id	sid	tid	token	lemma	pos
admet-2874	1	1	exploring	explore	VERB
admet-2874	1	2	hepatic	hepatic	ADJ
admet-2874	1	3	stellate	stellate	ADJ
admet-2874	1	4	cell	cell	NOUN
admet-2874	1	5	-	-	PUNCT
admet-2874	1	6	driven	drive	VERB
admet-2874	1	7	fibrosis	fibrosis	NOUN
admet-2874	1	8	:	:	PUNCT
admet-2874	1	9	doi	doi	NOUN
admet-2874	1	10	:	:	PUNCT
admet-2874	1	11	http://dx.doi.org/10.5599/admet.2874	http://dx.doi.org/10.5599/admet.2874	PUNCT
admet-2874	1	12	1	1	NUM
admet-2874	1	13	admet	admet	X
admet-2874	1	14	&	&	CCONJ
admet-2874	1	15	dmpk	dmpk	PROPN
admet-2874	1	16	13(4	13(4	NUM
admet-2874	1	17	)	)	PUNCT
admet-2874	1	18	(	(	PUNCT
admet-2874	1	19	2025	2025	NUM
admet-2874	1	20	)	)	PUNCT
admet-2874	1	21	2874	2874	NUM
admet-2874	1	22	;	;	PUNCT
admet-2874	1	23	doi	doi	NOUN
admet-2874	1	24	:	:	PUNCT
admet-2874	1	25	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	1	26	open	open	ADJ
admet-2874	1	27	access	access	NOUN
admet-2874	1	28	:	:	PUNCT
admet-2874	1	29	issn	issn	PROPN
admet-2874	1	30	:	:	PUNCT
admet-2874	1	31	1848	1848	NUM
admet-2874	1	32	-	-	SYM
admet-2874	1	33	7718	7718	NUM
admet-2874	1	34	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	NOUN
admet-2874	1	35	review	review	NOUN
admet-2874	1	36	exploring	explore	VERB
admet-2874	1	37	hepatic	hepatic	ADJ
admet-2874	1	38	stellate	stellate	ADJ
admet-2874	1	39	cell	cell	NOUN
admet-2874	1	40	-	-	PUNCT
admet-2874	1	41	driven	drive	VERB
admet-2874	1	42	fibrosis	fibrosis	NOUN
admet-2874	1	43	:	:	PUNCT
admet-2874	1	44	therapeutic	therapeutic	ADJ
admet-2874	1	45	advances	advance	NOUN
admet-2874	1	46	and	and	CCONJ
admet-2874	1	47	future	future	ADJ
admet-2874	1	48	perspectives	perspective	NOUN
admet-2874	1	49	alka	alka	PROPN
admet-2874	1	50	singh1	singh1	PROPN
admet-2874	1	51	,	,	PUNCT
admet-2874	1	52	ansab	ansab	ADV
admet-2874	1	53	akhtar2	akhtar2	PROPN
admet-2874	1	54	and	and	CCONJ
admet-2874	1	55	prashant	prashant	PROPN
admet-2874	1	56	shukla1	shukla1	PROPN
admet-2874	1	57	*	*	PROPN
admet-2874	1	58	1department	1department	NUM
admet-2874	1	59	of	of	ADP
admet-2874	1	60	pharmaceutical	pharmaceutical	ADJ
admet-2874	1	61	sciences	science	NOUN
admet-2874	1	62	,	,	PUNCT
admet-2874	1	63	school	school	NOUN
admet-2874	1	64	of	of	ADP
admet-2874	1	65	health	health	NOUN
admet-2874	1	66	sciences	sciences	PROPN
admet-2874	1	67	and	and	CCONJ
admet-2874	1	68	technology	technology	NOUN
admet-2874	1	69	,	,	PUNCT
admet-2874	1	70	upes	upe	NOUN
admet-2874	1	71	,	,	PUNCT
admet-2874	1	72	dehradun	dehradun	PROPN
admet-2874	1	73	,	,	PUNCT
admet-2874	1	74	india	india	PROPN
admet-2874	1	75	2louisiana	2louisiana	PROPN
admet-2874	1	76	state	state	PROPN
admet-2874	1	77	university	university	PROPN
admet-2874	1	78	,	,	PUNCT
admet-2874	1	79	health	health	PROPN
admet-2874	1	80	sciences	sciences	PROPN
admet-2874	1	81	center	center	PROPN
admet-2874	1	82	,	,	PUNCT
admet-2874	1	83	new	new	PROPN
admet-2874	1	84	orleans	orleans	PROPN
admet-2874	1	85	,	,	PUNCT
admet-2874	1	86	united	united	PROPN
admet-2874	1	87	states	states	PROPN
admet-2874	1	88	*	*	PUNCT
admet-2874	1	89	corresponding	correspond	VERB
admet-2874	1	90	authors	author	NOUN
admet-2874	1	91	:	:	PUNCT
admet-2874	1	92	e	e	X
admet-2874	1	93	-	-	NOUN
admet-2874	1	94	mail	mail	NOUN
admet-2874	1	95	:	:	PUNCT
admet-2874	1	96	prashukla@outlook.com	prashukla@outlook.com	X
admet-2874	1	97	;	;	PUNCT
admet-2874	1	98	tel	tel	PROPN
admet-2874	1	99	.	.	PUNCT
admet-2874	2	1	:	:	PUNCT
admet-2874	2	2	+91	+91	PROPN
admet-2874	2	3	-	-	PUNCT
admet-2874	2	4	8801665202	8801665202	NUM
admet-2874	2	5	received	receive	VERB
admet-2874	2	6	:	:	PUNCT
admet-2874	2	7	june	june	PROPN
admet-2874	2	8	4	4	NUM
admet-2874	2	9	,	,	PUNCT
admet-2874	2	10	2025	2025	NUM
admet-2874	2	11	;	;	PUNCT
admet-2874	2	12	revised	revise	VERB
admet-2874	2	13	:	:	PUNCT
admet-2874	2	14	july	july	PROPN
admet-2874	2	15	31	31	NUM
admet-2874	2	16	,	,	PUNCT
admet-2874	2	17	2025	2025	NUM
admet-2874	2	18	;	;	PUNCT
admet-2874	2	19	published	publish	VERB
admet-2874	2	20	:	:	PUNCT
admet-2874	2	21	august	august	PROPN
admet-2874	2	22	4	4	NUM
admet-2874	2	23	,	,	PUNCT
admet-2874	2	24	2025	2025	NUM
admet-2874	2	25	abstract	abstract	ADJ
admet-2874	2	26	background	background	NOUN
admet-2874	2	27	and	and	CCONJ
admet-2874	2	28	purpose	purpose	NOUN
admet-2874	2	29	:	:	PUNCT
admet-2874	2	30	liver	liver	NOUN
admet-2874	2	31	fibrosis	fibrosis	NOUN
admet-2874	2	32	,	,	PUNCT
admet-2874	2	33	a	a	DET
admet-2874	2	34	progressive	progressive	ADJ
admet-2874	2	35	liver	liver	NOUN
admet-2874	2	36	disease	disease	NOUN
admet-2874	2	37	arising	arise	VERB
admet-2874	2	38	from	from	ADP
admet-2874	2	39	viral	viral	ADJ
admet-2874	2	40	or	or	CCONJ
admet-2874	2	41	metabolic	metabolic	NOUN
admet-2874	2	42	causes	cause	NOUN
admet-2874	2	43	,	,	PUNCT
admet-2874	2	44	poses	pose	VERB
admet-2874	2	45	a	a	DET
admet-2874	2	46	major	major	ADJ
admet-2874	2	47	global	global	ADJ
admet-2874	2	48	health	health	NOUN
admet-2874	2	49	challenge	challenge	NOUN
admet-2874	2	50	due	due	ADP
admet-2874	2	51	to	to	ADP
admet-2874	2	52	its	its	PRON
admet-2874	2	53	potential	potential	ADJ
admet-2874	2	54	progression	progression	NOUN
admet-2874	2	55	to	to	ADP
admet-2874	2	56	cirrhosis	cirrhosis	NOUN
admet-2874	2	57	and	and	CCONJ
admet-2874	2	58	hepatocellular	hepatocellular	ADJ
admet-2874	2	59	carcinoma	carcinoma	NOUN
admet-2874	2	60	.	.	PUNCT
admet-2874	3	1	due	due	ADP
admet-2874	3	2	to	to	ADP
admet-2874	3	3	the	the	DET
admet-2874	3	4	complex	complex	ADJ
admet-2874	3	5	aetiology	aetiology	NOUN
admet-2874	3	6	and	and	CCONJ
admet-2874	3	7	epidemiology	epidemiology	NOUN
admet-2874	3	8	of	of	ADP
admet-2874	3	9	liver	liver	NOUN
admet-2874	3	10	fibrosis	fibrosis	NOUN
admet-2874	3	11	,	,	PUNCT
admet-2874	3	12	most	most	ADJ
admet-2874	3	13	therapies	therapy	NOUN
admet-2874	3	14	fail	fail	VERB
admet-2874	3	15	in	in	ADP
admet-2874	3	16	the	the	DET
admet-2874	3	17	clinic	clinic	NOUN
admet-2874	3	18	,	,	PUNCT
admet-2874	3	19	and	and	CCONJ
admet-2874	3	20	very	very	ADV
admet-2874	3	21	few	few	ADJ
admet-2874	3	22	drugs	drug	NOUN
admet-2874	3	23	have	have	AUX
admet-2874	3	24	been	be	AUX
admet-2874	3	25	approved	approve	VERB
admet-2874	3	26	by	by	ADP
admet-2874	3	27	the	the	DET
admet-2874	3	28	us	us	PROPN
admet-2874	4	1	fda	fda	PROPN
admet-2874	4	2	.	.	PROPN
admet-2874	4	3	approach	approach	PROPN
admet-2874	4	4	:	:	PUNCT
admet-2874	4	5	this	this	DET
admet-2874	4	6	review	review	NOUN
admet-2874	4	7	highlights	highlight	VERB
admet-2874	4	8	the	the	DET
admet-2874	4	9	pathophysiological	pathophysiological	ADJ
admet-2874	4	10	features	feature	NOUN
admet-2874	4	11	of	of	ADP
admet-2874	4	12	liver	liver	NOUN
admet-2874	4	13	fibrosis	fibrosis	NOUN
admet-2874	4	14	,	,	PUNCT
admet-2874	4	15	with	with	ADP
admet-2874	4	16	a	a	DET
admet-2874	4	17	focus	focus	NOUN
admet-2874	4	18	on	on	ADP
admet-2874	4	19	novel	novel	ADJ
admet-2874	4	20	targets	target	NOUN
admet-2874	4	21	in	in	ADP
admet-2874	4	22	hepatic	hepatic	ADJ
admet-2874	4	23	stellate	stellate	ADJ
admet-2874	4	24	cells	cell	NOUN
admet-2874	4	25	(	(	PUNCT
admet-2874	4	26	hscs	hsc	NOUN
admet-2874	4	27	)	)	PUNCT
admet-2874	4	28	,	,	PUNCT
admet-2874	4	29	key	key	ADJ
admet-2874	4	30	players	player	NOUN
admet-2874	4	31	in	in	ADP
admet-2874	4	32	the	the	DET
admet-2874	4	33	fibrogenesis	fibrogenesis	ADJ
admet-2874	4	34	process	process	NOUN
admet-2874	4	35	,	,	PUNCT
admet-2874	4	36	to	to	PART
admet-2874	4	37	develop	develop	VERB
admet-2874	4	38	successful	successful	ADJ
admet-2874	4	39	therapeutic	therapeutic	ADJ
admet-2874	4	40	approaches	approach	NOUN
admet-2874	4	41	using	use	VERB
admet-2874	4	42	both	both	DET
admet-2874	4	43	pharmacological	pharmacological	ADJ
admet-2874	4	44	agents	agent	NOUN
admet-2874	4	45	and	and	CCONJ
admet-2874	4	46	active	active	ADJ
admet-2874	4	47	targeting	targeting	NOUN
admet-2874	4	48	strategies	strategy	NOUN
admet-2874	4	49	.	.	PUNCT
admet-2874	5	1	the	the	DET
admet-2874	5	2	review	review	NOUN
admet-2874	5	3	also	also	ADV
admet-2874	5	4	examines	examine	VERB
admet-2874	5	5	current	current	ADJ
admet-2874	5	6	therapeutic	therapeutic	ADJ
admet-2874	5	7	strategies	strategy	NOUN
admet-2874	5	8	targeting	target	VERB
admet-2874	5	9	liver	liver	NOUN
admet-2874	5	10	fibrosis	fibrosis	NOUN
admet-2874	5	11	,	,	PUNCT
admet-2874	5	12	both	both	CCONJ
admet-2874	5	13	in	in	ADP
admet-2874	5	14	preclinical	preclinical	ADJ
admet-2874	5	15	lab	lab	NOUN
admet-2874	5	16	setups	setup	NOUN
admet-2874	5	17	and	and	CCONJ
admet-2874	5	18	clinical	clinical	ADJ
admet-2874	5	19	trials	trial	NOUN
admet-2874	5	20	.	.	PUNCT
admet-2874	6	1	furthermore	furthermore	ADV
admet-2874	6	2	,	,	PUNCT
admet-2874	6	3	various	various	ADJ
admet-2874	6	4	receptors	receptor	NOUN
admet-2874	6	5	involved	involve	VERB
admet-2874	6	6	in	in	ADP
admet-2874	6	7	hsc	hsc	NOUN
admet-2874	6	8	-	-	PUNCT
admet-2874	6	9	mediated	mediate	VERB
admet-2874	6	10	liver	liver	NOUN
admet-2874	6	11	fibrosis	fibrosis	NOUN
admet-2874	6	12	and	and	CCONJ
admet-2874	6	13	active	active	ADJ
admet-2874	6	14	drug	drug	NOUN
admet-2874	6	15	delivery	delivery	NOUN
admet-2874	6	16	targeting	targeting	NOUN
admet-2874	6	17	strategies	strategy	NOUN
admet-2874	6	18	are	be	AUX
admet-2874	6	19	reviewed	review	VERB
admet-2874	6	20	to	to	PART
admet-2874	6	21	enhance	enhance	VERB
admet-2874	6	22	therapeutic	therapeutic	ADJ
admet-2874	6	23	outcomes	outcome	NOUN
admet-2874	6	24	.	.	PUNCT
admet-2874	7	1	this	this	DET
admet-2874	7	2	article	article	NOUN
admet-2874	7	3	also	also	ADV
admet-2874	7	4	integrates	integrate	VERB
admet-2874	7	5	existing	exist	VERB
admet-2874	7	6	knowledge	knowledge	NOUN
admet-2874	7	7	to	to	PART
admet-2874	7	8	identify	identify	VERB
admet-2874	7	9	research	research	NOUN
admet-2874	7	10	gaps	gap	NOUN
admet-2874	7	11	and	and	CCONJ
admet-2874	7	12	guide	guide	VERB
admet-2874	7	13	future	future	ADJ
admet-2874	7	14	investigations	investigation	NOUN
admet-2874	7	15	and	and	CCONJ
admet-2874	7	16	clinical	clinical	ADJ
admet-2874	7	17	translation	translation	NOUN
admet-2874	7	18	in	in	ADP
admet-2874	7	19	liver	liver	NOUN
admet-2874	7	20	fibrosis	fibrosis	NOUN
admet-2874	7	21	treatment	treatment	NOUN
admet-2874	7	22	.	.	PUNCT
admet-2874	8	1	in	in	ADP
admet-2874	8	2	addition	addition	NOUN
admet-2874	8	3	,	,	PUNCT
admet-2874	8	4	novel	novel	ADJ
admet-2874	8	5	pathways	pathway	NOUN
admet-2874	8	6	pertaining	pertain	VERB
admet-2874	8	7	to	to	ADP
admet-2874	8	8	liver	liver	NOUN
admet-2874	8	9	fibrosis	fibrosis	NOUN
admet-2874	8	10	,	,	PUNCT
admet-2874	8	11	such	such	ADJ
admet-2874	8	12	as	as	ADP
admet-2874	8	13	the	the	DET
admet-2874	8	14	rspo3	rspo3	NOUN
admet-2874	8	15	-	-	PUNCT
admet-2874	8	16	lgr4/5	lgr4/5	NOUN
admet-2874	8	17	-	-	PUNCT
admet-2874	8	18	β	β	ADJ
admet-2874	8	19	-	-	ADJ
admet-2874	8	20	catenin	catenin	ADJ
admet-2874	8	21	cascade	cascade	NOUN
admet-2874	8	22	,	,	PUNCT
admet-2874	8	23	the	the	DET
admet-2874	8	24	cd47	cd47	PROPN
admet-2874	8	25	/	/	SYM
admet-2874	8	26	yap	yap	NOUN
admet-2874	8	27	/	/	SYM
admet-2874	8	28	tead4	tead4	NOUN
admet-2874	8	29	signalling	signal	VERB
admet-2874	8	30	axis	axis	NOUN
admet-2874	8	31	,	,	PUNCT
admet-2874	8	32	and	and	CCONJ
admet-2874	8	33	hab18g	hab18g	PROPN
admet-2874	8	34	/	/	SYM
admet-2874	8	35	cd147	cd147	PROPN
admet-2874	8	36	,	,	PUNCT
admet-2874	8	37	are	be	AUX
admet-2874	8	38	briefly	briefly	ADV
admet-2874	8	39	elaborated	elaborate	VERB
admet-2874	8	40	in	in	ADP
admet-2874	8	41	the	the	DET
admet-2874	8	42	context	context	NOUN
admet-2874	8	43	of	of	ADP
admet-2874	8	44	therapeutic	therapeutic	ADJ
admet-2874	8	45	approaches	approach	NOUN
admet-2874	8	46	for	for	ADP
admet-2874	8	47	arresting	arrest	VERB
admet-2874	8	48	hsc	hsc	NOUN
admet-2874	8	49	activation	activation	NOUN
admet-2874	8	50	.	.	PUNCT
admet-2874	9	1	single	single	ADJ
admet-2874	9	2	-	-	PUNCT
admet-2874	9	3	cell	cell	NOUN
admet-2874	9	4	rna	rna	NOUN
admet-2874	9	5	sequencing	sequencing	NOUN
admet-2874	9	6	of	of	ADP
admet-2874	9	7	hscs	hsc	NOUN
admet-2874	9	8	is	be	AUX
admet-2874	9	9	presented	present	VERB
admet-2874	9	10	to	to	PART
admet-2874	9	11	provide	provide	VERB
admet-2874	9	12	a	a	DET
admet-2874	9	13	clearer	clear	ADJ
admet-2874	9	14	picture	picture	NOUN
admet-2874	9	15	of	of	ADP
admet-2874	9	16	liver	liver	NOUN
admet-2874	9	17	fibrosis	fibrosis	NOUN
admet-2874	9	18	.	.	PUNCT
admet-2874	10	1	conclusion	conclusion	NOUN
admet-2874	10	2	:	:	PUNCT
admet-2874	10	3	the	the	DET
admet-2874	10	4	review	review	NOUN
admet-2874	10	5	highlights	highlight	VERB
admet-2874	10	6	critical	critical	ADJ
admet-2874	10	7	research	research	NOUN
admet-2874	10	8	gaps	gap	NOUN
admet-2874	10	9	in	in	ADP
admet-2874	10	10	liver	liver	NOUN
admet-2874	10	11	fibrosis	fibrosis	NOUN
admet-2874	10	12	therapy	therapy	NOUN
admet-2874	10	13	and	and	CCONJ
admet-2874	10	14	promising	promise	VERB
admet-2874	10	15	active	active	ADJ
admet-2874	10	16	targeting	targeting	NOUN
admet-2874	10	17	strategies	strategy	NOUN
admet-2874	10	18	and	and	CCONJ
admet-2874	10	19	pharmacological	pharmacological	ADJ
admet-2874	10	20	interventions	intervention	NOUN
admet-2874	10	21	to	to	PART
admet-2874	10	22	improve	improve	VERB
admet-2874	10	23	therapeutic	therapeutic	ADJ
admet-2874	10	24	outcomes	outcome	NOUN
admet-2874	10	25	.	.	PUNCT
admet-2874	11	1	overall	overall	ADV
admet-2874	11	2	,	,	PUNCT
admet-2874	11	3	this	this	DET
admet-2874	11	4	review	review	NOUN
admet-2874	11	5	provides	provide	VERB
admet-2874	11	6	a	a	DET
admet-2874	11	7	robust	robust	ADJ
admet-2874	11	8	foundation	foundation	NOUN
admet-2874	11	9	for	for	ADP
admet-2874	11	10	scientists	scientist	NOUN
admet-2874	11	11	and	and	CCONJ
admet-2874	11	12	clinicians	clinician	NOUN
admet-2874	11	13	to	to	PART
admet-2874	11	14	advance	advance	VERB
admet-2874	11	15	active	active	ADJ
admet-2874	11	16	targeting	targeting	NOUN
admet-2874	11	17	of	of	ADP
admet-2874	11	18	the	the	DET
admet-2874	11	19	disease	disease	NOUN
admet-2874	11	20	pathology	pathology	NOUN
admet-2874	11	21	and	and	CCONJ
admet-2874	11	22	to	to	PART
admet-2874	11	23	develop	develop	VERB
admet-2874	11	24	new	new	ADJ
admet-2874	11	25	pharmaceutical	pharmaceutical	NOUN
admet-2874	11	26	formulations	formulation	NOUN
admet-2874	11	27	that	that	PRON
admet-2874	11	28	are	be	AUX
admet-2874	11	29	pharmacologically	pharmacologically	ADV
admet-2874	11	30	safer	safe	ADJ
admet-2874	11	31	and	and	CCONJ
admet-2874	11	32	more	more	ADV
admet-2874	11	33	efficacious	efficacious	ADJ
admet-2874	11	34	.	.	PUNCT
admet-2874	12	1	©	©	NOUN
admet-2874	12	2	2025	2025	NUM
admet-2874	12	3	by	by	ADP
admet-2874	12	4	the	the	DET
admet-2874	12	5	authors	author	NOUN
admet-2874	12	6	.	.	PUNCT
admet-2874	13	1	this	this	DET
admet-2874	13	2	article	article	NOUN
admet-2874	13	3	is	be	AUX
admet-2874	13	4	an	an	DET
admet-2874	13	5	open	open	ADJ
admet-2874	13	6	-	-	PUNCT
admet-2874	13	7	access	access	NOUN
admet-2874	13	8	article	article	NOUN
admet-2874	13	9	distributed	distribute	VERB
admet-2874	13	10	under	under	ADP
admet-2874	13	11	the	the	DET
admet-2874	13	12	terms	term	NOUN
admet-2874	13	13	and	and	CCONJ
admet-2874	13	14	conditions	condition	NOUN
admet-2874	13	15	of	of	ADP
admet-2874	13	16	the	the	DET
admet-2874	13	17	creative	creative	ADJ
admet-2874	13	18	commons	common	NOUN
admet-2874	13	19	attribution	attribution	NOUN
admet-2874	13	20	license	license	NOUN
admet-2874	13	21	(	(	PUNCT
admet-2874	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2874	13	23	)	)	PUNCT
admet-2874	13	24	.	.	PUNCT
admet-2874	14	1	keywords	keyword	VERB
admet-2874	14	2	retinoid	retinoid	NOUN
admet-2874	14	3	receptors	receptor	NOUN
admet-2874	14	4	;	;	PUNCT
admet-2874	14	5	non	non	ADJ
admet-2874	14	6	-	-	ADJ
admet-2874	14	7	alcoholic	alcoholic	ADJ
admet-2874	14	8	fatty	fatty	NOUN
admet-2874	14	9	liver	liver	NOUN
admet-2874	14	10	disease	disease	NOUN
admet-2874	14	11	;	;	PUNCT
admet-2874	14	12	resmetirom	resmetirom	ADJ
admet-2874	14	13	;	;	PUNCT
admet-2874	14	14	liposomes	liposome	NOUN
admet-2874	14	15	;	;	PUNCT
admet-2874	14	16	active	active	ADJ
admet-2874	14	17	targeting	targeting	NOUN
admet-2874	14	18	;	;	PUNCT
admet-2874	14	19	clinical	clinical	ADJ
admet-2874	14	20	trials	trial	NOUN
admet-2874	14	21	1	1	NUM
admet-2874	14	22	.	.	PUNCT
admet-2874	15	1	introduction	introduction	NOUN
admet-2874	15	2	one	one	NUM
admet-2874	15	3	out	out	ADP
admet-2874	15	4	of	of	ADP
admet-2874	15	5	every	every	DET
admet-2874	15	6	twenty	twenty	NUM
admet-2874	15	7	-	-	PUNCT
admet-2874	15	8	five	five	NUM
admet-2874	15	9	deaths	death	NOUN
admet-2874	15	10	globally	globally	ADV
admet-2874	15	11	is	be	AUX
admet-2874	15	12	caused	cause	VERB
admet-2874	15	13	by	by	ADP
admet-2874	15	14	liver	liver	NOUN
admet-2874	15	15	fibrosis	fibrosis	NOUN
admet-2874	15	16	,	,	PUNCT
admet-2874	15	17	thus	thus	ADV
admet-2874	15	18	causing	cause	VERB
admet-2874	15	19	a	a	DET
admet-2874	15	20	huge	huge	ADJ
admet-2874	15	21	health	health	NOUN
admet-2874	15	22	burden	burden	NOUN
admet-2874	15	23	worldwide	worldwide	ADV
admet-2874	15	24	.	.	PUNCT
admet-2874	16	1	globally	globally	ADV
admet-2874	16	2	,	,	PUNCT
admet-2874	16	3	the	the	DET
admet-2874	16	4	prevalence	prevalence	NOUN
admet-2874	16	5	of	of	ADP
admet-2874	16	6	advanced	advanced	ADJ
admet-2874	16	7	liver	liver	NOUN
admet-2874	16	8	fibrosis	fibrosis	NOUN
admet-2874	16	9	in	in	ADP
admet-2874	16	10	the	the	DET
admet-2874	16	11	general	general	ADJ
admet-2874	16	12	population	population	NOUN
admet-2874	16	13	was	be	AUX
admet-2874	16	14	estimated	estimate	VERB
admet-2874	16	15	to	to	PART
admet-2874	16	16	be	be	AUX
admet-2874	16	17	3.3	3.3	NUM
admet-2874	16	18	%	%	NOUN
admet-2874	16	19	(	(	PUNCT
admet-2874	16	20	range	range	VERB
admet-2874	16	21	2.4	2.4	NUM
admet-2874	16	22	to	to	PART
admet-2874	16	23	4.2	4.2	NUM
admet-2874	16	24	%	%	NOUN
admet-2874	16	25	with	with	ADP
admet-2874	16	26	95	95	NUM
admet-2874	16	27	%	%	NOUN
admet-2874	16	28	ci	ci	NOUN
admet-2874	16	29	)	)	PUNCT
admet-2874	17	1	[	[	X
admet-2874	17	2	1	1	NUM
admet-2874	17	3	]	]	PUNCT
admet-2874	17	4	.	.	PUNCT
admet-2874	18	1	there	there	PRON
admet-2874	18	2	are	be	VERB
admet-2874	18	3	various	various	ADJ
admet-2874	18	4	aetiologies	aetiology	NOUN
admet-2874	18	5	involved	involve	VERB
admet-2874	18	6	in	in	ADP
admet-2874	18	7	inducing	induce	VERB
admet-2874	18	8	liver	liver	NOUN
admet-2874	18	9	injuries	injury	NOUN
admet-2874	18	10	such	such	ADJ
admet-2874	18	11	as	as	ADP
admet-2874	18	12	alcohol	alcohol	NOUN
admet-2874	18	13	,	,	PUNCT
admet-2874	18	14	cholestasis	cholestasis	NOUN
admet-2874	18	15	,	,	PUNCT
admet-2874	18	16	non	non	ADJ
admet-2874	18	17	-	-	ADJ
admet-2874	18	18	alcoholic	alcoholic	ADJ
admet-2874	18	19	fatty	fatty	NOUN
admet-2874	18	20	liver	liver	NOUN
admet-2874	18	21	disease	disease	NOUN
admet-2874	18	22	,	,	PUNCT
admet-2874	18	23	autoimmune	autoimmune	PROPN
admet-2874	18	24	steatohepatitis	steatohepatitis	PROPN
admet-2874	18	25	,	,	PUNCT
admet-2874	18	26	and	and	CCONJ
admet-2874	18	27	drug	drug	NOUN
admet-2874	18	28	-	-	PUNCT
admet-2874	18	29	induced	induce	VERB
admet-2874	18	30	liver	liver	NOUN
admet-2874	18	31	injury	injury	NOUN
admet-2874	18	32	reactions	reaction	NOUN
admet-2874	18	33	[	[	X
admet-2874	18	34	2	2	NUM
admet-2874	18	35	]	]	PUNCT
admet-2874	18	36	,	,	PUNCT
admet-2874	18	37	primary	primary	ADJ
admet-2874	18	38	biliary	biliary	NOUN
admet-2874	18	39	cholangitis	cholangitis	NOUN
admet-2874	18	40	(	(	PUNCT
admet-2874	18	41	pbc	pbc	PROPN
admet-2874	18	42	)	)	PUNCT
admet-2874	18	43	,	,	PUNCT
admet-2874	18	44	primary	primary	ADJ
admet-2874	18	45	sclerosing	sclerose	VERB
admet-2874	18	46	cholangitis	cholangitis	NOUN
admet-2874	18	47	(	(	PUNCT
admet-2874	18	48	psc	psc	PROPN
admet-2874	18	49	)	)	PUNCT
admet-2874	18	50	;	;	PUNCT
admet-2874	18	51	viral	viral	ADJ
admet-2874	18	52	hepatitis	hepatitis	NOUN
admet-2874	18	53	(	(	PUNCT
admet-2874	18	54	hepatitis	hepatitis	NOUN
admet-2874	18	55	b	b	PROPN
admet-2874	18	56	and	and	CCONJ
admet-2874	18	57	hepatitis	hepatitis	PROPN
admet-2874	18	58	c	c	PROPN
admet-2874	18	59	)	)	PUNCT
admet-2874	18	60	;	;	PUNCT
admet-2874	18	61	autoimmune	autoimmune	ADJ
admet-2874	18	62	hepatitis	hepatitis	PROPN
admet-2874	18	63	(	(	PUNCT
admet-2874	18	64	aih	aih	PROPN
admet-2874	18	65	)	)	PUNCT
admet-2874	19	1	[	[	X
admet-2874	19	2	3	3	NUM
admet-2874	19	3	]	]	PUNCT
admet-2874	19	4	.	.	PUNCT
admet-2874	20	1	these	these	DET
admet-2874	20	2	factors	factor	NOUN
admet-2874	20	3	lead	lead	VERB
admet-2874	20	4	to	to	ADP
admet-2874	20	5	a	a	DET
admet-2874	20	6	dynamic	dynamic	ADJ
admet-2874	20	7	process	process	NOUN
admet-2874	20	8	of	of	ADP
admet-2874	20	9	cells	cell	NOUN
admet-2874	20	10	and	and	CCONJ
admet-2874	20	11	tissues	tissue	NOUN
admet-2874	20	12	,	,	PUNCT
admet-2874	20	13	responsible	responsible	ADJ
admet-2874	20	14	for	for	ADP
admet-2874	20	15	extracellular	extracellular	ADJ
admet-2874	20	16	matrix	matrix	NOUN
admet-2874	20	17	(	(	PUNCT
admet-2874	20	18	ecm	ecm	NOUN
admet-2874	20	19	)	)	PUNCT
admet-2874	20	20	deposition	deposition	NOUN
admet-2874	20	21	via	via	ADP
admet-2874	20	22	the	the	DET
admet-2874	20	23	activation	activation	NOUN
admet-2874	20	24	of	of	ADP
admet-2874	20	25	hepatic	hepatic	ADJ
admet-2874	20	26	stellate	stellate	ADJ
admet-2874	20	27	and	and	CCONJ
admet-2874	20	28	myofibroblast	myofibroblast	NOUN
admet-2874	20	29	cells	cell	NOUN
admet-2874	20	30	.	.	PUNCT
admet-2874	21	1	http://dx.doi.org/10.5599/admet.2874	http://dx.doi.org/10.5599/admet.2874	X
admet-2874	22	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	22	2	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-2874	22	3	mailto:prashukla@outlook.com	mailto:prashukla@outlook.com	X
admet-2874	22	4	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2874	22	5	a.	a.	PROPN
admet-2874	22	6	singh	singh	PROPN
admet-2874	22	7	et	et	PROPN
admet-2874	22	8	al	al	PROPN
admet-2874	22	9	.	.	PROPN
admet-2874	22	10	admet	admet	PROPN
admet-2874	22	11	&	&	CCONJ
admet-2874	22	12	dmpk	dmpk	PROPN
admet-2874	22	13	13(4	13(4	NUM
admet-2874	22	14	)	)	PUNCT
admet-2874	22	15	(	(	PUNCT
admet-2874	22	16	2025	2025	NUM
admet-2874	22	17	)	)	PUNCT
admet-2874	22	18	2874	2874	NUM
admet-2874	22	19	2	2	NUM
admet-2874	22	20	liver	liver	NOUN
admet-2874	22	21	fibrosis	fibrosis	NOUN
admet-2874	22	22	develops	develop	VERB
admet-2874	22	23	as	as	ADP
admet-2874	22	24	a	a	DET
admet-2874	22	25	result	result	NOUN
admet-2874	22	26	of	of	ADP
admet-2874	22	27	the	the	DET
admet-2874	22	28	interplay	interplay	NOUN
admet-2874	22	29	of	of	ADP
admet-2874	22	30	various	various	ADJ
admet-2874	22	31	cell	cell	NOUN
admet-2874	22	32	types	type	NOUN
admet-2874	22	33	,	,	PUNCT
admet-2874	22	34	i.e.	i.e.	X
admet-2874	22	35	hepatocytes	hepatocyte	NOUN
admet-2874	22	36	,	,	PUNCT
admet-2874	22	37	cholangiocytes	cholangiocyte	NOUN
admet-2874	22	38	,	,	PUNCT
admet-2874	22	39	natural	natural	ADJ
admet-2874	22	40	killer	killer	NOUN
admet-2874	22	41	cells	cell	NOUN
admet-2874	22	42	(	(	PUNCT
admet-2874	22	43	nk	nk	PROPN
admet-2874	22	44	cells	cell	NOUN
admet-2874	22	45	)	)	PUNCT
admet-2874	22	46	,	,	PUNCT
admet-2874	22	47	t	t	PROPN
admet-2874	22	48	helper	helper	NOUN
admet-2874	22	49	cells	cell	NOUN
admet-2874	22	50	,	,	PUNCT
admet-2874	22	51	kupffer	kupffer	NOUN
admet-2874	22	52	cells	cell	NOUN
admet-2874	22	53	,	,	PUNCT
admet-2874	22	54	liver	liver	NOUN
admet-2874	22	55	sinusoidal	sinusoidal	NOUN
admet-2874	22	56	and	and	CCONJ
admet-2874	22	57	epithelial	epithelial	ADJ
admet-2874	22	58	cells	cell	NOUN
admet-2874	22	59	,	,	PUNCT
admet-2874	22	60	along	along	ADP
admet-2874	22	61	with	with	ADP
admet-2874	22	62	hsc	hsc	PROPN
admet-2874	22	63	.	.	PUNCT
admet-2874	23	1	although	although	SCONJ
admet-2874	23	2	the	the	DET
admet-2874	23	3	main	main	ADJ
admet-2874	23	4	functions	function	NOUN
admet-2874	23	5	of	of	ADP
admet-2874	23	6	hepatocytes	hepatocyte	NOUN
admet-2874	23	7	include	include	VERB
admet-2874	23	8	the	the	DET
admet-2874	23	9	clearance	clearance	NOUN
admet-2874	23	10	of	of	ADP
admet-2874	23	11	hepatitis	hepatitis	NOUN
admet-2874	23	12	viruses	virus	NOUN
admet-2874	23	13	,	,	PUNCT
admet-2874	23	14	toxic	toxic	ADJ
admet-2874	23	15	metabolites	metabolite	NOUN
admet-2874	23	16	,	,	PUNCT
admet-2874	23	17	and	and	CCONJ
admet-2874	23	18	xenobiotic	xenobiotic	ADJ
admet-2874	23	19	compounds	compound	NOUN
admet-2874	23	20	,	,	PUNCT
admet-2874	23	21	as	as	ADV
admet-2874	23	22	well	well	ADV
admet-2874	23	23	as	as	ADP
admet-2874	23	24	the	the	DET
admet-2874	23	25	secretion	secretion	NOUN
admet-2874	23	26	of	of	ADP
admet-2874	23	27	lipids	lipid	NOUN
admet-2874	23	28	and	and	CCONJ
admet-2874	23	29	proteins	protein	NOUN
admet-2874	23	30	,	,	PUNCT
admet-2874	23	31	apoptotic	apoptotic	ADJ
admet-2874	23	32	hepatocytes	hepatocyte	NOUN
admet-2874	23	33	in	in	ADP
admet-2874	23	34	an	an	DET
admet-2874	23	35	injured	injure	VERB
admet-2874	23	36	liver	liver	NOUN
admet-2874	23	37	succumb	succumb	ADJ
admet-2874	23	38	,	,	PUNCT
admet-2874	23	39	leading	lead	VERB
admet-2874	23	40	to	to	ADP
admet-2874	23	41	the	the	DET
admet-2874	23	42	activation	activation	NOUN
admet-2874	23	43	of	of	ADP
admet-2874	23	44	myofibroblasts	myofibroblast	NOUN
admet-2874	23	45	.	.	PUNCT
admet-2874	24	1	in	in	ADP
admet-2874	24	2	addition	addition	NOUN
admet-2874	24	3	,	,	PUNCT
admet-2874	24	4	inflammatory	inflammatory	ADJ
admet-2874	24	5	mediators	mediator	NOUN
admet-2874	24	6	,	,	PUNCT
admet-2874	24	7	including	include	VERB
admet-2874	24	8	tgf	tgf	PROPN
admet-2874	24	9	-	-	PUNCT
admet-2874	24	10	β1	β1	PROPN
admet-2874	24	11	,	,	PUNCT
admet-2874	24	12	tnf	tnf	PROPN
admet-2874	24	13	-	-	PUNCT
admet-2874	24	14	α	α	PROPN
admet-2874	24	15	,	,	PUNCT
admet-2874	24	16	egf	egf	PROPN
admet-2874	24	17	,	,	PUNCT
admet-2874	24	18	and	and	CCONJ
admet-2874	24	19	igf	igf	PROPN
admet-2874	24	20	,	,	PUNCT
admet-2874	24	21	are	be	AUX
admet-2874	24	22	also	also	ADV
admet-2874	24	23	released	release	VERB
admet-2874	24	24	by	by	ADP
admet-2874	24	25	injured	injure	VERB
admet-2874	24	26	hepatocytes	hepatocyte	NOUN
admet-2874	24	27	and	and	CCONJ
admet-2874	24	28	activated	activate	VERB
admet-2874	24	29	hepatic	hepatic	ADJ
admet-2874	24	30	stellate	stellate	ADJ
admet-2874	24	31	cells	cell	NOUN
admet-2874	24	32	,	,	PUNCT
admet-2874	24	33	ultimately	ultimately	ADV
admet-2874	24	34	activating	activate	VERB
admet-2874	24	35	t	t	NOUN
admet-2874	24	36	cells	cell	NOUN
admet-2874	24	37	[	[	X
admet-2874	24	38	4	4	NUM
admet-2874	24	39	]	]	PUNCT
admet-2874	24	40	,	,	PUNCT
admet-2874	24	41	which	which	PRON
admet-2874	24	42	are	be	AUX
admet-2874	24	43	pivotal	pivotal	ADJ
admet-2874	24	44	to	to	ADP
admet-2874	24	45	both	both	DET
admet-2874	24	46	th2	th2	PROPN
admet-2874	24	47	-	-	PUNCT
admet-2874	24	48	mediated	mediate	VERB
admet-2874	24	49	fibrosis	fibrosis	NOUN
admet-2874	24	50	and	and	CCONJ
admet-2874	24	51	th17	th17	PROPN
admet-2874	24	52	-	-	PUNCT
admet-2874	24	53	mediated	mediate	VERB
admet-2874	24	54	inflammation	inflammation	NOUN
admet-2874	24	55	in	in	ADP
admet-2874	24	56	liver	liver	NOUN
admet-2874	24	57	fibrosis	fibrosis	NOUN
admet-2874	24	58	.	.	PUNCT
admet-2874	25	1	cholangiocytes	cholangiocyte	NOUN
admet-2874	25	2	are	be	AUX
admet-2874	25	3	specialized	specialized	ADJ
admet-2874	25	4	epithelial	epithelial	ADJ
admet-2874	25	5	cells	cell	NOUN
admet-2874	25	6	lining	line	VERB
admet-2874	25	7	bile	bile	NOUN
admet-2874	25	8	ducts	duct	NOUN
admet-2874	25	9	that	that	PRON
admet-2874	25	10	play	play	VERB
admet-2874	25	11	a	a	DET
admet-2874	25	12	vital	vital	ADJ
admet-2874	25	13	role	role	NOUN
admet-2874	25	14	in	in	ADP
admet-2874	25	15	liver	liver	NOUN
admet-2874	25	16	regeneration	regeneration	NOUN
admet-2874	25	17	,	,	PUNCT
admet-2874	25	18	especially	especially	ADV
admet-2874	25	19	when	when	SCONJ
admet-2874	25	20	hepatocyte	hepatocyte	NOUN
admet-2874	25	21	regeneration	regeneration	NOUN
admet-2874	25	22	is	be	AUX
admet-2874	25	23	compromised	compromise	VERB
admet-2874	25	24	[	[	PUNCT
admet-2874	25	25	5	5	NUM
admet-2874	25	26	]	]	PUNCT
admet-2874	25	27	.	.	PUNCT
admet-2874	26	1	they	they	PRON
admet-2874	26	2	also	also	ADV
admet-2874	26	3	activate	activate	VERB
admet-2874	26	4	kupffer	kupffer	NOUN
admet-2874	26	5	cells	cell	NOUN
admet-2874	26	6	and	and	CCONJ
admet-2874	26	7	release	release	VERB
admet-2874	26	8	free	free	ADJ
admet-2874	26	9	radicals	radical	NOUN
admet-2874	26	10	,	,	PUNCT
admet-2874	26	11	tnf	tnf	PROPN
admet-2874	26	12	-	-	PUNCT
admet-2874	26	13	α	α	PROPN
admet-2874	26	14	,	,	PUNCT
admet-2874	26	15	endothelin-1	endothelin-1	NOUN
admet-2874	26	16	,	,	PUNCT
admet-2874	26	17	and	and	CCONJ
admet-2874	26	18	pdgf	pdgf	NOUN
admet-2874	26	19	.	.	PUNCT
admet-2874	27	1	monocytes	monocyte	NOUN
admet-2874	27	2	also	also	ADV
admet-2874	27	3	play	play	VERB
admet-2874	27	4	a	a	DET
admet-2874	27	5	very	very	ADV
admet-2874	27	6	crucial	crucial	ADJ
admet-2874	27	7	role	role	NOUN
admet-2874	27	8	in	in	ADP
admet-2874	27	9	various	various	ADJ
admet-2874	27	10	liver	liver	NOUN
admet-2874	27	11	diseases	disease	NOUN
admet-2874	27	12	,	,	PUNCT
admet-2874	27	13	both	both	CCONJ
admet-2874	27	14	by	by	ADP
admet-2874	27	15	inflammatory	inflammatory	ADJ
admet-2874	27	16	functions	function	NOUN
admet-2874	27	17	and	and	CCONJ
admet-2874	27	18	the	the	DET
admet-2874	27	19	resolution	resolution	NOUN
admet-2874	27	20	of	of	ADP
admet-2874	27	21	inflammation	inflammation	NOUN
admet-2874	27	22	.	.	PUNCT
admet-2874	28	1	inflammatory	inflammatory	ADJ
admet-2874	28	2	mediators	mediator	NOUN
admet-2874	28	3	,	,	PUNCT
admet-2874	28	4	such	such	ADJ
admet-2874	28	5	as	as	ADP
admet-2874	28	6	ccl2	ccl2	NOUN
admet-2874	28	7	,	,	PUNCT
admet-2874	28	8	facilitate	facilitate	VERB
admet-2874	28	9	the	the	DET
admet-2874	28	10	recruitment	recruitment	NOUN
admet-2874	28	11	of	of	ADP
admet-2874	28	12	ly-6chi	ly-6chi	PROPN
admet-2874	28	13	and	and	CCONJ
admet-2874	28	14	ccr2	ccr2	PROPN
admet-2874	28	15	+	+	CCONJ
admet-2874	28	16	monocytes	monocyte	VERB
admet-2874	28	17	into	into	ADP
admet-2874	28	18	the	the	DET
admet-2874	28	19	injured	injure	VERB
admet-2874	28	20	liver	liver	NOUN
admet-2874	28	21	[	[	X
admet-2874	28	22	6	6	NUM
admet-2874	28	23	]	]	PUNCT
admet-2874	28	24	.	.	PUNCT
admet-2874	29	1	collagen	collagen	NOUN
admet-2874	29	2	is	be	AUX
admet-2874	29	3	produced	produce	VERB
admet-2874	29	4	by	by	ADP
admet-2874	29	5	ly-6c+	ly-6c+	PROPN
admet-2874	29	6	cells	cell	NOUN
admet-2874	29	7	,	,	PUNCT
admet-2874	29	8	which	which	PRON
admet-2874	29	9	also	also	ADV
admet-2874	29	10	activate	activate	VERB
admet-2874	29	11	hsc	hsc	NOUN
admet-2874	29	12	and	and	CCONJ
admet-2874	29	13	release	release	NOUN
admet-2874	29	14	pdgf	pdgf	NOUN
admet-2874	29	15	,	,	PUNCT
admet-2874	29	16	nkf	nkf	PROPN
admet-2874	29	17	β	β	PROPN
admet-2874	29	18	,	,	PUNCT
admet-2874	29	19	cd14	cd14	PROPN
admet-2874	29	20	+	+	PROPN
admet-2874	29	21	,	,	PUNCT
admet-2874	29	22	and	and	CCONJ
admet-2874	29	23	cd16	cd16	PROPN
admet-2874	29	24	+	+	PROPN
admet-2874	30	1	[	[	X
admet-2874	30	2	7	7	NUM
admet-2874	30	3	]	]	PUNCT
admet-2874	30	4	.	.	PUNCT
admet-2874	31	1	liver	liver	NOUN
admet-2874	31	2	sinusoidal	sinusoidal	NOUN
admet-2874	31	3	and	and	CCONJ
admet-2874	31	4	epithelial	epithelial	ADJ
admet-2874	31	5	cells	cell	NOUN
admet-2874	31	6	also	also	ADV
admet-2874	31	7	have	have	VERB
admet-2874	31	8	a	a	DET
admet-2874	31	9	focal	focal	ADJ
admet-2874	31	10	role	role	NOUN
admet-2874	31	11	in	in	ADP
admet-2874	31	12	liver	liver	NOUN
admet-2874	31	13	fibrosis	fibrosis	NOUN
admet-2874	31	14	after	after	ADP
admet-2874	31	15	liver	liver	NOUN
admet-2874	31	16	injury	injury	NOUN
admet-2874	31	17	,	,	PUNCT
admet-2874	31	18	as	as	SCONJ
admet-2874	31	19	these	these	DET
admet-2874	31	20	cells	cell	NOUN
admet-2874	31	21	release	release	VERB
admet-2874	31	22	endothelin-1	endothelin-1	NOUN
admet-2874	31	23	(	(	PUNCT
admet-2874	31	24	et-1	et-1	X
admet-2874	31	25	)	)	PUNCT
admet-2874	31	26	and	and	CCONJ
admet-2874	31	27	nitric	nitric	ADJ
admet-2874	31	28	oxide	oxide	NOUN
admet-2874	31	29	(	(	PUNCT
admet-2874	31	30	no	no	NOUN
admet-2874	31	31	)	)	PUNCT
admet-2874	32	1	[	[	X
admet-2874	32	2	8,9	8,9	NUM
admet-2874	32	3	]	]	PUNCT
admet-2874	32	4	.	.	PUNCT
admet-2874	32	5	fenestrae	fenestrae	NOUN
admet-2874	32	6	,	,	PUNCT
admet-2874	32	7	i.e.	i.e.	X
admet-2874	32	8	non	non	ADJ
admet-2874	32	9	-	-	ADJ
admet-2874	32	10	diaphragmed	diaphragme	VERB
admet-2874	32	11	pores	pore	NOUN
admet-2874	32	12	present	present	ADJ
admet-2874	32	13	in	in	ADP
admet-2874	32	14	them	they	PRON
admet-2874	32	15	,	,	PUNCT
admet-2874	32	16	play	play	VERB
admet-2874	32	17	an	an	DET
admet-2874	32	18	important	important	ADJ
admet-2874	32	19	role	role	NOUN
admet-2874	32	20	in	in	ADP
admet-2874	32	21	maintaining	maintain	VERB
admet-2874	32	22	the	the	DET
admet-2874	32	23	quiescent	quiescent	ADJ
admet-2874	32	24	state	state	NOUN
admet-2874	32	25	of	of	ADP
admet-2874	32	26	hsc	hsc	PROPN
admet-2874	32	27	and	and	CCONJ
admet-2874	32	28	kupffer	kupffer	NOUN
admet-2874	32	29	cells	cell	NOUN
admet-2874	32	30	,	,	PUNCT
admet-2874	32	31	essential	essential	ADJ
admet-2874	32	32	for	for	ADP
admet-2874	32	33	a	a	DET
admet-2874	32	34	healthy	healthy	ADJ
admet-2874	32	35	liver	liver	NOUN
admet-2874	32	36	.	.	PUNCT
admet-2874	33	1	natural	natural	ADJ
admet-2874	33	2	killer	killer	NOUN
admet-2874	33	3	cells	cell	NOUN
admet-2874	33	4	present	present	ADJ
admet-2874	33	5	in	in	ADP
admet-2874	33	6	the	the	DET
admet-2874	33	7	liver	liver	NOUN
admet-2874	33	8	tissue	tissue	NOUN
admet-2874	33	9	act	act	NOUN
admet-2874	33	10	on	on	ADP
admet-2874	33	11	pathogens	pathogen	NOUN
admet-2874	33	12	and	and	CCONJ
admet-2874	33	13	tumour	tumour	NOUN
admet-2874	33	14	substances	substance	NOUN
admet-2874	33	15	that	that	PRON
admet-2874	33	16	come	come	VERB
admet-2874	33	17	through	through	ADP
admet-2874	33	18	blood	blood	NOUN
admet-2874	33	19	vessels	vessel	NOUN
admet-2874	33	20	and	and	CCONJ
admet-2874	33	21	also	also	ADV
admet-2874	33	22	play	play	VERB
admet-2874	33	23	an	an	DET
admet-2874	33	24	important	important	ADJ
admet-2874	33	25	role	role	NOUN
admet-2874	33	26	in	in	ADP
admet-2874	33	27	the	the	DET
admet-2874	33	28	regulation	regulation	NOUN
admet-2874	33	29	of	of	ADP
admet-2874	33	30	inflammation	inflammation	NOUN
admet-2874	33	31	and	and	CCONJ
admet-2874	33	32	liver	liver	NOUN
admet-2874	33	33	fibrosis	fibrosis	NOUN
admet-2874	33	34	[	[	X
admet-2874	33	35	10	10	NUM
admet-2874	33	36	]	]	PUNCT
admet-2874	33	37	.	.	PUNCT
admet-2874	34	1	kupffer	kupffer	NOUN
admet-2874	34	2	cells	cell	NOUN
admet-2874	34	3	in	in	ADP
admet-2874	34	4	the	the	DET
admet-2874	34	5	liver	liver	NOUN
admet-2874	34	6	show	show	VERB
admet-2874	34	7	phagocytic	phagocytic	ADJ
admet-2874	34	8	action	action	NOUN
admet-2874	34	9	towards	towards	ADP
admet-2874	34	10	pathogens	pathogen	NOUN
admet-2874	34	11	and	and	CCONJ
admet-2874	34	12	any	any	DET
admet-2874	34	13	hazardous	hazardous	ADJ
admet-2874	34	14	substances	substance	NOUN
admet-2874	34	15	and	and	CCONJ
admet-2874	34	16	also	also	ADV
admet-2874	34	17	perform	perform	VERB
admet-2874	34	18	erythrophagocytosis	erythrophagocytosis	NOUN
admet-2874	34	19	for	for	ADP
admet-2874	34	20	senescent	senescent	ADJ
admet-2874	34	21	red	red	ADJ
admet-2874	34	22	blood	blood	NOUN
admet-2874	34	23	cells	cell	NOUN
admet-2874	34	24	.	.	PUNCT
admet-2874	35	1	after	after	ADP
admet-2874	35	2	activation	activation	NOUN
admet-2874	35	3	,	,	PUNCT
admet-2874	35	4	kupffer	kupffer	NOUN
admet-2874	35	5	cells	cell	NOUN
admet-2874	35	6	release	release	VERB
admet-2874	35	7	free	free	ADJ
admet-2874	35	8	radicals	radical	NOUN
admet-2874	35	9	and	and	CCONJ
admet-2874	35	10	inflammatory	inflammatory	ADJ
admet-2874	35	11	mediators	mediator	NOUN
admet-2874	35	12	,	,	PUNCT
admet-2874	35	13	i.e.	i.e.	X
admet-2874	35	14	tgf	tgf	PROPN
admet-2874	35	15	-	-	PUNCT
admet-2874	35	16	β1	β1	PROPN
admet-2874	35	17	,	,	PUNCT
admet-2874	35	18	tnf	tnf	PROPN
admet-2874	35	19	-	-	PUNCT
admet-2874	35	20	α	α	PROPN
admet-2874	35	21	,	,	PUNCT
admet-2874	35	22	and	and	CCONJ
admet-2874	35	23	igf	igf	PROPN
admet-2874	36	1	[	[	X
admet-2874	36	2	11	11	NUM
admet-2874	36	3	]	]	PUNCT
admet-2874	36	4	.	.	PUNCT
admet-2874	37	1	recently	recently	ADV
admet-2874	37	2	,	,	PUNCT
admet-2874	37	3	the	the	DET
admet-2874	37	4	role	role	NOUN
admet-2874	37	5	of	of	ADP
admet-2874	37	6	kupffer	kupffer	NOUN
admet-2874	37	7	cell	cell	NOUN
admet-2874	37	8	pyroptosis	pyroptosis	NOUN
admet-2874	37	9	has	have	AUX
admet-2874	37	10	also	also	ADV
admet-2874	37	11	been	be	AUX
admet-2874	37	12	explored	explore	VERB
admet-2874	37	13	by	by	ADP
admet-2874	37	14	researchers	researcher	NOUN
admet-2874	37	15	,	,	PUNCT
admet-2874	37	16	demonstrating	demonstrate	VERB
admet-2874	37	17	its	its	PRON
admet-2874	37	18	role	role	NOUN
admet-2874	37	19	in	in	ADP
admet-2874	37	20	promoting	promote	VERB
admet-2874	37	21	liver	liver	NOUN
admet-2874	37	22	injury	injury	NOUN
admet-2874	37	23	and	and	CCONJ
admet-2874	37	24	inflammation	inflammation	NOUN
admet-2874	37	25	,	,	PUNCT
admet-2874	37	26	leading	lead	VERB
admet-2874	37	27	to	to	ADP
admet-2874	37	28	liver	liver	NOUN
admet-2874	37	29	fibrosis	fibrosis	NOUN
admet-2874	37	30	via	via	ADP
admet-2874	37	31	the	the	DET
admet-2874	37	32	nox2	nox2	PROPN
admet-2874	37	33	/	/	SYM
admet-2874	37	34	nlrp3	nlrp3	NOUN
admet-2874	37	35	inflammasome	inflammasome	NOUN
admet-2874	37	36	pathway	pathway	NOUN
admet-2874	38	1	[	[	X
admet-2874	38	2	12	12	NUM
admet-2874	38	3	]	]	PUNCT
admet-2874	38	4	.	.	PUNCT
admet-2874	39	1	in	in	ADP
admet-2874	39	2	cld	cld	NOUN
admet-2874	39	3	associated	associate	VERB
admet-2874	39	4	with	with	ADP
admet-2874	39	5	hbv	hbv	NOUN
admet-2874	39	6	and	and	CCONJ
admet-2874	39	7	hcv	hcv	NOUN
admet-2874	39	8	,	,	PUNCT
admet-2874	39	9	th17	th17	PROPN
admet-2874	39	10	lymphocytes	lymphocyte	NOUN
admet-2874	39	11	,	,	PUNCT
admet-2874	39	12	a	a	DET
admet-2874	39	13	subgroup	subgroup	NOUN
admet-2874	39	14	of	of	ADP
admet-2874	39	15	t	t	PROPN
admet-2874	39	16	helper	helper	NOUN
admet-2874	39	17	cells	cell	NOUN
admet-2874	39	18	that	that	PRON
admet-2874	39	19	release	release	VERB
admet-2874	39	20	the	the	DET
admet-2874	39	21	pro	pro	ADJ
admet-2874	39	22	-	-	ADJ
admet-2874	39	23	inflammatory	inflammatory	ADJ
admet-2874	39	24	il-17a	il-17a	PROPN
admet-2874	39	25	,	,	PUNCT
admet-2874	39	26	may	may	AUX
admet-2874	39	27	possess	possess	VERB
admet-2874	39	28	pro	pro	ADJ
admet-2874	39	29	-	-	ADJ
admet-2874	39	30	fibrogenic	fibrogenic	ADJ
admet-2874	39	31	properties	property	NOUN
admet-2874	39	32	.	.	PUNCT
admet-2874	40	1	besides	besides	SCONJ
admet-2874	40	2	,	,	PUNCT
admet-2874	40	3	the	the	DET
admet-2874	40	4	appearance	appearance	NOUN
admet-2874	40	5	of	of	ADP
admet-2874	40	6	oxidative	oxidative	ADJ
admet-2874	40	7	stress	stress	NOUN
admet-2874	40	8	,	,	PUNCT
admet-2874	40	9	either	either	CCONJ
admet-2874	40	10	as	as	ADP
admet-2874	40	11	a	a	DET
admet-2874	40	12	consequence	consequence	NOUN
admet-2874	40	13	of	of	ADP
admet-2874	40	14	excessive	excessive	ADJ
admet-2874	40	15	production	production	NOUN
admet-2874	40	16	of	of	ADP
admet-2874	40	17	reactive	reactive	ADJ
admet-2874	40	18	oxygen	oxygen	NOUN
admet-2874	40	19	species	specie	NOUN
admet-2874	40	20	or	or	CCONJ
admet-2874	40	21	deficiency	deficiency	NOUN
admet-2874	40	22	of	of	ADP
admet-2874	40	23	the	the	DET
admet-2874	40	24	antioxidant	antioxidant	ADJ
admet-2874	40	25	defence	defence	NOUN
admet-2874	40	26	system	system	NOUN
admet-2874	40	27	,	,	PUNCT
admet-2874	40	28	can	can	AUX
admet-2874	40	29	wreak	wreak	VERB
admet-2874	40	30	havoc	havoc	NOUN
admet-2874	40	31	in	in	ADP
admet-2874	40	32	the	the	DET
admet-2874	40	33	form	form	NOUN
admet-2874	40	34	of	of	ADP
admet-2874	40	35	liver	liver	NOUN
admet-2874	40	36	fibrosis	fibrosis	NOUN
admet-2874	40	37	upon	upon	SCONJ
admet-2874	40	38	activating	activate	VERB
admet-2874	40	39	the	the	DET
admet-2874	40	40	hscs	hsc	NOUN
admet-2874	40	41	.	.	PUNCT
admet-2874	41	1	the	the	DET
admet-2874	41	2	activated	activate	VERB
admet-2874	41	3	hscs	hsc	NOUN
admet-2874	41	4	initiated	initiate	VERB
admet-2874	41	5	by	by	ADP
admet-2874	41	6	oxidative	oxidative	ADJ
admet-2874	41	7	damage	damage	NOUN
admet-2874	41	8	can	can	AUX
admet-2874	41	9	be	be	AUX
admet-2874	41	10	detrimental	detrimental	ADJ
admet-2874	41	11	,	,	PUNCT
admet-2874	41	12	and	and	CCONJ
admet-2874	41	13	,	,	PUNCT
admet-2874	41	14	hence	hence	ADV
admet-2874	41	15	,	,	PUNCT
admet-2874	41	16	another	another	DET
admet-2874	41	17	related	related	ADJ
admet-2874	41	18	phenomenon	phenomenon	NOUN
admet-2874	41	19	,	,	PUNCT
admet-2874	41	20	mitochondrial	mitochondrial	ADJ
admet-2874	41	21	dysfunction	dysfunction	NOUN
admet-2874	41	22	,	,	PUNCT
admet-2874	41	23	comes	come	VERB
admet-2874	41	24	into	into	ADP
admet-2874	41	25	play	play	NOUN
admet-2874	41	26	to	to	PART
admet-2874	41	27	exacerbate	exacerbate	VERB
admet-2874	41	28	the	the	DET
admet-2874	41	29	condition	condition	NOUN
admet-2874	41	30	due	due	ADJ
admet-2874	41	31	to	to	ADP
admet-2874	41	32	disrupted	disrupt	VERB
admet-2874	41	33	energy	energy	NOUN
admet-2874	41	34	generation	generation	NOUN
admet-2874	41	35	and	and	CCONJ
admet-2874	41	36	metabolic	metabolic	NOUN
admet-2874	41	37	processes	process	NOUN
admet-2874	41	38	,	,	PUNCT
admet-2874	41	39	leading	lead	VERB
admet-2874	41	40	to	to	ADP
admet-2874	41	41	apoptosis	apoptosis	NOUN
admet-2874	41	42	and	and	CCONJ
admet-2874	41	43	liver	liver	NOUN
admet-2874	41	44	damage	damage	NOUN
admet-2874	41	45	[	[	X
admet-2874	41	46	13	13	NUM
admet-2874	41	47	]	]	PUNCT
admet-2874	41	48	.	.	PUNCT
admet-2874	42	1	overall	overall	ADV
admet-2874	42	2	,	,	PUNCT
admet-2874	42	3	this	this	DET
admet-2874	42	4	review	review	NOUN
admet-2874	42	5	presents	present	VERB
admet-2874	42	6	recent	recent	ADJ
admet-2874	42	7	and	and	CCONJ
admet-2874	42	8	novel	novel	ADJ
admet-2874	42	9	advancements	advancement	NOUN
admet-2874	42	10	in	in	ADP
admet-2874	42	11	understanding	understand	VERB
admet-2874	42	12	the	the	DET
admet-2874	42	13	pathogenesis	pathogenesis	NOUN
admet-2874	42	14	of	of	ADP
admet-2874	42	15	liver	liver	NOUN
admet-2874	42	16	fibrosis	fibrosis	NOUN
admet-2874	42	17	,	,	PUNCT
admet-2874	42	18	emphasizing	emphasize	VERB
admet-2874	42	19	the	the	DET
admet-2874	42	20	major	major	ADJ
admet-2874	42	21	cell	cell	NOUN
admet-2874	42	22	types	type	NOUN
admet-2874	42	23	involved	involve	VERB
admet-2874	42	24	,	,	PUNCT
admet-2874	42	25	with	with	ADP
admet-2874	42	26	a	a	DET
admet-2874	42	27	particular	particular	ADJ
admet-2874	42	28	focus	focus	NOUN
admet-2874	42	29	on	on	ADP
admet-2874	42	30	hepatic	hepatic	ADJ
admet-2874	42	31	stellate	stellate	ADJ
admet-2874	42	32	cells	cell	NOUN
admet-2874	42	33	(	(	PUNCT
admet-2874	42	34	hscs	hsc	NOUN
admet-2874	42	35	)	)	PUNCT
admet-2874	42	36	.	.	PUNCT
admet-2874	43	1	it	it	PRON
admet-2874	43	2	consolidates	consolidate	VERB
admet-2874	43	3	recent	recent	ADJ
admet-2874	43	4	clinical	clinical	ADJ
admet-2874	43	5	trial	trial	NOUN
admet-2874	43	6	data	datum	NOUN
admet-2874	43	7	,	,	PUNCT
admet-2874	43	8	as	as	ADV
admet-2874	43	9	well	well	ADV
admet-2874	43	10	as	as	ADP
admet-2874	43	11	clinical	clinical	ADJ
admet-2874	43	12	and	and	CCONJ
admet-2874	43	13	experimental	experimental	ADJ
admet-2874	43	14	approaches	approach	NOUN
admet-2874	43	15	that	that	PRON
admet-2874	43	16	target	target	VERB
admet-2874	43	17	fibrosis	fibrosis	NOUN
admet-2874	43	18	.	.	PUNCT
admet-2874	44	1	additionally	additionally	ADV
admet-2874	44	2	,	,	PUNCT
admet-2874	44	3	it	it	PRON
admet-2874	44	4	explores	explore	VERB
admet-2874	44	5	delivery	delivery	NOUN
admet-2874	44	6	systems	system	NOUN
admet-2874	44	7	through	through	ADP
admet-2874	44	8	active	active	ADJ
admet-2874	44	9	and	and	CCONJ
admet-2874	44	10	passive	passive	ADJ
admet-2874	44	11	targeting	targeting	NOUN
admet-2874	44	12	mechanisms	mechanism	NOUN
admet-2874	44	13	.	.	PUNCT
admet-2874	45	1	lastly	lastly	ADV
admet-2874	45	2	,	,	PUNCT
admet-2874	45	3	future	future	ADJ
admet-2874	45	4	perspectives	perspective	NOUN
admet-2874	45	5	are	be	AUX
admet-2874	45	6	also	also	ADV
admet-2874	45	7	discussed	discuss	VERB
admet-2874	45	8	,	,	PUNCT
admet-2874	45	9	highlighting	highlight	VERB
admet-2874	45	10	promising	promising	ADJ
admet-2874	45	11	strategies	strategy	NOUN
admet-2874	45	12	for	for	ADP
admet-2874	45	13	the	the	DET
admet-2874	45	14	development	development	NOUN
admet-2874	45	15	of	of	ADP
admet-2874	45	16	effective	effective	ADJ
admet-2874	45	17	antifibrotic	antifibrotic	ADJ
admet-2874	45	18	therapies	therapy	NOUN
admet-2874	45	19	.	.	PUNCT
admet-2874	46	1	role	role	NOUN
admet-2874	46	2	of	of	ADP
admet-2874	46	3	hepatic	hepatic	ADJ
admet-2874	46	4	stellate	stellate	ADJ
admet-2874	46	5	cells	cell	NOUN
admet-2874	46	6	in	in	ADP
admet-2874	46	7	healthy	healthy	ADJ
admet-2874	46	8	liver	liver	NOUN
admet-2874	46	9	and	and	CCONJ
admet-2874	46	10	liver	liver	NOUN
admet-2874	46	11	fibrosis	fibrosis	NOUN
admet-2874	46	12	in	in	ADP
admet-2874	46	13	a	a	DET
admet-2874	46	14	healthy	healthy	ADJ
admet-2874	46	15	liver	liver	NOUN
admet-2874	46	16	,	,	PUNCT
admet-2874	46	17	hepatic	hepatic	ADJ
admet-2874	46	18	stellate	stellate	ADJ
admet-2874	46	19	cells	cell	NOUN
admet-2874	46	20	(	(	PUNCT
admet-2874	46	21	hscs	hsc	NOUN
admet-2874	46	22	)	)	PUNCT
admet-2874	46	23	play	play	VERB
admet-2874	46	24	a	a	DET
admet-2874	46	25	crucial	crucial	ADJ
admet-2874	46	26	role	role	NOUN
admet-2874	46	27	in	in	ADP
admet-2874	46	28	liver	liver	NOUN
admet-2874	46	29	development	development	NOUN
admet-2874	46	30	,	,	PUNCT
admet-2874	46	31	homeostasis	homeostasis	NOUN
admet-2874	46	32	,	,	PUNCT
admet-2874	46	33	and	and	CCONJ
admet-2874	46	34	regeneration	regeneration	NOUN
admet-2874	46	35	.	.	PUNCT
admet-2874	47	1	vitamin	vitamin	NOUN
admet-2874	47	2	a	a	PRON
admet-2874	47	3	is	be	AUX
admet-2874	47	4	stored	store	VERB
admet-2874	47	5	by	by	ADP
admet-2874	47	6	hscs	hsc	NOUN
admet-2874	47	7	in	in	ADP
admet-2874	47	8	the	the	DET
admet-2874	47	9	form	form	NOUN
admet-2874	47	10	of	of	ADP
admet-2874	47	11	retinyl	retinyl	NOUN
admet-2874	47	12	esters	ester	NOUN
admet-2874	47	13	,	,	PUNCT
admet-2874	47	14	located	locate	VERB
admet-2874	47	15	near	near	ADP
admet-2874	47	16	the	the	DET
admet-2874	47	17	nucleus	nucleus	NOUN
admet-2874	47	18	in	in	ADP
admet-2874	47	19	the	the	DET
admet-2874	47	20	form	form	NOUN
admet-2874	47	21	of	of	ADP
admet-2874	47	22	lipid	lipid	ADJ
admet-2874	47	23	droplets	droplet	NOUN
admet-2874	47	24	.	.	PUNCT
admet-2874	48	1	the	the	DET
admet-2874	48	2	gut	gut	NOUN
admet-2874	48	3	absorbs	absorb	VERB
admet-2874	48	4	dietary	dietary	ADJ
admet-2874	48	5	retinoids	retinoid	NOUN
admet-2874	48	6	,	,	PUNCT
admet-2874	48	7	which	which	PRON
admet-2874	48	8	are	be	AUX
admet-2874	48	9	then	then	ADV
admet-2874	48	10	carried	carry	VERB
admet-2874	48	11	to	to	ADP
admet-2874	48	12	hepatocytes	hepatocytes	PROPN
admet-2874	48	13	as	as	ADP
admet-2874	48	14	retinyl	retinyl	NOUN
admet-2874	48	15	esters	ester	NOUN
admet-2874	48	16	and	and	CCONJ
admet-2874	48	17	broken	break	VERB
admet-2874	48	18	down	down	ADP
admet-2874	48	19	into	into	ADP
admet-2874	48	20	free	free	ADJ
admet-2874	48	21	retinol	retinol	NOUN
admet-2874	48	22	.	.	PUNCT
admet-2874	49	1	vitamin	vitamin	NOUN
admet-2874	49	2	a	a	PRON
admet-2874	49	3	is	be	AUX
admet-2874	49	4	then	then	ADV
admet-2874	49	5	delivered	deliver	VERB
admet-2874	49	6	to	to	ADP
admet-2874	49	7	hscs	hsc	NOUN
admet-2874	49	8	for	for	ADP
admet-2874	49	9	re	re	NOUN
admet-2874	49	10	-	-	NOUN
admet-2874	49	11	esterification	esterification	NOUN
admet-2874	49	12	,	,	PUNCT
admet-2874	49	13	with	with	ADP
admet-2874	49	14	perilipins	perilipin	NOUN
admet-2874	49	15	coating	coat	VERB
admet-2874	49	16	these	these	DET
admet-2874	49	17	lipid	lipid	NOUN
admet-2874	49	18	droplets	droplet	NOUN
admet-2874	49	19	[	[	X
admet-2874	49	20	14	14	NUM
admet-2874	49	21	]	]	PUNCT
admet-2874	49	22	.	.	PUNCT
admet-2874	50	1	adipose	adipose	NOUN
admet-2874	50	2	-	-	PUNCT
admet-2874	50	3	differentiation	differentiation	NOUN
admet-2874	50	4	-	-	PUNCT
admet-2874	50	5	related	relate	VERB
admet-2874	50	6	protein	protein	NOUN
admet-2874	50	7	is	be	AUX
admet-2874	50	8	also	also	ADV
admet-2874	50	9	expressed	express	VERB
admet-2874	50	10	by	by	ADP
admet-2874	50	11	hscs	hsc	NOUN
admet-2874	50	12	,	,	PUNCT
admet-2874	50	13	although	although	SCONJ
admet-2874	50	14	its	its	PRON
admet-2874	50	15	expression	expression	NOUN
admet-2874	50	16	declines	decline	VERB
admet-2874	50	17	as	as	SCONJ
admet-2874	50	18	the	the	DET
admet-2874	50	19	cells	cell	NOUN
admet-2874	50	20	produce	produce	VERB
admet-2874	50	21	and	and	CCONJ
admet-2874	50	22	shed	shed	VERB
admet-2874	50	23	retinoid	retinoid	NOUN
admet-2874	50	24	droplets	droplet	NOUN
admet-2874	50	25	[	[	X
admet-2874	50	26	15	15	NUM
admet-2874	50	27	]	]	PUNCT
admet-2874	50	28	.	.	PUNCT
admet-2874	51	1	furthermore	furthermore	ADV
admet-2874	51	2	,	,	PUNCT
admet-2874	51	3	during	during	ADP
admet-2874	51	4	liver	liver	NOUN
admet-2874	51	5	injury	injury	NOUN
admet-2874	51	6	,	,	PUNCT
admet-2874	51	7	matrix	matrix	NOUN
admet-2874	51	8	admet	admet	PROPN
admet-2874	51	9	&	&	CCONJ
admet-2874	51	10	dmpk	dmpk	PROPN
admet-2874	51	11	13(4	13(4	NUM
admet-2874	51	12	)	)	PUNCT
admet-2874	51	13	(	(	PUNCT
admet-2874	51	14	2025	2025	NUM
admet-2874	51	15	)	)	PUNCT
admet-2874	51	16	2874	2874	NUM
admet-2874	51	17	hscs	hsc	NOUN
admet-2874	51	18	in	in	ADP
admet-2874	51	19	liver	liver	NOUN
admet-2874	51	20	fibrosis	fibrosis	NOUN
admet-2874	51	21	:	:	PUNCT
admet-2874	51	22	therapeutic	therapeutic	ADJ
admet-2874	51	23	advances	advance	NOUN
admet-2874	51	24	doi	doi	NOUN
admet-2874	51	25	:	:	PUNCT
admet-2874	51	26	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PUNCT
admet-2874	51	27	3	3	NUM
admet-2874	51	28	remodelling	remodelling	NOUN
admet-2874	51	29	is	be	AUX
admet-2874	51	30	regulated	regulate	VERB
admet-2874	51	31	by	by	ADP
admet-2874	51	32	matrix	matrix	NOUN
admet-2874	51	33	metalloproteinases	metalloproteinase	NOUN
admet-2874	51	34	(	(	PUNCT
admet-2874	51	35	mmps	mmp	NOUN
admet-2874	51	36	)	)	PUNCT
admet-2874	51	37	secreted	secrete	VERB
admet-2874	51	38	by	by	ADP
admet-2874	51	39	hscs	hsc	NOUN
admet-2874	51	40	.	.	PUNCT
admet-2874	52	1	however	however	ADV
admet-2874	52	2	,	,	PUNCT
admet-2874	52	3	tissue	tissue	NOUN
admet-2874	52	4	inhibitors	inhibitor	NOUN
admet-2874	52	5	of	of	ADP
admet-2874	52	6	metalloproteinases	metalloproteinase	NOUN
admet-2874	52	7	(	(	PUNCT
admet-2874	52	8	timps	timp	NOUN
admet-2874	52	9	)	)	PUNCT
admet-2874	52	10	,	,	PUNCT
admet-2874	52	11	which	which	PRON
admet-2874	52	12	are	be	AUX
admet-2874	52	13	also	also	ADV
admet-2874	52	14	released	release	VERB
admet-2874	52	15	by	by	ADP
admet-2874	52	16	activated	activate	VERB
admet-2874	52	17	hscs	hsc	NOUN
admet-2874	52	18	(	(	PUNCT
admet-2874	52	19	ahscs	ahsc	NOUN
admet-2874	52	20	)	)	PUNCT
admet-2874	52	21	,	,	PUNCT
admet-2874	52	22	downregulate	downregulate	PROPN
admet-2874	52	23	mmp	mmp	PROPN
admet-2874	52	24	activity	activity	NOUN
admet-2874	52	25	,	,	PUNCT
admet-2874	52	26	leading	lead	VERB
admet-2874	52	27	to	to	ADP
admet-2874	52	28	extracellular	extracellular	ADJ
admet-2874	52	29	matrix	matrix	NOUN
admet-2874	52	30	accumulation	accumulation	NOUN
admet-2874	52	31	and	and	CCONJ
admet-2874	52	32	fibrosis	fibrosis	NOUN
admet-2874	53	1	[	[	X
admet-2874	53	2	16,17	16,17	NUM
admet-2874	53	3	]	]	PUNCT
admet-2874	53	4	.	.	PUNCT
admet-2874	54	1	additionally	additionally	ADV
admet-2874	54	2	,	,	PUNCT
admet-2874	54	3	tmps	tmp	NOUN
admet-2874	54	4	promote	promote	VERB
admet-2874	54	5	the	the	DET
admet-2874	54	6	formation	formation	NOUN
admet-2874	54	7	of	of	ADP
admet-2874	54	8	collagen	collagen	NOUN
admet-2874	54	9	i	i	PRON
admet-2874	54	10	in	in	ADP
admet-2874	54	11	hscs	hsc	NOUN
admet-2874	54	12	by	by	ADP
admet-2874	54	13	activating	activate	VERB
admet-2874	54	14	tgf	tgf	PROPN
admet-2874	54	15	-	-	PUNCT
admet-2874	54	16	β	β	NOUN
admet-2874	54	17	,	,	PUNCT
admet-2874	54	18	a	a	DET
admet-2874	54	19	potent	potent	ADJ
admet-2874	54	20	stimulant	stimulant	NOUN
admet-2874	54	21	[	[	X
admet-2874	54	22	18	18	NUM
admet-2874	54	23	]	]	PUNCT
admet-2874	54	24	.	.	PUNCT
admet-2874	55	1	hscs	hsc	NOUN
admet-2874	55	2	also	also	ADV
admet-2874	55	3	secrete	secrete	VERB
admet-2874	55	4	growth	growth	NOUN
admet-2874	55	5	factors	factor	NOUN
admet-2874	55	6	such	such	ADJ
admet-2874	55	7	as	as	ADP
admet-2874	55	8	vascular	vascular	ADJ
admet-2874	55	9	endothelial	endothelial	ADJ
admet-2874	55	10	growth	growth	NOUN
admet-2874	55	11	factor	factor	NOUN
admet-2874	55	12	(	(	PUNCT
admet-2874	55	13	vegf	vegf	PROPN
admet-2874	55	14	)	)	PUNCT
admet-2874	55	15	,	,	PUNCT
admet-2874	55	16	which	which	PRON
admet-2874	55	17	plays	play	VERB
admet-2874	55	18	a	a	DET
admet-2874	55	19	key	key	ADJ
admet-2874	55	20	role	role	NOUN
admet-2874	55	21	in	in	ADP
admet-2874	55	22	endothelial	endothelial	ADJ
admet-2874	55	23	and	and	CCONJ
admet-2874	55	24	epithelial	epithelial	ADJ
admet-2874	55	25	cell	cell	NOUN
admet-2874	55	26	division	division	NOUN
admet-2874	55	27	[	[	X
admet-2874	55	28	19	19	NUM
admet-2874	55	29	]	]	PUNCT
admet-2874	55	30	.	.	PUNCT
admet-2874	56	1	hscs	hsc	NOUN
admet-2874	56	2	also	also	ADV
admet-2874	56	3	express	express	VERB
admet-2874	56	4	neurotrophins	neurotrophin	NOUN
admet-2874	56	5	,	,	PUNCT
admet-2874	56	6	including	include	VERB
admet-2874	56	7	nerve	nerve	NOUN
admet-2874	56	8	growth	growth	NOUN
admet-2874	56	9	factor	factor	NOUN
admet-2874	56	10	(	(	PUNCT
admet-2874	56	11	ngf	ngf	NOUN
admet-2874	56	12	)	)	PUNCT
admet-2874	56	13	,	,	PUNCT
admet-2874	56	14	brain	brain	NOUN
admet-2874	56	15	-	-	PUNCT
admet-2874	56	16	derived	derive	VERB
admet-2874	56	17	neurotrophic	neurotrophic	ADJ
admet-2874	56	18	factor	factor	NOUN
admet-2874	56	19	(	(	PUNCT
admet-2874	56	20	bdnf	bdnf	PROPN
admet-2874	56	21	)	)	PUNCT
admet-2874	56	22	,	,	PUNCT
admet-2874	56	23	and	and	CCONJ
admet-2874	56	24	neurotrophin-3	neurotrophin-3	PROPN
admet-2874	56	25	,	,	PUNCT
admet-2874	56	26	which	which	PRON
admet-2874	56	27	are	be	AUX
admet-2874	56	28	important	important	ADJ
admet-2874	56	29	for	for	ADP
admet-2874	56	30	liver	liver	NOUN
admet-2874	56	31	function	function	NOUN
admet-2874	56	32	and	and	CCONJ
admet-2874	56	33	regeneration	regeneration	NOUN
admet-2874	56	34	[	[	X
admet-2874	56	35	20,21	20,21	NUM
admet-2874	56	36	]	]	PUNCT
admet-2874	56	37	.	.	PUNCT
admet-2874	57	1	additionally	additionally	ADV
admet-2874	57	2	,	,	PUNCT
admet-2874	57	3	hscs	hsc	NOUN
admet-2874	57	4	contribute	contribute	VERB
admet-2874	57	5	to	to	ADP
admet-2874	57	6	ethanol	ethanol	NOUN
admet-2874	57	7	detoxification	detoxification	NOUN
admet-2874	57	8	by	by	ADP
admet-2874	57	9	expressing	express	VERB
admet-2874	57	10	alcoholand	alcoholand	ADJ
admet-2874	57	11	acetaldehyde	acetaldehyde	NOUN
admet-2874	57	12	dehydrogenases	dehydrogenase	NOUN
admet-2874	57	13	,	,	PUNCT
admet-2874	57	14	although	although	SCONJ
admet-2874	57	15	their	their	PRON
admet-2874	57	16	role	role	NOUN
admet-2874	57	17	in	in	ADP
admet-2874	57	18	this	this	DET
admet-2874	57	19	process	process	NOUN
admet-2874	57	20	is	be	AUX
admet-2874	57	21	limited	limit	VERB
admet-2874	57	22	compared	compare	VERB
admet-2874	57	23	to	to	ADP
admet-2874	57	24	hepatocytes	hepatocytes	PROPN
admet-2874	57	25	[	[	X
admet-2874	57	26	22	22	NUM
admet-2874	57	27	]	]	PUNCT
admet-2874	57	28	.	.	PUNCT
admet-2874	58	1	overall	overall	ADJ
admet-2874	58	2	,	,	PUNCT
admet-2874	58	3	in	in	ADP
admet-2874	58	4	both	both	CCONJ
admet-2874	58	5	healthy	healthy	ADJ
admet-2874	58	6	and	and	CCONJ
admet-2874	58	7	injured	injured	ADJ
admet-2874	58	8	livers	liver	NOUN
admet-2874	58	9	,	,	PUNCT
admet-2874	58	10	hscs	hsc	NOUN
admet-2874	58	11	control	control	NOUN
admet-2874	58	12	ecm	ecm	NOUN
admet-2874	58	13	remodelling	remodelling	NOUN
admet-2874	58	14	,	,	PUNCT
admet-2874	58	15	play	play	VERB
admet-2874	58	16	a	a	DET
admet-2874	58	17	role	role	NOUN
admet-2874	58	18	in	in	ADP
admet-2874	58	19	tissue	tissue	NOUN
admet-2874	58	20	healing	healing	NOUN
admet-2874	58	21	,	,	PUNCT
admet-2874	58	22	and	and	CCONJ
admet-2874	58	23	maintain	maintain	VERB
admet-2874	58	24	liver	liver	NOUN
admet-2874	58	25	homeostasis	homeostasis	NOUN
admet-2874	58	26	.	.	PUNCT
admet-2874	59	1	hsc	hsc	NOUN
admet-2874	59	2	activation	activation	NOUN
admet-2874	59	3	is	be	AUX
admet-2874	59	4	divided	divide	VERB
admet-2874	59	5	into	into	ADP
admet-2874	59	6	two	two	NUM
admet-2874	59	7	main	main	ADJ
admet-2874	59	8	phases	phase	NOUN
admet-2874	59	9	:	:	PUNCT
admet-2874	59	10	initiation	initiation	NOUN
admet-2874	59	11	,	,	PUNCT
admet-2874	59	12	often	often	ADV
admet-2874	59	13	referred	refer	VERB
admet-2874	59	14	to	to	ADP
admet-2874	59	15	as	as	ADP
admet-2874	59	16	the	the	DET
admet-2874	59	17	pre	pre	ADJ
admet-2874	59	18	-	-	ADJ
admet-2874	59	19	inflammatory	inflammatory	ADJ
admet-2874	59	20	stage	stage	NOUN
admet-2874	59	21	,	,	PUNCT
admet-2874	59	22	and	and	CCONJ
admet-2874	59	23	perpetuation	perpetuation	NOUN
admet-2874	59	24	.	.	PUNCT
admet-2874	60	1	they	they	PRON
admet-2874	60	2	may	may	AUX
admet-2874	60	3	return	return	VERB
admet-2874	60	4	to	to	ADP
admet-2874	60	5	a	a	DET
admet-2874	60	6	quiescent	quiescent	ADJ
admet-2874	60	7	state	state	NOUN
admet-2874	60	8	if	if	SCONJ
admet-2874	60	9	liver	liver	NOUN
admet-2874	60	10	injury	injury	NOUN
admet-2874	60	11	is	be	AUX
admet-2874	60	12	healed	heal	VERB
admet-2874	60	13	[	[	PUNCT
admet-2874	60	14	23	23	NUM
admet-2874	60	15	]	]	PUNCT
admet-2874	60	16	.	.	PUNCT
admet-2874	61	1	during	during	ADP
admet-2874	61	2	the	the	DET
admet-2874	61	3	initiation	initiation	NOUN
admet-2874	61	4	phase	phase	NOUN
admet-2874	61	5	,	,	PUNCT
admet-2874	61	6	endothelial	endothelial	ADJ
admet-2874	61	7	cells	cell	NOUN
admet-2874	61	8	in	in	ADP
admet-2874	61	9	the	the	DET
admet-2874	61	10	sinusoids	sinusoid	NOUN
admet-2874	61	11	play	play	VERB
admet-2874	61	12	a	a	DET
admet-2874	61	13	critical	critical	ADJ
admet-2874	61	14	role	role	NOUN
admet-2874	61	15	by	by	ADP
admet-2874	61	16	secreting	secrete	VERB
admet-2874	61	17	fibronectin	fibronectin	NOUN
admet-2874	61	18	[	[	X
admet-2874	61	19	24	24	NUM
admet-2874	61	20	]	]	PUNCT
admet-2874	61	21	and	and	CCONJ
admet-2874	61	22	activating	activate	VERB
admet-2874	61	23	latent	latent	PROPN
admet-2874	61	24	tgf	tgf	PROPN
admet-2874	61	25	-	-	PUNCT
admet-2874	61	26	β	β	PROPN
admet-2874	62	1	[	[	X
admet-2874	62	2	25	25	NUM
admet-2874	62	3	]	]	PUNCT
admet-2874	62	4	.	.	PUNCT
admet-2874	63	1	platelets	platelet	NOUN
admet-2874	63	2	contribute	contribute	VERB
admet-2874	63	3	to	to	ADP
admet-2874	63	4	this	this	DET
admet-2874	63	5	process	process	NOUN
admet-2874	63	6	by	by	ADP
admet-2874	63	7	producing	produce	VERB
admet-2874	63	8	tgf	tgf	PROPN
admet-2874	63	9	-	-	PUNCT
admet-2874	63	10	β	β	PROPN
admet-2874	63	11	,	,	PUNCT
admet-2874	63	12	egf	egf	PROPN
admet-2874	63	13	,	,	PUNCT
admet-2874	63	14	and	and	CCONJ
admet-2874	63	15	pdgf	pdgf	NOUN
admet-2874	63	16	.	.	PUNCT
admet-2874	64	1	further	far	ADV
admet-2874	64	2	,	,	PUNCT
admet-2874	64	3	the	the	DET
admet-2874	64	4	latter	latter	ADJ
admet-2874	64	5	is	be	AUX
admet-2874	64	6	a	a	DET
admet-2874	64	7	potent	potent	ADJ
admet-2874	64	8	mitogen	mitogen	NOUN
admet-2874	64	9	for	for	ADP
admet-2874	64	10	hscs	hsc	NOUN
admet-2874	64	11	[	[	X
admet-2874	64	12	26	26	NUM
admet-2874	64	13	]	]	PUNCT
admet-2874	64	14	.	.	PUNCT
admet-2874	65	1	additionally	additionally	ADV
admet-2874	65	2	,	,	PUNCT
admet-2874	65	3	various	various	ADJ
admet-2874	65	4	immune	immune	ADJ
admet-2874	65	5	cells	cell	NOUN
admet-2874	65	6	,	,	PUNCT
admet-2874	65	7	including	include	VERB
admet-2874	65	8	t	t	NOUN
admet-2874	65	9	cells	cell	NOUN
admet-2874	65	10	,	,	PUNCT
admet-2874	65	11	dendritic	dendritic	ADJ
admet-2874	65	12	cells	cell	NOUN
admet-2874	65	13	,	,	PUNCT
admet-2874	65	14	and	and	CCONJ
admet-2874	65	15	macrophages	macrophage	NOUN
admet-2874	65	16	,	,	PUNCT
admet-2874	65	17	interact	interact	VERB
admet-2874	65	18	with	with	ADP
admet-2874	65	19	hscs	hsc	NOUN
admet-2874	65	20	to	to	PART
admet-2874	65	21	modulate	modulate	VERB
admet-2874	65	22	inflammation	inflammation	NOUN
admet-2874	65	23	and	and	CCONJ
admet-2874	65	24	fibrosis	fibrosis	NOUN
admet-2874	65	25	[	[	X
admet-2874	65	26	27	27	NUM
admet-2874	65	27	]	]	PUNCT
admet-2874	65	28	.	.	PUNCT
admet-2874	66	1	for	for	ADP
admet-2874	66	2	instance	instance	NOUN
admet-2874	66	3	,	,	PUNCT
admet-2874	66	4	macrophages	macrophage	NOUN
admet-2874	66	5	secrete	secrete	NOUN
admet-2874	66	6	tgf	tgf	PROPN
admet-2874	66	7	-	-	PUNCT
admet-2874	66	8	β	β	PROPN
admet-2874	66	9	,	,	PUNCT
admet-2874	66	10	tnf	tnf	PROPN
admet-2874	66	11	-	-	PUNCT
admet-2874	66	12	α	α	PROPN
admet-2874	66	13	,	,	PUNCT
admet-2874	66	14	mmp-9	mmp-9	NOUN
admet-2874	66	15	,	,	PUNCT
admet-2874	66	16	and	and	CCONJ
admet-2874	66	17	ros	ros	PROPN
admet-2874	66	18	,	,	PUNCT
admet-2874	66	19	which	which	PRON
admet-2874	66	20	contribute	contribute	VERB
admet-2874	66	21	to	to	ADP
admet-2874	66	22	hsc	hsc	NOUN
admet-2874	66	23	activation	activation	NOUN
admet-2874	66	24	[	[	X
admet-2874	66	25	28	28	NUM
admet-2874	66	26	]	]	PUNCT
admet-2874	66	27	.	.	PUNCT
admet-2874	67	1	apoptotic	apoptotic	ADJ
admet-2874	67	2	bodies	body	NOUN
admet-2874	67	3	derived	derive	VERB
admet-2874	67	4	from	from	ADP
admet-2874	67	5	hepatocytes	hepatocyte	NOUN
admet-2874	67	6	also	also	ADV
admet-2874	67	7	play	play	VERB
admet-2874	67	8	a	a	DET
admet-2874	67	9	role	role	NOUN
admet-2874	67	10	in	in	ADP
admet-2874	67	11	stellate	stellate	ADJ
admet-2874	67	12	cell	cell	NOUN
admet-2874	67	13	activation	activation	NOUN
admet-2874	67	14	,	,	PUNCT
admet-2874	67	15	without	without	ADP
admet-2874	67	16	triggering	trigger	VERB
admet-2874	67	17	an	an	DET
admet-2874	67	18	inflammatory	inflammatory	ADJ
admet-2874	67	19	response	response	NOUN
admet-2874	67	20	,	,	PUNCT
admet-2874	67	21	and	and	CCONJ
admet-2874	67	22	directly	directly	ADV
admet-2874	67	23	promote	promote	VERB
admet-2874	67	24	fibrogenesis	fibrogenesis	NOUN
admet-2874	67	25	[	[	X
admet-2874	67	26	29	29	NUM
admet-2874	67	27	]	]	PUNCT
admet-2874	67	28	.	.	PUNCT
admet-2874	68	1	hepatocyte	hepatocyte	NOUN
admet-2874	68	2	-	-	PUNCT
admet-2874	68	3	expressed	express	VERB
admet-2874	68	4	p450	p450	PROPN
admet-2874	68	5	-	-	SYM
admet-2874	68	6	2e1	2e1	NUM
admet-2874	68	7	further	far	ADV
admet-2874	68	8	contributes	contribute	VERB
admet-2874	68	9	to	to	AUX
admet-2874	68	10	stellate	stellate	ADJ
admet-2874	68	11	cell	cell	NOUN
admet-2874	68	12	activation	activation	NOUN
admet-2874	68	13	by	by	ADP
admet-2874	68	14	generating	generate	VERB
admet-2874	68	15	ros	ros	PROPN
admet-2874	68	16	during	during	ADP
admet-2874	68	17	xenobiotic	xenobiotic	ADJ
admet-2874	68	18	metabolism	metabolism	NOUN
admet-2874	69	1	[	[	X
admet-2874	69	2	30	30	NUM
admet-2874	69	3	]	]	PUNCT
admet-2874	69	4	.	.	PUNCT
admet-2874	70	1	in	in	ADP
admet-2874	70	2	translational	translational	ADJ
admet-2874	70	3	and	and	CCONJ
admet-2874	70	4	post	post	ADJ
admet-2874	70	5	-	-	ADJ
admet-2874	70	6	transcriptional	transcriptional	ADJ
admet-2874	70	7	mechanisms	mechanism	NOUN
admet-2874	70	8	,	,	PUNCT
admet-2874	70	9	including	include	VERB
admet-2874	70	10	mirnas	mirna	NOUN
admet-2874	70	11	and	and	CCONJ
admet-2874	70	12	epigenetic	epigenetic	ADJ
admet-2874	70	13	regulation	regulation	NOUN
admet-2874	70	14	,	,	PUNCT
admet-2874	70	15	stellate	stellate	ADJ
admet-2874	70	16	cell	cell	NOUN
admet-2874	70	17	responses	response	NOUN
admet-2874	70	18	are	be	AUX
admet-2874	70	19	modulated	modulate	VERB
admet-2874	70	20	[	[	PUNCT
admet-2874	70	21	31	31	NUM
admet-2874	70	22	]	]	PUNCT
admet-2874	70	23	.	.	PUNCT
admet-2874	71	1	in	in	ADP
admet-2874	71	2	the	the	DET
admet-2874	71	3	perpetuation	perpetuation	NOUN
admet-2874	71	4	phase	phase	NOUN
admet-2874	71	5	,	,	PUNCT
admet-2874	71	6	hsc	hsc	NOUN
admet-2874	71	7	activation	activation	NOUN
admet-2874	71	8	involves	involve	VERB
admet-2874	71	9	cellular	cellular	ADJ
admet-2874	71	10	processes	process	NOUN
admet-2874	71	11	such	such	ADJ
admet-2874	71	12	as	as	ADP
admet-2874	71	13	proliferation	proliferation	NOUN
admet-2874	71	14	,	,	PUNCT
admet-2874	71	15	fibrogenesis	fibrogenesis	ADJ
admet-2874	71	16	,	,	PUNCT
admet-2874	71	17	chemotaxis	chemotaxis	ADJ
admet-2874	71	18	,	,	PUNCT
admet-2874	71	19	and	and	CCONJ
admet-2874	71	20	matrix	matrix	NOUN
admet-2874	71	21	degradation	degradation	NOUN
admet-2874	71	22	.	.	PUNCT
admet-2874	72	1	upregulation	upregulation	NOUN
admet-2874	72	2	of	of	ADP
admet-2874	72	3	pdgf	pdgf	ADJ
admet-2874	72	4	receptor	receptor	NOUN
admet-2874	72	5	expression	expression	NOUN
admet-2874	72	6	via	via	ADP
admet-2874	72	7	tnf	tnf	PROPN
admet-2874	72	8	-	-	PUNCT
admet-2874	72	9	α	α	NOUN
admet-2874	72	10	enhances	enhance	VERB
admet-2874	72	11	the	the	DET
admet-2874	72	12	fibrogenic	fibrogenic	ADJ
admet-2874	72	13	phenotype	phenotype	NOUN
admet-2874	72	14	of	of	ADP
admet-2874	72	15	stellate	stellate	ADJ
admet-2874	72	16	cells	cell	NOUN
admet-2874	72	17	[	[	X
admet-2874	72	18	32	32	NUM
admet-2874	72	19	]	]	PUNCT
admet-2874	72	20	.	.	PUNCT
admet-2874	73	1	matrix	matrix	NOUN
admet-2874	73	2	metalloproteinases	metalloproteinase	NOUN
admet-2874	73	3	(	(	PUNCT
admet-2874	73	4	mmps	mmp	NOUN
admet-2874	73	5	)	)	PUNCT
admet-2874	73	6	,	,	PUNCT
admet-2874	73	7	such	such	ADJ
admet-2874	73	8	as	as	ADP
admet-2874	73	9	mmp-2	mmp-2	NUM
admet-2874	73	10	and	and	CCONJ
admet-2874	73	11	mmp-9	mmp-9	NUM
admet-2874	73	12	,	,	PUNCT
admet-2874	73	13	play	play	VERB
admet-2874	73	14	dual	dual	ADJ
admet-2874	73	15	roles	role	NOUN
admet-2874	73	16	in	in	ADP
admet-2874	73	17	fibrosis	fibrosis	NOUN
admet-2874	73	18	progression	progression	NOUN
admet-2874	73	19	;	;	PUNCT
admet-2874	73	20	while	while	SCONJ
admet-2874	73	21	they	they	PRON
admet-2874	73	22	regulate	regulate	VERB
admet-2874	73	23	ecm	ecm	NOUN
admet-2874	73	24	turnover	turnover	NOUN
admet-2874	73	25	,	,	PUNCT
admet-2874	73	26	their	their	PRON
admet-2874	73	27	antifibrotic	antifibrotic	ADJ
admet-2874	73	28	expression	expression	NOUN
admet-2874	73	29	declines	decline	VERB
admet-2874	73	30	as	as	SCONJ
admet-2874	73	31	fibrosis	fibrosis	NOUN
admet-2874	73	32	advances	advance	VERB
admet-2874	73	33	[	[	X
admet-2874	73	34	33	33	NUM
admet-2874	73	35	]	]	PUNCT
admet-2874	73	36	.	.	PUNCT
admet-2874	74	1	moreover	moreover	ADV
admet-2874	74	2	,	,	PUNCT
admet-2874	74	3	stellate	stellate	ADJ
admet-2874	74	4	cells	cell	NOUN
admet-2874	74	5	also	also	ADV
admet-2874	74	6	express	express	VERB
admet-2874	74	7	a	a	DET
admet-2874	74	8	variety	variety	NOUN
admet-2874	74	9	of	of	ADP
admet-2874	74	10	chemokine	chemokine	ADJ
admet-2874	74	11	receptors	receptor	NOUN
admet-2874	74	12	that	that	PRON
admet-2874	74	13	are	be	AUX
admet-2874	74	14	important	important	ADJ
admet-2874	74	15	in	in	ADP
admet-2874	74	16	cell	cell	NOUN
admet-2874	74	17	migration	migration	NOUN
admet-2874	74	18	and	and	CCONJ
admet-2874	74	19	subsequent	subsequent	ADJ
admet-2874	74	20	activation	activation	NOUN
admet-2874	74	21	,	,	PUNCT
admet-2874	74	22	including	include	VERB
admet-2874	74	23	cxcr4	cxcr4	NOUN
admet-2874	74	24	and	and	CCONJ
admet-2874	74	25	ccr5	ccr5	NOUN
admet-2874	75	1	[	[	X
admet-2874	75	2	34,35	34,35	NOUN
admet-2874	75	3	]	]	PUNCT
admet-2874	75	4	.	.	PUNCT
admet-2874	76	1	tgf	tgf	PROPN
admet-2874	76	2	-	-	PUNCT
admet-2874	76	3	β1	β1	PROPN
admet-2874	76	4	stimulates	stimulate	VERB
admet-2874	76	5	ecm	ecm	NOUN
admet-2874	76	6	production	production	NOUN
admet-2874	76	7	through	through	ADP
admet-2874	76	8	autocrine	autocrine	NOUN
admet-2874	76	9	and	and	CCONJ
admet-2874	76	10	paracrine	paracrine	NOUN
admet-2874	76	11	pathways	pathway	NOUN
admet-2874	76	12	,	,	PUNCT
admet-2874	76	13	while	while	SCONJ
admet-2874	76	14	connective	connective	ADJ
admet-2874	76	15	tissue	tissue	NOUN
admet-2874	76	16	growth	growth	NOUN
admet-2874	76	17	factor	factor	NOUN
admet-2874	76	18	(	(	PUNCT
admet-2874	76	19	ctgf	ctgf	NOUN
admet-2874	76	20	)	)	PUNCT
admet-2874	76	21	amplifies	amplify	VERB
admet-2874	76	22	profibrotic	profibrotic	ADJ
admet-2874	76	23	signals	signal	NOUN
admet-2874	76	24	via	via	ADP
admet-2874	76	25	a	a	DET
admet-2874	76	26	g	g	ADV
admet-2874	76	27	-	-	PUNCT
admet-2874	76	28	proteincoupled	proteincouple	VERB
admet-2874	76	29	receptor	receptor	NOUN
admet-2874	77	1	[	[	X
admet-2874	77	2	36	36	NUM
admet-2874	77	3	]	]	PUNCT
admet-2874	77	4	.	.	PUNCT
admet-2874	78	1	micro	micro	PROPN
admet-2874	78	2	irnas	irnas	PROPN
admet-2874	78	3	,	,	PUNCT
admet-2874	78	4	especially	especially	ADV
admet-2874	78	5	mir-29b	mir-29b	NUM
admet-2874	78	6	,	,	PUNCT
admet-2874	78	7	play	play	VERB
admet-2874	78	8	a	a	DET
admet-2874	78	9	major	major	ADJ
admet-2874	78	10	function	function	NOUN
admet-2874	78	11	in	in	ADP
admet-2874	78	12	regulating	regulate	VERB
admet-2874	78	13	collagen	collagen	NOUN
admet-2874	78	14	synthesis	synthesis	NOUN
admet-2874	78	15	via	via	ADP
admet-2874	78	16	inhibiting	inhibit	VERB
admet-2874	78	17	tgf	tgf	PROPN
admet-2874	78	18	-	-	PUNCT
admet-2874	78	19	β	β	NOUN
admet-2874	78	20	-	-	ADJ
admet-2874	78	21	induced	induce	VERB
admet-2874	78	22	collagen	collagen	NOUN
admet-2874	78	23	production	production	NOUN
admet-2874	78	24	[	[	X
admet-2874	78	25	37	37	NUM
admet-2874	78	26	]	]	PUNCT
admet-2874	78	27	.	.	PUNCT
admet-2874	79	1	crucially	crucially	ADV
admet-2874	79	2	,	,	PUNCT
admet-2874	79	3	mitochondrial	mitochondrial	ADJ
admet-2874	79	4	ros	ros	PROPN
admet-2874	79	5	and	and	CCONJ
admet-2874	79	6	hif-1α	hif-1α	NOUN
admet-2874	79	7	-	-	PUNCT
admet-2874	79	8	mediated	mediate	VERB
admet-2874	79	9	hypoxia	hypoxia	NOUN
admet-2874	79	10	-	-	PUNCT
admet-2874	79	11	induced	induced	ADJ
admet-2874	79	12	signalling	signal	VERB
admet-2874	79	13	pathways	pathway	NOUN
admet-2874	79	14	,	,	PUNCT
admet-2874	79	15	such	such	ADJ
admet-2874	79	16	as	as	ADP
admet-2874	79	17	erk1/2	erk1/2	PROPN
admet-2874	79	18	and	and	CCONJ
admet-2874	79	19	jnk1/2	jnk1/2	PROPN
admet-2874	79	20	,	,	PUNCT
admet-2874	79	21	further	far	ADV
admet-2874	79	22	promote	promote	VERB
admet-2874	79	23	hsc	hsc	NOUN
admet-2874	79	24	migration	migration	NOUN
admet-2874	79	25	and	and	CCONJ
admet-2874	79	26	activation	activation	NOUN
admet-2874	79	27	,	,	PUNCT
admet-2874	79	28	underscoring	underscore	VERB
admet-2874	79	29	the	the	DET
admet-2874	79	30	intricate	intricate	ADJ
admet-2874	79	31	interactions	interaction	NOUN
admet-2874	79	32	of	of	ADP
admet-2874	79	33	molecular	molecular	ADJ
admet-2874	79	34	pathways	pathway	NOUN
admet-2874	79	35	implicated	implicate	VERB
admet-2874	79	36	in	in	ADP
admet-2874	79	37	liver	liver	NOUN
admet-2874	79	38	fibrosis	fibrosis	NOUN
admet-2874	79	39	[	[	X
admet-2874	79	40	38	38	NUM
admet-2874	79	41	]	]	PUNCT
admet-2874	79	42	.	.	PUNCT
admet-2874	80	1	regulatory	regulatory	ADJ
admet-2874	80	2	t	t	PROPN
admet-2874	80	3	cells	cell	NOUN
admet-2874	80	4	(	(	PUNCT
admet-2874	80	5	tregs	treg	NOUN
admet-2874	80	6	)	)	PUNCT
admet-2874	80	7	mitigate	mitigate	VERB
admet-2874	80	8	hepatic	hepatic	ADJ
admet-2874	80	9	fibrogenesis	fibrogenesis	NOUN
admet-2874	80	10	by	by	ADP
admet-2874	80	11	producing	produce	VERB
admet-2874	80	12	il-10	il-10	PRON
admet-2874	80	13	,	,	PUNCT
admet-2874	80	14	which	which	PRON
admet-2874	80	15	inhibits	inhibit	VERB
admet-2874	80	16	hsc	hsc	NOUN
admet-2874	80	17	activation	activation	NOUN
admet-2874	80	18	and	and	CCONJ
admet-2874	80	19	the	the	DET
admet-2874	80	20	production	production	NOUN
admet-2874	80	21	of	of	ADP
admet-2874	80	22	th17	th17	PROPN
admet-2874	80	23	-	-	PUNCT
admet-2874	80	24	derived	derive	VERB
admet-2874	80	25	il-17	il-17	NOUN
admet-2874	80	26	,	,	PUNCT
admet-2874	80	27	while	while	SCONJ
admet-2874	80	28	also	also	ADV
admet-2874	80	29	limiting	limit	VERB
admet-2874	80	30	kupffer	kupffer	NOUN
admet-2874	80	31	cell	cell	NOUN
admet-2874	80	32	activation	activation	NOUN
admet-2874	80	33	[	[	X
admet-2874	80	34	39	39	NUM
admet-2874	80	35	]	]	PUNCT
admet-2874	80	36	.	.	PUNCT
admet-2874	81	1	although	although	SCONJ
admet-2874	81	2	initially	initially	ADV
admet-2874	81	3	believed	believe	VERB
admet-2874	81	4	to	to	PART
admet-2874	81	5	play	play	VERB
admet-2874	81	6	protective	protective	ADJ
admet-2874	81	7	roles	role	NOUN
admet-2874	81	8	in	in	ADP
admet-2874	81	9	nafld	nafld	ADJ
admet-2874	81	10	,	,	PUNCT
admet-2874	81	11	mucosal	mucosal	NOUN
admet-2874	81	12	-	-	PUNCT
admet-2874	81	13	associated	associate	VERB
admet-2874	81	14	invariant	invariant	PROPN
admet-2874	81	15	t	t	NOUN
admet-2874	81	16	cells	cell	NOUN
admet-2874	81	17	(	(	PUNCT
admet-2874	81	18	mait	mait	ADJ
admet-2874	81	19	)	)	PUNCT
admet-2874	81	20	depletion	depletion	NOUN
admet-2874	81	21	in	in	ADP
admet-2874	81	22	mice	mouse	NOUN
admet-2874	81	23	has	have	AUX
admet-2874	81	24	been	be	AUX
admet-2874	81	25	connected	connect	VERB
admet-2874	81	26	to	to	ADP
admet-2874	81	27	fibrosis	fibrosis	NOUN
admet-2874	81	28	resistance	resistance	NOUN
admet-2874	81	29	.	.	PUNCT
admet-2874	82	1	more	more	ADV
admet-2874	82	2	recently	recently	ADV
admet-2874	82	3	,	,	PUNCT
admet-2874	82	4	it	it	PRON
admet-2874	82	5	has	have	AUX
admet-2874	82	6	been	be	AUX
admet-2874	82	7	demonstrated	demonstrate	VERB
admet-2874	82	8	that	that	SCONJ
admet-2874	82	9	mait	mait	PROPN
admet-2874	82	10	cells	cell	NOUN
admet-2874	82	11	induce	induce	VERB
admet-2874	82	12	fibrosis	fibrosis	NOUN
admet-2874	82	13	by	by	ADP
admet-2874	82	14	stimulating	stimulate	VERB
admet-2874	82	15	hscs	hsc	NOUN
admet-2874	82	16	through	through	ADP
admet-2874	82	17	il-17	il-17	ADV
admet-2874	82	18	and	and	CCONJ
admet-2874	82	19	macrophage	macrophage	ADJ
admet-2874	82	20	pro	pro	ADJ
admet-2874	82	21	-	-	ADJ
admet-2874	82	22	inflammatory	inflammatory	ADJ
admet-2874	82	23	polarization	polarization	NOUN
admet-2874	82	24	[	[	X
admet-2874	82	25	40,41	40,41	NOUN
admet-2874	82	26	]	]	PUNCT
admet-2874	82	27	.	.	PUNCT
admet-2874	83	1	similarly	similarly	ADV
admet-2874	83	2	,	,	PUNCT
admet-2874	83	3	γδ	γδ	ADP
admet-2874	83	4	t	t	NOUN
admet-2874	83	5	cells	cell	NOUN
admet-2874	83	6	,	,	PUNCT
admet-2874	83	7	which	which	PRON
admet-2874	83	8	accumulate	accumulate	VERB
admet-2874	83	9	in	in	ADP
admet-2874	83	10	fibrotic	fibrotic	ADJ
admet-2874	83	11	livers	liver	NOUN
admet-2874	83	12	,	,	PUNCT
admet-2874	83	13	can	can	AUX
admet-2874	83	14	induce	induce	VERB
admet-2874	83	15	hsc	hsc	NOUN
admet-2874	83	16	apoptosis	apoptosis	NOUN
admet-2874	83	17	and	and	CCONJ
admet-2874	83	18	enhance	enhance	VERB
admet-2874	83	19	natural	natural	ADJ
admet-2874	83	20	killer	killer	NOUN
admet-2874	83	21	cellmediated	cellmediate	VERB
admet-2874	83	22	cytotoxicity	cytotoxicity	NOUN
admet-2874	83	23	,	,	PUNCT
admet-2874	83	24	thereby	thereby	ADV
admet-2874	83	25	limiting	limit	VERB
admet-2874	83	26	fibrosis	fibrosis	NOUN
admet-2874	83	27	,	,	PUNCT
admet-2874	83	28	though	though	SCONJ
admet-2874	83	29	they	they	PRON
admet-2874	83	30	also	also	ADV
admet-2874	83	31	contribute	contribute	VERB
admet-2874	83	32	to	to	ADP
admet-2874	83	33	il-17	il-17	PART
admet-2874	83	34	production	production	NOUN
admet-2874	83	35	,	,	PUNCT
admet-2874	83	36	supporting	support	VERB
admet-2874	83	37	fibrogenesis	fibrogenesis	NOUN
admet-2874	83	38	[	[	X
admet-2874	83	39	42,43	42,43	NOUN
admet-2874	83	40	]	]	PUNCT
admet-2874	83	41	.	.	PUNCT
admet-2874	84	1	innate	innate	ADJ
admet-2874	84	2	lymphoid	lymphoid	ADJ
admet-2874	84	3	cells	cell	NOUN
admet-2874	84	4	(	(	PUNCT
admet-2874	84	5	ilcs	ilcs	NOUN
admet-2874	84	6	)	)	PUNCT
admet-2874	84	7	,	,	PUNCT
admet-2874	84	8	particularly	particularly	ADV
admet-2874	84	9	nk	nk	PROPN
admet-2874	84	10	cells	cell	NOUN
admet-2874	84	11	,	,	PUNCT
admet-2874	84	12	play	play	VERB
admet-2874	84	13	a	a	DET
admet-2874	84	14	pivotal	pivotal	ADJ
admet-2874	84	15	role	role	NOUN
admet-2874	84	16	in	in	ADP
admet-2874	84	17	liver	liver	NOUN
admet-2874	84	18	fibrosis	fibrosis	NOUN
admet-2874	84	19	,	,	PUNCT
admet-2874	84	20	with	with	ADP
admet-2874	84	21	nk	nk	PROPN
admet-2874	84	22	cells	cell	NOUN
admet-2874	84	23	exhibiting	exhibit	VERB
admet-2874	84	24	antifibrotic	antifibrotic	ADJ
admet-2874	84	25	effects	effect	NOUN
admet-2874	84	26	by	by	ADP
admet-2874	84	27	killing	kill	VERB
admet-2874	84	28	activated	activate	VERB
admet-2874	84	29	hscs	hsc	NOUN
admet-2874	84	30	and	and	CCONJ
admet-2874	84	31	releasing	release	VERB
admet-2874	84	32	ifnγ	ifnγ	NOUN
admet-2874	84	33	,	,	PUNCT
admet-2874	84	34	offering	offer	VERB
admet-2874	84	35	a	a	DET
admet-2874	84	36	potential	potential	ADJ
admet-2874	84	37	therapeutic	therapeutic	ADJ
admet-2874	84	38	strategy	strategy	NOUN
admet-2874	84	39	by	by	ADP
admet-2874	84	40	boosting	boost	VERB
admet-2874	84	41	their	their	PRON
admet-2874	84	42	activity	activity	NOUN
admet-2874	84	43	[	[	X
admet-2874	84	44	44,45]the	44,45]the	DET
admet-2874	84	45	intricate	intricate	ADJ
admet-2874	84	46	relationships	relationship	NOUN
admet-2874	84	47	among	among	ADP
admet-2874	84	48	these	these	DET
admet-2874	84	49	many	many	ADJ
admet-2874	84	50	immune	immune	ADJ
admet-2874	84	51	cell	cell	NOUN
admet-2874	84	52	types	type	NOUN
admet-2874	84	53	highlight	highlight	VERB
admet-2874	84	54	the	the	DET
admet-2874	84	55	complexity	complexity	NOUN
admet-2874	84	56	of	of	ADP
admet-2874	84	57	liver	liver	NOUN
admet-2874	84	58	fibrosis	fibrosis	NOUN
admet-2874	84	59	,	,	PUNCT
admet-2874	84	60	where	where	SCONJ
admet-2874	84	61	the	the	DET
admet-2874	84	62	resolution	resolution	NOUN
admet-2874	84	63	or	or	CCONJ
admet-2874	84	64	development	development	NOUN
admet-2874	84	65	of	of	ADP
admet-2874	84	66	the	the	DET
admet-2874	84	67	illness	illness	NOUN
admet-2874	84	68	is	be	AUX
admet-2874	84	69	determined	determine	VERB
admet-2874	84	70	by	by	ADP
admet-2874	84	71	the	the	DET
admet-2874	84	72	balance	balance	NOUN
admet-2874	84	73	between	between	ADP
admet-2874	84	74	profibrotic	profibrotic	ADJ
admet-2874	84	75	and	and	CCONJ
admet-2874	84	76	antifibrotic	antifibrotic	ADJ
admet-2874	84	77	signalling	signal	VERB
admet-2874	84	78	pathways	pathway	NOUN
admet-2874	84	79	(	(	PUNCT
admet-2874	84	80	see	see	VERB
admet-2874	84	81	figure	figure	NOUN
admet-2874	84	82	1	1	NUM
admet-2874	84	83	)	)	PUNCT
admet-2874	84	84	.	.	PUNCT
admet-2874	85	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	85	2	a.	a.	NOUN
admet-2874	85	3	singh	singh	PROPN
admet-2874	85	4	et	et	PROPN
admet-2874	85	5	al	al	PROPN
admet-2874	85	6	.	.	PROPN
admet-2874	85	7	admet	admet	PROPN
admet-2874	85	8	&	&	CCONJ
admet-2874	85	9	dmpk	dmpk	PROPN
admet-2874	85	10	13(4	13(4	NUM
admet-2874	85	11	)	)	PUNCT
admet-2874	85	12	(	(	PUNCT
admet-2874	85	13	2025	2025	NUM
admet-2874	85	14	)	)	PUNCT
admet-2874	85	15	2874	2874	NUM
admet-2874	85	16	4	4	NUM
admet-2874	85	17	figure	figure	NOUN
admet-2874	85	18	1	1	NUM
admet-2874	85	19	.	.	PUNCT
admet-2874	85	20	pathophysiology	pathophysiology	NOUN
admet-2874	85	21	of	of	ADP
admet-2874	85	22	hepatic	hepatic	ADJ
admet-2874	85	23	stellate	stellate	ADJ
admet-2874	85	24	cells	cell	NOUN
admet-2874	85	25	.	.	PUNCT
admet-2874	86	1	several	several	ADJ
admet-2874	86	2	dramatic	dramatic	ADJ
admet-2874	86	3	changes	change	NOUN
admet-2874	86	4	occurred	occur	VERB
admet-2874	86	5	during	during	ADP
admet-2874	86	6	the	the	DET
admet-2874	86	7	development	development	NOUN
admet-2874	86	8	of	of	ADP
admet-2874	86	9	liver	liver	NOUN
admet-2874	86	10	fibrosis	fibrosis	NOUN
admet-2874	86	11	at	at	ADP
admet-2874	86	12	cellular	cellular	ADJ
admet-2874	86	13	level	level	NOUN
admet-2874	86	14	.	.	PUNCT
admet-2874	87	1	liver	liver	NOUN
admet-2874	87	2	fibrosis	fibrosis	NOUN
admet-2874	87	3	is	be	AUX
admet-2874	87	4	incurred	incur	VERB
admet-2874	87	5	by	by	ADP
admet-2874	87	6	several	several	ADJ
admet-2874	87	7	factors	factor	NOUN
admet-2874	87	8	,	,	PUNCT
admet-2874	87	9	including	include	VERB
admet-2874	87	10	drugs	drug	NOUN
admet-2874	87	11	,	,	PUNCT
admet-2874	87	12	schistosomes	schistosome	NOUN
admet-2874	87	13	,	,	PUNCT
admet-2874	87	14	sibo	sibo	NOUN
admet-2874	87	15	,	,	PUNCT
admet-2874	87	16	hcv	hcv	PROPN
admet-2874	87	17	&	&	CCONJ
admet-2874	87	18	hbv	hbv	PROPN
admet-2874	87	19	,	,	PUNCT
admet-2874	87	20	and	and	CCONJ
admet-2874	87	21	alcohol	alcohol	NOUN
admet-2874	87	22	followed	follow	VERB
admet-2874	87	23	by	by	ADP
admet-2874	87	24	hsc	hsc	NOUN
admet-2874	87	25	activation	activation	NOUN
admet-2874	87	26	.	.	PUNCT
admet-2874	88	1	regular	regular	ADJ
admet-2874	88	2	injury	injury	NOUN
admet-2874	88	3	fosters	foster	VERB
admet-2874	88	4	a	a	DET
admet-2874	88	5	chronic	chronic	ADJ
admet-2874	88	6	liver	liver	NOUN
admet-2874	88	7	disease	disease	NOUN
admet-2874	88	8	.	.	PUNCT
admet-2874	89	1	in	in	ADP
admet-2874	89	2	activated	activate	VERB
admet-2874	89	3	hsc	hsc	NOUN
admet-2874	89	4	cells	cell	NOUN
admet-2874	89	5	,	,	PUNCT
admet-2874	89	6	collagen	collagen	NOUN
admet-2874	89	7	and	and	CCONJ
admet-2874	89	8	extracellular	extracellular	ADJ
admet-2874	89	9	matrix	matrix	NOUN
admet-2874	89	10	accumulation	accumulation	NOUN
admet-2874	89	11	,	,	PUNCT
admet-2874	89	12	vitamin	vitamin	NOUN
admet-2874	89	13	a	a	PRON
admet-2874	89	14	is	be	AUX
admet-2874	89	15	lost	lose	VERB
admet-2874	89	16	,	,	PUNCT
admet-2874	89	17	and	and	CCONJ
admet-2874	89	18	oxidative	oxidative	ADJ
admet-2874	89	19	stress	stress	NOUN
admet-2874	89	20	occurs	occur	VERB
admet-2874	89	21	.	.	PUNCT
admet-2874	90	1	overall	overall	ADV
admet-2874	90	2	,	,	PUNCT
admet-2874	90	3	cells	cell	NOUN
admet-2874	90	4	including	include	VERB
admet-2874	90	5	macrophages	macrophage	NOUN
admet-2874	90	6	,	,	PUNCT
admet-2874	90	7	kupffer	kupffer	NOUN
admet-2874	90	8	cells	cell	NOUN
admet-2874	90	9	,	,	PUNCT
admet-2874	90	10	platelets	platelet	NOUN
admet-2874	90	11	,	,	PUNCT
admet-2874	90	12	b	b	NOUN
admet-2874	90	13	cells	cell	NOUN
admet-2874	90	14	,	,	PUNCT
admet-2874	90	15	and	and	CCONJ
admet-2874	90	16	natural	natural	ADJ
admet-2874	90	17	killer	killer	NOUN
admet-2874	90	18	cells	cell	NOUN
admet-2874	90	19	are	be	AUX
admet-2874	90	20	involved	involve	VERB
admet-2874	90	21	in	in	ADP
admet-2874	90	22	the	the	DET
admet-2874	90	23	activation	activation	NOUN
admet-2874	90	24	of	of	ADP
admet-2874	90	25	hsc	hsc	NOUN
admet-2874	90	26	the	the	DET
admet-2874	90	27	rspo3	rspo3	NOUN
admet-2874	90	28	-	-	PUNCT
admet-2874	90	29	lgr4/5	lgr4/5	NOUN
admet-2874	90	30	axis	axis	NOUN
admet-2874	90	31	in	in	ADP
admet-2874	90	32	quiescent	quiescent	ADJ
admet-2874	90	33	hepatic	hepatic	ADJ
admet-2874	90	34	stellate	stellate	ADJ
admet-2874	90	35	cells	cell	NOUN
admet-2874	90	36	recently	recently	ADV
admet-2874	90	37	,	,	PUNCT
admet-2874	90	38	sugimoto	sugimoto	PROPN
admet-2874	90	39	et	et	PROPN
admet-2874	90	40	.	.	PUNCT
admet-2874	91	1	al	al	PROPN
admet-2874	91	2	.	.	PUNCT
admet-2874	92	1	[	[	X
admet-2874	92	2	46	46	NUM
admet-2874	92	3	]	]	PUNCT
admet-2874	92	4	demonstrated	demonstrate	VERB
admet-2874	92	5	that	that	SCONJ
admet-2874	92	6	r	r	NOUN
admet-2874	92	7	-	-	PUNCT
admet-2874	92	8	spondin	spondin	NOUN
admet-2874	92	9	3	3	NUM
admet-2874	92	10	(	(	PUNCT
admet-2874	92	11	rspo3	rspo3	NOUN
admet-2874	92	12	)	)	PUNCT
admet-2874	92	13	,	,	PUNCT
admet-2874	92	14	secreted	secrete	VERB
admet-2874	92	15	by	by	ADP
admet-2874	92	16	quiescent	quiescent	ADJ
admet-2874	92	17	hscs	hsc	NOUN
admet-2874	92	18	,	,	PUNCT
admet-2874	92	19	plays	play	VERB
admet-2874	92	20	a	a	DET
admet-2874	92	21	crucial	crucial	ADJ
admet-2874	92	22	role	role	NOUN
admet-2874	92	23	in	in	ADP
admet-2874	92	24	supporting	support	VERB
admet-2874	92	25	hepatocyte	hepatocyte	NOUN
admet-2874	92	26	metabolism	metabolism	NOUN
admet-2874	92	27	,	,	PUNCT
admet-2874	92	28	regeneration	regeneration	NOUN
admet-2874	92	29	,	,	PUNCT
admet-2874	92	30	and	and	CCONJ
admet-2874	92	31	survival	survival	NOUN
admet-2874	92	32	.	.	PUNCT
admet-2874	93	1	these	these	DET
admet-2874	93	2	findings	finding	NOUN
admet-2874	93	3	are	be	AUX
admet-2874	93	4	contrary	contrary	ADJ
admet-2874	93	5	to	to	ADP
admet-2874	93	6	the	the	DET
admet-2874	93	7	traditional	traditional	ADJ
admet-2874	93	8	view	view	NOUN
admet-2874	93	9	of	of	ADP
admet-2874	93	10	hscs	hsc	NOUN
admet-2874	93	11	functioning	function	VERB
admet-2874	93	12	solely	solely	ADV
admet-2874	93	13	as	as	ADP
admet-2874	93	14	fibrogenic	fibrogenic	ADJ
admet-2874	93	15	drivers	driver	NOUN
admet-2874	93	16	in	in	ADP
admet-2874	93	17	chronic	chronic	ADJ
admet-2874	93	18	liver	liver	NOUN
admet-2874	93	19	disease	disease	NOUN
admet-2874	93	20	(	(	PUNCT
admet-2874	93	21	cld	cld	NOUN
admet-2874	93	22	)	)	PUNCT
admet-2874	93	23	.	.	PUNCT
admet-2874	94	1	the	the	DET
admet-2874	94	2	study	study	NOUN
admet-2874	94	3	demonstrated	demonstrate	VERB
admet-2874	94	4	that	that	SCONJ
admet-2874	94	5	as	as	SCONJ
admet-2874	94	6	cld	cld	NOUN
admet-2874	94	7	progresses	progress	VERB
admet-2874	94	8	,	,	PUNCT
admet-2874	94	9	rspo3	rspo3	NOUN
admet-2874	94	10	expression	expression	NOUN
admet-2874	94	11	declines	decline	VERB
admet-2874	94	12	,	,	PUNCT
admet-2874	94	13	leading	lead	VERB
admet-2874	94	14	to	to	ADP
admet-2874	94	15	worsened	worsen	VERB
admet-2874	94	16	liver	liver	NOUN
admet-2874	94	17	function	function	NOUN
admet-2874	94	18	and	and	CCONJ
admet-2874	94	19	fibrosis	fibrosis	NOUN
admet-2874	94	20	.	.	PUNCT
admet-2874	95	1	the	the	DET
admet-2874	95	2	rspo3	rspo3	PROPN
admet-2874	95	3	-	-	PUNCT
admet-2874	95	4	lgr4/5	lgr4/5	NOUN
admet-2874	95	5	-	-	PUNCT
admet-2874	95	6	β	β	NOUN
admet-2874	95	7	-	-	ADJ
admet-2874	95	8	catenin	catenin	ADJ
admet-2874	95	9	pathway	pathway	NOUN
admet-2874	95	10	was	be	AUX
admet-2874	95	11	demonstrated	demonstrate	VERB
admet-2874	95	12	as	as	ADP
admet-2874	95	13	a	a	DET
admet-2874	95	14	crucial	crucial	ADJ
admet-2874	95	15	communication	communication	NOUN
admet-2874	95	16	axis	axis	NOUN
admet-2874	95	17	between	between	ADP
admet-2874	95	18	hscs	hsc	NOUN
admet-2874	95	19	,	,	PUNCT
admet-2874	95	20	hepatocytes	hepatocyte	NOUN
admet-2874	95	21	,	,	PUNCT
admet-2874	95	22	and	and	CCONJ
admet-2874	95	23	endothelial	endothelial	ADJ
admet-2874	95	24	cells	cell	NOUN
admet-2874	95	25	,	,	PUNCT
admet-2874	95	26	coordinating	coordinate	VERB
admet-2874	95	27	liver	liver	NOUN
admet-2874	95	28	zonation	zonation	NOUN
admet-2874	95	29	and	and	CCONJ
admet-2874	95	30	function	function	NOUN
admet-2874	95	31	.	.	PUNCT
admet-2874	96	1	therapeutically	therapeutically	ADV
admet-2874	96	2	,	,	PUNCT
admet-2874	96	3	restoring	restore	VERB
admet-2874	96	4	rspo3	rspo3	NOUN
admet-2874	96	5	or	or	CCONJ
admet-2874	96	6	reverting	revert	VERB
admet-2874	96	7	hscs	hsc	NOUN
admet-2874	96	8	to	to	ADP
admet-2874	96	9	a	a	DET
admet-2874	96	10	quiescent	quiescent	ADJ
admet-2874	96	11	state	state	NOUN
admet-2874	96	12	may	may	AUX
admet-2874	96	13	simultaneously	simultaneously	ADV
admet-2874	96	14	suppress	suppress	VERB
admet-2874	96	15	fibrosis	fibrosis	NOUN
admet-2874	96	16	and	and	CCONJ
admet-2874	96	17	restore	restore	VERB
admet-2874	96	18	liver	liver	NOUN
admet-2874	96	19	function	function	NOUN
admet-2874	96	20	,	,	PUNCT
admet-2874	96	21	offering	offer	VERB
admet-2874	96	22	a	a	DET
admet-2874	96	23	promising	promising	ADJ
admet-2874	96	24	strategy	strategy	NOUN
admet-2874	96	25	for	for	ADP
admet-2874	96	26	treating	treat	VERB
admet-2874	96	27	diseases	disease	NOUN
admet-2874	96	28	like	like	ADP
admet-2874	96	29	masld	masld	NOUN
admet-2874	96	30	and	and	CCONJ
admet-2874	96	31	ald	ald	NOUN
admet-2874	97	1	[	[	X
admet-2874	97	2	46	46	NUM
admet-2874	97	3	]	]	PUNCT
admet-2874	97	4	.	.	PUNCT
admet-2874	98	1	single	single	ADJ
admet-2874	98	2	-	-	PUNCT
admet-2874	98	3	cell	cell	NOUN
admet-2874	98	4	rna	rna	NOUN
admet-2874	98	5	sequencing	sequencing	NOUN
admet-2874	98	6	of	of	ADP
admet-2874	98	7	hepatic	hepatic	ADJ
admet-2874	98	8	stellate	stellate	ADJ
admet-2874	98	9	cells	cell	NOUN
admet-2874	98	10	in	in	ADP
admet-2874	98	11	understanding	understand	VERB
admet-2874	98	12	liver	liver	NOUN
admet-2874	98	13	fibrosis	fibrosis	NOUN
admet-2874	98	14	a	a	DET
admet-2874	98	15	very	very	ADV
admet-2874	98	16	recently	recently	ADV
admet-2874	98	17	reported	report	VERB
admet-2874	98	18	study	study	NOUN
admet-2874	98	19	[	[	X
admet-2874	98	20	47	47	NUM
admet-2874	98	21	]	]	PUNCT
admet-2874	98	22	has	have	AUX
admet-2874	98	23	successfully	successfully	ADV
admet-2874	98	24	presented	present	VERB
admet-2874	98	25	the	the	DET
admet-2874	98	26	first	first	ADJ
admet-2874	98	27	single	single	ADJ
admet-2874	98	28	-	-	PUNCT
admet-2874	98	29	cell	cell	NOUN
admet-2874	98	30	atlas	atla	NOUN
admet-2874	98	31	of	of	ADP
admet-2874	98	32	hscs	hsc	NOUN
admet-2874	98	33	across	across	ADP
admet-2874	98	34	seven	seven	NUM
admet-2874	98	35	liver	liver	NOUN
admet-2874	98	36	injury	injury	NOUN
admet-2874	98	37	models	model	NOUN
admet-2874	98	38	in	in	ADP
admet-2874	98	39	mice	mouse	NOUN
admet-2874	98	40	(	(	PUNCT
admet-2874	98	41	using	use	VERB
admet-2874	98	42	10	10	NUM
admet-2874	98	43	experimental	experimental	ADJ
admet-2874	98	44	single	single	ADJ
admet-2874	98	45	-	-	PUNCT
admet-2874	98	46	cell	cell	NOUN
admet-2874	98	47	sequencing	sequence	VERB
admet-2874	98	48	data	datum	NOUN
admet-2874	98	49	)	)	PUNCT
admet-2874	98	50	,	,	PUNCT
admet-2874	98	51	revealing	reveal	VERB
admet-2874	98	52	a	a	DET
admet-2874	98	53	conserved	conserve	VERB
admet-2874	98	54	hsc	hsc	NOUN
admet-2874	98	55	activation	activation	NOUN
admet-2874	98	56	trajectory	trajectory	NOUN
admet-2874	98	57	that	that	PRON
admet-2874	98	58	is	be	AUX
admet-2874	98	59	also	also	ADV
admet-2874	98	60	preserved	preserve	VERB
admet-2874	98	61	in	in	ADP
admet-2874	98	62	human	human	ADJ
admet-2874	98	63	livers	liver	NOUN
admet-2874	98	64	.	.	PUNCT
admet-2874	99	1	the	the	DET
admet-2874	99	2	group	group	NOUN
admet-2874	99	3	identified	identify	VERB
admet-2874	99	4	three	three	NUM
admet-2874	99	5	distinct	distinct	ADJ
admet-2874	99	6	hsc	hsc	NOUN
admet-2874	99	7	subtypes	subtype	NOUN
admet-2874	99	8	—	—	PUNCT
admet-2874	99	9	quiescent	quiescent	ADJ
admet-2874	99	10	(	(	PUNCT
admet-2874	99	11	qhscs	qhscs	NOUN
admet-2874	99	12	)	)	PUNCT
admet-2874	99	13	,	,	PUNCT
admet-2874	99	14	initiatory	initiatory	ADJ
admet-2874	99	15	,	,	PUNCT
admet-2874	99	16	and	and	CCONJ
admet-2874	99	17	myofibroblasts	myofibroblast	NOUN
admet-2874	99	18	—	—	PUNCT
admet-2874	99	19	across	across	ADP
admet-2874	99	20	all	all	DET
admet-2874	99	21	injury	injury	NOUN
admet-2874	99	22	types	type	NOUN
admet-2874	99	23	,	,	PUNCT
admet-2874	99	24	suggesting	suggest	VERB
admet-2874	99	25	a	a	DET
admet-2874	99	26	universal	universal	ADJ
admet-2874	99	27	activation	activation	NOUN
admet-2874	99	28	mechanism	mechanism	NOUN
admet-2874	99	29	for	for	ADP
admet-2874	99	30	liver	liver	NOUN
admet-2874	99	31	fibrosis	fibrosis	NOUN
admet-2874	99	32	.	.	PUNCT
admet-2874	100	1	the	the	DET
admet-2874	100	2	outcome	outcome	NOUN
admet-2874	100	3	of	of	ADP
admet-2874	100	4	the	the	DET
admet-2874	100	5	reported	report	VERB
admet-2874	100	6	study	study	NOUN
admet-2874	100	7	demonstrated	demonstrate	VERB
admet-2874	100	8	key	key	ADJ
admet-2874	100	9	transcription	transcription	NOUN
admet-2874	100	10	factors	factor	NOUN
admet-2874	100	11	(	(	PUNCT
admet-2874	100	12	rxra	rxra	NOUN
admet-2874	100	13	,	,	PUNCT
admet-2874	100	14	foxf1	foxf1	NOUN
admet-2874	100	15	,	,	PUNCT
admet-2874	100	16	nr1h4	nr1h4	PROPN
admet-2874	100	17	for	for	ADP
admet-2874	100	18	qhscs	qhsc	NOUN
admet-2874	100	19	;	;	PUNCT
admet-2874	100	20	fosl1	fosl1	NOUN
admet-2874	100	21	,	,	PUNCT
admet-2874	100	22	egr3	egr3	NOUN
admet-2874	100	23	,	,	PUNCT
admet-2874	100	24	nfkb2	nfkb2	NOUN
admet-2874	100	25	for	for	ADP
admet-2874	100	26	initiatory	initiatory	ADJ
admet-2874	100	27	hscs	hsc	NOUN
admet-2874	100	28	;	;	PUNCT
admet-2874	100	29	and	and	CCONJ
admet-2874	100	30	wt1	wt1	NOUN
admet-2874	100	31	,	,	PUNCT
admet-2874	100	32	prrx1	prrx1	PROPN
admet-2874	100	33	,	,	PUNCT
admet-2874	100	34	mef2c	mef2c	NOUN
admet-2874	100	35	for	for	ADP
admet-2874	100	36	myofibroblasts	myofibroblast	NOUN
admet-2874	100	37	)	)	PUNCT
admet-2874	100	38	and	and	CCONJ
admet-2874	100	39	ligands	ligand	NOUN
admet-2874	100	40	(	(	PUNCT
admet-2874	100	41	tgf	tgf	PROPN
admet-2874	100	42	-	-	PUNCT
admet-2874	100	43	β	β	PROPN
admet-2874	100	44	,	,	PUNCT
admet-2874	100	45	egf	egf	PROPN
admet-2874	100	46	,	,	PUNCT
admet-2874	100	47	spp1	spp1	PROPN
admet-2874	100	48	,	,	PUNCT
admet-2874	100	49	agt	agt	PROPN
admet-2874	100	50	,	,	PUNCT
admet-2874	100	51	and	and	CCONJ
admet-2874	100	52	parathyroid	parathyroid	ADJ
admet-2874	100	53	hormone	hormone	NOUN
admet-2874	100	54	)	)	PUNCT
admet-2874	100	55	functioning	function	VERB
admet-2874	100	56	as	as	ADP
admet-2874	100	57	conserved	conserved	ADJ
admet-2874	100	58	drivers	driver	NOUN
admet-2874	100	59	of	of	ADP
admet-2874	100	60	hsc	hsc	NOUN
admet-2874	100	61	activation	activation	NOUN
admet-2874	100	62	.	.	PUNCT
admet-2874	101	1	the	the	DET
admet-2874	101	2	authors	author	NOUN
admet-2874	101	3	successfully	successfully	ADV
admet-2874	101	4	identified	identify	VERB
admet-2874	101	5	[	[	PUNCT
admet-2874	101	6	47	47	NUM
admet-2874	101	7	]	]	PUNCT
admet-2874	101	8	and	and	CCONJ
admet-2874	101	9	reported	report	VERB
admet-2874	101	10	colec10	colec10	NOUN
admet-2874	101	11	as	as	ADP
admet-2874	101	12	a	a	DET
admet-2874	101	13	highly	highly	ADV
admet-2874	101	14	specific	specific	ADJ
admet-2874	101	15	hsc	hsc	NOUN
admet-2874	101	16	marker	marker	NOUN
admet-2874	101	17	and	and	CCONJ
admet-2874	101	18	potential	potential	ADJ
admet-2874	101	19	biomarker	biomarker	NOUN
admet-2874	101	20	for	for	ADP
admet-2874	101	21	liver	liver	NOUN
admet-2874	101	22	fibrosis	fibrosis	NOUN
admet-2874	101	23	,	,	PUNCT
admet-2874	101	24	outperforming	outperform	VERB
admet-2874	101	25	traditional	traditional	ADJ
admet-2874	101	26	markers	marker	NOUN
admet-2874	101	27	such	such	ADJ
admet-2874	101	28	as	as	ADP
admet-2874	101	29	fib4	fib4	NOUN
admet-2874	101	30	and	and	CCONJ
admet-2874	101	31	apri	apri	PROPN
admet-2874	101	32	.	.	PUNCT
admet-2874	102	1	this	this	DET
admet-2874	102	2	report	report	NOUN
admet-2874	102	3	has	have	AUX
admet-2874	102	4	paved	pave	VERB
admet-2874	102	5	the	the	DET
admet-2874	102	6	way	way	NOUN
admet-2874	102	7	further	far	ADV
admet-2874	102	8	for	for	ADP
admet-2874	102	9	the	the	DET
admet-2874	102	10	potential	potential	NOUN
admet-2874	102	11	for	for	ADP
admet-2874	102	12	broad	broad	ADJ
admet-2874	102	13	application	application	NOUN
admet-2874	102	14	of	of	ADP
admet-2874	102	15	anti	anti	ADJ
admet-2874	102	16	-	-	ADJ
admet-2874	102	17	fibrotic	fibrotic	ADJ
admet-2874	102	18	therapies	therapy	NOUN
admet-2874	102	19	targeting	target	VERB
admet-2874	102	20	conserved	conserve	VERB
admet-2874	102	21	tfs	tfs	NOUN
admet-2874	102	22	or	or	CCONJ
admet-2874	102	23	ligands	ligand	NOUN
admet-2874	102	24	and	and	CCONJ
admet-2874	102	25	markers	marker	NOUN
admet-2874	102	26	for	for	ADP
admet-2874	102	27	their	their	PRON
admet-2874	102	28	potential	potential	ADJ
admet-2874	102	29	role	role	NOUN
admet-2874	102	30	in	in	ADP
admet-2874	102	31	preclinical	preclinical	ADJ
admet-2874	102	32	drug	drug	NOUN
admet-2874	102	33	discovery	discovery	NOUN
admet-2874	102	34	for	for	ADP
admet-2874	102	35	liver	liver	NOUN
admet-2874	102	36	-	-	PUNCT
admet-2874	102	37	related	relate	VERB
admet-2874	102	38	injuries	injury	NOUN
admet-2874	102	39	[	[	X
admet-2874	102	40	47	47	NUM
admet-2874	102	41	]	]	PUNCT
admet-2874	102	42	.	.	PUNCT
admet-2874	103	1	cd47yap	cd47yap	PROPN
admet-2874	103	2	/	/	SYM
admet-2874	103	3	tead4	tead4	NOUN
admet-2874	103	4	pathway	pathway	NOUN
admet-2874	103	5	in	in	ADP
admet-2874	103	6	hepatic	hepatic	ADJ
admet-2874	103	7	stellate	stellate	ADJ
admet-2874	103	8	cells	cell	NOUN
admet-2874	103	9	activation	activation	NOUN
admet-2874	103	10	there	there	PRON
admet-2874	103	11	are	be	VERB
admet-2874	103	12	additional	additional	ADJ
admet-2874	103	13	novel	novel	NOUN
admet-2874	103	14	signalling	signal	VERB
admet-2874	103	15	cascades	cascade	NOUN
admet-2874	103	16	involved	involve	VERB
admet-2874	103	17	in	in	ADP
admet-2874	103	18	hsc	hsc	NOUN
admet-2874	103	19	activation	activation	NOUN
admet-2874	103	20	,	,	PUNCT
admet-2874	103	21	one	one	NUM
admet-2874	103	22	of	of	ADP
admet-2874	103	23	which	which	PRON
admet-2874	103	24	is	be	AUX
admet-2874	103	25	cd47	cd47	PROPN
admet-2874	103	26	,	,	PUNCT
admet-2874	103	27	a	a	DET
admet-2874	103	28	yap	yap	NOUN
admet-2874	103	29	target	target	NOUN
admet-2874	103	30	gene	gene	NOUN
admet-2874	103	31	and	and	CCONJ
admet-2874	103	32	transcriptional	transcriptional	ADJ
admet-2874	103	33	factor	factor	NOUN
admet-2874	103	34	that	that	PRON
admet-2874	103	35	plays	play	VERB
admet-2874	103	36	a	a	DET
admet-2874	103	37	role	role	NOUN
admet-2874	103	38	in	in	ADP
admet-2874	103	39	cell	cell	NOUN
admet-2874	103	40	proliferation	proliferation	NOUN
admet-2874	103	41	,	,	PUNCT
admet-2874	103	42	development	development	NOUN
admet-2874	103	43	,	,	PUNCT
admet-2874	103	44	and	and	CCONJ
admet-2874	103	45	survival	survival	NOUN
admet-2874	103	46	.	.	PUNCT
admet-2874	104	1	cd47	cd47	PROPN
admet-2874	104	2	is	be	AUX
admet-2874	104	3	also	also	ADV
admet-2874	104	4	known	know	VERB
admet-2874	104	5	to	to	PART
admet-2874	104	6	prevent	prevent	VERB
admet-2874	104	7	phagocytosis	phagocytosis	NOUN
admet-2874	104	8	by	by	ADP
admet-2874	104	9	inhibiting	inhibit	VERB
admet-2874	104	10	macrophage	macrophage	ADJ
admet-2874	104	11	activity	activity	NOUN
admet-2874	104	12	,	,	PUNCT
admet-2874	104	13	and	and	CCONJ
admet-2874	104	14	tead4	tead4	NOUN
admet-2874	104	15	has	have	VERB
admet-2874	104	16	a	a	DET
admet-2874	104	17	developmental	developmental	ADJ
admet-2874	104	18	role	role	NOUN
admet-2874	104	19	.	.	PUNCT
admet-2874	105	1	here	here	ADV
admet-2874	105	2	,	,	PUNCT
admet-2874	105	3	admet	admet	PROPN
admet-2874	105	4	&	&	CCONJ
admet-2874	105	5	dmpk	dmpk	PROPN
admet-2874	105	6	13(4	13(4	NUM
admet-2874	105	7	)	)	PUNCT
admet-2874	105	8	(	(	PUNCT
admet-2874	105	9	2025	2025	NUM
admet-2874	105	10	)	)	PUNCT
admet-2874	105	11	2874	2874	NUM
admet-2874	105	12	hscs	hsc	NOUN
admet-2874	105	13	in	in	ADP
admet-2874	105	14	liver	liver	NOUN
admet-2874	105	15	fibrosis	fibrosis	NOUN
admet-2874	105	16	:	:	PUNCT
admet-2874	105	17	therapeutic	therapeutic	ADJ
admet-2874	105	18	advances	advance	NOUN
admet-2874	105	19	doi	doi	NOUN
admet-2874	105	20	:	:	PUNCT
admet-2874	105	21	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	105	22	5	5	NUM
admet-2874	105	23	yap	yap	NOUN
admet-2874	105	24	and	and	CCONJ
admet-2874	105	25	tead4	tead4	NOUN
admet-2874	105	26	function	function	NOUN
admet-2874	105	27	in	in	ADP
admet-2874	105	28	a	a	DET
admet-2874	105	29	complementary	complementary	ADJ
admet-2874	105	30	manner	manner	NOUN
admet-2874	105	31	to	to	ADP
admet-2874	105	32	each	each	DET
admet-2874	105	33	other	other	ADJ
admet-2874	105	34	in	in	ADP
admet-2874	105	35	the	the	DET
admet-2874	105	36	induction	induction	NOUN
admet-2874	105	37	of	of	ADP
admet-2874	105	38	cd47	cd47	PROPN
admet-2874	105	39	transcriptional	transcriptional	ADJ
admet-2874	105	40	activation	activation	NOUN
admet-2874	105	41	.	.	PUNCT
admet-2874	106	1	this	this	DET
admet-2874	106	2	pathway	pathway	NOUN
admet-2874	106	3	contributes	contribute	VERB
admet-2874	106	4	to	to	ADP
admet-2874	106	5	the	the	DET
admet-2874	106	6	activation	activation	NOUN
admet-2874	106	7	of	of	ADP
admet-2874	106	8	hsc	hsc	PROPN
admet-2874	106	9	,	,	PUNCT
admet-2874	106	10	and	and	CCONJ
admet-2874	106	11	hence	hence	ADV
admet-2874	106	12	,	,	PUNCT
admet-2874	106	13	liver	liver	NOUN
admet-2874	106	14	fibrosis	fibrosis	NOUN
admet-2874	106	15	can	can	AUX
admet-2874	106	16	be	be	AUX
admet-2874	106	17	propagated	propagate	VERB
admet-2874	106	18	.	.	PUNCT
admet-2874	107	1	the	the	DET
admet-2874	107	2	cd47	cd47	PROPN
admet-2874	107	3	/	/	SYM
admet-2874	107	4	yap	yap	NOUN
admet-2874	107	5	/	/	SYM
admet-2874	107	6	tead4	tead4	NOUN
admet-2874	107	7	signalling	signal	VERB
admet-2874	107	8	axis	axis	NOUN
admet-2874	107	9	is	be	AUX
admet-2874	107	10	more	more	ADV
admet-2874	107	11	inclined	inclined	ADJ
admet-2874	107	12	to	to	ADP
admet-2874	107	13	the	the	DET
admet-2874	107	14	association	association	NOUN
admet-2874	107	15	of	of	ADP
admet-2874	107	16	non	non	ADJ
admet-2874	107	17	-	-	ADJ
admet-2874	107	18	alcoholic	alcoholic	ADJ
admet-2874	107	19	fatty	fatty	NOUN
admet-2874	107	20	liver	liver	NOUN
admet-2874	107	21	disease	disease	NOUN
admet-2874	107	22	(	(	PUNCT
admet-2874	107	23	nafld	nafld	ADV
admet-2874	107	24	)	)	PUNCT
admet-2874	107	25	.	.	PUNCT
admet-2874	108	1	upregulated	upregulate	VERB
admet-2874	108	2	cd47	cd47	PROPN
admet-2874	108	3	,	,	PUNCT
admet-2874	108	4	triggered	trigger	VERB
admet-2874	108	5	by	by	ADP
admet-2874	108	6	the	the	DET
admet-2874	108	7	yap	yap	PROPN
admet-2874	108	8	and	and	CCONJ
admet-2874	108	9	tead4	tead4	NOUN
admet-2874	108	10	genes	gene	NOUN
admet-2874	108	11	,	,	PUNCT
admet-2874	108	12	leads	lead	VERB
admet-2874	108	13	to	to	ADP
admet-2874	108	14	the	the	DET
admet-2874	108	15	heightened	heightened	ADJ
admet-2874	108	16	activation	activation	NOUN
admet-2874	108	17	of	of	ADP
admet-2874	108	18	hscs	hsc	NOUN
admet-2874	108	19	,	,	PUNCT
admet-2874	108	20	resulting	result	VERB
admet-2874	108	21	in	in	ADP
admet-2874	108	22	liver	liver	NOUN
admet-2874	108	23	fibrosis	fibrosis	NOUN
admet-2874	108	24	.	.	PUNCT
admet-2874	109	1	therefore	therefore	ADV
admet-2874	109	2	,	,	PUNCT
admet-2874	109	3	silencing	silence	VERB
admet-2874	109	4	or	or	CCONJ
admet-2874	109	5	knocking	knock	VERB
admet-2874	109	6	down	down	ADP
admet-2874	109	7	the	the	DET
admet-2874	109	8	cd47	cd47	PROPN
admet-2874	109	9	/	/	SYM
admet-2874	109	10	yap	yap	NOUN
admet-2874	109	11	/	/	SYM
admet-2874	109	12	tead4	tead4	NOUN
admet-2874	109	13	pathway	pathway	NOUN
admet-2874	109	14	can	can	AUX
admet-2874	109	15	inhibit	inhibit	VERB
admet-2874	109	16	the	the	DET
admet-2874	109	17	fibrotic	fibrotic	ADJ
admet-2874	109	18	gene	gene	NOUN
admet-2874	109	19	expression	expression	NOUN
admet-2874	109	20	,	,	PUNCT
admet-2874	109	21	thereby	thereby	ADV
admet-2874	109	22	attenuating	attenuate	VERB
admet-2874	109	23	liver	liver	NOUN
admet-2874	109	24	fibrosis	fibrosis	NOUN
admet-2874	109	25	pathology	pathology	NOUN
admet-2874	109	26	.	.	PUNCT
admet-2874	110	1	in	in	ADP
admet-2874	110	2	this	this	DET
admet-2874	110	3	context	context	NOUN
admet-2874	110	4	,	,	PUNCT
admet-2874	110	5	anti	anti	ADJ
admet-2874	110	6	-	-	ADJ
admet-2874	110	7	cd47	cd47	ADJ
admet-2874	110	8	antibodies	antibody	NOUN
admet-2874	110	9	have	have	AUX
admet-2874	110	10	been	be	AUX
admet-2874	110	11	investigated	investigate	VERB
admet-2874	110	12	for	for	ADP
admet-2874	110	13	their	their	PRON
admet-2874	110	14	potential	potential	NOUN
admet-2874	110	15	to	to	PART
admet-2874	110	16	alleviate	alleviate	VERB
admet-2874	110	17	fibrosis	fibrosis	NOUN
admet-2874	110	18	-	-	PUNCT
admet-2874	110	19	associated	associate	VERB
admet-2874	110	20	inflammation	inflammation	NOUN
admet-2874	110	21	.	.	PUNCT
admet-2874	111	1	moreover	moreover	ADV
admet-2874	111	2	,	,	PUNCT
admet-2874	111	3	pharmacological	pharmacological	ADJ
admet-2874	111	4	intervention	intervention	NOUN
admet-2874	111	5	in	in	ADP
admet-2874	111	6	the	the	DET
admet-2874	111	7	communication	communication	NOUN
admet-2874	111	8	halting	halt	VERB
admet-2874	111	9	between	between	ADP
admet-2874	111	10	yap	yap	PRON
admet-2874	111	11	and	and	CCONJ
admet-2874	111	12	tead4	tead4	NOUN
admet-2874	111	13	will	will	AUX
admet-2874	111	14	further	far	ADV
admet-2874	111	15	potentially	potentially	ADV
admet-2874	111	16	reduce	reduce	VERB
admet-2874	111	17	the	the	DET
admet-2874	111	18	chances	chance	NOUN
admet-2874	111	19	of	of	ADP
admet-2874	111	20	hsc	hsc	NOUN
admet-2874	111	21	activation	activation	NOUN
admet-2874	111	22	and	and	CCONJ
admet-2874	111	23	liver	liver	NOUN
admet-2874	111	24	fibrosis	fibrosis	NOUN
admet-2874	111	25	[	[	X
admet-2874	111	26	48	48	NUM
admet-2874	111	27	]	]	PUNCT
admet-2874	111	28	.	.	PUNCT
admet-2874	112	1	hab18g	hab18g	PROPN
admet-2874	112	2	/	/	SYM
admet-2874	112	3	cd147	cd147	PROPN
admet-2874	112	4	role	role	NOUN
admet-2874	112	5	in	in	ADP
admet-2874	112	6	hepatic	hepatic	ADJ
admet-2874	112	7	stellate	stellate	ADJ
admet-2874	112	8	cell	cell	NOUN
admet-2874	112	9	activation	activation	NOUN
admet-2874	112	10	activation	activation	NOUN
admet-2874	112	11	of	of	ADP
admet-2874	112	12	the	the	DET
admet-2874	112	13	hab18g	hab18g	NOUN
admet-2874	112	14	/	/	SYM
admet-2874	112	15	cd147	cd147	PROPN
admet-2874	112	16	pathway	pathway	NOUN
admet-2874	112	17	has	have	AUX
admet-2874	112	18	been	be	AUX
admet-2874	112	19	reported	report	VERB
admet-2874	112	20	to	to	PART
admet-2874	112	21	stimulate	stimulate	VERB
admet-2874	112	22	hscs	hsc	NOUN
admet-2874	112	23	and	and	CCONJ
admet-2874	112	24	induce	induce	VERB
admet-2874	112	25	the	the	DET
admet-2874	112	26	overexpression	overexpression	NOUN
admet-2874	112	27	of	of	ADP
admet-2874	112	28	fibrogenesis	fibrogenesis	ADJ
admet-2874	112	29	-	-	PUNCT
admet-2874	112	30	associated	associate	VERB
admet-2874	112	31	genes	gene	NOUN
admet-2874	112	32	.	.	PUNCT
admet-2874	113	1	the	the	DET
admet-2874	113	2	hab18g	hab18g	NOUN
admet-2874	113	3	/	/	SYM
admet-2874	113	4	cd147	cd147	PROPN
admet-2874	113	5	protein	protein	NOUN
admet-2874	113	6	is	be	AUX
admet-2874	113	7	expressed	express	VERB
admet-2874	113	8	on	on	ADP
admet-2874	113	9	the	the	DET
admet-2874	113	10	surfaces	surface	NOUN
admet-2874	113	11	of	of	ADP
admet-2874	113	12	hscs	hsc	NOUN
admet-2874	113	13	in	in	ADP
admet-2874	113	14	cases	case	NOUN
admet-2874	113	15	of	of	ADP
admet-2874	113	16	liver	liver	NOUN
admet-2874	113	17	fibrosis	fibrosis	NOUN
admet-2874	113	18	.	.	PUNCT
admet-2874	114	1	this	this	DET
admet-2874	114	2	phenomenon	phenomenon	NOUN
admet-2874	114	3	arises	arise	VERB
admet-2874	114	4	due	due	ADJ
admet-2874	114	5	to	to	ADP
admet-2874	114	6	extracellular	extracellular	ADJ
admet-2874	114	7	matrix	matrix	NOUN
admet-2874	114	8	remodelling	remodelling	NOUN
admet-2874	114	9	and	and	CCONJ
admet-2874	114	10	collagen	collagen	NOUN
admet-2874	114	11	production	production	NOUN
admet-2874	114	12	,	,	PUNCT
admet-2874	114	13	which	which	PRON
admet-2874	114	14	are	be	AUX
admet-2874	114	15	responsible	responsible	ADJ
admet-2874	114	16	for	for	ADP
admet-2874	114	17	liver	liver	NOUN
admet-2874	114	18	fibrosis	fibrosis	NOUN
admet-2874	114	19	.	.	PUNCT
admet-2874	115	1	as	as	ADP
admet-2874	115	2	a	a	DET
admet-2874	115	3	therapeutic	therapeutic	ADJ
admet-2874	115	4	target	target	NOUN
admet-2874	115	5	,	,	PUNCT
admet-2874	115	6	antibodies	antibody	NOUN
admet-2874	115	7	have	have	AUX
admet-2874	115	8	been	be	AUX
admet-2874	115	9	investigated	investigate	VERB
admet-2874	115	10	in	in	ADP
admet-2874	115	11	preclinical	preclinical	ADJ
admet-2874	115	12	animal	animal	NOUN
admet-2874	115	13	studies	study	NOUN
admet-2874	115	14	and	and	CCONJ
admet-2874	115	15	found	find	VERB
admet-2874	115	16	to	to	PART
admet-2874	115	17	be	be	AUX
admet-2874	115	18	effective	effective	ADJ
admet-2874	115	19	in	in	ADP
admet-2874	115	20	downregulating	downregulate	VERB
admet-2874	115	21	the	the	DET
admet-2874	115	22	hab18g	hab18g	NOUN
admet-2874	115	23	/	/	SYM
admet-2874	115	24	cd147	cd147	PROPN
admet-2874	115	25	cascade	cascade	NOUN
admet-2874	115	26	,	,	PUNCT
admet-2874	115	27	thereby	thereby	ADV
admet-2874	115	28	alleviating	alleviate	VERB
admet-2874	115	29	hsc	hsc	NOUN
admet-2874	115	30	-	-	PUNCT
admet-2874	115	31	activated	activate	VERB
admet-2874	115	32	liver	liver	NOUN
admet-2874	115	33	fibrosis	fibrosis	NOUN
admet-2874	115	34	[	[	X
admet-2874	115	35	49	49	NUM
admet-2874	115	36	]	]	PUNCT
admet-2874	115	37	.	.	PUNCT
admet-2874	116	1	therapeutic	therapeutic	ADJ
admet-2874	116	2	approaches	approach	NOUN
admet-2874	116	3	drugs	drug	NOUN
admet-2874	116	4	approved	approve	VERB
admet-2874	116	5	by	by	ADP
admet-2874	116	6	the	the	DET
admet-2874	116	7	us	us	PROPN
admet-2874	116	8	-	-	PUNCT
admet-2874	116	9	fda	fda	PROPN
admet-2874	116	10	and	and	CCONJ
admet-2874	116	11	in	in	ADP
admet-2874	116	12	clinical	clinical	ADJ
admet-2874	116	13	trials	trial	NOUN
admet-2874	116	14	extensive	extensive	ADJ
admet-2874	116	15	research	research	NOUN
admet-2874	116	16	has	have	AUX
admet-2874	116	17	been	be	AUX
admet-2874	116	18	conducted	conduct	VERB
admet-2874	116	19	on	on	ADP
admet-2874	116	20	various	various	ADJ
admet-2874	116	21	pharmacological	pharmacological	ADJ
admet-2874	116	22	methods	method	NOUN
admet-2874	116	23	to	to	PART
admet-2874	116	24	combat	combat	VERB
admet-2874	116	25	liver	liver	NOUN
admet-2874	116	26	fibrosis	fibrosis	NOUN
admet-2874	116	27	,	,	PUNCT
admet-2874	116	28	to	to	PART
admet-2874	116	29	address	address	VERB
admet-2874	116	30	the	the	DET
admet-2874	116	31	fundamental	fundamental	ADJ
admet-2874	116	32	processes	process	NOUN
admet-2874	116	33	driving	drive	VERB
admet-2874	116	34	fibrosis	fibrosis	NOUN
admet-2874	116	35	and	and	CCONJ
admet-2874	116	36	to	to	PART
admet-2874	116	37	develop	develop	VERB
admet-2874	116	38	effective	effective	ADJ
admet-2874	116	39	therapies	therapy	NOUN
admet-2874	116	40	.	.	PUNCT
admet-2874	117	1	one	one	NUM
admet-2874	117	2	of	of	ADP
admet-2874	117	3	the	the	DET
admet-2874	117	4	most	most	ADV
admet-2874	117	5	widely	widely	ADV
admet-2874	117	6	explored	explore	VERB
admet-2874	117	7	targets	target	NOUN
admet-2874	117	8	is	be	AUX
admet-2874	117	9	pparα	pparα	NOUN
admet-2874	117	10	and	and	CCONJ
admet-2874	117	11	pparδ	pparδ	NOUN
admet-2874	117	12	.	.	PUNCT
admet-2874	118	1	in	in	ADP
admet-2874	118	2	a	a	DET
admet-2874	118	3	recently	recently	ADV
admet-2874	118	4	reported	report	VERB
admet-2874	118	5	study	study	NOUN
admet-2874	118	6	[	[	X
admet-2874	118	7	50	50	NUM
admet-2874	118	8	]	]	PUNCT
admet-2874	118	9	,	,	PUNCT
admet-2874	118	10	the	the	DET
admet-2874	118	11	activation	activation	NOUN
admet-2874	118	12	of	of	ADP
admet-2874	118	13	pparα	pparα	NOUN
admet-2874	118	14	and	and	CCONJ
admet-2874	118	15	pparδ	pparδ	NOUN
admet-2874	118	16	has	have	AUX
admet-2874	118	17	been	be	AUX
admet-2874	118	18	observed	observe	VERB
admet-2874	118	19	to	to	PART
admet-2874	118	20	alter	alter	VERB
admet-2874	118	21	metabolic	metabolic	NOUN
admet-2874	118	22	pathways	pathway	NOUN
admet-2874	118	23	and	and	CCONJ
admet-2874	118	24	decrease	decrease	VERB
admet-2874	118	25	inflammation	inflammation	NOUN
admet-2874	118	26	,	,	PUNCT
admet-2874	118	27	both	both	PRON
admet-2874	118	28	of	of	ADP
admet-2874	118	29	which	which	PRON
admet-2874	118	30	are	be	AUX
admet-2874	118	31	important	important	ADJ
admet-2874	118	32	elements	element	NOUN
admet-2874	118	33	in	in	ADP
admet-2874	118	34	the	the	DET
admet-2874	118	35	development	development	NOUN
admet-2874	118	36	of	of	ADP
admet-2874	118	37	liver	liver	NOUN
admet-2874	118	38	fibrosis	fibrosis	NOUN
admet-2874	118	39	.	.	PUNCT
admet-2874	119	1	it	it	PRON
admet-2874	119	2	has	have	AUX
admet-2874	119	3	been	be	AUX
admet-2874	119	4	demonstrated	demonstrate	VERB
admet-2874	119	5	that	that	SCONJ
admet-2874	119	6	elafibranor	elafibranor	NOUN
admet-2874	119	7	effectively	effectively	ADV
admet-2874	119	8	enhances	enhance	VERB
admet-2874	119	9	markers	marker	NOUN
admet-2874	119	10	for	for	ADP
admet-2874	119	11	liver	liver	NOUN
admet-2874	119	12	fibrosis	fibrosis	NOUN
admet-2874	119	13	and	and	CCONJ
admet-2874	119	14	slows	slow	VERB
admet-2874	119	15	down	down	ADP
admet-2874	119	16	the	the	DET
admet-2874	119	17	progression	progression	NOUN
admet-2874	119	18	of	of	ADP
admet-2874	119	19	the	the	DET
admet-2874	119	20	condition	condition	NOUN
admet-2874	119	21	in	in	ADP
admet-2874	119	22	a	a	DET
admet-2874	119	23	non	non	ADJ
admet-2874	119	24	-	-	ADJ
admet-2874	119	25	alcoholic	alcoholic	ADJ
admet-2874	119	26	steatohepatitis	steatohepatitis	NOUN
admet-2874	119	27	animal	animal	NOUN
admet-2874	119	28	model	model	NOUN
admet-2874	119	29	[	[	X
admet-2874	119	30	50	50	NUM
admet-2874	119	31	]	]	PUNCT
admet-2874	119	32	.	.	PUNCT
admet-2874	120	1	pioglitazone	pioglitazone	NOUN
admet-2874	120	2	,	,	PUNCT
admet-2874	120	3	another	another	DET
admet-2874	120	4	pparγ	pparγ	ADJ
admet-2874	120	5	agonist	agonist	NOUN
admet-2874	120	6	,	,	PUNCT
admet-2874	120	7	has	have	AUX
admet-2874	120	8	also	also	ADV
admet-2874	120	9	been	be	AUX
admet-2874	120	10	investigated	investigate	VERB
admet-2874	120	11	for	for	ADP
admet-2874	120	12	its	its	PRON
admet-2874	120	13	ability	ability	NOUN
admet-2874	120	14	to	to	PART
admet-2874	120	15	treat	treat	VERB
admet-2874	120	16	liver	liver	NOUN
admet-2874	120	17	fibrosis	fibrosis	NOUN
admet-2874	120	18	.	.	PUNCT
admet-2874	121	1	huang	huang	PROPN
admet-2874	121	2	and	and	CCONJ
admet-2874	121	3	colleagues	colleague	NOUN
admet-2874	121	4	revealed	reveal	VERB
admet-2874	121	5	that	that	SCONJ
admet-2874	121	6	pioglitazone	pioglitazone	NOUN
admet-2874	121	7	enhanced	enhance	VERB
admet-2874	121	8	liver	liver	NOUN
admet-2874	121	9	histology	histology	NOUN
admet-2874	121	10	and	and	CCONJ
admet-2874	121	11	lowered	lower	VERB
admet-2874	121	12	the	the	DET
admet-2874	121	13	expression	expression	NOUN
admet-2874	121	14	of	of	ADP
admet-2874	121	15	fibrogenic	fibrogenic	ADJ
admet-2874	121	16	genes	gene	NOUN
admet-2874	121	17	in	in	ADP
admet-2874	121	18	an	an	DET
admet-2874	121	19	animal	animal	NOUN
admet-2874	121	20	model	model	NOUN
admet-2874	121	21	of	of	ADP
admet-2874	121	22	non	non	ADJ
admet-2874	121	23	-	-	ADJ
admet-2874	121	24	alcoholic	alcoholic	ADJ
admet-2874	121	25	steatohepatitis	steatohepatitis	NOUN
admet-2874	122	1	[	[	X
admet-2874	122	2	51	51	NUM
admet-2874	122	3	]	]	PUNCT
admet-2874	122	4	.	.	PUNCT
admet-2874	123	1	the	the	DET
admet-2874	123	2	fxr	fxr	PROPN
admet-2874	123	3	,	,	PUNCT
admet-2874	123	4	a	a	DET
admet-2874	123	5	nuclear	nuclear	ADJ
admet-2874	123	6	receptor	receptor	NOUN
admet-2874	123	7	crucial	crucial	ADJ
admet-2874	123	8	for	for	ADP
admet-2874	123	9	maintaining	maintain	VERB
admet-2874	123	10	bile	bile	NOUN
admet-2874	123	11	acid	acid	NOUN
admet-2874	123	12	equilibrium	equilibrium	NOUN
admet-2874	123	13	and	and	CCONJ
admet-2874	123	14	regulating	regulate	VERB
admet-2874	123	15	liver	liver	NOUN
admet-2874	123	16	metabolism	metabolism	NOUN
admet-2874	123	17	,	,	PUNCT
admet-2874	123	18	is	be	AUX
admet-2874	123	19	strongly	strongly	ADV
admet-2874	123	20	and	and	CCONJ
admet-2874	123	21	selectively	selectively	ADV
admet-2874	123	22	stimulated	stimulate	VERB
admet-2874	123	23	by	by	ADP
admet-2874	123	24	tropifexor	tropifexor	PROPN
admet-2874	123	25	.	.	PUNCT
admet-2874	124	1	furthermore	furthermore	ADV
admet-2874	124	2	,	,	PUNCT
admet-2874	124	3	some	some	DET
admet-2874	124	4	researchers	researcher	NOUN
admet-2874	124	5	observed	observe	VERB
admet-2874	124	6	that	that	SCONJ
admet-2874	124	7	tropifexor	tropifexor	PROPN
admet-2874	124	8	decreases	decrease	VERB
admet-2874	124	9	liver	liver	NOUN
admet-2874	124	10	fibrosis	fibrosis	NOUN
admet-2874	124	11	and	and	CCONJ
admet-2874	124	12	enhances	enhance	VERB
admet-2874	124	13	various	various	ADJ
admet-2874	124	14	indicators	indicator	NOUN
admet-2874	124	15	of	of	ADP
admet-2874	124	16	liver	liver	NOUN
admet-2874	124	17	well	well	ADV
admet-2874	124	18	-	-	PUNCT
admet-2874	124	19	being	being	NOUN
admet-2874	124	20	in	in	ADP
admet-2874	124	21	an	an	DET
admet-2874	124	22	animal	animal	NOUN
admet-2874	124	23	model	model	NOUN
admet-2874	124	24	with	with	ADP
admet-2874	124	25	non	non	ADJ
admet-2874	124	26	-	-	ADJ
admet-2874	124	27	alcoholic	alcoholic	ADJ
admet-2874	124	28	fatty	fatty	NOUN
admet-2874	124	29	liver	liver	NOUN
admet-2874	124	30	disease	disease	NOUN
admet-2874	124	31	[	[	X
admet-2874	124	32	52	52	NUM
admet-2874	124	33	]	]	PUNCT
admet-2874	124	34	.	.	PUNCT
admet-2874	125	1	the	the	DET
admet-2874	125	2	researchers	researcher	NOUN
admet-2874	125	3	propose	propose	VERB
admet-2874	125	4	that	that	SCONJ
admet-2874	125	5	emricasan	emricasan	NOUN
admet-2874	125	6	's	's	PART
admet-2874	125	7	anti	anti	ADJ
admet-2874	125	8	-	-	ADJ
admet-2874	125	9	fibrotic	fibrotic	ADJ
admet-2874	125	10	effects	effect	NOUN
admet-2874	125	11	result	result	VERB
admet-2874	125	12	from	from	ADP
admet-2874	125	13	its	its	PRON
admet-2874	125	14	ability	ability	NOUN
admet-2874	125	15	to	to	PART
admet-2874	125	16	inhibit	inhibit	VERB
admet-2874	125	17	caspase	caspase	NOUN
admet-2874	125	18	-	-	PUNCT
admet-2874	125	19	mediated	mediate	VERB
admet-2874	125	20	apoptosis	apoptosis	NOUN
admet-2874	125	21	and	and	CCONJ
admet-2874	125	22	inflammation	inflammation	NOUN
admet-2874	125	23	,	,	PUNCT
admet-2874	125	24	both	both	PRON
admet-2874	125	25	of	of	ADP
admet-2874	125	26	which	which	PRON
admet-2874	125	27	play	play	VERB
admet-2874	125	28	crucial	crucial	ADJ
admet-2874	125	29	roles	role	NOUN
admet-2874	125	30	in	in	ADP
admet-2874	125	31	the	the	DET
admet-2874	125	32	development	development	NOUN
admet-2874	125	33	of	of	ADP
admet-2874	125	34	liver	liver	NOUN
admet-2874	125	35	fibrosis	fibrosis	NOUN
admet-2874	125	36	[	[	X
admet-2874	125	37	53	53	NUM
admet-2874	125	38	]	]	PUNCT
admet-2874	125	39	.	.	PUNCT
admet-2874	126	1	to	to	PART
admet-2874	126	2	treat	treat	VERB
admet-2874	126	3	this	this	DET
admet-2874	126	4	disease	disease	NOUN
admet-2874	126	5	,	,	PUNCT
admet-2874	126	6	several	several	ADJ
admet-2874	126	7	medications	medication	NOUN
admet-2874	126	8	have	have	AUX
admet-2874	126	9	been	be	AUX
admet-2874	126	10	examined	examine	VERB
admet-2874	126	11	,	,	PUNCT
admet-2874	126	12	which	which	PRON
admet-2874	126	13	are	be	AUX
admet-2874	126	14	discussed	discuss	VERB
admet-2874	126	15	in	in	ADP
admet-2874	126	16	table	table	NOUN
admet-2874	126	17	1	1	NUM
admet-2874	126	18	.	.	PUNCT
admet-2874	127	1	recently	recently	ADV
admet-2874	127	2	,	,	PUNCT
admet-2874	127	3	the	the	DET
admet-2874	127	4	fda	fda	PROPN
admet-2874	127	5	approved	approve	VERB
admet-2874	127	6	resmetirom	resmetirom	ADP
admet-2874	127	7	for	for	ADP
admet-2874	127	8	non	non	ADJ
admet-2874	127	9	-	-	ADJ
admet-2874	127	10	cirrhotic	cirrhotic	ADJ
admet-2874	127	11	mash	mash	NOUN
admet-2874	127	12	with	with	ADP
admet-2874	127	13	moderate	moderate	ADJ
admet-2874	127	14	to	to	ADP
admet-2874	127	15	advanced	advanced	ADJ
admet-2874	127	16	fibrosis	fibrosis	NOUN
admet-2874	127	17	,	,	PUNCT
admet-2874	127	18	based	base	VERB
admet-2874	127	19	on	on	ADP
admet-2874	127	20	a	a	DET
admet-2874	127	21	phase	phase	NOUN
admet-2874	127	22	3	3	NUM
admet-2874	127	23	clinical	clinical	ADJ
admet-2874	127	24	trial	trial	NOUN
admet-2874	127	25	(	(	PUNCT
admet-2874	127	26	nct03900429	nct03900429	NOUN
admet-2874	127	27	)	)	PUNCT
admet-2874	127	28	,	,	PUNCT
admet-2874	127	29	which	which	PRON
admet-2874	127	30	demonstrated	demonstrate	VERB
admet-2874	127	31	mash	mash	NOUN
admet-2874	127	32	resolution	resolution	NOUN
admet-2874	127	33	with	with	ADP
admet-2874	127	34	at	at	ADV
admet-2874	127	35	least	least	ADV
admet-2874	127	36	one	one	NUM
admet-2874	127	37	stage	stage	NOUN
admet-2874	127	38	improvement	improvement	NOUN
admet-2874	127	39	in	in	ADP
admet-2874	127	40	fibrosis	fibrosis	NOUN
admet-2874	127	41	[	[	X
admet-2874	127	42	54	54	NUM
admet-2874	127	43	]	]	PUNCT
admet-2874	127	44	.	.	PUNCT
admet-2874	128	1	this	this	DET
admet-2874	128	2	drug	drug	NOUN
admet-2874	128	3	acts	act	VERB
admet-2874	128	4	by	by	ADP
admet-2874	128	5	targeting	target	VERB
admet-2874	128	6	the	the	DET
admet-2874	128	7	thyroid	thyroid	NOUN
admet-2874	128	8	hormone	hormone	NOUN
admet-2874	128	9	receptor	receptor	NOUN
admet-2874	128	10	(	(	PUNCT
admet-2874	128	11	thr)-β	thr)-β	NOUN
admet-2874	128	12	,	,	PUNCT
admet-2874	128	13	which	which	PRON
admet-2874	128	14	is	be	AUX
admet-2874	128	15	present	present	ADJ
admet-2874	128	16	in	in	ADP
admet-2874	128	17	the	the	DET
admet-2874	128	18	liver	liver	NOUN
admet-2874	128	19	.	.	PUNCT
admet-2874	129	1	the	the	DET
admet-2874	129	2	detailed	detailed	ADJ
admet-2874	129	3	molecular	molecular	ADJ
admet-2874	129	4	mechanism	mechanism	NOUN
admet-2874	129	5	of	of	ADP
admet-2874	129	6	the	the	DET
admet-2874	129	7	effects	effect	NOUN
admet-2874	129	8	is	be	AUX
admet-2874	129	9	presented	present	VERB
admet-2874	129	10	in	in	ADP
admet-2874	129	11	figure	figure	NOUN
admet-2874	129	12	2	2	NUM
admet-2874	129	13	.	.	PUNCT
admet-2874	130	1	pirfenidone	pirfenidone	NOUN
admet-2874	130	2	is	be	AUX
admet-2874	130	3	an	an	DET
admet-2874	130	4	antifibrogenic	antifibrogenic	ADJ
admet-2874	130	5	and	and	CCONJ
admet-2874	130	6	antiinflammatory	antiinflammatory	NOUN
admet-2874	130	7	drug	drug	NOUN
admet-2874	130	8	and	and	CCONJ
admet-2874	130	9	is	be	AUX
admet-2874	130	10	approved	approve	VERB
admet-2874	130	11	by	by	ADP
admet-2874	130	12	the	the	DET
admet-2874	130	13	us	us	PROPN
admet-2874	130	14	-	-	PUNCT
admet-2874	130	15	fda	fda	PROPN
admet-2874	130	16	for	for	ADP
admet-2874	130	17	idiopathic	idiopathic	ADJ
admet-2874	130	18	pulmonary	pulmonary	ADJ
admet-2874	130	19	fibrosis	fibrosis	NOUN
admet-2874	130	20	and	and	CCONJ
admet-2874	130	21	is	be	AUX
admet-2874	130	22	currently	currently	ADV
admet-2874	130	23	under	under	ADP
admet-2874	130	24	investigation	investigation	NOUN
admet-2874	130	25	for	for	ADP
admet-2874	130	26	liver	liver	NOUN
admet-2874	130	27	fibrosis	fibrosis	NOUN
admet-2874	130	28	and	and	CCONJ
admet-2874	130	29	various	various	ADJ
admet-2874	130	30	other	other	ADJ
admet-2874	130	31	fibrotic	fibrotic	ADJ
admet-2874	130	32	diseases	disease	NOUN
admet-2874	130	33	.	.	PUNCT
admet-2874	131	1	it	it	PRON
admet-2874	131	2	acts	act	VERB
admet-2874	131	3	by	by	ADP
admet-2874	131	4	affecting	affect	VERB
admet-2874	131	5	multiple	multiple	ADJ
admet-2874	131	6	molecular	molecular	ADJ
admet-2874	131	7	targets	target	NOUN
admet-2874	131	8	,	,	PUNCT
admet-2874	131	9	notably	notably	ADV
admet-2874	131	10	inhibiting	inhibit	VERB
admet-2874	131	11	tgf	tgf	PROPN
admet-2874	131	12	-	-	PUNCT
admet-2874	131	13	β	β	X
admet-2874	131	14	and	and	CCONJ
admet-2874	131	15	reducing	reduce	VERB
admet-2874	131	16	pro	pro	ADJ
admet-2874	131	17	-	-	ADJ
admet-2874	131	18	inflammatory	inflammatory	ADJ
admet-2874	131	19	cytokines	cytokine	NOUN
admet-2874	131	20	,	,	PUNCT
admet-2874	131	21	leading	lead	VERB
admet-2874	131	22	to	to	ADP
admet-2874	131	23	alleviated	alleviated	ADJ
admet-2874	131	24	fibrosis	fibrosis	NOUN
admet-2874	131	25	(	(	PUNCT
admet-2874	131	26	figure	figure	NOUN
admet-2874	131	27	3b	3b	NUM
admet-2874	131	28	)	)	PUNCT
admet-2874	131	29	.	.	PUNCT
admet-2874	132	1	its	its	PRON
admet-2874	132	2	hydroxy	hydroxy	PROPN
admet-2874	132	3	analog	analog	NOUN
admet-2874	132	4	,	,	PUNCT
admet-2874	132	5	hydronidone	hydronidone	PROPN
admet-2874	132	6	,	,	PUNCT
admet-2874	132	7	has	have	AUX
admet-2874	132	8	been	be	AUX
admet-2874	132	9	proven	prove	VERB
admet-2874	132	10	better	well	ADJ
admet-2874	132	11	for	for	ADP
admet-2874	132	12	the	the	DET
admet-2874	132	13	therapy	therapy	NOUN
admet-2874	132	14	of	of	ADP
admet-2874	132	15	liver	liver	NOUN
admet-2874	132	16	fibrosis	fibrosis	NOUN
admet-2874	132	17	owing	owe	VERB
admet-2874	132	18	to	to	ADP
admet-2874	132	19	its	its	PRON
admet-2874	132	20	high	high	ADJ
admet-2874	132	21	hepatic	hepatic	ADJ
admet-2874	132	22	safety	safety	NOUN
admet-2874	132	23	(	(	PUNCT
admet-2874	132	24	due	due	ADP
admet-2874	132	25	to	to	ADP
admet-2874	132	26	metabolism	metabolism	NOUN
admet-2874	132	27	by	by	ADP
admet-2874	132	28	phase	phase	NOUN
admet-2874	132	29	2	2	NUM
admet-2874	132	30	transformation	transformation	NOUN
admet-2874	132	31	instead	instead	ADV
admet-2874	132	32	of	of	ADP
admet-2874	132	33	phase	phase	NOUN
admet-2874	132	34	i	i	PRON
admet-2874	132	35	transformation	transformation	NOUN
admet-2874	132	36	)	)	PUNCT
admet-2874	132	37	.	.	PUNCT
admet-2874	133	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	133	2	a.	a.	NOUN
admet-2874	133	3	singh	singh	PROPN
admet-2874	133	4	et	et	PROPN
admet-2874	133	5	al	al	PROPN
admet-2874	133	6	.	.	PROPN
admet-2874	133	7	admet	admet	PROPN
admet-2874	133	8	&	&	CCONJ
admet-2874	133	9	dmpk	dmpk	PROPN
admet-2874	133	10	13(4	13(4	NUM
admet-2874	133	11	)	)	PUNCT
admet-2874	133	12	(	(	PUNCT
admet-2874	133	13	2025	2025	NUM
admet-2874	133	14	)	)	PUNCT
admet-2874	133	15	2874	2874	NUM
admet-2874	133	16	6	6	NUM
admet-2874	133	17	table	table	NOUN
admet-2874	133	18	1	1	NUM
admet-2874	133	19	.	.	PUNCT
admet-2874	134	1	drugs	drug	NOUN
admet-2874	134	2	/	/	SYM
admet-2874	134	3	compounds	compound	NOUN
admet-2874	134	4	used	use	VERB
admet-2874	134	5	in	in	ADP
admet-2874	134	6	clinics	clinic	NOUN
admet-2874	134	7	to	to	PART
admet-2874	134	8	treat	treat	VERB
admet-2874	134	9	liver	liver	NOUN
admet-2874	134	10	fibrosis	fibrosis	NOUN
admet-2874	134	11	name	name	VERB
admet-2874	134	12	original	original	ADJ
admet-2874	134	13	indication	indication	NOUN
admet-2874	134	14	target	target	NOUN
admet-2874	134	15	current	current	ADJ
admet-2874	134	16	status	status	NOUN
admet-2874	134	17	/	/	SYM
admet-2874	134	18	effects	effect	NOUN
admet-2874	134	19	ref	ref	VERB
admet-2874	134	20	.	.	PUNCT
admet-2874	135	1	belapectin	belapectin	VERB
admet-2874	135	2	liver	liver	NOUN
admet-2874	135	3	fibrosis	fibrosis	NOUN
admet-2874	135	4	galectin-3	galectin-3	PROPN
admet-2874	135	5	antagonist	antagonist	NOUN
admet-2874	135	6	nct02462967	nct02462967	NOUN
admet-2874	135	7	phase	phase	NOUN
admet-2874	135	8	2b	2b	NOUN
admet-2874	135	9	:	:	PUNCT
admet-2874	135	10	nct04365868	nct04365868	ADJ
admet-2874	135	11	phase	phase	NOUN
admet-2874	135	12	2/3	2/3	NUM
admet-2874	135	13	prevention	prevention	NOUN
admet-2874	135	14	of	of	ADP
admet-2874	135	15	oesophageal	oesophageal	ADJ
admet-2874	135	16	varices	varix	NOUN
admet-2874	135	17	[	[	X
admet-2874	135	18	58,59	58,59	X
admet-2874	135	19	]	]	X
admet-2874	135	20	saroglitazar	saroglitazar	NOUN
admet-2874	135	21	diabetic	diabetic	PROPN
admet-2874	135	22	dyslipidaemia	dyslipidaemia	NOUN
admet-2874	135	23	pparα	pparα	NOUN
admet-2874	135	24	/	/	SYM
admet-2874	135	25	γ	γ	NOUN
admet-2874	135	26	agonist	agonist	NOUN
admet-2874	135	27	phase	phase	NOUN
admet-2874	135	28	2	2	NUM
admet-2874	135	29	[	[	SYM
admet-2874	135	30	60	60	NUM
admet-2874	135	31	]	]	PUNCT
admet-2874	135	32	elafibranor	elafibranor	NOUN
admet-2874	135	33	primary	primary	ADJ
admet-2874	135	34	biliary	biliary	NOUN
admet-2874	135	35	cholangitis	cholangitis	NOUN
admet-2874	135	36	pparα	pparα	NOUN
admet-2874	135	37	and	and	CCONJ
admet-2874	135	38	pparδ	pparδ	NOUN
admet-2874	135	39	agonist	agonist	NOUN
admet-2874	135	40	not	not	PART
admet-2874	135	41	effective	effective	ADJ
admet-2874	135	42	phase	phase	NOUN
admet-2874	135	43	3	3	NUM
admet-2874	135	44	[	[	SYM
admet-2874	135	45	61	61	NUM
admet-2874	135	46	]	]	PUNCT
admet-2874	135	47	seladelpar	seladelpar	NOUN
admet-2874	135	48	primary	primary	ADJ
admet-2874	135	49	biliary	biliary	NOUN
admet-2874	135	50	cholangitis	cholangitis	NOUN
admet-2874	135	51	pparδ	pparδ	NOUN
admet-2874	135	52	agonist	agonist	NOUN
admet-2874	135	53	accelerated	accelerate	VERB
admet-2874	135	54	approval	approval	NOUN
admet-2874	135	55	us	us	PROPN
admet-2874	135	56	-	-	PUNCT
admet-2874	135	57	fda	fda	PROPN
admet-2874	136	1	[	[	X
admet-2874	136	2	61	61	NUM
admet-2874	136	3	]	]	PUNCT
admet-2874	136	4	resmetirom	resmetirom	VERB
admet-2874	136	5	rezdiffra	rezdiffra	NOUN
admet-2874	136	6	™	™	VERB
admet-2874	136	7	nash	nash	NOUN
admet-2874	136	8	with	with	ADP
admet-2874	136	9	fibrosis	fibrosis	NOUN
admet-2874	136	10	thr	thr	PROPN
admet-2874	136	11	-	-	PUNCT
admet-2874	136	12	β	β	NOUN
admet-2874	136	13	agonist	agonist	NOUN
admet-2874	136	14	accelerated	accelerate	VERB
admet-2874	136	15	approval	approval	NOUN
admet-2874	136	16	us	us	PROPN
admet-2874	136	17	-	-	PUNCT
admet-2874	136	18	fda	fda	PROPN
admet-2874	136	19	[	[	X
admet-2874	136	20	62	62	NUM
admet-2874	136	21	]	]	PUNCT
admet-2874	136	22	liraglutide	liraglutide	NOUN
admet-2874	136	23	diabetes	diabetes	NOUN
admet-2874	136	24	and	and	CCONJ
admet-2874	136	25	obesity	obesity	NOUN
admet-2874	136	26	glp-1	glp-1	NOUN
admet-2874	136	27	analog	analog	NOUN
admet-2874	136	28	diabetes	diabetes	NOUN
admet-2874	136	29	associated	associate	VERB
admet-2874	136	30	liver	liver	NOUN
admet-2874	136	31	fibrosis	fibrosis	NOUN
admet-2874	136	32	[	[	X
admet-2874	136	33	63	63	NUM
admet-2874	136	34	]	]	SYM
admet-2874	136	35	semaglutide	semaglutide	ADJ
admet-2874	136	36	metabolic	metabolic	NOUN
admet-2874	136	37	disorders	disorder	NOUN
admet-2874	136	38	associated	associate	VERB
admet-2874	136	39	steatohepatitis	steatohepatitis	PROPN
admet-2874	136	40	linked	link	VERB
admet-2874	136	41	liver	liver	NOUN
admet-2874	136	42	fibrosis	fibrosis	NOUN
admet-2874	136	43	[	[	X
admet-2874	136	44	64	64	NUM
admet-2874	136	45	]	]	PUNCT
admet-2874	136	46	obeticholic	obeticholic	ADJ
admet-2874	136	47	acid	acid	PROPN
admet-2874	136	48	liver	liver	NOUN
admet-2874	136	49	fibrosis	fibrosis	NOUN
admet-2874	136	50	fxr	fxr	NOUN
admet-2874	136	51	agonists	agonist	NOUN
admet-2874	136	52	accelerated	accelerate	VERB
admet-2874	136	53	approval	approval	NOUN
admet-2874	136	54	us	us	PROPN
admet-2874	136	55	-	-	PUNCT
admet-2874	136	56	fda	fda	PROPN
admet-2874	136	57	currently	currently	ADV
admet-2874	136	58	restricted	restrict	VERB
admet-2874	136	59	use	use	NOUN
admet-2874	136	60	[	[	X
admet-2874	136	61	65	65	NUM
admet-2874	136	62	]	]	SYM
admet-2874	136	63	setanaxib	setanaxib	ADJ
admet-2874	136	64	liver	liver	NOUN
admet-2874	136	65	fibrosis	fibrosis	NOUN
admet-2874	136	66	nox1	nox1	PROPN
admet-2874	136	67	,	,	PUNCT
admet-2874	136	68	nox4	nox4	PROPN
admet-2874	136	69	inhibitor	inhibitor	NOUN
admet-2874	136	70	,	,	PUNCT
admet-2874	136	71	nadph	nadph	ADJ
admet-2874	136	72	oxidase	oxidase	NOUN
admet-2874	136	73	fast	fast	ADJ
admet-2874	136	74	track	track	NOUN
admet-2874	136	75	approval	approval	NOUN
admet-2874	136	76	,	,	PUNCT
admet-2874	136	77	fda	fda	PROPN
admet-2874	136	78	(	(	PUNCT
admet-2874	136	79	orphan	orphan	NOUN
admet-2874	136	80	)	)	PUNCT
admet-2874	137	1	[	[	X
admet-2874	137	2	66	66	NUM
admet-2874	137	3	]	]	PUNCT
admet-2874	137	4	pentoxifylline	pentoxifylline	NOUN
admet-2874	137	5	peripheral	peripheral	ADJ
admet-2874	137	6	vascular	vascular	ADJ
admet-2874	137	7	disease	disease	NOUN
admet-2874	137	8	non	non	ADJ
admet-2874	137	9	-	-	ADJ
admet-2874	137	10	specific	specific	ADJ
admet-2874	137	11	phosphodiesterase	phosphodiesterase	NOUN
admet-2874	137	12	inhibitor	inhibitor	NOUN
admet-2874	137	13	benefits	benefit	NOUN
admet-2874	137	14	in	in	ADP
admet-2874	137	15	small	small	ADJ
admet-2874	137	16	clinical	clinical	ADJ
admet-2874	137	17	trials	trial	NOUN
admet-2874	137	18	not	not	PART
admet-2874	137	19	approved	approve	VERB
admet-2874	137	20	by	by	ADP
admet-2874	137	21	us	us	PROPN
admet-2874	137	22	-	-	PUNCT
admet-2874	137	23	fda	fda	PROPN
admet-2874	137	24	[	[	X
admet-2874	137	25	67	67	NUM
admet-2874	137	26	]	]	X
admet-2874	137	27	hydronidone	hydronidone	PROPN
admet-2874	137	28	na	na	X
admet-2874	137	29	wnt	wnt	PROPN
admet-2874	137	30	/	/	SYM
admet-2874	137	31	β	β	NOUN
admet-2874	137	32	-	-	ADJ
admet-2874	137	33	catenin	catenin	ADJ
admet-2874	137	34	pathway	pathway	NOUN
admet-2874	137	35	inhibitor	inhibitor	NOUN
admet-2874	137	36	demonstrated	demonstrate	VERB
admet-2874	137	37	efficacy	efficacy	NOUN
admet-2874	137	38	in	in	ADP
admet-2874	137	39	phase	phase	NOUN
admet-2874	137	40	2	2	NUM
admet-2874	137	41	and	and	CCONJ
admet-2874	137	42	phase	phase	NOUN
admet-2874	137	43	3	3	NUM
admet-2874	137	44	trials	trial	NOUN
admet-2874	137	45	[	[	X
admet-2874	137	46	68	68	NUM
admet-2874	137	47	]	]	PUNCT
admet-2874	137	48	fluorofenidone	fluorofenidone	NOUN
admet-2874	137	49	na	na	AUX
admet-2874	137	50	inhibited	inhibit	VERB
admet-2874	137	51	tgfβ1	tgfβ1	PROPN
admet-2874	137	52	/	/	SYM
admet-2874	137	53	smad	smad	PROPN
admet-2874	137	54	and	and	CCONJ
admet-2874	137	55	mapk	mapk	NOUN
admet-2874	137	56	signalling	signal	VERB
admet-2874	137	57	limited	limited	ADJ
admet-2874	137	58	clinical	clinical	ADJ
admet-2874	137	59	trial	trial	NOUN
admet-2874	137	60	data	datum	NOUN
admet-2874	137	61	[	[	X
admet-2874	137	62	69	69	NUM
admet-2874	137	63	]	]	PUNCT
admet-2874	137	64	tirzepatide	tirzepatide	ADJ
admet-2874	137	65	type	type	NOUN
admet-2874	137	66	2	2	NUM
admet-2874	137	67	diabetes	diabetes	NOUN
admet-2874	137	68	glp-1	glp-1	NOUN
admet-2874	137	69	and	and	CCONJ
admet-2874	137	70	gip	gip	NOUN
admet-2874	137	71	agonist	agonist	NOUN
admet-2874	137	72	phase	phase	NOUN
admet-2874	137	73	2	2	NUM
admet-2874	137	74	resolution	resolution	NOUN
admet-2874	137	75	of	of	ADP
admet-2874	137	76	mash	mash	NOUN
admet-2874	137	77	without	without	ADP
admet-2874	137	78	worsening	worsen	VERB
admet-2874	137	79	liver	liver	NOUN
admet-2874	137	80	fibrosis	fibrosis	NOUN
admet-2874	137	81	[	[	X
admet-2874	137	82	70	70	NUM
admet-2874	137	83	]	]	X
admet-2874	137	84	gs-0976	gs-0976	ADJ
admet-2874	137	85	/	/	SYM
admet-2874	137	86	firsocostat	firsocostat	NOUN
admet-2874	137	87	na	na	ADP
admet-2874	137	88	acetyl	acetyl	NOUN
admet-2874	137	89	-	-	PUNCT
admet-2874	137	90	coa	coa	NOUN
admet-2874	137	91	carboxylase	carboxylase	NOUN
admet-2874	137	92	(	(	PUNCT
admet-2874	137	93	acc	acc	PROPN
admet-2874	137	94	)	)	PUNCT
admet-2874	137	95	phase	phase	NOUN
admet-2874	137	96	2	2	NUM
admet-2874	137	97	nash	nash	NOUN
admet-2874	138	1	[	[	X
admet-2874	138	2	71	71	NUM
admet-2874	138	3	]	]	X
admet-2874	138	4	pegbelfermin	pegbelfermin	NOUN
admet-2874	138	5	na	na	PART
admet-2874	138	6	fgf21	fgf21	NOUN
admet-2874	138	7	analogue	analogue	NOUN
admet-2874	138	8	failed	fail	VERB
admet-2874	138	9	phase	phase	NOUN
admet-2874	138	10	2b	2b	NOUN
admet-2874	138	11	[	[	X
admet-2874	138	12	72	72	NUM
admet-2874	138	13	]	]	PUNCT
admet-2874	138	14	aldafermin	aldafermin	NOUN
admet-2874	138	15	na	na	NOUN
admet-2874	138	16	fgf19	fgf19	NOUN
admet-2874	138	17	analogue	analogue	NOUN
admet-2874	138	18	phase	phase	NOUN
admet-2874	138	19	2/3	2/3	NUM
admet-2874	138	20	promising	promising	ADJ
admet-2874	138	21	results	result	NOUN
admet-2874	138	22	[	[	X
admet-2874	138	23	73	73	NUM
admet-2874	138	24	]	]	SYM
admet-2874	138	25	aramchol	aramchol	NOUN
admet-2874	138	26	metabolic	metabolic	NOUN
admet-2874	138	27	disorders	disorder	NOUN
admet-2874	138	28	inhibitor	inhibitor	NOUN
admet-2874	138	29	of	of	ADP
admet-2874	138	30	de	de	X
admet-2874	138	31	novo	novo	PROPN
admet-2874	138	32	lipid	lipid	NOUN
admet-2874	138	33	synthesis	synthesis	NOUN
admet-2874	138	34	effective	effective	ADJ
admet-2874	138	35	in	in	ADP
admet-2874	138	36	phase	phase	NOUN
admet-2874	138	37	3	3	NUM
admet-2874	138	38	armor	armor	NOUN
admet-2874	138	39	study	study	NOUN
admet-2874	138	40	[	[	X
admet-2874	138	41	74	74	NUM
admet-2874	138	42	]	]	PUNCT
admet-2874	138	43	figure	figure	NOUN
admet-2874	138	44	2	2	NUM
admet-2874	138	45	.	.	PUNCT
admet-2874	138	46	mechanisms	mechanism	NOUN
admet-2874	138	47	of	of	ADP
admet-2874	138	48	action	action	NOUN
admet-2874	138	49	of	of	ADP
admet-2874	138	50	thyroid	thyroid	NOUN
admet-2874	138	51	hormones	hormone	NOUN
admet-2874	138	52	and	and	CCONJ
admet-2874	138	53	resmetirom	resmetirom	VERB
admet-2874	138	54	in	in	ADP
admet-2874	138	55	regulation	regulation	NOUN
admet-2874	138	56	of	of	ADP
admet-2874	138	57	hepatocyte	hepatocyte	NOUN
admet-2874	138	58	lipid	lipid	NOUN
admet-2874	138	59	metabolism	metabolism	NOUN
admet-2874	138	60	.	.	PUNCT
admet-2874	138	61	,	,	PUNCT
admet-2874	138	62	thyroxine	thyroxine	NOUN
admet-2874	138	63	(	(	PUNCT
admet-2874	138	64	t4	t4	PROPN
admet-2874	138	65	)	)	PUNCT
admet-2874	138	66	,	,	PUNCT
admet-2874	138	67	iodothyronine	iodothyronine	ADJ
admet-2874	138	68	deiodinase	deiodinase	NOUN
admet-2874	138	69	1	1	NUM
admet-2874	138	70	(	(	PUNCT
admet-2874	138	71	dio1	dio1	PROPN
admet-2874	138	72	)	)	PUNCT
admet-2874	138	73	triiodothyronine	triiodothyronine	NOUN
admet-2874	138	74	(	(	PUNCT
admet-2874	138	75	t3	t3	PROPN
admet-2874	138	76	)	)	PUNCT
admet-2874	138	77	,	,	PUNCT
admet-2874	138	78	nuclear	nuclear	ADJ
admet-2874	138	79	thyroid	thyroid	NOUN
admet-2874	138	80	receptor	receptor	NOUN
admet-2874	138	81	β	β	X
admet-2874	138	82	(	(	PUNCT
admet-2874	138	83	thr	thr	PROPN
admet-2874	138	84	-	-	PUNCT
admet-2874	138	85	β	β	NOUN
admet-2874	138	86	)	)	PUNCT
admet-2874	138	87	,	,	PUNCT
admet-2874	138	88	retinoid	retinoid	X
admet-2874	138	89	x	x	SYM
admet-2874	138	90	receptor	receptor	NOUN
admet-2874	138	91	(	(	PUNCT
admet-2874	138	92	rxr	rxr	NOUN
admet-2874	138	93	)	)	PUNCT
admet-2874	138	94	carnitine	carnitine	NOUN
admet-2874	138	95	palmitoyltransferase	palmitoyltransferase	NOUN
admet-2874	138	96	i	i	PRON
admet-2874	138	97	(	(	PUNCT
admet-2874	138	98	cpt1	cpt1	PROPN
admet-2874	138	99	)	)	PUNCT
admet-2874	138	100	,	,	PUNCT
admet-2874	138	101	mitochondrial	mitochondrial	ADJ
admet-2874	138	102	fatty	fatty	NOUN
admet-2874	138	103	acid	acid	NOUN
admet-2874	138	104	oxidation	oxidation	NOUN
admet-2874	138	105	(	(	PUNCT
admet-2874	138	106	fao	fao	NOUN
admet-2874	138	107	)	)	PUNCT
admet-2874	138	108	,	,	PUNCT
admet-2874	138	109	and	and	CCONJ
admet-2874	138	110	sterol	sterol	NOUN
admet-2874	138	111	regulatory	regulatory	ADJ
admet-2874	138	112	element	element	NOUN
admet-2874	138	113	binding	bind	VERB
admet-2874	138	114	transcription	transcription	NOUN
admet-2874	138	115	factor	factor	NOUN
admet-2874	138	116	1	1	NUM
admet-2874	138	117	(	(	PUNCT
admet-2874	138	118	srebf1	srebf1	NOUN
admet-2874	138	119	)	)	PUNCT
admet-2874	138	120	iodothyronine	iodothyronine	ADJ
admet-2874	138	121	deiodinase	deiodinase	NOUN
admet-2874	138	122	1	1	NUM
admet-2874	138	123	(	(	PUNCT
admet-2874	138	124	dio3	dio3	PROPN
admet-2874	138	125	)	)	PUNCT
admet-2874	138	126	,	,	PUNCT
admet-2874	138	127	reverse	reverse	VERB
admet-2874	138	128	t3	t3	PROPN
admet-2874	138	129	(	(	PUNCT
admet-2874	138	130	rt3	rt3	PROPN
admet-2874	138	131	)	)	PUNCT
admet-2874	138	132	.	.	PUNCT
admet-2874	139	1	modified	modify	VERB
admet-2874	139	2	from	from	ADP
admet-2874	139	3	[	[	X
admet-2874	139	4	57	57	NUM
admet-2874	139	5	]	]	PUNCT
admet-2874	139	6	,	,	PUNCT
admet-2874	139	7	creative	creative	ADJ
admet-2874	139	8	commons	common	NOUN
admet-2874	139	9	cc	cc	X
admet-2874	139	10	by	by	ADP
admet-2874	139	11	admet	admet	PROPN
admet-2874	139	12	&	&	CCONJ
admet-2874	139	13	dmpk	dmpk	PROPN
admet-2874	139	14	13(4	13(4	NUM
admet-2874	139	15	)	)	PUNCT
admet-2874	139	16	(	(	PUNCT
admet-2874	139	17	2025	2025	NUM
admet-2874	139	18	)	)	PUNCT
admet-2874	139	19	2874	2874	NUM
admet-2874	139	20	hscs	hsc	NOUN
admet-2874	139	21	in	in	ADP
admet-2874	139	22	liver	liver	NOUN
admet-2874	139	23	fibrosis	fibrosis	NOUN
admet-2874	139	24	:	:	PUNCT
admet-2874	139	25	therapeutic	therapeutic	ADJ
admet-2874	139	26	advances	advance	NOUN
admet-2874	139	27	doi	doi	NOUN
admet-2874	139	28	:	:	PUNCT
admet-2874	139	29	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	139	30	7	7	NUM
admet-2874	139	31	figure	figure	NOUN
admet-2874	139	32	3	3	NUM
admet-2874	139	33	.	.	PUNCT
admet-2874	140	1	a	a	DET
admet-2874	140	2	targets	target	NOUN
admet-2874	140	3	of	of	ADP
admet-2874	140	4	belapectin	belapectin	NOUN
admet-2874	140	5	for	for	ADP
admet-2874	140	6	alleviation	alleviation	NOUN
admet-2874	140	7	of	of	ADP
admet-2874	140	8	fibrosis	fibrosis	NOUN
admet-2874	140	9	;	;	PUNCT
admet-2874	140	10	b	b	X
admet-2874	140	11	molecular	molecular	ADJ
admet-2874	140	12	mechanisms	mechanism	NOUN
admet-2874	140	13	of	of	ADP
admet-2874	140	14	action	action	NOUN
admet-2874	140	15	of	of	ADP
admet-2874	140	16	pirfenidone	pirfenidone	NOUN
admet-2874	140	17	.	.	PUNCT
admet-2874	141	1	it	it	PRON
admet-2874	141	2	affects	affect	VERB
admet-2874	141	3	signalling	signal	VERB
admet-2874	141	4	pathways	pathway	NOUN
admet-2874	141	5	such	such	ADJ
admet-2874	141	6	as	as	ADP
admet-2874	141	7	the	the	DET
admet-2874	141	8	smad	smad	PROPN
admet-2874	141	9	pathway	pathway	NOUN
admet-2874	141	10	,	,	PUNCT
admet-2874	141	11	which	which	PRON
admet-2874	141	12	is	be	AUX
admet-2874	141	13	downstream	downstream	ADJ
admet-2874	141	14	of	of	ADP
admet-2874	141	15	tgf	tgf	PROPN
admet-2874	141	16	-	-	PUNCT
admet-2874	141	17	β	β	PROPN
admet-2874	141	18	,	,	PUNCT
admet-2874	141	19	leading	lead	VERB
admet-2874	141	20	to	to	ADP
admet-2874	141	21	a	a	DET
admet-2874	141	22	decrease	decrease	NOUN
admet-2874	141	23	of	of	ADP
admet-2874	141	24	fibrogenic	fibrogenic	ADJ
admet-2874	141	25	activity	activity	NOUN
admet-2874	141	26	.	.	PUNCT
admet-2874	142	1	consequently	consequently	ADV
admet-2874	142	2	,	,	PUNCT
admet-2874	142	3	it	it	PRON
admet-2874	142	4	inhibits	inhibit	VERB
admet-2874	142	5	fibroblast	fibroblast	ADJ
admet-2874	142	6	proliferation	proliferation	NOUN
admet-2874	142	7	and	and	CCONJ
admet-2874	142	8	increases	increase	VERB
admet-2874	142	9	fibroblast	fibroblast	ADJ
admet-2874	142	10	apoptosis	apoptosis	NOUN
admet-2874	142	11	additionally	additionally	ADV
admet-2874	142	12	,	,	PUNCT
admet-2874	142	13	the	the	DET
admet-2874	142	14	drug	drug	NOUN
admet-2874	142	15	leads	lead	VERB
admet-2874	142	16	to	to	ADP
admet-2874	142	17	enhanced	enhanced	ADJ
admet-2874	142	18	smad	smad	PROPN
admet-2874	142	19	7	7	NUM
admet-2874	142	20	upregulation	upregulation	NOUN
admet-2874	142	21	and	and	CCONJ
admet-2874	142	22	binding	bind	VERB
admet-2874	142	23	to	to	ADP
admet-2874	142	24	tgfβri	tgfβri	NOUN
admet-2874	142	25	,	,	PUNCT
admet-2874	142	26	resulting	result	VERB
admet-2874	142	27	in	in	ADP
admet-2874	142	28	the	the	DET
admet-2874	142	29	inhibition	inhibition	NOUN
admet-2874	142	30	of	of	ADP
admet-2874	142	31	phosphorylation	phosphorylation	NOUN
admet-2874	142	32	of	of	ADP
admet-2874	142	33	profibrotic	profibrotic	ADJ
admet-2874	142	34	smad	smad	PROPN
admet-2874	142	35	2/3	2/3	NUM
admet-2874	142	36	and	and	CCONJ
admet-2874	142	37	subsequent	subsequent	ADJ
admet-2874	142	38	degradation	degradation	NOUN
admet-2874	142	39	of	of	ADP
admet-2874	142	40	tgfβri	tgfβri	NOUN
admet-2874	142	41	[	[	X
admet-2874	142	42	55	55	NUM
admet-2874	142	43	]	]	PUNCT
admet-2874	142	44	.	.	PUNCT
admet-2874	143	1	furthermore	furthermore	ADV
admet-2874	143	2	,	,	PUNCT
admet-2874	143	3	belapectin	belapectin	NOUN
admet-2874	143	4	is	be	AUX
admet-2874	143	5	a	a	DET
admet-2874	143	6	carbohydrate	carbohydrate	NOUN
admet-2874	143	7	-	-	PUNCT
admet-2874	143	8	based	base	VERB
admet-2874	143	9	drug	drug	NOUN
admet-2874	143	10	developed	develop	VERB
admet-2874	143	11	by	by	ADP
admet-2874	143	12	galectin	galectin	ADJ
admet-2874	143	13	therapeutics	therapeutic	NOUN
admet-2874	143	14	that	that	PRON
admet-2874	143	15	acts	act	VERB
admet-2874	143	16	on	on	ADP
admet-2874	143	17	the	the	DET
admet-2874	143	18	molecular	molecular	ADJ
admet-2874	143	19	level	level	NOUN
admet-2874	143	20	by	by	ADP
admet-2874	143	21	inhibiting	inhibit	VERB
admet-2874	143	22	the	the	DET
admet-2874	143	23	effects	effect	NOUN
admet-2874	143	24	of	of	ADP
admet-2874	143	25	galectin-3	galectin-3	PROPN
admet-2874	143	26	on	on	ADP
admet-2874	143	27	various	various	ADJ
admet-2874	143	28	cells	cell	NOUN
admet-2874	143	29	(	(	PUNCT
admet-2874	143	30	see	see	VERB
admet-2874	143	31	figure	figure	NOUN
admet-2874	143	32	3a	3a	NUM
admet-2874	143	33	)	)	PUNCT
admet-2874	143	34	,	,	PUNCT
admet-2874	143	35	leading	lead	VERB
admet-2874	143	36	to	to	ADP
admet-2874	143	37	reduced	reduce	VERB
admet-2874	143	38	extracellular	extracellular	ADJ
admet-2874	143	39	matrix	matrix	NOUN
admet-2874	143	40	deposition	deposition	NOUN
admet-2874	143	41	and	and	CCONJ
admet-2874	143	42	fibrosis	fibrosis	NOUN
admet-2874	143	43	development	development	NOUN
admet-2874	143	44	[	[	X
admet-2874	143	45	56	56	NUM
admet-2874	143	46	]	]	PUNCT
admet-2874	143	47	.	.	PUNCT
admet-2874	144	1	experimental	experimental	ADJ
admet-2874	144	2	approaches	approach	VERB
admet-2874	144	3	recent	recent	ADJ
admet-2874	144	4	studies	study	NOUN
admet-2874	144	5	have	have	AUX
admet-2874	144	6	demonstrated	demonstrate	VERB
admet-2874	144	7	the	the	DET
admet-2874	144	8	potential	potential	NOUN
admet-2874	144	9	for	for	ADP
admet-2874	144	10	improving	improve	VERB
admet-2874	144	11	the	the	DET
admet-2874	144	12	treatment	treatment	NOUN
admet-2874	144	13	approaches	approach	VERB
admet-2874	144	14	through	through	ADP
admet-2874	144	15	the	the	DET
admet-2874	144	16	utilization	utilization	NOUN
admet-2874	144	17	of	of	ADP
admet-2874	144	18	specific	specific	ADJ
admet-2874	144	19	targeting	targeting	NOUN
admet-2874	144	20	agents	agent	NOUN
admet-2874	144	21	and	and	CCONJ
admet-2874	144	22	ligands	ligand	NOUN
admet-2874	144	23	,	,	PUNCT
admet-2874	144	24	which	which	PRON
admet-2874	144	25	focus	focus	VERB
admet-2874	144	26	on	on	ADP
admet-2874	144	27	particular	particular	ADJ
admet-2874	144	28	markers	marker	NOUN
admet-2874	144	29	expressed	express	VERB
admet-2874	144	30	on	on	ADP
admet-2874	144	31	target	target	NOUN
admet-2874	144	32	cells	cell	NOUN
admet-2874	144	33	.	.	PUNCT
admet-2874	145	1	targeted	target	VERB
admet-2874	145	2	delivery	delivery	NOUN
admet-2874	145	3	methods	method	NOUN
admet-2874	145	4	have	have	AUX
admet-2874	145	5	demonstrated	demonstrate	VERB
admet-2874	145	6	encouraging	encourage	VERB
admet-2874	145	7	outcomes	outcome	NOUN
admet-2874	145	8	in	in	ADP
admet-2874	145	9	enhancing	enhance	VERB
admet-2874	145	10	the	the	DET
admet-2874	145	11	precision	precision	NOUN
admet-2874	145	12	and	and	CCONJ
admet-2874	145	13	effectiveness	effectiveness	NOUN
admet-2874	145	14	of	of	ADP
admet-2874	145	15	therapeutic	therapeutic	ADJ
admet-2874	145	16	approaches	approach	NOUN
admet-2874	145	17	[	[	X
admet-2874	145	18	75	75	NUM
admet-2874	145	19	]	]	PUNCT
admet-2874	145	20	.	.	PUNCT
admet-2874	146	1	the	the	DET
admet-2874	146	2	receptors	receptor	NOUN
admet-2874	146	3	playing	play	VERB
admet-2874	146	4	an	an	DET
admet-2874	146	5	important	important	ADJ
admet-2874	146	6	role	role	NOUN
admet-2874	146	7	in	in	ADP
admet-2874	146	8	liver	liver	NOUN
admet-2874	146	9	fibrosis	fibrosis	NOUN
admet-2874	146	10	and	and	CCONJ
admet-2874	146	11	emerged	emerge	VERB
admet-2874	146	12	as	as	ADP
admet-2874	146	13	potential	potential	ADJ
admet-2874	146	14	targets	target	NOUN
admet-2874	146	15	for	for	ADP
admet-2874	146	16	the	the	DET
admet-2874	146	17	therapy	therapy	NOUN
admet-2874	146	18	of	of	ADP
admet-2874	146	19	liver	liver	NOUN
admet-2874	146	20	fibrosis	fibrosis	NOUN
admet-2874	146	21	include	include	VERB
admet-2874	146	22	nuclear	nuclear	ADJ
admet-2874	146	23	receptors	receptor	NOUN
admet-2874	146	24	,	,	PUNCT
admet-2874	146	25	i.e.	i.e.	X
admet-2874	146	26	liver	liver	NOUN
admet-2874	146	27	x	x	NOUN
admet-2874	146	28	receptors	receptor	NOUN
admet-2874	146	29	(	(	PUNCT
admet-2874	146	30	lxr	lxr	PROPN
admet-2874	146	31	)	)	PUNCT
admet-2874	146	32	,	,	PUNCT
admet-2874	146	33	farnesoid	farnesoid	ADJ
admet-2874	146	34	x	x	X
admet-2874	146	35	receptor	receptor	NOUN
admet-2874	146	36	(	(	PUNCT
admet-2874	146	37	fxr	fxr	NOUN
admet-2874	146	38	)	)	PUNCT
admet-2874	146	39	,	,	PUNCT
admet-2874	146	40	retinoid	retinoid	X
admet-2874	146	41	x	x	SYM
admet-2874	146	42	receptor	receptor	NOUN
admet-2874	146	43	(	(	PUNCT
admet-2874	146	44	rxr	rxr	PROPN
admet-2874	146	45	)	)	PUNCT
admet-2874	146	46	,	,	PUNCT
admet-2874	146	47	vitamin	vitamin	NOUN
admet-2874	146	48	d	d	NOUN
admet-2874	146	49	receptor	receptor	NOUN
admet-2874	146	50	(	(	PUNCT
admet-2874	146	51	vdr	vdr	NOUN
admet-2874	146	52	)	)	PUNCT
admet-2874	146	53	,	,	PUNCT
admet-2874	146	54	cannabinoid	cannabinoid	NOUN
admet-2874	146	55	receptors	receptor	NOUN
admet-2874	146	56	,	,	PUNCT
admet-2874	146	57	toll	toll	NOUN
admet-2874	146	58	-	-	PUNCT
admet-2874	146	59	like	like	ADJ
admet-2874	146	60	receptor	receptor	NOUN
admet-2874	146	61	(	(	PUNCT
admet-2874	146	62	tlr	tlr	PROPN
admet-2874	146	63	)	)	PUNCT
admet-2874	146	64	,	,	PUNCT
admet-2874	146	65	and	and	CCONJ
admet-2874	146	66	peroxisome	peroxisome	VERB
admet-2874	146	67	proliferator	proliferator	NOUN
admet-2874	146	68	-	-	PUNCT
admet-2874	146	69	activated	activate	VERB
admet-2874	146	70	receptors	receptor	NOUN
admet-2874	146	71	(	(	PUNCT
admet-2874	146	72	ppars	ppar	NOUN
admet-2874	146	73	)	)	PUNCT
admet-2874	146	74	(	(	PUNCT
admet-2874	146	75	see	see	VERB
admet-2874	146	76	table	table	NOUN
admet-2874	146	77	2	2	NUM
admet-2874	146	78	)	)	PUNCT
admet-2874	146	79	.	.	PUNCT
admet-2874	147	1	lxr	lxr	PROPN
admet-2874	147	2	belongs	belong	VERB
admet-2874	147	3	to	to	ADP
admet-2874	147	4	the	the	DET
admet-2874	147	5	family	family	NOUN
admet-2874	147	6	of	of	ADP
admet-2874	147	7	nuclear	nuclear	ADJ
admet-2874	147	8	receptors	receptor	NOUN
admet-2874	147	9	and	and	CCONJ
admet-2874	147	10	regulates	regulate	VERB
admet-2874	147	11	the	the	DET
admet-2874	147	12	accumulation	accumulation	NOUN
admet-2874	147	13	of	of	ADP
admet-2874	147	14	fat	fat	NOUN
admet-2874	147	15	,	,	PUNCT
admet-2874	147	16	the	the	DET
admet-2874	147	17	level	level	NOUN
admet-2874	147	18	of	of	ADP
admet-2874	147	19	inflammation	inflammation	NOUN
admet-2874	147	20	,	,	PUNCT
admet-2874	147	21	and	and	CCONJ
admet-2874	147	22	scarring	scarring	NOUN
admet-2874	147	23	of	of	ADP
admet-2874	147	24	liver	liver	NOUN
admet-2874	147	25	tissue	tissue	NOUN
admet-2874	147	26	with	with	ADP
admet-2874	147	27	fibrosis	fibrosis	NOUN
admet-2874	147	28	in	in	ADP
admet-2874	147	29	nafld	nafld	PROPN
admet-2874	147	30	.	.	PUNCT
admet-2874	148	1	lxrα	lxrα	ADJ
admet-2874	148	2	expression	expression	NOUN
admet-2874	148	3	was	be	AUX
admet-2874	148	4	positively	positively	ADV
admet-2874	148	5	correlated	correlate	VERB
admet-2874	148	6	with	with	ADP
admet-2874	148	7	intrahepatic	intrahepatic	ADJ
admet-2874	148	8	expression	expression	NOUN
admet-2874	148	9	of	of	ADP
admet-2874	148	10	cd36	cd36	PROPN
admet-2874	148	11	,	,	PUNCT
admet-2874	148	12	srebp-1c	srebp-1c	ADJ
admet-2874	148	13	,	,	PUNCT
admet-2874	148	14	and	and	CCONJ
admet-2874	148	15	abcg5/8	abcg5/8	NOUN
admet-2874	148	16	.	.	PUNCT
admet-2874	149	1	they	they	PRON
admet-2874	149	2	demonstrated	demonstrate	VERB
admet-2874	149	3	that	that	SCONJ
admet-2874	149	4	lxr	lxr	PROPN
admet-2874	149	5	is	be	AUX
admet-2874	149	6	an	an	DET
admet-2874	149	7	attractive	attractive	ADJ
admet-2874	149	8	therapeutic	therapeutic	ADJ
admet-2874	149	9	target	target	NOUN
admet-2874	149	10	for	for	ADP
admet-2874	149	11	liver	liver	NOUN
admet-2874	149	12	fibrosis	fibrosis	NOUN
admet-2874	149	13	.	.	PUNCT
admet-2874	150	1	gw3965	gw3965	PROPN
admet-2874	150	2	is	be	AUX
admet-2874	150	3	an	an	DET
admet-2874	150	4	agonist	agonist	NOUN
admet-2874	150	5	of	of	ADP
admet-2874	150	6	lxr	lxr	NOUN
admet-2874	150	7	and	and	CCONJ
admet-2874	150	8	reduces	reduce	VERB
admet-2874	150	9	signs	sign	NOUN
admet-2874	150	10	of	of	ADP
admet-2874	150	11	scarring	scarring	NOUN
admet-2874	150	12	and	and	CCONJ
admet-2874	150	13	inflammation	inflammation	NOUN
admet-2874	150	14	,	,	PUNCT
admet-2874	150	15	as	as	ADV
admet-2874	150	16	well	well	ADV
admet-2874	150	17	as	as	ADP
admet-2874	150	18	the	the	DET
admet-2874	150	19	activation	activation	NOUN
admet-2874	150	20	of	of	ADP
admet-2874	150	21	hepatic	hepatic	ADJ
admet-2874	150	22	stellate	stellate	ADJ
admet-2874	150	23	cells	cell	NOUN
admet-2874	150	24	in	in	ADP
admet-2874	150	25	mice	mouse	NOUN
admet-2874	150	26	[	[	X
admet-2874	150	27	76	76	NUM
admet-2874	150	28	]	]	PUNCT
admet-2874	150	29	.	.	PUNCT
admet-2874	151	1	fxr	fxr	PROPN
admet-2874	151	2	is	be	AUX
admet-2874	151	3	a	a	DET
admet-2874	151	4	bile	bile	NOUN
admet-2874	151	5	acid	acid	NOUN
admet-2874	151	6	-	-	PUNCT
admet-2874	151	7	activated	activate	VERB
admet-2874	151	8	nuclear	nuclear	ADJ
admet-2874	151	9	receptor	receptor	NOUN
admet-2874	151	10	,	,	PUNCT
admet-2874	151	11	also	also	ADV
admet-2874	151	12	known	know	VERB
admet-2874	151	13	as	as	ADP
admet-2874	151	14	nr1h4	nr1h4	PROPN
admet-2874	151	15	.	.	PUNCT
admet-2874	152	1	fxr	fxr	PROPN
admet-2874	152	2	contributes	contribute	VERB
admet-2874	152	3	to	to	ADP
admet-2874	152	4	preventing	prevent	VERB
admet-2874	152	5	hsc	hsc	NOUN
admet-2874	152	6	activation	activation	NOUN
admet-2874	152	7	and	and	CCONJ
admet-2874	152	8	retaining	retain	VERB
admet-2874	152	9	their	their	PRON
admet-2874	152	10	quiescent	quiescent	ADJ
admet-2874	152	11	state	state	NOUN
admet-2874	152	12	.	.	PUNCT
admet-2874	153	1	fxr	fxr	PROPN
admet-2874	153	2	lowers	lower	VERB
admet-2874	153	3	the	the	DET
admet-2874	153	4	risk	risk	NOUN
admet-2874	153	5	of	of	ADP
admet-2874	153	6	bile	bile	NOUN
admet-2874	153	7	acid	acid	NOUN
admet-2874	153	8	-	-	PUNCT
admet-2874	153	9	induced	induce	VERB
admet-2874	153	10	liver	liver	NOUN
admet-2874	153	11	damage	damage	NOUN
admet-2874	153	12	by	by	ADP
admet-2874	153	13	controlling	control	VERB
admet-2874	153	14	the	the	DET
admet-2874	153	15	expression	expression	NOUN
admet-2874	153	16	of	of	ADP
admet-2874	153	17	genes	gene	NOUN
admet-2874	153	18	related	relate	VERB
admet-2874	153	19	to	to	AUX
admet-2874	153	20	bile	bile	VERB
admet-2874	153	21	acid	acid	NOUN
admet-2874	153	22	metabolism	metabolism	NOUN
admet-2874	153	23	.	.	PUNCT
admet-2874	154	1	fxr	fxr	PROPN
admet-2874	154	2	maintains	maintain	VERB
admet-2874	154	3	quiescent	quiescent	ADJ
admet-2874	154	4	hscs	hsc	NOUN
admet-2874	154	5	and	and	CCONJ
admet-2874	154	6	controls	control	VERB
admet-2874	154	7	bile	bile	NOUN
admet-2874	154	8	acid	acid	NOUN
admet-2874	154	9	levels	level	NOUN
admet-2874	154	10	,	,	PUNCT
admet-2874	154	11	so	so	SCONJ
admet-2874	154	12	it	it	PRON
admet-2874	154	13	plays	play	VERB
admet-2874	154	14	an	an	DET
admet-2874	154	15	important	important	ADJ
admet-2874	154	16	role	role	NOUN
admet-2874	154	17	in	in	ADP
admet-2874	154	18	controlling	control	VERB
admet-2874	154	19	liver	liver	NOUN
admet-2874	154	20	fibrosis	fibrosis	NOUN
admet-2874	155	1	[	[	X
admet-2874	155	2	77,78	77,78	PROPN
admet-2874	155	3	]	]	PUNCT
admet-2874	155	4	.	.	PUNCT
admet-2874	156	1	rxr	rxr	PROPN
admet-2874	156	2	is	be	AUX
admet-2874	156	3	involved	involve	VERB
admet-2874	156	4	in	in	ADP
admet-2874	156	5	several	several	ADJ
admet-2874	156	6	biological	biological	ADJ
admet-2874	156	7	processes	process	NOUN
admet-2874	156	8	,	,	PUNCT
admet-2874	156	9	including	include	VERB
admet-2874	156	10	the	the	DET
admet-2874	156	11	regulation	regulation	NOUN
admet-2874	156	12	of	of	ADP
admet-2874	156	13	transcription	transcription	NOUN
admet-2874	156	14	factors	factor	NOUN
admet-2874	156	15	and	and	CCONJ
admet-2874	156	16	gene	gene	NOUN
admet-2874	156	17	expression	expression	NOUN
admet-2874	156	18	.	.	PUNCT
admet-2874	157	1	rxr	rxr	PROPN
admet-2874	157	2	-	-	PUNCT
admet-2874	157	3	α	α	PROPN
admet-2874	157	4	,	,	PUNCT
admet-2874	157	5	rxr	rxr	PROPN
admet-2874	157	6	-	-	PUNCT
admet-2874	157	7	β	β	PROPN
admet-2874	157	8	,	,	PUNCT
admet-2874	157	9	and	and	CCONJ
admet-2874	157	10	rxr	rxr	NOUN
admet-2874	157	11	-	-	PUNCT
admet-2874	157	12	γ	γ	NOUN
admet-2874	157	13	are	be	AUX
admet-2874	157	14	the	the	DET
admet-2874	157	15	three	three	NUM
admet-2874	157	16	main	main	ADJ
admet-2874	157	17	types	type	NOUN
admet-2874	157	18	of	of	ADP
admet-2874	157	19	retinoid	retinoid	NOUN
admet-2874	157	20	x	x	SYM
admet-2874	157	21	receptor	receptor	NOUN
admet-2874	157	22	.	.	PUNCT
admet-2874	158	1	ligands	ligand	NOUN
admet-2874	158	2	activate	activate	VERB
admet-2874	158	3	rxrs	rxrs	NOUN
admet-2874	158	4	,	,	PUNCT
admet-2874	158	5	like	like	ADP
admet-2874	158	6	9	9	NUM
admet-2874	158	7	-	-	PUNCT
admet-2874	158	8	cis	cis	NOUN
admet-2874	158	9	retinoic	retinoic	NOUN
admet-2874	158	10	acid	acid	NOUN
admet-2874	158	11	,	,	PUNCT
admet-2874	158	12	after	after	SCONJ
admet-2874	158	13	activation	activation	NOUN
admet-2874	158	14	modulates	modulate	VERB
admet-2874	158	15	transcription	transcription	NOUN
admet-2874	158	16	of	of	ADP
admet-2874	158	17	genes	gene	NOUN
admet-2874	158	18	that	that	PRON
admet-2874	158	19	control	control	VERB
admet-2874	158	20	cell	cell	NOUN
admet-2874	158	21	proliferation	proliferation	NOUN
admet-2874	158	22	,	,	PUNCT
admet-2874	158	23	differentiation	differentiation	NOUN
admet-2874	158	24	,	,	PUNCT
admet-2874	158	25	and	and	CCONJ
admet-2874	158	26	death	death	NOUN
admet-2874	158	27	,	,	PUNCT
admet-2874	158	28	as	as	ADV
admet-2874	158	29	well	well	ADV
admet-2874	158	30	as	as	ADP
admet-2874	158	31	maintain	maintain	VERB
admet-2874	158	32	hscs	hsc	NOUN
admet-2874	158	33	in	in	ADP
admet-2874	158	34	their	their	PRON
admet-2874	158	35	quiescent	quiescent	ADJ
admet-2874	158	36	state	state	NOUN
admet-2874	158	37	.	.	PUNCT
admet-2874	159	1	also	also	ADV
admet-2874	159	2	,	,	PUNCT
admet-2874	159	3	it	it	PRON
admet-2874	159	4	has	have	AUX
admet-2874	159	5	been	be	AUX
admet-2874	159	6	reported	report	VERB
admet-2874	159	7	that	that	SCONJ
admet-2874	159	8	vitamin	vitamin	NOUN
admet-2874	159	9	a	a	DET
admet-2874	159	10	(	(	PUNCT
admet-2874	159	11	va	va	NOUN
admet-2874	159	12	)	)	PUNCT
admet-2874	159	13	decorated	decorate	VERB
admet-2874	159	14	valsartan	valsartan	PROPN
admet-2874	159	15	-	-	PUNCT
admet-2874	159	16	loaded	load	VERB
admet-2874	159	17	liposome	liposome	NOUN
admet-2874	159	18	therapy	therapy	NOUN
admet-2874	159	19	(	(	PUNCT
admet-2874	159	20	vlc	vlc	PROPN
admet-2874	159	21	)	)	PUNCT
admet-2874	159	22	leads	lead	VERB
admet-2874	159	23	to	to	ADP
admet-2874	159	24	the	the	DET
admet-2874	159	25	re	re	NOUN
admet-2874	159	26	-	-	NOUN
admet-2874	159	27	expression	expression	NOUN
admet-2874	159	28	of	of	ADP
admet-2874	159	29	ppar	ppar	NOUN
admet-2874	159	30	-	-	PUNCT
admet-2874	159	31	γ	γ	NOUN
admet-2874	159	32	,	,	PUNCT
admet-2874	159	33	with	with	ADP
admet-2874	159	34	a	a	DET
admet-2874	159	35	significant	significant	ADJ
admet-2874	159	36	reduction	reduction	NOUN
admet-2874	159	37	in	in	ADP
admet-2874	159	38	fibrogenic	fibrogenic	ADJ
admet-2874	159	39	mediators	mediator	NOUN
admet-2874	159	40	,	,	PUNCT
admet-2874	159	41	and	and	CCONJ
admet-2874	159	42	nearly	nearly	ADV
admet-2874	159	43	normalized	normalize	VERB
admet-2874	159	44	liver	liver	NOUN
admet-2874	159	45	function	function	NOUN
admet-2874	159	46	tests	test	NOUN
admet-2874	159	47	.	.	PUNCT
admet-2874	160	1	these	these	DET
admet-2874	160	2	liposomes	liposome	NOUN
admet-2874	160	3	were	be	AUX
admet-2874	160	4	coupled	couple	VERB
admet-2874	160	5	with	with	ADP
admet-2874	160	6	va	va	NOUN
admet-2874	160	7	to	to	PART
admet-2874	160	8	specifically	specifically	ADV
admet-2874	160	9	target	target	VERB
admet-2874	160	10	hscs	hsc	NOUN
admet-2874	160	11	[	[	X
admet-2874	160	12	79,80	79,80	NOUN
admet-2874	160	13	]	]	PUNCT
admet-2874	160	14	.	.	PUNCT
admet-2874	161	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	161	2	a.	a.	PROPN
admet-2874	161	3	singh	singh	PROPN
admet-2874	161	4	et	et	PROPN
admet-2874	161	5	al	al	PROPN
admet-2874	161	6	.	.	PROPN
admet-2874	161	7	admet	admet	PROPN
admet-2874	161	8	&	&	CCONJ
admet-2874	161	9	dmpk	dmpk	PROPN
admet-2874	161	10	13(4	13(4	NUM
admet-2874	161	11	)	)	PUNCT
admet-2874	161	12	(	(	PUNCT
admet-2874	161	13	2025	2025	NUM
admet-2874	161	14	)	)	PUNCT
admet-2874	161	15	2874	2874	NUM
admet-2874	161	16	8	8	NUM
admet-2874	161	17	cannabinoid	cannabinoid	NOUN
admet-2874	161	18	receptors	receptor	NOUN
admet-2874	161	19	(	(	PUNCT
admet-2874	161	20	g	g	NOUN
admet-2874	161	21	protein	protein	NOUN
admet-2874	161	22	-	-	PUNCT
admet-2874	161	23	coupled	couple	VERB
admet-2874	161	24	receptors	receptor	NOUN
admet-2874	161	25	)	)	PUNCT
admet-2874	161	26	are	be	AUX
admet-2874	161	27	part	part	NOUN
admet-2874	161	28	of	of	ADP
admet-2874	161	29	the	the	DET
admet-2874	161	30	endocannabinoid	endocannabinoid	NOUN
admet-2874	161	31	system	system	NOUN
admet-2874	161	32	,	,	PUNCT
admet-2874	161	33	having	have	VERB
admet-2874	161	34	two	two	NUM
admet-2874	161	35	subtypes	subtype	NOUN
admet-2874	161	36	,	,	PUNCT
admet-2874	161	37	namely	namely	ADV
admet-2874	161	38	cbr1	cbr1	PROPN
admet-2874	161	39	(	(	PUNCT
admet-2874	161	40	present	present	ADJ
admet-2874	161	41	in	in	ADP
admet-2874	161	42	hepatocytes	hepatocyte	NOUN
admet-2874	161	43	)	)	PUNCT
admet-2874	161	44	and	and	CCONJ
admet-2874	161	45	cbr2	cbr2	NOUN
admet-2874	161	46	(	(	PUNCT
admet-2874	161	47	immune	immune	ADJ
admet-2874	161	48	cells	cell	NOUN
admet-2874	161	49	present	present	ADJ
admet-2874	161	50	in	in	ADP
admet-2874	161	51	the	the	DET
admet-2874	161	52	liver	liver	NOUN
admet-2874	161	53	)	)	PUNCT
admet-2874	161	54	.	.	PUNCT
admet-2874	162	1	activation	activation	NOUN
admet-2874	162	2	of	of	ADP
admet-2874	162	3	cbr1	cbr1	PROPN
admet-2874	162	4	has	have	AUX
admet-2874	162	5	been	be	AUX
admet-2874	162	6	associated	associate	VERB
admet-2874	162	7	with	with	ADP
admet-2874	162	8	lipid	lipid	ADJ
admet-2874	162	9	accumulation	accumulation	NOUN
admet-2874	162	10	in	in	ADP
admet-2874	162	11	hepatocytes	hepatocyte	NOUN
admet-2874	162	12	,	,	PUNCT
admet-2874	162	13	leading	lead	VERB
admet-2874	162	14	to	to	ADP
admet-2874	162	15	liver	liver	NOUN
admet-2874	162	16	fibrosis	fibrosis	NOUN
admet-2874	162	17	[	[	X
admet-2874	162	18	81	81	NUM
admet-2874	162	19	]	]	PUNCT
admet-2874	162	20	.	.	PUNCT
admet-2874	163	1	cbr2	cbr2	NOUN
admet-2874	163	2	displays	display	VERB
admet-2874	163	3	protective	protective	ADJ
admet-2874	163	4	behaviour	behaviour	NOUN
admet-2874	163	5	against	against	ADP
admet-2874	163	6	liver	liver	NOUN
admet-2874	163	7	fibrosis	fibrosis	NOUN
admet-2874	163	8	through	through	ADP
admet-2874	163	9	reducing	reduce	VERB
admet-2874	163	10	inflammation	inflammation	NOUN
admet-2874	163	11	and	and	CCONJ
admet-2874	163	12	regulating	regulate	VERB
admet-2874	163	13	immune	immune	ADJ
admet-2874	163	14	response	response	NOUN
admet-2874	163	15	[	[	X
admet-2874	163	16	82	82	NUM
admet-2874	163	17	]	]	PUNCT
admet-2874	163	18	.	.	PUNCT
admet-2874	164	1	likewise	likewise	ADV
admet-2874	164	2	,	,	PUNCT
admet-2874	164	3	toll	toll	NOUN
admet-2874	164	4	-	-	PUNCT
admet-2874	164	5	like	like	ADJ
admet-2874	164	6	receptors	receptor	NOUN
admet-2874	164	7	are	be	AUX
admet-2874	164	8	a	a	DET
admet-2874	164	9	class	class	NOUN
admet-2874	164	10	of	of	ADP
admet-2874	164	11	proteins	protein	NOUN
admet-2874	164	12	that	that	PRON
admet-2874	164	13	control	control	VERB
admet-2874	164	14	the	the	DET
admet-2874	164	15	activity	activity	NOUN
admet-2874	164	16	of	of	ADP
admet-2874	164	17	the	the	DET
admet-2874	164	18	innate	innate	ADJ
admet-2874	164	19	immune	immune	ADJ
admet-2874	164	20	system	system	NOUN
admet-2874	164	21	.	.	PUNCT
admet-2874	165	1	by	by	ADP
admet-2874	165	2	focusing	focus	VERB
admet-2874	165	3	on	on	ADP
admet-2874	165	4	pathogen	pathogen	NOUN
admet-2874	165	5	-	-	PUNCT
admet-2874	165	6	associated	associate	VERB
admet-2874	165	7	molecular	molecular	ADJ
admet-2874	165	8	patterns	pattern	NOUN
admet-2874	165	9	(	(	PUNCT
admet-2874	165	10	pamps	pamp	NOUN
admet-2874	165	11	)	)	PUNCT
admet-2874	165	12	and	and	CCONJ
admet-2874	165	13	damage	damage	NOUN
admet-2874	165	14	-	-	PUNCT
admet-2874	165	15	associated	associate	VERB
admet-2874	165	16	molecular	molecular	ADJ
admet-2874	165	17	patterns	pattern	NOUN
admet-2874	165	18	(	(	PUNCT
admet-2874	165	19	damps	damps	PROPN
admet-2874	165	20	)	)	PUNCT
admet-2874	165	21	,	,	PUNCT
admet-2874	165	22	they	they	PRON
admet-2874	165	23	elicit	elicit	VERB
admet-2874	165	24	an	an	DET
admet-2874	165	25	immune	immune	ADJ
admet-2874	165	26	response	response	NOUN
admet-2874	165	27	.	.	PUNCT
admet-2874	166	1	in	in	ADP
admet-2874	166	2	this	this	DET
admet-2874	166	3	context	context	NOUN
admet-2874	166	4	,	,	PUNCT
admet-2874	166	5	it	it	PRON
admet-2874	166	6	has	have	AUX
admet-2874	166	7	been	be	AUX
admet-2874	166	8	observed	observe	VERB
admet-2874	166	9	that	that	SCONJ
admet-2874	166	10	hscs	hscs	ADJ
admet-2874	166	11	activation	activation	NOUN
admet-2874	166	12	also	also	ADV
admet-2874	166	13	gets	get	AUX
admet-2874	166	14	upregulated	upregulate	VERB
admet-2874	166	15	by	by	ADP
admet-2874	166	16	tlr4	tlr4	NOUN
admet-2874	166	17	signalling	signal	VERB
admet-2874	166	18	and	and	CCONJ
admet-2874	166	19	promotes	promote	VERB
admet-2874	166	20	fibrosis	fibrosis	NOUN
admet-2874	166	21	by	by	ADP
admet-2874	166	22	releasing	release	VERB
admet-2874	166	23	profibrotic	profibrotic	ADJ
admet-2874	166	24	factors	factor	NOUN
admet-2874	166	25	and	and	CCONJ
admet-2874	166	26	pro	pro	ADJ
admet-2874	166	27	-	-	ADJ
admet-2874	166	28	inflammatory	inflammatory	ADJ
admet-2874	166	29	cytokines	cytokine	NOUN
admet-2874	166	30	[	[	X
admet-2874	166	31	83	83	NUM
admet-2874	166	32	]	]	PUNCT
admet-2874	166	33	.	.	PUNCT
admet-2874	167	1	scientists	scientist	NOUN
admet-2874	167	2	also	also	ADV
admet-2874	167	3	reported	report	VERB
admet-2874	167	4	[	[	X
admet-2874	167	5	84	84	NUM
admet-2874	167	6	]	]	PUNCT
admet-2874	167	7	that	that	SCONJ
admet-2874	167	8	controlling	control	VERB
admet-2874	167	9	tlr	tlr	PROPN
admet-2874	167	10	signalling	signal	VERB
admet-2874	167	11	is	be	AUX
admet-2874	167	12	a	a	DET
admet-2874	167	13	potential	potential	ADJ
admet-2874	167	14	therapeutic	therapeutic	ADJ
admet-2874	167	15	approach	approach	NOUN
admet-2874	167	16	for	for	ADP
admet-2874	167	17	preventing	prevent	VERB
admet-2874	167	18	the	the	DET
admet-2874	167	19	development	development	NOUN
admet-2874	167	20	of	of	ADP
admet-2874	167	21	liver	liver	NOUN
admet-2874	167	22	fibrosis	fibrosis	NOUN
admet-2874	167	23	.	.	PUNCT
admet-2874	168	1	alt-100	alt-100	PROPN
admet-2874	168	2	,	,	PUNCT
admet-2874	168	3	a	a	DET
admet-2874	168	4	monoclonal	monoclonal	NOUN
admet-2874	168	5	antibody	antibody	NOUN
admet-2874	168	6	that	that	PRON
admet-2874	168	7	neutralizes	neutralize	VERB
admet-2874	168	8	enampt	enampt	ADJ
admet-2874	168	9	,	,	PUNCT
admet-2874	168	10	significantly	significantly	ADV
admet-2874	168	11	reduces	reduce	VERB
admet-2874	168	12	nafld	nafld	ADJ
admet-2874	168	13	severity	severity	NOUN
admet-2874	168	14	and	and	CCONJ
admet-2874	168	15	progression	progression	NOUN
admet-2874	168	16	to	to	ADP
admet-2874	168	17	nash	nash	NOUN
admet-2874	168	18	/	/	SYM
admet-2874	168	19	hepatic	hepatic	NOUN
admet-2874	168	20	fibrosis	fibrosis	NOUN
admet-2874	168	21	by	by	ADP
admet-2874	168	22	attenuating	attenuate	VERB
admet-2874	168	23	liver	liver	NOUN
admet-2874	168	24	inflamemation	inflamemation	NOUN
admet-2874	168	25	,	,	PUNCT
admet-2874	168	26	triglyceride	triglyceride	ADP
admet-2874	168	27	accumulation	accumulation	NOUN
admet-2874	168	28	,	,	PUNCT
admet-2874	168	29	and	and	CCONJ
admet-2874	168	30	fibrosis	fibrosis	NOUN
admet-2874	168	31	in	in	ADP
admet-2874	168	32	both	both	CCONJ
admet-2874	168	33	human	human	ADJ
admet-2874	168	34	and	and	CCONJ
admet-2874	168	35	mouse	mouse	NOUN
admet-2874	168	36	models	model	NOUN
admet-2874	168	37	.	.	PUNCT
admet-2874	169	1	these	these	DET
admet-2874	169	2	results	result	NOUN
admet-2874	169	3	suggested	suggest	VERB
admet-2874	169	4	that	that	SCONJ
admet-2874	169	5	targeting	target	VERB
admet-2874	169	6	the	the	DET
admet-2874	169	7	enampt	enampt	ADJ
admet-2874	169	8	/	/	SYM
admet-2874	169	9	tlr4	tlr4	NOUN
admet-2874	169	10	pathway	pathway	NOUN
admet-2874	169	11	could	could	AUX
admet-2874	169	12	be	be	AUX
admet-2874	169	13	a	a	DET
admet-2874	169	14	promising	promising	ADJ
admet-2874	169	15	therapeutic	therapeutic	ADJ
admet-2874	169	16	strategy	strategy	NOUN
admet-2874	169	17	for	for	ADP
admet-2874	169	18	nafld	nafld	ADJ
admet-2874	170	1	[	[	X
admet-2874	170	2	84	84	NUM
admet-2874	170	3	]	]	PUNCT
admet-2874	170	4	.	.	PUNCT
admet-2874	171	1	furthermore	furthermore	ADV
admet-2874	171	2	,	,	PUNCT
admet-2874	171	3	ppars	ppar	NOUN
admet-2874	171	4	(	(	PUNCT
admet-2874	171	5	subtypes	subtype	NOUN
admet-2874	171	6	:	:	PUNCT
admet-2874	171	7	pparα	pparα	NOUN
admet-2874	171	8	,	,	PUNCT
admet-2874	171	9	pparβ	pparβ	NOUN
admet-2874	171	10	/	/	SYM
admet-2874	171	11	δ	δ	PROPN
admet-2874	171	12	,	,	PUNCT
admet-2874	171	13	and	and	CCONJ
admet-2874	171	14	pparγ	pparγ	ADJ
admet-2874	171	15	)	)	PUNCT
admet-2874	171	16	agonists	agonist	NOUN
admet-2874	171	17	have	have	AUX
admet-2874	171	18	emerged	emerge	VERB
admet-2874	171	19	as	as	ADP
admet-2874	171	20	an	an	DET
admet-2874	171	21	important	important	ADJ
admet-2874	171	22	therapeutic	therapeutic	ADJ
admet-2874	171	23	option	option	NOUN
admet-2874	171	24	for	for	ADP
admet-2874	171	25	liver	liver	NOUN
admet-2874	171	26	and	and	CCONJ
admet-2874	171	27	other	other	ADJ
admet-2874	171	28	metabolic	metabolic	NOUN
admet-2874	171	29	disorders	disorder	NOUN
admet-2874	171	30	by	by	ADP
admet-2874	171	31	boosting	boost	VERB
admet-2874	171	32	antioxidant	antioxidant	ADJ
admet-2874	171	33	factors	factor	NOUN
admet-2874	171	34	and	and	CCONJ
admet-2874	171	35	reducing	reduce	VERB
admet-2874	171	36	inflammation	inflammation	NOUN
admet-2874	171	37	.	.	PUNCT
admet-2874	172	1	pparα	pparα	PROPN
admet-2874	172	2	,	,	PUNCT
admet-2874	172	3	which	which	PRON
admet-2874	172	4	regulates	regulate	VERB
admet-2874	172	5	lipid	lipid	ADJ
admet-2874	172	6	metabolism	metabolism	NOUN
admet-2874	172	7	and	and	CCONJ
admet-2874	172	8	inflammation	inflammation	NOUN
admet-2874	172	9	and	and	CCONJ
admet-2874	172	10	has	have	VERB
admet-2874	172	11	an	an	DET
admet-2874	172	12	indirect	indirect	ADJ
admet-2874	172	13	role	role	NOUN
admet-2874	172	14	in	in	ADP
admet-2874	172	15	the	the	DET
admet-2874	172	16	activation	activation	NOUN
admet-2874	172	17	of	of	ADP
admet-2874	172	18	hscs	hsc	NOUN
admet-2874	172	19	,	,	PUNCT
admet-2874	172	20	is	be	AUX
admet-2874	172	21	an	an	DET
admet-2874	172	22	important	important	ADJ
admet-2874	172	23	target	target	NOUN
admet-2874	172	24	for	for	ADP
admet-2874	172	25	preventing	prevent	VERB
admet-2874	172	26	the	the	DET
admet-2874	172	27	progression	progression	NOUN
admet-2874	172	28	of	of	ADP
admet-2874	172	29	liver	liver	NOUN
admet-2874	172	30	fibrosis	fibrosis	NOUN
admet-2874	172	31	.	.	PUNCT
admet-2874	173	1	pparγ	pparγ	PROPN
admet-2874	173	2	is	be	AUX
admet-2874	173	3	important	important	ADJ
admet-2874	173	4	in	in	ADP
admet-2874	173	5	reducing	reduce	VERB
admet-2874	173	6	liver	liver	NOUN
admet-2874	173	7	fibrosis	fibrosis	NOUN
admet-2874	173	8	because	because	SCONJ
admet-2874	173	9	it	it	PRON
admet-2874	173	10	has	have	VERB
admet-2874	173	11	the	the	DET
admet-2874	173	12	potential	potential	NOUN
admet-2874	173	13	to	to	PART
admet-2874	173	14	inhibit	inhibit	VERB
admet-2874	173	15	the	the	DET
admet-2874	173	16	activation	activation	NOUN
admet-2874	173	17	of	of	ADP
admet-2874	173	18	hepatic	hepatic	ADJ
admet-2874	173	19	stellate	stellate	ADJ
admet-2874	173	20	cells	cell	NOUN
admet-2874	173	21	,	,	PUNCT
admet-2874	173	22	regulate	regulate	VERB
admet-2874	173	23	lipid	lipid	ADJ
admet-2874	173	24	metabolism	metabolism	NOUN
admet-2874	173	25	,	,	PUNCT
admet-2874	173	26	and	and	CCONJ
admet-2874	173	27	reduce	reduce	VERB
admet-2874	173	28	inflammation	inflammation	NOUN
admet-2874	173	29	and	and	CCONJ
admet-2874	173	30	tumour	tumour	NOUN
admet-2874	173	31	growth	growth	NOUN
admet-2874	173	32	in	in	ADP
admet-2874	173	33	the	the	DET
admet-2874	173	34	liver	liver	NOUN
admet-2874	173	35	.	.	PUNCT
admet-2874	174	1	on	on	ADP
admet-2874	174	2	the	the	DET
admet-2874	174	3	other	other	ADJ
admet-2874	174	4	hand	hand	NOUN
admet-2874	174	5	,	,	PUNCT
admet-2874	174	6	the	the	DET
admet-2874	174	7	role	role	NOUN
admet-2874	174	8	of	of	ADP
admet-2874	174	9	pparβ	pparβ	NOUN
admet-2874	174	10	/	/	SYM
admet-2874	174	11	δ	δ	PROPN
admet-2874	174	12	in	in	ADP
admet-2874	174	13	preventing	prevent	VERB
admet-2874	174	14	liver	liver	NOUN
admet-2874	174	15	fibrosis	fibrosis	NOUN
admet-2874	174	16	was	be	AUX
admet-2874	174	17	demonstrated	demonstrate	VERB
admet-2874	174	18	by	by	ADP
admet-2874	174	19	zang	zang	PROPN
admet-2874	174	20	et	et	PROPN
admet-2874	174	21	al	al	PROPN
admet-2874	174	22	.	.	PUNCT
admet-2874	175	1	[	[	X
admet-2874	175	2	85	85	NUM
admet-2874	175	3	]	]	PUNCT
admet-2874	175	4	,	,	PUNCT
admet-2874	175	5	uncovering	uncover	VERB
admet-2874	175	6	a	a	DET
admet-2874	175	7	new	new	ADJ
admet-2874	175	8	mechanism	mechanism	NOUN
admet-2874	175	9	by	by	ADP
admet-2874	175	10	which	which	PRON
admet-2874	175	11	a	a	DET
admet-2874	175	12	pparβ	pparβ	NOUN
admet-2874	175	13	/	/	SYM
admet-2874	175	14	δ	δ	NOUN
admet-2874	175	15	agonist	agonist	NOUN
admet-2874	175	16	(	(	PUNCT
admet-2874	175	17	gw501516	gw501516	PROPN
admet-2874	175	18	)	)	PUNCT
admet-2874	175	19	decreases	decrease	VERB
admet-2874	175	20	tgf	tgf	PROPN
admet-2874	175	21	-	-	PUNCT
admet-2874	175	22	β1	β1	NOUN
admet-2874	175	23	-	-	PUNCT
admet-2874	175	24	led	lead	VERB
admet-2874	175	25	activation	activation	NOUN
admet-2874	175	26	of	of	ADP
admet-2874	175	27	hscs	hsc	NOUN
admet-2874	175	28	and	and	CCONJ
admet-2874	175	29	fibrosis	fibrosis	NOUN
admet-2874	175	30	via	via	ADP
admet-2874	175	31	ampk	ampk	NOUN
admet-2874	175	32	signalling	signal	VERB
admet-2874	175	33	,	,	PUNCT
admet-2874	175	34	leading	lead	VERB
admet-2874	175	35	to	to	ADP
admet-2874	175	36	a	a	DET
admet-2874	175	37	reduction	reduction	NOUN
admet-2874	175	38	in	in	ADP
admet-2874	175	39	both	both	DET
admet-2874	175	40	smad3	smad3	NOUN
admet-2874	175	41	phosphorylation	phosphorylation	NOUN
admet-2874	175	42	and	and	CCONJ
admet-2874	175	43	p300	p300	NUM
admet-2874	175	44	levels	level	NOUN
admet-2874	175	45	.	.	PUNCT
admet-2874	176	1	table	table	NOUN
admet-2874	176	2	2	2	NUM
admet-2874	176	3	.	.	PUNCT
admet-2874	176	4	experimental	experimental	ADJ
admet-2874	176	5	approaches	approach	NOUN
admet-2874	176	6	of	of	ADP
admet-2874	176	7	the	the	DET
admet-2874	176	8	therapy	therapy	NOUN
admet-2874	176	9	of	of	ADP
admet-2874	176	10	liver	liver	NOUN
admet-2874	176	11	fibrosis	fibrosis	NOUN
admet-2874	176	12	target	target	NOUN
admet-2874	176	13	drug	drug	NOUN
admet-2874	176	14	/	/	SYM
admet-2874	176	15	components	component	NOUN
admet-2874	176	16	function	function	NOUN
admet-2874	176	17	/	/	SYM
admet-2874	176	18	pharmacological	pharmacological	NOUN
admet-2874	176	19	implication	implication	NOUN
admet-2874	176	20	ref	ref	NOUN
admet-2874	176	21	.	.	PUNCT
admet-2874	177	1	fxr	fxr	PROPN
admet-2874	177	2	id119031166	id119031166	PROPN
admet-2874	177	3	(	(	PUNCT
admet-2874	177	4	id166	id166	ADJ
admet-2874	177	5	)	)	PUNCT
admet-2874	177	6	regulate	regulate	VERB
admet-2874	177	7	bile	bile	NOUN
admet-2874	177	8	acid	acid	NOUN
admet-2874	177	9	homeostasis	homeostasis	NOUN
admet-2874	177	10	and	and	CCONJ
admet-2874	177	11	↓	↓	NOUN
admet-2874	177	12	liver	liver	NOUN
admet-2874	177	13	fibrosis	fibrosis	NOUN
admet-2874	177	14	and	and	CCONJ
admet-2874	177	15	nash	nash	PROPN
admet-2874	177	16	pathology	pathology	NOUN
admet-2874	177	17	without	without	ADP
admet-2874	177	18	activating	activate	VERB
admet-2874	177	19	itch	itch	NOUN
admet-2874	177	20	-	-	PUNCT
admet-2874	177	21	related	relate	VERB
admet-2874	177	22	receptors	receptor	NOUN
admet-2874	177	23	[	[	X
admet-2874	177	24	86	86	NUM
admet-2874	177	25	]	]	X
admet-2874	177	26	gw4064	gw4064	NOUN
admet-2874	177	27	inhibition	inhibition	NOUN
admet-2874	177	28	of	of	ADP
admet-2874	177	29	nf	nf	NOUN
admet-2874	177	30	-	-	PUNCT
admet-2874	177	31	kb	kb	NOUN
admet-2874	177	32	and	and	CCONJ
admet-2874	177	33	decrease	decrease	VERB
admet-2874	177	34	cytokine	cytokine	ADJ
admet-2874	177	35	-	-	PUNCT
admet-2874	177	36	stat3	stat3	NOUN
admet-2874	177	37	signalling	signal	VERB
admet-2874	177	38	[	[	X
admet-2874	177	39	87	87	NUM
admet-2874	177	40	]	]	PUNCT
admet-2874	177	41	int-787	int-787	NOUN
admet-2874	177	42	and	and	CCONJ
admet-2874	177	43	oca	oca	NOUN
admet-2874	177	44	modulate	modulate	VERB
admet-2874	177	45	reck	reck	NOUN
admet-2874	177	46	expression	expression	NOUN
admet-2874	177	47	,	,	PUNCT
admet-2874	177	48	↓	↓	PROPN
admet-2874	177	49	mmps	mmp	NOUN
admet-2874	177	50	,	,	PUNCT
admet-2874	177	51	adam10	adam10	NOUN
admet-2874	177	52	,	,	PUNCT
admet-2874	177	53	and	and	CCONJ
admet-2874	177	54	adam17	adam17	VERB
admet-2874	177	55	activity	activity	NOUN
admet-2874	177	56	[	[	X
admet-2874	177	57	88	88	NUM
admet-2874	177	58	]	]	PUNCT
admet-2874	177	59	int-767	int-767	NOUN
admet-2874	177	60	,	,	PUNCT
admet-2874	177	61	oca	oca	PROPN
admet-2874	177	62	↓	↓	PROPN
admet-2874	177	63	of	of	ADP
admet-2874	177	64	collagen	collagen	NOUN
admet-2874	177	65	and	and	CCONJ
admet-2874	177	66	induced	induce	VERB
admet-2874	177	67	mmp2	mmp2	ADJ
admet-2874	177	68	-	-	PUNCT
admet-2874	177	69	9	9	NUM
admet-2874	177	70	activity	activity	NOUN
admet-2874	177	71	[	[	X
admet-2874	177	72	89	89	NUM
admet-2874	177	73	]	]	X
admet-2874	177	74	gcdca	gcdca	NOUN
admet-2874	177	75	activating	activate	VERB
admet-2874	177	76	the	the	DET
admet-2874	177	77	nlrp3	nlrp3	NOUN
admet-2874	177	78	inflammasome	inflammasome	NOUN
admet-2874	177	79	pathway	pathway	NOUN
admet-2874	178	1	[	[	X
admet-2874	178	2	90	90	NUM
admet-2874	178	3	]	]	X
admet-2874	178	4	lxr	lxr	PROPN
admet-2874	178	5	and	and	CCONJ
admet-2874	178	6	fxr	fxr	NOUN
admet-2874	178	7	acanthoic	acanthoic	ADJ
admet-2874	178	8	acid	acid	NOUN
admet-2874	178	9	↓lipid	↓lipid	PROPN
admet-2874	178	10	accumulation	accumulation	NOUN
admet-2874	178	11	,	,	PUNCT
admet-2874	178	12	↓srebp1	↓srebp1	ADV
admet-2874	178	13	,	,	PUNCT
admet-2874	178	14	↑ampk	↑ampk	NOUN
admet-2874	178	15	-	-	PUNCT
admet-2874	178	16	sirt1	sirt1	NOUN
admet-2874	178	17	signaling	signal	VERB
admet-2874	178	18	[	[	X
admet-2874	178	19	76	76	NUM
admet-2874	178	20	]	]	X
admet-2874	178	21	lxr	lxr	PROPN
admet-2874	178	22	sesamol	sesamol	NOUN
admet-2874	178	23	inhibits	inhibit	VERB
admet-2874	178	24	autophagy	autophagy	ADJ
admet-2874	178	25	markers	marker	NOUN
admet-2874	178	26	maplc3α	maplc3α	PROPN
admet-2874	178	27	/	/	SYM
admet-2874	178	28	β	β	PROPN
admet-2874	178	29	,	,	PUNCT
admet-2874	178	30	p62	p62	NOUN
admet-2874	178	31	[	[	X
admet-2874	178	32	91	91	NUM
admet-2874	178	33	]	]	PUNCT
admet-2874	178	34	sr9238	sr9238	PROPN
admet-2874	178	35	sr9238	sr9238	PROPN
admet-2874	178	36	inhibits	inhibit	VERB
admet-2874	178	37	the	the	DET
admet-2874	178	38	activity	activity	NOUN
admet-2874	178	39	of	of	ADP
admet-2874	178	40	lxr	lxr	NOUN
admet-2874	179	1	[	[	X
admet-2874	179	2	92	92	NUM
admet-2874	179	3	]	]	PUNCT
admet-2874	179	4	pparγ	pparγ	ADJ
admet-2874	179	5	agonist	agonist	NOUN
admet-2874	179	6	gsk2033	gsk2033	NOUN
admet-2874	179	7	inhibit	inhibit	VERB
admet-2874	179	8	activity	activity	NOUN
admet-2874	179	9	of	of	ADP
admet-2874	179	10	lxr	lxr	PROPN
admet-2874	180	1	[	[	X
admet-2874	180	2	93	93	NUM
admet-2874	180	3	]	]	PUNCT
admet-2874	180	4	ppar	ppar	NOUN
admet-2874	180	5	agonist	agonist	NOUN
admet-2874	180	6	ligustrazine	ligustrazine	NOUN
admet-2874	180	7	inhibited	inhibit	VERB
admet-2874	180	8	hsc	hsc	NOUN
admet-2874	180	9	migration	migration	NOUN
admet-2874	180	10	,	,	PUNCT
admet-2874	180	11	adhesion	adhesion	NOUN
admet-2874	180	12	,	,	PUNCT
admet-2874	180	13	contraction	contraction	NOUN
admet-2874	180	14	,	,	PUNCT
admet-2874	180	15	and	and	CCONJ
admet-2874	180	16	angiogenic	angiogenic	ADJ
admet-2874	180	17	cytokine	cytokine	ADJ
admet-2874	180	18	production	production	NOUN
admet-2874	180	19	[	[	X
admet-2874	180	20	94	94	NUM
admet-2874	180	21	]	]	X
admet-2874	180	22	pparα	pparα	NOUN
admet-2874	180	23	methoxyeugenol	methoxyeugenol	NOUN
admet-2874	180	24	inhibiting	inhibit	VERB
admet-2874	180	25	hsc	hsc	NOUN
admet-2874	180	26	activation	activation	NOUN
admet-2874	180	27	[	[	X
admet-2874	180	28	95	95	NUM
admet-2874	180	29	]	]	PUNCT
admet-2874	180	30	oleoylethanolamide	oleoylethanolamide	ADJ
admet-2874	180	31	block	block	NOUN
admet-2874	180	32	activation	activation	NOUN
admet-2874	180	33	of	of	ADP
admet-2874	180	34	hsc	hsc	PROPN
admet-2874	180	35	inhibits	inhibit	VERB
admet-2874	180	36	alpha	alpha	ADJ
admet-2874	180	37	smooth	smooth	ADJ
admet-2874	180	38	muscle	muscle	NOUN
admet-2874	180	39	actin	actin	NOUN
admet-2874	180	40	,	,	PUNCT
admet-2874	180	41	tgf	tgf	PROPN
admet-2874	180	42	-	-	PUNCT
admet-2874	180	43	β1	β1	PROPN
admet-2874	180	44	[	[	X
admet-2874	180	45	96	96	NUM
admet-2874	180	46	]	]	X
admet-2874	180	47	pirfenidone	pirfenidone	NOUN
admet-2874	180	48	induced	induce	VERB
admet-2874	180	49	ppar	ppar	NOUN
admet-2874	180	50	-	-	PUNCT
admet-2874	180	51	α	α	NOUN
admet-2874	180	52	/	/	SYM
admet-2874	180	53	carnitine	carnitine	NOUN
admet-2874	180	54	o	o	NOUN
admet-2874	180	55	-	-	NOUN
admet-2874	180	56	palmitoyltransferase	palmitoyltransferase	ADJ
admet-2874	180	57	1	1	NUM
admet-2874	180	58	/	/	SYM
admet-2874	180	59	acylcoa	acylcoa	NOUN
admet-2874	180	60	oxidase	oxidase	NOUN
admet-2874	180	61	1	1	NUM
admet-2874	180	62	[	[	X
admet-2874	180	63	97	97	NUM
admet-2874	180	64	]	]	X
admet-2874	180	65	pparα	pparα	NOUN
admet-2874	180	66	/	/	SYM
admet-2874	180	67	δ	δ	PROPN
admet-2874	180	68	agonist	agonist	NOUN
admet-2874	180	69	zly16	zly16	NOUN
admet-2874	180	70	regulating	regulate	VERB
admet-2874	180	71	gene	gene	NOUN
admet-2874	180	72	expression	expression	NOUN
admet-2874	180	73	including	include	VERB
admet-2874	180	74	colia1	colia1	PROPN
admet-2874	180	75	,	,	PUNCT
admet-2874	180	76	timp	timp	PROPN
admet-2874	180	77	,	,	PUNCT
admet-2874	180	78	tgfβ	tgfβ	ADJ
admet-2874	180	79	,	,	PUNCT
admet-2874	180	80	tnfα	tnfα	NOUN
admet-2874	180	81	and	and	CCONJ
admet-2874	180	82	il6	il6	NOUN
admet-2874	180	83	[	[	X
admet-2874	180	84	98	98	NUM
admet-2874	180	85	]	]	X
admet-2874	180	86	pparα	pparα	NOUN
admet-2874	180	87	/	/	SYM
admet-2874	180	88	γ	γ	PROPN
admet-2874	180	89	agonist	agonist	NOUN
admet-2874	180	90	saroglitazar	saroglitazar	NOUN
admet-2874	180	91	decrease	decrease	NOUN
admet-2874	180	92	liver	liver	NOUN
admet-2874	180	93	collagen	collagen	NOUN
admet-2874	180	94	level	level	NOUN
admet-2874	180	95	and	and	CCONJ
admet-2874	180	96	cholangiocyte	cholangiocyte	NOUN
admet-2874	180	97	proliferation	proliferation	NOUN
admet-2874	180	98	marker	marker	NOUN
admet-2874	180	99	(	(	PUNCT
admet-2874	180	100	ck9	ck9	NOUN
admet-2874	180	101	)	)	PUNCT
admet-2874	181	1	[	[	X
admet-2874	181	2	99	99	NUM
admet-2874	181	3	]	]	SYM
admet-2874	181	4	integrin	integrin	NOUN
admet-2874	181	5	subunit	subunit	NOUN
admet-2874	181	6	alpha	alpha	NOUN
admet-2874	181	7	11	11	NUM
admet-2874	181	8	(	(	PUNCT
admet-2874	181	9	itga11	itga11	NOUN
admet-2874	181	10	)	)	PUNCT
admet-2874	181	11	micrornas	microrna	NOUN
admet-2874	181	12	(	(	PUNCT
admet-2874	181	13	eugol	eugol	NOUN
admet-2874	181	14	)	)	PUNCT
admet-2874	181	15	mir-12135	mir-12135	NOUN
admet-2874	181	16	suppressed	suppress	VERB
admet-2874	181	17	integrin	integrin	NOUN
admet-2874	181	18	subunit	subunit	NOUN
admet-2874	181	19	alpha	alpha	NOUN
admet-2874	181	20	11	11	NUM
admet-2874	181	21	(	(	PUNCT
admet-2874	181	22	itga11	itga11	NOUN
admet-2874	181	23	)	)	PUNCT
admet-2874	181	24	likewise	likewise	ADV
admet-2874	181	25	suppress	suppress	VERB
admet-2874	181	26	fibrosis	fibrosis	NOUN
admet-2874	181	27	[	[	X
admet-2874	181	28	100	100	NUM
admet-2874	181	29	]	]	PUNCT
admet-2874	181	30	pdgfrβ	pdgfrβ	NOUN
admet-2874	181	31	crenolanib	crenolanib	PROPN
admet-2874	181	32	crenolanib	crenolanib	NOUN
admet-2874	181	33	inhibit	inhibit	VERB
admet-2874	181	34	pdgfr	pdgfr	ADJ
admet-2874	181	35	-	-	PUNCT
admet-2874	181	36	β	β	X
admet-2874	181	37	inhibit	inhibit	VERB
admet-2874	181	38	hsc	hsc	NOUN
admet-2874	181	39	proliferation	proliferation	NOUN
admet-2874	181	40	[	[	X
admet-2874	181	41	101	101	NUM
admet-2874	181	42	]	]	PUNCT
admet-2874	181	43	salvianolic	salvianolic	ADJ
admet-2874	181	44	acid	acid	PROPN
admet-2874	181	45	b	b	PROPN
admet-2874	181	46	inhibit	inhibit	VERB
admet-2874	181	47	hsc	hsc	NOUN
admet-2874	181	48	activation	activation	NOUN
admet-2874	181	49	migration	migration	NOUN
admet-2874	181	50	and	and	CCONJ
admet-2874	181	51	proliferation	proliferation	NOUN
admet-2874	181	52	[	[	X
admet-2874	181	53	102	102	NUM
admet-2874	181	54	]	]	X
admet-2874	181	55	admet	admet	PROPN
admet-2874	181	56	&	&	CCONJ
admet-2874	181	57	dmpk	dmpk	PROPN
admet-2874	181	58	13(4	13(4	NUM
admet-2874	181	59	)	)	PUNCT
admet-2874	181	60	(	(	PUNCT
admet-2874	181	61	2025	2025	NUM
admet-2874	181	62	)	)	PUNCT
admet-2874	181	63	2874	2874	NUM
admet-2874	181	64	hscs	hsc	NOUN
admet-2874	181	65	in	in	ADP
admet-2874	181	66	liver	liver	NOUN
admet-2874	181	67	fibrosis	fibrosis	NOUN
admet-2874	181	68	:	:	PUNCT
admet-2874	181	69	therapeutic	therapeutic	ADJ
admet-2874	181	70	advances	advance	NOUN
admet-2874	181	71	doi	doi	NOUN
admet-2874	181	72	:	:	PUNCT
admet-2874	181	73	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	181	74	9	9	NUM
admet-2874	181	75	pdgf	pdgf	NOUN
admet-2874	181	76	benzimidazoisoquinoline	benzimidazoisoquinoline	NOUN
admet-2874	181	77	derivatives	derivative	NOUN
admet-2874	181	78	↓	↓	NOUN
admet-2874	181	79	pdgf	pdgf	PROPN
admet-2874	181	80	and	and	CCONJ
admet-2874	181	81	tgfβ	tgfβ	ADV
admet-2874	181	82	-	-	PUNCT
admet-2874	181	83	induced	induce	VERB
admet-2874	181	84	proliferation	proliferation	NOUN
admet-2874	181	85	[	[	X
admet-2874	181	86	103	103	NUM
admet-2874	181	87	]	]	X
admet-2874	181	88	pdgfrβ	pdgfrβ	NOUN
admet-2874	181	89	gomisin	gomisin	NOUN
admet-2874	181	90	d	d	AUX
admet-2874	181	91	inhibit	inhibit	VERB
admet-2874	181	92	hsc	hsc	PROPN
admet-2874	181	93	proliferation	proliferation	NOUN
admet-2874	181	94	,	,	PUNCT
admet-2874	181	95	activation	activation	NOUN
admet-2874	181	96	and	and	CCONJ
admet-2874	181	97	promote	promote	VERB
admet-2874	181	98	apoptosis	apoptosis	NOUN
admet-2874	181	99	[	[	X
admet-2874	181	100	104	104	NUM
admet-2874	181	101	]	]	X
admet-2874	181	102	igfiir	igfiir	ADJ
admet-2874	181	103	aptamer-20	aptamer-20	PROPN
admet-2874	181	104	(	(	PUNCT
admet-2874	181	105	selex	selex	NOUN
admet-2874	181	106	)	)	PUNCT
admet-2874	181	107	high	high	ADJ
admet-2874	181	108	-	-	PUNCT
admet-2874	181	109	affinity	affinity	NOUN
admet-2874	181	110	ligand	ligand	NOUN
admet-2874	181	111	to	to	PART
admet-2874	181	112	receptor	receptor	VERB
admet-2874	181	113	for	for	ADP
admet-2874	181	114	antifibrotic	antifibrotic	ADJ
admet-2874	181	115	activity	activity	NOUN
admet-2874	181	116	[	[	X
admet-2874	181	117	105	105	NUM
admet-2874	181	118	]	]	X
admet-2874	181	119	cannabinoid	cannabinoid	NOUN
admet-2874	181	120	receptor	receptor	NOUN
admet-2874	181	121	am1241	am1241	PROPN
admet-2874	181	122	inhibits	inhibit	VERB
admet-2874	181	123	the	the	DET
admet-2874	181	124	tlr4	tlr4	PROPN
admet-2874	181	125	/	/	SYM
admet-2874	181	126	nf	nf	NOUN
admet-2874	181	127	-	-	PUNCT
admet-2874	181	128	κb	κb	NOUN
admet-2874	181	129	pathway	pathway	NOUN
admet-2874	182	1	[	[	X
admet-2874	182	2	106	106	NUM
admet-2874	182	3	]	]	X
admet-2874	182	4	cannabigerol	cannabigerol	NOUN
admet-2874	182	5	↓	↓	PROPN
admet-2874	182	6	hepatic	hepatic	ADJ
admet-2874	182	7	inflammation	inflammation	NOUN
admet-2874	182	8	and	and	CCONJ
admet-2874	182	9	fibrosis	fibrosis	NOUN
admet-2874	182	10	[	[	X
admet-2874	182	11	107	107	NUM
admet-2874	182	12	]	]	PUNCT
admet-2874	182	13	exosomes	exosome	NOUN
admet-2874	182	14	upregulating	upregulating	ADJ
admet-2874	182	15	cb1	cb1	NOUN
admet-2874	182	16	receptors	receptor	NOUN
admet-2874	182	17	and	and	CCONJ
admet-2874	182	18	downregulating	downregulating	NOUN
admet-2874	182	19	cb2	cb2	PROPN
admet-2874	182	20	receptors	receptor	NOUN
admet-2874	182	21	[	[	X
admet-2874	182	22	108	108	NUM
admet-2874	182	23	]	]	PUNCT
admet-2874	182	24	cb1	cb1	NOUN
admet-2874	182	25	receptors	receptor	NOUN
admet-2874	182	26	jd5037	jd5037	VERB
admet-2874	182	27	activated	activate	VERB
admet-2874	182	28	hscs	hsc	NOUN
admet-2874	182	29	via	via	ADP
admet-2874	182	30	β	β	NOUN
admet-2874	182	31	-	-	ADJ
admet-2874	182	32	arrestin1	arrestin1	ADJ
admet-2874	182	33	/	/	SYM
admet-2874	182	34	akt	akt	PROPN
admet-2874	182	35	signalling	signalling	NOUN
admet-2874	182	36	,	,	PUNCT
admet-2874	182	37	which	which	PRON
admet-2874	182	38	is	be	AUX
admet-2874	182	39	inhibited	inhibit	VERB
admet-2874	182	40	by	by	ADP
admet-2874	182	41	jd5037	jd5037	PROPN
admet-2874	182	42	[	[	X
admet-2874	182	43	81	81	NUM
admet-2874	182	44	]	]	PUNCT
admet-2874	182	45	cb2	cb2	NOUN
admet-2874	182	46	receptors	receptor	NOUN
admet-2874	182	47	am1241	am1241	NOUN
admet-2874	182	48	inhibiting	inhibit	VERB
admet-2874	182	49	the	the	DET
admet-2874	182	50	tlr4	tlr4	NOUN
admet-2874	182	51	/	/	SYM
admet-2874	182	52	mir-155	mir-155	PROPN
admet-2874	182	53	/	/	SYM
admet-2874	182	54	nfκb	nfκb	NOUN
admet-2874	182	55	p65	p65	NOUN
admet-2874	182	56	pathway	pathway	NOUN
admet-2874	183	1	[	[	X
admet-2874	183	2	82	82	NUM
admet-2874	183	3	]	]	X
admet-2874	183	4	toll	toll	NOUN
admet-2874	183	5	like	like	ADP
admet-2874	183	6	receptor	receptor	NOUN
admet-2874	183	7	alt-100	alt-100	VERB
admet-2874	183	8	neutralizing	neutralize	VERB
admet-2874	183	9	enampt	enampt	NOUN
admet-2874	183	10	,	,	PUNCT
admet-2874	183	11	thereby	thereby	ADV
admet-2874	183	12	inhibiting	inhibit	VERB
admet-2874	183	13	the	the	DET
admet-2874	183	14	enampt	enampt	ADJ
admet-2874	183	15	/	/	SYM
admet-2874	183	16	tlr4	tlr4	NOUN
admet-2874	183	17	inflammatory	inflammatory	ADJ
admet-2874	183	18	pathway	pathway	NOUN
admet-2874	184	1	[	[	X
admet-2874	184	2	84	84	NUM
admet-2874	184	3	]	]	PUNCT
admet-2874	184	4	rutin	rutin	NOUN
admet-2874	184	5	inhibiting	inhibit	VERB
admet-2874	184	6	the	the	DET
admet-2874	184	7	tlr4	tlr4	NOUN
admet-2874	184	8	(	(	PUNCT
admet-2874	184	9	toll	toll	NOUN
admet-2874	184	10	-	-	PUNCT
admet-2874	184	11	like	like	ADJ
admet-2874	184	12	receptor	receptor	NOUN
admet-2874	184	13	4	4	NUM
admet-2874	184	14	)	)	PUNCT
admet-2874	184	15	and	and	CCONJ
admet-2874	184	16	p2x7r	p2x7r	VERB
admet-2874	184	17	signalling	signal	VERB
admet-2874	184	18	pathways	pathway	NOUN
admet-2874	185	1	[	[	X
admet-2874	185	2	109	109	NUM
admet-2874	185	3	]	]	PUNCT
admet-2874	185	4	protein	protein	NOUN
admet-2874	185	5	tyrosine	tyrosine	NOUN
admet-2874	185	6	phosphatase	phosphatase	NOUN
admet-2874	185	7	1b	1b	NUM
admet-2874	185	8	luteolin-7	luteolin-7	PROPN
admet-2874	185	9	-	-	PUNCT
admet-2874	185	10	diglucuronide	diglucuronide	NOUN
admet-2874	185	11	↓	↓	PROPN
admet-2874	185	12	tgf	tgf	PROPN
admet-2874	185	13	-	-	PUNCT
admet-2874	185	14	β1	β1	NOUN
admet-2874	185	15	-	-	PUNCT
admet-2874	185	16	mediated	mediate	VERB
admet-2874	185	17	overexpression	overexpression	NOUN
admet-2874	185	18	of	of	ADP
admet-2874	185	19	collagen	collagen	NOUN
admet-2874	185	20	1	1	NUM
admet-2874	185	21	,	,	PUNCT
admet-2874	185	22	α	α	NOUN
admet-2874	185	23	-	-	PUNCT
admet-2874	185	24	sma	sma	NOUN
admet-2874	185	25	and	and	CCONJ
admet-2874	185	26	fibronectin	fibronectin	NOUN
admet-2874	185	27	[	[	X
admet-2874	185	28	110	110	NUM
admet-2874	185	29	]	]	X
admet-2874	185	30	nf	nf	NOUN
admet-2874	185	31	-	-	PUNCT
admet-2874	185	32	κb	κb	NOUN
admet-2874	185	33	/	/	SYM
admet-2874	185	34	nlrp3	nlrp3	NOUN
admet-2874	185	35	inflammasome	inflammasome	NOUN
admet-2874	185	36	signaling	signal	VERB
admet-2874	185	37	axis	axis	NOUN
admet-2874	185	38	mangiferin	mangiferin	NOUN
admet-2874	185	39	↓nf	↓nf	NOUN
admet-2874	185	40	-	-	PUNCT
admet-2874	185	41	κb	κb	ADJ
admet-2874	185	42	/	/	SYM
admet-2874	185	43	nlrp3	nlrp3	NOUN
admet-2874	185	44	inflammasome	inflammasome	NOUN
admet-2874	185	45	pathway	pathway	NOUN
admet-2874	185	46	,	,	PUNCT
admet-2874	185	47	↓	↓	PROPN
admet-2874	185	48	α	α	X
admet-2874	185	49	-	-	PUNCT
admet-2874	185	50	sma	sma	NOUN
admet-2874	185	51	hepatic	hepatic	ADJ
admet-2874	185	52	expression	expression	NOUN
admet-2874	185	53	and	and	CCONJ
admet-2874	185	54	fibrous	fibrous	ADJ
admet-2874	185	55	tissue	tissue	NOUN
admet-2874	185	56	deposit	deposit	NOUN
admet-2874	185	57	.	.	PUNCT
admet-2874	186	1	↓	↓	PROPN
admet-2874	186	2	mda	mda	PROPN
admet-2874	186	3	and	and	CCONJ
admet-2874	186	4	↑	↑	PROPN
admet-2874	186	5	gsh	gsh	PROPN
admet-2874	186	6	and	and	CCONJ
admet-2874	186	7	nrf2	nrf2	PROPN
admet-2874	187	1	[	[	X
admet-2874	187	2	111	111	NUM
admet-2874	187	3	]	]	PUNCT
admet-2874	187	4	apolipoprotein	apolipoprotein	ADJ
admet-2874	187	5	l2	l2	VERB
admet-2874	187	6	12	12	NUM
admet-2874	187	7	-	-	PUNCT
admet-2874	187	8	deoxyphorbol	deoxyphorbol	NOUN
admet-2874	187	9	13	13	NUM
admet-2874	187	10	-	-	PUNCT
admet-2874	187	11	palmitate	palmitate	NOUN
admet-2874	187	12	↓apol2	↓apol2	NOUN
admet-2874	187	13	-	-	PUNCT
admet-2874	187	14	serca2	serca2	NOUN
admet-2874	187	15	-	-	PUNCT
admet-2874	187	16	perk	perk	NOUN
admet-2874	187	17	-	-	PUNCT
admet-2874	187	18	hes1	hes1	NOUN
admet-2874	187	19	signalling	signal	VERB
admet-2874	187	20	[	[	X
admet-2874	187	21	112	112	NUM
admet-2874	187	22	]	]	PUNCT
admet-2874	187	23	gsk-3β	gsk-3β	ADJ
admet-2874	187	24	modulation	modulation	NOUN
admet-2874	187	25	fluorofenidone	fluorofenidone	NOUN
admet-2874	187	26	targets	target	NOUN
admet-2874	187	27	gsk-3β	gsk-3β	PROPN
admet-2874	187	28	/	/	SYM
admet-2874	187	29	β	β	NOUN
admet-2874	187	30	-	-	ADJ
admet-2874	187	31	catenin	catenin	ADJ
admet-2874	187	32	pathway	pathway	NOUN
admet-2874	187	33	,	,	PUNCT
admet-2874	187	34	↓	↓	NOUN
admet-2874	187	35	β	β	X
admet-2874	187	36	-	-	ADJ
admet-2874	187	37	catenin	catenin	NOUN
admet-2874	187	38	-	-	PUNCT
admet-2874	187	39	mediated	mediate	VERB
admet-2874	187	40	pro	pro	ADJ
admet-2874	187	41	-	-	ADJ
admet-2874	187	42	fibrotic	fibrotic	ADJ
admet-2874	187	43	gene	gene	NOUN
admet-2874	187	44	expression	expression	NOUN
admet-2874	187	45	,	,	PUNCT
admet-2874	187	46	↑	↑	PROPN
admet-2874	187	47	nrf2	nrf2	PROPN
admet-2874	187	48	/	/	SYM
admet-2874	187	49	ho-1	ho-1	NOUN
admet-2874	187	50	pathway	pathway	NOUN
admet-2874	187	51	↓	↓	PROPN
admet-2874	187	52	oxidative	oxidative	ADJ
admet-2874	187	53	stress	stress	NOUN
admet-2874	187	54	,	,	PUNCT
admet-2874	187	55	↓	↓	PROPN
admet-2874	187	56	hepatocyte	hepatocyte	NOUN
admet-2874	187	57	apoptosis	apoptosis	NOUN
admet-2874	187	58	[	[	X
admet-2874	187	59	113	113	NUM
admet-2874	187	60	]	]	X
admet-2874	187	61	ampk	ampk	NOUN
admet-2874	187	62	-	-	PUNCT
admet-2874	187	63	pparγ	pparγ	NOUN
admet-2874	187	64	pathway	pathway	NOUN
admet-2874	187	65	arctigenin	arctigenin	VERB
admet-2874	187	66	↓	↓	NOUN
admet-2874	187	67	expression	expression	NOUN
admet-2874	187	68	of	of	ADP
admet-2874	187	69	fibrosis	fibrosis	NOUN
admet-2874	187	70	-	-	PUNCT
admet-2874	187	71	related	relate	VERB
admet-2874	187	72	genes	gene	NOUN
admet-2874	187	73	(	(	PUNCT
admet-2874	187	74	col1a1	col1a1	NOUN
admet-2874	187	75	,	,	PUNCT
admet-2874	187	76	col3a1	col3a1	PROPN
admet-2874	187	77	,	,	PUNCT
admet-2874	187	78	acta2	acta2	PROPN
admet-2874	187	79	)	)	PUNCT
admet-2874	187	80	,	,	PUNCT
admet-2874	187	81	reversal	reversal	NOUN
admet-2874	187	82	of	of	ADP
admet-2874	187	83	activated	activate	VERB
admet-2874	187	84	hscs	hsc	NOUN
admet-2874	187	85	to	to	PART
admet-2874	187	86	quiescent	quiescent	ADJ
admet-2874	187	87	hscs	hsc	NOUN
admet-2874	187	88	[	[	X
admet-2874	187	89	114	114	NUM
admet-2874	187	90	]	]	PUNCT
admet-2874	187	91	drug	drug	NOUN
admet-2874	187	92	delivery	delivery	NOUN
admet-2874	187	93	in	in	ADP
admet-2874	187	94	liver	liver	NOUN
admet-2874	187	95	fibrosis	fibrosis	NOUN
admet-2874	187	96	the	the	DET
admet-2874	187	97	liver	liver	NOUN
admet-2874	187	98	,	,	PUNCT
admet-2874	187	99	as	as	ADP
admet-2874	187	100	an	an	DET
admet-2874	187	101	organ	organ	NOUN
admet-2874	187	102	,	,	PUNCT
admet-2874	187	103	is	be	AUX
admet-2874	187	104	actively	actively	ADV
admet-2874	187	105	involved	involve	VERB
admet-2874	187	106	in	in	ADP
admet-2874	187	107	the	the	DET
admet-2874	187	108	metabolism	metabolism	NOUN
admet-2874	187	109	of	of	ADP
admet-2874	187	110	drugs	drug	NOUN
admet-2874	187	111	,	,	PUNCT
admet-2874	187	112	and	and	CCONJ
admet-2874	187	113	most	most	ADJ
admet-2874	187	114	drugs	drug	NOUN
admet-2874	187	115	encounter	encounter	VERB
admet-2874	187	116	liver	liver	NOUN
admet-2874	187	117	tissue	tissue	NOUN
admet-2874	187	118	at	at	ADP
admet-2874	187	119	higher	high	ADJ
admet-2874	187	120	concentrations	concentration	NOUN
admet-2874	187	121	due	due	ADP
admet-2874	187	122	to	to	ADP
admet-2874	187	123	the	the	DET
admet-2874	187	124	presence	presence	NOUN
admet-2874	187	125	of	of	ADP
admet-2874	187	126	receptors	receptor	NOUN
admet-2874	187	127	and	and	CCONJ
admet-2874	187	128	transporters	transporter	NOUN
admet-2874	187	129	in	in	ADP
admet-2874	187	130	hepatocytes	hepatocyte	NOUN
admet-2874	187	131	.	.	PUNCT
admet-2874	188	1	apart	apart	ADV
admet-2874	188	2	from	from	ADP
admet-2874	188	3	the	the	DET
admet-2874	188	4	presence	presence	NOUN
admet-2874	188	5	of	of	ADP
admet-2874	188	6	a	a	DET
admet-2874	188	7	major	major	ADJ
admet-2874	188	8	macrophage	macrophage	ADJ
admet-2874	188	9	population	population	NOUN
admet-2874	188	10	,	,	PUNCT
admet-2874	188	11	it	it	PRON
admet-2874	188	12	also	also	ADV
admet-2874	188	13	facilitates	facilitate	VERB
admet-2874	188	14	the	the	DET
admet-2874	188	15	accumulation	accumulation	NOUN
admet-2874	188	16	of	of	ADP
admet-2874	188	17	high	high	ADJ
admet-2874	188	18	-	-	PUNCT
admet-2874	188	19	molecular	molecular	ADJ
admet-2874	188	20	-	-	PUNCT
admet-2874	188	21	weight	weight	NOUN
admet-2874	188	22	drugs	drug	NOUN
admet-2874	188	23	,	,	PUNCT
admet-2874	188	24	especially	especially	ADV
admet-2874	188	25	peptides	peptide	NOUN
admet-2874	188	26	and	and	CCONJ
admet-2874	188	27	proteins	protein	NOUN
admet-2874	188	28	.	.	PUNCT
admet-2874	189	1	however	however	ADV
admet-2874	189	2	,	,	PUNCT
admet-2874	189	3	in	in	ADP
admet-2874	189	4	the	the	DET
admet-2874	189	5	case	case	NOUN
admet-2874	189	6	of	of	ADP
admet-2874	189	7	liver	liver	NOUN
admet-2874	189	8	fibrosis	fibrosis	NOUN
admet-2874	189	9	,	,	PUNCT
admet-2874	189	10	the	the	DET
admet-2874	189	11	involvement	involvement	NOUN
admet-2874	189	12	of	of	ADP
admet-2874	189	13	other	other	ADJ
admet-2874	189	14	cell	cell	NOUN
admet-2874	189	15	types	type	NOUN
admet-2874	189	16	present	present	ADJ
admet-2874	189	17	in	in	ADP
admet-2874	189	18	the	the	DET
admet-2874	189	19	liver	liver	NOUN
admet-2874	189	20	has	have	AUX
admet-2874	189	21	been	be	AUX
admet-2874	189	22	demonstrated	demonstrate	VERB
admet-2874	189	23	;	;	PUNCT
admet-2874	189	24	hence	hence	ADV
admet-2874	189	25	,	,	PUNCT
admet-2874	189	26	targeting	target	VERB
admet-2874	189	27	cells	cell	NOUN
admet-2874	189	28	apart	apart	ADV
admet-2874	189	29	from	from	ADP
admet-2874	189	30	hepatocytes	hepatocyte	NOUN
admet-2874	189	31	and	and	CCONJ
admet-2874	189	32	macrophages	macrophage	NOUN
admet-2874	189	33	has	have	AUX
admet-2874	189	34	become	become	VERB
admet-2874	189	35	an	an	DET
admet-2874	189	36	important	important	ADJ
admet-2874	189	37	approach	approach	NOUN
admet-2874	189	38	that	that	PRON
admet-2874	189	39	has	have	AUX
admet-2874	189	40	been	be	AUX
admet-2874	189	41	explored	explore	VERB
admet-2874	189	42	recently	recently	ADV
admet-2874	189	43	for	for	ADP
admet-2874	189	44	therapeutic	therapeutic	ADJ
admet-2874	189	45	intervention	intervention	NOUN
admet-2874	189	46	in	in	ADP
admet-2874	189	47	liver	liver	NOUN
admet-2874	189	48	fibrosis	fibrosis	NOUN
admet-2874	189	49	.	.	PUNCT
admet-2874	190	1	active	active	ADJ
admet-2874	190	2	targeting	target	VERB
admet-2874	190	3	targeted	target	VERB
admet-2874	190	4	delivery	delivery	NOUN
admet-2874	190	5	of	of	ADP
admet-2874	190	6	drugs	drug	NOUN
admet-2874	190	7	to	to	ADP
admet-2874	190	8	specific	specific	ADJ
admet-2874	190	9	cell	cell	NOUN
admet-2874	190	10	subpopulations	subpopulation	NOUN
admet-2874	190	11	in	in	ADP
admet-2874	190	12	the	the	DET
admet-2874	190	13	liver	liver	NOUN
admet-2874	190	14	can	can	AUX
admet-2874	190	15	be	be	AUX
admet-2874	190	16	a	a	DET
admet-2874	190	17	crucial	crucial	ADJ
admet-2874	190	18	strategy	strategy	NOUN
admet-2874	190	19	,	,	PUNCT
admet-2874	190	20	particularly	particularly	ADV
admet-2874	190	21	with	with	ADP
admet-2874	190	22	a	a	DET
admet-2874	190	23	deeper	deep	ADJ
admet-2874	190	24	understanding	understanding	NOUN
admet-2874	190	25	of	of	ADP
admet-2874	190	26	the	the	DET
admet-2874	190	27	function	function	NOUN
admet-2874	190	28	of	of	ADP
admet-2874	190	29	specific	specific	ADJ
admet-2874	190	30	cell	cell	NOUN
admet-2874	190	31	subtypes	subtype	NOUN
admet-2874	190	32	in	in	ADP
admet-2874	190	33	liver	liver	NOUN
admet-2874	190	34	fibrosis	fibrosis	NOUN
admet-2874	190	35	.	.	PUNCT
admet-2874	191	1	even	even	ADV
admet-2874	191	2	in	in	ADP
admet-2874	191	3	the	the	DET
admet-2874	191	4	same	same	ADJ
admet-2874	191	5	organ	organ	NOUN
admet-2874	191	6	,	,	PUNCT
admet-2874	191	7	this	this	DET
admet-2874	191	8	method	method	NOUN
admet-2874	191	9	reduces	reduce	VERB
admet-2874	191	10	undesirable	undesirable	ADJ
admet-2874	191	11	side	side	NOUN
admet-2874	191	12	effects	effect	NOUN
admet-2874	191	13	and	and	CCONJ
admet-2874	191	14	improves	improve	VERB
admet-2874	191	15	the	the	DET
admet-2874	191	16	therapeutic	therapeutic	ADJ
admet-2874	191	17	outcome	outcome	NOUN
admet-2874	191	18	of	of	ADP
admet-2874	191	19	the	the	DET
admet-2874	191	20	treatment	treatment	NOUN
admet-2874	191	21	.	.	PUNCT
admet-2874	192	1	cellspecific	cellspecific	NOUN
admet-2874	192	2	targeting	target	VERB
admet-2874	192	3	employs	employ	VERB
admet-2874	192	4	specific	specific	ADJ
admet-2874	192	5	ligands	ligand	NOUN
admet-2874	192	6	targeting	target	VERB
admet-2874	192	7	receptors	receptor	NOUN
admet-2874	192	8	selectively	selectively	ADV
admet-2874	192	9	expressed	express	VERB
admet-2874	192	10	in	in	ADP
admet-2874	192	11	the	the	DET
admet-2874	192	12	desired	desire	VERB
admet-2874	192	13	cell	cell	NOUN
admet-2874	192	14	type	type	NOUN
admet-2874	192	15	,	,	PUNCT
admet-2874	192	16	in	in	ADP
admet-2874	192	17	the	the	DET
admet-2874	192	18	case	case	NOUN
admet-2874	192	19	of	of	ADP
admet-2874	192	20	a	a	DET
admet-2874	192	21	disease	disease	NOUN
admet-2874	192	22	,	,	PUNCT
admet-2874	192	23	in	in	ADP
admet-2874	192	24	addition	addition	NOUN
admet-2874	192	25	to	to	ADP
admet-2874	192	26	the	the	DET
admet-2874	192	27	physicochemical	physicochemical	ADJ
admet-2874	192	28	properties	property	NOUN
admet-2874	192	29	of	of	ADP
admet-2874	192	30	nanocarriers	nanocarrier	NOUN
admet-2874	192	31	.	.	PUNCT
admet-2874	193	1	these	these	DET
admet-2874	193	2	ligands	ligand	NOUN
admet-2874	193	3	are	be	AUX
admet-2874	193	4	attached	attach	VERB
admet-2874	193	5	chemically	chemically	ADV
admet-2874	193	6	to	to	ADP
admet-2874	193	7	the	the	DET
admet-2874	193	8	nanocarrier	nanocarrier	PROPN
admet-2874	193	9	surface	surface	NOUN
admet-2874	193	10	,	,	PUNCT
admet-2874	193	11	enabling	enable	VERB
admet-2874	193	12	active	active	ADJ
admet-2874	193	13	targeting	targeting	NOUN
admet-2874	193	14	and	and	CCONJ
admet-2874	193	15	increasing	increase	VERB
admet-2874	193	16	the	the	DET
admet-2874	193	17	specificity	specificity	NOUN
admet-2874	193	18	of	of	ADP
admet-2874	193	19	the	the	DET
admet-2874	193	20	therapy	therapy	NOUN
admet-2874	193	21	.	.	PUNCT
admet-2874	194	1	a	a	DET
admet-2874	194	2	summary	summary	NOUN
admet-2874	194	3	overview	overview	NOUN
admet-2874	194	4	of	of	ADP
admet-2874	194	5	active	active	ADJ
admet-2874	194	6	targeting	target	VERB
admet-2874	194	7	drug	drug	NOUN
admet-2874	194	8	delivery	delivery	NOUN
admet-2874	194	9	systems	system	NOUN
admet-2874	194	10	and	and	CCONJ
admet-2874	194	11	their	their	PRON
admet-2874	194	12	associated	associate	VERB
admet-2874	194	13	ligands	ligand	NOUN
admet-2874	194	14	in	in	ADP
admet-2874	194	15	liver	liver	NOUN
admet-2874	194	16	fibrosis	fibrosis	NOUN
admet-2874	194	17	is	be	AUX
admet-2874	194	18	presented	present	VERB
admet-2874	194	19	in	in	ADP
admet-2874	194	20	figure	figure	NOUN
admet-2874	194	21	4	4	NUM
admet-2874	194	22	.	.	PUNCT
admet-2874	195	1	recent	recent	ADJ
admet-2874	195	2	studies	study	NOUN
admet-2874	195	3	demonstrated	demonstrate	VERB
admet-2874	195	4	utilization	utilization	NOUN
admet-2874	195	5	of	of	ADP
admet-2874	195	6	innovative	innovative	ADJ
admet-2874	195	7	nanocarriers	nanocarrier	NOUN
admet-2874	195	8	for	for	ADP
admet-2874	195	9	targeting	target	VERB
admet-2874	195	10	hepatic	hepatic	ADJ
admet-2874	195	11	stellate	stellate	ADJ
admet-2874	195	12	cells	cell	NOUN
admet-2874	195	13	(	(	PUNCT
admet-2874	195	14	hscs	hsc	NOUN
admet-2874	195	15	)	)	PUNCT
admet-2874	195	16	in	in	ADP
admet-2874	195	17	liver	liver	NOUN
admet-2874	195	18	fibrosis	fibrosis	NOUN
admet-2874	195	19	.	.	PUNCT
admet-2874	196	1	many	many	ADJ
admet-2874	196	2	carriers	carrier	NOUN
admet-2874	196	3	,	,	PUNCT
admet-2874	196	4	such	such	ADJ
admet-2874	196	5	as	as	ADP
admet-2874	196	6	silica	silica	NOUN
admet-2874	196	7	cross	cross	ADJ
admet-2874	196	8	-	-	ADJ
admet-2874	196	9	linked	link	VERB
admet-2874	196	10	micelles	micelle	NOUN
admet-2874	196	11	coloaded	coloade	VERB
admet-2874	196	12	with	with	ADP
admet-2874	196	13	silibinin	silibinin	NOUN
admet-2874	196	14	and	and	CCONJ
admet-2874	196	15	sorafenib	sorafenib	NOUN
admet-2874	196	16	modified	modify	VERB
admet-2874	196	17	with	with	ADP
admet-2874	196	18	the	the	DET
admet-2874	196	19	ctce9908	ctce9908	PROPN
admet-2874	196	20	peptide	peptide	NOUN
admet-2874	196	21	,	,	PUNCT
admet-2874	196	22	cd44	cd44	PROPN
admet-2874	196	23	receptor	receptor	NOUN
admet-2874	196	24	-	-	PUNCT
admet-2874	196	25	targeted	target	VERB
admet-2874	196	26	nanoparticles	nanoparticle	NOUN
admet-2874	196	27	co	co	VERB
admet-2874	196	28	-	-	VERB
admet-2874	196	29	loaded	load	VERB
admet-2874	196	30	with	with	ADP
admet-2874	196	31	probucol	probucol	PROPN
admet-2874	196	32	and	and	CCONJ
admet-2874	196	33	collagenase	collagenase	NOUN
admet-2874	196	34	i	i	PROPN
admet-2874	196	35	,	,	PUNCT
admet-2874	196	36	palmitic	palmitic	ADJ
admet-2874	196	37	acid	acid	NOUN
admet-2874	196	38	-	-	PUNCT
admet-2874	196	39	modified	modify	VERB
admet-2874	196	40	albumin	albumin	ADJ
admet-2874	196	41	nanoparticles	nanoparticle	NOUN
admet-2874	196	42	,	,	PUNCT
admet-2874	196	43	and	and	CCONJ
admet-2874	196	44	endothelin	endothelin	PROPN
admet-2874	196	45	receptor	receptor	NOUN
admet-2874	196	46	antagonist	antagonist	NOUN
admet-2874	196	47	(	(	PUNCT
admet-2874	196	48	ch948	ch948	PROPN
admet-2874	196	49	,	,	PUNCT
admet-2874	196	50	a	a	DET
admet-2874	196	51	derivative	derivative	NOUN
admet-2874	196	52	of	of	ADP
admet-2874	196	53	pd-156707	pd-156707	NOUN
admet-2874	196	54	)	)	PUNCT
admet-2874	196	55	conjugated	conjugate	VERB
admet-2874	196	56	spions	spion	NOUN
admet-2874	196	57	mri	mri	PROPN
admet-2874	196	58	,	,	PUNCT
admet-2874	196	59	have	have	AUX
admet-2874	196	60	also	also	ADV
admet-2874	196	61	been	be	AUX
admet-2874	196	62	explored	explore	VERB
admet-2874	196	63	(	(	PUNCT
admet-2874	196	64	table	table	NOUN
admet-2874	196	65	3	3	NUM
admet-2874	196	66	)	)	PUNCT
admet-2874	196	67	.	.	PUNCT
admet-2874	197	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	197	2	a.	a.	NOUN
admet-2874	197	3	singh	singh	PROPN
admet-2874	197	4	et	et	PROPN
admet-2874	197	5	al	al	PROPN
admet-2874	197	6	.	.	PROPN
admet-2874	197	7	admet	admet	PROPN
admet-2874	197	8	&	&	CCONJ
admet-2874	197	9	dmpk	dmpk	PROPN
admet-2874	197	10	13(4	13(4	NUM
admet-2874	197	11	)	)	PUNCT
admet-2874	197	12	(	(	PUNCT
admet-2874	197	13	2025	2025	NUM
admet-2874	197	14	)	)	PUNCT
admet-2874	197	15	2874	2874	NUM
admet-2874	197	16	10	10	NUM
admet-2874	197	17	figure	figure	NOUN
admet-2874	197	18	4	4	NUM
admet-2874	197	19	.	.	PUNCT
admet-2874	197	20	major	major	ADJ
admet-2874	197	21	drug	drug	NOUN
admet-2874	197	22	delivery	delivery	NOUN
admet-2874	197	23	systems	system	NOUN
admet-2874	197	24	with	with	ADP
admet-2874	197	25	active	active	ADJ
admet-2874	197	26	targeting	target	VERB
admet-2874	197	27	agents	agent	NOUN
admet-2874	197	28	use	use	VERB
admet-2874	197	29	for	for	ADP
admet-2874	197	30	the	the	DET
admet-2874	197	31	therapy	therapy	NOUN
admet-2874	197	32	of	of	ADP
admet-2874	197	33	liver	liver	NOUN
admet-2874	197	34	fibrosis	fibrosis	NOUN
admet-2874	197	35	(	(	PUNCT
admet-2874	197	36	created	create	VERB
admet-2874	197	37	in	in	ADP
admet-2874	197	38	biorender	biorender	NOUN
admet-2874	197	39	.	.	PUNCT
admet-2874	198	1	awasthi	awasthi	PROPN
admet-2874	198	2	,	,	PUNCT
admet-2874	198	3	r.	r.	PROPN
admet-2874	198	4	(	(	PUNCT
admet-2874	198	5	2025	2025	NUM
admet-2874	198	6	)	)	PUNCT
admet-2874	198	7	https://biorender.com/obrtwsc	https://biorender.com/obrtwsc	X
admet-2874	198	8	)	)	PUNCT
admet-2874	199	1	advances	advance	NOUN
admet-2874	199	2	in	in	ADP
admet-2874	199	3	active	active	ADJ
admet-2874	199	4	targeting	target	VERB
admet-2874	199	5	inherent	inherent	ADJ
admet-2874	199	6	redundancy	redundancy	NOUN
admet-2874	199	7	in	in	ADP
admet-2874	199	8	fibrogenic	fibrogenic	ADJ
admet-2874	199	9	signalling	signal	VERB
admet-2874	199	10	pathways	pathway	NOUN
admet-2874	199	11	means	mean	VERB
admet-2874	199	12	that	that	SCONJ
admet-2874	199	13	targeting	target	VERB
admet-2874	199	14	a	a	DET
admet-2874	199	15	single	single	ADJ
admet-2874	199	16	molecular	molecular	ADJ
admet-2874	199	17	pathway	pathway	NOUN
admet-2874	199	18	often	often	ADV
admet-2874	199	19	fails	fail	VERB
admet-2874	199	20	to	to	PART
admet-2874	199	21	halt	halt	VERB
admet-2874	199	22	disease	disease	NOUN
admet-2874	199	23	progression	progression	NOUN
admet-2874	199	24	.	.	PUNCT
admet-2874	200	1	this	this	DET
admet-2874	200	2	fact	fact	NOUN
admet-2874	200	3	has	have	AUX
admet-2874	200	4	recently	recently	ADV
admet-2874	200	5	led	lead	VERB
admet-2874	200	6	to	to	ADP
admet-2874	200	7	the	the	DET
admet-2874	200	8	development	development	NOUN
admet-2874	200	9	of	of	ADP
admet-2874	200	10	various	various	ADJ
admet-2874	200	11	experimental	experimental	ADJ
admet-2874	200	12	therapeutic	therapeutic	ADJ
admet-2874	200	13	approaches	approach	NOUN
admet-2874	200	14	targeting	target	VERB
admet-2874	200	15	multiple	multiple	ADJ
admet-2874	200	16	targets	target	NOUN
admet-2874	200	17	using	use	VERB
admet-2874	200	18	a	a	DET
admet-2874	200	19	combination	combination	NOUN
admet-2874	200	20	of	of	ADP
admet-2874	200	21	two	two	NUM
admet-2874	200	22	or	or	CCONJ
admet-2874	200	23	more	more	ADJ
admet-2874	200	24	drugs	drug	NOUN
admet-2874	200	25	and	and	CCONJ
admet-2874	200	26	targeting	target	VERB
admet-2874	200	27	approaches	approach	NOUN
admet-2874	200	28	(	(	PUNCT
admet-2874	200	29	see	see	VERB
admet-2874	200	30	table	table	NOUN
admet-2874	200	31	3	3	NUM
admet-2874	200	32	)	)	PUNCT
admet-2874	200	33	.	.	PUNCT
admet-2874	201	1	recently	recently	ADV
admet-2874	201	2	,	,	PUNCT
admet-2874	201	3	a	a	DET
admet-2874	201	4	reported	report	VERB
admet-2874	201	5	study	study	NOUN
admet-2874	201	6	demonstrated	demonstrate	VERB
admet-2874	201	7	a	a	DET
admet-2874	201	8	novel	novel	NOUN
admet-2874	201	9	targeted	target	VERB
admet-2874	201	10	therapeutic	therapeutic	ADJ
admet-2874	201	11	strategy	strategy	NOUN
admet-2874	201	12	for	for	ADP
admet-2874	201	13	liver	liver	NOUN
admet-2874	201	14	fibrosis	fibrosis	NOUN
admet-2874	201	15	using	use	VERB
admet-2874	201	16	mesenchymal	mesenchymal	ADJ
admet-2874	201	17	stromal	stromal	ADJ
admet-2874	201	18	cells	cell	NOUN
admet-2874	201	19	(	(	PUNCT
admet-2874	201	20	mscs	msc	NOUN
admet-2874	201	21	)	)	PUNCT
admet-2874	201	22	engineered	engineer	VERB
admet-2874	201	23	with	with	ADP
admet-2874	201	24	a	a	DET
admet-2874	201	25	high	high	ADJ
admet-2874	201	26	-	-	PUNCT
admet-2874	201	27	affinity	affinity	NOUN
admet-2874	201	28	peptide	peptide	NOUN
admet-2874	201	29	ligand	ligand	NOUN
admet-2874	201	30	(	(	PUNCT
admet-2874	201	31	ppb	ppb	NOUN
admet-2874	201	32	)	)	PUNCT
admet-2874	201	33	specific	specific	NOUN
admet-2874	201	34	for	for	ADP
admet-2874	201	35	the	the	DET
admet-2874	201	36	platelet	platelet	NOUN
admet-2874	201	37	-	-	PUNCT
admet-2874	201	38	derived	derive	VERB
admet-2874	201	39	growth	growth	NOUN
admet-2874	201	40	factor	factor	NOUN
admet-2874	201	41	receptor	receptor	NOUN
admet-2874	201	42	beta	beta	NOUN
admet-2874	201	43	(	(	PUNCT
admet-2874	201	44	pdgfrβ	pdgfrβ	NOUN
admet-2874	201	45	)	)	PUNCT
admet-2874	201	46	,	,	PUNCT
admet-2874	201	47	which	which	PRON
admet-2874	201	48	is	be	AUX
admet-2874	201	49	overexpressed	overexpresse	VERB
admet-2874	201	50	on	on	ADP
admet-2874	201	51	activated	activate	VERB
admet-2874	201	52	hepatic	hepatic	ADJ
admet-2874	201	53	stellate	stellate	ADJ
admet-2874	201	54	cells	cell	NOUN
admet-2874	201	55	(	(	PUNCT
admet-2874	201	56	ahscs	ahsc	NOUN
admet-2874	201	57	)	)	PUNCT
admet-2874	201	58	.	.	PUNCT
admet-2874	202	1	this	this	DET
admet-2874	202	2	target	target	NOUN
admet-2874	202	3	was	be	AUX
admet-2874	202	4	identified	identify	VERB
admet-2874	202	5	through	through	ADP
admet-2874	202	6	an	an	DET
admet-2874	202	7	analysis	analysis	NOUN
admet-2874	202	8	of	of	ADP
admet-2874	202	9	previously	previously	ADV
admet-2874	202	10	published	publish	VERB
admet-2874	202	11	differential	differential	NOUN
admet-2874	202	12	cell	cell	NOUN
admet-2874	202	13	expression	expression	NOUN
admet-2874	202	14	data	datum	NOUN
admet-2874	202	15	and	and	CCONJ
admet-2874	202	16	single	single	ADJ
admet-2874	202	17	-	-	PUNCT
admet-2874	202	18	cell	cell	NOUN
admet-2874	202	19	rna	rna	NOUN
admet-2874	202	20	expression	expression	NOUN
admet-2874	202	21	data	datum	NOUN
admet-2874	202	22	,	,	PUNCT
admet-2874	202	23	utilising	utilise	VERB
admet-2874	202	24	in	in	ADP
admet-2874	202	25	silico	silico	NOUN
admet-2874	202	26	methods	method	NOUN
admet-2874	202	27	[	[	X
admet-2874	202	28	116	116	X
admet-2874	202	29	]	]	PUNCT
admet-2874	202	30	.	.	PUNCT
admet-2874	203	1	the	the	DET
admet-2874	203	2	investigators	investigator	NOUN
admet-2874	203	3	successfully	successfully	ADV
admet-2874	203	4	functionalized	functionalize	VERB
admet-2874	203	5	msc	msc	PROPN
admet-2874	203	6	membranes	membrane	NOUN
admet-2874	203	7	[	[	X
admet-2874	203	8	116	116	X
admet-2874	203	9	]	]	PUNCT
admet-2874	203	10	with	with	ADP
admet-2874	203	11	the	the	DET
admet-2874	203	12	ppb	ppb	NOUN
admet-2874	203	13	peptide	peptide	NOUN
admet-2874	203	14	via	via	ADP
admet-2874	203	15	hydrophobic	hydrophobic	NOUN
admet-2874	203	16	insertion	insertion	NOUN
admet-2874	203	17	,	,	PUNCT
admet-2874	203	18	a	a	DET
admet-2874	203	19	rapid	rapid	ADJ
admet-2874	203	20	and	and	CCONJ
admet-2874	203	21	clinically	clinically	ADV
admet-2874	203	22	amenable	amenable	ADJ
admet-2874	203	23	technique	technique	NOUN
admet-2874	203	24	that	that	PRON
admet-2874	203	25	preserves	preserve	VERB
admet-2874	203	26	viability	viability	NOUN
admet-2874	203	27	,	,	PUNCT
admet-2874	203	28	cellular	cellular	ADJ
admet-2874	203	29	membrane	membrane	NOUN
admet-2874	203	30	integrity	integrity	NOUN
admet-2874	203	31	,	,	PUNCT
admet-2874	203	32	and	and	CCONJ
admet-2874	203	33	functionality	functionality	NOUN
admet-2874	203	34	.	.	PUNCT
admet-2874	204	1	notably	notably	ADV
admet-2874	204	2	,	,	PUNCT
admet-2874	204	3	in	in	ADP
admet-2874	204	4	vitro	vitro	X
admet-2874	204	5	and	and	CCONJ
admet-2874	204	6	in	in	ADP
admet-2874	204	7	vivo	vivo	ADJ
admet-2874	204	8	analyses	analysis	NOUN
admet-2874	204	9	revealed	reveal	VERB
admet-2874	204	10	a	a	DET
admet-2874	204	11	significantly	significantly	ADV
admet-2874	204	12	enhanced	enhanced	ADJ
admet-2874	204	13	binding	bind	VERB
admet-2874	204	14	affinity	affinity	NOUN
admet-2874	204	15	of	of	ADP
admet-2874	204	16	ppb	ppb	NOUN
admet-2874	204	17	-	-	PUNCT
admet-2874	204	18	mscs	msc	NOUN
admet-2874	204	19	for	for	ADP
admet-2874	204	20	ahscs	ahsc	NOUN
admet-2874	204	21	compared	compare	VERB
admet-2874	204	22	to	to	ADP
admet-2874	204	23	unmodified	unmodified	ADJ
admet-2874	204	24	mscs	msc	NOUN
admet-2874	204	25	.	.	PUNCT
admet-2874	205	1	the	the	DET
admet-2874	205	2	group	group	NOUN
admet-2874	205	3	also	also	ADV
admet-2874	205	4	successfully	successfully	ADV
admet-2874	205	5	demonstrated	demonstrate	VERB
admet-2874	205	6	therapeutic	therapeutic	ADJ
admet-2874	205	7	efficacy	efficacy	NOUN
admet-2874	205	8	in	in	ADP
admet-2874	205	9	a	a	DET
admet-2874	205	10	murine	murine	ADJ
admet-2874	205	11	model	model	NOUN
admet-2874	205	12	of	of	ADP
admet-2874	205	13	liver	liver	NOUN
admet-2874	205	14	fibrosis	fibrosis	NOUN
admet-2874	205	15	,	,	PUNCT
admet-2874	205	16	indicated	indicate	VERB
admet-2874	205	17	by	by	ADP
admet-2874	205	18	marked	mark	VERB
admet-2874	205	19	[	[	X
admet-2874	205	20	116	116	NUM
admet-2874	205	21	]	]	X
admet-2874	205	22	improvements	improvement	NOUN
admet-2874	205	23	in	in	ADP
admet-2874	205	24	liver	liver	NOUN
admet-2874	205	25	histopathology	histopathology	NOUN
admet-2874	205	26	and	and	CCONJ
admet-2874	205	27	a	a	DET
admet-2874	205	28	significant	significant	ADJ
admet-2874	205	29	reduction	reduction	NOUN
admet-2874	205	30	in	in	ADP
admet-2874	205	31	serum	serum	NOUN
admet-2874	205	32	levels	level	NOUN
admet-2874	205	33	of	of	ADP
admet-2874	205	34	hepatic	hepatic	ADJ
admet-2874	205	35	injury	injury	NOUN
admet-2874	205	36	biomarkers	biomarker	NOUN
admet-2874	205	37	(	(	PUNCT
admet-2874	205	38	alanine	alanine	NOUN
admet-2874	205	39	aminotransferase	aminotransferase	NOUN
admet-2874	205	40	,	,	PUNCT
admet-2874	205	41	aspartate	aspartate	NOUN
admet-2874	205	42	aminotransferase	aminotransferase	NOUN
admet-2874	205	43	,	,	PUNCT
admet-2874	205	44	and	and	CCONJ
admet-2874	205	45	alkaline	alkaline	NOUN
admet-2874	205	46	https://biorender.com/obrtwsc	https://biorender.com/obrtwsc	X
admet-2874	205	47	admet	admet	PROPN
admet-2874	205	48	&	&	CCONJ
admet-2874	205	49	dmpk	dmpk	PROPN
admet-2874	205	50	13(4	13(4	NUM
admet-2874	205	51	)	)	PUNCT
admet-2874	205	52	(	(	PUNCT
admet-2874	205	53	2025	2025	NUM
admet-2874	205	54	)	)	PUNCT
admet-2874	205	55	2874	2874	NUM
admet-2874	205	56	hscs	hsc	NOUN
admet-2874	205	57	in	in	ADP
admet-2874	205	58	liver	liver	NOUN
admet-2874	205	59	fibrosis	fibrosis	NOUN
admet-2874	205	60	:	:	PUNCT
admet-2874	205	61	therapeutic	therapeutic	ADJ
admet-2874	205	62	advances	advance	NOUN
admet-2874	205	63	doi	doi	NOUN
admet-2874	205	64	:	:	PUNCT
admet-2874	205	65	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	205	66	11	11	NUM
admet-2874	205	67	phosphatase	phosphatase	NOUN
admet-2874	205	68	)	)	PUNCT
admet-2874	205	69	,	,	PUNCT
admet-2874	205	70	attenuated	attenuate	VERB
admet-2874	205	71	extracellular	extracellular	ADJ
admet-2874	205	72	matrix	matrix	NOUN
admet-2874	205	73	(	(	PUNCT
admet-2874	205	74	ecm	ecm	NOUN
admet-2874	205	75	)	)	PUNCT
admet-2874	205	76	deposition	deposition	NOUN
admet-2874	205	77	and	and	CCONJ
admet-2874	205	78	reduce	reduce	VERB
admet-2874	205	79	the	the	DET
admet-2874	205	80	population	population	NOUN
admet-2874	205	81	of	of	ADP
admet-2874	205	82	α	α	PROPN
admet-2874	205	83	-	-	PUNCT
admet-2874	205	84	smapositive	smapositive	ADJ
admet-2874	205	85	ahscs	ahsc	NOUN
admet-2874	205	86	compared	compare	VERB
admet-2874	205	87	to	to	ADP
admet-2874	205	88	unmodified	unmodified	ADJ
admet-2874	205	89	mscs	msc	NOUN
admet-2874	205	90	,	,	PUNCT
admet-2874	205	91	corroborating	corroborate	VERB
admet-2874	205	92	in	in	ADP
admet-2874	205	93	vitro	vitro	X
admet-2874	205	94	findings	finding	NOUN
admet-2874	205	95	indicative	indicative	ADJ
admet-2874	205	96	of	of	ADP
admet-2874	205	97	inhibited	inhibit	VERB
admet-2874	205	98	hsc	hsc	NOUN
admet-2874	205	99	activation	activation	NOUN
admet-2874	205	100	.	.	PUNCT
admet-2874	206	1	ppb	ppb	NOUN
admet-2874	206	2	-	-	PUNCT
admet-2874	206	3	mscs	msc	NOUN
admet-2874	206	4	restored	restore	VERB
admet-2874	206	5	mitochondrial	mitochondrial	ADJ
admet-2874	206	6	ultrastructure	ultrastructure	NOUN
admet-2874	206	7	in	in	ADP
admet-2874	206	8	fibrotic	fibrotic	ADJ
admet-2874	206	9	hepatocytes	hepatocyte	NOUN
admet-2874	206	10	,	,	PUNCT
admet-2874	206	11	suggesting	suggest	VERB
admet-2874	206	12	a	a	DET
admet-2874	206	13	potential	potential	ADJ
admet-2874	206	14	mechanism	mechanism	NOUN
admet-2874	206	15	involving	involve	VERB
admet-2874	206	16	mitochondrial	mitochondrial	ADJ
admet-2874	206	17	transfer	transfer	NOUN
admet-2874	206	18	.	.	PUNCT
admet-2874	207	1	in	in	ADP
admet-2874	207	2	other	other	ADJ
admet-2874	207	3	reported	report	VERB
admet-2874	207	4	research	research	NOUN
admet-2874	207	5	both	both	CCONJ
admet-2874	207	6	passive	passive	ADJ
admet-2874	207	7	(	(	PUNCT
admet-2874	207	8	ultrasound	ultrasound	NOUN
admet-2874	207	9	mediated	mediate	VERB
admet-2874	207	10	ecm	ecm	NOUN
admet-2874	207	11	degradation	degradation	NOUN
admet-2874	207	12	)	)	PUNCT
admet-2874	207	13	and	and	CCONJ
admet-2874	207	14	active	active	ADJ
admet-2874	207	15	targeting	targeting	NOUN
admet-2874	207	16	(	(	PUNCT
admet-2874	207	17	hyaluronic	hyaluronic	ADJ
admet-2874	207	18	acid	acid	NOUN
admet-2874	207	19	modification	modification	NOUN
admet-2874	207	20	)	)	PUNCT
admet-2874	207	21	were	be	AUX
admet-2874	207	22	utilized	utilize	VERB
admet-2874	207	23	to	to	PART
admet-2874	207	24	develop	develop	VERB
admet-2874	207	25	porous	porous	ADJ
admet-2874	207	26	coordination	coordination	NOUN
admet-2874	207	27	network	network	NOUN
admet-2874	207	28	nanoparticles	nanoparticle	NOUN
admet-2874	207	29	(	(	PUNCT
admet-2874	207	30	pcn	pcn	PROPN
admet-2874	207	31	-	-	PUNCT
admet-2874	207	32	nps	nps	PROPN
admet-2874	207	33	)	)	PUNCT
admet-2874	207	34	remodel	remodel	VERB
admet-2874	207	35	the	the	DET
admet-2874	207	36	ecm	ecm	PROPN
admet-2874	207	37	under	under	ADP
admet-2874	207	38	ultrasound	ultrasound	NOUN
admet-2874	207	39	,	,	PUNCT
admet-2874	207	40	enhancing	enhance	VERB
admet-2874	207	41	drug	drug	NOUN
admet-2874	207	42	access	access	NOUN
admet-2874	207	43	to	to	ADP
admet-2874	207	44	activated	activate	VERB
admet-2874	207	45	hepatic	hepatic	ADJ
admet-2874	207	46	stellate	stellate	ADJ
admet-2874	207	47	cells	cell	NOUN
admet-2874	207	48	(	(	PUNCT
admet-2874	207	49	ahscs	ahsc	NOUN
admet-2874	207	50	)	)	PUNCT
admet-2874	207	51	delivering	deliver	VERB
admet-2874	207	52	v-9302	v-9302	PROPN
admet-2874	207	53	(	(	PUNCT
admet-2874	207	54	glutamine	glutamine	NOUN
admet-2874	207	55	metabolism	metabolism	NOUN
admet-2874	207	56	inhibitor	inhibitor	NOUN
admet-2874	207	57	)	)	PUNCT
admet-2874	207	58	lead	lead	VERB
admet-2874	207	59	to	to	ADP
admet-2874	207	60	resolution	resolution	NOUN
admet-2874	207	61	of	of	ADP
admet-2874	207	62	fibrosis	fibrosis	NOUN
admet-2874	207	63	by	by	ADP
admet-2874	207	64	disrupting	disrupt	VERB
admet-2874	207	65	hepatocyte	hepatocyte	NOUN
admet-2874	207	66	-	-	PUNCT
admet-2874	207	67	hsc	hsc	NOUN
admet-2874	207	68	pro	pro	ADJ
admet-2874	207	69	-	-	ADJ
admet-2874	207	70	inflammatory	inflammatory	ADJ
admet-2874	207	71	crosstalk	crosstalk	NOUN
admet-2874	207	72	[	[	X
admet-2874	207	73	117	117	NUM
admet-2874	207	74	]	]	PUNCT
admet-2874	207	75	.	.	PUNCT
admet-2874	208	1	in	in	ADP
admet-2874	208	2	another	another	DET
admet-2874	208	3	study	study	NOUN
admet-2874	208	4	[	[	X
admet-2874	208	5	119	119	NUM
admet-2874	208	6	]	]	X
admet-2874	208	7	,	,	PUNCT
admet-2874	208	8	a	a	DET
admet-2874	208	9	multi	multi	ADJ
admet-2874	208	10	-	-	ADJ
admet-2874	208	11	target	target	ADJ
admet-2874	208	12	approach	approach	NOUN
admet-2874	208	13	,	,	PUNCT
admet-2874	208	14	a	a	DET
admet-2874	208	15	nanocarrier	nanocarrier	NOUN
admet-2874	208	16	composed	compose	VERB
admet-2874	208	17	of	of	ADP
admet-2874	208	18	circular	circular	ADJ
admet-2874	208	19	spherical	spherical	ADJ
admet-2874	208	20	dna	dna	NOUN
admet-2874	208	21	(	(	PUNCT
admet-2874	208	22	csna	csna	PROPN
admet-2874	208	23	)	)	PUNCT
admet-2874	208	24	with	with	ADP
admet-2874	208	25	surface	surface	NOUN
admet-2874	208	26	decoration	decoration	NOUN
admet-2874	208	27	of	of	ADP
admet-2874	208	28	circular	circular	ADJ
admet-2874	208	29	pdgf	pdgf	NOUN
admet-2874	208	30	-	-	PUNCT
admet-2874	208	31	bb	bb	NOUN
admet-2874	208	32	aptamer	aptamer	NOUN
admet-2874	208	33	(	(	PUNCT
admet-2874	208	34	a	a	DET
admet-2874	208	35	nuclease	nuclease	NOUN
admet-2874	208	36	-	-	PUNCT
admet-2874	208	37	resistant	resistant	ADJ
admet-2874	208	38	aptamer	aptamer	NOUN
admet-2874	208	39	blocking	block	VERB
admet-2874	208	40	pdgfbb	pdgfbb	NOUN
admet-2874	208	41	/	/	SYM
admet-2874	208	42	pdgfr	pdgfr	ADJ
admet-2874	208	43	-	-	PUNCT
admet-2874	208	44	β	β	NOUN
admet-2874	208	45	signal	signal	NOUN
admet-2874	208	46	)	)	PUNCT
admet-2874	208	47	and	and	CCONJ
admet-2874	208	48	core	core	NOUN
admet-2874	208	49	composed	compose	VERB
admet-2874	208	50	of	of	ADP
admet-2874	208	51	collagenase	collagenase	NOUN
admet-2874	208	52	i	i	PROPN
admet-2874	208	53	and	and	CCONJ
admet-2874	208	54	ml290	ml290	PROPN
admet-2874	208	55	(	(	PUNCT
admet-2874	208	56	for	for	ADP
admet-2874	208	57	reprogramming	reprogramme	VERB
admet-2874	208	58	of	of	ADP
admet-2874	208	59	pro	pro	ADJ
admet-2874	208	60	-	-	ADJ
admet-2874	208	61	fibrogenic	fibrogenic	ADJ
admet-2874	208	62	into	into	ADP
admet-2874	208	63	pro	pro	ADJ
admet-2874	208	64	-	-	ADJ
admet-2874	208	65	resolution	resolution	ADJ
admet-2874	208	66	macrophages	macrophage	NOUN
admet-2874	208	67	by	by	ADP
admet-2874	208	68	activating	activate	VERB
admet-2874	208	69	rxfp1	rxfp1	NOUN
admet-2874	208	70	signalling	signal	VERB
admet-2874	208	71	)	)	PUNCT
admet-2874	208	72	.	.	PUNCT
admet-2874	209	1	the	the	DET
admet-2874	209	2	csna	csna	PROPN
admet-2874	209	3	releases	release	NOUN
admet-2874	209	4	collagenase	collagenase	VERB
admet-2874	209	5	i	i	PRON
admet-2874	209	6	in	in	ADP
admet-2874	209	7	fibrotic	fibrotic	ADJ
admet-2874	209	8	liver	liver	NOUN
admet-2874	209	9	to	to	PART
admet-2874	209	10	degrade	degrade	VERB
admet-2874	209	11	collagen	collagen	NOUN
admet-2874	209	12	and	and	CCONJ
admet-2874	209	13	enhance	enhance	VERB
admet-2874	209	14	nanoparticle	nanoparticle	NOUN
admet-2874	209	15	penetration	penetration	NOUN
admet-2874	209	16	.	.	PUNCT
admet-2874	210	1	the	the	DET
admet-2874	210	2	csna	csna	PROPN
admet-2874	210	3	enables	enable	VERB
admet-2874	210	4	both	both	PRON
admet-2874	210	5	upstream	upstream	ADJ
admet-2874	210	6	disease	disease	NOUN
admet-2874	210	7	blockade	blockade	NOUN
admet-2874	210	8	and	and	CCONJ
admet-2874	210	9	downstream	downstream	ADJ
admet-2874	210	10	tissue	tissue	NOUN
admet-2874	210	11	restoration	restoration	NOUN
admet-2874	210	12	,	,	PUNCT
admet-2874	210	13	offering	offer	VERB
admet-2874	210	14	a	a	DET
admet-2874	210	15	novel	novel	ADJ
admet-2874	210	16	therapeutic	therapeutic	ADJ
admet-2874	210	17	approach	approach	NOUN
admet-2874	210	18	for	for	ADP
admet-2874	210	19	fibrosis	fibrosis	NOUN
admet-2874	210	20	[	[	X
admet-2874	210	21	119	119	NUM
admet-2874	210	22	]	]	PUNCT
admet-2874	210	23	.	.	PUNCT
admet-2874	211	1	table	table	NOUN
admet-2874	211	2	3	3	NUM
admet-2874	211	3	.	.	PUNCT
admet-2874	212	1	experimental	experimental	ADJ
admet-2874	212	2	approaches	approach	NOUN
admet-2874	212	3	for	for	ADP
admet-2874	212	4	active	active	ADJ
admet-2874	212	5	targeting	targeting	NOUN
admet-2874	212	6	of	of	ADP
admet-2874	212	7	liver	liver	NOUN
admet-2874	212	8	fibrosis	fibrosis	NOUN
admet-2874	212	9	molecular	molecular	ADJ
admet-2874	212	10	targets	target	NOUN
admet-2874	212	11	/	/	SYM
admet-2874	212	12	receptors	receptor	NOUN
admet-2874	212	13	targeting	target	VERB
admet-2874	212	14	ligand	ligand	ADJ
admet-2874	212	15	carrier	carrier	NOUN
admet-2874	212	16	drug	drug	NOUN
admet-2874	212	17	outcomes	outcome	NOUN
admet-2874	212	18	ref	ref	VERB
admet-2874	212	19	.	.	PUNCT
admet-2874	213	1	pdgfr	pdgfr	ADJ
admet-2874	213	2	-	-	PUNCT
admet-2874	213	3	β	β	NOUN
admet-2874	213	4	/	/	SYM
admet-2874	213	5	rars	rar	NOUN
admet-2874	213	6	vitamin	vitamin	VERB
admet-2874	213	7	a	a	DET
admet-2874	213	8	(	(	PUNCT
admet-2874	213	9	va	va	NOUN
admet-2874	213	10	)	)	PUNCT
admet-2874	213	11	nanopolyplex	nanopolyplex	ADJ
admet-2874	213	12	sipdgfr	sipdgfr	NOUN
admet-2874	213	13	-	-	PUNCT
admet-2874	213	14	β	β	PROPN
admet-2874	213	15	sirna	sirna	PROPN
admet-2874	213	16	inhibited	inhibit	VERB
admet-2874	213	17	hsc	hsc	NOUN
admet-2874	213	18	activation	activation	NOUN
admet-2874	213	19	;	;	PUNCT
admet-2874	213	20	↓	↓	NOUN
admet-2874	213	21	pro	pro	ADJ
admet-2874	213	22	-	-	ADJ
admet-2874	213	23	fibrogenic	fibrogenic	ADJ
admet-2874	213	24	proteins	protein	NOUN
admet-2874	213	25	and	and	CCONJ
admet-2874	213	26	hepatic	hepatic	ADJ
admet-2874	213	27	collagen	collagen	NOUN
admet-2874	213	28	;	;	PUNCT
admet-2874	213	29	restored	restore	VERB
admet-2874	213	30	liver	liver	NOUN
admet-2874	213	31	function	function	NOUN
admet-2874	213	32	in	in	ADP
admet-2874	213	33	mice	mouse	NOUN
admet-2874	213	34	[	[	X
admet-2874	213	35	120	120	NUM
admet-2874	213	36	]	]	PUNCT
admet-2874	213	37	ecm	ecm	NOUN
admet-2874	213	38	collagenase	collagenase	PROPN
admet-2874	213	39	chitosan	chitosan	PROPN
admet-2874	213	40	nanoparticles	nanoparticle	NOUN
admet-2874	213	41	sirna	sirna	PROPN
admet-2874	213	42	enhanced	enhance	VERB
admet-2874	213	43	liver	liver	NOUN
admet-2874	213	44	uptake	uptake	NOUN
admet-2874	213	45	and	and	CCONJ
admet-2874	213	46	cellspecific	cellspecific	ADJ
admet-2874	213	47	delivery	delivery	NOUN
admet-2874	213	48	with	with	ADP
admet-2874	213	49	collagenase	collagenase	NOUN
admet-2874	213	50	pre	pre	NOUN
admet-2874	213	51	-	-	NOUN
admet-2874	213	52	treatment	treatment	NOUN
admet-2874	213	53	[	[	X
admet-2874	213	54	121	121	NUM
admet-2874	213	55	]	]	PUNCT
admet-2874	213	56	ahsc	ahsc	NOUN
admet-2874	213	57	cl15a6	cl15a6	PROPN
admet-2874	213	58	,	,	PUNCT
admet-2874	213	59	cl15h6	cl15h6	ADP
admet-2874	213	60	lipid	lipid	NOUN
admet-2874	213	61	nanoparticles	nanoparticle	NOUN
admet-2874	213	62	sirna	sirna	PROPN
admet-2874	213	63	cocktail	cocktail	NOUN
admet-2874	213	64	knockdown	knockdown	NOUN
admet-2874	213	65	of	of	ADP
admet-2874	213	66	hh	hh	PROPN
admet-2874	213	67	and	and	CCONJ
admet-2874	213	68	tgfβ1	tgfβ1	NOUN
admet-2874	213	69	reversed	reverse	VERB
admet-2874	213	70	fibrosis	fibrosis	NOUN
admet-2874	213	71	;	;	PUNCT
admet-2874	214	1	reprogrammed	reprogramme	VERB
admet-2874	214	2	ahscs	ahsc	NOUN
admet-2874	214	3	to	to	ADP
admet-2874	214	4	qhscs	qhscs	NOUN
admet-2874	214	5	[	[	X
admet-2874	214	6	122	122	NUM
admet-2874	214	7	]	]	SYM
admet-2874	214	8	hif-1α+	hif-1α+	NUM
admet-2874	214	9	hscs	hscs	ADJ
admet-2874	214	10	va	va	NOUN
admet-2874	214	11	-	-	PUNCT
admet-2874	214	12	peg	peg	NOUN
admet-2874	214	13	cn@gqds	cn@gqds	NOUN
admet-2874	214	14	nanosheets	nanosheet	NOUN
admet-2874	214	15	hif-1α	hif-1α	PROPN
admet-2874	214	16	sirna	sirna	PROPN
admet-2874	214	17	tgf	tgf	PROPN
admet-2874	214	18	-	-	PUNCT
admet-2874	214	19	β1	β1	PROPN
admet-2874	214	20	/	/	SYM
admet-2874	214	21	smad	smad	NOUN
admet-2874	214	22	inhibition	inhibition	NOUN
admet-2874	214	23	;	;	PUNCT
admet-2874	214	24	effective	effective	ADJ
admet-2874	214	25	sirna	sirna	PROPN
admet-2874	214	26	delivery	delivery	NOUN
admet-2874	214	27	under	under	ADP
admet-2874	214	28	hypoxia	hypoxia	NOUN
admet-2874	214	29	[	[	X
admet-2874	214	30	123	123	NUM
admet-2874	214	31	]	]	PUNCT
admet-2874	214	32	cxcr4	cxcr4	NOUN
admet-2874	214	33	ctce9908	ctce9908	PROPN
admet-2874	214	34	peptide	peptide	NOUN
admet-2874	214	35	silica	silica	NOUN
admet-2874	214	36	micelles	micelle	NOUN
admet-2874	214	37	silibinin	silibinin	VERB
admet-2874	214	38	+	+	CCONJ
admet-2874	214	39	sorafenib	sorafenib	PROPN
admet-2874	214	40	↓	↓	NOUN
admet-2874	214	41	inflammation	inflammation	PROPN
admet-2874	214	42	/	/	SYM
admet-2874	214	43	collagen	collagen	NOUN
admet-2874	214	44	;	;	PUNCT
admet-2874	214	45	↓	↓	PROPN
admet-2874	214	46	hsc	hsc	PROPN
admet-2874	214	47	proliferation	proliferation	NOUN
admet-2874	214	48	;	;	PUNCT
admet-2874	214	49	↑	↑	NOUN
admet-2874	214	50	apoptosis	apoptosis	NOUN
admet-2874	214	51	.	.	PUNCT
admet-2874	215	1	[	[	X
admet-2874	215	2	124	124	NUM
admet-2874	215	3	]	]	X
admet-2874	215	4	igfiir	igfiir	NOUN
admet-2874	215	5	aptamer	aptamer	NOUN
admet-2874	215	6	conjugate	conjugate	PROPN
admet-2874	215	7	sirna	sirna	PROPN
admet-2874	215	8	diagnostic	diagnostic	ADJ
admet-2874	215	9	and	and	CCONJ
admet-2874	215	10	therapeutic	therapeutic	ADJ
admet-2874	215	11	tool	tool	NOUN
admet-2874	215	12	with	with	ADP
admet-2874	215	13	high	high	ADJ
admet-2874	215	14	affinity	affinity	NOUN
admet-2874	215	15	[	[	X
admet-2874	215	16	106	106	X
admet-2874	215	17	]	]	PUNCT
admet-2874	215	18	cd44	cd44	PROPN
admet-2874	215	19	cd44	cd44	PROPN
admet-2874	215	20	rbpr	rbpr	NOUN
admet-2874	215	21	hyaluronic	hyaluronic	ADJ
admet-2874	215	22	acid	acid	NOUN
admet-2874	215	23	retinoic	retinoic	NOUN
admet-2874	215	24	acid	acid	PROPN
admet-2874	215	25	crgdyk	crgdyk	PROPN
admet-2874	215	26	nanoparticle	nanoparticle	NOUN
admet-2874	215	27	curcumin	curcumin	NOUN
admet-2874	215	28	promising	promise	VERB
admet-2874	215	29	antifibrotic	antifibrotic	ADJ
admet-2874	215	30	effect	effect	NOUN
admet-2874	215	31	via	via	ADP
admet-2874	215	32	ha	ha	ADJ
admet-2874	215	33	-	-	PUNCT
admet-2874	215	34	pla	pla	PROPN
admet-2874	215	35	nps	nps	PROPN
admet-2874	215	36	.	.	PUNCT
admet-2874	216	1	[	[	X
admet-2874	216	2	125	125	NUM
admet-2874	216	3	]	]	PUNCT
admet-2874	216	4	nanomicelles	nanomicelle	NOUN
admet-2874	216	5	silibinin	silibinin	VERB
admet-2874	216	6	strong	strong	ADJ
admet-2874	216	7	antifibrotic	antifibrotic	ADJ
admet-2874	216	8	effects	effect	NOUN
admet-2874	216	9	in	in	ADP
admet-2874	216	10	ha	ha	ADV
admet-2874	216	11	-	-	PUNCT
admet-2874	216	12	based	base	VERB
admet-2874	216	13	nanomicelles	nanomicelle	NOUN
admet-2874	216	14	[	[	X
admet-2874	216	15	126	126	NUM
admet-2874	216	16	]	]	PUNCT
admet-2874	216	17	nanoparticles	nanoparticle	NOUN
admet-2874	216	18	galangin	galangin	PROPN
admet-2874	216	19	↑	↑	PROPN
admet-2874	216	20	solubility	solubility	PROPN
admet-2874	216	21	;	;	PUNCT
admet-2874	216	22	anti	anti	ADJ
admet-2874	216	23	-	-	ADJ
admet-2874	216	24	fibrotic	fibrotic	ADJ
admet-2874	216	25	via	via	ADP
admet-2874	216	26	ra	ra	PROPN
admet-2874	216	27	targeting	target	VERB
admet-2874	216	28	[	[	X
admet-2874	216	29	127	127	NUM
admet-2874	216	30	]	]	X
admet-2874	216	31	αvβ3	αvβ3	NOUN
admet-2874	216	32	integrin	integrin	NOUN
admet-2874	216	33	liposomes	liposome	VERB
admet-2874	216	34	vismodegib	vismodegib	VERB
admet-2874	216	35	targeted	target	VERB
admet-2874	216	36	delivery	delivery	NOUN
admet-2874	216	37	to	to	AUX
admet-2874	216	38	ahscs	ahsc	NOUN
admet-2874	216	39	over	over	ADP
admet-2874	216	40	qhscs	qhscs	NOUN
admet-2874	216	41	[	[	X
admet-2874	216	42	128	128	NUM
admet-2874	216	43	]	]	PUNCT
admet-2874	216	44	lx-2	lx-2	NOUN
admet-2874	216	45	cells	cell	NOUN
admet-2874	216	46	creka	creka	VERB
admet-2874	216	47	peptide	peptide	NOUN
admet-2874	216	48	liposomes	liposome	NOUN
admet-2874	216	49	sorafenib	sorafenib	NOUN
admet-2874	216	50	reduced	reduce	VERB
admet-2874	216	51	ecm	ecm	NOUN
admet-2874	216	52	and	and	CCONJ
admet-2874	216	53	hsc	hsc	NOUN
admet-2874	216	54	activation	activation	NOUN
admet-2874	216	55	[	[	X
admet-2874	216	56	129	129	NUM
admet-2874	216	57	]	]	PUNCT
admet-2874	216	58	rars	rar	NOUN
admet-2874	216	59	vitamin	vitamin	VERB
admet-2874	216	60	a	a	DET
admet-2874	216	61	cationic	cationic	ADJ
admet-2874	216	62	liposomes	liposome	NOUN
admet-2874	216	63	tlr4	tlr4	PROPN
admet-2874	216	64	shrna	shrna	PROPN
admet-2874	216	65	effective	effective	ADJ
admet-2874	216	66	ahsc	ahsc	NOUN
admet-2874	216	67	targeting	targeting	NOUN
admet-2874	216	68	;	;	PUNCT
admet-2874	216	69	antifibrotic	antifibrotic	ADJ
admet-2874	216	70	outcome	outcome	NOUN
admet-2874	216	71	[	[	X
admet-2874	216	72	130	130	NUM
admet-2874	216	73	]	]	PUNCT
admet-2874	216	74	pdgf	pdgf	NOUN
admet-2874	216	75	+	+	CCONJ
admet-2874	216	76	tgfβ	tgfβ	ADJ
admet-2874	216	77	vitamin	vitamin	NOUN
admet-2874	216	78	a	a	DET
admet-2874	216	79	liposomes	liposome	NOUN
admet-2874	216	80	imatinib	imatinib	NOUN
admet-2874	216	81	better	well	ADJ
admet-2874	216	82	antifibrotic	antifibrotic	ADJ
admet-2874	216	83	effects	effect	NOUN
admet-2874	216	84	with	with	ADP
admet-2874	216	85	va	va	NOUN
admet-2874	216	86	-	-	NOUN
admet-2874	216	87	conjugation	conjugation	NOUN
admet-2874	216	88	[	[	X
admet-2874	216	89	131	131	NUM
admet-2874	216	90	]	]	X
admet-2874	216	91	ros	ros	PROPN
admet-2874	216	92	crgd	crgd	PROPN
admet-2874	216	93	micelles	micelle	NOUN
admet-2874	216	94	resveratrol	resveratrol	VERB
admet-2874	216	95	ros	ros	PROPN
admet-2874	216	96	-	-	PUNCT
admet-2874	216	97	responsive	responsive	ADJ
admet-2874	216	98	release	release	NOUN
admet-2874	216	99	in	in	ADP
admet-2874	216	100	ahscs	ahsc	NOUN
admet-2874	216	101	[	[	X
admet-2874	216	102	132	132	NUM
admet-2874	216	103	]	]	PUNCT
admet-2874	216	104	m6p	m6p	NOUN
admet-2874	216	105	/	/	SYM
admet-2874	216	106	igf	igf	PROPN
admet-2874	216	107	-	-	PUNCT
admet-2874	216	108	ii	ii	NOUN
admet-2874	216	109	receptor	receptor	NOUN
admet-2874	216	110	m6p	m6p	NOUN
admet-2874	216	111	-	-	ADJ
admet-2874	216	112	albumin	albumin	ADJ
admet-2874	216	113	liposomes	liposome	NOUN
admet-2874	216	114	hesperidin	hesperidin	VERB
admet-2874	216	115	↑	↑	PROPN
admet-2874	216	116	targeting	target	VERB
admet-2874	216	117	;	;	PUNCT
admet-2874	216	118	↓	↓	PROPN
admet-2874	216	119	required	require	VERB
admet-2874	216	120	dose	dose	NOUN
admet-2874	216	121	.	.	PUNCT
admet-2874	217	1	[	[	X
admet-2874	217	2	133	133	NUM
admet-2874	217	3	]	]	SYM
admet-2874	217	4	ga	ga	NOUN
admet-2874	217	5	receptor	receptor	NOUN
admet-2874	217	6	+	+	CCONJ
admet-2874	217	7	cd44	cd44	PROPN
admet-2874	217	8	ga	ga	NOUN
admet-2874	218	1	+	+	CCONJ
admet-2874	218	2	ha	ha	INTJ
admet-2874	218	3	liposomes	liposomes	PROPN
admet-2874	218	4	curcumin	curcumin	VERB
admet-2874	218	5	+	+	CCONJ
admet-2874	218	6	berberine	berberine	NOUN
admet-2874	218	7	synergistic	synergistic	ADJ
admet-2874	218	8	anti	anti	ADJ
admet-2874	218	9	-	-	ADJ
admet-2874	218	10	ahsc	ahsc	ADJ
admet-2874	218	11	and	and	CCONJ
admet-2874	218	12	proapoptotic	proapoptotic	ADJ
admet-2874	218	13	effect	effect	NOUN
admet-2874	218	14	[	[	X
admet-2874	218	15	134	134	NUM
admet-2874	218	16	]	]	PUNCT
admet-2874	218	17	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	218	18	a.	a.	NOUN
admet-2874	218	19	singh	singh	PROPN
admet-2874	218	20	et	et	PROPN
admet-2874	218	21	al	al	PROPN
admet-2874	218	22	.	.	PROPN
admet-2874	218	23	admet	admet	PROPN
admet-2874	218	24	&	&	CCONJ
admet-2874	218	25	dmpk	dmpk	PROPN
admet-2874	218	26	13(4	13(4	NUM
admet-2874	218	27	)	)	PUNCT
admet-2874	218	28	(	(	PUNCT
admet-2874	218	29	2025	2025	NUM
admet-2874	218	30	)	)	PUNCT
admet-2874	218	31	2874	2874	NUM
admet-2874	218	32	12	12	NUM
admet-2874	218	33	molecular	molecular	ADJ
admet-2874	218	34	targets	target	NOUN
admet-2874	218	35	/	/	SYM
admet-2874	218	36	receptors	receptor	NOUN
admet-2874	218	37	targeting	target	VERB
admet-2874	218	38	ligand	ligand	ADJ
admet-2874	218	39	carrier	carrier	NOUN
admet-2874	218	40	drug	drug	NOUN
admet-2874	218	41	outcomes	outcome	NOUN
admet-2874	218	42	ref	ref	VERB
admet-2874	218	43	.	.	PUNCT
admet-2874	219	1	rars	rar	NOUN
admet-2874	219	2	+	+	CCONJ
admet-2874	219	3	rxrs	rxrs	NOUN
admet-2874	219	4	vitamin	vitamin	VERB
admet-2874	219	5	a	a	DET
admet-2874	219	6	liposomes	liposome	NOUN
admet-2874	219	7	+	+	CCONJ
admet-2874	219	8	exosomes	exosome	NOUN
admet-2874	219	9	hydroxychloroquine	hydroxychloroquine	PROPN
admet-2874	219	10	hybrid	hybrid	NOUN
admet-2874	219	11	system	system	NOUN
admet-2874	219	12	effectively	effectively	ADV
admet-2874	219	13	targets	target	VERB
admet-2874	219	14	fibrosis	fibrosis	NOUN
admet-2874	219	15	[	[	X
admet-2874	219	16	135	135	NUM
admet-2874	219	17	]	]	X
admet-2874	219	18	cxcr4	cxcr4	NOUN
admet-2874	219	19	amd3100	amd3100	PROPN
admet-2874	219	20	liposomes	liposomes	PROPN
admet-2874	219	21	pirfenidone	pirfenidone	PROPN
admet-2874	219	22	↓	↓	PROPN
admet-2874	219	23	cxcr4	cxcr4	PROPN
admet-2874	219	24	,	,	PUNCT
admet-2874	219	25	tgfβ	tgfβ	ADJ
admet-2874	219	26	,	,	PUNCT
admet-2874	219	27	α	α	X
admet-2874	219	28	-	-	PUNCT
admet-2874	219	29	sma	sma	NOUN
admet-2874	219	30	;	;	PUNCT
admet-2874	219	31	effective	effective	ADJ
admet-2874	219	32	antifibrotic	antifibrotic	ADJ
admet-2874	219	33	response	response	NOUN
admet-2874	219	34	[	[	X
admet-2874	219	35	136	136	NUM
admet-2874	219	36	]	]	PUNCT
admet-2874	219	37	hscs	hsc	NOUN
admet-2874	219	38	sparc	sparc	NOUN
admet-2874	219	39	receptor	receptor	NOUN
admet-2874	219	40	collagenase	collagenase	NOUN
admet-2874	220	1	i	i	PRON
admet-2874	220	2	+	+	CCONJ
admet-2874	220	3	retinol	retinol	NOUN
admet-2874	220	4	albumin	albumin	NOUN
admet-2874	220	5	nanodrill	nanodrill	NOUN
admet-2874	220	6	micelles	micelle	VERB
admet-2874	220	7	nilotinib	nilotinib	NOUN
admet-2874	220	8	deep	deep	ADJ
admet-2874	220	9	tissue	tissue	NOUN
admet-2874	220	10	penetration	penetration	NOUN
admet-2874	220	11	;	;	PUNCT
admet-2874	220	12	strong	strong	ADJ
admet-2874	220	13	antifibrotic	antifibrotic	ADJ
admet-2874	220	14	effect	effect	NOUN
admet-2874	220	15	[	[	X
admet-2874	220	16	80	80	NUM
admet-2874	220	17	]	]	PUNCT
admet-2874	220	18	nanocrystals	nanocrystal	NOUN
admet-2874	220	19	silibinin	silibinin	VERB
admet-2874	220	20	high	high	ADJ
admet-2874	220	21	bioavailability	bioavailability	NOUN
admet-2874	220	22	;	;	PUNCT
admet-2874	220	23	pdi	pdi	X
admet-2874	220	24	<	<	X
admet-2874	220	25	0.15	0.15	NUM
admet-2874	220	26	;	;	PUNCT
admet-2874	220	27	60	60	PROPN
admet-2874	220	28	nm	nm	NOUN
admet-2874	220	29	[	[	X
admet-2874	220	30	137	137	NUM
admet-2874	220	31	]	]	X
admet-2874	220	32	pdgfr	pdgfr	NOUN
admet-2874	220	33	-	-	PUNCT
admet-2874	220	34	β	β	NOUN
admet-2874	220	35	/	/	SYM
admet-2874	220	36	rars	rar	NOUN
admet-2874	220	37	vitamin	vitamin	VERB
admet-2874	220	38	a	a	DET
admet-2874	220	39	(	(	PUNCT
admet-2874	220	40	va	va	NOUN
admet-2874	220	41	)	)	PUNCT
admet-2874	220	42	nanopolyplex	nanopolyplex	ADJ
admet-2874	220	43	sipdgfr	sipdgfr	NOUN
admet-2874	220	44	-	-	PUNCT
admet-2874	220	45	β	β	PROPN
admet-2874	220	46	sirna	sirna	PROPN
admet-2874	220	47	inhibited	inhibit	VERB
admet-2874	220	48	hsc	hsc	NOUN
admet-2874	220	49	activation	activation	NOUN
admet-2874	220	50	;	;	PUNCT
admet-2874	220	51	↓	↓	NOUN
admet-2874	220	52	pro	pro	ADJ
admet-2874	220	53	-	-	ADJ
admet-2874	220	54	fibrogenic	fibrogenic	ADJ
admet-2874	220	55	proteins	protein	NOUN
admet-2874	220	56	and	and	CCONJ
admet-2874	220	57	hepatic	hepatic	ADJ
admet-2874	220	58	collagen	collagen	NOUN
admet-2874	220	59	;	;	PUNCT
admet-2874	220	60	restored	restore	VERB
admet-2874	220	61	liver	liver	NOUN
admet-2874	220	62	function	function	NOUN
admet-2874	220	63	in	in	ADP
admet-2874	220	64	mice	mouse	NOUN
admet-2874	220	65	[	[	X
admet-2874	220	66	138	138	NUM
admet-2874	220	67	]	]	PUNCT
admet-2874	220	68	ecm	ecm	NOUN
admet-2874	220	69	collagenase	collagenase	PROPN
admet-2874	220	70	chitosan	chitosan	PROPN
admet-2874	220	71	nanoparticles	nanoparticle	NOUN
admet-2874	220	72	sirna	sirna	PROPN
admet-2874	220	73	enhanced	enhance	VERB
admet-2874	220	74	liver	liver	NOUN
admet-2874	220	75	uptake	uptake	NOUN
admet-2874	220	76	and	and	CCONJ
admet-2874	220	77	cellspecific	cellspecific	ADJ
admet-2874	220	78	delivery	delivery	NOUN
admet-2874	220	79	with	with	ADP
admet-2874	220	80	collagenase	collagenase	NOUN
admet-2874	220	81	pre	pre	NOUN
admet-2874	220	82	-	-	NOUN
admet-2874	220	83	treatment	treatment	ADJ
admet-2874	220	84	[	[	X
admet-2874	220	85	139	139	NUM
admet-2874	220	86	]	]	X
admet-2874	220	87	ahsc	ahsc	NOUN
admet-2874	220	88	cl15a6	cl15a6	PROPN
admet-2874	220	89	,	,	PUNCT
admet-2874	220	90	cl15h6	cl15h6	ADP
admet-2874	220	91	lipid	lipid	NOUN
admet-2874	220	92	nanoparticles	nanoparticle	NOUN
admet-2874	220	93	sirna	sirna	PROPN
admet-2874	220	94	cocktail	cocktail	NOUN
admet-2874	220	95	knockdown	knockdown	NOUN
admet-2874	220	96	of	of	ADP
admet-2874	220	97	hh	hh	PROPN
admet-2874	220	98	and	and	CCONJ
admet-2874	220	99	tgfβ1	tgfβ1	PROPN
admet-2874	220	100	;	;	PUNCT
admet-2874	220	101	reversed	reverse	VERB
admet-2874	220	102	fibrosis	fibrosis	NOUN
admet-2874	220	103	;	;	PUNCT
admet-2874	221	1	reprogrammed	reprogramme	VERB
admet-2874	221	2	ahscs	ahsc	NOUN
admet-2874	221	3	to	to	ADP
admet-2874	221	4	qhscs	qhscs	NOUN
admet-2874	221	5	[	[	X
admet-2874	221	6	140	140	NUM
admet-2874	221	7	]	]	SYM
admet-2874	221	8	hif-1α+	hif-1α+	NUM
admet-2874	221	9	hscs	hscs	ADJ
admet-2874	221	10	va	va	NOUN
admet-2874	221	11	-	-	PUNCT
admet-2874	221	12	peg	peg	NOUN
admet-2874	221	13	cn@gqds	cn@gqds	NOUN
admet-2874	221	14	nanosheets	nanosheet	NOUN
admet-2874	221	15	hif-1α	hif-1α	PROPN
admet-2874	221	16	sirna	sirna	PROPN
admet-2874	221	17	tgf	tgf	PROPN
admet-2874	221	18	-	-	PUNCT
admet-2874	221	19	β1	β1	PROPN
admet-2874	221	20	/	/	SYM
admet-2874	221	21	smad	smad	NOUN
admet-2874	221	22	inhibition	inhibition	NOUN
admet-2874	221	23	;	;	PUNCT
admet-2874	221	24	effective	effective	ADJ
admet-2874	221	25	sirna	sirna	PROPN
admet-2874	221	26	delivery	delivery	NOUN
admet-2874	221	27	under	under	ADP
admet-2874	221	28	hypoxia	hypoxia	NOUN
admet-2874	221	29	[	[	X
admet-2874	221	30	141	141	NUM
admet-2874	221	31	]	]	SYM
admet-2874	221	32	sparc	sparc	NOUN
admet-2874	221	33	receptor	receptor	NOUN
admet-2874	221	34	albumin	albumin	ADJ
admet-2874	221	35	albumin	albumin	NOUN
admet-2874	221	36	coated	coat	VERB
admet-2874	221	37	liposomes	liposome	NOUN
admet-2874	221	38	naringenin	naringenin	VERB
admet-2874	221	39	better	well	ADJ
admet-2874	221	40	antifibrotic	antifibrotic	ADJ
admet-2874	221	41	effects	effect	NOUN
admet-2874	221	42	in	in	ADP
admet-2874	221	43	mouse	mouse	NOUN
admet-2874	221	44	model	model	NOUN
admet-2874	221	45	[	[	X
admet-2874	221	46	142	142	NUM
admet-2874	221	47	]	]	X
admet-2874	221	48	igfiir	igfiir	NOUN
admet-2874	221	49	aptamer	aptamer	NOUN
admet-2874	221	50	conjugate	conjugate	PROPN
admet-2874	221	51	sirna	sirna	PROPN
admet-2874	221	52	diagnostic	diagnostic	ADJ
admet-2874	221	53	and	and	CCONJ
admet-2874	221	54	therapeutic	therapeutic	ADJ
admet-2874	221	55	tool	tool	NOUN
admet-2874	221	56	with	with	ADP
admet-2874	221	57	high	high	ADJ
admet-2874	221	58	affinity	affinity	NOUN
admet-2874	221	59	[	[	X
admet-2874	221	60	143	143	NUM
admet-2874	221	61	]	]	X
admet-2874	221	62	cd44	cd44	PROPN
admet-2874	221	63	hyaluronic	hyaluronic	ADJ
admet-2874	221	64	acid	acid	NOUN
admet-2874	221	65	nanoparticle	nanoparticle	NOUN
admet-2874	221	66	curcumin	curcumin	NOUN
admet-2874	221	67	promising	promise	VERB
admet-2874	221	68	antifibrotic	antifibrotic	ADJ
admet-2874	221	69	effect	effect	NOUN
admet-2874	221	70	via	via	ADP
admet-2874	221	71	ha	ha	PROPN
admet-2874	221	72	-	-	PUNCT
admet-2874	221	73	pla	pla	PROPN
admet-2874	221	74	nps	nps	PROPN
admet-2874	222	1	[	[	X
admet-2874	222	2	79	79	NUM
admet-2874	222	3	]	]	X
admet-2874	222	4	cd44	cd44	PROPN
admet-2874	222	5	hyaluronic	hyaluronic	ADJ
admet-2874	222	6	acid	acid	NOUN
admet-2874	222	7	nanomicelles	nanomicelle	NOUN
admet-2874	222	8	silibinin	silibinin	VERB
admet-2874	222	9	strong	strong	ADJ
admet-2874	222	10	antifibrotic	antifibrotic	ADJ
admet-2874	222	11	effects	effect	NOUN
admet-2874	222	12	in	in	ADP
admet-2874	222	13	ha	ha	ADV
admet-2874	222	14	-	-	PUNCT
admet-2874	222	15	based	base	VERB
admet-2874	222	16	nanomicelles	nanomicelle	NOUN
admet-2874	222	17	[	[	X
admet-2874	222	18	144	144	NUM
admet-2874	222	19	]	]	X
admet-2874	222	20	rbpr	rbpr	PROPN
admet-2874	222	21	retinoic	retinoic	PROPN
admet-2874	222	22	acid	acid	NOUN
admet-2874	222	23	nanoparticles	nanoparticle	NOUN
admet-2874	222	24	galangin	galangin	VERB
admet-2874	222	25	↑	↑	PROPN
admet-2874	222	26	solubility	solubility	PROPN
admet-2874	222	27	;	;	PUNCT
admet-2874	222	28	anti	anti	ADJ
admet-2874	222	29	-	-	ADJ
admet-2874	222	30	fibrotic	fibrotic	ADJ
admet-2874	222	31	via	via	ADP
admet-2874	222	32	ra	ra	PROPN
admet-2874	222	33	targeting	target	VERB
admet-2874	222	34	[	[	X
admet-2874	222	35	145	145	NUM
admet-2874	222	36	]	]	PUNCT
admet-2874	222	37	αvβ3	αvβ3	NOUN
admet-2874	222	38	integrin	integrin	PROPN
admet-2874	222	39	crgdyk	crgdyk	PROPN
admet-2874	222	40	liposomes	liposome	VERB
admet-2874	222	41	vismodegib	vismodegib	VERB
admet-2874	222	42	targeted	target	VERB
admet-2874	222	43	delivery	delivery	NOUN
admet-2874	222	44	to	to	PART
admet-2874	222	45	ahscs	ahsc	NOUN
admet-2874	222	46	over	over	ADP
admet-2874	222	47	qhscs	qhscs	NOUN
admet-2874	222	48	.	.	PUNCT
admet-2874	223	1	[	[	X
admet-2874	223	2	146	146	NUM
admet-2874	223	3	]	]	PUNCT
admet-2874	223	4	lx-2	lx-2	NOUN
admet-2874	223	5	cells	cell	NOUN
admet-2874	223	6	rars	rar	NOUN
admet-2874	223	7	creka	creka	NOUN
admet-2874	223	8	peptide	peptide	NOUN
admet-2874	223	9	liposomes	liposome	NOUN
admet-2874	223	10	sorafenib	sorafenib	NOUN
admet-2874	223	11	reduced	reduce	VERB
admet-2874	223	12	ecm	ecm	NOUN
admet-2874	223	13	and	and	CCONJ
admet-2874	223	14	hsc	hsc	NOUN
admet-2874	223	15	activation	activation	NOUN
admet-2874	223	16	[	[	X
admet-2874	223	17	124	124	NUM
admet-2874	223	18	]	]	X
admet-2874	223	19	vitamin	vitamin	NOUN
admet-2874	223	20	a	a	DET
admet-2874	223	21	cationic	cationic	ADJ
admet-2874	223	22	liposomes	liposome	NOUN
admet-2874	223	23	tlr4	tlr4	PROPN
admet-2874	223	24	shrna	shrna	PROPN
admet-2874	223	25	effective	effective	ADJ
admet-2874	223	26	ahsc	ahsc	NOUN
admet-2874	223	27	targeting	targeting	NOUN
admet-2874	223	28	;	;	PUNCT
admet-2874	223	29	antifibrotic	antifibrotic	ADJ
admet-2874	223	30	outcome	outcome	NOUN
admet-2874	224	1	[	[	X
admet-2874	224	2	147	147	NUM
admet-2874	224	3	]	]	PUNCT
admet-2874	224	4	pdgf	pdgf	NOUN
admet-2874	224	5	+	+	CCONJ
admet-2874	224	6	tgfβ	tgfβ	ADJ
admet-2874	224	7	vitamin	vitamin	NOUN
admet-2874	224	8	a	a	DET
admet-2874	224	9	liposomes	liposome	NOUN
admet-2874	224	10	imatinib	imatinib	NOUN
admet-2874	224	11	better	well	ADJ
admet-2874	224	12	antifibrotic	antifibrotic	ADJ
admet-2874	224	13	effects	effect	NOUN
admet-2874	224	14	with	with	ADP
admet-2874	224	15	va	va	NOUN
admet-2874	224	16	-	-	ADJ
admet-2874	224	17	conjugation	conjugation	NOUN
admet-2874	224	18	[	[	X
admet-2874	224	19	148	148	NUM
admet-2874	224	20	]	]	X
admet-2874	224	21	ros	ros	PROPN
admet-2874	224	22	crgd	crgd	PROPN
admet-2874	224	23	micelles	micelle	NOUN
admet-2874	224	24	resveratrol	resveratrol	VERB
admet-2874	224	25	ros	ros	PROPN
admet-2874	224	26	-	-	PUNCT
admet-2874	224	27	responsive	responsive	ADJ
admet-2874	224	28	release	release	NOUN
admet-2874	224	29	in	in	ADP
admet-2874	224	30	ahscs	ahsc	NOUN
admet-2874	224	31	.	.	PUNCT
admet-2874	225	1	[	[	X
admet-2874	225	2	149	149	NUM
admet-2874	225	3	]	]	PUNCT
admet-2874	225	4	m6p	m6p	NOUN
admet-2874	225	5	/	/	SYM
admet-2874	225	6	igf	igf	PROPN
admet-2874	225	7	-	-	PUNCT
admet-2874	225	8	ii	ii	NOUN
admet-2874	225	9	receptor	receptor	NOUN
admet-2874	225	10	m6p	m6p	NOUN
admet-2874	225	11	-	-	ADJ
admet-2874	225	12	albumin	albumin	ADJ
admet-2874	225	13	liposomes	liposome	NOUN
admet-2874	225	14	hesperidin	hesperidin	VERB
admet-2874	225	15	↑	↑	PROPN
admet-2874	225	16	targeting	target	VERB
admet-2874	225	17	;	;	PUNCT
admet-2874	225	18	↓	↓	PROPN
admet-2874	225	19	required	require	VERB
admet-2874	225	20	dose	dose	NOUN
admet-2874	225	21	.	.	PUNCT
admet-2874	226	1	[	[	X
admet-2874	226	2	150	150	NUM
admet-2874	226	3	]	]	PUNCT
admet-2874	226	4	ga	ga	NOUN
admet-2874	226	5	receptor	receptor	NOUN
admet-2874	226	6	+	+	CCONJ
admet-2874	226	7	cd44	cd44	PROPN
admet-2874	226	8	ga	ga	NOUN
admet-2874	227	1	+	+	CCONJ
admet-2874	227	2	ha	ha	INTJ
admet-2874	227	3	liposomes	liposomes	PROPN
admet-2874	227	4	curcumin	curcumin	VERB
admet-2874	227	5	+	+	CCONJ
admet-2874	227	6	berberine	berberine	NOUN
admet-2874	227	7	synergistic	synergistic	ADJ
admet-2874	227	8	anti	anti	ADJ
admet-2874	227	9	-	-	ADJ
admet-2874	227	10	ahsc	ahsc	ADJ
admet-2874	227	11	and	and	CCONJ
admet-2874	227	12	proapoptotic	proapoptotic	ADJ
admet-2874	227	13	effect	effect	NOUN
admet-2874	227	14	[	[	X
admet-2874	227	15	151	151	NUM
admet-2874	227	16	]	]	SYM
admet-2874	227	17	asialoglycoprotein	asialoglycoprotein	ADJ
admet-2874	227	18	receptor	receptor	NOUN
admet-2874	227	19	+	+	CCONJ
admet-2874	227	20	ga	ga	NOUN
admet-2874	227	21	receptor	receptor	NOUN
admet-2874	227	22	galactosepeg2000	galactosepeg2000	PROPN
admet-2874	227	23	-	-	PUNCT
admet-2874	227	24	nh₂	nh₂	NOUN
admet-2874	227	25	(	(	PUNCT
admet-2874	227	26	galnh₂	galnh₂	NOUN
admet-2874	227	27	)	)	PUNCT
admet-2874	228	1	+	+	CCONJ
admet-2874	228	2	glycyrrhetinic	glycyrrhetinic	ADJ
admet-2874	228	3	acid	acid	NOUN
admet-2874	228	4	nanostructured	nanostructure	VERB
admet-2874	228	5	lipid	lipid	NOUN
admet-2874	228	6	carriers	carrier	NOUN
admet-2874	228	7	dehydrocavidine	dehydrocavidine	PROPN
admet-2874	228	8	↑	↑	PROPN
admet-2874	228	9	liver	liver	PROPN
admet-2874	228	10	targeting	targeting	NOUN
admet-2874	228	11	,	,	PUNCT
admet-2874	228	12	↑	↑	NOUN
admet-2874	228	13	uptake	uptake	ADJ
admet-2874	228	14	by	by	ADP
admet-2874	228	15	ahscs	ahsc	NOUN
admet-2874	228	16	,	,	PUNCT
admet-2874	228	17	apoptosis	apoptosis	NOUN
admet-2874	228	18	induction	induction	NOUN
admet-2874	228	19	↓fibrosis	↓fibrosis	NUM
admet-2874	228	20	markers	marker	NOUN
admet-2874	228	21	[	[	X
admet-2874	228	22	152	152	NUM
admet-2874	228	23	]	]	PUNCT
admet-2874	228	24	cation	cation	NOUN
admet-2874	228	25	-	-	PUNCT
admet-2874	228	26	independent	independent	ADJ
admet-2874	228	27	mannose-6phosphate	mannose-6phosphate	ADJ
admet-2874	228	28	receptor	receptor	NOUN
admet-2874	228	29	(	(	PUNCT
admet-2874	228	30	ci	ci	NOUN
admet-2874	228	31	-	-	PUNCT
admet-2874	228	32	m6pr	m6pr	NOUN
admet-2874	228	33	)	)	PUNCT
admet-2874	228	34	ligands	ligand	NOUN
admet-2874	228	35	targeting	target	VERB
admet-2874	228	36	tgf	tgf	PROPN
admet-2874	228	37	-	-	PUNCT
admet-2874	228	38	β	β	NOUN
admet-2874	228	39	receptor	receptor	NOUN
admet-2874	228	40	i	i	PRON
admet-2874	228	41	and	and	CCONJ
admet-2874	228	42	ci	ci	NOUN
admet-2874	228	43	-	-	ADJ
admet-2874	228	44	m6pr	m6pr	NOUN
admet-2874	228	45	polydopamine	polydopamine	NOUN
admet-2874	228	46	(	(	PUNCT
admet-2874	228	47	pda	pda	NOUN
admet-2874	228	48	)	)	PUNCT
admet-2874	228	49	nanoparticles	nanoparticle	NOUN
admet-2874	228	50	ligand	ligand	VERB
admet-2874	228	51	targeting	target	VERB
admet-2874	228	52	tgf	tgf	PROPN
admet-2874	228	53	-	-	PUNCT
admet-2874	228	54	β	β	NOUN
admet-2874	228	55	receptor	receptor	NOUN
admet-2874	228	56	i	i	PRON
admet-2874	228	57	↑accumulation	↑accumulation	VERB
admet-2874	228	58	in	in	ADP
admet-2874	228	59	fibrotic	fibrotic	ADJ
admet-2874	228	60	liver	liver	NOUN
admet-2874	228	61	tissue	tissue	NOUN
admet-2874	228	62	↓	↓	NOUN
admet-2874	228	63	ros	ros	PROPN
admet-2874	228	64	↓transforming	↓transforme	VERB
admet-2874	228	65	growth	growth	NOUN
admet-2874	228	66	factor	factor	NOUN
admet-2874	228	67	-	-	PUNCT
admet-2874	228	68	beta	beta	NOUN
admet-2874	228	69	(	(	PUNCT
admet-2874	228	70	tgf	tgf	PROPN
admet-2874	228	71	-	-	PUNCT
admet-2874	228	72	β	β	NOUN
admet-2874	228	73	)	)	PUNCT
admet-2874	228	74	production	production	NOUN
admet-2874	228	75	targeted	target	VERB
admet-2874	228	76	lysosomal	lysosomal	ADJ
admet-2874	228	77	degradation	degradation	NOUN
admet-2874	228	78	of	of	ADP
admet-2874	228	79	tgf	tgf	PROPN
admet-2874	228	80	-	-	PUNCT
admet-2874	228	81	β	β	NOUN
admet-2874	228	82	inhibition	inhibition	NOUN
admet-2874	228	83	of	of	ADP
admet-2874	228	84	tgf	tgf	PROPN
admet-2874	228	85	-	-	PUNCT
admet-2874	228	86	β	β	NOUN
admet-2874	228	87	-	-	NOUN
admet-2874	228	88	smad2/3	smad2/3	NOUN
admet-2874	228	89	signaling	signal	VERB
admet-2874	228	90	pathway	pathway	NOUN
admet-2874	228	91	[	[	X
admet-2874	228	92	153	153	NUM
admet-2874	228	93	]	]	X
admet-2874	228	94	admet	admet	PROPN
admet-2874	228	95	&	&	CCONJ
admet-2874	228	96	dmpk	dmpk	PROPN
admet-2874	228	97	13(4	13(4	NUM
admet-2874	228	98	)	)	PUNCT
admet-2874	228	99	(	(	PUNCT
admet-2874	228	100	2025	2025	NUM
admet-2874	228	101	)	)	PUNCT
admet-2874	228	102	2874	2874	NUM
admet-2874	228	103	hscs	hsc	NOUN
admet-2874	228	104	in	in	ADP
admet-2874	228	105	liver	liver	NOUN
admet-2874	228	106	fibrosis	fibrosis	NOUN
admet-2874	228	107	:	:	PUNCT
admet-2874	228	108	therapeutic	therapeutic	ADJ
admet-2874	228	109	advances	advance	NOUN
admet-2874	228	110	doi	doi	NOUN
admet-2874	228	111	:	:	PUNCT
admet-2874	228	112	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	228	113	13	13	NUM
admet-2874	228	114	molecular	molecular	ADJ
admet-2874	228	115	targets	target	NOUN
admet-2874	228	116	/	/	SYM
admet-2874	228	117	receptors	receptor	NOUN
admet-2874	228	118	targeting	target	VERB
admet-2874	228	119	ligand	ligand	ADJ
admet-2874	228	120	carrier	carrier	NOUN
admet-2874	228	121	drug	drug	NOUN
admet-2874	228	122	outcomes	outcome	NOUN
admet-2874	228	123	ref	ref	VERB
admet-2874	228	124	.	.	PUNCT
admet-2874	229	1	↓ecm	↓ecm	VERB
admet-2874	229	2	secretion	secretion	VERB
admet-2874	229	3	significant	significant	ADJ
admet-2874	229	4	attenuation	attenuation	NOUN
admet-2874	229	5	of	of	ADP
admet-2874	229	6	liver	liver	NOUN
admet-2874	229	7	fibrosis	fibrosis	NOUN
admet-2874	229	8	collagen	collagen	NOUN
admet-2874	230	1	i	i	PRON
admet-2874	230	2	(	(	PUNCT
admet-2874	230	3	ecm	ecm	PROPN
admet-2874	230	4	component	component	NOUN
admet-2874	230	5	)	)	PUNCT
admet-2874	230	6	succinylated	succinylate	VERB
admet-2874	230	7	gelatin	gelatin	NOUN
admet-2874	230	8	succinylated	succinylate	VERB
admet-2874	230	9	gelatin	gelatin	NOUN
admet-2874	230	10	-coated	-coate	VERB
admet-2874	230	11	liposomes	liposome	NOUN
admet-2874	230	12	(	(	PUNCT
admet-2874	230	13	sg	sg	NOUN
admet-2874	230	14	-	-	PUNCT
admet-2874	230	15	lip	lip	NOUN
admet-2874	230	16	)	)	PUNCT
admet-2874	230	17	pirfenidone	pirfenidone	NOUN
admet-2874	230	18	prolonged	prolong	VERB
admet-2874	230	19	retention	retention	NOUN
admet-2874	230	20	,	,	PUNCT
admet-2874	230	21	enzymeresponsive	enzymeresponsive	ADJ
admet-2874	230	22	release	release	NOUN
admet-2874	230	23	,	,	PUNCT
admet-2874	230	24	↓	↓	NOUN
admet-2874	230	25	fibroblast	fibroblast	ADJ
admet-2874	230	26	proliferation	proliferation	NOUN
admet-2874	230	27	,	,	PUNCT
admet-2874	230	28	invasion	invasion	NOUN
admet-2874	230	29	,	,	PUNCT
admet-2874	230	30	and	and	CCONJ
admet-2874	230	31	myofibroblast	myofibroblast	NOUN
admet-2874	230	32	differentiation	differentiation	NOUN
admet-2874	230	33	[	[	X
admet-2874	230	34	154	154	NUM
admet-2874	230	35	]	]	PUNCT
admet-2874	230	36	cd44	cd44	PROPN
admet-2874	230	37	chondroitin	chondroitin	NOUN
admet-2874	230	38	sulfate	sulfate	NOUN
admet-2874	230	39	-	-	PUNCT
admet-2874	230	40	hexadecylamine	hexadecylamine	NOUN
admet-2874	230	41	conjugate	conjugate	NOUN
admet-2874	230	42	(	(	PUNCT
admet-2874	230	43	cs	cs	ADJ
admet-2874	230	44	-	-	ADJ
admet-2874	230	45	hda	hda	ADJ
admet-2874	230	46	)	)	PUNCT
admet-2874	230	47	amphiphilic	amphiphilic	ADJ
admet-2874	230	48	cshda	cshda	NOUN
admet-2874	230	49	-	-	PUNCT
admet-2874	230	50	based	base	VERB
admet-2874	230	51	nanoparticles	nanoparticle	NOUN
admet-2874	230	52	imatinib	imatinib	NOUN
admet-2874	230	53	↑	↑	NOUN
admet-2874	230	54	uptake	uptake	ADJ
admet-2874	230	55	by	by	ADP
admet-2874	230	56	ahscs	ahsc	NOUN
admet-2874	230	57	;	;	PUNCT
admet-2874	230	58	fibrosis	fibrosis	NOUN
admet-2874	230	59	resolution	resolution	NOUN
admet-2874	230	60	in	in	ADP
admet-2874	230	61	mouse	mouse	NOUN
admet-2874	230	62	model	model	NOUN
admet-2874	230	63	[	[	X
admet-2874	230	64	155	155	NUM
admet-2874	230	65	]	]	PUNCT
admet-2874	230	66	asialoglycoprotein	asialoglycoprotein	ADJ
admet-2874	230	67	receptor	receptor	NOUN
admet-2874	230	68	dspe	dspe	PROPN
admet-2874	230	69	-	-	PUNCT
admet-2874	230	70	peggalactose	peggalactose	NOUN
admet-2874	230	71	self	self	NOUN
admet-2874	230	72	-	-	PUNCT
admet-2874	230	73	assembled	assemble	VERB
admet-2874	230	74	shg	shg	NOUN
admet-2874	230	75	nanoparticles	nanoparticle	NOUN
admet-2874	230	76	sorafenib	sorafenib	NOUN
admet-2874	230	77	and	and	CCONJ
admet-2874	230	78	hederagenin	hederagenin	ADJ
admet-2874	230	79	derivative	derivative	NOUN
admet-2874	230	80	(	(	PUNCT
admet-2874	230	81	he	he	PRON
admet-2874	230	82	d	d	PROPN
admet-2874	230	83	)	)	PUNCT
admet-2874	230	84	↓	↓	NOUN
admet-2874	230	85	collagen	collagen	NOUN
admet-2874	230	86	deposition	deposition	NOUN
admet-2874	230	87	by	by	ADP
admet-2874	230	88	57.5	57.5	NUM
admet-2874	230	89	±	±	NUM
admet-2874	230	90	2.3	2.3	NUM
admet-2874	230	91	%	%	NOUN
admet-2874	230	92	(	(	PUNCT
admet-2874	230	93	vs.	vs.	ADP
admet-2874	230	94	24.8	24.8	NUM
admet-2874	230	95	±	±	NUM
admet-2874	230	96	1.8	1.8	NUM
admet-2874	230	97	%	%	NOUN
admet-2874	230	98	with	with	ADP
admet-2874	230	99	sorafenib	sorafenib	NOUN
admet-2874	230	100	alone	alone	ADV
admet-2874	230	101	)	)	PUNCT
admet-2874	230	102	;	;	PUNCT
admet-2874	230	103	↑	↑	NOUN
admet-2874	230	104	uptake	uptake	ADJ
admet-2874	230	105	in	in	ADP
admet-2874	230	106	asgpr	asgpr	ADV
admet-2874	230	107	-	-	PUNCT
admet-2874	230	108	overexpressing	overexpresse	VERB
admet-2874	230	109	hscs	hsc	NOUN
admet-2874	230	110	;	;	PUNCT
admet-2874	230	111	↑	↑	NUM
admet-2874	230	112	anti	anti	ADJ
admet-2874	230	113	-	-	ADJ
admet-2874	230	114	fibrotic	fibrotic	ADJ
admet-2874	230	115	efficacy	efficacy	NOUN
admet-2874	230	116	(	(	PUNCT
admet-2874	230	117	in	in	ADP
admet-2874	230	118	vivo	vivo	NOUN
admet-2874	230	119	)	)	PUNCT
admet-2874	231	1	[	[	X
admet-2874	231	2	156	156	NUM
admet-2874	231	3	]	]	PUNCT
admet-2874	231	4	retinol	retinol	NOUN
admet-2874	231	5	-	-	PUNCT
admet-2874	231	6	binding	bind	VERB
admet-2874	231	7	protein	protein	NOUN
admet-2874	231	8	receptor	receptor	NOUN
admet-2874	231	9	(	(	PUNCT
admet-2874	231	10	rbpr	rbpr	NOUN
admet-2874	231	11	)	)	PUNCT
admet-2874	231	12	vitamin	vitamin	NOUN
admet-2874	231	13	a	a	DET
admet-2874	231	14	(	(	PUNCT
admet-2874	231	15	va	va	NOUN
admet-2874	231	16	)	)	PUNCT
admet-2874	231	17	vitamin	vitamin	NOUN
admet-2874	231	18	a	a	DET
admet-2874	231	19	-	-	PUNCT
admet-2874	231	20	pegpntc(poly(ethylene	pegpntc(poly(ethylene	ADJ
admet-2874	231	21	glycol)-poly(nitrate	glycol)-poly(nitrate	NOUN
admet-2874	231	22	carbonate	carbonate	NOUN
admet-2874	231	23	)	)	PUNCT
admet-2874	231	24	micelle	micelle	NOUN
admet-2874	231	25	benazepril	benazepril	VERB
admet-2874	231	26	(	(	PUNCT
admet-2874	231	27	bn	bn	NOUN
admet-2874	231	28	)	)	PUNCT
admet-2874	231	29	targeted	target	VERB
admet-2874	231	30	delivery	delivery	NOUN
admet-2874	231	31	to	to	ADP
admet-2874	231	32	activated	activate	VERB
admet-2874	231	33	hscs	hsc	NOUN
admet-2874	231	34	;	;	PUNCT
admet-2874	231	35	controlled	control	VERB
admet-2874	231	36	no	no	DET
admet-2874	231	37	release	release	NOUN
admet-2874	231	38	led	lead	VERB
admet-2874	231	39	to	to	ADP
admet-2874	231	40	↓	↓	PROPN
admet-2874	231	41	α	α	PROPN
admet-2874	231	42	-	-	PUNCT
admet-2874	231	43	sma	sma	NOUN
admet-2874	231	44	,	,	PUNCT
admet-2874	231	45	induction	induction	NOUN
admet-2874	231	46	of	of	ADP
admet-2874	231	47	apoptosis	apoptosis	NOUN
admet-2874	231	48	,	,	PUNCT
admet-2874	231	49	and	and	CCONJ
admet-2874	231	50	↓	↓	PROPN
admet-2874	231	51	fibrosis	fibrosis	NOUN
admet-2874	231	52	[	[	X
admet-2874	231	53	157	157	NUM
admet-2874	231	54	]	]	X
admet-2874	231	55	tgf	tgf	PROPN
admet-2874	231	56	-	-	PUNCT
admet-2874	231	57	β1	β1	PROPN
admet-2874	231	58	galactose	galactose	NOUN
admet-2874	231	59	bilosomes	bilosome	NOUN
admet-2874	231	60	sofosbuvir	sofosbuvir	PROPN
admet-2874	231	61	drug	drug	PROPN
admet-2874	231	62	loaded	load	VERB
admet-2874	231	63	bilosomes	bilosome	NOUN
admet-2874	231	64	improved	improve	VERB
admet-2874	231	65	liver	liver	NOUN
admet-2874	231	66	function	function	NOUN
admet-2874	231	67	(	(	PUNCT
admet-2874	231	68	↓	↓	PROPN
admet-2874	231	69	ast	ast	PROPN
admet-2874	231	70	,	,	PUNCT
admet-2874	231	71	alt	alt	ADJ
admet-2874	231	72	,	,	PUNCT
admet-2874	231	73	alp	alp	PROPN
admet-2874	231	74	)	)	PUNCT
admet-2874	231	75	,	,	PUNCT
admet-2874	231	76	↓	↓	PROPN
admet-2874	231	77	tgf	tgf	PROPN
admet-2874	231	78	-	-	PUNCT
admet-2874	231	79	β1	β1	PROPN
admet-2874	231	80	levels	level	NOUN
admet-2874	231	81	,	,	PUNCT
admet-2874	231	82	and	and	CCONJ
admet-2874	231	83	regressed	regress	VERB
admet-2874	231	84	liver	liver	NOUN
admet-2874	231	85	fibrosis	fibrosis	NOUN
admet-2874	231	86	score	score	NOUN
admet-2874	231	87	in	in	ADP
admet-2874	231	88	animal	animal	NOUN
admet-2874	231	89	model	model	NOUN
admet-2874	232	1	[	[	X
admet-2874	232	2	158	158	NUM
admet-2874	232	3	]	]	X
admet-2874	232	4	α	α	PROPN
admet-2874	232	5	-	-	PUNCT
admet-2874	232	6	sma	sma	PROPN
admet-2874	232	7	,	,	PUNCT
admet-2874	232	8	col1a1	col1a1	NOUN
admet-2874	232	9	igfbp-3targeting	igfbp-3targete	VERB
admet-2874	232	10	moiety	moiety	NOUN
admet-2874	232	11	xanthosomes	xanthosome	NOUN
admet-2874	232	12	tmem219	tmem219	PROPN
admet-2874	232	13	(	(	PUNCT
admet-2874	232	14	transmembrane	transmembrane	ADJ
admet-2874	232	15	protein	protein	NOUN
admet-2874	232	16	219	219	NUM
admet-2874	232	17	)	)	PUNCT
admet-2874	232	18	↓	↓	NOUN
admet-2874	232	19	α	α	X
admet-2874	232	20	-	-	PUNCT
admet-2874	232	21	sma	sma	PROPN
admet-2874	232	22	,	,	PUNCT
admet-2874	232	23	↓	↓	PROPN
admet-2874	232	24	col1a1	col1a1	PROPN
admet-2874	232	25	,	,	PUNCT
admet-2874	232	26	↓	↓	PROPN
admet-2874	232	27	igfbp-3	igfbp-3	NUM
admet-2874	232	28	,	,	PUNCT
admet-2874	232	29	↓	↓	PROPN
admet-2874	232	30	tgf	tgf	PROPN
admet-2874	232	31	-	-	PUNCT
admet-2874	232	32	β1	β1	PROPN
admet-2874	232	33	,	,	PUNCT
admet-2874	232	34	↓	↓	PROPN
admet-2874	232	35	p	p	PROPN
admet-2874	232	36	-	-	PUNCT
admet-2874	232	37	akt	akt	PROPN
admet-2874	232	38	;	;	PUNCT
admet-2874	232	39	↓alt	↓alt	NUM
admet-2874	232	40	,	,	PUNCT
admet-2874	232	41	ast	ast	PROPN
admet-2874	232	42	)	)	PUNCT
admet-2874	232	43	;	;	PUNCT
admet-2874	232	44	↓	↓	NOUN
admet-2874	232	45	necrosis	necrosis	NOUN
admet-2874	232	46	,	,	PUNCT
admet-2874	232	47	inflammation	inflammation	NOUN
admet-2874	232	48	,	,	PUNCT
admet-2874	232	49	and	and	CCONJ
admet-2874	232	50	fibrogenesis	fibrogenesis	VERB
admet-2874	232	51	in	in	ADP
admet-2874	232	52	bdl	bdl	PROPN
admet-2874	232	53	-	-	PUNCT
admet-2874	232	54	induced	induce	VERB
admet-2874	232	55	fibrosis	fibrosis	NOUN
admet-2874	232	56	[	[	X
admet-2874	232	57	159	159	NUM
admet-2874	232	58	]	]	X
admet-2874	232	59	fap	fap	NOUN
admet-2874	232	60	-	-	PUNCT
admet-2874	232	61	α	α	PRON
admet-2874	232	62	hepatic	hepatic	ADJ
admet-2874	232	63	fibrosistargeting	fibrosistargeting	NOUN
admet-2874	232	64	peptide	peptide	NOUN
admet-2874	232	65	(	(	PUNCT
admet-2874	232	66	fap	fap	NOUN
admet-2874	232	67	-	-	PUNCT
admet-2874	232	68	αresponsive	αresponsive	ADJ
admet-2874	232	69	)	)	PUNCT
admet-2874	232	70	fap	fap	NOUN
admet-2874	232	71	-	-	PUNCT
admet-2874	232	72	αnano	αnano	NOUN
admet-2874	232	73	shells	shell	NOUN
admet-2874	232	74	(	(	PUNCT
admet-2874	232	75	pfd@ns	pfd@ns	NOUN
admet-2874	232	76	)	)	PUNCT
admet-2874	232	77	pirfenidone	pirfenidone	NOUN
admet-2874	232	78	(	(	PUNCT
admet-2874	232	79	pfd	pfd	PROPN
admet-2874	232	80	)	)	PUNCT
admet-2874	232	81	targeted	target	VERB
admet-2874	232	82	delivery	delivery	NOUN
admet-2874	232	83	to	to	ADP
admet-2874	232	84	fibrotic	fibrotic	ADJ
admet-2874	232	85	liver	liver	NOUN
admet-2874	232	86	,	,	PUNCT
admet-2874	232	87	↓	↓	PROPN
admet-2874	232	88	tgf	tgf	PROPN
admet-2874	232	89	-	-	PUNCT
admet-2874	232	90	β1	β1	NOUN
admet-2874	232	91	-	-	PUNCT
admet-2874	232	92	induced	induce	VERB
admet-2874	232	93	collagen	collagen	NOUN
admet-2874	232	94	production	production	NOUN
admet-2874	232	95	,	,	PUNCT
admet-2874	232	96	↓	↓	PROPN
admet-2874	232	97	hsc	hsc	PROPN
admet-2874	232	98	activation	activation	NOUN
admet-2874	232	99	,	,	PUNCT
admet-2874	232	100	↓	↓	PROPN
admet-2874	232	101	inflammation	inflammation	NOUN
admet-2874	232	102	,	,	PUNCT
admet-2874	232	103	modulation	modulation	NOUN
admet-2874	232	104	of	of	ADP
admet-2874	232	105	pi3k	pi3k	PROPN
admet-2874	232	106	/	/	SYM
admet-2874	232	107	akt	akt	PROPN
admet-2874	232	108	/	/	SYM
admet-2874	232	109	mtor	mtor	PROPN
admet-2874	232	110	pathway	pathway	NOUN
admet-2874	232	111	,	,	PUNCT
admet-2874	232	112	↑	↑	PROPN
admet-2874	232	113	antifibrotic	antifibrotic	ADJ
admet-2874	232	114	efficacy	efficacy	NOUN
admet-2874	232	115	,	,	PUNCT
admet-2874	232	116	↓	↓	PROPN
admet-2874	232	117	off	off	ADP
admet-2874	232	118	-	-	PUNCT
admet-2874	232	119	target	target	NOUN
admet-2874	232	120	effects	effect	NOUN
admet-2874	232	121	[	[	X
admet-2874	232	122	160	160	NUM
admet-2874	232	123	]	]	X
admet-2874	232	124	retinoid	retinoid	NOUN
admet-2874	232	125	receptors	receptor	NOUN
admet-2874	232	126	retinoid	retinoid	NOUN
admet-2874	232	127	(	(	PUNCT
admet-2874	232	128	vitamin	vitamin	NOUN
admet-2874	232	129	a	a	PRON
admet-2874	232	130	)	)	PUNCT
admet-2874	232	131	retinoid	retinoid	PROPN
admet-2874	232	132	decorated	decorate	VERB
admet-2874	232	133	rbc	rbc	PROPN
admet-2874	232	134	membrane	membrane	NOUN
admet-2874	232	135	encapsulated	encapsulate	VERB
admet-2874	232	136	polydopamine	polydopamine	NOUN
admet-2874	232	137	nanoparticles	nanoparticle	NOUN
admet-2874	232	138	sorafenib	sorafenib	PROPN
admet-2874	232	139	↑	↑	PROPN
admet-2874	232	140	ahsc	ahsc	PROPN
admet-2874	232	141	targeting	target	VERB
admet-2874	232	142	,	,	PUNCT
admet-2874	232	143	↓	↓	PROPN
admet-2874	232	144	hif-1α	hif-1α	PROPN
admet-2874	232	145	&	&	CCONJ
admet-2874	232	146	glycolysis	glycolysis	NOUN
admet-2874	232	147	,	,	PUNCT
admet-2874	232	148	reversal	reversal	NOUN
admet-2874	232	149	of	of	ADP
admet-2874	232	150	myofibroblast	myofibroblast	NOUN
admet-2874	232	151	phenotype	phenotype	NOUN
admet-2874	232	152	,	,	PUNCT
admet-2874	232	153	↓	↓	NOUN
admet-2874	232	154	liver	liver	NOUN
admet-2874	232	155	inflammation	inflammation	NOUN
admet-2874	232	156	and	and	CCONJ
admet-2874	232	157	fibrosis	fibrosis	NOUN
admet-2874	232	158	in	in	ADP
admet-2874	232	159	ccl₄-induced	ccl₄-induced	ADJ
admet-2874	232	160	mice	mouse	NOUN
admet-2874	233	1	[	[	X
admet-2874	233	2	161	161	NUM
admet-2874	233	3	]	]	X
admet-2874	233	4	ha	ha	INTJ
admet-2874	233	5	receptor	receptor	NOUN
admet-2874	233	6	(	(	PUNCT
admet-2874	233	7	e.g.	e.g.	ADV
admet-2874	233	8	cd44	cd44	PROPN
admet-2874	233	9	on	on	ADP
admet-2874	233	10	activated	activate	VERB
admet-2874	233	11	hscs	hsc	NOUN
admet-2874	233	12	)	)	PUNCT
admet-2874	233	13	hyaluronic	hyaluronic	ADJ
admet-2874	233	14	acid	acid	NOUN
admet-2874	233	15	(	(	PUNCT
admet-2874	233	16	ha	ha	INTJ
admet-2874	233	17	)	)	PUNCT
admet-2874	233	18	cu²⁺-coordinated	cu²⁺-coordinate	VERB
admet-2874	233	19	mesoporous	mesoporous	ADJ
admet-2874	233	20	curcumin	curcumin	NOUN
admet-2874	233	21	effective	effective	ADJ
admet-2874	233	22	liver	liver	NOUN
admet-2874	233	23	targeting	targeting	NOUN
admet-2874	233	24	,	,	PUNCT
admet-2874	233	25	ros	ros	PROPN
admet-2874	233	26	scavenging	scavenging	NOUN
admet-2874	233	27	,	,	PUNCT
admet-2874	233	28	↓	↓	PROPN
admet-2874	233	29	hsc	hsc	PROPN
admet-2874	233	30	proliferation	proliferation	NOUN
admet-2874	233	31	,	,	PUNCT
admet-2874	233	32	collagen	collagen	NOUN
admet-2874	233	33	deposition	deposition	NOUN
admet-2874	233	34	,	,	PUNCT
admet-2874	233	35	↑	↑	NOUN
admet-2874	233	36	antioxidant	antioxidant	ADJ
admet-2874	233	37	activity	activity	NOUN
admet-2874	233	38	,	,	PUNCT
admet-2874	233	39	phresponsive	phresponsive	ADJ
admet-2874	233	40	drug	drug	NOUN
admet-2874	233	41	release	release	NOUN
admet-2874	233	42	,	,	PUNCT
admet-2874	233	43	and	and	CCONJ
admet-2874	233	44	alleviation	alleviation	NOUN
admet-2874	233	45	of	of	ADP
admet-2874	233	46	liver	liver	NOUN
admet-2874	233	47	fibrosis	fibrosis	NOUN
admet-2874	233	48	[	[	X
admet-2874	233	49	162	162	NUM
admet-2874	233	50	]	]	PUNCT
admet-2874	233	51	conclusion	conclusion	NOUN
admet-2874	233	52	liver	liver	NOUN
admet-2874	233	53	fibrosis	fibrosis	NOUN
admet-2874	233	54	has	have	AUX
admet-2874	233	55	emerged	emerge	VERB
admet-2874	233	56	as	as	ADP
admet-2874	233	57	a	a	DET
admet-2874	233	58	major	major	ADJ
admet-2874	233	59	pathological	pathological	ADJ
admet-2874	233	60	outcome	outcome	NOUN
admet-2874	233	61	of	of	ADP
admet-2874	233	62	various	various	ADJ
admet-2874	233	63	liver	liver	NOUN
admet-2874	233	64	disorders	disorder	NOUN
admet-2874	233	65	,	,	PUNCT
admet-2874	233	66	often	often	ADV
admet-2874	233	67	progressing	progress	VERB
admet-2874	233	68	to	to	ADP
admet-2874	233	69	hepatocellular	hepatocellular	ADJ
admet-2874	233	70	carcinoma	carcinoma	NOUN
admet-2874	233	71	and	and	CCONJ
admet-2874	233	72	contributing	contribute	VERB
admet-2874	233	73	significantly	significantly	ADV
admet-2874	233	74	to	to	ADP
admet-2874	233	75	increased	increase	VERB
admet-2874	233	76	mortality	mortality	NOUN
admet-2874	233	77	,	,	PUNCT
admet-2874	233	78	morbidity	morbidity	NOUN
admet-2874	233	79	,	,	PUNCT
admet-2874	233	80	and	and	CCONJ
admet-2874	233	81	economic	economic	ADJ
admet-2874	233	82	burden	burden	NOUN
admet-2874	233	83	.	.	PUNCT
admet-2874	234	1	although	although	SCONJ
admet-2874	234	2	numerous	numerous	ADJ
admet-2874	234	3	clinical	clinical	ADJ
admet-2874	234	4	trials	trial	NOUN
admet-2874	234	5	have	have	AUX
admet-2874	234	6	been	be	AUX
admet-2874	234	7	conducted	conduct	VERB
admet-2874	234	8	to	to	PART
admet-2874	234	9	address	address	VERB
admet-2874	234	10	liver	liver	NOUN
admet-2874	234	11	fibrosis	fibrosis	NOUN
admet-2874	234	12	associated	associate	VERB
admet-2874	234	13	with	with	ADP
admet-2874	234	14	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	234	15	a.	a.	NOUN
admet-2874	234	16	singh	singh	PROPN
admet-2874	234	17	et	et	PROPN
admet-2874	234	18	al	al	PROPN
admet-2874	234	19	.	.	PROPN
admet-2874	234	20	admet	admet	PROPN
admet-2874	234	21	&	&	CCONJ
admet-2874	234	22	dmpk	dmpk	PROPN
admet-2874	234	23	13(4	13(4	NUM
admet-2874	234	24	)	)	PUNCT
admet-2874	234	25	(	(	PUNCT
admet-2874	234	26	2025	2025	NUM
admet-2874	234	27	)	)	PUNCT
admet-2874	234	28	2874	2874	NUM
admet-2874	234	29	14	14	NUM
admet-2874	234	30	diverse	diverse	ADJ
admet-2874	234	31	etiologies	etiology	NOUN
admet-2874	234	32	,	,	PUNCT
admet-2874	234	33	the	the	DET
admet-2874	234	34	majority	majority	NOUN
admet-2874	234	35	were	be	AUX
admet-2874	234	36	discontinued	discontinue	VERB
admet-2874	234	37	during	during	ADP
admet-2874	234	38	phase	phase	NOUN
admet-2874	234	39	2	2	NUM
admet-2874	234	40	or	or	CCONJ
admet-2874	234	41	3	3	NUM
admet-2874	234	42	due	due	ADP
admet-2874	234	43	to	to	ADP
admet-2874	234	44	a	a	DET
admet-2874	234	45	lack	lack	NOUN
admet-2874	234	46	of	of	ADP
admet-2874	234	47	therapeutic	therapeutic	ADJ
admet-2874	234	48	efficacy	efficacy	NOUN
admet-2874	234	49	(	(	PUNCT
admet-2874	234	50	e.g.	e.g.	ADV
admet-2874	234	51	simtuzumab	simtuzumab	NOUN
admet-2874	234	52	)	)	PUNCT
admet-2874	234	53	.	.	PUNCT
admet-2874	235	1	only	only	ADV
admet-2874	235	2	a	a	DET
admet-2874	235	3	few	few	ADJ
admet-2874	235	4	drugs	drug	NOUN
admet-2874	235	5	,	,	PUNCT
admet-2874	235	6	such	such	ADJ
admet-2874	235	7	as	as	ADP
admet-2874	235	8	adafermin	adafermin	NOUN
admet-2874	235	9	and	and	CCONJ
admet-2874	235	10	aramchol	aramchol	NOUN
admet-2874	235	11	,	,	PUNCT
admet-2874	235	12	have	have	AUX
admet-2874	235	13	shown	show	VERB
admet-2874	235	14	promising	promising	ADJ
admet-2874	235	15	results	result	NOUN
admet-2874	235	16	in	in	ADP
admet-2874	235	17	phase	phase	NOUN
admet-2874	235	18	2	2	NUM
admet-2874	235	19	and	and	CCONJ
admet-2874	235	20	3	3	NUM
admet-2874	235	21	trials	trial	NOUN
admet-2874	235	22	.	.	PUNCT
admet-2874	236	1	notably	notably	ADV
admet-2874	236	2	,	,	PUNCT
admet-2874	236	3	setanaxib	setanaxib	NOUN
admet-2874	236	4	is	be	AUX
admet-2874	236	5	currently	currently	ADV
admet-2874	236	6	the	the	DET
admet-2874	236	7	only	only	ADJ
admet-2874	236	8	molecule	molecule	NOUN
admet-2874	236	9	approved	approve	VERB
admet-2874	236	10	by	by	ADP
admet-2874	236	11	the	the	DET
admet-2874	236	12	u.s	u.s	PROPN
admet-2874	236	13	.	.	PROPN
admet-2874	236	14	fda	fda	PROPN
admet-2874	236	15	for	for	ADP
admet-2874	236	16	the	the	DET
admet-2874	236	17	treatment	treatment	NOUN
admet-2874	236	18	of	of	ADP
admet-2874	236	19	liver	liver	NOUN
admet-2874	236	20	fibrosis	fibrosis	NOUN
admet-2874	236	21	.	.	PUNCT
admet-2874	237	1	in	in	ADP
admet-2874	237	2	recent	recent	ADJ
admet-2874	237	3	years	year	NOUN
admet-2874	237	4	,	,	PUNCT
admet-2874	237	5	hepatic	hepatic	ADJ
admet-2874	237	6	stellate	stellate	ADJ
admet-2874	237	7	cells	cell	NOUN
admet-2874	237	8	(	(	PUNCT
admet-2874	237	9	hscs	hsc	NOUN
admet-2874	237	10	)	)	PUNCT
admet-2874	237	11	have	have	AUX
admet-2874	237	12	emerged	emerge	VERB
admet-2874	237	13	as	as	ADP
admet-2874	237	14	key	key	ADJ
admet-2874	237	15	mediators	mediator	NOUN
admet-2874	237	16	and	and	CCONJ
admet-2874	237	17	therapeutic	therapeutic	ADJ
admet-2874	237	18	targets	target	NOUN
admet-2874	237	19	in	in	ADP
admet-2874	237	20	liver	liver	NOUN
admet-2874	237	21	fibrosis	fibrosis	NOUN
admet-2874	237	22	.	.	PUNCT
admet-2874	238	1	pharmacological	pharmacological	ADJ
admet-2874	238	2	interventions	intervention	NOUN
admet-2874	238	3	targeting	target	VERB
admet-2874	238	4	liver	liver	NOUN
admet-2874	238	5	fibrosis	fibrosis	NOUN
admet-2874	238	6	have	have	AUX
admet-2874	238	7	demonstrated	demonstrate	VERB
admet-2874	238	8	encouraging	encouraging	ADJ
admet-2874	238	9	results	result	NOUN
admet-2874	238	10	in	in	ADP
admet-2874	238	11	experimental	experimental	ADJ
admet-2874	238	12	models	model	NOUN
admet-2874	238	13	;	;	PUNCT
admet-2874	238	14	however	however	ADV
admet-2874	238	15	,	,	PUNCT
admet-2874	238	16	clinical	clinical	ADJ
admet-2874	238	17	trials	trial	NOUN
admet-2874	238	18	remain	remain	VERB
admet-2874	238	19	limited	limited	ADJ
admet-2874	238	20	.	.	PUNCT
admet-2874	239	1	among	among	ADP
admet-2874	239	2	these	these	DET
admet-2874	239	3	approaches	approach	NOUN
admet-2874	239	4	,	,	PUNCT
admet-2874	239	5	the	the	DET
admet-2874	239	6	active	active	ADJ
admet-2874	239	7	targeting	targeting	NOUN
admet-2874	239	8	of	of	ADP
admet-2874	239	9	hscs	hsc	NOUN
admet-2874	239	10	has	have	AUX
admet-2874	239	11	shown	show	VERB
admet-2874	239	12	significant	significant	ADJ
admet-2874	239	13	promise	promise	NOUN
admet-2874	239	14	in	in	ADP
admet-2874	239	15	preclinical	preclinical	ADJ
admet-2874	239	16	studies	study	NOUN
admet-2874	239	17	for	for	ADP
admet-2874	239	18	the	the	DET
admet-2874	239	19	resolution	resolution	NOUN
admet-2874	239	20	of	of	ADP
admet-2874	239	21	liver	liver	NOUN
admet-2874	239	22	fibrosis	fibrosis	NOUN
admet-2874	239	23	.	.	PUNCT
admet-2874	240	1	combining	combine	VERB
admet-2874	240	2	active	active	ADJ
admet-2874	240	3	targeting	targeting	NOUN
admet-2874	240	4	strategies	strategy	NOUN
admet-2874	240	5	with	with	ADP
admet-2874	240	6	antifibrotic	antifibrotic	ADJ
admet-2874	240	7	agents	agent	NOUN
admet-2874	240	8	in	in	ADP
admet-2874	240	9	clinical	clinical	ADJ
admet-2874	240	10	trials	trial	NOUN
admet-2874	240	11	may	may	AUX
admet-2874	240	12	represent	represent	VERB
admet-2874	240	13	a	a	DET
admet-2874	240	14	promising	promising	ADJ
admet-2874	240	15	avenue	avenue	NOUN
admet-2874	240	16	to	to	PART
admet-2874	240	17	enhance	enhance	VERB
admet-2874	240	18	therapeutic	therapeutic	ADJ
admet-2874	240	19	success	success	NOUN
admet-2874	240	20	and	and	CCONJ
admet-2874	240	21	clinical	clinical	ADJ
admet-2874	240	22	translation	translation	NOUN
admet-2874	240	23	.	.	PUNCT
admet-2874	241	1	ultimately	ultimately	ADV
admet-2874	241	2	,	,	PUNCT
admet-2874	241	3	such	such	ADJ
admet-2874	241	4	advancements	advancement	NOUN
admet-2874	241	5	aim	aim	VERB
admet-2874	241	6	to	to	PART
admet-2874	241	7	improve	improve	VERB
admet-2874	241	8	patient	patient	ADJ
admet-2874	241	9	outcomes	outcome	NOUN
admet-2874	241	10	and	and	CCONJ
admet-2874	241	11	overall	overall	ADJ
admet-2874	241	12	quality	quality	NOUN
admet-2874	241	13	of	of	ADP
admet-2874	241	14	life	life	NOUN
admet-2874	241	15	.	.	PUNCT
admet-2874	242	1	future	future	ADJ
admet-2874	242	2	directions	direction	NOUN
admet-2874	242	3	hscs	hsc	NOUN
admet-2874	242	4	have	have	AUX
admet-2874	242	5	emerged	emerge	VERB
admet-2874	242	6	as	as	ADP
admet-2874	242	7	a	a	DET
admet-2874	242	8	promising	promising	ADJ
admet-2874	242	9	and	and	CCONJ
admet-2874	242	10	important	important	ADJ
admet-2874	242	11	target	target	NOUN
admet-2874	242	12	for	for	ADP
admet-2874	242	13	treating	treat	VERB
admet-2874	242	14	liver	liver	NOUN
admet-2874	242	15	fibrosis	fibrosis	NOUN
admet-2874	242	16	,	,	PUNCT
admet-2874	242	17	leading	lead	VERB
admet-2874	242	18	to	to	ADP
admet-2874	242	19	a	a	DET
admet-2874	242	20	complex	complex	ADJ
admet-2874	242	21	yet	yet	ADV
admet-2874	242	22	promising	promising	ADJ
admet-2874	242	23	area	area	NOUN
admet-2874	242	24	of	of	ADP
admet-2874	242	25	research	research	NOUN
admet-2874	242	26	.	.	PUNCT
admet-2874	243	1	hscs	hsc	NOUN
admet-2874	243	2	play	play	VERB
admet-2874	243	3	a	a	DET
admet-2874	243	4	central	central	ADJ
admet-2874	243	5	role	role	NOUN
admet-2874	243	6	in	in	ADP
admet-2874	243	7	fibrogenesis	fibrogenesis	NOUN
admet-2874	243	8	after	after	ADP
admet-2874	243	9	activation	activation	NOUN
admet-2874	243	10	in	in	ADP
admet-2874	243	11	response	response	NOUN
admet-2874	243	12	to	to	ADP
admet-2874	243	13	liver	liver	NOUN
admet-2874	243	14	insult	insult	NOUN
admet-2874	243	15	,	,	PUNCT
admet-2874	243	16	and	and	CCONJ
admet-2874	243	17	express	express	VERB
admet-2874	243	18	excess	excess	ADJ
admet-2874	243	19	extracellular	extracellular	ADJ
admet-2874	243	20	matrix	matrix	NOUN
admet-2874	243	21	proteins	protein	NOUN
admet-2874	243	22	.	.	PUNCT
admet-2874	244	1	however	however	ADV
admet-2874	244	2	,	,	PUNCT
admet-2874	244	3	potential	potential	ADJ
admet-2874	244	4	challenges	challenge	NOUN
admet-2874	244	5	impede	impede	VERB
admet-2874	244	6	the	the	DET
admet-2874	244	7	development	development	NOUN
admet-2874	244	8	of	of	ADP
admet-2874	244	9	effective	effective	ADJ
admet-2874	244	10	therapies	therapy	NOUN
admet-2874	244	11	.	.	PUNCT
admet-2874	245	1	primarily	primarily	ADV
admet-2874	245	2	,	,	PUNCT
admet-2874	245	3	because	because	SCONJ
admet-2874	245	4	hscs	hscs	ADJ
admet-2874	245	5	share	share	NOUN
admet-2874	245	6	surface	surface	NOUN
admet-2874	245	7	markers	marker	NOUN
admet-2874	245	8	with	with	ADP
admet-2874	245	9	other	other	ADJ
admet-2874	245	10	cell	cell	NOUN
admet-2874	245	11	types	type	NOUN
admet-2874	245	12	,	,	PUNCT
admet-2874	245	13	leading	lead	VERB
admet-2874	245	14	to	to	ADP
admet-2874	245	15	potential	potential	ADJ
admet-2874	245	16	off	off	ADP
admet-2874	245	17	-	-	PUNCT
admet-2874	245	18	target	target	NOUN
admet-2874	245	19	effects	effect	NOUN
admet-2874	245	20	.	.	PUNCT
admet-2874	246	1	another	another	DET
admet-2874	246	2	challenge	challenge	NOUN
admet-2874	246	3	arises	arise	VERB
admet-2874	246	4	because	because	SCONJ
admet-2874	246	5	hscs	hsc	NOUN
admet-2874	246	6	are	be	AUX
admet-2874	246	7	diverse	diverse	ADJ
admet-2874	246	8	cells	cell	NOUN
admet-2874	246	9	that	that	PRON
admet-2874	246	10	exhibit	exhibit	VERB
admet-2874	246	11	unique	unique	ADJ
admet-2874	246	12	phenotypes	phenotype	NOUN
admet-2874	246	13	depending	depend	VERB
admet-2874	246	14	on	on	ADP
admet-2874	246	15	their	their	PRON
admet-2874	246	16	location	location	NOUN
admet-2874	246	17	in	in	ADP
admet-2874	246	18	the	the	DET
admet-2874	246	19	tissue	tissue	NOUN
admet-2874	246	20	and	and	CCONJ
admet-2874	246	21	the	the	DET
admet-2874	246	22	disease	disease	NOUN
admet-2874	246	23	state	state	NOUN
admet-2874	246	24	,	,	PUNCT
admet-2874	246	25	which	which	PRON
admet-2874	246	26	complicates	complicate	VERB
admet-2874	246	27	the	the	DET
admet-2874	246	28	design	design	NOUN
admet-2874	246	29	and	and	CCONJ
admet-2874	246	30	development	development	NOUN
admet-2874	246	31	of	of	ADP
admet-2874	246	32	universal	universal	ADJ
admet-2874	246	33	therapeutic	therapeutic	ADJ
admet-2874	246	34	options	option	NOUN
admet-2874	246	35	.	.	PUNCT
admet-2874	247	1	furthermore	furthermore	ADV
admet-2874	247	2	,	,	PUNCT
admet-2874	247	3	the	the	DET
admet-2874	247	4	reversibility	reversibility	NOUN
admet-2874	247	5	of	of	ADP
admet-2874	247	6	fibrosis	fibrosis	NOUN
admet-2874	247	7	varies	vary	VERB
admet-2874	247	8	,	,	PUNCT
admet-2874	247	9	with	with	ADP
admet-2874	247	10	advanced	advanced	ADJ
admet-2874	247	11	stages	stage	NOUN
admet-2874	247	12	posing	pose	VERB
admet-2874	247	13	greater	great	ADJ
admet-2874	247	14	resistance	resistance	NOUN
admet-2874	247	15	to	to	ADP
admet-2874	247	16	therapeutic	therapeutic	ADJ
admet-2874	247	17	intervention	intervention	NOUN
admet-2874	247	18	.	.	PUNCT
admet-2874	248	1	additionally	additionally	ADV
admet-2874	248	2	,	,	PUNCT
admet-2874	248	3	efficient	efficient	ADJ
admet-2874	248	4	drug	drug	NOUN
admet-2874	248	5	delivery	delivery	NOUN
admet-2874	248	6	to	to	PART
admet-2874	248	7	liver	liver	NOUN
admet-2874	248	8	tissue	tissue	NOUN
admet-2874	248	9	is	be	AUX
admet-2874	248	10	hindered	hinder	VERB
admet-2874	248	11	by	by	ADP
admet-2874	248	12	the	the	DET
admet-2874	248	13	liver	liver	NOUN
admet-2874	248	14	’s	’s	PART
admet-2874	248	15	complex	complex	ADJ
admet-2874	248	16	anatomy	anatomy	NOUN
admet-2874	248	17	and	and	CCONJ
admet-2874	248	18	the	the	DET
admet-2874	248	19	presence	presence	NOUN
admet-2874	248	20	of	of	ADP
admet-2874	248	21	varying	vary	VERB
admet-2874	248	22	levels	level	NOUN
admet-2874	248	23	of	of	ADP
admet-2874	248	24	the	the	DET
admet-2874	248	25	fibrotic	fibrotic	ADJ
admet-2874	248	26	matrix	matrix	NOUN
admet-2874	248	27	within	within	ADP
admet-2874	248	28	the	the	DET
admet-2874	248	29	tissue	tissue	NOUN
admet-2874	248	30	.	.	PUNCT
admet-2874	249	1	the	the	DET
admet-2874	249	2	major	major	ADJ
admet-2874	249	3	hurdle	hurdle	NOUN
admet-2874	249	4	in	in	ADP
admet-2874	249	5	the	the	DET
admet-2874	249	6	treatment	treatment	NOUN
admet-2874	249	7	monitoring	monitoring	NOUN
admet-2874	249	8	aspect	aspect	NOUN
admet-2874	249	9	is	be	AUX
admet-2874	249	10	the	the	DET
admet-2874	249	11	lack	lack	NOUN
admet-2874	249	12	of	of	ADP
admet-2874	249	13	reliable	reliable	ADJ
admet-2874	249	14	,	,	PUNCT
admet-2874	249	15	non	non	ADJ
admet-2874	249	16	-	-	ADJ
admet-2874	249	17	invasive	invasive	ADJ
admet-2874	249	18	biomarkers	biomarker	NOUN
admet-2874	249	19	for	for	ADP
admet-2874	249	20	hsc	hsc	NOUN
admet-2874	249	21	activation	activation	NOUN
admet-2874	249	22	,	,	PUNCT
admet-2874	249	23	resulting	result	VERB
admet-2874	249	24	in	in	ADP
admet-2874	249	25	poor	poor	ADJ
admet-2874	249	26	treatment	treatment	NOUN
admet-2874	249	27	monitoring	monitoring	NOUN
admet-2874	249	28	.	.	PUNCT
admet-2874	250	1	moreover	moreover	ADV
admet-2874	250	2	,	,	PUNCT
admet-2874	250	3	the	the	DET
admet-2874	250	4	redundancy	redundancy	NOUN
admet-2874	250	5	in	in	ADP
admet-2874	250	6	fibrogenic	fibrogenic	ADJ
admet-2874	250	7	signalling	signal	VERB
admet-2874	250	8	pathways	pathway	NOUN
admet-2874	250	9	leads	lead	VERB
admet-2874	250	10	to	to	ADP
admet-2874	250	11	the	the	DET
admet-2874	250	12	fact	fact	NOUN
admet-2874	250	13	that	that	SCONJ
admet-2874	250	14	targeting	target	VERB
admet-2874	250	15	a	a	DET
admet-2874	250	16	single	single	ADJ
admet-2874	250	17	molecular	molecular	ADJ
admet-2874	250	18	pathway	pathway	NOUN
admet-2874	250	19	often	often	ADV
admet-2874	250	20	fails	fail	VERB
admet-2874	250	21	to	to	PART
admet-2874	250	22	halt	halt	VERB
admet-2874	250	23	disease	disease	NOUN
admet-2874	250	24	progression	progression	NOUN
admet-2874	250	25	.	.	PUNCT
admet-2874	251	1	this	this	PRON
admet-2874	251	2	is	be	AUX
admet-2874	251	3	a	a	DET
admet-2874	251	4	crucial	crucial	ADJ
admet-2874	251	5	factor	factor	NOUN
admet-2874	251	6	influencing	influence	VERB
admet-2874	251	7	the	the	DET
admet-2874	251	8	translation	translation	NOUN
admet-2874	251	9	of	of	ADP
admet-2874	251	10	promising	promise	VERB
admet-2874	251	11	experimental	experimental	ADJ
admet-2874	251	12	therapies	therapy	NOUN
admet-2874	251	13	into	into	ADP
admet-2874	251	14	a	a	DET
admet-2874	251	15	clinical	clinical	ADJ
admet-2874	251	16	setting	setting	NOUN
admet-2874	251	17	.	.	PUNCT
admet-2874	252	1	this	this	PRON
admet-2874	252	2	is	be	AUX
admet-2874	252	3	evident	evident	ADJ
admet-2874	252	4	by	by	ADP
admet-2874	252	5	analysing	analyse	VERB
admet-2874	252	6	the	the	DET
admet-2874	252	7	successful	successful	ADJ
admet-2874	252	8	progression	progression	NOUN
admet-2874	252	9	of	of	ADP
admet-2874	252	10	clinical	clinical	ADJ
admet-2874	252	11	trials	trial	NOUN
admet-2874	252	12	through	through	ADP
admet-2874	252	13	various	various	ADJ
admet-2874	252	14	stages	stage	NOUN
admet-2874	252	15	and	and	CCONJ
admet-2874	252	16	regulatory	regulatory	ADJ
admet-2874	252	17	approval	approval	NOUN
admet-2874	252	18	for	for	ADP
admet-2874	252	19	clinical	clinical	ADJ
admet-2874	252	20	use	use	NOUN
admet-2874	252	21	.	.	PUNCT
admet-2874	253	1	researchers	researcher	NOUN
admet-2874	253	2	are	be	AUX
admet-2874	253	3	exploring	explore	VERB
admet-2874	253	4	ways	way	NOUN
admet-2874	253	5	to	to	PART
admet-2874	253	6	control	control	VERB
admet-2874	253	7	hscimmune	hscimmune	NOUN
admet-2874	253	8	cell	cell	NOUN
admet-2874	253	9	interactions	interaction	NOUN
admet-2874	253	10	,	,	PUNCT
admet-2874	253	11	restore	restore	VERB
admet-2874	253	12	hsc	hsc	NOUN
admet-2874	253	13	quiescence	quiescence	NOUN
admet-2874	253	14	,	,	PUNCT
admet-2874	253	15	or	or	CCONJ
admet-2874	253	16	trigger	trigger	VERB
admet-2874	253	17	their	their	PRON
admet-2874	253	18	apoptosis	apoptosis	NOUN
admet-2874	253	19	to	to	PART
admet-2874	253	20	combat	combat	VERB
admet-2874	253	21	liver	liver	NOUN
admet-2874	253	22	fibrosis	fibrosis	NOUN
admet-2874	253	23	.	.	PUNCT
admet-2874	254	1	artificial	artificial	ADJ
admet-2874	254	2	intelligence	intelligence	NOUN
admet-2874	254	3	(	(	PUNCT
admet-2874	254	4	ai	ai	NOUN
admet-2874	254	5	)	)	PUNCT
admet-2874	254	6	and	and	CCONJ
admet-2874	254	7	computational	computational	ADJ
admet-2874	254	8	tools	tool	NOUN
admet-2874	254	9	are	be	AUX
admet-2874	254	10	enhancing	enhance	VERB
admet-2874	254	11	therapy	therapy	NOUN
admet-2874	254	12	design	design	NOUN
admet-2874	254	13	,	,	PUNCT
admet-2874	254	14	while	while	SCONJ
admet-2874	254	15	improved	improved	ADJ
admet-2874	254	16	models	model	NOUN
admet-2874	254	17	like	like	ADP
admet-2874	254	18	humanized	humanize	VERB
admet-2874	254	19	mice	mouse	NOUN
admet-2874	254	20	and	and	CCONJ
admet-2874	254	21	organ	organ	NOUN
admet-2874	254	22	-	-	PUNCT
admet-2874	254	23	on	on	ADP
admet-2874	254	24	-	-	PUNCT
admet-2874	254	25	chip	chip	NOUN
admet-2874	254	26	systems	system	NOUN
admet-2874	254	27	are	be	AUX
admet-2874	254	28	advancing	advance	VERB
admet-2874	254	29	drug	drug	NOUN
admet-2874	254	30	testing	testing	NOUN
admet-2874	254	31	.	.	PUNCT
admet-2874	255	1	these	these	DET
admet-2874	255	2	strategies	strategy	NOUN
admet-2874	255	3	aim	aim	VERB
admet-2874	255	4	to	to	PART
admet-2874	255	5	develop	develop	VERB
admet-2874	255	6	more	more	ADV
admet-2874	255	7	effective	effective	ADJ
admet-2874	255	8	and	and	CCONJ
admet-2874	255	9	targeted	target	VERB
admet-2874	255	10	treatments	treatment	NOUN
admet-2874	255	11	.	.	PUNCT
admet-2874	256	1	to	to	PART
admet-2874	256	2	address	address	VERB
admet-2874	256	3	these	these	DET
admet-2874	256	4	challenges	challenge	NOUN
admet-2874	256	5	,	,	PUNCT
admet-2874	256	6	future	future	ADJ
admet-2874	256	7	research	research	NOUN
admet-2874	256	8	should	should	AUX
admet-2874	256	9	focus	focus	VERB
admet-2874	256	10	on	on	ADP
admet-2874	256	11	several	several	ADJ
admet-2874	256	12	innovative	innovative	ADJ
admet-2874	256	13	strategies	strategy	NOUN
admet-2874	256	14	,	,	PUNCT
admet-2874	256	15	including	include	VERB
admet-2874	256	16	precision	precision	NOUN
admet-2874	256	17	delivery	delivery	NOUN
admet-2874	256	18	systems	system	NOUN
admet-2874	256	19	such	such	ADJ
admet-2874	256	20	as	as	ADP
admet-2874	256	21	actively	actively	ADV
admet-2874	256	22	targeted	target	VERB
admet-2874	256	23	nanocarriers	nanocarrier	NOUN
admet-2874	256	24	loaded	load	VERB
admet-2874	256	25	with	with	ADP
admet-2874	256	26	more	more	ADJ
admet-2874	256	27	than	than	ADP
admet-2874	256	28	one	one	NUM
admet-2874	256	29	therapeutic	therapeutic	ADJ
admet-2874	256	30	molecule	molecule	NOUN
admet-2874	256	31	,	,	PUNCT
admet-2874	256	32	nanoparticles	nanoparticle	NOUN
admet-2874	256	33	,	,	PUNCT
admet-2874	256	34	and	and	CCONJ
admet-2874	256	35	antibody	antibody	NOUN
admet-2874	256	36	-	-	PUNCT
admet-2874	256	37	drug	drug	NOUN
admet-2874	256	38	conjugates	conjugate	NOUN
admet-2874	256	39	,	,	PUNCT
admet-2874	256	40	which	which	PRON
admet-2874	256	41	are	be	AUX
admet-2874	256	42	being	be	AUX
admet-2874	256	43	developed	develop	VERB
admet-2874	256	44	to	to	PART
admet-2874	256	45	selectively	selectively	ADV
admet-2874	256	46	target	target	VERB
admet-2874	256	47	activated	activate	VERB
admet-2874	256	48	hscs	hsc	NOUN
admet-2874	256	49	.	.	PUNCT
admet-2874	257	1	gene	gene	NOUN
admet-2874	257	2	editing	editing	NOUN
admet-2874	257	3	tools	tool	NOUN
admet-2874	257	4	,	,	PUNCT
admet-2874	257	5	such	such	ADJ
admet-2874	257	6	as	as	ADP
admet-2874	257	7	crispr	crispr	NOUN
admet-2874	257	8	/	/	SYM
admet-2874	257	9	cas9	cas9	NOUN
admet-2874	257	10	and	and	CCONJ
admet-2874	257	11	rna	rna	NOUN
admet-2874	257	12	-	-	PUNCT
admet-2874	257	13	based	base	VERB
admet-2874	257	14	therapeutics	therapeutic	NOUN
admet-2874	257	15	,	,	PUNCT
admet-2874	257	16	offer	offer	VERB
admet-2874	257	17	potential	potential	NOUN
admet-2874	257	18	for	for	ADP
admet-2874	257	19	modulating	modulate	VERB
admet-2874	257	20	key	key	ADJ
admet-2874	257	21	fibrogenic	fibrogenic	ADJ
admet-2874	257	22	genes	gene	NOUN
admet-2874	257	23	and	and	CCONJ
admet-2874	257	24	can	can	AUX
admet-2874	257	25	be	be	AUX
admet-2874	257	26	used	use	VERB
admet-2874	257	27	to	to	PART
admet-2874	257	28	target	target	VERB
admet-2874	257	29	multiple	multiple	ADJ
admet-2874	257	30	pathways	pathway	NOUN
admet-2874	257	31	,	,	PUNCT
admet-2874	257	32	thereby	thereby	ADV
admet-2874	257	33	mitigating	mitigate	VERB
admet-2874	257	34	liver	liver	NOUN
admet-2874	257	35	fibrosis	fibrosis	NOUN
admet-2874	257	36	and	and	CCONJ
admet-2874	257	37	its	its	PRON
admet-2874	257	38	progression	progression	NOUN
admet-2874	257	39	to	to	PART
admet-2874	257	40	liver	liver	NOUN
admet-2874	257	41	cancer	cancer	NOUN
admet-2874	257	42	.	.	PUNCT
admet-2874	258	1	advances	advance	NOUN
admet-2874	258	2	in	in	ADP
admet-2874	258	3	single	single	ADJ
admet-2874	258	4	-	-	PUNCT
admet-2874	258	5	cell	cell	NOUN
admet-2874	258	6	transcriptomics	transcriptomic	NOUN
admet-2874	258	7	and	and	CCONJ
admet-2874	258	8	spatial	spatial	ADJ
admet-2874	258	9	omics	omic	NOUN
admet-2874	258	10	studies	study	NOUN
admet-2874	258	11	can	can	AUX
admet-2874	258	12	be	be	AUX
admet-2874	258	13	helpful	helpful	ADJ
admet-2874	258	14	in	in	ADP
admet-2874	258	15	two	two	NUM
admet-2874	258	16	ways	way	NOUN
admet-2874	258	17	,	,	PUNCT
admet-2874	258	18	as	as	SCONJ
admet-2874	258	19	these	these	DET
admet-2874	258	20	studies	study	NOUN
admet-2874	258	21	can	can	AUX
admet-2874	258	22	improve	improve	VERB
admet-2874	258	23	understanding	understanding	NOUN
admet-2874	258	24	of	of	ADP
admet-2874	258	25	hsc	hsc	PROPN
admet-2874	258	26	heterogeneity	heterogeneity	NOUN
admet-2874	258	27	,	,	PUNCT
admet-2874	258	28	leading	lead	VERB
admet-2874	258	29	to	to	ADP
admet-2874	258	30	a	a	DET
admet-2874	258	31	better	well	ADJ
admet-2874	258	32	understanding	understanding	NOUN
admet-2874	258	33	of	of	ADP
admet-2874	258	34	unique	unique	ADJ
admet-2874	258	35	phenotypes	phenotype	NOUN
admet-2874	258	36	based	base	VERB
admet-2874	258	37	upon	upon	SCONJ
admet-2874	258	38	location	location	NOUN
admet-2874	258	39	and	and	CCONJ
admet-2874	258	40	tissue	tissue	NOUN
admet-2874	258	41	,	,	PUNCT
admet-2874	258	42	paving	pave	VERB
admet-2874	258	43	the	the	DET
admet-2874	258	44	way	way	NOUN
admet-2874	258	45	for	for	ADP
admet-2874	258	46	personalized	personalized	ADJ
admet-2874	258	47	treatments	treatment	NOUN
admet-2874	258	48	.	.	PUNCT
admet-2874	259	1	combination	combination	NOUN
admet-2874	259	2	therapies	therapy	NOUN
admet-2874	259	3	that	that	PRON
admet-2874	259	4	target	target	VERB
admet-2874	259	5	multiple	multiple	ADJ
admet-2874	259	6	pathways	pathway	NOUN
admet-2874	259	7	or	or	CCONJ
admet-2874	259	8	integrate	integrate	VERB
admet-2874	259	9	anti	anti	ADJ
admet-2874	259	10	-	-	ADJ
admet-2874	259	11	inflammatory	inflammatory	ADJ
admet-2874	259	12	and	and	CCONJ
admet-2874	259	13	regenerative	regenerative	ADJ
admet-2874	259	14	approaches	approach	NOUN
admet-2874	259	15	may	may	AUX
admet-2874	259	16	enhance	enhance	VERB
admet-2874	259	17	efficacy	efficacy	NOUN
admet-2874	259	18	and	and	CCONJ
admet-2874	259	19	improve	improve	VERB
admet-2874	259	20	therapeutic	therapeutic	ADJ
admet-2874	259	21	outcomes	outcome	NOUN
admet-2874	259	22	.	.	PUNCT
admet-2874	260	1	additionally	additionally	ADV
admet-2874	260	2	,	,	PUNCT
admet-2874	260	3	modulating	modulate	VERB
admet-2874	260	4	hsc	hsc	NOUN
admet-2874	260	5	-	-	PUNCT
admet-2874	260	6	immune	immune	ADJ
admet-2874	260	7	cell	cell	NOUN
admet-2874	260	8	interactions	interaction	NOUN
admet-2874	260	9	and	and	CCONJ
admet-2874	260	10	promoting	promote	VERB
admet-2874	260	11	either	either	CCONJ
admet-2874	260	12	the	the	DET
admet-2874	260	13	reversion	reversion	NOUN
admet-2874	260	14	of	of	ADP
admet-2874	260	15	hscs	hsc	NOUN
admet-2874	260	16	to	to	ADP
admet-2874	260	17	a	a	DET
admet-2874	260	18	quiescent	quiescent	ADJ
admet-2874	260	19	state	state	NOUN
admet-2874	260	20	or	or	CCONJ
admet-2874	260	21	their	their	PRON
admet-2874	260	22	selective	selective	ADJ
admet-2874	260	23	apoptosis	apoptosis	NOUN
admet-2874	260	24	are	be	AUX
admet-2874	260	25	being	be	AUX
admet-2874	260	26	explored	explore	VERB
admet-2874	260	27	.	.	PUNCT
admet-2874	261	1	computational	computational	ADJ
admet-2874	261	2	modelling	modelling	NOUN
admet-2874	261	3	and	and	CCONJ
admet-2874	261	4	ai	ai	VERB
admet-2874	261	5	will	will	AUX
admet-2874	261	6	also	also	ADV
admet-2874	261	7	be	be	AUX
admet-2874	261	8	crucial	crucial	ADJ
admet-2874	261	9	for	for	ADP
admet-2874	261	10	analysing	analyse	VERB
admet-2874	261	11	data	datum	NOUN
admet-2874	261	12	generated	generate	VERB
admet-2874	261	13	admet	admet	PROPN
admet-2874	261	14	&	&	CCONJ
admet-2874	261	15	dmpk	dmpk	PROPN
admet-2874	261	16	13(4	13(4	NUM
admet-2874	261	17	)	)	PUNCT
admet-2874	261	18	(	(	PUNCT
admet-2874	261	19	2025	2025	NUM
admet-2874	261	20	)	)	PUNCT
admet-2874	261	21	2874	2874	NUM
admet-2874	261	22	hscs	hsc	NOUN
admet-2874	261	23	in	in	ADP
admet-2874	261	24	liver	liver	NOUN
admet-2874	261	25	fibrosis	fibrosis	NOUN
admet-2874	261	26	:	:	PUNCT
admet-2874	261	27	therapeutic	therapeutic	ADJ
admet-2874	261	28	advances	advance	NOUN
admet-2874	261	29	doi	doi	NOUN
admet-2874	261	30	:	:	PUNCT
admet-2874	261	31	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	261	32	15	15	NUM
admet-2874	261	33	from	from	ADP
admet-2874	261	34	single	single	ADJ
admet-2874	261	35	-	-	PUNCT
admet-2874	261	36	cell	cell	NOUN
admet-2874	261	37	sequencing	sequence	VERB
admet-2874	261	38	data	datum	NOUN
admet-2874	261	39	for	for	ADP
admet-2874	261	40	the	the	DET
admet-2874	261	41	identification	identification	NOUN
admet-2874	261	42	of	of	ADP
admet-2874	261	43	potential	potential	ADJ
admet-2874	261	44	novel	novel	ADJ
admet-2874	261	45	targets	target	NOUN
admet-2874	261	46	,	,	PUNCT
admet-2874	261	47	and	and	CCONJ
admet-2874	261	48	a	a	DET
admet-2874	261	49	better	well	ADJ
admet-2874	261	50	understanding	understanding	NOUN
admet-2874	261	51	of	of	ADP
admet-2874	261	52	the	the	DET
admet-2874	261	53	disease	disease	NOUN
admet-2874	261	54	mechanism	mechanism	NOUN
admet-2874	261	55	will	will	AUX
admet-2874	261	56	also	also	ADV
admet-2874	261	57	be	be	AUX
admet-2874	261	58	an	an	DET
admet-2874	261	59	important	important	ADJ
admet-2874	261	60	aspect	aspect	NOUN
admet-2874	261	61	in	in	ADP
admet-2874	261	62	optimizing	optimize	VERB
admet-2874	261	63	therapeutic	therapeutic	ADJ
admet-2874	261	64	strategies	strategy	NOUN
admet-2874	261	65	.	.	PUNCT
admet-2874	262	1	in	in	ADP
admet-2874	262	2	brief	brief	ADJ
admet-2874	262	3	,	,	PUNCT
admet-2874	262	4	future	future	ADJ
admet-2874	262	5	directions	direction	NOUN
admet-2874	262	6	will	will	AUX
admet-2874	262	7	be	be	AUX
admet-2874	262	8	guided	guide	VERB
admet-2874	262	9	by	by	ADP
admet-2874	262	10	advanced	advanced	ADJ
admet-2874	262	11	techniques	technique	NOUN
admet-2874	262	12	,	,	PUNCT
admet-2874	262	13	including	include	VERB
admet-2874	262	14	single	single	ADJ
admet-2874	262	15	-	-	PUNCT
admet-2874	262	16	cell	cell	NOUN
admet-2874	262	17	transcriptome	transcriptome	ADJ
admet-2874	262	18	analysis	analysis	NOUN
admet-2874	262	19	and	and	CCONJ
admet-2874	262	20	ai	ai	VERB
admet-2874	262	21	and	and	CCONJ
admet-2874	262	22	machine	machine	NOUN
admet-2874	262	23	learning	learning	NOUN
admet-2874	262	24	,	,	PUNCT
admet-2874	262	25	to	to	PART
admet-2874	262	26	identify	identify	VERB
admet-2874	262	27	novel	novel	ADJ
admet-2874	262	28	therapeutic	therapeutic	ADJ
admet-2874	262	29	targets	target	NOUN
admet-2874	262	30	and	and	CCONJ
admet-2874	262	31	options	option	NOUN
admet-2874	262	32	for	for	ADP
admet-2874	262	33	treating	treat	VERB
admet-2874	262	34	liver	liver	NOUN
admet-2874	262	35	fibrosis	fibrosis	NOUN
admet-2874	262	36	.	.	PUNCT
admet-2874	263	1	acknowledgment	acknowledgment	NOUN
admet-2874	263	2	:	:	PUNCT
admet-2874	263	3	the	the	DET
admet-2874	263	4	authors	author	NOUN
admet-2874	263	5	are	be	AUX
admet-2874	263	6	thankful	thankful	ADJ
admet-2874	263	7	to	to	ADP
admet-2874	263	8	upes	upe	NOUN
admet-2874	263	9	dehradun	dehradun	PROPN
admet-2874	263	10	,	,	PUNCT
admet-2874	263	11	india	india	PROPN
admet-2874	263	12	,	,	PUNCT
admet-2874	263	13	for	for	ADP
admet-2874	263	14	providing	provide	VERB
admet-2874	263	15	a	a	DET
admet-2874	263	16	phd	phd	NOUN
admet-2874	263	17	fellowship	fellowship	NOUN
admet-2874	263	18	to	to	ADP
admet-2874	263	19	ms	ms	PROPN
admet-2874	263	20	.	.	PROPN
admet-2874	263	21	alka	alka	PROPN
admet-2874	263	22	funding	funding	PROPN
admet-2874	263	23	:	:	PUNCT
admet-2874	263	24	the	the	DET
admet-2874	263	25	authors	author	NOUN
admet-2874	263	26	have	have	AUX
admet-2874	263	27	received	receive	VERB
admet-2874	263	28	no	no	DET
admet-2874	263	29	specific	specific	ADJ
admet-2874	263	30	grant	grant	NOUN
admet-2874	263	31	from	from	ADP
admet-2874	263	32	any	any	DET
admet-2874	263	33	funding	funding	NOUN
admet-2874	263	34	agency	agency	NOUN
admet-2874	263	35	in	in	ADP
admet-2874	263	36	the	the	DET
admet-2874	263	37	public	public	ADJ
admet-2874	263	38	,	,	PUNCT
admet-2874	263	39	commercial	commercial	ADJ
admet-2874	263	40	or	or	CCONJ
admet-2874	263	41	not	not	PART
admet-2874	263	42	-	-	PUNCT
admet-2874	263	43	for	for	ADP
admet-2874	263	44	-	-	PUNCT
admet-2874	263	45	profit	profit	NOUN
admet-2874	263	46	sectors	sector	NOUN
admet-2874	263	47	.	.	PUNCT
admet-2874	264	1	author	author	NOUN
admet-2874	264	2	contributions	contribution	NOUN
admet-2874	264	3	:	:	PUNCT
admet-2874	264	4	all	all	DET
admet-2874	264	5	authors	author	NOUN
admet-2874	264	6	contributed	contribute	VERB
admet-2874	264	7	to	to	ADP
admet-2874	264	8	the	the	DET
admet-2874	264	9	study	study	NOUN
admet-2874	264	10	conception	conception	NOUN
admet-2874	264	11	and	and	CCONJ
admet-2874	264	12	design	design	NOUN
admet-2874	264	13	.	.	PUNCT
admet-2874	265	1	data	datum	NOUN
admet-2874	265	2	collection	collection	NOUN
admet-2874	265	3	and	and	CCONJ
admet-2874	265	4	analysis	analysis	NOUN
admet-2874	265	5	were	be	AUX
admet-2874	265	6	performed	perform	VERB
admet-2874	265	7	by	by	ADP
admet-2874	265	8	alka	alka	NOUN
admet-2874	265	9	and	and	CCONJ
admet-2874	265	10	ansab	ansab	VERB
admet-2874	265	11	akhtar	akhtar	PROPN
admet-2874	265	12	.	.	PUNCT
admet-2874	266	1	prashant	prashant	PROPN
admet-2874	266	2	shukla	shukla	PROPN
admet-2874	266	3	supervised	supervise	VERB
admet-2874	266	4	all	all	DET
admet-2874	266	5	phases	phase	NOUN
admet-2874	266	6	of	of	ADP
admet-2874	266	7	the	the	DET
admet-2874	266	8	study	study	NOUN
admet-2874	266	9	,	,	PUNCT
admet-2874	266	10	including	include	VERB
admet-2874	266	11	manuscript	manuscript	NOUN
admet-2874	266	12	writing	writing	NOUN
admet-2874	266	13	.	.	PUNCT
admet-2874	267	1	all	all	DET
admet-2874	267	2	authors	author	NOUN
admet-2874	267	3	have	have	AUX
admet-2874	267	4	read	read	VERB
admet-2874	267	5	and	and	CCONJ
admet-2874	267	6	agreed	agree	VERB
admet-2874	267	7	to	to	ADP
admet-2874	267	8	the	the	DET
admet-2874	267	9	published	publish	VERB
admet-2874	267	10	version	version	NOUN
admet-2874	267	11	of	of	ADP
admet-2874	267	12	the	the	DET
admet-2874	267	13	manuscript	manuscript	NOUN
admet-2874	267	14	.	.	PUNCT
admet-2874	268	1	ethics	ethic	NOUN
admet-2874	268	2	approval	approval	NOUN
admet-2874	268	3	and	and	CCONJ
admet-2874	268	4	consent	consent	NOUN
admet-2874	268	5	to	to	PART
admet-2874	268	6	participate	participate	VERB
admet-2874	268	7	:	:	PUNCT
admet-2874	268	8	not	not	PART
admet-2874	268	9	applicable	applicable	ADJ
admet-2874	268	10	.	.	PUNCT
admet-2874	269	1	consent	consent	NOUN
admet-2874	269	2	to	to	PART
admet-2874	269	3	participate	participate	VERB
admet-2874	269	4	:	:	PUNCT
admet-2874	269	5	not	not	PART
admet-2874	269	6	applicable	applicable	ADJ
admet-2874	269	7	.	.	PUNCT
admet-2874	270	1	consent	consent	NOUN
admet-2874	270	2	to	to	PART
admet-2874	270	3	publish	publish	VERB
admet-2874	270	4	:	:	PUNCT
admet-2874	270	5	not	not	PART
admet-2874	270	6	applicable	applicable	ADJ
admet-2874	270	7	data	datum	NOUN
admet-2874	270	8	availability	availability	NOUN
admet-2874	270	9	:	:	PUNCT
admet-2874	270	10	not	not	PART
admet-2874	270	11	applicable	applicable	ADJ
admet-2874	270	12	due	due	ADP
admet-2874	270	13	to	to	ADP
admet-2874	270	14	the	the	DET
admet-2874	270	15	review	review	NOUN
admet-2874	270	16	article	article	NOUN
admet-2874	270	17	.	.	PUNCT
admet-2874	271	1	conflicts	conflict	NOUN
admet-2874	271	2	of	of	ADP
admet-2874	271	3	interest	interest	NOUN
admet-2874	271	4	:	:	PUNCT
admet-2874	271	5	the	the	DET
admet-2874	271	6	authors	author	NOUN
admet-2874	271	7	declare	declare	VERB
admet-2874	271	8	no	no	DET
admet-2874	271	9	conflicts	conflict	NOUN
admet-2874	271	10	of	of	ADP
admet-2874	271	11	interest	interest	NOUN
admet-2874	271	12	.	.	PUNCT
admet-2874	272	1	references	reference	NOUN
admet-2874	272	2	1	1	NUM
admet-2874	272	3	.	.	PUNCT
admet-2874	272	4	m.	m.	PROPN
admet-2874	272	5	zamani	zamani	PROPN
admet-2874	272	6	,	,	PUNCT
admet-2874	272	7	s.	s.	PROPN
admet-2874	272	8	alizadeh	alizadeh	PROPN
admet-2874	272	9	-	-	PUNCT
admet-2874	272	10	tabari	tabari	PROPN
admet-2874	272	11	,	,	PUNCT
admet-2874	272	12	v.	v.	ADP
admet-2874	272	13	ajmera	ajmera	PROPN
admet-2874	272	14	,	,	PUNCT
admet-2874	272	15	s.	s.	PROPN
admet-2874	272	16	singh	singh	PROPN
admet-2874	272	17	,	,	PUNCT
admet-2874	272	18	m.h	m.h	PROPN
admet-2874	272	19	.	.	PROPN
admet-2874	272	20	murad	murad	PROPN
admet-2874	272	21	,	,	PUNCT
admet-2874	272	22	r.	r.	PROPN
admet-2874	272	23	loomba	loomba	PROPN
admet-2874	272	24	.	.	PUNCT
admet-2874	273	1	global	global	ADJ
admet-2874	273	2	prevalence	prevalence	NOUN
admet-2874	273	3	of	of	ADP
admet-2874	273	4	advanced	advanced	ADJ
admet-2874	273	5	liver	liver	NOUN
admet-2874	273	6	fibrosis	fibrosis	NOUN
admet-2874	273	7	and	and	CCONJ
admet-2874	273	8	cirrhosis	cirrhosis	NOUN
admet-2874	273	9	in	in	ADP
admet-2874	273	10	the	the	DET
admet-2874	273	11	general	general	ADJ
admet-2874	273	12	population	population	NOUN
admet-2874	273	13	:	:	PUNCT
admet-2874	273	14	a	a	DET
admet-2874	273	15	systematic	systematic	ADJ
admet-2874	273	16	review	review	NOUN
admet-2874	273	17	and	and	CCONJ
admet-2874	273	18	meta	meta	ADJ
admet-2874	273	19	-	-	PUNCT
admet-2874	273	20	analysis	analysis	NOUN
admet-2874	273	21	.	.	PUNCT
admet-2874	274	1	clinical	clinical	ADJ
admet-2874	274	2	gastroenterology	gastroenterology	NOUN
admet-2874	274	3	and	and	CCONJ
admet-2874	274	4	hepatology	hepatology	NOUN
admet-2874	274	5	23	23	NUM
admet-2874	274	6	(	(	PUNCT
admet-2874	274	7	2025	2025	NUM
admet-2874	274	8	)	)	PUNCT
admet-2874	274	9	1123	1123	NUM
admet-2874	274	10	-	-	SYM
admet-2874	274	11	1134	1134	NUM
admet-2874	274	12	.	.	PUNCT
admet-2874	275	1	https://doi.org/10.1016/j.cgh.2024.08.020	https://doi.org/10.1016/j.cgh.2024.08.020	NOUN
admet-2874	275	2	2	2	NUM
admet-2874	275	3	.	.	PUNCT
admet-2874	276	1	v.	v.	PROPN
admet-2874	276	2	tiwari	tiwari	PROPN
admet-2874	276	3	,	,	PUNCT
admet-2874	276	4	s.	s.	PROPN
admet-2874	276	5	shandily	shandily	PROPN
admet-2874	276	6	,	,	PUNCT
admet-2874	276	7	j.	j.	PROPN
admet-2874	276	8	albert	albert	PROPN
admet-2874	276	9	,	,	PUNCT
admet-2874	276	10	v.	v.	PROPN
admet-2874	276	11	mishra	mishra	PROPN
admet-2874	276	12	,	,	PUNCT
admet-2874	276	13	m.	m.	NOUN
admet-2874	276	14	dikkatwar	dikkatwar	PROPN
admet-2874	276	15	,	,	PUNCT
admet-2874	276	16	r.	r.	PROPN
admet-2874	276	17	singh	singh	PROPN
admet-2874	276	18	,	,	PUNCT
admet-2874	276	19	s.k	s.k	PROPN
admet-2874	276	20	.	.	PROPN
admet-2874	276	21	sah	sah	PROPN
admet-2874	276	22	,	,	PUNCT
admet-2874	276	23	s.	s.	PROPN
admet-2874	276	24	chand	chand	PROPN
admet-2874	276	25	.	.	PUNCT
admet-2874	277	1	insights	insight	NOUN
admet-2874	277	2	into	into	ADP
admet-2874	277	3	medication	medication	NOUN
admet-2874	277	4	-	-	PUNCT
admet-2874	277	5	induced	induce	VERB
admet-2874	277	6	liver	liver	NOUN
admet-2874	277	7	injury	injury	NOUN
admet-2874	277	8	:	:	PUNCT
admet-2874	277	9	understanding	understanding	NOUN
admet-2874	277	10	and	and	CCONJ
admet-2874	277	11	management	management	NOUN
admet-2874	277	12	strategies	strategy	NOUN
admet-2874	277	13	.	.	PUNCT
admet-2874	278	1	toxicology	toxicology	NOUN
admet-2874	278	2	reports	report	VERB
admet-2874	278	3	14	14	NUM
admet-2874	278	4	(	(	PUNCT
admet-2874	278	5	2025	2025	NUM
admet-2874	278	6	)	)	PUNCT
admet-2874	278	7	101976	101976	NUM
admet-2874	278	8	.	.	PUNCT
admet-2874	279	1	https://doi.org/10.1016/j.toxrep.2025.101976	https://doi.org/10.1016/j.toxrep.2025.101976	NOUN
admet-2874	279	2	3	3	NUM
admet-2874	279	3	.	.	PUNCT
admet-2874	279	4	j.c.t	j.c.t	PROPN
admet-2874	279	5	.	.	PUNCT
admet-2874	280	1	lai	lai	PROPN
admet-2874	280	2	,	,	PUNCT
admet-2874	280	3	l.y	l.y	PROPN
admet-2874	280	4	.	.	PROPN
admet-2874	280	5	liang	liang	PROPN
admet-2874	280	6	,	,	PUNCT
admet-2874	280	7	g.	g.	PROPN
admet-2874	280	8	lai	lai	PROPN
admet-2874	280	9	-	-	PUNCT
admet-2874	280	10	hung	hung	PROPN
admet-2874	280	11	wong	wong	PROPN
admet-2874	280	12	.	.	PROPN
admet-2874	280	13	noninvasive	noninvasive	ADJ
admet-2874	280	14	tests	test	NOUN
admet-2874	280	15	for	for	ADP
admet-2874	280	16	liver	liver	NOUN
admet-2874	280	17	fibrosis	fibrosis	NOUN
admet-2874	280	18	in	in	ADP
admet-2874	280	19	2024	2024	NUM
admet-2874	280	20	:	:	PUNCT
admet-2874	280	21	are	be	AUX
admet-2874	280	22	there	there	PRON
admet-2874	280	23	different	different	ADJ
admet-2874	280	24	scales	scale	NOUN
admet-2874	280	25	for	for	ADP
admet-2874	280	26	different	different	ADJ
admet-2874	280	27	diseases	disease	NOUN
admet-2874	280	28	?	?	PUNCT
admet-2874	281	1	gastroenterology	gastroenterology	NOUN
admet-2874	281	2	report	report	NOUN
admet-2874	281	3	12	12	NUM
admet-2874	281	4	(	(	PUNCT
admet-2874	281	5	2023	2023	NUM
admet-2874	281	6	)	)	PUNCT
admet-2874	281	7	goae096	goae096	NOUN
admet-2874	281	8	.	.	PUNCT
admet-2874	282	1	https://doi.org/10.1093/gastro/goae024	https://doi.org/10.1093/gastro/goae024	NOUN
admet-2874	282	2	4	4	NUM
admet-2874	282	3	.	.	PUNCT
admet-2874	282	4	w.	w.	PROPN
admet-2874	282	5	seo	seo	PROPN
admet-2874	282	6	,	,	PUNCT
admet-2874	282	7	w.i	w.i	PROPN
admet-2874	282	8	.	.	PROPN
admet-2874	282	9	jeong	jeong	PROPN
admet-2874	282	10	.	.	PUNCT
admet-2874	283	1	hepatic	hepatic	ADJ
admet-2874	283	2	non	non	ADJ
admet-2874	283	3	-	-	ADJ
admet-2874	283	4	parenchymal	parenchymal	ADJ
admet-2874	283	5	cells	cell	NOUN
admet-2874	283	6	:	:	PUNCT
admet-2874	283	7	master	master	NOUN
admet-2874	283	8	regulators	regulator	NOUN
admet-2874	283	9	of	of	ADP
admet-2874	283	10	alcoholic	alcoholic	ADJ
admet-2874	283	11	liver	liver	NOUN
admet-2874	283	12	disease	disease	NOUN
admet-2874	283	13	?	?	PUNCT
admet-2874	284	1	world	world	PROPN
admet-2874	284	2	journal	journal	PROPN
admet-2874	284	3	of	of	ADP
admet-2874	284	4	gastroenterology	gastroenterology	NOUN
admet-2874	284	5	22	22	NUM
admet-2874	284	6	(	(	PUNCT
admet-2874	284	7	2016	2016	NUM
admet-2874	284	8	)	)	PUNCT
admet-2874	284	9	1348	1348	NUM
admet-2874	284	10	-	-	SYM
admet-2874	284	11	1356	1356	NUM
admet-2874	284	12	.	.	PUNCT
admet-2874	285	1	https://doi.org/10.3748/wjg.v22.i4.1348	https://doi.org/10.3748/wjg.v22.i4.1348	PROPN
admet-2874	285	2	5	5	NUM
admet-2874	285	3	.	.	PUNCT
admet-2874	286	1	j.m	j.m	PROPN
admet-2874	286	2	.	.	PROPN
admet-2874	286	3	banales	banale	NOUN
admet-2874	286	4	,	,	PUNCT
admet-2874	286	5	r.c	r.c	PROPN
admet-2874	286	6	.	.	PROPN
admet-2874	286	7	huebert	huebert	PROPN
admet-2874	286	8	,	,	PUNCT
admet-2874	286	9	t.	t.	PROPN
admet-2874	286	10	karlsen	karlsen	PROPN
admet-2874	286	11	,	,	PUNCT
admet-2874	286	12	m.	m.	PROPN
admet-2874	286	13	strazzabosco	strazzabosco	PROPN
admet-2874	286	14	,	,	PUNCT
admet-2874	286	15	n.f	n.f	PROPN
admet-2874	286	16	.	.	PROPN
admet-2874	286	17	larusso	larusso	PROPN
admet-2874	286	18	,	,	PUNCT
admet-2874	286	19	g.j	g.j	PROPN
admet-2874	286	20	.	.	PROPN
admet-2874	286	21	gores	gore	NOUN
admet-2874	286	22	.	.	PUNCT
admet-2874	287	1	cholangiocyte	cholangiocyte	PROPN
admet-2874	287	2	pathobiology	pathobiology	NOUN
admet-2874	287	3	.	.	PUNCT
admet-2874	288	1	nature	nature	NOUN
admet-2874	288	2	reviews	review	VERB
admet-2874	288	3	gastroenterology	gastroenterology	NOUN
admet-2874	288	4	and	and	CCONJ
admet-2874	288	5	hepatology	hepatology	NOUN
admet-2874	288	6	16	16	NUM
admet-2874	288	7	(	(	PUNCT
admet-2874	288	8	2019	2019	NUM
admet-2874	288	9	)	)	PUNCT
admet-2874	288	10	269	269	NUM
admet-2874	288	11	-	-	SYM
admet-2874	288	12	281	281	NUM
admet-2874	288	13	.	.	PUNCT
admet-2874	289	1	https://doi.org/10.1038/s41575-019-0125-y	https://doi.org/10.1038/s41575-019-0125-y	PROPN
admet-2874	289	2	6	6	NUM
admet-2874	289	3	.	.	PUNCT
admet-2874	290	1	j.	j.	PROPN
admet-2874	290	2	behmoaras	behmoaras	PROPN
admet-2874	290	3	,	,	PUNCT
admet-2874	290	4	k.	k.	PROPN
admet-2874	290	5	mulder	mulder	PROPN
admet-2874	290	6	,	,	PUNCT
admet-2874	290	7	f.	f.	PROPN
admet-2874	290	8	ginhoux	ginhoux	PROPN
admet-2874	290	9	,	,	PUNCT
admet-2874	290	10	e.	e.	PROPN
admet-2874	290	11	petretto	petretto	PROPN
admet-2874	290	12	.	.	PUNCT
admet-2874	291	1	the	the	DET
admet-2874	291	2	spatial	spatial	ADJ
admet-2874	291	3	and	and	CCONJ
admet-2874	291	4	temporal	temporal	ADJ
admet-2874	291	5	activation	activation	NOUN
admet-2874	291	6	of	of	ADP
admet-2874	291	7	macrophages	macrophage	NOUN
admet-2874	291	8	during	during	ADP
admet-2874	291	9	fibrosis	fibrosis	NOUN
admet-2874	291	10	.	.	PUNCT
admet-2874	292	1	nature	nature	NOUN
admet-2874	292	2	reviews	review	VERB
admet-2874	292	3	immunology	immunology	NOUN
admet-2874	292	4	(	(	PUNCT
admet-2874	292	5	2025	2025	NUM
admet-2874	292	6	)	)	PUNCT
admet-2874	292	7	.	.	PUNCT
admet-2874	293	1	https://doi.org/10.1038/s41577-025-01186-x	https://doi.org/10.1038/s41577-025-01186-x	NOUN
admet-2874	293	2	7	7	NUM
admet-2874	293	3	.	.	PUNCT
admet-2874	294	1	y.	y.	PROPN
admet-2874	294	2	wan	wan	PROPN
admet-2874	294	3	,	,	PUNCT
admet-2874	294	4	f.	f.	PROPN
admet-2874	294	5	meng	meng	PROPN
admet-2874	294	6	,	,	PUNCT
admet-2874	294	7	n.	n.	PROPN
admet-2874	294	8	wu	wu	PROPN
admet-2874	294	9	,	,	PUNCT
admet-2874	294	10	t.	t.	PROPN
admet-2874	294	11	zhou	zhou	PROPN
admet-2874	294	12	,	,	PUNCT
admet-2874	294	13	j.	j.	PROPN
admet-2874	294	14	venter	venter	PROPN
admet-2874	294	15	,	,	PUNCT
admet-2874	294	16	h.	h.	PROPN
admet-2874	294	17	francis	francis	PROPN
admet-2874	294	18	,	,	PUNCT
admet-2874	294	19	l.	l.	PROPN
admet-2874	294	20	kennedy	kennedy	PROPN
admet-2874	294	21	,	,	PUNCT
admet-2874	294	22	t.	t.	PROPN
admet-2874	294	23	glaser	glaser	PROPN
admet-2874	294	24	,	,	PUNCT
admet-2874	294	25	f.	f.	PROPN
admet-2874	294	26	bernuzzi	bernuzzi	PROPN
admet-2874	294	27	,	,	PUNCT
admet-2874	294	28	p.	p.	PROPN
admet-2874	294	29	invernizzi	invernizzi	PROPN
admet-2874	294	30	,	,	PUNCT
admet-2874	294	31	s.	s.	PROPN
admet-2874	294	32	glaser	glaser	PROPN
admet-2874	294	33	,	,	PUNCT
admet-2874	294	34	q.	q.	PROPN
admet-2874	294	35	huang	huang	PROPN
admet-2874	294	36	,	,	PUNCT
admet-2874	294	37	g.	g.	PROPN
admet-2874	294	38	alpini	alpini	PROPN
admet-2874	294	39	.	.	PUNCT
admet-2874	295	1	substance	substance	NOUN
admet-2874	295	2	p	p	NOUN
admet-2874	295	3	increases	increase	VERB
admet-2874	295	4	liver	liver	NOUN
admet-2874	295	5	fibrosis	fibrosis	NOUN
admet-2874	295	6	by	by	ADP
admet-2874	295	7	differential	differential	ADJ
admet-2874	295	8	changes	change	NOUN
admet-2874	295	9	in	in	ADP
admet-2874	295	10	senescence	senescence	NOUN
admet-2874	295	11	of	of	ADP
admet-2874	295	12	cholangiocytes	cholangiocyte	NOUN
admet-2874	295	13	and	and	CCONJ
admet-2874	295	14	hepatic	hepatic	ADJ
admet-2874	295	15	stellate	stellate	ADJ
admet-2874	295	16	cells	cell	NOUN
admet-2874	295	17	.	.	PUNCT
admet-2874	296	1	hepatology	hepatology	NOUN
admet-2874	296	2	66	66	NUM
admet-2874	296	3	(	(	PUNCT
admet-2874	296	4	2017	2017	NUM
admet-2874	296	5	)	)	PUNCT
admet-2874	296	6	528	528	NUM
admet-2874	296	7	-	-	SYM
admet-2874	296	8	541	541	NUM
admet-2874	296	9	.	.	PUNCT
admet-2874	297	1	https://doi.org/10.1002/hep.29138	https://doi.org/10.1002/hep.29138	PROPN
admet-2874	297	2	8	8	NUM
admet-2874	297	3	.	.	PUNCT
admet-2874	298	1	n.j	n.j	PROPN
admet-2874	298	2	.	.	PROPN
admet-2874	298	3	hunt	hunt	PROPN
admet-2874	298	4	,	,	PUNCT
admet-2874	298	5	p.a.g	p.a.g	PROPN
admet-2874	298	6	.	.	PUNCT
admet-2874	299	1	mccourt	mccourt	PROPN
admet-2874	299	2	,	,	PUNCT
admet-2874	299	3	d.g.le	d.g.le	NOUN
admet-2874	299	4	couteur	couteur	PROPN
admet-2874	299	5	,	,	PUNCT
admet-2874	299	6	v.c	v.c	PROPN
admet-2874	299	7	.	.	PROPN
admet-2874	299	8	cogger	cogger	NOUN
admet-2874	299	9	.	.	PUNCT
admet-2874	300	1	novel	novel	ADJ
admet-2874	300	2	targets	target	NOUN
admet-2874	300	3	for	for	ADP
admet-2874	300	4	delaying	delay	VERB
admet-2874	300	5	aging	aging	NOUN
admet-2874	300	6	:	:	PUNCT
admet-2874	300	7	the	the	DET
admet-2874	300	8	importance	importance	NOUN
admet-2874	300	9	of	of	ADP
admet-2874	300	10	the	the	DET
admet-2874	300	11	liver	liver	NOUN
admet-2874	300	12	and	and	CCONJ
admet-2874	300	13	advances	advance	NOUN
admet-2874	300	14	in	in	ADP
admet-2874	300	15	drug	drug	NOUN
admet-2874	300	16	delivery	delivery	NOUN
admet-2874	300	17	.	.	PUNCT
admet-2874	301	1	advanced	advanced	ADJ
admet-2874	301	2	drug	drug	NOUN
admet-2874	301	3	delivery	delivery	NOUN
admet-2874	301	4	reviews	review	VERB
admet-2874	301	5	135	135	NUM
admet-2874	301	6	(	(	PUNCT
admet-2874	301	7	2018	2018	NUM
admet-2874	301	8	)	)	PUNCT
admet-2874	301	9	39	39	NUM
admet-2874	301	10	-	-	SYM
admet-2874	301	11	49	49	NUM
admet-2874	301	12	.	.	PUNCT
admet-2874	302	1	https://doi.org/10.1016/j.addr.2018.09.006	https://doi.org/10.1016/j.addr.2018.09.006	ADJ
admet-2874	302	2	9	9	NUM
admet-2874	302	3	.	.	PUNCT
admet-2874	303	1	j.	j.	PROPN
admet-2874	303	2	gracia	gracia	PROPN
admet-2874	303	3	-	-	PUNCT
admet-2874	303	4	sancho	sancho	PROPN
admet-2874	303	5	,	,	PUNCT
admet-2874	303	6	e.	e.	PROPN
admet-2874	303	7	caparrós	caparrós	PROPN
admet-2874	303	8	,	,	PUNCT
admet-2874	303	9	a.	a.	PROPN
admet-2874	303	10	fernández	fernández	PROPN
admet-2874	303	11	-	-	PUNCT
admet-2874	303	12	iglesias	iglesias	PROPN
admet-2874	303	13	,	,	PUNCT
admet-2874	303	14	r.	r.	PROPN
admet-2874	303	15	francés	francés	PROPN
admet-2874	303	16	.	.	PUNCT
admet-2874	304	1	role	role	NOUN
admet-2874	304	2	of	of	ADP
admet-2874	304	3	liver	liver	NOUN
admet-2874	304	4	sinusoidal	sinusoidal	NOUN
admet-2874	304	5	endothelial	endothelial	NOUN
admet-2874	304	6	cells	cell	NOUN
admet-2874	304	7	in	in	ADP
admet-2874	304	8	liver	liver	NOUN
admet-2874	304	9	diseases	disease	NOUN
admet-2874	304	10	.	.	PUNCT
admet-2874	305	1	nature	nature	NOUN
admet-2874	305	2	reviews	review	VERB
admet-2874	305	3	gastroenterology	gastroenterology	NOUN
admet-2874	305	4	and	and	CCONJ
admet-2874	305	5	hepatology	hepatology	NOUN
admet-2874	305	6	18	18	NUM
admet-2874	305	7	(	(	PUNCT
admet-2874	305	8	2021	2021	NUM
admet-2874	305	9	)	)	PUNCT
admet-2874	305	10	411	411	NUM
admet-2874	305	11	-	-	SYM
admet-2874	305	12	431	431	NUM
admet-2874	305	13	.	.	PUNCT
admet-2874	306	1	https://doi.org/10.1038/s41575-020-00411-3	https://doi.org/10.1038/s41575-020-00411-3	NUM
admet-2874	306	2	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	VERB
admet-2874	306	3	https://doi.org/10.1016/j.cgh.2024.08.020	https://doi.org/10.1016/j.cgh.2024.08.020	PROPN
admet-2874	306	4	https://doi.org/10.1016/j.toxrep.2025.101976	https://doi.org/10.1016/j.toxrep.2025.101976	NOUN
admet-2874	306	5	https://doi.org/10.1093/gastro/goae024	https://doi.org/10.1093/gastro/goae024	NOUN
admet-2874	307	1	https://doi.org/10.3748/wjg.v22.i4.1348	https://doi.org/10.3748/wjg.v22.i4.1348	PROPN
admet-2874	307	2	https://doi.org/10.1038/s41575-019-0125-y	https://doi.org/10.1038/s41575-019-0125-y	PROPN
admet-2874	308	1	https://doi.org/10.1038/s41577-025-01186-x	https://doi.org/10.1038/s41577-025-01186-x	PROPN
admet-2874	308	2	https://doi.org/10.1002/hep.29138	https://doi.org/10.1002/hep.29138	PROPN
admet-2874	308	3	https://doi.org/10.1038/s41575-020-00411-3	https://doi.org/10.1038/s41575-020-00411-3	NUM
admet-2874	308	4	a.	a.	NOUN
admet-2874	308	5	singh	singh	PROPN
admet-2874	308	6	et	et	PROPN
admet-2874	308	7	al	al	PROPN
admet-2874	308	8	.	.	PROPN
admet-2874	308	9	admet	admet	PROPN
admet-2874	308	10	&	&	CCONJ
admet-2874	308	11	dmpk	dmpk	PROPN
admet-2874	308	12	13(4	13(4	NUM
admet-2874	308	13	)	)	PUNCT
admet-2874	308	14	(	(	PUNCT
admet-2874	308	15	2025	2025	NUM
admet-2874	308	16	)	)	PUNCT
admet-2874	308	17	2874	2874	NUM
admet-2874	308	18	16	16	NUM
admet-2874	308	19	10	10	NUM
admet-2874	308	20	.	.	PUNCT
admet-2874	309	1	y.	y.	PROPN
admet-2874	309	2	wei	wei	PROPN
admet-2874	309	3	,	,	PUNCT
admet-2874	309	4	w.	w.	PROPN
admet-2874	309	5	bingyu	bingyu	PROPN
admet-2874	309	6	,	,	PUNCT
admet-2874	309	7	y.	y.	PROPN
admet-2874	309	8	lei	lei	PROPN
admet-2874	309	9	,	,	PUNCT
admet-2874	309	10	y.	y.	PROPN
admet-2874	309	11	xingxing	xingxing	PROPN
admet-2874	309	12	.	.	PUNCT
admet-2874	310	1	the	the	DET
admet-2874	310	2	antifibrotic	antifibrotic	ADJ
admet-2874	310	3	role	role	NOUN
admet-2874	310	4	of	of	ADP
admet-2874	310	5	natural	natural	ADJ
admet-2874	310	6	killer	killer	NOUN
admet-2874	310	7	cells	cell	NOUN
admet-2874	310	8	in	in	ADP
admet-2874	310	9	liver	liver	NOUN
admet-2874	310	10	fibrosis	fibrosis	NOUN
admet-2874	310	11	.	.	PUNCT
admet-2874	311	1	experimental	experimental	ADJ
admet-2874	311	2	biology	biology	NOUN
admet-2874	311	3	and	and	CCONJ
admet-2874	311	4	medicine	medicine	NOUN
admet-2874	311	5	247	247	NUM
admet-2874	311	6	(	(	PUNCT
admet-2874	311	7	2022	2022	NUM
admet-2874	311	8	)	)	PUNCT
admet-2874	311	9	1235	1235	NUM
admet-2874	311	10	-	-	SYM
admet-2874	311	11	1243	1243	NUM
admet-2874	311	12	.	.	PUNCT
admet-2874	312	1	https://doi.org/10.1177/15353702221092672	https://doi.org/10.1177/15353702221092672	X
admet-2874	312	2	11	11	NUM
admet-2874	312	3	.	.	PUNCT
admet-2874	313	1	e.	e.	PROPN
admet-2874	313	2	slevin	slevin	PROPN
admet-2874	313	3	,	,	PUNCT
admet-2874	313	4	l.	l.	PROPN
admet-2874	313	5	baiocchi	baiocchi	PROPN
admet-2874	313	6	,	,	PUNCT
admet-2874	313	7	n.	n.	PROPN
admet-2874	313	8	wu	wu	PROPN
admet-2874	313	9	,	,	PUNCT
admet-2874	313	10	b.	b.	PROPN
admet-2874	313	11	ekser	ekser	PROPN
admet-2874	313	12	,	,	PUNCT
admet-2874	313	13	k.	k.	PROPN
admet-2874	313	14	sato	sato	PROPN
admet-2874	313	15	,	,	PUNCT
admet-2874	313	16	e.	e.	PROPN
admet-2874	313	17	lin	lin	PROPN
admet-2874	313	18	,	,	PUNCT
admet-2874	313	19	l.	l.	PROPN
admet-2874	313	20	ceci	ceci	PROPN
admet-2874	313	21	,	,	PUNCT
admet-2874	313	22	l.	l.	PROPN
admet-2874	313	23	chen	chen	PROPN
admet-2874	313	24	,	,	PUNCT
admet-2874	313	25	s.r	s.r	PROPN
admet-2874	313	26	.	.	PROPN
admet-2874	313	27	lorenzo	lorenzo	PROPN
admet-2874	313	28	,	,	PUNCT
admet-2874	313	29	w.	w.	PROPN
admet-2874	313	30	xu	xu	PROPN
admet-2874	313	31	,	,	PUNCT
admet-2874	313	32	k.	k.	PROPN
admet-2874	313	33	kyritsi	kyritsi	PROPN
admet-2874	313	34	,	,	PUNCT
admet-2874	313	35	v.	v.	ADP
admet-2874	313	36	meadows	meadow	NOUN
admet-2874	313	37	,	,	PUNCT
admet-2874	313	38	t.	t.	PROPN
admet-2874	313	39	zhou	zhou	PROPN
admet-2874	313	40	,	,	PUNCT
admet-2874	313	41	d.	d.	PROPN
admet-2874	313	42	kundu	kundu	PROPN
admet-2874	313	43	,	,	PUNCT
admet-2874	313	44	y.	y.	PROPN
admet-2874	313	45	han	han	PROPN
admet-2874	313	46	,	,	PUNCT
admet-2874	313	47	l.	l.	PROPN
admet-2874	313	48	kennedy	kennedy	PROPN
admet-2874	313	49	,	,	PUNCT
admet-2874	313	50	s.	s.	PROPN
admet-2874	313	51	glaser	glaser	PROPN
admet-2874	313	52	,	,	PUNCT
admet-2874	313	53	h.	h.	PROPN
admet-2874	313	54	francis	francis	PROPN
admet-2874	313	55	,	,	PUNCT
admet-2874	313	56	g.	g.	PROPN
admet-2874	313	57	alpini	alpini	PROPN
admet-2874	313	58	,	,	PUNCT
admet-2874	313	59	f.	f.	PROPN
admet-2874	313	60	meng	meng	PROPN
admet-2874	313	61	.	.	PUNCT
admet-2874	314	1	kupffer	kupffer	PROPN
admet-2874	314	2	cells	cell	NOUN
admet-2874	314	3	:	:	PUNCT
admet-2874	314	4	inflammation	inflammation	NOUN
admet-2874	314	5	pathways	pathway	NOUN
admet-2874	314	6	and	and	CCONJ
admet-2874	314	7	cell	cell	NOUN
admet-2874	314	8	-	-	PUNCT
admet-2874	314	9	cell	cell	NOUN
admet-2874	314	10	interactions	interaction	NOUN
admet-2874	314	11	in	in	ADP
admet-2874	314	12	alcohol	alcohol	NOUN
admet-2874	314	13	-	-	PUNCT
admet-2874	314	14	associated	associate	VERB
admet-2874	314	15	liver	liver	NOUN
admet-2874	314	16	disease	disease	NOUN
admet-2874	314	17	.	.	PUNCT
admet-2874	315	1	the	the	DET
admet-2874	315	2	american	american	PROPN
admet-2874	315	3	journal	journal	PROPN
admet-2874	315	4	of	of	ADP
admet-2874	315	5	pathology	pathology	PROPN
admet-2874	315	6	190	190	NUM
admet-2874	315	7	(	(	PUNCT
admet-2874	315	8	2020	2020	NUM
admet-2874	315	9	)	)	PUNCT
admet-2874	315	10	2185	2185	NUM
admet-2874	315	11	-	-	SYM
admet-2874	315	12	2193	2193	NUM
admet-2874	315	13	.	.	PUNCT
admet-2874	316	1	https://doi.org/10.1016/j.ajpath.2020.08.014	https://doi.org/10.1016/j.ajpath.2020.08.014	PRON
admet-2874	316	2	12	12	NUM
admet-2874	316	3	.	.	PUNCT
admet-2874	317	1	y.	y.	PROPN
admet-2874	317	2	wan	wan	PROPN
admet-2874	317	3	,	,	PUNCT
admet-2874	317	4	w.	w.	PROPN
admet-2874	317	5	zhang	zhang	PROPN
admet-2874	317	6	,	,	PUNCT
admet-2874	317	7	c.	c.	PROPN
admet-2874	317	8	huang	huang	PROPN
admet-2874	317	9	,	,	PUNCT
admet-2874	317	10	j.	j.	PROPN
admet-2874	317	11	jian	jian	PROPN
admet-2874	317	12	,	,	PUNCT
admet-2874	317	13	y.	y.	PROPN
admet-2874	317	14	zhang	zhang	PROPN
admet-2874	317	15	,	,	PUNCT
admet-2874	317	16	q.	q.	PROPN
admet-2874	317	17	liu	liu	PROPN
admet-2874	317	18	,	,	PUNCT
admet-2874	317	19	p.	p.	PROPN
admet-2874	317	20	chen	chen	PROPN
admet-2874	317	21	,	,	PUNCT
admet-2874	317	22	x.	x.	PROPN
admet-2874	317	23	zhu	zhu	PROPN
admet-2874	317	24	.	.	PUNCT
admet-2874	318	1	ursolic	ursolic	ADJ
admet-2874	318	2	acid	acid	NOUN
admet-2874	318	3	alleviates	alleviate	VERB
admet-2874	318	4	kupffer	kupffer	NOUN
admet-2874	318	5	cells	cell	NOUN
admet-2874	318	6	pyroptosis	pyroptosis	NOUN
admet-2874	318	7	in	in	ADP
admet-2874	318	8	liver	liver	NOUN
admet-2874	318	9	fibrosis	fibrosis	NOUN
admet-2874	318	10	by	by	ADP
admet-2874	318	11	the	the	DET
admet-2874	318	12	nox2	nox2	PROPN
admet-2874	318	13	/	/	SYM
admet-2874	318	14	nlrp3	nlrp3	NOUN
admet-2874	318	15	inflammasome	inflammasome	NOUN
admet-2874	318	16	signaling	signal	VERB
admet-2874	318	17	pathway	pathway	NOUN
admet-2874	318	18	.	.	PUNCT
admet-2874	319	1	international	international	ADJ
admet-2874	319	2	immonopharmacology	immonopharmacology	NOUN
admet-2874	319	3	113	113	NUM
admet-2874	319	4	(	(	PUNCT
admet-2874	319	5	2022	2022	NUM
admet-2874	319	6	)	)	PUNCT
admet-2874	319	7	109321	109321	NUM
admet-2874	319	8	.	.	PUNCT
admet-2874	320	1	https://doi.org/10.1016/j.intimp.2022.109321	https://doi.org/10.1016/j.intimp.2022.109321	ADJ
admet-2874	320	2	13	13	NUM
admet-2874	320	3	.	.	PUNCT
admet-2874	321	1	y.	y.	PROPN
admet-2874	321	2	zhou	zhou	PROPN
admet-2874	321	3	,	,	PUNCT
admet-2874	321	4	d.	d.	PROPN
admet-2874	321	5	long	long	PROPN
admet-2874	321	6	,	,	PUNCT
admet-2874	321	7	y.	y.	PROPN
admet-2874	321	8	zhao	zhao	PROPN
admet-2874	321	9	,	,	PUNCT
admet-2874	321	10	s.	s.	PROPN
admet-2874	321	11	li	li	PROPN
admet-2874	321	12	,	,	PUNCT
admet-2874	321	13	y.	y.	PROPN
admet-2874	321	14	liang	liang	PROPN
admet-2874	321	15	,	,	PUNCT
admet-2874	321	16	l.	l.	PROPN
admet-2874	321	17	wan	wan	PROPN
admet-2874	321	18	,	,	PUNCT
admet-2874	321	19	j.	j.	PROPN
admet-2874	321	20	zhang	zhang	PROPN
admet-2874	321	21	,	,	PUNCT
admet-2874	321	22	f.	f.	PROPN
admet-2874	321	23	xue	xue	PROPN
admet-2874	321	24	,	,	PUNCT
admet-2874	321	25	l.	l.	PROPN
admet-2874	321	26	feng	feng	PROPN
admet-2874	321	27	.	.	PUNCT
admet-2874	322	1	oxidative	oxidative	ADJ
admet-2874	322	2	stressmediated	stressmediate	VERB
admet-2874	322	3	mitochondrial	mitochondrial	ADJ
admet-2874	322	4	fission	fission	NOUN
admet-2874	322	5	promotes	promote	VERB
admet-2874	322	6	hepatic	hepatic	ADJ
admet-2874	322	7	stellate	stellate	ADJ
admet-2874	322	8	cell	cell	NOUN
admet-2874	322	9	activation	activation	NOUN
admet-2874	322	10	via	via	ADP
admet-2874	322	11	stimulating	stimulate	VERB
admet-2874	322	12	oxidative	oxidative	ADJ
admet-2874	322	13	phosphorylation	phosphorylation	NOUN
admet-2874	322	14	.	.	PUNCT
admet-2874	323	1	cell	cell	NOUN
admet-2874	323	2	death	death	NOUN
admet-2874	323	3	disease	disease	NOUN
admet-2874	323	4	13	13	NUM
admet-2874	323	5	(	(	PUNCT
admet-2874	323	6	2022	2022	NUM
admet-2874	323	7	)	)	PUNCT
admet-2874	323	8	689	689	NUM
admet-2874	323	9	.	.	PUNCT
admet-2874	324	1	https://doi.org/10.1038/s41419-022-05088-x	https://doi.org/10.1038/s41419-022-05088-x	PROPN
admet-2874	324	2	14	14	NUM
admet-2874	324	3	.	.	PUNCT
admet-2874	325	1	j.	j.	PROPN
admet-2874	325	2	plakkal	plakkal	PROPN
admet-2874	325	3	ayyappan	ayyappan	PROPN
admet-2874	325	4	,	,	PUNCT
admet-2874	325	5	a.	a.	PROPN
admet-2874	325	6	paul	paul	PROPN
admet-2874	325	7	,	,	PUNCT
admet-2874	325	8	y.h	y.h	PROPN
admet-2874	325	9	.	.	PROPN
admet-2874	325	10	goo	goo	PROPN
admet-2874	325	11	.	.	PUNCT
admet-2874	326	1	lipid	lipid	PROPN
admet-2874	326	2	droplet	droplet	ADJ
admet-2874	326	3	-	-	PUNCT
admet-2874	326	4	associated	associate	VERB
admet-2874	326	5	proteins	protein	NOUN
admet-2874	326	6	in	in	ADP
admet-2874	326	7	atherosclerosis	atherosclerosis	NOUN
admet-2874	326	8	(	(	PUNCT
admet-2874	326	9	review	review	NOUN
admet-2874	326	10	)	)	PUNCT
admet-2874	326	11	.	.	PUNCT
admet-2874	327	1	molecular	molecular	ADJ
admet-2874	327	2	medicine	medicine	NOUN
admet-2874	327	3	reports	report	VERB
admet-2874	327	4	13	13	NUM
admet-2874	327	5	(	(	PUNCT
admet-2874	327	6	2016	2016	NUM
admet-2874	327	7	)	)	PUNCT
admet-2874	327	8	4527	4527	NUM
admet-2874	327	9	-	-	SYM
admet-2874	327	10	4534	4534	NUM
admet-2874	327	11	.	.	PUNCT
admet-2874	328	1	https://doi.org/10.3892/mmr.2016.5099	https://doi.org/10.3892/mmr.2016.5099	PROPN
admet-2874	328	2	15	15	NUM
admet-2874	328	3	.	.	PUNCT
admet-2874	329	1	t.f	t.f	PROPN
admet-2874	329	2	.	.	PROPN
admet-2874	329	3	lee	lee	PROPN
admet-2874	329	4	,	,	PUNCT
admet-2874	329	5	k.m	k.m	PROPN
admet-2874	329	6	.	.	PROPN
admet-2874	329	7	mak	mak	PROPN
admet-2874	329	8	,	,	PUNCT
admet-2874	329	9	o.	o.	NOUN
admet-2874	329	10	rackovsky	rackovsky	NOUN
admet-2874	329	11	,	,	PUNCT
admet-2874	329	12	y.l	y.l	PROPN
admet-2874	329	13	.	.	PROPN
admet-2874	329	14	lin	lin	PROPN
admet-2874	329	15	,	,	PUNCT
admet-2874	329	16	a.j	a.j	PROPN
admet-2874	329	17	.	.	PROPN
admet-2874	329	18	kwong	kwong	PROPN
admet-2874	329	19	,	,	PUNCT
admet-2874	329	20	j.c	j.c	PROPN
admet-2874	329	21	.	.	PROPN
admet-2874	329	22	loke	loke	PROPN
admet-2874	329	23	,	,	PUNCT
admet-2874	329	24	s.l	s.l	PROPN
admet-2874	329	25	.	.	PROPN
admet-2874	329	26	friedman	friedman	PROPN
admet-2874	329	27	.	.	PUNCT
admet-2874	330	1	downregulation	downregulation	NOUN
admet-2874	330	2	of	of	ADP
admet-2874	330	3	hepatic	hepatic	ADJ
admet-2874	330	4	stellate	stellate	ADJ
admet-2874	330	5	cell	cell	NOUN
admet-2874	330	6	activation	activation	NOUN
admet-2874	330	7	by	by	ADP
admet-2874	330	8	retinol	retinol	NOUN
admet-2874	330	9	and	and	CCONJ
admet-2874	330	10	palmitate	palmitate	NOUN
admet-2874	330	11	mediated	mediate	VERB
admet-2874	330	12	by	by	ADP
admet-2874	330	13	adipose	adipose	ADJ
admet-2874	330	14	differentiation	differentiation	NOUN
admet-2874	330	15	-	-	PUNCT
admet-2874	330	16	related	relate	VERB
admet-2874	330	17	protein	protein	NOUN
admet-2874	330	18	(	(	PUNCT
admet-2874	330	19	adrp	adrp	PROPN
admet-2874	330	20	)	)	PUNCT
admet-2874	330	21	.	.	PUNCT
admet-2874	331	1	journal	journal	NOUN
admet-2874	331	2	of	of	ADP
admet-2874	331	3	cellular	cellular	ADJ
admet-2874	331	4	physiology	physiology	NOUN
admet-2874	331	5	223	223	NUM
admet-2874	331	6	(	(	PUNCT
admet-2874	331	7	2010	2010	NUM
admet-2874	331	8	)	)	PUNCT
admet-2874	331	9	648657	648657	NUM
admet-2874	331	10	.	.	PUNCT
admet-2874	332	1	https://doi.org/10.1002/jcp.22063	https://doi.org/10.1002/jcp.22063	PROPN
admet-2874	332	2	16	16	NUM
admet-2874	332	3	.	.	PUNCT
admet-2874	333	1	g.	g.	PROPN
admet-2874	333	2	mitropoulou	mitropoulou	PROPN
admet-2874	333	3	,	,	PUNCT
admet-2874	333	4	v.	v.	PROPN
admet-2874	333	5	kompoura	kompoura	PROPN
admet-2874	333	6	,	,	PUNCT
admet-2874	333	7	f.	f.	PROPN
admet-2874	333	8	saffioti	saffioti	PROPN
admet-2874	333	9	,	,	PUNCT
admet-2874	333	10	v.k	v.k	PROPN
admet-2874	333	11	.	.	PROPN
admet-2874	333	12	mavroeidis	mavroeidis	PROPN
admet-2874	333	13	.	.	PUNCT
admet-2874	334	1	the	the	DET
admet-2874	334	2	role	role	NOUN
admet-2874	334	3	of	of	ADP
admet-2874	334	4	matrix	matrix	NOUN
admet-2874	334	5	metalloproteinases	metalloproteinase	NOUN
admet-2874	334	6	in	in	ADP
admet-2874	334	7	liver	liver	NOUN
admet-2874	334	8	function	function	NOUN
admet-2874	334	9	and	and	CCONJ
admet-2874	334	10	disease	disease	NOUN
admet-2874	334	11	.	.	PUNCT
admet-2874	335	1	frontiers	frontier	NOUN
admet-2874	335	2	in	in	ADP
admet-2874	335	3	bioscience	bioscience	PROPN
admet-2874	335	4	(	(	PUNCT
admet-2874	335	5	landmark	landmark	PROPN
admet-2874	335	6	edition	edition	PROPN
admet-2874	335	7	)	)	PUNCT
admet-2874	335	8	30	30	NUM
admet-2874	335	9	(	(	PUNCT
admet-2874	335	10	2025	2025	NUM
admet-2874	335	11	)	)	PUNCT
admet-2874	335	12	27127	27127	NUM
admet-2874	335	13	.	.	PUNCT
admet-2874	336	1	https://doi.org/10.31083/fbl27127	https://doi.org/10.31083/fbl27127	NOUN
admet-2874	336	2	17	17	NUM
admet-2874	336	3	.	.	PUNCT
admet-2874	336	4	m.	m.	NOUN
admet-2874	336	5	sato	sato	PROPN
admet-2874	336	6	,	,	PUNCT
admet-2874	336	7	s.	s.	PROPN
admet-2874	336	8	suzuki	suzuki	PROPN
admet-2874	336	9	,	,	PUNCT
admet-2874	336	10	h.	h.	PROPN
admet-2874	336	11	senoo	senoo	PROPN
admet-2874	336	12	.	.	PUNCT
admet-2874	337	1	hepatic	hepatic	ADJ
admet-2874	337	2	stellate	stellate	ADJ
admet-2874	337	3	cells	cell	NOUN
admet-2874	337	4	:	:	PUNCT
admet-2874	337	5	unique	unique	ADJ
admet-2874	337	6	characteristics	characteristic	NOUN
admet-2874	337	7	in	in	ADP
admet-2874	337	8	cell	cell	NOUN
admet-2874	337	9	biology	biology	NOUN
admet-2874	337	10	and	and	CCONJ
admet-2874	337	11	phenotype	phenotype	NOUN
admet-2874	337	12	.	.	PUNCT
admet-2874	338	1	cells	cell	NOUN
admet-2874	338	2	structure	structure	NOUN
admet-2874	338	3	and	and	CCONJ
admet-2874	338	4	function	function	VERB
admet-2874	338	5	28	28	NUM
admet-2874	338	6	(	(	PUNCT
admet-2874	338	7	2003	2003	NUM
admet-2874	338	8	)	)	PUNCT
admet-2874	338	9	105	105	NUM
admet-2874	338	10	-	-	SYM
admet-2874	338	11	112	112	NUM
admet-2874	338	12	.	.	PUNCT
admet-2874	339	1	https://doi.org/10.1247/csf.28.105	https://doi.org/10.1247/csf.28.105	PROPN
admet-2874	339	2	18	18	NUM
admet-2874	339	3	.	.	PUNCT
admet-2874	339	4	q.	q.	PROPN
admet-2874	339	5	tan	tan	PROPN
admet-2874	339	6	,	,	PUNCT
admet-2874	339	7	d.	d.	PROPN
admet-2874	339	8	xia	xia	PROPN
admet-2874	339	9	,	,	PUNCT
admet-2874	339	10	x.	x.	PROPN
admet-2874	339	11	ying	ying	PROPN
admet-2874	339	12	.	.	PUNCT
admet-2874	339	13	mir-29a	mir-29a	NUM
admet-2874	339	14	in	in	ADP
admet-2874	339	15	exosomes	exosome	NOUN
admet-2874	339	16	from	from	ADP
admet-2874	339	17	bone	bone	NOUN
admet-2874	339	18	marrow	marrow	NOUN
admet-2874	339	19	mesenchymal	mesenchymal	NOUN
admet-2874	339	20	stem	stem	NOUN
admet-2874	339	21	cells	cell	NOUN
admet-2874	339	22	inhibit	inhibit	VERB
admet-2874	339	23	fibrosis	fibrosis	NOUN
admet-2874	339	24	during	during	ADP
admet-2874	339	25	endometrial	endometrial	ADJ
admet-2874	339	26	repair	repair	NOUN
admet-2874	339	27	of	of	ADP
admet-2874	339	28	intrauterine	intrauterine	ADJ
admet-2874	339	29	adhesion	adhesion	NOUN
admet-2874	339	30	.	.	PUNCT
admet-2874	340	1	international	international	ADJ
admet-2874	340	2	journal	journal	NOUN
admet-2874	340	3	of	of	ADP
admet-2874	340	4	stem	stem	NOUN
admet-2874	340	5	cells	cell	NOUN
admet-2874	340	6	13	13	NUM
admet-2874	340	7	(	(	PUNCT
admet-2874	340	8	2020	2020	NUM
admet-2874	340	9	)	)	PUNCT
admet-2874	340	10	414	414	NUM
admet-2874	340	11	-	-	SYM
admet-2874	340	12	423	423	NUM
admet-2874	340	13	.	.	PUNCT
admet-2874	341	1	https://doi.org/10.15283/ijsc20049	https://doi.org/10.15283/ijsc20049	PROPN
admet-2874	341	2	19	19	NUM
admet-2874	341	3	.	.	PUNCT
admet-2874	341	4	r.f	r.f	PROPN
admet-2874	341	5	.	.	PROPN
admet-2874	341	6	schwabe	schwabe	PROPN
admet-2874	341	7	,	,	PUNCT
admet-2874	341	8	d.a	d.a	PROPN
admet-2874	341	9	.	.	PROPN
admet-2874	341	10	brenner	brenner	PROPN
admet-2874	341	11	.	.	PUNCT
admet-2874	342	1	hepatic	hepatic	ADJ
admet-2874	342	2	stellate	stellate	ADJ
admet-2874	342	3	cells	cell	NOUN
admet-2874	342	4	:	:	PUNCT
admet-2874	342	5	balancing	balance	VERB
admet-2874	342	6	homeostasis	homeostasis	NOUN
admet-2874	342	7	,	,	PUNCT
admet-2874	342	8	hepatoprotection	hepatoprotection	NOUN
admet-2874	342	9	and	and	CCONJ
admet-2874	342	10	fibrogenesis	fibrogenesis	VERB
admet-2874	342	11	in	in	ADP
admet-2874	342	12	health	health	NOUN
admet-2874	342	13	and	and	CCONJ
admet-2874	342	14	disease	disease	NOUN
admet-2874	342	15	.	.	PUNCT
admet-2874	343	1	nature	nature	NOUN
admet-2874	343	2	reviews	review	VERB
admet-2874	343	3	gastroenterology	gastroenterology	NOUN
admet-2874	343	4	hepatology	hepatology	NOUN
admet-2874	343	5	22	22	NUM
admet-2874	343	6	(	(	PUNCT
admet-2874	343	7	2025	2025	NUM
admet-2874	343	8	)	)	PUNCT
admet-2874	343	9	481	481	NUM
admet-2874	343	10	-	-	SYM
admet-2874	343	11	499	499	NUM
admet-2874	343	12	.	.	PUNCT
admet-2874	344	1	https://doi.org/10.1038/s41575-025-01068-6	https://doi.org/10.1038/s41575-025-01068-6	NUM
admet-2874	344	2	20	20	NUM
admet-2874	344	3	.	.	PUNCT
admet-2874	345	1	v.q.h	v.q.h	PROPN
admet-2874	345	2	.	.	PUNCT
admet-2874	345	3	trinh	trinh	PROPN
admet-2874	345	4	,	,	PUNCT
admet-2874	345	5	t.f	t.f	PROPN
admet-2874	345	6	.	.	PROPN
admet-2874	345	7	lee	lee	PROPN
admet-2874	345	8	,	,	PUNCT
admet-2874	345	9	s.	s.	PROPN
admet-2874	345	10	lemoinne	lemoinne	PROPN
admet-2874	345	11	,	,	PUNCT
admet-2874	345	12	k.c	k.c	PROPN
admet-2874	345	13	.	.	PROPN
admet-2874	345	14	ray	ray	PROPN
admet-2874	345	15	,	,	PUNCT
admet-2874	345	16	m.d	m.d	PROPN
admet-2874	345	17	.	.	PROPN
admet-2874	345	18	ybanez	ybanez	PROPN
admet-2874	345	19	,	,	PUNCT
admet-2874	345	20	t.	t.	PROPN
admet-2874	345	21	tsuchida	tsuchida	PROPN
admet-2874	345	22	,	,	PUNCT
admet-2874	345	23	j.k	j.k	PROPN
admet-2874	345	24	.	.	PROPN
admet-2874	345	25	carter	carter	PROPN
admet-2874	345	26	,	,	PUNCT
admet-2874	345	27	j.	j.	PROPN
admet-2874	345	28	agudo	agudo	PROPN
admet-2874	345	29	,	,	PUNCT
admet-2874	345	30	b.d	b.d	PROPN
admet-2874	345	31	.	.	PROPN
admet-2874	345	32	brown	brown	PROPN
admet-2874	345	33	,	,	PUNCT
admet-2874	345	34	k.m	k.m	PROPN
admet-2874	345	35	.	.	PROPN
admet-2874	345	36	akat	akat	PROPN
admet-2874	345	37	,	,	PUNCT
admet-2874	345	38	s.l	s.l	PROPN
admet-2874	345	39	.	.	PROPN
admet-2874	345	40	friedman	friedman	PROPN
admet-2874	345	41	,	,	PUNCT
admet-2874	345	42	y.a	y.a	PROPN
admet-2874	345	43	.	.	PROPN
admet-2874	345	44	lee	lee	PROPN
admet-2874	345	45	.	.	PUNCT
admet-2874	346	1	hepatic	hepatic	ADJ
admet-2874	346	2	stellate	stellate	ADJ
admet-2874	346	3	cells	cell	NOUN
admet-2874	346	4	maintain	maintain	VERB
admet-2874	346	5	liver	liver	NOUN
admet-2874	346	6	homeostasis	homeostasis	NOUN
admet-2874	346	7	through	through	ADP
admet-2874	346	8	paracrine	paracrine	NOUN
admet-2874	346	9	neurotrophin-3	neurotrophin-3	PRON
admet-2874	346	10	signaling	signal	VERB
admet-2874	346	11	that	that	PRON
admet-2874	346	12	induces	induce	VERB
admet-2874	346	13	hepatocyte	hepatocyte	NOUN
admet-2874	346	14	proliferation	proliferation	NOUN
admet-2874	346	15	.	.	PUNCT
admet-2874	347	1	science	science	NOUN
admet-2874	347	2	signaling	signal	VERB
admet-2874	347	3	16	16	NUM
admet-2874	347	4	(	(	PUNCT
admet-2874	347	5	2023	2023	NUM
admet-2874	347	6	)	)	PUNCT
admet-2874	347	7	eadf6696	eadf6696	NOUN
admet-2874	347	8	.	.	PUNCT
admet-2874	348	1	https://doi.org/10.1126/scisignal.adf6696	https://doi.org/10.1126/scisignal.adf6696	NOUN
admet-2874	348	2	21	21	NUM
admet-2874	348	3	.	.	PUNCT
admet-2874	348	4	d.	d.	PROPN
admet-2874	348	5	cassiman	cassiman	PROPN
admet-2874	348	6	,	,	PUNCT
admet-2874	348	7	c.	c.	PROPN
admet-2874	348	8	denef	denef	PROPN
admet-2874	348	9	,	,	PUNCT
admet-2874	348	10	v.j	v.j	PROPN
admet-2874	348	11	.	.	PROPN
admet-2874	348	12	desmet	desmet	PROPN
admet-2874	348	13	,	,	PUNCT
admet-2874	348	14	t.	t.	NOUN
admet-2874	348	15	roskams	roskam	NOUN
admet-2874	348	16	.	.	PUNCT
admet-2874	349	1	human	human	ADJ
admet-2874	349	2	and	and	CCONJ
admet-2874	349	3	rat	rat	NOUN
admet-2874	349	4	hepatic	hepatic	ADJ
admet-2874	349	5	stellate	stellate	ADJ
admet-2874	349	6	cells	cell	NOUN
admet-2874	349	7	express	express	VERB
admet-2874	349	8	neurotrophins	neurotrophin	NOUN
admet-2874	349	9	and	and	CCONJ
admet-2874	349	10	neurotrophin	neurotrophin	ADJ
admet-2874	349	11	receptors	receptor	NOUN
admet-2874	349	12	.	.	PUNCT
admet-2874	350	1	hepatology	hepatology	NOUN
admet-2874	350	2	(	(	PUNCT
admet-2874	350	3	baltimore	baltimore	PROPN
admet-2874	350	4	,	,	PUNCT
admet-2874	350	5	md	md	PROPN
admet-2874	350	6	.	.	PROPN
admet-2874	350	7	)	)	PUNCT
admet-2874	350	8	33	33	NUM
admet-2874	350	9	(	(	PUNCT
admet-2874	350	10	2001	2001	NUM
admet-2874	350	11	)	)	PUNCT
admet-2874	350	12	148	148	NUM
admet-2874	350	13	-	-	SYM
admet-2874	350	14	158	158	NUM
admet-2874	350	15	.	.	PUNCT
admet-2874	351	1	https://doi.org/10.1053/jhep.2001.20793	https://doi.org/10.1053/jhep.2001.20793	PROPN
admet-2874	351	2	22	22	NUM
admet-2874	351	3	.	.	PUNCT
admet-2874	352	1	patidar	patidar	PROPN
admet-2874	352	2	,	,	PUNCT
admet-2874	352	3	n.	n.	PROPN
admet-2874	352	4	hirani	hirani	PROPN
admet-2874	352	5	,	,	PUNCT
admet-2874	352	6	s.	s.	PROPN
admet-2874	352	7	bharti	bharti	PROPN
admet-2874	352	8	,	,	PUNCT
admet-2874	352	9	m.s	m.s	PROPN
admet-2874	352	10	.	.	PROPN
admet-2874	352	11	baig	baig	PROPN
admet-2874	352	12	.	.	PUNCT
admet-2874	353	1	key	key	ADJ
admet-2874	353	2	regulators	regulator	NOUN
admet-2874	353	3	of	of	ADP
admet-2874	353	4	hepatic	hepatic	ADJ
admet-2874	353	5	stellate	stellate	ADJ
admet-2874	353	6	cell	cell	NOUN
admet-2874	353	7	activation	activation	NOUN
admet-2874	353	8	in	in	ADP
admet-2874	353	9	alcohol	alcohol	NOUN
admet-2874	353	10	liver	liver	NOUN
admet-2874	353	11	disease	disease	NOUN
admet-2874	353	12	:	:	PUNCT
admet-2874	353	13	a	a	DET
admet-2874	353	14	comprehensive	comprehensive	ADJ
admet-2874	353	15	review	review	NOUN
admet-2874	353	16	.	.	PUNCT
admet-2874	354	1	international	international	ADJ
admet-2874	354	2	immunopharmacology	immunopharmacology	NOUN
admet-2874	354	3	141	141	NUM
admet-2874	354	4	(	(	PUNCT
admet-2874	354	5	2024	2024	NUM
admet-2874	354	6	)	)	PUNCT
admet-2874	354	7	112938	112938	NUM
admet-2874	354	8	.	.	PUNCT
admet-2874	355	1	https://doi.org/10.1016/j.intimp.2024.112938	https://doi.org/10.1016/j.intimp.2024.112938	ADJ
admet-2874	355	2	23	23	NUM
admet-2874	355	3	.	.	PUNCT
admet-2874	356	1	y.	y.	PROPN
admet-2874	356	2	geng	geng	PROPN
admet-2874	356	3	,	,	PUNCT
admet-2874	356	4	r.f	r.f	PROPN
admet-2874	356	5	.	.	PROPN
admet-2874	356	6	schwabe	schwabe	PROPN
admet-2874	356	7	.	.	PUNCT
admet-2874	357	1	hepatic	hepatic	ADJ
admet-2874	357	2	stellate	stellate	ADJ
admet-2874	357	3	cell	cell	NOUN
admet-2874	357	4	heterogeneity	heterogeneity	NOUN
admet-2874	357	5	:	:	PUNCT
admet-2874	357	6	functional	functional	ADJ
admet-2874	357	7	aspects	aspect	NOUN
admet-2874	357	8	and	and	CCONJ
admet-2874	357	9	therapeutic	therapeutic	ADJ
admet-2874	357	10	implications	implication	NOUN
admet-2874	357	11	.	.	PUNCT
admet-2874	358	1	hepatology	hepatology	NOUN
admet-2874	358	2	(	(	PUNCT
admet-2874	358	3	2025	2025	NUM
admet-2874	358	4	)	)	PUNCT
admet-2874	358	5	1386	1386	NUM
admet-2874	358	6	.	.	PUNCT
admet-2874	359	1	https://doi.org/10.1097/hep.0000000000001386	https://doi.org/10.1097/hep.0000000000001386	PROPN
admet-2874	359	2	https://doi.org/10.1177/15353702221092672	https://doi.org/10.1177/15353702221092672	VERB
admet-2874	359	3	https://doi.org/10.1038/s41419-022-05088-x	https://doi.org/10.1038/s41419-022-05088-x	PROPN
admet-2874	359	4	https://doi.org/10.3892/mmr.2016.5099	https://doi.org/10.3892/mmr.2016.5099	PROPN
admet-2874	359	5	https://doi.org/10.1002/jcp.22063	https://doi.org/10.1002/jcp.22063	PROPN
admet-2874	359	6	https://doi.org/10.31083/fbl27127	https://doi.org/10.31083/fbl27127	PROPN
admet-2874	359	7	https://doi.org/10.1247/csf.28.105	https://doi.org/10.1247/csf.28.105	PROPN
admet-2874	359	8	https://doi.org/10.15283/ijsc20049	https://doi.org/10.15283/ijsc20049	PROPN
admet-2874	360	1	https://doi.org/10.1126/scisignal.adf6696	https://doi.org/10.1126/scisignal.adf6696	PROPN
admet-2874	360	2	https://doi.org/10.1053/jhep.2001.20793	https://doi.org/10.1053/jhep.2001.20793	PROPN
admet-2874	360	3	https://doi.org/10.1016/j.intimp.2024.112938	https://doi.org/10.1016/j.intimp.2024.112938	PROPN
admet-2874	360	4	https://doi.org/10.1097/hep.0000000000001386	https://doi.org/10.1097/hep.0000000000001386	VERB
admet-2874	360	5	admet	admet	PROPN
admet-2874	360	6	&	&	CCONJ
admet-2874	360	7	dmpk	dmpk	PROPN
admet-2874	360	8	13(4	13(4	NUM
admet-2874	360	9	)	)	PUNCT
admet-2874	360	10	(	(	PUNCT
admet-2874	360	11	2025	2025	NUM
admet-2874	360	12	)	)	PUNCT
admet-2874	360	13	2874	2874	NUM
admet-2874	360	14	hscs	hsc	NOUN
admet-2874	360	15	in	in	ADP
admet-2874	360	16	liver	liver	NOUN
admet-2874	360	17	fibrosis	fibrosis	NOUN
admet-2874	360	18	:	:	PUNCT
admet-2874	360	19	therapeutic	therapeutic	ADJ
admet-2874	360	20	advances	advance	NOUN
admet-2874	360	21	doi	doi	NOUN
admet-2874	360	22	:	:	PUNCT
admet-2874	360	23	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PROPN
admet-2874	360	24	17	17	NUM
admet-2874	360	25	24	24	NUM
admet-2874	360	26	.	.	PUNCT
admet-2874	361	1	m.j	m.j	PROPN
admet-2874	361	2	.	.	PROPN
admet-2874	361	3	mcconnell	mcconnell	PROPN
admet-2874	361	4	,	,	PUNCT
admet-2874	361	5	e.	e.	PROPN
admet-2874	361	6	kostallari	kostallari	PROPN
admet-2874	361	7	,	,	PUNCT
admet-2874	361	8	s.h	s.h	PROPN
admet-2874	361	9	.	.	PROPN
admet-2874	361	10	ibrahim	ibrahim	PROPN
admet-2874	361	11	,	,	PUNCT
admet-2874	361	12	y.	y.	PROPN
admet-2874	361	13	iwakiri	iwakiri	PROPN
admet-2874	361	14	.	.	PUNCT
admet-2874	362	1	the	the	DET
admet-2874	362	2	evolving	evolve	VERB
admet-2874	362	3	role	role	NOUN
admet-2874	362	4	of	of	ADP
admet-2874	362	5	liver	liver	NOUN
admet-2874	362	6	sinusoidal	sinusoidal	NOUN
admet-2874	362	7	endothelial	endothelial	NOUN
admet-2874	362	8	cells	cell	NOUN
admet-2874	362	9	in	in	ADP
admet-2874	362	10	liver	liver	NOUN
admet-2874	362	11	health	health	NOUN
admet-2874	362	12	and	and	CCONJ
admet-2874	362	13	disease	disease	NOUN
admet-2874	362	14	.	.	PUNCT
admet-2874	363	1	hepatology	hepatology	NOUN
admet-2874	363	2	78	78	NUM
admet-2874	363	3	(	(	PUNCT
admet-2874	363	4	2023	2023	NUM
admet-2874	363	5	)	)	PUNCT
admet-2874	363	6	649	649	NUM
admet-2874	363	7	.	.	PUNCT
admet-2874	364	1	https://doi.org/10.1097/hep.0000000000000207	https://doi.org/10.1097/hep.0000000000000207	VERB
admet-2874	364	2	25	25	NUM
admet-2874	364	3	.	.	PUNCT
admet-2874	365	1	j.	j.	PROPN
admet-2874	365	2	poisson	poisson	PROPN
admet-2874	365	3	,	,	PUNCT
admet-2874	365	4	s.	s.	PROPN
admet-2874	365	5	lemoinne	lemoinne	PROPN
admet-2874	365	6	,	,	PUNCT
admet-2874	365	7	c.	c.	PROPN
admet-2874	365	8	boulanger	boulanger	PROPN
admet-2874	365	9	,	,	PUNCT
admet-2874	365	10	f.	f.	PROPN
admet-2874	365	11	durand	durand	PROPN
admet-2874	365	12	,	,	PUNCT
admet-2874	365	13	r.	r.	PROPN
admet-2874	365	14	moreau	moreau	PROPN
admet-2874	365	15	,	,	PUNCT
admet-2874	365	16	d.	d.	PROPN
admet-2874	365	17	valla	valla	PROPN
admet-2874	365	18	,	,	PUNCT
admet-2874	365	19	&	&	CCONJ
admet-2874	365	20	p.-e	p.-e	PROPN
admet-2874	365	21	.	.	PUNCT
admet-2874	366	1	rautou	rautou	PROPN
admet-2874	366	2	.	.	PUNCT
admet-2874	367	1	liver	liver	NOUN
admet-2874	367	2	sinusoidal	sinusoidal	ADJ
admet-2874	367	3	endothelial	endothelial	ADJ
admet-2874	367	4	cells	cell	NOUN
admet-2874	367	5	:	:	PUNCT
admet-2874	367	6	physiology	physiology	NOUN
admet-2874	367	7	and	and	CCONJ
admet-2874	367	8	role	role	NOUN
admet-2874	367	9	in	in	ADP
admet-2874	367	10	liver	liver	NOUN
admet-2874	367	11	diseases	disease	NOUN
admet-2874	367	12	.	.	PUNCT
admet-2874	368	1	journal	journal	NOUN
admet-2874	368	2	of	of	ADP
admet-2874	368	3	hepatology	hepatology	NOUN
admet-2874	368	4	66	66	NUM
admet-2874	368	5	(	(	PUNCT
admet-2874	368	6	2017	2017	NUM
admet-2874	368	7	)	)	PUNCT
admet-2874	368	8	212	212	NUM
admet-2874	368	9	-	-	SYM
admet-2874	368	10	227	227	NUM
admet-2874	368	11	.	.	PUNCT
admet-2874	369	1	https://doi.org/10.1016/j.jhep.2016.07.009	https://doi.org/10.1016/j.jhep.2016.07.009	PROPN
admet-2874	369	2	26	26	NUM
admet-2874	369	3	.	.	PUNCT
admet-2874	369	4	q.	q.	PROPN
admet-2874	369	5	dai	dai	PROPN
admet-2874	369	6	,	,	PUNCT
admet-2874	369	7	q.	q.	PROPN
admet-2874	369	8	ain	ain	PROPN
admet-2874	369	9	,	,	PUNCT
admet-2874	369	10	n.	n.	PROPN
admet-2874	369	11	seth	seth	PROPN
admet-2874	369	12	,	,	PUNCT
admet-2874	369	13	h.	h.	PROPN
admet-2874	369	14	zhao	zhao	PROPN
admet-2874	369	15	,	,	PUNCT
admet-2874	369	16	m.	m.	NOUN
admet-2874	369	17	rooney	rooney	PROPN
admet-2874	369	18	,	,	PUNCT
admet-2874	369	19	a.	a.	NOUN
admet-2874	369	20	zipprich	zipprich	NOUN
admet-2874	369	21	.	.	PUNCT
admet-2874	370	1	aging	age	VERB
admet-2874	370	2	-	-	PUNCT
admet-2874	370	3	associated	associate	VERB
admet-2874	370	4	liver	liver	NOUN
admet-2874	370	5	sinusoidal	sinusoidal	NOUN
admet-2874	370	6	endothelial	endothelial	NOUN
admet-2874	370	7	cells	cell	NOUN
admet-2874	370	8	dysfunction	dysfunction	NOUN
admet-2874	370	9	aggravates	aggravate	VERB
admet-2874	370	10	the	the	DET
admet-2874	370	11	progression	progression	NOUN
admet-2874	370	12	of	of	ADP
admet-2874	370	13	metabolic	metabolic	NOUN
admet-2874	370	14	dysfunctionassociated	dysfunctionassociate	VERB
admet-2874	370	15	steatotic	steatotic	ADJ
admet-2874	370	16	liver	liver	NOUN
admet-2874	370	17	disease	disease	NOUN
admet-2874	370	18	.	.	PUNCT
admet-2874	371	1	aging	age	VERB
admet-2874	371	2	cell	cell	NOUN
admet-2874	371	3	24	24	NUM
admet-2874	371	4	(	(	PUNCT
admet-2874	371	5	2025	2025	NUM
admet-2874	371	6	)	)	PUNCT
admet-2874	371	7	e14502	e14502	PROPN
admet-2874	371	8	.	.	PUNCT
admet-2874	371	9	https://doi.org/10.1111/acel.14502	https://doi.org/10.1111/acel.14502	PROPN
admet-2874	371	10	27	27	NUM
admet-2874	371	11	.	.	PUNCT
admet-2874	372	1	b.	b.	PROPN
admet-2874	372	2	gao	gao	PROPN
admet-2874	372	3	,	,	PUNCT
admet-2874	372	4	s.	s.	PROPN
admet-2874	372	5	radaeva	radaeva	PROPN
admet-2874	372	6	.	.	PUNCT
admet-2874	373	1	natural	natural	ADJ
admet-2874	373	2	killer	killer	NOUN
admet-2874	373	3	and	and	CCONJ
admet-2874	373	4	natural	natural	ADJ
admet-2874	373	5	killer	killer	NOUN
admet-2874	373	6	t	t	PROPN
admet-2874	373	7	cells	cell	NOUN
admet-2874	373	8	in	in	ADP
admet-2874	373	9	liver	liver	NOUN
admet-2874	373	10	fibrosis	fibrosis	NOUN
admet-2874	373	11	.	.	PUNCT
admet-2874	374	1	biochimica	biochimica	PROPN
admet-2874	374	2	et	et	PROPN
admet-2874	374	3	biophysica	biophysica	PROPN
admet-2874	374	4	acta	acta	PROPN
admet-2874	374	5	1832	1832	NUM
admet-2874	374	6	(	(	PUNCT
admet-2874	374	7	2013	2013	NUM
admet-2874	374	8	)	)	PUNCT
admet-2874	374	9	1061	1061	NUM
admet-2874	374	10	-	-	SYM
admet-2874	374	11	1069	1069	NUM
admet-2874	374	12	.	.	PUNCT
admet-2874	375	1	https://doi.org/10.1016/j.bbadis.2012.09.008	https://doi.org/10.1016/j.bbadis.2012.09.008	NOUN
admet-2874	375	2	28	28	NUM
admet-2874	375	3	.	.	PUNCT
admet-2874	376	1	p.	p.	NOUN
admet-2874	376	2	ramachandran	ramachandran	PROPN
admet-2874	376	3	,	,	PUNCT
admet-2874	376	4	j.p	j.p	PROPN
admet-2874	376	5	.	.	PROPN
admet-2874	376	6	iredale	iredale	PROPN
admet-2874	376	7	.	.	PUNCT
admet-2874	377	1	macrophages	macrophage	NOUN
admet-2874	377	2	:	:	PUNCT
admet-2874	377	3	central	central	ADJ
admet-2874	377	4	regulators	regulator	NOUN
admet-2874	377	5	of	of	ADP
admet-2874	377	6	hepatic	hepatic	ADJ
admet-2874	377	7	fibrogenesis	fibrogenesis	NOUN
admet-2874	377	8	and	and	CCONJ
admet-2874	377	9	fibrosis	fibrosis	NOUN
admet-2874	377	10	resolution	resolution	NOUN
admet-2874	377	11	.	.	PUNCT
admet-2874	378	1	journal	journal	PROPN
admet-2874	378	2	of	of	ADP
admet-2874	378	3	hepatology	hepatology	NOUN
admet-2874	378	4	56	56	NUM
admet-2874	378	5	(	(	PUNCT
admet-2874	378	6	2012	2012	NUM
admet-2874	378	7	)	)	PUNCT
admet-2874	378	8	1417	1417	NUM
admet-2874	378	9	-	-	SYM
admet-2874	378	10	1419	1419	NUM
admet-2874	378	11	.	.	PUNCT
admet-2874	379	1	https://doi.org/10.1016/j.jhep.2011.10.026	https://doi.org/10.1016/j.jhep.2011.10.026	PROPN
admet-2874	379	2	29	29	NUM
admet-2874	379	3	.	.	PUNCT
admet-2874	379	4	a.	a.	PROPN
admet-2874	379	5	canbay	canbay	PROPN
admet-2874	379	6	,	,	PUNCT
admet-2874	379	7	p.	p.	PROPN
admet-2874	379	8	taimr	taimr	PROPN
admet-2874	379	9	,	,	PUNCT
admet-2874	379	10	n.	n.	PROPN
admet-2874	379	11	torok	torok	PROPN
admet-2874	379	12	,	,	PUNCT
admet-2874	379	13	h.	h.	PROPN
admet-2874	379	14	higuchi	higuchi	PROPN
admet-2874	379	15	,	,	PUNCT
admet-2874	379	16	s.	s.	PROPN
admet-2874	379	17	friedman	friedman	PROPN
admet-2874	379	18	,	,	PUNCT
admet-2874	379	19	g.j	g.j	PROPN
admet-2874	379	20	.	.	PROPN
admet-2874	379	21	gores	gore	NOUN
admet-2874	379	22	.	.	PUNCT
admet-2874	380	1	apoptotic	apoptotic	ADJ
admet-2874	380	2	body	body	NOUN
admet-2874	380	3	engulfment	engulfment	NOUN
admet-2874	380	4	by	by	ADP
admet-2874	380	5	a	a	DET
admet-2874	380	6	human	human	ADJ
admet-2874	380	7	stellate	stellate	ADJ
admet-2874	380	8	cell	cell	NOUN
admet-2874	380	9	line	line	NOUN
admet-2874	380	10	is	be	AUX
admet-2874	380	11	profibrogenic	profibrogenic	ADJ
admet-2874	380	12	.	.	PUNCT
admet-2874	381	1	laboratory	laboratory	NOUN
admet-2874	381	2	investigation	investigation	NOUN
admet-2874	381	3	83	83	NUM
admet-2874	381	4	(	(	PUNCT
admet-2874	381	5	2003	2003	NUM
admet-2874	381	6	)	)	PUNCT
admet-2874	381	7	655	655	NUM
admet-2874	381	8	-	-	PUNCT
admet-2874	381	9	663	663	NUM
admet-2874	381	10	.	.	PUNCT
admet-2874	382	1	https://doi.org/10.1097/01.lab.0000069036.63405.5c	https://doi.org/10.1097/01.lab.0000069036.63405.5c	PROPN
admet-2874	382	2	30	30	NUM
admet-2874	382	3	.	.	PUNCT
admet-2874	383	1	n.	n.	PROPN
admet-2874	383	2	nieto	nieto	PROPN
admet-2874	383	3	,	,	PUNCT
admet-2874	383	4	s.l	s.l	PROPN
admet-2874	383	5	.	.	PROPN
admet-2874	383	6	friedman	friedman	PROPN
admet-2874	383	7	,	,	PUNCT
admet-2874	383	8	a.i	a.i	PROPN
admet-2874	383	9	.	.	PROPN
admet-2874	383	10	cederbaum	cederbaum	PROPN
admet-2874	383	11	.	.	PUNCT
admet-2874	384	1	cytochrome	cytochrome	VERB
admet-2874	384	2	p450	p450	NUM
admet-2874	384	3	2e1	2e1	NUM
admet-2874	384	4	-	-	PUNCT
admet-2874	384	5	derived	derive	VERB
admet-2874	384	6	reactive	reactive	ADJ
admet-2874	384	7	oxygen	oxygen	NOUN
admet-2874	384	8	species	specie	NOUN
admet-2874	384	9	mediate	mediate	VERB
admet-2874	384	10	paracrine	paracrine	NOUN
admet-2874	384	11	stimulation	stimulation	NOUN
admet-2874	384	12	of	of	ADP
admet-2874	384	13	collagen	collagen	NOUN
admet-2874	384	14	i	i	PRON
admet-2874	384	15	protein	protein	NOUN
admet-2874	384	16	synthesis	synthesis	NOUN
admet-2874	384	17	by	by	ADP
admet-2874	384	18	hepatic	hepatic	ADJ
admet-2874	384	19	stellate	stellate	ADJ
admet-2874	384	20	cells	cell	NOUN
admet-2874	384	21	.	.	PUNCT
admet-2874	385	1	the	the	DET
admet-2874	385	2	journal	journal	NOUN
admet-2874	385	3	of	of	ADP
admet-2874	385	4	biological	biological	ADJ
admet-2874	385	5	277	277	NUM
admet-2874	385	6	(	(	PUNCT
admet-2874	385	7	2002	2002	NUM
admet-2874	385	8	)	)	PUNCT
admet-2874	385	9	9853	9853	NUM
admet-2874	385	10	-	-	SYM
admet-2874	385	11	9864	9864	NUM
admet-2874	385	12	.	.	PUNCT
admet-2874	386	1	https://doi.org/10.1074/jbc.m110506200	https://doi.org/10.1074/jbc.m110506200	X
admet-2874	386	2	31	31	NUM
admet-2874	386	3	.	.	PUNCT
admet-2874	387	1	h.	h.	PROPN
admet-2874	387	2	tsukamoto	tsukamoto	PROPN
admet-2874	387	3	.	.	PUNCT
admet-2874	388	1	epigenetic	epigenetic	ADJ
admet-2874	388	2	mechanism	mechanism	NOUN
admet-2874	388	3	of	of	ADP
admet-2874	388	4	stellate	stellate	ADJ
admet-2874	388	5	cell	cell	NOUN
admet-2874	388	6	trans	trans	NOUN
admet-2874	388	7	-	-	NOUN
admet-2874	388	8	differentiation	differentiation	NOUN
admet-2874	388	9	.	.	PUNCT
admet-2874	389	1	journal	journal	NOUN
admet-2874	389	2	of	of	ADP
admet-2874	389	3	hepatology	hepatology	NOUN
admet-2874	389	4	46	46	NUM
admet-2874	389	5	(	(	PUNCT
admet-2874	389	6	2007	2007	NUM
admet-2874	389	7	)	)	PUNCT
admet-2874	389	8	352	352	NUM
admet-2874	389	9	-	-	SYM
admet-2874	389	10	353	353	NUM
admet-2874	389	11	.	.	PUNCT
admet-2874	390	1	https://doi.org/10.1016/j.jhep.2006.11.002	https://doi.org/10.1016/j.jhep.2006.11.002	PROPN
admet-2874	390	2	32	32	NUM
admet-2874	390	3	.	.	PUNCT
admet-2874	391	1	n.	n.	NOUN
admet-2874	391	2	tarrats	tarrat	NOUN
admet-2874	391	3	,	,	PUNCT
admet-2874	391	4	a.	a.	NOUN
admet-2874	391	5	moles	mole	NOUN
admet-2874	391	6	,	,	PUNCT
admet-2874	391	7	a.	a.	NOUN
admet-2874	391	8	morales	morale	NOUN
admet-2874	391	9	,	,	PUNCT
admet-2874	391	10	c.	c.	PROPN
admet-2874	391	11	garcía	garcía	NOUN
admet-2874	391	12	-	-	PUNCT
admet-2874	391	13	ruiz	ruiz	NOUN
admet-2874	391	14	,	,	PUNCT
admet-2874	391	15	j.c	j.c	PROPN
admet-2874	391	16	.	.	PROPN
admet-2874	391	17	fernández	fernández	PROPN
admet-2874	391	18	-	-	PUNCT
admet-2874	391	19	checa	checa	PROPN
admet-2874	391	20	,	,	PUNCT
admet-2874	391	21	m.	m.	NOUN
admet-2874	391	22	marí	marí	NOUN
admet-2874	391	23	.	.	PUNCT
admet-2874	392	1	critical	critical	ADJ
admet-2874	392	2	role	role	NOUN
admet-2874	392	3	of	of	ADP
admet-2874	392	4	tumor	tumor	NOUN
admet-2874	392	5	necrosis	necrosis	NOUN
admet-2874	392	6	factor	factor	NOUN
admet-2874	392	7	receptor	receptor	NOUN
admet-2874	392	8	1	1	NUM
admet-2874	392	9	,	,	PUNCT
admet-2874	392	10	but	but	CCONJ
admet-2874	392	11	not	not	PART
admet-2874	392	12	2	2	NUM
admet-2874	392	13	,	,	PUNCT
admet-2874	392	14	in	in	ADP
admet-2874	392	15	hepatic	hepatic	ADJ
admet-2874	392	16	stellate	stellate	ADJ
admet-2874	392	17	cell	cell	NOUN
admet-2874	392	18	proliferation	proliferation	NOUN
admet-2874	392	19	,	,	PUNCT
admet-2874	392	20	extracellular	extracellular	ADJ
admet-2874	392	21	matrix	matrix	NOUN
admet-2874	392	22	remodeling	remodeling	NOUN
admet-2874	392	23	,	,	PUNCT
admet-2874	392	24	and	and	CCONJ
admet-2874	392	25	liver	liver	NOUN
admet-2874	392	26	fibrogenesis	fibrogenesis	NOUN
admet-2874	392	27	.	.	PUNCT
admet-2874	393	1	hepatology	hepatology	NOUN
admet-2874	393	2	(	(	PUNCT
admet-2874	393	3	baltimore	baltimore	PROPN
admet-2874	393	4	,	,	PUNCT
admet-2874	393	5	md	md	PROPN
admet-2874	393	6	.	.	PROPN
admet-2874	393	7	)	)	PUNCT
admet-2874	393	8	54	54	NUM
admet-2874	393	9	(	(	PUNCT
admet-2874	393	10	2011	2011	NUM
admet-2874	393	11	)	)	PUNCT
admet-2874	393	12	319	319	NUM
admet-2874	393	13	-	-	SYM
admet-2874	393	14	327	327	NUM
admet-2874	393	15	.	.	PUNCT
admet-2874	394	1	https://doi.org/10.1002/hep.24388	https://doi.org/10.1002/hep.24388	PROPN
admet-2874	394	2	33	33	NUM
admet-2874	394	3	.	.	PUNCT
admet-2874	395	1	l.	l.	PROPN
admet-2874	395	2	chuliá	chuliá	PROPN
admet-2874	395	3	-	-	PUNCT
admet-2874	395	4	peris	peris	PROPN
admet-2874	395	5	,	,	PUNCT
admet-2874	395	6	c.	c.	PROPN
admet-2874	395	7	carreres	carrere	NOUN
admet-2874	395	8	-	-	PUNCT
admet-2874	395	9	rey	rey	PROPN
admet-2874	395	10	,	,	PUNCT
admet-2874	395	11	m.	m.	NOUN
admet-2874	395	12	gabasa	gabasa	PROPN
admet-2874	395	13	,	,	PUNCT
admet-2874	395	14	j.	j.	PROPN
admet-2874	395	15	alcaraz	alcaraz	PROPN
admet-2874	395	16	,	,	PUNCT
admet-2874	395	17	j.	j.	PROPN
admet-2874	395	18	carretero	carretero	PROPN
admet-2874	395	19	,	,	PUNCT
admet-2874	395	20	j.	j.	PROPN
admet-2874	395	21	pereda	pereda	PROPN
admet-2874	395	22	.	.	PUNCT
admet-2874	395	23	matrix	matrix	NOUN
admet-2874	395	24	metalloproteinases	metalloproteinase	NOUN
admet-2874	395	25	and	and	CCONJ
admet-2874	395	26	their	their	PRON
admet-2874	395	27	inhibitors	inhibitor	NOUN
admet-2874	395	28	in	in	ADP
admet-2874	395	29	pulmonary	pulmonary	ADJ
admet-2874	395	30	fibrosis	fibrosis	NOUN
admet-2874	395	31	:	:	PUNCT
admet-2874	395	32	emmprin	emmprin	PROPN
admet-2874	395	33	/	/	SYM
admet-2874	396	1	cd147	cd147	PROPN
admet-2874	396	2	comes	come	VERB
admet-2874	396	3	into	into	ADP
admet-2874	396	4	play	play	NOUN
admet-2874	396	5	.	.	PUNCT
admet-2874	397	1	international	international	ADJ
admet-2874	397	2	journal	journal	NOUN
admet-2874	397	3	of	of	ADP
admet-2874	397	4	molecular	molecular	ADJ
admet-2874	397	5	sciences	science	NOUN
admet-2874	397	6	23	23	NUM
admet-2874	397	7	(	(	PUNCT
admet-2874	397	8	2022	2022	NUM
admet-2874	397	9	)	)	PUNCT
admet-2874	397	10	6894	6894	NUM
admet-2874	397	11	.	.	PUNCT
admet-2874	398	1	https://doi.org/10.3390/ijms23136894	https://doi.org/10.3390/ijms23136894	PROPN
admet-2874	398	2	34	34	NUM
admet-2874	398	3	.	.	PUNCT
admet-2874	398	4	r.	r.	PROPN
admet-2874	398	5	urtasun	urtasun	PROPN
admet-2874	398	6	,	,	PUNCT
admet-2874	398	7	a.	a.	PROPN
admet-2874	398	8	lopategi	lopategi	PROPN
admet-2874	398	9	,	,	PUNCT
admet-2874	398	10	j.	j.	PROPN
admet-2874	398	11	george	george	PROPN
admet-2874	398	12	,	,	PUNCT
admet-2874	398	13	t.m	t.m	PROPN
admet-2874	398	14	.	.	PROPN
admet-2874	398	15	leung	leung	PROPN
admet-2874	398	16	,	,	PUNCT
admet-2874	398	17	y.	y.	PROPN
admet-2874	398	18	lu	lu	PROPN
admet-2874	398	19	,	,	PUNCT
admet-2874	398	20	x.	x.	PROPN
admet-2874	398	21	wang	wang	PROPN
admet-2874	398	22	,	,	PUNCT
admet-2874	398	23	x.	x.	PROPN
admet-2874	398	24	ge	ge	PROPN
admet-2874	398	25	,	,	PUNCT
admet-2874	398	26	m.i	m.i	PROPN
admet-2874	398	27	.	.	PROPN
admet-2874	398	28	fiel	fiel	PROPN
admet-2874	398	29	,	,	PUNCT
admet-2874	398	30	n.	n.	PROPN
admet-2874	398	31	nieto	nieto	PROPN
admet-2874	398	32	.	.	PUNCT
admet-2874	399	1	osteopontin	osteopontin	PROPN
admet-2874	399	2	,	,	PUNCT
admet-2874	399	3	an	an	DET
admet-2874	399	4	oxidant	oxidant	ADJ
admet-2874	399	5	stress	stress	NOUN
admet-2874	399	6	sensitive	sensitive	ADJ
admet-2874	399	7	cytokine	cytokine	NOUN
admet-2874	399	8	,	,	PUNCT
admet-2874	399	9	up	up	ADP
admet-2874	399	10	-	-	PUNCT
admet-2874	399	11	regulates	regulate	VERB
admet-2874	399	12	collagen	collagen	NOUN
admet-2874	399	13	-	-	PUNCT
admet-2874	399	14	i	i	PROPN
admet-2874	399	15	via	via	ADP
admet-2874	399	16	integrin	integrin	NOUN
admet-2874	399	17	α(v)β(3	α(v)β(3	NOUN
admet-2874	399	18	)	)	PUNCT
admet-2874	399	19	engagement	engagement	NOUN
admet-2874	399	20	and	and	CCONJ
admet-2874	399	21	pi3k	pi3k	NOUN
admet-2874	399	22	/	/	SYM
admet-2874	399	23	pakt	pakt	NOUN
admet-2874	399	24	/	/	SYM
admet-2874	399	25	nfκb	nfκb	NOUN
admet-2874	399	26	signaling	signal	VERB
admet-2874	399	27	.	.	PUNCT
admet-2874	400	1	hepatology	hepatology	NOUN
admet-2874	400	2	(	(	PUNCT
admet-2874	400	3	baltimore	baltimore	PROPN
admet-2874	400	4	,	,	PUNCT
admet-2874	400	5	md	md	PROPN
admet-2874	400	6	.	.	PROPN
admet-2874	400	7	)	)	PUNCT
admet-2874	400	8	55	55	NUM
admet-2874	400	9	(	(	PUNCT
admet-2874	400	10	2012	2012	NUM
admet-2874	400	11	)	)	PUNCT
admet-2874	400	12	594	594	NUM
admet-2874	400	13	-	-	SYM
admet-2874	400	14	608	608	NUM
admet-2874	400	15	.	.	PUNCT
admet-2874	401	1	https://doi.org/10.1002/hep.24701	https://doi.org/10.1002/hep.24701	PROPN
admet-2874	401	2	35	35	NUM
admet-2874	401	3	.	.	PUNCT
admet-2874	402	1	e.	e.	PROPN
admet-2874	402	2	seki	seki	PROPN
admet-2874	402	3	,	,	PUNCT
admet-2874	402	4	s.de	s.de	ADJ
admet-2874	402	5	minicis	minicis	NOUN
admet-2874	402	6	,	,	PUNCT
admet-2874	402	7	g.y	g.y	PROPN
admet-2874	402	8	.	.	PUNCT
admet-2874	402	9	gwak	gwak	PROPN
admet-2874	402	10	,	,	PUNCT
admet-2874	402	11	j.	j.	PROPN
admet-2874	402	12	kluwe	kluwe	PROPN
admet-2874	402	13	,	,	PUNCT
admet-2874	402	14	s.	s.	PROPN
admet-2874	402	15	inokuchi	inokuchi	PROPN
admet-2874	402	16	,	,	PUNCT
admet-2874	402	17	c.a	c.a	PROPN
admet-2874	402	18	.	.	PROPN
admet-2874	402	19	bursill	bursill	PROPN
admet-2874	402	20	,	,	PUNCT
admet-2874	402	21	j.m	j.m	PROPN
admet-2874	402	22	.	.	PROPN
admet-2874	402	23	llovet	llovet	PROPN
admet-2874	402	24	,	,	PUNCT
admet-2874	402	25	d.a	d.a	PROPN
admet-2874	402	26	.	.	PROPN
admet-2874	402	27	brenner	brenner	PROPN
admet-2874	402	28	,	,	PUNCT
admet-2874	402	29	r.f	r.f	PROPN
admet-2874	402	30	.	.	PROPN
admet-2874	402	31	schwabe	schwabe	PROPN
admet-2874	402	32	.	.	PUNCT
admet-2874	403	1	ccr1	ccr1	PROPN
admet-2874	403	2	and	and	CCONJ
admet-2874	403	3	ccr5	ccr5	PROPN
admet-2874	403	4	promote	promote	VERB
admet-2874	403	5	hepatic	hepatic	ADJ
admet-2874	403	6	fibrosis	fibrosis	NOUN
admet-2874	403	7	in	in	ADP
admet-2874	403	8	mice	mouse	NOUN
admet-2874	403	9	.	.	PUNCT
admet-2874	404	1	the	the	DET
admet-2874	404	2	journal	journal	NOUN
admet-2874	404	3	of	of	ADP
admet-2874	404	4	clinical	clinical	ADJ
admet-2874	404	5	investigation	investigation	NOUN
admet-2874	404	6	119	119	NUM
admet-2874	404	7	(	(	PUNCT
admet-2874	404	8	2009	2009	NUM
admet-2874	404	9	)	)	PUNCT
admet-2874	404	10	1858	1858	NUM
admet-2874	404	11	-	-	SYM
admet-2874	404	12	1870	1870	NUM
admet-2874	404	13	.	.	PUNCT
admet-2874	405	1	https://doi.org/10.1172/jci37444	https://doi.org/10.1172/jci37444	NOUN
admet-2874	405	2	36	36	NUM
admet-2874	405	3	.	.	PUNCT
admet-2874	405	4	d.l	d.l	PROPN
admet-2874	405	5	.	.	PROPN
admet-2874	405	6	rebolledo	rebolledo	PROPN
admet-2874	405	7	,	,	PUNCT
admet-2874	405	8	k.e	k.e	PROPN
admet-2874	405	9	.	.	PROPN
admet-2874	405	10	lipson	lipson	PROPN
admet-2874	405	11	,	,	PUNCT
admet-2874	405	12	e.	e.	PROPN
admet-2874	405	13	brandan	brandan	PROPN
admet-2874	405	14	.	.	PUNCT
admet-2874	406	1	driving	drive	VERB
admet-2874	406	2	fibrosis	fibrosis	NOUN
admet-2874	406	3	in	in	ADP
admet-2874	406	4	neuromuscular	neuromuscular	ADJ
admet-2874	406	5	diseases	disease	NOUN
admet-2874	406	6	:	:	PUNCT
admet-2874	406	7	role	role	NOUN
admet-2874	406	8	and	and	CCONJ
admet-2874	406	9	regulation	regulation	NOUN
admet-2874	406	10	of	of	ADP
admet-2874	406	11	connective	connective	ADJ
admet-2874	406	12	tissue	tissue	NOUN
admet-2874	406	13	growth	growth	NOUN
admet-2874	406	14	factor	factor	NOUN
admet-2874	406	15	(	(	PUNCT
admet-2874	406	16	ccn2	ccn2	NOUN
admet-2874	406	17	/	/	SYM
admet-2874	406	18	ctgf	ctgf	NOUN
admet-2874	406	19	)	)	PUNCT
admet-2874	406	20	.	.	PUNCT
admet-2874	407	1	matrix	matrix	NOUN
admet-2874	407	2	biology	biology	NOUN
admet-2874	407	3	plus	plus	CCONJ
admet-2874	407	4	11	11	NUM
admet-2874	407	5	(	(	PUNCT
admet-2874	407	6	2021	2021	NUM
admet-2874	407	7	)	)	PUNCT
admet-2874	407	8	100059	100059	NUM
admet-2874	407	9	.	.	PUNCT
admet-2874	408	1	https://doi.org/10.1016/j.mbplus.2021.100059	https://doi.org/10.1016/j.mbplus.2021.100059	ADJ
admet-2874	408	2	37	37	NUM
admet-2874	408	3	.	.	PUNCT
admet-2874	409	1	j.	j.	PROPN
admet-2874	409	2	wang	wang	PROPN
admet-2874	409	3	,	,	PUNCT
admet-2874	409	4	e.	e.	PROPN
admet-2874	409	5	s.	s.	PROPN
admet-2874	409	6	h.	h.	PROPN
admet-2874	409	7	chu	chu	PROPN
admet-2874	409	8	,	,	PUNCT
admet-2874	409	9	h.-y	h.-y	NOUN
admet-2874	409	10	.	.	PUNCT
admet-2874	410	1	chen	chen	PROPN
admet-2874	410	2	,	,	PUNCT
admet-2874	410	3	k.	k.	PROPN
admet-2874	410	4	man	man	PROPN
admet-2874	410	5	,	,	PUNCT
admet-2874	410	6	m.	m.	PROPN
admet-2874	410	7	y.	y.	PROPN
admet-2874	410	8	y.	y.	PROPN
admet-2874	410	9	go	go	VERB
admet-2874	410	10	,	,	PUNCT
admet-2874	410	11	x.	x.	PROPN
admet-2874	410	12	r.	r.	PROPN
admet-2874	410	13	huang	huang	PROPN
admet-2874	410	14	,	,	PUNCT
admet-2874	410	15	h.	h.	PROPN
admet-2874	410	16	y.	y.	PROPN
admet-2874	410	17	lan	lan	PROPN
admet-2874	410	18	,	,	PUNCT
admet-2874	410	19	j.	j.	PROPN
admet-2874	410	20	j.	j.	PROPN
admet-2874	410	21	y.	y.	PROPN
admet-2874	410	22	sung	sung	PROPN
admet-2874	410	23	,	,	PUNCT
admet-2874	410	24	j.	j.	PROPN
admet-2874	410	25	yu	yu	PROPN
admet-2874	410	26	,	,	PUNCT
admet-2874	410	27	microrna-29b	microrna-29b	NOUN
admet-2874	410	28	prevents	prevent	VERB
admet-2874	410	29	liver	liver	NOUN
admet-2874	410	30	fibrosis	fibrosis	NOUN
admet-2874	410	31	by	by	ADP
admet-2874	410	32	attenuating	attenuate	VERB
admet-2874	410	33	hepatic	hepatic	ADJ
admet-2874	410	34	stellate	stellate	ADJ
admet-2874	410	35	cell	cell	NOUN
admet-2874	410	36	activation	activation	NOUN
admet-2874	410	37	and	and	CCONJ
admet-2874	410	38	inducing	induce	VERB
admet-2874	410	39	apoptosis	apoptosis	NOUN
admet-2874	410	40	through	through	ADP
admet-2874	410	41	targeting	target	VERB
admet-2874	410	42	pi3k	pi3k	PROPN
admet-2874	410	43	/	/	SYM
admet-2874	410	44	akt	akt	PROPN
admet-2874	410	45	pathway	pathway	NOUN
admet-2874	410	46	.	.	PUNCT
admet-2874	411	1	oncotarget	oncotarget	VERB
admet-2874	411	2	6	6	NUM
admet-2874	411	3	(	(	PUNCT
admet-2874	411	4	2015	2015	NUM
admet-2874	411	5	)	)	PUNCT
admet-2874	411	6	7325	7325	NUM
admet-2874	411	7	-	-	SYM
admet-2874	411	8	7338	7338	NUM
admet-2874	411	9	.	.	PUNCT
admet-2874	412	1	https://doi.org/10.18632/oncotarget.2621	https://doi.org/10.18632/oncotarget.2621	PROPN
admet-2874	412	2	38	38	NUM
admet-2874	412	3	.	.	PUNCT
admet-2874	413	1	e.	e.	PROPN
admet-2874	413	2	novo	novo	PROPN
admet-2874	413	3	,	,	PUNCT
admet-2874	413	4	d.	d.	PROPN
admet-2874	413	5	povero	povero	PROPN
admet-2874	413	6	,	,	PUNCT
admet-2874	413	7	c.	c.	PROPN
admet-2874	413	8	busletta	busletta	PROPN
admet-2874	413	9	,	,	PUNCT
admet-2874	413	10	c.	c.	PROPN
admet-2874	413	11	paternostro	paternostro	NOUN
admet-2874	413	12	,	,	PUNCT
admet-2874	413	13	l.v	l.v	PROPN
admet-2874	413	14	.	.	PROPN
admet-2874	413	15	di	di	PROPN
admet-2874	413	16	bonzo	bonzo	PROPN
admet-2874	413	17	,	,	PUNCT
admet-2874	413	18	s.	s.	PROPN
admet-2874	413	19	cannito	cannito	PROPN
admet-2874	413	20	,	,	PUNCT
admet-2874	413	21	a.	a.	NOUN
admet-2874	413	22	compagnone	compagnone	NOUN
admet-2874	413	23	,	,	PUNCT
admet-2874	413	24	a.	a.	NOUN
admet-2874	413	25	bandino	bandino	PROPN
admet-2874	413	26	,	,	PUNCT
admet-2874	413	27	f.	f.	PROPN
admet-2874	413	28	marra	marra	PROPN
admet-2874	413	29	,	,	PUNCT
admet-2874	413	30	s.	s.	PROPN
admet-2874	413	31	colombatto	colombatto	PROPN
admet-2874	413	32	,	,	PUNCT
admet-2874	413	33	e.	e.	PROPN
admet-2874	413	34	david	david	PROPN
admet-2874	413	35	,	,	PUNCT
admet-2874	413	36	m.	m.	NOUN
admet-2874	413	37	pinzani	pinzani	PROPN
admet-2874	413	38	,	,	PUNCT
admet-2874	413	39	m.	m.	NOUN
admet-2874	413	40	parola	parola	PROPN
admet-2874	413	41	.	.	PUNCT
admet-2874	414	1	the	the	DET
admet-2874	414	2	biphasic	biphasic	ADJ
admet-2874	414	3	nature	nature	NOUN
admet-2874	414	4	of	of	ADP
admet-2874	414	5	hypoxia	hypoxia	NOUN
admet-2874	414	6	-	-	PUNCT
admet-2874	414	7	induced	induce	VERB
admet-2874	414	8	directional	directional	ADJ
admet-2874	414	9	migration	migration	NOUN
admet-2874	414	10	of	of	ADP
admet-2874	414	11	activated	activate	VERB
admet-2874	414	12	human	human	ADJ
admet-2874	414	13	hepatic	hepatic	ADJ
admet-2874	414	14	stellate	stellate	ADJ
admet-2874	414	15	cells	cell	NOUN
admet-2874	414	16	.	.	PUNCT
admet-2874	415	1	journal	journal	PROPN
admet-2874	415	2	of	of	ADP
admet-2874	415	3	pathology	pathology	PROPN
admet-2874	415	4	226	226	NUM
admet-2874	415	5	(	(	PUNCT
admet-2874	415	6	2012	2012	NUM
admet-2874	415	7	)	)	PUNCT
admet-2874	415	8	588	588	NUM
admet-2874	415	9	-	-	SYM
admet-2874	415	10	597	597	NUM
admet-2874	415	11	.	.	PUNCT
admet-2874	416	1	https://doi.org/10.1002/path.3005	https://doi.org/10.1002/path.3005	NOUN
admet-2874	416	2	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	416	3	https://doi.org/10.1097/hep.0000000000000207	https://doi.org/10.1097/hep.0000000000000207	VERB
admet-2874	416	4	https://doi.org/10.1016/j.jhep.2016.07.009	https://doi.org/10.1016/j.jhep.2016.07.009	PROPN
admet-2874	416	5	https://doi.org/10.1111/acel.14502	https://doi.org/10.1111/acel.14502	NOUN
admet-2874	416	6	https://doi.org/10.1016/j.bbadis.2012.09.008	https://doi.org/10.1016/j.bbadis.2012.09.008	VERB
admet-2874	416	7	https://doi.org/10.1074/jbc.m110506200	https://doi.org/10.1074/jbc.m110506200	NUM
admet-2874	416	8	https://doi.org/10.1002/hep.24388	https://doi.org/10.1002/hep.24388	PROPN
admet-2874	416	9	https://doi.org/10.3390/ijms23136894	https://doi.org/10.3390/ijms23136894	PROPN
admet-2874	416	10	https://doi.org/10.1002/hep.24701	https://doi.org/10.1002/hep.24701	PROPN
admet-2874	416	11	https://doi.org/10.1172/jci37444	https://doi.org/10.1172/jci37444	PROPN
admet-2874	417	1	https://doi.org/10.18632/oncotarget.2621	https://doi.org/10.18632/oncotarget.2621	PROPN
admet-2874	417	2	https://doi.org/10.1002/path.3005	https://doi.org/10.1002/path.3005	NOUN
admet-2874	417	3	a.	a.	NOUN
admet-2874	417	4	singh	singh	PROPN
admet-2874	417	5	et	et	PROPN
admet-2874	417	6	al	al	PROPN
admet-2874	417	7	.	.	PROPN
admet-2874	417	8	admet	admet	PROPN
admet-2874	417	9	&	&	CCONJ
admet-2874	417	10	dmpk	dmpk	PROPN
admet-2874	417	11	13(4	13(4	NUM
admet-2874	417	12	)	)	PUNCT
admet-2874	417	13	(	(	PUNCT
admet-2874	417	14	2025	2025	NUM
admet-2874	417	15	)	)	PUNCT
admet-2874	417	16	2874	2874	NUM
admet-2874	417	17	18	18	NUM
admet-2874	417	18	39	39	NUM
admet-2874	417	19	.	.	PUNCT
admet-2874	418	1	j.	j.	PROPN
admet-2874	418	2	li	li	PROPN
admet-2874	418	3	,	,	PUNCT
admet-2874	418	4	s.j	s.j	PROPN
admet-2874	418	5	.	.	PROPN
admet-2874	418	6	qiu	qiu	PROPN
admet-2874	418	7	,	,	PUNCT
admet-2874	418	8	w.m	w.m	PROPN
admet-2874	418	9	.	.	PUNCT
admet-2874	419	1	she	she	PRON
admet-2874	419	2	,	,	PUNCT
admet-2874	419	3	f.p	f.p	PROPN
admet-2874	419	4	.	.	PROPN
admet-2874	419	5	wang	wang	PROPN
admet-2874	419	6	,	,	PUNCT
admet-2874	419	7	h.	h.	PROPN
admet-2874	419	8	gao	gao	PROPN
admet-2874	419	9	,	,	PUNCT
admet-2874	419	10	l.	l.	PROPN
admet-2874	419	11	li	li	PROPN
admet-2874	419	12	,	,	PUNCT
admet-2874	419	13	c.t	c.t	PROPN
admet-2874	419	14	.	.	PROPN
admet-2874	419	15	tu	tu	PROPN
admet-2874	419	16	,	,	PUNCT
admet-2874	419	17	j.y	j.y	PROPN
admet-2874	419	18	.	.	PROPN
admet-2874	419	19	wang	wang	PROPN
admet-2874	419	20	,	,	PUNCT
admet-2874	419	21	x.z	x.z	PROPN
admet-2874	419	22	.	.	PROPN
admet-2874	419	23	shen	shen	PROPN
admet-2874	419	24	,	,	PUNCT
admet-2874	419	25	w.	w.	PROPN
admet-2874	419	26	jiang	jiang	PROPN
admet-2874	419	27	.	.	PUNCT
admet-2874	420	1	significance	significance	NOUN
admet-2874	420	2	of	of	ADP
admet-2874	420	3	the	the	DET
admet-2874	420	4	balance	balance	NOUN
admet-2874	420	5	between	between	ADP
admet-2874	420	6	regulatory	regulatory	ADJ
admet-2874	420	7	t	t	PROPN
admet-2874	420	8	(	(	PUNCT
admet-2874	420	9	treg	treg	PROPN
admet-2874	420	10	)	)	PUNCT
admet-2874	420	11	and	and	CCONJ
admet-2874	420	12	t	t	PROPN
admet-2874	420	13	helper	helper	NOUN
admet-2874	420	14	17	17	NUM
admet-2874	420	15	(	(	PUNCT
admet-2874	420	16	th17	th17	NOUN
admet-2874	420	17	)	)	PUNCT
admet-2874	420	18	cells	cell	NOUN
admet-2874	420	19	during	during	ADP
admet-2874	420	20	hepatitis	hepatitis	PROPN
admet-2874	420	21	b	b	PROPN
admet-2874	420	22	virus	virus	NOUN
admet-2874	420	23	related	relate	VERB
admet-2874	420	24	liver	liver	NOUN
admet-2874	420	25	fibrosis	fibrosis	NOUN
admet-2874	420	26	.	.	PUNCT
admet-2874	421	1	plos	plos	PROPN
admet-2874	421	2	one	one	NUM
admet-2874	421	3	7(6	7(6	NUM
admet-2874	421	4	)	)	PUNCT
admet-2874	421	5	(	(	PUNCT
admet-2874	421	6	2012	2012	NUM
admet-2874	421	7	)	)	PUNCT
admet-2874	421	8	e39307	e39307	NOUN
admet-2874	421	9	.	.	PUNCT
admet-2874	422	1	https://doi.org/10.1371/journal.pone.0039307	https://doi.org/10.1371/journal.pone.0039307	NOUN
admet-2874	422	2	40	40	NUM
admet-2874	422	3	.	.	PUNCT
admet-2874	423	1	y.	y.	PROPN
admet-2874	423	2	li	li	PROPN
admet-2874	423	3	,	,	PUNCT
admet-2874	423	4	b.	b.	PROPN
admet-2874	423	5	huang	huang	PROPN
admet-2874	423	6	,	,	PUNCT
admet-2874	423	7	x.	x.	PROPN
admet-2874	423	8	jiang	jiang	PROPN
admet-2874	423	9	,	,	PUNCT
admet-2874	423	10	w.	w.	PROPN
admet-2874	423	11	chen	chen	PROPN
admet-2874	423	12	,	,	PUNCT
admet-2874	423	13	j.	j.	PROPN
admet-2874	423	14	zhang	zhang	PROPN
admet-2874	423	15	,	,	PUNCT
admet-2874	423	16	y.	y.	PROPN
admet-2874	423	17	wei	wei	PROPN
admet-2874	423	18	,	,	PUNCT
admet-2874	423	19	y.	y.	PROPN
admet-2874	423	20	chen	chen	PROPN
admet-2874	423	21	,	,	PUNCT
admet-2874	423	22	m.	m.	PROPN
admet-2874	423	23	lian	lian	PROPN
admet-2874	423	24	,	,	PUNCT
admet-2874	423	25	z.	z.	PROPN
admet-2874	423	26	bian	bian	PROPN
admet-2874	423	27	,	,	PUNCT
admet-2874	423	28	q.	q.	PROPN
admet-2874	423	29	miao	miao	PROPN
admet-2874	423	30	,	,	PUNCT
admet-2874	423	31	y.	y.	PROPN
admet-2874	423	32	peng	peng	PROPN
admet-2874	423	33	,	,	PUNCT
admet-2874	423	34	j.	j.	PROPN
admet-2874	423	35	fang	fang	PROPN
admet-2874	423	36	,	,	PUNCT
admet-2874	423	37	q.	q.	PROPN
admet-2874	423	38	wang	wang	PROPN
admet-2874	423	39	,	,	PUNCT
admet-2874	423	40	r.	r.	PROPN
admet-2874	423	41	tang	tang	PROPN
admet-2874	423	42	,	,	PUNCT
admet-2874	423	43	m.e	m.e	PROPN
admet-2874	423	44	.	.	PROPN
admet-2874	423	45	gershwin	gershwin	PROPN
admet-2874	423	46	,	,	PUNCT
admet-2874	423	47	x.	x.	PROPN
admet-2874	423	48	ma	ma	PROPN
admet-2874	423	49	.	.	PROPN
admet-2874	423	50	mucosal	mucosal	NOUN
admet-2874	423	51	-	-	PUNCT
admet-2874	423	52	associated	associate	VERB
admet-2874	423	53	invariant	invariant	PROPN
admet-2874	423	54	t	t	NOUN
admet-2874	423	55	cells	cell	NOUN
admet-2874	423	56	improve	improve	VERB
admet-2874	423	57	nonalcoholic	nonalcoholic	ADJ
admet-2874	423	58	fatty	fatty	NOUN
admet-2874	423	59	liver	liver	NOUN
admet-2874	423	60	disease	disease	NOUN
admet-2874	423	61	through	through	ADP
admet-2874	423	62	regulating	regulate	VERB
admet-2874	423	63	macrophage	macrophage	ADJ
admet-2874	423	64	polarization	polarization	NOUN
admet-2874	423	65	.	.	PUNCT
admet-2874	424	1	frontiers	frontier	NOUN
admet-2874	424	2	in	in	ADP
admet-2874	424	3	immunology	immunology	NOUN
admet-2874	424	4	9	9	NUM
admet-2874	424	5	(	(	PUNCT
admet-2874	424	6	2018	2018	NUM
admet-2874	424	7	)	)	PUNCT
admet-2874	424	8	1994	1994	NUM
admet-2874	424	9	.	.	PUNCT
admet-2874	425	1	https://doi.org/10.3389/fimmu.2018.01994	https://doi.org/10.3389/fimmu.2018.01994	PROPN
admet-2874	425	2	41	41	NUM
admet-2874	425	3	.	.	PUNCT
admet-2874	426	1	p.	p.	NOUN
admet-2874	426	2	hegde	hegde	PROPN
admet-2874	426	3	,	,	PUNCT
admet-2874	426	4	e.	e.	PROPN
admet-2874	426	5	weiss	weiss	PROPN
admet-2874	426	6	,	,	PUNCT
admet-2874	426	7	v.	v.	PROPN
admet-2874	426	8	paradis	paradis	PROPN
admet-2874	426	9	,	,	PUNCT
admet-2874	426	10	j.	j.	PROPN
admet-2874	426	11	wan	wan	PROPN
admet-2874	426	12	,	,	PUNCT
admet-2874	426	13	m.	m.	NOUN
admet-2874	426	14	mabire	mabire	PROPN
admet-2874	426	15	,	,	PUNCT
admet-2874	426	16	s.	s.	PROPN
admet-2874	426	17	sukriti	sukriti	PROPN
admet-2874	426	18	,	,	PUNCT
admet-2874	426	19	p.e	p.e	PROPN
admet-2874	426	20	.	.	PROPN
admet-2874	426	21	rautou	rautou	PROPN
admet-2874	426	22	,	,	PUNCT
admet-2874	426	23	m.	m.	NOUN
admet-2874	426	24	albuquerque	albuquerque	PROPN
admet-2874	426	25	,	,	PUNCT
admet-2874	426	26	o.	o.	PROPN
admet-2874	426	27	picq	picq	PROPN
admet-2874	426	28	,	,	PUNCT
admet-2874	426	29	a.c	a.c	PROPN
admet-2874	426	30	.	.	PROPN
admet-2874	426	31	gupta	gupta	PROPN
admet-2874	426	32	,	,	PUNCT
admet-2874	426	33	g.	g.	PROPN
admet-2874	426	34	ferrere	ferrere	PROPN
admet-2874	426	35	,	,	PUNCT
admet-2874	426	36	h.	h.	PROPN
admet-2874	426	37	gilgenkrantz	gilgenkrantz	PROPN
admet-2874	426	38	,	,	PUNCT
admet-2874	426	39	b.	b.	PROPN
admet-2874	426	40	kiaf	kiaf	PROPN
admet-2874	426	41	,	,	PUNCT
admet-2874	426	42	a.	a.	NOUN
admet-2874	426	43	toubal	toubal	PROPN
admet-2874	426	44	,	,	PUNCT
admet-2874	426	45	l.	l.	PROPN
admet-2874	426	46	beaudoin	beaudoin	PROPN
admet-2874	426	47	,	,	PUNCT
admet-2874	426	48	p.	p.	NOUN
admet-2874	426	49	lettéron	lettéron	NOUN
admet-2874	426	50	,	,	PUNCT
admet-2874	426	51	r.	r.	PROPN
admet-2874	426	52	moreau	moreau	PROPN
admet-2874	426	53	,	,	PUNCT
admet-2874	426	54	a.	a.	PROPN
admet-2874	426	55	lehuen	lehuen	PROPN
admet-2874	426	56	,	,	PUNCT
admet-2874	426	57	s.	s.	PROPN
admet-2874	426	58	lotersztajn	lotersztajn	PROPN
admet-2874	426	59	.	.	PUNCT
admet-2874	427	1	mucosal	mucosal	NOUN
admet-2874	427	2	-	-	PUNCT
admet-2874	427	3	associated	associate	VERB
admet-2874	427	4	invariant	invariant	PROPN
admet-2874	427	5	t	t	PROPN
admet-2874	427	6	cells	cell	NOUN
admet-2874	427	7	are	be	AUX
admet-2874	427	8	a	a	DET
admet-2874	427	9	profibrogenic	profibrogenic	ADJ
admet-2874	427	10	immune	immune	ADJ
admet-2874	427	11	cell	cell	NOUN
admet-2874	427	12	population	population	NOUN
admet-2874	427	13	in	in	ADP
admet-2874	427	14	the	the	DET
admet-2874	427	15	liver	liver	NOUN
admet-2874	427	16	.	.	PUNCT
admet-2874	428	1	nature	nature	NOUN
admet-2874	428	2	communications	communication	NOUN
admet-2874	428	3	9	9	NUM
admet-2874	428	4	(	(	PUNCT
admet-2874	428	5	2018	2018	NUM
admet-2874	428	6	)	)	PUNCT
admet-2874	428	7	2146	2146	NUM
admet-2874	428	8	.	.	PUNCT
admet-2874	429	1	https://doi.org/10.1038/s41467-018-04450-y	https://doi.org/10.1038/s41467-018-04450-y	PROPN
admet-2874	429	2	42	42	NUM
admet-2874	429	3	.	.	PUNCT
admet-2874	430	1	m.	m.	PROPN
admet-2874	430	2	liu	liu	PROPN
admet-2874	430	3	,	,	PUNCT
admet-2874	430	4	y.	y.	PROPN
admet-2874	430	5	hu	hu	PROPN
admet-2874	430	6	,	,	PUNCT
admet-2874	430	7	y.	y.	PROPN
admet-2874	430	8	yuan	yuan	PROPN
admet-2874	430	9	,	,	PUNCT
admet-2874	430	10	z.	z.	PROPN
admet-2874	430	11	tian	tian	PROPN
admet-2874	430	12	,	,	PUNCT
admet-2874	430	13	c.	c.	PROPN
admet-2874	430	14	zhang	zhang	PROPN
admet-2874	430	15	.	.	PROPN
admet-2874	431	1	γδt	γδt	PROPN
admet-2874	431	2	cells	cell	NOUN
admet-2874	431	3	suppress	suppress	VERB
admet-2874	431	4	liver	liver	NOUN
admet-2874	431	5	fibrosis	fibrosis	NOUN
admet-2874	431	6	via	via	ADP
admet-2874	431	7	strong	strong	ADJ
admet-2874	431	8	cytolysis	cytolysis	NOUN
admet-2874	431	9	and	and	CCONJ
admet-2874	431	10	enhanced	enhance	VERB
admet-2874	431	11	nk	nk	PROPN
admet-2874	431	12	cell	cell	NOUN
admet-2874	431	13	-	-	PUNCT
admet-2874	431	14	mediated	mediate	VERB
admet-2874	431	15	cytotoxicity	cytotoxicity	NOUN
admet-2874	431	16	against	against	ADP
admet-2874	431	17	hepatic	hepatic	ADJ
admet-2874	431	18	stellate	stellate	ADJ
admet-2874	431	19	cells	cell	NOUN
admet-2874	431	20	.	.	PUNCT
admet-2874	432	1	frontiers	frontier	NOUN
admet-2874	432	2	in	in	ADP
admet-2874	432	3	immunology	immunology	NOUN
admet-2874	432	4	10	10	NUM
admet-2874	432	5	(	(	PUNCT
admet-2874	432	6	2019	2019	NUM
admet-2874	432	7	)	)	PUNCT
admet-2874	432	8	477	477	NUM
admet-2874	432	9	.	.	PUNCT
admet-2874	433	1	https://doi.org/10.3389/fimmu.2019.00477	https://doi.org/10.3389/fimmu.2019.00477	PROPN
admet-2874	433	2	43	43	NUM
admet-2874	433	3	.	.	PUNCT
admet-2874	434	1	w.	w.	PROPN
admet-2874	434	2	seo	seo	PROPN
admet-2874	434	3	,	,	PUNCT
admet-2874	434	4	h.s	h.s	PROPN
admet-2874	434	5	.	.	PROPN
admet-2874	434	6	eun	eun	PROPN
admet-2874	434	7	,	,	PUNCT
admet-2874	434	8	s.y	s.y	PROPN
admet-2874	434	9	.	.	PROPN
admet-2874	435	1	kim	kim	PROPN
admet-2874	435	2	,	,	PUNCT
admet-2874	435	3	h.s	h.s	PROPN
admet-2874	435	4	.	.	PROPN
admet-2874	435	5	yi	yi	PROPN
admet-2874	435	6	,	,	PUNCT
admet-2874	435	7	y.s	y.s	PROPN
admet-2874	435	8	.	.	PROPN
admet-2874	435	9	lee	lee	PROPN
admet-2874	435	10	,	,	PUNCT
admet-2874	435	11	s.h	s.h	PROPN
admet-2874	435	12	.	.	PROPN
admet-2874	435	13	park	park	PROPN
admet-2874	435	14	,	,	PUNCT
admet-2874	435	15	m.j	m.j	PROPN
admet-2874	435	16	.	.	PROPN
admet-2874	435	17	jang	jang	PROPN
admet-2874	435	18	,	,	PUNCT
admet-2874	435	19	e.	e.	PROPN
admet-2874	435	20	jo	jo	PROPN
admet-2874	435	21	,	,	PUNCT
admet-2874	435	22	s.c	s.c	PROPN
admet-2874	435	23	.	.	PROPN
admet-2874	435	24	kim	kim	PROPN
admet-2874	435	25	,	,	PUNCT
admet-2874	435	26	y.m	y.m	PROPN
admet-2874	435	27	.	.	PROPN
admet-2874	435	28	han	han	PROPN
admet-2874	435	29	,	,	PUNCT
admet-2874	435	30	k.g	k.g	PROPN
admet-2874	435	31	.	.	PROPN
admet-2874	435	32	park	park	PROPN
admet-2874	435	33	,	,	PUNCT
admet-2874	435	34	w.i	w.i	PROPN
admet-2874	435	35	.	.	PROPN
admet-2874	435	36	jeong	jeong	PROPN
admet-2874	435	37	.	.	PUNCT
admet-2874	436	1	exosome	exosome	PROPN
admet-2874	436	2	-	-	PUNCT
admet-2874	436	3	mediated	mediate	VERB
admet-2874	436	4	activation	activation	NOUN
admet-2874	436	5	of	of	ADP
admet-2874	436	6	toll	toll	NOUN
admet-2874	436	7	-	-	PUNCT
admet-2874	436	8	like	like	ADJ
admet-2874	436	9	receptor	receptor	NOUN
admet-2874	436	10	3	3	NUM
admet-2874	436	11	in	in	ADP
admet-2874	436	12	stellate	stellate	ADJ
admet-2874	436	13	cells	cell	NOUN
admet-2874	436	14	stimulates	stimulate	VERB
admet-2874	436	15	interleukin-17	interleukin-17	DET
admet-2874	436	16	production	production	NOUN
admet-2874	436	17	by	by	ADP
admet-2874	436	18	γδ	γδ	ADP
admet-2874	436	19	t	t	PROPN
admet-2874	436	20	cells	cell	NOUN
admet-2874	436	21	in	in	ADP
admet-2874	436	22	liver	liver	NOUN
admet-2874	436	23	fibrosis	fibrosis	NOUN
admet-2874	436	24	.	.	PUNCT
admet-2874	437	1	hepatology	hepatology	NOUN
admet-2874	437	2	(	(	PUNCT
admet-2874	437	3	baltimore	baltimore	PROPN
admet-2874	437	4	,	,	PUNCT
admet-2874	437	5	md	md	PROPN
admet-2874	437	6	.	.	PROPN
admet-2874	437	7	)	)	PUNCT
admet-2874	437	8	64	64	NUM
admet-2874	437	9	(	(	PUNCT
admet-2874	437	10	2016	2016	NUM
admet-2874	437	11	)	)	PUNCT
admet-2874	437	12	616	616	NUM
admet-2874	437	13	-	-	SYM
admet-2874	437	14	631	631	NUM
admet-2874	437	15	.	.	PUNCT
admet-2874	438	1	https://doi.org/10.1002/hep.28644	https://doi.org/10.1002/hep.28644	PROPN
admet-2874	438	2	44	44	NUM
admet-2874	438	3	.	.	PUNCT
admet-2874	439	1	h.	h.	PROPN
admet-2874	439	2	gilgenkrantz	gilgenkrantz	PROPN
admet-2874	439	3	,	,	PUNCT
admet-2874	439	4	r.a	r.a	PROPN
admet-2874	439	5	.	.	PROPN
admet-2874	439	6	sayegh	sayegh	PROPN
admet-2874	439	7	,	,	PUNCT
admet-2874	439	8	s.	s.	PROPN
admet-2874	439	9	lotersztajn	lotersztajn	PROPN
admet-2874	439	10	.	.	PUNCT
admet-2874	440	1	immunoregulation	immunoregulation	NOUN
admet-2874	440	2	of	of	ADP
admet-2874	440	3	liver	liver	NOUN
admet-2874	440	4	fibrosis	fibrosis	NOUN
admet-2874	440	5	:	:	PUNCT
admet-2874	440	6	new	new	ADJ
admet-2874	440	7	opportunities	opportunity	NOUN
admet-2874	440	8	for	for	ADP
admet-2874	440	9	antifibrotic	antifibrotic	ADJ
admet-2874	440	10	therapy	therapy	NOUN
admet-2874	440	11	.	.	PUNCT
admet-2874	441	1	annual	annual	ADJ
admet-2874	441	2	review	review	NOUN
admet-2874	441	3	of	of	ADP
admet-2874	441	4	pharmacology	pharmacology	NOUN
admet-2874	441	5	and	and	CCONJ
admet-2874	441	6	toxicology	toxicology	NOUN
admet-2874	441	7	65	65	NUM
admet-2874	441	8	(	(	PUNCT
admet-2874	441	9	2025	2025	NUM
admet-2874	441	10	)	)	PUNCT
admet-2874	441	11	281	281	NUM
admet-2874	441	12	-	-	SYM
admet-2874	441	13	299	299	NUM
admet-2874	441	14	.	.	PUNCT
admet-2874	442	1	https://doi.org/10.1146/annurev-pharmtox-020524-012013	https://doi.org/10.1146/annurev-pharmtox-020524-012013	PROPN
admet-2874	442	2	45	45	NUM
admet-2874	442	3	.	.	PUNCT
admet-2874	443	1	r.s	r.s	PROPN
admet-2874	443	2	.	.	PROPN
admet-2874	443	3	wijaya	wijaya	PROPN
admet-2874	443	4	,	,	PUNCT
admet-2874	443	5	s.a	s.a	PROPN
admet-2874	443	6	.	.	PROPN
admet-2874	443	7	read	read	PROPN
admet-2874	443	8	,	,	PUNCT
admet-2874	443	9	s.	s.	PROPN
admet-2874	443	10	schibeci	schibeci	PROPN
admet-2874	443	11	,	,	PUNCT
admet-2874	443	12	m.	m.	NOUN
admet-2874	443	13	eslam	eslam	PROPN
admet-2874	443	14	,	,	PUNCT
admet-2874	443	15	m.k	m.k	PROPN
admet-2874	443	16	.	.	PROPN
admet-2874	443	17	azardaryany	azardaryany	PROPN
admet-2874	443	18	,	,	PUNCT
admet-2874	443	19	k.	k.	PROPN
admet-2874	443	20	el	el	PROPN
admet-2874	443	21	-	-	PROPN
admet-2874	443	22	khobar	khobar	PROPN
admet-2874	443	23	,	,	PUNCT
admet-2874	443	24	d.	d.	PROPN
admet-2874	443	25	van	van	PROPN
admet-2874	443	26	der	der	PROPN
admet-2874	443	27	poorten	poorten	VERB
admet-2874	443	28	,	,	PUNCT
admet-2874	443	29	r.	r.	PROPN
admet-2874	443	30	lin	lin	PROPN
admet-2874	443	31	,	,	PUNCT
admet-2874	443	32	l.	l.	PROPN
admet-2874	443	33	yuen	yuen	PROPN
admet-2874	443	34	,	,	PUNCT
admet-2874	443	35	v.	v.	PROPN
admet-2874	443	36	lam	lam	PROPN
admet-2874	443	37	,	,	PUNCT
admet-2874	443	38	j.	j.	PROPN
admet-2874	443	39	george	george	PROPN
admet-2874	443	40	,	,	PUNCT
admet-2874	443	41	m.w	m.w	PROPN
admet-2874	443	42	.	.	PROPN
admet-2874	443	43	douglas	douglas	PROPN
admet-2874	443	44	,	,	PUNCT
admet-2874	443	45	g.	g.	PROPN
admet-2874	443	46	ahlenstiel	ahlenstiel	PROPN
admet-2874	443	47	.	.	PUNCT
admet-2874	444	1	klrg1	klrg1	PROPN
admet-2874	444	2	+	+	SYM
admet-2874	444	3	natural	natural	ADJ
admet-2874	444	4	killer	killer	NOUN
admet-2874	444	5	cells	cell	NOUN
admet-2874	444	6	exert	exert	VERB
admet-2874	444	7	a	a	DET
admet-2874	444	8	novel	novel	ADJ
admet-2874	444	9	antifibrotic	antifibrotic	ADJ
admet-2874	444	10	function	function	NOUN
admet-2874	444	11	in	in	ADP
admet-2874	444	12	chronic	chronic	ADJ
admet-2874	444	13	hepatitis	hepatitis	PROPN
admet-2874	444	14	b.	b.	PROPN
admet-2874	444	15	journal	journal	PROPN
admet-2874	444	16	of	of	ADP
admet-2874	444	17	hepatology	hepatology	NOUN
admet-2874	444	18	71	71	NUM
admet-2874	444	19	(	(	PUNCT
admet-2874	444	20	2019	2019	NUM
admet-2874	444	21	)	)	PUNCT
admet-2874	444	22	252	252	NUM
admet-2874	444	23	-	-	SYM
admet-2874	444	24	264	264	NUM
admet-2874	444	25	.	.	PUNCT
admet-2874	445	1	https://doi.org/10.1016/j.jhep.2019.03.012	https://doi.org/10.1016/j.jhep.2019.03.012	NUM
admet-2874	445	2	46	46	NUM
admet-2874	445	3	.	.	PUNCT
admet-2874	446	1	a.	a.	PROPN
admet-2874	446	2	sugimoto	sugimoto	PROPN
admet-2874	446	3	,	,	PUNCT
admet-2874	446	4	y.	y.	PROPN
admet-2874	446	5	saito	saito	PROPN
admet-2874	446	6	,	,	PUNCT
admet-2874	446	7	g.	g.	PROPN
admet-2874	446	8	wang	wang	PROPN
admet-2874	446	9	,	,	PUNCT
admet-2874	446	10	q.	q.	PROPN
admet-2874	446	11	sun	sun	PROPN
admet-2874	446	12	,	,	PUNCT
admet-2874	446	13	c.	c.	PROPN
admet-2874	446	14	yin	yin	PROPN
admet-2874	446	15	,	,	PUNCT
admet-2874	446	16	k.h	k.h	PROPN
admet-2874	446	17	.	.	PROPN
admet-2874	446	18	lee	lee	PROPN
admet-2874	446	19	,	,	PUNCT
admet-2874	446	20	y.	y.	PROPN
admet-2874	446	21	geng	geng	PROPN
admet-2874	446	22	,	,	PUNCT
admet-2874	446	23	p.	p.	PROPN
admet-2874	446	24	rajbhandari	rajbhandari	PROPN
admet-2874	446	25	,	,	PUNCT
admet-2874	446	26	c.	c.	PROPN
admet-2874	446	27	hernandez	hernandez	PROPN
admet-2874	446	28	,	,	PUNCT
admet-2874	446	29	m.	m.	NOUN
admet-2874	446	30	steffani	steffani	PROPN
admet-2874	446	31	,	,	PUNCT
admet-2874	446	32	j.	j.	PROPN
admet-2874	446	33	qie	qie	PROPN
admet-2874	446	34	,	,	PUNCT
admet-2874	446	35	t.	t.	NOUN
admet-2874	446	36	savage	savage	NOUN
admet-2874	446	37	,	,	PUNCT
admet-2874	446	38	d.m	d.m	PROPN
admet-2874	446	39	.	.	PUNCT
admet-2874	446	40	goyal	goyal	PROPN
admet-2874	446	41	,	,	PUNCT
admet-2874	446	42	k.c	k.c	PROPN
admet-2874	446	43	.	.	PROPN
admet-2874	446	44	ray	ray	PROPN
admet-2874	446	45	,	,	PUNCT
admet-2874	446	46	t.v	t.v	PROPN
admet-2874	446	47	.	.	PROPN
admet-2874	446	48	neelakantan	neelakantan	PROPN
admet-2874	446	49	,	,	PUNCT
admet-2874	446	50	d.	d.	PROPN
admet-2874	446	51	yin	yin	PROPN
admet-2874	446	52	,	,	PUNCT
admet-2874	446	53	j.	j.	PROPN
admet-2874	446	54	melms	melms	PROPN
admet-2874	446	55	,	,	PUNCT
admet-2874	446	56	b.m	b.m	PROPN
admet-2874	446	57	.	.	PROPN
admet-2874	446	58	lehrich	lehrich	PROPN
admet-2874	446	59	,	,	PUNCT
admet-2874	446	60	t.m	t.m	PROPN
admet-2874	446	61	.	.	PROPN
admet-2874	446	62	yasaka	yasaka	PROPN
admet-2874	446	63	,	,	PUNCT
admet-2874	446	64	s.	s.	PROPN
admet-2874	446	65	liu	liu	PROPN
admet-2874	446	66	,	,	PUNCT
admet-2874	446	67	m.	m.	NOUN
admet-2874	446	68	oertel	oertel	NOUN
admet-2874	446	69	,	,	PUNCT
admet-2874	446	70	t.	t.	PROPN
admet-2874	446	71	lan	lan	PROPN
admet-2874	446	72	,	,	PUNCT
admet-2874	446	73	a.	a.	NOUN
admet-2874	446	74	guillot	guillot	NOUN
admet-2874	446	75	,	,	PUNCT
admet-2874	446	76	m.	m.	NOUN
admet-2874	446	77	peiseler	peiseler	PROPN
admet-2874	446	78	,	,	PUNCT
admet-2874	446	79	a.	a.	PROPN
admet-2874	446	80	filliol	filliol	PROPN
admet-2874	446	81	,	,	PUNCT
admet-2874	446	82	h.	h.	PROPN
admet-2874	446	83	kanzaki	kanzaki	PROPN
admet-2874	446	84	,	,	PUNCT
admet-2874	446	85	n.	n.	PROPN
admet-2874	446	86	fujiwara	fujiwara	PROPN
admet-2874	446	87	,	,	PUNCT
admet-2874	446	88	s.	s.	PROPN
admet-2874	446	89	ravi	ravi	PROPN
admet-2874	446	90	,	,	PUNCT
admet-2874	446	91	b.	b.	PROPN
admet-2874	446	92	izar	izar	PROPN
admet-2874	446	93	,	,	PUNCT
admet-2874	446	94	m.	m.	NOUN
admet-2874	446	95	brosch	brosch	PROPN
admet-2874	446	96	,	,	PUNCT
admet-2874	446	97	j.	j.	PROPN
admet-2874	446	98	hampe	hampe	PROPN
admet-2874	446	99	,	,	PUNCT
admet-2874	446	100	h.	h.	PROPN
admet-2874	446	101	remotti	remotti	PROPN
admet-2874	446	102	,	,	PUNCT
admet-2874	446	103	j.	j.	PROPN
admet-2874	446	104	argemi	argemi	PROPN
admet-2874	446	105	,	,	PUNCT
admet-2874	446	106	z.	z.	PROPN
admet-2874	446	107	sun	sun	PROPN
admet-2874	446	108	,	,	PUNCT
admet-2874	446	109	t.j	t.j	PROPN
admet-2874	446	110	.	.	PROPN
admet-2874	446	111	kendall	kendall	PROPN
admet-2874	446	112	,	,	PUNCT
admet-2874	446	113	y.	y.	PROPN
admet-2874	446	114	hoshida	hoshida	PROPN
admet-2874	446	115	,	,	PUNCT
admet-2874	446	116	f.	f.	PROPN
admet-2874	446	117	tacke	tacke	PROPN
admet-2874	446	118	,	,	PUNCT
admet-2874	446	119	j.a	j.a	PROPN
admet-2874	446	120	.	.	PROPN
admet-2874	446	121	fallowfield	fallowfield	PROPN
admet-2874	446	122	,	,	PUNCT
admet-2874	446	123	s.k	s.k	PROPN
admet-2874	446	124	.	.	PROPN
admet-2874	446	125	blockley	blockley	NOUN
admet-2874	446	126	-	-	PUNCT
admet-2874	446	127	powell	powell	PROPN
admet-2874	446	128	,	,	PUNCT
admet-2874	446	129	r.a	r.a	PROPN
admet-2874	446	130	.	.	PROPN
admet-2874	446	131	haeusler	haeusler	PROPN
admet-2874	446	132	,	,	PUNCT
admet-2874	447	1	j.b	j.b	PROPN
admet-2874	447	2	.	.	PROPN
admet-2874	447	3	steinman	steinman	PROPN
admet-2874	447	4	,	,	PUNCT
admet-2874	447	5	u.b	u.b	PROPN
admet-2874	447	6	.	.	PROPN
admet-2874	447	7	pajvani	pajvani	PROPN
admet-2874	447	8	,	,	PUNCT
admet-2874	447	9	s.p	s.p	PROPN
admet-2874	447	10	.	.	PROPN
admet-2874	447	11	monga	monga	PROPN
admet-2874	447	12	,	,	PUNCT
admet-2874	447	13	r.	r.	PROPN
admet-2874	447	14	bataller	bataller	PROPN
admet-2874	447	15	,	,	PUNCT
admet-2874	447	16	m.	m.	NOUN
admet-2874	447	17	masoodi	masoodi	PROPN
admet-2874	447	18	,	,	PUNCT
admet-2874	447	19	n.	n.	PROPN
admet-2874	447	20	arpaia	arpaia	PROPN
admet-2874	447	21	,	,	PUNCT
admet-2874	447	22	y.a	y.a	PROPN
admet-2874	447	23	.	.	PROPN
admet-2874	447	24	lee	lee	PROPN
admet-2874	447	25	,	,	PUNCT
admet-2874	447	26	b.r	b.r	PROPN
admet-2874	447	27	.	.	PROPN
admet-2874	447	28	stockwell	stockwell	PROPN
admet-2874	447	29	,	,	PUNCT
admet-2874	447	30	h.g	h.g	PROPN
admet-2874	447	31	.	.	PROPN
admet-2874	447	32	augustin	augustin	PROPN
admet-2874	447	33	,	,	PUNCT
admet-2874	447	34	r.f	r.f	PROPN
admet-2874	447	35	.	.	PROPN
admet-2874	447	36	schwabe	schwabe	PROPN
admet-2874	447	37	.	.	PUNCT
admet-2874	448	1	hepatic	hepatic	ADJ
admet-2874	448	2	stellate	stellate	ADJ
admet-2874	448	3	cells	cell	NOUN
admet-2874	448	4	control	control	VERB
admet-2874	448	5	liver	liver	NOUN
admet-2874	448	6	zonation	zonation	NOUN
admet-2874	448	7	,	,	PUNCT
admet-2874	448	8	size	size	NOUN
admet-2874	448	9	and	and	CCONJ
admet-2874	448	10	functions	function	NOUN
admet-2874	448	11	via	via	ADP
admet-2874	448	12	r	r	NOUN
admet-2874	448	13	-	-	PUNCT
admet-2874	448	14	spondin	spondin	NOUN
admet-2874	448	15	3	3	NUM
admet-2874	448	16	.	.	X
admet-2874	448	17	nature	nature	NOUN
admet-2874	448	18	640	640	NUM
admet-2874	448	19	(	(	PUNCT
admet-2874	448	20	2025	2025	NUM
admet-2874	448	21	)	)	PUNCT
admet-2874	448	22	752	752	NUM
admet-2874	448	23	-	-	SYM
admet-2874	448	24	761	761	NUM
admet-2874	448	25	.	.	PUNCT
admet-2874	449	1	https://doi.org/10.1038/s41586-025-08677-w	https://doi.org/10.1038/s41586-025-08677-w	NOUN
admet-2874	449	2	47	47	NUM
admet-2874	449	3	.	.	PUNCT
admet-2874	450	1	v.	v.	ADP
admet-2874	450	2	merens	merens	PROPN
admet-2874	450	3	,	,	PUNCT
admet-2874	450	4	e.	e.	PROPN
admet-2874	450	5	knetemann	knetemann	PROPN
admet-2874	450	6	,	,	PUNCT
admet-2874	450	7	e.	e.	PROPN
admet-2874	450	8	gürbüz	gürbüz	PROPN
admet-2874	450	9	,	,	PUNCT
admet-2874	450	10	v.	v.	PROPN
admet-2874	450	11	de	de	PROPN
admet-2874	450	12	smet	smet	PROPN
admet-2874	450	13	,	,	PUNCT
admet-2874	450	14	n.	n.	PROPN
admet-2874	450	15	messaoudi	messaoudi	PROPN
admet-2874	450	16	,	,	PUNCT
admet-2874	450	17	h.	h.	PROPN
admet-2874	450	18	reynaert	reynaert	PROPN
admet-2874	450	19	,	,	PUNCT
admet-2874	450	20	s.	s.	PROPN
admet-2874	450	21	verhulst	verhulst	PROPN
admet-2874	450	22	,	,	PUNCT
admet-2874	450	23	l.	l.	PROPN
admet-2874	450	24	a.	a.	PROPN
admet-2874	450	25	van	van	PROPN
admet-2874	450	26	grunsven	grunsven	VERB
admet-2874	450	27	.	.	PUNCT
admet-2874	451	1	hepatic	hepatic	ADJ
admet-2874	451	2	stellate	stellate	ADJ
admet-2874	451	3	cell	cell	NOUN
admet-2874	451	4	single	single	ADJ
admet-2874	451	5	cell	cell	NOUN
admet-2874	451	6	atlas	atlas	PROPN
admet-2874	451	7	reveals	reveal	VERB
admet-2874	451	8	a	a	DET
admet-2874	451	9	highly	highly	ADV
admet-2874	451	10	similar	similar	ADJ
admet-2874	451	11	activation	activation	NOUN
admet-2874	451	12	process	process	NOUN
admet-2874	451	13	across	across	ADP
admet-2874	451	14	liver	liver	NOUN
admet-2874	451	15	disease	disease	NOUN
admet-2874	451	16	aetiologies	aetiology	NOUN
admet-2874	451	17	.	.	PUNCT
admet-2874	452	1	jhep	jhep	ADJ
admet-2874	452	2	reports	report	NOUN
admet-2874	452	3	7	7	NUM
admet-2874	452	4	(	(	PUNCT
admet-2874	452	5	2025	2025	NUM
admet-2874	452	6	)	)	PUNCT
admet-2874	452	7	101223	101223	NUM
admet-2874	452	8	.	.	PUNCT
admet-2874	453	1	https://doi.org/10.1016/j.jhepr.2024.101223	https://doi.org/10.1016/j.jhepr.2024.101223	NOUN
admet-2874	453	2	48	48	NUM
admet-2874	453	3	.	.	PUNCT
admet-2874	454	1	x.	x.	PROPN
admet-2874	454	2	jiang	jiang	PROPN
admet-2874	454	3	,	,	PUNCT
admet-2874	454	4	w.	w.	PROPN
admet-2874	454	5	zhao	zhao	PROPN
admet-2874	454	6	,	,	PUNCT
admet-2874	454	7	b.	b.	PROPN
admet-2874	454	8	shen	shen	PROPN
admet-2874	454	9	,	,	PUNCT
admet-2874	454	10	y.	y.	PROPN
admet-2874	454	11	han	han	PROPN
admet-2874	454	12	,	,	PUNCT
admet-2874	454	13	k.	k.	PROPN
admet-2874	454	14	chen	chen	PROPN
admet-2874	454	15	.	.	PUNCT
admet-2874	455	1	cd47	cd47	PROPN
admet-2874	455	2	-	-	PUNCT
admet-2874	455	3	mediated	mediate	VERB
admet-2874	455	4	regulation	regulation	NOUN
admet-2874	455	5	of	of	ADP
admet-2874	455	6	glucose	glucose	NOUN
admet-2874	455	7	and	and	CCONJ
admet-2874	455	8	lipid	lipid	NOUN
admet-2874	455	9	metabolism	metabolism	NOUN
admet-2874	455	10	:	:	PUNCT
admet-2874	455	11	implications	implication	NOUN
admet-2874	455	12	for	for	ADP
admet-2874	455	13	the	the	DET
admet-2874	455	14	pathogenesis	pathogenesis	NOUN
admet-2874	455	15	of	of	ADP
admet-2874	455	16	masld	masld	NOUN
admet-2874	455	17	.	.	PUNCT
admet-2874	456	1	frontiers	frontier	NOUN
admet-2874	456	2	in	in	ADP
admet-2874	456	3	endocrinology	endocrinology	NOUN
admet-2874	456	4	16	16	NUM
admet-2874	456	5	(	(	PUNCT
admet-2874	456	6	2025	2025	NUM
admet-2874	456	7	)	)	PUNCT
admet-2874	456	8	.	.	PUNCT
admet-2874	457	1	https://doi.org/10.3389/fendo.2025.1535382	https://doi.org/10.3389/fendo.2025.1535382	NOUN
admet-2874	458	1	49	49	NUM
admet-2874	458	2	.	.	PUNCT
admet-2874	459	1	d.w	d.w	NOUN
admet-2874	459	2	.	.	PROPN
admet-2874	459	3	zhang	zhang	PROPN
admet-2874	459	4	,	,	PUNCT
admet-2874	459	5	y.x	y.x	PROPN
admet-2874	459	6	.	.	PROPN
admet-2874	459	7	zhao	zhao	PROPN
admet-2874	459	8	,	,	PUNCT
admet-2874	459	9	d.	d.	PROPN
admet-2874	459	10	wei	wei	PROPN
admet-2874	459	11	,	,	PUNCT
admet-2874	459	12	y.l	y.l	PROPN
admet-2874	459	13	.	.	PROPN
admet-2874	459	14	li	li	PROPN
admet-2874	459	15	,	,	PUNCT
admet-2874	459	16	y.	y.	PROPN
admet-2874	459	17	zhang	zhang	PROPN
admet-2874	459	18	,	,	PUNCT
admet-2874	459	19	j.	j.	PROPN
admet-2874	459	20	wu	wu	PROPN
admet-2874	459	21	,	,	PUNCT
admet-2874	459	22	j.	j.	PROPN
admet-2874	459	23	xu	xu	PROPN
admet-2874	459	24	,	,	PUNCT
admet-2874	459	25	c.	c.	PROPN
admet-2874	459	26	chen	chen	PROPN
admet-2874	459	27	,	,	PUNCT
admet-2874	459	28	h.	h.	PROPN
admet-2874	459	29	tang	tang	PROPN
admet-2874	459	30	,	,	PUNCT
admet-2874	459	31	w.	w.	PROPN
admet-2874	459	32	zhang	zhang	PROPN
admet-2874	459	33	,	,	PUNCT
admet-2874	459	34	l.	l.	PROPN
admet-2874	459	35	gong	gong	PROPN
admet-2874	459	36	,	,	PUNCT
admet-2874	459	37	y.	y.	PROPN
admet-2874	459	38	han	han	PROPN
admet-2874	459	39	,	,	PUNCT
admet-2874	459	40	z.n	z.n	PROPN
admet-2874	459	41	.	.	PROPN
admet-2874	459	42	chen	chen	PROPN
admet-2874	459	43	,	,	PUNCT
admet-2874	459	44	h.	h.	PROPN
admet-2874	459	45	bian	bian	PROPN
admet-2874	459	46	.	.	PUNCT
admet-2874	459	47	hab18g	hab18g	PROPN
admet-2874	459	48	/	/	SYM
admet-2874	459	49	cd147	cd147	PROPN
admet-2874	459	50	promotes	promote	VERB
admet-2874	459	51	activation	activation	NOUN
admet-2874	459	52	of	of	ADP
admet-2874	459	53	hepatic	hepatic	ADJ
admet-2874	459	54	stellate	stellate	ADJ
admet-2874	459	55	cells	cell	NOUN
admet-2874	459	56	and	and	CCONJ
admet-2874	459	57	is	be	AUX
admet-2874	459	58	a	a	DET
admet-2874	459	59	target	target	NOUN
admet-2874	459	60	for	for	ADP
admet-2874	459	61	antibody	antibody	NOUN
admet-2874	459	62	therapy	therapy	NOUN
admet-2874	459	63	of	of	ADP
admet-2874	459	64	liver	liver	NOUN
admet-2874	459	65	fibrosis	fibrosis	NOUN
admet-2874	459	66	.	.	PUNCT
admet-2874	460	1	journal	journal	NOUN
admet-2874	460	2	of	of	ADP
admet-2874	460	3	hepatology	hepatology	NOUN
admet-2874	460	4	57	57	NUM
admet-2874	460	5	(	(	PUNCT
admet-2874	460	6	2012	2012	NUM
admet-2874	460	7	)	)	PUNCT
admet-2874	460	8	12831291	12831291	NUM
admet-2874	460	9	.	.	PUNCT
admet-2874	461	1	https://doi.org/10.1016/j.jhep.2012.07.042	https://doi.org/10.1016/j.jhep.2012.07.042	NUM
admet-2874	461	2	50	50	NUM
admet-2874	461	3	.	.	PUNCT
admet-2874	462	1	l.	l.	PROPN
admet-2874	462	2	pirola	pirola	PROPN
admet-2874	462	3	.	.	PUNCT
admet-2874	462	4	elafibranor	elafibranor	PROPN
admet-2874	462	5	,	,	PUNCT
admet-2874	462	6	a	a	DET
admet-2874	462	7	dual	dual	ADJ
admet-2874	462	8	pparα	pparα	NOUN
admet-2874	462	9	and	and	CCONJ
admet-2874	462	10	pparδ	pparδ	NOUN
admet-2874	462	11	agonist	agonist	NOUN
admet-2874	462	12	,	,	PUNCT
admet-2874	462	13	reduces	reduce	VERB
admet-2874	462	14	alcohol	alcohol	NOUN
admet-2874	462	15	-	-	PUNCT
admet-2874	462	16	associated	associate	VERB
admet-2874	462	17	liver	liver	NOUN
admet-2874	462	18	disease	disease	NOUN
admet-2874	462	19	:	:	PUNCT
admet-2874	462	20	lessons	lesson	NOUN
admet-2874	462	21	from	from	ADP
admet-2874	462	22	a	a	DET
admet-2874	462	23	mouse	mouse	NOUN
admet-2874	462	24	model	model	NOUN
admet-2874	462	25	.	.	PUNCT
admet-2874	463	1	world	world	PROPN
admet-2874	463	2	journal	journal	PROPN
admet-2874	463	3	of	of	ADP
admet-2874	463	4	gastroenterology	gastroenterology	NOUN
admet-2874	463	5	31	31	NUM
admet-2874	463	6	(	(	PUNCT
admet-2874	463	7	2025	2025	NUM
admet-2874	463	8	)	)	PUNCT
admet-2874	463	9	99312	99312	NUM
admet-2874	463	10	.	.	PUNCT
admet-2874	464	1	https://doi.org/10.3748/wjg.v31.i4.99312	https://doi.org/10.3748/wjg.v31.i4.99312	PROPN
admet-2874	464	2	https://doi.org/10.1371/journal.pone.0039307	https://doi.org/10.1371/journal.pone.0039307	PUNCT
admet-2874	464	3	https://doi.org/10.3389/fimmu.2018.01994	https://doi.org/10.3389/fimmu.2018.01994	PROPN
admet-2874	464	4	https://doi.org/10.1038/s41467-018-04450-y	https://doi.org/10.1038/s41467-018-04450-y	PROPN
admet-2874	464	5	https://doi.org/10.3389/fimmu.2019.00477	https://doi.org/10.3389/fimmu.2019.00477	PROPN
admet-2874	464	6	https://doi.org/10.1002/hep.28644	https://doi.org/10.1002/hep.28644	VERB
admet-2874	464	7	https://doi.org/10.1146/annurev-pharmtox-020524-012013	https://doi.org/10.1146/annurev-pharmtox-020524-012013	PROPN
admet-2874	464	8	https://doi.org/10.1016/j.jhep.2019.03.012	https://doi.org/10.1016/j.jhep.2019.03.012	PROPN
admet-2874	464	9	https://doi.org/10.1038/s41586-025-08677-w	https://doi.org/10.1038/s41586-025-08677-w	PROPN
admet-2874	464	10	https://doi.org/10.1016/j.jhepr.2024.101223	https://doi.org/10.1016/j.jhepr.2024.101223	PROPN
admet-2874	464	11	https://doi.org/10.3389/fendo.2025.1535382	https://doi.org/10.3389/fendo.2025.1535382	PART
admet-2874	464	12	https://doi.org/10.1016/j.jhep.2012.07.042	https://doi.org/10.1016/j.jhep.2012.07.042	NUM
admet-2874	464	13	https://doi.org/10.3748/wjg.v31.i4.99312	https://doi.org/10.3748/wjg.v31.i4.99312	PROPN
admet-2874	464	14	admet	admet	PROPN
admet-2874	464	15	&	&	CCONJ
admet-2874	464	16	dmpk	dmpk	PROPN
admet-2874	464	17	13(4	13(4	NUM
admet-2874	464	18	)	)	PUNCT
admet-2874	464	19	(	(	PUNCT
admet-2874	464	20	2025	2025	NUM
admet-2874	464	21	)	)	PUNCT
admet-2874	464	22	2874	2874	NUM
admet-2874	464	23	hscs	hsc	NOUN
admet-2874	464	24	in	in	ADP
admet-2874	464	25	liver	liver	NOUN
admet-2874	464	26	fibrosis	fibrosis	NOUN
admet-2874	464	27	:	:	PUNCT
admet-2874	464	28	therapeutic	therapeutic	ADJ
admet-2874	464	29	advances	advance	NOUN
admet-2874	464	30	doi	doi	NOUN
admet-2874	464	31	:	:	PUNCT
admet-2874	464	32	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PROPN
admet-2874	464	33	19	19	NUM
admet-2874	464	34	51	51	NUM
admet-2874	464	35	.	.	PUNCT
admet-2874	465	1	g.	g.	PROPN
admet-2874	465	2	huang	huang	PROPN
admet-2874	465	3	,	,	PUNCT
admet-2874	465	4	m.	m.	PROPN
admet-2874	465	5	zhang	zhang	PROPN
admet-2874	465	6	,	,	PUNCT
admet-2874	465	7	m.	m.	PROPN
admet-2874	465	8	wang	wang	PROPN
admet-2874	465	9	,	,	PUNCT
admet-2874	465	10	w.	w.	PROPN
admet-2874	465	11	xu	xu	PROPN
admet-2874	465	12	,	,	PUNCT
admet-2874	465	13	x.	x.	PROPN
admet-2874	465	14	duan	duan	PROPN
admet-2874	465	15	,	,	PUNCT
admet-2874	465	16	x.	x.	PROPN
admet-2874	465	17	han	han	PROPN
admet-2874	465	18	,	,	PUNCT
admet-2874	465	19	j.	j.	PROPN
admet-2874	465	20	ren	ren	PROPN
admet-2874	465	21	,	,	PUNCT
admet-2874	465	22	pioglitazone	pioglitazone	NOUN
admet-2874	465	23	.	.	PUNCT
admet-2874	466	1	a	a	DET
admet-2874	466	2	peroxisome	peroxisome	NOUN
admet-2874	466	3	proliferator	proliferator	NOUN
admet-2874	466	4	-	-	PUNCT
admet-2874	466	5	activated	activate	VERB
admet-2874	466	6	receptor	receptor	NOUN
admet-2874	466	7	γ	γ	NOUN
admet-2874	466	8	agonist	agonist	NOUN
admet-2874	466	9	,	,	PUNCT
admet-2874	466	10	induces	induce	VERB
admet-2874	466	11	cell	cell	NOUN
admet-2874	466	12	death	death	NOUN
admet-2874	466	13	and	and	CCONJ
admet-2874	466	14	inhibits	inhibit	VERB
admet-2874	466	15	the	the	DET
admet-2874	466	16	proliferation	proliferation	NOUN
admet-2874	466	17	of	of	ADP
admet-2874	466	18	hypoxic	hypoxic	ADV
admet-2874	466	19	hepg2	hepg2	VERB
admet-2874	466	20	cells	cell	NOUN
admet-2874	466	21	by	by	ADP
admet-2874	466	22	promoting	promote	VERB
admet-2874	466	23	excessive	excessive	ADJ
admet-2874	466	24	production	production	NOUN
admet-2874	466	25	of	of	ADP
admet-2874	466	26	reactive	reactive	ADJ
admet-2874	466	27	oxygen	oxygen	NOUN
admet-2874	466	28	species	specie	NOUN
admet-2874	466	29	.	.	PUNCT
admet-2874	467	1	oncology	oncology	NOUN
admet-2874	467	2	letters	letter	NOUN
admet-2874	467	3	27	27	NUM
admet-2874	467	4	(	(	PUNCT
admet-2874	467	5	2024	2024	NUM
admet-2874	467	6	)	)	PUNCT
admet-2874	467	7	160	160	NUM
admet-2874	467	8	.	.	PUNCT
admet-2874	468	1	https://doi.org/10.3892/ol.2024.14294	https://doi.org/10.3892/ol.2024.14294	NOUN
admet-2874	468	2	52	52	NUM
admet-2874	468	3	.	.	PUNCT
admet-2874	469	1	s.	s.	PROPN
admet-2874	469	2	fiorucci	fiorucci	PROPN
admet-2874	469	3	,	,	PUNCT
admet-2874	469	4	m.	m.	NOUN
admet-2874	469	5	biagioli	biagioli	PROPN
admet-2874	469	6	,	,	PUNCT
admet-2874	469	7	m.	m.	NOUN
admet-2874	469	8	baldoni	baldoni	PROPN
admet-2874	469	9	,	,	PUNCT
admet-2874	469	10	p.	p.	PROPN
admet-2874	469	11	ricci	ricci	PROPN
admet-2874	469	12	,	,	PUNCT
admet-2874	469	13	v.	v.	PROPN
admet-2874	469	14	sepe	sepe	PROPN
admet-2874	469	15	,	,	PUNCT
admet-2874	469	16	a.	a.	NOUN
admet-2874	469	17	zampella	zampella	PROPN
admet-2874	469	18	,	,	PUNCT
admet-2874	469	19	e.	e.	PROPN
admet-2874	469	20	distrutti	distrutti	PROPN
admet-2874	469	21	.	.	PUNCT
admet-2874	470	1	the	the	DET
admet-2874	470	2	identification	identification	NOUN
admet-2874	470	3	of	of	ADP
admet-2874	470	4	farnesoid	farnesoid	ADJ
admet-2874	470	5	x	x	NOUN
admet-2874	470	6	receptor	receptor	NOUN
admet-2874	470	7	modulators	modulator	NOUN
admet-2874	470	8	as	as	ADP
admet-2874	470	9	treatment	treatment	NOUN
admet-2874	470	10	options	option	NOUN
admet-2874	470	11	for	for	ADP
admet-2874	470	12	nonalcoholic	nonalcoholic	NOUN
admet-2874	470	13	fatty	fatty	NOUN
admet-2874	470	14	liver	liver	NOUN
admet-2874	470	15	disease	disease	NOUN
admet-2874	470	16	.	.	PUNCT
admet-2874	471	1	expert	expert	ADJ
admet-2874	471	2	opinion	opinion	NOUN
admet-2874	471	3	on	on	ADP
admet-2874	471	4	drug	drug	NOUN
admet-2874	471	5	discovery	discovery	NOUN
admet-2874	471	6	16	16	NUM
admet-2874	471	7	(	(	PUNCT
admet-2874	471	8	2021	2021	NUM
admet-2874	471	9	)	)	PUNCT
admet-2874	471	10	1193	1193	NUM
admet-2874	471	11	-	-	SYM
admet-2874	471	12	1208	1208	NUM
admet-2874	471	13	.	.	PUNCT
admet-2874	472	1	https://doi.org/10.1080/17460441.2021.1916465	https://doi.org/10.1080/17460441.2021.1916465	PROPN
admet-2874	473	1	53	53	NUM
admet-2874	473	2	.	.	PUNCT
admet-2874	474	1	v.	v.	PROPN
admet-2874	474	2	lekakis	lekakis	PROPN
admet-2874	474	3	,	,	PUNCT
admet-2874	474	4	e.	e.	PROPN
admet-2874	474	5	cholongitas	cholongitas	PROPN
admet-2874	474	6	.	.	PUNCT
admet-2874	475	1	the	the	DET
admet-2874	475	2	impact	impact	NOUN
admet-2874	475	3	of	of	ADP
admet-2874	475	4	emricasan	emricasan	NOUN
admet-2874	475	5	on	on	ADP
admet-2874	475	6	chronic	chronic	ADJ
admet-2874	475	7	liver	liver	NOUN
admet-2874	475	8	diseases	disease	NOUN
admet-2874	475	9	:	:	PUNCT
admet-2874	475	10	current	current	ADJ
admet-2874	475	11	data	datum	NOUN
admet-2874	475	12	.	.	PUNCT
admet-2874	476	1	clinical	clinical	ADJ
admet-2874	476	2	journal	journal	NOUN
admet-2874	476	3	of	of	ADP
admet-2874	476	4	gastroenterology	gastroenterology	NOUN
admet-2874	476	5	15	15	NUM
admet-2874	476	6	(	(	PUNCT
admet-2874	476	7	2022	2022	NUM
admet-2874	476	8	)	)	PUNCT
admet-2874	476	9	271	271	NUM
admet-2874	476	10	-	-	SYM
admet-2874	476	11	285	285	NUM
admet-2874	476	12	.	.	PUNCT
admet-2874	477	1	https://doi.org/10.1007/s12328-02101585-2	https://doi.org/10.1007/s12328-02101585-2	PROPN
admet-2874	477	2	54	54	NUM
admet-2874	477	3	.	.	PUNCT
admet-2874	478	1	s.a	s.a	PROPN
admet-2874	478	2	.	.	PROPN
admet-2874	478	3	harrison	harrison	PROPN
admet-2874	478	4	,	,	PUNCT
admet-2874	478	5	p.	p.	NOUN
admet-2874	478	6	bedossa	bedossa	NOUN
admet-2874	478	7	,	,	PUNCT
admet-2874	478	8	c.d	c.d	PROPN
admet-2874	478	9	.	.	PROPN
admet-2874	478	10	guy	guy	PROPN
admet-2874	478	11	,	,	PUNCT
admet-2874	478	12	j.m	j.m	PROPN
admet-2874	478	13	.	.	PROPN
admet-2874	478	14	schattenberg	schattenberg	PROPN
admet-2874	478	15	,	,	PUNCT
admet-2874	478	16	r.	r.	PROPN
admet-2874	478	17	loomba	loomba	PROPN
admet-2874	478	18	,	,	PUNCT
admet-2874	478	19	r.	r.	PROPN
admet-2874	478	20	taub	taub	PROPN
admet-2874	478	21	,	,	PUNCT
admet-2874	478	22	d.	d.	PROPN
admet-2874	478	23	labriola	labriola	PROPN
admet-2874	478	24	,	,	PUNCT
admet-2874	478	25	s.e	s.e	PROPN
admet-2874	478	26	.	.	PROPN
admet-2874	478	27	moussa	moussa	PROPN
admet-2874	478	28	,	,	PUNCT
admet-2874	478	29	g.w	g.w	PROPN
admet-2874	478	30	.	.	PROPN
admet-2874	478	31	neff	neff	PROPN
admet-2874	478	32	,	,	PUNCT
admet-2874	478	33	m.e	m.e	PROPN
admet-2874	478	34	.	.	PROPN
admet-2874	478	35	rinella	rinella	PROPN
admet-2874	478	36	,	,	PUNCT
admet-2874	478	37	q.m	q.m	PROPN
admet-2874	478	38	.	.	PROPN
admet-2874	478	39	anstee	anstee	PROPN
admet-2874	478	40	,	,	PUNCT
admet-2874	478	41	m.f	m.f	PROPN
admet-2874	478	42	.	.	PROPN
admet-2874	478	43	abdelmalek	abdelmalek	PROPN
admet-2874	478	44	,	,	PUNCT
admet-2874	478	45	z.	z.	PROPN
admet-2874	478	46	younossi	younossi	PROPN
admet-2874	478	47	,	,	PUNCT
admet-2874	478	48	s.j	s.j	PROPN
admet-2874	478	49	.	.	PROPN
admet-2874	478	50	baum	baum	PROPN
admet-2874	478	51	,	,	PUNCT
admet-2874	478	52	s.	s.	PROPN
admet-2874	478	53	francque	francque	PROPN
admet-2874	478	54	,	,	PUNCT
admet-2874	478	55	m.r	m.r	PROPN
admet-2874	478	56	.	.	PROPN
admet-2874	478	57	charlton	charlton	PROPN
admet-2874	478	58	,	,	PUNCT
admet-2874	478	59	p.n	p.n	PROPN
admet-2874	478	60	.	.	PROPN
admet-2874	478	61	newsome	newsome	PROPN
admet-2874	478	62	,	,	PUNCT
admet-2874	478	63	n.	n.	NOUN
admet-2874	478	64	lanthier	lanthier	NOUN
admet-2874	478	65	,	,	PUNCT
admet-2874	478	66	i.	i.	PROPN
admet-2874	478	67	schiefke	schiefke	NOUN
admet-2874	478	68	,	,	PUNCT
admet-2874	478	69	a.	a.	PROPN
admet-2874	478	70	mangia	mangia	PROPN
admet-2874	478	71	,	,	PUNCT
admet-2874	478	72	j.m	j.m	PROPN
admet-2874	478	73	.	.	PROPN
admet-2874	478	74	pericàs	pericàs	PROPN
admet-2874	478	75	,	,	PUNCT
admet-2874	478	76	r.	r.	PROPN
admet-2874	478	77	patil	patil	PROPN
admet-2874	478	78	,	,	PUNCT
admet-2874	478	79	a.j	a.j	PROPN
admet-2874	478	80	.	.	PROPN
admet-2874	478	81	sanyal	sanyal	PROPN
admet-2874	478	82	,	,	PUNCT
admet-2874	478	83	m.	m.	NOUN
admet-2874	478	84	noureddin	noureddin	PROPN
admet-2874	478	85	,	,	PUNCT
admet-2874	478	86	m.b	m.b	PROPN
admet-2874	478	87	.	.	PROPN
admet-2874	478	88	bansal	bansal	PROPN
admet-2874	478	89	,	,	PUNCT
admet-2874	478	90	n.	n.	PROPN
admet-2874	478	91	alkhouri	alkhouri	PROPN
admet-2874	478	92	,	,	PUNCT
admet-2874	478	93	l.	l.	PROPN
admet-2874	478	94	castera	castera	PROPN
admet-2874	478	95	,	,	PUNCT
admet-2874	478	96	m.	m.	NOUN
admet-2874	478	97	rudraraju	rudraraju	PROPN
admet-2874	478	98	,	,	PUNCT
admet-2874	478	99	v.	v.	ADP
admet-2874	478	100	ratziu	ratziu	NOUN
admet-2874	478	101	.	.	PUNCT
admet-2874	479	1	a	a	DET
admet-2874	479	2	phase	phase	NOUN
admet-2874	479	3	3	3	NUM
admet-2874	479	4	,	,	PUNCT
admet-2874	479	5	randomized	randomize	VERB
admet-2874	479	6	,	,	PUNCT
admet-2874	479	7	controlled	control	VERB
admet-2874	479	8	trial	trial	NOUN
admet-2874	479	9	of	of	ADP
admet-2874	479	10	resmetirom	resmetirom	ADJ
admet-2874	479	11	in	in	ADP
admet-2874	479	12	nash	nash	NOUN
admet-2874	479	13	with	with	ADP
admet-2874	479	14	liver	liver	NOUN
admet-2874	479	15	fibrosis	fibrosis	NOUN
admet-2874	479	16	.	.	PUNCT
admet-2874	480	1	new	new	PROPN
admet-2874	480	2	england	england	PROPN
admet-2874	480	3	journal	journal	PROPN
admet-2874	480	4	of	of	ADP
admet-2874	480	5	medicine	medicine	NOUN
admet-2874	480	6	390	390	NUM
admet-2874	480	7	(	(	PUNCT
admet-2874	480	8	2024	2024	NUM
admet-2874	480	9	)	)	PUNCT
admet-2874	480	10	497	497	NUM
admet-2874	480	11	-	-	SYM
admet-2874	480	12	509	509	NUM
admet-2874	480	13	.	.	PUNCT
admet-2874	480	14	https://doi.org/10.1056/nejmoa2309000	https://doi.org/10.1056/nejmoa2309000	PROPN
admet-2874	480	15	55	55	NUM
admet-2874	480	16	.	.	PUNCT
admet-2874	481	1	x.	x.	PROPN
admet-2874	481	2	xu	xu	PROPN
admet-2874	481	3	,	,	PUNCT
admet-2874	481	4	y.	y.	PROPN
admet-2874	481	5	guo	guo	PROPN
admet-2874	481	6	,	,	PUNCT
admet-2874	481	7	x.	x.	PROPN
admet-2874	481	8	luo	luo	PROPN
admet-2874	481	9	,	,	PUNCT
admet-2874	481	10	z.	z.	PROPN
admet-2874	481	11	shen	shen	PROPN
admet-2874	481	12	,	,	PUNCT
admet-2874	481	13	z.	z.	PROPN
admet-2874	481	14	sun	sun	PROPN
admet-2874	481	15	,	,	PUNCT
admet-2874	481	16	b.	b.	PROPN
admet-2874	481	17	shen	shen	PROPN
admet-2874	481	18	,	,	PUNCT
admet-2874	481	19	c.	c.	PROPN
admet-2874	481	20	zhou	zhou	PROPN
admet-2874	481	21	,	,	PUNCT
admet-2874	481	22	j.	j.	PROPN
admet-2874	481	23	wang	wang	PROPN
admet-2874	481	24	,	,	PUNCT
admet-2874	481	25	j.	j.	PROPN
admet-2874	481	26	lu	lu	PROPN
admet-2874	481	27	,	,	PUNCT
admet-2874	481	28	q.	q.	PROPN
admet-2874	481	29	zhang	zhang	PROPN
admet-2874	481	30	,	,	PUNCT
admet-2874	481	31	y.	y.	PROPN
admet-2874	481	32	ye	ye	PROPN
admet-2874	481	33	,	,	PUNCT
admet-2874	481	34	y.	y.	PROPN
admet-2874	481	35	luo	luo	PROPN
admet-2874	481	36	,	,	PUNCT
admet-2874	481	37	y.	y.	PROPN
admet-2874	481	38	qu	qu	PROPN
admet-2874	481	39	,	,	PUNCT
admet-2874	481	40	x.	x.	PROPN
admet-2874	481	41	cai	cai	PROPN
admet-2874	481	42	,	,	PUNCT
admet-2874	481	43	h.	h.	PROPN
admet-2874	481	44	dong	dong	PROPN
admet-2874	481	45	,	,	PUNCT
admet-2874	481	46	l.	l.	PROPN
admet-2874	481	47	lu	lu	PROPN
admet-2874	481	48	.	.	PUNCT
admet-2874	482	1	hydronidone	hydronidone	PROPN
admet-2874	482	2	ameliorates	ameliorate	VERB
admet-2874	482	3	liver	liver	NOUN
admet-2874	482	4	fibrosis	fibrosis	NOUN
admet-2874	482	5	by	by	ADP
admet-2874	482	6	inhibiting	inhibit	VERB
admet-2874	482	7	activation	activation	NOUN
admet-2874	482	8	of	of	ADP
admet-2874	482	9	hepatic	hepatic	ADJ
admet-2874	482	10	stellate	stellate	ADJ
admet-2874	482	11	cells	cell	NOUN
admet-2874	482	12	via	via	ADP
admet-2874	482	13	smad7	smad7	NOUN
admet-2874	482	14	-	-	PUNCT
admet-2874	482	15	mediated	mediate	VERB
admet-2874	482	16	degradation	degradation	NOUN
admet-2874	482	17	of	of	ADP
admet-2874	482	18	tgfβri	tgfβri	NOUN
admet-2874	482	19	.	.	PUNCT
admet-2874	483	1	liver	liver	PROPN
admet-2874	483	2	international	international	ADJ
admet-2874	483	3	43	43	NUM
admet-2874	483	4	(	(	PUNCT
admet-2874	483	5	2023	2023	NUM
admet-2874	483	6	)	)	PUNCT
admet-2874	483	7	2523	2523	NUM
admet-2874	483	8	-	-	SYM
admet-2874	483	9	2537	2537	NUM
admet-2874	483	10	.	.	PUNCT
admet-2874	484	1	https://doi.org/10.1111/liv.15715	https://doi.org/10.1111/liv.15715	NOUN
admet-2874	484	2	56	56	NUM
admet-2874	484	3	.	.	PUNCT
admet-2874	485	1	n.	n.	PROPN
admet-2874	485	2	chalasani	chalasani	PROPN
admet-2874	485	3	,	,	PUNCT
admet-2874	485	4	m.f	m.f	PROPN
admet-2874	485	5	.	.	PROPN
admet-2874	485	6	abdelmalek	abdelmalek	PROPN
admet-2874	485	7	,	,	PUNCT
admet-2874	485	8	g.	g.	PROPN
admet-2874	485	9	garcia	garcia	PROPN
admet-2874	485	10	-	-	PUNCT
admet-2874	485	11	tsao	tsao	PROPN
admet-2874	485	12	,	,	PUNCT
admet-2874	485	13	r.	r.	PROPN
admet-2874	485	14	vuppalanchi	vuppalanchi	PROPN
admet-2874	485	15	,	,	PUNCT
admet-2874	485	16	n.	n.	PROPN
admet-2874	485	17	alkhouri	alkhouri	PROPN
admet-2874	485	18	,	,	PUNCT
admet-2874	485	19	m.	m.	NOUN
admet-2874	485	20	rinella	rinella	PROPN
admet-2874	485	21	,	,	PUNCT
admet-2874	485	22	m.	m.	NOUN
admet-2874	485	23	noureddin	noureddin	NOUN
admet-2874	485	24	,	,	PUNCT
admet-2874	485	25	m.	m.	NOUN
admet-2874	485	26	pyko	pyko	NOUN
admet-2874	485	27	,	,	PUNCT
admet-2874	485	28	m.	m.	NOUN
admet-2874	485	29	shiffman	shiffman	PROPN
admet-2874	485	30	,	,	PUNCT
admet-2874	485	31	a.	a.	NOUN
admet-2874	485	32	sanyal	sanyal	PROPN
admet-2874	485	33	,	,	PUNCT
admet-2874	485	34	a.	a.	NOUN
admet-2874	485	35	allgood	allgood	PROPN
admet-2874	485	36	,	,	PUNCT
admet-2874	485	37	h.	h.	PROPN
admet-2874	485	38	shlevin	shlevin	PROPN
admet-2874	485	39	,	,	PUNCT
admet-2874	485	40	r.	r.	PROPN
admet-2874	485	41	horton	horton	PROPN
admet-2874	485	42	,	,	PUNCT
admet-2874	485	43	e.	e.	PROPN
admet-2874	485	44	zomer	zomer	PROPN
admet-2874	485	45	,	,	PUNCT
admet-2874	485	46	w.	w.	PROPN
admet-2874	485	47	irish	irish	PROPN
admet-2874	485	48	,	,	PUNCT
admet-2874	485	49	z.	z.	PROPN
admet-2874	485	50	goodman	goodman	PROPN
admet-2874	485	51	,	,	PUNCT
admet-2874	485	52	s.a	s.a	PROPN
admet-2874	485	53	.	.	PROPN
admet-2874	485	54	harrison	harrison	PROPN
admet-2874	485	55	,	,	PUNCT
admet-2874	485	56	p.g	p.g	PROPN
admet-2874	485	57	.	.	PROPN
admet-2874	485	58	traber	traber	PROPN
admet-2874	485	59	,	,	PUNCT
admet-2874	485	60	l.	l.	PROPN
admet-2874	485	61	balart	balart	PROPN
admet-2874	485	62	,	,	PUNCT
admet-2874	485	63	b.	b.	PROPN
admet-2874	485	64	borg	borg	PROPN
admet-2874	485	65	,	,	PUNCT
admet-2874	485	66	m.	m.	NOUN
admet-2874	485	67	charlton	charlton	PROPN
admet-2874	485	68	,	,	PUNCT
admet-2874	485	69	h.	h.	PROPN
admet-2874	485	70	conjeevaram	conjeevaram	PROPN
admet-2874	485	71	,	,	PUNCT
admet-2874	485	72	m.	m.	NOUN
admet-2874	485	73	fuchs	fuchs	PROPN
admet-2874	485	74	,	,	PUNCT
admet-2874	485	75	r.	r.	PROPN
admet-2874	485	76	ghalib	ghalib	PROPN
admet-2874	485	77	,	,	PUNCT
admet-2874	485	78	p.	p.	PROPN
admet-2874	485	79	gholam	gholam	PROPN
admet-2874	485	80	,	,	PUNCT
admet-2874	485	81	d.	d.	PROPN
admet-2874	485	82	halegoua	halegoua	PROPN
admet-2874	485	83	-	-	PUNCT
admet-2874	485	84	de	de	X
admet-2874	485	85	marzio	marzio	NOUN
admet-2874	485	86	,	,	PUNCT
admet-2874	485	87	s.	s.	PROPN
admet-2874	485	88	harrison	harrison	PROPN
admet-2874	485	89	,	,	PUNCT
admet-2874	485	90	c.	c.	PROPN
admet-2874	485	91	jue	jue	PROPN
admet-2874	485	92	,	,	PUNCT
admet-2874	485	93	n.	n.	PROPN
admet-2874	485	94	kemmer	kemmer	PROPN
admet-2874	485	95	,	,	PUNCT
admet-2874	485	96	k.	k.	PROPN
admet-2874	485	97	kowdley	kowdley	PROPN
admet-2874	485	98	,	,	PUNCT
admet-2874	485	99	m.	m.	PROPN
admet-2874	485	100	lai	lai	PROPN
admet-2874	485	101	,	,	PUNCT
admet-2874	485	102	e.	e.	PROPN
admet-2874	485	103	lawitz	lawitz	PROPN
admet-2874	485	104	,	,	PUNCT
admet-2874	485	105	r.	r.	PROPN
admet-2874	485	106	loomba	loomba	PROPN
admet-2874	485	107	,	,	PUNCT
admet-2874	485	108	a.	a.	NOUN
admet-2874	485	109	paredes	paredes	PROPN
admet-2874	485	110	,	,	PUNCT
admet-2874	485	111	d.	d.	PROPN
admet-2874	485	112	rockey	rockey	PROPN
admet-2874	485	113	,	,	PUNCT
admet-2874	485	114	m.	m.	PROPN
admet-2874	485	115	rodriguez	rodriguez	PROPN
admet-2874	485	116	,	,	PUNCT
admet-2874	485	117	r.	r.	PROPN
admet-2874	485	118	rubin	rubin	PROPN
admet-2874	485	119	,	,	PUNCT
admet-2874	485	120	m.	m.	PROPN
admet-2874	485	121	ryan	ryan	PROPN
admet-2874	485	122	,	,	PUNCT
admet-2874	485	123	a.	a.	NOUN
admet-2874	485	124	scanga	scanga	PROPN
admet-2874	485	125	,	,	PUNCT
admet-2874	485	126	t.	t.	PROPN
admet-2874	485	127	sepe	sepe	PROPN
admet-2874	485	128	,	,	PUNCT
admet-2874	485	129	b.	b.	PROPN
admet-2874	485	130	tetri	tetri	PROPN
admet-2874	485	131	,	,	PUNCT
admet-2874	485	132	p.	p.	PROPN
admet-2874	485	133	thuluvath	thuluvath	NOUN
admet-2874	485	134	,	,	PUNCT
admet-2874	485	135	d.	d.	PROPN
admet-2874	485	136	torres	torres	PROPN
admet-2874	485	137	,	,	PUNCT
admet-2874	485	138	j.	j.	PROPN
admet-2874	485	139	vierling	vierling	PROPN
admet-2874	485	140	,	,	PUNCT
admet-2874	485	141	j.	j.	PROPN
admet-2874	485	142	wattacheril	wattacheril	PROPN
admet-2874	485	143	,	,	PUNCT
admet-2874	485	144	a.	a.	PROPN
admet-2874	485	145	weiland	weiland	PROPN
admet-2874	485	146	,	,	PUNCT
admet-2874	485	147	d.	d.	PROPN
admet-2874	485	148	zogg	zogg	PROPN
admet-2874	485	149	.	.	PUNCT
admet-2874	486	1	effects	effect	NOUN
admet-2874	486	2	of	of	ADP
admet-2874	486	3	belapectin	belapectin	NOUN
admet-2874	486	4	,	,	PUNCT
admet-2874	486	5	an	an	DET
admet-2874	486	6	inhibitor	inhibitor	NOUN
admet-2874	486	7	of	of	ADP
admet-2874	486	8	galectin-3	galectin-3	PROPN
admet-2874	486	9	,	,	PUNCT
admet-2874	486	10	in	in	ADP
admet-2874	486	11	patients	patient	NOUN
admet-2874	486	12	with	with	ADP
admet-2874	486	13	nonalcoholic	nonalcoholic	PROPN
admet-2874	486	14	steatohepatitis	steatohepatitis	NOUN
admet-2874	486	15	with	with	ADP
admet-2874	486	16	cirrhosis	cirrhosis	NOUN
admet-2874	486	17	and	and	CCONJ
admet-2874	486	18	portal	portal	ADJ
admet-2874	486	19	hypertension	hypertension	NOUN
admet-2874	486	20	.	.	PUNCT
admet-2874	487	1	gastroenterology	gastroenterology	NOUN
admet-2874	487	2	158	158	NUM
admet-2874	487	3	(	(	PUNCT
admet-2874	487	4	2020	2020	NUM
admet-2874	487	5	)	)	PUNCT
admet-2874	487	6	1334	1334	NUM
admet-2874	487	7	-	-	SYM
admet-2874	487	8	1345.e5	1345.e5	NUM
admet-2874	487	9	.	.	PUNCT
admet-2874	488	1	https://doi.org/10.1053/j.gastro.2019.11.296	https://doi.org/10.1053/j.gastro.2019.11.296	NOUN
admet-2874	488	2	57	57	NUM
admet-2874	488	3	.	.	PUNCT
admet-2874	489	1	s.	s.	PROPN
admet-2874	489	2	petta	petta	PROPN
admet-2874	489	3	,	,	PUNCT
admet-2874	489	4	g.	g.	PROPN
admet-2874	489	5	targher	targher	PROPN
admet-2874	489	6	,	,	PUNCT
admet-2874	489	7	s.	s.	PROPN
admet-2874	489	8	romeo	romeo	PROPN
admet-2874	489	9	,	,	PUNCT
admet-2874	489	10	u.b	u.b	PROPN
admet-2874	489	11	.	.	PROPN
admet-2874	489	12	pajvani	pajvani	PROPN
admet-2874	489	13	,	,	PUNCT
admet-2874	489	14	m.h	m.h	PROPN
admet-2874	489	15	.	.	PROPN
admet-2874	489	16	zheng	zheng	PROPN
admet-2874	489	17	,	,	PUNCT
admet-2874	489	18	a.	a.	NOUN
admet-2874	489	19	aghemo	aghemo	PROPN
admet-2874	489	20	,	,	PUNCT
admet-2874	489	21	l.v.c	l.v.c	PROPN
admet-2874	489	22	.	.	PUNCT
admet-2874	489	23	valenti	valenti	PROPN
admet-2874	489	24	.	.	PUNCT
admet-2874	490	1	the	the	DET
admet-2874	490	2	first	first	ADJ
admet-2874	490	3	mash	mash	NOUN
admet-2874	490	4	drug	drug	NOUN
admet-2874	490	5	therapy	therapy	NOUN
admet-2874	490	6	on	on	ADP
admet-2874	490	7	the	the	DET
admet-2874	490	8	horizon	horizon	NOUN
admet-2874	490	9	:	:	PUNCT
admet-2874	490	10	current	current	ADJ
admet-2874	490	11	perspectives	perspective	NOUN
admet-2874	490	12	of	of	ADP
admet-2874	490	13	resmetirom	resmetirom	PROPN
admet-2874	490	14	.	.	PUNCT
admet-2874	491	1	liver	liver	PROPN
admet-2874	491	2	international	international	ADJ
admet-2874	491	3	44	44	NUM
admet-2874	491	4	(	(	PUNCT
admet-2874	491	5	2024	2024	NUM
admet-2874	491	6	)	)	PUNCT
admet-2874	491	7	1526	1526	NUM
admet-2874	491	8	-	-	SYM
admet-2874	491	9	1536	1536	NUM
admet-2874	491	10	.	.	PUNCT
admet-2874	492	1	https://doi.org/10.1111/liv.15930	https://doi.org/10.1111/liv.15930	PROPN
admet-2874	492	2	58	58	NUM
admet-2874	492	3	.	.	PUNCT
admet-2874	493	1	m.	m.	PROPN
admet-2874	493	2	kram	kram	PROPN
admet-2874	493	3	.	.	PUNCT
admet-2874	494	1	galectin-3	galectin-3	PROPN
admet-2874	494	2	inhibition	inhibition	VERB
admet-2874	494	3	as	as	ADP
admet-2874	494	4	a	a	DET
admet-2874	494	5	potential	potential	ADJ
admet-2874	494	6	therapeutic	therapeutic	ADJ
admet-2874	494	7	target	target	NOUN
admet-2874	494	8	in	in	ADP
admet-2874	494	9	nonalcoholic	nonalcoholic	NOUN
admet-2874	494	10	steatohepatitis	steatohepatitis	NOUN
admet-2874	494	11	liver	liver	NOUN
admet-2874	494	12	fibrosis	fibrosis	NOUN
admet-2874	494	13	.	.	PUNCT
admet-2874	495	1	world	world	PROPN
admet-2874	495	2	journal	journal	PROPN
admet-2874	495	3	of	of	ADP
admet-2874	495	4	hepatology	hepatology	NOUN
admet-2874	495	5	15	15	NUM
admet-2874	495	6	(	(	PUNCT
admet-2874	495	7	2023	2023	NUM
admet-2874	495	8	)	)	PUNCT
admet-2874	495	9	201	201	NUM
admet-2874	495	10	-	-	SYM
admet-2874	495	11	207	207	NUM
admet-2874	495	12	.	.	PUNCT
admet-2874	496	1	https://doi.org/10.4254/wjh.v15.i2.201	https://doi.org/10.4254/wjh.v15.i2.201	NOUN
admet-2874	496	2	59	59	NUM
admet-2874	496	3	.	.	PUNCT
admet-2874	497	1	s.a	s.a	PROPN
admet-2874	497	2	.	.	PROPN
admet-2874	497	3	nasir	nasir	PROPN
admet-2874	497	4	,	,	PUNCT
admet-2874	497	5	a.	a.	PROPN
admet-2874	497	6	mangla	mangla	PROPN
admet-2874	497	7	,	,	PUNCT
admet-2874	497	8	v.	v.	CCONJ
admet-2874	497	9	taneja	taneja	PROPN
admet-2874	497	10	,	,	PUNCT
admet-2874	497	11	t.	t.	PROPN
admet-2874	497	12	berger	berger	PROPN
admet-2874	497	13	,	,	PUNCT
admet-2874	497	14	d.	d.	PROPN
admet-2874	497	15	pandya	pandya	PROPN
admet-2874	497	16	,	,	PUNCT
admet-2874	497	17	v.	v.	PROPN
admet-2874	497	18	gupta	gupta	PROPN
admet-2874	497	19	,	,	PUNCT
admet-2874	497	20	j.k	j.k	PROPN
admet-2874	497	21	.	.	PROPN
admet-2874	497	22	lim	lim	PROPN
admet-2874	497	23	.	.	PUNCT
admet-2874	497	24	advances	advance	NOUN
admet-2874	497	25	in	in	ADP
admet-2874	497	26	novel	novel	ADJ
admet-2874	497	27	drug	drug	NOUN
admet-2874	497	28	therapy	therapy	NOUN
admet-2874	497	29	for	for	ADP
admet-2874	497	30	metabolic	metabolic	NOUN
admet-2874	497	31	dysfunction	dysfunction	NOUN
admet-2874	497	32	-	-	PUNCT
admet-2874	497	33	associated	associate	VERB
admet-2874	497	34	steatohepatitis	steatohepatitis	NOUN
admet-2874	497	35	cirrhosis	cirrhosis	NOUN
admet-2874	497	36	.	.	PUNCT
admet-2874	498	1	journal	journal	PROPN
admet-2874	498	2	of	of	ADP
admet-2874	498	3	translational	translational	ADJ
admet-2874	498	4	gastroenterology	gastroenterology	NOUN
admet-2874	498	5	3	3	NUM
admet-2874	498	6	(	(	PUNCT
admet-2874	498	7	2025	2025	NUM
admet-2874	498	8	)	)	PUNCT
admet-2874	498	9	9	9	NUM
admet-2874	498	10	-	-	SYM
admet-2874	498	11	17	17	NUM
admet-2874	498	12	.	.	PUNCT
admet-2874	499	1	https://doi.org/10.14218/jtg.2024.00040	https://doi.org/10.14218/jtg.2024.00040	VERB
admet-2874	499	2	60	60	NUM
admet-2874	499	3	.	.	PUNCT
admet-2874	500	1	d.	d.	PROPN
admet-2874	500	2	ezhilarasan	ezhilarasan	PROPN
admet-2874	500	3	.	.	PUNCT
admet-2874	501	1	deciphering	decipher	VERB
admet-2874	501	2	the	the	DET
admet-2874	501	3	molecular	molecular	ADJ
admet-2874	501	4	pathways	pathway	NOUN
admet-2874	501	5	of	of	ADP
admet-2874	501	6	saroglitazar	saroglitazar	NOUN
admet-2874	501	7	:	:	PUNCT
admet-2874	501	8	a	a	DET
admet-2874	501	9	dual	dual	ADJ
admet-2874	501	10	ppar	ppar	NOUN
admet-2874	501	11	α	α	X
admet-2874	501	12	/	/	SYM
admet-2874	501	13	γ	γ	NOUN
admet-2874	501	14	agonist	agonist	NOUN
admet-2874	501	15	for	for	ADP
admet-2874	501	16	managing	manage	VERB
admet-2874	501	17	metabolic	metabolic	NOUN
admet-2874	501	18	nafld	nafld	PROPN
admet-2874	501	19	.	.	PUNCT
admet-2874	502	1	metabolism	metabolism	NOUN
admet-2874	502	2	155	155	NUM
admet-2874	502	3	(	(	PUNCT
admet-2874	502	4	2024	2024	NUM
admet-2874	502	5	)	)	PUNCT
admet-2874	502	6	155912	155912	NUM
admet-2874	502	7	.	.	PUNCT
admet-2874	503	1	https://doi.org/10.1016/j.metabol.2024.155912	https://doi.org/10.1016/j.metabol.2024.155912	PROPN
admet-2874	503	2	61	61	NUM
admet-2874	503	3	.	.	PUNCT
admet-2874	504	1	c.m	c.m	PROPN
admet-2874	504	2	.	.	PROPN
admet-2874	504	3	hayes	hayes	PROPN
admet-2874	504	4	,	,	PUNCT
admet-2874	504	5	g.m	g.m	PROPN
admet-2874	504	6	.	.	PROPN
admet-2874	504	7	gallucci	gallucci	PROPN
admet-2874	504	8	,	,	PUNCT
admet-2874	504	9	j.l	j.l	PROPN
admet-2874	504	10	.	.	PROPN
admet-2874	504	11	boyer	boyer	PROPN
admet-2874	504	12	,	,	PUNCT
admet-2874	504	13	d.n	d.n	PROPN
admet-2874	504	14	.	.	PROPN
admet-2874	504	15	assis	assis	PROPN
admet-2874	504	16	,	,	PUNCT
admet-2874	504	17	n.s	n.s	PROPN
admet-2874	504	18	.	.	PROPN
admet-2874	504	19	ghonem	ghonem	PROPN
admet-2874	504	20	.	.	PUNCT
admet-2874	505	1	ppar	ppar	NOUN
admet-2874	505	2	agonists	agonist	NOUN
admet-2874	505	3	for	for	ADP
admet-2874	505	4	the	the	DET
admet-2874	505	5	treatment	treatment	NOUN
admet-2874	505	6	of	of	ADP
admet-2874	505	7	cholestatic	cholestatic	ADJ
admet-2874	505	8	liver	liver	NOUN
admet-2874	505	9	diseases	disease	NOUN
admet-2874	505	10	:	:	PUNCT
admet-2874	505	11	over	over	ADP
admet-2874	505	12	a	a	DET
admet-2874	505	13	decade	decade	NOUN
admet-2874	505	14	of	of	ADP
admet-2874	505	15	clinical	clinical	ADJ
admet-2874	505	16	progress	progress	NOUN
admet-2874	505	17	.	.	PUNCT
admet-2874	506	1	hepatology	hepatology	NOUN
admet-2874	506	2	communications	communication	NOUN
admet-2874	506	3	9	9	NUM
admet-2874	506	4	(	(	PUNCT
admet-2874	506	5	2024	2024	NUM
admet-2874	506	6	)	)	PUNCT
admet-2874	506	7	.	.	PUNCT
admet-2874	507	1	https://doi.org/10.1097/hc9.0000000000000612	https://doi.org/10.1097/hc9.0000000000000612	PROPN
admet-2874	507	2	62	62	NUM
admet-2874	507	3	.	.	PUNCT
admet-2874	508	1	s.j	s.j	PROPN
admet-2874	508	2	.	.	PROPN
admet-2874	508	3	keam	keam	PROPN
admet-2874	508	4	.	.	PUNCT
admet-2874	509	1	resmetirom	resmetirom	VERB
admet-2874	509	2	:	:	PUNCT
admet-2874	509	3	first	first	ADJ
admet-2874	509	4	approval	approval	NOUN
admet-2874	509	5	.	.	PUNCT
admet-2874	510	1	drugs	drug	NOUN
admet-2874	510	2	84	84	NUM
admet-2874	510	3	(	(	PUNCT
admet-2874	510	4	2024	2024	NUM
admet-2874	510	5	)	)	PUNCT
admet-2874	510	6	729	729	NUM
admet-2874	510	7	-	-	SYM
admet-2874	510	8	735	735	NUM
admet-2874	510	9	.	.	PUNCT
admet-2874	510	10	https://doi.org/10.1007/s40265-024-02045-0	https://doi.org/10.1007/s40265-024-02045-0	NUM
admet-2874	510	11	63	63	NUM
admet-2874	510	12	.	.	PUNCT
admet-2874	511	1	j.m	j.m	PROPN
admet-2874	511	2	.	.	PUNCT
admet-2874	512	1	yabut	yabut	PROPN
admet-2874	512	2	,	,	PUNCT
admet-2874	512	3	d.j	d.j	PROPN
admet-2874	512	4	.	.	PROPN
admet-2874	512	5	drucker	drucker	PROPN
admet-2874	512	6	.	.	PUNCT
admet-2874	513	1	glucagon	glucagon	NOUN
admet-2874	513	2	-	-	PUNCT
admet-2874	513	3	like	like	ADJ
admet-2874	513	4	peptide-1	peptide-1	NOUN
admet-2874	513	5	receptor	receptor	NOUN
admet-2874	513	6	-	-	PUNCT
admet-2874	513	7	based	base	VERB
admet-2874	513	8	therapeutics	therapeutic	NOUN
admet-2874	513	9	for	for	ADP
admet-2874	513	10	metabolic	metabolic	NOUN
admet-2874	513	11	liver	liver	NOUN
admet-2874	513	12	disease	disease	NOUN
admet-2874	513	13	.	.	PUNCT
admet-2874	514	1	endocrine	endocrine	PROPN
admet-2874	514	2	reviews	review	NOUN
admet-2874	514	3	44	44	NUM
admet-2874	514	4	(	(	PUNCT
admet-2874	514	5	2023	2023	NUM
admet-2874	514	6	)	)	PUNCT
admet-2874	514	7	14	14	NUM
admet-2874	514	8	-	-	SYM
admet-2874	514	9	32	32	NUM
admet-2874	514	10	.	.	PUNCT
admet-2874	515	1	https://doi.org/10.1210/endrev/bnac018	https://doi.org/10.1210/endrev/bnac018	PROPN
admet-2874	516	1	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	VERB
admet-2874	516	2	https://doi.org/10.3892/ol.2024.14294	https://doi.org/10.3892/ol.2024.14294	NOUN
admet-2874	516	3	https://doi.org/10.1080/17460441.2021.1916465	https://doi.org/10.1080/17460441.2021.1916465	PROPN
admet-2874	516	4	https://doi.org/10.1007/s12328-021-01585-2	https://doi.org/10.1007/s12328-021-01585-2	NUM
admet-2874	516	5	https://doi.org/10.1007/s12328-021-01585-2	https://doi.org/10.1007/s12328-021-01585-2	NUM
admet-2874	516	6	https://doi.org/10.1056/nejmoa2309000	https://doi.org/10.1056/nejmoa2309000	PROPN
admet-2874	516	7	https://doi.org/10.1111/liv.15715	https://doi.org/10.1111/liv.15715	NOUN
admet-2874	516	8	https://doi.org/10.1053/j.gastro.2019.11.296	https://doi.org/10.1053/j.gastro.2019.11.296	VERB
admet-2874	517	1	https://doi.org/10.1111/liv.15930	https://doi.org/10.1111/liv.15930	PROPN
admet-2874	517	2	https://doi.org/10.4254/wjh.v15.i2.201	https://doi.org/10.4254/wjh.v15.i2.201	PROPN
admet-2874	517	3	https://doi.org/10.14218/jtg.2024.00040	https://doi.org/10.14218/jtg.2024.00040	NOUN
admet-2874	517	4	https://doi.org/10.1097/hc9.0000000000000612	https://doi.org/10.1097/hc9.0000000000000612	PROPN
admet-2874	517	5	https://doi.org/10.1007/s40265-024-02045-0	https://doi.org/10.1007/s40265-024-02045-0	NUM
admet-2874	517	6	https://doi.org/10.1210/endrev/bnac018	https://doi.org/10.1210/endrev/bnac018	PROPN
admet-2874	517	7	a.	a.	NOUN
admet-2874	517	8	singh	singh	PROPN
admet-2874	517	9	et	et	PROPN
admet-2874	517	10	al	al	PROPN
admet-2874	517	11	.	.	PROPN
admet-2874	517	12	admet	admet	PROPN
admet-2874	517	13	&	&	CCONJ
admet-2874	517	14	dmpk	dmpk	PROPN
admet-2874	517	15	13(4	13(4	NUM
admet-2874	517	16	)	)	PUNCT
admet-2874	517	17	(	(	PUNCT
admet-2874	517	18	2025	2025	NUM
admet-2874	517	19	)	)	PUNCT
admet-2874	517	20	2874	2874	NUM
admet-2874	517	21	20	20	NUM
admet-2874	517	22	64	64	NUM
admet-2874	517	23	.	.	PUNCT
admet-2874	518	1	a.j	a.j	PROPN
admet-2874	518	2	.	.	PROPN
admet-2874	518	3	sanyal	sanyal	PROPN
admet-2874	518	4	,	,	PUNCT
admet-2874	518	5	p.n	p.n	PROPN
admet-2874	518	6	.	.	PROPN
admet-2874	518	7	newsome	newsome	PROPN
admet-2874	518	8	,	,	PUNCT
admet-2874	518	9	i.	i.	PROPN
admet-2874	518	10	kliers	kliers	PROPN
admet-2874	518	11	,	,	PUNCT
admet-2874	518	12	l.h	l.h	PROPN
admet-2874	518	13	.	.	PROPN
admet-2874	518	14	østergaard	østergaard	PROPN
admet-2874	518	15	,	,	PUNCT
admet-2874	518	16	m.t	m.t	PROPN
admet-2874	518	17	.	.	PROPN
admet-2874	518	18	long	long	PROPN
admet-2874	518	19	,	,	PUNCT
admet-2874	518	20	m.s	m.s	PROPN
admet-2874	518	21	.	.	PROPN
admet-2874	518	22	kjær	kjær	PROPN
admet-2874	518	23	,	,	PUNCT
admet-2874	518	24	a.m.g	a.m.g	NOUN
admet-2874	518	25	.	.	PROPN
admet-2874	518	26	cali	cali	PROPN
admet-2874	518	27	,	,	PUNCT
admet-2874	518	28	e.	e.	PROPN
admet-2874	518	29	bugianesi	bugianesi	PROPN
admet-2874	518	30	,	,	PUNCT
admet-2874	518	31	m.e	m.e	PROPN
admet-2874	518	32	.	.	PROPN
admet-2874	518	33	rinella	rinella	PROPN
admet-2874	518	34	,	,	PUNCT
admet-2874	518	35	m.	m.	NOUN
admet-2874	518	36	roden	roden	PROPN
admet-2874	518	37	,	,	PUNCT
admet-2874	518	38	v.	v.	ADP
admet-2874	518	39	ratziu	ratziu	NOUN
admet-2874	518	40	.	.	PUNCT
admet-2874	519	1	phase	phase	NOUN
admet-2874	519	2	3	3	NUM
admet-2874	519	3	trial	trial	NOUN
admet-2874	519	4	of	of	ADP
admet-2874	519	5	semaglutide	semaglutide	NOUN
admet-2874	519	6	in	in	ADP
admet-2874	519	7	metabolic	metabolic	ADJ
admet-2874	519	8	dysfunction	dysfunction	NOUN
admet-2874	519	9	-	-	PUNCT
admet-2874	519	10	associated	associate	VERB
admet-2874	519	11	steatohepatitis	steatohepatitis	NOUN
admet-2874	519	12	.	.	PUNCT
admet-2874	520	1	new	new	PROPN
admet-2874	520	2	england	england	PROPN
admet-2874	520	3	journal	journal	PROPN
admet-2874	520	4	of	of	ADP
admet-2874	520	5	medicine	medicine	NOUN
admet-2874	520	6	392	392	NUM
admet-2874	520	7	(	(	PUNCT
admet-2874	520	8	2025	2025	NUM
admet-2874	520	9	)	)	PUNCT
admet-2874	520	10	20892099	20892099	NUM
admet-2874	520	11	.	.	PUNCT
admet-2874	521	1	https://doi.org/10.1056/nejmoa2413258	https://doi.org/10.1056/nejmoa2413258	PROPN
admet-2874	521	2	65	65	NUM
admet-2874	521	3	.	.	PUNCT
admet-2874	522	1	a.	a.	PROPN
admet-2874	522	2	azizsoltani	azizsoltani	PROPN
admet-2874	522	3	,	,	PUNCT
admet-2874	522	4	b.	b.	PROPN
admet-2874	522	5	niknam	niknam	PROPN
admet-2874	522	6	,	,	PUNCT
admet-2874	522	7	m.	m.	NOUN
admet-2874	522	8	taghizadeh	taghizadeh	PROPN
admet-2874	522	9	-	-	PUNCT
admet-2874	522	10	teymorloei	teymorloei	PROPN
admet-2874	522	11	,	,	PUNCT
admet-2874	522	12	e.	e.	PROPN
admet-2874	522	13	ghoodjani	ghoodjani	PROPN
admet-2874	522	14	,	,	PUNCT
admet-2874	522	15	h.	h.	PROPN
admet-2874	522	16	dianat	dianat	PROPN
admet-2874	522	17	-	-	PUNCT
admet-2874	522	18	moghadam	moghadam	PROPN
admet-2874	522	19	,	,	PUNCT
admet-2874	522	20	e.	e.	PROPN
admet-2874	522	21	alizadeh	alizadeh	PROPN
admet-2874	522	22	.	.	PUNCT
admet-2874	523	1	therapeutic	therapeutic	ADJ
admet-2874	523	2	implications	implication	NOUN
admet-2874	523	3	of	of	ADP
admet-2874	523	4	obeticholic	obeticholic	ADJ
admet-2874	523	5	acid	acid	NOUN
admet-2874	523	6	,	,	PUNCT
admet-2874	523	7	a	a	DET
admet-2874	523	8	farnesoid	farnesoid	NOUN
admet-2874	523	9	x	x	SYM
admet-2874	523	10	receptor	receptor	NOUN
admet-2874	523	11	agonist	agonist	NOUN
admet-2874	523	12	,	,	PUNCT
admet-2874	523	13	in	in	ADP
admet-2874	523	14	the	the	DET
admet-2874	523	15	treatment	treatment	NOUN
admet-2874	523	16	of	of	ADP
admet-2874	523	17	liver	liver	NOUN
admet-2874	523	18	fibrosis	fibrosis	NOUN
admet-2874	523	19	.	.	PUNCT
admet-2874	524	1	biomedicine	biomedicine	NOUN
admet-2874	524	2	pharmacotherapy	pharmacotherapy	NOUN
admet-2874	524	3	189	189	NUM
admet-2874	524	4	(	(	PUNCT
admet-2874	524	5	2025	2025	NUM
admet-2874	524	6	)	)	PUNCT
admet-2874	524	7	11829	11829	NUM
admet-2874	524	8	.	.	PUNCT
admet-2874	525	1	https://doi.org/10.1016/j.biopha.2025.118249	https://doi.org/10.1016/j.biopha.2025.118249	PROPN
admet-2874	525	2	66	66	NUM
admet-2874	525	3	.	.	PUNCT
admet-2874	526	1	v.j	v.j	PROPN
admet-2874	526	2	.	.	PROPN
admet-2874	526	3	thannickal	thannickal	PROPN
admet-2874	526	4	,	,	PUNCT
admet-2874	526	5	k.	k.	PROPN
admet-2874	526	6	jandeleit	jandeleit	PROPN
admet-2874	526	7	-	-	PUNCT
admet-2874	526	8	dahm	dahm	PROPN
admet-2874	526	9	,	,	PUNCT
admet-2874	526	10	c.	c.	PROPN
admet-2874	526	11	szyndralewiez	szyndralewiez	PROPN
admet-2874	526	12	,	,	PUNCT
admet-2874	526	13	n.j	n.j	PROPN
admet-2874	526	14	.	.	PROPN
admet-2874	526	15	török	török	PROPN
admet-2874	526	16	.	.	PUNCT
admet-2874	527	1	pre	pre	ADJ
admet-2874	527	2	-	-	ADJ
admet-2874	527	3	clinical	clinical	ADJ
admet-2874	527	4	evidence	evidence	NOUN
admet-2874	527	5	of	of	ADP
admet-2874	527	6	a	a	DET
admet-2874	527	7	dual	dual	ADJ
admet-2874	527	8	nadph	nadph	ADJ
admet-2874	527	9	oxidase	oxidase	NOUN
admet-2874	527	10	1/4	1/4	NUM
admet-2874	527	11	inhibitor	inhibitor	NOUN
admet-2874	527	12	(	(	PUNCT
admet-2874	527	13	setanaxib	setanaxib	NOUN
admet-2874	527	14	)	)	PUNCT
admet-2874	527	15	in	in	ADP
admet-2874	527	16	liver	liver	NOUN
admet-2874	527	17	,	,	PUNCT
admet-2874	527	18	kidney	kidney	NOUN
admet-2874	527	19	and	and	CCONJ
admet-2874	527	20	lung	lung	NOUN
admet-2874	527	21	fibrosis	fibrosis	NOUN
admet-2874	527	22	.	.	PUNCT
admet-2874	528	1	journal	journal	NOUN
admet-2874	528	2	of	of	ADP
admet-2874	528	3	cellular	cellular	ADJ
admet-2874	528	4	and	and	CCONJ
admet-2874	528	5	molecular	molecular	ADJ
admet-2874	528	6	medicine	medicine	NOUN
admet-2874	528	7	27	27	NUM
admet-2874	528	8	(	(	PUNCT
admet-2874	528	9	2023	2023	NUM
admet-2874	528	10	)	)	PUNCT
admet-2874	528	11	471	471	NUM
admet-2874	528	12	-	-	SYM
admet-2874	528	13	481	481	NUM
admet-2874	528	14	.	.	PUNCT
admet-2874	529	1	https://doi.org/10.1111/jcmm.17649	https://doi.org/10.1111/jcmm.17649	ADJ
admet-2874	529	2	67	67	NUM
admet-2874	529	3	.	.	PUNCT
admet-2874	530	1	s.m	s.m	PROPN
admet-2874	530	2	.	.	PROPN
admet-2874	531	1	el	el	PROPN
admet-2874	531	2	-	-	PUNCT
admet-2874	531	3	haggar	haggar	PROPN
admet-2874	531	4	,	,	PUNCT
admet-2874	531	5	s.k	s.k	PROPN
admet-2874	531	6	.	.	PROPN
admet-2874	531	7	hegazy	hegazy	PROPN
admet-2874	531	8	,	,	PUNCT
admet-2874	531	9	s.m	s.m	PROPN
admet-2874	531	10	.	.	PROPN
admet-2874	531	11	abd	abd	PROPN
admet-2874	531	12	-	-	PUNCT
admet-2874	531	13	elsalam	elsalam	PROPN
admet-2874	531	14	,	,	PUNCT
admet-2874	531	15	m.m	m.m	PROPN
admet-2874	531	16	.	.	PROPN
admet-2874	531	17	bahaa	bahaa	PROPN
admet-2874	531	18	.	.	PUNCT
admet-2874	532	1	pentoxifylline	pentoxifylline	PROPN
admet-2874	532	2	,	,	PUNCT
admet-2874	532	3	a	a	DET
admet-2874	532	4	nonselective	nonselective	ADJ
admet-2874	532	5	phosphodiesterase	phosphodiesterase	NOUN
admet-2874	532	6	inhibitor	inhibitor	NOUN
admet-2874	532	7	,	,	PUNCT
admet-2874	532	8	in	in	ADP
admet-2874	532	9	adjunctive	adjunctive	ADJ
admet-2874	532	10	therapy	therapy	NOUN
admet-2874	532	11	in	in	ADP
admet-2874	532	12	patients	patient	NOUN
admet-2874	532	13	with	with	ADP
admet-2874	532	14	irritable	irritable	ADJ
admet-2874	532	15	bowel	bowel	NOUN
admet-2874	532	16	syndrome	syndrome	NOUN
admet-2874	532	17	treated	treat	VERB
admet-2874	532	18	with	with	ADP
admet-2874	532	19	mebeverine	mebeverine	NOUN
admet-2874	532	20	.	.	PUNCT
admet-2874	533	1	biomedicine	biomedicine	NOUN
admet-2874	533	2	pharmacotherapy	pharmacotherapy	NOUN
admet-2874	533	3	145	145	NUM
admet-2874	533	4	(	(	PUNCT
admet-2874	533	5	2022	2022	NUM
admet-2874	533	6	)	)	PUNCT
admet-2874	533	7	112399	112399	NUM
admet-2874	533	8	.	.	PUNCT
admet-2874	534	1	https://doi.org/10.1016/j.biopha.2021.112399	https://doi.org/10.1016/j.biopha.2021.112399	PROPN
admet-2874	534	2	68	68	NUM
admet-2874	534	3	.	.	PUNCT
admet-2874	534	4	x.	x.	PROPN
admet-2874	534	5	cai	cai	PROPN
admet-2874	534	6	,	,	PUNCT
admet-2874	534	7	x.	x.	PROPN
admet-2874	534	8	liu	liu	PROPN
admet-2874	534	9	,	,	PUNCT
admet-2874	534	10	w.	w.	PROPN
admet-2874	534	11	xie	xie	PROPN
admet-2874	534	12	,	,	PUNCT
admet-2874	534	13	a.	a.	PROPN
admet-2874	534	14	ma	ma	PROPN
admet-2874	534	15	,	,	PUNCT
admet-2874	534	16	y.	y.	PROPN
admet-2874	534	17	tan	tan	PROPN
admet-2874	534	18	,	,	PUNCT
admet-2874	534	19	j.	j.	PROPN
admet-2874	534	20	shang	shang	PROPN
admet-2874	534	21	,	,	PUNCT
admet-2874	534	22	j.	j.	PROPN
admet-2874	534	23	zhang	zhang	PROPN
admet-2874	534	24	,	,	PUNCT
admet-2874	534	25	c.	c.	PROPN
admet-2874	534	26	chen	chen	PROPN
admet-2874	534	27	,	,	PUNCT
admet-2874	534	28	y.	y.	PROPN
admet-2874	534	29	yu	yu	PROPN
admet-2874	534	30	,	,	PUNCT
admet-2874	534	31	y.	y.	PROPN
admet-2874	534	32	qu	qu	PROPN
admet-2874	534	33	,	,	PUNCT
admet-2874	534	34	l.	l.	PROPN
admet-2874	534	35	zhang	zhang	PROPN
admet-2874	534	36	,	,	PUNCT
admet-2874	534	37	y.	y.	PROPN
admet-2874	534	38	luo	luo	PROPN
admet-2874	534	39	,	,	PUNCT
admet-2874	534	40	p.	p.	PROPN
admet-2874	534	41	yin	yin	PROPN
admet-2874	534	42	,	,	PUNCT
admet-2874	534	43	j.	j.	PROPN
admet-2874	534	44	cheng	cheng	PROPN
admet-2874	534	45	,	,	PUNCT
admet-2874	534	46	l.	l.	PROPN
admet-2874	534	47	lu	lu	PROPN
admet-2874	534	48	.	.	PUNCT
admet-2874	535	1	hydronidone	hydronidone	PROPN
admet-2874	535	2	for	for	ADP
admet-2874	535	3	the	the	DET
admet-2874	535	4	treatment	treatment	NOUN
admet-2874	535	5	of	of	ADP
admet-2874	535	6	liver	liver	NOUN
admet-2874	535	7	fibrosis	fibrosis	NOUN
admet-2874	535	8	related	relate	VERB
admet-2874	535	9	to	to	ADP
admet-2874	535	10	chronic	chronic	ADJ
admet-2874	535	11	hepatitis	hepatitis	NOUN
admet-2874	535	12	b	b	NOUN
admet-2874	535	13	:	:	PUNCT
admet-2874	535	14	a	a	DET
admet-2874	535	15	phase	phase	NOUN
admet-2874	535	16	2	2	NUM
admet-2874	535	17	randomized	randomize	VERB
admet-2874	535	18	controlled	control	VERB
admet-2874	535	19	trial	trial	NOUN
admet-2874	535	20	.	.	PUNCT
admet-2874	536	1	clinical	clinical	ADJ
admet-2874	536	2	gastroenterology	gastroenterology	NOUN
admet-2874	536	3	and	and	CCONJ
admet-2874	536	4	hepatology	hepatology	NOUN
admet-2874	536	5	21	21	NUM
admet-2874	536	6	(	(	PUNCT
admet-2874	536	7	2023	2023	NUM
admet-2874	536	8	)	)	PUNCT
admet-2874	536	9	1893	1893	NUM
admet-2874	536	10	-	-	SYM
admet-2874	536	11	1901.e7	1901.e7	PROPN
admet-2874	536	12	.	.	PUNCT
admet-2874	537	1	https://doi.org/10.1016/j.cgh.2022.05.056	https://doi.org/10.1016/j.cgh.2022.05.056	NOUN
admet-2874	537	2	69	69	NUM
admet-2874	537	3	.	.	PUNCT
admet-2874	538	1	j.	j.	PROPN
admet-2874	538	2	zhang	zhang	PROPN
admet-2874	538	3	,	,	PUNCT
admet-2874	538	4	q.	q.	PROPN
admet-2874	538	5	wang	wang	PROPN
admet-2874	538	6	,	,	PUNCT
admet-2874	538	7	n.	n.	PROPN
admet-2874	538	8	zhou	zhou	PROPN
admet-2874	538	9	,	,	PUNCT
admet-2874	538	10	j.	j.	PROPN
admet-2874	538	11	liu	liu	PROPN
admet-2874	538	12	,	,	PUNCT
admet-2874	538	13	l.	l.	PROPN
admet-2874	538	14	tao	tao	PROPN
admet-2874	538	15	,	,	PUNCT
admet-2874	538	16	z.	z.	PROPN
admet-2874	538	17	peng	peng	PROPN
admet-2874	538	18	,	,	PUNCT
admet-2874	538	19	g.	g.	PROPN
admet-2874	538	20	hu	hu	PROPN
admet-2874	538	21	,	,	PUNCT
admet-2874	538	22	h.	h.	PROPN
admet-2874	538	23	wang	wang	PROPN
admet-2874	538	24	,	,	PUNCT
admet-2874	538	25	l.	l.	PROPN
admet-2874	538	26	fu	fu	PROPN
admet-2874	538	27	,	,	PUNCT
admet-2874	538	28	s.	s.	PROPN
admet-2874	538	29	peng	peng	PROPN
admet-2874	538	30	.	.	PUNCT
admet-2874	539	1	fluorofenidone	fluorofenidone	NOUN
admet-2874	539	2	attenuates	attenuate	VERB
admet-2874	539	3	choline	choline	NOUN
admet-2874	539	4	-	-	PUNCT
admet-2874	539	5	deficient	deficient	ADJ
admet-2874	539	6	,	,	PUNCT
admet-2874	539	7	l	l	ADJ
admet-2874	539	8	-	-	ADJ
admet-2874	539	9	amino	amino	ADJ
admet-2874	539	10	acid	acid	NOUN
admet-2874	539	11	-	-	PUNCT
admet-2874	539	12	defined	define	VERB
admet-2874	539	13	,	,	PUNCT
admet-2874	539	14	high	high	ADJ
admet-2874	539	15	-	-	PUNCT
admet-2874	539	16	fat	fat	NOUN
admet-2874	539	17	diet	diet	NOUN
admet-2874	539	18	-	-	PUNCT
admet-2874	539	19	induced	induce	VERB
admet-2874	539	20	metabolic	metabolic	NOUN
admet-2874	539	21	dysfunction	dysfunction	NOUN
admet-2874	539	22	-	-	PUNCT
admet-2874	539	23	associated	associate	VERB
admet-2874	539	24	steatohepatitis	steatohepatitis	NOUN
admet-2874	539	25	in	in	ADP
admet-2874	539	26	mice	mouse	NOUN
admet-2874	539	27	.	.	PUNCT
admet-2874	540	1	scientific	scientific	ADJ
admet-2874	540	2	reports	report	NOUN
admet-2874	540	3	15	15	NUM
admet-2874	540	4	(	(	PUNCT
admet-2874	540	5	2025	2025	NUM
admet-2874	540	6	)	)	PUNCT
admet-2874	540	7	9863	9863	NUM
admet-2874	540	8	.	.	PUNCT
admet-2874	541	1	https://doi.org/10.1038/s41598-025-94401-7	https://doi.org/10.1038/s41598-025-94401-7	NUM
admet-2874	542	1	70	70	NUM
admet-2874	542	2	.	.	PUNCT
admet-2874	543	1	z.	z.	PROPN
admet-2874	543	2	ma	ma	PROPN
admet-2874	543	3	,	,	PUNCT
admet-2874	543	4	k.	k.	PROPN
admet-2874	543	5	jin	jin	PROPN
admet-2874	543	6	,	,	PUNCT
admet-2874	543	7	m.	m.	PROPN
admet-2874	543	8	yue	yue	PROPN
admet-2874	543	9	,	,	PUNCT
admet-2874	543	10	x.	x.	PROPN
admet-2874	543	11	chen	chen	PROPN
admet-2874	543	12	,	,	PUNCT
admet-2874	543	13	j.	j.	PROPN
admet-2874	543	14	chen	chen	PROPN
admet-2874	543	15	.	.	PUNCT
admet-2874	544	1	research	research	NOUN
admet-2874	544	2	progress	progress	NOUN
admet-2874	544	3	on	on	ADP
admet-2874	544	4	the	the	DET
admet-2874	544	5	gip	gip	NOUN
admet-2874	544	6	/	/	SYM
admet-2874	544	7	glp-1	glp-1	NOUN
admet-2874	544	8	receptor	receptor	NOUN
admet-2874	544	9	coagonist	coagonist	NOUN
admet-2874	544	10	tirzepatide	tirzepatide	ADV
admet-2874	544	11	,	,	PUNCT
admet-2874	544	12	a	a	DET
admet-2874	544	13	rising	rise	VERB
admet-2874	544	14	star	star	NOUN
admet-2874	544	15	in	in	ADP
admet-2874	544	16	type	type	NOUN
admet-2874	544	17	2	2	NUM
admet-2874	544	18	diabetes	diabetes	NOUN
admet-2874	544	19	.	.	PUNCT
admet-2874	545	1	journal	journal	NOUN
admet-2874	545	2	of	of	ADP
admet-2874	545	3	diabetes	diabetes	NOUN
admet-2874	545	4	research	research	NOUN
admet-2874	545	5	2023	2023	NUM
admet-2874	545	6	(	(	PUNCT
admet-2874	545	7	2023	2023	NUM
admet-2874	545	8	)	)	PUNCT
admet-2874	545	9	5891532	5891532	NUM
admet-2874	545	10	.	.	PUNCT
admet-2874	546	1	https://doi.org/10.1155/2023/5891532	https://doi.org/10.1155/2023/5891532	NOUN
admet-2874	546	2	71	71	NUM
admet-2874	546	3	.	.	PUNCT
admet-2874	547	1	n.	n.	PROPN
admet-2874	547	2	alkhouri	alkhouri	PROPN
admet-2874	547	3	,	,	PUNCT
admet-2874	547	4	e.	e.	PROPN
admet-2874	547	5	lawitz	lawitz	PROPN
admet-2874	547	6	,	,	PUNCT
admet-2874	547	7	m.	m.	NOUN
admet-2874	547	8	noureddin	noureddin	PROPN
admet-2874	547	9	,	,	PUNCT
admet-2874	547	10	r.	r.	NOUN
admet-2874	547	11	defronzo	defronzo	PROPN
admet-2874	547	12	,	,	PUNCT
admet-2874	547	13	g.i	g.i	PROPN
admet-2874	547	14	.	.	PROPN
admet-2874	547	15	shulman	shulman	PROPN
admet-2874	547	16	.	.	PUNCT
admet-2874	548	1	gs-0976	gs-0976	PROPN
admet-2874	548	2	(	(	PUNCT
admet-2874	548	3	firsocostat	firsocostat	PROPN
admet-2874	548	4	):	):	PUNCT
admet-2874	548	5	an	an	DET
admet-2874	548	6	investigational	investigational	ADJ
admet-2874	548	7	liver	liver	NOUN
admet-2874	548	8	-	-	PUNCT
admet-2874	548	9	directed	direct	VERB
admet-2874	548	10	acetyl	acetyl	NOUN
admet-2874	548	11	-	-	PUNCT
admet-2874	548	12	coa	coa	NOUN
admet-2874	548	13	carboxylase	carboxylase	NOUN
admet-2874	548	14	(	(	PUNCT
admet-2874	548	15	acc	acc	PROPN
admet-2874	548	16	)	)	PUNCT
admet-2874	548	17	inhibitor	inhibitor	NOUN
admet-2874	548	18	for	for	ADP
admet-2874	548	19	the	the	DET
admet-2874	548	20	treatment	treatment	NOUN
admet-2874	548	21	of	of	ADP
admet-2874	548	22	non	non	ADJ
admet-2874	548	23	-	-	ADJ
admet-2874	548	24	alcoholic	alcoholic	ADJ
admet-2874	548	25	steatohepatitis	steatohepatitis	NOUN
admet-2874	548	26	(	(	PUNCT
admet-2874	548	27	nash	nash	PROPN
admet-2874	548	28	)	)	PUNCT
admet-2874	548	29	.	.	PUNCT
admet-2874	549	1	expert	expert	ADJ
admet-2874	549	2	opinion	opinion	NOUN
admet-2874	549	3	on	on	ADP
admet-2874	549	4	investigational	investigational	ADJ
admet-2874	549	5	drugs	drug	NOUN
admet-2874	549	6	29	29	NUM
admet-2874	549	7	(	(	PUNCT
admet-2874	549	8	2020	2020	NUM
admet-2874	549	9	)	)	PUNCT
admet-2874	549	10	135141	135141	NUM
admet-2874	549	11	.	.	PUNCT
admet-2874	550	1	https://doi.org/10.1080/13543784.2020.1668374	https://doi.org/10.1080/13543784.2020.1668374	X
admet-2874	551	1	72	72	NUM
admet-2874	551	2	.	.	PUNCT
admet-2874	552	1	r.	r.	PROPN
admet-2874	552	2	loomba	loomba	PROPN
admet-2874	552	3	,	,	PUNCT
admet-2874	552	4	a.j	a.j	PROPN
admet-2874	552	5	.	.	PROPN
admet-2874	552	6	sanyal	sanyal	PROPN
admet-2874	552	7	,	,	PUNCT
admet-2874	552	8	a.	a.	PROPN
admet-2874	552	9	nakajima	nakajima	PROPN
admet-2874	552	10	,	,	PUNCT
admet-2874	552	11	b.a	b.a	PROPN
admet-2874	552	12	.	.	PROPN
admet-2874	552	13	neuschwander	neuschwander	PROPN
admet-2874	552	14	-	-	PUNCT
admet-2874	552	15	tetri	tetri	PROPN
admet-2874	552	16	,	,	PUNCT
admet-2874	552	17	z.d	z.d	PROPN
admet-2874	552	18	.	.	PROPN
admet-2874	552	19	goodman	goodman	PROPN
admet-2874	552	20	,	,	PUNCT
admet-2874	552	21	s.a	s.a	PROPN
admet-2874	552	22	.	.	PROPN
admet-2874	552	23	harrison	harrison	PROPN
admet-2874	552	24	,	,	PUNCT
admet-2874	552	25	e.j	e.j	PROPN
admet-2874	552	26	.	.	PROPN
admet-2874	552	27	lawitz	lawitz	PROPN
admet-2874	552	28	,	,	PUNCT
admet-2874	552	29	n.	n.	PROPN
admet-2874	552	30	gunn	gunn	PROPN
admet-2874	552	31	,	,	PUNCT
admet-2874	552	32	k.	k.	PROPN
admet-2874	552	33	imajo	imajo	PROPN
admet-2874	552	34	,	,	PUNCT
admet-2874	552	35	n.	n.	PROPN
admet-2874	552	36	ravendhran	ravendhran	PROPN
admet-2874	552	37	,	,	PUNCT
admet-2874	552	38	t.	t.	PROPN
admet-2874	552	39	akahane	akahane	PROPN
admet-2874	552	40	,	,	PUNCT
admet-2874	552	41	b.	b.	PROPN
admet-2874	552	42	boone	boone	PROPN
admet-2874	552	43	,	,	PUNCT
admet-2874	552	44	m.	m.	PROPN
admet-2874	552	45	yamaguchi	yamaguchi	PROPN
admet-2874	552	46	,	,	PUNCT
admet-2874	552	47	a.	a.	PROPN
admet-2874	552	48	chatterjee	chatterjee	PROPN
admet-2874	552	49	,	,	PUNCT
admet-2874	552	50	g.s	g.s	PROPN
admet-2874	552	51	.	.	PROPN
admet-2874	552	52	tirucherai	tirucherai	PROPN
admet-2874	552	53	,	,	PUNCT
admet-2874	552	54	d.e	d.e	PROPN
admet-2874	552	55	.	.	PROPN
admet-2874	552	56	shevell	shevell	PROPN
admet-2874	552	57	,	,	PUNCT
admet-2874	552	58	s.	s.	PROPN
admet-2874	552	59	du	du	PROPN
admet-2874	552	60	,	,	PUNCT
admet-2874	552	61	e.d	e.d	PROPN
admet-2874	552	62	.	.	PROPN
admet-2874	552	63	charles	charles	PROPN
admet-2874	552	64	,	,	PUNCT
admet-2874	552	65	m.f	m.f	PROPN
admet-2874	552	66	.	.	PROPN
admet-2874	552	67	abdelmalek	abdelmalek	PROPN
admet-2874	552	68	.	.	PUNCT
admet-2874	553	1	pegbelfermin	pegbelfermin	NOUN
admet-2874	553	2	in	in	ADP
admet-2874	553	3	patients	patient	NOUN
admet-2874	553	4	with	with	ADP
admet-2874	553	5	nonalcoholic	nonalcoholic	PROPN
admet-2874	553	6	steatohepatitis	steatohepatitis	NOUN
admet-2874	553	7	and	and	CCONJ
admet-2874	553	8	stage	stage	NOUN
admet-2874	553	9	3	3	NUM
admet-2874	553	10	fibrosis	fibrosis	NOUN
admet-2874	553	11	(	(	PUNCT
admet-2874	553	12	falcon	falcon	PROPN
admet-2874	553	13	1	1	NUM
admet-2874	553	14	):	):	PUNCT
admet-2874	553	15	a	a	DET
admet-2874	553	16	randomized	randomized	ADJ
admet-2874	553	17	phase	phase	NOUN
admet-2874	553	18	2b	2b	NUM
admet-2874	553	19	study	study	NOUN
admet-2874	553	20	.	.	PUNCT
admet-2874	554	1	clinical	clinical	ADJ
admet-2874	554	2	gastroenterology	gastroenterology	NOUN
admet-2874	554	3	and	and	CCONJ
admet-2874	554	4	hepatology	hepatology	NOUN
admet-2874	554	5	22	22	NUM
admet-2874	554	6	(	(	PUNCT
admet-2874	554	7	2024	2024	NUM
admet-2874	554	8	)	)	PUNCT
admet-2874	554	9	102112.e9	102112.e9	NOUN
admet-2874	554	10	.	.	PUNCT
admet-2874	555	1	https://doi.org/10.1016/j.cgh.2023.04.011	https://doi.org/10.1016/j.cgh.2023.04.011	NOUN
admet-2874	555	2	73	73	NUM
admet-2874	555	3	.	.	PUNCT
admet-2874	556	1	m.e	m.e	PROPN
admet-2874	556	2	.	.	PROPN
admet-2874	556	3	rinella	rinella	PROPN
admet-2874	556	4	,	,	PUNCT
admet-2874	556	5	h.d	h.d	PROPN
admet-2874	556	6	.	.	PROPN
admet-2874	556	7	lieu	lieu	PROPN
admet-2874	556	8	,	,	PUNCT
admet-2874	556	9	k.v	k.v	PROPN
admet-2874	556	10	.	.	PROPN
admet-2874	556	11	kowdley	kowdley	PROPN
admet-2874	556	12	,	,	PUNCT
admet-2874	556	13	z.d	z.d	PROPN
admet-2874	556	14	.	.	PROPN
admet-2874	556	15	goodman	goodman	PROPN
admet-2874	556	16	,	,	PUNCT
admet-2874	556	17	n.	n.	PROPN
admet-2874	556	18	alkhouri	alkhouri	PROPN
admet-2874	556	19	,	,	PUNCT
admet-2874	556	20	e.	e.	PROPN
admet-2874	556	21	lawitz	lawitz	PROPN
admet-2874	556	22	,	,	PUNCT
admet-2874	556	23	v.	v.	ADP
admet-2874	556	24	ratziu	ratziu	PROPN
admet-2874	556	25	,	,	PUNCT
admet-2874	556	26	m.f	m.f	PROPN
admet-2874	556	27	.	.	PROPN
admet-2874	556	28	abdelmalek	abdelmalek	PROPN
admet-2874	556	29	,	,	PUNCT
admet-2874	556	30	v.w.s	v.w.s	PROPN
admet-2874	556	31	.	.	PUNCT
admet-2874	557	1	wong	wong	PROPN
admet-2874	557	2	,	,	PUNCT
admet-2874	557	3	z.h	z.h	PROPN
admet-2874	557	4	.	.	PROPN
admet-2874	557	5	younes	younes	PROPN
admet-2874	557	6	,	,	PUNCT
admet-2874	557	7	a.m.	a.m.	PROPN
admet-2874	557	8	sheikh	sheikh	PROPN
admet-2874	557	9	,	,	PUNCT
admet-2874	557	10	d.	d.	PROPN
admet-2874	557	11	brannan	brannan	PROPN
admet-2874	557	12	,	,	PUNCT
admet-2874	557	13	b.	b.	PROPN
admet-2874	557	14	freilich	freilich	PROPN
admet-2874	557	15	,	,	PUNCT
admet-2874	557	16	f.	f.	PROPN
admet-2874	557	17	membreno	membreno	PROPN
admet-2874	557	18	,	,	PUNCT
admet-2874	557	19	m.	m.	NOUN
admet-2874	557	20	sinclair	sinclair	PROPN
admet-2874	557	21	,	,	PUNCT
admet-2874	557	22	l.	l.	PROPN
admet-2874	557	23	melchor	melchor	PROPN
admet-2874	557	24	-	-	PUNCT
admet-2874	557	25	khan	khan	PROPN
admet-2874	557	26	,	,	PUNCT
admet-2874	557	27	a.j	a.j	PROPN
admet-2874	557	28	.	.	PROPN
admet-2874	557	29	sanyal	sanyal	PROPN
admet-2874	557	30	,	,	PUNCT
admet-2874	557	31	l.	l.	PROPN
admet-2874	557	32	ling	ling	PROPN
admet-2874	557	33	,	,	PUNCT
admet-2874	557	34	s.a	s.a	PROPN
admet-2874	557	35	.	.	PROPN
admet-2874	557	36	harrison	harrison	PROPN
admet-2874	557	37	.	.	PUNCT
admet-2874	558	1	a	a	DET
admet-2874	558	2	randomized	randomized	ADJ
admet-2874	558	3	,	,	PUNCT
admet-2874	558	4	double	double	ADJ
admet-2874	558	5	-	-	PUNCT
admet-2874	558	6	blind	blind	ADJ
admet-2874	558	7	,	,	PUNCT
admet-2874	558	8	placebo	placebo	NOUN
admet-2874	558	9	-	-	PUNCT
admet-2874	558	10	controlled	control	VERB
admet-2874	558	11	trial	trial	NOUN
admet-2874	558	12	of	of	ADP
admet-2874	558	13	aldafermin	aldafermin	NOUN
admet-2874	558	14	in	in	ADP
admet-2874	558	15	patients	patient	NOUN
admet-2874	558	16	with	with	ADP
admet-2874	558	17	nash	nash	NOUN
admet-2874	558	18	and	and	CCONJ
admet-2874	558	19	compensated	compensated	ADJ
admet-2874	558	20	cirrhosis	cirrhosis	NOUN
admet-2874	558	21	.	.	PUNCT
admet-2874	559	1	hepatology	hepatology	NOUN
admet-2874	559	2	79	79	NUM
admet-2874	559	3	(	(	PUNCT
admet-2874	559	4	2024	2024	NUM
admet-2874	559	5	)	)	PUNCT
admet-2874	559	6	674	674	NUM
admet-2874	559	7	-	-	SYM
admet-2874	559	8	689	689	NUM
admet-2874	559	9	.	.	PUNCT
admet-2874	560	1	https://doi.org/10.1097/hep.0000000000000607	https://doi.org/10.1097/hep.0000000000000607	PROPN
admet-2874	560	2	74	74	NUM
admet-2874	560	3	.	.	PUNCT
admet-2874	561	1	v.	v.	ADP
admet-2874	561	2	ratziu	ratziu	NOUN
admet-2874	561	3	,	,	PUNCT
admet-2874	561	4	y.	y.	PROPN
admet-2874	561	5	yilmaz	yilmaz	PROPN
admet-2874	561	6	,	,	PUNCT
admet-2874	561	7	d.	d.	PROPN
admet-2874	561	8	lazas	lazas	PROPN
admet-2874	561	9	,	,	PUNCT
admet-2874	561	10	s.l	s.l	PROPN
admet-2874	561	11	.	.	PROPN
admet-2874	561	12	friedman	friedman	PROPN
admet-2874	561	13	,	,	PUNCT
admet-2874	561	14	c.	c.	PROPN
admet-2874	561	15	lackner	lackner	PROPN
admet-2874	561	16	,	,	PUNCT
admet-2874	561	17	c.	c.	PROPN
admet-2874	561	18	behling	behling	NOUN
admet-2874	561	19	,	,	PUNCT
admet-2874	561	20	o.w	o.w	PROPN
admet-2874	561	21	.	.	PROPN
admet-2874	561	22	cummings	cummings	PROPN
admet-2874	561	23	,	,	PUNCT
admet-2874	561	24	l.	l.	PROPN
admet-2874	561	25	chen	chen	PROPN
admet-2874	561	26	,	,	PUNCT
admet-2874	561	27	m.	m.	NOUN
admet-2874	561	28	petitjean	petitjean	NOUN
admet-2874	561	29	,	,	PUNCT
admet-2874	561	30	y.	y.	PROPN
admet-2874	561	31	gilgun	gilgun	PROPN
admet-2874	561	32	-	-	PUNCT
admet-2874	561	33	sherki	sherki	NOUN
admet-2874	561	34	,	,	PUNCT
admet-2874	561	35	t.	t.	PROPN
admet-2874	561	36	gorfine	gorfine	PROPN
admet-2874	561	37	,	,	PUNCT
admet-2874	561	38	s.	s.	PROPN
admet-2874	561	39	kadosh	kadosh	PROPN
admet-2874	561	40	,	,	PUNCT
admet-2874	561	41	e.	e.	PROPN
admet-2874	561	42	eyal	eyal	PROPN
admet-2874	561	43	,	,	PUNCT
admet-2874	561	44	a.j	a.j	PROPN
admet-2874	561	45	.	.	PROPN
admet-2874	561	46	sanyal	sanyal	PROPN
admet-2874	561	47	.	.	PROPN
admet-2874	561	48	aramchol	aramchol	NOUN
admet-2874	561	49	improves	improve	VERB
admet-2874	561	50	hepatic	hepatic	ADJ
admet-2874	561	51	fibrosis	fibrosis	NOUN
admet-2874	561	52	in	in	ADP
admet-2874	561	53	metabolic	metabolic	NOUN
admet-2874	561	54	dysfunction	dysfunction	NOUN
admet-2874	561	55	-	-	PUNCT
admet-2874	561	56	associated	associate	VERB
admet-2874	561	57	steatohepatitis	steatohepatitis	NOUN
admet-2874	561	58	:	:	PUNCT
admet-2874	561	59	results	result	NOUN
admet-2874	561	60	of	of	ADP
admet-2874	561	61	multimodality	multimodality	NOUN
admet-2874	561	62	assessment	assessment	NOUN
admet-2874	561	63	using	use	VERB
admet-2874	561	64	both	both	CCONJ
admet-2874	561	65	conventional	conventional	ADJ
admet-2874	561	66	and	and	CCONJ
admet-2874	561	67	digital	digital	ADJ
admet-2874	561	68	pathology	pathology	NOUN
admet-2874	561	69	.	.	PUNCT
admet-2874	562	1	hepatology	hepatology	NOUN
admet-2874	562	2	81	81	NUM
admet-2874	562	3	(	(	PUNCT
admet-2874	562	4	2025	2025	NUM
admet-2874	562	5	)	)	PUNCT
admet-2874	562	6	932	932	NUM
admet-2874	562	7	.	.	PUNCT
admet-2874	563	1	https://doi.org/10.1097/hep.0000000000000980	https://doi.org/10.1097/hep.0000000000000980	ADJ
admet-2874	563	2	75	75	NUM
admet-2874	563	3	.	.	PUNCT
admet-2874	564	1	f.	f.	PROPN
admet-2874	564	2	ciftci	ciftci	PROPN
admet-2874	564	3	,	,	PUNCT
admet-2874	564	4	a.c	a.c	PROPN
admet-2874	564	5	.	.	PROPN
admet-2874	564	6	özarslan	özarslan	PROPN
admet-2874	564	7	,	,	PUNCT
admet-2874	564	8	i̇.c	i̇.c	PROPN
admet-2874	564	9	.	.	PUNCT
admet-2874	565	1	kantarci	kantarci	PROPN
admet-2874	565	2	,	,	PUNCT
admet-2874	565	3	a.	a.	NOUN
admet-2874	565	4	yelkenci	yelkenci	PROPN
admet-2874	565	5	,	,	PUNCT
admet-2874	565	6	o.	o.	PROPN
admet-2874	565	7	tavukcuoglu	tavukcuoglu	PROPN
admet-2874	565	8	,	,	PUNCT
admet-2874	565	9	m.	m.	NOUN
admet-2874	565	10	ghorbanpour	ghorbanpour	NOUN
admet-2874	565	11	.	.	PUNCT
admet-2874	566	1	advances	advance	NOUN
admet-2874	566	2	in	in	ADP
admet-2874	566	3	drug	drug	NOUN
admet-2874	566	4	targeting	targeting	NOUN
admet-2874	566	5	,	,	PUNCT
admet-2874	566	6	drug	drug	NOUN
admet-2874	566	7	delivery	delivery	NOUN
admet-2874	566	8	,	,	PUNCT
admet-2874	566	9	and	and	CCONJ
admet-2874	566	10	nanotechnology	nanotechnology	NOUN
admet-2874	566	11	applications	application	NOUN
admet-2874	566	12	:	:	PUNCT
admet-2874	566	13	therapeutic	therapeutic	ADJ
admet-2874	566	14	significance	significance	NOUN
admet-2874	566	15	in	in	ADP
admet-2874	566	16	https://doi.org/10.1056/nejmoa2413258	https://doi.org/10.1056/nejmoa2413258	PROPN
admet-2874	566	17	https://doi.org/10.1016/j.biopha.2025.118249	https://doi.org/10.1016/j.biopha.2025.118249	ADJ
admet-2874	566	18	https://doi.org/10.1016/j.cgh.2022.05.056	https://doi.org/10.1016/j.cgh.2022.05.056	NOUN
admet-2874	566	19	https://doi.org/10.1038/s41598-025-94401-7	https://doi.org/10.1038/s41598-025-94401-7	PRON
admet-2874	566	20	https://doi.org/10.1155/2023/5891532	https://doi.org/10.1155/2023/5891532	NOUN
admet-2874	566	21	https://doi.org/10.1080/13543784.2020.1668374	https://doi.org/10.1080/13543784.2020.1668374	NOUN
admet-2874	567	1	https://doi.org/10.1016/j.cgh.2023.04.011	https://doi.org/10.1016/j.cgh.2023.04.011	PROPN
admet-2874	567	2	https://doi.org/10.1097/hep.0000000000000607	https://doi.org/10.1097/hep.0000000000000607	PROPN
admet-2874	567	3	https://doi.org/10.1097/hep.0000000000000980	https://doi.org/10.1097/hep.0000000000000980	PROPN
admet-2874	567	4	admet	admet	PROPN
admet-2874	567	5	&	&	CCONJ
admet-2874	567	6	dmpk	dmpk	PROPN
admet-2874	567	7	13(4	13(4	NUM
admet-2874	567	8	)	)	PUNCT
admet-2874	567	9	(	(	PUNCT
admet-2874	567	10	2025	2025	NUM
admet-2874	567	11	)	)	PUNCT
admet-2874	567	12	2874	2874	NUM
admet-2874	567	13	hscs	hsc	NOUN
admet-2874	567	14	in	in	ADP
admet-2874	567	15	liver	liver	NOUN
admet-2874	567	16	fibrosis	fibrosis	NOUN
admet-2874	567	17	:	:	PUNCT
admet-2874	567	18	therapeutic	therapeutic	ADJ
admet-2874	567	19	advances	advance	NOUN
admet-2874	567	20	doi	doi	NOUN
admet-2874	567	21	:	:	PUNCT
admet-2874	567	22	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	567	23	21	21	NUM
admet-2874	567	24	cancer	cancer	NOUN
admet-2874	567	25	treatment	treatment	NOUN
admet-2874	567	26	.	.	PUNCT
admet-2874	568	1	pharmaceutics	pharmaceutic	NOUN
admet-2874	568	2	17	17	NUM
admet-2874	568	3	(	(	PUNCT
admet-2874	568	4	2025	2025	NUM
admet-2874	568	5	)	)	PUNCT
admet-2874	568	6	121	121	NUM
admet-2874	568	7	.	.	PUNCT
admet-2874	569	1	https://doi.org/10.3390/pharmaceutics17010121	https://doi.org/10.3390/pharmaceutics17010121	PROPN
admet-2874	569	2	76	76	NUM
admet-2874	569	3	.	.	PUNCT
admet-2874	570	1	x.	x.	PROPN
admet-2874	570	2	han	han	PROPN
admet-2874	570	3	,	,	PUNCT
admet-2874	570	4	z.y	z.y	PROPN
admet-2874	570	5	.	.	PROPN
admet-2874	570	6	cui	cui	PROPN
admet-2874	570	7	,	,	PUNCT
admet-2874	570	8	j.	j.	PROPN
admet-2874	570	9	song	song	PROPN
admet-2874	570	10	,	,	PUNCT
admet-2874	570	11	h.q	h.q	PROPN
admet-2874	570	12	.	.	PROPN
admet-2874	570	13	piao	piao	PROPN
admet-2874	570	14	,	,	PUNCT
admet-2874	570	15	l.h	l.h	PROPN
admet-2874	570	16	.	.	PROPN
admet-2874	570	17	lian	lian	PROPN
admet-2874	570	18	,	,	PUNCT
admet-2874	570	19	l.s	l.s	PROPN
admet-2874	570	20	.	.	PROPN
admet-2874	570	21	hou	hou	PROPN
admet-2874	570	22	,	,	PUNCT
admet-2874	570	23	g.	g.	PROPN
admet-2874	570	24	wang	wang	PROPN
admet-2874	570	25	,	,	PUNCT
admet-2874	570	26	s.	s.	PROPN
admet-2874	570	27	zheng	zheng	PROPN
admet-2874	570	28	,	,	PUNCT
admet-2874	570	29	x.x	x.x	PROPN
admet-2874	570	30	.	.	PROPN
admet-2874	570	31	dong	dong	PROPN
admet-2874	570	32	,	,	PUNCT
admet-2874	570	33	j.x	j.x	PROPN
admet-2874	570	34	.	.	PROPN
admet-2874	570	35	nan	nan	PROPN
admet-2874	570	36	,	,	PUNCT
admet-2874	570	37	y.l	y.l	PROPN
admet-2874	570	38	.	.	PROPN
admet-2874	570	39	wu	wu	PROPN
admet-2874	570	40	.	.	PUNCT
admet-2874	571	1	acanthoic	acanthoic	ADJ
admet-2874	571	2	acid	acid	ADJ
admet-2874	571	3	modulates	modulate	NOUN
admet-2874	571	4	lipogenesis	lipogenesis	VERB
admet-2874	571	5	in	in	ADP
admet-2874	571	6	nonalcoholic	nonalcoholic	ADJ
admet-2874	571	7	fatty	fatty	NOUN
admet-2874	571	8	liver	liver	NOUN
admet-2874	571	9	disease	disease	NOUN
admet-2874	571	10	via	via	ADP
admet-2874	571	11	fxr	fxr	PROPN
admet-2874	571	12	/	/	SYM
admet-2874	571	13	lxrsdependent	lxrsdependent	PROPN
admet-2874	571	14	manner	manner	NOUN
admet-2874	571	15	.	.	PUNCT
admet-2874	572	1	chemico	chemico	ADJ
admet-2874	572	2	-	-	ADJ
admet-2874	572	3	biological	biological	ADJ
admet-2874	572	4	interactions	interaction	NOUN
admet-2874	572	5	311	311	NUM
admet-2874	572	6	(	(	PUNCT
admet-2874	572	7	2019	2019	NUM
admet-2874	572	8	)	)	PUNCT
admet-2874	572	9	108794	108794	NUM
admet-2874	572	10	.	.	PUNCT
admet-2874	573	1	https://doi.org/10.1016/j.cbi.2019.108794	https://doi.org/10.1016/j.cbi.2019.108794	PROPN
admet-2874	574	1	77	77	NUM
admet-2874	574	2	.	.	PUNCT
admet-2874	574	3	a.	a.	PROPN
admet-2874	574	4	azizsoltani	azizsoltani	PROPN
admet-2874	574	5	,	,	PUNCT
admet-2874	574	6	b.	b.	PROPN
admet-2874	574	7	hatami	hatami	PROPN
admet-2874	574	8	,	,	PUNCT
admet-2874	574	9	m.r	m.r	PROPN
admet-2874	574	10	.	.	PROPN
admet-2874	574	11	zali	zali	PROPN
admet-2874	574	12	,	,	PUNCT
admet-2874	574	13	v.	v.	ADP
admet-2874	574	14	mahdavi	mahdavi	PROPN
admet-2874	574	15	,	,	PUNCT
admet-2874	574	16	k.	k.	PROPN
admet-2874	574	17	baghaei	baghaei	PROPN
admet-2874	574	18	,	,	PUNCT
admet-2874	574	19	e.	e.	PROPN
admet-2874	574	20	alizadeh	alizadeh	PROPN
admet-2874	574	21	.	.	PUNCT
admet-2874	575	1	obeticholic	obeticholic	ADJ
admet-2874	575	2	acid	acid	NOUN
admet-2874	575	3	-	-	PUNCT
admet-2874	575	4	loaded	load	VERB
admet-2874	575	5	exosomes	exosome	NOUN
admet-2874	575	6	attenuate	attenuate	VERB
admet-2874	575	7	liver	liver	NOUN
admet-2874	575	8	fibrosis	fibrosis	NOUN
admet-2874	575	9	through	through	ADP
admet-2874	575	10	dual	dual	ADJ
admet-2874	575	11	targeting	targeting	NOUN
admet-2874	575	12	of	of	ADP
admet-2874	575	13	the	the	DET
admet-2874	575	14	fxr	fxr	NOUN
admet-2874	575	15	signaling	signal	VERB
admet-2874	575	16	pathway	pathway	NOUN
admet-2874	575	17	and	and	CCONJ
admet-2874	575	18	ecm	ecm	NOUN
admet-2874	575	19	remodeling	remodeling	NOUN
admet-2874	575	20	.	.	PUNCT
admet-2874	576	1	biomedicine	biomedicine	NOUN
admet-2874	576	2	pharmacotherapy	pharmacotherapy	NOUN
admet-2874	576	3	168	168	NUM
admet-2874	576	4	(	(	PUNCT
admet-2874	576	5	2023	2023	NUM
admet-2874	576	6	)	)	PUNCT
admet-2874	576	7	115777	115777	NUM
admet-2874	576	8	.	.	PUNCT
admet-2874	577	1	https://doi.org/10.1016/j.biopha.2023.115777	https://doi.org/10.1016/j.biopha.2023.115777	NOUN
admet-2874	577	2	78	78	NUM
admet-2874	577	3	.	.	PUNCT
admet-2874	578	1	s.	s.	PROPN
admet-2874	578	2	girisa	girisa	PROPN
admet-2874	578	3	,	,	PUNCT
admet-2874	578	4	b.s	b.s	PROPN
admet-2874	578	5	.	.	PROPN
admet-2874	578	6	aswani	aswani	PROPN
admet-2874	578	7	,	,	PUNCT
admet-2874	578	8	m.k	m.k	PROPN
admet-2874	578	9	.	.	PROPN
admet-2874	578	10	manickasamy	manickasamy	PROPN
admet-2874	578	11	,	,	PUNCT
admet-2874	578	12	m.	m.	NOUN
admet-2874	578	13	hegde	hegde	PROPN
admet-2874	578	14	,	,	PUNCT
admet-2874	578	15	m.s	m.s	PROPN
admet-2874	578	16	.	.	PROPN
admet-2874	578	17	alqahtani	alqahtani	PROPN
admet-2874	578	18	,	,	PUNCT
admet-2874	578	19	m.	m.	NOUN
admet-2874	578	20	abbas	abbas	PROPN
admet-2874	578	21	,	,	PUNCT
admet-2874	578	22	g.	g.	PROPN
admet-2874	578	23	sethi	sethi	PROPN
admet-2874	578	24	,	,	PUNCT
admet-2874	578	25	a.b	a.b	PROPN
admet-2874	578	26	.	.	PROPN
admet-2874	578	27	kunnumakkara	kunnumakkara	PROPN
admet-2874	578	28	.	.	PUNCT
admet-2874	579	1	restoring	restore	VERB
admet-2874	579	2	fxr	fxr	NOUN
admet-2874	579	3	expression	expression	NOUN
admet-2874	579	4	as	as	ADP
admet-2874	579	5	a	a	DET
admet-2874	579	6	novel	novel	ADJ
admet-2874	579	7	treatment	treatment	NOUN
admet-2874	579	8	strategy	strategy	NOUN
admet-2874	579	9	in	in	ADP
admet-2874	579	10	liver	liver	NOUN
admet-2874	579	11	cancer	cancer	NOUN
admet-2874	579	12	and	and	CCONJ
admet-2874	579	13	other	other	ADJ
admet-2874	579	14	liver	liver	NOUN
admet-2874	579	15	disorders	disorder	NOUN
admet-2874	579	16	.	.	PUNCT
admet-2874	580	1	expert	expert	ADJ
admet-2874	580	2	opinion	opinion	NOUN
admet-2874	580	3	on	on	ADP
admet-2874	580	4	therapeutic	therapeutic	ADJ
admet-2874	580	5	targets	target	NOUN
admet-2874	580	6	29	29	NUM
admet-2874	580	7	(	(	PUNCT
admet-2874	580	8	2025	2025	NUM
admet-2874	580	9	)	)	PUNCT
admet-2874	580	10	193	193	NUM
admet-2874	580	11	-	-	SYM
admet-2874	580	12	221	221	NUM
admet-2874	580	13	.	.	PUNCT
admet-2874	581	1	https://doi.org/10.1080/14728222.2025.2487465	https://doi.org/10.1080/14728222.2025.2487465	ADV
admet-2874	581	2	79	79	NUM
admet-2874	581	3	.	.	PUNCT
admet-2874	582	1	n.s	n.s	PROPN
admet-2874	582	2	.	.	PROPN
admet-2874	582	3	el	el	PROPN
admet-2874	582	4	-	-	PUNCT
admet-2874	582	5	mezayen	mezayen	NOUN
admet-2874	582	6	,	,	PUNCT
admet-2874	582	7	w.f	w.f	PROPN
admet-2874	582	8	.	.	PROPN
admet-2874	582	9	el	el	PROPN
admet-2874	582	10	-	-	PUNCT
admet-2874	582	11	hadidy	hadidy	NOUN
admet-2874	582	12	,	,	PUNCT
admet-2874	582	13	w.m	w.m	PROPN
admet-2874	582	14	.	.	PROPN
admet-2874	583	1	el	el	PROPN
admet-2874	583	2	-	-	PUNCT
admet-2874	583	3	refaie	refaie	NOUN
admet-2874	583	4	,	,	PUNCT
admet-2874	583	5	t.i	t.i	PROPN
admet-2874	583	6	.	.	PROPN
admet-2874	583	7	shalaby	shalaby	PROPN
admet-2874	583	8	,	,	PUNCT
admet-2874	583	9	m.m	m.m	PROPN
admet-2874	583	10	.	.	PROPN
admet-2874	583	11	khattab	khattab	PROPN
admet-2874	583	12	,	,	PUNCT
admet-2874	583	13	a.s	a.s	PROPN
admet-2874	583	14	.	.	PROPN
admet-2874	583	15	el	el	PROPN
admet-2874	583	16	-	-	PUNCT
admet-2874	583	17	khatib	khatib	PROPN
admet-2874	583	18	.	.	PUNCT
admet-2874	584	1	oral	oral	ADJ
admet-2874	584	2	vitamin	vitamin	NOUN
admet-2874	584	3	-	-	PUNCT
admet-2874	584	4	a	a	PRON
admet-2874	584	5	-	-	PUNCT
admet-2874	584	6	coupled	couple	VERB
admet-2874	584	7	valsartan	valsartan	PROPN
admet-2874	584	8	nanomedicine	nanomedicine	PROPN
admet-2874	584	9	:	:	PUNCT
admet-2874	584	10	high	high	ADJ
admet-2874	584	11	hepatic	hepatic	ADJ
admet-2874	584	12	stellate	stellate	ADJ
admet-2874	584	13	cell	cell	NOUN
admet-2874	584	14	receptors	receptor	NOUN
admet-2874	584	15	accessibility	accessibility	NOUN
admet-2874	584	16	and	and	CCONJ
admet-2874	584	17	prolonged	prolonged	ADJ
admet-2874	584	18	enterohepatic	enterohepatic	ADJ
admet-2874	584	19	residence	residence	NOUN
admet-2874	584	20	.	.	PUNCT
admet-2874	585	1	journal	journal	PROPN
admet-2874	585	2	of	of	ADP
admet-2874	585	3	controlled	control	VERB
admet-2874	585	4	release	release	NOUN
admet-2874	585	5	283	283	NUM
admet-2874	585	6	(	(	PUNCT
admet-2874	585	7	2018	2018	NUM
admet-2874	585	8	)	)	PUNCT
admet-2874	585	9	32	32	NUM
admet-2874	585	10	-	-	SYM
admet-2874	585	11	44	44	NUM
admet-2874	585	12	.	.	PUNCT
admet-2874	586	1	https://doi.org/10.1016/j.jconrel.2018.05.021	https://doi.org/10.1016/j.jconrel.2018.05.021	NOUN
admet-2874	586	2	80	80	NUM
admet-2874	586	3	.	.	PUNCT
admet-2874	587	1	y.w	y.w	PROPN
admet-2874	587	2	.	.	PROPN
admet-2874	587	3	zhang	zhang	PROPN
admet-2874	587	4	,	,	PUNCT
admet-2874	587	5	l.s	l.s	PROPN
admet-2874	587	6	.	.	PROPN
admet-2874	587	7	hou	hou	PROPN
admet-2874	587	8	,	,	PUNCT
admet-2874	587	9	j.h	j.h	PROPN
admet-2874	587	10	.	.	PROPN
admet-2874	587	11	xing	xing	PROPN
admet-2874	587	12	,	,	PUNCT
admet-2874	587	13	t.r	t.r	PROPN
admet-2874	587	14	.	.	PROPN
admet-2874	587	15	zhang	zhang	PROPN
admet-2874	587	16	,	,	PUNCT
admet-2874	588	1	s.y	s.y	PROPN
admet-2874	588	2	.	.	PROPN
admet-2874	588	3	zhou	zhou	PROPN
admet-2874	588	4	,	,	PUNCT
admet-2874	588	5	b.l	b.l	PROPN
admet-2874	588	6	.	.	PROPN
admet-2874	588	7	zhang	zhang	PROPN
admet-2874	588	8	.	.	PUNCT
admet-2874	589	1	two	two	NUM
admet-2874	589	2	-	-	PUNCT
admet-2874	589	3	membrane	membrane	NOUN
admet-2874	589	4	hybrid	hybrid	ADJ
admet-2874	589	5	nanobiomimetic	nanobiomimetic	ADJ
admet-2874	589	6	delivery	delivery	NOUN
admet-2874	589	7	system	system	NOUN
admet-2874	589	8	for	for	ADP
admet-2874	589	9	targeted	target	VERB
admet-2874	589	10	autophagy	autophagy	ADJ
admet-2874	589	11	inhibition	inhibition	NOUN
admet-2874	589	12	of	of	ADP
admet-2874	589	13	activated	activate	VERB
admet-2874	589	14	hepatic	hepatic	ADJ
admet-2874	589	15	stellate	stellate	ADJ
admet-2874	589	16	cells	cell	NOUN
admet-2874	589	17	to	to	PART
admet-2874	589	18	synergistically	synergistically	ADV
admet-2874	589	19	treat	treat	VERB
admet-2874	589	20	liver	liver	NOUN
admet-2874	589	21	fibrosis	fibrosis	NOUN
admet-2874	589	22	.	.	PUNCT
admet-2874	590	1	acs	acs	PROPN
admet-2874	590	2	applied	apply	VERB
admet-2874	590	3	materials	material	NOUN
admet-2874	590	4	interfaces	interface	NOUN
admet-2874	590	5	15	15	NUM
admet-2874	590	6	(	(	PUNCT
admet-2874	590	7	2023	2023	NUM
admet-2874	590	8	)	)	PUNCT
admet-2874	590	9	50863	50863	NUM
admet-2874	590	10	-	-	SYM
admet-2874	590	11	50877	50877	NUM
admet-2874	590	12	.	.	PUNCT
admet-2874	591	1	https://doi.org/10.1021/acsami.3c11046	https://doi.org/10.1021/acsami.3c11046	NOUN
admet-2874	591	2	81	81	NUM
admet-2874	591	3	.	.	PUNCT
admet-2874	592	1	s.	s.	PROPN
admet-2874	592	2	tan	tan	PROPN
admet-2874	592	3	,	,	PUNCT
admet-2874	592	4	h.	h.	PROPN
admet-2874	592	5	liu	liu	PROPN
admet-2874	592	6	,	,	PUNCT
admet-2874	592	7	b.	b.	PROPN
admet-2874	592	8	ke	ke	PROPN
admet-2874	592	9	,	,	PUNCT
admet-2874	592	10	j.	j.	PROPN
admet-2874	592	11	jiang	jiang	PROPN
admet-2874	592	12	,	,	PUNCT
admet-2874	592	13	b.	b.	PROPN
admet-2874	592	14	wu	wu	PROPN
admet-2874	592	15	.	.	PUNCT
admet-2874	593	1	the	the	DET
admet-2874	593	2	peripheral	peripheral	ADJ
admet-2874	593	3	cb	cb	PROPN
admet-2874	593	4	receptor	receptor	NOUN
admet-2874	593	5	antagonist	antagonist	NOUN
admet-2874	593	6	jd5037	jd5037	NOUN
admet-2874	593	7	attenuates	attenuate	VERB
admet-2874	593	8	liver	liver	NOUN
admet-2874	593	9	fibrosis	fibrosis	NOUN
admet-2874	593	10	via	via	ADP
admet-2874	593	11	a	a	DET
admet-2874	593	12	cb	cb	NOUN
admet-2874	593	13	receptor	receptor	NOUN
admet-2874	593	14	/	/	SYM
admet-2874	593	15	β	β	NOUN
admet-2874	593	16	-	-	ADJ
admet-2874	593	17	arrestin1	arrestin1	ADJ
admet-2874	593	18	/	/	SYM
admet-2874	593	19	akt	akt	PROPN
admet-2874	593	20	pathway	pathway	NOUN
admet-2874	593	21	.	.	PUNCT
admet-2874	594	1	british	british	ADJ
admet-2874	594	2	journal	journal	PROPN
admet-2874	594	3	of	of	ADP
admet-2874	594	4	pharmacology	pharmacology	NOUN
admet-2874	594	5	177	177	NUM
admet-2874	594	6	(	(	PUNCT
admet-2874	594	7	2020	2020	NUM
admet-2874	594	8	)	)	PUNCT
admet-2874	594	9	2830	2830	NUM
admet-2874	594	10	-	-	SYM
admet-2874	594	11	2847	2847	NUM
admet-2874	594	12	.	.	PUNCT
admet-2874	595	1	https://doi.org/10.1111/bph.15010	https://doi.org/10.1111/bph.15010	PROPN
admet-2874	595	2	82	82	NUM
admet-2874	595	3	.	.	PUNCT
admet-2874	596	1	a.m.	a.m.	PROPN
admet-2874	596	2	ali	ali	PROPN
admet-2874	596	3	,	,	PUNCT
admet-2874	596	4	o.s	o.s	PROPN
admet-2874	596	5	.	.	PROPN
admet-2874	596	6	el	el	PROPN
admet-2874	596	7	-	-	PUNCT
admet-2874	596	8	tawil	tawil	PROPN
admet-2874	596	9	,	,	PUNCT
admet-2874	596	10	a.k	a.k	PROPN
admet-2874	596	11	.	.	PROPN
admet-2874	597	1	al	al	PROPN
admet-2874	597	2	-	-	PUNCT
admet-2874	597	3	mokaddem	mokaddem	PROPN
admet-2874	597	4	,	,	PUNCT
admet-2874	597	5	s.s	s.s	PROPN
admet-2874	597	6	.	.	PROPN
admet-2874	597	7	abd	abd	PROPN
admet-2874	597	8	el	el	PROPN
admet-2874	597	9	-	-	PROPN
admet-2874	597	10	rahman	rahman	PROPN
admet-2874	597	11	.	.	PUNCT
admet-2874	597	12	promoted	promote	VERB
admet-2874	597	13	inhibition	inhibition	NOUN
admet-2874	597	14	of	of	ADP
admet-2874	597	15	tlr4	tlr4	NOUN
admet-2874	597	16	/	/	SYM
admet-2874	597	17	mir-155/	mir-155/	PROPN
admet-2874	597	18	nfkb	nfkb	PROPN
admet-2874	597	19	p65	p65	NOUN
admet-2874	597	20	signaling	signal	VERB
admet-2874	597	21	by	by	ADP
admet-2874	597	22	cannabinoid	cannabinoid	NOUN
admet-2874	597	23	receptor	receptor	NOUN
admet-2874	597	24	2	2	NUM
admet-2874	597	25	agonist	agonist	NOUN
admet-2874	597	26	(	(	PUNCT
admet-2874	597	27	am1241	am1241	PROPN
admet-2874	597	28	)	)	PUNCT
admet-2874	597	29	,	,	PUNCT
admet-2874	597	30	aborts	abort	VERB
admet-2874	597	31	inflammation	inflammation	NOUN
admet-2874	597	32	and	and	CCONJ
admet-2874	597	33	progress	progress	NOUN
admet-2874	597	34	of	of	ADP
admet-2874	597	35	hepatic	hepatic	ADJ
admet-2874	597	36	fibrosis	fibrosis	NOUN
admet-2874	597	37	induced	induce	VERB
admet-2874	597	38	by	by	ADP
admet-2874	597	39	thioacetamide	thioacetamide	NOUN
admet-2874	597	40	.	.	PUNCT
admet-2874	598	1	chemo	chemo	NOUN
admet-2874	598	2	-	-	PUNCT
admet-2874	598	3	biological	biological	ADJ
admet-2874	598	4	interactions	interaction	NOUN
admet-2874	598	5	336	336	NUM
admet-2874	598	6	(	(	PUNCT
admet-2874	598	7	2021	2021	NUM
admet-2874	598	8	)	)	PUNCT
admet-2874	598	9	109398	109398	NUM
admet-2874	598	10	.	.	PUNCT
admet-2874	599	1	https://doi.org/10.1016/j.cbi.2021.109398	https://doi.org/10.1016/j.cbi.2021.109398	PROPN
admet-2874	599	2	83	83	NUM
admet-2874	599	3	.	.	PUNCT
admet-2874	600	1	b.	b.	PROPN
admet-2874	600	2	li	li	PROPN
admet-2874	600	3	,	,	PUNCT
admet-2874	600	4	c.	c.	PROPN
admet-2874	600	5	yan	yan	PROPN
admet-2874	600	6	,	,	PUNCT
admet-2874	600	7	j.	j.	PROPN
admet-2874	600	8	wu	wu	PROPN
admet-2874	600	9	,	,	PUNCT
admet-2874	600	10	k.	k.	PROPN
admet-2874	600	11	stephane	stephane	PROPN
admet-2874	600	12	,	,	PUNCT
admet-2874	600	13	x.	x.	PROPN
admet-2874	600	14	dong	dong	PROPN
admet-2874	600	15	,	,	PUNCT
admet-2874	600	16	y.z	y.z	PROPN
admet-2874	600	17	.	.	PROPN
admet-2874	600	18	zhang	zhang	PROPN
admet-2874	600	19	,	,	PUNCT
admet-2874	600	20	y.	y.	PROPN
admet-2874	600	21	zhang	zhang	PROPN
admet-2874	600	22	,	,	PUNCT
admet-2874	600	23	q.	q.	PROPN
admet-2874	600	24	yu	yu	PROPN
admet-2874	600	25	,	,	PUNCT
admet-2874	600	26	k.y	k.y	PROPN
admet-2874	600	27	.	.	PROPN
admet-2874	600	28	zheng	zheng	PROPN
admet-2874	600	29	.	.	PUNCT
admet-2874	601	1	clonorchis	clonorchis	PROPN
admet-2874	601	2	sinensis	sinensis	NOUN
admet-2874	601	3	esps	esp	VERB
admet-2874	601	4	enhance	enhance	VERB
admet-2874	601	5	the	the	DET
admet-2874	601	6	activation	activation	NOUN
admet-2874	601	7	of	of	ADP
admet-2874	601	8	hepatic	hepatic	ADJ
admet-2874	601	9	stellate	stellate	ADJ
admet-2874	601	10	cells	cell	NOUN
admet-2874	601	11	by	by	ADP
admet-2874	601	12	a	a	DET
admet-2874	601	13	cross	cross	NOUN
admet-2874	601	14	-	-	NOUN
admet-2874	601	15	talk	talk	NOUN
admet-2874	601	16	of	of	ADP
admet-2874	601	17	tlr4	tlr4	NOUN
admet-2874	601	18	and	and	CCONJ
admet-2874	601	19	tgfβ	tgfβ	ADJ
admet-2874	601	20	/	/	SYM
admet-2874	601	21	smads	smad	NOUN
admet-2874	601	22	signaling	signal	VERB
admet-2874	601	23	pathway	pathway	NOUN
admet-2874	601	24	.	.	PUNCT
admet-2874	602	1	acta	acta	PROPN
admet-2874	602	2	tropica	tropica	PROPN
admet-2874	602	3	205	205	NUM
admet-2874	602	4	(	(	PUNCT
admet-2874	602	5	2020	2020	NUM
admet-2874	602	6	)	)	PUNCT
admet-2874	602	7	105307	105307	NUM
admet-2874	602	8	.	.	PUNCT
admet-2874	603	1	https://doi.org/10.1016/j.actatropica.2019.105307	https://doi.org/10.1016/j.actatropica.2019.105307	PROPN
admet-2874	603	2	84	84	NUM
admet-2874	603	3	.	.	PUNCT
admet-2874	604	1	b.l	b.l	PROPN
admet-2874	604	2	.	.	PROPN
admet-2874	604	3	sun	sun	PROPN
admet-2874	604	4	,	,	PUNCT
admet-2874	604	5	x.	x.	PROPN
admet-2874	604	6	sun	sun	PROPN
admet-2874	604	7	,	,	PUNCT
admet-2874	604	8	c.l	c.l	PROPN
admet-2874	604	9	.	.	PROPN
admet-2874	604	10	kempf	kempf	PROPN
admet-2874	604	11	,	,	PUNCT
admet-2874	604	12	j.h	j.h	PROPN
admet-2874	604	13	.	.	PROPN
admet-2874	604	14	song	song	PROPN
admet-2874	604	15	,	,	PUNCT
admet-2874	604	16	n.g	n.g	PROPN
admet-2874	604	17	.	.	PROPN
admet-2874	604	18	casanova	casanova	PROPN
admet-2874	604	19	,	,	PUNCT
admet-2874	604	20	s.m	s.m	PROPN
admet-2874	604	21	.	.	PROPN
admet-2874	604	22	camp	camp	NOUN
admet-2874	604	23	,	,	PUNCT
admet-2874	604	24	v.	v.	PROPN
admet-2874	604	25	reyes	reyes	PROPN
admet-2874	604	26	hernon	hernon	PROPN
admet-2874	604	27	,	,	PUNCT
admet-2874	604	28	m.	m.	PROPN
admet-2874	604	29	fallon	fallon	PROPN
admet-2874	604	30	,	,	PUNCT
admet-2874	604	31	c.	c.	PROPN
admet-2874	604	32	bime	bime	PROPN
admet-2874	604	33	,	,	PUNCT
admet-2874	604	34	d.r	d.r	PROPN
admet-2874	604	35	.	.	PROPN
admet-2874	604	36	martin	martin	PROPN
admet-2874	604	37	,	,	PUNCT
admet-2874	604	38	c.	c.	PROPN
admet-2874	604	39	travelli	travelli	PROPN
admet-2874	604	40	,	,	PUNCT
admet-2874	604	41	d.d	d.d	PROPN
admet-2874	604	42	.	.	PROPN
admet-2874	604	43	zhang	zhang	PROPN
admet-2874	604	44	,	,	PUNCT
admet-2874	604	45	j.g.n	j.g.n	PROPN
admet-2874	604	46	.	.	PUNCT
admet-2874	604	47	garcia	garcia	PROPN
admet-2874	604	48	.	.	PUNCT
admet-2874	605	1	involvement	involvement	NOUN
admet-2874	605	2	of	of	ADP
admet-2874	605	3	enampt	enampt	ADJ
admet-2874	605	4	/	/	SYM
admet-2874	605	5	tlr4	tlr4	NOUN
admet-2874	605	6	inflammatory	inflammatory	NOUN
admet-2874	605	7	signaling	signal	VERB
admet-2874	605	8	in	in	ADP
admet-2874	605	9	progression	progression	NOUN
admet-2874	605	10	of	of	ADP
admet-2874	605	11	non	non	ADJ
admet-2874	605	12	-	-	ADJ
admet-2874	605	13	alcoholic	alcoholic	ADJ
admet-2874	605	14	fatty	fatty	NOUN
admet-2874	605	15	liver	liver	NOUN
admet-2874	605	16	disease	disease	NOUN
admet-2874	605	17	,	,	PUNCT
admet-2874	605	18	steatohepatitis	steatohepatitis	NOUN
admet-2874	605	19	,	,	PUNCT
admet-2874	605	20	and	and	CCONJ
admet-2874	605	21	fibrosis	fibrosis	NOUN
admet-2874	605	22	.	.	PUNCT
admet-2874	606	1	the	the	DET
admet-2874	606	2	faseb	faseb	PROPN
admet-2874	606	3	journal	journal	PROPN
admet-2874	606	4	37	37	NUM
admet-2874	606	5	(	(	PUNCT
admet-2874	606	6	2023	2023	NUM
admet-2874	606	7	)	)	PUNCT
admet-2874	606	8	e22825	e22825	PROPN
admet-2874	606	9	.	.	PUNCT
admet-2874	606	10	https://doi.org/10.1096/fj.202201972rr	https://doi.org/10.1096/fj.202201972rr	PROPN
admet-2874	606	11	85	85	NUM
admet-2874	606	12	.	.	PUNCT
admet-2874	606	13	m.	m.	PROPN
admet-2874	606	14	zhang	zhang	PROPN
admet-2874	606	15	,	,	PUNCT
admet-2874	606	16	e.	e.	PROPN
admet-2874	606	17	barroso	barroso	PROPN
admet-2874	606	18	,	,	PUNCT
admet-2874	606	19	l.	l.	PROPN
admet-2874	606	20	peña	peña	PROPN
admet-2874	606	21	,	,	PUNCT
admet-2874	606	22	p.	p.	NOUN
admet-2874	606	23	rada	rada	PROPN
admet-2874	606	24	,	,	PUNCT
admet-2874	606	25	á.m	á.m	PROPN
admet-2874	606	26	.	.	PROPN
admet-2874	606	27	valverde	valverde	PROPN
admet-2874	606	28	,	,	PUNCT
admet-2874	606	29	w.	w.	PROPN
admet-2874	606	30	wahli	wahli	PROPN
admet-2874	606	31	,	,	PUNCT
admet-2874	606	32	x.	x.	NOUN
admet-2874	606	33	palomer	palomer	NOUN
admet-2874	606	34	,	,	PUNCT
admet-2874	606	35	m.	m.	NOUN
admet-2874	606	36	vázquezcarrera	vázquezcarrera	NOUN
admet-2874	606	37	.	.	PUNCT
admet-2874	607	1	pparβ	pparβ	NOUN
admet-2874	607	2	/	/	SYM
admet-2874	607	3	δ	δ	PROPN
admet-2874	607	4	attenuates	attenuate	VERB
admet-2874	607	5	hepatic	hepatic	ADJ
admet-2874	607	6	fibrosis	fibrosis	NOUN
admet-2874	607	7	by	by	ADP
admet-2874	607	8	reducing	reduce	VERB
admet-2874	607	9	smad3	smad3	NOUN
admet-2874	607	10	phosphorylation	phosphorylation	NOUN
admet-2874	607	11	and	and	CCONJ
admet-2874	607	12	p300	p300	NUM
admet-2874	607	13	levels	level	NOUN
admet-2874	607	14	via	via	ADP
admet-2874	607	15	ampk	ampk	NOUN
admet-2874	607	16	in	in	ADP
admet-2874	607	17	hepatic	hepatic	ADJ
admet-2874	607	18	stellate	stellate	ADJ
admet-2874	607	19	cells	cell	NOUN
admet-2874	607	20	.	.	PUNCT
admet-2874	608	1	biomedicine	biomedicine	NOUN
admet-2874	608	2	and	and	CCONJ
admet-2874	608	3	pharmacotherapy	pharmacotherapy	NOUN
admet-2874	608	4	179	179	NUM
admet-2874	608	5	(	(	PUNCT
admet-2874	608	6	2024	2024	NUM
admet-2874	608	7	)	)	PUNCT
admet-2874	608	8	117303	117303	NUM
admet-2874	608	9	.	.	PUNCT
admet-2874	609	1	https://doi.org/10.1016/j.biopha.2024.117303	https://doi.org/10.1016/j.biopha.2024.117303	ADV
admet-2874	609	2	86	86	NUM
admet-2874	609	3	.	.	PUNCT
admet-2874	610	1	a.n	a.n	PROPN
admet-2874	610	2	.	.	PROPN
admet-2874	610	3	moon	moon	PROPN
admet-2874	610	4	,	,	PUNCT
admet-2874	610	5	f.	f.	PROPN
admet-2874	610	6	briand	briand	PROPN
admet-2874	610	7	,	,	PUNCT
admet-2874	610	8	n.	n.	NOUN
admet-2874	610	9	breyner	breyner	NOUN
admet-2874	610	10	,	,	PUNCT
admet-2874	610	11	d.k	d.k	PROPN
admet-2874	610	12	.	.	PROPN
admet-2874	610	13	song	song	PROPN
admet-2874	610	14	,	,	PUNCT
admet-2874	610	15	m.r	m.r	PROPN
admet-2874	610	16	.	.	PROPN
admet-2874	610	17	madsen	madsen	PROPN
admet-2874	610	18	,	,	PUNCT
admet-2874	610	19	h.	h.	PROPN
admet-2874	610	20	kim	kim	PROPN
admet-2874	610	21	,	,	PUNCT
admet-2874	610	22	k.	k.	PROPN
admet-2874	610	23	choi	choi	PROPN
admet-2874	610	24	,	,	PUNCT
admet-2874	610	25	y.	y.	PROPN
admet-2874	610	26	lee	lee	PROPN
admet-2874	610	27	,	,	PUNCT
admet-2874	610	28	w.	w.	PROPN
admet-2874	610	29	namkung	namkung	PROPN
admet-2874	610	30	.	.	PUNCT
admet-2874	611	1	improvement	improvement	NOUN
admet-2874	611	2	of	of	ADP
admet-2874	611	3	nash	nash	NOUN
admet-2874	611	4	and	and	CCONJ
admet-2874	611	5	liver	liver	NOUN
admet-2874	611	6	fibrosis	fibrosis	NOUN
admet-2874	611	7	through	through	ADP
admet-2874	611	8	modulation	modulation	NOUN
admet-2874	611	9	of	of	ADP
admet-2874	611	10	the	the	DET
admet-2874	611	11	gut	gut	NOUN
admet-2874	611	12	-	-	PUNCT
admet-2874	611	13	liver	liver	NOUN
admet-2874	611	14	axis	axis	NOUN
admet-2874	611	15	by	by	ADP
admet-2874	611	16	a	a	DET
admet-2874	611	17	novel	novel	ADJ
admet-2874	611	18	intestinal	intestinal	ADJ
admet-2874	611	19	fxr	fxr	NOUN
admet-2874	611	20	agonist	agonist	NOUN
admet-2874	611	21	.	.	PUNCT
admet-2874	612	1	biomedicine	biomedicine	NOUN
admet-2874	612	2	pharmacotherapy	pharmacotherapy	NOUN
admet-2874	612	3	173	173	NUM
admet-2874	612	4	(	(	PUNCT
admet-2874	612	5	2024	2024	NUM
admet-2874	612	6	)	)	PUNCT
admet-2874	612	7	116331	116331	NUM
admet-2874	612	8	.	.	PUNCT
admet-2874	613	1	https://doi.org/10.1016/j.biopha.2024.116331	https://doi.org/10.1016/j.biopha.2024.116331	NOUN
admet-2874	613	2	87	87	NUM
admet-2874	613	3	.	.	PUNCT
admet-2874	614	1	h.m	h.m	PROPN
admet-2874	614	2	.	.	PROPN
admet-2874	614	3	liu	liu	PROPN
admet-2874	614	4	,	,	PUNCT
admet-2874	614	5	t.y	t.y	PROPN
admet-2874	614	6	.	.	PROPN
admet-2874	614	7	lee	lee	PROPN
admet-2874	614	8	,	,	PUNCT
admet-2874	614	9	j.f	j.f	PROPN
admet-2874	614	10	.	.	PROPN
admet-2874	614	11	liao	liao	PROPN
admet-2874	614	12	.	.	PUNCT
admet-2874	615	1	gw4064	gw4064	NOUN
admet-2874	615	2	attenuates	attenuate	VERB
admet-2874	615	3	lipopolysaccharide	lipopolysaccharide	ADV
admet-2874	615	4	-	-	PUNCT
admet-2874	615	5	induced	induce	VERB
admet-2874	615	6	hepatic	hepatic	ADJ
admet-2874	615	7	inflammation	inflammation	NOUN
admet-2874	615	8	and	and	CCONJ
admet-2874	615	9	apoptosis	apoptosis	NOUN
admet-2874	615	10	through	through	ADP
admet-2874	615	11	inhibition	inhibition	NOUN
admet-2874	615	12	of	of	ADP
admet-2874	615	13	the	the	DET
admet-2874	615	14	toll	toll	NOUN
admet-2874	615	15	-	-	PUNCT
admet-2874	615	16	like	like	ADJ
admet-2874	615	17	receptor	receptor	NOUN
admet-2874	615	18	4	4	NUM
admet-2874	615	19	-	-	PUNCT
admet-2874	615	20	mediated	mediate	VERB
admet-2874	615	21	p38	p38	NOUN
admet-2874	615	22	mitogen	mitogen	NOUN
admet-2874	615	23	-	-	PUNCT
admet-2874	615	24	activated	activate	VERB
admet-2874	615	25	protein	protein	NOUN
admet-2874	615	26	kinase	kinase	NOUN
admet-2874	615	27	signaling	signal	VERB
admet-2874	615	28	pathway	pathway	NOUN
admet-2874	615	29	in	in	ADP
admet-2874	615	30	mice	mouse	NOUN
admet-2874	615	31	.	.	PUNCT
admet-2874	616	1	international	international	ADJ
admet-2874	616	2	journal	journal	NOUN
admet-2874	616	3	of	of	ADP
admet-2874	616	4	molecular	molecular	ADJ
admet-2874	616	5	medicine	medicine	NOUN
admet-2874	616	6	41	41	NUM
admet-2874	616	7	(	(	PUNCT
admet-2874	616	8	2018	2018	NUM
admet-2874	616	9	)	)	PUNCT
admet-2874	616	10	1455	1455	NUM
admet-2874	616	11	-	-	SYM
admet-2874	616	12	1462	1462	NUM
admet-2874	616	13	.	.	PUNCT
admet-2874	617	1	https://doi.org/10.3892/ijmm.2018.3366	https://doi.org/10.3892/ijmm.2018.3366	PROPN
admet-2874	617	2	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	617	3	https://doi.org/10.3390/pharmaceutics17010121	https://doi.org/10.3390/pharmaceutics17010121	VERB
admet-2874	617	4	https://doi.org/10.1080/14728222.2025.2487465	https://doi.org/10.1080/14728222.2025.2487465	PRON
admet-2874	617	5	https://doi.org/10.1021/acsami.3c11046	https://doi.org/10.1021/acsami.3c11046	NOUN
admet-2874	617	6	https://doi.org/10.1096/fj.202201972rr	https://doi.org/10.1096/fj.202201972rr	X
admet-2874	617	7	https://doi.org/10.1016/j.biopha.2024.117303	https://doi.org/10.1016/j.biopha.2024.117303	PROPN
admet-2874	617	8	https://doi.org/10.3892/ijmm.2018.3366	https://doi.org/10.3892/ijmm.2018.3366	PROPN
admet-2874	617	9	a.	a.	NOUN
admet-2874	617	10	singh	singh	PROPN
admet-2874	617	11	et	et	PROPN
admet-2874	617	12	al	al	PROPN
admet-2874	617	13	.	.	PROPN
admet-2874	617	14	admet	admet	PROPN
admet-2874	617	15	&	&	CCONJ
admet-2874	617	16	dmpk	dmpk	PROPN
admet-2874	617	17	13(4	13(4	NUM
admet-2874	617	18	)	)	PUNCT
admet-2874	617	19	(	(	PUNCT
admet-2874	617	20	2025	2025	NUM
admet-2874	617	21	)	)	PUNCT
admet-2874	617	22	2874	2874	NUM
admet-2874	617	23	22	22	NUM
admet-2874	617	24	88	88	NUM
admet-2874	617	25	.	.	PUNCT
admet-2874	618	1	l.g	l.g	PROPN
admet-2874	618	2	.	.	PROPN
admet-2874	618	3	di	di	PROPN
admet-2874	618	4	pasqua	pasqua	PROPN
admet-2874	618	5	,	,	PUNCT
admet-2874	618	6	m.	m.	NOUN
admet-2874	618	7	cagna	cagna	PROPN
admet-2874	618	8	,	,	PUNCT
admet-2874	618	9	g.	g.	PROPN
admet-2874	618	10	palladini	palladini	PROPN
admet-2874	618	11	,	,	PUNCT
admet-2874	618	12	a.c	a.c	PROPN
admet-2874	618	13	.	.	PROPN
admet-2874	618	14	croce	croce	PROPN
admet-2874	618	15	,	,	PUNCT
admet-2874	618	16	m.	m.	PROPN
admet-2874	618	17	cadamuro	cadamuro	PROPN
admet-2874	618	18	,	,	PUNCT
admet-2874	618	19	l.	l.	PROPN
admet-2874	618	20	fabris	fabris	PROPN
admet-2874	618	21	,	,	PUNCT
admet-2874	618	22	s.	s.	PROPN
admet-2874	618	23	perlini	perlini	PROPN
admet-2874	618	24	,	,	PUNCT
admet-2874	618	25	l.	l.	PROPN
admet-2874	618	26	adorini	adorini	PROPN
admet-2874	618	27	,	,	PUNCT
admet-2874	618	28	a.	a.	NOUN
admet-2874	618	29	ferrigno	ferrigno	PROPN
admet-2874	618	30	,	,	PUNCT
admet-2874	618	31	m.	m.	NOUN
admet-2874	618	32	vairetti	vairetti	PROPN
admet-2874	618	33	.	.	PUNCT
admet-2874	619	1	fxr	fxr	PROPN
admet-2874	619	2	agonists	agonist	NOUN
admet-2874	619	3	int-787	int-787	VERB
admet-2874	619	4	and	and	CCONJ
admet-2874	619	5	oca	oca	NOUN
admet-2874	619	6	increase	increase	NOUN
admet-2874	619	7	reck	reck	NOUN
admet-2874	619	8	and	and	CCONJ
admet-2874	619	9	inhibit	inhibit	VERB
admet-2874	619	10	liver	liver	NOUN
admet-2874	619	11	steatosis	steatosis	NOUN
admet-2874	619	12	and	and	CCONJ
admet-2874	619	13	inflammation	inflammation	NOUN
admet-2874	619	14	in	in	ADP
admet-2874	619	15	diet	diet	NOUN
admet-2874	619	16	-	-	PUNCT
admet-2874	619	17	induced	induce	VERB
admet-2874	619	18	ob	ob	NOUN
admet-2874	619	19	/	/	SYM
admet-2874	619	20	ob	ob	NOUN
admet-2874	619	21	mouse	mouse	NOUN
admet-2874	619	22	model	model	NOUN
admet-2874	619	23	of	of	ADP
admet-2874	619	24	nash	nash	PROPN
admet-2874	619	25	.	.	PUNCT
admet-2874	620	1	liver	liver	PROPN
admet-2874	620	2	international	international	ADJ
admet-2874	620	3	44	44	NUM
admet-2874	620	4	(	(	PUNCT
admet-2874	620	5	2024	2024	NUM
admet-2874	620	6	)	)	PUNCT
admet-2874	620	7	214	214	NUM
admet-2874	620	8	-	-	SYM
admet-2874	620	9	227	227	NUM
admet-2874	620	10	.	.	PUNCT
admet-2874	621	1	https://doi.org/10.1111/liv.15767	https://doi.org/10.1111/liv.15767	NOUN
admet-2874	621	2	89	89	NUM
admet-2874	621	3	.	.	PUNCT
admet-2874	622	1	b.	b.	PROPN
admet-2874	622	2	anfuso	anfuso	PROPN
admet-2874	622	3	,	,	PUNCT
admet-2874	622	4	c.	c.	PROPN
admet-2874	622	5	tiribelli	tiribelli	PROPN
admet-2874	622	6	,	,	PUNCT
admet-2874	622	7	l.	l.	PROPN
admet-2874	622	8	adorini	adorini	PROPN
admet-2874	622	9	,	,	PUNCT
admet-2874	622	10	n.	n.	PROPN
admet-2874	622	11	rosso	rosso	PROPN
admet-2874	622	12	.	.	PROPN
admet-2874	622	13	obeticholic	obeticholic	PROPN
admet-2874	622	14	acid	acid	PROPN
admet-2874	622	15	and	and	CCONJ
admet-2874	622	16	int-767	int-767	AUX
admet-2874	622	17	modulate	modulate	VERB
admet-2874	622	18	collagen	collagen	NOUN
admet-2874	622	19	deposition	deposition	NOUN
admet-2874	622	20	in	in	ADP
admet-2874	622	21	a	a	DET
admet-2874	622	22	nash	nash	NOUN
admet-2874	622	23	in	in	ADP
admet-2874	622	24	vitro	vitro	X
admet-2874	622	25	model	model	NOUN
admet-2874	622	26	.	.	PUNCT
admet-2874	623	1	scientific	scientific	ADJ
admet-2874	623	2	reports	report	NOUN
admet-2874	623	3	10	10	NUM
admet-2874	623	4	(	(	PUNCT
admet-2874	623	5	2020	2020	NUM
admet-2874	623	6	)	)	PUNCT
admet-2874	623	7	1699	1699	NUM
admet-2874	623	8	.	.	PUNCT
admet-2874	624	1	https://doi.org/10.1038/s41598-020-58562-x	https://doi.org/10.1038/s41598-020-58562-x	NOUN
admet-2874	624	2	90	90	NUM
admet-2874	624	3	.	.	PUNCT
admet-2874	625	1	s.	s.	PROPN
admet-2874	625	2	feng	feng	PROPN
admet-2874	625	3	,	,	PUNCT
admet-2874	625	4	x.	x.	PROPN
admet-2874	625	5	xie	xie	PROPN
admet-2874	625	6	,	,	PUNCT
admet-2874	625	7	j.	j.	PROPN
admet-2874	625	8	li	li	PROPN
admet-2874	625	9	,	,	PUNCT
admet-2874	625	10	x.	x.	PROPN
admet-2874	625	11	xu	xu	PROPN
admet-2874	625	12	,	,	PUNCT
admet-2874	625	13	c.	c.	PROPN
admet-2874	625	14	chen	chen	PROPN
admet-2874	625	15	,	,	PUNCT
admet-2874	625	16	g.	g.	PROPN
admet-2874	625	17	zou	zou	PROPN
admet-2874	625	18	,	,	PUNCT
admet-2874	625	19	g.	g.	PROPN
admet-2874	625	20	lin	lin	PROPN
admet-2874	625	21	,	,	PUNCT
admet-2874	625	22	t.	t.	PROPN
admet-2874	625	23	huang	huang	PROPN
admet-2874	625	24	,	,	PUNCT
admet-2874	625	25	r.	r.	PROPN
admet-2874	625	26	hu	hu	PROPN
admet-2874	625	27	,	,	PUNCT
admet-2874	625	28	t.	t.	PROPN
admet-2874	625	29	ran	run	VERB
admet-2874	625	30	,	,	PUNCT
admet-2874	625	31	l.	l.	PROPN
admet-2874	625	32	han	han	PROPN
admet-2874	625	33	,	,	PUNCT
admet-2874	625	34	q.	q.	PROPN
admet-2874	625	35	zhang	zhang	PROPN
admet-2874	625	36	,	,	PUNCT
admet-2874	625	37	y.	y.	PROPN
admet-2874	625	38	li	li	PROPN
admet-2874	625	39	,	,	PUNCT
admet-2874	625	40	x.	x.	PROPN
admet-2874	625	41	zhao	zhao	PROPN
admet-2874	625	42	.	.	PUNCT
admet-2874	626	1	bile	bile	NOUN
admet-2874	626	2	acids	acid	NOUN
admet-2874	626	3	induce	induce	VERB
admet-2874	626	4	liver	liver	NOUN
admet-2874	626	5	fibrosis	fibrosis	NOUN
admet-2874	626	6	through	through	ADP
admet-2874	626	7	the	the	DET
admet-2874	626	8	nlrp3	nlrp3	NOUN
admet-2874	626	9	inflammasome	inflammasome	NOUN
admet-2874	626	10	pathway	pathway	NOUN
admet-2874	626	11	and	and	CCONJ
admet-2874	626	12	the	the	DET
admet-2874	626	13	mechanism	mechanism	NOUN
admet-2874	626	14	of	of	ADP
admet-2874	626	15	fxr	fxr	NOUN
admet-2874	626	16	inhibition	inhibition	NOUN
admet-2874	626	17	of	of	ADP
admet-2874	626	18	nlrp3	nlrp3	ADJ
admet-2874	626	19	activation	activation	NOUN
admet-2874	626	20	.	.	PUNCT
admet-2874	627	1	hepatology	hepatology	PROPN
admet-2874	627	2	international	international	PROPN
admet-2874	627	3	18	18	NUM
admet-2874	627	4	(	(	PUNCT
admet-2874	627	5	2024	2024	NUM
admet-2874	627	6	)	)	PUNCT
admet-2874	627	7	10401052	10401052	NUM
admet-2874	627	8	.	.	PUNCT
admet-2874	628	1	https://doi.org/10.1007/s12072-023-10610-0	https://doi.org/10.1007/s12072-023-10610-0	NOUN
admet-2874	628	2	91	91	NUM
admet-2874	628	3	.	.	PUNCT
admet-2874	629	1	y.	y.	PROPN
admet-2874	629	2	jiang	jiang	PROPN
admet-2874	629	3	,	,	PUNCT
admet-2874	629	4	l.	l.	PROPN
admet-2874	629	5	hou	hou	PROPN
admet-2874	629	6	,	,	PUNCT
admet-2874	629	7	j.	j.	PROPN
admet-2874	629	8	dou	dou	PROPN
admet-2874	629	9	,	,	PUNCT
admet-2874	629	10	m.	m.	PROPN
admet-2874	629	11	xuan	xuan	PROPN
admet-2874	629	12	,	,	PUNCT
admet-2874	629	13	z.	z.	PROPN
admet-2874	629	14	cui	cui	PROPN
admet-2874	629	15	,	,	PUNCT
admet-2874	629	16	l.	l.	PROPN
admet-2874	629	17	lian	lian	PROPN
admet-2874	629	18	,	,	PUNCT
admet-2874	629	19	j.	j.	PROPN
admet-2874	629	20	nan	nan	PROPN
admet-2874	629	21	,	,	PUNCT
admet-2874	629	22	y.	y.	PROPN
admet-2874	629	23	wu	wu	PROPN
admet-2874	629	24	.	.	PROPN
admet-2874	629	25	sesamol	sesamol	PROPN
admet-2874	629	26	as	as	ADP
admet-2874	629	27	a	a	DET
admet-2874	629	28	potential	potential	ADJ
admet-2874	629	29	candidate	candidate	NOUN
admet-2874	629	30	for	for	ADP
admet-2874	629	31	the	the	DET
admet-2874	629	32	treatment	treatment	NOUN
admet-2874	629	33	of	of	ADP
admet-2874	629	34	hepatic	hepatic	ADJ
admet-2874	629	35	fibrosis	fibrosis	NOUN
admet-2874	629	36	,	,	PUNCT
admet-2874	629	37	based	base	VERB
admet-2874	629	38	on	on	ADP
admet-2874	629	39	its	its	PRON
admet-2874	629	40	regulation	regulation	NOUN
admet-2874	629	41	of	of	ADP
admet-2874	629	42	fxr	fxr	NOUN
admet-2874	629	43	/	/	SYM
admet-2874	629	44	lxr	lxr	PROPN
admet-2874	629	45	axis	axis	NOUN
admet-2874	629	46	-	-	PUNCT
admet-2874	629	47	mediated	mediate	VERB
admet-2874	629	48	inhibition	inhibition	NOUN
admet-2874	629	49	of	of	ADP
admet-2874	629	50	autophagy	autophagy	NOUN
admet-2874	629	51	through	through	ADP
admet-2874	629	52	crosstalk	crosstalk	NOUN
admet-2874	629	53	between	between	ADP
admet-2874	629	54	hepatic	hepatic	ADJ
admet-2874	629	55	cells	cell	NOUN
admet-2874	629	56	and	and	CCONJ
admet-2874	629	57	macrophage	macrophage	NOUN
admet-2874	629	58	.	.	PUNCT
admet-2874	630	1	phytomedicine	phytomedicine	NOUN
admet-2874	630	2	123	123	NUM
admet-2874	630	3	(	(	PUNCT
admet-2874	630	4	2024	2024	NUM
admet-2874	630	5	)	)	PUNCT
admet-2874	630	6	155145	155145	NUM
admet-2874	630	7	.	.	PUNCT
admet-2874	631	1	https://doi.org/10.1016/j.phymed.2023.155145	https://doi.org/10.1016/j.phymed.2023.155145	VERB
admet-2874	631	2	92	92	NUM
admet-2874	631	3	.	.	PUNCT
admet-2874	632	1	m.	m.	NOUN
admet-2874	632	2	sengupta	sengupta	PROPN
admet-2874	632	3	,	,	PUNCT
admet-2874	632	4	k.	k.	PROPN
admet-2874	632	5	griffett	griffett	PROPN
admet-2874	632	6	,	,	PUNCT
admet-2874	632	7	c.a	c.a	PROPN
admet-2874	632	8	.	.	PROPN
admet-2874	632	9	flaveny	flaveny	PROPN
admet-2874	632	10	,	,	PUNCT
admet-2874	632	11	t.p	t.p	PROPN
admet-2874	632	12	.	.	PROPN
admet-2874	632	13	burris	burris	PROPN
admet-2874	632	14	.	.	PUNCT
admet-2874	633	1	inhibition	inhibition	NOUN
admet-2874	633	2	of	of	ADP
admet-2874	633	3	hepatotoxicity	hepatotoxicity	NOUN
admet-2874	633	4	by	by	ADP
admet-2874	633	5	a	a	DET
admet-2874	633	6	lxr	lxr	ADJ
admet-2874	633	7	inverse	inverse	NOUN
admet-2874	633	8	agonist	agonist	NOUN
admet-2874	633	9	in	in	ADP
admet-2874	633	10	a	a	DET
admet-2874	633	11	model	model	NOUN
admet-2874	633	12	of	of	ADP
admet-2874	633	13	alcoholic	alcoholic	ADJ
admet-2874	633	14	liver	liver	NOUN
admet-2874	633	15	disease	disease	NOUN
admet-2874	633	16	.	.	PUNCT
admet-2874	634	1	acs	acs	PROPN
admet-2874	634	2	pharmacology	pharmacology	NOUN
admet-2874	634	3	translational	translational	ADJ
admet-2874	634	4	science	science	NOUN
admet-2874	634	5	1	1	NUM
admet-2874	634	6	(	(	PUNCT
admet-2874	634	7	2018	2018	NUM
admet-2874	634	8	)	)	PUNCT
admet-2874	634	9	50	50	NUM
admet-2874	634	10	-	-	SYM
admet-2874	634	11	60	60	NUM
admet-2874	634	12	.	.	PUNCT
admet-2874	635	1	https://doi.org/10.1021/acsptsci.8b00003	https://doi.org/10.1021/acsptsci.8b00003	PROPN
admet-2874	635	2	93	93	NUM
admet-2874	635	3	.	.	PUNCT
admet-2874	636	1	k.	k.	PROPN
admet-2874	636	2	griffett	griffett	PROPN
admet-2874	636	3	,	,	PUNCT
admet-2874	636	4	t.p	t.p	PROPN
admet-2874	636	5	.	.	PROPN
admet-2874	636	6	burris	burris	PROPN
admet-2874	636	7	.	.	PUNCT
admet-2874	637	1	promiscuous	promiscuous	ADJ
admet-2874	637	2	activity	activity	NOUN
admet-2874	637	3	of	of	ADP
admet-2874	637	4	the	the	DET
admet-2874	637	5	lxr	lxr	NOUN
admet-2874	637	6	antagonist	antagonist	NOUN
admet-2874	637	7	gsk2033	gsk2033	NOUN
admet-2874	637	8	in	in	ADP
admet-2874	637	9	a	a	DET
admet-2874	637	10	mouse	mouse	NOUN
admet-2874	637	11	model	model	NOUN
admet-2874	637	12	of	of	ADP
admet-2874	637	13	fatty	fatty	ADJ
admet-2874	637	14	liver	liver	NOUN
admet-2874	637	15	disease	disease	NOUN
admet-2874	637	16	.	.	PUNCT
admet-2874	638	1	biochemical	biochemical	ADJ
admet-2874	638	2	and	and	CCONJ
admet-2874	638	3	biophysical	biophysical	ADJ
admet-2874	638	4	research	research	NOUN
admet-2874	638	5	communications	communication	NOUN
admet-2874	638	6	479	479	NUM
admet-2874	638	7	(	(	PUNCT
admet-2874	638	8	2016	2016	NUM
admet-2874	638	9	)	)	PUNCT
admet-2874	638	10	424428	424428	NUM
admet-2874	638	11	.	.	PUNCT
admet-2874	639	1	https://doi.org/10.1016/j.bbrc.2016.09.036	https://doi.org/10.1016/j.bbrc.2016.09.036	NOUN
admet-2874	639	2	94	94	NUM
admet-2874	639	3	.	.	PUNCT
admet-2874	640	1	f.	f.	PROPN
admet-2874	640	2	zhang	zhang	PROPN
admet-2874	640	3	,	,	PUNCT
admet-2874	640	4	s.	s.	PROPN
admet-2874	640	5	lu	lu	PROPN
admet-2874	640	6	,	,	PUNCT
admet-2874	640	7	j.	j.	PROPN
admet-2874	640	8	he	he	PROPN
admet-2874	640	9	,	,	PUNCT
admet-2874	640	10	h.	h.	PROPN
admet-2874	640	11	jin	jin	PROPN
admet-2874	640	12	,	,	PUNCT
admet-2874	640	13	f.	f.	PROPN
admet-2874	640	14	wang	wang	PROPN
admet-2874	640	15	,	,	PUNCT
admet-2874	640	16	l.	l.	PROPN
admet-2874	640	17	wu	wu	PROPN
admet-2874	640	18	,	,	PUNCT
admet-2874	640	19	j.	j.	PROPN
admet-2874	640	20	shao	shao	PROPN
admet-2874	640	21	,	,	PUNCT
admet-2874	640	22	a.	a.	PROPN
admet-2874	640	23	chen	chen	PROPN
admet-2874	640	24	,	,	PUNCT
admet-2874	640	25	s.	s.	PROPN
admet-2874	640	26	zheng	zheng	PROPN
admet-2874	640	27	.	.	PUNCT
admet-2874	641	1	ligand	ligand	ADJ
admet-2874	641	2	activation	activation	NOUN
admet-2874	641	3	of	of	ADP
admet-2874	641	4	pparγ	pparγ	NOUN
admet-2874	641	5	by	by	ADP
admet-2874	641	6	ligustrazine	ligustrazine	ADJ
admet-2874	641	7	suppresses	suppress	VERB
admet-2874	641	8	pericyte	pericyte	NOUN
admet-2874	641	9	functions	function	NOUN
admet-2874	641	10	of	of	ADP
admet-2874	641	11	hepatic	hepatic	ADJ
admet-2874	641	12	stellate	stellate	ADJ
admet-2874	641	13	cells	cell	NOUN
admet-2874	641	14	via	via	ADP
admet-2874	641	15	smrtmediated	smrtmediate	VERB
admet-2874	641	16	transrepression	transrepression	NOUN
admet-2874	641	17	of	of	ADP
admet-2874	641	18	hif-1α	hif-1α	PROPN
admet-2874	641	19	.	.	PUNCT
admet-2874	642	1	theranostics	theranostic	VERB
admet-2874	642	2	8	8	NUM
admet-2874	642	3	(	(	PUNCT
admet-2874	642	4	2018	2018	NUM
admet-2874	642	5	)	)	PUNCT
admet-2874	642	6	610	610	NUM
admet-2874	642	7	-	-	SYM
admet-2874	642	8	626	626	NUM
admet-2874	642	9	.	.	PUNCT
admet-2874	643	1	https://doi.org/10.7150/thno.22237	https://doi.org/10.7150/thno.22237	PROPN
admet-2874	643	2	95	95	NUM
admet-2874	643	3	.	.	PUNCT
admet-2874	644	1	b.de	b.de	PROPN
admet-2874	644	2	souza	souza	PROPN
admet-2874	644	3	basso	basso	PROPN
admet-2874	644	4	,	,	PUNCT
admet-2874	644	5	g.v	g.v	PROPN
admet-2874	644	6	.	.	PROPN
admet-2874	644	7	haute	haute	PROPN
admet-2874	644	8	,	,	PUNCT
admet-2874	644	9	m.	m.	PROPN
admet-2874	644	10	ortega	ortega	PROPN
admet-2874	644	11	-	-	PUNCT
admet-2874	644	12	ribera	ribera	PROPN
admet-2874	644	13	,	,	PUNCT
admet-2874	644	14	c.	c.	PROPN
admet-2874	644	15	luft	luft	PROPN
admet-2874	644	16	,	,	PUNCT
admet-2874	644	17	g.l	g.l	PROPN
admet-2874	644	18	.	.	PROPN
admet-2874	644	19	antunes	antunes	PROPN
admet-2874	644	20	,	,	PUNCT
admet-2874	644	21	m.s	m.s	PROPN
admet-2874	644	22	.	.	PROPN
admet-2874	644	23	bastos	bastos	PROPN
admet-2874	644	24	,	,	PUNCT
admet-2874	644	25	l.p	l.p	PROPN
admet-2874	644	26	.	.	PROPN
admet-2874	644	27	carlessi	carlessi	PROPN
admet-2874	644	28	,	,	PUNCT
admet-2874	644	29	v.g	v.g	PROPN
admet-2874	644	30	.	.	PROPN
admet-2874	644	31	levorse	levorse	PROPN
admet-2874	644	32	,	,	PUNCT
admet-2874	644	33	e.	e.	PROPN
admet-2874	644	34	cassel	cassel	PROPN
admet-2874	644	35	,	,	PUNCT
admet-2874	644	36	m.v	m.v	PROPN
admet-2874	644	37	.	.	PROPN
admet-2874	644	38	fagundes	fagundes	PROPN
admet-2874	644	39	donadio	donadio	PROPN
admet-2874	644	40	,	,	PUNCT
admet-2874	644	41	e.r	e.r	PROPN
admet-2874	644	42	.	.	PROPN
admet-2874	644	43	santarém	santarém	PROPN
admet-2874	644	44	,	,	PUNCT
admet-2874	644	45	j.	j.	PROPN
admet-2874	644	46	gracia	gracia	PROPN
admet-2874	644	47	-	-	PUNCT
admet-2874	644	48	sancho	sancho	PROPN
admet-2874	644	49	,	,	PUNCT
admet-2874	644	50	j.	j.	PROPN
admet-2874	644	51	rodrigues	rodrigues	PROPN
admet-2874	644	52	de	de	PROPN
admet-2874	644	53	oliveira	oliveira	PROPN
admet-2874	644	54	.	.	PUNCT
admet-2874	645	1	methoxyeugenol	methoxyeugenol	PROPN
admet-2874	645	2	deactivates	deactivate	VERB
admet-2874	645	3	hepatic	hepatic	ADJ
admet-2874	645	4	stellate	stellate	ADJ
admet-2874	645	5	cells	cell	NOUN
admet-2874	645	6	and	and	CCONJ
admet-2874	645	7	attenuates	attenuate	VERB
admet-2874	645	8	liver	liver	NOUN
admet-2874	645	9	fibrosis	fibrosis	NOUN
admet-2874	645	10	and	and	CCONJ
admet-2874	645	11	inflammation	inflammation	NOUN
admet-2874	645	12	through	through	ADP
admet-2874	645	13	a	a	DET
admet-2874	645	14	ppar	ppar	NOUN
admet-2874	645	15	-	-	PUNCT
admet-2874	645	16	ɣ	ɣ	PROPN
admet-2874	645	17	and	and	CCONJ
admet-2874	645	18	nf	nf	NOUN
admet-2874	645	19	-	-	PUNCT
admet-2874	645	20	kb	kb	NOUN
admet-2874	645	21	mechanism	mechanism	NOUN
admet-2874	645	22	.	.	PUNCT
admet-2874	646	1	journal	journal	NOUN
admet-2874	646	2	of	of	ADP
admet-2874	646	3	ethnopharmacology	ethnopharmacology	NOUN
admet-2874	646	4	280	280	NUM
admet-2874	646	5	(	(	PUNCT
admet-2874	646	6	2021	2021	NUM
admet-2874	646	7	)	)	PUNCT
admet-2874	646	8	114433	114433	NUM
admet-2874	646	9	.	.	PUNCT
admet-2874	647	1	https://doi.org/10.1016/j.jep.2021.114433	https://doi.org/10.1016/j.jep.2021.114433	X
admet-2874	648	1	96	96	NUM
admet-2874	648	2	.	.	PUNCT
admet-2874	649	1	l.	l.	PROPN
admet-2874	649	2	chen	chen	PROPN
admet-2874	649	3	,	,	PUNCT
admet-2874	649	4	l.	l.	PROPN
admet-2874	649	5	li	li	PROPN
admet-2874	649	6	,	,	PUNCT
admet-2874	649	7	j.	j.	PROPN
admet-2874	649	8	chen	chen	PROPN
admet-2874	649	9	,	,	PUNCT
admet-2874	649	10	l.	l.	PROPN
admet-2874	649	11	li	li	PROPN
admet-2874	649	12	,	,	PUNCT
admet-2874	649	13	z.	z.	PROPN
admet-2874	649	14	zheng	zheng	PROPN
admet-2874	649	15	,	,	PUNCT
admet-2874	649	16	j.	j.	PROPN
admet-2874	649	17	ren	ren	PROPN
admet-2874	649	18	,	,	PUNCT
admet-2874	649	19	y.	y.	PROPN
admet-2874	649	20	qiu	qiu	PROPN
admet-2874	649	21	.	.	PROPN
admet-2874	649	22	oleoylethanolamide	oleoylethanolamide	PROPN
admet-2874	649	23	,	,	PUNCT
admet-2874	649	24	an	an	DET
admet-2874	649	25	endogenous	endogenous	ADJ
admet-2874	649	26	pparα	pparα	NOUN
admet-2874	649	27	ligand	ligand	NOUN
admet-2874	649	28	,	,	PUNCT
admet-2874	649	29	attenuates	attenuate	VERB
admet-2874	649	30	liver	liver	NOUN
admet-2874	649	31	fibrosis	fibrosis	NOUN
admet-2874	649	32	targeting	target	VERB
admet-2874	649	33	hepatic	hepatic	ADJ
admet-2874	649	34	stellate	stellate	ADJ
admet-2874	649	35	cells	cell	NOUN
admet-2874	649	36	.	.	PUNCT
admet-2874	650	1	oncotarget	oncotarget	NOUN
admet-2874	650	2	6	6	NUM
admet-2874	650	3	(	(	PUNCT
admet-2874	650	4	2015	2015	NUM
admet-2874	650	5	)	)	PUNCT
admet-2874	650	6	4253042540	4253042540	NUM
admet-2874	650	7	.	.	PUNCT
admet-2874	651	1	https://doi.org/10.18632/oncotarget.6466	https://doi.org/10.18632/oncotarget.6466	PROPN
admet-2874	651	2	97	97	NUM
admet-2874	651	3	.	.	PUNCT
admet-2874	651	4	a.	a.	PROPN
admet-2874	651	5	sandoval	sandoval	PROPN
admet-2874	651	6	-	-	PUNCT
admet-2874	651	7	rodriguez	rodriguez	PROPN
admet-2874	651	8	,	,	PUNCT
admet-2874	651	9	h.c	h.c	PROPN
admet-2874	651	10	.	.	PROPN
admet-2874	651	11	monroy	monroy	PROPN
admet-2874	651	12	-	-	PUNCT
admet-2874	651	13	ramirez	ramirez	PROPN
admet-2874	651	14	,	,	PUNCT
admet-2874	651	15	a.	a.	NOUN
admet-2874	651	16	meza	meza	PROPN
admet-2874	651	17	-	-	PUNCT
admet-2874	651	18	rios	rios	PROPN
admet-2874	651	19	,	,	PUNCT
admet-2874	651	20	j.	j.	PROPN
admet-2874	651	21	garcia	garcia	PROPN
admet-2874	651	22	-	-	PUNCT
admet-2874	651	23	bañuelos	bañuelos	PROPN
admet-2874	651	24	,	,	PUNCT
admet-2874	651	25	j.	j.	PROPN
admet-2874	651	26	vera	vera	PROPN
admet-2874	651	27	-	-	PUNCT
admet-2874	651	28	cruz	cruz	PROPN
admet-2874	651	29	,	,	PUNCT
admet-2874	651	30	j.	j.	PROPN
admet-2874	651	31	gutiérrez	gutiérrez	PROPN
admet-2874	651	32	-	-	PUNCT
admet-2874	651	33	cuevas	cuevas	PROPN
admet-2874	651	34	,	,	PUNCT
admet-2874	651	35	j.	j.	PROPN
admet-2874	651	36	silva	silva	PROPN
admet-2874	651	37	-	-	PUNCT
admet-2874	651	38	gomez	gomez	PROPN
admet-2874	651	39	,	,	PUNCT
admet-2874	651	40	b.	b.	PROPN
admet-2874	651	41	staels	staels	PROPN
admet-2874	651	42	,	,	PUNCT
admet-2874	651	43	j.	j.	PROPN
admet-2874	651	44	dominguez	dominguez	PROPN
admet-2874	651	45	-	-	PUNCT
admet-2874	651	46	rosales	rosale	NOUN
admet-2874	651	47	,	,	PUNCT
admet-2874	651	48	m.	m.	NOUN
admet-2874	651	49	galicia	galicia	PROPN
admet-2874	651	50	-	-	PUNCT
admet-2874	651	51	moreno	moreno	PROPN
admet-2874	651	52	,	,	PUNCT
admet-2874	651	53	m.	m.	PROPN
admet-2874	651	54	vazquez	vazquez	PROPN
admet-2874	651	55	-	-	PUNCT
admet-2874	651	56	del	del	PROPN
admet-2874	651	57	mercado	mercado	PROPN
admet-2874	651	58	,	,	PUNCT
admet-2874	651	59	j.	j.	PROPN
admet-2874	651	60	navarro	navarro	PROPN
admet-2874	651	61	-	-	PUNCT
admet-2874	651	62	partida	partida	PROPN
admet-2874	651	63	,	,	PUNCT
admet-2874	651	64	a.	a.	PROPN
admet-2874	651	65	santos	santos	PROPN
admet-2874	651	66	-	-	PUNCT
admet-2874	651	67	garcia	garcia	PROPN
admet-2874	651	68	,	,	PUNCT
admet-2874	651	69	j.	j.	PROPN
admet-2874	651	70	armendariz	armendariz	PROPN
admet-2874	651	71	-	-	PUNCT
admet-2874	651	72	borunda	borunda	NOUN
admet-2874	651	73	.	.	PUNCT
admet-2874	652	1	pirfenidone	pirfenidone	NOUN
admet-2874	652	2	is	be	AUX
admet-2874	652	3	an	an	DET
admet-2874	652	4	agonistic	agonistic	ADJ
admet-2874	652	5	ligand	ligand	NOUN
admet-2874	652	6	for	for	ADP
admet-2874	652	7	pparα	pparα	NOUN
admet-2874	652	8	and	and	CCONJ
admet-2874	652	9	improves	improve	VERB
admet-2874	652	10	nash	nash	NOUN
admet-2874	652	11	by	by	ADP
admet-2874	652	12	activation	activation	NOUN
admet-2874	652	13	of	of	ADP
admet-2874	652	14	sirt1	sirt1	NOUN
admet-2874	652	15	/	/	SYM
admet-2874	652	16	lkb1	lkb1	PROPN
admet-2874	652	17	/	/	SYM
admet-2874	652	18	pampk	pampk	NOUN
admet-2874	652	19	.	.	PUNCT
admet-2874	653	1	hepatology	hepatology	NOUN
admet-2874	653	2	communications	communication	NOUN
admet-2874	653	3	4	4	NUM
admet-2874	653	4	(	(	PUNCT
admet-2874	653	5	2020	2020	NUM
admet-2874	653	6	)	)	PUNCT
admet-2874	653	7	434	434	NUM
admet-2874	653	8	-	-	SYM
admet-2874	653	9	449	449	NUM
admet-2874	653	10	.	.	PUNCT
admet-2874	654	1	https://doi.org/10.1002/hep4.1474	https://doi.org/10.1002/hep4.1474	NOUN
admet-2874	654	2	98	98	NUM
admet-2874	654	3	.	.	PUNCT
admet-2874	655	1	z.	z.	PROPN
admet-2874	655	2	zhou	zhou	PROPN
admet-2874	655	3	,	,	PUNCT
admet-2874	655	4	l.	l.	PROPN
admet-2874	655	5	deng	deng	PROPN
admet-2874	655	6	,	,	PUNCT
admet-2874	655	7	l.	l.	PROPN
admet-2874	655	8	hu	hu	PROPN
admet-2874	655	9	,	,	PUNCT
admet-2874	655	10	q.	q.	PROPN
admet-2874	655	11	ren	ren	PROPN
admet-2874	655	12	,	,	PUNCT
admet-2874	655	13	z.	z.	PROPN
admet-2874	655	14	cai	cai	PROPN
admet-2874	655	15	,	,	PUNCT
admet-2874	655	16	b.	b.	PROPN
admet-2874	655	17	wang	wang	PROPN
admet-2874	655	18	,	,	PUNCT
admet-2874	655	19	z.	z.	PROPN
admet-2874	655	20	li	li	PROPN
admet-2874	655	21	,	,	PUNCT
admet-2874	655	22	l.	l.	PROPN
admet-2874	655	23	zhang	zhang	PROPN
admet-2874	655	24	.	.	PUNCT
admet-2874	656	1	hepatoprotective	hepatoprotective	ADJ
admet-2874	656	2	effects	effect	NOUN
admet-2874	656	3	of	of	ADP
admet-2874	656	4	zly16	zly16	PROPN
admet-2874	656	5	,	,	PUNCT
admet-2874	656	6	a	a	DET
admet-2874	656	7	dual	dual	ADJ
admet-2874	656	8	peroxisome	peroxisome	NOUN
admet-2874	656	9	proliferator	proliferator	NOUN
admet-2874	656	10	-	-	PUNCT
admet-2874	656	11	activated	activate	VERB
admet-2874	656	12	receptor	receptor	NOUN
admet-2874	656	13	α	α	NOUN
admet-2874	656	14	/	/	SYM
admet-2874	656	15	δ	δ	NOUN
admet-2874	656	16	agonist	agonist	NOUN
admet-2874	656	17	,	,	PUNCT
admet-2874	656	18	in	in	ADP
admet-2874	656	19	rodent	rodent	ADJ
admet-2874	656	20	model	model	NOUN
admet-2874	656	21	of	of	ADP
admet-2874	656	22	nonalcoholic	nonalcoholic	PROPN
admet-2874	656	23	steatohepatitis	steatohepatitis	PROPN
admet-2874	656	24	.	.	PUNCT
admet-2874	657	1	european	european	PROPN
admet-2874	657	2	journal	journal	PROPN
admet-2874	657	3	of	of	ADP
admet-2874	657	4	pharmacology	pharmacology	NOUN
admet-2874	657	5	882	882	NUM
admet-2874	657	6	(	(	PUNCT
admet-2874	657	7	2020	2020	NUM
admet-2874	657	8	)	)	PUNCT
admet-2874	657	9	173300	173300	NUM
admet-2874	657	10	.	.	PUNCT
admet-2874	658	1	https://doi.org/10.1016/j.ejphar.2020.173300	https://doi.org/10.1016/j.ejphar.2020.173300	ADJ
admet-2874	658	2	99	99	NUM
admet-2874	658	3	.	.	PUNCT
admet-2874	658	4	a.	a.	PROPN
admet-2874	658	5	honda	honda	PROPN
admet-2874	658	6	,	,	PUNCT
admet-2874	658	7	s.	s.	PROPN
admet-2874	658	8	kamata	kamata	PROPN
admet-2874	658	9	,	,	PUNCT
admet-2874	658	10	c.	c.	PROPN
admet-2874	658	11	satta	satta	PROPN
admet-2874	658	12	,	,	PUNCT
admet-2874	658	13	y.	y.	PROPN
admet-2874	658	14	machida	machida	PROPN
admet-2874	658	15	,	,	PUNCT
admet-2874	658	16	k.	k.	PROPN
admet-2874	658	17	uchii	uchii	PROPN
admet-2874	658	18	,	,	PUNCT
admet-2874	658	19	k.	k.	PROPN
admet-2874	658	20	terasawa	terasawa	PROPN
admet-2874	658	21	,	,	PUNCT
admet-2874	658	22	a.	a.	NOUN
admet-2874	658	23	nemoto	nemoto	NOUN
admet-2874	658	24	,	,	PUNCT
admet-2874	658	25	t.	t.	PROPN
admet-2874	658	26	oyama	oyama	PROPN
admet-2874	658	27	,	,	PUNCT
admet-2874	658	28	i.	i.	PROPN
admet-2874	658	29	ishii	ishii	PROPN
admet-2874	658	30	.	.	PUNCT
admet-2874	659	1	structural	structural	ADJ
admet-2874	659	2	basis	basis	NOUN
admet-2874	659	3	for	for	ADP
admet-2874	659	4	anti	anti	ADJ
admet-2874	659	5	-	-	ADJ
admet-2874	659	6	non	non	ADJ
admet-2874	659	7	-	-	ADJ
admet-2874	659	8	alcoholic	alcoholic	ADJ
admet-2874	659	9	fatty	fatty	NOUN
admet-2874	659	10	liver	liver	NOUN
admet-2874	659	11	disease	disease	NOUN
admet-2874	659	12	and	and	CCONJ
admet-2874	659	13	diabetic	diabetic	ADJ
admet-2874	659	14	dyslipidemia	dyslipidemia	NOUN
admet-2874	659	15	drug	drug	NOUN
admet-2874	659	16	saroglitazar	saroglitazar	NOUN
admet-2874	659	17	as	as	ADP
admet-2874	659	18	a	a	DET
admet-2874	659	19	ppar	ppar	NOUN
admet-2874	659	20	α	α	NOUN
admet-2874	659	21	/	/	SYM
admet-2874	659	22	γ	γ	X
admet-2874	659	23	dual	dual	ADJ
admet-2874	659	24	agonist	agonist	NOUN
admet-2874	659	25	.	.	PUNCT
admet-2874	660	1	biological	biological	ADJ
admet-2874	660	2	and	and	CCONJ
admet-2874	660	3	pharmaceutical	pharmaceutical	ADJ
admet-2874	660	4	bulletin	bulletin	NOUN
admet-2874	660	5	44	44	NUM
admet-2874	660	6	(	(	PUNCT
admet-2874	660	7	2021	2021	NUM
admet-2874	660	8	)	)	PUNCT
admet-2874	660	9	1210	1210	NUM
admet-2874	660	10	.	.	PUNCT
admet-2874	661	1	https://doi.org/10.1248/bpb.b21-00232	https://doi.org/10.1248/bpb.b21-00232	PROPN
admet-2874	661	2	https://doi.org/10.1111/liv.15767	https://doi.org/10.1111/liv.15767	PROPN
admet-2874	661	3	https://doi.org/10.1038/s41598-020-58562-x	https://doi.org/10.1038/s41598-020-58562-x	NOUN
admet-2874	661	4	https://doi.org/10.1007/s12072-023-10610-0	https://doi.org/10.1007/s12072-023-10610-0	PROPN
admet-2874	661	5	https://doi.org/10.1021/acsptsci.8b00003	https://doi.org/10.1021/acsptsci.8b00003	PROPN
admet-2874	661	6	https://doi.org/10.7150/thno.22237	https://doi.org/10.7150/thno.22237	PROPN
admet-2874	661	7	https://doi.org/10.1016/j.jep.2021.114433	https://doi.org/10.1016/j.jep.2021.114433	PROPN
admet-2874	661	8	https://doi.org/10.18632/oncotarget.6466	https://doi.org/10.18632/oncotarget.6466	PROPN
admet-2874	661	9	https://doi.org/10.1002/hep4.1474	https://doi.org/10.1002/hep4.1474	NOUN
admet-2874	661	10	https://doi.org/10.1248/bpb.b21-00232	https://doi.org/10.1248/bpb.b21-00232	PROPN
admet-2874	661	11	admet	admet	PROPN
admet-2874	661	12	&	&	CCONJ
admet-2874	661	13	dmpk	dmpk	PROPN
admet-2874	661	14	13(4	13(4	NUM
admet-2874	661	15	)	)	PUNCT
admet-2874	661	16	(	(	PUNCT
admet-2874	661	17	2025	2025	NUM
admet-2874	661	18	)	)	PUNCT
admet-2874	661	19	2874	2874	NUM
admet-2874	661	20	hscs	hsc	NOUN
admet-2874	661	21	in	in	ADP
admet-2874	661	22	liver	liver	NOUN
admet-2874	661	23	fibrosis	fibrosis	NOUN
admet-2874	661	24	:	:	PUNCT
admet-2874	661	25	therapeutic	therapeutic	ADJ
admet-2874	661	26	advances	advance	NOUN
admet-2874	661	27	doi	doi	NOUN
admet-2874	661	28	:	:	PUNCT
admet-2874	661	29	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	X
admet-2874	661	30	23	23	NUM
admet-2874	661	31	100	100	NUM
admet-2874	661	32	.	.	PUNCT
admet-2874	661	33	m.	m.	NOUN
admet-2874	661	34	kumazoe	kumazoe	PROPN
admet-2874	661	35	,	,	PUNCT
admet-2874	661	36	e.	e.	PROPN
admet-2874	661	37	miyamoto	miyamoto	PROPN
admet-2874	661	38	,	,	PUNCT
admet-2874	661	39	c.	c.	PROPN
admet-2874	661	40	oka	oka	PROPN
admet-2874	661	41	,	,	PUNCT
admet-2874	661	42	m.	m.	NOUN
admet-2874	661	43	kondo	kondo	PROPN
admet-2874	661	44	,	,	PUNCT
admet-2874	661	45	r.	r.	PROPN
admet-2874	661	46	yoshitomi	yoshitomi	PROPN
admet-2874	661	47	,	,	PUNCT
admet-2874	661	48	h.	h.	PROPN
admet-2874	661	49	onda	onda	PROPN
admet-2874	661	50	,	,	PUNCT
admet-2874	661	51	y.	y.	PROPN
admet-2874	661	52	shimada	shimada	PROPN
admet-2874	661	53	,	,	PUNCT
admet-2874	661	54	y.	y.	PROPN
admet-2874	661	55	fujimura	fujimura	PROPN
admet-2874	661	56	,	,	PUNCT
admet-2874	661	57	h.	h.	PROPN
admet-2874	661	58	tachibana	tachibana	PROPN
admet-2874	661	59	.	.	PUNCT
admet-2874	662	1	mir-12135	mir-12135	PROPN
admet-2874	662	2	ameliorates	ameliorate	VERB
admet-2874	662	3	liver	liver	NOUN
admet-2874	662	4	fibrosis	fibrosis	NOUN
admet-2874	662	5	accompanied	accompany	VERB
admet-2874	662	6	with	with	ADP
admet-2874	662	7	the	the	DET
admet-2874	662	8	downregulation	downregulation	NOUN
admet-2874	662	9	of	of	ADP
admet-2874	662	10	integrin	integrin	NOUN
admet-2874	662	11	subunit	subunit	NOUN
admet-2874	662	12	alpha	alpha	PROPN
admet-2874	662	13	11	11	NUM
admet-2874	662	14	.	.	PUNCT
admet-2874	663	1	iscience	iscience	NOUN
admet-2874	663	2	27	27	NUM
admet-2874	663	3	(	(	PUNCT
admet-2874	663	4	2024	2024	NUM
admet-2874	663	5	)	)	PUNCT
admet-2874	663	6	108730	108730	NUM
admet-2874	663	7	.	.	PUNCT
admet-2874	664	1	https://doi.org/10.1016/j.isci.2023.108730	https://doi.org/10.1016/j.isci.2023.108730	PROPN
admet-2874	664	2	101	101	NUM
admet-2874	664	3	.	.	PUNCT
admet-2874	665	1	d.	d.	PROPN
admet-2874	665	2	reichert	reichert	PROPN
admet-2874	665	3	,	,	PUNCT
admet-2874	665	4	l.	l.	PROPN
admet-2874	665	5	adolph	adolph	PROPN
admet-2874	665	6	,	,	PUNCT
admet-2874	665	7	j.p	j.p	PROPN
admet-2874	665	8	.	.	PROPN
admet-2874	665	9	köhler	köhler	PROPN
admet-2874	665	10	,	,	PUNCT
admet-2874	665	11	t.	t.	PROPN
admet-2874	665	12	buschmann	buschmann	PROPN
admet-2874	665	13	,	,	PUNCT
admet-2874	665	14	t.	t.	PROPN
admet-2874	665	15	luedde	luedde	PROPN
admet-2874	665	16	,	,	PUNCT
admet-2874	665	17	d.	d.	PROPN
admet-2874	665	18	häussinger	häussinger	PROPN
admet-2874	665	19	,	,	PUNCT
admet-2874	665	20	c.	c.	PROPN
admet-2874	665	21	kordes	kordes	PROPN
admet-2874	665	22	.	.	PUNCT
admet-2874	666	1	improved	improved	ADJ
admet-2874	666	2	recovery	recovery	NOUN
admet-2874	666	3	from	from	ADP
admet-2874	666	4	liver	liver	NOUN
admet-2874	666	5	fibrosis	fibrosis	NOUN
admet-2874	666	6	by	by	ADP
admet-2874	666	7	crenolanib	crenolanib	NOUN
admet-2874	666	8	.	.	PUNCT
admet-2874	667	1	cells	cell	NOUN
admet-2874	667	2	10	10	NUM
admet-2874	667	3	(	(	PUNCT
admet-2874	667	4	2021	2021	NUM
admet-2874	667	5	)	)	PUNCT
admet-2874	667	6	804	804	NUM
admet-2874	667	7	.	.	PUNCT
admet-2874	668	1	https://doi.org/10.3390/cells10040804	https://doi.org/10.3390/cells10040804	NOUN
admet-2874	668	2	102	102	NUM
admet-2874	668	3	.	.	PUNCT
admet-2874	669	1	f.	f.	PROPN
admet-2874	669	2	liu	liu	PROPN
admet-2874	669	3	,	,	PUNCT
admet-2874	669	4	s.	s.	PROPN
admet-2874	669	5	li	li	PROPN
admet-2874	669	6	,	,	PUNCT
admet-2874	669	7	p.	p.	PROPN
admet-2874	669	8	chen	chen	PROPN
admet-2874	669	9	,	,	PUNCT
admet-2874	669	10	y.	y.	PROPN
admet-2874	669	11	gu	gu	PROPN
admet-2874	669	12	,	,	PUNCT
admet-2874	669	13	s.	s.	PROPN
admet-2874	669	14	wang	wang	PROPN
admet-2874	669	15	,	,	PUNCT
admet-2874	669	16	l.	l.	PROPN
admet-2874	669	17	wang	wang	PROPN
admet-2874	669	18	,	,	PUNCT
admet-2874	669	19	c.	c.	PROPN
admet-2874	669	20	chen	chen	PROPN
admet-2874	669	21	,	,	PUNCT
admet-2874	669	22	r.	r.	PROPN
admet-2874	669	23	wang	wang	PROPN
admet-2874	669	24	,	,	PUNCT
admet-2874	669	25	y.	y.	PROPN
admet-2874	669	26	yuan	yuan	PROPN
admet-2874	669	27	.	.	PUNCT
admet-2874	670	1	salvianolic	salvianolic	ADJ
admet-2874	670	2	acid	acid	PROPN
admet-2874	670	3	b	b	PROPN
admet-2874	670	4	inhibits	inhibit	VERB
admet-2874	670	5	hepatic	hepatic	ADJ
admet-2874	670	6	stellate	stellate	ADJ
admet-2874	670	7	cell	cell	NOUN
admet-2874	670	8	activation	activation	NOUN
admet-2874	670	9	and	and	CCONJ
admet-2874	670	10	liver	liver	NOUN
admet-2874	670	11	fibrosis	fibrosis	NOUN
admet-2874	670	12	by	by	ADP
admet-2874	670	13	targeting	target	VERB
admet-2874	670	14	pdgfrβ	pdgfrβ	NOUN
admet-2874	670	15	.	.	PUNCT
admet-2874	671	1	international	international	ADJ
admet-2874	671	2	immunopharmacology	immunopharmacology	NOUN
admet-2874	671	3	122	122	NUM
admet-2874	671	4	(	(	PUNCT
admet-2874	671	5	2023	2023	NUM
admet-2874	671	6	)	)	PUNCT
admet-2874	671	7	110550	110550	NUM
admet-2874	671	8	.	.	PUNCT
admet-2874	672	1	https://doi.org/10.1016/j.intimp.2023.110550	https://doi.org/10.1016/j.intimp.2023.110550	PROPN
admet-2874	672	2	103	103	NUM
admet-2874	672	3	.	.	PUNCT
admet-2874	673	1	s.	s.	PROPN
admet-2874	673	2	mekala	mekala	PROPN
admet-2874	673	3	,	,	PUNCT
admet-2874	673	4	g.	g.	PROPN
admet-2874	673	5	sukumar	sukumar	PROPN
admet-2874	673	6	,	,	PUNCT
admet-2874	673	7	s.	s.	PROPN
admet-2874	673	8	chawla	chawla	PROPN
admet-2874	673	9	,	,	PUNCT
admet-2874	673	10	r.	r.	PROPN
admet-2874	673	11	geesala	geesala	PROPN
admet-2874	673	12	,	,	PUNCT
admet-2874	673	13	j.	j.	PROPN
admet-2874	673	14	prashanth	prashanth	PROPN
admet-2874	673	15	,	,	PUNCT
admet-2874	673	16	b.j.m	b.j.m	NOUN
admet-2874	673	17	.	.	PUNCT
admet-2874	673	18	reddy	reddy	PROPN
admet-2874	673	19	,	,	PUNCT
admet-2874	673	20	p.	p.	NOUN
admet-2874	673	21	mainkar	mainkar	NOUN
admet-2874	673	22	,	,	PUNCT
admet-2874	673	23	a.	a.	NOUN
admet-2874	673	24	das	das	PROPN
admet-2874	673	25	.	.	PUNCT
admet-2874	674	1	therapeutic	therapeutic	ADJ
admet-2874	674	2	potential	potential	NOUN
admet-2874	674	3	of	of	ADP
admet-2874	674	4	benzimidazoisoquinoline	benzimidazoisoquinoline	NOUN
admet-2874	674	5	derivatives	derivative	NOUN
admet-2874	674	6	in	in	ADP
admet-2874	674	7	alleviating	alleviate	VERB
admet-2874	674	8	murine	murine	ADJ
admet-2874	674	9	hepatic	hepatic	ADJ
admet-2874	674	10	fibrosis	fibrosis	NOUN
admet-2874	674	11	.	.	PUNCT
admet-2874	675	1	chemistry	chemistry	NOUN
admet-2874	675	2	biodiversity	biodiversity	NOUN
admet-2874	675	3	21	21	NUM
admet-2874	675	4	(	(	PUNCT
admet-2874	675	5	2024	2024	NUM
admet-2874	675	6	)	)	PUNCT
admet-2874	675	7	e202301429	e202301429	PROPN
admet-2874	675	8	.	.	NOUN
admet-2874	675	9	https://doi.org/10.1002/cbdv.202301429	https://doi.org/10.1002/cbdv.202301429	ADJ
admet-2874	675	10	104	104	NUM
admet-2874	675	11	.	.	PUNCT
admet-2874	676	1	r.	r.	PROPN
admet-2874	676	2	wang	wang	PROPN
admet-2874	676	3	,	,	PUNCT
admet-2874	676	4	f.	f.	PROPN
admet-2874	676	5	liu	liu	PROPN
admet-2874	676	6	,	,	PUNCT
admet-2874	676	7	p.	p.	PROPN
admet-2874	676	8	chen	chen	PROPN
admet-2874	676	9	,	,	PUNCT
admet-2874	676	10	s.	s.	PROPN
admet-2874	676	11	li	li	PROPN
admet-2874	676	12	,	,	PUNCT
admet-2874	676	13	y.	y.	PROPN
admet-2874	676	14	gu	gu	PROPN
admet-2874	676	15	,	,	PUNCT
admet-2874	676	16	l.	l.	PROPN
admet-2874	676	17	wang	wang	PROPN
admet-2874	676	18	,	,	PUNCT
admet-2874	676	19	c.	c.	PROPN
admet-2874	676	20	chen	chen	PROPN
admet-2874	676	21	,	,	PUNCT
admet-2874	676	22	y.	y.	PROPN
admet-2874	676	23	yuan	yuan	PROPN
admet-2874	676	24	.	.	PUNCT
admet-2874	677	1	gomisin	gomisin	PROPN
admet-2874	677	2	d	d	PROPN
admet-2874	677	3	alleviates	alleviate	VERB
admet-2874	677	4	liver	liver	NOUN
admet-2874	677	5	fibrosis	fibrosis	NOUN
admet-2874	677	6	through	through	ADP
admet-2874	677	7	targeting	target	VERB
admet-2874	677	8	pdgfrβ	pdgfrβ	NOUN
admet-2874	677	9	in	in	ADP
admet-2874	677	10	hepatic	hepatic	ADJ
admet-2874	677	11	stellate	stellate	ADJ
admet-2874	677	12	cells	cell	NOUN
admet-2874	677	13	.	.	PUNCT
admet-2874	678	1	international	international	ADJ
admet-2874	678	2	journal	journal	NOUN
admet-2874	678	3	of	of	ADP
admet-2874	678	4	biological	biological	ADJ
admet-2874	678	5	macromolecules	macromolecule	NOUN
admet-2874	678	6	235	235	NUM
admet-2874	678	7	(	(	PUNCT
admet-2874	678	8	2023	2023	NUM
admet-2874	678	9	)	)	PUNCT
admet-2874	678	10	123639	123639	NUM
admet-2874	678	11	.	.	PUNCT
admet-2874	679	1	https://doi.org/10.1016/j.ijbiomac.2023.123639	https://doi.org/10.1016/j.ijbiomac.2023.123639	PROPN
admet-2874	679	2	105	105	NUM
admet-2874	679	3	.	.	PUNCT
admet-2874	680	1	z.	z.	PROPN
admet-2874	680	2	chen	chen	PROPN
admet-2874	680	3	,	,	PUNCT
admet-2874	680	4	h.	h.	PROPN
admet-2874	680	5	liu	liu	PROPN
admet-2874	680	6	,	,	PUNCT
admet-2874	680	7	a.	a.	PROPN
admet-2874	680	8	jain	jain	PROPN
admet-2874	680	9	,	,	PUNCT
admet-2874	680	10	l.	l.	PROPN
admet-2874	680	11	zhang	zhang	PROPN
admet-2874	680	12	,	,	PUNCT
admet-2874	680	13	c.	c.	PROPN
admet-2874	680	14	liu	liu	PROPN
admet-2874	680	15	,	,	PUNCT
admet-2874	680	16	k.	k.	PROPN
admet-2874	680	17	cheng	cheng	PROPN
admet-2874	680	18	.	.	PUNCT
admet-2874	681	1	discovery	discovery	PROPN
admet-2874	681	2	of	of	ADP
admet-2874	681	3	aptamer	aptamer	NOUN
admet-2874	681	4	ligands	ligand	NOUN
admet-2874	681	5	for	for	ADP
admet-2874	681	6	hepatic	hepatic	ADJ
admet-2874	681	7	stellate	stellate	ADJ
admet-2874	681	8	cells	cell	NOUN
admet-2874	681	9	using	use	VERB
admet-2874	681	10	selex	selex	NOUN
admet-2874	681	11	.	.	PUNCT
admet-2874	682	1	theranostics	theranostic	VERB
admet-2874	682	2	7	7	NUM
admet-2874	682	3	(	(	PUNCT
admet-2874	682	4	2017	2017	NUM
admet-2874	682	5	)	)	PUNCT
admet-2874	682	6	2982	2982	NUM
admet-2874	682	7	-	-	SYM
admet-2874	682	8	2995	2995	NUM
admet-2874	682	9	.	.	PUNCT
admet-2874	683	1	https://doi.org/10.7150/thno.19374	https://doi.org/10.7150/thno.19374	NOUN
admet-2874	683	2	106	106	NUM
admet-2874	683	3	.	.	PUNCT
admet-2874	684	1	a.	a.	PROPN
admet-2874	684	2	mohamed	mohamed	PROPN
admet-2874	684	3	,	,	PUNCT
admet-2874	684	4	o.	o.	PROPN
admet-2874	684	5	el	el	PROPN
admet-2874	684	6	-	-	PUNCT
admet-2874	684	7	tawil	tawil	PROPN
admet-2874	684	8	,	,	PUNCT
admet-2874	684	9	s.	s.	PROPN
admet-2874	684	10	el	el	PROPN
admet-2874	684	11	-	-	PROPN
admet-2874	684	12	rahman	rahman	PROPN
admet-2874	684	13	.	.	PUNCT
admet-2874	685	1	inhibited	inhibit	VERB
admet-2874	685	2	tlr-4	tlr-4	PRON
admet-2874	685	3	/	/	SYM
admet-2874	685	4	nfκb	nfκb	NOUN
admet-2874	685	5	pathway	pathway	NOUN
admet-2874	685	6	mediated	mediate	VERB
admet-2874	685	7	by	by	ADP
admet-2874	685	8	cannabinoid	cannabinoid	NOUN
admet-2874	685	9	receptor	receptor	NOUN
admet-2874	685	10	2	2	NUM
admet-2874	685	11	activation	activation	NOUN
admet-2874	685	12	curbs	curb	NOUN
admet-2874	685	13	ongoing	ongoing	ADJ
admet-2874	685	14	liver	liver	NOUN
admet-2874	685	15	fibrosis	fibrosis	NOUN
admet-2874	685	16	in	in	ADP
admet-2874	685	17	bile	bile	NOUN
admet-2874	685	18	duct	duct	NOUN
admet-2874	685	19	ligated	ligate	VERB
admet-2874	685	20	rats	rat	NOUN
admet-2874	685	21	.	.	PUNCT
admet-2874	686	1	advances	advance	NOUN
admet-2874	686	2	in	in	ADP
admet-2874	686	3	animal	animal	NOUN
admet-2874	686	4	and	and	CCONJ
admet-2874	686	5	veterinary	veterinary	ADJ
admet-2874	686	6	sciences	science	NOUN
admet-2874	686	7	9	9	NUM
admet-2874	686	8	(	(	PUNCT
admet-2874	686	9	2020	2020	NUM
admet-2874	686	10	)	)	PUNCT
admet-2874	686	11	253	253	NUM
admet-2874	686	12	-	-	SYM
admet-2874	686	13	264	264	NUM
admet-2874	686	14	.	.	PUNCT
admet-2874	687	1	https://doi.org/10.17582/journal.aavs/2021/9.2.253.264	https://doi.org/10.17582/journal.aavs/2021/9.2.253.264	NOUN
admet-2874	687	2	107	107	NUM
admet-2874	687	3	.	.	PUNCT
admet-2874	688	1	n.	n.	PROPN
admet-2874	688	2	aljobaily	aljobaily	ADV
admet-2874	688	3	,	,	PUNCT
admet-2874	688	4	k.	k.	PROPN
admet-2874	688	5	krutsinger	krutsinger	PROPN
admet-2874	688	6	,	,	PUNCT
admet-2874	688	7	m.j	m.j	PROPN
admet-2874	688	8	.	.	PROPN
admet-2874	688	9	viereckl	viereckl	PROPN
admet-2874	688	10	,	,	PUNCT
admet-2874	688	11	r.	r.	PROPN
admet-2874	688	12	joly	joly	PROPN
admet-2874	688	13	,	,	PUNCT
admet-2874	688	14	b.	b.	PROPN
admet-2874	688	15	menlove	menlove	PROPN
admet-2874	688	16	,	,	PUNCT
admet-2874	688	17	b.	b.	PROPN
admet-2874	688	18	cone	cone	PROPN
admet-2874	688	19	,	,	PUNCT
admet-2874	688	20	a.	a.	NOUN
admet-2874	688	21	suppes	suppe	NOUN
admet-2874	688	22	,	,	PUNCT
admet-2874	688	23	y.	y.	PROPN
admet-2874	688	24	han	han	PROPN
admet-2874	688	25	.	.	PROPN
admet-2874	689	1	lowdose	lowdose	PROPN
admet-2874	689	2	administration	administration	PROPN
admet-2874	689	3	of	of	ADP
admet-2874	689	4	cannabigerol	cannabigerol	NOUN
admet-2874	689	5	attenuates	attenuate	VERB
admet-2874	689	6	inflammation	inflammation	NOUN
admet-2874	689	7	and	and	CCONJ
admet-2874	689	8	fibrosis	fibrosis	NOUN
admet-2874	689	9	associated	associate	VERB
admet-2874	689	10	with	with	ADP
admet-2874	689	11	methionine	methionine	NOUN
admet-2874	689	12	/	/	SYM
admet-2874	689	13	choline	choline	NOUN
admet-2874	689	14	deficient	deficient	ADJ
admet-2874	689	15	diet	diet	NOUN
admet-2874	689	16	-	-	PUNCT
admet-2874	689	17	induced	induce	VERB
admet-2874	689	18	nash	nash	NOUN
admet-2874	689	19	model	model	NOUN
admet-2874	689	20	via	via	ADP
admet-2874	689	21	modulation	modulation	NOUN
admet-2874	689	22	of	of	ADP
admet-2874	689	23	cannabinoid	cannabinoid	NOUN
admet-2874	689	24	receptor	receptor	NOUN
admet-2874	689	25	.	.	PUNCT
admet-2874	690	1	nutrients	nutrient	NOUN
admet-2874	690	2	15(1	15(1	NUM
admet-2874	690	3	)	)	PUNCT
admet-2874	690	4	(	(	PUNCT
admet-2874	690	5	2023	2023	NUM
admet-2874	690	6	)	)	PUNCT
admet-2874	690	7	178	178	NUM
admet-2874	690	8	.	.	PUNCT
admet-2874	691	1	https://doi.org/10.3390/nu15010178	https://doi.org/10.3390/nu15010178	ADV
admet-2874	691	2	108	108	NUM
admet-2874	691	3	.	.	PUNCT
admet-2874	692	1	v.de	v.de	ADJ
admet-2874	692	2	nunzio	nunzio	PROPN
admet-2874	692	3	,	,	PUNCT
admet-2874	692	4	l.	l.	PROPN
admet-2874	692	5	carrieri	carrieri	PROPN
admet-2874	692	6	,	,	PUNCT
admet-2874	692	7	m.p	m.p	PROPN
admet-2874	692	8	.	.	PROPN
admet-2874	692	9	scavo	scavo	PROPN
admet-2874	692	10	,	,	PUNCT
admet-2874	692	11	t.	t.	PROPN
admet-2874	692	12	lippolis	lippolis	PROPN
admet-2874	692	13	,	,	PUNCT
admet-2874	692	14	m.	m.	NOUN
admet-2874	692	15	cofano	cofano	NOUN
admet-2874	692	16	,	,	PUNCT
admet-2874	692	17	g.r	g.r	PROPN
admet-2874	692	18	.	.	PROPN
admet-2874	692	19	caponio	caponio	PROPN
admet-2874	692	20	,	,	PUNCT
admet-2874	692	21	v.	v.	PROPN
admet-2874	692	22	tutino	tutino	PROPN
admet-2874	692	23	,	,	PUNCT
admet-2874	692	24	f.	f.	PROPN
admet-2874	692	25	rizzi	rizzi	PROPN
admet-2874	692	26	,	,	PUNCT
admet-2874	692	27	n.	n.	PROPN
admet-2874	692	28	depalo	depalo	PROPN
admet-2874	692	29	,	,	PUNCT
admet-2874	692	30	a.r	a.r	PROPN
admet-2874	692	31	.	.	PROPN
admet-2874	692	32	osella	osella	PROPN
admet-2874	692	33	,	,	PUNCT
admet-2874	692	34	m.	m.	NOUN
admet-2874	692	35	notarnicola	notarnicola	PROPN
admet-2874	692	36	.	.	PUNCT
admet-2874	693	1	plasma	plasma	NOUN
admet-2874	693	2	-	-	PUNCT
admet-2874	693	3	derived	derive	VERB
admet-2874	693	4	exosomes	exosome	NOUN
admet-2874	693	5	from	from	ADP
admet-2874	693	6	nafld	nafld	ADJ
admet-2874	693	7	patients	patient	NOUN
admet-2874	693	8	modulate	modulate	VERB
admet-2874	693	9	the	the	DET
admet-2874	693	10	cannabinoid	cannabinoid	NOUN
admet-2874	693	11	receptors	receptor	NOUN
admet-2874	693	12	’	'	PUNCT
admet-2874	693	13	expression	expression	NOUN
admet-2874	693	14	in	in	ADP
admet-2874	693	15	cultured	cultured	ADJ
admet-2874	693	16	heparg	heparg	NOUN
admet-2874	693	17	cells	cell	NOUN
admet-2874	693	18	.	.	PUNCT
admet-2874	694	1	international	international	ADJ
admet-2874	694	2	journal	journal	NOUN
admet-2874	694	3	of	of	ADP
admet-2874	694	4	molecular	molecular	ADJ
admet-2874	694	5	sciences	science	NOUN
admet-2874	694	6	24(2	24(2	NUM
admet-2874	694	7	)	)	PUNCT
admet-2874	694	8	(	(	PUNCT
admet-2874	694	9	2023	2023	NUM
admet-2874	694	10	)	)	PUNCT
admet-2874	694	11	1739	1739	NUM
admet-2874	694	12	.	.	PUNCT
admet-2874	695	1	https://doi.org/10.3390/ijms24021739	https://doi.org/10.3390/ijms24021739	NOUN
admet-2874	695	2	109	109	NUM
admet-2874	695	3	.	.	PUNCT
admet-2874	696	1	l.s	l.s	NOUN
admet-2874	696	2	.	.	PROPN
admet-2874	696	3	hou	hou	PROPN
admet-2874	696	4	,	,	PUNCT
admet-2874	696	5	z.y	z.y	PROPN
admet-2874	696	6	.	.	PROPN
admet-2874	696	7	cui	cui	PROPN
admet-2874	696	8	,	,	PUNCT
admet-2874	696	9	p.	p.	PROPN
admet-2874	696	10	sun	sun	PROPN
admet-2874	696	11	,	,	PUNCT
admet-2874	696	12	h.q	h.q	PROPN
admet-2874	696	13	.	.	PROPN
admet-2874	696	14	piao	piao	PROPN
admet-2874	696	15	,	,	PUNCT
admet-2874	696	16	x.	x.	PROPN
admet-2874	696	17	han	han	PROPN
admet-2874	696	18	,	,	PUNCT
admet-2874	696	19	j.	j.	PROPN
admet-2874	696	20	song	song	PROPN
admet-2874	696	21	,	,	PUNCT
admet-2874	696	22	g.	g.	PROPN
admet-2874	696	23	wang	wang	PROPN
admet-2874	696	24	,	,	PUNCT
admet-2874	696	25	s.	s.	PROPN
admet-2874	696	26	zheng	zheng	PROPN
admet-2874	696	27	,	,	PUNCT
admet-2874	696	28	x.x	x.x	PROPN
admet-2874	696	29	.	.	PROPN
admet-2874	696	30	dong	dong	PROPN
admet-2874	696	31	,	,	PUNCT
admet-2874	696	32	l.	l.	PROPN
admet-2874	696	33	gao	gao	PROPN
admet-2874	696	34	,	,	PUNCT
admet-2874	696	35	y.	y.	PROPN
admet-2874	696	36	zhu	zhu	PROPN
admet-2874	696	37	,	,	PUNCT
admet-2874	696	38	l.h	l.h	PROPN
admet-2874	696	39	.	.	PROPN
admet-2874	696	40	lian	lian	PROPN
admet-2874	696	41	,	,	PUNCT
admet-2874	696	42	j.x	j.x	PROPN
admet-2874	696	43	.	.	PROPN
admet-2874	696	44	nan	nan	PROPN
admet-2874	696	45	,	,	PUNCT
admet-2874	696	46	y.l	y.l	PROPN
admet-2874	696	47	.	.	PROPN
admet-2874	696	48	wu	wu	PROPN
admet-2874	696	49	.	.	PUNCT
admet-2874	697	1	rutin	rutin	NOUN
admet-2874	697	2	mitigates	mitigate	VERB
admet-2874	697	3	hepatic	hepatic	ADJ
admet-2874	697	4	fibrogenesis	fibrogenesis	NOUN
admet-2874	697	5	and	and	CCONJ
admet-2874	697	6	inflammation	inflammation	NOUN
admet-2874	697	7	through	through	ADP
admet-2874	697	8	targeting	target	VERB
admet-2874	697	9	tlr4	tlr4	NOUN
admet-2874	697	10	and	and	CCONJ
admet-2874	697	11	p2x7	p2x7	PROPN
admet-2874	697	12	receptor	receptor	NOUN
admet-2874	697	13	signaling	signal	VERB
admet-2874	697	14	pathway	pathway	NOUN
admet-2874	697	15	in	in	ADP
admet-2874	697	16	vitro	vitro	X
admet-2874	697	17	and	and	CCONJ
admet-2874	697	18	in	in	ADP
admet-2874	697	19	vivo	vivo	NOUN
admet-2874	697	20	.	.	PUNCT
admet-2874	698	1	journal	journal	NOUN
admet-2874	698	2	of	of	ADP
admet-2874	698	3	functional	functional	ADJ
admet-2874	698	4	foods	food	NOUN
admet-2874	698	5	64	64	NUM
admet-2874	698	6	(	(	PUNCT
admet-2874	698	7	2020	2020	NUM
admet-2874	698	8	)	)	PUNCT
admet-2874	698	9	103700	103700	NUM
admet-2874	698	10	.	.	PUNCT
admet-2874	699	1	https://doi.org/10.1016/j.jff.2019.103700	https://doi.org/10.1016/j.jff.2019.103700	PROPN
admet-2874	699	2	110	110	NUM
admet-2874	699	3	.	.	PUNCT
admet-2874	699	4	b.x	b.x	PROPN
admet-2874	699	5	.	.	PROPN
admet-2874	699	6	tang	tang	PROPN
admet-2874	699	7	,	,	PUNCT
admet-2874	699	8	y.	y.	PROPN
admet-2874	699	9	zhang	zhang	PROPN
admet-2874	699	10	,	,	PUNCT
admet-2874	699	11	d.d	d.d	PROPN
admet-2874	699	12	.	.	PROPN
admet-2874	699	13	sun	sun	PROPN
admet-2874	699	14	,	,	PUNCT
admet-2874	699	15	q.y	q.y	PROPN
admet-2874	699	16	.	.	PROPN
admet-2874	699	17	liu	liu	PROPN
admet-2874	699	18	,	,	PUNCT
admet-2874	699	19	c.	c.	PROPN
admet-2874	699	20	li	li	PROPN
admet-2874	699	21	,	,	PUNCT
admet-2874	699	22	p.p	p.p	PROPN
admet-2874	699	23	.	.	PROPN
admet-2874	699	24	wang	wang	PROPN
admet-2874	699	25	,	,	PUNCT
admet-2874	699	26	l.x	l.x	PROPN
admet-2874	699	27	.	.	PUNCT
admet-2874	700	1	gao	gao	PROPN
admet-2874	700	2	,	,	PUNCT
admet-2874	700	3	x.m	x.m	PROPN
admet-2874	700	4	.	.	PROPN
admet-2874	700	5	zhang	zhang	PROPN
admet-2874	700	6	,	,	PUNCT
admet-2874	700	7	j.	j.	PROPN
admet-2874	700	8	li	li	PROPN
admet-2874	700	9	,	,	PUNCT
admet-2874	700	10	w.l	w.l	PROPN
admet-2874	700	11	.	.	PROPN
admet-2874	700	12	zhu	zhu	PROPN
admet-2874	700	13	,	,	PUNCT
admet-2874	700	14	y.	y.	PROPN
admet-2874	700	15	zang	zang	PROPN
admet-2874	700	16	.	.	PUNCT
admet-2874	701	1	luteolin-7	luteolin-7	PROPN
admet-2874	701	2	-	-	PUNCT
admet-2874	701	3	diglucuronide	diglucuronide	NOUN
admet-2874	701	4	,	,	PUNCT
admet-2874	701	5	a	a	DET
admet-2874	701	6	novel	novel	ADJ
admet-2874	701	7	ptp1b	ptp1b	NOUN
admet-2874	701	8	inhibitor	inhibitor	NOUN
admet-2874	701	9	,	,	PUNCT
admet-2874	701	10	ameliorates	ameliorate	VERB
admet-2874	701	11	hepatic	hepatic	ADJ
admet-2874	701	12	stellate	stellate	ADJ
admet-2874	701	13	cell	cell	NOUN
admet-2874	701	14	activation	activation	NOUN
admet-2874	701	15	and	and	CCONJ
admet-2874	701	16	liver	liver	NOUN
admet-2874	701	17	fibrosis	fibrosis	NOUN
admet-2874	701	18	in	in	ADP
admet-2874	701	19	mice	mouse	NOUN
admet-2874	701	20	.	.	PUNCT
admet-2874	702	1	acta	acta	PROPN
admet-2874	702	2	pharmacologica	pharmacologica	PROPN
admet-2874	702	3	sinica	sinica	PROPN
admet-2874	702	4	46	46	NUM
admet-2874	702	5	(	(	PUNCT
admet-2874	702	6	2024	2024	NUM
admet-2874	702	7	)	)	PUNCT
admet-2874	702	8	122	122	NUM
admet-2874	702	9	-	-	SYM
admet-2874	702	10	133	133	NUM
admet-2874	702	11	.	.	PUNCT
admet-2874	703	1	https://doi.org/10.1038/s41401-024-01351-3	https://doi.org/10.1038/s41401-024-01351-3	PROPN
admet-2874	703	2	111	111	NUM
admet-2874	703	3	.	.	PUNCT
admet-2874	704	1	n.m	n.m	PROPN
admet-2874	704	2	.	.	PROPN
admet-2874	704	3	el	el	PROPN
admet-2874	704	4	-	-	PUNCT
admet-2874	704	5	sayed	say	VERB
admet-2874	704	6	,	,	PUNCT
admet-2874	704	7	e.t	e.t	PROPN
admet-2874	704	8	.	.	PROPN
admet-2874	704	9	menze	menze	PROPN
admet-2874	704	10	,	,	PUNCT
admet-2874	704	11	m.g	m.g	PROPN
admet-2874	704	12	.	.	PROPN
admet-2874	704	13	tadros	tadros	PROPN
admet-2874	704	14	,	,	PUNCT
admet-2874	704	15	d.m.f	d.m.f	ADJ
admet-2874	704	16	.	.	PUNCT
admet-2874	704	17	hanna	hanna	PROPN
admet-2874	704	18	.	.	PUNCT
admet-2874	705	1	mangiferin	mangiferin	PROPN
admet-2874	705	2	mitigates	mitigate	NOUN
admet-2874	705	3	methotrexateinduced	methotrexateinduce	VERB
admet-2874	705	4	liver	liver	NOUN
admet-2874	705	5	injury	injury	NOUN
admet-2874	705	6	and	and	CCONJ
admet-2874	705	7	suppresses	suppress	VERB
admet-2874	705	8	hepatic	hepatic	ADJ
admet-2874	705	9	stellate	stellate	ADJ
admet-2874	705	10	cells	cell	NOUN
admet-2874	705	11	activation	activation	NOUN
admet-2874	705	12	in	in	ADP
admet-2874	705	13	rats	rat	NOUN
admet-2874	705	14	:	:	PUNCT
admet-2874	705	15	imperative	imperative	ADJ
admet-2874	705	16	role	role	NOUN
admet-2874	705	17	of	of	ADP
admet-2874	705	18	nrf2	nrf2	NOUN
admet-2874	705	19	/	/	SYM
admet-2874	705	20	nf	nf	PROPN
admet-2874	705	21	-	-	PUNCT
admet-2874	705	22	κb	κb	NOUN
admet-2874	705	23	/	/	SYM
admet-2874	705	24	nlrp3	nlrp3	NOUN
admet-2874	705	25	signaling	signal	VERB
admet-2874	705	26	axis	axis	NOUN
admet-2874	705	27	.	.	PUNCT
admet-2874	706	1	journal	journal	NOUN
admet-2874	706	2	of	of	ADP
admet-2874	706	3	ethnopharmacology	ethnopharmacology	NOUN
admet-2874	706	4	340	340	NUM
admet-2874	706	5	(	(	PUNCT
admet-2874	706	6	2025	2025	NUM
admet-2874	706	7	)	)	PUNCT
admet-2874	706	8	119296	119296	NUM
admet-2874	706	9	.	.	PUNCT
admet-2874	707	1	https://doi.org/10.1016/j.jep.2024.119296	https://doi.org/10.1016/j.jep.2024.119296	PROPN
admet-2874	707	2	112	112	NUM
admet-2874	707	3	.	.	PUNCT
admet-2874	708	1	l.	l.	PROPN
admet-2874	708	2	gan	gan	PROPN
admet-2874	708	3	,	,	PUNCT
admet-2874	708	4	q.	q.	PROPN
admet-2874	708	5	jiang	jiang	PROPN
admet-2874	708	6	,	,	PUNCT
admet-2874	708	7	d.	d.	PROPN
admet-2874	708	8	huang	huang	PROPN
admet-2874	708	9	,	,	PUNCT
admet-2874	708	10	x.	x.	PROPN
admet-2874	708	11	wu	wu	PROPN
admet-2874	708	12	,	,	PUNCT
admet-2874	708	13	x.	x.	PROPN
admet-2874	708	14	zhu	zhu	PROPN
admet-2874	708	15	,	,	PUNCT
admet-2874	708	16	l.	l.	PROPN
admet-2874	708	17	wang	wang	PROPN
admet-2874	708	18	,	,	PUNCT
admet-2874	708	19	w.	w.	PROPN
admet-2874	708	20	xie	xie	PROPN
admet-2874	708	21	,	,	PUNCT
admet-2874	708	22	j.	j.	PROPN
admet-2874	708	23	huang	huang	PROPN
admet-2874	708	24	,	,	PUNCT
admet-2874	708	25	r.	r.	PROPN
admet-2874	708	26	fan	fan	PROPN
admet-2874	708	27	,	,	PUNCT
admet-2874	708	28	y.	y.	PROPN
admet-2874	708	29	jing	jing	PROPN
admet-2874	708	30	,	,	PUNCT
admet-2874	708	31	g.	g.	PROPN
admet-2874	708	32	tang	tang	PROPN
admet-2874	708	33	,	,	PUNCT
admet-2874	708	34	x.	x.	PROPN
admet-2874	708	35	d.	d.	PROPN
admet-2874	708	36	li	li	PROPN
admet-2874	708	37	,	,	PUNCT
admet-2874	708	38	j.	j.	PROPN
admet-2874	708	39	guo	guo	PROPN
admet-2874	708	40	,	,	PUNCT
admet-2874	708	41	s.	s.	PROPN
admet-2874	708	42	yin	yin	PROPN
admet-2874	708	43	.	.	PUNCT
admet-2874	709	1	a	a	DET
admet-2874	709	2	natural	natural	ADJ
admet-2874	709	3	small	small	ADJ
admet-2874	709	4	molecule	molecule	NOUN
admet-2874	709	5	alleviates	alleviate	VERB
admet-2874	709	6	liver	liver	NOUN
admet-2874	709	7	fibrosis	fibrosis	NOUN
admet-2874	709	8	by	by	ADP
admet-2874	709	9	targeting	target	VERB
admet-2874	709	10	apolipoprotein	apolipoprotein	ADJ
admet-2874	709	11	l2	l2	NOUN
admet-2874	709	12	.	.	PUNCT
admet-2874	710	1	nature	nature	NOUN
admet-2874	710	2	chemical	chemical	NOUN
admet-2874	710	3	biology	biology	NOUN
admet-2874	710	4	21	21	NUM
admet-2874	710	5	(	(	PUNCT
admet-2874	710	6	2024	2024	NUM
admet-2874	710	7	)	)	PUNCT
admet-2874	710	8	80	80	NUM
admet-2874	710	9	-	-	SYM
admet-2874	710	10	90	90	NUM
admet-2874	710	11	.	.	PUNCT
admet-2874	711	1	https://doi.org/10.1038/s41589-024-01704-3	https://doi.org/10.1038/s41589-024-01704-3	NUM
admet-2874	711	2	113	113	NUM
admet-2874	711	3	.	.	PUNCT
admet-2874	712	1	l.	l.	PROPN
admet-2874	712	2	huang	huang	PROPN
admet-2874	712	3	,	,	PUNCT
admet-2874	712	4	y.	y.	PROPN
admet-2874	712	5	chen	chen	PROPN
admet-2874	712	6	,	,	PUNCT
admet-2874	712	7	x.	x.	PROPN
admet-2874	712	8	fan	fan	PROPN
admet-2874	712	9	,	,	PUNCT
admet-2874	712	10	x.	x.	PROPN
admet-2874	712	11	zhang	zhang	PROPN
admet-2874	712	12	,	,	PUNCT
admet-2874	712	13	x.	x.	PROPN
admet-2874	712	14	wang	wang	PROPN
admet-2874	712	15	,	,	PUNCT
admet-2874	712	16	l.	l.	PROPN
admet-2874	712	17	liu	liu	PROPN
admet-2874	712	18	,	,	PUNCT
admet-2874	712	19	t.	t.	PROPN
admet-2874	712	20	liu	liu	PROPN
admet-2874	712	21	,	,	PUNCT
admet-2874	712	22	p.	p.	PROPN
admet-2874	712	23	wang	wang	PROPN
admet-2874	712	24	,	,	PUNCT
admet-2874	712	25	a.	a.	PROPN
admet-2874	712	26	xu	xu	PROPN
admet-2874	712	27	,	,	PUNCT
admet-2874	712	28	x.	x.	PROPN
admet-2874	712	29	zhao	zhao	PROPN
admet-2874	712	30	,	,	PUNCT
admet-2874	712	31	m.	m.	NOUN
admet-2874	712	32	cong	cong	PROPN
admet-2874	712	33	.	.	PUNCT
admet-2874	713	1	fluorofenidone	fluorofenidone	NOUN
admet-2874	713	2	mitigates	mitigate	VERB
admet-2874	713	3	liver	liver	NOUN
admet-2874	713	4	fibrosis	fibrosis	NOUN
admet-2874	713	5	through	through	ADP
admet-2874	713	6	gsk-3β	gsk-3β	ADJ
admet-2874	713	7	modulation	modulation	NOUN
admet-2874	713	8	and	and	CCONJ
admet-2874	713	9	hepatocyte	hepatocyte	NOUN
admet-2874	713	10	protection	protection	NOUN
admet-2874	713	11	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	VERB
admet-2874	714	1	https://doi.org/10.1016/j.isci.2023.108730	https://doi.org/10.1016/j.isci.2023.108730	PROPN
admet-2874	714	2	https://doi.org/10.3390/cells10040804	https://doi.org/10.3390/cells10040804	NOUN
admet-2874	714	3	https://doi.org/10.1002/cbdv.202301429	https://doi.org/10.1002/cbdv.202301429	ADJ
admet-2874	714	4	https://doi.org/10.7150/thno.19374	https://doi.org/10.7150/thno.19374	NOUN
admet-2874	714	5	https://doi.org/10.17582/journal.aavs/2021/9.2.253.264	https://doi.org/10.17582/journal.aavs/2021/9.2.253.264	NOUN
admet-2874	714	6	https://doi.org/10.3390/nu15010178	https://doi.org/10.3390/nu15010178	ADJ
admet-2874	714	7	https://doi.org/10.3390/ijms24021739	https://doi.org/10.3390/ijms24021739	NOUN
admet-2874	714	8	https://doi.org/10.1038/s41401-024-01351-3	https://doi.org/10.1038/s41401-024-01351-3	NUM
admet-2874	714	9	https://doi.org/10.1016/j.jep.2024.119296	https://doi.org/10.1016/j.jep.2024.119296	PROPN
admet-2874	715	1	https://doi.org/10.1038/s41589-024-01704-3	https://doi.org/10.1038/s41589-024-01704-3	NUM
admet-2874	715	2	a.	a.	NOUN
admet-2874	715	3	singh	singh	PROPN
admet-2874	715	4	et	et	PROPN
admet-2874	715	5	al	al	PROPN
admet-2874	715	6	.	.	PROPN
admet-2874	715	7	admet	admet	PROPN
admet-2874	715	8	&	&	CCONJ
admet-2874	715	9	dmpk	dmpk	PROPN
admet-2874	715	10	13(4	13(4	NUM
admet-2874	715	11	)	)	PUNCT
admet-2874	715	12	(	(	PUNCT
admet-2874	715	13	2025	2025	NUM
admet-2874	715	14	)	)	PUNCT
admet-2874	715	15	2874	2874	NUM
admet-2874	715	16	24	24	NUM
admet-2874	715	17	in	in	ADP
admet-2874	715	18	a	a	DET
admet-2874	715	19	3d	3d	NUM
admet-2874	715	20	tissue	tissue	NOUN
admet-2874	715	21	-	-	PUNCT
admet-2874	715	22	engineered	engineer	VERB
admet-2874	715	23	model	model	NOUN
admet-2874	715	24	.	.	PUNCT
admet-2874	716	1	international	international	ADJ
admet-2874	716	2	immunopharmacology	immunopharmacology	NOUN
admet-2874	716	3	149	149	NUM
admet-2874	716	4	(	(	PUNCT
admet-2874	716	5	2025	2025	NUM
admet-2874	716	6	)	)	PUNCT
admet-2874	716	7	114209	114209	NUM
admet-2874	716	8	.	.	PUNCT
admet-2874	717	1	https://doi.org/10.1016/j.intimp.2025.114209	https://doi.org/10.1016/j.intimp.2025.114209	NOUN
admet-2874	717	2	114	114	NUM
admet-2874	717	3	.	.	PUNCT
admet-2874	718	1	m.	m.	PROPN
admet-2874	718	2	lv	lv	PROPN
admet-2874	718	3	,	,	PUNCT
admet-2874	718	4	s.	s.	PROPN
admet-2874	718	5	chen	chen	PROPN
admet-2874	718	6	,	,	PUNCT
admet-2874	718	7	m.	m.	NOUN
admet-2874	718	8	shan	shan	PROPN
admet-2874	718	9	,	,	PUNCT
admet-2874	718	10	y.	y.	PROPN
admet-2874	718	11	si	si	PROPN
admet-2874	718	12	,	,	PUNCT
admet-2874	718	13	c.	c.	PROPN
admet-2874	718	14	huang	huang	PROPN
admet-2874	718	15	,	,	PUNCT
admet-2874	718	16	j.	j.	PROPN
admet-2874	718	17	chen	chen	PROPN
admet-2874	718	18	,	,	PUNCT
admet-2874	718	19	l.	l.	PROPN
admet-2874	718	20	gong	gong	PROPN
admet-2874	718	21	.	.	PUNCT
admet-2874	719	1	arctigenin	arctigenin	PROPN
admet-2874	719	2	induces	induce	VERB
admet-2874	719	3	activated	activate	VERB
admet-2874	719	4	hscs	hsc	NOUN
admet-2874	719	5	quiescence	quiescence	NOUN
admet-2874	719	6	via	via	ADP
admet-2874	719	7	ampk	ampk	NOUN
admet-2874	719	8	-	-	PUNCT
admet-2874	719	9	pparγ	pparγ	NOUN
admet-2874	719	10	pathway	pathway	NOUN
admet-2874	719	11	to	to	PART
admet-2874	719	12	ameliorate	ameliorate	VERB
admet-2874	719	13	liver	liver	NOUN
admet-2874	719	14	fibrosis	fibrosis	NOUN
admet-2874	719	15	in	in	ADP
admet-2874	719	16	mice	mouse	NOUN
admet-2874	719	17	.	.	PUNCT
admet-2874	720	1	european	european	ADJ
admet-2874	720	2	journal	journal	PROPN
admet-2874	720	3	of	of	ADP
admet-2874	720	4	pharmacology	pharmacology	NOUN
admet-2874	720	5	974	974	NUM
admet-2874	720	6	(	(	PUNCT
admet-2874	720	7	2024	2024	NUM
admet-2874	720	8	)	)	PUNCT
admet-2874	720	9	176629	176629	NUM
admet-2874	720	10	.	.	PUNCT
admet-2874	721	1	https://doi.org/10.1016/j.ejphar.2024.176629	https://doi.org/10.1016/j.ejphar.2024.176629	NOUN
admet-2874	721	2	115	115	NUM
admet-2874	721	3	.	.	PUNCT
admet-2874	722	1	m.ten	m.ten	PROPN
admet-2874	722	2	hove	hove	PROPN
admet-2874	722	3	,	,	PUNCT
admet-2874	722	4	a.	a.	NOUN
admet-2874	722	5	smyris	smyris	PROPN
admet-2874	722	6	,	,	PUNCT
admet-2874	722	7	r.	r.	PROPN
admet-2874	722	8	booijink	booijink	PROPN
admet-2874	722	9	,	,	PUNCT
admet-2874	722	10	l.	l.	PROPN
admet-2874	722	11	wachsmuth	wachsmuth	PROPN
admet-2874	722	12	,	,	PUNCT
admet-2874	722	13	u.	u.	PROPN
admet-2874	722	14	hansen	hansen	PROPN
admet-2874	722	15	,	,	PUNCT
admet-2874	722	16	l.	l.	PROPN
admet-2874	722	17	alic	alic	PROPN
admet-2874	722	18	,	,	PUNCT
admet-2874	722	19	c.	c.	PROPN
admet-2874	722	20	faber	faber	PROPN
admet-2874	722	21	,	,	PUNCT
admet-2874	722	22	c.	c.	PROPN
admet-2874	722	23	hӧltke	hӧltke	PROPN
admet-2874	722	24	,	,	PUNCT
admet-2874	722	25	r.	r.	PROPN
admet-2874	722	26	bansal	bansal	PROPN
admet-2874	722	27	.	.	PUNCT
admet-2874	723	1	engineered	engineer	VERB
admet-2874	723	2	spions	spion	NOUN
admet-2874	723	3	functionalized	functionalize	VERB
admet-2874	723	4	with	with	ADP
admet-2874	723	5	endothelin	endothelin	PROPN
admet-2874	723	6	a	a	DET
admet-2874	723	7	receptor	receptor	NOUN
admet-2874	723	8	antagonist	antagonist	NOUN
admet-2874	723	9	ameliorate	ameliorate	VERB
admet-2874	723	10	liver	liver	NOUN
admet-2874	723	11	fibrosis	fibrosis	NOUN
admet-2874	723	12	by	by	ADP
admet-2874	723	13	inhibiting	inhibit	VERB
admet-2874	723	14	hepatic	hepatic	ADJ
admet-2874	723	15	stellate	stellate	ADJ
admet-2874	723	16	cell	cell	NOUN
admet-2874	723	17	activation	activation	NOUN
admet-2874	723	18	.	.	PUNCT
admet-2874	724	1	bioactive	bioactive	ADJ
admet-2874	724	2	materials	material	NOUN
admet-2874	724	3	39	39	NUM
admet-2874	724	4	(	(	PUNCT
admet-2874	724	5	2024	2024	NUM
admet-2874	724	6	)	)	PUNCT
admet-2874	724	7	406426	406426	NUM
admet-2874	724	8	.	.	PUNCT
admet-2874	725	1	https://doi.org/10.1016/j.bioactmat.2024.05.034	https://doi.org/10.1016/j.bioactmat.2024.05.034	VERB
admet-2874	725	2	116	116	NUM
admet-2874	725	3	.	.	PUNCT
admet-2874	725	4	m.	m.	PROPN
admet-2874	725	5	yuan	yuan	PROPN
admet-2874	725	6	,	,	PUNCT
admet-2874	725	7	z.	z.	PROPN
admet-2874	725	8	yin	yin	PROPN
admet-2874	725	9	,	,	PUNCT
admet-2874	725	10	z.	z.	PROPN
admet-2874	725	11	wang	wang	PROPN
admet-2874	725	12	,	,	PUNCT
admet-2874	725	13	z.	z.	PROPN
admet-2874	725	14	xiong	xiong	PROPN
admet-2874	725	15	,	,	PUNCT
admet-2874	725	16	p.	p.	PROPN
admet-2874	725	17	chen	chen	PROPN
admet-2874	725	18	,	,	PUNCT
admet-2874	725	19	l.	l.	PROPN
admet-2874	725	20	yao	yao	PROPN
admet-2874	725	21	,	,	PUNCT
admet-2874	725	22	p.	p.	PROPN
admet-2874	725	23	liu	liu	PROPN
admet-2874	725	24	,	,	PUNCT
admet-2874	725	25	m.	m.	NOUN
admet-2874	725	26	sun	sun	PROPN
admet-2874	725	27	,	,	PUNCT
admet-2874	725	28	k.	k.	PROPN
admet-2874	725	29	shu	shu	PROPN
admet-2874	725	30	,	,	PUNCT
admet-2874	725	31	l.	l.	PROPN
admet-2874	725	32	li	li	PROPN
admet-2874	725	33	,	,	PUNCT
admet-2874	725	34	y.	y.	PROPN
admet-2874	725	35	jiang	jiang	PROPN
admet-2874	725	36	.	.	PUNCT
admet-2874	726	1	modification	modification	NOUN
admet-2874	726	2	of	of	ADP
admet-2874	726	3	mscs	msc	NOUN
admet-2874	726	4	with	with	ADP
admet-2874	726	5	ahscs	ahsc	NOUN
admet-2874	726	6	-	-	PUNCT
admet-2874	726	7	targeting	target	VERB
admet-2874	726	8	peptide	peptide	NOUN
admet-2874	726	9	ppb	ppb	NOUN
admet-2874	726	10	for	for	ADP
admet-2874	726	11	enhanced	enhanced	ADJ
admet-2874	726	12	therapeutic	therapeutic	ADJ
admet-2874	726	13	efficacy	efficacy	NOUN
admet-2874	726	14	in	in	ADP
admet-2874	726	15	liver	liver	NOUN
admet-2874	726	16	fibrosis	fibrosis	NOUN
admet-2874	726	17	.	.	PUNCT
admet-2874	727	1	biomaterials	biomaterial	NOUN
admet-2874	727	2	321	321	NUM
admet-2874	727	3	(	(	PUNCT
admet-2874	727	4	2025	2025	NUM
admet-2874	727	5	)	)	PUNCT
admet-2874	727	6	123295	123295	NUM
admet-2874	727	7	.	.	PUNCT
admet-2874	728	1	https://doi.org/10.1016/j.biomaterials.2025.123295	https://doi.org/10.1016/j.biomaterials.2025.123295	PROPN
admet-2874	728	2	117	117	NUM
admet-2874	728	3	.	.	PUNCT
admet-2874	729	1	p.	p.	PROPN
admet-2874	729	2	yang	yang	PROPN
admet-2874	729	3	,	,	PUNCT
admet-2874	729	4	w.	w.	PROPN
admet-2874	729	5	liu	liu	PROPN
admet-2874	729	6	,	,	PUNCT
admet-2874	729	7	z.	z.	PROPN
admet-2874	729	8	chen	chen	PROPN
admet-2874	729	9	,	,	PUNCT
admet-2874	729	10	d.	d.	PROPN
admet-2874	729	11	duan	duan	PROPN
admet-2874	729	12	,	,	PUNCT
admet-2874	729	13	j.	j.	PROPN
admet-2874	729	14	xu	xu	PROPN
admet-2874	729	15	,	,	PUNCT
admet-2874	729	16	x.	x.	PUNCT
admet-2874	730	1	an	an	X
admet-2874	730	2	,	,	PUNCT
admet-2874	730	3	a.	a.	PROPN
admet-2874	730	4	xie	xie	PROPN
admet-2874	730	5	,	,	PUNCT
admet-2874	730	6	z.	z.	PROPN
admet-2874	730	7	rao	rao	PROPN
admet-2874	730	8	,	,	PUNCT
admet-2874	730	9	y.	y.	PROPN
admet-2874	730	10	xia	xia	PROPN
admet-2874	730	11	,	,	PUNCT
admet-2874	730	12	r.	r.	PROPN
admet-2874	730	13	zhang	zhang	PROPN
admet-2874	730	14	,	,	PUNCT
admet-2874	730	15	p.	p.	PROPN
admet-2874	730	16	ning	ning	PROPN
admet-2874	730	17	,	,	PUNCT
admet-2874	730	18	c.	c.	PROPN
admet-2874	730	19	qiao	qiao	PROPN
admet-2874	730	20	,	,	PUNCT
admet-2874	730	21	x.	x.	PROPN
admet-2874	730	22	zhang	zhang	PROPN
admet-2874	730	23	,	,	PUNCT
admet-2874	730	24	z.	z.	PROPN
admet-2874	730	25	wang	wang	PROPN
admet-2874	730	26	.	.	PUNCT
admet-2874	731	1	sono	sono	PROPN
admet-2874	731	2	-	-	PUNCT
admet-2874	731	3	mediated	mediate	VERB
admet-2874	731	4	glutamine	glutamine	NOUN
admet-2874	731	5	metabolic	metabolic	NOUN
admet-2874	731	6	nanoplatform	nanoplatform	NOUN
admet-2874	731	7	against	against	ADP
admet-2874	731	8	liver	liver	NOUN
admet-2874	731	9	fibrosis	fibrosis	NOUN
admet-2874	731	10	via	via	ADP
admet-2874	731	11	breaking	break	VERB
admet-2874	731	12	the	the	DET
admet-2874	731	13	vicious	vicious	ADJ
admet-2874	731	14	self	self	NOUN
admet-2874	731	15	-	-	PUNCT
admet-2874	731	16	injury	injury	NOUN
admet-2874	731	17	of	of	ADP
admet-2874	731	18	activated	activated	ADJ
admet-2874	731	19	hepatic	hepatic	ADJ
admet-2874	731	20	stellate	stellate	ADJ
admet-2874	731	21	cells	cell	NOUN
admet-2874	731	22	.	.	PUNCT
admet-2874	732	1	nano	nano	NOUN
admet-2874	732	2	today	today	NOUN
admet-2874	732	3	61	61	NUM
admet-2874	732	4	(	(	PUNCT
admet-2874	732	5	2025	2025	NUM
admet-2874	732	6	)	)	PUNCT
admet-2874	732	7	102641	102641	NUM
admet-2874	732	8	.	.	PUNCT
admet-2874	733	1	https://doi.org/10.1016/j.nantod.2025.102641	https://doi.org/10.1016/j.nantod.2025.102641	PROPN
admet-2874	733	2	118	118	NUM
admet-2874	733	3	.	.	PUNCT
admet-2874	734	1	y.	y.	PROPN
admet-2874	734	2	xu	xu	PROPN
admet-2874	734	3	,	,	PUNCT
admet-2874	734	4	y.	y.	PROPN
admet-2874	734	5	fan	fan	PROPN
admet-2874	734	6	,	,	PUNCT
admet-2874	734	7	z.	z.	PROPN
admet-2874	734	8	zhao	zhao	PROPN
admet-2874	734	9	,	,	PUNCT
admet-2874	734	10	w.	w.	PROPN
admet-2874	734	11	hu	hu	PROPN
admet-2874	734	12	,	,	PUNCT
admet-2874	734	13	y.	y.	PROPN
admet-2874	734	14	qian	qian	PROPN
admet-2874	734	15	,	,	PUNCT
admet-2874	734	16	y.	y.	PROPN
admet-2874	734	17	hu	hu	PROPN
admet-2874	734	18	.	.	PROPN
admet-2874	735	1	circularized	circularized	ADJ
admet-2874	735	2	supramolecular	supramolecular	ADJ
admet-2874	735	3	spherical	spherical	ADJ
admet-2874	735	4	nucleic	nucleic	ADJ
admet-2874	735	5	acids	acid	NOUN
admet-2874	735	6	alleviates	alleviate	VERB
admet-2874	735	7	liver	liver	NOUN
admet-2874	735	8	fibrosis	fibrosis	NOUN
admet-2874	735	9	through	through	ADP
admet-2874	735	10	blocking	block	VERB
admet-2874	735	11	upstream	upstream	ADJ
admet-2874	735	12	activation	activation	NOUN
admet-2874	735	13	and	and	CCONJ
admet-2874	735	14	reversing	reverse	VERB
admet-2874	735	15	activation	activation	NOUN
admet-2874	735	16	state	state	NOUN
admet-2874	735	17	of	of	ADP
admet-2874	735	18	hepatic	hepatic	ADJ
admet-2874	735	19	stellate	stellate	ADJ
admet-2874	735	20	cells	cell	NOUN
admet-2874	735	21	.	.	PUNCT
admet-2874	736	1	acs	acs	PROPN
admet-2874	736	2	nano	nano	PROPN
admet-2874	736	3	19(16	19(16	NUM
admet-2874	736	4	)	)	PUNCT
admet-2874	736	5	(	(	PUNCT
admet-2874	736	6	2025	2025	NUM
admet-2874	736	7	)	)	PUNCT
admet-2874	736	8	15444	15444	NUM
admet-2874	736	9	-	-	SYM
admet-2874	736	10	15456	15456	NUM
admet-2874	736	11	.	.	PUNCT
admet-2874	737	1	https://doi.org/10.1021/acsnano.4c15562	https://doi.org/10.1021/acsnano.4c15562	PROPN
admet-2874	737	2	119	119	NUM
admet-2874	737	3	.	.	PUNCT
admet-2874	738	1	j.	j.	PROPN
admet-2874	738	2	huang	huang	PROPN
admet-2874	738	3	,	,	PUNCT
admet-2874	738	4	h.	h.	PROPN
admet-2874	738	5	huang	huang	PROPN
admet-2874	738	6	,	,	PUNCT
admet-2874	738	7	y.	y.	PROPN
admet-2874	738	8	wang	wang	PROPN
admet-2874	738	9	,	,	PUNCT
admet-2874	738	10	b.	b.	PROPN
admet-2874	738	11	xu	xu	PROPN
admet-2874	738	12	,	,	PUNCT
admet-2874	738	13	m.	m.	PROPN
admet-2874	738	14	lin	lin	PROPN
admet-2874	738	15	,	,	PUNCT
admet-2874	738	16	s.	s.	PROPN
admet-2874	738	17	han	han	PROPN
admet-2874	738	18	,	,	PUNCT
admet-2874	738	19	y.	y.	PROPN
admet-2874	738	20	yuan	yuan	PROPN
admet-2874	738	21	,	,	PUNCT
admet-2874	738	22	y.	y.	PROPN
admet-2874	738	23	wang	wang	PROPN
admet-2874	738	24	,	,	PUNCT
admet-2874	738	25	x.	x.	PROPN
admet-2874	738	26	shuai	shuai	PROPN
admet-2874	738	27	.	.	PUNCT
admet-2874	739	1	retinol	retinol	NOUN
admet-2874	739	2	-	-	PUNCT
admet-2874	739	3	binding	bind	VERB
admet-2874	739	4	protein	protein	NOUN
admet-2874	739	5	-	-	PUNCT
admet-2874	739	6	hijacking	hijack	VERB
admet-2874	739	7	nanopolyplex	nanopolyplex	ADJ
admet-2874	739	8	delivering	deliver	VERB
admet-2874	739	9	sirna	sirna	PROPN
admet-2874	739	10	to	to	ADP
admet-2874	739	11	cytoplasm	cytoplasm	NOUN
admet-2874	739	12	of	of	ADP
admet-2874	739	13	hepatic	hepatic	ADJ
admet-2874	739	14	stellate	stellate	ADJ
admet-2874	739	15	cell	cell	NOUN
admet-2874	739	16	for	for	ADP
admet-2874	739	17	liver	liver	NOUN
admet-2874	739	18	fibrosis	fibrosis	NOUN
admet-2874	739	19	alleviation	alleviation	NOUN
admet-2874	739	20	.	.	PUNCT
admet-2874	740	1	biomaterials	biomaterial	NOUN
admet-2874	740	2	299	299	NUM
admet-2874	740	3	(	(	PUNCT
admet-2874	740	4	2023	2023	NUM
admet-2874	740	5	)	)	PUNCT
admet-2874	740	6	122134	122134	NUM
admet-2874	740	7	.	.	PUNCT
admet-2874	741	1	https://doi.org/10.1016/j.biomaterials.2023.122134	https://doi.org/10.1016/j.biomaterials.2023.122134	PROPN
admet-2874	741	2	120	120	NUM
admet-2874	741	3	.	.	PUNCT
admet-2874	741	4	m.	m.	PROPN
admet-2874	741	5	azzam	azzam	PROPN
admet-2874	741	6	,	,	PUNCT
admet-2874	741	7	s.	s.	PROPN
admet-2874	741	8	el	el	PROPN
admet-2874	741	9	safy	safy	PROPN
admet-2874	741	10	,	,	PUNCT
admet-2874	741	11	s.a	s.a	PROPN
admet-2874	741	12	.	.	PROPN
admet-2874	741	13	abdelgelil	abdelgelil	PROPN
admet-2874	741	14	,	,	PUNCT
admet-2874	741	15	r.	r.	PROPN
admet-2874	741	16	weiskirchen	weiskirchen	PROPN
admet-2874	741	17	,	,	PUNCT
admet-2874	741	18	a.	a.	NOUN
admet-2874	741	19	asimakopoulou	asimakopoulou	PROPN
admet-2874	741	20	,	,	PUNCT
admet-2874	741	21	f.	f.	PROPN
admet-2874	741	22	de	de	PROPN
admet-2874	741	23	lorenzi	lorenzi	PROPN
admet-2874	741	24	,	,	PUNCT
admet-2874	741	25	t.	t.	PROPN
admet-2874	741	26	lammers	lammers	PROPN
admet-2874	741	27	,	,	PUNCT
admet-2874	741	28	s.	s.	PROPN
admet-2874	741	29	mansour	mansour	PROPN
admet-2874	741	30	,	,	PUNCT
admet-2874	741	31	s.	s.	PROPN
admet-2874	741	32	tammam	tammam	PROPN
admet-2874	741	33	.	.	PUNCT
admet-2874	742	1	targeting	target	VERB
admet-2874	742	2	activated	activate	VERB
admet-2874	742	3	hepatic	hepatic	ADJ
admet-2874	742	4	stellate	stellate	ADJ
admet-2874	742	5	cells	cell	NOUN
admet-2874	742	6	using	use	VERB
admet-2874	742	7	collagenbinding	collagenbinde	VERB
admet-2874	742	8	chitosan	chitosan	ADJ
admet-2874	742	9	nanoparticles	nanoparticle	NOUN
admet-2874	742	10	for	for	ADP
admet-2874	742	11	sirna	sirna	PROPN
admet-2874	742	12	delivery	delivery	NOUN
admet-2874	742	13	to	to	ADP
admet-2874	742	14	fibrotic	fibrotic	ADJ
admet-2874	742	15	livers	liver	NOUN
admet-2874	742	16	.	.	PUNCT
admet-2874	743	1	pharmaceutics	pharmaceutic	NOUN
admet-2874	743	2	12(6	12(6	NUM
admet-2874	743	3	)	)	PUNCT
admet-2874	743	4	(	(	PUNCT
admet-2874	743	5	2020	2020	NUM
admet-2874	743	6	)	)	PUNCT
admet-2874	743	7	590	590	NUM
admet-2874	743	8	.	.	PUNCT
admet-2874	743	9	https://doi.org/10.3390/pharmaceutics12060590	https://doi.org/10.3390/pharmaceutics12060590	PROPN
admet-2874	743	10	121	121	NUM
admet-2874	743	11	.	.	PUNCT
admet-2874	744	1	m.a	m.a	PROPN
admet-2874	744	2	.	.	PROPN
admet-2874	744	3	younis	younis	PROPN
admet-2874	744	4	,	,	PUNCT
admet-2874	744	5	y.	y.	PROPN
admet-2874	744	6	sato	sato	PROPN
admet-2874	744	7	,	,	PUNCT
admet-2874	744	8	y.h.a	y.h.a	PROPN
admet-2874	744	9	.	.	PUNCT
admet-2874	744	10	elewa	elewa	PROPN
admet-2874	744	11	,	,	PUNCT
admet-2874	744	12	h.	h.	PROPN
admet-2874	744	13	harashima	harashima	PROPN
admet-2874	744	14	.	.	PUNCT
admet-2874	745	1	reprogramming	reprogramme	VERB
admet-2874	745	2	activated	activate	VERB
admet-2874	745	3	hepatic	hepatic	ADJ
admet-2874	745	4	stellate	stellate	ADJ
admet-2874	745	5	cells	cell	NOUN
admet-2874	745	6	by	by	ADP
admet-2874	745	7	sirna	sirna	PROPN
admet-2874	745	8	-	-	PUNCT
admet-2874	745	9	loaded	load	VERB
admet-2874	745	10	nanocarriers	nanocarrier	NOUN
admet-2874	745	11	reverses	reverse	VERB
admet-2874	745	12	liver	liver	NOUN
admet-2874	745	13	fibrosis	fibrosis	NOUN
admet-2874	745	14	in	in	ADP
admet-2874	745	15	mice	mouse	NOUN
admet-2874	745	16	.	.	PUNCT
admet-2874	746	1	journal	journal	PROPN
admet-2874	746	2	of	of	ADP
admet-2874	746	3	controlled	control	VERB
admet-2874	746	4	release	release	NOUN
admet-2874	746	5	361	361	NUM
admet-2874	746	6	(	(	PUNCT
admet-2874	746	7	2023	2023	NUM
admet-2874	746	8	)	)	PUNCT
admet-2874	746	9	592	592	NUM
admet-2874	746	10	-	-	SYM
admet-2874	746	11	603	603	NUM
admet-2874	746	12	.	.	PUNCT
admet-2874	747	1	https://doi.org/10.1016/j.jconrel.2023.08.021	https://doi.org/10.1016/j.jconrel.2023.08.021	NUM
admet-2874	747	2	122	122	NUM
admet-2874	747	3	.	.	PUNCT
admet-2874	748	1	m.x	m.x	PROPN
admet-2874	748	2	.	.	PROPN
admet-2874	748	3	liu	liu	PROPN
admet-2874	748	4	,	,	PUNCT
admet-2874	748	5	l.	l.	PROPN
admet-2874	748	6	xu	xu	PROPN
admet-2874	748	7	,	,	PUNCT
admet-2874	748	8	y.t	y.t	PROPN
admet-2874	748	9	.	.	PROPN
admet-2874	748	10	cai	cai	PROPN
admet-2874	748	11	,	,	PUNCT
admet-2874	748	12	r.j	r.j	PROPN
admet-2874	748	13	.	.	PROPN
admet-2874	748	14	wang	wang	PROPN
admet-2874	748	15	,	,	PUNCT
admet-2874	748	16	y.y	y.y	PROPN
admet-2874	748	17	.	.	PROPN
admet-2874	748	18	gu	gu	PROPN
admet-2874	748	19	,	,	PUNCT
admet-2874	748	20	y.c	y.c	PROPN
admet-2874	748	21	.	.	PROPN
admet-2874	748	22	liu	liu	PROPN
admet-2874	748	23	,	,	PUNCT
admet-2874	748	24	y.j	y.j	PROPN
admet-2874	748	25	.	.	PUNCT
admet-2874	749	1	zou	zou	PROPN
admet-2874	749	2	,	,	PUNCT
admet-2874	749	3	y.m	y.m	PROPN
admet-2874	749	4	.	.	PROPN
admet-2874	749	5	zhao	zhao	PROPN
admet-2874	749	6	,	,	PUNCT
admet-2874	749	7	j.	j.	PROPN
admet-2874	749	8	chen	chen	PROPN
admet-2874	749	9	,	,	PUNCT
admet-2874	750	1	x.l	x.l	PROPN
admet-2874	750	2	.	.	PROPN
admet-2874	750	3	zhang	zhang	PROPN
admet-2874	750	4	.	.	PUNCT
admet-2874	751	1	carbon	carbon	PROPN
admet-2874	751	2	nitride	nitride	NOUN
admet-2874	751	3	-	-	PUNCT
admet-2874	751	4	based	base	VERB
admet-2874	751	5	sirna	sirna	PROPN
admet-2874	751	6	vectors	vector	NOUN
admet-2874	751	7	with	with	ADP
admet-2874	751	8	self	self	NOUN
admet-2874	751	9	-	-	PUNCT
admet-2874	751	10	produced	produce	VERB
admet-2874	751	11	o(2	o(2	PROPN
admet-2874	751	12	)	)	PUNCT
admet-2874	751	13	effects	effect	NOUN
admet-2874	751	14	for	for	ADP
admet-2874	751	15	targeting	target	VERB
admet-2874	751	16	combination	combination	NOUN
admet-2874	751	17	therapy	therapy	NOUN
admet-2874	751	18	of	of	ADP
admet-2874	751	19	liver	liver	NOUN
admet-2874	751	20	fibrosis	fibrosis	NOUN
admet-2874	751	21	via	via	ADP
admet-2874	751	22	hif-1α	hif-1α	NOUN
admet-2874	751	23	-	-	PUNCT
admet-2874	751	24	mediated	mediate	VERB
admet-2874	751	25	tgf	tgf	NOUN
admet-2874	751	26	-	-	PUNCT
admet-2874	751	27	β1	β1	PROPN
admet-2874	751	28	/	/	SYM
admet-2874	751	29	smad	smad	PROPN
admet-2874	751	30	pathway	pathway	NOUN
admet-2874	751	31	.	.	PUNCT
admet-2874	752	1	advanced	advanced	ADJ
admet-2874	752	2	healthcare	healthcare	NOUN
admet-2874	752	3	materials	material	NOUN
admet-2874	752	4	12	12	NUM
admet-2874	752	5	(	(	PUNCT
admet-2874	752	6	2023	2023	NUM
admet-2874	752	7	)	)	PUNCT
admet-2874	752	8	e2301485	e2301485	NOUN
admet-2874	752	9	.	.	PUNCT
admet-2874	752	10	https://doi.org/10.1002/adhm.202301485	https://doi.org/10.1002/adhm.202301485	PROPN
admet-2874	752	11	123	123	NUM
admet-2874	752	12	.	.	PUNCT
admet-2874	753	1	l.	l.	PROPN
admet-2874	753	2	wang	wang	PROPN
admet-2874	753	3	,	,	PUNCT
admet-2874	753	4	j.	j.	PROPN
admet-2874	753	5	zhou	zhou	PROPN
admet-2874	753	6	,	,	PUNCT
admet-2874	753	7	j.	j.	PROPN
admet-2874	753	8	wang	wang	PROPN
admet-2874	753	9	,	,	PUNCT
admet-2874	753	10	x.	x.	PROPN
admet-2874	753	11	wang	wang	PROPN
admet-2874	753	12	,	,	PUNCT
admet-2874	753	13	h.	h.	PROPN
admet-2874	753	14	dong	dong	PROPN
admet-2874	753	15	,	,	PUNCT
admet-2874	753	16	l.	l.	PROPN
admet-2874	753	17	zhao	zhao	PROPN
admet-2874	753	18	,	,	PUNCT
admet-2874	753	19	j.	j.	PROPN
admet-2874	753	20	wu	wu	PROPN
admet-2874	753	21	,	,	PUNCT
admet-2874	753	22	j.	j.	PROPN
admet-2874	753	23	peng	peng	PROPN
admet-2874	753	24	.	.	PUNCT
admet-2874	754	1	hepatic	hepatic	ADJ
admet-2874	754	2	stellate	stellate	ADJ
admet-2874	754	3	celltargeting	celltargete	VERB
admet-2874	754	4	micelle	micelle	NOUN
admet-2874	754	5	nanomedicine	nanomedicine	NOUN
admet-2874	754	6	for	for	ADP
admet-2874	754	7	early	early	ADJ
admet-2874	754	8	diagnosis	diagnosis	NOUN
admet-2874	754	9	and	and	CCONJ
admet-2874	754	10	treatment	treatment	NOUN
admet-2874	754	11	of	of	ADP
admet-2874	754	12	liver	liver	NOUN
admet-2874	754	13	fibrosis	fibrosis	NOUN
admet-2874	754	14	.	.	PUNCT
admet-2874	755	1	advanced	advanced	ADJ
admet-2874	755	2	healthcare	healthcare	NOUN
admet-2874	755	3	materials	material	NOUN
admet-2874	755	4	13(12	13(12	NUM
admet-2874	755	5	)	)	PUNCT
admet-2874	755	6	(	(	PUNCT
admet-2874	755	7	2024	2024	NUM
admet-2874	755	8	)	)	PUNCT
admet-2874	755	9	2303710	2303710	NUM
admet-2874	755	10	.	.	PUNCT
admet-2874	756	1	https://doi.org/10.1002/adhm.202303710	https://doi.org/10.1002/adhm.202303710	NOUN
admet-2874	756	2	124	124	NUM
admet-2874	756	3	.	.	PUNCT
admet-2874	757	1	y.n	y.n	PROPN
admet-2874	757	2	.	.	PROPN
admet-2874	757	3	chen	chen	PROPN
admet-2874	757	4	,	,	PUNCT
admet-2874	757	5	s.l	s.l	PROPN
admet-2874	757	6	.	.	PROPN
admet-2874	757	7	hsu	hsu	PROPN
admet-2874	757	8	,	,	PUNCT
admet-2874	757	9	m.y	m.y	PROPN
admet-2874	757	10	.	.	PROPN
admet-2874	757	11	liao	liao	PROPN
admet-2874	757	12	,	,	PUNCT
admet-2874	757	13	y.t	y.t	PROPN
admet-2874	757	14	.	.	PROPN
admet-2874	758	1	liu	liu	PROPN
admet-2874	758	2	,	,	PUNCT
admet-2874	758	3	c.h	c.h	PROPN
admet-2874	758	4	.	.	PROPN
admet-2874	758	5	lai	lai	PROPN
admet-2874	758	6	,	,	PUNCT
admet-2874	758	7	j.f	j.f	PROPN
admet-2874	758	8	.	.	PROPN
admet-2874	758	9	chen	chen	PROPN
admet-2874	758	10	,	,	PUNCT
admet-2874	758	11	m.h.t	m.h.t	PROPN
admet-2874	758	12	.	.	PUNCT
admet-2874	758	13	nguyen	nguyen	PROPN
admet-2874	758	14	,	,	PUNCT
admet-2874	758	15	y.h.su	y.h.su	PROPN
admet-2874	758	16	,	,	PUNCT
admet-2874	758	17	s.t	s.t	PROPN
admet-2874	758	18	.	.	PROPN
admet-2874	758	19	chen	chen	PROPN
admet-2874	758	20	,	,	PUNCT
admet-2874	758	21	l.c	l.c	PROPN
admet-2874	758	22	.	.	PROPN
admet-2874	758	23	wu	wu	PROPN
admet-2874	758	24	.	.	PUNCT
admet-2874	759	1	ameliorative	ameliorative	ADJ
admet-2874	759	2	effect	effect	NOUN
admet-2874	759	3	of	of	ADP
admet-2874	759	4	curcumin	curcumin	NOUN
admet-2874	759	5	-	-	PUNCT
admet-2874	759	6	encapsulated	encapsulate	VERB
admet-2874	759	7	hyaluronic	hyaluronic	ADJ
admet-2874	759	8	acid	acid	NOUN
admet-2874	759	9	-	-	PUNCT
admet-2874	759	10	pla	pla	NOUN
admet-2874	759	11	nanoparticles	nanoparticle	NOUN
admet-2874	759	12	on	on	ADP
admet-2874	759	13	thioacetamide	thioacetamide	ADV
admet-2874	759	14	-	-	PUNCT
admet-2874	759	15	induced	induce	VERB
admet-2874	759	16	murine	murine	ADJ
admet-2874	759	17	hepatic	hepatic	ADJ
admet-2874	759	18	fibrosis	fibrosis	NOUN
admet-2874	759	19	.	.	PUNCT
admet-2874	760	1	international	international	ADJ
admet-2874	760	2	journal	journal	PROPN
admet-2874	760	3	of	of	ADP
admet-2874	760	4	environmental	environmental	ADJ
admet-2874	760	5	research	research	NOUN
admet-2874	760	6	and	and	CCONJ
admet-2874	760	7	public	public	ADJ
admet-2874	760	8	health	health	NOUN
admet-2874	760	9	14(1	14(1	NUM
admet-2874	760	10	)	)	PUNCT
admet-2874	760	11	(	(	PUNCT
admet-2874	760	12	2017	2017	NUM
admet-2874	760	13	)	)	PUNCT
admet-2874	760	14	11	11	NUM
admet-2874	760	15	.	.	PUNCT
admet-2874	761	1	https://doi.org/10.3390/ijerph14010011	https://doi.org/10.3390/ijerph14010011	PROPN
admet-2874	761	2	125	125	NUM
admet-2874	761	3	.	.	PUNCT
admet-2874	762	1	y.	y.	PROPN
admet-2874	762	2	liu	liu	PROPN
admet-2874	762	3	,	,	PUNCT
admet-2874	762	4	s.	s.	PROPN
admet-2874	762	5	chen	chen	PROPN
admet-2874	762	6	,	,	PUNCT
admet-2874	762	7	h.	h.	PROPN
admet-2874	762	8	huang	huang	PROPN
admet-2874	762	9	,	,	PUNCT
admet-2874	762	10	a.c	a.c	PROPN
admet-2874	762	11	.	.	PROPN
admet-2874	762	12	midgley	midgley	PROPN
admet-2874	762	13	,	,	PUNCT
admet-2874	762	14	z.	z.	PROPN
admet-2874	762	15	han	han	PROPN
admet-2874	762	16	,	,	PUNCT
admet-2874	762	17	z.c	z.c	PROPN
admet-2874	762	18	.	.	PROPN
admet-2874	762	19	han	han	PROPN
admet-2874	762	20	,	,	PUNCT
admet-2874	762	21	q.	q.	PROPN
admet-2874	762	22	li	li	PROPN
admet-2874	762	23	,	,	PUNCT
admet-2874	762	24	z.	z.	PROPN
admet-2874	762	25	li	li	PROPN
admet-2874	762	26	.	.	PROPN
admet-2874	762	27	ligand	ligand	NOUN
admet-2874	762	28	-	-	PUNCT
admet-2874	762	29	tethered	tether	VERB
admet-2874	762	30	extracellular	extracellular	ADJ
admet-2874	762	31	vesicles	vesicle	NOUN
admet-2874	762	32	mediated	mediate	VERB
admet-2874	762	33	rna	rna	NOUN
admet-2874	762	34	therapy	therapy	NOUN
admet-2874	762	35	for	for	ADP
admet-2874	762	36	liver	liver	NOUN
admet-2874	762	37	fibrosis	fibrosis	NOUN
admet-2874	762	38	.	.	PUNCT
admet-2874	763	1	advanced	advanced	ADJ
admet-2874	763	2	healthcare	healthcare	NOUN
admet-2874	763	3	materials	material	NOUN
admet-2874	763	4	14	14	NUM
admet-2874	763	5	(	(	PUNCT
admet-2874	763	6	2025	2025	NUM
admet-2874	763	7	)	)	PUNCT
admet-2874	763	8	2403068	2403068	NUM
admet-2874	763	9	.	.	PUNCT
admet-2874	764	1	https://doi.org/10.1002/adhm.202403068	https://doi.org/10.1002/adhm.202403068	VERB
admet-2874	764	2	126	126	NUM
admet-2874	764	3	.	.	PUNCT
admet-2874	765	1	w.	w.	PROPN
admet-2874	765	2	li	li	PROPN
admet-2874	765	3	,	,	PUNCT
admet-2874	765	4	c.	c.	PROPN
admet-2874	765	5	zhou	zhou	PROPN
admet-2874	765	6	,	,	PUNCT
admet-2874	765	7	y.	y.	PROPN
admet-2874	765	8	fu	fu	PROPN
admet-2874	765	9	,	,	PUNCT
admet-2874	765	10	t.	t.	PROPN
admet-2874	765	11	chen	chen	PROPN
admet-2874	765	12	,	,	PUNCT
admet-2874	765	13	x.	x.	PROPN
admet-2874	765	14	liu	liu	PROPN
admet-2874	765	15	,	,	PUNCT
admet-2874	765	16	z.	z.	PROPN
admet-2874	765	17	zhang	zhang	PROPN
admet-2874	765	18	,	,	PUNCT
admet-2874	765	19	t.	t.	PROPN
admet-2874	765	20	gong	gong	PROPN
admet-2874	765	21	.	.	PUNCT
admet-2874	766	1	targeted	target	VERB
admet-2874	766	2	delivery	delivery	NOUN
admet-2874	766	3	of	of	ADP
admet-2874	766	4	hyaluronic	hyaluronic	ADJ
admet-2874	766	5	acid	acid	NOUN
admet-2874	766	6	nanomicelles	nanomicelle	NOUN
admet-2874	766	7	to	to	ADP
admet-2874	766	8	hepatic	hepatic	ADJ
admet-2874	766	9	stellate	stellate	ADJ
admet-2874	766	10	cells	cell	NOUN
admet-2874	766	11	in	in	ADP
admet-2874	766	12	hepatic	hepatic	ADJ
admet-2874	766	13	fibrosis	fibrosis	NOUN
admet-2874	766	14	rats	rat	NOUN
admet-2874	766	15	.	.	PUNCT
admet-2874	767	1	acta	acta	PROPN
admet-2874	767	2	pharmaceutica	pharmaceutica	PROPN
admet-2874	767	3	sinica	sinica	PROPN
admet-2874	767	4	b	b	PROPN
admet-2874	767	5	10	10	NUM
admet-2874	767	6	(	(	PUNCT
admet-2874	767	7	2020	2020	NUM
admet-2874	767	8	)	)	PUNCT
admet-2874	767	9	693	693	NUM
admet-2874	767	10	-	-	SYM
admet-2874	767	11	710	710	NUM
admet-2874	767	12	.	.	PUNCT
admet-2874	768	1	https://doi.org/10.1016/j.apsb.2019.07.003	https://doi.org/10.1016/j.apsb.2019.07.003	PROPN
admet-2874	768	2	https://doi.org/10.1016/j.intimp.2025.114209	https://doi.org/10.1016/j.intimp.2025.114209	PROPN
admet-2874	768	3	https://doi.org/10.1016/j.ejphar.2024.176629	https://doi.org/10.1016/j.ejphar.2024.176629	PROPN
admet-2874	768	4	https://doi.org/10.1016/j.biomaterials.2025.123295	https://doi.org/10.1016/j.biomaterials.2025.123295	NOUN
admet-2874	768	5	https://doi.org/10.1016/j.nantod.2025.102641	https://doi.org/10.1016/j.nantod.2025.102641	PROPN
admet-2874	768	6	https://doi.org/10.1021/acsnano.4c15562	https://doi.org/10.1021/acsnano.4c15562	ADJ
admet-2874	768	7	https://doi.org/10.1016/j.biomaterials.2023.122134	https://doi.org/10.1016/j.biomaterials.2023.122134	PROPN
admet-2874	768	8	https://doi.org/10.3390/pharmaceutics12060590	https://doi.org/10.3390/pharmaceutics12060590	PROPN
admet-2874	768	9	https://doi.org/10.1002/adhm.202301485	https://doi.org/10.1002/adhm.202301485	PROPN
admet-2874	768	10	https://doi.org/10.1002/adhm.202303710	https://doi.org/10.1002/adhm.202303710	NOUN
admet-2874	768	11	https://doi.org/10.3390/ijerph14010011	https://doi.org/10.3390/ijerph14010011	NOUN
admet-2874	768	12	https://doi.org/10.1002/adhm.202403068	https://doi.org/10.1002/adhm.202403068	VERB
admet-2874	768	13	https://doi.org/10.1016/j.apsb.2019.07.003	https://doi.org/10.1016/j.apsb.2019.07.003	PROPN
admet-2874	768	14	admet	admet	PROPN
admet-2874	768	15	&	&	CCONJ
admet-2874	768	16	dmpk	dmpk	PROPN
admet-2874	768	17	13(4	13(4	NUM
admet-2874	768	18	)	)	PUNCT
admet-2874	768	19	(	(	PUNCT
admet-2874	768	20	2025	2025	NUM
admet-2874	768	21	)	)	PUNCT
admet-2874	768	22	2874	2874	NUM
admet-2874	768	23	hscs	hsc	NOUN
admet-2874	768	24	in	in	ADP
admet-2874	768	25	liver	liver	NOUN
admet-2874	768	26	fibrosis	fibrosis	NOUN
admet-2874	768	27	:	:	PUNCT
admet-2874	768	28	therapeutic	therapeutic	ADJ
admet-2874	768	29	advances	advance	NOUN
admet-2874	768	30	doi	doi	NOUN
admet-2874	768	31	:	:	PUNCT
admet-2874	768	32	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PROPN
admet-2874	768	33	25	25	NUM
admet-2874	768	34	127	127	NUM
admet-2874	768	35	.	.	PUNCT
admet-2874	769	1	x.	x.	PROPN
admet-2874	769	2	wang	wang	PROPN
admet-2874	769	3	,	,	PUNCT
admet-2874	769	4	w.	w.	PROPN
admet-2874	769	5	zhang	zhang	PROPN
admet-2874	769	6	,	,	PUNCT
admet-2874	769	7	s.	s.	PROPN
admet-2874	769	8	zeng	zeng	PROPN
admet-2874	769	9	,	,	PUNCT
admet-2874	769	10	l.	l.	PROPN
admet-2874	769	11	wang	wang	PROPN
admet-2874	769	12	,	,	PUNCT
admet-2874	769	13	b.	b.	PROPN
admet-2874	769	14	wang	wang	PROPN
admet-2874	769	15	.	.	PUNCT
admet-2874	770	1	collagenase	collagenase	PROPN
admet-2874	770	2	type	type	PROPN
admet-2874	770	3	i	i	PROPN
admet-2874	770	4	and	and	CCONJ
admet-2874	770	5	probucol	probucol	NOUN
admet-2874	770	6	-	-	PUNCT
admet-2874	770	7	loaded	load	VERB
admet-2874	770	8	nanoparticles	nanoparticle	NOUN
admet-2874	770	9	penetrate	penetrate	VERB
admet-2874	770	10	the	the	DET
admet-2874	770	11	extracellular	extracellular	ADJ
admet-2874	770	12	matrix	matrix	NOUN
admet-2874	770	13	to	to	PART
admet-2874	770	14	target	target	VERB
admet-2874	770	15	hepatic	hepatic	ADJ
admet-2874	770	16	stellate	stellate	ADJ
admet-2874	770	17	cells	cell	NOUN
admet-2874	770	18	for	for	ADP
admet-2874	770	19	hepatic	hepatic	ADJ
admet-2874	770	20	fibrosis	fibrosis	NOUN
admet-2874	770	21	therapy	therapy	NOUN
admet-2874	770	22	.	.	PUNCT
admet-2874	771	1	acta	acta	PROPN
admet-2874	771	2	biomaterialia	biomaterialia	PROPN
admet-2874	771	3	175	175	NUM
admet-2874	771	4	(	(	PUNCT
admet-2874	771	5	2024	2024	NUM
admet-2874	771	6	)	)	PUNCT
admet-2874	771	7	262	262	NUM
admet-2874	771	8	-	-	SYM
admet-2874	771	9	278	278	NUM
admet-2874	771	10	.	.	PUNCT
admet-2874	772	1	https://doi.org/10.1016/j.actbio.2023.12.027	https://doi.org/10.1016/j.actbio.2023.12.027	PROPN
admet-2874	772	2	128	128	NUM
admet-2874	772	3	.	.	PUNCT
admet-2874	773	1	y.	y.	PROPN
admet-2874	773	2	xiong	xiong	PROPN
admet-2874	773	3	,	,	PUNCT
admet-2874	773	4	b.	b.	PROPN
admet-2874	773	5	wu	wu	PROPN
admet-2874	773	6	,	,	PUNCT
admet-2874	773	7	x.	x.	PROPN
admet-2874	773	8	guo	guo	PROPN
admet-2874	773	9	,	,	PUNCT
admet-2874	773	10	d.	d.	PROPN
admet-2874	773	11	shi	shi	PROPN
admet-2874	773	12	,	,	PUNCT
admet-2874	773	13	h.	h.	PROPN
admet-2874	773	14	xia	xia	PROPN
admet-2874	773	15	,	,	PUNCT
admet-2874	773	16	h.	h.	PROPN
admet-2874	773	17	xu	xu	PROPN
admet-2874	773	18	,	,	PUNCT
admet-2874	774	1	x.	x.	PROPN
admet-2874	774	2	liu	liu	PROPN
admet-2874	774	3	.	.	PUNCT
admet-2874	775	1	galangin	galangin	PROPN
admet-2874	775	2	delivered	deliver	VERB
admet-2874	775	3	by	by	ADP
admet-2874	775	4	retinoic	retinoic	ADJ
admet-2874	775	5	acid	acid	NOUN
admet-2874	775	6	-	-	PUNCT
admet-2874	775	7	modified	modify	VERB
admet-2874	775	8	nanoparticles	nanoparticle	NOUN
admet-2874	775	9	targeted	target	VERB
admet-2874	775	10	hepatic	hepatic	ADJ
admet-2874	775	11	stellate	stellate	ADJ
admet-2874	775	12	cells	cell	NOUN
admet-2874	775	13	for	for	ADP
admet-2874	775	14	the	the	DET
admet-2874	775	15	treatment	treatment	NOUN
admet-2874	775	16	of	of	ADP
admet-2874	775	17	hepatic	hepatic	ADJ
admet-2874	775	18	fibrosis	fibrosis	NOUN
admet-2874	775	19	.	.	PUNCT
admet-2874	776	1	rsc	rsc	PROPN
admet-2874	776	2	advances	advance	VERB
admet-2874	776	3	13	13	NUM
admet-2874	776	4	(	(	PUNCT
admet-2874	776	5	2023	2023	NUM
admet-2874	776	6	)	)	PUNCT
admet-2874	776	7	10987	10987	NUM
admet-2874	776	8	-	-	SYM
admet-2874	776	9	11001	11001	NUM
admet-2874	776	10	.	.	PUNCT
admet-2874	777	1	https://doi.org/10.1039/d2ra07561j	https://doi.org/10.1039/d2ra07561j	PROPN
admet-2874	777	2	129	129	NUM
admet-2874	777	3	.	.	PUNCT
admet-2874	778	1	y.	y.	PROPN
admet-2874	778	2	li	li	PROPN
admet-2874	778	3	,	,	PUNCT
admet-2874	778	4	s.	s.	PROPN
admet-2874	778	5	pu	pu	PROPN
admet-2874	778	6	,	,	PUNCT
admet-2874	778	7	q.	q.	PROPN
admet-2874	778	8	liu	liu	PROPN
admet-2874	778	9	,	,	PUNCT
admet-2874	778	10	r.	r.	PROPN
admet-2874	778	11	li	li	PROPN
admet-2874	778	12	,	,	PUNCT
admet-2874	778	13	j.	j.	PROPN
admet-2874	778	14	zhang	zhang	PROPN
admet-2874	778	15	,	,	PUNCT
admet-2874	778	16	t.	t.	PROPN
admet-2874	778	17	wu	wu	PROPN
admet-2874	778	18	,	,	PUNCT
admet-2874	778	19	l.	l.	PROPN
admet-2874	778	20	chen	chen	PROPN
admet-2874	778	21	,	,	PUNCT
admet-2874	778	22	h.	h.	PROPN
admet-2874	778	23	li	li	PROPN
admet-2874	778	24	,	,	PUNCT
admet-2874	778	25	x.	x.	PROPN
admet-2874	778	26	yang	yang	PROPN
admet-2874	778	27	,	,	PUNCT
admet-2874	778	28	m.	m.	PROPN
admet-2874	778	29	zou	zou	PROPN
admet-2874	778	30	,	,	PUNCT
admet-2874	778	31	j.	j.	PROPN
admet-2874	778	32	xiao	xiao	PROPN
admet-2874	778	33	,	,	PUNCT
admet-2874	778	34	w.	w.	PROPN
admet-2874	778	35	xie	xie	PROPN
admet-2874	778	36	,	,	PUNCT
admet-2874	778	37	j.	j.	PROPN
admet-2874	778	38	he	he	PROPN
admet-2874	778	39	.	.	PUNCT
admet-2874	779	1	an	an	DET
admet-2874	779	2	integrin	integrin	NOUN
admet-2874	779	3	-	-	PUNCT
admet-2874	779	4	based	base	VERB
admet-2874	779	5	nanoparticle	nanoparticle	NOUN
admet-2874	779	6	that	that	PRON
admet-2874	779	7	targets	target	VERB
admet-2874	779	8	activated	activate	VERB
admet-2874	779	9	hepatic	hepatic	ADJ
admet-2874	779	10	stellate	stellate	ADJ
admet-2874	779	11	cells	cell	NOUN
admet-2874	779	12	and	and	CCONJ
admet-2874	779	13	alleviates	alleviate	VERB
admet-2874	779	14	liver	liver	NOUN
admet-2874	779	15	fibrosis	fibrosis	NOUN
admet-2874	779	16	.	.	PUNCT
admet-2874	780	1	journal	journal	PROPN
admet-2874	780	2	of	of	ADP
admet-2874	780	3	controlled	control	VERB
admet-2874	780	4	release	release	NOUN
admet-2874	780	5	303	303	NUM
admet-2874	780	6	(	(	PUNCT
admet-2874	780	7	2019	2019	NUM
admet-2874	780	8	)	)	PUNCT
admet-2874	780	9	77	77	NUM
admet-2874	780	10	-	-	SYM
admet-2874	780	11	90	90	NUM
admet-2874	780	12	.	.	PUNCT
admet-2874	781	1	https://doi.org/10.1016/j.jconrel.2019.04.022	https://doi.org/10.1016/j.jconrel.2019.04.022	PROPN
admet-2874	781	2	130	130	NUM
admet-2874	781	3	.	.	PUNCT
admet-2874	782	1	r.	r.	PROPN
admet-2874	782	2	li	li	PROPN
admet-2874	782	3	,	,	PUNCT
admet-2874	782	4	j.	j.	PROPN
admet-2874	782	5	zhang	zhang	PROPN
admet-2874	782	6	,	,	PUNCT
admet-2874	782	7	q.	q.	PROPN
admet-2874	782	8	liu	liu	PROPN
admet-2874	782	9	,	,	PUNCT
admet-2874	782	10	q.	q.	PROPN
admet-2874	782	11	tang	tang	PROPN
admet-2874	782	12	,	,	PUNCT
admet-2874	782	13	q.	q.	PROPN
admet-2874	782	14	jia	jia	PROPN
admet-2874	782	15	,	,	PUNCT
admet-2874	782	16	y.	y.	PROPN
admet-2874	782	17	xiong	xiong	PROPN
admet-2874	782	18	,	,	PUNCT
admet-2874	782	19	j.	j.	PROPN
admet-2874	782	20	he	he	PROPN
admet-2874	782	21	,	,	PUNCT
admet-2874	782	22	y.	y.	PROPN
admet-2874	782	23	li	li	PROPN
admet-2874	782	24	.	.	PROPN
admet-2874	782	25	creka	creka	PROPN
admet-2874	782	26	-	-	PUNCT
admet-2874	782	27	modified	modify	VERB
admet-2874	782	28	liposomes	liposome	NOUN
admet-2874	782	29	target	target	VERB
admet-2874	782	30	activated	activate	VERB
admet-2874	782	31	hepatic	hepatic	ADJ
admet-2874	782	32	stellate	stellate	ADJ
admet-2874	782	33	cells	cell	NOUN
admet-2874	782	34	to	to	PART
admet-2874	782	35	alleviate	alleviate	VERB
admet-2874	782	36	liver	liver	NOUN
admet-2874	782	37	fibrosis	fibrosis	NOUN
admet-2874	782	38	by	by	ADP
admet-2874	782	39	inhibiting	inhibit	VERB
admet-2874	782	40	collagen	collagen	NOUN
admet-2874	782	41	synthesis	synthesis	NOUN
admet-2874	782	42	and	and	CCONJ
admet-2874	782	43	angiogenesis	angiogenesis	NOUN
admet-2874	782	44	.	.	PUNCT
admet-2874	783	1	acta	acta	PROPN
admet-2874	783	2	biomaterialia	biomaterialia	PROPN
admet-2874	783	3	168	168	NUM
admet-2874	783	4	(	(	PUNCT
admet-2874	783	5	2023	2023	NUM
admet-2874	783	6	)	)	PUNCT
admet-2874	783	7	484	484	NUM
admet-2874	783	8	-	-	SYM
admet-2874	783	9	496	496	NUM
admet-2874	783	10	.	.	PUNCT
admet-2874	784	1	https://doi.org/10.1016/j.actbio.2023.06.032	https://doi.org/10.1016/j.actbio.2023.06.032	PROPN
admet-2874	784	2	131	131	NUM
admet-2874	784	3	.	.	PUNCT
admet-2874	785	1	y.	y.	PROPN
admet-2874	785	2	zhang	zhang	PROPN
admet-2874	785	3	,	,	PUNCT
admet-2874	785	4	y.	y.	PROPN
admet-2874	785	5	li	li	PROPN
admet-2874	785	6	,	,	PUNCT
admet-2874	785	7	t.	t.	PROPN
admet-2874	785	8	mu	mu	PROPN
admet-2874	785	9	,	,	PUNCT
admet-2874	785	10	n.	n.	PROPN
admet-2874	785	11	tong	tong	PROPN
admet-2874	785	12	,	,	PUNCT
admet-2874	785	13	p.	p.	PROPN
admet-2874	785	14	cheng	cheng	PROPN
admet-2874	785	15	.	.	PUNCT
admet-2874	786	1	hepatic	hepatic	ADJ
admet-2874	786	2	stellate	stellate	ADJ
admet-2874	786	3	cells	cell	NOUN
admet-2874	786	4	specific	specific	ADJ
admet-2874	786	5	liposomes	liposome	NOUN
admet-2874	786	6	with	with	ADP
admet-2874	786	7	the	the	DET
admet-2874	786	8	tolllike	tolllike	ADJ
admet-2874	786	9	receptor	receptor	NOUN
admet-2874	786	10	4	4	NUM
admet-2874	786	11	shrna	shrna	ADJ
admet-2874	786	12	attenuates	attenuate	VERB
admet-2874	786	13	liver	liver	NOUN
admet-2874	786	14	fibrosis	fibrosis	NOUN
admet-2874	786	15	.	.	PUNCT
admet-2874	787	1	journal	journal	NOUN
admet-2874	787	2	of	of	ADP
admet-2874	787	3	cellular	cellular	ADJ
admet-2874	787	4	and	and	CCONJ
admet-2874	787	5	molecular	molecular	ADJ
admet-2874	787	6	medicine	medicine	NOUN
admet-2874	787	7	25	25	NUM
admet-2874	787	8	(	(	PUNCT
admet-2874	787	9	2021	2021	NUM
admet-2874	787	10	)	)	PUNCT
admet-2874	787	11	1299	1299	NUM
admet-2874	787	12	-	-	SYM
admet-2874	787	13	1313	1313	NUM
admet-2874	787	14	.	.	PUNCT
admet-2874	788	1	https://doi.org/10.1111/jcmm.16209	https://doi.org/10.1111/jcmm.16209	NOUN
admet-2874	788	2	132	132	NUM
admet-2874	788	3	.	.	PUNCT
admet-2874	789	1	n.s	n.s	PROPN
admet-2874	789	2	.	.	PROPN
admet-2874	789	3	el	el	PROPN
admet-2874	789	4	-	-	PUNCT
admet-2874	789	5	mezayen	mezayen	NOUN
admet-2874	789	6	,	,	PUNCT
admet-2874	789	7	w.f	w.f	PROPN
admet-2874	789	8	.	.	PROPN
admet-2874	789	9	el	el	PROPN
admet-2874	789	10	-	-	PUNCT
admet-2874	789	11	hadidy	hadidy	NOUN
admet-2874	789	12	,	,	PUNCT
admet-2874	789	13	w.m	w.m	PROPN
admet-2874	789	14	.	.	PROPN
admet-2874	790	1	el	el	PROPN
admet-2874	790	2	-	-	PUNCT
admet-2874	790	3	refaie	refaie	NOUN
admet-2874	790	4	,	,	PUNCT
admet-2874	790	5	th.i	th.i	NOUN
admet-2874	790	6	.	.	PUNCT
admet-2874	791	1	shalaby	shalaby	PROPN
admet-2874	791	2	,	,	PUNCT
admet-2874	791	3	m.m	m.m	PROPN
admet-2874	791	4	.	.	PROPN
admet-2874	791	5	khattab	khattab	PROPN
admet-2874	791	6	,	,	PUNCT
admet-2874	791	7	a.s	a.s	PROPN
admet-2874	791	8	.	.	PROPN
admet-2874	791	9	el	el	PROPN
admet-2874	791	10	-	-	PUNCT
admet-2874	791	11	khatib	khatib	PROPN
admet-2874	791	12	.	.	PUNCT
admet-2874	792	1	hepatic	hepatic	ADJ
admet-2874	792	2	stellate	stellate	ADJ
admet-2874	792	3	cell	cell	NOUN
admet-2874	792	4	-	-	PUNCT
admet-2874	792	5	targeted	target	VERB
admet-2874	792	6	imatinib	imatinib	NOUN
admet-2874	792	7	nanomedicine	nanomedicine	ADJ
admet-2874	792	8	versus	versus	ADP
admet-2874	792	9	conventional	conventional	ADJ
admet-2874	792	10	imatinib	imatinib	NOUN
admet-2874	792	11	:	:	PUNCT
admet-2874	792	12	a	a	DET
admet-2874	792	13	novel	novel	ADJ
admet-2874	792	14	strategy	strategy	NOUN
admet-2874	792	15	with	with	ADP
admet-2874	792	16	potent	potent	ADJ
admet-2874	792	17	efficacy	efficacy	NOUN
admet-2874	792	18	in	in	ADP
admet-2874	792	19	experimental	experimental	ADJ
admet-2874	792	20	liver	liver	NOUN
admet-2874	792	21	fibrosis	fibrosis	NOUN
admet-2874	792	22	.	.	PUNCT
admet-2874	793	1	journal	journal	PROPN
admet-2874	793	2	of	of	ADP
admet-2874	793	3	controlled	control	VERB
admet-2874	793	4	release	release	NOUN
admet-2874	793	5	266	266	NUM
admet-2874	793	6	(	(	PUNCT
admet-2874	793	7	2017	2017	NUM
admet-2874	793	8	)	)	PUNCT
admet-2874	793	9	226	226	NUM
admet-2874	793	10	-	-	SYM
admet-2874	793	11	237	237	NUM
admet-2874	793	12	.	.	PUNCT
admet-2874	794	1	https://doi.org/10.1016/j.jconrel.2017.09.035	https://doi.org/10.1016/j.jconrel.2017.09.035	ADP
admet-2874	794	2	133	133	NUM
admet-2874	794	3	.	.	PUNCT
admet-2874	795	1	y.	y.	PROPN
admet-2874	795	2	hao	hao	PROPN
admet-2874	795	3	,	,	PUNCT
admet-2874	795	4	k.	k.	PROPN
admet-2874	795	5	song	song	PROPN
admet-2874	795	6	,	,	PUNCT
admet-2874	795	7	x.	x.	PROPN
admet-2874	795	8	tan	tan	PROPN
admet-2874	795	9	,	,	PUNCT
admet-2874	795	10	l.	l.	PROPN
admet-2874	795	11	ren	ren	PROPN
admet-2874	795	12	,	,	PUNCT
admet-2874	795	13	x.	x.	PROPN
admet-2874	795	14	guo	guo	PROPN
admet-2874	795	15	,	,	PUNCT
admet-2874	795	16	c.	c.	PROPN
admet-2874	795	17	zhou	zhou	PROPN
admet-2874	795	18	,	,	PUNCT
admet-2874	795	19	h.	h.	PROPN
admet-2874	795	20	li	li	PROPN
admet-2874	795	21	,	,	PUNCT
admet-2874	795	22	j.	j.	PROPN
admet-2874	795	23	wen	wen	PROPN
admet-2874	795	24	,	,	PUNCT
admet-2874	795	25	y.	y.	PROPN
admet-2874	795	26	meng	meng	PROPN
admet-2874	795	27	,	,	PUNCT
admet-2874	795	28	m.	m.	PROPN
admet-2874	795	29	lin	lin	PROPN
admet-2874	795	30	,	,	PUNCT
admet-2874	795	31	y.	y.	PROPN
admet-2874	795	32	zhang	zhang	PROPN
admet-2874	795	33	,	,	PUNCT
admet-2874	795	34	h.	h.	PROPN
admet-2874	795	35	huang	huang	PROPN
admet-2874	795	36	,	,	PUNCT
admet-2874	795	37	l.	l.	PROPN
admet-2874	795	38	wang	wang	PROPN
admet-2874	795	39	,	,	PUNCT
admet-2874	795	40	w.	w.	PROPN
admet-2874	795	41	zheng	zheng	PROPN
admet-2874	795	42	.	.	PUNCT
admet-2874	796	1	reactive	reactive	ADJ
admet-2874	796	2	oxygen	oxygen	NOUN
admet-2874	796	3	species	specie	NOUN
admet-2874	796	4	-	-	PUNCT
admet-2874	796	5	responsive	responsive	ADJ
admet-2874	796	6	polypeptide	polypeptide	ADJ
admet-2874	796	7	drug	drug	NOUN
admet-2874	796	8	delivery	delivery	NOUN
admet-2874	796	9	system	system	NOUN
admet-2874	796	10	targeted	target	VERB
admet-2874	796	11	activated	activate	VERB
admet-2874	796	12	hepatic	hepatic	ADJ
admet-2874	796	13	stellate	stellate	ADJ
admet-2874	796	14	cells	cell	NOUN
admet-2874	796	15	to	to	PART
admet-2874	796	16	ameliorate	ameliorate	VERB
admet-2874	796	17	liver	liver	NOUN
admet-2874	796	18	fibrosis	fibrosis	NOUN
admet-2874	796	19	.	.	PUNCT
admet-2874	797	1	acs	acs	PROPN
admet-2874	797	2	nano	nano	VERB
admet-2874	797	3	16	16	NUM
admet-2874	797	4	(	(	PUNCT
admet-2874	797	5	2022	2022	NUM
admet-2874	797	6	)	)	PUNCT
admet-2874	797	7	20739	20739	NUM
admet-2874	797	8	-	-	SYM
admet-2874	797	9	20757	20757	NUM
admet-2874	797	10	.	.	PUNCT
admet-2874	798	1	https://doi.org/10.1021/acsnano.2c07796	https://doi.org/10.1021/acsnano.2c07796	ADV
admet-2874	798	2	134	134	NUM
admet-2874	798	3	.	.	PUNCT
admet-2874	799	1	m.a	m.a	PROPN
admet-2874	799	2	.	.	PROPN
admet-2874	799	3	morsy	morsy	PROPN
admet-2874	799	4	,	,	PUNCT
admet-2874	799	5	a.b	a.b	PROPN
admet-2874	799	6	.	.	PROPN
admet-2874	799	7	nair	nair	PROPN
admet-2874	799	8	.	.	PUNCT
admet-2874	800	1	prevention	prevention	NOUN
admet-2874	800	2	of	of	ADP
admet-2874	800	3	rat	rat	NOUN
admet-2874	800	4	liver	liver	NOUN
admet-2874	800	5	fibrosis	fibrosis	NOUN
admet-2874	800	6	by	by	ADP
admet-2874	800	7	selective	selective	ADJ
admet-2874	800	8	targeting	targeting	NOUN
admet-2874	800	9	of	of	ADP
admet-2874	800	10	hepatic	hepatic	ADJ
admet-2874	800	11	stellate	stellate	ADJ
admet-2874	800	12	cells	cell	NOUN
admet-2874	800	13	using	use	VERB
admet-2874	800	14	hesperidin	hesperidin	NOUN
admet-2874	800	15	carriers	carrier	NOUN
admet-2874	800	16	.	.	PUNCT
admet-2874	801	1	international	international	ADJ
admet-2874	801	2	journal	journal	PROPN
admet-2874	801	3	of	of	ADP
admet-2874	801	4	pharmaceutics	pharmaceutic	NOUN
admet-2874	801	5	552	552	NUM
admet-2874	801	6	(	(	PUNCT
admet-2874	801	7	2018	2018	NUM
admet-2874	801	8	)	)	PUNCT
admet-2874	801	9	241	241	NUM
admet-2874	801	10	-	-	SYM
admet-2874	801	11	250	250	NUM
admet-2874	801	12	.	.	PUNCT
admet-2874	802	1	https://doi.org/10.1016/j.ijpharm.2018.10.003	https://doi.org/10.1016/j.ijpharm.2018.10.003	NUM
admet-2874	802	2	135	135	NUM
admet-2874	802	3	.	.	PUNCT
admet-2874	802	4	j.	j.	PROPN
admet-2874	802	5	wu	wu	PROPN
admet-2874	802	6	,	,	PUNCT
admet-2874	802	7	c.	c.	PROPN
admet-2874	802	8	qi	qi	PROPN
admet-2874	802	9	,	,	PUNCT
admet-2874	802	10	h.	h.	PROPN
admet-2874	802	11	wang	wang	PROPN
admet-2874	802	12	,	,	PUNCT
admet-2874	802	13	q.	q.	PROPN
admet-2874	802	14	wang	wang	PROPN
admet-2874	802	15	,	,	PUNCT
admet-2874	802	16	j.	j.	PROPN
admet-2874	802	17	sun	sun	PROPN
admet-2874	802	18	,	,	PUNCT
admet-2874	802	19	j.	j.	PROPN
admet-2874	802	20	dong	dong	PROPN
admet-2874	802	21	,	,	PUNCT
admet-2874	802	22	g.	g.	PROPN
admet-2874	802	23	yu	yu	PROPN
admet-2874	802	24	,	,	PUNCT
admet-2874	802	25	z.	z.	PROPN
admet-2874	802	26	gao	gao	PROPN
admet-2874	802	27	,	,	PUNCT
admet-2874	802	28	b.	b.	PROPN
admet-2874	802	29	zhang	zhang	PROPN
admet-2874	802	30	,	,	PUNCT
admet-2874	802	31	g.	g.	PROPN
admet-2874	802	32	tian	tian	PROPN
admet-2874	802	33	.	.	PUNCT
admet-2874	803	1	curcumin	curcumin	NOUN
admet-2874	803	2	and	and	CCONJ
admet-2874	803	3	berberine	berberine	NOUN
admet-2874	803	4	co	co	VERB
admet-2874	803	5	-	-	VERB
admet-2874	803	6	loaded	load	VERB
admet-2874	803	7	liposomes	liposome	NOUN
admet-2874	803	8	for	for	ADP
admet-2874	803	9	anti	anti	ADJ
admet-2874	803	10	-	-	ADJ
admet-2874	803	11	hepatocellular	hepatocellular	ADJ
admet-2874	803	12	carcinoma	carcinoma	NOUN
admet-2874	803	13	therapy	therapy	NOUN
admet-2874	803	14	by	by	ADP
admet-2874	803	15	blocking	block	VERB
admet-2874	803	16	the	the	DET
admet-2874	803	17	cross	cross	NOUN
admet-2874	803	18	-	-	NOUN
admet-2874	803	19	talk	talk	NOUN
admet-2874	803	20	between	between	ADP
admet-2874	803	21	hepatic	hepatic	ADJ
admet-2874	803	22	stellate	stellate	ADJ
admet-2874	803	23	cells	cell	NOUN
admet-2874	803	24	and	and	CCONJ
admet-2874	803	25	tumor	tumor	NOUN
admet-2874	803	26	cells	cell	NOUN
admet-2874	803	27	.	.	PUNCT
admet-2874	804	1	frontiers	frontier	NOUN
admet-2874	804	2	in	in	ADP
admet-2874	804	3	pharmacology	pharmacology	NOUN
admet-2874	804	4	13	13	NUM
admet-2874	804	5	(	(	PUNCT
admet-2874	804	6	2022	2022	NUM
admet-2874	804	7	)	)	PUNCT
admet-2874	804	8	961788	961788	NUM
admet-2874	804	9	.	.	PUNCT
admet-2874	805	1	https://doi.org/10.3389/fphar.2022.961788	https://doi.org/10.3389/fphar.2022.961788	NOUN
admet-2874	805	2	136	136	NUM
admet-2874	805	3	.	.	PUNCT
admet-2874	806	1	r.	r.	PROPN
admet-2874	806	2	omar	omar	PROPN
admet-2874	806	3	,	,	PUNCT
admet-2874	806	4	j.	j.	PROPN
admet-2874	806	5	yang	yang	PROPN
admet-2874	806	6	,	,	PUNCT
admet-2874	806	7	s.	s.	PROPN
admet-2874	806	8	alrushaid	alrushaid	PROPN
admet-2874	806	9	,	,	PUNCT
admet-2874	806	10	f.j	f.j	PROPN
admet-2874	806	11	.	.	PROPN
admet-2874	806	12	burczynski	burczynski	PROPN
admet-2874	806	13	,	,	PUNCT
admet-2874	806	14	g.y	g.y	PROPN
admet-2874	806	15	.	.	PUNCT
admet-2874	806	16	minuk	minuk	PROPN
admet-2874	806	17	,	,	PUNCT
admet-2874	806	18	y.	y.	PROPN
admet-2874	806	19	gong	gong	PROPN
admet-2874	806	20	.	.	PUNCT
admet-2874	807	1	inhibition	inhibition	NOUN
admet-2874	807	2	of	of	ADP
admet-2874	807	3	bmp4	bmp4	NOUN
admet-2874	807	4	and	and	CCONJ
admet-2874	807	5	alpha	alpha	NOUN
admet-2874	807	6	smooth	smooth	ADJ
admet-2874	807	7	muscle	muscle	NOUN
admet-2874	807	8	actin	actin	NOUN
admet-2874	807	9	expression	expression	NOUN
admet-2874	807	10	in	in	ADP
admet-2874	807	11	lx-2	lx-2	NUM
admet-2874	807	12	hepatic	hepatic	ADJ
admet-2874	807	13	stellate	stellate	ADJ
admet-2874	807	14	cells	cell	NOUN
admet-2874	807	15	by	by	ADP
admet-2874	807	16	bmp4	bmp4	NOUN
admet-2874	807	17	-	-	PUNCT
admet-2874	807	18	sirna	sirna	PROPN
admet-2874	807	19	lipid	lipid	PROPN
admet-2874	807	20	based	base	VERB
admet-2874	807	21	nanoparticle	nanoparticle	NOUN
admet-2874	807	22	.	.	PUNCT
admet-2874	808	1	journal	journal	PROPN
admet-2874	808	2	of	of	ADP
admet-2874	808	3	pharmacy	pharmacy	NOUN
admet-2874	808	4	and	and	CCONJ
admet-2874	808	5	pharmaceutical	pharmaceutical	NOUN
admet-2874	808	6	sciences	science	NOUN
admet-2874	808	7	21	21	NUM
admet-2874	808	8	(	(	PUNCT
admet-2874	808	9	2019	2019	NUM
admet-2874	808	10	)	)	PUNCT
admet-2874	808	11	119	119	NUM
admet-2874	808	12	-	-	SYM
admet-2874	808	13	134	134	NUM
admet-2874	808	14	.	.	PUNCT
admet-2874	809	1	https://doi.org/10.18433/jpps29584	https://doi.org/10.18433/jpps29584	PROPN
admet-2874	809	2	137	137	NUM
admet-2874	809	3	.	.	PUNCT
admet-2874	810	1	a.	a.	PROPN
admet-2874	810	2	ullah	ullah	PROPN
admet-2874	810	3	,	,	PUNCT
admet-2874	810	4	k.	k.	PROPN
admet-2874	810	5	wang	wang	PROPN
admet-2874	810	6	,	,	PUNCT
admet-2874	810	7	p.	p.	PROPN
admet-2874	810	8	wu	wu	PROPN
admet-2874	810	9	,	,	PUNCT
admet-2874	810	10	d.	d.	PROPN
admet-2874	810	11	oupicky	oupicky	PROPN
admet-2874	810	12	,	,	PUNCT
admet-2874	810	13	m.	m.	NOUN
admet-2874	810	14	sun	sun	PROPN
admet-2874	810	15	.	.	PUNCT
admet-2874	811	1	cxcr4	cxcr4	NOUN
admet-2874	811	2	-	-	PUNCT
admet-2874	811	3	targeted	target	VERB
admet-2874	811	4	liposomal	liposomal	NOUN
admet-2874	811	5	mediated	mediate	VERB
admet-2874	811	6	co	co	NOUN
admet-2874	812	1	-	-	NOUN
admet-2874	813	1	delivery	delivery	NOUN
admet-2874	813	2	of	of	ADP
admet-2874	813	3	pirfenidone	pirfenidone	NOUN
admet-2874	813	4	and	and	CCONJ
admet-2874	813	5	amd3100	amd3100	VERB
admet-2874	813	6	for	for	ADP
admet-2874	813	7	the	the	DET
admet-2874	813	8	treatment	treatment	NOUN
admet-2874	813	9	of	of	ADP
admet-2874	813	10	tgfβ	tgfβ	ADV
admet-2874	813	11	-	-	PUNCT
admet-2874	813	12	induced	induce	VERB
admet-2874	813	13	hsc	hsc	PROPN
admet-2874	813	14	-	-	PUNCT
admet-2874	813	15	t6	t6	PROPN
admet-2874	813	16	cells	cell	NOUN
admet-2874	813	17	activation	activation	NOUN
admet-2874	813	18	.	.	PUNCT
admet-2874	814	1	international	international	ADJ
admet-2874	814	2	journal	journal	NOUN
admet-2874	814	3	of	of	ADP
admet-2874	814	4	nanomedicine	nanomedicine	NOUN
admet-2874	814	5	14	14	NUM
admet-2874	814	6	(	(	PUNCT
admet-2874	814	7	2019	2019	NUM
admet-2874	814	8	)	)	PUNCT
admet-2874	814	9	2927	2927	NUM
admet-2874	814	10	-	-	SYM
admet-2874	814	11	2944	2944	NUM
admet-2874	814	12	.	.	PUNCT
admet-2874	815	1	https://doi.org/10.2147/ijn.s171280	https://doi.org/10.2147/ijn.s171280	NOUN
admet-2874	815	2	138	138	NUM
admet-2874	815	3	.	.	PUNCT
admet-2874	816	1	g.	g.	PROPN
admet-2874	816	2	valentino	valentino	PROPN
admet-2874	816	3	,	,	PUNCT
admet-2874	816	4	c.	c.	PROPN
admet-2874	816	5	zivko	zivko	PROPN
admet-2874	816	6	,	,	PUNCT
admet-2874	816	7	f.	f.	PROPN
admet-2874	816	8	weber	weber	PROPN
admet-2874	816	9	,	,	PUNCT
admet-2874	816	10	l.	l.	PROPN
admet-2874	816	11	brülisauer	brülisauer	PROPN
admet-2874	816	12	,	,	PUNCT
admet-2874	816	13	p.	p.	NOUN
admet-2874	816	14	luciani	luciani	PROPN
admet-2874	816	15	,	,	PUNCT
admet-2874	816	16	synergy	synergy	NOUN
admet-2874	816	17	of	of	ADP
admet-2874	816	18	phospholipid	phospholipid	NOUN
admet-2874	816	19	-	-	PUNCT
admet-2874	816	20	drug	drug	NOUN
admet-2874	816	21	formulations	formulation	NOUN
admet-2874	816	22	significantly	significantly	ADV
admet-2874	816	23	deactivates	deactivate	VERB
admet-2874	816	24	profibrogenic	profibrogenic	ADJ
admet-2874	816	25	human	human	ADJ
admet-2874	816	26	hepatic	hepatic	ADJ
admet-2874	816	27	stellate	stellate	ADJ
admet-2874	816	28	cells	cell	NOUN
admet-2874	816	29	.	.	PUNCT
admet-2874	817	1	pharmaceutics	pharmaceutic	NOUN
admet-2874	817	2	11(12	11(12	NUM
admet-2874	817	3	)	)	PUNCT
admet-2874	817	4	(	(	PUNCT
admet-2874	817	5	2019	2019	NUM
admet-2874	817	6	)	)	PUNCT
admet-2874	817	7	676	676	NUM
admet-2874	817	8	.	.	PUNCT
admet-2874	818	1	https://doi.org/10.3390/pharmaceutics11120676	https://doi.org/10.3390/pharmaceutics11120676	PROPN
admet-2874	818	2	139	139	NUM
admet-2874	818	3	.	.	PUNCT
admet-2874	819	1	q.q	q.q	PROPN
admet-2874	819	2	.	.	PROPN
admet-2874	819	3	fan	fan	PROPN
admet-2874	819	4	,	,	PUNCT
admet-2874	819	5	c.l	c.l	PROPN
admet-2874	819	6	.	.	PROPN
admet-2874	819	7	zhang	zhang	PROPN
admet-2874	819	8	,	,	PUNCT
admet-2874	819	9	j.b	j.b	PROPN
admet-2874	819	10	.	.	PROPN
admet-2874	819	11	qiao	qiao	PROPN
admet-2874	819	12	,	,	PUNCT
admet-2874	819	13	p.f	p.f	PROPN
admet-2874	819	14	.	.	PROPN
admet-2874	819	15	cui	cui	PROPN
admet-2874	819	16	,	,	PUNCT
admet-2874	819	17	l.	l.	PROPN
admet-2874	819	18	xing	xing	PROPN
admet-2874	819	19	,	,	PUNCT
admet-2874	819	20	y.k	y.k	PROPN
admet-2874	819	21	.	.	PROPN
admet-2874	820	1	oh	oh	INTJ
admet-2874	820	2	,	,	PUNCT
admet-2874	820	3	h.l	h.l	PROPN
admet-2874	820	4	.	.	PROPN
admet-2874	820	5	jiang	jiang	PROPN
admet-2874	820	6	.	.	PUNCT
admet-2874	821	1	extracellular	extracellular	ADJ
admet-2874	821	2	matrixpenetrating	matrixpenetrate	VERB
admet-2874	821	3	nanodrill	nanodrill	NOUN
admet-2874	821	4	micelles	micelle	NOUN
admet-2874	821	5	for	for	ADP
admet-2874	821	6	liver	liver	NOUN
admet-2874	821	7	fibrosis	fibrosis	NOUN
admet-2874	821	8	therapy	therapy	NOUN
admet-2874	821	9	.	.	PUNCT
admet-2874	822	1	biomaterials	biomaterial	NOUN
admet-2874	822	2	230	230	NUM
admet-2874	822	3	(	(	PUNCT
admet-2874	822	4	2020	2020	NUM
admet-2874	822	5	)	)	PUNCT
admet-2874	822	6	119616	119616	NUM
admet-2874	822	7	.	.	PUNCT
admet-2874	823	1	https://doi.org/10.1016/j.biomaterials.2019.119616	https://doi.org/10.1016/j.biomaterials.2019.119616	PROPN
admet-2874	823	2	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	VERB
admet-2874	823	3	https://doi.org/10.1039/d2ra07561j	https://doi.org/10.1039/d2ra07561j	PROPN
admet-2874	823	4	https://doi.org/10.1111/jcmm.16209	https://doi.org/10.1111/jcmm.16209	NOUN
admet-2874	823	5	https://doi.org/10.1021/acsnano.2c07796	https://doi.org/10.1021/acsnano.2c07796	SCONJ
admet-2874	823	6	https://doi.org/10.3389/fphar.2022.961788	https://doi.org/10.3389/fphar.2022.961788	X
admet-2874	823	7	https://doi.org/10.18433/jpps29584	https://doi.org/10.18433/jpps29584	PROPN
admet-2874	823	8	https://doi.org/10.2147/ijn.s171280	https://doi.org/10.2147/ijn.s171280	PROPN
admet-2874	823	9	https://doi.org/10.3390/pharmaceutics11120676	https://doi.org/10.3390/pharmaceutics11120676	PROPN
admet-2874	823	10	a.	a.	PROPN
admet-2874	823	11	singh	singh	PROPN
admet-2874	823	12	et	et	PROPN
admet-2874	823	13	al	al	PROPN
admet-2874	823	14	.	.	PROPN
admet-2874	823	15	admet	admet	PROPN
admet-2874	823	16	&	&	CCONJ
admet-2874	823	17	dmpk	dmpk	PROPN
admet-2874	823	18	13(4	13(4	NUM
admet-2874	823	19	)	)	PUNCT
admet-2874	823	20	(	(	PUNCT
admet-2874	823	21	2025	2025	NUM
admet-2874	823	22	)	)	PUNCT
admet-2874	823	23	2874	2874	NUM
admet-2874	823	24	26	26	NUM
admet-2874	823	25	140	140	NUM
admet-2874	823	26	.	.	PUNCT
admet-2874	824	1	m.	m.	PROPN
admet-2874	824	2	wang	wang	PROPN
admet-2874	824	3	,	,	PUNCT
admet-2874	824	4	m.	m.	PROPN
admet-2874	824	5	zhang	zhang	PROPN
admet-2874	824	6	,	,	PUNCT
admet-2874	824	7	l.	l.	PROPN
admet-2874	824	8	fu	fu	PROPN
admet-2874	824	9	,	,	PUNCT
admet-2874	824	10	j.	j.	PROPN
admet-2874	824	11	lin	lin	PROPN
admet-2874	824	12	,	,	PUNCT
admet-2874	824	13	x.	x.	PROPN
admet-2874	824	14	zhou	zhou	PROPN
admet-2874	824	15	,	,	PUNCT
admet-2874	824	16	p.	p.	NOUN
admet-2874	824	17	zhou	zhou	PROPN
admet-2874	824	18	,	,	PUNCT
admet-2874	824	19	p.	p.	PROPN
admet-2874	824	20	huang	huang	PROPN
admet-2874	824	21	,	,	PUNCT
admet-2874	824	22	h.	h.	PROPN
admet-2874	824	23	hu	hu	PROPN
admet-2874	824	24	,	,	PUNCT
admet-2874	824	25	y.	y.	PROPN
admet-2874	824	26	han	han	PROPN
admet-2874	824	27	.	.	PUNCT
admet-2874	825	1	liver	liver	NOUN
admet-2874	825	2	-	-	PUNCT
admet-2874	825	3	targeted	target	VERB
admet-2874	825	4	delivery	delivery	NOUN
admet-2874	825	5	of	of	ADP
admet-2874	825	6	tsg-6	tsg-6	PUNCT
admet-2874	825	7	by	by	ADP
admet-2874	825	8	calcium	calcium	NOUN
admet-2874	825	9	phosphate	phosphate	NOUN
admet-2874	825	10	nanoparticles	nanoparticle	NOUN
admet-2874	825	11	for	for	ADP
admet-2874	825	12	the	the	DET
admet-2874	825	13	management	management	NOUN
admet-2874	825	14	of	of	ADP
admet-2874	825	15	liver	liver	NOUN
admet-2874	825	16	fibrosis	fibrosis	NOUN
admet-2874	825	17	.	.	PUNCT
admet-2874	826	1	theranostics	theranostic	NOUN
admet-2874	826	2	10	10	NUM
admet-2874	826	3	(	(	PUNCT
admet-2874	826	4	2020	2020	NUM
admet-2874	826	5	)	)	PUNCT
admet-2874	826	6	36	36	NUM
admet-2874	826	7	-	-	SYM
admet-2874	826	8	49	49	NUM
admet-2874	826	9	.	.	PUNCT
admet-2874	827	1	https://doi.org/10.7150/thno.37301	https://doi.org/10.7150/thno.37301	X
admet-2874	827	2	141	141	NUM
admet-2874	827	3	.	.	PUNCT
admet-2874	828	1	j.	j.	PROPN
admet-2874	828	2	wang	wang	PROPN
admet-2874	828	3	,	,	PUNCT
admet-2874	828	4	y.	y.	PROPN
admet-2874	828	5	ding	ding	PROPN
admet-2874	828	6	,	,	PUNCT
admet-2874	828	7	w.	w.	PROPN
admet-2874	828	8	zhou	zhou	PROPN
admet-2874	828	9	.	.	PUNCT
admet-2874	829	1	albumin	albumin	ADJ
admet-2874	829	2	self	self	NOUN
admet-2874	829	3	-	-	PUNCT
admet-2874	829	4	modified	modify	VERB
admet-2874	829	5	liposomes	liposome	NOUN
admet-2874	829	6	for	for	ADP
admet-2874	829	7	hepatic	hepatic	ADJ
admet-2874	829	8	fibrosis	fibrosis	NOUN
admet-2874	829	9	therapy	therapy	NOUN
admet-2874	829	10	via	via	ADP
admet-2874	829	11	sparc	sparc	NOUN
admet-2874	829	12	-	-	PUNCT
admet-2874	829	13	dependent	dependent	ADJ
admet-2874	829	14	pathways	pathway	NOUN
admet-2874	829	15	.	.	PUNCT
admet-2874	830	1	international	international	ADJ
admet-2874	830	2	journal	journal	PROPN
admet-2874	830	3	of	of	ADP
admet-2874	830	4	pharmaceutics	pharmaceutic	NOUN
admet-2874	830	5	574	574	NUM
admet-2874	830	6	(	(	PUNCT
admet-2874	830	7	2020	2020	NUM
admet-2874	830	8	)	)	PUNCT
admet-2874	830	9	118940	118940	NUM
admet-2874	830	10	.	.	PUNCT
admet-2874	831	1	https://doi.org/10.1016/j.ijpharm.2019.118940	https://doi.org/10.1016/j.ijpharm.2019.118940	NOUN
admet-2874	831	2	142	142	NUM
admet-2874	831	3	.	.	PUNCT
admet-2874	832	1	c.	c.	PROPN
admet-2874	832	2	qi	qi	PROPN
admet-2874	832	3	,	,	PUNCT
admet-2874	832	4	d.	d.	PROPN
admet-2874	832	5	wang	wang	PROPN
admet-2874	832	6	,	,	PUNCT
admet-2874	832	7	x.	x.	PROPN
admet-2874	832	8	gong	gong	PROPN
admet-2874	832	9	,	,	PUNCT
admet-2874	832	10	q.	q.	PROPN
admet-2874	832	11	zhou	zhou	PROPN
admet-2874	832	12	,	,	PUNCT
admet-2874	832	13	x.	x.	PROPN
admet-2874	832	14	yue	yue	PROPN
admet-2874	832	15	,	,	PUNCT
admet-2874	832	16	c.	c.	PROPN
admet-2874	832	17	li	li	PROPN
admet-2874	832	18	,	,	PUNCT
admet-2874	832	19	z.	z.	PROPN
admet-2874	832	20	li	li	PROPN
admet-2874	832	21	,	,	PUNCT
admet-2874	832	22	g.	g.	PROPN
admet-2874	832	23	tian	tian	PROPN
admet-2874	832	24	,	,	PUNCT
admet-2874	832	25	b.	b.	PROPN
admet-2874	832	26	zhang	zhang	PROPN
admet-2874	832	27	,	,	PUNCT
admet-2874	832	28	q.	q.	PROPN
admet-2874	832	29	wang	wang	PROPN
admet-2874	832	30	,	,	PUNCT
admet-2874	832	31	x.	x.	PROPN
admet-2874	832	32	wei	wei	PROPN
admet-2874	832	33	,	,	PUNCT
admet-2874	832	34	j.	j.	PROPN
admet-2874	832	35	wu	wu	PROPN
admet-2874	832	36	.	.	PUNCT
admet-2874	833	1	co	co	NOUN
admet-2874	834	1	-	-	NOUN
admet-2874	834	2	delivery	delivery	NOUN
admet-2874	834	3	of	of	ADP
admet-2874	834	4	curcumin	curcumin	NOUN
admet-2874	834	5	and	and	CCONJ
admet-2874	834	6	capsaicin	capsaicin	NOUN
admet-2874	834	7	by	by	ADP
admet-2874	834	8	dual	dual	ADV
admet-2874	834	9	-	-	PUNCT
admet-2874	834	10	targeting	target	VERB
admet-2874	834	11	liposomes	liposome	NOUN
admet-2874	834	12	for	for	ADP
admet-2874	834	13	inhibition	inhibition	NOUN
admet-2874	834	14	of	of	ADP
admet-2874	834	15	ahscinduced	ahscinduced	ADJ
admet-2874	834	16	drug	drug	NOUN
admet-2874	834	17	resistance	resistance	NOUN
admet-2874	834	18	and	and	CCONJ
admet-2874	834	19	metastasis	metastasis	NOUN
admet-2874	834	20	.	.	PUNCT
admet-2874	835	1	acs	acs	PROPN
admet-2874	835	2	applied	apply	VERB
admet-2874	835	3	materials	material	NOUN
admet-2874	835	4	interfaces	interface	NOUN
admet-2874	835	5	13	13	NUM
admet-2874	835	6	(	(	PUNCT
admet-2874	835	7	2021	2021	NUM
admet-2874	835	8	)	)	PUNCT
admet-2874	835	9	1601916035	1601916035	NUM
admet-2874	835	10	.	.	PUNCT
admet-2874	836	1	https://doi.org/10.1021/acsami.0c23137	https://doi.org/10.1021/acsami.0c23137	NOUN
admet-2874	836	2	143	143	NUM
admet-2874	836	3	.	.	PUNCT
admet-2874	837	1	s.	s.	PROPN
admet-2874	837	2	luo	luo	PROPN
admet-2874	837	3	,	,	PUNCT
admet-2874	837	4	y.	y.	PROPN
admet-2874	837	5	yang	yang	PROPN
admet-2874	837	6	,	,	PUNCT
admet-2874	837	7	t.	t.	PROPN
admet-2874	837	8	zhao	zhao	PROPN
admet-2874	837	9	,	,	PUNCT
admet-2874	837	10	r.	r.	PROPN
admet-2874	837	11	zhang	zhang	PROPN
admet-2874	837	12	,	,	PUNCT
admet-2874	837	13	c.	c.	PROPN
admet-2874	837	14	fang	fang	PROPN
admet-2874	837	15	,	,	PUNCT
admet-2874	837	16	y.	y.	PROPN
admet-2874	837	17	li	li	PROPN
admet-2874	837	18	,	,	PUNCT
admet-2874	837	19	z.	z.	PROPN
admet-2874	837	20	zhang	zhang	PROPN
admet-2874	837	21	,	,	PUNCT
admet-2874	837	22	t.	t.	PROPN
admet-2874	837	23	gong	gong	PROPN
admet-2874	837	24	.	.	PUNCT
admet-2874	838	1	albumin	albumin	NOUN
admet-2874	838	2	-	-	PUNCT
admet-2874	838	3	based	base	VERB
admet-2874	838	4	silibinin	silibinin	NOUN
admet-2874	838	5	nanocrystals	nanocrystal	NOUN
admet-2874	838	6	targeting	target	VERB
admet-2874	838	7	activated	activate	VERB
admet-2874	838	8	hepatic	hepatic	ADJ
admet-2874	838	9	stellate	stellate	ADJ
admet-2874	838	10	cells	cell	NOUN
admet-2874	838	11	for	for	ADP
admet-2874	838	12	liver	liver	NOUN
admet-2874	838	13	fibrosis	fibrosis	NOUN
admet-2874	838	14	therapy	therapy	NOUN
admet-2874	838	15	.	.	PUNCT
admet-2874	839	1	acs	acs	PROPN
admet-2874	839	2	applied	apply	VERB
admet-2874	839	3	materials	material	NOUN
admet-2874	839	4	interfaces	interface	NOUN
admet-2874	839	5	15	15	NUM
admet-2874	839	6	(	(	PUNCT
admet-2874	839	7	2023	2023	NUM
admet-2874	839	8	)	)	PUNCT
admet-2874	839	9	7747	7747	NUM
admet-2874	839	10	-	-	SYM
admet-2874	839	11	7758	7758	NUM
admet-2874	839	12	.	.	PUNCT
admet-2874	840	1	https://doi.org/10.1021/acsami.2c19269	https://doi.org/10.1021/acsami.2c19269	NOUN
admet-2874	840	2	144	144	NUM
admet-2874	840	3	.	.	PUNCT
admet-2874	841	1	d.g	d.g	PROPN
admet-2874	841	2	.	.	PUNCT
admet-2874	842	1	you	you	PRON
admet-2874	842	2	,	,	PUNCT
admet-2874	842	3	b.h	b.h	PROPN
admet-2874	842	4	.	.	PUNCT
admet-2874	843	1	oh	oh	INTJ
admet-2874	843	2	,	,	PUNCT
admet-2874	843	3	v.q	v.q	PROPN
admet-2874	843	4	.	.	PROPN
admet-2874	843	5	nguyen	nguyen	PROPN
admet-2874	843	6	,	,	PUNCT
admet-2874	843	7	g.t	g.t	PROPN
admet-2874	843	8	.	.	PROPN
admet-2874	843	9	lim	lim	PROPN
admet-2874	843	10	,	,	PUNCT
admet-2874	843	11	w.	w.	PROPN
admet-2874	843	12	um	um	INTJ
admet-2874	843	13	,	,	PUNCT
admet-2874	843	14	j.m	j.m	PROPN
admet-2874	843	15	.	.	PROPN
admet-2874	843	16	jung	jung	PROPN
admet-2874	843	17	,	,	PUNCT
admet-2874	843	18	j.	j.	PROPN
admet-2874	843	19	jeon	jeon	PROPN
admet-2874	843	20	,	,	PUNCT
admet-2874	843	21	j.s	j.s	PROPN
admet-2874	843	22	.	.	PROPN
admet-2874	843	23	choi	choi	PROPN
admet-2874	843	24	,	,	PUNCT
admet-2874	843	25	y.c	y.c	PROPN
admet-2874	843	26	.	.	PROPN
admet-2874	843	27	choi	choi	PROPN
admet-2874	843	28	,	,	PUNCT
admet-2874	843	29	y.j	y.j	PROPN
admet-2874	843	30	.	.	PROPN
admet-2874	843	31	jung	jung	PROPN
admet-2874	843	32	,	,	PUNCT
admet-2874	843	33	j.	j.	PROPN
admet-2874	843	34	lee	lee	PROPN
admet-2874	843	35	,	,	PUNCT
admet-2874	843	36	d.g	d.g	PROPN
admet-2874	843	37	.	.	PROPN
admet-2874	843	38	jo	jo	PROPN
admet-2874	843	39	,	,	PUNCT
admet-2874	843	40	y.w	y.w	PROPN
admet-2874	843	41	.	.	PROPN
admet-2874	843	42	cho	cho	PROPN
admet-2874	843	43	,	,	PUNCT
admet-2874	843	44	j.h	j.h	PROPN
admet-2874	843	45	.	.	PROPN
admet-2874	843	46	park	park	PROPN
admet-2874	843	47	.	.	PUNCT
admet-2874	844	1	vitamin	vitamin	VERB
admet-2874	844	2	a	a	DET
admet-2874	844	3	-	-	PUNCT
admet-2874	844	4	coupled	couple	VERB
admet-2874	844	5	stem	stem	NOUN
admet-2874	844	6	cell	cell	NOUN
admet-2874	844	7	-	-	PUNCT
admet-2874	844	8	derived	derive	VERB
admet-2874	844	9	extracellular	extracellular	ADJ
admet-2874	844	10	vesicles	vesicle	NOUN
admet-2874	844	11	regulate	regulate	VERB
admet-2874	844	12	the	the	DET
admet-2874	844	13	fibrotic	fibrotic	ADJ
admet-2874	844	14	cascade	cascade	NOUN
admet-2874	844	15	by	by	ADP
admet-2874	844	16	targeting	target	VERB
admet-2874	844	17	activated	activate	VERB
admet-2874	844	18	hepatic	hepatic	ADJ
admet-2874	844	19	stellate	stellate	ADJ
admet-2874	844	20	cells	cell	NOUN
admet-2874	844	21	in	in	ADP
admet-2874	844	22	vivo	vivo	NOUN
admet-2874	844	23	.	.	PUNCT
admet-2874	845	1	journal	journal	PROPN
admet-2874	845	2	of	of	ADP
admet-2874	845	3	controlled	control	VERB
admet-2874	845	4	release	release	NOUN
admet-2874	845	5	336	336	NUM
admet-2874	845	6	(	(	PUNCT
admet-2874	845	7	2021	2021	NUM
admet-2874	845	8	)	)	PUNCT
admet-2874	845	9	285	285	NUM
admet-2874	845	10	-	-	SYM
admet-2874	845	11	295	295	NUM
admet-2874	845	12	.	.	PUNCT
admet-2874	846	1	https://doi.org/10.1016/j.jconrel.2021.06.031	https://doi.org/10.1016/j.jconrel.2021.06.031	NOUN
admet-2874	846	2	145	145	NUM
admet-2874	846	3	.	.	PUNCT
admet-2874	847	1	y.	y.	PROPN
admet-2874	847	2	tan	tan	PROPN
admet-2874	847	3	,	,	PUNCT
admet-2874	847	4	z.	z.	PROPN
admet-2874	847	5	wang	wang	PROPN
admet-2874	847	6	,	,	PUNCT
admet-2874	847	7	r.	r.	PROPN
admet-2874	847	8	guo	guo	PROPN
admet-2874	847	9	,	,	PUNCT
admet-2874	847	10	x.	x.	NOUN
admet-2874	847	11	zhou	zhou	PROPN
admet-2874	847	12	,	,	PUNCT
admet-2874	847	13	w.	w.	PROPN
admet-2874	847	14	zhang	zhang	PROPN
admet-2874	847	15	,	,	PUNCT
admet-2874	847	16	m.	m.	PROPN
admet-2874	847	17	wu	wu	PROPN
admet-2874	847	18	,	,	PUNCT
admet-2874	847	19	c.	c.	PROPN
admet-2874	847	20	guo	guo	PROPN
admet-2874	847	21	,	,	PUNCT
admet-2874	847	22	h.	h.	PROPN
admet-2874	847	23	gao	gao	PROPN
admet-2874	847	24	,	,	PUNCT
admet-2874	847	25	x.	x.	PROPN
admet-2874	847	26	sun	sun	PROPN
admet-2874	847	27	,	,	PUNCT
admet-2874	847	28	z.	z.	PROPN
admet-2874	847	29	zhang	zhang	PROPN
admet-2874	847	30	,	,	PUNCT
admet-2874	847	31	t.	t.	PROPN
admet-2874	847	32	gong	gong	PROPN
admet-2874	847	33	.	.	PUNCT
admet-2874	848	1	dual	dual	ADV
admet-2874	848	2	-	-	PUNCT
admet-2874	848	3	targeting	target	VERB
admet-2874	848	4	macrophages	macrophage	NOUN
admet-2874	848	5	and	and	CCONJ
admet-2874	848	6	hepatic	hepatic	ADJ
admet-2874	848	7	stellate	stellate	ADJ
admet-2874	848	8	cells	cell	NOUN
admet-2874	848	9	by	by	ADP
admet-2874	848	10	modified	modify	VERB
admet-2874	848	11	albumin	albumin	ADJ
admet-2874	848	12	nanoparticles	nanoparticle	NOUN
admet-2874	848	13	for	for	ADP
admet-2874	848	14	liver	liver	NOUN
admet-2874	848	15	cirrhosis	cirrhosis	NOUN
admet-2874	848	16	treatment	treatment	NOUN
admet-2874	848	17	.	.	PUNCT
admet-2874	849	1	acs	acs	PROPN
admet-2874	849	2	applied	apply	VERB
admet-2874	849	3	materials	material	NOUN
admet-2874	849	4	interfaces	interface	NOUN
admet-2874	849	5	16	16	NUM
admet-2874	849	6	(	(	PUNCT
admet-2874	849	7	2024	2024	NUM
admet-2874	849	8	)	)	PUNCT
admet-2874	849	9	11239	11239	NUM
admet-2874	849	10	-	-	SYM
admet-2874	849	11	11250	11250	NUM
admet-2874	849	12	.	.	PUNCT
admet-2874	850	1	https://doi.org/10.1021/acsami.3c17670	https://doi.org/10.1021/acsami.3c17670	NOUN
admet-2874	850	2	146	146	NUM
admet-2874	850	3	.	.	PUNCT
admet-2874	851	1	l.	l.	PROPN
admet-2874	851	2	sun	sun	PROPN
admet-2874	851	3	,	,	PUNCT
admet-2874	851	4	x.	x.	PROPN
admet-2874	851	5	luo	luo	PROPN
admet-2874	851	6	,	,	PUNCT
admet-2874	851	7	c.	c.	PROPN
admet-2874	851	8	zhou	zhou	PROPN
admet-2874	851	9	,	,	PUNCT
admet-2874	851	10	z.	z.	PROPN
admet-2874	851	11	zhou	zhou	PROPN
admet-2874	851	12	,	,	PUNCT
admet-2874	851	13	m.	m.	NOUN
admet-2874	851	14	sun	sun	PROPN
admet-2874	851	15	.	.	PUNCT
admet-2874	851	16	natural	natural	ADJ
admet-2874	851	17	polysaccharide	polysaccharide	NOUN
admet-2874	851	18	-	-	PUNCT
admet-2874	851	19	based	base	VERB
admet-2874	851	20	smart	smart	ADJ
admet-2874	851	21	cxcr4	cxcr4	NOUN
admet-2874	851	22	-	-	PUNCT
admet-2874	851	23	targeted	target	VERB
admet-2874	851	24	nano	nano	NOUN
admet-2874	851	25	-	-	PUNCT
admet-2874	851	26	system	system	NOUN
admet-2874	851	27	for	for	ADP
admet-2874	851	28	magnified	magnify	VERB
admet-2874	851	29	liver	liver	NOUN
admet-2874	851	30	fibrosis	fibrosis	NOUN
admet-2874	851	31	therapy	therapy	NOUN
admet-2874	851	32	.	.	PUNCT
admet-2874	852	1	chinese	chinese	ADJ
admet-2874	852	2	chemical	chemical	PROPN
admet-2874	852	3	letters	letter	NOUN
admet-2874	852	4	35	35	NUM
admet-2874	852	5	(	(	PUNCT
admet-2874	852	6	2024	2024	NUM
admet-2874	852	7	)	)	PUNCT
admet-2874	852	8	108803	108803	NUM
admet-2874	852	9	.	.	PUNCT
admet-2874	853	1	https://doi.org/10.1016/j.cclet.2023.108803	https://doi.org/10.1016/j.cclet.2023.108803	NOUN
admet-2874	853	2	147	147	NUM
admet-2874	853	3	.	.	PUNCT
admet-2874	854	1	z.c	z.c	PROPN
admet-2874	854	2	.	.	PROPN
admet-2874	854	3	wu	wu	PROPN
admet-2874	854	4	,	,	PUNCT
admet-2874	854	5	x.y	x.y	PROPN
admet-2874	854	6	.	.	PROPN
admet-2874	854	7	liu	liu	PROPN
admet-2874	854	8	,	,	PUNCT
admet-2874	854	9	j.y	j.y	PROPN
admet-2874	854	10	.	.	PROPN
admet-2874	854	11	liu	liu	PROPN
admet-2874	854	12	,	,	PUNCT
admet-2874	854	13	j.s	j.s	PROPN
admet-2874	854	14	.	.	PROPN
admet-2874	854	15	piao	piao	PROPN
admet-2874	854	16	,	,	PUNCT
admet-2874	854	17	m.g	m.g	PROPN
admet-2874	854	18	.	.	PROPN
admet-2874	854	19	piao	piao	PROPN
admet-2874	854	20	.	.	PUNCT
admet-2874	855	1	preparation	preparation	NOUN
admet-2874	855	2	of	of	ADP
admet-2874	855	3	betulinic	betulinic	ADJ
admet-2874	855	4	acid	acid	NOUN
admet-2874	855	5	galactosylated	galactosylate	VERB
admet-2874	855	6	chitosan	chitosan	NOUN
admet-2874	855	7	nanoparticles	nanoparticle	NOUN
admet-2874	855	8	and	and	CCONJ
admet-2874	855	9	their	their	PRON
admet-2874	855	10	effect	effect	NOUN
admet-2874	855	11	on	on	ADP
admet-2874	855	12	liver	liver	NOUN
admet-2874	855	13	fibrosis	fibrosis	NOUN
admet-2874	855	14	.	.	PUNCT
admet-2874	856	1	international	international	ADJ
admet-2874	856	2	journal	journal	PROPN
admet-2874	856	3	of	of	ADP
admet-2874	856	4	nanomedicine	nanomedicine	NOUN
admet-2874	856	5	17	17	NUM
admet-2874	856	6	(	(	PUNCT
admet-2874	856	7	2022	2022	NUM
admet-2874	856	8	)	)	PUNCT
admet-2874	856	9	4195	4195	NUM
admet-2874	856	10	-	-	SYM
admet-2874	856	11	4210	4210	NUM
admet-2874	856	12	.	.	PUNCT
admet-2874	857	1	https://doi.org/10.2147/ijn.s373430	https://doi.org/10.2147/ijn.s373430	PROPN
admet-2874	857	2	148	148	NUM
admet-2874	857	3	.	.	PUNCT
admet-2874	857	4	x.	x.	PROPN
admet-2874	857	5	su	su	PROPN
admet-2874	857	6	,	,	PUNCT
admet-2874	857	7	h.	h.	PROPN
admet-2874	857	8	zhong	zhong	PROPN
admet-2874	857	9	,	,	PUNCT
admet-2874	857	10	y.	y.	PROPN
admet-2874	857	11	zeng	zeng	PROPN
admet-2874	857	12	,	,	PUNCT
admet-2874	857	13	y.	y.	PROPN
admet-2874	857	14	zhang	zhang	PROPN
admet-2874	857	15	,	,	PUNCT
admet-2874	857	16	b.	b.	PROPN
admet-2874	857	17	zhang	zhang	PROPN
admet-2874	857	18	,	,	PUNCT
admet-2874	857	19	w.	w.	PROPN
admet-2874	857	20	guo	guo	PROPN
admet-2874	857	21	,	,	PUNCT
admet-2874	857	22	q.	q.	PROPN
admet-2874	857	23	huang	huang	PROPN
admet-2874	857	24	,	,	PUNCT
admet-2874	857	25	y.	y.	PROPN
admet-2874	857	26	ye	ye	PROPN
admet-2874	857	27	.	.	PUNCT
admet-2874	858	1	dual	dual	ADV
admet-2874	858	2	-	-	PUNCT
admet-2874	858	3	ligandfunctionalized	ligandfunctionalize	VERB
admet-2874	858	4	nanostructured	nanostructure	VERB
admet-2874	858	5	lipid	lipid	NOUN
admet-2874	858	6	carriers	carrier	NOUN
admet-2874	858	7	as	as	ADP
admet-2874	858	8	a	a	DET
admet-2874	858	9	novel	novel	ADJ
admet-2874	858	10	dehydrocavidine	dehydrocavidine	ADJ
admet-2874	858	11	delivery	delivery	NOUN
admet-2874	858	12	system	system	NOUN
admet-2874	858	13	for	for	ADP
admet-2874	858	14	liver	liver	NOUN
admet-2874	858	15	fibrosis	fibrosis	NOUN
admet-2874	858	16	therapy	therapy	NOUN
admet-2874	858	17	.	.	PUNCT
admet-2874	859	1	colloids	colloid	NOUN
admet-2874	859	2	and	and	CCONJ
admet-2874	859	3	surfaces	surface	NOUN
admet-2874	859	4	b	b	X
admet-2874	859	5	246	246	NUM
admet-2874	859	6	(	(	PUNCT
admet-2874	859	7	2025	2025	NUM
admet-2874	859	8	)	)	PUNCT
admet-2874	859	9	114376	114376	NUM
admet-2874	859	10	.	.	PUNCT
admet-2874	860	1	https://doi.org/10.1016/j.colsurfb.2024.114376	https://doi.org/10.1016/j.colsurfb.2024.114376	VERB
admet-2874	860	2	149	149	NUM
admet-2874	860	3	.	.	PUNCT
admet-2874	861	1	x.	x.	PROPN
admet-2874	861	2	niu	niu	PROPN
admet-2874	861	3	,	,	PUNCT
admet-2874	861	4	g.	g.	PROPN
admet-2874	861	5	chang	chang	PROPN
admet-2874	861	6	,	,	PUNCT
admet-2874	861	7	n.	n.	PROPN
admet-2874	861	8	xu	xu	PROPN
admet-2874	861	9	,	,	PUNCT
admet-2874	861	10	r.	r.	PROPN
admet-2874	861	11	li	li	PROPN
admet-2874	861	12	,	,	PUNCT
admet-2874	861	13	b.	b.	PROPN
admet-2874	861	14	niu	niu	PROPN
admet-2874	861	15	,	,	PUNCT
admet-2874	861	16	r.	r.	PROPN
admet-2874	861	17	mao	mao	PROPN
admet-2874	861	18	,	,	PUNCT
admet-2874	861	19	s.	s.	PROPN
admet-2874	861	20	wang	wang	PROPN
admet-2874	861	21	,	,	PUNCT
admet-2874	861	22	g.	g.	PROPN
admet-2874	861	23	li	li	PROPN
admet-2874	861	24	,	,	PUNCT
admet-2874	861	25	j.	j.	PROPN
admet-2874	861	26	jiang	jiang	PROPN
admet-2874	861	27	,	,	PUNCT
admet-2874	861	28	l.	l.	PROPN
admet-2874	861	29	wang	wang	PROPN
admet-2874	861	30	.	.	PUNCT
admet-2874	862	1	vitamin	vitamin	PROPN
admet-2874	862	2	aintegrated	aintegrate	VERB
admet-2874	862	3	cinnamaldehyde	cinnamaldehyde	NOUN
admet-2874	862	4	nanoemulsion	nanoemulsion	NOUN
admet-2874	862	5	:	:	PUNCT
admet-2874	862	6	a	a	DET
admet-2874	862	7	nanotherapeutic	nanotherapeutic	ADJ
admet-2874	862	8	approach	approach	NOUN
admet-2874	862	9	to	to	PART
admet-2874	862	10	counteract	counteract	VERB
admet-2874	862	11	liver	liver	NOUN
admet-2874	862	12	fibrosis	fibrosis	NOUN
admet-2874	862	13	via	via	ADP
admet-2874	862	14	gut	gut	NOUN
admet-2874	862	15	-	-	PUNCT
admet-2874	862	16	liver	liver	NOUN
admet-2874	862	17	axis	axis	NOUN
admet-2874	862	18	modulation	modulation	NOUN
admet-2874	862	19	.	.	PUNCT
admet-2874	863	1	acs	acs	PROPN
admet-2874	863	2	nano	nano	PROPN
admet-2874	863	3	19(10	19(10	NUM
admet-2874	863	4	)	)	PUNCT
admet-2874	863	5	(	(	PUNCT
admet-2874	863	6	2025	2025	NUM
admet-2874	863	7	)	)	PUNCT
admet-2874	863	8	10433	10433	NUM
admet-2874	863	9	-	-	SYM
admet-2874	863	10	10451	10451	NUM
admet-2874	863	11	.	.	PUNCT
admet-2874	864	1	https://doi.org/10.1021/acsnano.5c00136	https://doi.org/10.1021/acsnano.5c00136	ADJ
admet-2874	864	2	150	150	NUM
admet-2874	864	3	.	.	PUNCT
admet-2874	865	1	p.	p.	NOUN
admet-2874	865	2	hu	hu	PROPN
admet-2874	865	3	,	,	PUNCT
admet-2874	865	4	l.	l.	PROPN
admet-2874	865	5	su	su	PROPN
admet-2874	865	6	,	,	PUNCT
admet-2874	865	7	y.	y.	PROPN
admet-2874	865	8	wang	wang	PROPN
admet-2874	865	9	,	,	PUNCT
admet-2874	865	10	y.	y.	PROPN
admet-2874	865	11	chen	chen	PROPN
admet-2874	865	12	,	,	PUNCT
admet-2874	865	13	x.	x.	PROPN
admet-2874	865	14	tian	tian	PROPN
admet-2874	865	15	,	,	PUNCT
admet-2874	865	16	y.	y.	PROPN
admet-2874	865	17	qian	qian	PROPN
admet-2874	865	18	.	.	PUNCT
admet-2874	866	1	targeting	target	VERB
admet-2874	866	2	liver	liver	NOUN
admet-2874	866	3	fibrosis	fibrosis	NOUN
admet-2874	866	4	with	with	ADP
admet-2874	866	5	nanoparticle	nanoparticle	NOUN
admet-2874	866	6	technology	technology	NOUN
admet-2874	866	7	:	:	PUNCT
admet-2874	866	8	the	the	DET
admet-2874	866	9	dual	dual	ADJ
admet-2874	866	10	-	-	PUNCT
admet-2874	866	11	drug	drug	NOUN
admet-2874	866	12	strategy	strategy	NOUN
admet-2874	866	13	for	for	ADP
admet-2874	866	14	hepatic	hepatic	ADJ
admet-2874	866	15	stellate	stellate	ADJ
admet-2874	866	16	cell	cell	NOUN
admet-2874	866	17	activation	activation	NOUN
admet-2874	866	18	inhibition	inhibition	NOUN
admet-2874	866	19	.	.	PUNCT
admet-2874	867	1	acs	acs	PROPN
admet-2874	867	2	applied	apply	VERB
admet-2874	867	3	materials	material	NOUN
admet-2874	867	4	and	and	CCONJ
admet-2874	867	5	interfaces	interface	NOUN
admet-2874	867	6	17(17	17(17	NUM
admet-2874	867	7	)	)	PUNCT
admet-2874	867	8	(	(	PUNCT
admet-2874	867	9	2025	2025	NUM
admet-2874	867	10	)	)	PUNCT
admet-2874	867	11	25071	25071	NUM
admet-2874	867	12	-	-	SYM
admet-2874	867	13	25082	25082	NUM
admet-2874	867	14	.	.	PUNCT
admet-2874	868	1	https://doi.org/10.1021/acsami.5c02796	https://doi.org/10.1021/acsami.5c02796	PRON
admet-2874	868	2	151	151	NUM
admet-2874	868	3	.	.	PUNCT
admet-2874	868	4	x.	x.	PROPN
admet-2874	868	5	su	su	PROPN
admet-2874	868	6	,	,	PUNCT
admet-2874	868	7	h.	h.	PROPN
admet-2874	868	8	zhong	zhong	PROPN
admet-2874	868	9	,	,	PUNCT
admet-2874	868	10	y.	y.	PROPN
admet-2874	868	11	zeng	zeng	PROPN
admet-2874	868	12	,	,	PUNCT
admet-2874	868	13	y.	y.	PROPN
admet-2874	868	14	zhang	zhang	PROPN
admet-2874	868	15	,	,	PUNCT
admet-2874	868	16	b.	b.	PROPN
admet-2874	868	17	zhang	zhang	PROPN
admet-2874	868	18	,	,	PUNCT
admet-2874	868	19	w.	w.	PROPN
admet-2874	868	20	guo	guo	PROPN
admet-2874	868	21	,	,	PUNCT
admet-2874	868	22	q.	q.	PROPN
admet-2874	868	23	huang	huang	PROPN
admet-2874	868	24	,	,	PUNCT
admet-2874	868	25	y.	y.	PROPN
admet-2874	868	26	ye	ye	PROPN
admet-2874	868	27	.	.	PUNCT
admet-2874	869	1	dual	dual	ADJ
admet-2874	869	2	-	-	PUNCT
admet-2874	869	3	ligand	ligand	NOUN
admet-2874	869	4	-	-	PUNCT
admet-2874	869	5	functionalized	functionalize	VERB
admet-2874	869	6	nanostructured	nanostructure	VERB
admet-2874	869	7	lipid	lipid	NOUN
admet-2874	869	8	carriers	carrier	NOUN
admet-2874	869	9	as	as	ADP
admet-2874	869	10	a	a	DET
admet-2874	869	11	novel	novel	ADJ
admet-2874	869	12	dehydrocavidine	dehydrocavidine	ADJ
admet-2874	869	13	delivery	delivery	NOUN
admet-2874	869	14	system	system	NOUN
admet-2874	869	15	for	for	ADP
admet-2874	869	16	liver	liver	NOUN
admet-2874	869	17	fibrosis	fibrosis	NOUN
admet-2874	869	18	therapy	therapy	NOUN
admet-2874	869	19	.	.	PUNCT
admet-2874	870	1	colloids	colloid	NOUN
admet-2874	870	2	and	and	CCONJ
admet-2874	870	3	surfaces	surface	NOUN
admet-2874	870	4	b	b	X
admet-2874	870	5	246	246	NUM
admet-2874	870	6	(	(	PUNCT
admet-2874	870	7	2025	2025	NUM
admet-2874	870	8	)	)	PUNCT
admet-2874	870	9	114376	114376	NUM
admet-2874	870	10	.	.	PUNCT
admet-2874	871	1	https://doi.org/10.1016/j.colsurfb.2024.114376	https://doi.org/10.1016/j.colsurfb.2024.114376	VERB
admet-2874	871	2	152	152	NUM
admet-2874	871	3	.	.	PUNCT
admet-2874	872	1	h.	h.	PROPN
admet-2874	872	2	liu	liu	PROPN
admet-2874	872	3	,	,	PUNCT
admet-2874	872	4	y.	y.	PROPN
admet-2874	872	5	qi	qi	PROPN
admet-2874	872	6	,	,	PUNCT
admet-2874	872	7	l.	l.	PROPN
admet-2874	872	8	wang	wang	PROPN
admet-2874	872	9	,	,	PUNCT
admet-2874	872	10	y.	y.	PROPN
admet-2874	872	11	zhang	zhang	PROPN
admet-2874	872	12	,	,	PUNCT
admet-2874	872	13	h.	h.	PROPN
admet-2874	872	14	chen	chen	PROPN
admet-2874	872	15	,	,	PUNCT
admet-2874	872	16	y.	y.	PROPN
admet-2874	872	17	zhao	zhao	PROPN
admet-2874	872	18	,	,	PUNCT
admet-2874	872	19	h.	h.	PROPN
admet-2874	872	20	min	min	PROPN
admet-2874	872	21	,	,	PUNCT
admet-2874	872	22	g.	g.	PROPN
admet-2874	872	23	nie	nie	PROPN
admet-2874	872	24	,	,	PUNCT
admet-2874	872	25	h.	h.	PROPN
admet-2874	872	26	liang	liang	PROPN
admet-2874	872	27	.	.	PUNCT
admet-2874	873	1	lysosome	lysosome	PROPN
admet-2874	873	2	-	-	PUNCT
admet-2874	873	3	targeting	target	VERB
admet-2874	873	4	nanochimeras	nanochimera	NOUN
admet-2874	873	5	attenuating	attenuate	VERB
admet-2874	873	6	liver	liver	NOUN
admet-2874	873	7	fibrosis	fibrosis	NOUN
admet-2874	873	8	by	by	ADP
admet-2874	873	9	interconnected	interconnected	ADJ
admet-2874	873	10	transforming	transform	VERB
admet-2874	873	11	growth	growth	NOUN
admet-2874	873	12	factor	factor	NOUN
admet-2874	873	13	-	-	PUNCT
admet-2874	873	14	β	β	NOUN
admet-2874	873	15	reduction	reduction	NOUN
admet-2874	873	16	and	and	CCONJ
admet-2874	873	17	activin	activin	NOUN
admet-2874	873	18	receptor	receptor	NOUN
admet-2874	873	19	-	-	PUNCT
admet-2874	873	20	like	like	ADJ
admet-2874	873	21	kinase	kinase	NOUN
admet-2874	873	22	5	5	NUM
admet-2874	873	23	degradation	degradation	NOUN
admet-2874	873	24	.	.	PUNCT
admet-2874	874	1	acs	acs	PROPN
admet-2874	874	2	nano	nano	VERB
admet-2874	874	3	19	19	NUM
admet-2874	874	4	(	(	PUNCT
admet-2874	874	5	2025	2025	NUM
admet-2874	874	6	)	)	PUNCT
admet-2874	874	7	25645	25645	NUM
admet-2874	874	8	-	-	SYM
admet-2874	874	9	25661	25661	NUM
admet-2874	874	10	.	.	PUNCT
admet-2874	875	1	https://doi.org/10.1021/acsnano.5c00985	https://doi.org/10.1021/acsnano.5c00985	X
admet-2874	875	2	153	153	NUM
admet-2874	875	3	.	.	PUNCT
admet-2874	875	4	k.	k.	PROPN
admet-2874	875	5	togami	togami	PROPN
admet-2874	875	6	,	,	PUNCT
admet-2874	875	7	y.	y.	PROPN
admet-2874	875	8	kanehira	kanehira	PROPN
admet-2874	875	9	,	,	PUNCT
admet-2874	875	10	y.	y.	PROPN
admet-2874	875	11	nakamura	nakamura	PROPN
admet-2874	875	12	,	,	PUNCT
admet-2874	875	13	h.	h.	PROPN
admet-2874	875	14	ishii	ishii	PROPN
admet-2874	875	15	,	,	PUNCT
admet-2874	875	16	r.	r.	PROPN
admet-2874	875	17	abe	abe	PROPN
admet-2874	875	18	,	,	PUNCT
admet-2874	875	19	a.	a.	PROPN
admet-2874	875	20	yamamoto	yamamoto	PROPN
admet-2874	875	21	,	,	PUNCT
admet-2874	875	22	k.	k.	PROPN
admet-2874	875	23	takehara	takehara	PROPN
admet-2874	875	24	,	,	PUNCT
admet-2874	875	25	m.	m.	NOUN
admet-2874	875	26	yasuda	yasuda	PROPN
admet-2874	875	27	,	,	PUNCT
admet-2874	875	28	h.	h.	PROPN
admet-2874	875	29	tada	tada	PROPN
admet-2874	875	30	,	,	PUNCT
admet-2874	875	31	s.	s.	PROPN
admet-2874	875	32	chono	chono	PROPN
admet-2874	875	33	.	.	PUNCT
admet-2874	876	1	pirfenidone	pirfenidone	NOUN
admet-2874	876	2	encapsulated	encapsulate	VERB
admet-2874	876	3	in	in	ADP
admet-2874	876	4	succinylated	succinylate	VERB
admet-2874	876	5	gelatin	gelatin	NOUN
admet-2874	876	6	-	-	PUNCT
admet-2874	876	7	coated	coat	VERB
admet-2874	876	8	liposomes	liposome	NOUN
admet-2874	876	9	exhibits	exhibit	VERB
admet-2874	876	10	https://doi.org/10.7150/thno.37301	https://doi.org/10.7150/thno.37301	NOUN
admet-2874	876	11	https://doi.org/10.1021/acsami.0c23137	https://doi.org/10.1021/acsami.0c23137	PROPN
admet-2874	876	12	https://doi.org/10.1021/acsami.2c19269	https://doi.org/10.1021/acsami.2c19269	ADP
admet-2874	876	13	https://doi.org/10.1021/acsami.3c17670	https://doi.org/10.1021/acsami.3c17670	PROPN
admet-2874	876	14	https://doi.org/10.1016/j.cclet.2023.108803	https://doi.org/10.1016/j.cclet.2023.108803	VERB
admet-2874	876	15	https://doi.org/10.2147/ijn.s373430	https://doi.org/10.2147/ijn.s373430	PROPN
admet-2874	876	16	https://doi.org/10.1016/j.colsurfb.2024.114376	https://doi.org/10.1016/j.colsurfb.2024.114376	VERB
admet-2874	876	17	https://doi.org/10.1021/acsnano.5c00136	https://doi.org/10.1021/acsnano.5c00136	ADJ
admet-2874	876	18	https://doi.org/10.1021/acsami.5c02796	https://doi.org/10.1021/acsami.5c02796	PRON
admet-2874	876	19	https://doi.org/10.1016/j.colsurfb.2024.114376	https://doi.org/10.1016/j.colsurfb.2024.114376	VERB
admet-2874	876	20	https://doi.org/10.1021/acsnano.5c00985	https://doi.org/10.1021/acsnano.5c00985	PRON
admet-2874	876	21	admet	admet	PROPN
admet-2874	876	22	&	&	CCONJ
admet-2874	876	23	dmpk	dmpk	PROPN
admet-2874	876	24	13(4	13(4	NUM
admet-2874	876	25	)	)	PUNCT
admet-2874	876	26	(	(	PUNCT
admet-2874	876	27	2025	2025	NUM
admet-2874	876	28	)	)	PUNCT
admet-2874	876	29	2874	2874	NUM
admet-2874	876	30	hscs	hsc	NOUN
admet-2874	876	31	in	in	ADP
admet-2874	876	32	liver	liver	NOUN
admet-2874	876	33	fibrosis	fibrosis	NOUN
admet-2874	876	34	:	:	PUNCT
admet-2874	876	35	therapeutic	therapeutic	ADJ
admet-2874	876	36	advances	advance	NOUN
admet-2874	876	37	doi	doi	NOUN
admet-2874	876	38	:	:	PUNCT
admet-2874	876	39	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PUNCT
admet-2874	876	40	27	27	NUM
admet-2874	876	41	sustained	sustain	VERB
admet-2874	876	42	antifibrotic	antifibrotic	ADJ
admet-2874	876	43	effects	effect	NOUN
admet-2874	876	44	in	in	ADP
admet-2874	876	45	vitro	vitro	X
admet-2874	876	46	models	model	NOUN
admet-2874	876	47	of	of	ADP
admet-2874	876	48	renal	renal	ADJ
admet-2874	876	49	,	,	PUNCT
admet-2874	876	50	pulmonary	pulmonary	ADJ
admet-2874	876	51	,	,	PUNCT
admet-2874	876	52	and	and	CCONJ
admet-2874	876	53	hepatic	hepatic	ADJ
admet-2874	876	54	fibrosis	fibrosis	NOUN
admet-2874	876	55	.	.	PUNCT
admet-2874	877	1	journal	journal	NOUN
admet-2874	877	2	of	of	ADP
admet-2874	877	3	pharmacetical	pharmacetical	ADJ
admet-2874	877	4	sciences	science	NOUN
admet-2874	877	5	114	114	NUM
admet-2874	877	6	(	(	PUNCT
admet-2874	877	7	2025	2025	NUM
admet-2874	877	8	)	)	PUNCT
admet-2874	877	9	103819	103819	NUM
admet-2874	877	10	.	.	PUNCT
admet-2874	878	1	https://doi.org/10.1016/j.xphs.2025.103819	https://doi.org/10.1016/j.xphs.2025.103819	PROPN
admet-2874	878	2	154	154	NUM
admet-2874	878	3	.	.	PUNCT
admet-2874	879	1	x.	x.	PROPN
admet-2874	879	2	liu	liu	PROPN
admet-2874	879	3	,	,	PUNCT
admet-2874	879	4	c.	c.	PROPN
admet-2874	879	5	fang	fang	PROPN
admet-2874	879	6	,	,	PUNCT
admet-2874	879	7	h.	h.	PROPN
admet-2874	879	8	yu	yu	PROPN
admet-2874	879	9	,	,	PUNCT
admet-2874	879	10	l.	l.	PROPN
admet-2874	879	11	huang	huang	PROPN
admet-2874	879	12	,	,	PUNCT
admet-2874	879	13	j.	j.	PROPN
admet-2874	879	14	feng	feng	PROPN
admet-2874	879	15	,	,	PUNCT
admet-2874	879	16	s.	s.	PROPN
admet-2874	879	17	luo	luo	PROPN
admet-2874	879	18	,	,	PUNCT
admet-2874	879	19	l.	l.	PROPN
admet-2874	879	20	song	song	PROPN
admet-2874	879	21	,	,	PUNCT
admet-2874	879	22	m.	m.	PROPN
admet-2874	879	23	wu	wu	PROPN
admet-2874	879	24	,	,	PUNCT
admet-2874	879	25	y.	y.	PROPN
admet-2874	879	26	tan	tan	PROPN
admet-2874	879	27	,	,	PUNCT
admet-2874	879	28	j.	j.	PROPN
admet-2874	879	29	dong	dong	PROPN
admet-2874	879	30	,	,	PUNCT
admet-2874	879	31	t.	t.	PROPN
admet-2874	879	32	gong	gong	PROPN
admet-2874	879	33	,	,	PUNCT
admet-2874	879	34	p.	p.	PROPN
admet-2874	879	35	xiao	xiao	PROPN
admet-2874	879	36	.	.	PUNCT
admet-2874	880	1	chondroitin	chondroitin	PROPN
admet-2874	880	2	sulfate	sulfate	NOUN
admet-2874	880	3	-	-	PUNCT
admet-2874	880	4	based	base	VERB
admet-2874	880	5	imatinib	imatinib	NOUN
admet-2874	880	6	nanoparticles	nanoparticle	NOUN
admet-2874	880	7	targeting	target	VERB
admet-2874	880	8	activated	activate	VERB
admet-2874	880	9	hepatic	hepatic	ADJ
admet-2874	880	10	stellate	stellate	ADJ
admet-2874	880	11	cells	cell	NOUN
admet-2874	880	12	against	against	ADP
admet-2874	880	13	hepatic	hepatic	ADJ
admet-2874	880	14	fibrosis	fibrosis	NOUN
admet-2874	880	15	.	.	PUNCT
admet-2874	881	1	pharmaceutics	pharmaceutic	NOUN
admet-2874	881	2	17	17	NUM
admet-2874	881	3	(	(	PUNCT
admet-2874	881	4	2025	2025	NUM
admet-2874	881	5	)	)	PUNCT
admet-2874	881	6	351	351	NUM
admet-2874	881	7	.	.	PUNCT
admet-2874	881	8	https://doi.org/10.3390/pharmaceutics17030351	https://doi.org/10.3390/pharmaceutics17030351	NOUN
admet-2874	881	9	155	155	NUM
admet-2874	881	10	.	.	PUNCT
admet-2874	882	1	m.	m.	PROPN
admet-2874	882	2	lu	lu	PROPN
admet-2874	882	3	,	,	PUNCT
admet-2874	882	4	z.	z.	PROPN
admet-2874	882	5	dai	dai	PROPN
admet-2874	882	6	,	,	PUNCT
admet-2874	882	7	y.	y.	PROPN
admet-2874	882	8	lin	lin	PROPN
admet-2874	882	9	,	,	PUNCT
admet-2874	882	10	c.	c.	PROPN
admet-2874	882	11	sun	sun	PROPN
admet-2874	882	12	,	,	PUNCT
admet-2874	882	13	s.	s.	PROPN
admet-2874	882	14	li	li	PROPN
admet-2874	882	15	,	,	PUNCT
admet-2874	882	16	z.	z.	PROPN
admet-2874	882	17	guo	guo	PROPN
admet-2874	882	18	,	,	PUNCT
admet-2874	882	19	y.	y.	PROPN
admet-2874	882	20	liu	liu	PROPN
admet-2874	882	21	,	,	PUNCT
admet-2874	882	22	x.	x.	PROPN
admet-2874	882	23	liu	liu	PROPN
admet-2874	882	24	,	,	PUNCT
admet-2874	882	25	s.	s.	PROPN
admet-2874	882	26	li	li	PROPN
admet-2874	882	27	,	,	PUNCT
admet-2874	882	28	r.	r.	PROPN
admet-2874	882	29	liu	liu	PROPN
admet-2874	882	30	,	,	PUNCT
admet-2874	882	31	b.	b.	PROPN
admet-2874	882	32	xu	xu	PROPN
admet-2874	882	33	,	,	PUNCT
admet-2874	882	34	h.	h.	PROPN
admet-2874	882	35	lei	lei	PROPN
admet-2874	882	36	.	.	PUNCT
admet-2874	883	1	co	co	VERB
admet-2874	883	2	-	-	VERB
admet-2874	883	3	assembled	assemble	VERB
admet-2874	883	4	nanoparticles	nanoparticle	NOUN
admet-2874	883	5	comprising	comprise	VERB
admet-2874	883	6	sorafenib	sorafenib	NOUN
admet-2874	883	7	and	and	CCONJ
admet-2874	883	8	hederagenin	hederagenin	ADJ
admet-2874	883	9	derivative	derivative	NOUN
admet-2874	883	10	for	for	ADP
admet-2874	883	11	enhanced	enhance	VERB
admet-2874	883	12	anti	anti	ADJ
admet-2874	883	13	-	-	ADJ
admet-2874	883	14	hepatic	hepatic	ADJ
admet-2874	883	15	fibrosis	fibrosis	NOUN
admet-2874	883	16	activity	activity	NOUN
admet-2874	883	17	.	.	PUNCT
admet-2874	884	1	international	international	ADJ
admet-2874	884	2	journal	journal	PROPN
admet-2874	884	3	of	of	ADP
admet-2874	884	4	nanomedicine	nanomedicine	ADJ
admet-2874	884	5	20	20	NUM
admet-2874	884	6	(	(	PUNCT
admet-2874	884	7	2025	2025	NUM
admet-2874	884	8	)	)	PUNCT
admet-2874	884	9	9135	9135	NUM
admet-2874	884	10	-	-	SYM
admet-2874	884	11	9153	9153	NUM
admet-2874	884	12	.	.	PUNCT
admet-2874	885	1	https://doi.org/10.2147/ijn.s512005	https://doi.org/10.2147/ijn.s512005	X
admet-2874	885	2	156	156	NUM
admet-2874	885	3	.	.	PUNCT
admet-2874	886	1	r.	r.	PROPN
admet-2874	886	2	yang	yang	PROPN
admet-2874	886	3	,	,	PUNCT
admet-2874	886	4	l.	l.	PROPN
admet-2874	886	5	yang	yang	PROPN
admet-2874	886	6	,	,	PUNCT
admet-2874	886	7	n.	n.	PROPN
admet-2874	886	8	zhang	zhang	PROPN
admet-2874	886	9	,	,	PUNCT
admet-2874	886	10	y.	y.	PROPN
admet-2874	886	11	wan	wan	PROPN
admet-2874	886	12	,	,	PUNCT
admet-2874	886	13	s.	s.	PROPN
admet-2874	886	14	chen	chen	PROPN
admet-2874	886	15	,	,	PUNCT
admet-2874	886	16	y.	y.	PROPN
admet-2874	886	17	xiao	xiao	PROPN
admet-2874	886	18	,	,	PUNCT
admet-2874	886	19	x.	x.	PROPN
admet-2874	886	20	liang	liang	PROPN
admet-2874	886	21	,	,	PUNCT
admet-2874	886	22	s.	s.	PROPN
admet-2874	886	23	yang	yang	PROPN
admet-2874	886	24	,	,	PUNCT
admet-2874	886	25	y.	y.	PROPN
admet-2874	886	26	zhong	zhong	PROPN
admet-2874	886	27	,	,	PUNCT
admet-2874	886	28	d.	d.	PROPN
admet-2874	886	29	huang	huang	PROPN
admet-2874	886	30	,	,	PUNCT
admet-2874	886	31	w.	w.	PROPN
admet-2874	886	32	chen	chen	PROPN
admet-2874	886	33	,	,	PUNCT
admet-2874	886	34	b.	b.	PROPN
admet-2874	886	35	zhao	zhao	PROPN
admet-2874	886	36	.	.	PUNCT
admet-2874	887	1	targeted	target	VERB
admet-2874	887	2	delivery	delivery	NOUN
admet-2874	887	3	of	of	ADP
admet-2874	887	4	polymeric	polymeric	ADJ
admet-2874	887	5	no	no	DET
admet-2874	887	6	-	-	PUNCT
admet-2874	887	7	donor	donor	NOUN
admet-2874	887	8	micelles	micelle	NOUN
admet-2874	887	9	to	to	ADP
admet-2874	887	10	hepatic	hepatic	ADJ
admet-2874	887	11	stellate	stellate	ADJ
admet-2874	887	12	cells	cell	NOUN
admet-2874	887	13	for	for	ADP
admet-2874	887	14	restoration	restoration	NOUN
admet-2874	887	15	of	of	ADP
admet-2874	887	16	liver	liver	NOUN
admet-2874	887	17	function	function	NOUN
admet-2874	887	18	and	and	CCONJ
admet-2874	887	19	inhibition	inhibition	NOUN
admet-2874	887	20	of	of	ADP
admet-2874	887	21	hepatic	hepatic	ADJ
admet-2874	887	22	fibrosis	fibrosis	NOUN
admet-2874	887	23	.	.	PUNCT
admet-2874	888	1	journal	journal	PROPN
admet-2874	888	2	of	of	ADP
admet-2874	888	3	controlled	control	VERB
admet-2874	888	4	release	release	NOUN
admet-2874	888	5	379	379	NUM
admet-2874	888	6	(	(	PUNCT
admet-2874	888	7	2025	2025	NUM
admet-2874	888	8	)	)	PUNCT
admet-2874	888	9	466	466	NUM
admet-2874	888	10	-	-	PUNCT
admet-2874	888	11	477	477	NUM
admet-2874	888	12	.	.	PUNCT
admet-2874	889	1	https://doi.org/10.1016/j.jconrel.2025.01.036	https://doi.org/10.1016/j.jconrel.2025.01.036	NOUN
admet-2874	889	2	157	157	NUM
admet-2874	889	3	.	.	PUNCT
admet-2874	890	1	m.k	m.k	PROPN
admet-2874	890	2	.	.	PROPN
admet-2874	890	3	mohsen	mohsen	PROPN
admet-2874	890	4	,	,	PUNCT
admet-2874	890	5	s.a.e	s.a.e	PROPN
admet-2874	890	6	.	.	PUNCT
admet-2874	891	1	azm	azm	PROPN
admet-2874	891	2	diab	diab	PROPN
admet-2874	891	3	,	,	PUNCT
admet-2874	891	4	a.n	a.n	PROPN
admet-2874	891	5	.	.	PROPN
admet-2874	891	6	shafik	shafik	PROPN
admet-2874	891	7	,	,	PUNCT
admet-2874	891	8	a.h	a.h	PROPN
admet-2874	891	9	.	.	PROPN
admet-2874	891	10	osman	osman	PROPN
admet-2874	891	11	,	,	PUNCT
admet-2874	891	12	m.j	m.j	PROPN
admet-2874	891	13	.	.	PROPN
admet-2874	891	14	naguib	naguib	PROPN
admet-2874	891	15	,	,	PUNCT
admet-2874	891	16	a.m.	a.m.	PROPN
admet-2874	891	17	kamel	kamel	PROPN
admet-2874	891	18	,	,	PUNCT
admet-2874	891	19	m.n	m.n	PROPN
admet-2874	891	20	.	.	PROPN
admet-2874	891	21	mehesen	mehesen	PROPN
admet-2874	891	22	.	.	PUNCT
admet-2874	892	1	sofosbuvir	sofosbuvir	PROPN
admet-2874	892	2	’s	’s	PART
admet-2874	892	3	hepatoprotective	hepatoprotective	ADJ
admet-2874	892	4	efficacy	efficacy	NOUN
admet-2874	892	5	in	in	ADP
admet-2874	892	6	rats	rat	NOUN
admet-2874	892	7	is	be	AUX
admet-2874	892	8	enhanced	enhance	VERB
admet-2874	892	9	by	by	ADP
admet-2874	892	10	encapsulating	encapsulate	VERB
admet-2874	892	11	in	in	ADP
admet-2874	892	12	taurocholate	taurocholate	NOUN
admet-2874	892	13	-	-	PUNCT
admet-2874	892	14	stabilized	stabilize	VERB
admet-2874	892	15	galactose	galactose	NOUN
admet-2874	892	16	-	-	PUNCT
admet-2874	892	17	anchored	anchor	VERB
admet-2874	892	18	bilosomes	bilosome	NOUN
admet-2874	892	19	.	.	PUNCT
admet-2874	893	1	future	future	ADJ
admet-2874	893	2	journal	journal	PROPN
admet-2874	893	3	of	of	ADP
admet-2874	893	4	pharmaceutical	pharmaceutical	ADJ
admet-2874	893	5	sciences	science	NOUN
admet-2874	893	6	11	11	NUM
admet-2874	893	7	(	(	PUNCT
admet-2874	893	8	2025	2025	NUM
admet-2874	893	9	)	)	PUNCT
admet-2874	893	10	21	21	NUM
admet-2874	893	11	.	.	PUNCT
admet-2874	894	1	https://doi.org/10.1186/s43094-025-00775-w	https://doi.org/10.1186/s43094-025-00775-w	VERB
admet-2874	894	2	158	158	NUM
admet-2874	894	3	.	.	PUNCT
admet-2874	895	1	a.	a.	PROPN
admet-2874	895	2	mokhtariye	mokhtariye	PROPN
admet-2874	895	3	,	,	PUNCT
admet-2874	895	4	j.	j.	PROPN
admet-2874	895	5	varshosaz	varshosaz	PROPN
admet-2874	895	6	,	,	PUNCT
admet-2874	895	7	a.	a.	NOUN
admet-2874	895	8	mohammadalipour	mohammadalipour	PROPN
admet-2874	895	9	,	,	PUNCT
admet-2874	895	10	m.	m.	NOUN
admet-2874	895	11	hashemnia	hashemnia	PROPN
admet-2874	895	12	,	,	PUNCT
admet-2874	895	13	m.r	m.r	PROPN
admet-2874	895	14	.	.	PROPN
admet-2874	895	15	mofid	mofid	PROPN
admet-2874	895	16	.	.	PUNCT
admet-2874	896	1	xanthosomes	xanthosomes	PROPN
admet-2874	896	2	loaded	load	VERB
admet-2874	896	3	with	with	ADP
admet-2874	896	4	recombinant	recombinant	ADJ
admet-2874	896	5	tmem219	tmem219	PROPN
admet-2874	896	6	for	for	ADP
admet-2874	896	7	targeting	target	VERB
admet-2874	896	8	igfbp-3	igfbp-3	PRON
admet-2874	896	9	:	:	PUNCT
admet-2874	896	10	a	a	DET
admet-2874	896	11	novel	novel	ADJ
admet-2874	896	12	approach	approach	NOUN
admet-2874	896	13	for	for	ADP
admet-2874	896	14	targeted	target	VERB
admet-2874	896	15	drug	drug	NOUN
admet-2874	896	16	delivery	delivery	NOUN
admet-2874	896	17	to	to	PART
admet-2874	896	18	ameliorate	ameliorate	VERB
admet-2874	896	19	liver	liver	NOUN
admet-2874	896	20	fibrosis	fibrosis	NOUN
admet-2874	896	21	.	.	PUNCT
admet-2874	897	1	life	life	NOUN
admet-2874	897	2	sciences	science	NOUN
admet-2874	897	3	377	377	NUM
admet-2874	897	4	(	(	PUNCT
admet-2874	897	5	2025	2025	NUM
admet-2874	897	6	)	)	PUNCT
admet-2874	897	7	123748	123748	NUM
admet-2874	897	8	.	.	PUNCT
admet-2874	898	1	https://doi.org/10.1016/j.lfs.2025.123748	https://doi.org/10.1016/j.lfs.2025.123748	PROPN
admet-2874	898	2	159	159	NUM
admet-2874	898	3	.	.	PUNCT
admet-2874	899	1	r.	r.	PROPN
admet-2874	899	2	li	li	PROPN
admet-2874	899	3	,	,	PUNCT
admet-2874	899	4	y.	y.	PROPN
admet-2874	899	5	tai	tai	PROPN
admet-2874	899	6	,	,	PUNCT
admet-2874	899	7	x.	x.	PROPN
admet-2874	899	8	zhang	zhang	PROPN
admet-2874	899	9	,	,	PUNCT
admet-2874	899	10	z.	z.	PROPN
admet-2874	899	11	liu	liu	PROPN
admet-2874	899	12	,	,	PUNCT
admet-2874	899	13	h.	h.	PROPN
admet-2874	899	14	si	si	PROPN
admet-2874	899	15	,	,	PUNCT
admet-2874	899	16	d.	d.	PROPN
admet-2874	899	17	kong	kong	PROPN
admet-2874	899	18	,	,	PUNCT
admet-2874	899	19	l.	l.	PROPN
admet-2874	899	20	zhao	zhao	PROPN
admet-2874	899	21	,	,	PUNCT
admet-2874	899	22	j.	j.	PROPN
admet-2874	899	23	li	li	PROPN
admet-2874	899	24	,	,	PUNCT
admet-2874	899	25	a.c	a.c	PROPN
admet-2874	899	26	.	.	PROPN
admet-2874	899	27	midgley	midgley	PROPN
admet-2874	899	28	.	.	PUNCT
admet-2874	900	1	tissuemicroenvironment	tissuemicroenvironment	ADJ
admet-2874	900	2	-	-	PUNCT
admet-2874	900	3	responsive	responsive	ADJ
admet-2874	900	4	self	self	NOUN
admet-2874	900	5	-	-	PUNCT
admet-2874	900	6	assembling	assemble	VERB
admet-2874	900	7	peptide	peptide	NOUN
admet-2874	900	8	nanoshells	nanoshell	NOUN
admet-2874	900	9	boost	boost	VERB
admet-2874	900	10	pirfenidone	pirfenidone	NOUN
admet-2874	900	11	efficacy	efficacy	NOUN
admet-2874	900	12	in	in	ADP
admet-2874	900	13	the	the	DET
admet-2874	900	14	treatment	treatment	NOUN
admet-2874	900	15	of	of	ADP
admet-2874	900	16	liver	liver	NOUN
admet-2874	900	17	fibrosis	fibrosis	NOUN
admet-2874	900	18	.	.	PUNCT
admet-2874	901	1	advanced	advanced	ADJ
admet-2874	901	2	healthcare	healthcare	NOUN
admet-2874	901	3	materials	material	NOUN
admet-2874	901	4	14	14	NUM
admet-2874	901	5	(	(	PUNCT
admet-2874	901	6	2025	2025	NUM
admet-2874	901	7	)	)	PUNCT
admet-2874	901	8	2500101	2500101	NUM
admet-2874	901	9	.	.	PUNCT
admet-2874	902	1	https://doi.org/10.1002/adhm.202500101	https://doi.org/10.1002/adhm.202500101	PROPN
admet-2874	902	2	160	160	NUM
admet-2874	902	3	.	.	PUNCT
admet-2874	903	1	x.	x.	PROPN
admet-2874	903	2	xiang	xiang	PROPN
admet-2874	903	3	,	,	PUNCT
admet-2874	903	4	y.	y.	PROPN
admet-2874	903	5	shao	shao	PROPN
admet-2874	903	6	,	,	PUNCT
admet-2874	903	7	l.	l.	PROPN
admet-2874	903	8	xiang	xiang	PROPN
admet-2874	903	9	,	,	PUNCT
admet-2874	903	10	q.	q.	PROPN
admet-2874	903	11	jiao	jiao	PROPN
admet-2874	903	12	,	,	PUNCT
admet-2874	903	13	w.	w.	PROPN
admet-2874	903	14	zhang	zhang	PROPN
admet-2874	903	15	,	,	PUNCT
admet-2874	903	16	y.	y.	PROPN
admet-2874	903	17	qin	qin	PROPN
admet-2874	903	18	,	,	PUNCT
admet-2874	903	19	y.	y.	PROPN
admet-2874	903	20	chen	chen	PROPN
admet-2874	903	21	.	.	PUNCT
admet-2874	904	1	suppression	suppression	NOUN
admet-2874	904	2	of	of	ADP
admet-2874	904	3	liver	liver	NOUN
admet-2874	904	4	fibrogenesis	fibrogenesis	NOUN
admet-2874	904	5	with	with	ADP
admet-2874	904	6	photothermal	photothermal	ADJ
admet-2874	904	7	sorafenib	sorafenib	NOUN
admet-2874	904	8	nanovesicles	nanovesicle	NOUN
admet-2874	904	9	via	via	ADP
admet-2874	904	10	selectively	selectively	ADV
admet-2874	904	11	inhibiting	inhibit	VERB
admet-2874	904	12	glycolysis	glycolysis	NOUN
admet-2874	904	13	and	and	CCONJ
admet-2874	904	14	amplification	amplification	NOUN
admet-2874	904	15	of	of	ADP
admet-2874	904	16	active	active	ADJ
admet-2874	904	17	hscs	hsc	NOUN
admet-2874	904	18	.	.	PUNCT
admet-2874	905	1	molecular	molecular	ADJ
admet-2874	905	2	pharmaceutics	pharmaceutic	NOUN
admet-2874	905	3	22	22	NUM
admet-2874	905	4	(	(	PUNCT
admet-2874	905	5	2025	2025	NUM
admet-2874	905	6	)	)	PUNCT
admet-2874	905	7	1939	1939	NUM
admet-2874	905	8	-	-	SYM
admet-2874	905	9	1957	1957	NUM
admet-2874	905	10	.	.	PUNCT
admet-2874	906	1	https://doi.org/10.1021/acs.molpharmaceut.4c01135	https://doi.org/10.1021/acs.molpharmaceut.4c01135	PRON
admet-2874	906	2	161	161	NUM
admet-2874	906	3	.	.	PUNCT
admet-2874	906	4	x.	x.	PROPN
admet-2874	906	5	liu	liu	PROPN
admet-2874	906	6	,	,	PUNCT
admet-2874	906	7	x.	x.	NOUN
admet-2874	906	8	mu	mu	PROPN
admet-2874	906	9	,	,	PUNCT
admet-2874	906	10	y.	y.	PROPN
admet-2874	906	11	wang	wang	PROPN
admet-2874	906	12	,	,	PUNCT
admet-2874	906	13	z.	z.	PROPN
admet-2874	906	14	liu	liu	PROPN
admet-2874	906	15	,	,	PUNCT
admet-2874	906	16	y.	y.	PROPN
admet-2874	906	17	li	li	PROPN
admet-2874	906	18	,	,	PUNCT
admet-2874	906	19	j.	j.	PROPN
admet-2874	906	20	lan	lan	PROPN
admet-2874	906	21	,	,	PUNCT
admet-2874	906	22	s.	s.	PROPN
admet-2874	906	23	feng	feng	PROPN
admet-2874	906	24	,	,	PUNCT
admet-2874	906	25	s.	s.	PROPN
admet-2874	906	26	wang	wang	PROPN
admet-2874	906	27	,	,	PUNCT
admet-2874	906	28	q.	q.	PROPN
admet-2874	906	29	zhao	zhao	PROPN
admet-2874	906	30	.	.	PUNCT
admet-2874	907	1	metal	metal	NOUN
admet-2874	907	2	-	-	PUNCT
admet-2874	907	3	based	base	VERB
admet-2874	907	4	mesoporous	mesoporous	ADJ
admet-2874	907	5	polydopamine	polydopamine	NOUN
admet-2874	907	6	with	with	ADP
admet-2874	907	7	dual	dual	ADJ
admet-2874	907	8	enzyme	enzyme	NOUN
admet-2874	907	9	-	-	PUNCT
admet-2874	907	10	like	like	ADJ
admet-2874	907	11	activity	activity	NOUN
admet-2874	907	12	as	as	ADP
admet-2874	907	13	biomimetic	biomimetic	ADJ
admet-2874	907	14	nanodrug	nanodrug	NOUN
admet-2874	907	15	for	for	ADP
admet-2874	907	16	alleviating	alleviate	VERB
admet-2874	907	17	liver	liver	NOUN
admet-2874	907	18	fibrosis	fibrosis	NOUN
admet-2874	907	19	.	.	PUNCT
admet-2874	908	1	journal	journal	PROPN
admet-2874	908	2	of	of	ADP
admet-2874	908	3	colloid	colloid	NOUN
admet-2874	908	4	and	and	CCONJ
admet-2874	908	5	interface	interface	NOUN
admet-2874	908	6	science	science	NOUN
admet-2874	908	7	684	684	NUM
admet-2874	908	8	(	(	PUNCT
admet-2874	908	9	2025	2025	NUM
admet-2874	908	10	)	)	PUNCT
admet-2874	908	11	586	586	NUM
admet-2874	908	12	-	-	SYM
admet-2874	908	13	599	599	NUM
admet-2874	908	14	.	.	PUNCT
admet-2874	909	1	https://doi.org/10.1016/j.jcis.2025.01.081	https://doi.org/10.1016/j.jcis.2025.01.081	NUM
admet-2874	909	2	©	©	PROPN
admet-2874	909	3	2025	2025	NUM
admet-2874	909	4	by	by	ADP
admet-2874	909	5	the	the	DET
admet-2874	909	6	authors	author	NOUN
admet-2874	909	7	;	;	PUNCT
admet-2874	909	8	licensee	licensee	PROPN
admet-2874	909	9	iapc	iapc	PROPN
admet-2874	909	10	,	,	PUNCT
admet-2874	909	11	zagreb	zagreb	PROPN
admet-2874	909	12	,	,	PUNCT
admet-2874	909	13	croatia	croatia	PROPN
admet-2874	909	14	.	.	PUNCT
admet-2874	910	1	this	this	DET
admet-2874	910	2	article	article	NOUN
admet-2874	910	3	is	be	AUX
admet-2874	910	4	an	an	DET
admet-2874	910	5	open	open	ADJ
admet-2874	910	6	-	-	PUNCT
admet-2874	910	7	access	access	NOUN
admet-2874	910	8	article	article	NOUN
admet-2874	910	9	distributed	distribute	VERB
admet-2874	910	10	under	under	ADP
admet-2874	910	11	the	the	DET
admet-2874	910	12	terms	term	NOUN
admet-2874	910	13	and	and	CCONJ
admet-2874	910	14	conditions	condition	NOUN
admet-2874	910	15	of	of	ADP
admet-2874	910	16	the	the	DET
admet-2874	910	17	creative	creative	ADJ
admet-2874	910	18	commons	common	NOUN
admet-2874	910	19	attribution	attribution	NOUN
admet-2874	910	20	license	license	NOUN
admet-2874	910	21	(	(	PUNCT
admet-2874	910	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2874	910	23	)	)	PUNCT
admet-2874	910	24	https://doi.org/10.5599/admet.2874	https://doi.org/10.5599/admet.2874	PART
admet-2874	910	25	https://doi.org/10.1016/j.xphs.2025.103819	https://doi.org/10.1016/j.xphs.2025.103819	PROPN
admet-2874	910	26	https://doi.org/10.3390/pharmaceutics17030351	https://doi.org/10.3390/pharmaceutics17030351	NOUN
admet-2874	910	27	https://doi.org/10.2147/ijn.s512005	https://doi.org/10.2147/ijn.s512005	X
admet-2874	910	28	https://doi.org/10.1016/j.jconrel.2025.01.036	https://doi.org/10.1016/j.jconrel.2025.01.036	NOUN
admet-2874	910	29	https://doi.org/10.1186/s43094-025-00775-w	https://doi.org/10.1186/s43094-025-00775-w	VERB
admet-2874	910	30	https://doi.org/10.1016/j.lfs.2025.123748	https://doi.org/10.1016/j.lfs.2025.123748	PROPN
admet-2874	910	31	https://doi.org/10.1002/adhm.202500101	https://doi.org/10.1002/adhm.202500101	PRON
admet-2874	910	32	https://doi.org/10.1021/acs.molpharmaceut.4c01135	https://doi.org/10.1021/acs.molpharmaceut.4c01135	NUM
admet-2874	910	33	https://doi.org/10.1016/j.jcis.2025.01.081	https://doi.org/10.1016/j.jcis.2025.01.081	PRON
admet-2874	910	34	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN