	.	PUNCT
admet-286	35	1	the	the	DET
admet-286	35	2	exposure	exposure	NOUN
admet-286	35	3	-	-	PUNCT
admet-286	35	4	response	response	NOUN
admet-286	35	5	relationships	relationship	NOUN
admet-286	35	6	help	help	VERB
admet-286	35	7	in	in	ADP
admet-286	35	8	evaluating	evaluate	VERB
admet-286	35	9	the	the	DET
admet-286	35	10	pk	pk	NOUN
admet-286	35	11	/	/	SYM
admet-286	35	12	pd	pd	PROPN
admet-286	35	13	indices	index	NOUN
admet-286	36	1	[	[	X
admet-286	36	2	8,9	8,9	NUM
admet-286	36	3	]	]	PUNCT
admet-286	36	4	and	and	CCONJ
admet-286	36	5	further	far	ADV
admet-286	36	6	identifying	identify	VERB
admet-286	36	7	the	the	DET
admet-286	36	8	efficacy	efficacy	NOUN
admet-286	36	9	drivers	driver	NOUN
admet-286	36	10	for	for	ADP
admet-286	36	11	understanding	understand	VERB
admet-286	36	12	the	the	DET
admet-286	36	13	potential	potential	ADJ
admet-286	36	14	activity	activity	NOUN
admet-286	36	15	of	of	ADP
admet-286	36	16	antibacterial	antibacterial	ADJ
admet-286	36	17	agents	agent	NOUN
admet-286	36	18	.	.	PUNCT
admet-286	37	1	the	the	DET
admet-286	37	2	three	three	NUM
admet-286	37	3	pk	pk	NOUN
admet-286	37	4	/	/	SYM
admet-286	37	5	pd	pd	PROPN
admet-286	37	6	indices	index	NOUN
admet-286	37	7	that	that	PRON
admet-286	37	8	are	be	AUX
admet-286	37	9	routinely	routinely	ADV
admet-286	37	10	used	use	VERB
admet-286	37	11	for	for	ADP
admet-286	37	12	explaining	explain	VERB
admet-286	37	13	the	the	DET
admet-286	37	14	therapeutic	therapeutic	ADJ
admet-286	37	15	efficacy	efficacy	NOUN
admet-286	37	16	in	in	ADP
admet-286	37	17	terms	term	NOUN
admet-286	37	18	of	of	ADP
admet-286	37	19	achieving	achieve	VERB
admet-286	37	20	mic	mic	ADJ
admet-286	37	21	and	and	CCONJ
admet-286	37	22	mechanism	mechanism	NOUN
admet-286	37	23	based	base	VERB
admet-286	37	24	action	action	NOUN
admet-286	37	25	of	of	ADP
admet-286	37	26	antibiotics	antibiotic	NOUN
admet-286	37	27	include	include	VERB
admet-286	37	28	:	:	PUNCT
admet-286	37	29	1	1	X
admet-286	37	30	)	)	PUNCT
admet-286	37	31	%	%	NOUN
admet-286	37	32	t	t	PROPN
admet-286	37	33	>	>	X
admet-286	37	34	mic	mic	ADJ
admet-286	37	35	time	time	NOUN
admet-286	37	36	(	(	PUNCT
admet-286	37	37	%	%	INTJ
admet-286	37	38	time	time	NOUN
admet-286	37	39	for	for	ADP
admet-286	37	40	which	which	PRON
admet-286	37	41	the	the	DET
admet-286	37	42	levels	level	NOUN
admet-286	37	43	of	of	ADP
admet-286	37	44	antibiotic	antibiotic	NOUN
admet-286	37	45	in	in	ADP
admet-286	37	46	serum	serum	NOUN
admet-286	37	47	/	/	SYM
admet-286	37	48	plasma	plasma	NOUN
admet-286	37	49	exceed	exceed	VERB
admet-286	37	50	the	the	DET
admet-286	37	51	mic	mic	NOUN
admet-286	37	52	)	)	PUNCT
admet-286	37	53	;	;	PUNCT
admet-286	37	54	2	2	X
admet-286	37	55	)	)	PUNCT
admet-286	37	56	area	area	NOUN
admet-286	37	57	under	under	ADP
admet-286	37	58	the	the	DET
admet-286	37	59	concentration	concentration	NOUN
admet-286	37	60	-	-	PUNCT
admet-286	37	61	time	time	NOUN
admet-286	37	62	curve	curve	NOUN
admet-286	37	63	(	(	PUNCT
admet-286	37	64	auc)/mic	auc)/mic	ADJ
admet-286	37	65	ratio	ratio	NOUN
admet-286	37	66	;	;	PUNCT
admet-286	37	67	3	3	X
admet-286	37	68	)	)	PUNCT
admet-286	37	69	peak	peak	NOUN
admet-286	37	70	plasma	plasma	NOUN
admet-286	37	71	concentration	concentration	NOUN
admet-286	37	72	(	(	PUNCT
admet-286	37	73	cmax)/mic	cmax)/mic	ADJ
admet-286	37	74	ratio	ratio	NOUN
admet-286	37	75	[	[	X
admet-286	37	76	10	10	NUM
admet-286	37	77	-	-	SYM
admet-286	37	78	12	12	NUM
admet-286	37	79	]	]	PUNCT
admet-286	37	80	.	.	PUNCT
admet-286	38	1	maximum	maximum	PROPN
admet-286	38	2	literature	literature	PROPN
admet-286	38	3	for	for	ADP
admet-286	38	4	these	these	DET
admet-286	38	5	kinds	kind	NOUN
admet-286	38	6	of	of	ADP
admet-286	38	7	pk	pk	NOUN
admet-286	38	8	/	/	SYM
admet-286	38	9	pd	pd	PROPN
admet-286	38	10	studies	study	NOUN
admet-286	38	11	is	be	AUX
admet-286	38	12	available	available	ADJ
admet-286	38	13	for	for	ADP
admet-286	38	14	single	single	ADJ
admet-286	38	15	antibacterial	antibacterial	ADJ
admet-286	38	16	agents	agent	NOUN
admet-286	38	17	[	[	X
admet-286	38	18	13,14	13,14	NUM
admet-286	38	19	]	]	X
admet-286	38	20	;	;	PUNCT
admet-286	38	21	the	the	DET
admet-286	38	22	effect	effect	NOUN
admet-286	38	23	of	of	ADP
admet-286	38	24	combination	combination	NOUN
admet-286	38	25	therapy	therapy	NOUN
admet-286	38	26	on	on	ADP
admet-286	38	27	the	the	DET
admet-286	38	28	pk	pk	NOUN
admet-286	38	29	and	and	CCONJ
admet-286	38	30	pd	pd	NOUN
admet-286	38	31	,	,	PUNCT
admet-286	38	32	and	and	CCONJ
admet-286	38	33	subsequently	subsequently	ADV
admet-286	38	34	on	on	ADP
admet-286	38	35	pk	pk	NOUN
admet-286	38	36	/	/	SYM
admet-286	38	37	pd	pd	PROPN
admet-286	38	38	indices	index	NOUN
admet-286	38	39	is	be	AUX
admet-286	38	40	very	very	ADV
admet-286	38	41	limited	limited	ADJ
admet-286	38	42	[	[	X
admet-286	38	43	15	15	NUM
admet-286	38	44	]	]	PUNCT
admet-286	38	45	.	.	PUNCT
admet-286	39	1	the	the	DET
admet-286	39	2	active	active	ADJ
admet-286	39	3	components	component	NOUN
admet-286	39	4	of	of	ADP
admet-286	39	5	the	the	DET
admet-286	39	6	fixed	fix	VERB
admet-286	39	7	dose	dose	NOUN
admet-286	39	8	combination	combination	NOUN
admet-286	39	9	(	(	PUNCT
admet-286	39	10	fdc	fdc	PROPN
admet-286	39	11	)	)	PUNCT
admet-286	39	12	i.e.	i.e.	X
admet-286	39	13	vancomycin	vancomycin	PROPN
admet-286	39	14	(	(	PUNCT
admet-286	39	15	auc	auc	NOUN
admet-286	39	16	/	/	SYM
admet-286	39	17	mic	mic	ADJ
admet-286	39	18	ratio	ratio	NOUN
admet-286	39	19	is	be	AUX
admet-286	39	20	the	the	DET
admet-286	39	21	preferred	preferred	ADJ
admet-286	39	22	index	index	NOUN
admet-286	39	23	)	)	PUNCT
admet-286	39	24	and	and	CCONJ
admet-286	39	25	ceftriaxone	ceftriaxone	PROPN
admet-286	40	1	(	(	PUNCT
admet-286	40	2	%	%	INTJ
admet-286	40	3	t	t	X
admet-286	40	4	>	>	X
admet-286	40	5	mic	mic	NOUN
admet-286	40	6	is	be	AUX
admet-286	40	7	the	the	DET
admet-286	40	8	preferred	preferred	ADJ
admet-286	40	9	index	index	NOUN
admet-286	40	10	)	)	PUNCT
admet-286	40	11	have	have	VERB
admet-286	40	12	similar	similar	ADJ
admet-286	40	13	pk	pk	NOUN
admet-286	40	14	profiles	profile	NOUN
admet-286	40	15	but	but	CCONJ
admet-286	40	16	their	their	PRON
admet-286	40	17	optimized	optimize	VERB
admet-286	40	18	pk	pk	NOUN
admet-286	40	19	/	/	SYM
admet-286	40	20	pd	pd	PROPN
admet-286	40	21	indices	index	NOUN
admet-286	40	22	correlative	correlative	ADJ
admet-286	40	23	of	of	ADP
admet-286	40	24	therapeutic	therapeutic	ADJ
admet-286	40	25	efficacy	efficacy	NOUN
admet-286	40	26	are	be	AUX
admet-286	40	27	different	different	ADJ
admet-286	40	28	.	.	PUNCT
admet-286	41	1	the	the	DET
admet-286	41	2	parameters	parameter	NOUN
admet-286	41	3	which	which	PRON
admet-286	41	4	are	be	AUX
admet-286	41	5	usually	usually	ADV
admet-286	41	6	used	use	VERB
admet-286	41	7	to	to	PART
admet-286	41	8	show	show	VERB
admet-286	41	9	antibiotic	antibiotic	ADJ
admet-286	41	10	interactions	interaction	NOUN
admet-286	41	11	for	for	ADP
admet-286	41	12	combination	combination	NOUN
admet-286	41	13	therapy	therapy	NOUN
admet-286	41	14	are	be	AUX
admet-286	41	15	fic	fic	ADJ
admet-286	41	16	(	(	PUNCT
admet-286	41	17	fractional	fractional	ADJ
admet-286	41	18	inhibitory	inhibitory	ADJ
admet-286	41	19	concentration	concentration	NOUN
admet-286	41	20	)	)	PUNCT
admet-286	41	21	indices	index	NOUN
admet-286	41	22	.	.	PUNCT
admet-286	42	1	through	through	ADP
admet-286	42	2	this	this	DET
admet-286	42	3	approach	approach	NOUN
admet-286	42	4	,	,	PUNCT
admet-286	42	5	the	the	DET
admet-286	42	6	synergism	synergism	NOUN
admet-286	42	7	or	or	CCONJ
admet-286	42	8	antagonism	antagonism	NOUN
admet-286	42	9	expressed	express	VERB
admet-286	42	10	as	as	SCONJ
admet-286	42	11	the	the	DET
admet-286	42	12	maximum	maximum	ADJ
admet-286	42	13	effect	effect	NOUN
admet-286	42	14	of	of	ADP
admet-286	42	15	the	the	DET
admet-286	42	16	antibiotic	antibiotic	ADJ
admet-286	42	17	combination	combination	NOUN
admet-286	42	18	can	can	AUX
admet-286	42	19	be	be	AUX
admet-286	42	20	calculated	calculate	VERB
admet-286	42	21	(	(	PUNCT
admet-286	42	22	fic	fic	ADJ
admet-286	42	23	index	index	NOUN
admet-286	42	24	identified	identify	VERB
admet-286	42	25	for	for	ADP
admet-286	42	26	this	this	DET
admet-286	42	27	combination	combination	NOUN
admet-286	42	28	was	be	AUX
admet-286	42	29	<	<	X
admet-286	42	30	0.5	0.5	NUM
admet-286	42	31	suggesting	suggest	VERB
admet-286	42	32	synergistic	synergistic	ADJ
admet-286	42	33	pharmacodynamic	pharmacodynamic	ADJ
admet-286	42	34	action	action	NOUN
admet-286	42	35	[	[	X
admet-286	42	36	5	5	NUM
admet-286	42	37	]	]	PUNCT
admet-286	42	38	,	,	PUNCT
admet-286	42	39	and	and	CCONJ
admet-286	42	40	estimations	estimation	NOUN
admet-286	42	41	of	of	ADP
admet-286	42	42	pk	pk	NOUN
admet-286	42	43	/	/	SYM
admet-286	42	44	pd	pd	NOUN
admet-286	42	45	index	index	NOUN
admet-286	42	46	on	on	ADP
admet-286	42	47	the	the	DET
admet-286	42	48	basis	basis	NOUN
admet-286	42	49	of	of	ADP
admet-286	42	50	fics	fic	NOUN
admet-286	42	51	are	be	AUX
admet-286	42	52	considered	consider	VERB
admet-286	42	53	as	as	ADP
admet-286	42	54	composite	composite	ADJ
admet-286	42	55	predictors	predictor	NOUN
admet-286	42	56	.	.	PUNCT
admet-286	43	1	the	the	DET
admet-286	43	2	purpose	purpose	NOUN
admet-286	43	3	of	of	ADP
admet-286	43	4	the	the	DET
admet-286	43	5	present	present	ADJ
admet-286	43	6	study	study	NOUN
admet-286	43	7	is	be	AUX
admet-286	43	8	to	to	PART
admet-286	43	9	use	use	VERB
admet-286	43	10	in	in	ADP
admet-286	43	11	-	-	PUNCT
admet-286	43	12	silico	silico	NOUN
admet-286	43	13	pk	pk	NOUN
admet-286	43	14	/	/	SYM
admet-286	43	15	pd	pd	NOUN
admet-286	43	16	modeling	modeling	NOUN
admet-286	43	17	and	and	CCONJ
admet-286	43	18	simulations	simulation	NOUN
admet-286	43	19	strategies	strategy	NOUN
admet-286	43	20	to	to	PART
admet-286	43	21	identify	identify	VERB
admet-286	43	22	the	the	DET
admet-286	43	23	fic	fic	NOUN
admet-286	43	24	based	base	VERB
admet-286	43	25	pk	pk	PROPN
admet-286	43	26	/	/	SYM
admet-286	43	27	pd	pd	PROPN
admet-286	43	28	indices	index	NOUN
admet-286	43	29	that	that	PRON
admet-286	43	30	can	can	AUX
admet-286	43	31	predict	predict	VERB
admet-286	43	32	the	the	DET
admet-286	43	33	therapeutic	therapeutic	ADJ
admet-286	43	34	efficacy	efficacy	NOUN
admet-286	43	35	of	of	ADP
admet-286	43	36	combination	combination	NOUN
admet-286	43	37	therapy	therapy	NOUN
admet-286	43	38	and	and	CCONJ
admet-286	43	39	further	further	ADJ
admet-286	43	40	help	help	NOUN
admet-286	43	41	in	in	ADP
admet-286	43	42	optimization	optimization	NOUN
admet-286	43	43	of	of	ADP
admet-286	43	44	dosage	dosage	NOUN
admet-286	43	45	regimen	regiman	NOUN
admet-286	43	46	(	(	PUNCT
admet-286	43	47	figure	figure	NOUN
admet-286	43	48	1	1	NUM
admet-286	43	49	)	)	PUNCT
admet-286	44	1	[	[	X
admet-286	44	2	16	16	NUM
admet-286	44	3	]	]	PUNCT
admet-286	44	4	.	.	PUNCT
admet-286	45	1	after	after	ADP
admet-286	45	2	identification	identification	NOUN
admet-286	45	3	of	of	ADP
admet-286	45	4	best	good	ADJ
admet-286	45	5	pk	pk	NOUN
admet-286	45	6	/	/	SYM
admet-286	45	7	pd	pd	NOUN
admet-286	45	8	index	index	NOUN
admet-286	45	9	driving	drive	VERB
admet-286	45	10	the	the	DET
admet-286	45	11	therapeutic	therapeutic	ADJ
admet-286	45	12	outcome	outcome	NOUN
admet-286	45	13	,	,	PUNCT
admet-286	45	14	monte	monte	PROPN
admet-286	45	15	carlo	carlo	PROPN
admet-286	45	16	simulations	simulation	NOUN
admet-286	45	17	were	be	AUX
admet-286	45	18	performed	perform	VERB
admet-286	45	19	to	to	PART
admet-286	45	20	understand	understand	VERB
admet-286	45	21	the	the	DET
admet-286	45	22	clinical	clinical	ADJ
admet-286	45	23	admet	admet	NOUN
admet-286	45	24	&	&	CCONJ
admet-286	45	25	dmpk	dmpk	PROPN
admet-286	45	26	4(3	4(3	NUM
admet-286	45	27	)	)	PUNCT
admet-286	45	28	(	(	PUNCT
admet-286	45	29	2016	2016	NUM
admet-286	45	30	)	)	PUNCT
admet-286	45	31	241	241	NUM
admet-286	45	32	-	-	SYM
admet-286	45	33	260	260	NUM
admet-286	45	34	dose	dose	NOUN
admet-286	45	35	optimization	optimization	NOUN
admet-286	45	36	of	of	ADP
admet-286	45	37	fdc	fdc	PROPN
admet-286	45	38	against	against	ADP
admet-286	45	39	s.	s.	PROPN
admet-286	45	40	aureus	aureus	PROPN
admet-286	45	41	resistant	resistant	ADJ
admet-286	45	42	bacteria	bacteria	NOUN
admet-286	45	43	doi	doi	NOUN
admet-286	45	44	:	:	PUNCT
admet-286	45	45	10.5599	10.5599	NUM
admet-286	45	46	/	/	SYM
admet-286	45	47	admet.4.3.286	admet.4.3.286	VERB
admet-286	45	48	243	243	NUM
admet-286	45	49	benefit	benefit	NOUN
admet-286	45	50	of	of	ADP
admet-286	45	51	the	the	DET
admet-286	45	52	fdc	fdc	PROPN
admet-286	45	53	and	and	CCONJ
admet-286	45	54	1000	1000	NUM
admet-286	45	55	subjects	subject	NOUN
admet-286	45	56	’	'	PUNCT
admet-286	45	57	simulated	simulate	VERB
admet-286	45	58	data	datum	NOUN
admet-286	45	59	was	be	AUX
admet-286	45	60	generated	generate	VERB
admet-286	45	61	using	use	VERB
admet-286	45	62	population	population	NOUN
admet-286	45	63	pk	pk	NOUN
admet-286	45	64	parameters	parameter	NOUN
admet-286	45	65	of	of	ADP
admet-286	45	66	individual	individual	ADJ
admet-286	45	67	components	component	NOUN
admet-286	45	68	of	of	ADP
admet-286	45	69	the	the	DET
admet-286	45	70	fdc	fdc	PROPN
admet-286	46	1	[	[	X
admet-286	46	2	17	17	NUM
admet-286	46	3	]	]	PUNCT
admet-286	46	4	.	.	PUNCT
admet-286	47	1	the	the	PRON
admet-286	47	2	pta	pta	PROPN
admet-286	47	3	(	(	PUNCT
admet-286	47	4	probability	probability	NOUN
admet-286	47	5	of	of	ADP
admet-286	47	6	target	target	NOUN
admet-286	47	7	attainment	attainment	NOUN
admet-286	47	8	)	)	PUNCT
admet-286	47	9	of	of	ADP
admet-286	47	10	pk	pk	PROPN
admet-286	47	11	/	/	SYM
admet-286	47	12	pd	pd	NOUN
admet-286	47	13	index	index	NOUN
admet-286	47	14	in	in	ADP
admet-286	47	15	the	the	DET
admet-286	47	16	simulated	simulate	VERB
admet-286	47	17	data	datum	NOUN
admet-286	47	18	was	be	AUX
admet-286	47	19	calculated	calculate	VERB
admet-286	47	20	and	and	CCONJ
admet-286	47	21	the	the	DET
admet-286	47	22	clinical	clinical	ADJ
admet-286	47	23	breakpoint	breakpoint	NOUN
admet-286	47	24	of	of	ADP
admet-286	47	25	the	the	DET
admet-286	47	26	fdc	fdc	PROPN
admet-286	47	27	was	be	AUX
admet-286	47	28	identified	identify	VERB
admet-286	47	29	.	.	PUNCT
admet-286	48	1	the	the	DET
admet-286	48	2	breakpoint	breakpoint	NOUN
admet-286	48	3	analysis	analysis	NOUN
admet-286	48	4	will	will	AUX
admet-286	48	5	not	not	PART
admet-286	48	6	only	only	ADV
admet-286	48	7	help	help	VERB
admet-286	48	8	us	we	PRON
admet-286	48	9	in	in	ADP
admet-286	48	10	optimizing	optimize	VERB
admet-286	48	11	the	the	DET
admet-286	48	12	use	use	NOUN
admet-286	48	13	of	of	ADP
admet-286	48	14	antibiotic	antibiotic	ADJ
admet-286	48	15	combination	combination	NOUN
admet-286	48	16	,	,	PUNCT
admet-286	48	17	but	but	CCONJ
admet-286	48	18	also	also	ADV
admet-286	48	19	in	in	ADP
admet-286	48	20	identifying	identify	VERB
admet-286	48	21	the	the	DET
admet-286	48	22	differences	difference	NOUN
admet-286	48	23	in	in	ADP
admet-286	48	24	resistance	resistance	NOUN
admet-286	48	25	pattern	pattern	NOUN
admet-286	48	26	for	for	ADP
admet-286	48	27	ceftriaxone	ceftriaxone	PROPN
admet-286	48	28	/	/	SYM
admet-286	48	29	vancomycin	vancomycin	PROPN
admet-286	48	30	(	(	PUNCT
admet-286	48	31	2/1	2/1	NUM
admet-286	48	32	)	)	PUNCT
admet-286	48	33	in	in	ADP
admet-286	48	34	comparison	comparison	NOUN
admet-286	48	35	to	to	ADP
admet-286	48	36	vancomycin	vancomycin	PROPN
admet-286	48	37	alone	alone	ADV
admet-286	48	38	.	.	PUNCT
admet-286	49	1	figure	figure	VERB
admet-286	49	2	1	1	NUM
admet-286	49	3	.	.	PUNCT
admet-286	50	1	schematics	schematic	NOUN
admet-286	50	2	of	of	ADP
admet-286	50	3	the	the	DET
admet-286	50	4	approach	approach	NOUN
admet-286	50	5	used	use	VERB
admet-286	50	6	in	in	ADP
admet-286	50	7	the	the	DET
admet-286	50	8	study	study	NOUN
admet-286	50	9	.	.	PUNCT
admet-286	51	1	in	in	ADP
admet-286	51	2	vitro	vitro	X
admet-286	51	3	studies	study	NOUN
admet-286	51	4	were	be	AUX
admet-286	51	5	performed	perform	VERB
admet-286	51	6	to	to	PART
admet-286	51	7	study	study	VERB
admet-286	51	8	exposureresponse	exposureresponse	NOUN
admet-286	51	9	relationships	relationship	NOUN
admet-286	51	10	and	and	CCONJ
admet-286	51	11	pk	pk	NOUN
admet-286	51	12	/	/	SYM
admet-286	51	13	pd	pd	NOUN
admet-286	51	14	driver	driver	NOUN
admet-286	51	15	identification	identification	NOUN
admet-286	51	16	.	.	PUNCT
admet-286	52	1	using	use	VERB
admet-286	52	2	the	the	DET
admet-286	52	3	information	information	NOUN
admet-286	52	4	of	of	ADP
admet-286	52	5	in	in	ADP
admet-286	52	6	vitro	vitro	X
admet-286	52	7	studies	study	NOUN
admet-286	52	8	,	,	PUNCT
admet-286	52	9	three	three	NUM
admet-286	52	10	approaches	approach	NOUN
admet-286	52	11	i.e.	i.e.	X
admet-286	52	12	in	in	ADP
admet-286	52	13	vitro	vitro	X
admet-286	52	14	studies	study	NOUN
admet-286	52	15	,	,	PUNCT
admet-286	52	16	pk	pk	NOUN
admet-286	52	17	/	/	SYM
admet-286	52	18	pd	pd	NOUN
admet-286	52	19	modeling	modeling	NOUN
admet-286	52	20	and	and	CCONJ
admet-286	52	21	monte	monte	PROPN
admet-286	52	22	carlo	carlo	PROPN
admet-286	52	23	simulations	simulation	NOUN
admet-286	52	24	were	be	AUX
admet-286	52	25	employed	employ	VERB
admet-286	52	26	for	for	ADP
admet-286	52	27	dose	dose	NOUN
admet-286	52	28	recommendations	recommendation	NOUN
admet-286	52	29	.	.	PUNCT
admet-286	53	1	materials	material	NOUN
admet-286	53	2	and	and	CCONJ
admet-286	53	3	methods	method	NOUN
admet-286	53	4	antibiotics	antibiotic	NOUN
admet-286	53	5	,	,	PUNCT
admet-286	53	6	bacteria	bacteria	NOUN
admet-286	53	7	,	,	PUNCT
admet-286	53	8	and	and	CCONJ
admet-286	53	9	media	media	VERB
admet-286	53	10	the	the	DET
admet-286	53	11	fdc	fdc	PROPN
admet-286	53	12	of	of	ADP
admet-286	53	13	ceftriaxone	ceftriaxone	PROPN
admet-286	53	14	/	/	SYM
admet-286	53	15	vancomycin	vancomycin	PROPN
admet-286	53	16	(	(	PUNCT
admet-286	53	17	2/1	2/1	NUM
admet-286	53	18	)	)	PUNCT
admet-286	53	19	vials	vial	NOUN
admet-286	53	20	(	(	PUNCT
admet-286	53	21	vancoplus	vancoplus	NOUN
admet-286	53	22	)	)	PUNCT
admet-286	53	23	were	be	AUX
admet-286	53	24	obtained	obtain	VERB
admet-286	53	25	from	from	ADP
admet-286	53	26	venus	venus	PROPN
admet-286	53	27	remedies	remedies	PROPN
admet-286	53	28	ltd	ltd	PROPN
admet-286	53	29	,	,	PUNCT
admet-286	53	30	h.p	h.p	PROPN
admet-286	53	31	.	.	PROPN
admet-286	53	32	,	,	PUNCT
admet-286	53	33	india	india	PROPN
admet-286	53	34	.	.	PUNCT
admet-286	54	1	genotypically	genotypically	PROPN
admet-286	54	2	characterized	characterize	VERB
admet-286	54	3	mrsa	mrsa	NOUN
admet-286	54	4	clinical	clinical	ADJ
admet-286	54	5	isolates	isolate	NOUN
admet-286	54	6	with	with	ADP
admet-286	54	7	reduced	reduced	ADJ
admet-286	54	8	susceptibility	susceptibility	NOUN
admet-286	54	9	to	to	ADP
admet-286	54	10	vancomycin	vancomycin	PROPN
admet-286	54	11	were	be	AUX
admet-286	54	12	taken	take	VERB
admet-286	54	13	from	from	ADP
admet-286	54	14	clinical	clinical	ADJ
admet-286	54	15	isolate	isolate	PROPN
admet-286	54	16	bank	bank	PROPN
admet-286	54	17	of	of	ADP
admet-286	54	18	venus	venus	PROPN
admet-286	54	19	medicine	medicine	NOUN
admet-286	54	20	research	research	NOUN
admet-286	54	21	centre	centre	NOUN
admet-286	54	22	,	,	PUNCT
admet-286	54	23	baddi	baddi	NOUN
admet-286	54	24	.	.	PUNCT
admet-286	55	1	the	the	DET
admet-286	55	2	media	media	PROPN
admet-286	55	3	mueller	mueller	PROPN
admet-286	55	4	-	-	PUNCT
admet-286	55	5	hinton	hinton	PROPN
admet-286	55	6	broth	broth	NOUN
admet-286	55	7	(	(	PUNCT
admet-286	55	8	becton	becton	PROPN
admet-286	55	9	dickinson	dickinson	PROPN
admet-286	55	10	,	,	PUNCT
admet-286	55	11	sparks	spark	VERB
admet-286	55	12	,	,	PUNCT
admet-286	55	13	md	md	PROPN
admet-286	55	14	)	)	PUNCT
admet-286	55	15	was	be	AUX
admet-286	55	16	used	use	VERB
admet-286	55	17	to	to	PART
admet-286	55	18	perform	perform	VERB
admet-286	55	19	all	all	PRON
admet-286	55	20	in	in	ADV
admet-286	55	21	vitro	vitro	X
admet-286	55	22	studies	study	NOUN
admet-286	55	23	involving	involve	VERB
admet-286	55	24	mic	mic	ADJ
admet-286	55	25	determination	determination	NOUN
admet-286	55	26	,	,	PUNCT
admet-286	55	27	bacterial	bacterial	ADJ
admet-286	55	28	kinetics	kinetic	NOUN
admet-286	55	29	,	,	PUNCT
admet-286	55	30	dose	dose	NOUN
admet-286	55	31	ranging	ranging	NOUN
admet-286	55	32	,	,	PUNCT
admet-286	55	33	fractionation	fractionation	NOUN
admet-286	55	34	,	,	PUNCT
admet-286	55	35	and	and	CCONJ
admet-286	55	36	response	response	NOUN
admet-286	55	37	studies	study	NOUN
admet-286	55	38	.	.	PUNCT
admet-286	56	1	quantification	quantification	NOUN
admet-286	56	2	of	of	ADP
admet-286	56	3	bacteria	bacteria	NOUN
admet-286	56	4	and	and	CCONJ
admet-286	56	5	antibiotic	antibiotic	ADJ
admet-286	56	6	the	the	DET
admet-286	56	7	bacterial	bacterial	ADJ
admet-286	56	8	density	density	NOUN
admet-286	56	9	(	(	PUNCT
admet-286	56	10	cfu	cfu	X
admet-286	56	11	[	[	X
admet-286	56	12	colony	colony	NOUN
admet-286	56	13	forming	form	VERB
admet-286	56	14	units	unit	NOUN
admet-286	56	15	]	]	PUNCT
admet-286	56	16	)	)	PUNCT
admet-286	56	17	and	and	CCONJ
admet-286	56	18	mic	mic	ADJ
admet-286	56	19	determinations	determination	NOUN
admet-286	56	20	were	be	AUX
admet-286	56	21	conducted	conduct	VERB
admet-286	56	22	according	accord	VERB
admet-286	56	23	to	to	ADP
admet-286	56	24	clinical	clinical	ADJ
admet-286	56	25	laboratory	laboratory	NOUN
admet-286	56	26	standard	standard	PROPN
admet-286	56	27	institute	institute	PROPN
admet-286	56	28	guidelines	guideline	NOUN
admet-286	56	29	[	[	X
admet-286	56	30	18	18	NUM
admet-286	56	31	]	]	PUNCT
admet-286	56	32	.	.	PUNCT
admet-286	57	1	the	the	DET
admet-286	57	2	fic	fic	ADJ
admet-286	57	3	index	index	NOUN
admet-286	57	4	was	be	AUX
admet-286	57	5	determined	determine	VERB
admet-286	57	6	using	use	VERB
admet-286	57	7	checkerboard	checkerboard	NOUN
admet-286	57	8	method	method	NOUN
admet-286	57	9	[	[	X
admet-286	57	10	5	5	NUM
admet-286	57	11	]	]	PUNCT
admet-286	57	12	.	.	PUNCT
admet-286	58	1	the	the	DET
admet-286	58	2	media	media	NOUN
admet-286	58	3	samples	sample	NOUN
admet-286	58	4	were	be	AUX
admet-286	58	5	analyzed	analyze	VERB
admet-286	58	6	for	for	ADP
admet-286	58	7	ceftriaxone	ceftriaxone	NOUN
admet-286	58	8	and	and	CCONJ
admet-286	58	9	vancomycin	vancomycin	PROPN
admet-286	58	10	concentrations	concentration	NOUN
admet-286	58	11	using	use	VERB
admet-286	58	12	high	high	ADJ
admet-286	58	13	performance	performance	NOUN
admet-286	58	14	liquid	liquid	NOUN
admet-286	58	15	chromatography	chromatography	NOUN
admet-286	58	16	,	,	PUNCT
admet-286	58	17	as	as	SCONJ
admet-286	58	18	mentioned	mention	VERB
admet-286	58	19	in	in	ADP
admet-286	58	20	our	our	PRON
admet-286	58	21	previous	previous	ADJ
admet-286	58	22	article	article	NOUN
admet-286	58	23	[	[	X
admet-286	58	24	19	19	NUM
admet-286	58	25	]	]	PUNCT
admet-286	58	26	.	.	PUNCT
admet-286	59	1	one	one	NUM
admet-286	59	2	-	-	PUNCT
admet-286	59	3	compartment	compartment	NOUN
admet-286	59	4	chemostat	chemostat	NOUN
admet-286	59	5	infection	infection	NOUN
admet-286	59	6	model	model	NOUN
admet-286	59	7	single	single	ADJ
admet-286	59	8	-	-	PUNCT
admet-286	59	9	compartment	compartment	NOUN
admet-286	59	10	chemostat	chemostat	NOUN
admet-286	59	11	infection	infection	NOUN
admet-286	59	12	system	system	NOUN
admet-286	59	13	as	as	SCONJ
admet-286	59	14	described	describe	VERB
admet-286	59	15	previously	previously	ADV
admet-286	59	16	[	[	X
admet-286	59	17	14,20,21	14,20,21	NUM
admet-286	59	18	]	]	PUNCT
admet-286	59	19	was	be	AUX
admet-286	59	20	used	use	VERB
admet-286	59	21	for	for	ADP
admet-286	59	22	the	the	DET
admet-286	59	23	in	in	X
admet-286	59	24	vitro	vitro	X
admet-286	59	25	modeling	modeling	NOUN
admet-286	59	26	of	of	ADP
admet-286	59	27	the	the	DET
admet-286	59	28	fdc	fdc	PROPN
admet-286	59	29	.	.	PUNCT
admet-286	60	1	in	in	ADP
admet-286	60	2	summary	summary	NOUN
admet-286	60	3	,	,	PUNCT
admet-286	60	4	the	the	DET
admet-286	60	5	chemostat	chemostat	NOUN
admet-286	60	6	system	system	NOUN
admet-286	60	7	assembly	assembly	NOUN
admet-286	60	8	consisted	consist	VERB
admet-286	60	9	of	of	ADP
admet-286	60	10	a	a	DET
admet-286	60	11	500	500	NUM
admet-286	60	12	ml	ml	NOUN
admet-286	60	13	glass	glass	NOUN
admet-286	60	14	central	central	PROPN
admet-286	60	15	reservoir	reservoir	PROPN
admet-286	60	16	chamber	chamber	PROPN
admet-286	60	17	with	with	ADP
admet-286	60	18	five	five	NUM
admet-286	60	19	ports	port	NOUN
admet-286	60	20	for	for	ADP
admet-286	60	21	the	the	DET
admet-286	60	22	addition	addition	NOUN
admet-286	60	23	and	and	CCONJ
admet-286	60	24	removal	removal	NOUN
admet-286	60	25	of	of	ADP
admet-286	60	26	media	medium	NOUN
admet-286	60	27	via	via	ADP
admet-286	60	28	silicone	silicone	NOUN
admet-286	60	29	tubes	tube	NOUN
admet-286	60	30	connected	connect	VERB
admet-286	60	31	to	to	ADP
admet-286	60	32	peristaltic	peristaltic	ADJ
admet-286	60	33	pumps	pump	NOUN
admet-286	60	34	,	,	PUNCT
admet-286	60	35	injection	injection	NOUN
admet-286	60	36	of	of	ADP
admet-286	60	37	drug	drug	NOUN
admet-286	60	38	(	(	PUNCT
admet-286	60	39	antibiotic	antibiotic	ADJ
admet-286	60	40	combination	combination	NOUN
admet-286	60	41	)	)	PUNCT
admet-286	60	42	solution	solution	NOUN
admet-286	60	43	,	,	PUNCT
admet-286	60	44	and	and	CCONJ
admet-286	60	45	removal	removal	NOUN
admet-286	60	46	of	of	ADP
admet-286	60	47	medium	medium	ADJ
admet-286	60	48	samples	sample	NOUN
admet-286	60	49	.	.	PUNCT
admet-286	61	1	prior	prior	ADV
admet-286	61	2	to	to	ADP
admet-286	61	3	each	each	DET
admet-286	61	4	experiment	experiment	NOUN
admet-286	61	5	,	,	PUNCT
admet-286	61	6	mrsa	mrsa	NOUN
admet-286	61	7	colonies	colony	NOUN
admet-286	61	8	were	be	AUX
admet-286	61	9	grown	grow	VERB
admet-286	61	10	overnight	overnight	ADV
admet-286	61	11	to	to	PART
admet-286	61	12	obtain	obtain	VERB
admet-286	61	13	a	a	DET
admet-286	61	14	starting	starting	NOUN
admet-286	61	15	inoculum	inoculum	NOUN
admet-286	61	16	of	of	ADP
admet-286	61	17	108	108	NUM
admet-286	61	18	cfu	cfu	NOUN
admet-286	61	19	/	/	SYM
admet-286	61	20	ml	ml	NOUN
admet-286	61	21	in	in	ADP
admet-286	61	22	500	500	NUM
admet-286	61	23	ml	ml	NOUN
admet-286	61	24	central	central	ADJ
admet-286	61	25	reservoir	reservoir	NOUN
admet-286	61	26	flask	flask	NOUN
admet-286	61	27	containing	contain	VERB
admet-286	61	28	media	medium	NOUN
admet-286	61	29	.	.	PUNCT
admet-286	62	1	an	an	DET
admet-286	62	2	aqueous	aqueous	ADJ
admet-286	62	3	solution	solution	NOUN
admet-286	62	4	of	of	ADP
admet-286	62	5	fdc	fdc	PROPN
admet-286	62	6	was	be	AUX
admet-286	62	7	prepared	prepare	VERB
admet-286	62	8	.	.	PUNCT
admet-286	63	1	the	the	DET
admet-286	63	2	vishnu	vishnu	PROPN
admet-286	63	3	sharma	sharma	PROPN
admet-286	63	4	et	et	PROPN
admet-286	63	5	al	al	PROPN
admet-286	63	6	.	.	PROPN
admet-286	63	7	admet	admet	PROPN
admet-286	63	8	&	&	CCONJ
admet-286	63	9	dmpk	dmpk	PROPN
admet-286	63	10	4(3	4(3	NUM
admet-286	63	11	)	)	PUNCT
admet-286	63	12	(	(	PUNCT
admet-286	63	13	2016	2016	NUM
admet-286	63	14	)	)	PUNCT
admet-286	63	15	241	241	NUM
admet-286	63	16	-	-	SYM
admet-286	63	17	260	260	NUM
admet-286	63	18	244	244	NUM
admet-286	63	19	“	"	PUNCT
admet-286	63	20	in	in	ADP
admet-286	63	21	”	"	PUNCT
admet-286	63	22	and	and	CCONJ
admet-286	63	23	“	"	PUNCT
admet-286	63	24	out	out	ADJ
admet-286	63	25	”	"	PUNCT
admet-286	63	26	flow	flow	NOUN
admet-286	63	27	rates	rate	NOUN
admet-286	63	28	from	from	ADP
admet-286	63	29	the	the	DET
admet-286	63	30	central	central	ADJ
admet-286	63	31	reservoir	reservoir	NOUN
admet-286	63	32	were	be	AUX
admet-286	63	33	adjusted	adjust	VERB
admet-286	63	34	to	to	PART
admet-286	63	35	obtain	obtain	VERB
admet-286	63	36	half	half	ADJ
admet-286	63	37	-	-	PUNCT
admet-286	63	38	life	life	NOUN
admet-286	63	39	of	of	ADP
admet-286	63	40	~5	~5	NOUN
admet-286	63	41	-	-	SYM
admet-286	63	42	6	6	NUM
admet-286	63	43	h	h	NOUN
admet-286	64	1	[	[	X
admet-286	64	2	22	22	NUM
admet-286	64	3	-	-	SYM
admet-286	64	4	24	24	NUM
admet-286	64	5	]	]	PUNCT
admet-286	64	6	.	.	PUNCT
admet-286	65	1	samples	sample	NOUN
admet-286	65	2	from	from	ADP
admet-286	65	3	the	the	DET
admet-286	65	4	central	central	ADJ
admet-286	65	5	reservoir	reservoir	NOUN
admet-286	65	6	were	be	AUX
admet-286	65	7	collected	collect	VERB
admet-286	65	8	at	at	ADP
admet-286	65	9	different	different	ADJ
admet-286	65	10	time	time	NOUN
admet-286	65	11	points	point	NOUN
admet-286	65	12	from	from	ADP
admet-286	65	13	0	0	NUM
admet-286	65	14	to	to	ADP
admet-286	65	15	24	24	NUM
admet-286	65	16	h	h	NOUN
admet-286	65	17	post	post	ADJ
admet-286	65	18	-	-	ADJ
admet-286	65	19	fdc	fdc	ADJ
admet-286	65	20	addition	addition	NOUN
admet-286	65	21	.	.	PUNCT
admet-286	66	1	the	the	DET
admet-286	66	2	samples	sample	NOUN
admet-286	66	3	were	be	AUX
admet-286	66	4	analysed	analyse	VERB
admet-286	66	5	for	for	ADP
admet-286	66	6	individual	individual	ADJ
admet-286	66	7	component	component	NOUN
admet-286	66	8	concentrations	concentration	NOUN
admet-286	66	9	and	and	CCONJ
admet-286	66	10	cfu	cfu	NOUN
admet-286	66	11	determination	determination	NOUN
admet-286	66	12	for	for	ADP
admet-286	66	13	bacterial	bacterial	ADJ
admet-286	66	14	densities	density	NOUN
admet-286	66	15	.	.	PUNCT
admet-286	67	1	the	the	DET
admet-286	67	2	bacteria	bacteria	NOUN
admet-286	67	3	growth	growth	NOUN
admet-286	67	4	control	control	NOUN
admet-286	67	5	experiments	experiment	NOUN
admet-286	67	6	were	be	AUX
admet-286	67	7	also	also	ADV
admet-286	67	8	performed	perform	VERB
admet-286	67	9	using	use	VERB
admet-286	67	10	the	the	DET
admet-286	67	11	same	same	ADJ
admet-286	67	12	experimental	experimental	ADJ
admet-286	67	13	set	set	NOUN
admet-286	67	14	-	-	PUNCT
admet-286	67	15	up	up	NOUN
admet-286	67	16	without	without	ADP
admet-286	67	17	adding	add	VERB
admet-286	67	18	any	any	DET
admet-286	67	19	drug	drug	NOUN
admet-286	67	20	.	.	PUNCT
admet-286	68	1	net	net	ADJ
admet-286	68	2	pd	pd	PROPN
admet-286	68	3	effects	effect	NOUN
admet-286	68	4	of	of	ADP
admet-286	68	5	all	all	DET
admet-286	68	6	doses	dose	NOUN
admet-286	68	7	of	of	ADP
admet-286	68	8	fdc	fdc	PROPN
admet-286	68	9	were	be	AUX
admet-286	68	10	then	then	ADV
admet-286	68	11	reported	report	VERB
admet-286	68	12	after	after	ADP
admet-286	68	13	accounting	account	VERB
admet-286	68	14	the	the	DET
admet-286	68	15	bacterial	bacterial	ADJ
admet-286	68	16	dynamics	dynamic	NOUN
admet-286	68	17	of	of	ADP
admet-286	68	18	the	the	DET
admet-286	68	19	growth	growth	NOUN
admet-286	68	20	control	control	NOUN
admet-286	68	21	experiment	experiment	NOUN
admet-286	68	22	.	.	PUNCT
admet-286	69	1	pre	pre	VERB
admet-286	69	2	and	and	CCONJ
admet-286	69	3	post	post	VERB
admet-286	69	4	fdc	fdc	PROPN
admet-286	69	5	exposure	exposure	NOUN
admet-286	69	6	,	,	PUNCT
admet-286	69	7	mics	mic	NOUN
admet-286	69	8	were	be	AUX
admet-286	69	9	determined	determine	VERB
admet-286	69	10	for	for	ADP
admet-286	69	11	evaluating	evaluate	VERB
admet-286	69	12	any	any	DET
admet-286	69	13	changes	change	NOUN
admet-286	69	14	in	in	ADP
admet-286	69	15	mics	mic	NOUN
admet-286	69	16	due	due	ADP
admet-286	69	17	to	to	ADP
admet-286	69	18	fdc	fdc	PROPN
admet-286	69	19	exposure	exposure	NOUN
admet-286	69	20	.	.	PUNCT
admet-286	70	1	also	also	ADV
admet-286	70	2	the	the	DET
admet-286	70	3	pk	pk	NOUN
admet-286	70	4	parameters	parameter	NOUN
admet-286	70	5	calculated	calculate	VERB
admet-286	70	6	in	in	ADP
admet-286	70	7	in	in	ADP
admet-286	70	8	vitro	vitro	X
admet-286	70	9	chemostat	chemostat	NOUN
admet-286	70	10	infection	infection	NOUN
admet-286	70	11	model	model	NOUN
admet-286	70	12	for	for	ADP
admet-286	70	13	individual	individual	ADJ
admet-286	70	14	drugs	drug	NOUN
admet-286	70	15	were	be	AUX
admet-286	70	16	in	in	ADP
admet-286	70	17	concordance	concordance	NOUN
admet-286	70	18	with	with	ADP
admet-286	70	19	in	in	ADP
admet-286	70	20	vivo	vivo	ADJ
admet-286	70	21	literature	literature	NOUN
admet-286	70	22	values	value	NOUN
admet-286	70	23	(	(	PUNCT
admet-286	70	24	table	table	NOUN
admet-286	70	25	1	1	NUM
admet-286	70	26	)	)	PUNCT
admet-286	70	27	supporting	support	VERB
admet-286	70	28	the	the	DET
admet-286	70	29	validity	validity	NOUN
admet-286	70	30	of	of	ADP
admet-286	70	31	in	in	ADP
admet-286	70	32	vitro	vitro	X
admet-286	70	33	systems	system	NOUN
admet-286	70	34	.	.	PUNCT
admet-286	71	1	dose	dose	NOUN
admet-286	71	2	escalation	escalation	NOUN
admet-286	71	3	,	,	PUNCT
admet-286	71	4	fractionation	fractionation	NOUN
admet-286	71	5	and	and	CCONJ
admet-286	71	6	response	response	NOUN
admet-286	71	7	curve	curve	NOUN
admet-286	71	8	studies	study	NOUN
admet-286	71	9	using	use	VERB
admet-286	71	10	in	in	ADP
admet-286	71	11	vitro	vitro	X
admet-286	71	12	chemostat	chemostat	NOUN
admet-286	71	13	model	model	NOUN
admet-286	71	14	the	the	DET
admet-286	71	15	drug	drug	NOUN
admet-286	71	16	concentrations	concentration	NOUN
admet-286	71	17	were	be	AUX
admet-286	71	18	varied	varied	ADJ
admet-286	71	19	from	from	ADP
admet-286	71	20	0.5	0.5	NUM
admet-286	71	21	-	-	SYM
admet-286	71	22	200	200	NUM
admet-286	71	23	folds	fold	NOUN
admet-286	71	24	mics	mic	NOUN
admet-286	71	25	to	to	PART
admet-286	71	26	determine	determine	VERB
admet-286	71	27	the	the	DET
admet-286	71	28	most	most	ADV
admet-286	71	29	efficacious	efficacious	ADJ
admet-286	71	30	exposure	exposure	NOUN
admet-286	71	31	based	base	VERB
admet-286	71	32	on	on	ADP
admet-286	71	33	their	their	PRON
admet-286	71	34	pk	pk	NOUN
admet-286	71	35	/	/	SYM
admet-286	71	36	pd	pd	NOUN
admet-286	71	37	parameters	parameter	NOUN
admet-286	71	38	.	.	PUNCT
admet-286	72	1	the	the	DET
admet-286	72	2	best	good	ADJ
admet-286	72	3	exposure	exposure	NOUN
admet-286	72	4	from	from	ADP
admet-286	72	5	dose	dose	NOUN
admet-286	72	6	escalation	escalation	NOUN
admet-286	72	7	study	study	NOUN
admet-286	72	8	was	be	AUX
admet-286	72	9	then	then	ADV
admet-286	72	10	fractionated	fractionate	VERB
admet-286	72	11	twice	twice	ADV
admet-286	72	12	-	-	PUNCT
admet-286	72	13	a	a	DET
admet-286	72	14	-	-	PUNCT
admet-286	72	15	day	day	NOUN
admet-286	72	16	and	and	CCONJ
admet-286	72	17	thrice	thrice	NOUN
admet-286	72	18	-	-	PUNCT
admet-286	72	19	a	a	DET
admet-286	72	20	-	-	PUNCT
admet-286	72	21	day	day	NOUN
admet-286	72	22	to	to	PART
admet-286	72	23	determine	determine	VERB
admet-286	72	24	a	a	DET
admet-286	72	25	dosage	dosage	NOUN
admet-286	72	26	regimen	regiman	NOUN
admet-286	72	27	of	of	ADP
admet-286	72	28	antibiotic	antibiotic	NOUN
admet-286	72	29	which	which	PRON
admet-286	72	30	can	can	AUX
admet-286	72	31	enhance	enhance	VERB
admet-286	72	32	bacterial	bacterial	ADJ
admet-286	72	33	killing	killing	NOUN
admet-286	72	34	at	at	ADP
admet-286	72	35	lower	low	ADJ
admet-286	72	36	concentration	concentration	NOUN
admet-286	72	37	.	.	PUNCT
admet-286	73	1	the	the	DET
admet-286	73	2	best	good	ADJ
admet-286	73	3	dosage	dosage	NOUN
admet-286	73	4	regimen	regiman	NOUN
admet-286	73	5	was	be	AUX
admet-286	73	6	then	then	ADV
admet-286	73	7	used	use	VERB
admet-286	73	8	to	to	PART
admet-286	73	9	construct	construct	VERB
admet-286	73	10	dose	dose	NOUN
admet-286	73	11	response	response	NOUN
admet-286	73	12	curve	curve	NOUN
admet-286	73	13	.	.	PUNCT
admet-286	74	1	the	the	DET
admet-286	74	2	dosage	dosage	NOUN
admet-286	74	3	regimen	regiman	NOUN
admet-286	74	4	at	at	ADP
admet-286	74	5	75	75	NUM
admet-286	74	6	,	,	PUNCT
admet-286	74	7	50	50	NUM
admet-286	74	8	,	,	PUNCT
admet-286	74	9	38	38	NUM
admet-286	74	10	,	,	PUNCT
admet-286	74	11	and	and	CCONJ
admet-286	74	12	25	25	NUM
admet-286	74	13	%	%	NOUN
admet-286	74	14	of	of	ADP
admet-286	74	15	original	original	ADJ
admet-286	74	16	concentration	concentration	NOUN
admet-286	74	17	were	be	AUX
admet-286	74	18	utilized	utilize	VERB
admet-286	74	19	and	and	CCONJ
admet-286	74	20	the	the	DET
admet-286	74	21	corresponding	corresponding	ADJ
admet-286	74	22	change	change	NOUN
admet-286	74	23	in	in	ADP
admet-286	74	24	bacterial	bacterial	ADJ
admet-286	74	25	density	density	NOUN
admet-286	74	26	in	in	ADP
admet-286	74	27	24	24	NUM
admet-286	74	28	h	h	NOUN
admet-286	74	29	was	be	AUX
admet-286	74	30	measured	measure	VERB
admet-286	74	31	.	.	PUNCT
admet-286	75	1	the	the	DET
admet-286	75	2	dose	dose	PROPN
admet-286	75	3	response	response	NOUN
admet-286	75	4	curve	curve	NOUN
admet-286	75	5	was	be	AUX
admet-286	75	6	plotted	plot	VERB
admet-286	75	7	between	between	ADP
admet-286	75	8	the	the	DET
admet-286	75	9	dose	dose	NOUN
admet-286	75	10	percentage	percentage	NOUN
admet-286	75	11	and	and	CCONJ
admet-286	75	12	log	log	NOUN
admet-286	75	13	reduction	reduction	NOUN
admet-286	75	14	in	in	ADP
admet-286	75	15	bacterial	bacterial	ADJ
admet-286	75	16	density	density	NOUN
admet-286	75	17	and	and	CCONJ
admet-286	75	18	ec50	ec50	PROPN
admet-286	75	19	was	be	AUX
admet-286	75	20	calculated	calculate	VERB
admet-286	75	21	.	.	PUNCT
admet-286	76	1	pharmacokinetic	pharmacokinetic	ADJ
admet-286	76	2	analysis	analysis	NOUN
admet-286	76	3	one	one	NUM
admet-286	76	4	compartment	compartment	NOUN
admet-286	76	5	model	model	NOUN
admet-286	76	6	was	be	AUX
admet-286	76	7	used	use	VERB
admet-286	76	8	to	to	PART
admet-286	76	9	fit	fit	VERB
admet-286	76	10	the	the	DET
admet-286	76	11	time	time	NOUN
admet-286	76	12	concentration	concentration	NOUN
admet-286	76	13	values	value	NOUN
admet-286	76	14	and	and	CCONJ
admet-286	76	15	pk	pk	NOUN
admet-286	76	16	parameters	parameter	NOUN
admet-286	76	17	of	of	ADP
admet-286	76	18	ceftriaxone	ceftriaxone	PROPN
admet-286	76	19	and	and	CCONJ
admet-286	76	20	vancomycin	vancomycin	PROPN
admet-286	76	21	were	be	AUX
admet-286	76	22	calculated	calculate	VERB
admet-286	76	23	.	.	PUNCT
admet-286	77	1	the	the	DET
admet-286	77	2	parameters	parameter	NOUN
admet-286	77	3	included	include	VERB
admet-286	77	4	the	the	DET
admet-286	77	5	area	area	NOUN
admet-286	77	6	under	under	ADP
admet-286	77	7	the	the	DET
admet-286	77	8	plasma	plasma	NOUN
admet-286	77	9	concentration	concentration	NOUN
admet-286	77	10	-	-	PUNCT
admet-286	77	11	time	time	NOUN
admet-286	77	12	curve	curve	NOUN
admet-286	77	13	(	(	PUNCT
admet-286	77	14	auc	auc	NOUN
admet-286	77	15	)	)	PUNCT
admet-286	77	16	,	,	PUNCT
admet-286	77	17	maximal	maximal	ADJ
admet-286	77	18	concentration	concentration	NOUN
admet-286	77	19	reached	reach	VERB
admet-286	77	20	(	(	PUNCT
admet-286	77	21	the	the	DET
admet-286	77	22	peak	peak	NOUN
admet-286	77	23	;	;	PUNCT
admet-286	77	24	cmax	cmax	NOUN
admet-286	77	25	)	)	PUNCT
admet-286	77	26	,	,	PUNCT
admet-286	77	27	elimination	elimination	NOUN
admet-286	77	28	rate	rate	NOUN
admet-286	77	29	constant	constant	ADJ
admet-286	77	30	(	(	PUNCT
admet-286	77	31	ke	ke	NOUN
admet-286	77	32	)	)	PUNCT
admet-286	77	33	,	,	PUNCT
admet-286	77	34	half	half	ADJ
admet-286	77	35	-	-	PUNCT
admet-286	77	36	life	life	NOUN
admet-286	77	37	(	(	PUNCT
admet-286	77	38	t1/2	t1/2	NOUN
admet-286	77	39	)	)	PUNCT
admet-286	77	40	,	,	PUNCT
admet-286	77	41	volume	volume	NOUN
admet-286	77	42	of	of	ADP
admet-286	77	43	distribution	distribution	NOUN
admet-286	77	44	(	(	PUNCT
admet-286	77	45	vd	vd	NOUN
admet-286	77	46	)	)	PUNCT
admet-286	77	47	,	,	PUNCT
admet-286	77	48	and	and	CCONJ
admet-286	77	49	clearance	clearance	NOUN
admet-286	77	50	(	(	PUNCT
admet-286	77	51	cl	cl	NOUN
admet-286	77	52	)	)	PUNCT
admet-286	77	53	.	.	PUNCT
admet-286	78	1	these	these	DET
admet-286	78	2	parameters	parameter	NOUN
admet-286	78	3	were	be	AUX
admet-286	78	4	calculated	calculate	VERB
admet-286	78	5	for	for	ADP
admet-286	78	6	all	all	DET
admet-286	78	7	dose	dose	NOUN
admet-286	78	8	escalations	escalation	NOUN
admet-286	78	9	and	and	CCONJ
admet-286	78	10	dose	dose	NOUN
admet-286	78	11	fractionation	fractionation	NOUN
admet-286	78	12	studies	study	NOUN
admet-286	78	13	.	.	PUNCT
admet-286	79	1	the	the	DET
admet-286	79	2	parameters	parameter	NOUN
admet-286	79	3	obtained	obtain	VERB
admet-286	79	4	from	from	ADP
admet-286	79	5	concentration	concentration	NOUN
admet-286	79	6	profile	profile	NOUN
admet-286	79	7	data	datum	NOUN
admet-286	79	8	were	be	AUX
admet-286	79	9	compared	compare	VERB
admet-286	79	10	with	with	ADP
admet-286	79	11	reported	report	VERB
admet-286	79	12	population	population	NOUN
admet-286	79	13	pk	pk	NOUN
admet-286	79	14	parameters	parameter	NOUN
admet-286	79	15	in	in	ADP
admet-286	79	16	the	the	DET
admet-286	79	17	literature	literature	NOUN
admet-286	79	18	(	(	PUNCT
admet-286	79	19	table	table	NOUN
admet-286	79	20	1	1	NUM
admet-286	79	21	)	)	PUNCT
admet-286	79	22	.	.	PUNCT
admet-286	80	1	pharmacokinetic	pharmacokinetic	ADJ
admet-286	80	2	/	/	SYM
admet-286	80	3	pharmacodynamic	pharmacodynamic	ADJ
admet-286	80	4	analysis	analysis	NOUN
admet-286	80	5	the	the	DET
admet-286	80	6	fic	fic	ADJ
admet-286	80	7	curves	curve	NOUN
admet-286	80	8	for	for	ADP
admet-286	80	9	ceftriaxone	ceftriaxone	NOUN
admet-286	80	10	and	and	CCONJ
admet-286	80	11	vancomycin	vancomycin	PROPN
admet-286	80	12	combinations	combination	NOUN
admet-286	80	13	were	be	AUX
admet-286	80	14	generated	generate	VERB
admet-286	80	15	.	.	PUNCT
admet-286	81	1	briefly	briefly	ADV
admet-286	81	2	,	,	PUNCT
admet-286	81	3	the	the	DET
admet-286	81	4	concentrations	concentration	NOUN
admet-286	81	5	of	of	ADP
admet-286	81	6	each	each	DET
admet-286	81	7	antibiotic	antibiotic	NOUN
admet-286	81	8	at	at	ADP
admet-286	81	9	every	every	DET
admet-286	81	10	time	time	NOUN
admet-286	81	11	-	-	PUNCT
admet-286	81	12	point	point	NOUN
admet-286	81	13	were	be	AUX
admet-286	81	14	divided	divide	VERB
admet-286	81	15	by	by	ADP
admet-286	81	16	their	their	PRON
admet-286	81	17	respective	respective	ADJ
admet-286	81	18	mic	mic	ADJ
admet-286	81	19	contributions	contribution	NOUN
admet-286	81	20	towards	towards	ADP
admet-286	81	21	miccomb	miccomb	NOUN
admet-286	81	22	to	to	PART
admet-286	81	23	obtain	obtain	VERB
admet-286	81	24	ficceftriaxone	ficceftriaxone	NOUN
admet-286	81	25	and	and	CCONJ
admet-286	81	26	ficvancomycin	ficvancomycin	PROPN
admet-286	81	27	values	value	NOUN
admet-286	81	28	.	.	PUNCT
admet-286	82	1	these	these	DET
admet-286	82	2	values	value	NOUN
admet-286	82	3	were	be	AUX
admet-286	82	4	added	add	VERB
admet-286	82	5	(	(	PUNCT
admet-286	82	6	ficcomb	ficcomb	NOUN
admet-286	82	7	)	)	PUNCT
admet-286	82	8	for	for	ADP
admet-286	82	9	each	each	DET
admet-286	82	10	time	time	NOUN
admet-286	82	11	points	point	NOUN
admet-286	82	12	and	and	CCONJ
admet-286	82	13	plotted	plot	VERB
admet-286	82	14	against	against	ADP
admet-286	82	15	time	time	NOUN
admet-286	82	16	.	.	PUNCT
admet-286	83	1	the	the	DET
admet-286	83	2	resultant	resultant	ADJ
admet-286	83	3	fic	fic	ADJ
admet-286	83	4	-	-	PUNCT
admet-286	83	5	time	time	NOUN
admet-286	83	6	profile	profile	NOUN
admet-286	83	7	was	be	AUX
admet-286	83	8	fitted	fit	VERB
admet-286	83	9	to	to	ADP
admet-286	83	10	one	one	NUM
admet-286	83	11	compartment	compartment	NOUN
admet-286	83	12	model	model	NOUN
admet-286	83	13	to	to	PART
admet-286	83	14	obtain	obtain	VERB
admet-286	83	15	pk	pk	NOUN
admet-286	83	16	/	/	SYM
admet-286	83	17	pd	pd	NOUN
admet-286	83	18	parameters	parameter	NOUN
admet-286	83	19	i.e.	i.e.	X
admet-286	83	20	auccomb	auccomb	NOUN
admet-286	83	21	,	,	PUNCT
admet-286	83	22	cmax	cmax	NOUN
admet-286	83	23	-	-	PUNCT
admet-286	83	24	comb	comb	NOUN
admet-286	83	25	,	,	PUNCT
admet-286	83	26	%	%	INTJ
admet-286	83	27	t	t	X
admet-286	83	28	>	>	X
admet-286	83	29	miccomb	miccomb	PROPN
admet-286	84	1	and	and	CCONJ
admet-286	84	2	%	%	INTJ
admet-286	84	3	t	t	X
admet-286	84	4	>	>	X
admet-286	84	5	ficcomb	ficcomb	NOUN
admet-286	85	1	[	[	X
admet-286	85	2	9,16	9,16	NUM
admet-286	85	3	]	]	PUNCT
admet-286	85	4	.	.	PUNCT
admet-286	86	1	in	in	ADP
admet-286	86	2	addition	addition	NOUN
admet-286	86	3	,	,	PUNCT
admet-286	86	4	the	the	DET
admet-286	86	5	pk	pk	PROPN
admet-286	86	6	/	/	SYM
admet-286	86	7	pd	pd	PROPN
admet-286	86	8	indices	index	NOUN
admet-286	86	9	i.e.	i.e.	X
admet-286	86	10	auc	auc	NOUN
admet-286	86	11	/	/	SYM
admet-286	86	12	mic	mic	ADJ
admet-286	86	13	,	,	PUNCT
admet-286	86	14	cmax	cmax	NOUN
admet-286	86	15	/	/	SYM
admet-286	86	16	mic	mic	ADJ
admet-286	86	17	and	and	CCONJ
admet-286	86	18	%	%	NOUN
admet-286	86	19	t	t	PROPN
admet-286	86	20	>	>	X
admet-286	86	21	mic	mic	NOUN
admet-286	86	22	were	be	AUX
admet-286	86	23	also	also	ADV
admet-286	86	24	calculated	calculate	VERB
admet-286	86	25	for	for	ADP
admet-286	86	26	both	both	CCONJ
admet-286	86	27	ceftriaxone	ceftriaxone	NOUN
admet-286	86	28	and	and	CCONJ
admet-286	86	29	vancomycin	vancomycin	PROPN
admet-286	86	30	using	use	VERB
admet-286	86	31	their	their	PRON
admet-286	86	32	respective	respective	ADJ
admet-286	86	33	pk	pk	NOUN
admet-286	86	34	parameters	parameter	NOUN
admet-286	86	35	.	.	PUNCT
admet-286	87	1	admet	admet	PROPN
admet-286	87	2	&	&	CCONJ
admet-286	87	3	dmpk	dmpk	PROPN
admet-286	87	4	4(3	4(3	NUM
admet-286	87	5	)	)	PUNCT
admet-286	87	6	(	(	PUNCT
admet-286	87	7	2016	2016	NUM
admet-286	87	8	)	)	PUNCT
admet-286	87	9	241	241	NUM
admet-286	87	10	-	-	SYM
admet-286	87	11	260	260	NUM
admet-286	87	12	dose	dose	NOUN
admet-286	87	13	optimization	optimization	NOUN
admet-286	87	14	of	of	ADP
admet-286	87	15	fdc	fdc	PROPN
admet-286	87	16	against	against	ADP
admet-286	87	17	s.	s.	PROPN
admet-286	87	18	aureus	aureus	PROPN
admet-286	87	19	resistant	resistant	ADJ
admet-286	87	20	bacteria	bacteria	NOUN
admet-286	87	21	doi	doi	NOUN
admet-286	87	22	:	:	PUNCT
admet-286	87	23	10.5599	10.5599	NUM
admet-286	87	24	/	/	SYM
admet-286	87	25	admet.4.3.286	admet.4.3.286	ADJ
admet-286	87	26	245	245	NUM
admet-286	87	27	figure	figure	NOUN
admet-286	87	28	2	2	NUM
admet-286	87	29	.	.	PUNCT
admet-286	88	1	the	the	DET
admet-286	88	2	inter	inter	NOUN
admet-286	88	3	-	-	NOUN
admet-286	88	4	relationship	relationship	NOUN
admet-286	88	5	between	between	ADP
admet-286	88	6	the	the	DET
admet-286	88	7	time	time	NOUN
admet-286	88	8	dependent	dependent	ADJ
admet-286	88	9	changes	change	NOUN
admet-286	88	10	in	in	ADP
admet-286	88	11	drug	drug	NOUN
admet-286	88	12	concentrations	concentration	NOUN
admet-286	88	13	(	(	PUNCT
admet-286	88	14	pk	pk	NOUN
admet-286	88	15	-	-	PUNCT
admet-286	88	16	intravenous	intravenous	ADJ
admet-286	88	17	(	(	PUNCT
admet-286	88	18	iv	iv	NOUN
admet-286	88	19	)	)	PUNCT
admet-286	88	20	infusion	infusion	NOUN
admet-286	88	21	)	)	PUNCT
admet-286	88	22	and	and	CCONJ
admet-286	88	23	the	the	DET
admet-286	88	24	bacterial	bacterial	ADJ
admet-286	88	25	growth	growth	NOUN
admet-286	88	26	inhibition	inhibition	NOUN
admet-286	88	27	/	/	SYM
admet-286	88	28	bacterial	bacterial	ADJ
admet-286	88	29	killing	killing	NOUN
admet-286	88	30	(	(	PUNCT
admet-286	88	31	pd	pd	NOUN
admet-286	88	32	)	)	PUNCT
admet-286	88	33	after	after	ADP
admet-286	88	34	antibacterial	antibacterial	ADJ
admet-286	88	35	treatment	treatment	NOUN
admet-286	88	36	.	.	PUNCT
admet-286	89	1	the	the	DET
admet-286	89	2	parameters	parameter	NOUN
admet-286	89	3	are	be	AUX
admet-286	89	4	c	c	NOUN
admet-286	89	5	,	,	PUNCT
admet-286	89	6	the	the	DET
admet-286	89	7	concentration	concentration	NOUN
admet-286	89	8	of	of	ADP
admet-286	89	9	combination	combination	NOUN
admet-286	89	10	or	or	CCONJ
admet-286	89	11	individual	individual	ADJ
admet-286	89	12	component	component	NOUN
admet-286	89	13	of	of	ADP
admet-286	89	14	fdc	fdc	PROPN
admet-286	89	15	in	in	ADP
admet-286	89	16	central	central	ADJ
admet-286	89	17	drug	drug	NOUN
admet-286	89	18	compartment	compartment	NOUN
admet-286	89	19	;	;	PUNCT
admet-286	89	20	ke	ke	NOUN
admet-286	89	21	,	,	PUNCT
admet-286	89	22	drug	drug	NOUN
admet-286	89	23	elimination	elimination	NOUN
admet-286	89	24	rate	rate	NOUN
admet-286	89	25	constant	constant	ADJ
admet-286	89	26	;	;	PUNCT
admet-286	89	27	kgrowth	kgrowth	NOUN
admet-286	89	28	and	and	CCONJ
admet-286	89	29	kdeath	kdeath	NOUN
admet-286	89	30	,	,	PUNCT
admet-286	89	31	rate	rate	NOUN
admet-286	89	32	constants	constant	NOUN
admet-286	89	33	for	for	ADP
admet-286	89	34	multiplication	multiplication	NOUN
admet-286	89	35	and	and	CCONJ
admet-286	89	36	degradation	degradation	NOUN
admet-286	89	37	of	of	ADP
admet-286	89	38	bacteria	bacteria	NOUN
admet-286	89	39	,	,	PUNCT
admet-286	89	40	respectively	respectively	ADV
admet-286	89	41	and	and	CCONJ
admet-286	89	42	b	b	NOUN
admet-286	89	43	is	be	AUX
admet-286	89	44	bacterial	bacterial	ADJ
admet-286	89	45	load	load	NOUN
admet-286	89	46	at	at	ADP
admet-286	89	47	a	a	DET
admet-286	89	48	given	give	VERB
admet-286	89	49	time	time	NOUN
admet-286	89	50	point	point	NOUN
admet-286	89	51	.	.	PUNCT
admet-286	90	1	semi	semi	ADJ
admet-286	90	2	-	-	ADJ
admet-286	90	3	mechanistic	mechanistic	ADJ
admet-286	90	4	pharmacokinetic	pharmacokinetic	ADJ
admet-286	90	5	/	/	SYM
admet-286	90	6	pharmacodynamic	pharmacodynamic	ADJ
admet-286	90	7	modeling	modeling	NOUN
admet-286	90	8	and	and	CCONJ
admet-286	90	9	validation	validation	NOUN
admet-286	90	10	bacterial	bacterial	ADJ
admet-286	90	11	modeling	modeling	NOUN
admet-286	90	12	(	(	PUNCT
admet-286	90	13	control	control	NOUN
admet-286	90	14	experiments	experiment	NOUN
admet-286	90	15	):	):	PUNCT
admet-286	90	16	the	the	DET
admet-286	90	17	bacterial	bacterial	ADJ
admet-286	90	18	kinetics	kinetic	NOUN
admet-286	90	19	determination	determination	NOUN
admet-286	90	20	involves	involve	VERB
admet-286	90	21	modeling	modeling	NOUN
admet-286	90	22	of	of	ADP
admet-286	90	23	a	a	DET
admet-286	90	24	single	single	ADJ
admet-286	90	25	bacterial	bacterial	ADJ
admet-286	90	26	compartment	compartment	NOUN
admet-286	90	27	(	(	PUNCT
admet-286	90	28	b	b	NOUN
admet-286	90	29	)	)	PUNCT
admet-286	90	30	with	with	ADP
admet-286	90	31	first	first	ADJ
admet-286	90	32	-	-	PUNCT
admet-286	90	33	order	order	NOUN
admet-286	90	34	rate	rate	NOUN
admet-286	90	35	constants	constant	NOUN
admet-286	90	36	for	for	ADP
admet-286	90	37	bacterial	bacterial	ADJ
admet-286	90	38	multiplication	multiplication	NOUN
admet-286	90	39	(	(	PUNCT
admet-286	90	40	kgrowth	kgrowth	NOUN
admet-286	90	41	)	)	PUNCT
admet-286	90	42	and	and	CCONJ
admet-286	90	43	bacterial	bacterial	ADJ
admet-286	90	44	death	death	NOUN
admet-286	90	45	(	(	PUNCT
admet-286	90	46	kdeath	kdeath	NOUN
admet-286	90	47	)	)	PUNCT
admet-286	91	1	[	[	X
admet-286	91	2	25	25	NUM
admet-286	91	3	]	]	PUNCT
admet-286	91	4	.	.	PUNCT
admet-286	92	1	the	the	DET
admet-286	92	2	equation	equation	NOUN
admet-286	92	3	1	1	NUM
admet-286	92	4	explains	explain	VERB
admet-286	92	5	the	the	DET
admet-286	92	6	observed	observed	ADJ
admet-286	92	7	exponential	exponential	ADJ
admet-286	92	8	growth	growth	NOUN
admet-286	92	9	of	of	ADP
admet-286	92	10	bacteria	bacteria	NOUN
admet-286	92	11	until	until	SCONJ
admet-286	92	12	it	it	PRON
admet-286	92	13	reaches	reach	VERB
admet-286	92	14	a	a	DET
admet-286	92	15	stationary	stationary	ADJ
admet-286	92	16	bacterial	bacterial	ADJ
admet-286	92	17	level	level	NOUN
admet-286	92	18	without	without	ADP
admet-286	92	19	the	the	DET
admet-286	92	20	addition	addition	NOUN
admet-286	92	21	of	of	ADP
admet-286	92	22	antibiotics	antibiotic	NOUN
admet-286	92	23	(	(	PUNCT
admet-286	92	24	control	control	NOUN
admet-286	92	25	experiments	experiment	NOUN
admet-286	92	26	)	)	PUNCT
admet-286	92	27	and	and	CCONJ
admet-286	92	28	where	where	SCONJ
admet-286	92	29	b	b	NOUN
admet-286	92	30	and	and	CCONJ
admet-286	92	31	bmax	bmax	NOUN
admet-286	92	32	are	be	AUX
admet-286	92	33	initial	initial	ADJ
admet-286	92	34	bacterial	bacterial	ADJ
admet-286	92	35	density	density	NOUN
admet-286	92	36	and	and	CCONJ
admet-286	92	37	maximum	maximum	ADJ
admet-286	92	38	bacterial	bacterial	ADJ
admet-286	92	39	density	density	NOUN
admet-286	92	40	[	[	X
admet-286	92	41	26	26	NUM
admet-286	92	42	]	]	PUNCT
admet-286	92	43	.	.	PUNCT
admet-286	93	1	(	(	PUNCT
admet-286	93	2	1	1	X
admet-286	93	3	)	)	PUNCT
admet-286	93	4	pharmacokinetic	pharmacokinetic	ADJ
admet-286	93	5	/	/	SYM
admet-286	93	6	pharmacodynamic	pharmacodynamic	ADJ
admet-286	93	7	modeling	modeling	NOUN
admet-286	93	8	:	:	PUNCT
admet-286	93	9	the	the	DET
admet-286	93	10	bacterial	bacterial	ADJ
admet-286	93	11	load	load	NOUN
admet-286	93	12	was	be	AUX
admet-286	93	13	evaluated	evaluate	VERB
admet-286	93	14	at	at	ADP
admet-286	93	15	8	8	NUM
admet-286	93	16	,	,	PUNCT
admet-286	93	17	9.5	9.5	NUM
admet-286	93	18	,	,	PUNCT
admet-286	93	19	12	12	NUM
admet-286	93	20	and	and	CCONJ
admet-286	93	21	24	24	NUM
admet-286	93	22	h	h	NOUN
admet-286	93	23	post	post	VERB
admet-286	93	24	antibiotic	antibiotic	ADJ
admet-286	93	25	exposures	exposure	NOUN
admet-286	93	26	.	.	PUNCT
admet-286	94	1	the	the	DET
admet-286	94	2	8	8	NUM
admet-286	94	3	,	,	PUNCT
admet-286	94	4	12	12	NUM
admet-286	94	5	and	and	CCONJ
admet-286	94	6	24	24	NUM
admet-286	94	7	time	time	NOUN
admet-286	94	8	-	-	PUNCT
admet-286	94	9	points	point	NOUN
admet-286	94	10	were	be	AUX
admet-286	94	11	selected	select	VERB
admet-286	94	12	to	to	PART
admet-286	94	13	evaluate	evaluate	VERB
admet-286	94	14	bacterial	bacterial	ADJ
admet-286	94	15	load	load	NOUN
admet-286	94	16	in	in	ADP
admet-286	94	17	case	case	NOUN
admet-286	94	18	of	of	ADP
admet-286	94	19	thrice	thrice	NOUN
admet-286	94	20	-	-	PUNCT
admet-286	94	21	a	a	DET
admet-286	94	22	-	-	PUNCT
admet-286	94	23	day	day	NOUN
admet-286	94	24	,	,	PUNCT
admet-286	94	25	twice	twice	DET
admet-286	94	26	-	-	PUNCT
admet-286	94	27	a	a	DET
admet-286	94	28	-	-	PUNCT
admet-286	94	29	day	day	NOUN
admet-286	94	30	and	and	CCONJ
admet-286	94	31	once	once	ADV
admet-286	94	32	-	-	PUNCT
admet-286	94	33	a	a	DET
admet-286	94	34	-	-	PUNCT
admet-286	94	35	day	day	NOUN
admet-286	94	36	dose	dose	NOUN
admet-286	94	37	regimens	regimen	NOUN
admet-286	94	38	respectively	respectively	ADV
admet-286	94	39	;	;	PUNCT
admet-286	94	40	whereas	whereas	SCONJ
admet-286	94	41	,	,	PUNCT
admet-286	94	42	9.5	9.5	NUM
admet-286	94	43	h	h	NOUN
admet-286	94	44	time	time	NOUN
admet-286	94	45	-	-	PUNCT
admet-286	94	46	point	point	NOUN
admet-286	94	47	was	be	AUX
admet-286	94	48	selected	select	VERB
admet-286	94	49	for	for	ADP
admet-286	94	50	internal	internal	ADJ
admet-286	94	51	evaluation	evaluation	NOUN
admet-286	94	52	as	as	SCONJ
admet-286	94	53	the	the	DET
admet-286	94	54	second	second	ADJ
admet-286	94	55	inoculum	inoculum	NOUN
admet-286	94	56	was	be	AUX
admet-286	94	57	added	add	VERB
admet-286	94	58	to	to	ADP
admet-286	94	59	in	in	ADP
admet-286	94	60	vitro	vitro	X
admet-286	94	61	system	system	NOUN
admet-286	94	62	at	at	ADP
admet-286	94	63	9.5	9.5	NUM
admet-286	94	64	h	h	NOUN
admet-286	94	65	to	to	PART
admet-286	94	66	mimic	mimic	VERB
admet-286	94	67	harsher	harsh	ADJ
admet-286	94	68	in	in	ADP
admet-286	94	69	vivo	vivo	ADJ
admet-286	94	70	conditions	condition	NOUN
admet-286	94	71	.	.	PUNCT
admet-286	95	1	the	the	DET
admet-286	95	2	relationship	relationship	NOUN
admet-286	95	3	between	between	ADP
admet-286	95	4	the	the	DET
admet-286	95	5	effect	effect	NOUN
admet-286	95	6	and	and	CCONJ
admet-286	95	7	the	the	DET
admet-286	95	8	corresponding	corresponding	ADJ
admet-286	95	9	pk	pk	PROPN
admet-286	95	10	/	/	SYM
admet-286	95	11	pd	pd	PROPN
admet-286	95	12	indices	index	NOUN
admet-286	95	13	was	be	AUX
admet-286	95	14	evaluated	evaluate	VERB
admet-286	95	15	according	accord	VERB
admet-286	95	16	to	to	ADP
admet-286	95	17	a	a	DET
admet-286	95	18	sigmoidal	sigmoidal	NOUN
admet-286	95	19	emax	emax	NOUN
admet-286	95	20	type	type	NOUN
admet-286	95	21	function	function	NOUN
admet-286	95	22	as	as	SCONJ
admet-286	95	23	described	describe	VERB
admet-286	95	24	in	in	ADP
admet-286	95	25	equation	equation	NOUN
admet-286	95	26	2	2	NUM
admet-286	96	1	[	[	X
admet-286	96	2	9,6	9,6	NUM
admet-286	96	3	]	]	PUNCT
admet-286	96	4	.	.	PUNCT
admet-286	97	1	the	the	DET
admet-286	97	2	emax	emax	PROPN
admet-286	97	3	model	model	NOUN
admet-286	97	4	describes	describe	VERB
admet-286	97	5	the	the	DET
admet-286	97	6	concentration	concentration	NOUN
admet-286	97	7	–	–	PUNCT
admet-286	97	8	effect	effect	NOUN
admet-286	97	9	relationship	relationship	NOUN
admet-286	97	10	in	in	ADP
admet-286	97	11	terms	term	NOUN
admet-286	97	12	of	of	ADP
admet-286	97	13	a	a	DET
admet-286	97	14	baseline	baseline	ADJ
admet-286	97	15	effect	effect	NOUN
admet-286	97	16	or	or	CCONJ
admet-286	97	17	e0	e0	NOUN
admet-286	97	18	,	,	PUNCT
admet-286	97	19	hence	hence	ADV
admet-286	97	20	taking	take	VERB
admet-286	97	21	into	into	ADP
admet-286	97	22	account	account	NOUN
admet-286	97	23	the	the	DET
admet-286	97	24	baseline	baseline	NOUN
admet-286	97	25	condition	condition	NOUN
admet-286	97	26	which	which	PRON
admet-286	97	27	can	can	AUX
admet-286	97	28	significantly	significantly	ADV
admet-286	97	29	affect	affect	VERB
admet-286	97	30	the	the	DET
admet-286	97	31	maximum	maximum	ADJ
admet-286	97	32	activity	activity	NOUN
admet-286	97	33	of	of	ADP
admet-286	97	34	antibiotic	antibiotic	ADJ
admet-286	97	35	i.e.	i.e.	X
admet-286	97	36	pdmax	pdmax	ADJ
admet-286	97	37	,	,	PUNCT
admet-286	97	38	a	a	DET
admet-286	97	39	descriptor	descriptor	NOUN
admet-286	97	40	of	of	ADP
admet-286	97	41	direct	direct	ADJ
admet-286	97	42	response	response	NOUN
admet-286	97	43	of	of	ADP
admet-286	97	44	antibiotic	antibiotic	NOUN
admet-286	97	45	.	.	PUNCT
admet-286	98	1	additionally	additionally	ADV
admet-286	98	2	,	,	PUNCT
admet-286	98	3	the	the	DET
admet-286	98	4	function	function	NOUN
admet-286	98	5	asymptotes	asymptote	VERB
admet-286	98	6	to	to	ADP
admet-286	98	7	an	an	DET
admet-286	98	8	upper	upper	ADJ
admet-286	98	9	limit	limit	NOUN
admet-286	98	10	of	of	ADP
admet-286	98	11	inhibition	inhibition	NOUN
admet-286	98	12	by	by	ADP
admet-286	98	13	an	an	DET
admet-286	98	14	antibiotic	antibiotic	NOUN
admet-286	98	15	on	on	ADP
admet-286	98	16	bacterial	bacterial	ADJ
admet-286	98	17	load	load	NOUN
admet-286	98	18	.	.	PUNCT
admet-286	99	1	(	(	PUNCT
admet-286	99	2	2	2	NUM
admet-286	99	3	)	)	PUNCT
admet-286	99	4	where	where	SCONJ
admet-286	99	5	,	,	PUNCT
admet-286	99	6	e	e	X
admet-286	99	7	is	be	AUX
admet-286	99	8	the	the	DET
admet-286	99	9	pd	pd	PROPN
admet-286	99	10	endpoint	endpoint	NOUN
admet-286	99	11	i.e.	i.e.	X
admet-286	99	12	bacterial	bacterial	ADJ
admet-286	99	13	density	density	NOUN
admet-286	99	14	calculated	calculate	VERB
admet-286	99	15	as	as	ADP
admet-286	99	16	change	change	NOUN
admet-286	99	17	in	in	ADP
admet-286	99	18	log10	log10	PROPN
admet-286	99	19	cfu	cfu	PROPN
admet-286	99	20	/	/	SYM
admet-286	99	21	ml	ml	NOUN
admet-286	99	22	after	after	ADP
admet-286	99	23	8	8	NUM
admet-286	99	24	,	,	PUNCT
admet-286	99	25	9.5	9.5	NUM
admet-286	99	26	,	,	PUNCT
admet-286	99	27	12	12	NUM
admet-286	99	28	or	or	CCONJ
admet-286	99	29	24	24	NUM
admet-286	99	30	h	h	NOUN
admet-286	99	31	of	of	ADP
admet-286	99	32	treatment	treatment	NOUN
admet-286	99	33	,	,	PUNCT
admet-286	99	34	e0	e0	PROPN
admet-286	99	35	is	be	AUX
admet-286	99	36	the	the	DET
admet-286	99	37	baseline	baseline	ADJ
admet-286	99	38	effect	effect	NOUN
admet-286	99	39	i.e.	i.e.	X
admet-286	99	40	pd	pd	X
admet-286	99	41	endpoint	endpoint	NOUN
admet-286	99	42	without	without	ADP
admet-286	99	43	antibiotic	antibiotic	ADJ
admet-286	99	44	treatment	treatment	NOUN
admet-286	99	45	;	;	PUNCT
admet-286	99	46	x	x	X
admet-286	99	47	is	be	AUX
admet-286	99	48	pk	pk	PROPN
admet-286	99	49	/	/	SYM
admet-286	99	50	pd	pd	PROPN
admet-286	99	51	index	index	NOUN
admet-286	99	52	;	;	PUNCT
admet-286	100	1	vishnu	vishnu	PROPN
admet-286	100	2	sharma	sharma	PROPN
admet-286	100	3	et	et	PROPN
admet-286	100	4	al	al	PROPN
admet-286	100	5	.	.	PROPN
admet-286	100	6	admet	admet	PROPN
admet-286	100	7	&	&	CCONJ
admet-286	100	8	dmpk	dmpk	PROPN
admet-286	100	9	4(3	4(3	NUM
admet-286	100	10	)	)	PUNCT
admet-286	100	11	(	(	PUNCT
admet-286	100	12	2016	2016	NUM
admet-286	100	13	)	)	PUNCT
admet-286	100	14	241	241	NUM
admet-286	100	15	-	-	SYM
admet-286	100	16	260	260	NUM
admet-286	100	17	246	246	NUM
admet-286	100	18	pdmax	pdmax	NOUN
admet-286	100	19	is	be	AUX
admet-286	100	20	a	a	DET
admet-286	100	21	maximum	maximum	ADJ
admet-286	100	22	effect	effect	NOUN
admet-286	100	23	;	;	PUNCT
admet-286	100	24	ex50	ex50	PROPN
admet-286	100	25	is	be	AUX
admet-286	100	26	magnitude	magnitude	NOUN
admet-286	100	27	of	of	ADP
admet-286	100	28	x	x	PRON
admet-286	100	29	that	that	PRON
admet-286	100	30	is	be	AUX
admet-286	100	31	needed	need	VERB
admet-286	100	32	to	to	PART
admet-286	100	33	achieve	achieve	VERB
admet-286	100	34	50	50	NUM
admet-286	100	35	%	%	NOUN
admet-286	100	36	of	of	ADP
admet-286	100	37	the	the	DET
admet-286	100	38	pdmax	pdmax	NOUN
admet-286	100	39	;	;	PUNCT
admet-286	100	40	hill	hill	NOUN
admet-286	100	41	is	be	AUX
admet-286	100	42	the	the	DET
admet-286	100	43	sigmoidicity	sigmoidicity	NOUN
admet-286	100	44	factor	factor	NOUN
admet-286	100	45	,	,	PUNCT
admet-286	100	46	reflecting	reflect	VERB
admet-286	100	47	the	the	DET
admet-286	100	48	steepness	steepness	NOUN
admet-286	100	49	of	of	ADP
admet-286	100	50	the	the	DET
admet-286	100	51	relationship	relationship	NOUN
admet-286	100	52	.	.	PUNCT
admet-286	101	1	all	all	DET
admet-286	101	2	data	datum	NOUN
admet-286	101	3	from	from	ADP
admet-286	101	4	the	the	DET
admet-286	101	5	different	different	ADJ
admet-286	101	6	dosing	dosing	NOUN
admet-286	101	7	regimens	regimen	NOUN
admet-286	101	8	was	be	AUX
admet-286	101	9	fitted	fit	VERB
admet-286	101	10	to	to	ADP
admet-286	101	11	above	above	ADV
admet-286	101	12	-	-	PUNCT
admet-286	101	13	mentioned	mention	VERB
admet-286	101	14	model	model	NOUN
admet-286	101	15	(	(	PUNCT
admet-286	101	16	equation	equation	NOUN
admet-286	101	17	2	2	NUM
admet-286	101	18	)	)	PUNCT
admet-286	101	19	.	.	PUNCT
admet-286	102	1	curve	curve	NOUN
admet-286	102	2	fitting	fitting	ADJ
admet-286	102	3	was	be	AUX
admet-286	102	4	performed	perform	VERB
admet-286	102	5	in	in	ADP
admet-286	102	6	graphpad	graphpad	NOUN
admet-286	102	7	prism	prism	NOUN
admet-286	102	8	(	(	PUNCT
admet-286	102	9	version	version	NOUN
admet-286	102	10	4.01	4.01	NUM
admet-286	102	11	,	,	PUNCT
admet-286	102	12	graphpad	graphpad	NOUN
admet-286	102	13	software	software	NOUN
admet-286	102	14	,	,	PUNCT
admet-286	102	15	san	san	PROPN
admet-286	102	16	diego	diego	PROPN
admet-286	102	17	,	,	PUNCT
admet-286	102	18	ca	ca	NOUN
admet-286	102	19	)	)	PUNCT
admet-286	102	20	using	use	VERB
admet-286	102	21	the	the	DET
admet-286	102	22	nonlinear	nonlinear	ADJ
admet-286	102	23	regression	regression	NOUN
admet-286	102	24	analysis	analysis	NOUN
admet-286	102	25	.	.	PUNCT
admet-286	103	1	the	the	DET
admet-286	103	2	coefficients	coefficient	NOUN
admet-286	103	3	of	of	ADP
admet-286	103	4	determination	determination	NOUN
admet-286	103	5	(	(	PUNCT
admet-286	103	6	r	r	NOUN
admet-286	103	7	2	2	NUM
admet-286	103	8	)	)	PUNCT
admet-286	103	9	,	,	PUNCT
admet-286	103	10	sigmoidicity	sigmoidicity	NOUN
admet-286	103	11	factor	factor	NOUN
admet-286	103	12	,	,	PUNCT
admet-286	103	13	and	and	CCONJ
admet-286	103	14	the	the	DET
admet-286	103	15	visual	visual	ADJ
admet-286	103	16	inspection	inspection	NOUN
admet-286	103	17	of	of	ADP
admet-286	103	18	observed	observe	VERB
admet-286	103	19	versus	versus	ADP
admet-286	103	20	predicted	predict	VERB
admet-286	103	21	values	value	NOUN
admet-286	103	22	graphs	graph	NOUN
admet-286	103	23	were	be	AUX
admet-286	103	24	used	use	VERB
admet-286	103	25	to	to	PART
admet-286	103	26	select	select	VERB
admet-286	103	27	the	the	DET
admet-286	103	28	best	good	ADJ
admet-286	103	29	pk	pk	NOUN
admet-286	103	30	/	/	SYM
admet-286	103	31	pd	pd	NOUN
admet-286	103	32	index	index	NOUN
admet-286	103	33	and	and	CCONJ
admet-286	103	34	the	the	DET
admet-286	103	35	best	good	ADJ
admet-286	103	36	predicted	predict	VERB
admet-286	103	37	endpoint	endpoint	NOUN
admet-286	103	38	of	of	ADP
admet-286	103	39	antibacterial	antibacterial	ADJ
admet-286	103	40	effect	effect	NOUN
admet-286	103	41	.	.	PUNCT
admet-286	104	1	anti	anti	ADJ
admet-286	104	2	-	-	ADJ
admet-286	104	3	bacterial	bacterial	ADJ
admet-286	104	4	-	-	PUNCT
admet-286	104	5	pk	pk	NOUN
admet-286	104	6	/	/	SYM
admet-286	104	7	pd	pd	NOUN
admet-286	104	8	modeling	modeling	NOUN
admet-286	104	9	:	:	PUNCT
admet-286	104	10	basic	basic	ADJ
admet-286	104	11	assumption	assumption	NOUN
admet-286	104	12	for	for	ADP
admet-286	104	13	the	the	DET
admet-286	104	14	dependence	dependence	NOUN
admet-286	104	15	of	of	ADP
admet-286	104	16	antibacterial	antibacterial	ADJ
admet-286	104	17	effect	effect	NOUN
admet-286	104	18	is	be	AUX
admet-286	104	19	generally	generally	ADV
admet-286	104	20	based	base	VERB
admet-286	104	21	on	on	ADP
admet-286	104	22	non	non	ADJ
admet-286	104	23	-	-	ADJ
admet-286	104	24	linear	linear	ADJ
admet-286	104	25	relationship	relationship	NOUN
admet-286	104	26	with	with	ADP
admet-286	104	27	concentration	concentration	NOUN
admet-286	104	28	data	datum	NOUN
admet-286	104	29	of	of	ADP
admet-286	104	30	antibiotics	antibiotic	NOUN
admet-286	104	31	.	.	PUNCT
admet-286	105	1	higher	high	ADJ
admet-286	105	2	the	the	DET
admet-286	105	3	sigmoidicity	sigmoidicity	NOUN
admet-286	105	4	factor	factor	NOUN
admet-286	105	5	,	,	PUNCT
admet-286	105	6	lesser	less	ADJ
admet-286	105	7	is	be	AUX
admet-286	105	8	the	the	DET
admet-286	105	9	predictability	predictability	NOUN
admet-286	105	10	of	of	ADP
admet-286	105	11	pd	pd	PROPN
admet-286	105	12	effect	effect	NOUN
admet-286	105	13	with	with	ADP
admet-286	105	14	respect	respect	NOUN
admet-286	105	15	to	to	ADP
admet-286	105	16	pk	pk	NOUN
admet-286	105	17	/	/	SYM
admet-286	105	18	pd	pd	PROPN
admet-286	105	19	index	index	NOUN
admet-286	105	20	.	.	PUNCT
admet-286	106	1	the	the	DET
admet-286	106	2	concentration	concentration	NOUN
admet-286	106	3	-	-	PUNCT
admet-286	106	4	effect	effect	NOUN
admet-286	106	5	relationships	relationship	NOUN
admet-286	106	6	were	be	AUX
admet-286	106	7	incorporated	incorporate	VERB
admet-286	106	8	in	in	ADP
admet-286	106	9	the	the	DET
admet-286	106	10	bacterial	bacterial	ADJ
admet-286	106	11	model	model	NOUN
admet-286	106	12	(	(	PUNCT
admet-286	106	13	equation	equation	NOUN
admet-286	106	14	1	1	NUM
admet-286	106	15	)	)	PUNCT
admet-286	106	16	to	to	PART
admet-286	106	17	predict	predict	VERB
admet-286	106	18	the	the	DET
admet-286	106	19	bacterial	bacterial	ADJ
admet-286	106	20	count	count	NOUN
admet-286	106	21	from	from	ADP
admet-286	106	22	pk	pk	NOUN
admet-286	106	23	/	/	SYM
admet-286	106	24	pd	pd	NOUN
admet-286	106	25	model	model	NOUN
admet-286	107	1	[	[	X
admet-286	107	2	26	26	NUM
admet-286	107	3	-	-	SYM
admet-286	107	4	29	29	NUM
admet-286	107	5	]	]	PUNCT
admet-286	107	6	(	(	PUNCT
admet-286	107	7	equation	equation	NOUN
admet-286	107	8	3	3	NUM
admet-286	107	9	)	)	PUNCT
admet-286	107	10	.	.	PUNCT
admet-286	108	1	in	in	ADP
admet-286	108	2	the	the	DET
admet-286	108	3	constructed	construct	VERB
admet-286	108	4	model	model	NOUN
admet-286	108	5	,	,	PUNCT
admet-286	108	6	the	the	DET
admet-286	108	7	antibacterial	antibacterial	ADJ
admet-286	108	8	effect	effect	NOUN
admet-286	108	9	of	of	ADP
admet-286	108	10	fdc	fdc	PROPN
admet-286	108	11	of	of	ADP
admet-286	108	12	ceftriaxone	ceftriaxone	PROPN
admet-286	108	13	/	/	SYM
admet-286	108	14	vancomycin	vancomycin	PROPN
admet-286	108	15	is	be	AUX
admet-286	108	16	hypothesized	hypothesize	VERB
admet-286	108	17	as	as	ADP
admet-286	108	18	a	a	DET
admet-286	108	19	combination	combination	NOUN
admet-286	108	20	of	of	ADP
admet-286	108	21	bacterial	bacterial	ADJ
admet-286	108	22	growth	growth	NOUN
admet-286	108	23	inhibition	inhibition	NOUN
admet-286	108	24	(	(	PUNCT
admet-286	108	25	kgrowth	kgrowth	NOUN
admet-286	108	26	)	)	PUNCT
admet-286	108	27	and	and	CCONJ
admet-286	108	28	bacterial	bacterial	ADJ
admet-286	108	29	killing	killing	NOUN
admet-286	108	30	enhancement	enhancement	NOUN
admet-286	108	31	(	(	PUNCT
admet-286	108	32	kdeath	kdeath	NOUN
admet-286	108	33	)	)	PUNCT
admet-286	108	34	(	(	PUNCT
admet-286	108	35	figure	figure	NOUN
admet-286	108	36	2	2	NUM
admet-286	108	37	)	)	PUNCT
admet-286	108	38	.	.	PUNCT
admet-286	109	1	(	(	PUNCT
admet-286	109	2	3	3	X
admet-286	109	3	)	)	PUNCT
admet-286	109	4	model	model	NOUN
admet-286	109	5	evaluation	evaluation	NOUN
admet-286	109	6	all	all	DET
admet-286	109	7	data	datum	NOUN
admet-286	109	8	from	from	ADP
admet-286	109	9	the	the	DET
admet-286	109	10	different	different	ADJ
admet-286	109	11	drug	drug	NOUN
admet-286	109	12	exposure	exposure	NOUN
admet-286	109	13	and	and	CCONJ
admet-286	109	14	dosage	dosage	NOUN
admet-286	109	15	regimen	regiman	NOUN
admet-286	109	16	was	be	AUX
admet-286	109	17	fitted	fit	VERB
admet-286	109	18	to	to	ADP
admet-286	109	19	above	above	ADV
admet-286	109	20	-	-	PUNCT
admet-286	109	21	mentioned	mention	VERB
admet-286	109	22	model	model	NOUN
admet-286	109	23	(	(	PUNCT
admet-286	109	24	equation	equation	NOUN
admet-286	109	25	3	3	NUM
admet-286	109	26	)	)	PUNCT
admet-286	109	27	for	for	ADP
admet-286	109	28	the	the	DET
admet-286	109	29	time	time	NOUN
admet-286	109	30	period	period	NOUN
admet-286	109	31	of	of	ADP
admet-286	109	32	8	8	NUM
admet-286	109	33	and	and	CCONJ
admet-286	109	34	24	24	NUM
admet-286	109	35	h	h	NOUN
admet-286	109	36	respectively	respectively	ADV
admet-286	109	37	using	use	VERB
admet-286	109	38	scientist	scientist	NOUN
admet-286	109	39	(	(	PUNCT
admet-286	109	40	micromath	micromath	PROPN
admet-286	109	41	,	,	PUNCT
admet-286	109	42	version	version	NOUN
admet-286	109	43	3.0	3.0	NUM
admet-286	109	44	,	,	PUNCT
admet-286	109	45	saint	saint	PROPN
admet-286	109	46	louis	louis	PROPN
admet-286	109	47	,	,	PUNCT
admet-286	109	48	missouri	missouri	PROPN
admet-286	109	49	,	,	PUNCT
admet-286	109	50	usa	usa	PROPN
admet-286	109	51	)	)	PUNCT
admet-286	109	52	.	.	PUNCT
admet-286	110	1	the	the	DET
admet-286	110	2	95	95	NUM
admet-286	110	3	%	%	NOUN
admet-286	110	4	confidence	confidence	NOUN
admet-286	110	5	intervals	interval	NOUN
admet-286	110	6	were	be	AUX
admet-286	110	7	drawn	draw	VERB
admet-286	110	8	for	for	ADP
admet-286	110	9	all	all	DET
admet-286	110	10	the	the	DET
admet-286	110	11	predicted	predict	VERB
admet-286	110	12	values	value	NOUN
admet-286	110	13	and	and	CCONJ
admet-286	110	14	compared	compare	VERB
admet-286	110	15	with	with	ADP
admet-286	110	16	the	the	DET
admet-286	110	17	observed	observed	ADJ
admet-286	110	18	values	value	NOUN
admet-286	110	19	(	(	PUNCT
admet-286	110	20	obtained	obtain	VERB
admet-286	110	21	from	from	ADP
admet-286	110	22	in	in	ADP
admet-286	110	23	vitro	vitro	X
admet-286	110	24	system	system	NOUN
admet-286	110	25	)	)	PUNCT
admet-286	110	26	.	.	PUNCT
admet-286	111	1	additionally	additionally	ADV
admet-286	111	2	,	,	PUNCT
admet-286	111	3	the	the	DET
admet-286	111	4	coefficients	coefficient	NOUN
admet-286	111	5	of	of	ADP
admet-286	111	6	determination	determination	NOUN
admet-286	111	7	(	(	PUNCT
admet-286	111	8	r2	r2	PROPN
admet-286	111	9	)	)	PUNCT
admet-286	111	10	between	between	ADP
admet-286	111	11	predicted	predict	VERB
admet-286	111	12	and	and	CCONJ
admet-286	111	13	observed	observed	ADJ
admet-286	111	14	data	data	NOUN
admet-286	111	15	values	value	NOUN
admet-286	111	16	were	be	AUX
admet-286	111	17	determined	determine	VERB
admet-286	111	18	and	and	CCONJ
admet-286	111	19	evaluated	evaluate	VERB
admet-286	111	20	for	for	ADP
admet-286	111	21	the	the	DET
admet-286	111	22	validation	validation	NOUN
admet-286	111	23	of	of	ADP
admet-286	111	24	the	the	DET
admet-286	111	25	antibacterial	antibacterial	ADJ
admet-286	111	26	-	-	PUNCT
admet-286	111	27	pk	pk	NOUN
admet-286	111	28	/	/	SYM
admet-286	111	29	pd	pd	PROPN
admet-286	111	30	model	model	NOUN
admet-286	111	31	.	.	PUNCT
admet-286	112	1	monte	monte	PROPN
admet-286	112	2	carlo	carlo	PROPN
admet-286	112	3	simulations	simulation	NOUN
admet-286	112	4	monte	monte	PROPN
admet-286	112	5	carlo	carlo	PROPN
admet-286	112	6	simulations	simulation	NOUN
admet-286	112	7	for	for	ADP
admet-286	112	8	1000	1000	NUM
admet-286	112	9	adult	adult	NOUN
admet-286	112	10	subjects	subject	NOUN
admet-286	112	11	were	be	AUX
admet-286	112	12	performed	perform	VERB
admet-286	112	13	to	to	PART
admet-286	112	14	determine	determine	VERB
admet-286	112	15	how	how	SCONJ
admet-286	112	16	likely	likely	ADV
admet-286	112	17	the	the	DET
admet-286	112	18	fdc	fdc	PROPN
admet-286	112	19	dose	dose	NOUN
admet-286	112	20	of	of	ADP
admet-286	112	21	0.75	0.75	NUM
admet-286	112	22	,	,	PUNCT
admet-286	112	23	1.5	1.5	NUM
admet-286	112	24	,	,	PUNCT
admet-286	112	25	3	3	NUM
admet-286	112	26	,	,	PUNCT
admet-286	112	27	6	6	NUM
admet-286	112	28	,	,	PUNCT
admet-286	112	29	and	and	CCONJ
admet-286	112	30	9	9	NUM
admet-286	112	31	gm	gm	PROPN
admet-286	112	32	would	would	AUX
admet-286	112	33	achieve	achieve	VERB
admet-286	112	34	auccomb	auccomb	NOUN
admet-286	112	35	>	>	ADP
admet-286	112	36	400	400	NUM
admet-286	112	37	and	and	CCONJ
admet-286	112	38	60	60	NUM
admet-286	112	39	%	%	NOUN
admet-286	112	40	t	t	X
admet-286	112	41	>	>	X
admet-286	112	42	miccomb	miccomb	PROPN
admet-286	112	43	at	at	ADP
admet-286	112	44	different	different	ADJ
admet-286	112	45	values	value	NOUN
admet-286	112	46	of	of	ADP
admet-286	112	47	mic	mic	ADJ
admet-286	112	48	i.e.	i.e.	X
admet-286	112	49	1	1	NUM
admet-286	112	50	,	,	PUNCT
admet-286	112	51	4	4	NUM
admet-286	112	52	,	,	PUNCT
admet-286	112	53	8	8	NUM
admet-286	112	54	,	,	PUNCT
admet-286	112	55	16	16	NUM
admet-286	112	56	,	,	PUNCT
admet-286	112	57	3	3	NUM
admet-286	112	58	,	,	PUNCT
admet-286	112	59	64	64	NUM
admet-286	112	60	µg	µg	NOUN
admet-286	112	61	/	/	SYM
admet-286	112	62	ml	ml	NOUN
admet-286	112	63	.	.	PUNCT
admet-286	113	1	the	the	DET
admet-286	113	2	population	population	NOUN
admet-286	113	3	pk	pk	NOUN
admet-286	113	4	parameter	parameter	NOUN
admet-286	113	5	utilized	utilize	VERB
admet-286	113	6	in	in	ADP
admet-286	113	7	simulations	simulation	NOUN
admet-286	113	8	was	be	AUX
admet-286	113	9	clearance	clearance	NOUN
admet-286	113	10	of	of	ADP
admet-286	113	11	0.88	0.88	NUM
admet-286	113	12	+	+	ADJ
admet-286	113	13	/	/	SYM
admet-286	113	14	0.431	0.431	NUM
admet-286	113	15	l	l	NOUN
admet-286	113	16	/	/	SYM
admet-286	113	17	h	h	NOUN
admet-286	114	1	[	[	X
admet-286	114	2	30	30	NUM
admet-286	114	3	]	]	PUNCT
admet-286	114	4	and	and	CCONJ
admet-286	114	5	4.8	4.8	NUM
admet-286	114	6	+	+	ADJ
admet-286	114	7	/-1.9	/-1.9	ADJ
admet-286	114	8	l	l	NOUN
admet-286	114	9	/	/	SYM
admet-286	114	10	h	h	NOUN
admet-286	115	1	[	[	X
admet-286	115	2	31	31	NUM
admet-286	115	3	]	]	PUNCT
admet-286	115	4	for	for	ADP
admet-286	115	5	ceftriaxone	ceftriaxone	NOUN
admet-286	115	6	and	and	CCONJ
admet-286	115	7	vancomycin	vancomycin	PROPN
admet-286	115	8	,	,	PUNCT
admet-286	115	9	respectively	respectively	ADV
admet-286	115	10	.	.	PUNCT
admet-286	116	1	the	the	DET
admet-286	116	2	patient	patient	ADJ
admet-286	116	3	weight	weight	NOUN
admet-286	116	4	is	be	AUX
admet-286	116	5	an	an	DET
admet-286	116	6	important	important	ADJ
admet-286	116	7	covariate	covariate	NOUN
admet-286	116	8	on	on	ADP
admet-286	116	9	drug	drug	NOUN
admet-286	116	10	’s	’s	PART
admet-286	116	11	clearance	clearance	NOUN
admet-286	116	12	,	,	PUNCT
admet-286	116	13	which	which	PRON
admet-286	116	14	was	be	AUX
admet-286	116	15	assumed	assume	VERB
admet-286	116	16	to	to	PART
admet-286	116	17	be	be	AUX
admet-286	116	18	70	70	NUM
admet-286	116	19	kg	kg	NOUN
admet-286	116	20	in	in	ADP
admet-286	116	21	the	the	DET
admet-286	116	22	analysis	analysis	NOUN
admet-286	116	23	.	.	PUNCT
admet-286	117	1	for	for	ADP
admet-286	117	2	auccomb	auccomb	NOUN
admet-286	117	3	,	,	PUNCT
admet-286	117	4	each	each	DET
admet-286	117	5	dose	dose	NOUN
admet-286	117	6	was	be	AUX
admet-286	117	7	divided	divide	VERB
admet-286	117	8	by	by	ADP
admet-286	117	9	the	the	DET
admet-286	117	10	clearance	clearance	NOUN
admet-286	117	11	values	value	NOUN
admet-286	117	12	of	of	ADP
admet-286	117	13	simulated	simulate	VERB
admet-286	117	14	subjects	subject	NOUN
admet-286	117	15	at	at	ADP
admet-286	117	16	all	all	DET
admet-286	117	17	mic	mic	ADJ
admet-286	117	18	values	value	NOUN
admet-286	117	19	.	.	PUNCT
admet-286	118	1	the	the	DET
admet-286	118	2	pta	pta	NOUN
admet-286	118	3	for	for	ADP
admet-286	118	4	auccomb	auccomb	NOUN
admet-286	118	5	was	be	AUX
admet-286	118	6	defined	define	VERB
admet-286	118	7	as	as	ADP
admet-286	118	8	percentage	percentage	NOUN
admet-286	118	9	of	of	ADP
admet-286	118	10	the	the	DET
admet-286	118	11	simulated	simulate	VERB
admet-286	118	12	subjects	subject	NOUN
admet-286	118	13	in	in	ADP
admet-286	118	14	which	which	PRON
admet-286	118	15	auccomb	auccomb	NOUN
admet-286	118	16	was	be	AUX
admet-286	118	17	more	more	ADJ
admet-286	118	18	than	than	ADP
admet-286	118	19	desired	desire	VERB
admet-286	118	20	values	value	NOUN
admet-286	118	21	(	(	PUNCT
admet-286	118	22	i.e.	i.e.	X
admet-286	118	23	400	400	NUM
admet-286	118	24	in	in	ADP
admet-286	118	25	present	present	ADJ
admet-286	118	26	studies	study	NOUN
admet-286	118	27	)	)	PUNCT
admet-286	118	28	.	.	PUNCT
admet-286	119	1	for	for	ADP
admet-286	119	2	%	%	PROPN
admet-286	119	3	t	t	PROPN
admet-286	119	4	>	>	X
admet-286	119	5	miccomb	miccomb	PROPN
admet-286	119	6	,	,	PUNCT
admet-286	119	7	the	the	DET
admet-286	119	8	concentration	concentration	NOUN
admet-286	119	9	-	-	PUNCT
admet-286	119	10	profiles	profile	NOUN
admet-286	119	11	were	be	AUX
admet-286	119	12	generated	generate	VERB
admet-286	119	13	using	use	VERB
admet-286	119	14	cl	cl	NOUN
admet-286	119	15	and	and	CCONJ
admet-286	119	16	vd	vd	NOUN
admet-286	119	17	of	of	ADP
admet-286	119	18	each	each	DET
admet-286	119	19	simulated	simulate	VERB
admet-286	119	20	subjects	subject	NOUN
admet-286	119	21	and	and	CCONJ
admet-286	119	22	%	%	NOUN
admet-286	119	23	t	t	PROPN
admet-286	119	24	>	>	X
admet-286	119	25	miccomb	miccomb	PROPN
admet-286	119	26	was	be	AUX
admet-286	119	27	calculated	calculate	VERB
admet-286	119	28	for	for	ADP
admet-286	119	29	all	all	DET
admet-286	119	30	simulated	simulated	ADJ
admet-286	119	31	subjects	subject	NOUN
admet-286	119	32	for	for	ADP
admet-286	119	33	different	different	ADJ
admet-286	119	34	doses	dose	NOUN
admet-286	119	35	at	at	ADP
admet-286	119	36	all	all	DET
admet-286	119	37	mic	mic	ADJ
admet-286	119	38	values	value	NOUN
admet-286	119	39	.	.	PUNCT
admet-286	120	1	the	the	DET
admet-286	120	2	pta	pta	PROPN
admet-286	120	3	was	be	AUX
admet-286	120	4	then	then	ADV
admet-286	120	5	defined	define	VERB
admet-286	120	6	as	as	ADP
admet-286	120	7	percentage	percentage	NOUN
admet-286	120	8	of	of	ADP
admet-286	120	9	simulated	simulated	ADJ
admet-286	120	10	subjects	subject	NOUN
admet-286	120	11	showing	show	VERB
admet-286	120	12	%	%	PROPN
admet-286	120	13	t	t	PROPN
admet-286	120	14	>	>	X
admet-286	120	15	miccomb	miccomb	NOUN
admet-286	120	16	of	of	ADP
admet-286	120	17	more	more	ADJ
admet-286	120	18	than	than	ADP
admet-286	120	19	60	60	NUM
admet-286	120	20	.	.	PUNCT
admet-286	121	1	data	datum	NOUN
admet-286	121	2	analysis	analysis	NOUN
admet-286	121	3	descriptive	descriptive	ADJ
admet-286	121	4	statistics	statistic	NOUN
admet-286	121	5	were	be	AUX
admet-286	121	6	used	use	VERB
admet-286	121	7	for	for	ADP
admet-286	121	8	reporting	report	VERB
admet-286	121	9	all	all	DET
admet-286	121	10	pk	pk	NOUN
admet-286	121	11	variables	variable	NOUN
admet-286	121	12	and	and	CCONJ
admet-286	121	13	summary	summary	NOUN
admet-286	121	14	tables	table	NOUN
admet-286	121	15	were	be	AUX
admet-286	121	16	prepared	prepare	VERB
admet-286	121	17	using	using	AUX
admet-286	121	18	mean	mean	ADJ
admet-286	121	19	,	,	PUNCT
admet-286	121	20	standard	standard	ADJ
admet-286	121	21	deviation	deviation	NOUN
admet-286	121	22	(	(	PUNCT
admet-286	121	23	sd	sd	NOUN
admet-286	121	24	)	)	PUNCT
admet-286	121	25	,	,	PUNCT
admet-286	121	26	median	median	NOUN
admet-286	121	27	,	,	PUNCT
admet-286	121	28	and	and	CCONJ
admet-286	121	29	range	range	NOUN
admet-286	121	30	(	(	PUNCT
admet-286	121	31	whichever	whichever	PRON
admet-286	121	32	appropriate	appropriate	ADJ
admet-286	121	33	)	)	PUNCT
admet-286	121	34	.	.	PUNCT
admet-286	122	1	log	log	PROPN
admet-286	122	2	transformed	transform	VERB
admet-286	122	3	data	datum	NOUN
admet-286	122	4	was	be	AUX
admet-286	122	5	used	use	VERB
admet-286	122	6	wherever	wherever	SCONJ
admet-286	122	7	applicable	applicable	ADJ
admet-286	122	8	.	.	PUNCT
admet-286	123	1	the	the	DET
admet-286	123	2	statistical	statistical	ADJ
admet-286	123	3	analysis	analysis	NOUN
admet-286	123	4	was	be	AUX
admet-286	123	5	done	do	VERB
admet-286	123	6	using	use	VERB
admet-286	123	7	graphpad	graphpad	NOUN
admet-286	123	8	prism	prism	NOUN
admet-286	123	9	(	(	PUNCT
admet-286	123	10	version	version	NOUN
admet-286	123	11	4.01	4.01	NUM
admet-286	123	12	,	,	PUNCT
admet-286	123	13	graphpad	graphpad	NOUN
admet-286	123	14	software	software	NOUN
admet-286	123	15	,	,	PUNCT
admet-286	123	16	san	san	PROPN
admet-286	123	17	diego	diego	PROPN
admet-286	123	18	,	,	PUNCT
admet-286	123	19	ca	ca	NOUN
admet-286	123	20	)	)	PUNCT
admet-286	123	21	.	.	PUNCT
admet-286	124	1	non	non	ADJ
admet-286	124	2	-	-	ADJ
admet-286	124	3	linear	linear	ADJ
admet-286	124	4	regression	regression	NOUN
admet-286	124	5	analysis	analysis	NOUN
admet-286	124	6	and	and	CCONJ
admet-286	124	7	logistic	logistic	ADJ
admet-286	124	8	regression	regression	NOUN
admet-286	124	9	was	be	AUX
admet-286	124	10	done	do	VERB
admet-286	124	11	for	for	ADP
admet-286	124	12	bacterial	bacterial	ADJ
admet-286	124	13	admet	admet	PROPN
admet-286	124	14	&	&	CCONJ
admet-286	124	15	dmpk	dmpk	PROPN
admet-286	124	16	4(3	4(3	NUM
admet-286	124	17	)	)	PUNCT
admet-286	124	18	(	(	PUNCT
admet-286	124	19	2016	2016	NUM
admet-286	124	20	)	)	PUNCT
admet-286	124	21	241	241	NUM
admet-286	124	22	-	-	SYM
admet-286	124	23	260	260	NUM
admet-286	124	24	dose	dose	NOUN
admet-286	124	25	optimization	optimization	NOUN
admet-286	124	26	of	of	ADP
admet-286	124	27	fdc	fdc	PROPN
admet-286	124	28	against	against	ADP
admet-286	124	29	s.	s.	PROPN
admet-286	124	30	aureus	aureus	PROPN
admet-286	124	31	resistant	resistant	ADJ
admet-286	124	32	bacteria	bacteria	NOUN
admet-286	124	33	doi	doi	NOUN
admet-286	124	34	:	:	PUNCT
admet-286	124	35	10.5599	10.5599	NUM
admet-286	124	36	/	/	SYM
admet-286	124	37	admet.4.3.286	admet.4.3.286	ADJ
admet-286	124	38	247	247	NUM
admet-286	124	39	kinetics	kinetic	NOUN
admet-286	124	40	using	use	VERB
admet-286	124	41	scientist	scientist	NOUN
admet-286	124	42	(	(	PUNCT
admet-286	124	43	micromath	micromath	PROPN
admet-286	124	44	,	,	PUNCT
admet-286	124	45	version	version	NOUN
admet-286	124	46	3.0	3.0	NUM
admet-286	124	47	,	,	PUNCT
admet-286	124	48	saint	saint	PROPN
admet-286	124	49	louis	louis	PROPN
admet-286	124	50	,	,	PUNCT
admet-286	124	51	missouri	missouri	PROPN
admet-286	124	52	,	,	PUNCT
admet-286	124	53	usa	usa	PROPN
admet-286	124	54	)	)	PUNCT
admet-286	124	55	.	.	PUNCT
admet-286	125	1	monte	monte	PROPN
admet-286	125	2	carlo	carlo	PROPN
admet-286	125	3	simulations	simulation	NOUN
admet-286	125	4	were	be	AUX
admet-286	125	5	done	do	VERB
admet-286	125	6	using	use	VERB
admet-286	125	7	macros	macro	NOUN
admet-286	125	8	in	in	ADP
admet-286	125	9	ms	ms	PROPN
admet-286	125	10	excel	excel	PROPN
admet-286	125	11	2010	2010	NUM
admet-286	125	12	.	.	PUNCT
admet-286	126	1	results	result	NOUN
admet-286	126	2	and	and	CCONJ
admet-286	126	3	discussion	discussion	VERB
admet-286	126	4	the	the	DET
admet-286	126	5	major	major	ADJ
admet-286	126	6	problem	problem	NOUN
admet-286	126	7	with	with	ADP
admet-286	126	8	antibacterial	antibacterial	ADJ
admet-286	126	9	resistance	resistance	NOUN
admet-286	126	10	is	be	AUX
admet-286	126	11	limited	limited	ADJ
admet-286	126	12	treatment	treatment	NOUN
admet-286	126	13	options	option	NOUN
admet-286	126	14	.	.	PUNCT
admet-286	127	1	with	with	ADP
admet-286	127	2	limited	limited	ADJ
admet-286	127	3	antibiotic	antibiotic	ADJ
admet-286	127	4	research	research	NOUN
admet-286	127	5	,	,	PUNCT
admet-286	127	6	fdc	fdc	PROPN
admet-286	127	7	of	of	ADP
admet-286	127	8	already	already	ADV
admet-286	127	9	approved	approve	VERB
admet-286	127	10	antibiotic	antibiotic	NOUN
admet-286	127	11	may	may	AUX
admet-286	127	12	still	still	ADV
admet-286	127	13	provide	provide	VERB
admet-286	127	14	certain	certain	ADJ
admet-286	127	15	answers	answer	NOUN
admet-286	127	16	to	to	PART
admet-286	127	17	tackle	tackle	VERB
admet-286	127	18	the	the	DET
admet-286	127	19	resistance	resistance	NOUN
admet-286	127	20	[	[	X
admet-286	127	21	32	32	NUM
admet-286	127	22	]	]	PUNCT
admet-286	127	23	.	.	PUNCT
admet-286	128	1	however	however	ADV
admet-286	128	2	,	,	PUNCT
admet-286	128	3	the	the	DET
admet-286	128	4	major	major	ADJ
admet-286	128	5	concern	concern	NOUN
admet-286	128	6	with	with	ADP
admet-286	128	7	antibiotic	antibiotic	ADJ
admet-286	128	8	fdcs	fdc	NOUN
admet-286	128	9	utilization	utilization	NOUN
admet-286	128	10	is	be	AUX
admet-286	128	11	their	their	PRON
admet-286	128	12	dose	dose	NOUN
admet-286	128	13	and	and	CCONJ
admet-286	128	14	frequency	frequency	NOUN
admet-286	128	15	of	of	ADP
admet-286	128	16	dosing	dose	VERB
admet-286	128	17	.	.	PUNCT
admet-286	129	1	focusing	focus	VERB
admet-286	129	2	on	on	ADP
admet-286	129	3	dose	dose	NOUN
admet-286	129	4	optimization	optimization	NOUN
admet-286	129	5	,	,	PUNCT
admet-286	129	6	it	it	PRON
admet-286	129	7	mainly	mainly	ADV
admet-286	129	8	depends	depend	VERB
admet-286	129	9	upon	upon	SCONJ
admet-286	129	10	the	the	DET
admet-286	129	11	pharmacokinetic	pharmacokinetic	NOUN
admet-286	129	12	,	,	PUNCT
admet-286	129	13	and	and	CCONJ
admet-286	129	14	pharmacodynamic	pharmacodynamic	ADJ
admet-286	129	15	properties	property	NOUN
admet-286	129	16	of	of	ADP
admet-286	129	17	a	a	DET
admet-286	129	18	drug	drug	NOUN
admet-286	129	19	.	.	PUNCT
admet-286	130	1	the	the	DET
admet-286	130	2	complexity	complexity	NOUN
admet-286	130	3	increases	increase	VERB
admet-286	130	4	with	with	ADP
admet-286	130	5	addition	addition	NOUN
admet-286	130	6	of	of	ADP
admet-286	130	7	another	another	DET
admet-286	130	8	active	active	ADJ
admet-286	130	9	drug	drug	NOUN
admet-286	130	10	in	in	ADP
admet-286	130	11	the	the	DET
admet-286	130	12	formulation	formulation	NOUN
admet-286	130	13	,	,	PUNCT
admet-286	130	14	similar	similar	ADJ
admet-286	130	15	to	to	ADP
admet-286	130	16	the	the	DET
admet-286	130	17	one	one	NOUN
admet-286	130	18	presented	present	VERB
admet-286	130	19	in	in	ADP
admet-286	130	20	the	the	DET
admet-286	130	21	study	study	NOUN
admet-286	130	22	.	.	PUNCT
admet-286	131	1	the	the	DET
admet-286	131	2	current	current	ADJ
admet-286	131	3	formulation	formulation	NOUN
admet-286	131	4	is	be	AUX
admet-286	131	5	a	a	DET
admet-286	131	6	fdc	fdc	PROPN
admet-286	131	7	of	of	ADP
admet-286	131	8	ceftriaxone	ceftriaxone	PROPN
admet-286	131	9	and	and	CCONJ
admet-286	131	10	vancomycin	vancomycin	PROPN
admet-286	131	11	in	in	ADP
admet-286	131	12	2:1	2:1	NUM
admet-286	131	13	(	(	PUNCT
admet-286	131	14	w	w	PROPN
admet-286	131	15	/	/	SYM
admet-286	131	16	w	w	NOUN
admet-286	131	17	)	)	PUNCT
admet-286	131	18	,	,	PUNCT
admet-286	131	19	results	result	NOUN
admet-286	131	20	in	in	ADP
admet-286	131	21	reduction	reduction	NOUN
admet-286	131	22	of	of	ADP
admet-286	131	23	combined	combine	VERB
admet-286	131	24	mic	mic	NOUN
admet-286	131	25	from	from	ADP
admet-286	131	26	16	16	NUM
admet-286	131	27	to	to	PART
admet-286	131	28	4	4	NUM
admet-286	131	29	µg	µg	ADV
admet-286	131	30	/	/	SYM
admet-286	131	31	ml	ml	X
admet-286	131	32	against	against	ADP
admet-286	131	33	a	a	DET
admet-286	131	34	mrsa	mrsa	NOUN
admet-286	131	35	bacterial	bacterial	ADJ
admet-286	131	36	strain	strain	NOUN
admet-286	131	37	used	use	VERB
admet-286	131	38	for	for	ADP
admet-286	131	39	this	this	DET
admet-286	131	40	study	study	NOUN
admet-286	131	41	.	.	PUNCT
admet-286	132	1	the	the	DET
admet-286	132	2	fic	fic	ADJ
admet-286	132	3	index	index	NOUN
admet-286	132	4	was	be	AUX
admet-286	132	5	<	<	X
admet-286	132	6	0.5	0.5	NUM
admet-286	132	7	again	again	ADV
admet-286	132	8	confirms	confirm	VERB
admet-286	132	9	the	the	DET
admet-286	132	10	synergism	synergism	NOUN
admet-286	132	11	offered	offer	VERB
admet-286	132	12	by	by	ADP
admet-286	132	13	fdc	fdc	PROPN
admet-286	133	1	[	[	X
admet-286	133	2	5	5	NUM
admet-286	133	3	]	]	PUNCT
admet-286	133	4	.	.	PUNCT
admet-286	134	1	the	the	DET
admet-286	134	2	present	present	ADJ
admet-286	134	3	study	study	NOUN
admet-286	134	4	was	be	AUX
admet-286	134	5	focused	focus	VERB
admet-286	134	6	on	on	ADP
admet-286	134	7	dose	dose	NOUN
admet-286	134	8	optimization	optimization	NOUN
admet-286	134	9	of	of	ADP
admet-286	134	10	the	the	DET
admet-286	134	11	fdc	fdc	PROPN
admet-286	134	12	using	use	VERB
admet-286	134	13	in	in	ADP
admet-286	134	14	vitro	vitro	X
admet-286	134	15	studies	study	NOUN
admet-286	134	16	,	,	PUNCT
admet-286	134	17	pk	pk	NOUN
admet-286	134	18	/	/	SYM
admet-286	134	19	pd	pd	NOUN
admet-286	134	20	modeling	modeling	NOUN
admet-286	134	21	and	and	CCONJ
admet-286	134	22	monte	monte	PROPN
admet-286	134	23	carlo	carlo	PROPN
admet-286	134	24	simulations	simulation	NOUN
admet-286	134	25	.	.	PUNCT
admet-286	135	1	exposure	exposure	NOUN
admet-286	135	2	-	-	PUNCT
admet-286	135	3	response	response	NOUN
admet-286	135	4	relationship	relationship	NOUN
admet-286	135	5	assessment	assessment	NOUN
admet-286	135	6	using	use	VERB
admet-286	135	7	in	in	ADP
admet-286	135	8	vitro	vitro	X
admet-286	135	9	studies	study	NOUN
admet-286	135	10	the	the	DET
admet-286	135	11	in	in	ADP
admet-286	135	12	vitro	vitro	X
admet-286	135	13	models	model	NOUN
admet-286	135	14	allow	allow	VERB
admet-286	135	15	good	good	ADJ
admet-286	135	16	prediction	prediction	NOUN
admet-286	135	17	of	of	ADP
admet-286	135	18	in	in	ADP
admet-286	135	19	vivo	vivo	ADJ
admet-286	135	20	bacterial	bacterial	ADJ
admet-286	135	21	growth	growth	NOUN
admet-286	135	22	in	in	ADP
admet-286	135	23	vivo	vivo	NOUN
admet-286	135	24	,	,	PUNCT
admet-286	135	25	helps	help	VERB
admet-286	135	26	in	in	ADP
admet-286	135	27	comparing	compare	VERB
admet-286	135	28	different	different	ADJ
admet-286	135	29	dosing	dose	VERB
admet-286	135	30	regimens	regimen	NOUN
admet-286	135	31	of	of	ADP
admet-286	135	32	drugs	drug	NOUN
admet-286	135	33	,	,	PUNCT
admet-286	135	34	and	and	CCONJ
admet-286	135	35	thus	thus	ADV
admet-286	135	36	play	play	VERB
admet-286	135	37	an	an	DET
admet-286	135	38	important	important	ADJ
admet-286	135	39	role	role	NOUN
admet-286	135	40	in	in	ADP
admet-286	135	41	dose	dose	NOUN
admet-286	135	42	optimization	optimization	NOUN
admet-286	135	43	[	[	X
admet-286	135	44	21	21	NUM
admet-286	135	45	]	]	PUNCT
admet-286	135	46	.	.	PUNCT
admet-286	136	1	the	the	DET
admet-286	136	2	selection	selection	NOUN
admet-286	136	3	of	of	ADP
admet-286	136	4	a	a	DET
admet-286	136	5	specific	specific	ADJ
admet-286	136	6	in	in	ADP
admet-286	136	7	vitro	vitro	X
admet-286	136	8	model	model	NOUN
admet-286	136	9	is	be	AUX
admet-286	136	10	determined	determine	VERB
admet-286	136	11	by	by	ADP
admet-286	136	12	the	the	DET
admet-286	136	13	objectives	objective	NOUN
admet-286	136	14	of	of	ADP
admet-286	136	15	a	a	DET
admet-286	136	16	pk	pk	NOUN
admet-286	136	17	/	/	SYM
admet-286	136	18	pd	pd	NOUN
admet-286	136	19	study	study	NOUN
admet-286	136	20	.	.	PUNCT
admet-286	137	1	the	the	DET
admet-286	137	2	usual	usual	ADJ
admet-286	137	3	method	method	NOUN
admet-286	137	4	for	for	ADP
admet-286	137	5	testing	testing	NOUN
admet-286	137	6	in	in	ADP
admet-286	137	7	vitro	vitro	X
admet-286	137	8	antibiotic	antibiotic	ADJ
admet-286	137	9	combinations	combination	NOUN
admet-286	137	10	involves	involve	VERB
admet-286	137	11	the	the	DET
admet-286	137	12	exposure	exposure	NOUN
admet-286	137	13	of	of	ADP
admet-286	137	14	a	a	DET
admet-286	137	15	given	give	VERB
admet-286	137	16	bacterial	bacterial	ADJ
admet-286	137	17	inoculum	inoculum	NOUN
admet-286	137	18	to	to	ADP
admet-286	137	19	a	a	DET
admet-286	137	20	static	static	ADJ
admet-286	137	21	concentration	concentration	NOUN
admet-286	137	22	of	of	ADP
admet-286	137	23	the	the	DET
admet-286	137	24	anitbiotics	anitbiotic	NOUN
admet-286	137	25	.	.	PUNCT
admet-286	138	1	however	however	ADV
admet-286	138	2	,	,	PUNCT
admet-286	138	3	bacteria	bacteria	NOUN
admet-286	138	4	at	at	ADP
admet-286	138	5	the	the	DET
admet-286	138	6	site	site	NOUN
admet-286	138	7	of	of	ADP
admet-286	138	8	an	an	DET
admet-286	138	9	infection	infection	NOUN
admet-286	138	10	are	be	AUX
admet-286	138	11	exposed	expose	VERB
admet-286	138	12	in	in	ADP
admet-286	138	13	vivo	vivo	NOUN
admet-286	138	14	to	to	ADP
admet-286	138	15	varying	vary	VERB
admet-286	138	16	concentrations	concentration	NOUN
admet-286	138	17	of	of	ADP
admet-286	138	18	antibiotics	antibiotic	NOUN
admet-286	138	19	.	.	PUNCT
admet-286	139	1	therefore	therefore	ADV
admet-286	139	2	,	,	PUNCT
admet-286	139	3	in	in	ADP
admet-286	139	4	the	the	DET
admet-286	139	5	present	present	ADJ
admet-286	139	6	study	study	NOUN
admet-286	139	7	,	,	PUNCT
admet-286	139	8	we	we	PRON
admet-286	139	9	have	have	AUX
admet-286	139	10	employed	employ	VERB
admet-286	139	11	dynamic	dynamic	ADJ
admet-286	139	12	dilution	dilution	NOUN
admet-286	139	13	in	in	ADP
admet-286	139	14	vitro	vitro	X
admet-286	139	15	system	system	NOUN
admet-286	139	16	i.e.	i.e.	X
admet-286	139	17	one	one	NUM
admet-286	139	18	-	-	PUNCT
admet-286	139	19	compartment	compartment	NOUN
admet-286	139	20	chemostat	chemostat	NOUN
admet-286	139	21	infection	infection	NOUN
admet-286	139	22	model	model	NOUN
admet-286	139	23	to	to	PART
admet-286	139	24	mimic	mimic	VERB
admet-286	139	25	the	the	DET
admet-286	139	26	in	in	ADP
admet-286	139	27	vivo	vivo	ADJ
admet-286	139	28	conditions	condition	NOUN
admet-286	139	29	with	with	ADP
admet-286	139	30	respect	respect	NOUN
admet-286	139	31	to	to	ADP
admet-286	139	32	the	the	DET
admet-286	139	33	changing	change	VERB
admet-286	139	34	drug	drug	NOUN
admet-286	139	35	and	and	CCONJ
admet-286	139	36	medium	medium	NOUN
admet-286	139	37	much	much	ADV
admet-286	139	38	more	more	ADV
admet-286	139	39	closely	closely	ADV
admet-286	139	40	.	.	PUNCT
admet-286	140	1	chemostat	chemostat	PROPN
admet-286	140	2	infection	infection	NOUN
admet-286	140	3	model	model	NOUN
admet-286	140	4	provides	provide	VERB
admet-286	140	5	optimal	optimal	ADJ
admet-286	140	6	bacterial	bacterial	ADJ
admet-286	140	7	growth	growth	NOUN
admet-286	140	8	conditions	condition	NOUN
admet-286	140	9	by	by	ADP
admet-286	140	10	replenishing	replenish	VERB
admet-286	140	11	nutrients	nutrient	NOUN
admet-286	140	12	via	via	ADP
admet-286	140	13	fresh	fresh	ADJ
admet-286	140	14	media	medium	NOUN
admet-286	140	15	,	,	PUNCT
admet-286	140	16	and	and	CCONJ
admet-286	140	17	removing	remove	VERB
admet-286	140	18	drug	drug	NOUN
admet-286	140	19	/	/	SYM
admet-286	140	20	wastes	waste	NOUN
admet-286	140	21	/	/	SYM
admet-286	140	22	old	old	ADJ
admet-286	140	23	media	medium	NOUN
admet-286	140	24	,	,	PUNCT
admet-286	140	25	hence	hence	ADV
admet-286	140	26	mimicking	mimic	VERB
admet-286	140	27	closely	closely	ADV
admet-286	140	28	the	the	DET
admet-286	140	29	biological	biological	ADJ
admet-286	140	30	dynamics	dynamic	NOUN
admet-286	140	31	of	of	ADP
admet-286	140	32	bacteria	bacteria	NOUN
admet-286	140	33	during	during	ADP
admet-286	140	34	human	human	ADJ
admet-286	140	35	infection	infection	NOUN
admet-286	140	36	.	.	PUNCT
admet-286	141	1	the	the	DET
admet-286	141	2	in	in	ADV
admet-286	141	3	vitro	vitro	X
admet-286	141	4	system	system	NOUN
admet-286	141	5	simulates	simulate	VERB
admet-286	141	6	1st	1st	ADJ
admet-286	141	7	order	order	NOUN
admet-286	141	8	drug	drug	NOUN
admet-286	141	9	elimination	elimination	NOUN
admet-286	141	10	leading	lead	VERB
admet-286	141	11	to	to	ADP
admet-286	141	12	exponential	exponential	ADJ
admet-286	141	13	decrease	decrease	NOUN
admet-286	141	14	in	in	ADP
admet-286	141	15	drug	drug	NOUN
admet-286	141	16	concentration	concentration	NOUN
admet-286	141	17	.	.	PUNCT
admet-286	142	1	as	as	SCONJ
admet-286	142	2	both	both	PRON
admet-286	142	3	vancomycin	vancomycin	PROPN
admet-286	142	4	and	and	CCONJ
admet-286	142	5	ceftriaxone	ceftriaxone	PROPN
admet-286	142	6	concentration	concentration	NOUN
admet-286	142	7	-	-	PUNCT
admet-286	142	8	time	time	NOUN
admet-286	142	9	plots	plot	NOUN
admet-286	142	10	follow	follow	VERB
admet-286	142	11	one	one	NUM
admet-286	142	12	compartment	compartment	NOUN
admet-286	142	13	pk	pk	NOUN
admet-286	142	14	model	model	NOUN
admet-286	142	15	,	,	PUNCT
admet-286	142	16	the	the	DET
admet-286	142	17	model	model	NOUN
admet-286	142	18	was	be	AUX
admet-286	142	19	apt	apt	ADJ
admet-286	142	20	to	to	PART
admet-286	142	21	fit	fit	VERB
admet-286	142	22	the	the	DET
admet-286	142	23	first	first	ADJ
admet-286	142	24	order	order	NOUN
admet-286	142	25	kinetics	kinetic	NOUN
admet-286	142	26	of	of	ADP
admet-286	142	27	both	both	DET
admet-286	142	28	drugs	drug	NOUN
admet-286	142	29	.	.	PUNCT
admet-286	143	1	the	the	DET
admet-286	143	2	in	in	ADV
admet-286	143	3	vitro	vitro	X
admet-286	143	4	model	model	NOUN
admet-286	143	5	for	for	ADP
admet-286	143	6	dose	dose	NOUN
admet-286	143	7	optimization	optimization	NOUN
admet-286	143	8	requires	require	VERB
admet-286	143	9	pk	pk	NOUN
admet-286	143	10	and	and	CCONJ
admet-286	143	11	pd	pd	PROPN
admet-286	143	12	inputs	input	NOUN
admet-286	143	13	to	to	PART
admet-286	143	14	evaluate	evaluate	VERB
admet-286	143	15	the	the	DET
admet-286	143	16	pk	pk	NOUN
admet-286	143	17	/	/	SYM
admet-286	143	18	pd	pd	NOUN
admet-286	143	19	of	of	ADP
admet-286	143	20	a	a	DET
admet-286	143	21	given	give	VERB
admet-286	143	22	exposure	exposure	NOUN
admet-286	143	23	of	of	ADP
admet-286	143	24	drug	drug	NOUN
admet-286	143	25	against	against	ADP
admet-286	143	26	an	an	DET
admet-286	143	27	infection	infection	NOUN
admet-286	143	28	.	.	PUNCT
admet-286	144	1	for	for	ADP
admet-286	144	2	pk	pk	NOUN
admet-286	144	3	input	input	NOUN
admet-286	144	4	,	,	PUNCT
admet-286	144	5	the	the	DET
admet-286	144	6	pk	pk	NOUN
admet-286	144	7	parameters	parameter	NOUN
admet-286	144	8	reported	report	VERB
admet-286	144	9	in	in	ADP
admet-286	144	10	literature	literature	NOUN
admet-286	144	11	for	for	ADP
admet-286	144	12	ceftriaxone	ceftriaxone	NOUN
admet-286	144	13	and	and	CCONJ
admet-286	144	14	vancomycin	vancomycin	PROPN
admet-286	144	15	were	be	AUX
admet-286	144	16	employed	employ	VERB
admet-286	144	17	(	(	PUNCT
admet-286	144	18	table	table	NOUN
admet-286	144	19	1	1	NUM
admet-286	144	20	)	)	PUNCT
admet-286	144	21	.	.	PUNCT
admet-286	145	1	focusing	focus	VERB
admet-286	145	2	on	on	ADP
admet-286	145	3	pd	pd	PROPN
admet-286	145	4	target	target	PROPN
admet-286	145	5	,	,	PUNCT
admet-286	145	6	mrsa	mrsa	NOUN
admet-286	145	7	isolates	isolate	NOUN
admet-286	145	8	were	be	AUX
admet-286	145	9	selected	select	VERB
admet-286	145	10	as	as	ADP
admet-286	145	11	a	a	DET
admet-286	145	12	prototype	prototype	NOUN
admet-286	145	13	of	of	ADP
admet-286	145	14	mrsa	mrsa	NOUN
admet-286	145	15	infections	infection	NOUN
admet-286	145	16	.	.	PUNCT
admet-286	146	1	microbiological	microbiological	ADJ
admet-286	146	2	studies	study	NOUN
admet-286	146	3	were	be	AUX
admet-286	146	4	then	then	ADV
admet-286	146	5	performed	perform	VERB
admet-286	146	6	for	for	ADP
admet-286	146	7	the	the	DET
admet-286	146	8	selection	selection	NOUN
admet-286	146	9	of	of	ADP
admet-286	146	10	the	the	DET
admet-286	146	11	target	target	NOUN
admet-286	146	12	strain	strain	NOUN
admet-286	146	13	against	against	SCONJ
admet-286	146	14	which	which	DET
admet-286	146	15	exposure	exposure	NOUN
admet-286	146	16	-	-	PUNCT
admet-286	146	17	response	response	NOUN
admet-286	146	18	relationship	relationship	NOUN
admet-286	146	19	can	can	AUX
admet-286	146	20	be	be	AUX
admet-286	146	21	evaluated	evaluate	VERB
admet-286	146	22	.	.	PUNCT
admet-286	147	1	it	it	PRON
admet-286	147	2	was	be	AUX
admet-286	147	3	observed	observe	VERB
admet-286	147	4	that	that	SCONJ
admet-286	147	5	mrsa	mrsa	NOUN
admet-286	147	6	strain	strain	NOUN
admet-286	147	7	of	of	ADP
admet-286	147	8	mic	mic	ADJ
admet-286	147	9	4	4	NUM
admet-286	147	10	µg	µg	NOUN
admet-286	147	11	/	/	SYM
admet-286	147	12	ml	ml	NOUN
admet-286	147	13	exhibits	exhibit	NOUN
admet-286	147	14	dose	dose	NOUN
admet-286	147	15	-	-	PUNCT
admet-286	147	16	dependent	dependent	ADJ
admet-286	147	17	behaviour	behaviour	NOUN
admet-286	147	18	against	against	ADP
admet-286	147	19	the	the	DET
admet-286	147	20	fdc	fdc	PROPN
admet-286	147	21	,	,	PUNCT
admet-286	147	22	which	which	PRON
admet-286	147	23	underlines	underline	VERB
admet-286	147	24	its	its	PRON
admet-286	147	25	suitability	suitability	NOUN
admet-286	147	26	in	in	ADP
admet-286	147	27	exposure	exposure	NOUN
admet-286	147	28	-	-	PUNCT
admet-286	147	29	response	response	NOUN
admet-286	147	30	studies	study	NOUN
admet-286	147	31	(	(	PUNCT
admet-286	147	32	results	result	NOUN
admet-286	147	33	not	not	PART
admet-286	147	34	shown	show	VERB
admet-286	147	35	)	)	PUNCT
admet-286	147	36	.	.	PUNCT
admet-286	148	1	the	the	DET
admet-286	148	2	pd	pd	PROPN
admet-286	148	3	effect	effect	NOUN
admet-286	148	4	was	be	AUX
admet-286	148	5	defined	define	VERB
admet-286	148	6	as	as	ADP
admet-286	148	7	logarithmic	logarithmic	ADJ
admet-286	148	8	reduction	reduction	NOUN
admet-286	148	9	in	in	ADP
admet-286	148	10	mrsa	mrsa	NOUN
admet-286	148	11	bacterial	bacterial	ADJ
admet-286	148	12	densities	density	NOUN
admet-286	148	13	over	over	ADP
admet-286	148	14	24	24	NUM
admet-286	148	15	h	h	NOUN
admet-286	148	16	time	time	NOUN
admet-286	148	17	period	period	NOUN
admet-286	148	18	.	.	PUNCT
admet-286	149	1	the	the	DET
admet-286	149	2	mrsa	mrsa	NOUN
admet-286	149	3	infection	infection	NOUN
admet-286	149	4	was	be	AUX
admet-286	149	5	treated	treat	VERB
admet-286	149	6	with	with	ADP
admet-286	149	7	seven	seven	NUM
admet-286	149	8	different	different	ADJ
admet-286	149	9	exposures	exposure	NOUN
admet-286	149	10	(	(	PUNCT
admet-286	149	11	0.5	0.5	NUM
admet-286	149	12	-	-	SYM
admet-286	149	13	200	200	NUM
admet-286	149	14	folds	fold	NOUN
admet-286	149	15	of	of	ADP
admet-286	149	16	mic	mic	ADJ
admet-286	149	17	4	4	NUM
admet-286	149	18	µg	µg	NOUN
admet-286	149	19	/	/	SYM
admet-286	149	20	ml	ml	NOUN
admet-286	149	21	)	)	PUNCT
admet-286	149	22	of	of	ADP
admet-286	149	23	the	the	DET
admet-286	149	24	fdc	fdc	PROPN
admet-286	149	25	for	for	ADP
admet-286	149	26	24	24	NUM
admet-286	149	27	h	h	NOUN
admet-286	149	28	to	to	PART
admet-286	149	29	find	find	VERB
admet-286	149	30	pk	pk	NOUN
admet-286	149	31	/	/	SYM
admet-286	149	32	pd	pd	NOUN
admet-286	149	33	driver	driver	NOUN
admet-286	149	34	that	that	PRON
admet-286	149	35	can	can	AUX
admet-286	149	36	best	well	ADV
admet-286	149	37	describe	describe	VERB
admet-286	149	38	the	the	DET
admet-286	149	39	pd	pd	PROPN
admet-286	149	40	effect	effect	NOUN
admet-286	149	41	.	.	PUNCT
admet-286	150	1	it	it	PRON
admet-286	150	2	was	be	AUX
admet-286	150	3	noted	note	VERB
admet-286	150	4	that	that	SCONJ
admet-286	150	5	bacterial	bacterial	ADJ
admet-286	150	6	killing	killing	NOUN
admet-286	150	7	increase	increase	NOUN
admet-286	150	8	with	with	ADP
admet-286	150	9	increase	increase	NOUN
admet-286	150	10	in	in	ADP
admet-286	150	11	drug	drug	NOUN
admet-286	150	12	exposure	exposure	NOUN
admet-286	150	13	till	till	SCONJ
admet-286	150	14	the	the	DET
admet-286	150	15	saturation	saturation	NOUN
admet-286	150	16	is	be	AUX
admet-286	150	17	achieved	achieve	VERB
admet-286	150	18	(	(	PUNCT
admet-286	150	19	figure	figure	NOUN
admet-286	150	20	3	3	NUM
admet-286	150	21	and	and	CCONJ
admet-286	150	22	table	table	NOUN
admet-286	150	23	s1	s1	NOUN
admet-286	150	24	)	)	PUNCT
admet-286	150	25	.	.	PUNCT
admet-286	151	1	after	after	ADP
admet-286	151	2	saturation	saturation	NOUN
admet-286	151	3	(	(	PUNCT
admet-286	151	4	>	>	X
admet-286	151	5	50	50	NUM
admet-286	151	6	fold	fold	ADJ
admet-286	151	7	mic	mic	NOUN
admet-286	151	8	)	)	PUNCT
admet-286	151	9	,	,	PUNCT
admet-286	151	10	there	there	PRON
admet-286	151	11	was	be	VERB
admet-286	151	12	no	no	DET
admet-286	151	13	substantial	substantial	ADJ
admet-286	151	14	increase	increase	NOUN
admet-286	151	15	in	in	ADP
admet-286	151	16	antibacterial	antibacterial	ADJ
admet-286	151	17	effect	effect	NOUN
admet-286	151	18	.	.	PUNCT
admet-286	152	1	thus	thus	ADV
admet-286	152	2	50	50	NUM
admet-286	152	3	folds	fold	NOUN
admet-286	152	4	of	of	ADP
admet-286	152	5	mic	mic	ADJ
admet-286	152	6	(	(	PUNCT
admet-286	152	7	133.5	133.5	NUM
admet-286	152	8	µg	µg	NOUN
admet-286	152	9	/	/	SYM
admet-286	152	10	ml	ml	NOUN
admet-286	152	11	of	of	ADP
admet-286	152	12	ceftriaxone	ceftriaxone	NOUN
admet-286	152	13	and	and	CCONJ
admet-286	152	14	66.75	66.75	NUM
admet-286	152	15	µg	µg	NOUN
admet-286	152	16	/	/	SYM
admet-286	152	17	ml	ml	NOUN
admet-286	152	18	of	of	ADP
admet-286	152	19	vancomycin	vancomycin	PROPN
admet-286	152	20	)	)	PUNCT
admet-286	152	21	was	be	AUX
admet-286	152	22	the	the	DET
admet-286	152	23	lowest	low	ADJ
admet-286	152	24	exposure	exposure	NOUN
admet-286	152	25	for	for	ADP
admet-286	152	26	which	which	PRON
admet-286	152	27	maximum	maximum	ADJ
admet-286	152	28	pd	pd	ADJ
admet-286	152	29	effect	effect	NOUN
admet-286	152	30	was	be	AUX
admet-286	152	31	observed	observe	VERB
admet-286	152	32	;	;	PUNCT
admet-286	152	33	and	and	CCONJ
admet-286	152	34	thus	thus	ADV
admet-286	152	35	the	the	DET
admet-286	152	36	exposure	exposure	NOUN
admet-286	152	37	(	(	PUNCT
admet-286	152	38	50x	50x	ADP
admet-286	152	39	mic	mic	NOUN
admet-286	152	40	)	)	PUNCT
admet-286	152	41	was	be	AUX
admet-286	152	42	selected	select	VERB
admet-286	152	43	for	for	ADP
admet-286	152	44	further	further	ADJ
admet-286	152	45	dose	dose	NOUN
admet-286	152	46	optimization	optimization	NOUN
admet-286	152	47	studies	study	NOUN
admet-286	152	48	.	.	PUNCT
admet-286	153	1	vishnu	vishnu	PROPN
admet-286	153	2	sharma	sharma	PROPN
admet-286	153	3	et	et	PROPN
admet-286	153	4	al	al	PROPN
admet-286	153	5	.	.	PROPN
admet-286	153	6	admet	admet	PROPN
admet-286	153	7	&	&	CCONJ
admet-286	153	8	dmpk	dmpk	PROPN
admet-286	153	9	4(3	4(3	NUM
admet-286	153	10	)	)	PUNCT
admet-286	153	11	(	(	PUNCT
admet-286	153	12	2016	2016	NUM
admet-286	153	13	)	)	PUNCT
admet-286	153	14	241	241	NUM
admet-286	153	15	-	-	SYM
admet-286	153	16	260	260	NUM
admet-286	153	17	248	248	NUM
admet-286	153	18	figure	figure	NOUN
admet-286	153	19	3	3	NUM
admet-286	153	20	.	.	PUNCT
admet-286	153	21	total	total	ADJ
admet-286	153	22	exposure	exposure	NOUN
admet-286	153	23	in	in	ADP
admet-286	153	24	terms	term	NOUN
admet-286	153	25	of	of	ADP
admet-286	153	26	fold	fold	NOUN
admet-286	153	27	in	in	ADP
admet-286	153	28	mics	mic	NOUN
admet-286	153	29	was	be	AUX
admet-286	153	30	plotted	plot	VERB
admet-286	153	31	against	against	ADP
admet-286	153	32	log	log	NOUN
admet-286	153	33	fold	fold	NOUN
admet-286	153	34	change	change	NOUN
admet-286	153	35	in	in	ADP
admet-286	153	36	bacterial	bacterial	ADJ
admet-286	153	37	density	density	NOUN
admet-286	153	38	(	(	PUNCT
admet-286	153	39	cfu	cfu	NOUN
admet-286	153	40	)	)	PUNCT
admet-286	153	41	.	.	PUNCT
admet-286	154	1	downward	downward	ADJ
admet-286	154	2	arrow	arrow	NOUN
admet-286	154	3	represents	represent	VERB
admet-286	154	4	the	the	DET
admet-286	154	5	50	50	NUM
admet-286	154	6	fold	fold	NOUN
admet-286	154	7	mic	mic	NOUN
admet-286	154	8	where	where	SCONJ
admet-286	154	9	the	the	DET
admet-286	154	10	saturated	saturate	VERB
admet-286	154	11	pharmacodynamic	pharmacodynamic	ADJ
admet-286	154	12	response	response	NOUN
admet-286	154	13	was	be	AUX
admet-286	154	14	observed	observe	VERB
admet-286	154	15	.	.	PUNCT
admet-286	155	1	the	the	DET
admet-286	155	2	same	same	ADJ
admet-286	155	3	drug	drug	NOUN
admet-286	155	4	exposure	exposure	NOUN
admet-286	155	5	was	be	AUX
admet-286	155	6	thus	thus	ADV
admet-286	155	7	used	use	VERB
admet-286	155	8	in	in	ADP
admet-286	155	9	dose	dose	NOUN
admet-286	155	10	fractionation	fractionation	NOUN
admet-286	155	11	studies	study	NOUN
admet-286	155	12	for	for	ADP
admet-286	155	13	dose	dose	NOUN
admet-286	155	14	optimization	optimization	NOUN
admet-286	155	15	using	use	VERB
admet-286	155	16	in	in	ADP
admet-286	155	17	vitro	vitro	X
admet-286	155	18	studies	study	NOUN
admet-286	155	19	.	.	PUNCT
admet-286	156	1	table	table	NOUN
admet-286	156	2	1	1	NUM
admet-286	156	3	.	.	PUNCT
admet-286	156	4	pharmacokinetic	pharmacokinetic	ADJ
admet-286	156	5	parameters	parameter	NOUN
admet-286	156	6	estimated	estimate	VERB
admet-286	156	7	in	in	ADP
admet-286	156	8	chemostat	chemostat	NOUN
admet-286	156	9	infection	infection	NOUN
admet-286	156	10	model	model	NOUN
admet-286	156	11	and	and	CCONJ
admet-286	156	12	its	its	PRON
admet-286	156	13	comparison	comparison	NOUN
admet-286	156	14	to	to	ADP
admet-286	156	15	reported	report	VERB
admet-286	156	16	values	value	NOUN
admet-286	156	17	in	in	ADP
admet-286	156	18	literature	literature	NOUN
admet-286	156	19	parameters	parameter	NOUN
admet-286	156	20	as	as	SCONJ
admet-286	156	21	reported	report	VERB
admet-286	156	22	in	in	ADP
admet-286	156	23	literatures	literature	NOUN
admet-286	156	24	estimated	estimate	VERB
admet-286	156	25	from	from	ADP
admet-286	156	26	in	in	ADP
admet-286	156	27	vitro	vitro	X
admet-286	156	28	system	system	NOUN
admet-286	156	29	ceftriaxone	ceftriaxone	PROPN
admet-286	156	30	vancomycin	vancomycin	PROPN
admet-286	156	31	ceftriaxone	ceftriaxone	PROPN
admet-286	156	32	vancomycin	vancomycin	PROPN
admet-286	156	33	clearance	clearance	PROPN
admet-286	156	34	(	(	PUNCT
admet-286	156	35	l	l	NOUN
admet-286	156	36	/	/	SYM
admet-286	156	37	h	h	NOUN
admet-286	156	38	)	)	PUNCT
admet-286	156	39	0.88	0.88	NUM
admet-286	156	40	±	±	NOUN
admet-286	156	41	0.431	0.431	NUM
admet-286	156	42	[	[	X
admet-286	156	43	30	30	NUM
admet-286	156	44	]	]	SYM
admet-286	156	45	4.8	4.8	NUM
admet-286	156	46	±	±	NUM
admet-286	156	47	1.9	1.9	NUM
admet-286	156	48	[	[	X
admet-286	156	49	31	31	NUM
admet-286	156	50	]	]	SYM
admet-286	156	51	1.53	1.53	NUM
admet-286	156	52	±	±	NUM
admet-286	156	53	0.11	0.11	NUM
admet-286	156	54	3.59	3.59	NUM
admet-286	156	55	±	±	NUM
admet-286	156	56	0.11	0.11	NUM
admet-286	156	57	volume	volume	NOUN
admet-286	156	58	of	of	ADP
admet-286	156	59	distribution	distribution	NOUN
admet-286	156	60	(	(	PUNCT
admet-286	156	61	l	l	NOUN
admet-286	156	62	)	)	PUNCT
admet-286	156	63	10.1	10.1	NUM
admet-286	156	64	±	±	NUM
admet-286	156	65	1.0	1.0	NUM
admet-286	157	1	[	[	X
admet-286	157	2	24	24	NUM
admet-286	157	3	]	]	SYM
admet-286	157	4	25.8	25.8	NUM
admet-286	157	5	[	[	X
admet-286	157	6	33	33	NUM
admet-286	157	7	]	]	SYM
admet-286	157	8	10.79	10.79	NUM
admet-286	157	9	±	±	NUM
admet-286	157	10	1.14	1.14	NUM
admet-286	157	11	22.3	22.3	NUM
admet-286	157	12	±	±	NUM
admet-286	157	13	0.67	0.67	NUM
admet-286	157	14	half	half	NOUN
admet-286	157	15	life	life	NOUN
admet-286	157	16	(	(	PUNCT
admet-286	157	17	h	h	NOUN
admet-286	157	18	)	)	PUNCT
admet-286	157	19	5.9	5.9	NUM
admet-286	157	20	±	±	NOUN
admet-286	157	21	0.7	0.7	NUM
admet-286	158	1	[	[	X
admet-286	158	2	24	24	NUM
admet-286	158	3	]	]	SYM
admet-286	158	4	4	4	NUM
admet-286	158	5	-	-	SYM
admet-286	158	6	6	6	NUM
admet-286	158	7	[	[	SYM
admet-286	158	8	34	34	NUM
admet-286	158	9	]	]	SYM
admet-286	158	10	4.83	4.83	NUM
admet-286	158	11	±	±	NUM
admet-286	158	12	0.71	0.71	NUM
admet-286	158	13	4.3	4.3	NUM
admet-286	158	14	±	±	NUM
admet-286	158	15	0.33	0.33	NUM
admet-286	158	16	selection	selection	NOUN
admet-286	158	17	of	of	ADP
admet-286	158	18	pharmacokinetic	pharmacokinetic	ADJ
admet-286	158	19	/	/	SYM
admet-286	158	20	pharmacodynamic	pharmacodynamic	ADJ
admet-286	158	21	driver	driver	NOUN
admet-286	158	22	that	that	PRON
admet-286	158	23	can	can	AUX
admet-286	158	24	predict	predict	VERB
admet-286	158	25	fdc	fdc	PROPN
admet-286	158	26	’s	’s	PART
admet-286	158	27	antibacterial	antibacterial	ADJ
admet-286	158	28	efficacy	efficacy	NOUN
admet-286	158	29	the	the	DET
admet-286	158	30	routine	routine	ADJ
admet-286	158	31	pk	pk	PROPN
admet-286	158	32	/	/	SYM
admet-286	158	33	pd	pd	PROPN
admet-286	158	34	indices	index	NOUN
admet-286	158	35	i.e.	i.e.	X
admet-286	158	36	auc	auc	NOUN
admet-286	158	37	/	/	SYM
admet-286	158	38	mic	mic	ADJ
admet-286	158	39	,	,	PUNCT
admet-286	158	40	cmax	cmax	NOUN
admet-286	158	41	/	/	SYM
admet-286	158	42	mic	mic	ADJ
admet-286	158	43	and	and	CCONJ
admet-286	158	44	%	%	NOUN
admet-286	158	45	t	t	PROPN
admet-286	158	46	>	>	X
admet-286	158	47	mic	mic	NOUN
admet-286	158	48	were	be	AUX
admet-286	158	49	calculated	calculate	VERB
admet-286	158	50	for	for	ADP
admet-286	158	51	ceftriaxone	ceftriaxone	NOUN
admet-286	158	52	and	and	CCONJ
admet-286	158	53	vancomycin	vancomycin	PROPN
admet-286	158	54	individually	individually	ADV
admet-286	158	55	,	,	PUNCT
admet-286	158	56	for	for	ADP
admet-286	158	57	all	all	DET
admet-286	158	58	exposures	exposure	NOUN
admet-286	158	59	.	.	PUNCT
admet-286	159	1	to	to	PART
admet-286	159	2	understand	understand	VERB
admet-286	159	3	of	of	ADP
admet-286	159	4	pk	pk	PROPN
admet-286	159	5	/	/	SYM
admet-286	159	6	pd	pd	PROPN
admet-286	159	7	driver	driver	NOUN
admet-286	159	8	responsible	responsible	ADJ
admet-286	159	9	for	for	ADP
admet-286	159	10	therapeutic	therapeutic	ADJ
admet-286	159	11	potential	potential	NOUN
admet-286	159	12	of	of	ADP
admet-286	159	13	the	the	DET
admet-286	159	14	fdc	fdc	PROPN
admet-286	159	15	,	,	PUNCT
admet-286	159	16	the	the	DET
admet-286	159	17	fic	fic	ADJ
admet-286	159	18	-	-	PUNCT
admet-286	159	19	time	time	NOUN
admet-286	159	20	profiles	profile	NOUN
admet-286	159	21	were	be	AUX
admet-286	159	22	generated	generate	VERB
admet-286	159	23	from	from	ADP
admet-286	159	24	concentration	concentration	NOUN
admet-286	159	25	-	-	PUNCT
admet-286	159	26	time	time	NOUN
admet-286	159	27	profile	profile	NOUN
admet-286	159	28	of	of	ADP
admet-286	159	29	both	both	DET
admet-286	159	30	drugs	drug	NOUN
admet-286	159	31	for	for	ADP
admet-286	159	32	all	all	DET
admet-286	159	33	doses	dose	NOUN
admet-286	159	34	as	as	SCONJ
admet-286	159	35	described	describe	VERB
admet-286	159	36	above	above	ADV
admet-286	159	37	(	(	PUNCT
admet-286	159	38	see	see	VERB
admet-286	159	39	pk	pk	NOUN
admet-286	159	40	/	/	SYM
admet-286	159	41	pd	pd	NOUN
admet-286	159	42	analyses	analysis	NOUN
admet-286	159	43	in	in	ADP
admet-286	159	44	materials	material	NOUN
admet-286	159	45	and	and	CCONJ
admet-286	159	46	method	method	NOUN
admet-286	159	47	section	section	NOUN
admet-286	159	48	)	)	PUNCT
admet-286	159	49	.	.	PUNCT
admet-286	160	1	the	the	DET
admet-286	160	2	pk	pk	PROPN
admet-286	160	3	/	/	SYM
admet-286	160	4	pd	pd	PROPN
admet-286	160	5	indices	index	NOUN
admet-286	160	6	i.e.	i.e.	X
admet-286	160	7	auccomb	auccomb	NOUN
admet-286	160	8	,	,	PUNCT
admet-286	160	9	cmax	cmax	NOUN
admet-286	160	10	-	-	PUNCT
admet-286	160	11	comb	comb	NOUN
admet-286	160	12	,	,	PUNCT
admet-286	160	13	%	%	INTJ
admet-286	160	14	t	t	X
admet-286	160	15	>	>	X
admet-286	160	16	miccomb	miccomb	PROPN
admet-286	160	17	and	and	CCONJ
admet-286	160	18	%	%	INTJ
admet-286	160	19	t	t	PROPN
admet-286	160	20	>	>	X
admet-286	160	21	fic	fic	NOUN
admet-286	160	22	were	be	AUX
admet-286	160	23	calculated	calculate	VERB
admet-286	160	24	from	from	ADP
admet-286	160	25	the	the	DET
admet-286	160	26	fic	fic	ADJ
admet-286	160	27	-	-	PUNCT
admet-286	160	28	time	time	NOUN
admet-286	160	29	curves	curve	NOUN
admet-286	160	30	.	.	PUNCT
admet-286	161	1	all	all	DET
admet-286	161	2	pk	pk	PROPN
admet-286	161	3	/	/	SYM
admet-286	161	4	pd	pd	NOUN
admet-286	161	5	indices	index	NOUN
admet-286	161	6	and	and	CCONJ
admet-286	161	7	their	their	PRON
admet-286	161	8	respective	respective	ADJ
admet-286	161	9	logarithmic	logarithmic	ADJ
admet-286	161	10	transformed	transform	VERB
admet-286	161	11	values	value	NOUN
admet-286	161	12	(	(	PUNCT
admet-286	161	13	excluding	exclude	VERB
admet-286	161	14	%	%	NOUN
admet-286	161	15	t	t	PROPN
admet-286	161	16	>	>	X
admet-286	161	17	miccomb	miccomb	PROPN
admet-286	162	1	and	and	CCONJ
admet-286	162	2	%	%	INTJ
admet-286	162	3	t	t	PROPN
admet-286	162	4	>	>	X
admet-286	162	5	fic	fic	NOUN
admet-286	162	6	)	)	PUNCT
admet-286	162	7	were	be	AUX
admet-286	162	8	plotted	plot	VERB
admet-286	162	9	against	against	ADP
admet-286	162	10	the	the	DET
admet-286	162	11	logarithmic	logarithmic	ADJ
admet-286	162	12	reduction	reduction	NOUN
admet-286	162	13	in	in	ADP
admet-286	162	14	bacterial	bacterial	ADJ
admet-286	162	15	densities	density	NOUN
admet-286	162	16	of	of	ADP
admet-286	162	17	mrsa	mrsa	NOUN
admet-286	162	18	in	in	ADP
admet-286	162	19	8	8	NUM
admet-286	162	20	,	,	PUNCT
admet-286	162	21	9.5	9.5	NUM
admet-286	162	22	,	,	PUNCT
admet-286	162	23	12	12	NUM
admet-286	162	24	and	and	CCONJ
admet-286	162	25	24	24	NUM
admet-286	162	26	h.	h.	NOUN
admet-286	162	27	the	the	DET
admet-286	162	28	time	time	NOUN
admet-286	162	29	periods	period	NOUN
admet-286	162	30	of	of	ADP
admet-286	162	31	8	8	NUM
admet-286	162	32	,	,	PUNCT
admet-286	162	33	12	12	NUM
admet-286	162	34	and	and	CCONJ
admet-286	162	35	24	24	NUM
admet-286	162	36	h	h	NOUN
admet-286	162	37	were	be	AUX
admet-286	162	38	chosen	choose	VERB
admet-286	162	39	considering	consider	VERB
admet-286	162	40	thrice	thrice	NOUN
admet-286	162	41	-	-	PUNCT
admet-286	162	42	a	a	DET
admet-286	162	43	-	-	PUNCT
admet-286	162	44	day	day	NOUN
admet-286	162	45	,	,	PUNCT
admet-286	162	46	twice	twice	DET
admet-286	162	47	-	-	PUNCT
admet-286	162	48	a	a	DET
admet-286	162	49	-	-	PUNCT
admet-286	162	50	day	day	NOUN
admet-286	162	51	and	and	CCONJ
admet-286	162	52	once	once	ADV
admet-286	162	53	-	-	PUNCT
admet-286	162	54	a	a	DET
admet-286	162	55	-	-	PUNCT
admet-286	162	56	day	day	NOUN
admet-286	162	57	regimen	regimen	NOUN
admet-286	162	58	of	of	ADP
admet-286	162	59	the	the	DET
admet-286	162	60	fdc	fdc	PROPN
admet-286	162	61	.	.	PUNCT
admet-286	163	1	the	the	DET
admet-286	163	2	time	time	NOUN
admet-286	163	3	point	point	NOUN
admet-286	163	4	of	of	ADP
admet-286	163	5	9.5	9.5	NUM
admet-286	163	6	h	h	NOUN
admet-286	163	7	was	be	AUX
admet-286	163	8	included	include	VERB
admet-286	163	9	because	because	SCONJ
admet-286	163	10	second	second	ADJ
admet-286	163	11	inoculum	inoculum	NOUN
admet-286	163	12	was	be	AUX
admet-286	163	13	added	add	VERB
admet-286	163	14	at	at	ADP
admet-286	163	15	this	this	DET
admet-286	163	16	time	time	NOUN
admet-286	163	17	point	point	NOUN
admet-286	163	18	which	which	PRON
admet-286	163	19	might	might	AUX
admet-286	163	20	affect	affect	VERB
admet-286	163	21	the	the	DET
admet-286	163	22	net	net	ADJ
admet-286	163	23	reduction	reduction	NOUN
admet-286	163	24	in	in	ADP
admet-286	163	25	bacterial	bacterial	ADJ
admet-286	163	26	density	density	NOUN
admet-286	163	27	.	.	PUNCT
admet-286	164	1	sigmoidal	sigmoidal	NOUN
admet-286	164	2	emax	emax	X
admet-286	164	3	type	type	NOUN
admet-286	164	4	function	function	NOUN
admet-286	164	5	(	(	PUNCT
admet-286	164	6	see	see	VERB
admet-286	164	7	materials	material	NOUN
admet-286	164	8	and	and	CCONJ
admet-286	164	9	methods	method	NOUN
admet-286	164	10	,	,	PUNCT
admet-286	164	11	equation	equation	NOUN
admet-286	164	12	2	2	NUM
admet-286	164	13	)	)	PUNCT
admet-286	164	14	was	be	AUX
admet-286	164	15	used	use	VERB
admet-286	164	16	for	for	ADP
admet-286	164	17	fitting	fit	VERB
admet-286	164	18	the	the	DET
admet-286	164	19	exposureresponse	exposureresponse	NOUN
admet-286	164	20	dat	dat	NOUN
admet-286	164	21	;	;	PUNCT
admet-286	164	22	and	and	CCONJ
admet-286	164	23	coefficient	coefficient	NOUN
admet-286	164	24	of	of	ADP
admet-286	164	25	correlation	correlation	NOUN
admet-286	164	26	(	(	PUNCT
admet-286	164	27	r2	r2	PROPN
admet-286	164	28	)	)	PUNCT
admet-286	164	29	,	,	PUNCT
admet-286	164	30	and	and	CCONJ
admet-286	164	31	sigmoidal	sigmoidal	NOUN
admet-286	164	32	factor	factor	NOUN
admet-286	164	33	(	(	PUNCT
admet-286	164	34	γ	γ	NOUN
admet-286	164	35	)	)	PUNCT
admet-286	164	36	were	be	AUX
admet-286	164	37	computed	compute	VERB
admet-286	164	38	.	.	PUNCT
admet-286	165	1	sigmoidal	sigmoidal	NOUN
admet-286	165	2	factor	factor	NOUN
admet-286	165	3	is	be	AUX
admet-286	165	4	the	the	DET
admet-286	165	5	steepness	steepness	NOUN
admet-286	165	6	of	of	ADP
admet-286	165	7	the	the	DET
admet-286	165	8	sigmoidal	sigmoidal	NOUN
admet-286	165	9	curve	curve	NOUN
admet-286	165	10	and	and	CCONJ
admet-286	165	11	can	can	AUX
admet-286	165	12	suggest	suggest	VERB
admet-286	165	13	the	the	DET
admet-286	165	14	predictability	predictability	NOUN
admet-286	165	15	of	of	ADP
admet-286	165	16	the	the	DET
admet-286	165	17	sigmodial	sigmodial	ADJ
admet-286	165	18	model	model	NOUN
admet-286	165	19	.	.	PUNCT
admet-286	166	1	for	for	ADP
admet-286	166	2	instance	instance	NOUN
admet-286	166	3	,	,	PUNCT
admet-286	166	4	when	when	SCONJ
admet-286	166	5	the	the	DET
admet-286	166	6	steepness	steepness	NOUN
admet-286	166	7	is	be	AUX
admet-286	166	8	high	high	ADJ
admet-286	166	9	,	,	PUNCT
admet-286	166	10	the	the	DET
admet-286	166	11	exposure	exposure	NOUN
admet-286	166	12	-	-	PUNCT
admet-286	166	13	response	response	NOUN
admet-286	166	14	relationship	relationship	NOUN
admet-286	166	15	becomes	become	VERB
admet-286	166	16	steep	steep	ADJ
admet-286	166	17	enough	enough	ADV
admet-286	166	18	for	for	ADP
admet-286	166	19	the	the	DET
admet-286	166	20	all	all	ADV
admet-286	166	21	-	-	PUNCT
admet-286	166	22	or	or	CCONJ
admet-286	166	23	-	-	PUNCT
admet-286	166	24	none	none	NOUN
admet-286	166	25	effect	effect	NOUN
admet-286	166	26	,	,	PUNCT
admet-286	166	27	which	which	PRON
admet-286	166	28	is	be	AUX
admet-286	166	29	not	not	PART
admet-286	166	30	desired	desire	VERB
admet-286	166	31	in	in	ADP
admet-286	166	32	identification	identification	NOUN
admet-286	166	33	of	of	ADP
admet-286	166	34	pk	pk	NOUN
admet-286	166	35	/	/	SYM
admet-286	166	36	pd	pd	NOUN
admet-286	166	37	drivers	driver	NOUN
admet-286	166	38	which	which	PRON
admet-286	166	39	is	be	AUX
admet-286	166	40	intended	intend	VERB
admet-286	166	41	to	to	PART
admet-286	166	42	correlate	correlate	VERB
admet-286	166	43	/	/	SYM
admet-286	166	44	simulate	simulate	VERB
admet-286	166	45	the	the	DET
admet-286	166	46	dose	dose	NOUN
admet-286	166	47	-	-	PUNCT
admet-286	166	48	dependent	dependent	ADJ
admet-286	166	49	sigmoidal	sigmoidal	NOUN
admet-286	166	50	drug	drug	NOUN
admet-286	166	51	effect	effect	NOUN
admet-286	166	52	.	.	PUNCT
admet-286	167	1	it	it	PRON
admet-286	167	2	must	must	AUX
admet-286	167	3	be	be	AUX
admet-286	167	4	noted	note	VERB
admet-286	167	5	that	that	SCONJ
admet-286	167	6	the	the	DET
admet-286	167	7	intial	intial	ADJ
admet-286	167	8	admet	admet	PROPN
admet-286	167	9	&	&	CCONJ
admet-286	167	10	dmpk	dmpk	PROPN
admet-286	167	11	4(3	4(3	NUM
admet-286	167	12	)	)	PUNCT
admet-286	167	13	(	(	PUNCT
admet-286	167	14	2016	2016	NUM
admet-286	167	15	)	)	PUNCT
admet-286	167	16	241	241	NUM
admet-286	167	17	-	-	SYM
admet-286	167	18	260	260	NUM
admet-286	167	19	dose	dose	NOUN
admet-286	167	20	optimization	optimization	NOUN
admet-286	167	21	of	of	ADP
admet-286	167	22	fdc	fdc	PROPN
admet-286	167	23	against	against	ADP
admet-286	167	24	s.	s.	PROPN
admet-286	167	25	aureus	aureus	PROPN
admet-286	167	26	resistant	resistant	ADJ
admet-286	167	27	bacteria	bacteria	NOUN
admet-286	167	28	doi	doi	NOUN
admet-286	167	29	:	:	PUNCT
admet-286	167	30	10.5599	10.5599	NUM
admet-286	167	31	/	/	SYM
admet-286	167	32	admet.4.3.286	admet.4.3.286	VERB
admet-286	167	33	249	249	NUM
admet-286	167	34	concentration	concentration	NOUN
admet-286	167	35	or	or	CCONJ
admet-286	167	36	cmax	cmax	NOUN
admet-286	167	37	is	be	AUX
admet-286	167	38	predecided	predecide	VERB
admet-286	167	39	when	when	SCONJ
admet-286	167	40	the	the	DET
admet-286	167	41	drug	drug	NOUN
admet-286	167	42	was	be	AUX
admet-286	167	43	injected	inject	VERB
admet-286	167	44	in	in	ADP
admet-286	167	45	in	in	ADP
admet-286	167	46	vitro	vitro	X
admet-286	167	47	system	system	NOUN
admet-286	167	48	,	,	PUNCT
admet-286	167	49	as	as	SCONJ
admet-286	167	50	shown	show	VERB
admet-286	167	51	by	by	ADP
admet-286	167	52	higher	high	ADJ
admet-286	167	53	coefficients	coefficient	NOUN
admet-286	167	54	of	of	ADP
admet-286	167	55	correlation	correlation	NOUN
admet-286	167	56	of	of	ADP
admet-286	167	57	log	log	NOUN
admet-286	167	58	cmax	cmax	NOUN
admet-286	167	59	vs	vs	ADP
admet-286	167	60	log	log	PROPN
admet-286	167	61	δcfus	δcfus	PROPN
admet-286	167	62	(	(	PUNCT
admet-286	167	63	figure	figure	NOUN
admet-286	167	64	4b	4b	PROPN
admet-286	167	65	)	)	PUNCT
admet-286	167	66	.	.	PUNCT
admet-286	168	1	thus	thus	ADV
admet-286	168	2	,	,	PUNCT
admet-286	168	3	cmax	cmax	NOUN
admet-286	168	4	curves	curve	NOUN
admet-286	168	5	were	be	AUX
admet-286	168	6	not	not	PART
admet-286	168	7	further	far	ADV
admet-286	168	8	used	use	VERB
admet-286	168	9	to	to	PART
admet-286	168	10	identify	identify	VERB
admet-286	168	11	the	the	DET
admet-286	168	12	pk	pk	PROPN
admet-286	168	13	/	/	SYM
admet-286	168	14	pd	pd	PROPN
admet-286	168	15	driver	driver	NOUN
admet-286	168	16	of	of	ADP
admet-286	168	17	the	the	DET
admet-286	168	18	current	current	ADJ
admet-286	168	19	fdc	fdc	PROPN
admet-286	168	20	.	.	PUNCT
admet-286	169	1	ceftriaxone	ceftriaxone	PROPN
admet-286	169	2	individually	individually	ADV
admet-286	169	3	(	(	PUNCT
admet-286	169	4	r2	r2	NOUN
admet-286	169	5	of	of	ADP
admet-286	169	6	0.82	0.82	NUM
admet-286	169	7	for	for	ADP
admet-286	169	8	%	%	NOUN
admet-286	169	9	t	t	PROPN
admet-286	169	10	>	>	X
admet-286	169	11	mic	mic	NOUN
admet-286	169	12	)	)	PUNCT
admet-286	169	13	showed	show	VERB
admet-286	169	14	the	the	DET
admet-286	169	15	time	time	NOUN
admet-286	169	16	-	-	PUNCT
admet-286	169	17	dependent	dependent	ADJ
admet-286	169	18	antibacterial	antibacterial	ADJ
admet-286	169	19	effect	effect	NOUN
admet-286	169	20	of	of	ADP
admet-286	169	21	the	the	DET
admet-286	169	22	drug	drug	NOUN
admet-286	169	23	,	,	PUNCT
admet-286	169	24	which	which	PRON
admet-286	169	25	also	also	ADV
admet-286	169	26	confirms	confirm	VERB
admet-286	169	27	with	with	ADP
admet-286	169	28	the	the	DET
admet-286	169	29	literature	literature	NOUN
admet-286	169	30	[	[	X
admet-286	169	31	35	35	NUM
admet-286	169	32	]	]	PUNCT
admet-286	169	33	(	(	PUNCT
admet-286	169	34	figure	figure	NOUN
admet-286	169	35	s1a	s1a	NOUN
admet-286	169	36	)	)	PUNCT
admet-286	169	37	.	.	PUNCT
admet-286	170	1	since	since	SCONJ
admet-286	170	2	,	,	PUNCT
admet-286	170	3	auc	auc	NOUN
admet-286	170	4	is	be	AUX
admet-286	170	5	directly	directly	ADV
admet-286	170	6	dependent	dependent	ADJ
admet-286	170	7	upon	upon	SCONJ
admet-286	170	8	the	the	DET
admet-286	170	9	drug	drug	NOUN
admet-286	170	10	concentration	concentration	NOUN
admet-286	170	11	and	and	CCONJ
admet-286	170	12	time	time	NOUN
admet-286	170	13	,	,	PUNCT
admet-286	170	14	auc	auc	NOUN
admet-286	170	15	/	/	SYM
admet-286	170	16	mic	mic	NOUN
admet-286	170	17	(	(	PUNCT
admet-286	170	18	r	r	NOUN
admet-286	170	19	2	2	NUM
admet-286	170	20	=	=	NOUN
admet-286	170	21	0.95	0.95	NUM
admet-286	170	22	)	)	PUNCT
admet-286	170	23	also	also	ADV
admet-286	170	24	showed	show	VERB
admet-286	170	25	good	good	ADJ
admet-286	170	26	correlation	correlation	NOUN
admet-286	170	27	with	with	ADP
admet-286	170	28	change	change	NOUN
admet-286	170	29	in	in	ADP
admet-286	170	30	bacterial	bacterial	ADJ
admet-286	170	31	density	density	NOUN
admet-286	170	32	(	(	PUNCT
admet-286	170	33	figure	figure	NOUN
admet-286	170	34	s1a	s1a	NOUN
admet-286	170	35	)	)	PUNCT
admet-286	170	36	.	.	PUNCT
admet-286	171	1	for	for	ADP
admet-286	171	2	vancomycin	vancomycin	PROPN
admet-286	171	3	,	,	PUNCT
admet-286	171	4	lower	low	ADJ
admet-286	171	5	r	r	NOUN
admet-286	171	6	2	2	NUM
admet-286	171	7	value	value	NOUN
admet-286	171	8	of	of	ADP
admet-286	171	9	0.38	0.38	NUM
admet-286	171	10	for	for	ADP
admet-286	171	11	%	%	NOUN
admet-286	171	12	t	t	PROPN
admet-286	171	13	>	>	X
admet-286	171	14	mic	mic	NOUN
admet-286	171	15	vs	vs	ADP
admet-286	171	16	log	log	NOUN
admet-286	171	17	δcfus	δcfus	PROPN
admet-286	171	18	and	and	CCONJ
admet-286	171	19	higher	high	ADJ
admet-286	171	20	r	r	NOUN
admet-286	171	21	2	2	NUM
admet-286	171	22	value	value	NOUN
admet-286	171	23	of	of	ADP
admet-286	171	24	0.97	0.97	NUM
admet-286	171	25	for	for	ADP
admet-286	171	26	log	log	NOUN
admet-286	171	27	auc	auc	NOUN
admet-286	171	28	/	/	SYM
admet-286	171	29	mic	mic	NOUN
admet-286	171	30	vs	vs	ADP
admet-286	171	31	log	log	PROPN
admet-286	171	32	δcfus	δcfus	PROPN
admet-286	171	33	suggest	suggest	VERB
admet-286	171	34	exposuredependent	exposuredependent	NOUN
admet-286	171	35	antibacterial	antibacterial	ADJ
admet-286	171	36	effect	effect	NOUN
admet-286	171	37	and	and	CCONJ
admet-286	171	38	this	this	PRON
admet-286	171	39	is	be	AUX
admet-286	171	40	in	in	ADP
admet-286	171	41	agreement	agreement	NOUN
admet-286	171	42	with	with	ADP
admet-286	171	43	the	the	DET
admet-286	171	44	literature	literature	NOUN
admet-286	171	45	(	(	PUNCT
admet-286	171	46	figure	figure	NOUN
admet-286	171	47	s1b	s1b	NOUN
admet-286	171	48	)	)	PUNCT
admet-286	171	49	[	[	X
admet-286	171	50	33	33	NUM
admet-286	171	51	,	,	PUNCT
admet-286	171	52	36	36	NUM
admet-286	171	53	-	-	SYM
admet-286	171	54	37	37	NUM
admet-286	171	55	]	]	PUNCT
admet-286	171	56	.	.	PUNCT
admet-286	172	1	figure	figure	NOUN
admet-286	172	2	4	4	NUM
admet-286	172	3	.	.	PUNCT
admet-286	173	1	the	the	DET
admet-286	173	2	pk	pk	PROPN
admet-286	173	3	/	/	SYM
admet-286	173	4	pd	pd	PROPN
admet-286	173	5	indices	index	NOUN
admet-286	173	6	i.e.	i.e.	X
admet-286	173	7	auccomb	auccomb	NOUN
admet-286	173	8	,	,	PUNCT
admet-286	173	9	cmax	cmax	NOUN
admet-286	173	10	-	-	PUNCT
admet-286	173	11	comb	comb	NOUN
admet-286	173	12	,	,	PUNCT
admet-286	173	13	%	%	INTJ
admet-286	173	14	t	t	X
admet-286	173	15	>	>	X
admet-286	173	16	miccomb	miccomb	PROPN
admet-286	173	17	and	and	CCONJ
admet-286	173	18	%	%	INTJ
admet-286	173	19	t	t	PROPN
admet-286	173	20	>	>	X
admet-286	173	21	fic	fic	NOUN
admet-286	173	22	were	be	AUX
admet-286	173	23	calculated	calculate	VERB
admet-286	173	24	for	for	ADP
admet-286	173	25	fdc	fdc	PROPN
admet-286	173	26	using	use	VERB
admet-286	173	27	ficcomb	ficcomb	ADJ
admet-286	173	28	curves	curve	NOUN
admet-286	173	29	.	.	PUNCT
admet-286	174	1	the	the	DET
admet-286	174	2	log	log	NOUN
admet-286	174	3	transformations	transformation	NOUN
admet-286	174	4	were	be	AUX
admet-286	174	5	done	do	VERB
admet-286	174	6	for	for	ADP
admet-286	174	7	auc	auc	NOUN
admet-286	174	8	/	/	SYM
admet-286	174	9	miccomb	miccomb	NOUN
admet-286	174	10	and	and	CCONJ
admet-286	174	11	cmax	cmax	NOUN
admet-286	174	12	-	-	PUNCT
admet-286	174	13	comb	comb	NOUN
admet-286	174	14	/	/	SYM
admet-286	174	15	mic	mic	NOUN
admet-286	174	16	.	.	PUNCT
admet-286	175	1	the	the	DET
admet-286	175	2	log	log	NOUN
admet-286	175	3	transformed	transform	VERB
admet-286	175	4	pk	pk	PROPN
admet-286	175	5	/	/	SYM
admet-286	175	6	pd	pd	PROPN
admet-286	175	7	indices	index	NOUN
admet-286	175	8	and	and	CCONJ
admet-286	175	9	%	%	INTJ
admet-286	175	10	t	t	PROPN
admet-286	175	11	>	>	X
admet-286	175	12	mic	mic	NOUN
admet-286	175	13	were	be	AUX
admet-286	175	14	plotted	plot	VERB
admet-286	175	15	against	against	ADP
admet-286	175	16	log	log	NOUN
admet-286	175	17	fold	fold	NOUN
admet-286	175	18	change	change	NOUN
admet-286	175	19	in	in	ADP
admet-286	175	20	bacterial	bacterial	ADJ
admet-286	175	21	density	density	NOUN
admet-286	175	22	.	.	PUNCT
admet-286	176	1	the	the	DET
admet-286	176	2	data	datum	NOUN
admet-286	176	3	was	be	AUX
admet-286	176	4	fitted	fit	VERB
admet-286	176	5	with	with	ADP
admet-286	176	6	a	a	DET
admet-286	176	7	sigmoidal	sigmoidal	NOUN
admet-286	176	8	emax	emax	NOUN
admet-286	176	9	type	type	NOUN
admet-286	176	10	function	function	NOUN
admet-286	176	11	.	.	PUNCT
admet-286	177	1	model	model	NOUN
admet-286	177	2	fitted	fit	VERB
admet-286	177	3	values	value	NOUN
admet-286	177	4	of	of	ADP
admet-286	177	5	fdc	fdc	PROPN
admet-286	177	6	’s	’s	PART
admet-286	177	7	pk	pk	PROPN
admet-286	177	8	/	/	SYM
admet-286	177	9	pd	pd	NOUN
admet-286	177	10	index	index	NOUN
admet-286	177	11	auccomb	auccomb	NOUN
admet-286	177	12	(	(	PUNCT
admet-286	177	13	a	a	X
admet-286	177	14	)	)	PUNCT
admet-286	177	15	,	,	PUNCT
admet-286	177	16	log	log	PROPN
admet-286	177	17	cmax	cmax	NOUN
admet-286	177	18	-	-	PUNCT
admet-286	177	19	comb	comb	NOUN
admet-286	177	20	(	(	PUNCT
admet-286	177	21	b	b	NOUN
admet-286	177	22	)	)	PUNCT
admet-286	177	23	,	,	PUNCT
admet-286	177	24	%	%	INTJ
admet-286	177	25	t	t	X
admet-286	177	26	>	>	X
admet-286	177	27	miccomb	miccomb	PROPN
admet-286	177	28	(	(	PUNCT
admet-286	177	29	c	c	NOUN
admet-286	177	30	)	)	PUNCT
admet-286	177	31	,	,	PUNCT
admet-286	177	32	and	and	CCONJ
admet-286	177	33	%	%	INTJ
admet-286	177	34	t	t	X
admet-286	177	35	>	>	X
admet-286	177	36	fic	fic	NOUN
admet-286	177	37	(	(	PUNCT
admet-286	177	38	d	d	NOUN
admet-286	177	39	)	)	PUNCT
admet-286	177	40	,	,	PUNCT
admet-286	177	41	and	and	CCONJ
admet-286	177	42	its	its	PRON
admet-286	177	43	relationship	relationship	NOUN
admet-286	177	44	with	with	ADP
admet-286	177	45	log	log	NOUN
admet-286	177	46	fold	fold	NOUN
admet-286	177	47	change	change	NOUN
admet-286	177	48	in	in	ADP
admet-286	177	49	bacterial	bacterial	ADJ
admet-286	177	50	density	density	NOUN
admet-286	177	51	were	be	AUX
admet-286	177	52	shown	show	VERB
admet-286	177	53	.	.	PUNCT
admet-286	178	1	since	since	SCONJ
admet-286	178	2	the	the	DET
admet-286	178	3	pk	pk	PROPN
admet-286	178	4	/	/	SYM
admet-286	178	5	pd	pd	PROPN
admet-286	178	6	driver	driver	NOUN
admet-286	178	7	of	of	ADP
admet-286	178	8	ceftriaxone	ceftriaxone	PROPN
admet-286	178	9	and	and	CCONJ
admet-286	178	10	vancomycin	vancomycin	PROPN
admet-286	178	11	were	be	AUX
admet-286	178	12	different	different	ADJ
admet-286	178	13	,	,	PUNCT
admet-286	178	14	fics	fic	NOUN
admet-286	178	15	were	be	AUX
admet-286	178	16	used	use	VERB
admet-286	178	17	in	in	ADP
admet-286	178	18	order	order	NOUN
admet-286	178	19	to	to	PART
admet-286	178	20	combine	combine	VERB
admet-286	178	21	the	the	DET
admet-286	178	22	contribution	contribution	NOUN
admet-286	178	23	of	of	ADP
admet-286	178	24	both	both	DET
admet-286	178	25	drugs	drug	NOUN
admet-286	178	26	as	as	ADP
admet-286	178	27	per	per	ADP
admet-286	178	28	their	their	PRON
admet-286	178	29	concentration	concentration	NOUN
admet-286	178	30	and	and	CCONJ
admet-286	178	31	mic	mic	ADJ
admet-286	178	32	contribution	contribution	NOUN
admet-286	178	33	in	in	ADP
admet-286	178	34	the	the	DET
admet-286	178	35	fdc	fdc	PROPN
admet-286	178	36	.	.	PUNCT
admet-286	179	1	the	the	DET
admet-286	179	2	objective	objective	NOUN
admet-286	179	3	was	be	AUX
admet-286	179	4	to	to	PART
admet-286	179	5	find	find	VERB
admet-286	179	6	the	the	DET
admet-286	179	7	pk	pk	NOUN
admet-286	179	8	/	/	SYM
admet-286	179	9	pd	pd	NOUN
admet-286	179	10	index	index	NOUN
admet-286	179	11	that	that	PRON
admet-286	179	12	can	can	AUX
admet-286	179	13	predict	predict	VERB
admet-286	179	14	the	the	DET
admet-286	179	15	antibacterial	antibacterial	ADJ
admet-286	179	16	effect	effect	NOUN
admet-286	179	17	of	of	ADP
admet-286	179	18	the	the	DET
admet-286	179	19	ceftriaxone	ceftriaxone	PROPN
admet-286	179	20	/	/	SYM
admet-286	179	21	vancomycin	vancomycin	PROPN
admet-286	179	22	(	(	PUNCT
admet-286	179	23	2/1	2/1	NUM
admet-286	179	24	)	)	PUNCT
admet-286	179	25	as	as	ADP
admet-286	179	26	a	a	DET
admet-286	179	27	single	single	ADJ
admet-286	179	28	unit	unit	NOUN
admet-286	179	29	.	.	PUNCT
admet-286	180	1	from	from	ADP
admet-286	180	2	fic	fic	ADJ
admet-286	180	3	-	-	PUNCT
admet-286	180	4	t	t	NOUN
admet-286	180	5	profiles	profile	NOUN
admet-286	180	6	,	,	PUNCT
admet-286	180	7	auccomb	auccomb	NOUN
admet-286	180	8	,	,	PUNCT
admet-286	180	9	cmax	cmax	NOUN
admet-286	180	10	-	-	PUNCT
admet-286	180	11	comb	comb	NOUN
admet-286	180	12	,	,	PUNCT
admet-286	180	13	%	%	INTJ
admet-286	180	14	t	t	X
admet-286	180	15	>	>	X
admet-286	180	16	miccomb	miccomb	PROPN
admet-286	180	17	,	,	PUNCT
admet-286	180	18	and	and	CCONJ
admet-286	180	19	%	%	INTJ
admet-286	180	20	t	t	PROPN
admet-286	180	21	>	>	X
admet-286	180	22	fic	fic	NOUN
admet-286	180	23	were	be	AUX
admet-286	180	24	calculated	calculate	VERB
admet-286	180	25	and	and	CCONJ
admet-286	180	26	plotted	plot	VERB
admet-286	180	27	against	against	ADP
admet-286	180	28	bacterial	bacterial	ADJ
admet-286	180	29	killing	killing	NOUN
admet-286	180	30	(	(	PUNCT
admet-286	180	31	figure	figure	NOUN
admet-286	180	32	4	4	NUM
admet-286	180	33	)	)	PUNCT
admet-286	180	34	.	.	PUNCT
admet-286	181	1	as	as	SCONJ
admet-286	181	2	shown	show	VERB
admet-286	181	3	in	in	ADP
admet-286	181	4	figure	figure	NOUN
admet-286	181	5	4c	4c	NOUN
admet-286	181	6	,	,	PUNCT
admet-286	181	7	the	the	DET
admet-286	181	8	r2	r2	NOUN
admet-286	181	9	is	be	AUX
admet-286	181	10	highest	high	ADJ
admet-286	181	11	for	for	ADP
admet-286	181	12	%	%	PROPN
admet-286	181	13	t	t	PROPN
admet-286	181	14	>	>	X
admet-286	181	15	miccomb	miccomb	PROPN
admet-286	181	16	i.e.	i.e.	X
admet-286	181	17	0.98	0.98	NUM
admet-286	181	18	with	with	ADP
admet-286	181	19	high	high	ADJ
admet-286	181	20	predictability	predictability	NOUN
admet-286	181	21	(	(	PUNCT
admet-286	181	22	γ	γ	X
admet-286	181	23	=	=	NOUN
admet-286	181	24	2.262	2.262	NUM
admet-286	181	25	)	)	PUNCT
admet-286	181	26	.	.	PUNCT
admet-286	182	1	the	the	DET
admet-286	182	2	second	second	ADJ
admet-286	182	3	best	good	ADJ
admet-286	182	4	r2	r2	NOUN
admet-286	182	5	of	of	ADP
admet-286	182	6	0.97	0.97	NUM
admet-286	182	7	was	be	AUX
admet-286	182	8	obtained	obtain	VERB
admet-286	182	9	from	from	ADP
admet-286	182	10	the	the	DET
admet-286	182	11	plot	plot	NOUN
admet-286	182	12	of	of	ADP
admet-286	182	13	log	log	NOUN
admet-286	182	14	auccomb	auccomb	NOUN
admet-286	182	15	vs	vs	ADP
admet-286	182	16	log	log	NOUN
admet-286	182	17	δcfu	δcfu	NOUN
admet-286	182	18	(	(	PUNCT
admet-286	182	19	γ	γ	X
admet-286	182	20	=	=	PROPN
admet-286	182	21	13.51	13.51	NUM
admet-286	182	22	;	;	PUNCT
admet-286	182	23	good	good	ADJ
admet-286	182	24	predictability	predictability	NOUN
admet-286	182	25	)	)	PUNCT
admet-286	182	26	(	(	PUNCT
admet-286	182	27	figure	figure	NOUN
admet-286	182	28	4a	4a	NUM
admet-286	182	29	)	)	PUNCT
admet-286	182	30	.	.	PUNCT
admet-286	183	1	for	for	ADP
admet-286	183	2	%	%	PROPN
admet-286	183	3	t	t	PROPN
admet-286	183	4	>	>	X
admet-286	183	5	fic	fic	PROPN
admet-286	183	6	,	,	PUNCT
admet-286	183	7	r2	r2	PROPN
admet-286	183	8	was	be	AUX
admet-286	183	9	0.97	0.97	NUM
admet-286	183	10	but	but	CCONJ
admet-286	183	11	γ	γ	NOUN
admet-286	183	12	was	be	AUX
admet-286	183	13	very	very	ADV
admet-286	183	14	high	high	ADJ
admet-286	183	15	at	at	ADP
admet-286	183	16	153.8	153.8	NUM
admet-286	183	17	(	(	PUNCT
admet-286	183	18	figure	figure	NOUN
admet-286	183	19	4d	4d	NUM
admet-286	183	20	)	)	PUNCT
admet-286	183	21	.	.	PUNCT
admet-286	184	1	high	high	ADJ
admet-286	184	2	value	value	NOUN
admet-286	184	3	of	of	ADP
admet-286	184	4	sigmoidicity	sigmoidicity	NOUN
admet-286	184	5	factor	factor	NOUN
admet-286	184	6	suggest	suggest	VERB
admet-286	184	7	all	all	ADV
admet-286	184	8	-	-	PUNCT
admet-286	184	9	or	or	CCONJ
admet-286	184	10	-	-	PUNCT
admet-286	184	11	none	none	NOUN
admet-286	184	12	function	function	NOUN
admet-286	184	13	of	of	ADP
admet-286	184	14	the	the	DET
admet-286	184	15	system	system	NOUN
admet-286	184	16	and	and	CCONJ
admet-286	184	17	thus	thus	ADV
admet-286	184	18	decrease	decrease	VERB
admet-286	184	19	the	the	DET
admet-286	184	20	predictability	predictability	NOUN
admet-286	184	21	of	of	ADP
admet-286	184	22	model	model	NOUN
admet-286	184	23	.	.	PUNCT
admet-286	185	1	therefore	therefore	ADV
admet-286	185	2	,	,	PUNCT
admet-286	185	3	%	%	INTJ
admet-286	185	4	t	t	PROPN
admet-286	185	5	>	>	X
admet-286	185	6	miccomb	miccomb	PROPN
admet-286	185	7	was	be	AUX
admet-286	185	8	considered	consider	VERB
admet-286	185	9	as	as	ADP
admet-286	185	10	a	a	DET
admet-286	185	11	best	good	ADJ
admet-286	185	12	pk	pk	NOUN
admet-286	185	13	/	/	SYM
admet-286	185	14	pd	pd	NOUN
admet-286	185	15	driver	driver	NOUN
admet-286	185	16	followed	follow	VERB
admet-286	185	17	by	by	ADP
admet-286	185	18	auccomb	auccomb	NOUN
admet-286	185	19	,	,	PUNCT
admet-286	185	20	to	to	PART
admet-286	185	21	predict	predict	VERB
admet-286	185	22	the	the	DET
admet-286	185	23	pd	pd	PROPN
admet-286	185	24	effect	effect	NOUN
admet-286	185	25	of	of	ADP
admet-286	185	26	ceftriaxone	ceftriaxone	PROPN
admet-286	185	27	/	/	SYM
admet-286	185	28	vancomycin	vancomycin	PROPN
admet-286	185	29	(	(	PUNCT
admet-286	185	30	2/1	2/1	NUM
admet-286	185	31	)	)	PUNCT
admet-286	185	32	in	in	ADP
admet-286	185	33	the	the	DET
admet-286	185	34	study	study	NOUN
admet-286	185	35	.	.	PUNCT
admet-286	186	1	vishnu	vishnu	PROPN
admet-286	186	2	sharma	sharma	PROPN
admet-286	186	3	et	et	PROPN
admet-286	186	4	al	al	PROPN
admet-286	186	5	.	.	PROPN
admet-286	186	6	admet	admet	PROPN
admet-286	186	7	&	&	CCONJ
admet-286	186	8	dmpk	dmpk	PROPN
admet-286	186	9	4(3	4(3	NUM
admet-286	186	10	)	)	PUNCT
admet-286	186	11	(	(	PUNCT
admet-286	186	12	2016	2016	NUM
admet-286	186	13	)	)	PUNCT
admet-286	186	14	241	241	NUM
admet-286	186	15	-	-	SYM
admet-286	186	16	260	260	NUM
admet-286	186	17	250	250	NUM
admet-286	186	18	probability	probability	NOUN
admet-286	186	19	target	target	NOUN
admet-286	186	20	attainment	attainment	ADJ
admet-286	186	21	levels	level	NOUN
admet-286	186	22	after	after	ADP
admet-286	186	23	selection	selection	NOUN
admet-286	186	24	of	of	ADP
admet-286	186	25	pk	pk	PROPN
admet-286	186	26	/	/	SYM
admet-286	186	27	pd	pd	NOUN
admet-286	186	28	driver	driver	NOUN
admet-286	186	29	(	(	PUNCT
admet-286	186	30	i.e.	i.e.	X
admet-286	186	31	%	%	NOUN
admet-286	186	32	t	t	PROPN
admet-286	186	33	>	>	X
admet-286	186	34	miccomb	miccomb	PROPN
admet-286	186	35	and	and	CCONJ
admet-286	186	36	auccomb	auccomb	NOUN
admet-286	186	37	)	)	PUNCT
admet-286	186	38	,	,	PUNCT
admet-286	186	39	the	the	DET
admet-286	186	40	next	next	ADJ
admet-286	186	41	objective	objective	NOUN
admet-286	186	42	was	be	AUX
admet-286	186	43	to	to	PART
admet-286	186	44	identify	identify	VERB
admet-286	186	45	a	a	DET
admet-286	186	46	desired	desire	VERB
admet-286	186	47	value	value	NOUN
admet-286	186	48	of	of	ADP
admet-286	186	49	%	%	NOUN
admet-286	186	50	t	t	PROPN
admet-286	186	51	>	>	X
admet-286	186	52	miccomb	miccomb	PROPN
admet-286	186	53	and	and	CCONJ
admet-286	186	54	auccomb	auccomb	VERB
admet-286	186	55	that	that	SCONJ
admet-286	186	56	one	one	PRON
admet-286	186	57	should	should	AUX
admet-286	186	58	target	target	VERB
admet-286	186	59	to	to	PART
admet-286	186	60	assure	assure	VERB
admet-286	186	61	good	good	ADJ
admet-286	186	62	therapeutic	therapeutic	ADJ
admet-286	186	63	effect	effect	NOUN
admet-286	186	64	of	of	ADP
admet-286	186	65	the	the	DET
admet-286	186	66	fdc	fdc	PROPN
admet-286	186	67	.	.	PUNCT
admet-286	187	1	thus	thus	ADV
admet-286	187	2	,	,	PUNCT
admet-286	187	3	plot	plot	NOUN
admet-286	187	4	of	of	ADP
admet-286	187	5	%	%	PROPN
admet-286	187	6	t	t	PROPN
admet-286	187	7	>	>	X
admet-286	187	8	mic	mic	NOUN
admet-286	187	9	vs.	vs.	ADP
admet-286	187	10	δ	δ	PROPN
admet-286	187	11	log10cfu	log10cfu	PROPN
admet-286	187	12	was	be	AUX
admet-286	187	13	evaluated	evaluate	VERB
admet-286	187	14	to	to	PART
admet-286	187	15	estimate	estimate	VERB
admet-286	187	16	desired	desire	VERB
admet-286	187	17	%	%	NOUN
admet-286	187	18	t	t	PROPN
admet-286	187	19	>	>	X
admet-286	187	20	mic	mic	ADJ
admet-286	187	21	value	value	NOUN
admet-286	187	22	(	(	PUNCT
admet-286	187	23	figure	figure	NOUN
admet-286	187	24	4c	4c	NOUN
admet-286	187	25	)	)	PUNCT
admet-286	187	26	.	.	PUNCT
admet-286	188	1	it	it	PRON
admet-286	188	2	was	be	AUX
admet-286	188	3	clearly	clearly	ADV
admet-286	188	4	observed	observe	VERB
admet-286	188	5	that	that	SCONJ
admet-286	188	6	pd	pd	ADJ
admet-286	188	7	effect	effect	NOUN
admet-286	188	8	of	of	ADP
admet-286	188	9	the	the	DET
admet-286	188	10	fdc	fdc	PROPN
admet-286	188	11	become	become	AUX
admet-286	188	12	saturated	saturated	ADJ
admet-286	188	13	after	after	ADP
admet-286	188	14	60	60	NUM
admet-286	188	15	%	%	NOUN
admet-286	188	16	t	t	X
admet-286	188	17	>	>	X
admet-286	188	18	mic	mic	NOUN
admet-286	188	19	,	,	PUNCT
admet-286	188	20	prompting	prompt	VERB
admet-286	188	21	us	we	PRON
admet-286	188	22	to	to	PART
admet-286	188	23	select	select	VERB
admet-286	188	24	60	60	NUM
admet-286	188	25	as	as	ADP
admet-286	188	26	a	a	DET
admet-286	188	27	target	target	NOUN
admet-286	188	28	value	value	NOUN
admet-286	188	29	of	of	ADP
admet-286	188	30	pk	pk	NOUN
admet-286	188	31	/	/	SYM
admet-286	188	32	pd	pd	X
admet-286	188	33	i.e.	i.e.	X
admet-286	188	34	%	%	PROPN
admet-286	188	35	t	t	PROPN
admet-286	188	36	>	>	X
admet-286	188	37	miccomb	miccomb	PROPN
admet-286	188	38	for	for	ADP
admet-286	188	39	dose	dose	NOUN
admet-286	188	40	optimization	optimization	NOUN
admet-286	188	41	.	.	PUNCT
admet-286	189	1	in	in	ADP
admet-286	189	2	other	other	ADJ
admet-286	189	3	words	word	NOUN
admet-286	189	4	,	,	PUNCT
admet-286	189	5	one	one	PRON
admet-286	189	6	can	can	AUX
admet-286	189	7	assure	assure	VERB
admet-286	189	8	good	good	ADJ
admet-286	189	9	therapeutic	therapeutic	ADJ
admet-286	189	10	effect	effect	NOUN
admet-286	189	11	of	of	ADP
admet-286	189	12	the	the	DET
admet-286	189	13	fdc	fdc	PROPN
admet-286	189	14	,	,	PUNCT
admet-286	189	15	if	if	SCONJ
admet-286	189	16	the	the	DET
admet-286	189	17	drug	drug	NOUN
admet-286	189	18	concentration	concentration	NOUN
admet-286	189	19	in	in	ADP
admet-286	189	20	body	body	NOUN
admet-286	189	21	remains	remain	VERB
admet-286	189	22	above	above	ADP
admet-286	189	23	mic	mic	NOUN
admet-286	189	24	for	for	ADP
admet-286	189	25	more	more	ADJ
admet-286	189	26	than	than	ADP
admet-286	189	27	60	60	NUM
admet-286	189	28	%	%	NOUN
admet-286	189	29	of	of	ADP
admet-286	189	30	time	time	NOUN
admet-286	189	31	of	of	ADP
admet-286	189	32	drug	drug	NOUN
admet-286	189	33	exposure	exposure	NOUN
admet-286	189	34	.	.	PUNCT
admet-286	190	1	using	use	VERB
admet-286	190	2	the	the	DET
admet-286	190	3	same	same	ADJ
admet-286	190	4	rationale	rationale	NOUN
admet-286	190	5	and	and	CCONJ
admet-286	190	6	figure	figure	NOUN
admet-286	190	7	4a	4a	NOUN
admet-286	190	8	,	,	PUNCT
admet-286	190	9	the	the	DET
admet-286	190	10	target	target	NOUN
admet-286	190	11	value	value	NOUN
admet-286	190	12	of	of	ADP
admet-286	190	13	400	400	NUM
admet-286	190	14	(	(	PUNCT
admet-286	190	15	~antilog	~antilog	X
admet-286	190	16	of	of	ADP
admet-286	190	17	2.6	2.6	NUM
admet-286	190	18	)	)	PUNCT
admet-286	190	19	was	be	AUX
admet-286	190	20	used	use	VERB
admet-286	190	21	for	for	ADP
admet-286	190	22	the	the	DET
admet-286	190	23	second	second	ADJ
admet-286	190	24	best	good	ADJ
admet-286	190	25	pk	pk	PROPN
admet-286	190	26	/	/	SYM
admet-286	190	27	pd	pd	NOUN
admet-286	190	28	driver	driver	NOUN
admet-286	190	29	i.e.	i.e.	X
admet-286	190	30	auccomb	auccomb	NOUN
admet-286	190	31	.	.	PUNCT
admet-286	191	1	dose	dose	NOUN
admet-286	191	2	optimization	optimization	NOUN
admet-286	191	3	and	and	CCONJ
admet-286	191	4	recommendation	recommendation	VERB
admet-286	191	5	the	the	DET
admet-286	191	6	pk	pk	NOUN
admet-286	191	7	/	/	SYM
admet-286	191	8	pd	pd	NOUN
admet-286	191	9	drivers	driver	NOUN
admet-286	191	10	of	of	ADP
admet-286	191	11	fdc	fdc	PROPN
admet-286	191	12	and	and	CCONJ
admet-286	191	13	its	its	PRON
admet-286	191	14	desired	desire	VERB
admet-286	191	15	values	value	NOUN
admet-286	191	16	were	be	AUX
admet-286	191	17	further	far	ADV
admet-286	191	18	utilized	utilize	VERB
admet-286	191	19	for	for	ADP
admet-286	191	20	dose	dose	NOUN
admet-286	191	21	optimization	optimization	NOUN
admet-286	191	22	and	and	CCONJ
admet-286	191	23	recommendation	recommendation	NOUN
admet-286	191	24	using	use	VERB
admet-286	191	25	three	three	NUM
admet-286	191	26	approaches	approach	NOUN
admet-286	191	27	i.e.	i.e.	X
admet-286	191	28	in	in	ADP
admet-286	191	29	vitro	vitro	X
admet-286	191	30	approach	approach	NOUN
admet-286	191	31	,	,	PUNCT
admet-286	191	32	pk	pk	NOUN
admet-286	191	33	/	/	SYM
admet-286	191	34	pd	pd	NOUN
admet-286	191	35	modeling	modeling	NOUN
admet-286	191	36	and	and	CCONJ
admet-286	191	37	monte	monte	PROPN
admet-286	191	38	carlo	carlo	PROPN
admet-286	191	39	simulations	simulation	NOUN
admet-286	191	40	.	.	PUNCT
admet-286	192	1	these	these	DET
admet-286	192	2	approaches	approach	NOUN
admet-286	192	3	use	use	VERB
admet-286	192	4	same	same	ADJ
admet-286	192	5	piece	piece	NOUN
admet-286	192	6	of	of	ADP
admet-286	192	7	information	information	NOUN
admet-286	192	8	and	and	CCONJ
admet-286	192	9	provide	provide	VERB
admet-286	192	10	inferential	inferential	ADJ
admet-286	192	11	data	datum	NOUN
admet-286	192	12	for	for	ADP
admet-286	192	13	dose	dose	NOUN
admet-286	192	14	optimization	optimization	NOUN
admet-286	192	15	which	which	PRON
admet-286	192	16	vary	vary	VERB
admet-286	192	17	from	from	ADP
admet-286	192	18	each	each	DET
admet-286	192	19	other	other	ADJ
admet-286	192	20	in	in	ADP
admet-286	192	21	terms	term	NOUN
admet-286	192	22	of	of	ADP
admet-286	192	23	specificity	specificity	NOUN
admet-286	192	24	of	of	ADP
admet-286	192	25	information	information	NOUN
admet-286	192	26	.	.	PUNCT
admet-286	193	1	the	the	DET
admet-286	193	2	first	first	ADJ
admet-286	193	3	approach	approach	NOUN
admet-286	193	4	(	(	PUNCT
admet-286	193	5	in	in	ADP
admet-286	193	6	vitro	vitro	X
admet-286	193	7	system	system	NOUN
admet-286	193	8	)	)	PUNCT
admet-286	193	9	mainly	mainly	ADV
admet-286	193	10	tells	tell	VERB
admet-286	193	11	about	about	ADP
admet-286	193	12	the	the	DET
admet-286	193	13	antibacterial	antibacterial	ADJ
admet-286	193	14	potential	potential	NOUN
admet-286	193	15	of	of	ADP
admet-286	193	16	the	the	DET
admet-286	193	17	fdc	fdc	PROPN
admet-286	193	18	under	under	ADP
admet-286	193	19	a	a	DET
admet-286	193	20	specific	specific	ADJ
admet-286	193	21	mic	mic	NOUN
admet-286	193	22	.	.	PUNCT
admet-286	194	1	the	the	DET
admet-286	194	2	pk	pk	PROPN
admet-286	194	3	/	/	SYM
admet-286	194	4	pd	pd	NOUN
admet-286	194	5	model	model	NOUN
admet-286	194	6	is	be	AUX
admet-286	194	7	generally	generally	ADV
admet-286	194	8	employed	employ	VERB
admet-286	194	9	for	for	ADP
admet-286	194	10	dose	dose	NOUN
admet-286	194	11	individualization	individualization	NOUN
admet-286	194	12	;	;	PUNCT
admet-286	194	13	whereas	whereas	ADV
admet-286	194	14	,	,	PUNCT
admet-286	194	15	monte	monte	PROPN
admet-286	194	16	carlo	carlo	PROPN
admet-286	194	17	simulations	simulation	NOUN
admet-286	194	18	broadly	broadly	ADV
admet-286	194	19	recommends	recommend	VERB
admet-286	194	20	dose	dose	NOUN
admet-286	194	21	regimen	regiman	NOUN
admet-286	194	22	based	base	VERB
admet-286	194	23	on	on	ADP
admet-286	194	24	mic	mic	NOUN
admet-286	194	25	of	of	ADP
admet-286	194	26	the	the	DET
admet-286	194	27	target	target	NOUN
admet-286	194	28	infection	infection	NOUN
admet-286	194	29	.	.	PUNCT
admet-286	195	1	all	all	DET
admet-286	195	2	three	three	NUM
admet-286	195	3	approaches	approach	NOUN
admet-286	195	4	were	be	AUX
admet-286	195	5	utilized	utilize	VERB
admet-286	195	6	to	to	PART
admet-286	195	7	understand	understand	VERB
admet-286	195	8	the	the	DET
admet-286	195	9	holistic	holistic	ADJ
admet-286	195	10	view	view	NOUN
admet-286	195	11	and	and	CCONJ
admet-286	195	12	are	be	AUX
admet-286	195	13	explained	explain	VERB
admet-286	195	14	below	below	ADV
admet-286	195	15	in	in	ADP
admet-286	195	16	detail	detail	NOUN
admet-286	195	17	.	.	PUNCT
admet-286	196	1	dosage	dosage	NOUN
admet-286	196	2	optimization	optimization	NOUN
admet-286	196	3	using	use	VERB
admet-286	196	4	in	in	ADP
admet-286	196	5	vitro	vitro	X
admet-286	196	6	system	system	NOUN
admet-286	196	7	:	:	PUNCT
admet-286	196	8	the	the	DET
admet-286	196	9	pd	pd	PROPN
admet-286	196	10	effect	effect	NOUN
admet-286	196	11	being	be	AUX
admet-286	196	12	driven	drive	VERB
admet-286	196	13	by	by	ADP
admet-286	196	14	the	the	DET
admet-286	196	15	time	time	NOUN
admet-286	196	16	-	-	PUNCT
admet-286	196	17	dependence	dependence	NOUN
admet-286	196	18	of	of	ADP
admet-286	196	19	fdc	fdc	PROPN
admet-286	196	20	,	,	PUNCT
admet-286	196	21	encouraged	encourage	VERB
admet-286	196	22	us	we	PRON
admet-286	196	23	to	to	PART
admet-286	196	24	fractionate	fractionate	VERB
admet-286	196	25	the	the	DET
admet-286	196	26	dose	dose	NOUN
admet-286	196	27	,	,	PUNCT
admet-286	196	28	with	with	ADP
admet-286	196	29	an	an	DET
admet-286	196	30	objective	objective	NOUN
admet-286	196	31	to	to	PART
admet-286	196	32	increase	increase	VERB
admet-286	196	33	the	the	DET
admet-286	196	34	duration	duration	NOUN
admet-286	196	35	of	of	ADP
admet-286	196	36	exposure	exposure	NOUN
admet-286	196	37	(	(	PUNCT
admet-286	196	38	above	above	ADP
admet-286	196	39	mic	mic	NOUN
admet-286	196	40	)	)	PUNCT
admet-286	196	41	and	and	CCONJ
admet-286	196	42	decrease	decrease	VERB
admet-286	196	43	the	the	DET
admet-286	196	44	overall	overall	ADJ
admet-286	196	45	concentration	concentration	NOUN
admet-286	196	46	(	(	PUNCT
admet-286	196	47	to	to	PART
admet-286	196	48	reduce	reduce	VERB
admet-286	196	49	side	side	NOUN
admet-286	196	50	effects	effect	NOUN
admet-286	196	51	)	)	PUNCT
admet-286	196	52	.	.	PUNCT
admet-286	197	1	for	for	ADP
admet-286	197	2	dose	dose	NOUN
admet-286	197	3	fractionation	fractionation	NOUN
admet-286	197	4	studies	study	NOUN
admet-286	197	5	,	,	PUNCT
admet-286	197	6	dose	dose	NOUN
admet-286	197	7	exposure	exposure	NOUN
admet-286	197	8	of	of	ADP
admet-286	197	9	50x	50x	NOUN
admet-286	197	10	mic	mic	ADJ
admet-286	197	11	i.e.	i.e.	X
admet-286	197	12	133.5/66.75	133.5/66.75	NUM
admet-286	197	13	µg	µg	NOUN
admet-286	197	14	/	/	SYM
admet-286	197	15	ml	ml	PROPN
admet-286	197	16	(	(	PUNCT
admet-286	197	17	ceftriaxone	ceftriaxone	PROPN
admet-286	197	18	/	/	SYM
admet-286	197	19	vancomycin	vancomycin	PROPN
admet-286	197	20	)	)	PUNCT
admet-286	197	21	was	be	AUX
admet-286	197	22	selected	select	VERB
admet-286	197	23	.	.	PUNCT
admet-286	198	1	considering	consider	VERB
admet-286	198	2	the	the	DET
admet-286	198	3	antibiotic	antibiotic	ADJ
admet-286	198	4	half	half	ADJ
admet-286	198	5	-	-	PUNCT
admet-286	198	6	life	life	NOUN
admet-286	198	7	and	and	CCONJ
admet-286	198	8	mic	mic	NOUN
admet-286	198	9	of	of	ADP
admet-286	198	10	drug	drug	NOUN
admet-286	198	11	against	against	ADP
admet-286	198	12	mrsa	mrsa	NOUN
admet-286	198	13	strains	strain	VERB
admet-286	198	14	,	,	PUNCT
admet-286	198	15	the	the	DET
admet-286	198	16	dose	dose	NOUN
admet-286	198	17	was	be	AUX
admet-286	198	18	fractionated	fractionate	VERB
admet-286	198	19	to	to	PART
admet-286	198	20	mimic	mimic	VERB
admet-286	198	21	a	a	DET
admet-286	198	22	dosage	dosage	NOUN
admet-286	198	23	regimen	regiman	NOUN
admet-286	198	24	of	of	ADP
admet-286	198	25	once	once	ADV
admet-286	198	26	-	-	PUNCT
admet-286	198	27	a	a	DET
admet-286	198	28	-	-	PUNCT
admet-286	198	29	day	day	NOUN
admet-286	198	30	,	,	PUNCT
admet-286	198	31	twice	twice	DET
admet-286	198	32	-	-	PUNCT
admet-286	198	33	a	a	DET
admet-286	198	34	-	-	PUNCT
admet-286	198	35	day	day	NOUN
admet-286	198	36	,	,	PUNCT
admet-286	198	37	and	and	CCONJ
admet-286	198	38	thrice	thrice	NOUN
admet-286	198	39	-	-	PUNCT
admet-286	198	40	a	a	DET
admet-286	198	41	-	-	PUNCT
admet-286	198	42	day	day	NOUN
admet-286	198	43	(	(	PUNCT
admet-286	198	44	figure	figure	NOUN
admet-286	198	45	5	5	NUM
admet-286	198	46	)	)	PUNCT
admet-286	198	47	.	.	PUNCT
admet-286	199	1	similar	similar	ADJ
admet-286	199	2	to	to	PART
admet-286	199	3	dose	dose	VERB
admet-286	199	4	escalation	escalation	NOUN
admet-286	199	5	study	study	NOUN
admet-286	199	6	,	,	PUNCT
admet-286	199	7	the	the	DET
admet-286	199	8	in	in	X
admet-286	199	9	vitro	vitro	X
admet-286	199	10	system	system	NOUN
admet-286	199	11	was	be	AUX
admet-286	199	12	used	use	VERB
admet-286	199	13	for	for	ADP
admet-286	199	14	these	these	DET
admet-286	199	15	dosage	dosage	NOUN
admet-286	199	16	regimens	regimen	NOUN
admet-286	199	17	and	and	CCONJ
admet-286	199	18	results	result	NOUN
admet-286	199	19	are	be	AUX
admet-286	199	20	shown	show	VERB
admet-286	199	21	in	in	ADP
admet-286	199	22	figure	figure	NOUN
admet-286	199	23	5	5	NUM
admet-286	199	24	and	and	CCONJ
admet-286	199	25	table	table	NOUN
admet-286	199	26	s1	s1	NOUN
admet-286	199	27	.	.	PUNCT
admet-286	200	1	the	the	DET
admet-286	200	2	antibacterial	antibacterial	ADJ
admet-286	200	3	effect	effect	NOUN
admet-286	200	4	of	of	ADP
admet-286	200	5	the	the	DET
admet-286	200	6	fdc	fdc	PROPN
admet-286	200	7	was	be	AUX
admet-286	200	8	increased	increase	VERB
admet-286	200	9	from	from	ADP
admet-286	200	10	once	once	ADV
admet-286	200	11	-	-	PUNCT
admet-286	200	12	a	a	DET
admet-286	200	13	day	day	NOUN
admet-286	200	14	dosing	dose	VERB
admet-286	200	15	to	to	ADP
admet-286	200	16	twice	twice	ADV
admet-286	200	17	-	-	PUNCT
admet-286	200	18	a	a	DET
admet-286	200	19	-	-	PUNCT
admet-286	200	20	day	day	NOUN
admet-286	200	21	dosage	dosage	NOUN
admet-286	200	22	regimen	regiman	NOUN
admet-286	200	23	in	in	ADP
admet-286	200	24	24	24	NUM
admet-286	200	25	hr	hr	NOUN
admet-286	200	26	time	time	NOUN
admet-286	200	27	period	period	NOUN
admet-286	200	28	(	(	PUNCT
admet-286	200	29	4.058	4.058	NUM
admet-286	200	30	fold	fold	NOUN
admet-286	200	31	to	to	ADP
admet-286	200	32	5.550	5.550	NUM
admet-286	200	33	fold	fold	ADJ
admet-286	200	34	reduction	reduction	NOUN
admet-286	200	35	in	in	ADP
admet-286	200	36	bacterial	bacterial	ADJ
admet-286	200	37	density	density	NOUN
admet-286	200	38	)	)	PUNCT
admet-286	200	39	.	.	PUNCT
admet-286	201	1	further	further	ADJ
admet-286	201	2	fractionation	fractionation	NOUN
admet-286	201	3	of	of	ADP
admet-286	201	4	dose	dose	NOUN
admet-286	201	5	in	in	ADP
admet-286	201	6	thrice	thrice	NOUN
admet-286	201	7	-	-	PUNCT
admet-286	201	8	a	a	DET
admet-286	201	9	-	-	PUNCT
admet-286	201	10	day	day	NOUN
admet-286	201	11	dosing	dosing	NOUN
admet-286	201	12	decreased	decrease	VERB
admet-286	201	13	the	the	DET
admet-286	201	14	drug	drug	NOUN
admet-286	201	15	concentration	concentration	NOUN
admet-286	201	16	below	below	ADP
admet-286	201	17	mic	mic	NOUN
admet-286	201	18	for	for	ADP
admet-286	201	19	longer	long	ADJ
admet-286	201	20	time	time	NOUN
admet-286	201	21	period	period	NOUN
admet-286	201	22	resulting	result	VERB
admet-286	201	23	in	in	ADP
admet-286	201	24	reduced	reduced	ADJ
admet-286	201	25	‘	'	PUNCT
admet-286	201	26	effective	effective	ADJ
admet-286	201	27	’	'	PUNCT
admet-286	201	28	exposure	exposure	NOUN
admet-286	201	29	time	time	NOUN
admet-286	201	30	i.e.	i.e.	X
admet-286	201	31	%	%	NOUN
admet-286	201	32	t	t	X
admet-286	201	33	>	>	X
admet-286	201	34	mic	mic	NOUN
admet-286	201	35	and	and	CCONJ
admet-286	201	36	translated	translate	VERB
admet-286	201	37	into	into	ADP
admet-286	201	38	sub	sub	ADJ
admet-286	201	39	-	-	ADJ
admet-286	201	40	optimal	optimal	ADJ
admet-286	201	41	2.32	2.32	NUM
admet-286	201	42	fold	fold	ADJ
admet-286	201	43	reduction	reduction	NOUN
admet-286	201	44	in	in	ADP
admet-286	201	45	bacterial	bacterial	ADJ
admet-286	201	46	density	density	NOUN
admet-286	201	47	.	.	PUNCT
admet-286	202	1	the	the	DET
admet-286	202	2	selected	select	VERB
admet-286	202	3	dosage	dosage	NOUN
admet-286	202	4	regimen	regiman	NOUN
admet-286	202	5	roughly	roughly	ADV
admet-286	202	6	corresponds	correspond	VERB
admet-286	202	7	to	to	ADP
admet-286	202	8	3	3	NUM
admet-286	202	9	g	g	PROPN
admet-286	202	10	fdc	fdc	PROPN
admet-286	202	11	of	of	ADP
admet-286	202	12	ceftriaxone	ceftriaxone	PROPN
admet-286	202	13	(	(	PUNCT
admet-286	202	14	2	2	NUM
admet-286	202	15	g	g	NOUN
admet-286	202	16	)	)	PUNCT
admet-286	202	17	and	and	CCONJ
admet-286	202	18	vancomycin	vancomycin	PROPN
admet-286	202	19	(	(	PUNCT
admet-286	202	20	1	1	NUM
admet-286	202	21	g	g	NOUN
admet-286	202	22	)	)	PUNCT
admet-286	202	23	,	,	PUNCT
admet-286	202	24	after	after	ADP
admet-286	202	25	correcting	correct	VERB
admet-286	202	26	for	for	ADP
admet-286	202	27	protein	protein	NOUN
admet-286	202	28	binding	bind	VERB
admet-286	202	29	of	of	ADP
admet-286	202	30	80	80	NUM
admet-286	202	31	and	and	CCONJ
admet-286	202	32	40	40	NUM
admet-286	202	33	%	%	NOUN
admet-286	202	34	;	;	PUNCT
admet-286	202	35	and	and	CCONJ
admet-286	202	36	volume	volume	NOUN
admet-286	202	37	of	of	ADP
admet-286	202	38	distribution	distribution	NOUN
admet-286	202	39	of	of	ADP
admet-286	202	40	10.1	10.1	NUM
admet-286	202	41	l	l	NOUN
admet-286	202	42	and	and	CCONJ
admet-286	202	43	25.8	25.8	NUM
admet-286	202	44	l	l	NOUN
admet-286	202	45	of	of	ADP
admet-286	202	46	both	both	DET
admet-286	202	47	components	component	NOUN
admet-286	202	48	i.e.	i.e.	X
admet-286	202	49	ceftriaxone	ceftriaxone	PROPN
admet-286	202	50	and	and	CCONJ
admet-286	202	51	vancomycin	vancomycin	PROPN
admet-286	202	52	respectively	respectively	ADV
admet-286	202	53	was	be	AUX
admet-286	202	54	observed	observe	VERB
admet-286	202	55	(	(	PUNCT
admet-286	202	56	table	table	NOUN
admet-286	202	57	1	1	NUM
admet-286	202	58	)	)	PUNCT
admet-286	202	59	.	.	PUNCT
admet-286	203	1	the	the	DET
admet-286	203	2	mic	mic	ADJ
admet-286	203	3	values	value	NOUN
admet-286	203	4	remained	remain	VERB
admet-286	203	5	same	same	ADJ
admet-286	203	6	during	during	ADP
admet-286	203	7	24	24	NUM
admet-286	203	8	h	h	NOUN
admet-286	203	9	drug	drug	NOUN
admet-286	203	10	-	-	PUNCT
admet-286	203	11	bacterial	bacterial	ADJ
admet-286	203	12	incubation	incubation	NOUN
admet-286	203	13	period	period	NOUN
admet-286	203	14	for	for	ADP
admet-286	203	15	all	all	DET
admet-286	203	16	drug	drug	NOUN
admet-286	203	17	exposures	exposure	NOUN
admet-286	203	18	(	(	PUNCT
admet-286	203	19	data	datum	NOUN
admet-286	203	20	not	not	PART
admet-286	203	21	shown	show	VERB
admet-286	203	22	)	)	PUNCT
admet-286	203	23	,	,	PUNCT
admet-286	203	24	thus	thus	ADV
admet-286	203	25	ruling	rule	VERB
admet-286	203	26	out	out	ADP
admet-286	203	27	the	the	DET
admet-286	203	28	possibility	possibility	NOUN
admet-286	203	29	of	of	ADP
admet-286	203	30	antimicrobial	antimicrobial	ADJ
admet-286	203	31	resistance	resistance	NOUN
admet-286	203	32	development	development	NOUN
admet-286	203	33	in	in	ADP
admet-286	203	34	mrsa	mrsa	NOUN
admet-286	203	35	isolates	isolate	NOUN
admet-286	203	36	during	during	ADP
admet-286	203	37	in	in	ADP
admet-286	203	38	vitro	vitro	X
admet-286	203	39	studies	study	NOUN
admet-286	203	40	.	.	PUNCT
admet-286	204	1	admet	admet	PROPN
admet-286	204	2	&	&	CCONJ
admet-286	204	3	dmpk	dmpk	PROPN
admet-286	204	4	4(3	4(3	NUM
admet-286	204	5	)	)	PUNCT
admet-286	204	6	(	(	PUNCT
admet-286	204	7	2016	2016	NUM
admet-286	204	8	)	)	PUNCT
admet-286	204	9	241	241	NUM
admet-286	204	10	-	-	SYM
admet-286	204	11	260	260	NUM
admet-286	204	12	dose	dose	NOUN
admet-286	204	13	optimization	optimization	NOUN
admet-286	204	14	of	of	ADP
admet-286	204	15	fdc	fdc	PROPN
admet-286	204	16	against	against	ADP
admet-286	204	17	s.	s.	PROPN
admet-286	204	18	aureus	aureus	PROPN
admet-286	204	19	resistant	resistant	ADJ
admet-286	204	20	bacteria	bacteria	NOUN
admet-286	204	21	doi	doi	NOUN
admet-286	204	22	:	:	PUNCT
admet-286	204	23	10.5599	10.5599	NUM
admet-286	204	24	/	/	SYM
admet-286	204	25	admet.4.3.286	admet.4.3.286	ADJ
admet-286	204	26	251	251	NUM
admet-286	204	27	figure	figure	NOUN
admet-286	204	28	5	5	NUM
admet-286	204	29	.	.	PUNCT
admet-286	204	30	selected	select	VERB
admet-286	204	31	50	50	NUM
admet-286	204	32	fold	fold	ADJ
admet-286	204	33	mic	mic	ADJ
admet-286	204	34	concentrations	concentration	NOUN
admet-286	204	35	of	of	ADP
admet-286	204	36	the	the	DET
admet-286	204	37	fixed	fix	VERB
admet-286	204	38	dose	dose	NOUN
admet-286	204	39	combination	combination	NOUN
admet-286	204	40	of	of	ADP
admet-286	204	41	ceftriaxone	ceftriaxone	NOUN
admet-286	204	42	/	/	SYM
admet-286	204	43	sulbactam	sulbactam	NOUN
admet-286	204	44	(	(	PUNCT
admet-286	204	45	2/1	2/1	NUM
admet-286	204	46	)	)	PUNCT
admet-286	204	47	were	be	AUX
admet-286	204	48	fractioned	fraction	VERB
admet-286	204	49	into	into	ADP
admet-286	204	50	once	once	ADV
admet-286	204	51	-	-	PUNCT
admet-286	204	52	a	a	DET
admet-286	204	53	-	-	PUNCT
admet-286	204	54	day	day	NOUN
admet-286	204	55	(	(	PUNCT
admet-286	204	56	od	od	NOUN
admet-286	204	57	)	)	PUNCT
admet-286	204	58	,	,	PUNCT
admet-286	204	59	twice	twice	DET
admet-286	204	60	-	-	PUNCT
admet-286	204	61	a	a	DET
admet-286	204	62	-	-	PUNCT
admet-286	204	63	day	day	NOUN
admet-286	204	64	(	(	PUNCT
admet-286	204	65	bd	bd	PROPN
admet-286	204	66	)	)	PUNCT
admet-286	204	67	and	and	CCONJ
admet-286	204	68	thrice	thrice	PROPN
admet-286	204	69	-	-	PUNCT
admet-286	204	70	a	a	DET
admet-286	204	71	-	-	PUNCT
admet-286	204	72	day	day	NOUN
admet-286	204	73	(	(	PUNCT
admet-286	204	74	tid	tid	NOUN
admet-286	204	75	)	)	PUNCT
admet-286	204	76	dosage	dosage	NOUN
admet-286	204	77	regimens	regimen	NOUN
admet-286	204	78	,	,	PUNCT
admet-286	204	79	and	and	CCONJ
admet-286	204	80	were	be	AUX
admet-286	204	81	plotted	plot	VERB
admet-286	204	82	against	against	ADP
admet-286	204	83	log	log	NOUN
admet-286	204	84	fold	fold	NOUN
admet-286	204	85	change	change	NOUN
admet-286	204	86	in	in	ADP
admet-286	204	87	bacterial	bacterial	ADJ
admet-286	204	88	density	density	NOUN
admet-286	204	89	(	(	PUNCT
admet-286	204	90	cfu	cfu	NOUN
admet-286	204	91	)	)	PUNCT
admet-286	204	92	.	.	PUNCT
admet-286	205	1	dosage	dosage	NOUN
admet-286	205	2	optimization	optimization	NOUN
admet-286	205	3	using	use	VERB
admet-286	205	4	pk	pk	PROPN
admet-286	205	5	/	/	SYM
admet-286	205	6	pd	pd	NOUN
admet-286	205	7	modeling	modeling	NOUN
admet-286	205	8	:	:	PUNCT
admet-286	205	9	pk	pk	PROPN
admet-286	205	10	/	/	SYM
admet-286	205	11	pd	pd	PROPN
admet-286	205	12	model	model	PROPN
admet-286	205	13	development	development	PROPN
admet-286	205	14	:	:	PUNCT
admet-286	205	15	the	the	DET
admet-286	205	16	pk	pk	PROPN
admet-286	205	17	/	/	SYM
admet-286	205	18	pd	pd	NOUN
admet-286	205	19	model	model	NOUN
admet-286	205	20	was	be	AUX
admet-286	205	21	developed	develop	VERB
admet-286	205	22	using	use	VERB
admet-286	205	23	equation	equation	NOUN
admet-286	205	24	3	3	NUM
admet-286	205	25	of	of	ADP
admet-286	205	26	sub	sub	ADJ
admet-286	205	27	-	-	ADJ
admet-286	205	28	section	section	ADJ
admet-286	205	29	section	section	NOUN
admet-286	205	30	'	'	PUNCT
admet-286	205	31	antibacterial	antibacterial	ADJ
admet-286	205	32	-	-	PUNCT
admet-286	205	33	pk	pk	NOUN
admet-286	205	34	/	/	SYM
admet-286	205	35	pd	pd	NOUN
admet-286	205	36	modeling	modeling	NOUN
admet-286	205	37	'	'	PUNCT
admet-286	205	38	under	under	ADP
admet-286	205	39	'	'	PUNCT
admet-286	205	40	materials	material	NOUN
admet-286	205	41	and	and	CCONJ
admet-286	205	42	method	method	NOUN
admet-286	205	43	'	'	PUNCT
admet-286	205	44	section	section	NOUN
admet-286	205	45	.	.	PUNCT
admet-286	206	1	the	the	DET
admet-286	206	2	net	net	ADJ
admet-286	206	3	bacterial	bacterial	ADJ
admet-286	206	4	growth	growth	NOUN
admet-286	206	5	(	(	PUNCT
admet-286	206	6	knet	knet	NOUN
admet-286	206	7	)	)	PUNCT
admet-286	206	8	was	be	AUX
admet-286	206	9	determined	determine	VERB
admet-286	206	10	from	from	ADP
admet-286	206	11	growth	growth	NOUN
admet-286	206	12	kinetics	kinetic	NOUN
admet-286	206	13	of	of	ADP
admet-286	206	14	bacteria	bacteria	NOUN
admet-286	206	15	without	without	ADP
admet-286	206	16	adding	add	VERB
admet-286	206	17	drug	drug	NOUN
admet-286	206	18	.	.	PUNCT
admet-286	207	1	for	for	ADP
admet-286	207	2	the	the	DET
admet-286	207	3	determination	determination	NOUN
admet-286	207	4	of	of	ADP
admet-286	207	5	emax	emax	NOUN
admet-286	207	6	,	,	PUNCT
admet-286	207	7	ec50	ec50	PROPN
admet-286	207	8	and	and	CCONJ
admet-286	207	9	γ	γ	PROPN
admet-286	207	10	,	,	PUNCT
admet-286	207	11	dose	dose	VERB
admet-286	207	12	response	response	NOUN
admet-286	207	13	curve	curve	NOUN
admet-286	207	14	was	be	AUX
admet-286	207	15	constructed	construct	VERB
admet-286	207	16	and	and	CCONJ
admet-286	207	17	analyzed	analyze	VERB
admet-286	207	18	using	use	VERB
admet-286	207	19	in	in	ADP
admet-286	207	20	vitro	vitro	X
admet-286	207	21	dilution	dilution	NOUN
admet-286	207	22	system	system	NOUN
admet-286	207	23	.	.	PUNCT
admet-286	208	1	depending	depend	VERB
admet-286	208	2	upon	upon	SCONJ
admet-286	208	3	the	the	DET
admet-286	208	4	therapeutic	therapeutic	ADJ
admet-286	208	5	action	action	NOUN
admet-286	208	6	needed	need	VERB
admet-286	208	7	,	,	PUNCT
admet-286	208	8	the	the	DET
admet-286	208	9	dose	dose	NOUN
admet-286	208	10	can	can	AUX
admet-286	208	11	be	be	AUX
admet-286	208	12	adjusted	adjust	VERB
admet-286	208	13	for	for	ADP
admet-286	208	14	enhanced	enhanced	ADJ
admet-286	208	15	pd	pd	PROPN
admet-286	208	16	effects	effect	NOUN
admet-286	208	17	using	use	VERB
admet-286	208	18	dose	dose	NOUN
admet-286	208	19	-	-	PUNCT
admet-286	208	20	response	response	NOUN
admet-286	208	21	relationship	relationship	NOUN
admet-286	208	22	(	(	PUNCT
admet-286	208	23	these	these	DET
admet-286	208	24	relationships	relationship	NOUN
admet-286	208	25	are	be	AUX
admet-286	208	26	reflections	reflection	NOUN
admet-286	208	27	of	of	ADP
admet-286	208	28	the	the	DET
admet-286	208	29	pharmacological	pharmacological	ADJ
admet-286	208	30	actions	action	NOUN
admet-286	208	31	of	of	ADP
admet-286	208	32	the	the	DET
admet-286	208	33	drug	drug	NOUN
admet-286	208	34	)	)	PUNCT
admet-286	208	35	.	.	PUNCT
admet-286	209	1	the	the	DET
admet-286	209	2	mrsa	mrsa	NOUN
admet-286	209	3	infections	infection	NOUN
admet-286	209	4	were	be	AUX
admet-286	209	5	exposed	expose	VERB
admet-286	209	6	to	to	ADP
admet-286	209	7	25	25	NUM
admet-286	209	8	,	,	PUNCT
admet-286	209	9	38	38	NUM
admet-286	209	10	,	,	PUNCT
admet-286	209	11	50	50	NUM
admet-286	209	12	,	,	PUNCT
admet-286	209	13	75	75	NUM
admet-286	209	14	and	and	CCONJ
admet-286	209	15	100	100	NUM
admet-286	209	16	%	%	NOUN
admet-286	209	17	of	of	ADP
admet-286	209	18	dosage	dosage	NOUN
admet-286	209	19	regimen	regiman	NOUN
admet-286	209	20	in	in	ADP
admet-286	209	21	in	in	ADP
admet-286	209	22	vitro	vitro	X
admet-286	209	23	chemostat	chemostat	NOUN
admet-286	209	24	system	system	NOUN
admet-286	209	25	and	and	CCONJ
admet-286	209	26	the	the	DET
admet-286	209	27	corresponding	corresponding	ADJ
admet-286	209	28	logarithmic	logarithmic	ADJ
admet-286	209	29	change	change	NOUN
admet-286	209	30	in	in	ADP
admet-286	209	31	bacterial	bacterial	ADJ
admet-286	209	32	densities	density	NOUN
admet-286	209	33	of	of	ADP
admet-286	209	34	0.08	0.08	NUM
admet-286	209	35	,	,	PUNCT
admet-286	209	36	4	4	NUM
admet-286	209	37	,	,	PUNCT
admet-286	209	38	4.6	4.6	NUM
admet-286	209	39	,	,	PUNCT
admet-286	209	40	4.48	4.48	NUM
admet-286	209	41	,	,	PUNCT
admet-286	209	42	and	and	CCONJ
admet-286	209	43	5.55	5.55	NUM
admet-286	209	44	were	be	AUX
admet-286	209	45	observed	observe	VERB
admet-286	209	46	respectively	respectively	ADV
admet-286	209	47	.	.	PUNCT
admet-286	210	1	the	the	DET
admet-286	210	2	dose	dose	NOUN
admet-286	210	3	response	response	NOUN
admet-286	210	4	curve	curve	NOUN
admet-286	210	5	was	be	AUX
admet-286	210	6	plotted	plot	VERB
admet-286	210	7	(	(	PUNCT
admet-286	210	8	figure	figure	NOUN
admet-286	210	9	s2	s2	PROPN
admet-286	210	10	)	)	PUNCT
admet-286	210	11	and	and	CCONJ
admet-286	210	12	the	the	DET
admet-286	210	13	data	datum	NOUN
admet-286	210	14	was	be	AUX
admet-286	210	15	fitted	fit	VERB
admet-286	210	16	with	with	ADP
admet-286	210	17	sigmoidal	sigmoidal	NOUN
admet-286	210	18	function	function	NOUN
admet-286	210	19	and	and	CCONJ
admet-286	210	20	ec50	ec50	PROPN
admet-286	210	21	of	of	ADP
admet-286	210	22	37.46	37.46	NUM
admet-286	210	23	%	%	NOUN
admet-286	210	24	was	be	AUX
admet-286	210	25	calculated	calculate	VERB
admet-286	210	26	(	(	PUNCT
admet-286	210	27	defined	define	VERB
admet-286	210	28	as	as	ADP
admet-286	210	29	a	a	DET
admet-286	210	30	percentage	percentage	NOUN
admet-286	210	31	of	of	ADP
admet-286	210	32	dose	dose	NOUN
admet-286	210	33	required	require	VERB
admet-286	210	34	to	to	PART
admet-286	210	35	attain	attain	VERB
admet-286	210	36	the	the	DET
admet-286	210	37	50	50	NUM
admet-286	210	38	percent	percent	NOUN
admet-286	210	39	of	of	ADP
admet-286	210	40	pd	pd	PROPN
admet-286	210	41	effect	effect	NOUN
admet-286	210	42	)	)	PUNCT
admet-286	210	43	.	.	PUNCT
admet-286	211	1	this	this	DET
admet-286	211	2	ec50	ec50	PROPN
admet-286	211	3	value	value	NOUN
admet-286	211	4	was	be	AUX
admet-286	211	5	used	use	VERB
admet-286	211	6	along	along	ADP
admet-286	211	7	with	with	ADP
admet-286	211	8	other	other	ADJ
admet-286	211	9	parameters	parameter	NOUN
admet-286	211	10	i.e.	i.e.	X
admet-286	211	11	emax	emax	X
admet-286	211	12	,	,	PUNCT
admet-286	211	13	γ	γ	X
admet-286	211	14	to	to	PART
admet-286	211	15	create	create	VERB
admet-286	211	16	the	the	DET
admet-286	211	17	semi	semi	ADJ
admet-286	211	18	-	-	ADJ
admet-286	211	19	mechanistic	mechanistic	ADJ
admet-286	211	20	antibacterial	antibacterial	ADJ
admet-286	211	21	bacterial	bacterial	ADJ
admet-286	211	22	-	-	PUNCT
admet-286	211	23	pk	pk	NOUN
admet-286	211	24	/	/	SYM
admet-286	211	25	pd	pd	PROPN
admet-286	211	26	model	model	NOUN
admet-286	211	27	.	.	PUNCT
admet-286	212	1	the	the	DET
admet-286	212	2	model	model	NOUN
admet-286	212	3	might	might	AUX
admet-286	212	4	help	help	VERB
admet-286	212	5	in	in	ADP
admet-286	212	6	determining	determine	VERB
admet-286	212	7	the	the	DET
admet-286	212	8	antibacterial	antibacterial	ADJ
admet-286	212	9	response	response	NOUN
admet-286	212	10	at	at	ADP
admet-286	212	11	a	a	DET
admet-286	212	12	given	give	VERB
admet-286	212	13	concentration	concentration	NOUN
admet-286	212	14	(	(	PUNCT
admet-286	212	15	and	and	CCONJ
admet-286	212	16	in	in	ADP
admet-286	212	17	clinical	clinical	ADJ
admet-286	212	18	settings	setting	NOUN
admet-286	212	19	at	at	ADP
admet-286	212	20	given	give	VERB
admet-286	212	21	dose	dose	NOUN
admet-286	212	22	)	)	PUNCT
admet-286	212	23	and	and	CCONJ
admet-286	212	24	could	could	AUX
admet-286	212	25	be	be	AUX
admet-286	212	26	extrapolated	extrapolate	VERB
admet-286	212	27	to	to	PART
admet-286	212	28	estimate	estimate	VERB
admet-286	212	29	dose	dose	NOUN
admet-286	212	30	requirements	requirement	NOUN
admet-286	212	31	for	for	ADP
admet-286	212	32	an	an	DET
admet-286	212	33	identified	identify	VERB
admet-286	212	34	patient	patient	NOUN
admet-286	212	35	’s	’s	PART
admet-286	212	36	bacterial	bacterial	ADJ
admet-286	212	37	load	load	NOUN
admet-286	212	38	in	in	ADP
admet-286	212	39	clinical	clinical	ADJ
admet-286	212	40	settings	setting	NOUN
admet-286	212	41	.	.	PUNCT
admet-286	213	1	pk	pk	PROPN
admet-286	213	2	/	/	SYM
admet-286	213	3	pd	pd	PROPN
admet-286	213	4	model	model	NOUN
admet-286	213	5	validation	validation	NOUN
admet-286	213	6	:	:	PUNCT
admet-286	213	7	the	the	DET
admet-286	213	8	final	final	ADJ
admet-286	213	9	pk	pk	NOUN
admet-286	213	10	/	/	SYM
admet-286	213	11	pd	pd	NOUN
admet-286	213	12	equation	equation	NOUN
admet-286	213	13	was	be	AUX
admet-286	213	14	validated	validate	VERB
admet-286	213	15	to	to	PART
admet-286	213	16	check	check	VERB
admet-286	213	17	its	its	PRON
admet-286	213	18	suitability	suitability	NOUN
admet-286	213	19	in	in	ADP
admet-286	213	20	dose	dose	NOUN
admet-286	213	21	recommendation	recommendation	NOUN
admet-286	213	22	using	use	VERB
admet-286	213	23	scientist	scientist	NOUN
admet-286	213	24	.	.	PUNCT
admet-286	214	1	the	the	DET
admet-286	214	2	experimental	experimental	ADJ
admet-286	214	3	data	datum	NOUN
admet-286	214	4	for	for	ADP
admet-286	214	5	dose	dose	NOUN
admet-286	214	6	escalation	escalation	NOUN
admet-286	214	7	studies	study	NOUN
admet-286	214	8	were	be	AUX
admet-286	214	9	fitted	fit	VERB
admet-286	214	10	using	use	VERB
admet-286	214	11	equation-3	equation-3	PROPN
admet-286	214	12	.	.	PUNCT
admet-286	215	1	the	the	DET
admet-286	215	2	goodness	goodness	NOUN
admet-286	215	3	of	of	ADP
admet-286	215	4	fit	fit	ADJ
admet-286	215	5	and	and	CCONJ
admet-286	215	6	95	95	NUM
admet-286	215	7	%	%	NOUN
admet-286	215	8	confidence	confidence	NOUN
admet-286	215	9	interval	interval	NOUN
admet-286	215	10	of	of	ADP
admet-286	215	11	simulated	simulate	VERB
admet-286	215	12	data	datum	NOUN
admet-286	215	13	were	be	AUX
admet-286	215	14	evaluated	evaluate	VERB
admet-286	215	15	for	for	ADP
admet-286	215	16	first	first	ADJ
admet-286	215	17	8	8	NUM
admet-286	215	18	h	h	NOUN
admet-286	215	19	(	(	PUNCT
admet-286	215	20	before	before	ADP
admet-286	215	21	the	the	DET
admet-286	215	22	addition	addition	NOUN
admet-286	215	23	of	of	ADP
admet-286	215	24	second	second	ADJ
admet-286	215	25	inoculum	inoculum	NOUN
admet-286	215	26	)	)	PUNCT
admet-286	215	27	.	.	PUNCT
admet-286	216	1	simulations	simulation	NOUN
admet-286	216	2	after	after	SCONJ
admet-286	216	3	8	8	NUM
admet-286	216	4	h	h	NOUN
admet-286	216	5	of	of	ADP
admet-286	216	6	drug	drug	NOUN
admet-286	216	7	exposure	exposure	NOUN
admet-286	216	8	were	be	AUX
admet-286	216	9	not	not	PART
admet-286	216	10	shown	show	VERB
admet-286	216	11	in	in	ADP
admet-286	216	12	case	case	NOUN
admet-286	216	13	of	of	ADP
admet-286	216	14	dose	dose	NOUN
admet-286	216	15	-	-	PUNCT
admet-286	216	16	escalation	escalation	NOUN
admet-286	216	17	study	study	NOUN
admet-286	216	18	in	in	ADP
admet-286	216	19	order	order	NOUN
admet-286	216	20	to	to	PART
admet-286	216	21	focus	focus	VERB
admet-286	216	22	mainly	mainly	ADV
admet-286	216	23	on	on	ADP
admet-286	216	24	initial	initial	ADJ
admet-286	216	25	exposure	exposure	NOUN
admet-286	216	26	of	of	ADP
admet-286	216	27	drug	drug	NOUN
admet-286	216	28	,	,	PUNCT
admet-286	216	29	where	where	SCONJ
admet-286	216	30	most	most	ADJ
admet-286	216	31	of	of	ADP
admet-286	216	32	the	the	DET
admet-286	216	33	bacterial	bacterial	ADJ
admet-286	216	34	killing	killing	NOUN
admet-286	216	35	occurred	occur	VERB
admet-286	216	36	.	.	PUNCT
admet-286	217	1	the	the	DET
admet-286	217	2	semi	semi	ADJ
admet-286	217	3	-	-	ADJ
admet-286	217	4	mechanistic	mechanistic	ADJ
admet-286	217	5	-	-	PUNCT
admet-286	217	6	pk	pk	NOUN
admet-286	217	7	/	/	SYM
admet-286	217	8	pd	pd	NOUN
admet-286	217	9	model	model	NOUN
admet-286	217	10	predictions	prediction	NOUN
admet-286	217	11	were	be	AUX
admet-286	217	12	improved	improve	VERB
admet-286	217	13	with	with	ADP
admet-286	217	14	an	an	DET
admet-286	217	15	increase	increase	NOUN
admet-286	217	16	in	in	ADP
admet-286	217	17	dose	dose	NOUN
admet-286	217	18	exposure	exposure	NOUN
admet-286	217	19	.	.	PUNCT
admet-286	218	1	for	for	ADP
admet-286	218	2	instance	instance	NOUN
admet-286	218	3	,	,	PUNCT
admet-286	218	4	r2	r2	PROPN
admet-286	218	5	values	value	NOUN
admet-286	218	6	for	for	ADP
admet-286	218	7	the	the	DET
admet-286	218	8	fitted	fit	VERB
admet-286	218	9	values	value	NOUN
admet-286	218	10	of	of	ADP
admet-286	218	11	dose	dose	ADJ
admet-286	218	12	exposures	exposure	NOUN
admet-286	218	13	of	of	ADP
admet-286	218	14	20x	20x	NOUN
admet-286	218	15	,	,	PUNCT
admet-286	218	16	50x	50x	NUM
admet-286	218	17	,	,	PUNCT
admet-286	218	18	100x	100x	NUM
admet-286	218	19	and	and	CCONJ
admet-286	218	20	200x	200x	NUM
admet-286	218	21	mic	mic	NOUN
admet-286	218	22	were	be	AUX
admet-286	218	23	0.633	0.633	NUM
admet-286	218	24	,	,	PUNCT
admet-286	218	25	0.856	0.856	NUM
admet-286	218	26	,	,	PUNCT
admet-286	218	27	0.964	0.964	NUM
admet-286	218	28	and	and	CCONJ
admet-286	218	29	0.965	0.965	NUM
admet-286	218	30	respectively	respectively	ADV
admet-286	218	31	(	(	PUNCT
admet-286	218	32	figure	figure	NOUN
admet-286	218	33	6a	6a	NOUN
admet-286	218	34	,	,	PUNCT
admet-286	218	35	6b	6b	NOUN
admet-286	218	36	,	,	PUNCT
admet-286	218	37	6c	6c	NOUN
admet-286	218	38	and	and	CCONJ
admet-286	218	39	6d	6d	NUM
admet-286	218	40	)	)	PUNCT
admet-286	218	41	suggesting	suggest	VERB
admet-286	218	42	better	well	ADJ
admet-286	218	43	predictability	predictability	NOUN
admet-286	218	44	of	of	ADP
admet-286	218	45	model	model	NOUN
admet-286	218	46	at	at	ADP
admet-286	218	47	comparitively	comparitively	ADV
admet-286	218	48	higher	high	ADJ
admet-286	218	49	exposures	exposure	NOUN
admet-286	218	50	.	.	PUNCT
admet-286	219	1	additionally	additionally	ADV
admet-286	219	2	,	,	PUNCT
admet-286	219	3	most	most	ADJ
admet-286	219	4	of	of	ADP
admet-286	219	5	the	the	DET
admet-286	219	6	experimental	experimental	ADJ
admet-286	219	7	data	data	NOUN
admet-286	219	8	points	point	NOUN
admet-286	219	9	were	be	AUX
admet-286	219	10	under	under	ADP
admet-286	219	11	95	95	NUM
admet-286	219	12	%	%	NOUN
admet-286	219	13	confidence	confidence	NOUN
admet-286	219	14	interval	interval	NOUN
admet-286	219	15	of	of	ADP
admet-286	219	16	simulated	simulated	ADJ
admet-286	219	17	data	datum	NOUN
admet-286	219	18	,	,	PUNCT
admet-286	219	19	which	which	PRON
admet-286	219	20	further	far	ADV
admet-286	219	21	supports	support	VERB
admet-286	219	22	the	the	DET
admet-286	219	23	validity	validity	NOUN
admet-286	219	24	of	of	ADP
admet-286	219	25	pk	pk	PROPN
admet-286	219	26	/	/	SYM
admet-286	219	27	pd	pd	PROPN
admet-286	219	28	model	model	NOUN
admet-286	219	29	.	.	PUNCT
admet-286	220	1	vishnu	vishnu	PROPN
admet-286	220	2	sharma	sharma	PROPN
admet-286	220	3	et	et	PROPN
admet-286	220	4	al	al	PROPN
admet-286	220	5	.	.	PROPN
admet-286	220	6	admet	admet	PROPN
admet-286	220	7	&	&	CCONJ
admet-286	220	8	dmpk	dmpk	PROPN
admet-286	220	9	4(3	4(3	NUM
admet-286	220	10	)	)	PUNCT
admet-286	220	11	(	(	PUNCT
admet-286	220	12	2016	2016	NUM
admet-286	220	13	)	)	PUNCT
admet-286	220	14	241	241	NUM
admet-286	220	15	-	-	SYM
admet-286	220	16	260	260	NUM
admet-286	220	17	252	252	NUM
admet-286	220	18	figure	figure	NOUN
admet-286	220	19	6	6	NUM
admet-286	220	20	.	.	PUNCT
admet-286	221	1	the	the	DET
admet-286	221	2	experimental	experimental	ADJ
admet-286	221	3	data	datum	NOUN
admet-286	221	4	was	be	AUX
admet-286	221	5	fitted	fit	VERB
admet-286	221	6	with	with	ADP
admet-286	221	7	the	the	DET
admet-286	221	8	antibacterial	antibacterial	ADJ
admet-286	221	9	-	-	PUNCT
admet-286	221	10	pk	pk	NOUN
admet-286	221	11	/	/	SYM
admet-286	221	12	pd	pd	NOUN
admet-286	221	13	model	model	NOUN
admet-286	221	14	using	use	VERB
admet-286	221	15	non	non	ADJ
admet-286	221	16	-	-	ADJ
admet-286	221	17	linear	linear	ADJ
admet-286	221	18	least	least	ADJ
admet-286	221	19	-	-	PUNCT
admet-286	221	20	square	square	NOUN
admet-286	221	21	regression	regression	NOUN
admet-286	221	22	program	program	NOUN
admet-286	221	23	scientist	scientist	NOUN
admet-286	221	24	.	.	PUNCT
admet-286	222	1	(	(	PUNCT
admet-286	222	2	i	i	NOUN
admet-286	222	3	)	)	PUNCT
admet-286	222	4	validation	validation	NOUN
admet-286	222	5	based	base	VERB
admet-286	222	6	on	on	ADP
admet-286	222	7	dose	dose	NOUN
admet-286	222	8	escalation	escalation	NOUN
admet-286	222	9	studies	study	NOUN
admet-286	222	10	data	datum	NOUN
admet-286	222	11	(	(	PUNCT
admet-286	222	12	a	a	DET
admet-286	222	13	,	,	PUNCT
admet-286	222	14	b	b	NOUN
admet-286	222	15	,	,	PUNCT
admet-286	222	16	c	c	X
admet-286	222	17	,	,	PUNCT
admet-286	222	18	d):the	d):the	DET
admet-286	222	19	data	datum	NOUN
admet-286	222	20	of	of	ADP
admet-286	222	21	dose	dose	NOUN
admet-286	222	22	escalation	escalation	NOUN
admet-286	222	23	from	from	ADP
admet-286	222	24	20	20	NUM
admet-286	222	25	folds	fold	NOUN
admet-286	222	26	to	to	ADP
admet-286	222	27	200	200	NUM
admet-286	222	28	folds	fold	NOUN
admet-286	222	29	of	of	ADP
admet-286	222	30	mic	mic	NOUN
admet-286	222	31	was	be	AUX
admet-286	222	32	validated	validate	VERB
admet-286	222	33	with	with	ADP
admet-286	222	34	the	the	DET
admet-286	222	35	model	model	NOUN
admet-286	222	36	;	;	PUNCT
admet-286	222	37	(	(	PUNCT
admet-286	222	38	ii	ii	NOUN
admet-286	222	39	)	)	PUNCT
admet-286	222	40	validation	validation	NOUN
admet-286	222	41	based	base	VERB
admet-286	222	42	on	on	ADP
admet-286	222	43	dose	dose	NOUN
admet-286	222	44	fractionation	fractionation	NOUN
admet-286	222	45	studies	study	NOUN
admet-286	222	46	data	datum	NOUN
admet-286	222	47	:	:	PUNCT
admet-286	222	48	the	the	DET
admet-286	222	49	data	datum	NOUN
admet-286	222	50	of	of	ADP
admet-286	222	51	dose	dose	NOUN
admet-286	222	52	fractionation	fractionation	NOUN
admet-286	222	53	i.e.	i.e.	X
admet-286	222	54	once	once	ADV
admet-286	222	55	-	-	PUNCT
admet-286	222	56	a	a	DET
admet-286	222	57	-	-	PUNCT
admet-286	222	58	day	day	NOUN
admet-286	222	59	(	(	PUNCT
admet-286	222	60	e	e	NOUN
admet-286	222	61	)	)	PUNCT
admet-286	222	62	,	,	PUNCT
admet-286	222	63	twice	twice	ADV
admet-286	222	64	-	-	PUNCT
admet-286	222	65	a	a	DET
admet-286	222	66	-	-	PUNCT
admet-286	222	67	day(f	day(f	PROPN
admet-286	222	68	)	)	PUNCT
admet-286	222	69	and	and	CCONJ
admet-286	222	70	thrice	thrice	NOUN
admet-286	222	71	-	-	PUNCT
admet-286	222	72	a	a	DET
admet-286	222	73	-	-	PUNCT
admet-286	222	74	day	day	NOUN
admet-286	222	75	(	(	PUNCT
admet-286	222	76	g	g	NOUN
admet-286	222	77	)	)	PUNCT
admet-286	222	78	was	be	AUX
admet-286	222	79	validated	validate	VERB
admet-286	222	80	with	with	ADP
admet-286	222	81	the	the	DET
admet-286	222	82	model	model	NOUN
admet-286	222	83	.	.	PUNCT
admet-286	223	1	the	the	DET
admet-286	223	2	model	model	NOUN
admet-286	223	3	(	(	PUNCT
admet-286	223	4	equation	equation	NOUN
admet-286	223	5	3	3	NUM
admet-286	223	6	)	)	PUNCT
admet-286	223	7	was	be	AUX
admet-286	223	8	further	far	ADV
admet-286	223	9	applied	apply	VERB
admet-286	223	10	to	to	ADP
admet-286	223	11	experimental	experimental	ADJ
admet-286	223	12	data	datum	NOUN
admet-286	223	13	of	of	ADP
admet-286	223	14	dose	dose	NOUN
admet-286	223	15	fractionation	fractionation	NOUN
admet-286	223	16	.	.	PUNCT
admet-286	224	1	since	since	SCONJ
admet-286	224	2	,	,	PUNCT
admet-286	224	3	dose	dose	NOUN
admet-286	224	4	frequency	frequency	NOUN
admet-286	224	5	is	be	AUX
admet-286	224	6	a	a	DET
admet-286	224	7	main	main	ADJ
admet-286	224	8	factor	factor	NOUN
admet-286	224	9	in	in	ADP
admet-286	224	10	dose	dose	NOUN
admet-286	224	11	fractionation	fractionation	NOUN
admet-286	224	12	data	datum	NOUN
admet-286	224	13	,	,	PUNCT
admet-286	224	14	model	model	NOUN
admet-286	224	15	predictions	prediction	NOUN
admet-286	224	16	were	be	AUX
admet-286	224	17	extended	extend	VERB
admet-286	224	18	to	to	ADP
admet-286	224	19	24	24	NUM
admet-286	224	20	hours	hour	NOUN
admet-286	224	21	.	.	PUNCT
admet-286	225	1	the	the	DET
admet-286	225	2	observed	observe	VERB
admet-286	225	3	values	value	NOUN
admet-286	225	4	of	of	ADP
admet-286	225	5	experiments	experiment	NOUN
admet-286	225	6	and	and	CCONJ
admet-286	225	7	predicted	predict	VERB
admet-286	225	8	values	value	NOUN
admet-286	225	9	of	of	ADP
admet-286	225	10	model	model	NOUN
admet-286	225	11	were	be	AUX
admet-286	225	12	plotted	plot	VERB
admet-286	225	13	for	for	ADP
admet-286	225	14	all	all	DET
admet-286	225	15	three	three	NUM
admet-286	225	16	dosage	dosage	NOUN
admet-286	225	17	regimens	regimen	NOUN
admet-286	225	18	i.e.	i.e.	X
admet-286	225	19	once	once	ADV
admet-286	225	20	-	-	PUNCT
admet-286	225	21	a	a	DET
admet-286	225	22	-	-	PUNCT
admet-286	225	23	day	day	NOUN
admet-286	225	24	,	,	PUNCT
admet-286	225	25	twice	twice	DET
admet-286	225	26	-	-	PUNCT
admet-286	225	27	a	a	DET
admet-286	225	28	-	-	PUNCT
admet-286	225	29	day	day	NOUN
admet-286	225	30	and	and	CCONJ
admet-286	225	31	thrice	thrice	NOUN
admet-286	225	32	-	-	PUNCT
admet-286	225	33	a	a	DET
admet-286	225	34	-	-	PUNCT
admet-286	225	35	day	day	NOUN
admet-286	225	36	(	(	PUNCT
admet-286	225	37	figure	figure	NOUN
admet-286	225	38	6e	6e	NOUN
admet-286	225	39	,	,	PUNCT
admet-286	225	40	6f	6f	NUM
admet-286	225	41	and	and	CCONJ
admet-286	225	42	6	6	NUM
admet-286	225	43	g	g	NOUN
admet-286	225	44	)	)	PUNCT
admet-286	225	45	.	.	PUNCT
admet-286	226	1	the	the	DET
admet-286	226	2	addition	addition	NOUN
admet-286	226	3	of	of	ADP
admet-286	226	4	second	second	ADJ
admet-286	226	5	inocula	inocula	NOUN
admet-286	226	6	at	at	ADP
admet-286	226	7	9.5	9.5	NUM
admet-286	226	8	h	h	NOUN
admet-286	226	9	had	have	AUX
admet-286	226	10	raised	raise	VERB
admet-286	226	11	the	the	DET
admet-286	226	12	cfu	cfu	NOUN
admet-286	226	13	counts	count	NOUN
admet-286	226	14	,	,	PUNCT
admet-286	226	15	as	as	SCONJ
admet-286	226	16	shown	show	VERB
admet-286	226	17	by	by	ADP
admet-286	226	18	corresponding	correspond	VERB
admet-286	226	19	downward	downward	ADJ
admet-286	226	20	peak	peak	NOUN
admet-286	226	21	in	in	ADP
admet-286	226	22	all	all	DET
admet-286	226	23	three	three	NUM
admet-286	226	24	cases	case	NOUN
admet-286	226	25	.	.	PUNCT
admet-286	227	1	also	also	ADV
admet-286	227	2	as	as	SCONJ
admet-286	227	3	mentioned	mention	VERB
admet-286	227	4	before	before	ADV
admet-286	227	5	,	,	PUNCT
admet-286	227	6	model	model	NOUN
admet-286	227	7	was	be	AUX
admet-286	227	8	weak	weak	ADJ
admet-286	227	9	for	for	ADP
admet-286	227	10	lower	low	ADJ
admet-286	227	11	concentrations	concentration	NOUN
admet-286	227	12	of	of	ADP
admet-286	227	13	drug	drug	NOUN
admet-286	227	14	,	,	PUNCT
admet-286	227	15	as	as	SCONJ
admet-286	227	16	observed	observe	VERB
admet-286	227	17	in	in	ADP
admet-286	227	18	20	20	NUM
admet-286	227	19	-	-	SYM
admet-286	227	20	24	24	NUM
admet-286	227	21	h	h	NOUN
admet-286	227	22	of	of	ADP
admet-286	227	23	once	once	ADV
admet-286	227	24	-	-	PUNCT
admet-286	227	25	a	a	DET
admet-286	227	26	-	-	PUNCT
admet-286	227	27	day	day	NOUN
admet-286	227	28	dosing	dose	VERB
admet-286	227	29	(	(	PUNCT
admet-286	227	30	figure	figure	NOUN
admet-286	227	31	6e	6e	NOUN
admet-286	227	32	)	)	PUNCT
admet-286	227	33	and	and	CCONJ
admet-286	227	34	16	16	NUM
admet-286	227	35	-	-	SYM
admet-286	227	36	24	24	NUM
admet-286	227	37	h	h	NOUN
admet-286	227	38	of	of	ADP
admet-286	227	39	thrice	thrice	NOUN
admet-286	227	40	-	-	PUNCT
admet-286	227	41	a	a	DET
admet-286	227	42	-	-	PUNCT
admet-286	227	43	day	day	NOUN
admet-286	227	44	dosing	dose	VERB
admet-286	227	45	(	(	PUNCT
admet-286	227	46	figure	figure	NOUN
admet-286	227	47	6	6	NUM
admet-286	227	48	g	g	NOUN
admet-286	227	49	)	)	PUNCT
admet-286	227	50	of	of	ADP
admet-286	227	51	ceftriaxone	ceftriaxone	PROPN
admet-286	227	52	/	/	SYM
admet-286	227	53	vancomycin	vancomycin	PROPN
admet-286	227	54	(	(	PUNCT
admet-286	227	55	2/1	2/1	NUM
admet-286	227	56	)	)	PUNCT
admet-286	227	57	.	.	PUNCT
admet-286	228	1	therefore	therefore	ADV
admet-286	228	2	,	,	PUNCT
admet-286	228	3	weak	weak	ADJ
admet-286	228	4	correlation	correlation	NOUN
admet-286	228	5	was	be	AUX
admet-286	228	6	observed	observe	VERB
admet-286	228	7	in	in	ADP
admet-286	228	8	all	all	DET
admet-286	228	9	three	three	NUM
admet-286	228	10	cases	case	NOUN
admet-286	228	11	as	as	SCONJ
admet-286	228	12	compared	compare	VERB
admet-286	228	13	to	to	PART
admet-286	228	14	dose	dose	VERB
admet-286	228	15	escalation	escalation	NOUN
admet-286	228	16	studies	study	NOUN
admet-286	228	17	.	.	PUNCT
admet-286	229	1	the	the	DET
admet-286	229	2	correlation	correlation	NOUN
admet-286	229	3	coefficents	coefficent	VERB
admet-286	229	4	increases	increase	NOUN
admet-286	229	5	from	from	ADP
admet-286	229	6	0.6682	0.6682	NUM
admet-286	229	7	of	of	ADP
admet-286	229	8	once	once	ADV
admet-286	229	9	-	-	PUNCT
admet-286	229	10	a	a	DET
admet-286	229	11	-	-	PUNCT
admet-286	229	12	day	day	NOUN
admet-286	229	13	dosing	dose	VERB
admet-286	229	14	to	to	ADP
admet-286	229	15	0.6927	0.6927	NUM
admet-286	229	16	of	of	ADP
admet-286	229	17	twice	twice	ADV
admet-286	229	18	-	-	PUNCT
admet-286	229	19	a	a	DET
admet-286	229	20	-	-	PUNCT
admet-286	229	21	dosing	dosing	NOUN
admet-286	229	22	of	of	ADP
admet-286	229	23	the	the	DET
admet-286	229	24	fdc	fdc	PROPN
admet-286	229	25	of	of	ADP
admet-286	229	26	antibiotics	antibiotic	NOUN
admet-286	229	27	.	.	PUNCT
admet-286	230	1	further	further	ADJ
admet-286	230	2	increase	increase	VERB
admet-286	230	3	in	in	ADP
admet-286	230	4	dose	dose	NOUN
admet-286	230	5	fractionation	fractionation	NOUN
admet-286	230	6	reduces	reduce	VERB
admet-286	230	7	drastically	drastically	ADV
admet-286	230	8	the	the	DET
admet-286	230	9	correlation	correlation	NOUN
admet-286	230	10	coefficient	coefficient	NOUN
admet-286	230	11	to	to	ADP
admet-286	230	12	0.3643	0.3643	NUM
admet-286	230	13	,	,	PUNCT
admet-286	230	14	which	which	PRON
admet-286	230	15	suggests	suggest	VERB
admet-286	230	16	the	the	DET
admet-286	230	17	model	model	NOUN
admet-286	230	18	weakness	weakness	NOUN
admet-286	230	19	in	in	ADP
admet-286	230	20	predicton	predicton	NOUN
admet-286	230	21	of	of	ADP
admet-286	230	22	lower	low	ADJ
admet-286	230	23	drug	drug	NOUN
admet-286	230	24	concentrations	concentration	NOUN
admet-286	230	25	.	.	PUNCT
admet-286	231	1	however	however	ADV
admet-286	231	2	,	,	PUNCT
admet-286	231	3	the	the	DET
admet-286	231	4	model	model	NOUN
admet-286	231	5	was	be	AUX
admet-286	231	6	appropiate	appropiate	ADJ
admet-286	231	7	for	for	ADP
admet-286	231	8	the	the	DET
admet-286	231	9	twice	twice	ADV
admet-286	231	10	-	-	PUNCT
admet-286	231	11	a	a	DET
admet-286	231	12	-	-	PUNCT
admet-286	231	13	day	day	NOUN
admet-286	231	14	dose	dose	NOUN
admet-286	231	15	frequency	frequency	NOUN
admet-286	231	16	,	,	PUNCT
admet-286	231	17	which	which	PRON
admet-286	231	18	was	be	AUX
admet-286	231	19	also	also	ADV
admet-286	231	20	the	the	DET
admet-286	231	21	best	good	ADJ
admet-286	231	22	dosage	dosage	NOUN
admet-286	231	23	regimen	regiman	NOUN
admet-286	231	24	for	for	ADP
admet-286	231	25	ceftriaxone	ceftriaxone	PROPN
admet-286	231	26	/	/	SYM
admet-286	231	27	vancomycin	vancomycin	PROPN
admet-286	231	28	(	(	PUNCT
admet-286	231	29	2/1	2/1	NUM
admet-286	231	30	)	)	PUNCT
admet-286	231	31	fdc	fdc	PROPN
admet-286	231	32	combination	combination	NOUN
admet-286	231	33	.	.	PUNCT
admet-286	232	1	the	the	DET
admet-286	232	2	same	same	ADJ
admet-286	232	3	conclusion	conclusion	NOUN
admet-286	232	4	was	be	AUX
admet-286	232	5	derived	derive	VERB
admet-286	232	6	from	from	ADP
admet-286	232	7	the	the	DET
admet-286	232	8	95	95	NUM
admet-286	232	9	%	%	NOUN
admet-286	232	10	confidence	confidence	NOUN
admet-286	232	11	interval	interval	NOUN
admet-286	232	12	of	of	ADP
admet-286	232	13	simulated	simulated	ADJ
admet-286	232	14	data	datum	NOUN
admet-286	232	15	.	.	PUNCT
admet-286	233	1	most	most	ADJ
admet-286	233	2	of	of	ADP
admet-286	233	3	the	the	DET
admet-286	233	4	data	datum	NOUN
admet-286	233	5	of	of	ADP
admet-286	233	6	twice	twice	ADV
admet-286	233	7	-	-	PUNCT
admet-286	233	8	a	a	DET
admet-286	233	9	-	-	PUNCT
admet-286	233	10	day	day	NOUN
admet-286	233	11	dosing	dose	VERB
admet-286	233	12	were	be	AUX
admet-286	233	13	in	in	ADP
admet-286	233	14	the	the	DET
admet-286	233	15	upper	upper	ADJ
admet-286	233	16	and	and	CCONJ
admet-286	233	17	lower	low	ADJ
admet-286	233	18	limits	limit	NOUN
admet-286	233	19	of	of	ADP
admet-286	233	20	confidence	confidence	NOUN
admet-286	233	21	interval	interval	NOUN
admet-286	233	22	,	,	PUNCT
admet-286	233	23	followed	follow	VERB
admet-286	233	24	by	by	ADP
admet-286	233	25	once	once	ADV
admet-286	233	26	-	-	PUNCT
admet-286	233	27	a	a	DET
admet-286	233	28	-	-	PUNCT
admet-286	233	29	day	day	NOUN
admet-286	233	30	dosing	dose	VERB
admet-286	233	31	(	(	PUNCT
admet-286	233	32	figure	figure	NOUN
admet-286	233	33	6	6	NUM
admet-286	233	34	)	)	PUNCT
admet-286	233	35	.	.	PUNCT
admet-286	234	1	again	again	ADV
admet-286	234	2	in	in	ADP
admet-286	234	3	case	case	NOUN
admet-286	234	4	of	of	ADP
admet-286	234	5	thrice	thrice	NOUN
admet-286	234	6	-	-	PUNCT
admet-286	234	7	a	a	DET
admet-286	234	8	-	-	PUNCT
admet-286	234	9	day	day	NOUN
admet-286	234	10	dose	dose	NOUN
admet-286	234	11	frequency	frequency	NOUN
admet-286	234	12	,	,	PUNCT
admet-286	234	13	predicted	predict	VERB
admet-286	234	14	values	value	NOUN
admet-286	234	15	were	be	AUX
admet-286	234	16	poorly	poorly	ADV
admet-286	234	17	correlated	correlate	VERB
admet-286	234	18	with	with	ADP
admet-286	234	19	the	the	DET
admet-286	234	20	experimental	experimental	ADJ
admet-286	234	21	values	value	NOUN
admet-286	234	22	(	(	PUNCT
admet-286	234	23	figure	figure	NOUN
admet-286	234	24	6	6	NUM
admet-286	234	25	g	g	NOUN
admet-286	234	26	)	)	PUNCT
admet-286	234	27	.	.	PUNCT
admet-286	235	1	dose	dose	NOUN
admet-286	235	2	optimization	optimization	NOUN
admet-286	235	3	using	use	VERB
admet-286	235	4	monte	monte	PROPN
admet-286	235	5	carlo	carlo	PROPN
admet-286	235	6	simulations	simulation	NOUN
admet-286	235	7	:	:	PUNCT
admet-286	235	8	the	the	DET
admet-286	235	9	pk	pk	PROPN
admet-286	235	10	-	-	PUNCT
admet-286	235	11	pd	pd	NOUN
admet-286	235	12	studies	study	NOUN
admet-286	235	13	were	be	AUX
admet-286	235	14	done	do	VERB
admet-286	235	15	using	use	VERB
admet-286	235	16	the	the	DET
admet-286	235	17	fixed	fix	VERB
admet-286	235	18	values	value	NOUN
admet-286	235	19	of	of	ADP
admet-286	235	20	primary	primary	ADJ
admet-286	235	21	pk	pk	NOUN
admet-286	235	22	parameters	parameter	NOUN
admet-286	235	23	and	and	CCONJ
admet-286	235	24	mic	mic	NOUN
admet-286	235	25	;	;	PUNCT
admet-286	235	26	which	which	PRON
admet-286	235	27	did	do	AUX
admet-286	235	28	not	not	PART
admet-286	235	29	account	account	VERB
admet-286	235	30	the	the	DET
admet-286	235	31	pk	pk	NOUN
admet-286	235	32	variability	variability	NOUN
admet-286	235	33	of	of	ADP
admet-286	235	34	a	a	DET
admet-286	235	35	clinical	clinical	ADJ
admet-286	235	36	population	population	NOUN
admet-286	235	37	.	.	PUNCT
admet-286	236	1	in	in	ADP
admet-286	236	2	order	order	NOUN
admet-286	236	3	to	to	PART
admet-286	236	4	account	account	VERB
admet-286	236	5	for	for	ADP
admet-286	236	6	the	the	DET
admet-286	236	7	randomness	randomness	NOUN
admet-286	236	8	/	/	SYM
admet-286	236	9	variability	variability	NOUN
admet-286	236	10	in	in	ADP
admet-286	236	11	human	human	ADJ
admet-286	236	12	pks	pks	NOUN
admet-286	236	13	and	and	CCONJ
admet-286	236	14	mics	mic	NOUN
admet-286	236	15	,	,	PUNCT
admet-286	236	16	monte	monte	PROPN
admet-286	236	17	carlo	carlo	PROPN
admet-286	236	18	simulations	simulation	NOUN
admet-286	236	19	of	of	ADP
admet-286	236	20	1000	1000	NUM
admet-286	236	21	subjects	subject	NOUN
admet-286	236	22	were	be	AUX
admet-286	236	23	done	do	VERB
admet-286	236	24	to	to	PART
admet-286	236	25	determine	determine	VERB
admet-286	236	26	how	how	SCONJ
admet-286	236	27	likely	likely	ADV
admet-286	236	28	the	the	DET
admet-286	236	29	given	give	VERB
admet-286	236	30	exposure	exposure	NOUN
admet-286	236	31	of	of	ADP
admet-286	236	32	fdc	fdc	PROPN
admet-286	236	33	would	would	AUX
admet-286	236	34	achieve	achieve	VERB
admet-286	236	35	the	the	DET
admet-286	236	36	target	target	NOUN
admet-286	236	37	%	%	NOUN
admet-286	236	38	t	t	PROPN
admet-286	236	39	>	>	X
admet-286	236	40	miccomb	miccomb	PROPN
admet-286	236	41	or	or	CCONJ
admet-286	236	42	auccomb	auccomb	NOUN
admet-286	236	43	(	(	PUNCT
admet-286	236	44	reported	report	VERB
admet-286	236	45	as	as	ADP
admet-286	236	46	pta	pta	NOUN
admet-286	236	47	)	)	PUNCT
admet-286	236	48	.	.	PUNCT
admet-286	237	1	the	the	DET
admet-286	237	2	pk	pk	NOUN
admet-286	237	3	parameters	parameter	NOUN
admet-286	237	4	utilized	utilize	VERB
admet-286	237	5	were	be	AUX
admet-286	237	6	clearance	clearance	NOUN
admet-286	237	7	of	of	ADP
admet-286	237	8	0.88	0.88	NUM
admet-286	237	9	+	+	NOUN
admet-286	237	10	/0.431	/0.431	PUNCT
admet-286	237	11	l	l	NOUN
admet-286	237	12	/	/	SYM
admet-286	237	13	h	h	NOUN
admet-286	237	14	and	and	CCONJ
admet-286	237	15	4.8	4.8	NUM
admet-286	237	16	+	+	ADV
admet-286	237	17	/-1.9	/-1.9	ADJ
admet-286	237	18	l	l	ADJ
admet-286	237	19	/	/	SYM
admet-286	237	20	h	h	NOUN
admet-286	237	21	and	and	CCONJ
admet-286	237	22	elimination	elimination	NOUN
admet-286	237	23	rate	rate	NOUN
admet-286	237	24	constant	constant	ADJ
admet-286	237	25	of	of	ADP
admet-286	237	26	0.113	0.113	NUM
admet-286	237	27	and	and	CCONJ
admet-286	237	28	0.11	0.11	NUM
admet-286	237	29	h-1	h-1	NOUN
admet-286	237	30	for	for	ADP
admet-286	237	31	ceftriaxone	ceftriaxone	NOUN
admet-286	237	32	and	and	CCONJ
admet-286	237	33	vancomycin	vancomycin	PROPN
admet-286	237	34	respectively	respectively	ADV
admet-286	237	35	,	,	PUNCT
admet-286	237	36	on	on	ADP
admet-286	237	37	the	the	DET
admet-286	237	38	basis	basis	NOUN
admet-286	237	39	of	of	ADP
admet-286	237	40	literature	literature	NOUN
admet-286	238	1	[	[	X
admet-286	238	2	30,31	30,31	PROPN
admet-286	238	3	]	]	PUNCT
admet-286	238	4	.	.	PUNCT
admet-286	239	1	monte	monte	PROPN
admet-286	239	2	carlo	carlo	PROPN
admet-286	239	3	simulations	simulation	NOUN
admet-286	239	4	were	be	AUX
admet-286	239	5	done	do	VERB
admet-286	239	6	for	for	ADP
admet-286	239	7	both	both	DET
admet-286	239	8	pk	pk	PROPN
admet-286	239	9	/	/	SYM
admet-286	239	10	pd	pd	PROPN
admet-286	239	11	indices	index	NOUN
admet-286	239	12	i.e.	i.e.	X
admet-286	239	13	auccomb	auccomb	NOUN
admet-286	239	14	and	and	CCONJ
admet-286	239	15	%	%	INTJ
admet-286	239	16	t	t	X
admet-286	239	17	>	>	X
admet-286	239	18	miccomb	miccomb	PROPN
admet-286	239	19	(	(	PUNCT
admet-286	239	20	figure	figure	NOUN
admet-286	239	21	7a	7a	NOUN
admet-286	239	22	and	and	CCONJ
admet-286	239	23	7b	7b	NUM
admet-286	239	24	)	)	PUNCT
admet-286	239	25	.	.	PUNCT
admet-286	240	1	the	the	DET
admet-286	240	2	selection	selection	NOUN
admet-286	240	3	of	of	ADP
admet-286	240	4	the	the	DET
admet-286	240	5	pta	pta	PROPN
admet-286	240	6	target	target	NOUN
admet-286	240	7	set	set	NOUN
admet-286	240	8	-	-	PUNCT
admet-286	240	9	points	point	NOUN
admet-286	240	10	(	(	PUNCT
admet-286	240	11	as	as	SCONJ
admet-286	240	12	described	describe	VERB
admet-286	240	13	previously	previously	ADV
admet-286	240	14	)	)	PUNCT
admet-286	240	15	were	be	AUX
admet-286	240	16	done	do	VERB
admet-286	240	17	based	base	VERB
admet-286	240	18	on	on	ADP
admet-286	240	19	the	the	DET
admet-286	240	20	auccomb	auccomb	NOUN
admet-286	240	21	and	and	CCONJ
admet-286	240	22	%	%	INTJ
admet-286	240	23	t	t	PROPN
admet-286	240	24	>	>	X
admet-286	240	25	miccomb	miccomb	PROPN
admet-286	240	26	values	value	NOUN
admet-286	240	27	which	which	PRON
admet-286	240	28	correlates	correlate	VERB
admet-286	240	29	best	well	ADV
admet-286	240	30	with	with	ADP
admet-286	240	31	maximal	maximal	ADJ
admet-286	240	32	bacterial	bacterial	ADJ
admet-286	240	33	killing	killing	NOUN
admet-286	240	34	effect	effect	NOUN
admet-286	240	35	(	(	PUNCT
admet-286	240	36	4	4	NUM
admet-286	240	37	fold	fold	ADJ
admet-286	240	38	log	log	NOUN
admet-286	240	39	reduction	reduction	NOUN
admet-286	240	40	in	in	ADP
admet-286	240	41	bacterial	bacterial	ADJ
admet-286	240	42	density	density	NOUN
admet-286	240	43	)	)	PUNCT
admet-286	240	44	.	.	PUNCT
admet-286	241	1	in	in	ADP
admet-286	241	2	the	the	DET
admet-286	241	3	present	present	ADJ
admet-286	241	4	study	study	NOUN
admet-286	241	5	,	,	PUNCT
admet-286	241	6	the	the	DET
admet-286	241	7	pta	pta	NOUN
admet-286	241	8	for	for	ADP
admet-286	241	9	auccomb	auccomb	NOUN
admet-286	241	10	admet	admet	PROPN
admet-286	241	11	&	&	CCONJ
admet-286	241	12	dmpk	dmpk	PROPN
admet-286	241	13	4(3	4(3	NUM
admet-286	241	14	)	)	PUNCT
admet-286	241	15	(	(	PUNCT
admet-286	241	16	2016	2016	NUM
admet-286	241	17	)	)	PUNCT
admet-286	241	18	241	241	NUM
admet-286	241	19	-	-	SYM
admet-286	241	20	260	260	NUM
admet-286	241	21	dose	dose	NOUN
admet-286	241	22	optimization	optimization	NOUN
admet-286	241	23	of	of	ADP
admet-286	241	24	fdc	fdc	PROPN
admet-286	241	25	against	against	ADP
admet-286	241	26	s.	s.	PROPN
admet-286	241	27	aureus	aureus	PROPN
admet-286	241	28	resistant	resistant	ADJ
admet-286	241	29	bacteria	bacteria	NOUN
admet-286	241	30	doi	doi	NOUN
admet-286	241	31	:	:	PUNCT
admet-286	241	32	10.5599	10.5599	NUM
admet-286	241	33	/	/	SYM
admet-286	241	34	admet.4.3.286	admet.4.3.286	ADJ
admet-286	241	35	253	253	NUM
admet-286	241	36	was	be	AUX
admet-286	241	37	defined	define	VERB
admet-286	241	38	as	as	ADP
admet-286	241	39	percentage	percentage	NOUN
admet-286	241	40	of	of	ADP
admet-286	241	41	the	the	DET
admet-286	241	42	simulated	simulate	VERB
admet-286	241	43	subjects	subject	NOUN
admet-286	241	44	in	in	ADP
admet-286	241	45	which	which	PRON
admet-286	241	46	auccomb	auccomb	NOUN
admet-286	241	47	was	be	AUX
admet-286	241	48	more	more	ADJ
admet-286	241	49	than	than	ADP
admet-286	241	50	400	400	NUM
admet-286	242	1	[	[	X
admet-286	242	2	2	2	NUM
admet-286	242	3	]	]	PUNCT
admet-286	242	4	.	.	PUNCT
admet-286	243	1	for	for	ADP
admet-286	243	2	%	%	PROPN
admet-286	243	3	t	t	PROPN
admet-286	243	4	>	>	X
admet-286	243	5	miccomb	miccomb	PROPN
admet-286	243	6	,	,	PUNCT
admet-286	243	7	the	the	DET
admet-286	243	8	pta	pta	NOUN
admet-286	243	9	was	be	AUX
admet-286	243	10	defined	define	VERB
admet-286	243	11	as	as	ADP
admet-286	243	12	percentage	percentage	NOUN
admet-286	243	13	of	of	ADP
admet-286	243	14	simulated	simulated	ADJ
admet-286	243	15	subjects	subject	NOUN
admet-286	243	16	showing	show	VERB
admet-286	243	17	%	%	PROPN
admet-286	243	18	t	t	PROPN
admet-286	243	19	>	>	X
admet-286	243	20	miccomb	miccomb	NOUN
admet-286	243	21	of	of	ADP
admet-286	243	22	more	more	ADJ
admet-286	243	23	than	than	ADP
admet-286	243	24	60	60	NUM
admet-286	243	25	.	.	PUNCT
admet-286	243	26	focusing	focus	VERB
admet-286	243	27	on	on	ADP
admet-286	243	28	pta	pta	NOUN
admet-286	243	29	of	of	ADP
admet-286	243	30	auccomb	auccomb	NOUN
admet-286	243	31	≥400	≥400	NOUN
admet-286	243	32	,	,	PUNCT
admet-286	243	33	ceftriaxone	ceftriaxone	PROPN
admet-286	243	34	/	/	SYM
admet-286	243	35	vancomycin	vancomycin	PROPN
admet-286	243	36	(	(	PUNCT
admet-286	243	37	2/1	2/1	NUM
admet-286	243	38	)	)	PUNCT
admet-286	243	39	had	have	AUX
admet-286	243	40	achieved	achieve	VERB
admet-286	243	41	almost	almost	ADV
admet-286	243	42	98	98	NUM
admet-286	243	43	%	%	NOUN
admet-286	243	44	pta	pta	NOUN
admet-286	243	45	for	for	ADP
admet-286	243	46	all	all	DET
admet-286	243	47	doses	dose	NOUN
admet-286	243	48	against	against	ADP
admet-286	243	49	the	the	DET
admet-286	243	50	strains	strain	NOUN
admet-286	243	51	for	for	ADP
admet-286	243	52	which	which	PRON
admet-286	243	53	it	it	PRON
admet-286	243	54	exhibits	exhibit	VERB
admet-286	243	55	mic	mic	NOUN
admet-286	243	56	of	of	ADP
admet-286	243	57	1	1	NUM
admet-286	243	58	µg	µg	NOUN
admet-286	243	59	/	/	SYM
admet-286	243	60	ml	ml	PROPN
admet-286	243	61	(	(	PUNCT
admet-286	243	62	figure	figure	NOUN
admet-286	243	63	7a	7a	NUM
admet-286	243	64	)	)	PUNCT
admet-286	243	65	.	.	PUNCT
admet-286	244	1	also	also	ADV
admet-286	244	2	for	for	ADP
admet-286	244	3	the	the	DET
admet-286	244	4	mic	mic	NOUN
admet-286	244	5	of	of	ADP
admet-286	244	6	4	4	NUM
admet-286	244	7	µg	µg	ADV
admet-286	244	8	/	/	SYM
admet-286	244	9	ml	ml	NOUN
admet-286	244	10	,	,	PUNCT
admet-286	244	11	the	the	DET
admet-286	244	12	lowest	low	ADJ
admet-286	244	13	dose	dose	NOUN
admet-286	244	14	that	that	PRON
admet-286	244	15	can	can	AUX
admet-286	244	16	achieve	achieve	VERB
admet-286	244	17	the	the	DET
admet-286	244	18	pta	pta	NOUN
admet-286	244	19	of	of	ADP
admet-286	244	20	more	more	ADJ
admet-286	244	21	than	than	ADP
admet-286	244	22	90	90	NUM
admet-286	244	23	%	%	NOUN
admet-286	244	24	was	be	AUX
admet-286	244	25	1.5	1.5	NUM
admet-286	244	26	g	g	ADP
admet-286	244	27	twice	twice	ADV
admet-286	244	28	dosing	dose	VERB
admet-286	244	29	.	.	PUNCT
admet-286	245	1	these	these	DET
admet-286	245	2	strains	strain	NOUN
admet-286	245	3	were	be	AUX
admet-286	245	4	categorized	categorize	VERB
admet-286	245	5	as	as	ADV
admet-286	245	6	susceptible	susceptible	ADJ
admet-286	245	7	to	to	ADP
admet-286	245	8	the	the	DET
admet-286	245	9	fdc	fdc	PROPN
admet-286	245	10	.	.	PUNCT
admet-286	246	1	further	further	ADJ
admet-286	246	2	increase	increase	VERB
admet-286	246	3	in	in	ADP
admet-286	246	4	mic	mic	ADJ
admet-286	246	5	i.e.	i.e.	X
admet-286	246	6	8	8	NUM
admet-286	246	7	µg	µg	ADV
admet-286	246	8	/	/	SYM
admet-286	246	9	ml	ml	VERB
admet-286	246	10	lowered	lower	VERB
admet-286	246	11	the	the	DET
admet-286	246	12	pta	pta	NOUN
admet-286	246	13	(	(	PUNCT
admet-286	246	14	31	31	NUM
admet-286	246	15	%	%	NOUN
admet-286	246	16	at	at	ADP
admet-286	246	17	1.5	1.5	NUM
admet-286	246	18	g	g	NOUN
admet-286	246	19	twice	twice	ADV
admet-286	246	20	-	-	PUNCT
admet-286	246	21	a	a	DET
admet-286	246	22	-	-	PUNCT
admet-286	246	23	day	day	NOUN
admet-286	246	24	)	)	PUNCT
admet-286	246	25	and	and	CCONJ
admet-286	246	26	could	could	AUX
admet-286	246	27	be	be	AUX
admet-286	246	28	improved	improve	VERB
admet-286	246	29	with	with	ADP
admet-286	246	30	higher	high	ADJ
admet-286	246	31	dose	dose	NOUN
admet-286	246	32	of	of	ADP
admet-286	246	33	the	the	DET
admet-286	246	34	fdc	fdc	PROPN
admet-286	246	35	(	(	PUNCT
admet-286	246	36	≈90	≈90	PROPN
admet-286	246	37	%	%	NOUN
admet-286	246	38	pta	pta	VERB
admet-286	246	39	at	at	ADP
admet-286	246	40	3.0	3.0	NUM
admet-286	246	41	g	g	NOUN
admet-286	246	42	twice	twice	ADV
admet-286	246	43	-	-	PUNCT
admet-286	246	44	a	a	DET
admet-286	246	45	-	-	PUNCT
admet-286	246	46	day	day	NOUN
admet-286	246	47	)	)	PUNCT
admet-286	246	48	.	.	PUNCT
admet-286	247	1	however	however	ADV
admet-286	247	2	,	,	PUNCT
admet-286	247	3	strains	strain	NOUN
admet-286	247	4	corresponding	correspond	VERB
admet-286	247	5	to	to	ADP
admet-286	247	6	mic	mic	NOUN
admet-286	247	7	of	of	ADP
admet-286	247	8	16	16	NUM
admet-286	247	9	,	,	PUNCT
admet-286	247	10	32	32	NUM
admet-286	247	11	and	and	CCONJ
admet-286	247	12	64	64	NUM
admet-286	247	13	µg	µg	ADV
admet-286	247	14	/	/	SYM
admet-286	247	15	ml	ml	VERB
admet-286	247	16	required	require	VERB
admet-286	247	17	large	large	ADJ
admet-286	247	18	amount	amount	NOUN
admet-286	247	19	of	of	ADP
admet-286	247	20	fdc	fdc	PROPN
admet-286	247	21	dose	dose	PROPN
admet-286	247	22	(	(	PUNCT
admet-286	247	23	>	>	SYM
admet-286	247	24	9	9	NUM
admet-286	247	25	g	g	NOUN
admet-286	247	26	)	)	PUNCT
admet-286	247	27	to	to	PART
admet-286	247	28	attain	attain	VERB
admet-286	247	29	moderate	moderate	ADJ
admet-286	247	30	pta	pta	NOUN
admet-286	247	31	(	(	PUNCT
admet-286	247	32	figure	figure	NOUN
admet-286	247	33	7a	7a	NUM
admet-286	247	34	)	)	PUNCT
admet-286	247	35	.	.	PUNCT
admet-286	248	1	these	these	DET
admet-286	248	2	strains	strain	NOUN
admet-286	248	3	were	be	AUX
admet-286	248	4	resistant	resistant	ADJ
admet-286	248	5	to	to	ADP
admet-286	248	6	the	the	DET
admet-286	248	7	therapeutic	therapeutic	ADJ
admet-286	248	8	dose	dose	NOUN
admet-286	248	9	of	of	ADP
admet-286	248	10	fdc	fdc	PROPN
admet-286	248	11	.	.	PUNCT
admet-286	249	1	figure	figure	VERB
admet-286	249	2	7	7	NUM
admet-286	249	3	.	.	PUNCT
admet-286	250	1	clinical	clinical	ADJ
admet-286	250	2	breakpoint	breakpoint	NOUN
admet-286	250	3	estimation	estimation	NOUN
admet-286	250	4	(	(	PUNCT
admet-286	250	5	a	a	DET
admet-286	250	6	,	,	PUNCT
admet-286	250	7	b	b	NOUN
admet-286	250	8	):	):	PUNCT
admet-286	250	9	monte	monte	PROPN
admet-286	250	10	carlo	carlo	PROPN
admet-286	250	11	simulations	simulation	NOUN
admet-286	250	12	for	for	ADP
admet-286	250	13	1000	1000	NUM
admet-286	250	14	subjects	subject	NOUN
admet-286	250	15	and	and	CCONJ
admet-286	250	16	pta	pta	NOUN
admet-286	250	17	of	of	ADP
admet-286	250	18	both	both	DET
admet-286	250	19	pk	pk	PROPN
admet-286	250	20	/	/	SYM
admet-286	250	21	pd	pd	PROPN
admet-286	250	22	indices	index	NOUN
admet-286	250	23	i.e.	i.e.	X
admet-286	250	24	auccomb	auccomb	NOUN
admet-286	250	25	(	(	PUNCT
admet-286	250	26	a	a	NOUN
admet-286	250	27	)	)	PUNCT
admet-286	250	28	and	and	CCONJ
admet-286	250	29	%	%	INTJ
admet-286	250	30	t	t	X
admet-286	250	31	>	>	X
admet-286	250	32	miccomb	miccomb	PROPN
admet-286	250	33	(	(	PUNCT
admet-286	250	34	b	b	NOUN
admet-286	250	35	)	)	PUNCT
admet-286	250	36	was	be	AUX
admet-286	250	37	evaluated	evaluate	VERB
admet-286	250	38	in	in	ADP
admet-286	250	39	the	the	DET
admet-286	250	40	simulated	simulate	VERB
admet-286	250	41	subjects	subject	NOUN
admet-286	250	42	.	.	PUNCT
admet-286	251	1	the	the	DET
admet-286	251	2	pta	pta	NOUN
admet-286	251	3	for	for	ADP
admet-286	251	4	auccomb	auccomb	NOUN
admet-286	251	5	was	be	AUX
admet-286	251	6	defined	define	VERB
admet-286	251	7	as	as	ADP
admet-286	251	8	percentage	percentage	NOUN
admet-286	251	9	of	of	ADP
admet-286	251	10	the	the	DET
admet-286	251	11	simulated	simulate	VERB
admet-286	251	12	patients	patient	NOUN
admet-286	251	13	in	in	ADP
admet-286	251	14	which	which	PRON
admet-286	251	15	auccomb	auccomb	NOUN
admet-286	251	16	was	be	AUX
admet-286	251	17	more	more	ADJ
admet-286	251	18	than	than	ADP
admet-286	251	19	400	400	NUM
admet-286	251	20	.	.	PUNCT
admet-286	252	1	similarly	similarly	ADV
admet-286	252	2	pta	pta	VERB
admet-286	252	3	for	for	ADP
admet-286	252	4	%	%	NOUN
admet-286	252	5	%	%	NOUN
admet-286	252	6	t	t	PROPN
admet-286	252	7	>	>	X
admet-286	252	8	miccomb	miccomb	PROPN
admet-286	252	9	was	be	AUX
admet-286	252	10	60	60	NUM
admet-286	252	11	.	.	PUNCT
admet-286	253	1	it	it	PRON
admet-286	253	2	was	be	AUX
admet-286	253	3	determined	determine	VERB
admet-286	253	4	that	that	SCONJ
admet-286	253	5	how	how	SCONJ
admet-286	253	6	likely	likely	ADV
admet-286	253	7	the	the	DET
admet-286	253	8	fdc	fdc	PROPN
admet-286	253	9	dose	dose	NOUN
admet-286	253	10	of	of	ADP
admet-286	253	11	0.75	0.75	NUM
admet-286	253	12	,	,	PUNCT
admet-286	253	13	1.5	1.5	NUM
admet-286	253	14	,	,	PUNCT
admet-286	253	15	3	3	NUM
admet-286	253	16	,	,	PUNCT
admet-286	253	17	6	6	NUM
admet-286	253	18	,	,	PUNCT
admet-286	253	19	and	and	CCONJ
admet-286	253	20	9	9	NUM
admet-286	253	21	gm	gm	PROPN
admet-286	253	22	would	would	AUX
admet-286	253	23	achieve	achieve	VERB
admet-286	253	24	auccomb	auccomb	NOUN
admet-286	253	25	/	/	SYM
admet-286	253	26	miccomb	miccomb	PROPN
admet-286	253	27	>	>	X
admet-286	253	28	400	400	NUM
admet-286	253	29	and	and	CCONJ
admet-286	253	30	60%t	60%t	NOUN
admet-286	253	31	>	>	X
admet-286	253	32	miccomb	miccomb	PROPN
admet-286	253	33	at	at	ADP
admet-286	253	34	different	different	ADJ
admet-286	253	35	values	value	NOUN
admet-286	253	36	of	of	ADP
admet-286	253	37	mic	mic	ADJ
admet-286	253	38	i.e.	i.e.	X
admet-286	253	39	1	1	NUM
admet-286	253	40	,	,	PUNCT
admet-286	253	41	4	4	NUM
admet-286	253	42	,	,	PUNCT
admet-286	253	43	8	8	NUM
admet-286	253	44	,	,	PUNCT
admet-286	253	45	16	16	NUM
admet-286	253	46	,	,	PUNCT
admet-286	253	47	3	3	NUM
admet-286	253	48	,	,	PUNCT
admet-286	253	49	64	64	NUM
admet-286	253	50	µg	µg	NOUN
admet-286	253	51	/	/	SYM
admet-286	253	52	ml	ml	NOUN
admet-286	253	53	.	.	PUNCT
admet-286	254	1	the	the	DET
admet-286	254	2	same	same	ADJ
admet-286	254	3	results	result	NOUN
admet-286	254	4	were	be	AUX
admet-286	254	5	mirrored	mirror	VERB
admet-286	254	6	with	with	ADP
admet-286	254	7	more	more	ADJ
admet-286	254	8	clarity	clarity	NOUN
admet-286	254	9	in	in	ADP
admet-286	254	10	%	%	PROPN
admet-286	254	11	t	t	PROPN
admet-286	254	12	>	>	X
admet-286	254	13	miccomb	miccomb	PROPN
admet-286	254	14	based	base	VERB
admet-286	254	15	monte	monte	PROPN
admet-286	254	16	carlo	carlo	PROPN
admet-286	254	17	simulations	simulation	NOUN
admet-286	254	18	(	(	PUNCT
admet-286	254	19	figure	figure	NOUN
admet-286	254	20	7b	7b	NOUN
admet-286	254	21	)	)	PUNCT
admet-286	254	22	.	.	PUNCT
admet-286	255	1	it	it	PRON
admet-286	255	2	must	must	AUX
admet-286	255	3	be	be	AUX
admet-286	255	4	mentioned	mention	VERB
admet-286	255	5	that	that	SCONJ
admet-286	255	6	the	the	DET
admet-286	255	7	pk	pk	PROPN
admet-286	255	8	/	/	SYM
admet-286	255	9	pd	pd	NOUN
admet-286	255	10	index	index	NOUN
admet-286	255	11	i.e.	i.e.	X
admet-286	255	12	%	%	ADP
admet-286	255	13	t	t	PROPN
admet-286	255	14	>	>	X
admet-286	255	15	miccomb	miccomb	PROPN
admet-286	255	16	was	be	AUX
admet-286	255	17	best	good	ADJ
admet-286	255	18	pk	pk	PROPN
admet-286	255	19	/	/	SYM
admet-286	255	20	pd	pd	PROPN
admet-286	255	21	driver	driver	NOUN
admet-286	255	22	for	for	ADP
admet-286	255	23	fdc	fdc	PROPN
admet-286	255	24	.	.	PUNCT
admet-286	256	1	as	as	SCONJ
admet-286	256	2	shown	show	VERB
admet-286	256	3	in	in	ADP
admet-286	256	4	figure	figure	NOUN
admet-286	256	5	7b	7b	NOUN
admet-286	256	6	,	,	PUNCT
admet-286	256	7	the	the	DET
admet-286	256	8	combination	combination	NOUN
admet-286	256	9	was	be	AUX
admet-286	256	10	very	very	ADV
admet-286	256	11	effective	effective	ADJ
admet-286	256	12	with	with	ADP
admet-286	256	13	pta	pta	NOUN
admet-286	256	14	of	of	ADP
admet-286	256	15	≈99	≈99	PROPN
admet-286	256	16	%	%	NOUN
admet-286	256	17	at	at	ADP
admet-286	256	18	all	all	DET
admet-286	256	19	dose	dose	NOUN
admet-286	256	20	strengths	strength	NOUN
admet-286	256	21	,	,	PUNCT
admet-286	256	22	for	for	ADP
admet-286	256	23	the	the	DET
admet-286	256	24	strains	strain	NOUN
admet-286	256	25	corresponding	correspond	VERB
admet-286	256	26	to	to	ADP
admet-286	256	27	mic	mic	NOUN
admet-286	256	28	of	of	ADP
admet-286	256	29	1	1	NUM
admet-286	256	30	and	and	CCONJ
admet-286	256	31	4	4	NUM
admet-286	256	32	µg	µg	ADV
admet-286	256	33	/	/	SYM
admet-286	256	34	ml	ml	NOUN
admet-286	256	35	.	.	PUNCT
admet-286	257	1	for	for	ADP
admet-286	257	2	mic	mic	NOUN
admet-286	257	3	of	of	ADP
admet-286	257	4	8	8	NUM
admet-286	257	5	and	and	CCONJ
admet-286	257	6	16	16	NUM
admet-286	257	7	µg	µg	ADJ
admet-286	257	8	/	/	SYM
admet-286	257	9	ml	ml	NOUN
admet-286	257	10	,	,	PUNCT
admet-286	257	11	higher	high	ADJ
admet-286	257	12	dose	dose	NOUN
admet-286	257	13	of	of	ADP
admet-286	257	14	fdc	fdc	PROPN
admet-286	257	15	was	be	AUX
admet-286	257	16	required	require	VERB
admet-286	257	17	to	to	PART
admet-286	257	18	revive	revive	VERB
admet-286	257	19	its	its	PRON
admet-286	257	20	efficacy	efficacy	NOUN
admet-286	257	21	against	against	ADP
admet-286	257	22	the	the	DET
admet-286	257	23	bacterial	bacterial	ADJ
admet-286	257	24	infection	infection	NOUN
admet-286	257	25	.	.	PUNCT
admet-286	258	1	interestingly	interestingly	ADV
admet-286	258	2	,	,	PUNCT
admet-286	258	3	the	the	DET
admet-286	258	4	pd	pd	ADJ
admet-286	258	5	effect	effect	NOUN
admet-286	258	6	against	against	ADP
admet-286	258	7	the	the	DET
admet-286	258	8	strains	strain	NOUN
admet-286	258	9	of	of	ADP
admet-286	258	10	mic	mic	NOUN
admet-286	258	11	of	of	ADP
admet-286	258	12	8	8	NUM
admet-286	258	13	µg	µg	NOUN
admet-286	258	14	/	/	SYM
admet-286	258	15	ml	ml	NOUN
admet-286	258	16	,	,	PUNCT
admet-286	258	17	was	be	AUX
admet-286	258	18	tilted	tilt	VERB
admet-286	258	19	more	more	ADV
admet-286	258	20	toward	toward	ADP
admet-286	258	21	susceptible	susceptible	ADJ
admet-286	258	22	range	range	NOUN
admet-286	258	23	of	of	ADP
admet-286	258	24	mic	mic	ADJ
admet-286	258	25	(	(	PUNCT
admet-286	258	26	1	1	NUM
admet-286	258	27	and	and	CCONJ
admet-286	258	28	4	4	NUM
admet-286	258	29	µg	µg	ADV
admet-286	258	30	/	/	SYM
admet-286	258	31	ml	ml	NOUN
admet-286	258	32	)	)	PUNCT
admet-286	258	33	,	,	PUNCT
admet-286	258	34	whereas	whereas	SCONJ
admet-286	258	35	strains	strain	NOUN
admet-286	258	36	corresponding	correspond	VERB
admet-286	258	37	to	to	ADP
admet-286	258	38	mic	mic	NOUN
admet-286	258	39	of	of	ADP
admet-286	258	40	16	16	NUM
admet-286	258	41	µg	µg	NOUN
admet-286	258	42	/	/	SYM
admet-286	258	43	ml	ml	NOUN
admet-286	258	44	was	be	AUX
admet-286	258	45	closer	close	ADJ
admet-286	258	46	to	to	ADP
admet-286	258	47	resistant	resistant	ADJ
admet-286	258	48	ones	one	NOUN
admet-286	258	49	.	.	PUNCT
admet-286	259	1	following	follow	VERB
admet-286	259	2	the	the	DET
admet-286	259	3	same	same	ADJ
admet-286	259	4	trend	trend	NOUN
admet-286	259	5	observed	observe	VERB
admet-286	259	6	in	in	ADP
admet-286	259	7	case	case	NOUN
admet-286	259	8	of	of	ADP
admet-286	259	9	auccomb	auccomb	NOUN
admet-286	259	10	(	(	PUNCT
admet-286	259	11	figure	figure	NOUN
admet-286	259	12	7a	7a	NUM
admet-286	259	13	)	)	PUNCT
admet-286	259	14	,	,	PUNCT
admet-286	259	15	the	the	DET
admet-286	259	16	fdc	fdc	PROPN
admet-286	259	17	was	be	AUX
admet-286	259	18	ineffective	ineffective	ADJ
admet-286	259	19	at	at	ADP
admet-286	259	20	all	all	DET
admet-286	259	21	drug	drug	NOUN
admet-286	259	22	exposures	exposure	NOUN
admet-286	259	23	for	for	ADP
admet-286	259	24	the	the	DET
admet-286	259	25	mic	mic	NOUN
admet-286	259	26	of	of	ADP
admet-286	259	27	32	32	NUM
admet-286	259	28	and	and	CCONJ
admet-286	259	29	64	64	NUM
admet-286	259	30	µg	µg	NOUN
admet-286	259	31	/	/	SYM
admet-286	259	32	ml	ml	NOUN
admet-286	259	33	.	.	PUNCT
admet-286	260	1	for	for	ADP
admet-286	260	2	these	these	DET
admet-286	260	3	resistant	resistant	ADJ
admet-286	260	4	strains	strain	NOUN
admet-286	260	5	,	,	PUNCT
admet-286	260	6	standard	standard	ADJ
admet-286	260	7	dose	dose	NOUN
admet-286	260	8	of	of	ADP
admet-286	260	9	1.5	1.5	NUM
admet-286	260	10	g	g	NOUN
admet-286	260	11	and	and	CCONJ
admet-286	260	12	3.0	3.0	NUM
admet-286	260	13	g	g	NOUN
admet-286	260	14	twice	twice	ADV
admet-286	260	15	-	-	PUNCT
admet-286	260	16	a	a	DET
admet-286	260	17	-	-	PUNCT
admet-286	260	18	dose	dose	NOUN
admet-286	260	19	were	be	AUX
admet-286	260	20	sub	sub	ADJ
admet-286	260	21	-	-	ADJ
admet-286	260	22	optimal	optimal	ADJ
admet-286	260	23	and	and	CCONJ
admet-286	260	24	higher	high	ADJ
admet-286	260	25	doses	dose	NOUN
admet-286	260	26	were	be	AUX
admet-286	260	27	needed	need	VERB
admet-286	260	28	to	to	PART
admet-286	260	29	achieve	achieve	VERB
admet-286	260	30	the	the	DET
admet-286	260	31	antibacterial	antibacterial	ADJ
admet-286	260	32	effect	effect	NOUN
admet-286	260	33	.	.	PUNCT
admet-286	261	1	thus	thus	ADV
admet-286	261	2	,	,	PUNCT
admet-286	261	3	the	the	DET
admet-286	261	4	strains	strain	NOUN
admet-286	261	5	corresponding	correspond	VERB
admet-286	261	6	to	to	ADP
admet-286	261	7	the	the	DET
admet-286	261	8	mic	mic	NOUN
admet-286	261	9	of	of	ADP
admet-286	261	10	1	1	NUM
admet-286	261	11	-	-	SYM
admet-286	261	12	4	4	NUM
admet-286	261	13	µg	µg	NOUN
admet-286	261	14	/	/	SYM
admet-286	261	15	ml	ml	NOUN
admet-286	261	16	,	,	PUNCT
admet-286	261	17	8	8	NUM
admet-286	261	18	-	-	SYM
admet-286	261	19	16	16	NUM
admet-286	261	20	µg	µg	NOUN
admet-286	261	21	/	/	SYM
admet-286	261	22	ml	ml	NOUN
admet-286	261	23	and	and	CCONJ
admet-286	261	24	32	32	NUM
admet-286	261	25	-	-	SYM
admet-286	261	26	64	64	NUM
admet-286	261	27	µg	µg	NOUN
admet-286	261	28	/	/	SYM
admet-286	261	29	ml	ml	NOUN
admet-286	261	30	were	be	AUX
admet-286	261	31	susceptible	susceptible	ADJ
admet-286	261	32	,	,	PUNCT
admet-286	261	33	intermediate	intermediate	ADJ
admet-286	261	34	and	and	CCONJ
admet-286	261	35	resistant	resistant	ADJ
admet-286	261	36	respectively	respectively	ADV
admet-286	261	37	to	to	ADP
admet-286	261	38	the	the	DET
admet-286	261	39	fdc	fdc	PROPN
admet-286	261	40	of	of	ADP
admet-286	261	41	ceftriaxone	ceftriaxone	PROPN
admet-286	261	42	/	/	SYM
admet-286	261	43	vancomycin	vancomycin	PROPN
admet-286	261	44	(	(	PUNCT
admet-286	261	45	2/1	2/1	NUM
admet-286	261	46	)	)	PUNCT
admet-286	261	47	.	.	PUNCT
admet-286	262	1	this	this	DET
admet-286	262	2	categorization	categorization	NOUN
admet-286	262	3	is	be	AUX
admet-286	262	4	also	also	ADV
admet-286	262	5	defined	define	VERB
admet-286	262	6	as	as	ADP
admet-286	262	7	clinical	clinical	ADJ
admet-286	262	8	breakpoints	breakpoint	NOUN
admet-286	262	9	,	,	PUNCT
admet-286	262	10	which	which	PRON
admet-286	262	11	separates	separate	VERB
admet-286	262	12	resistant	resistant	ADJ
admet-286	262	13	bacterial	bacterial	ADJ
admet-286	262	14	strains	strain	NOUN
admet-286	262	15	from	from	ADP
admet-286	262	16	the	the	DET
admet-286	262	17	sensitive	sensitive	ADJ
admet-286	262	18	ones	one	NOUN
admet-286	262	19	against	against	ADP
admet-286	262	20	a	a	DET
admet-286	262	21	drug	drug	NOUN
admet-286	262	22	in	in	ADP
admet-286	262	23	terms	term	NOUN
admet-286	262	24	of	of	ADP
admet-286	262	25	its	its	PRON
admet-286	262	26	mic	mic	ADJ
admet-286	262	27	values	value	NOUN
admet-286	262	28	.	.	PUNCT
admet-286	263	1	the	the	DET
admet-286	263	2	clinical	clinical	ADJ
admet-286	263	3	breakpoints	breakpoint	NOUN
admet-286	263	4	obtained	obtain	VERB
admet-286	263	5	from	from	ADP
admet-286	263	6	monte	monte	PROPN
admet-286	263	7	carlo	carlo	PROPN
admet-286	263	8	simulation	simulation	PROPN
admet-286	263	9	,	,	PUNCT
admet-286	263	10	were	be	AUX
admet-286	263	11	compared	compare	VERB
admet-286	263	12	with	with	ADP
admet-286	263	13	mic	mic	ADJ
admet-286	263	14	breakpoints	breakpoint	NOUN
admet-286	263	15	obtained	obtain	VERB
admet-286	263	16	from	from	ADP
admet-286	263	17	in	in	ADP
admet-286	263	18	-	-	PUNCT
admet-286	263	19	house	house	NOUN
admet-286	263	20	study	study	NOUN
admet-286	263	21	on	on	ADP
admet-286	263	22	500	500	NUM
admet-286	263	23	clinical	clinical	ADJ
admet-286	263	24	isolates	isolate	NOUN
admet-286	263	25	of	of	ADP
admet-286	263	26	mrsa	mrsa	NOUN
admet-286	263	27	(	(	PUNCT
admet-286	263	28	mic	mic	ADJ
admet-286	263	29	and	and	CCONJ
admet-286	263	30	ast	ast	NOUN
admet-286	263	31	breakpoint	breakpoint	NOUN
admet-286	263	32	estimation	estimation	NOUN
admet-286	263	33	;	;	PUNCT
admet-286	263	34	table	table	NOUN
admet-286	263	35	-	-	PUNCT
admet-286	263	36	s2	s2	NOUN
admet-286	263	37	)	)	PUNCT
admet-286	263	38	.	.	PUNCT
admet-286	264	1	the	the	DET
admet-286	264	2	results	result	NOUN
admet-286	264	3	were	be	AUX
admet-286	264	4	in	in	ADP
admet-286	264	5	agreement	agreement	NOUN
admet-286	264	6	with	with	ADP
admet-286	264	7	each	each	DET
admet-286	264	8	other	other	ADJ
admet-286	264	9	,	,	PUNCT
admet-286	264	10	suggesting	suggest	VERB
admet-286	264	11	promising	promise	VERB
admet-286	264	12	outcomes	outcome	NOUN
admet-286	264	13	in	in	ADP
admet-286	264	14	future	future	ADJ
admet-286	264	15	clinical	clinical	ADJ
admet-286	264	16	studies	study	NOUN
admet-286	264	17	of	of	ADP
admet-286	264	18	the	the	DET
admet-286	264	19	fdc	fdc	PROPN
admet-286	264	20	ceftriaxone	ceftriaxone	PROPN
admet-286	264	21	/	/	SYM
admet-286	264	22	vancomycin	vancomycin	PROPN
admet-286	264	23	(	(	PUNCT
admet-286	264	24	2/1	2/1	NUM
admet-286	264	25	)	)	PUNCT
admet-286	264	26	.	.	PUNCT
admet-286	265	1	these	these	DET
admet-286	265	2	clinical	clinical	ADJ
admet-286	265	3	breakpoints	breakpoint	NOUN
admet-286	265	4	give	give	VERB
admet-286	265	5	a	a	DET
admet-286	265	6	significant	significant	ADJ
admet-286	265	7	advantage	advantage	NOUN
admet-286	265	8	over	over	ADP
admet-286	265	9	infections	infection	NOUN
admet-286	265	10	wherein	wherein	SCONJ
admet-286	265	11	vancomycin	vancomycin	PROPN
admet-286	265	12	alone	alone	ADV
admet-286	265	13	is	be	AUX
admet-286	265	14	vishnu	vishnu	ADJ
admet-286	265	15	sharma	sharma	PROPN
admet-286	265	16	et	et	PROPN
admet-286	265	17	al	al	PROPN
admet-286	265	18	.	.	PROPN
admet-286	265	19	admet	admet	PROPN
admet-286	265	20	&	&	CCONJ
admet-286	265	21	dmpk	dmpk	PROPN
admet-286	265	22	4(3	4(3	NUM
admet-286	265	23	)	)	PUNCT
admet-286	265	24	(	(	PUNCT
admet-286	265	25	2016	2016	NUM
admet-286	265	26	)	)	PUNCT
admet-286	265	27	241	241	NUM
admet-286	265	28	-	-	SYM
admet-286	265	29	260	260	NUM
admet-286	265	30	254	254	NUM
admet-286	265	31	showing	show	VERB
admet-286	265	32	therapeutic	therapeutic	ADJ
admet-286	265	33	limitations	limitation	NOUN
admet-286	265	34	.	.	PUNCT
admet-286	266	1	for	for	ADP
admet-286	266	2	example	example	NOUN
admet-286	266	3	the	the	DET
admet-286	266	4	susceptibility	susceptibility	NOUN
admet-286	266	5	of	of	ADP
admet-286	266	6	mrsa	mrsa	NOUN
admet-286	266	7	for	for	ADP
admet-286	266	8	fdc	fdc	PROPN
admet-286	266	9	(	(	PUNCT
admet-286	266	10	vancomycin	vancomycin	PROPN
admet-286	266	11	+	+	CCONJ
admet-286	266	12	ceftriaxone	ceftriaxone	PROPN
admet-286	266	13	)	)	PUNCT
admet-286	266	14	is	be	AUX
admet-286	266	15	2	2	NUM
admet-286	266	16	fold	fold	NOUN
admet-286	266	17	higher	higher	ADV
admet-286	266	18	than	than	ADP
admet-286	266	19	vancomycin	vancomycin	PROPN
admet-286	266	20	(	(	PUNCT
admet-286	266	21	mic	mic	ADJ
admet-286	266	22	≤	≤	ADV
admet-286	266	23	4	4	NUM
admet-286	266	24	µg	µg	NOUN
admet-286	266	25	/	/	SYM
admet-286	266	26	ml	ml	NOUN
admet-286	266	27	for	for	ADP
admet-286	266	28	fdc	fdc	PROPN
admet-286	266	29	and	and	CCONJ
admet-286	266	30	≤2	≤2	AUX
admet-286	266	31	µg	µg	NOUN
admet-286	266	32	/	/	SYM
admet-286	266	33	ml	ml	NOUN
admet-286	266	34	for	for	ADP
admet-286	266	35	vancomycin	vancomycin	PROPN
admet-286	266	36	)	)	PUNCT
admet-286	266	37	alone	alone	ADV
admet-286	266	38	.	.	PUNCT
admet-286	267	1	in	in	ADP
admet-286	267	2	addition	addition	NOUN
admet-286	267	3	to	to	ADP
admet-286	267	4	mrsa	mrsa	NOUN
admet-286	267	5	susceptibility	susceptibility	NOUN
admet-286	267	6	,	,	PUNCT
admet-286	267	7	the	the	DET
admet-286	267	8	fdc	fdc	PROPN
admet-286	267	9	provides	provide	VERB
admet-286	267	10	broader	broad	ADJ
admet-286	267	11	antibacterial	antibacterial	ADJ
admet-286	267	12	coverage	coverage	NOUN
admet-286	267	13	(	(	PUNCT
admet-286	267	14	active	active	ADJ
admet-286	267	15	against	against	ADP
admet-286	267	16	both	both	DET
admet-286	267	17	gram	gram	NOUN
admet-286	267	18	positive	positive	ADJ
admet-286	267	19	and	and	CCONJ
admet-286	267	20	negative	negative	ADJ
admet-286	267	21	bacteria	bacteria	NOUN
admet-286	267	22	)	)	PUNCT
admet-286	267	23	.	.	PUNCT
admet-286	268	1	the	the	DET
admet-286	268	2	better	well	ADV
admet-286	268	3	clinical	clinical	ADJ
admet-286	268	4	reach	reach	NOUN
admet-286	268	5	will	will	AUX
admet-286	268	6	help	help	VERB
admet-286	268	7	in	in	ADP
admet-286	268	8	tackling	tackle	VERB
admet-286	268	9	vancomycin	vancomycin	PROPN
admet-286	268	10	mediated	mediate	VERB
admet-286	268	11	resistance	resistance	NOUN
admet-286	268	12	more	more	ADV
admet-286	268	13	effectively	effectively	ADV
admet-286	268	14	.	.	PUNCT
admet-286	269	1	the	the	DET
admet-286	269	2	cost	cost	NOUN
admet-286	269	3	-	-	PUNCT
admet-286	269	4	effectiveness	effectiveness	NOUN
admet-286	269	5	study	study	NOUN
admet-286	269	6	of	of	ADP
admet-286	269	7	the	the	DET
admet-286	269	8	fdc	fdc	PROPN
admet-286	269	9	with	with	ADP
admet-286	269	10	respect	respect	NOUN
admet-286	269	11	to	to	ADP
admet-286	269	12	other	other	ADJ
admet-286	269	13	commercially	commercially	ADV
admet-286	269	14	available	available	ADJ
admet-286	269	15	antibiotics	antibiotic	NOUN
admet-286	269	16	is	be	AUX
admet-286	269	17	currently	currently	ADV
admet-286	269	18	under	under	ADP
admet-286	269	19	investigation	investigation	NOUN
admet-286	269	20	,	,	PUNCT
admet-286	269	21	as	as	SCONJ
admet-286	269	22	previously	previously	ADV
admet-286	269	23	done	do	VERB
admet-286	269	24	by	by	ADP
admet-286	269	25	sharma	sharma	PROPN
admet-286	269	26	et	et	PROPN
admet-286	269	27	al	al	PROPN
admet-286	269	28	.	.	PROPN
admet-286	270	1	on	on	ADP
admet-286	270	2	similar	similar	ADJ
admet-286	270	3	fdcs	fdc	NOUN
admet-286	271	1	[	[	X
admet-286	271	2	38	38	NUM
admet-286	271	3	]	]	PUNCT
admet-286	271	4	.	.	PUNCT
admet-286	272	1	our	our	PRON
admet-286	272	2	study	study	NOUN
admet-286	272	3	mainly	mainly	ADV
admet-286	272	4	focused	focus	VERB
admet-286	272	5	on	on	ADP
admet-286	272	6	in	in	ADP
admet-286	272	7	vitro	vitro	X
admet-286	272	8	pk	pk	PROPN
admet-286	272	9	/	/	SYM
admet-286	272	10	pd	pd	NOUN
admet-286	272	11	relationships	relationship	NOUN
admet-286	272	12	of	of	ADP
admet-286	272	13	fdc	fdc	PROPN
admet-286	272	14	antibiotics	antibiotic	NOUN
admet-286	272	15	,	,	PUNCT
admet-286	272	16	however	however	ADV
admet-286	272	17	generalizing	generalize	VERB
admet-286	272	18	the	the	DET
admet-286	272	19	inferences	inference	NOUN
admet-286	272	20	of	of	ADP
admet-286	272	21	this	this	DET
admet-286	272	22	study	study	NOUN
admet-286	272	23	to	to	ADP
admet-286	272	24	all	all	DET
admet-286	272	25	fdc	fdc	PROPN
admet-286	272	26	antibiotics	antibiotic	NOUN
admet-286	272	27	will	will	AUX
admet-286	272	28	not	not	PART
admet-286	272	29	be	be	AUX
admet-286	272	30	prudent	prudent	ADJ
admet-286	272	31	.	.	PUNCT
admet-286	273	1	also	also	ADV
admet-286	273	2	,	,	PUNCT
admet-286	273	3	the	the	DET
admet-286	273	4	in	in	ADP
admet-286	273	5	vitro	vitro	NOUN
admet-286	273	6	-	-	PUNCT
admet-286	273	7	in	in	ADP
admet-286	273	8	vivo	vivo	NOUN
admet-286	273	9	translation	translation	NOUN
admet-286	273	10	,	,	PUNCT
admet-286	273	11	and	and	CCONJ
admet-286	273	12	finally	finally	ADV
admet-286	273	13	its	its	PRON
admet-286	273	14	applicability	applicability	NOUN
admet-286	273	15	in	in	ADP
admet-286	273	16	clinical	clinical	ADJ
admet-286	273	17	settings	setting	NOUN
admet-286	273	18	still	still	ADV
admet-286	273	19	needs	need	VERB
admet-286	273	20	to	to	PART
admet-286	273	21	be	be	AUX
admet-286	273	22	evaluated	evaluate	VERB
admet-286	273	23	.	.	PUNCT
admet-286	274	1	we	we	PRON
admet-286	274	2	have	have	AUX
admet-286	274	3	focused	focus	VERB
admet-286	274	4	on	on	ADP
admet-286	274	5	only	only	ADV
admet-286	274	6	one	one	NUM
admet-286	274	7	bacterial	bacterial	ADJ
admet-286	274	8	isolate	isolate	NOUN
admet-286	274	9	,	,	PUNCT
admet-286	274	10	and	and	CCONJ
admet-286	274	11	we	we	PRON
admet-286	274	12	understand	understand	VERB
admet-286	274	13	that	that	SCONJ
admet-286	274	14	when	when	SCONJ
admet-286	274	15	more	more	ADJ
admet-286	274	16	clinical	clinical	ADJ
admet-286	274	17	isolates	isolate	NOUN
admet-286	274	18	with	with	ADP
admet-286	274	19	different	different	ADJ
admet-286	274	20	resistance	resistance	NOUN
admet-286	274	21	patterns	pattern	NOUN
admet-286	274	22	will	will	AUX
admet-286	274	23	be	be	AUX
admet-286	274	24	studied	study	VERB
admet-286	274	25	,	,	PUNCT
admet-286	274	26	the	the	DET
admet-286	274	27	exposure	exposure	NOUN
admet-286	274	28	targets	target	NOUN
admet-286	274	29	may	may	AUX
admet-286	274	30	get	get	AUX
admet-286	274	31	modified	modify	VERB
admet-286	274	32	.	.	PUNCT
admet-286	275	1	however	however	ADV
admet-286	275	2	,	,	PUNCT
admet-286	275	3	the	the	DET
admet-286	275	4	results	result	NOUN
admet-286	275	5	of	of	ADP
admet-286	275	6	this	this	DET
admet-286	275	7	study	study	NOUN
admet-286	275	8	not	not	PART
admet-286	275	9	only	only	ADV
admet-286	275	10	give	give	VERB
admet-286	275	11	the	the	DET
admet-286	275	12	starting	starting	NOUN
admet-286	275	13	point	point	NOUN
admet-286	275	14	to	to	PART
admet-286	275	15	use	use	VERB
admet-286	275	16	the	the	DET
admet-286	275	17	fdc	fdc	PROPN
admet-286	275	18	clinically	clinically	ADV
admet-286	275	19	but	but	CCONJ
admet-286	275	20	will	will	AUX
admet-286	275	21	also	also	ADV
admet-286	275	22	refine	refine	VERB
admet-286	275	23	the	the	DET
admet-286	275	24	clinical	clinical	ADJ
admet-286	275	25	study	study	NOUN
admet-286	275	26	and	and	CCONJ
admet-286	275	27	design	design	NOUN
admet-286	275	28	for	for	ADP
admet-286	275	29	further	further	ADJ
admet-286	275	30	clinical	clinical	ADJ
admet-286	275	31	research	research	NOUN
admet-286	275	32	work	work	NOUN
admet-286	275	33	.	.	PUNCT
admet-286	276	1	conclusions	conclusion	NOUN
admet-286	276	2	to	to	PART
admet-286	276	3	summarize	summarize	VERB
admet-286	276	4	,	,	PUNCT
admet-286	276	5	in	in	ADP
admet-286	276	6	vitro	vitro	X
admet-286	276	7	system	system	NOUN
admet-286	276	8	was	be	AUX
admet-286	276	9	used	use	VERB
admet-286	276	10	to	to	PART
admet-286	276	11	estimate	estimate	VERB
admet-286	276	12	pk	pk	NOUN
admet-286	276	13	parameters	parameter	NOUN
admet-286	276	14	and	and	CCONJ
admet-286	276	15	pd	pd	NOUN
admet-286	276	16	effects	effect	NOUN
admet-286	276	17	for	for	ADP
admet-286	276	18	different	different	ADJ
admet-286	276	19	exposure	exposure	NOUN
admet-286	276	20	of	of	ADP
admet-286	276	21	the	the	DET
admet-286	276	22	fdc	fdc	PROPN
admet-286	276	23	of	of	ADP
admet-286	276	24	ceftriaxone	ceftriaxone	PROPN
admet-286	276	25	/	/	SYM
admet-286	276	26	vancomycin	vancomycin	PROPN
admet-286	276	27	(	(	PUNCT
admet-286	276	28	2/1	2/1	NUM
admet-286	276	29	)	)	PUNCT
admet-286	276	30	.	.	PUNCT
admet-286	277	1	the	the	DET
admet-286	277	2	best	good	ADJ
admet-286	277	3	antibacterial	antibacterial	ADJ
admet-286	277	4	effect	effect	NOUN
admet-286	277	5	was	be	AUX
admet-286	277	6	obtained	obtain	VERB
admet-286	277	7	from	from	ADP
admet-286	277	8	the	the	DET
admet-286	277	9	exposure	exposure	NOUN
admet-286	277	10	of	of	ADP
admet-286	277	11	50x	50x	NUM
admet-286	277	12	miccomb	miccomb	NOUN
admet-286	277	13	which	which	PRON
admet-286	277	14	when	when	SCONJ
admet-286	277	15	fractioned	fraction	VERB
admet-286	277	16	to	to	PART
admet-286	277	17	twice	twice	ADV
admet-286	277	18	-	-	PUNCT
admet-286	277	19	daily	daily	NOUN
admet-286	277	20	dosing	dosing	NOUN
admet-286	277	21	showed	show	VERB
admet-286	277	22	maximum	maximum	ADJ
admet-286	277	23	reduction	reduction	NOUN
admet-286	277	24	in	in	ADP
admet-286	277	25	bacterial	bacterial	ADJ
admet-286	277	26	densities	density	NOUN
admet-286	277	27	.	.	PUNCT
admet-286	278	1	the	the	DET
admet-286	278	2	semi	semi	ADJ
admet-286	278	3	-	-	ADJ
admet-286	278	4	mechanistic	mechanistic	ADJ
admet-286	278	5	pk	pk	NOUN
admet-286	278	6	/	/	SYM
admet-286	278	7	pd	pd	NOUN
admet-286	278	8	model	model	NOUN
admet-286	278	9	incorporating	incorporate	VERB
admet-286	278	10	bacterial	bacterial	ADJ
admet-286	278	11	kinetics	kinetic	NOUN
admet-286	278	12	and	and	CCONJ
admet-286	278	13	drug	drug	NOUN
admet-286	278	14	’s	’s	PART
admet-286	278	15	pk	pk	PROPN
admet-286	278	16	/	/	SYM
admet-286	278	17	pd	pd	PROPN
admet-286	278	18	relationship	relationship	NOUN
admet-286	278	19	showed	show	VERB
admet-286	278	20	good	good	ADJ
admet-286	278	21	predictability	predictability	NOUN
admet-286	278	22	(	(	PUNCT
admet-286	278	23	very	very	ADV
admet-286	278	24	week	week	NOUN
admet-286	278	25	predictability	predictability	NOUN
admet-286	278	26	at	at	ADP
admet-286	278	27	lower	low	ADJ
admet-286	278	28	exposures	exposure	NOUN
admet-286	278	29	)	)	PUNCT
admet-286	278	30	at	at	ADP
admet-286	278	31	therapeutic	therapeutic	ADJ
admet-286	278	32	exposures	exposure	NOUN
admet-286	278	33	.	.	PUNCT
admet-286	279	1	taking	take	VERB
admet-286	279	2	into	into	ADP
admet-286	279	3	the	the	DET
admet-286	279	4	consideration	consideration	NOUN
admet-286	279	5	the	the	DET
admet-286	279	6	randomness	randomness	NOUN
admet-286	279	7	and	and	CCONJ
admet-286	279	8	pk	pk	NOUN
admet-286	279	9	variability	variability	NOUN
admet-286	279	10	of	of	ADP
admet-286	279	11	subjects	subject	NOUN
admet-286	279	12	,	,	PUNCT
admet-286	279	13	monte	monte	PROPN
admet-286	279	14	carlo	carlo	PROPN
admet-286	279	15	simulations	simulation	NOUN
admet-286	279	16	revealed	reveal	VERB
admet-286	279	17	that	that	SCONJ
admet-286	279	18	clinical	clinical	ADJ
admet-286	279	19	breakpoints	breakpoint	NOUN
admet-286	279	20	of	of	ADP
admet-286	279	21	fdc	fdc	PROPN
admet-286	279	22	for	for	ADP
admet-286	279	23	susceptible	susceptible	ADJ
admet-286	279	24	,	,	PUNCT
admet-286	279	25	intermediate	intermediate	ADJ
admet-286	279	26	and	and	CCONJ
admet-286	279	27	resistant	resistant	ADJ
admet-286	279	28	strains	strain	NOUN
admet-286	279	29	were	be	AUX
admet-286	279	30	≤	≤	NUM
admet-286	279	31	4	4	NUM
admet-286	279	32	,	,	PUNCT
admet-286	279	33	8	8	NUM
admet-286	279	34	-	-	SYM
admet-286	279	35	16	16	NUM
admet-286	279	36	,	,	PUNCT
admet-286	279	37	and	and	CCONJ
admet-286	279	38	≥	≥	NUM
admet-286	279	39	32	32	NUM
admet-286	279	40	µg	µg	NOUN
admet-286	279	41	/	/	SYM
admet-286	279	42	ml	ml	NOUN
admet-286	279	43	,	,	PUNCT
admet-286	279	44	respectively	respectively	ADV
admet-286	279	45	.	.	PUNCT
admet-286	280	1	these	these	DET
admet-286	280	2	breakpoints	breakpoint	NOUN
admet-286	280	3	were	be	AUX
admet-286	280	4	2	2	NUM
admet-286	280	5	fold	fold	NOUN
admet-286	280	6	higher	higher	ADV
admet-286	280	7	than	than	ADP
admet-286	280	8	vancomycin	vancomycin	PROPN
admet-286	280	9	alone	alone	ADJ
admet-286	280	10	treatments	treatment	NOUN
admet-286	280	11	.	.	PUNCT
admet-286	281	1	the	the	DET
admet-286	281	2	same	same	ADJ
admet-286	281	3	breakpoint	breakpoint	NOUN
admet-286	281	4	values	value	NOUN
admet-286	281	5	in	in	ADP
admet-286	281	6	in	in	ADP
admet-286	281	7	vitro	vitro	X
admet-286	281	8	(	(	PUNCT
admet-286	281	9	mic	mic	ADJ
admet-286	281	10	and	and	CCONJ
admet-286	281	11	ast	ast	NOUN
admet-286	281	12	breakpoint	breakpoint	NOUN
admet-286	281	13	estimation	estimation	NOUN
admet-286	281	14	)	)	PUNCT
admet-286	281	15	and	and	CCONJ
admet-286	281	16	simulated	simulate	VERB
admet-286	281	17	clinical	clinical	ADJ
admet-286	281	18	population	population	NOUN
admet-286	281	19	suggests	suggest	VERB
admet-286	281	20	that	that	SCONJ
admet-286	281	21	fdc	fdc	PROPN
admet-286	281	22	combination	combination	NOUN
admet-286	281	23	exhibits	exhibit	VERB
admet-286	281	24	same	same	ADJ
admet-286	281	25	pd	pd	NOUN
admet-286	281	26	effect	effect	NOUN
admet-286	281	27	in	in	ADP
admet-286	281	28	vitro	vitro	X
admet-286	281	29	that	that	SCONJ
admet-286	281	30	it	it	PRON
admet-286	281	31	should	should	AUX
admet-286	281	32	show	show	VERB
admet-286	281	33	in	in	ADP
admet-286	281	34	clinical	clinical	ADJ
admet-286	281	35	population	population	NOUN
admet-286	281	36	.	.	PUNCT
admet-286	282	1	thus	thus	ADV
admet-286	282	2	,	,	PUNCT
admet-286	282	3	the	the	DET
admet-286	282	4	study	study	NOUN
admet-286	282	5	corroborates	corroborate	VERB
admet-286	282	6	the	the	DET
admet-286	282	7	validity	validity	NOUN
admet-286	282	8	of	of	ADP
admet-286	282	9	antibacterial	antibacterial	ADJ
admet-286	282	10	effect	effect	NOUN
admet-286	282	11	of	of	ADP
admet-286	282	12	fdc	fdc	PROPN
admet-286	282	13	ceftriaxone	ceftriaxone	PROPN
admet-286	282	14	/	/	SYM
admet-286	282	15	vancomycin	vancomycin	PROPN
admet-286	282	16	(	(	PUNCT
admet-286	282	17	2/1	2/1	NUM
admet-286	282	18	w	w	PROPN
admet-286	282	19	/	/	SYM
admet-286	282	20	w/	w/	NOUN
admet-286	282	21	)	)	PUNCT
admet-286	282	22	in	in	ADP
admet-286	282	23	simulated	simulated	ADJ
admet-286	282	24	population	population	NOUN
admet-286	282	25	with	with	ADP
admet-286	282	26	unique	unique	ADJ
admet-286	282	27	advantage	advantage	NOUN
admet-286	282	28	of	of	ADP
admet-286	282	29	giving	give	VERB
admet-286	282	30	both	both	DET
admet-286	282	31	components	component	NOUN
admet-286	282	32	together	together	ADV
admet-286	282	33	in	in	ADP
admet-286	282	34	similar	similar	ADJ
admet-286	282	35	dosing	dose	VERB
admet-286	282	36	frequencies	frequency	NOUN
admet-286	282	37	.	.	PUNCT
admet-286	283	1	acknowledgements	acknowledgement	NOUN
admet-286	283	2	:	:	PUNCT
admet-286	283	3	this	this	DET
admet-286	283	4	research	research	NOUN
admet-286	283	5	was	be	AUX
admet-286	283	6	funded	fund	VERB
admet-286	283	7	by	by	ADP
admet-286	283	8	venus	venus	PROPN
admet-286	283	9	remedies	remedy	NOUN
admet-286	283	10	ltd	ltd	PROPN
admet-286	283	11	.	.	PROPN
admet-286	283	12	special	special	ADJ
admet-286	283	13	thanks	thank	NOUN
admet-286	283	14	are	be	AUX
admet-286	283	15	extended	extend	VERB
admet-286	283	16	to	to	ADP
admet-286	283	17	analytical	analytical	ADJ
admet-286	283	18	and	and	CCONJ
admet-286	283	19	microbiological	microbiological	ADJ
admet-286	283	20	department	department	NOUN
admet-286	283	21	of	of	ADP
admet-286	283	22	venus	venus	PROPN
admet-286	283	23	remedies	remedy	VERB
admet-286	283	24	for	for	ADP
admet-286	283	25	analyzing	analyze	VERB
admet-286	283	26	the	the	DET
admet-286	283	27	samples	sample	NOUN
admet-286	283	28	.	.	PUNCT
admet-286	284	1	references	reference	NOUN
admet-286	284	2	[	[	X
admet-286	284	3	1	1	NUM
admet-286	284	4	]	]	PUNCT
admet-286	284	5	e.	e.	PROPN
admet-286	284	6	klein	klein	PROPN
admet-286	284	7	,	,	PUNCT
admet-286	284	8	d.l	d.l	PROPN
admet-286	284	9	.	.	PROPN
admet-286	284	10	smith	smith	PROPN
admet-286	284	11	,	,	PUNCT
admet-286	284	12	r.	r.	PROPN
admet-286	284	13	laxminarayan	laxminarayan	PROPN
admet-286	284	14	,	,	PUNCT
admet-286	284	15	emerging	emerge	VERB
admet-286	284	16	infectious	infectious	ADJ
admet-286	284	17	disease	disease	NOUN
admet-286	284	18	13(12	13(12	NUM
admet-286	284	19	)	)	PUNCT
admet-286	284	20	(	(	PUNCT
admet-286	284	21	2007	2007	NUM
admet-286	284	22	)	)	PUNCT
admet-286	284	23	1840	1840	NUM
admet-286	284	24	-	-	SYM
admet-286	284	25	1846	1846	NUM
admet-286	284	26	.	.	PUNCT
admet-286	285	1	[	[	X
admet-286	285	2	2	2	NUM
admet-286	285	3	]	]	X
admet-286	285	4	f.c	f.c	PROPN
admet-286	285	5	.	.	PROPN
admet-286	285	6	tenover	tenover	PROPN
admet-286	285	7	,	,	PUNCT
admet-286	285	8	r.c	r.c	PROPN
admet-286	285	9	.	.	PROPN
admet-286	285	10	moellering	moellering	PROPN
admet-286	285	11	,	,	PUNCT
admet-286	285	12	clinical	clinical	ADJ
admet-286	285	13	infectious	infectious	ADJ
admet-286	285	14	diseases	disease	NOUN
admet-286	285	15	44(9	44(9	NUM
admet-286	285	16	)	)	PUNCT
admet-286	285	17	(	(	PUNCT
admet-286	285	18	2007	2007	NUM
admet-286	285	19	)	)	PUNCT
admet-286	285	20	1208	1208	NUM
admet-286	285	21	-	-	SYM
admet-286	285	22	1215	1215	NUM
admet-286	285	23	.	.	PUNCT
admet-286	286	1	[	[	X
admet-286	286	2	3	3	X
admet-286	286	3	]	]	X
admet-286	286	4	b.p	b.p	PROPN
admet-286	286	5	.	.	PUNCT
admet-286	286	6	howden	howden	PROPN
admet-286	286	7	,	,	PUNCT
admet-286	286	8	p.d	p.d	PROPN
admet-286	286	9	.	.	PROPN
admet-286	286	10	johnson	johnson	PROPN
admet-286	286	11	,	,	PUNCT
admet-286	286	12	p.b	p.b	PROPN
admet-286	286	13	.	.	PROPN
admet-286	286	14	ward	ward	PROPN
admet-286	286	15	,	,	PUNCT
admet-286	286	16	t.p	t.p	PROPN
admet-286	286	17	.	.	PROPN
admet-286	286	18	stinear	stinear	PROPN
admet-286	286	19	,	,	PUNCT
admet-286	286	20	j.k	j.k	PROPN
admet-286	286	21	.	.	PROPN
admet-286	286	22	davies	davy	NOUN
admet-286	286	23	,	,	PUNCT
admet-286	286	24	antimicrobial	antimicrobial	ADJ
admet-286	286	25	agents	agent	NOUN
admet-286	286	26	and	and	CCONJ
admet-286	286	27	chemotherapy	chemotherapy	NOUN
admet-286	286	28	50(9	50(9	NUM
admet-286	286	29	)	)	PUNCT
admet-286	286	30	(	(	PUNCT
admet-286	286	31	2006	2006	NUM
admet-286	286	32	)	)	PUNCT
admet-286	286	33	3039	3039	NUM
admet-286	286	34	-	-	SYM
admet-286	286	35	3047	3047	NUM
admet-286	286	36	.	.	PUNCT
admet-286	287	1	[	[	X
admet-286	287	2	4	4	NUM
admet-286	287	3	]	]	X
admet-286	287	4	p.g	p.g	PROPN
admet-286	287	5	.	.	PROPN
admet-286	287	6	charles	charles	PROPN
admet-286	287	7	,	,	PUNCT
admet-286	287	8	p.b	p.b	PROPN
admet-286	287	9	.	.	PROPN
admet-286	287	10	ward	ward	PROPN
admet-286	287	11	,	,	PUNCT
admet-286	287	12	p.d	p.d	PROPN
admet-286	287	13	.	.	PROPN
admet-286	287	14	johnson	johnson	PROPN
admet-286	287	15	,	,	PUNCT
admet-286	287	16	b.p	b.p	PROPN
admet-286	287	17	.	.	PUNCT
admet-286	287	18	howden	howden	PROPN
admet-286	287	19	,	,	PUNCT
admet-286	287	20	m.l	m.l	PROPN
admet-286	287	21	.	.	PROPN
admet-286	287	22	grayson	grayson	PROPN
admet-286	287	23	,	,	PUNCT
admet-286	287	24	clinical	clinical	ADJ
admet-286	287	25	infectious	infectious	ADJ
admet-286	287	26	diseases	disease	NOUN
admet-286	287	27	38(3	38(3	NUM
admet-286	287	28	)	)	PUNCT
admet-286	287	29	(	(	PUNCT
admet-286	287	30	2004	2004	NUM
admet-286	287	31	)	)	PUNCT
admet-286	287	32	448	448	NUM
admet-286	287	33	-	-	SYM
admet-286	287	34	451	451	NUM
admet-286	287	35	.	.	PUNCT
admet-286	288	1	[	[	X
admet-286	288	2	5	5	X
admet-286	288	3	]	]	X
admet-286	288	4	e.m	e.m	PROPN
admet-286	288	5	.	.	PROPN
admet-286	288	6	o'shaughnessy	o'shaughnessy	PROPN
admet-286	288	7	,	,	PUNCT
admet-286	288	8	j.	j.	PROPN
admet-286	288	9	meletiadis	meletiadis	PROPN
admet-286	288	10	,	,	PUNCT
admet-286	288	11	t.	t.	PROPN
admet-286	288	12	stergiopoulou	stergiopoulou	PROPN
admet-286	288	13	,	,	PUNCT
admet-286	288	14	j.p	j.p	PROPN
admet-286	288	15	.	.	PROPN
admet-286	288	16	demchok	demchok	PROPN
admet-286	288	17	,	,	PUNCT
admet-286	288	18	t.j	t.j	PROPN
admet-286	288	19	.	.	PROPN
admet-286	288	20	walsh	walsh	PROPN
admet-286	288	21	,	,	PUNCT
admet-286	288	22	journal	journal	NOUN
admet-286	288	23	of	of	ADP
admet-286	288	24	antimicrobial	antimicrobial	ADJ
admet-286	288	25	chemotherapy	chemotherapy	NOUN
admet-286	288	26	58(6	58(6	NOUN
admet-286	288	27	)	)	PUNCT
admet-286	288	28	(	(	PUNCT
admet-286	288	29	2006	2006	NUM
admet-286	288	30	)	)	PUNCT
admet-286	288	31	1168	1168	NUM
admet-286	288	32	-	-	SYM
admet-286	288	33	1176	1176	NUM
admet-286	288	34	.	.	PUNCT
admet-286	289	1	[	[	X
admet-286	289	2	6	6	NUM
admet-286	289	3	]	]	X
admet-286	289	4	e.i	e.i	PROPN
admet-286	289	5	.	.	PROPN
admet-286	289	6	nielsen	nielsen	PROPN
admet-286	289	7	,	,	PUNCT
admet-286	289	8	l.e	l.e	PROPN
admet-286	289	9	.	.	PROPN
admet-286	289	10	friberg	friberg	PROPN
admet-286	289	11	,	,	PUNCT
admet-286	289	12	pharmacological	pharmacological	ADJ
admet-286	289	13	reviews	review	NOUN
admet-286	289	14	65(3	65(3	NOUN
admet-286	289	15	)	)	PUNCT
admet-286	289	16	(	(	PUNCT
admet-286	289	17	2013	2013	NUM
admet-286	289	18	)	)	PUNCT
admet-286	289	19	1053	1053	NUM
admet-286	289	20	-	-	SYM
admet-286	289	21	1090	1090	NUM
admet-286	289	22	.	.	PUNCT
admet-286	290	1	[	[	X
admet-286	290	2	7	7	NUM
admet-286	290	3	]	]	X
admet-286	290	4	e.i	e.i	PROPN
admet-286	290	5	.	.	PROPN
admet-286	290	6	nielsen	nielsen	PROPN
admet-286	290	7	,	,	PUNCT
admet-286	290	8	a.	a.	PROPN
admet-286	290	9	viberg	viberg	PROPN
admet-286	290	10	,	,	PUNCT
admet-286	290	11	e.	e.	PROPN
admet-286	290	12	lowdin	lowdin	PROPN
admet-286	290	13	,	,	PUNCT
admet-286	290	14	o.	o.	PROPN
admet-286	290	15	cars	car	NOUN
admet-286	290	16	,	,	PUNCT
admet-286	290	17	m.o	m.o	PROPN
admet-286	290	18	.	.	PROPN
admet-286	290	19	karlsson	karlsson	PROPN
admet-286	290	20	,	,	PUNCT
admet-286	290	21	m.	m.	NOUN
admet-286	290	22	sandstrom	sandstrom	PROPN
admet-286	290	23	,	,	PUNCT
admet-286	290	24	antimicrobial	antimicrobial	ADJ
admet-286	290	25	agents	agent	NOUN
admet-286	290	26	and	and	CCONJ
admet-286	290	27	chemotherapy	chemotherapy	NOUN
admet-286	290	28	51(1	51(1	NUM
admet-286	290	29	)	)	PUNCT
admet-286	290	30	(	(	PUNCT
admet-286	290	31	2007)128	2007)128	PROPN
admet-286	290	32	-	-	PUNCT
admet-286	290	33	136	136	NUM
admet-286	290	34	.	.	PUNCT
admet-286	291	1	admet	admet	PROPN
admet-286	291	2	&	&	CCONJ
admet-286	291	3	dmpk	dmpk	PROPN
admet-286	291	4	4(3	4(3	NUM
admet-286	291	5	)	)	PUNCT
admet-286	291	6	(	(	PUNCT
admet-286	291	7	2016	2016	NUM
admet-286	291	8	)	)	PUNCT
admet-286	291	9	241	241	NUM
admet-286	291	10	-	-	SYM
admet-286	291	11	260	260	NUM
admet-286	291	12	dose	dose	NOUN
admet-286	291	13	optimization	optimization	NOUN
admet-286	291	14	of	of	ADP
admet-286	291	15	fdc	fdc	PROPN
admet-286	291	16	against	against	ADP
admet-286	291	17	s.	s.	PROPN
admet-286	291	18	aureus	aureus	PROPN
admet-286	291	19	resistant	resistant	ADJ
admet-286	291	20	bacteria	bacteria	NOUN
admet-286	291	21	doi	doi	NOUN
admet-286	291	22	:	:	PUNCT
admet-286	291	23	10.5599	10.5599	NUM
admet-286	291	24	/	/	SYM
admet-286	291	25	admet.4.3.286	admet.4.3.286	ADJ
admet-286	291	26	255	255	NUM
admet-286	291	27	[	[	X
admet-286	291	28	8	8	NUM
admet-286	291	29	]	]	X
admet-286	291	30	t.	t.	NOUN
admet-286	291	31	katsube	katsube	PROPN
admet-286	291	32	,	,	PUNCT
admet-286	291	33	y.	y.	PROPN
admet-286	291	34	yano	yano	PROPN
admet-286	291	35	,	,	PUNCT
admet-286	291	36	y.	y.	PROPN
admet-286	291	37	yamano	yamano	PROPN
admet-286	291	38	,	,	PUNCT
admet-286	291	39	t.	t.	PROPN
admet-286	291	40	munekage	munekage	PROPN
admet-286	291	41	,	,	PUNCT
admet-286	291	42	n.	n.	PROPN
admet-286	291	43	kuroda	kuroda	PROPN
admet-286	291	44	,	,	PUNCT
admet-286	291	45	m.	m.	PROPN
admet-286	291	46	takano	takano	PROPN
admet-286	291	47	,	,	PUNCT
admet-286	291	48	journal	journal	NOUN
admet-286	291	49	of	of	ADP
admet-286	291	50	pharmaceutical	pharmaceutical	PROPN
admet-286	291	51	sciences	science	NOUN
admet-286	291	52	97(9	97(9	NOUN
admet-286	291	53	)	)	PUNCT
admet-286	291	54	(	(	PUNCT
admet-286	291	55	2008	2008	NUM
admet-286	291	56	)	)	PUNCT
admet-286	291	57	4108	4108	NUM
admet-286	291	58	-	-	SYM
admet-286	291	59	4117	4117	NUM
admet-286	291	60	.	.	PUNCT
admet-286	292	1	[	[	X
admet-286	292	2	9	9	NUM
admet-286	292	3	]	]	X
admet-286	292	4	e.i	e.i	PROPN
admet-286	292	5	.	.	PROPN
admet-286	292	6	nielsen	nielsen	PROPN
admet-286	292	7	,	,	PUNCT
admet-286	292	8	o.	o.	PROPN
admet-286	292	9	cars	car	NOUN
admet-286	292	10	,	,	PUNCT
admet-286	292	11	l.e	l.e	PROPN
admet-286	292	12	.	.	PROPN
admet-286	292	13	friberg	friberg	PROPN
admet-286	292	14	,	,	PUNCT
admet-286	292	15	antimicrobial	antimicrobial	ADJ
admet-286	292	16	agents	agent	NOUN
admet-286	292	17	and	and	CCONJ
admet-286	292	18	chemotherapy	chemotherapy	NOUN
admet-286	292	19	55(10	55(10	NUM
admet-286	292	20	)	)	PUNCT
admet-286	292	21	(	(	PUNCT
admet-286	292	22	2011	2011	NUM
admet-286	292	23	)	)	PUNCT
admet-286	292	24	4619	4619	NUM
admet-286	292	25	-	-	SYM
admet-286	292	26	4630	4630	NUM
admet-286	292	27	.	.	PUNCT
admet-286	293	1	[	[	X
admet-286	293	2	10	10	NUM
admet-286	293	3	]	]	X
admet-286	293	4	b.d	b.d	PROPN
admet-286	293	5	.	.	PROPN
admet-286	293	6	vanscoy	vanscoy	PROPN
admet-286	293	7	,	,	PUNCT
admet-286	293	8	r.e	r.e	PROPN
admet-286	293	9	.	.	PROPN
admet-286	293	10	mendes	mendes	PROPN
admet-286	293	11	,	,	PUNCT
admet-286	293	12	m.	m.	NOUN
admet-286	293	13	castanheira	castanheira	PROPN
admet-286	293	14	,	,	PUNCT
admet-286	293	15	j.	j.	PROPN
admet-286	293	16	mccauley	mccauley	PROPN
admet-286	293	17	,	,	PUNCT
admet-286	293	18	s.m	s.m	PROPN
admet-286	293	19	.	.	PROPN
admet-286	293	20	bhavnani	bhavnani	PROPN
admet-286	293	21	,	,	PUNCT
admet-286	293	22	r.n	r.n	PROPN
admet-286	293	23	.	.	PROPN
admet-286	293	24	jones	jones	PROPN
admet-286	293	25	,	,	PUNCT
admet-286	293	26	l.v	l.v	PROPN
admet-286	293	27	.	.	PROPN
admet-286	293	28	friedrich	friedrich	PROPN
admet-286	293	29	,	,	PUNCT
admet-286	293	30	j.n	j.n	PROPN
admet-286	293	31	.	.	PROPN
admet-286	293	32	steenbergen	steenbergen	PROPN
admet-286	293	33	,	,	PUNCT
admet-286	293	34	p.g	p.g	PROPN
admet-286	293	35	.	.	PROPN
admet-286	293	36	ambrose	ambrose	PROPN
admet-286	293	37	,	,	PUNCT
admet-286	293	38	antimicrobial	antimicrobial	ADJ
admet-286	293	39	agents	agent	NOUN
admet-286	293	40	and	and	CCONJ
admet-286	293	41	chemotherapy	chemotherapy	NOUN
admet-286	293	42	58(10	58(10	NUM
admet-286	293	43	)	)	PUNCT
admet-286	293	44	(	(	PUNCT
admet-286	293	45	2014	2014	NUM
admet-286	293	46	)	)	PUNCT
admet-286	293	47	6024	6024	NUM
admet-286	293	48	-	-	SYM
admet-286	293	49	6031	6031	NUM
admet-286	293	50	.	.	PUNCT
admet-286	294	1	[	[	X
admet-286	294	2	11	11	NUM
admet-286	294	3	]	]	X
admet-286	294	4	v.d	v.d	PROPN
admet-286	294	5	.	.	PROPN
admet-286	294	6	sharma	sharma	PROPN
admet-286	294	7	,	,	PUNCT
admet-286	294	8	a.	a.	PROPN
admet-286	294	9	singla	singla	PROPN
admet-286	294	10	,	,	PUNCT
admet-286	294	11	m.	m.	PROPN
admet-286	294	12	chaudhary	chaudhary	PROPN
admet-286	294	13	,	,	PUNCT
admet-286	294	14	m.	m.	NOUN
admet-286	294	15	taneja	taneja	PROPN
admet-286	294	16	,	,	PUNCT
admet-286	294	17	international	international	ADJ
admet-286	294	18	journal	journal	NOUN
admet-286	294	19	of	of	ADP
admet-286	294	20	pharmaceutical	pharmaceutical	NOUN
admet-286	294	21	sciences	science	NOUN
admet-286	294	22	and	and	CCONJ
admet-286	294	23	research	research	NOUN
admet-286	294	24	7(4	7(4	NUM
admet-286	294	25	)	)	PUNCT
admet-286	294	26	(	(	PUNCT
admet-286	294	27	2016	2016	NUM
admet-286	294	28	)	)	PUNCT
admet-286	294	29	1503	1503	NUM
admet-286	294	30	-	-	SYM
admet-286	294	31	1512	1512	NUM
admet-286	294	32	.	.	PUNCT
admet-286	295	1	[	[	X
admet-286	295	2	12	12	NUM
admet-286	295	3	]	]	X
admet-286	295	4	s.a	s.a	PROPN
admet-286	295	5	.	.	PROPN
admet-286	295	6	van	van	PROPN
admet-286	295	7	wart	wart	PROPN
admet-286	295	8	,	,	PUNCT
admet-286	295	9	d.r	d.r	PROPN
admet-286	295	10	.	.	PROPN
admet-286	295	11	andes	andes	PROPN
admet-286	295	12	,	,	PUNCT
admet-286	295	13	p.g	p.g	PROPN
admet-286	295	14	.	.	PROPN
admet-286	295	15	ambrose	ambrose	PROPN
admet-286	295	16	,	,	PUNCT
admet-286	295	17	s.m	s.m	PROPN
admet-286	295	18	.	.	PROPN
admet-286	295	19	bhavnani	bhavnani	PROPN
admet-286	295	20	,	,	PUNCT
admet-286	295	21	diagnostic	diagnostic	ADJ
admet-286	295	22	microbiology	microbiology	NOUN
admet-286	295	23	and	and	CCONJ
admet-286	295	24	infectious	infectious	ADJ
admet-286	295	25	disease	disease	NOUN
admet-286	295	26	63(4	63(4	NOUN
admet-286	295	27	)	)	PUNCT
admet-286	295	28	(	(	PUNCT
admet-286	295	29	2009	2009	NUM
admet-286	295	30	)	)	PUNCT
admet-286	295	31	409	409	NUM
admet-286	295	32	-	-	SYM
admet-286	295	33	414	414	NUM
admet-286	295	34	.	.	PUNCT
admet-286	296	1	[	[	X
admet-286	296	2	13	13	NUM
admet-286	296	3	]	]	PUNCT
admet-286	296	4	a.	a.	NOUN
admet-286	296	5	ogden	ogden	PROPN
admet-286	296	6	,	,	PUNCT
admet-286	296	7	m.	m.	PROPN
admet-286	296	8	kuhn	kuhn	PROPN
admet-286	296	9	,	,	PUNCT
admet-286	296	10	m.	m.	NOUN
admet-286	296	11	dority	dority	NOUN
admet-286	296	12	,	,	PUNCT
admet-286	296	13	s.	s.	PROPN
admet-286	296	14	buist	buist	PROPN
admet-286	296	15	,	,	PUNCT
admet-286	296	16	s.	s.	PROPN
admet-286	296	17	mehrens	mehrens	PROPN
admet-286	296	18	,	,	PUNCT
admet-286	296	19	t.	t.	PROPN
admet-286	296	20	zhu	zhu	PROPN
admet-286	296	21	,	,	PUNCT
admet-286	296	22	d.	d.	PROPN
admet-286	296	23	xiao	xiao	PROPN
admet-286	296	24	,	,	PUNCT
admet-286	296	25	j.r	j.r	PROPN
admet-286	296	26	.	.	PROPN
admet-286	296	27	miller	miller	PROPN
admet-286	296	28	,	,	PUNCT
admet-286	296	29	d.	d.	PROPN
admet-286	296	30	hanna	hanna	PROPN
admet-286	296	31	,	,	PUNCT
admet-286	296	32	antimicrobial	antimicrobial	ADJ
admet-286	296	33	agents	agent	NOUN
admet-286	296	34	and	and	CCONJ
admet-286	296	35	chemotherapy	chemotherapy	NOUN
admet-286	296	36	56(1	56(1	NUM
admet-286	296	37	)	)	PUNCT
admet-286	296	38	(	(	PUNCT
admet-286	296	39	2012	2012	NUM
admet-286	296	40	)	)	PUNCT
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admet-286	296	42	-	-	SYM
admet-286	296	43	129	129	NUM
admet-286	296	44	.	.	PUNCT
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admet-286	297	2	14	14	NUM
admet-286	297	3	]	]	X
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admet-286	297	5	.	.	PUNCT
admet-286	297	6	leuthner	leuthner	PROPN
admet-286	297	7	,	,	PUNCT
admet-286	297	8	c.	c.	PROPN
admet-286	297	9	vidaillac	vidaillac	PROPN
admet-286	297	10	,	,	PUNCT
admet-286	297	11	c.m	c.m	PROPN
admet-286	297	12	.	.	PROPN
admet-286	297	13	cheung	cheung	PROPN
admet-286	297	14	,	,	PUNCT
admet-286	297	15	m.j	m.j	PROPN
admet-286	297	16	.	.	PROPN
admet-286	297	17	rybak	rybak	PROPN
admet-286	297	18	,	,	PUNCT
admet-286	297	19	antimicrobial	antimicrobial	ADJ
admet-286	297	20	agents	agent	NOUN
admet-286	297	21	and	and	CCONJ
admet-286	297	22	chemotherapy	chemotherapy	NOUN
admet-286	297	23	54(9	54(9	NOUN
admet-286	297	24	)	)	PUNCT
admet-286	297	25	(	(	PUNCT
admet-286	297	26	2010	2010	NUM
admet-286	297	27	)	)	PUNCT
admet-286	297	28	3799	3799	NUM
admet-286	297	29	-	-	SYM
admet-286	297	30	3803	3803	NUM
admet-286	297	31	.	.	PUNCT
admet-286	298	1	[	[	X
admet-286	298	2	15	15	NUM
admet-286	298	3	]	]	X
admet-286	298	4	v.d	v.d	PROPN
admet-286	298	5	.	.	PROPN
admet-286	298	6	sharma	sharma	PROPN
admet-286	298	7	,	,	PUNCT
admet-286	298	8	a.	a.	PROPN
admet-286	298	9	singla	singla	PROPN
admet-286	298	10	,	,	PUNCT
admet-286	298	11	m.	m.	PROPN
admet-286	298	12	chaudhary	chaudhary	PROPN
admet-286	298	13	,	,	PUNCT
admet-286	298	14	m.	m.	NOUN
admet-286	298	15	taneja	taneja	PROPN
admet-286	298	16	,	,	PUNCT
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admet-286	298	18	journal	journal	NOUN
admet-286	298	19	of	of	ADP
admet-286	298	20	pharmacy	pharmacy	NOUN
admet-286	298	21	and	and	CCONJ
admet-286	298	22	pharmaceutical	pharmaceutical	NOUN
admet-286	298	23	sciences	science	NOUN
admet-286	298	24	8(7	8(7	NUM
admet-286	298	25	)	)	PUNCT
admet-286	298	26	(	(	PUNCT
admet-286	298	27	2016	2016	NUM
admet-286	298	28	)	)	PUNCT
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admet-286	298	30	-	-	SYM
admet-286	298	31	353	353	NUM
admet-286	298	32	.	.	PUNCT
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admet-286	299	2	16	16	NUM
admet-286	299	3	]	]	X
admet-286	299	4	j.g	j.g	PROPN
admet-286	299	5	.	.	PROPN
admet-286	299	6	den	den	PROPN
admet-286	299	7	hollander	hollander	PROPN
admet-286	299	8	,	,	PUNCT
admet-286	299	9	j.w	j.w	PROPN
admet-286	299	10	.	.	PROPN
admet-286	299	11	mouton	mouton	PROPN
admet-286	299	12	,	,	PUNCT
admet-286	299	13	h.a	h.a	PROPN
admet-286	299	14	.	.	PROPN
admet-286	299	15	verbrugh	verbrugh	PROPN
admet-286	299	16	,	,	PUNCT
admet-286	299	17	antimicrobial	antimicrobial	ADJ
admet-286	299	18	agents	agent	NOUN
admet-286	299	19	and	and	CCONJ
admet-286	299	20	chemotherapy	chemotherapy	NOUN
admet-286	299	21	42(4	42(4	PROPN
admet-286	299	22	)	)	PUNCT
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admet-286	299	25	)	)	PUNCT
admet-286	299	26	744	744	NUM
admet-286	299	27	-	-	SYM
admet-286	299	28	748	748	NUM
admet-286	299	29	.	.	PUNCT
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admet-286	300	2	17	17	NUM
admet-286	300	3	]	]	X
admet-286	300	4	v.d	v.d	PROPN
admet-286	300	5	.	.	PROPN
admet-286	300	6	sharma	sharma	PROPN
admet-286	300	7	,	,	PUNCT
admet-286	300	8	a.	a.	PROPN
admet-286	300	9	singla	singla	PROPN
admet-286	300	10	,	,	PUNCT
admet-286	300	11	m.	m.	PROPN
admet-286	300	12	chaudhary	chaudhary	PROPN
admet-286	300	13	,	,	PUNCT
admet-286	300	14	m.	m.	NOUN
admet-286	300	15	taneja	taneja	PROPN
admet-286	300	16	,	,	PUNCT
admet-286	300	17	aaps	aap	NOUN
admet-286	300	18	pharmscitech	pharmscitech	VERB
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admet-286	300	20	)	)	PUNCT
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admet-286	300	22	2016	2016	NUM
admet-286	300	23	)	)	PUNCT
admet-286	300	24	1192	1192	NUM
admet-286	300	25	-	-	SYM
admet-286	300	26	1203	1203	NUM
admet-286	300	27	.	.	PUNCT
admet-286	301	1	[	[	X
admet-286	301	2	18	18	NUM
admet-286	301	3	]	]	SYM
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admet-286	301	5	.	.	PUNCT
admet-286	302	1	performance	performance	NOUN
admet-286	302	2	standards	standard	NOUN
admet-286	302	3	for	for	ADP
admet-286	302	4	antimicrobial	antimicrobial	ADJ
admet-286	302	5	disk	disk	NOUN
admet-286	302	6	susceptibility	susceptibility	NOUN
admet-286	302	7	tests	test	NOUN
admet-286	302	8	.	.	PUNCT
admet-286	303	1	clsi	clsi	VERB
admet-286	303	2	m02	m02	NOUN
admet-286	303	3	-	-	PUNCT
admet-286	303	4	a12	a12	NOUN
admet-286	303	5	(	(	PUNCT
admet-286	303	6	2015	2015	NUM
admet-286	303	7	)	)	PUNCT
admet-286	304	1	[	[	X
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admet-286	304	3	]	]	X
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admet-286	304	5	.	.	PROPN
admet-286	304	6	tariq	tariq	PROPN
admet-286	304	7	,	,	PUNCT
admet-286	304	8	j.	j.	PROPN
admet-286	304	9	kumar	kumar	PROPN
admet-286	304	10	,	,	PUNCT
admet-286	304	11	d.	d.	PROPN
admet-286	304	12	reddy	reddy	PROPN
admet-286	304	13	,	,	PUNCT
admet-286	304	14	m.	m.	PROPN
admet-286	304	15	chaudhary	chaudhary	PROPN
admet-286	304	16	,	,	PUNCT
admet-286	304	17	r.k	r.k	PROPN
admet-286	304	18	.	.	PROPN
admet-286	304	19	singh	singh	PROPN
admet-286	304	20	,	,	PUNCT
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admet-286	304	22	asia	asia	PROPN
admet-286	304	23	(	(	PUNCT
admet-286	304	24	36	36	NUM
admet-286	304	25	)	)	PUNCT
admet-286	304	26	(	(	PUNCT
admet-286	304	27	2010	2010	NUM
admet-286	304	28	)	)	PUNCT
admet-286	304	29	297	297	NUM
admet-286	304	30	-	-	SYM
admet-286	304	31	304	304	NUM
admet-286	304	32	.	.	PUNCT
admet-286	305	1	[	[	X
admet-286	305	2	20	20	NUM
admet-286	305	3	]	]	X
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admet-286	305	5	.	.	PROPN
admet-286	305	6	mcgrath	mcgrath	PROPN
admet-286	305	7	,	,	PUNCT
admet-286	305	8	k.c	k.c	PROPN
admet-286	305	9	.	.	PROPN
admet-286	305	10	lamp	lamp	PROPN
admet-286	305	11	,	,	PUNCT
admet-286	305	12	m.j	m.j	PROPN
admet-286	305	13	.	.	PROPN
admet-286	305	14	rybak	rybak	PROPN
admet-286	305	15	,	,	PUNCT
admet-286	305	16	antimicrobial	antimicrobial	ADJ
admet-286	305	17	agents	agent	NOUN
admet-286	305	18	and	and	CCONJ
admet-286	305	19	chemotherapy	chemotherapy	NOUN
admet-286	305	20	37	37	NUM
admet-286	305	21	(	(	PUNCT
admet-286	305	22	9	9	NUM
admet-286	305	23	)	)	PUNCT
admet-286	305	24	(	(	PUNCT
admet-286	305	25	1993	1993	NUM
admet-286	305	26	)	)	PUNCT
admet-286	305	27	19311937	19311937	NUM
admet-286	305	28	.	.	PUNCT
admet-286	306	1	[	[	X
admet-286	306	2	21	21	NUM
admet-286	306	3	]	]	X
admet-286	306	4	j.	j.	PROPN
admet-286	306	5	gloede	gloede	PROPN
admet-286	306	6	,	,	PUNCT
admet-286	306	7	c.	c.	PROPN
admet-286	306	8	scheerans	scheerans	PROPN
admet-286	306	9	,	,	PUNCT
admet-286	306	10	h.	h.	PROPN
admet-286	306	11	derendorf	derendorf	PROPN
admet-286	306	12	,	,	PUNCT
admet-286	306	13	c.	c.	PROPN
admet-286	306	14	kloft	kloft	PROPN
admet-286	306	15	,	,	PUNCT
admet-286	306	16	journal	journal	NOUN
admet-286	306	17	of	of	ADP
admet-286	306	18	antimicrobial	antimicrobial	ADJ
admet-286	306	19	chemotherapy	chemotherapy	NOUN
admet-286	306	20	65(2	65(2	NOUN
admet-286	306	21	)	)	PUNCT
admet-286	306	22	(	(	PUNCT
admet-286	306	23	2010	2010	NUM
admet-286	306	24	)	)	PUNCT
admet-286	306	25	186	186	NUM
admet-286	306	26	-	-	SYM
admet-286	306	27	201	201	NUM
admet-286	306	28	.	.	PUNCT
admet-286	307	1	[	[	X
admet-286	307	2	22	22	NUM
admet-286	307	3	]	]	X
admet-286	307	4	a.j	a.j	PROPN
admet-286	307	5	.	.	PROPN
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admet-286	307	7	,	,	PUNCT
admet-286	307	8	k.j	k.j	PROPN
admet-286	307	9	.	.	PROPN
admet-286	307	10	walker	walker	PROPN
admet-286	307	11	,	,	PUNCT
admet-286	307	12	j.k	j.k	PROPN
admet-286	307	13	.	.	PROPN
admet-286	307	14	raddatz	raddatz	PROPN
admet-286	307	15	,	,	PUNCT
admet-286	307	16	j.c	j.c	PROPN
admet-286	307	17	.	.	PROPN
admet-286	307	18	rotschafer	rotschafer	PROPN
admet-286	307	19	,	,	PUNCT
admet-286	307	20	journal	journal	NOUN
admet-286	307	21	of	of	ADP
admet-286	307	22	antimicrobial	antimicrobial	ADJ
admet-286	307	23	chemotherapy	chemotherapy	NOUN
admet-286	307	24	38(4	38(4	NUM
admet-286	307	25	)	)	PUNCT
admet-286	307	26	(	(	PUNCT
admet-286	307	27	1996	1996	NUM
admet-286	307	28	)	)	PUNCT
admet-286	307	29	589	589	NUM
admet-286	307	30	-	-	SYM
admet-286	307	31	597	597	NUM
admet-286	307	32	.	.	PUNCT
admet-286	308	1	[	[	X
admet-286	308	2	23	23	NUM
admet-286	308	3	]	]	X
admet-286	308	4	j.h	j.h	PROPN
admet-286	308	5	.	.	PROPN
admet-286	308	6	martin	martin	PROPN
admet-286	308	7	,	,	PUNCT
admet-286	308	8	r.	r.	PROPN
admet-286	308	9	norris	norris	PROPN
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admet-286	308	11	m.	m.	NOUN
admet-286	308	12	barras	barras	PROPN
admet-286	308	13	,	,	PUNCT
admet-286	308	14	j.	j.	PROPN
admet-286	308	15	roberts	roberts	PROPN
admet-286	308	16	,	,	PUNCT
admet-286	308	17	r.	r.	PROPN
admet-286	308	18	morris	morris	PROPN
admet-286	308	19	,	,	PUNCT
admet-286	308	20	m.	m.	NOUN
admet-286	308	21	doogue	doogue	PROPN
admet-286	308	22	,	,	PUNCT
admet-286	308	23	g.r	g.r	PROPN
admet-286	308	24	.	.	PROPN
admet-286	308	25	jones	jones	PROPN
admet-286	308	26	,	,	PUNCT
admet-286	308	27	clinical	clinical	ADJ
admet-286	308	28	biochemist	biochemist	NOUN
admet-286	308	29	reviews	review	VERB
admet-286	308	30	31(1	31(1	NUM
admet-286	308	31	)	)	PUNCT
admet-286	308	32	(	(	PUNCT
admet-286	308	33	2010	2010	NUM
admet-286	308	34	)	)	PUNCT
admet-286	308	35	21	21	NUM
admet-286	308	36	-	-	SYM
admet-286	308	37	24	24	NUM
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admet-286	308	39	24	24	NUM
admet-286	308	40	]	]	X
admet-286	308	41	i.h	i.h	PROPN
admet-286	308	42	.	.	PROPN
admet-286	308	43	patel	patel	PROPN
admet-286	308	44	,	,	PUNCT
admet-286	308	45	s.	s.	PROPN
admet-286	308	46	chen	chen	PROPN
admet-286	308	47	,	,	PUNCT
admet-286	308	48	m.	m.	NOUN
admet-286	308	49	parsonnet	parsonnet	PROPN
admet-286	308	50	,	,	PUNCT
admet-286	308	51	m.r	m.r	PROPN
admet-286	308	52	.	.	PROPN
admet-286	308	53	hackman	hackman	PROPN
admet-286	308	54	,	,	PUNCT
admet-286	308	55	m.a	m.a	PROPN
admet-286	308	56	.	.	PROPN
admet-286	308	57	brooks	brooks	PROPN
admet-286	308	58	,	,	PUNCT
admet-286	308	59	j.	j.	PROPN
admet-286	308	60	konikoff	konikoff	PROPN
admet-286	308	61	,	,	PUNCT
admet-286	308	62	s.a	s.a	PROPN
admet-286	308	63	.	.	PROPN
admet-286	308	64	kaplan	kaplan	PROPN
admet-286	308	65	,	,	PUNCT
admet-286	308	66	antimicrobial	antimicrobial	ADJ
admet-286	308	67	agents	agent	NOUN
admet-286	308	68	and	and	CCONJ
admet-286	308	69	chemotherapy	chemotherapy	NOUN
admet-286	308	70	20(5	20(5	NUM
admet-286	308	71	)	)	PUNCT
admet-286	308	72	(	(	PUNCT
admet-286	308	73	1981	1981	NUM
admet-286	308	74	)	)	PUNCT
admet-286	308	75	634	634	NUM
admet-286	308	76	-	-	SYM
admet-286	308	77	641	641	NUM
admet-286	308	78	.	.	PUNCT
admet-286	309	1	[	[	X
admet-286	309	2	25	25	NUM
admet-286	309	3	]	]	X
admet-286	309	4	w.j	w.j	PROPN
admet-286	309	5	.	.	PROPN
admet-286	309	6	jusko	jusko	PROPN
admet-286	309	7	,	,	PUNCT
admet-286	309	8	journal	journal	NOUN
admet-286	309	9	of	of	ADP
admet-286	309	10	pharmaceutical	pharmaceutical	PROPN
admet-286	309	11	sciences	science	NOUN
admet-286	309	12	60(6	60(6	NOUN
admet-286	309	13	)	)	PUNCT
admet-286	309	14	(	(	PUNCT
admet-286	309	15	1971	1971	NUM
admet-286	309	16	)	)	PUNCT
admet-286	309	17	892	892	NUM
admet-286	309	18	-	-	SYM
admet-286	309	19	895	895	NUM
admet-286	309	20	.	.	PUNCT
admet-286	310	1	[	[	X
admet-286	310	2	26	26	NUM
admet-286	310	3	]	]	X
admet-286	310	4	j.w	j.w	PROPN
admet-286	310	5	.	.	PROPN
admet-286	310	6	mouton	mouton	PROPN
admet-286	310	7	,	,	PUNCT
admet-286	310	8	a.a	a.a	PROPN
admet-286	310	9	.	.	PROPN
admet-286	310	10	vinks	vinks	PROPN
admet-286	310	11	,	,	PUNCT
admet-286	310	12	n.c	n.c	PROPN
admet-286	310	13	.	.	PROPN
admet-286	310	14	punt	punt	NOUN
admet-286	310	15	,	,	PUNCT
admet-286	310	16	antimicrobial	antimicrobial	ADJ
admet-286	310	17	agents	agent	NOUN
admet-286	310	18	and	and	CCONJ
admet-286	310	19	chemotherapy	chemotherapy	NOUN
admet-286	310	20	41(4	41(4	NUM
admet-286	310	21	)	)	PUNCT
admet-286	310	22	(	(	PUNCT
admet-286	310	23	1997	1997	NUM
admet-286	310	24	)	)	PUNCT
admet-286	310	25	733	733	NUM
admet-286	310	26	-	-	SYM
admet-286	310	27	738	738	NUM
admet-286	310	28	.	.	PUNCT
admet-286	311	1	[	[	X
admet-286	311	2	27	27	NUM
admet-286	311	3	]	]	X
admet-286	311	4	y.	y.	PROPN
admet-286	311	5	harigaya	harigaya	PROPN
admet-286	311	6	,	,	PUNCT
admet-286	311	7	j.b	j.b	PROPN
admet-286	311	8	.	.	PUNCT
admet-286	311	9	bulitta	bulitta	PROPN
admet-286	311	10	,	,	PUNCT
admet-286	311	11	a.	a.	NOUN
admet-286	311	12	forrest	forrest	PROPN
admet-286	311	13	,	,	PUNCT
admet-286	311	14	g.	g.	PROPN
admet-286	311	15	sakoulas	sakoulas	PROPN
admet-286	311	16	,	,	PUNCT
admet-286	311	17	a.j	a.j	PROPN
admet-286	311	18	.	.	PROPN
admet-286	311	19	lesse	lesse	PROPN
admet-286	311	20	,	,	PUNCT
admet-286	311	21	j.m	j.m	PROPN
admet-286	311	22	.	.	PROPN
admet-286	311	23	mylotte	mylotte	PROPN
admet-286	311	24	,	,	PUNCT
admet-286	311	25	b.t	b.t	PROPN
admet-286	311	26	.	.	PROPN
admet-286	311	27	tsuji	tsuji	PROPN
admet-286	311	28	,	,	PUNCT
admet-286	311	29	antimicrobial	antimicrobial	ADJ
admet-286	311	30	agents	agent	NOUN
admet-286	311	31	and	and	CCONJ
admet-286	311	32	chemotherapy	chemotherapy	NOUN
admet-286	311	33	53(9	53(9	NOUN
admet-286	311	34	)	)	PUNCT
admet-286	311	35	(	(	PUNCT
admet-286	311	36	2009	2009	NUM
admet-286	311	37	)	)	PUNCT
admet-286	311	38	3894	3894	NUM
admet-286	311	39	-	-	SYM
admet-286	311	40	3901	3901	NUM
admet-286	311	41	.	.	PUNCT
admet-286	312	1	[	[	X
admet-286	312	2	28	28	NUM
admet-286	312	3	]	]	X
admet-286	312	4	a.	a.	NOUN
admet-286	312	5	nolting	nolting	NOUN
admet-286	312	6	,	,	PUNCT
admet-286	312	7	t.	t.	PROPN
admet-286	312	8	dalla	dalla	PROPN
admet-286	312	9	costa	costa	PROPN
admet-286	312	10	,	,	PUNCT
admet-286	312	11	k.h	k.h	PROPN
admet-286	312	12	.	.	PROPN
admet-286	312	13	rand	rand	PROPN
admet-286	312	14	,	,	PUNCT
admet-286	312	15	h.	h.	PROPN
admet-286	312	16	derendorf	derendorf	PROPN
admet-286	312	17	,	,	PUNCT
admet-286	312	18	pharmaceutical	pharmaceutical	ADJ
admet-286	312	19	research	research	NOUN
admet-286	312	20	13(1	13(1	NUM
admet-286	312	21	)	)	PUNCT
admet-286	312	22	(	(	PUNCT
admet-286	312	23	1996	1996	NUM
admet-286	312	24	)	)	PUNCT
admet-286	312	25	91	91	NUM
admet-286	312	26	-	-	SYM
admet-286	312	27	96	96	NUM
admet-286	312	28	.	.	PUNCT
admet-286	313	1	[	[	X
admet-286	313	2	29	29	NUM
admet-286	313	3	]	]	X
admet-286	313	4	j.b	j.b	PROPN
admet-286	313	5	.	.	PUNCT
admet-286	313	6	bulitta	bulitta	PROPN
admet-286	313	7	,	,	PUNCT
admet-286	313	8	n.s	n.s	PROPN
admet-286	313	9	.	.	PROPN
admet-286	313	10	ly	ly	PROPN
admet-286	313	11	,	,	PUNCT
admet-286	313	12	j.c	j.c	PROPN
admet-286	313	13	.	.	PROPN
admet-286	313	14	yang	yang	PROPN
admet-286	313	15	,	,	PUNCT
admet-286	313	16	a.	a.	PROPN
admet-286	313	17	forrest	forrest	PROPN
admet-286	313	18	,	,	PUNCT
admet-286	313	19	w.j	w.j	PROPN
admet-286	313	20	.	.	PROPN
admet-286	313	21	jusko	jusko	PROPN
admet-286	313	22	,	,	PUNCT
admet-286	313	23	b.t	b.t	PROPN
admet-286	313	24	.	.	PROPN
admet-286	313	25	tsuji	tsuji	PROPN
admet-286	313	26	,	,	PUNCT
admet-286	313	27	antimicrobial	antimicrobial	ADJ
admet-286	313	28	agents	agent	NOUN
admet-286	313	29	and	and	CCONJ
admet-286	313	30	chemotherapy	chemotherapy	NOUN
admet-286	313	31	53(1	53(1	PROPN
admet-286	313	32	)	)	PUNCT
admet-286	313	33	(	(	PUNCT
admet-286	313	34	2009	2009	NUM
admet-286	313	35	)	)	PUNCT
admet-286	313	36	46	46	NUM
admet-286	313	37	-	-	SYM
admet-286	313	38	56	56	NUM
admet-286	313	39	.	.	PUNCT
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admet-286	314	2	30	30	NUM
admet-286	314	3	]	]	X
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admet-286	314	5	garot	garot	PROPN
admet-286	314	6	,	,	PUNCT
admet-286	314	7	r.	r.	PROPN
admet-286	314	8	respaud	respaud	PROPN
admet-286	314	9	,	,	PUNCT
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admet-286	314	12	,	,	PUNCT
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admet-286	314	18	,	,	PUNCT
admet-286	314	19	s.	s.	PROPN
admet-286	314	20	ehrmann	ehrmann	PROPN
admet-286	314	21	,	,	PUNCT
admet-286	314	22	d.	d.	PROPN
admet-286	314	23	perrotin	perrotin	PROPN
admet-286	314	24	,	,	PUNCT
admet-286	314	25	p.f	p.f	PROPN
admet-286	314	26	.	.	PROPN
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admet-286	314	28	,	,	PUNCT
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admet-286	314	30	le	le	PROPN
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admet-286	314	32	,	,	PUNCT
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admet-286	314	34	journal	journal	PROPN
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admet-286	314	36	clinical	clinical	ADJ
admet-286	314	37	pharmacology	pharmacology	NOUN
admet-286	314	38	72(5	72(5	NOUN
admet-286	314	39	)	)	PUNCT
admet-286	314	40	(	(	PUNCT
admet-286	314	41	2011	2011	NUM
admet-286	314	42	)	)	PUNCT
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admet-286	314	44	-	-	SYM
admet-286	314	45	767	767	NUM
admet-286	314	46	.	.	PUNCT
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admet-286	315	7	,	,	PUNCT
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admet-286	315	9	.	.	PROPN
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admet-286	315	11	,	,	PUNCT
admet-286	315	12	j.h	j.h	PROPN
admet-286	315	13	.	.	PROPN
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admet-286	315	15	,	,	PUNCT
admet-286	315	16	y.g	y.g	PROPN
admet-286	315	17	.	.	PROPN
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admet-286	315	19	,	,	PUNCT
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admet-286	315	26	)	)	PUNCT
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admet-286	315	29	)	)	PUNCT
admet-286	315	30	48	48	NUM
admet-286	315	31	-	-	SYM
admet-286	315	32	54	54	NUM
admet-286	315	33	.	.	PUNCT
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admet-286	316	5	.	.	PROPN
admet-286	316	6	tam	tam	PROPN
admet-286	316	7	,	,	PUNCT
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admet-286	316	9	nikolaou	nikolaou	PROPN
admet-286	316	10	,	,	PUNCT
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admet-286	316	15	)	)	PUNCT
admet-286	316	16	(	(	PUNCT
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admet-286	316	18	)	)	PUNCT
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admet-286	316	20	.	.	PUNCT
admet-286	317	1	[	[	X
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admet-286	317	5	.	.	PROPN
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admet-286	317	7	,	,	PUNCT
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admet-286	317	11	42	42	NUM
admet-286	317	12	(	(	PUNCT
admet-286	317	13	2006	2006	NUM
admet-286	317	14	)	)	PUNCT
admet-286	317	15	suppl	suppl	ADJ
admet-286	318	1	1	1	NUM
admet-286	318	2	:	:	PUNCT
admet-286	318	3	s35	s35	NOUN
admet-286	318	4	-	-	PUNCT
admet-286	318	5	39	39	NUM
admet-286	318	6	.	.	PUNCT
admet-286	319	1	[	[	X
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admet-286	319	3	]	]	X
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admet-286	319	5	.	.	PROPN
admet-286	319	6	baselt	baselt	PROPN
admet-286	319	7	,	,	PUNCT
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admet-286	319	14	in	in	ADP
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admet-286	321	3	)	)	PUNCT
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admet-286	321	5	publications	publication	NOUN
admet-286	321	6	,	,	PUNCT
admet-286	321	7	foster	foster	ADJ
admet-286	321	8	city	city	NOUN
admet-286	321	9	,	,	PUNCT
admet-286	321	10	ca	can	AUX
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admet-286	321	13	]	]	SYM
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admet-286	321	15	.	.	PROPN
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admet-286	321	17	,	,	PUNCT
admet-286	321	18	clinical	clinical	ADJ
admet-286	321	19	infectious	infectious	ADJ
admet-286	321	20	diseases	disease	NOUN
admet-286	321	21	27(1	27(1	NUM
admet-286	321	22	)	)	PUNCT
admet-286	321	23	(	(	PUNCT
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admet-286	321	25	)	)	PUNCT
admet-286	321	26	10	10	NUM
admet-286	321	27	-	-	SYM
admet-286	321	28	22	22	NUM
admet-286	322	1	[	[	X
admet-286	322	2	36	36	NUM
admet-286	322	3	]	]	X
admet-286	322	4	s.j	s.j	PROPN
admet-286	322	5	.	.	PROPN
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admet-286	322	7	,	,	PUNCT
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admet-286	322	9	.	.	PROPN
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admet-286	322	20	68(4	68(4	NUM
admet-286	322	21	)	)	PUNCT
admet-286	322	22	(	(	PUNCT
admet-286	322	23	2013	2013	NUM
admet-286	322	24	)	)	PUNCT
admet-286	323	1	743	743	NUM
admet-286	323	2	-	-	SYM
admet-286	323	3	748	748	NUM
admet-286	323	4	.	.	PUNCT
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admet-286	324	10	)	)	PUNCT
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admet-286	324	13	)	)	PUNCT
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admet-286	324	15	-	-	SYM
admet-286	324	16	260	260	NUM
admet-286	324	17	256	256	NUM
admet-286	324	18	[	[	SYM
admet-286	324	19	37	37	NUM
admet-286	324	20	]	]	X
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admet-286	324	22	.	.	PROPN
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admet-286	324	24	,	,	PUNCT
admet-286	324	25	g.g	g.g	PROPN
admet-286	324	26	.	.	PROPN
admet-286	324	27	zhanel	zhanel	PROPN
admet-286	324	28	,	,	PUNCT
admet-286	324	29	d.r	d.r	PROPN
admet-286	324	30	.	.	PROPN
admet-286	324	31	guay	guay	PROPN
admet-286	324	32	,	,	PUNCT
admet-286	324	33	clinical	clinical	ADJ
admet-286	324	34	pharmacokinetics	pharmacokinetic	NOUN
admet-286	324	35	11(4	11(4	NUM
admet-286	324	36	)	)	PUNCT
admet-286	324	37	(	(	PUNCT
admet-286	324	38	1986	1986	NUM
admet-286	324	39	)	)	PUNCT
admet-286	324	40	257	257	NUM
admet-286	324	41	-	-	SYM
admet-286	324	42	282	282	NUM
admet-286	324	43	.	.	PUNCT
admet-286	325	1	[	[	X
admet-286	325	2	38	38	NUM
admet-286	325	3	]	]	X
admet-286	325	4	v.d	v.d	PROPN
admet-286	325	5	.	.	PROPN
admet-286	325	6	sharma	sharma	PROPN
admet-286	325	7	,	,	PUNCT
admet-286	325	8	m.	m.	NOUN
admet-286	325	9	chaudhary	chaudhary	PROPN
admet-286	325	10	,	,	PUNCT
admet-286	325	11	m.	m.	NOUN
admet-286	325	12	taneja	taneja	PROPN
admet-286	325	13	,	,	PUNCT
admet-286	325	14	european	european	PROPN
admet-286	325	15	journal	journal	PROPN
admet-286	325	16	of	of	ADP
admet-286	325	17	pharmaceutical	pharmaceutical	NOUN
admet-286	325	18	and	and	CCONJ
admet-286	325	19	medical	medical	ADJ
admet-286	325	20	research	research	NOUN
admet-286	325	21	3(6	3(6	PROPN
admet-286	325	22	)	)	PUNCT
admet-286	325	23	(	(	PUNCT
admet-286	325	24	2016	2016	NUM
admet-286	325	25	)	)	PUNCT
admet-286	325	26	454	454	NUM
admet-286	325	27	-	-	SYM
admet-286	325	28	462	462	NUM
admet-286	325	29	.	.	PUNCT
admet-286	326	1	©	©	PROPN
admet-286	326	2	2016	2016	NUM
admet-286	326	3	by	by	ADP
admet-286	326	4	the	the	DET
admet-286	326	5	authors	author	NOUN
admet-286	326	6	;	;	PUNCT
admet-286	326	7	licensee	licensee	PROPN
admet-286	326	8	iapc	iapc	PROPN
admet-286	326	9	,	,	PUNCT
admet-286	326	10	zagreb	zagreb	PROPN
admet-286	326	11	,	,	PUNCT
admet-286	326	12	croatia	croatia	PROPN
admet-286	326	13	.	.	PUNCT
admet-286	327	1	this	this	DET
admet-286	327	2	article	article	NOUN
admet-286	327	3	is	be	AUX
admet-286	327	4	an	an	DET
admet-286	327	5	open	open	ADJ
admet-286	327	6	-	-	PUNCT
admet-286	327	7	access	access	NOUN
admet-286	327	8	article	article	NOUN
admet-286	327	9	distributed	distribute	VERB
admet-286	327	10	under	under	ADP
admet-286	327	11	the	the	DET
admet-286	327	12	terms	term	NOUN
admet-286	327	13	and	and	CCONJ
admet-286	327	14	conditions	condition	NOUN
admet-286	327	15	of	of	ADP
admet-286	327	16	the	the	DET
admet-286	327	17	creative	creative	ADJ
admet-286	327	18	commons	common	NOUN
admet-286	327	19	attribution	attribution	NOUN
admet-286	327	20	license	license	NOUN
admet-286	327	21	(	(	PUNCT
admet-286	327	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-286	327	23	)	)	PUNCT
admet-286	327	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-286	327	25	admet	admet	PROPN
admet-286	327	26	&	&	CCONJ
admet-286	327	27	dmpk	dmpk	PROPN
admet-286	327	28	4(3	4(3	NUM
admet-286	327	29	)	)	PUNCT
admet-286	327	30	(	(	PUNCT
admet-286	327	31	2016	2016	NUM
admet-286	327	32	)	)	PUNCT
admet-286	327	33	241	241	NUM
admet-286	327	34	-	-	SYM
admet-286	327	35	260	260	NUM
admet-286	327	36	dose	dose	NOUN
admet-286	327	37	optimization	optimization	NOUN
admet-286	327	38	of	of	ADP
admet-286	327	39	fdc	fdc	PROPN
admet-286	327	40	against	against	ADP
admet-286	327	41	s.	s.	PROPN
admet-286	327	42	aureus	aureus	PROPN
admet-286	327	43	resistant	resistant	ADJ
admet-286	327	44	bacteria	bacteria	NOUN
admet-286	327	45	doi	doi	NOUN
admet-286	327	46	:	:	PUNCT
admet-286	327	47	10.5599	10.5599	NUM
admet-286	327	48	/	/	SYM
admet-286	327	49	admet.4.3.286	admet.4.3.286	VERB
admet-286	327	50	257	257	NUM
admet-286	327	51	supplemental	supplemental	ADJ
admet-286	327	52	materials	material	NOUN
admet-286	327	53	supplement	supplement	NOUN
admet-286	327	54	table	table	NOUN
admet-286	327	55	1	1	NUM
admet-286	327	56	:	:	PUNCT
admet-286	327	57	bacterial	bacterial	ADJ
admet-286	327	58	density	density	NOUN
admet-286	327	59	reduction	reduction	NOUN
admet-286	327	60	at	at	ADP
admet-286	327	61	various	various	ADJ
admet-286	327	62	antibiotic	antibiotic	ADJ
admet-286	327	63	exposures	exposure	NOUN
admet-286	327	64	concentration	concentration	NOUN
admet-286	327	65	used	use	VERB
admet-286	327	66	(	(	PUNCT
admet-286	327	67	ceftriaxone	ceftriaxone	PROPN
admet-286	327	68	/	/	SYM
admet-286	327	69	vancomycin	vancomycin	PROPN
admet-286	327	70	µg	µg	PROPN
admet-286	327	71	/	/	SYM
admet-286	327	72	ml	ml	NOUN
admet-286	327	73	)	)	PUNCT
admet-286	327	74	folds	fold	NOUN
admet-286	327	75	of	of	ADP
admet-286	327	76	mic	mic	ADJ
admet-286	327	77	log	log	NOUN
admet-286	327	78	δcfu	δcfu	NOUN
admet-286	327	79	1.335/0.667	1.335/0.667	NOUN
admet-286	327	80	0.5	0.5	NUM
admet-286	327	81	-0.234	-0.234	SYM
admet-286	327	82	13.35/6.675	13.35/6.675	NUM
admet-286	327	83	5	5	NUM
admet-286	327	84	0.716	0.716	NUM
admet-286	327	85	26.7/13.35	26.7/13.35	NUM
admet-286	327	86	10	10	NUM
admet-286	327	87	0.977	0.977	NUM
admet-286	327	88	53.4/26.7	53.4/26.7	NUM
admet-286	327	89	20	20	NUM
admet-286	327	90	4.000	4.000	NUM
admet-286	327	91	133.5/66.75	133.5/66.75	NUM
admet-286	327	92	50	50	NUM
admet-286	327	93	4.058	4.058	NUM
admet-286	327	94	267.0/133.5	267.0/133.5	NUM
admet-286	327	95	100	100	NUM
admet-286	327	96	3.609	3.609	NUM
admet-286	327	97	534.0/267.0	534.0/267.0	NUM
admet-286	327	98	200	200	NUM
admet-286	327	99	4.719	4.719	NUM
admet-286	327	100	66.75/33.375	66.75/33.375	NOUN
admet-286	327	101	bd	bd	PROPN
admet-286	327	102	(	(	PUNCT
admet-286	327	103	total	total	ADJ
admet-286	327	104	exposure	exposure	NOUN
admet-286	327	105	:	:	PUNCT
admet-286	327	106	133.5/66.75	133.5/66.75	NUM
admet-286	327	107	)	)	PUNCT
admet-286	327	108	50	50	NUM
admet-286	327	109	5.55	5.55	NUM
admet-286	327	110	44.5/22.25	44.5/22.25	NUM
admet-286	327	111	tid	tid	NOUN
admet-286	327	112	(	(	PUNCT
admet-286	327	113	total	total	ADJ
admet-286	327	114	exposure	exposure	NOUN
admet-286	327	115	:	:	PUNCT
admet-286	327	116	133.5/66.75	133.5/66.75	NUM
admet-286	327	117	)	)	PUNCT
admet-286	327	118	50	50	NUM
admet-286	327	119	2.32	2.32	NUM
admet-286	327	120	the	the	DET
admet-286	327	121	concentrations	concentration	NOUN
admet-286	327	122	of	of	ADP
admet-286	327	123	individual	individual	ADJ
admet-286	327	124	component	component	NOUN
admet-286	327	125	of	of	ADP
admet-286	327	126	fdc	fdc	PROPN
admet-286	327	127	and	and	CCONJ
admet-286	327	128	bacterial	bacterial	ADJ
admet-286	327	129	cfu	cfu	NOUN
admet-286	327	130	-	-	PUNCT
admet-286	327	131	time	time	NOUN
admet-286	327	132	profiles	profile	NOUN
admet-286	327	133	were	be	AUX
admet-286	327	134	obtained	obtain	VERB
admet-286	327	135	from	from	ADP
admet-286	327	136	in	in	ADP
admet-286	327	137	vitro	vitro	X
admet-286	327	138	chemostat	chemostat	PROPN
admet-286	327	139	model	model	PROPN
admet-286	327	140	.	.	PUNCT
admet-286	328	1	bacterial	bacterial	ADJ
admet-286	328	2	killing	killing	NOUN
admet-286	328	3	increase	increase	NOUN
admet-286	328	4	with	with	ADP
admet-286	328	5	increase	increase	NOUN
admet-286	328	6	in	in	ADP
admet-286	328	7	drug	drug	NOUN
admet-286	328	8	exposure	exposure	NOUN
admet-286	328	9	till	till	SCONJ
admet-286	328	10	the	the	DET
admet-286	328	11	saturation	saturation	NOUN
admet-286	328	12	is	be	AUX
admet-286	328	13	achieved	achieve	VERB
admet-286	328	14	i.e.	i.e.	X
admet-286	328	15	from	from	ADP
admet-286	328	16	0.5	0.5	NUM
admet-286	328	17	-50	-50	PUNCT
admet-286	328	18	folds	fold	NOUN
admet-286	328	19	of	of	ADP
admet-286	328	20	mic	mic	ADJ
admet-286	328	21	and	and	CCONJ
admet-286	328	22	after	after	ADP
admet-286	328	23	saturation	saturation	NOUN
admet-286	328	24	,	,	PUNCT
admet-286	328	25	further	further	ADJ
admet-286	328	26	increase	increase	NOUN
admet-286	328	27	in	in	ADP
admet-286	328	28	drug	drug	NOUN
admet-286	328	29	concentration	concentration	NOUN
admet-286	328	30	from	from	ADP
admet-286	328	31	50	50	NUM
admet-286	328	32	to	to	ADP
admet-286	328	33	200	200	NUM
admet-286	328	34	folds	fold	NOUN
admet-286	328	35	of	of	ADP
admet-286	328	36	mic	mic	NOUN
admet-286	328	37	,	,	PUNCT
admet-286	328	38	there	there	PRON
admet-286	328	39	was	be	VERB
admet-286	328	40	no	no	DET
admet-286	328	41	substantial	substantial	ADJ
admet-286	328	42	increase	increase	NOUN
admet-286	328	43	in	in	ADP
admet-286	328	44	anti	anti	ADJ
admet-286	328	45	-	-	ADJ
admet-286	328	46	bacterial	bacterial	ADJ
admet-286	328	47	effect	effect	NOUN
admet-286	328	48	of	of	ADP
admet-286	328	49	antibiotic	antibiotic	ADJ
admet-286	328	50	combination	combination	NOUN
admet-286	328	51	.	.	PUNCT
admet-286	329	1	further	far	ADV
admet-286	329	2	,	,	PUNCT
admet-286	329	3	selected	select	VERB
admet-286	329	4	total	total	ADJ
admet-286	329	5	exposure	exposure	NOUN
admet-286	329	6	(	(	PUNCT
admet-286	329	7	133.5/66.75	133.5/66.75	NOUN
admet-286	329	8	µg	µg	NOUN
admet-286	329	9	/	/	SYM
admet-286	329	10	ml	ml	NOUN
admet-286	329	11	)	)	PUNCT
admet-286	329	12	of	of	ADP
admet-286	329	13	50	50	NUM
admet-286	329	14	fold	fold	ADJ
admet-286	329	15	mic	mic	NOUN
admet-286	329	16	was	be	AUX
admet-286	329	17	fractionated	fractionate	VERB
admet-286	329	18	into	into	ADP
admet-286	329	19	twice	twice	ADV
admet-286	329	20	daily	daily	ADJ
admet-286	329	21	and	and	CCONJ
admet-286	329	22	thrice	thrice	NOUN
admet-286	329	23	daily	daily	ADJ
admet-286	329	24	regimens	regimen	NOUN
admet-286	329	25	.	.	PUNCT
admet-286	330	1	the	the	DET
admet-286	330	2	twice	twice	ADJ
admet-286	330	3	daily	daily	ADJ
admet-286	330	4	regimen	regiman	NOUN
admet-286	330	5	showed	show	VERB
admet-286	330	6	enhanced	enhance	VERB
admet-286	330	7	bacterial	bacterial	ADJ
admet-286	330	8	killing	killing	NOUN
admet-286	330	9	.	.	PUNCT
admet-286	331	1	cfu	cfu	NOUN
admet-286	331	2	colony	colony	NOUN
admet-286	331	3	forming	form	VERB
admet-286	331	4	units	unit	NOUN
admet-286	332	1	;	;	PUNCT
admet-286	332	2	fdc	fdc	PROPN
admet-286	332	3	fixed	fix	VERB
admet-286	332	4	dose	dose	NOUN
admet-286	332	5	combination	combination	NOUN
admet-286	332	6	;	;	PUNCT
admet-286	332	7	mic	mic	ADJ
admet-286	332	8	minimum	minimum	ADJ
admet-286	332	9	inhibitory	inhibitory	ADJ
admet-286	332	10	concentration	concentration	NOUN
admet-286	332	11	supplement	supplement	NOUN
admet-286	332	12	table	table	NOUN
admet-286	332	13	2	2	NUM
admet-286	332	14	:	:	PUNCT
admet-286	332	15	clinical	clinical	ADJ
admet-286	332	16	,	,	PUNCT
admet-286	332	17	mic	mic	ADJ
admet-286	332	18	and	and	CCONJ
admet-286	332	19	ast	ast	NOUN
admet-286	332	20	breakpoints	breakpoint	NOUN
admet-286	332	21	of	of	ADP
admet-286	332	22	150	150	NUM
admet-286	332	23	bacterial	bacterial	ADJ
admet-286	332	24	isolates	isolate	NOUN
admet-286	332	25	of	of	ADP
admet-286	332	26	mrsa	mrsa	NOUN
admet-286	332	27	breakpoints	breakpoint	NOUN
admet-286	332	28	susceptible	susceptible	ADJ
admet-286	332	29	intermediate	intermediate	ADJ
admet-286	332	30	resistant	resistant	ADJ
admet-286	332	31	clinical	clinical	ADJ
admet-286	332	32	(	(	PUNCT
admet-286	332	33	µg	µg	ADJ
admet-286	332	34	/	/	SYM
admet-286	332	35	ml	ml	NOUN
admet-286	332	36	)	)	PUNCT
admet-286	332	37	≤4	≤4	ADJ
admet-286	332	38	8	8	NUM
admet-286	332	39	-	-	SYM
admet-286	332	40	16	16	NUM
admet-286	332	41	≥32	≥32	PROPN
admet-286	332	42	mic	mic	ADJ
admet-286	332	43	(	(	PUNCT
admet-286	332	44	µg	µg	ADJ
admet-286	332	45	/	/	SYM
admet-286	332	46	ml	ml	NOUN
admet-286	332	47	)	)	PUNCT
admet-286	332	48	≤4	≤4	ADJ
admet-286	332	49	8	8	NUM
admet-286	332	50	-	-	SYM
admet-286	332	51	16	16	NUM
admet-286	332	52	≥32	≥32	PROPN
admet-286	332	53	ast	ast	NOUN
admet-286	332	54	(	(	PUNCT
admet-286	332	55	mm	mm	NOUN
admet-286	332	56	)	)	PUNCT
admet-286	332	57	<	<	X
admet-286	332	58	14	14	NUM
admet-286	332	59	14	14	NUM
admet-286	332	60	-	-	SYM
admet-286	332	61	17	17	NUM
admet-286	332	62	>	>	SYM
admet-286	332	63	17	17	NUM
admet-286	332	64	the	the	DET
admet-286	332	65	in	in	ADV
admet-286	332	66	vitro	vitro	X
admet-286	332	67	antibacterial	antibacterial	ADJ
admet-286	332	68	activity	activity	NOUN
admet-286	332	69	of	of	ADP
admet-286	332	70	fdc	fdc	PROPN
admet-286	332	71	was	be	AUX
admet-286	332	72	evaluated	evaluate	VERB
admet-286	332	73	against	against	ADP
admet-286	332	74	mrsa	mrsa	NOUN
admet-286	332	75	.	.	PUNCT
admet-286	333	1	the	the	DET
admet-286	333	2	clinical	clinical	ADJ
admet-286	333	3	breakpoint	breakpoint	NOUN
admet-286	333	4	was	be	AUX
admet-286	333	5	estimated	estimate	VERB
admet-286	333	6	from	from	ADP
admet-286	333	7	monte	monte	PROPN
admet-286	333	8	carlo	carlo	PROPN
admet-286	333	9	simulations	simulation	NOUN
admet-286	333	10	.	.	PUNCT
admet-286	334	1	the	the	DET
admet-286	334	2	mic	mic	ADJ
admet-286	334	3	breakpoints	breakpoint	NOUN
admet-286	334	4	were	be	AUX
admet-286	334	5	determined	determine	VERB
admet-286	334	6	based	base	VERB
admet-286	334	7	on	on	ADP
admet-286	334	8	target	target	NOUN
admet-286	334	9	attainment	attainment	NOUN
admet-286	334	10	of	of	ADP
admet-286	334	11	pk	pk	PROPN
admet-286	334	12	/	/	SYM
admet-286	334	13	pd	pd	NOUN
admet-286	334	14	index	index	NOUN
admet-286	334	15	%	%	PROPN
admet-286	334	16	t	t	PROPN
admet-286	334	17	>	>	X
admet-286	334	18	mic	mic	ADJ
admet-286	334	19	(	(	PUNCT
admet-286	334	20	≈50	≈50	NUM
admet-286	334	21	%	%	NOUN
admet-286	334	22	t	t	X
admet-286	334	23	>	>	X
admet-286	334	24	mic	mic	NOUN
admet-286	334	25	)	)	PUNCT
admet-286	334	26	.	.	PUNCT
admet-286	335	1	the	the	DET
admet-286	335	2	ast	ast	NOUN
admet-286	335	3	breakpoints	breakpoint	NOUN
admet-286	335	4	were	be	AUX
admet-286	335	5	determined	determine	VERB
admet-286	335	6	using	use	VERB
admet-286	335	7	least	least	ADJ
admet-286	335	8	square	square	ADJ
admet-286	335	9	regression	regression	NOUN
admet-286	335	10	analysis	analysis	NOUN
admet-286	335	11	of	of	ADP
admet-286	335	12	zone	zone	NOUN
admet-286	335	13	diameter	diameter	NOUN
admet-286	335	14	values	value	NOUN
admet-286	335	15	with	with	ADP
admet-286	335	16	the	the	DET
admet-286	335	17	corresponding	corresponding	ADJ
admet-286	335	18	mic	mic	ADJ
admet-286	335	19	values	value	NOUN
admet-286	335	20	of	of	ADP
admet-286	335	21	the	the	DET
admet-286	335	22	fdc	fdc	PROPN
admet-286	335	23	combination	combination	NOUN
admet-286	335	24	against	against	ADP
admet-286	335	25	150	150	NUM
admet-286	335	26	bacterial	bacterial	ADJ
admet-286	335	27	isolates	isolate	NOUN
admet-286	335	28	of	of	ADP
admet-286	335	29	mrsa	mrsa	NOUN
admet-286	335	30	.	.	PUNCT
admet-286	336	1	ast	ast	PROPN
admet-286	336	2	antimicrobial	antimicrobial	ADJ
admet-286	336	3	susceptibility	susceptibility	NOUN
admet-286	336	4	test	test	NOUN
admet-286	336	5	;	;	PUNCT
admet-286	336	6	cfu	cfu	NOUN
admet-286	336	7	colony	colony	NOUN
admet-286	336	8	forming	form	VERB
admet-286	336	9	units	unit	NOUN
admet-286	336	10	;	;	PUNCT
admet-286	336	11	fdc	fdc	PROPN
admet-286	336	12	fixed	fix	VERB
admet-286	336	13	dose	dose	NOUN
admet-286	336	14	combination	combination	NOUN
admet-286	336	15	;	;	PUNCT
admet-286	336	16	mic	mic	ADJ
admet-286	336	17	minimum	minimum	ADJ
admet-286	336	18	inhibitory	inhibitory	ADJ
admet-286	336	19	concentration	concentration	NOUN
admet-286	336	20	;	;	PUNCT
admet-286	336	21	mrsa	mrsa	NOUN
admet-286	336	22	methicillin	methicillin	NOUN
admet-286	336	23	resistant	resistant	ADJ
admet-286	336	24	staphylococcus	staphylococcus	NOUN
admet-286	336	25	aureus	aureus	NOUN
admet-286	336	26	;	;	PUNCT
admet-286	336	27	pk	pk	NOUN
admet-286	336	28	/	/	SYM
admet-286	336	29	pd	pd	NOUN
admet-286	336	30	pharmacokinetic	pharmacokinetic	NOUN
admet-286	336	31	/	/	SYM
admet-286	336	32	pharmacodynamic	pharmacodynamic	ADJ
admet-286	336	33	;	;	PUNCT
admet-286	336	34	%	%	NOUN
admet-286	336	35	t	t	X
admet-286	336	36	>	>	X
admet-286	336	37	mic	mic	ADJ
admet-286	336	38	%	%	NOUN
admet-286	336	39	time	time	NOUN
admet-286	336	40	for	for	ADP
admet-286	336	41	which	which	PRON
admet-286	336	42	the	the	DET
admet-286	336	43	levels	level	NOUN
admet-286	336	44	of	of	ADP
admet-286	336	45	antibiotic	antibiotic	NOUN
admet-286	336	46	in	in	ADP
admet-286	336	47	serum	serum	NOUN
admet-286	336	48	/	/	SYM
admet-286	336	49	plasma	plasma	NOUN
admet-286	336	50	exceed	exceed	VERB
admet-286	336	51	the	the	DET
admet-286	336	52	mic	mic	NOUN
admet-286	336	53	.	.	PUNCT
admet-286	337	1	vishnu	vishnu	PROPN
admet-286	337	2	sharma	sharma	PROPN
admet-286	337	3	et	et	PROPN
admet-286	337	4	al	al	PROPN
admet-286	337	5	.	.	PROPN
admet-286	337	6	admet	admet	PROPN
admet-286	337	7	&	&	CCONJ
admet-286	337	8	dmpk	dmpk	PROPN
admet-286	337	9	4(3	4(3	NUM
admet-286	337	10	)	)	PUNCT
admet-286	337	11	(	(	PUNCT
admet-286	337	12	2016	2016	NUM
admet-286	337	13	)	)	PUNCT
admet-286	337	14	241	241	NUM
admet-286	337	15	-	-	SYM
admet-286	337	16	260	260	NUM
admet-286	337	17	258	258	NUM
admet-286	337	18	supplement	supplement	NOUN
admet-286	337	19	figure	figure	NOUN
admet-286	337	20	1	1	NUM
admet-286	337	21	:	:	PUNCT
admet-286	337	22	pharmacokinetic	pharmacokinetic	ADJ
admet-286	337	23	/	/	SYM
admet-286	337	24	pharmacodynamic	pharmacodynamic	ADJ
admet-286	337	25	indices	index	NOUN
admet-286	337	26	of	of	ADP
admet-286	337	27	individual	individual	ADJ
admet-286	337	28	components	component	NOUN
admet-286	337	29	of	of	ADP
admet-286	337	30	fdc	fdc	PROPN
admet-286	337	31	and	and	CCONJ
admet-286	337	32	their	their	PRON
admet-286	337	33	relationship	relationship	NOUN
admet-286	337	34	with	with	ADP
admet-286	337	35	log	log	NOUN
admet-286	337	36	fold	fold	NOUN
admet-286	337	37	change	change	NOUN
admet-286	337	38	in	in	ADP
admet-286	337	39	bacterial	bacterial	ADJ
admet-286	337	40	density	density	NOUN
admet-286	337	41	the	the	DET
admet-286	337	42	pk	pk	NOUN
admet-286	337	43	/	/	SYM
admet-286	337	44	pd	pd	PROPN
admet-286	337	45	indices	index	NOUN
admet-286	337	46	i.e.	i.e.	X
admet-286	337	47	auc	auc	NOUN
admet-286	337	48	/	/	SYM
admet-286	337	49	mic	mic	ADJ
admet-286	337	50	,	,	PUNCT
admet-286	337	51	cmax	cmax	NOUN
admet-286	337	52	/	/	SYM
admet-286	337	53	mic	mic	ADJ
admet-286	337	54	and	and	CCONJ
admet-286	337	55	%	%	NOUN
admet-286	337	56	t	t	PROPN
admet-286	337	57	>	>	X
admet-286	337	58	mic	mic	NOUN
admet-286	337	59	were	be	AUX
admet-286	337	60	calculated	calculate	VERB
admet-286	337	61	for	for	ADP
admet-286	337	62	both	both	CCONJ
admet-286	337	63	ceftriaxone	ceftriaxone	NOUN
admet-286	337	64	and	and	CCONJ
admet-286	337	65	vancomycin	vancomycin	PROPN
admet-286	337	66	using	use	VERB
admet-286	337	67	their	their	PRON
admet-286	337	68	respective	respective	ADJ
admet-286	337	69	pk	pk	NOUN
admet-286	337	70	parameters	parameter	NOUN
admet-286	337	71	.	.	PUNCT
admet-286	338	1	the	the	DET
admet-286	338	2	log	log	NOUN
admet-286	338	3	transformations	transformation	NOUN
admet-286	338	4	were	be	AUX
admet-286	338	5	done	do	VERB
admet-286	338	6	for	for	ADP
admet-286	338	7	auc	auc	NOUN
admet-286	338	8	/	/	SYM
admet-286	338	9	mic	mic	ADJ
admet-286	338	10	and	and	CCONJ
admet-286	338	11	cmax	cmax	NOUN
admet-286	338	12	/	/	SYM
admet-286	338	13	mic	mic	NOUN
admet-286	338	14	.	.	PUNCT
admet-286	339	1	the	the	DET
admet-286	339	2	log	log	NOUN
admet-286	339	3	transformed	transform	VERB
admet-286	339	4	pk	pk	PROPN
admet-286	339	5	/	/	SYM
admet-286	339	6	pd	pd	PROPN
admet-286	339	7	indices	index	NOUN
admet-286	339	8	and	and	CCONJ
admet-286	339	9	%	%	INTJ
admet-286	339	10	t	t	PROPN
admet-286	339	11	>	>	X
admet-286	339	12	mic	mic	NOUN
admet-286	339	13	were	be	AUX
admet-286	339	14	plotted	plot	VERB
admet-286	339	15	against	against	ADP
admet-286	339	16	log	log	NOUN
admet-286	339	17	fold	fold	NOUN
admet-286	339	18	change	change	NOUN
admet-286	339	19	in	in	ADP
admet-286	339	20	bacterial	bacterial	ADJ
admet-286	339	21	density	density	NOUN
admet-286	339	22	.	.	PUNCT
admet-286	340	1	the	the	DET
admet-286	340	2	data	datum	NOUN
admet-286	340	3	was	be	AUX
admet-286	340	4	fitted	fit	VERB
admet-286	340	5	with	with	ADP
admet-286	340	6	a	a	DET
admet-286	340	7	sigmoidal	sigmoidal	NOUN
admet-286	340	8	emax	emax	NOUN
admet-286	340	9	type	type	NOUN
admet-286	340	10	function	function	NOUN
admet-286	340	11	.	.	PUNCT
admet-286	341	1	the	the	DET
admet-286	341	2	selection	selection	NOUN
admet-286	341	3	of	of	ADP
admet-286	341	4	pk	pk	PROPN
admet-286	341	5	/	/	SYM
admet-286	341	6	pd	pd	PROPN
admet-286	341	7	driver	driver	NOUN
admet-286	341	8	was	be	AUX
admet-286	341	9	based	base	VERB
admet-286	341	10	on	on	ADP
admet-286	341	11	coefficient	coefficient	NOUN
admet-286	341	12	of	of	ADP
admet-286	341	13	correlation	correlation	NOUN
admet-286	341	14	(	(	PUNCT
admet-286	341	15	r2	r2	PROPN
admet-286	341	16	)	)	PUNCT
admet-286	341	17	,	,	PUNCT
admet-286	341	18	and	and	CCONJ
admet-286	341	19	sigmoidal	sigmoidal	NOUN
admet-286	341	20	factor	factor	NOUN
admet-286	341	21	(	(	PUNCT
admet-286	341	22	γ	γ	NOUN
admet-286	341	23	:	:	PUNCT
admet-286	341	24	hill	hill	NOUN
admet-286	341	25	factor	factor	NOUN
admet-286	341	26	)	)	PUNCT
admet-286	341	27	values	value	NOUN
admet-286	341	28	.	.	PUNCT
admet-286	342	1	a.	a.	NOUN
admet-286	342	2	model	model	PROPN
admet-286	342	3	fitted	fit	VERB
admet-286	342	4	values	value	NOUN
admet-286	342	5	of	of	ADP
admet-286	342	6	ceftriaxone	ceftriaxone	PROPN
admet-286	342	7	pk	pk	PROPN
admet-286	342	8	/	/	SYM
admet-286	342	9	pd	pd	PROPN
admet-286	342	10	indices	index	NOUN
admet-286	342	11	and	and	CCONJ
admet-286	342	12	its	its	PRON
admet-286	342	13	relationship	relationship	NOUN
admet-286	342	14	with	with	ADP
admet-286	342	15	log	log	NOUN
admet-286	342	16	fold	fold	NOUN
admet-286	342	17	change	change	NOUN
admet-286	342	18	in	in	ADP
admet-286	342	19	bacterial	bacterial	ADJ
admet-286	342	20	density	density	NOUN
admet-286	342	21	;	;	PUNCT
admet-286	342	22	b.	b.	PROPN
admet-286	342	23	model	model	PROPN
admet-286	342	24	fitted	fit	VERB
admet-286	342	25	values	value	NOUN
admet-286	342	26	of	of	ADP
admet-286	342	27	vancomycin	vancomycin	PROPN
admet-286	342	28	pk	pk	PROPN
admet-286	342	29	/	/	SYM
admet-286	342	30	pd	pd	PROPN
admet-286	342	31	indices	index	NOUN
admet-286	342	32	and	and	CCONJ
admet-286	342	33	its	its	PRON
admet-286	342	34	relationship	relationship	NOUN
admet-286	342	35	with	with	ADP
admet-286	342	36	log	log	NOUN
admet-286	342	37	fold	fold	NOUN
admet-286	342	38	change	change	NOUN
admet-286	342	39	in	in	ADP
admet-286	342	40	bacterial	bacterial	ADJ
admet-286	342	41	density	density	NOUN
admet-286	342	42	e	e	PROPN
admet-286	342	43	pd	pd	PROPN
admet-286	342	44	endpoint	endpoint	VERB
admet-286	342	45	i.e.	i.e.	X
admet-286	342	46	bacterial	bacterial	ADJ
admet-286	342	47	density	density	NOUN
admet-286	342	48	calculated	calculate	VERB
admet-286	342	49	as	as	ADP
admet-286	342	50	change	change	NOUN
admet-286	342	51	in	in	ADP
admet-286	342	52	log10	log10	PROPN
admet-286	342	53	cfu	cfu	PROPN
admet-286	342	54	/	/	SYM
admet-286	342	55	ml	ml	PROPN
admet-286	342	56	;	;	PUNCT
admet-286	342	57	e0	e0	PROPN
admet-286	342	58	the	the	DET
admet-286	342	59	baseline	baseline	ADJ
admet-286	342	60	effect	effect	NOUN
admet-286	342	61	i.e.	i.e.	X
admet-286	342	62	pd	pd	X
admet-286	342	63	endpoint	endpoint	NOUN
admet-286	342	64	without	without	ADP
admet-286	342	65	antibiotic	antibiotic	ADJ
admet-286	342	66	treatment	treatment	NOUN
admet-286	342	67	;	;	PUNCT
admet-286	342	68	pdmax	pdmax	ADJ
admet-286	342	69	,	,	PUNCT
admet-286	342	70	maximum	maximum	ADJ
admet-286	342	71	effect	effect	NOUN
admet-286	342	72	;	;	PUNCT
admet-286	342	73	x	x	SYM
admet-286	342	74	pk	pk	PROPN
admet-286	342	75	/	/	SYM
admet-286	342	76	pd	pd	PROPN
admet-286	342	77	index	index	NOUN
admet-286	342	78	;	;	PUNCT
admet-286	342	79	ex50	ex50	PROPN
admet-286	342	80	magnitude	magnitude	NOUN
admet-286	342	81	of	of	ADP
admet-286	342	82	x	x	PRON
admet-286	342	83	that	that	PRON
admet-286	342	84	is	be	AUX
admet-286	342	85	needed	need	VERB
admet-286	342	86	to	to	PART
admet-286	342	87	achieve	achieve	VERB
admet-286	342	88	50	50	NUM
admet-286	342	89	%	%	NOUN
admet-286	342	90	of	of	ADP
admet-286	342	91	the	the	DET
admet-286	342	92	pdmax	pdmax	NOUN
admet-286	342	93	;	;	PUNCT
admet-286	342	94	hill	hill	NOUN
admet-286	342	95	sigmoidicity	sigmoidicity	NOUN
admet-286	342	96	factor	factor	NOUN
admet-286	342	97	;	;	PUNCT
admet-286	342	98	fdc	fdc	PROPN
admet-286	342	99	fixed	fix	VERB
admet-286	342	100	dose	dose	NOUN
admet-286	342	101	combination	combination	NOUN
admet-286	342	102	;	;	PUNCT
admet-286	342	103	pd	pd	PROPN
admet-286	342	104	pharmacodynamic	pharmacodynamic	ADJ
admet-286	342	105	;	;	PUNCT
admet-286	342	106	pk	pk	NOUN
admet-286	342	107	pharmacokinetic	pharmacokinetic	NOUN
admet-286	342	108	;	;	PUNCT
admet-286	342	109	mic	mic	ADJ
admet-286	342	110	minimum	minimum	ADJ
admet-286	342	111	inhibitory	inhibitory	ADJ
admet-286	342	112	concentration	concentration	NOUN
admet-286	342	113	,	,	PUNCT
admet-286	342	114	%	%	INTJ
admet-286	342	115	t	t	X
admet-286	342	116	>	>	X
admet-286	342	117	mic	mic	ADJ
admet-286	342	118	%	%	NOUN
admet-286	342	119	time	time	NOUN
admet-286	342	120	for	for	ADP
admet-286	342	121	which	which	PRON
admet-286	342	122	the	the	DET
admet-286	342	123	levels	level	NOUN
admet-286	342	124	of	of	ADP
admet-286	342	125	antibiotic	antibiotic	NOUN
admet-286	342	126	in	in	ADP
admet-286	342	127	serum	serum	NOUN
admet-286	342	128	/	/	SYM
admet-286	342	129	plasma	plasma	NOUN
admet-286	342	130	exceed	exceed	VERB
admet-286	342	131	the	the	DET
admet-286	342	132	mic	mic	NOUN
admet-286	342	133	;	;	PUNCT
admet-286	342	134	auc	auc	ADJ
admet-286	342	135	/	/	SYM
admet-286	342	136	mic	mic	ADJ
admet-286	342	137	area	area	NOUN
admet-286	342	138	under	under	ADP
admet-286	342	139	the	the	DET
admet-286	342	140	concentrationtime	concentrationtime	ADJ
admet-286	342	141	curve	curve	NOUN
admet-286	342	142	/	/	SYM
admet-286	342	143	mic	mic	ADJ
admet-286	342	144	ratio	ratio	NOUN
admet-286	342	145	;	;	PUNCT
admet-286	342	146	cmax	cmax	NOUN
admet-286	342	147	/	/	SYM
admet-286	342	148	mic	mic	ADJ
admet-286	342	149	peak	peak	NOUN
admet-286	342	150	plasma	plasma	NOUN
admet-286	342	151	concentration	concentration	NOUN
admet-286	342	152	/	/	SYM
admet-286	342	153	mic	mic	ADJ
admet-286	342	154	ratio	ratio	NOUN
admet-286	342	155	.	.	PUNCT
admet-286	343	1	admet	admet	PROPN
admet-286	343	2	&	&	CCONJ
admet-286	343	3	dmpk	dmpk	PROPN
admet-286	343	4	4(3	4(3	NUM
admet-286	343	5	)	)	PUNCT
admet-286	343	6	(	(	PUNCT
admet-286	343	7	2016	2016	NUM
admet-286	343	8	)	)	PUNCT
admet-286	343	9	241	241	NUM
admet-286	343	10	-	-	SYM
admet-286	343	11	260	260	NUM
admet-286	343	12	dose	dose	NOUN
admet-286	343	13	optimization	optimization	NOUN
admet-286	343	14	of	of	ADP
admet-286	343	15	fdc	fdc	PROPN
admet-286	343	16	against	against	ADP
admet-286	343	17	s.	s.	PROPN
admet-286	343	18	aureus	aureus	PROPN
admet-286	343	19	resistant	resistant	ADJ
admet-286	343	20	bacteria	bacteria	NOUN
admet-286	343	21	doi	doi	NOUN
admet-286	343	22	:	:	PUNCT
admet-286	343	23	10.5599	10.5599	NUM
admet-286	343	24	/	/	SYM
admet-286	343	25	admet.4.3.286	admet.4.3.286	VERB
admet-286	343	26	259	259	NUM
admet-286	343	27	supplement	supplement	NOUN
admet-286	343	28	figure	figure	NOUN
admet-286	343	29	2	2	NUM
admet-286	343	30	:	:	PUNCT
admet-286	343	31	dose	dose	NOUN
admet-286	343	32	response	response	NOUN
admet-286	343	33	curve	curve	NOUN
admet-286	343	34	of	of	ADP
admet-286	343	35	optimized	optimize	VERB
admet-286	343	36	twice	twice	ADJ
admet-286	343	37	daily	daily	ADJ
admet-286	343	38	regimen	regiman	NOUN
admet-286	343	39	of	of	ADP
admet-286	343	40	fdc	fdc	PROPN
admet-286	343	41	the	the	DET
admet-286	343	42	best	good	ADJ
admet-286	343	43	exposure	exposure	NOUN
admet-286	343	44	from	from	ADP
admet-286	343	45	dose	dose	NOUN
admet-286	343	46	escalation	escalation	NOUN
admet-286	343	47	study	study	NOUN
admet-286	343	48	fractionated	fractionate	VERB
admet-286	343	49	twice	twice	ADV
admet-286	343	50	daily	daily	ADJ
admet-286	343	51	dosage	dosage	NOUN
admet-286	343	52	regimen	regiman	NOUN
admet-286	343	53	of	of	ADP
admet-286	343	54	fdc	fdc	PROPN
admet-286	343	55	enhanced	enhance	VERB
admet-286	343	56	bacterial	bacterial	ADJ
admet-286	343	57	killing	killing	NOUN
admet-286	343	58	.	.	PUNCT
admet-286	344	1	the	the	DET
admet-286	344	2	twice	twice	ADJ
admet-286	344	3	daily	daily	ADJ
admet-286	344	4	regimen	regiman	NOUN
admet-286	344	5	at	at	ADP
admet-286	344	6	75	75	NUM
admet-286	344	7	,	,	PUNCT
admet-286	344	8	50	50	NUM
admet-286	344	9	,	,	PUNCT
admet-286	344	10	38	38	NUM
admet-286	344	11	,	,	PUNCT
admet-286	344	12	and	and	CCONJ
admet-286	344	13	25	25	NUM
admet-286	344	14	%	%	NOUN
admet-286	344	15	of	of	ADP
admet-286	344	16	original	original	ADJ
admet-286	344	17	concentration	concentration	NOUN
admet-286	344	18	and	and	CCONJ
admet-286	344	19	the	the	DET
admet-286	344	20	change	change	NOUN
admet-286	344	21	in	in	ADP
admet-286	344	22	bacterial	bacterial	ADJ
admet-286	344	23	density	density	NOUN
admet-286	344	24	in	in	ADP
admet-286	344	25	24	24	NUM
admet-286	344	26	h	h	NOUN
admet-286	344	27	was	be	AUX
admet-286	344	28	plotted	plot	VERB
admet-286	344	29	to	to	PART
admet-286	344	30	prepare	prepare	VERB
admet-286	344	31	the	the	DET
admet-286	344	32	drc	drc	PROPN
admet-286	344	33	.	.	PUNCT
admet-286	345	1	the	the	DET
admet-286	345	2	drc	drc	PROPN
admet-286	345	3	was	be	AUX
admet-286	345	4	plotted	plot	VERB
admet-286	345	5	between	between	ADP
admet-286	345	6	the	the	DET
admet-286	345	7	dose	dose	NOUN
admet-286	345	8	percentage	percentage	NOUN
admet-286	345	9	and	and	CCONJ
admet-286	345	10	log	log	NOUN
admet-286	345	11	reduction	reduction	NOUN
admet-286	345	12	in	in	ADP
admet-286	345	13	bacterial	bacterial	ADJ
admet-286	345	14	density	density	NOUN
admet-286	345	15	and	and	CCONJ
admet-286	345	16	sigmoidal	sigmoidal	NOUN
admet-286	345	17	function	function	NOUN
admet-286	345	18	was	be	AUX
admet-286	345	19	used	use	VERB
admet-286	345	20	for	for	ADP
admet-286	345	21	curve	curve	NOUN
admet-286	345	22	fitting	fitting	ADJ
admet-286	345	23	.	.	PUNCT
admet-286	346	1	the	the	DET
admet-286	346	2	model	model	NOUN
admet-286	346	3	showed	show	VERB
admet-286	346	4	good	good	ADJ
admet-286	346	5	correlation	correlation	NOUN
admet-286	346	6	(	(	PUNCT
admet-286	346	7	r2=0.9633	r2=0.9633	NUM
admet-286	346	8	)	)	PUNCT
admet-286	346	9	and	and	CCONJ
admet-286	346	10	ec50	ec50	PROPN
admet-286	346	11	of	of	ADP
admet-286	346	12	37.46	37.46	NUM
admet-286	346	13	%	%	NOUN
admet-286	346	14	was	be	AUX
admet-286	346	15	estimated	estimate	VERB
admet-286	346	16	.	.	PUNCT
admet-286	347	1	ec50	ec50	ADJ
admet-286	347	2	percentage	percentage	NOUN
admet-286	347	3	of	of	ADP
admet-286	347	4	dose	dose	NOUN
admet-286	347	5	required	require	VERB
admet-286	347	6	to	to	PART
admet-286	347	7	attain	attain	VERB
admet-286	347	8	the	the	DET
admet-286	347	9	50	50	NUM
admet-286	347	10	%	%	NOUN
admet-286	347	11	of	of	ADP
admet-286	347	12	pd	pd	PROPN
admet-286	347	13	effect	effect	NOUN
admet-286	347	14	;	;	PUNCT
admet-286	347	15	fdc	fdc	PROPN
admet-286	347	16	fixed	fix	VERB
admet-286	347	17	dose	dose	NOUN
admet-286	347	18	combination	combination	NOUN
admet-286	347	19	;	;	PUNCT
admet-286	347	20	drc	drc	PROPN
admet-286	347	21	dose	dose	VERB
admet-286	347	22	response	response	NOUN
admet-286	347	23	curve	curve	NOUN
admet-286	347	24	;	;	PUNCT
admet-286	347	25	pd	pd	NOUN
admet-286	347	26	pharmacodynamics	pharmacodynamic	NOUN
admet-286	347	27	.	.	PUNCT
admet-286	348	1	supplement	supplement	NOUN
admet-286	348	2	figure	figure	NOUN
admet-286	348	3	3	3	NUM
admet-286	348	4	:	:	PUNCT
admet-286	348	5	breakpoint	breakpoint	NOUN
admet-286	348	6	analysis	analysis	NOUN
admet-286	348	7	of	of	ADP
admet-286	348	8	fixed	fix	VERB
admet-286	348	9	dose	dose	NOUN
admet-286	348	10	combination	combination	NOUN
admet-286	348	11	of	of	ADP
admet-286	348	12	ceftriaxone	ceftriaxone	NOUN
admet-286	348	13	and	and	CCONJ
admet-286	348	14	vancomycin	vancomycin	PROPN
admet-286	348	15	against	against	ADP
admet-286	348	16	150	150	NUM
admet-286	348	17	mrsa	mrsa	NOUN
admet-286	348	18	strains	strain	VERB
admet-286	348	19	the	the	DET
admet-286	348	20	in	in	X
admet-286	348	21	vitro	vitro	X
admet-286	348	22	susceptibility	susceptibility	NOUN
admet-286	348	23	tests	test	NOUN
admet-286	348	24	categorize	categorize	VERB
admet-286	348	25	the	the	DET
admet-286	348	26	bacterial	bacterial	ADJ
admet-286	348	27	isolates	isolate	NOUN
admet-286	348	28	into	into	ADP
admet-286	348	29	three	three	NUM
admet-286	348	30	categories	category	NOUN
admet-286	348	31	:	:	PUNCT
admet-286	348	32	susceptible	susceptible	ADJ
admet-286	348	33	(	(	PUNCT
admet-286	348	34	s	s	NOUN
admet-286	348	35	)	)	PUNCT
admet-286	348	36	,	,	PUNCT
admet-286	348	37	intermediate	intermediate	ADJ
admet-286	348	38	(	(	PUNCT
admet-286	348	39	i	i	NOUN
admet-286	348	40	)	)	PUNCT
admet-286	348	41	,	,	PUNCT
admet-286	348	42	and	and	CCONJ
admet-286	348	43	resistant	resistant	ADJ
admet-286	348	44	(	(	PUNCT
admet-286	348	45	r	r	NOUN
admet-286	348	46	)	)	PUNCT
admet-286	348	47	.	.	PUNCT
admet-286	349	1	the	the	DET
admet-286	349	2	mic	mic	ADJ
admet-286	349	3	breakpoints	breakpoint	NOUN
admet-286	349	4	was	be	AUX
admet-286	349	5	determined	determine	VERB
admet-286	349	6	on	on	ADP
admet-286	349	7	the	the	DET
admet-286	349	8	basis	basis	NOUN
admet-286	349	9	of	of	ADP
admet-286	349	10	attainment	attainment	NOUN
admet-286	349	11	of	of	ADP
admet-286	349	12	pk	pk	NOUN
admet-286	349	13	/	/	SYM
admet-286	349	14	pd	pd	NOUN
admet-286	349	15	index	index	NOUN
admet-286	349	16	%	%	NOUN
admet-286	349	17	t	t	PROPN
admet-286	349	18	>	>	X
admet-286	349	19	mic	mic	PROPN
admet-286	349	20	≈50%t	≈50%t	NOUN
admet-286	349	21	>	>	X
admet-286	349	22	mic	mic	NOUN
admet-286	349	23	.	.	PUNCT
admet-286	350	1	the	the	DET
admet-286	350	2	plot	plot	NOUN
admet-286	350	3	of	of	ADP
admet-286	350	4	mic	mic	ADJ
admet-286	350	5	values	value	NOUN
admet-286	350	6	of	of	ADP
admet-286	350	7	various	various	ADJ
admet-286	350	8	strains	strain	NOUN
admet-286	350	9	against	against	ADP
admet-286	350	10	the	the	DET
admet-286	350	11	zone	zone	NOUN
admet-286	350	12	diameter	diameter	NOUN
admet-286	350	13	(	(	PUNCT
admet-286	350	14	ast	ast	PROPN
admet-286	350	15	)	)	PUNCT
admet-286	350	16	for	for	ADP
admet-286	350	17	mrsa	mrsa	NOUN
admet-286	350	18	and	and	CCONJ
admet-286	350	19	segregated	segregate	VERB
admet-286	350	20	based	base	VERB
admet-286	350	21	on	on	ADP
admet-286	350	22	the	the	DET
admet-286	350	23	mic	mic	ADJ
admet-286	350	24	breakpoints	breakpoint	NOUN
admet-286	350	25	of	of	ADP
admet-286	350	26	4	4	NUM
admet-286	350	27	µg	µg	NOUN
admet-286	350	28	/	/	SYM
admet-286	350	29	ml	ml	NOUN
admet-286	350	30	(	(	PUNCT
admet-286	350	31	s	s	NOUN
admet-286	350	32	)	)	PUNCT
admet-286	350	33	and	and	CCONJ
admet-286	350	34	32	32	NUM
admet-286	350	35	µg	µg	NOUN
admet-286	350	36	/	/	SYM
admet-286	350	37	ml	ml	NOUN
admet-286	350	38	(	(	PUNCT
admet-286	350	39	r	r	NOUN
admet-286	350	40	)	)	PUNCT
admet-286	350	41	.	.	PUNCT
admet-286	351	1	vishnu	vishnu	PROPN
admet-286	351	2	sharma	sharma	PROPN
admet-286	351	3	et	et	PROPN
admet-286	351	4	al	al	PROPN
admet-286	351	5	.	.	PROPN
admet-286	351	6	admet	admet	PROPN
admet-286	351	7	&	&	CCONJ
admet-286	351	8	dmpk	dmpk	PROPN
admet-286	351	9	4(3	4(3	NUM
admet-286	351	10	)	)	PUNCT
admet-286	351	11	(	(	PUNCT
admet-286	351	12	2016	2016	NUM
admet-286	351	13	)	)	PUNCT
admet-286	351	14	241	241	NUM
admet-286	351	15	-	-	SYM
admet-286	351	16	260	260	NUM
admet-286	351	17	260	260	NUM
admet-286	351	18	ast	ast	NOUN
admet-286	351	19	antimicrobial	antimicrobial	ADJ
admet-286	351	20	susceptibility	susceptibility	NOUN
admet-286	351	21	;	;	PUNCT
admet-286	351	22	mic	mic	ADJ
admet-286	351	23	minimum	minimum	ADJ
admet-286	351	24	inhibitory	inhibitory	ADJ
admet-286	351	25	concentration	concentration	NOUN
admet-286	351	26	,	,	PUNCT
admet-286	351	27	%	%	INTJ
admet-286	351	28	t	t	X
admet-286	351	29	>	>	X
admet-286	351	30	mic	mic	ADJ
admet-286	351	31	%	%	NOUN
admet-286	351	32	time	time	NOUN
admet-286	351	33	for	for	ADP
admet-286	351	34	which	which	PRON
admet-286	351	35	the	the	DET
admet-286	351	36	levels	level	NOUN
admet-286	351	37	of	of	ADP
admet-286	351	38	antibiotic	antibiotic	NOUN
admet-286	351	39	in	in	ADP
admet-286	351	40	serum	serum	NOUN
admet-286	351	41	/	/	SYM
admet-286	351	42	plasma	plasma	NOUN
admet-286	351	43	exceed	exceed	VERB
admet-286	351	44	the	the	DET
admet-286	351	45	mic	mic	ADJ
admet-286	351	46	©	©	PROPN
admet-286	351	47	2016	2016	NUM
admet-286	351	48	by	by	ADP
admet-286	351	49	the	the	DET
admet-286	351	50	authors	author	NOUN
admet-286	351	51	;	;	PUNCT
admet-286	351	52	licensee	licensee	PROPN
admet-286	351	53	iapc	iapc	PROPN
admet-286	351	54	,	,	PUNCT
admet-286	351	55	zagreb	zagreb	PROPN
admet-286	351	56	,	,	PUNCT
admet-286	351	57	croatia	croatia	PROPN
admet-286	351	58	.	.	PUNCT
admet-286	352	1	this	this	DET
admet-286	352	2	article	article	NOUN
admet-286	352	3	is	be	AUX
admet-286	352	4	an	an	DET
admet-286	352	5	open	open	ADJ
admet-286	352	6	-	-	PUNCT
admet-286	352	7	access	access	NOUN
admet-286	352	8	article	article	NOUN
admet-286	352	9	distributed	distribute	VERB
admet-286	352	10	under	under	ADP
admet-286	352	11	the	the	DET
admet-286	352	12	terms	term	NOUN
admet-286	352	13	and	and	CCONJ
admet-286	352	14	conditions	condition	NOUN
admet-286	352	15	of	of	ADP
admet-286	352	16	the	the	DET
admet-286	352	17	creative	creative	ADJ
admet-286	352	18	commons	common	NOUN
admet-286	352	19	attribution	attribution	NOUN
admet-286	352	20	license	license	NOUN
admet-286	352	21	(	(	PUNCT
admet-286	352	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-286	352	23	)	)	PUNCT
admet-286	352	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN