id	sid	tid	token	lemma	pos
admet-291	1	1	manuscript	manuscript	PROPN
admet-291	1	2	doi	doi	PROPN
admet-291	1	3	:	:	PUNCT
admet-291	1	4	10.5599	10.5599	NUM
admet-291	1	5	/	/	SYM
admet-291	1	6	admet.4.2.291	admet.4.2.291	DET
admet-291	1	7	98	98	NUM
admet-291	1	8	admet	admet	X
admet-291	1	9	&	&	CCONJ
admet-291	1	10	dmpk	dmpk	PROPN
admet-291	1	11	4(2	4(2	NUM
admet-291	1	12	)	)	PUNCT
admet-291	1	13	(	(	PUNCT
admet-291	1	14	2016	2016	NUM
admet-291	1	15	)	)	PUNCT
admet-291	1	16	98	98	NUM
admet-291	1	17	-	-	SYM
admet-291	1	18	113	113	NUM
admet-291	1	19	;	;	PUNCT
admet-291	1	20	doi	doi	NOUN
admet-291	1	21	:	:	PUNCT
admet-291	1	22	10.5599	10.5599	NUM
admet-291	1	23	/	/	SYM
admet-291	1	24	admet.4.2.291	admet.4.2.291	PRON
admet-291	1	25	open	open	ADJ
admet-291	1	26	access	access	NOUN
admet-291	1	27	:	:	PUNCT
admet-291	1	28	issn	issn	PROPN
admet-291	1	29	:	:	PUNCT
admet-291	1	30	1848	1848	NUM
admet-291	1	31	-	-	SYM
admet-291	1	32	7718	7718	NUM
admet-291	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-291	1	34	original	original	ADJ
admet-291	1	35	scientific	scientific	ADJ
admet-291	1	36	paper	paper	NOUN
admet-291	1	37	defining	define	VERB
admet-291	1	38	desirable	desirable	ADJ
admet-291	1	39	natural	natural	ADJ
admet-291	1	40	product	product	NOUN
admet-291	1	41	derived	derive	VERB
admet-291	1	42	anticancer	anticancer	NOUN
admet-291	1	43	drug	drug	NOUN
admet-291	1	44	space	space	NOUN
admet-291	1	45	:	:	PUNCT
admet-291	1	46	optimization	optimization	NOUN
admet-291	1	47	of	of	ADP
admet-291	1	48	molecular	molecular	ADJ
admet-291	1	49	physicochemical	physicochemical	ADJ
admet-291	1	50	properties	property	NOUN
admet-291	1	51	and	and	CCONJ
admet-291	1	52	admet	admet	PROPN
admet-291	1	53	attributes	attribute	VERB
admet-291	1	54	deepika	deepika	PROPN
admet-291	1	55	singh	singh	PROPN
admet-291	1	56	medicinal	medicinal	PROPN
admet-291	1	57	chemistry	chemistry	NOUN
admet-291	1	58	division	division	NOUN
admet-291	1	59	,	,	PUNCT
admet-291	1	60	central	central	PROPN
admet-291	1	61	institute	institute	PROPN
admet-291	1	62	of	of	ADP
admet-291	1	63	medicinal	medicinal	ADJ
admet-291	1	64	and	and	CCONJ
admet-291	1	65	aromatic	aromatic	ADJ
admet-291	1	66	plants	plant	NOUN
admet-291	1	67	,	,	PUNCT
admet-291	1	68	po	po	NOUN
admet-291	1	69	cimap	cimap	NOUN
admet-291	1	70	,	,	PUNCT
admet-291	1	71	lucknow	lucknow	PROPN
admet-291	1	72	226015	226015	NUM
admet-291	1	73	,	,	PUNCT
admet-291	1	74	india	india	PROPN
admet-291	1	75	corresponding	corresponding	PROPN
admet-291	1	76	author	author	NOUN
admet-291	1	77	:	:	PUNCT
admet-291	1	78	e	e	NOUN
admet-291	1	79	-	-	NOUN
admet-291	1	80	mail	mail	NOUN
admet-291	1	81	:	:	PUNCT
admet-291	1	82	deepika.sh25@yahoo.com	deepika.sh25@yahoo.com	X
admet-291	1	83	.	.	PROPN
admet-291	1	84	received	receive	VERB
admet-291	1	85	:	:	PUNCT
admet-291	1	86	march	march	PROPN
admet-291	1	87	25	25	NUM
admet-291	1	88	,	,	PUNCT
admet-291	1	89	2016	2016	NUM
admet-291	1	90	;	;	PUNCT
admet-291	1	91	revised	revise	VERB
admet-291	1	92	:	:	PUNCT
admet-291	1	93	may	may	AUX
admet-291	1	94	14	14	NUM
admet-291	1	95	,	,	PUNCT
admet-291	1	96	2016	2016	NUM
admet-291	1	97	;	;	PUNCT
admet-291	1	98	published	publish	VERB
admet-291	1	99	:	:	PUNCT
admet-291	1	100	june	june	PROPN
admet-291	1	101	29	29	NUM
admet-291	1	102	,	,	PUNCT
admet-291	1	103	2016	2016	NUM
admet-291	1	104	abstract	abstract	NOUN
admet-291	1	105	as	as	ADP
admet-291	1	106	part	part	NOUN
admet-291	1	107	of	of	ADP
admet-291	1	108	our	our	PRON
admet-291	1	109	endeavor	endeavor	NOUN
admet-291	1	110	to	to	PART
admet-291	1	111	enhance	enhance	VERB
admet-291	1	112	survival	survival	NOUN
admet-291	1	113	of	of	ADP
admet-291	1	114	natural	natural	ADJ
admet-291	1	115	product	product	NOUN
admet-291	1	116	derived	derive	VERB
admet-291	1	117	drug	drug	NOUN
admet-291	1	118	candidates	candidate	NOUN
admet-291	1	119	and	and	CCONJ
admet-291	1	120	to	to	PART
admet-291	1	121	guide	guide	VERB
admet-291	1	122	the	the	DET
admet-291	1	123	medicinal	medicinal	ADJ
admet-291	1	124	chemist	chemist	NOUN
admet-291	1	125	to	to	PART
admet-291	1	126	design	design	VERB
admet-291	1	127	higher	high	ADJ
admet-291	1	128	probability	probability	NOUN
admet-291	1	129	space	space	NOUN
admet-291	1	130	for	for	ADP
admet-291	1	131	success	success	NOUN
admet-291	1	132	in	in	ADP
admet-291	1	133	the	the	DET
admet-291	1	134	anti	anti	PROPN
admet-291	1	135	cancer	cancer	NOUN
admet-291	1	136	drug	drug	PROPN
admet-291	1	137	development	development	NOUN
admet-291	1	138	area	area	NOUN
admet-291	1	139	,	,	PUNCT
admet-291	1	140	we	we	PRON
admet-291	1	141	embarked	embark	VERB
admet-291	1	142	on	on	ADP
admet-291	1	143	a	a	DET
admet-291	1	144	detailed	detailed	ADJ
admet-291	1	145	study	study	NOUN
admet-291	1	146	of	of	ADP
admet-291	1	147	the	the	DET
admet-291	1	148	property	property	NOUN
admet-291	1	149	space	space	NOUN
admet-291	1	150	for	for	ADP
admet-291	1	151	a	a	DET
admet-291	1	152	collection	collection	NOUN
admet-291	1	153	of	of	ADP
admet-291	1	154	natural	natural	ADJ
admet-291	1	155	product	product	NOUN
admet-291	1	156	derived	derive	VERB
admet-291	1	157	anti	anti	ADJ
admet-291	1	158	cancer	cancer	NOUN
admet-291	1	159	molecules	molecule	NOUN
admet-291	1	160	.	.	PUNCT
admet-291	2	1	we	we	PRON
admet-291	2	2	carried	carry	VERB
admet-291	2	3	out	out	ADP
admet-291	2	4	a	a	DET
admet-291	2	5	comprehensive	comprehensive	ADJ
admet-291	2	6	analysis	analysis	NOUN
admet-291	2	7	of	of	ADP
admet-291	2	8	properties	property	NOUN
admet-291	2	9	for	for	ADP
admet-291	2	10	24	24	NUM
admet-291	2	11	natural	natural	ADJ
admet-291	2	12	products	product	NOUN
admet-291	2	13	derived	derive	VERB
admet-291	2	14	anti	anti	NOUN
admet-291	2	15	cancer	cancer	NOUN
admet-291	2	16	drugs	drug	NOUN
admet-291	2	17	including	include	VERB
admet-291	2	18	clinical	clinical	ADJ
admet-291	2	19	development	development	NOUN
admet-291	2	20	candidates	candidate	NOUN
admet-291	2	21	and	and	CCONJ
admet-291	2	22	a	a	DET
admet-291	2	23	set	set	NOUN
admet-291	2	24	of	of	ADP
admet-291	2	25	27	27	NUM
admet-291	2	26	natural	natural	ADJ
admet-291	2	27	products	product	NOUN
admet-291	2	28	derived	derive	VERB
admet-291	2	29	anti	anti	NOUN
admet-291	2	30	cancer	cancer	NOUN
admet-291	2	31	lead	lead	NOUN
admet-291	2	32	compounds	compound	NOUN
admet-291	2	33	.	.	PUNCT
admet-291	3	1	in	in	ADP
admet-291	3	2	particular	particular	ADJ
admet-291	3	3	,	,	PUNCT
admet-291	3	4	we	we	PRON
admet-291	3	5	focused	focus	VERB
admet-291	3	6	on	on	ADP
admet-291	3	7	understanding	understand	VERB
admet-291	3	8	the	the	DET
admet-291	3	9	interplay	interplay	NOUN
admet-291	3	10	among	among	ADP
admet-291	3	11	eight	eight	NUM
admet-291	3	12	physicochemical	physicochemical	ADJ
admet-291	3	13	properties	property	NOUN
admet-291	3	14	including	include	VERB
admet-291	3	15	like	like	ADP
admet-291	3	16	partition	partition	NOUN
admet-291	3	17	coefficient	coefficient	NOUN
admet-291	3	18	(	(	PUNCT
admet-291	3	19	log	log	VERB
admet-291	3	20	p	p	NOUN
admet-291	3	21	)	)	PUNCT
admet-291	3	22	,	,	PUNCT
admet-291	3	23	distribution	distribution	NOUN
admet-291	3	24	coefficient	coefficient	NOUN
admet-291	3	25	at	at	ADP
admet-291	3	26	ph=7.4	ph=7.4	PROPN
admet-291	3	27	(	(	PUNCT
admet-291	3	28	log	log	NOUN
admet-291	3	29	d	d	NOUN
admet-291	3	30	)	)	PUNCT
admet-291	3	31	,	,	PUNCT
admet-291	3	32	topological	topological	ADJ
admet-291	3	33	polar	polar	ADJ
admet-291	3	34	surface	surface	NOUN
admet-291	3	35	area	area	NOUN
admet-291	3	36	(	(	PUNCT
admet-291	3	37	tpsa	tpsa	PROPN
admet-291	3	38	)	)	PUNCT
admet-291	3	39	,	,	PUNCT
admet-291	3	40	molecular	molecular	ADJ
admet-291	3	41	weight	weight	NOUN
admet-291	3	42	(	(	PUNCT
admet-291	3	43	mw	mw	NOUN
admet-291	3	44	)	)	PUNCT
admet-291	3	45	,	,	PUNCT
admet-291	3	46	aqueous	aqueous	ADJ
admet-291	3	47	solubility	solubility	NOUN
admet-291	3	48	(	(	PUNCT
admet-291	3	49	log	log	NOUN
admet-291	3	50	s	s	PART
admet-291	3	51	)	)	PUNCT
admet-291	3	52	,	,	PUNCT
admet-291	3	53	number	number	NOUN
admet-291	3	54	of	of	ADP
admet-291	3	55	hydrogen	hydrogen	NOUN
admet-291	3	56	bond	bond	NOUN
admet-291	3	57	acceptors	acceptor	NOUN
admet-291	3	58	(	(	PUNCT
admet-291	3	59	hba	hba	NOUN
admet-291	3	60	)	)	PUNCT
admet-291	3	61	,	,	PUNCT
admet-291	3	62	number	number	NOUN
admet-291	3	63	of	of	ADP
admet-291	3	64	hydrogen	hydrogen	NOUN
admet-291	3	65	bond	bond	NOUN
admet-291	3	66	donors	donor	NOUN
admet-291	3	67	(	(	PUNCT
admet-291	3	68	hbd	hbd	NOUN
admet-291	3	69	)	)	PUNCT
admet-291	3	70	and	and	CCONJ
admet-291	3	71	number	number	NOUN
admet-291	3	72	of	of	ADP
admet-291	3	73	rotatable	rotatable	ADJ
admet-291	3	74	bonds	bond	NOUN
admet-291	3	75	(	(	PUNCT
admet-291	3	76	nrot	nrot	NOUN
admet-291	3	77	)	)	PUNCT
admet-291	3	78	crucial	crucial	ADJ
admet-291	3	79	for	for	ADP
admet-291	3	80	drug	drug	NOUN
admet-291	3	81	design	design	NOUN
admet-291	3	82	and	and	CCONJ
admet-291	3	83	relationships	relationship	NOUN
admet-291	3	84	between	between	ADP
admet-291	3	85	physicochemical	physicochemical	ADJ
admet-291	3	86	properties	property	NOUN
admet-291	3	87	,	,	PUNCT
admet-291	3	88	adme	adme	NOUN
admet-291	3	89	(	(	PUNCT
admet-291	3	90	absorption	absorption	NOUN
admet-291	3	91	,	,	PUNCT
admet-291	3	92	distribution	distribution	NOUN
admet-291	3	93	,	,	PUNCT
admet-291	3	94	metabolism	metabolism	NOUN
admet-291	3	95	,	,	PUNCT
admet-291	3	96	and	and	CCONJ
admet-291	3	97	elimination	elimination	NOUN
admet-291	3	98	)	)	PUNCT
admet-291	3	99	attributes	attribute	VERB
admet-291	3	100	,	,	PUNCT
admet-291	3	101	and	and	CCONJ
admet-291	3	102	in	in	ADP
admet-291	3	103	silico	silico	NOUN
admet-291	3	104	toxicity	toxicity	NOUN
admet-291	3	105	profile	profile	NOUN
admet-291	3	106	for	for	ADP
admet-291	3	107	these	these	DET
admet-291	3	108	two	two	NUM
admet-291	3	109	sets	set	NOUN
admet-291	3	110	of	of	ADP
admet-291	3	111	compounds	compound	NOUN
admet-291	3	112	.	.	PUNCT
admet-291	4	1	this	this	DET
admet-291	4	2	analysis	analysis	NOUN
admet-291	4	3	provides	provide	VERB
admet-291	4	4	guidance	guidance	NOUN
admet-291	4	5	for	for	SCONJ
admet-291	4	6	the	the	DET
admet-291	4	7	chemist	chemist	NOUN
admet-291	4	8	to	to	PART
admet-291	4	9	modify	modify	VERB
admet-291	4	10	the	the	DET
admet-291	4	11	existing	exist	VERB
admet-291	4	12	natural	natural	ADJ
admet-291	4	13	product	product	NOUN
admet-291	4	14	scaffold	scaffold	NOUN
admet-291	4	15	or	or	CCONJ
admet-291	4	16	designing	designing	NOUN
admet-291	4	17	of	of	ADP
admet-291	4	18	new	new	ADJ
admet-291	4	19	anti	anti	ADJ
admet-291	4	20	cancer	cancer	NOUN
admet-291	4	21	molecules	molecule	NOUN
admet-291	4	22	in	in	ADP
admet-291	4	23	a	a	DET
admet-291	4	24	property	property	NOUN
admet-291	4	25	space	space	NOUN
admet-291	4	26	with	with	ADP
admet-291	4	27	increased	increase	VERB
admet-291	4	28	probability	probability	NOUN
admet-291	4	29	of	of	ADP
admet-291	4	30	success	success	NOUN
admet-291	4	31	and	and	CCONJ
admet-291	4	32	may	may	AUX
admet-291	4	33	lead	lead	VERB
admet-291	4	34	to	to	ADP
admet-291	4	35	the	the	DET
admet-291	4	36	identification	identification	NOUN
admet-291	4	37	of	of	ADP
admet-291	4	38	druglike	druglike	ADJ
admet-291	4	39	candidates	candidate	NOUN
admet-291	4	40	with	with	ADP
admet-291	4	41	favorable	favorable	ADJ
admet-291	4	42	safety	safety	NOUN
admet-291	4	43	profiles	profile	NOUN
admet-291	4	44	that	that	PRON
admet-291	4	45	can	can	AUX
admet-291	4	46	successfully	successfully	ADV
admet-291	4	47	test	test	VERB
admet-291	4	48	hypotheses	hypothesis	NOUN
admet-291	4	49	in	in	ADP
admet-291	4	50	the	the	DET
admet-291	4	51	clinic	clinic	NOUN
admet-291	4	52	.	.	PUNCT
admet-291	5	1	keywords	keyword	NOUN
admet-291	5	2	anticancer	anticancer	NOUN
admet-291	5	3	,	,	PUNCT
admet-291	5	4	admet	admet	ADJ
admet-291	5	5	,	,	PUNCT
admet-291	5	6	natural	natural	ADJ
admet-291	5	7	products	product	NOUN
admet-291	5	8	,	,	PUNCT
admet-291	5	9	physicochemical	physicochemical	ADJ
admet-291	5	10	property	property	NOUN
admet-291	5	11	,	,	PUNCT
admet-291	5	12	pharmacokinetic	pharmacokinetic	ADJ
admet-291	5	13	-	-	PUNCT
admet-291	5	14	pharmacodynamic	pharmacodynamic	ADJ
admet-291	5	15	introduction	introduction	NOUN
admet-291	5	16	cancer	cancer	NOUN
admet-291	5	17	is	be	AUX
admet-291	5	18	one	one	NUM
admet-291	5	19	of	of	ADP
admet-291	5	20	the	the	DET
admet-291	5	21	major	major	ADJ
admet-291	5	22	disease	disease	NOUN
admet-291	5	23	causes	cause	NOUN
admet-291	5	24	of	of	ADP
admet-291	5	25	mortality	mortality	NOUN
admet-291	5	26	worldwide	worldwide	ADV
admet-291	5	27	and	and	CCONJ
admet-291	5	28	the	the	DET
admet-291	5	29	numbers	number	NOUN
admet-291	5	30	of	of	ADP
admet-291	5	31	cancer	cancer	NOUN
admet-291	5	32	cases	case	NOUN
admet-291	5	33	are	be	AUX
admet-291	5	34	increasing	increase	VERB
admet-291	5	35	gradually	gradually	ADV
admet-291	5	36	[	[	X
admet-291	5	37	1	1	NUM
admet-291	5	38	]	]	PUNCT
admet-291	5	39	.	.	PUNCT
admet-291	6	1	cancer	cancer	NOUN
admet-291	6	2	is	be	AUX
admet-291	6	3	a	a	DET
admet-291	6	4	main	main	ADJ
admet-291	6	5	public	public	ADJ
admet-291	6	6	health	health	NOUN
admet-291	6	7	burden	burden	NOUN
admet-291	6	8	in	in	ADP
admet-291	6	9	both	both	CCONJ
admet-291	6	10	developed	developed	ADJ
admet-291	6	11	and	and	CCONJ
admet-291	6	12	developing	develop	VERB
admet-291	6	13	countries	country	NOUN
admet-291	6	14	and	and	CCONJ
admet-291	6	15	affects	affect	VERB
admet-291	6	16	the	the	DET
admet-291	6	17	lives	life	NOUN
admet-291	6	18	of	of	ADP
admet-291	6	19	millions	million	NOUN
admet-291	6	20	of	of	ADP
admet-291	6	21	people	people	NOUN
admet-291	6	22	.	.	PUNCT
admet-291	7	1	cancer	cancer	NOUN
admet-291	7	2	is	be	AUX
admet-291	7	3	an	an	DET
admet-291	7	4	abnormal	abnormal	ADJ
admet-291	7	5	growth	growth	NOUN
admet-291	7	6	of	of	ADP
admet-291	7	7	cells	cell	NOUN
admet-291	7	8	in	in	ADP
admet-291	7	9	the	the	DET
admet-291	7	10	body	body	NOUN
admet-291	7	11	,	,	PUNCT
admet-291	7	12	which	which	PRON
admet-291	7	13	underlies	underlie	VERB
admet-291	7	14	a	a	DET
admet-291	7	15	collection	collection	NOUN
admet-291	7	16	of	of	ADP
admet-291	7	17	multiple	multiple	ADJ
admet-291	7	18	genetic	genetic	ADJ
admet-291	7	19	abnormalities	abnormality	NOUN
admet-291	7	20	through	through	ADP
admet-291	7	21	a	a	DET
admet-291	7	22	multistep	multistep	ADJ
admet-291	7	23	,	,	PUNCT
admet-291	7	24	mutagenic	mutagenic	ADJ
admet-291	7	25	process	process	NOUN
admet-291	7	26	.	.	PUNCT
admet-291	8	1	cancer	cancer	NOUN
admet-291	8	2	cells	cell	NOUN
admet-291	8	3	usually	usually	ADV
admet-291	8	4	invade	invade	VERB
admet-291	8	5	and	and	CCONJ
admet-291	8	6	destroy	destroy	VERB
admet-291	8	7	normal	normal	ADJ
admet-291	8	8	cells	cell	NOUN
admet-291	8	9	in	in	ADP
admet-291	8	10	the	the	DET
admet-291	8	11	body	body	NOUN
admet-291	8	12	.	.	PUNCT
admet-291	9	1	factors	factor	NOUN
admet-291	9	2	responsible	responsible	ADJ
admet-291	9	3	for	for	ADP
admet-291	9	4	cancers	cancer	NOUN
admet-291	9	5	includes	include	VERB
admet-291	9	6	genetic	genetic	ADJ
admet-291	9	7	predisposition	predisposition	NOUN
admet-291	9	8	,	,	PUNCT
admet-291	9	9	smoking	smoking	NOUN
admet-291	9	10	,	,	PUNCT
admet-291	9	11	incorrect	incorrect	ADJ
admet-291	9	12	diet	diet	NOUN
admet-291	9	13	,	,	PUNCT
admet-291	9	14	infectious	infectious	ADJ
admet-291	9	15	diseases	disease	NOUN
admet-291	9	16	and	and	CCONJ
admet-291	9	17	environmental	environmental	ADJ
admet-291	9	18	factors	factor	NOUN
admet-291	9	19	.	.	PUNCT
admet-291	10	1	american	american	ADJ
admet-291	10	2	cancer	cancer	NOUN
admet-291	10	3	society	society	PROPN
admet-291	10	4	has	have	AUX
admet-291	10	5	predicted	predict	VERB
admet-291	10	6	~27	~27	PUNCT
admet-291	10	7	million	million	NUM
admet-291	10	8	newly	newly	ADV
admet-291	10	9	diagnosed	diagnose	VERB
admet-291	10	10	individuals	individual	NOUN
admet-291	10	11	and	and	CCONJ
admet-291	10	12	~17	~17	NOUN
admet-291	10	13	million	million	NUM
admet-291	10	14	cancer	cancer	NOUN
admet-291	10	15	related	relate	VERB
admet-291	10	16	deaths	death	NOUN
admet-291	10	17	globally	globally	ADV
admet-291	10	18	by	by	ADP
admet-291	10	19	2050	2050	NUM
admet-291	11	1	[	[	X
admet-291	11	2	2	2	NUM
admet-291	11	3	]	]	PUNCT
admet-291	11	4	.	.	PUNCT
admet-291	12	1	the	the	DET
admet-291	12	2	key	key	ADJ
admet-291	12	3	problem	problem	NOUN
admet-291	12	4	to	to	ADP
admet-291	12	5	cancer	cancer	NOUN
admet-291	12	6	treatment	treatment	NOUN
admet-291	12	7	is	be	AUX
admet-291	12	8	the	the	DET
admet-291	12	9	recurrence	recurrence	NOUN
admet-291	12	10	of	of	ADP
admet-291	12	11	tumor	tumor	NOUN
admet-291	12	12	and	and	CCONJ
admet-291	12	13	the	the	DET
admet-291	12	14	side	side	NOUN
admet-291	12	15	effects	effect	NOUN
admet-291	12	16	of	of	ADP
admet-291	12	17	chemotherapy	chemotherapy	NOUN
admet-291	12	18	drugs	drug	NOUN
admet-291	12	19	.	.	PUNCT
admet-291	13	1	hence	hence	ADV
admet-291	13	2	,	,	PUNCT
admet-291	13	3	there	there	PRON
admet-291	13	4	is	be	VERB
admet-291	13	5	a	a	DET
admet-291	13	6	potential	potential	ADJ
admet-291	13	7	demand	demand	NOUN
admet-291	13	8	to	to	PART
admet-291	13	9	develop	develop	VERB
admet-291	13	10	new	new	ADJ
admet-291	13	11	and	and	CCONJ
admet-291	13	12	efficient	efficient	ADJ
admet-291	13	13	anti	anti	ADJ
admet-291	13	14	-	-	ADJ
admet-291	13	15	cancer	cancer	ADJ
admet-291	13	16	drugs	drug	NOUN
admet-291	13	17	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-291	13	18	mailto:deepika.sh25@yahoo.com	mailto:deepika.sh25@yahoo.com	PROPN
admet-291	13	19	admet	admet	PROPN
admet-291	13	20	&	&	CCONJ
admet-291	13	21	dmpk	dmpk	PROPN
admet-291	13	22	4(2	4(2	NUM
admet-291	13	23	)	)	PUNCT
admet-291	13	24	(	(	PUNCT
admet-291	13	25	2016	2016	NUM
admet-291	13	26	)	)	PUNCT
admet-291	13	27	98	98	NUM
admet-291	13	28	-	-	SYM
admet-291	13	29	113	113	NUM
admet-291	13	30	defining	define	VERB
admet-291	13	31	natural	natural	ADJ
admet-291	13	32	product	product	NOUN
admet-291	13	33	derived	derive	VERB
admet-291	13	34	anticancer	anticancer	NOUN
admet-291	13	35	drug	drug	NOUN
admet-291	13	36	space	space	NOUN
admet-291	13	37	doi	doi	NOUN
admet-291	13	38	:	:	PUNCT
admet-291	13	39	10.5599	10.5599	NUM
admet-291	13	40	/	/	SYM
admet-291	13	41	admet.4.2.291	admet.4.2.291	PROPN
admet-291	13	42	99	99	NUM
admet-291	14	1	[	[	X
admet-291	14	2	3	3	NUM
admet-291	14	3	]	]	PUNCT
admet-291	14	4	.	.	PUNCT
admet-291	15	1	natural	natural	ADJ
admet-291	15	2	products	product	NOUN
admet-291	15	3	have	have	AUX
admet-291	15	4	received	receive	VERB
admet-291	15	5	increasing	increase	VERB
admet-291	15	6	attention	attention	NOUN
admet-291	15	7	in	in	ADP
admet-291	15	8	the	the	DET
admet-291	15	9	past	past	ADJ
admet-291	15	10	30	30	NUM
admet-291	15	11	years	year	NOUN
admet-291	15	12	for	for	ADP
admet-291	15	13	the	the	DET
admet-291	15	14	discovery	discovery	NOUN
admet-291	15	15	of	of	ADP
admet-291	15	16	novel	novel	ADJ
admet-291	15	17	cancer	cancer	NOUN
admet-291	15	18	preventive	preventive	ADJ
admet-291	15	19	and	and	CCONJ
admet-291	15	20	therapeutic	therapeutic	ADJ
admet-291	15	21	agents	agent	NOUN
admet-291	15	22	[	[	X
admet-291	15	23	4	4	NUM
admet-291	15	24	]	]	PUNCT
admet-291	15	25	.	.	PUNCT
admet-291	16	1	natural	natural	ADJ
admet-291	16	2	products	product	NOUN
admet-291	16	3	have	have	AUX
admet-291	16	4	been	be	AUX
admet-291	16	5	used	use	VERB
admet-291	16	6	for	for	ADP
admet-291	16	7	centuries	century	NOUN
admet-291	16	8	for	for	ADP
admet-291	16	9	the	the	DET
admet-291	16	10	treatment	treatment	NOUN
admet-291	16	11	of	of	ADP
admet-291	16	12	several	several	ADJ
admet-291	16	13	ailments	ailment	NOUN
admet-291	16	14	.	.	PUNCT
admet-291	17	1	there	there	PRON
admet-291	17	2	are	be	VERB
admet-291	17	3	many	many	ADJ
admet-291	17	4	basic	basic	ADJ
admet-291	17	5	ancient	ancient	ADJ
admet-291	17	6	medicinal	medicinal	ADJ
admet-291	17	7	systems	system	NOUN
admet-291	17	8	derived	derive	VERB
admet-291	17	9	from	from	ADP
admet-291	17	10	dietary	dietary	ADJ
admet-291	17	11	sources	source	NOUN
admet-291	17	12	.	.	PUNCT
admet-291	18	1	nature	nature	NOUN
admet-291	18	2	has	have	AUX
admet-291	18	3	provided	provide	VERB
admet-291	18	4	a	a	DET
admet-291	18	5	plenty	plenty	NOUN
admet-291	18	6	of	of	ADP
admet-291	18	7	natural	natural	ADJ
admet-291	18	8	products	product	NOUN
admet-291	18	9	with	with	ADP
admet-291	18	10	potential	potential	ADJ
admet-291	18	11	anti	anti	ADJ
admet-291	18	12	-	-	ADJ
admet-291	18	13	cancer	cancer	ADJ
admet-291	18	14	activity	activity	NOUN
admet-291	18	15	in	in	ADP
admet-291	18	16	the	the	DET
admet-291	18	17	last	last	ADJ
admet-291	18	18	few	few	ADJ
admet-291	18	19	decades	decade	NOUN
admet-291	18	20	.	.	PUNCT
admet-291	19	1	since	since	SCONJ
admet-291	19	2	1940	1940	NUM
admet-291	19	3	,	,	PUNCT
admet-291	19	4	approximately	approximately	ADV
admet-291	19	5	175	175	NUM
admet-291	19	6	small	small	ADJ
admet-291	19	7	molecules	molecule	NOUN
admet-291	19	8	have	have	AUX
admet-291	19	9	been	be	AUX
admet-291	19	10	approved	approve	VERB
admet-291	19	11	as	as	ADP
admet-291	19	12	anti	anti	ADJ
admet-291	19	13	-	-	ADJ
admet-291	19	14	cancer	cancer	ADJ
admet-291	19	15	agents	agent	NOUN
admet-291	19	16	,	,	PUNCT
admet-291	19	17	of	of	ADP
admet-291	19	18	these	these	PRON
admet-291	19	19	,	,	PUNCT
admet-291	19	20	48.6	48.6	NUM
admet-291	19	21	%	%	NOUN
admet-291	19	22	were	be	AUX
admet-291	19	23	a	a	DET
admet-291	19	24	natural	natural	ADJ
admet-291	19	25	product	product	NOUN
admet-291	19	26	or	or	CCONJ
admet-291	19	27	derivative	derivative	NOUN
admet-291	19	28	[	[	X
admet-291	19	29	5	5	NUM
admet-291	19	30	]	]	PUNCT
admet-291	19	31	.	.	PUNCT
admet-291	20	1	currently	currently	ADV
admet-291	20	2	,	,	PUNCT
admet-291	20	3	pharmaceutical	pharmaceutical	ADJ
admet-291	20	4	industry	industry	NOUN
admet-291	20	5	faces	face	VERB
admet-291	20	6	large	large	ADJ
admet-291	20	7	attrition	attrition	NOUN
admet-291	20	8	rates	rate	NOUN
admet-291	20	9	of	of	ADP
admet-291	20	10	preclinical	preclinical	ADJ
admet-291	20	11	and	and	CCONJ
admet-291	20	12	clinical	clinical	ADJ
admet-291	20	13	candidates	candidate	NOUN
admet-291	20	14	due	due	ADP
admet-291	20	15	to	to	ADP
admet-291	20	16	toxicity	toxicity	NOUN
admet-291	20	17	or	or	CCONJ
admet-291	20	18	lag	lag	NOUN
admet-291	20	19	of	of	ADP
admet-291	20	20	optimal	optimal	ADJ
admet-291	20	21	pharmacokinetics	pharmacokinetic	NOUN
admet-291	20	22	properties	property	NOUN
admet-291	20	23	,	,	PUNCT
admet-291	20	24	resulting	result	VERB
admet-291	20	25	in	in	ADP
admet-291	20	26	high	high	ADJ
admet-291	20	27	costs	cost	NOUN
admet-291	20	28	and	and	CCONJ
admet-291	20	29	increased	increase	VERB
admet-291	20	30	timelines	timeline	NOUN
admet-291	20	31	for	for	ADP
admet-291	20	32	the	the	DET
admet-291	20	33	drug	drug	NOUN
admet-291	20	34	discovery	discovery	NOUN
admet-291	20	35	process	process	NOUN
admet-291	20	36	[	[	X
admet-291	20	37	6	6	NUM
admet-291	20	38	]	]	PUNCT
admet-291	20	39	.	.	PUNCT
admet-291	21	1	lead	lead	NOUN
admet-291	21	2	structures	structure	NOUN
admet-291	21	3	are	be	AUX
admet-291	21	4	compounds	compound	NOUN
admet-291	21	5	that	that	PRON
admet-291	21	6	typically	typically	ADV
admet-291	21	7	exhibit	exhibit	VERB
admet-291	21	8	suboptimal	suboptimal	ADJ
admet-291	21	9	target	target	NOUN
admet-291	21	10	binding	bind	VERB
admet-291	21	11	affinity	affinity	NOUN
admet-291	21	12	.	.	PUNCT
admet-291	22	1	pharmacological	pharmacological	ADJ
admet-291	22	2	studies	study	NOUN
admet-291	22	3	have	have	AUX
admet-291	22	4	shown	show	VERB
admet-291	22	5	that	that	SCONJ
admet-291	22	6	there	there	PRON
admet-291	22	7	is	be	VERB
admet-291	22	8	a	a	DET
admet-291	22	9	difference	difference	NOUN
admet-291	22	10	exists	exist	VERB
admet-291	22	11	between	between	ADP
admet-291	22	12	leads	lead	NOUN
admet-291	22	13	and	and	CCONJ
admet-291	22	14	drugs	drug	NOUN
admet-291	22	15	[	[	X
admet-291	22	16	7	7	NUM
admet-291	22	17	]	]	PUNCT
admet-291	22	18	.	.	PUNCT
admet-291	23	1	the	the	DET
admet-291	23	2	present	present	ADJ
admet-291	23	3	study	study	NOUN
admet-291	23	4	is	be	AUX
admet-291	23	5	an	an	DET
admet-291	23	6	approach	approach	NOUN
admet-291	23	7	to	to	PART
admet-291	23	8	establish	establish	VERB
admet-291	23	9	the	the	DET
admet-291	23	10	difference	difference	NOUN
admet-291	23	11	between	between	ADP
admet-291	23	12	some	some	DET
admet-291	23	13	selected	select	VERB
admet-291	23	14	potent	potent	ADJ
admet-291	23	15	anticancer	anticancer	NOUN
admet-291	23	16	natural	natural	ADJ
admet-291	23	17	compounds	compound	NOUN
admet-291	23	18	(	(	PUNCT
admet-291	23	19	leads	lead	NOUN
admet-291	23	20	)	)	PUNCT
admet-291	23	21	and	and	CCONJ
admet-291	23	22	fda	fda	PROPN
admet-291	23	23	approved	approve	VERB
admet-291	23	24	natural	natural	ADJ
admet-291	23	25	product	product	NOUN
admet-291	23	26	derived	derive	VERB
admet-291	23	27	anti	anti	NOUN
admet-291	23	28	cancer	cancer	NOUN
admet-291	23	29	drugs	drug	NOUN
admet-291	23	30	considering	consider	VERB
admet-291	23	31	the	the	DET
admet-291	23	32	distribution	distribution	NOUN
admet-291	23	33	of	of	ADP
admet-291	23	34	physicochemical	physicochemical	ADJ
admet-291	23	35	,	,	PUNCT
admet-291	23	36	adme	adme	NOUN
admet-291	23	37	(	(	PUNCT
admet-291	23	38	absorption	absorption	NOUN
admet-291	23	39	,	,	PUNCT
admet-291	23	40	distribution	distribution	NOUN
admet-291	23	41	,	,	PUNCT
admet-291	23	42	metabolism	metabolism	NOUN
admet-291	23	43	,	,	PUNCT
admet-291	23	44	and	and	CCONJ
admet-291	23	45	elimination	elimination	NOUN
admet-291	23	46	)	)	PUNCT
admet-291	23	47	attributes	attribute	NOUN
admet-291	23	48	and	and	CCONJ
admet-291	23	49	in	in	ADP
admet-291	23	50	silico	silico	NOUN
admet-291	23	51	toxicity	toxicity	NOUN
admet-291	23	52	endpoints	endpoint	NOUN
admet-291	23	53	.	.	PUNCT
admet-291	24	1	this	this	DET
admet-291	24	2	data	datum	NOUN
admet-291	24	3	was	be	AUX
admet-291	24	4	examined	examine	VERB
admet-291	24	5	with	with	ADP
admet-291	24	6	the	the	DET
admet-291	24	7	goal	goal	NOUN
admet-291	24	8	of	of	ADP
admet-291	24	9	identifying	identify	VERB
admet-291	24	10	trends	trend	NOUN
admet-291	24	11	and	and	CCONJ
admet-291	24	12	defining	define	VERB
admet-291	24	13	a	a	DET
admet-291	24	14	set	set	NOUN
admet-291	24	15	of	of	ADP
admet-291	24	16	property	property	NOUN
admet-291	24	17	values	value	NOUN
admet-291	24	18	that	that	PRON
admet-291	24	19	would	would	AUX
admet-291	24	20	best	well	ADV
admet-291	24	21	define	define	VERB
admet-291	24	22	the	the	DET
admet-291	24	23	anticancer	anticancer	NOUN
admet-291	24	24	drug	drug	NOUN
admet-291	24	25	space	space	NOUN
admet-291	24	26	associated	associate	VERB
admet-291	24	27	with	with	ADP
admet-291	24	28	a	a	DET
admet-291	24	29	higher	high	ADJ
admet-291	24	30	probability	probability	NOUN
admet-291	24	31	of	of	ADP
admet-291	24	32	clinical	clinical	ADJ
admet-291	24	33	success	success	NOUN
admet-291	24	34	.	.	PUNCT
admet-291	25	1	several	several	ADJ
admet-291	25	2	critical	critical	ADJ
admet-291	25	3	physicochemical	physicochemical	ADJ
admet-291	25	4	properties	property	NOUN
admet-291	25	5	of	of	ADP
admet-291	25	6	compounds	compound	NOUN
admet-291	25	7	like	like	ADP
admet-291	25	8	log	log	NOUN
admet-291	25	9	p	p	NOUN
admet-291	25	10	,	,	PUNCT
admet-291	25	11	log	log	NOUN
admet-291	25	12	d	d	NOUN
admet-291	25	13	,	,	PUNCT
admet-291	25	14	tpsa	tpsa	PROPN
admet-291	25	15	,	,	PUNCT
admet-291	25	16	mw	mw	X
admet-291	25	17	,	,	PUNCT
admet-291	25	18	log	log	NOUN
admet-291	25	19	s	s	PART
admet-291	25	20	,	,	PUNCT
admet-291	25	21	hba	hba	NOUN
admet-291	25	22	,	,	PUNCT
admet-291	25	23	hbd	hbd	NOUN
admet-291	25	24	and	and	CCONJ
admet-291	25	25	nrot	nrot	PROPN
admet-291	25	26	proposed	propose	VERB
admet-291	25	27	by	by	ADP
admet-291	25	28	various	various	ADJ
admet-291	25	29	research	research	NOUN
admet-291	25	30	groups	group	NOUN
admet-291	25	31	should	should	AUX
admet-291	25	32	be	be	AUX
admet-291	25	33	considered	consider	VERB
admet-291	25	34	for	for	ADP
admet-291	25	35	compounds	compound	NOUN
admet-291	25	36	with	with	ADP
admet-291	25	37	oral	oral	ADJ
admet-291	25	38	drug	drug	NOUN
admet-291	25	39	delivery	delivery	NOUN
admet-291	25	40	as	as	ADP
admet-291	25	41	a	a	DET
admet-291	25	42	concern	concern	NOUN
admet-291	25	43	[	[	X
admet-291	25	44	8	8	NUM
admet-291	25	45	]	]	PUNCT
admet-291	25	46	.	.	PUNCT
admet-291	26	1	the	the	DET
admet-291	26	2	information	information	NOUN
admet-291	26	3	obtained	obtain	VERB
admet-291	26	4	from	from	ADP
admet-291	26	5	this	this	DET
admet-291	26	6	analysis	analysis	NOUN
admet-291	26	7	could	could	AUX
admet-291	26	8	,	,	PUNCT
admet-291	26	9	in	in	ADP
admet-291	26	10	turn	turn	NOUN
admet-291	26	11	,	,	PUNCT
admet-291	26	12	be	be	AUX
admet-291	26	13	utilized	utilize	VERB
admet-291	26	14	to	to	PART
admet-291	26	15	design	design	VERB
admet-291	26	16	anticancer	anticancer	NOUN
admet-291	26	17	drug	drug	NOUN
admet-291	26	18	molecules	molecule	NOUN
admet-291	26	19	with	with	ADP
admet-291	26	20	optimum	optimum	ADJ
admet-291	26	21	bioavailability	bioavailability	NOUN
admet-291	26	22	and	and	CCONJ
admet-291	26	23	less	less	ADJ
admet-291	26	24	or	or	CCONJ
admet-291	26	25	no	no	PRON
admet-291	26	26	toxicity	toxicity	NOUN
admet-291	26	27	based	base	VERB
admet-291	26	28	on	on	ADP
admet-291	26	29	the	the	DET
admet-291	26	30	alignment	alignment	NOUN
admet-291	26	31	of	of	ADP
admet-291	26	32	a	a	DET
admet-291	26	33	set	set	NOUN
admet-291	26	34	of	of	ADP
admet-291	26	35	key	key	ADJ
admet-291	26	36	properties	property	NOUN
admet-291	26	37	.	.	PUNCT
admet-291	27	1	the	the	DET
admet-291	27	2	multi	multi	ADJ
admet-291	27	3	-	-	ADJ
admet-291	27	4	parameter	parameter	ADJ
admet-291	27	5	optimization	optimization	NOUN
admet-291	27	6	(	(	PUNCT
admet-291	27	7	mpo	mpo	PROPN
admet-291	27	8	)	)	PUNCT
admet-291	27	9	approach	approach	NOUN
admet-291	27	10	is	be	AUX
admet-291	27	11	very	very	ADV
admet-291	27	12	popular	popular	ADJ
admet-291	27	13	for	for	ADP
admet-291	27	14	providing	provide	VERB
admet-291	27	15	guidance	guidance	NOUN
admet-291	27	16	on	on	ADP
admet-291	27	17	how	how	SCONJ
admet-291	27	18	to	to	PART
admet-291	27	19	design	design	VERB
admet-291	27	20	preferred	preferred	ADJ
admet-291	27	21	molecules	molecule	NOUN
admet-291	27	22	to	to	PART
admet-291	27	23	reduce	reduce	VERB
admet-291	27	24	the	the	DET
admet-291	27	25	attrition	attrition	NOUN
admet-291	27	26	rate	rate	NOUN
admet-291	27	27	and	and	CCONJ
admet-291	27	28	increase	increase	VERB
admet-291	27	29	the	the	DET
admet-291	27	30	probability	probability	NOUN
admet-291	27	31	of	of	ADP
admet-291	27	32	prospectively	prospectively	ADV
admet-291	27	33	designing	design	VERB
admet-291	27	34	molecules	molecule	NOUN
admet-291	27	35	that	that	PRON
admet-291	27	36	survive	survive	VERB
admet-291	27	37	preclinical	preclinical	ADJ
admet-291	27	38	safety	safety	NOUN
admet-291	27	39	studies	study	NOUN
admet-291	27	40	and	and	CCONJ
admet-291	27	41	that	that	PRON
admet-291	27	42	possess	possess	VERB
admet-291	27	43	optimal	optimal	ADJ
admet-291	27	44	pharmacokinetic	pharmacokinetic	ADJ
admet-291	27	45	and	and	CCONJ
admet-291	27	46	pharmacodynamic	pharmacodynamic	ADJ
admet-291	27	47	properties	property	NOUN
admet-291	27	48	to	to	PART
admet-291	27	49	test	test	VERB
admet-291	27	50	hypotheses	hypothesis	NOUN
admet-291	27	51	in	in	ADP
admet-291	27	52	the	the	DET
admet-291	27	53	clinic	clinic	NOUN
admet-291	27	54	[	[	X
admet-291	27	55	9	9	NUM
admet-291	27	56	]	]	PUNCT
admet-291	27	57	.	.	PUNCT
admet-291	28	1	tremendous	tremendous	ADJ
admet-291	28	2	progress	progress	NOUN
admet-291	28	3	has	have	AUX
admet-291	28	4	been	be	AUX
admet-291	28	5	made	make	VERB
admet-291	28	6	in	in	ADP
admet-291	28	7	recent	recent	ADJ
admet-291	28	8	years	year	NOUN
admet-291	28	9	in	in	ADP
admet-291	28	10	terms	term	NOUN
admet-291	28	11	of	of	ADP
admet-291	28	12	enabling	enable	VERB
admet-291	28	13	the	the	DET
admet-291	28	14	development	development	NOUN
admet-291	28	15	of	of	ADP
admet-291	28	16	robust	robust	ADJ
admet-291	28	17	pharmacokineticpharmacodynamic	pharmacokineticpharmacodynamic	ADJ
admet-291	28	18	(	(	PUNCT
admet-291	28	19	pk	pk	NOUN
admet-291	28	20	/	/	SYM
admet-291	28	21	pd	pd	NOUN
admet-291	28	22	)	)	PUNCT
admet-291	28	23	relationships	relationship	NOUN
admet-291	28	24	for	for	ADP
admet-291	28	25	anticancer	anticancer	NOUN
admet-291	28	26	agents	agent	NOUN
admet-291	28	27	as	as	ADV
admet-291	28	28	well	well	ADV
admet-291	28	29	as	as	ADP
admet-291	28	30	in	in	ADP
admet-291	28	31	understanding	understanding	NOUN
admet-291	28	32	how	how	SCONJ
admet-291	28	33	these	these	DET
admet-291	28	34	relationships	relationship	NOUN
admet-291	28	35	are	be	AUX
admet-291	28	36	influenced	influence	VERB
admet-291	28	37	by	by	ADP
admet-291	28	38	molecular	molecular	ADJ
admet-291	28	39	physicochemical	physicochemical	ADJ
admet-291	28	40	properties	property	NOUN
admet-291	28	41	.	.	PUNCT
admet-291	29	1	key	key	ADJ
admet-291	29	2	physicochemical	physicochemical	ADJ
admet-291	29	3	properties	property	NOUN
admet-291	29	4	related	relate	VERB
admet-291	29	5	to	to	ADP
admet-291	29	6	a	a	DET
admet-291	29	7	drug	drug	NOUN
admet-291	29	8	like	like	ADP
admet-291	29	9	molecules	molecule	NOUN
admet-291	29	10	have	have	AUX
admet-291	29	11	been	be	AUX
admet-291	29	12	described	describe	VERB
admet-291	29	13	previously	previously	ADV
admet-291	29	14	by	by	ADP
admet-291	29	15	various	various	ADJ
admet-291	29	16	research	research	NOUN
admet-291	29	17	groups	group	NOUN
admet-291	29	18	[	[	X
admet-291	29	19	10	10	NUM
admet-291	29	20	]	]	PUNCT
admet-291	29	21	.	.	PUNCT
admet-291	30	1	the	the	DET
admet-291	30	2	most	most	ADV
admet-291	30	3	important	important	ADJ
admet-291	30	4	and	and	CCONJ
admet-291	30	5	well	well	ADV
admet-291	30	6	-	-	PUNCT
admet-291	30	7	known	know	VERB
admet-291	30	8	rule	rule	NOUN
admet-291	30	9	of	of	ADP
admet-291	30	10	five	five	NUM
admet-291	30	11	(	(	PUNCT
admet-291	30	12	ro5	ro5	NOUN
admet-291	30	13	)	)	PUNCT
admet-291	30	14	was	be	AUX
admet-291	30	15	given	give	VERB
admet-291	30	16	by	by	ADP
admet-291	30	17	lipinski	lipinski	PROPN
admet-291	30	18	et	et	PROPN
admet-291	30	19	al	al	PROPN
admet-291	30	20	.	.	PROPN
admet-291	31	1	in	in	ADP
admet-291	31	2	1997	1997	NUM
admet-291	31	3	based	base	VERB
admet-291	31	4	on	on	ADP
admet-291	31	5	the	the	DET
admet-291	31	6	database	database	NOUN
admet-291	31	7	of	of	ADP
admet-291	31	8	clinical	clinical	ADJ
admet-291	31	9	candidates	candidate	NOUN
admet-291	31	10	that	that	PRON
admet-291	31	11	had	have	AUX
admet-291	31	12	reached	reach	VERB
admet-291	31	13	phase	phase	NOUN
admet-291	31	14	ii	ii	NOUN
admet-291	31	15	trials	trial	NOUN
admet-291	31	16	or	or	CCONJ
admet-291	31	17	further	far	ADV
admet-291	31	18	[	[	X
admet-291	31	19	11	11	NUM
admet-291	31	20	]	]	PUNCT
admet-291	31	21	.	.	PUNCT
admet-291	32	1	ro5	ro5	ADJ
admet-291	32	2	provided	provide	VERB
admet-291	32	3	the	the	DET
admet-291	32	4	end	end	NOUN
admet-291	32	5	points	point	NOUN
admet-291	32	6	for	for	ADP
admet-291	32	7	four	four	NUM
admet-291	32	8	crucial	crucial	ADJ
admet-291	32	9	physicochemical	physicochemical	ADJ
admet-291	32	10	properties	property	NOUN
admet-291	32	11	that	that	PRON
admet-291	32	12	described	describe	VERB
admet-291	32	13	90	90	NUM
admet-291	32	14	%	%	NOUN
admet-291	32	15	of	of	ADP
admet-291	32	16	orally	orally	ADV
admet-291	32	17	active	active	ADJ
admet-291	32	18	drugs	drug	NOUN
admet-291	32	19	:	:	PUNCT
admet-291	32	20	(	(	PUNCT
admet-291	32	21	a	a	X
admet-291	32	22	)	)	PUNCT
admet-291	32	23	molecular	molecular	ADJ
admet-291	32	24	weight	weight	NOUN
admet-291	32	25	,	,	PUNCT
admet-291	32	26	mw	mw	X
admet-291	32	27	<	<	X
admet-291	32	28	500	500	NUM
admet-291	32	29	da	da	NOUN
admet-291	32	30	;	;	PUNCT
admet-291	32	31	(	(	PUNCT
admet-291	32	32	b	b	X
admet-291	32	33	)	)	PUNCT
admet-291	32	34	calculate	calculate	NOUN
admet-291	32	35	of	of	ADP
admet-291	32	36	1	1	NUM
admet-291	32	37	-	-	PUNCT
admet-291	32	38	octanol	octanol	NOUN
admet-291	32	39	/	/	SYM
admet-291	32	40	water	water	NOUN
admet-291	32	41	partition	partition	NOUN
admet-291	32	42	coefficient	coefficient	NOUN
admet-291	32	43	,	,	PUNCT
admet-291	32	44	clogp	clogp	VERB
admet-291	32	45	<	<	X
admet-291	32	46	5	5	NUM
admet-291	32	47	;	;	PUNCT
admet-291	32	48	(	(	PUNCT
admet-291	32	49	c	c	X
admet-291	32	50	)	)	PUNCT
admet-291	32	51	number	number	NOUN
admet-291	32	52	of	of	ADP
admet-291	32	53	hydrogenbond	hydrogenbond	ADJ
admet-291	32	54	donors	donor	NOUN
admet-291	32	55	,	,	PUNCT
admet-291	32	56	(	(	PUNCT
admet-291	32	57	oh	oh	INTJ
admet-291	32	58	plus	plus	CCONJ
admet-291	32	59	nh	nh	PROPN
admet-291	32	60	count	count	NOUN
admet-291	32	61	)	)	PUNCT
admet-291	32	62	<	<	X
admet-291	32	63	5	5	NUM
admet-291	32	64	;	;	PUNCT
admet-291	32	65	and	and	CCONJ
admet-291	32	66	(	(	PUNCT
admet-291	32	67	d	d	NOUN
admet-291	32	68	)	)	PUNCT
admet-291	32	69	number	number	NOUN
admet-291	32	70	of	of	ADP
admet-291	32	71	hydrogenbond	hydrogenbond	ADJ
admet-291	32	72	acceptors	acceptor	NOUN
admet-291	32	73	,	,	PUNCT
admet-291	32	74	(	(	PUNCT
admet-291	32	75	o	o	NOUN
admet-291	32	76	plus	plus	CCONJ
admet-291	32	77	n	n	PRON
admet-291	32	78	atoms	atom	NOUN
admet-291	32	79	)	)	PUNCT
admet-291	32	80	<	<	X
admet-291	32	81	10	10	NUM
admet-291	32	82	.	.	PUNCT
admet-291	33	1	these	these	DET
admet-291	33	2	four	four	NUM
admet-291	33	3	physicochemical	physicochemical	ADJ
admet-291	33	4	properties	property	NOUN
admet-291	33	5	and	and	CCONJ
admet-291	33	6	their	their	PRON
admet-291	33	7	endpoints	endpoint	NOUN
admet-291	33	8	are	be	AUX
admet-291	33	9	associated	associate	VERB
admet-291	33	10	with	with	ADP
admet-291	33	11	acceptable	acceptable	ADJ
admet-291	33	12	aqueous	aqueous	ADJ
admet-291	33	13	solubility	solubility	NOUN
admet-291	33	14	and	and	CCONJ
admet-291	33	15	intestinal	intestinal	ADJ
admet-291	33	16	permeability	permeability	NOUN
admet-291	33	17	,	,	PUNCT
admet-291	33	18	the	the	DET
admet-291	33	19	important	important	ADJ
admet-291	33	20	first	first	ADJ
admet-291	33	21	step	step	NOUN
admet-291	33	22	of	of	ADP
admet-291	33	23	oral	oral	ADJ
admet-291	33	24	bioavailability	bioavailability	NOUN
admet-291	33	25	[	[	X
admet-291	33	26	11	11	NUM
admet-291	33	27	]	]	PUNCT
admet-291	33	28	.	.	PUNCT
admet-291	34	1	after	after	ADP
admet-291	34	2	the	the	DET
admet-291	34	3	lipinski	lipinski	PROPN
admet-291	34	4	’s	’s	PART
admet-291	34	5	ro5	ro5	PROPN
admet-291	34	6	,	,	PUNCT
admet-291	34	7	various	various	ADJ
admet-291	34	8	other	other	ADJ
admet-291	34	9	ways	way	NOUN
admet-291	34	10	of	of	ADP
admet-291	34	11	predicting	predict	VERB
admet-291	34	12	the	the	DET
admet-291	34	13	drug	drug	NOUN
admet-291	34	14	-	-	PUNCT
admet-291	34	15	like	like	ADJ
admet-291	34	16	space	space	NOUN
admet-291	34	17	for	for	ADP
admet-291	34	18	rational	rational	ADJ
admet-291	34	19	design	design	NOUN
admet-291	34	20	purposes	purpose	NOUN
admet-291	34	21	have	have	AUX
admet-291	34	22	been	be	AUX
admet-291	34	23	introduced	introduce	VERB
admet-291	34	24	by	by	ADP
admet-291	34	25	other	other	ADJ
admet-291	34	26	people	people	NOUN
admet-291	34	27	.	.	PUNCT
admet-291	35	1	veber	veber	PROPN
admet-291	35	2	et	et	PROPN
admet-291	35	3	al	al	PROPN
admet-291	35	4	.	.	PROPN
admet-291	35	5	2002	2002	NUM
admet-291	35	6	,	,	PUNCT
admet-291	35	7	showed	show	VERB
admet-291	35	8	that	that	SCONJ
admet-291	35	9	molecular	molecular	ADJ
admet-291	35	10	weight	weight	NOUN
admet-291	35	11	cutoff	cutoff	NOUN
admet-291	35	12	at	at	ADP
admet-291	35	13	500	500	NUM
admet-291	35	14	da	da	NOUN
admet-291	35	15	does	do	AUX
admet-291	35	16	not	not	PART
admet-291	35	17	itself	itself	PRON
admet-291	35	18	significantly	significantly	ADV
admet-291	35	19	separate	separate	ADJ
admet-291	35	20	compounds	compound	NOUN
admet-291	35	21	with	with	ADP
admet-291	35	22	poor	poor	ADJ
admet-291	35	23	oral	oral	ADJ
admet-291	35	24	bioavailability	bioavailability	NOUN
admet-291	35	25	from	from	ADP
admet-291	35	26	those	those	PRON
admet-291	35	27	with	with	ADP
admet-291	35	28	acceptable	acceptable	ADJ
admet-291	35	29	values	value	NOUN
admet-291	35	30	based	base	VERB
admet-291	35	31	on	on	ADP
admet-291	35	32	the	the	DET
admet-291	35	33	oral	oral	ADJ
admet-291	35	34	bioavailability	bioavailability	NOUN
admet-291	35	35	measurements	measurement	NOUN
admet-291	35	36	in	in	ADP
admet-291	35	37	rats	rat	NOUN
admet-291	35	38	for	for	ADP
admet-291	35	39	glaxosmithkline	glaxosmithkline	PROPN
admet-291	35	40	database	database	NOUN
admet-291	35	41	of	of	ADP
admet-291	35	42	almost	almost	ADV
admet-291	35	43	1100	1100	NUM
admet-291	35	44	drug	drug	NOUN
admet-291	35	45	candidates	candidate	NOUN
admet-291	35	46	[	[	X
admet-291	35	47	12	12	NUM
admet-291	35	48	]	]	PUNCT
admet-291	35	49	.	.	PUNCT
admet-291	36	1	he	he	PRON
admet-291	36	2	suggested	suggest	VERB
admet-291	36	3	that	that	SCONJ
admet-291	36	4	compounds	compound	NOUN
admet-291	36	5	having	have	VERB
admet-291	36	6	two	two	NUM
admet-291	36	7	criteria	criterion	NOUN
admet-291	36	8	of	of	ADP
admet-291	36	9	(	(	PUNCT
admet-291	36	10	1	1	NUM
admet-291	36	11	)	)	PUNCT
admet-291	36	12	number	number	NOUN
admet-291	36	13	of	of	ADP
admet-291	36	14	rotatable	rotatable	ADJ
admet-291	36	15	bonds	bond	NOUN
admet-291	36	16	(	(	PUNCT
admet-291	36	17	nrot	nrot	NOUN
admet-291	36	18	)	)	PUNCT
admet-291	36	19	≤	≤	NOUN
admet-291	36	20	10	10	NUM
admet-291	36	21	,	,	PUNCT
admet-291	36	22	(	(	PUNCT
admet-291	36	23	2	2	X
admet-291	36	24	)	)	PUNCT
admet-291	36	25	tpsa	tpsa	NOUN
admet-291	36	26	≤	≤	NUM
admet-291	36	27	140	140	NUM
admet-291	36	28	å2	å2	NOUN
admet-291	36	29	will	will	AUX
admet-291	36	30	have	have	VERB
admet-291	36	31	a	a	DET
admet-291	36	32	high	high	ADJ
admet-291	36	33	probability	probability	NOUN
admet-291	36	34	of	of	ADP
admet-291	36	35	good	good	ADJ
admet-291	36	36	oral	oral	ADJ
admet-291	36	37	bioavailability	bioavailability	NOUN
admet-291	36	38	.	.	PUNCT
admet-291	37	1	another	another	DET
admet-291	37	2	effective	effective	ADJ
admet-291	37	3	range	range	NOUN
admet-291	37	4	of	of	ADP
admet-291	37	5	physicochemical	physicochemical	ADJ
admet-291	37	6	properties	property	NOUN
admet-291	37	7	provided	provide	VERB
admet-291	37	8	by	by	ADP
admet-291	37	9	ghose	ghose	PROPN
admet-291	37	10	et	et	PROPN
admet-291	37	11	al	al	PROPN
admet-291	37	12	.	.	PROPN
admet-291	37	13	1999	1999	NUM
admet-291	37	14	,	,	PUNCT
admet-291	37	15	based	base	VERB
admet-291	37	16	on	on	ADP
admet-291	37	17	comprehensive	comprehensive	ADJ
admet-291	37	18	medicinal	medicinal	ADJ
admet-291	37	19	chemistry	chemistry	NOUN
admet-291	37	20	(	(	PUNCT
admet-291	37	21	cmc	cmc	NOUN
admet-291	37	22	)	)	PUNCT
admet-291	37	23	database	database	NOUN
admet-291	37	24	can	can	AUX
admet-291	37	25	be	be	AUX
admet-291	37	26	used	use	VERB
admet-291	37	27	in	in	ADP
admet-291	37	28	the	the	DET
admet-291	37	29	design	design	NOUN
admet-291	37	30	of	of	ADP
admet-291	37	31	drug	drug	NOUN
admet-291	37	32	-	-	PUNCT
admet-291	37	33	like	like	ADJ
admet-291	37	34	deepika	deepika	PROPN
admet-291	37	35	singh	singh	PROPN
admet-291	37	36	admet	admet	PROPN
admet-291	37	37	&	&	CCONJ
admet-291	37	38	dmpk	dmpk	PROPN
admet-291	37	39	4(2	4(2	NUM
admet-291	37	40	)	)	PUNCT
admet-291	37	41	(	(	PUNCT
admet-291	37	42	2016	2016	NUM
admet-291	37	43	)	)	PUNCT
admet-291	37	44	98	98	NUM
admet-291	37	45	-	-	SYM
admet-291	37	46	113	113	NUM
admet-291	37	47	100	100	NUM
admet-291	37	48	combinatorial	combinatorial	ADJ
admet-291	37	49	libraries	library	NOUN
admet-291	37	50	[	[	X
admet-291	37	51	13	13	NUM
admet-291	37	52	]	]	PUNCT
admet-291	37	53	.	.	PUNCT
admet-291	38	1	to	to	PART
admet-291	38	2	go	go	VERB
admet-291	38	3	beyond	beyond	ADP
admet-291	38	4	the	the	DET
admet-291	38	5	properties	property	NOUN
admet-291	38	6	associated	associate	VERB
admet-291	38	7	with	with	ADP
admet-291	38	8	the	the	DET
admet-291	38	9	ro5	ro5	ADJ
admet-291	38	10	and	and	CCONJ
admet-291	38	11	other	other	ADJ
admet-291	38	12	drug	drug	NOUN
admet-291	38	13	-	-	PUNCT
admet-291	38	14	like	like	ADJ
admet-291	38	15	filters	filter	NOUN
admet-291	38	16	,	,	PUNCT
admet-291	38	17	we	we	PRON
admet-291	38	18	became	become	VERB
admet-291	38	19	interested	interested	ADJ
admet-291	38	20	in	in	ADP
admet-291	38	21	developing	develop	VERB
admet-291	38	22	a	a	DET
admet-291	38	23	holistic	holistic	ADJ
admet-291	38	24	understanding	understanding	NOUN
admet-291	38	25	of	of	ADP
admet-291	38	26	physicochemical	physicochemical	ADJ
admet-291	38	27	property	property	NOUN
admet-291	38	28	space	space	NOUN
admet-291	38	29	for	for	ADP
admet-291	38	30	anticancer	anticancer	NOUN
admet-291	38	31	molecules	molecule	NOUN
admet-291	38	32	by	by	ADP
admet-291	38	33	carrying	carry	VERB
admet-291	38	34	out	out	ADP
admet-291	38	35	a	a	DET
admet-291	38	36	thorough	thorough	ADJ
admet-291	38	37	analysis	analysis	NOUN
admet-291	38	38	of	of	ADP
admet-291	38	39	properties	property	NOUN
admet-291	38	40	for	for	ADP
admet-291	38	41	natural	natural	ADJ
admet-291	38	42	product	product	NOUN
admet-291	38	43	derived	derive	VERB
admet-291	38	44	anticancer	anticancer	NOUN
admet-291	38	45	drugs	drug	NOUN
admet-291	38	46	and	and	CCONJ
admet-291	38	47	a	a	DET
admet-291	38	48	set	set	NOUN
admet-291	38	49	of	of	ADP
admet-291	38	50	natural	natural	ADJ
admet-291	38	51	product	product	NOUN
admet-291	38	52	lead	lead	NOUN
admet-291	38	53	anticancer	anticancer	NOUN
admet-291	38	54	molecules	molecule	NOUN
admet-291	38	55	,	,	PUNCT
admet-291	38	56	as	as	SCONJ
admet-291	38	57	most	most	ADJ
admet-291	38	58	of	of	ADP
admet-291	38	59	the	the	DET
admet-291	38	60	anticancer	anticancer	NOUN
admet-291	38	61	drugs	drug	NOUN
admet-291	38	62	have	have	AUX
admet-291	38	63	been	be	AUX
admet-291	38	64	derived	derive	VERB
admet-291	38	65	from	from	ADP
admet-291	38	66	the	the	DET
admet-291	38	67	natural	natural	ADJ
admet-291	38	68	products	product	NOUN
admet-291	38	69	[	[	X
admet-291	38	70	14	14	NUM
admet-291	38	71	]	]	SYM
admet-291	38	72	.	.	PUNCT
admet-291	39	1	herein	herein	NOUN
admet-291	39	2	,	,	PUNCT
admet-291	39	3	we	we	PRON
admet-291	39	4	present	present	VERB
admet-291	39	5	our	our	PRON
admet-291	39	6	efforts	effort	NOUN
admet-291	39	7	to	to	PART
admet-291	39	8	develop	develop	VERB
admet-291	39	9	a	a	DET
admet-291	39	10	prospective	prospective	ADJ
admet-291	39	11	mpo	mpo	NOUN
admet-291	39	12	design	design	NOUN
admet-291	39	13	tool	tool	NOUN
admet-291	39	14	for	for	ADP
admet-291	39	15	anti	anti	ADJ
admet-291	39	16	cancer	cancer	NOUN
admet-291	39	17	molecules	molecule	NOUN
admet-291	39	18	that	that	PRON
admet-291	39	19	does	do	AUX
admet-291	39	20	not	not	PART
admet-291	39	21	focus	focus	VERB
admet-291	39	22	on	on	ADP
admet-291	39	23	hard	hard	ADJ
admet-291	39	24	cutoffs	cutoff	NOUN
admet-291	39	25	or	or	CCONJ
admet-291	39	26	single	single	ADJ
admet-291	39	27	end	end	NOUN
admet-291	39	28	points	point	NOUN
admet-291	39	29	but	but	CCONJ
admet-291	39	30	utilizes	utilize	VERB
admet-291	39	31	the	the	DET
admet-291	39	32	eight	eight	NUM
admet-291	39	33	essential	essential	ADJ
admet-291	39	34	physicochemical	physicochemical	ADJ
admet-291	39	35	properties	property	NOUN
admet-291	39	36	to	to	PART
admet-291	39	37	prospectively	prospectively	VERB
admet-291	39	38	align	align	VERB
admet-291	39	39	drug	drug	NOUN
admet-291	39	40	like	like	ADP
admet-291	39	41	attributes	attribute	NOUN
admet-291	39	42	such	such	ADJ
admet-291	39	43	as	as	ADP
admet-291	39	44	high	high	ADJ
admet-291	39	45	permeability	permeability	NOUN
admet-291	39	46	,	,	PUNCT
admet-291	39	47	low	low	ADJ
admet-291	39	48	p	p	NOUN
admet-291	39	49	-	-	PUNCT
admet-291	39	50	gp	gp	NOUN
admet-291	39	51	efflux	efflux	NOUN
admet-291	39	52	liability	liability	NOUN
admet-291	39	53	,	,	PUNCT
admet-291	39	54	low	low	ADJ
admet-291	39	55	metabolic	metabolic	NOUN
admet-291	39	56	clearance	clearance	NOUN
admet-291	39	57	,	,	PUNCT
admet-291	39	58	and	and	CCONJ
admet-291	39	59	high	high	ADJ
admet-291	39	60	safety	safety	NOUN
admet-291	39	61	into	into	ADP
admet-291	39	62	one	one	NUM
admet-291	39	63	molecule	molecule	NOUN
admet-291	39	64	.	.	PUNCT
admet-291	40	1	in	in	ADP
admet-291	40	2	order	order	NOUN
admet-291	40	3	to	to	PART
admet-291	40	4	increase	increase	VERB
admet-291	40	5	the	the	DET
admet-291	40	6	flexibility	flexibility	NOUN
admet-291	40	7	in	in	ADP
admet-291	40	8	design	design	NOUN
admet-291	40	9	and	and	CCONJ
admet-291	40	10	probability	probability	NOUN
admet-291	40	11	of	of	ADP
admet-291	40	12	identifying	identify	VERB
admet-291	40	13	candidates	candidate	NOUN
admet-291	40	14	with	with	ADP
admet-291	40	15	optimal	optimal	ADJ
admet-291	40	16	pharmacokinetic	pharmacokinetic	ADJ
admet-291	40	17	and	and	CCONJ
admet-291	40	18	safety	safety	NOUN
admet-291	40	19	profile	profile	NOUN
admet-291	40	20	,	,	PUNCT
admet-291	40	21	we	we	PRON
admet-291	40	22	should	should	AUX
admet-291	40	23	not	not	PART
admet-291	40	24	use	use	VERB
admet-291	40	25	hard	hard	ADJ
admet-291	40	26	cutoffs	cutoff	NOUN
admet-291	40	27	or	or	CCONJ
admet-291	40	28	focus	focus	VERB
admet-291	40	29	on	on	ADP
admet-291	40	30	a	a	DET
admet-291	40	31	single	single	ADJ
admet-291	40	32	property	property	NOUN
admet-291	40	33	,	,	PUNCT
admet-291	40	34	as	as	SCONJ
admet-291	40	35	it	it	PRON
admet-291	40	36	may	may	AUX
admet-291	40	37	restrict	restrict	VERB
admet-291	40	38	design	design	NOUN
admet-291	40	39	space	space	NOUN
admet-291	40	40	and	and	CCONJ
admet-291	40	41	may	may	AUX
admet-291	40	42	not	not	PART
admet-291	40	43	align	align	VERB
admet-291	40	44	multiple	multiple	ADJ
admet-291	40	45	attributes	attribute	NOUN
admet-291	40	46	at	at	ADP
admet-291	40	47	once	once	ADV
admet-291	40	48	.	.	PUNCT
admet-291	41	1	experimental	experimental	ADJ
admet-291	41	2	admet	admet	PROPN
admet-291	41	3	property	property	NOUN
admet-291	41	4	calculations	calculation	NOUN
admet-291	41	5	poor	poor	ADJ
admet-291	41	6	pharmacokinetic	pharmacokinetic	ADJ
admet-291	41	7	properties	property	NOUN
admet-291	41	8	are	be	AUX
admet-291	41	9	one	one	NUM
admet-291	41	10	of	of	ADP
admet-291	41	11	the	the	DET
admet-291	41	12	main	main	ADJ
admet-291	41	13	reasons	reason	NOUN
admet-291	41	14	for	for	ADP
admet-291	41	15	terminating	terminate	VERB
admet-291	41	16	the	the	DET
admet-291	41	17	development	development	NOUN
admet-291	41	18	of	of	ADP
admet-291	41	19	drug	drug	NOUN
admet-291	41	20	candidates	candidate	NOUN
admet-291	41	21	.	.	PUNCT
admet-291	42	1	computed	compute	VERB
admet-291	42	2	physicochemical	physicochemical	ADJ
admet-291	42	3	properties	property	NOUN
admet-291	42	4	associated	associate	VERB
admet-291	42	5	with	with	ADP
admet-291	42	6	compounds	compound	NOUN
admet-291	42	7	that	that	PRON
admet-291	42	8	have	have	VERB
admet-291	42	9	good	good	ADJ
admet-291	42	10	oral	oral	ADJ
admet-291	42	11	bioavailability	bioavailability	NOUN
admet-291	42	12	,	,	PUNCT
admet-291	42	13	less	less	ADJ
admet-291	42	14	or	or	CCONJ
admet-291	42	15	no	no	PRON
admet-291	42	16	toxicity	toxicity	NOUN
admet-291	42	17	and	and	CCONJ
admet-291	42	18	optimum	optimum	ADJ
admet-291	42	19	values	value	NOUN
admet-291	42	20	of	of	ADP
admet-291	42	21	physicochemical	physicochemical	ADJ
admet-291	42	22	properties	property	NOUN
admet-291	42	23	are	be	AUX
admet-291	42	24	key	key	ADJ
admet-291	42	25	parameters	parameter	NOUN
admet-291	42	26	for	for	ADP
admet-291	42	27	the	the	DET
admet-291	42	28	anti	anti	PROPN
admet-291	42	29	cancer	cancer	NOUN
admet-291	42	30	drug	drug	NOUN
admet-291	42	31	discovery	discovery	NOUN
admet-291	42	32	,	,	PUNCT
admet-291	42	33	and	and	CCONJ
admet-291	42	34	we	we	PRON
admet-291	42	35	need	need	VERB
admet-291	42	36	compounds	compound	NOUN
admet-291	42	37	with	with	ADP
admet-291	42	38	good	good	ADJ
admet-291	42	39	pharmacokinetic	pharmacokinetic	ADJ
admet-291	42	40	properties	property	NOUN
admet-291	42	41	[	[	X
admet-291	42	42	15	15	NUM
admet-291	42	43	,	,	PUNCT
admet-291	42	44	16	16	NUM
admet-291	42	45	]	]	PUNCT
admet-291	42	46	.	.	PUNCT
admet-291	43	1	the	the	DET
admet-291	43	2	drug	drug	NOUN
admet-291	43	3	set	set	VERB
admet-291	43	4	used	use	VERB
admet-291	43	5	in	in	ADP
admet-291	43	6	this	this	DET
admet-291	43	7	study	study	NOUN
admet-291	43	8	includes	include	VERB
admet-291	43	9	24	24	NUM
admet-291	43	10	natural	natural	ADJ
admet-291	43	11	product	product	NOUN
admet-291	43	12	derived	derive	VERB
admet-291	43	13	anti	anti	NOUN
admet-291	43	14	cancer	cancer	NOUN
admet-291	43	15	drugs	drug	NOUN
admet-291	43	16	and	and	CCONJ
admet-291	43	17	structure	structure	NOUN
admet-291	43	18	of	of	ADP
admet-291	43	19	these	these	DET
admet-291	43	20	drugs	drug	NOUN
admet-291	43	21	are	be	AUX
admet-291	43	22	mentioned	mention	VERB
admet-291	43	23	in	in	ADP
admet-291	43	24	figure	figure	NOUN
admet-291	43	25	1	1	NUM
admet-291	43	26	.	.	PUNCT
admet-291	43	27	to	to	ADP
admet-291	43	28	the	the	DET
admet-291	43	29	best	good	ADJ
admet-291	43	30	of	of	ADP
admet-291	43	31	our	our	PRON
admet-291	43	32	knowledge	knowledge	NOUN
admet-291	43	33	,	,	PUNCT
admet-291	43	34	all	all	DET
admet-291	43	35	compounds	compound	NOUN
admet-291	43	36	in	in	ADP
admet-291	43	37	the	the	DET
admet-291	43	38	drug	drug	NOUN
admet-291	43	39	set	set	NOUN
admet-291	43	40	could	could	AUX
admet-291	43	41	be	be	AUX
admet-291	43	42	used	use	VERB
admet-291	43	43	as	as	ADP
admet-291	43	44	oral	oral	ADJ
admet-291	43	45	agents	agent	NOUN
admet-291	43	46	[	[	X
admet-291	43	47	17	17	NUM
admet-291	43	48	]	]	PUNCT
admet-291	43	49	.	.	PUNCT
admet-291	44	1	the	the	DET
admet-291	44	2	lead	lead	ADJ
admet-291	44	3	candidates	candidate	NOUN
admet-291	44	4	included	include	VERB
admet-291	44	5	in	in	ADP
admet-291	44	6	our	our	PRON
admet-291	44	7	analysis	analysis	NOUN
admet-291	44	8	consisted	consist	VERB
admet-291	44	9	of	of	ADP
admet-291	44	10	27	27	NUM
admet-291	44	11	natural	natural	ADJ
admet-291	44	12	products	product	NOUN
admet-291	44	13	derived	derive	VERB
admet-291	44	14	anti	anti	NOUN
admet-291	44	15	cancer	cancer	NOUN
admet-291	44	16	compounds	compound	NOUN
admet-291	44	17	that	that	PRON
admet-291	44	18	collected	collect	VERB
admet-291	44	19	from	from	ADP
admet-291	44	20	the	the	DET
admet-291	44	21	literature	literature	NOUN
admet-291	44	22	belong	belong	VERB
admet-291	44	23	to	to	ADP
admet-291	44	24	the	the	DET
admet-291	44	25	several	several	ADJ
admet-291	44	26	chemical	chemical	NOUN
admet-291	44	27	classes	class	NOUN
admet-291	44	28	as	as	SCONJ
admet-291	44	29	shown	show	VERB
admet-291	44	30	in	in	ADP
admet-291	44	31	figure	figure	NOUN
admet-291	44	32	2	2	NUM
admet-291	45	1	[	[	X
admet-291	45	2	18	18	NUM
admet-291	45	3	]	]	PUNCT
admet-291	45	4	.	.	PUNCT
admet-291	46	1	a	a	DET
admet-291	46	2	complete	complete	ADJ
admet-291	46	3	list	list	NOUN
admet-291	46	4	of	of	ADP
admet-291	46	5	the	the	DET
admet-291	46	6	drugs	drug	NOUN
admet-291	46	7	and	and	CCONJ
admet-291	46	8	lead	lead	ADJ
admet-291	46	9	candidates	candidate	NOUN
admet-291	46	10	used	use	VERB
admet-291	46	11	in	in	ADP
admet-291	46	12	the	the	DET
admet-291	46	13	analysis	analysis	NOUN
admet-291	46	14	appears	appear	VERB
admet-291	46	15	in	in	ADP
admet-291	46	16	table	table	NOUN
admet-291	46	17	1	1	NUM
admet-291	46	18	.	.	PUNCT
admet-291	46	19	admet	admet	PROPN
admet-291	46	20	related	relate	VERB
admet-291	46	21	physicochemical	physicochemical	ADJ
admet-291	46	22	properties	property	NOUN
admet-291	46	23	for	for	ADP
admet-291	46	24	24	24	NUM
admet-291	46	25	natural	natural	ADJ
admet-291	46	26	product	product	NOUN
admet-291	46	27	derived	derive	VERB
admet-291	46	28	anticancer	anticancer	NOUN
admet-291	46	29	drugs	drug	NOUN
admet-291	46	30	including	include	VERB
admet-291	46	31	clinical	clinical	ADJ
admet-291	46	32	development	development	NOUN
admet-291	46	33	candidates	candidate	NOUN
admet-291	46	34	and	and	CCONJ
admet-291	46	35	27	27	NUM
admet-291	46	36	natural	natural	ADJ
admet-291	46	37	product	product	NOUN
admet-291	46	38	lead	lead	NOUN
admet-291	46	39	anticancer	anticancer	NOUN
admet-291	46	40	compounds	compound	NOUN
admet-291	46	41	were	be	AUX
admet-291	46	42	predicted	predict	VERB
admet-291	46	43	using	use	VERB
admet-291	46	44	osiris	osiris	PROPN
admet-291	46	45	datawarrior	datawarrior	ADJ
admet-291	46	46	version	version	NOUN
admet-291	46	47	4.2.2	4.2.2	NUM
admet-291	46	48	software	software	NOUN
admet-291	46	49	on	on	ADP
admet-291	46	50	a	a	DET
admet-291	46	51	windows	window	NOUN
admet-291	46	52	xp	xp	NOUN
admet-291	46	53	operating	operating	NOUN
admet-291	46	54	system	system	NOUN
admet-291	46	55	[	[	X
admet-291	46	56	19	19	NUM
admet-291	46	57	]	]	PUNCT
admet-291	46	58	.	.	PUNCT
admet-291	47	1	datawarrior	datawarrior	ADJ
admet-291	47	2	is	be	AUX
admet-291	47	3	able	able	ADJ
admet-291	47	4	to	to	PART
admet-291	47	5	calculate	calculate	VERB
admet-291	47	6	physicochemical	physicochemical	ADJ
admet-291	47	7	properties	property	NOUN
admet-291	47	8	,	,	PUNCT
admet-291	47	9	leador	leador	ADJ
admet-291	47	10	drug	drug	NOUN
admet-291	47	11	-	-	PUNCT
admet-291	47	12	likeness	likeness	NOUN
admet-291	47	13	related	relate	VERB
admet-291	47	14	parameters	parameter	NOUN
admet-291	47	15	,	,	PUNCT
admet-291	47	16	ligand	ligand	NOUN
admet-291	47	17	efficiencies	efficiency	NOUN
admet-291	47	18	,	,	PUNCT
admet-291	47	19	various	various	ADJ
admet-291	47	20	atom	atom	NOUN
admet-291	47	21	and	and	CCONJ
admet-291	47	22	ring	ring	NOUN
admet-291	47	23	counts	count	NOUN
admet-291	47	24	,	,	PUNCT
admet-291	47	25	molecular	molecular	ADJ
admet-291	47	26	shape	shape	NOUN
admet-291	47	27	,	,	PUNCT
admet-291	47	28	flexibility	flexibility	NOUN
admet-291	47	29	and	and	CCONJ
admet-291	47	30	complexity	complexity	NOUN
admet-291	47	31	as	as	ADV
admet-291	47	32	well	well	ADV
admet-291	47	33	as	as	ADP
admet-291	47	34	indications	indication	NOUN
admet-291	47	35	for	for	ADP
admet-291	47	36	potential	potential	ADJ
admet-291	47	37	toxicity	toxicity	NOUN
admet-291	47	38	.	.	PUNCT
admet-291	48	1	after	after	ADP
admet-291	48	2	calculating	calculate	VERB
admet-291	48	3	properties	property	NOUN
admet-291	48	4	,	,	PUNCT
admet-291	48	5	these	these	PRON
admet-291	48	6	are	be	AUX
admet-291	48	7	automatically	automatically	ADV
admet-291	48	8	added	add	VERB
admet-291	48	9	as	as	ADP
admet-291	48	10	new	new	ADJ
admet-291	48	11	columns	column	NOUN
admet-291	48	12	to	to	ADP
admet-291	48	13	the	the	DET
admet-291	48	14	data	datum	NOUN
admet-291	48	15	table	table	NOUN
admet-291	48	16	.	.	PUNCT
admet-291	49	1	chemical	chemical	NOUN
admet-291	49	2	structures	structure	NOUN
admet-291	49	3	for	for	ADP
admet-291	49	4	24	24	NUM
admet-291	49	5	natural	natural	ADJ
admet-291	49	6	product	product	NOUN
admet-291	49	7	derived	derive	VERB
admet-291	49	8	anticancer	anticancer	NOUN
admet-291	49	9	drugs	drug	NOUN
admet-291	49	10	including	include	VERB
admet-291	49	11	clinical	clinical	ADJ
admet-291	49	12	development	development	NOUN
admet-291	49	13	candidates	candidate	NOUN
admet-291	49	14	and	and	CCONJ
admet-291	49	15	27	27	NUM
admet-291	49	16	natural	natural	ADJ
admet-291	49	17	product	product	NOUN
admet-291	49	18	lead	lead	NOUN
admet-291	49	19	compounds	compound	NOUN
admet-291	49	20	were	be	AUX
admet-291	49	21	downloaded	download	VERB
admet-291	49	22	and	and	CCONJ
admet-291	49	23	saved	save	VERB
admet-291	49	24	individually	individually	ADV
admet-291	49	25	in	in	ADP
admet-291	49	26	3d	3d	PROPN
admet-291	49	27	sdf	sdf	PROPN
admet-291	49	28	format	format	NOUN
admet-291	49	29	from	from	ADP
admet-291	49	30	pubchem	pubchem	NOUN
admet-291	49	31	(	(	PUNCT
admet-291	49	32	www.pubchem.org	www.pubchem.org	PROPN
admet-291	49	33	)	)	PUNCT
admet-291	49	34	.	.	PUNCT
admet-291	50	1	datawarrior	datawarrior	ADJ
admet-291	50	2	is	be	AUX
admet-291	50	3	unable	unable	ADJ
admet-291	50	4	to	to	PART
admet-291	50	5	optimize	optimize	VERB
admet-291	50	6	structures	structure	NOUN
admet-291	50	7	;	;	PUNCT
admet-291	50	8	therefore	therefore	ADV
admet-291	50	9	,	,	PUNCT
admet-291	50	10	geometry	geometry	NOUN
admet-291	50	11	optimization	optimization	NOUN
admet-291	50	12	of	of	ADP
admet-291	50	13	the	the	DET
admet-291	50	14	molecules	molecule	NOUN
admet-291	50	15	was	be	AUX
admet-291	50	16	performed	perform	VERB
admet-291	50	17	in	in	ADP
admet-291	50	18	avogadro	avogadro	PROPN
admet-291	50	19	software	software	NOUN
admet-291	50	20	prior	prior	ADV
admet-291	50	21	to	to	ADP
admet-291	50	22	the	the	DET
admet-291	50	23	prediction	prediction	NOUN
admet-291	50	24	of	of	ADP
admet-291	50	25	physicochemical	physicochemical	ADJ
admet-291	50	26	properties	property	NOUN
admet-291	50	27	[	[	X
admet-291	50	28	20	20	NUM
admet-291	50	29	]	]	PUNCT
admet-291	50	30	.	.	PUNCT
admet-291	51	1	datawarrior	datawarrior	ADJ
admet-291	51	2	software	software	NOUN
admet-291	51	3	calculates	calculate	VERB
admet-291	51	4	the	the	DET
admet-291	51	5	descriptors	descriptor	NOUN
admet-291	51	6	as	as	ADP
admet-291	51	7	inputs	input	NOUN
admet-291	51	8	to	to	ADP
admet-291	51	9	independent	independent	ADJ
admet-291	51	10	mathematical	mathematical	ADJ
admet-291	51	11	models	model	NOUN
admet-291	51	12	to	to	PART
admet-291	51	13	estimate	estimate	VERB
admet-291	51	14	a	a	DET
admet-291	51	15	range	range	NOUN
admet-291	51	16	of	of	ADP
admet-291	51	17	admet	admet	PROPN
admet-291	51	18	values	value	NOUN
admet-291	51	19	at	at	ADP
admet-291	51	20	relevant	relevant	ADJ
admet-291	51	21	ph	ph	ADJ
admet-291	51	22	7.4	7.4	NUM
admet-291	51	23	.	.	PUNCT
admet-291	52	1	physicochemical	physicochemical	ADJ
admet-291	52	2	properties	property	NOUN
admet-291	52	3	of	of	ADP
admet-291	52	4	interest	interest	NOUN
admet-291	52	5	included	include	VERB
admet-291	52	6	predicted	predict	VERB
admet-291	52	7	lipophilicity	lipophilicity	NOUN
admet-291	52	8	(	(	PUNCT
admet-291	52	9	log	log	VERB
admet-291	52	10	p	p	PROPN
admet-291	52	11	)	)	PUNCT
admet-291	52	12	,	,	PUNCT
admet-291	52	13	predicted	predict	VERB
admet-291	52	14	aqueous	aqueous	ADJ
admet-291	52	15	solubility	solubility	NOUN
admet-291	52	16	(	(	PUNCT
admet-291	52	17	log	log	NOUN
admet-291	52	18	s	s	PART
admet-291	52	19	)	)	PUNCT
admet-291	52	20	,	,	PUNCT
admet-291	52	21	topological	topological	ADJ
admet-291	52	22	polar	polar	ADJ
admet-291	52	23	surface	surface	NOUN
admet-291	52	24	area	area	NOUN
admet-291	52	25	(	(	PUNCT
admet-291	52	26	tpsa	tpsa	PROPN
admet-291	52	27	)	)	PUNCT
admet-291	52	28	,	,	PUNCT
admet-291	52	29	molecular	molecular	ADJ
admet-291	52	30	weight	weight	NOUN
admet-291	52	31	(	(	PUNCT
admet-291	52	32	mw	mw	NOUN
admet-291	52	33	)	)	PUNCT
admet-291	52	34	,	,	PUNCT
admet-291	52	35	hydrogen	hydrogen	NOUN
admet-291	52	36	bond	bond	NOUN
admet-291	52	37	donor	donor	NOUN
admet-291	52	38	(	(	PUNCT
admet-291	52	39	hbd	hbd	PROPN
admet-291	52	40	)	)	PUNCT
admet-291	52	41	,	,	PUNCT
admet-291	52	42	hydrogen	hydrogen	NOUN
admet-291	52	43	bond	bond	NOUN
admet-291	52	44	acceptor	acceptor	NOUN
admet-291	52	45	(	(	PUNCT
admet-291	52	46	hba	hba	NOUN
admet-291	52	47	)	)	PUNCT
admet-291	52	48	,	,	PUNCT
admet-291	52	49	and	and	CCONJ
admet-291	52	50	number	number	NOUN
admet-291	52	51	of	of	ADP
admet-291	52	52	rotatable	rotatable	ADJ
admet-291	52	53	bonds	bond	NOUN
admet-291	52	54	(	(	PUNCT
admet-291	52	55	nrot	nrot	NOUN
admet-291	52	56	)	)	PUNCT
admet-291	52	57	.	.	PUNCT
admet-291	53	1	specific	specific	ADJ
admet-291	53	2	adme	adme	NOUN
admet-291	53	3	properties	property	NOUN
admet-291	53	4	of	of	ADP
admet-291	53	5	interest	interest	NOUN
admet-291	53	6	included	include	VERB
admet-291	53	7	predicted	predict	VERB
admet-291	53	8	distribution	distribution	NOUN
admet-291	53	9	coefficient	coefficient	NOUN
admet-291	53	10	at	at	ADP
admet-291	53	11	ph=7.4	ph=7.4	PROPN
admet-291	53	12	(	(	PUNCT
admet-291	53	13	log	log	NOUN
admet-291	53	14	d	d	NOUN
admet-291	53	15	)	)	PUNCT
admet-291	53	16	(	(	PUNCT
admet-291	53	17	value	value	NOUN
admet-291	53	18	predicted	predict	VERB
admet-291	53	19	by	by	ADP
admet-291	53	20	acd	acd	PROPN
admet-291	53	21	/	/	SYM
admet-291	53	22	labs	labs	PROPN
admet-291	53	23	,	,	PUNCT
admet-291	53	24	admet	admet	PROPN
admet-291	53	25	&	&	CCONJ
admet-291	53	26	dmpk	dmpk	PROPN
admet-291	53	27	4(2	4(2	NUM
admet-291	53	28	)	)	PUNCT
admet-291	53	29	(	(	PUNCT
admet-291	53	30	2016	2016	NUM
admet-291	53	31	)	)	PUNCT
admet-291	53	32	98	98	NUM
admet-291	53	33	-	-	SYM
admet-291	53	34	113	113	NUM
admet-291	53	35	defining	define	VERB
admet-291	53	36	natural	natural	ADJ
admet-291	53	37	product	product	NOUN
admet-291	53	38	derived	derive	VERB
admet-291	53	39	anticancer	anticancer	NOUN
admet-291	53	40	drug	drug	NOUN
admet-291	53	41	space	space	NOUN
admet-291	53	42	doi	doi	NOUN
admet-291	53	43	:	:	PUNCT
admet-291	53	44	10.5599	10.5599	NUM
admet-291	53	45	/	/	SYM
admet-291	53	46	admet.4.2.291	admet.4.2.291	PROPN
admet-291	53	47	101	101	NUM
admet-291	53	48	www.chemspider.com	www.chemspider.com	NOUN
admet-291	53	49	)	)	PUNCT
admet-291	53	50	,	,	PUNCT
admet-291	53	51	predicted	predict	VERB
admet-291	53	52	aqueous	aqueous	ADJ
admet-291	53	53	solubility	solubility	NOUN
admet-291	53	54	(	(	PUNCT
admet-291	53	55	log	log	NOUN
admet-291	53	56	s	s	PART
admet-291	53	57	)	)	PUNCT
admet-291	53	58	,	,	PUNCT
admet-291	53	59	quantitatively	quantitatively	ADV
admet-291	53	60	predicted	predict	VERB
admet-291	53	61	apparent	apparent	ADJ
admet-291	53	62	permeability	permeability	NOUN
admet-291	53	63	(	(	PUNCT
admet-291	53	64	papp	papp	NOUN
admet-291	53	65	caco-2	caco-2	NUM
admet-291	53	66	cell	cell	NOUN
admet-291	53	67	)	)	PUNCT
admet-291	53	68	,	,	PUNCT
admet-291	53	69	predicted	predict	VERB
admet-291	53	70	effective	effective	ADJ
admet-291	53	71	permeability	permeability	NOUN
admet-291	53	72	(	(	PUNCT
admet-291	53	73	peff	peff	PROPN
admet-291	53	74	)	)	PUNCT
admet-291	53	75	,	,	PUNCT
admet-291	53	76	and	and	CCONJ
admet-291	53	77	predicted	predict	VERB
admet-291	53	78	human	human	ADJ
admet-291	53	79	intestinal	intestinal	ADJ
admet-291	53	80	absorption	absorption	NOUN
admet-291	53	81	(	(	PUNCT
admet-291	53	82	hia	hia	PROPN
admet-291	53	83	)	)	PUNCT
admet-291	53	84	.	.	PUNCT
admet-291	54	1	in	in	ADP
admet-291	54	2	order	order	NOUN
admet-291	54	3	to	to	PART
admet-291	54	4	evaluate	evaluate	VERB
admet-291	54	5	the	the	DET
admet-291	54	6	distribution	distribution	NOUN
admet-291	54	7	of	of	ADP
admet-291	54	8	drugs	drug	NOUN
admet-291	54	9	and	and	CCONJ
admet-291	54	10	leads	lead	NOUN
admet-291	54	11	,	,	PUNCT
admet-291	54	12	we	we	PRON
admet-291	54	13	considered	consider	VERB
admet-291	54	14	two	two	NUM
admet-291	54	15	important	important	ADJ
admet-291	54	16	parameters	parameter	NOUN
admet-291	54	17	including	include	VERB
admet-291	54	18	a	a	DET
admet-291	54	19	fraction	fraction	NOUN
admet-291	54	20	of	of	ADP
admet-291	54	21	unbound	unbound	NOUN
admet-291	54	22	to	to	ADP
admet-291	54	23	plasma	plasma	NOUN
admet-291	54	24	proteins	protein	NOUN
admet-291	54	25	(	(	PUNCT
admet-291	54	26	fu	fu	NOUN
admet-291	54	27	)	)	PUNCT
admet-291	54	28	,	,	PUNCT
admet-291	54	29	and	and	CCONJ
admet-291	54	30	volume	volume	NOUN
admet-291	54	31	of	of	ADP
admet-291	54	32	distribution	distribution	NOUN
admet-291	54	33	(	(	PUNCT
admet-291	54	34	vdss	vdss	ADJ
admet-291	54	35	)	)	PUNCT
admet-291	54	36	,	,	PUNCT
admet-291	54	37	a	a	DET
admet-291	54	38	requirement	requirement	NOUN
admet-291	54	39	of	of	ADP
admet-291	54	40	all	all	DET
admet-291	54	41	clinical	clinical	ADJ
admet-291	54	42	candidate	candidate	NOUN
admet-291	54	43	through	through	ADP
admet-291	54	44	recently	recently	ADV
admet-291	54	45	developed	develop	VERB
admet-291	54	46	online	online	ADJ
admet-291	54	47	admet	admet	NOUN
admet-291	54	48	calculation	calculation	NOUN
admet-291	54	49	tool	tool	NOUN
admet-291	54	50	pkscm	pkscm	PROPN
admet-291	54	51	(	(	PUNCT
admet-291	54	52	http://bleoberis.bioc.cam.ac.uk/pkcsm/	http://bleoberis.bioc.cam.ac.uk/pkcsm/	NOUN
admet-291	54	53	)	)	PUNCT
admet-291	55	1	[	[	X
admet-291	55	2	21	21	NUM
admet-291	55	3	]	]	PUNCT
admet-291	55	4	.	.	PUNCT
admet-291	56	1	figure	figure	NOUN
admet-291	56	2	1	1	NUM
admet-291	56	3	.	.	PUNCT
admet-291	57	1	chemical	chemical	NOUN
admet-291	57	2	structures	structure	NOUN
admet-291	57	3	of	of	ADP
admet-291	57	4	24	24	NUM
admet-291	57	5	natural	natural	ADJ
admet-291	57	6	products	product	NOUN
admet-291	57	7	derived	derive	VERB
admet-291	57	8	anti	anti	ADJ
admet-291	57	9	cancer	cancer	NOUN
admet-291	57	10	drugs	drug	NOUN
admet-291	57	11	.	.	PUNCT
admet-291	58	1	to	to	PART
admet-291	58	2	determine	determine	VERB
admet-291	58	3	excretion	excretion	NOUN
admet-291	58	4	routes	route	NOUN
admet-291	58	5	,	,	PUNCT
admet-291	58	6	natural	natural	ADJ
admet-291	58	7	products	product	NOUN
admet-291	58	8	anticancer	anticancer	NOUN
admet-291	58	9	drugs	drug	NOUN
admet-291	58	10	and	and	CCONJ
admet-291	58	11	leads	lead	VERB
admet-291	58	12	we	we	PRON
admet-291	58	13	quantitatively	quantitatively	ADV
admet-291	58	14	predicted	predict	VERB
admet-291	58	15	the	the	DET
admet-291	58	16	total	total	ADJ
admet-291	58	17	clearance	clearance	NOUN
admet-291	58	18	and	and	CCONJ
admet-291	58	19	qualitatively	qualitatively	ADV
admet-291	58	20	predicted	predict	VERB
admet-291	58	21	renal	renal	ADJ
admet-291	58	22	oct2	oct2	NOUN
admet-291	58	23	substrate	substrate	NOUN
admet-291	58	24	.	.	PUNCT
admet-291	59	1	the	the	DET
admet-291	59	2	safety	safety	NOUN
admet-291	59	3	profile	profile	NOUN
admet-291	59	4	of	of	ADP
admet-291	59	5	compounds	compound	NOUN
admet-291	59	6	is	be	AUX
admet-291	59	7	one	one	NUM
admet-291	59	8	of	of	ADP
admet-291	59	9	the	the	DET
admet-291	59	10	most	most	ADV
admet-291	59	11	common	common	ADJ
admet-291	59	12	factors	factor	NOUN
admet-291	59	13	in	in	ADP
admet-291	59	14	drug	drug	NOUN
admet-291	59	15	attrition	attrition	NOUN
admet-291	59	16	(	(	PUNCT
admet-291	59	17	1	1	NUM
admet-291	59	18	)	)	PUNCT
admet-291	59	19	.	.	PUNCT
admet-291	60	1	as	as	ADP
admet-291	60	2	part	part	NOUN
admet-291	60	3	of	of	ADP
admet-291	60	4	our	our	PRON
admet-291	60	5	analysis	analysis	NOUN
admet-291	60	6	of	of	ADP
admet-291	60	7	properties	property	NOUN
admet-291	60	8	for	for	ADP
admet-291	60	9	natural	natural	ADJ
admet-291	60	10	products	product	NOUN
admet-291	60	11	anticancer	anticancer	NOUN
admet-291	60	12	drugs	drug	NOUN
admet-291	60	13	and	and	CCONJ
admet-291	60	14	leads	lead	NOUN
admet-291	60	15	,	,	PUNCT
admet-291	60	16	we	we	PRON
admet-291	60	17	assess	assess	VERB
admet-291	60	18	some	some	PRON
admet-291	60	19	of	of	ADP
admet-291	60	20	the	the	DET
admet-291	60	21	major	major	ADJ
admet-291	60	22	toxicity	toxicity	NOUN
admet-291	60	23	endpoints	endpoint	NOUN
admet-291	60	24	.	.	PUNCT
admet-291	61	1	we	we	PRON
admet-291	61	2	generated	generate	VERB
admet-291	61	3	in	in	ADP
admet-291	61	4	silico	silico	NOUN
admet-291	61	5	data	datum	NOUN
admet-291	61	6	to	to	PART
admet-291	61	7	assess	assess	VERB
admet-291	61	8	potential	potential	NOUN
admet-291	61	9	for	for	ADP
admet-291	61	10	the	the	DET
admet-291	61	11	following	follow	VERB
admet-291	61	12	safety	safety	NOUN
admet-291	61	13	risks	risk	NOUN
admet-291	61	14	:	:	PUNCT
admet-291	61	15	drug	drug	NOUN
admet-291	61	16	-	-	PUNCT
admet-291	61	17	drug	drug	NOUN
admet-291	61	18	interactions	interaction	NOUN
admet-291	61	19	(	(	PUNCT
admet-291	61	20	cyp	cyp	ADJ
admet-291	61	21	inhibitions	inhibition	NOUN
admet-291	61	22	)	)	PUNCT
admet-291	61	23	including	include	VERB
admet-291	61	24	cyp3a4	cyp3a4	PROPN
admet-291	61	25	,	,	PUNCT
admet-291	61	26	cyp2c9	cyp2c9	NOUN
admet-291	61	27	,	,	PUNCT
admet-291	61	28	and	and	CCONJ
admet-291	61	29	cyp2d6	cyp2d6	NOUN
admet-291	61	30	,	,	PUNCT
admet-291	61	31	herg	herg	PROPN
admet-291	61	32	liability	liability	NOUN
admet-291	61	33	(	(	PUNCT
admet-291	61	34	inhibition	inhibition	NOUN
admet-291	61	35	of	of	ADP
admet-291	61	36	dofetilide	dofetilide	ADJ
admet-291	61	37	binding	binding	NOUN
admet-291	61	38	)	)	PUNCT
admet-291	61	39	,	,	PUNCT
admet-291	61	40	predicted	predict	VERB
admet-291	61	41	ld50	ld50	PROPN
admet-291	61	42	,	,	PUNCT
admet-291	61	43	predicted	predict	VERB
admet-291	61	44	hepatotoxicity	hepatotoxicity	NOUN
admet-291	61	45	,	,	PUNCT
admet-291	61	46	predicted	predict	VERB
admet-291	61	47	skin	skin	NOUN
admet-291	61	48	sensitization	sensitization	NOUN
admet-291	61	49	,	,	PUNCT
admet-291	61	50	cellular	cellular	ADJ
admet-291	61	51	toxicity	toxicity	NOUN
admet-291	61	52	through	through	ADP
admet-291	61	53	pkscm	pkscm	PROPN
admet-291	61	54	tool	tool	NOUN
admet-291	61	55	and	and	CCONJ
admet-291	61	56	mutagenicity	mutagenicity	NOUN
admet-291	61	57	,	,	PUNCT
admet-291	61	58	tumorigenicity	tumorigenicity	NOUN
admet-291	61	59	and	and	CCONJ
admet-291	61	60	irritant	irritant	VERB
admet-291	61	61	effects	effect	NOUN
admet-291	61	62	through	through	ADP
admet-291	61	63	datawarrior	datawarrior	ADJ
admet-291	61	64	software	software	NOUN
admet-291	61	65	.	.	PUNCT
admet-291	62	1	to	to	PART
admet-291	62	2	access	access	VERB
admet-291	62	3	the	the	DET
admet-291	62	4	likelihood	likelihood	NOUN
admet-291	62	5	of	of	ADP
admet-291	62	6	binding	bind	VERB
admet-291	62	7	to	to	PART
admet-291	62	8	transporter	transporter	VERB
admet-291	62	9	permeability	permeability	NOUN
admet-291	62	10	-	-	PUNCT
admet-291	62	11	glycoprotein	glycoprotein	NOUN
admet-291	62	12	(	(	PUNCT
admet-291	62	13	p	p	NOUN
admet-291	62	14	-	-	PUNCT
admet-291	62	15	gp	gp	NOUN
admet-291	62	16	)	)	PUNCT
admet-291	62	17	,	,	PUNCT
admet-291	62	18	we	we	PRON
admet-291	62	19	used	use	VERB
admet-291	62	20	pgp_substrate	pgp_substrate	PROPN
admet-291	62	21	model	model	NOUN
admet-291	62	22	.	.	PUNCT
admet-291	63	1	we	we	PRON
admet-291	63	2	also	also	ADV
admet-291	63	3	calculated	calculate	VERB
admet-291	63	4	the	the	DET
admet-291	63	5	three	three	NUM
admet-291	63	6	most	most	ADV
admet-291	63	7	crucial	crucial	ADJ
admet-291	63	8	druglikeness	druglikeness	NOUN
admet-291	63	9	filters	filter	NOUN
admet-291	63	10	including	include	VERB
admet-291	63	11	lipinski	lipinski	PROPN
admet-291	63	12	,	,	PUNCT
admet-291	63	13	ghose	ghose	PROPN
admet-291	63	14	,	,	PUNCT
admet-291	63	15	and	and	CCONJ
admet-291	63	16	veber	veber	PROPN
admet-291	63	17	rules	rule	VERB
admet-291	63	18	as	as	ADV
admet-291	63	19	well	well	ADV
admet-291	63	20	as	as	ADP
admet-291	63	21	the	the	DET
admet-291	63	22	quantitative	quantitative	ADJ
admet-291	63	23	estimate	estimate	NOUN
admet-291	63	24	of	of	ADP
admet-291	63	25	drug	drug	NOUN
admet-291	63	26	-	-	PUNCT
admet-291	63	27	likeness	likeness	NOUN
admet-291	63	28	(	(	PUNCT
admet-291	63	29	qed	qed	PROPN
admet-291	63	30	)	)	PUNCT
admet-291	63	31	with	with	ADP
admet-291	63	32	the	the	DET
admet-291	63	33	drug	drug	NOUN
admet-291	63	34	likeness	likeness	NOUN
admet-291	63	35	tool	tool	NOUN
admet-291	63	36	(	(	PUNCT
admet-291	63	37	drulito	drulito	NOUN
admet-291	63	38	)	)	PUNCT
admet-291	63	39	software	software	NOUN
admet-291	63	40	(	(	PUNCT
admet-291	63	41	http://www.niper.gov.in/pi_dev_tools/drulitoweb/drulito_index.html	http://www.niper.gov.in/pi_dev_tools/drulitoweb/drulito_index.html	PROPN
admet-291	63	42	)	)	PUNCT
admet-291	63	43	.	.	PUNCT
admet-291	64	1	http://bleoberis.bioc.cam.ac.uk/pkcsm/	http://bleoberis.bioc.cam.ac.uk/pkcsm/	PROPN
admet-291	64	2	)	)	PUNCT
admet-291	65	1	http://www.niper.gov.in/pi_dev_tools/drulitoweb/drulito_index.html	http://www.niper.gov.in/pi_dev_tools/drulitoweb/drulito_index.html	PROPN
admet-291	65	2	deepika	deepika	PROPN
admet-291	65	3	singh	singh	PROPN
admet-291	65	4	admet	admet	PROPN
admet-291	65	5	&	&	CCONJ
admet-291	65	6	dmpk	dmpk	PROPN
admet-291	65	7	4(2	4(2	NUM
admet-291	65	8	)	)	PUNCT
admet-291	65	9	(	(	PUNCT
admet-291	65	10	2016	2016	NUM
admet-291	65	11	)	)	PUNCT
admet-291	65	12	98	98	NUM
admet-291	65	13	-	-	SYM
admet-291	65	14	113	113	NUM
admet-291	65	15	102	102	NUM
admet-291	65	16	figure	figure	NOUN
admet-291	65	17	2	2	NUM
admet-291	65	18	.	.	PUNCT
admet-291	65	19	chemical	chemical	NOUN
admet-291	65	20	structures	structure	NOUN
admet-291	65	21	of	of	ADP
admet-291	65	22	27	27	NUM
admet-291	65	23	natural	natural	ADJ
admet-291	65	24	products	product	NOUN
admet-291	65	25	derived	derive	VERB
admet-291	65	26	anti	anti	NOUN
admet-291	65	27	cancer	cancer	NOUN
admet-291	65	28	lead	lead	NOUN
admet-291	65	29	molecules	molecule	NOUN
admet-291	65	30	.	.	PUNCT
admet-291	66	1	results	result	NOUN
admet-291	66	2	and	and	CCONJ
admet-291	66	3	discussion	discussion	NOUN
admet-291	66	4	optimum	optimum	ADJ
admet-291	66	5	physicochemical	physicochemical	ADJ
admet-291	66	6	property	property	NOUN
admet-291	66	7	space	space	NOUN
admet-291	66	8	for	for	ADP
admet-291	66	9	anticancer	anticancer	NOUN
admet-291	66	10	molecules	molecule	NOUN
admet-291	66	11	the	the	DET
admet-291	66	12	24	24	NUM
admet-291	66	13	natural	natural	ADJ
admet-291	66	14	product	product	NOUN
admet-291	66	15	derived	derive	VERB
admet-291	66	16	anticancer	anticancer	NOUN
admet-291	66	17	drugs	drug	NOUN
admet-291	66	18	including	include	VERB
admet-291	66	19	clinical	clinical	ADJ
admet-291	66	20	development	development	NOUN
admet-291	66	21	candidates	candidate	NOUN
admet-291	66	22	and	and	CCONJ
admet-291	66	23	27	27	NUM
admet-291	66	24	natural	natural	ADJ
admet-291	66	25	product	product	NOUN
admet-291	66	26	lead	lead	NOUN
admet-291	66	27	anticancer	anticancer	NOUN
admet-291	66	28	compounds	compound	NOUN
admet-291	66	29	were	be	AUX
admet-291	66	30	evaluated	evaluate	VERB
admet-291	66	31	against	against	ADP
admet-291	66	32	a	a	DET
admet-291	66	33	set	set	NOUN
admet-291	66	34	of	of	ADP
admet-291	66	35	eight	eight	NUM
admet-291	66	36	calculated	calculate	VERB
admet-291	66	37	fundamental	fundamental	ADJ
admet-291	66	38	physicochemical	physicochemical	ADJ
admet-291	66	39	properties	property	NOUN
admet-291	66	40	that	that	PRON
admet-291	66	41	have	have	AUX
admet-291	66	42	gained	gain	VERB
admet-291	66	43	wide	wide	ADJ
admet-291	66	44	acceptance	acceptance	NOUN
admet-291	66	45	as	as	ADP
admet-291	66	46	key	key	ADJ
admet-291	66	47	parameters	parameter	NOUN
admet-291	66	48	for	for	ADP
admet-291	66	49	drug	drug	NOUN
admet-291	66	50	design	design	NOUN
admet-291	66	51	and	and	CCONJ
admet-291	66	52	development	development	NOUN
admet-291	66	53	:	:	PUNCT
admet-291	66	54	(	(	PUNCT
admet-291	66	55	a	a	X
admet-291	66	56	)	)	PUNCT
admet-291	66	57	lipophilicity	lipophilicity	NOUN
admet-291	66	58	,	,	PUNCT
admet-291	66	59	calculated	calculate	VERB
admet-291	66	60	partition	partition	NOUN
admet-291	66	61	coefficient	coefficient	NOUN
admet-291	66	62	(	(	PUNCT
admet-291	66	63	log	log	VERB
admet-291	66	64	p	p	PROPN
admet-291	66	65	)	)	PUNCT
admet-291	66	66	;	;	PUNCT
admet-291	66	67	(	(	PUNCT
admet-291	66	68	b	b	X
admet-291	66	69	)	)	PUNCT
admet-291	66	70	distribution	distribution	NOUN
admet-291	66	71	coefficient	coefficient	NOUN
admet-291	66	72	at	at	ADP
admet-291	66	73	ph=7.4	ph=7.4	PROPN
admet-291	66	74	(	(	PUNCT
admet-291	66	75	log	log	NOUN
admet-291	66	76	d	d	PROPN
admet-291	66	77	)	)	PUNCT
admet-291	66	78	;	;	PUNCT
admet-291	66	79	(	(	PUNCT
admet-291	66	80	c	c	X
admet-291	66	81	)	)	PUNCT
admet-291	66	82	molecular	molecular	ADJ
admet-291	66	83	weight	weight	NOUN
admet-291	66	84	(	(	PUNCT
admet-291	66	85	mw	mw	PROPN
admet-291	66	86	)	)	PUNCT
admet-291	66	87	;	;	PUNCT
admet-291	66	88	(	(	PUNCT
admet-291	66	89	d	d	X
admet-291	66	90	)	)	PUNCT
admet-291	66	91	topological	topological	ADJ
admet-291	66	92	polar	polar	ADJ
admet-291	66	93	surface	surface	NOUN
admet-291	66	94	area	area	NOUN
admet-291	66	95	(	(	PUNCT
admet-291	66	96	tpsa	tpsa	PROPN
admet-291	66	97	)	)	PUNCT
admet-291	66	98	;	;	PUNCT
admet-291	66	99	(	(	PUNCT
admet-291	66	100	e	e	NOUN
admet-291	66	101	)	)	PUNCT
admet-291	66	102	number	number	NOUN
admet-291	66	103	of	of	ADP
admet-291	66	104	hydrogen	hydrogen	NOUN
admet-291	66	105	bond	bond	NOUN
admet-291	66	106	donors	donor	NOUN
admet-291	66	107	(	(	PUNCT
admet-291	66	108	hbd	hbd	PROPN
admet-291	66	109	)	)	PUNCT
admet-291	66	110	;	;	PUNCT
admet-291	66	111	(	(	PUNCT
admet-291	66	112	f	f	X
admet-291	66	113	)	)	PUNCT
admet-291	66	114	hydrogen	hydrogen	NOUN
admet-291	66	115	bond	bond	NOUN
admet-291	66	116	acceptor	acceptor	NOUN
admet-291	66	117	(	(	PUNCT
admet-291	66	118	hba	hba	NOUN
admet-291	66	119	)	)	PUNCT
admet-291	66	120	,	,	PUNCT
admet-291	66	121	(	(	PUNCT
admet-291	66	122	g	g	NOUN
admet-291	66	123	)	)	PUNCT
admet-291	66	124	number	number	NOUN
admet-291	66	125	of	of	ADP
admet-291	66	126	rotatable	rotatable	ADJ
admet-291	66	127	bonds	bond	NOUN
admet-291	66	128	(	(	PUNCT
admet-291	66	129	nrot	nrot	X
admet-291	66	130	)	)	PUNCT
admet-291	66	131	and	and	CCONJ
admet-291	66	132	predicted	predict	VERB
admet-291	66	133	aqueous	aqueous	ADJ
admet-291	66	134	solubility	solubility	NOUN
admet-291	66	135	(	(	PUNCT
admet-291	66	136	log	log	NOUN
admet-291	66	137	s	s	PART
admet-291	66	138	)	)	PUNCT
admet-291	67	1	[	[	X
admet-291	67	2	11	11	NUM
admet-291	67	3	,	,	PUNCT
admet-291	67	4	22	22	NUM
admet-291	67	5	]	]	PUNCT
admet-291	67	6	.	.	PUNCT
admet-291	68	1	the	the	DET
admet-291	68	2	calculated	calculate	VERB
admet-291	68	3	physicochemical	physicochemical	ADJ
admet-291	68	4	properties	property	NOUN
admet-291	68	5	value	value	VERB
admet-291	68	6	for	for	ADP
admet-291	68	7	the	the	DET
admet-291	68	8	drugs	drug	NOUN
admet-291	68	9	and	and	CCONJ
admet-291	68	10	leads	lead	NOUN
admet-291	68	11	are	be	AUX
admet-291	68	12	mentioned	mention	VERB
admet-291	68	13	in	in	ADP
admet-291	68	14	table	table	NOUN
admet-291	68	15	1	1	NUM
admet-291	68	16	.	.	PUNCT
admet-291	68	17	physicochemical	physicochemical	ADJ
admet-291	68	18	property	property	NOUN
admet-291	68	19	space	space	NOUN
admet-291	68	20	as	as	SCONJ
admet-291	68	21	captured	capture	VERB
admet-291	68	22	by	by	ADP
admet-291	68	23	these	these	DET
admet-291	68	24	eight	eight	NUM
admet-291	68	25	parameters	parameter	NOUN
admet-291	68	26	was	be	AUX
admet-291	68	27	quite	quite	ADV
admet-291	68	28	broad	broad	ADJ
admet-291	68	29	(	(	PUNCT
admet-291	68	30	figure	figure	NOUN
admet-291	68	31	3	3	NUM
admet-291	68	32	)	)	PUNCT
admet-291	68	33	.	.	PUNCT
admet-291	69	1	the	the	DET
admet-291	69	2	mw	mw	ADJ
admet-291	69	3	values	value	NOUN
admet-291	69	4	for	for	ADP
admet-291	69	5	the	the	DET
admet-291	69	6	drugs	drug	NOUN
admet-291	69	7	varied	varied	ADJ
admet-291	69	8	from	from	ADP
admet-291	69	9	246	246	NUM
admet-291	69	10	to	to	PART
admet-291	69	11	853	853	NUM
admet-291	69	12	with	with	ADP
admet-291	69	13	a	a	DET
admet-291	69	14	median	median	ADJ
admet-291	69	15	mw	mw	NOUN
admet-291	69	16	value	value	NOUN
admet-291	69	17	of	of	ADP
admet-291	69	18	514	514	NUM
admet-291	69	19	,	,	PUNCT
admet-291	69	20	while	while	SCONJ
admet-291	69	21	mw	mw	ADJ
admet-291	69	22	range	range	NOUN
admet-291	69	23	for	for	ADP
admet-291	69	24	leads	lead	NOUN
admet-291	69	25	is	be	AUX
admet-291	69	26	much	much	ADV
admet-291	69	27	broad	broad	ADJ
admet-291	69	28	and	and	CCONJ
admet-291	69	29	varied	varied	ADJ
admet-291	69	30	from	from	ADP
admet-291	69	31	114	114	NUM
admet-291	69	32	to	to	ADP
admet-291	69	33	975	975	NUM
admet-291	69	34	with	with	ADP
admet-291	69	35	a	a	DET
admet-291	69	36	median	median	ADJ
admet-291	69	37	value	value	NOUN
admet-291	69	38	of	of	ADP
admet-291	69	39	336	336	NUM
admet-291	69	40	.	.	PUNCT
admet-291	70	1	the	the	DET
admet-291	70	2	log	log	NOUN
admet-291	70	3	p	p	NOUN
admet-291	70	4	value	value	NOUN
admet-291	70	5	of	of	ADP
admet-291	70	6	the	the	DET
admet-291	70	7	drugs	drug	NOUN
admet-291	70	8	varied	varied	ADJ
admet-291	70	9	from	from	ADP
admet-291	70	10	0.46	0.46	NUM
admet-291	70	11	to	to	ADP
admet-291	70	12	4.67	4.67	NUM
admet-291	70	13	with	with	ADP
admet-291	70	14	a	a	DET
admet-291	70	15	median	median	ADJ
admet-291	70	16	log	log	NOUN
admet-291	70	17	p	p	NOUN
admet-291	70	18	value	value	NOUN
admet-291	70	19	of	of	ADP
admet-291	70	20	2.6	2.6	NUM
admet-291	70	21	.	.	PUNCT
admet-291	71	1	molecules	molecule	NOUN
admet-291	71	2	in	in	ADP
admet-291	71	3	the	the	DET
admet-291	71	4	lead	lead	NOUN
admet-291	71	5	set	set	VERB
admet-291	71	6	having	have	VERB
admet-291	71	7	the	the	DET
admet-291	71	8	log	log	NOUN
admet-291	71	9	p	p	NOUN
admet-291	71	10	value	value	NOUN
admet-291	71	11	from	from	ADP
admet-291	71	12	-2	-2	NOUN
admet-291	71	13	to	to	ADP
admet-291	71	14	16	16	NUM
admet-291	71	15	,	,	PUNCT
admet-291	71	16	which	which	PRON
admet-291	71	17	is	be	AUX
admet-291	71	18	quite	quite	ADV
admet-291	71	19	broad	broad	ADJ
admet-291	71	20	with	with	ADP
admet-291	71	21	a	a	DET
admet-291	71	22	median	median	NOUN
admet-291	71	23	of	of	ADP
admet-291	71	24	2.68	2.68	NUM
admet-291	71	25	.	.	PUNCT
admet-291	72	1	there	there	PRON
admet-291	72	2	was	be	VERB
admet-291	72	3	no	no	DET
admet-291	72	4	significant	significant	ADJ
admet-291	72	5	difference	difference	NOUN
admet-291	72	6	in	in	ADP
admet-291	72	7	the	the	DET
admet-291	72	8	median	median	ADJ
admet-291	72	9	log	log	NOUN
admet-291	72	10	p	p	NOUN
admet-291	72	11	values	value	NOUN
admet-291	72	12	between	between	ADP
admet-291	72	13	the	the	DET
admet-291	72	14	two	two	NUM
admet-291	72	15	sets	set	NOUN
admet-291	72	16	,	,	PUNCT
admet-291	72	17	although	although	SCONJ
admet-291	72	18	the	the	DET
admet-291	72	19	drug	drug	NOUN
admet-291	72	20	set	set	NOUN
admet-291	72	21	had	have	VERB
admet-291	72	22	a	a	DET
admet-291	72	23	lower	low	ADJ
admet-291	72	24	span	span	NOUN
admet-291	72	25	of	of	ADP
admet-291	72	26	log	log	NOUN
admet-291	72	27	p	p	NOUN
admet-291	72	28	values	value	NOUN
admet-291	72	29	.	.	PUNCT
admet-291	73	1	low	low	ADJ
admet-291	73	2	hydrophilicity	hydrophilicity	NOUN
admet-291	73	3	(	(	PUNCT
admet-291	73	4	e.g.	e.g.	ADV
admet-291	73	5	high	high	ADJ
admet-291	73	6	log	log	NOUN
admet-291	73	7	p	p	NOUN
admet-291	73	8	)	)	PUNCT
admet-291	73	9	values	value	NOUN
admet-291	73	10	can	can	AUX
admet-291	73	11	cause	cause	VERB
admet-291	73	12	poor	poor	ADJ
admet-291	73	13	absorption	absorption	NOUN
admet-291	73	14	or	or	CCONJ
admet-291	73	15	permeation	permeation	NOUN
admet-291	73	16	.	.	PUNCT
admet-291	74	1	our	our	PRON
admet-291	74	2	analysis	analysis	NOUN
admet-291	74	3	suggests	suggest	VERB
admet-291	74	4	that	that	SCONJ
admet-291	74	5	for	for	ADP
admet-291	74	6	anticancer	anticancer	NOUN
admet-291	74	7	drugs	drug	NOUN
admet-291	74	8	,	,	PUNCT
admet-291	74	9	there	there	PRON
admet-291	74	10	may	may	AUX
admet-291	74	11	be	be	AUX
admet-291	74	12	a	a	DET
admet-291	74	13	need	need	NOUN
admet-291	74	14	to	to	PART
admet-291	74	15	design	design	VERB
admet-291	74	16	compounds	compound	NOUN
admet-291	74	17	with	with	ADP
admet-291	74	18	further	far	ADV
admet-291	74	19	reduced	reduce	VERB
admet-291	74	20	log	log	PROPN
admet-291	74	21	p	p	NOUN
admet-291	74	22	or	or	CCONJ
admet-291	74	23	mw	mw	VERB
admet-291	74	24	to	to	PART
admet-291	74	25	better	well	ADV
admet-291	74	26	match	match	VERB
admet-291	74	27	the	the	DET
admet-291	74	28	corresponding	correspond	VERB
admet-291	74	29	properties	property	NOUN
admet-291	74	30	in	in	ADP
admet-291	74	31	the	the	DET
admet-291	74	32	drug	drug	NOUN
admet-291	74	33	set	set	NOUN
admet-291	74	34	.	.	PUNCT
admet-291	75	1	polarity	polarity	NOUN
admet-291	75	2	,	,	PUNCT
admet-291	75	3	as	as	SCONJ
admet-291	75	4	described	describe	VERB
admet-291	75	5	by	by	ADP
admet-291	75	6	polar	polar	ADJ
admet-291	75	7	surface	surface	NOUN
admet-291	75	8	area	area	NOUN
admet-291	75	9	(	(	PUNCT
admet-291	75	10	tpsa	tpsa	PROPN
admet-291	75	11	)	)	PUNCT
admet-291	75	12	,	,	PUNCT
admet-291	75	13	ranged	range	VERB
admet-291	75	14	from	from	ADP
admet-291	75	15	admet	admet	PROPN
admet-291	75	16	&	&	CCONJ
admet-291	75	17	dmpk	dmpk	PROPN
admet-291	75	18	4(2	4(2	NUM
admet-291	75	19	)	)	PUNCT
admet-291	75	20	(	(	PUNCT
admet-291	75	21	2016	2016	NUM
admet-291	75	22	)	)	PUNCT
admet-291	75	23	98	98	NUM
admet-291	75	24	-	-	SYM
admet-291	75	25	113	113	NUM
admet-291	75	26	defining	define	VERB
admet-291	75	27	natural	natural	ADJ
admet-291	75	28	product	product	NOUN
admet-291	75	29	derived	derive	VERB
admet-291	75	30	anticancer	anticancer	NOUN
admet-291	75	31	drug	drug	NOUN
admet-291	75	32	space	space	NOUN
admet-291	75	33	doi	doi	NOUN
admet-291	75	34	:	:	PUNCT
admet-291	75	35	10.5599	10.5599	NUM
admet-291	75	36	/	/	SYM
admet-291	75	37	admet.4.2.291	admet.4.2.291	PRON
admet-291	75	38	103	103	NUM
admet-291	75	39	about	about	ADV
admet-291	75	40	29	29	NUM
admet-291	75	41	å	å	PROPN
admet-291	75	42	2	2	NUM
admet-291	75	43	to	to	ADP
admet-291	75	44	224	224	NUM
admet-291	75	45	å	å	PROPN
admet-291	75	46	2	2	NUM
admet-291	75	47	with	with	ADP
admet-291	75	48	a	a	DET
admet-291	75	49	median	median	ADJ
admet-291	75	50	value	value	NOUN
admet-291	75	51	of	of	ADP
admet-291	75	52	118.25	118.25	NUM
admet-291	75	53	å	å	PROPN
admet-291	75	54	2	2	NUM
admet-291	75	55	for	for	ADP
admet-291	75	56	the	the	DET
admet-291	75	57	drug	drug	NOUN
admet-291	75	58	set	set	NOUN
admet-291	75	59	,	,	PUNCT
admet-291	75	60	while	while	SCONJ
admet-291	75	61	the	the	DET
admet-291	75	62	polar	polar	ADJ
admet-291	75	63	surface	surface	NOUN
admet-291	75	64	area	area	NOUN
admet-291	75	65	(	(	PUNCT
admet-291	75	66	tpsa	tpsa	PROPN
admet-291	75	67	)	)	PUNCT
admet-291	75	68	for	for	ADP
admet-291	75	69	lead	lead	ADJ
admet-291	75	70	molecules	molecule	NOUN
admet-291	75	71	span	span	VERB
admet-291	75	72	from	from	ADP
admet-291	75	73	0	0	NUM
admet-291	75	74	å	å	PROPN
admet-291	75	75	2	2	NUM
admet-291	75	76	to	to	ADP
admet-291	75	77	266	266	NUM
admet-291	75	78	å	å	PROPN
admet-291	75	79	2	2	NUM
admet-291	75	80	.	.	PUNCT
admet-291	76	1	there	there	PRON
admet-291	76	2	was	be	VERB
admet-291	76	3	a	a	DET
admet-291	76	4	significant	significant	ADJ
admet-291	76	5	difference	difference	NOUN
admet-291	76	6	in	in	ADP
admet-291	76	7	the	the	DET
admet-291	76	8	tpsa	tpsa	NOUN
admet-291	76	9	values	value	NOUN
admet-291	76	10	between	between	ADP
admet-291	76	11	lead	lead	ADJ
admet-291	76	12	candidates	candidate	NOUN
admet-291	76	13	and	and	CCONJ
admet-291	76	14	drugs	drug	NOUN
admet-291	76	15	,	,	PUNCT
admet-291	76	16	almost	almost	ADV
admet-291	76	17	~60	~60	ADP
admet-291	76	18	%	%	NOUN
admet-291	76	19	of	of	ADP
admet-291	76	20	the	the	DET
admet-291	76	21	lead	lead	ADJ
admet-291	76	22	candidates	candidate	NOUN
admet-291	76	23	having	have	VERB
admet-291	76	24	tpsa	tpsa	ADP
admet-291	76	25	<	<	X
admet-291	76	26	80	80	NUM
admet-291	76	27	å2	å2	NOUN
admet-291	76	28	,	,	PUNCT
admet-291	76	29	oppositely	oppositely	ADV
admet-291	76	30	75	75	NUM
admet-291	76	31	%	%	NOUN
admet-291	76	32	drugs	drug	NOUN
admet-291	76	33	have	have	VERB
admet-291	76	34	tpsa	tpsa	NOUN
admet-291	76	35	≥	≥	NUM
admet-291	76	36	80	80	NUM
admet-291	76	37	å	å	PROPN
admet-291	76	38	2	2	NUM
admet-291	76	39	,	,	PUNCT
admet-291	76	40	which	which	PRON
admet-291	76	41	clearly	clearly	ADV
admet-291	76	42	suggests	suggest	VERB
admet-291	76	43	there	there	PRON
admet-291	76	44	is	be	VERB
admet-291	76	45	a	a	DET
admet-291	76	46	huge	huge	ADJ
admet-291	76	47	need	need	NOUN
admet-291	76	48	for	for	ADP
admet-291	76	49	the	the	DET
admet-291	76	50	optimization	optimization	NOUN
admet-291	76	51	of	of	ADP
admet-291	76	52	tpsa	tpsa	NOUN
admet-291	76	53	of	of	ADP
admet-291	76	54	lead	lead	ADJ
admet-291	76	55	candidates	candidate	NOUN
admet-291	76	56	.	.	PUNCT
admet-291	77	1	the	the	DET
admet-291	77	2	drugs	drug	NOUN
admet-291	77	3	and	and	CCONJ
admet-291	77	4	the	the	DET
admet-291	77	5	lead	lead	ADJ
admet-291	77	6	candidates	candidate	NOUN
admet-291	77	7	had	have	VERB
admet-291	77	8	a	a	DET
admet-291	77	9	minimal	minimal	ADJ
admet-291	77	10	number	number	NOUN
admet-291	77	11	of	of	ADP
admet-291	77	12	hydrogen	hydrogen	NOUN
admet-291	77	13	bond	bond	NOUN
admet-291	77	14	donors	donor	NOUN
admet-291	77	15	(	(	PUNCT
admet-291	77	16	hbd	hbd	PROPN
admet-291	77	17	)	)	PUNCT
admet-291	77	18	,	,	PUNCT
admet-291	77	19	with	with	ADP
admet-291	77	20	the	the	DET
admet-291	77	21	median	median	ADJ
admet-291	77	22	value	value	NOUN
admet-291	77	23	of	of	ADP
admet-291	77	24	2	2	NUM
admet-291	77	25	for	for	ADP
admet-291	77	26	both	both	DET
admet-291	77	27	sets	set	NOUN
admet-291	77	28	.	.	PUNCT
admet-291	78	1	almost	almost	ADV
admet-291	78	2	~78	~78	PUNCT
admet-291	78	3	%	%	NOUN
admet-291	78	4	of	of	ADP
admet-291	78	5	lead	lead	ADJ
admet-291	78	6	candidates	candidate	NOUN
admet-291	78	7	and	and	CCONJ
admet-291	78	8	83	83	NUM
admet-291	78	9	%	%	NOUN
admet-291	78	10	of	of	ADP
admet-291	78	11	drugs	drug	NOUN
admet-291	78	12	having	have	VERB
admet-291	78	13	the	the	DET
admet-291	78	14	hbd	hbd	NOUN
admet-291	78	15	value	value	NOUN
admet-291	78	16	≤	≤	ADV
admet-291	78	17	3	3	NUM
admet-291	78	18	.	.	PUNCT
admet-291	79	1	lipinski	lipinski	PROPN
admet-291	79	2	’s	’s	PART
admet-291	79	3	ro5	ro5	PROPN
admet-291	79	4	identified	identify	VERB
admet-291	79	5	hbd	hbd	NOUN
admet-291	79	6	as	as	ADP
admet-291	79	7	a	a	DET
admet-291	79	8	critical	critical	ADJ
admet-291	79	9	component	component	NOUN
admet-291	79	10	of	of	ADP
admet-291	79	11	the	the	DET
admet-291	79	12	drug	drug	NOUN
admet-291	79	13	property	property	NOUN
admet-291	79	14	analysis	analysis	NOUN
admet-291	79	15	and	and	CCONJ
admet-291	79	16	targets	target	VERB
admet-291	79	17	a	a	DET
admet-291	79	18	hbd	hbd	NOUN
admet-291	79	19	count	count	NOUN
admet-291	79	20	(	(	PUNCT
admet-291	79	21	oh	oh	INTJ
admet-291	79	22	plus	plus	CCONJ
admet-291	79	23	nh	nh	PROPN
admet-291	79	24	count	count	NOUN
admet-291	79	25	)	)	PUNCT
admet-291	79	26	of	of	ADP
admet-291	79	27	<	<	X
admet-291	79	28	5	5	NUM
admet-291	79	29	.	.	PUNCT
admet-291	79	30	based	base	VERB
admet-291	79	31	on	on	ADP
admet-291	79	32	the	the	DET
admet-291	79	33	number	number	NOUN
admet-291	79	34	of	of	ADP
admet-291	79	35	hbd	hbd	NOUN
admet-291	79	36	associated	associate	VERB
admet-291	79	37	with	with	ADP
admet-291	79	38	anticancer	anticancer	NOUN
admet-291	79	39	drugs	drug	NOUN
admet-291	79	40	and	and	CCONJ
admet-291	79	41	lead	lead	ADJ
admet-291	79	42	candidates	candidate	NOUN
admet-291	79	43	,	,	PUNCT
admet-291	79	44	optimization	optimization	NOUN
admet-291	79	45	of	of	ADP
admet-291	79	46	hbd	hbd	NOUN
admet-291	79	47	to	to	ADP
admet-291	79	48	≤	≤	NUM
admet-291	79	49	3	3	NUM
admet-291	79	50	may	may	AUX
admet-291	79	51	increase	increase	VERB
admet-291	79	52	the	the	DET
admet-291	79	53	probability	probability	NOUN
admet-291	79	54	of	of	ADP
admet-291	79	55	identifying	identify	VERB
admet-291	79	56	better	well	ADJ
admet-291	79	57	anticancer	anticancer	NOUN
admet-291	79	58	molecules	molecule	NOUN
admet-291	79	59	.	.	PUNCT
admet-291	80	1	figure	figure	NOUN
admet-291	80	2	3	3	NUM
admet-291	80	3	.	.	PUNCT
admet-291	80	4	physicochemical	physicochemical	ADJ
admet-291	80	5	property	property	NOUN
admet-291	80	6	distribution	distribution	NOUN
admet-291	80	7	and	and	CCONJ
admet-291	80	8	statistics	statistic	NOUN
admet-291	80	9	of	of	ADP
admet-291	80	10	drugs	drug	NOUN
admet-291	80	11	and	and	CCONJ
admet-291	80	12	lead	lead	ADJ
admet-291	80	13	candidates	candidate	NOUN
admet-291	80	14	are	be	AUX
admet-291	80	15	shown	show	VERB
admet-291	80	16	for	for	ADP
admet-291	80	17	mw	mw	PROPN
admet-291	80	18	,	,	PUNCT
admet-291	80	19	log	log	VERB
admet-291	80	20	p	p	NOUN
admet-291	80	21	,	,	PUNCT
admet-291	80	22	log	log	PROPN
admet-291	80	23	s	s	PART
admet-291	80	24	,	,	PUNCT
admet-291	80	25	hba	hba	NOUN
admet-291	80	26	,	,	PUNCT
admet-291	80	27	hbd	hbd	NOUN
admet-291	80	28	,	,	PUNCT
admet-291	80	29	tpsa	tpsa	PROPN
admet-291	80	30	,	,	PUNCT
admet-291	80	31	nrot	nrot	PROPN
admet-291	80	32	and	and	CCONJ
admet-291	80	33	log	log	VERB
admet-291	80	34	d.	d.	PROPN
admet-291	80	35	hydrogen	hydrogen	PROPN
admet-291	80	36	bond	bond	NOUN
admet-291	80	37	acceptor	acceptor	NOUN
admet-291	80	38	is	be	AUX
admet-291	80	39	another	another	DET
admet-291	80	40	valuable	valuable	ADJ
admet-291	80	41	physicochemical	physicochemical	ADJ
admet-291	80	42	property	property	NOUN
admet-291	80	43	in	in	ADP
admet-291	80	44	ro5	ro5	NOUN
admet-291	80	45	,	,	PUNCT
admet-291	80	46	drugs	drug	NOUN
admet-291	80	47	and	and	CCONJ
admet-291	80	48	the	the	DET
admet-291	80	49	lead	lead	ADJ
admet-291	80	50	candidates	candidate	NOUN
admet-291	80	51	having	have	VERB
admet-291	80	52	the	the	DET
admet-291	80	53	median	median	ADJ
admet-291	80	54	value	value	NOUN
admet-291	80	55	of	of	ADP
admet-291	80	56	10	10	NUM
admet-291	80	57	and	and	CCONJ
admet-291	80	58	4	4	NUM
admet-291	80	59	respectively	respectively	ADV
admet-291	80	60	.	.	PUNCT
admet-291	81	1	only	only	ADV
admet-291	81	2	11	11	NUM
admet-291	81	3	out	out	ADP
admet-291	81	4	of	of	ADP
admet-291	81	5	24	24	NUM
admet-291	81	6	drugs	drug	NOUN
admet-291	81	7	in	in	ADP
admet-291	81	8	this	this	DET
admet-291	81	9	study	study	NOUN
admet-291	81	10	are	be	AUX
admet-291	81	11	following	follow	VERB
admet-291	81	12	the	the	DET
admet-291	81	13	hba	hba	NOUN
admet-291	81	14	<	<	X
admet-291	81	15	10	10	NUM
admet-291	81	16	rule	rule	NOUN
admet-291	81	17	of	of	ADP
admet-291	81	18	lipinski	lipinski	PROPN
admet-291	81	19	,	,	PUNCT
admet-291	81	20	on	on	ADP
admet-291	81	21	the	the	DET
admet-291	81	22	other	other	ADJ
admet-291	81	23	hand	hand	NOUN
admet-291	81	24	,	,	PUNCT
admet-291	81	25	most	most	ADJ
admet-291	81	26	of	of	ADP
admet-291	81	27	the	the	DET
admet-291	81	28	lead	lead	ADJ
admet-291	81	29	candidates	candidate	NOUN
admet-291	81	30	~89	~89	X
admet-291	81	31	%	%	INTJ
admet-291	81	32	having	have	VERB
admet-291	81	33	the	the	DET
admet-291	81	34	hba	hba	NOUN
admet-291	81	35	<	<	X
admet-291	81	36	10	10	NUM
admet-291	81	37	,	,	PUNCT
admet-291	81	38	so	so	ADV
admet-291	81	39	anticancer	anticancer	NOUN
admet-291	81	40	lead	lead	NOUN
admet-291	81	41	candidates	candidate	NOUN
admet-291	81	42	well	well	ADV
admet-291	81	43	following	follow	VERB
admet-291	81	44	this	this	DET
admet-291	81	45	ro5	ro5	ADJ
admet-291	81	46	compare	compare	NOUN
admet-291	81	47	to	to	ADP
admet-291	81	48	anticancer	anticancer	NOUN
admet-291	81	49	drugs	drug	NOUN
admet-291	81	50	.	.	PUNCT
admet-291	82	1	aqueous	aqueous	PROPN
admet-291	82	2	deepika	deepika	PROPN
admet-291	82	3	singh	singh	PROPN
admet-291	82	4	admet	admet	PROPN
admet-291	82	5	&	&	CCONJ
admet-291	82	6	dmpk	dmpk	PROPN
admet-291	82	7	4(2	4(2	NUM
admet-291	82	8	)	)	PUNCT
admet-291	82	9	(	(	PUNCT
admet-291	82	10	2016	2016	NUM
admet-291	82	11	)	)	PUNCT
admet-291	82	12	98	98	NUM
admet-291	82	13	-	-	SYM
admet-291	82	14	113	113	NUM
admet-291	82	15	104	104	NUM
admet-291	82	16	solubility	solubility	NOUN
admet-291	82	17	is	be	AUX
admet-291	82	18	another	another	DET
admet-291	82	19	very	very	ADV
admet-291	82	20	important	important	ADJ
admet-291	82	21	parameter	parameter	NOUN
admet-291	82	22	for	for	ADP
admet-291	82	23	the	the	DET
admet-291	82	24	oral	oral	ADJ
admet-291	82	25	bioavailability	bioavailability	NOUN
admet-291	82	26	.	.	PUNCT
admet-291	83	1	the	the	DET
admet-291	83	2	recommended	recommend	VERB
admet-291	83	3	range	range	NOUN
admet-291	83	4	for	for	SCONJ
admet-291	83	5	a	a	DET
admet-291	83	6	molecule	molecule	NOUN
admet-291	83	7	to	to	PART
admet-291	83	8	be	be	AUX
admet-291	83	9	good	good	ADJ
admet-291	83	10	oral	oral	ADJ
admet-291	83	11	bioavailable	bioavailable	NOUN
admet-291	83	12	is	be	AUX
admet-291	83	13	(	(	PUNCT
admet-291	83	14	-6	-6	PROPN
admet-291	83	15	≤	≤	NUM
admet-291	83	16	log	log	NOUN
admet-291	83	17	s	s	NOUN
admet-291	83	18	≤	≤	NUM
admet-291	83	19	0.5	0.5	NUM
admet-291	83	20	)	)	PUNCT
admet-291	83	21	,	,	PUNCT
admet-291	83	22	here	here	ADV
admet-291	83	23	all	all	DET
admet-291	83	24	drugs	drug	NOUN
admet-291	83	25	are	be	AUX
admet-291	83	26	following	follow	VERB
admet-291	83	27	this	this	DET
admet-291	83	28	rule	rule	NOUN
admet-291	83	29	and	and	CCONJ
admet-291	83	30	almost	almost	ADV
admet-291	83	31	~95	~95	NUM
admet-291	83	32	%	%	NOUN
admet-291	83	33	of	of	ADP
admet-291	83	34	lead	lead	ADJ
admet-291	83	35	candidates	candidate	NOUN
admet-291	83	36	are	be	AUX
admet-291	83	37	also	also	ADV
admet-291	83	38	falling	fall	VERB
admet-291	83	39	within	within	ADP
admet-291	83	40	the	the	DET
admet-291	83	41	recommended	recommended	ADJ
admet-291	83	42	range	range	NOUN
admet-291	83	43	.	.	PUNCT
admet-291	84	1	the	the	DET
admet-291	84	2	majority	majority	NOUN
admet-291	84	3	of	of	ADP
admet-291	84	4	this	this	DET
admet-291	84	5	increased	increase	VERB
admet-291	84	6	tpsa	tpsa	NOUN
admet-291	84	7	should	should	AUX
admet-291	84	8	originate	originate	VERB
admet-291	84	9	from	from	ADP
admet-291	84	10	an	an	DET
admet-291	84	11	increased	increase	VERB
admet-291	84	12	number	number	NOUN
admet-291	84	13	of	of	ADP
admet-291	84	14	hba	hba	NOUN
admet-291	84	15	,	,	PUNCT
admet-291	84	16	as	as	SCONJ
admet-291	84	17	hbd	hbd	NOUN
admet-291	84	18	must	must	AUX
admet-291	84	19	be	be	AUX
admet-291	84	20	strictly	strictly	ADV
admet-291	84	21	controlled	control	VERB
admet-291	84	22	at	at	ADP
admet-291	84	23	≤	≤	NUM
admet-291	84	24	6	6	NUM
admet-291	84	25	to	to	PART
admet-291	84	26	avoid	avoid	VERB
admet-291	84	27	reducing	reduce	VERB
admet-291	84	28	oral	oral	ADJ
admet-291	84	29	bioavailability	bioavailability	NOUN
admet-291	84	30	.	.	PUNCT
admet-291	85	1	log	log	PROPN
admet-291	85	2	d	d	PROPN
admet-291	85	3	provides	provide	VERB
admet-291	85	4	a	a	DET
admet-291	85	5	better	well	ADJ
admet-291	85	6	measurement	measurement	NOUN
admet-291	85	7	of	of	ADP
admet-291	85	8	lipophilicity	lipophilicity	NOUN
admet-291	85	9	for	for	ADP
admet-291	85	10	ionizable	ionizable	ADJ
admet-291	85	11	compounds	compound	NOUN
admet-291	85	12	;	;	PUNCT
admet-291	85	13	we	we	PRON
admet-291	85	14	know	know	VERB
admet-291	85	15	that	that	SCONJ
admet-291	85	16	hydrophilic	hydrophilic	ADJ
admet-291	85	17	molecules	molecule	NOUN
admet-291	85	18	have	have	VERB
admet-291	85	19	higher	high	ADJ
admet-291	85	20	solubility	solubility	NOUN
admet-291	85	21	,	,	PUNCT
admet-291	85	22	but	but	CCONJ
admet-291	85	23	are	be	AUX
admet-291	85	24	less	less	ADV
admet-291	85	25	equipped	equipped	ADJ
admet-291	85	26	to	to	PART
admet-291	85	27	readily	readily	ADV
admet-291	85	28	cross	cross	VERB
admet-291	85	29	the	the	DET
admet-291	85	30	cell	cell	NOUN
admet-291	85	31	membrane	membrane	NOUN
admet-291	85	32	.	.	PUNCT
admet-291	86	1	hence	hence	ADV
admet-291	86	2	,	,	PUNCT
admet-291	86	3	a	a	DET
admet-291	86	4	compound	compound	NOUN
admet-291	86	5	is	be	AUX
admet-291	86	6	considered	consider	VERB
admet-291	86	7	to	to	PART
admet-291	86	8	be	be	AUX
admet-291	86	9	hydrophilic	hydrophilic	ADJ
admet-291	86	10	,	,	PUNCT
admet-291	86	11	if	if	SCONJ
admet-291	86	12	log	log	VERB
admet-291	86	13	d	d	X
admet-291	86	14	<	<	X
admet-291	86	15	0	0	PROPN
admet-291	86	16	,	,	PUNCT
admet-291	86	17	lipophilic	lipophilic	ADJ
admet-291	86	18	if	if	SCONJ
admet-291	86	19	log	log	VERB
admet-291	86	20	d	d	X
admet-291	86	21	>	>	X
admet-291	86	22	0	0	NUM
admet-291	86	23	,	,	PUNCT
admet-291	86	24	and	and	CCONJ
admet-291	86	25	molecule	molecule	NOUN
admet-291	86	26	excessive	excessive	ADJ
admet-291	86	27	lipophilic	lipophilic	NOUN
admet-291	86	28	by	by	ADP
admet-291	86	29	molecules	molecule	NOUN
admet-291	86	30	with	with	ADP
admet-291	86	31	log	log	PROPN
admet-291	86	32	d	d	PROPN
admet-291	86	33	≥	≥	NUM
admet-291	86	34	3.5	3.5	NUM
admet-291	86	35	.	.	PUNCT
admet-291	87	1	nearly	nearly	ADV
admet-291	87	2	~85	~85	NOUN
admet-291	87	3	%	%	NOUN
admet-291	87	4	of	of	ADP
admet-291	87	5	the	the	DET
admet-291	87	6	lead	lead	ADJ
admet-291	87	7	candidates	candidate	NOUN
admet-291	87	8	having	have	VERB
admet-291	87	9	a	a	DET
admet-291	87	10	log	log	NOUN
admet-291	87	11	d	d	NOUN
admet-291	87	12	value	value	NOUN
admet-291	87	13	from	from	ADP
admet-291	87	14	1	1	NUM
admet-291	87	15	to	to	PART
admet-291	87	16	8	8	NUM
admet-291	87	17	(	(	PUNCT
admet-291	87	18	1	1	NUM
admet-291	87	19	≤	≤	NUM
admet-291	87	20	log	log	NOUN
admet-291	87	21	d	d	NOUN
admet-291	87	22	≤	≤	ADJ
admet-291	87	23	8)	8)	NUM
admet-291	87	24	,	,	PUNCT
admet-291	87	25	with	with	ADP
admet-291	87	26	a	a	DET
admet-291	87	27	median	median	NOUN
admet-291	87	28	of	of	ADP
admet-291	87	29	3.15	3.15	NUM
admet-291	87	30	,	,	PUNCT
admet-291	87	31	which	which	PRON
admet-291	87	32	suggest	suggest	VERB
admet-291	87	33	maximum	maximum	ADJ
admet-291	87	34	lead	lead	ADJ
admet-291	87	35	candidates	candidate	NOUN
admet-291	87	36	are	be	AUX
admet-291	87	37	hydrophobic	hydrophobic	ADJ
admet-291	87	38	in	in	ADP
admet-291	87	39	nature	nature	NOUN
admet-291	87	40	.	.	PUNCT
admet-291	88	1	as	as	SCONJ
admet-291	88	2	expected	expect	VERB
admet-291	88	3	for	for	ADP
admet-291	88	4	anticancer	anticancer	NOUN
admet-291	88	5	drugs	drug	NOUN
admet-291	88	6	,	,	PUNCT
admet-291	88	7	a	a	DET
admet-291	88	8	similar	similar	ADJ
admet-291	88	9	but	but	CCONJ
admet-291	88	10	narrower	narrow	ADJ
admet-291	88	11	range	range	NOUN
admet-291	88	12	existed	exist	VERB
admet-291	88	13	for	for	ADP
admet-291	88	14	log	log	NOUN
admet-291	88	15	d	d	PROPN
admet-291	88	16	,	,	PUNCT
admet-291	88	17	which	which	PRON
admet-291	88	18	varied	vary	VERB
admet-291	88	19	from	from	ADP
admet-291	88	20	-0.86	-0.86	INTJ
admet-291	88	21	to	to	ADP
admet-291	88	22	4.88	4.88	NUM
admet-291	88	23	with	with	ADP
admet-291	88	24	a	a	DET
admet-291	88	25	median	median	ADJ
admet-291	88	26	value	value	NOUN
admet-291	88	27	of	of	ADP
admet-291	88	28	2.57	2.57	NUM
admet-291	88	29	.	.	PUNCT
admet-291	89	1	in	in	ADP
admet-291	89	2	order	order	NOUN
admet-291	89	3	to	to	PART
admet-291	89	4	accurately	accurately	ADV
admet-291	89	5	access	access	VERB
admet-291	89	6	the	the	DET
admet-291	89	7	differences	difference	NOUN
admet-291	89	8	between	between	ADP
admet-291	89	9	anticancer	anticancer	NOUN
admet-291	89	10	drugs	drug	NOUN
admet-291	89	11	and	and	CCONJ
admet-291	89	12	leads	lead	NOUN
admet-291	89	13	,	,	PUNCT
admet-291	89	14	four	four	NUM
admet-291	89	15	drug	drug	NOUN
admet-291	89	16	-	-	PUNCT
admet-291	89	17	like	like	ADJ
admet-291	89	18	indices	index	NOUN
admet-291	89	19	were	be	AUX
admet-291	89	20	utilized	utilize	VERB
admet-291	89	21	for	for	ADP
admet-291	89	22	comparison	comparison	NOUN
admet-291	89	23	;	;	PUNCT
admet-291	89	24	lipinski	lipinski	PROPN
admet-291	89	25	’s	’s	PART
admet-291	89	26	ro5	ro5	PROPN
admet-291	89	27	,	,	PUNCT
admet-291	89	28	ghose	ghose	PROPN
admet-291	89	29	filter	filter	PROPN
admet-291	89	30	,	,	PUNCT
admet-291	89	31	vebers	veber	NOUN
admet-291	89	32	’s	’s	PART
admet-291	89	33	selective	selective	ADJ
admet-291	89	34	criteria	criterion	NOUN
admet-291	89	35	for	for	ADP
admet-291	89	36	oral	oral	ADJ
admet-291	89	37	bioavailable	bioavailable	ADJ
admet-291	89	38	drugs	drug	NOUN
admet-291	89	39	,	,	PUNCT
admet-291	89	40	and	and	CCONJ
admet-291	89	41	qed	qed	PROPN
admet-291	89	42	by	by	ADP
admet-291	89	43	drulito	drulito	PROPN
admet-291	89	44	.	.	PUNCT
admet-291	90	1	the	the	DET
admet-291	90	2	detailed	detailed	ADJ
admet-291	90	3	results	result	NOUN
admet-291	90	4	in	in	ADP
admet-291	90	5	percentage	percentage	NOUN
admet-291	90	6	(	(	PUNCT
admet-291	90	7	%	%	NOUN
admet-291	90	8	)	)	PUNCT
admet-291	90	9	of	of	ADP
admet-291	90	10	lead	lead	NOUN
admet-291	90	11	and	and	CCONJ
admet-291	90	12	drug	drug	NOUN
admet-291	90	13	molecules	molecule	NOUN
admet-291	90	14	are	be	AUX
admet-291	90	15	following	follow	VERB
admet-291	90	16	and	and	CCONJ
admet-291	90	17	violating	violate	VERB
admet-291	90	18	the	the	DET
admet-291	90	19	above	above	NOUN
admet-291	90	20	mentioned	mention	VERB
admet-291	90	21	most	most	ADV
admet-291	90	22	promising	promising	ADJ
admet-291	90	23	oral	oral	ADJ
admet-291	90	24	bioavailable	bioavailable	ADJ
admet-291	90	25	rules	rule	NOUN
admet-291	90	26	are	be	AUX
admet-291	90	27	mentioned	mention	VERB
admet-291	90	28	in	in	ADP
admet-291	90	29	the	the	DET
admet-291	90	30	figure	figure	NOUN
admet-291	90	31	4(a	4(a	NUM
admet-291	90	32	)	)	PUNCT
admet-291	90	33	and	and	CCONJ
admet-291	90	34	figure	figure	VERB
admet-291	90	35	4(b	4(b	NUM
admet-291	90	36	)	)	PUNCT
admet-291	90	37	respectively	respectively	ADV
admet-291	90	38	.	.	PUNCT
admet-291	91	1	figure	figure	NOUN
admet-291	91	2	4	4	NUM
admet-291	91	3	.	.	PUNCT
admet-291	91	4	bar	bar	NOUN
admet-291	91	5	graph	graph	NOUN
admet-291	91	6	for	for	ADP
admet-291	91	7	percentage	percentage	NOUN
admet-291	91	8	(	(	PUNCT
admet-291	91	9	%	%	NOUN
admet-291	91	10	)	)	PUNCT
admet-291	91	11	of	of	ADP
admet-291	91	12	lead	lead	NOUN
admet-291	91	13	and	and	CCONJ
admet-291	91	14	drug	drug	NOUN
admet-291	91	15	molecules	molecule	NOUN
admet-291	91	16	are	be	AUX
admet-291	91	17	(	(	PUNCT
admet-291	91	18	a	a	NOUN
admet-291	91	19	)	)	PUNCT
admet-291	91	20	following	following	NOUN
admet-291	91	21	,	,	PUNCT
admet-291	91	22	and	and	CCONJ
admet-291	91	23	(	(	PUNCT
admet-291	91	24	b	b	NOUN
admet-291	91	25	)	)	PUNCT
admet-291	91	26	violating	violate	VERB
admet-291	91	27	the	the	DET
admet-291	91	28	lipinski	lipinski	PROPN
admet-291	91	29	’s	’s	PART
admet-291	91	30	ro5	ro5	PROPN
admet-291	91	31	,	,	PUNCT
admet-291	91	32	ghose	ghose	PROPN
admet-291	91	33	filter	filter	PROPN
admet-291	91	34	,	,	PUNCT
admet-291	91	35	vebers	veber	NOUN
admet-291	91	36	’s	’s	PART
admet-291	91	37	rule	rule	NOUN
admet-291	91	38	,	,	PUNCT
admet-291	91	39	qed	qed	PROPN
admet-291	91	40	,	,	PUNCT
admet-291	91	41	and	and	CCONJ
admet-291	91	42	all	all	DET
admet-291	91	43	selected	select	VERB
admet-291	91	44	filters	filter	NOUN
admet-291	91	45	.	.	PUNCT
admet-291	92	1	the	the	DET
admet-291	92	2	inspection	inspection	NOUN
admet-291	92	3	of	of	ADP
admet-291	92	4	the	the	DET
admet-291	92	5	bar	bar	NOUN
admet-291	92	6	graph	graph	NOUN
admet-291	92	7	shown	show	VERB
admet-291	92	8	in	in	ADP
admet-291	92	9	figure	figure	NOUN
admet-291	92	10	4(a	4(a	NUM
admet-291	92	11	)	)	PUNCT
admet-291	92	12	reveals	reveal	VERB
admet-291	92	13	that	that	PRON
admet-291	92	14	leads	lead	VERB
admet-291	92	15	are	be	AUX
admet-291	92	16	following	follow	VERB
admet-291	92	17	most	most	ADJ
admet-291	92	18	of	of	ADP
admet-291	92	19	the	the	DET
admet-291	92	20	bioavailable	bioavailable	ADJ
admet-291	92	21	rules	rule	NOUN
admet-291	92	22	greater	great	ADJ
admet-291	92	23	than	than	ADP
admet-291	92	24	the	the	DET
admet-291	92	25	drugs	drug	NOUN
admet-291	92	26	except	except	SCONJ
admet-291	92	27	the	the	DET
admet-291	92	28	ghose	ghose	PROPN
admet-291	92	29	filter	filter	PROPN
admet-291	92	30	.	.	PUNCT
admet-291	93	1	drugs	drug	NOUN
admet-291	93	2	and	and	CCONJ
admet-291	93	3	leads	lead	NOUN
admet-291	93	4	are	be	AUX
admet-291	93	5	showing	show	VERB
admet-291	93	6	almost	almost	ADV
admet-291	93	7	equal	equal	ADJ
admet-291	93	8	percentage	percentage	NOUN
admet-291	93	9	of	of	ADP
admet-291	93	10	molecules	molecule	NOUN
admet-291	93	11	~38	~38	NUM
admet-291	93	12	%	%	NOUN
admet-291	93	13	following	follow	VERB
admet-291	93	14	the	the	DET
admet-291	93	15	all	all	DET
admet-291	93	16	selected	select	VERB
admet-291	93	17	filters	filter	NOUN
admet-291	93	18	,	,	PUNCT
admet-291	93	19	which	which	PRON
admet-291	93	20	is	be	AUX
admet-291	93	21	obtained	obtain	VERB
admet-291	93	22	by	by	ADP
admet-291	93	23	considering	consider	VERB
admet-291	93	24	all	all	DET
admet-291	93	25	4	4	NUM
admet-291	93	26	bioavailable	bioavailable	ADJ
admet-291	93	27	,	,	PUNCT
admet-291	93	28	filters	filter	NOUN
admet-291	93	29	(	(	PUNCT
admet-291	93	30	lipinski	lipinski	PROPN
admet-291	93	31	’s	’s	PART
admet-291	93	32	ro5	ro5	PROPN
admet-291	93	33	,	,	PUNCT
admet-291	93	34	ghose	ghose	PROPN
admet-291	93	35	filter	filter	PROPN
admet-291	93	36	,	,	PUNCT
admet-291	93	37	vebers	veber	NOUN
admet-291	93	38	’s	’s	PART
admet-291	93	39	rule	rule	NOUN
admet-291	93	40	,	,	PUNCT
admet-291	93	41	and	and	CCONJ
admet-291	93	42	qed	qed	PROPN
admet-291	93	43	)	)	PUNCT
admet-291	93	44	together	together	ADV
admet-291	93	45	.	.	PUNCT
admet-291	94	1	similarly	similarly	ADV
admet-291	94	2	,	,	PUNCT
admet-291	94	3	greater	great	ADJ
admet-291	94	4	percentage	percentage	NOUN
admet-291	94	5	of	of	ADP
admet-291	94	6	drugs	drug	NOUN
admet-291	94	7	are	be	AUX
admet-291	94	8	violating	violate	VERB
admet-291	94	9	the	the	DET
admet-291	94	10	bioavailable	bioavailable	ADJ
admet-291	94	11	rules	rule	NOUN
admet-291	94	12	except	except	SCONJ
admet-291	94	13	the	the	DET
admet-291	94	14	ghose	ghose	PROPN
admet-291	94	15	filter	filter	PROPN
admet-291	94	16	.	.	PUNCT
admet-291	95	1	while	while	SCONJ
admet-291	95	2	the	the	DET
admet-291	95	3	natural	natural	ADJ
admet-291	95	4	product	product	NOUN
admet-291	95	5	derived	derive	VERB
admet-291	95	6	anticancer	anticancer	NOUN
admet-291	95	7	drug	drug	NOUN
admet-291	95	8	space	space	NOUN
admet-291	95	9	as	as	SCONJ
admet-291	95	10	defined	define	VERB
admet-291	95	11	by	by	ADP
admet-291	95	12	mw	mw	NOUN
admet-291	95	13	,	,	PUNCT
admet-291	95	14	log	log	VERB
admet-291	95	15	p	p	NOUN
admet-291	95	16	,	,	PUNCT
admet-291	95	17	log	log	PROPN
admet-291	95	18	s	s	PART
admet-291	95	19	,	,	PUNCT
admet-291	95	20	hba	hba	NOUN
admet-291	95	21	,	,	PUNCT
admet-291	95	22	hbd	hbd	NOUN
admet-291	95	23	,	,	PUNCT
admet-291	95	24	tpsa	tpsa	PROPN
admet-291	95	25	,	,	PUNCT
admet-291	95	26	nrot	nrot	NOUN
admet-291	95	27	and	and	CCONJ
admet-291	95	28	log	log	VERB
admet-291	95	29	d	d	NOUN
admet-291	95	30	,	,	PUNCT
admet-291	95	31	is	be	AUX
admet-291	95	32	broad	broad	ADJ
admet-291	95	33	.	.	PUNCT
admet-291	96	1	hence	hence	ADV
admet-291	96	2	,	,	PUNCT
admet-291	96	3	our	our	PRON
admet-291	96	4	emphasis	emphasis	NOUN
admet-291	96	5	has	have	AUX
admet-291	96	6	been	be	AUX
admet-291	96	7	on	on	ADP
admet-291	96	8	defining	define	VERB
admet-291	96	9	physicochemical	physicochemical	ADJ
admet-291	96	10	property	property	NOUN
admet-291	96	11	rules	rule	NOUN
admet-291	96	12	for	for	ADP
admet-291	96	13	compounds	compound	NOUN
admet-291	96	14	to	to	PART
admet-291	96	15	reduce	reduce	VERB
admet-291	96	16	attrition	attrition	NOUN
admet-291	96	17	and	and	CCONJ
admet-291	96	18	increase	increase	VERB
admet-291	96	19	the	the	DET
admet-291	96	20	likelihood	likelihood	NOUN
admet-291	96	21	of	of	ADP
admet-291	96	22	candidates	candidate	NOUN
admet-291	96	23	at	at	ADP
admet-291	96	24	various	various	ADJ
admet-291	96	25	stages	stage	NOUN
admet-291	96	26	of	of	ADP
admet-291	96	27	anticancer	anticancer	NOUN
admet-291	96	28	drug	drug	NOUN
admet-291	96	29	development	development	NOUN
admet-291	96	30	based	base	VERB
admet-291	96	31	on	on	ADP
admet-291	96	32	our	our	PRON
admet-291	96	33	analysis	analysis	NOUN
admet-291	96	34	as	as	ADV
admet-291	96	35	well	well	ADV
admet-291	96	36	as	as	ADP
admet-291	96	37	earlier	early	ADV
admet-291	96	38	published	publish	VERB
admet-291	96	39	various	various	ADJ
admet-291	96	40	oral	oral	ADJ
admet-291	96	41	bioavailability	bioavailability	NOUN
admet-291	96	42	rules	rule	NOUN
admet-291	96	43	by	by	ADP
admet-291	96	44	different	different	ADJ
admet-291	96	45	research	research	NOUN
admet-291	96	46	groups	group	NOUN
admet-291	96	47	.	.	PUNCT
admet-291	97	1	our	our	PRON
admet-291	97	2	analysis	analysis	NOUN
admet-291	97	3	shows	show	VERB
admet-291	97	4	the	the	DET
admet-291	97	5	optimal	optimal	ADJ
admet-291	97	6	property	property	NOUN
admet-291	97	7	ranges	range	NOUN
admet-291	97	8	(	(	PUNCT
admet-291	97	9	covering	cover	VERB
admet-291	97	10	almost	almost	ADV
admet-291	97	11	~80	~80	NOUN
admet-291	97	12	%	%	NOUN
admet-291	97	13	or	or	CCONJ
admet-291	97	14	more	more	ADJ
admet-291	97	15	of	of	ADP
admet-291	97	16	the	the	DET
admet-291	97	17	anticancer	anticancer	NOUN
admet-291	97	18	drugs	drug	NOUN
admet-291	97	19	)	)	PUNCT
admet-291	97	20	used	use	VERB
admet-291	97	21	to	to	PART
admet-291	97	22	select	select	VERB
admet-291	97	23	drug	drug	NOUN
admet-291	97	24	-	-	PUNCT
admet-291	97	25	like	like	ADJ
admet-291	97	26	anticancer	anticancer	NOUN
admet-291	97	27	molecule	molecule	NOUN
admet-291	97	28	for	for	ADP
admet-291	97	29	these	these	DET
admet-291	97	30	properties	property	NOUN
admet-291	97	31	are	be	AUX
admet-291	97	32	200	200	NUM
admet-291	97	33	<	<	X
admet-291	97	34	mw	mw	X
admet-291	97	35	≤	≤	NUM
admet-291	97	36	800	800	NUM
admet-291	97	37	da	da	NOUN
admet-291	97	38	,	,	PUNCT
admet-291	97	39	1	1	NUM
admet-291	97	40	<	<	X
admet-291	97	41	log	log	NOUN
admet-291	97	42	p	p	NOUN
admet-291	97	43	≤	≤	NUM
admet-291	97	44	5	5	NUM
admet-291	97	45	,	,	PUNCT
admet-291	97	46	-6	-6	PROPN
admet-291	97	47	≤	≤	NUM
admet-291	97	48	clog	clog	NOUN
admet-291	97	49	s	s	PART
admet-291	97	50	≤	≤	NOUN
admet-291	97	51	-1	-1	PUNCT
admet-291	97	52	,	,	PUNCT
admet-291	97	53	5	5	NUM
admet-291	97	54	≤	≤	NUM
admet-291	97	55	hba	hba	X
admet-291	97	56	≤	≤	ADV
admet-291	97	57	13	13	NUM
admet-291	97	58	,	,	PUNCT
admet-291	97	59	1	1	NUM
admet-291	97	60	≤	≤	NUM
admet-291	97	61	hbd	hbd	NOUN
admet-291	97	62	≤	≤	ADV
admet-291	97	63	5	5	NUM
admet-291	97	64	,	,	PUNCT
admet-291	97	65	50	50	NUM
admet-291	97	66	≤	≤	NUM
admet-291	97	67	tpsa	tpsa	NOUN
admet-291	97	68	≤	≤	NUM
admet-291	97	69	180	180	NUM
admet-291	97	70	å2	å2	NOUN
admet-291	97	71	,	,	PUNCT
admet-291	97	72	0	0	NUM
admet-291	97	73	≤	≤	NUM
admet-291	97	74	nrot	nrot	NOUN
admet-291	97	75	≤	≤	ADV
admet-291	97	76	10	10	NUM
admet-291	97	77	,	,	PUNCT
admet-291	97	78	log	log	NOUN
admet-291	97	79	d=2.8	d=2.8	PROPN
admet-291	97	80	,	,	PUNCT
admet-291	97	81	which	which	PRON
admet-291	97	82	may	may	AUX
admet-291	97	83	be	be	AUX
admet-291	97	84	very	very	ADV
admet-291	97	85	admet	admet	ADJ
admet-291	97	86	&	&	CCONJ
admet-291	97	87	dmpk	dmpk	PROPN
admet-291	97	88	4(2	4(2	NUM
admet-291	97	89	)	)	PUNCT
admet-291	97	90	(	(	PUNCT
admet-291	97	91	2016	2016	NUM
admet-291	97	92	)	)	PUNCT
admet-291	97	93	98	98	NUM
admet-291	97	94	-	-	SYM
admet-291	97	95	113	113	NUM
admet-291	97	96	defining	define	VERB
admet-291	97	97	natural	natural	ADJ
admet-291	97	98	product	product	NOUN
admet-291	97	99	derived	derive	VERB
admet-291	97	100	anticancer	anticancer	NOUN
admet-291	97	101	drug	drug	NOUN
admet-291	97	102	space	space	NOUN
admet-291	97	103	doi	doi	NOUN
admet-291	97	104	:	:	PUNCT
admet-291	97	105	10.5599	10.5599	NUM
admet-291	97	106	/	/	SYM
admet-291	97	107	admet.4.2.291	admet.4.2.291	PROPN
admet-291	97	108	105	105	NUM
admet-291	97	109	table	table	NOUN
admet-291	97	110	1	1	NUM
admet-291	97	111	.	.	PUNCT
admet-291	98	1	important	important	ADJ
admet-291	98	2	computed	compute	VERB
admet-291	98	3	physicochemical	physicochemical	ADJ
admet-291	98	4	properties	property	NOUN
admet-291	98	5	for	for	ADP
admet-291	98	6	anticancer	anticancer	NOUN
admet-291	98	7	lead	lead	NOUN
admet-291	98	8	candidates	candidate	NOUN
admet-291	98	9	and	and	CCONJ
admet-291	98	10	drugs	drug	NOUN
admet-291	98	11	.	.	PUNCT
admet-291	99	1	lead	lead	NOUN
admet-291	99	2	candidates	candidate	NOUN
admet-291	99	3	mw	mw	AUX
admet-291	99	4	log	log	NOUN
admet-291	99	5	p	p	NOUN
admet-291	100	1	log	log	NOUN
admet-291	100	2	s	s	X
admet-291	100	3	hba	hba	PROPN
admet-291	100	4	hbd	hbd	PROPN
admet-291	100	5	tpsa	tpsa	PROPN
admet-291	100	6	nrot	nrot	PROPN
admet-291	100	7	log	log	VERB
admet-291	100	8	d	d	PROPN
admet-291	100	9	13	13	NUM
admet-291	100	10	-	-	PUNCT
admet-291	100	11	epi	epi	NOUN
admet-291	100	12	-	-	NOUN
admet-291	100	13	sclareol	sclareol	ADJ
admet-291	100	14	611	611	NUM
admet-291	100	15	-1.41	-1.41	NOUN
admet-291	100	16	-2.58	-2.58	NUM
admet-291	100	17	16	16	NUM
admet-291	100	18	10	10	NUM
admet-291	100	19	266	266	NUM
admet-291	100	20	6	6	NUM
admet-291	100	21	-2.42	-2.42	NUM
admet-291	100	22	6	6	NUM
admet-291	100	23	-	-	PUNCT
admet-291	100	24	gingerol	gingerol	VERB
admet-291	100	25	294	294	NUM
admet-291	100	26	3.56	3.56	NUM
admet-291	100	27	-3.25	-3.25	NUM
admet-291	100	28	4	4	NUM
admet-291	100	29	2	2	NUM
admet-291	100	30	67	67	NUM
admet-291	100	31	10	10	NUM
admet-291	100	32	3.64	3.64	NUM
admet-291	100	33	ahwagandhanolide	ahwagandhanolide	ADV
admet-291	100	34	975	975	NUM
admet-291	100	35	5.36	5.36	NUM
admet-291	100	36	-8.25	-8.25	NOUN
admet-291	100	37	12	12	NUM
admet-291	100	38	6	6	NUM
admet-291	100	39	233	233	NUM
admet-291	100	40	8	8	NUM
admet-291	100	41	6.75	6.75	NUM
admet-291	100	42	allicin	allicin	NOUN
admet-291	100	43	162	162	NUM
admet-291	100	44	1.84	1.84	NUM
admet-291	100	45	-1.22	-1.22	NOUN
admet-291	100	46	1	1	NUM
admet-291	100	47	0	0	NUM
admet-291	100	48	62	62	NUM
admet-291	100	49	5	5	NUM
admet-291	100	50	2.01	2.01	NUM
admet-291	100	51	anethol	anethol	NOUN
admet-291	100	52	148	148	NUM
admet-291	100	53	2.68	2.68	NUM
admet-291	100	54	-2.54	-2.54	NUM
admet-291	100	55	1	1	NUM
admet-291	100	56	0	0	NUM
admet-291	100	57	9	9	NUM
admet-291	100	58	2	2	NUM
admet-291	100	59	2.77	2.77	NUM
admet-291	100	60	berberine	berberine	NOUN
admet-291	100	61	336	336	NUM
admet-291	100	62	0.52	0.52	NUM
admet-291	100	63	-4.67	-4.67	NUM
admet-291	100	64	5	5	NUM
admet-291	100	65	0	0	NUM
admet-291	100	66	41	41	NUM
admet-291	100	67	2	2	NUM
admet-291	100	68	3.96	3.96	NUM
admet-291	100	69	beta	beta	NOUN
admet-291	100	70	carotene	carotene	NOUN
admet-291	100	71	537	537	NUM
admet-291	100	72	13.87	13.87	NUM
admet-291	100	73	-7.33	-7.33	NUM
admet-291	100	74	0	0	NUM
admet-291	100	75	0	0	NUM
admet-291	100	76	0	0	NUM
admet-291	100	77	10	10	NUM
admet-291	100	78	12.00	12.00	NUM
admet-291	100	79	betulinic	betulinic	ADJ
admet-291	100	80	acid	acid	NOUN
admet-291	100	81	457	457	NUM
admet-291	100	82	6.37	6.37	NUM
admet-291	100	83	-6.28	-6.28	DET
admet-291	100	84	3	3	NUM
admet-291	100	85	2	2	NUM
admet-291	100	86	58	58	NUM
admet-291	100	87	2	2	NUM
admet-291	100	88	6.52	6.52	NUM
admet-291	100	89	capsaicin	capsaicin	NOUN
admet-291	100	90	305	305	NUM
admet-291	100	91	3.80	3.80	NUM
admet-291	100	92	-3.32	-3.32	NUM
admet-291	100	93	4	4	NUM
admet-291	100	94	2	2	NUM
admet-291	100	95	59	59	NUM
admet-291	100	96	9	9	NUM
admet-291	100	97	3.90	3.90	NUM
admet-291	100	98	catechins	catechin	NOUN
admet-291	100	99	290	290	NUM
admet-291	100	100	1.51	1.51	NUM
admet-291	100	101	-1.76	-1.76	NUM
admet-291	100	102	6	6	NUM
admet-291	100	103	5	5	NUM
admet-291	100	104	110	110	NUM
admet-291	100	105	1	1	NUM
admet-291	100	106	1.90	1.90	NUM
admet-291	100	107	corchorusin	corchorusin	NOUN
admet-291	100	108	-	-	PUNCT
admet-291	100	109	d	d	NOUN
admet-291	100	110	781	781	NUM
admet-291	100	111	1.54	1.54	NUM
admet-291	100	112	-5.21	-5.21	NUM
admet-291	100	113	13	13	NUM
admet-291	100	114	8	8	NUM
admet-291	100	115	208	208	NUM
admet-291	100	116	6	6	NUM
admet-291	100	117	1.31	1.31	NUM
admet-291	100	118	curcumin	curcumin	NOUN
admet-291	100	119	368	368	NUM
admet-291	100	120	2.95	2.95	NUM
admet-291	100	121	-3.62	-3.62	NUM
admet-291	100	122	6	6	NUM
admet-291	100	123	2	2	NUM
admet-291	100	124	93	93	NUM
admet-291	100	125	8	8	NUM
admet-291	100	126	3.55	3.55	NUM
admet-291	100	127	diallyl	diallyl	NOUN
admet-291	100	128	sulfide	sulfide	NOUN
admet-291	100	129	114	114	NUM
admet-291	100	130	2.16	2.16	NUM
admet-291	100	131	-2.01	-2.01	NUM
admet-291	100	132	0	0	NUM
admet-291	100	133	0	0	NUM
admet-291	100	134	25	25	NUM
admet-291	100	135	4	4	NUM
admet-291	100	136	2.03	2.03	NUM
admet-291	100	137	diosgenin	diosgenin	VERB
admet-291	100	138	415	415	NUM
admet-291	100	139	4.88	4.88	NUM
admet-291	100	140	-5.58	-5.58	NUM
admet-291	100	141	3	3	NUM
admet-291	100	142	1	1	NUM
admet-291	100	143	39	39	NUM
admet-291	100	144	0	0	NUM
admet-291	100	145	4.63	4.63	NUM
admet-291	100	146	ellagic	ellagic	ADJ
admet-291	100	147	acid	acid	NOUN
admet-291	100	148	302	302	NUM
admet-291	100	149	1.28	1.28	NUM
admet-291	100	150	-3.29	-3.29	NUM
admet-291	100	151	8	8	NUM
admet-291	100	152	4	4	NUM
admet-291	100	153	134	134	NUM
admet-291	100	154	0	0	NUM
admet-291	100	155	1.29	1.29	NUM
admet-291	100	156	eugenol	eugenol	NOUN
admet-291	100	157	164	164	NUM
admet-291	100	158	2.27	2.27	NUM
admet-291	100	159	-2.05	-2.05	NUM
admet-291	100	160	2	2	NUM
admet-291	100	161	1	1	NUM
admet-291	100	162	29	29	NUM
admet-291	100	163	3	3	NUM
admet-291	100	164	2.58	2.58	NUM
admet-291	100	165	genistein	genistein	NOUN
admet-291	100	166	270	270	NUM
admet-291	100	167	1.63	1.63	NUM
admet-291	100	168	-2.73	-2.73	NUM
admet-291	100	169	5	5	NUM
admet-291	100	170	3	3	NUM
admet-291	100	171	87	87	NUM
admet-291	100	172	1	1	NUM
admet-291	100	173	1.12	1.12	NUM
admet-291	100	174	indole-3	indole-3	NUM
admet-291	100	175	-	-	PUNCT
admet-291	100	176	carbinol	carbinol	NOUN
admet-291	100	177	147	147	NUM
admet-291	100	178	1.10	1.10	NUM
admet-291	100	179	-2.03	-2.03	NUM
admet-291	100	180	2	2	NUM
admet-291	100	181	2	2	NUM
admet-291	100	182	36	36	NUM
admet-291	100	183	1	1	NUM
admet-291	100	184	1.52	1.52	NUM
admet-291	100	185	limonen	limonen	NOUN
admet-291	100	186	136	136	NUM
admet-291	100	187	3.36	3.36	NUM
admet-291	100	188	-2.54	-2.54	NOUN
admet-291	100	189	0	0	NUM
admet-291	100	190	0	0	NUM
admet-291	100	191	0	0	NUM
admet-291	100	192	1	1	NUM
admet-291	100	193	3.50	3.50	NUM
admet-291	100	194	drugs	drug	NOUN
admet-291	100	195	abiraterone	abiraterone	NOUN
admet-291	100	196	392	392	NUM
admet-291	100	197	4.67	4.67	NUM
admet-291	100	198	-4.75	-4.75	NUM
admet-291	100	199	3	3	NUM
admet-291	100	200	0	0	NUM
admet-291	100	201	39	39	NUM
admet-291	100	202	3	3	NUM
admet-291	100	203	4.72	4.72	NUM
admet-291	100	204	amrubicin	amrubicin	NOUN
admet-291	100	205	483	483	NUM
admet-291	100	206	0.84	0.84	NUM
admet-291	100	207	-4.62	-4.62	NUM
admet-291	100	208	10	10	NUM
admet-291	100	209	5	5	NUM
admet-291	100	210	177	177	NUM
admet-291	100	211	3	3	NUM
admet-291	100	212	1.59	1.59	NUM
admet-291	100	213	arglabin	arglabin	NOUN
admet-291	100	214	246	246	NUM
admet-291	100	215	1.48	1.48	NUM
admet-291	100	216	-2.78	-2.78	NOUN
admet-291	100	217	3	3	NUM
admet-291	100	218	0	0	NUM
admet-291	100	219	39	39	NUM
admet-291	100	220	0	0	NUM
admet-291	100	221	2.13	2.13	NUM
admet-291	100	222	camptothecin	camptothecin	NOUN
admet-291	100	223	348	348	NUM
admet-291	100	224	1.18	1.18	NUM
admet-291	100	225	-2.74	-2.74	NUM
admet-291	100	226	6	6	NUM
admet-291	100	227	1	1	NUM
admet-291	100	228	80	80	NUM
admet-291	100	229	1	1	NUM
admet-291	100	230	2.02	2.02	NUM
admet-291	100	231	carfilzomib	carfilzomib	NOUN
admet-291	100	232	720	720	NUM
admet-291	100	233	2.51	2.51	NUM
admet-291	100	234	-4.57	-4.57	NUM
admet-291	100	235	12	12	NUM
admet-291	100	236	4	4	NUM
admet-291	100	237	158	158	NUM
admet-291	100	238	20	20	NUM
admet-291	100	239	4.43	4.43	NUM
admet-291	100	240	combretastatin	combretastatin	NOUN
admet-291	100	241	334	334	NUM
admet-291	100	242	2.17	2.17	NUM
admet-291	100	243	-2.48	-2.48	NUM
admet-291	100	244	6	6	NUM
admet-291	100	245	2	2	NUM
admet-291	100	246	77	77	NUM
admet-291	100	247	7	7	NUM
admet-291	100	248	1.84	1.84	NUM
admet-291	100	249	docetaxel	docetaxel	NOUN
admet-291	100	250	808	808	NUM
admet-291	100	251	2.61	2.61	NUM
admet-291	100	252	-5.81	-5.81	NUM
admet-291	100	253	15	15	NUM
admet-291	100	254	5	5	NUM
admet-291	100	255	224	224	NUM
admet-291	100	256	13	13	NUM
admet-291	100	257	2.59	2.59	NUM
admet-291	100	258	ellipticine	ellipticine	NOUN
admet-291	100	259	246	246	NUM
admet-291	100	260	3.90	3.90	NUM
admet-291	100	261	-5.14	-5.14	NUM
admet-291	100	262	2	2	NUM
admet-291	100	263	1	1	NUM
admet-291	100	264	29	29	NUM
admet-291	100	265	0	0	NUM
admet-291	100	266	3.14	3.14	NUM
admet-291	100	267	etoposide	etoposide	NOUN
admet-291	100	268	589	589	NUM
admet-291	100	269	0.67	0.67	NUM
admet-291	100	270	-3.95	-3.95	NUM
admet-291	100	271	13	13	NUM
admet-291	100	272	3	3	NUM
admet-291	100	273	161	161	NUM
admet-291	100	274	5	5	NUM
admet-291	100	275	0.94	0.94	NUM
admet-291	100	276	exemestane	exemestane	NOUN
admet-291	100	277	296	296	NUM
admet-291	100	278	3.61	3.61	NUM
admet-291	100	279	-3.95	-3.95	NUM
admet-291	100	280	2	2	NUM
admet-291	100	281	0	0	NUM
admet-291	100	282	34	34	NUM
admet-291	100	283	0	0	NUM
admet-291	100	284	3.01	3.01	NUM
admet-291	100	285	formestane	formestane	NOUN
admet-291	100	286	302	302	NUM
admet-291	100	287	3.14	3.14	NUM
admet-291	100	288	-4.04	-4.04	NUM
admet-291	100	289	3	3	NUM
admet-291	100	290	1	1	NUM
admet-291	100	291	54	54	NUM
admet-291	100	292	0	0	NUM
admet-291	100	293	2.55	2.55	NUM
admet-291	100	294	homoharringtonine	homoharringtonine	NOUN
admet-291	100	295	546	546	NUM
admet-291	100	296	3.65	3.65	NUM
admet-291	100	297	-4.38	-4.38	NUM
admet-291	100	298	10	10	NUM
admet-291	100	299	2	2	NUM
admet-291	100	300	124	124	NUM
admet-291	100	301	11	11	NUM
admet-291	100	302	1.34	1.34	NUM
admet-291	100	303	irinotecan	irinotecan	NOUN
admet-291	100	304	587	587	NUM
admet-291	100	305	3.56	3.56	NUM
admet-291	100	306	-4.50	-4.50	NUM
admet-291	100	307	10	10	NUM
admet-291	100	308	1	1	NUM
admet-291	100	309	113	113	NUM
admet-291	100	310	5	5	NUM
admet-291	100	311	3.25	3.25	NUM
admet-291	100	312	paclitaxel	paclitaxel	NOUN
admet-291	100	313	854	854	NUM
admet-291	100	314	3.19	3.19	NUM
admet-291	100	315	-6.29	-6.29	NUM
admet-291	100	316	15	15	NUM
admet-291	100	317	4	4	NUM
admet-291	100	318	221	221	NUM
admet-291	100	319	14	14	NUM
admet-291	100	320	3.06	3.06	NUM
admet-291	100	321	podophyllotoxin	podophyllotoxin	NOUN
admet-291	100	322	414	414	NUM
admet-291	100	323	1.79	1.79	NUM
admet-291	100	324	-3.84	-3.84	NUM
admet-291	100	325	8	8	NUM
admet-291	100	326	1	1	NUM
admet-291	100	327	93	93	NUM
admet-291	100	328	4	4	NUM
admet-291	100	329	1.95	1.95	NUM
admet-291	100	330	rohitukine	rohitukine	NOUN
admet-291	100	331	305	305	NUM
admet-291	100	332	1.62	1.62	NUM
admet-291	100	333	-2.30	-2.30	PROPN
admet-291	100	334	6	6	NUM
admet-291	100	335	3	3	NUM
admet-291	100	336	90	90	NUM
admet-291	100	337	1	1	NUM
admet-291	100	338	-0.86	-0.86	NUM
admet-291	100	339	roscovitine	roscovitine	NOUN
admet-291	100	340	354	354	NUM
admet-291	100	341	2.58	2.58	NUM
admet-291	100	342	-3.93	-3.93	NUM
admet-291	100	343	7	7	NUM
admet-291	100	344	3	3	NUM
admet-291	100	345	88	88	NUM
admet-291	100	346	8	8	NUM
admet-291	100	347	4.45	4.45	NUM
admet-291	100	348	teniposide	teniposide	NOUN
admet-291	100	349	657	657	NUM
admet-291	100	350	1.35	1.35	NUM
admet-291	100	351	-4.85	-4.85	X
admet-291	100	352	13	13	NUM
admet-291	100	353	3	3	NUM
admet-291	100	354	189	189	NUM
admet-291	100	355	6	6	NUM
admet-291	100	356	2.52	2.52	NUM
admet-291	100	357	topotecan	topotecan	NOUN
admet-291	100	358	421	421	NUM
admet-291	100	359	0.46	0.46	NUM
admet-291	100	360	-1.96	-1.96	NUM
admet-291	100	361	8	8	NUM
admet-291	100	362	2	2	NUM
admet-291	100	363	103	103	NUM
admet-291	100	364	3	3	NUM
admet-291	100	365	0.93	0.93	NUM
admet-291	100	366	vinblastine	vinblastine	NOUN
admet-291	100	367	811	811	NUM
admet-291	100	368	3.30	3.30	NUM
admet-291	100	369	-5.08	-5.08	NUM
admet-291	100	370	13	13	NUM
admet-291	100	371	3	3	NUM
admet-291	100	372	154	154	NUM
admet-291	100	373	10	10	NUM
admet-291	100	374	4.88	4.88	NUM
admet-291	100	375	vincristine	vincristine	NOUN
admet-291	100	376	825	825	NUM
admet-291	100	377	2.98	2.98	NUM
admet-291	100	378	-5.53	-5.53	NOUN
admet-291	100	379	14	14	NUM
admet-291	100	380	3	3	NUM
admet-291	100	381	171	171	NUM
admet-291	100	382	10	10	NUM
admet-291	100	383	3.97	3.97	NUM
admet-291	100	384	vindesine	vindesine	NOUN
admet-291	100	385	754	754	NUM
admet-291	100	386	1.99	1.99	NUM
admet-291	100	387	-4.62	-4.62	NUM
admet-291	100	388	12	12	NUM
admet-291	100	389	5	5	NUM
admet-291	100	390	165	165	NUM
admet-291	100	391	7	7	NUM
admet-291	100	392	2.38	2.38	NUM
admet-291	100	393	vinflunine	vinflunine	NOUN
admet-291	100	394	817	817	NUM
admet-291	100	395	3.95	3.95	NUM
admet-291	100	396	-5.87	-5.87	NUM
admet-291	100	397	12	12	NUM
admet-291	100	398	2	2	NUM
admet-291	100	399	134	134	NUM
admet-291	100	400	10	10	NUM
admet-291	100	401	4.30	4.30	NUM
admet-291	100	402	vinorelbine	vinorelbine	NOUN
admet-291	100	403	779	779	NUM
admet-291	100	404	3.59	3.59	NUM
admet-291	100	405	-5.15	-5.15	NUM
admet-291	100	406	12	12	NUM
admet-291	100	407	2	2	NUM
admet-291	100	408	134	134	NUM
admet-291	100	409	10	10	NUM
admet-291	100	410	4.66	4.66	NUM
admet-291	100	411	helpful	helpful	ADJ
admet-291	100	412	in	in	ADP
admet-291	100	413	prospective	prospective	ADJ
admet-291	100	414	design	design	NOUN
admet-291	100	415	of	of	ADP
admet-291	100	416	anticancer	anticancer	NOUN
admet-291	100	417	molecules	molecule	NOUN
admet-291	100	418	from	from	ADP
admet-291	100	419	natural	natural	ADJ
admet-291	100	420	products	product	NOUN
admet-291	100	421	or	or	CCONJ
admet-291	100	422	identification	identification	NOUN
admet-291	100	423	of	of	ADP
admet-291	100	424	lead	lead	ADJ
admet-291	100	425	candidates	candidate	NOUN
admet-291	100	426	from	from	ADP
admet-291	100	427	natural	natural	ADJ
admet-291	100	428	products	product	NOUN
admet-291	100	429	that	that	PRON
admet-291	100	430	can	can	AUX
admet-291	100	431	successfully	successfully	ADV
admet-291	100	432	progress	progress	VERB
admet-291	100	433	to	to	ADP
admet-291	100	434	the	the	DET
admet-291	100	435	clinic	clinic	NOUN
admet-291	100	436	and	and	CCONJ
admet-291	100	437	becomes	become	VERB
admet-291	100	438	better	well	ADJ
admet-291	100	439	anticancer	anticancer	NOUN
admet-291	100	440	drug	drug	NOUN
admet-291	100	441	.	.	PUNCT
admet-291	101	1	for	for	ADP
admet-291	101	2	some	some	PRON
admet-291	101	3	of	of	ADP
admet-291	101	4	the	the	DET
admet-291	101	5	physicochemical	physicochemical	ADJ
admet-291	101	6	property	property	NOUN
admet-291	101	7	,	,	PUNCT
admet-291	101	8	specifically	specifically	ADV
admet-291	101	9	mw	mw	X
admet-291	101	10	,	,	PUNCT
admet-291	101	11	hba	hba	NOUN
admet-291	101	12	and	and	CCONJ
admet-291	101	13	nrot	nrot	PROPN
admet-291	101	14	lead	lead	VERB
admet-291	101	15	molecules	molecule	NOUN
admet-291	101	16	deepika	deepika	PROPN
admet-291	101	17	singh	singh	PROPN
admet-291	101	18	admet	admet	PROPN
admet-291	101	19	&	&	CCONJ
admet-291	101	20	dmpk	dmpk	PROPN
admet-291	101	21	4(2	4(2	NUM
admet-291	101	22	)	)	PUNCT
admet-291	101	23	(	(	PUNCT
admet-291	101	24	2016	2016	NUM
admet-291	101	25	)	)	PUNCT
admet-291	101	26	98	98	NUM
admet-291	101	27	-	-	SYM
admet-291	101	28	113	113	NUM
admet-291	101	29	106	106	NUM
admet-291	101	30	are	be	AUX
admet-291	101	31	showing	show	VERB
admet-291	101	32	better	well	ADV
admet-291	101	33	optimal	optimal	ADJ
admet-291	101	34	range	range	NOUN
admet-291	101	35	compare	compare	VERB
admet-291	101	36	to	to	ADP
admet-291	101	37	the	the	DET
admet-291	101	38	drug	drug	NOUN
admet-291	101	39	candidates	candidate	NOUN
admet-291	101	40	according	accord	VERB
admet-291	101	41	to	to	ADP
admet-291	101	42	the	the	DET
admet-291	101	43	ro5	ro5	NOUN
admet-291	101	44	,	,	PUNCT
admet-291	101	45	which	which	PRON
admet-291	101	46	are	be	AUX
admet-291	101	47	quite	quite	ADV
admet-291	101	48	significant	significant	ADJ
admet-291	101	49	for	for	ADP
admet-291	101	50	shaping	shape	VERB
admet-291	101	51	the	the	DET
admet-291	101	52	admet	admet	NOUN
admet-291	101	53	properties	property	NOUN
admet-291	101	54	of	of	ADP
admet-291	101	55	potential	potential	ADJ
admet-291	101	56	anticancer	anticancer	NOUN
admet-291	101	57	drug	drug	NOUN
admet-291	101	58	candidates	candidate	NOUN
admet-291	101	59	.	.	PUNCT
admet-291	102	1	profiling	profile	VERB
admet-291	102	2	adme	adme	NOUN
admet-291	102	3	space	space	NOUN
admet-291	102	4	of	of	ADP
admet-291	102	5	anticancer	anticancer	NOUN
admet-291	102	6	molecules	molecule	NOUN
admet-291	102	7	potential	potential	ADJ
admet-291	102	8	therapeutic	therapeutic	ADJ
admet-291	102	9	compounds	compound	NOUN
admet-291	102	10	are	be	AUX
admet-291	102	11	useless	useless	ADJ
admet-291	102	12	without	without	ADP
admet-291	102	13	having	have	VERB
admet-291	102	14	a	a	DET
admet-291	102	15	good	good	ADJ
admet-291	102	16	admet	admet	NOUN
admet-291	102	17	profile	profile	NOUN
admet-291	102	18	,	,	PUNCT
admet-291	102	19	and	and	CCONJ
admet-291	102	20	thus	thus	ADV
admet-291	102	21	,	,	PUNCT
admet-291	102	22	it	it	PRON
admet-291	102	23	is	be	AUX
admet-291	102	24	essential	essential	ADJ
admet-291	102	25	to	to	PART
admet-291	102	26	find	find	VERB
admet-291	102	27	the	the	DET
admet-291	102	28	source	source	NOUN
admet-291	102	29	of	of	ADP
admet-291	102	30	such	such	ADJ
admet-291	102	31	diminished	diminished	ADJ
admet-291	102	32	potency	potency	NOUN
admet-291	102	33	for	for	ADP
admet-291	102	34	developing	develop	VERB
admet-291	102	35	a	a	DET
admet-291	102	36	drug	drug	NOUN
admet-291	102	37	.	.	PUNCT
admet-291	103	1	significant	significant	ADJ
admet-291	103	2	advances	advance	NOUN
admet-291	103	3	in	in	ADP
admet-291	103	4	the	the	DET
admet-291	103	5	development	development	NOUN
admet-291	103	6	of	of	ADP
admet-291	103	7	ht	ht	PROPN
admet-291	103	8	in	in	ADP
admet-291	103	9	vitro	vitro	X
admet-291	103	10	adme	adme	NOUN
admet-291	103	11	assays	assay	NOUN
admet-291	103	12	have	have	AUX
admet-291	103	13	enabled	enable	VERB
admet-291	103	14	computational	computational	ADJ
admet-291	103	15	scientist	scientist	NOUN
admet-291	103	16	to	to	PART
admet-291	103	17	make	make	VERB
admet-291	103	18	robust	robust	ADJ
admet-291	103	19	computational	computational	ADJ
admet-291	103	20	models	model	NOUN
admet-291	103	21	to	to	ADP
admet-291	103	22	the	the	DET
admet-291	103	23	earlier	early	ADJ
admet-291	103	24	assessment	assessment	NOUN
admet-291	103	25	of	of	ADP
admet-291	103	26	potential	potential	ADJ
admet-291	103	27	liabilities	liability	NOUN
admet-291	103	28	(	(	PUNCT
admet-291	103	29	low	low	ADJ
admet-291	103	30	permeability	permeability	NOUN
admet-291	103	31	,	,	PUNCT
admet-291	103	32	susceptibility	susceptibility	NOUN
admet-291	103	33	to	to	PART
admet-291	103	34	efflux	efflux	VERB
admet-291	103	35	transporters	transporter	NOUN
admet-291	103	36	,	,	PUNCT
admet-291	103	37	etc	etc	X
admet-291	103	38	.	.	X
admet-291	103	39	)	)	PUNCT
admet-291	104	1	associated	associate	VERB
admet-291	104	2	with	with	ADP
admet-291	104	3	new	new	ADJ
admet-291	104	4	potential	potential	ADJ
admet-291	104	5	lead	lead	NOUN
admet-291	104	6	compounds	compound	NOUN
admet-291	104	7	.	.	PUNCT
admet-291	105	1	in	in	ADP
admet-291	105	2	order	order	NOUN
admet-291	105	3	to	to	PART
admet-291	105	4	gain	gain	VERB
admet-291	105	5	a	a	DET
admet-291	105	6	better	well	ADJ
admet-291	105	7	perspective	perspective	NOUN
admet-291	105	8	on	on	ADP
admet-291	105	9	the	the	DET
admet-291	105	10	adme	adme	NOUN
admet-291	105	11	properties	property	NOUN
admet-291	105	12	of	of	ADP
admet-291	105	13	drugs	drug	NOUN
admet-291	105	14	and	and	CCONJ
admet-291	105	15	lead	lead	ADJ
admet-291	105	16	candidates	candidate	NOUN
admet-291	105	17	,	,	PUNCT
admet-291	105	18	we	we	PRON
admet-291	105	19	evaluated	evaluate	VERB
admet-291	105	20	the	the	DET
admet-291	105	21	in	in	ADP
admet-291	105	22	silico	silico	NOUN
admet-291	105	23	profiling	profiling	NOUN
admet-291	105	24	of	of	ADP
admet-291	105	25	these	these	DET
admet-291	105	26	compounds	compound	NOUN
admet-291	105	27	to	to	PART
admet-291	105	28	assess	assess	VERB
admet-291	105	29	caco2	caco2	NOUN
admet-291	105	30	cell	cell	NOUN
admet-291	105	31	permeability	permeability	NOUN
admet-291	105	32	,	,	PUNCT
admet-291	105	33	human	human	ADJ
admet-291	105	34	intestinal	intestinal	ADJ
admet-291	105	35	absorption	absorption	NOUN
admet-291	105	36	,	,	PUNCT
admet-291	105	37	and	and	CCONJ
admet-291	105	38	p	p	X
admet-291	105	39	-	-	PUNCT
admet-291	105	40	gp	gp	NOUN
admet-291	105	41	efflux	efflux	NOUN
admet-291	105	42	liability	liability	NOUN
admet-291	105	43	[	[	X
admet-291	105	44	23	23	NUM
admet-291	105	45	]	]	PUNCT
admet-291	105	46	.	.	PUNCT
admet-291	106	1	we	we	PRON
admet-291	106	2	can	can	AUX
admet-291	106	3	classify	classify	VERB
admet-291	106	4	the	the	DET
admet-291	106	5	permeability	permeability	NOUN
admet-291	106	6	of	of	ADP
admet-291	106	7	a	a	DET
admet-291	106	8	molecule	molecule	NOUN
admet-291	106	9	as	as	ADP
admet-291	106	10	low	low	ADJ
admet-291	106	11	,	,	PUNCT
admet-291	106	12	or	or	CCONJ
admet-291	106	13	high	high	ADJ
admet-291	106	14	based	base	VERB
admet-291	106	15	on	on	ADP
admet-291	106	16	the	the	DET
admet-291	106	17	predictive	predictive	ADJ
admet-291	106	18	model	model	NOUN
admet-291	106	19	and	and	CCONJ
admet-291	106	20	its	its	PRON
admet-291	106	21	relative	relative	ADJ
admet-291	106	22	range	range	NOUN
admet-291	106	23	of	of	ADP
admet-291	106	24	log	log	NOUN
admet-291	106	25	papp	papp	NOUN
admet-291	106	26	(	(	PUNCT
admet-291	106	27	in	in	ADP
admet-291	106	28	10	10	NUM
admet-291	106	29	-	-	SYM
admet-291	106	30	6	6	NUM
admet-291	106	31	cm	cm	NOUN
admet-291	106	32	/	/	SYM
admet-291	106	33	s	s	PART
admet-291	106	34	)	)	PUNCT
admet-291	106	35	rates	rate	NOUN
admet-291	106	36	are	be	AUX
admet-291	106	37	,	,	PUNCT
admet-291	106	38	as	as	SCONJ
admet-291	106	39	follows	follow	VERB
admet-291	106	40	:	:	PUNCT
admet-291	106	41	log	log	PROPN
admet-291	106	42	papp	papp	PROPN
admet-291	106	43	>	>	X
admet-291	106	44	0.9	0.9	NUM
admet-291	106	45	,	,	PUNCT
admet-291	106	46	considered	consider	VERB
admet-291	106	47	to	to	PART
admet-291	106	48	be	be	AUX
admet-291	106	49	high	high	ADJ
admet-291	106	50	permeability	permeability	NOUN
admet-291	106	51	,	,	PUNCT
admet-291	106	52	while	while	SCONJ
admet-291	106	53	log	log	VERB
admet-291	106	54	papp	papp	NOUN
admet-291	106	55	<	<	X
admet-291	106	56	0.9	0.9	NUM
admet-291	106	57	,	,	PUNCT
admet-291	106	58	considered	consider	VERB
admet-291	106	59	to	to	PART
admet-291	106	60	be	be	AUX
admet-291	106	61	low	low	ADJ
admet-291	106	62	permeability	permeability	NOUN
admet-291	106	63	of	of	ADP
admet-291	106	64	the	the	DET
admet-291	106	65	molecule	molecule	NOUN
admet-291	106	66	.	.	PUNCT
admet-291	107	1	the	the	DET
admet-291	107	2	caco2	caco2	NOUN
admet-291	107	3	cell	cell	NOUN
admet-291	107	4	permeability	permeability	NOUN
admet-291	107	5	values	value	NOUN
admet-291	107	6	for	for	ADP
admet-291	107	7	lead	lead	ADJ
admet-291	107	8	candidates	candidate	NOUN
admet-291	107	9	and	and	CCONJ
admet-291	107	10	drugs	drug	NOUN
admet-291	107	11	are	be	AUX
admet-291	107	12	mentioned	mention	VERB
admet-291	107	13	in	in	ADP
admet-291	107	14	table	table	NOUN
admet-291	107	15	2	2	NUM
admet-291	107	16	.	.	PUNCT
admet-291	108	1	in	in	ADP
admet-291	108	2	the	the	DET
admet-291	108	3	caco2	caco2	NOUN
admet-291	108	4	cell	cell	NOUN
admet-291	108	5	permeability	permeability	NOUN
admet-291	108	6	prediction	prediction	NOUN
admet-291	108	7	,	,	PUNCT
admet-291	108	8	70	70	NUM
admet-291	108	9	%	%	NOUN
admet-291	108	10	of	of	ADP
admet-291	108	11	the	the	DET
admet-291	108	12	lead	lead	ADJ
admet-291	108	13	candidates	candidate	NOUN
admet-291	108	14	show	show	VERB
admet-291	108	15	high	high	ADJ
admet-291	108	16	log	log	NOUN
admet-291	108	17	papp	papp	NOUN
admet-291	108	18	values	value	NOUN
admet-291	108	19	;	;	PUNCT
admet-291	108	20	surprisingly	surprisingly	ADV
admet-291	108	21	the	the	DET
admet-291	108	22	drugs	drug	NOUN
admet-291	108	23	had	have	VERB
admet-291	108	24	a	a	DET
admet-291	108	25	lower	low	ADJ
admet-291	108	26	percentage	percentage	NOUN
admet-291	108	27	(	(	PUNCT
admet-291	108	28	30	30	NUM
admet-291	108	29	%	%	NOUN
admet-291	108	30	)	)	PUNCT
admet-291	108	31	with	with	ADP
admet-291	108	32	high	high	ADJ
admet-291	108	33	log	log	NOUN
admet-291	108	34	papp	papp	NOUN
admet-291	108	35	values	value	NOUN
admet-291	108	36	.	.	PUNCT
admet-291	109	1	a	a	DET
admet-291	109	2	similar	similar	ADJ
admet-291	109	3	discrepancy	discrepancy	NOUN
admet-291	109	4	was	be	AUX
admet-291	109	5	observed	observe	VERB
admet-291	109	6	when	when	SCONJ
admet-291	109	7	we	we	PRON
admet-291	109	8	assessed	assess	VERB
admet-291	109	9	p	p	NOUN
admet-291	109	10	-	-	PUNCT
admet-291	109	11	gp	gp	NOUN
admet-291	109	12	efflux	efflux	NOUN
admet-291	109	13	liabilities	liability	NOUN
admet-291	109	14	for	for	ADP
admet-291	109	15	drugs	drug	NOUN
admet-291	109	16	and	and	CCONJ
admet-291	109	17	lead	lead	ADJ
admet-291	109	18	candidates	candidate	NOUN
admet-291	109	19	.	.	PUNCT
admet-291	110	1	the	the	DET
admet-291	110	2	p	p	NOUN
admet-291	110	3	-	-	PUNCT
admet-291	110	4	gp	gp	NOUN
admet-291	110	5	efflux	efflux	NOUN
admet-291	110	6	liability	liability	NOUN
admet-291	110	7	was	be	AUX
admet-291	110	8	assessed	assess	VERB
admet-291	110	9	utilizing	utilize	VERB
admet-291	110	10	preadmet	preadmet	NOUN
admet-291	110	11	’s	’s	PART
admet-291	111	1	[	[	X
admet-291	111	2	https://preadmet.bmdrc.kr/	https://preadmet.bmdrc.kr/	X
admet-291	111	3	]	]	X
admet-291	111	4	p	p	X
admet-291	111	5	-	-	PUNCT
admet-291	111	6	gp_substrate	gp_substrate	ADJ
admet-291	111	7	model	model	NOUN
admet-291	111	8	.	.	PUNCT
admet-291	112	1	prediction	prediction	NOUN
admet-291	112	2	of	of	ADP
admet-291	112	3	the	the	DET
admet-291	112	4	likelihood	likelihood	NOUN
admet-291	112	5	of	of	ADP
admet-291	112	6	pgp	pgp	NOUN
admet-291	112	7	efflux	efflux	NOUN
admet-291	112	8	shows	show	VERB
admet-291	112	9	that	that	SCONJ
admet-291	112	10	all	all	DET
admet-291	112	11	drugs	drug	NOUN
admet-291	112	12	and	and	CCONJ
admet-291	112	13	60	60	NUM
admet-291	112	14	%	%	NOUN
admet-291	112	15	of	of	ADP
admet-291	112	16	the	the	DET
admet-291	112	17	lead	lead	ADJ
admet-291	112	18	candidates	candidate	NOUN
admet-291	112	19	are	be	AUX
admet-291	112	20	considered	consider	VERB
admet-291	112	21	to	to	PART
admet-291	112	22	be	be	AUX
admet-291	112	23	p	p	NOUN
admet-291	112	24	-	-	PUNCT
admet-291	112	25	gp	gp	NOUN
admet-291	112	26	efflux	efflux	NOUN
admet-291	112	27	substrates	substrate	NOUN
admet-291	112	28	;	;	PUNCT
admet-291	112	29	the	the	DET
admet-291	112	30	predicted	predict	VERB
admet-291	112	31	values	value	NOUN
admet-291	112	32	from	from	ADP
admet-291	112	33	the	the	DET
admet-291	112	34	pgp_substrate	pgp_substrate	NOUN
admet-291	112	35	model	model	NOUN
admet-291	112	36	for	for	ADP
admet-291	112	37	both	both	DET
admet-291	112	38	drugs	drug	NOUN
admet-291	112	39	and	and	CCONJ
admet-291	112	40	lead	lead	ADJ
admet-291	112	41	candidates	candidate	NOUN
admet-291	112	42	dataset	dataset	VERB
admet-291	112	43	are	be	AUX
admet-291	112	44	mentioned	mention	VERB
admet-291	112	45	in	in	ADP
admet-291	112	46	table	table	NOUN
admet-291	112	47	2	2	NUM
admet-291	112	48	.	.	PUNCT
admet-291	113	1	an	an	DET
admet-291	113	2	optimal	optimal	ADJ
admet-291	113	3	clinical	clinical	ADJ
admet-291	113	4	candidate	candidate	NOUN
admet-291	113	5	could	could	AUX
admet-291	113	6	be	be	AUX
admet-291	113	7	achieved	achieve	VERB
admet-291	113	8	if	if	SCONJ
admet-291	113	9	it	it	PRON
admet-291	113	10	is	be	AUX
admet-291	113	11	possessed	possess	VERB
admet-291	113	12	both	both	CCONJ
admet-291	113	13	high	high	ADJ
admet-291	113	14	log	log	NOUN
admet-291	113	15	papp	papp	NOUN
admet-291	113	16	and	and	CCONJ
admet-291	113	17	low	low	ADJ
admet-291	113	18	p	p	NOUN
admet-291	113	19	-	-	PUNCT
admet-291	113	20	gp	gp	NOUN
admet-291	113	21	efflux	efflux	NOUN
admet-291	113	22	liability	liability	NOUN
admet-291	113	23	.	.	PUNCT
admet-291	114	1	the	the	DET
admet-291	114	2	intestine	intestine	NOUN
admet-291	114	3	is	be	AUX
admet-291	114	4	the	the	DET
admet-291	114	5	primary	primary	ADJ
admet-291	114	6	site	site	NOUN
admet-291	114	7	of	of	ADP
admet-291	114	8	absorption	absorption	NOUN
admet-291	114	9	for	for	ADP
admet-291	114	10	the	the	DET
admet-291	114	11	orally	orally	ADV
admet-291	114	12	administered	administer	VERB
admet-291	114	13	drugs	drug	NOUN
admet-291	114	14	;	;	PUNCT
admet-291	114	15	hence	hence	ADV
admet-291	114	16	,	,	PUNCT
admet-291	114	17	we	we	PRON
admet-291	114	18	predicted	predict	VERB
admet-291	114	19	the	the	DET
admet-291	114	20	percentage	percentage	NOUN
admet-291	114	21	(	(	PUNCT
admet-291	114	22	%	%	NOUN
admet-291	114	23	)	)	PUNCT
admet-291	114	24	of	of	ADP
admet-291	114	25	human	human	ADJ
admet-291	114	26	intestinal	intestinal	ADJ
admet-291	114	27	absorption	absorption	NOUN
admet-291	114	28	of	of	ADP
admet-291	114	29	the	the	DET
admet-291	114	30	drugs	drug	NOUN
admet-291	114	31	and	and	CCONJ
admet-291	114	32	lead	lead	ADJ
admet-291	114	33	candidates	candidate	NOUN
admet-291	114	34	.	.	PUNCT
admet-291	115	1	systemic	systemic	ADJ
admet-291	115	2	oral	oral	ADJ
admet-291	115	3	dosage	dosage	NOUN
admet-291	115	4	requires	require	VERB
admet-291	115	5	compound	compound	NOUN
admet-291	115	6	properties	property	NOUN
admet-291	115	7	that	that	PRON
admet-291	115	8	allow	allow	VERB
admet-291	115	9	for	for	ADP
admet-291	115	10	dissolution	dissolution	NOUN
admet-291	115	11	and	and	CCONJ
admet-291	115	12	stability	stability	NOUN
admet-291	115	13	in	in	ADP
admet-291	115	14	the	the	DET
admet-291	115	15	gastrointestinal	gastrointestinal	ADJ
admet-291	115	16	(	(	PUNCT
admet-291	115	17	gi	gi	INTJ
admet-291	115	18	)	)	PUNCT
admet-291	115	19	tract	tract	NOUN
admet-291	115	20	,	,	PUNCT
admet-291	115	21	including	include	VERB
admet-291	115	22	the	the	DET
admet-291	115	23	acidic	acidic	ADJ
admet-291	115	24	environment	environment	NOUN
admet-291	115	25	of	of	ADP
admet-291	115	26	the	the	DET
admet-291	115	27	stomach	stomach	NOUN
admet-291	115	28	(	(	PUNCT
admet-291	115	29	ph	ph	NOUN
admet-291	115	30	1–2	1–2	NUM
admet-291	115	31	in	in	ADP
admet-291	115	32	fasted	fasted	ADJ
admet-291	115	33	state	state	NOUN
admet-291	115	34	,	,	PUNCT
admet-291	115	35	3–7	3–7	NUM
admet-291	115	36	in	in	ADP
admet-291	115	37	fed	fed	PROPN
admet-291	115	38	state	state	PROPN
admet-291	115	39	)	)	PUNCT
admet-291	115	40	and	and	CCONJ
admet-291	115	41	the	the	DET
admet-291	115	42	close	close	ADJ
admet-291	115	43	to	to	ADP
admet-291	115	44	neutral	neutral	ADJ
admet-291	115	45	environment	environment	NOUN
admet-291	115	46	(	(	PUNCT
admet-291	115	47	ph	ph	ADJ
admet-291	115	48	4.4–6.6	4.4–6.6	NOUN
admet-291	115	49	)	)	PUNCT
admet-291	115	50	of	of	ADP
admet-291	115	51	the	the	DET
admet-291	115	52	small	small	ADJ
admet-291	115	53	intestine	intestine	NOUN
admet-291	115	54	[	[	X
admet-291	115	55	28	28	NUM
admet-291	115	56	.	.	PUNCT
admet-291	116	1	the	the	DET
admet-291	116	2	%	%	NOUN
admet-291	116	3	human	human	ADJ
admet-291	116	4	intestinal	intestinal	ADJ
admet-291	116	5	absorption	absorption	NOUN
admet-291	116	6	of	of	ADP
admet-291	116	7	the	the	DET
admet-291	116	8	drugs	drug	NOUN
admet-291	116	9	and	and	CCONJ
admet-291	116	10	lead	lead	ADJ
admet-291	116	11	candidates	candidate	NOUN
admet-291	116	12	was	be	AUX
admet-291	116	13	assessed	assess	VERB
admet-291	116	14	by	by	ADP
admet-291	116	15	using	use	VERB
admet-291	116	16	pkcsm	pkcsm	NOUN
admet-291	116	17	web	web	NOUN
admet-291	116	18	server	server	NOUN
admet-291	116	19	model	model	NOUN
admet-291	116	20	[	[	X
admet-291	116	21	21	21	NUM
admet-291	116	22	]	]	PUNCT
admet-291	116	23	.	.	PUNCT
admet-291	117	1	all	all	DET
admet-291	117	2	the	the	DET
admet-291	117	3	drugs	drug	NOUN
admet-291	117	4	are	be	AUX
admet-291	117	5	showing	show	VERB
admet-291	117	6	good	good	ADJ
admet-291	117	7	predicted	predict	VERB
admet-291	117	8	human	human	ADJ
admet-291	117	9	intestinal	intestinal	ADJ
admet-291	117	10	absorption	absorption	NOUN
admet-291	117	11	>	>	X
admet-291	117	12	60	60	NUM
admet-291	117	13	%	%	NOUN
admet-291	117	14	;	;	PUNCT
admet-291	117	15	while	while	SCONJ
admet-291	117	16	93	93	NUM
admet-291	117	17	%	%	NOUN
admet-291	117	18	of	of	ADP
admet-291	117	19	the	the	DET
admet-291	117	20	lead	lead	ADJ
admet-291	117	21	candidates	candidate	NOUN
admet-291	117	22	predicted	predict	VERB
admet-291	117	23	>	>	SYM
admet-291	117	24	70	70	NUM
admet-291	117	25	%	%	NOUN
admet-291	117	26	human	human	ADJ
admet-291	117	27	intestinal	intestinal	ADJ
admet-291	117	28	absorption	absorption	NOUN
admet-291	117	29	.	.	PUNCT
admet-291	118	1	the	the	DET
admet-291	118	2	predicted	predict	VERB
admet-291	118	3	%	%	NOUN
admet-291	118	4	human	human	ADJ
admet-291	118	5	intestinal	intestinal	ADJ
admet-291	118	6	absorption	absorption	NOUN
admet-291	118	7	values	value	NOUN
admet-291	118	8	for	for	ADP
admet-291	118	9	both	both	DET
admet-291	118	10	drugs	drug	NOUN
admet-291	118	11	and	and	CCONJ
admet-291	118	12	lead	lead	ADJ
admet-291	118	13	candidates	candidate	NOUN
admet-291	118	14	dataset	dataset	VERB
admet-291	118	15	are	be	AUX
admet-291	118	16	mentioned	mention	VERB
admet-291	118	17	in	in	ADP
admet-291	118	18	table	table	NOUN
admet-291	118	19	2	2	NUM
admet-291	118	20	.	.	PUNCT
admet-291	119	1	many	many	ADJ
admet-291	119	2	of	of	ADP
admet-291	119	3	the	the	DET
admet-291	119	4	drugs	drug	NOUN
admet-291	119	5	in	in	ADP
admet-291	119	6	plasma	plasma	NOUN
admet-291	119	7	will	will	AUX
admet-291	119	8	exist	exist	VERB
admet-291	119	9	in	in	ADP
admet-291	119	10	equilibrium	equilibrium	NOUN
admet-291	119	11	between	between	ADP
admet-291	119	12	an	an	DET
admet-291	119	13	unbound	unbound	NOUN
admet-291	119	14	state	state	NOUN
admet-291	119	15	and	and	CCONJ
admet-291	119	16	a	a	DET
admet-291	119	17	bound	bind	VERB
admet-291	119	18	to	to	PART
admet-291	119	19	serum	serum	VERB
admet-291	119	20	proteins	protein	NOUN
admet-291	119	21	or	or	CCONJ
admet-291	119	22	whole	whole	ADJ
admet-291	119	23	blood	blood	NOUN
admet-291	119	24	proteins	protein	NOUN
admet-291	119	25	at	at	ADP
admet-291	119	26	various	various	ADJ
admet-291	119	27	affinities	affinity	NOUN
admet-291	119	28	.	.	PUNCT
admet-291	120	1	it	it	PRON
admet-291	120	2	is	be	AUX
admet-291	120	3	commonly	commonly	ADV
admet-291	120	4	accepted	accept	VERB
admet-291	120	5	that	that	SCONJ
admet-291	120	6	only	only	ADJ
admet-291	120	7	unbound	unbound	NOUN
admet-291	120	8	drug	drug	NOUN
admet-291	120	9	may	may	AUX
admet-291	120	10	interact	interact	VERB
admet-291	120	11	with	with	ADP
admet-291	120	12	anticipated	anticipate	VERB
admet-291	120	13	molecular	molecular	ADJ
admet-291	120	14	targets	target	NOUN
admet-291	120	15	[	[	X
admet-291	120	16	24	24	NUM
admet-291	120	17	]	]	PUNCT
admet-291	120	18	;	;	PUNCT
admet-291	120	19	hence	hence	ADV
admet-291	120	20	,	,	PUNCT
admet-291	120	21	the	the	DET
admet-291	120	22	efficacy	efficacy	NOUN
admet-291	120	23	of	of	ADP
admet-291	120	24	a	a	DET
admet-291	120	25	drug	drug	NOUN
admet-291	120	26	might	might	AUX
admet-291	120	27	affect	affect	VERB
admet-291	120	28	by	by	ADP
admet-291	120	29	the	the	DET
admet-291	120	30	degree	degree	NOUN
admet-291	120	31	to	to	PART
admet-291	120	32	which	which	PRON
admet-291	120	33	it	it	PRON
admet-291	120	34	binds	bind	VERB
admet-291	120	35	whole	whole	ADJ
admet-291	120	36	blood	blood	NOUN
admet-291	120	37	proteins	protein	NOUN
admet-291	120	38	.	.	PUNCT
admet-291	121	1	we	we	PRON
admet-291	121	2	have	have	AUX
admet-291	121	3	predicted	predict	VERB
admet-291	121	4	the	the	DET
admet-291	121	5	fraction	fraction	NOUN
admet-291	121	6	unbound	unbound	NOUN
admet-291	121	7	of	of	ADP
admet-291	121	8	both	both	DET
admet-291	121	9	drugs	drug	NOUN
admet-291	121	10	and	and	CCONJ
admet-291	121	11	lead	lead	VERB
admet-291	121	12	candidates	candidate	NOUN
admet-291	121	13	through	through	ADP
admet-291	121	14	the	the	DET
admet-291	121	15	predictive	predictive	ADJ
admet-291	121	16	model	model	NOUN
admet-291	121	17	of	of	ADP
admet-291	121	18	pkcsm	pkcsm	NOUN
admet-291	121	19	,	,	PUNCT
admet-291	121	20	which	which	PRON
admet-291	121	21	was	be	AUX
admet-291	121	22	built	build	VERB
admet-291	121	23	using	use	VERB
admet-291	121	24	the	the	DET
admet-291	121	25	measured	measure	VERB
admet-291	121	26	free	free	ADJ
admet-291	121	27	proportion	proportion	NOUN
admet-291	121	28	of	of	ADP
admet-291	121	29	552	552	NUM
admet-291	121	30	compounds	compound	NOUN
admet-291	121	31	in	in	ADP
admet-291	121	32	human	human	ADJ
admet-291	121	33	blood	blood	NOUN
admet-291	121	34	(	(	PUNCT
admet-291	121	35	fu	fu	NOUN
admet-291	121	36	)	)	PUNCT
admet-291	121	37	.	.	PUNCT
admet-291	122	1	we	we	PRON
admet-291	122	2	also	also	ADV
admet-291	122	3	evaluated	evaluate	VERB
admet-291	122	4	the	the	DET
admet-291	122	5	steady	steady	ADJ
admet-291	122	6	-	-	PUNCT
admet-291	122	7	state	state	NOUN
admet-291	122	8	volume	volume	NOUN
admet-291	122	9	of	of	ADP
admet-291	122	10	distribution	distribution	NOUN
admet-291	122	11	(	(	PUNCT
admet-291	122	12	vdss	vdss	ADV
admet-291	122	13	)	)	PUNCT
admet-291	122	14	of	of	ADP
admet-291	122	15	drugs	drug	NOUN
admet-291	122	16	and	and	CCONJ
admet-291	122	17	lead	lead	ADJ
admet-291	122	18	candidates	candidate	NOUN
admet-291	122	19	;	;	PUNCT
admet-291	122	20	another	another	DET
admet-291	122	21	important	important	ADJ
admet-291	122	22	parameter	parameter	NOUN
admet-291	122	23	,	,	PUNCT
admet-291	122	24	which	which	PRON
admet-291	122	25	suggests	suggest	VERB
admet-291	122	26	the	the	DET
admet-291	122	27	total	total	ADJ
admet-291	122	28	dose	dose	NOUN
admet-291	122	29	of	of	ADP
admet-291	122	30	a	a	DET
admet-291	122	31	drug	drug	NOUN
admet-291	122	32	would	would	AUX
admet-291	122	33	be	be	AUX
admet-291	122	34	required	require	VERB
admet-291	122	35	to	to	PART
admet-291	122	36	be	be	AUX
admet-291	122	37	uniformly	uniformly	ADV
admet-291	122	38	distributed	distribute	VERB
admet-291	122	39	to	to	PART
admet-291	122	40	provide	provide	VERB
admet-291	122	41	the	the	DET
admet-291	122	42	similar	similar	ADJ
admet-291	122	43	concentration	concentration	NOUN
admet-291	122	44	as	as	ADP
admet-291	122	45	in	in	ADP
admet-291	122	46	blood	blood	NOUN
admet-291	122	47	plasma	plasma	NOUN
admet-291	122	48	.	.	PUNCT
admet-291	123	1	the	the	DET
admet-291	123	2	values	value	NOUN
admet-291	123	3	of	of	ADP
admet-291	123	4	predicted	predict	VERB
admet-291	123	5	fraction	fraction	NOUN
admet-291	123	6	unbound	unbound	NOUN
admet-291	123	7	(	(	PUNCT
admet-291	123	8	fu	fu	NOUN
admet-291	123	9	)	)	PUNCT
admet-291	123	10	and	and	CCONJ
admet-291	123	11	vdss	vdss	ADJ
admet-291	123	12	values	value	NOUN
admet-291	123	13	for	for	ADP
admet-291	123	14	both	both	DET
admet-291	123	15	drugs	drug	NOUN
admet-291	123	16	and	and	CCONJ
admet-291	123	17	lead	lead	ADJ
admet-291	123	18	candidates	candidate	NOUN
admet-291	123	19	dataset	dataset	VERB
admet-291	123	20	are	be	AUX
admet-291	123	21	mentioned	mention	VERB
admet-291	123	22	in	in	ADP
admet-291	123	23	table	table	NOUN
admet-291	123	24	2	2	NUM
admet-291	123	25	.	.	PUNCT
admet-291	123	26	evaluation	evaluation	NOUN
admet-291	123	27	of	of	ADP
admet-291	123	28	individual	individual	ADJ
admet-291	123	29	adme	adme	NOUN
admet-291	123	30	properties	property	NOUN
admet-291	123	31	(	(	PUNCT
admet-291	123	32	papp	papp	NOUN
admet-291	123	33	,	,	PUNCT
admet-291	123	34	p	p	NOUN
admet-291	123	35	-	-	PUNCT
admet-291	123	36	gp	gp	NOUN
admet-291	123	37	,	,	PUNCT
admet-291	123	38	fu	fu	PROPN
admet-291	123	39	)	)	PUNCT
admet-291	123	40	suggested	suggest	VERB
admet-291	123	41	that	that	SCONJ
admet-291	123	42	to	to	PART
admet-291	123	43	increase	increase	VERB
admet-291	123	44	the	the	DET
admet-291	123	45	probability	probability	NOUN
admet-291	123	46	of	of	ADP
admet-291	123	47	success	success	NOUN
admet-291	123	48	,	,	PUNCT
admet-291	123	49	the	the	DET
admet-291	123	50	design	design	NOUN
admet-291	123	51	should	should	AUX
admet-291	123	52	focus	focus	VERB
admet-291	123	53	on	on	ADP
admet-291	123	54	optimizing	optimize	VERB
admet-291	123	55	all	all	DET
admet-291	123	56	properties	property	NOUN
admet-291	123	57	of	of	ADP
admet-291	123	58	a	a	DET
admet-291	123	59	molecule	molecule	NOUN
admet-291	123	60	.	.	PUNCT
admet-291	124	1	admet	admet	PROPN
admet-291	124	2	&	&	CCONJ
admet-291	124	3	dmpk	dmpk	PROPN
admet-291	124	4	4(2	4(2	NUM
admet-291	124	5	)	)	PUNCT
admet-291	124	6	(	(	PUNCT
admet-291	124	7	2016	2016	NUM
admet-291	124	8	)	)	PUNCT
admet-291	124	9	98	98	NUM
admet-291	124	10	-	-	SYM
admet-291	124	11	113	113	NUM
admet-291	124	12	defining	define	VERB
admet-291	124	13	natural	natural	ADJ
admet-291	124	14	product	product	NOUN
admet-291	124	15	derived	derive	VERB
admet-291	124	16	anticancer	anticancer	NOUN
admet-291	124	17	drug	drug	NOUN
admet-291	124	18	space	space	NOUN
admet-291	124	19	doi	doi	NOUN
admet-291	124	20	:	:	PUNCT
admet-291	124	21	10.5599	10.5599	NUM
admet-291	124	22	/	/	SYM
admet-291	124	23	admet.4.2.291	admet.4.2.291	PROPN
admet-291	124	24	107	107	NUM
admet-291	124	25	table	table	NOUN
admet-291	124	26	2	2	NUM
admet-291	124	27	.	.	PUNCT
admet-291	124	28	computed	compute	VERB
admet-291	124	29	adme	adme	NOUN
admet-291	124	30	properties	property	NOUN
admet-291	124	31	for	for	ADP
admet-291	124	32	anticancer	anticancer	NOUN
admet-291	124	33	lead	lead	NOUN
admet-291	124	34	candidates	candidate	NOUN
admet-291	124	35	and	and	CCONJ
admet-291	124	36	drugs	drug	NOUN
admet-291	124	37	.	.	PUNCT
admet-291	125	1	lead	lead	ADJ
admet-291	125	2	candidates	candidate	NOUN
admet-291	125	3	caco2	caco2	NOUN
admet-291	125	4	permeability	permeability	NOUN
admet-291	125	5	(	(	PUNCT
admet-291	125	6	log	log	PROPN
admet-291	125	7	papp	papp	NOUN
admet-291	125	8	in	in	ADP
admet-291	125	9	10	10	NUM
admet-291	125	10	-6	-6	NOUN
admet-291	125	11	cm	cm	NOUN
admet-291	125	12	/	/	SYM
admet-291	125	13	s	s	PART
admet-291	125	14	)	)	PUNCT
admet-291	125	15	intestinal	intestinal	ADJ
admet-291	125	16	absorption	absorption	NOUN
admet-291	125	17	(	(	PUNCT
admet-291	125	18	human	human	NOUN
admet-291	125	19	)	)	PUNCT
admet-291	125	20	(	(	PUNCT
admet-291	125	21	%	%	NOUN
admet-291	125	22	absorbed	absorb	VERB
admet-291	125	23	)	)	PUNCT
admet-291	125	24	vdss	vdss	ADV
admet-291	125	25	(	(	PUNCT
admet-291	125	26	human	human	NOUN
admet-291	125	27	)	)	PUNCT
admet-291	125	28	(	(	PUNCT
admet-291	125	29	log	log	NOUN
admet-291	125	30	l	l	PROPN
admet-291	125	31	/	/	SYM
admet-291	125	32	kg	kg	NOUN
admet-291	125	33	)	)	PUNCT
admet-291	125	34	fraction	fraction	NOUN
admet-291	125	35	unbound	unbound	NOUN
admet-291	125	36	(	(	PUNCT
admet-291	125	37	human	human	NOUN
admet-291	125	38	)	)	PUNCT
admet-291	125	39	p	p	NOUN
admet-291	125	40	-	-	PUNCT
admet-291	125	41	gp	gp	NOUN
admet-291	125	42	substrate	substrate	NOUN
admet-291	125	43	(	(	PUNCT
admet-291	125	44	yes	yes	INTJ
admet-291	125	45	/	/	SYM
admet-291	125	46	no	no	NOUN
admet-291	125	47	)	)	PUNCT
admet-291	125	48	13	13	NUM
admet-291	125	49	-	-	PUNCT
admet-291	125	50	epi	epi	NOUN
admet-291	125	51	-	-	NOUN
admet-291	125	52	sclareol	sclareol	ADJ
admet-291	125	53	-0.791	-0.791	ADJ
admet-291	125	54	28.495	28.495	NUM
admet-291	125	55	-1.597	-1.597	NUM
admet-291	125	56	0.419	0.419	NUM
admet-291	125	57	yes	yes	NOUN
admet-291	125	58	6	6	NUM
admet-291	125	59	-	-	PUNCT
admet-291	125	60	gingerol	gingerol	VERB
admet-291	125	61	0.959	0.959	NUM
admet-291	125	62	93.293	93.293	NUM
admet-291	125	63	-0.061	-0.061	NOUN
admet-291	125	64	0.248	0.248	NUM
admet-291	125	65	yes	yes	NOUN
admet-291	125	66	ahwagandhanolide	ahwagandhanolide	ADV
admet-291	125	67	0.197	0.197	NUM
admet-291	125	68	82.511	82.511	NUM
admet-291	125	69	-0.244	-0.244	ADP
admet-291	125	70	0.112	0.112	NUM
admet-291	125	71	yes	yes	NOUN
admet-291	125	72	allicin	allicin	NOUN
admet-291	125	73	1.366	1.366	NUM
admet-291	125	74	98.525	98.525	NUM
admet-291	125	75	0.084	0.084	NUM
admet-291	125	76	0.502	0.502	NUM
admet-291	126	1	no	no	DET
admet-291	126	2	anethol	anethol	NOUN
admet-291	126	3	1.391	1.391	NUM
admet-291	126	4	98.814	98.814	NUM
admet-291	126	5	0.066	0.066	NUM
admet-291	126	6	0.322	0.322	NUM
admet-291	126	7	no	no	DET
admet-291	126	8	berberine	berberine	NOUN
admet-291	126	9	1.732	1.732	NUM
admet-291	126	10	100	100	NUM
admet-291	126	11	0.134	0.134	NUM
admet-291	126	12	0.196	0.196	NUM
admet-291	127	1	no	no	DET
admet-291	127	2	beta	beta	ADJ
admet-291	127	3	carotene	carotene	NOUN
admet-291	127	4	1.397	1.397	NUM
admet-291	127	5	91.234	91.234	NUM
admet-291	127	6	1.319	1.319	NUM
admet-291	127	7	0	0	NUM
admet-291	128	1	no	no	DET
admet-291	128	2	betulinic	betulinic	ADJ
admet-291	128	3	acid	acid	NOUN
admet-291	128	4	1.294	1.294	NUM
admet-291	128	5	91.58	91.58	NUM
admet-291	128	6	0.418	0.418	NUM
admet-291	128	7	0	0	PUNCT
admet-291	129	1	yes	yes	INTJ
admet-291	129	2	capsaicin	capsaicin	NOUN
admet-291	129	3	1.429	1.429	NUM
admet-291	129	4	92.542	92.542	NUM
admet-291	129	5	0.084	0.084	NUM
admet-291	129	6	0.172	0.172	NUM
admet-291	129	7	yes	yes	NOUN
admet-291	129	8	catechins	catechin	NOUN
admet-291	129	9	-0.38	-0.38	PROPN
admet-291	129	10	71.562	71.562	NUM
admet-291	129	11	-0.79	-0.79	NUM
admet-291	129	12	0.326	0.326	NUM
admet-291	129	13	yes	yes	INTJ
admet-291	129	14	corchorusin	corchorusin	NOUN
admet-291	129	15	-	-	PUNCT
admet-291	129	16	d	d	NOUN
admet-291	129	17	-0.193	-0.193	NUM
admet-291	129	18	55.926	55.926	NUM
admet-291	129	19	-0.401	-0.401	NUM
admet-291	130	1	0.318	0.318	NUM
admet-291	130	2	yes	yes	INTJ
admet-291	130	3	curcumin	curcumin	VERB
admet-291	130	4	0.556	0.556	NUM
admet-291	130	5	81.7	81.7	NUM
admet-291	130	6	-0.677	-0.677	NUM
admet-291	130	7	0.103	0.103	NUM
admet-291	130	8	yes	yes	INTJ
admet-291	130	9	diallyl	diallyl	VERB
admet-291	130	10	sulfide	sulfide	NOUN
admet-291	130	11	1.252	1.252	NUM
admet-291	130	12	98.6	98.6	NUM
admet-291	130	13	0.282	0.282	NUM
admet-291	130	14	0.487	0.487	NUM
admet-291	131	1	no	no	PRON
admet-291	131	2	diosgenin	diosgenin	VERB
admet-291	131	3	1.245	1.245	NUM
admet-291	131	4	96.426	96.426	NUM
admet-291	131	5	0.931	0.931	NUM
admet-291	131	6	0.09	0.09	NUM
admet-291	131	7	yes	yes	INTJ
admet-291	131	8	ellagic	ellagic	ADJ
admet-291	131	9	acid	acid	NOUN
admet-291	131	10	-0.273	-0.273	NUM
admet-291	131	11	80.032	80.032	NUM
admet-291	131	12	-1.214	-1.214	NUM
admet-291	131	13	0.27	0.27	NUM
admet-291	132	1	yes	yes	INTJ
admet-291	133	1	eugenol	eugenol	PROPN
admet-291	133	2	1.48	1.48	NUM
admet-291	133	3	96.594	96.594	NUM
admet-291	133	4	-0.071	-0.071	NOUN
admet-291	133	5	0.375	0.375	NUM
admet-291	133	6	no	no	DET
admet-291	133	7	genistein	genistein	NOUN
admet-291	133	8	1.07	1.07	NUM
admet-291	133	9	90.14	90.14	NUM
admet-291	133	10	-0.836	-0.836	NOUN
admet-291	133	11	0.192	0.192	NUM
admet-291	133	12	yes	yes	NUM
admet-291	133	13	indole-3	indole-3	NOUN
admet-291	133	14	-	-	PUNCT
admet-291	133	15	carbinol	carbinol	ADJ
admet-291	133	16	1.31	1.31	NUM
admet-291	133	17	94.062	94.062	NUM
admet-291	133	18	-0.027	-0.027	NUM
admet-291	133	19	0.406	0.406	NUM
admet-291	133	20	no	no	DET
admet-291	133	21	limonen	limonen	NOUN
admet-291	133	22	1.248	1.248	NUM
admet-291	133	23	98.048	98.048	NUM
admet-291	133	24	0.503	0.503	NUM
admet-291	133	25	0.422	0.422	NUM
admet-291	133	26	no	no	DET
admet-291	133	27	longimide	longimide	ADJ
admet-291	133	28	1.02	1.02	NUM
admet-291	133	29	89.104	89.104	NUM
admet-291	133	30	0.525	0.525	NUM
admet-291	133	31	0	0	NUM
admet-291	134	1	yes	yes	INTJ
admet-291	134	2	longitriol	longitriol	VERB
admet-291	134	3	1.277	1.277	NUM
admet-291	134	4	90.662	90.662	NUM
admet-291	134	5	0.857	0.857	NUM
admet-291	134	6	0	0	NUM
admet-291	135	1	yes	yes	PRON
admet-291	135	2	lycopene	lycopene	VERB
admet-291	135	3	1.444	1.444	NUM
admet-291	135	4	90.326	90.326	NUM
admet-291	135	5	1.115	1.115	NUM
admet-291	135	6	0	0	NUM
admet-291	136	1	no	no	DET
admet-291	136	2	methyl	methyl	NOUN
admet-291	136	3	anolensate	anolensate	ADJ
admet-291	136	4	1.241	1.241	NUM
admet-291	136	5	100	100	NUM
admet-291	136	6	0.04	0.04	NUM
admet-291	136	7	0.14	0.14	NUM
admet-291	136	8	yes	yes	NOUN
admet-291	136	9	resveratrol	resveratrol	VERB
admet-291	136	10	1.294	1.294	NUM
admet-291	136	11	89.885	89.885	NUM
admet-291	136	12	-0.403	-0.403	NOUN
admet-291	136	13	0.198	0.198	NUM
admet-291	136	14	no	no	PRON
admet-291	136	15	s	s	NOUN
admet-291	136	16	-	-	PUNCT
admet-291	136	17	allyl	allyl	ADJ
admet-291	136	18	cyteine	cyteine	NOUN
admet-291	136	19	0.375	0.375	NUM
admet-291	136	20	88.593	88.593	NUM
admet-291	136	21	0.026	0.026	NUM
admet-291	136	22	0.711	0.711	NUM
admet-291	136	23	no	no	DET
admet-291	136	24	silymarin	silymarin	NOUN
admet-291	136	25	-0.363	-0.363	PUNCT
admet-291	136	26	74.315	74.315	NUM
admet-291	136	27	-1.327	-1.327	NOUN
admet-291	136	28	0.142	0.142	NUM
admet-291	136	29	yes	yes	INTJ
admet-291	136	30	withaferin	withaferin	NOUN
admet-291	136	31	a	a	DET
admet-291	136	32	1.475	1.475	NUM
admet-291	136	33	95.986	95.986	NUM
admet-291	136	34	0.337	0.337	NUM
admet-291	136	35	0.171	0.171	NUM
admet-291	137	1	yes	yes	INTJ
admet-291	137	2	drugs	drug	NOUN
admet-291	137	3	camptothecin	camptothecin	VERB
admet-291	137	4	1.118	1.118	NUM
admet-291	137	5	99.412	99.412	NUM
admet-291	137	6	-0.694	-0.694	NOUN
admet-291	137	7	0.195	0.195	NUM
admet-291	137	8	yes	yes	INTJ
admet-291	137	9	docetaxel	docetaxel	NOUN
admet-291	137	10	-0.337	-0.337	NOUN
admet-291	138	1	62.988	62.988	NUM
admet-291	138	2	-1.068	-1.068	NUM
admet-291	138	3	0.138	0.138	NUM
admet-291	138	4	yes	yes	INTJ
admet-291	138	5	etoposide	etoposide	NOUN
admet-291	138	6	-0.32	-0.32	VERB
admet-291	138	7	82.748	82.748	NUM
admet-291	138	8	-1.185	-1.185	NUM
admet-291	138	9	0.194	0.194	NUM
admet-291	139	1	yes	yes	INTJ
admet-291	139	2	irinotecan	irinotecan	NOUN
admet-291	139	3	0.986	0.986	NUM
admet-291	139	4	93.659	93.659	NUM
admet-291	139	5	-0.036	-0.036	NOUN
admet-291	139	6	0.179	0.179	NUM
admet-291	139	7	yes	yes	INTJ
admet-291	139	8	paclitaxel	paclitaxel	NOUN
admet-291	139	9	-0.239	-0.239	PUNCT
admet-291	139	10	71.535	71.535	NUM
admet-291	139	11	-1.08	-1.08	NUM
admet-291	139	12	0.105	0.105	NUM
admet-291	139	13	yes	yes	NOUN
admet-291	139	14	teniposide	teniposide	NOUN
admet-291	139	15	-0.255	-0.255	PUNCT
admet-291	139	16	90.274	90.274	NUM
admet-291	139	17	-1.267	-1.267	NUM
admet-291	139	18	0.098	0.098	NUM
admet-291	140	1	yes	yes	NOUN
admet-291	140	2	topotecan	topotecan	NOUN
admet-291	140	3	0.668	0.668	NUM
admet-291	140	4	83.641	83.641	NUM
admet-291	140	5	-0.21	-0.21	NUM
admet-291	140	6	0.31	0.31	NUM
admet-291	140	7	yes	yes	INTJ
admet-291	140	8	vinblastine	vinblastine	NOUN
admet-291	140	9	0.257	0.257	NUM
admet-291	140	10	81.36	81.36	NUM
admet-291	140	11	0.123	0.123	NUM
admet-291	140	12	0.241	0.241	NUM
admet-291	140	13	yes	yes	NOUN
admet-291	140	14	vincristine	vincristine	NOUN
admet-291	140	15	0.186	0.186	NUM
admet-291	140	16	78.558	78.558	NUM
admet-291	140	17	-0.034	-0.034	NUM
admet-291	140	18	0.261	0.261	NUM
admet-291	141	1	yes	yes	INTJ
admet-291	141	2	vinorelbine	vinorelbine	VERB
admet-291	141	3	1.413	1.413	NUM
admet-291	141	4	90.783	90.783	NUM
admet-291	141	5	0.282	0.282	NUM
admet-291	141	6	0.193	0.193	NUM
admet-291	141	7	yes	yes	INTJ
admet-291	141	8	abiraterone	abiraterone	NOUN
admet-291	141	9	1.20	1.20	NUM
admet-291	141	10	98.16	98.16	NUM
admet-291	141	11	0.67	0.67	NUM
admet-291	141	12	0.05	0.05	NUM
admet-291	142	1	yes	yes	NOUN
admet-291	142	2	amrubicin	amrubicin	NOUN
admet-291	142	3	-0.26	-0.26	PRON
admet-291	142	4	66.22	66.22	NUM
admet-291	142	5	-0.48	-0.48	NUM
admet-291	142	6	0.38	0.38	NUM
admet-291	143	1	yes	yes	INTJ
admet-291	143	2	arglabin	arglabin	ADJ
admet-291	143	3	1.59	1.59	NUM
admet-291	143	4	100.00	100.00	NUM
admet-291	143	5	0.49	0.49	NUM
admet-291	143	6	0.41	0.41	NUM
admet-291	143	7	yes	yes	NOUN
admet-291	143	8	carfilzomib	carfilzomib	NOUN
admet-291	143	9	0.26	0.26	NUM
admet-291	143	10	52.92	52.92	NUM
admet-291	143	11	0.01	0.01	NUM
admet-291	143	12	0.23	0.23	NUM
admet-291	143	13	yes	yes	INTJ
admet-291	143	14	combretastatin	combretastatin	PROPN
admet-291	143	15	1.06	1.06	NUM
admet-291	143	16	94.13	94.13	NUM
admet-291	143	17	-0.71	-0.71	NOUN
admet-291	143	18	0.21	0.21	NUM
admet-291	144	1	yes	yes	INTJ
admet-291	144	2	ellipticine	ellipticine	PROPN
admet-291	144	3	1.35	1.35	NUM
admet-291	144	4	94.47	94.47	NUM
admet-291	144	5	-0.15	-0.15	NUM
admet-291	144	6	0.09	0.09	NUM
admet-291	144	7	yes	yes	INTJ
admet-291	144	8	exemestane	exemestane	NOUN
admet-291	144	9	1.52	1.52	NUM
admet-291	144	10	100.00	100.00	NUM
admet-291	144	11	0.69	0.69	NUM
admet-291	144	12	0.18	0.18	NUM
admet-291	145	1	yes	yes	INTJ
admet-291	145	2	formestane	formestane	ADJ
admet-291	145	3	1.39	1.39	NUM
admet-291	145	4	96.29	96.29	NUM
admet-291	145	5	0.50	0.50	NUM
admet-291	145	6	0.21	0.21	NUM
admet-291	145	7	yes	yes	INTJ
admet-291	145	8	homoharringtonine	homoharringtonine	NOUN
admet-291	145	9	0.57	0.57	NUM
admet-291	145	10	79.16	79.16	NUM
admet-291	145	11	0.11	0.11	NUM
admet-291	145	12	0.35	0.35	NUM
admet-291	146	1	yes	yes	INTJ
admet-291	146	2	podophyllotoxin	podophyllotoxin	VERB
admet-291	146	3	0.78	0.78	NUM
admet-291	146	4	95.31	95.31	NUM
admet-291	146	5	-0.82	-0.82	NUM
admet-291	146	6	0.13	0.13	NUM
admet-291	146	7	yes	yes	INTJ
admet-291	146	8	rohitukine	rohitukine	VERB
admet-291	146	9	-0.22	-0.22	NUM
admet-291	146	10	73.76	73.76	NUM
admet-291	146	11	0.18	0.18	NUM
admet-291	146	12	0.49	0.49	NUM
admet-291	146	13	yes	yes	INTJ
admet-291	146	14	roscovitine	roscovitine	VERB
admet-291	146	15	1.01	1.01	NUM
admet-291	146	16	90.21	90.21	NUM
admet-291	146	17	1.97	1.97	NUM
admet-291	146	18	0.59	0.59	NUM
admet-291	147	1	yes	yes	INTJ
admet-291	147	2	vindesine	vindesine	VERB
admet-291	147	3	0.36	0.36	NUM
admet-291	147	4	70.43	70.43	NUM
admet-291	147	5	0.24	0.24	NUM
admet-291	147	6	0.29	0.29	NUM
admet-291	147	7	yes	yes	PRON
admet-291	147	8	vinflunine	vinflunine	NOUN
admet-291	147	9	1.31	1.31	NUM
admet-291	147	10	91.20	91.20	NUM
admet-291	147	11	0.16	0.16	NUM
admet-291	147	12	0.19	0.19	NUM
admet-291	148	1	yes	yes	INTJ
admet-291	148	2	deepika	deepika	PROPN
admet-291	148	3	singh	singh	PROPN
admet-291	148	4	admet	admet	PROPN
admet-291	148	5	&	&	CCONJ
admet-291	148	6	dmpk	dmpk	PROPN
admet-291	148	7	4(2	4(2	NUM
admet-291	148	8	)	)	PUNCT
admet-291	148	9	(	(	PUNCT
admet-291	148	10	2016	2016	NUM
admet-291	148	11	)	)	PUNCT
admet-291	148	12	98	98	NUM
admet-291	148	13	-	-	SYM
admet-291	148	14	113	113	NUM
admet-291	148	15	108	108	NUM
admet-291	148	16	in	in	ADP
admet-291	148	17	order	order	NOUN
admet-291	148	18	to	to	PART
admet-291	148	19	understand	understand	VERB
admet-291	148	20	the	the	DET
admet-291	148	21	effect	effect	NOUN
admet-291	148	22	of	of	ADP
admet-291	148	23	physicochemical	physicochemical	ADJ
admet-291	148	24	properties	property	NOUN
admet-291	148	25	on	on	ADP
admet-291	148	26	adme	adme	NOUN
admet-291	148	27	attributes	attribute	NOUN
admet-291	148	28	of	of	ADP
admet-291	148	29	the	the	DET
admet-291	148	30	molecules	molecule	NOUN
admet-291	148	31	,	,	PUNCT
admet-291	148	32	we	we	PRON
admet-291	148	33	analyzed	analyze	VERB
admet-291	148	34	adme	adme	NOUN
admet-291	148	35	attributes	attribute	VERB
admet-291	148	36	for	for	ADP
admet-291	148	37	both	both	DET
admet-291	148	38	drugs	drug	NOUN
admet-291	148	39	and	and	CCONJ
admet-291	148	40	leads	lead	VERB
admet-291	148	41	against	against	ADP
admet-291	148	42	all	all	DET
admet-291	148	43	eight	eight	NUM
admet-291	148	44	fundamental	fundamental	ADJ
admet-291	148	45	physicochemical	physicochemical	ADJ
admet-291	148	46	properties	property	NOUN
admet-291	148	47	.	.	PUNCT
admet-291	149	1	interestingly	interestingly	ADV
admet-291	149	2	,	,	PUNCT
admet-291	149	3	tpsa	tpsa	PROPN
admet-291	149	4	,	,	PUNCT
admet-291	149	5	hbd	hbd	NOUN
admet-291	149	6	,	,	PUNCT
admet-291	149	7	and	and	CCONJ
admet-291	149	8	hba	hba	NOUN
admet-291	149	9	showed	show	VERB
admet-291	149	10	good	good	ADJ
admet-291	149	11	correlation	correlation	NOUN
admet-291	149	12	with	with	ADP
admet-291	149	13	the	the	DET
admet-291	149	14	caco2	caco2	NOUN
admet-291	149	15	cell	cell	NOUN
admet-291	149	16	permeability	permeability	NOUN
admet-291	149	17	,	,	PUNCT
admet-291	149	18	with	with	ADP
admet-291	149	19	the	the	DET
admet-291	149	20	correlation	correlation	NOUN
admet-291	149	21	coefficient	coefficient	NOUN
admet-291	149	22	of	of	ADP
admet-291	149	23	0.83	0.83	NUM
admet-291	149	24	,	,	PUNCT
admet-291	149	25	0.8	0.8	NUM
admet-291	149	26	,	,	PUNCT
admet-291	149	27	and	and	CCONJ
admet-291	149	28	0.7	0.7	NUM
admet-291	149	29	respectively	respectively	ADV
admet-291	149	30	for	for	ADP
admet-291	149	31	the	the	DET
admet-291	149	32	drug	drug	NOUN
admet-291	149	33	molecules	molecule	NOUN
admet-291	149	34	.	.	PUNCT
admet-291	150	1	similarly	similarly	ADV
admet-291	150	2	,	,	PUNCT
admet-291	150	3	anticancer	anticancer	NOUN
admet-291	150	4	leads	lead	NOUN
admet-291	150	5	also	also	ADV
admet-291	150	6	showed	show	VERB
admet-291	150	7	slightly	slightly	ADV
admet-291	150	8	better	well	ADJ
admet-291	150	9	correlation	correlation	NOUN
admet-291	150	10	of	of	ADP
admet-291	150	11	physicochemical	physicochemical	ADJ
admet-291	150	12	properties	property	NOUN
admet-291	150	13	tpsa	tpsa	VERB
admet-291	150	14	,	,	PUNCT
admet-291	150	15	hbd	hbd	NOUN
admet-291	150	16	and	and	CCONJ
admet-291	150	17	hba	hba	NOUN
admet-291	150	18	with	with	ADP
admet-291	150	19	caco2	caco2	NOUN
admet-291	150	20	cell	cell	NOUN
admet-291	150	21	permeability	permeability	NOUN
admet-291	150	22	,	,	PUNCT
admet-291	150	23	with	with	ADP
admet-291	150	24	the	the	DET
admet-291	150	25	correlation	correlation	NOUN
admet-291	150	26	coefficient	coefficient	NOUN
admet-291	150	27	of	of	ADP
admet-291	150	28	0.83	0.83	NUM
admet-291	150	29	,	,	PUNCT
admet-291	150	30	0.84	0.84	NUM
admet-291	150	31	,	,	PUNCT
admet-291	150	32	and	and	CCONJ
admet-291	150	33	0.78	0.78	NUM
admet-291	150	34	,	,	PUNCT
admet-291	150	35	respectively	respectively	ADV
admet-291	150	36	.	.	PUNCT
admet-291	151	1	although	although	SCONJ
admet-291	151	2	,	,	PUNCT
admet-291	151	3	all	all	DET
admet-291	151	4	three	three	NUM
admet-291	151	5	physicochemical	physicochemical	ADJ
admet-291	151	6	properties	property	NOUN
admet-291	151	7	(	(	PUNCT
admet-291	151	8	tpsa	tpsa	PROPN
admet-291	151	9	,	,	PUNCT
admet-291	151	10	hbd	hbd	NOUN
admet-291	151	11	,	,	PUNCT
admet-291	151	12	hba	hba	PROPN
admet-291	151	13	)	)	PUNCT
admet-291	151	14	are	be	AUX
admet-291	151	15	inversely	inversely	ADV
admet-291	151	16	correlated	correlate	VERB
admet-291	151	17	with	with	ADP
admet-291	151	18	the	the	DET
admet-291	151	19	caco2	caco2	NOUN
admet-291	151	20	cell	cell	NOUN
admet-291	151	21	permeability	permeability	NOUN
admet-291	151	22	suggesting	suggest	VERB
admet-291	151	23	that	that	SCONJ
admet-291	151	24	lipophilicity	lipophilicity	NOUN
admet-291	151	25	is	be	AUX
admet-291	151	26	important	important	ADJ
admet-291	151	27	for	for	SCONJ
admet-291	151	28	molecule	molecule	NOUN
admet-291	151	29	to	to	PART
admet-291	151	30	have	have	VERB
admet-291	151	31	good	good	ADJ
admet-291	151	32	caco2	caco2	NOUN
admet-291	151	33	cell	cell	NOUN
admet-291	151	34	permeability	permeability	NOUN
admet-291	151	35	and	and	CCONJ
admet-291	151	36	by	by	ADP
admet-291	151	37	optimizing	optimize	VERB
admet-291	151	38	the	the	DET
admet-291	151	39	tpsa	tpsa	NOUN
admet-291	151	40	,	,	PUNCT
admet-291	151	41	hbd	hbd	NOUN
admet-291	151	42	,	,	PUNCT
admet-291	151	43	and	and	CCONJ
admet-291	151	44	hba	hba	NOUN
admet-291	151	45	cell	cell	NOUN
admet-291	151	46	permeability	permeability	NOUN
admet-291	151	47	of	of	ADP
admet-291	151	48	a	a	DET
admet-291	151	49	molecule	molecule	NOUN
admet-291	151	50	can	can	AUX
admet-291	151	51	be	be	AUX
admet-291	151	52	enhanced	enhance	VERB
admet-291	151	53	.	.	PUNCT
admet-291	152	1	human	human	ADJ
admet-291	152	2	intestinal	intestinal	ADJ
admet-291	152	3	absorption	absorption	NOUN
admet-291	152	4	also	also	ADV
admet-291	152	5	showed	show	VERB
admet-291	152	6	good	good	ADJ
admet-291	152	7	correlation	correlation	NOUN
admet-291	152	8	with	with	ADP
admet-291	152	9	the	the	DET
admet-291	152	10	hbd	hbd	NOUN
admet-291	152	11	,	,	PUNCT
admet-291	152	12	tpsa	tpsa	NOUN
admet-291	152	13	,	,	PUNCT
admet-291	152	14	and	and	CCONJ
admet-291	152	15	hba	hba	VERB
admet-291	152	16	physicochemical	physicochemical	ADJ
admet-291	152	17	properties	property	NOUN
admet-291	152	18	for	for	ADP
admet-291	152	19	both	both	DET
admet-291	152	20	anticancer	anticancer	NOUN
admet-291	152	21	drug	drug	NOUN
admet-291	152	22	and	and	CCONJ
admet-291	152	23	lead	lead	ADJ
admet-291	152	24	molecules	molecule	NOUN
admet-291	152	25	.	.	PUNCT
admet-291	153	1	the	the	DET
admet-291	153	2	correlation	correlation	NOUN
admet-291	153	3	coefficient	coefficient	NOUN
admet-291	153	4	of	of	ADP
admet-291	153	5	%	%	PROPN
admet-291	153	6	human	human	ADJ
admet-291	153	7	intestinal	intestinal	ADJ
admet-291	153	8	absorption	absorption	NOUN
admet-291	153	9	with	with	ADP
admet-291	153	10	hbd	hbd	PROPN
admet-291	153	11	,	,	PUNCT
admet-291	153	12	tpsa	tpsa	PROPN
admet-291	153	13	,	,	PUNCT
admet-291	153	14	and	and	CCONJ
admet-291	153	15	hba	hba	NOUN
admet-291	153	16	was	be	AUX
admet-291	153	17	0.88	0.88	NUM
admet-291	153	18	,	,	PUNCT
admet-291	153	19	0.74	0.74	NUM
admet-291	153	20	,	,	PUNCT
admet-291	153	21	and	and	CCONJ
admet-291	153	22	0.67	0.67	NUM
admet-291	153	23	respectively	respectively	ADV
admet-291	153	24	for	for	ADP
admet-291	153	25	drugs	drug	NOUN
admet-291	153	26	and	and	CCONJ
admet-291	153	27	0.91	0.91	NUM
admet-291	153	28	,	,	PUNCT
admet-291	153	29	0.81	0.81	NUM
admet-291	153	30	,	,	PUNCT
admet-291	153	31	and	and	CCONJ
admet-291	153	32	0.8	0.8	NUM
admet-291	153	33	respectively	respectively	ADV
admet-291	153	34	for	for	ADP
admet-291	153	35	leads	lead	NOUN
admet-291	153	36	.	.	PUNCT
admet-291	154	1	this	this	DET
admet-291	154	2	results	result	NOUN
admet-291	154	3	clearly	clearly	ADV
admet-291	154	4	revealed	reveal	VERB
admet-291	154	5	the	the	DET
admet-291	154	6	influence	influence	NOUN
admet-291	154	7	of	of	ADP
admet-291	154	8	physicochemical	physicochemical	ADJ
admet-291	154	9	properties	property	NOUN
admet-291	154	10	on	on	ADP
admet-291	154	11	adme	adme	NOUN
admet-291	154	12	attributes	attribute	NOUN
admet-291	154	13	of	of	ADP
admet-291	154	14	the	the	DET
admet-291	154	15	molecule	molecule	NOUN
admet-291	154	16	for	for	ADP
admet-291	154	17	oral	oral	ADJ
admet-291	154	18	bioavailability	bioavailability	NOUN
admet-291	154	19	and	and	CCONJ
admet-291	154	20	the	the	DET
admet-291	154	21	key	key	ADJ
admet-291	154	22	physicochemical	physicochemical	ADJ
admet-291	154	23	properties	property	NOUN
admet-291	154	24	especially	especially	ADV
admet-291	154	25	hba	hba	NOUN
admet-291	154	26	,	,	PUNCT
admet-291	154	27	hbd	hbd	NOUN
admet-291	154	28	,	,	PUNCT
admet-291	154	29	and	and	CCONJ
admet-291	154	30	tpsa	tpsa	NOUN
admet-291	154	31	need	need	VERB
admet-291	154	32	to	to	PART
admet-291	154	33	be	be	AUX
admet-291	154	34	consider	consider	VERB
admet-291	154	35	for	for	ADP
admet-291	154	36	further	further	ADJ
admet-291	154	37	improvement	improvement	NOUN
admet-291	154	38	in	in	ADP
admet-291	154	39	the	the	DET
admet-291	154	40	adme	adme	NOUN
admet-291	154	41	profile	profile	NOUN
admet-291	154	42	of	of	ADP
admet-291	154	43	natural	natural	ADJ
admet-291	154	44	product	product	NOUN
admet-291	154	45	derived	derive	VERB
admet-291	154	46	anticancer	anticancer	NOUN
admet-291	154	47	leads	lead	VERB
admet-291	154	48	.	.	PUNCT
admet-291	155	1	determining	determine	VERB
admet-291	155	2	potential	potential	ADJ
admet-291	155	3	safety	safety	NOUN
admet-291	155	4	end	end	NOUN
admet-291	155	5	points	point	NOUN
admet-291	155	6	for	for	ADP
admet-291	155	7	anticancer	anticancer	NOUN
admet-291	155	8	molecules	molecule	NOUN
admet-291	155	9	early	early	ADJ
admet-291	155	10	prediction	prediction	NOUN
admet-291	155	11	of	of	ADP
admet-291	155	12	the	the	DET
admet-291	155	13	safety	safety	NOUN
admet-291	155	14	endpoints	endpoint	NOUN
admet-291	155	15	through	through	ADP
admet-291	155	16	in	in	ADP
admet-291	155	17	silico	silico	NOUN
admet-291	155	18	techniques	technique	NOUN
admet-291	155	19	screening	screening	NOUN
admet-291	155	20	have	have	AUX
admet-291	155	21	become	become	VERB
admet-291	155	22	regular	regular	ADJ
admet-291	155	23	practice	practice	NOUN
admet-291	155	24	for	for	ADP
admet-291	155	25	both	both	PRON
admet-291	155	26	designing	design	VERB
admet-291	155	27	new	new	ADJ
admet-291	155	28	molecule	molecule	NOUN
admet-291	155	29	and	and	CCONJ
admet-291	155	30	screening	screening	NOUN
admet-291	155	31	of	of	ADP
admet-291	155	32	the	the	DET
admet-291	155	33	large	large	ADJ
admet-291	155	34	chemical	chemical	NOUN
admet-291	155	35	databases	database	NOUN
admet-291	155	36	within	within	ADP
admet-291	155	37	pharmaceutical	pharmaceutical	ADJ
admet-291	155	38	industries	industry	NOUN
admet-291	155	39	[	[	X
admet-291	155	40	25	25	NUM
admet-291	155	41	]	]	PUNCT
admet-291	155	42	.	.	PUNCT
admet-291	156	1	as	as	ADP
admet-291	156	2	part	part	NOUN
admet-291	156	3	of	of	ADP
admet-291	156	4	our	our	PRON
admet-291	156	5	analysis	analysis	NOUN
admet-291	156	6	of	of	ADP
admet-291	156	7	properties	property	NOUN
admet-291	156	8	for	for	ADP
admet-291	156	9	anticancer	anticancer	NOUN
admet-291	156	10	drugs	drug	NOUN
admet-291	156	11	and	and	CCONJ
admet-291	156	12	lead	lead	ADJ
admet-291	156	13	candidates	candidate	NOUN
admet-291	156	14	,	,	PUNCT
admet-291	156	15	we	we	PRON
admet-291	156	16	determine	determine	VERB
admet-291	156	17	the	the	DET
admet-291	156	18	potential	potential	ADJ
admet-291	156	19	toxicity	toxicity	NOUN
admet-291	156	20	end	end	NOUN
admet-291	156	21	points	point	NOUN
admet-291	156	22	for	for	ADP
admet-291	156	23	through	through	ADP
admet-291	156	24	pkcsm	pkcsm	NOUN
admet-291	156	25	.	.	PUNCT
admet-291	157	1	most	most	ADV
admet-291	157	2	frequently	frequently	ADV
admet-291	157	3	measured	measure	VERB
admet-291	157	4	end	end	NOUN
admet-291	157	5	points	point	NOUN
admet-291	157	6	to	to	PART
admet-291	157	7	evaluate	evaluate	VERB
admet-291	157	8	potential	potential	ADJ
admet-291	157	9	safety	safety	NOUN
admet-291	157	10	issues	issue	NOUN
admet-291	157	11	include	include	VERB
admet-291	157	12	inhibition	inhibition	NOUN
admet-291	157	13	of	of	ADP
admet-291	157	14	cytochrome	cytochrome	ADJ
admet-291	157	15	p450	p450	PROPN
admet-291	157	16	(	(	PUNCT
admet-291	157	17	cyps	cyps	PROPN
admet-291	157	18	)	)	PUNCT
admet-291	157	19	monooxygenase	monooxygenase	NOUN
admet-291	157	20	enzymes	enzyme	NOUN
admet-291	157	21	to	to	PART
admet-291	157	22	determine	determine	VERB
admet-291	157	23	potential	potential	NOUN
admet-291	157	24	for	for	ADP
admet-291	157	25	drug	drug	NOUN
admet-291	157	26	-	-	PUNCT
admet-291	157	27	drug	drug	NOUN
admet-291	157	28	interactions	interaction	NOUN
admet-291	157	29	[	[	X
admet-291	157	30	26	26	NUM
admet-291	157	31	]	]	PUNCT
admet-291	157	32	,	,	PUNCT
admet-291	157	33	inhibition	inhibition	NOUN
admet-291	157	34	of	of	ADP
admet-291	157	35	herg	herg	PROPN
admet-291	157	36	potassium	potassium	NOUN
admet-291	157	37	ion	ion	NOUN
admet-291	157	38	channel	channel	NOUN
admet-291	157	39	effects	effect	NOUN
admet-291	157	40	[	[	X
admet-291	157	41	27	27	NUM
admet-291	157	42	]	]	PUNCT
admet-291	157	43	,	,	PUNCT
admet-291	157	44	lethal	lethal	ADJ
admet-291	157	45	rat	rat	NOUN
admet-291	157	46	acute	acute	NOUN
admet-291	157	47	toxicity	toxicity	NOUN
admet-291	157	48	(	(	PUNCT
admet-291	157	49	ld50	ld50	PROPN
admet-291	157	50	)	)	PUNCT
admet-291	157	51	and	and	CCONJ
admet-291	157	52	other	other	ADJ
admet-291	157	53	crucial	crucial	ADJ
admet-291	157	54	toxicity	toxicity	NOUN
admet-291	157	55	(	(	PUNCT
admet-291	157	56	ames	ame	NOUN
admet-291	157	57	toxicity	toxicity	NOUN
admet-291	157	58	,	,	PUNCT
admet-291	157	59	skin	skin	NOUN
admet-291	157	60	sensitization	sensitization	NOUN
admet-291	157	61	,	,	PUNCT
admet-291	157	62	and	and	CCONJ
admet-291	157	63	hepatotoxicity	hepatotoxicity	NOUN
admet-291	157	64	)	)	PUNCT
admet-291	157	65	.	.	PUNCT
admet-291	158	1	all	all	DET
admet-291	158	2	toxicity	toxicity	NOUN
admet-291	158	3	predictions	prediction	NOUN
admet-291	158	4	for	for	ADP
admet-291	158	5	both	both	DET
admet-291	158	6	drugs	drug	NOUN
admet-291	158	7	and	and	CCONJ
admet-291	158	8	lead	lead	ADJ
admet-291	158	9	candidates	candidate	NOUN
admet-291	158	10	are	be	AUX
admet-291	158	11	presented	present	VERB
admet-291	158	12	in	in	ADP
admet-291	158	13	table	table	NOUN
admet-291	158	14	3	3	NUM
admet-291	158	15	.	.	PUNCT
admet-291	159	1	we	we	PRON
admet-291	159	2	qualitatively	qualitatively	ADV
admet-291	159	3	predicted	predict	VERB
admet-291	159	4	the	the	DET
admet-291	159	5	inhibition	inhibition	NOUN
admet-291	159	6	of	of	ADP
admet-291	159	7	cyp2d6	cyp2d6	NOUN
admet-291	159	8	and	and	CCONJ
admet-291	159	9	cyp3a4	cyp3a4	NOUN
admet-291	159	10	through	through	ADP
admet-291	159	11	pkcsm	pkcsm	NOUN
admet-291	159	12	,	,	PUNCT
admet-291	159	13	which	which	PRON
admet-291	159	14	suggests	suggest	VERB
admet-291	159	15	the	the	DET
admet-291	159	16	potential	potential	NOUN
admet-291	159	17	for	for	ADP
admet-291	159	18	drugs	drug	NOUN
admet-291	159	19	and	and	CCONJ
admet-291	159	20	leads	lead	VERB
admet-291	159	21	candidates	candidate	NOUN
admet-291	159	22	to	to	PART
admet-291	159	23	mediate	mediate	VERB
admet-291	159	24	drug	drug	NOUN
admet-291	159	25	-	-	PUNCT
admet-291	159	26	drug	drug	NOUN
admet-291	159	27	interactions	interaction	NOUN
admet-291	159	28	(	(	PUNCT
admet-291	159	29	ddi	ddi	PROPN
admet-291	159	30	)	)	PUNCT
admet-291	159	31	through	through	ADP
admet-291	159	32	perturbation	perturbation	NOUN
admet-291	159	33	of	of	ADP
admet-291	159	34	clearance	clearance	NOUN
admet-291	159	35	mechanisms	mechanism	NOUN
admet-291	159	36	for	for	ADP
admet-291	159	37	other	other	ADJ
admet-291	159	38	drug	drug	NOUN
admet-291	159	39	substances	substance	NOUN
admet-291	159	40	.	.	PUNCT
admet-291	160	1	inhibition	inhibition	NOUN
admet-291	160	2	of	of	ADP
admet-291	160	3	the	the	DET
admet-291	160	4	potassium	potassium	NOUN
admet-291	160	5	herg	herg	PROPN
admet-291	160	6	channel	channel	NOUN
admet-291	160	7	might	might	AUX
admet-291	160	8	cause	cause	VERB
admet-291	160	9	in	in	ADP
admet-291	160	10	prolongation	prolongation	NOUN
admet-291	160	11	of	of	ADP
admet-291	160	12	the	the	DET
admet-291	160	13	qt	qt	NOUN
admet-291	160	14	interval	interval	NOUN
admet-291	160	15	of	of	ADP
admet-291	160	16	cardiac	cardiac	ADJ
admet-291	160	17	rhythm	rhythm	NOUN
admet-291	160	18	,	,	PUNCT
admet-291	160	19	which	which	PRON
admet-291	160	20	has	have	AUX
admet-291	160	21	resulted	result	VERB
admet-291	160	22	in	in	ADP
admet-291	160	23	the	the	DET
admet-291	160	24	withdrawal	withdrawal	NOUN
admet-291	160	25	of	of	ADP
admet-291	160	26	many	many	ADJ
admet-291	160	27	clinical	clinical	ADJ
admet-291	160	28	candidates	candidate	NOUN
admet-291	160	29	from	from	ADP
admet-291	160	30	the	the	DET
admet-291	160	31	market	market	NOUN
admet-291	160	32	[	[	X
admet-291	160	33	28	28	NUM
admet-291	160	34	]	]	PUNCT
admet-291	160	35	.	.	PUNCT
admet-291	161	1	therefore	therefore	ADV
admet-291	161	2	,	,	PUNCT
admet-291	161	3	we	we	PRON
admet-291	161	4	have	have	AUX
admet-291	161	5	qualitatively	qualitatively	ADV
admet-291	161	6	predicted	predict	VERB
admet-291	161	7	the	the	DET
admet-291	161	8	potassium	potassium	NOUN
admet-291	161	9	herg	herg	PROPN
admet-291	161	10	channel	channel	NOUN
admet-291	161	11	inhibition	inhibition	NOUN
admet-291	161	12	potential	potential	NOUN
admet-291	161	13	of	of	ADP
admet-291	161	14	drugs	drug	NOUN
admet-291	161	15	and	and	CCONJ
admet-291	161	16	lead	lead	ADJ
admet-291	161	17	candidates	candidate	NOUN
admet-291	161	18	.	.	PUNCT
admet-291	162	1	the	the	DET
admet-291	162	2	data	datum	NOUN
admet-291	162	3	obtained	obtain	VERB
admet-291	162	4	suggests	suggest	VERB
admet-291	162	5	that	that	SCONJ
admet-291	162	6	all	all	PRON
admet-291	162	7	of	of	ADP
admet-291	162	8	these	these	DET
admet-291	162	9	drugs	drug	NOUN
admet-291	162	10	and	and	CCONJ
admet-291	162	11	lead	lead	ADJ
admet-291	162	12	candidates	candidate	NOUN
admet-291	162	13	are	be	AUX
admet-291	162	14	non	non	ADJ
admet-291	162	15	-	-	ADJ
admet-291	162	16	inhibitor	inhibitor	NOUN
admet-291	162	17	of	of	ADP
admet-291	162	18	the	the	DET
admet-291	162	19	herg	herg	PROPN
admet-291	162	20	channel	channel	NOUN
admet-291	162	21	as	as	SCONJ
admet-291	162	22	mentioned	mention	VERB
admet-291	162	23	in	in	ADP
admet-291	162	24	table	table	NOUN
admet-291	162	25	3	3	NUM
admet-291	162	26	.	.	PUNCT
admet-291	162	27	analysis	analysis	NOUN
admet-291	162	28	of	of	ADP
admet-291	162	29	the	the	DET
admet-291	162	30	inhibition	inhibition	NOUN
admet-291	162	31	data	datum	NOUN
admet-291	162	32	of	of	ADP
admet-291	162	33	cyp2d6	cyp2d6	NOUN
admet-291	162	34	and	and	CCONJ
admet-291	162	35	cyp3a4	cyp3a4	PROPN
admet-291	162	36	revealed	reveal	VERB
admet-291	162	37	that	that	SCONJ
admet-291	162	38	all	all	DET
admet-291	162	39	the	the	DET
admet-291	162	40	drugs	drug	NOUN
admet-291	162	41	are	be	AUX
admet-291	162	42	non	non	ADJ
admet-291	162	43	-	-	ADJ
admet-291	162	44	inhibitor	inhibitor	NOUN
admet-291	162	45	of	of	ADP
admet-291	162	46	both	both	DET
admet-291	162	47	cyp	cyp	ADJ
admet-291	162	48	’s	’s	ADV
admet-291	162	49	and	and	CCONJ
admet-291	162	50	all	all	DET
admet-291	162	51	lead	lead	ADJ
admet-291	162	52	candidates	candidate	NOUN
admet-291	162	53	are	be	AUX
admet-291	162	54	non	non	ADJ
admet-291	162	55	-	-	ADJ
admet-291	162	56	inhibitor	inhibitor	NOUN
admet-291	162	57	of	of	ADP
admet-291	162	58	cyp2d6	cyp2d6	NOUN
admet-291	162	59	,	,	PUNCT
admet-291	162	60	while	while	SCONJ
admet-291	162	61	89	89	NUM
admet-291	162	62	%	%	NOUN
admet-291	162	63	of	of	ADP
admet-291	162	64	lead	lead	ADJ
admet-291	162	65	candidates	candidate	NOUN
admet-291	162	66	are	be	AUX
admet-291	162	67	non	non	ADJ
admet-291	162	68	-	-	ADJ
admet-291	162	69	inhibitor	inhibitor	NOUN
admet-291	162	70	of	of	ADP
admet-291	162	71	cyp3a4	cyp3a4	PROPN
admet-291	162	72	.	.	PUNCT
admet-291	163	1	this	this	DET
admet-291	163	2	data	data	NOUN
admet-291	163	3	suggests	suggest	VERB
admet-291	163	4	that	that	SCONJ
admet-291	163	5	most	most	ADJ
admet-291	163	6	of	of	ADP
admet-291	163	7	these	these	DET
admet-291	163	8	drugs	drug	NOUN
admet-291	163	9	and	and	CCONJ
admet-291	163	10	lead	lead	ADJ
admet-291	163	11	candidates	candidate	NOUN
admet-291	163	12	occupy	occupy	VERB
admet-291	163	13	desirable	desirable	ADJ
admet-291	163	14	,	,	PUNCT
admet-291	163	15	low	low	ADJ
admet-291	163	16	-	-	PUNCT
admet-291	163	17	risk	risk	NOUN
admet-291	163	18	space	space	NOUN
admet-291	163	19	for	for	ADP
admet-291	163	20	ddi	ddi	PROPN
admet-291	163	21	.	.	PUNCT
admet-291	163	22	drug	drug	NOUN
admet-291	163	23	metabolism	metabolism	NOUN
admet-291	163	24	and	and	CCONJ
admet-291	163	25	the	the	DET
admet-291	163	26	drug	drug	NOUN
admet-291	163	27	excretion	excretion	NOUN
admet-291	163	28	also	also	ADV
admet-291	163	29	have	have	VERB
admet-291	163	30	a	a	DET
admet-291	163	31	significant	significant	ADJ
admet-291	163	32	role	role	NOUN
admet-291	163	33	in	in	ADP
admet-291	163	34	the	the	DET
admet-291	163	35	drug	drug	NOUN
admet-291	163	36	design	design	NOUN
admet-291	163	37	process	process	NOUN
admet-291	163	38	.	.	PUNCT
admet-291	164	1	issues	issue	NOUN
admet-291	164	2	related	relate	VERB
admet-291	164	3	to	to	ADP
admet-291	164	4	metabolism	metabolism	NOUN
admet-291	164	5	have	have	AUX
admet-291	164	6	been	be	AUX
admet-291	164	7	commonly	commonly	ADV
admet-291	164	8	associated	associate	VERB
admet-291	164	9	with	with	ADP
admet-291	164	10	the	the	DET
admet-291	164	11	compounds	compound	NOUN
admet-291	164	12	failure	failure	NOUN
admet-291	164	13	in	in	ADP
admet-291	164	14	the	the	DET
admet-291	164	15	clinical	clinical	NOUN
admet-291	164	16	.	.	PUNCT
admet-291	165	1	understanding	understand	VERB
admet-291	165	2	the	the	DET
admet-291	165	3	metabolic	metabolic	NOUN
admet-291	165	4	pathways	pathway	NOUN
admet-291	165	5	of	of	ADP
admet-291	165	6	drugs	drug	NOUN
admet-291	165	7	would	would	AUX
admet-291	165	8	be	be	AUX
admet-291	165	9	very	very	ADV
admet-291	165	10	helpful	helpful	ADJ
admet-291	165	11	in	in	ADP
admet-291	165	12	predicting	predict	VERB
admet-291	165	13	drug	drug	NOUN
admet-291	165	14	-	-	PUNCT
admet-291	165	15	drug	drug	NOUN
admet-291	165	16	interactions	interaction	NOUN
admet-291	165	17	(	(	PUNCT
admet-291	165	18	ddi	ddi	PROPN
admet-291	165	19	)	)	PUNCT
admet-291	165	20	,	,	PUNCT
admet-291	165	21	toxicities	toxicity	NOUN
admet-291	165	22	,	,	PUNCT
admet-291	165	23	and	and	CCONJ
admet-291	165	24	pharmacokinetics	pharmacokinetic	NOUN
admet-291	165	25	[	[	X
admet-291	165	26	29	29	NUM
admet-291	165	27	]	]	PUNCT
admet-291	165	28	.	.	PUNCT
admet-291	166	1	many	many	ADJ
admet-291	166	2	relationships	relationship	NOUN
admet-291	166	3	between	between	ADP
admet-291	166	4	cyp	cyp	ADJ
admet-291	166	5	family	family	NOUN
admet-291	166	6	enzymes	enzyme	NOUN
admet-291	166	7	and	and	CCONJ
admet-291	166	8	in	in	ADP
admet-291	166	9	silico	silico	NOUN
admet-291	166	10	molecular	molecular	ADJ
admet-291	166	11	properties	property	NOUN
admet-291	166	12	have	have	AUX
admet-291	166	13	been	be	AUX
admet-291	166	14	available	available	ADJ
admet-291	166	15	in	in	ADP
admet-291	166	16	the	the	DET
admet-291	166	17	literature	literature	NOUN
admet-291	166	18	;	;	PUNCT
admet-291	166	19	the	the	DET
admet-291	166	20	primary	primary	ADJ
admet-291	166	21	concern	concern	NOUN
admet-291	166	22	is	be	AUX
admet-291	166	23	inhibition	inhibition	NOUN
admet-291	166	24	of	of	ADP
admet-291	166	25	cyp3a4	cyp3a4	NOUN
admet-291	166	26	,	,	PUNCT
admet-291	166	27	which	which	PRON
admet-291	166	28	is	be	AUX
admet-291	166	29	correlated	correlate	VERB
admet-291	166	30	to	to	ADP
admet-291	166	31	increasing	increase	VERB
admet-291	166	32	mw	mw	NOUN
admet-291	166	33	and	and	CCONJ
admet-291	166	34	log	log	VERB
admet-291	166	35	p	p	PROPN
admet-291	166	36	[	[	X
admet-291	166	37	30	30	NUM
admet-291	166	38	]	]	PUNCT
admet-291	166	39	.	.	PUNCT
admet-291	167	1	this	this	PRON
admet-291	167	2	may	may	AUX
admet-291	167	3	lead	lead	VERB
admet-291	167	4	to	to	ADP
admet-291	167	5	issues	issue	NOUN
admet-291	167	6	with	with	ADP
admet-291	167	7	clearance	clearance	NOUN
admet-291	167	8	as	as	ADV
admet-291	167	9	well	well	ADV
admet-291	167	10	as	as	ADP
admet-291	167	11	drugdrug	drugdrug	NOUN
admet-291	167	12	interactions	interaction	NOUN
admet-291	167	13	.	.	PUNCT
admet-291	168	1	we	we	PRON
admet-291	168	2	have	have	AUX
admet-291	168	3	predicted	predict	VERB
admet-291	168	4	the	the	DET
admet-291	168	5	total	total	ADJ
admet-291	168	6	clearance	clearance	NOUN
admet-291	168	7	for	for	ADP
admet-291	168	8	drugs	drug	NOUN
admet-291	168	9	and	and	CCONJ
admet-291	168	10	lead	lead	ADJ
admet-291	168	11	candidates	candidate	NOUN
admet-291	168	12	measured	measure	VERB
admet-291	168	13	by	by	ADP
admet-291	168	14	the	the	DET
admet-291	168	15	admet	admet	PROPN
admet-291	168	16	&	&	CCONJ
admet-291	168	17	dmpk	dmpk	PROPN
admet-291	168	18	4(2	4(2	NUM
admet-291	168	19	)	)	PUNCT
admet-291	168	20	(	(	PUNCT
admet-291	168	21	2016	2016	NUM
admet-291	168	22	)	)	PUNCT
admet-291	168	23	98	98	NUM
admet-291	168	24	-	-	SYM
admet-291	168	25	113	113	NUM
admet-291	168	26	defining	define	VERB
admet-291	168	27	natural	natural	ADJ
admet-291	168	28	product	product	NOUN
admet-291	168	29	derived	derive	VERB
admet-291	168	30	anticancer	anticancer	NOUN
admet-291	168	31	drug	drug	NOUN
admet-291	168	32	space	space	NOUN
admet-291	168	33	doi	doi	NOUN
admet-291	168	34	:	:	PUNCT
admet-291	168	35	10.5599	10.5599	NUM
admet-291	168	36	/	/	SYM
admet-291	168	37	admet.4.2.291	admet.4.2.291	PRON
admet-291	168	38	109	109	NUM
admet-291	168	39	proportionality	proportionality	NOUN
admet-291	168	40	constant	constant	ADJ
admet-291	168	41	and	and	CCONJ
admet-291	168	42	primarily	primarily	ADV
admet-291	168	43	occur	occur	VERB
admet-291	168	44	as	as	ADP
admet-291	168	45	a	a	DET
admet-291	168	46	combination	combination	NOUN
admet-291	168	47	of	of	ADP
admet-291	168	48	hepatic	hepatic	ADJ
admet-291	168	49	and	and	CCONJ
admet-291	168	50	renal	renal	ADJ
admet-291	168	51	clearance	clearance	NOUN
admet-291	168	52	mentioned	mention	VERB
admet-291	168	53	in	in	ADP
admet-291	168	54	table	table	NOUN
admet-291	168	55	3	3	NUM
admet-291	168	56	.	.	PUNCT
admet-291	169	1	hughes	hughe	NOUN
admet-291	169	2	et	et	PROPN
admet-291	169	3	al	al	PROPN
admet-291	169	4	.	.	PROPN
admet-291	169	5	have	have	AUX
admet-291	169	6	done	do	VERB
admet-291	169	7	the	the	DET
admet-291	169	8	most	most	ADV
admet-291	169	9	considerable	considerable	ADJ
admet-291	169	10	work	work	NOUN
admet-291	169	11	with	with	ADP
admet-291	169	12	regard	regard	NOUN
admet-291	169	13	to	to	ADP
admet-291	169	14	the	the	DET
admet-291	169	15	impact	impact	NOUN
admet-291	169	16	of	of	ADP
admet-291	169	17	molecular	molecular	ADJ
admet-291	169	18	properties	property	NOUN
admet-291	169	19	on	on	ADP
admet-291	169	20	in	in	ADP
admet-291	169	21	vivo	vivo	ADJ
admet-291	169	22	toxicity	toxicity	NOUN
admet-291	169	23	,	,	PUNCT
admet-291	169	24	led	lead	VERB
admet-291	169	25	to	to	ADP
admet-291	169	26	the	the	DET
admet-291	169	27	“	"	PUNCT
admet-291	169	28	3/75	3/75	NUM
admet-291	169	29	rule	rule	NOUN
admet-291	169	30	”	"	PUNCT
admet-291	169	31	,	,	PUNCT
admet-291	169	32	derived	derive	VERB
admet-291	169	33	from	from	ADP
admet-291	169	34	an	an	DET
admet-291	169	35	analysis	analysis	NOUN
admet-291	169	36	of	of	ADP
admet-291	169	37	exploratory	exploratory	ADJ
admet-291	169	38	or	or	CCONJ
admet-291	169	39	dose	dose	NOUN
admet-291	169	40	-	-	PUNCT
admet-291	169	41	finding	finding	NOUN
admet-291	169	42	toxicology	toxicology	NOUN
admet-291	169	43	studies	study	NOUN
admet-291	169	44	of	of	ADP
admet-291	169	45	245	245	NUM
admet-291	169	46	compounds	compound	NOUN
admet-291	169	47	at	at	ADP
admet-291	169	48	pfizer	pfizer	NOUN
admet-291	169	49	[	[	X
admet-291	169	50	31	31	NUM
admet-291	169	51	]	]	PUNCT
admet-291	169	52	.	.	PUNCT
admet-291	170	1	key	key	ADJ
admet-291	170	2	finding	finding	NOUN
admet-291	170	3	emerged	emerge	VERB
admet-291	170	4	from	from	ADP
admet-291	170	5	this	this	DET
admet-291	170	6	analysis	analysis	NOUN
admet-291	170	7	was	be	AUX
admet-291	170	8	that	that	SCONJ
admet-291	170	9	compounds	compound	VERB
admet-291	170	10	with	with	ADP
admet-291	170	11	a	a	DET
admet-291	170	12	clog	clog	NOUN
admet-291	170	13	p	p	X
admet-291	170	14	<	<	X
admet-291	170	15	3	3	NUM
admet-291	170	16	and	and	CCONJ
admet-291	170	17	tpsa	tpsa	NOUN
admet-291	170	18	>	>	X
admet-291	170	19	75	75	NUM
admet-291	170	20	å	å	PROPN
admet-291	170	21	2	2	NUM
admet-291	170	22	were	be	AUX
admet-291	170	23	2.5	2.5	NUM
admet-291	170	24	times	time	NOUN
admet-291	170	25	more	more	ADV
admet-291	170	26	likely	likely	ADJ
admet-291	170	27	to	to	PART
admet-291	170	28	be	be	AUX
admet-291	170	29	non	non	ADJ
admet-291	170	30	-	-	ADJ
admet-291	170	31	toxic	toxic	ADJ
admet-291	170	32	at	at	ADP
admet-291	170	33	the	the	DET
admet-291	170	34	same	same	ADJ
admet-291	170	35	total	total	ADJ
admet-291	170	36	exposure	exposure	NOUN
admet-291	170	37	.	.	PUNCT
admet-291	171	1	reversely	reversely	ADV
admet-291	171	2	,	,	PUNCT
admet-291	171	3	compounds	compound	VERB
admet-291	171	4	those	those	PRON
admet-291	171	5	with	with	ADP
admet-291	171	6	high	high	ADJ
admet-291	171	7	lipophilicity	lipophilicity	NOUN
admet-291	171	8	(	(	PUNCT
admet-291	171	9	clog	clog	VERB
admet-291	171	10	p	p	PROPN
admet-291	171	11	>	>	X
admet-291	171	12	3	3	NUM
admet-291	171	13	)	)	PUNCT
admet-291	171	14	and	and	CCONJ
admet-291	171	15	low	low	ADJ
admet-291	171	16	polar	polar	ADJ
admet-291	171	17	surface	surface	NOUN
admet-291	171	18	area	area	NOUN
admet-291	171	19	(	(	PUNCT
admet-291	171	20	tpsa	tpsa	NOUN
admet-291	171	21	<	<	X
admet-291	171	22	75	75	NUM
admet-291	171	23	å	å	PROPN
admet-291	171	24	2	2	NUM
admet-291	171	25	)	)	PUNCT
admet-291	171	26	had	have	VERB
admet-291	171	27	an	an	DET
admet-291	171	28	increased	increase	VERB
admet-291	171	29	risk	risk	NOUN
admet-291	171	30	of	of	ADP
admet-291	171	31	widespread	widespread	ADJ
admet-291	171	32	toxicities	toxicity	NOUN
admet-291	171	33	in	in	ADP
admet-291	171	34	short	short	ADJ
admet-291	171	35	-	-	PUNCT
admet-291	171	36	term	term	NOUN
admet-291	171	37	animal	animal	NOUN
admet-291	171	38	studies	study	NOUN
admet-291	171	39	.	.	PUNCT
admet-291	172	1	one	one	NUM
admet-291	172	2	crucial	crucial	ADJ
admet-291	172	3	elucidation	elucidation	NOUN
admet-291	172	4	of	of	ADP
admet-291	172	5	these	these	DET
admet-291	172	6	results	result	NOUN
admet-291	172	7	would	would	AUX
admet-291	172	8	be	be	AUX
admet-291	172	9	that	that	SCONJ
admet-291	172	10	promising	promise	VERB
admet-291	172	11	lipophilic	lipophilic	ADJ
admet-291	172	12	compounds	compound	NOUN
admet-291	172	13	with	with	ADP
admet-291	172	14	small	small	ADJ
admet-291	172	15	polar	polar	ADJ
admet-291	172	16	functionality	functionality	NOUN
admet-291	172	17	likely	likely	ADJ
admet-291	172	18	to	to	PART
admet-291	172	19	have	have	VERB
admet-291	172	20	an	an	DET
admet-291	172	21	increased	increase	VERB
admet-291	172	22	chance	chance	NOUN
admet-291	172	23	of	of	ADP
admet-291	172	24	toxicity	toxicity	NOUN
admet-291	172	25	.	.	PUNCT
admet-291	173	1	a	a	DET
admet-291	173	2	similar	similar	ADJ
admet-291	173	3	study	study	NOUN
admet-291	173	4	by	by	ADP
admet-291	173	5	astrazeneca	astrazeneca	PROPN
admet-291	173	6	[	[	X
admet-291	173	7	32	32	NUM
admet-291	173	8	]	]	PUNCT
admet-291	173	9	on	on	ADP
admet-291	173	10	their	their	PRON
admet-291	173	11	compound	compound	NOUN
admet-291	173	12	failures	failure	NOUN
admet-291	173	13	showed	show	VERB
admet-291	173	14	a	a	DET
admet-291	173	15	different	different	ADJ
admet-291	173	16	profile	profile	NOUN
admet-291	173	17	,	,	PUNCT
admet-291	173	18	with	with	ADP
admet-291	173	19	the	the	DET
admet-291	173	20	majority	majority	NOUN
admet-291	173	21	of	of	ADP
admet-291	173	22	failure	failure	NOUN
admet-291	173	23	happening	happen	VERB
admet-291	173	24	with	with	ADP
admet-291	173	25	tpsa	tpsa	NOUN
admet-291	173	26	>	>	X
admet-291	173	27	75	75	NUM
admet-291	173	28	å2	å2	NOUN
admet-291	173	29	and	and	CCONJ
admet-291	173	30	clog	clog	VERB
admet-291	173	31	p	p	PRON
admet-291	173	32	<	<	X
admet-291	173	33	3	3	NUM
admet-291	173	34	.	.	PUNCT
admet-291	173	35	though	though	ADV
admet-291	173	36	,	,	PUNCT
admet-291	173	37	attrition	attrition	NOUN
admet-291	173	38	in	in	ADP
admet-291	173	39	the	the	DET
admet-291	173	40	high	high	ADJ
admet-291	173	41	-	-	PUNCT
admet-291	173	42	log	log	NOUN
admet-291	173	43	p	p	NOUN
admet-291	173	44	–	–	PUNCT
admet-291	173	45	low	low	ADJ
admet-291	173	46	-	-	PUNCT
admet-291	173	47	tpsa	tpsa	NOUN
admet-291	173	48	space	space	NOUN
admet-291	173	49	can	can	AUX
admet-291	173	50	readily	readily	ADV
admet-291	173	51	be	be	AUX
admet-291	173	52	rationalized	rationalize	VERB
admet-291	173	53	via	via	ADP
admet-291	173	54	consideration	consideration	NOUN
admet-291	173	55	of	of	ADP
admet-291	173	56	promiscuity	promiscuity	NOUN
admet-291	173	57	and	and	CCONJ
admet-291	173	58	interactions	interaction	NOUN
admet-291	173	59	across	across	ADP
admet-291	173	60	a	a	DET
admet-291	173	61	range	range	NOUN
admet-291	173	62	of	of	ADP
admet-291	173	63	systems	system	NOUN
admet-291	173	64	.	.	PUNCT
admet-291	174	1	further	further	PROPN
admet-291	174	2	eli	eli	PROPN
admet-291	174	3	lilly	lilly	PROPN
admet-291	174	4	company	company	PROPN
admet-291	174	5	study	study	NOUN
admet-291	174	6	of	of	ADP
admet-291	174	7	>	>	X
admet-291	174	8	400	400	NUM
admet-291	174	9	(	(	PUNCT
admet-291	174	10	eli	eli	PROPN
admet-291	174	11	lilly	lilly	PROPN
admet-291	174	12	)	)	PUNCT
admet-291	174	13	compounds	compound	NOUN
admet-291	174	14	supported	support	VERB
admet-291	174	15	the	the	DET
admet-291	174	16	influence	influence	NOUN
admet-291	174	17	of	of	ADP
admet-291	174	18	compound	compound	ADJ
admet-291	174	19	lipophilicity	lipophilicity	NOUN
admet-291	174	20	on	on	ADP
admet-291	174	21	toxicology	toxicology	NOUN
admet-291	174	22	in	in	ADP
admet-291	174	23	rat	rat	NOUN
admet-291	174	24	toxicological	toxicological	ADJ
admet-291	174	25	studies	study	NOUN
admet-291	174	26	[	[	X
admet-291	174	27	33	33	NUM
admet-291	174	28	]	]	PUNCT
admet-291	174	29	.	.	PUNCT
admet-291	175	1	in	in	ADP
admet-291	175	2	this	this	DET
admet-291	175	3	analysis	analysis	NOUN
admet-291	175	4	,	,	PUNCT
admet-291	175	5	there	there	PRON
admet-291	175	6	was	be	VERB
admet-291	175	7	a	a	DET
admet-291	175	8	three	three	NUM
admet-291	175	9	-	-	ADJ
admet-291	175	10	fold	fold	ADJ
admet-291	175	11	enrichment	enrichment	NOUN
admet-291	175	12	in	in	ADP
admet-291	175	13	toxic	toxic	ADJ
admet-291	175	14	compounds	compound	NOUN
admet-291	175	15	when	when	SCONJ
admet-291	175	16	log	log	VERB
admet-291	175	17	p	p	PROPN
admet-291	175	18	>	>	X
admet-291	175	19	3	3	NUM
admet-291	175	20	,	,	PUNCT
admet-291	175	21	but	but	CCONJ
admet-291	175	22	tpsa	tpsa	NOUN
admet-291	175	23	had	have	VERB
admet-291	175	24	little	little	ADJ
admet-291	175	25	or	or	CCONJ
admet-291	175	26	no	no	PRON
admet-291	175	27	influence	influence	NOUN
admet-291	175	28	.	.	PUNCT
admet-291	176	1	clearly	clearly	ADV
admet-291	176	2	,	,	PUNCT
admet-291	176	3	the	the	DET
admet-291	176	4	benefits	benefit	NOUN
admet-291	176	5	of	of	ADP
admet-291	176	6	establishing	establish	VERB
admet-291	176	7	a	a	DET
admet-291	176	8	link	link	NOUN
admet-291	176	9	between	between	ADP
admet-291	176	10	important	important	ADJ
admet-291	176	11	clinically	clinically	ADV
admet-291	176	12	relevant	relevant	ADJ
admet-291	176	13	end	end	NOUN
admet-291	176	14	points	point	NOUN
admet-291	176	15	and	and	CCONJ
admet-291	176	16	simple	simple	ADJ
admet-291	176	17	descriptors	descriptor	NOUN
admet-291	176	18	such	such	ADJ
admet-291	176	19	as	as	ADP
admet-291	176	20	log	log	NOUN
admet-291	176	21	p	p	NOUN
admet-291	176	22	and	and	CCONJ
admet-291	176	23	psa	psa	PROPN
admet-291	176	24	(	(	PUNCT
admet-291	176	25	which	which	PRON
admet-291	176	26	can	can	AUX
admet-291	176	27	be	be	AUX
admet-291	176	28	easily	easily	ADV
admet-291	176	29	calculated	calculate	VERB
admet-291	176	30	before	before	ADP
admet-291	176	31	synthesis	synthesis	NOUN
admet-291	176	32	)	)	PUNCT
admet-291	176	33	are	be	AUX
admet-291	176	34	highly	highly	ADV
admet-291	176	35	attractive	attractive	ADJ
admet-291	176	36	.	.	PUNCT
admet-291	177	1	we	we	PRON
admet-291	177	2	also	also	ADV
admet-291	177	3	analyzed	analyze	VERB
admet-291	177	4	our	our	PRON
admet-291	177	5	natural	natural	ADJ
admet-291	177	6	product	product	NOUN
admet-291	177	7	derived	derive	VERB
admet-291	177	8	drugs	drug	NOUN
admet-291	177	9	and	and	CCONJ
admet-291	177	10	lead	lead	NOUN
admet-291	177	11	compounds	compound	NOUN
admet-291	177	12	predicted	predict	VERB
admet-291	177	13	toxicity	toxicity	NOUN
admet-291	177	14	endpoints	endpoint	NOUN
admet-291	177	15	,	,	PUNCT
admet-291	177	16	to	to	PART
admet-291	177	17	establish	establish	VERB
admet-291	177	18	meaningful	meaningful	ADJ
admet-291	177	19	correlations	correlation	NOUN
admet-291	177	20	between	between	ADP
admet-291	177	21	physicochemical	physicochemical	ADJ
admet-291	177	22	properties	property	NOUN
admet-291	177	23	and	and	CCONJ
admet-291	177	24	toxicity	toxicity	NOUN
admet-291	177	25	profile	profile	NOUN
admet-291	177	26	of	of	ADP
admet-291	177	27	compounds	compound	NOUN
admet-291	177	28	.	.	PUNCT
admet-291	178	1	predicted	predict	VERB
admet-291	178	2	toxicities	toxicity	NOUN
admet-291	178	3	of	of	ADP
admet-291	178	4	drugs	drug	NOUN
admet-291	178	5	and	and	CCONJ
admet-291	178	6	leads	lead	NOUN
admet-291	178	7	have	have	AUX
admet-291	178	8	been	be	AUX
admet-291	178	9	categorized	categorize	VERB
admet-291	178	10	as	as	ADP
admet-291	178	11	“	"	PUNCT
admet-291	178	12	yes	yes	INTJ
admet-291	178	13	”	"	PUNCT
admet-291	178	14	or	or	CCONJ
admet-291	178	15	“	"	PUNCT
admet-291	178	16	no	no	INTJ
admet-291	178	17	”	"	PUNCT
admet-291	178	18	.	.	PUNCT
admet-291	179	1	most	most	ADJ
admet-291	179	2	of	of	ADP
admet-291	179	3	anticancer	anticancer	NOUN
admet-291	179	4	drugs	drug	NOUN
admet-291	179	5	in	in	ADP
admet-291	179	6	our	our	PRON
admet-291	179	7	dataset	dataset	NOUN
admet-291	179	8	having	have	VERB
admet-291	179	9	the	the	DET
admet-291	179	10	low	low	ADJ
admet-291	179	11	lipophilicity	lipophilicity	NOUN
admet-291	179	12	(	(	PUNCT
admet-291	179	13	clog	clog	VERB
admet-291	179	14	p	p	X
admet-291	179	15	<	<	X
admet-291	179	16	3.5	3.5	NUM
admet-291	179	17	)	)	PUNCT
admet-291	179	18	are	be	AUX
admet-291	179	19	showing	show	VERB
admet-291	179	20	the	the	DET
admet-291	179	21	hepatotoxicity	hepatotoxicity	NOUN
admet-291	179	22	(	(	PUNCT
admet-291	179	23	e.g.	e.g.	ADV
admet-291	179	24	camptothecin	camptothecin	NOUN
admet-291	179	25	,	,	PUNCT
admet-291	179	26	rohitukine	rohitukine	PROPN
admet-291	179	27	,	,	PUNCT
admet-291	179	28	carfilzomib	carfilzomib	NOUN
admet-291	179	29	,	,	PUNCT
admet-291	179	30	docetaxel	docetaxel	NOUN
admet-291	179	31	,	,	PUNCT
admet-291	179	32	etc	etc	X
admet-291	179	33	.	.	X
admet-291	179	34	)	)	PUNCT
admet-291	179	35	,	,	PUNCT
admet-291	179	36	out	out	ADP
admet-291	179	37	of	of	ADP
admet-291	179	38	which	which	PRON
admet-291	179	39	some	some	DET
admet-291	179	40	drugs	drug	NOUN
admet-291	179	41	also	also	ADV
admet-291	179	42	having	having	AUX
admet-291	179	43	clog	clog	VERB
admet-291	179	44	p	p	PRON
admet-291	179	45	<	<	X
admet-291	179	46	3.5	3.5	NUM
admet-291	179	47	and	and	CCONJ
admet-291	179	48	mw	mw	ADJ
admet-291	179	49	>	>	X
admet-291	179	50	700	700	NUM
admet-291	179	51	also	also	ADV
admet-291	179	52	showing	show	VERB
admet-291	179	53	hepatotoxicity	hepatotoxicity	NOUN
admet-291	179	54	(	(	PUNCT
admet-291	179	55	e.g.	e.g.	ADV
admet-291	179	56	vinblastine	vinblastine	NOUN
admet-291	179	57	,	,	PUNCT
admet-291	179	58	vincristine	vincristine	NOUN
admet-291	179	59	,	,	PUNCT
admet-291	179	60	vindesine	vindesine	PROPN
admet-291	179	61	,	,	PUNCT
admet-291	179	62	carfilzomib	carfilzomib	NOUN
admet-291	179	63	,	,	PUNCT
admet-291	179	64	and	and	CCONJ
admet-291	179	65	docetaxel	docetaxel	PROPN
admet-291	179	66	,	,	PUNCT
admet-291	179	67	etc	etc	X
admet-291	179	68	.	.	X
admet-291	179	69	)	)	PUNCT
admet-291	179	70	.	.	PUNCT
admet-291	180	1	similarly	similarly	ADV
admet-291	180	2	,	,	PUNCT
admet-291	180	3	four	four	NUM
admet-291	180	4	drugs	drug	NOUN
admet-291	180	5	,	,	PUNCT
admet-291	180	6	showed	show	VERB
admet-291	180	7	the	the	DET
admet-291	180	8	ames	ame	NOUN
admet-291	180	9	toxicity	toxicity	NOUN
admet-291	180	10	,	,	PUNCT
admet-291	180	11	also	also	ADV
admet-291	180	12	having	have	VERB
admet-291	180	13	the	the	DET
admet-291	180	14	low	low	ADJ
admet-291	180	15	lipophilicity	lipophilicity	NOUN
admet-291	180	16	(	(	PUNCT
admet-291	180	17	clog	clog	VERB
admet-291	180	18	p	p	X
admet-291	180	19	<	<	X
admet-291	180	20	2	2	NUM
admet-291	180	21	)	)	PUNCT
admet-291	180	22	.	.	PUNCT
admet-291	181	1	this	this	DET
admet-291	181	2	link	link	NOUN
admet-291	181	3	between	between	ADP
admet-291	181	4	the	the	DET
admet-291	181	5	low	low	ADJ
admet-291	181	6	lipophilicity	lipophilicity	NOUN
admet-291	181	7	of	of	ADP
admet-291	181	8	compounds	compound	NOUN
admet-291	181	9	and	and	CCONJ
admet-291	181	10	toxicity	toxicity	NOUN
admet-291	181	11	is	be	AUX
admet-291	181	12	in	in	ADP
admet-291	181	13	line	line	NOUN
admet-291	181	14	with	with	ADP
admet-291	181	15	the	the	DET
admet-291	181	16	results	result	NOUN
admet-291	181	17	of	of	ADP
admet-291	181	18	hughes	hughes	PROPN
admet-291	181	19	et	et	PROPN
admet-291	181	20	al	al	PROPN
admet-291	181	21	.	.	PUNCT
admet-291	182	1	[	[	X
admet-291	182	2	31	31	NUM
admet-291	182	3	]	]	PUNCT
admet-291	182	4	and	and	CCONJ
admet-291	182	5	other	other	ADJ
admet-291	182	6	research	research	NOUN
admet-291	182	7	groups	group	NOUN
admet-291	182	8	.	.	PUNCT
admet-291	183	1	furthermore	furthermore	ADV
admet-291	183	2	,	,	PUNCT
admet-291	183	3	some	some	DET
admet-291	183	4	drugs	drug	NOUN
admet-291	183	5	showing	show	VERB
admet-291	183	6	the	the	DET
admet-291	183	7	toxicity	toxicity	NOUN
admet-291	183	8	but	but	CCONJ
admet-291	183	9	no	no	DET
admet-291	183	10	specific	specific	ADJ
admet-291	183	11	correlations	correlation	NOUN
admet-291	183	12	with	with	ADP
admet-291	183	13	physicochemical	physicochemical	ADJ
admet-291	183	14	properties	property	NOUN
admet-291	183	15	was	be	AUX
admet-291	183	16	found	find	VERB
admet-291	183	17	,	,	PUNCT
admet-291	183	18	possibly	possibly	ADV
admet-291	183	19	the	the	DET
admet-291	183	20	toxicity	toxicity	NOUN
admet-291	183	21	was	be	AUX
admet-291	183	22	a	a	DET
admet-291	183	23	consequence	consequence	NOUN
admet-291	183	24	of	of	ADP
admet-291	183	25	the	the	DET
admet-291	183	26	primary	primary	ADJ
admet-291	183	27	drug	drug	NOUN
admet-291	183	28	target	target	NOUN
admet-291	183	29	mechanism	mechanism	NOUN
admet-291	183	30	or	or	CCONJ
admet-291	183	31	of	of	ADP
admet-291	183	32	a	a	DET
admet-291	183	33	specific	specific	ADJ
admet-291	183	34	off	off	ADP
admet-291	183	35	-	-	PUNCT
admet-291	183	36	target	target	NOUN
admet-291	183	37	pharmacology	pharmacology	NOUN
admet-291	183	38	.	.	PUNCT
admet-291	184	1	examination	examination	NOUN
admet-291	184	2	of	of	ADP
admet-291	184	3	the	the	DET
admet-291	184	4	relationship	relationship	NOUN
admet-291	184	5	between	between	ADP
admet-291	184	6	physicochemical	physicochemical	ADJ
admet-291	184	7	properties	property	NOUN
admet-291	184	8	and	and	CCONJ
admet-291	184	9	other	other	ADJ
admet-291	184	10	predicted	predict	VERB
admet-291	184	11	toxicity	toxicity	NOUN
admet-291	184	12	end	end	NOUN
admet-291	184	13	points	point	NOUN
admet-291	185	1	,	,	PUNCT
admet-291	185	2	we	we	PRON
admet-291	185	3	found	find	VERB
admet-291	185	4	very	very	ADV
admet-291	185	5	good	good	ADJ
admet-291	185	6	correlation	correlation	NOUN
admet-291	185	7	for	for	ADP
admet-291	185	8	the	the	DET
admet-291	185	9	drug	drug	NOUN
admet-291	185	10	molecules	molecule	NOUN
admet-291	185	11	between	between	ADP
admet-291	185	12	the	the	DET
admet-291	185	13	physicochemical	physicochemical	ADJ
admet-291	185	14	properties	property	NOUN
admet-291	185	15	and	and	CCONJ
admet-291	185	16	oral	oral	ADJ
admet-291	185	17	rat	rat	NOUN
admet-291	185	18	chronic	chronic	ADJ
admet-291	185	19	toxicity	toxicity	NOUN
admet-291	185	20	(	(	PUNCT
admet-291	185	21	loael	loael	PROPN
admet-291	185	22	)	)	PUNCT
admet-291	185	23	.	.	PUNCT
admet-291	186	1	the	the	DET
admet-291	186	2	correlation	correlation	NOUN
admet-291	186	3	coefficient	coefficient	NOUN
admet-291	186	4	of	of	ADP
admet-291	186	5	loael	loael	PROPN
admet-291	186	6	with	with	ADP
admet-291	186	7	mw	mw	PROPN
admet-291	186	8	,	,	PUNCT
admet-291	186	9	hba	hba	NOUN
admet-291	186	10	,	,	PUNCT
admet-291	186	11	hbd	hbd	NOUN
admet-291	186	12	,	,	PUNCT
admet-291	186	13	tpsa	tpsa	NOUN
admet-291	186	14	,	,	PUNCT
admet-291	186	15	and	and	CCONJ
admet-291	186	16	nrot	nrot	NOUN
admet-291	186	17	was	be	AUX
admet-291	186	18	0.85	0.85	NUM
admet-291	186	19	,	,	PUNCT
admet-291	186	20	0.84	0.84	NUM
admet-291	186	21	,	,	PUNCT
admet-291	186	22	0.68	0.68	NUM
admet-291	186	23	,	,	PUNCT
admet-291	186	24	0.84	0.84	NUM
admet-291	186	25	,	,	PUNCT
admet-291	186	26	and	and	CCONJ
admet-291	186	27	0.77	0.77	NUM
admet-291	186	28	,	,	PUNCT
admet-291	186	29	respectively	respectively	ADV
admet-291	186	30	.	.	PUNCT
admet-291	187	1	all	all	DET
admet-291	187	2	five	five	NUM
admet-291	187	3	physicochemical	physicochemical	ADJ
admet-291	187	4	properties	property	NOUN
admet-291	187	5	are	be	AUX
admet-291	187	6	positively	positively	ADV
admet-291	187	7	correlated	correlate	VERB
admet-291	187	8	with	with	ADP
admet-291	187	9	the	the	DET
admet-291	187	10	loael	loael	NOUN
admet-291	187	11	,	,	PUNCT
admet-291	187	12	suggesting	suggest	VERB
admet-291	187	13	the	the	DET
admet-291	187	14	need	need	NOUN
admet-291	187	15	for	for	ADP
admet-291	187	16	the	the	DET
admet-291	187	17	optimization	optimization	NOUN
admet-291	187	18	of	of	ADP
admet-291	187	19	these	these	DET
admet-291	187	20	physicochemical	physicochemical	ADJ
admet-291	187	21	parameters	parameter	NOUN
admet-291	187	22	to	to	PART
admet-291	187	23	avoid	avoid	VERB
admet-291	187	24	the	the	DET
admet-291	187	25	loael	loael	ADJ
admet-291	187	26	toxicity	toxicity	NOUN
admet-291	187	27	.	.	PUNCT
admet-291	188	1	on	on	ADP
admet-291	188	2	the	the	DET
admet-291	188	3	other	other	ADJ
admet-291	188	4	hand	hand	NOUN
admet-291	188	5	,	,	PUNCT
admet-291	188	6	no	no	DET
admet-291	188	7	correlation	correlation	NOUN
admet-291	188	8	was	be	AUX
admet-291	188	9	observed	observe	VERB
admet-291	188	10	between	between	ADP
admet-291	188	11	the	the	DET
admet-291	188	12	loael	loael	ADJ
admet-291	188	13	and	and	CCONJ
admet-291	188	14	physicochemical	physicochemical	ADJ
admet-291	188	15	properties	property	NOUN
admet-291	188	16	for	for	ADP
admet-291	188	17	lead	lead	ADJ
admet-291	188	18	molecules	molecule	NOUN
admet-291	188	19	,	,	PUNCT
admet-291	188	20	which	which	PRON
admet-291	188	21	is	be	AUX
admet-291	188	22	evident	evident	ADJ
admet-291	188	23	from	from	ADP
admet-291	188	24	the	the	DET
admet-291	188	25	table	table	NOUN
admet-291	188	26	3	3	NUM
admet-291	188	27	,	,	PUNCT
admet-291	188	28	that	that	SCONJ
admet-291	188	29	drug	drug	NOUN
admet-291	188	30	molecules	molecule	NOUN
admet-291	188	31	showed	show	VERB
admet-291	188	32	more	more	ADJ
admet-291	188	33	toxicity	toxicity	NOUN
admet-291	188	34	endpoints	endpoint	NOUN
admet-291	188	35	compare	compare	VERB
admet-291	188	36	to	to	PART
admet-291	188	37	lead	lead	VERB
admet-291	188	38	molecules	molecule	NOUN
admet-291	188	39	.	.	PUNCT
admet-291	189	1	hence	hence	ADV
admet-291	189	2	,	,	PUNCT
admet-291	189	3	establishing	establish	VERB
admet-291	189	4	meaningful	meaningful	ADJ
admet-291	189	5	correlations	correlation	NOUN
admet-291	189	6	between	between	ADP
admet-291	189	7	the	the	DET
admet-291	189	8	physicochemical	physicochemical	ADJ
admet-291	189	9	properties	property	NOUN
admet-291	189	10	and	and	CCONJ
admet-291	189	11	toxicity	toxicity	NOUN
admet-291	189	12	of	of	ADP
admet-291	189	13	natural	natural	ADJ
admet-291	189	14	product	product	NOUN
admet-291	189	15	derived	derive	VERB
admet-291	189	16	oral	oral	ADJ
admet-291	189	17	anticancer	anticancer	NOUN
admet-291	189	18	drugs	drug	NOUN
admet-291	189	19	and	and	CCONJ
admet-291	189	20	leads	lead	NOUN
admet-291	189	21	might	might	AUX
admet-291	189	22	be	be	AUX
admet-291	189	23	useful	useful	ADJ
admet-291	189	24	for	for	ADP
admet-291	189	25	future	future	ADJ
admet-291	189	26	anticancer	anticancer	NOUN
admet-291	189	27	drug	drug	NOUN
admet-291	189	28	discovery	discovery	NOUN
admet-291	189	29	.	.	PUNCT
admet-291	190	1	admet	admet	PROPN
admet-291	190	2	&	&	CCONJ
admet-291	190	3	dmpk	dmpk	PROPN
admet-291	190	4	4(2	4(2	NUM
admet-291	190	5	)	)	PUNCT
admet-291	190	6	(	(	PUNCT
admet-291	190	7	2016	2016	NUM
admet-291	190	8	)	)	PUNCT
admet-291	190	9	98	98	NUM
admet-291	190	10	-	-	SYM
admet-291	190	11	113	113	NUM
admet-291	190	12	defining	define	VERB
admet-291	190	13	natural	natural	ADJ
admet-291	190	14	product	product	NOUN
admet-291	190	15	derived	derive	VERB
admet-291	190	16	anticancer	anticancer	NOUN
admet-291	190	17	drug	drug	NOUN
admet-291	190	18	space	space	NOUN
admet-291	190	19	doi	doi	NOUN
admet-291	190	20	:	:	PUNCT
admet-291	190	21	10.5599	10.5599	NUM
admet-291	190	22	/	/	SYM
admet-291	190	23	admet.4.2.291	admet.4.2.291	DET
admet-291	190	24	110	110	NUM
admet-291	190	25	table	table	NOUN
admet-291	190	26	3	3	NUM
admet-291	190	27	.	.	PUNCT
admet-291	191	1	computed	compute	VERB
admet-291	191	2	safety	safety	NOUN
admet-291	191	3	end	end	NOUN
admet-291	191	4	points	point	NOUN
admet-291	191	5	for	for	ADP
admet-291	191	6	anticancer	anticancer	NOUN
admet-291	191	7	lead	lead	NOUN
admet-291	191	8	candidates	candidate	NOUN
admet-291	191	9	and	and	CCONJ
admet-291	191	10	drugs	drug	NOUN
admet-291	191	11	1	1	NUM
admet-291	191	12	cyp2d6	cyp2d6	NOUN
admet-291	191	13	inhibitor	inhibitor	NOUN
admet-291	191	14	cyp3a4	cyp3a4	PROPN
admet-291	191	15	inhibitor	inhibitor	PROPN
admet-291	191	16	total	total	NOUN
admet-291	191	17	clearance	clearance	NOUN
admet-291	191	18	renal	renal	ADJ
admet-291	191	19	oct2	oct2	NOUN
admet-291	191	20	substrate	substrate	NOUN
admet-291	191	21	ames	ame	NOUN
admet-291	191	22	toxicity	toxicity	NOUN
admet-291	191	23	herg	herg	PROPN
admet-291	191	24	inhibitor	inhibitor	NOUN
admet-291	191	25	oral	oral	ADJ
admet-291	191	26	rat	rat	NOUN
admet-291	191	27	acute	acute	NOUN
admet-291	191	28	toxicity	toxicity	NOUN
admet-291	191	29	(	(	PUNCT
admet-291	191	30	ld50	ld50	PROPN
admet-291	191	31	)	)	PUNCT
admet-291	191	32	oral	oral	ADJ
admet-291	191	33	rat	rat	NOUN
admet-291	191	34	chronic	chronic	ADJ
admet-291	191	35	toxicity	toxicity	NOUN
admet-291	191	36	(	(	PUNCT
admet-291	191	37	loael	loael	ADJ
admet-291	191	38	)	)	PUNCT
admet-291	191	39	hepatotoxicity	hepatotoxicity	NOUN
admet-291	191	40	skin	skin	NOUN
admet-291	191	41	sensitisation	sensitisation	NOUN
admet-291	191	42	13	13	NUM
admet-291	191	43	-	-	PUNCT
admet-291	191	44	epi	epi	NOUN
admet-291	191	45	-	-	NOUN
admet-291	191	46	sclareol	sclareol	NOUN
admet-291	192	1	no	no	INTJ
admet-291	192	2	no	no	DET
admet-291	192	3	0.183	0.183	NUM
admet-291	192	4	no	no	INTJ
admet-291	192	5	no	no	INTJ
admet-291	192	6	no	no	DET
admet-291	192	7	1.526	1.526	NUM
admet-291	192	8	2.231	2.231	NUM
admet-291	192	9	no	no	DET
admet-291	192	10	no	no	DET
admet-291	192	11	6	6	NUM
admet-291	192	12	-	-	PUNCT
admet-291	192	13	gingerol	gingerol	NOUN
admet-291	192	14	no	no	INTJ
admet-291	192	15	no	no	DET
admet-291	192	16	1.369	1.369	NUM
admet-291	193	1	no	no	INTJ
admet-291	193	2	no	no	INTJ
admet-291	193	3	no	no	PRON
admet-291	193	4	1.861	1.861	NUM
admet-291	193	5	2.381	2.381	NUM
admet-291	194	1	no	no	INTJ
admet-291	194	2	no	no	INTJ
admet-291	194	3	ahwagandhanolide	ahwagandhanolide	ADV
admet-291	195	1	no	no	INTJ
admet-291	195	2	yes	yes	INTJ
admet-291	195	3	-0.711	-0.711	PUNCT
admet-291	196	1	no	no	INTJ
admet-291	196	2	no	no	INTJ
admet-291	196	3	no	no	DET
admet-291	196	4	2.011	2.011	NUM
admet-291	196	5	3.113	3.113	NUM
admet-291	196	6	yes	yes	INTJ
admet-291	197	1	no	no	DET
admet-291	197	2	allicin	allicin	NOUN
admet-291	197	3	no	no	INTJ
admet-291	197	4	no	no	INTJ
admet-291	197	5	0.721	0.721	NUM
admet-291	198	1	no	no	INTJ
admet-291	198	2	no	no	INTJ
admet-291	198	3	no	no	DET
admet-291	198	4	2.423	2.423	NUM
admet-291	198	5	1.317	1.317	NUM
admet-291	198	6	no	no	PRON
admet-291	199	1	yes	yes	INTJ
admet-291	199	2	anethol	anethol	NOUN
admet-291	199	3	no	no	DET
admet-291	199	4	no	no	DET
admet-291	199	5	0.279	0.279	NUM
admet-291	200	1	no	no	INTJ
admet-291	200	2	no	no	INTJ
admet-291	200	3	no	no	DET
admet-291	200	4	2.03	2.03	NUM
admet-291	200	5	2.204	2.204	NUM
admet-291	200	6	no	no	PRON
admet-291	200	7	yes	yes	INTJ
admet-291	200	8	berberine	berberine	NOUN
admet-291	201	1	no	no	DET
admet-291	201	2	no	no	DET
admet-291	201	3	1.324	1.324	NUM
admet-291	201	4	no	no	INTJ
admet-291	201	5	no	no	INTJ
admet-291	201	6	no	no	PRON
admet-291	201	7	2.587	2.587	NUM
admet-291	201	8	1.998	1.998	NUM
admet-291	201	9	no	no	INTJ
admet-291	201	10	no	no	DET
admet-291	201	11	beta	beta	ADJ
admet-291	201	12	carotene	carotene	NOUN
admet-291	201	13	no	no	DET
admet-291	201	14	no	no	DET
admet-291	201	15	1.024	1.024	NUM
admet-291	202	1	no	no	INTJ
admet-291	202	2	no	no	INTJ
admet-291	202	3	no	no	DET
admet-291	202	4	1.766	1.766	NUM
admet-291	202	5	0.666	0.666	NUM
admet-291	202	6	no	no	PRON
admet-291	202	7	no	no	DET
admet-291	202	8	betulinic	betulinic	ADJ
admet-291	202	9	acid	acid	NOUN
admet-291	203	1	no	no	INTJ
admet-291	203	2	no	no	DET
admet-291	203	3	0.076	0.076	NUM
admet-291	204	1	no	no	INTJ
admet-291	205	1	no	no	INTJ
admet-291	205	2	no	no	DET
admet-291	205	3	2.298	2.298	NUM
admet-291	205	4	2.161	2.161	NUM
admet-291	205	5	no	no	PRON
admet-291	205	6	no	no	DET
admet-291	205	7	capsaicin	capsaicin	NOUN
admet-291	206	1	no	no	INTJ
admet-291	206	2	no	no	DET
admet-291	206	3	1.269	1.269	NUM
admet-291	206	4	no	no	INTJ
admet-291	206	5	no	no	INTJ
admet-291	206	6	no	no	DET
admet-291	206	7	1.998	1.998	NUM
admet-291	206	8	2.373	2.373	NUM
admet-291	206	9	yes	yes	INTJ
admet-291	207	1	no	no	DET
admet-291	207	2	catechins	catechin	NOUN
admet-291	207	3	no	no	INTJ
admet-291	207	4	no	no	DET
admet-291	207	5	0.215	0.215	NUM
admet-291	208	1	no	no	INTJ
admet-291	208	2	yes	yes	INTJ
admet-291	209	1	no	no	DET
admet-291	209	2	2.101	2.101	NUM
admet-291	209	3	2.076	2.076	NUM
admet-291	209	4	no	no	DET
admet-291	209	5	no	no	DET
admet-291	209	6	corchorusin	corchorusin	NOUN
admet-291	209	7	-	-	PUNCT
admet-291	209	8	d	d	NOUN
admet-291	209	9	no	no	INTJ
admet-291	209	10	no	no	INTJ
admet-291	209	11	-0.069	-0.069	INTJ
admet-291	209	12	no	no	INTJ
admet-291	209	13	no	no	INTJ
admet-291	209	14	no	no	DET
admet-291	209	15	2.094	2.094	NUM
admet-291	209	16	2.341	2.341	NUM
admet-291	209	17	no	no	DET
admet-291	209	18	no	no	DET
admet-291	209	19	curcumin	curcumin	NOUN
admet-291	210	1	no	no	INTJ
admet-291	211	1	yes	yes	INTJ
admet-291	211	2	0.014	0.014	NUM
admet-291	212	1	no	no	INTJ
admet-291	212	2	no	no	INTJ
admet-291	213	1	no	no	PRON
admet-291	213	2	1.93	1.93	NUM
admet-291	213	3	2.421	2.421	NUM
admet-291	213	4	no	no	INTJ
admet-291	213	5	no	no	DET
admet-291	213	6	diallyl	diallyl	NOUN
admet-291	213	7	sulfide	sulfide	NOUN
admet-291	213	8	no	no	DET
admet-291	213	9	no	no	DET
admet-291	213	10	0.562	0.562	NUM
admet-291	213	11	no	no	INTJ
admet-291	213	12	no	no	INTJ
admet-291	213	13	no	no	DET
admet-291	213	14	2.274	2.274	NUM
admet-291	213	15	1.689	1.689	NUM
admet-291	213	16	no	no	INTJ
admet-291	214	1	yes	yes	INTJ
admet-291	214	2	diosgenin	diosgenin	VERB
admet-291	215	1	no	no	INTJ
admet-291	215	2	no	no	INTJ
admet-291	215	3	0.287	0.287	NUM
admet-291	216	1	no	no	INTJ
admet-291	216	2	no	no	INTJ
admet-291	216	3	no	no	DET
admet-291	216	4	2.408	2.408	NUM
admet-291	216	5	1.496	1.496	NUM
admet-291	216	6	no	no	INTJ
admet-291	216	7	no	no	DET
admet-291	216	8	ellagic	ellagic	ADJ
admet-291	216	9	acid	acid	NOUN
admet-291	217	1	no	no	INTJ
admet-291	217	2	no	no	DET
admet-291	217	3	0.539	0.539	NUM
admet-291	218	1	no	no	INTJ
admet-291	218	2	yes	yes	INTJ
admet-291	219	1	no	no	DET
admet-291	219	2	2.201	2.201	NUM
admet-291	219	3	1.947	1.947	NUM
admet-291	219	4	no	no	INTJ
admet-291	220	1	no	no	INTJ
admet-291	220	2	eugenol	eugenol	NOUN
admet-291	220	3	no	no	INTJ
admet-291	221	1	no	no	DET
admet-291	221	2	0.28	0.28	NUM
admet-291	221	3	no	no	INTJ
admet-291	222	1	no	no	INTJ
admet-291	222	2	no	no	DET
admet-291	222	3	1.994	1.994	NUM
admet-291	222	4	2.304	2.304	NUM
admet-291	223	1	no	no	INTJ
admet-291	224	1	yes	yes	INTJ
admet-291	224	2	genistein	genistein	INTJ
admet-291	225	1	no	no	INTJ
admet-291	225	2	no	no	DET
admet-291	225	3	0.241	0.241	NUM
admet-291	226	1	no	no	INTJ
admet-291	226	2	yes	yes	INTJ
admet-291	227	1	no	no	DET
admet-291	227	2	2.309	2.309	NUM
admet-291	227	3	2.075	2.075	NUM
admet-291	227	4	no	no	PRON
admet-291	227	5	no	no	DET
admet-291	227	6	indole-3	indole-3	NOUN
admet-291	227	7	-	-	PUNCT
admet-291	227	8	carbinol	carbinol	NOUN
admet-291	227	9	no	no	INTJ
admet-291	227	10	no	no	DET
admet-291	227	11	0.555	0.555	NUM
admet-291	227	12	no	no	INTJ
admet-291	227	13	no	no	INTJ
admet-291	227	14	no	no	DET
admet-291	227	15	2.301	2.301	NUM
admet-291	227	16	1.836	1.836	NUM
admet-291	227	17	no	no	INTJ
admet-291	227	18	yes	yes	INTJ
admet-291	227	19	limonen	limonen	INTJ
admet-291	228	1	no	no	INTJ
admet-291	228	2	no	no	DET
admet-291	228	3	0.224	0.224	NUM
admet-291	229	1	no	no	INTJ
admet-291	230	1	no	no	INTJ
admet-291	230	2	no	no	DET
admet-291	230	3	2.257	2.257	NUM
admet-291	230	4	2.204	2.204	NUM
admet-291	230	5	no	no	INTJ
admet-291	231	1	yes	yes	INTJ
admet-291	231	2	longimide	longimide	INTJ
admet-291	232	1	no	no	INTJ
admet-291	232	2	no	no	DET
admet-291	232	3	0.036	0.036	NUM
admet-291	233	1	no	no	INTJ
admet-291	233	2	no	no	INTJ
admet-291	234	1	no	no	DET
admet-291	234	2	2.347	2.347	NUM
admet-291	234	3	1.445	1.445	NUM
admet-291	234	4	yes	yes	INTJ
admet-291	235	1	no	no	DET
admet-291	235	2	longitriol	longitriol	NOUN
admet-291	235	3	no	no	INTJ
admet-291	235	4	no	no	DET
admet-291	235	5	0.239	0.239	NUM
admet-291	236	1	no	no	INTJ
admet-291	236	2	no	no	INTJ
admet-291	236	3	no	no	PRON
admet-291	236	4	2.218	2.218	NUM
admet-291	236	5	2.035	2.035	NUM
admet-291	236	6	no	no	INTJ
admet-291	236	7	no	no	DET
admet-291	236	8	lycopene	lycopene	NOUN
admet-291	236	9	no	no	DET
admet-291	236	10	no	no	DET
admet-291	236	11	1.912	1.912	NUM
admet-291	237	1	no	no	INTJ
admet-291	237	2	no	no	INTJ
admet-291	237	3	no	no	DET
admet-291	237	4	1.461	1.461	NUM
admet-291	237	5	0.764	0.764	NUM
admet-291	237	6	no	no	DET
admet-291	237	7	no	no	DET
admet-291	237	8	methyl	methyl	NOUN
admet-291	237	9	anolensate	anolensate	ADJ
admet-291	237	10	no	no	INTJ
admet-291	237	11	yes	yes	INTJ
admet-291	237	12	0.265	0.265	NUM
admet-291	238	1	no	no	INTJ
admet-291	239	1	no	no	INTJ
admet-291	240	1	no	no	DET
admet-291	240	2	2.594	2.594	NUM
admet-291	240	3	1.088	1.088	NUM
admet-291	240	4	no	no	DET
admet-291	240	5	no	no	DET
admet-291	240	6	resveratrol	resveratrol	NOUN
admet-291	240	7	no	no	PRON
admet-291	240	8	no	no	DET
admet-291	240	9	0.147	0.147	NUM
admet-291	241	1	no	no	INTJ
admet-291	241	2	yes	yes	INTJ
admet-291	242	1	no	no	DET
admet-291	242	2	2.072	2.072	NUM
admet-291	242	3	2.605	2.605	NUM
admet-291	242	4	no	no	PRON
admet-291	242	5	no	no	DET
admet-291	242	6	s	s	NOUN
admet-291	242	7	-	-	PUNCT
admet-291	242	8	allyl	allyl	ADJ
admet-291	242	9	cyteine	cyteine	NOUN
admet-291	242	10	no	no	INTJ
admet-291	242	11	no	no	DET
admet-291	242	12	0.613	0.613	NUM
admet-291	243	1	no	no	INTJ
admet-291	243	2	no	no	INTJ
admet-291	243	3	no	no	PRON
admet-291	243	4	2.153	2.153	NUM
admet-291	243	5	2.479	2.479	NUM
admet-291	243	6	no	no	DET
admet-291	243	7	no	no	DET
admet-291	243	8	silymarin	silymarin	NOUN
admet-291	244	1	no	no	INTJ
admet-291	244	2	no	no	INTJ
admet-291	244	3	-0.092	-0.092	PUNCT
admet-291	245	1	no	no	INTJ
admet-291	245	2	no	no	INTJ
admet-291	245	3	no	no	DET
admet-291	245	4	2.184	2.184	NUM
admet-291	245	5	2.593	2.593	NUM
admet-291	245	6	no	no	DET
admet-291	245	7	no	no	DET
admet-291	245	8	withaferin	withaferin	NOUN
admet-291	245	9	a	a	PRON
admet-291	245	10	no	no	INTJ
admet-291	245	11	no	no	INTJ
admet-291	245	12	0.37	0.37	NUM
admet-291	246	1	no	no	INTJ
admet-291	246	2	no	no	INTJ
admet-291	246	3	no	no	DET
admet-291	246	4	2.294	2.294	NUM
admet-291	246	5	1.983	1.983	NUM
admet-291	246	6	no	no	PRON
admet-291	246	7	no	no	DET
admet-291	246	8	deepika	deepika	PROPN
admet-291	246	9	singh	singh	PROPN
admet-291	246	10	admet	admet	PROPN
admet-291	246	11	&	&	CCONJ
admet-291	246	12	dmpk	dmpk	PROPN
admet-291	246	13	4(2	4(2	NUM
admet-291	246	14	)	)	PUNCT
admet-291	246	15	(	(	PUNCT
admet-291	246	16	2016	2016	NUM
admet-291	246	17	)	)	PUNCT
admet-291	246	18	98	98	NUM
admet-291	246	19	-	-	SYM
admet-291	246	20	113	113	NUM
admet-291	246	21	doi	doi	NOUN
admet-291	246	22	:	:	PUNCT
admet-291	246	23	10.5599	10.5599	NUM
admet-291	246	24	/	/	SYM
admet-291	246	25	admet.4.2.291	admet.4.2.291	DET
admet-291	246	26	111	111	NUM
admet-291	246	27	table	table	NOUN
admet-291	246	28	3	3	NUM
admet-291	246	29	.	.	NUM
admet-291	246	30	conituned	conitune	VERB
admet-291	246	31	2	2	NUM
admet-291	246	32	drugs	drug	NOUN
admet-291	246	33	camptothecin	camptothecin	VERB
admet-291	246	34	no	no	DET
admet-291	246	35	no	no	INTJ
admet-291	246	36	0.564	0.564	NUM
admet-291	247	1	no	no	INTJ
admet-291	247	2	yes	yes	INTJ
admet-291	248	1	no	no	DET
admet-291	248	2	2.465	2.465	NUM
admet-291	248	3	1.845	1.845	NUM
admet-291	248	4	yes	yes	INTJ
admet-291	249	1	no	no	DET
admet-291	249	2	docetaxel	docetaxel	NOUN
admet-291	250	1	no	no	INTJ
admet-291	251	1	yes	yes	INTJ
admet-291	251	2	-0.172	-0.172	PRON
admet-291	252	1	no	no	INTJ
admet-291	252	2	no	no	INTJ
admet-291	253	1	no	no	DET
admet-291	253	2	1.617	1.617	NUM
admet-291	253	3	2.808	2.808	NUM
admet-291	253	4	yes	yes	INTJ
admet-291	254	1	no	no	DET
admet-291	254	2	etoposide	etoposide	NOUN
admet-291	254	3	no	no	INTJ
admet-291	254	4	no	no	DET
admet-291	254	5	0.041	0.041	NUM
admet-291	254	6	no	no	INTJ
admet-291	254	7	no	no	INTJ
admet-291	254	8	no	no	DET
admet-291	254	9	2.071	2.071	NUM
admet-291	254	10	2.331	2.331	NUM
admet-291	254	11	no	no	INTJ
admet-291	255	1	no	no	DET
admet-291	255	2	irinotecan	irinotecan	NOUN
admet-291	256	1	no	no	INTJ
admet-291	256	2	yes	yes	INTJ
admet-291	257	1	1.213	1.213	NUM
admet-291	257	2	no	no	INTJ
admet-291	257	3	no	no	INTJ
admet-291	257	4	no	no	DET
admet-291	257	5	2.766	2.766	NUM
admet-291	257	6	1.693	1.693	NUM
admet-291	257	7	yes	yes	INTJ
admet-291	257	8	no	no	DET
admet-291	257	9	paclitaxel	paclitaxel	NOUN
admet-291	258	1	no	no	INTJ
admet-291	258	2	yes	yes	INTJ
admet-291	258	3	-0.121	-0.121	NOUN
admet-291	259	1	no	no	INTJ
admet-291	259	2	no	no	INTJ
admet-291	259	3	no	no	DET
admet-291	259	4	1.708	1.708	NUM
admet-291	259	5	3.081	3.081	NUM
admet-291	260	1	no	no	INTJ
admet-291	260	2	no	no	DET
admet-291	260	3	teniposide	teniposide	NOUN
admet-291	260	4	no	no	INTJ
admet-291	261	1	yes	yes	INTJ
admet-291	261	2	0.409	0.409	NUM
admet-291	262	1	no	no	INTJ
admet-291	262	2	no	no	INTJ
admet-291	262	3	no	no	DET
admet-291	262	4	2.162	2.162	NUM
admet-291	262	5	2.689	2.689	NUM
admet-291	262	6	no	no	INTJ
admet-291	262	7	no	no	DET
admet-291	262	8	topotecan	topotecan	NOUN
admet-291	263	1	no	no	INTJ
admet-291	263	2	no	no	DET
admet-291	263	3	1.196	1.196	NUM
admet-291	263	4	no	no	INTJ
admet-291	263	5	yes	yes	INTJ
admet-291	264	1	no	no	DET
admet-291	264	2	2.58	2.58	NUM
admet-291	264	3	1.867	1.867	NUM
admet-291	264	4	yes	yes	INTJ
admet-291	265	1	no	no	DET
admet-291	265	2	vinblastine	vinblastine	NOUN
admet-291	266	1	no	no	INTJ
admet-291	266	2	yes	yes	INTJ
admet-291	266	3	0.618	0.618	NUM
admet-291	267	1	no	no	INTJ
admet-291	267	2	no	no	INTJ
admet-291	267	3	no	no	DET
admet-291	267	4	2.251	2.251	NUM
admet-291	267	5	2.588	2.588	NUM
admet-291	267	6	yes	yes	INTJ
admet-291	268	1	no	no	DET
admet-291	268	2	vincristine	vincristine	NOUN
admet-291	269	1	no	no	INTJ
admet-291	269	2	yes	yes	INTJ
admet-291	269	3	0.739	0.739	NUM
admet-291	269	4	no	no	INTJ
admet-291	270	1	no	no	INTJ
admet-291	270	2	no	no	DET
admet-291	270	3	2.11	2.11	NUM
admet-291	270	4	2.67	2.67	NUM
admet-291	271	1	yes	yes	INTJ
admet-291	272	1	no	no	DET
admet-291	272	2	vinorelbine	vinorelbine	NOUN
admet-291	272	3	no	no	INTJ
admet-291	273	1	yes	yes	INTJ
admet-291	273	2	0.622	0.622	NUM
admet-291	274	1	no	no	INTJ
admet-291	274	2	no	no	INTJ
admet-291	275	1	no	no	PRON
admet-291	275	2	2.343	2.343	NUM
admet-291	275	3	2.5	2.5	NUM
admet-291	276	1	yes	yes	INTJ
admet-291	277	1	no	no	DET
admet-291	277	2	amrubicin	amrubicin	NOUN
admet-291	278	1	no	no	INTJ
admet-291	278	2	yes	yes	INTJ
admet-291	278	3	0.4	0.4	NUM
admet-291	279	1	no	no	INTJ
admet-291	279	2	no	no	INTJ
admet-291	279	3	no	no	DET
admet-291	279	4	2.531	2.531	NUM
admet-291	279	5	1.721	1.721	NUM
admet-291	279	6	no	no	INTJ
admet-291	280	1	no	no	INTJ
admet-291	280	2	arglabin	arglabin	NOUN
admet-291	281	1	no	no	INTJ
admet-291	281	2	yes	yes	INTJ
admet-291	281	3	1.059	1.059	NUM
admet-291	282	1	no	no	INTJ
admet-291	282	2	yes	yes	INTJ
admet-291	282	3	no	no	DET
admet-291	282	4	2.022	2.022	NUM
admet-291	282	5	2.103	2.103	NUM
admet-291	282	6	no	no	DET
admet-291	282	7	no	no	DET
admet-291	282	8	carfilzomib	carfilzomib	NOUN
admet-291	283	1	no	no	INTJ
admet-291	283	2	no	no	DET
admet-291	283	3	0.839	0.839	NUM
admet-291	283	4	no	no	INTJ
admet-291	283	5	no	no	INTJ
admet-291	283	6	no	no	DET
admet-291	283	7	1.986	1.986	NUM
admet-291	283	8	1.482	1.482	NUM
admet-291	283	9	no	no	PRON
admet-291	283	10	no	no	DET
admet-291	283	11	combretastatin	combretastatin	NOUN
admet-291	284	1	no	no	INTJ
admet-291	284	2	yes	yes	INTJ
admet-291	284	3	1.564	1.564	NUM
admet-291	284	4	no	no	INTJ
admet-291	284	5	no	no	INTJ
admet-291	285	1	no	no	DET
admet-291	285	2	2.162	2.162	NUM
admet-291	285	3	3.012	3.012	NUM
admet-291	286	1	yes	yes	INTJ
admet-291	287	1	no	no	INTJ
admet-291	287	2	ellipticine	ellipticine	NOUN
admet-291	288	1	no	no	INTJ
admet-291	289	1	yes	yes	INTJ
admet-291	289	2	0.222	0.222	NUM
admet-291	289	3	no	no	INTJ
admet-291	289	4	no	no	INTJ
admet-291	290	1	no	no	DET
admet-291	290	2	2.076	2.076	NUM
admet-291	290	3	2.104	2.104	NUM
admet-291	290	4	no	no	DET
admet-291	291	1	no	no	DET
admet-291	291	2	exemestane	exemestane	NOUN
admet-291	291	3	no	no	INTJ
admet-291	292	1	yes	yes	ADV
admet-291	292	2	0.543	0.543	NUM
admet-291	293	1	no	no	INTJ
admet-291	293	2	no	no	INTJ
admet-291	293	3	no	no	DET
admet-291	293	4	2.712	2.712	NUM
admet-291	293	5	1.522	1.522	NUM
admet-291	294	1	no	no	INTJ
admet-291	294	2	no	no	ADV
admet-291	294	3	formestane	formestane	NOUN
admet-291	295	1	no	no	INTJ
admet-291	295	2	yes	yes	INTJ
admet-291	295	3	0.832	0.832	NUM
admet-291	296	1	no	no	INTJ
admet-291	296	2	no	no	INTJ
admet-291	296	3	no	no	DET
admet-291	296	4	2.062	2.062	NUM
admet-291	296	5	1.822	1.822	NUM
admet-291	296	6	no	no	INTJ
admet-291	297	1	no	no	DET
admet-291	297	2	homoharringtonine	homoharringtonine	NOUN
admet-291	298	1	no	no	INTJ
admet-291	298	2	yes	yes	INTJ
admet-291	298	3	0.64	0.64	NUM
admet-291	299	1	no	no	INTJ
admet-291	299	2	no	no	INTJ
admet-291	299	3	no	no	PRON
admet-291	299	4	2.214	2.214	NUM
admet-291	299	5	1.918	1.918	NUM
admet-291	299	6	no	no	INTJ
admet-291	300	1	no	no	DET
admet-291	300	2	podophyllotoxin	podophyllotoxin	NOUN
admet-291	300	3	no	no	INTJ
admet-291	301	1	yes	yes	INTJ
admet-291	301	2	1.543	1.543	NUM
admet-291	302	1	no	no	INTJ
admet-291	303	1	no	no	INTJ
admet-291	303	2	no	no	DET
admet-291	303	3	2.162	2.162	NUM
admet-291	303	4	1.86	1.86	NUM
admet-291	304	1	yes	yes	INTJ
admet-291	305	1	no	no	DET
admet-291	305	2	rohitukine	rohitukine	NOUN
admet-291	306	1	no	no	INTJ
admet-291	306	2	yes	yes	INTJ
admet-291	306	3	0.14	0.14	NUM
admet-291	307	1	no	no	INTJ
admet-291	307	2	no	no	INTJ
admet-291	307	3	no	no	DET
admet-291	307	4	2.205	2.205	NUM
admet-291	307	5	2.284	2.284	NUM
admet-291	307	6	no	no	INTJ
admet-291	308	1	no	no	INTJ
admet-291	308	2	roscovitine	roscovitine	NOUN
admet-291	309	1	no	no	INTJ
admet-291	309	2	yes	yes	INTJ
admet-291	309	3	0.495	0.495	NUM
admet-291	310	1	no	no	INTJ
admet-291	311	1	yes	yes	INTJ
admet-291	311	2	no	no	PRON
admet-291	311	3	2.448	2.448	NUM
admet-291	311	4	1.607	1.607	NUM
admet-291	312	1	yes	yes	INTJ
admet-291	313	1	no	no	DET
admet-291	313	2	vindesine	vindesine	NOUN
admet-291	314	1	no	no	INTJ
admet-291	314	2	yes	yes	INTJ
admet-291	314	3	1.174	1.174	NUM
admet-291	315	1	no	no	INTJ
admet-291	315	2	no	no	INTJ
admet-291	315	3	no	no	DET
admet-291	315	4	2.761	2.761	NUM
admet-291	315	5	1.683	1.683	NUM
admet-291	315	6	yes	yes	INTJ
admet-291	315	7	no	no	DET
admet-291	315	8	vinflunine	vinflunine	NOUN
admet-291	316	1	no	no	INTJ
admet-291	316	2	yes	yes	INTJ
admet-291	316	3	0.467	0.467	NUM
admet-291	317	1	no	no	INTJ
admet-291	317	2	no	no	INTJ
admet-291	317	3	no	no	PRON
admet-291	317	4	2.414	2.414	NUM
admet-291	317	5	2.729	2.729	NUM
admet-291	317	6	yes	yes	INTJ
admet-291	317	7	no	no	DET
admet-291	317	8	amrubicin	amrubicin	NOUN
admet-291	318	1	no	no	INTJ
admet-291	318	2	yes	yes	INTJ
admet-291	318	3	0.365	0.365	NUM
admet-291	319	1	no	no	INTJ
admet-291	319	2	no	no	INTJ
admet-291	319	3	no	no	DET
admet-291	319	4	2.311	2.311	NUM
admet-291	319	5	2.267	2.267	NUM
admet-291	320	1	no	no	DET
admet-291	320	2	no	no	DET
admet-291	320	3	admet	admet	NOUN
admet-291	320	4	&	&	CCONJ
admet-291	320	5	dmpk	dmpk	PROPN
admet-291	320	6	4(2	4(2	NUM
admet-291	320	7	)	)	PUNCT
admet-291	320	8	(	(	PUNCT
admet-291	320	9	2016	2016	NUM
admet-291	320	10	)	)	PUNCT
admet-291	320	11	98	98	NUM
admet-291	320	12	-	-	SYM
admet-291	320	13	113	113	NUM
admet-291	320	14	defining	define	VERB
admet-291	320	15	natural	natural	ADJ
admet-291	320	16	product	product	NOUN
admet-291	320	17	derived	derive	VERB
admet-291	320	18	anticancer	anticancer	NOUN
admet-291	320	19	drug	drug	NOUN
admet-291	320	20	space	space	NOUN
admet-291	320	21	doi	doi	NOUN
admet-291	320	22	:	:	PUNCT
admet-291	320	23	10.5599	10.5599	NUM
admet-291	320	24	/	/	SYM
admet-291	320	25	admet.4.2.291	admet.4.2.291	DET
admet-291	320	26	112	112	NUM
admet-291	320	27	conclusions	conclusion	NOUN
admet-291	320	28	3	3	NUM
admet-291	320	29	improving	improve	VERB
admet-291	320	30	the	the	DET
admet-291	320	31	survival	survival	NOUN
admet-291	320	32	rate	rate	NOUN
admet-291	320	33	of	of	ADP
admet-291	320	34	clinical	clinical	ADJ
admet-291	320	35	candidates	candidate	NOUN
admet-291	320	36	and	and	CCONJ
admet-291	320	37	reducing	reduce	VERB
admet-291	320	38	the	the	DET
admet-291	320	39	drug	drug	NOUN
admet-291	320	40	attrition	attrition	NOUN
admet-291	320	41	is	be	AUX
admet-291	320	42	governed	govern	VERB
admet-291	320	43	by	by	ADP
admet-291	320	44	multi-4	multi-4	NOUN
admet-291	320	45	factors	factor	NOUN
admet-291	320	46	,	,	PUNCT
admet-291	320	47	and	and	CCONJ
admet-291	320	48	thus	thus	ADV
admet-291	320	49	,	,	PUNCT
admet-291	320	50	a	a	DET
admet-291	320	51	holistic	holistic	ADJ
admet-291	320	52	strategy	strategy	NOUN
admet-291	320	53	that	that	PRON
admet-291	320	54	addresses	address	VERB
admet-291	320	55	key	key	ADJ
admet-291	320	56	attrition	attrition	NOUN
admet-291	320	57	factors	factor	NOUN
admet-291	320	58	(	(	PUNCT
admet-291	320	59	safety	safety	NOUN
admet-291	320	60	,	,	PUNCT
admet-291	320	61	adme	adme	NOUN
admet-291	320	62	,	,	PUNCT
admet-291	320	63	and	and	CCONJ
admet-291	320	64	efficacy	efficacy	NOUN
admet-291	320	65	)	)	PUNCT
admet-291	320	66	.	.	PUNCT
admet-291	321	1	5	5	NUM
admet-291	321	2	chemical	chemical	NOUN
admet-291	321	3	space	space	NOUN
admet-291	321	4	defined	define	VERB
admet-291	321	5	by	by	ADP
admet-291	321	6	physicochemical	physicochemical	ADJ
admet-291	321	7	properties	property	NOUN
admet-291	321	8	is	be	AUX
admet-291	321	9	vast	vast	ADJ
admet-291	321	10	,	,	PUNCT
admet-291	321	11	yet	yet	CCONJ
admet-291	321	12	there	there	PRON
admet-291	321	13	are	be	VERB
admet-291	321	14	several	several	ADJ
admet-291	321	15	design	design	NOUN
admet-291	321	16	parameters	parameter	NOUN
admet-291	321	17	that	that	SCONJ
admet-291	321	18	6	6	NUM
admet-291	321	19	medicinal	medicinal	ADJ
admet-291	321	20	chemists	chemist	NOUN
admet-291	321	21	can	can	AUX
admet-291	321	22	follow	follow	VERB
admet-291	321	23	when	when	SCONJ
admet-291	321	24	designing	design	VERB
admet-291	321	25	druglike	druglike	NOUN
admet-291	321	26	compounds	compound	NOUN
admet-291	321	27	(	(	PUNCT
admet-291	321	28	e.g.	e.g.	ADV
admet-291	321	29	,	,	PUNCT
admet-291	321	30	lipinski	lipinski	PROPN
admet-291	321	31	’s	’s	PART
admet-291	321	32	rule	rule	NOUN
admet-291	321	33	of	of	ADP
admet-291	321	34	five	five	NUM
admet-291	321	35	)	)	PUNCT
admet-291	321	36	and	and	CCONJ
admet-291	321	37	7	7	NUM
admet-291	321	38	defining	define	VERB
admet-291	321	39	the	the	DET
admet-291	321	40	parameters	parameter	NOUN
admet-291	321	41	that	that	PRON
admet-291	321	42	increase	increase	VERB
admet-291	321	43	the	the	DET
admet-291	321	44	likelihood	likelihood	NOUN
admet-291	321	45	of	of	ADP
admet-291	321	46	identifying	identify	VERB
admet-291	321	47	best	well	ADV
admet-291	321	48	in	in	ADP
admet-291	321	49	class	class	NOUN
admet-291	321	50	molecules	molecule	NOUN
admet-291	321	51	is	be	AUX
admet-291	321	52	of	of	ADP
admet-291	321	53	critical	critical	ADJ
admet-291	321	54	8	8	NUM
admet-291	321	55	importance	importance	NOUN
admet-291	321	56	.	.	PUNCT
admet-291	322	1	understanding	understand	VERB
admet-291	322	2	the	the	DET
admet-291	322	3	fundamental	fundamental	ADJ
admet-291	322	4	relationships	relationship	NOUN
admet-291	322	5	between	between	ADP
admet-291	322	6	physicochemical	physicochemical	ADJ
admet-291	322	7	properties	property	NOUN
admet-291	322	8	and	and	CCONJ
admet-291	322	9	in	in	ADP
admet-291	322	10	vitro	vitro	X
admet-291	322	11	9	9	NUM
admet-291	322	12	and	and	CCONJ
admet-291	322	13	in	in	ADP
admet-291	322	14	vivo	vivo	NOUN
admet-291	322	15	results	result	NOUN
admet-291	322	16	is	be	AUX
admet-291	322	17	primary	primary	ADJ
admet-291	322	18	need	need	NOUN
admet-291	322	19	to	to	PART
admet-291	322	20	prospectively	prospectively	VERB
admet-291	322	21	design	design	VERB
admet-291	322	22	compounds	compound	NOUN
admet-291	322	23	with	with	ADP
admet-291	322	24	an	an	DET
admet-291	322	25	overall	overall	ADJ
admet-291	322	26	desired	desire	VERB
admet-291	322	27	profile	profile	NOUN
admet-291	322	28	.	.	PUNCT
admet-291	323	1	as	as	ADP
admet-291	323	2	10	10	NUM
admet-291	323	3	part	part	NOUN
admet-291	323	4	of	of	ADP
admet-291	323	5	our	our	PRON
admet-291	323	6	efforts	effort	NOUN
admet-291	323	7	to	to	PART
admet-291	323	8	further	far	ADV
admet-291	323	9	build	build	VERB
admet-291	323	10	this	this	DET
admet-291	323	11	understanding	understanding	NOUN
admet-291	323	12	in	in	ADP
admet-291	323	13	the	the	DET
admet-291	323	14	anticancer	anticancer	NOUN
admet-291	323	15	drug	drug	NOUN
admet-291	323	16	development	development	NOUN
admet-291	323	17	space	space	NOUN
admet-291	323	18	,	,	PUNCT
admet-291	323	19	we	we	PRON
admet-291	323	20	11	11	NUM
admet-291	323	21	undertook	undertake	VERB
admet-291	323	22	a	a	DET
admet-291	323	23	thorough	thorough	ADJ
admet-291	323	24	analysis	analysis	NOUN
admet-291	323	25	of	of	ADP
admet-291	323	26	the	the	DET
admet-291	323	27	physicochemical	physicochemical	ADJ
admet-291	323	28	properties	property	NOUN
admet-291	323	29	,	,	PUNCT
admet-291	323	30	adme	adme	NOUN
admet-291	323	31	attributes	attribute	NOUN
admet-291	323	32	,	,	PUNCT
admet-291	323	33	and	and	CCONJ
admet-291	323	34	safety	safety	NOUN
admet-291	323	35	end	end	NOUN
admet-291	323	36	points	point	NOUN
admet-291	323	37	12	12	NUM
admet-291	323	38	for	for	ADP
admet-291	323	39	24	24	NUM
admet-291	323	40	natural	natural	ADJ
admet-291	323	41	product	product	NOUN
admet-291	323	42	derived	derive	VERB
admet-291	323	43	anticancer	anticancer	NOUN
admet-291	323	44	drugs	drug	NOUN
admet-291	323	45	and	and	CCONJ
admet-291	323	46	27	27	NUM
admet-291	323	47	natural	natural	ADJ
admet-291	323	48	product	product	NOUN
admet-291	323	49	lead	lead	NOUN
admet-291	323	50	candidates	candidate	NOUN
admet-291	323	51	.	.	PUNCT
admet-291	324	1	we	we	PRON
admet-291	324	2	examined	examine	VERB
admet-291	324	3	a	a	DET
admet-291	324	4	13	13	NUM
admet-291	324	5	comparison	comparison	NOUN
admet-291	324	6	of	of	ADP
admet-291	324	7	eight	eight	NUM
admet-291	324	8	fundamental	fundamental	ADJ
admet-291	324	9	physicochemical	physicochemical	ADJ
admet-291	324	10	properties	property	NOUN
admet-291	324	11	associated	associate	VERB
admet-291	324	12	with	with	ADP
admet-291	324	13	these	these	DET
admet-291	324	14	two	two	NUM
admet-291	324	15	sets	set	NOUN
admet-291	324	16	of	of	ADP
admet-291	324	17	14	14	NUM
admet-291	324	18	compounds	compound	NOUN
admet-291	324	19	:	:	PUNCT
admet-291	324	20	log	log	VERB
admet-291	324	21	p	p	NOUN
admet-291	324	22	,	,	PUNCT
admet-291	324	23	log	log	NOUN
admet-291	324	24	d	d	NOUN
admet-291	324	25	,	,	PUNCT
admet-291	324	26	mw	mw	X
admet-291	324	27	,	,	PUNCT
admet-291	324	28	tpsa	tpsa	PROPN
admet-291	324	29	,	,	PUNCT
admet-291	324	30	hbd	hbd	NOUN
admet-291	324	31	,	,	PUNCT
admet-291	324	32	hba	hba	PROPN
admet-291	324	33	,	,	PUNCT
admet-291	324	34	log	log	NOUN
admet-291	324	35	s	s	PRON
admet-291	324	36	and	and	CCONJ
admet-291	324	37	nrot	nrot	NOUN
admet-291	324	38	.	.	PUNCT
admet-291	325	1	the	the	DET
admet-291	325	2	anticancer	anticancer	NOUN
admet-291	325	3	drug	drug	NOUN
admet-291	325	4	space	space	NOUN
admet-291	325	5	defined	define	VERB
admet-291	325	6	by	by	ADP
admet-291	325	7	these	these	DET
admet-291	325	8	15	15	NUM
admet-291	325	9	physicochemical	physicochemical	ADJ
admet-291	325	10	properties	property	NOUN
admet-291	325	11	is	be	AUX
admet-291	325	12	pretty	pretty	ADV
admet-291	325	13	broad	broad	ADJ
admet-291	325	14	,	,	PUNCT
admet-291	325	15	but	but	CCONJ
admet-291	325	16	our	our	PRON
admet-291	325	17	analysis	analysis	NOUN
admet-291	325	18	identified	identify	VERB
admet-291	325	19	the	the	DET
admet-291	325	20	optimum	optimum	ADJ
admet-291	325	21	ranges	range	NOUN
admet-291	325	22	for	for	ADP
admet-291	325	23	each	each	PRON
admet-291	325	24	of	of	ADP
admet-291	325	25	16	16	NUM
admet-291	325	26	these	these	DET
admet-291	325	27	properties	property	NOUN
admet-291	325	28	.	.	PUNCT
admet-291	326	1	the	the	DET
admet-291	326	2	optimal	optimal	ADJ
admet-291	326	3	property	property	NOUN
admet-291	326	4	ranges	range	NOUN
admet-291	326	5	(	(	PUNCT
admet-291	326	6	covering	cover	VERB
admet-291	326	7	almost	almost	ADV
admet-291	326	8	~80	~80	NOUN
admet-291	326	9	%	%	NOUN
admet-291	326	10	or	or	CCONJ
admet-291	326	11	more	more	ADJ
admet-291	326	12	of	of	ADP
admet-291	326	13	the	the	DET
admet-291	326	14	anticancer	anticancer	NOUN
admet-291	326	15	drugs	drug	NOUN
admet-291	326	16	)	)	PUNCT
admet-291	326	17	17	17	NUM
admet-291	326	18	were	be	AUX
admet-291	326	19	found	find	VERB
admet-291	326	20	to	to	PART
admet-291	326	21	be	be	AUX
admet-291	326	22	200	200	NUM
admet-291	326	23	<	<	X
admet-291	326	24	mw	mw	X
admet-291	326	25	≤	≤	NUM
admet-291	326	26	800	800	NUM
admet-291	326	27	da	da	NOUN
admet-291	326	28	,	,	PUNCT
admet-291	326	29	1	1	NUM
admet-291	326	30	<	<	X
admet-291	326	31	log	log	NOUN
admet-291	326	32	p	p	NOUN
admet-291	326	33	≤	≤	NUM
admet-291	326	34	5	5	NUM
admet-291	326	35	,	,	PUNCT
admet-291	326	36	-6	-6	PROPN
admet-291	326	37	≤	≤	NUM
admet-291	326	38	clog	clog	NOUN
admet-291	326	39	s	s	PART
admet-291	326	40	≤	≤	NOUN
admet-291	326	41	-1	-1	PUNCT
admet-291	326	42	,	,	PUNCT
admet-291	326	43	5	5	NUM
admet-291	326	44	≤	≤	NUM
admet-291	326	45	hba	hba	X
admet-291	326	46	≤	≤	ADV
admet-291	326	47	13	13	NUM
admet-291	326	48	,	,	PUNCT
admet-291	326	49	1	1	NUM
admet-291	326	50	≤	≤	NUM
admet-291	326	51	hbd	hbd	NOUN
admet-291	326	52	≤	≤	ADV
admet-291	326	53	5	5	NUM
admet-291	326	54	,	,	PUNCT
admet-291	326	55	50	50	NUM
admet-291	326	56	≤	≤	NUM
admet-291	326	57	tpsa	tpsa	NOUN
admet-291	326	58	≤	≤	NUM
admet-291	326	59	18	18	NUM
admet-291	326	60	180	180	NUM
admet-291	326	61	å2	å2	NOUN
admet-291	326	62	,	,	PUNCT
admet-291	326	63	0	0	NUM
admet-291	326	64	≤	≤	NUM
admet-291	326	65	nrot	nrot	NOUN
admet-291	326	66	≤	≤	ADV
admet-291	326	67	10	10	NUM
admet-291	326	68	,	,	PUNCT
admet-291	326	69	log	log	NOUN
admet-291	326	70	d=2.8	d=2.8	ADJ
admet-291	326	71	.	.	PUNCT
admet-291	327	1	analysis	analysis	NOUN
admet-291	327	2	of	of	ADP
admet-291	327	3	in	in	ADP
admet-291	327	4	silico	silico	NOUN
admet-291	327	5	generated	generate	VERB
admet-291	327	6	adme	adme	NOUN
admet-291	327	7	data	datum	NOUN
admet-291	327	8	reinforced	reinforce	VERB
admet-291	327	9	that	that	SCONJ
admet-291	327	10	the	the	DET
admet-291	327	11	majority	majority	NOUN
admet-291	327	12	of	of	ADP
admet-291	327	13	19	19	NUM
admet-291	327	14	anticancer	anticancer	NOUN
admet-291	327	15	drugs	drug	NOUN
admet-291	327	16	(	(	PUNCT
admet-291	327	17	70	70	NUM
admet-291	327	18	%	%	NOUN
admet-291	327	19	)	)	PUNCT
admet-291	327	20	are	be	AUX
admet-291	327	21	low	low	ADV
admet-291	327	22	permeable	permeable	ADJ
admet-291	327	23	(	(	PUNCT
admet-291	327	24	caco2	caco2	NOUN
admet-291	327	25	of	of	ADP
admet-291	327	26	log	log	NOUN
admet-291	327	27	papp	papp	NOUN
admet-291	327	28	(	(	PUNCT
admet-291	327	29	in	in	ADP
admet-291	327	30	10	10	NUM
admet-291	327	31	-	-	SYM
admet-291	327	32	6	6	NUM
admet-291	327	33	cm	cm	NOUN
admet-291	327	34	/	/	SYM
admet-291	327	35	s	s	NOUN
admet-291	327	36	)	)	PUNCT
admet-291	327	37	<	<	X
admet-291	327	38	0.9	0.9	NUM
admet-291	327	39	)	)	PUNCT
admet-291	327	40	,	,	PUNCT
admet-291	327	41	and	and	CCONJ
admet-291	327	42	also	also	ADV
admet-291	327	43	all	all	DET
admet-291	327	44	drugs	drug	NOUN
admet-291	327	45	are	be	AUX
admet-291	327	46	20	20	NUM
admet-291	327	47	considered	consider	VERB
admet-291	327	48	to	to	PART
admet-291	327	49	be	be	AUX
admet-291	327	50	p	p	NOUN
admet-291	327	51	-	-	PUNCT
admet-291	327	52	gp	gp	NOUN
admet-291	327	53	efflux	efflux	NOUN
admet-291	327	54	substrates	substrate	NOUN
admet-291	327	55	,	,	PUNCT
admet-291	327	56	and	and	CCONJ
admet-291	327	57	with	with	ADP
admet-291	327	58	low	low	ADJ
admet-291	327	59	to	to	ADP
admet-291	327	60	moderate	moderate	ADJ
admet-291	327	61	clearance	clearance	NOUN
admet-291	327	62	rates	rate	NOUN
admet-291	327	63	.	.	PUNCT
admet-291	328	1	21	21	NUM
admet-291	328	2	on	on	ADP
admet-291	328	3	the	the	DET
admet-291	328	4	other	other	ADJ
admet-291	328	5	hand	hand	NOUN
admet-291	328	6	,	,	PUNCT
admet-291	328	7	our	our	PRON
admet-291	328	8	analysis	analysis	NOUN
admet-291	328	9	showed	show	VERB
admet-291	328	10	that	that	SCONJ
admet-291	328	11	for	for	ADP
admet-291	328	12	anticancer	anticancer	NOUN
admet-291	328	13	drugs	drug	NOUN
admet-291	328	14	,	,	PUNCT
admet-291	328	15	there	there	PRON
admet-291	328	16	may	may	AUX
admet-291	328	17	be	be	AUX
admet-291	328	18	a	a	DET
admet-291	328	19	need	need	NOUN
admet-291	328	20	to	to	PART
admet-291	328	21	optimize	optimize	VERB
admet-291	328	22	new	new	ADJ
admet-291	328	23	22	22	NUM
admet-291	328	24	compounds	compound	NOUN
admet-291	328	25	with	with	ADP
admet-291	328	26	further	further	ADJ
admet-291	328	27	reduced	reduce	VERB
admet-291	328	28	mw	mw	PROPN
admet-291	328	29	,	,	PUNCT
admet-291	328	30	hba	hba	NOUN
admet-291	328	31	,	,	PUNCT
admet-291	328	32	and	and	CCONJ
admet-291	328	33	nrot	nrot	VERB
admet-291	328	34	to	to	PART
admet-291	328	35	better	well	ADV
admet-291	328	36	match	match	VERB
admet-291	328	37	the	the	DET
admet-291	328	38	corresponding	correspond	VERB
admet-291	328	39	properties	property	NOUN
admet-291	328	40	in	in	ADP
admet-291	328	41	the	the	DET
admet-291	328	42	23	23	NUM
admet-291	328	43	marketed	market	VERB
admet-291	328	44	drug	drug	NOUN
admet-291	328	45	set	set	NOUN
admet-291	328	46	.	.	PUNCT
admet-291	329	1	in	in	ADP
admet-291	329	2	addition	addition	NOUN
admet-291	329	3	,	,	PUNCT
admet-291	329	4	we	we	PRON
admet-291	329	5	have	have	AUX
admet-291	329	6	established	establish	VERB
admet-291	329	7	meaningful	meaningful	ADJ
admet-291	329	8	correlations	correlation	NOUN
admet-291	329	9	between	between	ADP
admet-291	329	10	the	the	DET
admet-291	329	11	physicochemical	physicochemical	ADJ
admet-291	329	12	24	24	NUM
admet-291	329	13	properties	property	NOUN
admet-291	329	14	specially	specially	ADV
admet-291	329	15	hba	hba	NOUN
admet-291	329	16	,	,	PUNCT
admet-291	329	17	hbd	hbd	NOUN
admet-291	329	18	,	,	PUNCT
admet-291	329	19	and	and	CCONJ
admet-291	329	20	tpsa	tpsa	NOUN
admet-291	329	21	and	and	CCONJ
admet-291	329	22	adme	adme	NOUN
admet-291	329	23	attributes	attribute	NOUN
admet-291	329	24	of	of	ADP
admet-291	329	25	the	the	DET
admet-291	329	26	molecules	molecule	NOUN
admet-291	329	27	that	that	PRON
admet-291	329	28	might	might	AUX
admet-291	329	29	be	be	AUX
admet-291	329	30	generally	generally	ADV
admet-291	329	31	25	25	NUM
admet-291	329	32	applicable	applicable	ADJ
admet-291	329	33	for	for	ADP
admet-291	329	34	the	the	DET
admet-291	329	35	future	future	ADJ
admet-291	329	36	anticancer	anticancer	NOUN
admet-291	329	37	drug	drug	NOUN
admet-291	329	38	development	development	NOUN
admet-291	329	39	and	and	CCONJ
admet-291	329	40	optimization	optimization	NOUN
admet-291	329	41	of	of	ADP
admet-291	329	42	the	the	DET
admet-291	329	43	natural	natural	ADJ
admet-291	329	44	product	product	NOUN
admet-291	329	45	derived	derive	VERB
admet-291	329	46	26	26	NUM
admet-291	329	47	anticancer	anticancer	NOUN
admet-291	329	48	leads	lead	VERB
admet-291	329	49	/	/	SYM
admet-291	329	50	clinical	clinical	ADJ
admet-291	329	51	candidates	candidate	NOUN
admet-291	329	52	.	.	PUNCT
admet-291	330	1	our	our	PRON
admet-291	330	2	study	study	NOUN
admet-291	330	3	showed	show	VERB
admet-291	330	4	the	the	DET
admet-291	330	5	meaningful	meaningful	ADJ
admet-291	330	6	correlations	correlation	NOUN
admet-291	330	7	between	between	ADP
admet-291	330	8	27	27	NUM
admet-291	330	9	physicochemical	physicochemical	ADJ
admet-291	330	10	properties	property	NOUN
admet-291	330	11	and	and	CCONJ
admet-291	330	12	toxicity	toxicity	NOUN
admet-291	330	13	profile	profile	NOUN
admet-291	330	14	of	of	ADP
admet-291	330	15	compounds	compound	NOUN
admet-291	330	16	.	.	PUNCT
admet-291	331	1	log	log	VERB
admet-291	331	2	p	p	NOUN
admet-291	331	3	and	and	CCONJ
admet-291	331	4	mw	mw	PROPN
admet-291	331	5	are	be	AUX
admet-291	331	6	most	most	ADV
admet-291	331	7	critical	critical	ADJ
admet-291	331	8	28	28	NUM
admet-291	331	9	physicochemical	physicochemical	ADJ
admet-291	331	10	parameter	parameter	NOUN
admet-291	331	11	and	and	CCONJ
admet-291	331	12	robust	robust	ADJ
admet-291	331	13	predictor	predictor	NOUN
admet-291	331	14	of	of	ADP
admet-291	331	15	toxicity	toxicity	NOUN
admet-291	331	16	profile	profile	NOUN
admet-291	331	17	of	of	ADP
admet-291	331	18	anticancer	anticancer	NOUN
admet-291	331	19	leads	lead	VERB
admet-291	331	20	/	/	SYM
admet-291	331	21	clinical	clinical	ADJ
admet-291	331	22	candidates	candidate	NOUN
admet-291	331	23	29	29	NUM
admet-291	331	24	we	we	PRON
admet-291	331	25	showed	show	VERB
admet-291	331	26	by	by	ADP
admet-291	331	27	our	our	PRON
admet-291	331	28	analysis	analysis	NOUN
admet-291	331	29	that	that	SCONJ
admet-291	331	30	early	early	ADJ
admet-291	331	31	prediction	prediction	NOUN
admet-291	331	32	of	of	ADP
admet-291	331	33	physicochemical	physicochemical	ADJ
admet-291	331	34	properties	property	NOUN
admet-291	331	35	,	,	PUNCT
admet-291	331	36	adme	adme	NOUN
admet-291	331	37	attributes	attribute	NOUN
admet-291	331	38	,	,	PUNCT
admet-291	331	39	and	and	CCONJ
admet-291	331	40	30	30	NUM
admet-291	331	41	safety	safety	NOUN
admet-291	331	42	attributes	attribute	VERB
admet-291	331	43	through	through	ADP
admet-291	331	44	in	in	ADP
admet-291	331	45	silico	silico	NOUN
admet-291	331	46	tools	tool	NOUN
admet-291	331	47	are	be	AUX
admet-291	331	48	all	all	PRON
admet-291	331	49	important	important	ADJ
admet-291	331	50	parameters	parameter	NOUN
admet-291	331	51	to	to	PART
admet-291	331	52	enable	enable	VERB
admet-291	331	53	better	well	ADJ
admet-291	331	54	lead	lead	ADJ
admet-291	331	55	candidate	candidate	NOUN
admet-291	331	56	31	31	NUM
admet-291	331	57	selections	selection	NOUN
admet-291	331	58	,	,	PUNCT
admet-291	331	59	saving	save	VERB
admet-291	331	60	considerable	considerable	ADJ
admet-291	331	61	time	time	NOUN
admet-291	331	62	and	and	CCONJ
admet-291	331	63	effort	effort	NOUN
admet-291	331	64	in	in	ADP
admet-291	331	65	the	the	DET
admet-291	331	66	anticancer	anticancer	NOUN
admet-291	331	67	drug	drug	NOUN
admet-291	331	68	development	development	NOUN
admet-291	331	69	.	.	PUNCT
admet-291	332	1	32	32	NUM
admet-291	332	2	33	33	NUM
admet-291	332	3	acknowledgements	acknowledgement	NOUN
admet-291	332	4	:	:	PUNCT
admet-291	332	5	author	author	NOUN
admet-291	332	6	is	be	AUX
admet-291	332	7	thankful	thankful	ADJ
admet-291	332	8	to	to	ADP
admet-291	332	9	the	the	DET
admet-291	332	10	director	director	NOUN
admet-291	332	11	,	,	PUNCT
admet-291	332	12	central	central	PROPN
admet-291	332	13	institute	institute	PROPN
admet-291	332	14	of	of	ADP
admet-291	332	15	medicinal	medicinal	ADJ
admet-291	332	16	and	and	CCONJ
admet-291	332	17	aromatic	aromatic	ADJ
admet-291	332	18	plants	plant	NOUN
admet-291	332	19	34	34	NUM
admet-291	332	20	(	(	PUNCT
admet-291	332	21	cimap	cimap	NOUN
admet-291	332	22	-	-	PUNCT
admet-291	332	23	csir	csir	NOUN
admet-291	332	24	)	)	PUNCT
admet-291	332	25	,	,	PUNCT
admet-291	332	26	lucknow	lucknow	PROPN
admet-291	332	27	.	.	PUNCT
admet-291	332	28	35	35	NUM
admet-291	332	29	36	36	NUM
admet-291	332	30	references	reference	NOUN
admet-291	332	31	37	37	NUM
admet-291	332	32	[	[	X
admet-291	332	33	1	1	NUM
admet-291	332	34	]	]	PUNCT
admet-291	332	35	a.	a.	NOUN
admet-291	332	36	jemal	jemal	PROPN
admet-291	332	37	,	,	PUNCT
admet-291	332	38	r.	r.	PROPN
admet-291	332	39	siegel	siegel	PROPN
admet-291	332	40	,	,	PUNCT
admet-291	332	41	j.	j.	PROPN
admet-291	332	42	xu	xu	PROPN
admet-291	332	43	,	,	PUNCT
admet-291	332	44	e.	e.	PROPN
admet-291	332	45	ward	ward	PROPN
admet-291	332	46	.	.	PUNCT
admet-291	333	1	ca	can	AUX
admet-291	333	2	:	:	PUNCT
admet-291	333	3	a	a	DET
admet-291	333	4	cancer	cancer	NOUN
admet-291	333	5	journal	journal	NOUN
admet-291	333	6	for	for	ADP
admet-291	333	7	clinicians	clinician	NOUN
admet-291	333	8	60	60	NUM
admet-291	333	9	(	(	PUNCT
admet-291	333	10	2010	2010	NUM
admet-291	333	11	)	)	PUNCT
admet-291	333	12	277	277	NUM
admet-291	333	13	-	-	SYM
admet-291	333	14	300	300	NUM
admet-291	333	15	.	.	PUNCT
admet-291	334	1	38	38	NUM
admet-291	335	1	[	[	SYM
admet-291	335	2	2	2	NUM
admet-291	335	3	]	]	X
admet-291	335	4	b.b	b.b	PROPN
admet-291	335	5	.	.	PROPN
admet-291	335	6	aggarwal	aggarwal	PROPN
admet-291	335	7	,	,	PUNCT
admet-291	335	8	d.	d.	PROPN
admet-291	335	9	danda	danda	PROPN
admet-291	335	10	,	,	PUNCT
admet-291	335	11	s.	s.	PROPN
admet-291	335	12	gupta	gupta	PROPN
admet-291	335	13	,	,	PUNCT
admet-291	335	14	p.	p.	PROPN
admet-291	335	15	gehlot	gehlot	NOUN
admet-291	335	16	.	.	PUNCT
admet-291	336	1	biochemical	biochemical	ADJ
admet-291	336	2	pharmacology	pharmacology	NOUN
admet-291	336	3	78	78	NUM
admet-291	336	4	(	(	PUNCT
admet-291	336	5	2009	2009	NUM
admet-291	336	6	)	)	PUNCT
admet-291	336	7	1083–1094	1083–1094	NUM
admet-291	336	8	.	.	PUNCT
admet-291	337	1	39	39	NUM
admet-291	338	1	[	[	X
admet-291	338	2	3	3	X
admet-291	338	3	]	]	X
admet-291	338	4	s.	s.	PROPN
admet-291	338	5	coseri	coseri	PROPN
admet-291	338	6	,	,	PUNCT
admet-291	338	7	mini	mini	NOUN
admet-291	338	8	-	-	NOUN
admet-291	338	9	reviews	review	NOUN
admet-291	338	10	in	in	ADP
admet-291	338	11	medicinal	medicinal	ADJ
admet-291	338	12	chemistry	chemistry	NOUN
admet-291	338	13	9	9	NUM
admet-291	338	14	(	(	PUNCT
admet-291	338	15	2009	2009	NUM
admet-291	338	16	)	)	PUNCT
admet-291	338	17	560	560	NUM
admet-291	338	18	-	-	SYM
admet-291	338	19	571	571	NUM
admet-291	338	20	.	.	PUNCT
admet-291	338	21	40	40	NUM
admet-291	339	1	[	[	SYM
admet-291	339	2	4	4	NUM
admet-291	339	3	]	]	X
admet-291	339	4	d.j	d.j	PROPN
admet-291	339	5	.	.	PROPN
admet-291	339	6	newman	newman	PROPN
admet-291	339	7	,	,	PUNCT
admet-291	339	8	journal	journal	NOUN
admet-291	339	9	of	of	ADP
admet-291	339	10	medicinal	medicinal	ADJ
admet-291	339	11	chemistry	chemistry	NOUN
admet-291	339	12	51	51	NUM
admet-291	339	13	(	(	PUNCT
admet-291	339	14	2008	2008	NUM
admet-291	339	15	)	)	PUNCT
admet-291	339	16	2589	2589	NUM
admet-291	339	17	-	-	SYM
admet-291	339	18	2599	2599	NUM
admet-291	339	19	.	.	PUNCT
admet-291	340	1	41	41	NUM
admet-291	341	1	[	[	X
admet-291	341	2	5	5	NUM
admet-291	341	3	]	]	X
admet-291	341	4	d.j	d.j	PROPN
admet-291	341	5	.	.	PROPN
admet-291	341	6	newman	newman	PROPN
admet-291	341	7	,	,	PUNCT
admet-291	341	8	g.	g.	PROPN
admet-291	341	9	m.	m.	PROPN
admet-291	341	10	cragg	cragg	PROPN
admet-291	341	11	,	,	PUNCT
admet-291	341	12	journal	journal	NOUN
admet-291	341	13	of	of	ADP
admet-291	341	14	natural	natural	ADJ
admet-291	341	15	products	product	NOUN
admet-291	341	16	75	75	NUM
admet-291	341	17	(	(	PUNCT
admet-291	341	18	2012	2012	NUM
admet-291	341	19	)	)	PUNCT
admet-291	341	20	311	311	NUM
admet-291	341	21	-	-	SYM
admet-291	341	22	335	335	NUM
admet-291	341	23	.	.	PUNCT
admet-291	341	24	42	42	NUM
admet-291	342	1	[	[	SYM
admet-291	342	2	6	6	NUM
admet-291	342	3	]	]	PUNCT
admet-291	342	4	m.	m.	NOUN
admet-291	342	5	s.	s.	PROPN
admet-291	342	6	kinch	kinch	PROPN
admet-291	342	7	,	,	PUNCT
admet-291	342	8	a.	a.	PROPN
admet-291	342	9	haynesworth	haynesworth	PROPN
admet-291	342	10	,	,	PUNCT
admet-291	342	11	s.l	s.l	PROPN
admet-291	342	12	.	.	PROPN
admet-291	342	13	kinch	kinch	PROPN
admet-291	342	14	,	,	PUNCT
admet-291	342	15	d.	d.	PROPN
admet-291	342	16	hoyer	hoyer	PROPN
admet-291	342	17	,	,	PUNCT
admet-291	342	18	drug	drug	NOUN
admet-291	342	19	discovery	discovery	NOUN
admet-291	342	20	today	today	NOUN
admet-291	342	21	19	19	NUM
admet-291	342	22	(	(	PUNCT
admet-291	342	23	2014	2014	NUM
admet-291	342	24	)	)	PUNCT
admet-291	342	25	1033–1039	1033–1039	NUM
admet-291	342	26	.	.	PUNCT
admet-291	343	1	43	43	NUM
admet-291	343	2	deepika	deepika	PROPN
admet-291	343	3	singh	singh	PROPN
admet-291	343	4	admet	admet	PROPN
admet-291	343	5	&	&	CCONJ
admet-291	343	6	dmpk	dmpk	PROPN
admet-291	343	7	4(2	4(2	NUM
admet-291	343	8	)	)	PUNCT
admet-291	343	9	(	(	PUNCT
admet-291	343	10	2016	2016	NUM
admet-291	343	11	)	)	PUNCT
admet-291	343	12	98	98	NUM
admet-291	343	13	-	-	SYM
admet-291	343	14	113	113	NUM
admet-291	343	15	doi	doi	NOUN
admet-291	343	16	:	:	PUNCT
admet-291	343	17	10.5599	10.5599	NUM
admet-291	343	18	/	/	SYM
admet-291	343	19	admet.4.2.291	admet.4.2.291	PROPN
admet-291	343	20	113	113	NUM
admet-291	343	21	[	[	X
admet-291	343	22	7	7	NUM
admet-291	343	23	]	]	X
admet-291	343	24	c.	c.	PROPN
admet-291	343	25	d.	d.	PROPN
admet-291	343	26	bradley	bradley	PROPN
admet-291	343	27	,	,	PUNCT
admet-291	343	28	o.	o.	PROPN
admet-291	343	29	bjӧrn	bjӧrn	PROPN
admet-291	343	30	,	,	PUNCT
admet-291	343	31	g.	g.	PROPN
admet-291	343	32	fabrizio	fabrizio	PROPN
admet-291	343	33	,	,	PUNCT
admet-291	343	34	k.	k.	PROPN
admet-291	343	35	jan	jan	PROPN
admet-291	343	36	,	,	PUNCT
admet-291	343	37	chemistry	chemistry	NOUN
admet-291	343	38	&	&	CCONJ
admet-291	343	39	biology	biology	NOUN
admet-291	343	40	21	21	NUM
admet-291	343	41	(	(	PUNCT
admet-291	343	42	2014	2014	NUM
admet-291	343	43	)	)	PUNCT
admet-291	343	44	1115	1115	NUM
admet-291	343	45	–	–	PUNCT
admet-291	343	46	1142	1142	NUM
admet-291	343	47	.	.	PUNCT
admet-291	343	48	44	44	NUM
admet-291	344	1	[	[	SYM
admet-291	344	2	8	8	NUM
admet-291	344	3	]	]	X
admet-291	344	4	n.a	n.a	PROPN
admet-291	344	5	.	.	PROPN
admet-291	344	6	meanwell	meanwell	PROPN
admet-291	344	7	,	,	PUNCT
admet-291	344	8	chemical	chemical	NOUN
admet-291	344	9	research	research	NOUN
admet-291	344	10	in	in	ADP
admet-291	344	11	toxicology	toxicology	NOUN
admet-291	344	12	24	24	NUM
admet-291	344	13	(	(	PUNCT
admet-291	344	14	2011	2011	NUM
admet-291	344	15	)	)	PUNCT
admet-291	344	16	1420–1456	1420–1456	NUM
admet-291	344	17	.	.	PUNCT
admet-291	345	1	45	45	NUM
admet-291	346	1	[	[	SYM
admet-291	346	2	9	9	NUM
admet-291	346	3	]	]	PUNCT
admet-291	346	4	p.	p.	NOUN
admet-291	346	5	barton	barton	PROPN
admet-291	346	6	,	,	PUNCT
admet-291	346	7	r.j	r.j	PROPN
admet-291	346	8	.	.	PROPN
admet-291	346	9	riley	riley	PROPN
admet-291	346	10	,	,	PUNCT
admet-291	346	11	drug	drug	NOUN
admet-291	346	12	discovery	discovery	NOUN
admet-291	346	13	today	today	NOUN
admet-291	346	14	21	21	NUM
admet-291	346	15	(	(	PUNCT
admet-291	346	16	2016	2016	NUM
admet-291	346	17	)	)	PUNCT
admet-291	346	18	72	72	NUM
admet-291	346	19	-	-	SYM
admet-291	346	20	81	81	NUM
admet-291	346	21	.	.	PUNCT
admet-291	346	22	46	46	NUM
admet-291	347	1	[	[	X
admet-291	347	2	10	10	NUM
admet-291	347	3	]	]	X
admet-291	347	4	m.p	m.p	PROPN
admet-291	347	5	.	.	PROPN
admet-291	347	6	gleeson	gleeson	PROPN
admet-291	347	7	,	,	PUNCT
admet-291	347	8	journal	journal	NOUN
admet-291	347	9	of	of	ADP
admet-291	347	10	medicinal	medicinal	ADJ
admet-291	347	11	chemistry	chemistry	NOUN
admet-291	347	12	51	51	NUM
admet-291	347	13	(	(	PUNCT
admet-291	347	14	2008	2008	NUM
admet-291	347	15	)	)	PUNCT
admet-291	347	16	817–834	817–834	NUM
admet-291	347	17	.	.	PUNCT
admet-291	348	1	47	47	NUM
admet-291	349	1	[	[	SYM
admet-291	349	2	11	11	NUM
admet-291	349	3	]	]	X
admet-291	349	4	c.a	c.a	PROPN
admet-291	349	5	.	.	PROPN
admet-291	349	6	lipinski	lipinski	PROPN
admet-291	349	7	,	,	PUNCT
admet-291	349	8	f.	f.	PROPN
admet-291	349	9	lombardo	lombardo	PROPN
admet-291	349	10	,	,	PUNCT
admet-291	349	11	b.w	b.w	PROPN
admet-291	349	12	.	.	PROPN
admet-291	349	13	dominy	dominy	PROPN
admet-291	349	14	,	,	PUNCT
admet-291	349	15	p.j	p.j	PROPN
admet-291	349	16	.	.	PROPN
admet-291	349	17	feeney	feeney	PROPN
admet-291	349	18	,	,	PUNCT
admet-291	349	19	advanced	advanced	ADJ
admet-291	349	20	drug	drug	NOUN
admet-291	349	21	delivery	delivery	NOUN
admet-291	349	22	reviews	review	VERB
admet-291	349	23	23	23	NUM
admet-291	349	24	(	(	PUNCT
admet-291	349	25	1997	1997	NUM
admet-291	349	26	)	)	PUNCT
admet-291	350	1	3–48	3–48	PROPN
admet-291	350	2	25	25	NUM
admet-291	350	3	.	.	PUNCT
admet-291	350	4	49	49	NUM
admet-291	351	1	[	[	X
admet-291	351	2	12	12	NUM
admet-291	351	3	]	]	X
admet-291	351	4	d.f	d.f	PROPN
admet-291	351	5	.	.	PROPN
admet-291	351	6	veber	veber	PROPN
admet-291	351	7	,	,	PUNCT
admet-291	351	8	s.r	s.r	PROPN
admet-291	351	9	.	.	PROPN
admet-291	351	10	johnson	johnson	PROPN
admet-291	351	11	,	,	PUNCT
admet-291	351	12	h.y	h.y	PROPN
admet-291	351	13	.	.	PROPN
admet-291	351	14	cheng	cheng	PROPN
admet-291	351	15	,	,	PUNCT
admet-291	351	16	b.r	b.r	PROPN
admet-291	351	17	.	.	PROPN
admet-291	351	18	smith	smith	PROPN
admet-291	351	19	,	,	PUNCT
admet-291	351	20	k.w	k.w	PROPN
admet-291	351	21	.	.	PROPN
admet-291	351	22	ward	ward	PROPN
admet-291	351	23	,	,	PUNCT
admet-291	351	24	k.d	k.d	PROPN
admet-291	351	25	.	.	PROPN
admet-291	351	26	kopple	kopple	PROPN
admet-291	351	27	,	,	PUNCT
admet-291	351	28	journal	journal	NOUN
admet-291	351	29	of	of	ADP
admet-291	351	30	medicinal	medicinal	ADJ
admet-291	351	31	50	50	NUM
admet-291	351	32	chemistry	chemistry	NOUN
admet-291	351	33	45	45	NUM
admet-291	351	34	(	(	PUNCT
admet-291	351	35	2002	2002	NUM
admet-291	351	36	)	)	PUNCT
admet-291	351	37	2615	2615	NUM
admet-291	351	38	-	-	SYM
admet-291	351	39	2623	2623	NUM
admet-291	351	40	.	.	PUNCT
admet-291	352	1	51	51	NUM
admet-291	353	1	[	[	SYM
admet-291	353	2	13	13	NUM
admet-291	353	3	]	]	X
admet-291	353	4	a.k	a.k	PROPN
admet-291	353	5	.	.	PROPN
admet-291	353	6	ghose	ghose	PROPN
admet-291	353	7	,	,	PUNCT
admet-291	353	8	v.n	v.n	PROPN
admet-291	353	9	.	.	PROPN
admet-291	353	10	viswanadhan	viswanadhan	PROPN
admet-291	353	11	,	,	PUNCT
admet-291	353	12	j.j	j.j	PROPN
admet-291	353	13	.	.	PROPN
admet-291	353	14	wendoloski	wendoloski	PROPN
admet-291	353	15	journal	journal	PROPN
admet-291	353	16	of	of	ADP
admet-291	353	17	computational	computational	ADJ
admet-291	353	18	chemistry	chemistry	NOUN
admet-291	353	19	1	1	NUM
admet-291	353	20	(	(	PUNCT
admet-291	353	21	1999	1999	NUM
admet-291	353	22	)	)	PUNCT
admet-291	353	23	55	55	NUM
admet-291	353	24	-	-	SYM
admet-291	353	25	68	68	NUM
admet-291	353	26	.	.	PUNCT
admet-291	353	27	52	52	NUM
admet-291	354	1	[	[	X
admet-291	354	2	14	14	NUM
admet-291	354	3	]	]	PUNCT
admet-291	354	4	p.	p.	PROPN
admet-291	354	5	d.	d.	PROPN
admet-291	354	6	leeson	leeson	PROPN
admet-291	354	7	,	,	PUNCT
admet-291	354	8	advanced	advanced	ADJ
admet-291	354	9	drug	drug	NOUN
admet-291	354	10	delivery	delivery	NOUN
admet-291	354	11	reviews	review	VERB
admet-291	354	12	101	101	NUM
admet-291	354	13	(	(	PUNCT
admet-291	354	14	2016	2016	NUM
admet-291	354	15	)	)	PUNCT
admet-291	354	16	22	22	NUM
admet-291	354	17	-	-	SYM
admet-291	354	18	33	33	NUM
admet-291	354	19	.	.	PUNCT
admet-291	355	1	53	53	NUM
admet-291	356	1	[	[	SYM
admet-291	356	2	15	15	NUM
admet-291	356	3	]	]	X
admet-291	356	4	e.c.a	e.c.a	NOUN
admet-291	356	5	cornelis	cornelis	PROPN
admet-291	356	6	.	.	PUNCT
admet-291	357	1	hop	hop	PROPN
admet-291	357	2	attrition	attrition	NOUN
admet-291	357	3	in	in	ADP
admet-291	357	4	the	the	DET
admet-291	357	5	pharmaceutical	pharmaceutical	ADJ
admet-291	357	6	industry	industry	NOUN
admet-291	357	7	:	:	PUNCT
admet-291	357	8	reasons	reason	NOUN
admet-291	357	9	,	,	PUNCT
admet-291	357	10	implications	implication	NOUN
admet-291	357	11	,	,	PUNCT
admet-291	357	12	and	and	CCONJ
admet-291	357	13	pathways	pathway	NOUN
admet-291	357	14	54	54	NUM
admet-291	357	15	forward	forward	ADV
admet-291	357	16	,	,	PUNCT
admet-291	357	17	ed	ed	NOUN
admet-291	357	18	.	.	PUNCT
admet-291	357	19	a.	a.	PROPN
admet-291	357	20	alex	alex	PROPN
admet-291	357	21	,	,	PUNCT
admet-291	357	22	c.j	c.j	PROPN
admet-291	357	23	.	.	PROPN
admet-291	357	24	harris	harris	PROPN
admet-291	357	25	,	,	PUNCT
admet-291	357	26	d.a	d.a	PROPN
admet-291	357	27	.	.	PROPN
admet-291	357	28	smith	smith	PROPN
admet-291	357	29	.	.	PUNCT
admet-291	358	1	(	(	PUNCT
admet-291	358	2	2016	2016	NUM
admet-291	358	3	)	)	PUNCT
admet-291	358	4	john	john	PROPN
admet-291	358	5	wiley	wiley	PROPN
admet-291	358	6	&	&	CCONJ
admet-291	358	7	sons	sons	PROPN
admet-291	358	8	,	,	PUNCT
admet-291	358	9	inc	inc	PROPN
admet-291	358	10	.	.	PROPN
admet-291	358	11	55	55	NUM
admet-291	359	1	[	[	X
admet-291	359	2	16	16	NUM
admet-291	359	3	]	]	X
admet-291	359	4	d.c	d.c	PROPN
admet-291	359	5	.	.	PROPN
admet-291	359	6	swinney	swinney	PROPN
admet-291	359	7	,	,	PUNCT
admet-291	359	8	j.	j.	PROPN
admet-291	359	9	anthony	anthony	PROPN
admet-291	359	10	,	,	PUNCT
admet-291	359	11	nature	nature	NOUN
admet-291	359	12	reviews	review	VERB
admet-291	359	13	drug	drug	NOUN
admet-291	359	14	discovery	discovery	NOUN
admet-291	359	15	10	10	NUM
admet-291	359	16	(	(	PUNCT
admet-291	359	17	2011	2011	NUM
admet-291	359	18	)	)	PUNCT
admet-291	359	19	507–519	507–519	NUM
admet-291	359	20	.	.	PUNCT
admet-291	360	1	56	56	NUM
admet-291	360	2	[	[	SYM
admet-291	360	3	17	17	NUM
admet-291	360	4	]	]	X
admet-291	360	5	k.k	k.k	PROPN
admet-291	360	6	.	.	PROPN
admet-291	360	7	dholwani	dholwani	PROPN
admet-291	360	8	,	,	PUNCT
admet-291	360	9	a.k	a.k	PROPN
admet-291	360	10	.	.	PROPN
admet-291	360	11	saluja	saluja	PROPN
admet-291	360	12	,	,	PUNCT
admet-291	360	13	a.r	a.r	PROPN
admet-291	360	14	.	.	PROPN
admet-291	360	15	gupta	gupta	PROPN
admet-291	360	16	,	,	PUNCT
admet-291	360	17	d.r	d.r	PROPN
admet-291	360	18	.	.	PROPN
admet-291	360	19	shah	shah	PROPN
admet-291	360	20	,	,	PUNCT
admet-291	360	21	indian	indian	PROPN
admet-291	360	22	journal	journal	NOUN
admet-291	360	23	of	of	ADP
admet-291	360	24	pharmacology	pharmacology	NOUN
admet-291	360	25	40	40	NUM
admet-291	360	26	(	(	PUNCT
admet-291	360	27	2008	2008	NUM
admet-291	360	28	)	)	PUNCT
admet-291	360	29	49–58	49–58	NUM
admet-291	360	30	.	.	PUNCT
admet-291	361	1	57	57	NUM
admet-291	362	1	[	[	SYM
admet-291	362	2	18	18	NUM
admet-291	362	3	]	]	PUNCT
admet-291	362	4	a.	a.	NOUN
admet-291	362	5	bhanot	bhanot	PROPN
admet-291	362	6	,	,	PUNCT
admet-291	362	7	r.	r.	PROPN
admet-291	362	8	sharma	sharma	PROPN
admet-291	362	9	,	,	PUNCT
admet-291	362	10	m.	m.	NOUN
admet-291	362	11	n.	n.	PROPN
admet-291	362	12	noolvi	noolvi	PROPN
admet-291	362	13	,	,	PUNCT
admet-291	362	14	international	international	ADJ
admet-291	362	15	journal	journal	NOUN
admet-291	362	16	of	of	ADP
admet-291	362	17	phytomedicine	phytomedicine	NOUN
admet-291	362	18	3	3	NUM
admet-291	362	19	(	(	PUNCT
admet-291	362	20	2011	2011	NUM
admet-291	362	21	)	)	PUNCT
admet-291	362	22	9	9	NUM
admet-291	362	23	-	-	SYM
admet-291	362	24	26	26	NUM
admet-291	362	25	.	.	PUNCT
admet-291	362	26	58	58	NUM
admet-291	363	1	[	[	X
admet-291	363	2	19	19	NUM
admet-291	363	3	]	]	X
admet-291	363	4	t.	t.	NOUN
admet-291	363	5	sander	sander	PROPN
admet-291	363	6	,	,	PUNCT
admet-291	363	7	j.	j.	PROPN
admet-291	363	8	freyss	freyss	PROPN
admet-291	363	9	,	,	PUNCT
admet-291	363	10	m.v	m.v	PROPN
admet-291	363	11	.	.	PROPN
admet-291	363	12	korff	korff	PROPN
admet-291	363	13	,	,	PUNCT
admet-291	363	14	c.	c.	PROPN
admet-291	363	15	rufener	rufener	PROPN
admet-291	363	16	,	,	PUNCT
admet-291	363	17	journal	journal	NOUN
admet-291	363	18	of	of	ADP
admet-291	363	19	chemical	chemical	ADJ
admet-291	363	20	information	information	NOUN
admet-291	363	21	and	and	CCONJ
admet-291	363	22	modeling	modeling	NOUN
admet-291	363	23	,	,	PUNCT
admet-291	363	24	55	55	NUM
admet-291	363	25	(	(	PUNCT
admet-291	363	26	2015	2015	NUM
admet-291	363	27	)	)	PUNCT
admet-291	363	28	59	59	NUM
admet-291	363	29	460–473	460–473	NUM
admet-291	363	30	.	.	PUNCT
admet-291	364	1	60	60	NUM
admet-291	365	1	[	[	SYM
admet-291	365	2	20	20	NUM
admet-291	365	3	]	]	X
admet-291	365	4	m.d	m.d	PROPN
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admet-291	365	7	,	,	PUNCT
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admet-291	365	9	.	.	PROPN
admet-291	365	10	curtis	curtis	PROPN
admet-291	365	11	,	,	PUNCT
admet-291	365	12	d.c	d.c	PROPN
admet-291	365	13	.	.	PROPN
admet-291	365	14	lonie	lonie	PROPN
admet-291	365	15	,	,	PUNCT
admet-291	365	16	t.	t.	PROPN
admet-291	365	17	vandermeersch	vandermeersch	PROPN
admet-291	365	18	,	,	PUNCT
admet-291	365	19	e.	e.	PROPN
admet-291	365	20	zurek	zurek	PROPN
admet-291	365	21	,	,	PUNCT
admet-291	365	22	g.r	g.r	PROPN
admet-291	365	23	.	.	PROPN
admet-291	365	24	hutchison	hutchison	PROPN
admet-291	365	25	,	,	PUNCT
admet-291	365	26	journal	journal	NOUN
admet-291	365	27	of	of	ADP
admet-291	365	28	61	61	NUM
admet-291	365	29	cheminformatics	cheminformatic	NOUN
admet-291	365	30	4	4	NUM
admet-291	365	31	(	(	PUNCT
admet-291	365	32	2012	2012	NUM
admet-291	365	33	)	)	PUNCT
admet-291	365	34	1	1	NUM
admet-291	365	35	-	-	SYM
admet-291	365	36	17	17	NUM
admet-291	365	37	.	.	PUNCT
admet-291	366	1	62	62	NUM
admet-291	367	1	[	[	X
admet-291	367	2	21	21	NUM
admet-291	367	3	]	]	X
admet-291	367	4	e.v.p	e.v.p	PROPN
admet-291	367	5	.	.	PUNCT
admet-291	367	6	douglas	douglas	PROPN
admet-291	367	7	,	,	PUNCT
admet-291	367	8	t.l	t.l	PROPN
admet-291	367	9	.	.	PROPN
admet-291	367	10	blundell	blundell	PROPN
admet-291	367	11	,	,	PUNCT
admet-291	367	12	d.b	d.b	PROPN
admet-291	367	13	.	.	PROPN
admet-291	367	14	ascher	ascher	PROPN
admet-291	367	15	,	,	PUNCT
admet-291	367	16	journal	journal	NOUN
admet-291	367	17	of	of	ADP
admet-291	367	18	medicinal	medicinal	ADJ
admet-291	367	19	chemistry	chemistry	NOUN
admet-291	367	20	58	58	NUM
admet-291	367	21	(	(	PUNCT
admet-291	367	22	2015	2015	NUM
admet-291	367	23	)	)	PUNCT
admet-291	367	24	4066–4072	4066–4072	NOUN
admet-291	367	25	.	.	PUNCT
admet-291	368	1	63	63	NUM
admet-291	369	1	[	[	SYM
admet-291	369	2	22	22	NUM
admet-291	369	3	]	]	PUNCT
admet-291	369	4	m.	m.	NOUN
admet-291	369	5	j.	j.	PROPN
admet-291	369	6	waring	waring	PROPN
admet-291	369	7	,	,	PUNCT
admet-291	369	8	bioorganic	bioorganic	PROPN
admet-291	369	9	&	&	CCONJ
admet-291	369	10	medicinal	medicinal	ADJ
admet-291	369	11	chemistry	chemistry	NOUN
admet-291	369	12	letters	letter	NOUN
admet-291	369	13	,	,	PUNCT
admet-291	369	14	19	19	NUM
admet-291	369	15	(	(	PUNCT
admet-291	369	16	2009	2009	NUM
admet-291	369	17	)	)	PUNCT
admet-291	369	18	2844–2851	2844–2851	NUM
admet-291	369	19	64	64	NUM
admet-291	369	20	[	[	X
admet-291	369	21	23	23	NUM
admet-291	369	22	]	]	X
admet-291	369	23	d.a	d.a	PROPN
admet-291	369	24	.	.	PROPN
admet-291	369	25	smith	smith	PROPN
admet-291	369	26	,	,	PUNCT
admet-291	369	27	l.	l.	PROPN
admet-291	369	28	di	di	PROPN
admet-291	369	29	,	,	PUNCT
admet-291	369	30	e.h	e.h	PROPN
admet-291	369	31	.	.	PROPN
admet-291	369	32	kerns	kerns	PROPN
admet-291	369	33	,	,	PUNCT
admet-291	369	34	nature	nature	NOUN
admet-291	369	35	reviews	review	VERB
admet-291	369	36	drug	drug	NOUN
admet-291	369	37	discovery	discovery	NOUN
admet-291	369	38	9	9	NUM
admet-291	369	39	(	(	PUNCT
admet-291	369	40	2010	2010	NUM
admet-291	369	41	)	)	PUNCT
admet-291	369	42	929	929	NUM
admet-291	369	43	-	-	SYM
admet-291	369	44	939	939	NUM
admet-291	369	45	.	.	PUNCT
admet-291	370	1	65	65	NUM
admet-291	371	1	[	[	X
admet-291	371	2	24	24	NUM
admet-291	371	3	]	]	X
admet-291	371	4	d.a	d.a	PROPN
admet-291	371	5	.	.	PROPN
admet-291	371	6	smith	smith	PROPN
admet-291	371	7	,	,	PUNCT
admet-291	371	8	h.	h.	PROPN
admet-291	371	9	van	van	PROPN
admet-291	371	10	de	de	PROPN
admet-291	371	11	waterbeemd	waterbeemd	PROPN
admet-291	371	12	,	,	PUNCT
admet-291	371	13	d.k	d.k	PROPN
admet-291	371	14	.	.	PROPN
admet-291	371	15	walker	walker	PROPN
admet-291	371	16	,	,	PUNCT
admet-291	371	17	(	(	PUNCT
admet-291	371	18	2001	2001	NUM
admet-291	371	19	)	)	PUNCT
admet-291	371	20	pharmacokinetics	pharmacokinetic	NOUN
admet-291	371	21	and	and	CCONJ
admet-291	371	22	metabolism	metabolism	NOUN
admet-291	371	23	in	in	ADP
admet-291	371	24	drug	drug	NOUN
admet-291	371	25	66	66	NUM
admet-291	371	26	design	design	NOUN
admet-291	371	27	.	.	PUNCT
admet-291	372	1	wiley	wiley	PROPN
admet-291	372	2	–	–	PUNCT
admet-291	372	3	vch	vch	PROPN
admet-291	372	4	,	,	PUNCT
admet-291	372	5	weinheim	weinheim	PROPN
admet-291	372	6	,	,	PUNCT
admet-291	372	7	germany	germany	PROPN
admet-291	372	8	.	.	PUNCT
admet-291	373	1	67	67	NUM
admet-291	374	1	[	[	X
admet-291	374	2	25	25	NUM
admet-291	374	3	]	]	PUNCT
admet-291	374	4	k.	k.	PROPN
admet-291	374	5	a.	a.	PROPN
admet-291	374	6	houck	houck	PROPN
admet-291	374	7	,	,	PUNCT
admet-291	374	8	r.j	r.j	PROPN
admet-291	374	9	.	.	PROPN
admet-291	374	10	kavlock	kavlock	NOUN
admet-291	374	11	,	,	PUNCT
admet-291	374	12	toxicology	toxicology	NOUN
admet-291	374	13	and	and	CCONJ
admet-291	374	14	applied	apply	VERB
admet-291	374	15	pharmacology	pharmacology	NOUN
admet-291	374	16	227	227	NUM
admet-291	374	17	(	(	PUNCT
admet-291	374	18	2008	2008	NUM
admet-291	374	19	)	)	PUNCT
admet-291	374	20	163–178	163–178	NUM
admet-291	374	21	.	.	PUNCT
admet-291	375	1	68	68	NUM
admet-291	376	1	[	[	SYM
admet-291	376	2	26	26	NUM
admet-291	376	3	]	]	X
admet-291	376	4	v.p	v.p	PROPN
admet-291	376	5	.	.	PROPN
admet-291	376	6	miller	miller	PROPN
admet-291	376	7	,	,	PUNCT
admet-291	376	8	d.m	d.m	PROPN
admet-291	376	9	.	.	PUNCT
admet-291	376	10	stresser	stresser	PROPN
admet-291	376	11	,	,	PUNCT
admet-291	376	12	a.	a.	NOUN
admet-291	376	13	p.	p.	PROPN
admet-291	376	14	blanchard	blanchard	PROPN
admet-291	376	15	,	,	PUNCT
admet-291	376	16	s.	s.	PROPN
admet-291	376	17	turner	turner	PROPN
admet-291	376	18	,	,	PUNCT
admet-291	376	19	c.	c.	PROPN
admet-291	376	20	l.	l.	PROPN
admet-291	376	21	crespi	crespi	PROPN
admet-291	376	22	,	,	PUNCT
admet-291	376	23	annals	annal	NOUN
admet-291	376	24	of	of	ADP
admet-291	376	25	the	the	DET
admet-291	376	26	new	new	PROPN
admet-291	376	27	york	york	PROPN
admet-291	376	28	academy	academy	PROPN
admet-291	376	29	of	of	ADP
admet-291	376	30	69	69	NUM
admet-291	376	31	sciences	science	NOUN
admet-291	376	32	919	919	NUM
admet-291	376	33	(	(	PUNCT
admet-291	376	34	2000	2000	NUM
admet-291	376	35	)	)	PUNCT
admet-291	377	1	26–32	26–32	NUM
admet-291	377	2	.	.	PUNCT
admet-291	377	3	70	70	NUM
admet-291	378	1	[	[	SYM
admet-291	378	2	27	27	NUM
admet-291	378	3	]	]	PUNCT
admet-291	378	4	m.	m.	NOUN
admet-291	378	5	deacon	deacon	PROPN
admet-291	378	6	,	,	PUNCT
admet-291	378	7	d.	d.	PROPN
admet-291	378	8	singleton	singleton	PROPN
admet-291	378	9	,	,	PUNCT
admet-291	378	10	n.	n.	PROPN
admet-291	378	11	szalkai	szalkai	PROPN
admet-291	378	12	,	,	PUNCT
admet-291	378	13	r.	r.	PROPN
admet-291	378	14	pasieczny	pasieczny	PROPN
admet-291	378	15	,	,	PUNCT
admet-291	378	16	c.	c.	NOUN
admet-291	378	17	peacock	peacock	NOUN
admet-291	378	18	,	,	PUNCT
admet-291	378	19	d.	d.	PROPN
admet-291	378	20	price	price	PROPN
admet-291	378	21	,	,	PUNCT
admet-291	378	22	j.	j.	PROPN
admet-291	378	23	boyd	boyd	PROPN
admet-291	378	24	,	,	PUNCT
admet-291	378	25	h.	h.	PROPN
admet-291	378	26	boyd	boyd	PROPN
admet-291	378	27	,	,	PUNCT
admet-291	378	28	j.v	j.v	PROPN
admet-291	378	29	.	.	PUNCT
admet-291	379	1	steidl-71	steidl-71	PROPN
admet-291	379	2	nichols	nichols	PROPN
admet-291	379	3	,	,	PUNCT
admet-291	379	4	c.	c.	PROPN
admet-291	379	5	williams	williams	PROPN
admet-291	379	6	,	,	PUNCT
admet-291	379	7	journal	journal	NOUN
admet-291	379	8	of	of	ADP
admet-291	379	9	pharmacological	pharmacological	ADJ
admet-291	379	10	and	and	CCONJ
admet-291	379	11	toxicological	toxicological	ADJ
admet-291	379	12	methods	method	NOUN
admet-291	379	13	55	55	NUM
admet-291	379	14	(	(	PUNCT
admet-291	379	15	2007	2007	NUM
admet-291	379	16	)	)	PUNCT
admet-291	379	17	238–247	238–247	NUM
admet-291	379	18	.	.	PUNCT
admet-291	379	19	72	72	NUM
admet-291	380	1	[	[	X
admet-291	380	2	28	28	NUM
admet-291	380	3	]	]	X
admet-291	380	4	e.h	e.h	PROPN
admet-291	380	5	.	.	PROPN
admet-291	380	6	kerns	kerns	PROPN
admet-291	380	7	,	,	PUNCT
admet-291	380	8	l.	l.	PROPN
admet-291	380	9	di	di	PROPN
admet-291	380	10	,	,	PUNCT
admet-291	380	11	(	(	PUNCT
admet-291	380	12	2008	2008	NUM
admet-291	380	13	)	)	PUNCT
admet-291	380	14	.	.	PUNCT
admet-291	381	1	drug	drug	NOUN
admet-291	381	2	-	-	PUNCT
admet-291	381	3	like	like	ADJ
admet-291	381	4	properties	property	NOUN
admet-291	381	5	:	:	PUNCT
admet-291	381	6	concepts	concept	NOUN
admet-291	381	7	,	,	PUNCT
admet-291	381	8	structure	structure	NOUN
admet-291	381	9	design	design	NOUN
admet-291	381	10	and	and	CCONJ
admet-291	381	11	methods	method	NOUN
admet-291	381	12	:	:	PUNCT
admet-291	381	13	from	from	ADP
admet-291	381	14	adme	adme	NOUN
admet-291	381	15	73	73	NUM
admet-291	381	16	to	to	ADP
admet-291	381	17	toxicity	toxicity	NOUN
admet-291	381	18	optimization	optimization	NOUN
admet-291	381	19	.	.	PUNCT
admet-291	382	1	(	(	PUNCT
admet-291	382	2	amsterdam	amsterdam	PROPN
admet-291	382	3	,	,	PUNCT
admet-291	382	4	boston	boston	PROPN
admet-291	382	5	:	:	PUNCT
admet-291	382	6	academic	academic	ADJ
admet-291	382	7	press	press	NOUN
admet-291	382	8	)	)	PUNCT
admet-291	382	9	.	.	PUNCT
admet-291	383	1	74	74	NUM
admet-291	384	1	[	[	SYM
admet-291	384	2	29	29	NUM
admet-291	384	3	]	]	SYM
admet-291	384	4	c.m	c.m	PROPN
admet-291	384	5	.	.	PROPN
admet-291	384	6	hosey	hosey	PROPN
admet-291	384	7	,	,	PUNCT
admet-291	384	8	l.z	l.z	PROPN
admet-291	384	9	.	.	PROPN
admet-291	384	10	benet	benet	PROPN
admet-291	384	11	,	,	PUNCT
admet-291	384	12	molecular	molecular	ADJ
admet-291	384	13	pharmaceutics	pharmaceutic	NOUN
admet-291	384	14	12	12	NUM
admet-291	384	15	(	(	PUNCT
admet-291	384	16	2015	2015	NUM
admet-291	384	17	)	)	PUNCT
admet-291	384	18	1456	1456	NUM
admet-291	384	19	-	-	SYM
admet-291	384	20	1466	1466	NUM
admet-291	384	21	.	.	PUNCT
admet-291	385	1	75	75	NUM
admet-291	386	1	[	[	SYM
admet-291	386	2	30	30	NUM
admet-291	386	3	]	]	X
admet-291	386	4	f.	f.	PROPN
admet-291	386	5	lovering	lovering	PROPN
admet-291	386	6	,	,	PUNCT
admet-291	386	7	j.	j.	PROPN
admet-291	386	8	bikker	bikker	PROPN
admet-291	386	9	,	,	PUNCT
admet-291	386	10	c.	c.	PROPN
admet-291	386	11	humblet	humblet	PROPN
admet-291	386	12	,	,	PUNCT
admet-291	386	13	journal	journal	NOUN
admet-291	386	14	of	of	ADP
admet-291	386	15	medicinal	medicinal	ADJ
admet-291	386	16	chemistry	chemistry	NOUN
admet-291	386	17	52	52	NUM
admet-291	386	18	(	(	PUNCT
admet-291	386	19	2009	2009	NUM
admet-291	386	20	)	)	PUNCT
admet-291	386	21	6752–6756	6752–6756	NUM
admet-291	386	22	.	.	PUNCT
admet-291	387	1	76	76	NUM
admet-291	388	1	[	[	X
admet-291	388	2	31	31	NUM
admet-291	388	3	]	]	X
admet-291	388	4	j.d	j.d	PROPN
admet-291	388	5	.	.	PROPN
admet-291	388	6	hughes	hughes	PROPN
admet-291	388	7	j.	j.	PROPN
admet-291	388	8	blagg	blagg	PROPN
admet-291	388	9	,	,	PUNCT
admet-291	388	10	d.a	d.a	PROPN
admet-291	388	11	.	.	PROPN
admet-291	388	12	price	price	NOUN
admet-291	388	13	,	,	PUNCT
admet-291	388	14	s.	s.	PROPN
admet-291	388	15	bailey	bailey	PROPN
admet-291	388	16	,	,	PUNCT
admet-291	388	17	g.a	g.a	PROPN
admet-291	388	18	.	.	PROPN
admet-291	388	19	decrescenzo	decrescenzo	PROPN
admet-291	388	20	,	,	PUNCT
admet-291	388	21	r.v	r.v	PROPN
admet-291	388	22	.	.	PROPN
admet-291	388	23	devraj	devraj	PROPN
admet-291	388	24	,	,	PUNCT
admet-291	388	25	e.	e.	PROPN
admet-291	388	26	ellsworth	ellsworth	PROPN
admet-291	388	27	,	,	PUNCT
admet-291	388	28	y.m	y.m	PROPN
admet-291	388	29	.	.	PROPN
admet-291	388	30	fobian	fobian	PROPN
admet-291	388	31	,	,	PUNCT
admet-291	388	32	77	77	NUM
admet-291	388	33	m.e	m.e	PROPN
admet-291	388	34	.	.	PROPN
admet-291	388	35	gibbs	gibbs	PROPN
admet-291	388	36	,	,	PUNCT
admet-291	388	37	r.w	r.w	PROPN
admet-291	388	38	.	.	PROPN
admet-291	388	39	gilles	gilles	PROPN
admet-291	388	40	,	,	PUNCT
admet-291	388	41	n.	n.	PROPN
admet-291	388	42	greene	greene	PROPN
admet-291	388	43	,	,	PUNCT
admet-291	388	44	e.	e.	PROPN
admet-291	388	45	huang	huang	PROPN
admet-291	388	46	,	,	PUNCT
admet-291	388	47	t.	t.	PROPN
admet-291	388	48	krieger	krieger	PROPN
admet-291	388	49	-	-	PUNCT
admet-291	388	50	burke	burke	PROPN
admet-291	388	51	,	,	PUNCT
admet-291	388	52	j.	j.	PROPN
admet-291	388	53	loesel	loesel	PROPN
admet-291	388	54	,	,	PUNCT
admet-291	388	55	t.	t.	NOUN
admet-291	388	56	wager	wager	NOUN
admet-291	388	57	,	,	PUNCT
admet-291	388	58	l.	l.	PROPN
admet-291	388	59	whiteley	whiteley	PROPN
admet-291	388	60	,	,	PUNCT
admet-291	388	61	y.	y.	PROPN
admet-291	388	62	78	78	NUM
admet-291	388	63	zhang	zhang	PROPN
admet-291	388	64	,	,	PUNCT
admet-291	388	65	bioorganic	bioorganic	PROPN
admet-291	388	66	&	&	CCONJ
admet-291	388	67	medicinal	medicinal	ADJ
admet-291	388	68	chemistry	chemistry	NOUN
admet-291	388	69	letters	letter	NOUN
admet-291	388	70	18	18	NUM
admet-291	388	71	(	(	PUNCT
admet-291	388	72	2008	2008	NUM
admet-291	388	73	)	)	PUNCT
admet-291	388	74	4872–4875	4872–4875	NUM
admet-291	388	75	.	.	PUNCT
admet-291	389	1	79	79	NUM
admet-291	390	1	[	[	X
admet-291	390	2	32	32	NUM
admet-291	390	3	]	]	PUNCT
admet-291	390	4	d.	d.	NOUN
admet-291	390	5	muthas	muthas	PROPN
admet-291	390	6	,	,	PUNCT
admet-291	390	7	s.	s.	PROPN
admet-291	390	8	boyera	boyera	PROPN
admet-291	390	9	,	,	PUNCT
admet-291	390	10	c.	c.	PROPN
admet-291	390	11	hasselgren	hasselgren	PROPN
admet-291	390	12	,	,	PUNCT
admet-291	390	13	medicinal	medicinal	ADJ
admet-291	390	14	chemical	chemical	NOUN
admet-291	390	15	communications	communication	NOUN
admet-291	390	16	4	4	NUM
admet-291	390	17	(	(	PUNCT
admet-291	390	18	2013	2013	NUM
admet-291	390	19	)	)	PUNCT
admet-291	390	20	1058–1065	1058–1065	NUM
admet-291	390	21	.	.	PUNCT
admet-291	391	1	80	80	NUM
admet-291	392	1	[	[	SYM
admet-291	392	2	33	33	NUM
admet-291	392	3	]	]	X
admet-291	392	4	j.j	j.j	PROPN
admet-291	392	5	.	.	PROPN
admet-291	392	6	sutherland	sutherland	PROPN
admet-291	392	7	,	,	PUNCT
admet-291	392	8	j.w	j.w	PROPN
admet-291	392	9	.	.	PROPN
admet-291	392	10	raymond	raymond	PROPN
admet-291	392	11	,	,	PUNCT
admet-291	392	12	j.l	j.l	PROPN
admet-291	392	13	.	.	PROPN
admet-291	392	14	stevens	stevens	PROPN
admet-291	392	15	,	,	PUNCT
admet-291	392	16	t.k	t.k	PROPN
admet-291	392	17	.	.	PROPN
admet-291	392	18	baker	baker	PROPN
admet-291	392	19	,	,	PUNCT
admet-291	392	20	d.e	d.e	PROPN
admet-291	392	21	.	.	PROPN
admet-291	392	22	watson	watson	PROPN
admet-291	392	23	,	,	PUNCT
admet-291	392	24	journal	journal	NOUN
admet-291	392	25	of	of	ADP
admet-291	392	26	medicinal	medicinal	ADJ
admet-291	392	27	81	81	NUM
admet-291	392	28	chemistry	chemistry	NOUN
admet-291	392	29	55	55	NUM
admet-291	392	30	(	(	PUNCT
admet-291	392	31	2012	2012	NUM
admet-291	392	32	)	)	PUNCT
admet-291	392	33	6455–6466	6455–6466	NUM
admet-291	392	34	.	.	PUNCT
admet-291	393	1	82	82	NUM
admet-291	393	2	83	83	NUM
admet-291	393	3	84	84	NUM
admet-291	393	4	©	©	PROPN
admet-291	393	5	2016	2016	NUM
admet-291	393	6	by	by	ADP
admet-291	393	7	the	the	DET
admet-291	393	8	authors	author	NOUN
admet-291	393	9	;	;	PUNCT
admet-291	393	10	licensee	licensee	PROPN
admet-291	393	11	iapc	iapc	PROPN
admet-291	393	12	,	,	PUNCT
admet-291	393	13	zagreb	zagreb	PROPN
admet-291	393	14	,	,	PUNCT
admet-291	393	15	croatia	croatia	PROPN
admet-291	393	16	.	.	PUNCT
admet-291	394	1	this	this	DET
admet-291	394	2	article	article	NOUN
admet-291	394	3	is	be	AUX
admet-291	394	4	an	an	DET
admet-291	394	5	open	open	ADJ
admet-291	394	6	-	-	PUNCT
admet-291	394	7	access	access	NOUN
admet-291	394	8	article	article	NOUN
admet-291	394	9	distributed	distribute	VERB
admet-291	394	10	under	under	ADP
admet-291	394	11	the	the	DET
admet-291	394	12	terms	term	NOUN
admet-291	394	13	and	and	CCONJ
admet-291	394	14	85	85	NUM
admet-291	394	15	conditions	condition	NOUN
admet-291	394	16	of	of	ADP
admet-291	394	17	the	the	DET
admet-291	394	18	creative	creative	ADJ
admet-291	394	19	commons	common	NOUN
admet-291	394	20	attribution	attribution	NOUN
admet-291	394	21	license	license	NOUN
admet-291	394	22	(	(	PUNCT
admet-291	394	23	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-291	394	24	)	)	PUNCT
admet-291	394	25	86	86	NUM
admet-291	394	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN