id	sid	tid	token	lemma	pos
admet-2861	1	1	development	development	NOUN
admet-2861	1	2	of	of	ADP
admet-2861	1	3	a	a	DET
admet-2861	1	4	biorelevant	biorelevant	ADJ
admet-2861	1	5	dissolution	dissolution	NOUN
admet-2861	1	6	method	method	NOUN
admet-2861	1	7	for	for	ADP
admet-2861	1	8	inhalation	inhalation	NOUN
admet-2861	1	9	products	product	NOUN
admet-2861	1	10	:	:	PUNCT
admet-2861	1	11	proof	proof	NOUN
admet-2861	1	12	of	of	ADP
admet-2861	1	13	concept	concept	NOUN
admet-2861	1	14	using	use	VERB
admet-2861	1	15	drugs	drug	NOUN
admet-2861	1	16	with	with	ADP
admet-2861	1	17	diverse	diverse	ADJ
admet-2861	1	18	solubilities	solubility	NOUN
admet-2861	1	19	doi	doi	NOUN
admet-2861	1	20	:	:	PUNCT
admet-2861	1	21	http://dx.doi.org/10.5599/admet.2861	http://dx.doi.org/10.5599/admet.2861	PROPN
admet-2861	1	22	1	1	NUM
admet-2861	1	23	admet	admet	X
admet-2861	1	24	&	&	CCONJ
admet-2861	1	25	dmpk	dmpk	PROPN
admet-2861	1	26	13(5	13(5	NUM
admet-2861	1	27	)	)	PUNCT
admet-2861	1	28	(	(	PUNCT
admet-2861	1	29	2025	2025	NUM
admet-2861	1	30	)	)	PUNCT
admet-2861	1	31	2861	2861	NUM
admet-2861	1	32	;	;	PUNCT
admet-2861	1	33	doi	doi	NOUN
admet-2861	1	34	:	:	PUNCT
admet-2861	1	35	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	1	36	open	open	ADJ
admet-2861	1	37	access	access	NOUN
admet-2861	1	38	:	:	PUNCT
admet-2861	1	39	issn	issn	PROPN
admet-2861	1	40	:	:	PUNCT
admet-2861	1	41	1848	1848	NUM
admet-2861	1	42	-	-	SYM
admet-2861	1	43	7718	7718	NUM
admet-2861	1	44	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	PROPN
admet-2861	1	45	original	original	ADJ
admet-2861	1	46	scientific	scientific	ADJ
admet-2861	1	47	paper	paper	NOUN
admet-2861	1	48	development	development	NOUN
admet-2861	1	49	of	of	ADP
admet-2861	1	50	a	a	DET
admet-2861	1	51	biorelevant	biorelevant	ADJ
admet-2861	1	52	dissolution	dissolution	NOUN
admet-2861	1	53	method	method	NOUN
admet-2861	1	54	for	for	ADP
admet-2861	1	55	inhalation	inhalation	NOUN
admet-2861	1	56	products	product	NOUN
admet-2861	1	57	:	:	PUNCT
admet-2861	1	58	proof	proof	NOUN
admet-2861	1	59	of	of	ADP
admet-2861	1	60	concept	concept	NOUN
admet-2861	1	61	using	use	VERB
admet-2861	1	62	drugs	drug	NOUN
admet-2861	1	63	with	with	ADP
admet-2861	1	64	diverse	diverse	ADJ
admet-2861	1	65	solubilities	solubility	NOUN
admet-2861	1	66	amar	amar	PROPN
admet-2861	1	67	elezović1	elezović1	PROPN
admet-2861	1	68	,	,	PUNCT
admet-2861	1	69	*	*	PROPN
admet-2861	1	70	,	,	PUNCT
admet-2861	1	71	sandra	sandra	PROPN
admet-2861	1	72	cvijić2	cvijić2	PROPN
admet-2861	1	73	,	,	PUNCT
admet-2861	1	74	saša	saša	PROPN
admet-2861	1	75	pilipović1	pilipović1	PROPN
admet-2861	1	76	,	,	PUNCT
admet-2861	1	77	alisa	alisa	PROPN
admet-2861	1	78	elezović3	elezović3	NOUN
admet-2861	1	79	and	and	CCONJ
admet-2861	1	80	jelena	jelena	PROPN
admet-2861	1	81	parojčić2	parojčić2	PROPN
admet-2861	2	1	1control	1control	NUM
admet-2861	2	2	laboratory	laboratory	NOUN
admet-2861	2	3	of	of	ADP
admet-2861	2	4	agency	agency	NOUN
admet-2861	2	5	for	for	ADP
admet-2861	2	6	medicinal	medicinal	ADJ
admet-2861	2	7	products	product	NOUN
admet-2861	2	8	and	and	CCONJ
admet-2861	2	9	medical	medical	ADJ
admet-2861	2	10	devices	device	NOUN
admet-2861	2	11	of	of	ADP
admet-2861	2	12	bosnia	bosnia	PROPN
admet-2861	2	13	and	and	CCONJ
admet-2861	2	14	herzegovina	herzegovina	PROPN
admet-2861	2	15	,	,	PUNCT
admet-2861	2	16	maršala	maršala	PROPN
admet-2861	2	17	tita	tita	PROPN
admet-2861	2	18	9	9	NUM
admet-2861	2	19	,	,	PUNCT
admet-2861	2	20	sarajevo	sarajevo	PROPN
admet-2861	2	21	,	,	PUNCT
admet-2861	2	22	bosnia	bosnia	PROPN
admet-2861	2	23	and	and	CCONJ
admet-2861	2	24	herzegovina	herzegovina	PROPN
admet-2861	2	25	2university	2university	NUM
admet-2861	2	26	of	of	ADP
admet-2861	2	27	belgrade	belgrade	PROPN
admet-2861	2	28	–	–	PUNCT
admet-2861	2	29	faculty	faculty	NOUN
admet-2861	2	30	of	of	ADP
admet-2861	2	31	pharmacy	pharmacy	NOUN
admet-2861	2	32	,	,	PUNCT
admet-2861	2	33	department	department	NOUN
admet-2861	2	34	of	of	ADP
admet-2861	2	35	pharmaceutical	pharmaceutical	NOUN
admet-2861	2	36	technology	technology	NOUN
admet-2861	2	37	and	and	CCONJ
admet-2861	2	38	cosmetology	cosmetology	NOUN
admet-2861	2	39	,	,	PUNCT
admet-2861	2	40	vojvode	vojvode	ADJ
admet-2861	2	41	stepe	stepe	NOUN
admet-2861	2	42	450	450	NUM
admet-2861	2	43	,	,	PUNCT
admet-2861	2	44	beograd	beograd	PROPN
admet-2861	2	45	,	,	PUNCT
admet-2861	2	46	serbia	serbia	PROPN
admet-2861	2	47	3university	3university	PROPN
admet-2861	2	48	of	of	ADP
admet-2861	2	49	sarajevo	sarajevo	PROPN
admet-2861	2	50	–	–	PUNCT
admet-2861	2	51	faculty	faculty	NOUN
admet-2861	2	52	of	of	ADP
admet-2861	2	53	pharmacy	pharmacy	NOUN
admet-2861	2	54	,	,	PUNCT
admet-2861	2	55	department	department	NOUN
admet-2861	2	56	of	of	ADP
admet-2861	2	57	pharmaceutical	pharmaceutical	NOUN
admet-2861	2	58	technology	technology	NOUN
admet-2861	2	59	,	,	PUNCT
admet-2861	2	60	zmaja	zmaja	PROPN
admet-2861	2	61	od	od	PROPN
admet-2861	2	62	bosne	bosne	PROPN
admet-2861	2	63	8	8	NUM
admet-2861	2	64	,	,	PUNCT
admet-2861	2	65	sarajevo	sarajevo	PROPN
admet-2861	2	66	,	,	PUNCT
admet-2861	2	67	bosnia	bosnia	PROPN
admet-2861	2	68	and	and	CCONJ
admet-2861	2	69	herzegovina	herzegovina	PROPN
admet-2861	2	70	*	*	PUNCT
admet-2861	2	71	corresponding	correspond	VERB
admet-2861	2	72	author	author	NOUN
admet-2861	2	73	:	:	PUNCT
admet-2861	2	74	e	e	NOUN
admet-2861	2	75	-	-	NOUN
admet-2861	2	76	mail	mail	NOUN
admet-2861	2	77	:	:	PUNCT
admet-2861	2	78	a.elezovic@almbih.gov.ba	a.elezovic@almbih.gov.ba	NOUN
admet-2861	2	79	;	;	PUNCT
admet-2861	2	80	tel	tel	PROPN
admet-2861	2	81	.	.	PUNCT
admet-2861	2	82	:	:	PUNCT
admet-2861	3	1	+387	+387	NOUN
admet-2861	3	2	61	61	NUM
admet-2861	3	3	214	214	NUM
admet-2861	3	4	981	981	NUM
admet-2861	3	5	received	receive	VERB
admet-2861	3	6	:	:	PUNCT
admet-2861	3	7	june	june	PROPN
admet-2861	3	8	7	7	NUM
admet-2861	3	9	,	,	PUNCT
admet-2861	3	10	2025	2025	NUM
admet-2861	3	11	;	;	PUNCT
admet-2861	3	12	revised	revise	VERB
admet-2861	3	13	:	:	PUNCT
admet-2861	3	14	august	august	PROPN
admet-2861	3	15	25	25	NUM
admet-2861	3	16	,	,	PUNCT
admet-2861	3	17	2025	2025	NUM
admet-2861	3	18	;	;	PUNCT
admet-2861	3	19	published	publish	VERB
admet-2861	3	20	:	:	PUNCT
admet-2861	3	21	september	september	PROPN
admet-2861	3	22	4	4	NUM
admet-2861	3	23	,	,	PUNCT
admet-2861	3	24	2025	2025	NUM
admet-2861	3	25	abstract	abstract	ADJ
admet-2861	3	26	background	background	NOUN
admet-2861	3	27	and	and	CCONJ
admet-2861	3	28	purpose	purpose	NOUN
admet-2861	3	29	:	:	PUNCT
admet-2861	3	30	due	due	ADP
admet-2861	3	31	to	to	ADP
admet-2861	3	32	their	their	PRON
admet-2861	3	33	unique	unique	ADJ
admet-2861	3	34	application	application	NOUN
admet-2861	3	35	and	and	CCONJ
admet-2861	3	36	action	action	NOUN
admet-2861	3	37	,	,	PUNCT
admet-2861	3	38	inhalation	inhalation	NOUN
admet-2861	3	39	products	product	NOUN
admet-2861	3	40	require	require	VERB
admet-2861	3	41	specific	specific	ADJ
admet-2861	3	42	quality	quality	NOUN
admet-2861	3	43	tests	test	NOUN
admet-2861	3	44	,	,	PUNCT
admet-2861	3	45	such	such	ADJ
admet-2861	3	46	as	as	ADP
admet-2861	3	47	uniformity	uniformity	NOUN
admet-2861	3	48	of	of	ADP
admet-2861	3	49	delivered	deliver	VERB
admet-2861	3	50	dose	dose	NOUN
admet-2861	3	51	and	and	CCONJ
admet-2861	3	52	aerodynamic	aerodynamic	ADJ
admet-2861	3	53	assessment	assessment	NOUN
admet-2861	3	54	of	of	ADP
admet-2861	3	55	fine	fine	ADJ
admet-2861	3	56	particles	particle	NOUN
admet-2861	3	57	.	.	PUNCT
admet-2861	4	1	while	while	SCONJ
admet-2861	4	2	there	there	PRON
admet-2861	4	3	's	be	VERB
admet-2861	4	4	no	no	DET
admet-2861	4	5	current	current	ADJ
admet-2861	4	6	official	official	ADJ
admet-2861	4	7	requirement	requirement	NOUN
admet-2861	4	8	for	for	ADP
admet-2861	4	9	dissolution	dissolution	NOUN
admet-2861	4	10	tests	test	NOUN
admet-2861	4	11	,	,	PUNCT
admet-2861	4	12	new	new	ADJ
admet-2861	4	13	draft	draft	NOUN
admet-2861	4	14	guidelines	guideline	NOUN
admet-2861	4	15	are	be	AUX
admet-2861	4	16	introducing	introduce	VERB
admet-2861	4	17	them	they	PRON
admet-2861	4	18	as	as	ADP
admet-2861	4	19	a	a	DET
admet-2861	4	20	supportive	supportive	ADJ
admet-2861	4	21	or	or	CCONJ
admet-2861	4	22	required	required	ADJ
admet-2861	4	23	measure	measure	NOUN
admet-2861	4	24	;	;	PUNCT
admet-2861	4	25	however	however	ADV
admet-2861	4	26	,	,	PUNCT
admet-2861	4	27	a	a	DET
admet-2861	4	28	universally	universally	ADV
admet-2861	4	29	accepted	accept	VERB
admet-2861	4	30	methodology	methodology	NOUN
admet-2861	4	31	for	for	ADP
admet-2861	4	32	such	such	ADJ
admet-2861	4	33	testing	testing	NOUN
admet-2861	4	34	remains	remain	VERB
admet-2861	4	35	elusive	elusive	ADJ
admet-2861	4	36	.	.	PUNCT
admet-2861	5	1	the	the	DET
admet-2861	5	2	aim	aim	NOUN
admet-2861	5	3	of	of	ADP
admet-2861	5	4	the	the	DET
admet-2861	5	5	present	present	ADJ
admet-2861	5	6	study	study	NOUN
admet-2861	5	7	was	be	AUX
admet-2861	5	8	to	to	PART
admet-2861	5	9	explore	explore	VERB
admet-2861	5	10	the	the	DET
admet-2861	5	11	discriminatory	discriminatory	ADJ
admet-2861	5	12	ability	ability	NOUN
admet-2861	5	13	and	and	CCONJ
admet-2861	5	14	in	in	ADP
admet-2861	5	15	vivo	vivo	ADJ
admet-2861	5	16	predictability	predictability	NOUN
admet-2861	5	17	of	of	ADP
admet-2861	5	18	the	the	DET
admet-2861	5	19	newly	newly	ADV
admet-2861	5	20	developed	develop	VERB
admet-2861	5	21	dissolution	dissolution	NOUN
admet-2861	5	22	assembly	assembly	NOUN
admet-2861	5	23	.	.	PUNCT
admet-2861	6	1	experimental	experimental	ADJ
admet-2861	6	2	approach	approach	NOUN
admet-2861	6	3	:	:	PUNCT
admet-2861	6	4	the	the	DET
admet-2861	6	5	applied	apply	VERB
admet-2861	6	6	experimental	experimental	ADJ
admet-2861	6	7	approach	approach	NOUN
admet-2861	6	8	to	to	ADP
admet-2861	6	9	biopharmaceutical	biopharmaceutical	ADJ
admet-2861	6	10	characterization	characterization	NOUN
admet-2861	6	11	of	of	ADP
admet-2861	6	12	inhalation	inhalation	NOUN
admet-2861	6	13	products	product	NOUN
admet-2861	6	14	involved	involve	VERB
admet-2861	6	15	developing	develop	VERB
admet-2861	6	16	a	a	DET
admet-2861	6	17	biorelevant	biorelevant	NOUN
admet-2861	6	18	method	method	NOUN
admet-2861	6	19	for	for	ADP
admet-2861	6	20	testing	test	VERB
admet-2861	6	21	the	the	DET
admet-2861	6	22	dissolution	dissolution	NOUN
admet-2861	6	23	rate	rate	NOUN
admet-2861	6	24	of	of	ADP
admet-2861	6	25	the	the	DET
admet-2861	6	26	selected	select	VERB
admet-2861	6	27	active	active	ADJ
admet-2861	6	28	substances	substance	NOUN
admet-2861	6	29	.	.	PUNCT
admet-2861	7	1	seven	seven	NUM
admet-2861	7	2	commercially	commercially	ADV
admet-2861	7	3	available	available	ADJ
admet-2861	7	4	products	product	NOUN
admet-2861	7	5	,	,	PUNCT
admet-2861	7	6	formulated	formulate	VERB
admet-2861	7	7	as	as	ADP
admet-2861	7	8	pressurized	pressurize	VERB
admet-2861	7	9	metered	meter	VERB
admet-2861	7	10	dose	dose	NOUN
admet-2861	7	11	inhalers	inhaler	NOUN
admet-2861	7	12	,	,	PUNCT
admet-2861	7	13	containing	contain	VERB
admet-2861	7	14	either	either	CCONJ
admet-2861	7	15	salmeterol	salmeterol	NOUN
admet-2861	7	16	xinafoate	xinafoate	ADJ
admet-2861	7	17	or	or	CCONJ
admet-2861	7	18	beclomethasone	beclomethasone	ADJ
admet-2861	7	19	dipropionate	dipropionate	NOUN
admet-2861	7	20	,	,	PUNCT
admet-2861	7	21	have	have	AUX
admet-2861	7	22	been	be	AUX
admet-2861	7	23	studied	study	VERB
admet-2861	7	24	.	.	PUNCT
admet-2861	8	1	the	the	DET
admet-2861	8	2	research	research	NOUN
admet-2861	8	3	strategy	strategy	NOUN
admet-2861	8	4	combined	combine	VERB
admet-2861	8	5	in	in	ADP
admet-2861	8	6	vitro	vitro	X
admet-2861	8	7	testing	testing	NOUN
admet-2861	8	8	within	within	ADP
admet-2861	8	9	silico	silico	NOUN
admet-2861	8	10	simulations	simulation	NOUN
admet-2861	8	11	.	.	PUNCT
admet-2861	9	1	key	key	ADJ
admet-2861	9	2	results	result	NOUN
admet-2861	9	3	:	:	PUNCT
admet-2861	9	4	the	the	DET
admet-2861	9	5	developed	develop	VERB
admet-2861	9	6	dissolution	dissolution	NOUN
admet-2861	9	7	method	method	NOUN
admet-2861	9	8	did	do	AUX
admet-2861	9	9	not	not	PART
admet-2861	9	10	detect	detect	VERB
admet-2861	9	11	significant	significant	ADJ
admet-2861	9	12	differences	difference	NOUN
admet-2861	9	13	in	in	ADP
admet-2861	9	14	the	the	DET
admet-2861	9	15	case	case	NOUN
admet-2861	9	16	of	of	ADP
admet-2861	9	17	products	product	NOUN
admet-2861	9	18	containing	contain	VERB
admet-2861	9	19	highly	highly	ADV
admet-2861	9	20	soluble	soluble	ADJ
admet-2861	9	21	salmeterol	salmeterol	NOUN
admet-2861	9	22	,	,	PUNCT
admet-2861	9	23	but	but	CCONJ
admet-2861	9	24	it	it	PRON
admet-2861	9	25	did	do	AUX
admet-2861	9	26	reveal	reveal	VERB
admet-2861	9	27	differences	difference	NOUN
admet-2861	9	28	for	for	ADP
admet-2861	9	29	products	product	NOUN
admet-2861	9	30	containing	contain	VERB
admet-2861	9	31	poorly	poorly	ADV
admet-2861	9	32	soluble	soluble	ADJ
admet-2861	9	33	beclomethasone	beclomethasone	NOUN
admet-2861	9	34	dipropionate	dipropionate	NOUN
admet-2861	9	35	.	.	PUNCT
admet-2861	10	1	moreover	moreover	ADV
admet-2861	10	2	,	,	PUNCT
admet-2861	10	3	a	a	DET
admet-2861	10	4	correlation	correlation	NOUN
admet-2861	10	5	was	be	AUX
admet-2861	10	6	identified	identify	VERB
admet-2861	10	7	between	between	ADP
admet-2861	10	8	the	the	DET
admet-2861	10	9	dissolution	dissolution	NOUN
admet-2861	10	10	test	test	NOUN
admet-2861	10	11	results	result	NOUN
admet-2861	10	12	and	and	CCONJ
admet-2861	10	13	absorption	absorption	NOUN
admet-2861	10	14	constants	constant	NOUN
admet-2861	10	15	for	for	ADP
admet-2861	10	16	beclomethasone	beclomethasone	NOUN
admet-2861	10	17	dipropionate	dipropionate	NOUN
admet-2861	10	18	.	.	PUNCT
admet-2861	11	1	conclusion	conclusion	NOUN
admet-2861	11	2	:	:	PUNCT
admet-2861	11	3	the	the	DET
admet-2861	11	4	obtained	obtain	VERB
admet-2861	11	5	results	result	NOUN
admet-2861	11	6	indicated	indicate	VERB
admet-2861	11	7	that	that	SCONJ
admet-2861	11	8	the	the	DET
admet-2861	11	9	investigated	investigate	VERB
admet-2861	11	10	products	product	NOUN
admet-2861	11	11	would	would	AUX
admet-2861	11	12	not	not	PART
admet-2861	11	13	be	be	AUX
admet-2861	11	14	considered	consider	VERB
admet-2861	11	15	bioequivalent	bioequivalent	NOUN
admet-2861	11	16	based	base	VERB
admet-2861	11	17	on	on	ADP
admet-2861	11	18	the	the	DET
admet-2861	11	19	aerodynamic	aerodynamic	ADJ
admet-2861	11	20	particle	particle	NOUN
admet-2861	11	21	size	size	NOUN
admet-2861	11	22	distribution	distribution	NOUN
admet-2861	11	23	.	.	PUNCT
admet-2861	12	1	it	it	PRON
admet-2861	12	2	was	be	AUX
admet-2861	12	3	demonstrated	demonstrate	VERB
admet-2861	12	4	that	that	SCONJ
admet-2861	12	5	a	a	DET
admet-2861	12	6	discriminative	discriminative	NOUN
admet-2861	12	7	dissolution	dissolution	NOUN
admet-2861	12	8	method	method	NOUN
admet-2861	12	9	can	can	AUX
admet-2861	12	10	be	be	AUX
admet-2861	12	11	developed	develop	VERB
admet-2861	12	12	through	through	ADP
admet-2861	12	13	a	a	DET
admet-2861	12	14	wellestablished	wellestablished	ADJ
admet-2861	12	15	paradigm	paradigm	NOUN
admet-2861	12	16	of	of	ADP
admet-2861	12	17	dissolution	dissolution	NOUN
admet-2861	12	18	testing	testing	NOUN
admet-2861	12	19	,	,	PUNCT
admet-2861	12	20	while	while	SCONJ
admet-2861	12	21	taking	take	VERB
admet-2861	12	22	into	into	ADP
admet-2861	12	23	account	account	NOUN
admet-2861	12	24	the	the	DET
admet-2861	12	25	specificities	specificity	NOUN
admet-2861	12	26	of	of	ADP
admet-2861	12	27	the	the	DET
admet-2861	12	28	inhalation	inhalation	NOUN
admet-2861	12	29	route	route	NOUN
admet-2861	12	30	of	of	ADP
admet-2861	12	31	administration	administration	NOUN
admet-2861	12	32	.	.	PUNCT
admet-2861	13	1	©	©	PROPN
admet-2861	13	2	2025	2025	NUM
admet-2861	13	3	by	by	ADP
admet-2861	13	4	the	the	DET
admet-2861	13	5	authors	author	NOUN
admet-2861	13	6	.	.	PUNCT
admet-2861	14	1	this	this	DET
admet-2861	14	2	article	article	NOUN
admet-2861	14	3	is	be	AUX
admet-2861	14	4	an	an	DET
admet-2861	14	5	open	open	ADJ
admet-2861	14	6	-	-	PUNCT
admet-2861	14	7	access	access	NOUN
admet-2861	14	8	article	article	NOUN
admet-2861	14	9	distributed	distribute	VERB
admet-2861	14	10	under	under	ADP
admet-2861	14	11	the	the	DET
admet-2861	14	12	terms	term	NOUN
admet-2861	14	13	and	and	CCONJ
admet-2861	14	14	conditions	condition	NOUN
admet-2861	14	15	of	of	ADP
admet-2861	14	16	the	the	DET
admet-2861	14	17	creative	creative	ADJ
admet-2861	14	18	commons	common	NOUN
admet-2861	14	19	attribution	attribution	NOUN
admet-2861	14	20	license	license	NOUN
admet-2861	14	21	(	(	PUNCT
admet-2861	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2861	14	23	)	)	PUNCT
admet-2861	14	24	.	.	PUNCT
admet-2861	15	1	keywords	keyword	VERB
admet-2861	15	2	inhalers	inhaler	NOUN
admet-2861	15	3	;	;	PUNCT
admet-2861	15	4	pressurized	pressurize	VERB
admet-2861	15	5	metered	meter	VERB
admet-2861	15	6	dose	dose	NOUN
admet-2861	15	7	inhalers	inhaler	NOUN
admet-2861	15	8	;	;	PUNCT
admet-2861	15	9	dissolution	dissolution	NOUN
admet-2861	15	10	;	;	PUNCT
admet-2861	15	11	in	in	ADP
admet-2861	15	12	vivo	vivo	NOUN
admet-2861	15	13	-	-	PUNCT
admet-2861	15	14	in	in	ADP
admet-2861	15	15	vitro	vitro	X
admet-2861	15	16	-	-	PUNCT
admet-2861	15	17	in	in	ADP
admet-2861	15	18	silico	silico	NOUN
admet-2861	15	19	correlation	correlation	NOUN
admet-2861	15	20	introduction	introduction	NOUN
admet-2861	15	21	inhalation	inhalation	NOUN
admet-2861	15	22	products	product	NOUN
admet-2861	15	23	are	be	AUX
admet-2861	15	24	,	,	PUNCT
admet-2861	15	25	in	in	ADP
admet-2861	15	26	many	many	ADJ
admet-2861	15	27	ways	way	NOUN
admet-2861	15	28	,	,	PUNCT
admet-2861	15	29	specific	specific	ADJ
admet-2861	15	30	pharmaceutical	pharmaceutical	ADJ
admet-2861	15	31	products	product	NOUN
admet-2861	15	32	.	.	PUNCT
admet-2861	16	1	the	the	DET
admet-2861	16	2	method	method	NOUN
admet-2861	16	3	of	of	ADP
admet-2861	16	4	application	application	NOUN
admet-2861	16	5	and	and	CCONJ
admet-2861	16	6	the	the	DET
admet-2861	16	7	place	place	NOUN
admet-2861	16	8	of	of	ADP
admet-2861	16	9	action	action	NOUN
admet-2861	16	10	determine	determine	VERB
admet-2861	16	11	the	the	DET
admet-2861	16	12	particularity	particularity	NOUN
admet-2861	16	13	,	,	PUNCT
admet-2861	16	14	both	both	CCONJ
admet-2861	16	15	in	in	ADP
admet-2861	16	16	the	the	DET
admet-2861	16	17	technological	technological	ADJ
admet-2861	16	18	and	and	CCONJ
admet-2861	16	19	analytical	analytical	ADJ
admet-2861	16	20	sense	sense	NOUN
admet-2861	16	21	.	.	PUNCT
admet-2861	17	1	these	these	DET
admet-2861	17	2	specificities	specificity	NOUN
admet-2861	17	3	require	require	VERB
admet-2861	17	4	specific	specific	ADJ
admet-2861	17	5	quality	quality	NOUN
admet-2861	17	6	tests	test	NOUN
admet-2861	17	7	that	that	PRON
admet-2861	17	8	ensure	ensure	VERB
admet-2861	17	9	the	the	DET
admet-2861	17	10	performance	performance	NOUN
admet-2861	17	11	and	and	CCONJ
admet-2861	17	12	quality	quality	NOUN
admet-2861	17	13	of	of	ADP
admet-2861	17	14	a	a	DET
admet-2861	17	15	drug	drug	NOUN
admet-2861	17	16	product	product	NOUN
admet-2861	17	17	.	.	PUNCT
admet-2861	18	1	specific	specific	ADJ
admet-2861	18	2	tests	test	NOUN
admet-2861	18	3	,	,	PUNCT
admet-2861	18	4	along	along	ADP
admet-2861	18	5	with	with	ADP
admet-2861	18	6	the	the	DET
admet-2861	18	7	necessary	necessary	ADJ
admet-2861	18	8	equipment	equipment	NOUN
admet-2861	18	9	for	for	ADP
admet-2861	18	10	their	their	PRON
admet-2861	18	11	implementation	implementation	NOUN
admet-2861	18	12	,	,	PUNCT
admet-2861	18	13	enable	enable	VERB
admet-2861	18	14	control	control	NOUN
admet-2861	18	15	over	over	ADP
admet-2861	18	16	the	the	DET
admet-2861	18	17	quality	quality	NOUN
admet-2861	18	18	parameters	parameter	NOUN
admet-2861	18	19	of	of	ADP
admet-2861	18	20	inhalation	inhalation	NOUN
admet-2861	18	21	preparations	preparation	NOUN
admet-2861	18	22	,	,	PUNCT
admet-2861	18	23	which	which	PRON
admet-2861	18	24	are	be	AUX
admet-2861	18	25	,	,	PUNCT
admet-2861	18	26	on	on	ADP
admet-2861	18	27	the	the	DET
admet-2861	18	28	one	one	NUM
admet-2861	18	29	hand	hand	NOUN
admet-2861	18	30	,	,	PUNCT
admet-2861	18	31	specific	specific	ADJ
admet-2861	18	32	to	to	ADP
admet-2861	18	33	these	these	DET
admet-2861	18	34	dosage	dosage	NOUN
admet-2861	18	35	forms	form	NOUN
admet-2861	18	36	and	and	CCONJ
admet-2861	18	37	,	,	PUNCT
admet-2861	18	38	on	on	ADP
admet-2861	18	39	the	the	DET
admet-2861	18	40	other	other	ADJ
admet-2861	18	41	hand	hand	NOUN
admet-2861	18	42	,	,	PUNCT
admet-2861	18	43	http://dx.doi.org/10.5599/admet.2861	http://dx.doi.org/10.5599/admet.2861	PROPN
admet-2861	18	44	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	19	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2861	19	2	mailto:a.elezovic@almbih.gov.ba	mailto:a.elezovic@almbih.gov.ba	PROPN
admet-2861	19	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2861	19	4	a.	a.	PROPN
admet-2861	19	5	elezović	elezović	PROPN
admet-2861	19	6	et	et	PROPN
admet-2861	19	7	al	al	PROPN
admet-2861	19	8	.	.	PROPN
admet-2861	19	9	admet	admet	PROPN
admet-2861	19	10	&	&	CCONJ
admet-2861	19	11	dmpk	dmpk	PROPN
admet-2861	19	12	13(5	13(5	NUM
admet-2861	19	13	)	)	PUNCT
admet-2861	19	14	(	(	PUNCT
admet-2861	19	15	2025	2025	NUM
admet-2861	19	16	)	)	PUNCT
admet-2861	19	17	2861	2861	NUM
admet-2861	19	18	2	2	NUM
admet-2861	19	19	important	important	ADJ
admet-2861	19	20	indicators	indicator	NOUN
admet-2861	19	21	of	of	ADP
admet-2861	19	22	the	the	DET
admet-2861	19	23	medicine	medicine	NOUN
admet-2861	19	24	's	's	PART
admet-2861	19	25	quality	quality	NOUN
admet-2861	19	26	and	and	CCONJ
admet-2861	19	27	effectiveness	effectiveness	NOUN
admet-2861	19	28	.	.	PUNCT
admet-2861	20	1	the	the	DET
admet-2861	20	2	list	list	NOUN
admet-2861	20	3	of	of	ADP
admet-2861	20	4	mandatory	mandatory	ADJ
admet-2861	20	5	quality	quality	NOUN
admet-2861	20	6	parameters	parameter	NOUN
admet-2861	20	7	for	for	ADP
admet-2861	20	8	testing	testing	NOUN
admet-2861	20	9	inhalation	inhalation	NOUN
admet-2861	20	10	products	product	NOUN
admet-2861	20	11	is	be	AUX
admet-2861	20	12	given	give	VERB
admet-2861	20	13	in	in	ADP
admet-2861	20	14	the	the	DET
admet-2861	20	15	guide	guide	NOUN
admet-2861	20	16	for	for	ADP
admet-2861	20	17	pharmaceutical	pharmaceutical	ADJ
admet-2861	20	18	quality	quality	NOUN
admet-2861	20	19	of	of	ADP
admet-2861	20	20	inhalation	inhalation	NOUN
admet-2861	20	21	and	and	CCONJ
admet-2861	20	22	nasal	nasal	ADJ
admet-2861	20	23	preparations	preparation	NOUN
admet-2861	20	24	issued	issue	VERB
admet-2861	20	25	by	by	ADP
admet-2861	20	26	the	the	DET
admet-2861	20	27	european	european	PROPN
admet-2861	20	28	medicines	medicines	PROPN
admet-2861	20	29	agency	agency	NOUN
admet-2861	20	30	(	(	PUNCT
admet-2861	20	31	ema	ema	PROPN
admet-2861	20	32	)	)	PUNCT
admet-2861	21	1	[	[	X
admet-2861	21	2	1	1	NUM
admet-2861	21	3	]	]	PUNCT
admet-2861	21	4	.	.	PUNCT
admet-2861	22	1	two	two	NUM
admet-2861	22	2	tests	test	NOUN
admet-2861	22	3	specific	specific	ADJ
admet-2861	22	4	to	to	ADP
admet-2861	22	5	inhalation	inhalation	NOUN
admet-2861	22	6	products	product	NOUN
admet-2861	22	7	that	that	PRON
admet-2861	22	8	form	form	VERB
admet-2861	22	9	the	the	DET
admet-2861	22	10	backbone	backbone	NOUN
admet-2861	22	11	of	of	ADP
admet-2861	22	12	their	their	PRON
admet-2861	22	13	quality	quality	NOUN
admet-2861	22	14	control	control	NOUN
admet-2861	22	15	are	be	AUX
admet-2861	22	16	uniformity	uniformity	NOUN
admet-2861	22	17	of	of	ADP
admet-2861	22	18	delivered	deliver	VERB
admet-2861	22	19	dose	dose	PROPN
admet-2861	22	20	(	(	PUNCT
admet-2861	22	21	udd	udd	PROPN
admet-2861	22	22	)	)	PUNCT
admet-2861	22	23	and	and	CCONJ
admet-2861	22	24	aerodynamic	aerodynamic	ADJ
admet-2861	22	25	assessment	assessment	NOUN
admet-2861	22	26	of	of	ADP
admet-2861	22	27	fine	fine	ADJ
admet-2861	22	28	particles	particle	NOUN
admet-2861	22	29	(	(	PUNCT
admet-2861	22	30	aafp	aafp	NOUN
admet-2861	22	31	)	)	PUNCT
admet-2861	23	1	[	[	X
admet-2861	23	2	2	2	NUM
admet-2861	23	3	]	]	PUNCT
admet-2861	23	4	.	.	PUNCT
admet-2861	24	1	since	since	SCONJ
admet-2861	24	2	preparations	preparation	NOUN
admet-2861	24	3	for	for	ADP
admet-2861	24	4	inhalation	inhalation	NOUN
admet-2861	24	5	are	be	AUX
admet-2861	24	6	combination	combination	NOUN
admet-2861	24	7	products	product	NOUN
admet-2861	24	8	,	,	PUNCT
admet-2861	24	9	these	these	DET
admet-2861	24	10	tests	test	NOUN
admet-2861	24	11	examine	examine	VERB
admet-2861	24	12	the	the	DET
admet-2861	24	13	relationship	relationship	NOUN
admet-2861	24	14	and	and	CCONJ
admet-2861	24	15	functionality	functionality	NOUN
admet-2861	24	16	of	of	ADP
admet-2861	24	17	the	the	DET
admet-2861	24	18	medicinal	medicinal	ADJ
admet-2861	24	19	preparation	preparation	NOUN
admet-2861	24	20	as	as	ADV
admet-2861	24	21	well	well	ADV
admet-2861	24	22	as	as	ADP
admet-2861	24	23	the	the	DET
admet-2861	24	24	delivery	delivery	NOUN
admet-2861	24	25	device	device	NOUN
admet-2861	24	26	.	.	PUNCT
admet-2861	25	1	udd	udd	PROPN
admet-2861	25	2	is	be	AUX
admet-2861	25	3	a	a	DET
admet-2861	25	4	test	test	NOUN
admet-2861	25	5	that	that	PRON
admet-2861	25	6	measures	measure	VERB
admet-2861	25	7	the	the	DET
admet-2861	25	8	amount	amount	NOUN
admet-2861	25	9	of	of	ADP
admet-2861	25	10	active	active	ADJ
admet-2861	25	11	substance	substance	NOUN
admet-2861	25	12	released	release	VERB
admet-2861	25	13	from	from	ADP
admet-2861	25	14	the	the	DET
admet-2861	25	15	inhaler	inhaler	NOUN
admet-2861	25	16	during	during	ADP
admet-2861	25	17	activation	activation	NOUN
admet-2861	25	18	or	or	CCONJ
admet-2861	25	19	inhalation	inhalation	NOUN
admet-2861	25	20	.	.	PUNCT
admet-2861	26	1	aafp	aafp	PROPN
admet-2861	26	2	examines	examine	VERB
admet-2861	26	3	the	the	DET
admet-2861	26	4	distribution	distribution	NOUN
admet-2861	26	5	of	of	ADP
admet-2861	26	6	aerosol	aerosol	NOUN
admet-2861	26	7	particles	particle	NOUN
admet-2861	26	8	based	base	VERB
admet-2861	26	9	on	on	ADP
admet-2861	26	10	their	their	PRON
admet-2861	26	11	aerodynamic	aerodynamic	ADJ
admet-2861	26	12	diameter	diameter	NOUN
admet-2861	26	13	.	.	PUNCT
admet-2861	27	1	tests	test	NOUN
admet-2861	27	2	and	and	CCONJ
admet-2861	27	3	procedures	procedure	NOUN
admet-2861	27	4	are	be	AUX
admet-2861	27	5	described	describe	VERB
admet-2861	27	6	in	in	ADP
admet-2861	27	7	the	the	DET
admet-2861	27	8	corresponding	corresponding	ADJ
admet-2861	27	9	monographs	monograph	NOUN
admet-2861	27	10	of	of	ADP
admet-2861	27	11	the	the	DET
admet-2861	27	12	european	european	ADJ
admet-2861	27	13	pharmacopoeia	pharmacopoeia	NOUN
admet-2861	27	14	[	[	X
admet-2861	27	15	2	2	NUM
admet-2861	27	16	]	]	PUNCT
admet-2861	27	17	.	.	PUNCT
admet-2861	28	1	according	accord	VERB
admet-2861	28	2	to	to	ADP
admet-2861	28	3	the	the	DET
admet-2861	28	4	current	current	ADJ
admet-2861	28	5	ema	ema	PROPN
admet-2861	28	6	guideline	guideline	NOUN
admet-2861	28	7	[	[	X
admet-2861	28	8	1	1	NUM
admet-2861	28	9	]	]	PUNCT
admet-2861	28	10	,	,	PUNCT
admet-2861	28	11	there	there	PRON
admet-2861	28	12	is	be	VERB
admet-2861	28	13	no	no	DET
admet-2861	28	14	requirement	requirement	NOUN
admet-2861	28	15	or	or	CCONJ
admet-2861	28	16	mention	mention	NOUN
admet-2861	28	17	of	of	ADP
admet-2861	28	18	a	a	DET
admet-2861	28	19	dissolution	dissolution	NOUN
admet-2861	28	20	test	test	NOUN
admet-2861	28	21	for	for	ADP
admet-2861	28	22	preparations	preparation	NOUN
admet-2861	28	23	intended	intend	VERB
admet-2861	28	24	for	for	ADP
admet-2861	28	25	inhalation	inhalation	NOUN
admet-2861	28	26	.	.	PUNCT
admet-2861	29	1	the	the	DET
admet-2861	29	2	dissolution	dissolution	NOUN
admet-2861	29	3	test	test	NOUN
admet-2861	29	4	is	be	AUX
admet-2861	29	5	introduced	introduce	VERB
admet-2861	29	6	in	in	ADP
admet-2861	29	7	the	the	DET
admet-2861	29	8	draft	draft	NOUN
admet-2861	29	9	ema	ema	PROPN
admet-2861	29	10	guideline	guideline	NOUN
admet-2861	29	11	for	for	ADP
admet-2861	29	12	the	the	DET
admet-2861	29	13	quality	quality	NOUN
admet-2861	29	14	of	of	ADP
admet-2861	29	15	inhalation	inhalation	NOUN
admet-2861	29	16	products	product	NOUN
admet-2861	29	17	[	[	X
admet-2861	29	18	3	3	NUM
admet-2861	29	19	]	]	PUNCT
admet-2861	29	20	,	,	PUNCT
admet-2861	29	21	where	where	SCONJ
admet-2861	29	22	it	it	PRON
admet-2861	29	23	is	be	AUX
admet-2861	29	24	stated	state	VERB
admet-2861	29	25	that	that	SCONJ
admet-2861	29	26	“	"	PUNCT
admet-2861	29	27	development	development	NOUN
admet-2861	29	28	and	and	CCONJ
admet-2861	29	29	characterization	characterization	NOUN
admet-2861	29	30	studies	study	NOUN
admet-2861	29	31	based	base	VERB
admet-2861	29	32	on	on	ADP
admet-2861	29	33	dissolution	dissolution	NOUN
admet-2861	29	34	testing	testing	NOUN
admet-2861	29	35	can	can	AUX
admet-2861	29	36	be	be	AUX
admet-2861	29	37	provided	provide	VERB
admet-2861	29	38	as	as	ADP
admet-2861	29	39	supportive	supportive	ADJ
admet-2861	29	40	information	information	NOUN
admet-2861	29	41	”	"	PUNCT
admet-2861	29	42	for	for	ADP
admet-2861	29	43	the	the	DET
admet-2861	29	44	pharmaceutical	pharmaceutical	ADJ
admet-2861	29	45	development	development	NOUN
admet-2861	29	46	and	and	CCONJ
admet-2861	29	47	that	that	SCONJ
admet-2861	29	48	“	"	PUNCT
admet-2861	29	49	changes	change	NOUN
admet-2861	29	50	that	that	PRON
admet-2861	29	51	affect	affect	VERB
admet-2861	29	52	the	the	DET
admet-2861	29	53	in	in	ADV
admet-2861	29	54	vitro	vitro	X
admet-2861	29	55	apsd	apsd	VERB
admet-2861	29	56	or	or	CCONJ
admet-2861	29	57	in	in	ADP
admet-2861	29	58	vitro	vitro	X
admet-2861	29	59	dissolution	dissolution	NOUN
admet-2861	29	60	release	release	NOUN
admet-2861	29	61	characteristics	characteristic	NOUN
admet-2861	29	62	of	of	ADP
admet-2861	29	63	the	the	DET
admet-2861	29	64	finished	finish	VERB
admet-2861	29	65	product	product	NOUN
admet-2861	29	66	may	may	AUX
admet-2861	29	67	be	be	AUX
admet-2861	29	68	considered	consider	VERB
admet-2861	29	69	to	to	PART
admet-2861	29	70	have	have	VERB
admet-2861	29	71	a	a	DET
admet-2861	29	72	significant	significant	ADJ
admet-2861	29	73	impact	impact	NOUN
admet-2861	29	74	”	"	PUNCT
admet-2861	29	75	.	.	PUNCT
admet-2861	30	1	a	a	DET
admet-2861	30	2	similar	similar	ADJ
admet-2861	30	3	approach	approach	NOUN
admet-2861	30	4	is	be	AUX
admet-2861	30	5	suggested	suggest	VERB
admet-2861	30	6	in	in	ADP
admet-2861	30	7	the	the	DET
admet-2861	30	8	guidelines	guideline	NOUN
admet-2861	30	9	for	for	ADP
admet-2861	30	10	specific	specific	ADJ
admet-2861	30	11	drug	drug	NOUN
admet-2861	30	12	products	product	NOUN
admet-2861	30	13	issued	issue	VERB
admet-2861	30	14	by	by	ADP
admet-2861	30	15	the	the	DET
admet-2861	30	16	fda	fda	PROPN
admet-2861	30	17	.	.	PUNCT
admet-2861	31	1	however	however	ADV
admet-2861	31	2	,	,	PUNCT
admet-2861	31	3	in	in	ADP
admet-2861	31	4	the	the	DET
admet-2861	31	5	guidelines	guideline	NOUN
admet-2861	31	6	currently	currently	ADV
admet-2861	31	7	in	in	ADP
admet-2861	31	8	effect	effect	NOUN
admet-2861	31	9	,	,	PUNCT
admet-2861	31	10	there	there	PRON
admet-2861	31	11	are	be	VERB
admet-2861	31	12	no	no	DET
admet-2861	31	13	requirements	requirement	NOUN
admet-2861	31	14	for	for	ADP
admet-2861	31	15	conducting	conduct	VERB
admet-2861	31	16	the	the	DET
admet-2861	31	17	test	test	NOUN
admet-2861	31	18	,	,	PUNCT
admet-2861	31	19	which	which	PRON
admet-2861	31	20	aligns	align	VERB
admet-2861	31	21	with	with	ADP
admet-2861	31	22	the	the	DET
admet-2861	31	23	conclusion	conclusion	NOUN
admet-2861	31	24	of	of	ADP
admet-2861	31	25	the	the	DET
admet-2861	31	26	2008	2008	NUM
admet-2861	31	27	ad	ad	X
admet-2861	31	28	hoc	hoc	X
admet-2861	31	29	advisory	advisory	ADJ
admet-2861	31	30	panel	panel	NOUN
admet-2861	31	31	for	for	ADP
admet-2861	31	32	the	the	DET
admet-2861	31	33	usp	usp	NOUN
admet-2861	31	34	performance	performance	NOUN
admet-2861	31	35	test	test	NOUN
admet-2861	31	36	of	of	ADP
admet-2861	31	37	inhalation	inhalation	NOUN
admet-2861	31	38	dosage	dosage	NOUN
admet-2861	31	39	forms	form	NOUN
admet-2861	31	40	[	[	X
admet-2861	31	41	4	4	NUM
admet-2861	31	42	]	]	PUNCT
admet-2861	31	43	.	.	PUNCT
admet-2861	32	1	in	in	ADP
admet-2861	32	2	2024	2024	NUM
admet-2861	32	3	,	,	PUNCT
admet-2861	32	4	the	the	DET
admet-2861	32	5	revised	revise	VERB
admet-2861	32	6	draft	draft	NOUN
admet-2861	32	7	guidance	guidance	NOUN
admet-2861	32	8	on	on	ADP
admet-2861	32	9	budesonide	budesonide	NOUN
admet-2861	32	10	and	and	CCONJ
admet-2861	32	11	formoterol	formoterol	NOUN
admet-2861	32	12	fumarate	fumarate	NOUN
admet-2861	33	1	[	[	X
admet-2861	33	2	5	5	NUM
admet-2861	33	3	]	]	PUNCT
admet-2861	33	4	and	and	CCONJ
admet-2861	33	5	draft	draft	NOUN
admet-2861	33	6	guidance	guidance	NOUN
admet-2861	33	7	on	on	ADP
admet-2861	33	8	fluticasone	fluticasone	NOUN
admet-2861	33	9	propionate	propionate	NOUN
admet-2861	33	10	[	[	X
admet-2861	33	11	6	6	NUM
admet-2861	33	12	]	]	PUNCT
admet-2861	33	13	were	be	AUX
admet-2861	33	14	published	publish	VERB
admet-2861	33	15	.	.	PUNCT
admet-2861	34	1	these	these	DET
admet-2861	34	2	guidelines	guideline	NOUN
admet-2861	34	3	require	require	VERB
admet-2861	34	4	a	a	DET
admet-2861	34	5	dissolution	dissolution	NOUN
admet-2861	34	6	test	test	NOUN
admet-2861	34	7	as	as	ADP
admet-2861	34	8	one	one	NUM
admet-2861	34	9	of	of	ADP
admet-2861	34	10	the	the	DET
admet-2861	34	11	seven	seven	NUM
admet-2861	34	12	tests	test	NOUN
admet-2861	34	13	to	to	PART
admet-2861	34	14	demonstrate	demonstrate	VERB
admet-2861	34	15	the	the	DET
admet-2861	34	16	in	in	ADP
admet-2861	34	17	vitro	vitro	X
admet-2861	34	18	equivalence	equivalence	NOUN
admet-2861	34	19	of	of	ADP
admet-2861	34	20	inhalation	inhalation	NOUN
admet-2861	34	21	products	product	NOUN
admet-2861	34	22	.	.	PUNCT
admet-2861	35	1	although	although	SCONJ
admet-2861	35	2	the	the	DET
admet-2861	35	3	draft	draft	NOUN
admet-2861	35	4	guidelines	guideline	NOUN
admet-2861	35	5	provide	provide	VERB
admet-2861	35	6	recommendations	recommendation	NOUN
admet-2861	35	7	for	for	ADP
admet-2861	35	8	selecting	select	VERB
admet-2861	35	9	the	the	DET
admet-2861	35	10	apparatus	apparatus	NOUN
admet-2861	35	11	for	for	ADP
admet-2861	35	12	conducting	conduct	VERB
admet-2861	35	13	the	the	DET
admet-2861	35	14	test	test	NOUN
admet-2861	35	15	and	and	CCONJ
admet-2861	35	16	evaluating	evaluate	VERB
admet-2861	35	17	the	the	DET
admet-2861	35	18	results	result	NOUN
admet-2861	35	19	,	,	PUNCT
admet-2861	35	20	there	there	PRON
admet-2861	35	21	is	be	VERB
admet-2861	35	22	still	still	ADV
admet-2861	35	23	no	no	DET
admet-2861	35	24	generally	generally	ADV
admet-2861	35	25	accepted	accept	VERB
admet-2861	35	26	methodology	methodology	NOUN
admet-2861	35	27	for	for	ADP
admet-2861	35	28	conducting	conduct	VERB
admet-2861	35	29	and	and	CCONJ
admet-2861	35	30	evaluating	evaluate	VERB
admet-2861	35	31	the	the	DET
admet-2861	35	32	dissolution	dissolution	NOUN
admet-2861	35	33	test	test	NOUN
admet-2861	35	34	results	result	NOUN
admet-2861	35	35	for	for	ADP
admet-2861	35	36	inhalation	inhalation	NOUN
admet-2861	35	37	products	product	NOUN
admet-2861	35	38	[	[	X
admet-2861	35	39	7	7	NUM
admet-2861	35	40	-	-	SYM
admet-2861	35	41	9	9	NUM
admet-2861	35	42	]	]	PUNCT
admet-2861	35	43	.	.	PUNCT
admet-2861	36	1	numerous	numerous	ADJ
admet-2861	36	2	authors	author	NOUN
admet-2861	36	3	and	and	CCONJ
admet-2861	36	4	research	research	NOUN
admet-2861	36	5	groups	group	NOUN
admet-2861	36	6	have	have	AUX
admet-2861	36	7	developed	develop	VERB
admet-2861	36	8	models	model	NOUN
admet-2861	36	9	for	for	ADP
admet-2861	36	10	testing	test	VERB
admet-2861	36	11	the	the	DET
admet-2861	36	12	release	release	NOUN
admet-2861	36	13	rate	rate	NOUN
admet-2861	36	14	of	of	ADP
admet-2861	36	15	medicinal	medicinal	ADJ
admet-2861	36	16	substances	substance	NOUN
admet-2861	36	17	from	from	ADP
admet-2861	36	18	inhalation	inhalation	NOUN
admet-2861	36	19	preparations	preparation	NOUN
admet-2861	36	20	.	.	PUNCT
admet-2861	37	1	the	the	DET
admet-2861	37	2	applied	apply	VERB
admet-2861	37	3	approaches	approach	NOUN
admet-2861	37	4	can	can	AUX
admet-2861	37	5	,	,	PUNCT
admet-2861	37	6	in	in	ADP
admet-2861	37	7	general	general	ADJ
admet-2861	37	8	,	,	PUNCT
admet-2861	37	9	be	be	AUX
admet-2861	37	10	described	describe	VERB
admet-2861	37	11	as	as	ADP
admet-2861	37	12	those	those	PRON
admet-2861	37	13	in	in	ADP
admet-2861	37	14	which	which	PRON
admet-2861	37	15	the	the	DET
admet-2861	37	16	dissolution	dissolution	NOUN
admet-2861	37	17	of	of	ADP
admet-2861	37	18	the	the	DET
admet-2861	37	19	entire	entire	ADJ
admet-2861	37	20	preparation	preparation	NOUN
admet-2861	37	21	is	be	AUX
admet-2861	37	22	tested	test	VERB
admet-2861	37	23	and	and	CCONJ
admet-2861	37	24	those	those	PRON
admet-2861	37	25	in	in	ADP
admet-2861	37	26	which	which	PRON
admet-2861	37	27	the	the	DET
admet-2861	37	28	dissolution	dissolution	NOUN
admet-2861	37	29	of	of	ADP
admet-2861	37	30	particles	particle	NOUN
admet-2861	37	31	previously	previously	ADV
admet-2861	37	32	classified	classify	VERB
admet-2861	37	33	based	base	VERB
admet-2861	37	34	on	on	ADP
admet-2861	37	35	their	their	PRON
admet-2861	37	36	aerodynamic	aerodynamic	ADJ
admet-2861	37	37	diameter	diameter	NOUN
admet-2861	37	38	is	be	AUX
admet-2861	37	39	tested	test	VERB
admet-2861	37	40	.	.	PUNCT
admet-2861	38	1	both	both	DET
admet-2861	38	2	approaches	approach	NOUN
admet-2861	38	3	have	have	VERB
admet-2861	38	4	advantages	advantage	NOUN
admet-2861	38	5	and	and	CCONJ
admet-2861	38	6	disadvantages	disadvantage	NOUN
admet-2861	38	7	.	.	PUNCT
admet-2861	39	1	another	another	DET
admet-2861	39	2	way	way	NOUN
admet-2861	39	3	to	to	PART
admet-2861	39	4	differentiate	differentiate	VERB
admet-2861	39	5	the	the	DET
admet-2861	39	6	methods	method	NOUN
admet-2861	39	7	of	of	ADP
admet-2861	39	8	testing	test	VERB
admet-2861	39	9	drug	drug	NOUN
admet-2861	39	10	dissolution	dissolution	NOUN
admet-2861	39	11	rates	rate	NOUN
admet-2861	39	12	from	from	ADP
admet-2861	39	13	inhalation	inhalation	NOUN
admet-2861	39	14	products	product	NOUN
admet-2861	39	15	is	be	AUX
admet-2861	39	16	based	base	VERB
admet-2861	39	17	on	on	ADP
admet-2861	39	18	the	the	DET
admet-2861	39	19	technical	technical	ADJ
admet-2861	39	20	performance	performance	NOUN
admet-2861	39	21	of	of	ADP
admet-2861	39	22	the	the	DET
admet-2861	39	23	apparatus	apparatus	NOUN
admet-2861	39	24	used	use	VERB
admet-2861	39	25	.	.	PUNCT
admet-2861	40	1	the	the	DET
admet-2861	40	2	described	describe	VERB
admet-2861	40	3	procedures	procedure	NOUN
admet-2861	40	4	are	be	AUX
admet-2861	40	5	based	base	VERB
admet-2861	40	6	on	on	ADP
admet-2861	40	7	the	the	DET
admet-2861	40	8	use	use	NOUN
admet-2861	40	9	of	of	ADP
admet-2861	40	10	diffusion	diffusion	NOUN
admet-2861	40	11	cells	cell	NOUN
admet-2861	40	12	[	[	X
admet-2861	40	13	10	10	NUM
admet-2861	40	14	-	-	SYM
admet-2861	40	15	13	13	NUM
admet-2861	40	16	]	]	PUNCT
admet-2861	40	17	,	,	PUNCT
admet-2861	40	18	transwell	transwell	NOUN
admet-2861	40	19	systems	system	NOUN
admet-2861	41	1	[	[	X
admet-2861	41	2	14	14	NUM
admet-2861	41	3	-	-	SYM
admet-2861	41	4	16	16	NUM
admet-2861	41	5	]	]	PUNCT
admet-2861	41	6	,	,	PUNCT
admet-2861	41	7	flow	flow	NOUN
admet-2861	41	8	cells	cell	NOUN
admet-2861	41	9	[	[	X
admet-2861	41	10	17	17	NUM
admet-2861	41	11	-	-	SYM
admet-2861	41	12	19	19	NUM
admet-2861	41	13	]	]	PUNCT
admet-2861	41	14	,	,	PUNCT
admet-2861	41	15	modified	modify	VERB
admet-2861	41	16	usp	usp	NOUN
admet-2861	41	17	apparatuses	apparatus	NOUN
admet-2861	41	18	2	2	NUM
admet-2861	41	19	and	and	CCONJ
admet-2861	41	20	5	5	NUM
admet-2861	41	21	[	[	NOUN
admet-2861	41	22	9,20	9,20	X
admet-2861	41	23	]	]	X
admet-2861	41	24	,	,	PUNCT
admet-2861	41	25	and	and	CCONJ
admet-2861	41	26	proprietary	proprietary	ADJ
admet-2861	41	27	systems	system	NOUN
admet-2861	41	28	based	base	VERB
admet-2861	41	29	on	on	ADP
admet-2861	41	30	diffusion	diffusion	NOUN
admet-2861	41	31	cells	cell	NOUN
admet-2861	41	32	[	[	X
admet-2861	41	33	21	21	NUM
admet-2861	41	34	-	-	SYM
admet-2861	41	35	23	23	NUM
admet-2861	41	36	]	]	PUNCT
admet-2861	41	37	.	.	PUNCT
admet-2861	42	1	of	of	ADP
admet-2861	42	2	the	the	DET
admet-2861	42	3	mentioned	mention	VERB
admet-2861	42	4	procedures	procedure	NOUN
admet-2861	42	5	,	,	PUNCT
admet-2861	42	6	only	only	ADV
admet-2861	42	7	a	a	DET
admet-2861	42	8	small	small	ADJ
admet-2861	42	9	number	number	NOUN
admet-2861	42	10	have	have	AUX
admet-2861	42	11	been	be	AUX
admet-2861	42	12	reported	report	VERB
admet-2861	42	13	to	to	PART
admet-2861	42	14	be	be	AUX
admet-2861	42	15	able	able	ADJ
admet-2861	42	16	to	to	PART
admet-2861	42	17	detect	detect	VERB
admet-2861	42	18	differences	difference	NOUN
admet-2861	42	19	in	in	ADP
admet-2861	42	20	formulations	formulation	NOUN
admet-2861	42	21	with	with	ADP
admet-2861	42	22	the	the	DET
admet-2861	42	23	same	same	ADJ
admet-2861	42	24	active	active	ADJ
admet-2861	42	25	substance	substance	NOUN
admet-2861	42	26	[	[	X
admet-2861	42	27	12,16,20	12,16,20	NUM
admet-2861	42	28	]	]	PUNCT
admet-2861	42	29	.	.	PUNCT
admet-2861	43	1	a	a	DET
admet-2861	43	2	more	more	ADV
admet-2861	43	3	comprehensive	comprehensive	ADJ
admet-2861	43	4	overview	overview	NOUN
admet-2861	43	5	of	of	ADP
admet-2861	43	6	the	the	DET
admet-2861	43	7	published	publish	VERB
admet-2861	43	8	literature	literature	NOUN
admet-2861	43	9	can	can	AUX
admet-2861	43	10	be	be	AUX
admet-2861	43	11	found	find	VERB
admet-2861	43	12	in	in	ADP
admet-2861	43	13	the	the	DET
admet-2861	43	14	relevant	relevant	ADJ
admet-2861	43	15	literature	literature	NOUN
admet-2861	43	16	[	[	X
admet-2861	43	17	7,24	7,24	NUM
admet-2861	43	18	-	-	SYM
admet-2861	43	19	26	26	NUM
admet-2861	43	20	]	]	PUNCT
admet-2861	43	21	.	.	PUNCT
admet-2861	44	1	the	the	DET
admet-2861	44	2	aim	aim	NOUN
admet-2861	44	3	of	of	ADP
admet-2861	44	4	the	the	DET
admet-2861	44	5	present	present	ADJ
admet-2861	44	6	study	study	NOUN
admet-2861	44	7	was	be	AUX
admet-2861	44	8	to	to	PART
admet-2861	44	9	explore	explore	VERB
admet-2861	44	10	the	the	DET
admet-2861	44	11	discriminatory	discriminatory	ADJ
admet-2861	44	12	ability	ability	NOUN
admet-2861	44	13	and	and	CCONJ
admet-2861	44	14	in	in	ADP
admet-2861	44	15	vivo	vivo	ADJ
admet-2861	44	16	predictability	predictability	NOUN
admet-2861	44	17	of	of	ADP
admet-2861	44	18	the	the	DET
admet-2861	44	19	newly	newly	ADV
admet-2861	44	20	developed	develop	VERB
admet-2861	44	21	dissolution	dissolution	NOUN
admet-2861	44	22	assembly	assembly	NOUN
admet-2861	44	23	[	[	X
admet-2861	44	24	27	27	NUM
admet-2861	44	25	]	]	PUNCT
admet-2861	44	26	.	.	PUNCT
admet-2861	45	1	seven	seven	NUM
admet-2861	45	2	inhalation	inhalation	NOUN
admet-2861	45	3	products	product	NOUN
admet-2861	45	4	with	with	ADP
admet-2861	45	5	marketing	marketing	NOUN
admet-2861	45	6	authorization	authorization	NOUN
admet-2861	45	7	containing	contain	VERB
admet-2861	45	8	either	either	CCONJ
admet-2861	45	9	high	high	ADJ
admet-2861	45	10	or	or	CCONJ
admet-2861	45	11	low	low	ADJ
admet-2861	45	12	solubility	solubility	NOUN
admet-2861	45	13	model	model	NOUN
admet-2861	45	14	drugs	drug	NOUN
admet-2861	45	15	have	have	AUX
admet-2861	45	16	been	be	AUX
admet-2861	45	17	investigated	investigate	VERB
admet-2861	45	18	.	.	PUNCT
admet-2861	46	1	experimental	experimental	ADJ
admet-2861	46	2	materials	material	NOUN
admet-2861	46	3	beclomethasone	beclomethasone	NOUN
admet-2861	46	4	dipropionate	dipropionate	NOUN
admet-2861	46	5	(	(	PUNCT
admet-2861	46	6	bdp	bdp	PROPN
admet-2861	46	7	)	)	PUNCT
admet-2861	46	8	and	and	CCONJ
admet-2861	46	9	salmeterol	salmeterol	PROPN
admet-2861	46	10	xinafoate	xinafoate	VERB
admet-2861	46	11	(	(	PUNCT
admet-2861	46	12	sx	sx	NOUN
admet-2861	46	13	)	)	PUNCT
admet-2861	46	14	were	be	AUX
admet-2861	46	15	chosen	choose	VERB
admet-2861	46	16	as	as	ADP
admet-2861	46	17	model	model	NOUN
admet-2861	46	18	substances	substance	NOUN
admet-2861	46	19	,	,	PUNCT
admet-2861	46	20	and	and	CCONJ
admet-2861	46	21	pharmacopoeial	pharmacopoeial	ADJ
admet-2861	46	22	reference	reference	NOUN
admet-2861	46	23	standards	standard	NOUN
admet-2861	46	24	(	(	PUNCT
admet-2861	46	25	european	european	ADJ
admet-2861	46	26	pharmacopoeia	pharmacopoeia	NOUN
admet-2861	46	27	reference	reference	NOUN
admet-2861	46	28	standards	standard	NOUN
admet-2861	46	29	)	)	PUNCT
admet-2861	46	30	were	be	AUX
admet-2861	46	31	used	use	VERB
admet-2861	46	32	for	for	ADP
admet-2861	46	33	analysis	analysis	NOUN
admet-2861	46	34	.	.	PUNCT
admet-2861	47	1	seven	seven	NUM
admet-2861	47	2	pressurized	pressurize	VERB
admet-2861	47	3	metered	meter	VERB
admet-2861	47	4	dose	dose	NOUN
admet-2861	47	5	inhalers	inhaler	NOUN
admet-2861	47	6	(	(	PUNCT
admet-2861	47	7	mdi	mdi	PROPN
admet-2861	47	8	)	)	PUNCT
admet-2861	47	9	products	product	NOUN
admet-2861	47	10	containing	contain	VERB
admet-2861	47	11	bdp	bdp	PROPN
admet-2861	47	12	(	(	PUNCT
admet-2861	47	13	3	3	NUM
admet-2861	47	14	preparations	preparation	NOUN
admet-2861	47	15	marked	mark	VERB
admet-2861	47	16	b1	b1	NOUN
admet-2861	47	17	,	,	PUNCT
admet-2861	47	18	b2	b2	NOUN
admet-2861	47	19	and	and	CCONJ
admet-2861	47	20	b3	b3	NOUN
admet-2861	47	21	)	)	PUNCT
admet-2861	47	22	and	and	CCONJ
admet-2861	47	23	sx	sx	PROPN
admet-2861	47	24	(	(	PUNCT
admet-2861	47	25	4	4	NUM
admet-2861	47	26	preparations	preparation	NOUN
admet-2861	47	27	marked	mark	VERB
admet-2861	47	28	s1	s1	NOUN
admet-2861	47	29	,	,	PUNCT
admet-2861	47	30	s2	s2	PROPN
admet-2861	47	31	,	,	PUNCT
admet-2861	47	32	s3	s3	PROPN
admet-2861	47	33	and	and	CCONJ
admet-2861	47	34	s4	s4	PROPN
admet-2861	47	35	)	)	PUNCT
admet-2861	47	36	were	be	AUX
admet-2861	47	37	tested	test	VERB
admet-2861	47	38	.	.	PUNCT
admet-2861	48	1	inhalers	inhaler	NOUN
admet-2861	48	2	were	be	AUX
admet-2861	48	3	purchased	purchase	VERB
admet-2861	48	4	on	on	ADP
admet-2861	48	5	the	the	DET
admet-2861	48	6	markets	market	NOUN
admet-2861	48	7	of	of	ADP
admet-2861	48	8	bosnia	bosnia	PROPN
admet-2861	48	9	and	and	CCONJ
admet-2861	48	10	herzegovina	herzegovina	PROPN
admet-2861	48	11	and	and	CCONJ
admet-2861	48	12	germany	germany	PROPN
admet-2861	48	13	.	.	PUNCT
admet-2861	49	1	all	all	DET
admet-2861	49	2	used	use	VERB
admet-2861	49	3	chemicals	chemical	NOUN
admet-2861	49	4	were	be	AUX
admet-2861	49	5	pa	pa	PROPN
admet-2861	49	6	grade	grade	NOUN
admet-2861	49	7	or	or	CCONJ
admet-2861	49	8	better	well	ADJ
admet-2861	49	9	.	.	PUNCT
admet-2861	50	1	admet	admet	PROPN
admet-2861	50	2	&	&	CCONJ
admet-2861	50	3	dmpk	dmpk	PROPN
admet-2861	50	4	13	13	NUM
admet-2861	50	5	(	(	PUNCT
admet-2861	50	6	)	)	PUNCT
admet-2861	50	7	(	(	PUNCT
admet-2861	50	8	2025	2025	NUM
admet-2861	50	9	)	)	PUNCT
admet-2861	50	10	2861	2861	NUM
admet-2861	50	11	development	development	NOUN
admet-2861	50	12	of	of	ADP
admet-2861	50	13	a	a	DET
admet-2861	50	14	biorelevant	biorelevant	ADJ
admet-2861	50	15	dissolution	dissolution	NOUN
admet-2861	50	16	method	method	NOUN
admet-2861	50	17	for	for	ADP
admet-2861	50	18	inhalation	inhalation	NOUN
admet-2861	50	19	products	product	NOUN
admet-2861	50	20	doi	doi	NOUN
admet-2861	50	21	:	:	PUNCT
admet-2861	50	22	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	50	23	3	3	NUM
admet-2861	50	24	aerodynamic	aerodynamic	ADJ
admet-2861	50	25	assessment	assessment	NOUN
admet-2861	50	26	of	of	ADP
admet-2861	50	27	fine	fine	ADJ
admet-2861	50	28	particles	particle	NOUN
admet-2861	50	29	aerodynamic	aerodynamic	ADJ
admet-2861	50	30	assessment	assessment	NOUN
admet-2861	50	31	of	of	ADP
admet-2861	50	32	fine	fine	ADJ
admet-2861	50	33	particles	particle	NOUN
admet-2861	50	34	was	be	AUX
admet-2861	50	35	determined	determine	VERB
admet-2861	50	36	in	in	ADP
admet-2861	50	37	accordance	accordance	NOUN
admet-2861	50	38	with	with	ADP
admet-2861	50	39	ph	ph	PROPN
admet-2861	50	40	.	.	PROPN
admet-2861	50	41	eur	eur	PROPN
admet-2861	50	42	.	.	PUNCT
admet-2861	51	1	monograph	monograph	PROPN
admet-2861	51	2	2.9.18	2.9.18	NUM
admet-2861	51	3	using	use	VERB
admet-2861	51	4	the	the	DET
admet-2861	51	5	next	next	ADJ
admet-2861	51	6	generation	generation	NOUN
admet-2861	51	7	impactor	impactor	NOUN
admet-2861	51	8	(	(	PUNCT
admet-2861	51	9	ngi	ngi	PROPN
admet-2861	51	10	)	)	PUNCT
admet-2861	51	11	(	(	PUNCT
admet-2861	51	12	copley	copley	NOUN
admet-2861	51	13	scientific	scientific	ADJ
admet-2861	51	14	limited	limit	VERB
admet-2861	51	15	,	,	PUNCT
admet-2861	51	16	uk	uk	PROPN
admet-2861	51	17	)	)	PUNCT
admet-2861	51	18	.	.	PUNCT
admet-2861	52	1	fine	fine	ADJ
admet-2861	52	2	particle	particle	NOUN
admet-2861	52	3	fraction	fraction	NOUN
admet-2861	52	4	(	(	PUNCT
admet-2861	52	5	fpf	fpf	NOUN
admet-2861	52	6	)	)	PUNCT
admet-2861	52	7	,	,	PUNCT
admet-2861	52	8	mass	mass	ADJ
admet-2861	52	9	median	median	ADJ
admet-2861	52	10	aerodynamic	aerodynamic	ADJ
admet-2861	52	11	diameter	diameter	NOUN
admet-2861	52	12	(	(	PUNCT
admet-2861	52	13	mmad	mmad	NOUN
admet-2861	52	14	)	)	PUNCT
admet-2861	52	15	,	,	PUNCT
admet-2861	52	16	and	and	CCONJ
admet-2861	52	17	geometric	geometric	ADJ
admet-2861	52	18	standard	standard	ADJ
admet-2861	52	19	deviation	deviation	NOUN
admet-2861	52	20	(	(	PUNCT
admet-2861	52	21	gsd	gsd	NOUN
admet-2861	52	22	)	)	PUNCT
admet-2861	52	23	were	be	AUX
admet-2861	52	24	calculated	calculate	VERB
admet-2861	52	25	using	use	VERB
admet-2861	52	26	the	the	DET
admet-2861	52	27	citdas	citda	NOUN
admet-2861	52	28	v.	v.	ADP
admet-2861	52	29	3.10	3.10	NUM
admet-2861	52	30	software	software	NOUN
admet-2861	52	31	(	(	PUNCT
admet-2861	52	32	copley	copley	NOUN
admet-2861	52	33	scientific	scientific	PROPN
admet-2861	52	34	,	,	PUNCT
admet-2861	52	35	nottingham	nottingham	PROPN
admet-2861	52	36	,	,	PUNCT
admet-2861	52	37	uk	uk	PROPN
admet-2861	52	38	,	,	PUNCT
admet-2861	52	39	https://pv-systems.pl/en/products/copleyscientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	https://pv-systems.pl/en/products/copleyscientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	PROPN
admet-2861	52	40	)	)	PUNCT
admet-2861	52	41	.	.	PUNCT
admet-2861	53	1	solubility	solubility	NOUN
admet-2861	53	2	determination	determination	NOUN
admet-2861	53	3	the	the	DET
admet-2861	53	4	excess	excess	ADJ
admet-2861	53	5	amount	amount	NOUN
admet-2861	53	6	(	(	PUNCT
admet-2861	53	7	around	around	ADV
admet-2861	53	8	100	100	NUM
admet-2861	53	9	mg	mg	NOUN
admet-2861	53	10	)	)	PUNCT
admet-2861	53	11	of	of	ADP
admet-2861	53	12	the	the	DET
admet-2861	53	13	investigated	investigate	VERB
admet-2861	53	14	active	active	ADJ
admet-2861	53	15	substances	substance	NOUN
admet-2861	53	16	was	be	AUX
admet-2861	53	17	placed	place	VERB
admet-2861	53	18	in	in	ADP
admet-2861	53	19	a	a	DET
admet-2861	53	20	2	2	NUM
admet-2861	53	21	ml	ml	NOUN
admet-2861	53	22	glass	glass	NOUN
admet-2861	53	23	vials	vial	NOUN
admet-2861	53	24	,	,	PUNCT
admet-2861	53	25	then	then	ADV
admet-2861	53	26	2	2	NUM
admet-2861	53	27	ml	ml	NOUN
admet-2861	53	28	of	of	ADP
admet-2861	53	29	the	the	DET
admet-2861	53	30	test	test	NOUN
admet-2861	53	31	medium	medium	NOUN
admet-2861	53	32	was	be	AUX
admet-2861	53	33	added	add	VERB
admet-2861	53	34	,	,	PUNCT
admet-2861	53	35	and	and	CCONJ
admet-2861	53	36	the	the	DET
admet-2861	53	37	mixture	mixture	NOUN
admet-2861	53	38	was	be	AUX
admet-2861	53	39	thermostated	thermostat	VERB
admet-2861	53	40	at	at	ADP
admet-2861	53	41	37	37	NUM
admet-2861	53	42	°	°	ADP
admet-2861	53	43	c	c	NOUN
admet-2861	53	44	with	with	ADP
admet-2861	53	45	constant	constant	ADJ
admet-2861	53	46	stirring	stirring	NOUN
admet-2861	53	47	,	,	PUNCT
admet-2861	53	48	using	use	VERB
admet-2861	53	49	a	a	DET
admet-2861	53	50	reacti	reacti	VERB
admet-2861	53	51	-	-	PUNCT
admet-2861	53	52	thermtm	thermtm	ADJ
admet-2861	53	53	heating	heating	NOUN
admet-2861	53	54	/	/	SYM
admet-2861	53	55	stirring	stir	VERB
admet-2861	53	56	module	module	NOUN
admet-2861	53	57	(	(	PUNCT
admet-2861	53	58	thermo	thermo	NOUN
admet-2861	53	59	fisher	fisher	PROPN
admet-2861	53	60	scientific	scientific	PROPN
admet-2861	53	61	inc	inc	PROPN
admet-2861	53	62	.	.	PROPN
admet-2861	53	63	,	,	PUNCT
admet-2861	53	64	usa	usa	PROPN
admet-2861	53	65	)	)	PUNCT
admet-2861	53	66	for	for	ADP
admet-2861	53	67	a	a	DET
admet-2861	53	68	minimum	minimum	NOUN
admet-2861	53	69	of	of	ADP
admet-2861	53	70	16	16	NUM
admet-2861	53	71	hours	hour	NOUN
admet-2861	53	72	.	.	PUNCT
admet-2861	54	1	after	after	ADP
admet-2861	54	2	the	the	DET
admet-2861	54	3	predetermined	predetermined	ADJ
admet-2861	54	4	time	time	NOUN
admet-2861	54	5	,	,	PUNCT
admet-2861	54	6	the	the	DET
admet-2861	54	7	suspension	suspension	NOUN
admet-2861	54	8	was	be	AUX
admet-2861	54	9	centrifuged	centrifuge	VERB
admet-2861	54	10	at	at	ADP
admet-2861	54	11	14,000	14,000	NUM
admet-2861	54	12	rpm	rpm	NOUN
admet-2861	54	13	for	for	ADP
admet-2861	54	14	10	10	NUM
admet-2861	54	15	minutes	minute	NOUN
admet-2861	54	16	,	,	PUNCT
admet-2861	54	17	and	and	CCONJ
admet-2861	54	18	then	then	ADV
admet-2861	54	19	the	the	DET
admet-2861	54	20	supernatant	supernatant	NOUN
admet-2861	54	21	was	be	AUX
admet-2861	54	22	filtered	filter	VERB
admet-2861	54	23	through	through	ADP
admet-2861	54	24	a	a	DET
admet-2861	54	25	nylon	nylon	NOUN
admet-2861	54	26	filter	filter	NOUN
admet-2861	54	27	with	with	ADP
admet-2861	54	28	a	a	DET
admet-2861	54	29	pore	pore	ADJ
admet-2861	54	30	size	size	NOUN
admet-2861	54	31	of	of	ADP
admet-2861	54	32	0.22	0.22	NUM
admet-2861	54	33	µm	µm	NOUN
admet-2861	54	34	.	.	PUNCT
admet-2861	55	1	after	after	ADP
admet-2861	55	2	appropriate	appropriate	ADJ
admet-2861	55	3	dilution	dilution	NOUN
admet-2861	55	4	,	,	PUNCT
admet-2861	55	5	the	the	DET
admet-2861	55	6	sample	sample	NOUN
admet-2861	55	7	solutions	solution	NOUN
admet-2861	55	8	were	be	AUX
admet-2861	55	9	assayed	assayed	ADJ
admet-2861	55	10	for	for	ADP
admet-2861	55	11	bdp	bdp	PROPN
admet-2861	55	12	/	/	SYM
admet-2861	55	13	sx	sx	PROPN
admet-2861	55	14	using	use	VERB
admet-2861	55	15	the	the	DET
admet-2861	55	16	previously	previously	ADV
admet-2861	55	17	published	publish	VERB
admet-2861	55	18	hplc	hplc	NOUN
admet-2861	55	19	methods	method	NOUN
admet-2861	55	20	[	[	X
admet-2861	55	21	28,29	28,29	NUM
admet-2861	55	22	]	]	PUNCT
admet-2861	55	23	.	.	PUNCT
admet-2861	56	1	dissolution	dissolution	PROPN
admet-2861	56	2	test	test	NOUN
admet-2861	56	3	assembly	assembly	NOUN
admet-2861	56	4	the	the	DET
admet-2861	56	5	developed	develop	VERB
admet-2861	56	6	method	method	NOUN
admet-2861	56	7	for	for	ADP
admet-2861	56	8	testing	test	VERB
admet-2861	56	9	the	the	DET
admet-2861	56	10	dissolution	dissolution	NOUN
admet-2861	56	11	rate	rate	NOUN
admet-2861	56	12	of	of	ADP
admet-2861	56	13	inhalation	inhalation	NOUN
admet-2861	56	14	preparations	preparation	NOUN
admet-2861	56	15	is	be	AUX
admet-2861	56	16	based	base	VERB
admet-2861	56	17	on	on	ADP
admet-2861	56	18	the	the	DET
admet-2861	56	19	use	use	NOUN
admet-2861	56	20	of	of	ADP
admet-2861	56	21	an	an	DET
admet-2861	56	22	abbreviated	abbreviate	VERB
admet-2861	56	23	andersen	andersen	NOUN
admet-2861	56	24	cascade	cascade	NOUN
admet-2861	56	25	impactor	impactor	NOUN
admet-2861	56	26	(	(	PUNCT
admet-2861	56	27	aaci	aaci	PROPN
admet-2861	56	28	)	)	PUNCT
admet-2861	56	29	(	(	PUNCT
admet-2861	56	30	andersen	andersen	NOUN
admet-2861	56	31	cascade	cascade	NOUN
admet-2861	56	32	impactor	impactor	NOUN
admet-2861	56	33	,	,	PUNCT
admet-2861	56	34	erweka	erweka	PROPN
admet-2861	56	35	gmbh	gmbh	NOUN
admet-2861	56	36	,	,	PUNCT
admet-2861	56	37	germany	germany	PROPN
admet-2861	56	38	)	)	PUNCT
admet-2861	56	39	and	and	CCONJ
admet-2861	56	40	a	a	DET
admet-2861	56	41	modified	modify	VERB
admet-2861	56	42	paddle	paddle	NOUN
admet-2861	56	43	-	-	PUNCT
admet-2861	56	44	over	over	ADP
admet-2861	56	45	-	-	PUNCT
admet-2861	56	46	disc	disc	NOUN
admet-2861	56	47	apparatus	apparatus	NOUN
admet-2861	56	48	(	(	PUNCT
admet-2861	56	49	varian	varian	PROPN
admet-2861	56	50	vk	vk	PROPN
admet-2861	56	51	7010	7010	NUM
admet-2861	56	52	,	,	PUNCT
admet-2861	56	53	varian	varian	PROPN
admet-2861	56	54	inc	inc	PROPN
admet-2861	56	55	.	.	PROPN
admet-2861	56	56	,	,	PUNCT
admet-2861	56	57	usa	usa	PROPN
admet-2861	56	58	)	)	PUNCT
admet-2861	56	59	.	.	PUNCT
admet-2861	57	1	the	the	DET
admet-2861	57	2	paddle	paddle	NOUN
admet-2861	57	3	-	-	PUNCT
admet-2861	57	4	over	over	ADP
admet-2861	57	5	-	-	PUNCT
admet-2861	57	6	disc	disc	NOUN
admet-2861	57	7	apparatus	apparatus	NOUN
admet-2861	57	8	(	(	PUNCT
admet-2861	57	9	usp	usp	NOUN
admet-2861	57	10	app	app	PROPN
admet-2861	57	11	.	.	PROPN
admet-2861	57	12	5	5	NUM
admet-2861	57	13	)	)	PUNCT
admet-2861	57	14	was	be	AUX
admet-2861	57	15	chosen	choose	VERB
admet-2861	57	16	as	as	ADP
admet-2861	57	17	the	the	DET
admet-2861	57	18	basic	basic	ADJ
admet-2861	57	19	instrument	instrument	NOUN
admet-2861	57	20	for	for	ADP
admet-2861	57	21	developing	develop	VERB
admet-2861	57	22	the	the	DET
admet-2861	57	23	method	method	NOUN
admet-2861	57	24	.	.	PUNCT
admet-2861	58	1	the	the	DET
admet-2861	58	2	detailed	detailed	ADJ
admet-2861	58	3	dimensions	dimension	NOUN
admet-2861	58	4	of	of	ADP
admet-2861	58	5	the	the	DET
admet-2861	58	6	assembly	assembly	NOUN
admet-2861	58	7	are	be	AUX
admet-2861	58	8	given	give	VERB
admet-2861	58	9	in	in	ADP
admet-2861	58	10	figure	figure	NOUN
admet-2861	58	11	1	1	NUM
admet-2861	58	12	.	.	PUNCT
admet-2861	59	1	the	the	DET
admet-2861	59	2	membrane	membrane	NOUN
admet-2861	59	3	for	for	ADP
admet-2861	59	4	the	the	DET
admet-2861	59	5	dissolution	dissolution	PROPN
admet-2861	59	6	test	test	NOUN
admet-2861	59	7	assembly	assembly	NOUN
admet-2861	59	8	consisted	consist	VERB
admet-2861	59	9	of	of	ADP
admet-2861	59	10	agarose	agarose	NOUN
admet-2861	59	11	gel	gel	NOUN
admet-2861	59	12	prepared	prepare	VERB
admet-2861	59	13	as	as	ADP
admet-2861	59	14	a	a	DET
admet-2861	59	15	2	2	NUM
admet-2861	59	16	%	%	NOUN
admet-2861	59	17	agar	agar	NOUN
admet-2861	59	18	gel	gel	NOUN
admet-2861	59	19	in	in	ADP
admet-2861	59	20	a	a	DET
admet-2861	59	21	dissolution	dissolution	ADJ
admet-2861	59	22	medium	medium	NOUN
admet-2861	59	23	(	(	PUNCT
admet-2861	59	24	phosphate	phosphate	NOUN
admet-2861	59	25	-	-	PUNCT
admet-2861	59	26	buffered	buffer	VERB
admet-2861	59	27	saline	saline	NOUN
admet-2861	59	28	(	(	PUNCT
admet-2861	59	29	pbs	pbs	PROPN
admet-2861	59	30	)	)	PUNCT
admet-2861	59	31	with	with	ADP
admet-2861	59	32	or	or	CCONJ
admet-2861	59	33	without	without	ADP
admet-2861	59	34	1	1	NUM
admet-2861	59	35	%	%	NOUN
admet-2861	59	36	sodium	sodium	NOUN
admet-2861	59	37	dodecyl	dodecyl	NOUN
admet-2861	59	38	sulphate	sulphate	NOUN
admet-2861	59	39	(	(	PUNCT
admet-2861	59	40	sds	sds	PROPN
admet-2861	59	41	)	)	PUNCT
admet-2861	59	42	.	.	PUNCT
admet-2861	60	1	agar	agar	NOUN
admet-2861	60	2	and	and	CCONJ
admet-2861	60	3	sds	sds	PROPN
admet-2861	60	4	were	be	AUX
admet-2861	60	5	mixed	mix	VERB
admet-2861	60	6	with	with	ADP
admet-2861	60	7	pbs	pbs	PROPN
admet-2861	60	8	and	and	CCONJ
admet-2861	60	9	heated	heat	VERB
admet-2861	60	10	to	to	ADP
admet-2861	60	11	80	80	NUM
admet-2861	60	12	°	°	NOUN
admet-2861	60	13	c	c	NOUN
admet-2861	60	14	.	.	PUNCT
admet-2861	61	1	a	a	DET
admet-2861	61	2	quantity	quantity	NOUN
admet-2861	61	3	of	of	ADP
admet-2861	61	4	4.5	4.5	NUM
admet-2861	61	5	ml	ml	NOUN
admet-2861	61	6	of	of	ADP
admet-2861	61	7	the	the	DET
admet-2861	61	8	mixture	mixture	NOUN
admet-2861	61	9	was	be	AUX
admet-2861	61	10	poured	pour	VERB
admet-2861	61	11	into	into	ADP
admet-2861	61	12	the	the	DET
admet-2861	61	13	recess	recess	NOUN
admet-2861	61	14	on	on	ADP
admet-2861	61	15	the	the	DET
admet-2861	61	16	back	back	NOUN
admet-2861	61	17	of	of	ADP
admet-2861	61	18	the	the	DET
admet-2861	61	19	aci	aci	NOUN
admet-2861	61	20	plate	plate	NOUN
admet-2861	61	21	and	and	CCONJ
admet-2861	61	22	evenly	evenly	ADV
admet-2861	61	23	distributed	distribute	VERB
admet-2861	61	24	over	over	ADP
admet-2861	61	25	the	the	DET
admet-2861	61	26	surface	surface	NOUN
admet-2861	61	27	.	.	PUNCT
admet-2861	62	1	a	a	DET
admet-2861	62	2	glass	glass	NOUN
admet-2861	62	3	fiber	fiber	NOUN
admet-2861	62	4	filter	filter	NOUN
admet-2861	62	5	was	be	AUX
admet-2861	62	6	immersed	immerse	VERB
admet-2861	62	7	in	in	ADP
admet-2861	62	8	the	the	DET
admet-2861	62	9	still	still	ADV
admet-2861	62	10	liquid	liquid	ADJ
admet-2861	62	11	solution	solution	NOUN
admet-2861	62	12	and	and	CCONJ
admet-2861	62	13	allowed	allow	VERB
admet-2861	62	14	to	to	PART
admet-2861	62	15	soak	soak	VERB
admet-2861	62	16	and	and	CCONJ
admet-2861	62	17	sink	sink	VERB
admet-2861	62	18	into	into	ADP
admet-2861	62	19	the	the	DET
admet-2861	62	20	agar	agar	NOUN
admet-2861	62	21	.	.	PUNCT
admet-2861	63	1	the	the	DET
admet-2861	63	2	plate	plate	NOUN
admet-2861	63	3	was	be	AUX
admet-2861	63	4	then	then	ADV
admet-2861	63	5	transferred	transfer	VERB
admet-2861	63	6	to	to	ADP
admet-2861	63	7	moist	moist	ADJ
admet-2861	63	8	tissue	tissue	NOUN
admet-2861	63	9	paper	paper	NOUN
admet-2861	63	10	and	and	CCONJ
admet-2861	63	11	covered	cover	VERB
admet-2861	63	12	with	with	ADP
admet-2861	63	13	a	a	DET
admet-2861	63	14	petri	petri	ADJ
admet-2861	63	15	dish	dish	NOUN
admet-2861	63	16	to	to	PART
admet-2861	63	17	allow	allow	VERB
admet-2861	63	18	the	the	DET
admet-2861	63	19	agar	agar	NOUN
admet-2861	63	20	to	to	PART
admet-2861	63	21	solidify	solidify	VERB
admet-2861	63	22	and	and	CCONJ
admet-2861	63	23	gel	gel	VERB
admet-2861	63	24	without	without	ADP
admet-2861	63	25	drying	dry	VERB
admet-2861	63	26	out	out	ADP
admet-2861	63	27	.	.	PUNCT
admet-2861	64	1	figure	figure	NOUN
admet-2861	64	2	1	1	NUM
admet-2861	64	3	.	.	PUNCT
admet-2861	65	1	presentation	presentation	NOUN
admet-2861	65	2	of	of	ADP
admet-2861	65	3	the	the	DET
admet-2861	65	4	experimental	experimental	ADJ
admet-2861	65	5	setup	setup	NOUN
admet-2861	65	6	for	for	ADP
admet-2861	65	7	testing	test	VERB
admet-2861	65	8	the	the	DET
admet-2861	65	9	dissolution	dissolution	NOUN
admet-2861	65	10	rate	rate	NOUN
admet-2861	65	11	of	of	ADP
admet-2861	65	12	the	the	DET
admet-2861	65	13	active	active	ADJ
admet-2861	65	14	substance	substance	NOUN
admet-2861	65	15	from	from	ADP
admet-2861	65	16	the	the	DET
admet-2861	65	17	inhalation	inhalation	NOUN
admet-2861	65	18	preparation	preparation	NOUN
admet-2861	65	19	[	[	X
admet-2861	65	20	27	27	NUM
admet-2861	65	21	]	]	PUNCT
admet-2861	65	22	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	65	23	https://pv-systems.pl/en/products/copley-scientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	https://pv-systems.pl/en/products/copley-scientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	PROPN
admet-2861	65	24	https://pv-systems.pl/en/products/copley-scientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	https://pv-systems.pl/en/products/copley-scientific/19-inhaler-testing/ancillaries/100-copley-inhaler-testing-data-analysis-software-citdas	PROPN
admet-2861	65	25	a.	a.	PROPN
admet-2861	65	26	elezović	elezović	PROPN
admet-2861	65	27	et	et	PROPN
admet-2861	65	28	al	al	PROPN
admet-2861	65	29	.	.	PROPN
admet-2861	65	30	admet	admet	PROPN
admet-2861	65	31	&	&	CCONJ
admet-2861	65	32	dmpk	dmpk	PROPN
admet-2861	65	33	13(5	13(5	NUM
admet-2861	65	34	)	)	PUNCT
admet-2861	65	35	(	(	PUNCT
admet-2861	65	36	2025	2025	NUM
admet-2861	65	37	)	)	PUNCT
admet-2861	65	38	2861	2861	NUM
admet-2861	65	39	4	4	NUM
admet-2861	65	40	dissolution	dissolution	NOUN
admet-2861	65	41	test	test	NOUN
admet-2861	65	42	procedure	procedure	NOUN
admet-2861	65	43	samples	sample	NOUN
admet-2861	65	44	for	for	ADP
admet-2861	65	45	dissolution	dissolution	NOUN
admet-2861	65	46	testing	testing	NOUN
admet-2861	65	47	were	be	AUX
admet-2861	65	48	obtained	obtain	VERB
admet-2861	65	49	using	use	VERB
admet-2861	65	50	the	the	DET
admet-2861	65	51	aaci	aaci	NOUN
admet-2861	65	52	.	.	PUNCT
admet-2861	66	1	using	use	VERB
admet-2861	66	2	the	the	DET
admet-2861	66	3	arrangement	arrangement	NOUN
admet-2861	66	4	of	of	ADP
admet-2861	66	5	stages	stage	NOUN
admet-2861	66	6	0	0	NUM
admet-2861	66	7	,	,	PUNCT
admet-2861	66	8	1	1	NUM
admet-2861	66	9	,	,	PUNCT
admet-2861	66	10	2	2	NUM
admet-2861	66	11	,	,	PUNCT
admet-2861	66	12	7	7	NUM
admet-2861	66	13	and	and	CCONJ
admet-2861	66	14	the	the	DET
admet-2861	66	15	filter	filter	NOUN
admet-2861	66	16	stage	stage	NOUN
admet-2861	66	17	,	,	PUNCT
admet-2861	66	18	the	the	DET
admet-2861	66	19	fraction	fraction	NOUN
admet-2861	66	20	of	of	ADP
admet-2861	66	21	particles	particle	NOUN
admet-2861	66	22	with	with	ADP
admet-2861	66	23	an	an	DET
admet-2861	66	24	aerodynamic	aerodynamic	ADJ
admet-2861	66	25	diameter	diameter	NOUN
admet-2861	66	26	ranging	range	VERB
admet-2861	66	27	from	from	ADP
admet-2861	66	28	4.7	4.7	NUM
admet-2861	66	29	to	to	PART
admet-2861	66	30	0.2	0.2	NUM
admet-2861	66	31	µm	µm	NUM
admet-2861	66	32	was	be	AUX
admet-2861	66	33	collected	collect	VERB
admet-2861	66	34	.	.	PUNCT
admet-2861	67	1	after	after	SCONJ
admet-2861	67	2	the	the	DET
admet-2861	67	3	inhaler	inhaler	NOUN
admet-2861	67	4	doses	dose	NOUN
admet-2861	67	5	were	be	AUX
admet-2861	67	6	collected	collect	VERB
admet-2861	67	7	on	on	ADP
admet-2861	67	8	the	the	DET
admet-2861	67	9	membrane	membrane	NOUN
admet-2861	67	10	,	,	PUNCT
admet-2861	67	11	it	it	PRON
admet-2861	67	12	was	be	AUX
admet-2861	67	13	inverted	invert	VERB
admet-2861	67	14	onto	onto	ADP
admet-2861	67	15	the	the	DET
admet-2861	67	16	back	back	NOUN
admet-2861	67	17	of	of	ADP
admet-2861	67	18	the	the	DET
admet-2861	67	19	second	second	ADJ
admet-2861	67	20	plate	plate	NOUN
admet-2861	67	21	of	of	ADP
admet-2861	67	22	the	the	DET
admet-2861	67	23	cascade	cascade	NOUN
admet-2861	67	24	impactor	impactor	NOUN
admet-2861	67	25	,	,	PUNCT
admet-2861	67	26	carefully	carefully	ADV
admet-2861	67	27	pressed	press	VERB
admet-2861	67	28	to	to	PART
admet-2861	67	29	remove	remove	VERB
admet-2861	67	30	air	air	NOUN
admet-2861	67	31	from	from	ADP
admet-2861	67	32	under	under	ADP
admet-2861	67	33	the	the	DET
admet-2861	67	34	membrane	membrane	NOUN
admet-2861	67	35	,	,	PUNCT
admet-2861	67	36	and	and	CCONJ
admet-2861	67	37	fixed	fix	VERB
admet-2861	67	38	with	with	ADP
admet-2861	67	39	aluminium	aluminium	NOUN
admet-2861	67	40	clips	clip	NOUN
admet-2861	67	41	.	.	PUNCT
admet-2861	68	1	this	this	DET
admet-2861	68	2	system	system	NOUN
admet-2861	68	3	was	be	AUX
admet-2861	68	4	immersed	immerse	VERB
admet-2861	68	5	in	in	ADP
admet-2861	68	6	a	a	DET
admet-2861	68	7	flat	flat	ADJ
admet-2861	68	8	-	-	PUNCT
admet-2861	68	9	bottom	bottom	NOUN
admet-2861	68	10	dissolution	dissolution	NOUN
admet-2861	68	11	vessel	vessel	NOUN
admet-2861	68	12	with	with	ADP
admet-2861	68	13	a	a	DET
admet-2861	68	14	1	1	NUM
admet-2861	68	15	l	l	NOUN
admet-2861	68	16	volume	volume	NOUN
admet-2861	68	17	and	and	CCONJ
admet-2861	68	18	a	a	DET
admet-2861	68	19	diameter	diameter	NOUN
admet-2861	68	20	of	of	ADP
admet-2861	68	21	93	93	NUM
admet-2861	68	22	mm	mm	NOUN
admet-2861	68	23	.	.	PUNCT
admet-2861	69	1	the	the	DET
admet-2861	69	2	vessel	vessel	NOUN
admet-2861	69	3	was	be	AUX
admet-2861	69	4	placed	place	VERB
admet-2861	69	5	in	in	ADP
admet-2861	69	6	a	a	DET
admet-2861	69	7	dissolution	dissolution	ADJ
admet-2861	69	8	tester	tester	NOUN
admet-2861	69	9	with	with	ADP
admet-2861	69	10	a	a	DET
admet-2861	69	11	rotating	rotate	VERB
admet-2861	69	12	paddle	paddle	NOUN
admet-2861	69	13	,	,	PUNCT
admet-2861	69	14	positioned	position	VERB
admet-2861	69	15	23	23	NUM
admet-2861	69	16	mm	mm	NOUN
admet-2861	69	17	from	from	ADP
admet-2861	69	18	the	the	DET
admet-2861	69	19	bottom	bottom	NOUN
admet-2861	69	20	of	of	ADP
admet-2861	69	21	the	the	DET
admet-2861	69	22	vessel	vessel	NOUN
admet-2861	69	23	.	.	PUNCT
admet-2861	70	1	300	300	NUM
admet-2861	70	2	ml	ml	NOUN
admet-2861	70	3	of	of	ADP
admet-2861	70	4	dissolution	dissolution	NOUN
admet-2861	70	5	media	medium	NOUN
admet-2861	70	6	,	,	PUNCT
admet-2861	70	7	heated	heat	VERB
admet-2861	70	8	to	to	ADP
admet-2861	70	9	37.5	37.5	NUM
admet-2861	70	10	°	°	NOUN
admet-2861	70	11	c	c	NOUN
admet-2861	70	12	(	(	PUNCT
admet-2861	70	13	pbs	pbs	PROPN
admet-2861	70	14	without	without	ADP
admet-2861	70	15	sds	sds	PROPN
admet-2861	70	16	for	for	ADP
admet-2861	70	17	sx	sx	PROPN
admet-2861	70	18	or	or	CCONJ
admet-2861	70	19	with	with	ADP
admet-2861	70	20	1	1	NUM
admet-2861	70	21	%	%	NOUN
admet-2861	70	22	sds	sds	NOUN
admet-2861	70	23	for	for	ADP
admet-2861	70	24	bdp	bdp	PROPN
admet-2861	70	25	testing	testing	PROPN
admet-2861	70	26	)	)	PUNCT
admet-2861	70	27	,	,	PUNCT
admet-2861	70	28	was	be	AUX
admet-2861	70	29	used	use	VERB
admet-2861	70	30	.	.	PUNCT
admet-2861	71	1	the	the	DET
admet-2861	71	2	speed	speed	NOUN
admet-2861	71	3	of	of	ADP
admet-2861	71	4	the	the	DET
admet-2861	71	5	paddle	paddle	NOUN
admet-2861	71	6	rotation	rotation	NOUN
admet-2861	71	7	was	be	AUX
admet-2861	71	8	set	set	VERB
admet-2861	71	9	to	to	ADP
admet-2861	71	10	100	100	NUM
admet-2861	71	11	revolutions	revolution	NOUN
admet-2861	71	12	per	per	ADP
admet-2861	71	13	minute	minute	NOUN
admet-2861	71	14	(	(	PUNCT
admet-2861	71	15	rpm	rpm	PROPN
admet-2861	71	16	)	)	PUNCT
admet-2861	71	17	.	.	PUNCT
admet-2861	72	1	at	at	ADP
admet-2861	72	2	the	the	DET
admet-2861	72	3	specified	specified	ADJ
admet-2861	72	4	time	time	NOUN
admet-2861	72	5	intervals	interval	NOUN
admet-2861	72	6	,	,	PUNCT
admet-2861	72	7	sampling	sample	VERB
admet-2861	72	8	was	be	AUX
admet-2861	72	9	performed	perform	VERB
admet-2861	72	10	with	with	ADP
admet-2861	72	11	a	a	DET
admet-2861	72	12	probe	probe	NOUN
admet-2861	72	13	along	along	ADP
admet-2861	72	14	the	the	DET
admet-2861	72	15	edge	edge	NOUN
admet-2861	72	16	of	of	ADP
admet-2861	72	17	the	the	DET
admet-2861	72	18	vessel	vessel	NOUN
admet-2861	72	19	at	at	ADP
admet-2861	72	20	a	a	DET
admet-2861	72	21	height	height	NOUN
admet-2861	72	22	of	of	ADP
admet-2861	72	23	25	25	NUM
admet-2861	72	24	mm	mm	NOUN
admet-2861	72	25	from	from	ADP
admet-2861	72	26	the	the	DET
admet-2861	72	27	bottom	bottom	NOUN
admet-2861	72	28	of	of	ADP
admet-2861	72	29	the	the	DET
admet-2861	72	30	vessel	vessel	NOUN
admet-2861	72	31	and	and	CCONJ
admet-2861	72	32	5	5	NUM
admet-2861	72	33	mm	mm	NOUN
admet-2861	72	34	from	from	ADP
admet-2861	72	35	the	the	DET
admet-2861	72	36	wall	wall	NOUN
admet-2861	72	37	of	of	ADP
admet-2861	72	38	the	the	DET
admet-2861	72	39	vessel	vessel	NOUN
admet-2861	72	40	.	.	PUNCT
admet-2861	73	1	the	the	DET
admet-2861	73	2	sample	sample	NOUN
admet-2861	73	3	volume	volume	NOUN
admet-2861	73	4	was	be	AUX
admet-2861	73	5	1	1	NUM
admet-2861	73	6	ml	ml	NOUN
admet-2861	73	7	,	,	PUNCT
admet-2861	73	8	and	and	CCONJ
admet-2861	73	9	after	after	ADP
admet-2861	73	10	each	each	DET
admet-2861	73	11	sampling	sampling	NOUN
admet-2861	73	12	,	,	PUNCT
admet-2861	73	13	the	the	DET
admet-2861	73	14	same	same	ADJ
admet-2861	73	15	volume	volume	NOUN
admet-2861	73	16	of	of	ADP
admet-2861	73	17	fresh	fresh	ADJ
admet-2861	73	18	medium	medium	NOUN
admet-2861	73	19	was	be	AUX
admet-2861	73	20	added	add	VERB
admet-2861	73	21	to	to	ADP
admet-2861	73	22	the	the	DET
admet-2861	73	23	vessel	vessel	NOUN
admet-2861	73	24	.	.	PUNCT
admet-2861	74	1	experimentally	experimentally	ADV
admet-2861	74	2	obtained	obtain	VERB
admet-2861	74	3	dissolution	dissolution	NOUN
admet-2861	74	4	profiles	profile	NOUN
admet-2861	74	5	were	be	AUX
admet-2861	74	6	evaluated	evaluate	VERB
admet-2861	74	7	using	use	VERB
admet-2861	74	8	model	model	NOUN
admet-2861	74	9	-	-	PUNCT
admet-2861	74	10	dependent	dependent	ADJ
admet-2861	74	11	methods	method	NOUN
admet-2861	74	12	(	(	PUNCT
admet-2861	74	13	zeroorder	zeroorder	NOUN
admet-2861	74	14	,	,	PUNCT
admet-2861	74	15	first	first	ADJ
admet-2861	74	16	-	-	PUNCT
admet-2861	74	17	order	order	NOUN
admet-2861	74	18	,	,	PUNCT
admet-2861	74	19	higuchi	higuchi	ADJ
admet-2861	74	20	,	,	PUNCT
admet-2861	74	21	and	and	CCONJ
admet-2861	74	22	hixon	hixon	NOUN
admet-2861	74	23	-	-	PUNCT
admet-2861	74	24	crowell	crowell	NOUN
admet-2861	74	25	models	model	NOUN
admet-2861	74	26	)	)	PUNCT
admet-2861	74	27	.	.	PUNCT
admet-2861	75	1	comparison	comparison	NOUN
admet-2861	75	2	of	of	ADP
admet-2861	75	3	drug	drug	NOUN
admet-2861	75	4	dissolution	dissolution	NOUN
admet-2861	75	5	profiles	profile	NOUN
admet-2861	75	6	from	from	ADP
admet-2861	75	7	different	different	ADJ
admet-2861	75	8	products	product	NOUN
admet-2861	75	9	was	be	AUX
admet-2861	75	10	made	make	VERB
admet-2861	75	11	using	use	VERB
admet-2861	75	12	model	model	NOUN
admet-2861	75	13	-	-	PUNCT
admet-2861	75	14	independent	independent	ADJ
admet-2861	75	15	methods	method	NOUN
admet-2861	75	16	(	(	PUNCT
admet-2861	75	17	difference	difference	NOUN
admet-2861	75	18	factor	factor	NOUN
admet-2861	75	19	f1	f1	NOUN
admet-2861	75	20	and	and	CCONJ
admet-2861	75	21	similarity	similarity	NOUN
admet-2861	75	22	factor	factor	NOUN
admet-2861	75	23	f2	f2	PROPN
admet-2861	75	24	)	)	PUNCT
admet-2861	75	25	.	.	PUNCT
admet-2861	76	1	data	datum	NOUN
admet-2861	76	2	analysis	analysis	NOUN
admet-2861	76	3	was	be	AUX
admet-2861	76	4	performed	perform	VERB
admet-2861	76	5	using	use	VERB
admet-2861	76	6	microsoft	microsoft	PROPN
admet-2861	76	7	®	®	PROPN
admet-2861	76	8	excel	excel	PROPN
admet-2861	76	9	®	®	PROPN
admet-2861	76	10	.	.	PUNCT
admet-2861	77	1	design	design	NOUN
admet-2861	77	2	of	of	ADP
admet-2861	77	3	in	in	ADP
admet-2861	77	4	silico	silico	NOUN
admet-2861	77	5	models	model	NOUN
admet-2861	77	6	in	in	ADP
admet-2861	77	7	silico	silico	NOUN
admet-2861	77	8	compartmental	compartmental	NOUN
admet-2861	77	9	models	model	NOUN
admet-2861	77	10	of	of	ADP
admet-2861	77	11	the	the	DET
admet-2861	77	12	absorption	absorption	NOUN
admet-2861	77	13	,	,	PUNCT
admet-2861	77	14	distribution	distribution	NOUN
admet-2861	77	15	,	,	PUNCT
admet-2861	77	16	and	and	CCONJ
admet-2861	77	17	elimination	elimination	NOUN
admet-2861	77	18	of	of	ADP
admet-2861	77	19	the	the	DET
admet-2861	77	20	model	model	NOUN
admet-2861	77	21	drugs	drug	NOUN
admet-2861	77	22	in	in	ADP
admet-2861	77	23	the	the	DET
admet-2861	77	24	human	human	ADJ
admet-2861	77	25	body	body	NOUN
admet-2861	77	26	were	be	AUX
admet-2861	77	27	created	create	VERB
admet-2861	77	28	using	use	VERB
admet-2861	77	29	the	the	DET
admet-2861	77	30	gastroplus	gastroplus	ADJ
admet-2861	77	31	®	®	NOUN
admet-2861	77	32	software	software	NOUN
admet-2861	77	33	package	package	NOUN
admet-2861	77	34	(	(	PUNCT
admet-2861	77	35	v.	v.	ADP
admet-2861	77	36	9.8	9.8	NUM
admet-2861	77	37	,	,	PUNCT
admet-2861	77	38	simulations	simulation	NOUN
admet-2861	77	39	plus	plus	CCONJ
admet-2861	77	40	inc	inc	PROPN
admet-2861	77	41	.	.	PROPN
admet-2861	77	42	,	,	PUNCT
admet-2861	77	43	lancaster	lancaster	PROPN
admet-2861	77	44	,	,	PUNCT
admet-2861	77	45	usa	usa	PROPN
admet-2861	77	46	,	,	PUNCT
admet-2861	77	47	https://www.simulations-plus.com/software/gastroplus/	https://www.simulations-plus.com/software/gastroplus/	NOUN
admet-2861	77	48	)	)	PUNCT
admet-2861	77	49	.	.	PUNCT
admet-2861	78	1	available	available	ADJ
admet-2861	78	2	data	datum	NOUN
admet-2861	78	3	from	from	ADP
admet-2861	78	4	the	the	DET
admet-2861	78	5	literature	literature	NOUN
admet-2861	78	6	were	be	AUX
admet-2861	78	7	used	use	VERB
admet-2861	78	8	to	to	PART
admet-2861	78	9	create	create	VERB
admet-2861	78	10	a	a	DET
admet-2861	78	11	two	two	NUM
admet-2861	78	12	-	-	PUNCT
admet-2861	78	13	compartment	compartment	NOUN
admet-2861	78	14	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	78	15	model	model	NOUN
admet-2861	78	16	in	in	ADP
admet-2861	78	17	order	order	NOUN
admet-2861	78	18	to	to	PART
admet-2861	78	19	describe	describe	VERB
admet-2861	78	20	the	the	DET
admet-2861	78	21	intravenous	intravenous	ADJ
admet-2861	78	22	and	and	CCONJ
admet-2861	78	23	oral	oral	ADJ
admet-2861	78	24	administration	administration	NOUN
admet-2861	78	25	of	of	ADP
admet-2861	78	26	bdp	bdp	PROPN
admet-2861	78	27	.	.	PROPN
admet-2861	79	1	predicted	predict	VERB
admet-2861	79	2	plasma	plasma	NOUN
admet-2861	79	3	concentration	concentration	NOUN
admet-2861	79	4	-	-	PUNCT
admet-2861	79	5	time	time	NOUN
admet-2861	79	6	(	(	PUNCT
admet-2861	79	7	cp	cp	PROPN
admet-2861	79	8	-	-	PUNCT
admet-2861	79	9	t	t	NOUN
admet-2861	79	10	)	)	PUNCT
admet-2861	79	11	curves	curve	NOUN
admet-2861	79	12	of	of	ADP
admet-2861	79	13	bdp	bdp	PROPN
admet-2861	79	14	and	and	CCONJ
admet-2861	79	15	its	its	PRON
admet-2861	79	16	main	main	ADJ
admet-2861	79	17	active	active	ADJ
admet-2861	79	18	metabolite	metabolite	NOUN
admet-2861	79	19	,	,	PUNCT
admet-2861	79	20	beclomethasone	beclomethasone	ADJ
admet-2861	79	21	17	17	NUM
admet-2861	79	22	-	-	PUNCT
admet-2861	79	23	monopropionate	monopropionate	NOUN
admet-2861	79	24	,	,	PUNCT
admet-2861	79	25	were	be	AUX
admet-2861	79	26	compared	compare	VERB
admet-2861	79	27	with	with	ADP
admet-2861	79	28	published	publish	VERB
admet-2861	79	29	in	in	ADP
admet-2861	79	30	vivo	vivo	ADJ
admet-2861	79	31	data	datum	NOUN
admet-2861	79	32	[	[	X
admet-2861	79	33	30	30	NUM
admet-2861	79	34	]	]	PUNCT
admet-2861	79	35	to	to	PART
admet-2861	79	36	confirm	confirm	VERB
admet-2861	79	37	the	the	DET
admet-2861	79	38	validity	validity	NOUN
admet-2861	79	39	of	of	ADP
admet-2861	79	40	the	the	DET
admet-2861	79	41	models	model	NOUN
admet-2861	79	42	.	.	PUNCT
admet-2861	80	1	the	the	DET
admet-2861	80	2	models	model	NOUN
admet-2861	80	3	were	be	AUX
admet-2861	80	4	further	far	ADV
admet-2861	80	5	expanded	expand	VERB
admet-2861	80	6	to	to	PART
admet-2861	80	7	account	account	VERB
admet-2861	80	8	for	for	ADP
admet-2861	80	9	drug	drug	NOUN
admet-2861	80	10	absorption	absorption	NOUN
admet-2861	80	11	through	through	ADP
admet-2861	80	12	the	the	DET
admet-2861	80	13	lungs	lung	NOUN
admet-2861	80	14	,	,	PUNCT
admet-2861	80	15	and	and	CCONJ
admet-2861	80	16	for	for	ADP
admet-2861	80	17	this	this	DET
admet-2861	80	18	purpose	purpose	NOUN
admet-2861	80	19	,	,	PUNCT
admet-2861	80	20	the	the	DET
admet-2861	80	21	pulmonary	pulmonary	ADJ
admet-2861	80	22	compartmental	compartmental	NOUN
admet-2861	80	23	absorption	absorption	NOUN
admet-2861	80	24	and	and	CCONJ
admet-2861	80	25	transit	transit	NOUN
admet-2861	80	26	(	(	PUNCT
admet-2861	80	27	pcat	pcat	PROPN
admet-2861	80	28	™	™	PROPN
admet-2861	80	29	)	)	PUNCT
admet-2861	80	30	module	module	NOUN
admet-2861	80	31	of	of	ADP
admet-2861	80	32	gastroplus	gastroplus	ADJ
admet-2861	80	33	®	®	NOUN
admet-2861	80	34	was	be	AUX
admet-2861	80	35	used	use	VERB
admet-2861	80	36	.	.	PUNCT
admet-2861	81	1	parameters	parameter	NOUN
admet-2861	81	2	specific	specific	ADJ
admet-2861	81	3	to	to	ADP
admet-2861	81	4	each	each	DET
admet-2861	81	5	product	product	NOUN
admet-2861	81	6	included	include	VERB
admet-2861	81	7	the	the	DET
admet-2861	81	8	percentage	percentage	NOUN
admet-2861	81	9	of	of	ADP
admet-2861	81	10	drug	drug	NOUN
admet-2861	81	11	deposition	deposition	NOUN
admet-2861	81	12	in	in	ADP
admet-2861	81	13	the	the	DET
admet-2861	81	14	respiratory	respiratory	ADJ
admet-2861	81	15	tract	tract	NOUN
admet-2861	81	16	,	,	PUNCT
admet-2861	81	17	which	which	PRON
admet-2861	81	18	was	be	AUX
admet-2861	81	19	calculated	calculate	VERB
admet-2861	81	20	from	from	ADP
admet-2861	81	21	data	datum	NOUN
admet-2861	81	22	on	on	ADP
admet-2861	81	23	the	the	DET
admet-2861	81	24	aerodynamic	aerodynamic	ADJ
admet-2861	81	25	assessment	assessment	NOUN
admet-2861	81	26	of	of	ADP
admet-2861	81	27	fine	fine	ADJ
admet-2861	81	28	particles	particle	NOUN
admet-2861	81	29	using	use	VERB
admet-2861	81	30	a	a	DET
admet-2861	81	31	procedure	procedure	NOUN
admet-2861	81	32	published	publish	VERB
admet-2861	81	33	elsewhere	elsewhere	ADV
admet-2861	81	34	[	[	X
admet-2861	81	35	31	31	NUM
admet-2861	81	36	]	]	PUNCT
admet-2861	81	37	.	.	PUNCT
admet-2861	82	1	data	datum	NOUN
admet-2861	82	2	from	from	ADP
admet-2861	82	3	published	publish	VERB
admet-2861	82	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	82	5	studies	study	NOUN
admet-2861	82	6	of	of	ADP
admet-2861	82	7	tested	test	VERB
admet-2861	82	8	products	product	NOUN
admet-2861	82	9	[	[	X
admet-2861	82	10	32,33	32,33	NUM
admet-2861	82	11	]	]	PUNCT
admet-2861	82	12	were	be	AUX
admet-2861	82	13	used	use	VERB
admet-2861	82	14	to	to	PART
admet-2861	82	15	optimize	optimize	VERB
admet-2861	82	16	and	and	CCONJ
admet-2861	82	17	validate	validate	VERB
admet-2861	82	18	the	the	DET
admet-2861	82	19	pulmonary	pulmonary	NOUN
admet-2861	82	20	in	in	ADP
admet-2861	82	21	silico	silico	NOUN
admet-2861	82	22	model	model	NOUN
admet-2861	82	23	.	.	PUNCT
admet-2861	83	1	results	result	NOUN
admet-2861	83	2	and	and	CCONJ
admet-2861	83	3	discussion	discussion	VERB
admet-2861	83	4	the	the	DET
admet-2861	83	5	composition	composition	NOUN
admet-2861	83	6	of	of	ADP
admet-2861	83	7	the	the	DET
admet-2861	83	8	investigated	investigate	VERB
admet-2861	83	9	products	product	NOUN
admet-2861	83	10	and	and	CCONJ
admet-2861	83	11	their	their	PRON
admet-2861	83	12	experimentally	experimentally	ADV
admet-2861	83	13	determined	determine	VERB
admet-2861	83	14	aerodynamic	aerodynamic	ADJ
admet-2861	83	15	properties	property	NOUN
admet-2861	83	16	(	(	PUNCT
admet-2861	83	17	mmad	mmad	NOUN
admet-2861	83	18	and	and	CCONJ
admet-2861	83	19	fpf	fpf	NOUN
admet-2861	83	20	)	)	PUNCT
admet-2861	83	21	are	be	AUX
admet-2861	83	22	presented	present	VERB
admet-2861	83	23	in	in	ADP
admet-2861	83	24	table	table	NOUN
admet-2861	83	25	1	1	NUM
admet-2861	83	26	.	.	PUNCT
admet-2861	84	1	the	the	DET
admet-2861	84	2	results	result	NOUN
admet-2861	84	3	of	of	ADP
admet-2861	84	4	the	the	DET
admet-2861	84	5	determination	determination	NOUN
admet-2861	84	6	of	of	ADP
admet-2861	84	7	the	the	DET
admet-2861	84	8	aerodynamic	aerodynamic	ADJ
admet-2861	84	9	particle	particle	NOUN
admet-2861	84	10	size	size	NOUN
admet-2861	84	11	distribution	distribution	NOUN
admet-2861	84	12	of	of	ADP
admet-2861	84	13	the	the	DET
admet-2861	84	14	tested	test	VERB
admet-2861	84	15	products	product	NOUN
admet-2861	84	16	containing	contain	VERB
admet-2861	84	17	bdp	bdp	PROPN
admet-2861	84	18	and	and	CCONJ
admet-2861	84	19	sx	sx	PROPN
admet-2861	84	20	,	,	PUNCT
admet-2861	84	21	obtained	obtain	VERB
admet-2861	84	22	using	use	VERB
admet-2861	84	23	the	the	DET
admet-2861	84	24	ngi	ngi	PROPN
admet-2861	84	25	,	,	PUNCT
admet-2861	84	26	are	be	AUX
admet-2861	84	27	presented	present	VERB
admet-2861	84	28	in	in	ADP
admet-2861	84	29	figures	figure	NOUN
admet-2861	84	30	2	2	NUM
admet-2861	84	31	and	and	CCONJ
admet-2861	84	32	3	3	NUM
admet-2861	84	33	,	,	PUNCT
admet-2861	84	34	respectively	respectively	ADV
admet-2861	84	35	.	.	PUNCT
admet-2861	85	1	when	when	SCONJ
admet-2861	85	2	observing	observe	VERB
admet-2861	85	3	the	the	DET
admet-2861	85	4	results	result	NOUN
admet-2861	85	5	obtained	obtain	VERB
admet-2861	85	6	from	from	ADP
admet-2861	85	7	testing	test	VERB
admet-2861	85	8	products	product	NOUN
admet-2861	85	9	containing	contain	VERB
admet-2861	85	10	bdp	bdp	PROPN
admet-2861	85	11	,	,	PUNCT
admet-2861	85	12	it	it	PRON
admet-2861	85	13	is	be	AUX
admet-2861	85	14	noticeable	noticeable	ADJ
admet-2861	85	15	that	that	SCONJ
admet-2861	85	16	the	the	DET
admet-2861	85	17	highest	high	ADJ
admet-2861	85	18	proportion	proportion	NOUN
admet-2861	85	19	of	of	ADP
admet-2861	85	20	fine	fine	ADJ
admet-2861	85	21	particles	particle	NOUN
admet-2861	85	22	(	(	PUNCT
admet-2861	85	23	fpf	fpf	NOUN
admet-2861	85	24	)	)	PUNCT
admet-2861	85	25	was	be	AUX
admet-2861	85	26	in	in	ADP
admet-2861	85	27	preparation	preparation	NOUN
admet-2861	85	28	b1	b1	NOUN
admet-2861	85	29	,	,	PUNCT
admet-2861	85	30	while	while	SCONJ
admet-2861	85	31	the	the	DET
admet-2861	85	32	other	other	ADJ
admet-2861	85	33	two	two	NUM
admet-2861	85	34	products	product	NOUN
admet-2861	85	35	had	have	VERB
admet-2861	85	36	similar	similar	ADJ
admet-2861	85	37	values	value	NOUN
admet-2861	85	38	of	of	ADP
admet-2861	85	39	fine	fine	ADJ
admet-2861	85	40	particle	particle	NOUN
admet-2861	85	41	fraction	fraction	NOUN
admet-2861	85	42	.	.	PUNCT
admet-2861	86	1	the	the	DET
admet-2861	86	2	difference	difference	NOUN
admet-2861	86	3	was	be	AUX
admet-2861	86	4	also	also	ADV
admet-2861	86	5	noticeable	noticeable	ADJ
admet-2861	86	6	in	in	ADP
admet-2861	86	7	the	the	DET
admet-2861	86	8	mmad	mmad	ADJ
admet-2861	86	9	values	value	NOUN
admet-2861	86	10	(	(	PUNCT
admet-2861	86	11	table	table	NOUN
admet-2861	86	12	1	1	NUM
admet-2861	86	13	)	)	PUNCT
admet-2861	86	14	,	,	PUNCT
admet-2861	86	15	which	which	PRON
admet-2861	86	16	ranged	range	VERB
admet-2861	86	17	from	from	ADP
admet-2861	86	18	0.880	0.880	NUM
admet-2861	86	19	µm	µm	NOUN
admet-2861	86	20	in	in	ADP
admet-2861	86	21	product	product	NOUN
admet-2861	86	22	b1	b1	NOUN
admet-2861	86	23	to	to	ADP
admet-2861	86	24	1.028	1.028	NUM
admet-2861	86	25	µm	µm	NOUN
admet-2861	86	26	in	in	ADP
admet-2861	86	27	product	product	NOUN
admet-2861	86	28	b2	b2	NOUN
admet-2861	86	29	and	and	CCONJ
admet-2861	86	30	1.683	1.683	NUM
admet-2861	86	31	µm	µm	NOUN
admet-2861	86	32	in	in	ADP
admet-2861	86	33	product	product	NOUN
admet-2861	86	34	b3	b3	PROPN
admet-2861	86	35	.	.	PUNCT
admet-2861	87	1	this	this	PRON
admet-2861	87	2	,	,	PUNCT
admet-2861	87	3	along	along	ADP
admet-2861	87	4	with	with	ADP
admet-2861	87	5	the	the	DET
admet-2861	87	6	differences	difference	NOUN
admet-2861	87	7	in	in	ADP
admet-2861	87	8	geometric	geometric	ADJ
admet-2861	87	9	standard	standard	ADJ
admet-2861	87	10	deviation	deviation	NOUN
admet-2861	87	11	(	(	PUNCT
admet-2861	87	12	gsd	gsd	NOUN
admet-2861	87	13	)	)	PUNCT
admet-2861	87	14	,	,	PUNCT
admet-2861	87	15	aerodynamic	aerodynamic	ADJ
admet-2861	87	16	particle	particle	NOUN
admet-2861	87	17	size	size	NOUN
admet-2861	87	18	distribution	distribution	NOUN
admet-2861	87	19	(	(	PUNCT
admet-2861	87	20	figure	figure	NOUN
admet-2861	87	21	2	2	NUM
admet-2861	87	22	)	)	PUNCT
admet-2861	87	23	,	,	PUNCT
admet-2861	87	24	and	and	CCONJ
admet-2861	87	25	the	the	DET
admet-2861	87	26	resulting	result	VERB
admet-2861	87	27	dispersion	dispersion	NOUN
admet-2861	87	28	of	of	ADP
admet-2861	87	29	aerodynamic	aerodynamic	ADJ
admet-2861	87	30	particle	particle	NOUN
admet-2861	87	31	size	size	NOUN
admet-2861	87	32	,	,	PUNCT
admet-2861	87	33	suggests	suggest	VERB
admet-2861	87	34	potential	potential	ADJ
admet-2861	87	35	variations	variation	NOUN
admet-2861	87	36	in	in	ADP
admet-2861	87	37	the	the	DET
admet-2861	87	38	deposition	deposition	NOUN
admet-2861	87	39	of	of	ADP
admet-2861	87	40	drug	drug	NOUN
admet-2861	87	41	particles	particle	NOUN
admet-2861	87	42	in	in	ADP
admet-2861	87	43	the	the	DET
admet-2861	87	44	respiratory	respiratory	ADJ
admet-2861	87	45	tract	tract	NOUN
admet-2861	87	46	among	among	ADP
admet-2861	87	47	different	different	ADJ
admet-2861	87	48	inhalation	inhalation	NOUN
admet-2861	87	49	products	product	NOUN
admet-2861	87	50	.	.	PUNCT
admet-2861	88	1	https://www.simulations-plus.com/software/gastroplus/	https://www.simulations-plus.com/software/gastroplus/	PROPN
admet-2861	88	2	admet	admet	PROPN
admet-2861	88	3	&	&	CCONJ
admet-2861	88	4	dmpk	dmpk	PROPN
admet-2861	88	5	13	13	NUM
admet-2861	88	6	(	(	PUNCT
admet-2861	88	7	)	)	PUNCT
admet-2861	88	8	(	(	PUNCT
admet-2861	88	9	2025	2025	NUM
admet-2861	88	10	)	)	PUNCT
admet-2861	88	11	2861	2861	NUM
admet-2861	88	12	development	development	NOUN
admet-2861	88	13	of	of	ADP
admet-2861	88	14	a	a	DET
admet-2861	88	15	biorelevant	biorelevant	ADJ
admet-2861	88	16	dissolution	dissolution	NOUN
admet-2861	88	17	method	method	NOUN
admet-2861	88	18	for	for	ADP
admet-2861	88	19	inhalation	inhalation	NOUN
admet-2861	88	20	products	product	NOUN
admet-2861	88	21	doi	doi	NOUN
admet-2861	88	22	:	:	PUNCT
admet-2861	88	23	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	88	24	5	5	NUM
admet-2861	88	25	table	table	NOUN
admet-2861	88	26	1	1	NUM
admet-2861	88	27	.	.	PUNCT
admet-2861	88	28	overview	overview	NOUN
admet-2861	88	29	of	of	ADP
admet-2861	88	30	the	the	DET
admet-2861	88	31	composition	composition	NOUN
admet-2861	88	32	and	and	CCONJ
admet-2861	88	33	characteristics	characteristic	NOUN
admet-2861	88	34	of	of	ADP
admet-2861	88	35	the	the	DET
admet-2861	88	36	investigated	investigate	VERB
admet-2861	88	37	inhalation	inhalation	NOUN
admet-2861	88	38	products	product	NOUN
admet-2861	88	39	inhalation	inhalation	NOUN
admet-2861	88	40	product	product	NOUN
admet-2861	88	41	active	active	ADJ
admet-2861	88	42	substance	substance	NOUN
admet-2861	88	43	declared	declare	VERB
admet-2861	88	44	dose	dose	NOUN
admet-2861	88	45	,	,	PUNCT
admet-2861	88	46	µg	µg	ADV
admet-2861	88	47	propellant	propellant	NOUN
admet-2861	88	48	modifier	modifier	NOUN
admet-2861	88	49	active	active	ADJ
admet-2861	88	50	substance	substance	NOUN
admet-2861	88	51	2	2	NUM
admet-2861	88	52	mmad	mmad	NOUN
admet-2861	88	53	,	,	PUNCT
admet-2861	88	54	µm	µm	X
admet-2861	88	55	(	(	PUNCT
admet-2861	88	56	gsd	gsd	NOUN
admet-2861	88	57	)	)	PUNCT
admet-2861	88	58	fpf	fpf	NOUN
admet-2861	88	59	s1	s1	NOUN
admet-2861	88	60	*	*	PUNCT
admet-2861	88	61	salmeterol	salmeterol	NOUN
admet-2861	88	62	xinafoate	xinafoate	VERB
admet-2861	88	63	25	25	NUM
admet-2861	88	64	norflurane	norflurane	ADJ
admet-2861	88	65	fluticasone	fluticasone	NOUN
admet-2861	88	66	propionate	propionate	NOUN
admet-2861	88	67	3.042	3.042	NUM
admet-2861	88	68	(	(	PUNCT
admet-2861	88	69	2.154	2.154	NUM
admet-2861	88	70	)	)	PUNCT
admet-2861	88	71	0.53546	0.53546	NUM
admet-2861	88	72	s2	s2	PROPN
admet-2861	88	73	*	*	PROPN
admet-2861	88	74	25	25	NUM
admet-2861	88	75	norflurane	norflurane	PROPN
admet-2861	88	76	1.865	1.865	NUM
admet-2861	88	77	(	(	PUNCT
admet-2861	88	78	1.648	1.648	NUM
admet-2861	88	79	)	)	PUNCT
admet-2861	88	80	0.68932	0.68932	NUM
admet-2861	88	81	s3	s3	PROPN
admet-2861	88	82	*	*	PROPN
admet-2861	88	83	25	25	NUM
admet-2861	88	84	norflurane	norflurane	ADJ
admet-2861	88	85	fluticasone	fluticasone	NOUN
admet-2861	88	86	propionate	propionate	NOUN
admet-2861	88	87	3.415	3.415	NUM
admet-2861	88	88	(	(	PUNCT
admet-2861	88	89	1.669	1.669	NUM
admet-2861	88	90	)	)	PUNCT
admet-2861	88	91	0.40170	0.40170	NUM
admet-2861	88	92	s4	s4	NOUN
admet-2861	88	93	*	*	SYM
admet-2861	88	94	25	25	NUM
admet-2861	88	95	norflurane	norflurane	ADJ
admet-2861	88	96	anhydrous	anhydrous	ADJ
admet-2861	88	97	ethanol	ethanol	NOUN
admet-2861	88	98	,	,	PUNCT
admet-2861	88	99	soy	soy	NOUN
admet-2861	88	100	lecithin	lecithin	NOUN
admet-2861	88	101	1.535	1.535	NUM
admet-2861	88	102	(	(	PUNCT
admet-2861	88	103	1.493	1.493	NUM
admet-2861	88	104	)	)	PUNCT
admet-2861	88	105	0.49371	0.49371	NUM
admet-2861	89	1	b1	b1	NOUN
admet-2861	89	2	*	*	PUNCT
admet-2861	89	3	*	*	PUNCT
admet-2861	89	4	beclomethasone	beclomethasone	ADJ
admet-2861	89	5	dipropionate	dipropionate	NOUN
admet-2861	89	6	100	100	NUM
admet-2861	89	7	norflurane	norflurane	ADJ
admet-2861	89	8	ethanol	ethanol	NOUN
admet-2861	89	9	0.880	0.880	NUM
admet-2861	89	10	(	(	PUNCT
admet-2861	89	11	1.721	1.721	NUM
admet-2861	89	12	)	)	PUNCT
admet-2861	89	13	0.69888	0.69888	NUM
admet-2861	89	14	b2	b2	NOUN
admet-2861	89	15	*	*	PROPN
admet-2861	89	16	*	*	PROPN
admet-2861	89	17	100	100	NUM
admet-2861	89	18	norflurane	norflurane	ADJ
admet-2861	89	19	ethanol	ethanol	NOUN
admet-2861	89	20	formoterol	formoterol	NOUN
admet-2861	89	21	fumarate	fumarate	NOUN
admet-2861	89	22	1.028	1.028	NUM
admet-2861	89	23	(	(	PUNCT
admet-2861	89	24	1.881	1.881	NUM
admet-2861	89	25	)	)	PUNCT
admet-2861	89	26	0.57701	0.57701	NUM
admet-2861	89	27	b3	b3	NOUN
admet-2861	89	28	*	*	PUNCT
admet-2861	89	29	*	*	PROPN
admet-2861	89	30	250	250	NUM
admet-2861	89	31	norflurane	norflurane	ADJ
admet-2861	89	32	anhydrous	anhydrous	ADJ
admet-2861	89	33	ethanol	ethanol	NOUN
admet-2861	89	34	,	,	PUNCT
admet-2861	89	35	oleic	oleic	ADJ
admet-2861	89	36	acid	acid	PROPN
admet-2861	89	37	salbutamol	salbutamol	PROPN
admet-2861	89	38	sulphate	sulphate	VERB
admet-2861	89	39	1.683	1.683	NUM
admet-2861	89	40	(	(	PUNCT
admet-2861	89	41	2.097	2.097	NUM
admet-2861	89	42	)	)	PUNCT
admet-2861	89	43	0.56342	0.56342	NUM
admet-2861	89	44	*	*	PUNCT
admet-2861	89	45	s1	s1	PROPN
admet-2861	89	46	,	,	PUNCT
admet-2861	89	47	s2	s2	PROPN
admet-2861	89	48	,	,	PUNCT
admet-2861	89	49	s3	s3	PROPN
admet-2861	89	50	and	and	CCONJ
admet-2861	89	51	s4	s4	PROPN
admet-2861	89	52	–	–	PUNCT
admet-2861	89	53	commercial	commercial	ADJ
admet-2861	89	54	inhaler	inhaler	NOUN
admet-2861	89	55	products	product	NOUN
admet-2861	89	56	containing	contain	VERB
admet-2861	89	57	sx	sx	PROPN
admet-2861	89	58	,	,	PUNCT
admet-2861	89	59	*	*	PUNCT
admet-2861	89	60	*	*	PUNCT
admet-2861	89	61	b1	b1	NOUN
admet-2861	89	62	,	,	PUNCT
admet-2861	89	63	b2	b2	NOUN
admet-2861	89	64	and	and	CCONJ
admet-2861	89	65	b3	b3	PROPN
admet-2861	89	66	–	–	PUNCT
admet-2861	89	67	commercial	commercial	ADJ
admet-2861	89	68	inhaler	inhaler	NOUN
admet-2861	89	69	products	product	NOUN
admet-2861	89	70	containing	contain	VERB
admet-2861	89	71	bdp	bdp	PROPN
admet-2861	89	72	figure	figure	NOUN
admet-2861	89	73	2	2	NUM
admet-2861	89	74	.	.	PUNCT
admet-2861	89	75	distribution	distribution	NOUN
admet-2861	89	76	of	of	ADP
admet-2861	89	77	aerodynamic	aerodynamic	ADJ
admet-2861	89	78	size	size	NOUN
admet-2861	89	79	of	of	ADP
admet-2861	89	80	bdp	bdp	PROPN
admet-2861	89	81	particles	particle	NOUN
admet-2861	89	82	figure	figure	VERB
admet-2861	89	83	3	3	NUM
admet-2861	89	84	.	.	PUNCT
admet-2861	90	1	distribution	distribution	NOUN
admet-2861	90	2	of	of	ADP
admet-2861	90	3	aerodynamic	aerodynamic	ADJ
admet-2861	90	4	size	size	NOUN
admet-2861	90	5	of	of	ADP
admet-2861	90	6	sx	sx	PROPN
admet-2861	90	7	particles	particle	NOUN
admet-2861	90	8	the	the	DET
admet-2861	90	9	differences	difference	NOUN
admet-2861	90	10	in	in	ADP
admet-2861	90	11	mmad	mmad	NOUN
admet-2861	90	12	and	and	CCONJ
admet-2861	90	13	gsd	gsd	NOUN
admet-2861	90	14	were	be	AUX
admet-2861	90	15	more	more	ADV
admet-2861	90	16	pronounced	pronounce	VERB
admet-2861	90	17	in	in	ADP
admet-2861	90	18	sx	sx	PROPN
admet-2861	90	19	than	than	ADP
admet-2861	90	20	in	in	ADP
admet-2861	90	21	bdp	bdp	PROPN
admet-2861	90	22	products	product	NOUN
admet-2861	90	23	(	(	PUNCT
admet-2861	90	24	table	table	NOUN
admet-2861	90	25	1	1	NUM
admet-2861	90	26	)	)	PUNCT
admet-2861	90	27	.	.	PUNCT
admet-2861	91	1	based	base	VERB
admet-2861	91	2	on	on	ADP
admet-2861	91	3	the	the	DET
admet-2861	91	4	mmad	mmad	NOUN
admet-2861	91	5	values	value	NOUN
admet-2861	91	6	,	,	PUNCT
admet-2861	91	7	it	it	PRON
admet-2861	91	8	can	can	AUX
admet-2861	91	9	be	be	AUX
admet-2861	91	10	assumed	assume	VERB
admet-2861	91	11	that	that	SCONJ
admet-2861	91	12	sx	sx	PROPN
admet-2861	91	13	particles	particle	NOUN
admet-2861	91	14	will	will	AUX
admet-2861	91	15	be	be	AUX
admet-2861	91	16	deposited	deposit	VERB
admet-2861	91	17	in	in	ADP
admet-2861	91	18	the	the	DET
admet-2861	91	19	upper	upper	ADJ
admet-2861	91	20	parts	part	NOUN
admet-2861	91	21	of	of	ADP
admet-2861	91	22	the	the	DET
admet-2861	91	23	respiratory	respiratory	ADJ
admet-2861	91	24	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	92	1	a.	a.	NOUN
admet-2861	92	2	elezović	elezović	PROPN
admet-2861	92	3	et	et	PROPN
admet-2861	92	4	al	al	PROPN
admet-2861	92	5	.	.	PROPN
admet-2861	92	6	admet	admet	PROPN
admet-2861	92	7	&	&	CCONJ
admet-2861	92	8	dmpk	dmpk	PROPN
admet-2861	92	9	13(5	13(5	NUM
admet-2861	92	10	)	)	PUNCT
admet-2861	92	11	(	(	PUNCT
admet-2861	92	12	2025	2025	NUM
admet-2861	92	13	)	)	PUNCT
admet-2861	92	14	2861	2861	NUM
admet-2861	92	15	6	6	NUM
admet-2861	92	16	tract	tract	NOUN
admet-2861	92	17	,	,	PUNCT
admet-2861	92	18	and	and	CCONJ
admet-2861	92	19	the	the	DET
admet-2861	92	20	gsd	gsd	NOUN
admet-2861	92	21	values	value	NOUN
admet-2861	92	22	indicate	indicate	VERB
admet-2861	92	23	that	that	SCONJ
admet-2861	92	24	the	the	DET
admet-2861	92	25	differences	difference	NOUN
admet-2861	92	26	in	in	ADP
admet-2861	92	27	the	the	DET
admet-2861	92	28	“	"	PUNCT
admet-2861	92	29	width	width	NOUN
admet-2861	92	30	”	"	PUNCT
admet-2861	92	31	of	of	ADP
admet-2861	92	32	the	the	DET
admet-2861	92	33	distribution	distribution	NOUN
admet-2861	92	34	between	between	ADP
admet-2861	92	35	the	the	DET
admet-2861	92	36	four	four	NUM
admet-2861	92	37	tested	test	VERB
admet-2861	92	38	products	product	NOUN
admet-2861	92	39	will	will	AUX
admet-2861	92	40	be	be	AUX
admet-2861	92	41	more	more	ADV
admet-2861	92	42	significant	significant	ADJ
admet-2861	92	43	than	than	ADP
admet-2861	92	44	the	the	DET
admet-2861	92	45	differences	difference	NOUN
admet-2861	92	46	among	among	ADP
admet-2861	92	47	the	the	DET
admet-2861	92	48	products	product	NOUN
admet-2861	92	49	containing	contain	VERB
admet-2861	92	50	bdp	bdp	PROPN
admet-2861	92	51	.	.	PUNCT
admet-2861	93	1	in	in	ADP
admet-2861	93	2	contrast	contrast	NOUN
admet-2861	93	3	to	to	ADP
admet-2861	93	4	the	the	DET
admet-2861	93	5	products	product	NOUN
admet-2861	93	6	containing	contain	VERB
admet-2861	93	7	bdp	bdp	PROPN
admet-2861	93	8	,	,	PUNCT
admet-2861	93	9	all	all	DET
admet-2861	93	10	four	four	NUM
admet-2861	93	11	sx	sx	NOUN
admet-2861	93	12	products	product	NOUN
admet-2861	93	13	had	have	VERB
admet-2861	93	14	the	the	DET
admet-2861	93	15	same	same	ADJ
admet-2861	93	16	declared	declare	VERB
admet-2861	93	17	content	content	NOUN
admet-2861	93	18	value	value	NOUN
admet-2861	93	19	per	per	ADP
admet-2861	93	20	dose	dose	NOUN
admet-2861	93	21	(	(	PUNCT
admet-2861	93	22	25	25	NUM
admet-2861	93	23	µg	µg	NOUN
admet-2861	93	24	)	)	PUNCT
admet-2861	93	25	.	.	PUNCT
admet-2861	94	1	still	still	ADV
admet-2861	94	2	,	,	PUNCT
admet-2861	94	3	the	the	DET
admet-2861	94	4	differences	difference	NOUN
admet-2861	94	5	in	in	ADP
admet-2861	94	6	fpf	fpf	NOUN
admet-2861	94	7	were	be	AUX
admet-2861	94	8	more	more	ADV
admet-2861	94	9	pronounced	pronounced	ADJ
admet-2861	94	10	.	.	PUNCT
admet-2861	95	1	the	the	DET
admet-2861	95	2	results	result	NOUN
admet-2861	95	3	of	of	ADP
admet-2861	95	4	the	the	DET
admet-2861	95	5	aerodynamic	aerodynamic	ADJ
admet-2861	95	6	assessment	assessment	NOUN
admet-2861	95	7	of	of	ADP
admet-2861	95	8	fine	fine	ADJ
admet-2861	95	9	particles	particle	NOUN
admet-2861	95	10	,	,	PUNCT
admet-2861	95	11	according	accord	VERB
admet-2861	95	12	to	to	ADP
admet-2861	95	13	the	the	DET
admet-2861	95	14	ema	ema	PROPN
admet-2861	95	15	guideline	guideline	NOUN
admet-2861	95	16	[	[	X
admet-2861	95	17	34	34	NUM
admet-2861	95	18	]	]	PUNCT
admet-2861	95	19	,	,	PUNCT
admet-2861	95	20	indicate	indicate	VERB
admet-2861	95	21	that	that	SCONJ
admet-2861	95	22	the	the	DET
admet-2861	95	23	tested	test	VERB
admet-2861	95	24	products	product	NOUN
admet-2861	95	25	would	would	AUX
admet-2861	95	26	not	not	PART
admet-2861	95	27	be	be	AUX
admet-2861	95	28	equivalent	equivalent	ADJ
admet-2861	95	29	.	.	PUNCT
admet-2861	96	1	in	in	ADP
admet-2861	96	2	the	the	DET
admet-2861	96	3	development	development	NOUN
admet-2861	96	4	of	of	ADP
admet-2861	96	5	a	a	DET
admet-2861	96	6	biorelevant	biorelevant	NOUN
admet-2861	96	7	method	method	NOUN
admet-2861	96	8	for	for	ADP
admet-2861	96	9	drug	drug	NOUN
admet-2861	96	10	dissolution	dissolution	NOUN
admet-2861	96	11	from	from	ADP
admet-2861	96	12	a	a	DET
admet-2861	96	13	preparation	preparation	NOUN
admet-2861	96	14	for	for	ADP
admet-2861	96	15	inhalation	inhalation	NOUN
admet-2861	96	16	,	,	PUNCT
admet-2861	96	17	the	the	DET
admet-2861	96	18	following	follow	VERB
admet-2861	96	19	critical	critical	ADJ
admet-2861	96	20	factors	factor	NOUN
admet-2861	96	21	affecting	affect	VERB
admet-2861	96	22	drug	drug	NOUN
admet-2861	96	23	dissolution	dissolution	NOUN
admet-2861	96	24	rate	rate	NOUN
admet-2861	96	25	were	be	AUX
admet-2861	96	26	carefully	carefully	ADV
admet-2861	96	27	considered	consider	VERB
admet-2861	96	28	:	:	PUNCT
admet-2861	96	29	(	(	PUNCT
admet-2861	96	30	a	a	X
admet-2861	96	31	)	)	PUNCT
admet-2861	96	32	aerodynamic	aerodynamic	ADJ
admet-2861	96	33	particle	particle	NOUN
admet-2861	96	34	size	size	NOUN
admet-2861	96	35	distribution	distribution	NOUN
admet-2861	96	36	and	and	CCONJ
admet-2861	96	37	the	the	DET
admet-2861	96	38	proportion	proportion	NOUN
admet-2861	96	39	of	of	ADP
admet-2861	96	40	the	the	DET
admet-2861	96	41	respirable	respirable	ADJ
admet-2861	96	42	fraction	fraction	NOUN
admet-2861	96	43	of	of	ADP
admet-2861	96	44	the	the	DET
admet-2861	96	45	drug	drug	NOUN
admet-2861	96	46	;	;	PUNCT
admet-2861	96	47	(	(	PUNCT
admet-2861	96	48	b	b	X
admet-2861	96	49	)	)	PUNCT
admet-2861	96	50	type	type	NOUN
admet-2861	96	51	and	and	CCONJ
admet-2861	96	52	volume	volume	NOUN
admet-2861	96	53	of	of	ADP
admet-2861	96	54	the	the	DET
admet-2861	96	55	test	test	NOUN
admet-2861	96	56	medium	medium	NOUN
admet-2861	96	57	;	;	PUNCT
admet-2861	96	58	(	(	PUNCT
admet-2861	96	59	c	c	X
admet-2861	96	60	)	)	PUNCT
admet-2861	96	61	solubility	solubility	NOUN
admet-2861	96	62	of	of	ADP
admet-2861	96	63	the	the	DET
admet-2861	96	64	drug	drug	NOUN
admet-2861	96	65	substance	substance	NOUN
admet-2861	96	66	in	in	ADP
admet-2861	96	67	dissolution	dissolution	ADJ
admet-2861	96	68	medium	medium	NOUN
admet-2861	96	69	;	;	PUNCT
admet-2861	96	70	(	(	PUNCT
admet-2861	96	71	d	d	X
admet-2861	96	72	)	)	PUNCT
admet-2861	96	73	characteristics	characteristic	NOUN
admet-2861	96	74	of	of	ADP
admet-2861	96	75	the	the	DET
admet-2861	96	76	membrane	membrane	NOUN
admet-2861	96	77	through	through	ADP
admet-2861	96	78	which	which	PRON
admet-2861	96	79	the	the	DET
admet-2861	96	80	substance	substance	NOUN
admet-2861	96	81	is	be	AUX
admet-2861	96	82	absorbed	absorb	VERB
admet-2861	96	83	;	;	PUNCT
admet-2861	96	84	(	(	PUNCT
admet-2861	96	85	e	e	NOUN
admet-2861	96	86	)	)	PUNCT
admet-2861	96	87	device	device	NOUN
admet-2861	96	88	design	design	NOUN
admet-2861	96	89	;	;	PUNCT
admet-2861	96	90	and	and	CCONJ
admet-2861	96	91	(	(	PUNCT
admet-2861	96	92	f	f	X
admet-2861	96	93	)	)	PUNCT
admet-2861	96	94	paddle	paddle	NOUN
admet-2861	96	95	stirring	stirring	NOUN
admet-2861	96	96	rate	rate	NOUN
admet-2861	96	97	during	during	ADP
admet-2861	96	98	the	the	DET
admet-2861	96	99	analysis	analysis	NOUN
admet-2861	96	100	.	.	PUNCT
admet-2861	97	1	in	in	ADP
admet-2861	97	2	the	the	DET
admet-2861	97	3	published	publish	VERB
admet-2861	97	4	papers	paper	NOUN
admet-2861	97	5	dealing	deal	VERB
admet-2861	97	6	with	with	ADP
admet-2861	97	7	dissolution	dissolution	NOUN
admet-2861	97	8	method	method	NOUN
admet-2861	97	9	development	development	NOUN
admet-2861	97	10	for	for	ADP
admet-2861	97	11	inhalation	inhalation	NOUN
admet-2861	97	12	products	product	NOUN
admet-2861	97	13	[	[	PUNCT
admet-2861	97	14	9	9	NUM
admet-2861	97	15	-	-	SYM
admet-2861	97	16	11,14	11,14	NUM
admet-2861	97	17	,	,	PUNCT
admet-2861	97	18	15,17	15,17	NUM
admet-2861	97	19	-	-	PUNCT
admet-2861	97	20	21,23	21,23	NUM
admet-2861	97	21	]	]	PUNCT
admet-2861	97	22	,	,	PUNCT
admet-2861	97	23	two	two	NUM
admet-2861	97	24	approaches	approach	NOUN
admet-2861	97	25	for	for	ADP
admet-2861	97	26	sample	sample	NOUN
admet-2861	97	27	collection	collection	NOUN
admet-2861	97	28	are	be	AUX
admet-2861	97	29	described	describe	VERB
admet-2861	97	30	:	:	PUNCT
admet-2861	97	31	with	with	ADP
admet-2861	97	32	or	or	CCONJ
admet-2861	97	33	without	without	ADP
admet-2861	97	34	separation	separation	NOUN
admet-2861	97	35	of	of	ADP
admet-2861	97	36	particles	particle	NOUN
admet-2861	97	37	based	base	VERB
admet-2861	97	38	on	on	ADP
admet-2861	97	39	their	their	PRON
admet-2861	97	40	aerodynamic	aerodynamic	ADJ
admet-2861	97	41	diameter	diameter	NOUN
admet-2861	97	42	.	.	PUNCT
admet-2861	98	1	sampling	sample	VERB
admet-2861	98	2	without	without	ADP
admet-2861	98	3	particle	particle	NOUN
admet-2861	98	4	size	size	NOUN
admet-2861	98	5	separation	separation	NOUN
admet-2861	98	6	is	be	AUX
admet-2861	98	7	more	more	ADV
admet-2861	98	8	straightforward	straightforward	ADJ
admet-2861	98	9	and	and	CCONJ
admet-2861	98	10	faster	fast	ADV
admet-2861	98	11	.	.	PUNCT
admet-2861	99	1	however	however	ADV
admet-2861	99	2	,	,	PUNCT
admet-2861	99	3	such	such	DET
admet-2861	99	4	a	a	DET
admet-2861	99	5	sample	sample	NOUN
admet-2861	99	6	does	do	AUX
admet-2861	99	7	not	not	PART
admet-2861	99	8	represent	represent	VERB
admet-2861	99	9	a	a	DET
admet-2861	99	10	situation	situation	NOUN
admet-2861	99	11	equivalent	equivalent	ADJ
admet-2861	99	12	to	to	ADP
admet-2861	99	13	what	what	PRON
admet-2861	99	14	happens	happen	VERB
admet-2861	99	15	in	in	ADP
admet-2861	99	16	vivo	vivo	NOUN
admet-2861	99	17	.	.	PUNCT
admet-2861	100	1	therefore	therefore	ADV
admet-2861	100	2	,	,	PUNCT
admet-2861	100	3	the	the	DET
admet-2861	100	4	dissolution	dissolution	NOUN
admet-2861	100	5	testing	testing	NOUN
admet-2861	100	6	of	of	ADP
admet-2861	100	7	samples	sample	NOUN
admet-2861	100	8	that	that	PRON
admet-2861	100	9	are	be	AUX
admet-2861	100	10	not	not	PART
admet-2861	100	11	separated	separate	VERB
admet-2861	100	12	into	into	ADP
admet-2861	100	13	fine	fine	ADJ
admet-2861	100	14	and	and	CCONJ
admet-2861	100	15	coarse	coarse	ADJ
admet-2861	100	16	fractions	fraction	NOUN
admet-2861	100	17	may	may	AUX
admet-2861	100	18	lead	lead	VERB
admet-2861	100	19	to	to	ADP
admet-2861	100	20	results	result	NOUN
admet-2861	100	21	that	that	PRON
admet-2861	100	22	do	do	AUX
admet-2861	100	23	not	not	PART
admet-2861	100	24	accurately	accurately	ADV
admet-2861	100	25	correspond	correspond	VERB
admet-2861	100	26	to	to	ADP
admet-2861	100	27	the	the	DET
admet-2861	100	28	in	in	ADP
admet-2861	100	29	vivo	vivo	ADJ
admet-2861	100	30	situation	situation	NOUN
admet-2861	100	31	.	.	PUNCT
admet-2861	101	1	this	this	PRON
admet-2861	101	2	is	be	AUX
admet-2861	101	3	particularly	particularly	ADV
admet-2861	101	4	true	true	ADJ
admet-2861	101	5	for	for	ADP
admet-2861	101	6	dry	dry	ADJ
admet-2861	101	7	powder	powder	NOUN
admet-2861	101	8	inhaler	inhaler	NOUN
admet-2861	101	9	(	(	PUNCT
admet-2861	101	10	dpi	dpi	NOUN
admet-2861	101	11	)	)	PUNCT
admet-2861	101	12	products	product	NOUN
admet-2861	101	13	with	with	ADP
admet-2861	101	14	a	a	DET
admet-2861	101	15	higher	high	ADJ
admet-2861	101	16	proportion	proportion	NOUN
admet-2861	101	17	of	of	ADP
admet-2861	101	18	large	large	ADJ
admet-2861	101	19	particles	particle	NOUN
admet-2861	101	20	,	,	PUNCT
admet-2861	101	21	which	which	PRON
admet-2861	101	22	may	may	AUX
admet-2861	101	23	be	be	AUX
admet-2861	101	24	retained	retain	VERB
admet-2861	101	25	in	in	ADP
admet-2861	101	26	the	the	DET
admet-2861	101	27	mouth	mouth	NOUN
admet-2861	101	28	and	and	CCONJ
admet-2861	101	29	pharynx	pharynx	NOUN
admet-2861	101	30	.	.	PUNCT
admet-2861	102	1	drug	drug	NOUN
admet-2861	102	2	particles	particle	NOUN
admet-2861	102	3	deposited	deposit	VERB
admet-2861	102	4	in	in	ADP
admet-2861	102	5	these	these	DET
admet-2861	102	6	regions	region	NOUN
admet-2861	102	7	are	be	AUX
admet-2861	102	8	likely	likely	ADJ
admet-2861	102	9	to	to	PART
admet-2861	102	10	be	be	AUX
admet-2861	102	11	swallowed	swallow	VERB
admet-2861	102	12	,	,	PUNCT
admet-2861	102	13	dissolved	dissolve	VERB
admet-2861	102	14	,	,	PUNCT
admet-2861	102	15	absorbed	absorb	VERB
admet-2861	102	16	,	,	PUNCT
admet-2861	102	17	and	and	CCONJ
admet-2861	102	18	metabolized	metabolize	VERB
admet-2861	102	19	as	as	ADP
admet-2861	102	20	in	in	ADP
admet-2861	102	21	the	the	DET
admet-2861	102	22	case	case	NOUN
admet-2861	102	23	of	of	ADP
admet-2861	102	24	oral	oral	ADJ
admet-2861	102	25	preparation	preparation	NOUN
admet-2861	102	26	.	.	PUNCT
admet-2861	103	1	considering	consider	VERB
admet-2861	103	2	notable	notable	ADJ
admet-2861	103	3	differences	difference	NOUN
admet-2861	103	4	in	in	ADP
admet-2861	103	5	drug	drug	NOUN
admet-2861	103	6	absorption	absorption	NOUN
admet-2861	103	7	and	and	CCONJ
admet-2861	103	8	elimination	elimination	NOUN
admet-2861	103	9	between	between	ADP
admet-2861	103	10	oral	oral	ADJ
admet-2861	103	11	and	and	CCONJ
admet-2861	103	12	inhalation	inhalation	NOUN
admet-2861	103	13	routes	route	NOUN
admet-2861	103	14	of	of	ADP
admet-2861	103	15	administration	administration	NOUN
admet-2861	103	16	,	,	PUNCT
admet-2861	103	17	it	it	PRON
admet-2861	103	18	may	may	AUX
admet-2861	103	19	be	be	AUX
admet-2861	103	20	argued	argue	VERB
admet-2861	103	21	that	that	SCONJ
admet-2861	103	22	data	datum	NOUN
admet-2861	103	23	on	on	ADP
admet-2861	103	24	the	the	DET
admet-2861	103	25	dissolution	dissolution	NOUN
admet-2861	103	26	of	of	ADP
admet-2861	103	27	large	large	ADJ
admet-2861	103	28	particles	particle	NOUN
admet-2861	103	29	does	do	AUX
admet-2861	103	30	not	not	PART
admet-2861	103	31	provide	provide	VERB
admet-2861	103	32	an	an	DET
admet-2861	103	33	accurate	accurate	ADJ
admet-2861	103	34	estimate	estimate	NOUN
admet-2861	103	35	of	of	ADP
admet-2861	103	36	the	the	DET
admet-2861	103	37	inhalation	inhalation	NOUN
admet-2861	103	38	product	product	NOUN
admet-2861	103	39	's	's	PART
admet-2861	103	40	bioperformance	bioperformance	NOUN
admet-2861	103	41	.	.	PUNCT
admet-2861	104	1	accordingly	accordingly	ADV
admet-2861	104	2	,	,	PUNCT
admet-2861	104	3	samples	sample	NOUN
admet-2861	104	4	consisting	consist	VERB
admet-2861	104	5	of	of	ADP
admet-2861	104	6	the	the	DET
admet-2861	104	7	fine	fine	ADJ
admet-2861	104	8	particle	particle	NOUN
admet-2861	104	9	fraction	fraction	NOUN
admet-2861	104	10	,	,	PUNCT
admet-2861	104	11	which	which	PRON
admet-2861	104	12	was	be	AUX
admet-2861	104	13	considered	consider	VERB
admet-2861	104	14	to	to	PART
admet-2861	104	15	be	be	AUX
admet-2861	104	16	deposited	deposit	VERB
admet-2861	104	17	in	in	ADP
admet-2861	104	18	the	the	DET
admet-2861	104	19	lower	low	ADJ
admet-2861	104	20	parts	part	NOUN
admet-2861	104	21	of	of	ADP
admet-2861	104	22	the	the	DET
admet-2861	104	23	respiratory	respiratory	ADJ
admet-2861	104	24	tract	tract	NOUN
admet-2861	104	25	,	,	PUNCT
admet-2861	104	26	were	be	AUX
admet-2861	104	27	used	use	VERB
admet-2861	104	28	for	for	ADP
admet-2861	104	29	dissolution	dissolution	NOUN
admet-2861	104	30	testing	testing	NOUN
admet-2861	104	31	.	.	PUNCT
admet-2861	105	1	this	this	DET
admet-2861	105	2	fraction	fraction	NOUN
admet-2861	105	3	is	be	AUX
admet-2861	105	4	considered	consider	VERB
admet-2861	105	5	to	to	PART
admet-2861	105	6	consist	consist	VERB
admet-2861	105	7	of	of	ADP
admet-2861	105	8	particles	particle	NOUN
admet-2861	105	9	smaller	small	ADJ
admet-2861	105	10	than	than	ADP
admet-2861	105	11	5	5	NUM
admet-2861	105	12	µm	µm	NOUN
admet-2861	105	13	.	.	PUNCT
admet-2861	106	1	however	however	ADV
admet-2861	106	2	,	,	PUNCT
admet-2861	106	3	particles	particle	NOUN
admet-2861	106	4	smaller	small	ADJ
admet-2861	106	5	than	than	ADP
admet-2861	106	6	1	1	NUM
admet-2861	106	7	µm	µm	NUM
admet-2861	106	8	are	be	AUX
admet-2861	106	9	often	often	ADV
admet-2861	106	10	not	not	PART
admet-2861	106	11	included	include	VERB
admet-2861	106	12	in	in	ADP
admet-2861	106	13	this	this	DET
admet-2861	106	14	fraction	fraction	NOUN
admet-2861	106	15	because	because	SCONJ
admet-2861	106	16	they	they	PRON
admet-2861	106	17	are	be	AUX
admet-2861	106	18	considered	consider	VERB
admet-2861	106	19	too	too	ADV
admet-2861	106	20	small	small	ADJ
admet-2861	106	21	to	to	PART
admet-2861	106	22	be	be	AUX
admet-2861	106	23	retained	retain	VERB
admet-2861	106	24	in	in	ADP
admet-2861	106	25	the	the	DET
admet-2861	106	26	lungs	lung	NOUN
admet-2861	106	27	and	and	CCONJ
admet-2861	106	28	are	be	AUX
admet-2861	106	29	mostly	mostly	ADV
admet-2861	106	30	expelled	expel	VERB
admet-2861	106	31	from	from	ADP
admet-2861	106	32	the	the	DET
admet-2861	106	33	lungs	lung	NOUN
admet-2861	106	34	through	through	ADP
admet-2861	106	35	exhalation	exhalation	NOUN
admet-2861	106	36	[	[	X
admet-2861	106	37	35	35	NUM
admet-2861	106	38	]	]	PUNCT
admet-2861	106	39	.	.	PUNCT
admet-2861	107	1	the	the	DET
admet-2861	107	2	aci	aci	PROPN
admet-2861	107	3	does	do	AUX
admet-2861	107	4	not	not	PART
admet-2861	107	5	have	have	VERB
admet-2861	107	6	stages	stage	NOUN
admet-2861	107	7	that	that	PRON
admet-2861	107	8	correspond	correspond	VERB
admet-2861	107	9	precisely	precisely	ADV
admet-2861	107	10	to	to	ADP
admet-2861	107	11	these	these	DET
admet-2861	107	12	diameters	diameter	NOUN
admet-2861	107	13	.	.	PUNCT
admet-2861	108	1	the	the	DET
admet-2861	108	2	closest	close	ADJ
admet-2861	108	3	stages	stage	NOUN
admet-2861	108	4	are	be	AUX
admet-2861	108	5	stage	stage	NOUN
admet-2861	108	6	2	2	NUM
admet-2861	108	7	,	,	PUNCT
admet-2861	108	8	with	with	ADP
admet-2861	108	9	a	a	DET
admet-2861	108	10	cut	cut	VERB
admet-2861	108	11	-	-	PUNCT
admet-2861	108	12	off	off	ADP
admet-2861	108	13	value	value	NOUN
admet-2861	108	14	of	of	ADP
admet-2861	108	15	4.7	4.7	NUM
admet-2861	108	16	µm	µm	NOUN
admet-2861	108	17	,	,	PUNCT
admet-2861	108	18	and	and	CCONJ
admet-2861	108	19	stage	stage	NOUN
admet-2861	108	20	7	7	NUM
admet-2861	108	21	,	,	PUNCT
admet-2861	108	22	with	with	ADP
admet-2861	108	23	a	a	DET
admet-2861	108	24	cut	cut	VERB
admet-2861	108	25	-	-	PUNCT
admet-2861	108	26	off	off	ADP
admet-2861	108	27	value	value	NOUN
admet-2861	108	28	of	of	ADP
admet-2861	108	29	0.7	0.7	NUM
admet-2861	108	30	µm	µm	NOUN
admet-2861	108	31	.	.	PUNCT
admet-2861	109	1	therefore	therefore	ADV
admet-2861	109	2	,	,	PUNCT
admet-2861	109	3	the	the	DET
admet-2861	109	4	aci	aci	PROPN
admet-2861	109	5	was	be	AUX
admet-2861	109	6	assembled	assemble	VERB
admet-2861	109	7	in	in	ADP
admet-2861	109	8	an	an	DET
admet-2861	109	9	abbreviated	abbreviate	VERB
admet-2861	109	10	version	version	NOUN
admet-2861	109	11	(	(	PUNCT
admet-2861	109	12	aaci	aaci	NOUN
admet-2861	109	13	)	)	PUNCT
admet-2861	109	14	,	,	PUNCT
admet-2861	109	15	with	with	ADP
admet-2861	109	16	the	the	DET
admet-2861	109	17	stages	stage	NOUN
admet-2861	109	18	in	in	ADP
admet-2861	109	19	the	the	DET
admet-2861	109	20	following	follow	VERB
admet-2861	109	21	order	order	NOUN
admet-2861	109	22	:	:	PUNCT
admet-2861	109	23	0	0	NUM
admet-2861	109	24	,	,	PUNCT
admet-2861	109	25	1	1	NUM
admet-2861	109	26	,	,	PUNCT
admet-2861	109	27	2	2	NUM
admet-2861	109	28	,	,	PUNCT
admet-2861	109	29	7	7	NUM
admet-2861	109	30	,	,	PUNCT
admet-2861	109	31	and	and	CCONJ
admet-2861	109	32	the	the	DET
admet-2861	109	33	filter	filter	NOUN
admet-2861	109	34	stage	stage	NOUN
admet-2861	109	35	.	.	PUNCT
admet-2861	110	1	this	this	DET
admet-2861	110	2	setup	setup	NOUN
admet-2861	110	3	allows	allow	VERB
admet-2861	110	4	particles	particle	NOUN
admet-2861	110	5	in	in	ADP
admet-2861	110	6	the	the	DET
admet-2861	110	7	aerodynamic	aerodynamic	ADJ
admet-2861	110	8	diameter	diameter	NOUN
admet-2861	110	9	range	range	NOUN
admet-2861	110	10	of	of	ADP
admet-2861	110	11	4.7	4.7	NUM
admet-2861	110	12	to	to	PART
admet-2861	110	13	0.7	0.7	NUM
admet-2861	110	14	µm	µm	NOUN
admet-2861	110	15	to	to	PART
admet-2861	110	16	be	be	AUX
admet-2861	110	17	retained	retain	VERB
admet-2861	110	18	on	on	ADP
admet-2861	110	19	the	the	DET
admet-2861	110	20	surface	surface	NOUN
admet-2861	110	21	of	of	ADP
admet-2861	110	22	the	the	DET
admet-2861	110	23	plate	plate	NOUN
admet-2861	110	24	below	below	ADP
admet-2861	110	25	stage	stage	NOUN
admet-2861	110	26	7	7	NUM
admet-2861	110	27	.	.	PUNCT
admet-2861	111	1	this	this	DET
admet-2861	111	2	range	range	NOUN
admet-2861	111	3	corresponds	correspond	VERB
admet-2861	111	4	to	to	ADP
admet-2861	111	5	the	the	DET
admet-2861	111	6	particle	particle	NOUN
admet-2861	111	7	size	size	NOUN
admet-2861	111	8	values	value	NOUN
admet-2861	111	9	that	that	PRON
admet-2861	111	10	are	be	AUX
admet-2861	111	11	thought	think	VERB
admet-2861	111	12	to	to	PART
admet-2861	111	13	be	be	AUX
admet-2861	111	14	deposited	deposit	VERB
admet-2861	111	15	and	and	CCONJ
admet-2861	111	16	absorbed	absorb	VERB
admet-2861	111	17	in	in	ADP
admet-2861	111	18	the	the	DET
admet-2861	111	19	lower	low	ADJ
admet-2861	111	20	respiratory	respiratory	ADJ
admet-2861	111	21	tract	tract	NOUN
admet-2861	111	22	.	.	PUNCT
admet-2861	112	1	to	to	PART
admet-2861	112	2	calculate	calculate	VERB
admet-2861	112	3	the	the	DET
admet-2861	112	4	fraction	fraction	NOUN
admet-2861	112	5	of	of	ADP
admet-2861	112	6	the	the	DET
admet-2861	112	7	dissolved	dissolve	VERB
admet-2861	112	8	drug	drug	NOUN
admet-2861	112	9	,	,	PUNCT
admet-2861	112	10	it	it	PRON
admet-2861	112	11	is	be	AUX
admet-2861	112	12	necessary	necessary	ADJ
admet-2861	112	13	to	to	PART
admet-2861	112	14	know	know	VERB
admet-2861	112	15	the	the	DET
admet-2861	112	16	amount	amount	NOUN
admet-2861	112	17	of	of	ADP
admet-2861	112	18	drug	drug	NOUN
admet-2861	112	19	available	available	ADJ
admet-2861	112	20	for	for	ADP
admet-2861	112	21	dissolution	dissolution	NOUN
admet-2861	112	22	.	.	PUNCT
admet-2861	113	1	this	this	DET
admet-2861	113	2	information	information	NOUN
admet-2861	113	3	is	be	AUX
admet-2861	113	4	readily	readily	ADV
admet-2861	113	5	available	available	ADJ
admet-2861	113	6	in	in	ADP
admet-2861	113	7	the	the	DET
admet-2861	113	8	case	case	NOUN
admet-2861	113	9	of	of	ADP
admet-2861	113	10	oral	oral	ADJ
admet-2861	113	11	products	product	NOUN
admet-2861	113	12	the	the	DET
admet-2861	113	13	entire	entire	ADJ
admet-2861	113	14	administered/	administered/	PROPN
admet-2861	113	15	/declared	/declared	ADJ
admet-2861	113	16	dose	dose	NOUN
admet-2861	113	17	is	be	AUX
admet-2861	113	18	available	available	ADJ
admet-2861	113	19	for	for	ADP
admet-2861	113	20	dissolution	dissolution	NOUN
admet-2861	113	21	and	and	CCONJ
admet-2861	113	22	subsequent	subsequent	ADJ
admet-2861	113	23	absorption	absorption	NOUN
admet-2861	113	24	.	.	PUNCT
admet-2861	114	1	the	the	DET
admet-2861	114	2	situation	situation	NOUN
admet-2861	114	3	with	with	ADP
admet-2861	114	4	preparations	preparation	NOUN
admet-2861	114	5	for	for	ADP
admet-2861	114	6	inhalation	inhalation	NOUN
admet-2861	114	7	is	be	AUX
admet-2861	114	8	much	much	ADV
admet-2861	114	9	more	more	ADV
admet-2861	114	10	complicated	complicated	ADJ
admet-2861	114	11	.	.	PUNCT
admet-2861	115	1	while	while	SCONJ
admet-2861	115	2	one	one	NUM
admet-2861	115	3	of	of	ADP
admet-2861	115	4	the	the	DET
admet-2861	115	5	primary	primary	ADJ
admet-2861	115	6	physiological	physiological	ADJ
admet-2861	115	7	functions	function	NOUN
admet-2861	115	8	of	of	ADP
admet-2861	115	9	the	the	DET
admet-2861	115	10	gastrointestinal	gastrointestinal	ADJ
admet-2861	115	11	system	system	NOUN
admet-2861	115	12	is	be	AUX
admet-2861	115	13	the	the	DET
admet-2861	115	14	transfer	transfer	NOUN
admet-2861	115	15	of	of	ADP
admet-2861	115	16	nutrients	nutrient	NOUN
admet-2861	115	17	,	,	PUNCT
admet-2861	115	18	water	water	NOUN
admet-2861	115	19	,	,	PUNCT
admet-2861	115	20	and	and	CCONJ
admet-2861	115	21	electrolytes	electrolyte	NOUN
admet-2861	115	22	from	from	ADP
admet-2861	115	23	the	the	DET
admet-2861	115	24	digestive	digestive	ADJ
admet-2861	115	25	tract	tract	NOUN
admet-2861	115	26	into	into	ADP
admet-2861	115	27	the	the	DET
admet-2861	115	28	bloodstream	bloodstream	NOUN
admet-2861	115	29	(	(	PUNCT
admet-2861	115	30	i.e.	i.e.	X
admet-2861	115	31	absorption	absorption	NOUN
admet-2861	115	32	)	)	PUNCT
admet-2861	115	33	,	,	PUNCT
admet-2861	115	34	the	the	DET
admet-2861	115	35	respiratory	respiratory	ADJ
admet-2861	115	36	system	system	NOUN
admet-2861	115	37	's	's	PART
admet-2861	115	38	role	role	NOUN
admet-2861	115	39	is	be	AUX
admet-2861	115	40	to	to	PART
admet-2861	115	41	prevent	prevent	VERB
admet-2861	115	42	penetration	penetration	NOUN
admet-2861	115	43	and	and	CCONJ
admet-2861	115	44	accelerate	accelerate	VERB
admet-2861	115	45	the	the	DET
admet-2861	115	46	removal	removal	NOUN
admet-2861	115	47	of	of	ADP
admet-2861	115	48	airborne	airborne	ADJ
admet-2861	115	49	particles	particle	NOUN
admet-2861	115	50	.	.	PUNCT
admet-2861	116	1	specific	specific	ADJ
admet-2861	116	2	pharmaceutical	pharmaceutical	NOUN
admet-2861	116	3	-	-	PUNCT
admet-2861	116	4	technological	technological	ADJ
admet-2861	116	5	solutions	solution	NOUN
admet-2861	116	6	to	to	ADP
admet-2861	116	7	these	these	DET
admet-2861	116	8	problems	problem	NOUN
admet-2861	116	9	lead	lead	VERB
admet-2861	116	10	to	to	ADP
admet-2861	116	11	a	a	DET
admet-2861	116	12	discrepancy	discrepancy	NOUN
admet-2861	116	13	between	between	ADP
admet-2861	116	14	the	the	DET
admet-2861	116	15	declared	declare	VERB
admet-2861	116	16	dose	dose	NOUN
admet-2861	116	17	and	and	CCONJ
admet-2861	116	18	the	the	DET
admet-2861	116	19	amount	amount	NOUN
admet-2861	116	20	of	of	ADP
admet-2861	116	21	drug	drug	NOUN
admet-2861	116	22	available	available	ADJ
admet-2861	116	23	for	for	ADP
admet-2861	116	24	dissolution	dissolution	NOUN
admet-2861	116	25	and	and	CCONJ
admet-2861	116	26	absorption	absorption	NOUN
admet-2861	116	27	.	.	PUNCT
admet-2861	117	1	the	the	DET
admet-2861	117	2	declared	declare	VERB
admet-2861	117	3	dose	dose	NOUN
admet-2861	117	4	is	be	AUX
admet-2861	117	5	a	a	DET
admet-2861	117	6	theoretical	theoretical	ADJ
admet-2861	117	7	dose	dose	NOUN
admet-2861	117	8	that	that	PRON
admet-2861	117	9	has	have	AUX
admet-2861	117	10	been	be	AUX
admet-2861	117	11	previously	previously	ADV
admet-2861	117	12	measured	measure	VERB
admet-2861	117	13	or	or	CCONJ
admet-2861	117	14	is	be	AUX
admet-2861	117	15	being	be	AUX
admet-2861	117	16	measured	measure	VERB
admet-2861	117	17	by	by	ADP
admet-2861	117	18	the	the	DET
admet-2861	117	19	inhalation	inhalation	NOUN
admet-2861	117	20	device	device	NOUN
admet-2861	117	21	.	.	PUNCT
admet-2861	118	1	during	during	ADP
admet-2861	118	2	activation	activation	NOUN
admet-2861	118	3	,	,	PUNCT
admet-2861	118	4	the	the	DET
admet-2861	118	5	entire	entire	ADJ
admet-2861	118	6	dose	dose	NOUN
admet-2861	118	7	does	do	AUX
admet-2861	118	8	not	not	PART
admet-2861	118	9	leave	leave	VERB
admet-2861	118	10	the	the	DET
admet-2861	118	11	device	device	NOUN
admet-2861	118	12	;	;	PUNCT
admet-2861	118	13	the	the	DET
admet-2861	118	14	portion	portion	NOUN
admet-2861	118	15	that	that	PRON
admet-2861	118	16	leaves	leave	VERB
admet-2861	118	17	the	the	DET
admet-2861	118	18	device	device	NOUN
admet-2861	118	19	and	and	CCONJ
admet-2861	118	20	becomes	become	VERB
admet-2861	118	21	available	available	ADJ
admet-2861	118	22	for	for	ADP
admet-2861	118	23	inhalation	inhalation	NOUN
admet-2861	118	24	is	be	AUX
admet-2861	118	25	designated	designate	VERB
admet-2861	118	26	as	as	ADP
admet-2861	118	27	the	the	DET
admet-2861	118	28	delivered	deliver	VERB
admet-2861	118	29	dose	dose	NOUN
admet-2861	118	30	.	.	PUNCT
admet-2861	119	1	additionally	additionally	ADV
admet-2861	119	2	,	,	PUNCT
admet-2861	119	3	the	the	DET
admet-2861	119	4	entire	entire	ADJ
admet-2861	119	5	delivered	deliver	VERB
admet-2861	119	6	dose	dose	NOUN
admet-2861	119	7	does	do	AUX
admet-2861	119	8	not	not	PART
admet-2861	119	9	reach	reach	VERB
admet-2861	119	10	the	the	DET
admet-2861	119	11	site	site	NOUN
admet-2861	119	12	of	of	ADP
admet-2861	119	13	absorption	absorption	NOUN
admet-2861	119	14	.	.	PUNCT
admet-2861	120	1	it	it	PRON
admet-2861	120	2	is	be	AUX
admet-2861	120	3	a	a	DET
admet-2861	120	4	common	common	ADJ
admet-2861	120	5	opinion	opinion	NOUN
admet-2861	120	6	that	that	SCONJ
admet-2861	120	7	particles	particle	NOUN
admet-2861	120	8	with	with	ADP
admet-2861	120	9	an	an	DET
admet-2861	120	10	aerodynamic	aerodynamic	ADJ
admet-2861	120	11	diameter	diameter	NOUN
admet-2861	120	12	of	of	ADP
admet-2861	120	13	less	less	ADJ
admet-2861	120	14	than	than	ADP
admet-2861	120	15	5	5	NUM
admet-2861	120	16	µm	µm	ADP
admet-2861	120	17	reach	reach	VERB
admet-2861	120	18	and	and	CCONJ
admet-2861	120	19	are	be	AUX
admet-2861	120	20	deposited	deposit	VERB
admet-2861	120	21	in	in	ADP
admet-2861	120	22	the	the	DET
admet-2861	120	23	distal	distal	ADJ
admet-2861	120	24	parts	part	NOUN
admet-2861	120	25	of	of	ADP
admet-2861	120	26	the	the	DET
admet-2861	120	27	respiratory	respiratory	ADJ
admet-2861	120	28	tract	tract	NOUN
admet-2861	120	29	,	,	PUNCT
admet-2861	120	30	where	where	SCONJ
admet-2861	120	31	they	they	PRON
admet-2861	120	32	can	can	AUX
admet-2861	120	33	act	act	VERB
admet-2861	120	34	locally	locally	ADV
admet-2861	120	35	or	or	CCONJ
admet-2861	120	36	be	be	AUX
admet-2861	120	37	admet	admet	PROPN
admet-2861	120	38	&	&	CCONJ
admet-2861	120	39	dmpk	dmpk	PROPN
admet-2861	120	40	13	13	NUM
admet-2861	120	41	(	(	PUNCT
admet-2861	120	42	)	)	PUNCT
admet-2861	120	43	(	(	PUNCT
admet-2861	120	44	2025	2025	NUM
admet-2861	120	45	)	)	PUNCT
admet-2861	120	46	2861	2861	NUM
admet-2861	120	47	development	development	NOUN
admet-2861	120	48	of	of	ADP
admet-2861	120	49	a	a	DET
admet-2861	120	50	biorelevant	biorelevant	ADJ
admet-2861	120	51	dissolution	dissolution	NOUN
admet-2861	120	52	method	method	NOUN
admet-2861	120	53	for	for	ADP
admet-2861	120	54	inhalation	inhalation	NOUN
admet-2861	120	55	products	product	NOUN
admet-2861	120	56	doi	doi	NOUN
admet-2861	120	57	:	:	PUNCT
admet-2861	120	58	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	120	59	7	7	NUM
admet-2861	120	60	absorbed	absorb	VERB
admet-2861	120	61	.	.	PUNCT
admet-2861	121	1	therefore	therefore	ADV
admet-2861	121	2	,	,	PUNCT
admet-2861	121	3	the	the	DET
admet-2861	121	4	fpf	fpf	NOUN
admet-2861	121	5	of	of	ADP
admet-2861	121	6	the	the	DET
admet-2861	121	7	inhalation	inhalation	NOUN
admet-2861	121	8	products	product	NOUN
admet-2861	121	9	was	be	AUX
admet-2861	121	10	selected	select	VERB
admet-2861	121	11	as	as	ADP
admet-2861	121	12	the	the	DET
admet-2861	121	13	target	target	NOUN
admet-2861	121	14	sample	sample	NOUN
admet-2861	121	15	for	for	ADP
admet-2861	121	16	the	the	DET
admet-2861	121	17	release	release	NOUN
admet-2861	121	18	rate	rate	NOUN
admet-2861	121	19	test	test	NOUN
admet-2861	121	20	.	.	PUNCT
admet-2861	122	1	abbreviated	abbreviate	VERB
admet-2861	122	2	aci	aci	PROPN
admet-2861	122	3	was	be	AUX
admet-2861	122	4	used	use	VERB
admet-2861	122	5	for	for	ADP
admet-2861	122	6	its	its	PRON
admet-2861	122	7	collection	collection	NOUN
admet-2861	122	8	,	,	PUNCT
admet-2861	122	9	and	and	CCONJ
admet-2861	122	10	the	the	DET
admet-2861	122	11	fraction	fraction	NOUN
admet-2861	122	12	between	between	ADP
admet-2861	122	13	stages	stage	NOUN
admet-2861	122	14	2	2	NUM
admet-2861	122	15	and	and	CCONJ
admet-2861	122	16	7	7	NUM
admet-2861	122	17	was	be	AUX
admet-2861	122	18	collected	collect	VERB
admet-2861	122	19	.	.	PUNCT
admet-2861	123	1	the	the	DET
admet-2861	123	2	obtained	obtain	VERB
admet-2861	123	3	results	result	NOUN
admet-2861	123	4	are	be	AUX
admet-2861	123	5	presented	present	VERB
admet-2861	123	6	in	in	ADP
admet-2861	123	7	table	table	NOUN
admet-2861	123	8	2	2	NUM
admet-2861	123	9	.	.	PUNCT
admet-2861	124	1	the	the	DET
admet-2861	124	2	obtained	obtain	VERB
admet-2861	124	3	values	value	NOUN
admet-2861	124	4	were	be	AUX
admet-2861	124	5	used	use	VERB
admet-2861	124	6	to	to	PART
admet-2861	124	7	calculate	calculate	VERB
admet-2861	124	8	the	the	DET
admet-2861	124	9	proportion	proportion	NOUN
admet-2861	124	10	(	(	PUNCT
admet-2861	124	11	%	%	NOUN
admet-2861	124	12	)	)	PUNCT
admet-2861	124	13	of	of	ADP
admet-2861	124	14	the	the	DET
admet-2861	124	15	dissolved	dissolve	VERB
admet-2861	124	16	drug	drug	NOUN
admet-2861	124	17	during	during	ADP
admet-2861	124	18	the	the	DET
admet-2861	124	19	dissolution	dissolution	NOUN
admet-2861	124	20	test	test	NOUN
admet-2861	124	21	.	.	PUNCT
admet-2861	125	1	table	table	NOUN
admet-2861	125	2	2	2	NUM
admet-2861	125	3	.	.	PUNCT
admet-2861	125	4	experimentally	experimentally	ADV
admet-2861	125	5	determined	determine	VERB
admet-2861	125	6	amounts	amount	NOUN
admet-2861	125	7	of	of	ADP
admet-2861	125	8	the	the	DET
admet-2861	125	9	model	model	NOUN
admet-2861	125	10	drugs	drug	NOUN
admet-2861	125	11	deposited	deposit	VERB
admet-2861	125	12	on	on	ADP
admet-2861	125	13	the	the	DET
admet-2861	125	14	agar	agar	NOUN
admet-2861	125	15	membrane	membrane	NOUN
admet-2861	125	16	in	in	ADP
admet-2861	125	17	aaci	aaci	NOUN
admet-2861	125	18	stages	stage	VERB
admet-2861	125	19	2	2	NUM
admet-2861	125	20	-	-	SYM
admet-2861	125	21	7	7	NUM
admet-2861	125	22	sample	sample	NOUN
admet-2861	125	23	amount	amount	NOUN
admet-2861	125	24	of	of	ADP
admet-2861	125	25	deposited	deposit	VERB
admet-2861	125	26	active	active	ADJ
admet-2861	125	27	substance	substance	NOUN
admet-2861	125	28	per	per	ADP
admet-2861	125	29	dose	dose	NOUN
admet-2861	125	30	,	,	PUNCT
admet-2861	125	31	µg	µg	ADV
admet-2861	125	32	b1	b1	VERB
admet-2861	125	33	27.126	27.126	NUM
admet-2861	125	34	b2	b2	NOUN
admet-2861	125	35	21.809	21.809	NUM
admet-2861	125	36	b3	b3	NOUN
admet-2861	125	37	32.785	32.785	NUM
admet-2861	125	38	s1	s1	NOUN
admet-2861	125	39	7.099	7.099	NUM
admet-2861	125	40	s2	s2	NOUN
admet-2861	125	41	9.131	9.131	NUM
admet-2861	125	42	s3	s3	PROPN
admet-2861	125	43	5.563	5.563	NUM
admet-2861	125	44	s4	s4	PROPN
admet-2861	125	45	9.593	9.593	NUM
admet-2861	125	46	the	the	DET
admet-2861	125	47	choice	choice	NOUN
admet-2861	125	48	of	of	ADP
admet-2861	125	49	a	a	DET
admet-2861	125	50	medium	medium	NOUN
admet-2861	125	51	is	be	AUX
admet-2861	125	52	a	a	DET
admet-2861	125	53	critical	critical	ADJ
admet-2861	125	54	parameter	parameter	NOUN
admet-2861	125	55	for	for	ADP
admet-2861	125	56	designing	design	VERB
admet-2861	125	57	a	a	DET
admet-2861	125	58	dissolution	dissolution	ADJ
admet-2861	125	59	test	test	NOUN
admet-2861	125	60	.	.	PUNCT
admet-2861	126	1	the	the	DET
admet-2861	126	2	selected	select	VERB
admet-2861	126	3	medium	medium	NOUN
admet-2861	126	4	should	should	AUX
admet-2861	126	5	simulate	simulate	VERB
admet-2861	126	6	the	the	DET
admet-2861	126	7	physiological	physiological	ADJ
admet-2861	126	8	conditions	condition	NOUN
admet-2861	126	9	and	and	CCONJ
admet-2861	126	10	composition	composition	NOUN
admet-2861	126	11	of	of	ADP
admet-2861	126	12	the	the	DET
admet-2861	126	13	human	human	ADJ
admet-2861	126	14	body	body	NOUN
admet-2861	126	15	fluids	fluid	NOUN
admet-2861	126	16	,	,	PUNCT
admet-2861	126	17	but	but	CCONJ
admet-2861	126	18	on	on	ADP
admet-2861	126	19	the	the	DET
admet-2861	126	20	other	other	ADJ
admet-2861	126	21	hand	hand	NOUN
admet-2861	126	22	,	,	PUNCT
admet-2861	126	23	it	it	PRON
admet-2861	126	24	should	should	AUX
admet-2861	126	25	be	be	AUX
admet-2861	126	26	simple	simple	ADJ
admet-2861	126	27	,	,	PUNCT
admet-2861	126	28	stable	stable	ADJ
admet-2861	126	29	and	and	CCONJ
admet-2861	126	30	easy	easy	ADJ
admet-2861	126	31	to	to	PART
admet-2861	126	32	use	use	VERB
admet-2861	126	33	.	.	PUNCT
admet-2861	127	1	after	after	ADP
admet-2861	127	2	being	be	AUX
admet-2861	127	3	deposited	deposit	VERB
admet-2861	127	4	in	in	ADP
admet-2861	127	5	the	the	DET
admet-2861	127	6	respiratory	respiratory	ADJ
admet-2861	127	7	system	system	NOUN
admet-2861	127	8	,	,	PUNCT
admet-2861	127	9	the	the	DET
admet-2861	127	10	active	active	ADJ
admet-2861	127	11	substance	substance	NOUN
admet-2861	127	12	first	first	ADV
admet-2861	127	13	comes	come	VERB
admet-2861	127	14	into	into	ADP
admet-2861	127	15	contact	contact	NOUN
admet-2861	127	16	with	with	ADP
admet-2861	127	17	the	the	DET
admet-2861	127	18	lung	lung	NOUN
admet-2861	127	19	fluid	fluid	NOUN
admet-2861	127	20	,	,	PUNCT
admet-2861	127	21	in	in	ADP
admet-2861	127	22	which	which	PRON
admet-2861	127	23	it	it	PRON
admet-2861	127	24	must	must	AUX
admet-2861	127	25	dissolve	dissolve	VERB
admet-2861	127	26	to	to	PART
admet-2861	127	27	be	be	AUX
admet-2861	127	28	available	available	ADJ
admet-2861	127	29	for	for	ADP
admet-2861	127	30	absorption	absorption	NOUN
admet-2861	127	31	and	and	CCONJ
admet-2861	127	32	systemic	systemic	ADJ
admet-2861	127	33	or	or	CCONJ
admet-2861	127	34	local	local	ADJ
admet-2861	127	35	action	action	NOUN
admet-2861	127	36	.	.	PUNCT
admet-2861	128	1	lung	lung	NOUN
admet-2861	128	2	fluid	fluid	NOUN
admet-2861	128	3	plays	play	VERB
admet-2861	128	4	a	a	DET
admet-2861	128	5	crucial	crucial	ADJ
admet-2861	128	6	role	role	NOUN
admet-2861	128	7	in	in	ADP
admet-2861	128	8	maintaining	maintain	VERB
admet-2861	128	9	the	the	DET
admet-2861	128	10	structure	structure	NOUN
admet-2861	128	11	and	and	CCONJ
admet-2861	128	12	function	function	NOUN
admet-2861	128	13	of	of	ADP
admet-2861	128	14	the	the	DET
admet-2861	128	15	respiratory	respiratory	ADJ
admet-2861	128	16	system	system	NOUN
admet-2861	128	17	.	.	PUNCT
admet-2861	129	1	with	with	ADP
admet-2861	129	2	its	its	PRON
admet-2861	129	3	composition	composition	NOUN
admet-2861	129	4	and	and	CCONJ
admet-2861	129	5	surface	surface	NOUN
admet-2861	129	6	tension	tension	NOUN
admet-2861	129	7	effects	effect	NOUN
admet-2861	129	8	,	,	PUNCT
admet-2861	129	9	it	it	PRON
admet-2861	129	10	directly	directly	ADV
admet-2861	129	11	stabilizes	stabilize	VERB
admet-2861	129	12	the	the	DET
admet-2861	129	13	structure	structure	NOUN
admet-2861	129	14	and	and	CCONJ
admet-2861	129	15	prevents	prevent	VERB
admet-2861	129	16	the	the	DET
admet-2861	129	17	collapse	collapse	NOUN
admet-2861	129	18	of	of	ADP
admet-2861	129	19	the	the	DET
admet-2861	129	20	respiratory	respiratory	ADJ
admet-2861	129	21	system	system	NOUN
admet-2861	129	22	,	,	PUNCT
admet-2861	129	23	mediates	mediate	VERB
admet-2861	129	24	the	the	DET
admet-2861	129	25	transfer	transfer	NOUN
admet-2861	129	26	of	of	ADP
admet-2861	129	27	gases	gas	NOUN
admet-2861	129	28	between	between	ADP
admet-2861	129	29	inhaled	inhaled	ADJ
admet-2861	129	30	air	air	NOUN
admet-2861	129	31	and	and	CCONJ
admet-2861	129	32	blood	blood	NOUN
admet-2861	129	33	,	,	PUNCT
admet-2861	129	34	and	and	CCONJ
admet-2861	129	35	,	,	PUNCT
admet-2861	129	36	through	through	ADP
admet-2861	129	37	alveolar	alveolar	ADJ
admet-2861	129	38	macrophages	macrophage	NOUN
admet-2861	129	39	,	,	PUNCT
admet-2861	129	40	leukocytes	leukocyte	NOUN
admet-2861	129	41	,	,	PUNCT
admet-2861	129	42	and	and	CCONJ
admet-2861	129	43	secreted	secrete	VERB
admet-2861	129	44	antimicrobial	antimicrobial	ADJ
admet-2861	129	45	substances	substance	NOUN
admet-2861	129	46	,	,	PUNCT
admet-2861	129	47	forms	form	VERB
admet-2861	129	48	the	the	DET
admet-2861	129	49	basis	basis	NOUN
admet-2861	129	50	of	of	ADP
admet-2861	129	51	the	the	DET
admet-2861	129	52	body	body	NOUN
admet-2861	129	53	's	's	PART
admet-2861	129	54	defence	defence	NOUN
admet-2861	129	55	system	system	NOUN
admet-2861	129	56	in	in	ADP
admet-2861	129	57	the	the	DET
admet-2861	129	58	lungs	lung	NOUN
admet-2861	129	59	[	[	X
admet-2861	129	60	36	36	NUM
admet-2861	129	61	-	-	SYM
admet-2861	129	62	38	38	NUM
admet-2861	129	63	]	]	PUNCT
admet-2861	129	64	.	.	PUNCT
admet-2861	130	1	its	its	PRON
admet-2861	130	2	composition	composition	NOUN
admet-2861	130	3	varies	vary	VERB
admet-2861	130	4	depending	depend	VERB
admet-2861	130	5	on	on	ADP
admet-2861	130	6	the	the	DET
admet-2861	130	7	location	location	NOUN
admet-2861	130	8	in	in	ADP
admet-2861	130	9	the	the	DET
admet-2861	130	10	respiratory	respiratory	ADJ
admet-2861	130	11	system	system	NOUN
admet-2861	130	12	.	.	PUNCT
admet-2861	131	1	in	in	ADP
admet-2861	131	2	the	the	DET
admet-2861	131	3	upper	upper	ADJ
admet-2861	131	4	respiratory	respiratory	ADJ
admet-2861	131	5	tract	tract	NOUN
admet-2861	131	6	,	,	PUNCT
admet-2861	131	7	the	the	DET
admet-2861	131	8	lung	lung	NOUN
admet-2861	131	9	fluid	fluid	NOUN
admet-2861	131	10	layer	layer	NOUN
admet-2861	131	11	forms	form	VERB
admet-2861	131	12	a	a	DET
admet-2861	131	13	mucous	mucous	ADJ
admet-2861	131	14	gel	gel	NOUN
admet-2861	131	15	5	5	NUM
admet-2861	131	16	to	to	PART
admet-2861	131	17	100	100	NUM
admet-2861	131	18	µm	µm	ADP
admet-2861	131	19	thick	thick	ADJ
admet-2861	131	20	,	,	PUNCT
admet-2861	131	21	whereas	whereas	SCONJ
admet-2861	131	22	in	in	ADP
admet-2861	131	23	the	the	DET
admet-2861	131	24	lower	low	ADJ
admet-2861	131	25	respiratory	respiratory	ADJ
admet-2861	131	26	tract	tract	NOUN
admet-2861	131	27	,	,	PUNCT
admet-2861	131	28	the	the	DET
admet-2861	131	29	layer	layer	NOUN
admet-2861	131	30	is	be	AUX
admet-2861	131	31	less	less	ADV
admet-2861	131	32	viscous	viscous	ADJ
admet-2861	131	33	,	,	PUNCT
admet-2861	131	34	thinner	thin	ADJ
admet-2861	131	35	(	(	PUNCT
admet-2861	131	36	0.1	0.1	NUM
admet-2861	131	37	-	-	SYM
admet-2861	131	38	0.2	0.2	NUM
admet-2861	131	39	µm	µm	NOUN
admet-2861	131	40	)	)	PUNCT
admet-2861	131	41	,	,	PUNCT
admet-2861	131	42	and	and	CCONJ
admet-2861	131	43	rich	rich	ADJ
admet-2861	131	44	in	in	ADP
admet-2861	131	45	surfactants	surfactant	NOUN
admet-2861	131	46	[	[	X
admet-2861	131	47	37	37	NUM
admet-2861	131	48	]	]	PUNCT
admet-2861	131	49	.	.	PUNCT
admet-2861	132	1	based	base	VERB
admet-2861	132	2	on	on	ADP
admet-2861	132	3	the	the	DET
admet-2861	132	4	previous	previous	ADJ
admet-2861	132	5	considerations	consideration	NOUN
admet-2861	132	6	,	,	PUNCT
admet-2861	132	7	it	it	PRON
admet-2861	132	8	can	can	AUX
admet-2861	132	9	be	be	AUX
admet-2861	132	10	concluded	conclude	VERB
admet-2861	132	11	that	that	SCONJ
admet-2861	132	12	the	the	DET
admet-2861	132	13	“	"	PUNCT
admet-2861	132	14	target	target	NOUN
admet-2861	132	15	”	"	PUNCT
admet-2861	132	16	fluid	fluid	NOUN
admet-2861	132	17	for	for	ADP
admet-2861	132	18	in	in	ADP
admet-2861	132	19	vitro	vitro	X
admet-2861	132	20	dissolution	dissolution	NOUN
admet-2861	132	21	testing	testing	NOUN
admet-2861	132	22	of	of	ADP
admet-2861	132	23	an	an	DET
admet-2861	132	24	inhaled	inhaled	ADJ
admet-2861	132	25	drug	drug	NOUN
admet-2861	132	26	is	be	AUX
admet-2861	132	27	not	not	PART
admet-2861	132	28	simulated	simulate	VERB
admet-2861	132	29	lung	lung	NOUN
admet-2861	132	30	fluid	fluid	NOUN
admet-2861	132	31	[	[	X
admet-2861	132	32	39	39	NUM
admet-2861	132	33	]	]	PUNCT
admet-2861	132	34	,	,	PUNCT
admet-2861	132	35	but	but	CCONJ
admet-2861	132	36	rather	rather	ADV
admet-2861	132	37	a	a	DET
admet-2861	132	38	fluid	fluid	NOUN
admet-2861	132	39	whose	whose	DET
admet-2861	132	40	properties	property	NOUN
admet-2861	132	41	resemble	resemble	VERB
admet-2861	132	42	those	those	PRON
admet-2861	132	43	of	of	ADP
admet-2861	132	44	the	the	DET
admet-2861	132	45	interstitial	interstitial	ADJ
admet-2861	132	46	fluid	fluid	NOUN
admet-2861	132	47	and	and	CCONJ
admet-2861	132	48	is	be	AUX
admet-2861	132	49	easily	easily	ADV
admet-2861	132	50	prepared	prepared	ADJ
admet-2861	132	51	using	use	VERB
admet-2861	132	52	standard	standard	ADJ
admet-2861	132	53	,	,	PUNCT
admet-2861	132	54	readily	readily	ADV
admet-2861	132	55	accessible	accessible	ADJ
admet-2861	132	56	chemicals	chemical	NOUN
admet-2861	132	57	.	.	PUNCT
admet-2861	133	1	isotonic	isotonic	ADJ
admet-2861	133	2	phosphate	phosphate	NOUN
admet-2861	133	3	buffer	buffer	NOUN
admet-2861	133	4	(	(	PUNCT
admet-2861	133	5	phosphate	phosphate	ADJ
admet-2861	133	6	buffer	buffer	NOUN
admet-2861	133	7	saline	saline	NOUN
admet-2861	133	8	–	–	PUNCT
admet-2861	133	9	pbs	pbs	PROPN
admet-2861	133	10	)	)	PUNCT
admet-2861	133	11	,	,	PUNCT
admet-2861	133	12	often	often	ADV
admet-2861	133	13	used	use	VERB
admet-2861	133	14	in	in	ADP
admet-2861	133	15	biochemical	biochemical	ADJ
admet-2861	133	16	analyses	analysis	NOUN
admet-2861	133	17	and	and	CCONJ
admet-2861	133	18	research	research	NOUN
admet-2861	133	19	,	,	PUNCT
admet-2861	133	20	was	be	AUX
admet-2861	133	21	chosen	choose	VERB
admet-2861	133	22	because	because	SCONJ
admet-2861	133	23	it	it	PRON
admet-2861	133	24	is	be	AUX
admet-2861	133	25	isotonic	isotonic	ADJ
admet-2861	133	26	,	,	PUNCT
admet-2861	133	27	has	have	VERB
admet-2861	133	28	a	a	DET
admet-2861	133	29	physiological	physiological	ADJ
admet-2861	133	30	ph	ph	NOUN
admet-2861	133	31	(	(	PUNCT
admet-2861	133	32	7.4	7.4	NUM
admet-2861	133	33	)	)	PUNCT
admet-2861	133	34	,	,	PUNCT
admet-2861	133	35	and	and	CCONJ
admet-2861	133	36	osmolality	osmolality	NOUN
admet-2861	133	37	and	and	CCONJ
admet-2861	133	38	ion	ion	NOUN
admet-2861	133	39	concentrations	concentration	NOUN
admet-2861	133	40	similar	similar	ADJ
admet-2861	133	41	to	to	ADP
admet-2861	133	42	those	those	PRON
admet-2861	133	43	of	of	ADP
admet-2861	133	44	human	human	ADJ
admet-2861	133	45	physiological	physiological	ADJ
admet-2861	133	46	values	value	NOUN
admet-2861	133	47	.	.	PUNCT
admet-2861	134	1	pbs	pbs	PROPN
admet-2861	134	2	is	be	AUX
admet-2861	134	3	stable	stable	ADJ
admet-2861	134	4	,	,	PUNCT
admet-2861	134	5	has	have	AUX
admet-2861	134	6	a	a	DET
admet-2861	134	7	good	good	ADJ
admet-2861	134	8	buffer	buffer	NOUN
admet-2861	134	9	capacity	capacity	NOUN
admet-2861	134	10	,	,	PUNCT
admet-2861	134	11	and	and	CCONJ
admet-2861	134	12	is	be	AUX
admet-2861	134	13	physiologically	physiologically	ADV
admet-2861	134	14	compatible	compatible	ADJ
admet-2861	134	15	.	.	PUNCT
admet-2861	135	1	when	when	SCONJ
admet-2861	135	2	selecting	select	VERB
admet-2861	135	3	an	an	DET
admet-2861	135	4	appropriate	appropriate	ADJ
admet-2861	135	5	dissolution	dissolution	NOUN
admet-2861	135	6	medium	medium	NOUN
admet-2861	135	7	,	,	PUNCT
admet-2861	135	8	it	it	PRON
admet-2861	135	9	is	be	AUX
admet-2861	135	10	often	often	ADV
admet-2861	135	11	recommended	recommend	VERB
admet-2861	135	12	to	to	PART
admet-2861	135	13	ensure	ensure	VERB
admet-2861	135	14	that	that	SCONJ
admet-2861	135	15	sink	sink	NOUN
admet-2861	135	16	conditions	condition	NOUN
admet-2861	135	17	are	be	AUX
admet-2861	135	18	met	meet	VERB
admet-2861	135	19	.	.	PUNCT
admet-2861	136	1	sink	sink	NOUN
admet-2861	136	2	conditions	condition	NOUN
admet-2861	136	3	are	be	AUX
admet-2861	136	4	met	meet	VERB
admet-2861	136	5	when	when	SCONJ
admet-2861	136	6	the	the	DET
admet-2861	136	7	medium	medium	ADJ
admet-2861	136	8	volume	volume	NOUN
admet-2861	136	9	can	can	AUX
admet-2861	136	10	dissolve	dissolve	VERB
admet-2861	136	11	at	at	ADP
admet-2861	136	12	least	least	ADV
admet-2861	136	13	three	three	NUM
admet-2861	136	14	times	time	NOUN
admet-2861	136	15	the	the	DET
admet-2861	136	16	drug	drug	NOUN
admet-2861	136	17	dose	dose	NOUN
admet-2861	136	18	used	use	VERB
admet-2861	136	19	in	in	ADP
admet-2861	136	20	the	the	DET
admet-2861	136	21	test	test	NOUN
admet-2861	136	22	[	[	X
admet-2861	136	23	40	40	NUM
admet-2861	136	24	]	]	PUNCT
admet-2861	136	25	.	.	PUNCT
admet-2861	137	1	the	the	DET
admet-2861	137	2	use	use	NOUN
admet-2861	137	3	of	of	ADP
admet-2861	137	4	physiological	physiological	ADJ
admet-2861	137	5	surfactants	surfactant	NOUN
admet-2861	137	6	present	present	ADJ
admet-2861	137	7	in	in	ADP
admet-2861	137	8	the	the	DET
admet-2861	137	9	lung	lung	NOUN
admet-2861	137	10	is	be	AUX
admet-2861	137	11	not	not	PART
admet-2861	137	12	practical	practical	ADJ
admet-2861	137	13	due	due	ADP
admet-2861	137	14	to	to	ADP
admet-2861	137	15	the	the	DET
admet-2861	137	16	complex	complex	ADJ
admet-2861	137	17	procedure	procedure	NOUN
admet-2861	137	18	required	require	VERB
admet-2861	137	19	for	for	ADP
admet-2861	137	20	medium	medium	ADJ
admet-2861	137	21	preparation	preparation	NOUN
admet-2861	137	22	and	and	CCONJ
admet-2861	137	23	their	their	PRON
admet-2861	137	24	limited	limited	ADJ
admet-2861	137	25	availability	availability	NOUN
admet-2861	137	26	.	.	PUNCT
admet-2861	138	1	therefore	therefore	ADV
admet-2861	138	2	,	,	PUNCT
admet-2861	138	3	surfactants	surfactant	NOUN
admet-2861	138	4	commonly	commonly	ADV
admet-2861	138	5	used	use	VERB
admet-2861	138	6	for	for	ADP
admet-2861	138	7	dissolution	dissolution	ADJ
admet-2861	138	8	testing	testing	NOUN
admet-2861	138	9	of	of	ADP
admet-2861	138	10	oral	oral	ADJ
admet-2861	138	11	solid	solid	ADJ
admet-2861	138	12	dosage	dosage	NOUN
admet-2861	138	13	forms	form	NOUN
admet-2861	138	14	were	be	AUX
admet-2861	138	15	selected	select	VERB
admet-2861	138	16	:	:	PUNCT
admet-2861	138	17	sds	sds	NOUN
admet-2861	138	18	and	and	CCONJ
admet-2861	138	19	polysorbate	polysorbate	NOUN
admet-2861	138	20	80	80	NUM
admet-2861	138	21	.	.	PUNCT
admet-2861	139	1	the	the	DET
admet-2861	139	2	experimentally	experimentally	ADV
admet-2861	139	3	obtained	obtain	VERB
admet-2861	139	4	solubility	solubility	NOUN
admet-2861	139	5	of	of	ADP
admet-2861	139	6	sx	sx	PROPN
admet-2861	139	7	in	in	ADP
admet-2861	139	8	pbs	pbs	PROPN
admet-2861	139	9	was	be	AUX
admet-2861	139	10	0.155	0.155	NUM
admet-2861	139	11	mg	mg	NUM
admet-2861	139	12	ml-1	ml-1	PROPN
admet-2861	139	13	.	.	PUNCT
admet-2861	140	1	this	this	DET
admet-2861	140	2	solubility	solubility	NOUN
admet-2861	140	3	allowed	allow	VERB
admet-2861	140	4	sink	sink	NOUN
admet-2861	140	5	conditions	condition	NOUN
admet-2861	140	6	to	to	PART
admet-2861	140	7	be	be	AUX
admet-2861	140	8	achieved	achieve	VERB
admet-2861	140	9	without	without	ADP
admet-2861	140	10	the	the	DET
admet-2861	140	11	addition	addition	NOUN
admet-2861	140	12	of	of	ADP
admet-2861	140	13	surfactants	surfactant	NOUN
admet-2861	140	14	to	to	ADP
admet-2861	140	15	the	the	DET
admet-2861	140	16	medium	medium	NOUN
admet-2861	140	17	;	;	PUNCT
admet-2861	140	18	therefore	therefore	ADV
admet-2861	140	19	,	,	PUNCT
admet-2861	140	20	pbs	pbs	PROPN
admet-2861	140	21	was	be	AUX
admet-2861	140	22	used	use	VERB
admet-2861	140	23	as	as	ADP
admet-2861	140	24	the	the	DET
admet-2861	140	25	test	test	NOUN
admet-2861	140	26	medium	medium	NOUN
admet-2861	140	27	for	for	ADP
admet-2861	140	28	sx	sx	PROPN
admet-2861	140	29	.	.	PROPN
admet-2861	140	30	bdp	bdp	PROPN
admet-2861	140	31	is	be	AUX
admet-2861	140	32	poorly	poorly	ADV
admet-2861	140	33	soluble	soluble	ADJ
admet-2861	140	34	in	in	ADP
admet-2861	140	35	pbs	pbs	PROPN
admet-2861	140	36	(	(	PUNCT
admet-2861	140	37	solubility	solubility	NOUN
admet-2861	140	38	in	in	ADP
admet-2861	140	39	water	water	NOUN
admet-2861	140	40	is	be	AUX
admet-2861	140	41	2.1	2.1	NUM
admet-2861	140	42	µg	µg	ADV
admet-2861	140	43	ml-1	ml-1	PART
admet-2861	141	1	[	[	X
admet-2861	141	2	41	41	NUM
admet-2861	141	3	]	]	PUNCT
admet-2861	141	4	)	)	PUNCT
admet-2861	142	1	and	and	CCONJ
admet-2861	142	2	requires	require	VERB
admet-2861	142	3	the	the	DET
admet-2861	142	4	addition	addition	NOUN
admet-2861	142	5	of	of	ADP
admet-2861	142	6	surfactants	surfactant	NOUN
admet-2861	142	7	to	to	PART
admet-2861	142	8	achieve	achieve	VERB
admet-2861	142	9	sink	sink	NOUN
admet-2861	142	10	conditions	condition	NOUN
admet-2861	142	11	.	.	PUNCT
admet-2861	143	1	the	the	DET
admet-2861	143	2	solubility	solubility	NOUN
admet-2861	143	3	of	of	ADP
admet-2861	143	4	bdp	bdp	PROPN
admet-2861	143	5	in	in	ADP
admet-2861	143	6	solutions	solution	NOUN
admet-2861	143	7	of	of	ADP
admet-2861	143	8	sds	sds	NOUN
admet-2861	143	9	and	and	CCONJ
admet-2861	143	10	polysorbate	polysorbate	NOUN
admet-2861	143	11	80	80	NUM
admet-2861	143	12	in	in	ADP
admet-2861	143	13	pbs	pbs	PROPN
admet-2861	143	14	was	be	AUX
admet-2861	143	15	tested	test	VERB
admet-2861	143	16	.	.	PUNCT
admet-2861	144	1	the	the	DET
admet-2861	144	2	obtained	obtain	VERB
admet-2861	144	3	results	result	NOUN
admet-2861	144	4	are	be	AUX
admet-2861	144	5	presented	present	VERB
admet-2861	144	6	in	in	ADP
admet-2861	144	7	table	table	NOUN
admet-2861	144	8	3	3	NUM
admet-2861	144	9	.	.	PUNCT
admet-2861	145	1	the	the	DET
admet-2861	145	2	obtained	obtain	VERB
admet-2861	145	3	results	result	NOUN
admet-2861	145	4	indicate	indicate	VERB
admet-2861	145	5	that	that	SCONJ
admet-2861	145	6	bdp	bdp	PROPN
admet-2861	145	7	exhibits	exhibit	VERB
admet-2861	145	8	sink	sink	NOUN
admet-2861	145	9	conditions	condition	NOUN
admet-2861	145	10	in	in	ADP
admet-2861	145	11	0.5	0.5	NUM
admet-2861	145	12	and	and	CCONJ
admet-2861	145	13	1	1	NUM
admet-2861	145	14	%	%	NOUN
admet-2861	145	15	sds	sds	PROPN
admet-2861	145	16	solutions	solution	NOUN
admet-2861	145	17	,	,	PUNCT
admet-2861	145	18	as	as	SCONJ
admet-2861	145	19	solubility	solubility	NOUN
admet-2861	145	20	exceeds	exceed	VERB
admet-2861	145	21	three	three	NUM
admet-2861	145	22	times	time	NOUN
admet-2861	145	23	the	the	DET
admet-2861	145	24	maximum	maximum	ADJ
admet-2861	145	25	theoretical	theoretical	ADJ
admet-2861	145	26	concentration	concentration	NOUN
admet-2861	145	27	of	of	ADP
admet-2861	145	28	bdp	bdp	PROPN
admet-2861	145	29	in	in	ADP
admet-2861	145	30	the	the	DET
admet-2861	145	31	medium	medium	NOUN
admet-2861	145	32	during	during	ADP
admet-2861	145	33	the	the	DET
admet-2861	145	34	dissolution	dissolution	NOUN
admet-2861	145	35	test	test	NOUN
admet-2861	145	36	(	(	PUNCT
admet-2861	145	37	10	10	NUM
admet-2861	145	38	µg	µg	ADV
admet-2861	145	39	ml-1	ml-1	NUM
admet-2861	145	40	)	)	PUNCT
admet-2861	145	41	.	.	PUNCT
admet-2861	146	1	1	1	NUM
admet-2861	146	2	%	%	NOUN
admet-2861	146	3	sds	sds	NOUN
admet-2861	146	4	solution	solution	NOUN
admet-2861	146	5	was	be	AUX
admet-2861	146	6	chosen	choose	VERB
admet-2861	146	7	as	as	ADP
admet-2861	146	8	the	the	DET
admet-2861	146	9	medium	medium	NOUN
admet-2861	146	10	,	,	PUNCT
admet-2861	146	11	providing	provide	VERB
admet-2861	146	12	the	the	DET
admet-2861	146	13	robustness	robustness	NOUN
admet-2861	146	14	for	for	ADP
admet-2861	146	15	testing	test	VERB
admet-2861	146	16	the	the	DET
admet-2861	146	17	release	release	NOUN
admet-2861	146	18	rate	rate	NOUN
admet-2861	146	19	of	of	ADP
admet-2861	146	20	inhalation	inhalation	NOUN
admet-2861	146	21	products	product	NOUN
admet-2861	146	22	with	with	ADP
admet-2861	146	23	bdp	bdp	PROPN
admet-2861	146	24	.	.	PROPN
admet-2861	147	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	147	2	a.	a.	PROPN
admet-2861	147	3	elezović	elezović	PROPN
admet-2861	147	4	et	et	PROPN
admet-2861	147	5	al	al	PROPN
admet-2861	147	6	.	.	PROPN
admet-2861	147	7	admet	admet	PROPN
admet-2861	147	8	&	&	CCONJ
admet-2861	147	9	dmpk	dmpk	PROPN
admet-2861	147	10	13(5	13(5	NUM
admet-2861	147	11	)	)	PUNCT
admet-2861	147	12	(	(	PUNCT
admet-2861	147	13	2025	2025	NUM
admet-2861	147	14	)	)	PUNCT
admet-2861	147	15	2861	2861	NUM
admet-2861	147	16	8	8	NUM
admet-2861	147	17	table	table	NOUN
admet-2861	147	18	3	3	NUM
admet-2861	147	19	.	.	PUNCT
admet-2861	147	20	experimentally	experimentally	ADV
admet-2861	147	21	determined	determine	VERB
admet-2861	147	22	solubility	solubility	NOUN
admet-2861	147	23	of	of	ADP
admet-2861	147	24	bdp	bdp	PROPN
admet-2861	147	25	in	in	ADP
admet-2861	147	26	different	different	ADJ
admet-2861	147	27	solvents	solvent	NOUN
admet-2861	147	28	solvent	solvent	NOUN
admet-2861	147	29	solubility	solubility	NOUN
admet-2861	147	30	,	,	PUNCT
admet-2861	147	31	µg	µg	ADP
admet-2861	147	32	ml-1	ml-1	PRON
admet-2861	147	33	pbs	pbs	PROPN
admet-2861	147	34	2.96	2.96	NUM
admet-2861	147	35	1	1	NUM
admet-2861	147	36	%	%	NOUN
admet-2861	147	37	polysorbate	polysorbate	NOUN
admet-2861	147	38	80	80	NUM
admet-2861	147	39	in	in	ADP
admet-2861	147	40	pbs	pbs	PROPN
admet-2861	147	41	9.64	9.64	NUM
admet-2861	147	42	0.5	0.5	NUM
admet-2861	147	43	%	%	NOUN
admet-2861	147	44	sds	sds	PROPN
admet-2861	147	45	in	in	ADP
admet-2861	147	46	pbs	pbs	PROPN
admet-2861	147	47	48.96	48.96	NUM
admet-2861	147	48	1	1	NUM
admet-2861	147	49	%	%	NOUN
admet-2861	147	50	sds	sds	PROPN
admet-2861	147	51	in	in	ADP
admet-2861	147	52	pbs	pbs	PROPN
admet-2861	147	53	93.16	93.16	NUM
admet-2861	147	54	membranes	membrane	NOUN
admet-2861	147	55	are	be	AUX
admet-2861	147	56	an	an	DET
admet-2861	147	57	integral	integral	ADJ
admet-2861	147	58	part	part	NOUN
admet-2861	147	59	of	of	ADP
admet-2861	147	60	all	all	DET
admet-2861	147	61	systems	system	NOUN
admet-2861	147	62	described	describe	VERB
admet-2861	147	63	so	so	ADV
admet-2861	147	64	far	far	ADV
admet-2861	147	65	for	for	ADP
admet-2861	147	66	testing	test	VERB
admet-2861	147	67	the	the	DET
admet-2861	147	68	release	release	NOUN
admet-2861	147	69	rate	rate	NOUN
admet-2861	147	70	of	of	ADP
admet-2861	147	71	inhalation	inhalation	NOUN
admet-2861	147	72	products	product	NOUN
admet-2861	148	1	[	[	X
admet-2861	148	2	9,14	9,14	NUM
admet-2861	148	3	-	-	SYM
admet-2861	148	4	21,24,42,43	21,24,42,43	NUM
admet-2861	148	5	]	]	PUNCT
admet-2861	148	6	.	.	PUNCT
admet-2861	149	1	membranes	membrane	NOUN
admet-2861	149	2	made	make	VERB
admet-2861	149	3	of	of	ADP
admet-2861	149	4	polycarbonate	polycarbonate	NOUN
admet-2861	149	5	,	,	PUNCT
admet-2861	149	6	teflon	teflon	NOUN
admet-2861	149	7	®	®	NOUN
admet-2861	149	8	,	,	PUNCT
admet-2861	149	9	various	various	ADJ
admet-2861	149	10	cellulose	cellulose	NOUN
admet-2861	149	11	derivatives	derivative	NOUN
admet-2861	149	12	or	or	CCONJ
admet-2861	149	13	nylon	nylon	NOUN
admet-2861	149	14	have	have	AUX
admet-2861	149	15	been	be	AUX
admet-2861	149	16	used	use	VERB
admet-2861	149	17	.	.	PUNCT
admet-2861	150	1	the	the	DET
admet-2861	150	2	primary	primary	ADJ
admet-2861	150	3	role	role	NOUN
admet-2861	150	4	of	of	ADP
admet-2861	150	5	the	the	DET
admet-2861	150	6	membrane	membrane	NOUN
admet-2861	150	7	in	in	ADP
admet-2861	150	8	these	these	DET
admet-2861	150	9	experiments	experiment	NOUN
admet-2861	150	10	is	be	AUX
admet-2861	150	11	physical	physical	ADJ
admet-2861	150	12	retention	retention	NOUN
admet-2861	150	13	of	of	ADP
admet-2861	150	14	particles	particle	NOUN
admet-2861	150	15	and	and	CCONJ
admet-2861	150	16	testing	test	VERB
admet-2861	150	17	the	the	DET
admet-2861	150	18	influence	influence	NOUN
admet-2861	150	19	of	of	ADP
admet-2861	150	20	the	the	DET
admet-2861	150	21	membrane	membrane	NOUN
admet-2861	150	22	on	on	ADP
admet-2861	150	23	the	the	DET
admet-2861	150	24	dissolution	dissolution	NOUN
admet-2861	150	25	process	process	NOUN
admet-2861	150	26	itself	itself	PRON
admet-2861	150	27	was	be	AUX
admet-2861	150	28	not	not	PART
admet-2861	150	29	the	the	DET
admet-2861	150	30	focus	focus	NOUN
admet-2861	150	31	of	of	ADP
admet-2861	150	32	these	these	DET
admet-2861	150	33	studies	study	NOUN
admet-2861	150	34	.	.	PUNCT
admet-2861	151	1	considering	consider	VERB
admet-2861	151	2	the	the	DET
admet-2861	151	3	choice	choice	NOUN
admet-2861	151	4	of	of	ADP
admet-2861	151	5	dissolution	dissolution	ADJ
admet-2861	151	6	medium	medium	NOUN
admet-2861	151	7	,	,	PUNCT
admet-2861	151	8	which	which	PRON
admet-2861	151	9	should	should	AUX
admet-2861	151	10	simulate	simulate	VERB
admet-2861	151	11	extracellular	extracellular	ADJ
admet-2861	151	12	fluid	fluid	NOUN
admet-2861	151	13	and	and	CCONJ
admet-2861	151	14	plasma	plasma	NOUN
admet-2861	151	15	,	,	PUNCT
admet-2861	151	16	the	the	DET
admet-2861	151	17	largest	large	ADJ
admet-2861	151	18	and	and	CCONJ
admet-2861	151	19	thickest	thick	ADJ
admet-2861	151	20	membrane	membrane	NOUN
admet-2861	151	21	between	between	ADP
admet-2861	151	22	the	the	DET
admet-2861	151	23	space	space	NOUN
admet-2861	151	24	filled	fill	VERB
admet-2861	151	25	by	by	ADP
admet-2861	151	26	this	this	DET
admet-2861	151	27	fluid	fluid	NOUN
admet-2861	151	28	and	and	CCONJ
admet-2861	151	29	the	the	DET
admet-2861	151	30	site	site	NOUN
admet-2861	151	31	of	of	ADP
admet-2861	151	32	deposition	deposition	NOUN
admet-2861	151	33	of	of	ADP
admet-2861	151	34	active	active	ADJ
admet-2861	151	35	substance	substance	NOUN
admet-2861	151	36	particles	particle	NOUN
admet-2861	151	37	is	be	AUX
admet-2861	151	38	the	the	DET
admet-2861	151	39	mucous	mucous	ADJ
admet-2861	151	40	membrane	membrane	NOUN
admet-2861	151	41	.	.	PUNCT
admet-2861	152	1	that	that	DET
admet-2861	152	2	membrane	membrane	NOUN
admet-2861	152	3	comprises	comprise	VERB
admet-2861	152	4	97	97	NUM
admet-2861	152	5	%	%	NOUN
admet-2861	152	6	water	water	NOUN
admet-2861	152	7	and	and	CCONJ
admet-2861	152	8	3	3	NUM
admet-2861	152	9	%	%	NOUN
admet-2861	152	10	dry	dry	ADJ
admet-2861	152	11	matter	matter	NOUN
admet-2861	152	12	(	(	PUNCT
admet-2861	152	13	mucins	mucin	NOUN
admet-2861	152	14	,	,	PUNCT
admet-2861	152	15	nonmucin	nonmucin	NOUN
admet-2861	152	16	proteins	protein	NOUN
admet-2861	152	17	,	,	PUNCT
admet-2861	152	18	salts	salt	NOUN
admet-2861	152	19	,	,	PUNCT
admet-2861	152	20	lipids	lipid	NOUN
admet-2861	152	21	,	,	PUNCT
admet-2861	152	22	and	and	CCONJ
admet-2861	152	23	cellular	cellular	ADJ
admet-2861	152	24	debris	debris	NOUN
admet-2861	152	25	)	)	PUNCT
admet-2861	153	1	[	[	X
admet-2861	153	2	44	44	NUM
admet-2861	153	3	]	]	PUNCT
admet-2861	153	4	.	.	PUNCT
admet-2861	154	1	the	the	DET
admet-2861	154	2	membrane	membrane	NOUN
admet-2861	154	3	for	for	ADP
admet-2861	154	4	the	the	DET
admet-2861	154	5	dissolution	dissolution	NOUN
admet-2861	154	6	test	test	NOUN
admet-2861	154	7	,	,	PUNCT
admet-2861	154	8	in	in	ADP
admet-2861	154	9	addition	addition	NOUN
admet-2861	154	10	to	to	ADP
admet-2861	154	11	being	be	AUX
admet-2861	154	12	readily	readily	ADV
admet-2861	154	13	available	available	ADJ
admet-2861	154	14	and	and	CCONJ
admet-2861	154	15	easy	easy	ADJ
admet-2861	154	16	to	to	PART
admet-2861	154	17	prepare	prepare	VERB
admet-2861	154	18	,	,	PUNCT
admet-2861	154	19	should	should	AUX
admet-2861	154	20	be	be	AUX
admet-2861	154	21	mechanically	mechanically	ADV
admet-2861	154	22	stable	stable	ADJ
admet-2861	154	23	and	and	CCONJ
admet-2861	154	24	have	have	VERB
admet-2861	154	25	a	a	DET
admet-2861	154	26	composition	composition	NOUN
admet-2861	154	27	and	and	CCONJ
admet-2861	154	28	porosity	porosity	NOUN
admet-2861	154	29	similar	similar	ADJ
admet-2861	154	30	to	to	ADP
admet-2861	154	31	those	those	PRON
admet-2861	154	32	of	of	ADP
admet-2861	154	33	the	the	DET
admet-2861	154	34	mucous	mucous	ADJ
admet-2861	154	35	membrane	membrane	NOUN
admet-2861	154	36	of	of	ADP
admet-2861	154	37	the	the	DET
admet-2861	154	38	respiratory	respiratory	ADJ
admet-2861	154	39	tract	tract	NOUN
admet-2861	154	40	.	.	PUNCT
admet-2861	155	1	a	a	DET
admet-2861	155	2	membrane	membrane	NOUN
admet-2861	155	3	made	make	VERB
admet-2861	155	4	of	of	ADP
admet-2861	155	5	agar	agar	NOUN
admet-2861	155	6	,	,	PUNCT
admet-2861	155	7	although	although	SCONJ
admet-2861	155	8	not	not	PART
admet-2861	155	9	corresponding	correspond	VERB
admet-2861	155	10	in	in	ADP
admet-2861	155	11	composition	composition	NOUN
admet-2861	155	12	to	to	ADP
admet-2861	155	13	that	that	PRON
admet-2861	155	14	of	of	ADP
admet-2861	155	15	the	the	DET
admet-2861	155	16	mucous	mucous	ADJ
admet-2861	155	17	membrane	membrane	NOUN
admet-2861	155	18	in	in	ADP
admet-2861	155	19	the	the	DET
admet-2861	155	20	lungs	lung	NOUN
admet-2861	155	21	,	,	PUNCT
admet-2861	155	22	meets	meet	VERB
admet-2861	155	23	all	all	DET
admet-2861	155	24	other	other	ADJ
admet-2861	155	25	requirements	requirement	NOUN
admet-2861	155	26	.	.	PUNCT
admet-2861	156	1	mechanical	mechanical	ADJ
admet-2861	156	2	strength	strength	NOUN
admet-2861	156	3	can	can	AUX
admet-2861	156	4	be	be	AUX
admet-2861	156	5	achieved	achieve	VERB
admet-2861	156	6	by	by	ADP
admet-2861	156	7	incorporating	incorporate	VERB
admet-2861	156	8	glass	glass	NOUN
admet-2861	156	9	fiber	fiber	NOUN
admet-2861	156	10	filters	filter	NOUN
admet-2861	156	11	into	into	ADP
admet-2861	156	12	the	the	DET
admet-2861	156	13	membrane	membrane	NOUN
admet-2861	156	14	structure	structure	NOUN
admet-2861	156	15	.	.	PUNCT
admet-2861	157	1	in	in	ADP
admet-2861	157	2	this	this	DET
admet-2861	157	3	way	way	NOUN
admet-2861	157	4	,	,	PUNCT
admet-2861	157	5	a	a	DET
admet-2861	157	6	polysaccharide	polysaccharide	NOUN
admet-2861	157	7	membrane	membrane	NOUN
admet-2861	157	8	with	with	ADP
admet-2861	157	9	a	a	DET
admet-2861	157	10	standardized	standardized	ADJ
admet-2861	157	11	composition	composition	NOUN
admet-2861	157	12	and	and	CCONJ
admet-2861	157	13	structure	structure	NOUN
admet-2861	157	14	was	be	AUX
admet-2861	157	15	obtained	obtain	VERB
admet-2861	157	16	,	,	PUNCT
admet-2861	157	17	exhibiting	exhibit	VERB
admet-2861	157	18	satisfactory	satisfactory	ADJ
admet-2861	157	19	mechanical	mechanical	ADJ
admet-2861	157	20	properties	property	NOUN
admet-2861	157	21	that	that	PRON
admet-2861	157	22	enable	enable	VERB
admet-2861	157	23	necessary	necessary	ADJ
admet-2861	157	24	manipulation	manipulation	NOUN
admet-2861	157	25	without	without	ADP
admet-2861	157	26	compromising	compromise	VERB
admet-2861	157	27	the	the	DET
admet-2861	157	28	physical	physical	ADJ
admet-2861	157	29	integrity	integrity	NOUN
admet-2861	157	30	of	of	ADP
admet-2861	157	31	the	the	DET
admet-2861	157	32	membrane	membrane	NOUN
admet-2861	157	33	.	.	PUNCT
admet-2861	158	1	this	this	DET
admet-2861	158	2	membrane	membrane	NOUN
admet-2861	158	3	was	be	AUX
admet-2861	158	4	stable	stable	ADJ
admet-2861	158	5	and	and	CCONJ
admet-2861	158	6	insoluble	insoluble	ADJ
admet-2861	158	7	in	in	ADP
admet-2861	158	8	the	the	DET
admet-2861	158	9	dissolution	dissolution	NOUN
admet-2861	158	10	medium	medium	NOUN
admet-2861	158	11	.	.	PUNCT
admet-2861	159	1	the	the	DET
admet-2861	159	2	principle	principle	NOUN
admet-2861	159	3	of	of	ADP
admet-2861	159	4	the	the	DET
admet-2861	159	5	paddle	paddle	NOUN
admet-2861	159	6	over	over	ADP
admet-2861	159	7	disc	disc	NOUN
admet-2861	159	8	apparatus	apparatus	NOUN
admet-2861	159	9	(	(	PUNCT
admet-2861	159	10	usp	usp	NOUN
admet-2861	159	11	app	app	PROPN
admet-2861	159	12	.	.	PROPN
admet-2861	159	13	5	5	NUM
admet-2861	159	14	)	)	PUNCT
admet-2861	159	15	was	be	AUX
admet-2861	159	16	chosen	choose	VERB
admet-2861	159	17	as	as	ADP
admet-2861	159	18	the	the	DET
admet-2861	159	19	basis	basis	NOUN
admet-2861	159	20	for	for	ADP
admet-2861	159	21	the	the	DET
admet-2861	159	22	development	development	NOUN
admet-2861	159	23	of	of	ADP
admet-2861	159	24	the	the	DET
admet-2861	159	25	method	method	NOUN
admet-2861	159	26	.	.	PUNCT
admet-2861	160	1	sample	sample	NOUN
admet-2861	160	2	processing	processing	NOUN
admet-2861	160	3	and	and	CCONJ
admet-2861	160	4	placement	placement	NOUN
admet-2861	160	5	in	in	ADP
admet-2861	160	6	other	other	ADJ
admet-2861	160	7	reported	report	VERB
admet-2861	160	8	dissolution	dissolution	NOUN
admet-2861	160	9	systems	system	NOUN
admet-2861	160	10	is	be	AUX
admet-2861	160	11	more	more	ADV
admet-2861	160	12	complicated	complicated	ADJ
admet-2861	160	13	and	and	CCONJ
admet-2861	160	14	subject	subject	ADJ
admet-2861	160	15	to	to	ADP
admet-2861	160	16	greater	great	ADJ
admet-2861	160	17	errors	error	NOUN
admet-2861	160	18	due	due	ADP
admet-2861	160	19	to	to	ADP
admet-2861	160	20	the	the	DET
admet-2861	160	21	larger	large	ADJ
admet-2861	160	22	number	number	NOUN
admet-2861	160	23	of	of	ADP
admet-2861	160	24	sample	sample	NOUN
admet-2861	160	25	preparation	preparation	NOUN
admet-2861	160	26	steps	step	NOUN
admet-2861	160	27	,	,	PUNCT
admet-2861	160	28	each	each	PRON
admet-2861	160	29	of	of	ADP
admet-2861	160	30	which	which	PRON
admet-2861	160	31	introduces	introduce	VERB
admet-2861	160	32	additional	additional	ADJ
admet-2861	160	33	measurement	measurement	NOUN
admet-2861	160	34	uncertainty	uncertainty	NOUN
admet-2861	160	35	,	,	PUNCT
admet-2861	160	36	and	and	CCONJ
admet-2861	160	37	the	the	DET
admet-2861	160	38	use	use	NOUN
admet-2861	160	39	of	of	ADP
admet-2861	160	40	small	small	ADJ
admet-2861	160	41	and/or	and/or	CCONJ
admet-2861	160	42	non	non	ADJ
admet-2861	160	43	-	-	ADJ
admet-2861	160	44	standard	standard	ADJ
admet-2861	160	45	volumes	volume	NOUN
admet-2861	160	46	that	that	PRON
admet-2861	160	47	introduce	introduce	VERB
admet-2861	160	48	a	a	DET
admet-2861	160	49	larger	large	ADJ
admet-2861	160	50	relative	relative	ADJ
admet-2861	160	51	error	error	NOUN
admet-2861	160	52	.	.	PUNCT
admet-2861	161	1	additionally	additionally	ADV
admet-2861	161	2	,	,	PUNCT
admet-2861	161	3	in	in	ADP
admet-2861	161	4	other	other	ADJ
admet-2861	161	5	systems	system	NOUN
admet-2861	161	6	,	,	PUNCT
admet-2861	161	7	the	the	DET
admet-2861	161	8	dimensions	dimension	NOUN
admet-2861	161	9	of	of	ADP
admet-2861	161	10	the	the	DET
admet-2861	161	11	surface	surface	NOUN
admet-2861	161	12	through	through	ADP
admet-2861	161	13	which	which	PRON
admet-2861	161	14	dissolution	dissolution	NOUN
admet-2861	161	15	and	and	CCONJ
admet-2861	161	16	diffusion	diffusion	NOUN
admet-2861	161	17	occur	occur	VERB
admet-2861	161	18	are	be	AUX
admet-2861	161	19	smaller	small	ADJ
admet-2861	161	20	than	than	ADP
admet-2861	161	21	those	those	PRON
admet-2861	161	22	of	of	ADP
admet-2861	161	23	the	the	DET
admet-2861	161	24	aci	aci	PROPN
admet-2861	161	25	sample	sample	NOUN
admet-2861	161	26	collection	collection	NOUN
admet-2861	161	27	plates	plate	NOUN
admet-2861	161	28	,	,	PUNCT
admet-2861	161	29	making	make	VERB
admet-2861	161	30	it	it	PRON
admet-2861	161	31	impossible	impossible	ADJ
admet-2861	161	32	to	to	PART
admet-2861	161	33	use	use	VERB
admet-2861	161	34	the	the	DET
admet-2861	161	35	entire	entire	ADJ
admet-2861	161	36	sample	sample	NOUN
admet-2861	161	37	.	.	PUNCT
admet-2861	162	1	this	this	PRON
admet-2861	162	2	could	could	AUX
admet-2861	162	3	create	create	VERB
admet-2861	162	4	more	more	ADJ
admet-2861	162	5	problems	problem	NOUN
admet-2861	162	6	,	,	PUNCT
admet-2861	162	7	both	both	PRON
admet-2861	162	8	analytically	analytically	ADV
admet-2861	162	9	and	and	CCONJ
admet-2861	162	10	technically	technically	ADV
admet-2861	162	11	.	.	PUNCT
admet-2861	163	1	from	from	ADP
admet-2861	163	2	an	an	DET
admet-2861	163	3	analytical	analytical	ADJ
admet-2861	163	4	perspective	perspective	NOUN
admet-2861	163	5	,	,	PUNCT
admet-2861	163	6	lower	low	ADJ
admet-2861	163	7	concentrations	concentration	NOUN
admet-2861	163	8	mean	mean	VERB
admet-2861	163	9	reduced	reduce	VERB
admet-2861	163	10	sensitivity	sensitivity	NOUN
admet-2861	163	11	.	.	PUNCT
admet-2861	164	1	from	from	ADP
admet-2861	164	2	a	a	DET
admet-2861	164	3	technical	technical	ADJ
admet-2861	164	4	perspective	perspective	NOUN
admet-2861	164	5	,	,	PUNCT
admet-2861	164	6	dividing	divide	VERB
admet-2861	164	7	the	the	DET
admet-2861	164	8	sample	sample	NOUN
admet-2861	164	9	can	can	AUX
admet-2861	164	10	lead	lead	VERB
admet-2861	164	11	to	to	ADP
admet-2861	164	12	uneven	uneven	ADJ
admet-2861	164	13	particle	particle	NOUN
admet-2861	164	14	distribution	distribution	NOUN
admet-2861	164	15	and	and	CCONJ
admet-2861	164	16	possible	possible	ADJ
admet-2861	164	17	sample	sample	NOUN
admet-2861	164	18	loss	loss	NOUN
admet-2861	164	19	due	due	ADP
admet-2861	164	20	to	to	ADP
admet-2861	164	21	extra	extra	ADJ
admet-2861	164	22	handling	handling	NOUN
admet-2861	164	23	.	.	PUNCT
admet-2861	165	1	the	the	DET
admet-2861	165	2	disadvantage	disadvantage	NOUN
admet-2861	165	3	of	of	ADP
admet-2861	165	4	the	the	DET
admet-2861	165	5	paddle	paddle	NOUN
admet-2861	165	6	over	over	ADP
admet-2861	165	7	the	the	DET
admet-2861	165	8	disc	disc	NOUN
admet-2861	165	9	apparatus	apparatus	NOUN
admet-2861	165	10	is	be	AUX
admet-2861	165	11	the	the	DET
admet-2861	165	12	curvature	curvature	NOUN
admet-2861	165	13	at	at	ADP
admet-2861	165	14	the	the	DET
admet-2861	165	15	bottom	bottom	NOUN
admet-2861	165	16	of	of	ADP
admet-2861	165	17	the	the	DET
admet-2861	165	18	vessel	vessel	NOUN
admet-2861	165	19	,	,	PUNCT
admet-2861	165	20	which	which	PRON
admet-2861	165	21	does	do	AUX
admet-2861	165	22	not	not	PART
admet-2861	165	23	coincide	coincide	VERB
admet-2861	165	24	with	with	ADP
admet-2861	165	25	the	the	DET
admet-2861	165	26	flat	flat	ADJ
admet-2861	165	27	surface	surface	NOUN
admet-2861	165	28	of	of	ADP
admet-2861	165	29	the	the	DET
admet-2861	165	30	disk	disk	NOUN
admet-2861	165	31	or	or	CCONJ
admet-2861	165	32	membrane	membrane	NOUN
admet-2861	165	33	on	on	ADP
admet-2861	165	34	which	which	PRON
admet-2861	165	35	the	the	DET
admet-2861	165	36	particles	particle	NOUN
admet-2861	165	37	are	be	AUX
admet-2861	165	38	deposited	deposit	VERB
admet-2861	165	39	.	.	PUNCT
admet-2861	166	1	thus	thus	ADV
admet-2861	166	2	,	,	PUNCT
admet-2861	166	3	when	when	SCONJ
admet-2861	166	4	using	use	VERB
admet-2861	166	5	the	the	DET
admet-2861	166	6	disk	disk	NOUN
admet-2861	166	7	,	,	PUNCT
admet-2861	166	8	a	a	DET
admet-2861	166	9	“	"	PUNCT
admet-2861	166	10	dead	dead	ADJ
admet-2861	166	11	space	space	NOUN
admet-2861	166	12	”	"	PUNCT
admet-2861	166	13	is	be	AUX
admet-2861	166	14	created	create	VERB
admet-2861	166	15	below	below	ADP
admet-2861	166	16	it	it	PRON
admet-2861	166	17	,	,	PUNCT
admet-2861	166	18	which	which	PRON
admet-2861	166	19	is	be	AUX
admet-2861	166	20	largely	largely	ADV
admet-2861	166	21	isolated	isolate	VERB
admet-2861	166	22	from	from	ADP
admet-2861	166	23	the	the	DET
admet-2861	166	24	rest	rest	NOUN
admet-2861	166	25	of	of	ADP
admet-2861	166	26	the	the	DET
admet-2861	166	27	dissolution	dissolution	NOUN
admet-2861	166	28	medium	medium	NOUN
admet-2861	166	29	.	.	PUNCT
admet-2861	167	1	this	this	DET
admet-2861	167	2	problem	problem	NOUN
admet-2861	167	3	is	be	AUX
admet-2861	167	4	typically	typically	ADV
admet-2861	167	5	resolved	resolve	VERB
admet-2861	167	6	by	by	ADP
admet-2861	167	7	using	use	VERB
admet-2861	167	8	spacers	spacer	NOUN
admet-2861	167	9	that	that	PRON
admet-2861	167	10	create	create	VERB
admet-2861	167	11	space	space	NOUN
admet-2861	167	12	around	around	ADP
admet-2861	167	13	the	the	DET
admet-2861	167	14	edge	edge	NOUN
admet-2861	167	15	of	of	ADP
admet-2861	167	16	the	the	DET
admet-2861	167	17	disk	disk	NOUN
admet-2861	167	18	,	,	PUNCT
admet-2861	167	19	allowing	allow	VERB
admet-2861	167	20	the	the	DET
admet-2861	167	21	medium	medium	NOUN
admet-2861	167	22	to	to	PART
admet-2861	167	23	circulate	circulate	VERB
admet-2861	167	24	[	[	X
admet-2861	167	25	9,19	9,19	NUM
admet-2861	167	26	]	]	PUNCT
admet-2861	167	27	.	.	PUNCT
admet-2861	168	1	improved	improved	ADJ
admet-2861	168	2	circulation	circulation	NOUN
admet-2861	168	3	of	of	ADP
admet-2861	168	4	the	the	DET
admet-2861	168	5	medium	medium	NOUN
admet-2861	168	6	is	be	AUX
admet-2861	168	7	also	also	ADV
admet-2861	168	8	assisted	assist	VERB
admet-2861	168	9	by	by	ADP
admet-2861	168	10	higher	high	ADJ
admet-2861	168	11	rotation	rotation	NOUN
admet-2861	168	12	speeds	speed	NOUN
admet-2861	168	13	and	and	CCONJ
admet-2861	168	14	disk	disk	NOUN
admet-2861	168	15	dimensions	dimension	NOUN
admet-2861	168	16	that	that	PRON
admet-2861	168	17	do	do	AUX
admet-2861	168	18	not	not	PART
admet-2861	168	19	exceed	exceed	VERB
admet-2861	168	20	half	half	DET
admet-2861	168	21	the	the	DET
admet-2861	168	22	diameter	diameter	NOUN
admet-2861	168	23	of	of	ADP
admet-2861	168	24	the	the	DET
admet-2861	168	25	vessel	vessel	NOUN
admet-2861	168	26	for	for	ADP
admet-2861	168	27	dissolution	dissolution	NOUN
admet-2861	168	28	testing	testing	NOUN
admet-2861	168	29	.	.	PUNCT
admet-2861	169	1	since	since	SCONJ
admet-2861	169	2	the	the	DET
admet-2861	169	3	diameter	diameter	NOUN
admet-2861	169	4	of	of	ADP
admet-2861	169	5	the	the	DET
admet-2861	169	6	membrane	membrane	NOUN
admet-2861	169	7	and	and	CCONJ
admet-2861	169	8	the	the	DET
admet-2861	169	9	disk	disk	NOUN
admet-2861	169	10	holder	holder	NOUN
admet-2861	169	11	are	be	AUX
admet-2861	169	12	similar	similar	ADJ
admet-2861	169	13	to	to	ADP
admet-2861	169	14	the	the	DET
admet-2861	169	15	diameter	diameter	NOUN
admet-2861	169	16	of	of	ADP
admet-2861	169	17	the	the	DET
admet-2861	169	18	compendial	compendial	ADJ
admet-2861	169	19	dissolution	dissolution	NOUN
admet-2861	169	20	vessel	vessel	NOUN
admet-2861	169	21	,	,	PUNCT
admet-2861	169	22	it	it	PRON
admet-2861	169	23	is	be	AUX
admet-2861	169	24	necessary	necessary	ADJ
admet-2861	169	25	to	to	PART
admet-2861	169	26	use	use	VERB
admet-2861	169	27	a	a	DET
admet-2861	169	28	non	non	ADJ
admet-2861	169	29	-	-	ADJ
admet-2861	169	30	compendial	compendial	ADJ
admet-2861	169	31	vessel	vessel	NOUN
admet-2861	169	32	with	with	ADP
admet-2861	169	33	a	a	DET
admet-2861	169	34	flat	flat	ADJ
admet-2861	169	35	bottom	bottom	NOUN
admet-2861	169	36	.	.	PUNCT
admet-2861	170	1	this	this	PRON
admet-2861	170	2	reduces	reduce	VERB
admet-2861	170	3	the	the	DET
admet-2861	170	4	volume	volume	NOUN
admet-2861	170	5	of	of	ADP
admet-2861	170	6	the	the	DET
admet-2861	170	7	dead	dead	ADJ
admet-2861	170	8	space	space	NOUN
admet-2861	170	9	to	to	ADP
admet-2861	170	10	a	a	DET
admet-2861	170	11	negligible	negligible	ADJ
admet-2861	170	12	value	value	NOUN
admet-2861	170	13	.	.	PUNCT
admet-2861	171	1	also	also	ADV
admet-2861	171	2	,	,	PUNCT
admet-2861	171	3	the	the	DET
admet-2861	171	4	vessel	vessel	NOUN
admet-2861	171	5	's	's	PART
admet-2861	171	6	diameter	diameter	NOUN
admet-2861	171	7	is	be	AUX
admet-2861	171	8	slightly	slightly	ADV
admet-2861	171	9	smaller	small	ADJ
admet-2861	171	10	than	than	ADP
admet-2861	171	11	the	the	DET
admet-2861	171	12	official	official	ADJ
admet-2861	171	13	one	one	NOUN
admet-2861	171	14	,	,	PUNCT
admet-2861	171	15	and	and	CCONJ
admet-2861	171	16	the	the	DET
admet-2861	171	17	paddle	paddle	NOUN
admet-2861	171	18	position	position	NOUN
admet-2861	171	19	is	be	AUX
admet-2861	171	20	slightly	slightly	ADV
admet-2861	171	21	lower	low	ADJ
admet-2861	171	22	than	than	ADP
admet-2861	171	23	that	that	PRON
admet-2861	171	24	prescribed	prescribe	VERB
admet-2861	171	25	by	by	ADP
admet-2861	171	26	the	the	DET
admet-2861	171	27	pharmacopeias	pharmacopeia	NOUN
admet-2861	171	28	.	.	PUNCT
admet-2861	172	1	it	it	PRON
admet-2861	172	2	is	be	AUX
admet-2861	172	3	important	important	ADJ
admet-2861	172	4	to	to	PART
admet-2861	172	5	emphasize	emphasize	VERB
admet-2861	172	6	here	here	ADV
admet-2861	172	7	that	that	SCONJ
admet-2861	172	8	the	the	DET
admet-2861	172	9	lower	low	ADJ
admet-2861	172	10	position	position	NOUN
admet-2861	172	11	of	of	ADP
admet-2861	172	12	the	the	DET
admet-2861	172	13	paddle	paddle	NOUN
admet-2861	172	14	is	be	AUX
admet-2861	172	15	conditioned	condition	VERB
admet-2861	172	16	by	by	ADP
admet-2861	172	17	the	the	DET
admet-2861	172	18	simultaneous	simultaneous	ADJ
admet-2861	172	19	need	need	NOUN
admet-2861	172	20	for	for	SCONJ
admet-2861	172	21	it	it	PRON
admet-2861	172	22	to	to	PART
admet-2861	172	23	be	be	AUX
admet-2861	172	24	wholly	wholly	ADV
admet-2861	172	25	immersed	immerse	VERB
admet-2861	172	26	in	in	ADP
admet-2861	172	27	the	the	DET
admet-2861	172	28	dissolution	dissolution	NOUN
admet-2861	172	29	medium	medium	NOUN
admet-2861	172	30	,	,	PUNCT
admet-2861	172	31	whose	whose	DET
admet-2861	172	32	volume	volume	NOUN
admet-2861	172	33	was	be	AUX
admet-2861	172	34	300	300	NUM
admet-2861	172	35	ml	ml	NOUN
admet-2861	172	36	.	.	PUNCT
admet-2861	173	1	the	the	DET
admet-2861	173	2	detailed	detailed	ADJ
admet-2861	173	3	dimensions	dimension	NOUN
admet-2861	173	4	of	of	ADP
admet-2861	173	5	the	the	DET
admet-2861	173	6	apparatus	apparatus	NOUN
admet-2861	173	7	used	use	VERB
admet-2861	173	8	are	be	AUX
admet-2861	173	9	given	give	VERB
admet-2861	173	10	in	in	ADP
admet-2861	173	11	figure	figure	NOUN
admet-2861	173	12	1	1	NUM
admet-2861	173	13	.	.	PUNCT
admet-2861	173	14	sampling	sampling	NOUN
admet-2861	173	15	was	be	AUX
admet-2861	173	16	performed	perform	VERB
admet-2861	173	17	from	from	ADP
admet-2861	173	18	a	a	DET
admet-2861	173	19	point	point	NOUN
admet-2861	173	20	approximately	approximately	ADV
admet-2861	173	21	25	25	NUM
admet-2861	173	22	mm	mm	NOUN
admet-2861	173	23	from	from	ADP
admet-2861	173	24	the	the	DET
admet-2861	173	25	bottom	bottom	NOUN
admet-2861	173	26	of	of	ADP
admet-2861	173	27	the	the	DET
admet-2861	173	28	vessel	vessel	NOUN
admet-2861	173	29	and	and	CCONJ
admet-2861	173	30	5	5	NUM
admet-2861	173	31	mm	mm	NOUN
admet-2861	173	32	from	from	ADP
admet-2861	173	33	the	the	DET
admet-2861	173	34	vessel	vessel	NOUN
admet-2861	173	35	wall	wall	NOUN
admet-2861	173	36	.	.	PUNCT
admet-2861	174	1	the	the	DET
admet-2861	174	2	reason	reason	NOUN
admet-2861	174	3	for	for	ADP
admet-2861	174	4	this	this	PRON
admet-2861	174	5	is	be	AUX
admet-2861	174	6	the	the	DET
admet-2861	174	7	low	low	ADJ
admet-2861	174	8	liquid	liquid	ADJ
admet-2861	174	9	level	level	NOUN
admet-2861	174	10	above	above	ADP
admet-2861	174	11	the	the	DET
admet-2861	174	12	admet	admet	PROPN
admet-2861	174	13	&	&	CCONJ
admet-2861	174	14	dmpk	dmpk	PROPN
admet-2861	174	15	13	13	NUM
admet-2861	174	16	(	(	PUNCT
admet-2861	174	17	)	)	PUNCT
admet-2861	174	18	(	(	PUNCT
admet-2861	174	19	2025	2025	NUM
admet-2861	174	20	)	)	PUNCT
admet-2861	174	21	2861	2861	NUM
admet-2861	174	22	development	development	NOUN
admet-2861	174	23	of	of	ADP
admet-2861	174	24	a	a	DET
admet-2861	174	25	biorelevant	biorelevant	ADJ
admet-2861	174	26	dissolution	dissolution	NOUN
admet-2861	174	27	method	method	NOUN
admet-2861	174	28	for	for	ADP
admet-2861	174	29	inhalation	inhalation	NOUN
admet-2861	174	30	products	product	NOUN
admet-2861	174	31	doi	doi	NOUN
admet-2861	174	32	:	:	PUNCT
admet-2861	174	33	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	174	34	9	9	NUM
admet-2861	174	35	paddles	paddle	NOUN
admet-2861	174	36	and	and	CCONJ
admet-2861	174	37	the	the	DET
admet-2861	174	38	narrow	narrow	ADJ
admet-2861	174	39	space	space	NOUN
admet-2861	174	40	between	between	ADP
admet-2861	174	41	the	the	DET
admet-2861	174	42	rotating	rotate	VERB
admet-2861	174	43	paddles	paddle	NOUN
admet-2861	174	44	and	and	CCONJ
admet-2861	174	45	the	the	DET
admet-2861	174	46	vessel	vessel	NOUN
admet-2861	174	47	wall	wall	NOUN
admet-2861	174	48	.	.	PUNCT
admet-2861	175	1	therefore	therefore	ADV
admet-2861	175	2	,	,	PUNCT
admet-2861	175	3	it	it	PRON
admet-2861	175	4	was	be	AUX
admet-2861	175	5	not	not	PART
admet-2861	175	6	possible	possible	ADJ
admet-2861	175	7	to	to	PART
admet-2861	175	8	perform	perform	VERB
admet-2861	175	9	sampling	sample	VERB
admet-2861	175	10	from	from	ADP
admet-2861	175	11	a	a	DET
admet-2861	175	12	location	location	NOUN
admet-2861	175	13	equivalent	equivalent	ADJ
admet-2861	175	14	to	to	ADP
admet-2861	175	15	that	that	PRON
admet-2861	175	16	prescribed	prescribe	VERB
admet-2861	175	17	in	in	ADP
admet-2861	175	18	the	the	DET
admet-2861	175	19	pharmacopoeias	pharmacopoeia	NOUN
admet-2861	175	20	.	.	PUNCT
admet-2861	176	1	pharmacopoeias	pharmacopoeia	NOUN
admet-2861	176	2	do	do	AUX
admet-2861	176	3	not	not	PART
admet-2861	176	4	provide	provide	VERB
admet-2861	176	5	a	a	DET
admet-2861	176	6	general	general	ADJ
admet-2861	176	7	guideline	guideline	NOUN
admet-2861	176	8	for	for	ADP
admet-2861	176	9	the	the	DET
admet-2861	176	10	paddle	paddle	NOUN
admet-2861	176	11	rotational	rotational	ADJ
admet-2861	176	12	speed	speed	NOUN
admet-2861	176	13	in	in	ADP
admet-2861	176	14	the	the	DET
admet-2861	176	15	dissolution	dissolution	NOUN
admet-2861	176	16	test	test	NOUN
admet-2861	176	17	.	.	PUNCT
admet-2861	177	1	the	the	DET
admet-2861	177	2	values	value	NOUN
admet-2861	177	3	for	for	ADP
admet-2861	177	4	the	the	DET
admet-2861	177	5	rotation	rotation	NOUN
admet-2861	177	6	speed	speed	NOUN
admet-2861	177	7	are	be	AUX
admet-2861	177	8	given	give	VERB
admet-2861	177	9	in	in	ADP
admet-2861	177	10	individual	individual	ADJ
admet-2861	177	11	monographs	monograph	NOUN
admet-2861	177	12	of	of	ADP
admet-2861	177	13	the	the	DET
admet-2861	177	14	products	product	NOUN
admet-2861	177	15	by	by	ADP
admet-2861	177	16	the	the	DET
admet-2861	177	17	united	united	PROPN
admet-2861	177	18	states	states	PROPN
admet-2861	177	19	pharmacopoeia	pharmacopoeia	PROPN
admet-2861	177	20	,	,	PUNCT
admet-2861	177	21	and	and	CCONJ
admet-2861	177	22	the	the	DET
admet-2861	177	23	most	most	ADV
admet-2861	177	24	commonly	commonly	ADV
admet-2861	177	25	used	use	VERB
admet-2861	177	26	speeds	speed	NOUN
admet-2861	177	27	are	be	AUX
admet-2861	177	28	50	50	NUM
admet-2861	177	29	,	,	PUNCT
admet-2861	177	30	75	75	NUM
admet-2861	177	31	and	and	CCONJ
admet-2861	177	32	100	100	NUM
admet-2861	177	33	rpm	rpm	NOUN
admet-2861	177	34	.	.	PUNCT
admet-2861	178	1	preliminary	preliminary	ADJ
admet-2861	178	2	experiments	experiment	NOUN
admet-2861	178	3	were	be	AUX
admet-2861	178	4	conducted	conduct	VERB
admet-2861	178	5	with	with	ADP
admet-2861	178	6	product	product	NOUN
admet-2861	178	7	b3	b3	NOUN
admet-2861	178	8	,	,	PUNCT
admet-2861	178	9	which	which	PRON
admet-2861	178	10	contains	contain	VERB
admet-2861	178	11	bdp	bdp	PROPN
admet-2861	178	12	,	,	PUNCT
admet-2861	178	13	at	at	ADP
admet-2861	178	14	a	a	DET
admet-2861	178	15	speed	speed	NOUN
admet-2861	178	16	of	of	ADP
admet-2861	178	17	50	50	NUM
admet-2861	178	18	rpm	rpm	NOUN
admet-2861	178	19	.	.	PUNCT
admet-2861	179	1	at	at	ADP
admet-2861	179	2	a	a	DET
admet-2861	179	3	paddle	paddle	NOUN
admet-2861	179	4	speed	speed	NOUN
admet-2861	179	5	of	of	ADP
admet-2861	179	6	50	50	NUM
admet-2861	179	7	rpm	rpm	NOUN
admet-2861	179	8	,	,	PUNCT
admet-2861	179	9	significant	significant	ADJ
admet-2861	179	10	variations	variation	NOUN
admet-2861	179	11	were	be	AUX
admet-2861	179	12	observed	observe	VERB
admet-2861	179	13	between	between	ADP
admet-2861	179	14	the	the	DET
admet-2861	179	15	results	result	NOUN
admet-2861	179	16	of	of	ADP
admet-2861	179	17	repeated	repeat	VERB
admet-2861	179	18	experiments	experiment	NOUN
admet-2861	179	19	,	,	PUNCT
admet-2861	179	20	especially	especially	ADV
admet-2861	179	21	during	during	ADP
admet-2861	179	22	the	the	DET
admet-2861	179	23	first	first	ADJ
admet-2861	179	24	hour	hour	NOUN
admet-2861	179	25	of	of	ADP
admet-2861	179	26	the	the	DET
admet-2861	179	27	test	test	NOUN
admet-2861	179	28	.	.	PUNCT
admet-2861	180	1	by	by	ADP
admet-2861	180	2	increasing	increase	VERB
admet-2861	180	3	the	the	DET
admet-2861	180	4	paddle	paddle	NOUN
admet-2861	180	5	speed	speed	NOUN
admet-2861	180	6	to	to	ADP
admet-2861	180	7	100	100	NUM
admet-2861	180	8	,	,	PUNCT
admet-2861	180	9	the	the	DET
admet-2861	180	10	variation	variation	NOUN
admet-2861	180	11	in	in	ADP
admet-2861	180	12	the	the	DET
admet-2861	180	13	results	result	NOUN
admet-2861	180	14	disappeared	disappear	VERB
admet-2861	180	15	,	,	PUNCT
admet-2861	180	16	and	and	CCONJ
admet-2861	180	17	the	the	DET
admet-2861	180	18	results	result	NOUN
admet-2861	180	19	became	become	VERB
admet-2861	180	20	homogeneous	homogeneous	ADJ
admet-2861	180	21	and	and	CCONJ
admet-2861	180	22	reproducible	reproducible	ADJ
admet-2861	180	23	(	(	PUNCT
admet-2861	180	24	figure	figure	NOUN
admet-2861	180	25	4	4	NUM
admet-2861	180	26	)	)	PUNCT
admet-2861	180	27	.	.	PUNCT
admet-2861	181	1	thus	thus	ADV
admet-2861	181	2	,	,	PUNCT
admet-2861	181	3	the	the	DET
admet-2861	181	4	increase	increase	NOUN
admet-2861	181	5	in	in	ADP
admet-2861	181	6	media	medium	NOUN
admet-2861	181	7	homogenization	homogenization	NOUN
admet-2861	181	8	was	be	AUX
admet-2861	181	9	achieved	achieve	VERB
admet-2861	181	10	by	by	ADP
admet-2861	181	11	increasing	increase	VERB
admet-2861	181	12	the	the	DET
admet-2861	181	13	rotation	rotation	NOUN
admet-2861	181	14	speed	speed	NOUN
admet-2861	181	15	to	to	ADP
admet-2861	181	16	100	100	NUM
admet-2861	181	17	rpm	rpm	NOUN
admet-2861	181	18	.	.	PUNCT
admet-2861	182	1	all	all	DET
admet-2861	182	2	experiments	experiment	NOUN
admet-2861	182	3	were	be	AUX
admet-2861	182	4	performed	perform	VERB
admet-2861	182	5	at	at	ADP
admet-2861	182	6	a	a	DET
admet-2861	182	7	rotation	rotation	NOUN
admet-2861	182	8	speed	speed	NOUN
admet-2861	182	9	of	of	ADP
admet-2861	182	10	100	100	NUM
admet-2861	182	11	rpm	rpm	NOUN
admet-2861	182	12	to	to	PART
admet-2861	182	13	standardize	standardize	VERB
admet-2861	182	14	the	the	DET
admet-2861	182	15	assay	assay	NOUN
admet-2861	182	16	.	.	PUNCT
admet-2861	183	1	although	although	SCONJ
admet-2861	183	2	the	the	DET
admet-2861	183	3	dissolution	dissolution	NOUN
admet-2861	183	4	medium	medium	NOUN
admet-2861	183	5	used	use	VERB
admet-2861	183	6	for	for	ADP
admet-2861	183	7	sx	sx	NOUN
admet-2861	183	8	testing	testing	NOUN
admet-2861	183	9	did	do	AUX
admet-2861	183	10	not	not	PART
admet-2861	183	11	contain	contain	VERB
admet-2861	183	12	sds	sds	NOUN
admet-2861	183	13	and	and	CCONJ
admet-2861	183	14	theoretically	theoretically	ADV
admet-2861	183	15	should	should	AUX
admet-2861	183	16	not	not	PART
admet-2861	183	17	have	have	AUX
admet-2861	183	18	caused	cause	VERB
admet-2861	183	19	micelle	micelle	NOUN
admet-2861	183	20	formation	formation	NOUN
admet-2861	183	21	and	and	CCONJ
admet-2861	183	22	variation	variation	NOUN
admet-2861	183	23	in	in	ADP
admet-2861	183	24	results	result	NOUN
admet-2861	183	25	,	,	PUNCT
admet-2861	183	26	the	the	DET
admet-2861	183	27	rotation	rotation	NOUN
admet-2861	183	28	speed	speed	NOUN
admet-2861	183	29	was	be	AUX
admet-2861	183	30	kept	keep	VERB
admet-2861	183	31	at	at	ADP
admet-2861	183	32	100	100	NUM
admet-2861	183	33	rpm	rpm	NOUN
admet-2861	183	34	for	for	ADP
admet-2861	183	35	more	more	ADV
admet-2861	183	36	intensive	intensive	ADJ
admet-2861	183	37	mixing	mixing	NOUN
admet-2861	183	38	.	.	PUNCT
admet-2861	184	1	additional	additional	ADJ
admet-2861	184	2	sources	source	NOUN
admet-2861	184	3	of	of	ADP
admet-2861	184	4	variability	variability	NOUN
admet-2861	184	5	in	in	ADP
admet-2861	184	6	dissolution	dissolution	NOUN
admet-2861	184	7	test	test	NOUN
admet-2861	184	8	results	result	NOUN
admet-2861	184	9	for	for	ADP
admet-2861	184	10	inhalation	inhalation	NOUN
admet-2861	184	11	products	product	NOUN
admet-2861	184	12	,	,	PUNCT
admet-2861	184	13	related	relate	VERB
admet-2861	184	14	to	to	ADP
admet-2861	184	15	sample	sample	NOUN
admet-2861	184	16	size	size	NOUN
admet-2861	184	17	,	,	PUNCT
admet-2861	184	18	include	include	VERB
admet-2861	184	19	interactions	interaction	NOUN
admet-2861	184	20	with	with	ADP
admet-2861	184	21	the	the	DET
admet-2861	184	22	membrane	membrane	NOUN
admet-2861	184	23	and	and	CCONJ
admet-2861	184	24	limited	limited	ADJ
admet-2861	184	25	solubility	solubility	NOUN
admet-2861	184	26	of	of	ADP
admet-2861	184	27	the	the	DET
admet-2861	184	28	active	active	ADJ
admet-2861	184	29	substance	substance	NOUN
admet-2861	184	30	in	in	ADP
admet-2861	184	31	the	the	DET
admet-2861	184	32	selected	select	VERB
admet-2861	184	33	medium	medium	NOUN
admet-2861	184	34	.	.	PUNCT
admet-2861	185	1	problems	problem	NOUN
admet-2861	185	2	with	with	ADP
admet-2861	185	3	solubility	solubility	NOUN
admet-2861	185	4	are	be	AUX
admet-2861	185	5	common	common	ADJ
admet-2861	185	6	for	for	ADP
admet-2861	185	7	substances	substance	NOUN
admet-2861	185	8	with	with	ADP
admet-2861	185	9	low	low	ADJ
admet-2861	185	10	solubility	solubility	NOUN
admet-2861	185	11	,	,	PUNCT
admet-2861	185	12	and	and	CCONJ
admet-2861	185	13	the	the	DET
admet-2861	185	14	variability	variability	NOUN
admet-2861	185	15	will	will	AUX
admet-2861	185	16	be	be	AUX
admet-2861	185	17	more	more	ADV
admet-2861	185	18	pronounced	pronounce	VERB
admet-2861	185	19	as	as	ADP
admet-2861	185	20	the	the	DET
admet-2861	185	21	sample	sample	NOUN
admet-2861	185	22	size	size	NOUN
admet-2861	185	23	increases	increase	NOUN
admet-2861	185	24	,	,	PUNCT
admet-2861	185	25	where	where	SCONJ
admet-2861	185	26	the	the	DET
admet-2861	185	27	saturation	saturation	NOUN
admet-2861	185	28	concentration	concentration	NOUN
admet-2861	185	29	of	of	ADP
admet-2861	185	30	the	the	DET
admet-2861	185	31	solution	solution	NOUN
admet-2861	185	32	is	be	AUX
admet-2861	185	33	reached	reach	VERB
admet-2861	185	34	more	more	ADV
admet-2861	185	35	quickly	quickly	ADV
admet-2861	185	36	.	.	PUNCT
admet-2861	186	1	issues	issue	NOUN
admet-2861	186	2	related	relate	VERB
admet-2861	186	3	to	to	ADP
admet-2861	186	4	membrane	membrane	NOUN
admet-2861	186	5	interactions	interaction	NOUN
admet-2861	186	6	are	be	AUX
admet-2861	186	7	typically	typically	ADV
admet-2861	186	8	the	the	DET
admet-2861	186	9	result	result	NOUN
admet-2861	186	10	of	of	ADP
admet-2861	186	11	drug	drug	NOUN
admet-2861	186	12	adsorption	adsorption	NOUN
admet-2861	186	13	on	on	ADP
admet-2861	186	14	the	the	DET
admet-2861	186	15	membrane	membrane	NOUN
admet-2861	186	16	.	.	PUNCT
admet-2861	187	1	figure	figure	NOUN
admet-2861	187	2	4	4	NUM
admet-2861	187	3	.	.	PUNCT
admet-2861	187	4	effect	effect	NOUN
admet-2861	187	5	of	of	ADP
admet-2861	187	6	agitation	agitation	NOUN
admet-2861	187	7	(	(	PUNCT
admet-2861	187	8	or	or	CCONJ
admet-2861	187	9	paddle	paddle	NOUN
admet-2861	187	10	speed	speed	NOUN
admet-2861	187	11	)	)	PUNCT
admet-2861	187	12	on	on	ADP
admet-2861	187	13	bdp	bdp	PROPN
admet-2861	187	14	dissolution	dissolution	PROPN
admet-2861	187	15	rate	rate	NOUN
admet-2861	187	16	from	from	ADP
admet-2861	187	17	sample	sample	NOUN
admet-2861	187	18	b3	b3	PROPN
admet-2861	187	19	,	,	PUNCT
admet-2861	187	20	designations	designation	NOUN
admet-2861	187	21	1	1	NUM
admet-2861	187	22	and	and	CCONJ
admet-2861	187	23	2	2	NUM
admet-2861	187	24	refer	refer	VERB
admet-2861	187	25	to	to	ADP
admet-2861	187	26	two	two	NUM
admet-2861	187	27	separate	separate	ADJ
admet-2861	187	28	experiments	experiment	NOUN
admet-2861	187	29	since	since	SCONJ
admet-2861	187	30	the	the	DET
admet-2861	187	31	used	use	VERB
admet-2861	187	32	membrane	membrane	NOUN
admet-2861	187	33	is	be	AUX
admet-2861	187	34	highly	highly	ADV
admet-2861	187	35	hydrophilic	hydrophilic	ADJ
admet-2861	187	36	,	,	PUNCT
admet-2861	187	37	hydrophilic	hydrophilic	ADJ
admet-2861	187	38	and	and	CCONJ
admet-2861	187	39	ionic	ionic	ADJ
admet-2861	187	40	interactions	interaction	NOUN
admet-2861	187	41	would	would	AUX
admet-2861	187	42	dominate	dominate	VERB
admet-2861	187	43	the	the	DET
admet-2861	187	44	adsorption	adsorption	NOUN
admet-2861	187	45	process	process	NOUN
admet-2861	187	46	,	,	PUNCT
admet-2861	187	47	and	and	CCONJ
admet-2861	187	48	these	these	DET
admet-2861	187	49	interactions	interaction	NOUN
admet-2861	187	50	would	would	AUX
admet-2861	187	51	be	be	AUX
admet-2861	187	52	more	more	ADV
admet-2861	187	53	pronounced	pronounced	ADJ
admet-2861	187	54	for	for	ADP
admet-2861	187	55	substances	substance	NOUN
admet-2861	187	56	that	that	PRON
admet-2861	187	57	are	be	AUX
admet-2861	187	58	highly	highly	ADV
admet-2861	187	59	soluble	soluble	ADJ
admet-2861	187	60	in	in	ADP
admet-2861	187	61	water	water	NOUN
admet-2861	187	62	.	.	PUNCT
admet-2861	188	1	because	because	SCONJ
admet-2861	188	2	membranes	membrane	NOUN
admet-2861	188	3	should	should	AUX
admet-2861	188	4	have	have	VERB
admet-2861	188	5	a	a	DET
admet-2861	188	6	specific	specific	ADJ
admet-2861	188	7	adsorption	adsorption	NOUN
admet-2861	188	8	capacity	capacity	NOUN
admet-2861	188	9	,	,	PUNCT
admet-2861	188	10	the	the	DET
admet-2861	188	11	relative	relative	ADJ
admet-2861	188	12	error	error	NOUN
admet-2861	188	13	is	be	AUX
admet-2861	188	14	expected	expect	VERB
admet-2861	188	15	to	to	PART
admet-2861	188	16	increase	increase	VERB
admet-2861	188	17	as	as	SCONJ
admet-2861	188	18	the	the	DET
admet-2861	188	19	sample	sample	NOUN
admet-2861	188	20	size	size	NOUN
admet-2861	188	21	is	be	AUX
admet-2861	188	22	reduced	reduce	VERB
admet-2861	188	23	.	.	PUNCT
admet-2861	189	1	the	the	DET
admet-2861	189	2	influence	influence	NOUN
admet-2861	189	3	of	of	ADP
admet-2861	189	4	the	the	DET
admet-2861	189	5	amount	amount	NOUN
admet-2861	189	6	of	of	ADP
admet-2861	189	7	active	active	ADJ
admet-2861	189	8	substance	substance	NOUN
admet-2861	189	9	on	on	ADP
admet-2861	189	10	the	the	DET
admet-2861	189	11	dissolution	dissolution	NOUN
admet-2861	189	12	rate	rate	NOUN
admet-2861	189	13	was	be	AUX
admet-2861	189	14	examined	examine	VERB
admet-2861	189	15	by	by	ADP
admet-2861	189	16	varying	vary	VERB
admet-2861	189	17	the	the	DET
admet-2861	189	18	number	number	NOUN
admet-2861	189	19	of	of	ADP
admet-2861	189	20	doses	dose	NOUN
admet-2861	189	21	or	or	CCONJ
admet-2861	189	22	device	device	NOUN
admet-2861	189	23	activations	activation	NOUN
admet-2861	189	24	used	use	VERB
admet-2861	189	25	to	to	PART
admet-2861	189	26	prepare	prepare	VERB
admet-2861	189	27	the	the	DET
admet-2861	189	28	sample	sample	NOUN
admet-2861	189	29	,	,	PUNCT
admet-2861	189	30	depending	depend	VERB
admet-2861	189	31	on	on	ADP
admet-2861	189	32	the	the	DET
admet-2861	189	33	reasoning	reasoning	NOUN
admet-2861	189	34	,	,	PUNCT
admet-2861	189	35	which	which	DET
admet-2861	189	36	factor	factor	NOUN
admet-2861	189	37	is	be	AUX
admet-2861	189	38	most	most	ADV
admet-2861	189	39	problematic	problematic	ADJ
admet-2861	189	40	for	for	ADP
admet-2861	189	41	highor	highor	NOUN
admet-2861	189	42	low	low	ADJ
admet-2861	189	43	-	-	PUNCT
admet-2861	189	44	solubility	solubility	NOUN
admet-2861	189	45	substances	substance	NOUN
admet-2861	189	46	.	.	PUNCT
admet-2861	190	1	the	the	DET
admet-2861	190	2	number	number	NOUN
admet-2861	190	3	of	of	ADP
admet-2861	190	4	doses	dose	NOUN
admet-2861	190	5	was	be	AUX
admet-2861	190	6	varied	vary	VERB
admet-2861	190	7	by	by	ADP
admet-2861	190	8	±50	±50	NOUN
admet-2861	190	9	%	%	NOUN
admet-2861	190	10	relative	relative	ADJ
admet-2861	190	11	to	to	ADP
admet-2861	190	12	the	the	DET
admet-2861	190	13	selected	select	VERB
admet-2861	190	14	reference	reference	NOUN
admet-2861	190	15	sample	sample	NOUN
admet-2861	190	16	size	size	NOUN
admet-2861	190	17	of	of	ADP
admet-2861	190	18	10	10	NUM
admet-2861	190	19	doses	dose	NOUN
admet-2861	190	20	.	.	PUNCT
admet-2861	191	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	191	2	a.	a.	PROPN
admet-2861	191	3	elezović	elezović	PROPN
admet-2861	191	4	et	et	PROPN
admet-2861	191	5	al	al	PROPN
admet-2861	191	6	.	.	PROPN
admet-2861	191	7	admet	admet	PROPN
admet-2861	191	8	&	&	CCONJ
admet-2861	191	9	dmpk	dmpk	PROPN
admet-2861	191	10	13(5	13(5	NUM
admet-2861	191	11	)	)	PUNCT
admet-2861	191	12	(	(	PUNCT
admet-2861	191	13	2025	2025	NUM
admet-2861	191	14	)	)	PUNCT
admet-2861	191	15	2861	2861	NUM
admet-2861	191	16	10	10	NUM
admet-2861	191	17	since	since	SCONJ
admet-2861	191	18	sx	sx	PROPN
admet-2861	191	19	has	have	VERB
admet-2861	191	20	relatively	relatively	ADV
admet-2861	191	21	good	good	ADJ
admet-2861	191	22	solubility	solubility	NOUN
admet-2861	191	23	,	,	PUNCT
admet-2861	191	24	it	it	PRON
admet-2861	191	25	was	be	AUX
admet-2861	191	26	expected	expect	VERB
admet-2861	191	27	that	that	SCONJ
admet-2861	191	28	the	the	DET
admet-2861	191	29	primary	primary	ADJ
admet-2861	191	30	reason	reason	NOUN
admet-2861	191	31	for	for	ADP
admet-2861	191	32	the	the	DET
admet-2861	191	33	variation	variation	NOUN
admet-2861	191	34	in	in	ADP
admet-2861	191	35	the	the	DET
admet-2861	191	36	results	result	NOUN
admet-2861	191	37	could	could	AUX
admet-2861	191	38	be	be	AUX
admet-2861	191	39	adsorption	adsorption	NOUN
admet-2861	191	40	on	on	ADP
admet-2861	191	41	the	the	DET
admet-2861	191	42	membrane	membrane	NOUN
admet-2861	191	43	during	during	ADP
admet-2861	191	44	the	the	DET
admet-2861	191	45	test	test	NOUN
admet-2861	191	46	.	.	PUNCT
admet-2861	192	1	therefore	therefore	ADV
admet-2861	192	2	,	,	PUNCT
admet-2861	192	3	the	the	DET
admet-2861	192	4	influence	influence	NOUN
admet-2861	192	5	of	of	ADP
admet-2861	192	6	drug	drug	NOUN
admet-2861	192	7	loading	loading	NOUN
admet-2861	192	8	was	be	AUX
admet-2861	192	9	evaluated	evaluate	VERB
admet-2861	192	10	by	by	ADP
admet-2861	192	11	comparing	compare	VERB
admet-2861	192	12	the	the	DET
admet-2861	192	13	dissolution	dissolution	ADJ
admet-2861	192	14	rate	rate	NOUN
admet-2861	192	15	of	of	ADP
admet-2861	192	16	the	the	DET
admet-2861	192	17	sample	sample	NOUN
admet-2861	192	18	(	(	PUNCT
admet-2861	192	19	product	product	NOUN
admet-2861	192	20	s2	s2	PROPN
admet-2861	192	21	,	,	PUNCT
admet-2861	192	22	which	which	PRON
admet-2861	192	23	contains	contain	VERB
admet-2861	192	24	only	only	ADV
admet-2861	192	25	sx	sx	PROPN
admet-2861	192	26	)	)	PUNCT
admet-2861	192	27	with	with	ADP
admet-2861	192	28	a	a	DET
admet-2861	192	29	smaller	small	ADJ
admet-2861	192	30	number	number	NOUN
admet-2861	192	31	of	of	ADP
admet-2861	192	32	doses	dose	NOUN
admet-2861	192	33	,	,	PUNCT
admet-2861	192	34	i.e.	i.e.	X
admet-2861	192	35	5	5	NUM
admet-2861	192	36	doses	dose	NOUN
admet-2861	192	37	(	(	PUNCT
admet-2861	192	38	figure	figure	NOUN
admet-2861	192	39	5	5	NUM
admet-2861	192	40	)	)	PUNCT
admet-2861	192	41	.	.	PUNCT
admet-2861	193	1	figure	figure	NOUN
admet-2861	193	2	5	5	NUM
admet-2861	193	3	.	.	PUNCT
admet-2861	194	1	dissolution	dissolution	ADJ
admet-2861	194	2	profiles	profile	NOUN
admet-2861	194	3	of	of	ADP
admet-2861	194	4	salmeterol	salmeterol	NOUN
admet-2861	194	5	-	-	PUNCT
admet-2861	194	6	xinafoate	xinafoate	ADJ
admet-2861	194	7	from	from	ADP
admet-2861	194	8	samples	sample	NOUN
admet-2861	194	9	containing	contain	VERB
admet-2861	194	10	5	5	NUM
admet-2861	194	11	and	and	CCONJ
admet-2861	194	12	10	10	NUM
admet-2861	194	13	doses	dose	NOUN
admet-2861	194	14	of	of	ADP
admet-2861	194	15	product	product	NOUN
admet-2861	194	16	s2	s2	VERB
admet-2861	194	17	the	the	DET
admet-2861	194	18	difference	difference	NOUN
admet-2861	194	19	between	between	ADP
admet-2861	194	20	the	the	DET
admet-2861	194	21	dissolution	dissolution	NOUN
admet-2861	194	22	profiles	profile	NOUN
admet-2861	194	23	was	be	AUX
admet-2861	194	24	examined	examine	VERB
admet-2861	194	25	using	use	VERB
admet-2861	194	26	model	model	NOUN
admet-2861	194	27	-	-	PUNCT
admet-2861	194	28	independent	independent	ADJ
admet-2861	194	29	methods	method	NOUN
admet-2861	194	30	calculating	calculate	VERB
admet-2861	194	31	difference	difference	NOUN
admet-2861	194	32	and	and	CCONJ
admet-2861	194	33	similarity	similarity	NOUN
admet-2861	194	34	factors	factor	NOUN
admet-2861	194	35	.	.	PUNCT
admet-2861	195	1	calculated	calculate	VERB
admet-2861	195	2	factors	factor	NOUN
admet-2861	195	3	suggest	suggest	VERB
admet-2861	195	4	that	that	SCONJ
admet-2861	195	5	the	the	DET
admet-2861	195	6	obtained	obtain	VERB
admet-2861	195	7	results	result	NOUN
admet-2861	195	8	were	be	AUX
admet-2861	195	9	comparable	comparable	ADJ
admet-2861	195	10	(	(	PUNCT
admet-2861	195	11	f1	f1	NOUN
admet-2861	195	12	=	=	SYM
admet-2861	195	13	11.6	11.6	NUM
admet-2861	195	14	,	,	PUNCT
admet-2861	195	15	f2	f2	PROPN
admet-2861	195	16	=	=	NOUN
admet-2861	195	17	53.8	53.8	NUM
admet-2861	195	18	)	)	PUNCT
admet-2861	195	19	.	.	PUNCT
admet-2861	196	1	a	a	DET
admet-2861	196	2	critical	critical	ADJ
admet-2861	196	3	parameter	parameter	NOUN
admet-2861	196	4	for	for	ADP
admet-2861	196	5	dissolution	dissolution	ADJ
admet-2861	196	6	rate	rate	NOUN
admet-2861	196	7	analysis	analysis	NOUN
admet-2861	196	8	of	of	ADP
admet-2861	196	9	bdp	bdp	PROPN
admet-2861	196	10	is	be	AUX
admet-2861	196	11	its	its	PRON
admet-2861	196	12	solubility	solubility	NOUN
admet-2861	196	13	.	.	PUNCT
admet-2861	197	1	although	although	SCONJ
admet-2861	197	2	the	the	DET
admet-2861	197	3	media	medium	NOUN
admet-2861	197	4	volume	volume	NOUN
admet-2861	197	5	was	be	AUX
admet-2861	197	6	sufficient	sufficient	ADJ
admet-2861	197	7	to	to	PART
admet-2861	197	8	satisfy	satisfy	VERB
admet-2861	197	9	the	the	DET
admet-2861	197	10	sink	sink	NOUN
admet-2861	197	11	conditions	condition	NOUN
admet-2861	197	12	,	,	PUNCT
admet-2861	197	13	during	during	ADP
admet-2861	197	14	the	the	DET
admet-2861	197	15	analysis	analysis	NOUN
admet-2861	197	16	,	,	PUNCT
admet-2861	197	17	the	the	DET
admet-2861	197	18	bdp	bdp	PROPN
admet-2861	197	19	particles	particle	NOUN
admet-2861	197	20	were	be	AUX
admet-2861	197	21	found	find	VERB
admet-2861	197	22	to	to	PART
admet-2861	197	23	be	be	AUX
admet-2861	197	24	located	locate	VERB
admet-2861	197	25	in	in	ADP
admet-2861	197	26	the	the	DET
admet-2861	197	27	narrow	narrow	ADJ
admet-2861	197	28	capillary	capillary	ADJ
admet-2861	197	29	space	space	NOUN
admet-2861	197	30	between	between	ADP
admet-2861	197	31	the	the	DET
admet-2861	197	32	agar	agar	NOUN
admet-2861	197	33	membrane	membrane	NOUN
admet-2861	197	34	and	and	CCONJ
admet-2861	197	35	the	the	DET
admet-2861	197	36	metal	metal	NOUN
admet-2861	197	37	plate	plate	NOUN
admet-2861	197	38	of	of	ADP
admet-2861	197	39	the	the	DET
admet-2861	197	40	cascade	cascade	NOUN
admet-2861	197	41	impactor	impactor	NOUN
admet-2861	197	42	.	.	PUNCT
admet-2861	198	1	to	to	PART
admet-2861	198	2	diffuse	diffuse	VERB
admet-2861	198	3	further	far	ADV
admet-2861	198	4	through	through	ADP
admet-2861	198	5	the	the	DET
admet-2861	198	6	polysaccharide	polysaccharide	NOUN
admet-2861	198	7	membrane	membrane	NOUN
admet-2861	198	8	,	,	PUNCT
admet-2861	198	9	they	they	PRON
admet-2861	198	10	must	must	AUX
admet-2861	198	11	first	first	ADV
admet-2861	198	12	dissolve	dissolve	VERB
admet-2861	198	13	in	in	ADP
admet-2861	198	14	the	the	DET
admet-2861	198	15	small	small	ADJ
admet-2861	198	16	volume	volume	NOUN
admet-2861	198	17	of	of	ADP
admet-2861	198	18	liquid	liquid	NOUN
admet-2861	198	19	surrounding	surround	VERB
admet-2861	198	20	them	they	PRON
admet-2861	198	21	in	in	ADP
admet-2861	198	22	this	this	DET
admet-2861	198	23	capillary	capillary	ADJ
admet-2861	198	24	space	space	NOUN
admet-2861	198	25	,	,	PUNCT
admet-2861	198	26	which	which	PRON
admet-2861	198	27	can	can	AUX
admet-2861	198	28	lead	lead	VERB
admet-2861	198	29	to	to	ADP
admet-2861	198	30	rapid	rapid	ADJ
admet-2861	198	31	saturation	saturation	NOUN
admet-2861	198	32	and	and	CCONJ
admet-2861	198	33	affect	affect	VERB
admet-2861	198	34	the	the	DET
admet-2861	198	35	results	result	NOUN
admet-2861	198	36	.	.	PUNCT
admet-2861	199	1	the	the	DET
admet-2861	199	2	effect	effect	NOUN
admet-2861	199	3	of	of	ADP
admet-2861	199	4	higher	high	ADJ
admet-2861	199	5	concentrations	concentration	NOUN
admet-2861	199	6	was	be	AUX
admet-2861	199	7	examined	examine	VERB
admet-2861	199	8	by	by	ADP
admet-2861	199	9	comparing	compare	VERB
admet-2861	199	10	the	the	DET
admet-2861	199	11	drug	drug	NOUN
admet-2861	199	12	dissolution	dissolution	NOUN
admet-2861	199	13	profiles	profile	NOUN
admet-2861	199	14	obtained	obtain	VERB
admet-2861	199	15	with	with	ADP
admet-2861	199	16	the	the	DET
admet-2861	199	17	standard	standard	ADJ
admet-2861	199	18	sample	sample	NOUN
admet-2861	199	19	,	,	PUNCT
admet-2861	199	20	consisting	consist	VERB
admet-2861	199	21	of	of	ADP
admet-2861	199	22	10	10	NUM
admet-2861	199	23	activations	activation	NOUN
admet-2861	199	24	,	,	PUNCT
admet-2861	199	25	and	and	CCONJ
admet-2861	199	26	the	the	DET
admet-2861	199	27	sample	sample	NOUN
admet-2861	199	28	composed	compose	VERB
admet-2861	199	29	of	of	ADP
admet-2861	199	30	15	15	NUM
admet-2861	199	31	activations	activation	NOUN
admet-2861	199	32	.	.	PUNCT
admet-2861	200	1	the	the	DET
admet-2861	200	2	obtained	obtain	VERB
admet-2861	200	3	profiles	profile	NOUN
admet-2861	200	4	are	be	AUX
admet-2861	200	5	presented	present	VERB
admet-2861	200	6	in	in	ADP
admet-2861	200	7	figure	figure	NOUN
admet-2861	200	8	6	6	NUM
admet-2861	200	9	.	.	PUNCT
admet-2861	201	1	no	no	DET
admet-2861	201	2	significant	significant	ADJ
admet-2861	201	3	difference	difference	NOUN
admet-2861	201	4	in	in	ADP
admet-2861	201	5	bdp	bdp	PROPN
admet-2861	201	6	dissolution	dissolution	PROPN
admet-2861	201	7	rate	rate	NOUN
admet-2861	201	8	was	be	AUX
admet-2861	201	9	observed	observe	VERB
admet-2861	201	10	between	between	ADP
admet-2861	201	11	different	different	ADJ
admet-2861	201	12	sample	sample	NOUN
admet-2861	201	13	sizes	size	NOUN
admet-2861	201	14	(	(	PUNCT
admet-2861	201	15	f1	f1	NOUN
admet-2861	201	16	=	=	SYM
admet-2861	201	17	7.5	7.5	NUM
admet-2861	201	18	,	,	PUNCT
admet-2861	201	19	f2	f2	PROPN
admet-2861	201	20	=	=	NOUN
admet-2861	201	21	78.0	78.0	NUM
admet-2861	201	22	)	)	PUNCT
admet-2861	201	23	.	.	PUNCT
admet-2861	202	1	the	the	DET
admet-2861	202	2	absence	absence	NOUN
admet-2861	202	3	of	of	ADP
admet-2861	202	4	the	the	DET
admet-2861	202	5	influence	influence	NOUN
admet-2861	202	6	of	of	ADP
admet-2861	202	7	sample	sample	NOUN
admet-2861	202	8	size	size	NOUN
admet-2861	202	9	on	on	ADP
admet-2861	202	10	variation	variation	NOUN
admet-2861	202	11	is	be	AUX
admet-2861	202	12	important	important	ADJ
admet-2861	202	13	,	,	PUNCT
admet-2861	202	14	as	as	SCONJ
admet-2861	202	15	it	it	PRON
admet-2861	202	16	allows	allow	VERB
admet-2861	202	17	the	the	DET
admet-2861	202	18	use	use	NOUN
admet-2861	202	19	of	of	ADP
admet-2861	202	20	multiple	multiple	ADJ
admet-2861	202	21	doses	dose	NOUN
admet-2861	202	22	,	,	PUNCT
admet-2861	202	23	meaning	mean	VERB
admet-2861	202	24	that	that	SCONJ
admet-2861	202	25	quantifying	quantify	VERB
admet-2861	202	26	small	small	ADJ
admet-2861	202	27	amounts	amount	NOUN
admet-2861	202	28	of	of	ADP
admet-2861	202	29	active	active	ADJ
admet-2861	202	30	substance	substance	NOUN
admet-2861	202	31	should	should	AUX
admet-2861	202	32	be	be	AUX
admet-2861	202	33	easier	easy	ADJ
admet-2861	202	34	and	and	CCONJ
admet-2861	202	35	can	can	AUX
admet-2861	202	36	be	be	AUX
admet-2861	202	37	carried	carry	VERB
admet-2861	202	38	out	out	ADP
admet-2861	202	39	using	use	VERB
admet-2861	202	40	conventional	conventional	ADJ
admet-2861	202	41	analytical	analytical	ADJ
admet-2861	202	42	methods	method	NOUN
admet-2861	202	43	,	,	PUNCT
admet-2861	202	44	i.e.	i.e.	X
admet-2861	202	45	hplc	hplc	NOUN
admet-2861	202	46	with	with	ADP
admet-2861	202	47	uv	uv	NOUN
admet-2861	202	48	-	-	PUNCT
admet-2861	202	49	pda	pda	NOUN
admet-2861	202	50	detector	detector	NOUN
admet-2861	202	51	.	.	PUNCT
admet-2861	203	1	figure	figure	NOUN
admet-2861	203	2	6	6	NUM
admet-2861	203	3	.	.	PUNCT
admet-2861	204	1	dissolution	dissolution	ADJ
admet-2861	204	2	profiles	profile	NOUN
admet-2861	204	3	of	of	ADP
admet-2861	204	4	beclomethasone	beclomethasone	ADJ
admet-2861	204	5	dipropionate	dipropionate	NOUN
admet-2861	204	6	from	from	ADP
admet-2861	204	7	samples	sample	NOUN
admet-2861	204	8	containing	contain	VERB
admet-2861	204	9	10	10	NUM
admet-2861	204	10	and	and	CCONJ
admet-2861	204	11	15	15	NUM
admet-2861	204	12	doses	dose	NOUN
admet-2861	204	13	of	of	ADP
admet-2861	204	14	product	product	NOUN
admet-2861	204	15	b1	b1	NOUN
admet-2861	204	16	admet	admet	PROPN
admet-2861	204	17	&	&	CCONJ
admet-2861	204	18	dmpk	dmpk	PROPN
admet-2861	204	19	13	13	NUM
admet-2861	204	20	(	(	PUNCT
admet-2861	204	21	)	)	PUNCT
admet-2861	204	22	(	(	PUNCT
admet-2861	204	23	2025	2025	NUM
admet-2861	204	24	)	)	PUNCT
admet-2861	204	25	2861	2861	NUM
admet-2861	204	26	development	development	NOUN
admet-2861	204	27	of	of	ADP
admet-2861	204	28	a	a	DET
admet-2861	204	29	biorelevant	biorelevant	ADJ
admet-2861	204	30	dissolution	dissolution	NOUN
admet-2861	204	31	method	method	NOUN
admet-2861	204	32	for	for	ADP
admet-2861	204	33	inhalation	inhalation	NOUN
admet-2861	204	34	products	product	NOUN
admet-2861	204	35	doi	doi	NOUN
admet-2861	204	36	:	:	PUNCT
admet-2861	204	37	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	204	38	11	11	NUM
admet-2861	204	39	in	in	ADP
admet-2861	204	40	addition	addition	NOUN
admet-2861	204	41	to	to	ADP
admet-2861	204	42	the	the	DET
admet-2861	204	43	investigated	investigate	VERB
admet-2861	204	44	inhalation	inhalation	NOUN
admet-2861	204	45	products	product	NOUN
admet-2861	204	46	,	,	PUNCT
admet-2861	204	47	the	the	DET
admet-2861	204	48	diffusion	diffusion	NOUN
admet-2861	204	49	profiles	profile	NOUN
admet-2861	204	50	of	of	ADP
admet-2861	204	51	the	the	DET
admet-2861	204	52	investigated	investigate	VERB
admet-2861	204	53	active	active	ADJ
admet-2861	204	54	substances	substance	NOUN
admet-2861	204	55	from	from	ADP
admet-2861	204	56	solution	solution	NOUN
admet-2861	204	57	have	have	AUX
admet-2861	204	58	been	be	AUX
admet-2861	204	59	recorded	record	VERB
admet-2861	204	60	(	(	PUNCT
admet-2861	204	61	figure	figure	NOUN
admet-2861	204	62	7	7	NUM
admet-2861	204	63	)	)	PUNCT
admet-2861	204	64	.	.	PUNCT
admet-2861	205	1	a	a	DET
admet-2861	205	2	quantity	quantity	NOUN
admet-2861	205	3	of	of	ADP
admet-2861	205	4	active	active	ADJ
admet-2861	205	5	substance	substance	NOUN
admet-2861	205	6	(	(	PUNCT
admet-2861	205	7	121.56	121.56	NUM
admet-2861	205	8	µg	µg	NOUN
admet-2861	205	9	of	of	ADP
admet-2861	205	10	salmeterol	salmeterol	NOUN
admet-2861	205	11	and	and	CCONJ
admet-2861	205	12	78.06	78.06	NUM
admet-2861	205	13	µg	µg	X
admet-2861	205	14	of	of	ADP
admet-2861	205	15	bdp	bdp	PROPN
admet-2861	205	16	dissolved	dissolve	VERB
admet-2861	205	17	in	in	ADP
admet-2861	205	18	dissolution	dissolution	PROPN
admet-2861	205	19	medium	medium	NOUN
admet-2861	205	20	)	)	PUNCT
admet-2861	205	21	was	be	AUX
admet-2861	205	22	transferred	transfer	VERB
admet-2861	205	23	to	to	ADP
admet-2861	205	24	an	an	DET
admet-2861	205	25	inverted	invert	VERB
admet-2861	205	26	aci	aci	PROPN
admet-2861	205	27	sample	sample	NOUN
admet-2861	205	28	collection	collection	NOUN
admet-2861	205	29	plate	plate	NOUN
admet-2861	205	30	and	and	CCONJ
admet-2861	205	31	carefully	carefully	ADV
admet-2861	205	32	covered	cover	VERB
admet-2861	205	33	with	with	ADP
admet-2861	205	34	a	a	DET
admet-2861	205	35	previously	previously	ADV
admet-2861	205	36	prepared	prepare	VERB
admet-2861	205	37	agar	agar	NOUN
admet-2861	205	38	membrane	membrane	NOUN
admet-2861	205	39	.	.	PUNCT
admet-2861	206	1	the	the	DET
admet-2861	206	2	membrane	membrane	NOUN
admet-2861	206	3	was	be	AUX
admet-2861	206	4	fixed	fix	VERB
admet-2861	206	5	with	with	ADP
admet-2861	206	6	clips	clip	NOUN
admet-2861	206	7	and	and	CCONJ
admet-2861	206	8	immediately	immediately	ADV
admet-2861	206	9	analysed	analyse	VERB
admet-2861	206	10	using	use	VERB
admet-2861	206	11	a	a	DET
admet-2861	206	12	procedure	procedure	NOUN
admet-2861	206	13	identical	identical	ADJ
admet-2861	206	14	to	to	ADP
admet-2861	206	15	the	the	DET
admet-2861	206	16	one	one	NOUN
admet-2861	206	17	developed	develop	VERB
admet-2861	206	18	for	for	ADP
admet-2861	206	19	the	the	DET
admet-2861	206	20	dissolution	dissolution	NOUN
admet-2861	206	21	method	method	NOUN
admet-2861	206	22	of	of	ADP
admet-2861	206	23	inhalation	inhalation	NOUN
admet-2861	206	24	products	product	NOUN
admet-2861	206	25	.	.	PUNCT
admet-2861	207	1	in	in	ADP
admet-2861	207	2	this	this	DET
admet-2861	207	3	manner	manner	NOUN
admet-2861	207	4	,	,	PUNCT
admet-2861	207	5	the	the	DET
admet-2861	207	6	selectivity	selectivity	NOUN
admet-2861	207	7	of	of	ADP
admet-2861	207	8	the	the	DET
admet-2861	207	9	experimental	experimental	ADJ
admet-2861	207	10	setup	setup	NOUN
admet-2861	207	11	was	be	AUX
admet-2861	207	12	tested	test	VERB
admet-2861	207	13	.	.	PUNCT
admet-2861	208	1	with	with	ADP
admet-2861	208	2	this	this	DET
admet-2861	208	3	test	test	NOUN
admet-2861	208	4	,	,	PUNCT
admet-2861	208	5	a	a	DET
admet-2861	208	6	"	"	PUNCT
admet-2861	208	7	baseline	baseline	NOUN
admet-2861	208	8	"	"	PUNCT
admet-2861	208	9	was	be	AUX
admet-2861	208	10	obtained	obtain	VERB
admet-2861	208	11	,	,	PUNCT
admet-2861	208	12	which	which	PRON
admet-2861	208	13	was	be	AUX
admet-2861	208	14	not	not	PART
admet-2861	208	15	affected	affect	VERB
admet-2861	208	16	by	by	ADP
admet-2861	208	17	the	the	DET
admet-2861	208	18	dissolution	dissolution	NOUN
admet-2861	208	19	rate	rate	NOUN
admet-2861	208	20	of	of	ADP
admet-2861	208	21	solid	solid	ADJ
admet-2861	208	22	particles	particle	NOUN
admet-2861	208	23	of	of	ADP
admet-2861	208	24	the	the	DET
admet-2861	208	25	active	active	ADJ
admet-2861	208	26	substance	substance	NOUN
admet-2861	208	27	but	but	CCONJ
admet-2861	208	28	only	only	ADV
admet-2861	208	29	by	by	ADP
admet-2861	208	30	the	the	DET
admet-2861	208	31	diffusion	diffusion	NOUN
admet-2861	208	32	rate	rate	NOUN
admet-2861	208	33	through	through	ADP
admet-2861	208	34	the	the	DET
admet-2861	208	35	membrane	membrane	NOUN
admet-2861	208	36	.	.	PUNCT
admet-2861	209	1	additionally	additionally	ADV
admet-2861	209	2	,	,	PUNCT
admet-2861	209	3	the	the	DET
admet-2861	209	4	time	time	NOUN
admet-2861	209	5	deviation	deviation	NOUN
admet-2861	209	6	from	from	ADP
admet-2861	209	7	the	the	DET
admet-2861	209	8	start	start	NOUN
admet-2861	209	9	of	of	ADP
admet-2861	209	10	the	the	DET
admet-2861	209	11	test	test	NOUN
admet-2861	209	12	indicated	indicate	VERB
admet-2861	209	13	a	a	DET
admet-2861	209	14	proper	proper	ADJ
admet-2861	209	15	technical	technical	ADJ
admet-2861	209	16	setup	setup	NOUN
admet-2861	209	17	of	of	ADP
admet-2861	209	18	the	the	DET
admet-2861	209	19	apparatus	apparatus	NOUN
admet-2861	209	20	.	.	PUNCT
admet-2861	210	1	the	the	DET
admet-2861	210	2	lack	lack	NOUN
admet-2861	210	3	of	of	ADP
admet-2861	210	4	an	an	DET
admet-2861	210	5	immediate	immediate	ADJ
admet-2861	210	6	release	release	NOUN
admet-2861	210	7	of	of	ADP
admet-2861	210	8	the	the	DET
admet-2861	210	9	tested	test	VERB
admet-2861	210	10	substance	substance	NOUN
admet-2861	210	11	and	and	CCONJ
admet-2861	210	12	its	its	PRON
admet-2861	210	13	performance	performance	NOUN
admet-2861	210	14	along	along	ADP
admet-2861	210	15	the	the	DET
admet-2861	210	16	release	release	NOUN
admet-2861	210	17	profile	profile	NOUN
admet-2861	210	18	curve	curve	NOUN
admet-2861	210	19	plateau	plateau	NOUN
admet-2861	210	20	suggested	suggest	VERB
admet-2861	210	21	that	that	SCONJ
admet-2861	210	22	the	the	DET
admet-2861	210	23	apparatus	apparatus	NOUN
admet-2861	210	24	system	system	NOUN
admet-2861	210	25	was	be	AUX
admet-2861	210	26	effectively	effectively	ADV
admet-2861	210	27	sealed	seal	VERB
admet-2861	210	28	.	.	PUNCT
admet-2861	211	1	this	this	PRON
admet-2861	211	2	shows	show	VERB
admet-2861	211	3	that	that	SCONJ
admet-2861	211	4	there	there	PRON
admet-2861	211	5	is	be	VERB
admet-2861	211	6	no	no	DET
admet-2861	211	7	significant	significant	ADJ
admet-2861	211	8	leakage	leakage	NOUN
admet-2861	211	9	of	of	ADP
admet-2861	211	10	the	the	DET
admet-2861	211	11	solution	solution	NOUN
admet-2861	211	12	with	with	ADP
admet-2861	211	13	the	the	DET
admet-2861	211	14	tested	test	VERB
admet-2861	211	15	substance	substance	NOUN
admet-2861	211	16	along	along	ADP
admet-2861	211	17	the	the	DET
admet-2861	211	18	edges	edge	NOUN
admet-2861	211	19	of	of	ADP
admet-2861	211	20	the	the	DET
admet-2861	211	21	metal	metal	NOUN
admet-2861	211	22	plate	plate	NOUN
admet-2861	211	23	and	and	CCONJ
admet-2861	211	24	the	the	DET
admet-2861	211	25	agar	agar	NOUN
admet-2861	211	26	membrane	membrane	NOUN
admet-2861	211	27	,	,	PUNCT
admet-2861	211	28	and	and	CCONJ
admet-2861	211	29	that	that	SCONJ
admet-2861	211	30	the	the	DET
admet-2861	211	31	increase	increase	NOUN
admet-2861	211	32	in	in	ADP
admet-2861	211	33	concentration	concentration	NOUN
admet-2861	211	34	originated	originate	VERB
admet-2861	211	35	from	from	ADP
admet-2861	211	36	the	the	DET
admet-2861	211	37	substance	substance	NOUN
admet-2861	211	38	that	that	PRON
admet-2861	211	39	diffused	diffuse	VERB
admet-2861	211	40	through	through	ADP
admet-2861	211	41	the	the	DET
admet-2861	211	42	agar	agar	NOUN
admet-2861	211	43	membrane	membrane	NOUN
admet-2861	211	44	.	.	PUNCT
admet-2861	212	1	figure	figure	NOUN
admet-2861	212	2	7	7	NUM
admet-2861	212	3	shows	show	VERB
admet-2861	212	4	the	the	DET
admet-2861	212	5	diffusion	diffusion	NOUN
admet-2861	212	6	profiles	profile	NOUN
admet-2861	212	7	obtained	obtain	VERB
admet-2861	212	8	by	by	ADP
admet-2861	212	9	testing	test	VERB
admet-2861	212	10	solutions	solution	NOUN
admet-2861	212	11	of	of	ADP
admet-2861	212	12	sx	sx	PROPN
admet-2861	212	13	and	and	CCONJ
admet-2861	212	14	bdp	bdp	PROPN
admet-2861	212	15	under	under	ADP
admet-2861	212	16	the	the	DET
admet-2861	212	17	designed	design	VERB
admet-2861	212	18	dissolution	dissolution	NOUN
admet-2861	212	19	test	test	NOUN
admet-2861	212	20	setup	setup	NOUN
admet-2861	212	21	.	.	PUNCT
admet-2861	213	1	figure	figure	NOUN
admet-2861	213	2	7	7	NUM
admet-2861	213	3	.	.	PUNCT
admet-2861	213	4	diffusion	diffusion	NOUN
admet-2861	213	5	profiles	profile	NOUN
admet-2861	213	6	of	of	ADP
admet-2861	213	7	sx	sx	PROPN
admet-2861	213	8	and	and	CCONJ
admet-2861	213	9	bdp	bdp	PROPN
admet-2861	213	10	from	from	ADP
admet-2861	213	11	drug	drug	NOUN
admet-2861	213	12	solutions	solution	NOUN
admet-2861	213	13	there	there	PRON
admet-2861	213	14	was	be	VERB
admet-2861	213	15	a	a	DET
admet-2861	213	16	noticeable	noticeable	ADJ
admet-2861	213	17	difference	difference	NOUN
admet-2861	213	18	in	in	ADP
admet-2861	213	19	the	the	DET
admet-2861	213	20	amounts	amount	NOUN
admet-2861	213	21	of	of	ADP
admet-2861	213	22	the	the	DET
admet-2861	213	23	tested	test	VERB
admet-2861	213	24	substances	substance	NOUN
admet-2861	213	25	detected	detect	VERB
admet-2861	213	26	in	in	ADP
admet-2861	213	27	the	the	DET
admet-2861	213	28	medium	medium	NOUN
admet-2861	213	29	at	at	ADP
admet-2861	213	30	the	the	DET
admet-2861	213	31	end	end	NOUN
admet-2861	213	32	of	of	ADP
admet-2861	213	33	the	the	DET
admet-2861	213	34	test	test	NOUN
admet-2861	213	35	.	.	PUNCT
admet-2861	214	1	the	the	DET
admet-2861	214	2	proportion	proportion	NOUN
admet-2861	214	3	of	of	ADP
admet-2861	214	4	sx	sx	NOUN
admet-2861	214	5	diffusing	diffuse	VERB
admet-2861	214	6	through	through	ADP
admet-2861	214	7	the	the	DET
admet-2861	214	8	membrane	membrane	NOUN
admet-2861	214	9	was	be	AUX
admet-2861	214	10	15	15	NUM
admet-2861	214	11	%	%	NOUN
admet-2861	214	12	lower	low	ADJ
admet-2861	214	13	than	than	ADP
admet-2861	214	14	that	that	PRON
admet-2861	214	15	of	of	ADP
admet-2861	214	16	bdp	bdp	PROPN
admet-2861	214	17	.	.	PUNCT
admet-2861	215	1	this	this	PRON
admet-2861	215	2	may	may	AUX
admet-2861	215	3	be	be	AUX
admet-2861	215	4	due	due	ADJ
admet-2861	215	5	to	to	ADP
admet-2861	215	6	the	the	DET
admet-2861	215	7	binding	bind	VERB
admet-2861	215	8	process	process	NOUN
admet-2861	215	9	of	of	ADP
admet-2861	215	10	salmeterol	salmeterol	NOUN
admet-2861	215	11	to	to	ADP
admet-2861	215	12	the	the	DET
admet-2861	215	13	membrane	membrane	NOUN
admet-2861	215	14	.	.	PUNCT
admet-2861	216	1	agar	agar	NOUN
admet-2861	216	2	is	be	AUX
admet-2861	216	3	a	a	DET
admet-2861	216	4	mixture	mixture	NOUN
admet-2861	216	5	of	of	ADP
admet-2861	216	6	two	two	NUM
admet-2861	216	7	polysaccharides	polysaccharide	NOUN
admet-2861	216	8	:	:	PUNCT
admet-2861	216	9	agaropectin	agaropectin	PROPN
admet-2861	216	10	and	and	CCONJ
admet-2861	216	11	agarose	agarose	NOUN
admet-2861	216	12	.	.	PUNCT
admet-2861	217	1	agaropectin	agaropectin	PROPN
admet-2861	217	2	is	be	AUX
admet-2861	217	3	composed	compose	VERB
admet-2861	217	4	of	of	ADP
admet-2861	217	5	d	d	NOUN
admet-2861	217	6	-	-	PUNCT
admet-2861	217	7	galactose	galactose	ADJ
admet-2861	217	8	,	,	PUNCT
admet-2861	217	9	3,6	3,6	NUM
admet-2861	217	10	-	-	PUNCT
admet-2861	217	11	anhydro	anhydro	NOUN
admet-2861	217	12	galactose	galactose	NOUN
admet-2861	217	13	,	,	PUNCT
admet-2861	217	14	d	d	ADJ
admet-2861	217	15	-	-	ADJ
admet-2861	217	16	glucuronic	glucuronic	ADJ
admet-2861	217	17	acid	acid	NOUN
admet-2861	217	18	,	,	PUNCT
admet-2861	217	19	pyruvic	pyruvic	ADJ
admet-2861	217	20	acid	acid	NOUN
admet-2861	217	21	,	,	PUNCT
admet-2861	217	22	and	and	CCONJ
admet-2861	217	23	multiple	multiple	ADJ
admet-2861	217	24	ester	ester	NOUN
admet-2861	217	25	-	-	PUNCT
admet-2861	217	26	linked	link	VERB
admet-2861	217	27	sulphate	sulphate	NOUN
admet-2861	217	28	groups	group	NOUN
admet-2861	217	29	[	[	X
admet-2861	217	30	45	45	NUM
admet-2861	217	31	]	]	PUNCT
admet-2861	217	32	.	.	PUNCT
admet-2861	218	1	these	these	DET
admet-2861	218	2	acidic	acidic	ADJ
admet-2861	218	3	residues	residue	NOUN
admet-2861	218	4	form	form	VERB
admet-2861	218	5	potential	potential	ADJ
admet-2861	218	6	binding	bind	VERB
admet-2861	218	7	sites	site	NOUN
admet-2861	218	8	for	for	ADP
admet-2861	218	9	salmeterol	salmeterol	NOUN
admet-2861	218	10	base	base	NOUN
admet-2861	218	11	,	,	PUNCT
admet-2861	218	12	which	which	PRON
admet-2861	218	13	could	could	AUX
admet-2861	218	14	explain	explain	VERB
admet-2861	218	15	the	the	DET
admet-2861	218	16	obtained	obtain	VERB
admet-2861	218	17	results	result	NOUN
admet-2861	218	18	.	.	PUNCT
admet-2861	219	1	the	the	DET
admet-2861	219	2	dissolution	dissolution	ADJ
admet-2861	219	3	profiles	profile	NOUN
admet-2861	219	4	of	of	ADP
admet-2861	219	5	the	the	DET
admet-2861	219	6	sx	sx	PROPN
admet-2861	219	7	formulations	formulation	NOUN
admet-2861	219	8	are	be	AUX
admet-2861	219	9	presented	present	VERB
admet-2861	219	10	in	in	ADP
admet-2861	219	11	figure	figure	NOUN
admet-2861	219	12	8	8	NUM
admet-2861	219	13	.	.	PUNCT
admet-2861	220	1	the	the	DET
admet-2861	220	2	shape	shape	NOUN
admet-2861	220	3	and	and	CCONJ
admet-2861	220	4	uniformity	uniformity	NOUN
admet-2861	220	5	of	of	ADP
admet-2861	220	6	the	the	DET
admet-2861	220	7	obtained	obtain	VERB
admet-2861	220	8	profiles	profile	NOUN
admet-2861	220	9	indicate	indicate	VERB
admet-2861	220	10	a	a	DET
admet-2861	220	11	relatively	relatively	ADV
admet-2861	220	12	rapid	rapid	ADJ
admet-2861	220	13	dissolution	dissolution	NOUN
admet-2861	220	14	of	of	ADP
admet-2861	220	15	the	the	DET
admet-2861	220	16	active	active	ADJ
admet-2861	220	17	substance	substance	NOUN
admet-2861	220	18	,	,	PUNCT
admet-2861	220	19	confirming	confirm	VERB
admet-2861	220	20	the	the	DET
admet-2861	220	21	assumption	assumption	NOUN
admet-2861	220	22	that	that	SCONJ
admet-2861	220	23	dissolution	dissolution	NOUN
admet-2861	220	24	was	be	AUX
admet-2861	220	25	not	not	PART
admet-2861	220	26	a	a	DET
admet-2861	220	27	limiting	limit	VERB
admet-2861	220	28	factor	factor	NOUN
admet-2861	220	29	for	for	ADP
admet-2861	220	30	sx	sx	PROPN
admet-2861	220	31	release	release	NOUN
admet-2861	220	32	.	.	PUNCT
admet-2861	221	1	comparison	comparison	NOUN
admet-2861	221	2	of	of	ADP
admet-2861	221	3	the	the	DET
admet-2861	221	4	dissolution	dissolution	NOUN
admet-2861	221	5	profiles	profile	NOUN
admet-2861	221	6	using	use	VERB
admet-2861	221	7	model	model	NOUN
admet-2861	221	8	-	-	PUNCT
admet-2861	221	9	independent	independent	ADJ
admet-2861	221	10	methods	method	NOUN
admet-2861	221	11	detected	detect	VERB
admet-2861	221	12	significant	significant	ADJ
admet-2861	221	13	differences	difference	NOUN
admet-2861	221	14	between	between	ADP
admet-2861	221	15	products	product	NOUN
admet-2861	221	16	s2	s2	NOUN
admet-2861	221	17	and	and	CCONJ
admet-2861	221	18	s4	s4	VERB
admet-2861	221	19	with	with	ADP
admet-2861	221	20	the	the	DET
admet-2861	221	21	reference	reference	NOUN
admet-2861	221	22	solution	solution	NOUN
admet-2861	221	23	sx	sx	PROPN
admet-2861	221	24	(	(	PUNCT
admet-2861	221	25	table	table	NOUN
admet-2861	221	26	4	4	NUM
admet-2861	221	27	)	)	PUNCT
admet-2861	221	28	.	.	PUNCT
admet-2861	222	1	these	these	DET
admet-2861	222	2	differences	difference	NOUN
admet-2861	222	3	were	be	AUX
admet-2861	222	4	not	not	PART
admet-2861	222	5	detected	detect	VERB
admet-2861	222	6	for	for	ADP
admet-2861	222	7	the	the	DET
admet-2861	222	8	products	product	NOUN
admet-2861	222	9	s1	s1	NOUN
admet-2861	222	10	and	and	CCONJ
admet-2861	222	11	s3	s3	PROPN
admet-2861	222	12	.	.	PUNCT
admet-2861	223	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	223	2	a.	a.	PROPN
admet-2861	223	3	elezović	elezović	PROPN
admet-2861	223	4	et	et	PROPN
admet-2861	223	5	al	al	PROPN
admet-2861	223	6	.	.	PROPN
admet-2861	223	7	admet	admet	PROPN
admet-2861	223	8	&	&	CCONJ
admet-2861	223	9	dmpk	dmpk	PROPN
admet-2861	223	10	13(5	13(5	NUM
admet-2861	223	11	)	)	PUNCT
admet-2861	223	12	(	(	PUNCT
admet-2861	223	13	2025	2025	NUM
admet-2861	223	14	)	)	PUNCT
admet-2861	223	15	2861	2861	NUM
admet-2861	223	16	12	12	NUM
admet-2861	223	17	figure	figure	NOUN
admet-2861	223	18	8	8	NUM
admet-2861	223	19	.	.	PUNCT
admet-2861	224	1	dissolution	dissolution	ADJ
admet-2861	224	2	profiles	profile	NOUN
admet-2861	224	3	of	of	ADP
admet-2861	224	4	sx	sx	NOUN
admet-2861	224	5	samples	sample	NOUN
admet-2861	224	6	(	(	PUNCT
admet-2861	224	7	n	n	NOUN
admet-2861	224	8	=	=	SYM
admet-2861	224	9	3	3	NUM
admet-2861	224	10	,	,	PUNCT
admet-2861	224	11	mean	mean	VERB
admet-2861	224	12	±	±	NUM
admet-2861	224	13	sd	sd	NOUN
admet-2861	224	14	)	)	PUNCT
admet-2861	224	15	apart	apart	ADV
admet-2861	224	16	from	from	ADP
admet-2861	224	17	the	the	DET
admet-2861	224	18	carrier	carrier	NOUN
admet-2861	224	19	gas	gas	NOUN
admet-2861	224	20	,	,	PUNCT
admet-2861	224	21	products	product	NOUN
admet-2861	224	22	s1	s1	NOUN
admet-2861	224	23	,	,	PUNCT
admet-2861	224	24	s2	s2	NOUN
admet-2861	224	25	,	,	PUNCT
admet-2861	224	26	and	and	CCONJ
admet-2861	224	27	s3	s3	PROPN
admet-2861	224	28	do	do	AUX
admet-2861	224	29	not	not	PART
admet-2861	224	30	contain	contain	VERB
admet-2861	224	31	any	any	DET
admet-2861	224	32	additional	additional	ADJ
admet-2861	224	33	excipients	excipient	NOUN
admet-2861	224	34	.	.	PUNCT
admet-2861	225	1	product	product	NOUN
admet-2861	225	2	s4	s4	PROPN
admet-2861	225	3	additionally	additionally	ADV
admet-2861	225	4	contains	contain	VERB
admet-2861	225	5	ethanol	ethanol	NOUN
admet-2861	225	6	(	(	PUNCT
admet-2861	225	7	as	as	ADP
admet-2861	225	8	a	a	DET
admet-2861	225	9	cosolvent	cosolvent	NOUN
admet-2861	225	10	[	[	X
admet-2861	225	11	46	46	NUM
admet-2861	225	12	]	]	PUNCT
admet-2861	225	13	)	)	PUNCT
admet-2861	225	14	and	and	CCONJ
admet-2861	225	15	soy	soy	NOUN
admet-2861	225	16	lecithin	lecithin	NOUN
admet-2861	225	17	(	(	PUNCT
admet-2861	225	18	a	a	DET
admet-2861	225	19	surfactant	surfactant	NOUN
admet-2861	225	20	that	that	PRON
admet-2861	225	21	prevents	prevent	VERB
admet-2861	225	22	particle	particle	NOUN
admet-2861	225	23	agglomeration	agglomeration	NOUN
admet-2861	225	24	[	[	X
admet-2861	225	25	47	47	NUM
admet-2861	225	26	]	]	PUNCT
admet-2861	225	27	)	)	PUNCT
admet-2861	225	28	.	.	PUNCT
admet-2861	226	1	table	table	NOUN
admet-2861	226	2	4	4	NUM
admet-2861	226	3	.	.	PUNCT
admet-2861	226	4	comparison	comparison	NOUN
admet-2861	226	5	of	of	ADP
admet-2861	226	6	sx	sx	PROPN
admet-2861	226	7	dissolution	dissolution	PROPN
admet-2861	226	8	profiles	profile	NOUN
admet-2861	226	9	from	from	ADP
admet-2861	226	10	the	the	DET
admet-2861	226	11	tested	test	VERB
admet-2861	226	12	products	product	NOUN
admet-2861	226	13	and	and	CCONJ
admet-2861	226	14	the	the	DET
admet-2861	226	15	reference	reference	NOUN
admet-2861	226	16	solution	solution	NOUN
admet-2861	226	17	sx	sx	PROPN
admet-2861	226	18	using	use	VERB
admet-2861	226	19	modelindependent	modelindependent	NOUN
admet-2861	226	20	methods	method	NOUN
admet-2861	226	21	compared	compare	VERB
admet-2861	226	22	dissolution	dissolution	ADJ
admet-2861	226	23	curves	curve	NOUN
admet-2861	226	24	f1	f1	NOUN
admet-2861	226	25	f2	f2	PROPN
admet-2861	226	26	s1	s1	NOUN
admet-2861	226	27	/	/	SYM
admet-2861	226	28	solution	solution	NOUN
admet-2861	226	29	sx	sx	PROPN
admet-2861	226	30	13.8	13.8	NUM
admet-2861	226	31	52.9	52.9	NUM
admet-2861	226	32	s2	s2	NOUN
admet-2861	226	33	/	/	SYM
admet-2861	226	34	solution	solution	NOUN
admet-2861	226	35	sx	sx	PROPN
admet-2861	226	36	25.1	25.1	NUM
admet-2861	226	37	41.8	41.8	NUM
admet-2861	226	38	s3	s3	PROPN
admet-2861	226	39	/	/	SYM
admet-2861	226	40	solution	solution	NOUN
admet-2861	226	41	sx	sx	PROPN
admet-2861	226	42	13.3	13.3	NUM
admet-2861	226	43	51.9	51.9	NUM
admet-2861	226	44	s4	s4	NOUN
admet-2861	226	45	/	/	SYM
admet-2861	226	46	solution	solution	NOUN
admet-2861	226	47	sx	sx	PROPN
admet-2861	226	48	21.1	21.1	NUM
admet-2861	226	49	42.1	42.1	NUM
admet-2861	226	50	a	a	DET
admet-2861	226	51	comparison	comparison	NOUN
admet-2861	226	52	of	of	ADP
admet-2861	226	53	the	the	DET
admet-2861	226	54	dissolution	dissolution	ADJ
admet-2861	226	55	profiles	profile	NOUN
admet-2861	226	56	of	of	ADP
admet-2861	226	57	the	the	DET
admet-2861	226	58	investigated	investigate	VERB
admet-2861	226	59	products	product	NOUN
admet-2861	226	60	using	use	VERB
admet-2861	226	61	model	model	NOUN
admet-2861	226	62	-	-	PUNCT
admet-2861	226	63	independent	independent	ADJ
admet-2861	226	64	methods	method	NOUN
admet-2861	226	65	did	do	AUX
admet-2861	226	66	not	not	PART
admet-2861	226	67	reveal	reveal	VERB
admet-2861	226	68	any	any	DET
admet-2861	226	69	differences	difference	NOUN
admet-2861	226	70	in	in	ADP
admet-2861	226	71	the	the	DET
admet-2861	226	72	dissolution	dissolution	ADJ
admet-2861	226	73	profiles	profile	NOUN
admet-2861	226	74	of	of	ADP
admet-2861	226	75	the	the	DET
admet-2861	226	76	tested	test	VERB
admet-2861	226	77	preparations	preparation	NOUN
admet-2861	226	78	,	,	PUNCT
admet-2861	226	79	as	as	SCONJ
admet-2861	226	80	shown	show	VERB
admet-2861	226	81	in	in	ADP
admet-2861	226	82	table	table	NOUN
admet-2861	226	83	5	5	NUM
admet-2861	226	84	.	.	PUNCT
admet-2861	226	85	table	table	NOUN
admet-2861	226	86	5	5	NUM
admet-2861	226	87	.	.	PUNCT
admet-2861	226	88	comparison	comparison	NOUN
admet-2861	226	89	of	of	ADP
admet-2861	226	90	sx	sx	PROPN
admet-2861	226	91	dissolution	dissolution	PROPN
admet-2861	226	92	profiles	profile	NOUN
admet-2861	226	93	from	from	ADP
admet-2861	226	94	tested	test	VERB
admet-2861	226	95	products	product	NOUN
admet-2861	226	96	using	use	VERB
admet-2861	226	97	model	model	NOUN
admet-2861	226	98	-	-	PUNCT
admet-2861	226	99	independent	independent	ADJ
admet-2861	226	100	methods	method	NOUN
admet-2861	226	101	compared	compare	VERB
admet-2861	226	102	dissolution	dissolution	NOUN
admet-2861	226	103	profiles	profile	NOUN
admet-2861	226	104	f1	f1	VERB
admet-2861	226	105	f2	f2	PROPN
admet-2861	226	106	s1	s1	PROPN
admet-2861	226	107	/	/	SYM
admet-2861	226	108	s2	s2	NOUN
admet-2861	226	109	11.3	11.3	NUM
admet-2861	226	110	57.5	57.5	NUM
admet-2861	226	111	s2	s2	PROPN
admet-2861	226	112	/	/	SYM
admet-2861	226	113	s1	s1	PROPN
admet-2861	226	114	10.2	10.2	NUM
admet-2861	226	115	s2	s2	PROPN
admet-2861	226	116	/	/	SYM
admet-2861	226	117	s3	s3	PROPN
admet-2861	226	118	11.8	11.8	NUM
admet-2861	226	119	56.2	56.2	NUM
admet-2861	226	120	s3	s3	PROPN
admet-2861	226	121	/	/	SYM
admet-2861	226	122	s2	s2	NOUN
admet-2861	226	123	13.4	13.4	NUM
admet-2861	226	124	s1	s1	NOUN
admet-2861	226	125	/	/	SYM
admet-2861	226	126	s3	s3	PROPN
admet-2861	226	127	3.5	3.5	NUM
admet-2861	226	128	79.8	79.8	NUM
admet-2861	226	129	s3	s3	PROPN
admet-2861	226	130	/	/	SYM
admet-2861	226	131	s1	s1	PROPN
admet-2861	226	132	3.6	3.6	NUM
admet-2861	226	133	s1	s1	NOUN
admet-2861	226	134	/	/	SYM
admet-2861	226	135	s4	s4	PROPN
admet-2861	226	136	9.3	9.3	NUM
admet-2861	226	137	62.2	62.2	NUM
admet-2861	226	138	s4	s4	PROPN
admet-2861	226	139	/	/	SYM
admet-2861	226	140	s1	s1	PROPN
admet-2861	226	141	8.8	8.8	NUM
admet-2861	226	142	s2	s2	PROPN
admet-2861	226	143	/	/	SYM
admet-2861	226	144	s4	s4	PROPN
admet-2861	226	145	5.6	5.6	NUM
admet-2861	226	146	73.2	73.2	NUM
admet-2861	226	147	s4	s4	PROPN
admet-2861	226	148	/	/	SYM
admet-2861	226	149	s2	s2	PROPN
admet-2861	226	150	5.9	5.9	NUM
admet-2861	226	151	s3	s3	PROPN
admet-2861	226	152	/	/	SYM
admet-2861	226	153	s4	s4	PROPN
admet-2861	226	154	8.1	8.1	NUM
admet-2861	226	155	64.0	64.0	NUM
admet-2861	226	156	s4	s4	PROPN
admet-2861	226	157	/	/	SYM
admet-2861	226	158	s3	s3	PROPN
admet-2861	226	159	7.6	7.6	NUM
admet-2861	226	160	the	the	DET
admet-2861	226	161	presence	presence	NOUN
admet-2861	226	162	of	of	ADP
admet-2861	226	163	lecithin	lecithin	NOUN
admet-2861	226	164	may	may	AUX
admet-2861	226	165	explain	explain	VERB
admet-2861	226	166	the	the	DET
admet-2861	226	167	slight	slight	ADJ
admet-2861	226	168	increase	increase	NOUN
admet-2861	226	169	in	in	ADP
admet-2861	226	170	the	the	DET
admet-2861	226	171	release	release	NOUN
admet-2861	226	172	rate	rate	NOUN
admet-2861	226	173	of	of	ADP
admet-2861	226	174	product	product	NOUN
admet-2861	226	175	s4	s4	NOUN
admet-2861	226	176	compared	compare	VERB
admet-2861	226	177	to	to	ADP
admet-2861	226	178	product	product	NOUN
admet-2861	226	179	s2	s2	NOUN
admet-2861	226	180	;	;	PUNCT
admet-2861	226	181	however	however	ADV
admet-2861	226	182	,	,	PUNCT
admet-2861	226	183	it	it	PRON
admet-2861	226	184	does	do	AUX
admet-2861	226	185	not	not	PART
admet-2861	226	186	account	account	VERB
admet-2861	226	187	for	for	ADP
admet-2861	226	188	the	the	DET
admet-2861	226	189	faster	fast	ADJ
admet-2861	226	190	release	release	NOUN
admet-2861	226	191	of	of	ADP
admet-2861	226	192	products	product	NOUN
admet-2861	226	193	s1	s1	NOUN
admet-2861	226	194	and	and	CCONJ
admet-2861	226	195	s3	s3	PROPN
admet-2861	226	196	,	,	PUNCT
admet-2861	226	197	which	which	PRON
admet-2861	226	198	do	do	AUX
admet-2861	226	199	not	not	PART
admet-2861	226	200	contain	contain	VERB
admet-2861	226	201	additional	additional	ADJ
admet-2861	226	202	excipients	excipient	NOUN
admet-2861	226	203	except	except	SCONJ
admet-2861	226	204	for	for	ADP
admet-2861	226	205	the	the	DET
admet-2861	226	206	carrier	carrier	NOUN
admet-2861	226	207	gas	gas	NOUN
admet-2861	226	208	and	and	CCONJ
admet-2861	226	209	include	include	VERB
admet-2861	226	210	an	an	DET
admet-2861	226	211	additional	additional	ADJ
admet-2861	226	212	poorly	poorly	ADV
admet-2861	226	213	soluble	soluble	ADJ
admet-2861	226	214	active	active	ADJ
admet-2861	226	215	substance	substance	NOUN
admet-2861	226	216	fluticasone	fluticasone	NOUN
admet-2861	226	217	propionate	propionate	NOUN
admet-2861	226	218	.	.	PUNCT
admet-2861	227	1	the	the	DET
admet-2861	227	2	obtained	obtain	VERB
admet-2861	227	3	dissolution	dissolution	NOUN
admet-2861	227	4	curves	curve	NOUN
admet-2861	227	5	of	of	ADP
admet-2861	227	6	products	product	NOUN
admet-2861	227	7	s1	s1	NOUN
admet-2861	227	8	and	and	CCONJ
admet-2861	227	9	s3	s3	PROPN
admet-2861	227	10	do	do	AUX
admet-2861	227	11	not	not	PART
admet-2861	227	12	show	show	VERB
admet-2861	227	13	significant	significant	ADJ
admet-2861	227	14	differences	difference	NOUN
admet-2861	227	15	compared	compare	VERB
admet-2861	227	16	to	to	ADP
admet-2861	227	17	the	the	DET
admet-2861	227	18	release	release	NOUN
admet-2861	227	19	of	of	ADP
admet-2861	227	20	the	the	DET
admet-2861	227	21	reference	reference	NOUN
admet-2861	227	22	solution	solution	NOUN
admet-2861	227	23	sx	sx	PROPN
admet-2861	227	24	.	.	PUNCT
admet-2861	228	1	the	the	DET
admet-2861	228	2	presence	presence	NOUN
admet-2861	228	3	of	of	ADP
admet-2861	228	4	fluticasone	fluticasone	NOUN
admet-2861	228	5	propionate	propionate	NOUN
admet-2861	228	6	can	can	AUX
admet-2861	228	7	lead	lead	VERB
admet-2861	228	8	to	to	ADP
admet-2861	228	9	the	the	DET
admet-2861	228	10	formation	formation	NOUN
admet-2861	228	11	of	of	ADP
admet-2861	228	12	“	"	PUNCT
admet-2861	228	13	combined	combined	ADJ
admet-2861	228	14	particles	particle	NOUN
admet-2861	228	15	”	"	PUNCT
admet-2861	228	16	containing	contain	VERB
admet-2861	228	17	both	both	CCONJ
admet-2861	228	18	active	active	ADJ
admet-2861	228	19	substances	substance	NOUN
admet-2861	228	20	sx	sx	PROPN
admet-2861	228	21	and	and	CCONJ
admet-2861	228	22	fluticasone	fluticasone	PROPN
admet-2861	228	23	admet	admet	PROPN
admet-2861	228	24	&	&	CCONJ
admet-2861	228	25	dmpk	dmpk	PROPN
admet-2861	228	26	13	13	NUM
admet-2861	228	27	(	(	PUNCT
admet-2861	228	28	)	)	PUNCT
admet-2861	228	29	(	(	PUNCT
admet-2861	228	30	2025	2025	NUM
admet-2861	228	31	)	)	PUNCT
admet-2861	228	32	2861	2861	NUM
admet-2861	228	33	development	development	NOUN
admet-2861	228	34	of	of	ADP
admet-2861	228	35	a	a	DET
admet-2861	228	36	biorelevant	biorelevant	ADJ
admet-2861	228	37	dissolution	dissolution	NOUN
admet-2861	228	38	method	method	NOUN
admet-2861	228	39	for	for	ADP
admet-2861	228	40	inhalation	inhalation	NOUN
admet-2861	228	41	products	product	NOUN
admet-2861	228	42	doi	doi	NOUN
admet-2861	228	43	:	:	PUNCT
admet-2861	228	44	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	228	45	13	13	NUM
admet-2861	228	46	propionate	propionate	NOUN
admet-2861	228	47	.	.	PUNCT
admet-2861	229	1	such	such	DET
admet-2861	229	2	a	a	DET
admet-2861	229	3	phenomenon	phenomenon	NOUN
admet-2861	229	4	was	be	AUX
admet-2861	229	5	described	describe	VERB
admet-2861	229	6	by	by	ADP
admet-2861	229	7	theophilus	theophilus	PROPN
admet-2861	229	8	et	et	PROPN
admet-2861	229	9	al	al	PROPN
admet-2861	229	10	.	.	PUNCT
admet-2861	230	1	[	[	X
admet-2861	230	2	48	48	NUM
admet-2861	230	3	]	]	PUNCT
admet-2861	230	4	,	,	PUNCT
admet-2861	230	5	who	who	PRON
admet-2861	230	6	examined	examine	VERB
admet-2861	230	7	the	the	DET
admet-2861	230	8	degree	degree	NOUN
admet-2861	230	9	of	of	ADP
admet-2861	230	10	coassociation	coassociation	NOUN
admet-2861	230	11	of	of	ADP
admet-2861	230	12	salmeterol	salmeterol	PROPN
admet-2861	230	13	and	and	CCONJ
admet-2861	230	14	fluticasone	fluticasone	NOUN
admet-2861	230	15	propionate	propionate	NOUN
admet-2861	230	16	particles	particle	NOUN
admet-2861	230	17	in	in	ADP
admet-2861	230	18	combined	combine	VERB
admet-2861	230	19	mdi	mdi	PROPN
admet-2861	230	20	products	product	NOUN
admet-2861	230	21	compared	compare	VERB
admet-2861	230	22	to	to	ADP
admet-2861	230	23	individual	individual	ADJ
admet-2861	230	24	preparations	preparation	NOUN
admet-2861	230	25	.	.	PUNCT
admet-2861	231	1	the	the	DET
admet-2861	231	2	creation	creation	NOUN
admet-2861	231	3	of	of	ADP
admet-2861	231	4	combined	combined	ADJ
admet-2861	231	5	particles	particle	NOUN
admet-2861	231	6	could	could	AUX
admet-2861	231	7	lead	lead	VERB
admet-2861	231	8	to	to	ADP
admet-2861	231	9	an	an	DET
admet-2861	231	10	increase	increase	NOUN
admet-2861	231	11	in	in	ADP
admet-2861	231	12	particle	particle	NOUN
admet-2861	231	13	size	size	NOUN
admet-2861	231	14	,	,	PUNCT
admet-2861	231	15	as	as	SCONJ
admet-2861	231	16	detected	detect	VERB
admet-2861	231	17	in	in	ADP
admet-2861	231	18	the	the	DET
admet-2861	231	19	tested	test	VERB
admet-2861	231	20	samples	sample	NOUN
admet-2861	231	21	.	.	PUNCT
admet-2861	232	1	the	the	DET
admet-2861	232	2	median	median	ADJ
admet-2861	232	3	particle	particle	NOUN
admet-2861	232	4	size	size	NOUN
admet-2861	232	5	(	(	PUNCT
admet-2861	232	6	mmad	mmad	NOUN
admet-2861	232	7	)	)	PUNCT
admet-2861	232	8	values	value	NOUN
admet-2861	232	9	of	of	ADP
admet-2861	232	10	sx	sx	PROPN
admet-2861	232	11	in	in	ADP
admet-2861	232	12	products	product	NOUN
admet-2861	232	13	s1	s1	NOUN
admet-2861	232	14	and	and	CCONJ
admet-2861	232	15	s3	s3	PROPN
admet-2861	232	16	,	,	PUNCT
admet-2861	232	17	which	which	PRON
admet-2861	232	18	were	be	AUX
admet-2861	232	19	combined	combined	ADJ
admet-2861	232	20	preparations	preparation	NOUN
admet-2861	232	21	,	,	PUNCT
admet-2861	232	22	were	be	AUX
admet-2861	232	23	almost	almost	ADV
admet-2861	232	24	twice	twice	ADV
admet-2861	232	25	as	as	ADV
admet-2861	232	26	large	large	ADJ
admet-2861	232	27	as	as	ADP
admet-2861	232	28	in	in	ADP
admet-2861	232	29	products	product	NOUN
admet-2861	232	30	s2	s2	NOUN
admet-2861	232	31	and	and	CCONJ
admet-2861	232	32	s4	s4	PROPN
admet-2861	232	33	containing	contain	VERB
admet-2861	232	34	only	only	ADV
admet-2861	232	35	sx	sx	PROPN
admet-2861	232	36	(	(	PUNCT
admet-2861	232	37	table	table	NOUN
admet-2861	232	38	1	1	NUM
admet-2861	232	39	)	)	PUNCT
admet-2861	232	40	.	.	PUNCT
admet-2861	233	1	the	the	DET
admet-2861	233	2	creation	creation	NOUN
admet-2861	233	3	of	of	ADP
admet-2861	233	4	combined	combined	ADJ
admet-2861	233	5	particles	particle	NOUN
admet-2861	233	6	could	could	AUX
admet-2861	233	7	also	also	ADV
admet-2861	233	8	lead	lead	VERB
admet-2861	233	9	to	to	ADP
admet-2861	233	10	the	the	DET
admet-2861	233	11	formation	formation	NOUN
admet-2861	233	12	of	of	ADP
admet-2861	233	13	hydrophobic	hydrophobic	NOUN
admet-2861	233	14	parts	part	NOUN
admet-2861	233	15	due	due	ADP
admet-2861	233	16	to	to	ADP
admet-2861	233	17	the	the	DET
admet-2861	233	18	presence	presence	NOUN
admet-2861	233	19	of	of	ADP
admet-2861	233	20	fluticasone	fluticasone	NOUN
admet-2861	233	21	propionate	propionate	NOUN
admet-2861	233	22	,	,	PUNCT
admet-2861	233	23	and	and	CCONJ
admet-2861	233	24	together	together	ADV
admet-2861	233	25	,	,	PUNCT
admet-2861	233	26	this	this	PRON
admet-2861	233	27	could	could	AUX
admet-2861	233	28	result	result	VERB
admet-2861	233	29	in	in	ADP
admet-2861	233	30	a	a	DET
admet-2861	233	31	decrease	decrease	NOUN
admet-2861	233	32	in	in	ADP
admet-2861	233	33	the	the	DET
admet-2861	233	34	release	release	NOUN
admet-2861	233	35	rate	rate	NOUN
admet-2861	233	36	,	,	PUNCT
admet-2861	233	37	which	which	PRON
admet-2861	233	38	is	be	AUX
admet-2861	233	39	contrary	contrary	ADJ
admet-2861	233	40	to	to	ADP
admet-2861	233	41	the	the	DET
admet-2861	233	42	obtained	obtain	VERB
admet-2861	233	43	results	result	NOUN
admet-2861	233	44	.	.	PUNCT
admet-2861	234	1	the	the	DET
admet-2861	234	2	primary	primary	ADJ
admet-2861	234	3	mechanism	mechanism	NOUN
admet-2861	234	4	that	that	PRON
admet-2861	234	5	can	can	AUX
admet-2861	234	6	explain	explain	VERB
admet-2861	234	7	the	the	DET
admet-2861	234	8	somewhat	somewhat	ADV
admet-2861	234	9	faster	fast	ADJ
admet-2861	234	10	release	release	NOUN
admet-2861	234	11	in	in	ADP
admet-2861	234	12	products	product	NOUN
admet-2861	234	13	s1	s1	NOUN
admet-2861	234	14	and	and	CCONJ
admet-2861	234	15	s3	s3	PROPN
admet-2861	234	16	is	be	AUX
admet-2861	234	17	the	the	DET
admet-2861	234	18	difference	difference	NOUN
admet-2861	234	19	in	in	ADP
admet-2861	234	20	the	the	DET
admet-2861	234	21	contact	contact	NOUN
admet-2861	234	22	angle	angle	NOUN
admet-2861	234	23	.	.	PROPN
admet-2861	234	24	it	it	PRON
admet-2861	234	25	has	have	AUX
admet-2861	234	26	been	be	AUX
admet-2861	234	27	shown	show	VERB
admet-2861	234	28	that	that	SCONJ
admet-2861	234	29	smaller	small	ADJ
admet-2861	234	30	particles	particle	NOUN
admet-2861	234	31	tend	tend	VERB
admet-2861	234	32	to	to	PART
admet-2861	234	33	exhibit	exhibit	VERB
admet-2861	234	34	larger	large	ADJ
admet-2861	234	35	contact	contact	NOUN
admet-2861	234	36	angles	angle	NOUN
admet-2861	234	37	with	with	ADP
admet-2861	234	38	the	the	DET
admet-2861	234	39	liquid	liquid	NOUN
admet-2861	234	40	,	,	PUNCT
admet-2861	234	41	resulting	result	VERB
admet-2861	234	42	in	in	ADP
admet-2861	234	43	reduced	reduce	VERB
admet-2861	234	44	wetting	wet	VERB
admet-2861	235	1	[	[	X
admet-2861	235	2	49,50	49,50	X
admet-2861	235	3	]	]	X
admet-2861	235	4	.	.	PUNCT
admet-2861	236	1	since	since	SCONJ
admet-2861	236	2	surface	surface	NOUN
admet-2861	236	3	wetting	wetting	NOUN
admet-2861	236	4	is	be	AUX
admet-2861	236	5	a	a	DET
admet-2861	236	6	prerequisite	prerequisite	NOUN
admet-2861	236	7	for	for	ADP
admet-2861	236	8	drug	drug	NOUN
admet-2861	236	9	dissolution	dissolution	NOUN
admet-2861	236	10	[	[	X
admet-2861	236	11	51	51	NUM
admet-2861	236	12	]	]	PUNCT
admet-2861	236	13	,	,	PUNCT
admet-2861	236	14	the	the	DET
admet-2861	236	15	increased	increase	VERB
admet-2861	236	16	contact	contact	NOUN
admet-2861	236	17	angle	angle	NOUN
admet-2861	236	18	for	for	ADP
admet-2861	236	19	smaller	small	ADJ
admet-2861	236	20	particles	particle	NOUN
admet-2861	236	21	in	in	ADP
admet-2861	236	22	products	product	NOUN
admet-2861	236	23	s2	s2	NOUN
admet-2861	236	24	and	and	CCONJ
admet-2861	236	25	s4	s4	PROPN
admet-2861	236	26	could	could	AUX
admet-2861	236	27	explain	explain	VERB
admet-2861	236	28	the	the	DET
admet-2861	236	29	slower	slow	ADJ
admet-2861	236	30	wetting	wetting	NOUN
admet-2861	236	31	and	and	CCONJ
admet-2861	236	32	dissolution	dissolution	NOUN
admet-2861	236	33	rates	rate	NOUN
admet-2861	236	34	.	.	PUNCT
admet-2861	237	1	this	this	DET
admet-2861	237	2	process	process	NOUN
admet-2861	237	3	contradicts	contradict	VERB
admet-2861	237	4	the	the	DET
admet-2861	237	5	common	common	ADJ
admet-2861	237	6	understanding	understanding	NOUN
admet-2861	237	7	that	that	SCONJ
admet-2861	237	8	,	,	PUNCT
admet-2861	237	9	with	with	ADP
admet-2861	237	10	decreasing	decrease	VERB
admet-2861	237	11	size	size	NOUN
admet-2861	237	12	,	,	PUNCT
admet-2861	237	13	the	the	DET
admet-2861	237	14	surface	surface	NOUN
admet-2861	237	15	area	area	NOUN
admet-2861	237	16	in	in	ADP
admet-2861	237	17	contact	contact	NOUN
admet-2861	237	18	with	with	ADP
admet-2861	237	19	the	the	DET
admet-2861	237	20	solvent	solvent	NOUN
admet-2861	237	21	increases	increase	NOUN
admet-2861	237	22	,	,	PUNCT
admet-2861	237	23	leading	lead	VERB
admet-2861	237	24	to	to	ADP
admet-2861	237	25	more	more	ADV
admet-2861	237	26	rapid	rapid	ADJ
admet-2861	237	27	dissolution	dissolution	NOUN
admet-2861	237	28	.	.	PUNCT
admet-2861	238	1	however	however	ADV
admet-2861	238	2	,	,	PUNCT
admet-2861	238	3	with	with	ADP
admet-2861	238	4	very	very	ADV
admet-2861	238	5	small	small	ADJ
admet-2861	238	6	particles	particle	NOUN
admet-2861	238	7	,	,	PUNCT
admet-2861	238	8	an	an	DET
admet-2861	238	9	interfering	interfere	VERB
admet-2861	238	10	process	process	NOUN
admet-2861	238	11	occurs	occur	VERB
admet-2861	238	12	where	where	SCONJ
admet-2861	238	13	decreasing	decrease	VERB
admet-2861	238	14	particle	particle	NOUN
admet-2861	238	15	size	size	NOUN
admet-2861	238	16	increases	increase	VERB
admet-2861	238	17	the	the	DET
admet-2861	238	18	wetting	wet	VERB
admet-2861	238	19	angle	angle	NOUN
admet-2861	238	20			NOUN
admet-2861	238	21	and	and	CCONJ
admet-2861	238	22	consequently	consequently	ADV
admet-2861	238	23	slows	slow	VERB
admet-2861	238	24	down	down	ADP
admet-2861	238	25	the	the	DET
admet-2861	238	26	dissolution	dissolution	NOUN
admet-2861	238	27	rate	rate	NOUN
admet-2861	238	28	due	due	ADP
admet-2861	238	29	to	to	ADP
admet-2861	238	30	the	the	DET
admet-2861	238	31	hindered	hinder	VERB
admet-2861	238	32	solventparticle	solventparticle	NOUN
admet-2861	238	33	contact	contact	NOUN
admet-2861	238	34	[	[	X
admet-2861	238	35	49,50	49,50	X
admet-2861	238	36	]	]	X
admet-2861	238	37	.	.	PUNCT
admet-2861	239	1	although	although	SCONJ
admet-2861	239	2	the	the	DET
admet-2861	239	3	mechanism	mechanism	NOUN
admet-2861	239	4	mentioned	mention	VERB
admet-2861	239	5	above	above	ADV
admet-2861	239	6	can	can	AUX
admet-2861	239	7	explain	explain	VERB
admet-2861	239	8	the	the	DET
admet-2861	239	9	observed	observed	ADJ
admet-2861	239	10	differences	difference	NOUN
admet-2861	239	11	in	in	ADP
admet-2861	239	12	sx	sx	PROPN
admet-2861	239	13	dissolution	dissolution	NOUN
admet-2861	239	14	rates	rate	NOUN
admet-2861	239	15	,	,	PUNCT
admet-2861	239	16	these	these	DET
admet-2861	239	17	differences	difference	NOUN
admet-2861	239	18	were	be	AUX
admet-2861	239	19	not	not	PART
admet-2861	239	20	significant	significant	ADJ
admet-2861	239	21	when	when	SCONJ
admet-2861	239	22	comparing	compare	VERB
admet-2861	239	23	the	the	DET
admet-2861	239	24	tested	test	VERB
admet-2861	239	25	products	product	NOUN
admet-2861	239	26	using	use	VERB
admet-2861	239	27	model	model	NOUN
admet-2861	239	28	-	-	PUNCT
admet-2861	239	29	independent	independent	ADJ
admet-2861	239	30	methods	method	NOUN
admet-2861	239	31	.	.	PUNCT
admet-2861	240	1	the	the	DET
admet-2861	240	2	absence	absence	NOUN
admet-2861	240	3	of	of	ADP
admet-2861	240	4	significant	significant	ADJ
admet-2861	240	5	differences	difference	NOUN
admet-2861	240	6	between	between	ADP
admet-2861	240	7	the	the	DET
admet-2861	240	8	obtained	obtain	VERB
admet-2861	240	9	profiles	profile	NOUN
admet-2861	240	10	(	(	PUNCT
admet-2861	240	11	tables	table	NOUN
admet-2861	240	12	4	4	NUM
admet-2861	240	13	and	and	CCONJ
admet-2861	240	14	5	5	NUM
admet-2861	240	15	)	)	PUNCT
admet-2861	240	16	suggests	suggest	VERB
admet-2861	240	17	that	that	SCONJ
admet-2861	240	18	biopharmaceutical	biopharmaceutical	NOUN
admet-2861	240	19	and	and	CCONJ
admet-2861	240	20	pharmaceutical	pharmaceutical	NOUN
admet-2861	240	21	-	-	PUNCT
admet-2861	240	22	technological	technological	ADJ
admet-2861	240	23	differences	difference	NOUN
admet-2861	240	24	between	between	ADP
admet-2861	240	25	the	the	DET
admet-2861	240	26	tested	test	VERB
admet-2861	240	27	products	product	NOUN
admet-2861	240	28	did	do	AUX
admet-2861	240	29	not	not	PART
admet-2861	240	30	significantly	significantly	ADV
admet-2861	240	31	impact	impact	VERB
admet-2861	240	32	sx	sx	PROPN
admet-2861	240	33	dissolution	dissolution	PROPN
admet-2861	240	34	,	,	PUNCT
admet-2861	240	35	indicating	indicate	VERB
admet-2861	240	36	that	that	SCONJ
admet-2861	240	37	the	the	DET
admet-2861	240	38	dissolution	dissolution	NOUN
admet-2861	240	39	process	process	NOUN
admet-2861	240	40	is	be	AUX
admet-2861	240	41	not	not	PART
admet-2861	240	42	a	a	DET
admet-2861	240	43	rate	rate	NOUN
admet-2861	240	44	-	-	PUNCT
admet-2861	240	45	limiting	limit	VERB
admet-2861	240	46	factor	factor	NOUN
admet-2861	240	47	for	for	ADP
admet-2861	240	48	sx	sx	PROPN
admet-2861	240	49	absorption	absorption	NOUN
admet-2861	240	50	.	.	PUNCT
admet-2861	241	1	the	the	DET
admet-2861	241	2	release	release	NOUN
admet-2861	241	3	profiles	profile	NOUN
admet-2861	241	4	were	be	AUX
admet-2861	241	5	compared	compare	VERB
admet-2861	241	6	using	use	VERB
admet-2861	241	7	model	model	NOUN
admet-2861	241	8	-	-	PUNCT
admet-2861	241	9	dependent	dependent	ADJ
admet-2861	241	10	methods	method	NOUN
admet-2861	241	11	,	,	PUNCT
admet-2861	241	12	and	and	CCONJ
admet-2861	241	13	the	the	DET
admet-2861	241	14	best	good	ADJ
admet-2861	241	15	correlation	correlation	NOUN
admet-2861	241	16	in	in	ADP
admet-2861	241	17	the	the	DET
admet-2861	241	18	case	case	NOUN
admet-2861	241	19	of	of	ADP
admet-2861	241	20	sx	sx	PROPN
admet-2861	241	21	was	be	AUX
admet-2861	241	22	obtained	obtain	VERB
admet-2861	241	23	for	for	ADP
admet-2861	241	24	the	the	DET
admet-2861	241	25	higuchi	higuchi	PROPN
admet-2861	241	26	kinetic	kinetic	ADJ
admet-2861	241	27	model	model	NOUN
admet-2861	241	28	(	(	PUNCT
admet-2861	241	29	table	table	NOUN
admet-2861	241	30	6	6	NUM
admet-2861	241	31	)	)	PUNCT
admet-2861	241	32	,	,	PUNCT
admet-2861	241	33	which	which	PRON
admet-2861	241	34	describes	describe	VERB
admet-2861	241	35	the	the	DET
admet-2861	241	36	release	release	NOUN
admet-2861	241	37	of	of	ADP
admet-2861	241	38	the	the	DET
admet-2861	241	39	substance	substance	NOUN
admet-2861	241	40	depending	depend	VERB
admet-2861	241	41	on	on	ADP
admet-2861	241	42	diffusion	diffusion	NOUN
admet-2861	241	43	through	through	ADP
admet-2861	241	44	the	the	DET
admet-2861	241	45	polymer	polymer	NOUN
admet-2861	241	46	matrix	matrix	NOUN
admet-2861	241	47	.	.	PUNCT
admet-2861	242	1	table	table	NOUN
admet-2861	242	2	6	6	NUM
admet-2861	242	3	.	.	PUNCT
admet-2861	243	1	analysis	analysis	NOUN
admet-2861	243	2	of	of	ADP
admet-2861	243	3	the	the	DET
admet-2861	243	4	dissolution	dissolution	ADJ
admet-2861	243	5	profiles	profile	NOUN
admet-2861	243	6	of	of	ADP
admet-2861	243	7	sx	sx	PROPN
admet-2861	243	8	with	with	ADP
admet-2861	243	9	model	model	NOUN
admet-2861	243	10	-	-	PUNCT
admet-2861	243	11	dependent	dependent	ADJ
admet-2861	243	12	models	model	NOUN
admet-2861	243	13	sample	sample	NOUN
admet-2861	243	14	model	model	NOUN
admet-2861	243	15	zero	zero	NUM
admet-2861	243	16	order	order	NOUN
admet-2861	243	17	first	first	ADJ
admet-2861	243	18	order	order	NOUN
admet-2861	243	19	hixson	hixson	PROPN
admet-2861	243	20	-	-	PUNCT
admet-2861	243	21	crowell	crowell	PROPN
admet-2861	243	22	higuchi	higuchi	PROPN
admet-2861	243	23	r2	r2	PROPN
admet-2861	243	24	s1	s1	PROPN
admet-2861	243	25	0.5901	0.5901	NUM
admet-2861	243	26	0.7191	0.7191	NUM
admet-2861	243	27	0.6779	0.6779	NUM
admet-2861	243	28	0.8291	0.8291	NUM
admet-2861	243	29	s2	s2	NOUN
admet-2861	243	30	0.7436	0.7436	NUM
admet-2861	243	31	0.8616	0.8616	NUM
admet-2861	243	32	0.8257	0.8257	NUM
admet-2861	243	33	0.9314	0.9314	NUM
admet-2861	243	34	s3	s3	NOUN
admet-2861	243	35	0.6169	0.6169	NUM
admet-2861	243	36	0.7453	0.7453	NUM
admet-2861	243	37	0.7050	0.7050	NUM
admet-2861	243	38	0.8490	0.8490	NUM
admet-2861	243	39	s4	s4	NOUN
admet-2861	243	40	0.7373	0.7373	NUM
admet-2861	243	41	0.8714	0.8714	NUM
admet-2861	243	42	0.8305	0.8305	NUM
admet-2861	243	43	0.9271	0.9271	NUM
admet-2861	243	44	these	these	DET
admet-2861	243	45	results	result	NOUN
admet-2861	243	46	support	support	VERB
admet-2861	243	47	the	the	DET
admet-2861	243	48	idea	idea	NOUN
admet-2861	243	49	that	that	SCONJ
admet-2861	243	50	the	the	DET
admet-2861	243	51	dissolution	dissolution	NOUN
admet-2861	243	52	rate	rate	NOUN
admet-2861	243	53	is	be	AUX
admet-2861	243	54	not	not	PART
admet-2861	243	55	the	the	DET
admet-2861	243	56	limiting	limit	VERB
admet-2861	243	57	factor	factor	NOUN
admet-2861	243	58	for	for	ADP
admet-2861	243	59	the	the	DET
admet-2861	243	60	absorption	absorption	NOUN
admet-2861	243	61	of	of	ADP
admet-2861	243	62	sx	sx	PROPN
admet-2861	243	63	from	from	ADP
admet-2861	243	64	inhalation	inhalation	NOUN
admet-2861	243	65	preparations	preparation	NOUN
admet-2861	243	66	;	;	PUNCT
admet-2861	243	67	rather	rather	ADV
admet-2861	243	68	,	,	PUNCT
admet-2861	243	69	the	the	DET
admet-2861	243	70	limiting	limit	VERB
admet-2861	243	71	factor	factor	NOUN
admet-2861	243	72	is	be	AUX
admet-2861	243	73	diffusion	diffusion	NOUN
admet-2861	243	74	,	,	PUNCT
admet-2861	243	75	specifically	specifically	ADV
admet-2861	243	76	through	through	ADP
admet-2861	243	77	the	the	DET
admet-2861	243	78	polymer	polymer	NOUN
admet-2861	243	79	matrix	matrix	NOUN
admet-2861	243	80	of	of	ADP
admet-2861	243	81	the	the	DET
admet-2861	243	82	agar	agar	NOUN
admet-2861	243	83	membrane	membrane	NOUN
admet-2861	243	84	.	.	PUNCT
admet-2861	244	1	no	no	DET
admet-2861	244	2	differences	difference	NOUN
admet-2861	244	3	were	be	AUX
admet-2861	244	4	found	find	VERB
admet-2861	244	5	among	among	ADP
admet-2861	244	6	the	the	DET
admet-2861	244	7	various	various	ADJ
admet-2861	244	8	sx	sx	NOUN
admet-2861	244	9	formulations	formulation	NOUN
admet-2861	244	10	when	when	SCONJ
admet-2861	244	11	compared	compare	VERB
admet-2861	244	12	using	use	VERB
admet-2861	244	13	model	model	NOUN
admet-2861	244	14	-	-	PUNCT
admet-2861	244	15	independent	independent	ADJ
admet-2861	244	16	models	model	NOUN
admet-2861	244	17	.	.	PUNCT
admet-2861	245	1	based	base	VERB
admet-2861	245	2	on	on	ADP
admet-2861	245	3	all	all	DET
admet-2861	245	4	this	this	PRON
admet-2861	245	5	,	,	PUNCT
admet-2861	245	6	we	we	PRON
admet-2861	245	7	can	can	AUX
admet-2861	245	8	conclude	conclude	VERB
admet-2861	245	9	that	that	SCONJ
admet-2861	245	10	the	the	DET
admet-2861	245	11	dissolution	dissolution	NOUN
admet-2861	245	12	of	of	ADP
admet-2861	245	13	sx	sx	PROPN
admet-2861	245	14	is	be	AUX
admet-2861	245	15	relatively	relatively	ADV
admet-2861	245	16	fast	fast	ADJ
admet-2861	245	17	and	and	CCONJ
admet-2861	245	18	that	that	SCONJ
admet-2861	245	19	the	the	DET
admet-2861	245	20	dissolution	dissolution	NOUN
admet-2861	245	21	rate	rate	NOUN
admet-2861	245	22	is	be	AUX
admet-2861	245	23	not	not	PART
admet-2861	245	24	a	a	DET
admet-2861	245	25	rate	rate	NOUN
admet-2861	245	26	-	-	PUNCT
admet-2861	245	27	limiting	limit	VERB
admet-2861	245	28	factor	factor	NOUN
admet-2861	245	29	in	in	ADP
admet-2861	245	30	the	the	DET
admet-2861	245	31	absorption	absorption	NOUN
admet-2861	245	32	of	of	ADP
admet-2861	245	33	sx	sx	PROPN
admet-2861	245	34	from	from	ADP
admet-2861	245	35	inhalation	inhalation	NOUN
admet-2861	245	36	products	product	NOUN
admet-2861	245	37	.	.	PUNCT
admet-2861	246	1	a	a	DET
admet-2861	246	2	similar	similar	ADJ
admet-2861	246	3	conclusion	conclusion	NOUN
admet-2861	246	4	about	about	ADP
admet-2861	246	5	the	the	DET
admet-2861	246	6	influence	influence	NOUN
admet-2861	246	7	of	of	ADP
admet-2861	246	8	dissolution	dissolution	ADJ
admet-2861	246	9	rate	rate	NOUN
admet-2861	246	10	on	on	ADP
admet-2861	246	11	absorption	absorption	NOUN
admet-2861	246	12	was	be	AUX
admet-2861	246	13	given	give	VERB
admet-2861	246	14	by	by	ADP
admet-2861	246	15	eriksson	eriksson	PROPN
admet-2861	246	16	et	et	PROPN
admet-2861	246	17	al	al	PROPN
admet-2861	246	18	.	.	PUNCT
admet-2861	247	1	[	[	X
admet-2861	247	2	52	52	NUM
admet-2861	247	3	]	]	PUNCT
admet-2861	247	4	when	when	SCONJ
admet-2861	247	5	examining	examine	VERB
admet-2861	247	6	pulmonary	pulmonary	ADJ
admet-2861	247	7	absorption	absorption	NOUN
admet-2861	247	8	in	in	ADP
admet-2861	247	9	models	model	NOUN
admet-2861	247	10	of	of	ADP
admet-2861	247	11	isolated	isolated	ADJ
admet-2861	247	12	rat	rat	NOUN
admet-2861	247	13	lungs	lung	NOUN
admet-2861	247	14	and	and	CCONJ
admet-2861	247	15	caco-2	caco-2	NUM
admet-2861	247	16	cell	cell	NOUN
admet-2861	247	17	monolayers	monolayer	NOUN
admet-2861	247	18	.	.	PUNCT
admet-2861	248	1	the	the	DET
admet-2861	248	2	dissolution	dissolution	ADJ
admet-2861	248	3	profiles	profile	NOUN
admet-2861	248	4	of	of	ADP
admet-2861	248	5	the	the	DET
admet-2861	248	6	products	product	NOUN
admet-2861	248	7	containing	contain	VERB
admet-2861	248	8	bdp	bdp	PROPN
admet-2861	248	9	are	be	AUX
admet-2861	248	10	shown	show	VERB
admet-2861	248	11	in	in	ADP
admet-2861	248	12	figure	figure	NOUN
admet-2861	248	13	9	9	NUM
admet-2861	248	14	.	.	PUNCT
admet-2861	249	1	the	the	DET
admet-2861	249	2	obtained	obtain	VERB
admet-2861	249	3	profiles	profile	NOUN
admet-2861	249	4	did	do	AUX
admet-2861	249	5	not	not	PART
admet-2861	249	6	reach	reach	VERB
admet-2861	249	7	an	an	DET
admet-2861	249	8	equilibrium	equilibrium	NOUN
admet-2861	249	9	plateau	plateau	NOUN
admet-2861	249	10	within	within	ADP
admet-2861	249	11	the	the	DET
admet-2861	249	12	experimental	experimental	ADJ
admet-2861	249	13	duration	duration	NOUN
admet-2861	249	14	of	of	ADP
admet-2861	249	15	the	the	DET
admet-2861	249	16	study	study	NOUN
admet-2861	249	17	(	(	PUNCT
admet-2861	249	18	4	4	NUM
admet-2861	249	19	h	h	NOUN
admet-2861	249	20	)	)	PUNCT
admet-2861	249	21	.	.	PUNCT
admet-2861	250	1	however	however	ADV
admet-2861	250	2	,	,	PUNCT
admet-2861	250	3	since	since	SCONJ
admet-2861	250	4	most	most	ADJ
admet-2861	250	5	small	small	ADJ
admet-2861	250	6	undissolved	undissolved	ADJ
admet-2861	250	7	particles	particle	NOUN
admet-2861	250	8	are	be	AUX
admet-2861	250	9	cleared	clear	VERB
admet-2861	250	10	from	from	ADP
admet-2861	250	11	the	the	DET
admet-2861	250	12	lungs	lung	NOUN
admet-2861	250	13	in	in	ADP
admet-2861	250	14	less	less	ADJ
admet-2861	250	15	than	than	ADP
admet-2861	250	16	4	4	NUM
admet-2861	250	17	hours	hour	NOUN
admet-2861	250	18	[	[	X
admet-2861	250	19	53	53	NUM
admet-2861	250	20	]	]	PUNCT
admet-2861	250	21	,	,	PUNCT
admet-2861	250	22	and	and	CCONJ
admet-2861	250	23	the	the	DET
admet-2861	250	24	absorption	absorption	NOUN
admet-2861	250	25	phase	phase	NOUN
admet-2861	250	26	of	of	ADP
admet-2861	250	27	bdp	bdp	PROPN
admet-2861	250	28	or	or	CCONJ
admet-2861	250	29	the	the	DET
admet-2861	250	30	tmax	tmax	NOUN
admet-2861	250	31	of	of	ADP
admet-2861	250	32	its	its	PRON
admet-2861	250	33	active	active	ADJ
admet-2861	250	34	metabolite	metabolite	NOUN
admet-2861	250	35	beclomethasone	beclomethasone	VERB
admet-2861	250	36	17	17	NUM
admet-2861	250	37	-	-	PUNCT
admet-2861	250	38	monopropionate	monopropionate	NOUN
admet-2861	250	39	(	(	PUNCT
admet-2861	250	40	bmp-17	bmp-17	NOUN
admet-2861	250	41	)	)	PUNCT
admet-2861	250	42	is	be	AUX
admet-2861	250	43	less	less	ADJ
admet-2861	250	44	than	than	ADP
admet-2861	250	45	4	4	NUM
admet-2861	250	46	hours	hour	NOUN
admet-2861	251	1	[	[	X
admet-2861	251	2	30,33	30,33	NUM
admet-2861	251	3	]	]	PUNCT
admet-2861	251	4	,	,	PUNCT
admet-2861	251	5	the	the	DET
admet-2861	251	6	duration	duration	NOUN
admet-2861	251	7	of	of	ADP
admet-2861	251	8	the	the	DET
admet-2861	251	9	test	test	NOUN
admet-2861	251	10	can	can	AUX
admet-2861	251	11	be	be	AUX
admet-2861	251	12	considered	consider	VERB
admet-2861	251	13	physiologically	physiologically	ADV
admet-2861	251	14	relevant	relevant	ADJ
admet-2861	251	15	.	.	PUNCT
admet-2861	252	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	252	2	a.	a.	PROPN
admet-2861	252	3	elezović	elezović	PROPN
admet-2861	252	4	et	et	PROPN
admet-2861	252	5	al	al	PROPN
admet-2861	252	6	.	.	PROPN
admet-2861	252	7	admet	admet	PROPN
admet-2861	252	8	&	&	CCONJ
admet-2861	252	9	dmpk	dmpk	PROPN
admet-2861	252	10	13(5	13(5	NUM
admet-2861	252	11	)	)	PUNCT
admet-2861	252	12	(	(	PUNCT
admet-2861	252	13	2025	2025	NUM
admet-2861	252	14	)	)	PUNCT
admet-2861	252	15	2861	2861	NUM
admet-2861	252	16	14	14	NUM
admet-2861	252	17	figure	figure	NOUN
admet-2861	252	18	9	9	NUM
admet-2861	252	19	.	.	PUNCT
admet-2861	253	1	dissolution	dissolution	ADJ
admet-2861	253	2	profiles	profile	NOUN
admet-2861	253	3	of	of	ADP
admet-2861	253	4	bdp	bdp	PROPN
admet-2861	253	5	samples	sample	NOUN
admet-2861	253	6	(	(	PUNCT
admet-2861	253	7	n	n	NOUN
admet-2861	253	8	=	=	SYM
admet-2861	253	9	3	3	NUM
admet-2861	253	10	,	,	PUNCT
admet-2861	253	11	mean	mean	VERB
admet-2861	253	12	±	±	NUM
admet-2861	253	13	sd	sd	NOUN
admet-2861	253	14	)	)	PUNCT
admet-2861	253	15	the	the	DET
admet-2861	253	16	difference	difference	NOUN
admet-2861	253	17	in	in	ADP
admet-2861	253	18	drug	drug	NOUN
admet-2861	253	19	release	release	NOUN
admet-2861	253	20	curves	curve	NOUN
admet-2861	253	21	from	from	ADP
admet-2861	253	22	the	the	DET
admet-2861	253	23	tested	test	VERB
admet-2861	253	24	products	product	NOUN
admet-2861	253	25	and	and	CCONJ
admet-2861	253	26	the	the	DET
admet-2861	253	27	solution	solution	NOUN
admet-2861	253	28	suggests	suggest	VERB
admet-2861	253	29	that	that	SCONJ
admet-2861	253	30	dissolution	dissolution	NOUN
admet-2861	253	31	is	be	AUX
admet-2861	253	32	the	the	DET
admet-2861	253	33	rate	rate	NOUN
admet-2861	253	34	-	-	PUNCT
admet-2861	253	35	limiting	limit	VERB
admet-2861	253	36	factor	factor	NOUN
admet-2861	253	37	for	for	ADP
admet-2861	253	38	absorption	absorption	NOUN
admet-2861	253	39	.	.	PUNCT
admet-2861	254	1	similar	similar	ADJ
admet-2861	254	2	observations	observation	NOUN
admet-2861	254	3	have	have	AUX
admet-2861	254	4	been	be	AUX
admet-2861	254	5	made	make	VERB
admet-2861	254	6	for	for	ADP
admet-2861	254	7	other	other	ADJ
admet-2861	254	8	poorly	poorly	ADV
admet-2861	254	9	soluble	soluble	ADJ
admet-2861	254	10	substances	substance	NOUN
admet-2861	254	11	formulated	formulate	VERB
admet-2861	254	12	as	as	ADP
admet-2861	254	13	inhalation	inhalation	NOUN
admet-2861	254	14	products	product	NOUN
admet-2861	254	15	[	[	X
admet-2861	254	16	14,54	14,54	NUM
admet-2861	254	17	]	]	X
admet-2861	254	18	.	.	PUNCT
admet-2861	255	1	the	the	DET
admet-2861	255	2	differences	difference	NOUN
admet-2861	255	3	in	in	ADP
admet-2861	255	4	the	the	DET
admet-2861	255	5	slopes	slope	NOUN
admet-2861	255	6	obtained	obtain	VERB
admet-2861	255	7	from	from	ADP
admet-2861	255	8	the	the	DET
admet-2861	255	9	release	release	NOUN
admet-2861	255	10	curves	curve	NOUN
admet-2861	255	11	indicate	indicate	VERB
admet-2861	255	12	the	the	DET
admet-2861	255	13	potential	potential	ADJ
admet-2861	255	14	differences	difference	NOUN
admet-2861	255	15	in	in	ADP
admet-2861	255	16	the	the	DET
admet-2861	255	17	rate	rate	NOUN
admet-2861	255	18	and	and	CCONJ
admet-2861	255	19	extent	extent	NOUN
admet-2861	255	20	of	of	ADP
admet-2861	255	21	bdp	bdp	PROPN
admet-2861	255	22	release	release	NOUN
admet-2861	255	23	from	from	ADP
admet-2861	255	24	the	the	DET
admet-2861	255	25	tested	test	VERB
admet-2861	255	26	preparations	preparation	NOUN
admet-2861	255	27	.	.	PUNCT
admet-2861	256	1	the	the	DET
admet-2861	256	2	obtained	obtain	VERB
admet-2861	256	3	release	release	NOUN
admet-2861	256	4	profiles	profile	NOUN
admet-2861	256	5	of	of	ADP
admet-2861	256	6	the	the	DET
admet-2861	256	7	bdp	bdp	PROPN
admet-2861	256	8	products	product	NOUN
admet-2861	256	9	showed	show	VERB
admet-2861	256	10	the	the	DET
admet-2861	256	11	highest	high	ADJ
admet-2861	256	12	correlation	correlation	NOUN
admet-2861	256	13	with	with	ADP
admet-2861	256	14	the	the	DET
admet-2861	256	15	first	first	ADJ
admet-2861	256	16	-	-	PUNCT
admet-2861	256	17	order	order	NOUN
admet-2861	256	18	kinetics	kinetic	NOUN
admet-2861	256	19	and	and	CCONJ
admet-2861	256	20	the	the	DET
admet-2861	256	21	hixon	hixon	NOUN
admet-2861	256	22	-	-	PUNCT
admet-2861	256	23	crowell	crowell	NOUN
admet-2861	256	24	model	model	NOUN
admet-2861	256	25	(	(	PUNCT
admet-2861	256	26	table	table	NOUN
admet-2861	256	27	7	7	NUM
admet-2861	256	28	)	)	PUNCT
admet-2861	256	29	.	.	PUNCT
admet-2861	257	1	table	table	NOUN
admet-2861	257	2	7	7	NUM
admet-2861	257	3	.	.	PUNCT
admet-2861	258	1	analysis	analysis	NOUN
admet-2861	258	2	of	of	ADP
admet-2861	258	3	the	the	DET
admet-2861	258	4	dissolution	dissolution	ADJ
admet-2861	258	5	profile	profile	NOUN
admet-2861	258	6	of	of	ADP
admet-2861	258	7	bdp	bdp	PROPN
admet-2861	258	8	by	by	ADP
admet-2861	258	9	model	model	NOUN
admet-2861	258	10	-	-	PUNCT
admet-2861	258	11	dependent	dependent	ADJ
admet-2861	258	12	methods	method	NOUN
admet-2861	258	13	correlation	correlation	NOUN
admet-2861	258	14	coefficients	coefficient	NOUN
admet-2861	258	15	(	(	PUNCT
admet-2861	258	16	r2	r2	PROPN
admet-2861	258	17	)	)	PUNCT
admet-2861	258	18	of	of	ADP
admet-2861	258	19	the	the	DET
admet-2861	258	20	dissolution	dissolution	NOUN
admet-2861	258	21	profile	profile	NOUN
admet-2861	258	22	with	with	ADP
admet-2861	258	23	different	different	ADJ
admet-2861	258	24	release	release	NOUN
admet-2861	258	25	kinetics	kinetic	NOUN
admet-2861	258	26	models	model	NOUN
admet-2861	258	27	sample	sample	NOUN
admet-2861	258	28	model	model	NOUN
admet-2861	258	29	zero	zero	NUM
admet-2861	258	30	order	order	NOUN
admet-2861	258	31	first	first	ADJ
admet-2861	258	32	order	order	NOUN
admet-2861	258	33	hixson	hixson	PROPN
admet-2861	258	34	-	-	PUNCT
admet-2861	258	35	crowell	crowell	PROPN
admet-2861	258	36	higuchi	higuchi	PROPN
admet-2861	258	37	r2	r2	PROPN
admet-2861	258	38	b1	b1	NOUN
admet-2861	258	39	0.9733	0.9733	NUM
admet-2861	259	1	0.9935	0.9935	NUM
admet-2861	259	2	0.9883	0.9883	NUM
admet-2861	259	3	0.9834	0.9834	NUM
admet-2861	259	4	b2	b2	NOUN
admet-2861	259	5	0.9656	0.9656	NUM
admet-2861	259	6	0.9931	0.9931	NUM
admet-2861	259	7	0.9862	0.9862	NUM
admet-2861	259	8	0.9110	0.9110	NUM
admet-2861	259	9	b3	b3	NOUN
admet-2861	259	10	0.9750	0.9750	NUM
admet-2861	259	11	0.9995	0.9995	NUM
admet-2861	259	12	0.9971	0.9971	NUM
admet-2861	259	13	0.9847	0.9847	NUM
admet-2861	259	14	these	these	DET
admet-2861	259	15	results	result	NOUN
admet-2861	259	16	show	show	VERB
admet-2861	259	17	that	that	SCONJ
admet-2861	259	18	the	the	DET
admet-2861	259	19	bdp	bdp	PROPN
admet-2861	259	20	release	release	NOUN
admet-2861	259	21	was	be	AUX
admet-2861	259	22	regulated	regulate	VERB
admet-2861	259	23	by	by	ADP
admet-2861	259	24	the	the	DET
admet-2861	259	25	concentration	concentration	NOUN
admet-2861	259	26	of	of	ADP
admet-2861	259	27	the	the	DET
admet-2861	259	28	active	active	ADJ
admet-2861	259	29	substance	substance	NOUN
admet-2861	259	30	(	(	PUNCT
admet-2861	259	31	firstorder	firstorder	NOUN
admet-2861	259	32	kinetics	kinetic	NOUN
admet-2861	259	33	)	)	PUNCT
admet-2861	259	34	and	and	CCONJ
admet-2861	259	35	the	the	DET
admet-2861	259	36	dissolution	dissolution	ADJ
admet-2861	259	37	rate	rate	NOUN
admet-2861	259	38	of	of	ADP
admet-2861	259	39	bdp	bdp	PROPN
admet-2861	259	40	particles	particle	NOUN
admet-2861	259	41	(	(	PUNCT
admet-2861	259	42	hixon	hixon	NOUN
admet-2861	259	43	-	-	PUNCT
admet-2861	259	44	crowell	crowell	NOUN
admet-2861	259	45	model	model	NOUN
admet-2861	259	46	)	)	PUNCT
admet-2861	259	47	,	,	PUNCT
admet-2861	259	48	and	and	CCONJ
admet-2861	259	49	it	it	PRON
admet-2861	259	50	was	be	AUX
admet-2861	259	51	less	less	ADV
admet-2861	259	52	dependent	dependent	ADJ
admet-2861	259	53	on	on	ADP
admet-2861	259	54	diffusion	diffusion	NOUN
admet-2861	259	55	through	through	ADP
admet-2861	259	56	the	the	DET
admet-2861	259	57	agar	agar	NOUN
admet-2861	259	58	gel	gel	NOUN
admet-2861	259	59	(	(	PUNCT
admet-2861	259	60	higuchi	higuchi	PROPN
admet-2861	259	61	model	model	PROPN
admet-2861	259	62	)	)	PUNCT
admet-2861	259	63	.	.	PUNCT
admet-2861	260	1	comparison	comparison	NOUN
admet-2861	260	2	of	of	ADP
admet-2861	260	3	the	the	DET
admet-2861	260	4	dissolution	dissolution	ADJ
admet-2861	260	5	profiles	profile	NOUN
admet-2861	260	6	of	of	ADP
admet-2861	260	7	bdp	bdp	PROPN
admet-2861	260	8	based	base	VERB
admet-2861	260	9	on	on	ADP
admet-2861	260	10	difference	difference	NOUN
admet-2861	260	11	and	and	CCONJ
admet-2861	260	12	similarity	similarity	NOUN
admet-2861	260	13	factors	factor	NOUN
admet-2861	260	14	(	(	PUNCT
admet-2861	260	15	f1	f1	NOUN
admet-2861	260	16	and	and	CCONJ
admet-2861	260	17	f2	f2	PROPN
admet-2861	260	18	respectively	respectively	ADV
admet-2861	260	19	)	)	PUNCT
admet-2861	260	20	indicated	indicate	VERB
admet-2861	260	21	statistically	statistically	ADV
admet-2861	260	22	significant	significant	ADJ
admet-2861	260	23	differences	difference	NOUN
admet-2861	260	24	among	among	ADP
admet-2861	260	25	the	the	DET
admet-2861	260	26	tested	test	VERB
admet-2861	260	27	products	product	NOUN
admet-2861	260	28	(	(	PUNCT
admet-2861	260	29	table	table	NOUN
admet-2861	260	30	8)	8)	NUM
admet-2861	260	31	.	.	PUNCT
admet-2861	260	32	table	table	NOUN
admet-2861	260	33	8	8	NUM
admet-2861	260	34	.	.	PUNCT
admet-2861	260	35	results	result	NOUN
admet-2861	260	36	of	of	ADP
admet-2861	260	37	comparison	comparison	NOUN
admet-2861	260	38	of	of	ADP
admet-2861	260	39	bdp	bdp	PROPN
admet-2861	260	40	dissolution	dissolution	PROPN
admet-2861	260	41	curves	curve	NOUN
admet-2861	260	42	from	from	ADP
admet-2861	260	43	tested	test	VERB
admet-2861	260	44	products	product	NOUN
admet-2861	260	45	using	use	VERB
admet-2861	260	46	model	model	NOUN
admet-2861	260	47	-	-	PUNCT
admet-2861	260	48	independent	independent	ADJ
admet-2861	260	49	methods	method	NOUN
admet-2861	260	50	compared	compare	VERB
admet-2861	260	51	dissolution	dissolution	ADJ
admet-2861	260	52	curves	curve	NOUN
admet-2861	260	53	:	:	PUNCT
admet-2861	260	54	f1	f1	NOUN
admet-2861	260	55	f2	f2	PROPN
admet-2861	260	56	b1	b1	NOUN
admet-2861	260	57	b2	b2	NOUN
admet-2861	260	58	16.9	16.9	NUM
admet-2861	260	59	61.4	61.4	NUM
admet-2861	260	60	b2	b2	NOUN
admet-2861	260	61	b1	b1	NOUN
admet-2861	260	62	20.4	20.4	NUM
admet-2861	260	63	b1	b1	NOUN
admet-2861	260	64	–	–	PUNCT
admet-2861	260	65	b3	b3	NOUN
admet-2861	260	66	32.4	32.4	NUM
admet-2861	260	67	40.7	40.7	NUM
admet-2861	260	68	b3	b3	PROPN
admet-2861	260	69	b1	b1	NOUN
admet-2861	260	70	47.9	47.9	NUM
admet-2861	260	71	b2	b2	NOUN
admet-2861	260	72	–	–	PUNCT
admet-2861	260	73	b3	b3	NOUN
admet-2861	260	74	19.2	19.2	NUM
admet-2861	260	75	50.5	50.5	NUM
admet-2861	260	76	b3	b3	NOUN
admet-2861	260	77	–	–	PUNCT
admet-2861	260	78	b2	b2	NOUN
admet-2861	260	79	23.6	23.6	NUM
admet-2861	260	80	although	although	SCONJ
admet-2861	260	81	the	the	DET
admet-2861	260	82	difference	difference	NOUN
admet-2861	260	83	factor	factor	NOUN
admet-2861	260	84	(	(	PUNCT
admet-2861	260	85	f1	f1	NOUN
admet-2861	260	86	)	)	PUNCT
admet-2861	260	87	showed	show	VERB
admet-2861	260	88	significant	significant	ADJ
admet-2861	260	89	differences	difference	NOUN
admet-2861	260	90	between	between	ADP
admet-2861	260	91	all	all	DET
admet-2861	260	92	three	three	NUM
admet-2861	260	93	formulations	formulation	NOUN
admet-2861	260	94	(	(	PUNCT
admet-2861	260	95	f1	f1	NOUN
admet-2861	260	96	>	>	X
admet-2861	260	97	15	15	NUM
admet-2861	260	98	)	)	PUNCT
admet-2861	260	99	,	,	PUNCT
admet-2861	260	100	the	the	DET
admet-2861	260	101	similarity	similarity	NOUN
admet-2861	260	102	factor	factor	NOUN
admet-2861	260	103	(	(	PUNCT
admet-2861	260	104	f2	f2	PROPN
admet-2861	260	105	)	)	PUNCT
admet-2861	260	106	showed	show	VERB
admet-2861	260	107	a	a	DET
admet-2861	260	108	difference	difference	NOUN
admet-2861	260	109	only	only	ADV
admet-2861	260	110	between	between	ADP
admet-2861	260	111	products	product	NOUN
admet-2861	260	112	b1	b1	NOUN
admet-2861	260	113	and	and	CCONJ
admet-2861	260	114	b3	b3	PROPN
admet-2861	260	115	(	(	PUNCT
admet-2861	260	116	f2	f2	X
admet-2861	260	117	<	<	X
admet-2861	260	118	50	50	NUM
admet-2861	260	119	)	)	PUNCT
admet-2861	260	120	.	.	PUNCT
admet-2861	261	1	the	the	DET
admet-2861	261	2	results	result	NOUN
admet-2861	261	3	indicate	indicate	VERB
admet-2861	261	4	that	that	SCONJ
admet-2861	261	5	the	the	DET
admet-2861	261	6	similarity	similarity	NOUN
admet-2861	261	7	factor	factor	NOUN
admet-2861	261	8	is	be	AUX
admet-2861	261	9	more	more	ADV
admet-2861	261	10	adequate	adequate	ADJ
admet-2861	261	11	in	in	ADP
admet-2861	261	12	detecting	detect	VERB
admet-2861	261	13	differences	difference	NOUN
admet-2861	261	14	in	in	ADP
admet-2861	261	15	the	the	DET
admet-2861	261	16	release	release	NOUN
admet-2861	261	17	profiles	profile	NOUN
admet-2861	261	18	of	of	ADP
admet-2861	261	19	bdp	bdp	PROPN
admet-2861	261	20	,	,	PUNCT
admet-2861	261	21	a	a	DET
admet-2861	261	22	poorly	poorly	ADV
admet-2861	261	23	soluble	soluble	ADJ
admet-2861	261	24	substance	substance	NOUN
admet-2861	261	25	,	,	PUNCT
admet-2861	261	26	and	and	CCONJ
admet-2861	261	27	suggest	suggest	VERB
admet-2861	261	28	that	that	SCONJ
admet-2861	261	29	the	the	DET
admet-2861	261	30	proposed	propose	VERB
admet-2861	261	31	method	method	NOUN
admet-2861	261	32	can	can	AUX
admet-2861	261	33	reveal	reveal	VERB
admet-2861	261	34	differences	difference	NOUN
admet-2861	261	35	in	in	ADP
admet-2861	261	36	the	the	DET
admet-2861	261	37	dissolution	dissolution	ADJ
admet-2861	261	38	profiles	profile	NOUN
admet-2861	261	39	of	of	ADP
admet-2861	261	40	various	various	ADJ
admet-2861	261	41	inhalation	inhalation	NOUN
admet-2861	261	42	products	product	NOUN
admet-2861	261	43	containing	contain	VERB
admet-2861	261	44	the	the	DET
admet-2861	261	45	same	same	ADJ
admet-2861	261	46	active	active	ADJ
admet-2861	261	47	ingredient	ingredient	NOUN
admet-2861	261	48	.	.	PUNCT
admet-2861	262	1	this	this	PRON
admet-2861	262	2	is	be	AUX
admet-2861	262	3	particularly	particularly	ADV
admet-2861	262	4	important	important	ADJ
admet-2861	262	5	when	when	SCONJ
admet-2861	262	6	admet	admet	PROPN
admet-2861	262	7	&	&	CCONJ
admet-2861	262	8	dmpk	dmpk	PROPN
admet-2861	262	9	13	13	NUM
admet-2861	262	10	(	(	PUNCT
admet-2861	262	11	)	)	PUNCT
admet-2861	262	12	(	(	PUNCT
admet-2861	262	13	2025	2025	NUM
admet-2861	262	14	)	)	PUNCT
admet-2861	262	15	2861	2861	NUM
admet-2861	262	16	development	development	NOUN
admet-2861	262	17	of	of	ADP
admet-2861	262	18	a	a	DET
admet-2861	262	19	biorelevant	biorelevant	ADJ
admet-2861	262	20	dissolution	dissolution	NOUN
admet-2861	262	21	method	method	NOUN
admet-2861	262	22	for	for	ADP
admet-2861	262	23	inhalation	inhalation	NOUN
admet-2861	262	24	products	product	NOUN
admet-2861	262	25	doi	doi	NOUN
admet-2861	262	26	:	:	PUNCT
admet-2861	262	27	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	262	28	15	15	NUM
admet-2861	262	29	compared	compare	VERB
admet-2861	262	30	with	with	ADP
admet-2861	262	31	the	the	DET
admet-2861	262	32	results	result	NOUN
admet-2861	262	33	of	of	ADP
admet-2861	262	34	the	the	DET
admet-2861	262	35	aerodynamic	aerodynamic	ADJ
admet-2861	262	36	particle	particle	NOUN
admet-2861	262	37	size	size	NOUN
admet-2861	262	38	distribution	distribution	NOUN
admet-2861	262	39	and	and	CCONJ
admet-2861	262	40	the	the	DET
admet-2861	262	41	differences	difference	NOUN
admet-2861	262	42	in	in	ADP
admet-2861	262	43	the	the	DET
admet-2861	262	44	amount	amount	NOUN
admet-2861	262	45	of	of	ADP
admet-2861	262	46	bdp	bdp	PROPN
admet-2861	262	47	deposited	deposit	VERB
admet-2861	262	48	at	at	ADP
admet-2861	262	49	the	the	DET
admet-2861	262	50	ngi	ngi	PROPN
admet-2861	262	51	stages	stage	NOUN
admet-2861	262	52	.	.	PUNCT
admet-2861	263	1	as	as	SCONJ
admet-2861	263	2	can	can	AUX
admet-2861	263	3	be	be	AUX
admet-2861	263	4	seen	see	VERB
admet-2861	263	5	in	in	ADP
admet-2861	263	6	table	table	NOUN
admet-2861	263	7	1	1	NUM
admet-2861	263	8	and	and	CCONJ
admet-2861	263	9	figure	figure	NOUN
admet-2861	263	10	1	1	NUM
admet-2861	263	11	,	,	PUNCT
admet-2861	263	12	the	the	DET
admet-2861	263	13	largest	large	ADJ
admet-2861	263	14	difference	difference	NOUN
admet-2861	263	15	was	be	AUX
admet-2861	263	16	observed	observe	VERB
admet-2861	263	17	between	between	ADP
admet-2861	263	18	products	product	NOUN
admet-2861	263	19	b1	b1	NOUN
admet-2861	263	20	and	and	CCONJ
admet-2861	263	21	b3	b3	PROPN
admet-2861	263	22	,	,	PUNCT
admet-2861	263	23	which	which	PRON
admet-2861	263	24	aligns	align	VERB
admet-2861	263	25	with	with	ADP
admet-2861	263	26	the	the	DET
admet-2861	263	27	results	result	NOUN
admet-2861	263	28	of	of	ADP
admet-2861	263	29	the	the	DET
admet-2861	263	30	dissolution	dissolution	NOUN
admet-2861	263	31	study	study	NOUN
admet-2861	263	32	.	.	PUNCT
admet-2861	264	1	a	a	DET
admet-2861	264	2	two	two	NUM
admet-2861	264	3	-	-	PUNCT
admet-2861	264	4	compartment	compartment	NOUN
admet-2861	264	5	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	264	6	model	model	NOUN
admet-2861	264	7	was	be	AUX
admet-2861	264	8	created	create	VERB
admet-2861	264	9	using	use	VERB
admet-2861	264	10	gastroplus	gastroplus	ADJ
admet-2861	264	11	™	™	ADJ
admet-2861	264	12	software	software	NOUN
admet-2861	264	13	.	.	PUNCT
admet-2861	265	1	the	the	DET
admet-2861	265	2	model	model	NOUN
admet-2861	265	3	was	be	AUX
admet-2861	265	4	based	base	VERB
admet-2861	265	5	on	on	ADP
admet-2861	265	6	the	the	DET
admet-2861	265	7	results	result	NOUN
admet-2861	265	8	of	of	ADP
admet-2861	265	9	in	in	ADP
admet-2861	265	10	vivo	vivo	ADJ
admet-2861	265	11	studies	study	NOUN
admet-2861	265	12	published	publish	VERB
admet-2861	265	13	in	in	ADP
admet-2861	265	14	the	the	DET
admet-2861	265	15	literature	literature	NOUN
admet-2861	265	16	[	[	X
admet-2861	265	17	30,32,33	30,32,33	NUM
admet-2861	265	18	]	]	PUNCT
admet-2861	265	19	.	.	PUNCT
admet-2861	266	1	the	the	DET
admet-2861	266	2	obtained	obtain	VERB
admet-2861	266	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	266	4	parameters	parameter	NOUN
admet-2861	266	5	were	be	AUX
admet-2861	266	6	used	use	VERB
admet-2861	266	7	in	in	ADP
admet-2861	266	8	combination	combination	NOUN
admet-2861	266	9	with	with	ADP
admet-2861	266	10	the	the	DET
admet-2861	266	11	data	datum	NOUN
admet-2861	266	12	defining	define	VERB
admet-2861	266	13	the	the	DET
admet-2861	266	14	properties	property	NOUN
admet-2861	266	15	of	of	ADP
admet-2861	266	16	the	the	DET
admet-2861	266	17	test	test	NOUN
admet-2861	266	18	substances	substance	NOUN
admet-2861	266	19	(	(	PUNCT
admet-2861	266	20	table	table	NOUN
admet-2861	266	21	9	9	NUM
admet-2861	266	22	)	)	PUNCT
admet-2861	266	23	to	to	PART
admet-2861	266	24	generate	generate	VERB
admet-2861	266	25	the	the	DET
admet-2861	266	26	expected	expect	VERB
admet-2861	266	27	cp	cp	PROPN
admet-2861	266	28	-	-	PUNCT
admet-2861	266	29	t	t	NOUN
admet-2861	266	30	curves	curve	NOUN
admet-2861	266	31	data	datum	NOUN
admet-2861	266	32	for	for	ADP
admet-2861	266	33	intravenously	intravenously	ADV
admet-2861	266	34	(	(	PUNCT
admet-2861	266	35	i.v	i.v	X
admet-2861	266	36	.	.	PUNCT
admet-2861	266	37	)	)	PUNCT
admet-2861	266	38	and	and	CCONJ
admet-2861	266	39	orally	orally	ADV
admet-2861	266	40	administered	administer	VERB
admet-2861	266	41	(	(	PUNCT
admet-2861	266	42	p.o	p.o	PROPN
admet-2861	266	43	.	.	PROPN
admet-2861	266	44	)	)	PUNCT
admet-2861	266	45	bdp	bdp	PROPN
admet-2861	266	46	and	and	CCONJ
admet-2861	266	47	its	its	PRON
admet-2861	266	48	main	main	ADJ
admet-2861	266	49	active	active	ADJ
admet-2861	266	50	metabolite	metabolite	NOUN
admet-2861	266	51	,	,	PUNCT
admet-2861	266	52	bmp-17	bmp-17	X
admet-2861	266	53	.	.	NOUN
admet-2861	266	54	table	table	NOUN
admet-2861	266	55	9	9	NUM
admet-2861	266	56	.	.	PUNCT
admet-2861	267	1	data	datum	NOUN
admet-2861	267	2	used	use	VERB
admet-2861	267	3	for	for	ADP
admet-2861	267	4	the	the	DET
admet-2861	267	5	creation	creation	NOUN
admet-2861	267	6	of	of	ADP
admet-2861	267	7	in	in	ADP
admet-2861	267	8	silico	silico	NOUN
admet-2861	267	9	model	model	NOUN
admet-2861	267	10	for	for	ADP
admet-2861	267	11	bdp	bdp	PROPN
admet-2861	267	12	and	and	CCONJ
admet-2861	267	13	bmp-17	bmp-17	ADP
admet-2861	267	14	bdp	bdp	PROPN
admet-2861	267	15	i.v	i.v	PROPN
admet-2861	267	16	.	.	PROPN
admet-2861	268	1	bmp-17	bmp-17	PROPN
admet-2861	268	2	bdp	bdp	PROPN
admet-2861	268	3	p.o	p.o	PROPN
admet-2861	268	4	.	.	PROPN
admet-2861	268	5	/	/	PUNCT
admet-2861	268	6	bmp-17	bmp-17	ADP
admet-2861	268	7	mr	mr	PROPN
admet-2861	268	8	/	/	SYM
admet-2861	268	9	g	g	PROPN
admet-2861	268	10	mol-1	mol-1	ADP
admet-2861	268	11	521.1	521.1	NUM
admet-2861	268	12	[	[	SYM
admet-2861	268	13	41	41	NUM
admet-2861	268	14	]	]	PUNCT
admet-2861	268	15	465.0	465.0	NUM
admet-2861	269	1	[	[	X
admet-2861	269	2	55	55	NUM
admet-2861	269	3	]	]	PUNCT
admet-2861	269	4	521.1	521.1	NUM
admet-2861	269	5	[	[	SYM
admet-2861	269	6	41	41	NUM
admet-2861	269	7	]	]	PUNCT
admet-2861	269	8	log	log	NOUN
admet-2861	269	9	p	p	NOUN
admet-2861	269	10	1.30	1.30	NUM
admet-2861	269	11	[	[	X
admet-2861	269	12	56	56	NUM
admet-2861	269	13	]	]	SYM
admet-2861	269	14	2.46	2.46	NUM
admet-2861	270	1	[	[	X
admet-2861	270	2	55	55	NUM
admet-2861	270	3	]	]	SYM
admet-2861	270	4	1.30	1.30	NUM
admet-2861	271	1	[	[	X
admet-2861	271	2	55	55	NUM
admet-2861	271	3	]	]	X
admet-2861	271	4	pka	pka	PROPN
admet-2861	271	5	-3.3	-3.3	PROPN
admet-2861	271	6	(	(	PUNCT
admet-2861	271	7	base	base	NOUN
admet-2861	271	8	)	)	PUNCT
admet-2861	271	9	13.85	13.85	NUM
admet-2861	271	10	(	(	PUNCT
admet-2861	271	11	acid	acid	NOUN
admet-2861	271	12	)	)	PUNCT
admet-2861	272	1	[	[	X
admet-2861	272	2	41	41	NUM
admet-2861	272	3	]	]	SYM
admet-2861	272	4	-3.3	-3.3	PROPN
admet-2861	272	5	(	(	PUNCT
admet-2861	272	6	base	base	NOUN
admet-2861	272	7	)	)	PUNCT
admet-2861	272	8	13.85	13.85	NUM
admet-2861	272	9	(	(	PUNCT
admet-2861	272	10	acid	acid	NOUN
admet-2861	272	11	)	)	PUNCT
admet-2861	273	1	[	[	X
admet-2861	273	2	55	55	NUM
admet-2861	273	3	]	]	SYM
admet-2861	273	4	-3.3	-3.3	PROPN
admet-2861	273	5	(	(	PUNCT
admet-2861	273	6	base	base	NOUN
admet-2861	273	7	)	)	PUNCT
admet-2861	273	8	13.85	13.85	NUM
admet-2861	273	9	(	(	PUNCT
admet-2861	273	10	acid	acid	NOUN
admet-2861	273	11	)	)	PUNCT
admet-2861	274	1	[	[	X
admet-2861	274	2	41	41	NUM
admet-2861	274	3	]	]	X
admet-2861	274	4	solubility	solubility	NOUN
admet-2861	274	5	/	/	SYM
admet-2861	274	6	mg	mg	PROPN
admet-2861	274	7	ml-1	ml-1	ADV
admet-2861	274	8	@ph	@ph	PROPN
admet-2861	274	9	7	7	NUM
admet-2861	274	10	0.00208	0.00208	NUM
admet-2861	274	11	[	[	X
admet-2861	274	12	56	56	NUM
admet-2861	274	13	]	]	SYM
admet-2861	274	14	0.04570	0.04570	NUM
admet-2861	274	15	[	[	X
admet-2861	274	16	57	57	NUM
admet-2861	274	17	]	]	SYM
admet-2861	274	18	0.00030	0.00030	NUM
admet-2861	274	19	*	*	PUNCT
admet-2861	274	20	diffusion	diffusion	NOUN
admet-2861	274	21	coefficient	coefficient	NOUN
admet-2861	274	22	,	,	PUNCT
admet-2861	274	23	cm2	cm2	PROPN
admet-2861	274	24	s10	s10	NOUN
admet-2861	274	25	-	-	PUNCT
admet-2861	274	26	5	5	NUM
admet-2861	275	1	0.7500	0.7500	NUM
admet-2861	275	2	0.6072	0.6072	NUM
admet-2861	275	3	0.5712	0.5712	NUM
admet-2861	275	4	vca	vca	NOUN
admet-2861	275	5	/	/	SYM
admet-2861	275	6	l	l	PROPN
admet-2861	275	7	kg-1	kg-1	NOUN
admet-2861	275	8	0.080f	0.080f	NOUN
admet-2861	275	9	3.725	3.725	NUM
admet-2861	275	10	f	f	NOUN
admet-2861	275	11	6.000	6.000	NUM
admet-2861	275	12	f	f	PROPN
admet-2861	275	13	clb/	clb/	PROPN
admet-2861	275	14	l	l	PROPN
admet-2861	275	15	h-1	h-1	NOUN
admet-2861	275	16	99.84	99.84	NUM
admet-2861	276	1	[	[	X
admet-2861	276	2	30	30	NUM
admet-2861	276	3	]	]	PUNCT
admet-2861	276	4	136.00	136.00	NUM
admet-2861	277	1	[	[	SYM
admet-2861	277	2	30	30	NUM
admet-2861	277	3	]	]	PUNCT
admet-2861	277	4	120.00	120.00	NUM
admet-2861	277	5	[	[	SYM
admet-2861	277	6	41	41	NUM
admet-2861	277	7	]	]	PUNCT
admet-2861	277	8	dose	dose	NOUN
admet-2861	277	9	/	/	SYM
admet-2861	277	10	µg	µg	ADP
admet-2861	277	11	1000	1000	NUM
admet-2861	277	12	892	892	NUM
admet-2861	277	13	3570	3570	NUM
admet-2861	277	14	unbound	unbound	NOUN
admet-2861	277	15	fraction	fraction	NOUN
admet-2861	277	16	in	in	ADP
admet-2861	277	17	plasma	plasma	NOUN
admet-2861	277	18	0.05	0.05	NUM
admet-2861	278	1	[	[	X
admet-2861	278	2	41	41	NUM
admet-2861	278	3	]	]	X
admet-2861	278	4	t1/2c	t1/2c	NOUN
admet-2861	278	5	/	/	SYM
admet-2861	278	6	h	h	NOUN
admet-2861	278	7	0.47	0.47	NUM
admet-2861	279	1	[	[	X
admet-2861	279	2	30	30	NUM
admet-2861	279	3	]	]	PUNCT
admet-2861	279	4	2.42	2.42	NUM
admet-2861	280	1	[	[	X
admet-2861	280	2	30	30	NUM
admet-2861	280	3	]	]	SYM
admet-2861	280	4	4.28	4.28	NUM
admet-2861	281	1	[	[	X
admet-2861	281	2	30	30	NUM
admet-2861	281	3	]	]	X
admet-2861	281	4	k12d	k12d	PROPN
admet-2861	281	5	/	/	SYM
admet-2861	281	6	h-1	h-1	NOUN
admet-2861	281	7	0.741	0.741	NUM
admet-2861	281	8	g	g	PROPN
admet-2861	281	9	1.403	1.403	NUM
admet-2861	281	10	g	g	PROPN
admet-2861	281	11	1.403	1.403	NUM
admet-2861	281	12	g	g	NOUN
admet-2861	281	13	k21e/	k21e/	PROPN
admet-2861	281	14	h-1	h-1	NOUN
admet-2861	281	15	1.530	1.530	NUM
admet-2861	281	16	g	g	NOUN
admet-2861	281	17	1.997	1.997	NUM
admet-2861	281	18	g	g	ADP
admet-2861	281	19	1.997	1.997	NUM
admet-2861	281	20	g	g	NOUN
admet-2861	281	21	acentral	acentral	ADJ
admet-2861	281	22	volume	volume	NOUN
admet-2861	281	23	of	of	ADP
admet-2861	281	24	distribution	distribution	NOUN
admet-2861	281	25	;	;	PUNCT
admet-2861	281	26	bclearance	bclearance	NOUN
admet-2861	281	27	;	;	PUNCT
admet-2861	281	28	chalf	chalf	ADJ
admet-2861	281	29	-	-	PUNCT
admet-2861	281	30	life	life	NOUN
admet-2861	281	31	;	;	PUNCT
admet-2861	281	32	dtransfer	dtransfer	VERB
admet-2861	281	33	rate	rate	NOUN
admet-2861	281	34	constant	constant	ADJ
admet-2861	281	35	from	from	ADP
admet-2861	281	36	the	the	DET
admet-2861	281	37	central	central	ADJ
admet-2861	281	38	compartment	compartment	NOUN
admet-2861	281	39	(	(	PUNCT
admet-2861	281	40	1	1	NUM
admet-2861	281	41	)	)	PUNCT
admet-2861	281	42	to	to	ADP
admet-2861	281	43	the	the	DET
admet-2861	281	44	peripheral	peripheral	ADJ
admet-2861	281	45	compartment	compartment	NOUN
admet-2861	281	46	(	(	PUNCT
admet-2861	281	47	2	2	NUM
admet-2861	281	48	)	)	PUNCT
admet-2861	281	49	;	;	PUNCT
admet-2861	281	50	etransfer	etransfer	NOUN
admet-2861	281	51	rate	rate	NOUN
admet-2861	281	52	constant	constant	ADJ
admet-2861	281	53	from	from	ADP
admet-2861	281	54	the	the	DET
admet-2861	281	55	peripheral	peripheral	ADJ
admet-2861	281	56	compartment	compartment	NOUN
admet-2861	281	57	(	(	PUNCT
admet-2861	281	58	2	2	NUM
admet-2861	281	59	)	)	PUNCT
admet-2861	281	60	to	to	ADP
admet-2861	281	61	the	the	DET
admet-2861	281	62	central	central	ADJ
admet-2861	281	63	compartment	compartment	NOUN
admet-2861	281	64	(	(	PUNCT
admet-2861	281	65	1	1	NUM
admet-2861	281	66	)	)	PUNCT
admet-2861	281	67	;	;	PUNCT
admet-2861	281	68	foptimized	foptimize	VERB
admet-2861	281	69	values	value	NOUN
admet-2861	281	70	;	;	PUNCT
admet-2861	281	71	gvalues	gvalue	NOUN
admet-2861	281	72	predicted	predict	VERB
admet-2861	281	73	by	by	ADP
admet-2861	281	74	gastroplus	gastroplus	ADJ
admet-2861	281	75	™	™	PROPN
admet-2861	281	76	to	to	PART
admet-2861	281	77	validate	validate	VERB
admet-2861	281	78	the	the	DET
admet-2861	281	79	model	model	NOUN
admet-2861	281	80	,	,	PUNCT
admet-2861	281	81	the	the	DET
admet-2861	281	82	generated	generate	VERB
admet-2861	281	83	plasma	plasma	NOUN
admet-2861	281	84	profiles	profile	NOUN
admet-2861	281	85	were	be	AUX
admet-2861	281	86	compared	compare	VERB
admet-2861	281	87	with	with	ADP
admet-2861	281	88	the	the	DET
admet-2861	281	89	equivalent	equivalent	ADJ
admet-2861	281	90	curves	curve	NOUN
admet-2861	281	91	from	from	ADP
admet-2861	281	92	the	the	DET
admet-2861	281	93	in	in	ADP
admet-2861	281	94	vivo	vivo	NOUN
admet-2861	281	95	studies	study	NOUN
admet-2861	281	96	.	.	PUNCT
admet-2861	282	1	to	to	PART
admet-2861	282	2	achieve	achieve	VERB
admet-2861	282	3	a	a	DET
admet-2861	282	4	better	well	ADJ
admet-2861	282	5	correlation	correlation	NOUN
admet-2861	282	6	between	between	ADP
admet-2861	282	7	in	in	ADP
admet-2861	282	8	vivo	vivo	NOUN
admet-2861	282	9	and	and	CCONJ
admet-2861	282	10	in	in	ADP
admet-2861	282	11	silico	silico	NOUN
admet-2861	282	12	cp	cp	PROPN
admet-2861	282	13	-	-	PUNCT
admet-2861	282	14	t	t	NOUN
admet-2861	282	15	curves	curve	NOUN
admet-2861	282	16	,	,	PUNCT
admet-2861	282	17	the	the	DET
admet-2861	282	18	values	value	NOUN
admet-2861	282	19	given	give	VERB
admet-2861	282	20	in	in	ADP
admet-2861	282	21	the	the	DET
admet-2861	282	22	literature	literature	NOUN
admet-2861	282	23	were	be	AUX
admet-2861	282	24	not	not	PART
admet-2861	282	25	necessarily	necessarily	ADV
admet-2861	282	26	used	use	VERB
admet-2861	282	27	;	;	PUNCT
admet-2861	282	28	instead	instead	ADV
admet-2861	282	29	,	,	PUNCT
admet-2861	282	30	the	the	DET
admet-2861	282	31	values	value	NOUN
admet-2861	282	32	were	be	AUX
admet-2861	282	33	optimized	optimize	VERB
admet-2861	282	34	within	within	ADP
admet-2861	282	35	the	the	DET
admet-2861	282	36	range	range	NOUN
admet-2861	282	37	of	of	ADP
admet-2861	282	38	reported	report	VERB
admet-2861	282	39	results	result	NOUN
admet-2861	282	40	.	.	PUNCT
admet-2861	283	1	figures	figure	NOUN
admet-2861	283	2	10a	10a	NOUN
admet-2861	283	3	,	,	PUNCT
admet-2861	283	4	10b	10b	NOUN
admet-2861	283	5	and	and	CCONJ
admet-2861	283	6	10c	10c	NOUN
admet-2861	283	7	show	show	VERB
admet-2861	283	8	a	a	DET
admet-2861	283	9	comparison	comparison	NOUN
admet-2861	283	10	of	of	ADP
admet-2861	283	11	the	the	DET
admet-2861	283	12	generated	generate	VERB
admet-2861	283	13	in	in	ADP
admet-2861	283	14	silico	silico	NOUN
admet-2861	283	15	and	and	CCONJ
admet-2861	283	16	in	in	ADP
admet-2861	283	17	vivo	vivo	ADJ
admet-2861	283	18	data	datum	NOUN
admet-2861	283	19	for	for	ADP
admet-2861	283	20	intravenously	intravenously	ADV
admet-2861	283	21	(	(	PUNCT
admet-2861	283	22	i.v	i.v	X
admet-2861	283	23	.	.	PUNCT
admet-2861	283	24	)	)	PUNCT
admet-2861	283	25	and	and	CCONJ
admet-2861	283	26	orally	orally	ADV
admet-2861	283	27	administered	administer	VERB
admet-2861	283	28	(	(	PUNCT
admet-2861	283	29	p.o	p.o	PROPN
admet-2861	283	30	.	.	PROPN
admet-2861	283	31	)	)	PUNCT
admet-2861	283	32	bdp	bdp	PROPN
admet-2861	283	33	and	and	CCONJ
admet-2861	283	34	its	its	PRON
admet-2861	283	35	main	main	ADJ
admet-2861	283	36	active	active	ADJ
admet-2861	283	37	metabolite	metabolite	NOUN
admet-2861	283	38	,	,	PUNCT
admet-2861	283	39	bmp-17	bmp-17	X
admet-2861	283	40	.	.	PUNCT
admet-2861	284	1	the	the	DET
admet-2861	284	2	correlation	correlation	NOUN
admet-2861	284	3	between	between	ADP
admet-2861	284	4	the	the	DET
admet-2861	284	5	in	in	ADP
admet-2861	284	6	silico	silico	NOUN
admet-2861	284	7	and	and	CCONJ
admet-2861	284	8	in	in	ADP
admet-2861	284	9	vivo	vivo	ADJ
admet-2861	284	10	data	datum	NOUN
admet-2861	284	11	is	be	AUX
admet-2861	284	12	given	give	VERB
admet-2861	284	13	in	in	ADP
admet-2861	284	14	table	table	NOUN
admet-2861	284	15	10	10	NUM
admet-2861	284	16	.	.	PUNCT
admet-2861	285	1	a	a	DET
admet-2861	285	2	relatively	relatively	ADV
admet-2861	285	3	low	low	ADJ
admet-2861	285	4	correlation	correlation	NOUN
admet-2861	285	5	(	(	PUNCT
admet-2861	285	6	0.893	0.893	NUM
admet-2861	285	7	)	)	PUNCT
admet-2861	285	8	was	be	AUX
admet-2861	285	9	obtained	obtain	VERB
admet-2861	285	10	for	for	ADP
admet-2861	285	11	the	the	DET
admet-2861	285	12	predicted	predict	VERB
admet-2861	285	13	cp	cp	PROPN
admet-2861	285	14	-	-	PROPN
admet-2861	285	15	t	t	PROPN
admet-2861	285	16	profile	profile	NOUN
admet-2861	285	17	after	after	ADP
admet-2861	285	18	oral	oral	ADJ
admet-2861	285	19	administration	administration	NOUN
admet-2861	285	20	of	of	ADP
admet-2861	285	21	bdp	bdp	PROPN
admet-2861	285	22	(	(	PUNCT
admet-2861	285	23	figure	figure	NOUN
admet-2861	285	24	10c	10c	NOUN
admet-2861	285	25	and	and	CCONJ
admet-2861	285	26	table	table	NOUN
admet-2861	285	27	10	10	NUM
admet-2861	285	28	)	)	PUNCT
admet-2861	285	29	.	.	PUNCT
admet-2861	286	1	in	in	ADP
admet-2861	286	2	the	the	DET
admet-2861	286	3	in	in	ADJ
admet-2861	286	4	vivo	vivo	NOUN
admet-2861	286	5	study	study	NOUN
admet-2861	286	6	,	,	PUNCT
admet-2861	286	7	following	follow	VERB
admet-2861	286	8	p.o	p.o	PROPN
admet-2861	286	9	.	.	PROPN
admet-2861	286	10	administration	administration	PROPN
admet-2861	286	11	,	,	PUNCT
admet-2861	286	12	bdp	bdp	PROPN
admet-2861	286	13	was	be	AUX
admet-2861	286	14	not	not	PART
admet-2861	286	15	detected	detect	VERB
admet-2861	286	16	in	in	ADP
admet-2861	286	17	the	the	DET
admet-2861	286	18	bloodstream	bloodstream	NOUN
admet-2861	286	19	;	;	PUNCT
admet-2861	286	20	only	only	ADV
admet-2861	286	21	its	its	PRON
admet-2861	286	22	metabolite	metabolite	NOUN
admet-2861	286	23	,	,	PUNCT
admet-2861	286	24	bmp-17	bmp-17	ADV
admet-2861	286	25	,	,	PUNCT
admet-2861	286	26	was	be	AUX
admet-2861	286	27	present	present	ADJ
admet-2861	286	28	.	.	PUNCT
admet-2861	287	1	this	this	PRON
admet-2861	287	2	posed	pose	VERB
admet-2861	287	3	a	a	DET
admet-2861	287	4	challenge	challenge	NOUN
admet-2861	287	5	that	that	PRON
admet-2861	287	6	was	be	AUX
admet-2861	287	7	addressed	address	VERB
admet-2861	287	8	by	by	ADP
admet-2861	287	9	creating	create	VERB
admet-2861	287	10	a	a	DET
admet-2861	287	11	“	"	PUNCT
admet-2861	287	12	hybrid	hybrid	NOUN
admet-2861	287	13	”	"	PUNCT
admet-2861	287	14	model	model	NOUN
admet-2861	287	15	that	that	PRON
admet-2861	287	16	combined	combine	VERB
admet-2861	287	17	the	the	DET
admet-2861	287	18	“	"	PUNCT
admet-2861	287	19	entry	entry	NOUN
admet-2861	287	20	”	"	PUNCT
admet-2861	287	21	parameters	parameter	NOUN
admet-2861	287	22	(	(	PUNCT
admet-2861	287	23	parameters	parameter	NOUN
admet-2861	287	24	related	relate	VERB
admet-2861	287	25	to	to	ADP
admet-2861	287	26	absorption	absorption	NOUN
admet-2861	287	27	)	)	PUNCT
admet-2861	287	28	of	of	ADP
admet-2861	287	29	bdp	bdp	PROPN
admet-2861	287	30	with	with	ADP
admet-2861	287	31	the	the	DET
admet-2861	287	32	“	"	PUNCT
admet-2861	287	33	exit	exit	NOUN
admet-2861	287	34	”	"	PUNCT
admet-2861	287	35	parameters	parameter	NOUN
admet-2861	287	36	(	(	PUNCT
admet-2861	287	37	parameters	parameter	NOUN
admet-2861	287	38	related	relate	VERB
admet-2861	287	39	to	to	ADP
admet-2861	287	40	elimination	elimination	NOUN
admet-2861	287	41	and	and	CCONJ
admet-2861	287	42	distribution	distribution	NOUN
admet-2861	287	43	)	)	PUNCT
admet-2861	287	44	of	of	ADP
admet-2861	287	45	bmp-17	bmp-17	NOUN
admet-2861	287	46	.	.	PUNCT
admet-2861	288	1	this	this	DET
admet-2861	288	2	approach	approach	NOUN
admet-2861	288	3	simulated	simulate	VERB
admet-2861	288	4	the	the	DET
admet-2861	288	5	absorption	absorption	NOUN
admet-2861	288	6	of	of	ADP
admet-2861	288	7	bdp	bdp	PROPN
admet-2861	288	8	,	,	PUNCT
admet-2861	288	9	its	its	PRON
admet-2861	288	10	complete	complete	ADJ
admet-2861	288	11	biotransformation	biotransformation	NOUN
admet-2861	288	12	in	in	ADP
admet-2861	288	13	the	the	DET
admet-2861	288	14	liver	liver	NOUN
admet-2861	288	15	,	,	PUNCT
admet-2861	288	16	and	and	CCONJ
admet-2861	288	17	the	the	DET
admet-2861	288	18	distribution	distribution	NOUN
admet-2861	288	19	and	and	CCONJ
admet-2861	288	20	elimination	elimination	NOUN
admet-2861	288	21	of	of	ADP
admet-2861	288	22	the	the	DET
admet-2861	288	23	metabolite	metabolite	NOUN
admet-2861	288	24	,	,	PUNCT
admet-2861	288	25	bmp-17	bmp-17	ADV
admet-2861	288	26	.	.	PUNCT
admet-2861	289	1	considering	consider	VERB
admet-2861	289	2	that	that	SCONJ
admet-2861	289	3	the	the	DET
admet-2861	289	4	oral	oral	ADJ
admet-2861	289	5	route	route	NOUN
admet-2861	289	6	of	of	ADP
admet-2861	289	7	administration	administration	NOUN
admet-2861	289	8	will	will	AUX
admet-2861	289	9	not	not	PART
admet-2861	289	10	be	be	AUX
admet-2861	289	11	part	part	NOUN
admet-2861	289	12	of	of	ADP
admet-2861	289	13	further	further	ADJ
admet-2861	289	14	testing	testing	NOUN
admet-2861	289	15	and	and	CCONJ
admet-2861	289	16	that	that	SCONJ
admet-2861	289	17	this	this	DET
admet-2861	289	18	aspect	aspect	NOUN
admet-2861	289	19	of	of	ADP
admet-2861	289	20	the	the	DET
admet-2861	289	21	simulation	simulation	NOUN
admet-2861	289	22	served	serve	VERB
admet-2861	289	23	as	as	ADP
admet-2861	289	24	a	a	DET
admet-2861	289	25	form	form	NOUN
admet-2861	289	26	of	of	ADP
admet-2861	289	27	cross	cross	NOUN
admet-2861	289	28	-	-	NOUN
admet-2861	289	29	validation	validation	NOUN
admet-2861	289	30	of	of	ADP
admet-2861	289	31	the	the	DET
admet-2861	289	32	input	input	NOUN
admet-2861	289	33	parameters	parameter	NOUN
admet-2861	289	34	for	for	ADP
admet-2861	289	35	the	the	DET
admet-2861	289	36	i.v	i.v	PROPN
admet-2861	289	37	.	.	PROPN
admet-2861	289	38	model	model	PROPN
admet-2861	289	39	,	,	PUNCT
admet-2861	289	40	a	a	DET
admet-2861	289	41	correlation	correlation	NOUN
admet-2861	289	42	of	of	ADP
admet-2861	289	43	0.893	0.893	NUM
admet-2861	289	44	was	be	AUX
admet-2861	289	45	deemed	deem	VERB
admet-2861	289	46	appropriate	appropriate	ADJ
admet-2861	289	47	.	.	PUNCT
admet-2861	290	1	table	table	NOUN
admet-2861	290	2	10	10	NUM
admet-2861	290	3	.	.	PUNCT
admet-2861	291	1	correlation	correlation	NOUN
admet-2861	291	2	between	between	ADP
admet-2861	291	3	predicted	predict	VERB
admet-2861	291	4	(	(	PUNCT
admet-2861	291	5	in	in	ADP
admet-2861	291	6	silico	silico	NOUN
admet-2861	291	7	)	)	PUNCT
admet-2861	291	8	and	and	CCONJ
admet-2861	291	9	in	in	ADP
admet-2861	291	10	vivo	vivo	ADJ
admet-2861	291	11	cp	cp	PROPN
admet-2861	291	12	-	-	PROPN
admet-2861	291	13	t	t	PROPN
admet-2861	291	14	curves	curve	NOUN
admet-2861	291	15	of	of	ADP
admet-2861	291	16	bdp	bdp	PROPN
admet-2861	291	17	bdp	bdp	PROPN
admet-2861	291	18	i.v	i.v	PROPN
admet-2861	291	19	aplication	aplication	PROPN
admet-2861	291	20	bmp-17	bmp-17	VERB
admet-2861	291	21	after	after	ADP
admet-2861	291	22	i.v	i.v	PROPN
admet-2861	291	23	.	.	PUNCT
admet-2861	291	24	application	application	NOUN
admet-2861	291	25	of	of	ADP
admet-2861	291	26	bdp	bdp	PROPN
admet-2861	291	27	bdp	bdp	PROPN
admet-2861	291	28	/	/	SYM
admet-2861	291	29	bmp-17	bmp-17	CCONJ
admet-2861	291	30	hybrid	hybrid	NOUN
admet-2861	291	31	after	after	ADP
admet-2861	291	32	oral	oral	ADJ
admet-2861	291	33	application	application	NOUN
admet-2861	291	34	bdp	bdp	PROPN
admet-2861	291	35	after	after	ADP
admet-2861	291	36	application	application	NOUN
admet-2861	291	37	of	of	ADP
admet-2861	291	38	the	the	DET
admet-2861	291	39	inhalation	inhalation	NOUN
admet-2861	291	40	product	product	NOUN
admet-2861	291	41	b1	b1	NOUN
admet-2861	291	42	b2	b2	NOUN
admet-2861	291	43	r2	r2	NOUN
admet-2861	291	44	0.821	0.821	NUM
admet-2861	291	45	0.997	0.997	NUM
admet-2861	291	46	0.893	0.893	NUM
admet-2861	291	47	n.a	n.a	PROPN
admet-2861	291	48	.	.	PROPN
admet-2861	292	1	*	*	PROPN
admet-2861	293	1	0.99	0.99	NUM
admet-2861	293	2	*	*	PUNCT
admet-2861	293	3	in	in	ADP
admet-2861	293	4	the	the	DET
admet-2861	293	5	in	in	ADP
admet-2861	293	6	vivo	vivo	ADJ
admet-2861	293	7	cp	cp	PROPN
admet-2861	293	8	-	-	PUNCT
admet-2861	293	9	t	t	PROPN
admet-2861	293	10	curve	curve	NOUN
admet-2861	293	11	,	,	PUNCT
admet-2861	293	12	there	there	PRON
admet-2861	293	13	is	be	VERB
admet-2861	293	14	only	only	ADV
admet-2861	293	15	one	one	NUM
admet-2861	293	16	point	point	NOUN
admet-2861	293	17	with	with	ADP
admet-2861	293	18	a	a	DET
admet-2861	293	19	detectable	detectable	ADJ
admet-2861	293	20	amount	amount	NOUN
admet-2861	293	21	of	of	ADP
admet-2861	293	22	bdp	bdp	PROPN
admet-2861	293	23	in	in	ADP
admet-2861	293	24	plasma	plasma	NOUN
admet-2861	293	25	,	,	PUNCT
admet-2861	293	26	and	and	CCONJ
admet-2861	293	27	no	no	DET
admet-2861	293	28	correlation	correlation	NOUN
admet-2861	293	29	can	can	AUX
admet-2861	293	30	be	be	AUX
admet-2861	293	31	established	establish	VERB
admet-2861	293	32	.	.	PUNCT
admet-2861	294	1	instead	instead	ADV
admet-2861	294	2	,	,	PUNCT
admet-2861	294	3	the	the	DET
admet-2861	294	4	prediction	prediction	NOUN
admet-2861	294	5	error	error	NOUN
admet-2861	294	6	(	(	PUNCT
admet-2861	294	7	pe	pe	INTJ
admet-2861	294	8	)	)	PUNCT
admet-2861	294	9	was	be	AUX
admet-2861	294	10	calculated	calculate	VERB
admet-2861	294	11	for	for	ADP
admet-2861	294	12	the	the	DET
admet-2861	294	13	cp	cp	PROPN
admet-2861	294	14	-	-	PUNCT
admet-2861	294	15	t	t	PROPN
admet-2861	294	16	value	value	NOUN
admet-2861	294	17	at	at	ADP
admet-2861	294	18	that	that	DET
admet-2861	294	19	time	time	NOUN
admet-2861	294	20	point	point	NOUN
admet-2861	294	21	(	(	PUNCT
admet-2861	294	22	pe	pe	NOUN
admet-2861	294	23	=	=	SYM
admet-2861	294	24	0.44	0.44	NUM
admet-2861	294	25	%	%	NOUN
admet-2861	294	26	)	)	PUNCT
admet-2861	294	27	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	294	28	a.	a.	PROPN
admet-2861	294	29	elezović	elezović	PROPN
admet-2861	294	30	et	et	PROPN
admet-2861	294	31	al	al	PROPN
admet-2861	294	32	.	.	PROPN
admet-2861	294	33	admet	admet	PROPN
admet-2861	294	34	&	&	CCONJ
admet-2861	294	35	dmpk	dmpk	PROPN
admet-2861	294	36	13(5	13(5	NUM
admet-2861	294	37	)	)	PUNCT
admet-2861	294	38	(	(	PUNCT
admet-2861	294	39	2025	2025	NUM
admet-2861	294	40	)	)	PUNCT
admet-2861	294	41	2861	2861	NUM
admet-2861	294	42	16	16	NUM
admet-2861	294	43	(	(	PUNCT
admet-2861	294	44	a	a	NOUN
admet-2861	294	45	)	)	PUNCT
admet-2861	294	46	(	(	PUNCT
admet-2861	294	47	b	b	X
admet-2861	294	48	)	)	PUNCT
admet-2861	294	49	(	(	PUNCT
admet-2861	294	50	c	c	X
admet-2861	294	51	)	)	PUNCT
admet-2861	294	52	figure	figure	NOUN
admet-2861	294	53	10	10	NUM
admet-2861	294	54	.	.	PUNCT
admet-2861	295	1	simulated	simulate	VERB
admet-2861	295	2	and	and	CCONJ
admet-2861	295	3	in	in	ADP
admet-2861	295	4	vivo	vivo	ADJ
admet-2861	295	5	concentration	concentration	NOUN
admet-2861	295	6	/	/	SYM
admet-2861	295	7	time	time	NOUN
admet-2861	295	8	curves	curve	NOUN
admet-2861	295	9	for	for	ADP
admet-2861	295	10	a	a	DET
admet-2861	295	11	bdp	bdp	PROPN
admet-2861	295	12	after	after	ADP
admet-2861	295	13	i.v	i.v	PROPN
admet-2861	295	14	.	.	PROPN
admet-2861	295	15	application	application	NOUN
admet-2861	295	16	(	(	PUNCT
admet-2861	295	17	-simulated	-simulate	VERB
admet-2861	295	18	;	;	PUNCT
admet-2861	295	19	δ	δ	PROPN
admet-2861	295	20	in	in	ADP
admet-2861	295	21	vivo	vivo	NOUN
admet-2861	295	22	)	)	PUNCT
admet-2861	295	23	;	;	PUNCT
admet-2861	295	24	b	b	X
admet-2861	295	25	bmp-17	bmp-17	CCONJ
admet-2861	295	26	after	after	ADP
admet-2861	295	27	i.v	i.v	PROPN
admet-2861	295	28	.	.	PROPN
admet-2861	295	29	administration	administration	PROPN
admet-2861	295	30	(	(	PUNCT
admet-2861	295	31	·	·	PUNCT
admet-2861	295	32	·	·	PUNCT
admet-2861	295	33	·	·	PUNCT
admet-2861	295	34	simulated	simulate	VERB
admet-2861	295	35	;	;	PUNCT
admet-2861	295	36	o	o	NOUN
admet-2861	295	37	in	in	ADP
admet-2861	295	38	vivo	vivo	NOUN
admet-2861	295	39	)	)	PUNCT
admet-2861	295	40	;	;	PUNCT
admet-2861	295	41	c	c	PROPN
admet-2861	295	42	bmp-17	bmp-17	X
admet-2861	295	43	after	after	ADP
admet-2861	295	44	oral	oral	ADJ
admet-2861	295	45	administration	administration	NOUN
admet-2861	295	46	of	of	ADP
admet-2861	295	47	bdp	bdp	PROPN
admet-2861	295	48	(	(	PUNCT
admet-2861	295	49	-··simulated	-··simulate	VERB
admet-2861	295	50	;	;	PUNCT
admet-2861	295	51	◊	◊	NUM
admet-2861	295	52	in	in	ADP
admet-2861	295	53	vivo	vivo	NOUN
admet-2861	295	54	)	)	PUNCT
admet-2861	295	55	the	the	DET
admet-2861	295	56	created	create	VERB
admet-2861	295	57	model	model	NOUN
admet-2861	295	58	served	serve	VERB
admet-2861	295	59	as	as	ADP
admet-2861	295	60	the	the	DET
admet-2861	295	61	basis	basis	NOUN
admet-2861	295	62	for	for	ADP
admet-2861	295	63	developing	develop	VERB
admet-2861	295	64	profiles	profile	NOUN
admet-2861	295	65	of	of	ADP
admet-2861	295	66	three	three	NUM
admet-2861	295	67	inhalation	inhalation	NOUN
admet-2861	295	68	products	product	NOUN
admet-2861	295	69	containing	contain	VERB
admet-2861	295	70	bdp	bdp	PROPN
admet-2861	295	71	.	.	PUNCT
admet-2861	296	1	the	the	DET
admet-2861	296	2	model	model	NOUN
admet-2861	296	3	was	be	AUX
admet-2861	296	4	supplemented	supplement	VERB
admet-2861	296	5	with	with	ADP
admet-2861	296	6	biopharmaceutical	biopharmaceutical	ADJ
admet-2861	296	7	characteristics	characteristic	NOUN
admet-2861	296	8	of	of	ADP
admet-2861	296	9	each	each	DET
admet-2861	296	10	individual	individual	ADJ
admet-2861	296	11	preparation	preparation	NOUN
admet-2861	296	12	.	.	PUNCT
admet-2861	297	1	these	these	DET
admet-2861	297	2	characteristics	characteristic	NOUN
admet-2861	297	3	are	be	AUX
admet-2861	297	4	based	base	VERB
admet-2861	297	5	on	on	ADP
admet-2861	297	6	the	the	DET
admet-2861	297	7	size	size	NOUN
admet-2861	297	8	distribution	distribution	NOUN
admet-2861	297	9	of	of	ADP
admet-2861	297	10	aerosol	aerosol	NOUN
admet-2861	297	11	particles	particle	NOUN
admet-2861	297	12	,	,	PUNCT
admet-2861	297	13	which	which	PRON
admet-2861	297	14	is	be	AUX
admet-2861	297	15	assumed	assume	VERB
admet-2861	297	16	to	to	PART
admet-2861	297	17	provide	provide	VERB
admet-2861	297	18	insight	insight	NOUN
admet-2861	297	19	into	into	ADP
admet-2861	297	20	the	the	DET
admet-2861	297	21	localization	localization	NOUN
admet-2861	297	22	of	of	ADP
admet-2861	297	23	aerosol	aerosol	NOUN
admet-2861	297	24	particle	particle	NOUN
admet-2861	297	25	deposition	deposition	NOUN
admet-2861	297	26	in	in	ADP
admet-2861	297	27	the	the	DET
admet-2861	297	28	respiratory	respiratory	ADJ
admet-2861	297	29	tract	tract	NOUN
admet-2861	297	30	and	and	CCONJ
admet-2861	297	31	,	,	PUNCT
admet-2861	297	32	consequently	consequently	ADV
admet-2861	297	33	,	,	PUNCT
admet-2861	297	34	the	the	DET
admet-2861	297	35	efficacy	efficacy	NOUN
admet-2861	297	36	of	of	ADP
admet-2861	297	37	the	the	DET
admet-2861	297	38	drug	drug	NOUN
admet-2861	297	39	.	.	PUNCT
admet-2861	298	1	the	the	DET
admet-2861	298	2	aerodynamic	aerodynamic	ADJ
admet-2861	298	3	distribution	distribution	NOUN
admet-2861	298	4	of	of	ADP
admet-2861	298	5	bdp	bdp	PROPN
admet-2861	298	6	particles	particle	NOUN
admet-2861	298	7	was	be	AUX
admet-2861	298	8	obtained	obtain	VERB
admet-2861	298	9	using	use	VERB
admet-2861	298	10	the	the	DET
admet-2861	298	11	next	next	ADJ
admet-2861	298	12	generation	generation	NOUN
admet-2861	298	13	impactor	impactor	NOUN
admet-2861	298	14	(	(	PUNCT
admet-2861	298	15	ngi	ngi	PROPN
admet-2861	298	16	)	)	PUNCT
admet-2861	298	17	(	(	PUNCT
admet-2861	298	18	copley	copley	NOUN
admet-2861	298	19	scientific	scientific	PROPN
admet-2861	298	20	,	,	PUNCT
admet-2861	298	21	nottingham	nottingham	PROPN
admet-2861	298	22	,	,	PUNCT
admet-2861	298	23	uk	uk	PROPN
admet-2861	298	24	)	)	PUNCT
admet-2861	298	25	according	accord	VERB
admet-2861	298	26	to	to	ADP
admet-2861	298	27	the	the	DET
admet-2861	298	28	procedure	procedure	NOUN
admet-2861	298	29	outlined	outline	VERB
admet-2861	298	30	in	in	ADP
admet-2861	298	31	the	the	DET
admet-2861	298	32	ph	ph	PROPN
admet-2861	298	33	.	.	PROPN
admet-2861	298	34	eur	eur	PROPN
admet-2861	298	35	.	.	PUNCT
admet-2861	298	36	monograph	monograph	NOUN
admet-2861	298	37	on	on	ADP
admet-2861	298	38	aerodynamic	aerodynamic	ADJ
admet-2861	298	39	distribution	distribution	NOUN
admet-2861	298	40	of	of	ADP
admet-2861	298	41	fine	fine	ADJ
admet-2861	298	42	particles	particle	NOUN
admet-2861	298	43	[	[	X
admet-2861	298	44	2	2	NUM
admet-2861	298	45	]	]	PUNCT
admet-2861	298	46	.	.	PUNCT
admet-2861	299	1	from	from	ADP
admet-2861	299	2	these	these	DET
admet-2861	299	3	data	datum	NOUN
admet-2861	299	4	,	,	PUNCT
admet-2861	299	5	the	the	DET
admet-2861	299	6	pharmaceutical	pharmaceutical	NOUN
admet-2861	299	7	-	-	PUNCT
admet-2861	299	8	technological	technological	ADJ
admet-2861	299	9	parameters	parameter	NOUN
admet-2861	299	10	for	for	ADP
admet-2861	299	11	the	the	DET
admet-2861	299	12	tested	test	VERB
admet-2861	299	13	admet	admet	PROPN
admet-2861	299	14	&	&	CCONJ
admet-2861	299	15	dmpk	dmpk	PROPN
admet-2861	299	16	13	13	NUM
admet-2861	299	17	(	(	PUNCT
admet-2861	299	18	)	)	PUNCT
admet-2861	299	19	(	(	PUNCT
admet-2861	299	20	2025	2025	NUM
admet-2861	299	21	)	)	PUNCT
admet-2861	299	22	2861	2861	NUM
admet-2861	299	23	development	development	NOUN
admet-2861	299	24	of	of	ADP
admet-2861	299	25	a	a	DET
admet-2861	299	26	biorelevant	biorelevant	ADJ
admet-2861	299	27	dissolution	dissolution	NOUN
admet-2861	299	28	method	method	NOUN
admet-2861	299	29	for	for	ADP
admet-2861	299	30	inhalation	inhalation	NOUN
admet-2861	299	31	products	product	NOUN
admet-2861	299	32	doi	doi	NOUN
admet-2861	299	33	:	:	PUNCT
admet-2861	299	34	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	299	35	17	17	NUM
admet-2861	299	36	formulations	formulation	NOUN
admet-2861	299	37	were	be	AUX
admet-2861	299	38	calculated	calculate	VERB
admet-2861	299	39	using	use	VERB
admet-2861	299	40	the	the	DET
admet-2861	299	41	citdas	citda	NOUN
admet-2861	299	42	™	™	ADJ
admet-2861	299	43	program	program	NOUN
admet-2861	299	44	,	,	PUNCT
admet-2861	299	45	including	include	VERB
admet-2861	299	46	mmad	mmad	NOUN
admet-2861	299	47	and	and	CCONJ
admet-2861	299	48	gsd	gsd	NOUN
admet-2861	299	49	,	,	PUNCT
admet-2861	299	50	as	as	ADV
admet-2861	299	51	well	well	ADV
admet-2861	299	52	as	as	ADP
admet-2861	299	53	the	the	DET
admet-2861	299	54	distribution	distribution	NOUN
admet-2861	299	55	of	of	ADP
admet-2861	299	56	the	the	DET
admet-2861	299	57	active	active	ADJ
admet-2861	299	58	substance	substance	NOUN
admet-2861	299	59	in	in	ADP
admet-2861	299	60	the	the	DET
admet-2861	299	61	respiratory	respiratory	ADJ
admet-2861	299	62	system	system	NOUN
admet-2861	299	63	.	.	PUNCT
admet-2861	300	1	distribution	distribution	NOUN
admet-2861	300	2	of	of	ADP
admet-2861	300	3	bdp	bdp	PROPN
admet-2861	300	4	particles	particle	NOUN
admet-2861	300	5	in	in	ADP
admet-2861	300	6	the	the	DET
admet-2861	300	7	respiratory	respiratory	ADJ
admet-2861	300	8	tract	tract	NOUN
admet-2861	300	9	was	be	AUX
admet-2861	300	10	calculated	calculate	VERB
admet-2861	300	11	using	use	VERB
admet-2861	300	12	a	a	DET
admet-2861	300	13	procedure	procedure	NOUN
admet-2861	300	14	described	describe	VERB
admet-2861	300	15	elsewhere	elsewhere	ADV
admet-2861	300	16	[	[	X
admet-2861	300	17	31	31	NUM
admet-2861	300	18	]	]	PUNCT
admet-2861	300	19	.	.	PUNCT
admet-2861	301	1	predicted	predict	VERB
admet-2861	301	2	cp	cp	PROPN
admet-2861	301	3	-	-	PROPN
admet-2861	301	4	t	t	NOUN
admet-2861	301	5	curves	curve	NOUN
admet-2861	301	6	are	be	AUX
admet-2861	301	7	presented	present	VERB
admet-2861	301	8	in	in	ADP
admet-2861	301	9	figure	figure	NOUN
admet-2861	301	10	11	11	NUM
admet-2861	301	11	.	.	PUNCT
admet-2861	302	1	(	(	PUNCT
admet-2861	302	2	a	a	X
admet-2861	302	3	)	)	PUNCT
admet-2861	302	4	(	(	PUNCT
admet-2861	302	5	b	b	X
admet-2861	302	6	)	)	PUNCT
admet-2861	302	7	(	(	PUNCT
admet-2861	302	8	c	c	X
admet-2861	302	9	)	)	PUNCT
admet-2861	302	10	figure	figure	NOUN
admet-2861	302	11	11	11	NUM
admet-2861	302	12	.	.	PUNCT
admet-2861	303	1	simulated	simulate	VERB
admet-2861	303	2	and	and	CCONJ
admet-2861	303	3	in	in	ADP
admet-2861	303	4	vivo	vivo	ADJ
admet-2861	303	5	concentration	concentration	NOUN
admet-2861	303	6	/	/	SYM
admet-2861	303	7	time	time	NOUN
admet-2861	303	8	data	datum	NOUN
admet-2861	303	9	for	for	ADP
admet-2861	303	10	bdp	bdp	PROPN
admet-2861	303	11	after	after	ADP
admet-2861	303	12	administration	administration	NOUN
admet-2861	303	13	of	of	ADP
admet-2861	303	14	inhalation	inhalation	NOUN
admet-2861	303	15	products	product	NOUN
admet-2861	303	16	(	(	PUNCT
admet-2861	303	17	a	a	X
admet-2861	303	18	)	)	PUNCT
admet-2861	303	19	b1	b1	NOUN
admet-2861	303	20	(	(	PUNCT
admet-2861	303	21	·	·	PUNCT
admet-2861	303	22	·	·	PUNCT
admet-2861	303	23	·	·	PUNCT
admet-2861	303	24	simulated	simulate	VERB
admet-2861	303	25	;	;	PUNCT
admet-2861	303	26	o	o	X
admet-2861	303	27	–	–	PUNCT
admet-2861	303	28	in	in	ADP
admet-2861	303	29	vivo	vivo	NOUN
admet-2861	303	30	;	;	PUNCT
admet-2861	303	31	ref	ref	NOUN
admet-2861	303	32	.	.	PUNCT
admet-2861	304	1	32	32	NUM
admet-2861	304	2	)	)	PUNCT
admet-2861	304	3	;	;	PUNCT
admet-2861	304	4	(	(	PUNCT
admet-2861	304	5	b	b	X
admet-2861	304	6	)	)	PUNCT
admet-2861	304	7	b2	b2	NOUN
admet-2861	304	8	(	(	PUNCT
admet-2861	304	9	---simulated	---simulate	VERB
admet-2861	304	10	;	;	PUNCT
admet-2861	304	11	◊	◊	PROPN
admet-2861	304	12	in	in	ADP
admet-2861	304	13	vivo	vivo	NOUN
admet-2861	304	14	;	;	PUNCT
admet-2861	304	15	ref	ref	NOUN
admet-2861	304	16	.	.	PUNCT
admet-2861	304	17	33	33	NUM
admet-2861	304	18	)	)	PUNCT
admet-2861	304	19	;	;	PUNCT
admet-2861	304	20	(	(	PUNCT
admet-2861	304	21	c	c	X
admet-2861	304	22	)	)	PUNCT
admet-2861	304	23	b3	b3	PROPN
admet-2861	304	24	(	(	PUNCT
admet-2861	304	25	-·-·simulated	-·-·simulated	PROPN
admet-2861	304	26	)	)	PUNCT
admet-2861	304	27	all	all	DET
admet-2861	304	28	three	three	NUM
admet-2861	304	29	predicted	predict	VERB
admet-2861	304	30	cp	cp	PROPN
admet-2861	304	31	-	-	PUNCT
admet-2861	304	32	t	t	PROPN
admet-2861	304	33	curves	curve	NOUN
admet-2861	304	34	had	have	VERB
admet-2861	304	35	a	a	DET
admet-2861	304	36	similar	similar	ADJ
admet-2861	304	37	shape	shape	NOUN
admet-2861	304	38	.	.	PUNCT
admet-2861	305	1	the	the	DET
admet-2861	305	2	presence	presence	NOUN
admet-2861	305	3	of	of	ADP
admet-2861	305	4	a	a	DET
admet-2861	305	5	second	second	ADJ
admet-2861	305	6	peak	peak	NOUN
admet-2861	305	7	at	at	ADP
admet-2861	305	8	1	1	NUM
admet-2861	305	9	hour	hour	NOUN
admet-2861	305	10	is	be	AUX
admet-2861	305	11	noticeable	noticeable	ADJ
admet-2861	305	12	.	.	PUNCT
admet-2861	306	1	this	this	DET
admet-2861	306	2	peak	peak	NOUN
admet-2861	306	3	is	be	AUX
admet-2861	306	4	significantly	significantly	ADV
admet-2861	306	5	smaller	small	ADJ
admet-2861	306	6	than	than	ADP
admet-2861	306	7	the	the	DET
admet-2861	306	8	first	first	ADJ
admet-2861	306	9	peak	peak	NOUN
admet-2861	306	10	and	and	CCONJ
admet-2861	306	11	can	can	AUX
admet-2861	306	12	be	be	AUX
admet-2861	306	13	attributed	attribute	VERB
admet-2861	306	14	to	to	ADP
admet-2861	306	15	secondary	secondary	ADJ
admet-2861	306	16	absorption	absorption	NOUN
admet-2861	306	17	through	through	ADP
admet-2861	306	18	the	the	DET
admet-2861	306	19	gastrointestinal	gastrointestinal	ADJ
admet-2861	306	20	tract	tract	NOUN
admet-2861	306	21	,	,	PUNCT
admet-2861	306	22	while	while	SCONJ
admet-2861	306	23	the	the	DET
admet-2861	306	24	first	first	ADJ
admet-2861	306	25	,	,	PUNCT
admet-2861	306	26	main	main	ADJ
admet-2861	306	27	peak	peak	NOUN
admet-2861	306	28	is	be	AUX
admet-2861	306	29	attributed	attribute	VERB
admet-2861	306	30	to	to	ADP
admet-2861	306	31	absorption	absorption	NOUN
admet-2861	306	32	through	through	ADP
admet-2861	306	33	the	the	DET
admet-2861	306	34	lungs	lung	NOUN
admet-2861	306	35	.	.	PUNCT
admet-2861	307	1	although	although	SCONJ
admet-2861	307	2	the	the	DET
admet-2861	307	3	presence	presence	NOUN
admet-2861	307	4	of	of	ADP
admet-2861	307	5	this	this	DET
admet-2861	307	6	peak	peak	NOUN
admet-2861	307	7	contradicts	contradict	VERB
admet-2861	307	8	the	the	DET
admet-2861	307	9	literature	literature	NOUN
admet-2861	307	10	data	datum	NOUN
admet-2861	307	11	on	on	ADP
admet-2861	307	12	the	the	DET
admet-2861	307	13	oral	oral	ADJ
admet-2861	307	14	absorption	absorption	NOUN
admet-2861	307	15	of	of	ADP
admet-2861	307	16	bdp	bdp	PROPN
admet-2861	307	17	(	(	PUNCT
admet-2861	307	18	28	28	NUM
admet-2861	307	19	)	)	PUNCT
admet-2861	307	20	,	,	PUNCT
admet-2861	307	21	it	it	PRON
admet-2861	307	22	was	be	AUX
admet-2861	307	23	detected	detect	VERB
admet-2861	307	24	in	in	ADP
admet-2861	307	25	a	a	DET
admet-2861	307	26	study	study	NOUN
admet-2861	307	27	that	that	PRON
admet-2861	307	28	monitored	monitor	VERB
admet-2861	307	29	the	the	DET
admet-2861	307	30	pharmacokinetics	pharmacokinetic	NOUN
admet-2861	307	31	of	of	ADP
admet-2861	307	32	bdp	bdp	PROPN
admet-2861	307	33	after	after	ADP
admet-2861	307	34	respiratory	respiratory	ADJ
admet-2861	307	35	administration	administration	NOUN
admet-2861	307	36	of	of	ADP
admet-2861	307	37	preparation	preparation	NOUN
admet-2861	307	38	b2	b2	NOUN
admet-2861	308	1	[	[	X
admet-2861	308	2	33	33	NUM
admet-2861	308	3	]	]	PUNCT
admet-2861	308	4	.	.	PUNCT
admet-2861	309	1	these	these	DET
admet-2861	309	2	discrepancies	discrepancy	NOUN
admet-2861	309	3	can	can	AUX
admet-2861	309	4	be	be	AUX
admet-2861	309	5	attributed	attribute	VERB
admet-2861	309	6	to	to	ADP
admet-2861	309	7	differences	difference	NOUN
admet-2861	309	8	in	in	ADP
admet-2861	309	9	the	the	DET
admet-2861	309	10	characteristics	characteristic	NOUN
admet-2861	309	11	of	of	ADP
admet-2861	309	12	the	the	DET
admet-2861	309	13	subjects	subject	NOUN
admet-2861	309	14	(	(	PUNCT
admet-2861	309	15	such	such	ADJ
admet-2861	309	16	as	as	ADP
admet-2861	309	17	gender	gender	NOUN
admet-2861	309	18	,	,	PUNCT
admet-2861	309	19	age	age	NOUN
admet-2861	309	20	,	,	PUNCT
admet-2861	309	21	body	body	NOUN
admet-2861	309	22	weight	weight	NOUN
admet-2861	309	23	,	,	PUNCT
admet-2861	309	24	and	and	CCONJ
admet-2861	309	25	possibly	possibly	ADV
admet-2861	309	26	race	race	NOUN
admet-2861	309	27	)	)	PUNCT
admet-2861	309	28	,	,	PUNCT
admet-2861	309	29	as	as	ADV
admet-2861	309	30	well	well	ADV
admet-2861	309	31	as	as	ADP
admet-2861	309	32	variations	variation	NOUN
admet-2861	309	33	in	in	ADP
admet-2861	309	34	analytical	analytical	ADJ
admet-2861	309	35	procedures	procedure	NOUN
admet-2861	309	36	.	.	PUNCT
admet-2861	310	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	PROPN
admet-2861	310	2	a.	a.	PROPN
admet-2861	310	3	elezović	elezović	PROPN
admet-2861	310	4	et	et	PROPN
admet-2861	310	5	al	al	PROPN
admet-2861	310	6	.	.	PROPN
admet-2861	310	7	admet	admet	PROPN
admet-2861	310	8	&	&	CCONJ
admet-2861	310	9	dmpk	dmpk	PROPN
admet-2861	310	10	13(5	13(5	NUM
admet-2861	310	11	)	)	PUNCT
admet-2861	310	12	(	(	PUNCT
admet-2861	310	13	2025	2025	NUM
admet-2861	310	14	)	)	PUNCT
admet-2861	310	15	2861	2861	NUM
admet-2861	310	16	18	18	NUM
admet-2861	310	17	the	the	DET
admet-2861	310	18	correlation	correlation	NOUN
admet-2861	310	19	between	between	ADP
admet-2861	310	20	the	the	DET
admet-2861	310	21	simulated	simulate	VERB
admet-2861	310	22	and	and	CCONJ
admet-2861	310	23	in	in	ADP
admet-2861	310	24	vivo	vivo	ADJ
admet-2861	310	25	cp	cp	PROPN
admet-2861	310	26	-	-	PROPN
admet-2861	310	27	t	t	NOUN
admet-2861	310	28	curves	curve	NOUN
admet-2861	310	29	of	of	ADP
admet-2861	310	30	bdp	bdp	PROPN
admet-2861	310	31	for	for	ADP
admet-2861	310	32	preparation	preparation	NOUN
admet-2861	310	33	b2	b2	NOUN
admet-2861	310	34	is	be	AUX
admet-2861	310	35	0.99	0.99	NUM
admet-2861	310	36	,	,	PUNCT
admet-2861	310	37	indicating	indicate	VERB
admet-2861	310	38	excellent	excellent	ADJ
admet-2861	310	39	agreement	agreement	NOUN
admet-2861	310	40	.	.	PUNCT
admet-2861	311	1	the	the	DET
admet-2861	311	2	main	main	ADJ
admet-2861	311	3	difference	difference	NOUN
admet-2861	311	4	,	,	PUNCT
admet-2861	311	5	also	also	ADV
admet-2861	311	6	seen	see	VERB
admet-2861	311	7	in	in	ADP
admet-2861	311	8	the	the	DET
admet-2861	311	9	i.v	i.v	PROPN
admet-2861	311	10	.	.	PUNCT
admet-2861	311	11	administration	administration	PROPN
admet-2861	311	12	of	of	ADP
admet-2861	311	13	bdp	bdp	PROPN
admet-2861	311	14	(	(	PUNCT
admet-2861	311	15	figure	figure	NOUN
admet-2861	311	16	10a	10a	NOUN
admet-2861	311	17	)	)	PUNCT
admet-2861	311	18	occurs	occur	VERB
admet-2861	311	19	in	in	ADP
admet-2861	311	20	the	the	DET
admet-2861	311	21	first	first	ADJ
admet-2861	311	22	2	2	NUM
admet-2861	311	23	data	datum	NOUN
admet-2861	311	24	points	point	NOUN
admet-2861	311	25	,	,	PUNCT
admet-2861	311	26	attributed	attribute	VERB
admet-2861	311	27	to	to	ADP
admet-2861	311	28	the	the	DET
admet-2861	311	29	lack	lack	NOUN
admet-2861	311	30	of	of	ADP
admet-2861	311	31	initial	initial	ADJ
admet-2861	311	32	sampling	sampling	NOUN
admet-2861	311	33	points	point	NOUN
admet-2861	311	34	,	,	PUNCT
admet-2861	311	35	which	which	PRON
admet-2861	311	36	affects	affect	VERB
admet-2861	311	37	cmax	cmax	NOUN
admet-2861	311	38	,	,	PUNCT
admet-2861	311	39	tmax	tmax	ADV
admet-2861	311	40	,	,	PUNCT
admet-2861	311	41	and	and	CCONJ
admet-2861	311	42	auc	auc	NOUN
admet-2861	311	43	values	value	NOUN
admet-2861	311	44	.	.	PUNCT
admet-2861	312	1	the	the	DET
admet-2861	312	2	correlation	correlation	NOUN
admet-2861	312	3	for	for	ADP
admet-2861	312	4	preparation	preparation	NOUN
admet-2861	312	5	b1	b1	NOUN
admet-2861	312	6	could	could	AUX
admet-2861	312	7	n't	not	PART
admet-2861	312	8	be	be	AUX
admet-2861	312	9	calculated	calculate	VERB
admet-2861	312	10	due	due	ADP
admet-2861	312	11	to	to	ADP
admet-2861	312	12	the	the	DET
admet-2861	312	13	presence	presence	NOUN
admet-2861	312	14	of	of	ADP
admet-2861	312	15	only	only	ADV
admet-2861	312	16	one	one	NUM
admet-2861	312	17	measurable	measurable	ADJ
admet-2861	312	18	bdp	bdp	PROPN
admet-2861	312	19	concentration	concentration	NOUN
admet-2861	312	20	point	point	NOUN
admet-2861	312	21	after	after	ADP
admet-2861	312	22	respiratory	respiratory	ADJ
admet-2861	312	23	administration	administration	NOUN
admet-2861	312	24	.	.	PUNCT
admet-2861	313	1	additionally	additionally	ADV
admet-2861	313	2	,	,	PUNCT
admet-2861	313	3	the	the	DET
admet-2861	313	4	first	first	ADJ
admet-2861	313	5	sampling	sampling	NOUN
admet-2861	313	6	was	be	AUX
admet-2861	313	7	taken	take	VERB
admet-2861	313	8	30	30	NUM
admet-2861	313	9	minutes	minute	NOUN
admet-2861	313	10	post	post	NOUN
admet-2861	313	11	-	-	NOUN
admet-2861	313	12	administration	administration	NOUN
admet-2861	313	13	,	,	PUNCT
admet-2861	313	14	missing	miss	VERB
admet-2861	313	15	the	the	DET
admet-2861	313	16	initial	initial	ADJ
admet-2861	313	17	peak	peak	NOUN
admet-2861	313	18	of	of	ADP
admet-2861	313	19	cmax	cmax	NOUN
admet-2861	313	20	,	,	PUNCT
admet-2861	313	21	which	which	PRON
admet-2861	313	22	occurs	occur	VERB
admet-2861	313	23	within	within	ADP
admet-2861	313	24	the	the	DET
admet-2861	313	25	first	first	ADJ
admet-2861	313	26	4	4	NUM
admet-2861	313	27	minutes	minute	NOUN
admet-2861	313	28	.	.	PUNCT
admet-2861	314	1	this	this	PRON
admet-2861	314	2	resulted	result	VERB
admet-2861	314	3	in	in	ADP
admet-2861	314	4	a	a	DET
admet-2861	314	5	large	large	ADJ
admet-2861	314	6	portion	portion	NOUN
admet-2861	314	7	of	of	ADP
admet-2861	314	8	the	the	DET
admet-2861	314	9	area	area	NOUN
admet-2861	314	10	under	under	ADP
admet-2861	314	11	the	the	DET
admet-2861	314	12	curve	curve	NOUN
admet-2861	314	13	going	going	AUX
admet-2861	314	14	undetected	undetecte	VERB
admet-2861	314	15	,	,	PUNCT
admet-2861	314	16	despite	despite	SCONJ
admet-2861	314	17	the	the	DET
admet-2861	314	18	ppe	ppe	NOUN
admet-2861	314	19	for	for	ADP
admet-2861	314	20	this	this	DET
admet-2861	314	21	point	point	NOUN
admet-2861	314	22	being	be	AUX
admet-2861	314	23	low	low	ADJ
admet-2861	314	24	at	at	ADP
admet-2861	314	25	0.44	0.44	NUM
admet-2861	314	26	%	%	NOUN
admet-2861	314	27	.	.	PUNCT
admet-2861	315	1	due	due	ADP
admet-2861	315	2	to	to	ADP
admet-2861	315	3	insufficient	insufficient	ADJ
admet-2861	315	4	in	in	ADP
admet-2861	315	5	vivo	vivo	ADJ
admet-2861	315	6	data	datum	NOUN
admet-2861	315	7	for	for	ADP
admet-2861	315	8	preparation	preparation	NOUN
admet-2861	315	9	b3	b3	PROPN
admet-2861	315	10	,	,	PUNCT
admet-2861	315	11	a	a	DET
admet-2861	315	12	comparison	comparison	NOUN
admet-2861	315	13	with	with	ADP
admet-2861	315	14	the	the	DET
admet-2861	315	15	in	in	ADJ
admet-2861	315	16	silico	silico	NOUN
admet-2861	315	17	predicted	predict	VERB
admet-2861	315	18	cp	cp	PROPN
admet-2861	315	19	-	-	PUNCT
admet-2861	315	20	t	t	PROPN
admet-2861	315	21	curve	curve	NOUN
admet-2861	315	22	was	be	AUX
admet-2861	315	23	not	not	PART
admet-2861	315	24	possible	possible	ADJ
admet-2861	315	25	.	.	PUNCT
admet-2861	316	1	the	the	DET
admet-2861	316	2	obtained	obtain	VERB
admet-2861	316	3	curves	curve	NOUN
admet-2861	316	4	of	of	ADP
admet-2861	316	5	the	the	DET
admet-2861	316	6	dissolution	dissolution	ADJ
admet-2861	316	7	profiles	profile	NOUN
admet-2861	316	8	of	of	ADP
admet-2861	316	9	bdp	bdp	PROPN
admet-2861	316	10	(	(	PUNCT
admet-2861	316	11	figure	figure	NOUN
admet-2861	316	12	9	9	NUM
admet-2861	316	13	)	)	PUNCT
admet-2861	316	14	do	do	AUX
admet-2861	316	15	not	not	PART
admet-2861	316	16	reach	reach	VERB
admet-2861	316	17	a	a	DET
admet-2861	316	18	plateau	plateau	NOUN
admet-2861	316	19	with	with	ADP
admet-2861	316	20	maximum	maximum	ADJ
admet-2861	316	21	release	release	NOUN
admet-2861	316	22	during	during	ADP
admet-2861	316	23	the	the	DET
admet-2861	316	24	experiment	experiment	NOUN
admet-2861	316	25	.	.	PUNCT
admet-2861	317	1	the	the	DET
admet-2861	317	2	primary	primary	ADJ
admet-2861	317	3	parameter	parameter	NOUN
admet-2861	317	4	that	that	PRON
admet-2861	317	5	distinguishes	distinguish	VERB
admet-2861	317	6	them	they	PRON
admet-2861	317	7	is	be	AUX
admet-2861	317	8	their	their	PRON
admet-2861	317	9	slope	slope	NOUN
admet-2861	317	10	.	.	PUNCT
admet-2861	318	1	the	the	DET
admet-2861	318	2	slopes	slope	NOUN
admet-2861	318	3	of	of	ADP
admet-2861	318	4	the	the	DET
admet-2861	318	5	release	release	NOUN
admet-2861	318	6	curves	curve	NOUN
admet-2861	318	7	were	be	AUX
admet-2861	318	8	compared	compare	VERB
admet-2861	318	9	with	with	ADP
admet-2861	318	10	the	the	DET
admet-2861	318	11	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	318	12	parameters	parameter	NOUN
admet-2861	318	13	obtained	obtain	VERB
admet-2861	318	14	from	from	ADP
admet-2861	318	15	the	the	DET
admet-2861	318	16	developed	develop	VERB
admet-2861	318	17	in	in	ADP
admet-2861	318	18	silico	silico	NOUN
admet-2861	318	19	models	model	NOUN
admet-2861	318	20	(	(	PUNCT
admet-2861	318	21	table	table	NOUN
admet-2861	318	22	11	11	NUM
admet-2861	318	23	)	)	PUNCT
admet-2861	318	24	.	.	PUNCT
admet-2861	319	1	table	table	NOUN
admet-2861	319	2	11	11	NUM
admet-2861	319	3	.	.	PUNCT
admet-2861	320	1	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	320	2	parameters	parameter	NOUN
admet-2861	320	3	obtained	obtain	VERB
admet-2861	320	4	from	from	ADP
admet-2861	320	5	the	the	DET
admet-2861	320	6	developed	develop	VERB
admet-2861	320	7	in	in	ADP
admet-2861	320	8	silico	silico	NOUN
admet-2861	320	9	models	model	NOUN
admet-2861	320	10	b1	b1	NOUN
admet-2861	320	11	b2	b2	NOUN
admet-2861	320	12	b3	b3	PROPN
admet-2861	320	13	ka	ka	PROPN
admet-2861	320	14	a	a	PRON
admet-2861	320	15	/	/	SYM
admet-2861	320	16	h-1	h-1	NOUN
admet-2861	320	17	44.01	44.01	NUM
admet-2861	320	18	38.43	38.43	NUM
admet-2861	320	19	37.22	37.22	NUM
admet-2861	320	20	k10	k10	PROPN
admet-2861	320	21	b	b	PROPN
admet-2861	320	22	/	/	SYM
admet-2861	320	23	h-1	h-1	PROPN
admet-2861	320	24	6.79×10	6.79×10	PROPN
admet-2861	320	25	-	-	PUNCT
admet-2861	320	26	3	3	NUM
admet-2861	320	27	6.18×10	6.18×10	NUM
admet-2861	320	28	-	-	SYM
admet-2861	320	29	3	3	NUM
admet-2861	320	30	2.53×10	2.53×10	NUM
admet-2861	320	31	-	-	SYM
admet-2861	320	32	3	3	NUM
admet-2861	320	33	cmax	cmax	NOUN
admet-2861	320	34	c	c	PROPN
admet-2861	320	35	/	/	SYM
admet-2861	320	36	ng	ng	PROPN
admet-2861	320	37	ml-1	ml-1	PRON
admet-2861	321	1	(	(	PUNCT
admet-2861	321	2	mg	mg	PROPN
admet-2861	321	3	of	of	ADP
admet-2861	321	4	dose)-1	dose)-1	PROPN
admet-2861	321	5	12.00	12.00	NUM
admet-2861	321	6	9.45	9.45	NUM
admet-2861	321	7	6.66	6.66	NUM
admet-2861	321	8	tmax	tmax	ADP
admet-2861	321	9	d	d	PROPN
admet-2861	321	10	/	/	SYM
admet-2861	321	11	h	h	NOUN
admet-2861	321	12	0.04	0.04	NUM
admet-2861	321	13	0.04	0.04	NUM
admet-2861	321	14	0.04	0.04	NUM
admet-2861	321	15	t1/2	t1/2	NOUN
admet-2861	321	16	/	/	SYM
admet-2861	321	17	h	h	NOUN
admet-2861	321	18	2.42×104	2.42×104	NUM
admet-2861	321	19	1.77×104	1.77×104	PROPN
admet-2861	321	20	2.77×104	2.77×104	NUM
admet-2861	321	21	slope	slope	NOUN
admet-2861	321	22	of	of	ADP
admet-2861	321	23	dissolution	dissolution	NOUN
admet-2861	321	24	curves	curve	NOUN
admet-2861	321	25	,	,	PUNCT
admet-2861	321	26	%	%	NOUN
admet-2861	321	27	min-1	min-1	NUM
admet-2861	321	28	0.204	0.204	NUM
admet-2861	321	29	0.230	0.230	NUM
admet-2861	321	30	0.303	0.303	NUM
admet-2861	321	31	aabsorption	aabsorption	NOUN
admet-2861	321	32	constant	constant	ADJ
admet-2861	321	33	;	;	PUNCT
admet-2861	321	34	belimination	belimination	NOUN
admet-2861	321	35	constant	constant	ADJ
admet-2861	321	36	;	;	PUNCT
admet-2861	321	37	cmaximum	cmaximum	ADJ
admet-2861	321	38	concentration	concentration	NOUN
admet-2861	321	39	in	in	ADP
admet-2861	321	40	plasma	plasma	NOUN
admet-2861	321	41	;	;	PUNCT
admet-2861	321	42	dtime	dtime	NOUN
admet-2861	321	43	in	in	ADP
admet-2861	321	44	which	which	PRON
admet-2861	321	45	cmax	cmax	NOUN
admet-2861	321	46	was	be	AUX
admet-2861	321	47	attained	attain	VERB
admet-2861	321	48	;	;	PUNCT
admet-2861	321	49	a	a	DET
admet-2861	321	50	statistical	statistical	ADJ
admet-2861	321	51	correlation	correlation	NOUN
admet-2861	321	52	parameter	parameter	NOUN
admet-2861	321	53	(	(	PUNCT
admet-2861	321	54	determination	determination	NOUN
admet-2861	321	55	coefficient	coefficient	NOUN
admet-2861	321	56	,	,	PUNCT
admet-2861	321	57	r2	r2	PROPN
admet-2861	321	58	)	)	PUNCT
admet-2861	321	59	between	between	ADP
admet-2861	321	60	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	321	61	parameters	parameter	NOUN
admet-2861	321	62	and	and	CCONJ
admet-2861	321	63	the	the	DET
admet-2861	321	64	slope	slope	NOUN
admet-2861	321	65	of	of	ADP
admet-2861	321	66	dissolution	dissolution	NOUN
admet-2861	321	67	curves	curve	NOUN
admet-2861	321	68	(	(	PUNCT
admet-2861	321	69	table	table	NOUN
admet-2861	321	70	11	11	NUM
admet-2861	321	71	)	)	PUNCT
admet-2861	321	72	was	be	AUX
admet-2861	321	73	determined	determine	VERB
admet-2861	321	74	by	by	ADP
admet-2861	321	75	linear	linear	ADJ
admet-2861	321	76	regression	regression	NOUN
admet-2861	321	77	analysis	analysis	NOUN
admet-2861	321	78	.	.	PUNCT
admet-2861	322	1	the	the	DET
admet-2861	322	2	results	result	NOUN
admet-2861	322	3	of	of	ADP
admet-2861	322	4	the	the	DET
admet-2861	322	5	obtained	obtain	VERB
admet-2861	322	6	correlations	correlation	NOUN
admet-2861	322	7	are	be	AUX
admet-2861	322	8	presented	present	VERB
admet-2861	322	9	in	in	ADP
admet-2861	322	10	table	table	NOUN
admet-2861	322	11	12	12	NUM
admet-2861	322	12	.	.	PUNCT
admet-2861	322	13	table	table	NOUN
admet-2861	322	14	12	12	NUM
admet-2861	322	15	.	.	PUNCT
admet-2861	323	1	correlation	correlation	NOUN
admet-2861	323	2	between	between	ADP
admet-2861	323	3	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	323	4	parameters	parameter	NOUN
admet-2861	323	5	obtained	obtain	VERB
admet-2861	323	6	by	by	ADP
admet-2861	323	7	the	the	DET
admet-2861	323	8	in	in	ADP
admet-2861	323	9	silico	silico	NOUN
admet-2861	323	10	method	method	NOUN
admet-2861	323	11	and	and	CCONJ
admet-2861	323	12	the	the	DET
admet-2861	323	13	slope	slope	NOUN
admet-2861	323	14	of	of	ADP
admet-2861	323	15	the	the	DET
admet-2861	323	16	dissolution	dissolution	NOUN
admet-2861	323	17	curve	curve	NOUN
admet-2861	323	18	of	of	ADP
admet-2861	323	19	inhalation	inhalation	NOUN
admet-2861	323	20	products	product	NOUN
admet-2861	323	21	containing	contain	VERB
admet-2861	323	22	bdp	bdp	PROPN
admet-2861	323	23	.	.	PUNCT
admet-2861	324	1	r2	r2	PROPN
admet-2861	324	2	ka	ka	PROPN
admet-2861	324	3	/	/	SYM
admet-2861	324	4	h-1	h-1	PROPN
admet-2861	324	5	0.6567	0.6567	NUM
admet-2861	324	6	k10	k10	PROPN
admet-2861	324	7	/	/	SYM
admet-2861	324	8	h-1	h-1	NOUN
admet-2861	324	9	0.9855	0.9855	NUM
admet-2861	324	10	cmax	cmax	NOUN
admet-2861	324	11	µg	µg	ADP
admet-2861	324	12	ml-1	ml-1	X
admet-2861	325	1	(	(	PUNCT
admet-2861	325	2	mg	mg	PROPN
admet-2861	325	3	of	of	ADP
admet-2861	325	4	dose)-1	dose)-1	NOUN
admet-2861	325	5	0.9415	0.9415	NUM
admet-2861	325	6	t1/2	t1/2	NOUN
admet-2861	325	7	/	/	SYM
admet-2861	325	8	h-1	h-1	NOUN
admet-2861	325	9	0.3398	0.3398	NUM
admet-2861	326	1	a	a	DET
admet-2861	326	2	good	good	ADJ
admet-2861	326	3	correlation	correlation	NOUN
admet-2861	326	4	between	between	ADP
admet-2861	326	5	the	the	DET
admet-2861	326	6	slope	slope	NOUN
admet-2861	326	7	of	of	ADP
admet-2861	326	8	the	the	DET
admet-2861	326	9	dissolution	dissolution	NOUN
admet-2861	326	10	curve	curve	NOUN
admet-2861	326	11	of	of	ADP
admet-2861	326	12	the	the	DET
admet-2861	326	13	bdp	bdp	PROPN
admet-2861	326	14	was	be	AUX
admet-2861	326	15	observed	observe	VERB
admet-2861	326	16	with	with	ADP
admet-2861	326	17	cmax	cmax	NOUN
admet-2861	326	18	,	,	PUNCT
admet-2861	326	19	but	but	CCONJ
admet-2861	326	20	not	not	PART
admet-2861	326	21	with	with	ADP
admet-2861	326	22	t1/2	t1/2	NOUN
admet-2861	326	23	.	.	PUNCT
admet-2861	327	1	due	due	ADP
admet-2861	327	2	to	to	ADP
admet-2861	327	3	the	the	DET
admet-2861	327	4	same	same	ADJ
admet-2861	327	5	value	value	NOUN
admet-2861	327	6	of	of	ADP
admet-2861	327	7	tmax	tmax	PRON
admet-2861	327	8	for	for	ADP
admet-2861	327	9	all	all	DET
admet-2861	327	10	3	3	NUM
admet-2861	327	11	products	product	NOUN
admet-2861	327	12	,	,	PUNCT
admet-2861	327	13	correlation	correlation	NOUN
admet-2861	327	14	for	for	ADP
admet-2861	327	15	that	that	DET
admet-2861	327	16	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	327	17	parameter	parameter	NOUN
admet-2861	327	18	was	be	AUX
admet-2861	327	19	not	not	PART
admet-2861	327	20	calculated	calculate	VERB
admet-2861	327	21	.	.	PUNCT
admet-2861	328	1	a	a	DET
admet-2861	328	2	very	very	ADV
admet-2861	328	3	good	good	ADJ
admet-2861	328	4	correlation	correlation	NOUN
admet-2861	328	5	was	be	AUX
admet-2861	328	6	noticeable	noticeable	ADJ
admet-2861	328	7	with	with	ADP
admet-2861	328	8	k10	k10	NOUN
admet-2861	328	9	and	and	CCONJ
admet-2861	328	10	a	a	DET
admet-2861	328	11	lesser	less	ADJ
admet-2861	328	12	one	one	NOUN
admet-2861	328	13	with	with	ADP
admet-2861	328	14	ka	ka	PROPN
admet-2861	328	15	(	(	PUNCT
admet-2861	328	16	table	table	NOUN
admet-2861	328	17	12	12	NUM
admet-2861	328	18	)	)	PUNCT
admet-2861	328	19	.	.	PUNCT
admet-2861	329	1	since	since	SCONJ
admet-2861	329	2	k10	k10	PROPN
admet-2861	329	3	defines	define	VERB
admet-2861	329	4	the	the	DET
admet-2861	329	5	process	process	NOUN
admet-2861	329	6	of	of	ADP
admet-2861	329	7	drug	drug	NOUN
admet-2861	329	8	elimination	elimination	NOUN
admet-2861	329	9	from	from	ADP
admet-2861	329	10	the	the	DET
admet-2861	329	11	primary	primary	ADJ
admet-2861	329	12	compartment	compartment	NOUN
admet-2861	329	13	,	,	PUNCT
admet-2861	329	14	there	there	PRON
admet-2861	329	15	is	be	VERB
admet-2861	329	16	no	no	DET
admet-2861	329	17	basis	basis	NOUN
admet-2861	329	18	for	for	ADP
admet-2861	329	19	its	its	PRON
admet-2861	329	20	connection	connection	NOUN
admet-2861	329	21	with	with	ADP
admet-2861	329	22	the	the	DET
admet-2861	329	23	parameters	parameter	NOUN
admet-2861	329	24	that	that	PRON
admet-2861	329	25	define	define	VERB
admet-2861	329	26	the	the	DET
admet-2861	329	27	dissolution	dissolution	NOUN
admet-2861	329	28	rate	rate	NOUN
admet-2861	329	29	,	,	PUNCT
admet-2861	329	30	which	which	PRON
admet-2861	329	31	is	be	AUX
admet-2861	329	32	a	a	DET
admet-2861	329	33	prerequisite	prerequisite	NOUN
admet-2861	329	34	for	for	ADP
admet-2861	329	35	absorption	absorption	NOUN
admet-2861	329	36	.	.	PUNCT
admet-2861	330	1	on	on	ADP
admet-2861	330	2	the	the	DET
admet-2861	330	3	other	other	ADJ
admet-2861	330	4	hand	hand	NOUN
admet-2861	330	5	,	,	PUNCT
admet-2861	330	6	flipflop	flipflop	NOUN
admet-2861	330	7	kinetics	kinetic	NOUN
admet-2861	330	8	could	could	AUX
admet-2861	330	9	explain	explain	VERB
admet-2861	330	10	such	such	ADJ
admet-2861	330	11	correlations	correlation	NOUN
admet-2861	330	12	.	.	PUNCT
admet-2861	331	1	in	in	ADP
admet-2861	331	2	the	the	DET
admet-2861	331	3	flip	flip	NOUN
admet-2861	331	4	-	-	PUNCT
admet-2861	331	5	flop	flop	NOUN
admet-2861	331	6	kinetics	kinetic	NOUN
admet-2861	331	7	,	,	PUNCT
admet-2861	331	8	there	there	PRON
admet-2861	331	9	is	be	VERB
admet-2861	331	10	an	an	DET
admet-2861	331	11	“	"	PUNCT
admet-2861	331	12	inversion	inversion	NOUN
admet-2861	331	13	”	"	PUNCT
admet-2861	331	14	of	of	ADP
admet-2861	331	15	the	the	DET
admet-2861	331	16	absorption	absorption	NOUN
admet-2861	331	17	and	and	CCONJ
admet-2861	331	18	elimination	elimination	NOUN
admet-2861	331	19	constants	constant	NOUN
admet-2861	331	20	estimated	estimate	VERB
admet-2861	331	21	from	from	ADP
admet-2861	331	22	the	the	DET
admet-2861	331	23	cp	cp	PROPN
admet-2861	331	24	-	-	PROPN
admet-2861	331	25	t	t	PROPN
admet-2861	331	26	curve	curve	NOUN
admet-2861	331	27	.	.	PUNCT
admet-2861	332	1	this	this	DET
admet-2861	332	2	phenomenon	phenomenon	NOUN
admet-2861	332	3	usually	usually	ADV
admet-2861	332	4	occurs	occur	VERB
admet-2861	332	5	in	in	ADP
admet-2861	332	6	products	product	NOUN
admet-2861	332	7	with	with	ADP
admet-2861	332	8	a	a	DET
admet-2861	332	9	prolonged	prolonged	ADJ
admet-2861	332	10	or	or	CCONJ
admet-2861	332	11	slow	slow	ADJ
admet-2861	332	12	release	release	NOUN
admet-2861	332	13	,	,	PUNCT
admet-2861	332	14	where	where	SCONJ
admet-2861	332	15	the	the	DET
admet-2861	332	16	absorption	absorption	NOUN
admet-2861	332	17	constant	constant	ADJ
admet-2861	332	18	is	be	AUX
admet-2861	332	19	significantly	significantly	ADV
admet-2861	332	20	lower	low	ADJ
admet-2861	332	21	than	than	ADP
admet-2861	332	22	the	the	DET
admet-2861	332	23	elimination	elimination	NOUN
admet-2861	332	24	constant	constant	ADJ
admet-2861	332	25	.	.	PUNCT
admet-2861	333	1	thus	thus	ADV
admet-2861	333	2	,	,	PUNCT
admet-2861	333	3	in	in	ADP
admet-2861	333	4	this	this	DET
admet-2861	333	5	case	case	NOUN
admet-2861	333	6	,	,	PUNCT
admet-2861	333	7	the	the	DET
admet-2861	333	8	apparent	apparent	ADJ
admet-2861	333	9	elimination	elimination	NOUN
admet-2861	333	10	constant	constant	ADJ
admet-2861	333	11	(	(	PUNCT
admet-2861	333	12	k10	k10	NOUN
admet-2861	333	13	)	)	PUNCT
admet-2861	333	14	would	would	AUX
admet-2861	333	15	represent	represent	VERB
admet-2861	333	16	the	the	DET
admet-2861	333	17	absorption	absorption	NOUN
admet-2861	333	18	constant	constant	ADJ
admet-2861	333	19	,	,	PUNCT
admet-2861	333	20	since	since	SCONJ
admet-2861	333	21	the	the	DET
admet-2861	333	22	possible	possible	ADJ
admet-2861	333	23	elimination	elimination	NOUN
admet-2861	333	24	rate	rate	NOUN
admet-2861	333	25	is	be	AUX
admet-2861	333	26	significantly	significantly	ADV
admet-2861	333	27	higher	high	ADJ
admet-2861	333	28	than	than	ADP
admet-2861	333	29	the	the	DET
admet-2861	333	30	absorption	absorption	NOUN
admet-2861	333	31	rate	rate	NOUN
admet-2861	333	32	,	,	PUNCT
admet-2861	333	33	and	and	CCONJ
admet-2861	333	34	the	the	DET
admet-2861	333	35	elimination	elimination	NOUN
admet-2861	333	36	itself	itself	PRON
admet-2861	333	37	would	would	AUX
admet-2861	333	38	occur	occur	VERB
admet-2861	333	39	at	at	ADP
admet-2861	333	40	the	the	DET
admet-2861	333	41	maximum	maximum	ADJ
admet-2861	333	42	rate	rate	NOUN
admet-2861	333	43	at	at	ADP
admet-2861	333	44	which	which	PRON
admet-2861	333	45	the	the	DET
admet-2861	333	46	active	active	ADJ
admet-2861	333	47	substance	substance	NOUN
admet-2861	333	48	is	be	AUX
admet-2861	333	49	absorbed	absorb	VERB
admet-2861	333	50	,	,	PUNCT
admet-2861	333	51	or	or	CCONJ
admet-2861	333	52	the	the	DET
admet-2861	333	53	rate	rate	NOUN
admet-2861	333	54	defined	define	VERB
admet-2861	333	55	by	by	ADP
admet-2861	333	56	the	the	DET
admet-2861	333	57	absorption	absorption	NOUN
admet-2861	333	58	constant	constant	ADJ
admet-2861	333	59	of	of	ADP
admet-2861	333	60	bdp	bdp	PROPN
admet-2861	333	61	.	.	PUNCT
admet-2861	334	1	therefore	therefore	ADV
admet-2861	334	2	,	,	PUNCT
admet-2861	334	3	the	the	DET
admet-2861	334	4	descending	descending	ADJ
admet-2861	334	5	part	part	NOUN
admet-2861	334	6	of	of	ADP
admet-2861	334	7	the	the	DET
admet-2861	334	8	cp	cp	PROPN
admet-2861	334	9	-	-	PROPN
admet-2861	334	10	t	t	PROPN
admet-2861	334	11	curve	curve	NOUN
admet-2861	334	12	,	,	PUNCT
admet-2861	334	13	from	from	ADP
admet-2861	334	14	which	which	PRON
admet-2861	334	15	the	the	DET
admet-2861	334	16	elimination	elimination	NOUN
admet-2861	334	17	constant	constant	ADJ
admet-2861	334	18	is	be	AUX
admet-2861	334	19	usually	usually	ADV
admet-2861	334	20	determined	determine	VERB
admet-2861	334	21	,	,	PUNCT
admet-2861	334	22	is	be	AUX
admet-2861	334	23	related	relate	VERB
admet-2861	334	24	to	to	ADP
admet-2861	334	25	the	the	DET
admet-2861	334	26	admet	admet	PROPN
admet-2861	334	27	&	&	CCONJ
admet-2861	334	28	dmpk	dmpk	PROPN
admet-2861	334	29	13	13	NUM
admet-2861	334	30	(	(	PUNCT
admet-2861	334	31	)	)	PUNCT
admet-2861	334	32	(	(	PUNCT
admet-2861	334	33	2025	2025	NUM
admet-2861	334	34	)	)	PUNCT
admet-2861	334	35	2861	2861	NUM
admet-2861	334	36	development	development	NOUN
admet-2861	334	37	of	of	ADP
admet-2861	334	38	a	a	DET
admet-2861	334	39	biorelevant	biorelevant	ADJ
admet-2861	334	40	dissolution	dissolution	NOUN
admet-2861	334	41	method	method	NOUN
admet-2861	334	42	for	for	ADP
admet-2861	334	43	inhalation	inhalation	NOUN
admet-2861	334	44	products	product	NOUN
admet-2861	334	45	doi	doi	NOUN
admet-2861	334	46	:	:	PUNCT
admet-2861	334	47	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	334	48	19	19	NUM
admet-2861	334	49	absorption	absorption	NOUN
admet-2861	334	50	constant	constant	ADJ
admet-2861	335	1	[	[	X
admet-2861	335	2	58,59	58,59	NUM
admet-2861	335	3	]	]	PUNCT
admet-2861	335	4	.	.	PUNCT
admet-2861	336	1	to	to	PART
admet-2861	336	2	confirm	confirm	VERB
admet-2861	336	3	that	that	SCONJ
admet-2861	336	4	a	a	DET
admet-2861	336	5	particular	particular	ADJ
admet-2861	336	6	preparation	preparation	NOUN
admet-2861	336	7	underwent	underwent	NOUN
admet-2861	336	8	flip	flip	NOUN
admet-2861	336	9	-	-	PUNCT
admet-2861	336	10	flop	flop	NOUN
admet-2861	336	11	kinetics	kinetic	NOUN
admet-2861	336	12	,	,	PUNCT
admet-2861	336	13	a	a	DET
admet-2861	336	14	comparison	comparison	NOUN
admet-2861	336	15	with	with	ADP
admet-2861	336	16	the	the	DET
admet-2861	336	17	calculated	calculate	VERB
admet-2861	336	18	elimination	elimination	NOUN
admet-2861	336	19	constant	constant	ADJ
admet-2861	336	20	during	during	ADP
admet-2861	336	21	i.v	i.v	PROPN
admet-2861	336	22	.	.	PUNCT
admet-2861	336	23	administration	administration	NOUN
admet-2861	336	24	of	of	ADP
admet-2861	336	25	the	the	DET
admet-2861	336	26	test	test	NOUN
admet-2861	336	27	substance	substance	NOUN
admet-2861	336	28	is	be	AUX
admet-2861	336	29	usually	usually	ADV
admet-2861	336	30	used	use	VERB
admet-2861	336	31	.	.	PUNCT
admet-2861	337	1	if	if	SCONJ
admet-2861	337	2	the	the	DET
admet-2861	337	3	elimination	elimination	NOUN
admet-2861	337	4	constant	constant	NOUN
admet-2861	337	5	obtained	obtain	VERB
admet-2861	337	6	after	after	SCONJ
admet-2861	337	7	i.v	i.v	PROPN
admet-2861	337	8	.	.	PROPN
admet-2861	337	9	administration	administration	NOUN
admet-2861	337	10	is	be	AUX
admet-2861	337	11	close	close	ADJ
admet-2861	337	12	to	to	ADP
admet-2861	337	13	that	that	PRON
admet-2861	337	14	obtained	obtain	VERB
admet-2861	337	15	in	in	ADP
admet-2861	337	16	the	the	DET
admet-2861	337	17	preparation	preparation	NOUN
admet-2861	337	18	where	where	SCONJ
admet-2861	337	19	flipflop	flipflop	NOUN
admet-2861	337	20	kinetics	kinetic	NOUN
admet-2861	337	21	is	be	AUX
admet-2861	337	22	suspected	suspect	VERB
admet-2861	337	23	;	;	PUNCT
admet-2861	337	24	this	this	PRON
admet-2861	337	25	is	be	AUX
admet-2861	337	26	considered	consider	VERB
admet-2861	337	27	evidence	evidence	NOUN
admet-2861	337	28	that	that	SCONJ
admet-2861	337	29	it	it	PRON
admet-2861	337	30	is	be	AUX
admet-2861	337	31	present	present	ADJ
admet-2861	337	32	in	in	ADP
admet-2861	337	33	that	that	DET
admet-2861	337	34	case	case	NOUN
admet-2861	337	35	.	.	PUNCT
admet-2861	338	1	conversely	conversely	ADV
admet-2861	338	2	,	,	PUNCT
admet-2861	338	3	the	the	DET
admet-2861	338	4	similarity	similarity	NOUN
admet-2861	338	5	of	of	ADP
admet-2861	338	6	the	the	DET
admet-2861	338	7	elimination	elimination	NOUN
admet-2861	338	8	constant	constant	ADJ
admet-2861	338	9	in	in	ADP
admet-2861	338	10	i.v	i.v	PROPN
admet-2861	338	11	.	.	PROPN
admet-2861	338	12	administration	administration	PROPN
admet-2861	338	13	,	,	PUNCT
admet-2861	338	14	and	and	CCONJ
admet-2861	338	15	in	in	ADP
admet-2861	338	16	products	product	NOUN
admet-2861	338	17	where	where	SCONJ
admet-2861	338	18	the	the	DET
admet-2861	338	19	flip	flip	NOUN
admet-2861	338	20	-	-	PUNCT
admet-2861	338	21	flop	flop	NOUN
admet-2861	338	22	kinetics	kinetic	NOUN
admet-2861	338	23	are	be	AUX
admet-2861	338	24	suspected	suspect	VERB
admet-2861	338	25	,	,	PUNCT
admet-2861	338	26	it	it	PRON
admet-2861	338	27	indicates	indicate	VERB
admet-2861	338	28	that	that	SCONJ
admet-2861	338	29	flip	flip	NOUN
admet-2861	338	30	-	-	PUNCT
admet-2861	338	31	flop	flop	NOUN
admet-2861	338	32	kinetics	kinetic	NOUN
admet-2861	338	33	do	do	AUX
admet-2861	338	34	not	not	PART
admet-2861	338	35	occur	occur	VERB
admet-2861	338	36	in	in	ADP
admet-2861	338	37	that	that	DET
admet-2861	338	38	case	case	NOUN
admet-2861	339	1	[	[	X
admet-2861	339	2	60	60	NUM
admet-2861	339	3	]	]	PUNCT
admet-2861	339	4	.	.	PUNCT
admet-2861	340	1	elimination	elimination	NOUN
admet-2861	340	2	and	and	CCONJ
admet-2861	340	3	absorption	absorption	NOUN
admet-2861	340	4	constants	constant	NOUN
admet-2861	340	5	calculated	calculate	VERB
admet-2861	340	6	from	from	ADP
admet-2861	340	7	the	the	DET
admet-2861	340	8	cp	cp	PROPN
admet-2861	340	9	-	-	PUNCT
admet-2861	340	10	t	t	NOUN
admet-2861	340	11	curves	curve	NOUN
admet-2861	340	12	obtained	obtain	VERB
admet-2861	340	13	from	from	ADP
admet-2861	340	14	the	the	DET
admet-2861	340	15	developed	develop	VERB
admet-2861	340	16	in	in	ADP
admet-2861	340	17	-	-	PUNCT
admet-2861	340	18	silico	silico	NOUN
admet-2861	340	19	models	model	NOUN
admet-2861	340	20	are	be	AUX
admet-2861	340	21	given	give	VERB
admet-2861	340	22	in	in	ADP
admet-2861	340	23	table	table	NOUN
admet-2861	340	24	9	9	NUM
admet-2861	340	25	.	.	PUNCT
admet-2861	341	1	the	the	DET
admet-2861	341	2	elimination	elimination	NOUN
admet-2861	341	3	constant	constant	NOUN
admet-2861	341	4	based	base	VERB
admet-2861	341	5	on	on	ADP
admet-2861	341	6	the	the	DET
admet-2861	341	7	in	in	ADP
admet-2861	341	8	-	-	PUNCT
admet-2861	341	9	silico	silico	NOUN
admet-2861	341	10	model	model	NOUN
admet-2861	341	11	of	of	ADP
admet-2861	341	12	bdp	bdp	PROPN
admet-2861	341	13	i.v	i.v	PROPN
admet-2861	341	14	.	.	PROPN
admet-2861	341	15	administration	administration	PROPN
admet-2861	341	16	was	be	AUX
admet-2861	341	17	17.15	17.15	NUM
admet-2861	341	18	h-1	h-1	NOUN
admet-2861	341	19	.	.	PUNCT
admet-2861	342	1	the	the	DET
admet-2861	342	2	obtained	obtain	VERB
admet-2861	342	3	value	value	NOUN
admet-2861	342	4	was	be	AUX
admet-2861	342	5	much	much	ADV
admet-2861	342	6	closer	close	ADJ
admet-2861	342	7	to	to	ADP
admet-2861	342	8	the	the	DET
admet-2861	342	9	values	value	NOUN
admet-2861	342	10	of	of	ADP
admet-2861	342	11	the	the	DET
admet-2861	342	12	ka	ka	PROPN
admet-2861	342	13	calculated	calculate	VERB
admet-2861	342	14	for	for	ADP
admet-2861	342	15	administration	administration	NOUN
admet-2861	342	16	via	via	ADP
admet-2861	342	17	the	the	DET
admet-2861	342	18	respiratory	respiratory	ADJ
admet-2861	342	19	tract	tract	NOUN
admet-2861	342	20	(	(	PUNCT
admet-2861	342	21	from	from	ADP
admet-2861	342	22	37.22	37.22	NUM
admet-2861	342	23	to	to	ADP
admet-2861	342	24	44.01	44.01	NUM
admet-2861	342	25	h-1	h-1	NOUN
admet-2861	342	26	)	)	PUNCT
admet-2861	342	27	than	than	ADP
admet-2861	342	28	to	to	ADP
admet-2861	342	29	the	the	DET
admet-2861	342	30	values	value	NOUN
admet-2861	342	31	obtained	obtain	VERB
admet-2861	342	32	for	for	ADP
admet-2861	342	33	the	the	DET
admet-2861	342	34	elimination	elimination	NOUN
admet-2861	342	35	constant	constant	ADJ
admet-2861	342	36	(	(	PUNCT
admet-2861	342	37	from	from	ADP
admet-2861	342	38	6.7910	6.7910	NUM
admet-2861	342	39	-	-	SYM
admet-2861	342	40	3	3	NUM
admet-2861	342	41	to	to	ADP
admet-2861	342	42	2.5310	2.5310	NUM
admet-2861	342	43	-	-	SYM
admet-2861	342	44	3	3	NUM
admet-2861	342	45	h-1	h-1	NOUN
admet-2861	342	46	)	)	PUNCT
admet-2861	342	47	,	,	PUNCT
admet-2861	342	48	which	which	PRON
admet-2861	342	49	indicates	indicate	VERB
admet-2861	342	50	the	the	DET
admet-2861	342	51	possibility	possibility	NOUN
admet-2861	342	52	of	of	ADP
admet-2861	342	53	the	the	DET
admet-2861	342	54	presence	presence	NOUN
admet-2861	342	55	of	of	ADP
admet-2861	342	56	flip	flip	NOUN
admet-2861	342	57	-	-	PUNCT
admet-2861	342	58	flop	flop	NOUN
admet-2861	342	59	kinetics	kinetic	NOUN
admet-2861	342	60	.	.	PUNCT
admet-2861	343	1	the	the	DET
admet-2861	343	2	“	"	PUNCT
admet-2861	343	3	interchange	interchange	NOUN
admet-2861	343	4	”	"	PUNCT
admet-2861	343	5	of	of	ADP
admet-2861	343	6	the	the	DET
admet-2861	343	7	absorption	absorption	NOUN
admet-2861	343	8	and	and	CCONJ
admet-2861	343	9	elimination	elimination	NOUN
admet-2861	343	10	constants	constant	NOUN
admet-2861	343	11	is	be	AUX
admet-2861	343	12	characteristic	characteristic	ADJ
admet-2861	343	13	in	in	ADP
admet-2861	343	14	cases	case	NOUN
admet-2861	343	15	where	where	SCONJ
admet-2861	343	16	the	the	DET
admet-2861	343	17	release	release	NOUN
admet-2861	343	18	and/or	and/or	CCONJ
admet-2861	343	19	dissolution	dissolution	NOUN
admet-2861	343	20	of	of	ADP
admet-2861	343	21	the	the	DET
admet-2861	343	22	active	active	ADJ
admet-2861	343	23	substance	substance	NOUN
admet-2861	343	24	is	be	AUX
admet-2861	343	25	slowed	slow	VERB
admet-2861	343	26	down	down	ADP
admet-2861	343	27	.	.	PUNCT
admet-2861	344	1	this	this	PRON
admet-2861	344	2	may	may	AUX
admet-2861	344	3	be	be	AUX
admet-2861	344	4	due	due	ADJ
admet-2861	344	5	to	to	ADP
admet-2861	344	6	the	the	DET
admet-2861	344	7	low	low	ADJ
admet-2861	344	8	solubility	solubility	NOUN
admet-2861	344	9	of	of	ADP
admet-2861	344	10	the	the	DET
admet-2861	344	11	active	active	ADJ
admet-2861	344	12	substance	substance	NOUN
admet-2861	344	13	or	or	CCONJ
admet-2861	344	14	the	the	DET
admet-2861	344	15	modified	modify	VERB
admet-2861	344	16	release	release	NOUN
admet-2861	344	17	formulation	formulation	NOUN
admet-2861	344	18	.	.	PUNCT
admet-2861	345	1	although	although	SCONJ
admet-2861	345	2	bdp	bdp	PROPN
admet-2861	345	3	has	have	VERB
admet-2861	345	4	low	low	ADJ
admet-2861	345	5	solubility	solubility	NOUN
admet-2861	345	6	,	,	PUNCT
admet-2861	345	7	absorption	absorption	NOUN
admet-2861	345	8	is	be	AUX
admet-2861	345	9	further	far	ADV
admet-2861	345	10	slowed	slow	VERB
admet-2861	345	11	by	by	ADP
admet-2861	345	12	the	the	DET
admet-2861	345	13	effect	effect	NOUN
admet-2861	345	14	of	of	ADP
admet-2861	345	15	the	the	DET
admet-2861	345	16	extremely	extremely	ADV
admet-2861	345	17	small	small	ADJ
admet-2861	345	18	volume	volume	NOUN
admet-2861	345	19	of	of	ADP
admet-2861	345	20	pulmonary	pulmonary	ADJ
admet-2861	345	21	fluid	fluid	NOUN
admet-2861	345	22	available	available	ADJ
admet-2861	345	23	for	for	ADP
admet-2861	345	24	dissolution	dissolution	NOUN
admet-2861	345	25	and	and	CCONJ
admet-2861	345	26	by	by	ADP
admet-2861	345	27	mechanisms	mechanism	NOUN
admet-2861	345	28	of	of	ADP
admet-2861	345	29	particle	particle	NOUN
admet-2861	345	30	removal	removal	NOUN
admet-2861	345	31	from	from	ADP
admet-2861	345	32	the	the	DET
admet-2861	345	33	respiratory	respiratory	ADJ
admet-2861	345	34	tract	tract	NOUN
admet-2861	345	35	,	,	PUNCT
admet-2861	345	36	which	which	PRON
admet-2861	345	37	further	far	ADV
admet-2861	345	38	reduces	reduce	VERB
admet-2861	345	39	the	the	DET
admet-2861	345	40	ratio	ratio	NOUN
admet-2861	345	41	of	of	ADP
admet-2861	345	42	absorbed	absorb	VERB
admet-2861	345	43	active	active	ADJ
admet-2861	345	44	substance	substance	NOUN
admet-2861	345	45	[	[	X
admet-2861	345	46	61	61	NUM
admet-2861	345	47	]	]	PUNCT
admet-2861	345	48	.	.	PUNCT
admet-2861	346	1	based	base	VERB
admet-2861	346	2	on	on	ADP
admet-2861	346	3	this	this	PRON
admet-2861	346	4	,	,	PUNCT
admet-2861	346	5	it	it	PRON
admet-2861	346	6	can	can	AUX
admet-2861	346	7	be	be	AUX
admet-2861	346	8	inferred	infer	VERB
admet-2861	346	9	that	that	SCONJ
admet-2861	346	10	the	the	DET
admet-2861	346	11	calculated	calculate	VERB
admet-2861	346	12	k10	k10	NOUN
admet-2861	346	13	is	be	AUX
admet-2861	346	14	a	a	DET
admet-2861	346	15	measure	measure	NOUN
admet-2861	346	16	of	of	ADP
admet-2861	346	17	the	the	DET
admet-2861	346	18	absorption	absorption	NOUN
admet-2861	346	19	rate	rate	NOUN
admet-2861	346	20	.	.	PUNCT
admet-2861	347	1	thus	thus	ADV
admet-2861	347	2	,	,	PUNCT
admet-2861	347	3	the	the	DET
admet-2861	347	4	correlation	correlation	NOUN
admet-2861	347	5	with	with	ADP
admet-2861	347	6	the	the	DET
admet-2861	347	7	slope	slope	NOUN
admet-2861	347	8	of	of	ADP
admet-2861	347	9	the	the	DET
admet-2861	347	10	release	release	NOUN
admet-2861	347	11	rate	rate	NOUN
admet-2861	347	12	curve	curve	NOUN
admet-2861	347	13	becomes	become	VERB
admet-2861	347	14	logical	logical	ADJ
admet-2861	347	15	and	and	CCONJ
admet-2861	347	16	significant	significant	ADJ
admet-2861	347	17	for	for	ADP
admet-2861	347	18	establishing	establish	VERB
admet-2861	347	19	the	the	DET
admet-2861	347	20	claim	claim	NOUN
admet-2861	347	21	about	about	ADP
admet-2861	347	22	the	the	DET
admet-2861	347	23	in	in	ADP
admet-2861	347	24	vivo	vivo	ADJ
admet-2861	347	25	predictability	predictability	NOUN
admet-2861	347	26	of	of	ADP
admet-2861	347	27	the	the	DET
admet-2861	347	28	developed	develop	VERB
admet-2861	347	29	method	method	NOUN
admet-2861	347	30	for	for	ADP
admet-2861	347	31	dissolution	dissolution	NOUN
admet-2861	347	32	testing	testing	NOUN
admet-2861	347	33	of	of	ADP
admet-2861	347	34	inhaled	inhaled	ADJ
admet-2861	347	35	products	product	NOUN
admet-2861	347	36	containing	contain	VERB
admet-2861	347	37	bdp	bdp	PROPN
admet-2861	347	38	.	.	PUNCT
admet-2861	348	1	the	the	DET
admet-2861	348	2	obtained	obtain	VERB
admet-2861	348	3	correlation	correlation	NOUN
admet-2861	348	4	was	be	AUX
admet-2861	348	5	achieved	achieve	VERB
admet-2861	348	6	at	at	ADP
admet-2861	348	7	two	two	NUM
admet-2861	348	8	points	point	NOUN
admet-2861	348	9	:	:	PUNCT
admet-2861	348	10	between	between	ADP
admet-2861	348	11	ka	ka	PROPN
admet-2861	348	12	and	and	CCONJ
admet-2861	348	13	the	the	DET
admet-2861	348	14	slope	slope	NOUN
admet-2861	348	15	of	of	ADP
admet-2861	348	16	the	the	DET
admet-2861	348	17	dissolution	dissolution	NOUN
admet-2861	348	18	curve	curve	NOUN
admet-2861	348	19	and	and	CCONJ
admet-2861	348	20	cmax	cmax	NOUN
admet-2861	348	21	and	and	CCONJ
admet-2861	348	22	the	the	DET
admet-2861	348	23	slope	slope	NOUN
admet-2861	348	24	of	of	ADP
admet-2861	348	25	the	the	DET
admet-2861	348	26	dissolution	dissolution	NOUN
admet-2861	348	27	curve	curve	NOUN
admet-2861	348	28	of	of	ADP
admet-2861	348	29	the	the	DET
admet-2861	348	30	active	active	ADJ
admet-2861	348	31	substance	substance	NOUN
admet-2861	348	32	from	from	ADP
admet-2861	348	33	the	the	DET
admet-2861	348	34	preparation	preparation	NOUN
admet-2861	348	35	,	,	PUNCT
admet-2861	348	36	which	which	PRON
admet-2861	348	37	corresponds	correspond	VERB
admet-2861	348	38	to	to	ADP
admet-2861	348	39	the	the	DET
admet-2861	348	40	multiple	multiple	ADJ
admet-2861	348	41	level	level	NOUN
admet-2861	348	42	c	c	NOUN
admet-2861	348	43	correlation	correlation	NOUN
admet-2861	348	44	as	as	SCONJ
admet-2861	348	45	defined	define	VERB
admet-2861	348	46	in	in	ADP
admet-2861	348	47	the	the	DET
admet-2861	348	48	usp	usp	NOUN
admet-2861	348	49	.	.	PUNCT
admet-2861	349	1	all	all	DET
admet-2861	349	2	the	the	DET
admet-2861	349	3	predicted	predict	VERB
admet-2861	349	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	349	5	parameters	parameter	NOUN
admet-2861	349	6	were	be	AUX
admet-2861	349	7	obtained	obtain	VERB
admet-2861	349	8	as	as	ADP
admet-2861	349	9	a	a	DET
admet-2861	349	10	result	result	NOUN
admet-2861	349	11	of	of	ADP
admet-2861	349	12	in	in	ADP
admet-2861	349	13	silico	silico	NOUN
admet-2861	349	14	simulations	simulation	NOUN
admet-2861	349	15	,	,	PUNCT
admet-2861	349	16	which	which	PRON
admet-2861	349	17	showed	show	VERB
admet-2861	349	18	good	good	ADJ
admet-2861	349	19	agreement	agreement	NOUN
admet-2861	349	20	with	with	ADP
admet-2861	349	21	the	the	DET
admet-2861	349	22	in	in	ADP
admet-2861	349	23	vivo	vivo	ADJ
admet-2861	349	24	data	datum	NOUN
admet-2861	349	25	from	from	ADP
admet-2861	349	26	the	the	DET
admet-2861	349	27	literature	literature	NOUN
admet-2861	349	28	.	.	PUNCT
admet-2861	350	1	the	the	DET
admet-2861	350	2	obtained	obtain	VERB
admet-2861	350	3	correlation	correlation	NOUN
admet-2861	350	4	indicates	indicate	VERB
admet-2861	350	5	that	that	SCONJ
admet-2861	350	6	the	the	DET
admet-2861	350	7	dissolution	dissolution	ADJ
admet-2861	350	8	rate	rate	NOUN
admet-2861	350	9	of	of	ADP
admet-2861	350	10	bdp	bdp	PROPN
admet-2861	350	11	in	in	ADP
admet-2861	350	12	the	the	DET
admet-2861	350	13	tested	test	VERB
admet-2861	350	14	dissolution	dissolution	NOUN
admet-2861	350	15	system	system	NOUN
admet-2861	350	16	strongly	strongly	ADV
admet-2861	350	17	correlated	correlate	VERB
admet-2861	350	18	with	with	ADP
admet-2861	350	19	the	the	DET
admet-2861	350	20	data	datum	NOUN
admet-2861	350	21	obtained	obtain	VERB
admet-2861	350	22	by	by	ADP
admet-2861	350	23	the	the	DET
admet-2861	350	24	in	in	ADP
admet-2861	350	25	silico	silico	NOUN
admet-2861	350	26	method	method	NOUN
admet-2861	350	27	.	.	PUNCT
admet-2861	351	1	it	it	PRON
admet-2861	351	2	would	would	AUX
admet-2861	351	3	be	be	AUX
admet-2861	351	4	optimal	optimal	ADJ
admet-2861	351	5	to	to	PART
admet-2861	351	6	establish	establish	VERB
admet-2861	351	7	a	a	DET
admet-2861	351	8	correlation	correlation	NOUN
admet-2861	351	9	between	between	ADP
admet-2861	351	10	the	the	DET
admet-2861	351	11	in	in	ADP
admet-2861	351	12	vitro	vitro	X
admet-2861	351	13	and	and	CCONJ
admet-2861	351	14	in	in	ADP
admet-2861	351	15	vivo	vivo	ADJ
admet-2861	351	16	data	datum	NOUN
admet-2861	351	17	;	;	PUNCT
admet-2861	351	18	however	however	ADV
admet-2861	351	19	,	,	PUNCT
admet-2861	351	20	the	the	DET
admet-2861	351	21	lack	lack	NOUN
admet-2861	351	22	of	of	ADP
admet-2861	351	23	published	publish	VERB
admet-2861	351	24	data	datum	NOUN
admet-2861	351	25	on	on	ADP
admet-2861	351	26	the	the	DET
admet-2861	351	27	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	351	28	profiles	profile	NOUN
admet-2861	351	29	of	of	ADP
admet-2861	351	30	inhalation	inhalation	NOUN
admet-2861	351	31	products	product	NOUN
admet-2861	351	32	containing	contain	VERB
admet-2861	351	33	bdp	bdp	PROPN
admet-2861	351	34	makes	make	VERB
admet-2861	351	35	such	such	DET
admet-2861	351	36	a	a	DET
admet-2861	351	37	comparison	comparison	NOUN
admet-2861	351	38	challenging	challenge	VERB
admet-2861	351	39	.	.	PUNCT
admet-2861	352	1	also	also	ADV
admet-2861	352	2	,	,	PUNCT
admet-2861	352	3	the	the	DET
admet-2861	352	4	selection	selection	NOUN
admet-2861	352	5	of	of	ADP
admet-2861	352	6	inadequate	inadequate	ADJ
admet-2861	352	7	sampling	sampling	NOUN
admet-2861	352	8	sites	site	NOUN
admet-2861	352	9	at	at	ADP
admet-2861	352	10	the	the	DET
admet-2861	352	11	beginning	beginning	NOUN
admet-2861	352	12	of	of	ADP
admet-2861	352	13	the	the	DET
admet-2861	352	14	sampling	sample	VERB
admet-2861	352	15	procedures	procedure	NOUN
admet-2861	352	16	in	in	ADP
admet-2861	352	17	in	in	ADP
admet-2861	352	18	vivo	vivo	ADJ
admet-2861	352	19	studies	study	NOUN
admet-2861	352	20	significantly	significantly	ADV
admet-2861	352	21	impacted	impact	VERB
admet-2861	352	22	the	the	DET
admet-2861	352	23	obtained	obtain	VERB
admet-2861	352	24	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	352	25	parameters	parameter	NOUN
admet-2861	352	26	.	.	PUNCT
admet-2861	353	1	this	this	PRON
admet-2861	353	2	is	be	AUX
admet-2861	353	3	especially	especially	ADV
admet-2861	353	4	visible	visible	ADJ
admet-2861	353	5	in	in	ADP
admet-2861	353	6	the	the	DET
admet-2861	353	7	calculation	calculation	NOUN
admet-2861	353	8	of	of	ADP
admet-2861	353	9	tmax	tmax	NOUN
admet-2861	353	10	and	and	CCONJ
admet-2861	353	11	cmax	cmax	VERB
admet-2861	353	12	,	,	PUNCT
admet-2861	353	13	and	and	CCONJ
admet-2861	353	14	thus	thus	ADV
admet-2861	353	15	also	also	ADV
admet-2861	353	16	on	on	ADP
admet-2861	353	17	ka	ka	PROPN
admet-2861	353	18	.	.	PUNCT
admet-2861	354	1	these	these	DET
admet-2861	354	2	shortcomings	shortcoming	NOUN
admet-2861	354	3	were	be	AUX
admet-2861	354	4	addressed	address	VERB
admet-2861	354	5	by	by	ADP
admet-2861	354	6	developing	develop	VERB
admet-2861	354	7	an	an	PRON
admet-2861	354	8	in	in	ADP
admet-2861	354	9	silico	silico	NOUN
admet-2861	354	10	model	model	NOUN
admet-2861	354	11	for	for	ADP
admet-2861	354	12	bdp	bdp	PROPN
admet-2861	354	13	.	.	PUNCT
admet-2861	355	1	additionally	additionally	ADV
admet-2861	355	2	,	,	PUNCT
admet-2861	355	3	using	use	VERB
admet-2861	355	4	this	this	DET
admet-2861	355	5	approach	approach	NOUN
admet-2861	355	6	,	,	PUNCT
admet-2861	355	7	the	the	DET
admet-2861	355	8	cp	cp	PROPN
admet-2861	355	9	-	-	PUNCT
admet-2861	355	10	t	t	PROPN
admet-2861	355	11	curve	curve	NOUN
admet-2861	355	12	can	can	AUX
admet-2861	355	13	be	be	AUX
admet-2861	355	14	derived	derive	VERB
admet-2861	355	15	for	for	ADP
admet-2861	355	16	new	new	ADJ
admet-2861	355	17	bdp	bdp	PROPN
admet-2861	355	18	inhalation	inhalation	NOUN
admet-2861	355	19	products	product	NOUN
admet-2861	355	20	based	base	VERB
admet-2861	355	21	on	on	ADP
admet-2861	355	22	their	their	PRON
admet-2861	355	23	biopharmaceutical	biopharmaceutical	ADJ
admet-2861	355	24	properties	property	NOUN
admet-2861	355	25	,	,	PUNCT
admet-2861	355	26	thus	thus	ADV
admet-2861	355	27	generating	generate	VERB
admet-2861	355	28	sufficient	sufficient	ADJ
admet-2861	355	29	data	datum	NOUN
admet-2861	355	30	to	to	PART
admet-2861	355	31	examine	examine	VERB
admet-2861	355	32	possible	possible	ADJ
admet-2861	355	33	correlations	correlation	NOUN
admet-2861	355	34	.	.	PUNCT
admet-2861	356	1	conclusions	conclusion	NOUN
admet-2861	356	2	the	the	DET
admet-2861	356	3	in	in	X
admet-2861	356	4	vitro	vitro	X
admet-2861	356	5	method	method	NOUN
admet-2861	356	6	was	be	AUX
admet-2861	356	7	developed	develop	VERB
admet-2861	356	8	to	to	PART
admet-2861	356	9	evaluate	evaluate	VERB
admet-2861	356	10	the	the	DET
admet-2861	356	11	dissolution	dissolution	NOUN
admet-2861	356	12	rate	rate	NOUN
admet-2861	356	13	of	of	ADP
admet-2861	356	14	the	the	DET
admet-2861	356	15	preparation	preparation	NOUN
admet-2861	356	16	for	for	ADP
admet-2861	356	17	inhalation	inhalation	NOUN
admet-2861	356	18	.	.	PUNCT
admet-2861	357	1	the	the	DET
admet-2861	357	2	method	method	NOUN
admet-2861	357	3	's	's	PART
admet-2861	357	4	settings	setting	NOUN
admet-2861	357	5	(	(	PUNCT
admet-2861	357	6	dissolution	dissolution	NOUN
admet-2861	357	7	medium	medium	NOUN
admet-2861	357	8	,	,	PUNCT
admet-2861	357	9	volume	volume	NOUN
admet-2861	357	10	of	of	ADP
admet-2861	357	11	medium	medium	NOUN
admet-2861	357	12	available	available	ADJ
admet-2861	357	13	for	for	ADP
admet-2861	357	14	particle	particle	NOUN
admet-2861	357	15	dissolution	dissolution	NOUN
admet-2861	357	16	,	,	PUNCT
admet-2861	357	17	fine	fine	ADJ
admet-2861	357	18	particle	particle	NOUN
admet-2861	357	19	fraction	fraction	NOUN
admet-2861	357	20	used	use	VERB
admet-2861	357	21	,	,	PUNCT
admet-2861	357	22	and	and	CCONJ
admet-2861	357	23	surfactant	surfactant	ADJ
admet-2861	357	24	usage	usage	NOUN
admet-2861	357	25	)	)	PUNCT
admet-2861	357	26	were	be	AUX
admet-2861	357	27	adjusted	adjust	VERB
admet-2861	357	28	to	to	ADP
admet-2861	357	29	loosely	loosely	ADV
admet-2861	357	30	mimic	mimic	VERB
admet-2861	357	31	conditions	condition	NOUN
admet-2861	357	32	in	in	ADP
admet-2861	357	33	the	the	DET
admet-2861	357	34	respiratory	respiratory	ADJ
admet-2861	357	35	tract	tract	NOUN
admet-2861	357	36	without	without	ADP
admet-2861	357	37	significantly	significantly	ADV
admet-2861	357	38	increasing	increase	VERB
admet-2861	357	39	the	the	DET
admet-2861	357	40	method	method	NOUN
admet-2861	357	41	's	's	PART
admet-2861	357	42	complexity	complexity	NOUN
admet-2861	357	43	or	or	CCONJ
admet-2861	357	44	reducing	reduce	VERB
admet-2861	357	45	its	its	PRON
admet-2861	357	46	acceptability	acceptability	NOUN
admet-2861	357	47	.	.	PUNCT
admet-2861	358	1	the	the	DET
admet-2861	358	2	developed	develop	VERB
admet-2861	358	3	method	method	NOUN
admet-2861	358	4	for	for	ADP
admet-2861	358	5	determining	determine	VERB
admet-2861	358	6	the	the	DET
admet-2861	358	7	dissolution	dissolution	NOUN
admet-2861	358	8	rate	rate	NOUN
admet-2861	358	9	revealed	reveal	VERB
admet-2861	358	10	fast	fast	ADJ
admet-2861	358	11	dissolution	dissolution	NOUN
admet-2861	358	12	and	and	CCONJ
admet-2861	358	13	did	do	AUX
admet-2861	358	14	not	not	PART
admet-2861	358	15	detect	detect	VERB
admet-2861	358	16	a	a	DET
admet-2861	358	17	difference	difference	NOUN
admet-2861	358	18	between	between	ADP
admet-2861	358	19	inhalation	inhalation	NOUN
admet-2861	358	20	products	product	NOUN
admet-2861	358	21	containing	contain	VERB
admet-2861	358	22	sx	sx	PROPN
admet-2861	358	23	,	,	PUNCT
admet-2861	358	24	a	a	DET
admet-2861	358	25	model	model	NOUN
admet-2861	358	26	substance	substance	NOUN
admet-2861	358	27	with	with	ADP
admet-2861	358	28	relatively	relatively	ADV
admet-2861	358	29	good	good	ADJ
admet-2861	358	30	solubility	solubility	NOUN
admet-2861	358	31	.	.	PUNCT
admet-2861	359	1	that	that	PRON
admet-2861	359	2	is	be	AUX
admet-2861	359	3	in	in	ADP
admet-2861	359	4	accordance	accordance	NOUN
admet-2861	359	5	with	with	ADP
admet-2861	359	6	the	the	DET
admet-2861	359	7	proposed	propose	VERB
admet-2861	359	8	ibcs	ibc	NOUN
admet-2861	359	9	[	[	X
admet-2861	359	10	62	62	NUM
admet-2861	359	11	]	]	PUNCT
admet-2861	359	12	,	,	PUNCT
admet-2861	359	13	where	where	SCONJ
admet-2861	359	14	sx	sx	PROPN
admet-2861	359	15	is	be	AUX
admet-2861	359	16	placed	place	VERB
admet-2861	359	17	in	in	ADP
admet-2861	359	18	group	group	NOUN
admet-2861	359	19	iii	iii	PROPN
admet-2861	359	20	and	and	CCONJ
admet-2861	359	21	close	close	ADJ
admet-2861	359	22	to	to	ADP
admet-2861	359	23	the	the	DET
admet-2861	359	24	border	border	NOUN
admet-2861	359	25	of	of	ADP
admet-2861	359	26	group	group	NOUN
admet-2861	359	27	i.	i.	NOUN
admet-2861	359	28	both	both	PRON
admet-2861	359	29	of	of	ADP
admet-2861	359	30	those	those	DET
admet-2861	359	31	groups	group	NOUN
admet-2861	359	32	are	be	AUX
admet-2861	359	33	composed	compose	VERB
admet-2861	359	34	of	of	ADP
admet-2861	359	35	substances	substance	NOUN
admet-2861	359	36	that	that	PRON
admet-2861	359	37	have	have	VERB
admet-2861	359	38	rapid	rapid	ADJ
admet-2861	359	39	dissolution	dissolution	NOUN
admet-2861	359	40	.	.	PUNCT
admet-2861	360	1	analysis	analysis	NOUN
admet-2861	360	2	of	of	ADP
admet-2861	360	3	the	the	DET
admet-2861	360	4	dissolution	dissolution	ADJ
admet-2861	360	5	profile	profile	NOUN
admet-2861	360	6	of	of	ADP
admet-2861	360	7	sx	sx	NOUN
admet-2861	360	8	using	use	VERB
admet-2861	360	9	model	model	NOUN
admet-2861	360	10	-	-	PUNCT
admet-2861	360	11	dependent	dependent	ADJ
admet-2861	360	12	methods	method	NOUN
admet-2861	360	13	did	do	AUX
admet-2861	360	14	not	not	PART
admet-2861	360	15	indicate	indicate	VERB
admet-2861	360	16	that	that	DET
admet-2861	360	17	dissolution	dissolution	NOUN
admet-2861	360	18	was	be	AUX
admet-2861	360	19	a	a	DET
admet-2861	360	20	rate	rate	NOUN
admet-2861	360	21	-	-	PUNCT
admet-2861	360	22	limiting	limit	VERB
admet-2861	360	23	process	process	NOUN
admet-2861	360	24	in	in	ADP
admet-2861	360	25	the	the	DET
admet-2861	360	26	release	release	NOUN
admet-2861	360	27	of	of	ADP
admet-2861	360	28	the	the	DET
admet-2861	360	29	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	360	30	a.	a.	NOUN
admet-2861	360	31	elezović	elezović	PROPN
admet-2861	360	32	et	et	PROPN
admet-2861	360	33	al	al	PROPN
admet-2861	360	34	.	.	PROPN
admet-2861	360	35	admet	admet	PROPN
admet-2861	360	36	&	&	CCONJ
admet-2861	360	37	dmpk	dmpk	PROPN
admet-2861	360	38	13(5	13(5	NUM
admet-2861	360	39	)	)	PUNCT
admet-2861	360	40	(	(	PUNCT
admet-2861	360	41	2025	2025	NUM
admet-2861	360	42	)	)	PUNCT
admet-2861	360	43	2861	2861	NUM
admet-2861	360	44	20	20	NUM
admet-2861	360	45	active	active	ADJ
admet-2861	360	46	substance	substance	NOUN
admet-2861	360	47	.	.	PUNCT
admet-2861	361	1	a	a	DET
admet-2861	361	2	developed	develop	VERB
admet-2861	361	3	dissolution	dissolution	NOUN
admet-2861	361	4	method	method	NOUN
admet-2861	361	5	detected	detect	VERB
admet-2861	361	6	differences	difference	NOUN
admet-2861	361	7	in	in	ADP
admet-2861	361	8	the	the	DET
admet-2861	361	9	dissolution	dissolution	ADJ
admet-2861	361	10	profiles	profile	NOUN
admet-2861	361	11	of	of	ADP
admet-2861	361	12	the	the	DET
admet-2861	361	13	analysed	analyse	VERB
admet-2861	361	14	inhalation	inhalation	NOUN
admet-2861	361	15	products	product	NOUN
admet-2861	361	16	containing	contain	VERB
admet-2861	361	17	bdp	bdp	PROPN
admet-2861	361	18	using	use	VERB
admet-2861	361	19	model	model	NOUN
admet-2861	361	20	-	-	PUNCT
admet-2861	361	21	independent	independent	ADJ
admet-2861	361	22	methods	method	NOUN
admet-2861	361	23	.	.	PUNCT
admet-2861	362	1	bdp	bdp	PROPN
admet-2861	362	2	is	be	AUX
admet-2861	362	3	classified	classify	VERB
admet-2861	362	4	in	in	ADP
admet-2861	362	5	group	group	PROPN
admet-2861	362	6	ii	ii	PROPN
admet-2861	362	7	of	of	ADP
admet-2861	362	8	ibcs	ibc	NOUN
admet-2861	362	9	,	,	PUNCT
admet-2861	362	10	which	which	PRON
admet-2861	362	11	is	be	AUX
admet-2861	362	12	characterized	characterize	VERB
admet-2861	362	13	by	by	ADP
admet-2861	362	14	dissolution	dissolution	NOUN
admet-2861	362	15	-	-	PUNCT
admet-2861	362	16	dependent	dependent	ADJ
admet-2861	362	17	absorptive	absorptive	ADJ
admet-2861	362	18	and	and	CCONJ
admet-2861	362	19	non	non	ADJ
admet-2861	362	20	-	-	ADJ
admet-2861	362	21	absorptive	absorptive	ADJ
admet-2861	362	22	clearance	clearance	NOUN
admet-2861	362	23	and	and	CCONJ
admet-2861	362	24	retention	retention	NOUN
admet-2861	362	25	[	[	X
admet-2861	362	26	62	62	NUM
admet-2861	362	27	]	]	PUNCT
admet-2861	362	28	.	.	PUNCT
admet-2861	363	1	analysis	analysis	NOUN
admet-2861	363	2	of	of	ADP
admet-2861	363	3	dissolution	dissolution	ADJ
admet-2861	363	4	profiles	profile	NOUN
admet-2861	363	5	using	use	VERB
admet-2861	363	6	model	model	NOUN
admet-2861	363	7	-	-	PUNCT
admet-2861	363	8	dependent	dependent	ADJ
admet-2861	363	9	methods	method	NOUN
admet-2861	363	10	indicated	indicate	VERB
admet-2861	363	11	that	that	SCONJ
admet-2861	363	12	dissolution	dissolution	NOUN
admet-2861	363	13	is	be	AUX
admet-2861	363	14	the	the	DET
admet-2861	363	15	rate	rate	NOUN
admet-2861	363	16	-	-	PUNCT
admet-2861	363	17	limiting	limit	VERB
admet-2861	363	18	factor	factor	NOUN
admet-2861	363	19	for	for	ADP
admet-2861	363	20	absorption	absorption	NOUN
admet-2861	363	21	of	of	ADP
admet-2861	363	22	bdp	bdp	PROPN
admet-2861	363	23	.	.	PUNCT
admet-2861	364	1	therefore	therefore	ADV
admet-2861	364	2	,	,	PUNCT
admet-2861	364	3	in	in	ADP
admet-2861	364	4	silico	silico	NOUN
admet-2861	364	5	adme	adme	NOUN
admet-2861	364	6	model	model	NOUN
admet-2861	364	7	of	of	ADP
admet-2861	364	8	bdp	bdp	PROPN
admet-2861	364	9	was	be	AUX
admet-2861	364	10	developed	develop	VERB
admet-2861	364	11	and	and	CCONJ
admet-2861	364	12	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	364	13	constants	constant	NOUN
admet-2861	364	14	(	(	PUNCT
admet-2861	364	15	cmax	cmax	NOUN
admet-2861	364	16	,	,	PUNCT
admet-2861	364	17	tmax	tmax	PROPN
admet-2861	364	18	,	,	PUNCT
admet-2861	364	19	ka	ka	PROPN
admet-2861	364	20	,	,	PUNCT
admet-2861	364	21	k10	k10	PROPN
admet-2861	364	22	)	)	PUNCT
admet-2861	364	23	linked	link	VERB
admet-2861	364	24	to	to	ADP
admet-2861	364	25	each	each	DET
admet-2861	364	26	tested	test	VERB
admet-2861	364	27	inhalation	inhalation	NOUN
admet-2861	364	28	product	product	NOUN
admet-2861	364	29	were	be	AUX
admet-2861	364	30	calculated	calculate	VERB
admet-2861	364	31	.	.	PUNCT
admet-2861	365	1	a	a	DET
admet-2861	365	2	good	good	ADJ
admet-2861	365	3	correlation	correlation	NOUN
admet-2861	365	4	was	be	AUX
admet-2861	365	5	found	find	VERB
admet-2861	365	6	between	between	ADP
admet-2861	365	7	the	the	DET
admet-2861	365	8	slope	slope	NOUN
admet-2861	365	9	of	of	ADP
admet-2861	365	10	the	the	DET
admet-2861	365	11	dissolution	dissolution	NOUN
admet-2861	365	12	curve	curve	NOUN
admet-2861	365	13	and	and	CCONJ
admet-2861	365	14	ka	ka	PROPN
admet-2861	365	15	(	(	PUNCT
admet-2861	365	16	represented	represent	VERB
admet-2861	365	17	by	by	ADP
admet-2861	365	18	k10	k10	PROPN
admet-2861	365	19	in	in	ADP
admet-2861	365	20	the	the	DET
admet-2861	365	21	case	case	NOUN
admet-2861	365	22	of	of	ADP
admet-2861	365	23	flip	flip	NOUN
admet-2861	365	24	-	-	PUNCT
admet-2861	365	25	flop	flop	NOUN
admet-2861	365	26	kinetics	kinetic	NOUN
admet-2861	365	27	)	)	PUNCT
admet-2861	365	28	and	and	CCONJ
admet-2861	365	29	cmax	cmax	NOUN
admet-2861	365	30	,	,	PUNCT
admet-2861	365	31	indicating	indicate	VERB
admet-2861	365	32	the	the	DET
admet-2861	365	33	clinical	clinical	ADJ
admet-2861	365	34	relevance	relevance	NOUN
admet-2861	365	35	of	of	ADP
admet-2861	365	36	the	the	DET
admet-2861	365	37	developed	develop	VERB
admet-2861	365	38	dissolution	dissolution	NOUN
admet-2861	365	39	method	method	NOUN
admet-2861	365	40	.	.	PUNCT
admet-2861	366	1	these	these	DET
admet-2861	366	2	results	result	NOUN
admet-2861	366	3	strongly	strongly	ADV
admet-2861	366	4	support	support	VERB
admet-2861	366	5	the	the	DET
admet-2861	366	6	importance	importance	NOUN
admet-2861	366	7	of	of	ADP
admet-2861	366	8	the	the	DET
admet-2861	366	9	dissolution	dissolution	NOUN
admet-2861	366	10	method	method	NOUN
admet-2861	366	11	in	in	ADP
admet-2861	366	12	quality	quality	NOUN
admet-2861	366	13	control	control	NOUN
admet-2861	366	14	and	and	CCONJ
admet-2861	366	15	bioequivalence	bioequivalence	NOUN
admet-2861	366	16	testing	testing	NOUN
admet-2861	366	17	of	of	ADP
admet-2861	366	18	inhalation	inhalation	NOUN
admet-2861	366	19	products	product	NOUN
admet-2861	366	20	containing	contain	VERB
admet-2861	366	21	class	class	NOUN
admet-2861	366	22	ii	ii	PROPN
admet-2861	366	23	and	and	CCONJ
admet-2861	366	24	iv	iv	NUM
admet-2861	366	25	drug	drug	NOUN
admet-2861	366	26	substances	substance	NOUN
admet-2861	366	27	.	.	PUNCT
admet-2861	367	1	considering	consider	VERB
admet-2861	367	2	the	the	DET
admet-2861	367	3	reawakened	reawaken	VERB
admet-2861	367	4	interest	interest	NOUN
admet-2861	367	5	of	of	ADP
admet-2861	367	6	regulatory	regulatory	ADJ
admet-2861	367	7	agencies	agency	NOUN
admet-2861	367	8	,	,	PUNCT
admet-2861	367	9	this	this	DET
admet-2861	367	10	method	method	NOUN
admet-2861	367	11	can	can	AUX
admet-2861	367	12	serve	serve	VERB
admet-2861	367	13	as	as	ADP
admet-2861	367	14	a	a	DET
admet-2861	367	15	first	first	ADJ
admet-2861	367	16	step	step	NOUN
admet-2861	367	17	toward	toward	ADP
admet-2861	367	18	a	a	DET
admet-2861	367	19	generally	generally	ADV
admet-2861	367	20	accepted	accept	VERB
admet-2861	367	21	methodology	methodology	NOUN
admet-2861	367	22	for	for	ADP
admet-2861	367	23	conducting	conduct	VERB
admet-2861	367	24	dissolution	dissolution	NOUN
admet-2861	367	25	testing	testing	NOUN
admet-2861	367	26	of	of	ADP
admet-2861	367	27	inhalation	inhalation	NOUN
admet-2861	367	28	products	product	NOUN
admet-2861	367	29	.	.	PUNCT
admet-2861	368	1	funding	funding	NOUN
admet-2861	368	2	:	:	PUNCT
admet-2861	368	3	this	this	DET
admet-2861	368	4	research	research	NOUN
admet-2861	368	5	received	receive	VERB
admet-2861	368	6	no	no	DET
admet-2861	368	7	specific	specific	ADJ
admet-2861	368	8	grant	grant	NOUN
admet-2861	368	9	from	from	ADP
admet-2861	368	10	any	any	DET
admet-2861	368	11	funding	funding	NOUN
admet-2861	368	12	agency	agency	NOUN
admet-2861	368	13	in	in	ADP
admet-2861	368	14	the	the	DET
admet-2861	368	15	public	public	ADJ
admet-2861	368	16	,	,	PUNCT
admet-2861	368	17	private	private	ADJ
admet-2861	368	18	,	,	PUNCT
admet-2861	368	19	or	or	CCONJ
admet-2861	368	20	not	not	PART
admet-2861	368	21	-	-	PUNCT
admet-2861	368	22	forprofit	forprofit	NOUN
admet-2861	368	23	sectors	sector	NOUN
admet-2861	368	24	.	.	PUNCT
admet-2861	369	1	references	reference	NOUN
admet-2861	369	2	[	[	X
admet-2861	369	3	1	1	NUM
admet-2861	369	4	]	]	X
admet-2861	369	5	european	european	PROPN
admet-2861	369	6	medicines	medicine	NOUN
admet-2861	369	7	agency	agency	NOUN
admet-2861	369	8	.	.	PUNCT
admet-2861	370	1	guideline	guideline	NOUN
admet-2861	370	2	on	on	ADP
admet-2861	370	3	the	the	DET
admet-2861	370	4	pharmaceutical	pharmaceutical	ADJ
admet-2861	370	5	quality	quality	NOUN
admet-2861	370	6	of	of	ADP
admet-2861	370	7	inhalation	inhalation	NOUN
admet-2861	370	8	and	and	CCONJ
admet-2861	370	9	nasal	nasal	NOUN
admet-2861	370	10	products	product	NOUN
admet-2861	370	11	.	.	PUNCT
admet-2861	371	1	european	european	ADJ
admet-2861	371	2	medicines	medicines	PROPN
admet-2861	371	3	agency	agency	PROPN
admet-2861	371	4	,	,	PUNCT
admet-2861	371	5	london	london	PROPN
admet-2861	371	6	,	,	PUNCT
admet-2861	371	7	2006	2006	NUM
admet-2861	371	8	.	.	PUNCT
admet-2861	372	1	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-qualityinhalation-and-nasal-products_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-qualityinhalation-and-nasal-products_en.pdf	NOUN
admet-2861	372	2	(	(	PUNCT
admet-2861	372	3	accessed	access	VERB
admet-2861	372	4	:	:	PUNCT
admet-2861	372	5	28.04.2025	28.04.2025	NUM
admet-2861	372	6	.	.	PUNCT
admet-2861	372	7	)	)	PUNCT
admet-2861	373	1	[	[	X
admet-2861	373	2	2	2	NUM
admet-2861	373	3	]	]	X
admet-2861	373	4	council	council	NOUN
admet-2861	373	5	of	of	ADP
admet-2861	373	6	europe	europe	PROPN
admet-2861	373	7	,	,	PUNCT
admet-2861	373	8	european	european	ADJ
admet-2861	373	9	pharmacopoeia	pharmacopoeia	NOUN
admet-2861	373	10	,	,	PUNCT
admet-2861	373	11	11	11	NUM
admet-2861	373	12	ed	ed	NOUN
admet-2861	373	13	.	.	PUNCT
admet-2861	373	14	,	,	PUNCT
admet-2861	373	15	council	council	PROPN
admet-2861	373	16	of	of	ADP
admet-2861	373	17	europe	europe	PROPN
admet-2861	373	18	,	,	PUNCT
admet-2861	373	19	strasbourg	strasbourg	NOUN
admet-2861	373	20	,	,	PUNCT
admet-2861	373	21	2022	2022	NUM
admet-2861	373	22	.	.	PUNCT
admet-2861	374	1	https://www.edqm.eu/en/european-pharmacopoeia-ph.-eur.-11th-edition	https://www.edqm.eu/en/european-pharmacopoeia-ph.-eur.-11th-edition	NOUN
admet-2861	375	1	[	[	X
admet-2861	375	2	3	3	NUM
admet-2861	375	3	]	]	X
admet-2861	375	4	european	european	PROPN
admet-2861	375	5	medicines	medicine	NOUN
admet-2861	375	6	agency	agency	NOUN
admet-2861	375	7	.	.	PUNCT
admet-2861	376	1	guideline	guideline	NOUN
admet-2861	376	2	on	on	ADP
admet-2861	376	3	the	the	DET
admet-2861	376	4	pharmaceutical	pharmaceutical	ADJ
admet-2861	376	5	quality	quality	NOUN
admet-2861	376	6	of	of	ADP
admet-2861	376	7	inhalation	inhalation	NOUN
admet-2861	376	8	and	and	CCONJ
admet-2861	376	9	nasal	nasal	NOUN
admet-2861	376	10	medicinal	medicinal	ADJ
admet-2861	376	11	products	product	NOUN
admet-2861	376	12	draft	draft	NOUN
admet-2861	376	13	.	.	PUNCT
admet-2861	377	1	amsterdam	amsterdam	PROPN
admet-2861	377	2	,	,	PUNCT
admet-2861	377	3	2024	2024	NUM
admet-2861	377	4	.	.	PUNCT
admet-2861	378	1	https://www.ema.europa.eu/en/documents/scientificguideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision1_en.pdf	https://www.ema.europa.eu/en/documents/scientificguideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision1_en.pdf	NOUN
admet-2861	378	2	(	(	PUNCT
admet-2861	378	3	accessed	access	VERB
admet-2861	378	4	:	:	PUNCT
admet-2861	378	5	28.04.2025	28.04.2025	NUM
admet-2861	378	6	.	.	PUNCT
admet-2861	378	7	)	)	PUNCT
admet-2861	379	1	[	[	X
admet-2861	379	2	4	4	X
admet-2861	379	3	]	]	X
admet-2861	379	4	v.	v.	CCONJ
admet-2861	379	5	gray	gray	ADJ
admet-2861	379	6	,	,	PUNCT
admet-2861	379	7	a.	a.	PROPN
admet-2861	379	8	hickey	hickey	PROPN
admet-2861	379	9	,	,	PUNCT
admet-2861	379	10	p.	p.	PROPN
admet-2861	379	11	balmer	balmer	PROPN
admet-2861	379	12	,	,	PUNCT
admet-2861	379	13	n.	n.	NOUN
admet-2861	379	14	davies	davy	NOUN
admet-2861	379	15	,	,	PUNCT
admet-2861	379	16	c.	c.	PROPN
admet-2861	379	17	dunbar	dunbar	PROPN
admet-2861	379	18	,	,	PUNCT
admet-2861	379	19	t.	t.	PROPN
admet-2861	379	20	foster	foster	PROPN
admet-2861	379	21	,	,	PUNCT
admet-2861	379	22	b.	b.	PROPN
admet-2861	379	23	olsson	olsson	PROPN
admet-2861	379	24	,	,	PUNCT
admet-2861	379	25	m.	m.	PROPN
admet-2861	379	26	sakagami	sakagami	PROPN
admet-2861	379	27	,	,	PUNCT
admet-2861	379	28	v.	v.	ADP
admet-2861	379	29	shah	shah	PROPN
admet-2861	379	30	,	,	PUNCT
admet-2861	379	31	m.	m.	NOUN
admet-2861	379	32	smurthwaite	smurthwaite	PROPN
admet-2861	379	33	,	,	PUNCT
admet-2861	379	34	j.	j.	PROPN
admet-2861	379	35	veranth	veranth	PROPN
admet-2861	379	36	,	,	PUNCT
admet-2861	379	37	k.	k.	PROPN
admet-2861	379	38	zaidi	zaidi	PROPN
admet-2861	379	39	.	.	PUNCT
admet-2861	380	1	the	the	DET
admet-2861	380	2	inhalation	inhalation	NOUN
admet-2861	380	3	ad	ad	NOUN
admet-2861	380	4	hoc	hoc	X
admet-2861	380	5	advisory	advisory	ADJ
admet-2861	380	6	panel	panel	NOUN
admet-2861	380	7	for	for	ADP
admet-2861	380	8	the	the	DET
admet-2861	380	9	usp	usp	NOUN
admet-2861	380	10	performance	performance	NOUN
admet-2861	380	11	tests	test	NOUN
admet-2861	380	12	of	of	ADP
admet-2861	380	13	inhalation	inhalation	NOUN
admet-2861	380	14	dosage	dosage	NOUN
admet-2861	380	15	forms	form	NOUN
admet-2861	380	16	.	.	PUNCT
admet-2861	381	1	pharmacopeial	pharmacopeial	ADJ
admet-2861	381	2	forum	forum	NOUN
admet-2861	381	3	34(4	34(4	NOUN
admet-2861	381	4	)	)	PUNCT
admet-2861	381	5	(	(	PUNCT
admet-2861	381	6	2008	2008	NUM
admet-2861	381	7	)	)	PUNCT
admet-2861	381	8	1068	1068	NUM
admet-2861	381	9	-	-	SYM
admet-2861	381	10	1074	1074	NUM
admet-2861	381	11	.	.	PUNCT
admet-2861	382	1	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for	ADP
admet-2861	382	2	_	_	PRON
admet-2861	382	3	the_usp_performance_tests_of_inhalation_dosage_forms	the_usp_performance_tests_of_inhalation_dosage_forms	NUM
admet-2861	382	4	[	[	X
admet-2861	382	5	5	5	NUM
admet-2861	382	6	]	]	SYM
admet-2861	382	7	food	food	NOUN
admet-2861	382	8	and	and	CCONJ
admet-2861	382	9	drug	drug	NOUN
admet-2861	382	10	administration	administration	NOUN
admet-2861	382	11	.	.	PUNCT
admet-2861	383	1	draft	draft	NOUN
admet-2861	383	2	guidance	guidance	NOUN
admet-2861	383	3	on	on	ADP
admet-2861	383	4	budesonide	budesonide	NOUN
admet-2861	383	5	;	;	PUNCT
admet-2861	383	6	formoterol	formoterol	PROPN
admet-2861	383	7	fumatare	fumatare	PROPN
admet-2861	383	8	dihydrate	dihydrate	PROPN
admet-2861	383	9	2024	2024	NUM
admet-2861	383	10	.	.	PUNCT
admet-2861	384	1	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021929.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021929.pdf	NOUN
admet-2861	384	2	(	(	PUNCT
admet-2861	384	3	accessed	access	VERB
admet-2861	384	4	:	:	PUNCT
admet-2861	384	5	28.04.2025	28.04.2025	NUM
admet-2861	384	6	.	.	PUNCT
admet-2861	384	7	)	)	PUNCT
admet-2861	385	1	[	[	X
admet-2861	385	2	6	6	NUM
admet-2861	385	3	]	]	SYM
admet-2861	385	4	food	food	NOUN
admet-2861	385	5	and	and	CCONJ
admet-2861	385	6	drug	drug	NOUN
admet-2861	385	7	administration	administration	NOUN
admet-2861	385	8	.	.	PUNCT
admet-2861	386	1	draft	draft	NOUN
admet-2861	386	2	guidance	guidance	NOUN
admet-2861	386	3	on	on	ADP
admet-2861	386	4	fluticasone	fluticasone	NOUN
admet-2861	386	5	propionate	propionate	NOUN
admet-2861	386	6	2024	2024	NUM
admet-2861	386	7	.	.	PUNCT
admet-2861	387	1	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021433.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021433.pdf	PROPN
admet-2861	387	2	(	(	PUNCT
admet-2861	387	3	accessed	access	VERB
admet-2861	387	4	:	:	PUNCT
admet-2861	387	5	028.04.2025	028.04.2025	NUM
admet-2861	387	6	.	.	PUNCT
admet-2861	387	7	)	)	PUNCT
admet-2861	388	1	[	[	X
admet-2861	388	2	7	7	NUM
admet-2861	388	3	]	]	PUNCT
admet-2861	388	4	a.	a.	NOUN
admet-2861	388	5	nokhodchi	nokhodchi	PROPN
admet-2861	388	6	,	,	PUNCT
admet-2861	388	7	s.	s.	PROPN
admet-2861	388	8	chavan	chavan	PROPN
admet-2861	388	9	,	,	PUNCT
admet-2861	388	10	t.	t.	NOUN
admet-2861	388	11	ghafourian	ghafourian	NOUN
admet-2861	388	12	.	.	PUNCT
admet-2861	389	1	in	in	ADP
admet-2861	389	2	vitro	vitro	X
admet-2861	389	3	dissolution	dissolution	NOUN
admet-2861	389	4	and	and	CCONJ
admet-2861	389	5	permeability	permeability	NOUN
admet-2861	389	6	testing	testing	NOUN
admet-2861	389	7	of	of	ADP
admet-2861	389	8	inhalation	inhalation	NOUN
admet-2861	389	9	products	product	NOUN
admet-2861	389	10	:	:	PUNCT
admet-2861	389	11	challenges	challenge	NOUN
admet-2861	389	12	and	and	CCONJ
admet-2861	389	13	advances	advance	NOUN
admet-2861	389	14	.	.	PUNCT
admet-2861	390	1	pharmaceutics	pharmaceutic	NOUN
admet-2861	390	2	15(3	15(3	NUM
admet-2861	390	3	)	)	PUNCT
admet-2861	390	4	(	(	PUNCT
admet-2861	390	5	2023	2023	NUM
admet-2861	390	6	)	)	PUNCT
admet-2861	390	7	983	983	NUM
admet-2861	390	8	.	.	PUNCT
admet-2861	391	1	https://doi.org/10.3390/pharmaceutics15030983	https://doi.org/10.3390/pharmaceutics15030983	NOUN
admet-2861	392	1	[	[	X
admet-2861	392	2	8	8	NUM
admet-2861	392	3	]	]	X
admet-2861	392	4	b.b	b.b	PROPN
admet-2861	392	5	.	.	PROPN
admet-2861	392	6	eedara	eedara	PROPN
admet-2861	392	7	,	,	PUNCT
admet-2861	392	8	r.	r.	PROPN
admet-2861	392	9	bastola	bastola	PROPN
admet-2861	392	10	,	,	PUNCT
admet-2861	392	11	s.c	s.c	PROPN
admet-2861	392	12	.	.	PUNCT
admet-2861	392	13	das	das	PROPN
admet-2861	392	14	.	.	PUNCT
admet-2861	392	15	dissolution	dissolution	NOUN
admet-2861	392	16	and	and	CCONJ
admet-2861	392	17	absorption	absorption	NOUN
admet-2861	392	18	of	of	ADP
admet-2861	392	19	inhaled	inhaled	ADJ
admet-2861	392	20	drug	drug	NOUN
admet-2861	392	21	particles	particle	NOUN
admet-2861	392	22	in	in	ADP
admet-2861	392	23	the	the	DET
admet-2861	392	24	lungs	lung	NOUN
admet-2861	392	25	.	.	PUNCT
admet-2861	393	1	pharmaceutics	pharmaceutic	NOUN
admet-2861	393	2	14(12	14(12	NUM
admet-2861	393	3	)	)	PUNCT
admet-2861	393	4	(	(	PUNCT
admet-2861	393	5	2022	2022	NUM
admet-2861	393	6	)	)	PUNCT
admet-2861	393	7	2667	2667	NUM
admet-2861	393	8	.	.	PUNCT
admet-2861	394	1	https://doi.org/10.3390/pharmaceutics14122667	https://doi.org/10.3390/pharmaceutics14122667	NOUN
admet-2861	395	1	[	[	X
admet-2861	395	2	9	9	NUM
admet-2861	395	3	]	]	PUNCT
admet-2861	395	4	y.-j	y.-j	PROPN
admet-2861	395	5	.	.	PROPN
admet-2861	395	6	son	son	PROPN
admet-2861	395	7	,	,	PUNCT
admet-2861	395	8	m.	m.	NOUN
admet-2861	395	9	horng	horng	PROPN
admet-2861	395	10	,	,	PUNCT
admet-2861	395	11	m.	m.	NOUN
admet-2861	395	12	copley	copley	PROPN
admet-2861	395	13	,	,	PUNCT
admet-2861	395	14	j.t	j.t	PROPN
admet-2861	395	15	.	.	PROPN
admet-2861	395	16	mcconville	mcconville	PROPN
admet-2861	395	17	.	.	PUNCT
admet-2861	396	1	optimization	optimization	NOUN
admet-2861	396	2	of	of	ADP
admet-2861	396	3	an	an	DET
admet-2861	396	4	in	in	ADP
admet-2861	396	5	vitro	vitro	X
admet-2861	396	6	dissolution	dissolution	NOUN
admet-2861	396	7	test	test	NOUN
admet-2861	396	8	method	method	NOUN
admet-2861	396	9	for	for	ADP
admet-2861	396	10	inhalation	inhalation	NOUN
admet-2861	396	11	formulations	formulation	NOUN
admet-2861	396	12	.	.	PUNCT
admet-2861	397	1	dissolution	dissolution	PROPN
admet-2861	397	2	technologies	technology	NOUN
admet-2861	397	3	17	17	NUM
admet-2861	397	4	(	(	PUNCT
admet-2861	397	5	2010	2010	NUM
admet-2861	397	6	)	)	PUNCT
admet-2861	397	7	6	6	NUM
admet-2861	397	8	-	-	SYM
admet-2861	397	9	13	13	NUM
admet-2861	397	10	.	.	PUNCT
admet-2861	397	11	https://doi.org/10.14227/dt170210p6	https://doi.org/10.14227/dt170210p6	NOUN
admet-2861	398	1	[	[	X
admet-2861	398	2	10	10	NUM
admet-2861	398	3	]	]	X
admet-2861	398	4	r.o	r.o	PROPN
admet-2861	398	5	.	.	PROPN
admet-2861	398	6	cook	cook	PROPN
admet-2861	398	7	,	,	PUNCT
admet-2861	398	8	r.k	r.k	PROPN
admet-2861	398	9	.	.	PROPN
admet-2861	398	10	pannu	pannu	PROPN
admet-2861	398	11	,	,	PUNCT
admet-2861	398	12	i.w	i.w	PROPN
admet-2861	398	13	.	.	PROPN
admet-2861	398	14	kellaway	kellaway	PROPN
admet-2861	398	15	.	.	PUNCT
admet-2861	399	1	novel	novel	ADJ
admet-2861	399	2	sustained	sustain	VERB
admet-2861	399	3	release	release	NOUN
admet-2861	399	4	microspheres	microsphere	NOUN
admet-2861	399	5	for	for	ADP
admet-2861	399	6	pulmonary	pulmonary	ADJ
admet-2861	399	7	drug	drug	NOUN
admet-2861	399	8	delivery	delivery	NOUN
admet-2861	399	9	.	.	PUNCT
admet-2861	400	1	journal	journal	PROPN
admet-2861	400	2	of	of	ADP
admet-2861	400	3	control	control	NOUN
admet-2861	400	4	release	release	NOUN
admet-2861	400	5	104	104	NUM
admet-2861	400	6	(	(	PUNCT
admet-2861	400	7	2005	2005	NUM
admet-2861	400	8	)	)	PUNCT
admet-2861	400	9	79	79	NUM
admet-2861	400	10	-	-	SYM
admet-2861	400	11	90	90	NUM
admet-2861	400	12	.	.	PUNCT
admet-2861	401	1	https://doi.org/10.1016/j.jconrel.2005.01.003	https://doi.org/10.1016/j.jconrel.2005.01.003	PROPN
admet-2861	401	2	[	[	X
admet-2861	401	3	11	11	NUM
admet-2861	401	4	]	]	X
admet-2861	401	5	r.o	r.o	PROPN
admet-2861	401	6	.	.	PROPN
admet-2861	401	7	salama	salama	PROPN
admet-2861	401	8	,	,	PUNCT
admet-2861	401	9	d.	d.	PROPN
admet-2861	401	10	traini	traini	PROPN
admet-2861	401	11	,	,	PUNCT
admet-2861	401	12	h.k	h.k	PROPN
admet-2861	401	13	.	.	PROPN
admet-2861	401	14	chan	chan	PROPN
admet-2861	401	15	,	,	PUNCT
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admet-2861	401	17	sung	sung	PROPN
admet-2861	401	18	,	,	PUNCT
admet-2861	401	19	a.j	a.j	PROPN
admet-2861	401	20	.	.	PROPN
admet-2861	401	21	ammit	ammit	PROPN
admet-2861	401	22	,	,	PUNCT
admet-2861	401	23	p.m.	p.m.	NOUN
admet-2861	401	24	young	young	ADJ
admet-2861	401	25	.	.	PUNCT
admet-2861	402	1	preparation	preparation	NOUN
admet-2861	402	2	and	and	CCONJ
admet-2861	402	3	evaluation	evaluation	NOUN
admet-2861	402	4	of	of	ADP
admet-2861	402	5	controlled	control	VERB
admet-2861	402	6	release	release	NOUN
admet-2861	402	7	microparticles	microparticle	NOUN
admet-2861	402	8	for	for	ADP
admet-2861	402	9	respiratory	respiratory	ADJ
admet-2861	402	10	protein	protein	NOUN
admet-2861	402	11	therapy	therapy	NOUN
admet-2861	402	12	.	.	PUNCT
admet-2861	403	1	journal	journal	PROPN
admet-2861	403	2	of	of	ADP
admet-2861	403	3	pharmaceutical	pharmaceutical	ADJ
admet-2861	403	4	sciences	science	NOUN
admet-2861	403	5	98	98	NUM
admet-2861	403	6	(	(	PUNCT
admet-2861	403	7	2009	2009	NUM
admet-2861	403	8	)	)	PUNCT
admet-2861	403	9	2709	2709	NUM
admet-2861	403	10	-	-	SYM
admet-2861	403	11	2717	2717	NUM
admet-2861	403	12	.	.	PUNCT
admet-2861	404	1	https://doi.org/10.1002/jps.21653	https://doi.org/10.1002/jps.21653	PROPN
admet-2861	404	2	.	.	PUNCT
admet-2861	404	3	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-quality-inhalation-and-nasal-products_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-quality-inhalation-and-nasal-products_en.pdf	PROPN
admet-2861	404	4	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-quality-inhalation-and-nasal-products_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-quality-inhalation-and-nasal-products_en.pdf	PROPN
admet-2861	404	5	https://www.edqm.eu/en/european-pharmacopoeia-ph.-eur.-11th-edition	https://www.edqm.eu/en/european-pharmacopoeia-ph.-eur.-11th-edition	PROPN
admet-2861	404	6	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	PROPN
admet-2861	404	7	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	NOUN
admet-2861	404	8	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-pharmaceutical-quality-inhalation-nasal-medicinal-products-revision-1_en.pdf	NOUN
admet-2861	404	9	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for_the_usp_performance_tests_of_inhalation_dosage_forms	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for_the_usp_performance_tests_of_inhalation_dosage_form	NOUN
admet-2861	404	10	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for_the_usp_performance_tests_of_inhalation_dosage_forms	https://www.researchgate.net/publication/237379078_the_inhalation_ad_hoc_advisory_panel_for_the_usp_performance_tests_of_inhalation_dosage_form	NOUN
admet-2861	404	11	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021929.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021929.pdf	PROPN
admet-2861	404	12	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021433.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/psg/psg_021433.pdf	PROPN
admet-2861	404	13	https://doi.org/10.3390/pharmaceutics15030983	https://doi.org/10.3390/pharmaceutics15030983	PROPN
admet-2861	404	14	https://doi.org/10.3390/pharmaceutics14122667	https://doi.org/10.3390/pharmaceutics14122667	NOUN
admet-2861	404	15	https://doi.org/10.14227/dt170210p6	https://doi.org/10.14227/dt170210p6	NOUN
admet-2861	404	16	https://doi.org/10.1016/j.jconrel.2005.01.003	https://doi.org/10.1016/j.jconrel.2005.01.003	VERB
admet-2861	404	17	https://doi.org/10.1002/jps.21653	https://doi.org/10.1002/jps.21653	PROPN
admet-2861	404	18	admet	admet	PROPN
admet-2861	404	19	&	&	CCONJ
admet-2861	404	20	dmpk	dmpk	PROPN
admet-2861	404	21	13	13	NUM
admet-2861	404	22	(	(	PUNCT
admet-2861	404	23	)	)	PUNCT
admet-2861	404	24	(	(	PUNCT
admet-2861	404	25	2025	2025	NUM
admet-2861	404	26	)	)	PUNCT
admet-2861	404	27	2861	2861	NUM
admet-2861	404	28	development	development	NOUN
admet-2861	404	29	of	of	ADP
admet-2861	404	30	a	a	DET
admet-2861	404	31	biorelevant	biorelevant	ADJ
admet-2861	404	32	dissolution	dissolution	NOUN
admet-2861	404	33	method	method	NOUN
admet-2861	404	34	for	for	ADP
admet-2861	404	35	inhalation	inhalation	NOUN
admet-2861	404	36	products	product	NOUN
admet-2861	404	37	doi	doi	NOUN
admet-2861	404	38	:	:	PUNCT
admet-2861	404	39	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	404	40	21	21	NUM
admet-2861	405	1	[	[	X
admet-2861	405	2	12	12	NUM
admet-2861	405	3	]	]	X
admet-2861	405	4	f.	f.	PROPN
admet-2861	405	5	sonvico	sonvico	PROPN
admet-2861	405	6	,	,	PUNCT
admet-2861	405	7	v.	v.	ADP
admet-2861	405	8	chierici	chierici	NOUN
admet-2861	405	9	,	,	PUNCT
admet-2861	405	10	g.	g.	PROPN
admet-2861	405	11	varacca	varacca	PROPN
admet-2861	405	12	,	,	PUNCT
admet-2861	405	13	e.	e.	PROPN
admet-2861	405	14	quarta	quarta	PROPN
admet-2861	405	15	,	,	PUNCT
admet-2861	405	16	d.	d.	PROPN
admet-2861	405	17	d'angelo	d'angelo	PROPN
admet-2861	405	18	,	,	PUNCT
admet-2861	405	19	b.	b.	PROPN
admet-2861	405	20	forbes	forbes	PROPN
admet-2861	405	21	,	,	PUNCT
admet-2861	405	22	f.	f.	PROPN
admet-2861	405	23	buttini	buttini	PROPN
admet-2861	405	24	.	.	PUNCT
admet-2861	406	1	respicell(tm	respicell(tm	NOUN
admet-2861	406	2	):	):	PUNCT
admet-2861	406	3	an	an	DET
admet-2861	406	4	innovative	innovative	ADJ
admet-2861	406	5	dissolution	dissolution	NOUN
admet-2861	406	6	apparatus	apparatus	NOUN
admet-2861	406	7	for	for	ADP
admet-2861	406	8	inhaled	inhaled	ADJ
admet-2861	406	9	products	product	NOUN
admet-2861	406	10	.	.	PUNCT
admet-2861	407	1	pharmaceutics	pharmaceutic	NOUN
admet-2861	407	2	13(10	13(10	NUM
admet-2861	407	3	)	)	PUNCT
admet-2861	407	4	(	(	PUNCT
admet-2861	407	5	2021	2021	NUM
admet-2861	407	6	)	)	PUNCT
admet-2861	407	7	.	.	PUNCT
admet-2861	408	1	1541	1541	NUM
admet-2861	408	2	.	.	PUNCT
admet-2861	409	1	https://doi.org/10.3390/pharmaceutics13101541	https://doi.org/10.3390/pharmaceutics13101541	X
admet-2861	409	2	.	.	PUNCT
admet-2861	410	1	[	[	X
admet-2861	410	2	13	13	NUM
admet-2861	410	3	]	]	PUNCT
admet-2861	410	4	v.	v.	CCONJ
admet-2861	410	5	patterlini	patterlini	PROPN
admet-2861	410	6	,	,	PUNCT
admet-2861	410	7	f.	f.	PROPN
admet-2861	410	8	guareschi	guareschi	PROPN
admet-2861	410	9	,	,	PUNCT
admet-2861	410	10	d.	d.	PROPN
admet-2861	410	11	d’angelo	d’angelo	PROPN
admet-2861	410	12	,	,	PUNCT
admet-2861	410	13	s.	s.	PROPN
admet-2861	410	14	baldini	baldini	PROPN
admet-2861	410	15	,	,	PUNCT
admet-2861	410	16	s.	s.	PROPN
admet-2861	410	17	meto	meto	PROPN
admet-2861	410	18	,	,	PUNCT
admet-2861	410	19	d.	d.	PROPN
admet-2861	410	20	mostafa	mostafa	PROPN
admet-2861	410	21	kamal	kamal	PROPN
admet-2861	410	22	,	,	PUNCT
admet-2861	410	23	p.	p.	PROPN
admet-2861	410	24	fabrizzi	fabrizzi	PROPN
admet-2861	410	25	,	,	PUNCT
admet-2861	410	26	f.	f.	PROPN
admet-2861	410	27	buttini	buttini	PROPN
admet-2861	410	28	,	,	PUNCT
admet-2861	410	29	r.	r.	PROPN
admet-2861	410	30	mösges	mösge	NOUN
admet-2861	410	31	,	,	PUNCT
admet-2861	410	32	f.	f.	PROPN
admet-2861	410	33	sonvico	sonvico	PROPN
admet-2861	410	34	.	.	PUNCT
admet-2861	411	1	clinically	clinically	ADV
admet-2861	411	2	relevant	relevant	ADJ
admet-2861	411	3	characterization	characterization	NOUN
admet-2861	411	4	and	and	CCONJ
admet-2861	411	5	comparison	comparison	NOUN
admet-2861	411	6	of	of	ADP
admet-2861	411	7	ryaltris	ryaltris	NOUN
admet-2861	411	8	and	and	CCONJ
admet-2861	411	9	other	other	ADJ
admet-2861	411	10	antiallergic	antiallergic	PROPN
admet-2861	411	11	nasal	nasal	PROPN
admet-2861	411	12	sprays	spray	NOUN
admet-2861	411	13	.	.	PUNCT
admet-2861	412	1	pharmaceutics	pharmaceutic	NOUN
admet-2861	412	2	16	16	NUM
admet-2861	412	3	(	(	PUNCT
admet-2861	412	4	2024	2024	NUM
admet-2861	412	5	)	)	PUNCT
admet-2861	412	6	989	989	NUM
admet-2861	412	7	.	.	PUNCT
admet-2861	412	8	https://www.mdpi.com/1999-4923/16/8/989	https://www.mdpi.com/1999-4923/16/8/989	PROPN
admet-2861	412	9	.	.	PUNCT
admet-2861	413	1	[	[	X
admet-2861	413	2	14	14	NUM
admet-2861	413	3	]	]	PUNCT
admet-2861	413	4	m.	m.	NOUN
admet-2861	413	5	rohrschneider	rohrschneider	NOUN
admet-2861	413	6	,	,	PUNCT
admet-2861	413	7	s.	s.	PROPN
admet-2861	413	8	bhagwat	bhagwat	PROPN
admet-2861	413	9	,	,	PUNCT
admet-2861	413	10	r.	r.	PROPN
admet-2861	413	11	krampe	krampe	PROPN
admet-2861	413	12	,	,	PUNCT
admet-2861	413	13	v.	v.	ADP
admet-2861	413	14	michler	michler	NOUN
admet-2861	413	15	,	,	PUNCT
admet-2861	413	16	j.	j.	PROPN
admet-2861	413	17	breitkreutz	breitkreutz	PROPN
admet-2861	413	18	,	,	PUNCT
admet-2861	413	19	g.	g.	PROPN
admet-2861	413	20	hochhaus	hochhaus	PROPN
admet-2861	413	21	.	.	PUNCT
admet-2861	414	1	evaluation	evaluation	NOUN
admet-2861	414	2	of	of	ADP
admet-2861	414	3	the	the	DET
admet-2861	414	4	transwell	transwell	NOUN
admet-2861	414	5	system	system	NOUN
admet-2861	414	6	for	for	ADP
admet-2861	414	7	characterization	characterization	NOUN
admet-2861	414	8	of	of	ADP
admet-2861	414	9	dissolution	dissolution	ADJ
admet-2861	414	10	behavior	behavior	NOUN
admet-2861	414	11	of	of	ADP
admet-2861	414	12	inhalation	inhalation	NOUN
admet-2861	414	13	drugs	drug	NOUN
admet-2861	414	14	:	:	PUNCT
admet-2861	414	15	effects	effect	NOUN
admet-2861	414	16	of	of	ADP
admet-2861	414	17	membrane	membrane	NOUN
admet-2861	414	18	and	and	CCONJ
admet-2861	414	19	surfactant	surfactant	NOUN
admet-2861	414	20	.	.	PUNCT
admet-2861	415	1	molecular	molecular	ADJ
admet-2861	415	2	pharmaceutics	pharmaceutic	NOUN
admet-2861	415	3	12	12	NUM
admet-2861	415	4	(	(	PUNCT
admet-2861	415	5	2015	2015	NUM
admet-2861	415	6	)	)	PUNCT
admet-2861	415	7	2618	2618	NUM
admet-2861	415	8	-	-	SYM
admet-2861	415	9	2624	2624	NUM
admet-2861	415	10	.	.	PUNCT
admet-2861	416	1	https://doi.org/10.1021/acs.molpharmaceut.5b00221	https://doi.org/10.1021/acs.molpharmaceut.5b00221	NOUN
admet-2861	416	2	.	.	PUNCT
admet-2861	417	1	[	[	X
admet-2861	417	2	15	15	NUM
admet-2861	417	3	]	]	X
admet-2861	417	4	d.	d.	PROPN
admet-2861	417	5	arora	arora	PROPN
admet-2861	417	6	,	,	PUNCT
admet-2861	417	7	k.a	k.a	PROPN
admet-2861	417	8	.	.	PROPN
admet-2861	417	9	shah	shah	PROPN
admet-2861	417	10	,	,	PUNCT
admet-2861	417	11	m.s	m.s	PROPN
admet-2861	417	12	.	.	PROPN
admet-2861	417	13	halquist	halquist	PROPN
admet-2861	417	14	,	,	PUNCT
admet-2861	417	15	m.	m.	PROPN
admet-2861	417	16	sakagami	sakagami	PROPN
admet-2861	417	17	.	.	PUNCT
admet-2861	418	1	in	in	ADP
admet-2861	418	2	vitro	vitro	X
admet-2861	418	3	aqueous	aqueous	ADJ
admet-2861	418	4	fluid	fluid	NOUN
admet-2861	418	5	-	-	PUNCT
admet-2861	418	6	capacity	capacity	NOUN
admet-2861	418	7	-	-	PUNCT
admet-2861	418	8	limited	limit	VERB
admet-2861	418	9	dissolution	dissolution	NOUN
admet-2861	418	10	testing	testing	NOUN
admet-2861	418	11	of	of	ADP
admet-2861	418	12	respirable	respirable	ADJ
admet-2861	418	13	aerosol	aerosol	NOUN
admet-2861	418	14	drug	drug	NOUN
admet-2861	418	15	particles	particle	NOUN
admet-2861	418	16	generated	generate	VERB
admet-2861	418	17	from	from	ADP
admet-2861	418	18	inhaler	inhaler	NOUN
admet-2861	418	19	products	product	NOUN
admet-2861	418	20	.	.	PUNCT
admet-2861	419	1	pharmaceutical	pharmaceutical	NOUN
admet-2861	419	2	research	research	NOUN
admet-2861	419	3	27	27	NUM
admet-2861	419	4	(	(	PUNCT
admet-2861	419	5	2010	2010	NUM
admet-2861	419	6	)	)	PUNCT
admet-2861	419	7	786	786	NUM
admet-2861	419	8	-	-	SYM
admet-2861	419	9	795	795	NUM
admet-2861	419	10	.	.	PUNCT
admet-2861	420	1	https://doi.org/10.1007/s11095-010-0070-5	https://doi.org/10.1007/s11095-010-0070-5	NUM
admet-2861	420	2	.	.	PUNCT
admet-2861	421	1	[	[	X
admet-2861	421	2	16	16	NUM
admet-2861	421	3	]	]	X
admet-2861	421	4	f.	f.	PROPN
admet-2861	421	5	franek	franek	PROPN
admet-2861	421	6	,	,	PUNCT
admet-2861	421	7	r.	r.	PROPN
admet-2861	421	8	fransson	fransson	PROPN
admet-2861	421	9	,	,	PUNCT
admet-2861	421	10	h.	h.	PROPN
admet-2861	421	11	thörn	thörn	PROPN
admet-2861	421	12	,	,	PUNCT
admet-2861	421	13	p.	p.	PROPN
admet-2861	421	14	bäckman	bäckman	PROPN
admet-2861	421	15	,	,	PUNCT
admet-2861	421	16	p.u	p.u	PROPN
admet-2861	421	17	.	.	PROPN
admet-2861	421	18	andersson	andersson	PROPN
admet-2861	421	19	,	,	PUNCT
admet-2861	421	20	u.	u.	PROPN
admet-2861	421	21	tehler	tehler	NOUN
admet-2861	421	22	.	.	PUNCT
admet-2861	422	1	ranking	rank	VERB
admet-2861	422	2	in	in	ADP
admet-2861	422	3	vitro	vitro	X
admet-2861	422	4	dissolution	dissolution	NOUN
admet-2861	422	5	of	of	ADP
admet-2861	422	6	inhaled	inhaled	ADJ
admet-2861	422	7	micronized	micronized	ADJ
admet-2861	422	8	drug	drug	NOUN
admet-2861	422	9	powders	powder	NOUN
admet-2861	422	10	including	include	VERB
admet-2861	422	11	a	a	DET
admet-2861	422	12	candidate	candidate	NOUN
admet-2861	422	13	drug	drug	NOUN
admet-2861	422	14	with	with	ADP
admet-2861	422	15	two	two	NUM
admet-2861	422	16	different	different	ADJ
admet-2861	422	17	particle	particle	NOUN
admet-2861	422	18	sizes	size	NOUN
admet-2861	422	19	.	.	PUNCT
admet-2861	423	1	molecular	molecular	ADJ
admet-2861	423	2	pharmaceutics	pharmaceutic	NOUN
admet-2861	423	3	15	15	NUM
admet-2861	423	4	(	(	PUNCT
admet-2861	423	5	2018	2018	NUM
admet-2861	423	6	)	)	PUNCT
admet-2861	423	7	5319	5319	NUM
admet-2861	423	8	-	-	SYM
admet-2861	423	9	5326	5326	NUM
admet-2861	423	10	.	.	PUNCT
admet-2861	424	1	https://doi.org/10.1021/acs.molpharmaceut.8b00796	https://doi.org/10.1021/acs.molpharmaceut.8b00796	X
admet-2861	424	2	.	.	PUNCT
admet-2861	425	1	[	[	X
admet-2861	425	2	17	17	NUM
admet-2861	425	3	]	]	X
admet-2861	425	4	n.m	n.m	PROPN
admet-2861	425	5	.	.	PROPN
admet-2861	425	6	davies	davy	NOUN
admet-2861	425	7	,	,	PUNCT
admet-2861	425	8	m.r	m.r	PROPN
admet-2861	425	9	.	.	PROPN
admet-2861	425	10	feddah	feddah	PROPN
admet-2861	425	11	.	.	PUNCT
admet-2861	426	1	a	a	DET
admet-2861	426	2	novel	novel	ADJ
admet-2861	426	3	method	method	NOUN
admet-2861	426	4	for	for	ADP
admet-2861	426	5	assessing	assess	VERB
admet-2861	426	6	dissolution	dissolution	NOUN
admet-2861	426	7	of	of	ADP
admet-2861	426	8	aerosol	aerosol	NOUN
admet-2861	426	9	inhaler	inhaler	NOUN
admet-2861	426	10	products	product	NOUN
admet-2861	426	11	.	.	PUNCT
admet-2861	427	1	international	international	ADJ
admet-2861	427	2	journal	journal	PROPN
admet-2861	427	3	of	of	ADP
admet-2861	427	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	427	5	255	255	NUM
admet-2861	427	6	(	(	PUNCT
admet-2861	427	7	2003	2003	NUM
admet-2861	427	8	)	)	PUNCT
admet-2861	427	9	175	175	NUM
admet-2861	427	10	-	-	SYM
admet-2861	427	11	187	187	NUM
admet-2861	427	12	.	.	PUNCT
admet-2861	428	1	https://doi.org/10.1016/s03785173(03)00091-7	https://doi.org/10.1016/s03785173(03)00091-7	PROPN
admet-2861	429	1	[	[	X
admet-2861	429	2	18	18	NUM
admet-2861	429	3	]	]	X
admet-2861	429	4	j.t	j.t	PROPN
admet-2861	429	5	.	.	PROPN
admet-2861	429	6	mcconville	mcconville	PROPN
admet-2861	429	7	,	,	PUNCT
admet-2861	429	8	n.	n.	PROPN
admet-2861	429	9	patel	patel	PROPN
admet-2861	429	10	,	,	PUNCT
admet-2861	429	11	n.	n.	PROPN
admet-2861	429	12	ditchburn	ditchburn	PROPN
admet-2861	429	13	,	,	PUNCT
admet-2861	429	14	m.j	m.j	PROPN
admet-2861	429	15	.	.	PROPN
admet-2861	429	16	tobyn	tobyn	PROPN
admet-2861	429	17	,	,	PUNCT
admet-2861	429	18	j.n	j.n	PROPN
admet-2861	429	19	.	.	PROPN
admet-2861	429	20	staniforth	staniforth	PROPN
admet-2861	429	21	,	,	PUNCT
admet-2861	429	22	p.	p.	NOUN
admet-2861	429	23	woodcock	woodcock	NOUN
admet-2861	429	24	.	.	PUNCT
admet-2861	430	1	use	use	NOUN
admet-2861	430	2	of	of	ADP
admet-2861	430	3	a	a	DET
admet-2861	430	4	novel	novel	NOUN
admet-2861	430	5	modified	modify	VERB
admet-2861	430	6	tsi	tsi	NOUN
admet-2861	430	7	for	for	ADP
admet-2861	430	8	the	the	DET
admet-2861	430	9	evaluation	evaluation	NOUN
admet-2861	430	10	of	of	ADP
admet-2861	430	11	controlled	control	VERB
admet-2861	430	12	-	-	PUNCT
admet-2861	430	13	release	release	NOUN
admet-2861	430	14	aerosol	aerosol	NOUN
admet-2861	430	15	formulations	formulation	NOUN
admet-2861	430	16	.	.	PUNCT
admet-2861	431	1	i.	i.	PROPN
admet-2861	431	2	drug	drug	PROPN
admet-2861	431	3	development	development	PROPN
admet-2861	431	4	and	and	CCONJ
admet-2861	431	5	industrial	industrial	ADJ
admet-2861	431	6	pharmacy	pharmacy	NOUN
admet-2861	431	7	26	26	NUM
admet-2861	431	8	(	(	PUNCT
admet-2861	431	9	2000	2000	NUM
admet-2861	431	10	)	)	PUNCT
admet-2861	431	11	1191	1191	NUM
admet-2861	431	12	-	-	SYM
admet-2861	431	13	1198	1198	NUM
admet-2861	431	14	.	.	PUNCT
admet-2861	432	1	https://doi.org/10.1081/ddc-100100991	https://doi.org/10.1081/ddc-100100991	NOUN
admet-2861	432	2	.	.	PUNCT
admet-2861	433	1	[	[	X
admet-2861	433	2	19	19	NUM
admet-2861	433	3	]	]	PUNCT
admet-2861	433	4	y.-j	y.-j	PROPN
admet-2861	433	5	.	.	PROPN
admet-2861	433	6	son	son	PROPN
admet-2861	433	7	,	,	PUNCT
admet-2861	433	8	j.t	j.t	PROPN
admet-2861	433	9	.	.	PROPN
admet-2861	433	10	mcconville	mcconville	PROPN
admet-2861	433	11	.	.	PUNCT
admet-2861	434	1	development	development	NOUN
admet-2861	434	2	of	of	ADP
admet-2861	434	3	a	a	DET
admet-2861	434	4	standardized	standardized	ADJ
admet-2861	434	5	dissolution	dissolution	NOUN
admet-2861	434	6	test	test	NOUN
admet-2861	434	7	method	method	NOUN
admet-2861	434	8	for	for	ADP
admet-2861	434	9	inhaled	inhaled	ADJ
admet-2861	434	10	pharmaceutical	pharmaceutical	NOUN
admet-2861	434	11	formulations	formulation	NOUN
admet-2861	434	12	.	.	PUNCT
admet-2861	435	1	international	international	ADJ
admet-2861	435	2	journal	journal	PROPN
admet-2861	435	3	of	of	ADP
admet-2861	435	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	435	5	382	382	NUM
admet-2861	435	6	(	(	PUNCT
admet-2861	435	7	2009	2009	NUM
admet-2861	435	8	)	)	PUNCT
admet-2861	435	9	15	15	NUM
admet-2861	435	10	-	-	SYM
admet-2861	435	11	22	22	NUM
admet-2861	435	12	.	.	PUNCT
admet-2861	436	1	https://doi.org/10.1016/j.ijpharm.2009.07.034	https://doi.org/10.1016/j.ijpharm.2009.07.034	PRON
admet-2861	437	1	[	[	X
admet-2861	437	2	20	20	NUM
admet-2861	437	3	]	]	X
admet-2861	438	1	s.	s.	PROPN
admet-2861	438	2	may	may	AUX
admet-2861	438	3	,	,	PUNCT
admet-2861	438	4	b.	b.	PROPN
admet-2861	438	5	jensen	jensen	PROPN
admet-2861	438	6	,	,	PUNCT
admet-2861	438	7	m.	m.	NOUN
admet-2861	438	8	wolkenhauer	wolkenhauer	PROPN
admet-2861	438	9	,	,	PUNCT
admet-2861	438	10	m.	m.	NOUN
admet-2861	438	11	schneider	schneider	PROPN
admet-2861	438	12	,	,	PUNCT
admet-2861	438	13	c.m	c.m	PROPN
admet-2861	438	14	.	.	PROPN
admet-2861	438	15	lehr	lehr	PROPN
admet-2861	438	16	.	.	PUNCT
admet-2861	439	1	dissolution	dissolution	NOUN
admet-2861	439	2	techniques	technique	NOUN
admet-2861	439	3	for	for	ADP
admet-2861	439	4	in	in	X
admet-2861	439	5	vitro	vitro	X
admet-2861	439	6	testing	testing	NOUN
admet-2861	439	7	of	of	ADP
admet-2861	439	8	dry	dry	ADJ
admet-2861	439	9	powders	powder	NOUN
admet-2861	439	10	for	for	ADP
admet-2861	439	11	inhalation	inhalation	NOUN
admet-2861	439	12	.	.	PUNCT
admet-2861	440	1	pharmaceutical	pharmaceutical	ADJ
admet-2861	440	2	research	research	NOUN
admet-2861	440	3	29	29	NUM
admet-2861	440	4	(	(	PUNCT
admet-2861	440	5	2012	2012	NUM
admet-2861	440	6	)	)	PUNCT
admet-2861	440	7	2157	2157	NUM
admet-2861	440	8	-	-	SYM
admet-2861	440	9	2166	2166	NUM
admet-2861	440	10	.	.	PUNCT
admet-2861	441	1	https://doi.org/10.1007/s11095-012-0744-2	https://doi.org/10.1007/s11095-012-0744-2	NOUN
admet-2861	441	2	.	.	PUNCT
admet-2861	442	1	[	[	X
admet-2861	442	2	21	21	NUM
admet-2861	442	3	]	]	X
admet-2861	442	4	p.	p.	NOUN
admet-2861	442	5	gerde	gerde	PROPN
admet-2861	442	6	,	,	PUNCT
admet-2861	442	7	m.	m.	NOUN
admet-2861	442	8	malmlöf	malmlöf	PROPN
admet-2861	442	9	,	,	PUNCT
admet-2861	442	10	l.	l.	PROPN
admet-2861	442	11	havsborn	havsborn	PROPN
admet-2861	442	12	,	,	PUNCT
admet-2861	442	13	c.-o	c.-o	NOUN
admet-2861	442	14	.	.	PUNCT
admet-2861	443	1	sjöberg	sjöberg	PROPN
admet-2861	443	2	,	,	PUNCT
admet-2861	443	3	p.	p.	PROPN
admet-2861	443	4	ewing	ewing	PROPN
admet-2861	443	5	,	,	PUNCT
admet-2861	443	6	s.	s.	PROPN
admet-2861	443	7	eirefelt	eirefelt	PROPN
admet-2861	443	8	,	,	PUNCT
admet-2861	443	9	k.	k.	PROPN
admet-2861	443	10	ekelund	ekelund	PROPN
admet-2861	443	11	.	.	PUNCT
admet-2861	444	1	dissolvit	dissolvit	PROPN
admet-2861	444	2	:	:	PUNCT
admet-2861	444	3	an	an	DET
admet-2861	444	4	in	in	ADP
admet-2861	444	5	vitro	vitro	X
admet-2861	444	6	method	method	NOUN
admet-2861	444	7	for	for	ADP
admet-2861	444	8	simulating	simulate	VERB
admet-2861	444	9	the	the	DET
admet-2861	444	10	dissolution	dissolution	NOUN
admet-2861	444	11	and	and	CCONJ
admet-2861	444	12	absorption	absorption	NOUN
admet-2861	444	13	of	of	ADP
admet-2861	444	14	inhaled	inhaled	ADJ
admet-2861	444	15	dry	dry	ADJ
admet-2861	444	16	powder	powder	NOUN
admet-2861	444	17	drugs	drug	NOUN
admet-2861	444	18	in	in	ADP
admet-2861	444	19	the	the	DET
admet-2861	444	20	lungs	lung	NOUN
admet-2861	444	21	.	.	PUNCT
admet-2861	445	1	assay	assay	NOUN
admet-2861	445	2	and	and	CCONJ
admet-2861	445	3	drug	drug	NOUN
admet-2861	445	4	development	development	NOUN
admet-2861	445	5	technologies	technology	NOUN
admet-2861	445	6	15	15	NUM
admet-2861	445	7	(	(	PUNCT
admet-2861	445	8	2017	2017	NUM
admet-2861	445	9	)	)	PUNCT
admet-2861	445	10	77	77	NUM
admet-2861	445	11	-	-	SYM
admet-2861	445	12	88	88	NUM
admet-2861	445	13	.	.	PUNCT
admet-2861	446	1	https://doi.org/10.1089/adt.2017.779	https://doi.org/10.1089/adt.2017.779	PROPN
admet-2861	446	2	.	.	PUNCT
admet-2861	447	1	[	[	X
admet-2861	447	2	22	22	NUM
admet-2861	447	3	]	]	PUNCT
admet-2861	447	4	inhalation	inhalation	NOUN
admet-2861	447	5	sciences	science	NOUN
admet-2861	447	6	.	.	PUNCT
admet-2861	448	1	disolvit	disolvit	PROPN
admet-2861	448	2	:	:	PUNCT
admet-2861	448	3	in	in	ADP
admet-2861	448	4	vitro	vitro	X
admet-2861	448	5	dissolution	dissolution	PROPN
admet-2861	448	6	,	,	PUNCT
admet-2861	448	7	https://www.inhalation.se/inhalation-researchservices/dissolvit-in-vitro-dissolution/	https://www.inhalation.se/inhalation-researchservices/dissolvit-in-vitro-dissolution/	PROPN
admet-2861	448	8	.	.	PUNCT
admet-2861	449	1	(	(	PUNCT
admet-2861	449	2	accessed	access	VERB
admet-2861	449	3	:	:	PUNCT
admet-2861	449	4	12.06.2022	12.06.2022	NUM
admet-2861	449	5	.	.	PUNCT
admet-2861	449	6	)	)	PUNCT
admet-2861	449	7	.	.	PUNCT
admet-2861	450	1	[	[	X
admet-2861	450	2	23	23	NUM
admet-2861	450	3	]	]	X
admet-2861	450	4	p.	p.	NOUN
admet-2861	450	5	gerde	gerde	PROPN
admet-2861	450	6	,	,	PUNCT
admet-2861	450	7	m.	m.	NOUN
admet-2861	450	8	malmlöf	malmlöf	PROPN
admet-2861	450	9	,	,	PUNCT
admet-2861	450	10	e.	e.	PROPN
admet-2861	450	11	selg	selg	PROPN
admet-2861	450	12	.	.	PUNCT
admet-2861	451	1	in	in	ADP
admet-2861	451	2	vitro	vitro	X
admet-2861	451	3	to	to	ADP
admet-2861	451	4	ex	ex	PRON
admet-2861	451	5	vivo	vivo	NOUN
admet-2861	451	6	/	/	SYM
admet-2861	451	7	in	in	ADP
admet-2861	451	8	vivo	vivo	ADJ
admet-2861	451	9	correlation	correlation	NOUN
admet-2861	451	10	(	(	PUNCT
admet-2861	451	11	ivivc	ivivc	PROPN
admet-2861	451	12	)	)	PUNCT
admet-2861	451	13	of	of	ADP
admet-2861	451	14	dissolution	dissolution	ADJ
admet-2861	451	15	kinetics	kinetic	NOUN
admet-2861	451	16	from	from	ADP
admet-2861	451	17	inhaled	inhaled	ADJ
admet-2861	451	18	particulate	particulate	NOUN
admet-2861	451	19	solutes	solute	NOUN
admet-2861	451	20	using	use	VERB
admet-2861	451	21	air	air	NOUN
admet-2861	451	22	/	/	SYM
admet-2861	451	23	blood	blood	NOUN
admet-2861	451	24	barrier	barrier	NOUN
admet-2861	451	25	models	model	NOUN
admet-2861	451	26	:	:	PUNCT
admet-2861	451	27	relation	relation	NOUN
admet-2861	451	28	between	between	ADP
admet-2861	451	29	in	in	ADP
admet-2861	451	30	vitro	vitro	X
admet-2861	451	31	design	design	NOUN
admet-2861	451	32	,	,	PUNCT
admet-2861	451	33	lung	lung	NOUN
admet-2861	451	34	physiology	physiology	NOUN
admet-2861	451	35	and	and	CCONJ
admet-2861	451	36	kinetic	kinetic	ADJ
admet-2861	451	37	output	output	NOUN
admet-2861	451	38	of	of	ADP
admet-2861	451	39	models	model	NOUN
admet-2861	451	40	.	.	PUNCT
admet-2861	452	1	journal	journal	NOUN
admet-2861	452	2	of	of	ADP
admet-2861	452	3	aerosol	aerosol	NOUN
admet-2861	452	4	science	science	NOUN
admet-2861	452	5	151	151	NUM
admet-2861	452	6	(	(	PUNCT
admet-2861	452	7	2021	2021	NUM
admet-2861	452	8	)	)	PUNCT
admet-2861	452	9	105698	105698	NUM
admet-2861	452	10	.	.	PUNCT
admet-2861	453	1	https://doi.org/10.1016/j.jaerosci.2020.105698	https://doi.org/10.1016/j.jaerosci.2020.105698	PROPN
admet-2861	453	2	[	[	X
admet-2861	453	3	24	24	NUM
admet-2861	453	4	]	]	SYM
admet-2861	453	5	s.p	s.p	PROPN
admet-2861	453	6	.	.	PROPN
admet-2861	453	7	velaga	velaga	PROPN
admet-2861	453	8	,	,	PUNCT
admet-2861	453	9	j.	j.	PROPN
admet-2861	453	10	djuris	djuris	PROPN
admet-2861	453	11	,	,	PUNCT
admet-2861	453	12	s.	s.	PROPN
admet-2861	453	13	cvijic	cvijic	PROPN
admet-2861	453	14	,	,	PUNCT
admet-2861	453	15	s.	s.	PROPN
admet-2861	453	16	rozou	rozou	PROPN
admet-2861	453	17	,	,	PUNCT
admet-2861	453	18	p.	p.	PROPN
admet-2861	453	19	russo	russo	PROPN
admet-2861	453	20	,	,	PUNCT
admet-2861	453	21	g.	g.	PROPN
admet-2861	453	22	colombo	colombo	PROPN
admet-2861	453	23	,	,	PUNCT
admet-2861	453	24	a.	a.	PROPN
admet-2861	453	25	rossi	rossi	PROPN
admet-2861	453	26	.	.	PUNCT
admet-2861	454	1	dry	dry	ADJ
admet-2861	454	2	powder	powder	NOUN
admet-2861	454	3	inhalers	inhaler	NOUN
admet-2861	454	4	:	:	PUNCT
admet-2861	454	5	an	an	DET
admet-2861	454	6	overview	overview	NOUN
admet-2861	454	7	of	of	ADP
admet-2861	454	8	the	the	DET
admet-2861	454	9	in	in	X
admet-2861	454	10	vitro	vitro	X
admet-2861	454	11	dissolution	dissolution	NOUN
admet-2861	454	12	methodologies	methodology	NOUN
admet-2861	454	13	and	and	CCONJ
admet-2861	454	14	their	their	PRON
admet-2861	454	15	correlation	correlation	NOUN
admet-2861	454	16	with	with	ADP
admet-2861	454	17	the	the	DET
admet-2861	454	18	biopharmaceutical	biopharmaceutical	ADJ
admet-2861	454	19	aspects	aspect	NOUN
admet-2861	454	20	of	of	ADP
admet-2861	454	21	the	the	DET
admet-2861	454	22	drug	drug	NOUN
admet-2861	454	23	products	product	NOUN
admet-2861	454	24	.	.	PUNCT
admet-2861	455	1	european	european	ADJ
admet-2861	455	2	journal	journal	PROPN
admet-2861	455	3	of	of	ADP
admet-2861	455	4	pharmaceutical	pharmaceutical	PROPN
admet-2861	455	5	sciences	science	NOUN
admet-2861	455	6	113	113	NUM
admet-2861	455	7	(	(	PUNCT
admet-2861	455	8	2018	2018	NUM
admet-2861	455	9	)	)	PUNCT
admet-2861	455	10	18	18	NUM
admet-2861	455	11	-	-	SYM
admet-2861	455	12	28	28	NUM
admet-2861	455	13	.	.	PUNCT
admet-2861	456	1	https://doi.org/10.1016/j.ejps.2017.09.002	https://doi.org/10.1016/j.ejps.2017.09.002	PROPN
admet-2861	456	2	.	.	PUNCT
admet-2861	457	1	[	[	X
admet-2861	457	2	25	25	NUM
admet-2861	457	3	]	]	PUNCT
admet-2861	457	4	b.	b.	PROPN
admet-2861	457	5	falade	falade	PROPN
admet-2861	457	6	,	,	PUNCT
admet-2861	457	7	c.	c.	PROPN
admet-2861	457	8	ehrhardt	ehrhardt	PROPN
admet-2861	457	9	.	.	PUNCT
admet-2861	458	1	in	in	ADP
admet-2861	458	2	vitro	vitro	X
admet-2861	458	3	dissolution	dissolution	NOUN
admet-2861	458	4	testing	testing	NOUN
admet-2861	458	5	methods	method	NOUN
admet-2861	458	6	for	for	ADP
admet-2861	458	7	inhaled	inhaled	ADJ
admet-2861	458	8	drugs	drug	NOUN
admet-2861	458	9	.	.	PUNCT
admet-2861	459	1	istanbul	istanbul	PROPN
admet-2861	459	2	journal	journal	PROPN
admet-2861	459	3	of	of	ADP
admet-2861	459	4	pharmacy	pharmacy	NOUN
admet-2861	459	5	53	53	NUM
admet-2861	459	6	(	(	PUNCT
admet-2861	459	7	2023	2023	NUM
admet-2861	459	8	)	)	PUNCT
admet-2861	459	9	239	239	NUM
admet-2861	459	10	-	-	SYM
admet-2861	459	11	250	250	NUM
admet-2861	459	12	.	.	PUNCT
admet-2861	460	1	https://doi.org/10.26650/istanbuljpharm.2023.1005069	https://doi.org/10.26650/istanbuljpharm.2023.1005069	PROPN
admet-2861	460	2	[	[	X
admet-2861	460	3	26	26	NUM
admet-2861	460	4	]	]	PUNCT
admet-2861	460	5	s.	s.	PROPN
admet-2861	460	6	radivojev	radivojev	PROPN
admet-2861	460	7	,	,	PUNCT
admet-2861	460	8	s.	s.	PROPN
admet-2861	460	9	zellnitz	zellnitz	PROPN
admet-2861	460	10	,	,	PUNCT
admet-2861	460	11	a.	a.	NOUN
admet-2861	460	12	paudel	paudel	PROPN
admet-2861	460	13	,	,	PUNCT
admet-2861	460	14	e.	e.	PROPN
admet-2861	460	15	fröhlich	fröhlich	PROPN
admet-2861	460	16	.	.	PUNCT
admet-2861	461	1	searching	search	VERB
admet-2861	461	2	for	for	ADP
admet-2861	461	3	physiologically	physiologically	ADV
admet-2861	461	4	relevant	relevant	ADJ
admet-2861	461	5	in	in	ADP
admet-2861	461	6	vitro	vitro	X
admet-2861	461	7	dissolution	dissolution	NOUN
admet-2861	461	8	techniques	technique	NOUN
admet-2861	461	9	for	for	ADP
admet-2861	461	10	orally	orally	ADV
admet-2861	461	11	inhaled	inhale	VERB
admet-2861	461	12	drugs	drug	NOUN
admet-2861	461	13	.	.	PUNCT
admet-2861	462	1	international	international	ADJ
admet-2861	462	2	journal	journal	PROPN
admet-2861	462	3	of	of	ADP
admet-2861	462	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	462	5	556	556	NUM
admet-2861	462	6	(	(	PUNCT
admet-2861	462	7	2019	2019	NUM
admet-2861	462	8	)	)	PUNCT
admet-2861	462	9	4556	4556	NUM
admet-2861	462	10	.	.	PUNCT
admet-2861	463	1	https://doi.org/10.1016/j.ijpharm.2018.11.072	https://doi.org/10.1016/j.ijpharm.2018.11.072	NOUN
admet-2861	463	2	.	.	PUNCT
admet-2861	464	1	[	[	X
admet-2861	464	2	27	27	NUM
admet-2861	464	3	]	]	SYM
admet-2861	464	4	elezović	elezović	ADJ
admet-2861	464	5	,	,	PUNCT
admet-2861	464	6	s.	s.	PROPN
admet-2861	464	7	cvijić	cvijić	PROPN
admet-2861	464	8	,	,	PUNCT
admet-2861	464	9	a.	a.	NOUN
admet-2861	464	10	elezović	elezović	PROPN
admet-2861	464	11	,	,	PUNCT
admet-2861	464	12	s.	s.	PROPN
admet-2861	464	13	pilipović	pilipović	PROPN
admet-2861	464	14	,	,	PUNCT
admet-2861	464	15	a.	a.	NOUN
admet-2861	464	16	uzunović	uzunović	PROPN
admet-2861	464	17	,	,	PUNCT
admet-2861	464	18	j.	j.	PROPN
admet-2861	464	19	parojčić	parojčić	PROPN
admet-2861	464	20	.	.	PUNCT
admet-2861	465	1	contribution	contribution	NOUN
admet-2861	465	2	to	to	ADP
admet-2861	465	3	development	development	NOUN
admet-2861	465	4	of	of	ADP
admet-2861	465	5	discriminative	discriminative	NOUN
admet-2861	465	6	dissolution	dissolution	NOUN
admet-2861	465	7	method	method	NOUN
admet-2861	465	8	for	for	ADP
admet-2861	465	9	inhalation	inhalation	NOUN
admet-2861	465	10	preparations	preparation	NOUN
admet-2861	465	11	.	.	PUNCT
admet-2861	466	1	in	in	ADP
admet-2861	466	2	:	:	PUNCT
admet-2861	466	3	b.	b.	PROPN
admet-2861	466	4	noszal	noszal	PROPN
admet-2861	466	5	(	(	PUNCT
admet-2861	466	6	ed	ed	NOUN
admet-2861	466	7	.	.	PUNCT
admet-2861	466	8	)	)	PUNCT
admet-2861	467	1	xii	xii	NOUN
admet-2861	467	2	central	central	ADJ
admet-2861	467	3	european	european	ADJ
admet-2861	467	4	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	468	1	https://doi.org/10.3390/pharmaceutics13101541	https://doi.org/10.3390/pharmaceutics13101541	PRON
admet-2861	468	2	https://www.mdpi.com/1999-4923/16/8/989	https://www.mdpi.com/1999-4923/16/8/989	PUNCT
admet-2861	469	1	https://doi.org/10.1021/acs.molpharmaceut.5b00221	https://doi.org/10.1021/acs.molpharmaceut.5b00221	VERB
admet-2861	469	2	https://doi.org/10.1007/s11095-010-0070-5	https://doi.org/10.1007/s11095-010-0070-5	PROPN
admet-2861	469	3	https://doi.org/10.1021/acs.molpharmaceut.8b00796	https://doi.org/10.1021/acs.molpharmaceut.8b00796	AUX
admet-2861	469	4	https://doi.org/10.1016/s0378-5173(03)00091-7	https://doi.org/10.1016/s0378-5173(03)00091-7	PROPN
admet-2861	469	5	https://doi.org/10.1016/s0378-5173(03)00091-7	https://doi.org/10.1016/s0378-5173(03)00091-7	PROPN
admet-2861	469	6	https://doi.org/10.1081/ddc-100100991	https://doi.org/10.1081/ddc-100100991	PROPN
admet-2861	469	7	https://doi.org/10.1016/j.ijpharm.2009.07.034	https://doi.org/10.1016/j.ijpharm.2009.07.034	NOUN
admet-2861	469	8	https://doi.org/10.1007/s11095-012-0744-2	https://doi.org/10.1007/s11095-012-0744-2	NUM
admet-2861	470	1	https://doi.org/10.1089/adt.2017.779	https://doi.org/10.1089/adt.2017.779	PROPN
admet-2861	470	2	https://www.inhalation.se/inhalation-research-services/dissolvit-in-vitro-dissolution/	https://www.inhalation.se/inhalation-research-services/dissolvit-in-vitro-dissolution/	PROPN
admet-2861	470	3	https://www.inhalation.se/inhalation-research-services/dissolvit-in-vitro-dissolution/	https://www.inhalation.se/inhalation-research-services/dissolvit-in-vitro-dissolution/	PROPN
admet-2861	471	1	https://doi.org/10.1016/j.jaerosci.2020.105698	https://doi.org/10.1016/j.jaerosci.2020.105698	PROPN
admet-2861	471	2	https://doi.org/10.1016/j.ejps.2017.09.002	https://doi.org/10.1016/j.ejps.2017.09.002	PROPN
admet-2861	471	3	http://dx.doi.org/10.26650/istanbuljpharm.2023.1005069	http://dx.doi.org/10.26650/istanbuljpharm.2023.1005069	NOUN
admet-2861	471	4	https://doi.org/10.1016/j.ijpharm.2018.11.072	https://doi.org/10.1016/j.ijpharm.2018.11.072	NOUN
admet-2861	471	5	a.	a.	NOUN
admet-2861	471	6	elezović	elezović	NOUN
admet-2861	471	7	et	et	PROPN
admet-2861	471	8	al	al	PROPN
admet-2861	471	9	.	.	PROPN
admet-2861	471	10	admet	admet	PROPN
admet-2861	471	11	&	&	CCONJ
admet-2861	471	12	dmpk	dmpk	PROPN
admet-2861	471	13	13(5	13(5	NUM
admet-2861	471	14	)	)	PUNCT
admet-2861	471	15	(	(	PUNCT
admet-2861	471	16	2025	2025	NUM
admet-2861	471	17	)	)	PUNCT
admet-2861	471	18	2861	2861	NUM
admet-2861	471	19	22	22	NUM
admet-2861	471	20	symposium	symposium	NOUN
admet-2861	471	21	on	on	ADP
admet-2861	471	22	pharmaceutical	pharmaceutical	ADJ
admet-2861	471	23	technology	technology	NOUN
admet-2861	471	24	and	and	CCONJ
admet-2861	471	25	regulatory	regulatory	ADJ
admet-2861	471	26	affairs	affairs	PROPN
admet-2861	471	27	szeged	szeged	PROPN
admet-2861	471	28	,	,	PUNCT
admet-2861	471	29	hungary	hungary	PROPN
admet-2861	471	30	,	,	PUNCT
admet-2861	471	31	2018	2018	NUM
admet-2861	471	32	,	,	PUNCT
admet-2861	471	33	pp	pp	ADJ
admet-2861	471	34	.	.	PUNCT
admet-2861	472	1	134	134	NUM
admet-2861	472	2	-	-	SYM
admet-2861	472	3	135	135	NUM
admet-2861	472	4	.	.	PUNCT
admet-2861	473	1	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discrimin	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discrimin	PROPN
admet-2861	473	2	ative_dissolution_method_for_inhalation_preparations	ative_dissolution_method_for_inhalation_preparation	NOUN
admet-2861	473	3	[	[	X
admet-2861	473	4	28	28	NUM
admet-2861	473	5	]	]	X
admet-2861	473	6	m.n	m.n	PROPN
admet-2861	473	7	.	.	PROPN
admet-2861	473	8	sahib	sahib	NOUN
admet-2861	473	9	,	,	PUNCT
admet-2861	473	10	y.	y.	PROPN
admet-2861	473	11	darwis	darwis	PROPN
admet-2861	473	12	,	,	PUNCT
admet-2861	473	13	p.k	p.k	PROPN
admet-2861	473	14	.	.	PROPN
admet-2861	473	15	khiang	khiang	PROPN
admet-2861	473	16	,	,	PUNCT
admet-2861	473	17	y.t	y.t	PROPN
admet-2861	473	18	.	.	PROPN
admet-2861	473	19	fung	fung	PROPN
admet-2861	473	20	tan	tan	PROPN
admet-2861	473	21	.	.	PUNCT
admet-2861	474	1	aerodynamic	aerodynamic	ADJ
admet-2861	474	2	characterization	characterization	NOUN
admet-2861	474	3	of	of	ADP
admet-2861	474	4	beclomethasone	beclomethasone	ADJ
admet-2861	474	5	dipropionate	dipropionate	NOUN
admet-2861	474	6	from	from	ADP
admet-2861	474	7	beclate-50	beclate-50	ADJ
admet-2861	474	8	inhaler	inhaler	NOUN
admet-2861	474	9	®	®	NOUN
admet-2861	474	10	by	by	ADP
admet-2861	474	11	hplc	hplc	NOUN
admet-2861	474	12	-	-	PUNCT
admet-2861	474	13	uv	uv	NOUN
admet-2861	474	14	.	.	PROPN
admet-2861	474	15	journal	journal	NOUN
admet-2861	474	16	of	of	ADP
admet-2861	474	17	liquid	liquid	ADJ
admet-2861	474	18	chromatography	chromatography	NOUN
admet-2861	474	19	&	&	CCONJ
admet-2861	474	20	related	related	ADJ
admet-2861	474	21	technologies	technology	NOUN
admet-2861	474	22	34	34	NUM
admet-2861	474	23	(	(	PUNCT
admet-2861	474	24	2011	2011	NUM
admet-2861	474	25	)	)	PUNCT
admet-2861	474	26	613	613	NUM
admet-2861	474	27	-	-	SYM
admet-2861	474	28	621	621	NUM
admet-2861	474	29	.	.	PUNCT
admet-2861	475	1	https://doi.org/10.1080/10826076.2011.557464	https://doi.org/10.1080/10826076.2011.557464	NOUN
admet-2861	475	2	.	.	PUNCT
admet-2861	476	1	[	[	X
admet-2861	476	2	29	29	NUM
admet-2861	476	3	]	]	X
admet-2861	476	4	e.	e.	PROPN
admet-2861	476	5	paczkowska	paczkowska	PROPN
admet-2861	476	6	,	,	PUNCT
admet-2861	476	7	d.	d.	PROPN
admet-2861	476	8	smukowska	smukowska	PROPN
admet-2861	476	9	,	,	PUNCT
admet-2861	476	10	e.	e.	PROPN
admet-2861	476	11	tratkiewicz	tratkiewicz	PROPN
admet-2861	476	12	,	,	PUNCT
admet-2861	476	13	p.	p.	PROPN
admet-2861	476	14	bialasiewicz	bialasiewicz	NOUN
admet-2861	476	15	.	.	PUNCT
admet-2861	477	1	hplc	hplc	NOUN
admet-2861	477	2	method	method	NOUN
admet-2861	477	3	for	for	ADP
admet-2861	477	4	simultaneous	simultaneous	ADJ
admet-2861	477	5	determination	determination	NOUN
admet-2861	477	6	of	of	ADP
admet-2861	477	7	salmeterol	salmeterol	NOUN
admet-2861	477	8	xinafoate	xinafoate	ADJ
admet-2861	477	9	and	and	CCONJ
admet-2861	477	10	fluticasone	fluticasone	NOUN
admet-2861	477	11	propionate	propionate	NOUN
admet-2861	477	12	for	for	ADP
admet-2861	477	13	the	the	DET
admet-2861	477	14	quality	quality	NOUN
admet-2861	477	15	control	control	NOUN
admet-2861	477	16	of	of	ADP
admet-2861	477	17	dry	dry	ADJ
admet-2861	477	18	powder	powder	NOUN
admet-2861	477	19	inhalation	inhalation	NOUN
admet-2861	477	20	products	product	NOUN
admet-2861	477	21	.	.	PUNCT
admet-2861	478	1	acta	acta	PROPN
admet-2861	478	2	chromatographica	chromatographica	PROPN
admet-2861	478	3	27	27	NUM
admet-2861	478	4	(	(	PUNCT
admet-2861	478	5	2015	2015	NUM
admet-2861	478	6	.	.	PUNCT
admet-2861	478	7	)	)	PUNCT
admet-2861	479	1	309	309	NUM
admet-2861	479	2	-	-	SYM
admet-2861	479	3	320	320	NUM
admet-2861	479	4	.	.	PUNCT
admet-2861	480	1	https://doi.org/10.1556/achrom.27.2015.2.8	https://doi.org/10.1556/achrom.27.2015.2.8	NOUN
admet-2861	480	2	.	.	PUNCT
admet-2861	481	1	[	[	X
admet-2861	481	2	30	30	NUM
admet-2861	481	3	]	]	X
admet-2861	481	4	p.t	p.t	PROPN
admet-2861	481	5	.	.	PUNCT
admet-2861	481	6	daley	daley	PROPN
admet-2861	481	7	-	-	PUNCT
admet-2861	481	8	yates	yates	PROPN
admet-2861	481	9	,	,	PUNCT
admet-2861	481	10	a.c	a.c	PROPN
admet-2861	481	11	.	.	PROPN
admet-2861	481	12	price	price	NOUN
admet-2861	481	13	,	,	PUNCT
admet-2861	481	14	j.r	j.r	PROPN
admet-2861	481	15	.	.	PROPN
admet-2861	481	16	sisson	sisson	PROPN
admet-2861	481	17	,	,	PUNCT
admet-2861	481	18	a.	a.	PROPN
admet-2861	481	19	pereira	pereira	PROPN
admet-2861	481	20	,	,	PUNCT
admet-2861	481	21	n.	n.	PROPN
admet-2861	481	22	dallow	dallow	NOUN
admet-2861	481	23	.	.	PUNCT
admet-2861	482	1	beclomethasone	beclomethasone	ADJ
admet-2861	482	2	dipropionate	dipropionate	NOUN
admet-2861	482	3	:	:	PUNCT
admet-2861	482	4	absolute	absolute	ADJ
admet-2861	482	5	bioavailability	bioavailability	NOUN
admet-2861	482	6	,	,	PUNCT
admet-2861	482	7	pharmacokinetics	pharmacokinetic	NOUN
admet-2861	482	8	and	and	CCONJ
admet-2861	482	9	metabolism	metabolism	NOUN
admet-2861	482	10	following	follow	VERB
admet-2861	482	11	intravenous	intravenous	ADJ
admet-2861	482	12	,	,	PUNCT
admet-2861	482	13	oral	oral	ADJ
admet-2861	482	14	,	,	PUNCT
admet-2861	482	15	intranasal	intranasal	ADJ
admet-2861	482	16	and	and	CCONJ
admet-2861	482	17	inhaled	inhaled	ADJ
admet-2861	482	18	administration	administration	NOUN
admet-2861	482	19	in	in	ADP
admet-2861	482	20	man	man	NOUN
admet-2861	482	21	.	.	PUNCT
admet-2861	483	1	british	british	ADJ
admet-2861	483	2	journal	journal	PROPN
admet-2861	483	3	of	of	ADP
admet-2861	483	4	clinical	clinical	ADJ
admet-2861	483	5	pharmacology	pharmacology	NOUN
admet-2861	483	6	51	51	NUM
admet-2861	483	7	(	(	PUNCT
admet-2861	483	8	2001	2001	NUM
admet-2861	483	9	)	)	PUNCT
admet-2861	483	10	400	400	NUM
admet-2861	483	11	-	-	SYM
admet-2861	483	12	409	409	NUM
admet-2861	483	13	.	.	PUNCT
admet-2861	484	1	https://doi.org/10.1046/j.0306-5251.2001.01374.x	https://doi.org/10.1046/j.0306-5251.2001.01374.x	PROPN
admet-2861	484	2	.	.	PUNCT
admet-2861	485	1	[	[	X
admet-2861	485	2	31	31	NUM
admet-2861	485	3	]	]	PUNCT
admet-2861	485	4	a.	a.	NOUN
admet-2861	485	5	elezović	elezović	PROPN
admet-2861	485	6	,	,	PUNCT
admet-2861	485	7	s.	s.	PROPN
admet-2861	485	8	cvijić	cvijić	PROPN
admet-2861	485	9	,	,	PUNCT
admet-2861	485	10	a.	a.	NOUN
admet-2861	485	11	elezović	elezović	PROPN
admet-2861	485	12	,	,	PUNCT
admet-2861	485	13	s.	s.	PROPN
admet-2861	485	14	pilipović	pilipović	PROPN
admet-2861	485	15	,	,	PUNCT
admet-2861	485	16	j.	j.	PROPN
admet-2861	485	17	parojčić	parojčić	PROPN
admet-2861	485	18	,	,	PUNCT
admet-2861	485	19	particle	particle	NOUN
admet-2861	485	20	deposition	deposition	NOUN
admet-2861	485	21	in	in	ADP
admet-2861	485	22	respiratory	respiratory	ADJ
admet-2861	485	23	tract	tract	NOUN
admet-2861	485	24	:	:	PUNCT
admet-2861	485	25	where	where	SCONJ
admet-2861	485	26	are	be	AUX
admet-2861	485	27	the	the	DET
admet-2861	485	28	limits	limit	NOUN
admet-2861	485	29	?	?	PUNCT
admet-2861	485	30	.	.	PUNCT
admet-2861	486	1	in	in	ADP
admet-2861	486	2	:	:	PUNCT
admet-2861	486	3	a.	a.	NOUN
admet-2861	486	4	badnjevic	badnjevic	PROPN
admet-2861	486	5	,	,	PUNCT
admet-2861	486	6	l.	l.	PROPN
admet-2861	486	7	gurbeta	gurbeta	PROPN
admet-2861	486	8	pokvić	pokvić	PROPN
admet-2861	486	9	,	,	PUNCT
admet-2861	486	10	(	(	PUNCT
admet-2861	486	11	eds	ed	NOUN
admet-2861	486	12	.	.	PUNCT
admet-2861	486	13	)	)	PUNCT
admet-2861	486	14	cmbebih	cmbebih	PROPN
admet-2861	486	15	2021	2021	NUM
admet-2861	486	16	.	.	PUNCT
admet-2861	487	1	cmbebih	cmbebih	PROPN
admet-2861	487	2	2021	2021	NUM
admet-2861	487	3	.	.	PUNCT
admet-2861	488	1	ifmbe	ifmbe	ADJ
admet-2861	488	2	proceedings	proceeding	NOUN
admet-2861	488	3	,	,	PUNCT
admet-2861	488	4	vol	vol	NOUN
admet-2861	488	5	84	84	NUM
admet-2861	488	6	.	.	PUNCT
admet-2861	489	1	springer	springer	NOUN
admet-2861	489	2	,	,	PUNCT
admet-2861	489	3	cham	cham	PROPN
admet-2861	489	4	.	.	PUNCT
admet-2861	489	5	,	,	PUNCT
admet-2861	490	1	pp	pp	PROPN
admet-2861	490	2	.	.	PUNCT
admet-2861	491	1	638	638	NUM
admet-2861	491	2	-	-	SYM
admet-2861	491	3	644	644	NUM
admet-2861	491	4	.	.	PUNCT
admet-2861	492	1	https://doi.org/10.1007/978-3-030-73909-6_74	https://doi.org/10.1007/978-3-030-73909-6_74	PUNCT
admet-2861	492	2	[	[	X
admet-2861	492	3	32	32	NUM
admet-2861	492	4	]	]	X
admet-2861	492	5	l.i	l.i	PROPN
admet-2861	492	6	.	.	PROPN
admet-2861	492	7	harrison	harrison	PROPN
admet-2861	492	8	,	,	PUNCT
admet-2861	492	9	s.	s.	PROPN
admet-2861	492	10	kurup	kurup	PROPN
admet-2861	492	11	,	,	PUNCT
admet-2861	492	12	c.	c.	PROPN
admet-2861	492	13	wagner	wagner	PROPN
admet-2861	492	14	,	,	PUNCT
admet-2861	492	15	b.p	b.p	PROPN
admet-2861	492	16	.	.	PROPN
admet-2861	492	17	ekholm	ekholm	PROPN
admet-2861	492	18	,	,	PUNCT
admet-2861	492	19	j.s	j.s	PROPN
admet-2861	492	20	.	.	PROPN
admet-2861	492	21	larson	larson	PROPN
admet-2861	492	22	,	,	PUNCT
admet-2861	492	23	h.b	h.b	PROPN
admet-2861	492	24	.	.	PROPN
admet-2861	492	25	kaiser	kaiser	PROPN
admet-2861	492	26	.	.	PUNCT
admet-2861	493	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2861	493	2	of	of	ADP
admet-2861	493	3	beclomethasone	beclomethasone	ADJ
admet-2861	493	4	17	17	NUM
admet-2861	493	5	-	-	PUNCT
admet-2861	493	6	monopropionate	monopropionate	NOUN
admet-2861	493	7	from	from	ADP
admet-2861	493	8	a	a	DET
admet-2861	493	9	beclomethasone	beclomethasone	ADJ
admet-2861	493	10	dipropionate	dipropionate	NOUN
admet-2861	493	11	extrafine	extrafine	NOUN
admet-2861	493	12	aerosol	aerosol	NOUN
admet-2861	493	13	in	in	ADP
admet-2861	493	14	adults	adult	NOUN
admet-2861	493	15	with	with	ADP
admet-2861	493	16	asthma	asthma	NOUN
admet-2861	493	17	.	.	PUNCT
admet-2861	494	1	european	european	ADJ
admet-2861	494	2	journal	journal	PROPN
admet-2861	494	3	of	of	ADP
admet-2861	494	4	clinical	clinical	ADJ
admet-2861	494	5	pharmacology	pharmacology	NOUN
admet-2861	494	6	58	58	NUM
admet-2861	494	7	(	(	PUNCT
admet-2861	494	8	2002	2002	NUM
admet-2861	494	9	)	)	PUNCT
admet-2861	494	10	197	197	NUM
admet-2861	494	11	-	-	SYM
admet-2861	494	12	201	201	NUM
admet-2861	494	13	.	.	PUNCT
admet-2861	494	14	https://doi.org/10.1007/s00228-002-0466-1	https://doi.org/10.1007/s00228-002-0466-1	NOUN
admet-2861	494	15	.	.	PUNCT
admet-2861	495	1	[	[	X
admet-2861	495	2	33	33	NUM
admet-2861	495	3	]	]	X
admet-2861	495	4	d.	d.	PROPN
admet-2861	495	5	singh	singh	PROPN
admet-2861	495	6	,	,	PUNCT
admet-2861	495	7	a.	a.	NOUN
admet-2861	495	8	piccinno	piccinno	PROPN
admet-2861	495	9	,	,	PUNCT
admet-2861	495	10	z.	z.	PROPN
admet-2861	495	11	borrill	borrill	PROPN
admet-2861	495	12	,	,	PUNCT
admet-2861	495	13	g.	g.	PROPN
admet-2861	495	14	poli	poli	PROPN
admet-2861	495	15	,	,	PUNCT
admet-2861	495	16	d.	d.	PROPN
admet-2861	495	17	acerbi	acerbi	PROPN
admet-2861	495	18	,	,	PUNCT
admet-2861	495	19	l.	l.	PROPN
admet-2861	495	20	meuleners	meuleners	PROPN
admet-2861	495	21	,	,	PUNCT
admet-2861	495	22	a.	a.	NOUN
admet-2861	495	23	woodcock	woodcock	NOUN
admet-2861	495	24	.	.	PUNCT
admet-2861	496	1	tolerability	tolerability	NOUN
admet-2861	496	2	of	of	ADP
admet-2861	496	3	high	high	ADJ
admet-2861	496	4	cumulative	cumulative	ADJ
admet-2861	496	5	doses	dose	NOUN
admet-2861	496	6	of	of	ADP
admet-2861	496	7	the	the	DET
admet-2861	496	8	hfa	hfa	PROPN
admet-2861	496	9	modulite	modulite	NOUN
admet-2861	496	10	beclomethasone	beclomethasone	NOUN
admet-2861	496	11	dipropionate	dipropionate	NOUN
admet-2861	496	12	/	/	SYM
admet-2861	496	13	formoterol	formoterol	NOUN
admet-2861	496	14	combination	combination	NOUN
admet-2861	496	15	inhaler	inhaler	NOUN
admet-2861	496	16	in	in	ADP
admet-2861	496	17	asthmatic	asthmatic	ADJ
admet-2861	496	18	patients	patient	NOUN
admet-2861	496	19	.	.	PUNCT
admet-2861	497	1	pulmonary	pulmonary	ADJ
admet-2861	497	2	pharmacology	pharmacology	NOUN
admet-2861	497	3	&	&	CCONJ
admet-2861	497	4	therapeutics	therapeutic	NOUN
admet-2861	497	5	21	21	NUM
admet-2861	497	6	(	(	PUNCT
admet-2861	497	7	2008	2008	NUM
admet-2861	497	8	)	)	PUNCT
admet-2861	497	9	551	551	NUM
admet-2861	497	10	-	-	SYM
admet-2861	497	11	557	557	NUM
admet-2861	497	12	.	.	PUNCT
admet-2861	498	1	https://doi.org/10.1016/j.pupt.2008.01.001	https://doi.org/10.1016/j.pupt.2008.01.001	VERB
admet-2861	498	2	.	.	PUNCT
admet-2861	499	1	[	[	X
admet-2861	499	2	34	34	NUM
admet-2861	499	3	]	]	X
admet-2861	499	4	european	european	PROPN
admet-2861	499	5	medicines	medicine	NOUN
admet-2861	499	6	agency	agency	NOUN
admet-2861	499	7	.	.	PUNCT
admet-2861	500	1	guideline	guideline	NOUN
admet-2861	500	2	on	on	ADP
admet-2861	500	3	the	the	DET
admet-2861	500	4	requirements	requirement	NOUN
admet-2861	500	5	for	for	ADP
admet-2861	500	6	clinical	clinical	ADJ
admet-2861	500	7	documentation	documentation	NOUN
admet-2861	500	8	for	for	ADP
admet-2861	500	9	orally	orally	ADV
admet-2861	500	10	inhaled	inhaled	ADJ
admet-2861	500	11	products	product	NOUN
admet-2861	500	12	(	(	PUNCT
admet-2861	500	13	oio	oio	X
admet-2861	500	14	)	)	PUNCT
admet-2861	500	15	including	include	VERB
admet-2861	500	16	the	the	DET
admet-2861	500	17	requirements	requirement	NOUN
admet-2861	500	18	for	for	ADP
admet-2861	500	19	demonstration	demonstration	NOUN
admet-2861	500	20	of	of	ADP
admet-2861	500	21	therapeutic	therapeutic	ADJ
admet-2861	500	22	equivalence	equivalence	NOUN
admet-2861	500	23	between	between	ADP
admet-2861	500	24	two	two	NUM
admet-2861	500	25	inhaled	inhaled	ADJ
admet-2861	500	26	products	product	NOUN
admet-2861	500	27	for	for	ADP
admet-2861	500	28	use	use	NOUN
admet-2861	500	29	in	in	ADP
admet-2861	500	30	the	the	DET
admet-2861	500	31	treatment	treatment	NOUN
admet-2861	500	32	of	of	ADP
admet-2861	500	33	asthma	asthma	NOUN
admet-2861	500	34	and	and	CCONJ
admet-2861	500	35	chronic	chronic	ADJ
admet-2861	500	36	obstructive	obstructive	ADJ
admet-2861	500	37	pulmonary	pulmonary	ADJ
admet-2861	500	38	disease	disease	NOUN
admet-2861	500	39	(	(	PUNCT
admet-2861	500	40	copd	copd	NOUN
admet-2861	500	41	)	)	PUNCT
admet-2861	500	42	in	in	ADP
admet-2861	500	43	adults	adult	NOUN
admet-2861	500	44	and	and	CCONJ
admet-2861	500	45	for	for	ADP
admet-2861	500	46	use	use	NOUN
admet-2861	500	47	in	in	ADP
admet-2861	500	48	the	the	DET
admet-2861	500	49	treatment	treatment	NOUN
admet-2861	500	50	of	of	ADP
admet-2861	500	51	asthma	asthma	NOUN
admet-2861	500	52	in	in	ADP
admet-2861	500	53	children	child	NOUN
admet-2861	500	54	and	and	CCONJ
admet-2861	500	55	adolescents	adolescent	NOUN
admet-2861	500	56	.	.	PUNCT
admet-2861	501	1	in	in	ADP
admet-2861	501	2	:	:	PUNCT
admet-2861	501	3	european	european	ADJ
admet-2861	501	4	medicines	medicine	NOUN
admet-2861	501	5	agency	agency	NOUN
admet-2861	501	6	(	(	PUNCT
admet-2861	501	7	ed	ed	NOUN
admet-2861	501	8	.	.	PUNCT
admet-2861	501	9	)	)	PUNCT
admet-2861	502	1	london	london	PROPN
admet-2861	502	2	,	,	PUNCT
admet-2861	502	3	uk	uk	PROPN
admet-2861	502	4	,	,	PUNCT
admet-2861	502	5	2009	2009	NUM
admet-2861	502	6	.	.	PUNCT
admet-2861	503	1	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinicaldocumentation-orally-inhaled-products-including-requirements-demonstration-therapeuticequivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinicaldocumentation-orally-inhaled-products-including-requirements-demonstration-therapeuticequivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	NOUN
admet-2861	503	2	(	(	PUNCT
admet-2861	503	3	accessed	access	VERB
admet-2861	503	4	:	:	PUNCT
admet-2861	503	5	28.04.2025	28.04.2025	NUM
admet-2861	503	6	.	.	PUNCT
admet-2861	503	7	)	)	PUNCT
admet-2861	504	1	[	[	X
admet-2861	504	2	35	35	NUM
admet-2861	504	3	]	]	X
admet-2861	504	4	b.	b.	NOUN
admet-2861	504	5	bake	bake	PROPN
admet-2861	504	6	,	,	PUNCT
admet-2861	504	7	p.	p.	NOUN
admet-2861	504	8	larsson	larsson	PROPN
admet-2861	504	9	,	,	PUNCT
admet-2861	504	10	g.	g.	PROPN
admet-2861	504	11	ljungkvist	ljungkvist	PROPN
admet-2861	504	12	,	,	PUNCT
admet-2861	504	13	e.	e.	PROPN
admet-2861	504	14	ljungström	ljungström	PROPN
admet-2861	504	15	,	,	PUNCT
admet-2861	504	16	a.c	a.c	PROPN
admet-2861	504	17	.	.	PROPN
admet-2861	504	18	olin	olin	PROPN
admet-2861	504	19	.	.	PROPN
admet-2861	504	20	exhaled	exhale	VERB
admet-2861	504	21	particles	particle	NOUN
admet-2861	504	22	and	and	CCONJ
admet-2861	504	23	small	small	ADJ
admet-2861	504	24	airways	airway	NOUN
admet-2861	504	25	.	.	PUNCT
admet-2861	505	1	respiratory	respiratory	ADJ
admet-2861	505	2	research	research	NOUN
admet-2861	505	3	20	20	NUM
admet-2861	505	4	(	(	PUNCT
admet-2861	505	5	2019	2019	NUM
admet-2861	505	6	)	)	PUNCT
admet-2861	505	7	8	8	NUM
admet-2861	505	8	.	.	PUNCT
admet-2861	505	9	https://doi.org/10.1186/s12931-019-0970-9	https://doi.org/10.1186/s12931-019-0970-9	NUM
admet-2861	505	10	.	.	PUNCT
admet-2861	506	1	[	[	X
admet-2861	506	2	36	36	NUM
admet-2861	506	3	]	]	X
admet-2861	506	4	h.	h.	PROPN
admet-2861	506	5	bachofen	bachofen	PROPN
admet-2861	506	6	,	,	PUNCT
admet-2861	506	7	s.	s.	PROPN
admet-2861	506	8	schürch	schürch	PROPN
admet-2861	506	9	.	.	PUNCT
admet-2861	507	1	alveolar	alveolar	ADJ
admet-2861	507	2	surface	surface	NOUN
admet-2861	507	3	forces	force	NOUN
admet-2861	507	4	and	and	CCONJ
admet-2861	507	5	lung	lung	NOUN
admet-2861	507	6	architecture	architecture	NOUN
admet-2861	507	7	.	.	PUNCT
admet-2861	508	1	comparative	comparative	ADJ
admet-2861	508	2	biochemistry	biochemistry	NOUN
admet-2861	508	3	and	and	CCONJ
admet-2861	508	4	physiology	physiology	NOUN
admet-2861	508	5	part	part	NOUN
admet-2861	508	6	a	a	DET
admet-2861	508	7	:	:	PUNCT
admet-2861	508	8	molecular	molecular	ADJ
admet-2861	508	9	&	&	CCONJ
admet-2861	508	10	integrative	integrative	ADJ
admet-2861	508	11	physiology	physiology	NOUN
admet-2861	508	12	129(1	129(1	NUM
admet-2861	508	13	)	)	PUNCT
admet-2861	508	14	(	(	PUNCT
admet-2861	508	15	2001	2001	NUM
admet-2861	508	16	)	)	PUNCT
admet-2861	508	17	183	183	NUM
admet-2861	508	18	-	-	SYM
admet-2861	508	19	193	193	NUM
admet-2861	508	20	.	.	PUNCT
admet-2861	509	1	https://doi.org/10.1016/s1095-6433(01)00315-4	https://doi.org/10.1016/s1095-6433(01)00315-4	PROPN
admet-2861	509	2	.	.	PUNCT
admet-2861	510	1	[	[	X
admet-2861	510	2	37	37	NUM
admet-2861	510	3	]	]	X
admet-2861	510	4	a.w	a.w	PROPN
admet-2861	510	5	.	.	PROPN
admet-2861	510	6	ng	ng	PROPN
admet-2861	510	7	,	,	PUNCT
admet-2861	510	8	a.	a.	PROPN
admet-2861	510	9	bidani	bidani	PROPN
admet-2861	510	10	,	,	PUNCT
admet-2861	510	11	t.a	t.a	PROPN
admet-2861	510	12	.	.	PROPN
admet-2861	510	13	heming	heming	PROPN
admet-2861	510	14	.	.	PUNCT
admet-2861	510	15	innate	innate	ADJ
admet-2861	510	16	host	host	NOUN
admet-2861	510	17	defense	defense	NOUN
admet-2861	510	18	of	of	ADP
admet-2861	510	19	the	the	DET
admet-2861	510	20	lung	lung	NOUN
admet-2861	510	21	:	:	PUNCT
admet-2861	510	22	effects	effect	NOUN
admet-2861	510	23	of	of	ADP
admet-2861	510	24	lung	lung	NOUN
admet-2861	510	25	-	-	PUNCT
admet-2861	510	26	lining	line	VERB
admet-2861	510	27	fluid	fluid	NOUN
admet-2861	510	28	ph	ph	NOUN
admet-2861	510	29	.	.	PUNCT
admet-2861	510	30	lung	lung	NOUN
admet-2861	510	31	182	182	NUM
admet-2861	510	32	(	(	PUNCT
admet-2861	510	33	2004	2004	NUM
admet-2861	510	34	)	)	PUNCT
admet-2861	510	35	297	297	NUM
admet-2861	510	36	-	-	SYM
admet-2861	510	37	317	317	NUM
admet-2861	510	38	.	.	PUNCT
admet-2861	510	39	https://doi.org/10.1007/s00408-004-2511-6	https://doi.org/10.1007/s00408-004-2511-6	NUM
admet-2861	510	40	.	.	PUNCT
admet-2861	511	1	[	[	X
admet-2861	511	2	38	38	NUM
admet-2861	511	3	]	]	X
admet-2861	511	4	c.b	c.b	PROPN
admet-2861	511	5	.	.	PROPN
admet-2861	511	6	daniels	daniels	PROPN
admet-2861	511	7	,	,	PUNCT
admet-2861	511	8	s.	s.	PROPN
admet-2861	511	9	orgeig	orgeig	PROPN
admet-2861	511	10	.	.	PUNCT
admet-2861	512	1	pulmonary	pulmonary	ADJ
admet-2861	512	2	surfactant	surfactant	NOUN
admet-2861	512	3	:	:	PUNCT
admet-2861	512	4	the	the	DET
admet-2861	512	5	key	key	NOUN
admet-2861	512	6	to	to	ADP
admet-2861	512	7	the	the	DET
admet-2861	512	8	evolution	evolution	NOUN
admet-2861	512	9	of	of	ADP
admet-2861	512	10	air	air	NOUN
admet-2861	512	11	breathing	breathing	NOUN
admet-2861	512	12	.	.	PUNCT
admet-2861	513	1	news	news	NOUN
admet-2861	513	2	in	in	ADP
admet-2861	513	3	physiological	physiological	ADJ
admet-2861	513	4	sciences	science	NOUN
admet-2861	513	5	18	18	NUM
admet-2861	513	6	(	(	PUNCT
admet-2861	513	7	2003	2003	NUM
admet-2861	513	8	)	)	PUNCT
admet-2861	513	9	151	151	NUM
admet-2861	513	10	-	-	SYM
admet-2861	513	11	157	157	NUM
admet-2861	513	12	.	.	PUNCT
admet-2861	514	1	https://doi.org/10.1152/nips.01438.2003	https://doi.org/10.1152/nips.01438.2003	PROPN
admet-2861	514	2	.	.	PUNCT
admet-2861	515	1	[	[	X
admet-2861	515	2	39	39	NUM
admet-2861	515	3	]	]	PUNCT
admet-2861	515	4	e.	e.	PROPN
admet-2861	515	5	innes	innes	PROPN
admet-2861	515	6	,	,	PUNCT
admet-2861	515	7	h.h.p	h.h.p	PROPN
admet-2861	515	8	.	.	PUNCT
admet-2861	515	9	yiu	yiu	PROPN
admet-2861	515	10	,	,	PUNCT
admet-2861	515	11	p.	p.	NOUN
admet-2861	515	12	mclean	mclean	PROPN
admet-2861	515	13	,	,	PUNCT
admet-2861	515	14	w.	w.	PROPN
admet-2861	515	15	brown	brown	PROPN
admet-2861	515	16	,	,	PUNCT
admet-2861	515	17	m.	m.	PROPN
admet-2861	515	18	boyles	boyles	PROPN
admet-2861	515	19	.	.	PUNCT
admet-2861	516	1	simulated	simulate	VERB
admet-2861	516	2	biological	biological	ADJ
admet-2861	516	3	fluids	fluid	NOUN
admet-2861	516	4	–	–	PUNCT
admet-2861	516	5	a	a	DET
admet-2861	516	6	systematic	systematic	ADJ
admet-2861	516	7	review	review	NOUN
admet-2861	516	8	of	of	ADP
admet-2861	516	9	their	their	PRON
admet-2861	516	10	biological	biological	ADJ
admet-2861	516	11	relevance	relevance	NOUN
admet-2861	516	12	and	and	CCONJ
admet-2861	516	13	use	use	NOUN
admet-2861	516	14	in	in	ADP
admet-2861	516	15	relation	relation	NOUN
admet-2861	516	16	to	to	ADP
admet-2861	516	17	inhalation	inhalation	NOUN
admet-2861	516	18	toxicology	toxicology	NOUN
admet-2861	516	19	of	of	ADP
admet-2861	516	20	particles	particle	NOUN
admet-2861	516	21	and	and	CCONJ
admet-2861	516	22	fibres	fibre	NOUN
admet-2861	516	23	.	.	PUNCT
admet-2861	517	1	critical	critical	ADJ
admet-2861	517	2	reviews	review	NOUN
admet-2861	517	3	in	in	ADP
admet-2861	517	4	toxicology	toxicology	NOUN
admet-2861	517	5	51	51	NUM
admet-2861	517	6	(	(	PUNCT
admet-2861	517	7	2021	2021	NUM
admet-2861	517	8	)	)	PUNCT
admet-2861	517	9	217	217	NUM
admet-2861	517	10	-	-	SYM
admet-2861	517	11	248	248	NUM
admet-2861	517	12	.	.	PUNCT
admet-2861	518	1	https://doi.org/10.1080/10408444.2021.1903386	https://doi.org/10.1080/10408444.2021.1903386	PUNCT
admet-2861	518	2	.	.	PUNCT
admet-2861	519	1	[	[	X
admet-2861	519	2	40	40	NUM
admet-2861	519	3	]	]	X
admet-2861	519	4	d.j	d.j	PROPN
admet-2861	519	5	.	.	PROPN
admet-2861	519	6	phillips	phillips	PROPN
admet-2861	519	7	,	,	PUNCT
admet-2861	519	8	s.r	s.r	PROPN
admet-2861	519	9	.	.	PROPN
admet-2861	519	10	pygall	pygall	PROPN
admet-2861	519	11	,	,	PUNCT
admet-2861	519	12	v.b	v.b	PROPN
admet-2861	519	13	.	.	PROPN
admet-2861	519	14	cooper	cooper	PROPN
admet-2861	519	15	,	,	PUNCT
admet-2861	519	16	j.c	j.c	PROPN
admet-2861	519	17	.	.	PROPN
admet-2861	519	18	mann	mann	PROPN
admet-2861	519	19	.	.	PUNCT
admet-2861	520	1	overcoming	overcome	VERB
admet-2861	520	2	sink	sink	NOUN
admet-2861	520	3	limitations	limitation	NOUN
admet-2861	520	4	in	in	ADP
admet-2861	520	5	dissolution	dissolution	ADJ
admet-2861	520	6	testing	testing	NOUN
admet-2861	520	7	:	:	PUNCT
admet-2861	520	8	a	a	DET
admet-2861	520	9	review	review	NOUN
admet-2861	520	10	of	of	ADP
admet-2861	520	11	traditional	traditional	ADJ
admet-2861	520	12	methods	method	NOUN
admet-2861	520	13	and	and	CCONJ
admet-2861	520	14	the	the	DET
admet-2861	520	15	potential	potential	ADJ
admet-2861	520	16	utility	utility	NOUN
admet-2861	520	17	of	of	ADP
admet-2861	520	18	biphasic	biphasic	ADJ
admet-2861	520	19	systems	system	NOUN
admet-2861	520	20	.	.	PUNCT
admet-2861	521	1	journal	journal	NOUN
admet-2861	521	2	of	of	ADP
admet-2861	521	3	pharmacy	pharmacy	NOUN
admet-2861	521	4	and	and	CCONJ
admet-2861	521	5	pharmacology	pharmacology	NOUN
admet-2861	521	6	64	64	NUM
admet-2861	521	7	(	(	PUNCT
admet-2861	521	8	2012	2012	NUM
admet-2861	521	9	)	)	PUNCT
admet-2861	521	10	1549	1549	NUM
admet-2861	521	11	-	-	SYM
admet-2861	521	12	1559	1559	NUM
admet-2861	521	13	.	.	PUNCT
admet-2861	522	1	https://doi.org/10.1111/j.2042-7158.2012.01523.x	https://doi.org/10.1111/j.2042-7158.2012.01523.x	NOUN
admet-2861	522	2	.	.	PUNCT
admet-2861	523	1	[	[	X
admet-2861	523	2	41	41	NUM
admet-2861	523	3	]	]	X
admet-2861	523	4	beclomethasone	beclomethasone	NOUN
admet-2861	523	5	dipropionate	dipropionate	NOUN
admet-2861	523	6	,	,	PUNCT
admet-2861	523	7	https://go.drugbank.com/drugs/db00394	https://go.drugbank.com/drugs/db00394	NOUN
admet-2861	523	8	(	(	PUNCT
admet-2861	523	9	accessed	access	VERB
admet-2861	523	10	18.01.2021	18.01.2021	NUM
admet-2861	523	11	.	.	PUNCT
admet-2861	523	12	)	)	PUNCT
admet-2861	523	13	.	.	PUNCT
admet-2861	524	1	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discriminative_dissolution_method_for_inhalation_preparations	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discriminative_dissolution_method_for_inhalation_preparation	NOUN
admet-2861	524	2	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discriminative_dissolution_method_for_inhalation_preparations	https://www.researchgate.net/publication/333392765_contribution_to_development_of_discriminative_dissolution_method_for_inhalation_preparation	NOUN
admet-2861	524	3	https://doi.org/10.1080/10826076.2011.557464	https://doi.org/10.1080/10826076.2011.557464	PROPN
admet-2861	524	4	https://doi.org/10.1556/achrom.27.2015.2.8	https://doi.org/10.1556/achrom.27.2015.2.8	ADJ
admet-2861	524	5	https://doi.org/10.1046/j.0306-5251.2001.01374.x	https://doi.org/10.1046/j.0306-5251.2001.01374.x	X
admet-2861	525	1	https://doi.org/10.1007/978-3-030-73909-6_74	https://doi.org/10.1007/978-3-030-73909-6_74	PROPN
admet-2861	525	2	https://doi.org/10.1007/s00228-002-0466-1	https://doi.org/10.1007/s00228-002-0466-1	NUM
admet-2861	525	3	https://doi.org/10.1016/j.pupt.2008.01.001	https://doi.org/10.1016/j.pupt.2008.01.001	VERB
admet-2861	525	4	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	NOUN
admet-2861	525	5	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	NOUN
admet-2861	525	6	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-requirements-clinical-documentation-orally-inhaled-products-including-requirements-demonstration-therapeutic-equivalence-between-two-inhaled-products-use-treatment-asthma-chronic-obstructive_en.pdf	PROPN
admet-2861	525	7	https://doi.org/10.1186/s12931-019-0970-9	https://doi.org/10.1186/s12931-019-0970-9	NUM
admet-2861	525	8	https://doi.org/10.1016/s1095-6433(01)00315-4	https://doi.org/10.1016/s1095-6433(01)00315-4	NOUN
admet-2861	525	9	https://doi.org/10.1007/s00408-004-2511-6	https://doi.org/10.1007/s00408-004-2511-6	NUM
admet-2861	526	1	https://doi.org/10.1152/nips.01438.2003	https://doi.org/10.1152/nips.01438.2003	PROPN
admet-2861	526	2	https://doi.org/10.1080/10408444.2021.1903386	https://doi.org/10.1080/10408444.2021.1903386	SCONJ
admet-2861	526	3	https://doi.org/10.1111/j.2042-7158.2012.01523.x	https://doi.org/10.1111/j.2042-7158.2012.01523.x	NOUN
admet-2861	526	4	https://go.drugbank.com/drugs/db00394	https://go.drugbank.com/drugs/db00394	NOUN
admet-2861	526	5	admet	admet	PROPN
admet-2861	526	6	&	&	CCONJ
admet-2861	526	7	dmpk	dmpk	PROPN
admet-2861	526	8	13	13	NUM
admet-2861	526	9	(	(	PUNCT
admet-2861	526	10	)	)	PUNCT
admet-2861	526	11	(	(	PUNCT
admet-2861	526	12	2025	2025	NUM
admet-2861	526	13	)	)	PUNCT
admet-2861	526	14	2861	2861	NUM
admet-2861	526	15	development	development	NOUN
admet-2861	526	16	of	of	ADP
admet-2861	526	17	a	a	DET
admet-2861	526	18	biorelevant	biorelevant	ADJ
admet-2861	526	19	dissolution	dissolution	NOUN
admet-2861	526	20	method	method	NOUN
admet-2861	526	21	for	for	ADP
admet-2861	526	22	inhalation	inhalation	NOUN
admet-2861	526	23	products	product	NOUN
admet-2861	526	24	doi	doi	NOUN
admet-2861	526	25	:	:	PUNCT
admet-2861	526	26	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	526	27	23	23	NUM
admet-2861	526	28	[	[	X
admet-2861	526	29	42	42	NUM
admet-2861	526	30	]	]	PUNCT
admet-2861	526	31	t.	t.	PROPN
admet-2861	526	32	riley	riley	PROPN
admet-2861	526	33	,	,	PUNCT
admet-2861	526	34	d.	d.	PROPN
admet-2861	526	35	christopher	christopher	PROPN
admet-2861	526	36	,	,	PUNCT
admet-2861	526	37	j.	j.	PROPN
admet-2861	526	38	arp	arp	PROPN
admet-2861	526	39	,	,	PUNCT
admet-2861	526	40	a.	a.	NOUN
admet-2861	526	41	casazza	casazza	NOUN
admet-2861	526	42	,	,	PUNCT
admet-2861	526	43	a.	a.	NOUN
admet-2861	526	44	colombani	colombani	PROPN
admet-2861	526	45	,	,	PUNCT
admet-2861	526	46	a.	a.	PROPN
admet-2861	526	47	cooper	cooper	PROPN
admet-2861	526	48	,	,	PUNCT
admet-2861	526	49	m.	m.	PROPN
admet-2861	526	50	dey	dey	PROPN
admet-2861	526	51	,	,	PUNCT
admet-2861	526	52	j.	j.	PROPN
admet-2861	526	53	maas	maas	PROPN
admet-2861	526	54	,	,	PUNCT
admet-2861	526	55	j.	j.	PROPN
admet-2861	526	56	mitchell	mitchell	PROPN
admet-2861	526	57	,	,	PUNCT
admet-2861	526	58	m.	m.	NOUN
admet-2861	526	59	reiners	reiner	NOUN
admet-2861	526	60	,	,	PUNCT
admet-2861	526	61	n.	n.	NOUN
admet-2861	526	62	sigari	sigari	NOUN
admet-2861	526	63	,	,	PUNCT
admet-2861	526	64	t.	t.	NOUN
admet-2861	526	65	tougas	tougas	NOUN
admet-2861	526	66	,	,	PUNCT
admet-2861	526	67	s.	s.	PROPN
admet-2861	526	68	lyapustina	lyapustina	PROPN
admet-2861	526	69	.	.	PUNCT
admet-2861	527	1	challenges	challenge	NOUN
admet-2861	527	2	with	with	ADP
admet-2861	527	3	developing	develop	VERB
admet-2861	527	4	in	in	ADP
admet-2861	527	5	vitro	vitro	X
admet-2861	527	6	dissolution	dissolution	NOUN
admet-2861	527	7	tests	test	NOUN
admet-2861	527	8	for	for	ADP
admet-2861	527	9	orally	orally	ADV
admet-2861	527	10	inhaled	inhaled	ADJ
admet-2861	527	11	products	product	NOUN
admet-2861	527	12	(	(	PUNCT
admet-2861	527	13	oips	oip	NOUN
admet-2861	527	14	)	)	PUNCT
admet-2861	527	15	.	.	PUNCT
admet-2861	528	1	aaps	aap	NOUN
admet-2861	528	2	pharmscitech	pharmscitech	VERB
admet-2861	528	3	13	13	NUM
admet-2861	528	4	(	(	PUNCT
admet-2861	528	5	2012	2012	NUM
admet-2861	528	6	)	)	PUNCT
admet-2861	528	7	978	978	NUM
admet-2861	528	8	-	-	SYM
admet-2861	528	9	989	989	NUM
admet-2861	528	10	.	.	PUNCT
admet-2861	528	11	https://doi.org/10.1208/s12249-012-9822-3	https://doi.org/10.1208/s12249-012-9822-3	NUM
admet-2861	528	12	.	.	PUNCT
admet-2861	529	1	[	[	X
admet-2861	529	2	43	43	NUM
admet-2861	529	3	]	]	X
admet-2861	529	4	j.y.s	j.y.s	NOUN
admet-2861	529	5	.	.	PUNCT
admet-2861	530	1	tay	tay	PROPN
admet-2861	530	2	,	,	PUNCT
admet-2861	530	3	c.v	c.v	PROPN
admet-2861	530	4	.	.	PROPN
admet-2861	530	5	liew	liew	PROPN
admet-2861	530	6	,	,	PUNCT
admet-2861	530	7	p.w.s	p.w.s	NOUN
admet-2861	530	8	.	.	PUNCT
admet-2861	531	1	heng	heng	PROPN
admet-2861	531	2	.	.	PUNCT
admet-2861	532	1	dissolution	dissolution	PROPN
admet-2861	532	2	of	of	ADP
admet-2861	532	3	fine	fine	ADJ
admet-2861	532	4	particle	particle	NOUN
admet-2861	532	5	fraction	fraction	NOUN
admet-2861	532	6	from	from	ADP
admet-2861	532	7	truncated	truncate	VERB
admet-2861	532	8	anderson	anderson	PROPN
admet-2861	532	9	cascade	cascade	NOUN
admet-2861	532	10	impactor	impactor	NOUN
admet-2861	532	11	with	with	ADP
admet-2861	532	12	an	an	DET
admet-2861	532	13	enhancer	enhancer	NOUN
admet-2861	532	14	cell	cell	NOUN
admet-2861	532	15	.	.	PUNCT
admet-2861	533	1	international	international	ADJ
admet-2861	533	2	journal	journal	PROPN
admet-2861	533	3	of	of	ADP
admet-2861	533	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	533	5	545	545	NUM
admet-2861	533	6	(	(	PUNCT
admet-2861	533	7	2018	2018	NUM
admet-2861	533	8	)	)	PUNCT
admet-2861	533	9	45	45	NUM
admet-2861	533	10	-	-	SYM
admet-2861	533	11	50	50	NUM
admet-2861	533	12	.	.	PUNCT
admet-2861	534	1	https://doi.org/10.1016/j.ijpharm.2018.04.048	https://doi.org/10.1016/j.ijpharm.2018.04.048	NOUN
admet-2861	534	2	.	.	PUNCT
admet-2861	535	1	[	[	X
admet-2861	535	2	44	44	NUM
admet-2861	535	3	]	]	X
admet-2861	535	4	j.v	j.v	PROPN
admet-2861	535	5	.	.	PUNCT
admet-2861	535	6	fahy	fahy	PROPN
admet-2861	535	7	,	,	PUNCT
admet-2861	535	8	b.f	b.f	PROPN
admet-2861	535	9	.	.	PROPN
admet-2861	535	10	dickey	dickey	PROPN
admet-2861	535	11	.	.	PROPN
admet-2861	536	1	airway	airway	PROPN
admet-2861	536	2	mucus	mucus	NOUN
admet-2861	536	3	function	function	NOUN
admet-2861	536	4	and	and	CCONJ
admet-2861	536	5	dysfunction	dysfunction	NOUN
admet-2861	536	6	.	.	PUNCT
admet-2861	537	1	the	the	DET
admet-2861	537	2	new	new	PROPN
admet-2861	537	3	england	england	PROPN
admet-2861	537	4	journal	journal	PROPN
admet-2861	537	5	of	of	ADP
admet-2861	537	6	medicine	medicine	NOUN
admet-2861	537	7	363	363	NUM
admet-2861	537	8	(	(	PUNCT
admet-2861	537	9	2010	2010	NUM
admet-2861	537	10	)	)	PUNCT
admet-2861	537	11	2233	2233	NUM
admet-2861	537	12	-	-	SYM
admet-2861	537	13	2247	2247	NUM
admet-2861	537	14	.	.	PUNCT
admet-2861	538	1	https://doi.org/10.1056/nejmra0910061	https://doi.org/10.1056/nejmra0910061	PROPN
admet-2861	538	2	.	.	PUNCT
admet-2861	539	1	[	[	X
admet-2861	539	2	45	45	NUM
admet-2861	539	3	]	]	X
admet-2861	539	4	j.	j.	PROPN
admet-2861	539	5	varshosaz	varshosaz	PROPN
admet-2861	539	6	,	,	PUNCT
admet-2861	539	7	m.r	m.r	PROPN
admet-2861	539	8	.	.	PROPN
admet-2861	539	9	zaki	zaki	PROPN
admet-2861	539	10	,	,	PUNCT
admet-2861	539	11	m.	m.	NOUN
admet-2861	539	12	minaiyan	minaiyan	PROPN
admet-2861	539	13	,	,	PUNCT
admet-2861	539	14	j.	j.	PROPN
admet-2861	539	15	banoozadeh	banoozadeh	PROPN
admet-2861	539	16	.	.	PUNCT
admet-2861	540	1	preparation	preparation	NOUN
admet-2861	540	2	,	,	PUNCT
admet-2861	540	3	optimization	optimization	NOUN
admet-2861	540	4	,	,	PUNCT
admet-2861	540	5	and	and	CCONJ
admet-2861	540	6	screening	screening	NOUN
admet-2861	540	7	of	of	ADP
admet-2861	540	8	the	the	DET
admet-2861	540	9	effect	effect	NOUN
admet-2861	540	10	of	of	ADP
admet-2861	540	11	processing	processing	NOUN
admet-2861	540	12	variables	variable	NOUN
admet-2861	540	13	on	on	ADP
admet-2861	540	14	agar	agar	NOUN
admet-2861	540	15	nanospheres	nanosphere	NOUN
admet-2861	540	16	loaded	load	VERB
admet-2861	540	17	with	with	ADP
admet-2861	540	18	bupropion	bupropion	NOUN
admet-2861	540	19	hcl	hcl	PROPN
admet-2861	540	20	by	by	ADP
admet-2861	540	21	a	a	DET
admet-2861	540	22	d	d	ADJ
admet-2861	540	23	-	-	ADJ
admet-2861	540	24	optimal	optimal	ADJ
admet-2861	540	25	design	design	NOUN
admet-2861	540	26	.	.	PUNCT
admet-2861	540	27	biomed	biome	VERB
admet-2861	540	28	research	research	NOUN
admet-2861	540	29	international	international	ADJ
admet-2861	540	30	2015	2015	NUM
admet-2861	540	31	(	(	PUNCT
admet-2861	540	32	2015	2015	NUM
admet-2861	540	33	)	)	PUNCT
admet-2861	540	34	571816	571816	NUM
admet-2861	540	35	.	.	PUNCT
admet-2861	541	1	https://doi.org/10.1155/2015/571816	https://doi.org/10.1155/2015/571816	PROPN
admet-2861	541	2	.	.	PUNCT
admet-2861	542	1	[	[	X
admet-2861	542	2	46	46	NUM
admet-2861	542	3	]	]	X
admet-2861	542	4	d.s	d.s	PROPN
admet-2861	542	5	.	.	PROPN
admet-2861	542	6	conti	conti	PROPN
admet-2861	542	7	,	,	PUNCT
admet-2861	542	8	j.	j.	PROPN
admet-2861	542	9	grashik	grashik	PROPN
admet-2861	542	10	,	,	PUNCT
admet-2861	542	11	l.	l.	PROPN
admet-2861	542	12	yang	yang	PROPN
admet-2861	542	13	,	,	PUNCT
admet-2861	542	14	l.	l.	PROPN
admet-2861	542	15	wu	wu	PROPN
admet-2861	542	16	,	,	PUNCT
admet-2861	542	17	s.r.p	s.r.p	NOUN
admet-2861	542	18	.	.	PUNCT
admet-2861	542	19	da	da	PROPN
admet-2861	542	20	rocha	rocha	PROPN
admet-2861	542	21	.	.	PUNCT
admet-2861	543	1	solvation	solvation	NOUN
admet-2861	543	2	in	in	ADP
admet-2861	543	3	hydrofluoroalkanes	hydrofluoroalkane	NOUN
admet-2861	543	4	:	:	PUNCT
admet-2861	543	5	how	how	SCONJ
admet-2861	543	6	can	can	AUX
admet-2861	543	7	ethanol	ethanol	VERB
admet-2861	543	8	help	help	NOUN
admet-2861	543	9	?	?	PUNCT
admet-2861	544	1	journal	journal	NOUN
admet-2861	544	2	of	of	ADP
admet-2861	544	3	pharmacy	pharmacy	NOUN
admet-2861	544	4	and	and	CCONJ
admet-2861	544	5	pharmacology	pharmacology	NOUN
admet-2861	544	6	64	64	NUM
admet-2861	544	7	(	(	PUNCT
admet-2861	544	8	2012	2012	NUM
admet-2861	544	9	)	)	PUNCT
admet-2861	544	10	1236	1236	NUM
admet-2861	544	11	-	-	SYM
admet-2861	544	12	1244	1244	NUM
admet-2861	544	13	.	.	PUNCT
admet-2861	545	1	https://doi.org/10.1111/j.2042-7158.2011.01398.x	https://doi.org/10.1111/j.2042-7158.2011.01398.x	NOUN
admet-2861	545	2	.	.	PUNCT
admet-2861	546	1	[	[	X
admet-2861	546	2	47	47	NUM
admet-2861	546	3	]	]	X
admet-2861	546	4	g.t	g.t	PROPN
admet-2861	546	5	.	.	PROPN
admet-2861	546	6	ferguson	ferguson	PROPN
admet-2861	546	7	,	,	PUNCT
admet-2861	546	8	a.j	a.j	PROPN
admet-2861	546	9	.	.	PROPN
admet-2861	546	10	hickey	hickey	PROPN
admet-2861	546	11	,	,	PUNCT
admet-2861	546	12	s.	s.	PROPN
admet-2861	546	13	dwivedi	dwivedi	PROPN
admet-2861	546	14	.	.	PUNCT
admet-2861	547	1	co	co	NOUN
admet-2861	547	2	-	-	NOUN
admet-2861	547	3	suspension	suspension	NOUN
admet-2861	547	4	delivery	delivery	NOUN
admet-2861	547	5	technology	technology	NOUN
admet-2861	547	6	in	in	ADP
admet-2861	547	7	pressurized	pressurized	ADJ
admet-2861	547	8	metereddose	metereddose	NOUN
admet-2861	547	9	inhalers	inhaler	NOUN
admet-2861	547	10	for	for	ADP
admet-2861	547	11	multi	multi	ADJ
admet-2861	547	12	-	-	ADJ
admet-2861	547	13	drug	drug	ADJ
admet-2861	547	14	dosing	dosing	NOUN
admet-2861	547	15	in	in	ADP
admet-2861	547	16	the	the	DET
admet-2861	547	17	treatment	treatment	NOUN
admet-2861	547	18	of	of	ADP
admet-2861	547	19	respiratory	respiratory	ADJ
admet-2861	547	20	diseases	disease	NOUN
admet-2861	547	21	.	.	PUNCT
admet-2861	548	1	respiratory	respiratory	ADJ
admet-2861	548	2	medicine	medicine	NOUN
admet-2861	548	3	134	134	NUM
admet-2861	548	4	(	(	PUNCT
admet-2861	548	5	2018	2018	NUM
admet-2861	548	6	)	)	PUNCT
admet-2861	548	7	16	16	NUM
admet-2861	548	8	-	-	SYM
admet-2861	548	9	23	23	NUM
admet-2861	548	10	.	.	PUNCT
admet-2861	549	1	https://doi.org/10.1016/j.rmed.2017.09.012	https://doi.org/10.1016/j.rmed.2017.09.012	PROPN
admet-2861	550	1	[	[	X
admet-2861	550	2	48	48	NUM
admet-2861	550	3	]	]	PUNCT
admet-2861	550	4	a.	a.	NOUN
admet-2861	550	5	theophilus	theophilus	PROPN
admet-2861	550	6	,	,	PUNCT
admet-2861	550	7	a.	a.	PROPN
admet-2861	550	8	moore	moore	PROPN
admet-2861	550	9	,	,	PUNCT
admet-2861	550	10	d.	d.	PROPN
admet-2861	550	11	prime	prime	PROPN
admet-2861	550	12	,	,	PUNCT
admet-2861	550	13	s.	s.	PROPN
admet-2861	550	14	rossomanno	rossomanno	PROPN
admet-2861	550	15	,	,	PUNCT
admet-2861	550	16	b.	b.	PROPN
admet-2861	550	17	whitcher	whitcher	PROPN
admet-2861	550	18	,	,	PUNCT
admet-2861	550	19	h.	h.	PROPN
admet-2861	550	20	chrystyn	chrystyn	PROPN
admet-2861	550	21	.	.	PUNCT
admet-2861	551	1	co	co	NOUN
admet-2861	551	2	-	-	NOUN
admet-2861	551	3	deposition	deposition	NOUN
admet-2861	551	4	of	of	ADP
admet-2861	551	5	salmeterol	salmeterol	NOUN
admet-2861	551	6	and	and	CCONJ
admet-2861	551	7	fluticasone	fluticasone	NOUN
admet-2861	551	8	propionate	propionate	NOUN
admet-2861	551	9	by	by	ADP
admet-2861	551	10	a	a	DET
admet-2861	551	11	combination	combination	NOUN
admet-2861	551	12	inhaler	inhaler	NOUN
admet-2861	551	13	.	.	PUNCT
admet-2861	552	1	international	international	ADJ
admet-2861	552	2	journal	journal	PROPN
admet-2861	552	3	of	of	ADP
admet-2861	552	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	552	5	313	313	NUM
admet-2861	552	6	(	(	PUNCT
admet-2861	552	7	2006	2006	NUM
admet-2861	552	8	)	)	PUNCT
admet-2861	552	9	14	14	NUM
admet-2861	552	10	-	-	SYM
admet-2861	552	11	22	22	NUM
admet-2861	552	12	.	.	PUNCT
admet-2861	553	1	https://doi.org/10.1016/j.ijpharm.2006.01.018	https://doi.org/10.1016/j.ijpharm.2006.01.018	NOUN
admet-2861	554	1	[	[	X
admet-2861	554	2	49	49	NUM
admet-2861	554	3	]	]	PUNCT
admet-2861	554	4	s.	s.	PROPN
admet-2861	554	5	kirchberg	kirchberg	PROPN
admet-2861	554	6	,	,	PUNCT
admet-2861	554	7	y.	y.	PROPN
admet-2861	554	8	abdin	abdin	PROPN
admet-2861	554	9	,	,	PUNCT
admet-2861	554	10	g.	g.	PROPN
admet-2861	554	11	ziegmann	ziegmann	PROPN
admet-2861	554	12	.	.	PUNCT
admet-2861	555	1	influence	influence	NOUN
admet-2861	555	2	of	of	ADP
admet-2861	555	3	particle	particle	NOUN
admet-2861	555	4	shape	shape	NOUN
admet-2861	555	5	and	and	CCONJ
admet-2861	555	6	size	size	NOUN
admet-2861	555	7	on	on	ADP
admet-2861	555	8	the	the	DET
admet-2861	555	9	wetting	wet	VERB
admet-2861	555	10	behavior	behavior	NOUN
admet-2861	555	11	of	of	ADP
admet-2861	555	12	soft	soft	ADJ
admet-2861	555	13	magnetic	magnetic	ADJ
admet-2861	555	14	micropowders	micropowder	NOUN
admet-2861	555	15	.	.	PUNCT
admet-2861	556	1	powder	powder	NOUN
admet-2861	556	2	technology	technology	NOUN
admet-2861	556	3	207	207	NUM
admet-2861	556	4	(	(	PUNCT
admet-2861	556	5	2011	2011	NUM
admet-2861	556	6	)	)	PUNCT
admet-2861	556	7	311	311	NUM
admet-2861	556	8	-	-	SYM
admet-2861	556	9	317	317	NUM
admet-2861	556	10	.	.	PUNCT
admet-2861	557	1	https://doi.org/10.1016/j.powtec.2010.11.012	https://doi.org/10.1016/j.powtec.2010.11.012	PROPN
admet-2861	557	2	[	[	X
admet-2861	557	3	50	50	NUM
admet-2861	557	4	]	]	PUNCT
admet-2861	557	5	n.	n.	PROPN
admet-2861	557	6	yongjian	yongjian	PROPN
admet-2861	557	7	,	,	PUNCT
admet-2861	557	8	y.	y.	PROPN
admet-2861	557	9	lan	lan	PROPN
admet-2861	557	10	,	,	PUNCT
admet-2861	557	11	z.	z.	PROPN
admet-2861	557	12	shijie	shijie	PROPN
admet-2861	557	13	,	,	PUNCT
admet-2861	557	14	c.	c.	PROPN
admet-2861	557	15	xueli	xueli	PROPN
admet-2861	557	16	.	.	PUNCT
admet-2861	558	1	wettability	wettability	NOUN
admet-2861	558	2	of	of	ADP
admet-2861	558	3	fine	fine	ADJ
admet-2861	558	4	ash	ash	NOUN
admet-2861	558	5	from	from	ADP
admet-2861	558	6	opposed	opposed	ADJ
admet-2861	558	7	multi	multi	ADJ
admet-2861	558	8	-	-	ADJ
admet-2861	558	9	burner	burner	ADJ
admet-2861	558	10	coal	coal	NOUN
admet-2861	558	11	water	water	NOUN
admet-2861	558	12	slurry	slurry	NOUN
admet-2861	558	13	gasification	gasification	NOUN
admet-2861	558	14	journal	journal	PROPN
admet-2861	558	15	of	of	ADP
admet-2861	558	16	east	east	PROPN
admet-2861	558	17	china	china	PROPN
admet-2861	558	18	university	university	PROPN
admet-2861	558	19	of	of	ADP
admet-2861	558	20	science	science	NOUN
admet-2861	558	21	and	and	CCONJ
admet-2861	558	22	technology	technology	NOUN
admet-2861	558	23	47	47	NUM
admet-2861	558	24	(	(	PUNCT
admet-2861	558	25	2021	2021	NUM
admet-2861	558	26	)	)	PUNCT
admet-2861	558	27	408	408	NUM
admet-2861	558	28	-	-	SYM
admet-2861	558	29	413	413	NUM
admet-2861	558	30	.	.	PUNCT
admet-2861	558	31	https://link.oversea.cnki.net/doi/10.14135/j.cnki.1006-3080.20200328001	https://link.oversea.cnki.net/doi/10.14135/j.cnki.1006-3080.20200328001	X
admet-2861	559	1	[	[	X
admet-2861	559	2	51	51	NUM
admet-2861	559	3	]	]	X
admet-2861	559	4	c.f	c.f	PROPN
admet-2861	559	5	.	.	PROPN
admet-2861	559	6	lerk	lerk	PROPN
admet-2861	559	7	,	,	PUNCT
admet-2861	559	8	a.j	a.j	PROPN
admet-2861	559	9	.	.	PROPN
admet-2861	559	10	schoonen	schoonen	PROPN
admet-2861	559	11	,	,	PUNCT
admet-2861	559	12	j.t	j.t	PROPN
admet-2861	559	13	.	.	PROPN
admet-2861	559	14	fell	fall	VERB
admet-2861	559	15	.	.	PUNCT
admet-2861	560	1	contact	contact	NOUN
admet-2861	560	2	angles	angle	NOUN
admet-2861	560	3	and	and	CCONJ
admet-2861	560	4	wetting	wetting	NOUN
admet-2861	560	5	of	of	ADP
admet-2861	560	6	pharmaceutical	pharmaceutical	NOUN
admet-2861	560	7	powders	powder	NOUN
admet-2861	560	8	.	.	PUNCT
admet-2861	561	1	journal	journal	PROPN
admet-2861	561	2	of	of	ADP
admet-2861	561	3	pharmaceutical	pharmaceutical	PROPN
admet-2861	561	4	sciences	science	NOUN
admet-2861	561	5	65	65	NUM
admet-2861	561	6	(	(	PUNCT
admet-2861	561	7	1976	1976	NUM
admet-2861	561	8	):	):	PUNCT
admet-2861	561	9	843	843	NUM
admet-2861	561	10	-	-	SYM
admet-2861	561	11	847	847	NUM
admet-2861	561	12	.	.	PUNCT
admet-2861	562	1	https://doi.org/10.1002/jps.2600650611	https://doi.org/10.1002/jps.2600650611	NOUN
admet-2861	562	2	.	.	PUNCT
admet-2861	563	1	[	[	X
admet-2861	563	2	52	52	NUM
admet-2861	563	3	]	]	PUNCT
admet-2861	563	4	j.	j.	PROPN
admet-2861	563	5	eriksson	eriksson	PROPN
admet-2861	563	6	,	,	PUNCT
admet-2861	563	7	e.	e.	PROPN
admet-2861	563	8	sjögren	sjögren	PROPN
admet-2861	563	9	,	,	PUNCT
admet-2861	563	10	h.	h.	PROPN
admet-2861	563	11	thörn	thörn	PROPN
admet-2861	563	12	,	,	PUNCT
admet-2861	563	13	k.	k.	PROPN
admet-2861	563	14	rubin	rubin	PROPN
admet-2861	563	15	,	,	PUNCT
admet-2861	563	16	p.	p.	PROPN
admet-2861	563	17	bäckman	bäckman	PROPN
admet-2861	563	18	,	,	PUNCT
admet-2861	563	19	h.	h.	PROPN
admet-2861	563	20	lennernäs	lennernäs	PROPN
admet-2861	563	21	.	.	PUNCT
admet-2861	564	1	pulmonary	pulmonary	ADJ
admet-2861	564	2	absorption	absorption	NOUN
admet-2861	564	3	–	–	PUNCT
admet-2861	564	4	estimation	estimation	NOUN
admet-2861	564	5	of	of	ADP
admet-2861	564	6	effective	effective	ADJ
admet-2861	564	7	pulmonary	pulmonary	ADJ
admet-2861	564	8	permeability	permeability	NOUN
admet-2861	564	9	and	and	CCONJ
admet-2861	564	10	tissue	tissue	NOUN
admet-2861	564	11	retention	retention	NOUN
admet-2861	564	12	of	of	ADP
admet-2861	564	13	ten	ten	NUM
admet-2861	564	14	drugs	drug	NOUN
admet-2861	564	15	using	use	VERB
admet-2861	564	16	an	an	DET
admet-2861	564	17	ex	ex	ADJ
admet-2861	564	18	vivo	vivo	ADJ
admet-2861	564	19	rat	rat	NOUN
admet-2861	564	20	model	model	NOUN
admet-2861	564	21	and	and	CCONJ
admet-2861	564	22	computational	computational	ADJ
admet-2861	564	23	analysis	analysis	NOUN
admet-2861	564	24	.	.	PUNCT
admet-2861	565	1	european	european	ADJ
admet-2861	565	2	journal	journal	PROPN
admet-2861	565	3	of	of	ADP
admet-2861	565	4	pharmaceutics	pharmaceutic	NOUN
admet-2861	565	5	and	and	CCONJ
admet-2861	565	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2861	565	7	124	124	NUM
admet-2861	565	8	(	(	PUNCT
admet-2861	565	9	2018	2018	NUM
admet-2861	565	10	)	)	PUNCT
admet-2861	565	11	1	1	NUM
admet-2861	565	12	-	-	SYM
admet-2861	565	13	12	12	NUM
admet-2861	565	14	.	.	PUNCT
admet-2861	566	1	https://doi.org/10.1016/j.ejpb.2017.11.013	https://doi.org/10.1016/j.ejpb.2017.11.013	NOUN
admet-2861	567	1	[	[	X
admet-2861	567	2	53	53	NUM
admet-2861	567	3	]	]	PUNCT
admet-2861	567	4	w.	w.	NOUN
admet-2861	567	5	möller	möller	PROPN
admet-2861	567	6	,	,	PUNCT
admet-2861	567	7	k.	k.	PROPN
admet-2861	567	8	häussinger	häussinger	PROPN
admet-2861	567	9	,	,	PUNCT
admet-2861	567	10	l.	l.	PROPN
admet-2861	567	11	ziegler	ziegler	PROPN
admet-2861	567	12	-	-	PROPN
admet-2861	567	13	heitbrock	heitbrock	PROPN
admet-2861	567	14	,	,	PUNCT
admet-2861	567	15	j.	j.	PROPN
admet-2861	567	16	heyder	heyder	PROPN
admet-2861	567	17	.	.	PUNCT
admet-2861	568	1	mucociliary	mucociliary	NOUN
admet-2861	568	2	and	and	CCONJ
admet-2861	568	3	long	long	ADJ
admet-2861	568	4	-	-	PUNCT
admet-2861	568	5	term	term	NOUN
admet-2861	568	6	particle	particle	NOUN
admet-2861	568	7	clearance	clearance	NOUN
admet-2861	568	8	in	in	ADP
admet-2861	568	9	airways	airway	NOUN
admet-2861	568	10	of	of	ADP
admet-2861	568	11	patients	patient	NOUN
admet-2861	568	12	with	with	ADP
admet-2861	568	13	immotile	immotile	ADJ
admet-2861	568	14	cilia	cilium	NOUN
admet-2861	568	15	.	.	PUNCT
admet-2861	569	1	respiratory	respiratory	ADJ
admet-2861	569	2	research	research	NOUN
admet-2861	569	3	7	7	NUM
admet-2861	569	4	(	(	PUNCT
admet-2861	569	5	2006	2006	NUM
admet-2861	569	6	)	)	PUNCT
admet-2861	569	7	10	10	NUM
admet-2861	569	8	.	.	PUNCT
admet-2861	570	1	https://doi.org/10.1186/1465-9921-7-10	https://doi.org/10.1186/1465-9921-7-10	X
admet-2861	570	2	.	.	PUNCT
admet-2861	571	1	[	[	X
admet-2861	571	2	54	54	NUM
admet-2861	571	3	]	]	X
admet-2861	571	4	r.	r.	NOUN
admet-2861	571	5	price	price	PROPN
admet-2861	571	6	,	,	PUNCT
admet-2861	571	7	j.	j.	PROPN
admet-2861	571	8	shur	shur	PROPN
admet-2861	571	9	,	,	PUNCT
admet-2861	571	10	w.	w.	NOUN
admet-2861	571	11	ganley	ganley	PROPN
admet-2861	571	12	,	,	PUNCT
admet-2861	571	13	g.	g.	PROPN
admet-2861	571	14	farias	farias	PROPN
admet-2861	571	15	,	,	PUNCT
admet-2861	571	16	n.	n.	PROPN
admet-2861	571	17	fotaki	fotaki	PROPN
admet-2861	571	18	,	,	PUNCT
admet-2861	571	19	d.s	d.s	PROPN
admet-2861	571	20	.	.	PROPN
admet-2861	571	21	conti	conti	PROPN
admet-2861	571	22	,	,	PUNCT
admet-2861	571	23	r.	r.	PROPN
admet-2861	571	24	delvadia	delvadia	PROPN
admet-2861	571	25	,	,	PUNCT
admet-2861	571	26	m.	m.	NOUN
admet-2861	571	27	absar	absar	PROPN
admet-2861	571	28	,	,	PUNCT
admet-2861	571	29	b.	b.	PROPN
admet-2861	571	30	saluja	saluja	PROPN
admet-2861	571	31	,	,	PUNCT
admet-2861	571	32	s.	s.	PROPN
admet-2861	571	33	lee	lee	PROPN
admet-2861	571	34	.	.	PROPN
admet-2861	572	1	development	development	PROPN
admet-2861	572	2	of	of	ADP
admet-2861	572	3	an	an	DET
admet-2861	572	4	aerosol	aerosol	NOUN
admet-2861	572	5	dose	dose	VERB
admet-2861	572	6	collection	collection	NOUN
admet-2861	572	7	apparatus	apparatus	NOUN
admet-2861	572	8	for	for	ADP
admet-2861	572	9	in	in	ADP
admet-2861	572	10	vitro	vitro	X
admet-2861	572	11	dissolution	dissolution	ADJ
admet-2861	572	12	measurements	measurement	NOUN
admet-2861	572	13	of	of	ADP
admet-2861	572	14	orally	orally	ADV
admet-2861	572	15	inhaled	inhale	VERB
admet-2861	572	16	drug	drug	NOUN
admet-2861	572	17	products	product	NOUN
admet-2861	572	18	.	.	PUNCT
admet-2861	573	1	aaps	aap	NOUN
admet-2861	573	2	journal	journal	PROPN
admet-2861	573	3	22	22	NUM
admet-2861	573	4	(	(	PUNCT
admet-2861	573	5	2020	2020	NUM
admet-2861	573	6	)	)	PUNCT
admet-2861	573	7	47	47	NUM
admet-2861	573	8	.	.	PUNCT
admet-2861	574	1	https://doi.org/10.1208/s12248-020-0422-y	https://doi.org/10.1208/s12248-020-0422-y	INTJ
admet-2861	574	2	.	.	PUNCT
admet-2861	575	1	[	[	X
admet-2861	575	2	55	55	NUM
admet-2861	575	3	]	]	PUNCT
admet-2861	575	4	beclomethasone	beclomethasone	VERB
admet-2861	575	5	17	17	NUM
admet-2861	575	6	-	-	PUNCT
admet-2861	575	7	monopropionate	monopropionate	NOUN
admet-2861	575	8	,	,	PUNCT
admet-2861	575	9	https://go.drugbank.com/drugs/db14221	https://go.drugbank.com/drugs/db14221	NOUN
admet-2861	575	10	(	(	PUNCT
admet-2861	575	11	accessed	access	VERB
admet-2861	575	12	:	:	PUNCT
admet-2861	575	13	18.01.2021	18.01.2021	NUM
admet-2861	575	14	.	.	PUNCT
admet-2861	575	15	)	)	PUNCT
admet-2861	575	16	.	.	PUNCT
admet-2861	576	1	[	[	X
admet-2861	576	2	56	56	NUM
admet-2861	576	3	]	]	X
admet-2861	576	4	beclomethasone	beclomethasone	NOUN
admet-2861	576	5	dipropionate	dipropionate	NOUN
admet-2861	576	6	,	,	PUNCT
admet-2861	576	7	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasonedipropionate	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasonedipropionate	X
admet-2861	576	8	.	.	PUNCT
admet-2861	577	1	(	(	PUNCT
admet-2861	577	2	accessed	access	VERB
admet-2861	577	3	:	:	PUNCT
admet-2861	577	4	18.01.2021	18.01.2021	NUM
admet-2861	577	5	.	.	PUNCT
admet-2861	577	6	)	)	PUNCT
admet-2861	577	7	.	.	PUNCT
admet-2861	578	1	[	[	X
admet-2861	578	2	57	57	NUM
admet-2861	578	3	]	]	SYM
admet-2861	578	4	a.r	a.r	PROPN
admet-2861	578	5	.	.	PROPN
admet-2861	578	6	boobis	boobis	PROPN
admet-2861	578	7	.	.	PUNCT
admet-2861	579	1	comparative	comparative	ADJ
admet-2861	579	2	physicochemical	physicochemical	ADJ
admet-2861	579	3	and	and	CCONJ
admet-2861	579	4	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	579	5	profiles	profile	NOUN
admet-2861	579	6	of	of	ADP
admet-2861	579	7	inhaled	inhaled	ADJ
admet-2861	579	8	beclomethasone	beclomethasone	ADJ
admet-2861	579	9	dipropionate	dipropionate	NOUN
admet-2861	579	10	and	and	CCONJ
admet-2861	579	11	budesonide	budesonide	NOUN
admet-2861	579	12	.	.	PUNCT
admet-2861	580	1	respiratory	respiratory	ADJ
admet-2861	580	2	medicine	medicine	NOUN
admet-2861	580	3	92	92	NUM
admet-2861	580	4	(	(	PUNCT
admet-2861	580	5	1998	1998	NUM
admet-2861	580	6	)	)	PUNCT
admet-2861	580	7	2	2	NUM
admet-2861	580	8	-	-	SYM
admet-2861	580	9	6	6	NUM
admet-2861	580	10	.	.	PUNCT
admet-2861	581	1	https://doi.org/10.1016/s09546111(98)90434-6	https://doi.org/10.1016/s09546111(98)90434-6	NOUN
admet-2861	582	1	[	[	X
admet-2861	582	2	58	58	NUM
admet-2861	582	3	]	]	X
admet-2861	582	4	j.a	j.a	PROPN
admet-2861	582	5	.	.	PROPN
admet-2861	582	6	yáñez	yáñez	PROPN
admet-2861	582	7	,	,	PUNCT
admet-2861	582	8	c.m	c.m	PROPN
admet-2861	582	9	.	.	PROPN
admet-2861	582	10	remsberg	remsberg	PROPN
admet-2861	582	11	,	,	PUNCT
admet-2861	583	1	c.l	c.l	PROPN
admet-2861	583	2	.	.	PROPN
admet-2861	583	3	sayre	sayre	PROPN
admet-2861	583	4	,	,	PUNCT
admet-2861	583	5	m.l	m.l	PROPN
admet-2861	583	6	.	.	PUNCT
admet-2861	583	7	forrest	forrest	PROPN
admet-2861	583	8	,	,	PUNCT
admet-2861	583	9	n.m	n.m	PROPN
admet-2861	583	10	.	.	PROPN
admet-2861	583	11	davies	davy	NOUN
admet-2861	583	12	.	.	PUNCT
admet-2861	584	1	flip	flip	NOUN
admet-2861	584	2	-	-	PUNCT
admet-2861	584	3	flop	flop	VERB
admet-2861	584	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2861	584	5	-	-	PUNCT
admet-2861	584	6	delivering	deliver	VERB
admet-2861	584	7	a	a	DET
admet-2861	584	8	reversal	reversal	NOUN
admet-2861	584	9	of	of	ADP
admet-2861	584	10	disposition	disposition	NOUN
admet-2861	584	11	:	:	PUNCT
admet-2861	584	12	challenges	challenge	NOUN
admet-2861	584	13	and	and	CCONJ
admet-2861	584	14	opportunities	opportunity	NOUN
admet-2861	584	15	during	during	ADP
admet-2861	584	16	drug	drug	NOUN
admet-2861	584	17	development	development	NOUN
admet-2861	584	18	.	.	PUNCT
admet-2861	585	1	therapeutic	therapeutic	ADJ
admet-2861	585	2	delivery	delivery	NOUN
admet-2861	585	3	2	2	NUM
admet-2861	585	4	(	(	PUNCT
admet-2861	585	5	2011	2011	NUM
admet-2861	585	6	)	)	PUNCT
admet-2861	585	7	643	643	NUM
admet-2861	585	8	-	-	SYM
admet-2861	585	9	672	672	NUM
admet-2861	585	10	.	.	PUNCT
admet-2861	586	1	https://doi.org/10.4155/tde.11.19	https://doi.org/10.4155/tde.11.19	NOUN
admet-2861	586	2	.	.	PUNCT
admet-2861	587	1	https://doi.org/10.5599/admet.2861	https://doi.org/10.5599/admet.2861	NOUN
admet-2861	587	2	https://doi.org/10.1208/s12249-012-9822-3	https://doi.org/10.1208/s12249-012-9822-3	NUM
admet-2861	587	3	https://doi.org/10.1016/j.ijpharm.2018.04.048	https://doi.org/10.1016/j.ijpharm.2018.04.048	PROPN
admet-2861	587	4	https://doi.org/10.1056/nejmra0910061	https://doi.org/10.1056/nejmra0910061	PROPN
admet-2861	588	1	https://doi.org/10.1155/2015/571816	https://doi.org/10.1155/2015/571816	PROPN
admet-2861	588	2	https://doi.org/10.1111/j.2042-7158.2011.01398.x	https://doi.org/10.1111/j.2042-7158.2011.01398.x	VERB
admet-2861	588	3	https://doi.org/10.1016/j.rmed.2017.09.012	https://doi.org/10.1016/j.rmed.2017.09.012	PROPN
admet-2861	588	4	https://doi.org/10.1016/j.ijpharm.2006.01.018	https://doi.org/10.1016/j.ijpharm.2006.01.018	PROPN
admet-2861	588	5	https://doi.org/10.1016/j.powtec.2010.11.012	https://doi.org/10.1016/j.powtec.2010.11.012	PROPN
admet-2861	588	6	https://link.oversea.cnki.net/doi/10.14135/j.cnki.1006-3080.20200328001	https://link.oversea.cnki.net/doi/10.14135/j.cnki.1006-3080.20200328001	NOUN
admet-2861	588	7	https://doi.org/10.1002/jps.2600650611	https://doi.org/10.1002/jps.2600650611	PROPN
admet-2861	588	8	https://doi.org/10.1016/j.ejpb.2017.11.013	https://doi.org/10.1016/j.ejpb.2017.11.013	NOUN
admet-2861	588	9	https://doi.org/10.1186/1465-9921-7-10	https://doi.org/10.1186/1465-9921-7-10	X
admet-2861	588	10	https://doi.org/10.1208/s12248-020-0422-y	https://doi.org/10.1208/s12248-020-0422-y	PRON
admet-2861	588	11	https://go.drugbank.com/drugs/db14221	https://go.drugbank.com/drugs/db14221	NOUN
admet-2861	588	12	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasone-dipropionate	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasone-dipropionate	NOUN
admet-2861	588	13	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasone-dipropionate	https://pubchem.ncbi.nlm.nih.gov/compound/beclomethasone-dipropionate	NOUN
admet-2861	588	14	https://doi.org/10.1016/s0954-6111(98)90434-6	https://doi.org/10.1016/s0954-6111(98)90434-6	NOUN
admet-2861	588	15	https://doi.org/10.1016/s0954-6111(98)90434-6	https://doi.org/10.1016/s0954-6111(98)90434-6	NOUN
admet-2861	589	1	https://doi.org/10.4155/tde.11.19	https://doi.org/10.4155/tde.11.19	PROPN
admet-2861	589	2	a.	a.	NOUN
admet-2861	589	3	elezović	elezović	PROPN
admet-2861	589	4	et	et	PROPN
admet-2861	589	5	al	al	PROPN
admet-2861	589	6	.	.	PROPN
admet-2861	589	7	admet	admet	PROPN
admet-2861	589	8	&	&	CCONJ
admet-2861	589	9	dmpk	dmpk	PROPN
admet-2861	589	10	13(5	13(5	NUM
admet-2861	589	11	)	)	PUNCT
admet-2861	589	12	(	(	PUNCT
admet-2861	589	13	2025	2025	NUM
admet-2861	589	14	)	)	PUNCT
admet-2861	589	15	2861	2861	NUM
admet-2861	589	16	24	24	NUM
admet-2861	590	1	[	[	X
admet-2861	590	2	59	59	NUM
admet-2861	590	3	]	]	PUNCT
admet-2861	590	4	h.	h.	PROPN
admet-2861	590	5	boxenbaum	boxenbaum	PROPN
admet-2861	590	6	.	.	PUNCT
admet-2861	591	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2861	591	2	tricks	trick	NOUN
admet-2861	591	3	and	and	CCONJ
admet-2861	591	4	traps	trap	NOUN
admet-2861	591	5	:	:	PUNCT
admet-2861	591	6	flip	flip	NOUN
admet-2861	591	7	-	-	PUNCT
admet-2861	591	8	flop	flop	NOUN
admet-2861	591	9	models	model	NOUN
admet-2861	591	10	.	.	PUNCT
admet-2861	592	1	journal	journal	NOUN
admet-2861	592	2	of	of	ADP
admet-2861	592	3	pharmacy	pharmacy	NOUN
admet-2861	592	4	and	and	CCONJ
admet-2861	592	5	pharmaceutical	pharmaceutical	NOUN
admet-2861	592	6	sciences	science	NOUN
admet-2861	592	7	1	1	NUM
admet-2861	592	8	(	(	PUNCT
admet-2861	592	9	1998	1998	NUM
admet-2861	592	10	)	)	PUNCT
admet-2861	592	11	90	90	NUM
admet-2861	592	12	-	-	SYM
admet-2861	592	13	91	91	NUM
admet-2861	592	14	.	.	PUNCT
admet-2861	593	1	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flipflop.htm	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flipflop.htm	PROPN
admet-2861	593	2	(	(	PUNCT
admet-2861	593	3	accessed	access	VERB
admet-2861	593	4	:	:	PUNCT
admet-2861	593	5	28.04.2025	28.04.2025	NUM
admet-2861	593	6	.	.	PUNCT
admet-2861	593	7	)	)	PUNCT
admet-2861	594	1	[	[	X
admet-2861	594	2	60	60	NUM
admet-2861	594	3	]	]	X
admet-2861	594	4	j.l	j.l	PROPN
admet-2861	594	5	.	.	PROPN
admet-2861	594	6	davis	davis	PROPN
admet-2861	594	7	,	,	PUNCT
admet-2861	594	8	chapter	chapter	NOUN
admet-2861	594	9	2	2	NUM
admet-2861	594	10	pharmacologic	pharmacologic	ADJ
admet-2861	594	11	principles	principle	NOUN
admet-2861	594	12	,	,	PUNCT
admet-2861	594	13	in	in	ADP
admet-2861	594	14	equine	equine	NOUN
admet-2861	594	15	internal	internal	ADJ
admet-2861	594	16	medicine	medicine	NOUN
admet-2861	594	17	(	(	PUNCT
admet-2861	594	18	fourth	fourth	PROPN
admet-2861	594	19	edition	edition	NOUN
admet-2861	594	20	)	)	PUNCT
admet-2861	594	21	,	,	PUNCT
admet-2861	594	22	s.m	s.m	PROPN
admet-2861	594	23	.	.	PROPN
admet-2861	594	24	reed	reed	PROPN
admet-2861	594	25	,	,	PUNCT
admet-2861	594	26	w.m	w.m	PROPN
admet-2861	594	27	.	.	PROPN
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admet-2861	594	29	,	,	PUNCT
admet-2861	594	30	d.c	d.c	PROPN
admet-2861	594	31	.	.	PROPN
admet-2861	594	32	sellon	sellon	PROPN
admet-2861	594	33	(	(	PUNCT
admet-2861	594	34	eds	ed	NOUN
admet-2861	594	35	.	.	PUNCT
admet-2861	594	36	)	)	PUNCT
admet-2861	594	37	,	,	PUNCT
admet-2861	594	38	w.b	w.b	PROPN
admet-2861	594	39	.	.	PROPN
admet-2861	594	40	saunders	saunder	NOUN
admet-2861	594	41	2018	2018	NUM
admet-2861	594	42	,	,	PUNCT
admet-2861	594	43	p.	p.	NOUN
admet-2861	594	44	79	79	NUM
admet-2861	594	45	-	-	SYM
admet-2861	594	46	137	137	NUM
admet-2861	594	47	978	978	NUM
admet-2861	594	48	-	-	SYM
admet-2861	594	49	0	0	NUM
admet-2861	594	50	-	-	PUNCT
admet-2861	594	51	323	323	NUM
admet-2861	594	52	-	-	PUNCT
admet-2861	594	53	44329	44329	NUM
admet-2861	594	54	-	-	SYM
admet-2861	594	55	6	6	NUM
admet-2861	594	56	.	.	PUNCT
admet-2861	594	57	https://doi.org/10.1016/b978-0-323-44329-6.00002-4	https://doi.org/10.1016/b978-0-323-44329-6.00002-4	NUM
admet-2861	595	1	[	[	X
admet-2861	595	2	61	61	NUM
admet-2861	595	3	]	]	X
admet-2861	595	4	g.	g.	NOUN
admet-2861	595	5	hochhaus	hochhaus	PROPN
admet-2861	595	6	,	,	PUNCT
admet-2861	595	7	h.	h.	PROPN
admet-2861	595	8	möllmann	möllmann	PROPN
admet-2861	595	9	,	,	PUNCT
admet-2861	595	10	h.	h.	PROPN
admet-2861	595	11	derendorf	derendorf	PROPN
admet-2861	595	12	,	,	PUNCT
admet-2861	595	13	r.j	r.j	PROPN
admet-2861	595	14	.	.	PROPN
admet-2861	595	15	gonzalez	gonzalez	PROPN
admet-2861	595	16	-	-	PUNCT
admet-2861	595	17	rothi	rothi	PROPN
admet-2861	595	18	.	.	PUNCT
admet-2861	596	1	pharmacokinetic	pharmacokinetic	ADJ
admet-2861	596	2	/	/	SYM
admet-2861	596	3	pharmacodynamic	pharmacodynamic	ADJ
admet-2861	596	4	aspects	aspect	NOUN
admet-2861	596	5	of	of	ADP
admet-2861	596	6	aerosol	aerosol	NOUN
admet-2861	596	7	therapy	therapy	NOUN
admet-2861	596	8	using	use	VERB
admet-2861	596	9	glucocorticoids	glucocorticoid	NOUN
admet-2861	596	10	as	as	ADP
admet-2861	596	11	a	a	DET
admet-2861	596	12	model	model	NOUN
admet-2861	596	13	.	.	PUNCT
admet-2861	597	1	journal	journal	PROPN
admet-2861	597	2	of	of	ADP
admet-2861	597	3	clinical	clinical	ADJ
admet-2861	597	4	pharmacology	pharmacology	NOUN
admet-2861	597	5	.	.	PUNCT
admet-2861	598	1	37	37	NUM
admet-2861	598	2	(	(	PUNCT
admet-2861	598	3	1997	1997	NUM
admet-2861	598	4	)	)	PUNCT
admet-2861	598	5	881	881	NUM
admet-2861	598	6	-	-	SYM
admet-2861	598	7	892	892	NUM
admet-2861	598	8	.	.	PUNCT
admet-2861	599	1	https://doi.org/10.1002/j.1552-4604.1997.tb04262.x	https://doi.org/10.1002/j.1552-4604.1997.tb04262.x	PROPN
admet-2861	599	2	.	.	PUNCT
admet-2861	600	1	[	[	X
admet-2861	600	2	62	62	NUM
admet-2861	600	3	]	]	X
admet-2861	600	4	j.e	j.e	PROPN
admet-2861	600	5	.	.	PROPN
admet-2861	600	6	hastedt	hastedt	PROPN
admet-2861	600	7	,	,	PUNCT
admet-2861	600	8	p.	p.	PROPN
admet-2861	600	9	bäckman	bäckman	NOUN
admet-2861	600	10	,	,	PUNCT
admet-2861	600	11	a.	a.	PROPN
admet-2861	600	12	cabal	cabal	PROPN
admet-2861	600	13	,	,	PUNCT
admet-2861	600	14	a.	a.	NOUN
admet-2861	600	15	clark	clark	PROPN
admet-2861	600	16	,	,	PUNCT
admet-2861	600	17	c.	c.	PROPN
admet-2861	600	18	ehrhardt	ehrhardt	PROPN
admet-2861	600	19	,	,	PUNCT
admet-2861	600	20	b.	b.	PROPN
admet-2861	600	21	forbes	forbes	PROPN
admet-2861	600	22	,	,	PUNCT
admet-2861	600	23	a.j	a.j	PROPN
admet-2861	600	24	.	.	PROPN
admet-2861	600	25	hickey	hickey	PROPN
admet-2861	600	26	,	,	PUNCT
admet-2861	600	27	g.	g.	PROPN
admet-2861	600	28	hochhaus	hochhaus	PROPN
admet-2861	600	29	,	,	PUNCT
admet-2861	600	30	w.	w.	PROPN
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admet-2861	600	39	,	,	PUNCT
admet-2861	600	40	d.	d.	PROPN
admet-2861	600	41	prime	prime	PROPN
admet-2861	600	42	,	,	PUNCT
admet-2861	600	43	y.j	y.j	PROPN
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admet-2861	600	46	,	,	PUNCT
admet-2861	600	47	s.	s.	PROPN
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admet-2861	600	50	u.	u.	PROPN
admet-2861	600	51	tehler	tehler	PROPN
admet-2861	600	52	,	,	PUNCT
admet-2861	600	53	j.	j.	PROPN
admet-2861	600	54	wylie	wylie	PROPN
admet-2861	600	55	.	.	PUNCT
admet-2861	601	1	ibcs	ibc	NOUN
admet-2861	601	2	:	:	PUNCT
admet-2861	601	3	3	3	X
admet-2861	601	4	.	.	X
admet-2861	601	5	a	a	DET
admet-2861	601	6	biopharmaceutics	biopharmaceutics	NOUN
admet-2861	601	7	classification	classification	NOUN
admet-2861	601	8	system	system	NOUN
admet-2861	601	9	for	for	ADP
admet-2861	601	10	orally	orally	ADV
admet-2861	601	11	inhaled	inhale	VERB
admet-2861	601	12	drug	drug	NOUN
admet-2861	601	13	products	product	NOUN
admet-2861	601	14	.	.	PUNCT
admet-2861	602	1	molecular	molecular	ADJ
admet-2861	602	2	pharmaceutics	pharmaceutic	NOUN
admet-2861	602	3	21	21	NUM
admet-2861	602	4	(	(	PUNCT
admet-2861	602	5	2024	2024	NUM
admet-2861	602	6	)	)	PUNCT
admet-2861	602	7	164	164	NUM
admet-2861	602	8	-	-	SYM
admet-2861	602	9	172	172	NUM
admet-2861	602	10	.	.	PUNCT
admet-2861	603	1	https://doi.org/10.1021/acs.molpharmaceut.3c00685	https://doi.org/10.1021/acs.molpharmaceut.3c00685	PROPN
admet-2861	603	2	©	©	PROPN
admet-2861	603	3	2025	2025	NUM
admet-2861	603	4	by	by	ADP
admet-2861	603	5	the	the	DET
admet-2861	603	6	authors	author	NOUN
admet-2861	603	7	;	;	PUNCT
admet-2861	603	8	licensee	licensee	PROPN
admet-2861	603	9	iapc	iapc	PROPN
admet-2861	603	10	,	,	PUNCT
admet-2861	603	11	zagreb	zagreb	PROPN
admet-2861	603	12	,	,	PUNCT
admet-2861	603	13	croatia	croatia	PROPN
admet-2861	603	14	.	.	PUNCT
admet-2861	604	1	this	this	DET
admet-2861	604	2	article	article	NOUN
admet-2861	604	3	is	be	AUX
admet-2861	604	4	an	an	DET
admet-2861	604	5	open	open	ADJ
admet-2861	604	6	-	-	PUNCT
admet-2861	604	7	access	access	NOUN
admet-2861	604	8	article	article	NOUN
admet-2861	604	9	distributed	distribute	VERB
admet-2861	604	10	under	under	ADP
admet-2861	604	11	the	the	DET
admet-2861	604	12	terms	term	NOUN
admet-2861	604	13	and	and	CCONJ
admet-2861	604	14	conditions	condition	NOUN
admet-2861	604	15	of	of	ADP
admet-2861	604	16	the	the	DET
admet-2861	604	17	creative	creative	ADJ
admet-2861	604	18	commons	common	NOUN
admet-2861	604	19	attribution	attribution	NOUN
admet-2861	604	20	license	license	NOUN
admet-2861	605	1	(	(	PUNCT
admet-2861	605	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2861	605	3	)	)	PUNCT
admet-2861	605	4	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flip-flop.htm	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flip-flop.htm	X
admet-2861	606	1	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flip-flop.htm	https://sites.ualberta.ca/~csps/jpps1(3)/h.boxenbaum/flip-flop.htm	NOUN
admet-2861	606	2	https://doi.org/10.1016/b978-0-323-44329-6.00002-4	https://doi.org/10.1016/b978-0-323-44329-6.00002-4	NUM
admet-2861	607	1	https://doi.org/10.1002/j.1552-4604.1997.tb04262.x	https://doi.org/10.1002/j.1552-4604.1997.tb04262.x	PROPN
admet-2861	607	2	https://doi.org/10.1021/acs.molpharmaceut.3c00685	https://doi.org/10.1021/acs.molpharmaceut.3c00685	ADJ
admet-2861	607	3	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN