id	sid	tid	token	lemma	pos
admet-292	1	1	manuscript	manuscript	PROPN
admet-292	1	2	doi	doi	PROPN
admet-292	1	3	:	:	PUNCT
admet-292	1	4	10.5599	10.5599	NUM
admet-292	1	5	/	/	SYM
admet-292	1	6	admet.4.2.292	admet.4.2.292	PROPN
admet-292	1	7	117	117	NUM
admet-292	1	8	admet	admet	X
admet-292	1	9	&	&	CCONJ
admet-292	1	10	dmpk	dmpk	PROPN
admet-292	1	11	4(2	4(2	NUM
admet-292	1	12	)	)	PUNCT
admet-292	1	13	(	(	PUNCT
admet-292	1	14	2016	2016	NUM
admet-292	1	15	)	)	PUNCT
admet-292	1	16	117	117	NUM
admet-292	1	17	-	-	SYM
admet-292	1	18	178	178	NUM
admet-292	1	19	;	;	PUNCT
admet-292	1	20	doi	doi	NOUN
admet-292	1	21	:	:	PUNCT
admet-292	1	22	10.5599	10.5599	NUM
admet-292	1	23	/	/	SYM
admet-292	1	24	admet.4.2.292	admet.4.2.292	PRON
admet-292	1	25	open	open	ADJ
admet-292	1	26	access	access	NOUN
admet-292	1	27	:	:	PUNCT
admet-292	1	28	issn	issn	PROPN
admet-292	1	29	:	:	PUNCT
admet-292	1	30	1848	1848	NUM
admet-292	1	31	-	-	SYM
admet-292	1	32	7718	7718	NUM
admet-292	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-292	1	34	white	white	PROPN
admet-292	1	35	paper	paper	PROPN
admet-292	1	36	equilibrium	equilibrium	NOUN
admet-292	1	37	solubility	solubility	NOUN
admet-292	1	38	measurement	measurement	NOUN
admet-292	1	39	of	of	ADP
admet-292	1	40	ionizable	ionizable	ADJ
admet-292	1	41	drugs	drug	NOUN
admet-292	1	42	–	–	PUNCT
admet-292	1	43	consensus	consensus	NOUN
admet-292	1	44	recommendations	recommendation	NOUN
admet-292	1	45	for	for	ADP
admet-292	1	46	improving	improve	VERB
admet-292	1	47	data	datum	NOUN
admet-292	1	48	quality	quality	NOUN
admet-292	1	49	alex	alex	PROPN
admet-292	1	50	avdeef,1	avdeef,1	NOUN
admet-292	1	51	,	,	PUNCT
admet-292	1	52	*	*	PUNCT
admet-292	1	53	elisabet	elisabet	NOUN
admet-292	1	54	fuguet,2,3	fuguet,2,3	PROPN
admet-292	1	55	antonio	antonio	PROPN
admet-292	1	56	llinàs,4	llinàs,4	PROPN
admet-292	1	57	clara	clara	PROPN
admet-292	1	58	ràfols,2	ràfols,2	NOUN
admet-292	1	59	elisabeth	elisabeth	PROPN
admet-292	1	60	bosch,2	bosch,2	PROPN
admet-292	1	61	gergely	gergely	ADV
admet-292	1	62	völgyi,5	völgyi,5	VERB
admet-292	1	63	tatjana	tatjana	PROPN
admet-292	1	64	verbić,6	verbić,6	PROPN
admet-292	1	65	elena	elena	PROPN
admet-292	1	66	boldyreva7	boldyreva7	PROPN
admet-292	1	67	,	,	PUNCT
admet-292	1	68	krisztina	krisztina	PROPN
admet-292	1	69	takács	takács	PROPN
admet-292	1	70	-	-	PUNCT
admet-292	1	71	novák5	novák5	NOUN
admet-292	1	72	1	1	NUM
admet-292	1	73	in	in	ADP
admet-292	1	74	-	-	PUNCT
admet-292	1	75	adme	adme	NOUN
admet-292	1	76	research	research	NOUN
admet-292	1	77	,	,	PUNCT
admet-292	1	78	1732	1732	NUM
admet-292	1	79	first	first	ADJ
admet-292	1	80	avenue	avenue	PROPN
admet-292	1	81	,	,	PUNCT
admet-292	1	82	#	#	SYM
admet-292	1	83	102	102	NUM
admet-292	1	84	,	,	PUNCT
admet-292	1	85	new	new	PROPN
admet-292	1	86	york	york	PROPN
admet-292	1	87	,	,	PUNCT
admet-292	1	88	ny	ny	PROPN
admet-292	1	89	10128	10128	NUM
admet-292	1	90	,	,	PUNCT
admet-292	1	91	usa	usa	PROPN
admet-292	1	92	2	2	NUM
admet-292	1	93	departament	departament	NOUN
admet-292	1	94	de	de	PROPN
admet-292	1	95	química	química	PROPN
admet-292	1	96	analítica	analítica	PROPN
admet-292	1	97	and	and	CCONJ
admet-292	1	98	institut	institut	PROPN
admet-292	1	99	de	de	PROPN
admet-292	1	100	biomedicina	biomedicina	PROPN
admet-292	1	101	(	(	PUNCT
admet-292	1	102	ibub	ibub	PROPN
admet-292	1	103	)	)	PUNCT
admet-292	1	104	,	,	PUNCT
admet-292	1	105	universitat	universitat	PROPN
admet-292	1	106	de	de	PROPN
admet-292	1	107	barcelona	barcelona	PROPN
admet-292	1	108	,	,	PUNCT
admet-292	1	109	martí	martí	NOUN
admet-292	1	110	i	i	PRON
admet-292	1	111	franquès	franquès	ADV
admet-292	1	112	1	1	NUM
admet-292	1	113	-	-	SYM
admet-292	1	114	11	11	NUM
admet-292	1	115	,	,	PUNCT
admet-292	1	116	e08028	e08028	PROPN
admet-292	1	117	barcelona	barcelona	PROPN
admet-292	1	118	,	,	PUNCT
admet-292	1	119	spain	spain	PROPN
admet-292	1	120	3	3	NUM
admet-292	1	121	serra	serra	PROPN
admet-292	1	122	-	-	PUNCT
admet-292	1	123	húnter	húnter	PROPN
admet-292	1	124	program	program	NOUN
admet-292	1	125	,	,	PUNCT
admet-292	1	126	generalitat	generalitat	PROPN
admet-292	1	127	de	de	PROPN
admet-292	1	128	catalunya	catalunya	PROPN
admet-292	1	129	,	,	PUNCT
admet-292	1	130	barcelona	barcelona	PROPN
admet-292	1	131	,	,	PUNCT
admet-292	1	132	spain	spain	PROPN
admet-292	1	133	4	4	NUM
admet-292	1	134	ria	ria	PROPN
admet-292	1	135	imed	imed	PROPN
admet-292	1	136	dmpk	dmpk	PROPN
admet-292	1	137	,	,	PUNCT
admet-292	1	138	astrazeneca	astrazeneca	PROPN
admet-292	1	139	r&d	r&d	PROPN
admet-292	1	140	,	,	PUNCT
admet-292	1	141	gothenburg	gothenburg	PROPN
admet-292	1	142	,	,	PUNCT
admet-292	1	143	sweden	sweden	PROPN
admet-292	1	144	5	5	NUM
admet-292	1	145	semmelweis	semmelweis	NOUN
admet-292	1	146	university	university	NOUN
admet-292	1	147	,	,	PUNCT
admet-292	1	148	dept	dept	NOUN
admet-292	1	149	.	.	PROPN
admet-292	1	150	of	of	ADP
admet-292	1	151	pharmaceutical	pharmaceutical	ADJ
admet-292	1	152	chemistry	chemistry	NOUN
admet-292	1	153	,	,	PUNCT
admet-292	1	154	h-1092	h-1092	PROPN
admet-292	1	155	budapest	budapest	NOUN
admet-292	1	156	,	,	PUNCT
admet-292	1	157	högyes	högyes	PROPN
admet-292	1	158	e.	e.	PROPN
admet-292	1	159	u.9	u.9	PROPN
admet-292	1	160	,	,	PUNCT
admet-292	1	161	hungary	hungary	PROPN
admet-292	1	162	6	6	NUM
admet-292	1	163	faculty	faculty	NOUN
admet-292	1	164	of	of	ADP
admet-292	1	165	chemistry	chemistry	NOUN
admet-292	1	166	,	,	PUNCT
admet-292	1	167	university	university	PROPN
admet-292	1	168	of	of	ADP
admet-292	1	169	belgrade	belgrade	PROPN
admet-292	1	170	,	,	PUNCT
admet-292	1	171	dept	dept	NOUN
admet-292	1	172	.	.	PROPN
admet-292	1	173	of	of	ADP
admet-292	1	174	analytical	analytical	ADJ
admet-292	1	175	chemistry	chemistry	NOUN
admet-292	1	176	,	,	PUNCT
admet-292	1	177	studentski	studentski	NOUN
admet-292	1	178	trg	trg	PROPN
admet-292	1	179	12	12	NUM
admet-292	1	180	-	-	SYM
admet-292	1	181	16	16	NUM
admet-292	1	182	,	,	PUNCT
admet-292	1	183	belgrade	belgrade	PROPN
admet-292	1	184	11158	11158	NUM
admet-292	1	185	,	,	PUNCT
admet-292	1	186	serbia	serbia	PROPN
admet-292	1	187	7	7	NUM
admet-292	1	188	institute	institute	PROPN
admet-292	1	189	of	of	ADP
admet-292	1	190	solid	solid	ADJ
admet-292	1	191	state	state	NOUN
admet-292	1	192	chemistry	chemistry	NOUN
admet-292	1	193	and	and	CCONJ
admet-292	1	194	mechanochemistry	mechanochemistry	PROPN
admet-292	1	195	sb	sb	PROPN
admet-292	1	196	ras	ras	PROPN
admet-292	1	197	,	,	PUNCT
admet-292	1	198	kutateladze	kutateladze	PROPN
admet-292	1	199	,	,	PUNCT
admet-292	1	200	18	18	NUM
admet-292	1	201	,	,	PUNCT
admet-292	1	202	novosibirsk	novosibirsk	PROPN
admet-292	1	203	,	,	PUNCT
admet-292	1	204	630128	630128	NUM
admet-292	1	205	russia	russia	PROPN
admet-292	1	206	*	*	PUNCT
admet-292	1	207	corresponding	correspond	VERB
admet-292	1	208	author	author	NOUN
admet-292	1	209	:	:	PUNCT
admet-292	1	210	e	e	NOUN
admet-292	1	211	-	-	NOUN
admet-292	1	212	mail	mail	NOUN
admet-292	1	213	:	:	PUNCT
admet-292	1	214	alex@in-adme.com	alex@in-adme.com	NOUN
admet-292	1	215	;	;	PUNCT
admet-292	1	216	tel	tel	PROPN
admet-292	1	217	.	.	PUNCT
admet-292	1	218	:	:	PUNCT
admet-292	2	1	+1	+1	PROPN
admet-292	2	2	-	-	PUNCT
admet-292	2	3	646	646	NUM
admet-292	2	4	-	-	PUNCT
admet-292	2	5	678	678	NUM
admet-292	2	6	-	-	SYM
admet-292	2	7	5713	5713	NUM
admet-292	2	8	received	receive	VERB
admet-292	2	9	:	:	PUNCT
admet-292	2	10	may	may	AUX
admet-292	2	11	08	08	NUM
admet-292	2	12	,	,	PUNCT
admet-292	2	13	2016	2016	NUM
admet-292	2	14	;	;	PUNCT
admet-292	2	15	revised	revise	VERB
admet-292	2	16	:	:	PUNCT
admet-292	2	17	june	june	PROPN
admet-292	2	18	21	21	NUM
admet-292	2	19	,	,	PUNCT
admet-292	2	20	2016	2016	NUM
admet-292	2	21	;	;	PUNCT
admet-292	2	22	published	publish	VERB
admet-292	2	23	:	:	PUNCT
admet-292	2	24	june	june	PROPN
admet-292	2	25	29	29	NUM
admet-292	2	26	,	,	PUNCT
admet-292	2	27	2016	2016	NUM
admet-292	2	28	abstract	abstract	NOUN
admet-292	2	29	this	this	DET
admet-292	2	30	commentary	commentary	NOUN
admet-292	2	31	addresses	address	NOUN
admet-292	2	32	data	datum	NOUN
admet-292	2	33	quality	quality	NOUN
admet-292	2	34	in	in	ADP
admet-292	2	35	equilibrium	equilibrium	NOUN
admet-292	2	36	solubility	solubility	NOUN
admet-292	2	37	measurement	measurement	NOUN
admet-292	2	38	in	in	ADP
admet-292	2	39	aqueous	aqueous	ADJ
admet-292	2	40	solution	solution	NOUN
admet-292	2	41	.	.	PUNCT
admet-292	3	1	broadly	broadly	ADV
admet-292	3	2	discussed	discuss	VERB
admet-292	3	3	is	be	AUX
admet-292	3	4	the	the	DET
admet-292	3	5	“	"	PUNCT
admet-292	3	6	gold	gold	ADJ
admet-292	3	7	standard	standard	NOUN
admet-292	3	8	”	"	PUNCT
admet-292	3	9	shake	shake	NOUN
admet-292	3	10	-	-	PUNCT
admet-292	3	11	flask	flask	NOUN
admet-292	3	12	(	(	PUNCT
admet-292	3	13	sf	sf	NOUN
admet-292	3	14	)	)	PUNCT
admet-292	3	15	method	method	NOUN
admet-292	3	16	used	use	VERB
admet-292	3	17	to	to	PART
admet-292	3	18	measure	measure	VERB
admet-292	3	19	equilibrium	equilibrium	NOUN
admet-292	3	20	solubility	solubility	NOUN
admet-292	3	21	of	of	ADP
admet-292	3	22	ionizable	ionizable	ADJ
admet-292	3	23	drug	drug	NOUN
admet-292	3	24	-	-	PUNCT
admet-292	3	25	like	like	ADJ
admet-292	3	26	molecules	molecule	NOUN
admet-292	3	27	as	as	ADP
admet-292	3	28	a	a	DET
admet-292	3	29	function	function	NOUN
admet-292	3	30	of	of	ADP
admet-292	3	31	ph	ph	ADJ
admet-292	3	32	.	.	PUNCT
admet-292	4	1	many	many	ADJ
admet-292	4	2	factors	factor	NOUN
admet-292	4	3	affecting	affect	VERB
admet-292	4	4	the	the	DET
admet-292	4	5	quality	quality	NOUN
admet-292	4	6	of	of	ADP
admet-292	4	7	the	the	DET
admet-292	4	8	measurement	measurement	NOUN
admet-292	4	9	are	be	AUX
admet-292	4	10	recognized	recognize	VERB
admet-292	4	11	.	.	PUNCT
admet-292	5	1	case	case	NOUN
admet-292	5	2	studies	study	NOUN
admet-292	5	3	illustrating	illustrate	VERB
admet-292	5	4	the	the	DET
admet-292	5	5	analysis	analysis	NOUN
admet-292	5	6	of	of	ADP
admet-292	5	7	both	both	DET
admet-292	5	8	solution	solution	NOUN
admet-292	5	9	and	and	CCONJ
admet-292	5	10	solid	solid	ADJ
admet-292	5	11	state	state	NOUN
admet-292	5	12	aspects	aspect	NOUN
admet-292	5	13	of	of	ADP
admet-292	5	14	solubility	solubility	NOUN
admet-292	5	15	measurement	measurement	NOUN
admet-292	5	16	are	be	AUX
admet-292	5	17	presented	present	VERB
admet-292	5	18	.	.	PUNCT
admet-292	6	1	coverage	coverage	NOUN
admet-292	6	2	includes	include	VERB
admet-292	6	3	drug	drug	NOUN
admet-292	6	4	aggregation	aggregation	NOUN
admet-292	6	5	in	in	ADP
admet-292	6	6	solution	solution	NOUN
admet-292	6	7	(	(	PUNCT
admet-292	6	8	sub	sub	ADJ
admet-292	6	9	-	-	ADJ
admet-292	6	10	micellar	micellar	ADJ
admet-292	6	11	,	,	PUNCT
admet-292	6	12	micellar	micellar	NOUN
admet-292	6	13	,	,	PUNCT
admet-292	6	14	complexation	complexation	NOUN
admet-292	6	15	)	)	PUNCT
admet-292	6	16	,	,	PUNCT
admet-292	6	17	use	use	NOUN
admet-292	6	18	of	of	ADP
admet-292	6	19	mass	mass	ADJ
admet-292	6	20	spectrometry	spectrometry	NOUN
admet-292	6	21	to	to	PART
admet-292	6	22	assess	assess	VERB
admet-292	6	23	aggregation	aggregation	NOUN
admet-292	6	24	in	in	ADP
admet-292	6	25	saturated	saturate	VERB
admet-292	6	26	solutions	solution	NOUN
admet-292	6	27	,	,	PUNCT
admet-292	6	28	solid	solid	ADJ
admet-292	6	29	state	state	NOUN
admet-292	6	30	characterization	characterization	NOUN
admet-292	6	31	(	(	PUNCT
admet-292	6	32	salts	salt	NOUN
admet-292	6	33	,	,	PUNCT
admet-292	6	34	polymorphs	polymorph	NOUN
admet-292	6	35	,	,	PUNCT
admet-292	6	36	cocrystals	cocrystal	NOUN
admet-292	6	37	,	,	PUNCT
admet-292	6	38	polymorph	polymorph	NOUN
admet-292	6	39	creation	creation	NOUN
admet-292	6	40	by	by	ADP
admet-292	6	41	potentiometric	potentiometric	ADJ
admet-292	6	42	method	method	NOUN
admet-292	6	43	)	)	PUNCT
admet-292	6	44	,	,	PUNCT
admet-292	6	45	solubility	solubility	NOUN
admet-292	6	46	type	type	NOUN
admet-292	6	47	(	(	PUNCT
admet-292	6	48	water	water	NOUN
admet-292	6	49	,	,	PUNCT
admet-292	6	50	buffer	buffer	NOUN
admet-292	6	51	,	,	PUNCT
admet-292	6	52	intrinsic	intrinsic	ADJ
admet-292	6	53	)	)	PUNCT
admet-292	6	54	,	,	PUNCT
admet-292	6	55	temperature	temperature	NOUN
admet-292	6	56	,	,	PUNCT
admet-292	6	57	ionic	ionic	ADJ
admet-292	6	58	strength	strength	NOUN
admet-292	6	59	,	,	PUNCT
admet-292	6	60	ph	ph	ADJ
admet-292	6	61	measurement	measurement	NOUN
admet-292	6	62	,	,	PUNCT
admet-292	6	63	buffer	buffer	NOUN
admet-292	6	64	issues	issue	NOUN
admet-292	6	65	,	,	PUNCT
admet-292	6	66	critical	critical	ADJ
admet-292	6	67	knowledge	knowledge	NOUN
admet-292	6	68	of	of	ADP
admet-292	6	69	the	the	DET
admet-292	6	70	pka	pka	NOUN
admet-292	6	71	,	,	PUNCT
admet-292	6	72	equilibration	equilibration	NOUN
admet-292	6	73	time	time	NOUN
admet-292	6	74	(	(	PUNCT
admet-292	6	75	stirring	stirring	NOUN
admet-292	6	76	and	and	CCONJ
admet-292	6	77	sedimentation	sedimentation	NOUN
admet-292	6	78	)	)	PUNCT
admet-292	6	79	,	,	PUNCT
admet-292	6	80	separating	separate	VERB
admet-292	6	81	solid	solid	ADV
admet-292	6	82	from	from	ADP
admet-292	6	83	saturated	saturated	ADJ
admet-292	6	84	solution	solution	NOUN
admet-292	6	85	,	,	PUNCT
admet-292	6	86	solution	solution	NOUN
admet-292	6	87	handling	handling	NOUN
admet-292	6	88	and	and	CCONJ
admet-292	6	89	adsorption	adsorption	NOUN
admet-292	6	90	to	to	ADP
admet-292	6	91	untreated	untreated	ADJ
admet-292	6	92	surfaces	surface	NOUN
admet-292	6	93	,	,	PUNCT
admet-292	6	94	solubility	solubility	NOUN
admet-292	6	95	units	unit	NOUN
admet-292	6	96	,	,	PUNCT
admet-292	6	97	and	and	CCONJ
admet-292	6	98	tabulation	tabulation	NOUN
admet-292	6	99	/	/	SYM
admet-292	6	100	graphic	graphic	ADJ
admet-292	6	101	presentation	presentation	NOUN
admet-292	6	102	of	of	ADP
admet-292	6	103	reported	report	VERB
admet-292	6	104	data	datum	NOUN
admet-292	6	105	.	.	PUNCT
admet-292	7	1	the	the	DET
admet-292	7	2	goal	goal	NOUN
admet-292	7	3	is	be	AUX
admet-292	7	4	to	to	PART
admet-292	7	5	present	present	VERB
admet-292	7	6	cohesive	cohesive	ADJ
admet-292	7	7	recommendations	recommendation	NOUN
admet-292	7	8	that	that	PRON
admet-292	7	9	could	could	AUX
admet-292	7	10	lead	lead	VERB
admet-292	7	11	to	to	ADP
admet-292	7	12	better	well	ADJ
admet-292	7	13	assay	assay	VERB
admet-292	7	14	design	design	NOUN
admet-292	7	15	,	,	PUNCT
admet-292	7	16	to	to	PART
admet-292	7	17	result	result	VERB
admet-292	7	18	in	in	ADP
admet-292	7	19	improved	improved	ADJ
admet-292	7	20	quality	quality	NOUN
admet-292	7	21	of	of	ADP
admet-292	7	22	measurements	measurement	NOUN
admet-292	7	23	,	,	PUNCT
admet-292	7	24	and	and	CCONJ
admet-292	7	25	to	to	PART
admet-292	7	26	impart	impart	VERB
admet-292	7	27	a	a	DET
admet-292	7	28	deeper	deep	ADJ
admet-292	7	29	understanding	understanding	NOUN
admet-292	7	30	of	of	ADP
admet-292	7	31	the	the	DET
admet-292	7	32	underlying	underlying	ADJ
admet-292	7	33	solution	solution	NOUN
admet-292	7	34	chemistry	chemistry	NOUN
admet-292	7	35	in	in	ADP
admet-292	7	36	suspensions	suspension	NOUN
admet-292	7	37	of	of	ADP
admet-292	7	38	drug	drug	NOUN
admet-292	7	39	solids	solid	NOUN
admet-292	7	40	.	.	PUNCT
admet-292	8	1	keywords	keyword	VERB
admet-292	8	2	shake	shake	NOUN
admet-292	8	3	-	-	PUNCT
admet-292	8	4	flask	flask	NOUN
admet-292	8	5	solubility	solubility	NOUN
admet-292	8	6	;	;	PUNCT
admet-292	8	7	intrinsic	intrinsic	ADJ
admet-292	8	8	solubility	solubility	NOUN
admet-292	8	9	;	;	PUNCT
admet-292	8	10	water	water	NOUN
admet-292	8	11	solubility	solubility	NOUN
admet-292	8	12	;	;	PUNCT
admet-292	8	13	buffer	buffer	NOUN
admet-292	8	14	solubility	solubility	NOUN
admet-292	8	15	;	;	PUNCT
admet-292	8	16	thermodynamic	thermodynamic	ADJ
admet-292	8	17	solubility	solubility	NOUN
admet-292	8	18	;	;	PUNCT
admet-292	8	19	bjerrum	bjerrum	NOUN
admet-292	8	20	curve	curve	NOUN
admet-292	8	21	;	;	PUNCT
admet-292	8	22	cheqsol	cheqsol	ADJ
admet-292	8	23	;	;	PUNCT
admet-292	8	24	potentiometric	potentiometric	ADJ
admet-292	8	25	cycling	cycling	NOUN
admet-292	8	26	for	for	ADP
admet-292	8	27	polymorph	polymorph	NOUN
admet-292	8	28	creation	creation	NOUN
admet-292	8	29	;	;	PUNCT
admet-292	8	30	henderson	henderson	PROPN
admet-292	8	31	-	-	PUNCT
admet-292	8	32	hasselbalch	hasselbalch	PROPN
admet-292	8	33	equation	equation	NOUN
admet-292	8	34	;	;	PUNCT
admet-292	8	35	aggregates	aggregate	NOUN
admet-292	8	36	;	;	PUNCT
admet-292	8	37	oligomers	oligomer	NOUN
admet-292	8	38	;	;	PUNCT
admet-292	8	39	micelles	micelle	NOUN
admet-292	8	40	;	;	PUNCT
admet-292	8	41	hydrates	hydrate	NOUN
admet-292	8	42	;	;	PUNCT
admet-292	8	43	salts	salt	NOUN
admet-292	8	44	;	;	PUNCT
admet-292	8	45	polymorphs	polymorph	NOUN
admet-292	8	46	;	;	PUNCT
admet-292	8	47	cocrystals	cocrystal	NOUN
admet-292	8	48	.	.	PUNCT
admet-292	9	1	introduction	introduction	NOUN
admet-292	9	2	many	many	ADJ
admet-292	9	3	investigational	investigational	ADJ
admet-292	9	4	compounds	compound	NOUN
admet-292	9	5	in	in	ADP
admet-292	9	6	pharmaceutical	pharmaceutical	ADJ
admet-292	9	7	development	development	NOUN
admet-292	9	8	are	be	AUX
admet-292	9	9	practically	practically	ADV
admet-292	9	10	insoluble	insoluble	ADJ
admet-292	9	11	solids	solid	NOUN
admet-292	9	12	consisting	consist	VERB
admet-292	9	13	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-292	9	14	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-292	9	15	alex	alex	PROPN
admet-292	9	16	avdeef	avdeef	PROPN
admet-292	9	17	et	et	PROPN
admet-292	9	18	al	al	PROPN
admet-292	9	19	.	.	PROPN
admet-292	9	20	admet	admet	PROPN
admet-292	9	21	&	&	CCONJ
admet-292	9	22	dmpk	dmpk	PROPN
admet-292	9	23	4(2	4(2	NUM
admet-292	9	24	)	)	PUNCT
admet-292	9	25	(	(	PUNCT
admet-292	9	26	2016	2016	NUM
admet-292	9	27	)	)	PUNCT
admet-292	9	28	117	117	NUM
admet-292	9	29	-	-	SYM
admet-292	9	30	178	178	NUM
admet-292	9	31	118	118	NUM
admet-292	9	32	of	of	ADP
admet-292	9	33	ionizable	ionizable	ADJ
admet-292	9	34	molecules	molecule	NOUN
admet-292	9	35	.	.	PUNCT
admet-292	10	1	interpreting	interpret	VERB
admet-292	10	2	their	their	PRON
admet-292	10	3	solution	solution	NOUN
admet-292	10	4	properties	property	NOUN
admet-292	10	5	in	in	ADP
admet-292	10	6	the	the	DET
admet-292	10	7	course	course	NOUN
admet-292	10	8	of	of	ADP
admet-292	10	9	measuring	measure	VERB
admet-292	10	10	solubility	solubility	NOUN
admet-292	10	11	–	–	PUNCT
admet-292	10	12	as	as	ADP
admet-292	10	13	a	a	DET
admet-292	10	14	function	function	NOUN
admet-292	10	15	of	of	ADP
admet-292	10	16	ph	ph	NOUN
admet-292	10	17	–	–	PUNCT
admet-292	10	18	can	can	AUX
admet-292	10	19	be	be	AUX
admet-292	10	20	problematic	problematic	ADJ
admet-292	10	21	.	.	PUNCT
admet-292	11	1	although	although	SCONJ
admet-292	11	2	there	there	PRON
admet-292	11	3	are	be	VERB
admet-292	11	4	a	a	DET
admet-292	11	5	multitude	multitude	NOUN
admet-292	11	6	of	of	ADP
admet-292	11	7	published	publish	VERB
admet-292	11	8	methods	method	NOUN
admet-292	11	9	,	,	PUNCT
admet-292	11	10	today	today	NOUN
admet-292	11	11	’s	’s	PART
admet-292	11	12	druglike	druglike	NOUN
admet-292	11	13	molecules	molecule	NOUN
admet-292	11	14	can	can	AUX
admet-292	11	15	pose	pose	VERB
admet-292	11	16	special	special	ADJ
admet-292	11	17	challenges	challenge	NOUN
admet-292	11	18	,	,	PUNCT
admet-292	11	19	perhaps	perhaps	ADV
admet-292	11	20	not	not	PART
admet-292	11	21	adequately	adequately	ADV
admet-292	11	22	addressed	address	VERB
admet-292	11	23	in	in	ADP
admet-292	11	24	practice	practice	NOUN
admet-292	11	25	.	.	PUNCT
admet-292	12	1	the	the	DET
admet-292	12	2	published	publish	VERB
admet-292	12	3	literature	literature	NOUN
admet-292	12	4	is	be	AUX
admet-292	12	5	replete	replete	ADJ
admet-292	12	6	with	with	ADP
admet-292	12	7	incomplete	incomplete	ADJ
admet-292	12	8	/	/	SYM
admet-292	12	9	ambiguous	ambiguous	ADJ
admet-292	12	10	and	and	CCONJ
admet-292	12	11	potentially	potentially	ADV
admet-292	12	12	misleading	misleading	ADJ
admet-292	12	13	examples	example	NOUN
admet-292	12	14	of	of	ADP
admet-292	12	15	solubility	solubility	NOUN
admet-292	12	16	reports	report	VERB
admet-292	12	17	,	,	PUNCT
admet-292	12	18	frequently	frequently	ADV
admet-292	12	19	documented	document	VERB
admet-292	12	20	inconsistently	inconsistently	ADV
admet-292	12	21	.	.	PUNCT
admet-292	13	1	the	the	DET
admet-292	13	2	solubility	solubility	NOUN
admet-292	13	3	methodology	methodology	NOUN
admet-292	13	4	appears	appear	VERB
admet-292	13	5	to	to	PART
admet-292	13	6	be	be	AUX
admet-292	13	7	in	in	ADP
admet-292	13	8	need	need	NOUN
admet-292	13	9	of	of	ADP
admet-292	13	10	a	a	DET
admet-292	13	11	timely	timely	ADJ
admet-292	13	12	tune	tune	NOUN
admet-292	13	13	up	up	ADP
admet-292	13	14	.	.	PUNCT
admet-292	14	1	this	this	DET
admet-292	14	2	commentary	commentary	NOUN
admet-292	14	3	discusses	discuss	VERB
admet-292	14	4	ways	way	NOUN
admet-292	14	5	to	to	PART
admet-292	14	6	improve	improve	VERB
admet-292	14	7	the	the	DET
admet-292	14	8	measurement	measurement	NOUN
admet-292	14	9	of	of	ADP
admet-292	14	10	thermodynamic	thermodynamic	ADJ
admet-292	14	11	solubility	solubility	NOUN
admet-292	14	12	of	of	ADP
admet-292	14	13	druglike	druglike	ADJ
admet-292	14	14	substances	substance	NOUN
admet-292	14	15	in	in	ADP
admet-292	14	16	aqueous	aqueous	ADJ
admet-292	14	17	media	medium	NOUN
admet-292	14	18	.	.	PUNCT
admet-292	15	1	(	(	PUNCT
admet-292	15	2	topics	topic	NOUN
admet-292	15	3	such	such	ADJ
admet-292	15	4	as	as	ADP
admet-292	15	5	solubility	solubility	NOUN
admet-292	15	6	in	in	ADP
admet-292	15	7	bio	bio	ADJ
admet-292	15	8	-	-	ADJ
admet-292	15	9	relevant	relevant	ADJ
admet-292	15	10	media	medium	NOUN
admet-292	15	11	,	,	PUNCT
admet-292	15	12	kinetic	kinetic	ADJ
admet-292	15	13	solubility	solubility	NOUN
admet-292	15	14	,	,	PUNCT
admet-292	15	15	and	and	CCONJ
admet-292	15	16	solubility	solubility	NOUN
admet-292	15	17	of	of	ADP
admet-292	15	18	amorphous	amorphous	ADJ
admet-292	15	19	and	and	CCONJ
admet-292	15	20	of	of	ADP
admet-292	15	21	liquid	liquid	NOUN
admet-292	15	22	-	-	PUNCT
admet-292	15	23	liquid	liquid	ADJ
admet-292	15	24	phase	phase	NOUN
admet-292	15	25	separated	separate	VERB
admet-292	15	26	(	(	PUNCT
admet-292	15	27	llps	llp	NOUN
admet-292	15	28	)	)	PUNCT
admet-292	15	29	solids	solid	NOUN
admet-292	15	30	are	be	AUX
admet-292	15	31	outside	outside	ADP
admet-292	15	32	of	of	ADP
admet-292	15	33	its	its	PRON
admet-292	15	34	scope	scope	NOUN
admet-292	15	35	.	.	PUNCT
admet-292	15	36	)	)	PUNCT
admet-292	16	1	it	it	PRON
admet-292	16	2	is	be	AUX
admet-292	16	3	relatively	relatively	ADV
admet-292	16	4	scarce	scarce	ADJ
admet-292	16	5	to	to	PART
admet-292	16	6	find	find	VERB
admet-292	16	7	many	many	ADJ
admet-292	16	8	high	high	ADJ
admet-292	16	9	-	-	PUNCT
admet-292	16	10	quality	quality	NOUN
admet-292	16	11	solubility	solubility	NOUN
admet-292	16	12	measurements	measurement	NOUN
admet-292	16	13	that	that	PRON
admet-292	16	14	adequately	adequately	ADV
admet-292	16	15	cover	cover	VERB
admet-292	16	16	the	the	DET
admet-292	16	17	chemical	chemical	ADJ
admet-292	16	18	space	space	NOUN
admet-292	16	19	of	of	ADP
admet-292	16	20	drugs	drug	NOUN
admet-292	16	21	and	and	CCONJ
admet-292	16	22	research	research	NOUN
admet-292	16	23	compounds	compound	NOUN
admet-292	16	24	.	.	PUNCT
admet-292	17	1	measuring	measure	VERB
admet-292	17	2	such	such	ADJ
admet-292	17	3	data	datum	NOUN
admet-292	17	4	is	be	AUX
admet-292	17	5	expensive	expensive	ADJ
admet-292	17	6	and	and	CCONJ
admet-292	17	7	analytical	analytical	ADJ
admet-292	17	8	-	-	PUNCT
admet-292	17	9	resource	resource	NOUN
admet-292	17	10	consuming	consuming	NOUN
admet-292	17	11	.	.	PUNCT
admet-292	18	1	even	even	ADV
admet-292	18	2	with	with	ADP
admet-292	18	3	great	great	ADJ
admet-292	18	4	expense	expense	NOUN
admet-292	18	5	,	,	PUNCT
admet-292	18	6	quality	quality	NOUN
admet-292	18	7	is	be	AUX
admet-292	18	8	not	not	PART
admet-292	18	9	ensured	ensure	VERB
admet-292	18	10	when	when	SCONJ
admet-292	18	11	results	result	NOUN
admet-292	18	12	are	be	AUX
admet-292	18	13	determined	determine	VERB
admet-292	18	14	from	from	ADP
admet-292	18	15	under	under	ADV
admet-292	18	16	-	-	PUNCT
admet-292	18	17	designed	design	VERB
admet-292	18	18	assays	assay	NOUN
admet-292	18	19	.	.	PUNCT
admet-292	19	1	the	the	DET
admet-292	19	2	“	"	PUNCT
admet-292	19	3	solubility	solubility	NOUN
admet-292	19	4	challenge	challenge	NOUN
admet-292	19	5	”	"	PUNCT
admet-292	19	6	from	from	ADP
admet-292	19	7	llinàs	llinàs	PROPN
admet-292	19	8	et	et	PROPN
admet-292	19	9	al	al	PROPN
admet-292	19	10	.	.	PUNCT
admet-292	20	1	[	[	X
admet-292	20	2	1	1	X
admet-292	20	3	]	]	PUNCT
admet-292	20	4	and	and	CCONJ
admet-292	20	5	hopfinger	hopfinger	PROPN
admet-292	20	6	et	et	PROPN
admet-292	20	7	al	al	PROPN
admet-292	20	8	.	.	PUNCT
admet-292	21	1	[	[	X
admet-292	21	2	2	2	NUM
admet-292	21	3	]	]	PUNCT
admet-292	21	4	has	have	AUX
admet-292	21	5	spurred	spur	VERB
admet-292	21	6	fresh	fresh	ADJ
admet-292	21	7	discussion	discussion	NOUN
admet-292	21	8	about	about	ADP
admet-292	21	9	data	datum	NOUN
admet-292	21	10	quality	quality	NOUN
admet-292	21	11	in	in	ADP
admet-292	21	12	solubility	solubility	NOUN
admet-292	21	13	measurement	measurement	NOUN
admet-292	21	14	in	in	ADP
admet-292	21	15	pharmaceutical	pharmaceutical	ADJ
admet-292	21	16	research	research	NOUN
admet-292	21	17	.	.	PUNCT
admet-292	22	1	concomitantly	concomitantly	ADV
admet-292	22	2	,	,	PUNCT
admet-292	22	3	baka	baka	PROPN
admet-292	22	4	et	et	PROPN
admet-292	22	5	al	al	PROPN
admet-292	22	6	.	.	PUNCT
admet-292	23	1	[	[	X
admet-292	23	2	3	3	X
admet-292	23	3	]	]	PUNCT
admet-292	23	4	examined	examine	VERB
admet-292	23	5	the	the	DET
admet-292	23	6	classical	classical	ADJ
admet-292	23	7	saturation	saturation	NOUN
admet-292	23	8	shake	shake	NOUN
admet-292	23	9	-	-	PUNCT
admet-292	23	10	flask	flask	NOUN
admet-292	23	11	method	method	NOUN
admet-292	23	12	,	,	PUNCT
admet-292	23	13	to	to	PART
admet-292	23	14	assess	assess	VERB
admet-292	23	15	which	which	PRON
admet-292	23	16	experimental	experimental	ADJ
admet-292	23	17	conditions	condition	NOUN
admet-292	23	18	significantly	significantly	ADV
admet-292	23	19	affect	affect	VERB
admet-292	23	20	the	the	DET
admet-292	23	21	measured	measured	ADJ
admet-292	23	22	equilibrium	equilibrium	NOUN
admet-292	23	23	solubility	solubility	NOUN
admet-292	23	24	.	.	PUNCT
admet-292	24	1	more	more	ADV
admet-292	24	2	recently	recently	ADV
admet-292	24	3	,	,	PUNCT
admet-292	24	4	solubility	solubility	NOUN
admet-292	24	5	data	datum	NOUN
admet-292	24	6	quality	quality	NOUN
admet-292	24	7	has	have	AUX
admet-292	24	8	been	be	AUX
admet-292	24	9	reviewed	review	VERB
admet-292	24	10	by	by	ADP
admet-292	24	11	avdeef	avdeef	NOUN
admet-292	24	12	[	[	X
admet-292	24	13	4	4	NUM
admet-292	24	14	]	]	PUNCT
admet-292	24	15	.	.	PUNCT
admet-292	25	1	optimal	optimal	ADJ
admet-292	25	2	experimental	experimental	ADJ
admet-292	25	3	design	design	NOUN
admet-292	25	4	to	to	PART
admet-292	25	5	measure	measure	VERB
admet-292	25	6	the	the	DET
admet-292	25	7	aqueous	aqueous	ADJ
admet-292	25	8	equilibrium	equilibrium	NOUN
admet-292	25	9	solubility	solubility	NOUN
admet-292	25	10	of	of	ADP
admet-292	25	11	an	an	DET
admet-292	25	12	ionizable	ionizable	ADJ
admet-292	25	13	substance	substance	NOUN
admet-292	25	14	requires	require	VERB
admet-292	25	15	a	a	DET
admet-292	25	16	number	number	NOUN
admet-292	25	17	of	of	ADP
admet-292	25	18	critical	critical	ADJ
admet-292	25	19	considerations	consideration	NOUN
admet-292	25	20	.	.	PUNCT
admet-292	26	1	briefly	briefly	ADV
admet-292	26	2	,	,	PUNCT
admet-292	26	3	the	the	DET
admet-292	26	4	aqueous	aqueous	ADJ
admet-292	26	5	medium	medium	NOUN
admet-292	26	6	to	to	PART
admet-292	26	7	which	which	PRON
admet-292	26	8	the	the	DET
admet-292	26	9	substance	substance	NOUN
admet-292	26	10	is	be	AUX
admet-292	26	11	added	add	VERB
admet-292	26	12	ideally	ideally	ADV
admet-292	26	13	contains	contain	VERB
admet-292	26	14	a	a	DET
admet-292	26	15	buffer	buffer	NOUN
admet-292	26	16	to	to	PART
admet-292	26	17	help	help	VERB
admet-292	26	18	control	control	VERB
admet-292	26	19	the	the	DET
admet-292	26	20	ph	ph	NOUN
admet-292	26	21	.	.	PROPN
admet-292	26	22	to	to	ADP
admet-292	26	23	this	this	DET
admet-292	26	24	medium	medium	NOUN
admet-292	26	25	,	,	PUNCT
admet-292	26	26	the	the	DET
admet-292	26	27	substance	substance	NOUN
admet-292	26	28	may	may	AUX
admet-292	26	29	be	be	AUX
admet-292	26	30	added	add	VERB
admet-292	26	31	in	in	ADP
admet-292	26	32	a	a	DET
admet-292	26	33	number	number	NOUN
admet-292	26	34	of	of	ADP
admet-292	26	35	ways	way	NOUN
admet-292	26	36	:	:	PUNCT
admet-292	26	37	(	(	PUNCT
admet-292	26	38	a	a	X
admet-292	26	39	)	)	PUNCT
admet-292	26	40	as	as	ADP
admet-292	26	41	a	a	DET
admet-292	26	42	highly	highly	ADV
admet-292	26	43	supersaturated	supersaturated	ADJ
admet-292	26	44	aqueous	aqueous	ADJ
admet-292	26	45	solution	solution	NOUN
admet-292	26	46	,	,	PUNCT
admet-292	26	47	(	(	PUNCT
admet-292	26	48	b	b	X
admet-292	26	49	)	)	PUNCT
admet-292	26	50	as	as	ADP
admet-292	26	51	a	a	DET
admet-292	26	52	saturated	saturated	ADJ
admet-292	26	53	hot	hot	ADJ
admet-292	26	54	solution	solution	NOUN
admet-292	26	55	,	,	PUNCT
admet-292	26	56	(	(	PUNCT
admet-292	26	57	c	c	NOUN
admet-292	26	58	)	)	PUNCT
admet-292	26	59	as	as	ADP
admet-292	26	60	a	a	DET
admet-292	26	61	concentrated	concentrated	ADJ
admet-292	26	62	solution	solution	NOUN
admet-292	26	63	in	in	ADP
admet-292	26	64	a	a	DET
admet-292	26	65	water	water	NOUN
admet-292	26	66	-	-	PUNCT
admet-292	26	67	miscible	miscible	ADJ
admet-292	26	68	organic	organic	ADJ
admet-292	26	69	solvent	solvent	NOUN
admet-292	26	70	,	,	PUNCT
admet-292	26	71	or	or	CCONJ
admet-292	26	72	(	(	PUNCT
admet-292	26	73	d	d	NOUN
admet-292	26	74	)	)	PUNCT
admet-292	26	75	as	as	ADP
admet-292	26	76	a	a	DET
admet-292	26	77	solid	solid	ADJ
admet-292	26	78	–	–	PUNCT
admet-292	26	79	which	which	PRON
admet-292	26	80	may	may	AUX
admet-292	26	81	or	or	CCONJ
admet-292	26	82	may	may	AUX
admet-292	26	83	not	not	PART
admet-292	26	84	be	be	AUX
admet-292	26	85	in	in	ADP
admet-292	26	86	a	a	DET
admet-292	26	87	thermodynamically	thermodynamically	ADV
admet-292	26	88	stable	stable	ADJ
admet-292	26	89	form	form	NOUN
admet-292	26	90	.	.	PUNCT
admet-292	27	1	the	the	DET
admet-292	27	2	first	first	ADJ
admet-292	27	3	three	three	NUM
admet-292	27	4	approaches	approach	NOUN
admet-292	27	5	are	be	AUX
admet-292	27	6	precipitation	precipitation	NOUN
admet-292	27	7	routes	route	NOUN
admet-292	27	8	,	,	PUNCT
admet-292	27	9	while	while	SCONJ
admet-292	27	10	the	the	DET
admet-292	27	11	fourth	fourth	ADJ
admet-292	27	12	involves	involve	VERB
admet-292	27	13	dissolution	dissolution	NOUN
admet-292	27	14	.	.	PUNCT
admet-292	28	1	the	the	DET
admet-292	28	2	latter	latter	ADJ
admet-292	28	3	process	process	NOUN
admet-292	28	4	is	be	AUX
admet-292	28	5	most	most	ADV
admet-292	28	6	commonly	commonly	ADV
admet-292	28	7	used	use	VERB
admet-292	28	8	,	,	PUNCT
admet-292	28	9	best	well	ADV
admet-292	28	10	understood	understand	VERB
admet-292	28	11	,	,	PUNCT
admet-292	28	12	and	and	CCONJ
admet-292	28	13	is	be	AUX
admet-292	28	14	the	the	DET
admet-292	28	15	backbone	backbone	NOUN
admet-292	28	16	of	of	ADP
admet-292	28	17	the	the	DET
admet-292	28	18	commentary	commentary	NOUN
admet-292	28	19	here	here	ADV
admet-292	28	20	.	.	PUNCT
admet-292	29	1	solubility	solubility	NOUN
admet-292	29	2	reactions	reaction	NOUN
admet-292	29	3	,	,	PUNCT
admet-292	29	4	being	be	AUX
admet-292	29	5	heterogeneous	heterogeneous	ADJ
admet-292	29	6	,	,	PUNCT
admet-292	29	7	are	be	AUX
admet-292	29	8	often	often	ADV
admet-292	29	9	slow	slow	ADJ
admet-292	29	10	to	to	PART
admet-292	29	11	reach	reach	VERB
admet-292	29	12	equilibrium	equilibrium	NOUN
admet-292	29	13	,	,	PUNCT
admet-292	29	14	especially	especially	ADV
admet-292	29	15	in	in	ADP
admet-292	29	16	the	the	DET
admet-292	29	17	case	case	NOUN
admet-292	29	18	of	of	ADP
admet-292	29	19	lowsoluble	lowsoluble	ADJ
admet-292	29	20	substances	substance	NOUN
admet-292	29	21	.	.	PUNCT
admet-292	30	1	with	with	ADP
admet-292	30	2	sufficient	sufficient	ADJ
admet-292	30	3	added	add	VERB
admet-292	30	4	solid	solid	ADJ
admet-292	30	5	and	and	CCONJ
admet-292	30	6	enough	enough	ADJ
admet-292	30	7	time	time	NOUN
admet-292	30	8	,	,	PUNCT
admet-292	30	9	chemical	chemical	ADJ
admet-292	30	10	equilibrium	equilibrium	NOUN
admet-292	30	11	is	be	AUX
admet-292	30	12	expected	expect	VERB
admet-292	30	13	,	,	PUNCT
admet-292	30	14	where	where	SCONJ
admet-292	30	15	the	the	DET
admet-292	30	16	substance	substance	NOUN
admet-292	30	17	in	in	ADP
admet-292	30	18	its	its	PRON
admet-292	30	19	stable	stable	ADJ
admet-292	30	20	crystalline	crystalline	NOUN
admet-292	30	21	form	form	NOUN
admet-292	30	22	is	be	AUX
admet-292	30	23	in	in	ADP
admet-292	30	24	dynamic	dynamic	ADJ
admet-292	30	25	equilibrium	equilibrium	NOUN
admet-292	30	26	with	with	ADP
admet-292	30	27	its	its	PRON
admet-292	30	28	solution	solution	NOUN
admet-292	30	29	form	form	NOUN
admet-292	30	30	.	.	PUNCT
admet-292	31	1	as	as	ADP
admet-292	31	2	the	the	DET
admet-292	31	3	dissolution	dissolution	NOUN
admet-292	31	4	proceeds	proceed	NOUN
admet-292	31	5	,	,	PUNCT
admet-292	31	6	the	the	DET
admet-292	31	7	solid	solid	ADJ
admet-292	31	8	phase	phase	NOUN
admet-292	31	9	can	can	AUX
admet-292	31	10	re	re	VERB
admet-292	31	11	-	-	VERB
admet-292	31	12	precipitate	precipitate	ADJ
admet-292	31	13	as	as	ADP
admet-292	31	14	another	another	DET
admet-292	31	15	form	form	NOUN
admet-292	31	16	with	with	ADP
admet-292	31	17	another	another	DET
admet-292	31	18	structure	structure	NOUN
admet-292	31	19	(	(	PUNCT
admet-292	31	20	polymorphic	polymorphic	ADJ
admet-292	31	21	transitions	transition	NOUN
admet-292	31	22	)	)	PUNCT
admet-292	31	23	and	and	CCONJ
admet-292	31	24	even	even	ADV
admet-292	31	25	another	another	DET
admet-292	31	26	composition	composition	NOUN
admet-292	31	27	(	(	PUNCT
admet-292	31	28	formation	formation	NOUN
admet-292	31	29	of	of	ADP
admet-292	31	30	crystal	crystal	NOUN
admet-292	31	31	solvates	solvate	NOUN
admet-292	31	32	,	,	PUNCT
admet-292	31	33	salts	salt	NOUN
admet-292	31	34	,	,	PUNCT
admet-292	31	35	or	or	CCONJ
admet-292	31	36	loss	loss	NOUN
admet-292	31	37	of	of	ADP
admet-292	31	38	solvate	solvate	NOUN
admet-292	31	39	from	from	ADP
admet-292	31	40	the	the	DET
admet-292	31	41	starting	starting	NOUN
admet-292	31	42	solid	solid	NOUN
admet-292	31	43	)	)	PUNCT
admet-292	31	44	.	.	PUNCT
admet-292	32	1	dissolution	dissolution	NOUN
admet-292	32	2	of	of	ADP
admet-292	32	3	multi	multi	ADJ
admet-292	32	4	-	-	ADJ
admet-292	32	5	component	component	ADJ
admet-292	32	6	solids	solid	NOUN
admet-292	32	7	(	(	PUNCT
admet-292	32	8	salts	salt	NOUN
admet-292	32	9	–	–	PUNCT
admet-292	32	10	formed	form	VERB
admet-292	32	11	by	by	ADP
admet-292	32	12	cations	cation	NOUN
admet-292	32	13	and	and	CCONJ
admet-292	32	14	anions	anion	NOUN
admet-292	32	15	,	,	PUNCT
admet-292	32	16	or	or	CCONJ
admet-292	32	17	cocrystals	cocrystal	NOUN
admet-292	32	18	–	–	PUNCT
admet-292	32	19	formed	form	VERB
admet-292	32	20	by	by	ADP
admet-292	32	21	neutral	neutral	ADJ
admet-292	32	22	molecules	molecule	NOUN
admet-292	32	23	,	,	PUNCT
admet-292	32	24	a	a	DET
admet-292	32	25	drug	drug	NOUN
admet-292	32	26	and	and	CCONJ
admet-292	32	27	another	another	DET
admet-292	32	28	molecule	molecule	NOUN
admet-292	32	29	,	,	PUNCT
admet-292	32	30	termed	term	VERB
admet-292	32	31	a	a	DET
admet-292	32	32	“	"	PUNCT
admet-292	32	33	coformer	coformer	NOUN
admet-292	32	34	”	"	PUNCT
admet-292	32	35	,	,	PUNCT
admet-292	32	36	which	which	PRON
admet-292	32	37	are	be	AUX
admet-292	32	38	often	often	ADV
admet-292	32	39	strongly	strongly	ADV
admet-292	32	40	hydrogen	hydrogen	NOUN
admet-292	32	41	-	-	PUNCT
admet-292	32	42	bonded	bond	VERB
admet-292	32	43	)	)	PUNCT
admet-292	32	44	adds	add	VERB
admet-292	32	45	complexity	complexity	NOUN
admet-292	32	46	,	,	PUNCT
admet-292	32	47	since	since	SCONJ
admet-292	32	48	on	on	ADP
admet-292	32	49	their	their	PRON
admet-292	32	50	dissolution	dissolution	NOUN
admet-292	32	51	,	,	PUNCT
admet-292	32	52	re	re	NOUN
admet-292	32	53	-	-	NOUN
admet-292	32	54	crystallization	crystallization	NOUN
admet-292	32	55	of	of	ADP
admet-292	32	56	some	some	DET
admet-292	32	57	components	component	NOUN
admet-292	32	58	can	can	AUX
admet-292	32	59	start	start	VERB
admet-292	32	60	,	,	PUNCT
admet-292	32	61	depending	depend	VERB
admet-292	32	62	on	on	ADP
admet-292	32	63	the	the	DET
admet-292	32	64	solution	solution	NOUN
admet-292	32	65	conditions	condition	NOUN
admet-292	32	66	.	.	PUNCT
admet-292	33	1	the	the	DET
admet-292	33	2	values	value	NOUN
admet-292	33	3	of	of	ADP
admet-292	33	4	the	the	DET
admet-292	33	5	solubility	solubility	NOUN
admet-292	33	6	measured	measure	VERB
admet-292	33	7	at	at	ADP
admet-292	33	8	different	different	ADJ
admet-292	33	9	time	time	NOUN
admet-292	33	10	points	point	NOUN
admet-292	33	11	will	will	AUX
admet-292	33	12	therefore	therefore	ADV
admet-292	33	13	correspond	correspond	VERB
admet-292	33	14	to	to	ADP
admet-292	33	15	different	different	ADJ
admet-292	33	16	solid	solid	ADJ
admet-292	33	17	phases	phase	NOUN
admet-292	33	18	,	,	PUNCT
admet-292	33	19	not	not	PART
admet-292	33	20	necessarily	necessarily	ADV
admet-292	33	21	the	the	DET
admet-292	33	22	one	one	NOUN
admet-292	33	23	initially	initially	ADV
admet-292	33	24	introduced	introduce	VERB
admet-292	33	25	into	into	ADP
admet-292	33	26	solution	solution	NOUN
admet-292	33	27	.	.	PUNCT
admet-292	34	1	sometimes	sometimes	ADV
admet-292	34	2	a	a	DET
admet-292	34	3	long	long	ADJ
admet-292	34	4	equilibration	equilibration	NOUN
admet-292	34	5	time	time	NOUN
admet-292	34	6	is	be	AUX
admet-292	34	7	needed	need	VERB
admet-292	34	8	to	to	PART
admet-292	34	9	settle	settle	VERB
admet-292	34	10	to	to	ADP
admet-292	34	11	the	the	DET
admet-292	34	12	most	most	ADV
admet-292	34	13	stable	stable	ADJ
admet-292	34	14	crystalline	crystalline	NOUN
admet-292	34	15	form	form	NOUN
admet-292	34	16	.	.	PUNCT
admet-292	35	1	in	in	ADP
admet-292	35	2	solution	solution	NOUN
admet-292	35	3	,	,	PUNCT
admet-292	35	4	the	the	DET
admet-292	35	5	substance	substance	NOUN
admet-292	35	6	may	may	AUX
admet-292	35	7	undergo	undergo	VERB
admet-292	35	8	ionization	ionization	NOUN
admet-292	35	9	,	,	PUNCT
admet-292	35	10	self	self	NOUN
admet-292	35	11	-	-	PUNCT
admet-292	35	12	aggregation	aggregation	NOUN
admet-292	35	13	(	(	PUNCT
admet-292	35	14	forming	form	VERB
admet-292	35	15	water	water	NOUN
admet-292	35	16	-	-	PUNCT
admet-292	35	17	soluble	soluble	ADJ
admet-292	35	18	dimers	dimer	NOUN
admet-292	35	19	,	,	PUNCT
admet-292	35	20	trimers	trimer	NOUN
admet-292	35	21	,	,	PUNCT
admet-292	35	22	etc	etc	X
admet-292	35	23	.	.	X
admet-292	35	24	,	,	PUNCT
admet-292	35	25	or	or	CCONJ
admet-292	35	26	micelles	micelle	NOUN
admet-292	35	27	in	in	ADP
admet-292	35	28	the	the	DET
admet-292	35	29	case	case	NOUN
admet-292	35	30	of	of	ADP
admet-292	35	31	amphiphilic	amphiphilic	ADJ
admet-292	35	32	substances	substance	NOUN
admet-292	35	33	)	)	PUNCT
admet-292	35	34	,	,	PUNCT
admet-292	35	35	or	or	CCONJ
admet-292	35	36	complexation	complexation	NOUN
admet-292	35	37	with	with	ADP
admet-292	35	38	some	some	PRON
admet-292	35	39	of	of	ADP
admet-292	35	40	the	the	DET
admet-292	35	41	buffer	buffer	NOUN
admet-292	35	42	components	component	NOUN
admet-292	35	43	.	.	PUNCT
admet-292	36	1	in	in	ADP
admet-292	36	2	some	some	DET
admet-292	36	3	cases	case	NOUN
admet-292	36	4	,	,	PUNCT
admet-292	36	5	solids	solid	NOUN
admet-292	36	6	dissolve	dissolve	VERB
admet-292	36	7	as	as	ADP
admet-292	36	8	clusters	cluster	NOUN
admet-292	36	9	of	of	ADP
admet-292	36	10	molecules	molecule	NOUN
admet-292	36	11	,	,	PUNCT
admet-292	36	12	which	which	PRON
admet-292	36	13	can	can	AUX
admet-292	36	14	be	be	AUX
admet-292	36	15	preserved	preserve	VERB
admet-292	36	16	for	for	ADP
admet-292	36	17	some	some	DET
admet-292	36	18	time	time	NOUN
admet-292	36	19	before	before	ADP
admet-292	36	20	being	be	AUX
admet-292	36	21	broken	break	VERB
admet-292	36	22	apart	apart	ADV
admet-292	36	23	by	by	ADP
admet-292	36	24	the	the	DET
admet-292	36	25	solvent	solvent	NOUN
admet-292	36	26	.	.	PUNCT
admet-292	37	1	at	at	ADP
admet-292	37	2	true	true	ADJ
admet-292	37	3	dynamic	dynamic	ADJ
admet-292	37	4	equilibrium	equilibrium	NOUN
admet-292	37	5	,	,	PUNCT
admet-292	37	6	the	the	DET
admet-292	37	7	forward	forward	ADJ
admet-292	37	8	(	(	PUNCT
admet-292	37	9	dissolution	dissolution	NOUN
admet-292	37	10	)	)	PUNCT
admet-292	37	11	and	and	CCONJ
admet-292	37	12	reverse	reverse	ADJ
admet-292	37	13	(	(	PUNCT
admet-292	37	14	precipitation	precipitation	NOUN
admet-292	37	15	)	)	PUNCT
admet-292	37	16	reaction	reaction	NOUN
admet-292	37	17	rates	rate	NOUN
admet-292	37	18	are	be	AUX
admet-292	37	19	equal	equal	ADJ
admet-292	37	20	to	to	ADP
admet-292	37	21	one	one	NUM
admet-292	37	22	another	another	DET
admet-292	37	23	.	.	PUNCT
admet-292	38	1	in	in	ADP
admet-292	38	2	this	this	DET
admet-292	38	3	dynamically	dynamically	ADV
admet-292	38	4	equilibrated	equilibrate	VERB
admet-292	38	5	saturated	saturated	ADJ
admet-292	38	6	solution	solution	NOUN
admet-292	38	7	,	,	PUNCT
admet-292	38	8	the	the	DET
admet-292	38	9	concentration	concentration	NOUN
admet-292	38	10	of	of	ADP
admet-292	38	11	the	the	DET
admet-292	38	12	drug	drug	NOUN
admet-292	38	13	substance	substance	NOUN
admet-292	38	14	(	(	PUNCT
admet-292	38	15	summed	sum	VERB
admet-292	38	16	over	over	ADP
admet-292	38	17	all	all	PRON
admet-292	38	18	of	of	ADP
admet-292	38	19	its	its	PRON
admet-292	38	20	dissolved	dissolve	VERB
admet-292	38	21	forms	form	NOUN
admet-292	38	22	)	)	PUNCT
admet-292	38	23	is	be	AUX
admet-292	38	24	the	the	DET
admet-292	38	25	solubility	solubility	NOUN
admet-292	38	26	.	.	PUNCT
admet-292	39	1	both	both	DET
admet-292	39	2	phases	phase	NOUN
admet-292	39	3	of	of	ADP
admet-292	39	4	the	the	DET
admet-292	39	5	solubility	solubility	NOUN
admet-292	39	6	process	process	NOUN
admet-292	39	7	are	be	AUX
admet-292	39	8	important	important	ADJ
admet-292	39	9	to	to	PART
admet-292	39	10	consider	consider	VERB
admet-292	39	11	,	,	PUNCT
admet-292	39	12	as	as	ADP
admet-292	39	13	admet	admet	PROPN
admet-292	39	14	&	&	CCONJ
admet-292	39	15	dmpk	dmpk	PROPN
admet-292	39	16	4(2	4(2	NUM
admet-292	39	17	)	)	PUNCT
admet-292	39	18	(	(	PUNCT
admet-292	39	19	2016	2016	NUM
admet-292	39	20	)	)	PUNCT
admet-292	39	21	117	117	NUM
admet-292	39	22	-	-	SYM
admet-292	39	23	178	178	NUM
admet-292	39	24	consensus	consensus	NOUN
admet-292	39	25	recommendations	recommendation	NOUN
admet-292	39	26	for	for	ADP
admet-292	39	27	improving	improve	VERB
admet-292	39	28	solubility	solubility	NOUN
admet-292	39	29	-	-	PUNCT
admet-292	39	30	ph	ph	ADJ
admet-292	39	31	data	datum	NOUN
admet-292	39	32	quality	quality	NOUN
admet-292	39	33	doi	doi	NOUN
admet-292	39	34	:	:	PUNCT
admet-292	39	35	10.5599	10.5599	NUM
admet-292	39	36	/	/	SYM
admet-292	39	37	admet.4.2.292	admet.4.2.292	NUM
admet-292	39	38	119	119	NUM
admet-292	39	39	measured	measure	VERB
admet-292	39	40	solubility	solubility	NOUN
admet-292	39	41	depends	depend	VERB
admet-292	39	42	both	both	PRON
admet-292	39	43	on	on	ADP
admet-292	39	44	the	the	DET
admet-292	39	45	solid	solid	ADJ
admet-292	39	46	and	and	CCONJ
admet-292	39	47	the	the	DET
admet-292	39	48	solution	solution	NOUN
admet-292	39	49	forms	form	NOUN
admet-292	39	50	.	.	PUNCT
admet-292	40	1	since	since	SCONJ
admet-292	40	2	the	the	DET
admet-292	40	3	solubility	solubility	NOUN
admet-292	40	4	is	be	AUX
admet-292	40	5	temperature	temperature	NOUN
admet-292	40	6	dependent	dependent	ADJ
admet-292	40	7	,	,	PUNCT
admet-292	40	8	the	the	DET
admet-292	40	9	temperature	temperature	NOUN
admet-292	40	10	needs	need	VERB
admet-292	40	11	to	to	PART
admet-292	40	12	be	be	AUX
admet-292	40	13	controlled	control	VERB
admet-292	40	14	.	.	PUNCT
admet-292	41	1	for	for	ADP
admet-292	41	2	ionizable	ionizable	ADJ
admet-292	41	3	substances	substance	NOUN
admet-292	41	4	,	,	PUNCT
admet-292	41	5	solubility	solubility	NOUN
admet-292	41	6	depends	depend	VERB
admet-292	41	7	on	on	ADP
admet-292	41	8	ph	ph	ADJ
admet-292	41	9	,	,	PUNCT
admet-292	41	10	so	so	CCONJ
admet-292	41	11	the	the	DET
admet-292	41	12	final	final	ADJ
admet-292	41	13	(	(	PUNCT
admet-292	41	14	equilibrium	equilibrium	NOUN
admet-292	41	15	)	)	PUNCT
admet-292	41	16	ph	ph	NOUN
admet-292	41	17	of	of	ADP
admet-292	41	18	the	the	DET
admet-292	41	19	saturated	saturate	VERB
admet-292	41	20	solution	solution	NOUN
admet-292	41	21	,	,	PUNCT
admet-292	41	22	phsat	phsat	NOUN
admet-292	41	23	,	,	PUNCT
admet-292	41	24	needs	need	VERB
admet-292	41	25	to	to	PART
admet-292	41	26	be	be	AUX
admet-292	41	27	measured	measure	VERB
admet-292	41	28	directly	directly	ADV
admet-292	41	29	.	.	PUNCT
admet-292	42	1	methods	method	NOUN
admet-292	42	2	of	of	ADP
admet-292	42	3	characterizing	characterize	VERB
admet-292	42	4	the	the	DET
admet-292	42	5	solid	solid	ADJ
admet-292	42	6	state	state	NOUN
admet-292	42	7	(	(	PUNCT
admet-292	42	8	powder	powder	NOUN
admet-292	42	9	x	x	NOUN
admet-292	42	10	-	-	NOUN
admet-292	42	11	ray	ray	NOUN
admet-292	42	12	diffraction	diffraction	NOUN
admet-292	42	13	,	,	PUNCT
admet-292	42	14	differential	differential	NOUN
admet-292	42	15	scanning	scanning	NOUN
admet-292	42	16	calorimetry	calorimetry	NOUN
admet-292	42	17	,	,	PUNCT
admet-292	42	18	ft	ft	PROPN
admet-292	42	19	-	-	PUNCT
admet-292	42	20	ir	ir	NOUN
admet-292	42	21	reflectance	reflectance	NOUN
admet-292	42	22	/	/	SYM
admet-292	42	23	raman	raman	NOUN
admet-292	42	24	spectra	spectra	NOUN
admet-292	42	25	of	of	ADP
admet-292	42	26	slurries	slurry	NOUN
admet-292	42	27	,	,	PUNCT
admet-292	42	28	elemental	elemental	ADJ
admet-292	42	29	analysis	analysis	NOUN
admet-292	42	30	,	,	PUNCT
admet-292	42	31	etc	etc	X
admet-292	42	32	.	.	X
admet-292	42	33	)	)	PUNCT
admet-292	42	34	are	be	AUX
admet-292	42	35	well	well	ADV
admet-292	42	36	established	establish	VERB
admet-292	42	37	.	.	PUNCT
admet-292	43	1	this	this	PRON
admet-292	43	2	is	be	AUX
admet-292	43	3	an	an	DET
admet-292	43	4	important	important	ADJ
admet-292	43	5	consideration	consideration	NOUN
admet-292	43	6	with	with	ADP
admet-292	43	7	actionable	actionable	ADJ
admet-292	43	8	consequences	consequence	NOUN
admet-292	43	9	,	,	PUNCT
admet-292	43	10	since	since	SCONJ
admet-292	43	11	patents	patent	NOUN
admet-292	43	12	may	may	AUX
admet-292	43	13	be	be	AUX
admet-292	43	14	issued	issue	VERB
admet-292	43	15	to	to	PART
admet-292	43	16	cover	cover	VERB
admet-292	43	17	particular	particular	ADJ
admet-292	43	18	solid	solid	ADJ
admet-292	43	19	state	state	NOUN
admet-292	43	20	forms	form	NOUN
admet-292	43	21	of	of	ADP
admet-292	43	22	a	a	DET
admet-292	43	23	marketed	market	VERB
admet-292	43	24	drug	drug	NOUN
admet-292	43	25	substance	substance	NOUN
admet-292	43	26	.	.	PUNCT
admet-292	44	1	however	however	ADV
admet-292	44	2	,	,	PUNCT
admet-292	44	3	characterizations	characterization	NOUN
admet-292	44	4	of	of	ADP
admet-292	44	5	the	the	DET
admet-292	44	6	solution	solution	NOUN
admet-292	44	7	state	state	NOUN
admet-292	44	8	of	of	ADP
admet-292	44	9	ionizable	ionizable	ADJ
admet-292	44	10	substances	substance	NOUN
admet-292	44	11	of	of	ADP
admet-292	44	12	sparingly	sparingly	ADV
admet-292	44	13	-	-	PUNCT
admet-292	44	14	soluble	soluble	ADJ
admet-292	44	15	or	or	CCONJ
admet-292	44	16	amphiphilic	amphiphilic	ADJ
admet-292	44	17	substances	substance	NOUN
admet-292	44	18	that	that	PRON
admet-292	44	19	are	be	AUX
admet-292	44	20	surface	surface	NOUN
admet-292	44	21	active	active	ADJ
admet-292	44	22	are	be	AUX
admet-292	44	23	far	far	ADV
admet-292	44	24	less	less	ADV
admet-292	44	25	well	well	ADV
admet-292	44	26	explored	explore	VERB
admet-292	44	27	.	.	PUNCT
admet-292	45	1	this	this	PRON
admet-292	45	2	is	be	AUX
admet-292	45	3	especially	especially	ADV
admet-292	45	4	true	true	ADJ
admet-292	45	5	of	of	ADP
admet-292	45	6	ionizable	ionizable	ADJ
admet-292	45	7	substances	substance	NOUN
admet-292	45	8	in	in	ADP
admet-292	45	9	saturated	saturate	VERB
admet-292	45	10	solutions	solution	NOUN
admet-292	45	11	above	above	ADP
admet-292	45	12	their	their	PRON
admet-292	45	13	critical	critical	ADJ
admet-292	45	14	micelle	micelle	NOUN
admet-292	45	15	concentration	concentration	NOUN
admet-292	45	16	(	(	PUNCT
admet-292	45	17	cmc	cmc	NOUN
admet-292	45	18	)	)	PUNCT
admet-292	45	19	,	,	PUNCT
admet-292	45	20	with	with	ADP
admet-292	45	21	the	the	DET
admet-292	45	22	assay	assay	NOUN
admet-292	45	23	temperature	temperature	NOUN
admet-292	45	24	being	be	AUX
admet-292	45	25	above	above	ADP
admet-292	45	26	the	the	DET
admet-292	45	27	krafft	krafft	PROPN
admet-292	45	28	point	point	NOUN
admet-292	45	29	[	[	X
admet-292	45	30	5	5	NUM
admet-292	45	31	]	]	PUNCT
admet-292	45	32	.	.	PUNCT
admet-292	46	1	under	under	ADP
admet-292	46	2	such	such	ADJ
admet-292	46	3	circumstances	circumstance	NOUN
admet-292	46	4	,	,	PUNCT
admet-292	46	5	crystalline	crystalline	ADJ
admet-292	46	6	solids	solid	NOUN
admet-292	46	7	of	of	ADP
admet-292	46	8	the	the	DET
admet-292	46	9	substance	substance	NOUN
admet-292	46	10	are	be	AUX
admet-292	46	11	effectively	effectively	ADV
admet-292	46	12	in	in	ADP
admet-292	46	13	equilibrium	equilibrium	NOUN
admet-292	46	14	with	with	ADP
admet-292	46	15	micelles	micelle	NOUN
admet-292	46	16	(	(	PUNCT
admet-292	46	17	or	or	CCONJ
admet-292	46	18	sub	sub	ADJ
admet-292	46	19	-	-	ADJ
admet-292	46	20	micellar	micellar	ADJ
admet-292	46	21	aggregates	aggregate	NOUN
admet-292	46	22	)	)	PUNCT
admet-292	46	23	,	,	PUNCT
admet-292	46	24	in	in	ADP
admet-292	46	25	some	some	DET
admet-292	46	26	cases	case	NOUN
admet-292	46	27	leading	lead	VERB
admet-292	46	28	to	to	ADP
admet-292	46	29	the	the	DET
admet-292	46	30	transient	transient	ADJ
admet-292	46	31	formation	formation	NOUN
admet-292	46	32	of	of	ADP
admet-292	46	33	oils	oil	NOUN
admet-292	46	34	if	if	SCONJ
admet-292	46	35	the	the	DET
admet-292	46	36	melting	melting	NOUN
admet-292	46	37	point	point	NOUN
admet-292	46	38	of	of	ADP
admet-292	46	39	the	the	DET
admet-292	46	40	neutral	neutral	ADJ
admet-292	46	41	form	form	NOUN
admet-292	46	42	of	of	ADP
admet-292	46	43	the	the	DET
admet-292	46	44	substance	substance	NOUN
admet-292	46	45	is	be	AUX
admet-292	46	46	not	not	PART
admet-292	46	47	far	far	ADV
admet-292	46	48	above	above	ADP
admet-292	46	49	the	the	DET
admet-292	46	50	assay	assay	NOUN
admet-292	46	51	temperature	temperature	NOUN
admet-292	46	52	.	.	PUNCT
admet-292	47	1	such	such	ADJ
admet-292	47	2	solutions	solution	NOUN
admet-292	47	3	can	can	AUX
admet-292	47	4	be	be	AUX
admet-292	47	5	very	very	ADV
admet-292	47	6	sensitive	sensitive	ADJ
admet-292	47	7	to	to	ADP
admet-292	47	8	changes	change	NOUN
admet-292	47	9	in	in	ADP
admet-292	47	10	ph	ph	NOUN
admet-292	47	11	and/or	and/or	CCONJ
admet-292	47	12	temperature	temperature	NOUN
admet-292	47	13	,	,	PUNCT
admet-292	47	14	as	as	ADV
admet-292	47	15	well	well	ADV
admet-292	47	16	as	as	ADP
admet-292	47	17	by	by	ADP
admet-292	47	18	the	the	DET
admet-292	47	19	presence	presence	NOUN
admet-292	47	20	of	of	ADP
admet-292	47	21	background	background	NOUN
admet-292	47	22	salts	salt	NOUN
admet-292	47	23	and	and	CCONJ
admet-292	47	24	other	other	ADJ
admet-292	47	25	excipients	excipient	NOUN
admet-292	47	26	[	[	X
admet-292	47	27	6	6	NUM
admet-292	47	28	]	]	PUNCT
admet-292	47	29	.	.	PUNCT
admet-292	48	1	this	this	DET
admet-292	48	2	commentary	commentary	NOUN
admet-292	48	3	is	be	AUX
admet-292	48	4	the	the	DET
admet-292	48	5	outgrowth	outgrowth	NOUN
admet-292	48	6	of	of	ADP
admet-292	48	7	discussions	discussion	NOUN
admet-292	48	8	held	hold	VERB
admet-292	48	9	during	during	ADP
admet-292	48	10	the	the	DET
admet-292	48	11	“	"	PUNCT
admet-292	48	12	thermodynamic	thermodynamic	ADJ
admet-292	48	13	solubility	solubility	NOUN
admet-292	48	14	measurement	measurement	NOUN
admet-292	48	15	of	of	ADP
admet-292	48	16	practically	practically	ADV
admet-292	48	17	insoluble	insoluble	ADJ
admet-292	48	18	ionizable	ionizable	ADJ
admet-292	48	19	drugs	drug	NOUN
admet-292	48	20	–	–	PUNCT
admet-292	48	21	case	case	NOUN
admet-292	48	22	studies	study	NOUN
admet-292	48	23	&	&	CCONJ
admet-292	48	24	suggested	suggest	VERB
admet-292	48	25	method	method	NOUN
admet-292	48	26	improvements	improvement	NOUN
admet-292	48	27	”	"	PUNCT
admet-292	48	28	session	session	NOUN
admet-292	48	29	at	at	ADP
admet-292	48	30	the	the	DET
admet-292	48	31	4th	4th	ADJ
admet-292	48	32	world	world	NOUN
admet-292	48	33	conference	conference	NOUN
admet-292	48	34	on	on	ADP
admet-292	48	35	physico	physico	NOUN
admet-292	48	36	chemical	chemical	NOUN
admet-292	48	37	methods	method	NOUN
admet-292	48	38	in	in	ADP
admet-292	48	39	drug	drug	NOUN
admet-292	48	40	discovery	discovery	NOUN
admet-292	48	41	and	and	CCONJ
admet-292	48	42	development	development	NOUN
admet-292	48	43	(	(	PUNCT
admet-292	48	44	pcmddd-4	pcmddd-4	NOUN
admet-292	48	45	,	,	PUNCT
admet-292	48	46	http://www.iapchem.org/page.php?page_id=56	http://www.iapchem.org/page.php?page_id=56	NOUN
admet-292	48	47	)	)	PUNCT
admet-292	48	48	,	,	PUNCT
admet-292	48	49	held	hold	VERB
admet-292	48	50	on	on	ADP
admet-292	48	51	red	red	ADJ
admet-292	48	52	island	island	PROPN
admet-292	48	53	,	,	PUNCT
admet-292	48	54	croatia	croatia	PROPN
admet-292	48	55	,	,	PUNCT
admet-292	48	56	21	21	NUM
admet-292	48	57	-	-	SYM
admet-292	48	58	24	24	NUM
admet-292	48	59	september	september	PROPN
admet-292	48	60	2015	2015	NUM
admet-292	48	61	.	.	PUNCT
admet-292	49	1	the	the	DET
admet-292	49	2	session	session	NOUN
admet-292	49	3	focused	focus	VERB
admet-292	49	4	on	on	ADP
admet-292	49	5	discussing	discuss	VERB
admet-292	49	6	the	the	DET
admet-292	49	7	best	good	ADJ
admet-292	49	8	practices	practice	NOUN
admet-292	49	9	for	for	ADP
admet-292	49	10	the	the	DET
admet-292	49	11	saturation	saturation	NOUN
admet-292	49	12	shake	shake	NOUN
admet-292	49	13	-	-	PUNCT
admet-292	49	14	flask	flask	NOUN
admet-292	49	15	measurement	measurement	NOUN
admet-292	49	16	of	of	ADP
admet-292	49	17	solubility	solubility	NOUN
admet-292	49	18	as	as	ADP
admet-292	49	19	a	a	DET
admet-292	49	20	function	function	NOUN
admet-292	49	21	of	of	ADP
admet-292	49	22	ph	ph	NOUN
admet-292	49	23	(	(	PUNCT
admet-292	49	24	the	the	DET
admet-292	49	25	“	"	PUNCT
admet-292	49	26	gold	gold	ADJ
admet-292	49	27	standard	standard	NOUN
admet-292	49	28	”	"	PUNCT
admet-292	49	29	methodology	methodology	NOUN
admet-292	49	30	)	)	PUNCT
admet-292	49	31	,	,	PUNCT
admet-292	49	32	along	along	ADP
admet-292	49	33	with	with	ADP
admet-292	49	34	promising	promising	ADJ
admet-292	49	35	potentiometric	potentiometric	ADJ
admet-292	49	36	methods	method	NOUN
admet-292	49	37	,	,	PUNCT
admet-292	49	38	and	and	CCONJ
admet-292	49	39	attempted	attempt	VERB
admet-292	49	40	to	to	PART
admet-292	49	41	reach	reach	VERB
admet-292	49	42	a	a	DET
admet-292	49	43	consensus	consensus	NOUN
admet-292	49	44	about	about	ADP
admet-292	49	45	the	the	DET
admet-292	49	46	best	good	ADJ
admet-292	49	47	approaches	approach	NOUN
admet-292	49	48	for	for	ADP
admet-292	49	49	studying	study	VERB
admet-292	49	50	sparingly	sparingly	ADV
admet-292	49	51	soluble	soluble	ADJ
admet-292	49	52	drug	drug	NOUN
admet-292	49	53	substances	substance	NOUN
admet-292	49	54	.	.	PUNCT
admet-292	50	1	a	a	DET
admet-292	50	2	questionnaire	questionnaire	NOUN
admet-292	50	3	was	be	AUX
admet-292	50	4	prepared	prepare	VERB
admet-292	50	5	and	and	CCONJ
admet-292	50	6	distributed	distribute	VERB
admet-292	50	7	to	to	ADP
admet-292	50	8	the	the	DET
admet-292	50	9	attendees	attendee	NOUN
admet-292	50	10	.	.	PUNCT
admet-292	51	1	the	the	DET
admet-292	51	2	responses	response	NOUN
admet-292	51	3	received	receive	VERB
admet-292	51	4	from	from	ADP
admet-292	51	5	several	several	ADJ
admet-292	51	6	of	of	ADP
admet-292	51	7	the	the	DET
admet-292	51	8	participants	participant	NOUN
admet-292	51	9	are	be	AUX
admet-292	51	10	summarized	summarize	VERB
admet-292	51	11	in	in	ADP
admet-292	51	12	appendix	appendix	PROPN
admet-292	51	13	d.	d.	PROPN
admet-292	51	14	several	several	ADJ
admet-292	51	15	excellent	excellent	ADJ
admet-292	51	16	books	book	NOUN
admet-292	51	17	and	and	CCONJ
admet-292	51	18	reviews	review	NOUN
admet-292	51	19	serve	serve	VERB
admet-292	51	20	as	as	ADP
admet-292	51	21	background	background	NOUN
admet-292	51	22	material	material	NOUN
admet-292	51	23	for	for	ADP
admet-292	51	24	the	the	DET
admet-292	51	25	commentary	commentary	NOUN
admet-292	51	26	covering	cover	VERB
admet-292	51	27	the	the	DET
admet-292	51	28	solubility	solubility	NOUN
admet-292	51	29	of	of	ADP
admet-292	51	30	druglike	druglike	ADJ
admet-292	51	31	molecules	molecule	NOUN
admet-292	51	32	:	:	PUNCT
admet-292	51	33	general	general	ADJ
admet-292	51	34	coverage	coverage	NOUN
admet-292	51	35	of	of	ADP
admet-292	51	36	solubility	solubility	NOUN
admet-292	51	37	[	[	X
admet-292	51	38	7	7	NUM
admet-292	51	39	-	-	SYM
admet-292	51	40	10	10	NUM
admet-292	51	41	]	]	PUNCT
admet-292	51	42	;	;	PUNCT
admet-292	51	43	salt	salt	NOUN
admet-292	51	44	formation	formation	NOUN
admet-292	51	45	/	/	SYM
admet-292	51	46	selection	selection	NOUN
admet-292	51	47	[	[	X
admet-292	51	48	11	11	NUM
admet-292	51	49	-	-	SYM
admet-292	51	50	16	16	NUM
admet-292	51	51	]	]	PUNCT
admet-292	51	52	;	;	PUNCT
admet-292	51	53	polymorphism	polymorphism	NOUN
admet-292	51	54	[	[	X
admet-292	51	55	17	17	NUM
admet-292	51	56	-	-	SYM
admet-292	51	57	20	20	NUM
admet-292	51	58	]	]	PUNCT
admet-292	51	59	;	;	PUNCT
admet-292	51	60	analysis	analysis	NOUN
admet-292	51	61	of	of	ADP
admet-292	51	62	saturated	saturate	VERB
admet-292	51	63	solution	solution	NOUN
admet-292	51	64	speciation	speciation	NOUN
admet-292	52	1	[	[	X
admet-292	52	2	21	21	NUM
admet-292	52	3	-	-	SYM
admet-292	52	4	27	27	NUM
admet-292	52	5	]	]	PUNCT
admet-292	52	6	;	;	PUNCT
admet-292	52	7	dissolution	dissolution	PROPN
admet-292	52	8	/	/	SYM
admet-292	52	9	solubility	solubility	NOUN
admet-292	52	10	of	of	ADP
admet-292	52	11	cocrystals	cocrystal	NOUN
admet-292	52	12	[	[	X
admet-292	52	13	28	28	NUM
admet-292	52	14	-	-	SYM
admet-292	52	15	37	37	NUM
admet-292	52	16	]	]	PUNCT
admet-292	52	17	;	;	PUNCT
admet-292	52	18	anhydrous	anhydrous	ADJ
admet-292	52	19	forms	form	NOUN
admet-292	52	20	versus	versus	ADP
admet-292	52	21	hydrates	hydrate	NOUN
admet-292	52	22	[	[	X
admet-292	52	23	16	16	NUM
admet-292	52	24	,	,	PUNCT
admet-292	52	25	38	38	NUM
admet-292	52	26	,	,	PUNCT
admet-292	52	27	39	39	NUM
admet-292	52	28	]	]	PUNCT
admet-292	52	29	.	.	PUNCT
admet-292	53	1	case	case	NOUN
admet-292	53	2	studies	study	NOUN
admet-292	53	3	the	the	DET
admet-292	53	4	commentary	commentary	NOUN
admet-292	53	5	begins	begin	VERB
admet-292	53	6	with	with	ADP
admet-292	53	7	several	several	ADJ
admet-292	53	8	selected	select	VERB
admet-292	53	9	case	case	NOUN
admet-292	53	10	studies	study	NOUN
admet-292	53	11	of	of	ADP
admet-292	53	12	molecules	molecule	NOUN
admet-292	53	13	which	which	PRON
admet-292	53	14	illustrate	illustrate	VERB
admet-292	53	15	appreciable	appreciable	ADJ
admet-292	53	16	challenges	challenge	NOUN
admet-292	53	17	encountered	encounter	VERB
admet-292	53	18	in	in	ADP
admet-292	53	19	the	the	DET
admet-292	53	20	measurement	measurement	NOUN
admet-292	53	21	of	of	ADP
admet-292	53	22	solubility	solubility	PROPN
admet-292	53	23	.	.	PUNCT
admet-292	54	1	figure	figure	NOUN
admet-292	54	2	1	1	NUM
admet-292	54	3	shows	show	VERB
admet-292	54	4	four	four	NUM
admet-292	54	5	examples	example	NOUN
admet-292	54	6	of	of	ADP
admet-292	54	7	drugs	drug	NOUN
admet-292	54	8	which	which	PRON
admet-292	54	9	reveal	reveal	VERB
admet-292	54	10	relatively	relatively	ADV
admet-292	54	11	simple	simple	ADJ
admet-292	54	12	logs	log	NOUN
admet-292	54	13	-	-	PUNCT
admet-292	54	14	ph	ph	ADJ
admet-292	54	15	profiles	profile	NOUN
admet-292	54	16	,	,	PUNCT
admet-292	54	17	which	which	PRON
admet-292	54	18	can	can	AUX
admet-292	54	19	be	be	AUX
admet-292	54	20	more	more	ADV
admet-292	54	21	or	or	CCONJ
admet-292	54	22	less	less	ADV
admet-292	54	23	predicted	predict	VERB
admet-292	54	24	by	by	ADP
admet-292	54	25	the	the	DET
admet-292	54	26	henderson	henderson	PROPN
admet-292	54	27	-	-	PUNCT
admet-292	54	28	hasselbalch	hasselbalch	PROPN
admet-292	54	29	(	(	PUNCT
admet-292	54	30	hh	hh	NOUN
admet-292	54	31	)	)	PUNCT
admet-292	54	32	equation	equation	NOUN
admet-292	54	33	[	[	X
admet-292	54	34	27	27	NUM
admet-292	54	35	,	,	PUNCT
admet-292	54	36	40	40	NUM
admet-292	54	37	,	,	PUNCT
admet-292	54	38	41	41	NUM
admet-292	54	39	]	]	PUNCT
admet-292	54	40	.	.	PUNCT
admet-292	55	1	figure	figure	NOUN
admet-292	55	2	2	2	NUM
admet-292	55	3	shows	show	VERB
admet-292	55	4	three	three	NUM
admet-292	55	5	examples	example	NOUN
admet-292	55	6	of	of	ADP
admet-292	55	7	molecules	molecule	NOUN
admet-292	55	8	with	with	ADP
admet-292	55	9	logs	log	NOUN
admet-292	55	10	-	-	PUNCT
admet-292	55	11	ph	ph	ADJ
admet-292	55	12	profiles	profile	NOUN
admet-292	55	13	that	that	PRON
admet-292	55	14	are	be	AUX
admet-292	55	15	consistent	consistent	ADJ
admet-292	55	16	with	with	ADP
admet-292	55	17	the	the	DET
admet-292	55	18	presence	presence	NOUN
admet-292	55	19	of	of	ADP
admet-292	55	20	anionic	anionic	ADJ
admet-292	55	21	or	or	CCONJ
admet-292	55	22	uncharged	uncharged	ADJ
admet-292	55	23	self	self	NOUN
admet-292	55	24	-	-	PUNCT
admet-292	55	25	associated	associate	VERB
admet-292	55	26	aggregates	aggregate	NOUN
admet-292	55	27	,	,	PUNCT
admet-292	55	28	and	and	CCONJ
admet-292	55	29	one	one	NUM
admet-292	55	30	case	case	NOUN
admet-292	55	31	consistent	consistent	ADJ
admet-292	55	32	with	with	ADP
admet-292	55	33	drugbuffer	drugbuffer	NOUN
admet-292	55	34	interaction	interaction	NOUN
admet-292	55	35	.	.	PUNCT
admet-292	56	1	figure	figure	NOUN
admet-292	56	2	3	3	NUM
admet-292	56	3	illustrates	illustrate	VERB
admet-292	56	4	the	the	DET
admet-292	56	5	logs	log	NOUN
admet-292	56	6	-	-	PUNCT
admet-292	56	7	ph	ph	ADJ
admet-292	56	8	profiles	profile	NOUN
admet-292	56	9	of	of	ADP
admet-292	56	10	haloperidol	haloperidol	NOUN
admet-292	56	11	resulting	result	VERB
admet-292	56	12	from	from	ADP
admet-292	56	13	different	different	ADJ
admet-292	56	14	salt	salt	NOUN
admet-292	56	15	precipitations	precipitation	NOUN
admet-292	56	16	,	,	PUNCT
admet-292	56	17	illustrating	illustrate	VERB
admet-292	56	18	some	some	DET
admet-292	56	19	degree	degree	NOUN
admet-292	56	20	of	of	ADP
admet-292	56	21	supersaturation	supersaturation	NOUN
admet-292	56	22	for	for	ADP
admet-292	56	23	two	two	NUM
admet-292	56	24	cases	case	NOUN
admet-292	56	25	near	near	ADP
admet-292	56	26	the	the	DET
admet-292	56	27	gibbs	gibbs	PROPN
admet-292	56	28	pka	pka	PROPN
admet-292	57	1	[	[	X
admet-292	57	2	42	42	NUM
admet-292	57	3	,	,	PUNCT
admet-292	57	4	43	43	NUM
admet-292	57	5	]	]	PUNCT
admet-292	57	6	in	in	ADP
admet-292	57	7	the	the	DET
admet-292	57	8	ph	ph	ADJ
admet-292	57	9	4.1	4.1	NUM
admet-292	57	10	-	-	SYM
admet-292	57	11	4.9	4.9	NUM
admet-292	57	12	interval	interval	NOUN
admet-292	57	13	and	and	CCONJ
admet-292	57	14	the	the	DET
admet-292	57	15	possible	possible	ADJ
admet-292	57	16	formation	formation	NOUN
admet-292	57	17	of	of	ADP
admet-292	57	18	uncharged	uncharged	ADJ
admet-292	57	19	aggregates	aggregate	NOUN
admet-292	57	20	for	for	ADP
admet-292	57	21	ph>8	ph>8	PROPN
admet-292	57	22	.	.	PUNCT
admet-292	57	23	figures	figure	NOUN
admet-292	57	24	4	4	NUM
admet-292	57	25	and	and	CCONJ
admet-292	57	26	5	5	NUM
admet-292	57	27	ratchet	ratchet	NOUN
admet-292	57	28	up	up	ADP
admet-292	57	29	the	the	DET
admet-292	57	30	complexity	complexity	NOUN
admet-292	57	31	of	of	ADP
admet-292	57	32	logs	log	NOUN
admet-292	57	33	-	-	PUNCT
admet-292	57	34	ph	ph	ADJ
admet-292	57	35	profiles	profile	NOUN
admet-292	57	36	of	of	ADP
admet-292	57	37	surface	surface	NOUN
admet-292	57	38	-	-	PUNCT
admet-292	57	39	active	active	ADJ
admet-292	57	40	molecules	molecule	NOUN
admet-292	57	41	which	which	PRON
admet-292	57	42	precipitate	precipitate	VERB
admet-292	57	43	both	both	PRON
admet-292	57	44	as	as	ADP
admet-292	57	45	salts	salt	NOUN
admet-292	57	46	and	and	CCONJ
admet-292	57	47	as	as	ADP
admet-292	57	48	uncharged	uncharged	ADJ
admet-292	57	49	species	specie	NOUN
admet-292	57	50	.	.	PUNCT
admet-292	58	1	the	the	DET
admet-292	58	2	examples	example	NOUN
admet-292	58	3	were	be	AUX
admet-292	58	4	selected	select	VERB
admet-292	58	5	to	to	PART
admet-292	58	6	show	show	VERB
admet-292	58	7	that	that	PRON
admet-292	58	8	care	care	NOUN
admet-292	58	9	needs	need	VERB
admet-292	58	10	to	to	PART
admet-292	58	11	be	be	AUX
admet-292	58	12	exercised	exercise	VERB
admet-292	58	13	in	in	ADP
admet-292	58	14	interpreting	interpret	VERB
admet-292	58	15	the	the	DET
admet-292	58	16	shapes	shape	NOUN
admet-292	58	17	of	of	ADP
admet-292	58	18	the	the	DET
admet-292	58	19	solubility	solubility	NOUN
admet-292	58	20	-	-	PUNCT
admet-292	58	21	ph	ph	VERB
admet-292	58	22	http://www.iapchem.org/page.php?page_id=56	http://www.iapchem.org/page.php?page_id=56	NOUN
admet-292	58	23	alex	alex	PROPN
admet-292	58	24	avdeef	avdeef	PROPN
admet-292	58	25	et	et	PROPN
admet-292	58	26	al	al	PROPN
admet-292	58	27	.	.	PROPN
admet-292	58	28	admet	admet	PROPN
admet-292	58	29	&	&	CCONJ
admet-292	58	30	dmpk	dmpk	PROPN
admet-292	58	31	4(2	4(2	NUM
admet-292	58	32	)	)	PUNCT
admet-292	58	33	(	(	PUNCT
admet-292	58	34	2016	2016	NUM
admet-292	58	35	)	)	PUNCT
admet-292	58	36	117	117	NUM
admet-292	58	37	-	-	SYM
admet-292	58	38	178	178	NUM
admet-292	58	39	120	120	NUM
admet-292	58	40	profiles	profile	NOUN
admet-292	58	41	[	[	X
admet-292	58	42	21	21	NUM
admet-292	58	43	-	-	SYM
admet-292	58	44	25	25	NUM
admet-292	58	45	]	]	PUNCT
admet-292	58	46	and	and	CCONJ
admet-292	58	47	that	that	SCONJ
admet-292	58	48	assays	assay	NOUN
admet-292	58	49	need	need	VERB
admet-292	58	50	to	to	PART
admet-292	58	51	be	be	AUX
admet-292	58	52	optimized	optimize	VERB
admet-292	58	53	to	to	PART
admet-292	58	54	enhance	enhance	VERB
admet-292	58	55	the	the	DET
admet-292	58	56	confidence	confidence	NOUN
admet-292	58	57	in	in	ADP
admet-292	58	58	the	the	DET
admet-292	58	59	interpretations	interpretation	NOUN
admet-292	58	60	of	of	ADP
admet-292	58	61	the	the	DET
admet-292	58	62	data	datum	NOUN
admet-292	58	63	.	.	PUNCT
admet-292	59	1	figure	figure	NOUN
admet-292	59	2	1	1	NUM
admet-292	59	3	.	.	PUNCT
admet-292	59	4	four	four	NUM
admet-292	59	5	examples	example	NOUN
admet-292	59	6	of	of	ADP
admet-292	59	7	drugs	drug	NOUN
admet-292	59	8	which	which	PRON
admet-292	59	9	reveal	reveal	VERB
admet-292	59	10	relatively	relatively	ADV
admet-292	59	11	simple	simple	ADJ
admet-292	59	12	logs	log	NOUN
admet-292	59	13	-	-	PUNCT
admet-292	59	14	ph	ph	ADJ
admet-292	59	15	profiles	profile	NOUN
admet-292	59	16	,	,	PUNCT
admet-292	59	17	which	which	PRON
admet-292	59	18	can	can	AUX
admet-292	59	19	be	be	AUX
admet-292	59	20	more	more	ADV
admet-292	59	21	or	or	CCONJ
admet-292	59	22	less	less	ADV
admet-292	59	23	predicted	predict	VERB
admet-292	59	24	by	by	ADP
admet-292	59	25	the	the	DET
admet-292	59	26	henderson	henderson	PROPN
admet-292	59	27	-	-	PUNCT
admet-292	59	28	hasselbalch	hasselbalch	PROPN
admet-292	59	29	equation	equation	NOUN
admet-292	59	30	.	.	PUNCT
admet-292	60	1	the	the	DET
admet-292	60	2	following	follow	VERB
admet-292	60	3	logs	log	NOUN
admet-292	60	4	-	-	PUNCT
admet-292	60	5	ph	ph	ADJ
admet-292	60	6	curve	curve	NOUN
admet-292	60	7	notations	notation	NOUN
admet-292	60	8	are	be	AUX
admet-292	60	9	used	use	VERB
admet-292	60	10	(	(	PUNCT
admet-292	60	11	except	except	SCONJ
admet-292	60	12	figures	figure	VERB
admet-292	60	13	4b	4b	PROPN
admet-292	60	14	and	and	CCONJ
admet-292	60	15	5b	5b	NUM
admet-292	60	16	):	):	PUNCT
admet-292	60	17			NOUN
admet-292	60	18	the	the	DET
admet-292	60	19	dashed	dash	VERB
admet-292	60	20	curves	curve	NOUN
admet-292	60	21	refer	refer	VERB
admet-292	60	22	to	to	ADP
admet-292	60	23	the	the	DET
admet-292	60	24	profiles	profile	NOUN
admet-292	60	25	calculated	calculate	VERB
admet-292	60	26	from	from	ADP
admet-292	60	27	the	the	DET
admet-292	60	28	simple	simple	ADJ
admet-292	60	29	hh	hh	NOUN
admet-292	60	30	equation	equation	NOUN
admet-292	60	31	(	(	PUNCT
admet-292	60	32	not	not	PART
admet-292	60	33	corrected	correct	VERB
admet-292	60	34	for	for	ADP
admet-292	60	35	ionic	ionic	ADJ
admet-292	60	36	strength	strength	NOUN
admet-292	60	37	or	or	CCONJ
admet-292	60	38	dilution	dilution	NOUN
admet-292	60	39	effects	effect	NOUN
admet-292	60	40	)	)	PUNCT
admet-292	60	41			PRON
admet-292	61	1	the	the	DET
admet-292	61	2	solid	solid	ADJ
admet-292	61	3	curves	curve	NOUN
admet-292	61	4	are	be	AUX
admet-292	61	5	calculated	calculate	VERB
admet-292	61	6	using	use	VERB
admet-292	61	7	the	the	DET
admet-292	61	8	refined	refined	ADJ
admet-292	61	9	constants	constant	NOUN
admet-292	61	10	from	from	ADP
admet-292	61	11	fitting	fit	VERB
admet-292	61	12	the	the	DET
admet-292	61	13	measured	measure	VERB
admet-292	61	14	logs	log	NOUN
admet-292	61	15	-	-	PUNCT
admet-292	61	16	ph	ph	ADJ
admet-292	61	17	data	datum	NOUN
admet-292	61	18	(	(	PUNCT
admet-292	61	19	filled	fill	VERB
admet-292	61	20	circles	circle	NOUN
admet-292	61	21	)	)	PUNCT
admet-292	61	22	to	to	ADP
admet-292	61	23	the	the	DET
admet-292	61	24	proposed	propose	VERB
admet-292	61	25	equilibrium	equilibrium	NOUN
admet-292	61	26	model	model	NOUN
admet-292	61	27	,	,	PUNCT
admet-292	61	28	using	use	VERB
admet-292	61	29	the	the	DET
admet-292	61	30	pdisol	pdisol	ADJ
admet-292	61	31	-	-	PUNCT
admet-292	61	32	x	x	NOUN
admet-292	61	33	program	program	NOUN
admet-292	61	34	(	(	PUNCT
admet-292	61	35	in	in	ADP
admet-292	61	36	-	-	PUNCT
admet-292	61	37	adme	adme	NOUN
admet-292	61	38	research	research	NOUN
admet-292	61	39	;	;	PUNCT
admet-292	61	40	www.in-adme.com/pdisol_x.html	www.in-adme.com/pdisol_x.html	PROPN
admet-292	61	41	)	)	PUNCT
admet-292	61	42			NOUN
admet-292	62	1	the	the	DET
admet-292	62	2	dotted	dotted	ADJ
admet-292	62	3	curves	curve	NOUN
admet-292	62	4	indicate	indicate	VERB
admet-292	62	5	regions	region	NOUN
admet-292	62	6	of	of	ADP
admet-292	62	7	ph	ph	NOUN
admet-292	62	8	of	of	ADP
admet-292	62	9	subsaturation	subsaturation	NOUN
admet-292	62	10	,	,	PUNCT
admet-292	62	11	where	where	SCONJ
admet-292	62	12	the	the	DET
admet-292	62	13	substances	substance	NOUN
admet-292	62	14	are	be	AUX
admet-292	62	15	dissolved	dissolve	VERB
admet-292	62	16			NOUN
admet-292	62	17	s0	s0	PROPN
admet-292	62	18	refers	refer	VERB
admet-292	62	19	to	to	ADP
admet-292	62	20	the	the	DET
admet-292	62	21	intrinsic	intrinsic	ADJ
admet-292	62	22	solubility	solubility	NOUN
admet-292	62	23	of	of	ADP
admet-292	62	24	the	the	DET
admet-292	62	25	uncharged	uncharged	ADJ
admet-292	62	26	form	form	NOUN
admet-292	62	27	of	of	ADP
admet-292	62	28	the	the	DET
admet-292	62	29	substance	substance	NOUN
admet-292	62	30			PRON
admet-292	62	31	pksp	pksp	PROPN
admet-292	62	32	refers	refer	VERB
admet-292	62	33	to	to	ADP
admet-292	62	34	the	the	DET
admet-292	62	35	negative	negative	ADJ
admet-292	62	36	log	log	NOUN
admet-292	62	37	of	of	ADP
admet-292	62	38	the	the	DET
admet-292	62	39	salt	salt	NOUN
admet-292	62	40	(	(	PUNCT
admet-292	62	41	or	or	CCONJ
admet-292	62	42	cocrystal	cocrystal	ADJ
admet-292	62	43	,	,	PUNCT
admet-292	62	44	as	as	ADP
admet-292	62	45	in	in	ADP
admet-292	62	46	later	late	ADJ
admet-292	62	47	sections	section	NOUN
admet-292	62	48	)	)	PUNCT
admet-292	62	49	solubility	solubility	NOUN
admet-292	62	50	product	product	NOUN
admet-292	62	51			NOUN
admet-292	62	52	the	the	DET
admet-292	62	53	reference	reference	NOUN
admet-292	62	54	and	and	CCONJ
admet-292	62	55	average	average	ADJ
admet-292	62	56	ionic	ionic	ADJ
admet-292	62	57	strengths	strength	NOUN
admet-292	62	58	are	be	AUX
admet-292	62	59	indicated	indicate	VERB
admet-292	62	60	as	as	ADP
admet-292	62	61	iref	iref	NOUN
admet-292	62	62	and	and	CCONJ
admet-292	62	63	iavg	iavg	PROPN
admet-292	62	64	,	,	PUNCT
admet-292	62	65	respectively	respectively	ADV
admet-292	62	66	.	.	PUNCT
admet-292	63	1	the	the	DET
admet-292	63	2	former	former	ADJ
admet-292	63	3	values	value	NOUN
admet-292	63	4	correspond	correspond	VERB
admet-292	63	5	to	to	ADP
admet-292	63	6	the	the	DET
admet-292	63	7	pka	pka	PROPN
admet-292	63	8	determination	determination	NOUN
admet-292	63	9	conditions	condition	NOUN
admet-292	63	10	.	.	PUNCT
admet-292	64	1	corrections	correction	NOUN
admet-292	64	2	are	be	AUX
admet-292	64	3	made	make	VERB
admet-292	64	4	for	for	ADP
admet-292	64	5	changes	change	NOUN
admet-292	64	6	in	in	ADP
admet-292	64	7	the	the	DET
admet-292	64	8	ionic	ionic	ADJ
admet-292	64	9	strength	strength	NOUN
admet-292	64	10	in	in	ADP
admet-292	64	11	the	the	DET
admet-292	64	12	solubility	solubility	NOUN
admet-292	64	13	assays	assay	NOUN
admet-292	64	14	,	,	PUNCT
admet-292	64	15	as	as	SCONJ
admet-292	64	16	described	describe	VERB
admet-292	64	17	by	by	ADP
admet-292	64	18	völgyi	völgyi	PROPN
admet-292	64	19	et	et	PROPN
admet-292	64	20	al	al	PROPN
admet-292	64	21	.	.	PUNCT
admet-292	65	1	[	[	X
admet-292	65	2	22	22	NUM
admet-292	65	3	]	]	PUNCT
admet-292	65	4	and	and	CCONJ
admet-292	65	5	wang	wang	PROPN
admet-292	65	6	et	et	PROPN
admet-292	65	7	al	al	PROPN
admet-292	65	8	.	.	PUNCT
admet-292	66	1	[	[	X
admet-292	66	2	44	44	NUM
admet-292	66	3	]	]	PUNCT
admet-292	66	4			NOUN
admet-292	66	5	the	the	DET
admet-292	66	6	jh	jh	PROPN
admet-292	66	7	coefficients	coefficient	NOUN
admet-292	66	8	(	(	PUNCT
admet-292	66	9	figure	figure	NOUN
admet-292	66	10	3b	3b	NUM
admet-292	66	11	,	,	PUNCT
admet-292	66	12	c	c	X
admet-292	66	13	,	,	PUNCT
admet-292	66	14	d	d	NOUN
admet-292	66	15	)	)	PUNCT
admet-292	66	16	refer	refer	VERB
admet-292	66	17	to	to	ADP
admet-292	66	18	estimated	estimate	VERB
admet-292	66	19	ph	ph	ADJ
admet-292	66	20	electrode	electrode	NOUN
admet-292	66	21	junction	junction	NOUN
admet-292	66	22	potential	potential	ADJ
admet-292	66	23	factors	factor	NOUN
admet-292	66	24	[	[	X
admet-292	66	25	45	45	NUM
admet-292	66	26	]	]	PUNCT
admet-292	66	27	in	in	ADP
admet-292	66	28	very	very	ADV
admet-292	66	29	acidic	acidic	ADJ
admet-292	66	30	solutions	solution	NOUN
admet-292	66	31	(	(	PUNCT
admet-292	66	32	ph	ph	X
admet-292	66	33	<	<	X
admet-292	66	34	1	1	NUM
admet-292	66	35	)	)	PUNCT
admet-292	66	36	,	,	PUNCT
admet-292	66	37	as	as	SCONJ
admet-292	66	38	detailed	detail	VERB
admet-292	66	39	in	in	ADP
admet-292	66	40	appendix	appendix	ADJ
admet-292	66	41	c.	c.	PROPN
admet-292	66	42	http://www.in-adme.com/pdisol_x.html	http://www.in-adme.com/pdisol_x.html	PROPN
admet-292	66	43	admet	admet	PROPN
admet-292	66	44	&	&	CCONJ
admet-292	66	45	dmpk	dmpk	PROPN
admet-292	66	46	4(2	4(2	NUM
admet-292	66	47	)	)	PUNCT
admet-292	66	48	(	(	PUNCT
admet-292	66	49	2016	2016	NUM
admet-292	66	50	)	)	PUNCT
admet-292	66	51	117	117	NUM
admet-292	66	52	-	-	SYM
admet-292	66	53	178	178	NUM
admet-292	66	54	consensus	consensus	NOUN
admet-292	66	55	recommendations	recommendation	NOUN
admet-292	66	56	for	for	ADP
admet-292	66	57	improving	improve	VERB
admet-292	66	58	solubility	solubility	NOUN
admet-292	66	59	-	-	PUNCT
admet-292	66	60	ph	ph	ADJ
admet-292	66	61	data	datum	NOUN
admet-292	66	62	quality	quality	NOUN
admet-292	66	63	doi	doi	NOUN
admet-292	66	64	:	:	PUNCT
admet-292	66	65	10.5599	10.5599	NUM
admet-292	66	66	/	/	SYM
admet-292	66	67	admet.4.2.292	admet.4.2.292	NUM
admet-292	66	68	121	121	NUM
admet-292	66	69	atenolol	atenolol	NOUN
admet-292	66	70	figure	figure	NOUN
admet-292	66	71	1a	1a	PROPN
admet-292	66	72	shows	show	VERB
admet-292	66	73	the	the	DET
admet-292	66	74	logs	log	NOUN
admet-292	66	75	-	-	PUNCT
admet-292	66	76	ph	ph	NOUN
admet-292	66	77	profile	profile	NOUN
admet-292	66	78	of	of	ADP
admet-292	66	79	atenolol	atenolol	PROPN
admet-292	67	1	[	[	X
admet-292	67	2	46	46	NUM
admet-292	67	3	]	]	PUNCT
admet-292	67	4	.	.	PUNCT
admet-292	68	1	since	since	SCONJ
admet-292	68	2	the	the	DET
admet-292	68	3	weak	weak	ADJ
admet-292	68	4	base	base	NOUN
admet-292	68	5	is	be	AUX
admet-292	68	6	relatively	relatively	ADV
admet-292	68	7	soluble	soluble	ADJ
admet-292	68	8	,	,	PUNCT
admet-292	68	9	it	it	PRON
admet-292	68	10	takes	take	VERB
admet-292	68	11	a	a	DET
admet-292	68	12	3.8	3.8	NUM
admet-292	68	13	m	m	NOUN
admet-292	68	14	atenolol	atenolol	NOUN
admet-292	68	15	solution	solution	NOUN
admet-292	68	16	(	(	PUNCT
admet-292	68	17	1	1	NUM
admet-292	68	18	g	g	NOUN
admet-292	68	19	of	of	ADP
admet-292	68	20	the	the	DET
admet-292	68	21	free	free	ADJ
admet-292	68	22	base	base	NOUN
admet-292	68	23	added	add	VERB
admet-292	68	24	to	to	ADP
admet-292	68	25	1	1	NUM
admet-292	68	26	ml	ml	NOUN
admet-292	68	27	of	of	ADP
admet-292	68	28	50	50	NUM
admet-292	68	29	mm	mm	NOUN
admet-292	68	30	phosphate	phosphate	NOUN
admet-292	68	31	buffer	buffer	NOUN
admet-292	68	32	)	)	PUNCT
admet-292	68	33	to	to	PART
admet-292	68	34	span	span	VERB
admet-292	68	35	the	the	DET
admet-292	68	36	concentration	concentration	NOUN
admet-292	68	37	range	range	NOUN
admet-292	68	38	shown	show	VERB
admet-292	68	39	in	in	ADP
admet-292	68	40	the	the	DET
admet-292	68	41	figure	figure	NOUN
admet-292	68	42	.	.	PUNCT
admet-292	69	1	the	the	DET
admet-292	69	2	ionic	ionic	ADJ
admet-292	69	3	strength	strength	NOUN
admet-292	69	4	rises	rise	VERB
admet-292	69	5	from	from	ADP
admet-292	69	6	0.24	0.24	NUM
admet-292	69	7	to	to	ADP
admet-292	69	8	0.83	0.83	NUM
admet-292	69	9	m	m	NOUN
admet-292	69	10	as	as	SCONJ
admet-292	69	11	ph	ph	NOUN
admet-292	69	12	is	be	AUX
admet-292	69	13	lowered	lower	VERB
admet-292	69	14	from	from	ADP
admet-292	69	15	9.5	9.5	NUM
admet-292	69	16	to	to	ADP
admet-292	69	17	8.5	8.5	NUM
admet-292	69	18	using	use	VERB
admet-292	69	19	1	1	NUM
admet-292	69	20	m	m	NOUN
admet-292	69	21	hcl	hcl	PROPN
admet-292	69	22	.	.	PUNCT
admet-292	70	1	such	such	ADJ
admet-292	70	2	ph	ph	ADJ
admet-292	70	3	adjustment	adjustment	NOUN
admet-292	70	4	is	be	AUX
admet-292	70	5	accompanied	accompany	VERB
admet-292	70	6	by	by	ADP
admet-292	70	7	a	a	DET
admet-292	70	8	very	very	ADV
admet-292	70	9	large	large	ADJ
admet-292	70	10	dilution	dilution	NOUN
admet-292	70	11	effect	effect	NOUN
admet-292	70	12	.	.	PUNCT
admet-292	71	1	this	this	PRON
admet-292	71	2	requires	require	VERB
admet-292	71	3	that	that	SCONJ
admet-292	71	4	the	the	DET
admet-292	71	5	ph	ph	ADJ
admet-292	71	6	electrode	electrode	NOUN
admet-292	71	7	used	use	VERB
admet-292	71	8	be	be	AUX
admet-292	71	9	well	well	ADV
admet-292	71	10	-	-	PUNCT
admet-292	71	11	calibrated	calibrate	VERB
admet-292	71	12	.	.	PUNCT
admet-292	72	1	since	since	SCONJ
admet-292	72	2	the	the	DET
admet-292	72	3	accurate	accurate	ADJ
admet-292	72	4	pka	pka	PROPN
admet-292	72	5	of	of	ADP
admet-292	72	6	atenolol	atenolol	PROPN
admet-292	72	7	is	be	AUX
admet-292	72	8	known	know	VERB
admet-292	72	9	,	,	PUNCT
admet-292	72	10	the	the	DET
admet-292	72	11	fit	fit	NOUN
admet-292	72	12	can	can	AUX
admet-292	72	13	be	be	AUX
admet-292	72	14	further	far	ADV
admet-292	72	15	improved	improve	VERB
admet-292	72	16	over	over	ADP
admet-292	72	17	what	what	PRON
admet-292	72	18	is	be	AUX
admet-292	72	19	shown	show	VERB
admet-292	72	20	,	,	PUNCT
admet-292	72	21	by	by	ADP
admet-292	72	22	assuming	assume	VERB
admet-292	72	23	the	the	DET
admet-292	72	24	presence	presence	NOUN
admet-292	72	25	of	of	ADP
admet-292	72	26	a	a	DET
admet-292	72	27	neutral	neutral	ADJ
admet-292	72	28	aggregate	aggregate	ADJ
admet-292	72	29	species	specie	NOUN
admet-292	72	30	,	,	PUNCT
admet-292	72	31	(	(	PUNCT
admet-292	72	32	case	case	NOUN
admet-292	72	33	1b	1b	NUM
admet-292	72	34	in	in	ADP
admet-292	72	35	[	[	X
admet-292	72	36	27	27	NUM
admet-292	72	37	]	]	NUM
admet-292	72	38	)	)	PUNCT
admet-292	72	39	;	;	PUNCT
admet-292	72	40	the	the	DET
admet-292	72	41	standard	standard	ADJ
admet-292	72	42	deviation	deviation	NOUN
admet-292	72	43	drops	drop	VERB
admet-292	72	44	from	from	ADP
admet-292	72	45	0.047	0.047	NUM
admet-292	72	46	to	to	ADP
admet-292	72	47	0.015	0.015	NUM
admet-292	72	48	log	log	NOUN
admet-292	72	49	unit	unit	NOUN
admet-292	72	50	.	.	PUNCT
admet-292	73	1	the	the	DET
admet-292	73	2	intrinsic	intrinsic	ADJ
admet-292	73	3	solubility	solubility	NOUN
admet-292	73	4	is	be	AUX
admet-292	73	5	slightly	slightly	ADV
admet-292	73	6	lessened	lessen	VERB
admet-292	73	7	from	from	ADP
admet-292	73	8	14.1	14.1	NUM
admet-292	73	9	to	to	PART
admet-292	73	10	11.0	11.0	NUM
admet-292	73	11	mg	mg	NUM
admet-292	73	12	/	/	SYM
admet-292	73	13	ml	ml	NOUN
admet-292	73	14	.	.	PUNCT
admet-292	74	1	the	the	DET
admet-292	74	2	performance	performance	NOUN
admet-292	74	3	of	of	ADP
admet-292	74	4	the	the	DET
admet-292	74	5	ph	ph	ADJ
admet-292	74	6	electrode	electrode	NOUN
admet-292	74	7	is	be	AUX
admet-292	74	8	quite	quite	ADV
admet-292	74	9	important	important	ADJ
admet-292	74	10	in	in	ADP
admet-292	74	11	this	this	DET
admet-292	74	12	case	case	NOUN
admet-292	74	13	study	study	NOUN
admet-292	74	14	.	.	PUNCT
admet-292	75	1	atorvastatin	atorvastatin	PROPN
admet-292	75	2	figure	figure	PROPN
admet-292	75	3	1b	1b	PROPN
admet-292	75	4	shows	show	VERB
admet-292	75	5	the	the	DET
admet-292	75	6	logs	log	NOUN
admet-292	75	7	-	-	PUNCT
admet-292	75	8	ph	ph	ADJ
admet-292	75	9	profile	profile	NOUN
admet-292	75	10	of	of	ADP
admet-292	75	11	atorvastatin	atorvastatin	PROPN
admet-292	75	12	added	add	VERB
admet-292	75	13	as	as	ADP
admet-292	75	14	the	the	DET
admet-292	75	15	calcium	calcium	NOUN
admet-292	75	16	salt	salt	NOUN
admet-292	76	1	[	[	X
admet-292	76	2	47	47	NUM
admet-292	76	3	]	]	PUNCT
admet-292	76	4	.	.	PUNCT
admet-292	77	1	this	this	DET
admet-292	77	2	example	example	NOUN
admet-292	77	3	illustrates	illustrate	VERB
admet-292	77	4	the	the	DET
admet-292	77	5	need	need	NOUN
admet-292	77	6	to	to	PART
admet-292	77	7	know	know	VERB
admet-292	77	8	the	the	DET
admet-292	77	9	pka	pka	NOUN
admet-292	77	10	accurately	accurately	ADV
admet-292	77	11	.	.	PUNCT
admet-292	78	1	the	the	DET
admet-292	78	2	value	value	NOUN
admet-292	78	3	of	of	ADP
admet-292	78	4	4.37	4.37	NUM
admet-292	78	5	at	at	ADP
admet-292	78	6	37	37	NUM
admet-292	78	7	o	o	NOUN
admet-292	78	8	c	c	NOUN
admet-292	78	9	was	be	AUX
admet-292	78	10	predicted	predict	VERB
admet-292	78	11	[	[	X
admet-292	78	12	26	26	NUM
admet-292	78	13	]	]	PUNCT
admet-292	78	14	from	from	ADP
admet-292	78	15	the	the	DET
admet-292	78	16	measured	measure	VERB
admet-292	78	17	value	value	NOUN
admet-292	78	18	at	at	ADP
admet-292	78	19	25	25	NUM
admet-292	78	20	o	o	NOUN
admet-292	78	21	c	c	NOUN
admet-292	79	1	[	[	X
admet-292	79	2	48	48	NUM
admet-292	79	3	]	]	PUNCT
admet-292	79	4	.	.	PUNCT
admet-292	80	1	if	if	SCONJ
admet-292	80	2	4.37	4.37	NUM
admet-292	80	3	is	be	AUX
admet-292	80	4	the	the	DET
admet-292	80	5	correct	correct	ADJ
admet-292	80	6	value	value	NOUN
admet-292	80	7	,	,	PUNCT
admet-292	80	8	then	then	ADV
admet-292	80	9	the	the	DET
admet-292	80	10	small	small	ADJ
admet-292	80	11	parallel	parallel	ADJ
admet-292	80	12	displacement	displacement	NOUN
admet-292	80	13	of	of	ADP
admet-292	80	14	the	the	DET
admet-292	80	15	solubility	solubility	NOUN
admet-292	80	16	values	value	NOUN
admet-292	80	17	in	in	ADP
admet-292	80	18	the	the	DET
admet-292	80	19	ph	ph	ADJ
admet-292	80	20	4	4	NUM
admet-292	80	21	-	-	SYM
admet-292	80	22	5	5	NUM
admet-292	80	23	region	region	NOUN
admet-292	80	24	to	to	ADP
admet-292	80	25	lower	low	ADJ
admet-292	80	26	ph	ph	NOUN
admet-292	80	27	is	be	AUX
admet-292	80	28	consistent	consistent	ADJ
admet-292	80	29	with	with	ADP
admet-292	80	30	the	the	DET
admet-292	80	31	presence	presence	NOUN
admet-292	80	32	of	of	ADP
admet-292	80	33	half	half	ADV
admet-292	80	34	-	-	PUNCT
admet-292	80	35	ionized	ionize	VERB
admet-292	80	36	aggregates	aggregate	NOUN
admet-292	80	37	,	,	PUNCT
admet-292	80	38	[	[	X
admet-292	80	39	ah.a	ah.a	X
admet-292	80	40	–	–	PUNCT
admet-292	80	41	]	]	PUNCT
admet-292	80	42	n	n	CCONJ
admet-292	80	43	,	,	PUNCT
admet-292	80	44	(	(	PUNCT
admet-292	80	45	case	case	NOUN
admet-292	80	46	3a	3a	NUM
admet-292	80	47	in	in	ADP
admet-292	80	48	[	[	X
admet-292	80	49	27	27	NUM
admet-292	80	50	]	]	NUM
admet-292	80	51	)	)	PUNCT
admet-292	80	52	.	.	PUNCT
admet-292	81	1	on	on	ADP
admet-292	81	2	the	the	DET
admet-292	81	3	other	other	ADJ
admet-292	81	4	hand	hand	NOUN
admet-292	81	5	,	,	PUNCT
admet-292	81	6	it	it	PRON
admet-292	81	7	could	could	AUX
admet-292	81	8	be	be	AUX
admet-292	81	9	assumed	assume	VERB
admet-292	81	10	that	that	SCONJ
admet-292	81	11	the	the	DET
admet-292	81	12	reported	report	VERB
admet-292	81	13	pka	pka	PROPN
admet-292	81	14	is	be	AUX
admet-292	81	15	inaccurate	inaccurate	ADJ
admet-292	81	16	,	,	PUNCT
admet-292	81	17	and	and	CCONJ
admet-292	81	18	that	that	SCONJ
admet-292	81	19	no	no	DET
admet-292	81	20	aggregates	aggregate	NOUN
admet-292	81	21	form	form	VERB
admet-292	81	22	in	in	ADP
admet-292	81	23	the	the	DET
admet-292	81	24	ph	ph	ADJ
admet-292	81	25	4	4	NUM
admet-292	81	26	-	-	SYM
admet-292	81	27	5	5	NUM
admet-292	81	28	region	region	NOUN
admet-292	81	29	.	.	PUNCT
admet-292	82	1	then	then	ADV
admet-292	82	2	,	,	PUNCT
admet-292	82	3	the	the	DET
admet-292	82	4	ionization	ionization	NOUN
admet-292	82	5	constant	constant	NOUN
admet-292	82	6	determined	determine	VERB
admet-292	82	7	by	by	ADP
admet-292	82	8	pdisol	pdisol	ADJ
admet-292	82	9	-	-	PUNCT
admet-292	82	10	x	x	PRON
admet-292	82	11	would	would	AUX
admet-292	82	12	be	be	AUX
admet-292	82	13	3.94	3.94	NUM
admet-292	82	14	±	±	NUM
admet-292	82	15	0.09	0.09	NUM
admet-292	82	16	,	,	PUNCT
admet-292	82	17	using	use	VERB
admet-292	82	18	the	the	DET
admet-292	82	19	logs	log	NOUN
admet-292	82	20	-	-	PUNCT
admet-292	82	21	ph	ph	ADJ
admet-292	82	22	data	datum	NOUN
admet-292	82	23	,	,	PUNCT
admet-292	82	24	based	base	VERB
admet-292	82	25	on	on	ADP
admet-292	82	26	methods	method	NOUN
admet-292	82	27	popularized	popularize	VERB
admet-292	82	28	in	in	ADP
admet-292	82	29	older	old	ADJ
admet-292	82	30	literature	literature	NOUN
admet-292	82	31	[	[	X
admet-292	82	32	49	49	NUM
admet-292	82	33	,	,	PUNCT
admet-292	82	34	50	50	NUM
admet-292	82	35	]	]	PUNCT
admet-292	82	36	.	.	PUNCT
admet-292	83	1	such	such	DET
admet-292	83	2	a	a	DET
admet-292	83	3	big	big	ADJ
admet-292	83	4	difference	difference	NOUN
admet-292	83	5	(	(	PUNCT
admet-292	83	6	0.43	0.43	NUM
admet-292	83	7	log	log	NOUN
admet-292	83	8	unit	unit	NOUN
admet-292	83	9	)	)	PUNCT
admet-292	83	10	seems	seem	VERB
admet-292	83	11	unrealistic	unrealistic	ADJ
admet-292	83	12	,	,	PUNCT
admet-292	83	13	so	so	SCONJ
admet-292	83	14	the	the	DET
admet-292	83	15	case	case	NOUN
admet-292	83	16	for	for	ADP
admet-292	83	17	aggregation	aggregation	NOUN
admet-292	83	18	can	can	AUX
admet-292	83	19	not	not	PART
admet-292	83	20	be	be	AUX
admet-292	83	21	easily	easily	ADV
admet-292	83	22	dismissed	dismiss	VERB
admet-292	83	23	.	.	PUNCT
admet-292	84	1	for	for	ADP
admet-292	84	2	the	the	DET
admet-292	84	3	aggregate	aggregate	ADJ
admet-292	84	4	model	model	NOUN
admet-292	84	5	in	in	ADP
admet-292	84	6	the	the	DET
admet-292	84	7	figure	figure	NOUN
admet-292	84	8	,	,	PUNCT
admet-292	84	9	as	as	SCONJ
admet-292	84	10	the	the	DET
admet-292	84	11	ph	ph	NOUN
admet-292	84	12	is	be	AUX
admet-292	84	13	increased	increase	VERB
admet-292	84	14	from	from	ADP
admet-292	84	15	1	1	NUM
admet-292	84	16	to	to	ADP
admet-292	84	17	5	5	NUM
admet-292	84	18	,	,	PUNCT
admet-292	84	19	the	the	DET
admet-292	84	20	only	only	ADJ
admet-292	84	21	solid	solid	ADJ
admet-292	84	22	present	present	ADJ
admet-292	84	23	in	in	ADP
admet-292	84	24	the	the	DET
admet-292	84	25	suspension	suspension	NOUN
admet-292	84	26	is	be	AUX
admet-292	84	27	the	the	DET
admet-292	84	28	free	free	ADJ
admet-292	84	29	acid	acid	NOUN
admet-292	84	30	,	,	PUNCT
admet-292	84	31	ha	ha	INTJ
admet-292	84	32	.	.	PUNCT
admet-292	85	1	as	as	ADP
admet-292	85	2	ph	ph	ADJ
admet-292	85	3	increases	increase	NOUN
admet-292	85	4	to	to	ADP
admet-292	85	5	5	5	NUM
admet-292	85	6	,	,	PUNCT
admet-292	85	7	the	the	DET
admet-292	85	8	free	free	ADJ
admet-292	85	9	[	[	X
admet-292	85	10	ca	ca	NOUN
admet-292	85	11	2	2	NUM
admet-292	85	12	+	+	CCONJ
admet-292	85	13	]	]	PUNCT
admet-292	85	14	remains	remain	VERB
admet-292	85	15	constant	constant	ADJ
admet-292	85	16	at	at	ADP
admet-292	85	17	1.78	1.78	NUM
admet-292	85	18	mm	mm	NOUN
admet-292	85	19	,	,	PUNCT
admet-292	85	20	as	as	ADP
admet-292	85	21	[	[	X
admet-292	85	22	a	a	X
admet-292	85	23	–	–	PUNCT
admet-292	85	24	]	]	PUNCT
admet-292	85	25	increases	increase	NOUN
admet-292	85	26	.	.	PUNCT
admet-292	86	1	when	when	SCONJ
admet-292	86	2	ph	ph	NOUN
admet-292	86	3	5	5	NUM
admet-292	86	4	is	be	AUX
admet-292	86	5	reached	reach	VERB
admet-292	86	6	,	,	PUNCT
admet-292	86	7	the	the	DET
admet-292	86	8	salt	salt	NOUN
admet-292	86	9	solubility	solubility	NOUN
admet-292	86	10	product	product	NOUN
admet-292	86	11	is	be	AUX
admet-292	86	12	exceeded	exceed	VERB
admet-292	86	13	and	and	CCONJ
admet-292	86	14	the	the	DET
admet-292	86	15	calcium	calcium	NOUN
admet-292	86	16	salt	salt	NOUN
admet-292	86	17	of	of	ADP
admet-292	86	18	the	the	DET
admet-292	86	19	drug	drug	NOUN
admet-292	86	20	,	,	PUNCT
admet-292	86	21	caa2(s	caa2(s	NOUN
admet-292	86	22	)	)	PUNCT
admet-292	86	23	,	,	PUNCT
admet-292	86	24	begins	begin	VERB
admet-292	86	25	to	to	PART
admet-292	86	26	co	co	VERB
admet-292	86	27	-	-	VERB
admet-292	86	28	precipitate	precipitate	ADJ
admet-292	86	29	with	with	ADP
admet-292	86	30	ha(s	ha(	NOUN
admet-292	86	31	)	)	PUNCT
admet-292	86	32	until	until	ADP
admet-292	86	33	ph	ph	ADJ
admet-292	86	34	5.5	5.5	NUM
admet-292	86	35	.	.	PUNCT
admet-292	87	1	between	between	ADP
admet-292	87	2	ph	ph	PROPN
admet-292	87	3	5.0	5.0	NUM
admet-292	87	4	and	and	CCONJ
admet-292	87	5	5.5	5.5	NUM
admet-292	87	6	,	,	PUNCT
admet-292	87	7	the	the	DET
admet-292	87	8	calcium	calcium	NOUN
admet-292	87	9	concentration	concentration	NOUN
admet-292	87	10	decreases	decrease	NOUN
admet-292	87	11	by	by	ADP
admet-292	87	12	the	the	DET
admet-292	87	13	same	same	ADJ
admet-292	87	14	extent	extent	NOUN
admet-292	87	15	as	as	ADP
admet-292	87	16	that	that	PRON
admet-292	87	17	of	of	ADP
admet-292	87	18	atorvastatin	atorvastatin	NOUN
admet-292	87	19	anion	anion	NOUN
admet-292	87	20	increases	increase	NOUN
admet-292	87	21	,	,	PUNCT
admet-292	87	22	but	but	CCONJ
admet-292	87	23	the	the	DET
admet-292	87	24	product	product	NOUN
admet-292	88	1	[	[	X
admet-292	88	2	ca2+][a–]2	ca2+][a–]2	NOUN
admet-292	88	3	remains	remain	VERB
admet-292	88	4	constant	constant	ADJ
admet-292	88	5	.	.	PUNCT
admet-292	89	1	this	this	PRON
admet-292	89	2	is	be	AUX
admet-292	89	3	the	the	DET
admet-292	89	4	ph	ph	ADJ
admet-292	89	5	interval	interval	NOUN
admet-292	89	6	containing	contain	VERB
admet-292	89	7	two	two	NUM
admet-292	89	8	different	different	ADJ
admet-292	89	9	solids	solid	NOUN
admet-292	89	10	.	.	PUNCT
admet-292	90	1	above	above	ADP
admet-292	90	2	ph	ph	PROPN
admet-292	90	3	5.5	5.5	NUM
admet-292	90	4	(	(	PUNCT
admet-292	90	5	the	the	DET
admet-292	90	6	point	point	NOUN
admet-292	90	7	of	of	ADP
admet-292	90	8	maximum	maximum	ADJ
admet-292	90	9	solubility	solubility	NOUN
admet-292	90	10	)	)	PUNCT
admet-292	90	11	,	,	PUNCT
admet-292	90	12	all	all	DET
admet-292	90	13	ha(s	ha(	NOUN
admet-292	90	14	)	)	PUNCT
admet-292	90	15	dissolves	dissolve	VERB
admet-292	90	16	,	,	PUNCT
admet-292	90	17	as	as	ADP
admet-292	90	18	[	[	X
admet-292	90	19	ca	ca	NOUN
admet-292	90	20	2	2	NUM
admet-292	90	21	+	+	NUM
admet-292	90	22	]	]	PUNCT
admet-292	90	23	levels	level	NOUN
admet-292	90	24	off	off	ADP
admet-292	90	25	at	at	ADP
admet-292	90	26	0.09	0.09	NUM
admet-292	90	27	mm	mm	NOUN
admet-292	90	28	,	,	PUNCT
admet-292	90	29	and	and	CCONJ
admet-292	90	30	only	only	ADV
admet-292	90	31	the	the	DET
admet-292	90	32	calcium	calcium	NOUN
admet-292	90	33	salt	salt	NOUN
admet-292	90	34	is	be	AUX
admet-292	90	35	predicted	predict	VERB
admet-292	90	36	to	to	PART
admet-292	90	37	precipitate	precipitate	VERB
admet-292	90	38	,	,	PUNCT
admet-292	90	39	as	as	SCONJ
admet-292	90	40	the	the	DET
admet-292	90	41	above	above	ADJ
admet-292	90	42	product	product	NOUN
admet-292	90	43	of	of	ADP
admet-292	90	44	concentrations	concentration	NOUN
admet-292	90	45	remains	remain	VERB
admet-292	90	46	constant	constant	ADJ
admet-292	90	47	.	.	PUNCT
admet-292	91	1	it	it	PRON
admet-292	91	2	may	may	AUX
admet-292	91	3	be	be	AUX
admet-292	91	4	surprising	surprising	ADJ
admet-292	91	5	that	that	SCONJ
admet-292	91	6	as	as	ADP
admet-292	91	7	an	an	DET
admet-292	91	8	added	add	VERB
admet-292	91	9	calcium	calcium	NOUN
admet-292	91	10	salt	salt	NOUN
admet-292	91	11	,	,	PUNCT
admet-292	91	12	atorvastatin	atorvastatin	PROPN
admet-292	91	13	does	do	AUX
admet-292	91	14	not	not	PART
admet-292	91	15	have	have	VERB
admet-292	91	16	a	a	DET
admet-292	91	17	distinct	distinct	ADJ
admet-292	91	18	gibbs	gibbs	PROPN
admet-292	91	19	pka	pka	PROPN
admet-292	92	1	[	[	X
admet-292	92	2	42	42	NUM
admet-292	92	3	,	,	PUNCT
admet-292	92	4	43	43	NUM
admet-292	92	5	]	]	PUNCT
admet-292	92	6	,	,	PUNCT
admet-292	92	7	but	but	CCONJ
admet-292	92	8	rather	rather	ADV
admet-292	92	9	shows	show	VERB
admet-292	92	10	co	co	NOUN
admet-292	92	11	-	-	NOUN
admet-292	92	12	precipitation	precipitation	NOUN
admet-292	92	13	over	over	ADP
admet-292	92	14	a	a	DET
admet-292	92	15	0.5	0.5	NUM
admet-292	92	16	ph	ph	NOUN
admet-292	92	17	interval	interval	NOUN
admet-292	92	18	.	.	PUNCT
admet-292	93	1	had	have	AUX
admet-292	93	2	the	the	DET
admet-292	93	3	precipitate	precipitate	NOUN
admet-292	93	4	been	be	AUX
admet-292	93	5	between	between	ADP
admet-292	93	6	the	the	DET
admet-292	93	7	drug	drug	NOUN
admet-292	93	8	and	and	CCONJ
admet-292	93	9	sodium	sodium	NOUN
admet-292	93	10	ions	ion	NOUN
admet-292	93	11	,	,	PUNCT
admet-292	93	12	there	there	PRON
admet-292	93	13	would	would	AUX
admet-292	93	14	have	have	AUX
admet-292	93	15	been	be	AUX
admet-292	93	16	a	a	DET
admet-292	93	17	distinct	distinct	ADJ
admet-292	93	18	pka	pka	PROPN
admet-292	93	19	gibbs	gibbs	PROPN
admet-292	93	20	.	.	PUNCT
admet-292	94	1	the	the	DET
admet-292	94	2	system	system	NOUN
admet-292	94	3	is	be	AUX
admet-292	94	4	complex	complex	ADJ
admet-292	94	5	and	and	CCONJ
admet-292	94	6	several	several	ADJ
admet-292	94	7	models	model	NOUN
admet-292	94	8	can	can	AUX
admet-292	94	9	be	be	AUX
admet-292	94	10	proposed	propose	VERB
admet-292	94	11	to	to	PART
admet-292	94	12	rationalize	rationalize	VERB
admet-292	94	13	the	the	DET
admet-292	94	14	logs	log	NOUN
admet-292	94	15	-	-	PUNCT
admet-292	94	16	ph	ph	ADJ
admet-292	94	17	profile	profile	NOUN
admet-292	94	18	.	.	PUNCT
admet-292	95	1	as	as	SCONJ
admet-292	95	2	can	can	AUX
admet-292	95	3	be	be	AUX
admet-292	95	4	seen	see	VERB
admet-292	95	5	,	,	PUNCT
admet-292	95	6	the	the	DET
admet-292	95	7	independently	independently	ADV
admet-292	95	8	-	-	PUNCT
admet-292	95	9	determined	determine	VERB
admet-292	95	10	pka	pka	PROPN
admet-292	95	11	is	be	AUX
admet-292	95	12	critical	critical	ADJ
admet-292	95	13	to	to	ADP
admet-292	95	14	the	the	DET
admet-292	95	15	analysis	analysis	NOUN
admet-292	95	16	of	of	ADP
admet-292	95	17	the	the	DET
admet-292	95	18	data	datum	NOUN
admet-292	95	19	.	.	PUNCT
admet-292	96	1	it	it	PRON
admet-292	96	2	would	would	AUX
admet-292	96	3	have	have	AUX
admet-292	96	4	been	be	AUX
admet-292	96	5	important	important	ADJ
admet-292	96	6	to	to	PART
admet-292	96	7	isolate	isolate	VERB
admet-292	96	8	and	and	CCONJ
admet-292	96	9	characterize	characterize	VERB
admet-292	96	10	the	the	DET
admet-292	96	11	solids	solid	NOUN
admet-292	96	12	,	,	PUNCT
admet-292	96	13	at	at	ADP
admet-292	96	14	least	least	ADJ
admet-292	96	15	by	by	ADP
admet-292	96	16	elemental	elemental	ADJ
admet-292	96	17	analysis	analysis	NOUN
admet-292	96	18	,	,	PUNCT
admet-292	96	19	if	if	SCONJ
admet-292	96	20	not	not	PART
admet-292	96	21	by	by	ADP
admet-292	96	22	comparison	comparison	NOUN
admet-292	96	23	to	to	ADP
admet-292	96	24	pxrd	pxrd	NOUN
admet-292	96	25	of	of	ADP
admet-292	96	26	demonstrated	demonstrate	VERB
admet-292	96	27	crystalline	crystalline	ADJ
admet-292	96	28	solids	solid	NOUN
admet-292	96	29	of	of	ADP
admet-292	96	30	known	know	VERB
admet-292	96	31	stoichiometry	stoichiometry	NOUN
admet-292	96	32	.	.	PUNCT
admet-292	97	1	sufficiently	sufficiently	ADV
admet-292	97	2	sensitive	sensitive	ADJ
admet-292	97	3	computations	computation	NOUN
admet-292	97	4	tools	tool	NOUN
admet-292	97	5	are	be	AUX
admet-292	97	6	needed	need	VERB
admet-292	97	7	to	to	PART
admet-292	97	8	fully	fully	ADV
admet-292	97	9	interpret	interpret	VERB
admet-292	97	10	such	such	ADJ
admet-292	97	11	complicated	complicated	ADJ
admet-292	97	12	systems	system	NOUN
admet-292	97	13	.	.	PUNCT
admet-292	98	1	amifloxacin	amifloxacin	AUX
admet-292	98	2	figure	figure	NOUN
admet-292	98	3	1c	1c	NOUN
admet-292	98	4	shows	show	VERB
admet-292	98	5	the	the	DET
admet-292	98	6	logs	log	NOUN
admet-292	98	7	-	-	PUNCT
admet-292	98	8	ph	ph	NOUN
admet-292	98	9	profile	profile	NOUN
admet-292	98	10	of	of	ADP
admet-292	98	11	amifloxacin	amifloxacin	PROPN
admet-292	98	12	,	,	PUNCT
admet-292	98	13	an	an	DET
admet-292	98	14	ampholyte	ampholyte	NOUN
admet-292	98	15	which	which	PRON
admet-292	98	16	forms	form	VERB
admet-292	98	17	a	a	DET
admet-292	98	18	hydrochloride	hydrochloride	NOUN
admet-292	98	19	salt	salt	NOUN
admet-292	98	20	below	below	ADP
admet-292	98	21	ph	ph	PROPN
admet-292	98	22	5	5	NUM
admet-292	98	23	[	[	X
admet-292	98	24	51	51	NUM
admet-292	98	25	]	]	PUNCT
admet-292	98	26	.	.	PUNCT
admet-292	99	1	the	the	DET
admet-292	99	2	region	region	NOUN
admet-292	99	3	of	of	ADP
admet-292	99	4	maximum	maximum	PROPN
admet-292	99	5	solubility	solubility	NOUN
admet-292	99	6	near	near	ADP
admet-292	99	7	ph	ph	PROPN
admet-292	99	8	5	5	NUM
admet-292	99	9	showed	show	VERB
admet-292	99	10	supersaturation	supersaturation	NOUN
admet-292	99	11	effects	effect	NOUN
admet-292	99	12	,	,	PUNCT
admet-292	99	13	especially	especially	ADV
admet-292	99	14	at	at	ADP
admet-292	99	15	equilibration	equilibration	NOUN
admet-292	99	16	times	time	NOUN
admet-292	99	17	<	<	X
admet-292	99	18	24	24	NUM
admet-292	99	19	h.	h.	NOUN
admet-292	99	20	the	the	DET
admet-292	99	21	data	datum	NOUN
admet-292	99	22	in	in	ADP
admet-292	99	23	the	the	DET
admet-292	99	24	figure	figure	NOUN
admet-292	99	25	are	be	AUX
admet-292	99	26	based	base	VERB
admet-292	99	27	on	on	ADP
admet-292	99	28	48	48	NUM
admet-292	99	29	h	h	NOUN
admet-292	99	30	equilibration	equilibration	NOUN
admet-292	99	31	time	time	NOUN
admet-292	99	32	.	.	PUNCT
admet-292	100	1	the	the	DET
admet-292	100	2	unfilled	unfilled	ADJ
admet-292	100	3	circle	circle	NOUN
admet-292	100	4	was	be	AUX
admet-292	100	5	assigned	assign	VERB
admet-292	100	6	zero	zero	NUM
admet-292	100	7	weight	weight	NOUN
admet-292	100	8	in	in	ADP
admet-292	100	9	the	the	DET
admet-292	100	10	refinement	refinement	NOUN
admet-292	100	11	,	,	PUNCT
admet-292	100	12	since	since	SCONJ
admet-292	100	13	no	no	DET
admet-292	100	14	equilibrium	equilibrium	NOUN
admet-292	100	15	model	model	NOUN
admet-292	100	16	could	could	AUX
admet-292	100	17	be	be	AUX
admet-292	100	18	found	find	VERB
admet-292	100	19	to	to	PART
admet-292	100	20	fold	fold	VERB
admet-292	100	21	the	the	DET
admet-292	100	22	point	point	NOUN
admet-292	100	23	into	into	ADP
admet-292	100	24	the	the	DET
admet-292	100	25	curve	curve	NOUN
admet-292	100	26	represented	represent	VERB
admet-292	100	27	by	by	ADP
admet-292	100	28	the	the	DET
admet-292	100	29	other	other	ADJ
admet-292	100	30	points	point	NOUN
admet-292	100	31	.	.	PUNCT
admet-292	101	1	also	also	ADV
admet-292	101	2	,	,	PUNCT
admet-292	101	3	the	the	DET
admet-292	101	4	region	region	NOUN
admet-292	101	5	between	between	ADP
admet-292	101	6	ph	ph	PROPN
admet-292	101	7	5	5	NUM
admet-292	101	8	and	and	CCONJ
admet-292	101	9	6	6	NUM
admet-292	101	10	indicated	indicate	VERB
admet-292	101	11	the	the	DET
admet-292	101	12	presence	presence	NOUN
admet-292	101	13	of	of	ADP
admet-292	101	14	a	a	DET
admet-292	101	15	small	small	ADJ
admet-292	101	16	alex	alex	PROPN
admet-292	101	17	avdeef	avdeef	PROPN
admet-292	101	18	et	et	PROPN
admet-292	101	19	al	al	PROPN
admet-292	101	20	.	.	PROPN
admet-292	101	21	admet	admet	PROPN
admet-292	101	22	&	&	CCONJ
admet-292	101	23	dmpk	dmpk	PROPN
admet-292	101	24	4(2	4(2	NUM
admet-292	101	25	)	)	PUNCT
admet-292	101	26	(	(	PUNCT
admet-292	101	27	2016	2016	NUM
admet-292	101	28	)	)	PUNCT
admet-292	101	29	117	117	NUM
admet-292	101	30	-	-	SYM
admet-292	101	31	178	178	NUM
admet-292	101	32	122	122	NUM
admet-292	101	33	amount	amount	NOUN
admet-292	101	34	of	of	ADP
admet-292	101	35	case	case	NOUN
admet-292	101	36	2b	2b	NOUN
admet-292	101	37	-	-	NOUN
admet-292	101	38	type	type	NOUN
admet-292	101	39	in	in	ADP
admet-292	101	40	[	[	X
admet-292	101	41	27	27	NUM
admet-292	101	42	]	]	PUNCT
admet-292	101	43	cationic	cationic	ADJ
admet-292	101	44	dimeric	dimeric	ADJ
admet-292	101	45	aggregate	aggregate	NOUN
admet-292	101	46	.	.	PUNCT
admet-292	102	1	this	this	DET
admet-292	102	2	example	example	NOUN
admet-292	102	3	illustrates	illustrate	VERB
admet-292	102	4	the	the	DET
admet-292	102	5	time	time	NOUN
admet-292	102	6	dependence	dependence	NOUN
admet-292	102	7	of	of	ADP
admet-292	102	8	the	the	DET
admet-292	102	9	measured	measured	ADJ
admet-292	102	10	solubility	solubility	NOUN
admet-292	102	11	.	.	PUNCT
admet-292	103	1	ampicillin	ampicillin	PROPN
admet-292	103	2	and	and	CCONJ
admet-292	103	3	ampicillin	ampicillin	PROPN
admet-292	103	4	trihydrate	trihydrate	PROPN
admet-292	103	5	figure	figure	NOUN
admet-292	103	6	1d	1d	NUM
admet-292	103	7	shows	show	VERB
admet-292	103	8	the	the	DET
admet-292	103	9	logs	log	NOUN
admet-292	103	10	-	-	PUNCT
admet-292	103	11	ph	ph	ADJ
admet-292	103	12	profiles	profile	NOUN
admet-292	103	13	of	of	ADP
admet-292	103	14	two	two	NUM
admet-292	103	15	forms	form	NOUN
admet-292	103	16	of	of	ADP
admet-292	103	17	ampicillin	ampicillin	NOUN
admet-292	103	18	:	:	PUNCT
admet-292	103	19	anhydrous	anhydrous	ADJ
admet-292	103	20	(	(	PUNCT
admet-292	103	21	unfilled	unfilled	ADJ
admet-292	103	22	circles	circle	NOUN
admet-292	103	23	)	)	PUNCT
admet-292	103	24	and	and	CCONJ
admet-292	103	25	trihydrate	trihydrate	NOUN
admet-292	103	26	(	(	PUNCT
admet-292	103	27	filled	fill	VERB
admet-292	103	28	circles	circle	NOUN
admet-292	103	29	)	)	PUNCT
admet-292	104	1	[	[	X
admet-292	104	2	52	52	NUM
admet-292	104	3	]	]	PUNCT
admet-292	104	4	.	.	PUNCT
admet-292	105	1	it	it	PRON
admet-292	105	2	is	be	AUX
admet-292	105	3	noteworthy	noteworthy	ADJ
admet-292	105	4	that	that	SCONJ
admet-292	105	5	the	the	DET
admet-292	105	6	equilibration	equilibration	NOUN
admet-292	105	7	times	time	NOUN
admet-292	105	8	were	be	AUX
admet-292	105	9	2	2	NUM
admet-292	105	10	h	h	NOUN
admet-292	105	11	in	in	ADP
admet-292	105	12	both	both	DET
admet-292	105	13	cases	case	NOUN
admet-292	105	14	.	.	PUNCT
admet-292	106	1	had	have	AUX
admet-292	106	2	longer	long	ADV
admet-292	106	3	dissolution	dissolution	PROPN
admet-292	106	4	times	time	NOUN
admet-292	106	5	been	be	AUX
admet-292	106	6	used	use	VERB
admet-292	106	7	,	,	PUNCT
admet-292	106	8	the	the	DET
admet-292	106	9	more	more	ADV
admet-292	106	10	soluble	soluble	ADJ
admet-292	106	11	anhydrous	anhydrous	ADJ
admet-292	106	12	form	form	NOUN
admet-292	106	13	would	would	AUX
admet-292	106	14	likely	likely	ADV
admet-292	106	15	have	have	AUX
admet-292	106	16	converted	convert	VERB
admet-292	106	17	into	into	ADP
admet-292	106	18	the	the	DET
admet-292	106	19	trihydrate	trihydrate	NOUN
admet-292	106	20	.	.	PUNCT
admet-292	107	1	many	many	ADJ
admet-292	107	2	anhydrous	anhydrous	ADJ
admet-292	107	3	forms	form	NOUN
admet-292	107	4	of	of	ADP
admet-292	107	5	drugs	drug	NOUN
admet-292	107	6	are	be	AUX
admet-292	107	7	near	near	ADP
admet-292	107	8	2	2	NUM
admet-292	107	9	-	-	ADJ
admet-292	107	10	fold	fold	VERB
admet-292	107	11	higher	high	ADJ
admet-292	107	12	in	in	ADP
admet-292	107	13	solubility	solubility	NOUN
admet-292	107	14	than	than	ADP
admet-292	107	15	their	their	PRON
admet-292	107	16	hydrate	hydrate	ADJ
admet-292	107	17	counter	counter	NOUN
admet-292	107	18	parts	part	NOUN
admet-292	107	19	[	[	X
admet-292	107	20	4	4	NUM
admet-292	107	21	,	,	PUNCT
admet-292	107	22	18	18	NUM
admet-292	107	23	]	]	PUNCT
admet-292	107	24	.	.	PUNCT
admet-292	108	1	the	the	DET
admet-292	108	2	two	two	NUM
admet-292	108	3	profiles	profile	NOUN
admet-292	108	4	are	be	AUX
admet-292	108	5	well	well	ADV
admet-292	108	6	-	-	PUNCT
admet-292	108	7	described	describe	VERB
admet-292	108	8	by	by	ADP
admet-292	108	9	the	the	DET
admet-292	108	10	simple	simple	ADJ
admet-292	108	11	hh	hh	ADJ
admet-292	108	12	equation	equation	NOUN
admet-292	108	13	.	.	PUNCT
admet-292	109	1	cefadroxil	cefadroxil	NOUN
admet-292	109	2	figure	figure	PROPN
admet-292	109	3	2a	2a	PROPN
admet-292	109	4	shows	show	VERB
admet-292	109	5	the	the	DET
admet-292	109	6	logs	log	NOUN
admet-292	109	7	-	-	PUNCT
admet-292	109	8	ph	ph	NOUN
admet-292	109	9	profile	profile	NOUN
admet-292	109	10	of	of	ADP
admet-292	109	11	cefadroxil	cefadroxil	NOUN
admet-292	109	12	,	,	PUNCT
admet-292	109	13	which	which	PRON
admet-292	109	14	illustrates	illustrate	VERB
admet-292	109	15	two	two	NUM
admet-292	109	16	complicating	complicate	VERB
admet-292	109	17	aspect	aspect	NOUN
admet-292	109	18	of	of	ADP
admet-292	109	19	solubility	solubility	NOUN
admet-292	109	20	equilibria	equilibrium	NOUN
admet-292	109	21	[	[	X
admet-292	109	22	53	53	NUM
admet-292	109	23	]	]	PUNCT
admet-292	109	24	.	.	PUNCT
admet-292	110	1	the	the	DET
admet-292	110	2	study	study	NOUN
admet-292	110	3	considered	consider	VERB
admet-292	110	4	many	many	ADJ
admet-292	110	5	different	different	ADJ
admet-292	110	6	buffers	buffer	NOUN
admet-292	110	7	:	:	PUNCT
admet-292	110	8	acetate	acetate	NOUN
admet-292	110	9	,	,	PUNCT
admet-292	110	10	ammonium	ammonium	NOUN
admet-292	110	11	,	,	PUNCT
admet-292	110	12	borate	borate	NOUN
admet-292	110	13	,	,	PUNCT
admet-292	110	14	citrate	citrate	NOUN
admet-292	110	15	,	,	PUNCT
admet-292	110	16	formate	formate	NOUN
admet-292	110	17	,	,	PUNCT
admet-292	110	18	lactate	lactate	NOUN
admet-292	110	19	,	,	PUNCT
admet-292	110	20	and	and	CCONJ
admet-292	110	21	phosphate	phosphate	VERB
admet-292	110	22	.	.	PUNCT
admet-292	111	1	the	the	DET
admet-292	111	2	analysis	analysis	NOUN
admet-292	111	3	of	of	ADP
admet-292	111	4	the	the	DET
admet-292	111	5	data	datum	NOUN
admet-292	111	6	here	here	ADV
admet-292	111	7	excluded	exclude	VERB
admet-292	111	8	the	the	DET
admet-292	111	9	measurements	measurement	NOUN
admet-292	111	10	in	in	ADP
admet-292	111	11	citrate	citrate	NOUN
admet-292	111	12	(	(	PUNCT
admet-292	111	13	unfilled	unfilled	ADJ
admet-292	111	14	squares	square	NOUN
admet-292	111	15	)	)	PUNCT
admet-292	111	16	figure	figure	NOUN
admet-292	111	17	2	2	NUM
admet-292	111	18	.	.	PUNCT
admet-292	111	19	shown	show	VERB
admet-292	111	20	are	be	AUX
admet-292	111	21	three	three	NUM
admet-292	111	22	examples	example	NOUN
admet-292	111	23	of	of	ADP
admet-292	111	24	molecules	molecule	NOUN
admet-292	111	25	with	with	ADP
admet-292	111	26	logs	log	NOUN
admet-292	111	27	-	-	PUNCT
admet-292	111	28	ph	ph	ADJ
admet-292	111	29	profiles	profile	NOUN
admet-292	111	30	which	which	PRON
admet-292	111	31	are	be	AUX
admet-292	111	32	consistent	consistent	ADJ
admet-292	111	33	with	with	ADP
admet-292	111	34	the	the	DET
admet-292	111	35	presence	presence	NOUN
admet-292	111	36	of	of	ADP
admet-292	111	37	anionic	anionic	ADJ
admet-292	111	38	or	or	CCONJ
admet-292	111	39	uncharged	uncharged	ADJ
admet-292	111	40	self	self	NOUN
admet-292	111	41	-	-	PUNCT
admet-292	111	42	associated	associate	VERB
admet-292	111	43	aggregates	aggregate	NOUN
admet-292	111	44	,	,	PUNCT
admet-292	111	45	and	and	CCONJ
admet-292	111	46	one	one	NUM
admet-292	111	47	case	case	NOUN
admet-292	111	48	consistent	consistent	ADJ
admet-292	111	49	with	with	ADP
admet-292	111	50	drug	drug	NOUN
admet-292	111	51	-	-	PUNCT
admet-292	111	52	buffer	buffer	NOUN
admet-292	111	53	interaction	interaction	NOUN
admet-292	111	54	.	.	PUNCT
admet-292	112	1	and	and	CCONJ
admet-292	112	2	lactate	lactate	PROPN
admet-292	112	3	(	(	PUNCT
admet-292	112	4	unfilled	unfilled	ADJ
admet-292	112	5	circles	circle	NOUN
admet-292	112	6	)	)	PUNCT
admet-292	112	7	buffers	buffer	NOUN
admet-292	112	8	,	,	PUNCT
admet-292	112	9	since	since	SCONJ
admet-292	112	10	their	their	PRON
admet-292	112	11	solubility	solubility	NOUN
admet-292	112	12	in	in	ADP
admet-292	112	13	acidic	acidic	ADJ
admet-292	112	14	solutions	solution	NOUN
admet-292	112	15	tended	tend	VERB
admet-292	112	16	to	to	PART
admet-292	112	17	deviate	deviate	VERB
admet-292	112	18	from	from	ADP
admet-292	112	19	the	the	DET
admet-292	112	20	curve	curve	NOUN
admet-292	112	21	composed	compose	VERB
admet-292	112	22	of	of	ADP
admet-292	112	23	all	all	DET
admet-292	112	24	the	the	DET
admet-292	112	25	other	other	ADJ
admet-292	112	26	buffer	buffer	NOUN
admet-292	112	27	measurements	measurement	NOUN
admet-292	112	28	.	.	PUNCT
admet-292	113	1	the	the	DET
admet-292	113	2	elevated	elevated	ADJ
admet-292	113	3	solubility	solubility	NOUN
admet-292	113	4	of	of	ADP
admet-292	113	5	the	the	DET
admet-292	113	6	lactate	lactate	NOUN
admet-292	113	7	and	and	CCONJ
admet-292	113	8	citrate	citrate	NOUN
admet-292	113	9	cases	case	NOUN
admet-292	113	10	suggested	suggest	VERB
admet-292	113	11	that	that	SCONJ
admet-292	113	12	complexes	complex	NOUN
admet-292	113	13	might	might	AUX
admet-292	113	14	have	have	AUX
admet-292	113	15	formed	form	VERB
admet-292	113	16	between	between	ADP
admet-292	113	17	the	the	DET
admet-292	113	18	buffer	buffer	NOUN
admet-292	113	19	anions	anion	NOUN
admet-292	113	20	and	and	CCONJ
admet-292	113	21	the	the	DET
admet-292	113	22	positively	positively	ADV
admet-292	113	23	-	-	PUNCT
admet-292	113	24	charged	charge	VERB
admet-292	113	25	cefadroxil	cefadroxil	NOUN
admet-292	113	26	,	,	PUNCT
admet-292	113	27	complicating	complicate	VERB
admet-292	113	28	the	the	DET
admet-292	113	29	solution	solution	NOUN
admet-292	113	30	chemistry	chemistry	NOUN
admet-292	113	31	.	.	PUNCT
admet-292	114	1	the	the	DET
admet-292	114	2	analysis	analysis	NOUN
admet-292	114	3	of	of	ADP
admet-292	114	4	the	the	DET
admet-292	114	5	non	non	ADJ
admet-292	114	6	-	-	ADJ
admet-292	114	7	complicating	complicating	ADJ
admet-292	114	8	buffer	buffer	NOUN
admet-292	114	9	data	datum	NOUN
admet-292	114	10	yielded	yield	VERB
admet-292	114	11	the	the	DET
admet-292	114	12	solid	solid	ADJ
admet-292	114	13	curve	curve	NOUN
admet-292	114	14	in	in	ADP
admet-292	114	15	the	the	DET
admet-292	114	16	figure	figure	NOUN
admet-292	114	17	.	.	PUNCT
admet-292	115	1	evidently	evidently	ADV
admet-292	115	2	,	,	PUNCT
admet-292	115	3	the	the	DET
admet-292	115	4	data	datum	NOUN
admet-292	115	5	above	above	ADP
admet-292	115	6	ph	ph	PROPN
admet-292	115	7	6	6	NUM
admet-292	115	8	can	can	AUX
admet-292	115	9	not	not	PART
admet-292	115	10	be	be	AUX
admet-292	115	11	predicted	predict	VERB
admet-292	115	12	by	by	ADP
admet-292	115	13	the	the	DET
admet-292	115	14	simple	simple	ADJ
admet-292	115	15	hh	hh	ADJ
admet-292	115	16	equation	equation	NOUN
admet-292	115	17	.	.	PUNCT
admet-292	116	1	using	use	VERB
admet-292	116	2	pdisol	pdisol	ADJ
admet-292	116	3	-	-	PUNCT
admet-292	116	4	x	x	NOUN
admet-292	116	5	,	,	PUNCT
admet-292	116	6	the	the	DET
admet-292	116	7	admet	admet	PROPN
admet-292	116	8	&	&	CCONJ
admet-292	116	9	dmpk	dmpk	PROPN
admet-292	116	10	4(2	4(2	NUM
admet-292	116	11	)	)	PUNCT
admet-292	116	12	(	(	PUNCT
admet-292	116	13	2016	2016	NUM
admet-292	116	14	)	)	PUNCT
admet-292	116	15	117	117	NUM
admet-292	116	16	-	-	SYM
admet-292	116	17	178	178	NUM
admet-292	116	18	consensus	consensus	NOUN
admet-292	116	19	recommendations	recommendation	NOUN
admet-292	116	20	for	for	ADP
admet-292	116	21	improving	improve	VERB
admet-292	116	22	solubility	solubility	NOUN
admet-292	116	23	-	-	PUNCT
admet-292	116	24	ph	ph	ADJ
admet-292	116	25	data	datum	NOUN
admet-292	116	26	quality	quality	NOUN
admet-292	116	27	doi	doi	NOUN
admet-292	116	28	:	:	PUNCT
admet-292	116	29	10.5599	10.5599	NUM
admet-292	116	30	/	/	SYM
admet-292	116	31	admet.4.2.292	admet.4.2.292	NUM
admet-292	116	32	123	123	NUM
admet-292	116	33	data	datum	NOUN
admet-292	116	34	were	be	AUX
admet-292	116	35	best	well	ADV
admet-292	116	36	fit	fit	ADJ
admet-292	116	37	by	by	ADP
admet-292	116	38	assuming	assume	VERB
admet-292	116	39	the	the	DET
admet-292	116	40	presence	presence	NOUN
admet-292	116	41	of	of	ADP
admet-292	116	42	anionic	anionic	ADJ
admet-292	116	43	monomers	monomer	NOUN
admet-292	116	44	and	and	CCONJ
admet-292	116	45	trimers	trimer	NOUN
admet-292	116	46	(	(	PUNCT
admet-292	116	47	case	case	NOUN
admet-292	116	48	2a	2a	NUM
admet-292	116	49	in	in	ADP
admet-292	116	50	[	[	X
admet-292	116	51	27	27	NUM
admet-292	116	52	]	]	PUNCT
admet-292	116	53	)	)	PUNCT
admet-292	116	54	of	of	ADP
admet-292	116	55	cefadroxil	cefadroxil	NOUN
admet-292	116	56	.	.	PUNCT
admet-292	117	1	shoghi	shoghi	X
admet-292	117	2	et	et	PROPN
admet-292	117	3	al	al	PROPN
admet-292	117	4	.	.	PUNCT
admet-292	118	1	[	[	X
admet-292	118	2	53	53	NUM
admet-292	118	3	]	]	PUNCT
admet-292	118	4	proceeded	proceed	VERB
admet-292	118	5	to	to	PART
admet-292	118	6	analyze	analyze	VERB
admet-292	118	7	the	the	DET
admet-292	118	8	solutions	solution	NOUN
admet-292	118	9	between	between	ADP
admet-292	118	10	ph	ph	PROPN
admet-292	118	11	6	6	NUM
admet-292	118	12	and	and	CCONJ
admet-292	118	13	7	7	NUM
admet-292	118	14	using	use	VERB
admet-292	118	15	low	low	ADJ
admet-292	118	16	ionization	ionization	NOUN
admet-292	118	17	energy	energy	NOUN
admet-292	118	18	esi	esi	PROPN
admet-292	118	19	-	-	PUNCT
admet-292	118	20	qtof	qtof	ADP
admet-292	118	21	-	-	PUNCT
admet-292	118	22	ms	ms	NOUN
admet-292	118	23	/	/	SYM
admet-292	118	24	ms	ms	NOUN
admet-292	118	25	and	and	CCONJ
admet-292	118	26	found	find	VERB
admet-292	118	27	direct	direct	ADJ
admet-292	118	28	evidence	evidence	NOUN
admet-292	118	29	for	for	ADP
admet-292	118	30	the	the	DET
admet-292	118	31	presence	presence	NOUN
admet-292	118	32	of	of	ADP
admet-292	118	33	monomers	monomer	NOUN
admet-292	118	34	,	,	PUNCT
admet-292	118	35	dimers	dimer	NOUN
admet-292	118	36	and	and	CCONJ
admet-292	118	37	trimers	trimer	NOUN
admet-292	118	38	in	in	ADP
admet-292	118	39	saturated	saturate	VERB
admet-292	118	40	solution	solution	NOUN
admet-292	118	41	.	.	PUNCT
admet-292	119	1	this	this	DET
admet-292	119	2	example	example	NOUN
admet-292	119	3	illustrates	illustrate	VERB
admet-292	119	4	the	the	DET
admet-292	119	5	importance	importance	NOUN
admet-292	119	6	of	of	ADP
admet-292	119	7	corroborating	corroborate	VERB
admet-292	119	8	proposed	propose	VERB
admet-292	119	9	solution	solution	NOUN
admet-292	119	10	-	-	PUNCT
admet-292	119	11	phase	phase	NOUN
admet-292	119	12	equilibrium	equilibrium	NOUN
admet-292	119	13	models	model	NOUN
admet-292	119	14	by	by	ADP
admet-292	119	15	independent	independent	ADJ
admet-292	119	16	methods	method	NOUN
admet-292	119	17	.	.	PUNCT
admet-292	120	1	diprenorphine	diprenorphine	NOUN
admet-292	120	2	figure	figure	NOUN
admet-292	120	3	2b	2b	NUM
admet-292	120	4	shows	show	VERB
admet-292	120	5	the	the	DET
admet-292	120	6	solubility	solubility	NOUN
admet-292	120	7	profile	profile	NOUN
admet-292	120	8	of	of	ADP
admet-292	120	9	diprenorphine	diprenorphine	NOUN
admet-292	120	10	hydrochloride	hydrochloride	NOUN
admet-292	120	11	,	,	PUNCT
admet-292	120	12	xh2.cl	xh2.cl	PROPN
admet-292	120	13	,	,	PUNCT
admet-292	120	14	in	in	ADP
admet-292	120	15	the	the	DET
admet-292	120	16	modified	modify	VERB
admet-292	120	17	sørensen	sørensen	NOUN
admet-292	120	18	’s	’s	PART
admet-292	120	19	buffer	buffer	NOUN
admet-292	120	20	:	:	PUNCT
admet-292	120	21	0.15	0.15	NUM
admet-292	120	22	m	m	AUX
admet-292	120	23	nah2po4	nah2po4	ADV
admet-292	120	24	adjusted	adjust	VERB
admet-292	120	25	with	with	ADP
admet-292	120	26	14.85	14.85	NUM
admet-292	120	27	m	m	NOUN
admet-292	120	28	h3po4	h3po4	NOUN
admet-292	120	29	or	or	CCONJ
admet-292	120	30	0.5	0.5	NUM
admet-292	120	31	m	m	NOUN
admet-292	120	32	naoh	naoh	NOUN
admet-292	120	33	[	[	X
admet-292	120	34	22	22	NUM
admet-292	120	35	]	]	PUNCT
admet-292	120	36	.	.	PUNCT
admet-292	121	1	the	the	DET
admet-292	121	2	two	two	NUM
admet-292	121	3	pka	pka	PROPN
admet-292	121	4	values	value	NOUN
admet-292	121	5	of	of	ADP
admet-292	121	6	diprenorphine	diprenorphine	NOUN
admet-292	121	7	were	be	AUX
admet-292	121	8	carefully	carefully	ADV
admet-292	121	9	determined	determine	VERB
admet-292	121	10	in	in	ADP
admet-292	121	11	the	the	DET
admet-292	121	12	study	study	NOUN
admet-292	121	13	by	by	ADP
admet-292	121	14	völgyi	völgyi	PROPN
admet-292	121	15	et	et	PROPN
admet-292	121	16	al	al	PROPN
admet-292	121	17	.	.	PUNCT
admet-292	122	1	[	[	X
admet-292	122	2	22	22	NUM
admet-292	122	3	]	]	PUNCT
admet-292	122	4	.	.	PUNCT
admet-292	123	1	for	for	ADP
admet-292	123	2	ph	ph	PROPN
admet-292	123	3	>	>	X
admet-292	123	4	pka	pka	PROPN
admet-292	123	5	gibbs	gibbs	PROPN
admet-292	123	6	5.07	5.07	NUM
admet-292	123	7	,	,	PUNCT
admet-292	123	8	the	the	DET
admet-292	123	9	precipitate	precipitate	NOUN
admet-292	123	10	is	be	AUX
admet-292	123	11	the	the	DET
admet-292	123	12	uncharged	uncharged	ADJ
admet-292	123	13	ordinary	ordinary	ADJ
admet-292	123	14	ampholyte	ampholyte	NOUN
admet-292	123	15	,	,	PUNCT
admet-292	123	16	showing	show	VERB
admet-292	123	17	the	the	DET
admet-292	123	18	characteristic	characteristic	ADJ
admet-292	123	19	parabolic	parabolic	NOUN
admet-292	123	20	shape	shape	NOUN
admet-292	123	21	.	.	PUNCT
admet-292	124	1	at	at	ADP
admet-292	124	2	ph	ph	NOUN
admet-292	124	3	below	below	ADP
admet-292	124	4	the	the	DET
admet-292	124	5	gibbs	gibbs	PROPN
admet-292	124	6	pka	pka	PROPN
admet-292	124	7	,	,	PUNCT
admet-292	124	8	either	either	CCONJ
admet-292	124	9	the	the	DET
admet-292	124	10	chloride	chloride	NOUN
admet-292	124	11	or	or	CCONJ
admet-292	124	12	the	the	DET
admet-292	124	13	phosphate	phosphate	ADJ
admet-292	124	14	salt	salt	NOUN
admet-292	124	15	precipitates	precipitate	NOUN
admet-292	124	16	(	(	PUNCT
admet-292	124	17	or	or	CCONJ
admet-292	124	18	possibly	possibly	ADV
admet-292	124	19	both	both	PRON
admet-292	124	20	)	)	PUNCT
admet-292	124	21	.	.	PUNCT
admet-292	125	1	based	base	VERB
admet-292	125	2	on	on	ADP
admet-292	125	3	the	the	DET
admet-292	125	4	reported	report	VERB
admet-292	125	5	solubility	solubility	NOUN
admet-292	125	6	data	datum	NOUN
admet-292	125	7	,	,	PUNCT
admet-292	125	8	it	it	PRON
admet-292	125	9	is	be	AUX
admet-292	125	10	not	not	PART
admet-292	125	11	definitively	definitively	ADV
admet-292	125	12	certain	certain	ADJ
admet-292	125	13	which	which	DET
admet-292	125	14	form	form	NOUN
admet-292	125	15	precipitates	precipitate	NOUN
admet-292	125	16	.	.	PUNCT
admet-292	126	1	more	more	ADJ
admet-292	126	2	data	datum	NOUN
admet-292	126	3	would	would	AUX
admet-292	126	4	be	be	AUX
admet-292	126	5	needed	need	VERB
admet-292	126	6	at	at	ADP
admet-292	126	7	very	very	ADV
admet-292	126	8	low	low	ADJ
admet-292	126	9	ph	ph	ADJ
admet-292	126	10	.	.	PROPN
admet-292	126	11	alternatively	alternatively	ADV
admet-292	126	12	,	,	PUNCT
admet-292	126	13	the	the	DET
admet-292	126	14	salts	salt	NOUN
admet-292	126	15	could	could	AUX
admet-292	126	16	have	have	AUX
admet-292	126	17	been	be	AUX
admet-292	126	18	isolated	isolate	VERB
admet-292	126	19	and	and	CCONJ
admet-292	126	20	characterized	characterize	VERB
admet-292	126	21	.	.	PUNCT
admet-292	127	1	the	the	DET
admet-292	127	2	flat	flat	ADJ
admet-292	127	3	shape	shape	NOUN
admet-292	127	4	of	of	ADP
admet-292	127	5	the	the	DET
admet-292	127	6	curve	curve	NOUN
admet-292	127	7	ph	ph	VERB
admet-292	127	8	2	2	NUM
admet-292	127	9	-	-	SYM
admet-292	127	10	5	5	NUM
admet-292	127	11	is	be	AUX
admet-292	127	12	most	most	ADV
admet-292	127	13	consistent	consistent	ADJ
admet-292	127	14	with	with	ADP
admet-292	127	15	chloride	chloride	NOUN
admet-292	127	16	precipitate	precipitate	NOUN
admet-292	127	17	.	.	PUNCT
admet-292	128	1	a	a	DET
admet-292	128	2	phosphate	phosphate	ADJ
admet-292	128	3	precipitate	precipitate	NOUN
admet-292	128	4	would	would	AUX
admet-292	128	5	be	be	AUX
admet-292	128	6	expected	expect	VERB
admet-292	128	7	to	to	PART
admet-292	128	8	show	show	VERB
admet-292	128	9	an	an	DET
admet-292	128	10	upward	upward	ADJ
admet-292	128	11	curvature	curvature	NOUN
admet-292	128	12	near	near	ADP
admet-292	128	13	the	the	DET
admet-292	128	14	pka	pka	PROPN
admet-292	128	15	gibbs	gibbs	PROPN
admet-292	128	16	.	.	PUNCT
admet-292	129	1	at	at	ADP
admet-292	129	2	ph>9	ph>9	NOUN
admet-292	129	3	,	,	PUNCT
admet-292	129	4	the	the	DET
admet-292	129	5	logs	log	NOUN
admet-292	129	6	-	-	PUNCT
admet-292	129	7	ph	ph	NOUN
admet-292	129	8	curve	curve	NOUN
admet-292	129	9	shows	show	VERB
admet-292	129	10	a	a	DET
admet-292	129	11	shift	shift	NOUN
admet-292	129	12	to	to	ADP
admet-292	129	13	lower	low	ADJ
admet-292	129	14	ph	ph	VERB
admet-292	129	15	,	,	PUNCT
admet-292	129	16	compared	compare	VERB
admet-292	129	17	that	that	SCONJ
admet-292	129	18	what	what	PRON
admet-292	129	19	would	would	AUX
admet-292	129	20	be	be	AUX
admet-292	129	21	predicted	predict	VERB
admet-292	129	22	from	from	ADP
admet-292	129	23	the	the	DET
admet-292	129	24	simple	simple	ADJ
admet-292	129	25	hh	hh	ADJ
admet-292	129	26	equation	equation	NOUN
admet-292	129	27	.	.	PUNCT
admet-292	130	1	the	the	DET
admet-292	130	2	consistent	consistent	ADJ
admet-292	130	3	interpretation	interpretation	NOUN
admet-292	130	4	of	of	ADP
admet-292	130	5	the	the	DET
admet-292	130	6	shift	shift	NOUN
admet-292	130	7	is	be	AUX
admet-292	130	8	that	that	SCONJ
admet-292	130	9	a	a	DET
admet-292	130	10	water	water	NOUN
admet-292	130	11	-	-	PUNCT
admet-292	130	12	soluble	soluble	ADJ
admet-292	130	13	mixed	mix	VERB
admet-292	130	14	-	-	PUNCT
admet-292	130	15	charge	charge	NOUN
admet-292	130	16	anionic	anionic	ADJ
admet-292	130	17	dimer	dimer	NOUN
admet-292	130	18	forms	form	NOUN
admet-292	130	19	,	,	PUNCT
admet-292	130	20	with	with	ADP
admet-292	130	21	the	the	DET
admet-292	130	22	basic	basic	ADJ
admet-292	130	23	stoichiometry	stoichiometry	NOUN
admet-292	130	24	xhx	xhx	PROPN
admet-292	130	25	–	–	PUNCT
admet-292	130	26	(	(	PUNCT
admet-292	130	27	case	case	NOUN
admet-292	130	28	3a	3a	NUM
admet-292	130	29	in	in	ADP
admet-292	130	30	[	[	X
admet-292	130	31	27	27	NUM
admet-292	130	32	]	]	NUM
admet-292	130	33	)	)	PUNCT
admet-292	130	34	.	.	PUNCT
admet-292	131	1	ametryne	ametryne	PROPN
admet-292	131	2	figure	figure	NOUN
admet-292	131	3	2c	2c	NOUN
admet-292	131	4	shows	show	VERB
admet-292	131	5	the	the	DET
admet-292	131	6	solubility	solubility	NOUN
admet-292	131	7	profile	profile	NOUN
admet-292	131	8	of	of	ADP
admet-292	131	9	ametryne	ametryne	NOUN
admet-292	131	10	[	[	X
admet-292	131	11	54	54	NUM
admet-292	131	12	]	]	PUNCT
admet-292	131	13	,	,	PUNCT
admet-292	131	14	a	a	DET
admet-292	131	15	weak	weak	ADJ
admet-292	131	16	base	base	NOUN
admet-292	131	17	that	that	PRON
admet-292	131	18	appears	appear	VERB
admet-292	131	19	to	to	PART
admet-292	131	20	show	show	VERB
admet-292	131	21	free	free	ADJ
admet-292	131	22	-	-	PUNCT
admet-292	131	23	base	base	NOUN
admet-292	131	24	aggregation	aggregation	NOUN
admet-292	131	25	(	(	PUNCT
admet-292	131	26	case	case	NOUN
admet-292	131	27	1b	1b	NUM
admet-292	131	28	in	in	ADP
admet-292	131	29	[	[	X
admet-292	131	30	27	27	NUM
admet-292	131	31	]	]	NUM
admet-292	131	32	)	)	PUNCT
admet-292	131	33	.	.	PUNCT
admet-292	132	1	as	as	SCONJ
admet-292	132	2	reported	report	VERB
admet-292	132	3	,	,	PUNCT
admet-292	132	4	there	there	PRON
admet-292	132	5	was	be	VERB
admet-292	132	6	no	no	DET
admet-292	132	7	indication	indication	NOUN
admet-292	132	8	of	of	ADP
admet-292	132	9	supersaturation	supersaturation	NOUN
admet-292	132	10	effects	effect	NOUN
admet-292	132	11	at	at	ADP
admet-292	132	12	the	the	DET
admet-292	132	13	24	24	NUM
admet-292	132	14	h	h	NOUN
admet-292	132	15	equilibration	equilibration	NOUN
admet-292	132	16	.	.	PUNCT
admet-292	133	1	the	the	DET
admet-292	133	2	pka	pka	PROPN
admet-292	133	3	was	be	AUX
admet-292	133	4	spectrophotometrically	spectrophotometrically	ADV
admet-292	133	5	determined	determine	VERB
admet-292	133	6	[	[	PUNCT
admet-292	133	7	55	55	NUM
admet-292	133	8	]	]	PUNCT
admet-292	133	9	.	.	PUNCT
admet-292	134	1	several	several	ADJ
admet-292	134	2	other	other	ADJ
admet-292	134	3	derivatives	derivative	NOUN
admet-292	134	4	(	(	PUNCT
admet-292	134	5	but	but	CCONJ
admet-292	134	6	not	not	PART
admet-292	134	7	all	all	PRON
admet-292	134	8	)	)	PUNCT
admet-292	134	9	studied	study	VERB
admet-292	134	10	by	by	ADP
admet-292	134	11	ward	ward	NOUN
admet-292	134	12	and	and	CCONJ
admet-292	134	13	weber	weber	PROPN
admet-292	134	14	[	[	X
admet-292	134	15	54	54	NUM
admet-292	134	16	]	]	PUNCT
admet-292	134	17	showed	show	VERB
admet-292	134	18	the	the	DET
admet-292	134	19	characteristic	characteristic	ADJ
admet-292	134	20	case	case	NOUN
admet-292	134	21	1b	1b	NUM
admet-292	134	22	logs	log	NOUN
admet-292	134	23	-	-	PUNCT
admet-292	134	24	ph	ph	NOUN
admet-292	134	25	pattern	pattern	NOUN
admet-292	134	26	.	.	PUNCT
admet-292	135	1	if	if	SCONJ
admet-292	135	2	the	the	DET
admet-292	135	3	free	free	ADJ
admet-292	135	4	-	-	PUNCT
admet-292	135	5	base	base	NOUN
admet-292	135	6	aggregation	aggregation	NOUN
admet-292	135	7	model	model	NOUN
admet-292	135	8	were	be	AUX
admet-292	135	9	not	not	PART
admet-292	135	10	invoked	invoke	VERB
admet-292	135	11	,	,	PUNCT
admet-292	135	12	then	then	ADV
admet-292	135	13	the	the	DET
admet-292	135	14	refined	refined	ADJ
admet-292	135	15	pka	pka	PROPN
admet-292	135	16	would	would	AUX
admet-292	135	17	be	be	AUX
admet-292	135	18	3.14	3.14	NUM
admet-292	135	19	±	±	NUM
admet-292	135	20	0.08	0.08	NUM
admet-292	135	21	,	,	PUNCT
admet-292	135	22	almost	almost	ADV
admet-292	135	23	a	a	DET
admet-292	135	24	log	log	NOUN
admet-292	135	25	unit	unit	NOUN
admet-292	135	26	lower	low	ADJ
admet-292	135	27	than	than	ADP
admet-292	135	28	the	the	DET
admet-292	135	29	measured	measure	VERB
admet-292	135	30	value	value	NOUN
admet-292	135	31	.	.	PUNCT
admet-292	136	1	this	this	DET
admet-292	136	2	example	example	NOUN
admet-292	136	3	illustrates	illustrate	VERB
admet-292	136	4	the	the	DET
admet-292	136	5	need	need	NOUN
admet-292	136	6	for	for	ADP
admet-292	136	7	independently	independently	ADV
admet-292	136	8	measuring	measure	VERB
admet-292	136	9	the	the	DET
admet-292	136	10	pka	pka	NOUN
admet-292	136	11	,	,	PUNCT
admet-292	136	12	under	under	ADP
admet-292	136	13	conditions	condition	NOUN
admet-292	136	14	free	free	ADJ
admet-292	136	15	of	of	ADP
admet-292	136	16	effects	effect	NOUN
admet-292	136	17	of	of	ADP
admet-292	136	18	aggregation	aggregation	NOUN
admet-292	136	19	and	and	CCONJ
admet-292	136	20	precipitation	precipitation	NOUN
admet-292	136	21	.	.	PUNCT
admet-292	137	1	also	also	ADV
admet-292	137	2	,	,	PUNCT
admet-292	137	3	a	a	DET
admet-292	137	4	mass	mass	ADJ
admet-292	137	5	spectrophotometric	spectrophotometric	ADJ
admet-292	137	6	analysis	analysis	NOUN
admet-292	137	7	of	of	ADP
admet-292	137	8	the	the	DET
admet-292	137	9	slurry	slurry	NOUN
admet-292	137	10	in	in	ADP
admet-292	137	11	neutral	neutral	ADJ
admet-292	137	12	solution	solution	NOUN
admet-292	137	13	would	would	AUX
admet-292	137	14	have	have	AUX
admet-292	137	15	been	be	AUX
admet-292	137	16	corroboratively	corroboratively	ADV
admet-292	137	17	valuable	valuable	ADJ
admet-292	137	18	.	.	PUNCT
admet-292	138	1	haloperidol	haloperidol	VERB
admet-292	138	2	the	the	DET
admet-292	138	3	salt	salt	NOUN
admet-292	138	4	solubility	solubility	NOUN
admet-292	138	5	of	of	ADP
admet-292	138	6	haloperidol	haloperidol	PROPN
admet-292	138	7	described	describe	VERB
admet-292	138	8	by	by	ADP
admet-292	138	9	li	li	PROPN
admet-292	138	10	et	et	PROPN
admet-292	138	11	al	al	PROPN
admet-292	138	12	.	.	PUNCT
admet-292	139	1	[	[	X
admet-292	139	2	56	56	NUM
admet-292	139	3	,	,	PUNCT
admet-292	139	4	57	57	NUM
admet-292	139	5	]	]	PUNCT
admet-292	139	6	raises	raise	VERB
admet-292	139	7	several	several	ADJ
admet-292	139	8	interesting	interesting	ADJ
admet-292	139	9	points	point	NOUN
admet-292	139	10	in	in	ADP
admet-292	139	11	assay	assay	NOUN
admet-292	139	12	design	design	NOUN
admet-292	139	13	and	and	CCONJ
admet-292	139	14	data	datum	NOUN
admet-292	139	15	interpretation	interpretation	NOUN
admet-292	139	16	.	.	PUNCT
admet-292	140	1	figure	figure	NOUN
admet-292	140	2	3	3	NUM
admet-292	140	3	illustrates	illustrate	VERB
admet-292	140	4	the	the	DET
admet-292	140	5	ph	ph	ADJ
admet-292	140	6	-	-	ADJ
admet-292	140	7	dependent	dependent	ADJ
admet-292	140	8	formation	formation	NOUN
admet-292	140	9	of	of	ADP
admet-292	140	10	three	three	NUM
admet-292	140	11	crystalline	crystalline	ADJ
admet-292	140	12	salts	salt	NOUN
admet-292	140	13	of	of	ADP
admet-292	140	14	haloperidol	haloperidol	NOUN
admet-292	140	15	:	:	PUNCT
admet-292	140	16	hydrochloride	hydrochloride	NOUN
admet-292	140	17	,	,	PUNCT
admet-292	140	18	mesylate	mesylate	NOUN
admet-292	140	19	,	,	PUNCT
admet-292	140	20	and	and	CCONJ
admet-292	140	21	phosphate	phosphate	VERB
admet-292	140	22	.	.	PUNCT
admet-292	141	1	in	in	ADP
admet-292	141	2	the	the	DET
admet-292	141	3	first	first	ADJ
admet-292	141	4	three	three	NUM
admet-292	141	5	frames	frame	NOUN
admet-292	141	6	of	of	ADP
admet-292	141	7	the	the	DET
admet-292	141	8	figure	figure	NOUN
admet-292	141	9	,	,	PUNCT
admet-292	141	10	hcl	hcl	PROPN
admet-292	141	11	or	or	CCONJ
admet-292	141	12	naoh	naoh	NOUN
admet-292	141	13	were	be	AUX
admet-292	141	14	used	use	VERB
admet-292	141	15	to	to	PART
admet-292	141	16	adjust	adjust	VERB
admet-292	141	17	the	the	DET
admet-292	141	18	ph	ph	NOUN
admet-292	141	19	of	of	ADP
admet-292	141	20	haloperidol	haloperidol	NOUN
admet-292	141	21	,	,	PUNCT
admet-292	141	22	either	either	CCONJ
admet-292	141	23	introduced	introduce	VERB
admet-292	141	24	as	as	ADP
admet-292	141	25	a	a	DET
admet-292	141	26	free	free	ADJ
admet-292	141	27	base	base	NOUN
admet-292	141	28	(	(	PUNCT
admet-292	141	29	figure	figure	NOUN
admet-292	141	30	3a	3a	NUM
admet-292	141	31	)	)	PUNCT
admet-292	141	32	or	or	CCONJ
admet-292	141	33	as	as	ADP
admet-292	141	34	a	a	DET
admet-292	141	35	hydrochloride	hydrochloride	NOUN
admet-292	141	36	(	(	PUNCT
admet-292	141	37	figure	figure	NOUN
admet-292	141	38	3b	3b	NUM
admet-292	141	39	)	)	PUNCT
admet-292	141	40	.	.	PUNCT
admet-292	142	1	within	within	ADP
admet-292	142	2	the	the	DET
admet-292	142	3	bounds	bound	NOUN
admet-292	142	4	of	of	ADP
admet-292	142	5	experimental	experimental	ADJ
admet-292	142	6	errors	error	NOUN
admet-292	142	7	,	,	PUNCT
admet-292	142	8	the	the	DET
admet-292	142	9	results	result	NOUN
admet-292	142	10	are	be	AUX
admet-292	142	11	largely	largely	ADV
admet-292	142	12	the	the	DET
admet-292	142	13	same	same	ADJ
admet-292	142	14	.	.	PUNCT
admet-292	143	1	the	the	DET
admet-292	143	2	data	datum	NOUN
admet-292	143	3	in	in	ADP
admet-292	143	4	the	the	DET
admet-292	143	5	hydrochloride	hydrochloride	NOUN
admet-292	143	6	case	case	NOUN
admet-292	143	7	(	(	PUNCT
admet-292	143	8	figure	figure	NOUN
admet-292	143	9	3b	3b	NUM
admet-292	143	10	)	)	PUNCT
admet-292	143	11	above	above	ADP
admet-292	143	12	ph	ph	X
admet-292	143	13	8	8	NUM
admet-292	143	14	indicate	indicate	VERB
admet-292	143	15	a	a	DET
admet-292	143	16	non	non	ADJ
admet-292	143	17	-	-	ADJ
admet-292	143	18	hh	hh	ADJ
admet-292	143	19	effect	effect	NOUN
admet-292	143	20	,	,	PUNCT
admet-292	143	21	which	which	PRON
admet-292	143	22	can	can	AUX
admet-292	143	23	be	be	AUX
admet-292	143	24	due	due	ADJ
admet-292	143	25	to	to	ADP
admet-292	143	26	three	three	NUM
admet-292	143	27	situations	situation	NOUN
admet-292	143	28	:	:	PUNCT
admet-292	143	29	(	(	PUNCT
admet-292	143	30	i	i	NOUN
admet-292	143	31	)	)	PUNCT
admet-292	143	32	formation	formation	NOUN
admet-292	143	33	of	of	ADP
admet-292	143	34	uncharged	uncharged	ADJ
admet-292	143	35	aggregates	aggregate	NOUN
admet-292	143	36	(	(	PUNCT
admet-292	143	37	case	case	NOUN
admet-292	143	38	1b	1b	NUM
admet-292	143	39	in	in	ADP
admet-292	143	40	[	[	X
admet-292	143	41	27	27	NUM
admet-292	143	42	]	]	NUM
admet-292	143	43	)	)	PUNCT
admet-292	143	44	,	,	PUNCT
admet-292	143	45	or	or	CCONJ
admet-292	143	46	(	(	PUNCT
admet-292	143	47	ii	ii	NOUN
admet-292	143	48	)	)	PUNCT
admet-292	143	49	24	24	NUM
admet-292	143	50	h	h	NOUN
admet-292	143	51	time	time	NOUN
admet-292	143	52	not	not	PART
admet-292	143	53	being	be	AUX
admet-292	143	54	adequate	adequate	ADJ
admet-292	143	55	to	to	PART
admet-292	143	56	reach	reach	VERB
admet-292	143	57	full	full	ADJ
admet-292	143	58	equilibration	equilibration	NOUN
admet-292	143	59	,	,	PUNCT
admet-292	143	60	or	or	CCONJ
admet-292	143	61	(	(	PUNCT
admet-292	143	62	iii	iii	X
admet-292	143	63	)	)	PUNCT
admet-292	143	64	the	the	DET
admet-292	143	65	formation	formation	NOUN
admet-292	143	66	of	of	ADP
admet-292	143	67	an	an	DET
admet-292	143	68	oil	oil	NOUN
admet-292	143	69	phase	phase	NOUN
admet-292	143	70	(	(	PUNCT
admet-292	143	71	liquid	liquid	NOUN
admet-292	143	72	-	-	PUNCT
admet-292	143	73	liquid	liquid	NOUN
admet-292	143	74	phase	phase	NOUN
admet-292	143	75	separation	separation	NOUN
admet-292	143	76	,	,	PUNCT
admet-292	143	77	llps	llp	VERB
admet-292	143	78	[	[	X
admet-292	143	79	58	58	NUM
admet-292	143	80	,	,	PUNCT
admet-292	143	81	59	59	NUM
admet-292	143	82	]	]	PUNCT
admet-292	143	83	)	)	PUNCT
admet-292	143	84	,	,	PUNCT
admet-292	143	85	which	which	PRON
admet-292	143	86	is	be	AUX
admet-292	143	87	more	more	ADV
admet-292	143	88	soluble	soluble	ADJ
admet-292	143	89	than	than	ADP
admet-292	143	90	the	the	DET
admet-292	143	91	free	free	ADJ
admet-292	143	92	-	-	PUNCT
admet-292	143	93	base	base	NOUN
admet-292	143	94	crystalline	crystalline	NOUN
admet-292	143	95	phase	phase	NOUN
admet-292	143	96	(	(	PUNCT
admet-292	143	97	melting	melting	NOUN
admet-292	143	98	point	point	NOUN
admet-292	143	99	,	,	PUNCT
admet-292	143	100	149	149	NUM
admet-292	143	101	°	°	NOUN
admet-292	143	102	c	c	NOUN
admet-292	143	103	)	)	PUNCT
admet-292	143	104	.	.	PUNCT
admet-292	144	1	ignoring	ignore	VERB
admet-292	144	2	this	this	PRON
admet-292	144	3	[	[	X
admet-292	144	4	49	49	NUM
admet-292	144	5	,	,	PUNCT
admet-292	144	6	50	50	NUM
admet-292	144	7	]	]	PUNCT
admet-292	144	8	,	,	PUNCT
admet-292	144	9	the	the	DET
admet-292	144	10	logs	log	NOUN
admet-292	144	11	-	-	PUNCT
admet-292	144	12	ph	ph	ADJ
admet-292	144	13	data	datum	NOUN
admet-292	144	14	above	above	ADP
admet-292	144	15	ph	ph	X
admet-292	144	16	7	7	NUM
admet-292	144	17	might	might	AUX
admet-292	144	18	suggest	suggest	VERB
admet-292	144	19	that	that	SCONJ
admet-292	144	20	the	the	DET
admet-292	144	21	pka	pka	PROPN
admet-292	144	22	of	of	ADP
admet-292	144	23	haloperidol	haloperidol	NOUN
admet-292	144	24	at	at	ADP
admet-292	144	25	37	37	NUM
admet-292	144	26	°	°	NOUN
admet-292	144	27	c	c	NOUN
admet-292	144	28	is	be	AUX
admet-292	144	29	8.0	8.0	NUM
admet-292	144	30	.	.	PUNCT
admet-292	145	1	this	this	PRON
admet-292	145	2	would	would	AUX
admet-292	145	3	not	not	PART
admet-292	145	4	be	be	AUX
admet-292	145	5	in	in	ADP
admet-292	145	6	agreement	agreement	NOUN
admet-292	145	7	with	with	ADP
admet-292	145	8	the	the	DET
admet-292	145	9	pka	pka	PROPN
admet-292	145	10	8.29	8.29	NUM
admet-292	145	11	independently	independently	ADV
admet-292	145	12	determined	determine	VERB
admet-292	145	13	at	at	ADP
admet-292	145	14	37	37	NUM
admet-292	145	15	°	°	NOUN
admet-292	145	16	c	c	NOUN
admet-292	145	17	[	[	X
admet-292	145	18	60	60	NUM
admet-292	145	19	]	]	PUNCT
admet-292	145	20	and	and	CCONJ
admet-292	145	21	8.60	8.60	NUM
admet-292	145	22	at	at	ADP
admet-292	145	23	alex	alex	PROPN
admet-292	145	24	avdeef	avdeef	PROPN
admet-292	145	25	et	et	PROPN
admet-292	145	26	al	al	PROPN
admet-292	145	27	.	.	PROPN
admet-292	145	28	admet	admet	PROPN
admet-292	145	29	&	&	CCONJ
admet-292	145	30	dmpk	dmpk	PROPN
admet-292	145	31	4(2	4(2	NUM
admet-292	145	32	)	)	PUNCT
admet-292	145	33	(	(	PUNCT
admet-292	145	34	2016	2016	NUM
admet-292	145	35	)	)	PUNCT
admet-292	145	36	117	117	NUM
admet-292	145	37	-	-	SYM
admet-292	145	38	178	178	NUM
admet-292	145	39	124	124	NUM
admet-292	145	40	25	25	NUM
admet-292	145	41	°	°	NUM
admet-292	145	42	c	c	NOUN
admet-292	145	43	[	[	X
admet-292	145	44	61	61	NUM
admet-292	145	45	]	]	PUNCT
admet-292	145	46	.	.	PUNCT
admet-292	146	1	based	base	VERB
admet-292	146	2	solely	solely	ADV
admet-292	146	3	on	on	ADP
admet-292	146	4	the	the	DET
admet-292	146	5	solubility	solubility	NOUN
admet-292	146	6	measurements	measurement	NOUN
admet-292	146	7	,	,	PUNCT
admet-292	146	8	none	none	NOUN
admet-292	146	9	of	of	ADP
admet-292	146	10	the	the	DET
admet-292	146	11	three	three	NUM
admet-292	146	12	possibilities	possibility	NOUN
admet-292	146	13	can	can	AUX
admet-292	146	14	be	be	AUX
admet-292	146	15	definitively	definitively	ADV
admet-292	146	16	ruled	rule	VERB
admet-292	146	17	out	out	ADP
admet-292	146	18	,	,	PUNCT
admet-292	146	19	and	and	CCONJ
admet-292	146	20	additional	additional	ADJ
admet-292	146	21	investigation	investigation	NOUN
admet-292	146	22	might	might	AUX
admet-292	146	23	be	be	AUX
admet-292	146	24	desirable	desirable	ADJ
admet-292	146	25	.	.	PUNCT
admet-292	147	1	figure	figure	NOUN
admet-292	147	2	3	3	NUM
admet-292	147	3	.	.	PUNCT
admet-292	148	1	examples	example	NOUN
admet-292	148	2	of	of	ADP
admet-292	148	3	logs	log	NOUN
admet-292	148	4	-	-	PUNCT
admet-292	148	5	ph	ph	ADJ
admet-292	148	6	profiles	profile	NOUN
admet-292	148	7	of	of	ADP
admet-292	148	8	haloperidol	haloperidol	NOUN
admet-292	148	9	resulting	result	VERB
admet-292	148	10	from	from	ADP
admet-292	148	11	different	different	ADJ
admet-292	148	12	salt	salt	NOUN
admet-292	148	13	precipitations	precipitation	NOUN
admet-292	148	14	,	,	PUNCT
admet-292	148	15	illustrating	illustrate	VERB
admet-292	148	16	some	some	DET
admet-292	148	17	degree	degree	NOUN
admet-292	148	18	of	of	ADP
admet-292	148	19	supersaturation	supersaturation	NOUN
admet-292	148	20	near	near	ADP
admet-292	148	21	the	the	DET
admet-292	148	22	gibbs	gibbs	PROPN
admet-292	148	23	pka	pka	PROPN
admet-292	148	24	in	in	ADP
admet-292	148	25	the	the	DET
admet-292	148	26	ph	ph	ADJ
admet-292	148	27	4.1	4.1	NUM
admet-292	148	28	-	-	SYM
admet-292	148	29	4.9	4.9	NUM
admet-292	148	30	interval	interval	NOUN
admet-292	148	31	and	and	CCONJ
admet-292	148	32	the	the	DET
admet-292	148	33	possible	possible	ADJ
admet-292	148	34	formation	formation	NOUN
admet-292	148	35	of	of	ADP
admet-292	148	36	uncharged	uncharged	ADJ
admet-292	148	37	aggregates	aggregate	NOUN
admet-292	148	38	for	for	ADP
admet-292	148	39	ph>8	ph>8	PROPN
admet-292	148	40	(	(	PUNCT
admet-292	148	41	see	see	VERB
admet-292	148	42	text	text	NOUN
admet-292	148	43	)	)	PUNCT
admet-292	148	44	.	.	PUNCT
admet-292	149	1	figure	figure	VERB
admet-292	149	2	3c	3c	NUM
admet-292	149	3	depicts	depict	VERB
admet-292	149	4	the	the	DET
admet-292	149	5	titration	titration	NOUN
admet-292	149	6	of	of	ADP
admet-292	149	7	the	the	DET
admet-292	149	8	haloperidol	haloperidol	ADJ
admet-292	149	9	mesylate	mesylate	NOUN
admet-292	149	10	salt	salt	NOUN
admet-292	149	11	by	by	ADP
admet-292	149	12	either	either	CCONJ
admet-292	149	13	hcl	hcl	PROPN
admet-292	149	14	or	or	CCONJ
admet-292	149	15	naoh	naoh	NOUN
admet-292	149	16	.	.	PUNCT
admet-292	150	1	the	the	DET
admet-292	150	2	higher	high	ADJ
admet-292	150	3	solubility	solubility	NOUN
admet-292	150	4	in	in	ADP
admet-292	150	5	the	the	DET
admet-292	150	6	salt	salt	NOUN
admet-292	150	7	precipitation	precipitation	NOUN
admet-292	150	8	region	region	NOUN
admet-292	150	9	(	(	PUNCT
admet-292	150	10	ph	ph	NOUN
admet-292	150	11	2	2	NUM
admet-292	150	12	-	-	SYM
admet-292	150	13	4	4	NUM
admet-292	150	14	)	)	PUNCT
admet-292	150	15	compared	compare	VERB
admet-292	150	16	to	to	ADP
admet-292	150	17	that	that	PRON
admet-292	150	18	in	in	ADP
admet-292	150	19	figures	figure	NOUN
admet-292	150	20	3a	3a	NUM
admet-292	150	21	and	and	CCONJ
admet-292	150	22	3b	3b	NOUN
admet-292	150	23	suggests	suggest	VERB
admet-292	150	24	that	that	SCONJ
admet-292	150	25	the	the	DET
admet-292	150	26	precipitate	precipitate	NOUN
admet-292	150	27	is	be	AUX
admet-292	150	28	the	the	DET
admet-292	150	29	mesylate	mesylate	NOUN
admet-292	150	30	salt	salt	NOUN
admet-292	150	31	of	of	ADP
admet-292	150	32	haloperidol	haloperidol	NOUN
admet-292	150	33	.	.	PUNCT
admet-292	151	1	however	however	ADV
admet-292	151	2	,	,	PUNCT
admet-292	151	3	the	the	DET
admet-292	151	4	five	five	NUM
admet-292	151	5	lowest	low	ADJ
admet-292	151	6	-	-	PUNCT
admet-292	151	7	ph	ph	NOUN
admet-292	151	8	points	point	NOUN
admet-292	151	9	(	(	PUNCT
admet-292	151	10	figure	figure	NOUN
admet-292	151	11	3c	3c	NUM
admet-292	151	12	)	)	PUNCT
admet-292	151	13	are	be	AUX
admet-292	151	14	not	not	PART
admet-292	151	15	indicative	indicative	ADJ
admet-292	151	16	of	of	ADP
admet-292	151	17	a	a	DET
admet-292	151	18	mesylate	mesylate	NOUN
admet-292	151	19	salt	salt	NOUN
admet-292	151	20	.	.	PUNCT
admet-292	152	1	at	at	ADP
admet-292	152	2	the	the	DET
admet-292	152	3	lowest	low	ADJ
admet-292	152	4	ph	ph	VERB
admet-292	152	5	,	,	PUNCT
admet-292	152	6	the	the	DET
admet-292	152	7	data	datum	NOUN
admet-292	152	8	were	be	AUX
admet-292	152	9	better	well	ADV
admet-292	152	10	fitted	fit	VERB
admet-292	152	11	with	with	ADP
admet-292	152	12	the	the	DET
admet-292	152	13	ksp	ksp	PROPN
admet-292	152	14	corresponding	corresponding	NOUN
admet-292	152	15	to	to	ADP
admet-292	152	16	the	the	DET
admet-292	152	17	hydrochloride	hydrochloride	NOUN
admet-292	152	18	admet	admet	NOUN
admet-292	152	19	&	&	CCONJ
admet-292	152	20	dmpk	dmpk	PROPN
admet-292	152	21	4(2	4(2	NUM
admet-292	152	22	)	)	PUNCT
admet-292	152	23	(	(	PUNCT
admet-292	152	24	2016	2016	NUM
admet-292	152	25	)	)	PUNCT
admet-292	152	26	117	117	NUM
admet-292	152	27	-	-	SYM
admet-292	152	28	178	178	NUM
admet-292	152	29	consensus	consensus	NOUN
admet-292	152	30	recommendations	recommendation	NOUN
admet-292	152	31	for	for	ADP
admet-292	152	32	improving	improve	VERB
admet-292	152	33	solubility	solubility	NOUN
admet-292	152	34	-	-	PUNCT
admet-292	152	35	ph	ph	ADJ
admet-292	152	36	data	datum	NOUN
admet-292	152	37	quality	quality	NOUN
admet-292	152	38	doi	doi	NOUN
admet-292	152	39	:	:	PUNCT
admet-292	152	40	10.5599	10.5599	NUM
admet-292	152	41	/	/	SYM
admet-292	152	42	admet.4.2.292	admet.4.2.292	NUM
admet-292	152	43	125	125	NUM
admet-292	152	44	salt	salt	NOUN
admet-292	152	45	.	.	PUNCT
admet-292	153	1	because	because	SCONJ
admet-292	153	2	of	of	ADP
admet-292	153	3	the	the	DET
admet-292	153	4	very	very	ADV
admet-292	153	5	low	low	ADJ
admet-292	153	6	ph	ph	NOUN
admet-292	153	7	(	(	PUNCT
admet-292	153	8	<	<	X
admet-292	153	9	1	1	NUM
admet-292	153	10	)	)	PUNCT
admet-292	153	11	,	,	PUNCT
admet-292	153	12	it	it	PRON
admet-292	153	13	was	be	AUX
admet-292	153	14	necessary	necessary	ADJ
admet-292	153	15	to	to	PART
admet-292	153	16	invoke	invoke	VERB
admet-292	153	17	a	a	DET
admet-292	153	18	ph	ph	ADJ
admet-292	153	19	electrode	electrode	NOUN
admet-292	153	20	junction	junction	NOUN
admet-292	153	21	potential	potential	ADJ
admet-292	153	22	effect	effect	NOUN
admet-292	153	23	(	(	PUNCT
admet-292	153	24	jh=+0.35	jh=+0.35	NOUN
admet-292	153	25	[	[	PUNCT
admet-292	153	26	45	45	NUM
admet-292	153	27	]	]	PUNCT
admet-292	153	28	;	;	PUNCT
admet-292	153	29	cf	cf	X
admet-292	153	30	.	.	NOUN
admet-292	153	31	,	,	PUNCT
admet-292	153	32	appendix	appendix	VERB
admet-292	153	33	c	c	NOUN
admet-292	153	34	)	)	PUNCT
admet-292	153	35	.	.	PUNCT
admet-292	154	1	this	this	PRON
admet-292	154	2	was	be	AUX
admet-292	154	3	also	also	ADV
admet-292	154	4	needed	need	VERB
admet-292	154	5	in	in	ADP
admet-292	154	6	the	the	DET
admet-292	154	7	cases	case	NOUN
admet-292	154	8	of	of	ADP
admet-292	154	9	figure	figure	NOUN
admet-292	154	10	3b	3b	NOUN
admet-292	154	11	and	and	CCONJ
admet-292	154	12	3d	3d	NUM
admet-292	154	13	,	,	PUNCT
admet-292	154	14	for	for	ADP
admet-292	154	15	ph	ph	ADJ
admet-292	154	16			NOUN
admet-292	154	17	1	1	NUM
admet-292	154	18	.	.	PUNCT
admet-292	155	1	in	in	ADP
admet-292	155	2	the	the	DET
admet-292	155	3	low	low	ADJ
admet-292	155	4	-	-	PUNCT
admet-292	155	5	ph	ph	ADJ
admet-292	155	6	mesylate	mesylate	NOUN
admet-292	155	7	example	example	NOUN
admet-292	155	8	,	,	PUNCT
admet-292	155	9	there	there	PRON
admet-292	155	10	is	be	VERB
admet-292	155	11	actually	actually	ADV
admet-292	155	12	a	a	DET
admet-292	155	13	region	region	NOUN
admet-292	155	14	predicted	predict	VERB
admet-292	155	15	to	to	PART
admet-292	155	16	contain	contain	VERB
admet-292	155	17	co	co	NOUN
admet-292	155	18	-	-	NOUN
admet-292	155	19	precipitates	precipitate	NOUN
admet-292	155	20	of	of	ADP
admet-292	155	21	both	both	DET
admet-292	155	22	bh.cl(s	bh.cl(	NOUN
admet-292	155	23	)	)	PUNCT
admet-292	155	24	and	and	CCONJ
admet-292	155	25	bh.mesylate(s	bh.mesylate(s	NOUN
admet-292	155	26	)	)	PUNCT
admet-292	155	27	.	.	PUNCT
admet-292	156	1	figure	figure	NOUN
admet-292	156	2	3d	3d	PROPN
admet-292	156	3	is	be	AUX
admet-292	156	4	an	an	DET
admet-292	156	5	example	example	NOUN
admet-292	156	6	of	of	ADP
admet-292	156	7	haloperidol	haloperidol	PROPN
admet-292	156	8	introduced	introduce	VERB
admet-292	156	9	as	as	ADP
admet-292	156	10	the	the	DET
admet-292	156	11	mesylate	mesylate	NOUN
admet-292	156	12	salt	salt	NOUN
admet-292	156	13	and	and	CCONJ
admet-292	156	14	titrated	titrate	VERB
admet-292	156	15	with	with	ADP
admet-292	156	16	either	either	CCONJ
admet-292	156	17	mesylic	mesylic	ADJ
admet-292	156	18	acid	acid	NOUN
admet-292	156	19	or	or	CCONJ
admet-292	156	20	naoh	naoh	NOUN
admet-292	156	21	.	.	PUNCT
admet-292	157	1	the	the	DET
admet-292	157	2	same	same	ADJ
admet-292	157	3	solubility	solubility	NOUN
admet-292	157	4	is	be	AUX
admet-292	157	5	evident	evident	ADJ
admet-292	157	6	in	in	ADP
admet-292	157	7	the	the	DET
admet-292	157	8	ph	ph	ADJ
admet-292	157	9	2	2	NUM
admet-292	157	10	-	-	SYM
admet-292	157	11	4	4	NUM
admet-292	157	12	region	region	NOUN
admet-292	157	13	as	as	ADP
admet-292	157	14	that	that	PRON
admet-292	157	15	shown	show	VERB
admet-292	157	16	in	in	ADP
admet-292	157	17	figure	figure	NOUN
admet-292	157	18	3c	3c	NUM
admet-292	157	19	.	.	PUNCT
admet-292	158	1	the	the	DET
admet-292	158	2	precipitous	precipitous	ADJ
admet-292	158	3	drop	drop	NOUN
admet-292	158	4	in	in	ADP
admet-292	158	5	solubility	solubility	NOUN
admet-292	158	6	at	at	ADP
admet-292	158	7	low	low	ADJ
admet-292	158	8	ph	ph	NOUN
admet-292	158	9	in	in	ADP
admet-292	158	10	figure	figure	NOUN
admet-292	158	11	3c	3c	NUM
admet-292	158	12	arises	arise	VERB
admet-292	158	13	as	as	ADP
admet-292	158	14	a	a	DET
admet-292	158	15	“	"	PUNCT
admet-292	158	16	common	common	ADJ
admet-292	158	17	ion	ion	NOUN
admet-292	158	18	”	"	PUNCT
admet-292	158	19	effect	effect	NOUN
admet-292	158	20	,	,	PUNCT
admet-292	158	21	namely	namely	ADV
admet-292	158	22	that	that	SCONJ
admet-292	158	23	in	in	ADP
admet-292	158	24	the	the	DET
admet-292	158	25	ph	ph	ADJ
admet-292	158	26	2	2	NUM
admet-292	158	27	-	-	SYM
admet-292	158	28	4	4	NUM
admet-292	158	29	region	region	NOUN
admet-292	158	30	,	,	PUNCT
admet-292	158	31	the	the	DET
admet-292	158	32	concentration	concentration	NOUN
admet-292	158	33	of	of	ADP
admet-292	158	34	chloride	chloride	NOUN
admet-292	158	35	contributed	contribute	VERB
admet-292	158	36	by	by	ADP
admet-292	158	37	the	the	DET
admet-292	158	38	hcl	hcl	PROPN
admet-292	158	39	titrant	titrant	NOUN
admet-292	158	40	is	be	AUX
admet-292	158	41	not	not	PART
admet-292	158	42	high	high	ADJ
admet-292	158	43	enough	enough	ADV
admet-292	158	44	to	to	PART
admet-292	158	45	exceed	exceed	VERB
admet-292	158	46	the	the	DET
admet-292	158	47	solubility	solubility	NOUN
admet-292	158	48	product	product	NOUN
admet-292	158	49	of	of	ADP
admet-292	158	50	bh.cl(s	bh.cl(s	PROPN
admet-292	158	51	)	)	PUNCT
admet-292	158	52	,	,	PUNCT
admet-292	158	53	until	until	SCONJ
admet-292	158	54	enough	enough	ADJ
admet-292	158	55	hcl	hcl	PROPN
admet-292	158	56	had	have	AUX
admet-292	158	57	been	be	AUX
admet-292	158	58	added	add	VERB
admet-292	158	59	to	to	PART
admet-292	158	60	reach	reach	VERB
admet-292	158	61	the	the	DET
admet-292	158	62	very	very	ADV
admet-292	158	63	low	low	ADJ
admet-292	158	64	ph	ph	ADJ
admet-292	158	65	values	value	NOUN
admet-292	158	66	(	(	PUNCT
admet-292	158	67	ph<2	ph<2	PROPN
admet-292	158	68	)	)	PUNCT
admet-292	158	69	.	.	PUNCT
admet-292	159	1	in	in	ADP
admet-292	159	2	figures	figure	NOUN
admet-292	159	3	3c	3c	NUM
admet-292	159	4	and	and	CCONJ
admet-292	159	5	3d	3d	NUM
admet-292	159	6	,	,	PUNCT
admet-292	159	7	the	the	DET
admet-292	159	8	unfilled	unfilled	ADJ
admet-292	159	9	circles	circle	NOUN
admet-292	159	10	were	be	AUX
admet-292	159	11	assigned	assign	VERB
admet-292	159	12	zero	zero	NUM
admet-292	159	13	weights	weight	NOUN
admet-292	159	14	in	in	ADP
admet-292	159	15	the	the	DET
admet-292	159	16	regression	regression	NOUN
admet-292	159	17	analysis	analysis	NOUN
admet-292	159	18	.	.	PUNCT
admet-292	160	1	the	the	DET
admet-292	160	2	reasonable	reasonable	ADJ
admet-292	160	3	explanation	explanation	NOUN
admet-292	160	4	for	for	ADP
admet-292	160	5	their	their	PRON
admet-292	160	6	deviancy	deviancy	NOUN
admet-292	160	7	from	from	ADP
admet-292	160	8	the	the	DET
admet-292	160	9	models	model	NOUN
admet-292	160	10	is	be	AUX
admet-292	160	11	due	due	ADJ
admet-292	160	12	to	to	ADP
admet-292	160	13	supersaturation	supersaturation	NOUN
admet-292	160	14	effects	effect	NOUN
admet-292	160	15	.	.	PUNCT
admet-292	161	1	figure	figure	NOUN
admet-292	161	2	3e	3e	PROPN
admet-292	161	3	is	be	AUX
admet-292	161	4	an	an	DET
admet-292	161	5	example	example	NOUN
admet-292	161	6	of	of	ADP
admet-292	161	7	haloperidol	haloperidol	PROPN
admet-292	161	8	introduced	introduce	VERB
admet-292	161	9	as	as	ADP
admet-292	161	10	the	the	DET
admet-292	161	11	phosphate	phosphate	ADJ
admet-292	161	12	salt	salt	NOUN
admet-292	161	13	and	and	CCONJ
admet-292	161	14	titrated	titrate	VERB
admet-292	161	15	with	with	ADP
admet-292	161	16	either	either	CCONJ
admet-292	161	17	phosphoric	phosphoric	ADJ
admet-292	161	18	acid	acid	NOUN
admet-292	161	19	or	or	CCONJ
admet-292	161	20	naoh	naoh	NOUN
admet-292	161	21	.	.	PUNCT
admet-292	162	1	no	no	DET
admet-292	162	2	way	way	NOUN
admet-292	162	3	was	be	AUX
admet-292	162	4	found	find	VERB
admet-292	162	5	to	to	PART
admet-292	162	6	rationalize	rationalize	VERB
admet-292	162	7	the	the	DET
admet-292	162	8	three	three	NUM
admet-292	162	9	points	point	NOUN
admet-292	162	10	(	(	PUNCT
admet-292	162	11	unfilled	unfilled	ADJ
admet-292	162	12	circles	circle	NOUN
admet-292	162	13	)	)	PUNCT
admet-292	162	14	with	with	ADP
admet-292	162	15	the	the	DET
admet-292	162	16	lowest	low	ADJ
admet-292	162	17	ph	ph	VERB
admet-292	162	18	,	,	PUNCT
admet-292	162	19	so	so	SCONJ
admet-292	162	20	they	they	PRON
admet-292	162	21	were	be	AUX
admet-292	162	22	assigned	assign	VERB
admet-292	162	23	zero	zero	NUM
admet-292	162	24	weights	weight	NOUN
admet-292	162	25	.	.	PUNCT
admet-292	163	1	it	it	PRON
admet-292	163	2	is	be	AUX
admet-292	163	3	interesting	interesting	ADJ
admet-292	163	4	to	to	PART
admet-292	163	5	note	note	VERB
admet-292	163	6	in	in	ADP
admet-292	163	7	the	the	DET
admet-292	163	8	haloperidol	haloperidol	NOUN
admet-292	163	9	case	case	NOUN
admet-292	163	10	study	study	NOUN
admet-292	163	11	that	that	SCONJ
admet-292	163	12	the	the	DET
admet-292	163	13	order	order	NOUN
admet-292	163	14	of	of	ADP
admet-292	163	15	drug	drug	NOUN
admet-292	163	16	salt	salt	NOUN
admet-292	163	17	solubility	solubility	NOUN
admet-292	163	18	(	(	PUNCT
admet-292	163	19	ph	ph	NOUN
admet-292	163	20	2	2	NUM
admet-292	163	21	-	-	SYM
admet-292	163	22	4	4	NUM
admet-292	163	23	)	)	PUNCT
admet-292	163	24	is	be	AUX
admet-292	163	25	:	:	PUNCT
admet-292	163	26	mesylate	mesylate	NOUN
admet-292	163	27	(	(	PUNCT
admet-292	163	28	23	23	PROPN
admet-292	163	29	mg	mg	PROPN
admet-292	163	30	/	/	SYM
admet-292	163	31	ml	ml	NOUN
admet-292	163	32	)	)	PUNCT
admet-292	163	33	>	>	X
admet-292	163	34	chloride	chloride	PROPN
admet-292	163	35	(	(	PUNCT
admet-292	163	36	5	5	PROPN
admet-292	163	37	mg	mg	PROPN
admet-292	163	38	/	/	SYM
admet-292	163	39	ml	ml	NOUN
admet-292	163	40	)	)	PUNCT
admet-292	163	41	>	>	X
admet-292	164	1	phosphate	phosphate	NOUN
admet-292	164	2	(	(	PUNCT
admet-292	164	3	3	3	PROPN
admet-292	164	4	mg	mg	PROPN
admet-292	164	5	/	/	SYM
admet-292	164	6	ml	ml	NOUN
admet-292	164	7	)	)	PUNCT
admet-292	164	8	.	.	PUNCT
admet-292	165	1	however	however	ADV
admet-292	165	2	,	,	PUNCT
admet-292	165	3	the	the	DET
admet-292	165	4	order	order	NOUN
admet-292	165	5	of	of	ADP
admet-292	165	6	the	the	DET
admet-292	165	7	negative	negative	ADJ
admet-292	165	8	log	log	NOUN
admet-292	165	9	salt	salt	NOUN
admet-292	165	10	solubility	solubility	NOUN
admet-292	165	11	products	product	NOUN
admet-292	165	12	is	be	AUX
admet-292	165	13	different	different	ADJ
admet-292	165	14	:	:	PUNCT
admet-292	165	15	mesylate	mesylate	NOUN
admet-292	165	16	(	(	PUNCT
admet-292	165	17	2.5	2.5	PROPN
admet-292	165	18	)	)	PUNCT
admet-292	165	19	<	<	X
admet-292	165	20	phosphate	phosphate	NOUN
admet-292	165	21	(	(	PUNCT
admet-292	165	22	3.2	3.2	PROPN
admet-292	165	23	)	)	PUNCT
admet-292	165	24	<	<	X
admet-292	165	25	chloride	chloride	PROPN
admet-292	165	26	(	(	PUNCT
admet-292	165	27	3.5	3.5	PROPN
admet-292	165	28	)	)	PUNCT
admet-292	165	29	.	.	PUNCT
admet-292	166	1	this	this	DET
admet-292	166	2	highlights	highlight	VERB
admet-292	166	3	the	the	DET
admet-292	166	4	notion	notion	NOUN
admet-292	166	5	that	that	SCONJ
admet-292	166	6	salt	salt	NOUN
admet-292	166	7	solubility	solubility	NOUN
admet-292	166	8	is	be	AUX
admet-292	166	9	a	a	DET
admet-292	166	10	conditional	conditional	ADJ
admet-292	166	11	constant	constant	ADJ
admet-292	166	12	,	,	PUNCT
admet-292	166	13	depending	depend	VERB
admet-292	166	14	on	on	ADP
admet-292	166	15	the	the	DET
admet-292	166	16	concentrations	concentration	NOUN
admet-292	166	17	of	of	ADP
admet-292	166	18	both	both	CCONJ
admet-292	166	19	the	the	DET
admet-292	166	20	drug	drug	NOUN
admet-292	166	21	and	and	CCONJ
admet-292	166	22	the	the	DET
admet-292	166	23	counterion	counterion	NOUN
admet-292	166	24	,	,	PUNCT
admet-292	166	25	whereas	whereas	SCONJ
admet-292	166	26	the	the	DET
admet-292	166	27	salt	salt	NOUN
admet-292	166	28	solubility	solubility	NOUN
admet-292	166	29	product	product	NOUN
admet-292	166	30	is	be	AUX
admet-292	166	31	a	a	DET
admet-292	166	32	true	true	ADJ
admet-292	166	33	equilibrium	equilibrium	NOUN
admet-292	166	34	constant	constant	ADJ
admet-292	166	35	.	.	PUNCT
admet-292	167	1	as	as	SCONJ
admet-292	167	2	is	be	AUX
admet-292	167	3	evident	evident	ADJ
admet-292	167	4	,	,	PUNCT
admet-292	167	5	the	the	DET
admet-292	167	6	interesting	interesting	ADJ
admet-292	167	7	haloperidol	haloperidol	NOUN
admet-292	167	8	case	case	NOUN
admet-292	167	9	study	study	NOUN
admet-292	167	10	invokes	invoke	VERB
admet-292	167	11	several	several	ADJ
admet-292	167	12	issues	issue	NOUN
admet-292	167	13	where	where	SCONJ
admet-292	167	14	experimental	experimental	ADJ
admet-292	167	15	design	design	NOUN
admet-292	167	16	has	have	VERB
admet-292	167	17	significant	significant	ADJ
admet-292	167	18	consequences	consequence	NOUN
admet-292	167	19	:	:	PUNCT
admet-292	167	20	titrant	titrant	NOUN
admet-292	167	21	used	use	VERB
admet-292	167	22	to	to	PART
admet-292	167	23	adjust	adjust	VERB
admet-292	167	24	ph	ph	VERB
admet-292	167	25	,	,	PUNCT
admet-292	167	26	electrode	electrode	NOUN
admet-292	167	27	calibration	calibration	NOUN
admet-292	167	28	,	,	PUNCT
admet-292	167	29	supersaturation	supersaturation	NOUN
admet-292	167	30	,	,	PUNCT
admet-292	167	31	and	and	CCONJ
admet-292	167	32	possibly	possibly	ADV
admet-292	167	33	aggregation	aggregation	NOUN
admet-292	167	34	(	(	PUNCT
admet-292	167	35	or	or	CCONJ
admet-292	167	36	related	related	ADJ
admet-292	167	37	phenomena	phenomenon	NOUN
admet-292	167	38	)	)	PUNCT
admet-292	167	39	.	.	PUNCT
admet-292	168	1	thiazolyloxamic	thiazolyloxamic	PROPN
admet-292	168	2	acid	acid	PROPN
admet-292	168	3	derivative	derivative	ADJ
admet-292	168	4	figure	figure	NOUN
admet-292	168	5	4	4	NUM
admet-292	168	6	shows	show	VERB
admet-292	168	7	a	a	DET
admet-292	168	8	very	very	ADV
admet-292	168	9	complex	complex	ADJ
admet-292	168	10	solubility	solubility	NOUN
admet-292	168	11	-	-	PUNCT
admet-292	168	12	ph	ph	NOUN
admet-292	168	13	profile	profile	NOUN
admet-292	168	14	of	of	ADP
admet-292	168	15	a	a	DET
admet-292	168	16	surface	surface	NOUN
admet-292	168	17	-	-	PUNCT
admet-292	168	18	active	active	ADJ
admet-292	168	19	weak	weak	ADJ
admet-292	168	20	acid	acid	NOUN
admet-292	168	21	,	,	PUNCT
admet-292	168	22	n-[4-(1,4	n-[4-(1,4	ADJ
admet-292	168	23	-	-	PUNCT
admet-292	168	24	benzodioxan-6yl)-2	benzodioxan-6yl)-2	ADV
admet-292	168	25	-	-	PUNCT
admet-292	168	26	thiazolyl]oxamic	thiazolyl]oxamic	ADJ
admet-292	168	27	acid	acid	NOUN
admet-292	168	28	,	,	PUNCT
admet-292	168	29	which	which	PRON
admet-292	168	30	has	have	VERB
admet-292	168	31	two	two	NUM
admet-292	168	32	pkas	pkas	NOUN
admet-292	168	33	:	:	PUNCT
admet-292	168	34	1.32	1.32	NUM
admet-292	168	35	and	and	CCONJ
admet-292	168	36	10.31	10.31	NUM
admet-292	168	37	,	,	PUNCT
admet-292	168	38	both	both	PRON
admet-292	168	39	determined	determine	VERB
admet-292	168	40	spectrophotometrically	spectrophotometrically	ADV
admet-292	168	41	[	[	X
admet-292	168	42	6	6	NUM
admet-292	168	43	]	]	PUNCT
admet-292	168	44	.	.	PUNCT
admet-292	169	1	it	it	PRON
admet-292	169	2	is	be	AUX
admet-292	169	3	an	an	DET
admet-292	169	4	example	example	NOUN
admet-292	169	5	of	of	ADP
admet-292	169	6	a	a	DET
admet-292	169	7	molecule	molecule	NOUN
admet-292	169	8	,	,	PUNCT
admet-292	169	9	when	when	SCONJ
admet-292	169	10	added	add	VERB
admet-292	169	11	as	as	ADP
admet-292	169	12	a	a	DET
admet-292	169	13	salt	salt	NOUN
admet-292	169	14	,	,	PUNCT
admet-292	169	15	that	that	PRON
admet-292	169	16	becomes	become	VERB
admet-292	169	17	more	more	ADV
admet-292	169	18	soluble	soluble	ADJ
admet-292	169	19	as	as	SCONJ
admet-292	169	20	more	more	ADJ
admet-292	169	21	of	of	ADP
admet-292	169	22	it	it	PRON
admet-292	169	23	is	be	AUX
admet-292	169	24	added	add	VERB
admet-292	169	25	to	to	ADP
admet-292	169	26	solution	solution	NOUN
admet-292	169	27	,	,	PUNCT
admet-292	169	28	somewhat	somewhat	ADV
admet-292	169	29	like	like	ADP
admet-292	169	30	the	the	DET
admet-292	169	31	case	case	NOUN
admet-292	169	32	of	of	ADP
admet-292	169	33	amiodarone	amiodarone	NOUN
admet-292	169	34	[	[	X
admet-292	169	35	24	24	NUM
admet-292	169	36	]	]	PUNCT
admet-292	169	37	.	.	PUNCT
admet-292	170	1	the	the	DET
admet-292	170	2	prominent	prominent	ADJ
admet-292	170	3	“	"	PUNCT
admet-292	170	4	bump	bump	NOUN
admet-292	170	5	”	"	PUNCT
admet-292	170	6	in	in	ADP
admet-292	170	7	the	the	DET
admet-292	170	8	logs	log	NOUN
admet-292	170	9	-	-	PUNCT
admet-292	170	10	ph	ph	ADJ
admet-292	170	11	profile	profile	NOUN
admet-292	170	12	is	be	AUX
admet-292	170	13	consistent	consistent	ADJ
admet-292	170	14	with	with	ADP
admet-292	170	15	the	the	DET
admet-292	170	16	formation	formation	NOUN
admet-292	170	17	of	of	ADP
admet-292	170	18	a	a	DET
admet-292	170	19	hexameric	hexameric	NOUN
admet-292	170	20	anionic	anionic	NOUN
admet-292	170	21	aggregate	aggregate	NOUN
admet-292	170	22	,	,	PUNCT
admet-292	170	23	(	(	PUNCT
admet-292	170	24	ha–)6	ha–)6	NOUN
admet-292	170	25	.	.	PUNCT
admet-292	171	1	the	the	DET
admet-292	171	2	solubility	solubility	NOUN
admet-292	171	3	of	of	ADP
admet-292	171	4	the	the	DET
admet-292	171	5	ethanolamine	ethanolamine	NOUN
admet-292	171	6	salt	salt	NOUN
admet-292	171	7	in	in	ADP
admet-292	171	8	the	the	DET
admet-292	171	9	neutral	neutral	ADJ
admet-292	171	10	ph	ph	NOUN
admet-292	171	11	region	region	NOUN
admet-292	171	12	is	be	AUX
admet-292	171	13	20.3	20.3	NUM
admet-292	171	14	mg	mg	NOUN
admet-292	171	15	/	/	SYM
admet-292	171	16	ml	ml	PROPN
admet-292	172	1	(	(	PUNCT
admet-292	172	2	pksp	pksp	NOUN
admet-292	172	3	4.22	4.22	NUM
admet-292	172	4	)	)	PUNCT
admet-292	172	5	.	.	PUNCT
admet-292	173	1	since	since	SCONJ
admet-292	173	2	aggregation	aggregation	NOUN
admet-292	173	3	is	be	AUX
admet-292	173	4	strongly	strongly	ADV
admet-292	173	5	dependent	dependent	ADJ
admet-292	173	6	on	on	ADP
admet-292	173	7	concentration	concentration	NOUN
admet-292	173	8	,	,	PUNCT
admet-292	173	9	in	in	ADP
admet-292	173	10	the	the	DET
admet-292	173	11	absence	absence	NOUN
admet-292	173	12	of	of	ADP
admet-292	173	13	aggregation	aggregation	NOUN
admet-292	173	14	(	(	PUNCT
admet-292	173	15	i.e.	i.e.	X
admet-292	173	16	,	,	PUNCT
admet-292	173	17	at	at	ADP
admet-292	173	18	lower	low	ADJ
admet-292	173	19	concentrations	concentration	NOUN
admet-292	173	20	)	)	PUNCT
admet-292	173	21	,	,	PUNCT
admet-292	173	22	the	the	DET
admet-292	173	23	salt	salt	NOUN
admet-292	173	24	solubility	solubility	NOUN
admet-292	173	25	would	would	AUX
admet-292	173	26	be	be	AUX
admet-292	173	27	predicted	predict	VERB
admet-292	173	28	to	to	PART
admet-292	173	29	be	be	AUX
admet-292	173	30	2.0	2.0	NUM
admet-292	173	31	mg	mg	NOUN
admet-292	173	32	/	/	SYM
admet-292	173	33	ml	ml	PROPN
admet-292	173	34	(	(	PUNCT
admet-292	173	35	simulated	simulate	VERB
admet-292	173	36	blue	blue	ADJ
admet-292	173	37	curve	curve	NOUN
admet-292	173	38	in	in	ADP
admet-292	173	39	figure	figure	NOUN
admet-292	173	40	4a	4a	NUM
admet-292	173	41	)	)	PUNCT
admet-292	173	42	.	.	PUNCT
admet-292	174	1	here	here	ADV
admet-292	174	2	,	,	PUNCT
admet-292	174	3	salt	salt	NOUN
admet-292	174	4	solubility	solubility	NOUN
admet-292	174	5	depends	depend	VERB
admet-292	174	6	not	not	PART
admet-292	174	7	only	only	ADV
admet-292	174	8	on	on	ADP
admet-292	174	9	the	the	DET
admet-292	174	10	amount	amount	NOUN
admet-292	174	11	of	of	ADP
admet-292	174	12	ethanolamine	ethanolamine	NOUN
admet-292	174	13	but	but	CCONJ
admet-292	174	14	also	also	ADV
admet-292	174	15	the	the	DET
admet-292	174	16	amount	amount	NOUN
admet-292	174	17	of	of	ADP
admet-292	174	18	the	the	DET
admet-292	174	19	conjugate	conjugate	ADJ
admet-292	174	20	anion	anion	NOUN
admet-292	174	21	,	,	PUNCT
admet-292	174	22	which	which	PRON
admet-292	174	23	in	in	ADP
admet-292	174	24	turn	turn	NOUN
admet-292	174	25	is	be	AUX
admet-292	174	26	affected	affect	VERB
admet-292	174	27	by	by	ADP
admet-292	174	28	the	the	DET
admet-292	174	29	extent	extent	NOUN
admet-292	174	30	of	of	ADP
admet-292	174	31	aggregation	aggregation	NOUN
admet-292	174	32	.	.	PUNCT
admet-292	175	1	pandit	pandit	PROPN
admet-292	175	2	et	et	PROPN
admet-292	175	3	al	al	PROPN
admet-292	175	4	.	.	PUNCT
admet-292	176	1	[	[	X
admet-292	176	2	6	6	NUM
admet-292	176	3	]	]	PUNCT
admet-292	176	4	also	also	ADV
admet-292	176	5	studied	study	VERB
admet-292	176	6	other	other	ADJ
admet-292	176	7	salt	salt	NOUN
admet-292	176	8	-	-	PUNCT
admet-292	176	9	forming	form	VERB
admet-292	176	10	counterions	counterion	NOUN
admet-292	176	11	,	,	PUNCT
admet-292	176	12	besides	besides	SCONJ
admet-292	176	13	ethanolamine	ethanolamine	NOUN
admet-292	176	14	.	.	PUNCT
admet-292	177	1	figure	figure	NOUN
admet-292	177	2	4a	4a	NOUN
admet-292	177	3	shows	show	VERB
admet-292	177	4	the	the	DET
admet-292	177	5	calcium	calcium	NOUN
admet-292	177	6	salt	salt	NOUN
admet-292	177	7	solubility	solubility	NOUN
admet-292	177	8	(	(	PUNCT
admet-292	177	9	dash	dash	NOUN
admet-292	177	10	-	-	PUNCT
admet-292	177	11	dot	dot	NOUN
admet-292	177	12	curve	curve	NOUN
admet-292	177	13	)	)	PUNCT
admet-292	177	14	.	.	PUNCT
admet-292	178	1	the	the	DET
admet-292	178	2	calcium	calcium	NOUN
admet-292	178	3	salt	salt	NOUN
admet-292	178	4	is	be	AUX
admet-292	178	5	quite	quite	DET
admet-292	178	6	a	a	DET
admet-292	178	7	bit	bit	NOUN
admet-292	178	8	less	less	ADV
admet-292	178	9	soluble	soluble	ADJ
admet-292	178	10	than	than	ADP
admet-292	178	11	the	the	DET
admet-292	178	12	one	one	NUM
admet-292	178	13	based	base	VERB
admet-292	178	14	on	on	ADP
admet-292	178	15	ethanolamine	ethanolamine	NOUN
admet-292	178	16	.	.	PUNCT
admet-292	179	1	for	for	ADP
admet-292	179	2	the	the	DET
admet-292	179	3	case	case	NOUN
admet-292	179	4	of	of	ADP
admet-292	179	5	calcium	calcium	NOUN
admet-292	179	6	,	,	PUNCT
admet-292	179	7	the	the	DET
admet-292	179	8	impact	impact	NOUN
admet-292	179	9	of	of	ADP
admet-292	179	10	aggregation	aggregation	NOUN
admet-292	179	11	is	be	AUX
admet-292	179	12	much	much	ADV
admet-292	179	13	lessened	lessen	VERB
admet-292	179	14	,	,	PUNCT
admet-292	179	15	as	as	SCONJ
admet-292	179	16	is	be	AUX
admet-292	179	17	suggested	suggest	VERB
admet-292	179	18	in	in	ADP
admet-292	179	19	figure	figure	NOUN
admet-292	179	20	4a	4a	NOUN
admet-292	179	21	.	.	PUNCT
admet-292	180	1	alex	alex	PROPN
admet-292	180	2	avdeef	avdeef	PROPN
admet-292	180	3	et	et	PROPN
admet-292	180	4	al	al	PROPN
admet-292	180	5	.	.	PROPN
admet-292	180	6	admet	admet	PROPN
admet-292	180	7	&	&	CCONJ
admet-292	180	8	dmpk	dmpk	PROPN
admet-292	180	9	4(2	4(2	NUM
admet-292	180	10	)	)	PUNCT
admet-292	180	11	(	(	PUNCT
admet-292	180	12	2016	2016	NUM
admet-292	180	13	)	)	PUNCT
admet-292	180	14	117	117	NUM
admet-292	180	15	-	-	SYM
admet-292	180	16	178	178	NUM
admet-292	180	17	126	126	NUM
admet-292	180	18	figure	figure	NOUN
admet-292	180	19	4	4	NUM
admet-292	180	20	.	.	PUNCT
admet-292	180	21	n-[4-(1,4	n-[4-(1,4	ADJ
admet-292	180	22	-	-	PUNCT
admet-292	180	23	benzodioxan-6	benzodioxan-6	ADP
admet-292	180	24	-	-	PUNCT
admet-292	180	25	yl)-2	yl)-2	NOUN
admet-292	180	26	-	-	PUNCT
admet-292	180	27	thiazolyl]oxamic	thiazolyl]oxamic	ADJ
admet-292	180	28	acid	acid	NOUN
admet-292	180	29	as	as	ADP
admet-292	180	30	an	an	DET
admet-292	180	31	example	example	NOUN
admet-292	180	32	of	of	ADP
admet-292	180	33	complexity	complexity	NOUN
admet-292	180	34	of	of	ADP
admet-292	180	35	logs	log	NOUN
admet-292	180	36	-	-	PUNCT
admet-292	180	37	ph	ph	ADJ
admet-292	180	38	profiles	profile	NOUN
admet-292	180	39	of	of	ADP
admet-292	180	40	surface	surface	NOUN
admet-292	180	41	-	-	PUNCT
admet-292	180	42	active	active	ADJ
admet-292	180	43	molecules	molecule	NOUN
admet-292	180	44	which	which	PRON
admet-292	180	45	precipitate	precipitate	VERB
admet-292	180	46	both	both	PRON
admet-292	180	47	as	as	ADP
admet-292	180	48	salts	salt	NOUN
admet-292	180	49	and	and	CCONJ
admet-292	180	50	as	as	ADP
admet-292	180	51	uncharged	uncharged	ADJ
admet-292	180	52	species	specie	NOUN
admet-292	180	53	.	.	PUNCT
admet-292	181	1	another	another	DET
admet-292	181	2	interesting	interesting	ADJ
admet-292	181	3	feature	feature	NOUN
admet-292	181	4	of	of	ADP
admet-292	181	5	the	the	DET
admet-292	181	6	oxamic	oxamic	ADJ
admet-292	181	7	acid	acid	NOUN
admet-292	181	8	derivative	derivative	NOUN
admet-292	181	9	solubility	solubility	NOUN
admet-292	181	10	profile	profile	NOUN
admet-292	181	11	is	be	AUX
admet-292	181	12	that	that	SCONJ
admet-292	181	13	between	between	ADP
admet-292	181	14	ph	ph	PROPN
admet-292	181	15	2.5	2.5	NUM
admet-292	181	16	and	and	CCONJ
admet-292	181	17	3.5	3.5	NUM
admet-292	181	18	,	,	PUNCT
admet-292	181	19	the	the	DET
admet-292	181	20	free	free	ADJ
admet-292	181	21	acid	acid	NOUN
admet-292	181	22	,	,	PUNCT
admet-292	181	23	h2a(s	h2a(s	PROPN
admet-292	181	24	)	)	PUNCT
admet-292	181	25	,	,	PUNCT
admet-292	181	26	and	and	CCONJ
admet-292	181	27	the	the	DET
admet-292	181	28	ethanolamine	ethanolamine	NOUN
admet-292	181	29	salt	salt	NOUN
admet-292	181	30	,	,	PUNCT
admet-292	181	31	[	[	X
admet-292	181	32	ha	ha	INTJ
admet-292	181	33	.(ethanolamine)h	.(ethanolamine)h	PUNCT
admet-292	182	1	+	+	X
admet-292	182	2	]	]	X
admet-292	182	3	(	(	PUNCT
admet-292	182	4	s	s	NOUN
admet-292	182	5	)	)	PUNCT
admet-292	182	6	,	,	PUNCT
admet-292	182	7	co	co	NOUN
admet-292	182	8	-	-	NOUN
admet-292	182	9	precipitate	precipitate	ADJ
admet-292	182	10	.	.	PUNCT
admet-292	183	1	figure	figure	NOUN
admet-292	183	2	4b	4b	PROPN
admet-292	183	3	identifies	identify	VERB
admet-292	183	4	three	three	NUM
admet-292	183	5	solid	solid	ADJ
admet-292	183	6	phase	phase	NOUN
admet-292	183	7	regions	region	NOUN
admet-292	183	8	,	,	PUNCT
admet-292	183	9	with	with	ADP
admet-292	183	10	boundaries	boundary	NOUN
admet-292	183	11	delimited	delimit	VERB
admet-292	183	12	by	by	ADP
admet-292	183	13	thin	thin	ADJ
admet-292	183	14	vertical	vertical	ADJ
admet-292	183	15	lines	line	NOUN
admet-292	183	16	.	.	PUNCT
admet-292	184	1	below	below	ADP
admet-292	184	2	ph	ph	PROPN
admet-292	184	3	2.5	2.5	NUM
admet-292	184	4	,	,	PUNCT
admet-292	184	5	only	only	ADV
admet-292	184	6	the	the	DET
admet-292	184	7	free	free	ADJ
admet-292	184	8	acid	acid	NOUN
admet-292	184	9	precipitates	precipitate	NOUN
admet-292	184	10	.	.	PUNCT
admet-292	185	1	above	above	ADP
admet-292	185	2	ph	ph	X
admet-292	185	3	3.5	3.5	NUM
admet-292	185	4	,	,	PUNCT
admet-292	185	5	only	only	ADV
admet-292	185	6	the	the	DET
admet-292	185	7	ethanolamine	ethanolamine	NOUN
admet-292	185	8	salt	salt	NOUN
admet-292	185	9	of	of	ADP
admet-292	185	10	the	the	DET
admet-292	185	11	drug	drug	NOUN
admet-292	185	12	precipitates	precipitate	NOUN
admet-292	185	13	.	.	PUNCT
admet-292	186	1	between	between	ADP
admet-292	186	2	the	the	DET
admet-292	186	3	two	two	NUM
admet-292	186	4	boundaries	boundary	NOUN
admet-292	186	5	,	,	PUNCT
admet-292	186	6	both	both	DET
admet-292	186	7	solids	solid	NOUN
admet-292	186	8	co	co	NOUN
admet-292	186	9	-	-	NOUN
admet-292	186	10	precipitate	precipitate	ADJ
admet-292	186	11	.	.	PUNCT
admet-292	187	1	a	a	DET
admet-292	187	2	rationalization	rationalization	NOUN
admet-292	187	3	of	of	ADP
admet-292	187	4	this	this	DET
admet-292	187	5	phenomenon	phenomenon	NOUN
admet-292	187	6	is	be	AUX
admet-292	187	7	that	that	SCONJ
admet-292	187	8	while	while	SCONJ
admet-292	187	9	there	there	PRON
admet-292	187	10	is	be	VERB
admet-292	187	11	sufficient	sufficient	ADJ
admet-292	187	12	amount	amount	NOUN
admet-292	187	13	of	of	ADP
admet-292	187	14	the	the	DET
admet-292	187	15	acid	acid	NOUN
admet-292	187	16	present	present	NOUN
admet-292	187	17	to	to	PART
admet-292	187	18	form	form	VERB
admet-292	187	19	a	a	DET
admet-292	187	20	precipitate	precipitate	NOUN
admet-292	187	21	,	,	PUNCT
admet-292	187	22	there	there	PRON
admet-292	187	23	is	be	VERB
admet-292	187	24	simultaneously	simultaneously	ADV
admet-292	187	25	enough	enough	ADJ
admet-292	187	26	of	of	ADP
admet-292	187	27	the	the	DET
admet-292	187	28	negatively	negatively	ADV
admet-292	187	29	-	-	PUNCT
admet-292	187	30	charged	charge	VERB
admet-292	187	31	acid	acid	NOUN
admet-292	187	32	and	and	CCONJ
admet-292	187	33	the	the	DET
admet-292	187	34	positively	positively	ADV
admet-292	187	35	-	-	PUNCT
admet-292	187	36	charge	charge	NOUN
admet-292	187	37	ethanolamine	ethanolamine	NOUN
admet-292	187	38	to	to	PART
admet-292	187	39	exceed	exceed	VERB
admet-292	187	40	the	the	DET
admet-292	187	41	solubility	solubility	NOUN
admet-292	187	42	product	product	NOUN
admet-292	187	43	,	,	PUNCT
admet-292	187	44	to	to	PART
admet-292	187	45	result	result	VERB
admet-292	187	46	in	in	ADP
admet-292	187	47	the	the	DET
admet-292	187	48	simultaneous	simultaneous	ADJ
admet-292	187	49	formation	formation	NOUN
admet-292	187	50	of	of	ADP
admet-292	187	51	the	the	DET
admet-292	187	52	second	second	ADJ
admet-292	187	53	solid	solid	NOUN
admet-292	187	54	.	.	PUNCT
admet-292	188	1	the	the	DET
admet-292	188	2	presence	presence	NOUN
admet-292	188	3	of	of	ADP
admet-292	188	4	the	the	DET
admet-292	188	5	hexamer	hexamer	NOUN
admet-292	188	6	(	(	PUNCT
admet-292	188	7	thick	thick	ADJ
admet-292	188	8	solid	solid	ADJ
admet-292	188	9	line	line	NOUN
admet-292	188	10	in	in	ADP
admet-292	188	11	figure	figure	NOUN
admet-292	188	12	4b	4b	X
admet-292	188	13	)	)	PUNCT
admet-292	188	14	mitigates	mitigate	VERB
admet-292	188	15	the	the	DET
admet-292	188	16	process	process	NOUN
admet-292	188	17	,	,	PUNCT
admet-292	188	18	since	since	SCONJ
admet-292	188	19	a	a	DET
admet-292	188	20	lot	lot	NOUN
admet-292	188	21	of	of	ADP
admet-292	188	22	the	the	DET
admet-292	188	23	negatively	negatively	ADV
admet-292	188	24	-	-	PUNCT
admet-292	188	25	charged	charge	VERB
admet-292	188	26	acid	acid	NOUN
admet-292	188	27	is	be	AUX
admet-292	188	28	tied	tie	VERB
admet-292	188	29	up	up	ADP
admet-292	188	30	simultaneously	simultaneously	ADV
admet-292	188	31	in	in	ADP
admet-292	188	32	the	the	DET
admet-292	188	33	aggregate	aggregate	NOUN
admet-292	188	34	.	.	PUNCT
admet-292	189	1	acetylpromazine	acetylpromazine	ADJ
admet-292	189	2	figure	figure	NOUN
admet-292	189	3	5	5	NUM
admet-292	189	4	is	be	AUX
admet-292	189	5	an	an	DET
admet-292	189	6	example	example	NOUN
admet-292	189	7	of	of	ADP
admet-292	189	8	the	the	DET
admet-292	189	9	speciation	speciation	NOUN
admet-292	189	10	of	of	ADP
admet-292	189	11	acetylpromazine	acetylpromazine	ADJ
admet-292	189	12	maleate	maleate	NOUN
admet-292	189	13	,	,	PUNCT
admet-292	189	14	a	a	DET
admet-292	189	15	weak	weak	ADJ
admet-292	189	16	base	base	NOUN
admet-292	189	17	with	with	ADP
admet-292	189	18	a	a	DET
admet-292	189	19	reported	report	VERB
admet-292	189	20	critical	critical	ADJ
admet-292	189	21	micelle	micelle	NOUN
admet-292	189	22	concentration	concentration	NOUN
admet-292	189	23	of	of	ADP
admet-292	189	24	12	12	NUM
admet-292	189	25	mm	mm	NOUN
admet-292	190	1	[	[	X
admet-292	190	2	62	62	NUM
admet-292	190	3	]	]	PUNCT
admet-292	190	4	.	.	PUNCT
admet-292	191	1	the	the	DET
admet-292	191	2	traditional	traditional	ADJ
admet-292	191	3	view	view	NOUN
admet-292	191	4	of	of	ADP
admet-292	191	5	simple	simple	ADJ
admet-292	191	6	ionic	ionic	ADJ
admet-292	191	7	detergents	detergent	NOUN
admet-292	191	8	is	be	AUX
admet-292	191	9	that	that	SCONJ
admet-292	191	10	as	as	ADP
admet-292	191	11	the	the	DET
admet-292	191	12	concentration	concentration	NOUN
admet-292	191	13	of	of	ADP
admet-292	191	14	added	add	VERB
admet-292	191	15	surfactant	surfactant	ADJ
admet-292	191	16	increases	increase	NOUN
admet-292	191	17	,	,	PUNCT
admet-292	191	18	monomers	monomer	NOUN
admet-292	191	19	form	form	VERB
admet-292	191	20	until	until	SCONJ
admet-292	191	21	the	the	DET
admet-292	191	22	cmc	cmc	NOUN
admet-292	191	23	is	be	AUX
admet-292	191	24	exceeded	exceed	VERB
admet-292	191	25	.	.	PUNCT
admet-292	192	1	further	further	ADJ
admet-292	192	2	increases	increase	NOUN
admet-292	192	3	of	of	ADP
admet-292	192	4	the	the	DET
admet-292	192	5	surfactant	surfactant	ADJ
admet-292	192	6	lead	lead	NOUN
admet-292	192	7	to	to	ADP
admet-292	192	8	the	the	DET
admet-292	192	9	formation	formation	NOUN
admet-292	192	10	of	of	ADP
admet-292	192	11	micelles	micelle	NOUN
admet-292	192	12	with	with	ADP
admet-292	192	13	aggregation	aggregation	NOUN
admet-292	192	14	numbers	number	NOUN
admet-292	192	15	reaching	reach	VERB
admet-292	192	16	50	50	NUM
admet-292	192	17	or	or	CCONJ
admet-292	192	18	higher	high	ADJ
admet-292	192	19	,	,	PUNCT
admet-292	192	20	whose	whose	DET
admet-292	192	21	concentration	concentration	NOUN
admet-292	192	22	increases	increase	NOUN
admet-292	192	23	,	,	PUNCT
admet-292	192	24	while	while	SCONJ
admet-292	192	25	that	that	PRON
admet-292	192	26	of	of	ADP
admet-292	192	27	the	the	DET
admet-292	192	28	monomer	monomer	NOUN
admet-292	192	29	remains	remain	VERB
admet-292	192	30	constant	constant	ADJ
admet-292	192	31	.	.	PUNCT
admet-292	193	1	with	with	ADP
admet-292	193	2	ionizable	ionizable	ADJ
admet-292	193	3	drug	drug	NOUN
admet-292	193	4	molecules	molecule	NOUN
admet-292	193	5	that	that	PRON
admet-292	193	6	have	have	VERB
admet-292	193	7	surfactant	surfactant	ADJ
admet-292	193	8	properties	property	NOUN
admet-292	193	9	,	,	PUNCT
admet-292	193	10	the	the	DET
admet-292	193	11	picture	picture	NOUN
admet-292	193	12	can	can	AUX
admet-292	193	13	be	be	AUX
admet-292	193	14	more	more	ADV
admet-292	193	15	complicated	complicated	ADJ
admet-292	193	16	,	,	PUNCT
admet-292	193	17	as	as	SCONJ
admet-292	193	18	illustrated	illustrate	VERB
admet-292	193	19	in	in	ADP
admet-292	193	20	figure	figure	NOUN
admet-292	193	21	5	5	NUM
admet-292	193	22	.	.	PUNCT
admet-292	194	1	the	the	DET
admet-292	194	2	water	water	NOUN
admet-292	194	3	-	-	PUNCT
admet-292	194	4	soluble	soluble	ADJ
admet-292	194	5	sub	sub	ADJ
admet-292	194	6	-	-	ADJ
admet-292	194	7	micellar	micellar	ADJ
admet-292	194	8	aggregate	aggregate	NOUN
admet-292	194	9	,	,	PUNCT
admet-292	194	10	(	(	PUNCT
admet-292	194	11	b9h7	b9h7	NOUN
admet-292	194	12	)	)	PUNCT
admet-292	194	13	7	7	NUM
admet-292	194	14	+	+	CCONJ
admet-292	194	15	best	good	ADJ
admet-292	194	16	fits	fit	VERB
admet-292	194	17	the	the	DET
admet-292	194	18	“	"	PUNCT
admet-292	194	19	bump	bump	NOUN
admet-292	194	20	”	"	PUNCT
admet-292	194	21	portion	portion	NOUN
admet-292	194	22	of	of	ADP
admet-292	194	23	the	the	DET
admet-292	194	24	logs	log	NOUN
admet-292	194	25	-	-	PUNCT
admet-292	194	26	ph	ph	ADJ
admet-292	194	27	profile	profile	NOUN
admet-292	194	28	.	.	PUNCT
admet-292	195	1	the	the	DET
admet-292	195	2	concentration	concentration	NOUN
admet-292	195	3	of	of	ADP
admet-292	195	4	the	the	DET
admet-292	195	5	monomer	monomer	NOUN
admet-292	195	6	does	do	AUX
admet-292	195	7	not	not	PART
admet-292	195	8	remain	remain	VERB
admet-292	195	9	constant	constant	ADJ
admet-292	195	10	,	,	PUNCT
admet-292	195	11	and	and	CCONJ
admet-292	195	12	that	that	PRON
admet-292	195	13	of	of	ADP
admet-292	195	14	the	the	DET
admet-292	195	15	aggregate	aggregate	ADJ
admet-292	195	16	formation	formation	NOUN
admet-292	195	17	strongly	strongly	ADV
admet-292	195	18	depends	depend	VERB
admet-292	195	19	on	on	ADP
admet-292	195	20	ph	ph	VERB
admet-292	195	21	,	,	PUNCT
admet-292	195	22	as	as	SCONJ
admet-292	195	23	shown	show	VERB
admet-292	195	24	in	in	ADP
admet-292	195	25	figure	figure	NOUN
admet-292	195	26	5b	5b	NUM
admet-292	195	27	.	.	PUNCT
admet-292	196	1	ion	ion	NOUN
admet-292	196	2	-	-	PUNCT
admet-292	196	3	pair	pair	NOUN
admet-292	196	4	interactions	interaction	NOUN
admet-292	196	5	between	between	ADP
admet-292	196	6	chloride	chloride	NOUN
admet-292	196	7	and	and	CCONJ
admet-292	196	8	the	the	DET
admet-292	196	9	protonated	protonated	ADJ
admet-292	196	10	form	form	NOUN
admet-292	196	11	of	of	ADP
admet-292	196	12	acetylpromazine	acetylpromazine	NOUN
admet-292	196	13	are	be	AUX
admet-292	196	14	also	also	ADV
admet-292	196	15	suggested	suggest	VERB
admet-292	196	16	at	at	ADP
admet-292	196	17	low	low	ADJ
admet-292	196	18	ph	ph	PROPN
admet-292	196	19	.	.	PUNCT
admet-292	197	1	there	there	PRON
admet-292	197	2	may	may	AUX
admet-292	197	3	be	be	AUX
admet-292	197	4	neutral	neutral	ADJ
admet-292	197	5	aggregates	aggregate	NOUN
admet-292	197	6	above	above	ADP
admet-292	197	7	ph	ph	X
admet-292	197	8	8	8	NUM
admet-292	197	9	(	(	PUNCT
admet-292	197	10	case	case	NOUN
admet-292	197	11	1b	1b	NUM
admet-292	197	12	in	in	ADP
admet-292	197	13	[	[	X
admet-292	197	14	27	27	NUM
admet-292	197	15	]	]	NUM
admet-292	197	16	)	)	PUNCT
admet-292	197	17	.	.	PUNCT
admet-292	198	1	for	for	ADP
admet-292	198	2	additional	additional	ADJ
admet-292	198	3	characteristics	characteristic	NOUN
admet-292	198	4	of	of	ADP
admet-292	198	5	the	the	DET
admet-292	198	6	fascinating	fascinating	ADJ
admet-292	198	7	properties	property	NOUN
admet-292	198	8	of	of	ADP
admet-292	198	9	acetylpromazine	acetylpromazine	ADJ
admet-292	198	10	maleate	maleate	NOUN
admet-292	198	11	,	,	PUNCT
admet-292	198	12	a	a	DET
admet-292	198	13	close	close	ADJ
admet-292	198	14	inspection	inspection	NOUN
admet-292	198	15	of	of	ADP
admet-292	198	16	the	the	DET
admet-292	198	17	analysis	analysis	NOUN
admet-292	198	18	detail	detail	NOUN
admet-292	198	19	summarized	summarize	VERB
admet-292	198	20	in	in	ADP
admet-292	198	21	figures	figure	NOUN
admet-292	198	22	5a	5a	NUM
admet-292	198	23	and	and	CCONJ
admet-292	198	24	5b	5b	NUM
admet-292	198	25	,	,	PUNCT
admet-292	198	26	and	and	CCONJ
admet-292	198	27	a	a	DET
admet-292	198	28	review	review	NOUN
admet-292	198	29	of	of	ADP
admet-292	198	30	the	the	DET
admet-292	198	31	paper	paper	NOUN
admet-292	198	32	by	by	ADP
admet-292	198	33	liu	liu	PROPN
admet-292	198	34	and	and	CCONJ
admet-292	198	35	hurwitz	hurwitz	PROPN
admet-292	199	1	[	[	X
admet-292	199	2	62	62	NUM
admet-292	199	3	]	]	PUNCT
admet-292	199	4	is	be	AUX
admet-292	199	5	recommended	recommend	VERB
admet-292	199	6	.	.	PUNCT
admet-292	200	1	admet	admet	PROPN
admet-292	200	2	&	&	CCONJ
admet-292	200	3	dmpk	dmpk	PROPN
admet-292	200	4	4(2	4(2	NUM
admet-292	200	5	)	)	PUNCT
admet-292	200	6	(	(	PUNCT
admet-292	200	7	2016	2016	NUM
admet-292	200	8	)	)	PUNCT
admet-292	200	9	117	117	NUM
admet-292	200	10	-	-	SYM
admet-292	200	11	178	178	NUM
admet-292	200	12	consensus	consensus	NOUN
admet-292	200	13	recommendations	recommendation	NOUN
admet-292	200	14	for	for	ADP
admet-292	200	15	improving	improve	VERB
admet-292	200	16	solubility	solubility	NOUN
admet-292	200	17	-	-	PUNCT
admet-292	200	18	ph	ph	ADJ
admet-292	200	19	data	datum	NOUN
admet-292	200	20	quality	quality	NOUN
admet-292	200	21	doi	doi	NOUN
admet-292	200	22	:	:	PUNCT
admet-292	200	23	10.5599	10.5599	NUM
admet-292	200	24	/	/	SYM
admet-292	200	25	admet.4.2.292	admet.4.2.292	PROPN
admet-292	200	26	127	127	NUM
admet-292	200	27	figure	figure	NOUN
admet-292	200	28	5	5	NUM
admet-292	200	29	.	.	PUNCT
admet-292	200	30	acetylpromazine	acetylpromazine	PROPN
admet-292	200	31	as	as	ADP
admet-292	200	32	an	an	DET
admet-292	200	33	example	example	NOUN
admet-292	200	34	of	of	ADP
admet-292	200	35	the	the	DET
admet-292	200	36	complexity	complexity	NOUN
admet-292	200	37	of	of	ADP
admet-292	200	38	logs	log	NOUN
admet-292	200	39	-	-	PUNCT
admet-292	200	40	ph	ph	ADJ
admet-292	200	41	profiles	profile	NOUN
admet-292	200	42	of	of	ADP
admet-292	200	43	surface	surface	NOUN
admet-292	200	44	-	-	PUNCT
admet-292	200	45	active	active	ADJ
admet-292	200	46	molecules	molecule	NOUN
admet-292	200	47	,	,	PUNCT
admet-292	200	48	suggesting	suggest	VERB
admet-292	200	49	that	that	PRON
admet-292	200	50	care	care	NOUN
admet-292	200	51	needs	need	VERB
admet-292	200	52	to	to	PART
admet-292	200	53	be	be	AUX
admet-292	200	54	exercised	exercise	VERB
admet-292	200	55	in	in	ADP
admet-292	200	56	interpreting	interpret	VERB
admet-292	200	57	the	the	DET
admet-292	200	58	shapes	shape	NOUN
admet-292	200	59	of	of	ADP
admet-292	200	60	the	the	DET
admet-292	200	61	solubility	solubility	NOUN
admet-292	200	62	-	-	PUNCT
admet-292	200	63	ph	ph	ADJ
admet-292	200	64	profiles	profile	NOUN
admet-292	200	65	.	.	PUNCT
admet-292	201	1	summary	summary	NOUN
admet-292	201	2	of	of	ADP
admet-292	201	3	issues	issue	NOUN
admet-292	201	4	raised	raise	VERB
admet-292	201	5	in	in	ADP
admet-292	201	6	the	the	DET
admet-292	201	7	case	case	NOUN
admet-292	201	8	studies	study	VERB
admet-292	201	9	the	the	DET
admet-292	201	10	above	above	ADJ
admet-292	201	11	cases	case	NOUN
admet-292	201	12	were	be	AUX
admet-292	201	13	selected	select	VERB
admet-292	201	14	as	as	ADP
admet-292	201	15	representative	representative	ADJ
admet-292	201	16	examples	example	NOUN
admet-292	201	17	of	of	ADP
admet-292	201	18	apparently	apparently	ADV
admet-292	201	19	well	well	ADV
admet-292	201	20	-	-	PUNCT
admet-292	201	21	designed	design	VERB
admet-292	201	22	assays	assay	NOUN
admet-292	201	23	,	,	PUNCT
admet-292	201	24	which	which	PRON
admet-292	201	25	illustrate	illustrate	VERB
admet-292	201	26	how	how	SCONJ
admet-292	201	27	complicated	complicated	ADJ
admet-292	201	28	heterogeneous	heterogeneous	ADJ
admet-292	201	29	chemical	chemical	NOUN
admet-292	201	30	reactions	reaction	NOUN
admet-292	201	31	involving	involve	VERB
admet-292	201	32	druglike	druglike	NOUN
admet-292	201	33	molecules	molecule	NOUN
admet-292	201	34	can	can	AUX
admet-292	201	35	get	get	VERB
admet-292	201	36	.	.	PUNCT
admet-292	202	1	there	there	PRON
admet-292	202	2	was	be	VERB
admet-292	202	3	much	much	ADJ
admet-292	202	4	to	to	PART
admet-292	202	5	consider	consider	VERB
admet-292	202	6	.	.	PUNCT
admet-292	203	1	in	in	ADP
admet-292	203	2	several	several	ADJ
admet-292	203	3	instances	instance	NOUN
admet-292	203	4	,	,	PUNCT
admet-292	203	5	it	it	PRON
admet-292	203	6	was	be	AUX
admet-292	203	7	important	important	ADJ
admet-292	203	8	to	to	PART
admet-292	203	9	know	know	VERB
admet-292	203	10	the	the	DET
admet-292	203	11	true	true	ADJ
admet-292	203	12	pka	pka	PROPN
admet-292	203	13	prior	prior	ADV
admet-292	203	14	to	to	ADP
admet-292	203	15	assessment	assessment	NOUN
admet-292	203	16	of	of	ADP
admet-292	203	17	solubilityph	solubilityph	NOUN
admet-292	203	18	.	.	PUNCT
admet-292	204	1	when	when	SCONJ
admet-292	204	2	ionic	ionic	ADJ
admet-292	204	3	strength	strength	NOUN
admet-292	204	4	was	be	AUX
admet-292	204	5	excessive	excessive	ADJ
admet-292	204	6	,	,	PUNCT
admet-292	204	7	or	or	CCONJ
admet-292	204	8	when	when	SCONJ
admet-292	204	9	very	very	ADV
admet-292	204	10	low	low	ADJ
admet-292	204	11	ph	ph	NOUN
admet-292	204	12	was	be	AUX
admet-292	204	13	considered	consider	VERB
admet-292	204	14	,	,	PUNCT
admet-292	204	15	the	the	DET
admet-292	204	16	calibration	calibration	NOUN
admet-292	204	17	of	of	ADP
admet-292	204	18	the	the	DET
admet-292	204	19	ph	ph	ADJ
admet-292	204	20	electrode	electrode	NOUN
admet-292	204	21	required	require	VERB
admet-292	204	22	special	special	ADJ
admet-292	204	23	considerations	consideration	NOUN
admet-292	204	24	.	.	PUNCT
admet-292	205	1	supersaturation	supersaturation	NOUN
admet-292	205	2	had	have	VERB
admet-292	205	3	to	to	PART
admet-292	205	4	be	be	AUX
admet-292	205	5	recognized	recognize	VERB
admet-292	205	6	and	and	CCONJ
admet-292	205	7	accordingly	accordingly	ADV
admet-292	205	8	handled	handle	VERB
admet-292	205	9	.	.	PUNCT
admet-292	206	1	distortions	distortion	NOUN
admet-292	206	2	of	of	ADP
admet-292	206	3	the	the	DET
admet-292	206	4	logs	log	NOUN
admet-292	206	5	-	-	PUNCT
admet-292	206	6	ph	ph	ADJ
admet-292	206	7	curves	curve	NOUN
admet-292	206	8	due	due	ADJ
admet-292	206	9	to	to	ADP
admet-292	206	10	aggregation	aggregation	NOUN
admet-292	206	11	effects	effect	NOUN
admet-292	206	12	had	have	VERB
admet-292	206	13	to	to	PART
admet-292	206	14	be	be	AUX
admet-292	206	15	recognized	recognize	VERB
admet-292	206	16	and	and	CCONJ
admet-292	206	17	appropriately	appropriately	ADV
admet-292	206	18	interpreted	interpret	VERB
admet-292	206	19	.	.	PUNCT
admet-292	207	1	there	there	PRON
admet-292	207	2	were	be	VERB
admet-292	207	3	surprises	surprise	NOUN
admet-292	207	4	regarding	regard	VERB
admet-292	207	5	the	the	DET
admet-292	207	6	ph	ph	ADJ
admet-292	207	7	range	range	NOUN
admet-292	207	8	over	over	ADP
admet-292	207	9	which	which	PRON
admet-292	207	10	co	co	NOUN
admet-292	207	11	-	-	NOUN
admet-292	207	12	precipitates	precipitates	ADJ
admet-292	207	13	(	(	PUNCT
admet-292	207	14	free	free	ADJ
admet-292	207	15	-	-	PUNCT
admet-292	207	16	acid	acid	ADJ
admet-292	207	17	/	/	SYM
admet-292	207	18	base	base	NOUN
admet-292	207	19	drug	drug	NOUN
admet-292	207	20	plus	plus	CCONJ
admet-292	207	21	drug	drug	NOUN
admet-292	207	22	salt	salt	NOUN
admet-292	207	23	)	)	PUNCT
admet-292	207	24	could	could	AUX
admet-292	207	25	form	form	VERB
admet-292	207	26	,	,	PUNCT
admet-292	207	27	parting	part	VERB
admet-292	207	28	from	from	ADP
admet-292	207	29	the	the	DET
admet-292	207	30	single	single	ADJ
admet-292	207	31	-	-	PUNCT
admet-292	207	32	ph	ph	ADJ
admet-292	207	33	significance	significance	NOUN
admet-292	207	34	of	of	ADP
admet-292	207	35	the	the	DET
admet-292	207	36	“	"	PUNCT
admet-292	207	37	phmax	phmax	NOUN
admet-292	207	38	”	"	PUNCT
admet-292	207	39	or	or	CCONJ
admet-292	207	40	“	"	PUNCT
admet-292	207	41	gibbs	gibbs	PROPN
admet-292	207	42	pka	pka	PROPN
admet-292	207	43	”	"	PUNCT
admet-292	207	44	ideas	idea	NOUN
admet-292	207	45	[	[	X
admet-292	207	46	42	42	NUM
admet-292	207	47	,	,	PUNCT
admet-292	207	48	43	43	NUM
admet-292	207	49	]	]	PUNCT
admet-292	207	50	.	.	PUNCT
admet-292	208	1	it	it	PRON
admet-292	208	2	needs	need	VERB
admet-292	208	3	to	to	PART
admet-292	208	4	be	be	AUX
admet-292	208	5	kept	keep	VERB
admet-292	208	6	in	in	ADP
admet-292	208	7	mind	mind	NOUN
admet-292	208	8	that	that	SCONJ
admet-292	208	9	hydrates	hydrate	NOUN
admet-292	208	10	can	can	AUX
admet-292	208	11	form	form	VERB
admet-292	208	12	over	over	ADP
admet-292	208	13	long	long	ADJ
admet-292	208	14	equilibration	equilibration	NOUN
admet-292	208	15	times	time	NOUN
admet-292	208	16	.	.	PUNCT
admet-292	209	1	mass	mass	PROPN
admet-292	209	2	spectrometry	spectrometry	NOUN
admet-292	209	3	could	could	AUX
admet-292	209	4	be	be	AUX
admet-292	209	5	used	use	VERB
admet-292	209	6	to	to	PART
admet-292	209	7	confirm	confirm	VERB
admet-292	209	8	the	the	DET
admet-292	209	9	aggregate	aggregate	NOUN
admet-292	209	10	models	model	NOUN
admet-292	209	11	derived	derive	VERB
admet-292	209	12	from	from	ADP
admet-292	209	13	the	the	DET
admet-292	209	14	computational	computational	ADJ
admet-292	209	15	analysis	analysis	NOUN
admet-292	209	16	of	of	ADP
admet-292	209	17	logs	log	NOUN
admet-292	209	18	-	-	PUNCT
admet-292	209	19	ph	ph	ADJ
admet-292	209	20	data	datum	NOUN
admet-292	209	21	.	.	PUNCT
admet-292	210	1	the	the	DET
admet-292	210	2	identity	identity	NOUN
admet-292	210	3	of	of	ADP
admet-292	210	4	the	the	DET
admet-292	210	5	salt	salt	NOUN
admet-292	210	6	forms	form	NOUN
admet-292	210	7	of	of	ADP
admet-292	210	8	drug	drug	NOUN
admet-292	210	9	precipitates	precipitate	NOUN
admet-292	210	10	might	might	AUX
admet-292	210	11	not	not	PART
admet-292	210	12	be	be	AUX
admet-292	210	13	obvious	obvious	ADJ
admet-292	210	14	unless	unless	SCONJ
admet-292	210	15	the	the	DET
admet-292	210	16	assays	assay	NOUN
admet-292	210	17	were	be	AUX
admet-292	210	18	critically	critically	ADV
admet-292	210	19	designed	design	VERB
admet-292	210	20	.	.	PUNCT
admet-292	211	1	more	more	ADJ
admet-292	211	2	than	than	ADP
admet-292	211	3	one	one	NUM
admet-292	211	4	salt	salt	NOUN
admet-292	211	5	may	may	AUX
admet-292	211	6	form	form	VERB
admet-292	211	7	over	over	ADP
admet-292	211	8	a	a	DET
admet-292	211	9	ph	ph	ADJ
admet-292	211	10	range	range	NOUN
admet-292	211	11	,	,	PUNCT
admet-292	211	12	and	and	CCONJ
admet-292	211	13	sometimes	sometimes	ADV
admet-292	211	14	the	the	DET
admet-292	211	15	salts	salt	NOUN
admet-292	211	16	can	can	AUX
admet-292	211	17	overlap	overlap	VERB
admet-292	211	18	over	over	ADP
admet-292	211	19	a	a	DET
admet-292	211	20	significant	significant	ADJ
admet-292	211	21	range	range	NOUN
admet-292	211	22	of	of	ADP
admet-292	211	23	ph	ph	NOUN
admet-292	211	24	.	.	PUNCT
admet-292	211	25	several	several	ADJ
admet-292	211	26	examples	example	NOUN
admet-292	211	27	of	of	ADP
admet-292	211	28	water	water	NOUN
admet-292	211	29	-	-	PUNCT
admet-292	211	30	soluble	soluble	ADJ
admet-292	211	31	drug	drug	NOUN
admet-292	211	32	-	-	PUNCT
admet-292	211	33	buffer	buffer	NOUN
admet-292	211	34	complexes	complex	NOUN
admet-292	211	35	were	be	AUX
admet-292	211	36	suggested	suggest	VERB
admet-292	211	37	.	.	PUNCT
admet-292	212	1	in	in	ADP
admet-292	212	2	systematic	systematic	ADJ
admet-292	212	3	testing	testing	NOUN
admet-292	212	4	of	of	ADP
admet-292	212	5	salts	salt	NOUN
admet-292	212	6	of	of	ADP
admet-292	212	7	a	a	DET
admet-292	212	8	given	give	VERB
admet-292	212	9	drug	drug	NOUN
admet-292	212	10	,	,	PUNCT
admet-292	212	11	the	the	DET
admet-292	212	12	salt	salt	NOUN
admet-292	212	13	solubility	solubility	NOUN
admet-292	212	14	order	order	NOUN
admet-292	212	15	may	may	AUX
admet-292	212	16	not	not	PART
admet-292	212	17	be	be	AUX
admet-292	212	18	the	the	DET
admet-292	212	19	same	same	ADJ
admet-292	212	20	as	as	ADP
admet-292	212	21	the	the	DET
admet-292	212	22	ksp	ksp	PROPN
admet-292	212	23	order	order	NOUN
admet-292	212	24	.	.	PUNCT
admet-292	213	1	the	the	DET
admet-292	213	2	interpretation	interpretation	NOUN
admet-292	213	3	of	of	ADP
admet-292	213	4	the	the	DET
admet-292	213	5	cmc	cmc	NOUN
admet-292	213	6	is	be	AUX
admet-292	213	7	more	more	ADV
admet-292	213	8	complicated	complicated	ADJ
admet-292	213	9	with	with	ADP
admet-292	213	10	ionizable	ionizable	ADJ
admet-292	213	11	drugs	drug	NOUN
admet-292	213	12	than	than	SCONJ
admet-292	213	13	often	often	ADV
admet-292	213	14	recognized	recognize	VERB
admet-292	213	15	.	.	PUNCT
admet-292	214	1	most	most	ADJ
admet-292	214	2	of	of	ADP
admet-292	214	3	the	the	DET
admet-292	214	4	follow	follow	NOUN
admet-292	214	5	-	-	PUNCT
admet-292	214	6	up	up	ADP
admet-292	214	7	suggestions	suggestion	NOUN
admet-292	214	8	that	that	PRON
admet-292	214	9	can	can	AUX
admet-292	214	10	be	be	AUX
admet-292	214	11	made	make	VERB
admet-292	214	12	to	to	ADP
admet-292	214	13	some	some	PRON
admet-292	214	14	of	of	ADP
admet-292	214	15	the	the	DET
admet-292	214	16	above	above	ADJ
admet-292	214	17	cases	case	NOUN
admet-292	214	18	could	could	AUX
admet-292	214	19	be	be	AUX
admet-292	214	20	to	to	PART
admet-292	214	21	pursue	pursue	VERB
admet-292	214	22	additional	additional	ADJ
admet-292	214	23	corroborative	corroborative	ADJ
admet-292	214	24	investigations	investigation	NOUN
admet-292	214	25	to	to	PART
admet-292	214	26	confirm	confirm	VERB
admet-292	214	27	the	the	DET
admet-292	214	28	presence	presence	NOUN
admet-292	214	29	of	of	ADP
admet-292	214	30	aggregates	aggregate	NOUN
admet-292	214	31	,	,	PUNCT
admet-292	214	32	to	to	PART
admet-292	214	33	identify	identify	VERB
admet-292	214	34	the	the	DET
admet-292	214	35	stoichiometries	stoichiometry	NOUN
admet-292	214	36	of	of	ADP
admet-292	214	37	the	the	DET
admet-292	214	38	solids	solid	NOUN
admet-292	214	39	precipitating	precipitate	VERB
admet-292	214	40	,	,	PUNCT
admet-292	214	41	and	and	CCONJ
admet-292	214	42	the	the	DET
admet-292	214	43	like	like	ADJ
admet-292	214	44	.	.	PUNCT
admet-292	215	1	unusual	unusual	ADJ
admet-292	215	2	stoichiometry	stoichiometry	NOUN
admet-292	215	3	results	result	NOUN
admet-292	215	4	are	be	AUX
admet-292	215	5	seldom	seldom	ADV
admet-292	215	6	confirmed	confirm	VERB
admet-292	215	7	in	in	ADP
admet-292	215	8	a	a	DET
admet-292	215	9	different	different	ADJ
admet-292	215	10	laboratory	laboratory	NOUN
admet-292	215	11	,	,	PUNCT
admet-292	215	12	so	so	CCONJ
admet-292	215	13	reliability	reliability	NOUN
admet-292	215	14	of	of	ADP
admet-292	215	15	the	the	DET
admet-292	215	16	models	model	NOUN
admet-292	215	17	proposed	propose	VERB
admet-292	215	18	can	can	AUX
admet-292	215	19	be	be	AUX
admet-292	215	20	difficult	difficult	ADJ
admet-292	215	21	to	to	PART
admet-292	215	22	assess	assess	VERB
admet-292	215	23	.	.	PUNCT
admet-292	216	1	universally	universally	ADV
admet-292	216	2	,	,	PUNCT
admet-292	216	3	it	it	PRON
admet-292	216	4	seems	seem	VERB
admet-292	216	5	that	that	SCONJ
admet-292	216	6	not	not	PART
admet-292	216	7	enough	enough	ADJ
admet-292	216	8	attention	attention	NOUN
admet-292	216	9	had	have	AUX
admet-292	216	10	been	be	AUX
admet-292	216	11	devoted	devote	VERB
admet-292	216	12	to	to	ADP
admet-292	216	13	the	the	DET
admet-292	216	14	performance	performance	NOUN
admet-292	216	15	of	of	ADP
admet-292	216	16	the	the	DET
admet-292	216	17	ph	ph	ADJ
admet-292	216	18	electrodes	electrode	NOUN
admet-292	216	19	,	,	PUNCT
admet-292	216	20	particularly	particularly	ADV
admet-292	216	21	at	at	ADP
admet-292	216	22	very	very	ADV
admet-292	216	23	low	low	ADJ
admet-292	216	24	ph	ph	ADJ
admet-292	216	25	.	.	PUNCT
admet-292	216	26	a	a	DET
admet-292	216	27	definitive	definitive	ADJ
admet-292	216	28	discussion	discussion	NOUN
admet-292	216	29	of	of	ADP
admet-292	216	30	what	what	PRON
admet-292	216	31	is	be	AUX
admet-292	216	32	meant	mean	VERB
admet-292	216	33	by	by	ADP
admet-292	216	34	“	"	PUNCT
admet-292	216	35	supersaturation	supersaturation	NOUN
admet-292	216	36	”	"	PUNCT
admet-292	216	37	at	at	ADP
admet-292	216	38	the	the	DET
admet-292	216	39	molecular	molecular	ADJ
admet-292	216	40	level	level	NOUN
admet-292	216	41	has	have	AUX
admet-292	216	42	not	not	PART
admet-292	216	43	been	be	AUX
admet-292	216	44	published	publish	VERB
admet-292	216	45	,	,	PUNCT
admet-292	216	46	as	as	ADV
admet-292	216	47	far	far	ADV
admet-292	216	48	as	as	SCONJ
admet-292	216	49	we	we	PRON
admet-292	216	50	are	be	AUX
admet-292	216	51	aware	aware	ADJ
admet-292	216	52	.	.	PUNCT
admet-292	217	1	it	it	PRON
admet-292	217	2	’s	’	VERB
admet-292	217	3	a	a	DET
admet-292	217	4	term	term	NOUN
admet-292	217	5	that	that	PRON
admet-292	217	6	is	be	AUX
admet-292	217	7	used	use	VERB
admet-292	217	8	frequently	frequently	ADV
admet-292	217	9	and	and	CCONJ
admet-292	217	10	has	have	VERB
admet-292	217	11	an	an	DET
admet-292	217	12	intuitive	intuitive	ADJ
admet-292	217	13	appeal	appeal	NOUN
admet-292	217	14	but	but	CCONJ
admet-292	217	15	the	the	DET
admet-292	217	16	exact	exact	ADJ
admet-292	217	17	molecular	molecular	ADJ
admet-292	217	18	mechanism	mechanism	NOUN
admet-292	217	19	has	have	AUX
admet-292	217	20	not	not	PART
admet-292	217	21	been	be	AUX
admet-292	217	22	described	describe	VERB
admet-292	217	23	.	.	PUNCT
admet-292	218	1	do	do	VERB
admet-292	218	2	transient	transient	ADJ
admet-292	218	3	micelles	micelle	NOUN
admet-292	218	4	and/or	and/or	CCONJ
admet-292	218	5	sub	sub	ADJ
admet-292	218	6	-	-	ADJ
admet-292	218	7	micellar	micellar	ADJ
admet-292	218	8	aggregates	aggregate	NOUN
admet-292	218	9	,	,	PUNCT
admet-292	218	10	or	or	CCONJ
admet-292	218	11	drug	drug	NOUN
admet-292	218	12	-	-	PUNCT
admet-292	218	13	excipient	excipient	NOUN
admet-292	218	14	complexes	complex	NOUN
admet-292	218	15	,	,	PUNCT
admet-292	218	16	form	form	NOUN
admet-292	218	17	in	in	ADP
admet-292	218	18	a	a	DET
admet-292	218	19	supersaturated	supersaturated	ADJ
admet-292	218	20	solution	solution	NOUN
admet-292	218	21	?	?	PUNCT
admet-292	219	1	does	do	AUX
admet-292	219	2	meta	meta	ADJ
admet-292	219	3	-	-	PUNCT
admet-292	219	4	stable	stable	ADJ
admet-292	219	5	particle	particle	NOUN
admet-292	219	6	formation	formation	NOUN
admet-292	219	7	,	,	PUNCT
admet-292	219	8	or	or	CCONJ
admet-292	219	9	high	high	ADJ
admet-292	219	10	energy	energy	NOUN
admet-292	219	11	interactions	interaction	NOUN
admet-292	219	12	caused	cause	VERB
admet-292	219	13	by	by	ADP
admet-292	219	14	energetic	energetic	ADJ
admet-292	219	15	phase	phase	NOUN
admet-292	219	16	contacts	contact	NOUN
admet-292	219	17	,	,	PUNCT
admet-292	219	18	or	or	CCONJ
admet-292	219	19	increased	increase	VERB
admet-292	219	20	surface	surface	NOUN
admet-292	219	21	tension	tension	NOUN
admet-292	219	22	lead	lead	NOUN
admet-292	219	23	to	to	ADP
admet-292	219	24	the	the	DET
admet-292	219	25	supersaturation	supersaturation	NOUN
admet-292	219	26	?	?	PUNCT
admet-292	220	1	examples	example	NOUN
admet-292	220	2	of	of	ADP
admet-292	220	3	poorly	poorly	ADV
admet-292	220	4	designed	design	VERB
admet-292	220	5	solubility	solubility	NOUN
admet-292	220	6	assays	assay	NOUN
admet-292	220	7	were	be	AUX
admet-292	220	8	not	not	PART
admet-292	220	9	considered	consider	VERB
admet-292	220	10	as	as	ADP
admet-292	220	11	case	case	NOUN
admet-292	220	12	studies	study	NOUN
admet-292	220	13	.	.	PUNCT
admet-292	221	1	such	such	ADJ
admet-292	221	2	assays	assay	NOUN
admet-292	221	3	outnumber	outnumber	ADJ
admet-292	221	4	alex	alex	PROPN
admet-292	221	5	avdeef	avdeef	PROPN
admet-292	221	6	et	et	PROPN
admet-292	221	7	al	al	PROPN
admet-292	221	8	.	.	PROPN
admet-292	221	9	admet	admet	PROPN
admet-292	221	10	&	&	CCONJ
admet-292	221	11	dmpk	dmpk	PROPN
admet-292	221	12	4(2	4(2	NUM
admet-292	221	13	)	)	PUNCT
admet-292	221	14	(	(	PUNCT
admet-292	221	15	2016	2016	NUM
admet-292	221	16	)	)	PUNCT
admet-292	221	17	117	117	NUM
admet-292	221	18	-	-	SYM
admet-292	221	19	178	178	NUM
admet-292	221	20	128	128	NUM
admet-292	221	21	the	the	DET
admet-292	221	22	well	well	ADV
admet-292	221	23	-	-	PUNCT
admet-292	221	24	designed	design	VERB
admet-292	221	25	measurements	measurement	NOUN
admet-292	221	26	by	by	ADP
admet-292	221	27	a	a	DET
admet-292	221	28	landslide	landslide	NOUN
admet-292	221	29	.	.	PUNCT
admet-292	222	1	the	the	DET
admet-292	222	2	goal	goal	NOUN
admet-292	222	3	of	of	ADP
admet-292	222	4	this	this	DET
admet-292	222	5	commentary	commentary	NOUN
admet-292	222	6	is	be	AUX
admet-292	222	7	to	to	PART
admet-292	222	8	present	present	VERB
admet-292	222	9	specific	specific	ADJ
admet-292	222	10	recommendations	recommendation	NOUN
admet-292	222	11	that	that	PRON
admet-292	222	12	could	could	AUX
admet-292	222	13	elevate	elevate	VERB
admet-292	222	14	the	the	DET
admet-292	222	15	quality	quality	NOUN
admet-292	222	16	of	of	ADP
admet-292	222	17	assay	assay	NOUN
admet-292	222	18	design	design	NOUN
admet-292	222	19	,	,	PUNCT
admet-292	222	20	to	to	PART
admet-292	222	21	lead	lead	VERB
admet-292	222	22	to	to	ADP
admet-292	222	23	improved	improved	ADJ
admet-292	222	24	quality	quality	NOUN
admet-292	222	25	of	of	ADP
admet-292	222	26	measurements	measurement	NOUN
admet-292	222	27	,	,	PUNCT
admet-292	222	28	and	and	CCONJ
admet-292	222	29	impart	impart	VERB
admet-292	222	30	a	a	DET
admet-292	222	31	deeper	deep	ADJ
admet-292	222	32	understanding	understanding	NOUN
admet-292	222	33	of	of	ADP
admet-292	222	34	the	the	DET
admet-292	222	35	underlying	underlying	ADJ
admet-292	222	36	solution	solution	NOUN
admet-292	222	37	chemistry	chemistry	NOUN
admet-292	222	38	in	in	ADP
admet-292	222	39	the	the	DET
admet-292	222	40	presence	presence	NOUN
admet-292	222	41	of	of	ADP
admet-292	222	42	drug	drug	NOUN
admet-292	222	43	precipitates	precipitate	NOUN
admet-292	222	44	,	,	PUNCT
admet-292	222	45	and	and	CCONJ
admet-292	222	46	how	how	SCONJ
admet-292	222	47	such	such	ADJ
admet-292	222	48	solids	solid	NOUN
admet-292	222	49	can	can	AUX
admet-292	222	50	influence	influence	VERB
admet-292	222	51	the	the	DET
admet-292	222	52	interpretation	interpretation	NOUN
admet-292	222	53	of	of	ADP
admet-292	222	54	the	the	DET
admet-292	222	55	solubility	solubility	NOUN
admet-292	222	56	measurement	measurement	NOUN
admet-292	222	57	.	.	PUNCT
admet-292	223	1	methods	method	NOUN
admet-292	223	2	for	for	ADP
admet-292	223	3	measuring	measure	VERB
admet-292	223	4	solubility	solubility	NOUN
admet-292	223	5	“	"	PUNCT
admet-292	223	6	gold	gold	ADJ
admet-292	223	7	standard	standard	NOUN
admet-292	223	8	”	"	PUNCT
admet-292	223	9	shake	shake	NOUN
admet-292	223	10	-	-	PUNCT
admet-292	223	11	flask	flask	NOUN
admet-292	223	12	solubility	solubility	NOUN
admet-292	223	13	method	method	NOUN
admet-292	223	14	the	the	DET
admet-292	223	15	traditional	traditional	ADJ
admet-292	223	16	saturation	saturation	NOUN
admet-292	223	17	shake	shake	NOUN
admet-292	223	18	-	-	PUNCT
admet-292	223	19	flask	flask	NOUN
admet-292	223	20	(	(	PUNCT
admet-292	223	21	sf	sf	NOUN
admet-292	223	22	)	)	PUNCT
admet-292	223	23	method	method	NOUN
admet-292	223	24	is	be	AUX
admet-292	223	25	based	base	VERB
admet-292	223	26	on	on	ADP
admet-292	223	27	simple	simple	ADJ
admet-292	223	28	,	,	PUNCT
admet-292	223	29	easy	easy	NOUN
admet-292	223	30	-	-	PUNCT
admet-292	223	31	to	to	PART
admet-292	223	32	perform	perform	VERB
admet-292	223	33	procedures	procedure	NOUN
admet-292	223	34	,	,	PUNCT
admet-292	223	35	but	but	CCONJ
admet-292	223	36	it	it	PRON
admet-292	223	37	is	be	AUX
admet-292	223	38	time	time	NOUN
admet-292	223	39	-	-	PUNCT
admet-292	223	40	consuming	consume	VERB
admet-292	223	41	and	and	CCONJ
admet-292	223	42	labor	labor	NOUN
admet-292	223	43	intensive	intensive	ADJ
admet-292	223	44	.	.	PUNCT
admet-292	224	1	without	without	ADP
admet-292	224	2	expensive	expensive	ADJ
admet-292	224	3	instrumentation	instrumentation	NOUN
admet-292	224	4	,	,	PUNCT
admet-292	224	5	sf	sf	PROPN
admet-292	224	6	can	can	AUX
admet-292	224	7	be	be	AUX
admet-292	224	8	conducted	conduct	VERB
admet-292	224	9	in	in	ADP
admet-292	224	10	any	any	DET
admet-292	224	11	standard	standard	ADJ
admet-292	224	12	analytical	analytical	ADJ
admet-292	224	13	laboratory	laboratory	NOUN
admet-292	224	14	.	.	PUNCT
admet-292	225	1	but	but	CCONJ
admet-292	225	2	to	to	PART
admet-292	225	3	get	get	VERB
admet-292	225	4	precise	precise	ADJ
admet-292	225	5	and	and	CCONJ
admet-292	225	6	accurate	accurate	ADJ
admet-292	225	7	solubility	solubility	NOUN
admet-292	225	8	results	result	NOUN
admet-292	225	9	,	,	PUNCT
admet-292	225	10	several	several	ADJ
admet-292	225	11	critical	critical	ADJ
admet-292	225	12	experimental	experimental	ADJ
admet-292	225	13	conditions	condition	NOUN
admet-292	225	14	have	have	VERB
admet-292	225	15	to	to	PART
admet-292	225	16	be	be	AUX
admet-292	225	17	considered	consider	VERB
admet-292	225	18	.	.	PUNCT
admet-292	226	1	when	when	SCONJ
admet-292	226	2	the	the	DET
admet-292	226	3	sf	sf	PROPN
admet-292	226	4	method	method	NOUN
admet-292	226	5	is	be	AUX
admet-292	226	6	properly	properly	ADV
admet-292	226	7	performed	perform	VERB
admet-292	226	8	,	,	PUNCT
admet-292	226	9	according	accord	VERB
admet-292	226	10	to	to	ADP
admet-292	226	11	a	a	DET
admet-292	226	12	well	well	ADV
admet-292	226	13	-	-	PUNCT
admet-292	226	14	designed	design	VERB
admet-292	226	15	protocol	protocol	NOUN
admet-292	226	16	,	,	PUNCT
admet-292	226	17	it	it	PRON
admet-292	226	18	provides	provide	VERB
admet-292	226	19	high	high	ADJ
admet-292	226	20	quality	quality	NOUN
admet-292	226	21	data	datum	NOUN
admet-292	226	22	with	with	ADP
admet-292	226	23	standard	standard	ADJ
admet-292	226	24	deviation	deviation	NOUN
admet-292	226	25	lower	low	ADJ
admet-292	226	26	than	than	ADP
admet-292	226	27	±	±	NUM
admet-292	226	28	5	5	NUM
admet-292	226	29	%	%	NOUN
admet-292	226	30	.	.	PUNCT
admet-292	227	1	the	the	DET
admet-292	227	2	sf	sf	PROPN
admet-292	227	3	method	method	NOUN
admet-292	227	4	starts	start	VERB
admet-292	227	5	with	with	ADP
admet-292	227	6	the	the	DET
admet-292	227	7	preparation	preparation	NOUN
admet-292	227	8	of	of	ADP
admet-292	227	9	a	a	DET
admet-292	227	10	sample	sample	NOUN
admet-292	227	11	suspension	suspension	NOUN
admet-292	227	12	,	,	PUNCT
admet-292	227	13	the	the	DET
admet-292	227	14	solution	solution	NOUN
admet-292	227	15	of	of	ADP
admet-292	227	16	the	the	DET
admet-292	227	17	tested	test	VERB
admet-292	227	18	compound	compound	NOUN
admet-292	227	19	in	in	ADP
admet-292	227	20	the	the	DET
admet-292	227	21	selected	select	VERB
admet-292	227	22	solvent	solvent	NOUN
admet-292	227	23	(	(	PUNCT
admet-292	227	24	mainly	mainly	ADV
admet-292	227	25	in	in	ADP
admet-292	227	26	aqueous	aqueous	ADJ
admet-292	227	27	buffer	buffer	NOUN
admet-292	227	28	see	see	VERB
admet-292	227	29	the	the	DET
admet-292	227	30	section	section	NOUN
admet-292	227	31	below	below	ADV
admet-292	227	32	)	)	PUNCT
admet-292	227	33	containing	contain	VERB
admet-292	227	34	a	a	DET
admet-292	227	35	small	small	ADJ
admet-292	227	36	excess	excess	NOUN
admet-292	227	37	of	of	ADP
admet-292	227	38	the	the	DET
admet-292	227	39	solid	solid	NOUN
admet-292	227	40	.	.	PUNCT
admet-292	228	1	(	(	PUNCT
admet-292	228	2	a	a	DET
admet-292	228	3	large	large	ADJ
admet-292	228	4	excess	excess	NOUN
admet-292	228	5	in	in	ADP
admet-292	228	6	the	the	DET
admet-292	228	7	ph	ph	ADJ
admet-292	228	8	region	region	NOUN
admet-292	228	9	where	where	SCONJ
admet-292	228	10	the	the	DET
admet-292	228	11	compound	compound	NOUN
admet-292	228	12	converts	convert	NOUN
admet-292	228	13	from	from	ADP
admet-292	228	14	salt	salt	NOUN
admet-292	228	15	form	form	NOUN
admet-292	228	16	to	to	ADP
admet-292	228	17	a	a	DET
admet-292	228	18	free	free	ADJ
admet-292	228	19	acid	acid	NOUN
admet-292	228	20	/	/	SYM
admet-292	228	21	base	base	NOUN
admet-292	228	22	should	should	AUX
admet-292	228	23	be	be	AUX
admet-292	228	24	avoided	avoid	VERB
admet-292	228	25	,	,	PUNCT
admet-292	228	26	since	since	SCONJ
admet-292	228	27	the	the	DET
admet-292	228	28	disproportionation	disproportionation	NOUN
admet-292	228	29	may	may	AUX
admet-292	228	30	result	result	VERB
admet-292	228	31	in	in	ADP
admet-292	228	32	the	the	DET
admet-292	228	33	free	free	ADJ
admet-292	228	34	acid	acid	NOUN
admet-292	228	35	/	/	SYM
admet-292	228	36	base	base	NOUN
admet-292	228	37	coating	coat	VERB
admet-292	228	38	the	the	DET
admet-292	228	39	surface	surface	NOUN
admet-292	228	40	of	of	ADP
admet-292	228	41	undissolved	undissolve	VERB
admet-292	228	42	drug	drug	NOUN
admet-292	228	43	salt	salt	NOUN
admet-292	228	44	,	,	PUNCT
admet-292	228	45	which	which	PRON
admet-292	228	46	could	could	AUX
admet-292	228	47	result	result	VERB
admet-292	228	48	in	in	ADP
admet-292	228	49	confusing	confusing	ADJ
admet-292	228	50	characterization	characterization	NOUN
admet-292	228	51	of	of	ADP
admet-292	228	52	the	the	DET
admet-292	228	53	isolated	isolated	ADJ
admet-292	228	54	solid	solid	ADJ
admet-292	228	55	state	state	NOUN
admet-292	228	56	material	material	NOUN
admet-292	228	57	.	.	PUNCT
admet-292	228	58	)	)	PUNCT
admet-292	229	1	the	the	DET
admet-292	229	2	volume	volume	NOUN
admet-292	229	3	of	of	ADP
admet-292	229	4	the	the	DET
admet-292	229	5	suspension	suspension	NOUN
admet-292	229	6	that	that	PRON
admet-292	229	7	should	should	AUX
admet-292	229	8	be	be	AUX
admet-292	229	9	used	use	VERB
admet-292	229	10	depends	depend	VERB
admet-292	229	11	on	on	ADP
admet-292	229	12	the	the	DET
admet-292	229	13	solubility	solubility	NOUN
admet-292	229	14	of	of	ADP
admet-292	229	15	the	the	DET
admet-292	229	16	sample	sample	NOUN
admet-292	229	17	and	and	CCONJ
admet-292	229	18	the	the	DET
admet-292	229	19	concentration	concentration	NOUN
admet-292	229	20	detection	detection	NOUN
admet-292	229	21	method	method	NOUN
admet-292	229	22	.	.	PUNCT
admet-292	230	1	for	for	ADP
admet-292	230	2	majority	majority	NOUN
admet-292	230	3	of	of	ADP
admet-292	230	4	compounds	compound	NOUN
admet-292	230	5	,	,	PUNCT
admet-292	230	6	when	when	SCONJ
admet-292	230	7	the	the	DET
admet-292	230	8	saturated	saturate	VERB
admet-292	230	9	solution	solution	NOUN
admet-292	230	10	has	have	VERB
admet-292	230	11	to	to	PART
admet-292	230	12	be	be	AUX
admet-292	230	13	diluted	dilute	VERB
admet-292	230	14	for	for	ADP
admet-292	230	15	assay	assay	NOUN
admet-292	230	16	,	,	PUNCT
admet-292	230	17	1	1	NUM
admet-292	230	18	-	-	SYM
admet-292	230	19	3	3	NUM
admet-292	230	20	mg	mg	NOUN
admet-292	230	21	in	in	ADP
admet-292	230	22	3	3	NUM
admet-292	230	23	ml	ml	NOUN
admet-292	230	24	in	in	ADP
admet-292	230	25	small	small	ADJ
admet-292	230	26	(	(	PUNCT
admet-292	230	27	10	10	NUM
admet-292	230	28	ml	ml	NOUN
admet-292	230	29	)	)	PUNCT
admet-292	230	30	glass	glass	NOUN
admet-292	230	31	vial	vial	NOUN
admet-292	230	32	can	can	AUX
admet-292	230	33	be	be	AUX
admet-292	230	34	optimal	optimal	ADJ
admet-292	230	35	for	for	ADP
admet-292	230	36	precise	precise	ADJ
admet-292	230	37	work	work	NOUN
admet-292	230	38	.	.	PUNCT
admet-292	231	1	in	in	ADP
admet-292	231	2	such	such	ADJ
admet-292	231	3	volume	volume	NOUN
admet-292	231	4	the	the	DET
admet-292	231	5	ph	ph	NOUN
admet-292	231	6	control	control	NOUN
admet-292	231	7	is	be	AUX
admet-292	231	8	easy	easy	ADJ
admet-292	231	9	and	and	CCONJ
admet-292	231	10	one	one	NOUN
admet-292	231	11	can	can	AUX
admet-292	231	12	easily	easily	ADV
admet-292	231	13	follow	follow	VERB
admet-292	231	14	visually	visually	ADV
admet-292	231	15	any	any	DET
admet-292	231	16	changes	change	NOUN
admet-292	231	17	in	in	ADP
admet-292	231	18	the	the	DET
admet-292	231	19	vial	vial	NOUN
admet-292	231	20	during	during	ADP
admet-292	231	21	the	the	DET
admet-292	231	22	equilibration	equilibration	NOUN
admet-292	231	23	.	.	PUNCT
admet-292	232	1	for	for	ADP
admet-292	232	2	extremely	extremely	ADV
admet-292	232	3	insoluble	insoluble	ADJ
admet-292	232	4	compounds	compound	NOUN
admet-292	232	5	,	,	PUNCT
admet-292	232	6	(	(	PUNCT
admet-292	232	7	s	s	X
admet-292	232	8	<	<	X
admet-292	232	9	10	10	NUM
admet-292	232	10	μg	μg	NOUN
admet-292	232	11	/	/	SYM
admet-292	232	12	ml	ml	PROPN
admet-292	232	13	)	)	PUNCT
admet-292	232	14	the	the	DET
admet-292	232	15	concentration	concentration	NOUN
admet-292	232	16	has	have	VERB
admet-292	232	17	to	to	PART
admet-292	232	18	be	be	AUX
admet-292	232	19	measured	measure	VERB
admet-292	232	20	(	(	PUNCT
admet-292	232	21	when	when	SCONJ
admet-292	232	22	using	use	VERB
admet-292	232	23	uv	uv	NOUN
admet-292	232	24	spectrophotometry	spectrophotometry	NOUN
admet-292	232	25	)	)	PUNCT
admet-292	232	26	without	without	ADP
admet-292	232	27	dilution	dilution	NOUN
admet-292	232	28	;	;	PUNCT
admet-292	232	29	thus	thus	ADV
admet-292	232	30	bigger	big	ADJ
admet-292	232	31	volume	volume	NOUN
admet-292	232	32	of	of	ADP
admet-292	232	33	solubility	solubility	NOUN
admet-292	232	34	suspension	suspension	NOUN
admet-292	232	35	(	(	PUNCT
admet-292	232	36	1	1	NUM
admet-292	232	37	mg	mg	NOUN
admet-292	232	38	solid	solid	ADV
admet-292	232	39	in	in	ADP
admet-292	232	40	15	15	NUM
admet-292	232	41	-	-	SYM
admet-292	232	42	20	20	NUM
admet-292	232	43	ml	ml	NOUN
admet-292	232	44	solvent	solvent	NOUN
admet-292	232	45	)	)	PUNCT
admet-292	232	46	is	be	AUX
admet-292	232	47	needed	need	VERB
admet-292	232	48	for	for	ADP
admet-292	232	49	three	three	NUM
admet-292	232	50	replicates	replicate	NOUN
admet-292	232	51	of	of	ADP
admet-292	232	52	sampling	sample	VERB
admet-292	232	53	or	or	CCONJ
admet-292	232	54	when	when	SCONJ
admet-292	232	55	5	5	NUM
admet-292	232	56	cm	cm	NOUN
admet-292	232	57	pathlength	pathlength	NOUN
admet-292	232	58	uv	uv	NOUN
admet-292	232	59	cell	cell	NOUN
admet-292	232	60	has	have	VERB
admet-292	232	61	to	to	PART
admet-292	232	62	be	be	AUX
admet-292	232	63	used	use	VERB
admet-292	232	64	.	.	PUNCT
admet-292	233	1	it	it	PRON
admet-292	233	2	is	be	AUX
admet-292	233	3	a	a	DET
admet-292	233	4	good	good	ADJ
admet-292	233	5	practice	practice	NOUN
admet-292	233	6	to	to	PART
admet-292	233	7	measure	measure	VERB
admet-292	233	8	the	the	DET
admet-292	233	9	ph	ph	NOUN
admet-292	233	10	of	of	ADP
admet-292	233	11	the	the	DET
admet-292	233	12	solubility	solubility	NOUN
admet-292	233	13	suspension	suspension	NOUN
admet-292	233	14	1	1	NUM
admet-292	233	15	h	h	NOUN
admet-292	233	16	after	after	ADP
admet-292	233	17	preparation	preparation	NOUN
admet-292	233	18	and	and	CCONJ
admet-292	233	19	readjust	readjust	VERB
admet-292	233	20	the	the	DET
admet-292	233	21	desired	desire	VERB
admet-292	233	22	ph	ph	NOUN
admet-292	233	23	value	value	NOUN
admet-292	233	24	if	if	SCONJ
admet-292	233	25	it	it	PRON
admet-292	233	26	is	be	AUX
admet-292	233	27	shifted	shift	VERB
admet-292	233	28	which	which	PRON
admet-292	233	29	frequently	frequently	ADV
admet-292	233	30	happens	happen	VERB
admet-292	233	31	when	when	SCONJ
admet-292	233	32	compound	compound	NOUN
admet-292	233	33	is	be	AUX
admet-292	233	34	applied	apply	VERB
admet-292	233	35	in	in	ADP
admet-292	233	36	salt	salt	NOUN
admet-292	233	37	form	form	NOUN
admet-292	233	38	(	(	PUNCT
admet-292	233	39	table	table	NOUN
admet-292	233	40	1	1	NUM
admet-292	233	41	)	)	PUNCT
admet-292	233	42	.	.	PUNCT
admet-292	234	1	the	the	DET
admet-292	234	2	heterogeneous	heterogeneous	ADJ
admet-292	234	3	system	system	NOUN
admet-292	234	4	is	be	AUX
admet-292	234	5	capped	cap	VERB
admet-292	234	6	and	and	CCONJ
admet-292	234	7	vigorously	vigorously	ADV
admet-292	234	8	agitated	agitated	ADJ
admet-292	234	9	(	(	PUNCT
admet-292	234	10	stirred	stir	VERB
admet-292	234	11	)	)	PUNCT
admet-292	234	12	at	at	ADP
admet-292	234	13	a	a	DET
admet-292	234	14	chosen	choose	VERB
admet-292	234	15	temperature	temperature	NOUN
admet-292	234	16	(	(	PUNCT
admet-292	234	17	25	25	NUM
admet-292	234	18	,	,	PUNCT
admet-292	234	19	37	37	NUM
admet-292	234	20	°	°	NOUN
admet-292	234	21	c	c	NOUN
admet-292	234	22	or	or	CCONJ
admet-292	234	23	other	other	ADJ
admet-292	234	24	)	)	PUNCT
admet-292	234	25	in	in	ADP
admet-292	234	26	a	a	DET
admet-292	234	27	thermostated	thermostated	ADJ
admet-292	234	28	bath	bath	NOUN
admet-292	234	29	for	for	ADP
admet-292	234	30	a	a	DET
admet-292	234	31	specified	specify	VERB
admet-292	234	32	time	time	NOUN
admet-292	234	33	(	(	PUNCT
admet-292	234	34	6	6	NUM
admet-292	234	35	,	,	PUNCT
admet-292	234	36	24	24	NUM
admet-292	234	37	,	,	PUNCT
admet-292	234	38	48	48	NUM
admet-292	234	39	h	h	NOUN
admet-292	234	40	or	or	CCONJ
admet-292	234	41	longer	long	ADV
admet-292	234	42	see	see	VERB
admet-292	234	43	the	the	DET
admet-292	234	44	section	section	NOUN
admet-292	234	45	below	below	ADV
admet-292	234	46	)	)	PUNCT
admet-292	234	47	until	until	SCONJ
admet-292	234	48	the	the	DET
admet-292	234	49	solubility	solubility	NOUN
admet-292	234	50	equilibrium	equilibrium	NOUN
admet-292	234	51	has	have	AUX
admet-292	234	52	been	be	AUX
admet-292	234	53	reached	reach	VERB
admet-292	234	54	.	.	PUNCT
admet-292	235	1	after	after	ADP
admet-292	235	2	that	that	PRON
admet-292	235	3	,	,	PUNCT
admet-292	235	4	the	the	DET
admet-292	235	5	solid	solid	NOUN
admet-292	235	6	is	be	AUX
admet-292	235	7	separated	separate	VERB
admet-292	235	8	from	from	ADP
admet-292	235	9	the	the	DET
admet-292	235	10	solution	solution	NOUN
admet-292	235	11	by	by	ADP
admet-292	235	12	sedimentation	sedimentation	NOUN
admet-292	235	13	,	,	PUNCT
admet-292	235	14	centrifugation	centrifugation	NOUN
admet-292	235	15	or	or	CCONJ
admet-292	235	16	filtration	filtration	NOUN
admet-292	235	17	(	(	PUNCT
admet-292	235	18	see	see	VERB
admet-292	235	19	below	below	ADV
admet-292	235	20	)	)	PUNCT
admet-292	235	21	.	.	PUNCT
admet-292	236	1	upon	upon	SCONJ
admet-292	236	2	diluting	dilute	VERB
admet-292	236	3	the	the	DET
admet-292	236	4	sample	sample	NOUN
admet-292	236	5	aliquots	aliquot	NOUN
admet-292	236	6	with	with	ADP
admet-292	236	7	the	the	DET
admet-292	236	8	solvent	solvent	NOUN
admet-292	236	9	,	,	PUNCT
admet-292	236	10	if	if	SCONJ
admet-292	236	11	necessary	necessary	ADJ
admet-292	236	12	,	,	PUNCT
admet-292	236	13	the	the	DET
admet-292	236	14	concentration	concentration	NOUN
admet-292	236	15	of	of	ADP
admet-292	236	16	the	the	DET
admet-292	236	17	saturated	saturate	VERB
admet-292	236	18	solution	solution	NOUN
admet-292	236	19	is	be	AUX
admet-292	236	20	measured	measure	VERB
admet-292	236	21	by	by	ADP
admet-292	236	22	an	an	DET
admet-292	236	23	appropriate	appropriate	ADJ
admet-292	236	24	method	method	NOUN
admet-292	236	25	,	,	PUNCT
admet-292	236	26	most	most	ADV
admet-292	236	27	frequently	frequently	ADV
admet-292	236	28	by	by	ADP
admet-292	236	29	uv	uv	NOUN
admet-292	236	30	-	-	PUNCT
admet-292	236	31	vis	vis	X
admet-292	236	32	or	or	CCONJ
admet-292	236	33	hplc	hplc	NOUN
admet-292	236	34	/	/	SYM
admet-292	236	35	uv	uv	NOUN
admet-292	236	36	-	-	PUNCT
admet-292	236	37	vis	vis	X
admet-292	236	38	.	.	PUNCT
admet-292	237	1	the	the	DET
admet-292	237	2	final	final	ADJ
admet-292	237	3	ph	ph	NOUN
admet-292	237	4	of	of	ADP
admet-292	237	5	the	the	DET
admet-292	237	6	saturated	saturate	VERB
admet-292	237	7	solution	solution	NOUN
admet-292	237	8	is	be	AUX
admet-292	237	9	measured	measure	VERB
admet-292	237	10	.	.	PUNCT
admet-292	238	1	due	due	ADP
admet-292	238	2	to	to	ADP
admet-292	238	3	the	the	DET
admet-292	238	4	lack	lack	NOUN
admet-292	238	5	of	of	ADP
admet-292	238	6	generally	generally	ADV
admet-292	238	7	accepted	accept	VERB
admet-292	238	8	standard	standard	ADJ
admet-292	238	9	way	way	NOUN
admet-292	238	10	to	to	PART
admet-292	238	11	carry	carry	VERB
admet-292	238	12	out	out	ADP
admet-292	238	13	of	of	ADP
admet-292	238	14	this	this	DET
admet-292	238	15	method	method	NOUN
admet-292	238	16	,	,	PUNCT
admet-292	238	17	the	the	DET
admet-292	238	18	published	publish	VERB
admet-292	238	19	solubility	solubility	NOUN
admet-292	238	20	studies	study	NOUN
admet-292	238	21	show	show	VERB
admet-292	238	22	great	great	ADJ
admet-292	238	23	differences	difference	NOUN
admet-292	238	24	in	in	ADP
admet-292	238	25	the	the	DET
admet-292	238	26	experimental	experimental	ADJ
admet-292	238	27	conditions	condition	NOUN
admet-292	238	28	used	use	VERB
admet-292	238	29	[	[	PUNCT
admet-292	238	30	4	4	NUM
admet-292	238	31	]	]	PUNCT
admet-292	238	32	.	.	PUNCT
admet-292	239	1	baka	baka	PROPN
admet-292	239	2	et	et	PROPN
admet-292	239	3	al	al	PROPN
admet-292	239	4	.	.	PUNCT
admet-292	240	1	[	[	X
admet-292	240	2	3	3	X
admet-292	240	3	]	]	PUNCT
admet-292	240	4	suggested	suggest	VERB
admet-292	240	5	a	a	DET
admet-292	240	6	new	new	ADJ
admet-292	240	7	protocol	protocol	NOUN
admet-292	240	8	for	for	ADP
admet-292	240	9	sf	sf	PROPN
admet-292	240	10	method	method	NOUN
admet-292	240	11	using	use	VERB
admet-292	240	12	small	small	ADJ
admet-292	240	13	excess	excess	NOUN
admet-292	240	14	of	of	ADP
admet-292	240	15	solid	solid	ADJ
admet-292	240	16	,	,	PUNCT
admet-292	240	17	6	6	NUM
admet-292	240	18	h	h	NOUN
admet-292	240	19	stirring	stirring	NOUN
admet-292	240	20	and	and	CCONJ
admet-292	240	21	18	18	NUM
admet-292	240	22	h	h	NOUN
admet-292	240	23	sedimentation	sedimentation	NOUN
admet-292	240	24	time	time	NOUN
admet-292	240	25	and	and	CCONJ
admet-292	240	26	running	run	VERB
admet-292	240	27	a	a	DET
admet-292	240	28	minimum	minimum	NOUN
admet-292	240	29	of	of	ADP
admet-292	240	30	3	3	NUM
admet-292	240	31	replicates	replicate	NOUN
admet-292	240	32	.	.	PUNCT
admet-292	241	1	this	this	DET
admet-292	241	2	protocol	protocol	NOUN
admet-292	241	3	was	be	AUX
admet-292	241	4	applied	apply	VERB
admet-292	241	5	for	for	ADP
admet-292	241	6	close	close	ADJ
admet-292	241	7	to	to	PART
admet-292	241	8	100	100	NUM
admet-292	241	9	compounds	compound	NOUN
admet-292	241	10	of	of	ADP
admet-292	241	11	different	different	ADJ
admet-292	241	12	structures	structure	NOUN
admet-292	241	13	,	,	PUNCT
admet-292	241	14	acidbase	acidbase	ADJ
admet-292	241	15	property	property	NOUN
admet-292	241	16	,	,	PUNCT
admet-292	241	17	morphology	morphology	NOUN
admet-292	241	18	,	,	PUNCT
admet-292	241	19	etc	etc	X
admet-292	241	20	.	.	X
admet-292	241	21	,	,	PUNCT
admet-292	241	22	and	and	CCONJ
admet-292	241	23	found	find	VERB
admet-292	241	24	appropriate	appropriate	ADJ
admet-292	241	25	for	for	ADP
admet-292	241	26	the	the	DET
admet-292	241	27	precise	precise	ADJ
admet-292	241	28	measurement	measurement	NOUN
admet-292	241	29	of	of	ADP
admet-292	241	30	equilibrium	equilibrium	NOUN
admet-292	241	31	solubility	solubility	NOUN
admet-292	241	32	[	[	X
admet-292	241	33	63	63	NUM
admet-292	241	34	]	]	PUNCT
admet-292	241	35	.	.	PUNCT
admet-292	242	1	admet	admet	PROPN
admet-292	242	2	&	&	CCONJ
admet-292	242	3	dmpk	dmpk	PROPN
admet-292	242	4	4(2	4(2	NUM
admet-292	242	5	)	)	PUNCT
admet-292	242	6	(	(	PUNCT
admet-292	242	7	2016	2016	NUM
admet-292	242	8	)	)	PUNCT
admet-292	242	9	117	117	NUM
admet-292	242	10	-	-	SYM
admet-292	242	11	178	178	NUM
admet-292	242	12	consensus	consensus	NOUN
admet-292	242	13	recommendations	recommendation	NOUN
admet-292	242	14	for	for	ADP
admet-292	242	15	improving	improve	VERB
admet-292	242	16	solubility	solubility	NOUN
admet-292	242	17	-	-	PUNCT
admet-292	242	18	ph	ph	ADJ
admet-292	242	19	data	datum	NOUN
admet-292	242	20	quality	quality	NOUN
admet-292	242	21	doi	doi	NOUN
admet-292	242	22	:	:	PUNCT
admet-292	242	23	10.5599	10.5599	NUM
admet-292	242	24	/	/	SYM
admet-292	242	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	242	26	129	129	NUM
admet-292	242	27	table	table	NOUN
admet-292	242	28	1	1	NUM
admet-292	242	29	.	.	PUNCT
admet-292	242	30	ph	ph	ADJ
admet-292	242	31	shift	shift	NOUN
admet-292	242	32	of	of	ADP
admet-292	242	33	solubility	solubility	NOUN
admet-292	242	34	suspensions	suspension	NOUN
admet-292	242	35	upon	upon	SCONJ
admet-292	242	36	preparation	preparation	NOUN
admet-292	242	37	sample	sample	NOUN
admet-292	242	38	ph	ph	NOUN
admet-292	242	39	of	of	ADP
admet-292	242	40	br	br	PROPN
admet-292	242	41	buffera	buffera	NOUN
admet-292	242	42	ph	ph	NOUN
admet-292	242	43	of	of	ADP
admet-292	242	44	br	br	NOUN
admet-292	242	45	buffer	buffer	NOUN
admet-292	242	46	after	after	ADP
admet-292	242	47	addition	addition	NOUN
admet-292	242	48	of	of	ADP
admet-292	242	49	solid	solid	ADJ
admet-292	242	50	(	(	PUNCT
admet-292	242	51	t	t	NOUN
admet-292	242	52	=	=	SYM
admet-292	242	53	1	1	NUM
admet-292	242	54	h	h	NOUN
admet-292	242	55	)	)	PUNCT
admet-292	242	56	titrant	titrant	NOUN
admet-292	242	57	added	add	VERB
admet-292	242	58	to	to	PART
admet-292	242	59	readjust	readjust	VERB
admet-292	242	60	the	the	DET
admet-292	242	61	ph	ph	ADJ
admet-292	242	62	final	final	ADJ
admet-292	242	63	ph	ph	NOUN
admet-292	242	64	of	of	ADP
admet-292	242	65	the	the	DET
admet-292	242	66	saturated	saturate	VERB
admet-292	242	67	solution	solution	NOUN
admet-292	242	68	(	(	PUNCT
admet-292	242	69	t	t	NOUN
admet-292	242	70	=	=	SYM
admet-292	242	71	24	24	NUM
admet-292	242	72	h	h	NOUN
admet-292	242	73	)	)	PUNCT
admet-292	242	74	desvenlafaxine	desvenlafaxine	NOUN
admet-292	242	75	fumarate	fumarate	NOUN
admet-292	242	76	9.5	9.5	NUM
admet-292	242	77	5.0	5.0	NUM
admet-292	242	78	naoh	naoh	NOUN
admet-292	242	79	9.5	9.5	NUM
admet-292	242	80	promethazine	promethazine	NOUN
admet-292	242	81	hydrochloride	hydrochloride	NOUN
admet-292	242	82	11.0	11.0	NUM
admet-292	242	83	6.6	6.6	NUM
admet-292	242	84	naoh	naoh	NOUN
admet-292	242	85	10.8	10.8	NUM
admet-292	242	86	quetiapine	quetiapine	NOUN
admet-292	242	87	fumarate	fumarate	NOUN
admet-292	242	88	3.0	3.0	NUM
admet-292	242	89	4.3	4.3	NUM
admet-292	242	90	h3po4	h3po4	NOUN
admet-292	242	91	3.0	3.0	NUM
admet-292	242	92	rosuvastatin	rosuvastatin	NOUN
admet-292	242	93	3.4	3.4	NUM
admet-292	242	94	4.8	4.8	NUM
admet-292	242	95	h3po4	h3po4	NOUN
admet-292	242	96	3.5	3.5	NUM
admet-292	242	97	a	a	DET
admet-292	242	98	br	br	NOUN
admet-292	242	99	=	=	PUNCT
admet-292	242	100	britton	britton	PROPN
admet-292	242	101	-	-	PUNCT
admet-292	242	102	robinson	robinson	PROPN
admet-292	242	103	buffer	buffer	NOUN
admet-292	242	104	(	(	PUNCT
admet-292	242	105	cf	cf	NOUN
admet-292	242	106	.	.	NOUN
admet-292	242	107	,	,	PUNCT
admet-292	242	108	appendix	appendix	VERB
admet-292	242	109	a	a	PRON
admet-292	242	110	)	)	PUNCT
admet-292	242	111	.	.	PUNCT
admet-292	243	1	cheqsol	cheqsol	PROPN
admet-292	243	2	intrinsic	intrinsic	ADJ
admet-292	243	3	solubility	solubility	NOUN
admet-292	243	4	method	method	VERB
admet-292	243	5	an	an	DET
admet-292	243	6	alternative	alternative	NOUN
admet-292	243	7	to	to	ADP
admet-292	243	8	the	the	DET
admet-292	243	9	shake	shake	NOUN
admet-292	243	10	-	-	PUNCT
admet-292	243	11	flask	flask	NOUN
admet-292	243	12	approach	approach	NOUN
admet-292	243	13	for	for	ADP
admet-292	243	14	measuring	measure	VERB
admet-292	243	15	the	the	DET
admet-292	243	16	intrinsic	intrinsic	ADJ
admet-292	243	17	solubility	solubility	NOUN
admet-292	243	18	of	of	ADP
admet-292	243	19	ionizable	ionizable	ADJ
admet-292	243	20	compounds	compound	NOUN
admet-292	243	21	is	be	AUX
admet-292	243	22	the	the	DET
admet-292	243	23	potentiometric	potentiometric	ADJ
admet-292	243	24	acid	acid	NOUN
admet-292	243	25	-	-	PUNCT
admet-292	243	26	base	base	NOUN
admet-292	243	27	titration	titration	NOUN
admet-292	243	28	method	method	NOUN
admet-292	243	29	introduced	introduce	VERB
admet-292	243	30	by	by	ADP
admet-292	243	31	avdeef	avdeef	NOUN
admet-292	243	32	[	[	X
admet-292	243	33	42	42	NUM
admet-292	243	34	]	]	PUNCT
admet-292	243	35	.	.	PUNCT
admet-292	244	1	it	it	PRON
admet-292	244	2	is	be	AUX
admet-292	244	3	not	not	PART
admet-292	244	4	necessary	necessary	ADJ
admet-292	244	5	to	to	PART
admet-292	244	6	separate	separate	VERB
admet-292	244	7	the	the	DET
admet-292	244	8	solid	solid	ADJ
admet-292	244	9	from	from	ADP
admet-292	244	10	the	the	DET
admet-292	244	11	solution	solution	NOUN
admet-292	244	12	in	in	ADP
admet-292	244	13	the	the	DET
admet-292	244	14	potentiometric	potentiometric	ADJ
admet-292	244	15	approach	approach	NOUN
admet-292	244	16	(	(	PUNCT
admet-292	244	17	cf	cf	NOUN
admet-292	244	18	.	.	PUNCT
admet-292	244	19	,	,	PUNCT
admet-292	244	20	separating	separate	VERB
admet-292	244	21	solid	solid	ADV
admet-292	244	22	from	from	ADP
admet-292	244	23	saturated	saturate	VERB
admet-292	244	24	solution	solution	NOUN
admet-292	244	25	)	)	PUNCT
admet-292	244	26	.	.	PUNCT
admet-292	245	1	the	the	DET
admet-292	245	2	intrinsic	intrinsic	ADJ
admet-292	245	3	solubility	solubility	NOUN
admet-292	245	4	is	be	AUX
admet-292	245	5	calculated	calculate	VERB
admet-292	245	6	from	from	ADP
admet-292	245	7	the	the	DET
admet-292	245	8	shift	shift	NOUN
admet-292	245	9	between	between	ADP
admet-292	245	10	the	the	DET
admet-292	245	11	apparent	apparent	ADJ
admet-292	245	12	pka	pka	NOUN
admet-292	245	13	(	(	PUNCT
admet-292	245	14	in	in	ADP
admet-292	245	15	the	the	DET
admet-292	245	16	presence	presence	NOUN
admet-292	245	17	of	of	ADP
admet-292	245	18	precipitate	precipitate	NOUN
admet-292	245	19	)	)	PUNCT
admet-292	245	20	and	and	CCONJ
admet-292	245	21	the	the	DET
admet-292	245	22	true	true	ADJ
admet-292	245	23	aqueous	aqueous	ADJ
admet-292	245	24	pka	pka	NOUN
admet-292	245	25	(	(	PUNCT
admet-292	245	26	in	in	ADP
admet-292	245	27	the	the	DET
admet-292	245	28	absence	absence	NOUN
admet-292	245	29	of	of	ADP
admet-292	245	30	solid	solid	ADJ
admet-292	245	31	)	)	PUNCT
admet-292	245	32	.	.	PUNCT
admet-292	246	1	in	in	ADP
admet-292	246	2	order	order	NOUN
admet-292	246	3	to	to	PART
admet-292	246	4	measure	measure	VERB
admet-292	246	5	the	the	DET
admet-292	246	6	true	true	ADJ
admet-292	246	7	intrinsic	intrinsic	ADJ
admet-292	246	8	solubility	solubility	NOUN
admet-292	246	9	,	,	PUNCT
admet-292	246	10	equilibrium	equilibrium	NOUN
admet-292	246	11	must	must	AUX
admet-292	246	12	be	be	AUX
admet-292	246	13	reached	reach	VERB
admet-292	246	14	.	.	PUNCT
admet-292	247	1	this	this	PRON
admet-292	247	2	can	can	AUX
admet-292	247	3	take	take	VERB
admet-292	247	4	quite	quite	DET
admet-292	247	5	a	a	DET
admet-292	247	6	long	long	ADJ
admet-292	247	7	time	time	NOUN
admet-292	247	8	,	,	PUNCT
admet-292	247	9	especially	especially	ADV
admet-292	247	10	near	near	ADP
admet-292	247	11	the	the	DET
admet-292	247	12	regions	region	NOUN
admet-292	247	13	of	of	ADP
admet-292	247	14	complete	complete	ADJ
admet-292	247	15	dissolution	dissolution	NOUN
admet-292	247	16	.	.	PUNCT
admet-292	248	1	in	in	SCONJ
admet-292	248	2	order	order	NOUN
admet-292	248	3	to	to	PART
admet-292	248	4	ensure	ensure	VERB
admet-292	248	5	equilibrium	equilibrium	NOUN
admet-292	248	6	is	be	AUX
admet-292	248	7	actually	actually	ADV
admet-292	248	8	reached	reach	VERB
admet-292	248	9	and	and	CCONJ
admet-292	248	10	in	in	ADP
admet-292	248	11	a	a	DET
admet-292	248	12	short	short	ADJ
admet-292	248	13	time	time	NOUN
admet-292	248	14	,	,	PUNCT
admet-292	248	15	a	a	DET
admet-292	248	16	method	method	NOUN
admet-292	248	17	called	call	VERB
admet-292	248	18	cheqsol	cheqsol	NOUN
admet-292	248	19	(	(	PUNCT
admet-292	248	20	abbreviation	abbreviation	NOUN
admet-292	248	21	of	of	ADP
admet-292	248	22	“	"	PUNCT
admet-292	248	23	chasing	chase	VERB
admet-292	248	24	equilibrium	equilibrium	NOUN
admet-292	248	25	solubility	solubility	NOUN
admet-292	248	26	”	"	PUNCT
admet-292	248	27	)	)	PUNCT
admet-292	248	28	was	be	AUX
admet-292	248	29	introduced	introduce	VERB
admet-292	248	30	by	by	ADP
admet-292	248	31	stuart	stuart	PROPN
admet-292	248	32	and	and	CCONJ
admet-292	248	33	box	box	PROPN
admet-292	249	1	[	[	X
admet-292	249	2	64	64	NUM
admet-292	249	3	]	]	PUNCT
admet-292	249	4	,	,	PUNCT
admet-292	249	5	and	and	CCONJ
admet-292	249	6	subsequently	subsequently	ADV
admet-292	249	7	developed	develop	VERB
admet-292	249	8	by	by	ADP
admet-292	249	9	sirius	sirius	PROPN
admet-292	249	10	analytical	analytical	PROPN
admet-292	249	11	(	(	PUNCT
admet-292	249	12	uk	uk	PROPN
admet-292	249	13	)	)	PUNCT
admet-292	249	14	.	.	PUNCT
admet-292	250	1	the	the	DET
admet-292	250	2	method	method	NOUN
admet-292	250	3	has	have	AUX
admet-292	250	4	been	be	AUX
admet-292	250	5	validated	validate	VERB
admet-292	250	6	[	[	X
admet-292	250	7	65	65	NUM
admet-292	250	8	]	]	PUNCT
admet-292	250	9	and	and	CCONJ
admet-292	250	10	comparison	comparison	NOUN
admet-292	250	11	of	of	ADP
admet-292	250	12	the	the	DET
admet-292	250	13	intrinsic	intrinsic	ADJ
admet-292	250	14	solubility	solubility	NOUN
admet-292	250	15	results	result	NOUN
admet-292	250	16	measured	measure	VERB
admet-292	250	17	by	by	ADP
admet-292	250	18	the	the	DET
admet-292	250	19	sf	sf	PROPN
admet-292	250	20	and	and	CCONJ
admet-292	250	21	cheqsol	cheqsol	ADJ
admet-292	250	22	techniques	technique	NOUN
admet-292	250	23	,	,	PUNCT
admet-292	250	24	when	when	SCONJ
admet-292	250	25	both	both	PRON
admet-292	250	26	are	be	AUX
admet-292	250	27	properly	properly	ADV
admet-292	250	28	performed	perform	VERB
admet-292	250	29	,	,	PUNCT
admet-292	250	30	shows	show	VERB
admet-292	250	31	good	good	ADJ
admet-292	250	32	agreement	agreement	NOUN
admet-292	250	33	with	with	ADP
admet-292	250	34	a	a	DET
admet-292	250	35	weighted	weight	VERB
admet-292	250	36	linear	linear	ADJ
admet-292	250	37	regression	regression	NOUN
admet-292	250	38	of	of	ADP
admet-292	250	39	logs0	logs0	PROPN
admet-292	251	1	sf	sf	NOUN
admet-292	251	2	=	=	PUNCT
admet-292	252	1	-0.13	-0.13	PUNCT
admet-292	253	1	+	+	NUM
admet-292	253	2	1.00	1.00	NUM
admet-292	253	3	logs0	logs0	NOUN
admet-292	253	4	cheqsol	cheqsol	NOUN
admet-292	253	5	(	(	PUNCT
admet-292	253	6	r2	r2	PROPN
admet-292	253	7	=	=	SYM
admet-292	253	8	0.90	0.90	NUM
admet-292	253	9	,	,	PUNCT
admet-292	253	10	s	s	PART
admet-292	253	11	=	=	NOUN
admet-292	253	12	0.52	0.52	NUM
admet-292	253	13	,	,	PUNCT
admet-292	253	14	n	n	NOUN
admet-292	253	15	=	=	SYM
admet-292	253	16	125	125	NUM
admet-292	253	17	)	)	PUNCT
admet-292	254	1	[	[	X
admet-292	254	2	4	4	NUM
admet-292	254	3	]	]	PUNCT
admet-292	254	4	.	.	PUNCT
admet-292	255	1	the	the	DET
admet-292	255	2	method	method	NOUN
admet-292	255	3	is	be	AUX
admet-292	255	4	based	base	VERB
admet-292	255	5	on	on	ADP
admet-292	255	6	the	the	DET
admet-292	255	7	shift	shift	NOUN
admet-292	255	8	of	of	ADP
admet-292	255	9	the	the	DET
admet-292	255	10	bjerrum	bjerrum	NOUN
admet-292	255	11	’s	’s	PART
admet-292	255	12	plot	plot	NOUN
admet-292	255	13	(	(	PUNCT
admet-292	255	14	cf	cf	NOUN
admet-292	255	15	.	.	PUNCT
admet-292	255	16	,	,	PUNCT
admet-292	255	17	glossary	glossary	NOUN
admet-292	255	18	)	)	PUNCT
admet-292	255	19	for	for	ADP
admet-292	255	20	the	the	DET
admet-292	255	21	titration	titration	NOUN
admet-292	255	22	when	when	SCONJ
admet-292	255	23	precipitate	precipitate	NOUN
admet-292	255	24	is	be	AUX
admet-292	255	25	present	present	ADJ
admet-292	255	26	(	(	PUNCT
admet-292	255	27	figure	figure	NOUN
admet-292	255	28	6	6	NUM
admet-292	255	29	)	)	PUNCT
admet-292	255	30	.	.	PUNCT
admet-292	256	1	the	the	DET
admet-292	256	2	method	method	NOUN
admet-292	256	3	consists	consist	VERB
admet-292	256	4	of	of	ADP
admet-292	256	5	dissolving	dissolve	VERB
admet-292	256	6	the	the	DET
admet-292	256	7	material	material	NOUN
admet-292	256	8	in	in	ADP
admet-292	256	9	water	water	NOUN
admet-292	256	10	and	and	CCONJ
admet-292	256	11	seeking	seek	VERB
admet-292	256	12	precipitation	precipitation	NOUN
admet-292	256	13	by	by	ADP
admet-292	256	14	backtitrating	backtitrate	VERB
admet-292	256	15	the	the	DET
admet-292	256	16	resulting	result	VERB
admet-292	256	17	solution	solution	NOUN
admet-292	256	18	(	(	PUNCT
admet-292	256	19	adding	add	VERB
admet-292	256	20	measured	measured	ADJ
admet-292	256	21	aliquots	aliquot	NOUN
admet-292	256	22	of	of	ADP
admet-292	256	23	base	base	NOUN
admet-292	256	24	or	or	CCONJ
admet-292	256	25	acid	acid	NOUN
admet-292	256	26	titrant	titrant	NOUN
admet-292	256	27	)	)	PUNCT
admet-292	256	28	until	until	SCONJ
admet-292	256	29	first	first	ADJ
admet-292	256	30	precipitation	precipitation	NOUN
admet-292	256	31	is	be	AUX
admet-292	256	32	detected	detect	VERB
admet-292	256	33	.	.	PUNCT
admet-292	257	1	after	after	SCONJ
admet-292	257	2	initial	initial	ADJ
admet-292	257	3	precipitation	precipitation	NOUN
admet-292	257	4	of	of	ADP
admet-292	257	5	the	the	DET
admet-292	257	6	neutral	neutral	ADJ
admet-292	257	7	species	specie	NOUN
admet-292	257	8	has	have	AUX
admet-292	257	9	taken	take	VERB
admet-292	257	10	place	place	NOUN
admet-292	257	11	,	,	PUNCT
admet-292	257	12	the	the	DET
admet-292	257	13	solution	solution	NOUN
admet-292	257	14	is	be	AUX
admet-292	257	15	switched	switch	VERB
admet-292	257	16	from	from	ADP
admet-292	257	17	supersaturated	supersaturated	ADJ
admet-292	257	18	to	to	ADP
admet-292	257	19	subsaturated	subsaturate	VERB
admet-292	257	20	solutions	solution	NOUN
admet-292	257	21	and	and	CCONJ
admet-292	257	22	back	back	ADV
admet-292	257	23	again	again	ADV
admet-292	257	24	several	several	ADJ
admet-292	257	25	times	time	NOUN
admet-292	257	26	,	,	PUNCT
admet-292	257	27	seeking	seek	VERB
admet-292	257	28	an	an	DET
admet-292	257	29	equilibrium	equilibrium	NOUN
admet-292	257	30	ph	ph	NOUN
admet-292	257	31	where	where	SCONJ
admet-292	257	32	the	the	DET
admet-292	257	33	sample	sample	NOUN
admet-292	257	34	is	be	AUX
admet-292	257	35	neither	neither	CCONJ
admet-292	257	36	further	further	ADJ
admet-292	257	37	precipitating	precipitating	NOUN
admet-292	257	38	nor	nor	CCONJ
admet-292	257	39	re	re	VERB
admet-292	257	40	-	-	VERB
admet-292	257	41	dissolving	dissolve	VERB
admet-292	257	42	.	.	PUNCT
admet-292	258	1	the	the	DET
admet-292	258	2	method	method	NOUN
admet-292	258	3	quickly	quickly	ADV
admet-292	258	4	pinpoints	pinpoint	VERB
admet-292	258	5	equilibrium	equilibrium	NOUN
admet-292	258	6	,	,	PUNCT
admet-292	258	7	by	by	ADP
admet-292	258	8	advancing	advance	VERB
admet-292	258	9	the	the	DET
admet-292	258	10	ph	ph	NOUN
admet-292	258	11	further	far	ADV
admet-292	258	12	in	in	ADP
admet-292	258	13	the	the	DET
admet-292	258	14	direction	direction	NOUN
admet-292	258	15	that	that	SCONJ
admet-292	258	16	it	it	PRON
admet-292	258	17	was	be	AUX
admet-292	258	18	already	already	ADV
admet-292	258	19	changing	change	VERB
admet-292	258	20	spontaneously	spontaneously	ADV
admet-292	258	21	.	.	PUNCT
admet-292	259	1	in	in	ADP
admet-292	259	2	contrast	contrast	NOUN
admet-292	259	3	,	,	PUNCT
admet-292	259	4	the	the	DET
admet-292	259	5	dissolution	dissolution	NOUN
admet-292	259	6	titration	titration	NOUN
admet-292	259	7	template	template	NOUN
admet-292	259	8	(	(	PUNCT
admet-292	259	9	dtt	dtt	NOUN
admet-292	259	10	)	)	PUNCT
admet-292	259	11	potentiometric	potentiometric	ADJ
admet-292	259	12	method	method	NOUN
admet-292	259	13	passively	passively	ADV
admet-292	259	14	allows	allow	VERB
admet-292	259	15	equilibration	equilibration	NOUN
admet-292	259	16	to	to	PART
admet-292	259	17	be	be	AUX
admet-292	259	18	reached	reach	VERB
admet-292	259	19	[	[	X
admet-292	259	20	42	42	NUM
admet-292	259	21	]	]	PUNCT
admet-292	259	22	.	.	PUNCT
admet-292	260	1	when	when	SCONJ
admet-292	260	2	precipitation	precipitation	NOUN
admet-292	260	3	is	be	AUX
admet-292	260	4	occurring	occur	VERB
admet-292	260	5	,	,	PUNCT
admet-292	260	6	the	the	DET
admet-292	260	7	ph	ph	NOUN
admet-292	260	8	will	will	AUX
admet-292	260	9	change	change	VERB
admet-292	260	10	in	in	ADP
admet-292	260	11	one	one	NUM
admet-292	260	12	direction	direction	NOUN
admet-292	260	13	;	;	PUNCT
admet-292	260	14	when	when	SCONJ
admet-292	260	15	dissolution	dissolution	NOUN
admet-292	260	16	is	be	AUX
admet-292	260	17	occurring	occur	VERB
admet-292	260	18	,	,	PUNCT
admet-292	260	19	ph	ph	PROPN
admet-292	260	20	will	will	AUX
admet-292	260	21	change	change	VERB
admet-292	260	22	in	in	ADP
admet-292	260	23	the	the	DET
admet-292	260	24	opposite	opposite	ADJ
admet-292	260	25	direction	direction	NOUN
admet-292	260	26	(	(	PUNCT
admet-292	260	27	see	see	VERB
admet-292	260	28	figure	figure	NOUN
admet-292	260	29	7	7	NUM
admet-292	260	30	)	)	PUNCT
admet-292	260	31	.	.	PUNCT
admet-292	261	1	therefore	therefore	ADV
admet-292	261	2	,	,	PUNCT
admet-292	261	3	by	by	ADP
admet-292	261	4	following	follow	VERB
admet-292	261	5	the	the	DET
admet-292	261	6	ph	ph	ADJ
admet-292	261	7	gradient	gradient	NOUN
admet-292	261	8	,	,	PUNCT
admet-292	261	9	the	the	DET
admet-292	261	10	appropriate	appropriate	ADJ
admet-292	261	11	titrant	titrant	NOUN
admet-292	261	12	can	can	AUX
admet-292	261	13	be	be	AUX
admet-292	261	14	added	add	VERB
admet-292	261	15	to	to	PART
admet-292	261	16	accelerate	accelerate	VERB
admet-292	261	17	ph	ph	ADJ
admet-292	261	18	change	change	NOUN
admet-292	261	19	in	in	ADP
admet-292	261	20	the	the	DET
admet-292	261	21	direction	direction	NOUN
admet-292	261	22	of	of	ADP
admet-292	261	23	equilibration	equilibration	NOUN
admet-292	261	24	,	,	PUNCT
admet-292	261	25	above	above	ADP
admet-292	261	26	its	its	PRON
admet-292	261	27	ordinarily	ordinarily	ADV
admet-292	261	28	slow	slow	ADJ
admet-292	261	29	change	change	NOUN
admet-292	261	30	.	.	PUNCT
admet-292	262	1	inevitably	inevitably	ADV
admet-292	262	2	,	,	PUNCT
admet-292	262	3	such	such	ADJ
admet-292	262	4	titrant	titrant	NOUN
admet-292	262	5	additions	addition	NOUN
admet-292	262	6	overshoot	overshoot	VERB
admet-292	262	7	the	the	DET
admet-292	262	8	equilibrium	equilibrium	NOUN
admet-292	262	9	point	point	NOUN
admet-292	262	10	,	,	PUNCT
admet-292	262	11	at	at	ADP
admet-292	262	12	which	which	DET
admet-292	262	13	point	point	NOUN
admet-292	262	14	the	the	DET
admet-292	262	15	gradient	gradient	NOUN
admet-292	262	16	will	will	AUX
admet-292	262	17	be	be	AUX
admet-292	262	18	reversed	reverse	VERB
admet-292	262	19	.	.	PUNCT
admet-292	263	1	a	a	DET
admet-292	263	2	smaller	small	ADJ
admet-292	263	3	amount	amount	NOUN
admet-292	263	4	of	of	ADP
admet-292	263	5	the	the	DET
admet-292	263	6	counter	counter	NOUN
admet-292	263	7	titrant	titrant	NOUN
admet-292	263	8	is	be	AUX
admet-292	263	9	then	then	ADV
admet-292	263	10	added	add	VERB
admet-292	263	11	.	.	PUNCT
admet-292	264	1	a	a	DET
admet-292	264	2	change	change	NOUN
admet-292	264	3	in	in	ADP
admet-292	264	4	ph	ph	NOUN
admet-292	264	5	of	of	ADP
admet-292	264	6	less	less	ADJ
admet-292	264	7	than	than	ADP
admet-292	264	8	0.05	0.05	NUM
admet-292	264	9	is	be	AUX
admet-292	264	10	usually	usually	ADV
admet-292	264	11	sufficient	sufficient	ADJ
admet-292	264	12	to	to	PART
admet-292	264	13	reverse	reverse	VERB
admet-292	264	14	the	the	DET
admet-292	264	15	direction	direction	NOUN
admet-292	264	16	of	of	ADP
admet-292	264	17	the	the	DET
admet-292	264	18	ph	ph	NOUN
admet-292	264	19	-	-	NOUN
admet-292	264	20	gradient	gradient	NOUN
admet-292	264	21	.	.	PUNCT
admet-292	265	1	such	such	ADJ
admet-292	265	2	active	active	ADJ
admet-292	265	3	ph	ph	ADJ
admet-292	265	4	alex	alex	PROPN
admet-292	265	5	avdeef	avdeef	PROPN
admet-292	265	6	et	et	PROPN
admet-292	265	7	al	al	PROPN
admet-292	265	8	.	.	PROPN
admet-292	265	9	admet	admet	PROPN
admet-292	265	10	&	&	CCONJ
admet-292	265	11	dmpk	dmpk	PROPN
admet-292	265	12	4(2	4(2	NUM
admet-292	265	13	)	)	PUNCT
admet-292	265	14	(	(	PUNCT
admet-292	265	15	2016	2016	NUM
admet-292	265	16	)	)	PUNCT
admet-292	265	17	117	117	NUM
admet-292	265	18	-	-	SYM
admet-292	265	19	178	178	NUM
admet-292	265	20	130	130	NUM
admet-292	265	21	nudging	nudging	NOUN
admet-292	265	22	,	,	PUNCT
admet-292	265	23	termed	term	VERB
admet-292	265	24	“	"	PUNCT
admet-292	265	25	chasing	chase	VERB
admet-292	265	26	equilibrium	equilibrium	NOUN
admet-292	265	27	,	,	PUNCT
admet-292	265	28	”	"	PUNCT
admet-292	265	29	is	be	AUX
admet-292	265	30	done	do	VERB
admet-292	265	31	as	as	ADV
admet-292	265	32	many	many	ADJ
admet-292	265	33	times	time	NOUN
admet-292	265	34	as	as	ADP
admet-292	265	35	necessary	necessary	ADJ
admet-292	265	36	.	.	PUNCT
admet-292	266	1	the	the	DET
admet-292	266	2	interpolated	interpolate	VERB
admet-292	266	3	zero	zero	NUM
admet-292	266	4	points	point	NOUN
admet-292	266	5	of	of	ADP
admet-292	266	6	the	the	DET
admet-292	266	7	ph	ph	VERB
admet-292	266	8	-	-	PUNCT
admet-292	266	9	gradient	gradient	NOUN
admet-292	266	10	indicate	indicate	VERB
admet-292	266	11	that	that	SCONJ
admet-292	266	12	the	the	DET
admet-292	266	13	system	system	NOUN
admet-292	266	14	is	be	AUX
admet-292	266	15	at	at	ADP
admet-292	266	16	equilibrium	equilibrium	NOUN
admet-292	266	17	,	,	PUNCT
admet-292	266	18	when	when	SCONJ
admet-292	266	19	neither	neither	CCONJ
admet-292	266	20	precipitation	precipitation	NOUN
admet-292	266	21	nor	nor	CCONJ
admet-292	266	22	dissolution	dissolution	NOUN
admet-292	266	23	is	be	AUX
admet-292	266	24	observed	observe	VERB
admet-292	266	25	.	.	PUNCT
admet-292	267	1	each	each	DET
admet-292	267	2	cycle	cycle	NOUN
admet-292	267	3	between	between	ADP
admet-292	267	4	a	a	DET
admet-292	267	5	supersaturated	supersaturated	ADJ
admet-292	267	6	solution	solution	NOUN
admet-292	267	7	and	and	CCONJ
admet-292	267	8	a	a	DET
admet-292	267	9	subsaturated	subsaturate	VERB
admet-292	267	10	one	one	NUM
admet-292	267	11	will	will	AUX
admet-292	267	12	produce	produce	VERB
admet-292	267	13	a	a	DET
admet-292	267	14	measure	measure	NOUN
admet-292	267	15	of	of	ADP
admet-292	267	16	the	the	DET
admet-292	267	17	figure	figure	NOUN
admet-292	267	18	6	6	NUM
admet-292	267	19	.	.	PUNCT
admet-292	267	20	bjerrum	bjerrum	NOUN
admet-292	267	21	curve	curve	PROPN
admet-292	267	22	(	(	PUNCT
admet-292	267	23	average	average	ADJ
admet-292	267	24	number	number	NOUN
admet-292	267	25	of	of	ADP
admet-292	267	26	associated	associated	ADJ
admet-292	267	27	protons	proton	NOUN
admet-292	267	28	(	(	PUNCT
admet-292	267	29	nh	nh	NOUN
admet-292	267	30	)	)	PUNCT
admet-292	267	31	vs	vs	ADP
admet-292	267	32	ph	ph	NOUN
admet-292	267	33	)	)	PUNCT
admet-292	267	34	for	for	ADP
admet-292	267	35	diclofenac	diclofenac	NOUN
admet-292	267	36	.	.	PUNCT
admet-292	268	1	the	the	DET
admet-292	268	2	experimental	experimental	ADJ
admet-292	268	3	data	data	PROPN
admet-292	268	4	follows	follow	VERB
admet-292	268	5	the	the	DET
admet-292	268	6	theoretical	theoretical	ADJ
admet-292	268	7	curve	curve	NOUN
admet-292	268	8	up	up	ADP
admet-292	268	9	to	to	ADP
admet-292	268	10	the	the	DET
admet-292	268	11	precipitation	precipitation	NOUN
admet-292	268	12	point	point	NOUN
admet-292	268	13	(	(	PUNCT
admet-292	268	14	full	full	ADJ
admet-292	268	15	circle	circle	NOUN
admet-292	268	16	)	)	PUNCT
admet-292	268	17	,	,	PUNCT
admet-292	268	18	when	when	SCONJ
admet-292	268	19	it	it	PRON
admet-292	268	20	jumps	jump	VERB
admet-292	268	21	onto	onto	ADP
admet-292	268	22	the	the	DET
admet-292	268	23	precipitation	precipitation	NOUN
admet-292	268	24	curve	curve	NOUN
admet-292	268	25	.	.	PUNCT
admet-292	269	1	the	the	DET
admet-292	269	2	direction	direction	NOUN
admet-292	269	3	of	of	ADP
admet-292	269	4	titration	titration	NOUN
admet-292	269	5	is	be	AUX
admet-292	269	6	towards	towards	ADP
admet-292	269	7	the	the	DET
admet-292	269	8	acidic	acidic	ADJ
admet-292	269	9	region	region	NOUN
admet-292	269	10	(	(	PUNCT
admet-292	269	11	right	right	ADV
admet-292	269	12	to	to	PART
admet-292	269	13	left	left	VERB
admet-292	269	14	)	)	PUNCT
admet-292	269	15	.	.	PUNCT
admet-292	270	1	intrinsic	intrinsic	ADJ
admet-292	270	2	solubility	solubility	NOUN
admet-292	270	3	(	(	PUNCT
admet-292	270	4	figure	figure	NOUN
admet-292	270	5	7b	7b	NUM
admet-292	270	6	)	)	PUNCT
admet-292	270	7	.	.	PUNCT
admet-292	271	1	usually	usually	ADV
admet-292	271	2	the	the	DET
admet-292	271	3	apparent	apparent	ADJ
admet-292	271	4	intrinsic	intrinsic	ADJ
admet-292	271	5	solubility	solubility	NOUN
admet-292	271	6	values	value	NOUN
admet-292	271	7	are	be	AUX
admet-292	271	8	distributed	distribute	VERB
admet-292	271	9	in	in	ADP
admet-292	271	10	a	a	DET
admet-292	271	11	tight	tight	ADJ
admet-292	271	12	group	group	NOUN
admet-292	271	13	around	around	ADP
admet-292	271	14	the	the	DET
admet-292	271	15	average	average	ADJ
admet-292	271	16	(	(	PUNCT
admet-292	271	17	true	true	ADJ
admet-292	271	18	)	)	PUNCT
admet-292	271	19	value	value	NOUN
admet-292	271	20	.	.	PUNCT
admet-292	272	1	if	if	SCONJ
admet-292	272	2	the	the	DET
admet-292	272	3	intrinsic	intrinsic	ADJ
admet-292	272	4	solubility	solubility	NOUN
admet-292	272	5	values	value	NOUN
admet-292	272	6	are	be	AUX
admet-292	272	7	not	not	PART
admet-292	272	8	randomly	randomly	ADV
admet-292	272	9	distributed	distribute	VERB
admet-292	272	10	(	(	PUNCT
admet-292	272	11	like	like	INTJ
admet-292	272	12	in	in	ADP
admet-292	272	13	figure	figure	NOUN
admet-292	272	14	7a	7a	NUM
admet-292	272	15	)	)	PUNCT
admet-292	272	16	,	,	PUNCT
admet-292	272	17	and	and	CCONJ
admet-292	272	18	show	show	VERB
admet-292	272	19	a	a	DET
admet-292	272	20	systematic	systematic	ADJ
admet-292	272	21	drift	drift	NOUN
admet-292	272	22	in	in	ADP
admet-292	272	23	either	either	DET
admet-292	272	24	direction	direction	NOUN
admet-292	272	25	,	,	PUNCT
admet-292	272	26	then	then	ADV
admet-292	272	27	this	this	PRON
admet-292	272	28	means	mean	VERB
admet-292	272	29	that	that	SCONJ
admet-292	272	30	the	the	DET
admet-292	272	31	equilibrium	equilibrium	NOUN
admet-292	272	32	has	have	AUX
admet-292	272	33	not	not	PART
admet-292	272	34	been	be	AUX
admet-292	272	35	reached	reach	VERB
admet-292	272	36	(	(	PUNCT
admet-292	272	37	or	or	CCONJ
admet-292	272	38	that	that	SCONJ
admet-292	272	39	a	a	DET
admet-292	272	40	more	more	ADV
admet-292	272	41	stable	stable	ADJ
admet-292	272	42	polymorph	polymorph	NOUN
admet-292	272	43	can	can	AUX
admet-292	272	44	be	be	AUX
admet-292	272	45	generated	generate	VERB
admet-292	272	46	)	)	PUNCT
admet-292	272	47	,	,	PUNCT
admet-292	272	48	and	and	CCONJ
admet-292	272	49	the	the	DET
admet-292	272	50	number	number	NOUN
admet-292	272	51	of	of	ADP
admet-292	272	52	cycles	cycle	NOUN
admet-292	272	53	is	be	AUX
admet-292	272	54	increased	increase	VERB
admet-292	272	55	until	until	SCONJ
admet-292	272	56	the	the	DET
admet-292	272	57	equilibrium	equilibrium	NOUN
admet-292	272	58	condition	condition	NOUN
admet-292	272	59	is	be	AUX
admet-292	272	60	achieved	achieve	VERB
admet-292	272	61	.	.	PUNCT
admet-292	273	1	in	in	ADP
admet-292	273	2	the	the	DET
admet-292	273	3	case	case	NOUN
admet-292	273	4	of	of	ADP
admet-292	273	5	shake	shake	NOUN
admet-292	273	6	-	-	PUNCT
admet-292	273	7	flask	flask	NOUN
admet-292	273	8	measurements	measurement	NOUN
admet-292	273	9	the	the	DET
admet-292	273	10	system	system	NOUN
admet-292	273	11	is	be	AUX
admet-292	273	12	allowed	allow	VERB
admet-292	273	13	to	to	PART
admet-292	273	14	shake	shake	VERB
admet-292	273	15	for	for	ADP
admet-292	273	16	6	6	NUM
admet-292	273	17	-	-	SYM
admet-292	273	18	48	48	NUM
admet-292	273	19	h	h	NOUN
admet-292	273	20	followed	follow	VERB
admet-292	273	21	by	by	ADP
admet-292	273	22	long	long	ADJ
admet-292	273	23	sedimentation	sedimentation	PROPN
admet-292	273	24	times	time	NOUN
admet-292	273	25	(	(	PUNCT
admet-292	273	26	cf	cf	NOUN
admet-292	273	27	.	.	NOUN
admet-292	273	28	,	,	PUNCT
admet-292	273	29	“	"	PUNCT
admet-292	273	30	gold	gold	ADJ
admet-292	273	31	standard	standard	NOUN
admet-292	273	32	”	"	PUNCT
admet-292	273	33	shake	shake	NOUN
admet-292	273	34	-	-	PUNCT
admet-292	273	35	flask	flask	NOUN
admet-292	273	36	solubility	solubility	NOUN
admet-292	273	37	method	method	NOUN
admet-292	273	38	)	)	PUNCT
admet-292	273	39	,	,	PUNCT
admet-292	273	40	in	in	ADP
admet-292	273	41	an	an	DET
admet-292	273	42	attempt	attempt	NOUN
admet-292	273	43	to	to	PART
admet-292	273	44	reach	reach	VERB
admet-292	273	45	equilibrium	equilibrium	NOUN
admet-292	273	46	,	,	PUNCT
admet-292	273	47	which	which	PRON
admet-292	273	48	is	be	AUX
admet-292	273	49	then	then	ADV
admet-292	273	50	assumed	assume	VERB
admet-292	273	51	.	.	PUNCT
admet-292	274	1	in	in	ADP
admet-292	274	2	the	the	DET
admet-292	274	3	cheqsol	cheqsol	ADJ
admet-292	274	4	case	case	NOUN
admet-292	274	5	it	it	PRON
admet-292	274	6	is	be	AUX
admet-292	274	7	easy	easy	ADJ
admet-292	274	8	to	to	PART
admet-292	274	9	see	see	VERB
admet-292	274	10	if	if	SCONJ
admet-292	274	11	the	the	DET
admet-292	274	12	equilibrium	equilibrium	NOUN
admet-292	274	13	has	have	AUX
admet-292	274	14	been	be	AUX
admet-292	274	15	reached	reach	VERB
admet-292	274	16	,	,	PUNCT
admet-292	274	17	and	and	CCONJ
admet-292	274	18	it	it	PRON
admet-292	274	19	is	be	AUX
admet-292	274	20	usually	usually	ADV
admet-292	274	21	achieved	achieve	VERB
admet-292	274	22	for	for	ADP
admet-292	274	23	most	most	ADJ
admet-292	274	24	compounds	compound	NOUN
admet-292	274	25	in	in	ADP
admet-292	274	26	1	1	NUM
admet-292	274	27	-	-	SYM
admet-292	274	28	2	2	NUM
admet-292	274	29	h	h	NOUN
admet-292	274	30	(	(	PUNCT
admet-292	274	31	8	8	NUM
admet-292	274	32	cycles	cycle	NOUN
admet-292	274	33	)	)	PUNCT
admet-292	274	34	.	.	PUNCT
admet-292	275	1	although	although	SCONJ
admet-292	275	2	not	not	PART
admet-292	275	3	adapted	adapt	VERB
admet-292	275	4	to	to	PART
admet-292	275	5	use	use	VERB
admet-292	275	6	auxiliary	auxiliary	ADJ
admet-292	275	7	buffers	buffer	NOUN
admet-292	275	8	,	,	PUNCT
admet-292	275	9	the	the	DET
admet-292	275	10	cheqsol	cheqsol	ADJ
admet-292	275	11	technique	technique	NOUN
admet-292	275	12	applies	apply	VERB
admet-292	275	13	mass	mass	NOUN
admet-292	275	14	balance	balance	NOUN
admet-292	275	15	equations	equation	NOUN
admet-292	275	16	to	to	ADP
admet-292	275	17	rigorous	rigorous	ADJ
admet-292	275	18	nonlinear	nonlinear	ADJ
admet-292	275	19	least	least	ADJ
admet-292	275	20	squares	square	NOUN
admet-292	275	21	refinement	refinement	NOUN
admet-292	275	22	of	of	ADP
admet-292	275	23	the	the	DET
admet-292	275	24	model	model	NOUN
admet-292	275	25	based	base	VERB
admet-292	275	26	on	on	ADP
admet-292	275	27	the	the	DET
admet-292	275	28	henderson	henderson	PROPN
admet-292	275	29	-	-	PUNCT
admet-292	275	30	hasselbalch	hasselbalch	PROPN
admet-292	275	31	equation	equation	NOUN
admet-292	275	32	.	.	PUNCT
admet-292	276	1	however	however	ADV
admet-292	276	2	,	,	PUNCT
admet-292	276	3	as	as	SCONJ
admet-292	276	4	described	describe	VERB
admet-292	276	5	previously	previously	ADV
admet-292	276	6	in	in	ADP
admet-292	276	7	this	this	DET
admet-292	276	8	manuscript	manuscript	NOUN
admet-292	276	9	,	,	PUNCT
admet-292	276	10	a	a	DET
admet-292	276	11	very	very	ADV
admet-292	276	12	accurate	accurate	ADJ
admet-292	276	13	determination	determination	NOUN
admet-292	276	14	of	of	ADP
admet-292	276	15	the	the	DET
admet-292	276	16	pka	pka	NOUN
admet-292	276	17	of	of	ADP
admet-292	276	18	the	the	DET
admet-292	276	19	sample	sample	NOUN
admet-292	276	20	is	be	AUX
admet-292	276	21	therefore	therefore	ADV
admet-292	276	22	needed	need	VERB
admet-292	276	23	,	,	PUNCT
admet-292	276	24	because	because	SCONJ
admet-292	276	25	the	the	DET
admet-292	276	26	ionization	ionization	NOUN
admet-292	276	27	constants	constant	NOUN
admet-292	276	28	will	will	AUX
admet-292	276	29	affect	affect	VERB
admet-292	276	30	the	the	DET
admet-292	276	31	accuracy	accuracy	NOUN
admet-292	276	32	of	of	ADP
admet-292	276	33	the	the	DET
admet-292	276	34	concentration	concentration	NOUN
admet-292	276	35	of	of	ADP
admet-292	276	36	the	the	DET
admet-292	276	37	neutral	neutral	ADJ
admet-292	276	38	species	specie	NOUN
admet-292	276	39	,	,	PUNCT
admet-292	276	40	using	use	VERB
admet-292	276	41	the	the	DET
admet-292	276	42	henderson	henderson	PROPN
admet-292	276	43	-	-	PUNCT
admet-292	276	44	hasselbalch	hasselbalch	PROPN
admet-292	276	45	relationship	relationship	NOUN
admet-292	276	46	.	.	PUNCT
admet-292	277	1	therefore	therefore	ADV
admet-292	277	2	a	a	DET
admet-292	277	3	very	very	ADV
admet-292	277	4	accurate	accurate	ADJ
admet-292	277	5	pka	pka	PROPN
admet-292	277	6	needs	need	VERB
admet-292	277	7	to	to	PART
admet-292	277	8	be	be	AUX
admet-292	277	9	measured	measure	VERB
admet-292	277	10	,	,	PUNCT
admet-292	277	11	preferably	preferably	ADV
admet-292	277	12	at	at	ADP
admet-292	277	13	exactly	exactly	ADV
admet-292	277	14	the	the	DET
admet-292	277	15	same	same	ADJ
admet-292	277	16	conditions	condition	NOUN
admet-292	277	17	(	(	PUNCT
admet-292	277	18	temperature	temperature	NOUN
admet-292	277	19	,	,	PUNCT
admet-292	277	20	ionic	ionic	ADJ
admet-292	277	21	strength	strength	NOUN
admet-292	277	22	,	,	PUNCT
admet-292	277	23	...	...	PUNCT
admet-292	277	24	)	)	PUNCT
admet-292	277	25	.	.	PUNCT
admet-292	278	1	it	it	PRON
admet-292	278	2	is	be	AUX
admet-292	278	3	not	not	PART
admet-292	278	4	recommended	recommend	VERB
admet-292	278	5	to	to	PART
admet-292	278	6	use	use	VERB
admet-292	278	7	a	a	DET
admet-292	278	8	“	"	PUNCT
admet-292	278	9	predicted	predict	VERB
admet-292	278	10	”	"	PUNCT
admet-292	278	11	value	value	NOUN
admet-292	278	12	or	or	CCONJ
admet-292	278	13	a	a	DET
admet-292	278	14	pka	pka	NOUN
admet-292	278	15	derived	derive	VERB
admet-292	278	16	from	from	ADP
admet-292	278	17	the	the	DET
admet-292	278	18	logs	log	NOUN
admet-292	278	19	-	-	PUNCT
admet-292	278	20	ph	ph	NOUN
admet-292	278	21	curve	curve	NOUN
admet-292	278	22	(	(	PUNCT
admet-292	278	23	since	since	SCONJ
admet-292	278	24	the	the	DET
admet-292	278	25	henderson	henderson	PROPN
admet-292	278	26	-	-	PUNCT
admet-292	278	27	hasselbalch	hasselbalch	PROPN
admet-292	278	28	equation	equation	NOUN
admet-292	278	29	,	,	PUNCT
admet-292	278	30	in	in	ADP
admet-292	278	31	many	many	ADJ
admet-292	278	32	cases	case	NOUN
admet-292	278	33	,	,	PUNCT
admet-292	278	34	may	may	AUX
admet-292	278	35	not	not	PART
admet-292	278	36	be	be	AUX
admet-292	278	37	valid	valid	ADJ
admet-292	278	38	)	)	PUNCT
admet-292	278	39	.	.	PUNCT
admet-292	279	1	the	the	DET
admet-292	279	2	spread	spread	NOUN
admet-292	279	3	of	of	ADP
admet-292	279	4	the	the	DET
admet-292	279	5	crossing	crossing	NOUN
admet-292	279	6	points	point	NOUN
admet-292	279	7	in	in	ADP
admet-292	279	8	cheqsol	cheqsol	NOUN
admet-292	279	9	is	be	AUX
admet-292	279	10	used	use	VERB
admet-292	279	11	to	to	PART
admet-292	279	12	determine	determine	VERB
admet-292	279	13	the	the	DET
admet-292	279	14	coefficient	coefficient	NOUN
admet-292	279	15	of	of	ADP
admet-292	279	16	variation	variation	NOUN
admet-292	279	17	(	(	PUNCT
admet-292	279	18	cv	cv	NOUN
admet-292	279	19	)	)	PUNCT
admet-292	279	20	of	of	ADP
admet-292	279	21	the	the	DET
admet-292	279	22	mean	mean	ADJ
admet-292	279	23	intrinsic	intrinsic	ADJ
admet-292	279	24	solubility	solubility	NOUN
admet-292	279	25	result	result	NOUN
admet-292	279	26	,	,	PUNCT
admet-292	279	27	which	which	PRON
admet-292	279	28	is	be	AUX
admet-292	279	29	usually	usually	ADV
admet-292	279	30	<	<	X
admet-292	279	31	4	4	NUM
admet-292	279	32	%	%	NOUN
admet-292	279	33	.	.	PUNCT
admet-292	280	1	the	the	DET
admet-292	280	2	final	final	ADJ
admet-292	280	3	intrinsic	intrinsic	ADJ
admet-292	280	4	solubility	solubility	NOUN
admet-292	280	5	value	value	NOUN
admet-292	280	6	is	be	AUX
admet-292	280	7	calculated	calculate	VERB
admet-292	280	8	from	from	ADP
admet-292	280	9	an	an	DET
admet-292	280	10	average	average	NOUN
admet-292	280	11	of	of	ADP
admet-292	280	12	several	several	ADJ
admet-292	280	13	separate	separate	ADJ
admet-292	280	14	experiments	experiment	NOUN
admet-292	280	15	with	with	ADP
admet-292	280	16	8	8	ADJ
admet-292	280	17	cycles	cycle	NOUN
admet-292	280	18	per	per	ADP
admet-292	280	19	experiment	experiment	NOUN
admet-292	280	20	,	,	PUNCT
admet-292	280	21	adequate	adequate	ADJ
admet-292	280	22	to	to	PART
admet-292	280	23	provide	provide	VERB
admet-292	280	24	the	the	DET
admet-292	280	25	intrinsic	intrinsic	ADJ
admet-292	280	26	solubility	solubility	NOUN
admet-292	280	27	value	value	NOUN
admet-292	280	28	with	with	ADP
admet-292	280	29	an	an	DET
admet-292	280	30	associated	associated	ADJ
admet-292	280	31	statistical	statistical	ADJ
admet-292	280	32	reproducibility	reproducibility	NOUN
admet-292	280	33	error	error	NOUN
admet-292	280	34	(	(	PUNCT
admet-292	280	35	±sd	±sd	NOUN
admet-292	280	36	)	)	PUNCT
admet-292	281	1	[	[	X
admet-292	281	2	1	1	NUM
admet-292	281	3	]	]	PUNCT
admet-292	281	4	.	.	PUNCT
admet-292	282	1	admet	admet	PROPN
admet-292	282	2	&	&	CCONJ
admet-292	282	3	dmpk	dmpk	PROPN
admet-292	282	4	4(2	4(2	NUM
admet-292	282	5	)	)	PUNCT
admet-292	282	6	(	(	PUNCT
admet-292	282	7	2016	2016	NUM
admet-292	282	8	)	)	PUNCT
admet-292	282	9	117	117	NUM
admet-292	282	10	-	-	SYM
admet-292	282	11	178	178	NUM
admet-292	282	12	consensus	consensus	NOUN
admet-292	282	13	recommendations	recommendation	NOUN
admet-292	282	14	for	for	ADP
admet-292	282	15	improving	improve	VERB
admet-292	282	16	solubility	solubility	NOUN
admet-292	282	17	-	-	PUNCT
admet-292	282	18	ph	ph	ADJ
admet-292	282	19	data	datum	NOUN
admet-292	282	20	quality	quality	NOUN
admet-292	282	21	doi	doi	NOUN
admet-292	282	22	:	:	PUNCT
admet-292	282	23	10.5599	10.5599	NUM
admet-292	282	24	/	/	SYM
admet-292	282	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	282	26	131	131	NUM
admet-292	282	27	figure	figure	NOUN
admet-292	282	28	7	7	NUM
admet-292	282	29	.	.	PUNCT
admet-292	282	30	chasing	chase	VERB
admet-292	282	31	equilibrium	equilibrium	NOUN
admet-292	282	32	of	of	ADP
admet-292	282	33	diclofenac	diclofenac	NOUN
admet-292	282	34	(	(	PUNCT
admet-292	282	35	1	1	NUM
admet-292	282	36	of	of	ADP
admet-292	282	37	10	10	NUM
admet-292	282	38	runs	run	NOUN
admet-292	282	39	):	):	PUNCT
admet-292	282	40	the	the	DET
admet-292	282	41	ph	ph	NOUN
admet-292	282	42	gradient	gradient	NOUN
admet-292	282	43	(	(	PUNCT
admet-292	282	44	dph	dph	PROPN
admet-292	282	45	/	/	SYM
admet-292	282	46	dt	dt	NOUN
admet-292	282	47	)	)	PUNCT
admet-292	282	48	changes	change	NOUN
admet-292	282	49	from	from	ADP
admet-292	282	50	a	a	DET
admet-292	282	51	positive	positive	ADJ
admet-292	282	52	value	value	NOUN
admet-292	282	53	(	(	PUNCT
admet-292	282	54	neutral	neutral	ADJ
admet-292	282	55	form	form	NOUN
admet-292	282	56	is	be	AUX
admet-292	282	57	precipitating	precipitate	VERB
admet-292	282	58	)	)	PUNCT
admet-292	282	59	in	in	ADP
admet-292	282	60	the	the	DET
admet-292	282	61	supersaturated	supersaturated	ADJ
admet-292	282	62	region	region	NOUN
admet-292	282	63	to	to	ADP
admet-292	282	64	a	a	DET
admet-292	282	65	negative	negative	ADJ
admet-292	282	66	one	one	NOUN
admet-292	282	67	(	(	PUNCT
admet-292	282	68	neutral	neutral	ADJ
admet-292	282	69	form	form	NOUN
admet-292	282	70	is	be	AUX
admet-292	282	71	re	re	VERB
admet-292	282	72	-	-	VERB
admet-292	282	73	dissolving	dissolve	VERB
admet-292	282	74	)	)	PUNCT
admet-292	282	75	in	in	ADP
admet-292	282	76	the	the	DET
admet-292	282	77	subsaturated	subsaturated	ADJ
admet-292	282	78	one	one	NUM
admet-292	282	79	:	:	PUNCT
admet-292	282	80	the	the	DET
admet-292	282	81	rate	rate	NOUN
admet-292	282	82	of	of	ADP
admet-292	282	83	ph	ph	ADJ
admet-292	282	84	change	change	NOUN
admet-292	282	85	is	be	AUX
admet-292	282	86	zero	zero	NUM
admet-292	282	87	at	at	ADP
admet-292	282	88	the	the	DET
admet-292	282	89	crossing	crossing	NOUN
admet-292	282	90	points	point	NOUN
admet-292	282	91	(	(	PUNCT
admet-292	282	92	○	○	PROPN
admet-292	282	93	)	)	PUNCT
admet-292	282	94	.	.	PUNCT
admet-292	283	1	in	in	ADP
admet-292	283	2	this	this	DET
admet-292	283	3	run	run	NOUN
admet-292	283	4	eight	eight	NUM
admet-292	283	5	cycles	cycle	NOUN
admet-292	283	6	were	be	AUX
admet-292	283	7	performed	perform	VERB
admet-292	283	8	(	(	PUNCT
admet-292	283	9	8	8	NUM
admet-292	283	10	crossing	crossing	NOUN
admet-292	283	11	points	point	NOUN
admet-292	283	12	)	)	PUNCT
admet-292	283	13	.	.	PUNCT
admet-292	284	1	each	each	DET
admet-292	284	2	crossing	crossing	NOUN
admet-292	284	3	point	point	NOUN
admet-292	284	4	in	in	ADP
admet-292	284	5	plot	plot	NOUN
admet-292	284	6	a	a	PRON
admet-292	284	7	)	)	PUNCT
admet-292	284	8	corresponds	correspond	VERB
admet-292	284	9	to	to	ADP
admet-292	284	10	an	an	DET
admet-292	284	11	intrinsic	intrinsic	ADJ
admet-292	284	12	solubility	solubility	NOUN
admet-292	284	13	value	value	NOUN
admet-292	284	14	in	in	ADP
admet-292	284	15	b	b	NOUN
admet-292	284	16	)	)	PUNCT
admet-292	284	17	.	.	PUNCT
admet-292	285	1	that	that	PRON
admet-292	285	2	is	be	AUX
admet-292	285	3	,	,	PUNCT
admet-292	285	4	the	the	DET
admet-292	285	5	first	first	ADJ
admet-292	285	6	crossing	crossing	NOUN
admet-292	285	7	point	point	NOUN
admet-292	285	8	,	,	PUNCT
admet-292	285	9	point	point	NOUN
admet-292	285	10	1	1	NUM
admet-292	285	11	in	in	ADP
admet-292	285	12	plot	plot	NOUN
admet-292	285	13	a	a	PRON
admet-292	285	14	)	)	PUNCT
admet-292	285	15	occurs	occur	VERB
admet-292	285	16	at	at	ADP
admet-292	285	17	around	around	ADV
admet-292	285	18	20	20	NUM
admet-292	285	19	min	min	NOUN
admet-292	285	20	after	after	SCONJ
admet-292	285	21	the	the	DET
admet-292	285	22	experiment	experiment	NOUN
admet-292	285	23	has	have	AUX
admet-292	285	24	started	start	VERB
admet-292	285	25	,	,	PUNCT
admet-292	285	26	giving	give	VERB
admet-292	285	27	an	an	DET
admet-292	285	28	intrinsic	intrinsic	ADJ
admet-292	285	29	solubility	solubility	NOUN
admet-292	285	30	value	value	NOUN
admet-292	285	31	(	(	PUNCT
admet-292	285	32	first	first	ADJ
admet-292	285	33	crossing	crossing	NOUN
admet-292	285	34	point	point	NOUN
admet-292	285	35	)	)	PUNCT
admet-292	285	36	of	of	ADP
admet-292	285	37	1.06	1.06	NUM
admet-292	285	38	μg	μg	NOUN
admet-292	285	39	/	/	SYM
admet-292	285	40	ml	ml	PROPN
admet-292	285	41	(	(	PUNCT
admet-292	285	42	plot	plot	NOUN
admet-292	285	43	b	b	NOUN
admet-292	285	44	)	)	PUNCT
admet-292	285	45	;	;	PUNCT
admet-292	285	46	point	point	NOUN
admet-292	285	47	2	2	NUM
admet-292	285	48	,	,	PUNCT
admet-292	285	49	22	22	NUM
admet-292	285	50	min	min	NOUN
admet-292	285	51	and	and	CCONJ
admet-292	285	52	1.07	1.07	NUM
admet-292	285	53	μg	μg	NOUN
admet-292	285	54	/	/	SYM
admet-292	285	55	ml	ml	PROPN
admet-292	285	56	;	;	PUNCT
admet-292	285	57	point	point	NOUN
admet-292	285	58	3	3	NUM
admet-292	285	59	,	,	PUNCT
admet-292	285	60	26	26	NUM
admet-292	285	61	min	min	NOUN
admet-292	285	62	,	,	PUNCT
admet-292	285	63	1.08	1.08	NUM
admet-292	285	64	μg	μg	NOUN
admet-292	285	65	/	/	SYM
admet-292	285	66	ml	ml	PROPN
admet-292	285	67	;	;	PUNCT
admet-292	285	68	point	point	NOUN
admet-292	285	69	4	4	NUM
admet-292	285	70	,	,	PUNCT
admet-292	285	71	28	28	NUM
admet-292	285	72	min	min	NOUN
admet-292	285	73	,	,	PUNCT
admet-292	285	74	1.07	1.07	NUM
admet-292	285	75	μg	μg	NOUN
admet-292	285	76	/	/	SYM
admet-292	285	77	ml	ml	PROPN
admet-292	285	78	;	;	PUNCT
admet-292	285	79	point	point	NOUN
admet-292	285	80	5	5	NUM
admet-292	285	81	,	,	PUNCT
admet-292	285	82	32	32	NUM
admet-292	285	83	min	min	NOUN
admet-292	285	84	,	,	PUNCT
admet-292	285	85	1.06	1.06	NUM
admet-292	285	86	μg	μg	PROPN
admet-292	285	87	/	/	SYM
admet-292	285	88	ml	ml	PROPN
admet-292	285	89	;	;	PUNCT
admet-292	285	90	point	point	NOUN
admet-292	285	91	6	6	NUM
admet-292	285	92	,	,	PUNCT
admet-292	285	93	35	35	NUM
admet-292	285	94	min	min	NOUN
admet-292	285	95	,	,	PUNCT
admet-292	285	96	1.07	1.07	NUM
admet-292	285	97	μg	μg	NOUN
admet-292	285	98	/	/	SYM
admet-292	285	99	ml	ml	PROPN
admet-292	285	100	;	;	PUNCT
admet-292	285	101	point	point	NOUN
admet-292	285	102	7	7	NUM
admet-292	285	103	,	,	PUNCT
admet-292	285	104	37	37	NUM
admet-292	285	105	min	min	NOUN
admet-292	285	106	,	,	PUNCT
admet-292	285	107	1.06	1.06	NUM
admet-292	285	108	μg	μg	PROPN
admet-292	285	109	/	/	SYM
admet-292	285	110	ml	ml	PROPN
admet-292	285	111	and	and	CCONJ
admet-292	285	112	point	point	VERB
admet-292	285	113	8	8	NUM
admet-292	285	114	,	,	PUNCT
admet-292	285	115	40	40	NUM
admet-292	285	116	min	min	NOUN
admet-292	285	117	,	,	PUNCT
admet-292	285	118	1.04	1.04	NUM
admet-292	285	119	μg	μg	NOUN
admet-292	285	120	/	/	SYM
admet-292	285	121	ml	ml	NOUN
admet-292	285	122	.	.	PUNCT
admet-292	286	1	full	full	ADJ
admet-292	286	2	triangles	triangle	NOUN
admet-292	286	3	(	(	PUNCT
admet-292	286	4	▲	▲	PUNCT
admet-292	286	5	)	)	PUNCT
admet-292	286	6	represent	represent	VERB
admet-292	286	7	when	when	SCONJ
admet-292	286	8	acid	acid	NOUN
admet-292	286	9	titrant	titrant	NOUN
admet-292	286	10	is	be	AUX
admet-292	286	11	added	add	VERB
admet-292	286	12	;	;	PUNCT
admet-292	286	13	squares	square	NOUN
admet-292	286	14	(	(	PUNCT
admet-292	286	15	■	■	NOUN
admet-292	286	16	)	)	PUNCT
admet-292	286	17	when	when	SCONJ
admet-292	286	18	base	base	NOUN
admet-292	286	19	titrant	titrant	NOUN
admet-292	286	20	is	be	AUX
admet-292	286	21	added	add	VERB
admet-292	286	22	,	,	PUNCT
admet-292	286	23	(	(	PUNCT
admet-292	286	24	◊	◊	NOUN
admet-292	286	25	)	)	PUNCT
admet-292	286	26	mean	mean	VERB
admet-292	286	27	no	no	DET
admet-292	286	28	titrant	titrant	NOUN
admet-292	286	29	added	add	VERB
admet-292	286	30	;	;	PUNCT
admet-292	286	31	(	(	PUNCT
admet-292	286	32	○	○	X
admet-292	286	33	)	)	PUNCT
admet-292	286	34	are	be	AUX
admet-292	286	35	the	the	DET
admet-292	286	36	crossing	crossing	NOUN
admet-292	286	37	points	point	NOUN
admet-292	286	38	,	,	PUNCT
admet-292	286	39	when	when	SCONJ
admet-292	286	40	the	the	DET
admet-292	286	41	ph	ph	NOUN
admet-292	286	42	does	do	AUX
admet-292	286	43	not	not	PART
admet-292	286	44	change	change	VERB
admet-292	286	45	,	,	PUNCT
admet-292	286	46	and	and	CCONJ
admet-292	286	47	the	the	DET
admet-292	286	48	large	large	ADJ
admet-292	286	49	empty	empty	ADJ
admet-292	286	50	triangle	triangle	NOUN
admet-292	286	51	is	be	AUX
admet-292	286	52	where	where	SCONJ
admet-292	286	53	the	the	DET
admet-292	286	54	experiment	experiment	NOUN
admet-292	286	55	starts	start	VERB
admet-292	286	56	.	.	PUNCT
admet-292	287	1	the	the	DET
admet-292	287	2	measurements	measurement	NOUN
admet-292	287	3	are	be	AUX
admet-292	287	4	performed	perform	VERB
admet-292	287	5	under	under	ADP
admet-292	287	6	inert	inert	ADJ
admet-292	287	7	gas	gas	NOUN
admet-292	287	8	(	(	PUNCT
admet-292	287	9	argon	argon	NOUN
admet-292	287	10	or	or	CCONJ
admet-292	287	11	nitrogen	nitrogen	NOUN
admet-292	287	12	)	)	PUNCT
admet-292	287	13	and	and	CCONJ
admet-292	287	14	degassed	degassed	ADJ
admet-292	287	15	reagents	reagent	NOUN
admet-292	287	16	and	and	CCONJ
admet-292	287	17	water	water	NOUN
admet-292	287	18	are	be	AUX
admet-292	287	19	used	use	VERB
admet-292	287	20	(	(	PUNCT
admet-292	287	21	minimal	minimal	ADJ
admet-292	287	22	dissolved	dissolve	VERB
admet-292	287	23	co2	co2	NOUN
admet-292	287	24	)	)	PUNCT
admet-292	287	25	.	.	PUNCT
admet-292	288	1	the	the	DET
admet-292	288	2	total	total	ADJ
admet-292	288	3	ionic	ionic	ADJ
admet-292	288	4	strength	strength	NOUN
admet-292	288	5	,	,	PUNCT
admet-292	288	6	i	i	PRON
admet-292	288	7	,	,	PUNCT
admet-292	288	8	is	be	AUX
admet-292	288	9	kept	keep	VERB
admet-292	288	10	nearly	nearly	ADV
admet-292	288	11	constant	constant	ADJ
admet-292	288	12	at	at	ADP
admet-292	288	13	0.15	0.15	NUM
admet-292	288	14	m	m	NOUN
admet-292	288	15	kcl	kcl	NOUN
admet-292	288	16	and	and	CCONJ
admet-292	288	17	the	the	DET
admet-292	288	18	temperature	temperature	NOUN
admet-292	288	19	is	be	AUX
admet-292	288	20	precisely	precisely	ADV
admet-292	288	21	controlled	control	VERB
admet-292	288	22	throughout	throughout	ADP
admet-292	288	23	(	(	PUNCT
admet-292	288	24	e.g.	e.g.	ADV
admet-292	288	25	,	,	PUNCT
admet-292	288	26	25.0	25.0	NUM
admet-292	288	27	±	±	NUM
admet-292	288	28	0.1	0.1	NUM
admet-292	288	29	oc	oc	PROPN
admet-292	288	30	)	)	PUNCT
admet-292	288	31	.	.	PUNCT
admet-292	289	1	the	the	DET
admet-292	289	2	ph	ph	ADJ
admet-292	289	3	electrode	electrode	NOUN
admet-292	289	4	is	be	AUX
admet-292	289	5	calibrated	calibrate	VERB
admet-292	289	6	using	use	VERB
admet-292	289	7	the	the	DET
admet-292	289	8	“	"	PUNCT
admet-292	289	9	four	four	NUM
admet-292	289	10	-	-	PUNCT
admet-292	289	11	plus	plus	NOUN
admet-292	289	12	”	"	PUNCT
admet-292	289	13	method	method	NOUN
admet-292	289	14	(	(	PUNCT
admet-292	289	15	cf	cf	NOUN
admet-292	289	16	.	.	NOUN
admet-292	289	17	,	,	PUNCT
admet-292	289	18	appendix	appendix	VERB
admet-292	289	19	c	c	NOUN
admet-292	289	20	)	)	PUNCT
admet-292	289	21	.	.	PUNCT
admet-292	290	1	diclofenac	diclofenac	NOUN
admet-292	290	2	is	be	AUX
admet-292	290	3	shown	show	VERB
admet-292	290	4	below	below	ADP
admet-292	290	5	as	as	ADP
admet-292	290	6	an	an	DET
admet-292	290	7	example	example	NOUN
admet-292	290	8	[	[	X
admet-292	290	9	66	66	NUM
admet-292	290	10	]	]	PUNCT
admet-292	290	11	.	.	PUNCT
admet-292	291	1	figure	figure	NOUN
admet-292	291	2	6	6	NUM
admet-292	291	3	shows	show	VERB
admet-292	291	4	the	the	DET
admet-292	291	5	bjerrum	bjerrum	NOUN
admet-292	291	6	curve	curve	NOUN
admet-292	291	7	for	for	ADP
admet-292	291	8	diclofenac	diclofenac	NOUN
admet-292	291	9	.	.	PUNCT
admet-292	292	1	for	for	ADP
admet-292	292	2	fully	fully	ADV
admet-292	292	3	dissolved	dissolve	VERB
admet-292	292	4	diclofenac	diclofenac	NOUN
admet-292	292	5	the	the	DET
admet-292	292	6	titration	titration	NOUN
admet-292	292	7	curve	curve	NOUN
admet-292	292	8	is	be	AUX
admet-292	292	9	calculated	calculate	VERB
admet-292	292	10	from	from	ADP
admet-292	292	11	the	the	DET
admet-292	292	12	pka	pka	NOUN
admet-292	292	13	of	of	ADP
admet-292	292	14	diclofenac	diclofenac	NOUN
admet-292	292	15	(	(	PUNCT
admet-292	292	16	measured	measure	VERB
admet-292	292	17	previously	previously	ADV
admet-292	292	18	at	at	ADP
admet-292	292	19	the	the	DET
admet-292	292	20	same	same	ADJ
admet-292	292	21	conditions	condition	NOUN
admet-292	292	22	as	as	ADP
admet-292	292	23	the	the	DET
admet-292	292	24	solubility	solubility	NOUN
admet-292	292	25	experiments	experiment	NOUN
admet-292	292	26	)	)	PUNCT
admet-292	292	27	and	and	CCONJ
admet-292	292	28	corresponds	correspond	VERB
admet-292	292	29	to	to	ADP
admet-292	292	30	the	the	DET
admet-292	292	31	continuous	continuous	ADJ
admet-292	292	32	line	line	NOUN
admet-292	292	33	in	in	ADP
admet-292	292	34	figure	figure	NOUN
admet-292	292	35	6	6	NUM
admet-292	292	36	.	.	PUNCT
admet-292	292	37	aqueous	aqueous	ADJ
admet-292	292	38	ph	ph	NOUN
admet-292	292	39	titration	titration	NOUN
admet-292	292	40	was	be	AUX
admet-292	292	41	not	not	PART
admet-292	292	42	used	use	VERB
admet-292	292	43	to	to	PART
admet-292	292	44	determine	determine	VERB
admet-292	292	45	the	the	DET
admet-292	292	46	pka	pka	NOUN
admet-292	292	47	because	because	SCONJ
admet-292	292	48	of	of	ADP
admet-292	292	49	precipitation	precipitation	NOUN
admet-292	292	50	problems	problem	NOUN
admet-292	292	51	.	.	PUNCT
admet-292	293	1	instead	instead	ADV
admet-292	293	2	,	,	PUNCT
admet-292	293	3	several	several	ADJ
admet-292	293	4	titrations	titration	NOUN
admet-292	293	5	were	be	AUX
admet-292	293	6	performed	perform	VERB
admet-292	293	7	at	at	ADP
admet-292	293	8	different	different	ADJ
admet-292	293	9	concentrations	concentration	NOUN
admet-292	293	10	of	of	ADP
admet-292	293	11	co	co	NOUN
admet-292	293	12	-	-	NOUN
admet-292	293	13	solvent	solvent	ADJ
admet-292	293	14	(	(	PUNCT
admet-292	293	15	methanol	methanol	NOUN
admet-292	293	16	)	)	PUNCT
admet-292	293	17	and	and	CCONJ
admet-292	293	18	the	the	DET
admet-292	293	19	aqueous	aqueous	ADJ
admet-292	293	20	pka	pka	PROPN
admet-292	293	21	was	be	AUX
admet-292	293	22	obtained	obtain	VERB
admet-292	293	23	by	by	ADP
admet-292	293	24	extrapolation	extrapolation	NOUN
admet-292	293	25	to	to	ADP
admet-292	293	26	zero	zero	NUM
admet-292	293	27	methanol	methanol	NOUN
admet-292	293	28	concentration	concentration	NOUN
admet-292	293	29	(	(	PUNCT
admet-292	293	30	yasuda	yasuda	NOUN
admet-292	293	31	-	-	PUNCT
admet-292	293	32	shedlovsky	shedlovsky	ADJ
admet-292	293	33	method	method	NOUN
admet-292	293	34	)	)	PUNCT
admet-292	294	1	[	[	X
admet-292	294	2	27	27	NUM
admet-292	294	3	,	,	PUNCT
admet-292	294	4	67	67	NUM
admet-292	294	5	-	-	SYM
admet-292	294	6	69	69	NUM
admet-292	294	7	]	]	PUNCT
admet-292	294	8	.	.	PUNCT
admet-292	295	1	the	the	DET
admet-292	295	2	average	average	ADJ
admet-292	295	3	pka	pka	NOUN
admet-292	295	4	of	of	ADP
admet-292	295	5	4.08	4.08	NUM
admet-292	295	6	±	±	NUM
admet-292	295	7	0.04	0.04	NUM
admet-292	295	8	was	be	AUX
admet-292	295	9	obtained	obtain	VERB
admet-292	295	10	(	(	PUNCT
admet-292	295	11	n=10	n=10	NOUN
admet-292	295	12	,	,	PUNCT
admet-292	295	13	iref	iref	NOUN
admet-292	295	14	=	=	PUNCT
admet-292	295	15	0.15	0.15	NUM
admet-292	295	16	m	m	NOUN
admet-292	295	17	,	,	PUNCT
admet-292	295	18	25	25	NUM
admet-292	295	19	oc	oc	NOUN
admet-292	295	20	)	)	PUNCT
admet-292	295	21	,	,	PUNCT
admet-292	295	22	which	which	PRON
admet-292	295	23	agrees	agree	VERB
admet-292	295	24	closely	closely	ADV
admet-292	295	25	with	with	ADP
admet-292	295	26	previous	previous	ADJ
admet-292	295	27	reported	report	VERB
admet-292	295	28	value	value	NOUN
admet-292	295	29	of	of	ADP
admet-292	295	30	3.99	3.99	NUM
admet-292	295	31	.	.	PUNCT
admet-292	296	1	in	in	ADP
admet-292	296	2	the	the	DET
admet-292	296	3	cheqsol	cheqsol	ADJ
admet-292	296	4	method	method	NOUN
admet-292	296	5	,	,	PUNCT
admet-292	296	6	diclofenac	diclofenac	ADJ
admet-292	296	7	sodium	sodium	NOUN
admet-292	296	8	is	be	AUX
admet-292	296	9	titrated	titrate	VERB
admet-292	296	10	with	with	ADP
admet-292	296	11	standardized	standardized	ADJ
admet-292	296	12	hcl	hcl	PROPN
admet-292	296	13	(	(	PUNCT
admet-292	296	14	figure	figure	NOUN
admet-292	296	15	6	6	NUM
admet-292	296	16	,	,	PUNCT
admet-292	296	17	high	high	ADJ
admet-292	296	18	-	-	PUNCT
admet-292	296	19	to	to	ADP
admet-292	296	20	-	-	PUNCT
admet-292	296	21	low	low	ADJ
admet-292	296	22	ph	ph	ADJ
admet-292	296	23	direction	direction	NOUN
admet-292	296	24	)	)	PUNCT
admet-292	296	25	,	,	PUNCT
admet-292	296	26	until	until	SCONJ
admet-292	296	27	precipitate	precipitate	NOUN
admet-292	296	28	is	be	AUX
admet-292	296	29	turbidimetrically	turbidimetrically	ADV
admet-292	296	30	detected	detect	VERB
admet-292	296	31	(	(	PUNCT
admet-292	296	32	filled	fill	VERB
admet-292	296	33	circles	circle	NOUN
admet-292	296	34	)	)	PUNCT
admet-292	296	35	.	.	PUNCT
admet-292	297	1	at	at	ADP
admet-292	297	2	this	this	DET
admet-292	297	3	point	point	NOUN
admet-292	297	4	the	the	DET
admet-292	297	5	measurements	measurement	NOUN
admet-292	297	6	depart	depart	VERB
admet-292	297	7	suddenly	suddenly	ADV
admet-292	297	8	from	from	ADP
admet-292	297	9	the	the	DET
admet-292	297	10	calculated	calculate	VERB
admet-292	297	11	bjerrum	bjerrum	NOUN
admet-292	297	12	curve	curve	NOUN
admet-292	297	13	,	,	PUNCT
admet-292	297	14	because	because	SCONJ
admet-292	297	15	of	of	ADP
admet-292	297	16	the	the	DET
admet-292	297	17	change	change	NOUN
admet-292	297	18	in	in	ADP
admet-292	297	19	the	the	DET
admet-292	297	20	amount	amount	NOUN
admet-292	297	21	of	of	ADP
admet-292	297	22	dissolved	dissolve	VERB
admet-292	297	23	diclofenac	diclofenac	NOUN
admet-292	297	24	.	.	PUNCT
admet-292	298	1	the	the	DET
admet-292	298	2	solution	solution	NOUN
admet-292	298	3	is	be	AUX
admet-292	298	4	then	then	ADV
admet-292	298	5	repeatedly	repeatedly	ADV
admet-292	298	6	switched	switch	VERB
admet-292	298	7	(	(	PUNCT
admet-292	298	8	by	by	ADP
admet-292	298	9	hcl	hcl	PROPN
admet-292	298	10	/	/	SYM
admet-292	298	11	koh	koh	PROPN
admet-292	298	12	titrant	titrant	PROPN
admet-292	298	13	additions	addition	NOUN
admet-292	298	14	)	)	PUNCT
admet-292	298	15	from	from	ADP
admet-292	298	16	subsaturated	subsaturate	VERB
admet-292	298	17	to	to	ADP
admet-292	298	18	supersaturated	supersaturated	ADJ
admet-292	298	19	states	state	NOUN
admet-292	298	20	(	(	PUNCT
admet-292	298	21	figure	figure	NOUN
admet-292	298	22	7	7	NUM
admet-292	298	23	)	)	PUNCT
admet-292	298	24	,	,	PUNCT
admet-292	298	25	until	until	ADP
admet-292	298	26	the	the	DET
admet-292	298	27	value	value	NOUN
admet-292	298	28	for	for	ADP
admet-292	298	29	the	the	DET
admet-292	298	30	transition	transition	NOUN
admet-292	298	31	between	between	ADP
admet-292	298	32	the	the	DET
admet-292	298	33	states	state	NOUN
admet-292	298	34	,	,	PUNCT
admet-292	298	35	the	the	DET
admet-292	298	36	solubility	solubility	NOUN
admet-292	298	37	estimate	estimate	NOUN
admet-292	298	38	,	,	PUNCT
admet-292	298	39	has	have	AUX
admet-292	298	40	converged	converge	VERB
admet-292	298	41	.	.	PUNCT
admet-292	299	1	the	the	DET
admet-292	299	2	intrinsic	intrinsic	ADJ
admet-292	299	3	solubility	solubility	NOUN
admet-292	299	4	is	be	AUX
admet-292	299	5	calculated	calculate	VERB
admet-292	299	6	as	as	ADP
admet-292	299	7	the	the	DET
admet-292	299	8	mean	mean	ADJ
admet-292	299	9	concentration	concentration	NOUN
admet-292	299	10	of	of	ADP
admet-292	299	11	all	all	DET
admet-292	299	12	the	the	DET
admet-292	299	13	interpolated	interpolate	VERB
admet-292	299	14	crossing	crossing	NOUN
admet-292	299	15	points	point	NOUN
admet-292	299	16	.	.	PUNCT
admet-292	300	1	the	the	DET
admet-292	300	2	bjerrum	bjerrum	NOUN
admet-292	300	3	curve	curve	NOUN
admet-292	300	4	for	for	ADP
admet-292	300	5	the	the	DET
admet-292	300	6	saturated	saturate	VERB
admet-292	300	7	solution	solution	NOUN
admet-292	300	8	is	be	AUX
admet-292	300	9	illustrated	illustrate	VERB
admet-292	300	10	as	as	ADP
admet-292	300	11	the	the	DET
admet-292	300	12	dot	dot	NOUN
admet-292	300	13	-	-	PUNCT
admet-292	300	14	dashed	dash	VERB
admet-292	300	15	line	line	NOUN
admet-292	300	16	in	in	ADP
admet-292	300	17	figure	figure	NOUN
admet-292	300	18	6	6	NUM
admet-292	300	19	.	.	PUNCT
admet-292	301	1	the	the	DET
admet-292	301	2	experiment	experiment	NOUN
admet-292	301	3	was	be	AUX
admet-292	301	4	repeated	repeat	VERB
admet-292	301	5	ten	ten	NUM
admet-292	301	6	times	time	NOUN
admet-292	301	7	and	and	CCONJ
admet-292	301	8	a	a	DET
admet-292	301	9	new	new	ADJ
admet-292	301	10	intrinsic	intrinsic	ADJ
admet-292	301	11	solubility	solubility	NOUN
admet-292	301	12	value	value	NOUN
admet-292	301	13	is	be	AUX
admet-292	301	14	calculated	calculate	VERB
admet-292	301	15	as	as	ADP
admet-292	301	16	the	the	DET
admet-292	301	17	mean	mean	NOUN
admet-292	301	18	of	of	ADP
admet-292	301	19	all	all	DET
admet-292	301	20	ten	ten	NUM
admet-292	301	21	converged	converge	VERB
admet-292	301	22	intrinsic	intrinsic	ADJ
admet-292	301	23	solubility	solubility	NOUN
admet-292	301	24	values	value	NOUN
admet-292	301	25	.	.	PUNCT
admet-292	302	1	alex	alex	PROPN
admet-292	302	2	avdeef	avdeef	PROPN
admet-292	302	3	et	et	PROPN
admet-292	302	4	al	al	PROPN
admet-292	302	5	.	.	PROPN
admet-292	302	6	admet	admet	PROPN
admet-292	302	7	&	&	CCONJ
admet-292	302	8	dmpk	dmpk	PROPN
admet-292	302	9	4(2	4(2	NUM
admet-292	302	10	)	)	PUNCT
admet-292	302	11	(	(	PUNCT
admet-292	302	12	2016	2016	NUM
admet-292	302	13	)	)	PUNCT
admet-292	302	14	117	117	NUM
admet-292	302	15	-	-	SYM
admet-292	302	16	178	178	NUM
admet-292	302	17	132	132	NUM
admet-292	302	18	results	result	NOUN
admet-292	302	19	for	for	ADP
admet-292	302	20	one	one	NUM
admet-292	302	21	solubility	solubility	NOUN
admet-292	302	22	determination	determination	NOUN
admet-292	302	23	of	of	ADP
admet-292	302	24	the	the	DET
admet-292	302	25	sodium	sodium	NOUN
admet-292	302	26	salt	salt	NOUN
admet-292	302	27	of	of	ADP
admet-292	302	28	diclofenac	diclofenac	NOUN
admet-292	302	29	are	be	AUX
admet-292	302	30	illustrated	illustrate	VERB
admet-292	302	31	in	in	ADP
admet-292	302	32	figure	figure	NOUN
admet-292	302	33	7	7	NUM
admet-292	302	34	,	,	PUNCT
admet-292	302	35	which	which	PRON
admet-292	302	36	represents	represent	VERB
admet-292	302	37	the	the	DET
admet-292	302	38	ph	ph	ADJ
admet-292	302	39	gradient	gradient	NOUN
admet-292	302	40	against	against	ADP
admet-292	302	41	the	the	DET
admet-292	302	42	concentration	concentration	NOUN
admet-292	302	43	of	of	ADP
admet-292	302	44	the	the	DET
admet-292	302	45	neutral	neutral	ADJ
admet-292	302	46	species	specie	NOUN
admet-292	302	47	.	.	PUNCT
admet-292	303	1	each	each	DET
admet-292	303	2	crossing	crossing	NOUN
admet-292	303	3	point	point	NOUN
admet-292	303	4	represents	represent	VERB
admet-292	303	5	the	the	DET
admet-292	303	6	transition	transition	NOUN
admet-292	303	7	from	from	ADP
admet-292	303	8	supersaturated	supersaturated	ADJ
admet-292	303	9	to	to	AUX
admet-292	303	10	subsaturated	subsaturate	VERB
admet-292	303	11	(	(	PUNCT
admet-292	303	12	or	or	CCONJ
admet-292	303	13	vice	vice	NOUN
admet-292	303	14	-	-	NOUN
admet-292	303	15	versa	versa	NOUN
admet-292	303	16	)	)	PUNCT
admet-292	303	17	and	and	CCONJ
admet-292	303	18	so	so	ADV
admet-292	303	19	the	the	DET
admet-292	303	20	concentration	concentration	NOUN
admet-292	303	21	of	of	ADP
admet-292	303	22	the	the	DET
admet-292	303	23	neutral	neutral	ADJ
admet-292	303	24	species	specie	NOUN
admet-292	303	25	at	at	ADP
admet-292	303	26	zero	zero	NUM
admet-292	303	27	ph	ph	NOUN
admet-292	303	28	gradient	gradient	NOUN
admet-292	303	29	is	be	AUX
admet-292	303	30	the	the	DET
admet-292	303	31	intrinsic	intrinsic	ADJ
admet-292	303	32	solubility	solubility	NOUN
admet-292	303	33	(	(	PUNCT
admet-292	303	34	s0	s0	PROPN
admet-292	303	35	)	)	PUNCT
admet-292	303	36	of	of	ADP
admet-292	303	37	diclofenac	diclofenac	NOUN
admet-292	303	38	.	.	PUNCT
admet-292	304	1	all	all	DET
admet-292	304	2	crossing	crossing	NOUN
admet-292	304	3	points	point	NOUN
admet-292	304	4	should	should	AUX
admet-292	304	5	lie	lie	VERB
admet-292	304	6	close	close	ADV
admet-292	304	7	together	together	ADV
admet-292	304	8	and	and	CCONJ
admet-292	304	9	give	give	VERB
admet-292	304	10	essentially	essentially	ADV
admet-292	304	11	the	the	DET
admet-292	304	12	same	same	ADJ
admet-292	304	13	answer	answer	NOUN
admet-292	304	14	.	.	PUNCT
admet-292	305	1	the	the	DET
admet-292	305	2	agreement	agreement	NOUN
admet-292	305	3	in	in	ADP
admet-292	305	4	figure	figure	NOUN
admet-292	305	5	7	7	NUM
admet-292	305	6	is	be	AUX
admet-292	305	7	excellent	excellent	ADJ
admet-292	305	8	,	,	PUNCT
admet-292	305	9	with	with	ADP
admet-292	305	10	a	a	DET
admet-292	305	11	coefficient	coefficient	NOUN
admet-292	305	12	of	of	ADP
admet-292	305	13	variation	variation	NOUN
admet-292	305	14	(	(	PUNCT
admet-292	305	15	cv	cv	NOUN
admet-292	305	16	)	)	PUNCT
admet-292	305	17	of	of	ADP
admet-292	305	18	1.2	1.2	NUM
admet-292	305	19	%	%	NOUN
admet-292	305	20	.	.	PUNCT
admet-292	306	1	the	the	DET
admet-292	306	2	spread	spread	NOUN
admet-292	306	3	of	of	ADP
admet-292	306	4	these	these	DET
admet-292	306	5	crossing	crossing	NOUN
admet-292	306	6	points	point	NOUN
admet-292	306	7	is	be	AUX
admet-292	306	8	used	use	VERB
admet-292	306	9	to	to	PART
admet-292	306	10	determine	determine	VERB
admet-292	306	11	the	the	DET
admet-292	306	12	cv	cv	PROPN
admet-292	306	13	of	of	ADP
admet-292	306	14	the	the	DET
admet-292	306	15	mean	mean	ADJ
admet-292	306	16	intrinsic	intrinsic	ADJ
admet-292	306	17	solubility	solubility	NOUN
admet-292	306	18	result	result	NOUN
admet-292	306	19	,	,	PUNCT
admet-292	306	20	and	and	CCONJ
admet-292	306	21	as	as	SCONJ
admet-292	306	22	pointed	point	VERB
admet-292	306	23	out	out	ADP
admet-292	306	24	earlier	early	ADV
admet-292	306	25	,	,	PUNCT
admet-292	306	26	to	to	PART
admet-292	306	27	check	check	VERB
admet-292	306	28	if	if	SCONJ
admet-292	306	29	equilibrium	equilibrium	NOUN
admet-292	306	30	has	have	AUX
admet-292	306	31	been	be	AUX
admet-292	306	32	reached	reach	VERB
admet-292	306	33	.	.	PUNCT
admet-292	307	1	if	if	SCONJ
admet-292	307	2	the	the	DET
admet-292	307	3	crossing	crossing	NOUN
admet-292	307	4	points	point	NOUN
admet-292	307	5	lie	lie	VERB
admet-292	307	6	closely	closely	ADV
admet-292	307	7	together	together	ADV
admet-292	307	8	(	(	PUNCT
admet-292	307	9	low	low	PROPN
admet-292	307	10	cv	cv	PROPN
admet-292	307	11	)	)	PUNCT
admet-292	307	12	this	this	PRON
admet-292	307	13	means	mean	VERB
admet-292	307	14	that	that	SCONJ
admet-292	307	15	the	the	DET
admet-292	307	16	sample	sample	NOUN
admet-292	307	17	is	be	AUX
admet-292	307	18	poised	poise	VERB
admet-292	307	19	at	at	ADP
admet-292	307	20	equilibrium	equilibrium	NOUN
admet-292	307	21	,	,	PUNCT
admet-292	307	22	but	but	CCONJ
admet-292	307	23	if	if	SCONJ
admet-292	307	24	the	the	DET
admet-292	307	25	crossing	crossing	NOUN
admet-292	307	26	points	point	NOUN
admet-292	307	27	are	be	AUX
admet-292	307	28	not	not	PART
admet-292	307	29	in	in	ADP
admet-292	307	30	a	a	DET
admet-292	307	31	tight	tight	ADJ
admet-292	307	32	bunch	bunch	NOUN
admet-292	307	33	(	(	PUNCT
admet-292	307	34	high	high	PROPN
admet-292	307	35	cv	cv	PROPN
admet-292	307	36	)	)	PUNCT
admet-292	307	37	or	or	CCONJ
admet-292	307	38	they	they	PRON
admet-292	307	39	are	be	AUX
admet-292	307	40	not	not	PART
admet-292	307	41	randomly	randomly	ADV
admet-292	307	42	distributed	distribute	VERB
admet-292	307	43	(	(	PUNCT
admet-292	307	44	showing	show	VERB
admet-292	307	45	a	a	DET
admet-292	307	46	tendency	tendency	NOUN
admet-292	307	47	towards	towards	ADP
admet-292	307	48	one	one	NUM
admet-292	307	49	single	single	ADJ
admet-292	307	50	intrinsic	intrinsic	ADJ
admet-292	307	51	solubility	solubility	NOUN
admet-292	307	52	value	value	NOUN
admet-292	307	53	)	)	PUNCT
admet-292	307	54	that	that	PRON
admet-292	307	55	means	mean	VERB
admet-292	307	56	that	that	SCONJ
admet-292	307	57	the	the	DET
admet-292	307	58	system	system	NOUN
admet-292	307	59	needs	need	VERB
admet-292	307	60	more	more	ADJ
admet-292	307	61	time	time	NOUN
admet-292	307	62	to	to	PART
admet-292	307	63	evolve	evolve	VERB
admet-292	307	64	towards	towards	ADP
admet-292	307	65	steady	steady	ADJ
admet-292	307	66	state	state	NOUN
admet-292	307	67	.	.	PUNCT
admet-292	308	1	the	the	DET
admet-292	308	2	diclofenac	diclofenac	PROPN
admet-292	308	3	free	free	ADJ
admet-292	308	4	acid	acid	PROPN
admet-292	308	5	was	be	AUX
admet-292	308	6	isolated	isolate	VERB
admet-292	308	7	by	by	ADP
admet-292	308	8	stopping	stop	VERB
admet-292	308	9	the	the	DET
admet-292	308	10	solubility	solubility	NOUN
admet-292	308	11	experiment	experiment	NOUN
admet-292	308	12	after	after	ADP
admet-292	308	13	eight	eight	NUM
admet-292	308	14	cycles	cycle	NOUN
admet-292	308	15	at	at	ADP
admet-292	308	16	ph	ph	PROPN
admet-292	308	17	6.5	6.5	NUM
admet-292	308	18	.	.	PUNCT
admet-292	309	1	at	at	ADP
admet-292	309	2	this	this	DET
admet-292	309	3	ph	ph	NOUN
admet-292	309	4	and	and	CCONJ
admet-292	309	5	at	at	ADP
admet-292	309	6	the	the	DET
admet-292	309	7	end	end	NOUN
admet-292	309	8	of	of	ADP
admet-292	309	9	the	the	DET
admet-292	309	10	experiment	experiment	NOUN
admet-292	309	11	(	(	PUNCT
admet-292	309	12	60	60	PROPN
admet-292	309	13	min	min	NOUN
admet-292	309	14	)	)	PUNCT
admet-292	309	15	,	,	PUNCT
admet-292	309	16	the	the	DET
admet-292	309	17	solid	solid	ADJ
admet-292	309	18	precipitate	precipitate	NOUN
admet-292	309	19	is	be	AUX
admet-292	309	20	in	in	ADP
admet-292	309	21	equilibrium	equilibrium	NOUN
admet-292	309	22	with	with	ADP
admet-292	309	23	the	the	DET
admet-292	309	24	neutral	neutral	ADJ
admet-292	309	25	form	form	NOUN
admet-292	309	26	in	in	ADP
admet-292	309	27	solution	solution	NOUN
admet-292	309	28	.	.	PUNCT
admet-292	310	1	differential	differential	ADJ
admet-292	310	2	scanning	scan	VERB
admet-292	310	3	calorimetry	calorimetry	NOUN
admet-292	310	4	,	,	PUNCT
admet-292	310	5	thermogravimetric	thermogravimetric	ADJ
admet-292	310	6	analysis	analysis	NOUN
admet-292	310	7	and	and	CCONJ
admet-292	310	8	powder	powder	NOUN
admet-292	310	9	x	x	NOUN
admet-292	310	10	-	-	NOUN
admet-292	310	11	ray	ray	NOUN
admet-292	310	12	diffraction	diffraction	NOUN
admet-292	310	13	were	be	AUX
admet-292	310	14	performed	perform	VERB
admet-292	310	15	on	on	ADP
admet-292	310	16	this	this	DET
admet-292	310	17	precipitate	precipitate	NOUN
admet-292	310	18	in	in	ADP
admet-292	310	19	order	order	NOUN
admet-292	310	20	to	to	PART
admet-292	310	21	fully	fully	ADV
admet-292	310	22	characterize	characterize	VERB
admet-292	310	23	the	the	DET
admet-292	310	24	solid	solid	NOUN
admet-292	310	25	.	.	PUNCT
admet-292	311	1	the	the	DET
admet-292	311	2	crystal	crystal	NOUN
admet-292	311	3	structure	structure	NOUN
admet-292	311	4	of	of	ADP
admet-292	311	5	this	this	DET
admet-292	311	6	solid	solid	NOUN
admet-292	311	7	corresponded	correspond	VERB
admet-292	311	8	to	to	ADP
admet-292	311	9	the	the	DET
admet-292	311	10	structure	structure	NOUN
admet-292	311	11	siklih01	siklih01	NOUN
admet-292	311	12	(	(	PUNCT
admet-292	311	13	cambridge	cambridge	PROPN
admet-292	311	14	structural	structural	ADJ
admet-292	311	15	database	database	NOUN
admet-292	311	16	)	)	PUNCT
admet-292	312	1	[	[	X
admet-292	312	2	70	70	NUM
admet-292	312	3	]	]	PUNCT
admet-292	312	4	.	.	PUNCT
admet-292	313	1	characterization	characterization	NOUN
admet-292	313	2	showed	show	VERB
admet-292	313	3	that	that	SCONJ
admet-292	313	4	the	the	DET
admet-292	313	5	precipitated	precipitate	VERB
admet-292	313	6	solid	solid	ADJ
admet-292	313	7	is	be	AUX
admet-292	313	8	the	the	DET
admet-292	313	9	anhydrous	anhydrous	ADJ
admet-292	313	10	form	form	NOUN
admet-292	313	11	of	of	ADP
admet-292	313	12	the	the	DET
admet-292	313	13	acid	acid	NOUN
admet-292	313	14	of	of	ADP
admet-292	313	15	diclofenac	diclofenac	NOUN
admet-292	313	16	,	,	PUNCT
admet-292	313	17	space	space	NOUN
admet-292	313	18	group	group	NOUN
admet-292	313	19	c2	c2	PROPN
admet-292	313	20	/	/	SYM
admet-292	313	21	c	c	PROPN
admet-292	313	22	,	,	PUNCT
admet-292	313	23	with	with	ADP
admet-292	313	24	an	an	DET
admet-292	313	25	observed	observed	ADJ
admet-292	313	26	melting	melting	NOUN
admet-292	313	27	point	point	NOUN
admet-292	313	28	of	of	ADP
admet-292	313	29	180.5	180.5	NUM
admet-292	313	30	°	°	NOUN
admet-292	313	31	c	c	NOUN
admet-292	313	32	.	.	PUNCT
admet-292	314	1	potentiometric	potentiometric	ADJ
admet-292	314	2	cycling	cycling	NOUN
admet-292	314	3	for	for	ADP
admet-292	314	4	polymorph	polymorph	NOUN
admet-292	314	5	creation	creation	NOUN
admet-292	314	6	,	,	PUNCT
admet-292	314	7	[	[	X
admet-292	314	8	pc]2	pc]2	ADP
admet-292	314	9	any	any	DET
admet-292	314	10	solubility	solubility	NOUN
admet-292	314	11	measurement	measurement	NOUN
admet-292	314	12	depends	depend	VERB
admet-292	314	13	on	on	ADP
admet-292	314	14	the	the	DET
admet-292	314	15	form	form	NOUN
admet-292	314	16	of	of	ADP
admet-292	314	17	the	the	DET
admet-292	314	18	solid	solid	ADJ
admet-292	314	19	in	in	ADP
admet-292	314	20	equilibrium	equilibrium	NOUN
admet-292	314	21	with	with	ADP
admet-292	314	22	its	its	PRON
admet-292	314	23	saturated	saturate	VERB
admet-292	314	24	solution	solution	NOUN
admet-292	314	25	.	.	PUNCT
admet-292	315	1	it	it	PRON
admet-292	315	2	is	be	AUX
admet-292	315	3	therefore	therefore	ADV
admet-292	315	4	not	not	PART
admet-292	315	5	enough	enough	ADJ
admet-292	315	6	to	to	PART
admet-292	315	7	know	know	VERB
admet-292	315	8	the	the	DET
admet-292	315	9	solid	solid	ADJ
admet-292	315	10	form	form	NOUN
admet-292	315	11	of	of	ADP
admet-292	315	12	the	the	DET
admet-292	315	13	material	material	NOUN
admet-292	315	14	at	at	ADP
admet-292	315	15	the	the	DET
admet-292	315	16	beginning	beginning	NOUN
admet-292	315	17	of	of	ADP
admet-292	315	18	the	the	DET
admet-292	315	19	experiment	experiment	NOUN
admet-292	315	20	.	.	PUNCT
admet-292	316	1	using	use	VERB
admet-292	316	2	the	the	DET
admet-292	316	3	cheqsol	cheqsol	ADJ
admet-292	316	4	method	method	NOUN
admet-292	316	5	one	one	PRON
admet-292	316	6	avoids	avoid	VERB
admet-292	316	7	the	the	DET
admet-292	316	8	possibility	possibility	NOUN
admet-292	316	9	of	of	ADP
admet-292	316	10	confounding	confound	VERB
admet-292	316	11	different	different	ADJ
admet-292	316	12	forms	form	NOUN
admet-292	316	13	precipitating	precipitate	VERB
admet-292	316	14	,	,	PUNCT
admet-292	316	15	and	and	CCONJ
admet-292	316	16	therefore	therefore	ADV
admet-292	316	17	reporting	report	VERB
admet-292	316	18	misleading	mislead	VERB
admet-292	316	19	data	datum	NOUN
admet-292	316	20	(	(	PUNCT
admet-292	316	21	i.e.	i.e.	X
admet-292	316	22	,	,	PUNCT
admet-292	316	23	amorphous	amorphous	ADJ
admet-292	316	24	vs	vs	ADP
admet-292	316	25	crystalline	crystalline	NOUN
admet-292	316	26	,	,	PUNCT
admet-292	316	27	salts	salt	NOUN
admet-292	316	28	vs	vs	ADP
admet-292	316	29	neutral	neutral	ADJ
admet-292	316	30	forms	form	NOUN
admet-292	316	31	,	,	PUNCT
admet-292	316	32	hydrates	hydrate	NOUN
admet-292	316	33	vs	vs	ADP
admet-292	316	34	anhydrous	anhydrous	NOUN
admet-292	316	35	...	...	PUNCT
admet-292	316	36	)	)	PUNCT
admet-292	316	37	.	.	PUNCT
admet-292	317	1	pudipeddi	pudipeddi	NOUN
admet-292	317	2	and	and	CCONJ
admet-292	317	3	serajuddin	serajuddin	PROPN
admet-292	317	4	published	publish	VERB
admet-292	317	5	a	a	DET
admet-292	317	6	survey	survey	NOUN
admet-292	317	7	in	in	ADP
admet-292	317	8	2005	2005	NUM
admet-292	317	9	,	,	PUNCT
admet-292	317	10	showing	show	VERB
admet-292	317	11	that	that	SCONJ
admet-292	317	12	the	the	DET
admet-292	317	13	difference	difference	NOUN
admet-292	317	14	in	in	ADP
admet-292	317	15	solubility	solubility	NOUN
admet-292	317	16	of	of	ADP
admet-292	317	17	polymorphs	polymorphs	NOUN
admet-292	317	18	is	be	AUX
admet-292	317	19	usually	usually	ADV
admet-292	317	20	less	less	ADJ
admet-292	317	21	than	than	ADP
admet-292	317	22	a	a	DET
admet-292	317	23	factor	factor	NOUN
admet-292	317	24	of	of	ADP
admet-292	317	25	two	two	NUM
admet-292	317	26	[	[	X
admet-292	317	27	18	18	NUM
admet-292	317	28	]	]	PUNCT
admet-292	317	29	.	.	PUNCT
admet-292	318	1	however	however	ADV
admet-292	318	2	our	our	PRON
admet-292	318	3	results	result	NOUN
admet-292	318	4	suggest	suggest	VERB
admet-292	318	5	that	that	SCONJ
admet-292	318	6	polymorphs	polymorphs	NOUN
admet-292	318	7	[	[	X
admet-292	318	8	71	71	NUM
admet-292	318	9	]	]	PUNCT
admet-292	318	10	can	can	AUX
admet-292	318	11	have	have	VERB
admet-292	318	12	a	a	DET
admet-292	318	13	considerably	considerably	ADV
admet-292	318	14	greater	great	ADJ
admet-292	318	15	factor	factor	NOUN
admet-292	318	16	than	than	ADP
admet-292	318	17	this	this	PRON
admet-292	318	18	.	.	PUNCT
admet-292	319	1	it	it	PRON
admet-292	319	2	is	be	AUX
admet-292	319	3	therefore	therefore	ADV
admet-292	319	4	of	of	ADP
admet-292	319	5	vital	vital	ADJ
admet-292	319	6	importance	importance	NOUN
admet-292	319	7	to	to	PART
admet-292	319	8	properly	properly	ADV
admet-292	319	9	characterize	characterize	VERB
admet-292	319	10	the	the	DET
admet-292	319	11	solid	solid	ADJ
admet-292	319	12	form	form	NOUN
admet-292	319	13	,	,	PUNCT
admet-292	319	14	the	the	DET
admet-292	319	15	solubility	solubility	NOUN
admet-292	319	16	of	of	ADP
admet-292	319	17	which	which	PRON
admet-292	319	18	is	be	AUX
admet-292	319	19	reported	report	VERB
admet-292	319	20	,	,	PUNCT
admet-292	319	21	but	but	CCONJ
admet-292	319	22	this	this	PRON
admet-292	319	23	is	be	AUX
admet-292	319	24	rarely	rarely	ADV
admet-292	319	25	done	do	VERB
admet-292	319	26	in	in	ADP
admet-292	319	27	the	the	DET
admet-292	319	28	literature	literature	NOUN
admet-292	319	29	.	.	PUNCT
admet-292	320	1	cheqsol	cheqsol	PROPN
admet-292	320	2	can	can	AUX
admet-292	320	3	be	be	AUX
admet-292	320	4	used	use	VERB
admet-292	320	5	to	to	PART
admet-292	320	6	parse	parse	VERB
admet-292	320	7	the	the	DET
admet-292	320	8	entire	entire	ADJ
admet-292	320	9	meta	meta	ADJ
admet-292	320	10	stable	stable	ADJ
admet-292	320	11	zone	zone	NOUN
admet-292	320	12	(	(	PUNCT
admet-292	320	13	msz	msz	NOUN
admet-292	320	14	)	)	PUNCT
admet-292	320	15	shown	show	VERB
admet-292	320	16	in	in	ADP
admet-292	320	17	figure	figure	NOUN
admet-292	320	18	8	8	NUM
admet-292	320	19	,	,	PUNCT
admet-292	320	20	starting	start	VERB
admet-292	320	21	from	from	ADP
admet-292	320	22	the	the	DET
admet-292	320	23	first	first	ADJ
admet-292	320	24	form	form	NOUN
admet-292	320	25	precipitating	precipitate	VERB
admet-292	320	26	at	at	ADP
admet-292	320	27	high	high	ADJ
admet-292	320	28	supersaturation	supersaturation	NOUN
admet-292	320	29	,	,	PUNCT
admet-292	320	30	which	which	PRON
admet-292	320	31	is	be	AUX
admet-292	320	32	the	the	DET
admet-292	320	33	highest	high	ADJ
admet-292	320	34	energy	energy	NOUN
admet-292	320	35	polymorph	polymorph	NOUN
admet-292	320	36	(	(	PUNCT
admet-292	320	37	kinetically	kinetically	ADV
admet-292	320	38	driven	drive	VERB
admet-292	320	39	)	)	PUNCT
admet-292	320	40	,	,	PUNCT
admet-292	320	41	down	down	ADP
admet-292	320	42	to	to	ADP
admet-292	320	43	the	the	DET
admet-292	320	44	last	last	ADJ
admet-292	320	45	most	most	ADV
admet-292	320	46	stable	stable	ADJ
admet-292	320	47	form	form	NOUN
admet-292	320	48	on	on	ADP
admet-292	320	49	the	the	DET
admet-292	320	50	thermodynamic	thermodynamic	ADJ
admet-292	320	51	solubility	solubility	NOUN
admet-292	320	52	saturation	saturation	NOUN
admet-292	320	53	curve	curve	NOUN
admet-292	320	54	(	(	PUNCT
admet-292	320	55	thermodynamically	thermodynamically	ADV
admet-292	320	56	driven	drive	VERB
admet-292	320	57	)	)	PUNCT
admet-292	320	58	and	and	CCONJ
admet-292	320	59	achieved	achieve	VERB
admet-292	320	60	by	by	ADP
admet-292	320	61	cycling	cycle	VERB
admet-292	320	62	the	the	DET
admet-292	320	63	system	system	NOUN
admet-292	320	64	many	many	ADJ
admet-292	320	65	times	time	NOUN
admet-292	320	66	between	between	ADP
admet-292	320	67	supersaturation	supersaturation	NOUN
admet-292	320	68	and	and	CCONJ
admet-292	320	69	subsaturation	subsaturation	NOUN
admet-292	320	70	.	.	PUNCT
admet-292	321	1	this	this	DET
admet-292	321	2	transition	transition	NOUN
admet-292	321	3	is	be	AUX
admet-292	321	4	normally	normally	ADV
admet-292	321	5	seen	see	VERB
admet-292	321	6	as	as	ADP
admet-292	321	7	a	a	DET
admet-292	321	8	continuous	continuous	ADJ
admet-292	321	9	transition	transition	NOUN
admet-292	321	10	from	from	ADP
admet-292	321	11	the	the	DET
admet-292	321	12	first	first	ADJ
admet-292	321	13	precipitate	precipitate	NOUN
admet-292	321	14	to	to	ADP
admet-292	321	15	the	the	DET
admet-292	321	16	most	most	ADV
admet-292	321	17	stable	stable	ADJ
admet-292	321	18	form	form	NOUN
admet-292	321	19	,	,	PUNCT
admet-292	321	20	following	follow	VERB
admet-292	321	21	ostwald	ostwald	NOUN
admet-292	321	22	’s	’s	PART
admet-292	321	23	rule	rule	NOUN
admet-292	321	24	(	(	PUNCT
admet-292	321	25	see	see	VERB
admet-292	321	26	figure	figure	NOUN
admet-292	321	27	8)	8)	NUM
admet-292	321	28	.	.	PUNCT
admet-292	322	1	metastable	metastable	ADJ
admet-292	322	2	polymorphs	polymorph	NOUN
admet-292	322	3	encountered	encounter	VERB
admet-292	322	4	during	during	ADP
admet-292	322	5	this	this	DET
admet-292	322	6	path	path	NOUN
admet-292	322	7	are	be	AUX
admet-292	322	8	not	not	PART
admet-292	322	9	,	,	PUNCT
admet-292	322	10	in	in	ADP
admet-292	322	11	general	general	ADJ
admet-292	322	12	,	,	PUNCT
admet-292	322	13	stable	stable	ADJ
admet-292	322	14	enough	enough	ADV
admet-292	322	15	to	to	PART
admet-292	322	16	isolate	isolate	VERB
admet-292	322	17	and	and	CCONJ
admet-292	322	18	characterize	characterize	VERB
admet-292	322	19	,	,	PUNCT
admet-292	322	20	but	but	CCONJ
admet-292	322	21	sometimes	sometimes	ADV
admet-292	322	22	a	a	DET
admet-292	322	23	metastable	metastable	ADJ
admet-292	322	24	polymorph	polymorph	NOUN
admet-292	322	25	arises	arise	VERB
admet-292	322	26	during	during	ADP
admet-292	322	27	this	this	DET
admet-292	322	28	process	process	NOUN
admet-292	322	29	,	,	PUNCT
admet-292	322	30	being	be	AUX
admet-292	322	31	stable	stable	ADJ
admet-292	322	32	enough	enough	ADV
admet-292	322	33	to	to	PART
admet-292	322	34	reach	reach	VERB
admet-292	322	35	a	a	DET
admet-292	322	36	100	100	NUM
admet-292	322	37	%	%	NOUN
admet-292	322	38	of	of	ADP
admet-292	322	39	this	this	DET
admet-292	322	40	metastable	metastable	ADJ
admet-292	322	41	polymorph	polymorph	NOUN
admet-292	322	42	,	,	PUNCT
admet-292	322	43	which	which	PRON
admet-292	322	44	then	then	ADV
admet-292	322	45	can	can	AUX
admet-292	322	46	be	be	AUX
admet-292	322	47	isolated	isolate	VERB
admet-292	322	48	and	and	CCONJ
admet-292	322	49	characterized	characterize	VERB
admet-292	322	50	.	.	PUNCT
admet-292	323	1	nevertheless	nevertheless	ADV
admet-292	323	2	,	,	PUNCT
admet-292	323	3	if	if	SCONJ
admet-292	323	4	one	one	PRON
admet-292	323	5	continues	continue	VERB
admet-292	323	6	cycling	cycling	NOUN
admet-292	323	7	between	between	ADP
admet-292	323	8	supersaturated	supersaturated	ADJ
admet-292	323	9	solution	solution	NOUN
admet-292	323	10	and	and	CCONJ
admet-292	323	11	subsaturated	subsaturate	VERB
admet-292	323	12	solution	solution	NOUN
admet-292	323	13	,	,	PUNCT
admet-292	323	14	this	this	DET
admet-292	323	15	metastable	metastable	ADJ
admet-292	323	16	form	form	NOUN
admet-292	323	17	will	will	AUX
admet-292	323	18	evolve	evolve	VERB
admet-292	323	19	towards	towards	ADP
admet-292	323	20	the	the	DET
admet-292	323	21	most	most	ADV
admet-292	323	22	stable	stable	ADJ
admet-292	323	23	one	one	NOUN
admet-292	323	24	,	,	PUNCT
admet-292	323	25	which	which	PRON
admet-292	323	26	will	will	AUX
admet-292	323	27	not	not	PART
admet-292	323	28	change	change	VERB
admet-292	323	29	in	in	ADP
admet-292	323	30	form	form	NOUN
admet-292	323	31	under	under	ADP
admet-292	323	32	the	the	DET
admet-292	323	33	cycling	cycling	NOUN
admet-292	323	34	process	process	NOUN
admet-292	323	35	.	.	PUNCT
admet-292	324	1	it	it	PRON
admet-292	324	2	’s	’	VERB
admet-292	324	3	an	an	DET
admet-292	324	4	advantage	advantage	NOUN
admet-292	324	5	that	that	SCONJ
admet-292	324	6	these	these	DET
admet-292	324	7	polymorph	polymorph	NOUN
admet-292	324	8	transformations	transformation	NOUN
admet-292	324	9	can	can	AUX
admet-292	324	10	be	be	AUX
admet-292	324	11	followed	follow	VERB
admet-292	324	12	in	in	ADP
admet-292	324	13	real	real	ADJ
admet-292	324	14	time	time	NOUN
admet-292	324	15	,	,	PUNCT
admet-292	324	16	when	when	SCONJ
admet-292	324	17	the	the	DET
admet-292	324	18	solubility	solubility	NOUN
admet-292	324	19	can	can	AUX
admet-292	324	20	be	be	AUX
admet-292	324	21	measured	measure	VERB
admet-292	324	22	for	for	ADP
admet-292	324	23	each	each	DET
admet-292	324	24	different	different	ADJ
admet-292	324	25	form	form	NOUN
admet-292	324	26	,	,	PUNCT
admet-292	324	27	by	by	ADP
admet-292	324	28	stopping	stop	VERB
admet-292	324	29	the	the	DET
admet-292	324	30	cycling	cycling	NOUN
admet-292	324	31	at	at	ADP
admet-292	324	32	a	a	DET
admet-292	324	33	specific	specific	ADJ
admet-292	324	34	ph	ph	NOUN
admet-292	324	35	,	,	PUNCT
admet-292	324	36	collecting	collect	VERB
admet-292	324	37	the	the	DET
admet-292	324	38	solid	solid	ADJ
admet-292	324	39	and	and	CCONJ
admet-292	324	40	characterizing	characterize	VERB
admet-292	324	41	it	it	PRON
admet-292	324	42	by	by	ADP
admet-292	324	43	several	several	ADJ
admet-292	324	44	techniques	technique	NOUN
admet-292	324	45	.	.	PUNCT
admet-292	325	1	this	this	DET
admet-292	325	2	cycling	cycling	NOUN
admet-292	325	3	method	method	NOUN
admet-292	325	4	has	have	AUX
admet-292	325	5	been	be	AUX
admet-292	325	6	called	call	VERB
admet-292	325	7	“	"	PUNCT
admet-292	325	8	potentiometric	potentiometric	ADJ
admet-292	325	9	cycling	cycling	NOUN
admet-292	325	10	for	for	ADP
admet-292	325	11	polymorph	polymorph	NOUN
admet-292	325	12	creation	creation	NOUN
admet-292	325	13	”	"	PUNCT
admet-292	326	1	[	[	X
admet-292	326	2	pc]2	pc]2	X
admet-292	326	3	.	.	PUNCT
admet-292	326	4	admet	admet	PROPN
admet-292	326	5	&	&	CCONJ
admet-292	326	6	dmpk	dmpk	PROPN
admet-292	326	7	4(2	4(2	NUM
admet-292	326	8	)	)	PUNCT
admet-292	326	9	(	(	PUNCT
admet-292	326	10	2016	2016	NUM
admet-292	326	11	)	)	PUNCT
admet-292	326	12	117	117	NUM
admet-292	326	13	-	-	SYM
admet-292	326	14	178	178	NUM
admet-292	326	15	consensus	consensus	NOUN
admet-292	326	16	recommendations	recommendation	NOUN
admet-292	326	17	for	for	ADP
admet-292	326	18	improving	improve	VERB
admet-292	326	19	solubility	solubility	NOUN
admet-292	326	20	-	-	PUNCT
admet-292	326	21	ph	ph	ADJ
admet-292	326	22	data	datum	NOUN
admet-292	326	23	quality	quality	NOUN
admet-292	326	24	doi	doi	NOUN
admet-292	326	25	:	:	PUNCT
admet-292	326	26	10.5599	10.5599	NUM
admet-292	326	27	/	/	SYM
admet-292	326	28	admet.4.2.292	admet.4.2.292	NUM
admet-292	326	29	133	133	NUM
admet-292	326	30	figure	figure	NOUN
admet-292	326	31	8	8	NUM
admet-292	326	32	.	.	PUNCT
admet-292	326	33	supersaturation	supersaturation	NOUN
admet-292	326	34	and	and	CCONJ
admet-292	326	35	oswald	oswald	NOUN
admet-292	326	36	ripening	ripening	NOUN
admet-292	326	37	.	.	PUNCT
admet-292	327	1	this	this	DET
admet-292	327	2	transformation	transformation	NOUN
admet-292	327	3	can	can	AUX
admet-292	327	4	also	also	ADV
admet-292	327	5	be	be	AUX
admet-292	327	6	followed	follow	VERB
admet-292	327	7	in	in	ADP
admet-292	327	8	real	real	ADJ
admet-292	327	9	time	time	NOUN
admet-292	327	10	using	use	VERB
admet-292	327	11	a	a	DET
admet-292	327	12	raman	raman	NOUN
admet-292	327	13	probe	probe	NOUN
admet-292	327	14	coupled	couple	VERB
admet-292	327	15	to	to	ADP
admet-292	327	16	the	the	DET
admet-292	327	17	potentiometric	potentiometric	ADJ
admet-292	327	18	instrument	instrument	NOUN
admet-292	327	19	enabling	enable	VERB
admet-292	327	20	one	one	NUM
admet-292	327	21	to	to	PART
admet-292	327	22	follow	follow	VERB
admet-292	327	23	these	these	DET
admet-292	327	24	phase	phase	NOUN
admet-292	327	25	transitions	transition	NOUN
admet-292	327	26	without	without	ADP
admet-292	327	27	the	the	DET
admet-292	327	28	need	need	NOUN
admet-292	327	29	of	of	ADP
admet-292	327	30	stopping	stop	VERB
admet-292	327	31	the	the	DET
admet-292	327	32	experiment	experiment	NOUN
admet-292	327	33	and	and	CCONJ
admet-292	327	34	isolating	isolate	VERB
admet-292	327	35	the	the	DET
admet-292	327	36	solid	solid	NOUN
admet-292	327	37	.	.	PUNCT
admet-292	328	1	this	this	DET
admet-292	328	2	technique	technique	NOUN
admet-292	328	3	allows	allow	VERB
admet-292	328	4	one	one	PRON
admet-292	328	5	to	to	PART
admet-292	328	6	have	have	VERB
admet-292	328	7	a	a	DET
admet-292	328	8	precise	precise	ADJ
admet-292	328	9	control	control	NOUN
admet-292	328	10	of	of	ADP
admet-292	328	11	the	the	DET
admet-292	328	12	rate	rate	NOUN
admet-292	328	13	of	of	ADP
admet-292	328	14	transformation	transformation	NOUN
admet-292	328	15	of	of	ADP
admet-292	328	16	one	one	NUM
admet-292	328	17	form	form	NOUN
admet-292	328	18	into	into	ADP
admet-292	328	19	the	the	DET
admet-292	328	20	other	other	ADJ
admet-292	328	21	,	,	PUNCT
admet-292	328	22	depending	depend	VERB
admet-292	328	23	on	on	ADP
admet-292	328	24	the	the	DET
admet-292	328	25	conditions	condition	NOUN
admet-292	328	26	of	of	ADP
admet-292	328	27	the	the	DET
admet-292	328	28	experiment	experiment	NOUN
admet-292	328	29	used	use	VERB
admet-292	328	30	.	.	PUNCT
admet-292	329	1	figure	figure	NOUN
admet-292	329	2	9	9	NUM
admet-292	329	3	.	.	PUNCT
admet-292	329	4	bjerrum	bjerrum	NOUN
admet-292	329	5	curve	curve	NOUN
admet-292	329	6	for	for	ADP
admet-292	329	7	sulindac	sulindac	NOUN
admet-292	329	8	depicting	depict	VERB
admet-292	329	9	the	the	DET
admet-292	329	10	first	first	ADJ
admet-292	329	11	(	(	PUNCT
admet-292	329	12	form	form	NOUN
admet-292	329	13	i	i	NOUN
admet-292	329	14	)	)	PUNCT
admet-292	329	15	and	and	CCONJ
admet-292	329	16	equilibrium	equilibrium	NOUN
admet-292	329	17	cycling	cycling	NOUN
admet-292	329	18	(	(	PUNCT
admet-292	329	19	form	form	NOUN
admet-292	329	20	ii	ii	NOUN
admet-292	329	21	)	)	PUNCT
admet-292	329	22	.	.	PUNCT
admet-292	330	1	figure	figure	NOUN
admet-292	330	2	on	on	ADP
admet-292	330	3	the	the	DET
admet-292	330	4	right	right	NOUN
admet-292	330	5	shows	show	VERB
admet-292	330	6	the	the	DET
admet-292	330	7	evolution	evolution	NOUN
admet-292	330	8	of	of	ADP
admet-292	330	9	the	the	DET
admet-292	330	10	ph	ph	NOUN
admet-292	330	11	gradient	gradient	NOUN
admet-292	330	12	as	as	ADP
admet-292	330	13	the	the	DET
admet-292	330	14	experiment	experiment	NOUN
admet-292	330	15	progress	progress	NOUN
admet-292	330	16	.	.	PUNCT
admet-292	331	1	note	note	VERB
admet-292	331	2	how	how	SCONJ
admet-292	331	3	the	the	DET
admet-292	331	4	first	first	ADJ
admet-292	331	5	precipitate	precipitate	NOUN
admet-292	331	6	form	form	NOUN
admet-292	331	7	i	i	PRON
admet-292	331	8	has	have	VERB
admet-292	331	9	a	a	DET
admet-292	331	10	solubility	solubility	NOUN
admet-292	331	11	around	around	ADP
admet-292	331	12	70	70	NUM
admet-292	331	13	μg	μg	NOUN
admet-292	331	14	/	/	SYM
admet-292	331	15	ml	ml	NOUN
admet-292	331	16	,	,	PUNCT
admet-292	331	17	while	while	SCONJ
admet-292	331	18	the	the	DET
admet-292	331	19	most	most	ADV
admet-292	331	20	stable	stable	ADJ
admet-292	331	21	form	form	NOUN
admet-292	331	22	,	,	PUNCT
admet-292	331	23	form	form	NOUN
admet-292	331	24	ii	ii	PROPN
admet-292	331	25	,	,	PUNCT
admet-292	331	26	stablishes	stablishe	VERB
admet-292	331	27	the	the	DET
admet-292	331	28	cycling	cycling	NOUN
admet-292	331	29	on	on	ADP
admet-292	331	30	a	a	DET
admet-292	331	31	value	value	NOUN
admet-292	331	32	around	around	ADP
admet-292	331	33	10	10	NUM
admet-292	331	34	μg	μg	NOUN
admet-292	331	35	/	/	SYM
admet-292	331	36	ml	ml	PROPN
admet-292	331	37	.	.	PUNCT
admet-292	332	1	this	this	DET
admet-292	332	2	approach	approach	NOUN
admet-292	332	3	has	have	AUX
admet-292	332	4	been	be	AUX
admet-292	332	5	applied	apply	VERB
admet-292	332	6	to	to	ADP
admet-292	332	7	numerous	numerous	ADJ
admet-292	332	8	compounds	compound	NOUN
admet-292	332	9	(	(	PUNCT
admet-292	332	10	bases	basis	NOUN
admet-292	332	11	,	,	PUNCT
admet-292	332	12	acids	acid	NOUN
admet-292	332	13	and	and	CCONJ
admet-292	332	14	zwitterions	zwitterion	NOUN
admet-292	332	15	)	)	PUNCT
admet-292	332	16	,	,	PUNCT
admet-292	332	17	generally	generally	ADV
admet-292	332	18	obtaining	obtain	VERB
admet-292	332	19	the	the	DET
admet-292	332	20	more	more	ADV
admet-292	332	21	stable	stable	ADJ
admet-292	332	22	polymorph	polymorph	NOUN
admet-292	332	23	;	;	PUNCT
admet-292	332	24	in	in	ADP
admet-292	332	25	many	many	ADJ
admet-292	332	26	cases	case	NOUN
admet-292	332	27	they	they	PRON
admet-292	332	28	proved	prove	VERB
admet-292	332	29	to	to	PART
admet-292	332	30	be	be	AUX
admet-292	332	31	newly	newly	ADV
admet-292	332	32	-	-	PUNCT
admet-292	332	33	identified	identify	VERB
admet-292	332	34	polymorphs	polymorphs	NOUN
admet-292	332	35	[	[	X
admet-292	332	36	1	1	NUM
admet-292	332	37	,	,	PUNCT
admet-292	332	38	66	66	NUM
admet-292	332	39	,	,	PUNCT
admet-292	332	40	71	71	NUM
admet-292	332	41	-	-	SYM
admet-292	332	42	74	74	NUM
admet-292	332	43	]	]	PUNCT
admet-292	332	44	.	.	PUNCT
admet-292	333	1	sulindac	sulindac	PROPN
admet-292	333	2	exemplifies	exemplify	VERB
admet-292	333	3	the	the	DET
admet-292	333	4	[	[	NOUN
admet-292	333	5	pc]2	pc]2	ADJ
admet-292	333	6	approach	approach	NOUN
admet-292	333	7	[	[	X
admet-292	333	8	73	73	NUM
admet-292	333	9	]	]	PUNCT
admet-292	333	10	.	.	PUNCT
admet-292	334	1	at	at	ADP
admet-292	334	2	first	first	ADV
admet-292	334	3	the	the	DET
admet-292	334	4	experiment	experiment	NOUN
admet-292	334	5	produced	produce	VERB
admet-292	334	6	measurements	measurement	NOUN
admet-292	334	7	following	follow	VERB
admet-292	334	8	the	the	DET
admet-292	334	9	usual	usual	ADJ
admet-292	334	10	pattern	pattern	NOUN
admet-292	334	11	of	of	ADP
admet-292	334	12	a	a	DET
admet-292	334	13	cheqsol	cheqsol	ADJ
admet-292	334	14	experiment	experiment	NOUN
admet-292	334	15	and	and	CCONJ
admet-292	334	16	the	the	DET
admet-292	334	17	readings	reading	NOUN
admet-292	334	18	converged	converge	VERB
admet-292	334	19	on	on	ADP
admet-292	334	20	an	an	DET
admet-292	334	21	intrinsic	intrinsic	ADJ
admet-292	334	22	solubility	solubility	NOUN
admet-292	334	23	of	of	ADP
admet-292	334	24	70	70	NUM
admet-292	334	25	μg	μg	NOUN
admet-292	334	26	/	/	SYM
admet-292	334	27	ml	ml	PROPN
admet-292	334	28	(	(	PUNCT
admet-292	334	29	figure	figure	NOUN
admet-292	334	30	9	9	NUM
admet-292	334	31	)	)	PUNCT
admet-292	334	32	.	.	PUNCT
admet-292	335	1	the	the	DET
admet-292	335	2	crystalline	crystalline	PROPN
admet-292	335	3	precipitate	precipitate	NOUN
admet-292	335	4	(	(	PUNCT
admet-292	335	5	form	form	VERB
admet-292	335	6	i	i	PRON
admet-292	335	7	in	in	ADP
admet-292	335	8	figure	figure	NOUN
admet-292	335	9	9	9	NUM
admet-292	335	10	)	)	PUNCT
admet-292	335	11	was	be	AUX
admet-292	335	12	then	then	ADV
admet-292	335	13	isolated	isolate	VERB
admet-292	335	14	and	and	CCONJ
admet-292	335	15	characterized	characterize	VERB
admet-292	335	16	by	by	ADP
admet-292	335	17	powder	powder	NOUN
admet-292	335	18	x	x	NOUN
admet-292	335	19	-	-	NOUN
admet-292	335	20	ray	ray	NOUN
admet-292	335	21	diffraction	diffraction	NOUN
admet-292	335	22	(	(	PUNCT
admet-292	335	23	pxrd	pxrd	PROPN
admet-292	335	24	)	)	PUNCT
admet-292	335	25	,	,	PUNCT
admet-292	335	26	raman	raman	NOUN
admet-292	335	27	spectroscopy	spectroscopy	NOUN
admet-292	335	28	,	,	PUNCT
admet-292	335	29	infrared	infrared	ADJ
admet-292	335	30	spectroscopy	spectroscopy	NOUN
admet-292	335	31	(	(	PUNCT
admet-292	335	32	ir	ir	NOUN
admet-292	335	33	)	)	PUNCT
admet-292	335	34	,	,	PUNCT
admet-292	335	35	thermogravimetry	thermogravimetry	NOUN
admet-292	335	36	analysis	analysis	NOUN
admet-292	335	37	(	(	PUNCT
admet-292	335	38	tga	tga	NOUN
admet-292	335	39	)	)	PUNCT
admet-292	335	40	and	and	CCONJ
admet-292	335	41	alex	alex	PROPN
admet-292	335	42	avdeef	avdeef	PROPN
admet-292	335	43	et	et	PROPN
admet-292	335	44	al	al	PROPN
admet-292	335	45	.	.	PROPN
admet-292	335	46	admet	admet	PROPN
admet-292	335	47	&	&	CCONJ
admet-292	335	48	dmpk	dmpk	PROPN
admet-292	335	49	4(2	4(2	NUM
admet-292	335	50	)	)	PUNCT
admet-292	335	51	(	(	PUNCT
admet-292	335	52	2016	2016	NUM
admet-292	335	53	)	)	PUNCT
admet-292	335	54	117	117	NUM
admet-292	335	55	-	-	SYM
admet-292	335	56	178	178	NUM
admet-292	335	57	134	134	NUM
admet-292	335	58	differential	differential	NOUN
admet-292	335	59	scanning	scan	VERB
admet-292	335	60	calorimetry	calorimetry	NOUN
admet-292	335	61	(	(	PUNCT
admet-292	335	62	dsc	dsc	NOUN
admet-292	335	63	)	)	PUNCT
admet-292	335	64	.	.	PUNCT
admet-292	336	1	the	the	DET
admet-292	336	2	powder	powder	NOUN
admet-292	336	3	pattern	pattern	NOUN
admet-292	336	4	for	for	ADP
admet-292	336	5	this	this	DET
admet-292	336	6	form	form	NOUN
admet-292	336	7	(	(	PUNCT
admet-292	336	8	form	form	NOUN
admet-292	336	9	i	i	PRON
admet-292	336	10	)	)	PUNCT
admet-292	336	11	matched	match	VERB
admet-292	336	12	the	the	DET
admet-292	336	13	pattern	pattern	NOUN
admet-292	336	14	reported	report	VERB
admet-292	336	15	in	in	ADP
admet-292	336	16	the	the	DET
admet-292	336	17	cambridge	cambridge	PROPN
admet-292	336	18	structural	structural	ADJ
admet-292	336	19	database	database	NOUN
admet-292	336	20	(	(	PUNCT
admet-292	336	21	csd	csd	PROPN
admet-292	336	22	reference	reference	PROPN
admet-292	336	23	code	code	PROPN
admet-292	336	24	dohrex	dohrex	PROPN
admet-292	336	25	)	)	PUNCT
admet-292	337	1	[	[	X
admet-292	337	2	75	75	NUM
admet-292	337	3	]	]	PUNCT
admet-292	337	4	.	.	PUNCT
admet-292	338	1	however	however	ADV
admet-292	338	2	,	,	PUNCT
admet-292	338	3	it	it	PRON
admet-292	338	4	was	be	AUX
admet-292	338	5	observed	observe	VERB
admet-292	338	6	that	that	SCONJ
admet-292	338	7	a	a	DET
admet-292	338	8	sudden	sudden	ADJ
admet-292	338	9	drop	drop	NOUN
admet-292	338	10	in	in	ADP
admet-292	338	11	solubility	solubility	NOUN
admet-292	338	12	from	from	ADP
admet-292	338	13	about	about	ADV
admet-292	338	14	70	70	NUM
admet-292	338	15	to	to	PART
admet-292	338	16	10	10	NUM
admet-292	338	17	μg	μg	NOUN
admet-292	338	18	/	/	SYM
admet-292	338	19	ml	ml	NOUN
admet-292	338	20	occurred	occur	VERB
admet-292	338	21	after	after	ADP
admet-292	338	22	cycling	cycle	VERB
admet-292	338	23	for	for	ADP
admet-292	338	24	20	20	PROPN
admet-292	338	25	min	min	PROPN
admet-292	338	26	(	(	PUNCT
admet-292	338	27	figures	figure	NOUN
admet-292	338	28	9	9	NUM
admet-292	338	29	and	and	CCONJ
admet-292	338	30	10	10	NUM
admet-292	338	31	)	)	PUNCT
admet-292	338	32	.	.	PUNCT
admet-292	339	1	ph	ph	PROPN
admet-292	339	2	versus	versus	ADP
admet-292	339	3	time	time	NOUN
admet-292	339	4	p	p	PROPN
admet-292	339	5	h	h	NOUN
admet-292	339	6	t	t	PROPN
admet-292	339	7	ime	ime	PROPN
admet-292	339	8	(	(	PUNCT
admet-292	339	9	minutes	minute	NOUN
admet-292	339	10	)	)	PUNCT
admet-292	339	11	5	5	NUM
admet-292	339	12	6	6	NUM
admet-292	339	13	7	7	NUM
admet-292	339	14	8	8	NUM
admet-292	339	15	9	9	NUM
admet-292	339	16	10	10	NUM
admet-292	339	17	11	11	NUM
admet-292	339	18	10	10	NUM
admet-292	339	19	20	20	NUM
admet-292	339	20	30	30	NUM
admet-292	339	21	40	40	NUM
admet-292	339	22	50	50	NUM
admet-292	339	23	figure	figure	NOUN
admet-292	339	24	10	10	NUM
admet-292	339	25	.	.	PUNCT
admet-292	340	1	evolution	evolution	NOUN
admet-292	340	2	of	of	ADP
admet-292	340	3	ph	ph	NOUN
admet-292	340	4	vs	vs	ADP
admet-292	340	5	time	time	NOUN
admet-292	340	6	for	for	ADP
admet-292	340	7	the	the	DET
admet-292	340	8	sulindac	sulindac	NOUN
admet-292	340	9	experiment	experiment	NOUN
admet-292	340	10	.	.	PUNCT
admet-292	341	1	form	form	NOUN
admet-292	341	2	i	i	PRON
admet-292	341	3	is	be	AUX
admet-292	341	4	obtained	obtain	VERB
admet-292	341	5	in	in	ADP
admet-292	341	6	pure	pure	ADJ
admet-292	341	7	form	form	NOUN
admet-292	341	8	if	if	SCONJ
admet-292	341	9	the	the	DET
admet-292	341	10	cycling	cycling	NOUN
admet-292	341	11	is	be	AUX
admet-292	341	12	stopped	stop	VERB
admet-292	341	13	before	before	ADP
admet-292	341	14	20	20	NUM
admet-292	341	15	minutes	minute	NOUN
admet-292	341	16	(	(	PUNCT
admet-292	341	17	precipitation	precipitation	NOUN
admet-292	341	18	takes	take	VERB
admet-292	341	19	place	place	NOUN
admet-292	341	20	at	at	ADP
admet-292	341	21	a	a	DET
admet-292	341	22	ph=4.5	ph=4.5	NOUN
admet-292	341	23	)	)	PUNCT
admet-292	341	24	.	.	PUNCT
admet-292	342	1	pure	pure	ADJ
admet-292	342	2	form	form	PROPN
admet-292	342	3	ii	ii	PROPN
admet-292	342	4	is	be	AUX
admet-292	342	5	obtained	obtain	VERB
admet-292	342	6	when	when	SCONJ
admet-292	342	7	the	the	DET
admet-292	342	8	cycling	cycling	NOUN
admet-292	342	9	is	be	AUX
admet-292	342	10	kept	keep	VERB
admet-292	342	11	for	for	ADP
admet-292	342	12	longer	long	ADJ
admet-292	342	13	times	time	NOUN
admet-292	342	14	(	(	PUNCT
admet-292	342	15	40	40	NUM
admet-292	342	16	-	-	SYM
admet-292	342	17	50	50	NUM
admet-292	342	18	min	min	NOUN
admet-292	342	19	,	,	PUNCT
admet-292	342	20	ph=5.7	ph=5.7	NOUN
admet-292	342	21	)	)	PUNCT
admet-292	342	22	0	0	NUM
admet-292	343	1	2000	2000	NUM
admet-292	343	2	4000	4000	NUM
admet-292	343	3	6000	6000	NUM
admet-292	343	4	8000	8000	NUM
admet-292	343	5	10000	10000	NUM
admet-292	343	6	12000	12000	NUM
admet-292	343	7	14000	14000	NUM
admet-292	343	8	16000	16000	NUM
admet-292	343	9	18000	18000	NUM
admet-292	343	10	20000	20000	NUM
admet-292	343	11	0	0	NUM
admet-292	343	12	5	5	NUM
admet-292	343	13	10	10	NUM
admet-292	343	14	15	15	NUM
admet-292	343	15	20	20	NUM
admet-292	343	16	25	25	NUM
admet-292	343	17	30	30	NUM
admet-292	343	18	35	35	NUM
admet-292	343	19	40	40	NUM
admet-292	343	20	45	45	NUM
admet-292	343	21	50	50	NUM
admet-292	343	22	c	c	NOUN
admet-292	343	23	o	o	X
admet-292	343	24	u	u	NOUN
admet-292	343	25	n	n	NOUN
admet-292	343	26	ts	ts	ADP
admet-292	343	27	2	2	NUM
admet-292	343	28	theta	theta	NOUN
admet-292	343	29	starting	start	VERB
admet-292	343	30	materialccdc	materialccdc	NOUN
admet-292	343	31	ref	ref	PROPN
admet-292	343	32	.	.	PUNCT
admet-292	344	1	dohrexmatch	dohrexmatch	PROPN
admet-292	344	2	(	(	PUNCT
admet-292	344	3	pbca	pbca	NOUN
admet-292	344	4	)	)	PUNCT
admet-292	344	5	equilibrium	equilibrium	NOUN
admet-292	344	6	precipitateno	precipitateno	NOUN
admet-292	344	7	match	match	NOUN
admet-292	344	8	/	/	SYM
admet-292	344	9	new	new	ADJ
admet-292	344	10	polymorph	polymorph	NOUN
admet-292	344	11	(	(	PUNCT
admet-292	344	12	p21	p21	NOUN
admet-292	344	13	/	/	SYM
admet-292	344	14	c	c	NOUN
admet-292	344	15	)	)	PUNCT
admet-292	344	16	first	first	ADJ
admet-292	344	17	precipitateccdc	precipitateccdc	NOUN
admet-292	344	18	ref	ref	NOUN
admet-292	344	19	.	.	PUNCT
admet-292	345	1	dohrexmatch	dohrexmatch	PROPN
admet-292	345	2	(	(	PUNCT
admet-292	345	3	pbca	pbca	ADJ
admet-292	345	4	)	)	PUNCT
admet-292	345	5	2	2	NOUN
admet-292	345	6	figure	figure	NOUN
admet-292	345	7	11	11	NUM
admet-292	345	8	powder	powder	NOUN
admet-292	345	9	x	x	NOUN
admet-292	345	10	-	-	NOUN
admet-292	345	11	ray	ray	NOUN
admet-292	345	12	diffraction	diffraction	NOUN
admet-292	345	13	of	of	ADP
admet-292	345	14	the	the	DET
admet-292	345	15	different	different	ADJ
admet-292	345	16	solid	solid	ADJ
admet-292	345	17	forms	form	NOUN
admet-292	345	18	obtained	obtain	VERB
admet-292	345	19	during	during	ADP
admet-292	345	20	the	the	DET
admet-292	345	21	sulindac	sulindac	NOUN
admet-292	345	22	[	[	X
admet-292	345	23	pc	pc	X
admet-292	345	24	]	]	X
admet-292	345	25	2	2	NUM
admet-292	345	26	experiment	experiment	NOUN
admet-292	345	27	.	.	PUNCT
admet-292	346	1	the	the	DET
admet-292	346	2	first	first	ADJ
admet-292	346	3	precipitate	precipitate	NOUN
admet-292	346	4	detected	detect	VERB
admet-292	346	5	in	in	ADP
admet-292	346	6	the	the	DET
admet-292	346	7	experiment	experiment	NOUN
admet-292	346	8	is	be	AUX
admet-292	346	9	form	form	NOUN
admet-292	346	10	i	i	PRON
admet-292	346	11	which	which	PRON
admet-292	346	12	corresponds	correspond	VERB
admet-292	346	13	to	to	ADP
admet-292	346	14	the	the	DET
admet-292	346	15	orthorhombic	orthorhombic	ADJ
admet-292	346	16	sulindac	sulindac	NOUN
admet-292	346	17	pbca	pbca	PROPN
admet-292	346	18	already	already	ADV
admet-292	346	19	described	describe	VERB
admet-292	346	20	in	in	ADP
admet-292	346	21	the	the	DET
admet-292	346	22	ccdc	ccdc	PROPN
admet-292	346	23	database	database	NOUN
admet-292	346	24	(	(	PUNCT
admet-292	346	25	dohrex	dohrex	PROPN
admet-292	346	26	)	)	PUNCT
admet-292	346	27	.	.	PUNCT
admet-292	347	1	form	form	PROPN
admet-292	347	2	ii	ii	PROPN
admet-292	347	3	did	do	AUX
admet-292	347	4	not	not	PART
admet-292	347	5	match	match	VERB
admet-292	347	6	any	any	DET
admet-292	347	7	previously	previously	ADV
admet-292	347	8	reported	report	VERB
admet-292	347	9	pattern	pattern	NOUN
admet-292	347	10	.	.	PUNCT
admet-292	348	1	the	the	DET
admet-292	348	2	new	new	ADJ
admet-292	348	3	polymorph	polymorph	NOUN
admet-292	348	4	of	of	ADP
admet-292	348	5	sulindac	sulindac	NOUN
admet-292	348	6	,	,	PUNCT
admet-292	348	7	form	form	PROPN
admet-292	348	8	ii	ii	PROPN
admet-292	348	9	,	,	PUNCT
admet-292	348	10	is	be	AUX
admet-292	348	11	the	the	DET
admet-292	348	12	most	most	ADV
admet-292	348	13	stable	stable	ADJ
admet-292	348	14	polymorph	polymorph	NOUN
admet-292	348	15	and	and	CCONJ
admet-292	348	16	corresponds	correspond	VERB
admet-292	348	17	to	to	ADP
admet-292	348	18	the	the	DET
admet-292	348	19	monoclinic	monoclinic	ADJ
admet-292	348	20	p21	p21	NOUN
admet-292	348	21	/	/	SYM
admet-292	348	22	c	c	NOUN
admet-292	348	23	form	form	NOUN
admet-292	348	24	.	.	PUNCT
admet-292	349	1	this	this	DET
admet-292	349	2	new	new	ADJ
admet-292	349	3	form	form	NOUN
admet-292	349	4	has	have	VERB
admet-292	349	5	now	now	ADV
admet-292	349	6	the	the	DET
admet-292	349	7	reference	reference	NOUN
admet-292	349	8	name	name	NOUN
admet-292	349	9	dohrex01	dohrex01	NOUN
admet-292	349	10	in	in	ADP
admet-292	349	11	the	the	DET
admet-292	349	12	ccdc	ccdc	PROPN
admet-292	349	13	database	database	NOUN
admet-292	349	14	.	.	PUNCT
admet-292	350	1	this	this	DET
admet-292	350	2	behavior	behavior	NOUN
admet-292	350	3	was	be	AUX
admet-292	350	4	repeatable	repeatable	ADJ
admet-292	350	5	and	and	CCONJ
admet-292	350	6	setting	set	VERB
admet-292	350	7	up	up	ADP
admet-292	350	8	the	the	DET
admet-292	350	9	conditions	condition	NOUN
admet-292	350	10	to	to	PART
admet-292	350	11	cycle	cycle	VERB
admet-292	350	12	for	for	ADP
admet-292	350	13	more	more	ADJ
admet-292	350	14	than	than	ADP
admet-292	350	15	20	20	NUM
admet-292	350	16	min	min	NOUN
admet-292	350	17	always	always	ADV
admet-292	350	18	produced	produce	VERB
admet-292	350	19	the	the	DET
admet-292	350	20	more	more	ADV
admet-292	350	21	stable	stable	ADJ
admet-292	350	22	form	form	NOUN
admet-292	350	23	ii	ii	NOUN
admet-292	350	24	with	with	ADP
admet-292	350	25	an	an	DET
admet-292	350	26	intrinsic	intrinsic	ADJ
admet-292	350	27	solubility	solubility	NOUN
admet-292	350	28	of	of	ADP
admet-292	350	29	10	10	NUM
admet-292	350	30	μg	μg	NOUN
admet-292	350	31	/	/	SYM
admet-292	350	32	ml	ml	PROPN
admet-292	350	33	.	.	PUNCT
admet-292	351	1	this	this	DET
admet-292	351	2	low	low	ADJ
admet-292	351	3	solubility	solubility	NOUN
admet-292	351	4	form	form	NOUN
admet-292	351	5	was	be	AUX
admet-292	351	6	isolated	isolate	VERB
admet-292	351	7	and	and	CCONJ
admet-292	351	8	characterized	characterize	VERB
admet-292	351	9	in	in	ADP
admet-292	351	10	the	the	DET
admet-292	351	11	same	same	ADJ
admet-292	351	12	manner	manner	NOUN
admet-292	351	13	as	as	ADP
admet-292	351	14	form	form	NOUN
admet-292	351	15	i	i	PRON
admet-292	351	16	but	but	CCONJ
admet-292	351	17	in	in	ADP
admet-292	351	18	this	this	DET
admet-292	351	19	case	case	NOUN
admet-292	351	20	the	the	DET
admet-292	351	21	powder	powder	NOUN
admet-292	351	22	pattern	pattern	NOUN
admet-292	351	23	did	do	AUX
admet-292	351	24	not	not	PART
admet-292	351	25	correspond	correspond	VERB
admet-292	351	26	to	to	ADP
admet-292	351	27	anything	anything	PRON
admet-292	351	28	in	in	ADP
admet-292	351	29	the	the	DET
admet-292	351	30	csd	csd	NOUN
admet-292	351	31	(	(	PUNCT
admet-292	351	32	figure	figure	NOUN
admet-292	351	33	11	11	NUM
admet-292	351	34	)	)	PUNCT
admet-292	351	35	.	.	PUNCT
admet-292	352	1	the	the	DET
admet-292	352	2	dsc	dsc	PROPN
admet-292	352	3	and	and	CCONJ
admet-292	352	4	tga	tga	PROPN
admet-292	352	5	measurements	measurement	NOUN
admet-292	352	6	confirmed	confirm	VERB
admet-292	352	7	that	that	SCONJ
admet-292	352	8	form	form	NOUN
admet-292	352	9	ii	ii	PROPN
admet-292	352	10	has	have	VERB
admet-292	352	11	no	no	DET
admet-292	352	12	solvent	solvent	NOUN
admet-292	352	13	in	in	ADP
admet-292	352	14	the	the	DET
admet-292	352	15	crystal	crystal	NOUN
admet-292	352	16	structure	structure	NOUN
admet-292	352	17	,	,	PUNCT
admet-292	352	18	and	and	CCONJ
admet-292	352	19	therefore	therefore	ADV
admet-292	352	20	it	it	PRON
admet-292	352	21	was	be	AUX
admet-292	352	22	not	not	PART
admet-292	352	23	simply	simply	ADV
admet-292	352	24	a	a	DET
admet-292	352	25	different	different	ADJ
admet-292	352	26	hydrate	hydrate	NOUN
admet-292	352	27	of	of	ADP
admet-292	352	28	sulindac	sulindac	NOUN
admet-292	352	29	.	.	PUNCT
admet-292	353	1	the	the	DET
admet-292	353	2	crystal	crystal	NOUN
admet-292	353	3	structure	structure	NOUN
admet-292	353	4	of	of	ADP
admet-292	353	5	this	this	DET
admet-292	353	6	new	new	ADJ
admet-292	353	7	form	form	NOUN
admet-292	353	8	(	(	PUNCT
admet-292	353	9	ii	ii	NOUN
admet-292	353	10	)	)	PUNCT
admet-292	353	11	was	be	AUX
admet-292	353	12	solved	solve	VERB
admet-292	353	13	from	from	ADP
admet-292	353	14	the	the	DET
admet-292	353	15	powder	powder	NOUN
admet-292	353	16	x	x	NOUN
admet-292	353	17	-	-	NOUN
admet-292	353	18	ray	ray	NOUN
admet-292	353	19	diffraction	diffraction	NOUN
admet-292	353	20	pattern	pattern	NOUN
admet-292	353	21	using	use	VERB
admet-292	353	22	the	the	DET
admet-292	353	23	simulated	simulated	ADJ
admet-292	353	24	annealing	anneal	VERB
admet-292	353	25	algorithm	algorithm	NOUN
admet-292	353	26	implemented	implement	VERB
admet-292	353	27	in	in	ADP
admet-292	353	28	dash	dash	NOUN
admet-292	353	29	[	[	X
admet-292	353	30	76	76	NUM
admet-292	353	31	]	]	PUNCT
admet-292	353	32	,	,	PUNCT
admet-292	353	33	and	and	CCONJ
admet-292	353	34	refined	refined	ADJ
admet-292	353	35	using	use	VERB
admet-292	353	36	the	the	DET
admet-292	353	37	rietveld	rietveld	NOUN
admet-292	353	38	method	method	NOUN
admet-292	353	39	implemented	implement	VERB
admet-292	353	40	in	in	ADP
admet-292	353	41	the	the	DET
admet-292	353	42	general	general	ADJ
admet-292	353	43	structure	structure	NOUN
admet-292	353	44	analysis	analysis	NOUN
admet-292	353	45	system	system	NOUN
admet-292	353	46	[	[	X
admet-292	353	47	77	77	NUM
admet-292	353	48	]	]	PUNCT
admet-292	353	49	.	.	PUNCT
admet-292	354	1	the	the	DET
admet-292	354	2	factor	factor	NOUN
admet-292	354	3	of	of	ADP
admet-292	354	4	seven	seven	NUM
admet-292	354	5	fold	fold	NOUN
admet-292	354	6	between	between	ADP
admet-292	354	7	the	the	DET
admet-292	354	8	intrinsic	intrinsic	ADJ
admet-292	354	9	solubility	solubility	NOUN
admet-292	354	10	of	of	ADP
admet-292	354	11	the	the	DET
admet-292	354	12	original	original	ADJ
admet-292	354	13	form	form	NOUN
admet-292	354	14	i	i	PRON
admet-292	354	15	of	of	ADP
admet-292	354	16	sulindac	sulindac	PROPN
admet-292	354	17	admet	admet	PROPN
admet-292	354	18	&	&	CCONJ
admet-292	354	19	dmpk	dmpk	PROPN
admet-292	354	20	4(2	4(2	NUM
admet-292	354	21	)	)	PUNCT
admet-292	354	22	(	(	PUNCT
admet-292	354	23	2016	2016	NUM
admet-292	354	24	)	)	PUNCT
admet-292	354	25	117	117	NUM
admet-292	354	26	-	-	SYM
admet-292	354	27	178	178	NUM
admet-292	354	28	consensus	consensus	NOUN
admet-292	354	29	recommendations	recommendation	NOUN
admet-292	354	30	for	for	ADP
admet-292	354	31	improving	improve	VERB
admet-292	354	32	solubility	solubility	NOUN
admet-292	354	33	-	-	PUNCT
admet-292	354	34	ph	ph	ADJ
admet-292	354	35	data	datum	NOUN
admet-292	354	36	quality	quality	NOUN
admet-292	354	37	doi	doi	NOUN
admet-292	354	38	:	:	PUNCT
admet-292	354	39	10.5599	10.5599	NUM
admet-292	354	40	/	/	SYM
admet-292	354	41	admet.4.2.292	admet.4.2.292	DET
admet-292	354	42	135	135	NUM
admet-292	354	43	and	and	CCONJ
admet-292	354	44	this	this	DET
admet-292	354	45	new	new	ADJ
admet-292	354	46	more	more	ADV
admet-292	354	47	stable	stable	ADJ
admet-292	354	48	form	form	NOUN
admet-292	354	49	ii	ii	NOUN
admet-292	354	50	is	be	AUX
admet-292	354	51	unusually	unusually	ADV
admet-292	354	52	large	large	ADJ
admet-292	354	53	,	,	PUNCT
admet-292	354	54	but	but	CCONJ
admet-292	354	55	based	base	VERB
admet-292	354	56	on	on	ADP
admet-292	354	57	many	many	ADJ
admet-292	354	58	other	other	ADJ
admet-292	354	59	[	[	X
admet-292	354	60	pc	pc	X
admet-292	354	61	]	]	SYM
admet-292	354	62	2	2	NUM
admet-292	354	63	experiments	experiment	NOUN
admet-292	354	64	performed	perform	VERB
admet-292	354	65	on	on	ADP
admet-292	354	66	different	different	ADJ
admet-292	354	67	materials	material	NOUN
admet-292	354	68	,	,	PUNCT
admet-292	354	69	a	a	DET
admet-292	354	70	10	10	NUM
admet-292	354	71	fold	fold	ADJ
admet-292	354	72	difference	difference	NOUN
admet-292	354	73	is	be	AUX
admet-292	354	74	quite	quite	ADV
admet-292	354	75	common	common	ADJ
admet-292	354	76	.	.	PUNCT
admet-292	355	1	the	the	DET
admet-292	355	2	[	[	X
admet-292	355	3	pc	pc	NOUN
admet-292	355	4	]	]	SYM
admet-292	355	5	2	2	NUM
admet-292	355	6	approach	approach	NOUN
admet-292	355	7	is	be	AUX
admet-292	355	8	therefore	therefore	ADV
admet-292	355	9	a	a	DET
admet-292	355	10	very	very	ADV
admet-292	355	11	promising	promising	ADJ
admet-292	355	12	technique	technique	NOUN
admet-292	355	13	to	to	PART
admet-292	355	14	measure	measure	VERB
admet-292	355	15	accurately	accurately	ADV
admet-292	355	16	and	and	CCONJ
admet-292	355	17	reproducibly	reproducibly	ADV
admet-292	355	18	the	the	DET
admet-292	355	19	intrinsic	intrinsic	ADJ
admet-292	355	20	solubility	solubility	NOUN
admet-292	355	21	of	of	ADP
admet-292	355	22	different	different	ADJ
admet-292	355	23	polymorphs	polymorph	NOUN
admet-292	355	24	,	,	PUNCT
admet-292	355	25	since	since	SCONJ
admet-292	355	26	the	the	DET
admet-292	355	27	approach	approach	NOUN
admet-292	355	28	is	be	AUX
admet-292	355	29	able	able	ADJ
admet-292	355	30	to	to	PART
admet-292	355	31	generate	generate	VERB
admet-292	355	32	metastable	metastable	ADJ
admet-292	355	33	and	and	CCONJ
admet-292	355	34	stable	stable	ADJ
admet-292	355	35	polymorphs	polymorph	NOUN
admet-292	355	36	.	.	PUNCT
admet-292	356	1	experiment	experiment	NOUN
admet-292	356	2	to	to	PART
admet-292	356	3	produce	produce	VERB
admet-292	356	4	the	the	DET
admet-292	356	5	hydrate	hydrate	NOUN
admet-292	356	6	or	or	CCONJ
admet-292	356	7	the	the	DET
admet-292	356	8	anhydrous	anhydrous	ADJ
admet-292	356	9	form	form	NOUN
admet-292	356	10	exclusively	exclusively	ADV
admet-292	356	11	(	(	PUNCT
admet-292	356	12	when	when	SCONJ
admet-292	356	13	possible	possible	ADJ
admet-292	356	14	)	)	PUNCT
admet-292	356	15	can	can	AUX
admet-292	356	16	be	be	AUX
admet-292	356	17	designed	design	VERB
admet-292	356	18	.	.	PUNCT
admet-292	357	1	the	the	DET
admet-292	357	2	application	application	NOUN
admet-292	357	3	of	of	ADP
admet-292	357	4	the	the	DET
admet-292	357	5	[	[	X
admet-292	357	6	pc	pc	NOUN
admet-292	357	7	]	]	SYM
admet-292	357	8	2	2	NUM
admet-292	357	9	technique	technique	NOUN
admet-292	357	10	to	to	ADP
admet-292	357	11	polymorphic	polymorphic	ADJ
admet-292	357	12	systems	system	NOUN
admet-292	357	13	apparently	apparently	ADV
admet-292	357	14	generates	generate	VERB
admet-292	357	15	the	the	DET
admet-292	357	16	most	most	ADV
admet-292	357	17	stable	stable	ADJ
admet-292	357	18	form	form	NOUN
admet-292	357	19	of	of	ADP
admet-292	357	20	the	the	DET
admet-292	357	21	compound	compound	NOUN
admet-292	357	22	,	,	PUNCT
admet-292	357	23	which	which	PRON
admet-292	357	24	is	be	AUX
admet-292	357	25	especially	especially	ADV
admet-292	357	26	appealing	appeal	VERB
admet-292	357	27	to	to	ADP
admet-292	357	28	the	the	DET
admet-292	357	29	pharmaceutical	pharmaceutical	ADJ
admet-292	357	30	industry	industry	NOUN
admet-292	357	31	.	.	PUNCT
admet-292	358	1	by	by	ADP
admet-292	358	2	controlling	control	VERB
admet-292	358	3	the	the	DET
admet-292	358	4	experimental	experimental	ADJ
admet-292	358	5	conditions	condition	NOUN
admet-292	358	6	,	,	PUNCT
admet-292	358	7	also	also	ADV
admet-292	358	8	metastable	metastable	ADJ
admet-292	358	9	forms	form	NOUN
admet-292	358	10	can	can	AUX
admet-292	358	11	be	be	AUX
admet-292	358	12	obtained	obtain	VERB
admet-292	358	13	on	on	ADP
admet-292	358	14	purpose	purpose	NOUN
admet-292	358	15	.	.	PUNCT
admet-292	359	1	solid	solid	ADJ
admet-292	359	2	state	state	NOUN
admet-292	359	3	characterization	characterization	NOUN
admet-292	359	4	,	,	PUNCT
admet-292	359	5	polymorphs	polymorph	NOUN
admet-292	359	6	,	,	PUNCT
admet-292	359	7	hydrates	hydrate	NOUN
admet-292	359	8	,	,	PUNCT
admet-292	359	9	cocrystals	cocrystal	VERB
admet-292	359	10	analysis	analysis	NOUN
admet-292	359	11	not	not	PART
admet-292	359	12	only	only	ADV
admet-292	359	13	of	of	ADP
admet-292	359	14	the	the	DET
admet-292	359	15	solution	solution	NOUN
admet-292	359	16	,	,	PUNCT
admet-292	359	17	but	but	CCONJ
admet-292	359	18	also	also	ADV
admet-292	359	19	of	of	ADP
admet-292	359	20	the	the	DET
admet-292	359	21	solid	solid	ADJ
admet-292	359	22	residue	residue	NOUN
admet-292	359	23	,	,	PUNCT
admet-292	359	24	at	at	ADP
admet-292	359	25	least	least	ADJ
admet-292	359	26	at	at	ADP
admet-292	359	27	the	the	DET
admet-292	359	28	beginning	beginning	NOUN
admet-292	359	29	and	and	CCONJ
admet-292	359	30	at	at	ADP
admet-292	359	31	the	the	DET
admet-292	359	32	end	end	NOUN
admet-292	359	33	of	of	ADP
admet-292	359	34	a	a	DET
admet-292	359	35	dissolution	dissolution	ADJ
admet-292	359	36	experiment	experiment	NOUN
admet-292	359	37	,	,	PUNCT
admet-292	359	38	is	be	AUX
admet-292	359	39	often	often	ADV
admet-292	359	40	claimed	claim	VERB
admet-292	359	41	to	to	PART
admet-292	359	42	be	be	AUX
admet-292	359	43	too	too	ADV
admet-292	359	44	time	time	NOUN
admet-292	359	45	-	-	PUNCT
admet-292	359	46	consuming	consume	VERB
admet-292	359	47	,	,	PUNCT
admet-292	359	48	to	to	PART
admet-292	359	49	be	be	AUX
admet-292	359	50	recommended	recommend	VERB
admet-292	359	51	for	for	ADP
admet-292	359	52	common	common	ADJ
admet-292	359	53	use	use	NOUN
admet-292	359	54	.	.	PUNCT
admet-292	360	1	however	however	ADV
admet-292	360	2	,	,	PUNCT
admet-292	360	3	the	the	DET
admet-292	360	4	interpretation	interpretation	NOUN
admet-292	360	5	of	of	ADP
admet-292	360	6	the	the	DET
admet-292	360	7	results	result	NOUN
admet-292	360	8	of	of	ADP
admet-292	360	9	a	a	DET
admet-292	360	10	dissolution	dissolution	NOUN
admet-292	360	11	measurement	measurement	NOUN
admet-292	360	12	can	can	AUX
admet-292	360	13	be	be	AUX
admet-292	360	14	misleading	misleading	ADJ
admet-292	360	15	,	,	PUNCT
admet-292	360	16	if	if	SCONJ
admet-292	360	17	solubility	solubility	NOUN
admet-292	360	18	refers	refer	VERB
admet-292	360	19	to	to	ADP
admet-292	360	20	the	the	DET
admet-292	360	21	wrong	wrong	NOUN
admet-292	360	22	(	(	PUNCT
admet-292	360	23	or	or	CCONJ
admet-292	360	24	unknown	unknown	ADJ
admet-292	360	25	)	)	PUNCT
admet-292	360	26	solid	solid	ADJ
admet-292	360	27	phase	phase	NOUN
admet-292	360	28	.	.	PUNCT
admet-292	361	1	modern	modern	ADJ
admet-292	361	2	powder	powder	NOUN
admet-292	361	3	x	x	NOUN
admet-292	361	4	-	-	NOUN
admet-292	361	5	ray	ray	NOUN
admet-292	361	6	diffraction	diffraction	NOUN
admet-292	361	7	(	(	PUNCT
admet-292	361	8	pxrd	pxrd	NOUN
admet-292	361	9	)	)	PUNCT
admet-292	361	10	techniques	technique	NOUN
admet-292	361	11	make	make	VERB
admet-292	361	12	it	it	PRON
admet-292	361	13	possible	possible	ADJ
admet-292	361	14	to	to	PART
admet-292	361	15	follow	follow	VERB
admet-292	361	16	the	the	DET
admet-292	361	17	composition	composition	NOUN
admet-292	361	18	of	of	ADP
admet-292	361	19	a	a	DET
admet-292	361	20	solid	solid	ADJ
admet-292	361	21	phase	phase	NOUN
admet-292	361	22	directly	directly	ADV
admet-292	361	23	in	in	ADP
admet-292	361	24	solution	solution	NOUN
admet-292	361	25	in	in	ADP
admet-292	361	26	situ	situ	NOUN
admet-292	361	27	,	,	PUNCT
admet-292	361	28	and	and	CCONJ
admet-292	361	29	also	also	ADV
admet-292	361	30	in	in	ADP
admet-292	361	31	high	high	ADJ
admet-292	361	32	-	-	PUNCT
admet-292	361	33	throughput	throughput	NOUN
admet-292	361	34	screening	screen	VERB
admet-292	361	35	experiments	experiment	NOUN
admet-292	361	36	(	(	PUNCT
admet-292	361	37	e.g.	e.g.	ADV
admet-292	361	38	,	,	PUNCT
admet-292	361	39	using	use	VERB
admet-292	361	40	instruments	instrument	NOUN
admet-292	361	41	from	from	ADP
admet-292	361	42	panalytical	panalytical	ADJ
admet-292	361	43	[	[	X
admet-292	361	44	78	78	NUM
admet-292	361	45	]	]	PUNCT
admet-292	361	46	,	,	PUNCT
admet-292	361	47	or	or	CCONJ
admet-292	361	48	bruker	bruker	VERB
admet-292	361	49	[	[	X
admet-292	361	50	79	79	NUM
admet-292	361	51	]	]	PUNCT
admet-292	361	52	)	)	PUNCT
admet-292	361	53	.	.	PUNCT
admet-292	362	1	when	when	SCONJ
admet-292	362	2	characterizing	characterize	VERB
admet-292	362	3	a	a	DET
admet-292	362	4	solid	solid	ADJ
admet-292	362	5	sample	sample	NOUN
admet-292	362	6	by	by	ADP
admet-292	362	7	pxrd	pxrd	NOUN
admet-292	362	8	,	,	PUNCT
admet-292	362	9	it	it	PRON
admet-292	362	10	is	be	AUX
admet-292	362	11	important	important	ADJ
admet-292	362	12	not	not	PART
admet-292	362	13	to	to	PART
admet-292	362	14	limit	limit	VERB
admet-292	362	15	the	the	DET
admet-292	362	16	analysis	analysis	NOUN
admet-292	362	17	by	by	ADP
admet-292	362	18	considering	consider	VERB
admet-292	362	19	one	one	NUM
admet-292	362	20	or	or	CCONJ
admet-292	362	21	two	two	NUM
admet-292	362	22	characteristic	characteristic	ADJ
admet-292	362	23	peaks	peak	NOUN
admet-292	362	24	,	,	PUNCT
admet-292	362	25	but	but	CCONJ
admet-292	362	26	to	to	PART
admet-292	362	27	analyze	analyze	VERB
admet-292	362	28	the	the	DET
admet-292	362	29	whole	whole	ADJ
admet-292	362	30	diffraction	diffraction	NOUN
admet-292	362	31	pattern	pattern	NOUN
admet-292	362	32	.	.	PUNCT
admet-292	363	1	diffraction	diffraction	NOUN
admet-292	363	2	patterns	pattern	NOUN
admet-292	363	3	of	of	ADP
admet-292	363	4	some	some	DET
admet-292	363	5	polymorphs	polymorph	NOUN
admet-292	363	6	can	can	AUX
admet-292	363	7	be	be	AUX
admet-292	363	8	very	very	ADV
admet-292	363	9	similar	similar	ADJ
admet-292	363	10	at	at	ADP
admet-292	363	11	low	low	ADJ
admet-292	363	12	values	value	NOUN
admet-292	363	13	of	of	ADP
admet-292	363	14	2	2	NUM
admet-292	363	15	diffraction	diffraction	NOUN
admet-292	363	16	angles	angle	NOUN
admet-292	363	17	,	,	PUNCT
admet-292	363	18	so	so	SCONJ
admet-292	363	19	that	that	SCONJ
admet-292	363	20	they	they	PRON
admet-292	363	21	can	can	AUX
admet-292	363	22	be	be	AUX
admet-292	363	23	distinguished	distinguish	VERB
admet-292	363	24	only	only	ADV
admet-292	363	25	if	if	SCONJ
admet-292	363	26	data	datum	NOUN
admet-292	363	27	are	be	AUX
admet-292	363	28	collected	collect	VERB
admet-292	363	29	also	also	ADV
admet-292	363	30	at	at	ADP
admet-292	363	31	higher	high	ADJ
admet-292	363	32	angles	angle	NOUN
admet-292	363	33	(	(	PUNCT
admet-292	363	34	see	see	VERB
admet-292	363	35	as	as	ADP
admet-292	363	36	an	an	DET
admet-292	363	37	example	example	NOUN
admet-292	363	38	diffraction	diffraction	NOUN
admet-292	363	39	patterns	pattern	NOUN
admet-292	363	40	of	of	ADP
admet-292	363	41	the	the	DET
admet-292	363	42	α	α	PROPN
admet-292	363	43	,	,	PUNCT
admet-292	363	44	ε	ε	PROPN
admet-292	363	45	,	,	PUNCT
admet-292	363	46	ε’-polymorphs	ε’-polymorph	NOUN
admet-292	363	47	of	of	ADP
admet-292	363	48	chlorpropamide	chlorpropamide	NOUN
admet-292	363	49	,	,	PUNCT
admet-292	363	50	figure	figure	VERB
admet-292	363	51	12	12	NUM
admet-292	364	1	[	[	X
admet-292	364	2	80	80	NUM
admet-292	364	3	]	]	PUNCT
admet-292	364	4	)	)	PUNCT
admet-292	364	5	.	.	PUNCT
admet-292	365	1	one	one	PRON
admet-292	365	2	can	can	AUX
admet-292	365	3	also	also	ADV
admet-292	365	4	use	use	VERB
admet-292	365	5	confocal	confocal	ADJ
admet-292	365	6	raman	raman	NOUN
admet-292	365	7	spectroscopy	spectroscopy	NOUN
admet-292	365	8	for	for	ADP
admet-292	365	9	fast	fast	ADJ
admet-292	365	10	analysis	analysis	NOUN
admet-292	365	11	of	of	ADP
admet-292	365	12	the	the	DET
admet-292	365	13	solid	solid	ADJ
admet-292	365	14	phase	phase	NOUN
admet-292	365	15	[	[	X
admet-292	365	16	81	81	NUM
admet-292	365	17	,	,	PUNCT
admet-292	365	18	82	82	NUM
admet-292	365	19	]	]	PUNCT
admet-292	365	20	,	,	PUNCT
admet-292	365	21	although	although	SCONJ
admet-292	365	22	raman	raman	NOUN
admet-292	365	23	spectroscopy	spectroscopy	NOUN
admet-292	365	24	may	may	AUX
admet-292	365	25	be	be	AUX
admet-292	365	26	less	less	ADV
admet-292	365	27	sensitive	sensitive	ADJ
admet-292	365	28	for	for	ADP
admet-292	365	29	distinguishing	distinguish	VERB
admet-292	365	30	between	between	ADP
admet-292	365	31	the	the	DET
admet-292	365	32	polymorphs	polymorph	NOUN
admet-292	365	33	with	with	ADP
admet-292	365	34	common	common	ADJ
admet-292	365	35	structural	structural	ADJ
admet-292	365	36	motifs	motif	NOUN
admet-292	365	37	than	than	SCONJ
admet-292	365	38	pxrd	pxrd	NOUN
admet-292	365	39	is	be	AUX
admet-292	365	40	.	.	PUNCT
admet-292	366	1	it	it	PRON
admet-292	366	2	is	be	AUX
admet-292	366	3	also	also	ADV
admet-292	366	4	very	very	ADV
admet-292	366	5	instructive	instructive	ADJ
admet-292	366	6	to	to	PART
admet-292	366	7	monitor	monitor	VERB
admet-292	366	8	a	a	DET
admet-292	366	9	crystal	crystal	NOUN
admet-292	366	10	of	of	ADP
admet-292	366	11	a	a	DET
admet-292	366	12	selected	select	VERB
admet-292	366	13	original	original	ADJ
admet-292	366	14	phase	phase	NOUN
admet-292	366	15	directly	directly	ADV
admet-292	366	16	in	in	ADP
admet-292	366	17	solution	solution	NOUN
admet-292	366	18	using	use	VERB
admet-292	366	19	an	an	DET
admet-292	366	20	optical	optical	ADJ
admet-292	366	21	microscope	microscope	NOUN
admet-292	366	22	:	:	PUNCT
admet-292	366	23	quite	quite	ADV
admet-292	366	24	often	often	ADV
admet-292	366	25	a	a	DET
admet-292	366	26	recrystallization	recrystallization	NOUN
admet-292	366	27	into	into	ADP
admet-292	366	28	another	another	DET
admet-292	366	29	solid	solid	ADJ
admet-292	366	30	phase	phase	NOUN
admet-292	366	31	can	can	AUX
admet-292	366	32	be	be	AUX
admet-292	366	33	visually	visually	ADV
admet-292	366	34	evident	evident	ADJ
admet-292	366	35	(	(	PUNCT
admet-292	366	36	see	see	VERB
admet-292	366	37	figure	figure	NOUN
admet-292	366	38	13	13	NUM
admet-292	366	39	as	as	ADP
admet-292	366	40	an	an	DET
admet-292	366	41	example	example	NOUN
admet-292	366	42	)	)	PUNCT
admet-292	366	43	,	,	PUNCT
admet-292	366	44	but	but	CCONJ
admet-292	366	45	that	that	PRON
admet-292	366	46	should	should	AUX
admet-292	366	47	never	never	ADV
admet-292	366	48	be	be	AUX
admet-292	366	49	taken	take	VERB
admet-292	366	50	as	as	ADP
admet-292	366	51	proof	proof	NOUN
admet-292	366	52	of	of	ADP
admet-292	366	53	different	different	ADJ
admet-292	366	54	polymorphs	polymorph	NOUN
admet-292	366	55	since	since	SCONJ
admet-292	366	56	a	a	DET
admet-292	366	57	single	single	ADJ
admet-292	366	58	form	form	NOUN
admet-292	366	59	can	can	AUX
admet-292	366	60	show	show	VERB
admet-292	366	61	multiple	multiple	ADJ
admet-292	366	62	morphologies	morphology	NOUN
admet-292	366	63	.	.	PUNCT
admet-292	367	1	the	the	DET
admet-292	367	2	following	follow	VERB
admet-292	367	3	example	example	NOUN
admet-292	367	4	further	far	ADV
admet-292	367	5	illustrates	illustrate	VERB
admet-292	367	6	some	some	PRON
admet-292	367	7	of	of	ADP
admet-292	367	8	the	the	DET
admet-292	367	9	kinds	kind	NOUN
admet-292	367	10	of	of	ADP
admet-292	367	11	unexpected	unexpected	ADJ
admet-292	367	12	results	result	NOUN
admet-292	367	13	that	that	PRON
admet-292	367	14	may	may	AUX
admet-292	367	15	arise	arise	VERB
admet-292	367	16	following	follow	VERB
admet-292	367	17	solid	solid	ADJ
admet-292	367	18	-	-	PUNCT
admet-292	367	19	state	state	NOUN
admet-292	367	20	characterization	characterization	NOUN
admet-292	367	21	,	,	PUNCT
admet-292	367	22	which	which	PRON
admet-292	367	23	might	might	AUX
admet-292	367	24	surprise	surprise	VERB
admet-292	367	25	some	some	DET
admet-292	367	26	practitioners	practitioner	NOUN
admet-292	367	27	.	.	PUNCT
admet-292	368	1	the	the	DET
admet-292	368	2	differential	differential	NOUN
admet-292	368	3	scanning	scan	VERB
admet-292	368	4	calorimetry	calorimetry	NOUN
admet-292	368	5	(	(	PUNCT
admet-292	368	6	dsc	dsc	NOUN
admet-292	368	7	)	)	PUNCT
admet-292	368	8	of	of	ADP
admet-292	368	9	a	a	DET
admet-292	368	10	hydrochloride	hydrochloride	NOUN
admet-292	368	11	salt	salt	NOUN
admet-292	368	12	of	of	ADP
admet-292	368	13	an	an	DET
admet-292	368	14	insoluble	insoluble	ADJ
admet-292	368	15	base	base	NOUN
admet-292	368	16	(	(	PUNCT
admet-292	368	17	pka	pka	PROPN
admet-292	368	18			NOUN
admet-292	368	19	9	9	NUM
admet-292	368	20	)	)	PUNCT
admet-292	368	21	indicated	indicate	VERB
admet-292	368	22	a	a	DET
admet-292	368	23	sharp	sharp	ADJ
admet-292	368	24	negative	negative	ADJ
admet-292	368	25	peak	peak	NOUN
admet-292	368	26	,	,	PUNCT
admet-292	368	27	corresponding	correspond	VERB
admet-292	368	28	to	to	ADP
admet-292	368	29	the	the	DET
admet-292	368	30	melting	melting	NOUN
admet-292	368	31	point	point	NOUN
admet-292	368	32	of	of	ADP
admet-292	368	33	the	the	DET
admet-292	368	34	drug	drug	NOUN
admet-292	368	35	salt	salt	NOUN
admet-292	368	36	.	.	PUNCT
admet-292	369	1	the	the	DET
admet-292	369	2	salt	salt	NOUN
admet-292	369	3	was	be	AUX
admet-292	369	4	added	add	VERB
admet-292	369	5	in	in	ADP
admet-292	369	6	substantial	substantial	ADJ
admet-292	369	7	excess	excess	NOUN
admet-292	369	8	to	to	ADP
admet-292	369	9	a	a	DET
admet-292	369	10	neutral	neutral	ADJ
admet-292	369	11	solution	solution	NOUN
admet-292	369	12	(	(	PUNCT
admet-292	369	13	where	where	SCONJ
admet-292	369	14	not	not	PART
admet-292	369	15	the	the	DET
admet-292	369	16	entire	entire	ADJ
admet-292	369	17	solid	solid	ADJ
admet-292	369	18	dissolved	dissolve	VERB
admet-292	369	19	)	)	PUNCT
admet-292	369	20	,	,	PUNCT
admet-292	369	21	whose	whose	DET
admet-292	369	22	ph	ph	NOUN
admet-292	369	23	was	be	AUX
admet-292	369	24	subsequently	subsequently	ADV
admet-292	369	25	adjusted	adjust	VERB
admet-292	369	26	to	to	ADP
admet-292	369	27	10	10	NUM
admet-292	369	28	.	.	PUNCT
admet-292	370	1	after	after	ADP
admet-292	370	2	24	24	NUM
admet-292	370	3	h	h	NOUN
admet-292	370	4	,	,	PUNCT
admet-292	370	5	the	the	DET
admet-292	370	6	solid	solid	ADJ
admet-292	370	7	was	be	AUX
admet-292	370	8	filtered	filter	VERB
admet-292	370	9	out	out	ADP
admet-292	370	10	,	,	PUNCT
admet-292	370	11	rinsed	rinse	VERB
admet-292	370	12	and	and	CCONJ
admet-292	370	13	dried	dry	VERB
admet-292	370	14	,	,	PUNCT
admet-292	370	15	and	and	CCONJ
admet-292	370	16	had	have	VERB
admet-292	370	17	its	its	PRON
admet-292	370	18	dsc	dsc	NOUN
admet-292	370	19	run	run	NOUN
admet-292	370	20	.	.	PUNCT
admet-292	371	1	a	a	DET
admet-292	371	2	much	much	ADV
admet-292	371	3	lower	low	ADJ
admet-292	371	4	melting	melting	NOUN
admet-292	371	5	point	point	NOUN
admet-292	371	6	corresponding	correspond	VERB
admet-292	371	7	to	to	ADP
admet-292	371	8	the	the	DET
admet-292	371	9	free	free	ADJ
admet-292	371	10	base	base	NOUN
admet-292	371	11	was	be	AUX
admet-292	371	12	expected	expect	VERB
admet-292	371	13	.	.	PUNCT
admet-292	372	1	however	however	ADV
admet-292	372	2	,	,	PUNCT
admet-292	372	3	the	the	DET
admet-292	372	4	melting	melting	NOUN
admet-292	372	5	point	point	NOUN
admet-292	372	6	actually	actually	ADV
admet-292	372	7	measured	measure	VERB
admet-292	372	8	by	by	ADP
admet-292	372	9	dsc	dsc	PROPN
admet-292	372	10	was	be	AUX
admet-292	372	11	identical	identical	ADJ
admet-292	372	12	to	to	ADP
admet-292	372	13	the	the	DET
admet-292	372	14	original	original	ADJ
admet-292	372	15	drug	drug	NOUN
admet-292	372	16	salt	salt	NOUN
admet-292	372	17	starting	start	VERB
admet-292	372	18	material	material	NOUN
admet-292	372	19	.	.	PUNCT
admet-292	373	1	a	a	DET
admet-292	373	2	possible	possible	ADJ
admet-292	373	3	explanation	explanation	NOUN
admet-292	373	4	is	be	AUX
admet-292	373	5	as	as	SCONJ
admet-292	373	6	follows	follow	VERB
admet-292	373	7	.	.	PUNCT
admet-292	374	1	when	when	SCONJ
admet-292	374	2	a	a	DET
admet-292	374	3	practically	practically	ADV
admet-292	374	4	insoluble	insoluble	ADJ
admet-292	374	5	base	base	NOUN
admet-292	374	6	(	(	PUNCT
admet-292	374	7	e.g.	e.g.	ADV
admet-292	374	8	,	,	PUNCT
admet-292	374	9	thioridazine	thioridazine	PROPN
admet-292	374	10	)	)	PUNCT
admet-292	374	11	is	be	AUX
admet-292	374	12	added	add	VERB
admet-292	374	13	as	as	ADP
admet-292	374	14	a	a	DET
admet-292	374	15	hydrochloride	hydrochloride	NOUN
admet-292	374	16	salt	salt	NOUN
admet-292	374	17	in	in	ADP
admet-292	374	18	large	large	ADJ
admet-292	374	19	excess	excess	NOUN
admet-292	374	20	to	to	ADP
admet-292	374	21	a	a	DET
admet-292	374	22	neutral	neutral	ADJ
admet-292	374	23	solution	solution	NOUN
admet-292	374	24	,	,	PUNCT
admet-292	374	25	and	and	CCONJ
admet-292	374	26	the	the	DET
admet-292	374	27	resultant	resultant	NOUN
admet-292	374	28	suspension	suspension	NOUN
admet-292	374	29	is	be	AUX
admet-292	374	30	then	then	ADV
admet-292	374	31	quickly	quickly	ADV
admet-292	374	32	made	make	VERB
admet-292	374	33	alkaline	alkaline	NOUN
admet-292	374	34	(	(	PUNCT
admet-292	374	35	ph	ph	ADJ
admet-292	374	36	>	>	X
admet-292	374	37	pka	pka	PROPN
admet-292	374	38	)	)	PUNCT
admet-292	374	39	,	,	PUNCT
admet-292	374	40	it	it	PRON
admet-292	374	41	is	be	AUX
admet-292	374	42	possible	possible	ADJ
admet-292	374	43	that	that	SCONJ
admet-292	374	44	the	the	DET
admet-292	374	45	drug	drug	NOUN
admet-292	374	46	released	release	VERB
admet-292	374	47	from	from	ADP
admet-292	374	48	the	the	DET
admet-292	374	49	dissolving	dissolve	VERB
admet-292	374	50	salt	salt	NOUN
admet-292	374	51	particles	particle	NOUN
admet-292	374	52	immediately	immediately	ADV
admet-292	374	53	reprecipitates	reprecipitate	VERB
admet-292	374	54	as	as	ADP
admet-292	374	55	the	the	DET
admet-292	374	56	free	free	ADJ
admet-292	374	57	base	base	NOUN
admet-292	374	58	on	on	ADP
admet-292	374	59	the	the	DET
admet-292	374	60	surface	surface	NOUN
admet-292	374	61	of	of	ADP
admet-292	374	62	the	the	DET
admet-292	374	63	salt	salt	NOUN
admet-292	374	64	particles	particle	NOUN
admet-292	374	65	,	,	PUNCT
admet-292	374	66	quickly	quickly	ADV
admet-292	374	67	encasing	encase	VERB
admet-292	374	68	them	they	PRON
admet-292	374	69	.	.	PUNCT
admet-292	375	1	these	these	DET
admet-292	375	2	free	free	ADJ
admet-292	375	3	-	-	PUNCT
admet-292	375	4	base	base	NOUN
admet-292	375	5	coated	coated	ADJ
admet-292	375	6	particles	particle	NOUN
admet-292	375	7	of	of	ADP
admet-292	375	8	undissolved	undissolved	ADJ
admet-292	375	9	salt	salt	NOUN
admet-292	375	10	can	can	AUX
admet-292	375	11	be	be	AUX
admet-292	375	12	stable	stable	ADJ
admet-292	375	13	in	in	ADP
admet-292	375	14	solution	solution	NOUN
admet-292	375	15	.	.	PUNCT
admet-292	376	1	the	the	DET
admet-292	376	2	suspension	suspension	NOUN
admet-292	376	3	may	may	AUX
admet-292	376	4	reach	reach	VERB
admet-292	376	5	a	a	DET
admet-292	376	6	steady	steady	ADJ
admet-292	376	7	state	state	NOUN
admet-292	376	8	after	after	ADP
admet-292	376	9	24	24	NUM
admet-292	376	10	h	h	NOUN
admet-292	376	11	,	,	PUNCT
admet-292	376	12	regulated	regulate	VERB
admet-292	376	13	by	by	ADP
admet-292	376	14	the	the	DET
admet-292	376	15	surface	surface	NOUN
admet-292	376	16	coating	coating	NOUN
admet-292	376	17	(	(	PUNCT
admet-292	376	18	which	which	PRON
admet-292	376	19	may	may	AUX
admet-292	376	20	be	be	AUX
admet-292	376	21	amorphous	amorphous	ADJ
admet-292	376	22	,	,	PUNCT
admet-292	376	23	or	or	CCONJ
admet-292	376	24	crystalline	crystalline	NOUN
admet-292	376	25	,	,	PUNCT
admet-292	376	26	or	or	CCONJ
admet-292	376	27	oil	oil	NOUN
admet-292	376	28	)	)	PUNCT
admet-292	376	29	of	of	ADP
admet-292	376	30	the	the	DET
admet-292	376	31	practically	practically	ADV
admet-292	376	32	-	-	PUNCT
admet-292	376	33	insoluble	insoluble	ADJ
admet-292	376	34	free	free	ADJ
admet-292	376	35	base	base	NOUN
admet-292	376	36	,	,	PUNCT
admet-292	376	37	although	although	SCONJ
admet-292	376	38	the	the	DET
admet-292	376	39	suspension	suspension	NOUN
admet-292	376	40	contains	contain	VERB
admet-292	376	41	considerable	considerable	ADJ
admet-292	376	42	undissolved	undissolved	ADJ
admet-292	376	43	crystalline	crystalline	NOUN
admet-292	376	44	salt	salt	NOUN
admet-292	376	45	,	,	PUNCT
admet-292	376	46	insulated	insulate	VERB
admet-292	376	47	from	from	ADP
admet-292	376	48	the	the	DET
admet-292	376	49	alex	alex	PROPN
admet-292	376	50	avdeef	avdeef	PROPN
admet-292	376	51	et	et	PROPN
admet-292	376	52	al	al	PROPN
admet-292	376	53	.	.	PROPN
admet-292	376	54	admet	admet	PROPN
admet-292	376	55	&	&	CCONJ
admet-292	376	56	dmpk	dmpk	PROPN
admet-292	376	57	4(2	4(2	NUM
admet-292	376	58	)	)	PUNCT
admet-292	376	59	(	(	PUNCT
admet-292	376	60	2016	2016	NUM
admet-292	376	61	)	)	PUNCT
admet-292	376	62	117	117	NUM
admet-292	376	63	-	-	SYM
admet-292	376	64	178	178	NUM
admet-292	376	65	136	136	NUM
admet-292	376	66	aqueous	aqueous	ADJ
admet-292	376	67	solution	solution	NOUN
admet-292	376	68	.	.	PUNCT
admet-292	377	1	the	the	DET
admet-292	377	2	filtered	filter	VERB
admet-292	377	3	solid	solid	NOUN
admet-292	377	4	can	can	AUX
admet-292	377	5	show	show	VERB
admet-292	377	6	a	a	DET
admet-292	377	7	melting	melting	NOUN
admet-292	377	8	point	point	NOUN
admet-292	377	9	corresponding	correspond	VERB
admet-292	377	10	to	to	ADP
admet-292	377	11	crystalline	crystalline	ADJ
admet-292	377	12	drug	drug	NOUN
admet-292	377	13	salt	salt	NOUN
admet-292	377	14	,	,	PUNCT
admet-292	377	15	rather	rather	ADV
admet-292	377	16	than	than	ADP
admet-292	377	17	the	the	DET
admet-292	377	18	expected	expect	VERB
admet-292	377	19	free	free	ADJ
admet-292	377	20	base	base	NOUN
admet-292	377	21	.	.	PUNCT
admet-292	378	1	this	this	DET
admet-292	378	2	example	example	NOUN
admet-292	378	3	illustrates	illustrate	VERB
admet-292	378	4	the	the	DET
admet-292	378	5	value	value	NOUN
admet-292	378	6	of	of	ADP
admet-292	378	7	solid	solid	ADJ
admet-292	378	8	-	-	PUNCT
admet-292	378	9	state	state	NOUN
admet-292	378	10	characterization	characterization	NOUN
admet-292	378	11	and	and	CCONJ
admet-292	378	12	the	the	DET
admet-292	378	13	need	need	NOUN
admet-292	378	14	to	to	PART
admet-292	378	15	critically	critically	ADV
admet-292	378	16	examine	examine	VERB
admet-292	378	17	assay	assay	ADJ
admet-292	378	18	protocols	protocol	NOUN
admet-292	378	19	.	.	PUNCT
admet-292	379	1	5	5	NUM
admet-292	379	2	10	10	NUM
admet-292	379	3	15	15	NUM
admet-292	379	4	20	20	NUM
admet-292	379	5	25	25	NUM
admet-292	379	6	30	30	NUM
admet-292	379	7	35	35	NUM
admet-292	379	8	40	40	NUM
admet-292	379	9	2	2	NUM
admet-292	379	10	thetha	thetha	NOUN
admet-292	379	11	1	1	NUM
admet-292	379	12	2	2	NUM
admet-292	379	13	3	3	NUM
admet-292	379	14	25	25	NUM
admet-292	379	15	27	27	NUM
admet-292	379	16	29	29	NUM
admet-292	379	17	31	31	NUM
admet-292	379	18	33	33	NUM
admet-292	379	19	35	35	NUM
admet-292	379	20	1	1	NUM
admet-292	379	21	2	2	NUM
admet-292	379	22	5	5	NUM
admet-292	379	23	10	10	NUM
admet-292	379	24	15	15	NUM
admet-292	379	25	20	20	NUM
admet-292	379	26	25	25	NUM
admet-292	379	27	30	30	NUM
admet-292	379	28	35	35	NUM
admet-292	379	29	40	40	NUM
admet-292	379	30	2	2	NUM
admet-292	379	31	thetha	thetha	NOUN
admet-292	379	32	1	1	NUM
admet-292	379	33	2	2	NUM
admet-292	379	34	3	3	NUM
admet-292	379	35	25	25	NUM
admet-292	379	36	27	27	NUM
admet-292	379	37	29	29	NUM
admet-292	379	38	31	31	NUM
admet-292	379	39	33	33	NUM
admet-292	379	40	35	35	NUM
admet-292	379	41	1	1	NUM
admet-292	379	42	2	2	NUM
admet-292	379	43	2	2	NUM
admet-292	379	44	figure	figure	NOUN
admet-292	379	45	12	12	NUM
admet-292	379	46	.	.	PUNCT
admet-292	380	1	powder	powder	NOUN
admet-292	380	2	x	x	PROPN
admet-292	380	3	-	-	NOUN
admet-292	380	4	ray	ray	NOUN
admet-292	380	5	diffraction	diffraction	NOUN
admet-292	380	6	patterns	pattern	NOUN
admet-292	380	7	of	of	ADP
admet-292	380	8	α	α	PRON
admet-292	380	9	,	,	PUNCT
admet-292	380	10	ε’-	ε’-	PROPN
admet-292	380	11	,	,	PUNCT
admet-292	380	12	εpolymorphs	εpolymorph	NOUN
admet-292	380	13	of	of	ADP
admet-292	380	14	chlorpropamide	chlorpropamide	PROPN
admet-292	380	15	.	.	PUNCT
admet-292	381	1	note	note	VERB
admet-292	381	2	the	the	DET
admet-292	381	3	similarity	similarity	NOUN
admet-292	381	4	of	of	ADP
admet-292	381	5	the	the	DET
admet-292	381	6	patterns	pattern	NOUN
admet-292	381	7	of	of	ADP
admet-292	381	8	the	the	DET
admet-292	381	9	αand	αand	ADJ
admet-292	381	10	ε’polymorphs	ε’polymorph	NOUN
admet-292	381	11	at	at	ADP
admet-292	381	12	low	low	ADJ
admet-292	381	13	2	2	NOUN
admet-292	381	14	diffraction	diffraction	NOUN
admet-292	381	15	angles	angle	NOUN
admet-292	381	16	;	;	PUNCT
admet-292	381	17	zoomed	zoomed	PROPN
admet-292	381	18	insert	insert	PROPN
admet-292	381	19	enlarges	enlarge	VERB
admet-292	381	20	the	the	DET
admet-292	381	21	diffraction	diffraction	NOUN
admet-292	381	22	patterns	pattern	NOUN
admet-292	381	23	of	of	ADP
admet-292	381	24	1	1	NUM
admet-292	381	25	and	and	CCONJ
admet-292	381	26	2	2	NUM
admet-292	381	27	at	at	ADP
admet-292	381	28	higher	high	ADJ
admet-292	381	29	2	2	NOUN
admet-292	381	30	diffraction	diffraction	NOUN
admet-292	381	31	angles	angle	NOUN
admet-292	381	32	,	,	PUNCT
admet-292	381	33	where	where	SCONJ
admet-292	381	34	the	the	DET
admet-292	381	35	differences	difference	NOUN
admet-292	381	36	are	be	AUX
admet-292	381	37	pronounced	pronounce	VERB
admet-292	381	38	[	[	X
admet-292	381	39	80	80	NUM
admet-292	381	40	]	]	PUNCT
admet-292	381	41	.	.	PUNCT
admet-292	382	1	figure	figure	NOUN
admet-292	382	2	13	13	NUM
admet-292	382	3	.	.	PUNCT
admet-292	383	1	recrystallization	recrystallization	NOUN
admet-292	383	2	of	of	ADP
admet-292	383	3	tolazamide	tolazamide	PROPN
admet-292	383	4	polymorph	polymorph	NOUN
admet-292	383	5	ii	ii	PROPN
admet-292	383	6	(	(	PUNCT
admet-292	383	7	large	large	ADJ
admet-292	383	8	rhombic	rhombic	ADJ
admet-292	383	9	plates	plate	NOUN
admet-292	383	10	)	)	PUNCT
admet-292	383	11	into	into	ADP
admet-292	383	12	another	another	DET
admet-292	383	13	tolazamide	tolazamide	NOUN
admet-292	383	14	polymorph	polymorph	NOUN
admet-292	383	15	i	i	PRON
admet-292	383	16	(	(	PUNCT
admet-292	383	17	small	small	ADJ
admet-292	383	18	elongated	elongate	VERB
admet-292	383	19	prisms	prism	NOUN
admet-292	383	20	)	)	PUNCT
admet-292	384	1	[	[	X
admet-292	384	2	83	83	NUM
admet-292	384	3	]	]	PUNCT
admet-292	384	4	.	.	PUNCT
admet-292	385	1	as	as	SCONJ
admet-292	385	2	seen	see	VERB
admet-292	385	3	previously	previously	ADV
admet-292	385	4	(	(	PUNCT
admet-292	385	5	cf	cf	NOUN
admet-292	385	6	.	.	NUM
admet-292	385	7	,	,	PUNCT
admet-292	385	8	“	"	PUNCT
admet-292	385	9	potentiometric	potentiometric	ADJ
admet-292	385	10	cycling	cycling	NOUN
admet-292	385	11	for	for	ADP
admet-292	385	12	polymorph	polymorph	NOUN
admet-292	385	13	creation	creation	NOUN
admet-292	385	14	”	"	PUNCT
admet-292	385	15	)	)	PUNCT
admet-292	385	16	,	,	PUNCT
admet-292	385	17	there	there	PRON
admet-292	385	18	can	can	AUX
admet-292	385	19	be	be	AUX
admet-292	385	20	features	feature	NOUN
admet-292	385	21	in	in	ADP
admet-292	385	22	the	the	DET
admet-292	385	23	solubility	solubility	NOUN
admet-292	385	24	or	or	CCONJ
admet-292	385	25	dissolution	dissolution	NOUN
admet-292	385	26	curves	curve	NOUN
admet-292	385	27	which	which	PRON
admet-292	385	28	can	can	AUX
admet-292	385	29	suggest	suggest	VERB
admet-292	385	30	that	that	SCONJ
admet-292	385	31	the	the	DET
admet-292	385	32	composition	composition	NOUN
admet-292	385	33	of	of	ADP
admet-292	385	34	the	the	DET
admet-292	385	35	solid	solid	ADJ
admet-292	385	36	phase	phase	NOUN
admet-292	385	37	does	do	AUX
admet-292	385	38	change	change	VERB
admet-292	385	39	with	with	ADP
admet-292	385	40	time	time	NOUN
admet-292	385	41	,	,	PUNCT
admet-292	385	42	and	and	CCONJ
admet-292	385	43	the	the	DET
admet-292	385	44	results	result	NOUN
admet-292	385	45	at	at	ADP
admet-292	385	46	the	the	DET
admet-292	385	47	end	end	NOUN
admet-292	385	48	of	of	ADP
admet-292	385	49	the	the	DET
admet-292	385	50	measurements	measurement	NOUN
admet-292	385	51	refer	refer	VERB
admet-292	385	52	to	to	ADP
admet-292	385	53	another	another	DET
admet-292	385	54	phase	phase	NOUN
admet-292	385	55	than	than	ADP
admet-292	385	56	at	at	ADP
admet-292	385	57	the	the	DET
admet-292	385	58	beginning	beginning	NOUN
admet-292	385	59	.	.	PUNCT
admet-292	386	1	this	this	PRON
admet-292	386	2	can	can	AUX
admet-292	386	3	be	be	AUX
admet-292	386	4	further	far	ADV
admet-292	386	5	illustrated	illustrate	VERB
admet-292	386	6	with	with	ADP
admet-292	386	7	the	the	DET
admet-292	386	8	example	example	NOUN
admet-292	386	9	of	of	ADP
admet-292	386	10	l	l	ADJ
admet-292	386	11	-	-	ADJ
admet-292	386	12	glutamic	glutamic	ADJ
admet-292	386	13	acid	acid	NOUN
admet-292	386	14	.	.	PUNCT
admet-292	387	1	admet	admet	PROPN
admet-292	387	2	&	&	CCONJ
admet-292	387	3	dmpk	dmpk	PROPN
admet-292	387	4	4(2	4(2	NUM
admet-292	387	5	)	)	PUNCT
admet-292	387	6	(	(	PUNCT
admet-292	387	7	2016	2016	NUM
admet-292	387	8	)	)	PUNCT
admet-292	387	9	117	117	NUM
admet-292	387	10	-	-	SYM
admet-292	387	11	178	178	NUM
admet-292	387	12	consensus	consensus	NOUN
admet-292	387	13	recommendations	recommendation	NOUN
admet-292	387	14	for	for	ADP
admet-292	387	15	improving	improve	VERB
admet-292	387	16	solubility	solubility	NOUN
admet-292	387	17	-	-	PUNCT
admet-292	387	18	ph	ph	ADJ
admet-292	387	19	data	datum	NOUN
admet-292	387	20	quality	quality	NOUN
admet-292	387	21	doi	doi	NOUN
admet-292	387	22	:	:	PUNCT
admet-292	387	23	10.5599	10.5599	NUM
admet-292	387	24	/	/	SYM
admet-292	387	25	admet.4.2.292	admet.4.2.292	VERB
admet-292	387	26	137	137	NUM
admet-292	387	27	l	l	ADJ
admet-292	387	28	-	-	ADJ
admet-292	387	29	glutamic	glutamic	ADJ
admet-292	387	30	acid	acid	NOUN
admet-292	387	31	polymorphs	polymorphs	NOUN
admet-292	387	32	figure	figure	NOUN
admet-292	387	33	14a	14a	NOUN
admet-292	387	34	shows	show	VERB
admet-292	387	35	the	the	DET
admet-292	387	36	variation	variation	NOUN
admet-292	387	37	of	of	ADP
admet-292	387	38	the	the	DET
admet-292	387	39	concentration	concentration	NOUN
admet-292	387	40	of	of	ADP
admet-292	387	41	l	l	ADJ
admet-292	387	42	-	-	ADJ
admet-292	387	43	glutamic	glutamic	ADJ
admet-292	387	44	acid	acid	NOUN
admet-292	387	45	in	in	ADP
admet-292	387	46	aqueous	aqueous	ADJ
admet-292	387	47	suspension	suspension	NOUN
admet-292	387	48	.	.	PUNCT
admet-292	388	1	one	one	PRON
admet-292	388	2	can	can	AUX
admet-292	388	3	notice	notice	VERB
admet-292	388	4	,	,	PUNCT
admet-292	388	5	that	that	SCONJ
admet-292	388	6	the	the	DET
admet-292	388	7	saturated	saturate	VERB
admet-292	388	8	concentrations	concentration	NOUN
admet-292	388	9	start	start	AUX
admet-292	388	10	decreasing	decrease	VERB
admet-292	388	11	after	after	ADP
admet-292	388	12	some	some	DET
admet-292	388	13	time	time	NOUN
admet-292	388	14	.	.	PUNCT
admet-292	389	1	an	an	DET
admet-292	389	2	explanation	explanation	NOUN
admet-292	389	3	of	of	ADP
admet-292	389	4	this	this	DET
admet-292	389	5	phenomenon	phenomenon	NOUN
admet-292	389	6	can	can	AUX
admet-292	389	7	be	be	AUX
admet-292	389	8	provided	provide	VERB
admet-292	389	9	by	by	ADP
admet-292	389	10	figure	figure	NOUN
admet-292	389	11	14b	14b	NUM
admet-292	389	12	,	,	PUNCT
admet-292	389	13	in	in	ADP
admet-292	389	14	which	which	PRON
admet-292	389	15	the	the	DET
admet-292	389	16	relative	relative	ADJ
admet-292	389	17	contents	content	NOUN
admet-292	389	18	of	of	ADP
admet-292	389	19	the	the	DET
admet-292	389	20	more	more	ADV
admet-292	389	21	soluble	soluble	ADJ
admet-292	389	22	polymorph	polymorph	NOUN
admet-292	389	23	,	,	PUNCT
admet-292	389	24	the	the	DET
admet-292	389	25	α	α	NOUN
admet-292	389	26	-	-	PUNCT
admet-292	389	27	l	l	NOUN
admet-292	389	28	-	-	NOUN
admet-292	389	29	glutamic	glutamic	NOUN
admet-292	389	30	,	,	PUNCT
admet-292	389	31	in	in	ADP
admet-292	389	32	the	the	DET
admet-292	389	33	solid	solid	ADJ
admet-292	389	34	phase	phase	NOUN
admet-292	389	35	in	in	ADP
admet-292	389	36	contact	contact	NOUN
admet-292	389	37	with	with	ADP
admet-292	389	38	solution	solution	NOUN
admet-292	389	39	,	,	PUNCT
admet-292	389	40	is	be	AUX
admet-292	389	41	plotted	plot	VERB
admet-292	389	42	versus	versus	ADP
admet-292	389	43	time	time	NOUN
admet-292	389	44	of	of	ADP
admet-292	389	45	stirring	stir	VERB
admet-292	389	46	[	[	NOUN
admet-292	389	47	84	84	NUM
admet-292	389	48	]	]	PUNCT
admet-292	389	49	.	.	PUNCT
admet-292	390	1	figure	figure	NOUN
admet-292	390	2	14	14	NUM
admet-292	390	3	.	.	PUNCT
admet-292	391	1	(	(	PUNCT
admet-292	391	2	a	a	X
admet-292	391	3	)	)	PUNCT
admet-292	391	4	variation	variation	NOUN
admet-292	391	5	of	of	ADP
admet-292	391	6	the	the	DET
admet-292	391	7	concentration	concentration	NOUN
admet-292	391	8	of	of	ADP
admet-292	391	9	l	l	ADJ
admet-292	391	10	-	-	ADJ
admet-292	391	11	glutamic	glutamic	ADJ
admet-292	391	12	acid	acid	NOUN
admet-292	391	13	in	in	ADP
admet-292	391	14	aqueous	aqueous	ADJ
admet-292	391	15	solution	solution	NOUN
admet-292	391	16	versus	versus	ADP
admet-292	391	17	time	time	NOUN
admet-292	391	18	at	at	ADP
admet-292	391	19	35	35	NUM
admet-292	391	20	°	°	NOUN
admet-292	391	21	c	c	NOUN
admet-292	391	22	and	and	CCONJ
admet-292	391	23	50	50	NUM
admet-292	391	24	°	°	NOUN
admet-292	391	25	c	c	NOUN
admet-292	391	26	.	.	PUNCT
admet-292	392	1	(	(	PUNCT
admet-292	392	2	b	b	X
admet-292	392	3	)	)	PUNCT
admet-292	392	4	the	the	DET
admet-292	392	5	content	content	NOUN
admet-292	392	6	of	of	ADP
admet-292	392	7	the	the	DET
admet-292	392	8	α	α	NOUN
admet-292	392	9	-	-	PUNCT
admet-292	392	10	polymorph	polymorph	NOUN
admet-292	392	11	of	of	ADP
admet-292	392	12	l	l	ADJ
admet-292	392	13	-	-	ADJ
admet-292	392	14	glutamic	glutamic	ADJ
admet-292	392	15	acid	acid	NOUN
admet-292	392	16	in	in	ADP
admet-292	392	17	the	the	DET
admet-292	392	18	solid	solid	ADJ
admet-292	392	19	sample	sample	NOUN
admet-292	392	20	stored	store	VERB
admet-292	392	21	in	in	ADP
admet-292	392	22	aqueous	aqueous	ADJ
admet-292	392	23	solution	solution	NOUN
admet-292	392	24	at	at	ADP
admet-292	392	25	35	35	NUM
admet-292	392	26	°	°	NOUN
admet-292	392	27	c	c	NOUN
admet-292	392	28	,	,	PUNCT
admet-292	392	29	50	50	NUM
admet-292	392	30	°	°	NOUN
admet-292	392	31	c	c	NOUN
admet-292	392	32	,	,	PUNCT
admet-292	392	33	70	70	NUM
admet-292	392	34	°	°	NOUN
admet-292	392	35	c	c	NOUN
admet-292	392	36	;	;	PUNCT
admet-292	392	37	data	datum	NOUN
admet-292	392	38	from	from	ADP
admet-292	392	39	[	[	X
admet-292	392	40	85	85	NUM
admet-292	392	41	]	]	PUNCT
admet-292	392	42	.	.	PUNCT
admet-292	393	1	the	the	DET
admet-292	393	2	β	β	NOUN
admet-292	393	3	-	-	ADJ
admet-292	393	4	l	l	ADJ
admet-292	393	5	-	-	ADJ
admet-292	393	6	glutamic	glutamic	ADJ
admet-292	393	7	acid	acid	NOUN
admet-292	393	8	is	be	AUX
admet-292	393	9	the	the	DET
admet-292	393	10	more	more	ADV
admet-292	393	11	stable	stable	ADJ
admet-292	393	12	form	form	NOUN
admet-292	393	13	of	of	ADP
admet-292	393	14	l	l	ADJ
admet-292	393	15	-	-	ADJ
admet-292	393	16	glutamic	glutamic	ADJ
admet-292	393	17	acid	acid	NOUN
admet-292	394	1	[	[	X
admet-292	394	2	84	84	NUM
admet-292	394	3	]	]	PUNCT
admet-292	394	4	.	.	PUNCT
admet-292	395	1	the	the	DET
admet-292	395	2	αto	αto	PROPN
admet-292	395	3	β	β	NOUN
admet-292	395	4	-	-	PUNCT
admet-292	395	5	form	form	NOUN
admet-292	395	6	transition	transition	NOUN
admet-292	395	7	can	can	AUX
admet-292	395	8	proceed	proceed	VERB
admet-292	395	9	also	also	ADV
admet-292	395	10	in	in	ADP
admet-292	395	11	the	the	DET
admet-292	395	12	solid	solid	ADJ
admet-292	395	13	state	state	NOUN
admet-292	395	14	under	under	ADP
admet-292	395	15	humid	humid	ADJ
admet-292	395	16	conditions	condition	NOUN
admet-292	395	17	,	,	PUNCT
admet-292	395	18	although	although	SCONJ
admet-292	395	19	very	very	ADV
admet-292	395	20	slowly	slowly	ADV
admet-292	395	21	(	(	PUNCT
admet-292	395	22	being	be	AUX
admet-292	395	23	far	far	ADV
admet-292	395	24	from	from	ADP
admet-292	395	25	completion	completion	NOUN
admet-292	395	26	even	even	ADV
admet-292	395	27	after	after	ADP
admet-292	395	28	several	several	ADJ
admet-292	395	29	months	month	NOUN
admet-292	396	1	[	[	X
admet-292	396	2	84	84	NUM
admet-292	396	3	,	,	PUNCT
admet-292	396	4	85	85	NUM
admet-292	396	5	]	]	PUNCT
admet-292	396	6	.	.	PUNCT
admet-292	397	1	interestingly	interestingly	ADV
admet-292	397	2	,	,	PUNCT
admet-292	397	3	no	no	DET
admet-292	397	4	transition	transition	NOUN
admet-292	397	5	was	be	AUX
admet-292	397	6	observed	observe	VERB
admet-292	397	7	on	on	ADP
admet-292	397	8	heating	heat	VERB
admet-292	397	9	a	a	DET
admet-292	397	10	dry	dry	ADJ
admet-292	397	11	crystal	crystal	NOUN
admet-292	397	12	of	of	ADP
admet-292	397	13	the	the	DET
admet-292	397	14	α	α	NOUN
admet-292	397	15	-	-	NOUN
admet-292	397	16	form	form	NOUN
admet-292	397	17	.	.	PUNCT
admet-292	398	1	in	in	ADP
admet-292	398	2	solution	solution	NOUN
admet-292	398	3	,	,	PUNCT
admet-292	398	4	when	when	SCONJ
admet-292	398	5	the	the	DET
admet-292	398	6	crystals	crystal	NOUN
admet-292	398	7	of	of	ADP
admet-292	398	8	the	the	DET
admet-292	398	9	β	β	NOUN
admet-292	398	10	-	-	PUNCT
admet-292	398	11	form	form	NOUN
admet-292	398	12	precipitate	precipitate	NOUN
admet-292	398	13	,	,	PUNCT
admet-292	398	14	they	they	PRON
admet-292	398	15	deposit	deposit	VERB
admet-292	398	16	mainly	mainly	ADV
admet-292	398	17	on	on	ADP
admet-292	398	18	the	the	DET
admet-292	398	19	surface	surface	NOUN
admet-292	398	20	of	of	ADP
admet-292	398	21	α	α	NOUN
admet-292	398	22	-	-	NOUN
admet-292	398	23	crystals	crystal	NOUN
admet-292	398	24	,	,	PUNCT
admet-292	398	25	rather	rather	ADV
admet-292	398	26	than	than	ADP
admet-292	398	27	as	as	SCONJ
admet-292	398	28	single	single	ADJ
admet-292	398	29	crystals	crystal	NOUN
admet-292	398	30	suspended	suspend	VERB
admet-292	398	31	in	in	ADP
admet-292	398	32	solution	solution	NOUN
admet-292	398	33	and	and	CCONJ
admet-292	398	34	the	the	DET
admet-292	398	35	two	two	NUM
admet-292	398	36	forms	form	NOUN
admet-292	398	37	can	can	AUX
admet-292	398	38	fuse	fuse	VERB
admet-292	398	39	into	into	ADP
admet-292	398	40	each	each	DET
admet-292	398	41	other	other	ADJ
admet-292	398	42	to	to	ADP
admet-292	398	43	such	such	DET
admet-292	398	44	an	an	DET
admet-292	398	45	extent	extent	NOUN
admet-292	398	46	,	,	PUNCT
admet-292	398	47	that	that	SCONJ
admet-292	398	48	their	their	PRON
admet-292	398	49	co	co	NOUN
admet-292	398	50	-	-	NOUN
admet-292	398	51	existence	existence	NOUN
admet-292	398	52	could	could	AUX
admet-292	398	53	be	be	AUX
admet-292	398	54	revealed	reveal	VERB
admet-292	398	55	only	only	ADV
admet-292	398	56	by	by	ADP
admet-292	398	57	pxrd	pxrd	NOUN
admet-292	398	58	,	,	PUNCT
admet-292	398	59	but	but	CCONJ
admet-292	398	60	not	not	PART
admet-292	398	61	by	by	ADP
admet-292	398	62	optical	optical	ADJ
admet-292	398	63	microscopy	microscopy	NOUN
admet-292	398	64	[	[	X
admet-292	398	65	84	84	NUM
admet-292	398	66	,	,	PUNCT
admet-292	398	67	85	85	NUM
admet-292	398	68	]	]	PUNCT
admet-292	398	69	.	.	PUNCT
admet-292	399	1	in	in	ADP
admet-292	399	2	figure	figure	NOUN
admet-292	399	3	15	15	NUM
admet-292	399	4	the	the	DET
admet-292	399	5	data	datum	NOUN
admet-292	399	6	from	from	ADP
admet-292	399	7	sakata	sakata	NOUN
admet-292	399	8	[	[	X
admet-292	399	9	85	85	NUM
admet-292	399	10	]	]	PUNCT
admet-292	399	11	,	,	PUNCT
admet-292	399	12	processed	process	VERB
admet-292	399	13	using	use	VERB
admet-292	399	14	pdisol	pdisol	NOUN
admet-292	399	15	-	-	PUNCT
admet-292	399	16	x	x	NOUN
admet-292	399	17	,	,	PUNCT
admet-292	399	18	are	be	AUX
admet-292	399	19	presented	present	VERB
admet-292	399	20	in	in	ADP
admet-292	399	21	a	a	DET
admet-292	399	22	comparison	comparison	NOUN
admet-292	399	23	with	with	ADP
admet-292	399	24	similarly	similarly	ADV
admet-292	399	25	treated	treat	VERB
admet-292	399	26	data	datum	NOUN
admet-292	399	27	from	from	ADP
admet-292	399	28	lee	lee	PROPN
admet-292	399	29	et	et	PROPN
admet-292	399	30	al	al	PROPN
admet-292	399	31	.	.	PUNCT
admet-292	400	1	[	[	X
admet-292	400	2	86	86	NUM
admet-292	400	3	]	]	PUNCT
admet-292	400	4	.	.	PUNCT
admet-292	401	1	figure	figure	NOUN
admet-292	401	2	15a	15a	NOUN
admet-292	401	3	shows	show	VERB
admet-292	401	4	the	the	DET
admet-292	401	5	expected	expect	VERB
admet-292	401	6	parabolic	parabolic	NOUN
admet-292	401	7	-	-	PUNCT
admet-292	401	8	shaped	shape	VERB
admet-292	401	9	logs	log	NOUN
admet-292	401	10	-	-	PUNCT
admet-292	401	11	ph	ph	NOUN
admet-292	401	12	profile	profile	NOUN
admet-292	401	13	of	of	ADP
admet-292	401	14	l	l	ADJ
admet-292	401	15	-	-	ADJ
admet-292	401	16	glutamic	glutamic	ADJ
admet-292	401	17	acid	acid	NOUN
admet-292	401	18	,	,	PUNCT
admet-292	401	19	without	without	ADP
admet-292	401	20	indication	indication	NOUN
admet-292	401	21	of	of	ADP
admet-292	401	22	the	the	DET
admet-292	401	23	polymorphic	polymorphic	ADJ
admet-292	401	24	form	form	NOUN
admet-292	401	25	.	.	PUNCT
admet-292	402	1	from	from	ADP
admet-292	402	2	the	the	DET
admet-292	402	3	pdisol	pdisol	ADJ
admet-292	402	4	-	-	PUNCT
admet-292	402	5	x	x	NOUN
admet-292	402	6	analysis	analysis	NOUN
admet-292	402	7	of	of	ADP
admet-292	402	8	the	the	DET
admet-292	402	9	data	datum	NOUN
admet-292	402	10	,	,	PUNCT
admet-292	402	11	the	the	DET
admet-292	402	12	intrinsic	intrinsic	ADJ
admet-292	402	13	solubility	solubility	NOUN
admet-292	402	14	,	,	PUNCT
admet-292	402	15	s0	s0	PROPN
admet-292	402	16	,	,	PUNCT
admet-292	402	17	refined	refine	VERB
admet-292	402	18	to	to	ADP
admet-292	402	19	7.5	7.5	NUM
admet-292	402	20	±	±	NUM
admet-292	402	21	0.1	0.1	NUM
admet-292	402	22	mg	mg	PROPN
admet-292	402	23	/	/	SYM
admet-292	402	24	ml	ml	NOUN
admet-292	402	25	.	.	PUNCT
admet-292	402	26	figure	figure	NOUN
admet-292	402	27	15b	15b	NOUN
admet-292	402	28	shows	show	VERB
admet-292	402	29	the	the	DET
admet-292	402	30	result	result	NOUN
admet-292	402	31	of	of	ADP
admet-292	402	32	a	a	DET
admet-292	402	33	single	single	ADJ
admet-292	402	34	-	-	PUNCT
admet-292	402	35	point	point	NOUN
admet-292	402	36	analysis	analysis	NOUN
admet-292	402	37	of	of	ADP
admet-292	402	38	l	l	ADJ
admet-292	402	39	-	-	ADJ
admet-292	402	40	glutamic	glutamic	ADJ
admet-292	402	41	acid	acid	NOUN
admet-292	402	42	,	,	PUNCT
admet-292	402	43	known	know	VERB
admet-292	402	44	to	to	PART
admet-292	402	45	be	be	AUX
admet-292	402	46	in	in	ADP
admet-292	402	47	the	the	DET
admet-292	402	48	β	β	NOUN
admet-292	402	49	-	-	NOUN
admet-292	402	50	form	form	NOUN
admet-292	402	51	[	[	X
admet-292	402	52	85	85	NUM
admet-292	402	53	]	]	PUNCT
admet-292	402	54	,	,	PUNCT
admet-292	402	55	where	where	SCONJ
admet-292	402	56	the	the	DET
admet-292	402	57	refined	refined	ADJ
admet-292	402	58	s0	s0	NOUN
admet-292	402	59	=	=	PUNCT
admet-292	402	60	7.7	7.7	NUM
admet-292	402	61	mg	mg	NUM
admet-292	402	62	/	/	SYM
admet-292	402	63	ml	ml	NOUN
admet-292	402	64	.	.	PUNCT
admet-292	403	1	the	the	DET
admet-292	403	2	comparable	comparable	ADJ
admet-292	403	3	s0	s0	NOUN
admet-292	403	4	values	value	NOUN
admet-292	403	5	suggest	suggest	VERB
admet-292	403	6	that	that	SCONJ
admet-292	403	7	lee	lee	PROPN
admet-292	403	8	et	et	PROPN
admet-292	403	9	al	al	PROPN
admet-292	403	10	.	.	PUNCT
admet-292	404	1	[	[	X
admet-292	404	2	86	86	NUM
admet-292	404	3	]	]	PUNCT
admet-292	404	4	had	have	AUX
admet-292	404	5	performed	perform	VERB
admet-292	404	6	measurements	measurement	NOUN
admet-292	404	7	on	on	ADP
admet-292	404	8	the	the	DET
admet-292	404	9	stable	stable	ADJ
admet-292	404	10	β	β	NOUN
admet-292	404	11	-	-	NOUN
admet-292	404	12	form	form	NOUN
admet-292	404	13	.	.	PUNCT
admet-292	405	1	it	it	PRON
admet-292	405	2	is	be	AUX
admet-292	405	3	worth	worth	ADJ
admet-292	405	4	pointing	point	VERB
admet-292	405	5	out	out	ADP
admet-292	405	6	that	that	SCONJ
admet-292	405	7	on	on	ADP
admet-292	405	8	examination	examination	NOUN
admet-292	405	9	of	of	ADP
admet-292	405	10	the	the	DET
admet-292	405	11	sakata	sakata	NOUN
admet-292	405	12	publication	publication	NOUN
admet-292	405	13	[	[	X
admet-292	405	14	85	85	NUM
admet-292	405	15	]	]	PUNCT
admet-292	405	16	,	,	PUNCT
admet-292	405	17	one	one	PRON
admet-292	405	18	encounters	encounter	VERB
admet-292	405	19	several	several	ADJ
admet-292	405	20	shortcomings	shortcoming	NOUN
admet-292	405	21	in	in	ADP
admet-292	405	22	method	method	ADJ
admet-292	405	23	description	description	NOUN
admet-292	405	24	,	,	PUNCT
admet-292	405	25	which	which	PRON
admet-292	405	26	are	be	AUX
admet-292	405	27	,	,	PUNCT
admet-292	405	28	unfortunately	unfortunately	ADV
admet-292	405	29	,	,	PUNCT
admet-292	405	30	rather	rather	ADV
admet-292	405	31	common	common	ADJ
admet-292	405	32	when	when	SCONJ
admet-292	405	33	examining	examine	VERB
admet-292	405	34	published	publish	VERB
admet-292	405	35	results	result	NOUN
admet-292	405	36	.	.	PUNCT
admet-292	406	1	first	first	ADV
admet-292	406	2	,	,	PUNCT
admet-292	406	3	solubility	solubility	NOUN
admet-292	406	4	has	have	AUX
admet-292	406	5	been	be	AUX
admet-292	406	6	reported	report	VERB
admet-292	406	7	in	in	ADP
admet-292	406	8	units	unit	NOUN
admet-292	406	9	of	of	ADP
admet-292	406	10	“	"	PUNCT
admet-292	406	11	g	g	NOUN
admet-292	406	12	solute	solute	NOUN
admet-292	406	13	per	per	ADP
admet-292	406	14	100	100	NUM
admet-292	406	15	g	g	NOUN
admet-292	406	16	water	water	NOUN
admet-292	406	17	.	.	PUNCT
admet-292	406	18	”	"	PUNCT
admet-292	407	1	given	give	VERB
admet-292	407	2	that	that	DET
admet-292	407	3	100	100	NUM
admet-292	407	4	mg	mg	NOUN
admet-292	407	5	of	of	ADP
admet-292	407	6	naxh.h2o	naxh.h2o	NOUN
admet-292	407	7	plus	plus	CCONJ
admet-292	407	8	1	1	NUM
admet-292	407	9	equiv	equiv	NOUN
admet-292	407	10	.	.	PUNCT
admet-292	408	1	of	of	ADP
admet-292	408	2	hcl	hcl	PROPN
admet-292	409	1	had	have	AUX
admet-292	409	2	been	be	AUX
admet-292	409	3	introduced	introduce	VERB
admet-292	409	4	to	to	ADP
admet-292	409	5	water	water	NOUN
admet-292	409	6	,	,	PUNCT
admet-292	409	7	it	it	PRON
admet-292	409	8	is	be	AUX
admet-292	409	9	not	not	PART
admet-292	409	10	clear	clear	ADJ
admet-292	409	11	,	,	PUNCT
admet-292	409	12	what	what	PRON
admet-292	409	13	is	be	AUX
admet-292	409	14	meant	mean	VERB
admet-292	409	15	by	by	ADP
admet-292	409	16	“	"	PUNCT
admet-292	409	17	solute	solute	VERB
admet-292	409	18	”	"	PUNCT
admet-292	409	19	,	,	PUNCT
admet-292	409	20	i.e.	i.e.	X
admet-292	409	21	,	,	PUNCT
admet-292	409	22	which	which	PRON
admet-292	409	23	formula	formula	NOUN
admet-292	409	24	weight	weight	NOUN
admet-292	409	25	should	should	AUX
admet-292	409	26	be	be	AUX
admet-292	409	27	used	use	VERB
admet-292	409	28	to	to	PART
admet-292	409	29	convert	convert	VERB
admet-292	409	30	to	to	ADP
admet-292	409	31	molality	molality	NOUN
admet-292	409	32	.	.	PUNCT
admet-292	410	1	the	the	DET
admet-292	410	2	result	result	NOUN
admet-292	410	3	closest	close	ADJ
admet-292	410	4	to	to	ADP
admet-292	410	5	that	that	PRON
admet-292	410	6	of	of	ADP
admet-292	410	7	lee	lee	PROPN
admet-292	410	8	et	et	PROPN
admet-292	410	9	al	al	PROPN
admet-292	410	10	.	.	PUNCT
admet-292	411	1	[	[	X
admet-292	411	2	86	86	NUM
admet-292	411	3	]	]	PUNCT
admet-292	411	4	suggests	suggest	VERB
admet-292	411	5	that	that	SCONJ
admet-292	411	6	“	"	PUNCT
admet-292	411	7	solute	solute	VERB
admet-292	411	8	”	"	PUNCT
admet-292	411	9	refers	refer	VERB
admet-292	411	10	to	to	ADP
admet-292	411	11	the	the	DET
admet-292	411	12	zwitterion	zwitterion	NOUN
admet-292	411	13	xh2	xh2	PROPN
admet-292	411	14	species	specie	NOUN
admet-292	411	15	,	,	PUNCT
admet-292	411	16	not	not	PART
admet-292	411	17	salt	salt	NOUN
admet-292	411	18	form	form	NOUN
admet-292	411	19	,	,	PUNCT
admet-292	411	20	naxh.h2o	naxh.h2o	NOUN
admet-292	411	21	,	,	PUNCT
admet-292	411	22	that	that	PRON
admet-292	411	23	was	be	AUX
admet-292	411	24	actually	actually	ADV
admet-292	411	25	added	add	VERB
admet-292	411	26	to	to	ADP
admet-292	411	27	the	the	DET
admet-292	411	28	solution	solution	NOUN
admet-292	411	29	.	.	PUNCT
admet-292	412	1	such	such	ADJ
admet-292	412	2	ambiguities	ambiguity	NOUN
admet-292	412	3	happen	happen	VERB
admet-292	412	4	quite	quite	ADV
admet-292	412	5	often	often	ADV
admet-292	412	6	in	in	ADP
admet-292	412	7	the	the	DET
admet-292	412	8	nearly	nearly	ADV
admet-292	412	9	850	850	NUM
admet-292	412	10	citations	citation	NOUN
admet-292	412	11	in	in	ADP
admet-292	412	12	the	the	DET
admet-292	412	13	solubility	solubility	NOUN
admet-292	412	14	database	database	NOUN
admet-292	412	15	[	[	X
admet-292	412	16	4	4	NUM
admet-292	412	17	]	]	PUNCT
admet-292	412	18	.	.	PUNCT
admet-292	413	1	clarifications	clarification	NOUN
admet-292	413	2	are	be	AUX
admet-292	413	3	often	often	ADV
admet-292	413	4	not	not	PART
admet-292	413	5	possible	possible	ADJ
admet-292	413	6	,	,	PUNCT
admet-292	413	7	since	since	SCONJ
admet-292	413	8	the	the	DET
admet-292	413	9	authors	author	NOUN
admet-292	413	10	are	be	AUX
admet-292	413	11	either	either	CCONJ
admet-292	413	12	no	no	ADV
admet-292	413	13	longer	long	ADV
admet-292	413	14	active	active	ADJ
admet-292	413	15	,	,	PUNCT
admet-292	413	16	or	or	CCONJ
admet-292	413	17	the	the	DET
admet-292	413	18	original	original	ADJ
admet-292	413	19	experimental	experimental	ADJ
admet-292	413	20	data	datum	NOUN
admet-292	413	21	can	can	AUX
admet-292	413	22	not	not	PART
admet-292	413	23	be	be	AUX
admet-292	413	24	located	locate	VERB
admet-292	413	25	,	,	PUNCT
admet-292	413	26	or	or	CCONJ
admet-292	413	27	the	the	DET
admet-292	413	28	authors	author	NOUN
admet-292	413	29	are	be	AUX
admet-292	413	30	deceased	deceased	ADJ
admet-292	413	31	.	.	PUNCT
admet-292	414	1	second	second	ADV
admet-292	414	2	,	,	PUNCT
admet-292	414	3	the	the	DET
admet-292	414	4	final	final	ADJ
admet-292	414	5	ph	ph	NOUN
admet-292	414	6	value	value	NOUN
admet-292	414	7	was	be	AUX
admet-292	414	8	not	not	PART
admet-292	414	9	reported	report	VERB
admet-292	414	10	[	[	X
admet-292	414	11	85	85	NUM
admet-292	414	12	]	]	PUNCT
admet-292	414	13	.	.	PUNCT
admet-292	415	1	for	for	ADP
admet-292	415	2	l	l	ADJ
admet-292	415	3	-	-	ADJ
admet-292	415	4	glutamic	glutamic	ADJ
admet-292	415	5	acid	acid	NOUN
admet-292	415	6	,	,	PUNCT
admet-292	415	7	it	it	PRON
admet-292	415	8	does	do	AUX
admet-292	415	9	not	not	PART
admet-292	415	10	matter	matter	VERB
admet-292	415	11	much	much	ADV
admet-292	415	12	,	,	PUNCT
admet-292	415	13	though	though	SCONJ
admet-292	415	14	alex	alex	PROPN
admet-292	415	15	avdeef	avdeef	PROPN
admet-292	415	16	et	et	PROPN
admet-292	415	17	al	al	PROPN
admet-292	415	18	.	.	PROPN
admet-292	415	19	admet	admet	PROPN
admet-292	415	20	&	&	CCONJ
admet-292	415	21	dmpk	dmpk	PROPN
admet-292	415	22	4(2	4(2	NUM
admet-292	415	23	)	)	PUNCT
admet-292	415	24	(	(	PUNCT
admet-292	415	25	2016	2016	NUM
admet-292	415	26	)	)	PUNCT
admet-292	415	27	117	117	NUM
admet-292	415	28	-	-	SYM
admet-292	415	29	178	178	NUM
admet-292	415	30	138	138	NUM
admet-292	415	31	knowledge	knowledge	NOUN
admet-292	415	32	of	of	ADP
admet-292	415	33	the	the	DET
admet-292	415	34	phsat	phsat	NOUN
admet-292	415	35	becomes	become	VERB
admet-292	415	36	important	important	ADJ
admet-292	415	37	for	for	ADP
admet-292	415	38	low	low	ADJ
admet-292	415	39	soluble	soluble	ADJ
admet-292	415	40	molecules	molecule	NOUN
admet-292	415	41	(	(	PUNCT
admet-292	415	42	e.g.	e.g.	ADV
admet-292	415	43	,	,	PUNCT
admet-292	415	44	mefenamic	mefenamic	ADJ
admet-292	415	45	acid	acid	NOUN
admet-292	415	46	,	,	PUNCT
admet-292	415	47	diflunisal	diflunisal	NOUN
admet-292	415	48	,	,	PUNCT
admet-292	415	49	fenbufen	fenbufen	NOUN
admet-292	415	50	,	,	PUNCT
admet-292	415	51	indomethacin	indomethacin	NOUN
admet-292	415	52	,	,	PUNCT
admet-292	415	53	clofazimine	clofazimine	ADJ
admet-292	415	54	,	,	PUNCT
admet-292	415	55	terfenadine	terfenadine	NOUN
admet-292	415	56	)	)	PUNCT
admet-292	416	1	[	[	X
admet-292	416	2	4	4	NUM
admet-292	416	3	]	]	PUNCT
admet-292	416	4	.	.	PUNCT
admet-292	417	1	using	use	VERB
admet-292	417	2	pdisol	pdisol	ADJ
admet-292	417	3	-	-	PUNCT
admet-292	417	4	x	x	NOUN
admet-292	417	5	,	,	PUNCT
admet-292	417	6	the	the	DET
admet-292	417	7	two	two	NUM
admet-292	417	8	calculated	calculated	ADJ
admet-292	417	9	saturation	saturation	NOUN
admet-292	417	10	ph	ph	ADJ
admet-292	417	11	values	value	NOUN
admet-292	417	12	,	,	PUNCT
admet-292	417	13	phsat	phsat	ADJ
admet-292	417	14	,	,	PUNCT
admet-292	417	15	are	be	AUX
admet-292	417	16	3.38	3.38	NUM
admet-292	417	17	(	(	PUNCT
admet-292	417	18	salt	salt	NOUN
admet-292	417	19	)	)	PUNCT
admet-292	417	20	and	and	CCONJ
admet-292	417	21	3.37	3.37	NUM
admet-292	417	22	(	(	PUNCT
admet-292	417	23	zwitterion	zwitterion	NOUN
admet-292	417	24	)	)	PUNCT
admet-292	417	25	.	.	PUNCT
admet-292	418	1	third	third	ADJ
admet-292	418	2	,	,	PUNCT
admet-292	418	3	the	the	DET
admet-292	418	4	values	value	NOUN
admet-292	418	5	of	of	ADP
admet-292	418	6	ionic	ionic	ADJ
admet-292	418	7	strength	strength	NOUN
admet-292	418	8	have	have	AUX
admet-292	418	9	not	not	PART
admet-292	418	10	been	be	AUX
admet-292	418	11	reported	report	VERB
admet-292	418	12	.	.	PUNCT
admet-292	419	1	depending	depend	VERB
admet-292	419	2	on	on	ADP
admet-292	419	3	which	which	PRON
admet-292	419	4	formula	formula	NOUN
admet-292	419	5	weight	weight	NOUN
admet-292	419	6	assumptions	assumption	NOUN
admet-292	419	7	have	have	AUX
admet-292	419	8	been	be	AUX
admet-292	419	9	made	make	VERB
admet-292	419	10	,	,	PUNCT
admet-292	419	11	the	the	DET
admet-292	419	12	values	value	NOUN
admet-292	419	13	would	would	AUX
admet-292	419	14	be	be	AUX
admet-292	419	15	calculated	calculate	VERB
admet-292	419	16	as	as	ADP
admet-292	419	17	0.54	0.54	NUM
admet-292	419	18	or	or	CCONJ
admet-292	419	19	0.64	0.64	NUM
admet-292	419	20	m	m	NOUN
admet-292	419	21	,	,	PUNCT
admet-292	419	22	either	either	CCONJ
admet-292	419	23	value	value	VERB
admet-292	419	24	well	well	ADV
admet-292	419	25	above	above	ADP
admet-292	419	26	that	that	PRON
admet-292	419	27	of	of	ADP
admet-292	419	28	normal	normal	ADJ
admet-292	419	29	saline	saline	NOUN
admet-292	419	30	.	.	PUNCT
admet-292	420	1	figure	figure	NOUN
admet-292	420	2	15	15	NUM
admet-292	420	3	.	.	PUNCT
admet-292	421	1	the	the	DET
admet-292	421	2	data	datum	NOUN
admet-292	421	3	from	from	ADP
admet-292	421	4	sakata	sakata	NOUN
admet-292	421	5	[	[	X
admet-292	421	6	85	85	NUM
admet-292	421	7	]	]	X
admet-292	421	8	processed	process	VERB
admet-292	421	9	using	use	VERB
admet-292	421	10	pdisol	pdisol	NOUN
admet-292	421	11	-	-	PUNCT
admet-292	421	12	x	x	NOUN
admet-292	421	13	in	in	ADP
admet-292	421	14	a	a	DET
admet-292	421	15	comparison	comparison	NOUN
admet-292	421	16	with	with	ADP
admet-292	421	17	similarly	similarly	ADV
admet-292	421	18	treated	treat	VERB
admet-292	421	19	data	datum	NOUN
admet-292	421	20	from	from	ADP
admet-292	421	21	[	[	X
admet-292	421	22	86	86	NUM
admet-292	421	23	]	]	PUNCT
admet-292	421	24	.	.	PUNCT
admet-292	422	1	cocrystals	cocrystal	NOUN
admet-292	422	2	interest	interest	NOUN
admet-292	422	3	in	in	ADP
admet-292	422	4	pharmaceutical	pharmaceutical	ADJ
admet-292	422	5	cocrystals	cocrystal	NOUN
admet-292	422	6	emerged	emerge	VERB
admet-292	422	7	rapidly	rapidly	ADV
admet-292	422	8	in	in	ADP
admet-292	422	9	the	the	DET
admet-292	422	10	last	last	ADJ
admet-292	422	11	decade	decade	NOUN
admet-292	422	12	[	[	X
admet-292	422	13	30	30	NUM
admet-292	422	14	,	,	PUNCT
admet-292	422	15	87	87	NUM
admet-292	422	16	-	-	SYM
admet-292	422	17	96	96	NUM
admet-292	422	18	]	]	PUNCT
admet-292	422	19	.	.	PUNCT
admet-292	423	1	quite	quite	ADV
admet-292	423	2	often	often	ADV
admet-292	423	3	cocrystals	cocrystal	NOUN
admet-292	423	4	can	can	AUX
admet-292	423	5	be	be	AUX
admet-292	423	6	formed	form	VERB
admet-292	423	7	in	in	ADP
admet-292	423	8	the	the	DET
admet-292	423	9	physical	physical	ADJ
admet-292	423	10	mixtures	mixture	NOUN
admet-292	423	11	of	of	ADP
admet-292	423	12	the	the	DET
admet-292	423	13	two	two	NUM
admet-292	423	14	components	component	NOUN
admet-292	423	15	even	even	ADV
admet-292	423	16	without	without	ADP
admet-292	423	17	any	any	DET
admet-292	423	18	action	action	NOUN
admet-292	423	19	,	,	PUNCT
admet-292	423	20	merely	merely	ADV
admet-292	423	21	due	due	ADJ
admet-292	423	22	to	to	ADP
admet-292	423	23	moisture	moisture	NOUN
admet-292	423	24	sorption	sorption	NOUN
admet-292	423	25	by	by	ADP
admet-292	423	26	components	component	NOUN
admet-292	423	27	themselves	themselves	PRON
admet-292	423	28	[	[	X
admet-292	423	29	97	97	NUM
admet-292	423	30	]	]	X
admet-292	423	31	,	,	PUNCT
admet-292	423	32	or	or	CCONJ
admet-292	423	33	by	by	ADP
admet-292	423	34	a	a	DET
admet-292	423	35	polymer	polymer	NOUN
admet-292	423	36	excipient	excipient	NOUN
admet-292	423	37	[	[	X
admet-292	423	38	96	96	NUM
admet-292	423	39	,	,	PUNCT
admet-292	423	40	98	98	NUM
admet-292	423	41	]	]	PUNCT
admet-292	423	42	.	.	PUNCT
admet-292	424	1	presence	presence	NOUN
admet-292	424	2	of	of	ADP
admet-292	424	3	cocrystals	cocrystal	NOUN
admet-292	424	4	in	in	ADP
admet-292	424	5	the	the	DET
admet-292	424	6	drug	drug	NOUN
admet-292	424	7	formulation	formulation	NOUN
admet-292	424	8	is	be	AUX
admet-292	424	9	thus	thus	ADV
admet-292	424	10	possible	possible	ADJ
admet-292	424	11	even	even	ADV
admet-292	424	12	when	when	SCONJ
admet-292	424	13	not	not	PART
admet-292	424	14	anticipated	anticipate	VERB
admet-292	424	15	.	.	PUNCT
admet-292	425	1	cocrystals	cocrystal	NOUN
admet-292	425	2	are	be	AUX
admet-292	425	3	often	often	ADV
admet-292	425	4	designed	design	VERB
admet-292	425	5	and	and	CCONJ
admet-292	425	6	produced	produce	VERB
admet-292	425	7	on	on	ADP
admet-292	425	8	purpose	purpose	NOUN
admet-292	425	9	,	,	PUNCT
admet-292	425	10	to	to	PART
admet-292	425	11	increase	increase	VERB
admet-292	425	12	the	the	DET
admet-292	425	13	solubility	solubility	NOUN
admet-292	425	14	,	,	PUNCT
admet-292	425	15	or	or	CCONJ
admet-292	425	16	the	the	DET
admet-292	425	17	stability	stability	NOUN
admet-292	425	18	,	,	PUNCT
admet-292	425	19	or	or	CCONJ
admet-292	425	20	the	the	DET
admet-292	425	21	tabletability	tabletability	NOUN
admet-292	425	22	of	of	ADP
admet-292	425	23	an	an	DET
admet-292	425	24	active	active	ADJ
admet-292	425	25	pharmaceutical	pharmaceutical	ADJ
admet-292	425	26	ingredient	ingredient	NOUN
admet-292	425	27	(	(	PUNCT
admet-292	425	28	api	api	NOUN
admet-292	425	29	)	)	PUNCT
admet-292	426	1	[	[	X
admet-292	426	2	30	30	NUM
admet-292	426	3	,	,	PUNCT
admet-292	426	4	92	92	NUM
admet-292	426	5	,	,	PUNCT
admet-292	426	6	96	96	NUM
admet-292	426	7	,	,	PUNCT
admet-292	426	8	99	99	NUM
admet-292	426	9	-	-	SYM
admet-292	426	10	104	104	NUM
admet-292	426	11	]	]	PUNCT
admet-292	426	12	.	.	PUNCT
admet-292	427	1	however	however	ADV
admet-292	427	2	,	,	PUNCT
admet-292	427	3	when	when	SCONJ
admet-292	427	4	a	a	DET
admet-292	427	5	cocrystal	cocrystal	NOUN
admet-292	427	6	is	be	AUX
admet-292	427	7	dissolved	dissolve	VERB
admet-292	427	8	,	,	PUNCT
admet-292	427	9	the	the	DET
admet-292	427	10	initially	initially	ADV
admet-292	427	11	high	high	ADJ
admet-292	427	12	concentration	concentration	NOUN
admet-292	427	13	of	of	ADP
admet-292	427	14	the	the	DET
admet-292	427	15	api	api	NOUN
admet-292	427	16	in	in	ADP
admet-292	427	17	solution	solution	NOUN
admet-292	427	18	can	can	AUX
admet-292	427	19	drop	drop	VERB
admet-292	427	20	down	down	ADP
admet-292	427	21	with	with	ADP
admet-292	427	22	time	time	NOUN
admet-292	427	23	,	,	PUNCT
admet-292	427	24	and	and	CCONJ
admet-292	427	25	sometimes	sometimes	ADV
admet-292	427	26	this	this	PRON
admet-292	427	27	happens	happen	VERB
admet-292	427	28	very	very	ADV
admet-292	427	29	fast	fast	ADV
admet-292	427	30	.	.	PUNCT
admet-292	428	1	cocrystal	cocrystal	ADJ
admet-292	428	2	solubility	solubility	NOUN
admet-292	428	3	is	be	AUX
admet-292	428	4	sensitive	sensitive	ADJ
admet-292	428	5	to	to	ADP
admet-292	428	6	coformer	coformer	VERB
admet-292	428	7	concentration	concentration	NOUN
admet-292	428	8	and	and	CCONJ
admet-292	428	9	ph	ph	NOUN
admet-292	429	1	[	[	X
admet-292	429	2	31	31	NUM
admet-292	429	3	]	]	PUNCT
admet-292	429	4	.	.	PUNCT
admet-292	430	1	the	the	DET
admet-292	430	2	presence	presence	NOUN
admet-292	430	3	of	of	ADP
admet-292	430	4	surfactants	surfactant	NOUN
admet-292	430	5	can	can	AUX
admet-292	430	6	have	have	VERB
admet-292	430	7	a	a	DET
admet-292	430	8	pronounced	pronounce	VERB
admet-292	430	9	influence	influence	NOUN
admet-292	430	10	on	on	ADP
admet-292	430	11	the	the	DET
admet-292	430	12	dissolution	dissolution	NOUN
admet-292	430	13	of	of	ADP
admet-292	430	14	cocrystals	cocrystal	NOUN
admet-292	430	15	.	.	PUNCT
admet-292	431	1	surfactants	surfactant	NOUN
admet-292	431	2	are	be	AUX
admet-292	431	3	commonly	commonly	ADV
admet-292	431	4	used	use	VERB
admet-292	431	5	in	in	ADP
admet-292	431	6	pharmaceutical	pharmaceutical	ADJ
admet-292	431	7	development	development	NOUN
admet-292	431	8	,	,	PUNCT
admet-292	431	9	in	in	ADP
admet-292	431	10	dissolution	dissolution	ADJ
admet-292	431	11	media	medium	NOUN
admet-292	431	12	,	,	PUNCT
admet-292	431	13	as	as	ADP
admet-292	431	14	formulation	formulation	NOUN
admet-292	431	15	aids	aid	NOUN
admet-292	431	16	,	,	PUNCT
admet-292	431	17	to	to	PART
admet-292	431	18	enhance	enhance	VERB
admet-292	431	19	wetting	wetting	NOUN
admet-292	431	20	and	and	CCONJ
admet-292	431	21	solubility	solubility	NOUN
admet-292	431	22	of	of	ADP
admet-292	431	23	hydrophobic	hydrophobic	NOUN
admet-292	431	24	drugs	drug	NOUN
admet-292	431	25	[	[	X
admet-292	431	26	105	105	NUM
admet-292	431	27	,	,	PUNCT
admet-292	431	28	106	106	NUM
admet-292	431	29	]	]	PUNCT
admet-292	431	30	,	,	PUNCT
admet-292	431	31	and	and	CCONJ
admet-292	431	32	are	be	AUX
admet-292	431	33	,	,	PUNCT
admet-292	431	34	of	of	ADP
admet-292	431	35	course	course	NOUN
admet-292	431	36	,	,	PUNCT
admet-292	431	37	encountered	encounter	VERB
admet-292	431	38	in	in	ADP
admet-292	431	39	vivo	vivo	NOUN
admet-292	431	40	.	.	PUNCT
admet-292	432	1	whereas	whereas	SCONJ
admet-292	432	2	the	the	DET
admet-292	432	3	micellar	micellar	ADJ
admet-292	432	4	solubilization	solubilization	NOUN
admet-292	432	5	of	of	ADP
admet-292	432	6	single	single	ADJ
admet-292	432	7	-	-	PUNCT
admet-292	432	8	component	component	NOUN
admet-292	432	9	crystals	crystal	NOUN
admet-292	432	10	has	have	AUX
admet-292	432	11	been	be	AUX
admet-292	432	12	thoroughly	thoroughly	ADV
admet-292	432	13	studied	study	VERB
admet-292	432	14	,	,	PUNCT
admet-292	432	15	micellar	micellar	ADJ
admet-292	432	16	solubilization	solubilization	NOUN
admet-292	432	17	of	of	ADP
admet-292	432	18	cocrystals	cocrystal	NOUN
admet-292	432	19	is	be	AUX
admet-292	432	20	not	not	PART
admet-292	432	21	well	well	ADV
admet-292	432	22	understood	understand	VERB
admet-292	432	23	.	.	PUNCT
admet-292	433	1	a	a	DET
admet-292	433	2	key	key	ADJ
admet-292	433	3	question	question	NOUN
admet-292	433	4	is	be	AUX
admet-292	433	5	:	:	PUNCT
admet-292	433	6	how	how	SCONJ
admet-292	433	7	do	do	VERB
admet-292	433	8	surfactants	surfactant	NOUN
admet-292	433	9	that	that	PRON
admet-292	433	10	solubilize	solubilize	VERB
admet-292	433	11	the	the	DET
admet-292	433	12	drug	drug	NOUN
admet-292	433	13	,	,	PUNCT
admet-292	433	14	influence	influence	NOUN
admet-292	433	15	cocrystal	cocrystal	NOUN
admet-292	433	16	solubility	solubility	NOUN
admet-292	433	17	and	and	CCONJ
admet-292	433	18	dissolution	dissolution	NOUN
admet-292	434	1	[	[	X
admet-292	434	2	33	33	NUM
admet-292	434	3	,	,	PUNCT
admet-292	434	4	96	96	NUM
admet-292	434	5	]	]	PUNCT
admet-292	434	6	?	?	PUNCT
admet-292	435	1	the	the	DET
admet-292	435	2	solubility	solubility	NOUN
admet-292	435	3	of	of	ADP
admet-292	435	4	a	a	DET
admet-292	435	5	hydrophobic	hydrophobic	NOUN
admet-292	435	6	drug	drug	NOUN
admet-292	435	7	in	in	ADP
admet-292	435	8	aqueous	aqueous	ADJ
admet-292	435	9	solution	solution	NOUN
admet-292	435	10	depends	depend	VERB
admet-292	435	11	on	on	ADP
admet-292	435	12	the	the	DET
admet-292	435	13	total	total	ADJ
admet-292	435	14	surfactant	surfactant	ADJ
admet-292	435	15	concentration	concentration	NOUN
admet-292	435	16	[	[	X
admet-292	435	17	33	33	NUM
admet-292	435	18	]	]	PUNCT
admet-292	435	19	.	.	PUNCT
admet-292	436	1	solubility	solubility	NOUN
admet-292	436	2	curves	curve	NOUN
admet-292	436	3	of	of	ADP
admet-292	436	4	a	a	DET
admet-292	436	5	pure	pure	ADJ
admet-292	436	6	drug	drug	NOUN
admet-292	436	7	and	and	CCONJ
admet-292	436	8	a	a	DET
admet-292	436	9	cocrystal	cocrystal	ADJ
admet-292	436	10	intersect	intersect	NOUN
admet-292	436	11	at	at	ADP
admet-292	436	12	a	a	DET
admet-292	436	13	critical	critical	ADJ
admet-292	436	14	stabilization	stabilization	NOUN
admet-292	436	15	concentration	concentration	NOUN
admet-292	436	16	(	(	PUNCT
admet-292	436	17	csc	csc	ADJ
admet-292	436	18	)	)	PUNCT
admet-292	436	19	point	point	NOUN
admet-292	436	20	,	,	PUNCT
admet-292	436	21	which	which	PRON
admet-292	436	22	increases	increase	VERB
admet-292	436	23	with	with	ADP
admet-292	436	24	coformer	coformer	NOUN
admet-292	436	25	solubilization	solubilization	NOUN
admet-292	436	26	[	[	X
admet-292	436	27	33	33	NUM
admet-292	436	28	]	]	PUNCT
admet-292	436	29	.	.	PUNCT
admet-292	437	1	cocrystal	cocrystal	PROPN
admet-292	437	2	solubility	solubility	NOUN
admet-292	437	3	for	for	ADP
admet-292	437	4	cocrystal	cocrystal	ADJ
admet-292	437	5	r	r	NOUN
admet-292	437	6	-	-	PUNCT
admet-292	437	7	ha	ha	INTJ
admet-292	437	8	in	in	ADP
admet-292	437	9	micellar	micellar	ADJ
admet-292	437	10	solutions	solution	NOUN
admet-292	437	11	can	can	AUX
admet-292	437	12	be	be	AUX
admet-292	437	13	predicted	predict	VERB
admet-292	437	14	from	from	ADP
admet-292	437	15	ka	ka	PROPN
admet-292	437	16	and	and	CCONJ
admet-292	437	17	s0	s0	PROPN
admet-292	437	18	values	value	NOUN
admet-292	437	19	of	of	ADP
admet-292	437	20	cocrystal	cocrystal	ADJ
admet-292	437	21	components	component	NOUN
admet-292	437	22	(	(	PUNCT
admet-292	437	23	drug	drug	NOUN
admet-292	437	24	,	,	PUNCT
admet-292	437	25	coformer	coformer	NOUN
admet-292	437	26	)	)	PUNCT
admet-292	437	27	and	and	CCONJ
admet-292	437	28	ksp	ksp	PROPN
admet-292	437	29	of	of	ADP
admet-292	437	30	cocrystal	cocrystal	PROPN
admet-292	437	31	in	in	ADP
admet-292	437	32	blank	blank	ADJ
admet-292	437	33	media	medium	NOUN
admet-292	437	34	[	[	X
admet-292	437	35	28	28	NUM
admet-292	437	36	]	]	PUNCT
admet-292	437	37	.	.	PUNCT
admet-292	438	1	cocrystal	cocrystal	PROPN
admet-292	438	2	and	and	CCONJ
admet-292	438	3	drug	drug	NOUN
admet-292	438	4	solubilities	solubility	NOUN
admet-292	438	5	converge	converge	VERB
admet-292	438	6	as	as	SCONJ
admet-292	438	7	they	they	PRON
admet-292	438	8	approach	approach	VERB
admet-292	438	9	csc	csc	PROPN
admet-292	439	1	[	[	X
admet-292	439	2	83	83	NUM
admet-292	439	3	,	,	PUNCT
admet-292	439	4	107	107	NUM
admet-292	439	5	]	]	PUNCT
admet-292	439	6	.	.	PUNCT
admet-292	440	1	cocrystal	cocrystal	PROPN
admet-292	440	2	csc	csc	PROPN
admet-292	440	3	is	be	AUX
admet-292	440	4	highly	highly	ADV
admet-292	440	5	sensitive	sensitive	ADJ
admet-292	440	6	to	to	ADP
admet-292	440	7	ph	ph	NOUN
admet-292	440	8	[	[	PUNCT
admet-292	440	9	108	108	NUM
admet-292	440	10	]	]	PUNCT
admet-292	440	11	.	.	PUNCT
admet-292	441	1	a	a	DET
admet-292	441	2	key	key	ADJ
admet-292	441	3	parameter	parameter	NOUN
admet-292	441	4	,	,	PUNCT
admet-292	441	5	which	which	PRON
admet-292	441	6	enables	enable	VERB
admet-292	441	7	the	the	DET
admet-292	441	8	measurement	measurement	NOUN
admet-292	441	9	of	of	ADP
admet-292	441	10	cocrystal	cocrystal	ADJ
admet-292	441	11	solubility	solubility	NOUN
admet-292	441	12	and	and	CCONJ
admet-292	441	13	to	to	PART
admet-292	441	14	establish	establish	VERB
admet-292	441	15	stability	stability	NOUN
admet-292	441	16	regions	region	NOUN
admet-292	441	17	from	from	ADP
admet-292	441	18	a	a	DET
admet-292	441	19	single	single	ADJ
admet-292	441	20	experiment	experiment	NOUN
admet-292	441	21	,	,	PUNCT
admet-292	441	22	is	be	AUX
admet-292	441	23	the	the	DET
admet-292	441	24	eutectic	eutectic	ADJ
admet-292	441	25	,	,	PUNCT
admet-292	441	26	or	or	CCONJ
admet-292	441	27	transition	transition	NOUN
admet-292	441	28	point	point	NOUN
admet-292	441	29	(	(	PUNCT
admet-292	441	30	figure	figure	NOUN
admet-292	441	31	16	16	NUM
admet-292	441	32	)	)	PUNCT
admet-292	442	1	[	[	X
admet-292	442	2	28	28	NUM
admet-292	442	3	]	]	PUNCT
admet-292	442	4	.	.	PUNCT
admet-292	443	1	at	at	ADP
admet-292	443	2	this	this	DET
admet-292	443	3	point	point	NOUN
admet-292	443	4	,	,	PUNCT
admet-292	443	5	admet	admet	PROPN
admet-292	443	6	&	&	CCONJ
admet-292	443	7	dmpk	dmpk	PROPN
admet-292	443	8	4(2	4(2	NUM
admet-292	443	9	)	)	PUNCT
admet-292	443	10	(	(	PUNCT
admet-292	443	11	2016	2016	NUM
admet-292	443	12	)	)	PUNCT
admet-292	443	13	117	117	NUM
admet-292	443	14	-	-	SYM
admet-292	443	15	178	178	NUM
admet-292	443	16	consensus	consensus	NOUN
admet-292	443	17	recommendations	recommendation	NOUN
admet-292	443	18	for	for	ADP
admet-292	443	19	improving	improve	VERB
admet-292	443	20	solubility	solubility	NOUN
admet-292	443	21	-	-	PUNCT
admet-292	443	22	ph	ph	ADJ
admet-292	443	23	data	datum	NOUN
admet-292	443	24	quality	quality	NOUN
admet-292	443	25	doi	doi	NOUN
admet-292	443	26	:	:	PUNCT
admet-292	443	27	10.5599	10.5599	NUM
admet-292	443	28	/	/	SYM
admet-292	443	29	admet.4.2.292	admet.4.2.292	NUM
admet-292	443	30	139	139	NUM
admet-292	443	31	scocrystal	scocrystal	ADJ
admet-292	443	32	=	=	VERB
admet-292	443	33	sdrug	sdrug	NOUN
admet-292	443	34	(	(	PUNCT
admet-292	443	35	cocrystal	cocrystal	ADJ
admet-292	443	36	solubility	solubility	NOUN
admet-292	443	37	in	in	ADP
admet-292	443	38	terms	term	NOUN
admet-292	443	39	of	of	ADP
admet-292	443	40	drug	drug	NOUN
admet-292	443	41	moles	mole	NOUN
admet-292	443	42	)	)	PUNCT
admet-292	443	43	;	;	PUNCT
admet-292	443	44	two	two	NUM
admet-292	443	45	solid	solid	ADJ
admet-292	443	46	phases	phase	NOUN
admet-292	443	47	are	be	AUX
admet-292	443	48	in	in	ADP
admet-292	443	49	equilibrium	equilibrium	NOUN
admet-292	443	50	with	with	ADP
admet-292	443	51	solution	solution	NOUN
admet-292	443	52	;	;	PUNCT
admet-292	443	53	solution	solution	NOUN
admet-292	443	54	composition	composition	NOUN
admet-292	444	1	[	[	X
admet-292	444	2	b]tr	b]tr	NOUN
admet-292	444	3	,	,	PUNCT
admet-292	444	4	[	[	X
admet-292	444	5	a]tr	a]tr	NOUN
admet-292	444	6	is	be	AUX
admet-292	444	7	fixed	fix	VERB
admet-292	444	8	at	at	ADP
admet-292	444	9	t	t	PROPN
admet-292	444	10	and	and	CCONJ
admet-292	444	11	ph	ph	VERB
admet-292	444	12	,	,	PUNCT
admet-292	444	13	regardless	regardless	ADV
admet-292	444	14	of	of	ADP
admet-292	444	15	ratio	ratio	NOUN
admet-292	444	16	of	of	ADP
admet-292	444	17	two	two	NUM
admet-292	444	18	solid	solid	ADJ
admet-292	444	19	phases	phase	NOUN
admet-292	444	20	[	[	X
admet-292	444	21	28	28	NUM
admet-292	444	22	]	]	PUNCT
admet-292	444	23	.	.	PUNCT
admet-292	445	1	figure	figure	NOUN
admet-292	445	2	16	16	NUM
admet-292	445	3	.	.	PUNCT
admet-292	446	1	a	a	DET
admet-292	446	2	schematic	schematic	ADJ
admet-292	446	3	representation	representation	NOUN
admet-292	446	4	for	for	ADP
admet-292	446	5	determining	determine	VERB
admet-292	446	6	the	the	DET
admet-292	446	7	eutectic	eutectic	ADJ
admet-292	446	8	,	,	PUNCT
admet-292	446	9	or	or	CCONJ
admet-292	446	10	transition	transition	NOUN
admet-292	446	11	point	point	NOUN
admet-292	446	12	“	"	PUNCT
admet-292	446	13	tr	tr	VERB
admet-292	446	14	”	"	PUNCT
admet-292	446	15	–	–	PUNCT
admet-292	446	16	the	the	DET
admet-292	446	17	point	point	NOUN
admet-292	446	18	at	at	ADP
admet-292	446	19	which	which	PRON
admet-292	446	20	the	the	DET
admet-292	446	21	“	"	PUNCT
admet-292	446	22	solubility	solubility	NOUN
admet-292	446	23	of	of	ADP
admet-292	446	24	ab	ab	PROPN
admet-292	446	25	versus	versus	ADP
admet-292	446	26	concentration	concentration	NOUN
admet-292	446	27	of	of	ADP
admet-292	446	28	b	b	NOUN
admet-292	446	29	”	"	PUNCT
admet-292	446	30	curve	curve	NOUN
admet-292	446	31	crosses	crosse	NOUN
admet-292	446	32	the	the	DET
admet-292	446	33	“	"	PUNCT
admet-292	446	34	solubility	solubility	NOUN
admet-292	446	35	of	of	ADP
admet-292	446	36	a	a	DET
admet-292	446	37	versus	versus	ADP
admet-292	446	38	concentration	concentration	NOUN
admet-292	446	39	of	of	ADP
admet-292	446	40	b	b	NOUN
admet-292	446	41	”	"	PUNCT
admet-292	446	42	curve	curve	NOUN
admet-292	446	43	.	.	PUNCT
admet-292	447	1	at	at	ADP
admet-292	447	2	this	this	DET
admet-292	447	3	point	point	NOUN
admet-292	447	4	scocrystal	scocrystal	ADJ
admet-292	447	5	=	=	VERB
admet-292	447	6	sdrug	sdrug	NOUN
admet-292	447	7	(	(	PUNCT
admet-292	447	8	cocrystal	cocrystal	ADJ
admet-292	447	9	solubility	solubility	NOUN
admet-292	447	10	in	in	ADP
admet-292	447	11	terms	term	NOUN
admet-292	447	12	of	of	ADP
admet-292	447	13	drug	drug	NOUN
admet-292	447	14	moles	mole	NOUN
admet-292	447	15	)	)	PUNCT
admet-292	447	16	,	,	PUNCT
admet-292	447	17	and	and	CCONJ
admet-292	447	18	the	the	DET
admet-292	447	19	two	two	NUM
admet-292	447	20	solid	solid	ADJ
admet-292	447	21	phases	phase	NOUN
admet-292	447	22	(	(	PUNCT
admet-292	447	23	ab	ab	NOUN
admet-292	447	24	and	and	CCONJ
admet-292	447	25	a	a	PRON
admet-292	447	26	)	)	PUNCT
admet-292	447	27	are	be	AUX
admet-292	447	28	in	in	ADP
admet-292	447	29	equilibrium	equilibrium	NOUN
admet-292	447	30	with	with	ADP
admet-292	447	31	the	the	DET
admet-292	447	32	solution	solution	NOUN
admet-292	447	33	.	.	PUNCT
admet-292	448	1	the	the	DET
admet-292	448	2	solution	solution	NOUN
admet-292	448	3	composition	composition	NOUN
admet-292	448	4	[	[	X
admet-292	448	5	b]tr	b]tr	NOUN
admet-292	448	6	,	,	PUNCT
admet-292	448	7	[	[	X
admet-292	448	8	a]tr	a]tr	NOUN
admet-292	448	9	is	be	AUX
admet-292	448	10	fixed	fix	VERB
admet-292	448	11	at	at	ADP
admet-292	448	12	t	t	PROPN
admet-292	448	13	and	and	CCONJ
admet-292	448	14	ph	ph	VERB
admet-292	448	15	,	,	PUNCT
admet-292	448	16	regardless	regardless	ADV
admet-292	448	17	of	of	ADP
admet-292	448	18	ratio	ratio	NOUN
admet-292	448	19	of	of	ADP
admet-292	448	20	two	two	NUM
admet-292	448	21	solid	solid	ADJ
admet-292	448	22	phases	phase	NOUN
admet-292	448	23	.	.	PUNCT
admet-292	449	1	adapted	adapt	VERB
admet-292	449	2	from	from	ADP
admet-292	449	3	[	[	X
admet-292	449	4	28	28	NUM
admet-292	449	5	]	]	PUNCT
admet-292	449	6	.	.	PUNCT
admet-292	450	1	carbamazepine	carbamazepine	NOUN
admet-292	450	2	-	-	PUNCT
admet-292	450	3	nicotinamide	nicotinamide	NOUN
admet-292	450	4	cocrystal	cocrystal	ADJ
admet-292	450	5	figure	figure	NOUN
admet-292	450	6	17	17	NUM
admet-292	451	1	[	[	SYM
admet-292	451	2	108	108	NUM
admet-292	451	3	]	]	PUNCT
admet-292	451	4	illustrates	illustrate	VERB
admet-292	451	5	the	the	DET
admet-292	451	6	fast	fast	ADJ
admet-292	451	7	drop	drop	NOUN
admet-292	451	8	in	in	ADP
admet-292	451	9	the	the	DET
admet-292	451	10	carbamazepine	carbamazepine	NOUN
admet-292	451	11	concentration	concentration	NOUN
admet-292	451	12	,	,	PUNCT
admet-292	451	13	as	as	SCONJ
admet-292	451	14	indicated	indicate	VERB
admet-292	451	15	by	by	ADP
admet-292	451	16	the	the	DET
admet-292	451	17	shift	shift	NOUN
admet-292	451	18	in	in	ADP
admet-292	451	19	the	the	DET
admet-292	451	20	uv	uv	NOUN
admet-292	451	21	absorption	absorption	NOUN
admet-292	451	22	maximum	maximum	NOUN
admet-292	451	23	,	,	PUNCT
admet-292	451	24	on	on	ADP
admet-292	451	25	dissolution	dissolution	NOUN
admet-292	451	26	of	of	ADP
admet-292	451	27	a	a	DET
admet-292	451	28	carbamazepine	carbamazepine	NOUN
admet-292	451	29	-	-	PUNCT
admet-292	451	30	nicotinamide	nicotinamide	NOUN
admet-292	451	31	1:1	1:1	NUM
admet-292	451	32	cocrystal	cocrystal	PROPN
admet-292	451	33	in	in	ADP
admet-292	451	34	water	water	NOUN
admet-292	451	35	.	.	PUNCT
admet-292	452	1	two	two	NUM
admet-292	452	2	minutes	minute	NOUN
admet-292	452	3	after	after	ADP
admet-292	452	4	the	the	DET
admet-292	452	5	start	start	NOUN
admet-292	452	6	of	of	ADP
admet-292	452	7	the	the	DET
admet-292	452	8	dissolution	dissolution	NOUN
admet-292	452	9	of	of	ADP
admet-292	452	10	the	the	DET
admet-292	452	11	carbamazepine	carbamazepine	NOUN
admet-292	452	12	-	-	PUNCT
admet-292	452	13	nicotinamide	nicotinamide	NOUN
admet-292	452	14	cocrystal	cocrystal	NOUN
admet-292	452	15	,	,	PUNCT
admet-292	452	16	the	the	DET
admet-292	452	17	solid	solid	ADJ
admet-292	452	18	sample	sample	NOUN
admet-292	452	19	transforms	transform	VERB
admet-292	452	20	almost	almost	ADV
admet-292	452	21	completely	completely	ADV
admet-292	452	22	into	into	ADP
admet-292	452	23	the	the	DET
admet-292	452	24	carbamazepine	carbamazepine	NOUN
admet-292	452	25	dihydrate	dihydrate	NOUN
admet-292	452	26	,	,	PUNCT
admet-292	452	27	with	with	ADP
admet-292	452	28	a	a	DET
admet-292	452	29	significantly	significantly	ADV
admet-292	452	30	lower	low	ADJ
admet-292	452	31	solubility	solubility	NOUN
admet-292	452	32	,	,	PUNCT
admet-292	452	33	and	and	CCONJ
admet-292	452	34	the	the	DET
admet-292	452	35	concentration	concentration	NOUN
admet-292	452	36	of	of	ADP
admet-292	452	37	carbamazepine	carbamazepine	NOUN
admet-292	452	38	in	in	ADP
admet-292	452	39	solution	solution	NOUN
admet-292	452	40	drops	drop	NOUN
admet-292	452	41	.	.	PUNCT
admet-292	453	1	cocrystal	cocrystal	ADJ
admet-292	453	2	solid	solid	ADJ
admet-292	453	3	-	-	PUNCT
admet-292	453	4	solution	solution	NOUN
admet-292	453	5	equilibria	equilibrium	NOUN
admet-292	453	6	are	be	AUX
admet-292	453	7	dictated	dictate	VERB
admet-292	453	8	by	by	ADP
admet-292	453	9	solution	solution	NOUN
admet-292	453	10	composition	composition	NOUN
admet-292	453	11	.	.	PUNCT
admet-292	454	1	if	if	SCONJ
admet-292	454	2	anhydrous	anhydrous	ADJ
admet-292	454	3	carbamazepine	carbamazepine	NOUN
admet-292	454	4	is	be	AUX
admet-292	454	5	dissolved	dissolve	VERB
admet-292	454	6	in	in	ADP
admet-292	454	7	the	the	DET
admet-292	454	8	solution	solution	NOUN
admet-292	454	9	of	of	ADP
admet-292	454	10	nicotinamide	nicotinamide	NOUN
admet-292	454	11	,	,	PUNCT
admet-292	454	12	a	a	DET
admet-292	454	13	1:1	1:1	NUM
admet-292	454	14	cocrystal	cocrystal	NOUN
admet-292	454	15	is	be	AUX
admet-292	454	16	formed	form	VERB
admet-292	454	17	[	[	X
admet-292	454	18	108	108	NUM
admet-292	454	19	]	]	PUNCT
admet-292	454	20	.	.	PUNCT
admet-292	455	1	figure	figure	NOUN
admet-292	455	2	17	17	NUM
admet-292	455	3	.	.	PUNCT
admet-292	456	1	transformation	transformation	NOUN
admet-292	456	2	of	of	ADP
admet-292	456	3	a	a	DET
admet-292	456	4	cocrystal	cocrystal	NOUN
admet-292	456	5	of	of	ADP
admet-292	456	6	carbamazepine	carbamazepine	NOUN
admet-292	456	7	with	with	ADP
admet-292	456	8	nicotinamide	nicotinamide	NOUN
admet-292	456	9	into	into	ADP
admet-292	456	10	carbamazepine	carbamazepine	NOUN
admet-292	456	11	dihydrate	dihydrate	NOUN
admet-292	456	12	on	on	ADP
admet-292	456	13	dissolution	dissolution	NOUN
admet-292	456	14	(	(	PUNCT
admet-292	456	15	monitored	monitor	VERB
admet-292	456	16	spectroscopically	spectroscopically	ADV
admet-292	456	17	)	)	PUNCT
admet-292	456	18	.	.	PUNCT
admet-292	457	1	data	datum	NOUN
admet-292	457	2	from	from	ADP
admet-292	457	3	[	[	X
admet-292	457	4	108	108	NUM
admet-292	457	5	]	]	PUNCT
admet-292	457	6	.	.	PUNCT
admet-292	458	1	alex	alex	PROPN
admet-292	458	2	avdeef	avdeef	PROPN
admet-292	458	3	et	et	PROPN
admet-292	458	4	al	al	PROPN
admet-292	458	5	.	.	PROPN
admet-292	458	6	admet	admet	PROPN
admet-292	458	7	&	&	CCONJ
admet-292	458	8	dmpk	dmpk	PROPN
admet-292	458	9	4(2	4(2	NUM
admet-292	458	10	)	)	PUNCT
admet-292	458	11	(	(	PUNCT
admet-292	458	12	2016	2016	NUM
admet-292	458	13	)	)	PUNCT
admet-292	458	14	117	117	NUM
admet-292	458	15	-	-	SYM
admet-292	458	16	178	178	NUM
admet-292	458	17	140	140	NUM
admet-292	458	18	cocrystal	cocrystal	ADJ
admet-292	458	19	solubility	solubility	NOUN
admet-292	458	20	-	-	PUNCT
admet-292	458	21	ph	ph	ADJ
admet-292	458	22	profiles	profile	NOUN
admet-292	458	23	cocrystals	cocrystal	NOUN
admet-292	458	24	can	can	AUX
admet-292	458	25	impact	impact	VERB
admet-292	458	26	ph	ph	ADJ
admet-292	458	27	-	-	ADJ
admet-292	458	28	dependent	dependent	ADJ
admet-292	458	29	solubility	solubility	NOUN
admet-292	458	30	even	even	ADV
admet-292	458	31	when	when	SCONJ
admet-292	458	32	the	the	DET
admet-292	458	33	drug	drug	NOUN
admet-292	458	34	is	be	AUX
admet-292	458	35	nonionizable	nonionizable	ADJ
admet-292	458	36	.	.	PUNCT
admet-292	459	1	the	the	DET
admet-292	459	2	ph	ph	ADJ
admet-292	459	3	dependence	dependence	NOUN
admet-292	459	4	of	of	ADP
admet-292	459	5	the	the	DET
admet-292	459	6	solubility	solubility	NOUN
admet-292	459	7	of	of	ADP
admet-292	459	8	a	a	DET
admet-292	459	9	cocrystal	cocrystal	NOUN
admet-292	459	10	can	can	AUX
admet-292	459	11	differ	differ	VERB
admet-292	459	12	significantly	significantly	ADV
admet-292	459	13	from	from	ADP
admet-292	459	14	that	that	PRON
admet-292	459	15	of	of	ADP
admet-292	459	16	a	a	DET
admet-292	459	17	pure	pure	ADJ
admet-292	459	18	drug	drug	NOUN
admet-292	459	19	compound	compound	NOUN
admet-292	459	20	,	,	PUNCT
admet-292	459	21	the	the	DET
admet-292	459	22	curves	curve	NOUN
admet-292	459	23	being	be	AUX
admet-292	459	24	qualitatively	qualitatively	ADV
admet-292	459	25	different	different	ADJ
admet-292	459	26	for	for	ADP
admet-292	459	27	ionizable	ionizable	ADJ
admet-292	459	28	/	/	SYM
admet-292	459	29	non	non	ADJ
admet-292	459	30	-	-	ADJ
admet-292	459	31	ionizable	ionizable	ADJ
admet-292	459	32	/	/	SYM
admet-292	459	33	zwitterionic	zwitterionic	ADJ
admet-292	459	34	api	api	NOUN
admet-292	459	35	and	and	CCONJ
admet-292	459	36	amphoteric	amphoteric	ADJ
admet-292	459	37	/	/	SYM
admet-292	459	38	basic	basic	ADJ
admet-292	459	39	/	/	SYM
admet-292	459	40	acidic	acidic	ADJ
admet-292	459	41	coformer	coformer	NOUN
admet-292	459	42	[	[	X
admet-292	459	43	31	31	NUM
admet-292	459	44	]	]	PUNCT
admet-292	459	45	.	.	PUNCT
admet-292	460	1	figure	figure	NOUN
admet-292	460	2	18	18	NUM
admet-292	460	3	illustrates	illustrate	VERB
admet-292	460	4	this	this	DET
admet-292	460	5	using	use	VERB
admet-292	460	6	as	as	ADP
admet-292	460	7	examples	example	NOUN
admet-292	460	8	the	the	DET
admet-292	460	9	solubility	solubility	NOUN
admet-292	460	10	of	of	ADP
admet-292	460	11	the	the	DET
admet-292	460	12	carbamazepine	carbamazepine	NOUN
admet-292	460	13	–	–	PUNCT
admet-292	460	14	salicylic	salicylic	ADJ
admet-292	460	15	acid	acid	PROPN
admet-292	460	16	1:1	1:1	NUM
admet-292	461	1	cocrystal	cocrystal	PROPN
admet-292	461	2	(	(	PUNCT
admet-292	461	3	figure	figure	NOUN
admet-292	461	4	18a	18a	NOUN
admet-292	461	5	)	)	PUNCT
admet-292	461	6	and	and	CCONJ
admet-292	461	7	of	of	ADP
admet-292	461	8	the	the	DET
admet-292	461	9	carbamazepine-4	carbamazepine-4	NOUN
admet-292	461	10	amino	amino	ADJ
admet-292	461	11	-	-	PUNCT
admet-292	461	12	benzoic	benzoic	NOUN
admet-292	461	13	acid	acid	NOUN
admet-292	461	14	hydrate	hydrate	NOUN
admet-292	461	15	2:1	2:1	NUM
admet-292	461	16	cocrystal	cocrystal	PROPN
admet-292	461	17	(	(	PUNCT
admet-292	461	18	figure	figure	NOUN
admet-292	461	19	18b	18b	NOUN
admet-292	461	20	)	)	PUNCT
admet-292	461	21	as	as	ADP
admet-292	461	22	functions	function	NOUN
admet-292	461	23	of	of	ADP
admet-292	461	24	ph	ph	NOUN
admet-292	461	25	,	,	PUNCT
admet-292	461	26	and	and	CCONJ
admet-292	461	27	,	,	PUNCT
admet-292	461	28	for	for	ADP
admet-292	461	29	a	a	DET
admet-292	461	30	comparison	comparison	NOUN
admet-292	461	31	,	,	PUNCT
admet-292	461	32	the	the	DET
admet-292	461	33	ph	ph	ADJ
admet-292	461	34	independence	independence	NOUN
admet-292	461	35	of	of	ADP
admet-292	461	36	the	the	DET
admet-292	461	37	solubility	solubility	NOUN
admet-292	461	38	of	of	ADP
admet-292	461	39	the	the	DET
admet-292	461	40	pure	pure	ADJ
admet-292	461	41	drugs	drug	NOUN
admet-292	461	42	[	[	X
admet-292	461	43	31	31	NUM
admet-292	461	44	]	]	PUNCT
admet-292	461	45	.	.	PUNCT
admet-292	462	1	figure	figure	NOUN
admet-292	462	2	18	18	NUM
admet-292	462	3	.	.	PUNCT
admet-292	463	1	(	(	PUNCT
admet-292	463	2	a	a	X
admet-292	463	3	)	)	PUNCT
admet-292	463	4	the	the	DET
admet-292	463	5	solubility	solubility	NOUN
admet-292	463	6	of	of	ADP
admet-292	463	7	the	the	DET
admet-292	463	8	carbamazepine	carbamazepine	NOUN
admet-292	463	9	–	–	PUNCT
admet-292	463	10	salicylic	salicylic	ADJ
admet-292	463	11	acid	acid	PROPN
admet-292	463	12	1:1	1:1	NUM
admet-292	463	13	cocrystal	cocrystal	PROPN
admet-292	463	14	,	,	PUNCT
admet-292	463	15	and	and	CCONJ
admet-292	463	16	(	(	PUNCT
admet-292	463	17	b	b	X
admet-292	463	18	)	)	PUNCT
admet-292	463	19	the	the	DET
admet-292	463	20	solubility	solubility	NOUN
admet-292	463	21	of	of	ADP
admet-292	463	22	the	the	DET
admet-292	463	23	carbamazepine	carbamazepine	NOUN
admet-292	463	24	4	4	NUM
admet-292	463	25	-	-	PUNCT
admet-292	463	26	aminobenzoic	aminobenzoic	ADJ
admet-292	463	27	acid	acid	NOUN
admet-292	463	28	hydrate	hydrate	NOUN
admet-292	463	29	2:1	2:1	NUM
admet-292	463	30	cocrystal	cocrystal	NOUN
admet-292	463	31	as	as	ADP
admet-292	463	32	functions	function	NOUN
admet-292	463	33	of	of	ADP
admet-292	463	34	ph	ph	NOUN
admet-292	463	35	.	.	PUNCT
admet-292	464	1	the	the	DET
admet-292	464	2	dashed	dash	VERB
admet-292	464	3	lines	line	NOUN
admet-292	464	4	are	be	AUX
admet-292	464	5	the	the	DET
admet-292	464	6	expected	expect	VERB
admet-292	464	7	solubilities	solubility	NOUN
admet-292	464	8	of	of	ADP
admet-292	464	9	the	the	DET
admet-292	464	10	pure	pure	ADJ
admet-292	464	11	drugs	drug	NOUN
admet-292	464	12	[	[	X
admet-292	464	13	31	31	NUM
admet-292	464	14	]	]	PUNCT
admet-292	464	15	.	.	PUNCT
admet-292	465	1	the	the	DET
admet-292	465	2	data	datum	NOUN
admet-292	465	3	from	from	ADP
admet-292	465	4	[	[	X
admet-292	465	5	31	31	NUM
admet-292	465	6	]	]	PUNCT
admet-292	465	7	have	have	AUX
admet-292	465	8	been	be	AUX
admet-292	465	9	processed	process	VERB
admet-292	465	10	using	use	VERB
admet-292	465	11	pdisol	pdisol	NOUN
admet-292	465	12	-	-	PUNCT
admet-292	465	13	x.	x.	NOUN
admet-292	465	14	the	the	DET
admet-292	465	15	data	datum	NOUN
admet-292	465	16	from	from	ADP
admet-292	465	17	bethune	bethune	PROPN
admet-292	465	18	et	et	PROPN
admet-292	465	19	al	al	PROPN
admet-292	465	20	.	.	PUNCT
admet-292	466	1	[	[	X
admet-292	466	2	31	31	NUM
admet-292	466	3	]	]	PUNCT
admet-292	466	4	have	have	AUX
admet-292	466	5	been	be	AUX
admet-292	466	6	processed	process	VERB
admet-292	466	7	using	use	VERB
admet-292	466	8	pdisol	pdisol	NOUN
admet-292	466	9	-	-	PUNCT
admet-292	466	10	x.	x.	NOUN
admet-292	466	11	this	this	DET
admet-292	466	12	procedure	procedure	NOUN
admet-292	466	13	has	have	AUX
admet-292	466	14	given	give	VERB
admet-292	466	15	almost	almost	ADV
admet-292	466	16	the	the	DET
admet-292	466	17	same	same	ADJ
admet-292	466	18	ksp	ksp	PROPN
admet-292	466	19	value	value	NOUN
admet-292	466	20	for	for	ADP
admet-292	466	21	the	the	DET
admet-292	466	22	carbamazepine	carbamazepine	NOUN
admet-292	466	23	–	–	PUNCT
admet-292	466	24	salicylic	salicylic	ADJ
admet-292	466	25	acid	acid	PROPN
admet-292	466	26	1:1	1:1	NUM
admet-292	466	27	cocrystal	cocrystal	PROPN
admet-292	466	28	as	as	SCONJ
admet-292	466	29	reported	report	VERB
admet-292	466	30	in	in	ADP
admet-292	466	31	[	[	X
admet-292	466	32	31	31	NUM
admet-292	466	33	]	]	PUNCT
admet-292	466	34	,	,	PUNCT
admet-292	466	35	but	but	CCONJ
admet-292	466	36	it	it	PRON
admet-292	466	37	was	be	AUX
admet-292	466	38	necessary	necessary	ADJ
admet-292	466	39	to	to	PART
admet-292	466	40	introduce	introduce	VERB
admet-292	466	41	a	a	DET
admet-292	466	42	complex	complex	NOUN
admet-292	466	43	between	between	ADP
admet-292	466	44	carbamazepine	carbamazepine	NOUN
admet-292	466	45	and	and	CCONJ
admet-292	466	46	salicylate	salicylate	NOUN
admet-292	466	47	anion	anion	NOUN
admet-292	466	48	.	.	PUNCT
admet-292	467	1	to	to	PART
admet-292	467	2	interpret	interpret	VERB
admet-292	467	3	the	the	DET
admet-292	467	4	curve	curve	NOUN
admet-292	467	5	with	with	ADP
admet-292	467	6	the	the	DET
admet-292	467	7	minimum	minimum	NOUN
admet-292	467	8	for	for	ADP
admet-292	467	9	the	the	DET
admet-292	467	10	carbamazepine	carbamazepine	NOUN
admet-292	467	11	–	–	PUNCT
admet-292	467	12	4	4	NUM
admet-292	467	13	-	-	PUNCT
admet-292	467	14	aminobenzoic	aminobenzoic	ADJ
admet-292	467	15	acid	acid	NOUN
admet-292	467	16	hydrate	hydrate	NOUN
admet-292	467	17	2:1	2:1	NUM
admet-292	467	18	cocrystal	cocrystal	PROPN
admet-292	467	19	,	,	PUNCT
admet-292	467	20	one	one	PRON
admet-292	467	21	needs	need	VERB
admet-292	467	22	to	to	PART
admet-292	467	23	consider	consider	VERB
admet-292	467	24	cocrystal	cocrystal	ADJ
admet-292	467	25	dissociation	dissociation	NOUN
admet-292	467	26	and	and	CCONJ
admet-292	467	27	coformer	coformer	NOUN
admet-292	467	28	ionization	ionization	NOUN
admet-292	467	29	.	.	PUNCT
admet-292	468	1	admet	admet	PROPN
admet-292	468	2	&	&	CCONJ
admet-292	468	3	dmpk	dmpk	PROPN
admet-292	468	4	4(2	4(2	NUM
admet-292	468	5	)	)	PUNCT
admet-292	468	6	(	(	PUNCT
admet-292	468	7	2016	2016	NUM
admet-292	468	8	)	)	PUNCT
admet-292	468	9	117	117	NUM
admet-292	468	10	-	-	SYM
admet-292	468	11	178	178	NUM
admet-292	468	12	consensus	consensus	NOUN
admet-292	468	13	recommendations	recommendation	NOUN
admet-292	468	14	for	for	ADP
admet-292	468	15	improving	improve	VERB
admet-292	468	16	solubility	solubility	NOUN
admet-292	468	17	-	-	PUNCT
admet-292	468	18	ph	ph	ADJ
admet-292	468	19	data	datum	NOUN
admet-292	468	20	quality	quality	NOUN
admet-292	468	21	doi	doi	NOUN
admet-292	468	22	:	:	PUNCT
admet-292	468	23	10.5599	10.5599	NUM
admet-292	468	24	/	/	SYM
admet-292	468	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	468	26	141	141	NUM
admet-292	468	27	analysis	analysis	NOUN
admet-292	468	28	of	of	ADP
admet-292	468	29	the	the	DET
admet-292	468	30	species	specie	NOUN
admet-292	468	31	in	in	ADP
admet-292	468	32	the	the	DET
admet-292	468	33	saturated	saturate	VERB
admet-292	468	34	solution	solution	NOUN
admet-292	468	35	using	use	VERB
admet-292	468	36	mass	mass	ADJ
admet-292	468	37	spectrometry	spectrometry	NOUN
admet-292	468	38	mass	mass	NOUN
admet-292	468	39	spectrometry	spectrometry	NOUN
admet-292	468	40	is	be	AUX
admet-292	468	41	a	a	DET
admet-292	468	42	powerful	powerful	ADJ
admet-292	468	43	technique	technique	NOUN
admet-292	468	44	to	to	PART
admet-292	468	45	obtain	obtain	VERB
admet-292	468	46	information	information	NOUN
admet-292	468	47	about	about	ADP
admet-292	468	48	the	the	DET
admet-292	468	49	species	specie	NOUN
admet-292	468	50	present	present	ADJ
admet-292	468	51	in	in	ADP
admet-292	468	52	any	any	DET
admet-292	468	53	solution	solution	NOUN
admet-292	468	54	,	,	PUNCT
admet-292	468	55	including	include	VERB
admet-292	468	56	saturated	saturate	VERB
admet-292	468	57	solutions	solution	NOUN
admet-292	468	58	[	[	X
admet-292	468	59	53	53	NUM
admet-292	468	60	]	]	PUNCT
admet-292	468	61	.	.	PUNCT
admet-292	469	1	in	in	ADP
admet-292	469	2	solubility	solubility	NOUN
admet-292	469	3	assays	assay	NOUN
admet-292	469	4	,	,	PUNCT
admet-292	469	5	apart	apart	ADV
admet-292	469	6	from	from	ADP
admet-292	469	7	the	the	DET
admet-292	469	8	compound	compound	NOUN
admet-292	469	9	itself	itself	PRON
admet-292	469	10	,	,	PUNCT
admet-292	469	11	the	the	DET
admet-292	469	12	presence	presence	NOUN
admet-292	469	13	of	of	ADP
admet-292	469	14	charged	charge	VERB
admet-292	469	15	aggregates	aggregate	NOUN
admet-292	469	16	can	can	AUX
admet-292	469	17	be	be	AUX
admet-292	469	18	detected	detect	VERB
admet-292	469	19	by	by	ADP
admet-292	469	20	direct	direct	ADJ
admet-292	469	21	infusion	infusion	NOUN
admet-292	469	22	into	into	ADP
admet-292	469	23	the	the	DET
admet-292	469	24	mass	mass	ADJ
admet-292	469	25	spectrometer	spectrometer	NOUN
admet-292	469	26	of	of	ADP
admet-292	469	27	the	the	DET
admet-292	469	28	saturated	saturate	VERB
admet-292	469	29	solution	solution	NOUN
admet-292	469	30	,	,	PUNCT
admet-292	469	31	as	as	SCONJ
admet-292	469	32	demonstrated	demonstrate	VERB
admet-292	469	33	for	for	ADP
admet-292	469	34	cefadroxyl	cefadroxyl	NOUN
admet-292	469	35	by	by	ADP
admet-292	469	36	shoghi	shoghi	X
admet-292	469	37	et	et	PROPN
admet-292	469	38	al	al	PROPN
admet-292	469	39	.	.	PUNCT
admet-292	470	1	[	[	X
admet-292	470	2	53	53	NUM
admet-292	470	3	]	]	PUNCT
admet-292	470	4	(	(	PUNCT
admet-292	470	5	cf	cf	NOUN
admet-292	470	6	.	.	PUNCT
admet-292	470	7	,	,	PUNCT
admet-292	470	8	figure	figure	NOUN
admet-292	470	9	2a	2a	NUM
admet-292	470	10	)	)	PUNCT
admet-292	470	11	.	.	PUNCT
admet-292	471	1	with	with	ADP
admet-292	471	2	a	a	DET
admet-292	471	3	simple	simple	ADJ
admet-292	471	4	mass	mass	NOUN
admet-292	471	5	spectrometer	spectrometer	NOUN
admet-292	471	6	(	(	PUNCT
admet-292	471	7	i.e.	i.e.	X
admet-292	471	8	,	,	PUNCT
admet-292	471	9	an	an	DET
admet-292	471	10	electrospray	electrospray	NOUN
admet-292	471	11	ionization	ionization	NOUN
admet-292	471	12	source	source	NOUN
admet-292	471	13	and	and	CCONJ
admet-292	471	14	a	a	DET
admet-292	471	15	single	single	ADJ
admet-292	471	16	quadrupole	quadrupole	NOUN
admet-292	471	17	)	)	PUNCT
admet-292	471	18	aggregates	aggregate	NOUN
admet-292	471	19	with	with	ADP
admet-292	471	20	a	a	DET
admet-292	471	21	molecular	molecular	ADJ
admet-292	471	22	mass	mass	NOUN
admet-292	471	23	up	up	ADP
admet-292	471	24	to	to	PART
admet-292	471	25	1500	1500	NUM
admet-292	471	26	-	-	SYM
admet-292	471	27	2000	2000	NUM
admet-292	471	28	da	da	NOUN
admet-292	471	29	can	can	AUX
admet-292	471	30	be	be	AUX
admet-292	471	31	easily	easily	ADV
admet-292	471	32	observed	observe	VERB
admet-292	471	33	.	.	PUNCT
admet-292	472	1	in	in	ADP
admet-292	472	2	addition	addition	NOUN
admet-292	472	3	,	,	PUNCT
admet-292	472	4	the	the	DET
admet-292	472	5	use	use	NOUN
admet-292	472	6	of	of	ADP
admet-292	472	7	more	more	ADV
admet-292	472	8	sophisticated	sophisticated	ADJ
admet-292	472	9	instruments	instrument	NOUN
admet-292	472	10	,	,	PUNCT
admet-292	472	11	like	like	ADP
admet-292	472	12	triple	triple	ADJ
admet-292	472	13	quadrupoles	quadrupole	NOUN
admet-292	472	14	or	or	CCONJ
admet-292	472	15	highresolution	highresolution	NOUN
admet-292	472	16	mass	mass	NOUN
admet-292	472	17	spectrometers	spectrometer	NOUN
admet-292	472	18	allows	allow	VERB
admet-292	472	19	the	the	DET
admet-292	472	20	confirmation	confirmation	NOUN
admet-292	472	21	of	of	ADP
admet-292	472	22	the	the	DET
admet-292	472	23	presence	presence	NOUN
admet-292	472	24	of	of	ADP
admet-292	472	25	aggregates	aggregate	NOUN
admet-292	472	26	through	through	ADP
admet-292	472	27	the	the	DET
admet-292	472	28	product	product	NOUN
admet-292	472	29	ion	ion	NOUN
admet-292	472	30	scan	scan	NOUN
admet-292	472	31	or	or	CCONJ
admet-292	472	32	the	the	DET
admet-292	472	33	exact	exact	ADJ
admet-292	472	34	mass	mass	NOUN
admet-292	472	35	measurement	measurement	NOUN
admet-292	472	36	of	of	ADP
admet-292	472	37	the	the	DET
admet-292	472	38	aggregates	aggregate	NOUN
admet-292	472	39	.	.	PUNCT
admet-292	473	1	one	one	NUM
admet-292	473	2	important	important	ADJ
admet-292	473	3	requirement	requirement	NOUN
admet-292	473	4	in	in	ADP
admet-292	473	5	the	the	DET
admet-292	473	6	measurements	measurement	NOUN
admet-292	473	7	when	when	SCONJ
admet-292	473	8	buffered	buffered	ADJ
admet-292	473	9	solutions	solution	NOUN
admet-292	473	10	are	be	AUX
admet-292	473	11	used	use	VERB
admet-292	473	12	is	be	AUX
admet-292	473	13	that	that	SCONJ
admet-292	473	14	buffers	buffer	NOUN
admet-292	473	15	must	must	AUX
admet-292	473	16	be	be	AUX
admet-292	473	17	ms	ms	NOUN
admet-292	473	18	compatible	compatible	ADJ
admet-292	473	19	.	.	PUNCT
admet-292	474	1	thus	thus	ADV
admet-292	474	2	,	,	PUNCT
admet-292	474	3	buffers	buffer	NOUN
admet-292	474	4	based	base	VERB
admet-292	474	5	on	on	ADP
admet-292	474	6	compounds	compound	NOUN
admet-292	474	7	such	such	ADJ
admet-292	474	8	as	as	ADP
admet-292	474	9	formic	formic	ADJ
admet-292	474	10	acid	acid	NOUN
admet-292	474	11	,	,	PUNCT
admet-292	474	12	acetic	acetic	ADJ
admet-292	474	13	acid	acid	NOUN
admet-292	474	14	,	,	PUNCT
admet-292	474	15	lactic	lactic	ADJ
admet-292	474	16	acid	acid	NOUN
admet-292	474	17	,	,	PUNCT
admet-292	474	18	carbonic	carbonic	ADJ
admet-292	474	19	acid	acid	NOUN
admet-292	474	20	,	,	PUNCT
admet-292	474	21	ammonia	ammonia	NOUN
admet-292	474	22	,	,	PUNCT
admet-292	474	23	or	or	CCONJ
admet-292	474	24	ethylenediamine	ethylenediamine	NOUN
admet-292	474	25	are	be	AUX
admet-292	474	26	recommended	recommend	VERB
admet-292	474	27	.	.	PUNCT
admet-292	475	1	it	it	PRON
admet-292	475	2	is	be	AUX
admet-292	475	3	helpful	helpful	ADJ
admet-292	475	4	to	to	PART
admet-292	475	5	report	report	VERB
admet-292	475	6	buffer	buffer	NOUN
admet-292	475	7	concentrations	concentration	NOUN
admet-292	475	8	in	in	ADP
admet-292	475	9	mm	mm	PROPN
admet-292	475	10	units	unit	NOUN
admet-292	475	11	.	.	PUNCT
admet-292	476	1	another	another	DET
admet-292	476	2	compulsory	compulsory	ADJ
admet-292	476	3	caution	caution	NOUN
admet-292	476	4	is	be	AUX
admet-292	476	5	to	to	PART
admet-292	476	6	avoid	avoid	VERB
admet-292	476	7	the	the	DET
admet-292	476	8	formation	formation	NOUN
admet-292	476	9	of	of	ADP
admet-292	476	10	aggregates	aggregate	NOUN
admet-292	476	11	in	in	ADP
admet-292	476	12	the	the	DET
admet-292	476	13	ionization	ionization	NOUN
admet-292	476	14	source	source	NOUN
admet-292	476	15	.	.	PUNCT
admet-292	477	1	this	this	DET
admet-292	477	2	drawback	drawback	NOUN
admet-292	477	3	can	can	AUX
admet-292	477	4	be	be	AUX
admet-292	477	5	easily	easily	ADV
admet-292	477	6	overcome	overcome	VERB
admet-292	477	7	by	by	ADP
admet-292	477	8	raising	raise	VERB
admet-292	477	9	the	the	DET
admet-292	477	10	declustering	declustere	VERB
admet-292	477	11	potential	potential	NOUN
admet-292	477	12	of	of	ADP
admet-292	477	13	the	the	DET
admet-292	477	14	source	source	NOUN
admet-292	477	15	to	to	ADP
admet-292	477	16	high	high	ADJ
admet-292	477	17	voltages	voltage	NOUN
admet-292	477	18	(	(	PUNCT
admet-292	477	19	up	up	ADP
admet-292	477	20	to	to	ADP
admet-292	477	21	±	±	NUM
admet-292	477	22	200v	200v	NOUN
admet-292	477	23	,	,	PUNCT
admet-292	477	24	depending	depend	VERB
admet-292	477	25	on	on	ADP
admet-292	477	26	the	the	DET
admet-292	477	27	ionization	ionization	NOUN
admet-292	477	28	mode	mode	NOUN
admet-292	477	29	)	)	PUNCT
admet-292	477	30	.	.	PUNCT
admet-292	478	1	under	under	ADP
admet-292	478	2	such	such	ADJ
admet-292	478	3	conditions	condition	NOUN
admet-292	478	4	,	,	PUNCT
admet-292	478	5	much	much	ADV
admet-292	478	6	more	more	ADJ
admet-292	478	7	fragmentation	fragmentation	NOUN
admet-292	478	8	is	be	AUX
admet-292	478	9	observed	observe	VERB
admet-292	478	10	,	,	PUNCT
admet-292	478	11	but	but	CCONJ
admet-292	478	12	in	in	ADP
admet-292	478	13	case	case	NOUN
admet-292	478	14	aggregates	aggregate	NOUN
admet-292	478	15	are	be	AUX
admet-292	478	16	detected	detect	VERB
admet-292	478	17	it	it	PRON
admet-292	478	18	is	be	AUX
admet-292	478	19	ensured	ensure	VERB
admet-292	478	20	that	that	SCONJ
admet-292	478	21	they	they	PRON
admet-292	478	22	come	come	VERB
admet-292	478	23	uniquely	uniquely	ADV
admet-292	478	24	from	from	ADP
admet-292	478	25	the	the	DET
admet-292	478	26	sample	sample	NOUN
admet-292	478	27	itself	itself	PRON
admet-292	478	28	.	.	PUNCT
admet-292	479	1	recommendation	recommendation	NOUN
admet-292	479	2	for	for	ADP
admet-292	479	3	solid	solid	ADJ
admet-292	479	4	state	state	NOUN
admet-292	479	5	characterization	characterization	NOUN
admet-292	479	6	it	it	PRON
admet-292	479	7	is	be	AUX
admet-292	479	8	recommended	recommend	VERB
admet-292	479	9	that	that	SCONJ
admet-292	479	10	the	the	DET
admet-292	479	11	solid	solid	ADJ
admet-292	479	12	sample	sample	NOUN
admet-292	479	13	for	for	ADP
admet-292	479	14	which	which	PRON
admet-292	479	15	solubility	solubility	NOUN
admet-292	479	16	is	be	AUX
admet-292	479	17	measured	measure	VERB
admet-292	479	18	be	be	AUX
admet-292	479	19	evaluated	evaluate	VERB
admet-292	479	20	by	by	ADP
admet-292	479	21	powder	powder	NOUN
admet-292	479	22	x	x	NOUN
admet-292	479	23	-	-	NOUN
admet-292	479	24	ray	ray	NOUN
admet-292	479	25	diffraction	diffraction	NOUN
admet-292	479	26	(	(	PUNCT
admet-292	479	27	pxrd	pxrd	PROPN
admet-292	479	28	)	)	PUNCT
admet-292	479	29	,	,	PUNCT
admet-292	479	30	both	both	CCONJ
admet-292	479	31	before	before	ADP
admet-292	479	32	and	and	CCONJ
admet-292	479	33	after	after	SCONJ
admet-292	479	34	the	the	DET
admet-292	479	35	solubility	solubility	NOUN
admet-292	479	36	assay	assay	VERB
admet-292	479	37	.	.	PUNCT
admet-292	480	1	if	if	SCONJ
admet-292	480	2	possible	possible	ADJ
admet-292	480	3	,	,	PUNCT
admet-292	480	4	it	it	PRON
admet-292	480	5	is	be	AUX
admet-292	480	6	preferable	preferable	ADJ
admet-292	480	7	to	to	PART
admet-292	480	8	monitor	monitor	VERB
admet-292	480	9	the	the	DET
admet-292	480	10	sample	sample	NOUN
admet-292	480	11	directly	directly	ADV
admet-292	480	12	in	in	ADP
admet-292	480	13	solution	solution	NOUN
admet-292	480	14	(	(	PUNCT
admet-292	480	15	modern	modern	ADJ
admet-292	480	16	pxrd	pxrd	NOUN
admet-292	480	17	instruments	instrument	NOUN
admet-292	480	18	specially	specially	ADV
admet-292	480	19	adapted	adapt	VERB
admet-292	480	20	for	for	ADP
admet-292	480	21	the	the	DET
admet-292	480	22	needs	need	NOUN
admet-292	480	23	of	of	ADP
admet-292	480	24	pharmaceutical	pharmaceutical	NOUN
admet-292	480	25	industry	industry	NOUN
admet-292	480	26	make	make	VERB
admet-292	480	27	this	this	PRON
admet-292	480	28	possible	possible	ADJ
admet-292	480	29	)	)	PUNCT
admet-292	480	30	.	.	PUNCT
admet-292	481	1	if	if	SCONJ
admet-292	481	2	,	,	PUNCT
admet-292	481	3	however	however	ADV
admet-292	481	4	,	,	PUNCT
admet-292	481	5	such	such	DET
admet-292	481	6	an	an	DET
admet-292	481	7	in	in	ADP
admet-292	481	8	situ	situ	ADJ
admet-292	481	9	measurement	measurement	NOUN
admet-292	481	10	is	be	AUX
admet-292	481	11	not	not	PART
admet-292	481	12	possible	possible	ADJ
admet-292	481	13	,	,	PUNCT
admet-292	481	14	the	the	DET
admet-292	481	15	conditions	condition	NOUN
admet-292	481	16	of	of	ADP
admet-292	481	17	separating	separate	VERB
admet-292	481	18	the	the	DET
admet-292	481	19	solid	solid	ADJ
admet-292	481	20	from	from	ADP
admet-292	481	21	solution	solution	NOUN
admet-292	481	22	,	,	PUNCT
admet-292	481	23	drying	dry	VERB
admet-292	481	24	and	and	CCONJ
admet-292	481	25	preparing	prepare	VERB
admet-292	481	26	the	the	DET
admet-292	481	27	sample	sample	NOUN
admet-292	481	28	for	for	ADP
admet-292	481	29	pxrd	pxrd	NOUN
admet-292	481	30	(	(	PUNCT
admet-292	481	31	e.g.	e.g.	ADV
admet-292	481	32	,	,	PUNCT
admet-292	481	33	manual	manual	NOUN
admet-292	481	34	grinding	grind	VERB
admet-292	481	35	in	in	ADP
admet-292	481	36	a	a	DET
admet-292	481	37	mortar	mortar	NOUN
admet-292	481	38	)	)	PUNCT
admet-292	481	39	must	must	AUX
admet-292	481	40	be	be	AUX
admet-292	481	41	specified	specify	VERB
admet-292	481	42	and	and	CCONJ
admet-292	481	43	standardized	standardize	VERB
admet-292	481	44	with	with	ADP
admet-292	481	45	utmost	utmost	ADJ
admet-292	481	46	care	care	NOUN
admet-292	481	47	.	.	PUNCT
admet-292	482	1	quite	quite	ADV
admet-292	482	2	often	often	ADV
admet-292	482	3	,	,	PUNCT
admet-292	482	4	phase	phase	NOUN
admet-292	482	5	transition	transition	NOUN
admet-292	482	6	,	,	PUNCT
admet-292	482	7	dehydration	dehydration	NOUN
admet-292	482	8	,	,	PUNCT
admet-292	482	9	or	or	CCONJ
admet-292	482	10	transformation	transformation	NOUN
admet-292	482	11	(	(	PUNCT
admet-292	482	12	in	in	ADP
admet-292	482	13	a	a	DET
admet-292	482	14	multi	multi	ADJ
admet-292	482	15	-	-	ADJ
admet-292	482	16	component	component	ADJ
admet-292	482	17	system	system	NOUN
admet-292	482	18	)	)	PUNCT
admet-292	482	19	can	can	AUX
admet-292	482	20	occur	occur	VERB
admet-292	482	21	on	on	ADP
admet-292	482	22	drying	dry	VERB
admet-292	482	23	,	,	PUNCT
admet-292	482	24	grinding	grinding	NOUN
admet-292	482	25	,	,	PUNCT
admet-292	482	26	tableting	tableting	NOUN
admet-292	482	27	,	,	PUNCT
admet-292	482	28	or	or	CCONJ
admet-292	482	29	storage	storage	NOUN
admet-292	482	30	.	.	PUNCT
admet-292	483	1	it	it	PRON
admet-292	483	2	is	be	AUX
admet-292	483	3	recommended	recommend	VERB
admet-292	483	4	that	that	SCONJ
admet-292	483	5	the	the	DET
admet-292	483	6	pxrd	pxrd	NOUN
admet-292	483	7	pattern	pattern	NOUN
admet-292	483	8	be	be	AUX
admet-292	483	9	measured	measure	VERB
admet-292	483	10	in	in	ADP
admet-292	483	11	a	a	DET
admet-292	483	12	broad	broad	ADJ
admet-292	483	13	enough	enough	ADJ
admet-292	483	14	range	range	NOUN
admet-292	483	15	of	of	ADP
admet-292	483	16	2	2	NUM
admet-292	483	17	diffraction	diffraction	NOUN
admet-292	483	18	angles	angle	NOUN
admet-292	483	19	and	and	CCONJ
admet-292	483	20	analyzed	analyze	VERB
admet-292	483	21	as	as	ADP
admet-292	483	22	a	a	DET
admet-292	483	23	whole	whole	NOUN
admet-292	483	24	,	,	PUNCT
admet-292	483	25	not	not	PART
admet-292	483	26	just	just	ADV
admet-292	483	27	by	by	ADP
admet-292	483	28	searching	search	VERB
admet-292	483	29	selected	select	VERB
admet-292	483	30	peaks	peak	NOUN
admet-292	483	31	,	,	PUNCT
admet-292	483	32	and	and	CCONJ
admet-292	483	33	where	where	SCONJ
admet-292	483	34	possible	possible	ADJ
admet-292	483	35	samples	sample	NOUN
admet-292	483	36	should	should	AUX
admet-292	483	37	be	be	AUX
admet-292	483	38	loaded	load	VERB
admet-292	483	39	in	in	ADP
admet-292	483	40	capillaries	capillary	NOUN
admet-292	483	41	for	for	ADP
admet-292	483	42	data	datum	NOUN
admet-292	483	43	collection	collection	NOUN
admet-292	483	44	so	so	SCONJ
admet-292	483	45	we	we	PRON
admet-292	483	46	minimize	minimize	VERB
admet-292	483	47	preferred	preferred	ADJ
admet-292	483	48	orientation	orientation	NOUN
admet-292	483	49	peaks	peak	NOUN
admet-292	483	50	.	.	PUNCT
admet-292	484	1	confocal	confocal	ADJ
admet-292	484	2	raman	raman	NOUN
admet-292	484	3	spectroscopy	spectroscopy	NOUN
admet-292	484	4	can	can	AUX
admet-292	484	5	be	be	AUX
admet-292	484	6	recommended	recommend	VERB
admet-292	484	7	as	as	ADP
admet-292	484	8	a	a	DET
admet-292	484	9	complementary	complementary	ADJ
admet-292	484	10	–	–	PUNCT
admet-292	484	11	though	though	SCONJ
admet-292	484	12	less	less	ADV
admet-292	484	13	unambiguous	unambiguous	ADJ
admet-292	484	14	–	–	PUNCT
admet-292	484	15	tool	tool	NOUN
admet-292	484	16	to	to	PART
admet-292	484	17	control	control	VERB
admet-292	484	18	possible	possible	ADJ
admet-292	484	19	changes	change	NOUN
admet-292	484	20	in	in	ADP
admet-292	484	21	the	the	DET
admet-292	484	22	phase	phase	NOUN
admet-292	484	23	and	and	CCONJ
admet-292	484	24	chemical	chemical	NOUN
admet-292	484	25	composition	composition	NOUN
admet-292	484	26	of	of	ADP
admet-292	484	27	the	the	DET
admet-292	484	28	solid	solid	ADJ
admet-292	484	29	phase	phase	NOUN
admet-292	484	30	.	.	PUNCT
admet-292	485	1	dsc	dsc	NOUN
admet-292	485	2	and	and	CCONJ
admet-292	485	3	tga	tga	NOUN
admet-292	485	4	analysis	analysis	NOUN
admet-292	485	5	of	of	ADP
admet-292	485	6	the	the	DET
admet-292	485	7	sample	sample	NOUN
admet-292	485	8	is	be	AUX
admet-292	485	9	recommended	recommend	VERB
admet-292	485	10	before	before	ADP
admet-292	485	11	and	and	CCONJ
admet-292	485	12	after	after	ADP
admet-292	485	13	the	the	DET
admet-292	485	14	experiment	experiment	NOUN
admet-292	485	15	.	.	PUNCT
admet-292	486	1	note	note	NOUN
admet-292	486	2	,	,	PUNCT
admet-292	486	3	that	that	SCONJ
admet-292	486	4	even	even	ADV
admet-292	486	5	very	very	ADV
admet-292	486	6	similar	similar	ADJ
admet-292	486	7	dsc	dsc	NOUN
admet-292	486	8	curves	curve	NOUN
admet-292	486	9	can	can	AUX
admet-292	486	10	not	not	PART
admet-292	486	11	completely	completely	ADV
admet-292	486	12	exclude	exclude	VERB
admet-292	486	13	that	that	SCONJ
admet-292	486	14	the	the	DET
admet-292	486	15	samples	sample	NOUN
admet-292	486	16	have	have	VERB
admet-292	486	17	different	different	ADJ
admet-292	486	18	phase	phase	NOUN
admet-292	486	19	composition	composition	NOUN
admet-292	486	20	.	.	PUNCT
admet-292	487	1	analysis	analysis	NOUN
admet-292	487	2	of	of	ADP
admet-292	487	3	the	the	DET
admet-292	487	4	final	final	ADJ
admet-292	487	5	solid	solid	ADJ
admet-292	487	6	phase	phase	NOUN
admet-292	487	7	is	be	AUX
admet-292	487	8	desirable	desirable	ADJ
admet-292	487	9	in	in	ADP
admet-292	487	10	all	all	DET
admet-292	487	11	cases	case	NOUN
admet-292	487	12	,	,	PUNCT
admet-292	487	13	since	since	SCONJ
admet-292	487	14	the	the	DET
admet-292	487	15	form	form	NOUN
admet-292	487	16	precipitating	precipitating	NOUN
admet-292	487	17	can	can	AUX
admet-292	487	18	be	be	AUX
admet-292	487	19	,	,	PUNCT
admet-292	487	20	and	and	CCONJ
admet-292	487	21	usually	usually	ADV
admet-292	487	22	is	be	AUX
admet-292	487	23	,	,	PUNCT
admet-292	487	24	different	different	ADJ
admet-292	487	25	from	from	ADP
admet-292	487	26	the	the	DET
admet-292	487	27	form	form	NOUN
admet-292	487	28	introduced	introduce	VERB
admet-292	487	29	at	at	ADP
admet-292	487	30	the	the	DET
admet-292	487	31	beginning	beginning	NOUN
admet-292	487	32	of	of	ADP
admet-292	487	33	the	the	DET
admet-292	487	34	study	study	NOUN
admet-292	487	35	,	,	PUNCT
admet-292	487	36	and	and	CCONJ
admet-292	487	37	becomes	become	VERB
admet-292	487	38	critical	critical	ADJ
admet-292	487	39	if	if	SCONJ
admet-292	487	40	some	some	DET
admet-292	487	41	“	"	PUNCT
admet-292	487	42	anomalies	anomaly	NOUN
admet-292	487	43	”	"	PUNCT
admet-292	487	44	in	in	ADP
admet-292	487	45	the	the	DET
admet-292	487	46	solubility	solubility	NOUN
admet-292	487	47	-	-	PUNCT
admet-292	487	48	ph	ph	VERB
admet-292	487	49	/	/	SYM
admet-292	487	50	time	time	NOUN
admet-292	487	51	profile	profile	NOUN
admet-292	487	52	are	be	AUX
admet-292	487	53	observed	observe	VERB
admet-292	487	54	.	.	PUNCT
admet-292	488	1	careful	careful	ADJ
admet-292	488	2	data	datum	NOUN
admet-292	488	3	processing	processing	NOUN
admet-292	488	4	can	can	AUX
admet-292	488	5	give	give	VERB
admet-292	488	6	insights	insight	NOUN
admet-292	488	7	in	in	ADP
admet-292	488	8	potential	potential	ADJ
admet-292	488	9	changes	change	NOUN
admet-292	488	10	in	in	ADP
admet-292	488	11	the	the	DET
admet-292	488	12	phase	phase	NOUN
admet-292	488	13	composition	composition	NOUN
admet-292	488	14	during	during	ADP
admet-292	488	15	the	the	DET
admet-292	488	16	solubility	solubility	NOUN
admet-292	488	17	measurement	measurement	NOUN
admet-292	488	18	,	,	PUNCT
admet-292	488	19	and	and	CCONJ
admet-292	488	20	also	also	ADV
admet-292	488	21	in	in	ADP
admet-292	488	22	the	the	DET
admet-292	488	23	solid	solid	ADJ
admet-292	488	24	state	state	NOUN
admet-292	488	25	.	.	PUNCT
admet-292	489	1	the	the	DET
admet-292	489	2	latter	latter	ADJ
admet-292	489	3	can	can	AUX
admet-292	489	4	be	be	AUX
admet-292	489	5	verified	verify	VERB
admet-292	489	6	by	by	ADP
admet-292	489	7	pxrd	pxrd	PROPN
admet-292	489	8	.	.	PUNCT
admet-292	490	1	alex	alex	PROPN
admet-292	490	2	avdeef	avdeef	PROPN
admet-292	490	3	et	et	PROPN
admet-292	490	4	al	al	PROPN
admet-292	490	5	.	.	PROPN
admet-292	490	6	admet	admet	PROPN
admet-292	490	7	&	&	CCONJ
admet-292	490	8	dmpk	dmpk	PROPN
admet-292	490	9	4(2	4(2	NUM
admet-292	490	10	)	)	PUNCT
admet-292	490	11	(	(	PUNCT
admet-292	490	12	2016	2016	NUM
admet-292	490	13	)	)	PUNCT
admet-292	490	14	117	117	NUM
admet-292	490	15	-	-	SYM
admet-292	490	16	178	178	NUM
admet-292	490	17	142	142	NUM
admet-292	490	18	although	although	SCONJ
admet-292	490	19	ms	ms	PROPN
admet-292	490	20	provides	provide	VERB
admet-292	490	21	a	a	DET
admet-292	490	22	clear	clear	ADJ
admet-292	490	23	view	view	NOUN
admet-292	490	24	of	of	ADP
admet-292	490	25	the	the	DET
admet-292	490	26	solutes	solute	NOUN
admet-292	490	27	in	in	ADP
admet-292	490	28	solution	solution	NOUN
admet-292	490	29	,	,	PUNCT
admet-292	490	30	it	it	PRON
admet-292	490	31	is	be	AUX
admet-292	490	32	important	important	ADJ
admet-292	490	33	to	to	PART
admet-292	490	34	notice	notice	VERB
admet-292	490	35	that	that	SCONJ
admet-292	490	36	not	not	PART
admet-292	490	37	all	all	DET
admet-292	490	38	type	type	NOUN
admet-292	490	39	of	of	ADP
admet-292	490	40	compounds	compound	NOUN
admet-292	490	41	are	be	AUX
admet-292	490	42	susceptible	susceptible	ADJ
admet-292	490	43	to	to	PART
admet-292	490	44	be	be	AUX
admet-292	490	45	ionized	ionize	VERB
admet-292	490	46	in	in	ADP
admet-292	490	47	certain	certain	ADJ
admet-292	490	48	conditions	condition	NOUN
admet-292	490	49	(	(	PUNCT
admet-292	490	50	especially	especially	ADV
admet-292	490	51	in	in	ADP
admet-292	490	52	absence	absence	NOUN
admet-292	490	53	of	of	ADP
admet-292	490	54	organic	organic	ADJ
admet-292	490	55	solvents	solvent	NOUN
admet-292	490	56	)	)	PUNCT
admet-292	490	57	.	.	PUNCT
admet-292	491	1	other	other	ADJ
admet-292	491	2	complementary	complementary	ADJ
admet-292	491	3	techniques	technique	NOUN
admet-292	491	4	should	should	AUX
admet-292	491	5	be	be	AUX
admet-292	491	6	considered	consider	VERB
admet-292	491	7	for	for	ADP
admet-292	491	8	solution	solution	NOUN
admet-292	491	9	characterization	characterization	NOUN
admet-292	491	10	of	of	ADP
admet-292	491	11	those	those	DET
admet-292	491	12	compounds	compound	NOUN
admet-292	491	13	that	that	PRON
admet-292	491	14	do	do	AUX
admet-292	491	15	not	not	PART
admet-292	491	16	ionize	ionize	VERB
admet-292	491	17	easily	easily	ADV
admet-292	491	18	,	,	PUNCT
admet-292	491	19	form	form	VERB
admet-292	491	20	neutral	neutral	ADJ
admet-292	491	21	aggregates	aggregate	NOUN
admet-292	491	22	,	,	PUNCT
admet-292	491	23	or	or	CCONJ
admet-292	491	24	have	have	VERB
admet-292	491	25	a	a	DET
admet-292	491	26	high	high	ADJ
admet-292	491	27	aggregation	aggregation	NOUN
admet-292	491	28	number	number	NOUN
admet-292	491	29	such	such	ADJ
admet-292	491	30	as	as	ADP
admet-292	491	31	micelles	micelle	NOUN
admet-292	491	32	,	,	PUNCT
admet-292	491	33	among	among	ADP
admet-292	491	34	others	other	NOUN
admet-292	491	35	.	.	PUNCT
admet-292	492	1	types	type	NOUN
admet-292	492	2	of	of	ADP
admet-292	492	3	solubility	solubility	NOUN
admet-292	492	4	water	water	NOUN
admet-292	492	5	solubility	solubility	PROPN
admet-292	492	6	,	,	PUNCT
admet-292	492	7	sw	sw	PROPN
admet-292	492	8	,	,	PUNCT
admet-292	492	9	and	and	CCONJ
admet-292	492	10	its	its	PRON
admet-292	492	11	relationship	relationship	NOUN
admet-292	492	12	to	to	ADP
admet-292	492	13	intrinsic	intrinsic	ADJ
admet-292	492	14	solubility	solubility	NOUN
admet-292	492	15	,	,	PUNCT
admet-292	492	16	s0	s0	NOUN
admet-292	492	17	the	the	DET
admet-292	492	18	solubility	solubility	NOUN
admet-292	492	19	in	in	ADP
admet-292	492	20	water	water	NOUN
admet-292	492	21	,	,	PUNCT
admet-292	492	22	sw	sw	PROPN
admet-292	492	23	,	,	PUNCT
admet-292	492	24	is	be	AUX
admet-292	492	25	frequently	frequently	ADV
admet-292	492	26	reported	report	VERB
admet-292	492	27	for	for	ADP
admet-292	492	28	ionizable	ionizable	ADJ
admet-292	492	29	druglike	druglike	NOUN
admet-292	492	30	substances	substance	NOUN
admet-292	492	31	.	.	PUNCT
admet-292	493	1	the	the	DET
admet-292	493	2	procedure	procedure	NOUN
admet-292	493	3	calls	call	VERB
admet-292	493	4	for	for	ADP
admet-292	493	5	adding	add	VERB
admet-292	493	6	an	an	DET
admet-292	493	7	unspecified	unspecified	ADJ
admet-292	493	8	“	"	PUNCT
admet-292	493	9	excess	excess	ADJ
admet-292	493	10	”	"	PUNCT
admet-292	493	11	solid	solid	ADJ
admet-292	493	12	(	(	PUNCT
admet-292	493	13	ideally	ideally	ADV
admet-292	493	14	,	,	PUNCT
admet-292	493	15	the	the	DET
admet-292	493	16	free	free	ADJ
admet-292	493	17	-	-	PUNCT
admet-292	493	18	acid	acid	ADJ
admet-292	493	19	or	or	CCONJ
admet-292	493	20	free	free	ADJ
admet-292	493	21	-	-	PUNCT
admet-292	493	22	base	base	NOUN
admet-292	493	23	,	,	PUNCT
admet-292	493	24	not	not	PART
admet-292	493	25	the	the	DET
admet-292	493	26	salt	salt	NOUN
admet-292	493	27	)	)	PUNCT
admet-292	493	28	to	to	ADP
admet-292	493	29	distilled	distil	VERB
admet-292	493	30	water	water	NOUN
admet-292	493	31	,	,	PUNCT
admet-292	493	32	followed	follow	VERB
admet-292	493	33	by	by	ADP
admet-292	493	34	the	the	DET
admet-292	493	35	measurement	measurement	NOUN
admet-292	493	36	of	of	ADP
admet-292	493	37	the	the	DET
admet-292	493	38	substance	substance	NOUN
admet-292	493	39	concentration	concentration	NOUN
admet-292	493	40	after	after	ADP
admet-292	493	41	equilibration	equilibration	NOUN
admet-292	493	42	.	.	PUNCT
admet-292	494	1	frequently	frequently	ADV
admet-292	494	2	,	,	PUNCT
admet-292	494	3	ph	ph	NOUN
admet-292	494	4	of	of	ADP
admet-292	494	5	the	the	DET
admet-292	494	6	saturated	saturate	VERB
admet-292	494	7	solution	solution	NOUN
admet-292	494	8	,	,	PUNCT
admet-292	494	9	phsat	phsat	NOUN
admet-292	494	10	,	,	PUNCT
admet-292	494	11	is	be	AUX
admet-292	494	12	not	not	PART
admet-292	494	13	reported	report	VERB
admet-292	494	14	(	(	PUNCT
admet-292	494	15	and	and	CCONJ
admet-292	494	16	probably	probably	ADV
admet-292	494	17	not	not	PART
admet-292	494	18	measured	measure	VERB
admet-292	494	19	)	)	PUNCT
admet-292	494	20	.	.	PUNCT
admet-292	495	1	usually	usually	ADV
admet-292	495	2	,	,	PUNCT
admet-292	495	3	the	the	DET
admet-292	495	4	reported	report	VERB
admet-292	495	5	experimental	experimental	ADJ
admet-292	495	6	details	detail	NOUN
admet-292	495	7	are	be	AUX
admet-292	495	8	incomplete	incomplete	ADJ
admet-292	495	9	,	,	PUNCT
admet-292	495	10	and	and	CCONJ
admet-292	495	11	so	so	ADV
admet-292	495	12	such	such	ADJ
admet-292	495	13	measurements	measurement	NOUN
admet-292	495	14	can	can	AUX
admet-292	495	15	have	have	VERB
admet-292	495	16	substantial	substantial	ADJ
admet-292	495	17	uncertainty	uncertainty	NOUN
admet-292	495	18	.	.	PUNCT
admet-292	496	1	it	it	PRON
admet-292	496	2	is	be	AUX
admet-292	496	3	useful	useful	ADJ
admet-292	496	4	to	to	PART
admet-292	496	5	consider	consider	VERB
admet-292	496	6	the	the	DET
admet-292	496	7	relationship	relationship	NOUN
admet-292	496	8	between	between	ADP
admet-292	496	9	sw	sw	PROPN
admet-292	496	10	and	and	CCONJ
admet-292	496	11	the	the	DET
admet-292	496	12	intrinsic	intrinsic	ADJ
admet-292	496	13	solubility	solubility	NOUN
admet-292	496	14	,	,	PUNCT
admet-292	496	15	s0	s0	PROPN
admet-292	496	16	,	,	PUNCT
admet-292	496	17	the	the	DET
admet-292	496	18	value	value	NOUN
admet-292	496	19	an	an	DET
admet-292	496	20	ionizable	ionizable	ADJ
admet-292	496	21	molecule	molecule	NOUN
admet-292	496	22	indicates	indicate	VERB
admet-292	496	23	at	at	ADP
admet-292	496	24	the	the	DET
admet-292	496	25	ph	ph	NOUN
admet-292	496	26	where	where	SCONJ
admet-292	496	27	the	the	DET
admet-292	496	28	molecule	molecule	NOUN
admet-292	496	29	is	be	AUX
admet-292	496	30	completely	completely	ADV
admet-292	496	31	uncharged	uncharged	ADJ
admet-292	496	32	(	(	PUNCT
admet-292	496	33	ph<<pka	ph<<pka	NOUN
admet-292	496	34	for	for	ADP
admet-292	496	35	acids	acid	NOUN
admet-292	496	36	or	or	CCONJ
admet-292	496	37	ph>>pka	ph>>pka	NOUN
admet-292	496	38	for	for	ADP
admet-292	496	39	bases	basis	NOUN
admet-292	496	40	;	;	PUNCT
admet-292	496	41	cf	cf	X
admet-292	496	42	.	.	NOUN
admet-292	496	43	,	,	PUNCT
admet-292	496	44	appendix	appendix	VERB
admet-292	496	45	b	b	NOUN
admet-292	496	46	)	)	PUNCT
admet-292	496	47	.	.	PUNCT
admet-292	497	1	when	when	SCONJ
admet-292	497	2	a	a	DET
admet-292	497	3	relatively	relatively	ADV
admet-292	497	4	soluble	soluble	ADJ
admet-292	497	5	weak	weak	ADJ
admet-292	497	6	acid	acid	NOUN
admet-292	497	7	/	/	SYM
admet-292	497	8	base	base	NOUN
admet-292	497	9	is	be	AUX
admet-292	497	10	added	add	VERB
admet-292	497	11	to	to	ADP
admet-292	497	12	water	water	NOUN
admet-292	497	13	,	,	PUNCT
admet-292	497	14	the	the	DET
admet-292	497	15	ph	ph	NOUN
admet-292	497	16	of	of	ADP
admet-292	497	17	the	the	DET
admet-292	497	18	suspension	suspension	NOUN
admet-292	497	19	is	be	AUX
admet-292	497	20	altered	alter	VERB
admet-292	497	21	by	by	ADP
admet-292	497	22	the	the	DET
admet-292	497	23	ionizing	ionize	VERB
admet-292	497	24	molecule	molecule	NOUN
admet-292	497	25	,	,	PUNCT
admet-292	497	26	in	in	ADP
admet-292	497	27	the	the	DET
admet-292	497	28	direction	direction	NOUN
admet-292	497	29	where	where	SCONJ
admet-292	497	30	the	the	DET
admet-292	497	31	molecule	molecule	NOUN
admet-292	497	32	remains	remain	VERB
admet-292	497	33	largely	largely	ADV
admet-292	497	34	in	in	ADP
admet-292	497	35	the	the	DET
admet-292	497	36	uncharged	uncharged	ADJ
admet-292	497	37	form	form	NOUN
admet-292	497	38	:	:	PUNCT
admet-292	497	39	sw	sw	PROPN
admet-292	497	40	≈	≈	PROPN
admet-292	497	41	s0	s0	PROPN
admet-292	497	42	,	,	PUNCT
admet-292	497	43	provided	provide	VERB
admet-292	497	44	the	the	DET
admet-292	497	45	compound	compound	NOUN
admet-292	497	46	is	be	AUX
admet-292	497	47	added	add	VERB
admet-292	497	48	as	as	ADP
admet-292	497	49	a	a	DET
admet-292	497	50	pure	pure	ADJ
admet-292	497	51	free	free	ADJ
admet-292	497	52	acid	acid	NOUN
admet-292	497	53	/	/	SYM
admet-292	497	54	base	base	NOUN
admet-292	497	55	.	.	PUNCT
admet-292	498	1	for	for	ADP
admet-292	498	2	compounds	compound	NOUN
admet-292	498	3	added	add	VERB
admet-292	498	4	as	as	ADP
admet-292	498	5	salts	salt	NOUN
admet-292	498	6	,	,	PUNCT
admet-292	498	7	it	it	PRON
admet-292	498	8	is	be	AUX
admet-292	498	9	frequently	frequently	ADV
admet-292	498	10	not	not	PART
admet-292	498	11	possible	possible	ADJ
admet-292	498	12	to	to	PART
admet-292	498	13	deduce	deduce	VERB
admet-292	498	14	s0	s0	NOUN
admet-292	498	15	and	and	CCONJ
admet-292	498	16	phsat	phsat	VERB
admet-292	498	17	from	from	ADP
admet-292	498	18	just	just	ADV
admet-292	498	19	sw	sw	PROPN
admet-292	498	20	and	and	CCONJ
admet-292	498	21	pka	pka	PROPN
admet-292	498	22	,	,	PUNCT
admet-292	498	23	since	since	SCONJ
admet-292	498	24	the	the	DET
admet-292	498	25	total	total	ADJ
admet-292	498	26	amount	amount	NOUN
admet-292	498	27	of	of	ADP
admet-292	498	28	added	add	VERB
admet-292	498	29	compound	compound	NOUN
admet-292	498	30	can	can	AUX
admet-292	498	31	affect	affect	VERB
admet-292	498	32	the	the	DET
admet-292	498	33	disposition	disposition	NOUN
admet-292	498	34	of	of	ADP
admet-292	498	35	the	the	DET
admet-292	498	36	saturated	saturate	VERB
admet-292	498	37	solution	solution	NOUN
admet-292	498	38	:	:	PUNCT
admet-292	498	39	if	if	SCONJ
admet-292	498	40	not	not	PART
admet-292	498	41	enough	enough	ADJ
admet-292	498	42	of	of	ADP
admet-292	498	43	the	the	DET
admet-292	498	44	drug	drug	NOUN
admet-292	498	45	salt	salt	NOUN
admet-292	498	46	is	be	AUX
admet-292	498	47	added	add	VERB
admet-292	498	48	(	(	PUNCT
admet-292	498	49	i.e.	i.e.	X
admet-292	498	50	,	,	PUNCT
admet-292	498	51	salt	salt	NOUN
admet-292	498	52	solubility	solubility	NOUN
admet-292	498	53	product	product	NOUN
admet-292	498	54	not	not	PART
admet-292	498	55	exceeded	exceed	VERB
admet-292	498	56	)	)	PUNCT
admet-292	498	57	,	,	PUNCT
admet-292	498	58	the	the	DET
admet-292	498	59	solid	solid	ADJ
admet-292	498	60	disproportionates	disproportionate	NOUN
admet-292	498	61	to	to	ADP
admet-292	498	62	the	the	DET
admet-292	498	63	free	free	ADJ
admet-292	498	64	acid	acid	NOUN
admet-292	498	65	/	/	SYM
admet-292	498	66	base	base	NOUN
admet-292	498	67	in	in	ADP
admet-292	498	68	the	the	DET
admet-292	498	69	saturated	saturate	VERB
admet-292	498	70	solution	solution	NOUN
admet-292	498	71	,	,	PUNCT
admet-292	498	72	with	with	ADP
admet-292	498	73	phsat	phsat	NOUN
admet-292	498	74	depending	depend	VERB
admet-292	498	75	on	on	ADP
admet-292	498	76	the	the	DET
admet-292	498	77	weight	weight	NOUN
admet-292	498	78	of	of	ADP
admet-292	498	79	drug	drug	NOUN
admet-292	498	80	salt	salt	NOUN
admet-292	498	81	added	add	VERB
admet-292	498	82	[	[	X
admet-292	498	83	11	11	NUM
admet-292	498	84	]	]	PUNCT
admet-292	498	85	.	.	PUNCT
admet-292	499	1	if	if	SCONJ
admet-292	499	2	the	the	DET
admet-292	499	3	ionizable	ionizable	ADJ
admet-292	499	4	compound	compound	NOUN
admet-292	499	5	is	be	AUX
admet-292	499	6	practically	practically	ADV
admet-292	499	7	insoluble	insoluble	ADJ
admet-292	499	8	,	,	PUNCT
admet-292	499	9	then	then	ADV
admet-292	499	10	the	the	DET
admet-292	499	11	measured	measured	ADJ
admet-292	499	12	value	value	NOUN
admet-292	499	13	of	of	ADP
admet-292	499	14	sw	sw	PROPN
admet-292	499	15	can	can	AUX
admet-292	499	16	be	be	AUX
admet-292	499	17	quite	quite	ADV
admet-292	499	18	different	different	ADJ
admet-292	499	19	from	from	ADP
admet-292	499	20	s0	s0	PROPN
admet-292	499	21	,	,	PUNCT
admet-292	499	22	since	since	SCONJ
admet-292	499	23	not	not	PART
admet-292	499	24	enough	enough	ADJ
admet-292	499	25	of	of	ADP
admet-292	499	26	the	the	DET
admet-292	499	27	compound	compound	NOUN
admet-292	499	28	dissolves	dissolve	VERB
admet-292	499	29	to	to	PART
admet-292	499	30	alter	alter	VERB
admet-292	499	31	the	the	DET
admet-292	499	32	ph	ph	NOUN
admet-292	499	33	in	in	ADP
admet-292	499	34	the	the	DET
admet-292	499	35	direction	direction	NOUN
admet-292	499	36	of	of	ADP
admet-292	499	37	maintaining	maintain	VERB
admet-292	499	38	a	a	DET
admet-292	499	39	nearly	nearly	ADV
admet-292	499	40	uncharged	uncharged	ADJ
admet-292	499	41	molecule	molecule	NOUN
admet-292	499	42	in	in	ADP
admet-292	499	43	the	the	DET
admet-292	499	44	poorly	poorly	ADV
admet-292	499	45	-	-	PUNCT
admet-292	499	46	buffered	buffer	VERB
admet-292	499	47	solution	solution	NOUN
admet-292	499	48	.	.	PUNCT
admet-292	500	1	if	if	SCONJ
admet-292	500	2	the	the	DET
admet-292	500	3	pka	pka	PROPN
admet-292	500	4	is	be	AUX
admet-292	500	5	known	know	VERB
admet-292	500	6	and	and	CCONJ
admet-292	500	7	the	the	DET
admet-292	500	8	henderson	henderson	PROPN
admet-292	500	9	-	-	PUNCT
admet-292	500	10	hasselbalch	hasselbalch	PROPN
admet-292	500	11	(	(	PUNCT
admet-292	500	12	hh	hh	NOUN
admet-292	500	13	)	)	PUNCT
admet-292	500	14	equation	equation	NOUN
admet-292	500	15	is	be	AUX
admet-292	500	16	valid	valid	ADJ
admet-292	500	17	in	in	ADP
admet-292	500	18	the	the	DET
admet-292	500	19	particular	particular	ADJ
admet-292	500	20	case	case	NOUN
admet-292	500	21	,	,	PUNCT
admet-292	500	22	it	it	PRON
admet-292	500	23	is	be	AUX
admet-292	500	24	possible	possible	ADJ
admet-292	500	25	to	to	PART
admet-292	500	26	calculate	calculate	VERB
admet-292	500	27	the	the	DET
admet-292	500	28	phsat	phsat	NOUN
admet-292	500	29	,	,	PUNCT
admet-292	500	30	as	as	ADV
admet-292	500	31	well	well	ADV
admet-292	500	32	as	as	ADP
admet-292	500	33	s0	s0	PROPN
admet-292	500	34	.	.	PUNCT
admet-292	501	1	for	for	ADP
admet-292	501	2	a	a	DET
admet-292	501	3	one	one	NUM
admet-292	501	4	-	-	PUNCT
admet-292	501	5	pka	pka	NOUN
admet-292	501	6	molecule	molecule	NOUN
admet-292	501	7	,	,	PUNCT
admet-292	501	8	logs	log	NOUN
admet-292	501	9	=	=	SYM
admet-292	501	10	logs0	logs0	NOUN
admet-292	502	1	+	+	CCONJ
admet-292	502	2	log[10±(phsat	log[10±(phsat	PROPN
admet-292	502	3	–	–	PUNCT
admet-292	502	4	pka	pka	NOUN
admet-292	502	5	)	)	PUNCT
admet-292	502	6	+	+	CCONJ
admet-292	502	7	1	1	X
admet-292	502	8	]	]	PUNCT
admet-292	502	9	(	(	PUNCT
admet-292	502	10	‘	'	PUNCT
admet-292	502	11	±	±	NUM
admet-292	502	12	’	'	PUNCT
admet-292	502	13	is	be	AUX
admet-292	502	14	‘	'	PUNCT
admet-292	502	15	+	+	NOUN
admet-292	502	16	’	'	PUNCT
admet-292	502	17	for	for	ADP
admet-292	502	18	an	an	DET
admet-292	502	19	acid	acid	ADJ
admet-292	502	20	and	and	CCONJ
admet-292	502	21	‘	'	PUNCT
admet-292	502	22	-	-	PUNCT
admet-292	502	23	‘	'	PUNCT
admet-292	502	24	for	for	ADP
admet-292	502	25	a	a	DET
admet-292	502	26	base	base	NOUN
admet-292	502	27	)	)	PUNCT
admet-292	502	28	.	.	PUNCT
admet-292	503	1	additional	additional	ADJ
admet-292	503	2	henderson	henderson	PROPN
admet-292	503	3	-	-	PUNCT
admet-292	503	4	hasselbalch	hasselbalch	PROPN
admet-292	503	5	equations	equation	NOUN
admet-292	503	6	for	for	ADP
admet-292	503	7	ampholytes	ampholyte	NOUN
admet-292	503	8	and	and	CCONJ
admet-292	503	9	multiprotic	multiprotic	ADJ
admet-292	503	10	acids	acid	NOUN
admet-292	503	11	and	and	CCONJ
admet-292	503	12	bases	basis	NOUN
admet-292	503	13	are	be	AUX
admet-292	503	14	tabulated	tabulate	VERB
admet-292	503	15	in	in	ADP
admet-292	503	16	table	table	NOUN
admet-292	503	17	b.1	b.1	NOUN
admet-292	503	18	in	in	ADP
admet-292	503	19	appendix	appendix	PROPN
admet-292	503	20	b	b	NOUN
admet-292	504	1	[	[	X
admet-292	504	2	21	21	NUM
admet-292	504	3	,	,	PUNCT
admet-292	504	4	27	27	NUM
admet-292	504	5	]	]	PUNCT
admet-292	504	6	.	.	PUNCT
admet-292	505	1	when	when	SCONJ
admet-292	505	2	measured	measure	VERB
admet-292	505	3	compounds	compound	NOUN
admet-292	505	4	contain	contain	VERB
admet-292	505	5	protogenic	protogenic	ADJ
admet-292	505	6	impurities	impurity	NOUN
admet-292	505	7	,	,	PUNCT
admet-292	505	8	the	the	DET
admet-292	505	9	phsat	phsat	NOUN
admet-292	505	10	may	may	AUX
admet-292	505	11	be	be	AUX
admet-292	505	12	affected	affect	VERB
admet-292	505	13	substantially	substantially	ADV
admet-292	505	14	under	under	ADP
admet-292	505	15	poorly	poorly	ADV
admet-292	505	16	-	-	PUNCT
admet-292	505	17	buffered	buffer	VERB
admet-292	505	18	conditions	condition	NOUN
admet-292	505	19	,	,	PUNCT
admet-292	505	20	which	which	PRON
admet-292	505	21	could	could	AUX
admet-292	505	22	lead	lead	VERB
admet-292	505	23	to	to	ADP
admet-292	505	24	a	a	DET
admet-292	505	25	change	change	NOUN
admet-292	505	26	in	in	ADP
admet-292	505	27	the	the	DET
admet-292	505	28	measured	measured	ADJ
admet-292	505	29	sw	sw	PROPN
admet-292	505	30	.	.	PUNCT
admet-292	506	1	under	under	ADP
admet-292	506	2	such	such	ADJ
admet-292	506	3	circumstances	circumstance	NOUN
admet-292	506	4	,	,	PUNCT
admet-292	506	5	the	the	DET
admet-292	506	6	calculation	calculation	NOUN
admet-292	506	7	of	of	ADP
admet-292	506	8	s0	s0	PROPN
admet-292	506	9	from	from	ADP
admet-292	506	10	sw	sw	PROPN
admet-292	506	11	may	may	AUX
admet-292	506	12	be	be	AUX
admet-292	506	13	quite	quite	ADV
admet-292	506	14	inaccurate	inaccurate	ADJ
admet-292	506	15	.	.	PUNCT
admet-292	507	1	abraham	abraham	PROPN
admet-292	507	2	and	and	CCONJ
admet-292	507	3	le	le	X
admet-292	508	1	[	[	X
admet-292	508	2	109	109	NUM
admet-292	508	3	]	]	PUNCT
admet-292	508	4	discussed	discuss	VERB
admet-292	508	5	the	the	DET
admet-292	508	6	relationship	relationship	NOUN
admet-292	508	7	between	between	ADP
admet-292	508	8	the	the	DET
admet-292	508	9	measured	measured	ADJ
admet-292	508	10	sw	sw	PROPN
admet-292	508	11	and	and	CCONJ
admet-292	508	12	s0	s0	PROPN
admet-292	508	13	,	,	PUNCT
admet-292	508	14	and	and	CCONJ
admet-292	508	15	identified	identify	VERB
admet-292	508	16	under	under	ADP
admet-292	508	17	which	which	PRON
admet-292	508	18	circumstances	circumstance	NOUN
admet-292	508	19	large	large	ADJ
admet-292	508	20	differences	difference	NOUN
admet-292	508	21	are	be	AUX
admet-292	508	22	expected	expect	VERB
admet-292	508	23	between	between	ADP
admet-292	508	24	the	the	DET
admet-292	508	25	two	two	NUM
admet-292	508	26	values	value	NOUN
admet-292	508	27	.	.	PUNCT
admet-292	509	1	the	the	DET
admet-292	509	2	authors	author	NOUN
admet-292	509	3	derived	derive	VERB
admet-292	509	4	useful	useful	ADJ
admet-292	509	5	plots	plot	NOUN
admet-292	509	6	of	of	ADP
admet-292	509	7	s0	s0	PROPN
admet-292	509	8	/	/	SYM
admet-292	509	9	sw	sw	PROPN
admet-292	509	10	vs.	vs.	ADP
admet-292	509	11	logsw	logsw	NOUN
admet-292	509	12	for	for	ADP
admet-292	509	13	acids	acid	NOUN
admet-292	509	14	and	and	CCONJ
admet-292	509	15	bases	basis	NOUN
admet-292	509	16	over	over	ADP
admet-292	509	17	a	a	DET
admet-292	509	18	range	range	NOUN
admet-292	509	19	of	of	ADP
admet-292	509	20	pka	pka	PROPN
admet-292	509	21	values	value	NOUN
admet-292	509	22	.	.	PUNCT
admet-292	510	1	for	for	ADP
admet-292	510	2	example	example	NOUN
admet-292	510	3	,	,	PUNCT
admet-292	510	4	for	for	ADP
admet-292	510	5	ionizable	ionizable	ADJ
admet-292	510	6	acids	acid	NOUN
admet-292	510	7	with	with	ADP
admet-292	510	8	pka	pka	PROPN
admet-292	510	9	5	5	NUM
admet-292	510	10	and	and	CCONJ
admet-292	510	11	sw>0.001	sw>0.001	PROPN
admet-292	510	12	m	m	PROPN
admet-292	510	13	,	,	PUNCT
admet-292	510	14	or	or	CCONJ
admet-292	510	15	with	with	ADP
admet-292	510	16	pka	pka	PROPN
admet-292	510	17	3	3	NUM
admet-292	510	18	and	and	CCONJ
admet-292	510	19	sw>0.1	sw>0.1	NOUN
admet-292	510	20	m	m	PROPN
admet-292	510	21	,	,	PUNCT
admet-292	510	22	the	the	DET
admet-292	510	23	water	water	NOUN
admet-292	510	24	solubility	solubility	NOUN
admet-292	510	25	is	be	AUX
admet-292	510	26	practically	practically	ADV
admet-292	510	27	equal	equal	ADJ
admet-292	510	28	to	to	ADP
admet-292	510	29	the	the	DET
admet-292	510	30	intrinsic	intrinsic	ADJ
admet-292	510	31	solubility	solubility	NOUN
admet-292	510	32	.	.	PUNCT
admet-292	511	1	the	the	DET
admet-292	511	2	same	same	ADJ
admet-292	511	3	is	be	AUX
admet-292	511	4	true	true	ADJ
admet-292	511	5	for	for	ADP
admet-292	511	6	ionizable	ionizable	ADJ
admet-292	511	7	bases	basis	NOUN
admet-292	511	8	with	with	ADP
admet-292	511	9	pka	pka	PROPN
admet-292	511	10	10	10	NUM
admet-292	511	11	and	and	CCONJ
admet-292	511	12	sw	sw	X
admet-292	511	13	>	>	X
admet-292	511	14	0.01	0.01	NUM
admet-292	511	15	m	m	PROPN
admet-292	511	16	,	,	PUNCT
admet-292	511	17	or	or	CCONJ
admet-292	511	18	pka	pka	PROPN
admet-292	511	19	8	8	NUM
admet-292	511	20	and	and	CCONJ
admet-292	511	21	sw>0.0001	sw>0.0001	PROPN
admet-292	511	22	m.	m.	NOUN
admet-292	511	23	when	when	SCONJ
admet-292	511	24	the	the	DET
admet-292	511	25	aqueous	aqueous	ADJ
admet-292	511	26	solubility	solubility	NOUN
admet-292	511	27	of	of	ADP
admet-292	511	28	practically	practically	ADV
admet-292	511	29	insoluble	insoluble	ADJ
admet-292	511	30	free	free	ADJ
admet-292	511	31	bases	basis	NOUN
admet-292	511	32	(	(	PUNCT
admet-292	511	33	pka>9	pka>9	PROPN
admet-292	511	34	)	)	PUNCT
admet-292	511	35	is	be	AUX
admet-292	511	36	measured	measure	VERB
admet-292	511	37	in	in	ADP
admet-292	511	38	water	water	NOUN
admet-292	511	39	,	,	PUNCT
admet-292	511	40	the	the	DET
admet-292	511	41	ph	ph	NOUN
admet-292	511	42	is	be	AUX
admet-292	511	43	only	only	ADV
admet-292	511	44	slightly	slightly	ADV
admet-292	511	45	affected	affect	VERB
admet-292	511	46	by	by	ADP
admet-292	511	47	the	the	DET
admet-292	511	48	minute	minute	ADJ
admet-292	511	49	extent	extent	NOUN
admet-292	511	50	to	to	PART
admet-292	511	51	which	which	PRON
admet-292	511	52	the	the	DET
admet-292	511	53	base	base	NOUN
admet-292	511	54	dissolves	dissolve	VERB
admet-292	511	55	.	.	PUNCT
admet-292	512	1	to	to	ADP
admet-292	512	2	a	a	DET
admet-292	512	3	much	much	ADV
admet-292	512	4	greater	great	ADJ
admet-292	512	5	degree	degree	NOUN
admet-292	512	6	,	,	PUNCT
admet-292	512	7	the	the	DET
admet-292	512	8	measured	measured	ADJ
admet-292	512	9	ph	ph	NOUN
admet-292	512	10	is	be	AUX
admet-292	512	11	regulated	regulate	VERB
admet-292	512	12	by	by	ADP
admet-292	512	13	a	a	DET
admet-292	512	14	much	much	ADV
admet-292	512	15	stronger	strong	ADJ
admet-292	512	16	buffer	buffer	NOUN
admet-292	512	17	present	present	ADJ
admet-292	512	18	in	in	ADP
admet-292	512	19	water	water	NOUN
admet-292	512	20	,	,	PUNCT
admet-292	512	21	namely	namely	ADV
admet-292	512	22	,	,	PUNCT
admet-292	512	23	dissolved	dissolve	VERB
admet-292	512	24	carbon	carbon	NOUN
admet-292	512	25	dioxide	dioxide	NOUN
admet-292	512	26	.	.	PUNCT
admet-292	513	1	this	this	PRON
admet-292	513	2	is	be	AUX
admet-292	513	3	often	often	ADV
admet-292	513	4	not	not	PART
admet-292	513	5	admet	admet	PROPN
admet-292	513	6	&	&	CCONJ
admet-292	513	7	dmpk	dmpk	PROPN
admet-292	513	8	4(2	4(2	NUM
admet-292	513	9	)	)	PUNCT
admet-292	513	10	(	(	PUNCT
admet-292	513	11	2016	2016	NUM
admet-292	513	12	)	)	PUNCT
admet-292	513	13	117	117	NUM
admet-292	513	14	-	-	SYM
admet-292	513	15	178	178	NUM
admet-292	513	16	consensus	consensus	NOUN
admet-292	513	17	recommendations	recommendation	NOUN
admet-292	513	18	for	for	ADP
admet-292	513	19	improving	improve	VERB
admet-292	513	20	solubility	solubility	NOUN
admet-292	513	21	-	-	PUNCT
admet-292	513	22	ph	ph	ADJ
admet-292	513	23	data	datum	NOUN
admet-292	513	24	quality	quality	NOUN
admet-292	513	25	doi	doi	NOUN
admet-292	513	26	:	:	PUNCT
admet-292	513	27	10.5599	10.5599	NUM
admet-292	513	28	/	/	SYM
admet-292	513	29	admet.4.2.292	admet.4.2.292	NUM
admet-292	513	30	143	143	NUM
admet-292	513	31	factored	factor	VERB
admet-292	513	32	in	in	ADP
admet-292	513	33	.	.	PUNCT
admet-292	514	1	in	in	ADP
admet-292	514	2	the	the	DET
admet-292	514	3	(	(	PUNCT
admet-292	514	4	unlikely	unlikely	ADJ
admet-292	514	5	)	)	PUNCT
admet-292	514	6	absence	absence	NOUN
admet-292	514	7	of	of	ADP
admet-292	514	8	co2	co2	NOUN
admet-292	514	9	,	,	PUNCT
admet-292	514	10	the	the	DET
admet-292	514	11	drug	drug	NOUN
admet-292	514	12	-	-	PUNCT
admet-292	514	13	saturated	saturate	VERB
admet-292	514	14	solution	solution	NOUN
admet-292	514	15	may	may	AUX
admet-292	514	16	be	be	AUX
admet-292	514	17	at	at	ADP
admet-292	514	18	ph>9	ph>9	NOUN
admet-292	514	19	.	.	PUNCT
admet-292	515	1	but	but	CCONJ
admet-292	515	2	the	the	DET
admet-292	515	3	presence	presence	NOUN
admet-292	515	4	of	of	ADP
admet-292	515	5	dissolved	dissolve	VERB
admet-292	515	6	co2	co2	NOUN
admet-292	515	7	can	can	AUX
admet-292	515	8	lower	lower	VERB
admet-292	515	9	the	the	DET
admet-292	515	10	ph<6	ph<6	PROPN
admet-292	515	11	,	,	PUNCT
admet-292	515	12	depending	depend	VERB
admet-292	515	13	on	on	ADP
admet-292	515	14	the	the	DET
admet-292	515	15	level	level	NOUN
admet-292	515	16	of	of	ADP
admet-292	515	17	co2	co2	NOUN
admet-292	515	18	and	and	CCONJ
admet-292	515	19	how	how	SCONJ
admet-292	515	20	insoluble	insoluble	ADJ
admet-292	515	21	the	the	DET
admet-292	515	22	basic	basic	ADJ
admet-292	515	23	compound	compound	NOUN
admet-292	515	24	is	be	AUX
admet-292	515	25	.	.	PUNCT
admet-292	516	1	rytting	rytte	VERB
admet-292	516	2	et	et	NOUN
admet-292	516	3	al	al	PROPN
admet-292	516	4	.	.	PUNCT
admet-292	517	1	[	[	X
admet-292	517	2	110	110	NUM
admet-292	517	3	]	]	PUNCT
admet-292	517	4	reported	report	VERB
admet-292	517	5	logsw=-4.87	logsw=-4.87	NOUN
admet-292	517	6	for	for	ADP
admet-292	517	7	terfenadine	terfenadine	NOUN
admet-292	517	8	dissolved	dissolve	VERB
admet-292	517	9	in	in	ADP
admet-292	517	10	water	water	NOUN
admet-292	517	11	,	,	PUNCT
admet-292	517	12	with	with	ADP
admet-292	517	13	no	no	DET
admet-292	517	14	further	further	ADJ
admet-292	517	15	information	information	NOUN
admet-292	517	16	.	.	PUNCT
admet-292	518	1	if	if	SCONJ
admet-292	518	2	ambient	ambient	ADJ
admet-292	518	3	[	[	X
admet-292	518	4	co2	co2	X
admet-292	518	5	]	]	X
admet-292	518	6	=	=	SYM
admet-292	518	7	{	{	PUNCT
admet-292	518	8	0	0	NUM
admet-292	518	9	,	,	PUNCT
admet-292	518	10	10	10	NUM
admet-292	518	11	,	,	PUNCT
admet-292	518	12	20	20	NUM
admet-292	518	13	}	}	SYM
admet-292	518	14	μm	μm	NOUN
admet-292	518	15	,	,	PUNCT
admet-292	518	16	the	the	DET
admet-292	518	17	calculated	calculated	ADJ
admet-292	518	18	logs0	logs0	NOUN
admet-292	519	1	=	=	PRON
admet-292	519	2	{	{	PUNCT
admet-292	519	3	-5.7	-5.7	PROPN
admet-292	519	4	,	,	PUNCT
admet-292	519	5	-6.3	-6.3	NOUN
admet-292	519	6	,	,	PUNCT
admet-292	519	7	-8.3	-8.3	ADJ
admet-292	519	8	}	}	PUNCT
admet-292	519	9	and	and	CCONJ
admet-292	519	10	phsat	phsat	NOUN
admet-292	519	11	=	=	PUNCT
admet-292	519	12	{	{	PUNCT
admet-292	519	13	9.2	9.2	NUM
admet-292	519	14	,	,	PUNCT
admet-292	519	15	8.5	8.5	NUM
admet-292	519	16	,	,	PUNCT
admet-292	519	17	6.6	6.6	NUM
admet-292	519	18	}	}	PUNCT
admet-292	519	19	,	,	PUNCT
admet-292	519	20	respectively	respectively	ADV
admet-292	519	21	.	.	PUNCT
admet-292	520	1	consequently	consequently	ADV
admet-292	520	2	,	,	PUNCT
admet-292	520	3	the	the	DET
admet-292	520	4	error	error	NOUN
admet-292	520	5	in	in	ADP
admet-292	520	6	the	the	DET
admet-292	520	7	calculated	calculated	ADJ
admet-292	520	8	s0	s0	NOUN
admet-292	520	9	of	of	ADP
admet-292	520	10	practically	practically	ADV
admet-292	520	11	insoluble	insoluble	ADJ
admet-292	520	12	basic	basic	ADJ
admet-292	520	13	drugs	drug	NOUN
admet-292	520	14	in	in	ADP
admet-292	520	15	water	water	NOUN
admet-292	520	16	is	be	AUX
admet-292	520	17	expected	expect	VERB
admet-292	520	18	to	to	PART
admet-292	520	19	be	be	AUX
admet-292	520	20	enormous	enormous	ADJ
admet-292	520	21	(	(	PUNCT
admet-292	520	22	up	up	ADP
admet-292	520	23	to	to	PART
admet-292	520	24	3	3	NUM
admet-292	520	25	log	log	NOUN
admet-292	520	26	units	unit	NOUN
admet-292	520	27	)	)	PUNCT
admet-292	520	28	,	,	PUNCT
admet-292	520	29	since	since	SCONJ
admet-292	520	30	it	it	PRON
admet-292	520	31	is	be	AUX
admet-292	520	32	very	very	ADV
admet-292	520	33	difficult	difficult	ADJ
admet-292	520	34	to	to	PART
admet-292	520	35	eliminate	eliminate	VERB
admet-292	520	36	co2	co2	NOUN
admet-292	520	37	entirely	entirely	ADV
admet-292	520	38	simply	simply	ADV
admet-292	520	39	by	by	ADP
admet-292	520	40	bubbling	bubble	VERB
admet-292	520	41	an	an	DET
admet-292	520	42	inert	inert	ADJ
admet-292	520	43	gas	gas	NOUN
admet-292	520	44	(	(	PUNCT
admet-292	520	45	ar	ar	PROPN
admet-292	520	46	,	,	PUNCT
admet-292	520	47	n2	n2	NOUN
admet-292	520	48	,	,	PUNCT
admet-292	520	49	he	he	PRON
admet-292	520	50	)	)	PUNCT
admet-292	520	51	through	through	ADP
admet-292	520	52	the	the	DET
admet-292	520	53	solution	solution	NOUN
admet-292	520	54	.	.	PUNCT
admet-292	521	1	furthermore	furthermore	ADV
admet-292	521	2	,	,	PUNCT
admet-292	521	3	any	any	DET
admet-292	521	4	protogenic	protogenic	ADJ
admet-292	521	5	drug	drug	NOUN
admet-292	521	6	impurity	impurity	NOUN
admet-292	521	7	in	in	ADP
admet-292	521	8	water	water	NOUN
admet-292	521	9	under	under	ADP
admet-292	521	10	the	the	DET
admet-292	521	11	circumstances	circumstance	NOUN
admet-292	521	12	would	would	AUX
admet-292	521	13	also	also	ADV
admet-292	521	14	lead	lead	VERB
admet-292	521	15	to	to	ADP
admet-292	521	16	large	large	ADJ
admet-292	521	17	uncertainties	uncertainty	NOUN
admet-292	521	18	in	in	ADP
admet-292	521	19	the	the	DET
admet-292	521	20	hh	hh	ADJ
admet-292	521	21	-	-	PUNCT
admet-292	521	22	calculated	calculate	VERB
admet-292	521	23	s0	s0	NOUN
admet-292	521	24	.	.	PUNCT
admet-292	522	1	that	that	PRON
admet-292	522	2	is	be	AUX
admet-292	522	3	why	why	SCONJ
admet-292	522	4	one	one	PRON
admet-292	522	5	ought	ought	AUX
admet-292	522	6	to	to	PART
admet-292	522	7	actually	actually	ADV
admet-292	522	8	measure	measure	VERB
admet-292	522	9	the	the	DET
admet-292	522	10	ph	ph	NOUN
admet-292	522	11	of	of	ADP
admet-292	522	12	the	the	DET
admet-292	522	13	saturated	saturate	VERB
admet-292	522	14	solution	solution	NOUN
admet-292	522	15	.	.	PUNCT
admet-292	523	1	but	but	CCONJ
admet-292	523	2	,	,	PUNCT
admet-292	523	3	measuring	measure	VERB
admet-292	523	4	the	the	DET
admet-292	523	5	ph	ph	NOUN
admet-292	523	6	accurately	accurately	ADV
admet-292	523	7	of	of	ADP
admet-292	523	8	an	an	DET
admet-292	523	9	unbuffered	unbuffered	ADJ
admet-292	523	10	solution	solution	NOUN
admet-292	523	11	is	be	AUX
admet-292	523	12	another	another	DET
admet-292	523	13	problem	problem	NOUN
admet-292	523	14	,	,	PUNCT
admet-292	523	15	due	due	ADP
admet-292	523	16	to	to	ADP
admet-292	523	17	the	the	DET
admet-292	523	18	effects	effect	NOUN
admet-292	523	19	of	of	ADP
admet-292	523	20	uncontrolled	uncontrolled	ADJ
admet-292	523	21	electrode	electrode	NOUN
admet-292	523	22	junction	junction	NOUN
admet-292	523	23	potentials	potential	NOUN
admet-292	523	24	and	and	CCONJ
admet-292	523	25	possibly	possibly	ADV
admet-292	523	26	inappropriately	inappropriately	ADV
admet-292	523	27	calibrated	calibrate	VERB
admet-292	523	28	ph	ph	ADJ
admet-292	523	29	electrodes	electrode	NOUN
admet-292	523	30	[	[	X
admet-292	523	31	27	27	NUM
admet-292	523	32	]	]	PUNCT
admet-292	523	33	.	.	PUNCT
admet-292	524	1	the	the	DET
admet-292	524	2	addition	addition	NOUN
admet-292	524	3	of	of	ADP
admet-292	524	4	a	a	DET
admet-292	524	5	background	background	NOUN
admet-292	524	6	electrolyte	electrolyte	NOUN
admet-292	524	7	(	(	PUNCT
admet-292	524	8	e.g.	e.g.	ADV
admet-292	524	9	,	,	PUNCT
admet-292	524	10	0.15	0.15	NUM
admet-292	524	11	m	m	NOUN
admet-292	524	12	nacl	nacl	NOUN
admet-292	524	13	)	)	PUNCT
admet-292	524	14	would	would	AUX
admet-292	524	15	lessen	lessen	VERB
admet-292	524	16	the	the	DET
admet-292	524	17	junction	junction	NOUN
admet-292	524	18	potential	potential	ADJ
admet-292	524	19	error	error	NOUN
admet-292	524	20	.	.	PUNCT
admet-292	525	1	solubility	solubility	NOUN
admet-292	525	2	in	in	ADP
admet-292	525	3	a	a	DET
admet-292	525	4	single	single	ADJ
admet-292	525	5	buffered	buffer	VERB
admet-292	525	6	solution	solution	NOUN
admet-292	525	7	,	,	PUNCT
admet-292	525	8	sph	sph	NOUN
admet-292	525	9	the	the	DET
admet-292	525	10	use	use	NOUN
admet-292	525	11	of	of	ADP
admet-292	525	12	a	a	DET
admet-292	525	13	buffered	buffer	VERB
admet-292	525	14	solution	solution	NOUN
admet-292	525	15	lessens	lessen	VERB
admet-292	525	16	some	some	PRON
admet-292	525	17	of	of	ADP
admet-292	525	18	the	the	DET
admet-292	525	19	uncertainties	uncertainty	NOUN
admet-292	525	20	associated	associate	VERB
admet-292	525	21	with	with	ADP
admet-292	525	22	ph	ph	ADJ
admet-292	525	23	measurement	measurement	NOUN
admet-292	525	24	and	and	CCONJ
admet-292	525	25	the	the	DET
admet-292	525	26	impact	impact	NOUN
admet-292	525	27	of	of	ADP
admet-292	525	28	trace	trace	NOUN
admet-292	525	29	impurities	impurity	NOUN
admet-292	525	30	.	.	PUNCT
admet-292	526	1	the	the	DET
admet-292	526	2	ph	ph	NOUN
admet-292	526	3	of	of	ADP
admet-292	526	4	the	the	DET
admet-292	526	5	saturated	saturate	VERB
admet-292	526	6	drug	drug	NOUN
admet-292	526	7	solution	solution	NOUN
admet-292	526	8	still	still	ADV
admet-292	526	9	needs	need	VERB
admet-292	526	10	to	to	PART
admet-292	526	11	be	be	AUX
admet-292	526	12	carefully	carefully	ADV
admet-292	526	13	measured	measure	VERB
admet-292	526	14	after	after	ADP
admet-292	526	15	equilibration	equilibration	NOUN
admet-292	526	16	.	.	PUNCT
admet-292	527	1	still	still	ADV
admet-292	527	2	,	,	PUNCT
admet-292	527	3	to	to	PART
admet-292	527	4	convert	convert	VERB
admet-292	527	5	the	the	DET
admet-292	527	6	sph	sph	NOUN
admet-292	527	7	to	to	ADP
admet-292	527	8	the	the	DET
admet-292	527	9	intrinsic	intrinsic	ADJ
admet-292	527	10	value	value	NOUN
admet-292	527	11	,	,	PUNCT
admet-292	527	12	s0	s0	PROPN
admet-292	527	13	,	,	PUNCT
admet-292	527	14	it	it	PRON
admet-292	527	15	is	be	AUX
admet-292	527	16	necessary	necessary	ADJ
admet-292	527	17	to	to	PART
admet-292	527	18	know	know	VERB
admet-292	527	19	the	the	DET
admet-292	527	20	independentlymeasured	independentlymeasure	VERB
admet-292	527	21	pka	pka	NOUN
admet-292	527	22	and	and	CCONJ
admet-292	527	23	the	the	DET
admet-292	527	24	application	application	NOUN
admet-292	527	25	of	of	ADP
admet-292	527	26	the	the	DET
admet-292	527	27	hh	hh	PROPN
admet-292	527	28	equation	equation	NOUN
admet-292	527	29	(	(	PUNCT
admet-292	527	30	provided	provide	VERB
admet-292	527	31	it	it	PRON
admet-292	527	32	is	be	AUX
admet-292	527	33	valid	valid	ADJ
admet-292	527	34	for	for	ADP
admet-292	527	35	the	the	DET
admet-292	527	36	studied	study	VERB
admet-292	527	37	molecule	molecule	NOUN
admet-292	527	38	)	)	PUNCT
admet-292	527	39	.	.	PUNCT
admet-292	528	1	intrinsic	intrinsic	ADJ
admet-292	528	2	solubility	solubility	PROPN
admet-292	528	3	,	,	PUNCT
admet-292	528	4	s0	s0	PROPN
admet-292	528	5	,	,	PUNCT
admet-292	528	6	from	from	ADP
admet-292	528	7	multiple	multiple	ADJ
admet-292	528	8	logs	log	NOUN
admet-292	528	9	-	-	PUNCT
admet-292	528	10	ph	ph	ADJ
admet-292	528	11	measurements	measurement	NOUN
admet-292	528	12	when	when	SCONJ
admet-292	528	13	critically	critically	ADV
admet-292	528	14	comparing	compare	VERB
admet-292	528	15	the	the	DET
admet-292	528	16	solubility	solubility	NOUN
admet-292	528	17	of	of	ADP
admet-292	528	18	different	different	ADJ
admet-292	528	19	molecules	molecule	NOUN
admet-292	528	20	,	,	PUNCT
admet-292	528	21	the	the	DET
admet-292	528	22	intrinsic	intrinsic	ADJ
admet-292	528	23	value	value	NOUN
admet-292	528	24	is	be	AUX
admet-292	528	25	the	the	DET
admet-292	528	26	appropriate	appropriate	ADJ
admet-292	528	27	one	one	NOUN
admet-292	528	28	to	to	PART
admet-292	528	29	consider	consider	VERB
admet-292	528	30	.	.	PUNCT
admet-292	529	1	the	the	DET
admet-292	529	2	most	most	ADV
admet-292	529	3	general	general	ADJ
admet-292	529	4	way	way	NOUN
admet-292	529	5	to	to	PART
admet-292	529	6	determine	determine	VERB
admet-292	529	7	the	the	DET
admet-292	529	8	intrinsic	intrinsic	ADJ
admet-292	529	9	solubility	solubility	NOUN
admet-292	529	10	,	,	PUNCT
admet-292	529	11	s0	s0	PROPN
admet-292	529	12	,	,	PUNCT
admet-292	529	13	requires	require	VERB
admet-292	529	14	multiple	multiple	ADJ
admet-292	529	15	ph	ph	ADJ
admet-292	529	16	measurements	measurement	NOUN
admet-292	529	17	using	use	VERB
admet-292	529	18	the	the	DET
admet-292	529	19	sf	sf	PROPN
admet-292	529	20	method	method	NOUN
admet-292	529	21	.	.	PUNCT
admet-292	530	1	ionizable	ionizable	ADJ
admet-292	530	2	/	/	SYM
admet-292	530	3	nonionizable	nonionizable	ADJ
admet-292	530	4	drugs	drug	NOUN
admet-292	530	5	may	may	AUX
admet-292	530	6	be	be	AUX
admet-292	530	7	considered	consider	VERB
admet-292	530	8	,	,	PUNCT
admet-292	530	9	as	as	ADV
admet-292	530	10	well	well	ADV
admet-292	530	11	as	as	ADP
admet-292	530	12	reactions	reaction	NOUN
admet-292	530	13	that	that	PRON
admet-292	530	14	form	form	VERB
admet-292	530	15	drug	drug	NOUN
admet-292	530	16	salts	salt	NOUN
admet-292	530	17	,	,	PUNCT
admet-292	530	18	complexes	complex	NOUN
admet-292	530	19	,	,	PUNCT
admet-292	530	20	aggregates	aggregate	NOUN
admet-292	530	21	/	/	SYM
admet-292	530	22	micelles	micelle	NOUN
admet-292	530	23	,	,	PUNCT
admet-292	530	24	or	or	CCONJ
admet-292	530	25	cocrystals	cocrystal	NOUN
admet-292	530	26	.	.	PUNCT
admet-292	531	1	cheqsol	cheqsol	PROPN
admet-292	531	2	is	be	AUX
admet-292	531	3	also	also	ADV
admet-292	531	4	a	a	DET
admet-292	531	5	good	good	ADJ
admet-292	531	6	way	way	NOUN
admet-292	531	7	to	to	PART
admet-292	531	8	determine	determine	VERB
admet-292	531	9	intrinsic	intrinsic	ADJ
admet-292	531	10	solubility	solubility	NOUN
admet-292	531	11	of	of	ADP
admet-292	531	12	ionizable	ionizable	ADJ
admet-292	531	13	drugs	drug	NOUN
admet-292	531	14	.	.	PUNCT
admet-292	532	1	interferences	interference	NOUN
admet-292	532	2	due	due	ADJ
admet-292	532	3	to	to	ADP
admet-292	532	4	buffers	buffer	NOUN
admet-292	532	5	,	,	PUNCT
admet-292	532	6	salts	salt	NOUN
admet-292	532	7	,	,	PUNCT
admet-292	532	8	or	or	CCONJ
admet-292	532	9	complexing	complexe	VERB
admet-292	532	10	agents	agent	NOUN
admet-292	532	11	are	be	AUX
admet-292	532	12	generally	generally	ADV
admet-292	532	13	avoided	avoid	VERB
admet-292	532	14	.	.	PUNCT
admet-292	533	1	several	several	ADJ
admet-292	533	2	of	of	ADP
admet-292	533	3	the	the	DET
admet-292	533	4	preceding	precede	VERB
admet-292	533	5	case	case	NOUN
admet-292	533	6	studies	study	NOUN
admet-292	533	7	illustrate	illustrate	VERB
admet-292	533	8	how	how	SCONJ
admet-292	533	9	complicated	complicate	VERB
admet-292	533	10	the	the	DET
admet-292	533	11	analysis	analysis	NOUN
admet-292	533	12	of	of	ADP
admet-292	533	13	logs	log	NOUN
admet-292	533	14	-	-	PUNCT
admet-292	533	15	ph	ph	NOUN
admet-292	533	16	can	can	AUX
admet-292	533	17	be	be	AUX
admet-292	533	18	.	.	PUNCT
admet-292	534	1	when	when	SCONJ
admet-292	534	2	measuring	measure	VERB
admet-292	534	3	several	several	ADJ
admet-292	534	4	different	different	ADJ
admet-292	534	5	logs	log	NOUN
admet-292	534	6	-	-	PUNCT
admet-292	534	7	ph	ph	ADJ
admet-292	534	8	points	point	NOUN
admet-292	534	9	,	,	PUNCT
admet-292	534	10	both	both	CCONJ
admet-292	534	11	below	below	ADP
admet-292	534	12	and	and	CCONJ
admet-292	534	13	above	above	ADP
admet-292	534	14	the	the	DET
admet-292	534	15	pka	pka	NOUN
admet-292	534	16	(	(	PUNCT
admet-292	534	17	and	and	CCONJ
admet-292	534	18	pka	pka	PROPN
admet-292	534	19	gibbs	gibbs	PROPN
admet-292	534	20	with	with	ADP
admet-292	534	21	drug	drug	NOUN
admet-292	534	22	salt	salt	NOUN
admet-292	534	23	precipitates	precipitate	NOUN
admet-292	534	24	)	)	PUNCT
admet-292	534	25	,	,	PUNCT
admet-292	534	26	it	it	PRON
admet-292	534	27	is	be	AUX
admet-292	534	28	not	not	PART
admet-292	534	29	necessary	necessary	ADJ
admet-292	534	30	to	to	PART
admet-292	534	31	rely	rely	VERB
admet-292	534	32	on	on	ADP
admet-292	534	33	simple	simple	ADJ
admet-292	534	34	hh	hh	ADJ
admet-292	534	35	equations	equation	NOUN
admet-292	534	36	(	(	PUNCT
admet-292	534	37	which	which	PRON
admet-292	534	38	might	might	AUX
admet-292	534	39	not	not	PART
admet-292	534	40	accurately	accurately	ADV
admet-292	534	41	predict	predict	VERB
admet-292	534	42	the	the	DET
admet-292	534	43	logs	log	NOUN
admet-292	534	44	dependence	dependence	NOUN
admet-292	534	45	on	on	ADP
admet-292	534	46	ph	ph	PROPN
admet-292	534	47	)	)	PUNCT
admet-292	534	48	.	.	PUNCT
admet-292	535	1	buffers	buffer	NOUN
admet-292	535	2	may	may	AUX
admet-292	535	3	be	be	AUX
admet-292	535	4	required	require	VERB
admet-292	535	5	to	to	PART
admet-292	535	6	cover	cover	VERB
admet-292	535	7	the	the	DET
admet-292	535	8	regions	region	NOUN
admet-292	535	9	of	of	ADP
admet-292	535	10	ph	ph	NOUN
admet-292	535	11	poorly	poorly	ADV
admet-292	535	12	buffered	buffer	VERB
admet-292	535	13	by	by	ADP
admet-292	535	14	the	the	DET
admet-292	535	15	drug	drug	NOUN
admet-292	535	16	molecule	molecule	NOUN
admet-292	535	17	.	.	PUNCT
admet-292	536	1	also	also	ADV
admet-292	536	2	,	,	PUNCT
admet-292	536	3	buffers	buffer	NOUN
admet-292	536	4	may	may	AUX
admet-292	536	5	facilitate	facilitate	VERB
admet-292	536	6	the	the	DET
admet-292	536	7	uniform	uniform	ADJ
admet-292	536	8	ph	ph	ADJ
admet-292	536	9	adjustments	adjustment	NOUN
admet-292	536	10	of	of	ADP
admet-292	536	11	the	the	DET
admet-292	536	12	solutions	solution	NOUN
admet-292	536	13	using	use	VERB
admet-292	536	14	standardized	standardized	ADJ
admet-292	536	15	titrants	titrant	NOUN
admet-292	536	16	.	.	PUNCT
admet-292	537	1	other	other	ADJ
admet-292	537	2	solubility	solubility	NOUN
admet-292	537	3	terms	term	NOUN
admet-292	537	4	used	use	VERB
admet-292	537	5	in	in	ADP
admet-292	537	6	the	the	DET
admet-292	537	7	literature	literature	NOUN
admet-292	537	8	other	other	ADJ
admet-292	537	9	solubility	solubility	NOUN
admet-292	537	10	terms	term	NOUN
admet-292	537	11	(	(	PUNCT
admet-292	537	12	e.g.	e.g.	ADV
admet-292	537	13	,	,	PUNCT
admet-292	537	14	biological	biological	ADJ
admet-292	537	15	,	,	PUNCT
admet-292	537	16	native	native	ADJ
admet-292	537	17	,	,	PUNCT
admet-292	537	18	natural	natural	ADJ
admet-292	537	19	,	,	PUNCT
admet-292	537	20	unbuffered	unbuffered	ADJ
admet-292	537	21	,	,	PUNCT
admet-292	537	22	turbidimetric	turbidimetric	ADJ
admet-292	537	23	,	,	PUNCT
admet-292	537	24	kinetic	kinetic	NOUN
admet-292	537	25	)	)	PUNCT
admet-292	537	26	are	be	AUX
admet-292	537	27	used	use	VERB
admet-292	537	28	in	in	ADP
admet-292	537	29	the	the	DET
admet-292	537	30	literature	literature	NOUN
admet-292	537	31	.	.	PUNCT
admet-292	538	1	we	we	PRON
admet-292	538	2	encourage	encourage	VERB
admet-292	538	3	practitioners	practitioner	NOUN
admet-292	538	4	to	to	PART
admet-292	538	5	give	give	VERB
admet-292	538	6	careful	careful	ADJ
admet-292	538	7	consideration	consideration	NOUN
admet-292	538	8	to	to	ADP
admet-292	538	9	the	the	DET
admet-292	538	10	meaning	meaning	NOUN
admet-292	538	11	of	of	ADP
admet-292	538	12	the	the	DET
admet-292	538	13	terms	term	NOUN
admet-292	538	14	used	use	VERB
admet-292	538	15	to	to	PART
admet-292	538	16	associate	associate	VERB
admet-292	538	17	with	with	ADP
admet-292	538	18	solubility	solubility	NOUN
admet-292	538	19	.	.	PUNCT
admet-292	539	1	at	at	ADP
admet-292	539	2	times	time	NOUN
admet-292	539	3	these	these	DET
admet-292	539	4	lesser	less	ADJ
admet-292	539	5	-	-	PUNCT
admet-292	539	6	common	common	ADJ
admet-292	539	7	terms	term	NOUN
admet-292	539	8	have	have	AUX
admet-292	539	9	been	be	AUX
admet-292	539	10	used	use	VERB
admet-292	539	11	without	without	ADP
admet-292	539	12	critical	critical	ADJ
admet-292	539	13	definition	definition	NOUN
admet-292	539	14	or	or	CCONJ
admet-292	539	15	sufficiently	sufficiently	ADV
admet-292	539	16	rigorous	rigorous	ADJ
admet-292	539	17	measurement	measurement	NOUN
admet-292	539	18	practices	practice	NOUN
admet-292	539	19	.	.	PUNCT
admet-292	540	1	alex	alex	PROPN
admet-292	540	2	avdeef	avdeef	PROPN
admet-292	540	3	et	et	PROPN
admet-292	540	4	al	al	PROPN
admet-292	540	5	.	.	PROPN
admet-292	540	6	admet	admet	PROPN
admet-292	540	7	&	&	CCONJ
admet-292	540	8	dmpk	dmpk	PROPN
admet-292	540	9	4(2	4(2	NUM
admet-292	540	10	)	)	PUNCT
admet-292	540	11	(	(	PUNCT
admet-292	540	12	2016	2016	NUM
admet-292	540	13	)	)	PUNCT
admet-292	540	14	117	117	NUM
admet-292	540	15	-	-	SYM
admet-292	540	16	178	178	NUM
admet-292	540	17	144	144	NUM
admet-292	540	18	temperature	temperature	NOUN
admet-292	540	19	solubility	solubility	NOUN
admet-292	540	20	is	be	AUX
admet-292	540	21	a	a	DET
admet-292	540	22	function	function	NOUN
admet-292	540	23	of	of	ADP
admet-292	540	24	temperature	temperature	NOUN
admet-292	540	25	,	,	PUNCT
admet-292	540	26	so	so	CCONJ
admet-292	540	27	the	the	DET
admet-292	540	28	assay	assay	NOUN
admet-292	540	29	temperature	temperature	NOUN
admet-292	540	30	always	always	ADV
admet-292	540	31	needs	need	VERB
admet-292	540	32	to	to	PART
admet-292	540	33	be	be	AUX
admet-292	540	34	reported	report	VERB
admet-292	540	35	.	.	PUNCT
admet-292	541	1	it	it	PRON
admet-292	541	2	is	be	AUX
admet-292	541	3	advisable	advisable	ADJ
admet-292	541	4	to	to	PART
admet-292	541	5	measure	measure	VERB
admet-292	541	6	and	and	CCONJ
admet-292	541	7	record	record	VERB
admet-292	541	8	the	the	DET
admet-292	541	9	actual	actual	ADJ
admet-292	541	10	temperature	temperature	NOUN
admet-292	541	11	in	in	ADP
admet-292	541	12	the	the	DET
admet-292	541	13	sample	sample	NOUN
admet-292	541	14	vessel	vessel	NOUN
admet-292	541	15	during	during	ADP
admet-292	541	16	the	the	DET
admet-292	541	17	equilibration	equilibration	NOUN
admet-292	541	18	period	period	NOUN
admet-292	541	19	.	.	PUNCT
admet-292	542	1	or	or	CCONJ
admet-292	542	2	better	well	ADV
admet-292	542	3	yet	yet	ADV
admet-292	542	4	,	,	PUNCT
admet-292	542	5	the	the	DET
admet-292	542	6	measurement	measurement	NOUN
admet-292	542	7	is	be	AUX
admet-292	542	8	performed	perform	VERB
admet-292	542	9	in	in	ADP
admet-292	542	10	a	a	DET
admet-292	542	11	thermostated	thermostated	ADJ
admet-292	542	12	vessel	vessel	NOUN
admet-292	542	13	kept	keep	VERB
admet-292	542	14	at	at	ADP
admet-292	542	15	25/37	25/37	NUM
admet-292	542	16	°	°	ADP
admet-292	542	17	c	c	NOUN
admet-292	542	18	.	.	PUNCT
admet-292	543	1	it	it	PRON
admet-292	543	2	is	be	AUX
admet-292	543	3	clear	clear	ADJ
admet-292	543	4	that	that	SCONJ
admet-292	543	5	unspecified	unspecified	ADJ
admet-292	543	6	“	"	PUNCT
admet-292	543	7	room	room	NOUN
admet-292	543	8	temperature	temperature	NOUN
admet-292	543	9	”	"	PUNCT
admet-292	543	10	can	can	AUX
admet-292	543	11	be	be	AUX
admet-292	543	12	different	different	ADJ
admet-292	543	13	from	from	ADP
admet-292	543	14	laboratory	laboratory	NOUN
admet-292	543	15	to	to	ADP
admet-292	543	16	laboratory	laboratory	NOUN
admet-292	543	17	,	,	PUNCT
admet-292	543	18	and	and	CCONJ
admet-292	543	19	in	in	ADP
admet-292	543	20	some	some	DET
admet-292	543	21	cases	case	NOUN
admet-292	543	22	,	,	PUNCT
admet-292	543	23	seasonally	seasonally	ADV
admet-292	543	24	variable	variable	ADJ
admet-292	543	25	.	.	PUNCT
admet-292	544	1	when	when	SCONJ
admet-292	544	2	solubility	solubility	NOUN
admet-292	544	3	measurements	measurement	NOUN
admet-292	544	4	are	be	AUX
admet-292	544	5	conducted	conduct	VERB
admet-292	544	6	at	at	ADP
admet-292	544	7	different	different	ADJ
admet-292	544	8	temperatures	temperature	NOUN
admet-292	544	9	,	,	PUNCT
admet-292	544	10	it	it	PRON
admet-292	544	11	is	be	AUX
admet-292	544	12	common	common	ADJ
admet-292	544	13	to	to	PART
admet-292	544	14	report	report	VERB
admet-292	544	15	the	the	DET
admet-292	544	16	solubility	solubility	NOUN
admet-292	544	17	values	value	NOUN
admet-292	544	18	in	in	ADP
admet-292	544	19	mole	mole	ADJ
admet-292	544	20	fraction	fraction	NOUN
admet-292	544	21	,	,	PUNCT
admet-292	544	22	mass	mass	NOUN
admet-292	544	23	fraction	fraction	NOUN
admet-292	544	24	,	,	PUNCT
admet-292	544	25	and	and	CCONJ
admet-292	544	26	molality	molality	NOUN
admet-292	544	27	units	unit	NOUN
admet-292	544	28	,	,	PUNCT
admet-292	544	29	since	since	SCONJ
admet-292	544	30	these	these	PRON
admet-292	544	31	do	do	AUX
admet-292	544	32	not	not	PART
admet-292	544	33	depend	depend	VERB
admet-292	544	34	on	on	ADP
admet-292	544	35	the	the	DET
admet-292	544	36	density	density	NOUN
admet-292	544	37	of	of	ADP
admet-292	544	38	the	the	DET
admet-292	544	39	solutions	solution	NOUN
admet-292	544	40	,	,	PUNCT
admet-292	544	41	which	which	PRON
admet-292	544	42	can	can	AUX
admet-292	544	43	change	change	VERB
admet-292	544	44	with	with	ADP
admet-292	544	45	temperature	temperature	NOUN
admet-292	544	46	.	.	PUNCT
admet-292	545	1	since	since	SCONJ
admet-292	545	2	advanced	advanced	ADJ
admet-292	545	3	computational	computational	ADJ
admet-292	545	4	approaches	approach	NOUN
admet-292	545	5	to	to	PART
admet-292	545	6	evaluate	evaluate	VERB
admet-292	545	7	the	the	DET
admet-292	545	8	logs	log	NOUN
admet-292	545	9	-	-	PUNCT
admet-292	545	10	ph	ph	ADJ
admet-292	545	11	data	datum	NOUN
admet-292	545	12	are	be	AUX
admet-292	545	13	anchored	anchor	VERB
admet-292	545	14	in	in	ADP
admet-292	545	15	molarity	molarity	NOUN
admet-292	545	16	units	unit	NOUN
admet-292	545	17	,	,	PUNCT
admet-292	545	18	it	it	PRON
admet-292	545	19	would	would	AUX
admet-292	545	20	be	be	AUX
admet-292	545	21	useful	useful	ADJ
admet-292	545	22	to	to	PART
admet-292	545	23	report	report	VERB
admet-292	545	24	the	the	DET
admet-292	545	25	weight	weight	NOUN
admet-292	545	26	of	of	ADP
admet-292	545	27	a	a	DET
admet-292	545	28	certain	certain	ADJ
admet-292	545	29	volume	volume	NOUN
admet-292	545	30	of	of	ADP
admet-292	545	31	the	the	DET
admet-292	545	32	saturated	saturate	VERB
admet-292	545	33	solution	solution	NOUN
admet-292	545	34	at	at	ADP
admet-292	545	35	the	the	DET
admet-292	545	36	assay	assay	NOUN
admet-292	545	37	temperature	temperature	NOUN
admet-292	545	38	,	,	PUNCT
admet-292	545	39	after	after	SCONJ
admet-292	545	40	the	the	DET
admet-292	545	41	solid	solid	NOUN
admet-292	545	42	had	have	AUX
admet-292	545	43	been	be	AUX
admet-292	545	44	separated	separate	VERB
admet-292	545	45	from	from	ADP
admet-292	545	46	it	it	PRON
admet-292	545	47	,	,	PUNCT
admet-292	545	48	so	so	SCONJ
admet-292	545	49	that	that	SCONJ
admet-292	545	50	molality	molality	NOUN
admet-292	545	51	units	unit	NOUN
admet-292	545	52	can	can	AUX
admet-292	545	53	be	be	AUX
admet-292	545	54	converted	convert	VERB
admet-292	545	55	to	to	ADP
admet-292	545	56	those	those	PRON
admet-292	545	57	based	base	VERB
admet-292	545	58	on	on	ADP
admet-292	545	59	molarity	molarity	NOUN
admet-292	545	60	.	.	PUNCT
admet-292	546	1	recommendations	recommendation	NOUN
admet-292	546	2	for	for	ADP
admet-292	546	3	type	type	NOUN
admet-292	546	4	of	of	ADP
admet-292	546	5	solubility	solubility	NOUN
admet-292	546	6	to	to	PART
admet-292	546	7	measure	measure	VERB
admet-292	546	8	generally	generally	ADV
admet-292	546	9	,	,	PUNCT
admet-292	546	10	the	the	DET
admet-292	546	11	measurement	measurement	NOUN
admet-292	546	12	of	of	ADP
admet-292	546	13	the	the	DET
admet-292	546	14	water	water	NOUN
admet-292	546	15	solubility	solubility	PROPN
admet-292	546	16	,	,	PUNCT
admet-292	546	17	sw	sw	PROPN
admet-292	546	18	,	,	PUNCT
admet-292	546	19	can	can	AUX
admet-292	546	20	not	not	PART
admet-292	546	21	be	be	AUX
admet-292	546	22	recommended	recommend	VERB
admet-292	546	23	.	.	PUNCT
admet-292	547	1	if	if	SCONJ
admet-292	547	2	there	there	PRON
admet-292	547	3	is	be	VERB
admet-292	547	4	good	good	ADJ
admet-292	547	5	reason	reason	NOUN
admet-292	547	6	to	to	PART
admet-292	547	7	do	do	VERB
admet-292	547	8	so	so	ADV
admet-292	547	9	,	,	PUNCT
admet-292	547	10	then	then	ADV
admet-292	547	11	(	(	PUNCT
admet-292	547	12	a	a	X
admet-292	547	13	)	)	PUNCT
admet-292	547	14	use	use	NOUN
admet-292	547	15	freshly	freshly	ADV
admet-292	547	16	distilled	distil	VERB
admet-292	547	17	/	/	SYM
admet-292	547	18	purified	purify	VERB
admet-292	547	19	water	water	NOUN
admet-292	547	20	that	that	PRON
admet-292	547	21	had	have	AUX
admet-292	547	22	been	be	AUX
admet-292	547	23	allowed	allow	VERB
admet-292	547	24	to	to	PART
admet-292	547	25	equilibrate	equilibrate	VERB
admet-292	547	26	at	at	ADP
admet-292	547	27	the	the	DET
admet-292	547	28	measurement	measurement	NOUN
admet-292	547	29	temperature	temperature	NOUN
admet-292	547	30	,	,	PUNCT
admet-292	547	31	(	(	PUNCT
admet-292	547	32	b	b	X
admet-292	547	33	)	)	PUNCT
admet-292	547	34	measure	measure	NOUN
admet-292	547	35	the	the	DET
admet-292	547	36	ph	ph	NOUN
admet-292	547	37	of	of	ADP
admet-292	547	38	the	the	DET
admet-292	547	39	water	water	NOUN
admet-292	547	40	exposed	expose	VERB
admet-292	547	41	to	to	ADP
admet-292	547	42	ambient	ambient	ADJ
admet-292	547	43	air	air	NOUN
admet-292	547	44	,	,	PUNCT
admet-292	547	45	phw	phw	NOUN
admet-292	547	46	,	,	PUNCT
admet-292	547	47	before	before	ADP
admet-292	547	48	adding	add	VERB
admet-292	547	49	the	the	DET
admet-292	547	50	sample	sample	NOUN
admet-292	547	51	(	(	PUNCT
admet-292	547	52	to	to	PART
admet-292	547	53	estimate	estimate	VERB
admet-292	547	54	co2	co2	NOUN
admet-292	547	55	concentration	concentration	NOUN
admet-292	547	56	)	)	PUNCT
admet-292	547	57	,	,	PUNCT
admet-292	547	58	and	and	CCONJ
admet-292	547	59	(	(	PUNCT
admet-292	547	60	c	c	NOUN
admet-292	547	61	)	)	PUNCT
admet-292	547	62	measure	measure	NOUN
admet-292	547	63	the	the	DET
admet-292	547	64	final	final	ADJ
admet-292	547	65	phsat	phsat	NOUN
admet-292	547	66	.	.	PUNCT
admet-292	548	1	sample	sample	NOUN
admet-292	548	2	purity	purity	NOUN
admet-292	548	3	needs	need	VERB
admet-292	548	4	to	to	PART
admet-292	548	5	be	be	AUX
admet-292	548	6	verified	verify	VERB
admet-292	548	7	.	.	PUNCT
admet-292	549	1	potentiometric	potentiometric	ADJ
admet-292	549	2	methods	method	NOUN
admet-292	549	3	such	such	ADJ
admet-292	549	4	as	as	ADP
admet-292	549	5	cheqsol	cheqsol	X
admet-292	549	6	are	be	AUX
admet-292	549	7	well	well	ADV
admet-292	549	8	suited	suited	ADJ
admet-292	549	9	to	to	PART
admet-292	549	10	determine	determine	VERB
admet-292	549	11	intrinsic	intrinsic	ADJ
admet-292	549	12	solubility	solubility	NOUN
admet-292	549	13	(	(	PUNCT
admet-292	549	14	avoiding	avoid	VERB
admet-292	549	15	the	the	DET
admet-292	549	16	possible	possible	ADJ
admet-292	549	17	interferences	interference	NOUN
admet-292	549	18	due	due	ADJ
admet-292	549	19	to	to	ADP
admet-292	549	20	buffers	buffer	NOUN
admet-292	549	21	)	)	PUNCT
admet-292	549	22	,	,	PUNCT
admet-292	549	23	and	and	CCONJ
admet-292	549	24	can	can	AUX
admet-292	549	25	thus	thus	ADV
admet-292	549	26	be	be	AUX
admet-292	549	27	well	well	ADV
admet-292	549	28	recommended	recommend	VERB
admet-292	549	29	.	.	PUNCT
admet-292	550	1	multiple	multiple	ADJ
admet-292	550	2	-	-	PUNCT
admet-292	550	3	ph	ph	ADJ
admet-292	550	4	shake	shake	NOUN
admet-292	550	5	-	-	PUNCT
admet-292	550	6	flask	flask	NOUN
admet-292	550	7	assays	assay	NOUN
admet-292	550	8	are	be	AUX
admet-292	550	9	recommended	recommend	VERB
admet-292	550	10	for	for	ADP
admet-292	550	11	general	general	ADJ
admet-292	550	12	applications	application	NOUN
admet-292	550	13	,	,	PUNCT
admet-292	550	14	since	since	SCONJ
admet-292	550	15	many	many	ADJ
admet-292	550	16	different	different	ADJ
admet-292	550	17	solution	solution	NOUN
admet-292	550	18	properties	property	NOUN
admet-292	550	19	can	can	AUX
admet-292	550	20	be	be	AUX
admet-292	550	21	revealed	reveal	VERB
admet-292	550	22	by	by	ADP
admet-292	550	23	the	the	DET
admet-292	550	24	logs	log	NOUN
admet-292	550	25	-	-	PUNCT
admet-292	550	26	ph	ph	ADJ
admet-292	550	27	profiles	profile	NOUN
admet-292	550	28	.	.	PUNCT
admet-292	551	1	a	a	DET
admet-292	551	2	single	single	ADJ
admet-292	551	3	solubility	solubility	NOUN
admet-292	551	4	determination	determination	NOUN
admet-292	551	5	at	at	ADP
admet-292	551	6	a	a	DET
admet-292	551	7	measured	measured	ADJ
admet-292	551	8	ph	ph	NOUN
admet-292	551	9	can	can	AUX
admet-292	551	10	establish	establish	VERB
admet-292	551	11	the	the	DET
admet-292	551	12	intrinsic	intrinsic	ADJ
admet-292	551	13	solubility	solubility	NOUN
admet-292	551	14	.	.	PUNCT
admet-292	552	1	but	but	CCONJ
admet-292	552	2	it	it	PRON
admet-292	552	3	is	be	AUX
admet-292	552	4	recommended	recommend	VERB
admet-292	552	5	that	that	SCONJ
admet-292	552	6	at	at	ADV
admet-292	552	7	least	least	ADV
admet-292	552	8	three	three	NUM
admet-292	552	9	ph	ph	ADJ
admet-292	552	10	points	point	NOUN
admet-292	552	11	be	be	AUX
admet-292	552	12	measured	measure	VERB
admet-292	552	13	if	if	SCONJ
admet-292	552	14	the	the	DET
admet-292	552	15	intrinsic	intrinsic	ADJ
admet-292	552	16	solubility	solubility	NOUN
admet-292	552	17	is	be	AUX
admet-292	552	18	to	to	PART
admet-292	552	19	be	be	AUX
admet-292	552	20	determined	determine	VERB
admet-292	552	21	reliably	reliably	ADV
admet-292	552	22	:	:	PUNCT
admet-292	552	23	ph	ph	PROPN
admet-292	552	24	=	=	SYM
admet-292	552	25	{	{	PUNCT
admet-292	552	26	pka	pka	PROPN
admet-292	552	27	2	2	NUM
admet-292	552	28	,	,	PUNCT
admet-292	552	29	pka	pka	PROPN
admet-292	552	30	,	,	PUNCT
admet-292	552	31	pka	pka	PROPN
admet-292	552	32	+	+	PROPN
admet-292	552	33	2	2	NUM
admet-292	552	34	}	}	PUNCT
admet-292	552	35	,	,	PUNCT
admet-292	552	36	where	where	SCONJ
admet-292	552	37	pka	pka	PROPN
admet-292	552	38	is	be	AUX
admet-292	552	39	independently	independently	ADV
admet-292	552	40	determined	determine	VERB
admet-292	552	41	.	.	PUNCT
admet-292	553	1	if	if	SCONJ
admet-292	553	2	also	also	ADV
admet-292	553	3	the	the	DET
admet-292	553	4	salt	salt	NOUN
admet-292	553	5	solubility	solubility	NOUN
admet-292	553	6	is	be	AUX
admet-292	553	7	being	be	AUX
admet-292	553	8	determined	determine	VERB
admet-292	553	9	,	,	PUNCT
admet-292	553	10	then	then	ADV
admet-292	553	11	more	more	ADJ
admet-292	553	12	points	point	NOUN
admet-292	553	13	would	would	AUX
admet-292	553	14	be	be	AUX
admet-292	553	15	required	require	VERB
admet-292	553	16	:	:	PUNCT
admet-292	553	17	e.g.	e.g.	ADV
admet-292	553	18	,	,	PUNCT
admet-292	553	19	ph	ph	NOUN
admet-292	553	20	=	=	SYM
admet-292	553	21	{	{	PUNCT
admet-292	553	22	pka	pka	PROPN
admet-292	553	23	gibbs	gibbs	PROPN
admet-292	553	24	2	2	NUM
admet-292	553	25	,	,	PUNCT
admet-292	553	26	pka	pka	PROPN
admet-292	553	27	gibbs	gibbs	PROPN
admet-292	553	28	,	,	PUNCT
admet-292	553	29	pka	pka	PROPN
admet-292	553	30	gibbs	gibbs	PROPN
admet-292	553	31	+	+	CCONJ
admet-292	553	32	2	2	NUM
admet-292	553	33	}	}	PUNCT
admet-292	553	34	,	,	PUNCT
admet-292	553	35	in	in	ADP
admet-292	553	36	addition	addition	NOUN
admet-292	553	37	to	to	ADP
admet-292	553	38	those	those	DET
admet-292	553	39	points	point	NOUN
admet-292	553	40	around	around	ADP
admet-292	553	41	the	the	DET
admet-292	553	42	pka	pka	PROPN
admet-292	553	43	.	.	PUNCT
admet-292	554	1	the	the	DET
admet-292	554	2	characterization	characterization	NOUN
admet-292	554	3	of	of	ADP
admet-292	554	4	drug	drug	NOUN
admet-292	554	5	salts	salt	NOUN
admet-292	554	6	,	,	PUNCT
admet-292	554	7	aggregates	aggregate	NOUN
admet-292	554	8	/	/	SYM
admet-292	554	9	micelles	micelle	NOUN
admet-292	554	10	,	,	PUNCT
admet-292	554	11	complexes	complex	NOUN
admet-292	554	12	,	,	PUNCT
admet-292	554	13	and	and	CCONJ
admet-292	554	14	cocrystals	cocrystal	NOUN
admet-292	554	15	generally	generally	ADV
admet-292	554	16	requires	require	VERB
admet-292	554	17	multiple	multiple	ADJ
admet-292	554	18	-	-	PUNCT
admet-292	554	19	ph	ph	ADJ
admet-292	554	20	solubility	solubility	NOUN
admet-292	554	21	data	datum	NOUN
admet-292	554	22	,	,	PUNCT
admet-292	554	23	in	in	ADP
admet-292	554	24	thoughtfully	thoughtfully	ADV
admet-292	554	25	-	-	PUNCT
admet-292	554	26	designed	design	VERB
admet-292	554	27	assays	assay	NOUN
admet-292	554	28	.	.	PUNCT
admet-292	555	1	recommendation	recommendation	NOUN
admet-292	555	2	for	for	ADP
admet-292	555	3	reporting	report	VERB
admet-292	555	4	temperature	temperature	NOUN
admet-292	555	5	the	the	DET
admet-292	555	6	temperature	temperature	NOUN
admet-292	555	7	must	must	AUX
admet-292	555	8	always	always	ADV
admet-292	555	9	be	be	AUX
admet-292	555	10	measured	measure	VERB
admet-292	555	11	at	at	ADP
admet-292	555	12	the	the	DET
admet-292	555	13	time	time	NOUN
admet-292	555	14	equilibration	equilibration	NOUN
admet-292	555	15	is	be	AUX
admet-292	555	16	established	establish	VERB
admet-292	555	17	,	,	PUNCT
admet-292	555	18	and	and	CCONJ
admet-292	555	19	its	its	PRON
admet-292	555	20	value	value	NOUN
admet-292	555	21	reported	report	VERB
admet-292	555	22	in	in	ADP
admet-292	555	23	the	the	DET
admet-292	555	24	publication	publication	NOUN
admet-292	555	25	.	.	PUNCT
admet-292	556	1	the	the	DET
admet-292	556	2	method	method	NOUN
admet-292	556	3	of	of	ADP
admet-292	556	4	temperature	temperature	NOUN
admet-292	556	5	control	control	NOUN
admet-292	556	6	should	should	AUX
admet-292	556	7	be	be	AUX
admet-292	556	8	reported	report	VERB
admet-292	556	9	.	.	PUNCT
admet-292	557	1	it	it	PRON
admet-292	557	2	is	be	AUX
admet-292	557	3	not	not	PART
admet-292	557	4	helpful	helpful	ADJ
admet-292	557	5	to	to	PART
admet-292	557	6	state	state	VERB
admet-292	557	7	the	the	DET
admet-292	557	8	value	value	NOUN
admet-292	557	9	as	as	ADP
admet-292	557	10	“	"	PUNCT
admet-292	557	11	room	room	NOUN
admet-292	557	12	temperature	temperature	NOUN
admet-292	557	13	.	.	PUNCT
admet-292	557	14	”	"	PUNCT
admet-292	558	1	admet	admet	PROPN
admet-292	558	2	&	&	CCONJ
admet-292	558	3	dmpk	dmpk	PROPN
admet-292	558	4	4(2	4(2	NUM
admet-292	558	5	)	)	PUNCT
admet-292	558	6	(	(	PUNCT
admet-292	558	7	2016	2016	NUM
admet-292	558	8	)	)	PUNCT
admet-292	558	9	117	117	NUM
admet-292	558	10	-	-	SYM
admet-292	558	11	178	178	NUM
admet-292	558	12	consensus	consensus	NOUN
admet-292	558	13	recommendations	recommendation	NOUN
admet-292	558	14	for	for	ADP
admet-292	558	15	improving	improve	VERB
admet-292	558	16	solubility	solubility	NOUN
admet-292	558	17	-	-	PUNCT
admet-292	558	18	ph	ph	ADJ
admet-292	558	19	data	datum	NOUN
admet-292	558	20	quality	quality	NOUN
admet-292	558	21	doi	doi	NOUN
admet-292	558	22	:	:	PUNCT
admet-292	558	23	10.5599	10.5599	NUM
admet-292	558	24	/	/	SYM
admet-292	558	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	558	26	145	145	NUM
admet-292	558	27	ionic	ionic	ADJ
admet-292	558	28	strength	strength	NOUN
admet-292	558	29	measured	measure	VERB
admet-292	558	30	solubility	solubility	NOUN
admet-292	558	31	can	can	AUX
admet-292	558	32	be	be	AUX
admet-292	558	33	affected	affect	VERB
admet-292	558	34	by	by	ADP
admet-292	558	35	ionic	ionic	ADJ
admet-292	558	36	strength	strength	NOUN
admet-292	558	37	(	(	PUNCT
admet-292	558	38	especially	especially	ADV
admet-292	558	39	when	when	SCONJ
admet-292	558	40	salt	salt	NOUN
admet-292	558	41	solubility	solubility	NOUN
admet-292	558	42	is	be	AUX
admet-292	558	43	measured	measure	VERB
admet-292	558	44	)	)	PUNCT
admet-292	558	45	,	,	PUNCT
admet-292	558	46	so	so	CCONJ
admet-292	558	47	the	the	DET
admet-292	558	48	ionic	ionic	ADJ
admet-292	558	49	strength	strength	NOUN
admet-292	558	50	usually	usually	ADV
admet-292	558	51	needs	need	VERB
admet-292	558	52	to	to	PART
admet-292	558	53	be	be	AUX
admet-292	558	54	reported	report	VERB
admet-292	558	55	.	.	PUNCT
admet-292	559	1	the	the	DET
admet-292	559	2	average	average	ADJ
admet-292	559	3	total	total	ADJ
admet-292	559	4	ionic	ionic	ADJ
admet-292	559	5	strength	strength	NOUN
admet-292	559	6	needs	need	VERB
admet-292	559	7	to	to	PART
admet-292	559	8	be	be	AUX
admet-292	559	9	calculated	calculate	VERB
admet-292	559	10	from	from	ADP
admet-292	559	11	the	the	DET
admet-292	559	12	contributions	contribution	NOUN
admet-292	559	13	at	at	ADP
admet-292	559	14	each	each	DET
admet-292	559	15	ph	ph	ADJ
admet-292	559	16	point	point	NOUN
admet-292	559	17	.	.	PUNCT
admet-292	560	1	it	it	PRON
admet-292	560	2	is	be	AUX
admet-292	560	3	the	the	DET
admet-292	560	4	ph	ph	ADJ
admet-292	560	5	-	-	ADJ
admet-292	560	6	dependent	dependent	ADJ
admet-292	560	7	sum	sum	NOUN
admet-292	560	8	of	of	ADP
admet-292	560	9	the	the	DET
admet-292	560	10	contributions	contribution	NOUN
admet-292	560	11	of	of	ADP
admet-292	560	12	inert	inert	ADJ
admet-292	560	13	background	background	NOUN
admet-292	560	14	electrolytes	electrolyte	NOUN
admet-292	560	15	(	(	PUNCT
admet-292	560	16	nacl	nacl	NOUN
admet-292	560	17	,	,	PUNCT
admet-292	560	18	kcl	kcl	PROPN
admet-292	560	19	,	,	PUNCT
admet-292	560	20	etc	etc	X
admet-292	560	21	.	.	X
admet-292	560	22	)	)	PUNCT
admet-292	560	23	,	,	PUNCT
admet-292	560	24	buffer	buffer	VERB
admet-292	560	25	constituents	constituent	NOUN
admet-292	560	26	,	,	PUNCT
admet-292	560	27	as	as	ADV
admet-292	560	28	well	well	ADV
admet-292	560	29	as	as	ADP
admet-292	560	30	the	the	DET
admet-292	560	31	sample	sample	NOUN
admet-292	560	32	(	(	PUNCT
admet-292	560	33	especially	especially	ADV
admet-292	560	34	when	when	SCONJ
admet-292	560	35	introduced	introduce	VERB
admet-292	560	36	in	in	ADP
admet-292	560	37	salt	salt	NOUN
admet-292	560	38	form	form	NOUN
admet-292	560	39	)	)	PUNCT
admet-292	560	40	.	.	PUNCT
admet-292	561	1	it	it	PRON
admet-292	561	2	is	be	AUX
admet-292	561	3	not	not	PART
admet-292	561	4	possible	possible	ADJ
admet-292	561	5	to	to	PART
admet-292	561	6	back	back	NOUN
admet-292	561	7	-	-	PUNCT
admet-292	561	8	calculate	calculate	VERB
admet-292	561	9	the	the	DET
admet-292	561	10	ionic	ionic	ADJ
admet-292	561	11	strength	strength	NOUN
admet-292	561	12	at	at	ADP
admet-292	561	13	each	each	DET
admet-292	561	14	ph	ph	NOUN
admet-292	561	15	point	point	NOUN
admet-292	561	16	if	if	SCONJ
admet-292	561	17	the	the	DET
admet-292	561	18	report	report	NOUN
admet-292	561	19	simply	simply	ADV
admet-292	561	20	states	state	VERB
admet-292	561	21	that	that	SCONJ
admet-292	561	22	“	"	PUNCT
admet-292	561	23	buffers	buffer	NOUN
admet-292	561	24	were	be	AUX
admet-292	561	25	used	use	VERB
admet-292	561	26	”	"	PUNCT
admet-292	561	27	or	or	CCONJ
admet-292	561	28	“	"	PUNCT
admet-292	561	29	measurement	measurement	NOUN
admet-292	561	30	was	be	AUX
admet-292	561	31	done	do	VERB
admet-292	561	32	in	in	ADP
admet-292	561	33	water	water	NOUN
admet-292	561	34	.	.	PUNCT
admet-292	561	35	”	"	PUNCT
admet-292	562	1	measurement	measurement	NOUN
admet-292	562	2	of	of	ADP
admet-292	562	3	ph	ph	NOUN
admet-292	562	4	using	use	VERB
admet-292	562	5	glass	glass	NOUN
admet-292	562	6	electrodes	electrode	VERB
admet-292	562	7	a	a	DET
admet-292	562	8	ph	ph	ADJ
admet-292	562	9	electrode	electrode	NOUN
admet-292	562	10	is	be	AUX
admet-292	562	11	a	a	DET
admet-292	562	12	sensitive	sensitive	ADJ
admet-292	562	13	electrochemical	electrochemical	ADJ
admet-292	562	14	probe	probe	NOUN
admet-292	562	15	that	that	PRON
admet-292	562	16	can	can	AUX
admet-292	562	17	indicate	indicate	VERB
admet-292	562	18	the	the	DET
admet-292	562	19	degree	degree	NOUN
admet-292	562	20	of	of	ADP
admet-292	562	21	acidity	acidity	NOUN
admet-292	562	22	of	of	ADP
admet-292	562	23	a	a	DET
admet-292	562	24	solution	solution	NOUN
admet-292	562	25	.	.	PUNCT
admet-292	563	1	the	the	DET
admet-292	563	2	device	device	NOUN
admet-292	563	3	is	be	AUX
admet-292	563	4	a	a	DET
admet-292	563	5	combination	combination	NOUN
admet-292	563	6	of	of	ADP
admet-292	563	7	a	a	DET
admet-292	563	8	reference	reference	NOUN
admet-292	563	9	half	half	ADJ
admet-292	563	10	-	-	PUNCT
admet-292	563	11	cell	cell	NOUN
admet-292	563	12	(	(	PUNCT
admet-292	563	13	in	in	ADP
admet-292	563	14	a	a	DET
admet-292	563	15	compartment	compartment	NOUN
admet-292	563	16	separated	separate	VERB
admet-292	563	17	from	from	ADP
admet-292	563	18	the	the	DET
admet-292	563	19	test	test	NOUN
admet-292	563	20	solution	solution	NOUN
admet-292	563	21	by	by	ADP
admet-292	563	22	a	a	DET
admet-292	563	23	porous	porous	ADJ
admet-292	563	24	-	-	PUNCT
admet-292	563	25	barrier	barrier	NOUN
admet-292	563	26	junction	junction	NOUN
admet-292	563	27	that	that	PRON
admet-292	563	28	permits	permit	VERB
admet-292	563	29	the	the	DET
admet-292	563	30	flow	flow	NOUN
admet-292	563	31	of	of	ADP
admet-292	563	32	an	an	DET
admet-292	563	33	ionic	ionic	ADJ
admet-292	563	34	current	current	NOUN
admet-292	563	35	but	but	CCONJ
admet-292	563	36	prevents	prevent	VERB
admet-292	563	37	convective	convective	ADJ
admet-292	563	38	mixing	mixing	NOUN
admet-292	563	39	of	of	ADP
admet-292	563	40	the	the	DET
admet-292	563	41	reference	reference	NOUN
admet-292	563	42	and	and	CCONJ
admet-292	563	43	the	the	DET
admet-292	563	44	test	test	NOUN
admet-292	563	45	solutions	solution	NOUN
admet-292	563	46	)	)	PUNCT
admet-292	563	47	and	and	CCONJ
admet-292	563	48	a	a	DET
admet-292	563	49	ph	ph	ADJ
admet-292	563	50	-	-	PUNCT
admet-292	563	51	sensing	sense	VERB
admet-292	563	52	glass	glass	NOUN
admet-292	563	53	electrode	electrode	NOUN
admet-292	563	54	half	half	ADJ
admet-292	563	55	-	-	PUNCT
admet-292	563	56	cell	cell	NOUN
admet-292	563	57	.	.	PUNCT
admet-292	564	1	the	the	DET
admet-292	564	2	two	two	NUM
admet-292	564	3	half	half	NOUN
admet-292	564	4	cells	cell	NOUN
admet-292	564	5	immersed	immerse	VERB
admet-292	564	6	in	in	ADP
admet-292	564	7	the	the	DET
admet-292	564	8	test	test	NOUN
admet-292	564	9	solution	solution	NOUN
admet-292	564	10	complete	complete	VERB
admet-292	564	11	the	the	DET
admet-292	564	12	electrical	electrical	ADJ
admet-292	564	13	circuit	circuit	NOUN
admet-292	564	14	,	,	PUNCT
admet-292	564	15	as	as	ADP
admet-292	564	16	a	a	DET
admet-292	564	17	high	high	ADJ
admet-292	564	18	impedance	impedance	NOUN
admet-292	564	19	(	(	PUNCT
admet-292	564	20	i.e.	i.e.	X
admet-292	564	21	,	,	PUNCT
admet-292	564	22	extremely	extremely	ADV
admet-292	564	23	low	low	ADJ
admet-292	564	24	electrical	electrical	ADJ
admet-292	564	25	current	current	ADJ
admet-292	564	26	)	)	PUNCT
admet-292	564	27	voltage	voltage	NOUN
admet-292	564	28	is	be	AUX
admet-292	564	29	measured	measure	VERB
admet-292	564	30	,	,	PUNCT
admet-292	564	31	which	which	PRON
admet-292	564	32	is	be	AUX
admet-292	564	33	proportional	proportional	ADJ
admet-292	564	34	to	to	ADP
admet-292	564	35	ph	ph	PROPN
admet-292	564	36	of	of	ADP
admet-292	564	37	the	the	DET
admet-292	564	38	solution	solution	NOUN
admet-292	564	39	.	.	PUNCT
admet-292	565	1	such	such	DET
admet-292	565	2	a	a	DET
admet-292	565	3	system	system	NOUN
admet-292	565	4	needs	need	VERB
admet-292	565	5	to	to	PART
admet-292	565	6	be	be	AUX
admet-292	565	7	calibrated	calibrate	VERB
admet-292	565	8	against	against	ADP
admet-292	565	9	solutions	solution	NOUN
admet-292	565	10	of	of	ADP
admet-292	565	11	defined	define	VERB
admet-292	565	12	ph	ph	NOUN
admet-292	565	13	,	,	PUNCT
admet-292	565	14	so	so	SCONJ
admet-292	565	15	that	that	SCONJ
admet-292	565	16	the	the	DET
admet-292	565	17	measured	measure	VERB
admet-292	565	18	voltage	voltage	NOUN
admet-292	565	19	can	can	AUX
admet-292	565	20	be	be	AUX
admet-292	565	21	converted	convert	VERB
admet-292	565	22	to	to	ADP
admet-292	565	23	the	the	DET
admet-292	565	24	“	"	PUNCT
admet-292	565	25	operational	operational	ADJ
admet-292	565	26	”	"	PUNCT
admet-292	565	27	ph	ph	ADJ
admet-292	565	28	scale	scale	NOUN
admet-292	565	29	.	.	PUNCT
admet-292	566	1	the	the	DET
admet-292	566	2	latter	latter	ADJ
admet-292	566	3	is	be	AUX
admet-292	566	4	nearly	nearly	ADV
admet-292	566	5	,	,	PUNCT
admet-292	566	6	but	but	CCONJ
admet-292	566	7	not	not	PART
admet-292	566	8	precisely	precisely	ADV
admet-292	566	9	,	,	PUNCT
admet-292	566	10	the	the	DET
admet-292	566	11	activity	activity	NOUN
admet-292	566	12	scale	scale	NOUN
admet-292	566	13	,	,	PUNCT
admet-292	566	14	pah	pah	PROPN
admet-292	567	1	[	[	X
admet-292	567	2	27	27	NUM
admet-292	567	3	]	]	PUNCT
admet-292	567	4	.	.	PUNCT
admet-292	568	1	the	the	DET
admet-292	568	2	relationship	relationship	NOUN
admet-292	568	3	between	between	ADP
admet-292	568	4	voltage	voltage	NOUN
admet-292	568	5	and	and	CCONJ
admet-292	568	6	the	the	DET
admet-292	568	7	operational	operational	ADJ
admet-292	568	8	ph	ph	NOUN
admet-292	568	9	depends	depend	VERB
admet-292	568	10	on	on	ADP
admet-292	568	11	temperature	temperature	NOUN
admet-292	568	12	and	and	CCONJ
admet-292	568	13	ionic	ionic	ADJ
admet-292	568	14	strength	strength	NOUN
admet-292	568	15	.	.	PUNCT
admet-292	569	1	for	for	ADP
admet-292	569	2	common	common	ADJ
admet-292	569	3	laboratory	laboratory	NOUN
admet-292	569	4	use	use	NOUN
admet-292	569	5	,	,	PUNCT
admet-292	569	6	the	the	DET
admet-292	569	7	ph	ph	ADJ
admet-292	569	8	electrodes	electrode	NOUN
admet-292	569	9	are	be	AUX
admet-292	569	10	typically	typically	ADV
admet-292	569	11	calibrated	calibrate	VERB
admet-292	569	12	against	against	ADP
admet-292	569	13	standard	standard	NOUN
admet-292	569	14	(	(	PUNCT
admet-292	569	15	“	"	PUNCT
admet-292	569	16	nist	nist	NOUN
admet-292	569	17	-	-	PUNCT
admet-292	569	18	traceable	traceable	ADJ
admet-292	569	19	”	"	PUNCT
admet-292	569	20	)	)	PUNCT
admet-292	569	21	ph	ph	NOUN
admet-292	569	22	4.00	4.00	NUM
admet-292	569	23	(	(	PUNCT
admet-292	569	24	phthalate	phthalate	NOUN
admet-292	569	25	)	)	PUNCT
admet-292	569	26	and	and	CCONJ
admet-292	569	27	7.00	7.00	NUM
admet-292	569	28	(	(	PUNCT
admet-292	569	29	phosphate	phosphate	NOUN
admet-292	569	30	)	)	PUNCT
admet-292	569	31	buffers	buffer	NOUN
admet-292	569	32	,	,	PUNCT
admet-292	569	33	with	with	ADP
admet-292	569	34	ionic	ionic	ADJ
admet-292	569	35	strength	strength	NOUN
admet-292	569	36	of	of	ADP
admet-292	569	37	0.10	0.10	NUM
admet-292	569	38	m.	m.	NOUN
admet-292	569	39	however	however	ADV
admet-292	569	40	this	this	DET
admet-292	569	41	procedure	procedure	NOUN
admet-292	569	42	may	may	AUX
admet-292	569	43	be	be	AUX
admet-292	569	44	inadequate	inadequate	ADJ
admet-292	569	45	for	for	ADP
admet-292	569	46	specialized	specialized	ADJ
admet-292	569	47	applications	application	NOUN
admet-292	569	48	,	,	PUNCT
admet-292	569	49	such	such	ADJ
admet-292	569	50	as	as	ADP
admet-292	569	51	pka	pka	PROPN
admet-292	569	52	determination	determination	NOUN
admet-292	569	53	and	and	CCONJ
admet-292	569	54	solubility	solubility	NOUN
admet-292	569	55	-	-	PUNCT
admet-292	569	56	ph	ph	ADJ
admet-292	569	57	measurement	measurement	NOUN
admet-292	569	58	.	.	PUNCT
admet-292	570	1	solubility	solubility	NOUN
admet-292	570	2	determination	determination	NOUN
admet-292	570	3	may	may	AUX
admet-292	570	4	involve	involve	VERB
admet-292	570	5	measuring	measure	VERB
admet-292	570	6	ph	ph	NOUN
admet-292	570	7	in	in	ADP
admet-292	570	8	solutions	solution	NOUN
admet-292	570	9	with	with	ADP
admet-292	570	10	near	near	ADP
admet-292	570	11	zero	zero	NUM
admet-292	570	12	ionic	ionic	ADJ
admet-292	570	13	strength	strength	NOUN
admet-292	570	14	or	or	CCONJ
admet-292	570	15	ionic	ionic	ADJ
admet-292	570	16	strength	strength	NOUN
admet-292	570	17	as	as	ADV
admet-292	570	18	high	high	ADJ
admet-292	570	19	as	as	ADP
admet-292	570	20	1	1	NUM
admet-292	570	21	m	m	NOUN
admet-292	570	22	,	,	PUNCT
admet-292	570	23	far	far	ADV
admet-292	570	24	from	from	ADP
admet-292	570	25	the	the	DET
admet-292	570	26	0.1	0.1	NUM
admet-292	570	27	m	m	NOUN
admet-292	570	28	value	value	NOUN
admet-292	570	29	of	of	ADP
admet-292	570	30	the	the	DET
admet-292	570	31	calibrating	calibrate	VERB
admet-292	570	32	buffers	buffer	NOUN
admet-292	570	33	.	.	PUNCT
admet-292	571	1	the	the	DET
admet-292	571	2	reference	reference	NOUN
admet-292	571	3	electrode	electrode	VERB
admet-292	571	4	part	part	NOUN
admet-292	571	5	of	of	ADP
admet-292	571	6	the	the	DET
admet-292	571	7	circuit	circuit	NOUN
admet-292	571	8	can	can	AUX
admet-292	571	9	develop	develop	VERB
admet-292	571	10	significant	significant	ADJ
admet-292	571	11	porous	porous	ADJ
admet-292	571	12	-	-	PUNCT
admet-292	571	13	barrier	barrier	NOUN
admet-292	571	14	junction	junction	NOUN
admet-292	571	15	voltages	voltage	NOUN
admet-292	571	16	(	(	PUNCT
admet-292	571	17	“	"	PUNCT
admet-292	571	18	liquid	liquid	ADJ
admet-292	571	19	junction	junction	NOUN
admet-292	571	20	potentials	potential	VERB
admet-292	571	21	,	,	PUNCT
admet-292	571	22	”	"	PUNCT
admet-292	571	23	ljp	ljp	NOUN
admet-292	571	24	)	)	PUNCT
admet-292	571	25	when	when	SCONJ
admet-292	571	26	immersed	immerse	VERB
admet-292	571	27	in	in	ADP
admet-292	571	28	solutions	solution	NOUN
admet-292	571	29	with	with	ADP
admet-292	571	30	near	near	ADP
admet-292	571	31	zero	zero	NUM
admet-292	571	32	ionic	ionic	ADJ
admet-292	571	33	strength	strength	NOUN
admet-292	571	34	or	or	CCONJ
admet-292	571	35	with	with	ADP
admet-292	571	36	ph	ph	NOUN
admet-292	571	37	<	<	X
admet-292	571	38	2	2	NUM
admet-292	571	39	.	.	PUNCT
admet-292	572	1	also	also	ADV
admet-292	572	2	,	,	PUNCT
admet-292	572	3	the	the	DET
admet-292	572	4	glass	glass	NOUN
admet-292	572	5	bulb	bulb	NOUN
admet-292	572	6	of	of	ADP
admet-292	572	7	the	the	DET
admet-292	572	8	sensor	sensor	NOUN
admet-292	572	9	can	can	AUX
admet-292	572	10	develop	develop	VERB
admet-292	572	11	mechanical	mechanical	ADJ
admet-292	572	12	stress	stress	NOUN
admet-292	572	13	when	when	SCONJ
admet-292	572	14	dipped	dip	VERB
admet-292	572	15	in	in	ADP
admet-292	572	16	strongly	strongly	ADV
admet-292	572	17	acid	acid	ADJ
admet-292	572	18	solutions	solution	NOUN
admet-292	572	19	(	(	PUNCT
admet-292	572	20	ph<1	ph<1	PROPN
admet-292	572	21	)	)	PUNCT
admet-292	572	22	.	.	PUNCT
admet-292	573	1	both	both	DET
admet-292	573	2	effects	effect	NOUN
admet-292	573	3	contribute	contribute	VERB
admet-292	573	4	to	to	ADP
admet-292	573	5	an	an	DET
admet-292	573	6	error	error	NOUN
admet-292	573	7	in	in	ADP
admet-292	573	8	ph	ph	ADJ
admet-292	573	9	reading	reading	NOUN
admet-292	573	10	,	,	PUNCT
admet-292	573	11	which	which	PRON
admet-292	573	12	can	can	AUX
admet-292	573	13	be	be	AUX
admet-292	573	14	as	as	ADV
admet-292	573	15	high	high	ADJ
admet-292	573	16	as	as	ADP
admet-292	573	17	a	a	DET
admet-292	573	18	ph	ph	ADJ
admet-292	573	19	unit	unit	NOUN
admet-292	573	20	[	[	X
admet-292	573	21	4	4	NUM
admet-292	573	22	]	]	PUNCT
admet-292	573	23	.	.	PUNCT
admet-292	574	1	in	in	ADP
admet-292	574	2	published	publish	VERB
admet-292	574	3	solubility	solubility	NOUN
admet-292	574	4	studies	study	NOUN
admet-292	574	5	,	,	PUNCT
admet-292	574	6	the	the	DET
admet-292	574	7	electrode	electrode	NOUN
admet-292	574	8	calibration	calibration	NOUN
admet-292	574	9	is	be	AUX
admet-292	574	10	virtually	virtually	ADV
admet-292	574	11	never	never	ADV
admet-292	574	12	described	describe	VERB
admet-292	574	13	and	and	CCONJ
admet-292	574	14	the	the	DET
admet-292	574	15	brand	brand	NOUN
admet-292	574	16	of	of	ADP
admet-292	574	17	recommendation	recommendation	NOUN
admet-292	574	18	for	for	ADP
admet-292	574	19	reporting	report	VERB
admet-292	574	20	ionic	ionic	ADJ
admet-292	574	21	strength	strength	NOUN
admet-292	574	22	the	the	DET
admet-292	574	23	total	total	ADJ
admet-292	574	24	ionic	ionic	ADJ
admet-292	574	25	strength	strength	NOUN
admet-292	574	26	,	,	PUNCT
admet-292	574	27	averaged	average	VERB
admet-292	574	28	over	over	ADP
admet-292	574	29	the	the	DET
admet-292	574	30	ph	ph	ADJ
admet-292	574	31	range	range	NOUN
admet-292	574	32	of	of	ADP
admet-292	574	33	the	the	DET
admet-292	574	34	assay	assay	NOUN
admet-292	574	35	,	,	PUNCT
admet-292	574	36	needs	need	VERB
admet-292	574	37	to	to	PART
admet-292	574	38	be	be	AUX
admet-292	574	39	reported	report	VERB
admet-292	574	40	.	.	PUNCT
admet-292	575	1	if	if	SCONJ
admet-292	575	2	the	the	DET
admet-292	575	3	computer	computer	NOUN
admet-292	575	4	program	program	NOUN
admet-292	575	5	used	use	VERB
admet-292	575	6	to	to	PART
admet-292	575	7	evaluate	evaluate	VERB
admet-292	575	8	the	the	DET
admet-292	575	9	logs	log	NOUN
admet-292	575	10	-	-	PUNCT
admet-292	575	11	ph	ph	ADJ
admet-292	575	12	data	datum	NOUN
admet-292	575	13	does	do	AUX
admet-292	575	14	not	not	PART
admet-292	575	15	calculate	calculate	VERB
admet-292	575	16	the	the	DET
admet-292	575	17	ionic	ionic	ADJ
admet-292	575	18	strength	strength	NOUN
admet-292	575	19	,	,	PUNCT
admet-292	575	20	then	then	ADV
admet-292	575	21	the	the	DET
admet-292	575	22	report	report	NOUN
admet-292	575	23	must	must	AUX
admet-292	575	24	give	give	VERB
admet-292	575	25	enough	enough	ADJ
admet-292	575	26	information	information	NOUN
admet-292	575	27	about	about	ADP
admet-292	575	28	the	the	DET
admet-292	575	29	solution	solution	NOUN
admet-292	575	30	composition	composition	NOUN
admet-292	575	31	so	so	SCONJ
admet-292	575	32	that	that	SCONJ
admet-292	575	33	the	the	DET
admet-292	575	34	average	average	ADJ
admet-292	575	35	total	total	ADJ
admet-292	575	36	ionic	ionic	ADJ
admet-292	575	37	strength	strength	NOUN
admet-292	575	38	can	can	AUX
admet-292	575	39	be	be	AUX
admet-292	575	40	independently	independently	ADV
admet-292	575	41	calculated	calculate	VERB
admet-292	575	42	–	–	PUNCT
admet-292	575	43	i.e.	i.e.	X
admet-292	575	44	,	,	PUNCT
admet-292	575	45	precisely	precisely	ADV
admet-292	575	46	state	state	NOUN
admet-292	575	47	:	:	PUNCT
admet-292	575	48	(	(	PUNCT
admet-292	575	49	a	a	X
admet-292	575	50	)	)	PUNCT
admet-292	575	51	concentration	concentration	NOUN
admet-292	575	52	and	and	CCONJ
admet-292	575	53	type	type	NOUN
admet-292	575	54	of	of	ADP
admet-292	575	55	ionic	ionic	ADJ
admet-292	575	56	strength	strength	NOUN
admet-292	575	57	adjustor	adjustor	NOUN
admet-292	575	58	used	use	VERB
admet-292	575	59	(	(	PUNCT
admet-292	575	60	e.g.	e.g.	ADV
admet-292	575	61	,	,	PUNCT
admet-292	575	62	0.15	0.15	NUM
admet-292	575	63	m	m	NOUN
admet-292	575	64	nacl	nacl	ADJ
admet-292	575	65	)	)	PUNCT
admet-292	575	66	,	,	PUNCT
admet-292	575	67	(	(	PUNCT
admet-292	575	68	b	b	X
admet-292	575	69	)	)	PUNCT
admet-292	575	70	precise	precise	ADJ
admet-292	575	71	stoichiometry	stoichiometry	NOUN
admet-292	575	72	and	and	CCONJ
admet-292	575	73	weights	weight	NOUN
admet-292	575	74	of	of	ADP
admet-292	575	75	buffer	buffer	NOUN
admet-292	575	76	used	use	VERB
admet-292	575	77	(	(	PUNCT
admet-292	575	78	e.g.	e.g.	ADV
admet-292	575	79	,	,	PUNCT
admet-292	575	80	na2hpo4.12h2o	na2hpo4.12h2o	NOUN
admet-292	575	81	,	,	PUNCT
admet-292	575	82	not	not	PART
admet-292	575	83	just	just	ADV
admet-292	575	84	“	"	PUNCT
admet-292	575	85	sodium	sodium	NOUN
admet-292	575	86	phosphate	phosphate	NOUN
admet-292	575	87	”	"	PUNCT
admet-292	575	88	)	)	PUNCT
admet-292	575	89	,	,	PUNCT
admet-292	575	90	(	(	PUNCT
admet-292	575	91	c	c	X
admet-292	575	92	)	)	PUNCT
admet-292	575	93	weight	weight	NOUN
admet-292	575	94	and	and	CCONJ
admet-292	575	95	form	form	NOUN
admet-292	575	96	of	of	ADP
admet-292	575	97	sample	sample	NOUN
admet-292	575	98	used	use	VERB
admet-292	575	99	(	(	PUNCT
admet-292	575	100	e.g.	e.g.	ADV
admet-292	575	101	,	,	PUNCT
admet-292	575	102	amiodarone	amiodarone	NOUN
admet-292	575	103	hydrochloride	hydrochloride	NOUN
admet-292	575	104	)	)	PUNCT
admet-292	575	105	,	,	PUNCT
admet-292	575	106	(	(	PUNCT
admet-292	575	107	d	d	X
admet-292	575	108	)	)	PUNCT
admet-292	575	109	any	any	DET
admet-292	575	110	other	other	ADJ
admet-292	575	111	relevant	relevant	ADJ
admet-292	575	112	electrolytes	electrolyte	NOUN
admet-292	575	113	that	that	PRON
admet-292	575	114	would	would	AUX
admet-292	575	115	contribute	contribute	VERB
admet-292	575	116	to	to	ADP
admet-292	575	117	the	the	DET
admet-292	575	118	ionic	ionic	ADJ
admet-292	575	119	strength	strength	NOUN
admet-292	575	120	calculation	calculation	NOUN
admet-292	575	121	.	.	PUNCT
admet-292	576	1	alex	alex	PROPN
admet-292	576	2	avdeef	avdeef	PROPN
admet-292	576	3	et	et	PROPN
admet-292	576	4	al	al	PROPN
admet-292	576	5	.	.	PROPN
admet-292	576	6	admet	admet	PROPN
admet-292	576	7	&	&	CCONJ
admet-292	576	8	dmpk	dmpk	PROPN
admet-292	576	9	4(2	4(2	NUM
admet-292	576	10	)	)	PUNCT
admet-292	576	11	(	(	PUNCT
admet-292	576	12	2016	2016	NUM
admet-292	576	13	)	)	PUNCT
admet-292	576	14	117	117	NUM
admet-292	576	15	-	-	SYM
admet-292	576	16	178	178	NUM
admet-292	576	17	146	146	NUM
admet-292	576	18	electrode	electrode	NOUN
admet-292	576	19	used	use	VERB
admet-292	576	20	is	be	AUX
admet-292	576	21	largely	largely	ADV
admet-292	576	22	unidentified	unidentified	ADJ
admet-292	576	23	.	.	PUNCT
admet-292	577	1	in	in	ADP
admet-292	577	2	contrast	contrast	NOUN
admet-292	577	3	,	,	PUNCT
admet-292	577	4	attention	attention	NOUN
admet-292	577	5	to	to	ADP
admet-292	577	6	such	such	ADJ
admet-292	577	7	detail	detail	NOUN
admet-292	577	8	is	be	AUX
admet-292	577	9	the	the	DET
admet-292	577	10	norm	norm	NOUN
admet-292	577	11	in	in	ADP
admet-292	577	12	pka	pka	PROPN
admet-292	577	13	determination	determination	NOUN
admet-292	577	14	practice	practice	NOUN
admet-292	577	15	,	,	PUNCT
admet-292	577	16	where	where	SCONJ
admet-292	577	17	specialized	specialized	ADJ
admet-292	577	18	calibration	calibration	NOUN
admet-292	577	19	methods	method	NOUN
admet-292	577	20	are	be	AUX
admet-292	577	21	well	well	ADV
admet-292	577	22	developed	developed	ADJ
admet-292	577	23	[	[	X
admet-292	577	24	22	22	NUM
admet-292	577	25	,	,	PUNCT
admet-292	577	26	27	27	NUM
admet-292	577	27	,	,	PUNCT
admet-292	577	28	44	44	NUM
admet-292	577	29	,	,	PUNCT
admet-292	577	30	45	45	NUM
admet-292	577	31	,	,	PUNCT
admet-292	577	32	111	111	NUM
admet-292	577	33	-	-	SYM
admet-292	577	34	113	113	NUM
admet-292	577	35	]	]	PUNCT
admet-292	577	36	.	.	PUNCT
admet-292	578	1	researchers	researcher	NOUN
admet-292	578	2	who	who	PRON
admet-292	578	3	determine	determine	VERB
admet-292	578	4	pka	pka	PROPN
admet-292	578	5	values	value	NOUN
admet-292	578	6	using	use	VERB
admet-292	578	7	commercial	commercial	ADJ
admet-292	578	8	analyzers	analyzer	NOUN
admet-292	578	9	are	be	AUX
admet-292	578	10	well	well	ADV
admet-292	578	11	acquainted	acquainted	ADJ
admet-292	578	12	with	with	ADP
admet-292	578	13	the	the	DET
admet-292	578	14	four	four	NUM
admet-292	578	15	-	-	PUNCT
admet-292	578	16	parameter	parameter	NOUN
admet-292	578	17	electrode	electrode	NOUN
admet-292	578	18	standardization	standardization	NOUN
admet-292	578	19	procedure	procedure	NOUN
admet-292	578	20	,	,	PUNCT
admet-292	578	21	described	describe	VERB
admet-292	578	22	in	in	ADP
admet-292	578	23	appendix	appendix	ADJ
admet-292	578	24	c.	c.	NOUN
admet-292	578	25	those	those	PRON
admet-292	578	26	using	use	VERB
admet-292	578	27	the	the	DET
admet-292	578	28	sirius	sirius	PROPN
admet-292	578	29	analytical	analytical	ADJ
admet-292	578	30	titrators	titrator	NOUN
admet-292	578	31	will	will	AUX
admet-292	578	32	recognize	recognize	VERB
admet-292	578	33	the	the	DET
admet-292	578	34	procedure	procedure	NOUN
admet-292	578	35	as	as	ADP
admet-292	578	36	the	the	DET
admet-292	578	37	“	"	PUNCT
admet-292	578	38	four	four	NUM
admet-292	578	39	-	-	PUNCT
admet-292	578	40	plus	plus	NOUN
admet-292	578	41	”	"	PUNCT
admet-292	578	42	method	method	NOUN
admet-292	578	43	,	,	PUNCT
admet-292	578	44	and	and	CCONJ
admet-292	578	45	those	those	PRON
admet-292	578	46	using	use	VERB
admet-292	578	47	the	the	DET
admet-292	578	48	pion	pion	NOUN
admet-292	578	49	titrators	titrator	NOUN
admet-292	578	50	will	will	AUX
admet-292	578	51	recognize	recognize	VERB
admet-292	578	52	it	it	PRON
admet-292	578	53	as	as	ADP
admet-292	578	54	the	the	DET
admet-292	578	55	“	"	PUNCT
admet-292	578	56	abc	abc	PROPN
admet-292	578	57	”	"	PUNCT
admet-292	578	58	method	method	NOUN
admet-292	578	59	.	.	PUNCT
admet-292	579	1	buffers	buffer	NOUN
admet-292	579	2	a	a	DET
admet-292	579	3	ph	ph	ADJ
admet-292	579	4	buffer	buffer	NOUN
admet-292	579	5	is	be	AUX
admet-292	579	6	a	a	DET
admet-292	579	7	solution	solution	NOUN
admet-292	579	8	which	which	PRON
admet-292	579	9	resists	resist	VERB
admet-292	579	10	ph	ph	ADJ
admet-292	579	11	change	change	NOUN
admet-292	579	12	when	when	SCONJ
admet-292	579	13	a	a	DET
admet-292	579	14	small	small	ADJ
admet-292	579	15	quantity	quantity	NOUN
admet-292	579	16	of	of	ADP
admet-292	579	17	an	an	DET
admet-292	579	18	acid	acid	NOUN
admet-292	579	19	or	or	CCONJ
admet-292	579	20	a	a	DET
admet-292	579	21	base	base	NOUN
admet-292	579	22	is	be	AUX
admet-292	579	23	added	add	VERB
admet-292	579	24	to	to	ADP
admet-292	579	25	it	it	PRON
admet-292	579	26	.	.	PUNCT
admet-292	580	1	for	for	ADP
admet-292	580	2	example	example	NOUN
admet-292	580	3	,	,	PUNCT
admet-292	580	4	a	a	DET
admet-292	580	5	50	50	NUM
admet-292	580	6	mm	mm	NOUN
admet-292	580	7	phosphate	phosphate	NOUN
admet-292	580	8	buffer	buffer	NOUN
admet-292	580	9	solution	solution	NOUN
admet-292	580	10	at	at	ADP
admet-292	580	11	ph	ph	PROPN
admet-292	580	12	6.8	6.8	NUM
admet-292	580	13	has	have	VERB
admet-292	580	14	a	a	DET
admet-292	580	15	“	"	PUNCT
admet-292	580	16	buffer	buffer	NOUN
admet-292	580	17	capacity	capacity	NOUN
admet-292	580	18	”	"	PUNCT
admet-292	580	19	of	of	ADP
admet-292	580	20	27	27	NUM
admet-292	580	21	mm	mm	NOUN
admet-292	580	22	/	/	SYM
admet-292	580	23	ph	ph	PROPN
admet-292	580	24	.	.	PROPN
admet-292	580	25	that	that	ADV
admet-292	580	26	is	be	AUX
admet-292	580	27	,	,	PUNCT
admet-292	580	28	to	to	PART
admet-292	580	29	change	change	VERB
admet-292	580	30	ph	ph	NOUN
admet-292	580	31	of	of	ADP
admet-292	580	32	a	a	DET
admet-292	580	33	1	1	NUM
admet-292	580	34	ml	ml	NOUN
admet-292	580	35	buffer	buffer	NOUN
admet-292	580	36	solution	solution	NOUN
admet-292	580	37	from	from	ADP
admet-292	580	38	6.8	6.8	NUM
admet-292	580	39	to	to	ADP
admet-292	580	40	6.7	6.7	NUM
admet-292	580	41	,	,	PUNCT
admet-292	580	42	it	it	PRON
admet-292	580	43	would	would	AUX
admet-292	580	44	take	take	VERB
admet-292	580	45	5.4	5.4	NUM
admet-292	580	46	μl	μl	ADP
admet-292	580	47	of	of	ADP
admet-292	580	48	0.5	0.5	NUM
admet-292	580	49	m	m	PROPN
admet-292	580	50	hcl	hcl	PROPN
admet-292	580	51	.	.	PUNCT
admet-292	581	1	distilled	distil	VERB
admet-292	581	2	water	water	NOUN
admet-292	581	3	has	have	VERB
admet-292	581	4	the	the	DET
admet-292	581	5	buffer	buffer	NOUN
admet-292	581	6	capacity	capacity	NOUN
admet-292	581	7	<	<	X
admet-292	581	8	0.005	0.005	NUM
admet-292	581	9	mm	mm	NOUN
admet-292	581	10	/	/	SYM
admet-292	581	11	ph	ph	NOUN
admet-292	581	12	.	.	PROPN
admet-292	582	1	so	so	ADV
admet-292	582	2	,	,	PUNCT
admet-292	582	3	to	to	PART
admet-292	582	4	change	change	VERB
admet-292	582	5	the	the	DET
admet-292	582	6	ph	ph	NOUN
admet-292	582	7	of	of	ADP
admet-292	582	8	distilled	distil	VERB
admet-292	582	9	water	water	NOUN
admet-292	582	10	from	from	ADP
admet-292	582	11	6.8	6.8	NUM
admet-292	582	12	to	to	PART
admet-292	582	13	6.7	6.7	NUM
admet-292	582	14	would	would	AUX
admet-292	582	15	require	require	VERB
admet-292	582	16	<	<	X
admet-292	582	17	0.001	0.001	NUM
admet-292	582	18	μl	μl	NUM
admet-292	582	19	of	of	ADP
admet-292	582	20	0.5	0.5	NUM
admet-292	582	21	m	m	PROPN
admet-292	582	22	hcl	hcl	PROPN
admet-292	582	23	.	.	PUNCT
admet-292	583	1	the	the	DET
admet-292	583	2	minimum	minimum	ADJ
admet-292	583	3	volume	volume	NOUN
admet-292	583	4	addition	addition	NOUN
admet-292	583	5	from	from	ADP
admet-292	583	6	dispensers	dispenser	NOUN
admet-292	583	7	in	in	ADP
admet-292	583	8	commercial	commercial	ADJ
admet-292	583	9	pka	pka	PROPN
admet-292	583	10	analyzers	analyzer	NOUN
admet-292	583	11	would	would	AUX
admet-292	583	12	produce	produce	VERB
admet-292	583	13	at	at	ADP
admet-292	583	14	least	least	ADJ
admet-292	583	15	a	a	DET
admet-292	583	16	ph	ph	ADJ
admet-292	583	17	2.1	2.1	NUM
admet-292	583	18	jump	jump	NOUN
admet-292	583	19	in	in	ADP
admet-292	583	20	the	the	DET
admet-292	583	21	ph	ph	ADJ
admet-292	583	22	5.8	5.8	NUM
admet-292	583	23	-	-	SYM
admet-292	583	24	8.4	8.4	NUM
admet-292	583	25	interval	interval	NOUN
admet-292	583	26	in	in	ADP
admet-292	583	27	distilled	distil	VERB
admet-292	583	28	water	water	NOUN
admet-292	583	29	.	.	PUNCT
admet-292	584	1	a	a	DET
admet-292	584	2	surprising	surprising	ADJ
admet-292	584	3	number	number	NOUN
admet-292	584	4	of	of	ADP
admet-292	584	5	investigators	investigator	NOUN
admet-292	584	6	prepare	prepare	VERB
admet-292	584	7	a	a	DET
admet-292	584	8	standard	standard	ADJ
admet-292	584	9	buffer	buffer	NOUN
admet-292	584	10	solution	solution	NOUN
admet-292	584	11	of	of	ADP
admet-292	584	12	a	a	DET
admet-292	584	13	known	know	VERB
admet-292	584	14	ph	ph	NOUN
admet-292	584	15	,	,	PUNCT
admet-292	584	16	but	but	CCONJ
admet-292	584	17	then	then	ADV
admet-292	584	18	neglect	neglect	NOUN
admet-292	584	19	to	to	PART
admet-292	584	20	measure	measure	VERB
admet-292	584	21	the	the	DET
admet-292	584	22	actual	actual	ADJ
admet-292	584	23	ph	ph	NOUN
admet-292	584	24	of	of	ADP
admet-292	584	25	the	the	DET
admet-292	584	26	drug	drug	NOUN
admet-292	584	27	-	-	PUNCT
admet-292	584	28	buffer	buffer	NOUN
admet-292	584	29	slurry	slurry	NOUN
admet-292	584	30	when	when	SCONJ
admet-292	584	31	equilibrium	equilibrium	NOUN
admet-292	584	32	is	be	AUX
admet-292	584	33	reached	reach	VERB
admet-292	584	34	.	.	PUNCT
admet-292	585	1	in	in	ADP
admet-292	585	2	common	common	ADJ
admet-292	585	3	practice	practice	NOUN
admet-292	585	4	,	,	PUNCT
admet-292	585	5	buffers	buffer	NOUN
admet-292	585	6	can	can	AUX
admet-292	585	7	be	be	AUX
admet-292	585	8	used	use	VERB
admet-292	585	9	to	to	PART
admet-292	585	10	set	set	VERB
admet-292	585	11	the	the	DET
admet-292	585	12	ph	ph	NOUN
admet-292	585	13	of	of	ADP
admet-292	585	14	an	an	DET
admet-292	585	15	assay	assay	NOUN
admet-292	585	16	solution	solution	NOUN
admet-292	585	17	to	to	ADP
admet-292	585	18	a	a	DET
admet-292	585	19	desired	desire	VERB
admet-292	585	20	value	value	NOUN
admet-292	585	21	.	.	PUNCT
admet-292	586	1	the	the	DET
admet-292	586	2	ph	ph	ADJ
admet-292	586	3	change	change	NOUN
admet-292	586	4	due	due	ADP
admet-292	586	5	to	to	ADP
admet-292	586	6	the	the	DET
admet-292	586	7	introduction	introduction	NOUN
admet-292	586	8	of	of	ADP
admet-292	586	9	drug	drug	NOUN
admet-292	586	10	is	be	AUX
admet-292	586	11	not	not	PART
admet-292	586	12	zero	zero	NUM
admet-292	586	13	,	,	PUNCT
admet-292	586	14	however	however	ADV
admet-292	586	15	.	.	PUNCT
admet-292	587	1	it	it	PRON
admet-292	587	2	depends	depend	VERB
admet-292	587	3	on	on	ADP
admet-292	587	4	the	the	DET
admet-292	587	5	capacity	capacity	NOUN
admet-292	587	6	of	of	ADP
admet-292	587	7	the	the	DET
admet-292	587	8	buffer	buffer	NOUN
admet-292	587	9	solution	solution	NOUN
admet-292	587	10	and	and	CCONJ
admet-292	587	11	the	the	DET
admet-292	587	12	ionization	ionization	NOUN
admet-292	587	13	characteristics	characteristic	NOUN
admet-292	587	14	and	and	CCONJ
admet-292	587	15	amount	amount	NOUN
admet-292	587	16	and	and	CCONJ
admet-292	587	17	solubility	solubility	NOUN
admet-292	587	18	of	of	ADP
admet-292	587	19	the	the	DET
admet-292	587	20	added	add	VERB
admet-292	587	21	drug	drug	NOUN
admet-292	587	22	.	.	PUNCT
admet-292	588	1	even	even	ADV
admet-292	588	2	with	with	ADP
admet-292	588	3	a	a	DET
admet-292	588	4	buffer	buffer	NOUN
admet-292	588	5	solution	solution	NOUN
admet-292	588	6	,	,	PUNCT
admet-292	588	7	the	the	DET
admet-292	588	8	ph	ph	NOUN
admet-292	588	9	can	can	AUX
admet-292	588	10	change	change	VERB
admet-292	588	11	by	by	ADP
admet-292	588	12	several	several	ADJ
admet-292	588	13	units	unit	NOUN
admet-292	588	14	upon	upon	SCONJ
admet-292	588	15	the	the	DET
admet-292	588	16	addition	addition	NOUN
admet-292	588	17	of	of	ADP
admet-292	588	18	an	an	DET
admet-292	588	19	ionizable	ionizable	ADJ
admet-292	588	20	substance	substance	NOUN
admet-292	588	21	.	.	PUNCT
admet-292	589	1	see	see	VERB
admet-292	589	2	table	table	NOUN
admet-292	589	3	1	1	NUM
admet-292	589	4	for	for	ADP
admet-292	589	5	examples	example	NOUN
admet-292	589	6	.	.	PUNCT
admet-292	590	1	adjusting	adjust	VERB
admet-292	590	2	ph	ph	NOUN
admet-292	590	3	in	in	ADP
admet-292	590	4	multi	multi	ADJ
admet-292	590	5	-	-	ADJ
admet-292	590	6	ph	ph	ADJ
admet-292	590	7	solubility	solubility	NOUN
admet-292	590	8	measurement	measurement	NOUN
admet-292	590	9	using	use	VERB
admet-292	590	10	a	a	DET
admet-292	590	11	titrant	titrant	NOUN
admet-292	590	12	there	there	PRON
admet-292	590	13	are	be	VERB
admet-292	590	14	many	many	ADJ
admet-292	590	15	different	different	ADJ
admet-292	590	16	ways	way	NOUN
admet-292	590	17	to	to	PART
admet-292	590	18	prepare	prepare	VERB
admet-292	590	19	multiple	multiple	ADJ
admet-292	590	20	-	-	PUNCT
admet-292	590	21	ph	ph	ADJ
admet-292	590	22	solutions	solution	NOUN
admet-292	590	23	in	in	ADP
admet-292	590	24	solubility	solubility	NOUN
admet-292	590	25	applications	application	NOUN
admet-292	590	26	.	.	PUNCT
admet-292	591	1	the	the	DET
admet-292	591	2	ph	ph	NOUN
admet-292	591	3	of	of	ADP
admet-292	591	4	the	the	DET
admet-292	591	5	solubility	solubility	NOUN
admet-292	591	6	medium	medium	NOUN
admet-292	591	7	can	can	AUX
admet-292	591	8	be	be	AUX
admet-292	591	9	modified	modify	VERB
admet-292	591	10	using	use	VERB
admet-292	591	11	a	a	DET
admet-292	591	12	standardized	standardized	ADJ
admet-292	591	13	titrant	titrant	NOUN
admet-292	591	14	,	,	PUNCT
admet-292	591	15	which	which	PRON
admet-292	591	16	can	can	AUX
admet-292	591	17	be	be	AUX
admet-292	591	18	a	a	DET
admet-292	591	19	strong	strong	ADJ
admet-292	591	20	electrolyte	electrolyte	NOUN
admet-292	591	21	,	,	PUNCT
admet-292	591	22	hcl	hcl	PROPN
admet-292	591	23	/	/	SYM
admet-292	591	24	naoh	naoh	NOUN
admet-292	591	25	,	,	PUNCT
admet-292	591	26	ch3so3h	ch3so3h	ADP
admet-292	591	27	,	,	PUNCT
admet-292	591	28	cf3cooh	cf3cooh	PROPN
admet-292	591	29	,	,	PUNCT
admet-292	591	30	or	or	CCONJ
admet-292	591	31	a	a	DET
admet-292	591	32	moderate	moderate	ADJ
admet-292	591	33	electrolyte	electrolyte	NOUN
admet-292	591	34	,	,	PUNCT
admet-292	591	35	like	like	ADP
admet-292	591	36	ch3cooh	ch3cooh	NOUN
admet-292	591	37	,	,	PUNCT
admet-292	591	38	h3po4	h3po4	NOUN
admet-292	591	39	,	,	PUNCT
admet-292	591	40	tartaric	tartaric	ADJ
admet-292	591	41	acid	acid	NOUN
admet-292	591	42	,	,	PUNCT
admet-292	591	43	l	l	NOUN
admet-292	591	44	-	-	NOUN
admet-292	591	45	lysine	lysine	NOUN
admet-292	591	46	,	,	PUNCT
admet-292	591	47	etc	etc	X
admet-292	591	48	.	.	X
admet-292	592	1	even	even	ADV
admet-292	592	2	though	though	SCONJ
admet-292	592	3	a	a	DET
admet-292	592	4	buffer	buffer	NOUN
admet-292	592	5	of	of	ADP
admet-292	592	6	a	a	DET
admet-292	592	7	known	know	VERB
admet-292	592	8	ph	ph	NOUN
admet-292	592	9	is	be	AUX
admet-292	592	10	used	use	VERB
admet-292	592	11	,	,	PUNCT
admet-292	592	12	let	let	VERB
admet-292	592	13	’s	’s	PRON
admet-292	592	14	accept	accept	VERB
admet-292	592	15	that	that	SCONJ
admet-292	592	16	the	the	DET
admet-292	592	17	final	final	ADJ
admet-292	592	18	ph	ph	NOUN
admet-292	592	19	of	of	ADP
admet-292	592	20	a	a	DET
admet-292	592	21	fully	fully	ADV
admet-292	592	22	-	-	PUNCT
admet-292	592	23	equilibrated	equilibrate	VERB
admet-292	592	24	drug	drug	NOUN
admet-292	592	25	-	-	PUNCT
admet-292	592	26	saturated	saturate	VERB
admet-292	592	27	solution	solution	NOUN
admet-292	592	28	has	have	VERB
admet-292	592	29	to	to	ADP
admet-292	592	30	recommendations	recommendation	NOUN
admet-292	592	31	for	for	ADP
admet-292	592	32	ph	ph	ADJ
admet-292	592	33	electrode	electrode	NOUN
admet-292	592	34	calibration	calibration	NOUN
admet-292	592	35	it	it	PRON
admet-292	592	36	is	be	AUX
admet-292	592	37	recommended	recommend	VERB
admet-292	592	38	that	that	SCONJ
admet-292	592	39	research	research	NOUN
admet-292	592	40	-	-	PUNCT
admet-292	592	41	grade	grade	NOUN
admet-292	592	42	combination	combination	NOUN
admet-292	592	43	ph	ph	NOUN
admet-292	592	44	glass	glass	NOUN
admet-292	592	45	electrodes	electrode	NOUN
admet-292	592	46	be	be	AUX
admet-292	592	47	used	use	VERB
admet-292	592	48	.	.	PUNCT
admet-292	593	1	it	it	PRON
admet-292	593	2	is	be	AUX
admet-292	593	3	a	a	DET
admet-292	593	4	good	good	ADJ
admet-292	593	5	idea	idea	NOUN
admet-292	593	6	to	to	PART
admet-292	593	7	identify	identify	VERB
admet-292	593	8	the	the	DET
admet-292	593	9	brand	brand	NOUN
admet-292	593	10	and	and	CCONJ
admet-292	593	11	make	make	NOUN
admet-292	593	12	of	of	ADP
admet-292	593	13	the	the	DET
admet-292	593	14	electrode	electrode	NOUN
admet-292	593	15	.	.	PUNCT
admet-292	594	1	the	the	DET
admet-292	594	2	calibration	calibration	NOUN
admet-292	594	3	procedure	procedure	NOUN
admet-292	594	4	used	use	VERB
admet-292	594	5	needs	need	NOUN
admet-292	594	6	to	to	PART
admet-292	594	7	be	be	AUX
admet-292	594	8	concisely	concisely	ADV
admet-292	594	9	described	describe	VERB
admet-292	594	10	.	.	PUNCT
admet-292	595	1	ideally	ideally	ADV
admet-292	595	2	,	,	PUNCT
admet-292	595	3	the	the	DET
admet-292	595	4	four	four	NUM
admet-292	595	5	-	-	PUNCT
admet-292	595	6	parameter	parameter	NOUN
admet-292	595	7	electrode	electrode	NOUN
admet-292	595	8	standardization	standardization	NOUN
admet-292	595	9	procedure	procedure	NOUN
admet-292	595	10	is	be	AUX
admet-292	595	11	recommended	recommend	VERB
admet-292	595	12	[	[	PUNCT
admet-292	595	13	45	45	NUM
admet-292	595	14	]	]	PUNCT
admet-292	595	15	.	.	PUNCT
admet-292	596	1	simpler	simple	ADJ
admet-292	596	2	procedures	procedure	NOUN
admet-292	596	3	may	may	AUX
admet-292	596	4	be	be	AUX
admet-292	596	5	satisfactory	satisfactory	ADJ
admet-292	596	6	,	,	PUNCT
admet-292	596	7	as	as	ADV
admet-292	596	8	long	long	ADV
admet-292	596	9	as	as	SCONJ
admet-292	596	10	they	they	PRON
admet-292	596	11	are	be	AUX
admet-292	596	12	described	describe	VERB
admet-292	596	13	precisely	precisely	ADV
admet-292	596	14	.	.	PUNCT
admet-292	597	1	the	the	DET
admet-292	597	2	reported	report	VERB
admet-292	597	3	ph	ph	NOUN
admet-292	597	4	should	should	AUX
admet-292	597	5	be	be	AUX
admet-292	597	6	on	on	ADP
admet-292	597	7	the	the	DET
admet-292	597	8	“	"	PUNCT
admet-292	597	9	operational	operational	ADJ
admet-292	597	10	”	"	PUNCT
admet-292	597	11	ph	ph	ADJ
admet-292	597	12	scale	scale	NOUN
admet-292	597	13	.	.	PUNCT
admet-292	598	1	the	the	DET
admet-292	598	2	standardization	standardization	NOUN
admet-292	598	3	procedure	procedure	NOUN
admet-292	598	4	can	can	AUX
admet-292	598	5	be	be	AUX
admet-292	598	6	used	use	VERB
admet-292	598	7	to	to	PART
admet-292	598	8	convert	convert	VERB
admet-292	598	9	ph	ph	NOUN
admet-292	598	10	to	to	ADP
admet-292	598	11	the	the	DET
admet-292	598	12	“	"	PUNCT
admet-292	598	13	concentration	concentration	NOUN
admet-292	598	14	”	"	PUNCT
admet-292	598	15	scale	scale	NOUN
admet-292	598	16	,	,	PUNCT
admet-292	598	17	pch	pch	PROPN
admet-292	598	18	,	,	PUNCT
admet-292	598	19	which	which	PRON
admet-292	598	20	is	be	AUX
admet-292	598	21	used	use	VERB
admet-292	598	22	in	in	ADP
admet-292	598	23	equilibrium	equilibrium	NOUN
admet-292	598	24	quotients	quotient	NOUN
admet-292	598	25	,	,	PUNCT
admet-292	598	26	as	as	SCONJ
admet-292	598	27	described	describe	VERB
admet-292	598	28	in	in	ADP
admet-292	598	29	appendix	appendix	ADJ
admet-292	598	30	c.	c.	PROPN
admet-292	598	31	particular	particular	ADJ
admet-292	598	32	attention	attention	NOUN
admet-292	598	33	should	should	AUX
admet-292	598	34	be	be	AUX
admet-292	598	35	given	give	VERB
admet-292	598	36	to	to	ADP
admet-292	598	37	the	the	DET
admet-292	598	38	ph	ph	ADJ
admet-292	598	39	electrode	electrode	NOUN
admet-292	598	40	calibration	calibration	NOUN
admet-292	598	41	when	when	SCONJ
admet-292	598	42	extreme	extreme	ADJ
admet-292	598	43	ph	ph	NOUN
admet-292	598	44	is	be	AUX
admet-292	598	45	measured	measure	VERB
admet-292	598	46	(	(	PUNCT
admet-292	598	47	ph<1	ph<1	PROPN
admet-292	598	48	or	or	CCONJ
admet-292	598	49	ph>12	ph>12	ADV
admet-292	598	50	)	)	PUNCT
admet-292	598	51	or	or	CCONJ
admet-292	598	52	when	when	SCONJ
admet-292	598	53	the	the	DET
admet-292	598	54	ionic	ionic	ADJ
admet-292	598	55	strength	strength	NOUN
admet-292	598	56	reaches	reach	VERB
admet-292	598	57	high	high	ADJ
admet-292	598	58	values	value	NOUN
admet-292	598	59	,	,	PUNCT
admet-292	598	60	as	as	ADP
admet-292	598	61	in	in	ADP
admet-292	598	62	the	the	DET
admet-292	598	63	case	case	NOUN
admet-292	598	64	of	of	ADP
admet-292	598	65	salt	salt	NOUN
admet-292	598	66	solubility	solubility	NOUN
admet-292	598	67	measurement	measurement	NOUN
admet-292	598	68	,	,	PUNCT
admet-292	598	69	or	or	CCONJ
admet-292	598	70	near	near	ADP
admet-292	598	71	zero	zero	NUM
admet-292	598	72	values	value	NOUN
admet-292	598	73	(	(	PUNCT
admet-292	598	74	in	in	ADP
admet-292	598	75	unbuffered	unbuffered	ADJ
admet-292	598	76	solutions	solution	NOUN
admet-292	598	77	)	)	PUNCT
admet-292	598	78	.	.	PUNCT
admet-292	599	1	admet	admet	PROPN
admet-292	599	2	&	&	CCONJ
admet-292	599	3	dmpk	dmpk	PROPN
admet-292	599	4	4(2	4(2	NUM
admet-292	599	5	)	)	PUNCT
admet-292	599	6	(	(	PUNCT
admet-292	599	7	2016	2016	NUM
admet-292	599	8	)	)	PUNCT
admet-292	599	9	117	117	NUM
admet-292	599	10	-	-	SYM
admet-292	599	11	178	178	NUM
admet-292	599	12	consensus	consensus	NOUN
admet-292	599	13	recommendations	recommendation	NOUN
admet-292	599	14	for	for	ADP
admet-292	599	15	improving	improve	VERB
admet-292	599	16	solubility	solubility	NOUN
admet-292	599	17	-	-	PUNCT
admet-292	599	18	ph	ph	ADJ
admet-292	599	19	data	datum	NOUN
admet-292	599	20	quality	quality	NOUN
admet-292	599	21	doi	doi	NOUN
admet-292	599	22	:	:	PUNCT
admet-292	599	23	10.5599	10.5599	NUM
admet-292	599	24	/	/	SYM
admet-292	599	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	599	26	147	147	NUM
admet-292	599	27	be	be	AUX
admet-292	599	28	actually	actually	ADV
admet-292	599	29	measured	measure	VERB
admet-292	599	30	.	.	PUNCT
admet-292	600	1	one	one	NUM
admet-292	600	2	way	way	NOUN
admet-292	600	3	(	(	PUNCT
admet-292	600	4	the	the	DET
admet-292	600	5	most	most	ADV
admet-292	600	6	popular	popular	ADJ
admet-292	600	7	)	)	PUNCT
admet-292	600	8	is	be	AUX
admet-292	600	9	to	to	PART
admet-292	600	10	look	look	VERB
admet-292	600	11	up	up	ADP
admet-292	600	12	standard	standard	ADJ
admet-292	600	13	buffer	buffer	NOUN
admet-292	600	14	recipes	recipe	NOUN
admet-292	600	15	and	and	CCONJ
admet-292	600	16	make	make	VERB
admet-292	600	17	the	the	DET
admet-292	600	18	buffers	buffer	NOUN
admet-292	600	19	to	to	ADP
admet-292	600	20	the	the	DET
admet-292	600	21	desired	desire	VERB
admet-292	600	22	ph	ph	NOUN
admet-292	600	23	.	.	PUNCT
admet-292	601	1	(	(	PUNCT
admet-292	601	2	many	many	ADJ
admet-292	601	3	of	of	ADP
admet-292	601	4	these	these	DET
admet-292	601	5	prepared	prepare	VERB
admet-292	601	6	buffer	buffer	NOUN
admet-292	601	7	solutions	solution	NOUN
admet-292	601	8	are	be	AUX
admet-292	601	9	commercially	commercially	ADV
admet-292	601	10	available	available	ADJ
admet-292	601	11	.	.	PUNCT
admet-292	601	12	)	)	PUNCT
admet-292	602	1	this	this	PRON
admet-292	602	2	may	may	AUX
admet-292	602	3	seem	seem	VERB
admet-292	602	4	like	like	ADP
admet-292	602	5	a	a	DET
admet-292	602	6	time	time	NOUN
admet-292	602	7	-	-	PUNCT
admet-292	602	8	saving	save	VERB
admet-292	602	9	approach	approach	NOUN
admet-292	602	10	,	,	PUNCT
admet-292	602	11	but	but	CCONJ
admet-292	602	12	the	the	DET
admet-292	602	13	choices	choice	NOUN
admet-292	602	14	of	of	ADP
admet-292	602	15	buffers	buffer	NOUN
admet-292	602	16	may	may	AUX
admet-292	602	17	be	be	AUX
admet-292	602	18	inappropriate	inappropriate	ADJ
admet-292	602	19	and	and	CCONJ
admet-292	602	20	may	may	AUX
admet-292	602	21	make	make	VERB
admet-292	602	22	the	the	DET
admet-292	602	23	analysis	analysis	NOUN
admet-292	602	24	of	of	ADP
admet-292	602	25	the	the	DET
admet-292	602	26	logs	log	NOUN
admet-292	602	27	-	-	PUNCT
admet-292	602	28	ph	ph	NOUN
admet-292	602	29	profile	profile	NOUN
admet-292	602	30	an	an	DET
admet-292	602	31	unnecessary	unnecessary	ADJ
admet-292	602	32	challenge	challenge	NOUN
admet-292	602	33	.	.	PUNCT
admet-292	603	1	if	if	SCONJ
admet-292	603	2	many	many	ADJ
admet-292	603	3	different	different	ADJ
admet-292	603	4	ingredients	ingredient	NOUN
admet-292	603	5	are	be	AUX
admet-292	603	6	selected	select	VERB
admet-292	603	7	to	to	PART
admet-292	603	8	cover	cover	VERB
admet-292	603	9	the	the	DET
admet-292	603	10	ph	ph	ADJ
admet-292	603	11	range	range	NOUN
admet-292	603	12	,	,	PUNCT
admet-292	603	13	instances	instance	NOUN
admet-292	603	14	of	of	ADP
admet-292	603	15	drugbuffer	drugbuffer	NOUN
admet-292	603	16	interactions	interaction	NOUN
admet-292	603	17	may	may	AUX
admet-292	603	18	be	be	AUX
admet-292	603	19	problematic	problematic	ADJ
admet-292	603	20	(	(	PUNCT
admet-292	603	21	figure	figure	NOUN
admet-292	603	22	2a	2a	NUM
admet-292	603	23	,	,	PUNCT
admet-292	603	24	[	[	X
admet-292	603	25	53	53	NUM
admet-292	603	26	]	]	PUNCT
admet-292	603	27	)	)	PUNCT
admet-292	603	28	.	.	PUNCT
admet-292	604	1	choosing	choose	VERB
admet-292	604	2	concentrated	concentrated	ADJ
admet-292	604	3	buffer	buffer	NOUN
admet-292	604	4	solutions	solution	NOUN
admet-292	604	5	can	can	AUX
admet-292	604	6	lead	lead	VERB
admet-292	604	7	to	to	ADP
admet-292	604	8	greater	great	ADJ
admet-292	604	9	drug	drug	NOUN
admet-292	604	10	-	-	PUNCT
admet-292	604	11	buffer	buffer	NOUN
admet-292	604	12	interactions	interaction	NOUN
admet-292	604	13	and	and	CCONJ
admet-292	604	14	excessively	excessively	ADV
admet-292	604	15	elevated	elevated	ADJ
admet-292	604	16	ionic	ionic	ADJ
admet-292	604	17	strengths	strength	NOUN
admet-292	604	18	in	in	ADP
admet-292	604	19	the	the	DET
admet-292	604	20	final	final	ADJ
admet-292	604	21	solutions	solution	NOUN
admet-292	604	22	.	.	PUNCT
admet-292	605	1	drug	drug	NOUN
admet-292	605	2	-	-	PUNCT
admet-292	605	3	buffer	buffer	NOUN
admet-292	605	4	complexes	complex	NOUN
admet-292	605	5	raise	raise	VERB
admet-292	605	6	solubility	solubility	NOUN
admet-292	605	7	,	,	PUNCT
admet-292	605	8	while	while	SCONJ
admet-292	605	9	drug	drug	NOUN
admet-292	605	10	-	-	PUNCT
admet-292	605	11	buffer	buffer	NOUN
admet-292	605	12	precipitates	precipitate	NOUN
admet-292	605	13	decrease	decrease	VERB
admet-292	605	14	solubility	solubility	NOUN
admet-292	605	15	.	.	PUNCT
admet-292	606	1	some	some	DET
admet-292	606	2	buffers	buffer	NOUN
admet-292	606	3	,	,	PUNCT
admet-292	606	4	such	such	ADJ
admet-292	606	5	as	as	ADP
admet-292	606	6	phosphate	phosphate	NOUN
admet-292	606	7	are	be	AUX
admet-292	606	8	not	not	PART
admet-292	606	9	compatible	compatible	ADJ
admet-292	606	10	with	with	ADP
admet-292	606	11	mass	mass	ADJ
admet-292	606	12	spectrometry	spectrometry	NOUN
admet-292	606	13	[	[	X
admet-292	606	14	53	53	NUM
admet-292	606	15	]	]	PUNCT
admet-292	606	16	.	.	PUNCT
admet-292	607	1	some	some	DET
admet-292	607	2	buffers	buffer	NOUN
admet-292	607	3	have	have	VERB
admet-292	607	4	too	too	ADV
admet-292	607	5	high	high	ADJ
admet-292	607	6	a	a	DET
admet-292	607	7	uv	uv	NOUN
admet-292	607	8	absorbance	absorbance	NOUN
admet-292	607	9	.	.	PUNCT
admet-292	608	1	boric	boric	ADJ
admet-292	608	2	acid	acid	NOUN
admet-292	608	3	buffers	buffer	NOUN
admet-292	608	4	can	can	AUX
admet-292	608	5	covalently	covalently	ADV
admet-292	608	6	interact	interact	VERB
admet-292	608	7	with	with	ADP
admet-292	608	8	1,2	1,2	NUM
admet-292	608	9	-	-	PUNCT
admet-292	608	10	diol	diol	NOUN
admet-292	608	11	portions	portion	NOUN
admet-292	608	12	in	in	ADP
admet-292	608	13	drug	drug	NOUN
admet-292	608	14	molecules	molecule	NOUN
admet-292	608	15	.	.	PUNCT
admet-292	609	1	some	some	DET
admet-292	609	2	combinations	combination	NOUN
admet-292	609	3	of	of	ADP
admet-292	609	4	buffers	buffer	NOUN
admet-292	609	5	have	have	AUX
admet-292	609	6	cross	cros	VERB
admet-292	609	7	interactions	interaction	NOUN
admet-292	609	8	:	:	PUNCT
admet-292	609	9	e.g.	e.g.	ADV
admet-292	609	10	,	,	PUNCT
admet-292	609	11	phosphate	phosphate	ADJ
admet-292	609	12	and	and	CCONJ
admet-292	609	13	ethylenediamine	ethylenediamine	NOUN
admet-292	609	14	buffers	buffer	NOUN
admet-292	609	15	can	can	AUX
admet-292	609	16	form	form	VERB
admet-292	609	17	ion	ion	NOUN
admet-292	609	18	-	-	PUNCT
admet-292	609	19	pairs	pair	NOUN
admet-292	609	20	[	[	PUNCT
admet-292	609	21	45	45	NUM
admet-292	609	22	]	]	PUNCT
admet-292	609	23	.	.	PUNCT
admet-292	610	1	the	the	DET
admet-292	610	2	optimal	optimal	ADJ
admet-292	610	3	choice	choice	NOUN
admet-292	610	4	of	of	ADP
admet-292	610	5	buffers	buffer	NOUN
admet-292	610	6	requires	require	VERB
admet-292	610	7	some	some	DET
admet-292	610	8	experience	experience	NOUN
admet-292	610	9	.	.	PUNCT
admet-292	611	1	another	another	DET
admet-292	611	2	way	way	NOUN
admet-292	611	3	(	(	PUNCT
admet-292	611	4	less	less	ADV
admet-292	611	5	popular	popular	ADJ
admet-292	611	6	)	)	PUNCT
admet-292	611	7	is	be	AUX
admet-292	611	8	to	to	PART
admet-292	611	9	avoid	avoid	VERB
admet-292	611	10	buffers	buffer	NOUN
admet-292	611	11	altogether	altogether	ADV
admet-292	611	12	.	.	PUNCT
admet-292	612	1	after	after	ADV
admet-292	612	2	all	all	ADV
admet-292	612	3	,	,	PUNCT
admet-292	612	4	the	the	DET
admet-292	612	5	ionizable	ionizable	ADJ
admet-292	612	6	drug	drug	NOUN
admet-292	612	7	being	be	AUX
admet-292	612	8	studied	study	VERB
admet-292	612	9	can	can	AUX
admet-292	612	10	act	act	VERB
admet-292	612	11	as	as	ADP
admet-292	612	12	its	its	PRON
admet-292	612	13	own	own	ADJ
admet-292	612	14	buffer	buffer	NOUN
admet-292	612	15	,	,	PUNCT
admet-292	612	16	particularly	particularly	ADV
admet-292	612	17	if	if	SCONJ
admet-292	612	18	the	the	DET
admet-292	612	19	drug	drug	NOUN
admet-292	612	20	molecule	molecule	NOUN
admet-292	612	21	has	have	VERB
admet-292	612	22	multiple	multiple	ADJ
admet-292	612	23	pka	pka	NOUN
admet-292	612	24	values	value	NOUN
admet-292	612	25	.	.	PUNCT
admet-292	613	1	so	so	ADV
admet-292	613	2	,	,	PUNCT
admet-292	613	3	self	self	NOUN
admet-292	613	4	-	-	PUNCT
admet-292	613	5	buffered	buffer	VERB
admet-292	613	6	solutions	solution	NOUN
admet-292	613	7	with	with	ADP
admet-292	613	8	excess	excess	ADJ
admet-292	613	9	solid	solid	NOUN
admet-292	613	10	can	can	AUX
admet-292	613	11	be	be	AUX
admet-292	613	12	adjusted	adjust	VERB
admet-292	613	13	to	to	ADP
admet-292	613	14	different	different	ADJ
admet-292	613	15	values	value	NOUN
admet-292	613	16	of	of	ADP
admet-292	613	17	ph	ph	NOUN
admet-292	613	18	by	by	ADP
admet-292	613	19	additions	addition	NOUN
admet-292	613	20	of	of	ADP
admet-292	613	21	hcl	hcl	PROPN
admet-292	613	22	or	or	CCONJ
admet-292	613	23	naoh	naoh	NOUN
admet-292	613	24	.	.	PUNCT
admet-292	614	1	this	this	PRON
admet-292	614	2	is	be	AUX
admet-292	614	3	actually	actually	ADV
admet-292	614	4	not	not	PART
admet-292	614	5	a	a	DET
admet-292	614	6	bad	bad	ADJ
admet-292	614	7	approach	approach	NOUN
admet-292	614	8	,	,	PUNCT
admet-292	614	9	since	since	SCONJ
admet-292	614	10	interferences	interference	NOUN
admet-292	614	11	due	due	ADP
admet-292	614	12	to	to	ADP
admet-292	614	13	drug	drug	NOUN
admet-292	614	14	-	-	PUNCT
admet-292	614	15	buffer	buffer	NOUN
admet-292	614	16	interactions	interaction	NOUN
admet-292	614	17	are	be	AUX
admet-292	614	18	eliminated	eliminate	VERB
admet-292	614	19	.	.	PUNCT
admet-292	615	1	the	the	DET
admet-292	615	2	downside	downside	NOUN
admet-292	615	3	of	of	ADP
admet-292	615	4	this	this	DET
admet-292	615	5	approach	approach	NOUN
admet-292	615	6	is	be	AUX
admet-292	615	7	that	that	SCONJ
admet-292	615	8	some	some	DET
admet-292	615	9	sparingly	sparingly	ADV
admet-292	615	10	soluble	soluble	ADJ
admet-292	615	11	drugs	drug	NOUN
admet-292	615	12	may	may	AUX
admet-292	615	13	have	have	VERB
admet-292	615	14	virtually	virtually	ADV
admet-292	615	15	no	no	DET
admet-292	615	16	buffer	buffer	NOUN
admet-292	615	17	capacity	capacity	NOUN
admet-292	615	18	over	over	ADP
admet-292	615	19	a	a	DET
admet-292	615	20	wide	wide	ADJ
admet-292	615	21	ph	ph	ADJ
admet-292	615	22	range	range	NOUN
admet-292	615	23	,	,	PUNCT
admet-292	615	24	so	so	SCONJ
admet-292	615	25	that	that	SCONJ
admet-292	615	26	impurities	impurity	NOUN
admet-292	615	27	may	may	AUX
admet-292	615	28	have	have	VERB
admet-292	615	29	an	an	DET
admet-292	615	30	inordinate	inordinate	ADJ
admet-292	615	31	sway	sway	NOUN
admet-292	615	32	over	over	ADP
admet-292	615	33	the	the	DET
admet-292	615	34	equilibrated	equilibrated	ADJ
admet-292	615	35	ph	ph	NOUN
admet-292	615	36	.	.	PROPN
admet-292	615	37	not	not	PART
admet-292	615	38	using	use	VERB
admet-292	615	39	auxiliary	auxiliary	ADJ
admet-292	615	40	buffers	buffer	NOUN
admet-292	615	41	would	would	AUX
admet-292	615	42	not	not	PART
admet-292	615	43	be	be	AUX
admet-292	615	44	recommended	recommend	VERB
admet-292	615	45	when	when	SCONJ
admet-292	615	46	studying	study	VERB
admet-292	615	47	practically	practically	ADV
admet-292	615	48	insoluble	insoluble	ADJ
admet-292	615	49	bases	basis	NOUN
admet-292	615	50	with	with	ADP
admet-292	615	51	pka	pka	PROPN
admet-292	615	52	>	>	X
admet-292	615	53	8	8	NUM
admet-292	615	54	(	(	PUNCT
admet-292	615	55	e.g.	e.g.	ADJ
admet-292	615	56	,	,	PUNCT
admet-292	615	57	terfenadine	terfenadine	NOUN
admet-292	615	58	,	,	PUNCT
admet-292	615	59	chlorpromazine	chlorpromazine	NOUN
admet-292	615	60	,	,	PUNCT
admet-292	615	61	etc	etc	X
admet-292	615	62	.	.	X
admet-292	615	63	)	)	PUNCT
admet-292	615	64	,	,	PUNCT
admet-292	615	65	since	since	SCONJ
admet-292	615	66	reading	read	VERB
admet-292	615	67	and	and	CCONJ
admet-292	615	68	adjusting	adjust	VERB
admet-292	615	69	ph	ph	NOUN
admet-292	615	70	may	may	AUX
admet-292	615	71	be	be	AUX
admet-292	615	72	problematic	problematic	ADJ
admet-292	615	73	experimentally	experimentally	ADV
admet-292	615	74	.	.	PUNCT
admet-292	616	1	the	the	DET
admet-292	616	2	third	third	ADJ
admet-292	616	3	way	way	NOUN
admet-292	616	4	(	(	PUNCT
admet-292	616	5	occasionally	occasionally	ADV
admet-292	616	6	used	use	VERB
admet-292	616	7	)	)	PUNCT
admet-292	616	8	is	be	AUX
admet-292	616	9	to	to	PART
admet-292	616	10	start	start	VERB
admet-292	616	11	with	with	ADP
admet-292	616	12	a	a	DET
admet-292	616	13	“	"	PUNCT
admet-292	616	14	universal	universal	ADJ
admet-292	616	15	”	"	PUNCT
admet-292	616	16	buffer	buffer	NOUN
admet-292	616	17	mixture	mixture	NOUN
admet-292	616	18	of	of	ADP
admet-292	616	19	several	several	ADJ
admet-292	616	20	individual	individual	ADJ
admet-292	616	21	buffer	buffer	NOUN
admet-292	616	22	components	component	NOUN
admet-292	616	23	.	.	PUNCT
admet-292	617	1	this	this	DET
admet-292	617	2	mixture	mixture	NOUN
admet-292	617	3	can	can	AUX
admet-292	617	4	be	be	AUX
admet-292	617	5	very	very	ADV
admet-292	617	6	beneficial	beneficial	ADJ
admet-292	617	7	,	,	PUNCT
admet-292	617	8	since	since	SCONJ
admet-292	617	9	the	the	DET
admet-292	617	10	buffer	buffer	NOUN
admet-292	617	11	capacity	capacity	NOUN
admet-292	617	12	remains	remain	VERB
admet-292	617	13	above	above	ADP
admet-292	617	14	a	a	DET
admet-292	617	15	certain	certain	ADJ
admet-292	617	16	minimum	minimum	ADJ
admet-292	617	17	level	level	NOUN
admet-292	617	18	across	across	ADP
admet-292	617	19	the	the	DET
admet-292	617	20	whole	whole	ADJ
admet-292	617	21	ph	ph	ADJ
admet-292	617	22	range	range	NOUN
admet-292	617	23	.	.	PUNCT
admet-292	618	1	for	for	ADP
admet-292	618	2	example	example	NOUN
admet-292	618	3	,	,	PUNCT
admet-292	618	4	the	the	DET
admet-292	618	5	britton	britton	PROPN
admet-292	618	6	-	-	PUNCT
admet-292	618	7	robinson	robinson	PROPN
admet-292	618	8	buffer	buffer	NOUN
admet-292	618	9	(	(	PUNCT
admet-292	618	10	acetic	acetic	ADJ
admet-292	618	11	acid	acid	NOUN
admet-292	618	12	,	,	PUNCT
admet-292	618	13	phosphoric	phosphoric	ADJ
admet-292	618	14	acid	acid	NOUN
admet-292	618	15	,	,	PUNCT
admet-292	618	16	boric	boric	ADJ
admet-292	618	17	acid	acid	NOUN
admet-292	618	18	,	,	PUNCT
admet-292	618	19	40	40	NUM
admet-292	618	20	mm	mm	NOUN
admet-292	618	21	each	each	PRON
admet-292	618	22	)	)	PUNCT
admet-292	618	23	has	have	VERB
admet-292	618	24	an	an	DET
admet-292	618	25	initial	initial	ADJ
admet-292	618	26	ph	ph	ADJ
admet-292	618	27	1.9	1.9	NUM
admet-292	618	28	[	[	X
admet-292	618	29	22	22	NUM
admet-292	618	30	]	]	PUNCT
admet-292	618	31	.	.	PUNCT
admet-292	619	1	it	it	PRON
admet-292	619	2	is	be	AUX
admet-292	619	3	quite	quite	ADV
admet-292	619	4	simple	simple	ADJ
admet-292	619	5	to	to	PART
admet-292	619	6	adjust	adjust	VERB
admet-292	619	7	the	the	DET
admet-292	619	8	ph	ph	NOUN
admet-292	619	9	to	to	ADP
admet-292	619	10	any	any	DET
admet-292	619	11	higher	high	ADJ
admet-292	619	12	value	value	NOUN
admet-292	619	13	,	,	PUNCT
admet-292	619	14	simply	simply	ADV
admet-292	619	15	by	by	ADP
admet-292	619	16	adding	add	VERB
admet-292	619	17	a	a	DET
admet-292	619	18	known	know	VERB
admet-292	619	19	amount	amount	NOUN
admet-292	619	20	of	of	ADP
admet-292	619	21	0.5	0.5	NUM
admet-292	619	22	m	m	PROPN
admet-292	619	23	naoh	naoh	NOUN
admet-292	619	24	(	(	PUNCT
admet-292	619	25	titrant	titrant	NOUN
admet-292	619	26	)	)	PUNCT
admet-292	619	27	.	.	PUNCT
admet-292	620	1	constancy	constancy	NOUN
admet-292	620	2	in	in	ADP
admet-292	620	3	ionic	ionic	ADJ
admet-292	620	4	strength	strength	NOUN
admet-292	620	5	across	across	ADP
admet-292	620	6	the	the	DET
admet-292	620	7	ph	ph	ADJ
admet-292	620	8	range	range	NOUN
admet-292	620	9	of	of	ADP
admet-292	620	10	interest	interest	NOUN
admet-292	620	11	is	be	AUX
admet-292	620	12	also	also	ADV
admet-292	620	13	desirable	desirable	ADJ
admet-292	620	14	,	,	PUNCT
admet-292	620	15	but	but	CCONJ
admet-292	620	16	most	most	ADJ
admet-292	620	17	universal	universal	ADJ
admet-292	620	18	buffer	buffer	NOUN
admet-292	620	19	formulations	formulation	NOUN
admet-292	620	20	fall	fall	VERB
admet-292	620	21	short	short	ADV
admet-292	620	22	of	of	ADP
admet-292	620	23	that	that	DET
admet-292	620	24	goal	goal	NOUN
admet-292	620	25	(	(	PUNCT
admet-292	620	26	cf	cf	NOUN
admet-292	620	27	.	.	NOUN
admet-292	620	28	,	,	PUNCT
admet-292	620	29	appendix	appendix	VERB
admet-292	620	30	a	a	PRON
admet-292	620	31	)	)	PUNCT
admet-292	620	32	.	.	PUNCT
admet-292	621	1	most	most	ADJ
admet-292	621	2	investigators	investigator	NOUN
admet-292	621	3	using	use	VERB
admet-292	621	4	universal	universal	ADJ
admet-292	621	5	buffers	buffer	NOUN
admet-292	621	6	pick	pick	VERB
admet-292	621	7	them	they	PRON
admet-292	621	8	from	from	ADP
admet-292	621	9	well	well	ADV
admet-292	621	10	-	-	PUNCT
admet-292	621	11	tested	test	VERB
admet-292	621	12	published	publish	VERB
admet-292	621	13	recipes	recipe	NOUN
admet-292	621	14	.	.	PUNCT
admet-292	622	1	(	(	PUNCT
admet-292	622	2	commercial	commercial	ADJ
admet-292	622	3	sources	source	NOUN
admet-292	622	4	of	of	ADP
admet-292	622	5	such	such	ADJ
admet-292	622	6	solutions	solution	NOUN
admet-292	622	7	are	be	AUX
admet-292	622	8	not	not	PART
admet-292	622	9	common	common	ADJ
admet-292	622	10	.	.	PUNCT
admet-292	622	11	)	)	PUNCT
admet-292	623	1	since	since	SCONJ
admet-292	623	2	the	the	DET
admet-292	623	3	universal	universal	ADJ
admet-292	623	4	buffers	buffer	NOUN
admet-292	623	5	were	be	AUX
admet-292	623	6	not	not	PART
admet-292	623	7	specifically	specifically	ADV
admet-292	623	8	designed	design	VERB
admet-292	623	9	for	for	ADP
admet-292	623	10	solubility	solubility	NOUN
admet-292	623	11	measurements	measurement	NOUN
admet-292	623	12	,	,	PUNCT
admet-292	623	13	their	their	PRON
admet-292	623	14	characteristics	characteristic	NOUN
admet-292	623	15	may	may	AUX
admet-292	623	16	not	not	PART
admet-292	623	17	be	be	AUX
admet-292	623	18	optimal	optimal	ADJ
admet-292	623	19	,	,	PUNCT
admet-292	623	20	for	for	ADP
admet-292	623	21	the	the	DET
admet-292	623	22	same	same	ADJ
admet-292	623	23	reasons	reason	NOUN
admet-292	623	24	as	as	SCONJ
admet-292	623	25	mentioned	mention	VERB
admet-292	623	26	above	above	ADV
admet-292	623	27	(	(	PUNCT
admet-292	623	28	drug	drug	NOUN
admet-292	623	29	-	-	PUNCT
admet-292	623	30	buffer	buffer	NOUN
admet-292	623	31	interactions	interaction	NOUN
admet-292	623	32	,	,	PUNCT
admet-292	623	33	excessive	excessive	ADJ
admet-292	623	34	ionic	ionic	ADJ
admet-292	623	35	strength	strength	NOUN
admet-292	623	36	,	,	PUNCT
admet-292	623	37	excessive	excessive	ADJ
admet-292	623	38	computational	computational	ADJ
admet-292	623	39	complexity	complexity	NOUN
admet-292	623	40	in	in	ADP
admet-292	623	41	data	datum	NOUN
admet-292	623	42	analysis	analysis	NOUN
admet-292	623	43	,	,	PUNCT
admet-292	623	44	etc	etc	X
admet-292	623	45	.	.	X
admet-292	623	46	)	)	PUNCT
admet-292	623	47	.	.	PUNCT
admet-292	624	1	the	the	DET
admet-292	624	2	fourth	fourth	ADJ
admet-292	624	3	way	way	NOUN
admet-292	624	4	(	(	PUNCT
admet-292	624	5	newly	newly	ADV
admet-292	624	6	explored	explore	VERB
admet-292	624	7	and	and	CCONJ
admet-292	624	8	quite	quite	ADV
admet-292	624	9	promising	promising	ADJ
admet-292	624	10	)	)	PUNCT
admet-292	624	11	is	be	AUX
admet-292	624	12	to	to	PART
admet-292	624	13	take	take	VERB
admet-292	624	14	the	the	DET
admet-292	624	15	best	good	ADJ
admet-292	624	16	of	of	ADP
admet-292	624	17	the	the	DET
admet-292	624	18	idea	idea	NOUN
admet-292	624	19	of	of	ADP
admet-292	624	20	universal	universal	ADJ
admet-292	624	21	buffers	buffer	NOUN
admet-292	624	22	,	,	PUNCT
admet-292	624	23	but	but	CCONJ
admet-292	624	24	reduce	reduce	VERB
admet-292	624	25	the	the	DET
admet-292	624	26	factors	factor	NOUN
admet-292	624	27	leading	lead	VERB
admet-292	624	28	to	to	ADP
admet-292	624	29	drug	drug	NOUN
admet-292	624	30	-	-	PUNCT
admet-292	624	31	buffer	buffer	NOUN
admet-292	624	32	complications	complication	NOUN
admet-292	624	33	noted	note	VERB
admet-292	624	34	above	above	ADV
admet-292	624	35	.	.	PUNCT
admet-292	625	1	such	such	ADJ
admet-292	625	2	new	new	ADJ
admet-292	625	3	buffers	buffer	NOUN
admet-292	625	4	may	may	AUX
admet-292	625	5	be	be	AUX
admet-292	625	6	called	call	VERB
admet-292	625	7	“	"	PUNCT
admet-292	625	8	minimalist	minimalist	ADJ
admet-292	625	9	universal	universal	ADJ
admet-292	625	10	buffers	buffer	NOUN
admet-292	625	11	”	"	PUNCT
admet-292	625	12	(	(	PUNCT
admet-292	625	13	mub	mub	NOUN
admet-292	625	14	)	)	PUNCT
admet-292	625	15	.	.	PUNCT
admet-292	626	1	minimalist	minimalist	ADJ
admet-292	626	2	universal	universal	ADJ
admet-292	626	3	buffer	buffer	NOUN
admet-292	626	4	(	(	PUNCT
admet-292	626	5	mub	mub	NOUN
admet-292	626	6	)	)	PUNCT
admet-292	626	7	formulation	formulation	NOUN
admet-292	626	8	traditionally	traditionally	ADV
admet-292	626	9	,	,	PUNCT
admet-292	626	10	universal	universal	ADJ
admet-292	626	11	buffer	buffer	NOUN
admet-292	626	12	design	design	NOUN
admet-292	626	13	required	require	VERB
admet-292	626	14	a	a	DET
admet-292	626	15	lot	lot	NOUN
admet-292	626	16	of	of	ADP
admet-292	626	17	experiments	experiment	NOUN
admet-292	626	18	to	to	PART
admet-292	626	19	be	be	AUX
admet-292	626	20	performed	perform	VERB
admet-292	626	21	to	to	PART
admet-292	626	22	come	come	VERB
admet-292	626	23	up	up	ADP
admet-292	626	24	with	with	ADP
admet-292	626	25	the	the	DET
admet-292	626	26	desired	desire	VERB
admet-292	626	27	formulation	formulation	NOUN
admet-292	626	28	.	.	PUNCT
admet-292	627	1	predicting	predict	VERB
admet-292	627	2	the	the	DET
admet-292	627	3	characteristics	characteristic	NOUN
admet-292	627	4	of	of	ADP
admet-292	627	5	universal	universal	ADJ
admet-292	627	6	buffers	buffer	NOUN
admet-292	627	7	computationally	computationally	ADV
admet-292	627	8	would	would	AUX
admet-292	627	9	have	have	AUX
admet-292	627	10	been	be	AUX
admet-292	627	11	quite	quite	DET
admet-292	627	12	a	a	DET
admet-292	627	13	challenge	challenge	NOUN
admet-292	627	14	then	then	ADV
admet-292	627	15	.	.	PUNCT
admet-292	628	1	now	now	ADV
admet-292	628	2	that	that	SCONJ
admet-292	628	3	such	such	ADJ
admet-292	628	4	computational	computational	ADJ
admet-292	628	5	approaches	approach	NOUN
admet-292	628	6	are	be	AUX
admet-292	628	7	possible	possible	ADJ
admet-292	628	8	,	,	PUNCT
admet-292	628	9	universal	universal	ADJ
admet-292	628	10	buffer	buffer	NOUN
admet-292	628	11	designs	design	NOUN
admet-292	628	12	specific	specific	ADJ
admet-292	628	13	to	to	ADP
admet-292	628	14	alex	alex	PROPN
admet-292	628	15	avdeef	avdeef	PROPN
admet-292	628	16	et	et	PROPN
admet-292	628	17	al	al	PROPN
admet-292	628	18	.	.	PROPN
admet-292	628	19	admet	admet	PROPN
admet-292	628	20	&	&	CCONJ
admet-292	628	21	dmpk	dmpk	PROPN
admet-292	628	22	4(2	4(2	NUM
admet-292	628	23	)	)	PUNCT
admet-292	628	24	(	(	PUNCT
admet-292	628	25	2016	2016	NUM
admet-292	628	26	)	)	PUNCT
admet-292	628	27	117	117	NUM
admet-292	628	28	-	-	SYM
admet-292	628	29	178	178	NUM
admet-292	628	30	148	148	NUM
admet-292	628	31	solubility	solubility	NOUN
admet-292	628	32	-	-	PUNCT
admet-292	628	33	ph	ph	NOUN
admet-292	628	34	applications	application	NOUN
admet-292	628	35	can	can	AUX
admet-292	628	36	be	be	AUX
admet-292	628	37	explored	explore	VERB
admet-292	628	38	easily	easily	ADV
admet-292	628	39	.	.	PUNCT
admet-292	629	1	in	in	ADP
admet-292	629	2	the	the	DET
admet-292	629	3	recent	recent	ADJ
admet-292	629	4	study	study	NOUN
admet-292	629	5	of	of	ADP
admet-292	629	6	the	the	DET
admet-292	629	7	solubility	solubility	NOUN
admet-292	629	8	-	-	PUNCT
admet-292	629	9	ph	ph	NOUN
admet-292	629	10	of	of	ADP
admet-292	629	11	terfenadine	terfenadine	NOUN
admet-292	629	12	,	,	PUNCT
admet-292	629	13	a	a	DET
admet-292	629	14	mub	mub	NOUN
admet-292	629	15	made	make	VERB
admet-292	629	16	of	of	ADP
admet-292	629	17	lactic	lactic	ADJ
admet-292	629	18	acid	acid	NOUN
admet-292	629	19	and	and	CCONJ
admet-292	629	20	ethylenediamine	ethylenediamine	NOUN
admet-292	629	21	was	be	AUX
admet-292	629	22	tested	test	VERB
admet-292	629	23	successfully	successfully	ADV
admet-292	629	24	[	[	X
admet-292	629	25	114	114	NUM
admet-292	629	26	]	]	PUNCT
admet-292	629	27	.	.	PUNCT
admet-292	630	1	in	in	ADP
admet-292	630	2	a	a	DET
admet-292	630	3	solubility	solubility	NOUN
admet-292	630	4	-	-	PUNCT
admet-292	630	5	ph	ph	NOUN
admet-292	630	6	assay	assay	NOUN
admet-292	630	7	,	,	PUNCT
admet-292	630	8	only	only	ADV
admet-292	630	9	the	the	DET
admet-292	630	10	regions	region	NOUN
admet-292	630	11	low	low	ADJ
admet-292	630	12	in	in	ADP
admet-292	630	13	buffer	buffer	NOUN
admet-292	630	14	capacity	capacity	NOUN
admet-292	630	15	need	need	VERB
admet-292	630	16	a	a	DET
admet-292	630	17	boost	boost	NOUN
admet-292	630	18	from	from	ADP
admet-292	630	19	an	an	DET
admet-292	630	20	auxiliary	auxiliary	ADJ
admet-292	630	21	buffer	buffer	NOUN
admet-292	630	22	.	.	PUNCT
admet-292	631	1	it	it	PRON
admet-292	631	2	can	can	AUX
admet-292	631	3	be	be	AUX
admet-292	631	4	computationally	computationally	ADV
admet-292	631	5	predicted	predict	VERB
admet-292	631	6	(	(	PUNCT
admet-292	631	7	e.g.	e.g.	ADV
admet-292	631	8	,	,	PUNCT
admet-292	631	9	pdisol	pdisol	ADJ
admet-292	631	10	-	-	PUNCT
admet-292	631	11	x	x	NOUN
admet-292	631	12	)	)	PUNCT
admet-292	631	13	what	what	PRON
admet-292	631	14	buffer	buffer	VERB
admet-292	631	15	capacity	capacity	NOUN
admet-292	631	16	the	the	DET
admet-292	631	17	drug	drug	NOUN
admet-292	631	18	itself	itself	PRON
admet-292	631	19	contributes	contribute	VERB
admet-292	631	20	to	to	ADP
admet-292	631	21	the	the	DET
admet-292	631	22	solution	solution	NOUN
admet-292	631	23	in	in	ADP
admet-292	631	24	the	the	DET
admet-292	631	25	ph	ph	ADJ
admet-292	631	26	range	range	NOUN
admet-292	631	27	of	of	ADP
admet-292	631	28	interest	interest	NOUN
admet-292	632	1	[	[	X
admet-292	632	2	22	22	NUM
admet-292	632	3	-	-	SYM
admet-292	632	4	25	25	NUM
admet-292	632	5	]	]	PUNCT
admet-292	632	6	.	.	PUNCT
admet-292	633	1	the	the	DET
admet-292	633	2	ph	ph	ADJ
admet-292	633	3	regions	region	NOUN
admet-292	633	4	of	of	ADP
admet-292	633	5	unacceptably	unacceptably	ADV
admet-292	633	6	low	low	ADJ
admet-292	633	7	buffer	buffer	NOUN
admet-292	633	8	capacity	capacity	NOUN
admet-292	633	9	can	can	AUX
admet-292	633	10	suggest	suggest	VERB
admet-292	633	11	which	which	DET
admet-292	633	12	auxiliary	auxiliary	ADJ
admet-292	633	13	buffer	buffer	NOUN
admet-292	633	14	to	to	PART
admet-292	633	15	use	use	VERB
admet-292	633	16	.	.	PUNCT
admet-292	634	1	without	without	ADP
admet-292	634	2	the	the	DET
admet-292	634	3	capacity	capacity	NOUN
admet-292	634	4	boost	boost	NOUN
admet-292	634	5	,	,	PUNCT
admet-292	634	6	it	it	PRON
admet-292	634	7	would	would	AUX
admet-292	634	8	be	be	AUX
admet-292	634	9	impractical	impractical	ADJ
admet-292	634	10	to	to	PART
admet-292	634	11	add	add	VERB
admet-292	634	12	the	the	DET
admet-292	634	13	extremely	extremely	ADV
admet-292	634	14	small	small	ADJ
admet-292	634	15	volumes	volume	NOUN
admet-292	634	16	of	of	ADP
admet-292	634	17	the	the	DET
admet-292	634	18	naoh	naoh	PROPN
admet-292	634	19	/	/	SYM
admet-292	634	20	hcl	hcl	PROPN
admet-292	634	21	titrant	titrant	NOUN
admet-292	634	22	to	to	PART
admet-292	634	23	adjust	adjust	VERB
admet-292	634	24	the	the	DET
admet-292	634	25	ph	ph	NOUN
admet-292	634	26	in	in	ADP
admet-292	634	27	0.2	0.2	NUM
admet-292	634	28	increments	increment	NOUN
admet-292	634	29	across	across	ADP
admet-292	634	30	the	the	DET
admet-292	634	31	low	low	ADJ
admet-292	634	32	-	-	PUNCT
admet-292	634	33	capacity	capacity	NOUN
admet-292	634	34	region	region	NOUN
admet-292	634	35	.	.	PUNCT
admet-292	635	1	in	in	ADP
admet-292	635	2	the	the	DET
admet-292	635	3	terfenadine	terfenadine	NOUN
admet-292	635	4	example	example	NOUN
admet-292	635	5	[	[	X
admet-292	635	6	114	114	NUM
admet-292	635	7	]	]	PUNCT
admet-292	635	8	,	,	PUNCT
admet-292	635	9	two	two	NUM
admet-292	635	10	such	such	ADJ
admet-292	635	11	regions	region	NOUN
admet-292	635	12	were	be	AUX
admet-292	635	13	identified	identify	VERB
admet-292	635	14	.	.	PUNCT
admet-292	636	1	a	a	DET
admet-292	636	2	mub	mub	NOUN
admet-292	636	3	consisting	consist	VERB
admet-292	636	4	of	of	ADP
admet-292	636	5	just	just	ADV
admet-292	636	6	two	two	NUM
admet-292	636	7	components	component	NOUN
admet-292	636	8	,	,	PUNCT
admet-292	636	9	10	10	NUM
admet-292	636	10	mm	mm	NOUN
admet-292	636	11	lactic	lactic	ADJ
admet-292	636	12	acid	acid	NOUN
admet-292	636	13	and	and	CCONJ
admet-292	636	14	10	10	NUM
admet-292	636	15	mm	mm	PROPN
admet-292	636	16	ethylenediamine	ethylenediamine	NOUN
admet-292	636	17	,	,	PUNCT
admet-292	636	18	filled	fill	VERB
admet-292	636	19	in	in	ADP
admet-292	636	20	the	the	DET
admet-292	636	21	buffer	buffer	NOUN
admet-292	636	22	capacity	capacity	NOUN
admet-292	636	23	holes	hole	NOUN
admet-292	636	24	.	.	PUNCT
admet-292	637	1	terfenadine	terfenadine	PROPN
admet-292	637	2	lactate	lactate	PROPN
admet-292	637	3	was	be	AUX
admet-292	637	4	not	not	PART
admet-292	637	5	expected	expect	VERB
admet-292	637	6	to	to	PART
admet-292	637	7	precipitate	precipitate	VERB
admet-292	637	8	,	,	PUNCT
admet-292	637	9	since	since	SCONJ
admet-292	637	10	the	the	DET
admet-292	637	11	lactic	lactic	ADJ
admet-292	637	12	acid	acid	NOUN
admet-292	637	13	concentration	concentration	NOUN
admet-292	637	14	was	be	AUX
admet-292	637	15	low	low	ADJ
admet-292	637	16	enough	enough	ADV
admet-292	637	17	.	.	PUNCT
admet-292	638	1	hcl	hcl	PROPN
admet-292	638	2	was	be	AUX
admet-292	638	3	used	use	VERB
admet-292	638	4	to	to	PART
admet-292	638	5	lower	lower	VERB
admet-292	638	6	the	the	DET
admet-292	638	7	ph	ph	NOUN
admet-292	638	8	to	to	ADP
admet-292	638	9	2	2	NUM
admet-292	638	10	,	,	PUNCT
admet-292	638	11	and	and	CCONJ
admet-292	638	12	the	the	DET
admet-292	638	13	chloride	chloride	NOUN
admet-292	638	14	salt	salt	NOUN
admet-292	638	15	of	of	ADP
admet-292	638	16	terfenadine	terfenadine	NOUN
admet-292	638	17	was	be	AUX
admet-292	638	18	characterized	characterize	VERB
admet-292	638	19	in	in	ADP
admet-292	638	20	the	the	DET
admet-292	638	21	ph	ph	ADJ
admet-292	638	22	2	2	NUM
admet-292	638	23	-	-	SYM
admet-292	638	24	5	5	NUM
admet-292	638	25	region	region	NOUN
admet-292	638	26	.	.	PUNCT
admet-292	639	1	the	the	DET
admet-292	639	2	ionic	ionic	ADJ
admet-292	639	3	strength	strength	NOUN
admet-292	639	4	was	be	AUX
admet-292	639	5	kept	keep	VERB
admet-292	639	6	well	well	ADV
admet-292	639	7	under	under	ADP
admet-292	639	8	control	control	NOUN
admet-292	639	9	.	.	PUNCT
admet-292	640	1	figure	figure	NOUN
admet-292	640	2	a3	a3	NOUN
admet-292	640	3	in	in	ADP
admet-292	640	4	appendix	appendix	NOUN
admet-292	640	5	a	a	DET
admet-292	640	6	shows	show	NOUN
admet-292	640	7	the	the	DET
admet-292	640	8	region	region	NOUN
admet-292	640	9	above	above	ADP
admet-292	640	10	ph	ph	PROPN
admet-292	640	11	5	5	NUM
admet-292	640	12	for	for	ADP
admet-292	640	13	haloperidol	haloperidol	NOUN
admet-292	640	14	where	where	SCONJ
admet-292	640	15	ethylenediamine	ethylenediamine	PROPN
admet-292	640	16	was	be	AUX
admet-292	640	17	a	a	DET
admet-292	640	18	useful	useful	ADJ
admet-292	640	19	added	add	VERB
admet-292	640	20	buffer	buffer	NOUN
admet-292	640	21	.	.	PUNCT
admet-292	641	1	there	there	ADV
admet-292	641	2	,	,	PUNCT
admet-292	641	3	the	the	DET
admet-292	641	4	steepness	steepness	NOUN
admet-292	641	5	in	in	ADP
admet-292	641	6	the	the	DET
admet-292	641	7	titration	titration	NOUN
admet-292	641	8	curve	curve	NOUN
admet-292	641	9	was	be	AUX
admet-292	641	10	lessened	lessen	VERB
admet-292	641	11	by	by	ADP
admet-292	641	12	the	the	DET
admet-292	641	13	added	add	VERB
admet-292	641	14	buffer	buffer	NOUN
admet-292	641	15	.	.	PUNCT
admet-292	642	1	for	for	ADP
admet-292	642	2	haloperidol	haloperidol	NOUN
admet-292	642	3	without	without	ADP
admet-292	642	4	such	such	DET
admet-292	642	5	a	a	DET
admet-292	642	6	capacity	capacity	NOUN
admet-292	642	7	boost	boost	NOUN
admet-292	642	8	,	,	PUNCT
admet-292	642	9	the	the	DET
admet-292	642	10	reading	reading	NOUN
admet-292	642	11	of	of	ADP
admet-292	642	12	ph	ph	PROPN
admet-292	642	13	>	>	X
admet-292	642	14	5	5	NUM
admet-292	642	15	would	would	AUX
admet-292	642	16	have	have	AUX
admet-292	642	17	been	be	AUX
admet-292	642	18	a	a	DET
admet-292	642	19	challenge	challenge	NOUN
admet-292	642	20	due	due	ADP
admet-292	642	21	to	to	ADP
admet-292	642	22	low	low	ADJ
admet-292	642	23	ionic	ionic	ADJ
admet-292	642	24	strength	strength	NOUN
admet-292	642	25	and	and	CCONJ
admet-292	642	26	the	the	DET
admet-292	642	27	concomitant	concomitant	ADJ
admet-292	642	28	junction	junction	NOUN
admet-292	642	29	potential	potential	ADJ
admet-292	642	30	effects	effect	NOUN
admet-292	642	31	.	.	PUNCT
admet-292	643	1	also	also	ADV
admet-292	643	2	,	,	PUNCT
admet-292	643	3	adjusting	adjust	VERB
admet-292	643	4	ph	ph	NOUN
admet-292	643	5	in	in	ADP
admet-292	643	6	increments	increment	NOUN
admet-292	643	7	of	of	ADP
admet-292	643	8	0.2	0.2	NUM
admet-292	643	9	in	in	ADP
admet-292	643	10	that	that	DET
admet-292	643	11	region	region	NOUN
admet-292	643	12	would	would	AUX
admet-292	643	13	not	not	PART
admet-292	643	14	have	have	AUX
admet-292	643	15	been	be	AUX
admet-292	643	16	feasible	feasible	ADJ
admet-292	643	17	with	with	ADP
admet-292	643	18	typical	typical	ADJ
admet-292	643	19	dispensers	dispenser	NOUN
admet-292	643	20	and	and	CCONJ
admet-292	643	21	titrant	titrant	NOUN
admet-292	643	22	concentrations	concentration	NOUN
admet-292	643	23	.	.	PUNCT
admet-292	644	1	ionization	ionization	NOUN
admet-292	644	2	constant	constant	ADJ
admet-292	644	3	(	(	PUNCT
admet-292	644	4	pka	pka	NOUN
admet-292	644	5	)	)	PUNCT
admet-292	644	6	high	high	ADJ
admet-292	644	7	-	-	PUNCT
admet-292	644	8	quality	quality	NOUN
admet-292	644	9	logs	log	NOUN
admet-292	644	10	-	-	PUNCT
admet-292	644	11	ph	ph	ADJ
admet-292	644	12	data	datum	NOUN
admet-292	644	13	are	be	AUX
admet-292	644	14	measured	measure	VERB
admet-292	644	15	so	so	SCONJ
admet-292	644	16	that	that	SCONJ
admet-292	644	17	a	a	DET
admet-292	644	18	reliable	reliable	ADJ
admet-292	644	19	value	value	NOUN
admet-292	644	20	of	of	ADP
admet-292	644	21	the	the	DET
admet-292	644	22	intrinsic	intrinsic	ADJ
admet-292	644	23	solubility	solubility	NOUN
admet-292	644	24	,	,	PUNCT
admet-292	644	25	s0	s0	PROPN
admet-292	644	26	,	,	PUNCT
admet-292	644	27	as	as	ADV
admet-292	644	28	well	well	ADV
admet-292	644	29	as	as	ADP
admet-292	644	30	of	of	ADP
admet-292	644	31	equilibrium	equilibrium	NOUN
admet-292	644	32	constants	constant	NOUN
admet-292	644	33	of	of	ADP
admet-292	644	34	any	any	DET
admet-292	644	35	self	self	NOUN
admet-292	644	36	-	-	PUNCT
admet-292	644	37	aggregates	aggregate	NOUN
admet-292	644	38	,	,	PUNCT
admet-292	644	39	micelles	micelle	NOUN
admet-292	644	40	,	,	PUNCT
admet-292	644	41	drug	drug	NOUN
admet-292	644	42	-	-	PUNCT
admet-292	644	43	buffer	buffer	NOUN
admet-292	644	44	complexes	complex	NOUN
admet-292	644	45	,	,	PUNCT
admet-292	644	46	and	and	CCONJ
admet-292	644	47	of	of	ADP
admet-292	644	48	the	the	DET
admet-292	644	49	salt	salt	NOUN
admet-292	644	50	or	or	CCONJ
admet-292	644	51	cocrystal	cocrystal	ADJ
admet-292	644	52	solubility	solubility	NOUN
admet-292	644	53	products	product	NOUN
admet-292	644	54	,	,	PUNCT
admet-292	644	55	ksp	ksp	PROPN
admet-292	644	56	,	,	PUNCT
admet-292	644	57	can	can	AUX
admet-292	644	58	be	be	AUX
admet-292	644	59	determined	determine	VERB
admet-292	644	60	.	.	PUNCT
admet-292	645	1	the	the	DET
admet-292	645	2	pka	pka	PROPN
admet-292	645	3	is	be	AUX
admet-292	645	4	required	require	VERB
admet-292	645	5	in	in	ADP
admet-292	645	6	the	the	DET
admet-292	645	7	calculations	calculation	NOUN
admet-292	645	8	.	.	PUNCT
admet-292	646	1	there	there	PRON
admet-292	646	2	were	be	VERB
admet-292	646	3	several	several	ADJ
admet-292	646	4	recommendations	recommendation	NOUN
admet-292	646	5	for	for	ADP
admet-292	646	6	buffer	buffer	NOUN
admet-292	646	7	use	use	VERB
admet-292	646	8	multiple	multiple	ADJ
admet-292	646	9	-	-	PUNCT
admet-292	646	10	ph	ph	ADJ
admet-292	646	11	assays	assay	NOUN
admet-292	646	12	using	use	VERB
admet-292	646	13	buffers	buffer	NOUN
admet-292	646	14	are	be	AUX
admet-292	646	15	recommended	recommend	VERB
admet-292	646	16	for	for	ADP
admet-292	646	17	general	general	ADJ
admet-292	646	18	applications	application	NOUN
admet-292	646	19	.	.	PUNCT
admet-292	647	1	in	in	ADP
admet-292	647	2	reporting	report	VERB
admet-292	647	3	solubility	solubility	NOUN
admet-292	647	4	-	-	PUNCT
admet-292	647	5	ph	ph	ADJ
admet-292	647	6	results	result	NOUN
admet-292	647	7	,	,	PUNCT
admet-292	647	8	state	state	NOUN
admet-292	647	9	precisely	precisely	ADV
admet-292	647	10	which	which	PRON
admet-292	647	11	buffers	buffer	NOUN
admet-292	647	12	were	be	AUX
admet-292	647	13	used	use	VERB
admet-292	647	14	:	:	PUNCT
admet-292	647	15	in	in	ADP
admet-292	647	16	which	which	PRON
admet-292	647	17	salt	salt	NOUN
admet-292	647	18	forms	form	NOUN
admet-292	647	19	and	and	CCONJ
admet-292	647	20	at	at	ADP
admet-292	647	21	what	what	DET
admet-292	647	22	concentrations	concentration	NOUN
admet-292	647	23	.	.	PUNCT
admet-292	648	1	this	this	PRON
admet-292	648	2	is	be	AUX
admet-292	648	3	needed	need	VERB
admet-292	648	4	information	information	NOUN
admet-292	648	5	for	for	ADP
admet-292	648	6	calculating	calculate	VERB
admet-292	648	7	the	the	DET
admet-292	648	8	total	total	ADJ
admet-292	648	9	ionic	ionic	ADJ
admet-292	648	10	strength	strength	NOUN
admet-292	648	11	at	at	ADP
admet-292	648	12	each	each	DET
admet-292	648	13	point	point	NOUN
admet-292	648	14	.	.	PUNCT
admet-292	649	1	note	note	VERB
admet-292	649	2	that	that	SCONJ
admet-292	649	3	the	the	DET
admet-292	649	4	use	use	NOUN
admet-292	649	5	of	of	ADP
admet-292	649	6	a	a	DET
admet-292	649	7	high	high	ADJ
admet-292	649	8	capacity	capacity	NOUN
admet-292	649	9	buffer	buffer	NOUN
admet-292	649	10	does	do	AUX
admet-292	649	11	not	not	PART
admet-292	649	12	eliminate	eliminate	VERB
admet-292	649	13	the	the	DET
admet-292	649	14	need	need	NOUN
admet-292	649	15	to	to	PART
admet-292	649	16	measure	measure	VERB
admet-292	649	17	the	the	DET
admet-292	649	18	equilibrium	equilibrium	NOUN
admet-292	649	19	ph	ph	NOUN
admet-292	649	20	of	of	ADP
admet-292	649	21	a	a	DET
admet-292	649	22	saturated	saturate	VERB
admet-292	649	23	solution	solution	NOUN
admet-292	649	24	.	.	PUNCT
admet-292	650	1	sufficient	sufficient	ADJ
admet-292	650	2	buffering	buffering	NOUN
admet-292	650	3	is	be	AUX
admet-292	650	4	needed	need	VERB
admet-292	650	5	so	so	SCONJ
admet-292	650	6	that	that	SCONJ
admet-292	650	7	ph	ph	NOUN
admet-292	650	8	can	can	AUX
admet-292	650	9	be	be	AUX
admet-292	650	10	measured	measure	VERB
admet-292	650	11	reliably	reliably	ADV
admet-292	650	12	and	and	CCONJ
admet-292	650	13	that	that	SCONJ
admet-292	650	14	the	the	DET
admet-292	650	15	titrant	titrant	NOUN
admet-292	650	16	can	can	AUX
admet-292	650	17	be	be	AUX
admet-292	650	18	dispensed	dispense	VERB
admet-292	650	19	precisely	precisely	ADV
admet-292	650	20	to	to	PART
admet-292	650	21	set	set	VERB
admet-292	650	22	the	the	DET
admet-292	650	23	desired	desire	VERB
admet-292	650	24	ph	ph	NOUN
admet-292	650	25	.	.	PROPN
admet-292	650	26	ordinarily	ordinarily	ADV
admet-292	650	27	,	,	PUNCT
admet-292	650	28	relatively	relatively	ADV
admet-292	650	29	low	low	ADJ
admet-292	650	30	buffer	buffer	NOUN
admet-292	650	31	concentrations	concentration	NOUN
admet-292	650	32	(	(	PUNCT
admet-292	650	33	e.g.	e.g.	ADV
admet-292	650	34	,	,	PUNCT
admet-292	650	35	5	5	NUM
admet-292	650	36	-	-	SYM
admet-292	650	37	25	25	NUM
admet-292	650	38	mm	mm	NOUN
admet-292	650	39	)	)	PUNCT
admet-292	650	40	can	can	AUX
admet-292	650	41	be	be	AUX
admet-292	650	42	recommended	recommend	VERB
admet-292	650	43	.	.	PUNCT
admet-292	651	1	use	use	NOUN
admet-292	651	2	of	of	ADP
admet-292	651	3	higher	high	ADJ
admet-292	651	4	concentrations	concentration	NOUN
admet-292	651	5	need	need	VERB
admet-292	651	6	to	to	PART
admet-292	651	7	be	be	AUX
admet-292	651	8	critically	critically	ADV
admet-292	651	9	justified	justify	VERB
admet-292	651	10	.	.	PUNCT
admet-292	652	1	the	the	DET
admet-292	652	2	sample	sample	NOUN
admet-292	652	3	itself	itself	PRON
admet-292	652	4	may	may	AUX
admet-292	652	5	be	be	AUX
admet-292	652	6	an	an	DET
admet-292	652	7	adequate	adequate	ADJ
admet-292	652	8	buffer	buffer	NOUN
admet-292	652	9	.	.	PUNCT
admet-292	653	1	it	it	PRON
admet-292	653	2	is	be	AUX
admet-292	653	3	not	not	PART
admet-292	653	4	beneficial	beneficial	ADJ
admet-292	653	5	to	to	PART
admet-292	653	6	overload	overload	VERB
admet-292	653	7	the	the	DET
admet-292	653	8	assay	assay	NOUN
admet-292	653	9	protocol	protocol	NOUN
admet-292	653	10	with	with	ADP
admet-292	653	11	added	add	VERB
admet-292	653	12	complications	complication	NOUN
admet-292	653	13	arising	arise	VERB
admet-292	653	14	from	from	ADP
admet-292	653	15	unintended	unintended	ADJ
admet-292	653	16	buffer	buffer	NOUN
admet-292	653	17	-	-	PUNCT
admet-292	653	18	drug	drug	NOUN
admet-292	653	19	interactions	interaction	NOUN
admet-292	653	20	.	.	PUNCT
admet-292	654	1	the	the	DET
admet-292	654	2	use	use	NOUN
admet-292	654	3	of	of	ADP
admet-292	654	4	universal	universal	ADJ
admet-292	654	5	buffers	buffer	NOUN
admet-292	654	6	(	(	PUNCT
admet-292	654	7	e.g.	e.g.	ADV
admet-292	654	8	,	,	PUNCT
admet-292	654	9	britton	britton	PROPN
admet-292	654	10	-	-	PUNCT
admet-292	654	11	robinson	robinson	PROPN
admet-292	654	12	,	,	PUNCT
admet-292	654	13	sorensen	sorensen	PROPN
admet-292	654	14	,	,	PUNCT
admet-292	654	15	mcilvaine	mcilvaine	ADJ
admet-292	654	16	–	–	PUNCT
admet-292	654	17	cf	cf	NOUN
admet-292	654	18	.	.	PUNCT
admet-292	654	19	,	,	PUNCT
admet-292	654	20	appendix	appendix	VERB
admet-292	654	21	a	a	PRON
admet-292	654	22	)	)	PUNCT
admet-292	654	23	can	can	AUX
admet-292	654	24	be	be	AUX
admet-292	654	25	very	very	ADV
admet-292	654	26	convenient	convenient	ADJ
admet-292	654	27	,	,	PUNCT
admet-292	654	28	but	but	CCONJ
admet-292	654	29	one	one	PRON
admet-292	654	30	must	must	AUX
admet-292	654	31	guard	guard	VERB
admet-292	654	32	against	against	ADP
admet-292	654	33	unintended	unintended	ADJ
admet-292	654	34	/	/	SYM
admet-292	654	35	unnecessary	unnecessary	ADJ
admet-292	654	36	complications	complication	NOUN
admet-292	654	37	.	.	PUNCT
admet-292	655	1	some	some	DET
admet-292	655	2	buffer	buffer	NOUN
admet-292	655	3	components	component	NOUN
admet-292	655	4	may	may	AUX
admet-292	655	5	cause	cause	VERB
admet-292	655	6	difficulties	difficulty	NOUN
admet-292	655	7	in	in	ADP
admet-292	655	8	uv	uv	NOUN
admet-292	655	9	or	or	CCONJ
admet-292	655	10	mass	mass	NOUN
admet-292	655	11	spectrometry	spectrometry	NOUN
admet-292	655	12	measurement	measurement	NOUN
admet-292	655	13	.	.	PUNCT
admet-292	656	1	the	the	DET
admet-292	656	2	mub	mub	NOUN
admet-292	656	3	approach	approach	NOUN
admet-292	656	4	merits	merit	VERB
admet-292	656	5	further	further	ADJ
admet-292	656	6	considerations	consideration	NOUN
admet-292	656	7	,	,	PUNCT
admet-292	656	8	since	since	SCONJ
admet-292	656	9	many	many	ADJ
admet-292	656	10	of	of	ADP
admet-292	656	11	the	the	DET
admet-292	656	12	down	down	NOUN
admet-292	656	13	-	-	PUNCT
admet-292	656	14	sides	side	NOUN
admet-292	656	15	of	of	ADP
admet-292	656	16	buffer	buffer	NOUN
admet-292	656	17	use	use	NOUN
admet-292	656	18	can	can	AUX
admet-292	656	19	be	be	AUX
admet-292	656	20	designed	design	VERB
admet-292	656	21	out	out	ADP
admet-292	656	22	.	.	PUNCT
admet-292	657	1	admet	admet	PROPN
admet-292	657	2	&	&	CCONJ
admet-292	657	3	dmpk	dmpk	PROPN
admet-292	657	4	4(2	4(2	NUM
admet-292	657	5	)	)	PUNCT
admet-292	657	6	(	(	PUNCT
admet-292	657	7	2016	2016	NUM
admet-292	657	8	)	)	PUNCT
admet-292	657	9	117	117	NUM
admet-292	657	10	-	-	SYM
admet-292	657	11	178	178	NUM
admet-292	657	12	consensus	consensus	NOUN
admet-292	657	13	recommendations	recommendation	NOUN
admet-292	657	14	for	for	ADP
admet-292	657	15	improving	improve	VERB
admet-292	657	16	solubility	solubility	NOUN
admet-292	657	17	-	-	PUNCT
admet-292	657	18	ph	ph	ADJ
admet-292	657	19	data	datum	NOUN
admet-292	657	20	quality	quality	NOUN
admet-292	657	21	doi	doi	NOUN
admet-292	657	22	:	:	PUNCT
admet-292	657	23	10.5599	10.5599	NUM
admet-292	657	24	/	/	SYM
admet-292	657	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	657	26	149	149	NUM
admet-292	657	27	examples	example	NOUN
admet-292	657	28	in	in	ADP
admet-292	657	29	the	the	DET
admet-292	657	30	case	case	NOUN
admet-292	657	31	studies	study	NOUN
admet-292	657	32	of	of	ADP
admet-292	657	33	how	how	SCONJ
admet-292	657	34	critical	critical	ADJ
admet-292	657	35	it	it	PRON
admet-292	657	36	can	can	AUX
admet-292	657	37	be	be	AUX
admet-292	657	38	to	to	PART
admet-292	657	39	know	know	VERB
admet-292	657	40	the	the	DET
admet-292	657	41	accurate	accurate	ADJ
admet-292	657	42	pka	pka	PROPN
admet-292	657	43	.	.	PUNCT
admet-292	658	1	the	the	DET
admet-292	658	2	temperature	temperature	NOUN
admet-292	658	3	associated	associate	VERB
admet-292	658	4	with	with	ADP
admet-292	658	5	the	the	DET
admet-292	658	6	pka	pka	PROPN
admet-292	658	7	needs	need	VERB
admet-292	658	8	to	to	PART
admet-292	658	9	match	match	VERB
admet-292	658	10	that	that	PRON
admet-292	658	11	of	of	ADP
admet-292	658	12	the	the	DET
admet-292	658	13	solubility	solubility	NOUN
admet-292	658	14	assay	assay	VERB
admet-292	658	15	.	.	PUNCT
admet-292	659	1	also	also	ADV
admet-292	659	2	,	,	PUNCT
admet-292	659	3	the	the	DET
admet-292	659	4	“	"	PUNCT
admet-292	659	5	reference	reference	NOUN
admet-292	659	6	”	"	PUNCT
admet-292	659	7	ionic	ionic	ADJ
admet-292	659	8	strength	strength	NOUN
admet-292	659	9	,	,	PUNCT
admet-292	659	10	iref	iref	NOUN
admet-292	659	11	,	,	PUNCT
admet-292	659	12	in	in	ADP
admet-292	659	13	data	data	NOUN
admet-292	659	14	analysis	analysis	NOUN
admet-292	659	15	needs	need	VERB
admet-292	659	16	to	to	PART
admet-292	659	17	be	be	AUX
admet-292	659	18	set	set	VERB
admet-292	659	19	equal	equal	ADJ
admet-292	659	20	to	to	ADP
admet-292	659	21	the	the	DET
admet-292	659	22	ionic	ionic	ADJ
admet-292	659	23	strength	strength	NOUN
admet-292	659	24	at	at	ADP
admet-292	659	25	which	which	PRON
admet-292	659	26	the	the	DET
admet-292	659	27	pka	pka	PROPN
admet-292	659	28	was	be	AUX
admet-292	659	29	determined	determine	VERB
admet-292	659	30	.	.	PUNCT
admet-292	660	1	in	in	ADP
admet-292	660	2	the	the	DET
admet-292	660	3	older	old	ADJ
admet-292	660	4	literature	literature	NOUN
admet-292	660	5	,	,	PUNCT
admet-292	660	6	sometimes	sometimes	ADV
admet-292	660	7	the	the	DET
admet-292	660	8	pka	pka	PROPN
admet-292	660	9	had	have	AUX
admet-292	660	10	been	be	AUX
admet-292	660	11	determined	determine	VERB
admet-292	660	12	from	from	ADP
admet-292	660	13	logs	log	NOUN
admet-292	660	14	-	-	PUNCT
admet-292	660	15	ph	ph	ADJ
admet-292	660	16	data	datum	NOUN
admet-292	660	17	[	[	X
admet-292	660	18	49	49	NUM
admet-292	660	19	,	,	PUNCT
admet-292	660	20	50	50	NUM
admet-292	660	21	]	]	PUNCT
admet-292	660	22	.	.	PUNCT
admet-292	661	1	the	the	DET
admet-292	661	2	required	require	VERB
admet-292	661	3	assumption	assumption	NOUN
admet-292	661	4	is	be	AUX
admet-292	661	5	that	that	SCONJ
admet-292	661	6	the	the	DET
admet-292	661	7	henderson	henderson	PROPN
admet-292	661	8	-	-	PUNCT
admet-292	661	9	hasselbalch	hasselbalch	PROPN
admet-292	661	10	accurately	accurately	ADV
admet-292	661	11	describes	describe	VERB
admet-292	661	12	the	the	DET
admet-292	661	13	logs	log	NOUN
admet-292	661	14	-	-	PUNCT
admet-292	661	15	ph	ph	NOUN
admet-292	661	16	curve	curve	NOUN
admet-292	661	17	.	.	PUNCT
admet-292	662	1	the	the	DET
admet-292	662	2	assumption	assumption	NOUN
admet-292	662	3	is	be	AUX
admet-292	662	4	not	not	PART
admet-292	662	5	valid	valid	ADJ
admet-292	662	6	in	in	ADP
admet-292	662	7	many	many	ADJ
admet-292	662	8	cases	case	NOUN
admet-292	662	9	,	,	PUNCT
admet-292	662	10	and	and	CCONJ
admet-292	662	11	thus	thus	ADV
admet-292	662	12	the	the	DET
admet-292	662	13	method	method	NOUN
admet-292	662	14	can	can	AUX
admet-292	662	15	result	result	VERB
admet-292	662	16	in	in	ADP
admet-292	662	17	large	large	ADJ
admet-292	662	18	systematic	systematic	ADJ
admet-292	662	19	errors	error	NOUN
admet-292	662	20	in	in	ADP
admet-292	662	21	the	the	DET
admet-292	662	22	pka	pka	PROPN
admet-292	662	23	value	value	NOUN
admet-292	662	24	(	(	PUNCT
admet-292	662	25	cf	cf	NOUN
admet-292	662	26	.	.	PUNCT
admet-292	662	27	,	,	PUNCT
admet-292	662	28	figure	figure	NOUN
admet-292	662	29	2c	2c	NUM
admet-292	662	30	)	)	PUNCT
admet-292	662	31	.	.	PUNCT
admet-292	663	1	it	it	PRON
admet-292	663	2	is	be	AUX
admet-292	663	3	far	far	ADV
admet-292	663	4	more	more	ADV
admet-292	663	5	reliable	reliable	ADJ
admet-292	663	6	to	to	PART
admet-292	663	7	use	use	VERB
admet-292	663	8	purpose	purpose	NOUN
admet-292	663	9	-	-	PUNCT
admet-292	663	10	designed	design	VERB
admet-292	663	11	pka	pka	PROPN
admet-292	663	12	measurement	measurement	NOUN
admet-292	663	13	techniques	technique	NOUN
admet-292	663	14	(	(	PUNCT
admet-292	663	15	e.g.	e.g.	ADV
admet-292	663	16	,	,	PUNCT
admet-292	663	17	potentiometric	potentiometric	ADJ
admet-292	663	18	,	,	PUNCT
admet-292	663	19	spectrophotometric	spectrophotometric	ADJ
admet-292	663	20	,	,	PUNCT
admet-292	663	21	or	or	CCONJ
admet-292	663	22	capillary	capillary	ADJ
admet-292	663	23	electrophoretic	electrophoretic	NOUN
admet-292	663	24	)	)	PUNCT
admet-292	663	25	,	,	PUNCT
admet-292	663	26	under	under	ADP
admet-292	663	27	conditions	condition	NOUN
admet-292	663	28	where	where	SCONJ
admet-292	663	29	ionic	ionic	ADJ
admet-292	663	30	strength	strength	NOUN
admet-292	663	31	is	be	AUX
admet-292	663	32	well	well	ADV
admet-292	663	33	controlled	control	VERB
admet-292	663	34	and	and	CCONJ
admet-292	663	35	complications	complication	NOUN
admet-292	663	36	due	due	ADP
admet-292	663	37	to	to	ADP
admet-292	663	38	sample	sample	NOUN
admet-292	663	39	complexation	complexation	NOUN
admet-292	663	40	,	,	PUNCT
admet-292	663	41	self	self	NOUN
admet-292	663	42	-	-	PUNCT
admet-292	663	43	aggregation	aggregation	NOUN
admet-292	663	44	,	,	PUNCT
admet-292	663	45	or	or	CCONJ
admet-292	663	46	precipitation	precipitation	NOUN
admet-292	663	47	are	be	AUX
admet-292	663	48	demonstrably	demonstrably	ADV
admet-292	663	49	avoided	avoid	VERB
admet-292	663	50	.	.	PUNCT
admet-292	664	1	it	it	PRON
admet-292	664	2	is	be	AUX
admet-292	664	3	felt	feel	VERB
admet-292	664	4	that	that	SCONJ
admet-292	664	5	commercially	commercially	ADV
admet-292	664	6	-	-	PUNCT
admet-292	664	7	available	available	ADJ
admet-292	664	8	pka	pka	PROPN
admet-292	664	9	prediction	prediction	NOUN
admet-292	664	10	programs	program	NOUN
admet-292	664	11	are	be	AUX
admet-292	664	12	not	not	PART
admet-292	664	13	accurate	accurate	ADJ
admet-292	664	14	enough	enough	ADV
admet-292	664	15	for	for	ADP
admet-292	664	16	use	use	NOUN
admet-292	664	17	in	in	ADP
admet-292	664	18	the	the	DET
admet-292	664	19	interpretation	interpretation	NOUN
admet-292	664	20	of	of	ADP
admet-292	664	21	experimental	experimental	ADJ
admet-292	664	22	logs	log	NOUN
admet-292	664	23	-	-	PUNCT
admet-292	664	24	ph	ph	ADJ
admet-292	664	25	data	datum	NOUN
admet-292	664	26	.	.	PUNCT
admet-292	665	1	it	it	PRON
admet-292	665	2	is	be	AUX
admet-292	665	3	quite	quite	ADV
admet-292	665	4	important	important	ADJ
admet-292	665	5	that	that	SCONJ
admet-292	665	6	when	when	SCONJ
admet-292	665	7	the	the	DET
admet-292	665	8	pka	pka	NOUN
admet-292	665	9	of	of	ADP
admet-292	665	10	a	a	DET
admet-292	665	11	sparingly	sparingly	ADV
admet-292	665	12	-	-	PUNCT
admet-292	665	13	soluble	soluble	ADJ
admet-292	665	14	drug	drug	NOUN
admet-292	665	15	is	be	AUX
admet-292	665	16	determined	determine	VERB
admet-292	665	17	at	at	ADP
admet-292	665	18	37	37	NUM
admet-292	665	19	°	°	ADP
admet-292	665	20	c	c	NOUN
admet-292	665	21	using	use	VERB
admet-292	665	22	the	the	DET
admet-292	665	23	cosolvent	cosolvent	ADJ
admet-292	665	24	extrapolation	extrapolation	NOUN
admet-292	665	25	method	method	NOUN
admet-292	665	26	,	,	PUNCT
admet-292	665	27	that	that	DET
admet-292	665	28	methanol	methanol	NOUN
admet-292	665	29	not	not	PART
admet-292	665	30	be	be	AUX
admet-292	665	31	used	use	VERB
admet-292	665	32	as	as	ADP
admet-292	665	33	the	the	DET
admet-292	665	34	organic	organic	ADJ
admet-292	665	35	solvent	solvent	NOUN
admet-292	665	36	.	.	PUNCT
admet-292	666	1	it	it	PRON
admet-292	666	2	is	be	AUX
admet-292	666	3	highly	highly	ADV
admet-292	666	4	volatile	volatile	ADJ
admet-292	666	5	,	,	PUNCT
admet-292	666	6	and	and	CCONJ
admet-292	666	7	systematic	systematic	ADJ
admet-292	666	8	errors	error	NOUN
admet-292	666	9	can	can	AUX
admet-292	666	10	confound	confound	VERB
admet-292	666	11	the	the	DET
admet-292	666	12	determination	determination	NOUN
admet-292	666	13	,	,	PUNCT
admet-292	666	14	which	which	PRON
admet-292	666	15	sometimes	sometimes	ADV
admet-292	666	16	can	can	AUX
admet-292	666	17	be	be	AUX
admet-292	666	18	difficult	difficult	ADJ
admet-292	666	19	to	to	PART
admet-292	666	20	recognize	recognize	VERB
admet-292	666	21	.	.	PUNCT
admet-292	667	1	a	a	DET
admet-292	667	2	suitable	suitable	ADJ
admet-292	667	3	solvent	solvent	ADJ
admet-292	667	4	alternative	alternative	NOUN
admet-292	667	5	is	be	AUX
admet-292	667	6	n	n	PRON
admet-292	667	7	-	-	PUNCT
admet-292	667	8	propanol	propanol	NOUN
admet-292	667	9	.	.	PUNCT
admet-292	668	1	however	however	ADV
admet-292	668	2	,	,	PUNCT
admet-292	668	3	if	if	SCONJ
admet-292	668	4	the	the	DET
admet-292	668	5	pka	pka	PROPN
admet-292	668	6	assay	assay	NOUN
admet-292	668	7	can	can	AUX
admet-292	668	8	be	be	AUX
admet-292	668	9	performed	perform	VERB
admet-292	668	10	rapidly	rapidly	ADV
admet-292	668	11	(	(	PUNCT
admet-292	668	12	<	<	X
admet-292	668	13	3	3	NUM
admet-292	668	14	-	-	SYM
admet-292	668	15	5	5	NUM
admet-292	668	16	min	min	NOUN
admet-292	668	17	)	)	PUNCT
admet-292	668	18	,	,	PUNCT
admet-292	668	19	the	the	DET
admet-292	668	20	amount	amount	NOUN
admet-292	668	21	of	of	ADP
admet-292	668	22	methanol	methanol	NOUN
admet-292	668	23	lost	lose	VERB
admet-292	668	24	may	may	AUX
admet-292	668	25	be	be	AUX
admet-292	668	26	small	small	ADJ
admet-292	668	27	at	at	ADP
admet-292	668	28	37	37	NUM
admet-292	668	29	°	°	NOUN
admet-292	668	30	c	c	NOUN
admet-292	668	31	.	.	PUNCT
admet-292	669	1	(	(	PUNCT
admet-292	669	2	when	when	SCONJ
admet-292	669	3	using	use	VERB
admet-292	669	4	methanol	methanol	NOUN
admet-292	669	5	-	-	PUNCT
admet-292	669	6	water	water	NOUN
admet-292	669	7	solutions	solution	NOUN
admet-292	669	8	,	,	PUNCT
admet-292	669	9	it	it	PRON
admet-292	669	10	could	could	AUX
admet-292	669	11	be	be	AUX
admet-292	669	12	prudent	prudent	ADJ
admet-292	669	13	to	to	PART
admet-292	669	14	measure	measure	VERB
admet-292	669	15	the	the	DET
admet-292	669	16	final	final	ADJ
admet-292	669	17	solution	solution	NOUN
admet-292	669	18	volume	volume	NOUN
admet-292	669	19	,	,	PUNCT
admet-292	669	20	e.g.	e.g.	ADV
admet-292	669	21	,	,	PUNCT
admet-292	669	22	by	by	ADP
admet-292	669	23	weighting	weight	VERB
admet-292	669	24	the	the	DET
admet-292	669	25	vial	vial	ADJ
admet-292	669	26	before	before	ADV
admet-292	669	27	and	and	CCONJ
admet-292	669	28	after	after	ADP
admet-292	669	29	the	the	DET
admet-292	669	30	assay	assay	NOUN
admet-292	669	31	.	.	PUNCT
admet-292	669	32	)	)	PUNCT
admet-292	670	1	equilibration	equilibration	NOUN
admet-292	670	2	time	time	NOUN
admet-292	670	3	and	and	CCONJ
admet-292	670	4	stirring	stirring	ADJ
admet-292	670	5	protocol	protocol	NOUN
admet-292	670	6	one	one	NUM
admet-292	670	7	of	of	ADP
admet-292	670	8	the	the	DET
admet-292	670	9	most	most	ADV
admet-292	670	10	important	important	ADJ
admet-292	670	11	experimental	experimental	ADJ
admet-292	670	12	conditions	condition	NOUN
admet-292	670	13	of	of	ADP
admet-292	670	14	determination	determination	NOUN
admet-292	670	15	of	of	ADP
admet-292	670	16	equilibrium	equilibrium	NOUN
admet-292	670	17	solubility	solubility	NOUN
admet-292	670	18	is	be	AUX
admet-292	670	19	that	that	SCONJ
admet-292	670	20	in	in	ADP
admet-292	670	21	the	the	DET
admet-292	670	22	solubility	solubility	NOUN
admet-292	670	23	suspension	suspension	NOUN
admet-292	670	24	,	,	PUNCT
admet-292	670	25	the	the	DET
admet-292	670	26	system	system	NOUN
admet-292	670	27	has	have	VERB
admet-292	670	28	to	to	PART
admet-292	670	29	achieve	achieve	VERB
admet-292	670	30	the	the	DET
admet-292	670	31	equilibrium	equilibrium	NOUN
admet-292	670	32	state	state	NOUN
admet-292	670	33	.	.	PUNCT
admet-292	671	1	that	that	PRON
admet-292	671	2	is	be	AUX
admet-292	671	3	,	,	PUNCT
admet-292	671	4	when	when	SCONJ
admet-292	671	5	the	the	DET
admet-292	671	6	dissolution	dissolution	ADJ
admet-292	671	7	rate	rate	NOUN
admet-292	671	8	of	of	ADP
admet-292	671	9	the	the	DET
admet-292	671	10	solid	solid	NOUN
admet-292	671	11	is	be	AUX
admet-292	671	12	equal	equal	ADJ
admet-292	671	13	to	to	ADP
admet-292	671	14	its	its	PRON
admet-292	671	15	precipitation	precipitation	NOUN
admet-292	671	16	rate	rate	NOUN
admet-292	671	17	from	from	ADP
admet-292	671	18	the	the	DET
admet-292	671	19	solution	solution	NOUN
admet-292	671	20	.	.	PUNCT
admet-292	672	1	this	this	DET
admet-292	672	2	dynamic	dynamic	ADJ
admet-292	672	3	equilibrium	equilibrium	NOUN
admet-292	672	4	can	can	AUX
admet-292	672	5	be	be	AUX
admet-292	672	6	maintained	maintain	VERB
admet-292	672	7	only	only	ADV
admet-292	672	8	by	by	ADP
admet-292	672	9	the	the	DET
admet-292	672	10	presence	presence	NOUN
admet-292	672	11	of	of	ADP
admet-292	672	12	solid	solid	ADJ
admet-292	672	13	in	in	ADP
admet-292	672	14	the	the	DET
admet-292	672	15	system	system	NOUN
admet-292	672	16	.	.	PUNCT
admet-292	673	1	perturbation	perturbation	NOUN
admet-292	673	2	,	,	PUNCT
admet-292	673	3	like	like	ADP
admet-292	673	4	filtration	filtration	NOUN
admet-292	673	5	can	can	AUX
admet-292	673	6	invalidate	invalidate	VERB
admet-292	673	7	this	this	DET
admet-292	673	8	condition	condition	NOUN
admet-292	673	9	.	.	PUNCT
admet-292	674	1	the	the	DET
admet-292	674	2	optimal	optimal	ADJ
admet-292	674	3	time	time	NOUN
admet-292	674	4	of	of	ADP
admet-292	674	5	equilibration	equilibration	NOUN
admet-292	674	6	(	(	PUNCT
admet-292	674	7	also	also	ADV
admet-292	674	8	called	call	VERB
admet-292	674	9	incubation	incubation	NOUN
admet-292	674	10	time	time	NOUN
admet-292	674	11	)	)	PUNCT
admet-292	674	12	in	in	ADP
admet-292	674	13	the	the	DET
admet-292	674	14	sf	sf	PROPN
admet-292	674	15	method	method	NOUN
admet-292	674	16	is	be	AUX
admet-292	674	17	difficult	difficult	ADJ
admet-292	674	18	to	to	PART
admet-292	674	19	specify	specify	VERB
admet-292	674	20	and	and	CCONJ
admet-292	674	21	is	be	AUX
admet-292	674	22	often	often	ADV
admet-292	674	23	a	a	DET
admet-292	674	24	debated	debate	VERB
admet-292	674	25	topic	topic	NOUN
admet-292	674	26	.	.	PUNCT
admet-292	675	1	the	the	DET
admet-292	675	2	equilibration	equilibration	NOUN
admet-292	675	3	time	time	NOUN
admet-292	675	4	is	be	AUX
admet-292	675	5	mainly	mainly	ADV
admet-292	675	6	determined	determine	VERB
admet-292	675	7	by	by	ADP
admet-292	675	8	the	the	DET
admet-292	675	9	dissolution	dissolution	NOUN
admet-292	675	10	rate	rate	NOUN
admet-292	675	11	of	of	ADP
admet-292	675	12	the	the	DET
admet-292	675	13	compound	compound	NOUN
admet-292	675	14	,	,	PUNCT
admet-292	675	15	which	which	PRON
admet-292	675	16	depends	depend	VERB
admet-292	675	17	on	on	ADP
admet-292	675	18	many	many	ADJ
admet-292	675	19	factors	factor	NOUN
admet-292	675	20	like	like	ADP
admet-292	675	21	morphology	morphology	NOUN
admet-292	675	22	,	,	PUNCT
admet-292	675	23	crystallinity	crystallinity	NOUN
admet-292	675	24	,	,	PUNCT
admet-292	675	25	and	and	CCONJ
admet-292	675	26	particle	particle	NOUN
admet-292	675	27	size	size	NOUN
admet-292	675	28	.	.	PUNCT
admet-292	676	1	the	the	DET
admet-292	676	2	fine	fine	ADJ
admet-292	676	3	micro	micro	NOUN
admet-292	676	4	-	-	NOUN
admet-292	676	5	crystals	crystal	NOUN
admet-292	676	6	dissolve	dissolve	VERB
admet-292	676	7	more	more	ADV
admet-292	676	8	quickly	quickly	ADV
admet-292	676	9	than	than	ADP
admet-292	676	10	large	large	ADJ
admet-292	676	11	ones	one	NOUN
admet-292	676	12	;	;	PUNCT
admet-292	676	13	amorphous	amorphous	ADJ
admet-292	676	14	solids	solid	NOUN
admet-292	676	15	dissolve	dissolve	VERB
admet-292	676	16	faster	fast	ADV
admet-292	676	17	than	than	ADP
admet-292	676	18	crystalline	crystalline	ADJ
admet-292	676	19	substances	substance	NOUN
admet-292	676	20	.	.	PUNCT
admet-292	677	1	the	the	DET
admet-292	677	2	optimal	optimal	ADJ
admet-292	677	3	time	time	NOUN
admet-292	677	4	valid	valid	ADJ
admet-292	677	5	for	for	ADP
admet-292	677	6	every	every	DET
admet-292	677	7	compound	compound	NOUN
admet-292	677	8	can	can	AUX
admet-292	677	9	not	not	PART
admet-292	677	10	be	be	AUX
admet-292	677	11	specified	specify	VERB
admet-292	677	12	.	.	PUNCT
admet-292	678	1	so	so	ADV
admet-292	678	2	the	the	DET
admet-292	678	3	best	good	ADJ
admet-292	678	4	practice	practice	NOUN
admet-292	678	5	in	in	ADP
admet-292	678	6	the	the	DET
admet-292	678	7	most	most	ADV
admet-292	678	8	rigorous	rigorous	ADJ
admet-292	678	9	application	application	NOUN
admet-292	678	10	of	of	ADP
admet-292	678	11	the	the	DET
admet-292	678	12	sf	sf	PROPN
admet-292	678	13	method	method	NOUN
admet-292	678	14	is	be	AUX
admet-292	678	15	to	to	PART
admet-292	678	16	check	check	VERB
admet-292	678	17	the	the	DET
admet-292	678	18	required	require	VERB
admet-292	678	19	incubation	incubation	NOUN
admet-292	678	20	time	time	NOUN
admet-292	678	21	from	from	ADP
admet-292	678	22	compound	compound	NOUN
admet-292	678	23	to	to	AUX
admet-292	678	24	compound	compound	VERB
admet-292	678	25	.	.	PUNCT
admet-292	679	1	however	however	ADV
admet-292	679	2	,	,	PUNCT
admet-292	679	3	in	in	ADP
admet-292	679	4	a	a	DET
admet-292	679	5	standard	standard	ADJ
admet-292	679	6	protocol	protocol	NOUN
admet-292	679	7	suggested	suggest	VERB
admet-292	679	8	for	for	ADP
admet-292	679	9	routine	routine	ADJ
admet-292	679	10	measurement	measurement	NOUN
admet-292	679	11	,	,	PUNCT
admet-292	679	12	a	a	DET
admet-292	679	13	generally	generally	ADV
admet-292	679	14	accepted	accept	VERB
admet-292	679	15	equilibration	equilibration	NOUN
admet-292	679	16	time	time	NOUN
admet-292	679	17	would	would	AUX
admet-292	679	18	be	be	AUX
admet-292	679	19	useful	useful	ADJ
admet-292	679	20	.	.	PUNCT
admet-292	680	1	in	in	ADP
admet-292	680	2	a	a	DET
admet-292	680	3	recommendations	recommendation	NOUN
admet-292	680	4	for	for	ADP
admet-292	680	5	pka	pka	NOUN
admet-292	680	6	determination	determination	NOUN
admet-292	680	7	the	the	DET
admet-292	680	8	determination	determination	NOUN
admet-292	680	9	of	of	ADP
admet-292	680	10	the	the	DET
admet-292	680	11	pka	pka	PROPN
admet-292	680	12	solely	solely	ADV
admet-292	680	13	from	from	ADP
admet-292	680	14	solubility	solubility	NOUN
admet-292	680	15	-	-	PUNCT
admet-292	680	16	ph	ph	NOUN
admet-292	680	17	data	datum	NOUN
admet-292	680	18	can	can	AUX
admet-292	680	19	not	not	PART
admet-292	680	20	be	be	AUX
admet-292	680	21	recommended	recommend	VERB
admet-292	680	22	.	.	PUNCT
admet-292	681	1	it	it	PRON
admet-292	681	2	is	be	AUX
admet-292	681	3	recommended	recommend	VERB
admet-292	681	4	that	that	SCONJ
admet-292	681	5	methods	method	NOUN
admet-292	681	6	specifically	specifically	ADV
admet-292	681	7	designed	design	VERB
admet-292	681	8	to	to	PART
admet-292	681	9	determine	determine	VERB
admet-292	681	10	pka	pka	PROPN
admet-292	681	11	of	of	ADP
admet-292	681	12	very	very	ADV
admet-292	681	13	poorly	poorly	ADV
admet-292	681	14	soluble	soluble	ADJ
admet-292	681	15	molecules	molecule	NOUN
admet-292	681	16	be	be	AUX
admet-292	681	17	used	use	VERB
admet-292	681	18	(	(	PUNCT
admet-292	681	19	e.g.	e.g.	ADV
admet-292	681	20	,	,	PUNCT
admet-292	681	21	state	state	NOUN
admet-292	681	22	-	-	PUNCT
admet-292	681	23	of	of	ADP
admet-292	681	24	-	-	PUNCT
admet-292	681	25	the	the	DET
admet-292	681	26	-	-	PUNCT
admet-292	681	27	art	art	NOUN
admet-292	681	28	uv	uv	NOUN
admet-292	681	29	spectrophotometry	spectrophotometry	NOUN
admet-292	681	30	,	,	PUNCT
admet-292	681	31	capillary	capillary	ADJ
admet-292	681	32	electrophoresis	electrophoresis	NOUN
admet-292	681	33	,	,	PUNCT
admet-292	681	34	potentiometry	potentiometry	NOUN
admet-292	681	35	)	)	PUNCT
admet-292	681	36	.	.	PUNCT
admet-292	682	1	these	these	DET
admet-292	682	2	methods	method	NOUN
admet-292	682	3	are	be	AUX
admet-292	682	4	widely	widely	ADV
admet-292	682	5	available	available	ADJ
admet-292	682	6	and	and	CCONJ
admet-292	682	7	have	have	AUX
admet-292	682	8	been	be	AUX
admet-292	682	9	fine	fine	ADV
admet-292	682	10	-	-	PUNCT
admet-292	682	11	tuned	tune	VERB
admet-292	682	12	for	for	ADP
admet-292	682	13	the	the	DET
admet-292	682	14	challenge	challenge	NOUN
admet-292	682	15	.	.	PUNCT
admet-292	683	1	commercial	commercial	ADJ
admet-292	683	2	pka	pka	PROPN
admet-292	683	3	instruments	instrument	NOUN
admet-292	683	4	based	base	VERB
admet-292	683	5	on	on	ADP
admet-292	683	6	the	the	DET
admet-292	683	7	above	above	ADJ
admet-292	683	8	three	three	NUM
admet-292	683	9	technologies	technology	NOUN
admet-292	683	10	are	be	AUX
admet-292	683	11	generally	generally	ADV
admet-292	683	12	well	well	ADV
admet-292	683	13	-	-	PUNCT
admet-292	683	14	supported	support	VERB
admet-292	683	15	by	by	ADP
admet-292	683	16	their	their	PRON
admet-292	683	17	manufacturers	manufacturer	NOUN
admet-292	683	18	.	.	PUNCT
admet-292	684	1	alex	alex	PROPN
admet-292	684	2	avdeef	avdeef	PROPN
admet-292	684	3	et	et	PROPN
admet-292	684	4	al	al	PROPN
admet-292	684	5	.	.	PROPN
admet-292	684	6	admet	admet	PROPN
admet-292	684	7	&	&	CCONJ
admet-292	684	8	dmpk	dmpk	PROPN
admet-292	684	9	4(2	4(2	NUM
admet-292	684	10	)	)	PUNCT
admet-292	684	11	(	(	PUNCT
admet-292	684	12	2016	2016	NUM
admet-292	684	13	)	)	PUNCT
admet-292	684	14	117	117	NUM
admet-292	684	15	-	-	SYM
admet-292	684	16	178	178	NUM
admet-292	684	17	150	150	NUM
admet-292	684	18	comprehensive	comprehensive	ADJ
admet-292	684	19	study	study	NOUN
admet-292	684	20	–	–	PUNCT
admet-292	684	21	among	among	ADP
admet-292	684	22	other	other	ADJ
admet-292	684	23	factors	factor	NOUN
admet-292	684	24	–	–	PUNCT
admet-292	684	25	the	the	DET
admet-292	684	26	effect	effect	NOUN
admet-292	684	27	of	of	ADP
admet-292	684	28	incubation	incubation	NOUN
admet-292	684	29	time	time	NOUN
admet-292	684	30	was	be	AUX
admet-292	684	31	tested	test	VERB
admet-292	684	32	on	on	ADP
admet-292	684	33	the	the	DET
admet-292	684	34	equilibrium	equilibrium	NOUN
admet-292	684	35	solubility	solubility	NOUN
admet-292	684	36	of	of	ADP
admet-292	684	37	model	model	NOUN
admet-292	684	38	compound	compound	NOUN
admet-292	684	39	,	,	PUNCT
admet-292	684	40	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-292	685	1	[	[	X
admet-292	685	2	3	3	NUM
admet-292	685	3	]	]	PUNCT
admet-292	685	4	.	.	PUNCT
admet-292	686	1	the	the	DET
admet-292	686	2	achievement	achievement	NOUN
admet-292	686	3	of	of	ADP
admet-292	686	4	equilibrium	equilibrium	NOUN
admet-292	686	5	was	be	AUX
admet-292	686	6	divided	divide	VERB
admet-292	686	7	into	into	ADP
admet-292	686	8	two	two	NUM
admet-292	686	9	different	different	ADJ
admet-292	686	10	steps	step	NOUN
admet-292	686	11	:	:	PUNCT
admet-292	686	12	vigorous	vigorous	ADJ
admet-292	686	13	agitation	agitation	NOUN
admet-292	686	14	of	of	ADP
admet-292	686	15	solubility	solubility	NOUN
admet-292	686	16	suspension	suspension	NOUN
admet-292	686	17	with	with	ADP
admet-292	686	18	stirring	stirring	NOUN
admet-292	686	19	and	and	CCONJ
admet-292	686	20	sedimentation	sedimentation	NOUN
admet-292	686	21	.	.	PUNCT
admet-292	687	1	first	first	ADV
admet-292	687	2	,	,	PUNCT
admet-292	687	3	the	the	DET
admet-292	687	4	time	time	NOUN
admet-292	687	5	of	of	ADP
admet-292	687	6	stirring	stirring	NOUN
admet-292	687	7	was	be	AUX
admet-292	687	8	varied	varied	ADJ
admet-292	687	9	between	between	ADP
admet-292	687	10	0.5	0.5	NUM
admet-292	687	11	and	and	CCONJ
admet-292	687	12	48	48	NUM
admet-292	687	13	h	h	NOUN
admet-292	687	14	,	,	PUNCT
admet-292	687	15	followed	follow	VERB
admet-292	687	16	by	by	ADP
admet-292	687	17	constant	constant	ADJ
admet-292	687	18	time	time	NOUN
admet-292	687	19	sedimentation	sedimentation	NOUN
admet-292	687	20	.	.	PUNCT
admet-292	688	1	second	second	ADJ
admet-292	688	2	,	,	PUNCT
admet-292	688	3	after	after	ADP
admet-292	688	4	48	48	NUM
admet-292	688	5	h	h	NOUN
admet-292	688	6	of	of	ADP
admet-292	688	7	constant	constant	ADJ
admet-292	688	8	stirring	stirring	NOUN
admet-292	688	9	time	time	NOUN
admet-292	688	10	,	,	PUNCT
admet-292	688	11	the	the	DET
admet-292	688	12	sedimentation	sedimentation	NOUN
admet-292	688	13	was	be	AUX
admet-292	688	14	varied	varied	ADJ
admet-292	688	15	between	between	ADP
admet-292	688	16	1	1	NUM
admet-292	688	17	and	and	CCONJ
admet-292	688	18	24h	24h	NOUN
admet-292	688	19	(	(	PUNCT
admet-292	688	20	figures	figure	NOUN
admet-292	688	21	2	2	NUM
admet-292	688	22	and	and	CCONJ
admet-292	688	23	3	3	NUM
admet-292	688	24	in	in	ADP
admet-292	688	25	[	[	X
admet-292	688	26	3	3	NUM
admet-292	688	27	]	]	NUM
admet-292	688	28	)	)	PUNCT
admet-292	688	29	.	.	PUNCT
admet-292	689	1	the	the	DET
admet-292	689	2	study	study	NOUN
admet-292	689	3	revealed	reveal	VERB
admet-292	689	4	that	that	SCONJ
admet-292	689	5	sedimentation	sedimentation	NOUN
admet-292	689	6	is	be	AUX
admet-292	689	7	an	an	DET
admet-292	689	8	indispensable	indispensable	ADJ
admet-292	689	9	part	part	NOUN
admet-292	689	10	of	of	ADP
admet-292	689	11	incubation	incubation	NOUN
admet-292	689	12	,	,	PUNCT
admet-292	689	13	because	because	SCONJ
admet-292	689	14	during	during	ADP
admet-292	689	15	the	the	DET
admet-292	689	16	intensive	intensive	ADJ
admet-292	689	17	stirring	stirring	NOUN
admet-292	689	18	,	,	PUNCT
admet-292	689	19	a	a	DET
admet-292	689	20	supersaturated	supersaturated	ADJ
admet-292	689	21	solution	solution	NOUN
admet-292	689	22	can	can	AUX
admet-292	689	23	form	form	VERB
admet-292	689	24	,	,	PUNCT
admet-292	689	25	which	which	PRON
admet-292	689	26	needs	need	VERB
admet-292	689	27	adequate	adequate	ADJ
admet-292	689	28	time	time	NOUN
admet-292	689	29	in	in	ADP
admet-292	689	30	a	a	DET
admet-292	689	31	resting	rest	VERB
admet-292	689	32	state	state	NOUN
admet-292	689	33	to	to	PART
admet-292	689	34	form	form	VERB
admet-292	689	35	the	the	DET
admet-292	689	36	true	true	ADJ
admet-292	689	37	equilibrium	equilibrium	NOUN
admet-292	689	38	.	.	PUNCT
admet-292	690	1	based	base	VERB
admet-292	690	2	on	on	ADP
admet-292	690	3	these	these	DET
admet-292	690	4	results	result	NOUN
admet-292	690	5	24	24	NUM
admet-292	690	6	h	h	NOUN
admet-292	690	7	incubation	incubation	NOUN
admet-292	690	8	time	time	NOUN
admet-292	690	9	(	(	PUNCT
admet-292	690	10	6	6	NUM
admet-292	690	11	h	h	NOUN
admet-292	690	12	stirring	stirring	NOUN
admet-292	690	13	followed	follow	VERB
admet-292	690	14	by	by	ADP
admet-292	690	15	18	18	NUM
admet-292	690	16	h	h	NOUN
admet-292	690	17	sedimentation	sedimentation	NOUN
admet-292	690	18	)	)	PUNCT
admet-292	690	19	was	be	AUX
admet-292	690	20	suggested	suggest	VERB
admet-292	690	21	as	as	ADP
admet-292	690	22	a	a	DET
admet-292	690	23	general	general	ADJ
admet-292	690	24	protocol	protocol	NOUN
admet-292	690	25	.	.	PUNCT
admet-292	691	1	it	it	PRON
admet-292	691	2	may	may	AUX
admet-292	691	3	be	be	AUX
admet-292	691	4	noted	note	VERB
admet-292	691	5	that	that	SCONJ
admet-292	691	6	practically	practically	ADV
admet-292	691	7	insoluble	insoluble	ADJ
admet-292	691	8	compounds	compound	NOUN
admet-292	691	9	which	which	PRON
admet-292	691	10	consequently	consequently	ADV
admet-292	691	11	have	have	VERB
admet-292	691	12	very	very	ADV
admet-292	691	13	slow	slow	ADJ
admet-292	691	14	dissolution	dissolution	NOUN
admet-292	691	15	rates	rate	NOUN
admet-292	691	16	may	may	AUX
admet-292	691	17	require	require	VERB
admet-292	691	18	much	much	ADV
admet-292	691	19	longer	long	ADJ
admet-292	691	20	dissolution	dissolution	ADJ
admet-292	691	21	time	time	NOUN
admet-292	691	22	.	.	PUNCT
admet-292	692	1	the	the	DET
admet-292	692	2	unusually	unusually	ADV
admet-292	692	3	high	high	ADJ
admet-292	692	4	standard	standard	ADJ
admet-292	692	5	deviation	deviation	NOUN
admet-292	692	6	of	of	ADP
admet-292	692	7	solubility	solubility	NOUN
admet-292	692	8	obtained	obtain	VERB
admet-292	692	9	by	by	ADP
admet-292	692	10	the	the	DET
admet-292	692	11	above	above	ADJ
admet-292	692	12	standard	standard	ADJ
admet-292	692	13	protocol	protocol	NOUN
admet-292	692	14	may	may	AUX
admet-292	692	15	be	be	AUX
admet-292	692	16	an	an	DET
admet-292	692	17	indicator	indicator	NOUN
admet-292	692	18	of	of	ADP
admet-292	692	19	the	the	DET
admet-292	692	20	problem	problem	NOUN
admet-292	692	21	.	.	PUNCT
admet-292	693	1	in	in	ADP
admet-292	693	2	such	such	ADJ
admet-292	693	3	case	case	NOUN
admet-292	693	4	,	,	PUNCT
admet-292	693	5	a	a	DET
admet-292	693	6	series	series	NOUN
admet-292	693	7	of	of	ADP
admet-292	693	8	repeated	repeat	VERB
admet-292	693	9	measurements	measurement	NOUN
admet-292	693	10	with	with	ADP
admet-292	693	11	increasing	increase	VERB
admet-292	693	12	agitation	agitation	NOUN
admet-292	693	13	time	time	NOUN
admet-292	693	14	would	would	AUX
admet-292	693	15	be	be	AUX
admet-292	693	16	necessary	necessary	ADJ
admet-292	693	17	until	until	SCONJ
admet-292	693	18	the	the	DET
admet-292	693	19	solubility	solubility	NOUN
admet-292	693	20	is	be	AUX
admet-292	693	21	no	no	ADV
admet-292	693	22	longer	long	ADV
admet-292	693	23	changing	change	VERB
admet-292	693	24	.	.	PUNCT
admet-292	694	1	some	some	PRON
admet-292	694	2	reported	report	VERB
admet-292	694	3	extremely	extremely	ADV
admet-292	694	4	long	long	ADJ
admet-292	694	5	equilibration	equilibration	NOUN
admet-292	694	6	time	time	NOUN
admet-292	694	7	(	(	PUNCT
admet-292	694	8	e.g.	e.g.	ADV
admet-292	694	9	,	,	PUNCT
admet-292	694	10	10	10	NUM
admet-292	694	11	-	-	SYM
admet-292	694	12	30	30	NUM
admet-292	694	13	d	d	NOUN
admet-292	694	14	)	)	PUNCT
admet-292	694	15	set	set	VERB
admet-292	694	16	up	up	ADP
admet-292	694	17	several	several	ADJ
admet-292	694	18	problems	problem	NOUN
admet-292	694	19	:	:	PUNCT
admet-292	694	20	decomposition	decomposition	NOUN
admet-292	694	21	of	of	ADP
admet-292	694	22	the	the	DET
admet-292	694	23	sample	sample	NOUN
admet-292	694	24	,	,	PUNCT
admet-292	694	25	molding	molding	NOUN
admet-292	694	26	of	of	ADP
admet-292	694	27	the	the	DET
admet-292	694	28	buffer	buffer	NOUN
admet-292	694	29	,	,	PUNCT
admet-292	694	30	changing	change	VERB
admet-292	694	31	the	the	DET
admet-292	694	32	ph	ph	ADJ
admet-292	694	33	,	,	PUNCT
admet-292	694	34	evaporation	evaporation	NOUN
admet-292	694	35	,	,	PUNCT
admet-292	694	36	difficulty	difficulty	NOUN
admet-292	694	37	in	in	ADP
admet-292	694	38	temperature	temperature	NOUN
admet-292	694	39	control	control	NOUN
admet-292	694	40	,	,	PUNCT
admet-292	694	41	etc	etc	X
admet-292	694	42	.	.	X
admet-292	694	43	methods	method	NOUN
admet-292	694	44	shortening	shorten	VERB
admet-292	694	45	the	the	DET
admet-292	694	46	incubation	incubation	NOUN
admet-292	694	47	time	time	NOUN
admet-292	694	48	are	be	AUX
admet-292	694	49	known	know	VERB
admet-292	694	50	but	but	CCONJ
admet-292	694	51	not	not	PART
admet-292	694	52	widely	widely	ADV
admet-292	694	53	used	use	VERB
admet-292	694	54	in	in	ADP
admet-292	694	55	the	the	DET
admet-292	694	56	practice	practice	NOUN
admet-292	694	57	[	[	X
admet-292	694	58	115	115	NUM
admet-292	694	59	]	]	PUNCT
admet-292	694	60	.	.	PUNCT
admet-292	695	1	separating	separate	VERB
admet-292	695	2	solid	solid	ADV
admet-292	695	3	from	from	ADP
admet-292	695	4	saturated	saturate	VERB
admet-292	695	5	solution	solution	NOUN
admet-292	695	6	three	three	NUM
admet-292	695	7	alternative	alternative	ADJ
admet-292	695	8	techniques	technique	NOUN
admet-292	695	9	(	(	PUNCT
admet-292	695	10	sedimentation	sedimentation	NOUN
admet-292	695	11	,	,	PUNCT
admet-292	695	12	centrifugation	centrifugation	NOUN
admet-292	695	13	,	,	PUNCT
admet-292	695	14	and	and	CCONJ
admet-292	695	15	filtration	filtration	NOUN
admet-292	695	16	)	)	PUNCT
admet-292	695	17	can	can	AUX
admet-292	695	18	be	be	AUX
admet-292	695	19	used	use	VERB
admet-292	695	20	for	for	ADP
admet-292	695	21	the	the	DET
admet-292	695	22	separation	separation	NOUN
admet-292	695	23	of	of	ADP
admet-292	695	24	the	the	DET
admet-292	695	25	solid	solid	ADJ
admet-292	695	26	from	from	ADP
admet-292	695	27	the	the	DET
admet-292	695	28	saturated	saturate	VERB
admet-292	695	29	solution	solution	NOUN
admet-292	695	30	before	before	SCONJ
admet-292	695	31	aliquots	aliquot	NOUN
admet-292	695	32	can	can	AUX
admet-292	695	33	be	be	AUX
admet-292	695	34	taken	take	VERB
admet-292	695	35	out	out	ADP
admet-292	695	36	for	for	ADP
admet-292	695	37	concentration	concentration	NOUN
admet-292	695	38	measurement	measurement	NOUN
admet-292	695	39	.	.	PUNCT
admet-292	696	1	a	a	DET
admet-292	696	2	recent	recent	ADJ
admet-292	696	3	survey	survey	NOUN
admet-292	696	4	[	[	X
admet-292	696	5	4	4	X
admet-292	696	6	]	]	PUNCT
admet-292	696	7	showed	show	VERB
admet-292	696	8	that	that	SCONJ
admet-292	696	9	in	in	ADP
admet-292	696	10	majority	majority	NOUN
admet-292	696	11	of	of	ADP
admet-292	696	12	papers	paper	NOUN
admet-292	696	13	the	the	DET
admet-292	696	14	means	mean	NOUN
admet-292	696	15	of	of	ADP
admet-292	696	16	separation	separation	NOUN
admet-292	696	17	used	use	VERB
admet-292	696	18	has	have	AUX
admet-292	696	19	not	not	PART
admet-292	696	20	been	be	AUX
admet-292	696	21	indicated	indicate	VERB
admet-292	696	22	.	.	PUNCT
admet-292	697	1	where	where	SCONJ
admet-292	697	2	even	even	ADV
admet-292	697	3	declared	declare	VERB
admet-292	697	4	,	,	PUNCT
admet-292	697	5	the	the	DET
admet-292	697	6	filtration	filtration	NOUN
admet-292	697	7	was	be	AUX
admet-292	697	8	the	the	DET
admet-292	697	9	most	most	ADV
admet-292	697	10	frequent	frequent	ADJ
admet-292	697	11	method	method	NOUN
admet-292	697	12	(	(	PUNCT
admet-292	697	13	44	44	NUM
admet-292	697	14	%	%	NOUN
admet-292	697	15	)	)	PUNCT
admet-292	697	16	,	,	PUNCT
admet-292	697	17	while	while	SCONJ
admet-292	697	18	centrifugation	centrifugation	NOUN
admet-292	697	19	(	(	PUNCT
admet-292	697	20	14	14	NUM
admet-292	697	21	%	%	NOUN
admet-292	697	22	)	)	PUNCT
admet-292	697	23	and	and	CCONJ
admet-292	697	24	sedimentation	sedimentation	NOUN
admet-292	697	25	(	(	PUNCT
admet-292	697	26	9	9	NUM
admet-292	697	27	%	%	NOUN
admet-292	697	28	)	)	PUNCT
admet-292	697	29	were	be	AUX
admet-292	697	30	less	less	ADV
admet-292	697	31	used	use	VERB
admet-292	697	32	.	.	PUNCT
admet-292	698	1	in	in	ADP
admet-292	698	2	the	the	DET
admet-292	698	3	shake	shake	NOUN
admet-292	698	4	-	-	PUNCT
admet-292	698	5	flask	flask	NOUN
admet-292	698	6	method	method	NOUN
admet-292	698	7	,	,	PUNCT
admet-292	698	8	sedimentation	sedimentation	NOUN
admet-292	698	9	is	be	AUX
admet-292	698	10	the	the	DET
admet-292	698	11	primary	primary	ADJ
admet-292	698	12	method	method	NOUN
admet-292	698	13	of	of	ADP
admet-292	698	14	choice	choice	NOUN
admet-292	698	15	,	,	PUNCT
admet-292	698	16	because	because	SCONJ
admet-292	698	17	it	it	PRON
admet-292	698	18	assures	assure	VERB
admet-292	698	19	the	the	DET
admet-292	698	20	precondition	precondition	NOUN
admet-292	698	21	of	of	ADP
admet-292	698	22	dynamic	dynamic	ADJ
admet-292	698	23	solubility	solubility	NOUN
admet-292	698	24	equilibrium	equilibrium	NOUN
admet-292	698	25	,	,	PUNCT
admet-292	698	26	without	without	ADP
admet-292	698	27	disrupting	disrupt	VERB
admet-292	698	28	the	the	DET
admet-292	698	29	heterogeneous	heterogeneous	ADJ
admet-292	698	30	system	system	NOUN
admet-292	698	31	(	(	PUNCT
admet-292	698	32	see	see	VERB
admet-292	698	33	above	above	ADV
admet-292	698	34	)	)	PUNCT
admet-292	698	35	.	.	PUNCT
admet-292	699	1	at	at	ADP
admet-292	699	2	the	the	DET
admet-292	699	3	same	same	ADJ
admet-292	699	4	time	time	NOUN
admet-292	699	5	,	,	PUNCT
admet-292	699	6	direct	direct	ADJ
admet-292	699	7	sampling	sampling	NOUN
admet-292	699	8	from	from	ADP
admet-292	699	9	the	the	DET
admet-292	699	10	clear	clear	ADJ
admet-292	699	11	supernatant	supernatant	NOUN
admet-292	699	12	is	be	AUX
admet-292	699	13	simple	simple	ADJ
admet-292	699	14	and	and	CCONJ
admet-292	699	15	fast	fast	ADJ
admet-292	699	16	.	.	PUNCT
admet-292	700	1	the	the	DET
admet-292	700	2	aliquots	aliquot	NOUN
admet-292	700	3	taken	take	VERB
admet-292	700	4	out	out	ADP
admet-292	700	5	must	must	AUX
admet-292	700	6	be	be	AUX
admet-292	700	7	completely	completely	ADV
admet-292	700	8	transparent	transparent	ADJ
admet-292	700	9	,	,	PUNCT
admet-292	700	10	and	and	CCONJ
admet-292	700	11	free	free	ADJ
admet-292	700	12	of	of	ADP
admet-292	700	13	any	any	DET
admet-292	700	14	solid	solid	ADJ
admet-292	700	15	particles	particle	NOUN
admet-292	700	16	.	.	PUNCT
admet-292	701	1	if	if	SCONJ
admet-292	701	2	compound	compound	NOUN
admet-292	701	3	properties	property	NOUN
admet-292	701	4	hinder	hinder	VERB
admet-292	701	5	the	the	DET
admet-292	701	6	formation	formation	NOUN
admet-292	701	7	of	of	ADP
admet-292	701	8	clear	clear	ADJ
admet-292	701	9	recommendations	recommendation	NOUN
admet-292	701	10	for	for	ADP
admet-292	701	11	equilibration	equilibration	NOUN
admet-292	701	12	time	time	NOUN
admet-292	701	13	the	the	DET
admet-292	701	14	use	use	NOUN
admet-292	701	15	of	of	ADP
admet-292	701	16	intensive	intensive	ADJ
admet-292	701	17	stirring	stirring	NOUN
admet-292	701	18	for	for	ADP
admet-292	701	19	agitation	agitation	NOUN
admet-292	701	20	followed	follow	VERB
admet-292	701	21	by	by	ADP
admet-292	701	22	sedimentation	sedimentation	NOUN
admet-292	701	23	to	to	PART
admet-292	701	24	reach	reach	VERB
admet-292	701	25	the	the	DET
admet-292	701	26	solubility	solubility	NOUN
admet-292	701	27	equilibrium	equilibrium	NOUN
admet-292	701	28	is	be	AUX
admet-292	701	29	recommended	recommend	VERB
admet-292	701	30	.	.	PUNCT
admet-292	702	1	the	the	DET
admet-292	702	2	optimal	optimal	ADJ
admet-292	702	3	speed	speed	NOUN
admet-292	702	4	of	of	ADP
admet-292	702	5	the	the	DET
admet-292	702	6	stirrer	stirrer	NOUN
admet-292	702	7	depends	depend	VERB
admet-292	702	8	on	on	ADP
admet-292	702	9	the	the	DET
admet-292	702	10	volume	volume	NOUN
admet-292	702	11	of	of	ADP
admet-292	702	12	solubility	solubility	NOUN
admet-292	702	13	suspension	suspension	NOUN
admet-292	702	14	and	and	CCONJ
admet-292	702	15	the	the	DET
admet-292	702	16	characteristics	characteristic	NOUN
admet-292	702	17	of	of	ADP
admet-292	702	18	the	the	DET
admet-292	702	19	solid	solid	NOUN
admet-292	702	20	.	.	PUNCT
admet-292	703	1	it	it	PRON
admet-292	703	2	should	should	AUX
admet-292	703	3	provide	provide	VERB
admet-292	703	4	high	high	ADJ
admet-292	703	5	surface	surface	NOUN
admet-292	703	6	contacts	contact	NOUN
admet-292	703	7	of	of	ADP
admet-292	703	8	phases	phase	NOUN
admet-292	703	9	and	and	CCONJ
admet-292	703	10	avoid	avoid	VERB
admet-292	703	11	the	the	DET
admet-292	703	12	formation	formation	NOUN
admet-292	703	13	of	of	ADP
admet-292	703	14	stable	stable	ADJ
admet-292	703	15	colloid	colloid	NOUN
admet-292	703	16	system	system	NOUN
admet-292	703	17	.	.	PUNCT
admet-292	704	1	as	as	ADP
admet-292	704	2	a	a	DET
admet-292	704	3	good	good	ADJ
admet-292	704	4	average	average	ADJ
admet-292	704	5	time	time	NOUN
admet-292	704	6	of	of	ADP
admet-292	704	7	incubation	incubation	NOUN
admet-292	704	8	,	,	PUNCT
admet-292	704	9	24	24	NUM
admet-292	704	10	h	h	NOUN
admet-292	704	11	(	(	PUNCT
admet-292	704	12	6	6	NUM
admet-292	704	13	h	h	NOUN
admet-292	704	14	stirring	stirring	NOUN
admet-292	704	15	and	and	CCONJ
admet-292	704	16	18	18	NUM
admet-292	704	17	h	h	NOUN
admet-292	704	18	sedimentation	sedimentation	NOUN
admet-292	704	19	)	)	PUNCT
admet-292	704	20	can	can	AUX
admet-292	704	21	be	be	AUX
admet-292	704	22	recommended	recommend	VERB
admet-292	704	23	for	for	ADP
admet-292	704	24	overwhelming	overwhelming	ADJ
admet-292	704	25	majority	majority	NOUN
admet-292	704	26	of	of	ADP
admet-292	704	27	compounds	compound	NOUN
admet-292	704	28	.	.	PUNCT
admet-292	705	1	in	in	ADP
admet-292	705	2	case	case	NOUN
admet-292	705	3	of	of	ADP
admet-292	705	4	very	very	ADV
admet-292	705	5	sparingly	sparingly	ADV
admet-292	705	6	soluble	soluble	ADJ
admet-292	705	7	compounds	compound	NOUN
admet-292	705	8	,	,	PUNCT
admet-292	705	9	it	it	PRON
admet-292	705	10	is	be	AUX
admet-292	705	11	recommended	recommend	VERB
admet-292	705	12	that	that	SCONJ
admet-292	705	13	the	the	DET
admet-292	705	14	suitability	suitability	NOUN
admet-292	705	15	of	of	ADP
admet-292	705	16	the	the	DET
admet-292	705	17	selected	select	VERB
admet-292	705	18	equilibration	equilibration	NOUN
admet-292	705	19	time	time	NOUN
admet-292	705	20	be	be	AUX
admet-292	705	21	verified	verify	VERB
admet-292	705	22	.	.	PUNCT
admet-292	706	1	it	it	PRON
admet-292	706	2	is	be	AUX
admet-292	706	3	reasonable	reasonable	ADJ
admet-292	706	4	to	to	PART
admet-292	706	5	start	start	VERB
admet-292	706	6	with	with	ADP
admet-292	706	7	a	a	DET
admet-292	706	8	6	6	NUM
admet-292	706	9	h	h	NOUN
admet-292	706	10	stirring	stirring	NOUN
admet-292	706	11	time	time	NOUN
admet-292	706	12	,	,	PUNCT
admet-292	706	13	and	and	CCONJ
admet-292	706	14	check	check	VERB
admet-292	706	15	whether	whether	SCONJ
admet-292	706	16	the	the	DET
admet-292	706	17	sample	sample	NOUN
admet-292	706	18	concentration	concentration	NOUN
admet-292	706	19	is	be	AUX
admet-292	706	20	continuing	continue	VERB
admet-292	706	21	to	to	PART
admet-292	706	22	decrease	decrease	VERB
admet-292	706	23	at	at	ADP
admet-292	706	24	longer	long	ADJ
admet-292	706	25	times	time	NOUN
admet-292	706	26	.	.	PUNCT
admet-292	707	1	admet	admet	PROPN
admet-292	707	2	&	&	CCONJ
admet-292	707	3	dmpk	dmpk	PROPN
admet-292	707	4	4(2	4(2	NUM
admet-292	707	5	)	)	PUNCT
admet-292	707	6	(	(	PUNCT
admet-292	707	7	2016	2016	NUM
admet-292	707	8	)	)	PUNCT
admet-292	707	9	117	117	NUM
admet-292	707	10	-	-	SYM
admet-292	707	11	178	178	NUM
admet-292	707	12	consensus	consensus	NOUN
admet-292	707	13	recommendations	recommendation	NOUN
admet-292	707	14	for	for	ADP
admet-292	707	15	improving	improve	VERB
admet-292	707	16	solubility	solubility	NOUN
admet-292	707	17	-	-	PUNCT
admet-292	707	18	ph	ph	ADJ
admet-292	707	19	data	datum	NOUN
admet-292	707	20	quality	quality	NOUN
admet-292	707	21	doi	doi	NOUN
admet-292	707	22	:	:	PUNCT
admet-292	707	23	10.5599	10.5599	NUM
admet-292	707	24	/	/	SYM
admet-292	707	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	707	26	151	151	NUM
admet-292	707	27	solution	solution	NOUN
admet-292	707	28	upon	upon	SCONJ
admet-292	707	29	sedimentation	sedimentation	NOUN
admet-292	707	30	resulted	result	VERB
admet-292	707	31	in	in	ADP
admet-292	707	32	opalescent	opalescent	NOUN
admet-292	707	33	solution	solution	NOUN
admet-292	707	34	,	,	PUNCT
admet-292	707	35	centrifugation	centrifugation	NOUN
admet-292	707	36	can	can	AUX
admet-292	707	37	be	be	AUX
admet-292	707	38	the	the	DET
admet-292	707	39	alternative	alternative	ADJ
admet-292	707	40	separation	separation	NOUN
admet-292	707	41	method	method	NOUN
admet-292	707	42	.	.	PUNCT
admet-292	708	1	for	for	ADP
admet-292	708	2	such	such	ADJ
admet-292	708	3	samples	sample	NOUN
admet-292	708	4	centrifugation	centrifugation	NOUN
admet-292	708	5	at	at	ADP
admet-292	708	6	~1000	~1000	NUM
admet-292	708	7	g	g	NOUN
admet-292	708	8	(	(	PUNCT
admet-292	708	9	~2000	~2000	NUM
admet-292	708	10	rpm	rpm	NOUN
admet-292	708	11	)	)	PUNCT
admet-292	708	12	for	for	ADP
admet-292	708	13	10	10	NUM
admet-292	708	14	min	min	NOUN
admet-292	708	15	can	can	AUX
admet-292	708	16	be	be	AUX
admet-292	708	17	suggested	suggest	VERB
admet-292	708	18	.	.	PUNCT
admet-292	709	1	procedure	procedure	NOUN
admet-292	709	2	should	should	AUX
admet-292	709	3	be	be	AUX
admet-292	709	4	repeated	repeat	VERB
admet-292	709	5	if	if	SCONJ
admet-292	709	6	necessary	necessary	ADJ
admet-292	709	7	.	.	PUNCT
admet-292	710	1	surface	surface	NOUN
admet-292	710	2	adsorption	adsorption	NOUN
admet-292	710	3	by	by	ADP
admet-292	710	4	“	"	PUNCT
admet-292	710	5	just	just	ADV
admet-292	710	6	-	-	PUNCT
admet-292	710	7	saturated	saturated	ADJ
admet-292	710	8	”	"	PUNCT
admet-292	710	9	sample	sample	NOUN
admet-292	710	10	solution	solution	NOUN
admet-292	710	11	for	for	ADP
admet-292	710	12	some	some	DET
admet-292	710	13	compounds	compound	VERB
admet-292	710	14	the	the	DET
admet-292	710	15	adsorption	adsorption	NOUN
admet-292	710	16	to	to	ADP
admet-292	710	17	vials	vial	NOUN
admet-292	710	18	(	(	PUNCT
admet-292	710	19	glass	glass	NOUN
admet-292	710	20	or	or	CCONJ
admet-292	710	21	plastic	plastic	NOUN
admet-292	710	22	)	)	PUNCT
admet-292	710	23	is	be	AUX
admet-292	710	24	a	a	DET
admet-292	710	25	problem	problem	NOUN
admet-292	710	26	,	,	PUNCT
admet-292	710	27	especially	especially	ADV
admet-292	710	28	with	with	ADP
admet-292	710	29	lipophilic	lipophilic	ADJ
admet-292	710	30	bases	basis	NOUN
admet-292	710	31	and	and	CCONJ
admet-292	710	32	neutral	neutral	ADJ
admet-292	710	33	molecules	molecule	NOUN
admet-292	710	34	in	in	ADP
admet-292	710	35	weakly	weakly	ADJ
admet-292	710	36	buffered	buffer	VERB
admet-292	710	37	solutions	solution	NOUN
admet-292	710	38	,	,	PUNCT
admet-292	710	39	as	as	SCONJ
admet-292	710	40	described	describe	VERB
admet-292	710	41	by	by	ADP
admet-292	710	42	palmgrén	palmgrén	PROPN
admet-292	710	43	et	et	PROPN
admet-292	710	44	al	al	PROPN
admet-292	710	45	.	.	PUNCT
admet-292	711	1	[	[	X
admet-292	711	2	116	116	X
admet-292	711	3	]	]	PUNCT
admet-292	711	4	.	.	PUNCT
admet-292	712	1	it	it	PRON
admet-292	712	2	can	can	AUX
admet-292	712	3	be	be	AUX
admet-292	712	4	viewed	view	VERB
admet-292	712	5	as	as	ADP
admet-292	712	6	a	a	DET
admet-292	712	7	partitioning	partition	VERB
admet-292	712	8	phenomenon	phenomenon	NOUN
admet-292	712	9	.	.	PUNCT
admet-292	713	1	pretreatment	pretreatment	NOUN
admet-292	713	2	of	of	ADP
admet-292	713	3	the	the	DET
admet-292	713	4	vial	vial	ADJ
admet-292	713	5	surfaces	surface	NOUN
admet-292	713	6	with	with	ADP
admet-292	713	7	subsequently	subsequently	ADV
admet-292	713	8	-	-	PUNCT
admet-292	713	9	discarded	discard	VERB
admet-292	713	10	drug	drug	NOUN
admet-292	713	11	solution	solution	NOUN
admet-292	713	12	may	may	AUX
admet-292	713	13	be	be	AUX
admet-292	713	14	expected	expect	VERB
admet-292	713	15	to	to	PART
admet-292	713	16	saturate	saturate	VERB
admet-292	713	17	the	the	DET
admet-292	713	18	“	"	PUNCT
admet-292	713	19	binding	binding	ADJ
admet-292	713	20	”	"	PUNCT
admet-292	713	21	sites	site	NOUN
admet-292	713	22	on	on	ADP
admet-292	713	23	the	the	DET
admet-292	713	24	glass	glass	NOUN
admet-292	713	25	or	or	CCONJ
admet-292	713	26	plastic	plastic	NOUN
admet-292	713	27	surfaces	surface	NOUN
admet-292	713	28	,	,	PUNCT
admet-292	713	29	thus	thus	ADV
admet-292	713	30	potentially	potentially	ADV
admet-292	713	31	mitigating	mitigate	VERB
admet-292	713	32	the	the	DET
admet-292	713	33	problem	problem	NOUN
admet-292	713	34	in	in	ADP
admet-292	713	35	subsequent	subsequent	ADJ
admet-292	713	36	solution	solution	NOUN
admet-292	713	37	transfers	transfer	NOUN
admet-292	713	38	.	.	PUNCT
admet-292	714	1	in	in	ADP
admet-292	714	2	the	the	DET
admet-292	714	3	case	case	NOUN
admet-292	714	4	of	of	ADP
admet-292	714	5	practically	practically	ADV
admet-292	714	6	insoluble	insoluble	ADJ
admet-292	714	7	drugs	drug	NOUN
admet-292	714	8	,	,	PUNCT
admet-292	714	9	when	when	SCONJ
admet-292	714	10	solid	solid	ADJ
admet-292	714	11	is	be	AUX
admet-292	714	12	separated	separate	VERB
admet-292	714	13	from	from	ADP
admet-292	714	14	slurry	slurry	NOUN
admet-292	714	15	,	,	PUNCT
admet-292	714	16	the	the	DET
admet-292	714	17	resulting	result	VERB
admet-292	714	18	“	"	PUNCT
admet-292	714	19	just	just	ADV
admet-292	714	20	-	-	PUNCT
admet-292	714	21	saturated	saturated	ADJ
admet-292	714	22	”	"	PUNCT
admet-292	714	23	sample	sample	NOUN
admet-292	714	24	solution	solution	NOUN
admet-292	714	25	can	can	AUX
admet-292	714	26	decrease	decrease	VERB
admet-292	714	27	in	in	ADP
admet-292	714	28	concentration	concentration	NOUN
admet-292	714	29	with	with	ADP
admet-292	714	30	each	each	DET
admet-292	714	31	subsequent	subsequent	ADJ
admet-292	714	32	transfer	transfer	NOUN
admet-292	714	33	,	,	PUNCT
admet-292	714	34	as	as	SCONJ
admet-292	714	35	surface	surface	NOUN
admet-292	714	36	adsorption	adsorption	NOUN
admet-292	714	37	removes	remove	VERB
admet-292	714	38	some	some	PRON
admet-292	714	39	of	of	ADP
admet-292	714	40	the	the	DET
admet-292	714	41	compound	compound	NOUN
admet-292	714	42	from	from	ADP
admet-292	714	43	solution	solution	NOUN
admet-292	714	44	,	,	PUNCT
admet-292	714	45	taking	take	VERB
admet-292	714	46	the	the	DET
admet-292	714	47	system	system	NOUN
admet-292	714	48	further	far	ADV
admet-292	714	49	away	away	ADV
admet-292	714	50	from	from	ADP
admet-292	714	51	the	the	DET
admet-292	714	52	“	"	PUNCT
admet-292	714	53	just	just	ADV
admet-292	714	54	-	-	PUNCT
admet-292	714	55	saturated	saturated	ADJ
admet-292	714	56	”	"	PUNCT
admet-292	714	57	state	state	NOUN
admet-292	714	58	,	,	PUNCT
admet-292	714	59	since	since	SCONJ
admet-292	714	60	there	there	PRON
admet-292	714	61	is	be	VERB
admet-292	714	62	no	no	DET
admet-292	714	63	solid	solid	ADJ
admet-292	714	64	to	to	PART
admet-292	714	65	re	re	VERB
admet-292	714	66	-	-	VERB
admet-292	714	67	equilibrate	equilibrate	VERB
admet-292	714	68	the	the	DET
admet-292	714	69	perturbed	perturb	VERB
admet-292	714	70	solution	solution	NOUN
admet-292	714	71	.	.	PUNCT
admet-292	715	1	in	in	ADP
admet-292	715	2	filtration	filtration	NOUN
admet-292	715	3	,	,	PUNCT
admet-292	715	4	adsorption	adsorption	NOUN
admet-292	715	5	to	to	ADP
admet-292	715	6	filters	filter	NOUN
admet-292	715	7	is	be	AUX
admet-292	715	8	well	well	ADV
admet-292	715	9	recognized	recognize	VERB
admet-292	715	10	problem	problem	NOUN
admet-292	715	11	[	[	X
admet-292	715	12	117	117	NUM
admet-292	715	13	]	]	PUNCT
admet-292	715	14	.	.	PUNCT
admet-292	716	1	however	however	ADV
admet-292	716	2	,	,	PUNCT
admet-292	716	3	centrifugation	centrifugation	NOUN
admet-292	716	4	as	as	ADP
admet-292	716	5	a	a	DET
admet-292	716	6	method	method	NOUN
admet-292	716	7	for	for	ADP
admet-292	716	8	separating	separate	VERB
admet-292	716	9	solid	solid	ADV
admet-292	716	10	from	from	ADP
admet-292	716	11	saturated	saturated	ADJ
admet-292	716	12	solution	solution	NOUN
admet-292	716	13	is	be	AUX
admet-292	716	14	not	not	PART
admet-292	716	15	free	free	ADJ
admet-292	716	16	from	from	ADP
admet-292	716	17	similar	similar	ADJ
admet-292	716	18	adsorption	adsorption	NOUN
admet-292	716	19	effects	effect	NOUN
admet-292	716	20	.	.	PUNCT
admet-292	717	1	consider	consider	VERB
admet-292	717	2	the	the	DET
admet-292	717	3	bergström	bergström	NOUN
admet-292	717	4	et	et	PROPN
admet-292	717	5	al	al	PROPN
admet-292	717	6	.	.	PUNCT
admet-292	718	1	[	[	X
admet-292	718	2	118	118	NUM
admet-292	718	3	]	]	PUNCT
admet-292	718	4	study	study	NOUN
admet-292	718	5	where	where	SCONJ
admet-292	718	6	centrifugation	centrifugation	NOUN
admet-292	718	7	was	be	AUX
admet-292	718	8	done	do	VERB
admet-292	718	9	twice	twice	ADV
admet-292	718	10	:	:	PUNCT
admet-292	718	11	“	"	PUNCT
admet-292	718	12	the	the	DET
admet-292	718	13	excess	excess	ADJ
admet-292	718	14	solid	solid	NOUN
admet-292	718	15	was	be	AUX
admet-292	718	16	separated	separate	VERB
admet-292	718	17	from	from	ADP
admet-292	718	18	the	the	DET
admet-292	718	19	solution	solution	NOUN
admet-292	718	20	by	by	ADP
admet-292	718	21	centrifugation	centrifugation	NOUN
admet-292	718	22	at	at	ADP
admet-292	718	23	23	23	NUM
admet-292	718	24	000	000	NUM
admet-292	718	25	g	g	NOUN
admet-292	718	26	for	for	ADP
admet-292	718	27	15	15	NUM
admet-292	718	28	min	min	NOUN
admet-292	718	29	.	.	PROPN
admet-292	718	30	after	after	ADP
admet-292	718	31	the	the	DET
admet-292	718	32	centrifugation	centrifugation	NOUN
admet-292	718	33	,	,	PUNCT
admet-292	718	34	approximately	approximately	ADV
admet-292	718	35	0.25	0.25	NUM
admet-292	718	36	ml	ml	NOUN
admet-292	718	37	of	of	ADP
admet-292	718	38	the	the	DET
admet-292	718	39	supernatant	supernatant	NOUN
admet-292	718	40	was	be	AUX
admet-292	718	41	sampled	sample	VERB
admet-292	718	42	with	with	ADP
admet-292	718	43	pasteur	pasteur	NOUN
admet-292	718	44	glass	glass	NOUN
admet-292	718	45	pipettes	pipette	NOUN
admet-292	718	46	and	and	CCONJ
admet-292	718	47	dispensed	dispense	VERB
admet-292	718	48	into	into	ADP
admet-292	718	49	glass	glass	NOUN
admet-292	718	50	insert	insert	NOUN
admet-292	718	51	vials	vial	NOUN
admet-292	718	52	.	.	PUNCT
admet-292	719	1	these	these	DET
admet-292	719	2	vials	vial	NOUN
admet-292	719	3	were	be	AUX
admet-292	719	4	placed	place	VERB
admet-292	719	5	in	in	ADP
admet-292	719	6	eppendorf	eppendorf	PROPN
admet-292	719	7	tubes	tube	NOUN
admet-292	719	8	and	and	CCONJ
admet-292	719	9	centrifuged	centrifuge	VERB
admet-292	719	10	for	for	ADP
admet-292	719	11	15	15	NUM
admet-292	719	12	min	min	NOUN
admet-292	719	13	a	a	DET
admet-292	719	14	second	second	ADJ
admet-292	719	15	time	time	NOUN
admet-292	719	16	to	to	PART
admet-292	719	17	obtain	obtain	VERB
admet-292	719	18	complete	complete	ADJ
admet-292	719	19	separation	separation	NOUN
admet-292	719	20	of	of	ADP
admet-292	719	21	the	the	DET
admet-292	719	22	solution	solution	NOUN
admet-292	719	23	and	and	CCONJ
admet-292	719	24	the	the	DET
admet-292	719	25	remaining	remain	VERB
admet-292	719	26	solid	solid	NOUN
admet-292	719	27	.	.	PUNCT
admet-292	720	1	after	after	ADP
admet-292	720	2	the	the	DET
admet-292	720	3	centrifugation	centrifugation	NOUN
admet-292	720	4	,	,	PUNCT
admet-292	720	5	the	the	DET
admet-292	720	6	supernatant	supernatant	NOUN
admet-292	720	7	was	be	AUX
admet-292	720	8	withdrawn	withdraw	VERB
admet-292	720	9	with	with	ADP
admet-292	720	10	pasteur	pasteur	NOUN
admet-292	720	11	pipettes	pipette	NOUN
admet-292	720	12	and	and	CCONJ
admet-292	720	13	dispensed	dispense	VERB
admet-292	720	14	into	into	ADP
admet-292	720	15	glass	glass	NOUN
admet-292	720	16	hplc	hplc	NOUN
admet-292	720	17	vials	vial	NOUN
admet-292	720	18	.	.	PUNCT
admet-292	721	1	glass	glass	NOUN
admet-292	721	2	was	be	AUX
admet-292	721	3	used	use	VERB
admet-292	721	4	throughout	throughout	ADP
admet-292	721	5	this	this	DET
admet-292	721	6	procedure	procedure	NOUN
admet-292	721	7	to	to	PART
admet-292	721	8	minimize	minimize	VERB
admet-292	721	9	the	the	DET
admet-292	721	10	risk	risk	NOUN
admet-292	721	11	of	of	ADP
admet-292	721	12	underestimating	underestimate	VERB
admet-292	721	13	the	the	DET
admet-292	721	14	solubility	solubility	NOUN
admet-292	721	15	owing	owe	VERB
admet-292	721	16	to	to	ADP
admet-292	721	17	adsorption	adsorption	NOUN
admet-292	721	18	of	of	ADP
admet-292	721	19	the	the	DET
admet-292	721	20	drugs	drug	NOUN
admet-292	721	21	to	to	ADP
admet-292	721	22	plastics	plastic	NOUN
admet-292	721	23	.	.	PUNCT
admet-292	721	24	”	"	PUNCT
admet-292	722	1	it	it	PRON
admet-292	722	2	was	be	AUX
admet-292	722	3	not	not	PART
admet-292	722	4	explicitly	explicitly	ADV
admet-292	722	5	reported	report	VERB
admet-292	722	6	that	that	SCONJ
admet-292	722	7	the	the	DET
admet-292	722	8	pasteur	pasteur	NOUN
admet-292	722	9	glass	glass	NOUN
admet-292	722	10	pipettes	pipette	NOUN
admet-292	722	11	and	and	CCONJ
admet-292	722	12	hplc	hplc	NOUN
admet-292	722	13	vials	vial	NOUN
admet-292	722	14	were	be	AUX
admet-292	722	15	pre	pre	VERB
admet-292	722	16	-	-	VERB
admet-292	722	17	treated	treat	VERB
admet-292	722	18	with	with	ADP
admet-292	722	19	sample	sample	NOUN
admet-292	722	20	before	before	ADP
admet-292	722	21	use	use	NOUN
admet-292	722	22	.	.	PUNCT
admet-292	723	1	table	table	NOUN
admet-292	723	2	2	2	NUM
admet-292	723	3	lists	list	VERB
admet-292	723	4	the	the	DET
admet-292	723	5	intrinsic	intrinsic	ADJ
admet-292	723	6	solubility	solubility	NOUN
admet-292	723	7	values	value	NOUN
admet-292	723	8	of	of	ADP
admet-292	723	9	twelve	twelve	NUM
admet-292	723	10	practically	practically	ADV
admet-292	723	11	-	-	PUNCT
admet-292	723	12	insoluble	insoluble	ADJ
admet-292	723	13	drugs	drug	NOUN
admet-292	723	14	taken	take	VERB
admet-292	723	15	from	from	ADP
admet-292	723	16	the	the	DET
admet-292	723	17	above	above	ADJ
admet-292	723	18	study	study	NOUN
admet-292	723	19	,	,	PUNCT
admet-292	723	20	and	and	CCONJ
admet-292	723	21	compares	compare	VERB
admet-292	723	22	them	they	PRON
admet-292	723	23	to	to	ADP
admet-292	723	24	corresponding	correspond	VERB
admet-292	723	25	averaged	average	VERB
admet-292	723	26	intrinsic	intrinsic	ADJ
admet-292	723	27	solubilities	solubility	NOUN
admet-292	723	28	taken	take	VERB
admet-292	723	29	from	from	ADP
admet-292	723	30	other	other	ADJ
admet-292	723	31	published	publish	VERB
admet-292	723	32	studies	study	NOUN
admet-292	723	33	(	(	PUNCT
admet-292	723	34	with	with	ADP
admet-292	723	35	all	all	DET
admet-292	723	36	values	value	NOUN
admet-292	723	37	normalized	normalize	VERB
admet-292	723	38	to	to	ADP
admet-292	723	39	25	25	NUM
admet-292	723	40	°	°	NOUN
admet-292	723	41	c	c	NOUN
admet-292	723	42	[	[	X
admet-292	723	43	26	26	NUM
admet-292	723	44	]	]	NUM
admet-292	723	45	)	)	PUNCT
admet-292	723	46	.	.	PUNCT
admet-292	724	1	figure	figure	NOUN
admet-292	724	2	19	19	NUM
admet-292	724	3	is	be	AUX
admet-292	724	4	a	a	DET
admet-292	724	5	plot	plot	NOUN
admet-292	724	6	of	of	ADP
admet-292	724	7	the	the	DET
admet-292	724	8	above	above	ADJ
admet-292	724	9	comparison	comparison	NOUN
admet-292	724	10	.	.	PUNCT
admet-292	725	1	notably	notably	ADV
admet-292	725	2	,	,	PUNCT
admet-292	725	3	the	the	DET
admet-292	725	4	logs0	logs0	NOUN
admet-292	725	5	values	value	NOUN
admet-292	725	6	from	from	ADP
admet-292	725	7	[	[	X
admet-292	725	8	118	118	NUM
admet-292	725	9	]	]	PUNCT
admet-292	725	10	are	be	AUX
admet-292	725	11	1	1	NUM
admet-292	725	12	-	-	SYM
admet-292	725	13	3	3	NUM
admet-292	725	14	(	(	PUNCT
admet-292	725	15	or	or	CCONJ
admet-292	725	16	more	more	ADJ
admet-292	725	17	)	)	PUNCT
admet-292	725	18	log	log	NOUN
admet-292	725	19	units	unit	NOUN
admet-292	725	20	lower	low	ADJ
admet-292	725	21	than	than	ADP
admet-292	725	22	the	the	DET
admet-292	725	23	average	average	ADJ
admet-292	725	24	values	value	NOUN
admet-292	725	25	reported	report	VERB
admet-292	725	26	from	from	ADP
admet-292	725	27	other	other	ADJ
admet-292	725	28	published	publish	VERB
admet-292	725	29	studies	study	NOUN
admet-292	725	30	,	,	PUNCT
admet-292	725	31	with	with	ADP
admet-292	725	32	the	the	DET
admet-292	725	33	exception	exception	NOUN
admet-292	725	34	of	of	ADP
admet-292	725	35	that	that	PRON
admet-292	725	36	of	of	ADP
admet-292	725	37	itraconazole	itraconazole	PROPN
admet-292	725	38	.	.	PUNCT
admet-292	726	1	although	although	SCONJ
admet-292	726	2	there	there	PRON
admet-292	726	3	may	may	AUX
admet-292	726	4	be	be	AUX
admet-292	726	5	a	a	DET
admet-292	726	6	number	number	NOUN
admet-292	726	7	of	of	ADP
admet-292	726	8	plausible	plausible	ADJ
admet-292	726	9	explanations	explanation	NOUN
admet-292	726	10	for	for	ADP
admet-292	726	11	the	the	DET
admet-292	726	12	differences	difference	NOUN
admet-292	726	13	,	,	PUNCT
admet-292	726	14	it	it	PRON
admet-292	726	15	might	might	AUX
admet-292	726	16	be	be	AUX
admet-292	726	17	useful	useful	ADJ
admet-292	726	18	to	to	PART
admet-292	726	19	consider	consider	VERB
admet-292	726	20	the	the	DET
admet-292	726	21	possibility	possibility	NOUN
admet-292	726	22	that	that	SCONJ
admet-292	726	23	the	the	DET
admet-292	726	24	double	double	ADJ
admet-292	726	25	-	-	PUNCT
admet-292	726	26	centrifugation	centrifugation	NOUN
admet-292	726	27	step	step	NOUN
admet-292	726	28	led	lead	VERB
admet-292	726	29	to	to	ADP
admet-292	726	30	under	under	ADV
admet-292	726	31	-	-	PUNCT
admet-292	726	32	estimated	estimate	VERB
admet-292	726	33	solubility	solubility	NOUN
admet-292	726	34	,	,	PUNCT
admet-292	726	35	due	due	ADP
admet-292	726	36	to	to	ADP
admet-292	726	37	adsorption	adsorption	NOUN
admet-292	726	38	to	to	ADP
admet-292	726	39	the	the	DET
admet-292	726	40	glass	glass	NOUN
admet-292	726	41	surfaces	surface	NOUN
admet-292	726	42	of	of	ADP
admet-292	726	43	the	the	DET
admet-292	726	44	transfer	transfer	NOUN
admet-292	726	45	vials	vial	NOUN
admet-292	726	46	.	.	PUNCT
admet-292	727	1	in	in	ADP
admet-292	727	2	the	the	DET
admet-292	727	3	case	case	NOUN
admet-292	727	4	of	of	ADP
admet-292	727	5	itraconazole	itraconazole	NOUN
admet-292	727	6	,	,	PUNCT
admet-292	727	7	the	the	DET
admet-292	727	8	value	value	NOUN
admet-292	727	9	reported	report	VERB
admet-292	727	10	by	by	ADP
admet-292	727	11	glomme	glomme	PROPN
admet-292	727	12	et	et	PROPN
admet-292	727	13	al	al	PROPN
admet-292	727	14	.	.	PUNCT
admet-292	728	1	[	[	X
admet-292	728	2	117	117	NUM
admet-292	728	3	]	]	X
admet-292	728	4	may	may	AUX
admet-292	728	5	have	have	AUX
admet-292	728	6	had	have	VERB
admet-292	728	7	more	more	ADJ
admet-292	728	8	adsorption	adsorption	NOUN
admet-292	728	9	than	than	ADP
admet-292	728	10	even	even	ADV
admet-292	728	11	in	in	ADP
admet-292	728	12	[	[	X
admet-292	728	13	118	118	NUM
admet-292	728	14	]	]	PUNCT
admet-292	728	15	.	.	PUNCT
admet-292	729	1	the	the	DET
admet-292	729	2	former	former	ADJ
admet-292	729	3	group	group	NOUN
admet-292	729	4	used	use	VERB
admet-292	729	5	plastic	plastic	NOUN
admet-292	729	6	uniprep	uniprep	ADJ
admet-292	729	7	filter	filter	NOUN
admet-292	729	8	vials	vial	NOUN
admet-292	729	9	:	:	PUNCT
admet-292	729	10	“	"	PUNCT
admet-292	729	11	even	even	ADV
admet-292	729	12	with	with	ADP
admet-292	729	13	the	the	DET
admet-292	729	14	uniprep	uniprep	ADJ
admet-292	729	15	filters	filter	NOUN
admet-292	729	16	,	,	PUNCT
admet-292	729	17	a	a	DET
admet-292	729	18	loss	loss	NOUN
admet-292	729	19	of	of	ADP
admet-292	729	20	drug	drug	NOUN
admet-292	729	21	can	can	AUX
admet-292	729	22	sometimes	sometimes	ADV
admet-292	729	23	occur	occur	VERB
admet-292	729	24	through	through	ADP
admet-292	729	25	adsorption	adsorption	NOUN
admet-292	729	26	on	on	ADP
admet-292	729	27	the	the	DET
admet-292	729	28	filter	filter	NOUN
admet-292	729	29	membrane	membrane	NOUN
admet-292	729	30	.	.	PUNCT
admet-292	730	1	for	for	ADP
admet-292	730	2	that	that	DET
admet-292	730	3	reason	reason	NOUN
admet-292	730	4	,	,	PUNCT
admet-292	730	5	the	the	DET
admet-292	730	6	first	first	ADJ
admet-292	730	7	drops	drop	NOUN
admet-292	730	8	of	of	ADP
admet-292	730	9	the	the	DET
admet-292	730	10	filtrate	filtrate	NOUN
admet-292	730	11	should	should	AUX
admet-292	730	12	be	be	AUX
admet-292	730	13	discarded	discard	VERB
admet-292	730	14	.	.	PUNCT
admet-292	730	15	”	"	PUNCT
admet-292	731	1	combining	combine	VERB
admet-292	731	2	centrifugation	centrifugation	NOUN
admet-292	731	3	with	with	ADP
admet-292	731	4	filtration	filtration	NOUN
admet-292	731	5	it	it	PRON
admet-292	731	6	is	be	AUX
admet-292	731	7	potentially	potentially	ADV
admet-292	731	8	a	a	DET
admet-292	731	9	faulty	faulty	ADJ
admet-292	731	10	procedure	procedure	NOUN
admet-292	731	11	,	,	PUNCT
admet-292	731	12	when	when	SCONJ
admet-292	731	13	separating	separate	VERB
admet-292	731	14	solid	solid	ADV
admet-292	731	15	from	from	ADP
admet-292	731	16	solution	solution	NOUN
admet-292	731	17	:	:	PUNCT
admet-292	731	18	to	to	PART
admet-292	731	19	centrifuge	centrifuge	VERB
admet-292	731	20	the	the	DET
admet-292	731	21	suspension	suspension	NOUN
admet-292	731	22	first	first	ADV
admet-292	731	23	and	and	CCONJ
admet-292	731	24	then	then	ADV
admet-292	731	25	subject	subject	VERB
admet-292	731	26	the	the	DET
admet-292	731	27	centrifugate	centrifugate	NOUN
admet-292	731	28	to	to	ADP
admet-292	731	29	a	a	DET
admet-292	731	30	further	further	ADJ
admet-292	731	31	filtration	filtration	NOUN
admet-292	731	32	step	step	NOUN
admet-292	731	33	.	.	PUNCT
admet-292	732	1	the	the	DET
admet-292	732	2	reason	reason	NOUN
admet-292	732	3	is	be	AUX
admet-292	732	4	very	very	ADV
admet-292	732	5	simple	simple	ADJ
admet-292	732	6	:	:	PUNCT
admet-292	732	7	once	once	SCONJ
admet-292	732	8	the	the	DET
admet-292	732	9	solid	solid	ADJ
admet-292	732	10	is	be	AUX
admet-292	732	11	removed	remove	VERB
admet-292	732	12	,	,	PUNCT
admet-292	732	13	a	a	DET
admet-292	732	14	“	"	PUNCT
admet-292	732	15	just	just	ADV
admet-292	732	16	-	-	PUNCT
admet-292	732	17	saturated	saturated	ADJ
admet-292	732	18	”	"	PUNCT
admet-292	732	19	solution	solution	NOUN
admet-292	732	20	has	have	VERB
admet-292	732	21	no	no	DET
admet-292	732	22	capacity	capacity	NOUN
admet-292	732	23	to	to	PART
admet-292	732	24	re	re	VERB
admet-292	732	25	-	-	VERB
admet-292	732	26	establish	establish	VERB
admet-292	732	27	equilibrium	equilibrium	NOUN
admet-292	732	28	when	when	SCONJ
admet-292	732	29	exposed	expose	VERB
admet-292	732	30	to	to	ADP
admet-292	732	31	the	the	DET
admet-292	732	32	surface	surface	NOUN
admet-292	732	33	of	of	ADP
admet-292	732	34	a	a	DET
admet-292	732	35	filter	filter	NOUN
admet-292	732	36	,	,	PUNCT
admet-292	732	37	where	where	SCONJ
admet-292	732	38	adsorption	adsorption	NOUN
admet-292	732	39	usually	usually	ADV
admet-292	732	40	takes	take	VERB
admet-292	732	41	place	place	NOUN
admet-292	732	42	to	to	ADP
admet-292	732	43	some	some	DET
admet-292	732	44	extent	extent	NOUN
admet-292	732	45	,	,	PUNCT
admet-292	732	46	and	and	CCONJ
admet-292	732	47	can	can	AUX
admet-292	732	48	account	account	VERB
admet-292	732	49	for	for	ADP
admet-292	732	50	a	a	DET
admet-292	732	51	large	large	ADJ
admet-292	732	52	fraction	fraction	NOUN
admet-292	732	53	of	of	ADP
admet-292	732	54	the	the	DET
admet-292	732	55	mass	mass	NOUN
admet-292	732	56	of	of	ADP
admet-292	732	57	a	a	DET
admet-292	732	58	practically	practically	ADV
admet-292	732	59	-	-	PUNCT
admet-292	732	60	insoluble	insoluble	ADJ
admet-292	732	61	compound	compound	NOUN
admet-292	732	62	.	.	PUNCT
admet-292	733	1	alex	alex	PROPN
admet-292	733	2	avdeef	avdeef	PROPN
admet-292	733	3	et	et	PROPN
admet-292	733	4	al	al	PROPN
admet-292	733	5	.	.	PROPN
admet-292	733	6	admet	admet	PROPN
admet-292	733	7	&	&	CCONJ
admet-292	733	8	dmpk	dmpk	PROPN
admet-292	733	9	4(2	4(2	NUM
admet-292	733	10	)	)	PUNCT
admet-292	733	11	(	(	PUNCT
admet-292	733	12	2016	2016	NUM
admet-292	733	13	)	)	PUNCT
admet-292	733	14	117	117	NUM
admet-292	733	15	-	-	SYM
admet-292	733	16	178	178	NUM
admet-292	733	17	152	152	NUM
admet-292	733	18	table	table	NOUN
admet-292	733	19	2	2	NUM
admet-292	733	20	.	.	PUNCT
admet-292	733	21	potential	potential	ADJ
admet-292	733	22	sample	sample	NOUN
admet-292	733	23	loss	loss	NOUN
admet-292	733	24	due	due	ADP
admet-292	733	25	to	to	ADP
admet-292	733	26	adsorption	adsorption	NOUN
admet-292	733	27	in	in	ADP
admet-292	733	28	multiple	multiple	ADJ
admet-292	733	29	transfers	transfer	NOUN
admet-292	733	30	drug	drug	NOUN
admet-292	733	31	logs0	logs0	PROPN
admet-292	734	1	a	a	DET
admet-292	734	2	sd	sd	X
admet-292	734	3	logs0	logs0	PROPN
admet-292	735	1	b	b	SYM
admet-292	735	2	sd	sd	ADP
admet-292	735	3	c	c	PROPN
admet-292	735	4	lit	light	VERB
admet-292	735	5	.	.	PUNCT
admet-292	736	1	refs	ref	NOUN
admet-292	736	2	.	.	PUNCT
admet-292	737	1	albendazole	albendazole	PROPN
admet-292	737	2	-6.01	-6.01	NUM
admet-292	737	3	0.05	0.05	NUM
admet-292	737	4	-5.65	-5.65	ADP
admet-292	737	5	0.15	0.15	NUM
admet-292	738	1	[	[	X
admet-292	738	2	119	119	NUM
admet-292	738	3	,	,	PUNCT
admet-292	738	4	120	120	NUM
admet-292	738	5	]	]	X
admet-292	738	6	carvedilol	carvedilol	PROPN
admet-292	738	7	-6.15	-6.15	NUM
admet-292	738	8	0.03	0.03	NUM
admet-292	738	9	-5.32	-5.32	NUM
admet-292	738	10	0.50	0.50	NUM
admet-292	739	1	[	[	X
admet-292	739	2	48	48	NUM
admet-292	739	3	,	,	PUNCT
admet-292	739	4	121	121	NUM
admet-292	739	5	-	-	SYM
admet-292	739	6	124	124	NUM
admet-292	739	7	]	]	PUNCT
admet-292	739	8	cinnarizine	cinnarizine	NOUN
admet-292	739	9	-7.73	-7.73	NUM
admet-292	739	10	0.04	0.04	NUM
admet-292	739	11	-7.14	-7.14	NOUN
admet-292	739	12	0.28	0.28	NUM
admet-292	739	13	[	[	X
admet-292	739	14	27	27	NUM
admet-292	739	15	,	,	PUNCT
admet-292	739	16	125,126	125,126	NUM
admet-292	739	17	]	]	PUNCT
admet-292	739	18	danazol	danazol	ADJ
admet-292	739	19	-7.44	-7.44	NUM
admet-292	739	20	0.34	0.34	NUM
admet-292	739	21	-6.02	-6.02	NUM
admet-292	739	22	0.28	0.28	NUM
admet-292	740	1	[	[	X
admet-292	740	2	117,125,127	117,125,127	NUM
admet-292	740	3	-	-	SYM
admet-292	740	4	130	130	NUM
admet-292	740	5	]	]	PUNCT
admet-292	740	6	felodipine	felodipine	VERB
admet-292	740	7	-6.56	-6.56	NUM
admet-292	740	8	0.03	0.03	NUM
admet-292	740	9	-5.77	-5.77	NUM
admet-292	740	10	0.10	0.10	NUM
admet-292	740	11	[	[	X
admet-292	740	12	117,131,132	117,131,132	NUM
admet-292	740	13	]	]	X
admet-292	740	14	glimepiride	glimepiride	NOUN
admet-292	740	15	-7.90	-7.90	NUM
admet-292	740	16	0.10	0.10	NUM
admet-292	740	17	-6.85	-6.85	NUM
admet-292	740	18	0.36	0.36	NUM
admet-292	740	19	[	[	SYM
admet-292	740	20	133	133	NUM
admet-292	740	21	-	-	SYM
admet-292	740	22	135	135	NUM
admet-292	740	23	]	]	PUNCT
admet-292	740	24	itraconazole	itraconazole	NOUN
admet-292	740	25	-8.48	-8.48	NUM
admet-292	740	26	0.61	0.61	NUM
admet-292	740	27	-9.67	-9.67	NUM
admet-292	740	28	-	-	SYM
admet-292	740	29	d	d	NOUN
admet-292	741	1	[	[	X
admet-292	741	2	117	117	NUM
admet-292	741	3	]	]	X
admet-292	741	4	rimonabant	rimonabant	PROPN
admet-292	741	5	-7.02	-7.02	NUM
admet-292	741	6	0.06	0.06	NUM
admet-292	741	7	-6.35	-6.35	NUM
admet-292	741	8	-	-	PUNCT
admet-292	741	9	d	d	NOUN
admet-292	742	1	[	[	X
admet-292	742	2	136	136	NUM
admet-292	742	3	]	]	PUNCT
admet-292	742	4	tamoxifen	tamoxifen	NOUN
admet-292	742	5	-8.54	-8.54	NUM
admet-292	742	6	0.15	0.15	NUM
admet-292	742	7	-7.54	-7.54	NUM
admet-292	742	8	0.72	0.72	NUM
admet-292	743	1	[	[	PUNCT
admet-292	743	2	137	137	NUM
admet-292	743	3	-	-	SYM
admet-292	743	4	140	140	NUM
admet-292	743	5	]	]	PUNCT
admet-292	743	6	terfenadine	terfenadine	X
admet-292	743	7	-7.94	-7.94	X
admet-292	743	8	0.27	0.27	NUM
admet-292	743	9	-6.99	-6.99	NOUN
admet-292	743	10	1.05	1.05	NUM
admet-292	743	11	[	[	X
admet-292	743	12	2,21,110	2,21,110	ADJ
admet-292	743	13	,	,	PUNCT
admet-292	743	14	141	141	NUM
admet-292	743	15	-	-	SYM
admet-292	743	16	147	147	NUM
admet-292	743	17	]	]	PUNCT
admet-292	743	18	tolfenamic	tolfenamic	ADJ
admet-292	743	19	acid	acid	NOUN
admet-292	743	20	-7.87	-7.87	VERB
admet-292	743	21	0.05	0.05	NUM
admet-292	743	22	-6.16	-6.16	NUM
admet-292	743	23	-	-	PUNCT
admet-292	743	24	d	d	NOUN
admet-292	744	1	[	[	X
admet-292	744	2	137	137	NUM
admet-292	744	3	]	]	X
admet-292	744	4	troglitazone	troglitazone	NOUN
admet-292	744	5	-7.80	-7.80	NOUN
admet-292	744	6	0.43	0.43	NUM
admet-292	744	7	-5.34	-5.34	NOUN
admet-292	744	8	0.78	0.78	NUM
admet-292	745	1	[	[	X
admet-292	745	2	148,149	148,149	NUM
admet-292	745	3	]	]	X
admet-292	745	4	a	a	DET
admet-292	745	5	solid	solid	ADJ
admet-292	745	6	separated	separate	VERB
admet-292	745	7	from	from	ADP
admet-292	745	8	slurry	slurry	NOUN
admet-292	745	9	by	by	ADP
admet-292	745	10	two	two	NUM
admet-292	745	11	centrifugations	centrifugation	NOUN
admet-292	745	12	[	[	X
admet-292	745	13	118	118	NUM
admet-292	745	14	]	]	PUNCT
admet-292	745	15	.	.	PUNCT
admet-292	746	1	b	b	NOUN
admet-292	746	2	averaged	average	VERB
admet-292	746	3	for	for	ADP
admet-292	746	4	the	the	DET
admet-292	746	5	corresponding	corresponding	ADJ
admet-292	746	6	drugs	drug	NOUN
admet-292	746	7	from	from	ADP
admet-292	746	8	other	other	ADJ
admet-292	746	9	published	publish	VERB
admet-292	746	10	sources	source	NOUN
admet-292	746	11	;	;	PUNCT
admet-292	746	12	values	value	NOUN
admet-292	746	13	transformed	transform	VERB
admet-292	746	14	to	to	ADP
admet-292	746	15	25	25	NUM
admet-292	746	16	°	°	NOUN
admet-292	746	17	c	c	NOUN
admet-292	746	18	before	before	ADP
admet-292	746	19	averaging	average	VERB
admet-292	746	20	.	.	PUNCT
admet-292	747	1	c	c	PROPN
admet-292	747	2	interlaboratory	interlaboratory	ADJ
admet-292	747	3	standard	standard	ADJ
admet-292	747	4	deviations	deviation	NOUN
admet-292	747	5	,	,	PUNCT
admet-292	747	6	with	with	ADP
admet-292	747	7	references	reference	NOUN
admet-292	747	8	in	in	ADP
admet-292	747	9	the	the	DET
admet-292	747	10	last	last	ADJ
admet-292	747	11	column	column	NOUN
admet-292	747	12	.	.	PUNCT
admet-292	748	1	d	d	X
admet-292	748	2	single	single	ADJ
admet-292	748	3	source	source	NOUN
admet-292	748	4	comparison	comparison	NOUN
admet-292	748	5	.	.	PUNCT
admet-292	749	1	filtration	filtration	NOUN
admet-292	749	2	solubility	solubility	NOUN
admet-292	749	3	suspensions	suspension	NOUN
admet-292	749	4	which	which	PRON
admet-292	749	5	fail	fail	VERB
admet-292	749	6	to	to	PART
admet-292	749	7	clarify	clarify	VERB
admet-292	749	8	or	or	CCONJ
admet-292	749	9	sediment	sediment	NOUN
admet-292	749	10	,	,	PUNCT
admet-292	749	11	must	must	AUX
admet-292	749	12	be	be	AUX
admet-292	749	13	filtered	filter	VERB
admet-292	749	14	through	through	ADP
admet-292	749	15	membrane	membrane	NOUN
admet-292	749	16	or	or	CCONJ
admet-292	749	17	glass	glass	NOUN
admet-292	749	18	filter	filter	NOUN
admet-292	749	19	.	.	PUNCT
admet-292	750	1	filtration	filtration	NOUN
admet-292	750	2	should	should	AUX
admet-292	750	3	not	not	PART
admet-292	750	4	be	be	AUX
admet-292	750	5	done	do	VERB
admet-292	750	6	right	right	ADV
admet-292	750	7	after	after	ADP
admet-292	750	8	stirring	stir	VERB
admet-292	750	9	,	,	PUNCT
admet-292	750	10	since	since	SCONJ
admet-292	750	11	the	the	DET
admet-292	750	12	formation	formation	NOUN
admet-292	750	13	of	of	ADP
admet-292	750	14	a	a	DET
admet-292	750	15	supersaturated	supersaturated	ADJ
admet-292	750	16	solution	solution	NOUN
admet-292	750	17	upon	upon	SCONJ
admet-292	750	18	intensive	intensive	ADJ
admet-292	750	19	agitation	agitation	NOUN
admet-292	750	20	may	may	AUX
admet-292	750	21	lead	lead	VERB
admet-292	750	22	to	to	ADP
admet-292	750	23	an	an	DET
admet-292	750	24	overestimated	overestimated	ADJ
admet-292	750	25	solubility	solubility	NOUN
admet-292	750	26	.	.	PUNCT
admet-292	751	1	since	since	SCONJ
admet-292	751	2	majority	majority	NOUN
admet-292	751	3	of	of	ADP
admet-292	751	4	compounds	compound	NOUN
admet-292	751	5	are	be	AUX
admet-292	751	6	inclined	incline	VERB
admet-292	751	7	to	to	PART
admet-292	751	8	supersaturation	supersaturation	VERB
admet-292	751	9	,	,	PUNCT
admet-292	751	10	it	it	PRON
admet-292	751	11	is	be	AUX
admet-292	751	12	recommended	recommend	VERB
admet-292	751	13	to	to	PART
admet-292	751	14	allow	allow	VERB
admet-292	751	15	the	the	DET
admet-292	751	16	sample	sample	NOUN
admet-292	751	17	standing	stand	VERB
admet-292	751	18	after	after	ADP
admet-292	751	19	stirring	stir	VERB
admet-292	751	20	(	(	PUNCT
admet-292	751	21	as	as	SCONJ
admet-292	751	22	done	do	VERB
admet-292	751	23	in	in	ADP
admet-292	751	24	the	the	DET
admet-292	751	25	sedimentation	sedimentation	NOUN
admet-292	751	26	technique	technique	NOUN
admet-292	751	27	)	)	PUNCT
admet-292	751	28	to	to	PART
admet-292	751	29	avoid	avoid	VERB
admet-292	751	30	this	this	DET
admet-292	751	31	problem	problem	NOUN
admet-292	751	32	.	.	PUNCT
admet-292	752	1	another	another	DET
admet-292	752	2	source	source	NOUN
admet-292	752	3	of	of	ADP
admet-292	752	4	error	error	NOUN
admet-292	752	5	using	use	VERB
admet-292	752	6	filtration	filtration	NOUN
admet-292	752	7	is	be	AUX
admet-292	752	8	the	the	DET
admet-292	752	9	possible	possible	ADJ
admet-292	752	10	adsorption	adsorption	NOUN
admet-292	752	11	of	of	ADP
admet-292	752	12	the	the	DET
admet-292	752	13	solid	solid	NOUN
admet-292	752	14	to	to	ADP
admet-292	752	15	the	the	DET
admet-292	752	16	filter	filter	NOUN
admet-292	752	17	material	material	NOUN
admet-292	752	18	,	,	PUNCT
admet-292	752	19	as	as	SCONJ
admet-292	752	20	just	just	ADV
admet-292	752	21	described	describe	VERB
admet-292	752	22	.	.	PUNCT
admet-292	753	1	this	this	PRON
admet-292	753	2	can	can	AUX
admet-292	753	3	be	be	AUX
admet-292	753	4	substantially	substantially	ADV
admet-292	753	5	reduced	reduce	VERB
admet-292	753	6	or	or	CCONJ
admet-292	753	7	eliminated	eliminate	VERB
admet-292	753	8	by	by	ADP
admet-292	753	9	pre	pre	VERB
admet-292	753	10	-	-	ADJ
admet-292	753	11	saturating	saturate	VERB
admet-292	753	12	the	the	DET
admet-292	753	13	filter	filter	NOUN
admet-292	753	14	and	and	CCONJ
admet-292	753	15	discarding	discard	VERB
admet-292	753	16	the	the	DET
admet-292	753	17	initial	initial	ADJ
admet-292	753	18	portions	portion	NOUN
admet-292	753	19	of	of	ADP
admet-292	753	20	filtrate	filtrate	NOUN
admet-292	753	21	.	.	PUNCT
admet-292	754	1	less	less	ADJ
admet-292	754	2	attention	attention	NOUN
admet-292	754	3	was	be	AUX
admet-292	754	4	devoted	devote	VERB
admet-292	754	5	in	in	ADP
admet-292	754	6	the	the	DET
admet-292	754	7	literature	literature	NOUN
admet-292	754	8	to	to	ADP
admet-292	754	9	the	the	DET
admet-292	754	10	proper	proper	ADJ
admet-292	754	11	filter	filter	NOUN
admet-292	754	12	type	type	NOUN
admet-292	754	13	selection	selection	NOUN
admet-292	754	14	.	.	PUNCT
admet-292	755	1	a	a	DET
admet-292	755	2	recent	recent	ADJ
admet-292	755	3	study	study	NOUN
admet-292	755	4	has	have	AUX
admet-292	755	5	revealed	reveal	VERB
admet-292	755	6	the	the	DET
admet-292	755	7	significant	significant	ADJ
admet-292	755	8	role	role	NOUN
admet-292	755	9	of	of	ADP
admet-292	755	10	hydrophilic	hydrophilic	ADJ
admet-292	755	11	or	or	CCONJ
admet-292	755	12	hydrophobic	hydrophobic	NOUN
admet-292	755	13	type	type	NOUN
admet-292	755	14	of	of	ADP
admet-292	755	15	filters	filter	NOUN
admet-292	755	16	on	on	ADP
admet-292	755	17	the	the	DET
admet-292	755	18	solubility	solubility	NOUN
admet-292	755	19	results	result	NOUN
admet-292	755	20	of	of	ADP
admet-292	755	21	ionizable	ionizable	ADJ
admet-292	755	22	molecules	molecule	NOUN
admet-292	755	23	[	[	X
admet-292	755	24	150	150	NUM
admet-292	755	25	]	]	PUNCT
admet-292	755	26	.	.	PUNCT
admet-292	756	1	the	the	DET
admet-292	756	2	selection	selection	NOUN
admet-292	756	3	of	of	ADP
admet-292	756	4	appropriate	appropriate	ADJ
admet-292	756	5	filter	filter	NOUN
admet-292	756	6	type	type	NOUN
admet-292	756	7	requires	require	VERB
admet-292	756	8	some	some	DET
admet-292	756	9	knowledge	knowledge	NOUN
admet-292	756	10	of	of	ADP
admet-292	756	11	the	the	DET
admet-292	756	12	acid	acid	NOUN
admet-292	756	13	-	-	PUNCT
admet-292	756	14	base	base	NOUN
admet-292	756	15	chemistry	chemistry	NOUN
admet-292	756	16	of	of	ADP
admet-292	756	17	the	the	DET
admet-292	756	18	sample	sample	NOUN
admet-292	756	19	.	.	PUNCT
admet-292	757	1	for	for	ADP
admet-292	757	2	the	the	DET
admet-292	757	3	filtration	filtration	NOUN
admet-292	757	4	of	of	ADP
admet-292	757	5	the	the	DET
admet-292	757	6	ionized	ionized	ADJ
admet-292	757	7	form	form	NOUN
admet-292	757	8	of	of	ADP
admet-292	757	9	the	the	DET
admet-292	757	10	compound	compound	NOUN
admet-292	757	11	,	,	PUNCT
admet-292	757	12	hydrophobic	hydrophobic	NOUN
admet-292	757	13	filter	filter	NOUN
admet-292	757	14	can	can	AUX
admet-292	757	15	be	be	AUX
admet-292	757	16	recommended	recommend	VERB
admet-292	757	17	.	.	PUNCT
admet-292	758	1	for	for	ADP
admet-292	758	2	unionized	unionized	ADJ
admet-292	758	3	drugs	drug	NOUN
admet-292	758	4	,	,	PUNCT
admet-292	758	5	the	the	DET
admet-292	758	6	uncharged	uncharged	ADJ
admet-292	758	7	-	-	PUNCT
admet-292	758	8	form	form	NOUN
admet-292	758	9	hydrophilic	hydrophilic	ADJ
admet-292	758	10	filter	filter	NOUN
admet-292	758	11	can	can	AUX
admet-292	758	12	be	be	AUX
admet-292	758	13	recommended	recommend	VERB
admet-292	758	14	.	.	PUNCT
admet-292	759	1	these	these	DET
admet-292	759	2	suggestions	suggestion	NOUN
admet-292	759	3	can	can	AUX
admet-292	759	4	be	be	AUX
admet-292	759	5	supported	support	VERB
admet-292	759	6	by	by	ADP
admet-292	759	7	the	the	DET
admet-292	759	8	solubility	solubility	NOUN
admet-292	759	9	results	result	NOUN
admet-292	759	10	of	of	ADP
admet-292	759	11	papaverine	papaverine	NOUN
admet-292	759	12	(	(	PUNCT
admet-292	759	13	pka	pka	NOUN
admet-292	759	14	6.39	6.39	NUM
admet-292	759	15	)	)	PUNCT
admet-292	759	16	measured	measure	VERB
admet-292	759	17	at	at	ADP
admet-292	759	18	three	three	NUM
admet-292	759	19	ph	ph	ADJ
admet-292	759	20	values	value	NOUN
admet-292	759	21	in	in	ADP
admet-292	759	22	the	the	DET
admet-292	759	23	britton	britton	PROPN
admet-292	759	24	-	-	PUNCT
admet-292	759	25	robinson	robinson	PROPN
admet-292	759	26	(	(	PUNCT
admet-292	759	27	br	br	NOUN
admet-292	759	28	)	)	PUNCT
admet-292	759	29	buffer	buffer	NOUN
admet-292	759	30	,	,	PUNCT
admet-292	759	31	using	use	VERB
admet-292	759	32	different	different	ADJ
admet-292	759	33	type	type	NOUN
admet-292	759	34	of	of	ADP
admet-292	759	35	filters	filter	NOUN
admet-292	759	36	(	(	PUNCT
admet-292	759	37	table	table	NOUN
admet-292	759	38	3	3	NUM
admet-292	759	39	)	)	PUNCT
admet-292	759	40	.	.	PUNCT
admet-292	760	1	a	a	DET
admet-292	760	2	further	further	ADJ
admet-292	760	3	aspect	aspect	NOUN
admet-292	760	4	in	in	ADP
admet-292	760	5	the	the	DET
admet-292	760	6	selection	selection	NOUN
admet-292	760	7	of	of	ADP
admet-292	760	8	the	the	DET
admet-292	760	9	filter	filter	NOUN
admet-292	760	10	may	may	AUX
admet-292	760	11	be	be	AUX
admet-292	760	12	its	its	PRON
admet-292	760	13	diameter	diameter	NOUN
admet-292	760	14	and	and	CCONJ
admet-292	760	15	pore	pore	ADJ
admet-292	760	16	size	size	NOUN
admet-292	760	17	.	.	PUNCT
admet-292	761	1	the	the	DET
admet-292	761	2	most	most	ADV
admet-292	761	3	frequently	frequently	ADV
admet-292	761	4	used	use	VERB
admet-292	761	5	ideal	ideal	ADJ
admet-292	761	6	membrane	membrane	NOUN
admet-292	761	7	filter	filter	NOUN
admet-292	761	8	parameters	parameter	NOUN
admet-292	761	9	are	be	AUX
admet-292	761	10	25	25	NUM
admet-292	761	11	mm	mm	NOUN
admet-292	761	12	diameter	diameter	NOUN
admet-292	761	13	and	and	CCONJ
admet-292	761	14	0.22	0.22	NUM
admet-292	761	15	µm	µm	NOUN
admet-292	761	16	or	or	CCONJ
admet-292	761	17	0.45	0.45	NUM
admet-292	761	18	µm	µm	ADP
admet-292	761	19	pore	pore	ADJ
admet-292	761	20	size	size	NOUN
admet-292	761	21	.	.	PUNCT
admet-292	762	1	these	these	DET
admet-292	762	2	pore	pore	ADJ
admet-292	762	3	sizes	size	NOUN
admet-292	762	4	are	be	AUX
admet-292	762	5	suitable	suitable	ADJ
admet-292	762	6	for	for	ADP
admet-292	762	7	macrocrystals	macrocrystal	NOUN
admet-292	762	8	and	and	CCONJ
admet-292	762	9	micronized	micronized	ADJ
admet-292	762	10	particles	particle	NOUN
admet-292	762	11	,	,	PUNCT
admet-292	762	12	however	however	ADV
admet-292	762	13	nano	nano	NOUN
admet-292	762	14	-	-	PUNCT
admet-292	762	15	size	size	NOUN
admet-292	762	16	solids	solid	NOUN
admet-292	762	17	require	require	VERB
admet-292	762	18	specific	specific	ADJ
admet-292	762	19	filters	filter	NOUN
admet-292	762	20	.	.	PUNCT
admet-292	763	1	the	the	DET
admet-292	763	2	solution	solution	NOUN
admet-292	763	3	should	should	AUX
admet-292	763	4	be	be	AUX
admet-292	763	5	slowly	slowly	ADV
admet-292	763	6	filtered	filter	VERB
admet-292	763	7	in	in	ADP
admet-292	763	8	small	small	ADJ
admet-292	763	9	300	300	NUM
admet-292	763	10	-	-	SYM
admet-292	763	11	600	600	NUM
admet-292	763	12	µl	µl	ADP
admet-292	763	13	portions	portion	NOUN
admet-292	763	14	.	.	PUNCT
admet-292	764	1	the	the	DET
admet-292	764	2	first	first	ADJ
admet-292	764	3	1	1	NUM
admet-292	764	4	-	-	SYM
admet-292	764	5	5	5	NUM
admet-292	764	6	aliquots	aliquot	NOUN
admet-292	764	7	saturate	saturate	VERB
admet-292	764	8	the	the	DET
admet-292	764	9	filter	filter	NOUN
admet-292	764	10	,	,	PUNCT
admet-292	764	11	and	and	CCONJ
admet-292	764	12	thus	thus	ADV
admet-292	764	13	need	need	VERB
admet-292	764	14	to	to	PART
admet-292	764	15	be	be	AUX
admet-292	764	16	discarded	discard	VERB
admet-292	764	17	,	,	PUNCT
admet-292	764	18	while	while	SCONJ
admet-292	764	19	the	the	DET
admet-292	764	20	sixth	sixth	ADJ
admet-292	764	21	aliquot	aliquot	NOUN
admet-292	764	22	can	can	AUX
admet-292	764	23	be	be	AUX
admet-292	764	24	used	use	VERB
admet-292	764	25	for	for	ADP
admet-292	764	26	concentration	concentration	NOUN
admet-292	764	27	measurement	measurement	NOUN
admet-292	764	28	.	.	PUNCT
admet-292	765	1	admet	admet	PROPN
admet-292	765	2	&	&	CCONJ
admet-292	765	3	dmpk	dmpk	PROPN
admet-292	765	4	4(2	4(2	NUM
admet-292	765	5	)	)	PUNCT
admet-292	765	6	(	(	PUNCT
admet-292	765	7	2016	2016	NUM
admet-292	765	8	)	)	PUNCT
admet-292	765	9	117	117	NUM
admet-292	765	10	-	-	SYM
admet-292	765	11	178	178	NUM
admet-292	765	12	consensus	consensus	NOUN
admet-292	765	13	recommendations	recommendation	NOUN
admet-292	765	14	for	for	ADP
admet-292	765	15	improving	improve	VERB
admet-292	765	16	solubility	solubility	NOUN
admet-292	765	17	-	-	PUNCT
admet-292	765	18	ph	ph	ADJ
admet-292	765	19	data	datum	NOUN
admet-292	765	20	quality	quality	NOUN
admet-292	765	21	doi	doi	NOUN
admet-292	765	22	:	:	PUNCT
admet-292	765	23	10.5599	10.5599	NUM
admet-292	765	24	/	/	SYM
admet-292	765	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	765	26	153	153	NUM
admet-292	765	27	figure	figure	NOUN
admet-292	765	28	19	19	NUM
admet-292	765	29	.	.	PUNCT
admet-292	766	1	the	the	DET
admet-292	766	2	comparison	comparison	NOUN
admet-292	766	3	of	of	ADP
admet-292	766	4	the	the	DET
admet-292	766	5	intrinsic	intrinsic	ADJ
admet-292	766	6	solubility	solubility	NOUN
admet-292	766	7	values	value	NOUN
admet-292	766	8	of	of	ADP
admet-292	766	9	twelve	twelve	NUM
admet-292	766	10	practically	practically	ADV
admet-292	766	11	-	-	PUNCT
admet-292	766	12	insoluble	insoluble	ADJ
admet-292	766	13	drugs	drug	NOUN
admet-292	766	14	[	[	X
admet-292	766	15	118	118	NUM
admet-292	766	16	]	]	PUNCT
admet-292	766	17	to	to	ADP
admet-292	766	18	the	the	DET
admet-292	766	19	corresponding	corresponding	ADJ
admet-292	766	20	averaged	average	VERB
admet-292	766	21	values	value	NOUN
admet-292	766	22	taken	take	VERB
admet-292	766	23	from	from	ADP
admet-292	766	24	other	other	ADJ
admet-292	766	25	published	publish	VERB
admet-292	766	26	studies	study	NOUN
admet-292	766	27	(	(	PUNCT
admet-292	766	28	with	with	ADP
admet-292	766	29	values	value	NOUN
admet-292	766	30	transformed	transform	VERB
admet-292	766	31	to	to	ADP
admet-292	766	32	25	25	NUM
admet-292	766	33	°	°	NOUN
admet-292	766	34	c	c	NOUN
admet-292	766	35	[	[	X
admet-292	766	36	26	26	NUM
admet-292	766	37	]	]	NUM
admet-292	766	38	)	)	PUNCT
admet-292	766	39	.	.	PUNCT
admet-292	767	1	notably	notably	ADV
admet-292	767	2	,	,	PUNCT
admet-292	767	3	the	the	DET
admet-292	767	4	logs0	logs0	NOUN
admet-292	767	5	values	value	NOUN
admet-292	767	6	along	along	ADP
admet-292	767	7	the	the	DET
admet-292	767	8	horizontal	horizontal	ADJ
admet-292	767	9	axis	axis	NOUN
admet-292	767	10	are	be	AUX
admet-292	767	11	1	1	NUM
admet-292	767	12	-	-	SYM
admet-292	767	13	3	3	NUM
admet-292	767	14	(	(	PUNCT
admet-292	767	15	or	or	CCONJ
admet-292	767	16	more	more	ADJ
admet-292	767	17	)	)	PUNCT
admet-292	767	18	log	log	NOUN
admet-292	767	19	units	unit	NOUN
admet-292	767	20	lower	low	ADJ
admet-292	767	21	than	than	ADP
admet-292	767	22	the	the	DET
admet-292	767	23	average	average	ADJ
admet-292	767	24	values	value	NOUN
admet-292	767	25	reported	report	VERB
admet-292	767	26	from	from	ADP
admet-292	767	27	other	other	ADJ
admet-292	767	28	published	publish	VERB
admet-292	767	29	,	,	PUNCT
admet-292	767	30	with	with	ADP
admet-292	767	31	the	the	DET
admet-292	767	32	exception	exception	NOUN
admet-292	767	33	of	of	ADP
admet-292	767	34	that	that	PRON
admet-292	767	35	of	of	ADP
admet-292	767	36	itraconazole	itraconazole	PROPN
admet-292	767	37	.	.	PUNCT
admet-292	768	1	see	see	VERB
admet-292	768	2	text	text	NOUN
admet-292	768	3	.	.	PUNCT
admet-292	769	1	table	table	NOUN
admet-292	769	2	3	3	NUM
admet-292	769	3	.	.	PUNCT
admet-292	770	1	effect	effect	NOUN
admet-292	770	2	of	of	ADP
admet-292	770	3	separation	separation	NOUN
admet-292	770	4	method	method	NOUN
admet-292	770	5	and	and	CCONJ
admet-292	770	6	filter	filter	NOUN
admet-292	770	7	type	type	NOUN
admet-292	770	8	on	on	ADP
admet-292	770	9	the	the	DET
admet-292	770	10	equilibrium	equilibrium	NOUN
admet-292	770	11	solubility	solubility	NOUN
admet-292	770	12	of	of	ADP
admet-292	770	13	papaverine	papaverine	NOUN
admet-292	770	14	method	method	NOUN
admet-292	770	15	of	of	ADP
admet-292	770	16	separation	separation	NOUN
admet-292	770	17	of	of	ADP
admet-292	770	18	solid	solid	ADJ
admet-292	770	19	from	from	ADP
admet-292	770	20	the	the	DET
admet-292	770	21	saturated	saturate	VERB
admet-292	770	22	solution	solution	NOUN
admet-292	770	23	sph	sph	PROPN
admet-292	770	24	(	(	PUNCT
admet-292	770	25	mg	mg	PROPN
admet-292	770	26	/	/	SYM
admet-292	770	27	ml	ml	NOUN
admet-292	770	28	)	)	PUNCT
admet-292	770	29	ph	ph	NOUN
admet-292	770	30	2.80	2.80	NUM
admet-292	770	31	100	100	NUM
admet-292	770	32	%	%	NOUN
admet-292	770	33	charged	charge	VERB
admet-292	770	34	form	form	NOUN
admet-292	770	35	ph	ph	VERB
admet-292	770	36	6.40	6.40	NUM
admet-292	770	37	50	50	NUM
admet-292	770	38	%	%	NOUN
admet-292	770	39	charged	charge	VERB
admet-292	770	40	50	50	NUM
admet-292	770	41	%	%	NOUN
admet-292	770	42	uncharged	uncharged	ADJ
admet-292	770	43	form	form	NOUN
admet-292	770	44	ph	ph	VERB
admet-292	770	45	9.55	9.55	NUM
admet-292	770	46	100	100	NUM
admet-292	770	47	%	%	NOUN
admet-292	770	48	uncharged	uncharged	ADJ
admet-292	770	49	form	form	NOUN
admet-292	770	50	sedimentation	sedimentation	NOUN
admet-292	770	51	39.1	39.1	NUM
admet-292	770	52	20.4	20.4	NUM
admet-292	770	53	0.017	0.017	NUM
admet-292	770	54	filtration	filtration	NOUN
admet-292	770	55	on	on	ADP
admet-292	770	56	hydrophilic	hydrophilic	ADJ
admet-292	770	57	filter	filter	NOUN
admet-292	770	58	(	(	PUNCT
admet-292	770	59	pvdf	pvdf	PROPN
admet-292	770	60	)	)	PUNCT
admet-292	770	61	36.3	36.3	NUM
admet-292	770	62	22.4	22.4	NUM
admet-292	770	63	0.016	0.016	NUM
admet-292	770	64	filtration	filtration	NOUN
admet-292	770	65	on	on	ADP
admet-292	770	66	hydrophobic	hydrophobic	NOUN
admet-292	770	67	filter	filter	NOUN
admet-292	770	68	(	(	PUNCT
admet-292	770	69	nylon	nylon	NOUN
admet-292	770	70	)	)	PUNCT
admet-292	771	1	36.6	36.6	NUM
admet-292	771	2	9.52	9.52	NUM
admet-292	771	3	0.011	0.011	NUM
admet-292	771	4	alex	alex	PROPN
admet-292	771	5	avdeef	avdeef	PROPN
admet-292	771	6	et	et	PROPN
admet-292	771	7	al	al	PROPN
admet-292	771	8	.	.	PROPN
admet-292	771	9	admet	admet	PROPN
admet-292	771	10	&	&	CCONJ
admet-292	771	11	dmpk	dmpk	PROPN
admet-292	771	12	4(2	4(2	NUM
admet-292	771	13	)	)	PUNCT
admet-292	771	14	(	(	PUNCT
admet-292	771	15	2016	2016	NUM
admet-292	771	16	)	)	PUNCT
admet-292	771	17	117	117	NUM
admet-292	771	18	-	-	SYM
admet-292	771	19	178	178	NUM
admet-292	771	20	154	154	NUM
admet-292	771	21	solubility	solubility	NOUN
admet-292	771	22	units	unit	NOUN
admet-292	771	23	,	,	PUNCT
admet-292	771	24	conversion	conversion	NOUN
admet-292	771	25	issues	issue	NOUN
admet-292	771	26	,	,	PUNCT
admet-292	771	27	tabulation	tabulation	NOUN
admet-292	771	28	of	of	ADP
admet-292	771	29	results	result	NOUN
admet-292	771	30	and	and	CCONJ
admet-292	771	31	the	the	DET
admet-292	771	32	use	use	NOUN
admet-292	771	33	of	of	ADP
admet-292	771	34	logarithmic	logarithmic	ADJ
admet-292	771	35	plots	plot	NOUN
admet-292	771	36	solubility	solubility	NOUN
admet-292	771	37	measurements	measurement	NOUN
admet-292	771	38	have	have	AUX
admet-292	771	39	been	be	AUX
admet-292	771	40	reported	report	VERB
admet-292	771	41	in	in	ADP
admet-292	771	42	many	many	ADJ
admet-292	771	43	different	different	ADJ
admet-292	771	44	concentration	concentration	NOUN
admet-292	771	45	units	unit	NOUN
admet-292	771	46	:	:	PUNCT
admet-292	771	47	weight	weight	NOUN
admet-292	771	48	/	/	SYM
admet-292	771	49	volume	volume	NOUN
admet-292	771	50	(	(	PUNCT
admet-292	771	51	e.g.	e.g.	ADV
admet-292	771	52	,	,	PUNCT
admet-292	771	53	mg	mg	PROPN
admet-292	771	54	/	/	SYM
admet-292	771	55	ml	ml	PROPN
admet-292	771	56	,	,	PUNCT
admet-292	771	57	μg	μg	PROPN
admet-292	771	58	/	/	SYM
admet-292	771	59	ml	ml	PROPN
admet-292	771	60	)	)	PUNCT
admet-292	771	61	,	,	PUNCT
admet-292	771	62	mol	mol	PROPN
admet-292	771	63	/	/	SYM
admet-292	771	64	l	l	NOUN
admet-292	771	65	(	(	PUNCT
admet-292	771	66	molarity	molarity	NOUN
admet-292	771	67	,	,	PUNCT
admet-292	771	68	m	m	PROPN
admet-292	771	69	)	)	PUNCT
admet-292	771	70	,	,	PUNCT
admet-292	771	71	mol	mol	PROPN
admet-292	771	72	/	/	SYM
admet-292	771	73	kg	kg	PROPN
admet-292	771	74	(	(	PUNCT
admet-292	771	75	molality	molality	NOUN
admet-292	771	76	,	,	PUNCT
admet-292	771	77	m	m	PROPN
admet-292	771	78	)	)	PUNCT
admet-292	771	79	,	,	PUNCT
admet-292	771	80	mole	mole	NOUN
admet-292	771	81	fraction	fraction	NOUN
admet-292	771	82	,	,	PUNCT
admet-292	771	83	and	and	CCONJ
admet-292	771	84	mass	mass	ADJ
admet-292	771	85	fraction	fraction	NOUN
admet-292	771	86	–	–	PUNCT
admet-292	771	87	just	just	ADV
admet-292	771	88	to	to	PART
admet-292	771	89	name	name	VERB
admet-292	771	90	a	a	DET
admet-292	771	91	few	few	ADJ
admet-292	771	92	[	[	X
admet-292	771	93	4	4	NUM
admet-292	771	94	]	]	PUNCT
admet-292	771	95	.	.	PUNCT
admet-292	772	1	mole	mole	ADJ
admet-292	772	2	fraction	fraction	NOUN
admet-292	772	3	,	,	PUNCT
admet-292	772	4	mass	mass	NOUN
admet-292	772	5	fraction	fraction	NOUN
admet-292	772	6	,	,	PUNCT
admet-292	772	7	and	and	CCONJ
admet-292	772	8	molality	molality	NOUN
admet-292	772	9	units	unit	NOUN
admet-292	772	10	are	be	AUX
admet-292	772	11	popular	popular	ADJ
admet-292	772	12	choices	choice	NOUN
admet-292	772	13	when	when	SCONJ
admet-292	772	14	solubility	solubility	NOUN
admet-292	772	15	is	be	AUX
admet-292	772	16	determined	determine	VERB
admet-292	772	17	over	over	ADP
admet-292	772	18	a	a	DET
admet-292	772	19	wide	wide	ADJ
admet-292	772	20	range	range	NOUN
admet-292	772	21	of	of	ADP
admet-292	772	22	temperatures	temperature	NOUN
admet-292	772	23	,	,	PUNCT
admet-292	772	24	since	since	SCONJ
admet-292	772	25	the	the	DET
admet-292	772	26	units	unit	NOUN
admet-292	772	27	do	do	AUX
admet-292	772	28	not	not	PART
admet-292	772	29	depend	depend	VERB
admet-292	772	30	on	on	ADP
admet-292	772	31	the	the	DET
admet-292	772	32	density	density	NOUN
admet-292	772	33	of	of	ADP
admet-292	772	34	the	the	DET
admet-292	772	35	solutions	solution	NOUN
admet-292	772	36	in	in	ADP
admet-292	772	37	aqueous	aqueous	ADJ
admet-292	772	38	solutions	solution	NOUN
admet-292	772	39	.	.	PUNCT
admet-292	773	1	also	also	ADV
admet-292	773	2	,	,	PUNCT
admet-292	773	3	such	such	ADJ
admet-292	773	4	units	unit	NOUN
admet-292	773	5	are	be	AUX
admet-292	773	6	convenient	convenient	ADJ
admet-292	773	7	to	to	PART
admet-292	773	8	use	use	VERB
admet-292	773	9	with	with	ADP
admet-292	773	10	viscous	viscous	ADJ
admet-292	773	11	solutions	solution	NOUN
admet-292	773	12	[	[	X
admet-292	773	13	151	151	NUM
admet-292	773	14	]	]	PUNCT
admet-292	773	15	.	.	PUNCT
admet-292	774	1	when	when	SCONJ
admet-292	774	2	solubility	solubility	NOUN
admet-292	774	3	is	be	AUX
admet-292	774	4	reported	report	VERB
admet-292	774	5	in	in	ADP
admet-292	774	6	“	"	PUNCT
admet-292	774	7	practical	practical	ADJ
admet-292	774	8	”	"	PUNCT
admet-292	774	9	mg	mg	PROPN
admet-292	774	10	/	/	SYM
admet-292	774	11	ml	ml	NOUN
admet-292	774	12	or	or	CCONJ
admet-292	774	13	μg	μg	PROPN
admet-292	774	14	/	/	SYM
admet-292	774	15	ml	ml	NOUN
admet-292	774	16	units	unit	NOUN
admet-292	774	17	,	,	PUNCT
admet-292	774	18	the	the	DET
admet-292	774	19	equivalent	equivalent	ADJ
admet-292	774	20	molecular	molecular	ADJ
admet-292	774	21	weight	weight	NOUN
admet-292	774	22	needs	need	VERB
admet-292	774	23	to	to	PART
admet-292	774	24	be	be	AUX
admet-292	774	25	clearly	clearly	ADV
admet-292	774	26	indicated	indicate	VERB
admet-292	774	27	(	(	PUNCT
admet-292	774	28	e.g.	e.g.	ADV
admet-292	774	29	,	,	PUNCT
admet-292	774	30	“	"	PUNCT
admet-292	774	31	concentration	concentration	NOUN
admet-292	774	32	is	be	AUX
admet-292	774	33	expressed	express	VERB
admet-292	774	34	as	as	ADP
admet-292	774	35	free	free	ADJ
admet-292	774	36	base	base	NOUN
admet-292	774	37	equivalents	equivalent	NOUN
admet-292	774	38	,	,	PUNCT
admet-292	774	39	”	"	PUNCT
admet-292	774	40	meaning	mean	VERB
admet-292	774	41	that	that	SCONJ
admet-292	774	42	it	it	PRON
admet-292	774	43	is	be	AUX
admet-292	774	44	the	the	DET
admet-292	774	45	molecular	molecular	ADJ
admet-292	774	46	weight	weight	NOUN
admet-292	774	47	of	of	ADP
admet-292	774	48	the	the	DET
admet-292	774	49	free	free	ADJ
admet-292	774	50	base	base	NOUN
admet-292	774	51	that	that	PRON
admet-292	774	52	is	be	AUX
admet-292	774	53	to	to	PART
admet-292	774	54	be	be	AUX
admet-292	774	55	used	use	VERB
admet-292	774	56	to	to	PART
admet-292	774	57	convert	convert	VERB
admet-292	774	58	practical	practical	ADJ
admet-292	774	59	units	unit	NOUN
admet-292	774	60	to	to	ADP
admet-292	774	61	molarity	molarity	NOUN
admet-292	774	62	units	unit	NOUN
admet-292	774	63	)	)	PUNCT
admet-292	774	64	.	.	PUNCT
admet-292	775	1	as	as	SCONJ
admet-292	775	2	different	different	ADJ
admet-292	775	3	units	unit	NOUN
admet-292	775	4	are	be	AUX
admet-292	775	5	in	in	ADP
admet-292	775	6	common	common	ADJ
admet-292	775	7	usage	usage	NOUN
admet-292	775	8	,	,	PUNCT
admet-292	775	9	it	it	PRON
admet-292	775	10	is	be	AUX
admet-292	775	11	too	too	ADV
admet-292	775	12	easy	easy	ADJ
admet-292	775	13	to	to	PART
admet-292	775	14	make	make	VERB
admet-292	775	15	a	a	DET
admet-292	775	16	mistake	mistake	NOUN
admet-292	775	17	in	in	ADP
admet-292	775	18	converting	convert	VERB
admet-292	775	19	the	the	DET
admet-292	775	20	units	unit	NOUN
admet-292	775	21	to	to	ADP
admet-292	775	22	the	the	DET
admet-292	775	23	common	common	ADJ
admet-292	775	24	molarity	molarity	NOUN
admet-292	775	25	scale	scale	NOUN
admet-292	775	26	.	.	PUNCT
admet-292	776	1	solubility	solubility	NOUN
admet-292	776	2	should	should	AUX
admet-292	776	3	be	be	AUX
admet-292	776	4	presented	present	VERB
admet-292	776	5	in	in	ADP
admet-292	776	6	log	log	NOUN
admet-292	776	7	units	unit	NOUN
admet-292	776	8	(	(	PUNCT
admet-292	776	9	preferably	preferably	ADV
admet-292	776	10	based	base	VERB
admet-292	776	11	on	on	ADP
admet-292	776	12	molarity	molarity	NOUN
admet-292	776	13	)	)	PUNCT
admet-292	776	14	,	,	PUNCT
admet-292	776	15	since	since	SCONJ
admet-292	776	16	(	(	PUNCT
admet-292	776	17	a	a	X
admet-292	776	18	)	)	PUNCT
admet-292	776	19	direct	direct	ADJ
admet-292	776	20	values	value	NOUN
admet-292	776	21	span	span	VERB
admet-292	776	22	over	over	ADP
admet-292	776	23	many	many	ADJ
admet-292	776	24	orders	order	NOUN
admet-292	776	25	of	of	ADP
admet-292	776	26	magnitude	magnitude	NOUN
admet-292	776	27	and	and	CCONJ
admet-292	776	28	can	can	AUX
admet-292	776	29	not	not	PART
admet-292	776	30	be	be	AUX
admet-292	776	31	accurately	accurately	ADV
admet-292	776	32	depicted	depict	VERB
admet-292	776	33	in	in	ADP
admet-292	776	34	s	s	ADJ
admet-292	776	35	-	-	PUNCT
admet-292	776	36	ph	ph	ADJ
admet-292	776	37	plots	plot	NOUN
admet-292	776	38	at	at	ADP
admet-292	776	39	the	the	DET
admet-292	776	40	low	low	ADJ
admet-292	776	41	end	end	NOUN
admet-292	776	42	of	of	ADP
admet-292	776	43	the	the	DET
admet-292	776	44	scale	scale	NOUN
admet-292	776	45	,	,	PUNCT
admet-292	776	46	and	and	CCONJ
admet-292	776	47	(	(	PUNCT
admet-292	776	48	b	b	X
admet-292	776	49	)	)	PUNCT
admet-292	776	50	since	since	SCONJ
admet-292	776	51	errors	error	NOUN
admet-292	776	52	in	in	ADP
admet-292	776	53	log	log	NOUN
admet-292	776	54	values	value	NOUN
admet-292	776	55	do	do	AUX
admet-292	776	56	not	not	PART
admet-292	776	57	depend	depend	VERB
admet-292	776	58	on	on	ADP
admet-292	776	59	the	the	DET
admet-292	776	60	magnitude	magnitude	NOUN
admet-292	776	61	of	of	ADP
admet-292	776	62	the	the	DET
admet-292	776	63	log	log	NOUN
admet-292	776	64	solubility	solubility	NOUN
admet-292	776	65	.	.	PUNCT
admet-292	777	1	when	when	SCONJ
admet-292	777	2	molality	molality	NOUN
admet-292	777	3	units	unit	NOUN
admet-292	777	4	are	be	AUX
admet-292	777	5	used	use	VERB
admet-292	777	6	,	,	PUNCT
admet-292	777	7	it	it	PRON
admet-292	777	8	would	would	AUX
admet-292	777	9	be	be	AUX
admet-292	777	10	useful	useful	ADJ
admet-292	777	11	if	if	SCONJ
admet-292	777	12	the	the	DET
admet-292	777	13	actual	actual	ADJ
admet-292	777	14	solution	solution	NOUN
admet-292	777	15	density	density	NOUN
admet-292	777	16	is	be	AUX
admet-292	777	17	reported	report	VERB
admet-292	777	18	at	at	ADP
admet-292	777	19	the	the	DET
admet-292	777	20	various	various	ADJ
admet-292	777	21	temperatures	temperature	NOUN
admet-292	777	22	studied	study	VERB
admet-292	777	23	.	.	PUNCT
admet-292	778	1	conclusions	conclusion	NOUN
admet-292	778	2	this	this	DET
admet-292	778	3	commentary	commentary	NOUN
admet-292	778	4	drew	draw	VERB
admet-292	778	5	on	on	ADP
admet-292	778	6	the	the	DET
admet-292	778	7	extensive	extensive	ADJ
admet-292	778	8	experimental	experimental	ADJ
admet-292	778	9	knowledge	knowledge	NOUN
admet-292	778	10	and	and	CCONJ
admet-292	778	11	experiences	experience	NOUN
admet-292	778	12	of	of	ADP
admet-292	778	13	several	several	ADJ
admet-292	778	14	laboratories	laboratory	NOUN
admet-292	778	15	with	with	ADP
admet-292	778	16	which	which	PRON
admet-292	778	17	the	the	DET
admet-292	778	18	authors	author	NOUN
admet-292	778	19	are	be	AUX
admet-292	778	20	associated	associate	VERB
admet-292	778	21	.	.	PUNCT
admet-292	779	1	reviewed	review	VERB
admet-292	779	2	were	be	AUX
admet-292	779	3	a	a	DET
admet-292	779	4	number	number	NOUN
admet-292	779	5	of	of	ADP
admet-292	779	6	factors	factor	NOUN
admet-292	779	7	that	that	PRON
admet-292	779	8	can	can	AUX
admet-292	779	9	affect	affect	VERB
admet-292	779	10	the	the	DET
admet-292	779	11	quality	quality	NOUN
admet-292	779	12	of	of	ADP
admet-292	779	13	equilibrium	equilibrium	NOUN
admet-292	779	14	solubility	solubility	NOUN
admet-292	779	15	measurement	measurement	NOUN
admet-292	779	16	as	as	ADP
admet-292	779	17	a	a	DET
admet-292	779	18	function	function	NOUN
admet-292	779	19	of	of	ADP
admet-292	779	20	ph	ph	NOUN
admet-292	779	21	of	of	ADP
admet-292	779	22	druglike	druglike	ADJ
admet-292	779	23	molecules	molecule	NOUN
admet-292	779	24	,	,	PUNCT
admet-292	779	25	especially	especially	ADV
admet-292	779	26	those	those	PRON
admet-292	779	27	which	which	PRON
admet-292	779	28	are	be	AUX
admet-292	779	29	only	only	ADV
admet-292	779	30	sparingly	sparingly	ADV
admet-292	779	31	soluble	soluble	ADJ
admet-292	779	32	.	.	PUNCT
admet-292	780	1	it	it	PRON
admet-292	780	2	was	be	AUX
admet-292	780	3	concluded	conclude	VERB
admet-292	780	4	that	that	SCONJ
admet-292	780	5	the	the	DET
admet-292	780	6	traditional	traditional	ADJ
admet-292	780	7	shake	shake	NOUN
admet-292	780	8	-	-	PUNCT
admet-292	780	9	flask	flask	NOUN
admet-292	780	10	and	and	CCONJ
admet-292	780	11	the	the	DET
admet-292	780	12	potentiometric	potentiometric	ADJ
admet-292	780	13	cheqsol	cheqsol	NOUN
admet-292	780	14	methods	method	NOUN
admet-292	780	15	recommendations	recommendation	NOUN
admet-292	780	16	for	for	ADP
admet-292	780	17	phase	phase	NOUN
admet-292	780	18	separation	separation	NOUN
admet-292	780	19	sedimentation	sedimentation	NOUN
admet-292	780	20	is	be	AUX
admet-292	780	21	recommended	recommend	VERB
admet-292	780	22	as	as	ADP
admet-292	780	23	the	the	DET
admet-292	780	24	safest	safe	ADJ
admet-292	780	25	method	method	NOUN
admet-292	780	26	for	for	ADP
admet-292	780	27	separation	separation	NOUN
admet-292	780	28	of	of	ADP
admet-292	780	29	the	the	DET
admet-292	780	30	solid	solid	ADJ
admet-292	780	31	from	from	ADP
admet-292	780	32	the	the	DET
admet-292	780	33	saturated	saturate	VERB
admet-292	780	34	solution	solution	NOUN
admet-292	780	35	.	.	PUNCT
admet-292	781	1	for	for	ADP
admet-292	781	2	non	non	ADJ
admet-292	781	3	-	-	ADJ
admet-292	781	4	clarifying	clarifying	ADJ
admet-292	781	5	,	,	PUNCT
admet-292	781	6	opalescent	opalescent	NOUN
admet-292	781	7	colloid	colloid	NOUN
admet-292	781	8	solutions	solution	NOUN
admet-292	781	9	the	the	DET
admet-292	781	10	centrifugation	centrifugation	NOUN
admet-292	781	11	can	can	AUX
admet-292	781	12	be	be	AUX
admet-292	781	13	used	use	VERB
admet-292	781	14	.	.	PUNCT
admet-292	782	1	if	if	SCONJ
admet-292	782	2	filtration	filtration	NOUN
admet-292	782	3	can	can	AUX
admet-292	782	4	not	not	PART
admet-292	782	5	be	be	AUX
admet-292	782	6	avoided	avoid	VERB
admet-292	782	7	,	,	PUNCT
admet-292	782	8	then	then	ADV
admet-292	782	9	it	it	PRON
admet-292	782	10	is	be	AUX
admet-292	782	11	essential	essential	ADJ
admet-292	782	12	that	that	SCONJ
admet-292	782	13	the	the	DET
admet-292	782	14	proper	proper	ADJ
admet-292	782	15	filter	filter	NOUN
admet-292	782	16	type	type	NOUN
admet-292	782	17	is	be	AUX
admet-292	782	18	selected	select	VERB
admet-292	782	19	.	.	PUNCT
admet-292	783	1	for	for	ADP
admet-292	783	2	polar	polar	ADJ
admet-292	783	3	,	,	PUNCT
admet-292	783	4	ionized	ionized	ADJ
admet-292	783	5	species	species	NOUN
admet-292	783	6	hydrophobic	hydrophobic	NOUN
admet-292	783	7	(	(	PUNCT
admet-292	783	8	nylon	nylon	NOUN
admet-292	783	9	)	)	PUNCT
admet-292	783	10	is	be	AUX
admet-292	783	11	recommended	recommend	VERB
admet-292	783	12	,	,	PUNCT
admet-292	783	13	while	while	SCONJ
admet-292	783	14	for	for	ADP
admet-292	783	15	unionized	unionized	ADJ
admet-292	783	16	species	specie	NOUN
admet-292	783	17	the	the	DET
admet-292	783	18	hydrophilic	hydrophilic	ADJ
admet-292	783	19	type	type	NOUN
admet-292	783	20	filters	filter	NOUN
admet-292	783	21	(	(	PUNCT
admet-292	783	22	pvdf	pvdf	PROPN
admet-292	783	23	,	,	PUNCT
admet-292	783	24	pes	pes	PROPN
admet-292	783	25	)	)	PUNCT
admet-292	783	26	are	be	AUX
admet-292	783	27	recommended	recommend	VERB
admet-292	783	28	.	.	PUNCT
admet-292	784	1	the	the	DET
admet-292	784	2	filtration	filtration	NOUN
admet-292	784	3	should	should	AUX
admet-292	784	4	be	be	AUX
admet-292	784	5	done	do	VERB
admet-292	784	6	after	after	ADP
admet-292	784	7	sedimentation	sedimentation	NOUN
admet-292	784	8	(	(	PUNCT
admet-292	784	9	resting	rest	VERB
admet-292	784	10	time	time	NOUN
admet-292	784	11	)	)	PUNCT
admet-292	784	12	,	,	PUNCT
admet-292	784	13	and	and	CCONJ
admet-292	784	14	not	not	PART
admet-292	784	15	directly	directly	ADV
admet-292	784	16	after	after	ADP
admet-292	784	17	agitation	agitation	NOUN
admet-292	784	18	.	.	PUNCT
admet-292	785	1	pre	pre	ADJ
admet-292	785	2	-	-	NOUN
admet-292	785	3	saturation	saturation	NOUN
admet-292	785	4	of	of	ADP
admet-292	785	5	the	the	DET
admet-292	785	6	filter	filter	NOUN
admet-292	785	7	is	be	AUX
admet-292	785	8	necessary	necessary	ADJ
admet-292	785	9	.	.	PUNCT
admet-292	786	1	the	the	DET
admet-292	786	2	initial	initial	ADJ
admet-292	786	3	portions	portion	NOUN
admet-292	786	4	of	of	ADP
admet-292	786	5	filtrate	filtrate	NOUN
admet-292	786	6	should	should	AUX
admet-292	786	7	be	be	AUX
admet-292	786	8	discarded	discard	VERB
admet-292	786	9	.	.	PUNCT
admet-292	787	1	recommendation	recommendation	NOUN
admet-292	787	2	for	for	ADP
admet-292	787	3	reporting	report	VERB
admet-292	787	4	solubility	solubility	NOUN
admet-292	787	5	units	unit	NOUN
admet-292	787	6	it	it	PRON
admet-292	787	7	is	be	AUX
admet-292	787	8	recommended	recommend	VERB
admet-292	787	9	that	that	SCONJ
admet-292	787	10	solubility	solubility	NOUN
admet-292	787	11	be	be	AUX
admet-292	787	12	tabulated	tabulate	VERB
admet-292	787	13	both	both	CCONJ
admet-292	787	14	in	in	ADP
admet-292	787	15	molarity	molarity	NOUN
admet-292	787	16	and	and	CCONJ
admet-292	787	17	in	in	ADP
admet-292	787	18	practical	practical	ADJ
admet-292	787	19	(	(	PUNCT
admet-292	787	20	mg	mg	NOUN
admet-292	787	21	/	/	SYM
admet-292	787	22	ml	ml	NOUN
admet-292	787	23	)	)	PUNCT
admet-292	787	24	units	unit	NOUN
admet-292	787	25	,	,	PUNCT
admet-292	787	26	as	as	SCONJ
admet-292	787	27	done	do	VERB
admet-292	787	28	in	in	ADP
admet-292	787	29	the	the	DET
admet-292	787	30	handbook	handbook	NOUN
admet-292	787	31	of	of	ADP
admet-292	787	32	aqueous	aqueous	ADJ
admet-292	787	33	solubility	solubility	NOUN
admet-292	787	34	data	datum	NOUN
admet-292	787	35	(	(	PUNCT
admet-292	787	36	yalkowsky	yalkowsky	PROPN
admet-292	787	37	et	et	PROPN
admet-292	787	38	al	al	PROPN
admet-292	787	39	.	.	PUNCT
admet-292	788	1	[	[	X
admet-292	788	2	152	152	NUM
admet-292	788	3	]	]	SYM
admet-292	788	4	)	)	PUNCT
admet-292	788	5	.	.	PUNCT
admet-292	789	1	standard	standard	ADJ
admet-292	789	2	deviations	deviation	NOUN
admet-292	789	3	in	in	ADP
admet-292	789	4	the	the	DET
admet-292	789	5	measured	measured	ADJ
admet-292	789	6	solubility	solubility	NOUN
admet-292	789	7	(	(	PUNCT
admet-292	789	8	based	base	VERB
admet-292	789	9	on	on	ADP
admet-292	789	10	averaging	average	VERB
admet-292	789	11	three	three	NUM
admet-292	789	12	or	or	CCONJ
admet-292	789	13	more	more	ADJ
admet-292	789	14	values	value	NOUN
admet-292	789	15	)	)	PUNCT
admet-292	789	16	should	should	AUX
admet-292	789	17	be	be	AUX
admet-292	789	18	included	include	VERB
admet-292	789	19	in	in	ADP
admet-292	789	20	the	the	DET
admet-292	789	21	table	table	NOUN
admet-292	789	22	of	of	ADP
admet-292	789	23	values	value	NOUN
admet-292	789	24	.	.	PUNCT
admet-292	790	1	additionally	additionally	ADV
admet-292	790	2	,	,	PUNCT
admet-292	790	3	a	a	DET
admet-292	790	4	graphical	graphical	ADJ
admet-292	790	5	display	display	NOUN
admet-292	790	6	of	of	ADP
admet-292	790	7	logs	log	NOUN
admet-292	790	8	vs.	vs.	X
admet-292	790	9	ph	ph	NOUN
admet-292	790	10	(	(	PUNCT
admet-292	790	11	but	but	CCONJ
admet-292	790	12	not	not	PART
admet-292	790	13	s	s	PROPN
admet-292	790	14	vs.	vs.	X
admet-292	790	15	ph	ph	NOUN
admet-292	790	16	)	)	PUNCT
admet-292	790	17	would	would	AUX
admet-292	790	18	be	be	AUX
admet-292	790	19	helpful	helpful	ADJ
admet-292	790	20	.	.	PUNCT
admet-292	791	1	admet	admet	PROPN
admet-292	791	2	&	&	CCONJ
admet-292	791	3	dmpk	dmpk	PROPN
admet-292	791	4	4(2	4(2	NUM
admet-292	791	5	)	)	PUNCT
admet-292	791	6	(	(	PUNCT
admet-292	791	7	2016	2016	NUM
admet-292	791	8	)	)	PUNCT
admet-292	791	9	117	117	NUM
admet-292	791	10	-	-	SYM
admet-292	791	11	178	178	NUM
admet-292	791	12	consensus	consensus	NOUN
admet-292	791	13	recommendations	recommendation	NOUN
admet-292	791	14	for	for	ADP
admet-292	791	15	improving	improve	VERB
admet-292	791	16	solubility	solubility	NOUN
admet-292	791	17	-	-	PUNCT
admet-292	791	18	ph	ph	ADJ
admet-292	791	19	data	datum	NOUN
admet-292	791	20	quality	quality	NOUN
admet-292	791	21	doi	doi	NOUN
admet-292	791	22	:	:	PUNCT
admet-292	791	23	10.5599	10.5599	NUM
admet-292	791	24	/	/	SYM
admet-292	791	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	791	26	155	155	NUM
admet-292	791	27	could	could	AUX
admet-292	791	28	be	be	AUX
admet-292	791	29	used	use	VERB
admet-292	791	30	,	,	PUNCT
admet-292	791	31	provided	provide	VERB
admet-292	791	32	that	that	SCONJ
admet-292	791	33	proper	proper	ADJ
admet-292	791	34	assay	assay	NOUN
admet-292	791	35	protocol	protocol	NOUN
admet-292	791	36	is	be	AUX
admet-292	791	37	followed	follow	VERB
admet-292	791	38	.	.	PUNCT
admet-292	792	1	it	it	PRON
admet-292	792	2	was	be	AUX
admet-292	792	3	stressed	stress	VERB
admet-292	792	4	that	that	SCONJ
admet-292	792	5	independently	independently	ADV
admet-292	792	6	-	-	PUNCT
admet-292	792	7	determined	determine	VERB
admet-292	792	8	pka	pka	PROPN
admet-292	792	9	values	value	NOUN
admet-292	792	10	of	of	ADP
admet-292	792	11	the	the	DET
admet-292	792	12	drug	drug	NOUN
admet-292	792	13	be	be	AUX
admet-292	792	14	used	use	VERB
admet-292	792	15	in	in	ADP
admet-292	792	16	the	the	DET
admet-292	792	17	analysis	analysis	NOUN
admet-292	792	18	of	of	ADP
admet-292	792	19	the	the	DET
admet-292	792	20	logs	log	NOUN
admet-292	792	21	-	-	PUNCT
admet-292	792	22	ph	ph	ADJ
admet-292	792	23	data	datum	NOUN
admet-292	792	24	.	.	PUNCT
admet-292	793	1	the	the	DET
admet-292	793	2	importance	importance	NOUN
admet-292	793	3	of	of	ADP
admet-292	793	4	solid	solid	ADJ
admet-292	793	5	state	state	NOUN
admet-292	793	6	characterization	characterization	NOUN
admet-292	793	7	was	be	AUX
admet-292	793	8	also	also	ADV
admet-292	793	9	stressed	stress	VERB
admet-292	793	10	,	,	PUNCT
admet-292	793	11	citing	cite	VERB
admet-292	793	12	several	several	ADJ
admet-292	793	13	case	case	NOUN
admet-292	793	14	studies	study	NOUN
admet-292	793	15	of	of	ADP
admet-292	793	16	polymorphic	polymorphic	ADJ
admet-292	793	17	and	and	CCONJ
admet-292	793	18	cocrystal	cocrystal	ADJ
admet-292	793	19	transformations	transformation	NOUN
admet-292	793	20	.	.	PUNCT
admet-292	794	1	the	the	DET
admet-292	794	2	complexity	complexity	NOUN
admet-292	794	3	on	on	ADP
admet-292	794	4	the	the	DET
admet-292	794	5	solution	solution	NOUN
admet-292	794	6	side	side	NOUN
admet-292	794	7	of	of	ADP
admet-292	794	8	solubility	solubility	NOUN
admet-292	794	9	-	-	PUNCT
admet-292	794	10	ph	ph	VERB
admet-292	794	11	measurement	measurement	NOUN
admet-292	794	12	was	be	AUX
admet-292	794	13	illustrated	illustrate	VERB
admet-292	794	14	with	with	ADP
admet-292	794	15	several	several	ADJ
admet-292	794	16	case	case	NOUN
admet-292	794	17	studies	study	NOUN
admet-292	794	18	,	,	PUNCT
admet-292	794	19	where	where	SCONJ
admet-292	794	20	aggregates	aggregate	NOUN
admet-292	794	21	(	(	PUNCT
admet-292	794	22	micellar	micellar	NOUN
admet-292	794	23	and	and	CCONJ
admet-292	794	24	sub	sub	NOUN
admet-292	794	25	-	-	NOUN
admet-292	794	26	micellar	micellar	ADJ
admet-292	794	27	)	)	PUNCT
admet-292	794	28	and	and	CCONJ
admet-292	794	29	drug	drug	NOUN
admet-292	794	30	-	-	PUNCT
admet-292	794	31	buffer	buffer	NOUN
admet-292	794	32	or	or	CCONJ
admet-292	794	33	drug	drug	NOUN
admet-292	794	34	-	-	PUNCT
admet-292	794	35	coformer	coformer	NOUN
admet-292	794	36	complexes	complex	NOUN
admet-292	794	37	appeared	appear	VERB
admet-292	794	38	to	to	PART
admet-292	794	39	form	form	VERB
admet-292	794	40	.	.	PUNCT
admet-292	795	1	the	the	DET
admet-292	795	2	importance	importance	NOUN
admet-292	795	3	of	of	ADP
admet-292	795	4	measuring	measure	VERB
admet-292	795	5	ph	ph	NOUN
admet-292	795	6	accurately	accurately	ADV
admet-292	795	7	in	in	ADP
admet-292	795	8	buffered	buffered	ADJ
admet-292	795	9	and	and	CCONJ
admet-292	795	10	unbuffered	unbuffered	ADJ
admet-292	795	11	solutions	solution	NOUN
admet-292	795	12	was	be	AUX
admet-292	795	13	discussed	discuss	VERB
admet-292	795	14	at	at	ADP
admet-292	795	15	length	length	NOUN
admet-292	795	16	.	.	PUNCT
admet-292	796	1	methods	method	NOUN
admet-292	796	2	and	and	CCONJ
admet-292	796	3	pitfalls	pitfall	NOUN
admet-292	796	4	of	of	ADP
admet-292	796	5	separating	separate	VERB
admet-292	796	6	solid	solid	ADV
admet-292	796	7	from	from	ADP
admet-292	796	8	saturated	saturated	ADJ
admet-292	796	9	solutions	solution	NOUN
admet-292	796	10	were	be	AUX
admet-292	796	11	critically	critically	ADV
admet-292	796	12	discussed	discuss	VERB
admet-292	796	13	.	.	PUNCT
admet-292	797	1	the	the	DET
admet-292	797	2	proper	proper	ADJ
admet-292	797	3	reporting	reporting	NOUN
admet-292	797	4	of	of	ADP
admet-292	797	5	the	the	DET
admet-292	797	6	temperature	temperature	NOUN
admet-292	797	7	,	,	PUNCT
admet-292	797	8	ionic	ionic	ADJ
admet-292	797	9	strength	strength	NOUN
admet-292	797	10	,	,	PUNCT
admet-292	797	11	buffer	buffer	NOUN
admet-292	797	12	capacity	capacity	NOUN
admet-292	797	13	,	,	PUNCT
admet-292	797	14	and	and	CCONJ
admet-292	797	15	other	other	ADJ
admet-292	797	16	experimental	experimental	ADJ
admet-292	797	17	detail	detail	NOUN
admet-292	797	18	was	be	AUX
admet-292	797	19	encouraged	encourage	VERB
admet-292	797	20	.	.	PUNCT
admet-292	798	1	when	when	SCONJ
admet-292	798	2	such	such	ADJ
admet-292	798	3	“	"	PUNCT
admet-292	798	4	good	good	ADJ
admet-292	798	5	practices	practice	NOUN
admet-292	798	6	”	"	PUNCT
admet-292	798	7	could	could	AUX
admet-292	798	8	be	be	AUX
admet-292	798	9	followed	follow	VERB
admet-292	798	10	,	,	PUNCT
admet-292	798	11	it	it	PRON
admet-292	798	12	is	be	AUX
admet-292	798	13	expected	expect	VERB
admet-292	798	14	that	that	SCONJ
admet-292	798	15	high	high	ADJ
admet-292	798	16	quality	quality	NOUN
admet-292	798	17	results	result	NOUN
admet-292	798	18	in	in	ADP
admet-292	798	19	solubility	solubility	NOUN
admet-292	798	20	measurement	measurement	NOUN
admet-292	798	21	could	could	AUX
admet-292	798	22	be	be	AUX
admet-292	798	23	achieved	achieve	VERB
admet-292	798	24	.	.	PUNCT
admet-292	799	1	glossary	glossary	ADJ
admet-292	799	2	api	api	NOUN
admet-292	799	3	active	active	ADJ
admet-292	799	4	pharmaceutical	pharmaceutical	NOUN
admet-292	799	5	ingredient	ingredient	NOUN
admet-292	799	6	bjerrum	bjerrum	NOUN
admet-292	799	7	plot	plot	PROPN
admet-292	799	8	average	average	ADJ
admet-292	799	9	number	number	NOUN
admet-292	799	10	of	of	ADP
admet-292	799	11	ionizable	ionizable	ADJ
admet-292	799	12	protons	proton	NOUN
admet-292	799	13	,	,	PUNCT
admet-292	799	14	n̄h	n̄h	PROPN
admet-292	799	15	,	,	PUNCT
admet-292	799	16	bound	bind	VERB
admet-292	799	17	to	to	ADP
admet-292	799	18	a	a	DET
admet-292	799	19	weak	weak	ADJ
admet-292	799	20	acid	acid	NOUN
admet-292	799	21	/	/	SYM
admet-292	799	22	base	base	NOUN
admet-292	799	23	,	,	PUNCT
admet-292	799	24	plotted	plot	VERB
admet-292	799	25	as	as	ADP
admet-292	799	26	a	a	DET
admet-292	799	27	function	function	NOUN
admet-292	799	28	of	of	ADP
admet-292	799	29	ph	ph	PROPN
admet-292	799	30	.	.	PROPN
admet-292	799	31	for	for	ADP
admet-292	799	32	example	example	NOUN
admet-292	799	33	,	,	PUNCT
admet-292	799	34	for	for	ADP
admet-292	799	35	a	a	DET
admet-292	799	36	monoprotic	monoprotic	ADJ
admet-292	799	37	acidic	acidic	ADJ
admet-292	799	38	drug	drug	NOUN
admet-292	799	39	with	with	ADP
admet-292	799	40	a	a	DET
admet-292	799	41	pka	pka	PROPN
admet-292	799	42	4.5	4.5	NUM
admet-292	799	43	,	,	PUNCT
admet-292	799	44	n̄h	n̄h	PROPN
admet-292	799	45	=	=	NOUN
admet-292	799	46	1.0	1.0	NUM
admet-292	799	47	at	at	ADP
admet-292	799	48	ph	ph	PROPN
admet-292	799	49	2	2	NUM
admet-292	799	50	,	,	PUNCT
admet-292	799	51	n̄h	n̄h	PROPN
admet-292	799	52	=	=	SYM
admet-292	799	53	0.5	0.5	NUM
admet-292	799	54	at	at	ADP
admet-292	799	55	ph	ph	PROPN
admet-292	799	56	4.5	4.5	NUM
admet-292	799	57	,	,	PUNCT
admet-292	799	58	and	and	CCONJ
admet-292	799	59	n̄h	n̄h	ADV
admet-292	799	60	=	=	SYM
admet-292	799	61	0.0	0.0	NUM
admet-292	799	62	at	at	ADP
admet-292	799	63	ph	ph	PROPN
admet-292	799	64	9	9	NUM
admet-292	799	65	[	[	SYM
admet-292	799	66	27	27	NUM
admet-292	799	67	,	,	PUNCT
admet-292	799	68	153	153	NUM
admet-292	799	69	]	]	PUNCT
admet-292	799	70	.	.	PUNCT
admet-292	800	1	br	br	PROPN
admet-292	800	2	britton	britton	PROPN
admet-292	800	3	-	-	PUNCT
admet-292	800	4	robinson	robinson	PROPN
admet-292	800	5	buffer	buffer	NOUN
admet-292	800	6	[	[	X
admet-292	800	7	154	154	NUM
admet-292	800	8	]	]	PUNCT
admet-292	800	9	ccdc	ccdc	PROPN
admet-292	800	10	cambridge	cambridge	PROPN
admet-292	800	11	crystallographic	crystallographic	PROPN
admet-292	800	12	data	data	PROPN
admet-292	800	13	centre	centre	PROPN
admet-292	800	14	cheqsol	cheqsol	ADV
admet-292	800	15	chasing	chase	VERB
admet-292	800	16	equilibrium	equilibrium	NOUN
admet-292	800	17	solubility	solubility	NOUN
admet-292	800	18	cmc	cmc	NOUN
admet-292	800	19	critical	critical	ADJ
admet-292	800	20	micelle	micelle	NOUN
admet-292	800	21	concentration	concentration	NOUN
admet-292	800	22	csc	csc	PROPN
admet-292	800	23	critical	critical	ADJ
admet-292	800	24	stabilization	stabilization	NOUN
admet-292	800	25	concentration	concentration	NOUN
admet-292	800	26	csd	csd	PROPN
admet-292	800	27	cambridge	cambridge	PROPN
admet-292	800	28	structural	structural	PROPN
admet-292	800	29	database	database	PROPN
admet-292	800	30	cv	cv	PROPN
admet-292	800	31	coefficient	coefficient	NOUN
admet-292	800	32	of	of	ADP
admet-292	800	33	variation	variation	NOUN
admet-292	800	34	dtt	dtt	X
admet-292	800	35	dissolution	dissolution	NOUN
admet-292	800	36	titration	titration	NOUN
admet-292	800	37	template	template	NOUN
admet-292	800	38	(	(	PUNCT
admet-292	800	39	potentiometric	potentiometric	ADJ
admet-292	800	40	method	method	NOUN
admet-292	800	41	to	to	PART
admet-292	800	42	determine	determine	VERB
admet-292	800	43	intrinsic	intrinsic	ADJ
admet-292	800	44	solubility	solubility	NOUN
admet-292	800	45	,	,	PUNCT
admet-292	800	46	s0	s0	PROPN
admet-292	800	47	)	)	PUNCT
admet-292	800	48	dsc	dsc	NOUN
admet-292	800	49	differential	differential	NOUN
admet-292	800	50	scanning	scan	VERB
admet-292	800	51	calorimetry	calorimetry	NOUN
admet-292	800	52	dash	dash	NOUN
admet-292	800	53	interactive	interactive	ADJ
admet-292	800	54	package	package	NOUN
admet-292	800	55	from	from	ADP
admet-292	800	56	the	the	DET
admet-292	800	57	cambridge	cambridge	PROPN
admet-292	800	58	crystallographic	crystallographic	PROPN
admet-292	800	59	data	data	PROPN
admet-292	800	60	centre	centre	PROPN
admet-292	800	61	(	(	PUNCT
admet-292	800	62	ccdc	ccdc	PROPN
admet-292	800	63	)	)	PUNCT
admet-292	800	64	for	for	ADP
admet-292	800	65	solving	solve	VERB
admet-292	800	66	crystal	crystal	NOUN
admet-292	800	67	structures	structure	NOUN
admet-292	800	68	from	from	ADP
admet-292	800	69	powder	powder	NOUN
admet-292	800	70	diffraction	diffraction	NOUN
admet-292	800	71	data	datum	NOUN
admet-292	800	72	(	(	PUNCT
admet-292	800	73	https://www.ccdc.cam.ac.uk/solutions/csdmaterials/components/dash/	https://www.ccdc.cam.ac.uk/solutions/csdmaterials/components/dash/	NOUN
admet-292	800	74	)	)	PUNCT
admet-292	800	75	gsas	gsas	PROPN
admet-292	800	76	general	general	ADJ
admet-292	800	77	structure	structure	NOUN
admet-292	800	78	analysis	analysis	NOUN
admet-292	800	79	system	system	NOUN
admet-292	800	80	.	.	PUNCT
admet-292	801	1	comprehensive	comprehensive	ADJ
admet-292	801	2	system	system	NOUN
admet-292	801	3	created	create	VERB
admet-292	801	4	by	by	ADP
admet-292	801	5	allen	allen	PROPN
admet-292	801	6	c.	c.	PROPN
admet-292	801	7	larson	larson	PROPN
admet-292	801	8	and	and	CCONJ
admet-292	801	9	robert	robert	PROPN
admet-292	801	10	b.	b.	PROPN
admet-292	801	11	von	von	PROPN
admet-292	801	12	dreele	dreele	PROPN
admet-292	801	13	of	of	ADP
admet-292	801	14	los	los	PROPN
admet-292	801	15	alamos	alamos	PROPN
admet-292	801	16	national	national	PROPN
admet-292	801	17	laboratory	laboratory	PROPN
admet-292	801	18	for	for	ADP
admet-292	801	19	the	the	DET
admet-292	801	20	refinement	refinement	NOUN
admet-292	801	21	of	of	ADP
admet-292	801	22	structural	structural	ADJ
admet-292	801	23	models	model	NOUN
admet-292	801	24	(	(	PUNCT
admet-292	801	25	http://www.ncnr.nist.gov/xtal/software/downloads.html	http://www.ncnr.nist.gov/xtal/software/downloads.html	NOUN
admet-292	801	26	)	)	PUNCT
admet-292	801	27	,	,	PUNCT
admet-292	801	28	for	for	ADP
admet-292	801	29	both	both	DET
admet-292	801	30	x	x	NOUN
admet-292	801	31	-	-	NOUN
admet-292	801	32	ray	ray	NOUN
admet-292	801	33	and	and	CCONJ
admet-292	801	34	neutron	neutron	NOUN
admet-292	801	35	diffraction	diffraction	NOUN
admet-292	801	36	data	datum	NOUN
admet-292	801	37	hh	hh	PROPN
admet-292	801	38	henderson	henderson	PROPN
admet-292	801	39	-	-	PUNCT
admet-292	801	40	hasselbalch	hasselbalch	PROPN
admet-292	801	41	equation	equation	NOUN
admet-292	801	42	(	(	PUNCT
admet-292	801	43	e.g.	e.g.	ADV
admet-292	801	44	,	,	PUNCT
admet-292	801	45	eq	eq	NOUN
admet-292	801	46	.	.	NOUN
admet-292	801	47	1	1	NUM
admet-292	801	48	)	)	PUNCT
admet-292	801	49	i	i	PRON
admet-292	801	50	ionic	ionic	ADJ
admet-292	801	51	strength	strength	NOUN
admet-292	801	52	of	of	ADP
admet-292	801	53	the	the	DET
admet-292	801	54	solution	solution	NOUN
admet-292	801	55	ir	ir	PROPN
admet-292	801	56	infrared	infrared	PROPN
admet-292	801	57	spectroscopy	spectroscopy	VERB
admet-292	801	58	kn	kn	PROPN
admet-292	801	59	aggregation	aggregation	NOUN
admet-292	801	60	constant	constant	ADJ
admet-292	801	61	,	,	PUNCT
admet-292	801	62	where	where	SCONJ
admet-292	801	63	n	n	PRON
admet-292	801	64	is	be	AUX
admet-292	801	65	the	the	DET
admet-292	801	66	degree	degree	NOUN
admet-292	801	67	of	of	ADP
admet-292	801	68	aggregation	aggregation	NOUN
admet-292	801	69	ksp	ksp	PROPN
admet-292	801	70	drug	drug	NOUN
admet-292	801	71	-	-	PUNCT
admet-292	801	72	salt	salt	NOUN
admet-292	801	73	or	or	CCONJ
admet-292	801	74	drug	drug	NOUN
admet-292	801	75	-	-	PUNCT
admet-292	801	76	coformer	coformer	NOUN
admet-292	801	77	(	(	PUNCT
admet-292	801	78	cocrystal	cocrystal	ADJ
admet-292	801	79	)	)	PUNCT
admet-292	801	80	solubility	solubility	NOUN
admet-292	801	81	product	product	NOUN
admet-292	801	82	ljp	ljp	NOUN
admet-292	801	83	liquid	liquid	ADJ
admet-292	801	84	junction	junction	NOUN
admet-292	801	85	potential	potential	NOUN
admet-292	801	86	llps	llp	NOUN
admet-292	801	87	liquid	liquid	NOUN
admet-292	801	88	-	-	PUNCT
admet-292	801	89	liquid	liquid	NOUN
admet-292	801	90	phase	phase	NOUN
admet-292	801	91	separation	separation	NOUN
admet-292	801	92	mub	mub	NOUN
admet-292	801	93	minimalist	minimalist	ADJ
admet-292	801	94	universal	universal	ADJ
admet-292	801	95	buffer	buffer	NOUN
admet-292	801	96	msz	msz	VERB
admet-292	801	97	metastable	metastable	ADJ
admet-292	801	98	zone	zone	NOUN
admet-292	801	99	https://www.ccdc.cam.ac.uk/solutions/csd-materials/components/dash/	https://www.ccdc.cam.ac.uk/solutions/csd-materials/components/dash/	NOUN
admet-292	801	100	https://www.ccdc.cam.ac.uk/solutions/csd-materials/components/dash/	https://www.ccdc.cam.ac.uk/solutions/csd-materials/components/dash/	NOUN
admet-292	801	101	http://www.ncnr.nist.gov/xtal/software/downloads.html	http://www.ncnr.nist.gov/xtal/software/downloads.html	X
admet-292	801	102	alex	alex	PROPN
admet-292	801	103	avdeef	avdeef	PROPN
admet-292	801	104	et	et	PROPN
admet-292	801	105	al	al	PROPN
admet-292	801	106	.	.	PROPN
admet-292	801	107	admet	admet	PROPN
admet-292	801	108	&	&	CCONJ
admet-292	801	109	dmpk	dmpk	PROPN
admet-292	801	110	4(2	4(2	NUM
admet-292	801	111	)	)	PUNCT
admet-292	801	112	(	(	PUNCT
admet-292	801	113	2016	2016	NUM
admet-292	801	114	)	)	PUNCT
admet-292	801	115	117	117	NUM
admet-292	801	116	-	-	SYM
admet-292	801	117	178	178	NUM
admet-292	801	118	156	156	NUM
admet-292	802	1	[	[	X
admet-292	802	2	pc	pc	X
admet-292	802	3	]	]	SYM
admet-292	802	4	2	2	NUM
admet-292	802	5	potentiometric	potentiometric	NOUN
admet-292	802	6	cycling	cycling	NOUN
admet-292	802	7	for	for	ADP
admet-292	802	8	polymorph	polymorph	NOUN
admet-292	802	9	creation	creation	NOUN
admet-292	802	10	pka	pka	PROPN
admet-292	802	11	negative	negative	ADJ
admet-292	802	12	logarithm	logarithm	NOUN
admet-292	802	13	of	of	ADP
admet-292	802	14	the	the	DET
admet-292	802	15	ionization	ionization	NOUN
admet-292	802	16	constant	constant	ADJ
admet-292	802	17	pka	pka	PROPN
admet-292	802	18	gibbs	gibbs	PROPN
admet-292	802	19	ph	ph	PROPN
admet-292	802	20	where	where	SCONJ
admet-292	802	21	the	the	DET
admet-292	802	22	drug	drug	NOUN
admet-292	802	23	in	in	ADP
admet-292	802	24	the	the	DET
admet-292	802	25	uncharged	uncharged	ADJ
admet-292	802	26	form	form	NOUN
admet-292	802	27	co	co	NOUN
admet-292	802	28	-	-	NOUN
admet-292	802	29	precipitates	precipitate	NOUN
admet-292	802	30	with	with	ADP
admet-292	802	31	the	the	DET
admet-292	802	32	drug	drug	NOUN
admet-292	802	33	in	in	ADP
admet-292	802	34	the	the	DET
admet-292	802	35	salt	salt	NOUN
admet-292	802	36	form	form	NOUN
admet-292	802	37	phsat	phsat	VERB
admet-292	802	38	equilibrium	equilibrium	NOUN
admet-292	802	39	ph	ph	NOUN
admet-292	802	40	of	of	ADP
admet-292	802	41	a	a	DET
admet-292	802	42	saturated	saturate	VERB
admet-292	802	43	solution	solution	NOUN
admet-292	802	44	pxrd	pxrd	NOUN
admet-292	802	45	powder	powder	NOUN
admet-292	802	46	x	x	NOUN
admet-292	802	47	-	-	NOUN
admet-292	802	48	ray	ray	NOUN
admet-292	802	49	diffraction	diffraction	NOUN
admet-292	802	50	characterization	characterization	NOUN
admet-292	802	51	of	of	ADP
admet-292	802	52	the	the	DET
admet-292	802	53	solid	solid	ADJ
admet-292	802	54	form	form	NOUN
admet-292	802	55	s	s	PART
admet-292	802	56	solubility	solubility	NOUN
admet-292	802	57	,	,	PUNCT
admet-292	802	58	ideally	ideally	ADV
admet-292	802	59	expressed	express	VERB
admet-292	802	60	in	in	ADP
admet-292	802	61	units	unit	NOUN
admet-292	802	62	of	of	ADP
admet-292	802	63	mol	mol	PROPN
admet-292	802	64	/	/	SYM
admet-292	802	65	l	l	NOUN
admet-292	802	66	(	(	PUNCT
admet-292	802	67	m	m	PROPN
admet-292	802	68	)	)	PUNCT
admet-292	802	69	,	,	PUNCT
admet-292	802	70	μg	μg	PROPN
admet-292	802	71	/	/	SYM
admet-292	802	72	ml	ml	PROPN
admet-292	802	73	,	,	PUNCT
admet-292	802	74	or	or	CCONJ
admet-292	802	75	mg	mg	PROPN
admet-292	802	76	/	/	SYM
admet-292	802	77	ml	ml	NOUN
admet-292	802	78	s0	s0	NOUN
admet-292	802	79	“	"	PUNCT
admet-292	802	80	intrinsic	intrinsic	ADJ
admet-292	802	81	”	"	PUNCT
admet-292	802	82	solubility	solubility	NOUN
admet-292	802	83	(	(	PUNCT
admet-292	802	84	i.e.	i.e.	X
admet-292	802	85	,	,	PUNCT
admet-292	802	86	the	the	DET
admet-292	802	87	solubility	solubility	NOUN
admet-292	802	88	of	of	ADP
admet-292	802	89	the	the	DET
admet-292	802	90	uncharged	uncharged	ADJ
admet-292	802	91	form	form	NOUN
admet-292	802	92	of	of	ADP
admet-292	802	93	the	the	DET
admet-292	802	94	compound	compound	NOUN
admet-292	802	95	)	)	PUNCT
admet-292	802	96	sw	sw	PROPN
admet-292	802	97	“	"	PUNCT
admet-292	802	98	water	water	NOUN
admet-292	802	99	”	"	PUNCT
admet-292	802	100	solubility	solubility	NOUN
admet-292	802	101	,	,	PUNCT
admet-292	802	102	defined	define	VERB
admet-292	802	103	by	by	ADP
admet-292	802	104	dissolving	dissolve	VERB
admet-292	802	105	enough	enough	ADJ
admet-292	802	106	pure	pure	ADJ
admet-292	802	107	free	free	ADJ
admet-292	802	108	acid	acid	NOUN
admet-292	802	109	/	/	SYM
admet-292	802	110	base	base	NOUN
admet-292	802	111	in	in	ADP
admet-292	802	112	distilled	distil	VERB
admet-292	802	113	water	water	NOUN
admet-292	802	114	(	(	PUNCT
admet-292	802	115	or	or	CCONJ
admet-292	802	116	water	water	NOUN
admet-292	802	117	containing	contain	VERB
admet-292	802	118	an	an	DET
admet-292	802	119	inert	inert	ADJ
admet-292	802	120	salt	salt	NOUN
admet-292	802	121	–	–	PUNCT
admet-292	802	122	as	as	ADP
admet-292	802	123	ionic	ionic	ADJ
admet-292	802	124	strength	strength	NOUN
admet-292	802	125	adjustor	adjustor	NOUN
admet-292	802	126	)	)	PUNCT
admet-292	802	127	to	to	PART
admet-292	802	128	form	form	VERB
admet-292	802	129	a	a	DET
admet-292	802	130	saturated	saturate	VERB
admet-292	802	131	solution	solution	NOUN
admet-292	802	132	.	.	PUNCT
admet-292	803	1	the	the	DET
admet-292	803	2	final	final	ADJ
admet-292	803	3	ph	ph	NOUN
admet-292	803	4	of	of	ADP
admet-292	803	5	the	the	DET
admet-292	803	6	suspension	suspension	NOUN
admet-292	803	7	,	,	PUNCT
admet-292	803	8	phsat	phsat	NOUN
admet-292	803	9	,	,	PUNCT
admet-292	803	10	and	and	CCONJ
admet-292	803	11	s0	s0	PROPN
admet-292	803	12	can	can	AUX
admet-292	803	13	be	be	AUX
admet-292	803	14	calculated	calculate	VERB
admet-292	803	15	by	by	ADP
admet-292	803	16	the	the	DET
admet-292	803	17	hh	hh	PROPN
admet-292	803	18	equation	equation	NOUN
admet-292	803	19	(	(	PUNCT
admet-292	803	20	when	when	SCONJ
admet-292	803	21	valid	valid	ADJ
admet-292	803	22	)	)	PUNCT
admet-292	803	23	,	,	PUNCT
admet-292	803	24	provided	provide	VERB
admet-292	803	25	the	the	DET
admet-292	803	26	true	true	ADJ
admet-292	803	27	pka	pka	PROPN
admet-292	803	28	is	be	AUX
admet-292	803	29	known	know	VERB
admet-292	803	30	.	.	PUNCT
admet-292	804	1	compound	compound	NOUN
admet-292	804	2	added	add	VERB
admet-292	804	3	as	as	ADP
admet-292	804	4	a	a	DET
admet-292	804	5	salt	salt	NOUN
admet-292	804	6	form	form	NOUN
admet-292	804	7	may	may	AUX
admet-292	804	8	disproportionate	disproportionate	VERB
admet-292	804	9	into	into	ADP
admet-292	804	10	free	free	ADJ
admet-292	804	11	acid	acid	NOUN
admet-292	804	12	/	/	SYM
admet-292	804	13	base	base	NOUN
admet-292	804	14	,	,	PUNCT
admet-292	804	15	depending	depend	VERB
admet-292	804	16	on	on	ADP
admet-292	804	17	how	how	SCONJ
admet-292	804	18	much	much	ADJ
admet-292	804	19	solid	solid	ADJ
admet-292	804	20	had	have	AUX
admet-292	804	21	been	be	AUX
admet-292	804	22	added	add	VERB
admet-292	804	23	.	.	PUNCT
admet-292	805	1	it	it	PRON
admet-292	805	2	is	be	AUX
admet-292	805	3	not	not	PART
admet-292	805	4	generally	generally	ADV
admet-292	805	5	possible	possible	ADJ
admet-292	805	6	to	to	PART
admet-292	805	7	calculate	calculate	VERB
admet-292	805	8	the	the	DET
admet-292	805	9	ph	ph	NOUN
admet-292	805	10	and	and	CCONJ
admet-292	805	11	s0	s0	PROPN
admet-292	805	12	of	of	ADP
admet-292	805	13	such	such	DET
admet-292	805	14	a	a	DET
admet-292	805	15	drug	drug	NOUN
admet-292	805	16	salt	salt	NOUN
admet-292	805	17	suspension	suspension	NOUN
admet-292	805	18	.	.	PUNCT
admet-292	806	1	sph	sph	NOUN
admet-292	806	2	“	"	PUNCT
admet-292	806	3	ph	ph	ADJ
admet-292	806	4	buffer	buffer	NOUN
admet-292	806	5	”	"	PUNCT
admet-292	806	6	solubility	solubility	NOUN
admet-292	806	7	(	(	PUNCT
admet-292	806	8	i.e.	i.e.	X
admet-292	806	9	,	,	PUNCT
admet-292	806	10	the	the	DET
admet-292	806	11	total	total	ADJ
admet-292	806	12	solubility	solubility	NOUN
admet-292	806	13	of	of	ADP
admet-292	806	14	the	the	DET
admet-292	806	15	compound	compound	NOUN
admet-292	806	16	at	at	ADP
admet-292	806	17	a	a	DET
admet-292	806	18	well	well	ADV
admet-292	806	19	-	-	PUNCT
admet-292	806	20	defined	define	VERB
admet-292	806	21	phsat	phsat	NOUN
admet-292	806	22	)	)	PUNCT
admet-292	806	23	tga	tga	PROPN
admet-292	806	24	thermogravimetric	thermogravimetric	ADJ
admet-292	806	25	analysis	analysis	NOUN
admet-292	806	26	acknowledgements	acknowledgement	NOUN
admet-292	806	27	:	:	PUNCT
admet-292	806	28	t.v	t.v	X
admet-292	806	29	.	.	PROPN
admet-292	806	30	wishes	wish	VERB
admet-292	806	31	to	to	PART
admet-292	806	32	thank	thank	VERB
admet-292	806	33	drs	dr	NOUN
admet-292	806	34	.	.	PUNCT
admet-292	807	1	gordana	gordana	NOUN
admet-292	807	2	popović	popović	NOUN
admet-292	807	3	and	and	CCONJ
admet-292	807	4	lidija	lidija	NOUN
admet-292	807	5	pfendt	pfendt	NOUN
admet-292	807	6	for	for	ADP
admet-292	807	7	many	many	ADJ
admet-292	807	8	helpful	helpful	ADJ
admet-292	807	9	discussions	discussion	NOUN
admet-292	807	10	.	.	PUNCT
admet-292	808	1	a.a	a.a	PROPN
admet-292	808	2	.	.	PROPN
admet-292	808	3	wishes	wish	VERB
admet-292	808	4	to	to	PART
admet-292	808	5	thank	thank	VERB
admet-292	808	6	drs	dr	NOUN
admet-292	808	7	.	.	PUNCT
admet-292	809	1	agustin	agustin	PROPN
admet-292	809	2	asuero	asuero	PROPN
admet-292	809	3	(	(	PUNCT
admet-292	809	4	seville	seville	PROPN
admet-292	809	5	univ	univ	PROPN
admet-292	809	6	.	.	PUNCT
admet-292	809	7	)	)	PUNCT
admet-292	809	8	,	,	PUNCT
admet-292	809	9	michael	michael	PROPN
admet-292	809	10	abraham	abraham	PROPN
admet-292	809	11	(	(	PUNCT
admet-292	809	12	univ	univ	PROPN
admet-292	809	13	.	.	PUNCT
admet-292	809	14	college	college	PROPN
admet-292	809	15	london	london	PROPN
admet-292	809	16	)	)	PUNCT
admet-292	809	17	,	,	PUNCT
admet-292	809	18	and	and	CCONJ
admet-292	809	19	lennart	lennart	PROPN
admet-292	809	20	lindfors	lindfor	NOUN
admet-292	809	21	of	of	ADP
admet-292	809	22	astrazeneca	astrazeneca	PROPN
admet-292	809	23	(	(	PUNCT
admet-292	809	24	mölndal	mölndal	NOUN
admet-292	809	25	)	)	PUNCT
admet-292	809	26	for	for	ADP
admet-292	809	27	stimulating	stimulate	VERB
admet-292	809	28	discussions	discussion	NOUN
admet-292	809	29	.	.	PUNCT
admet-292	810	1	admet	admet	PROPN
admet-292	810	2	&	&	CCONJ
admet-292	810	3	dmpk	dmpk	PROPN
admet-292	810	4	4(2	4(2	NUM
admet-292	810	5	)	)	PUNCT
admet-292	810	6	(	(	PUNCT
admet-292	810	7	2016	2016	NUM
admet-292	810	8	)	)	PUNCT
admet-292	810	9	117	117	NUM
admet-292	810	10	-	-	SYM
admet-292	810	11	178	178	NUM
admet-292	810	12	consensus	consensus	NOUN
admet-292	810	13	recommendations	recommendation	NOUN
admet-292	810	14	for	for	ADP
admet-292	810	15	improving	improve	VERB
admet-292	810	16	solubility	solubility	NOUN
admet-292	810	17	-	-	PUNCT
admet-292	810	18	ph	ph	ADJ
admet-292	810	19	data	datum	NOUN
admet-292	810	20	quality	quality	NOUN
admet-292	810	21	doi	doi	NOUN
admet-292	810	22	:	:	PUNCT
admet-292	810	23	10.5599	10.5599	NUM
admet-292	810	24	/	/	SYM
admet-292	810	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	810	26	157	157	NUM
admet-292	810	27	references	reference	NOUN
admet-292	810	28	[	[	X
admet-292	810	29	1	1	NUM
admet-292	810	30	]	]	PUNCT
admet-292	810	31	a.	a.	NOUN
admet-292	810	32	llinàs	llinàs	PROPN
admet-292	810	33	,	,	PUNCT
admet-292	810	34	r.c	r.c	PROPN
admet-292	810	35	.	.	PROPN
admet-292	810	36	glen	glen	PROPN
admet-292	810	37	,	,	PUNCT
admet-292	810	38	j.m	j.m	PROPN
admet-292	810	39	.	.	PROPN
admet-292	810	40	goodman	goodman	PROPN
admet-292	810	41	.	.	PUNCT
admet-292	811	1	j.	j.	PROPN
admet-292	811	2	chem	chem	PROPN
admet-292	811	3	.	.	PUNCT
admet-292	812	1	inf	inf	PROPN
admet-292	812	2	.	.	PROPN
admet-292	812	3	model	model	PROPN
admet-292	812	4	.	.	PUNCT
admet-292	813	1	48	48	NUM
admet-292	813	2	(	(	PUNCT
admet-292	813	3	2008	2008	NUM
admet-292	813	4	)	)	PUNCT
admet-292	813	5	1289–1303	1289–1303	NUM
admet-292	813	6	.	.	PUNCT
admet-292	814	1	[	[	X
admet-292	814	2	2	2	NUM
admet-292	814	3	]	]	X
admet-292	814	4	a.j	a.j	PROPN
admet-292	814	5	.	.	PROPN
admet-292	814	6	hopfinger	hopfinger	PROPN
admet-292	814	7	,	,	PUNCT
admet-292	814	8	e.x	e.x	PROPN
admet-292	814	9	.	.	PROPN
admet-292	814	10	esposito	esposito	PROPN
admet-292	814	11	,	,	PUNCT
admet-292	814	12	a.	a.	PROPN
admet-292	814	13	llinàs	llinàs	PROPN
admet-292	814	14	,	,	PUNCT
admet-292	814	15	r.c	r.c	PROPN
admet-292	814	16	.	.	PROPN
admet-292	814	17	glen	glen	PROPN
admet-292	814	18	,	,	PUNCT
admet-292	814	19	j.m	j.m	PROPN
admet-292	814	20	.	.	PROPN
admet-292	814	21	goodman	goodman	PROPN
admet-292	814	22	.	.	PUNCT
admet-292	815	1	j.	j.	PROPN
admet-292	815	2	chem	chem	PROPN
admet-292	815	3	.	.	PUNCT
admet-292	816	1	inf	inf	PROPN
admet-292	816	2	.	.	PROPN
admet-292	816	3	model	model	PROPN
admet-292	816	4	.	.	PUNCT
admet-292	817	1	49	49	NUM
admet-292	817	2	(	(	PUNCT
admet-292	817	3	2009	2009	NUM
admet-292	817	4	)	)	PUNCT
admet-292	817	5	1	1	NUM
admet-292	817	6	-	-	SYM
admet-292	817	7	5	5	NUM
admet-292	817	8	.	.	PUNCT
admet-292	818	1	[	[	X
admet-292	818	2	3	3	X
admet-292	818	3	]	]	X
admet-292	818	4	e.	e.	PROPN
admet-292	818	5	baka	baka	PROPN
admet-292	818	6	,	,	PUNCT
admet-292	818	7	j.	j.	PROPN
admet-292	818	8	e.a	e.a	PROPN
admet-292	818	9	.	.	PROPN
admet-292	818	10	comer	comer	PROPN
admet-292	818	11	,	,	PUNCT
admet-292	818	12	k.	k.	PROPN
admet-292	818	13	takács	takács	PROPN
admet-292	818	14	-	-	PUNCT
admet-292	818	15	novák	novák	PROPN
admet-292	818	16	.	.	PUNCT
admet-292	819	1	j.	j.	PROPN
admet-292	819	2	pharm	pharm	PROPN
admet-292	819	3	.	.	PUNCT
admet-292	819	4	biomed	biome	VERB
admet-292	819	5	.	.	PUNCT
admet-292	820	1	anal	anal	ADJ
admet-292	820	2	.	.	PUNCT
admet-292	821	1	46	46	NUM
admet-292	821	2	(	(	PUNCT
admet-292	821	3	2008	2008	NUM
admet-292	821	4	)	)	PUNCT
admet-292	822	1	335–341	335–341	NUM
admet-292	822	2	.	.	PUNCT
admet-292	823	1	[	[	X
admet-292	823	2	4	4	NUM
admet-292	823	3	]	]	PUNCT
admet-292	823	4	a.	a.	NOUN
admet-292	823	5	avdeef	avdeef	PROPN
admet-292	823	6	.	.	PUNCT
admet-292	824	1	admet	admet	PROPN
admet-292	824	2	&	&	CCONJ
admet-292	824	3	dmpk	dmpk	PROPN
admet-292	824	4	3	3	NUM
admet-292	824	5	(	(	PUNCT
admet-292	824	6	2015	2015	NUM
admet-292	824	7	)	)	PUNCT
admet-292	824	8	84	84	NUM
admet-292	824	9	-	-	SYM
admet-292	824	10	109	109	NUM
admet-292	824	11	.	.	PUNCT
admet-292	825	1	[	[	X
admet-292	825	2	5	5	NUM
admet-292	825	3	]	]	X
admet-292	825	4	n.k	n.k	PROPN
admet-292	825	5	.	.	PROPN
admet-292	825	6	pandit	pandit	PROPN
admet-292	825	7	,	,	PUNCT
admet-292	825	8	j.m	j.m	PROPN
admet-292	825	9	.	.	PROPN
admet-292	825	10	strykowski	strykowski	PROPN
admet-292	825	11	.	.	PUNCT
admet-292	826	1	j.	j.	PROPN
admet-292	826	2	pharm	pharm	PROPN
admet-292	826	3	.	.	PUNCT
admet-292	827	1	sci	sci	PROPN
admet-292	827	2	.	.	PROPN
admet-292	828	1	78	78	NUM
admet-292	828	2	(	(	PUNCT
admet-292	828	3	1989	1989	NUM
admet-292	828	4	)	)	PUNCT
admet-292	828	5	767	767	NUM
admet-292	828	6	-	-	SYM
admet-292	828	7	770	770	NUM
admet-292	828	8	.	.	PUNCT
admet-292	829	1	[	[	X
admet-292	829	2	6	6	NUM
admet-292	829	3	]	]	X
admet-292	829	4	n.k	n.k	PROPN
admet-292	829	5	.	.	PROPN
admet-292	829	6	pandit	pandit	PROPN
admet-292	829	7	,	,	PUNCT
admet-292	829	8	j.m	j.m	PROPN
admet-292	829	9	.	.	PROPN
admet-292	829	10	strykowski	strykowski	PROPN
admet-292	829	11	,	,	PUNCT
admet-292	829	12	l.	l.	PROPN
admet-292	829	13	shtohryn	shtohryn	PROPN
admet-292	829	14	.	.	PUNCT
admet-292	830	1	int	int	PROPN
admet-292	830	2	.	.	PUNCT
admet-292	831	1	j.	j.	PROPN
admet-292	831	2	pharm	pharm	PROPN
admet-292	831	3	.	.	PUNCT
admet-292	832	1	50	50	NUM
admet-292	832	2	(	(	PUNCT
admet-292	832	3	1989	1989	NUM
admet-292	832	4	)	)	PUNCT
admet-292	832	5	7	7	NUM
admet-292	832	6	-	-	SYM
admet-292	832	7	13	13	NUM
admet-292	832	8	.	.	PUNCT
admet-292	833	1	[	[	X
admet-292	833	2	7	7	X
admet-292	833	3	]	]	X
admet-292	833	4	t.	t.	PROPN
admet-292	833	5	higuchi	higuchi	PROPN
admet-292	833	6	,	,	PUNCT
admet-292	833	7	a.k	a.k	PROPN
admet-292	833	8	connors	connor	NOUN
admet-292	833	9	.	.	PUNCT
admet-292	834	1	adv	adv	PROPN
admet-292	834	2	.	.	PUNCT
admet-292	835	1	anal	anal	PROPN
admet-292	835	2	.	.	PUNCT
admet-292	836	1	chem	chem	PROPN
admet-292	836	2	.	.	PUNCT
admet-292	837	1	instrum	instrum	NOUN
admet-292	837	2	.	.	PUNCT
admet-292	838	1	4	4	NUM
admet-292	838	2	(	(	PUNCT
admet-292	838	3	1965	1965	NUM
admet-292	838	4	)	)	PUNCT
admet-292	838	5	117	117	NUM
admet-292	838	6	-	-	SYM
admet-292	838	7	212	212	NUM
admet-292	838	8	.	.	PUNCT
admet-292	839	1	[	[	X
admet-292	839	2	8	8	NUM
admet-292	839	3	]	]	X
admet-292	839	4	d.j.w	d.j.w	NOUN
admet-292	839	5	.	.	PUNCT
admet-292	839	6	grant	grant	PROPN
admet-292	839	7	,	,	PUNCT
admet-292	839	8	t.	t.	PROPN
admet-292	839	9	higuchi	higuchi	PROPN
admet-292	839	10	.	.	PUNCT
admet-292	840	1	solubility	solubility	NOUN
admet-292	840	2	behavior	behavior	NOUN
admet-292	840	3	of	of	ADP
admet-292	840	4	organic	organic	ADJ
admet-292	840	5	compounds	compound	NOUN
admet-292	840	6	,	,	PUNCT
admet-292	840	7	john	john	PROPN
admet-292	840	8	wiley	wiley	PROPN
admet-292	840	9	&	&	CCONJ
admet-292	840	10	sons	son	NOUN
admet-292	840	11	,	,	PUNCT
admet-292	840	12	new	new	PROPN
admet-292	840	13	york	york	PROPN
admet-292	840	14	,	,	PUNCT
admet-292	840	15	1990	1990	NUM
admet-292	840	16	.	.	PUNCT
admet-292	841	1	[	[	X
admet-292	841	2	9	9	NUM
admet-292	841	3	]	]	X
admet-292	841	4	j.t	j.t	PROPN
admet-292	841	5	.	.	PROPN
admet-292	841	6	carstensen	carstensen	NOUN
admet-292	841	7	.	.	PUNCT
admet-292	842	1	advanced	advanced	ADJ
admet-292	842	2	pharmaceutical	pharmaceutical	ADJ
admet-292	842	3	solids	solid	NOUN
admet-292	842	4	,	,	PUNCT
admet-292	842	5	marcel	marcel	PROPN
admet-292	842	6	dekker	dekker	PROPN
admet-292	842	7	,	,	PUNCT
admet-292	842	8	inc	inc	PROPN
admet-292	842	9	.	.	PROPN
admet-292	842	10	,	,	PUNCT
admet-292	842	11	new	new	PROPN
admet-292	842	12	york	york	PROPN
admet-292	842	13	,	,	PUNCT
admet-292	842	14	2001	2001	NUM
admet-292	842	15	.	.	PUNCT
admet-292	843	1	[	[	X
admet-292	843	2	10	10	NUM
admet-292	843	3	]	]	PUNCT
admet-292	843	4	m.	m.	NOUN
admet-292	843	5	pudipeddi	pudipeddi	NOUN
admet-292	843	6	,	,	PUNCT
admet-292	843	7	a.t.m	a.t.m	PROPN
admet-292	843	8	.	.	PUNCT
admet-292	844	1	serajuddin	serajuddin	PROPN
admet-292	844	2	,	,	PUNCT
admet-292	844	3	d.j.w	d.j.w	PROPN
admet-292	844	4	.	.	PUNCT
admet-292	844	5	grant	grant	PROPN
admet-292	844	6	,	,	PUNCT
admet-292	844	7	p.h	p.h	PROPN
admet-292	844	8	.	.	PROPN
admet-292	844	9	stahl	stahl	PROPN
admet-292	844	10	.	.	PUNCT
admet-292	845	1	solubility	solubility	NOUN
admet-292	845	2	and	and	CCONJ
admet-292	845	3	dissolution	dissolution	NOUN
admet-292	845	4	of	of	ADP
admet-292	845	5	weak	weak	ADJ
admet-292	845	6	acids	acid	NOUN
admet-292	845	7	,	,	PUNCT
admet-292	845	8	bases	basis	NOUN
admet-292	845	9	,	,	PUNCT
admet-292	845	10	and	and	CCONJ
admet-292	845	11	salts	salt	NOUN
admet-292	845	12	.	.	PUNCT
admet-292	846	1	in	in	ADP
admet-292	846	2	:	:	PUNCT
admet-292	846	3	p.h	p.h	PROPN
admet-292	846	4	.	.	PROPN
admet-292	846	5	stahl	stahl	PROPN
admet-292	846	6	,	,	PUNCT
admet-292	846	7	c.g	c.g	PROPN
admet-292	846	8	.	.	PROPN
admet-292	846	9	wermuth	wermuth	PROPN
admet-292	846	10	(	(	PUNCT
admet-292	846	11	eds	ed	NOUN
admet-292	846	12	.	.	PUNCT
admet-292	846	13	)	)	PUNCT
admet-292	846	14	.	.	PUNCT
admet-292	847	1	handbook	handbook	NOUN
admet-292	847	2	of	of	ADP
admet-292	847	3	pharmaceutical	pharmaceutical	ADJ
admet-292	847	4	salts	salt	NOUN
admet-292	847	5	:	:	PUNCT
admet-292	847	6	properties	property	NOUN
admet-292	847	7	,	,	PUNCT
admet-292	847	8	selection	selection	NOUN
admet-292	847	9	,	,	PUNCT
admet-292	847	10	and	and	CCONJ
admet-292	847	11	use	use	NOUN
admet-292	847	12	,	,	PUNCT
admet-292	847	13	wiley	wiley	PROPN
admet-292	847	14	-	-	PUNCT
admet-292	847	15	vch	vch	PROPN
admet-292	847	16	,	,	PUNCT
admet-292	847	17	weinheim	weinheim	PROPN
admet-292	847	18	,	,	PUNCT
admet-292	847	19	2002	2002	NUM
admet-292	847	20	,	,	PUNCT
admet-292	847	21	pp	pp	ADJ
admet-292	847	22	.	.	PUNCT
admet-292	848	1	19	19	NUM
admet-292	848	2	-	-	SYM
admet-292	848	3	39	39	NUM
admet-292	848	4	.	.	PUNCT
admet-292	849	1	[	[	X
admet-292	849	2	11	11	NUM
admet-292	849	3	]	]	X
admet-292	849	4	b.d	b.d	PROPN
admet-292	849	5	.	.	PROPN
admet-292	849	6	anderson	anderson	PROPN
admet-292	849	7	,	,	PUNCT
admet-292	849	8	k.p	k.p	PROPN
admet-292	849	9	.	.	PROPN
admet-292	849	10	flora	flora	PROPN
admet-292	849	11	.	.	PUNCT
admet-292	850	1	preparation	preparation	NOUN
admet-292	850	2	of	of	ADP
admet-292	850	3	water	water	NOUN
admet-292	850	4	-	-	PUNCT
admet-292	850	5	soluble	soluble	ADJ
admet-292	850	6	compounds	compound	NOUN
admet-292	850	7	through	through	ADP
admet-292	850	8	salt	salt	NOUN
admet-292	850	9	formation	formation	NOUN
admet-292	850	10	.	.	PUNCT
admet-292	851	1	in	in	ADP
admet-292	851	2	:	:	PUNCT
admet-292	851	3	wermuth	wermuth	NOUN
admet-292	851	4	,	,	PUNCT
admet-292	851	5	c.g	c.g	PROPN
admet-292	851	6	.	.	PROPN
admet-292	851	7	(	(	PUNCT
admet-292	851	8	ed	ed	NOUN
admet-292	851	9	.	.	PUNCT
admet-292	851	10	)	)	PUNCT
admet-292	851	11	,	,	PUNCT
admet-292	851	12	the	the	DET
admet-292	851	13	practice	practice	NOUN
admet-292	851	14	of	of	ADP
admet-292	851	15	medicinal	medicinal	ADJ
admet-292	851	16	chemistry	chemistry	NOUN
admet-292	851	17	.	.	PUNCT
admet-292	852	1	academic	academic	ADJ
admet-292	852	2	press	press	PROPN
admet-292	852	3	,	,	PUNCT
admet-292	852	4	london	london	PROPN
admet-292	852	5	,	,	PUNCT
admet-292	852	6	1996	1996	NUM
admet-292	852	7	,	,	PUNCT
admet-292	852	8	pp	pp	ADV
admet-292	852	9	.	.	PUNCT
admet-292	853	1	739	739	NUM
admet-292	853	2	-	-	SYM
admet-292	853	3	754	754	NUM
admet-292	853	4	.	.	PUNCT
admet-292	854	1	[	[	X
admet-292	854	2	12	12	NUM
admet-292	854	3	]	]	X
admet-292	854	4	w.q	w.q	PROPN
admet-292	854	5	.	.	PUNCT
admet-292	854	6	tong	tong	PROPN
admet-292	854	7	,	,	PUNCT
admet-292	854	8	g.	g.	PROPN
admet-292	854	9	whitesell	whitesell	PROPN
admet-292	854	10	.	.	PUNCT
admet-292	855	1	pharm	pharm	PROPN
admet-292	855	2	.	.	PUNCT
admet-292	856	1	dev	dev	PROPN
admet-292	856	2	.	.	PUNCT
admet-292	856	3	technol	technol	PROPN
admet-292	856	4	.	.	PROPN
admet-292	856	5	3	3	NUM
admet-292	856	6	(	(	PUNCT
admet-292	856	7	1998	1998	NUM
admet-292	856	8	)	)	PUNCT
admet-292	857	1	215	215	NUM
admet-292	857	2	-	-	SYM
admet-292	857	3	223	223	NUM
admet-292	857	4	.	.	PUNCT
admet-292	858	1	[	[	X
admet-292	858	2	13	13	NUM
admet-292	858	3	]	]	SYM
admet-292	858	4	a.t.m	a.t.m	NOUN
admet-292	858	5	.	.	PROPN
admet-292	858	6	,	,	PUNCT
admet-292	858	7	serajuddin	serajuddin	PROPN
admet-292	858	8	,	,	PUNCT
admet-292	858	9	m.	m.	NOUN
admet-292	858	10	pudipeddi	pudipeddi	NOUN
admet-292	858	11	.	.	PUNCT
admet-292	859	1	salt	salt	NOUN
admet-292	859	2	selection	selection	NOUN
admet-292	859	3	strategies	strategy	NOUN
admet-292	859	4	.	.	PUNCT
admet-292	860	1	in	in	ADP
admet-292	860	2	:	:	PUNCT
admet-292	860	3	p.h	p.h	PROPN
admet-292	860	4	.	.	PROPN
admet-292	860	5	stahl	stahl	PROPN
admet-292	860	6	,	,	PUNCT
admet-292	860	7	c.g	c.g	PROPN
admet-292	860	8	.	.	PROPN
admet-292	860	9	wermuth	wermuth	PROPN
admet-292	860	10	(	(	PUNCT
admet-292	860	11	eds	ed	NOUN
admet-292	860	12	.	.	PUNCT
admet-292	860	13	)	)	PUNCT
admet-292	860	14	,	,	PUNCT
admet-292	860	15	handbook	handbook	NOUN
admet-292	860	16	of	of	ADP
admet-292	860	17	pharmaceutical	pharmaceutical	ADJ
admet-292	860	18	salts	salt	NOUN
admet-292	860	19	:	:	PUNCT
admet-292	860	20	properties	property	NOUN
admet-292	860	21	,	,	PUNCT
admet-292	860	22	selection	selection	NOUN
admet-292	860	23	,	,	PUNCT
admet-292	860	24	and	and	CCONJ
admet-292	860	25	use	use	NOUN
admet-292	860	26	,	,	PUNCT
admet-292	860	27	wiley	wiley	PROPN
admet-292	860	28	-	-	PUNCT
admet-292	860	29	vch	vch	PROPN
admet-292	860	30	,	,	PUNCT
admet-292	860	31	weinheim	weinheim	PROPN
admet-292	860	32	,	,	PUNCT
admet-292	860	33	2002	2002	NUM
admet-292	860	34	,	,	PUNCT
admet-292	860	35	pp	pp	ADJ
admet-292	860	36	.	.	PUNCT
admet-292	861	1	135	135	NUM
admet-292	861	2	-	-	SYM
admet-292	861	3	160	160	NUM
admet-292	861	4	.	.	PUNCT
admet-292	862	1	[	[	X
admet-292	862	2	14	14	NUM
admet-292	862	3	]	]	X
admet-292	862	4	a.t	a.t	PROPN
admet-292	862	5	.	.	PUNCT
admet-292	862	6	serajuddin	serajuddin	PROPN
admet-292	862	7	.	.	PUNCT
admet-292	863	1	adv	adv	PROPN
admet-292	863	2	.	.	PUNCT
admet-292	863	3	drug	drug	PROPN
admet-292	863	4	deliv	deliv	PROPN
admet-292	863	5	.	.	PUNCT
admet-292	864	1	rev	rev	PROPN
admet-292	864	2	.	.	PROPN
admet-292	864	3	59	59	NUM
admet-292	864	4	(	(	PUNCT
admet-292	864	5	2007	2007	NUM
admet-292	864	6	)	)	PUNCT
admet-292	864	7	603	603	NUM
admet-292	864	8	-	-	SYM
admet-292	864	9	613	613	NUM
admet-292	864	10	.	.	PUNCT
admet-292	865	1	[	[	X
admet-292	865	2	15	15	NUM
admet-292	865	3	]	]	X
admet-292	865	4	a.f	a.f	PROPN
admet-292	865	5	.	.	PROPN
admet-292	865	6	casares	casares	PROPN
admet-292	865	7	,	,	PUNCT
admet-292	865	8	w.m	w.m	PROPN
admet-292	865	9	.	.	PROPN
admet-292	865	10	nap	nap	PROPN
admet-292	865	11	,	,	PUNCT
admet-292	865	12	g.t	g.t	PROPN
admet-292	865	13	.	.	PROPN
admet-292	865	14	figás	figás	PROPN
admet-292	865	15	,	,	PUNCT
admet-292	865	16	p.	p.	NOUN
admet-292	865	17	huizenga	huizenga	PROPN
admet-292	865	18	,	,	PUNCT
admet-292	865	19	r.	r.	PROPN
admet-292	865	20	groot	groot	PROPN
admet-292	865	21	,	,	PUNCT
admet-292	865	22	m.	m.	NOUN
admet-292	865	23	hoffmann	hoffmann	PROPN
admet-292	865	24	.	.	PUNCT
admet-292	866	1	an	an	DET
admet-292	866	2	evaluation	evaluation	NOUN
admet-292	866	3	of	of	ADP
admet-292	866	4	salt	salt	NOUN
admet-292	866	5	screening	screen	VERB
admet-292	866	6	methodologies	methodology	NOUN
admet-292	866	7	.	.	PUNCT
admet-292	867	1	j.	j.	PROPN
admet-292	867	2	pharm	pharm	PROPN
admet-292	867	3	.	.	PUNCT
admet-292	868	1	pharmacol	pharmacol	PROPN
admet-292	868	2	.	.	PROPN
admet-292	869	1	67	67	NUM
admet-292	869	2	(	(	PUNCT
admet-292	869	3	2015	2015	NUM
admet-292	869	4	)	)	PUNCT
admet-292	869	5	812	812	NUM
admet-292	869	6	-	-	SYM
admet-292	869	7	822	822	NUM
admet-292	869	8	.	.	PUNCT
admet-292	870	1	[	[	X
admet-292	870	2	16	16	NUM
admet-292	870	3	]	]	X
admet-292	870	4	p.h	p.h	PROPN
admet-292	870	5	.	.	PROPN
admet-292	870	6	stahl	stahl	PROPN
admet-292	870	7	,	,	PUNCT
admet-292	870	8	c.g	c.g	PROPN
admet-292	870	9	.	.	PROPN
admet-292	870	10	wermuth	wermuth	PROPN
admet-292	870	11	(	(	PUNCT
admet-292	870	12	eds	ed	NOUN
admet-292	870	13	.	.	PUNCT
admet-292	870	14	)	)	PUNCT
admet-292	870	15	.	.	PUNCT
admet-292	871	1	handbook	handbook	NOUN
admet-292	871	2	of	of	ADP
admet-292	871	3	pharmaceutical	pharmaceutical	ADJ
admet-292	871	4	salts	salt	NOUN
admet-292	871	5	properties	property	NOUN
admet-292	871	6	,	,	PUNCT
admet-292	871	7	selection	selection	NOUN
admet-292	871	8	,	,	PUNCT
admet-292	871	9	and	and	CCONJ
admet-292	871	10	use	use	NOUN
admet-292	871	11	.	.	PUNCT
admet-292	872	1	john	john	PROPN
admet-292	872	2	wiley	wiley	PROPN
admet-292	872	3	&	&	CCONJ
admet-292	872	4	sons	son	NOUN
admet-292	872	5	,	,	PUNCT
admet-292	872	6	new	new	PROPN
admet-292	872	7	york	york	PROPN
admet-292	872	8	,	,	PUNCT
admet-292	872	9	2008	2008	NUM
admet-292	872	10	,	,	PUNCT
admet-292	872	11	374	374	NUM
admet-292	872	12	pp	pp	NOUN
admet-292	872	13	.	.	PUNCT
admet-292	873	1	[	[	X
admet-292	873	2	17	17	NUM
admet-292	873	3	]	]	X
admet-292	873	4	h.g	h.g	PROPN
admet-292	873	5	.	.	PUNCT
admet-292	873	6	brittain	brittain	PROPN
admet-292	873	7	.	.	PUNCT
admet-292	874	1	j.	j.	PROPN
admet-292	874	2	pharm	pharm	PROPN
admet-292	874	3	.	.	PUNCT
admet-292	875	1	sci	sci	PROPN
admet-292	875	2	.	.	PROPN
admet-292	876	1	86	86	NUM
admet-292	876	2	(	(	PUNCT
admet-292	876	3	1997	1997	NUM
admet-292	876	4	)	)	PUNCT
admet-292	876	5	405	405	NUM
admet-292	876	6	-	-	SYM
admet-292	876	7	411	411	NUM
admet-292	876	8	.	.	PUNCT
admet-292	877	1	[	[	X
admet-292	877	2	18	18	NUM
admet-292	877	3	]	]	PUNCT
admet-292	877	4	m.	m.	NOUN
admet-292	877	5	pudipeddi	pudipeddi	NOUN
admet-292	877	6	,	,	PUNCT
admet-292	877	7	a.t.m	a.t.m	NOUN
admet-292	877	8	.	.	PUNCT
admet-292	877	9	serajuddin	serajuddin	PROPN
admet-292	877	10	.	.	PUNCT
admet-292	878	1	j.	j.	PROPN
admet-292	878	2	pharm	pharm	PROPN
admet-292	878	3	.	.	PUNCT
admet-292	879	1	sci	sci	PROPN
admet-292	879	2	.	.	PROPN
admet-292	880	1	94	94	NUM
admet-292	880	2	(	(	PUNCT
admet-292	880	3	2005	2005	NUM
admet-292	880	4	)	)	PUNCT
admet-292	880	5	929	929	NUM
admet-292	880	6	-	-	SYM
admet-292	880	7	939	939	NUM
admet-292	880	8	.	.	PUNCT
admet-292	881	1	[	[	X
admet-292	881	2	19	19	NUM
admet-292	881	3	]	]	SYM
admet-292	881	4	p.h	p.h	PROPN
admet-292	881	5	.	.	PROPN
admet-292	881	6	stahl	stahl	PROPN
admet-292	881	7	.	.	PUNCT
admet-292	882	1	salt	salt	NOUN
admet-292	882	2	selection	selection	NOUN
admet-292	882	3	.	.	PUNCT
admet-292	883	1	in	in	ADP
admet-292	883	2	:	:	PUNCT
admet-292	883	3	r.	r.	PROPN
admet-292	883	4	hilfiker	hilfiker	PROPN
admet-292	883	5	(	(	PUNCT
admet-292	883	6	ed	ed	NOUN
admet-292	883	7	.	.	PUNCT
admet-292	883	8	)	)	PUNCT
admet-292	883	9	.	.	PUNCT
admet-292	884	1	polymorphism	polymorphism	NOUN
admet-292	884	2	in	in	ADP
admet-292	884	3	pharmaceutical	pharmaceutical	NOUN
admet-292	884	4	industry	industry	NOUN
admet-292	884	5	,	,	PUNCT
admet-292	884	6	wiley	wiley	PROPN
admet-292	884	7	-	-	PUNCT
admet-292	884	8	vch	vch	PROPN
admet-292	884	9	,	,	PUNCT
admet-292	884	10	weinheim	weinheim	PROPN
admet-292	884	11	,	,	PUNCT
admet-292	884	12	2006	2006	NUM
admet-292	884	13	,	,	PUNCT
admet-292	884	14	pp	pp	ADV
admet-292	884	15	.	.	PUNCT
admet-292	885	1	309	309	NUM
admet-292	885	2	-	-	SYM
admet-292	885	3	322	322	NUM
admet-292	885	4	.	.	PUNCT
admet-292	886	1	[	[	X
admet-292	886	2	20	20	NUM
admet-292	886	3	]	]	PUNCT
admet-292	886	4	j.	j.	PROPN
admet-292	886	5	bernstein	bernstein	PROPN
admet-292	886	6	.	.	PUNCT
admet-292	886	7	polymorphism	polymorphism	NOUN
admet-292	886	8	of	of	ADP
admet-292	886	9	molecular	molecular	ADJ
admet-292	886	10	crystals	crystal	NOUN
admet-292	886	11	.	.	PUNCT
admet-292	887	1	2007	2007	NUM
admet-292	887	2	,	,	PUNCT
admet-292	887	3	oxford	oxford	PROPN
admet-292	887	4	university	university	PROPN
admet-292	887	5	press	press	NOUN
admet-292	887	6	,	,	PUNCT
admet-292	887	7	oxford	oxford	PROPN
admet-292	887	8	,	,	PUNCT
admet-292	887	9	428	428	NUM
admet-292	887	10	pp	pp	NOUN
admet-292	887	11	.	.	PUNCT
admet-292	888	1	[	[	X
admet-292	888	2	21	21	NUM
admet-292	888	3	]	]	PUNCT
admet-292	888	4	a.	a.	NOUN
admet-292	888	5	avdeef	avdeef	PROPN
admet-292	888	6	.	.	PUNCT
admet-292	889	1	adv	adv	PROPN
admet-292	889	2	.	.	PUNCT
admet-292	889	3	drug	drug	PROPN
admet-292	889	4	deliv	deliv	PROPN
admet-292	889	5	.	.	PUNCT
admet-292	890	1	rev	rev	PROPN
admet-292	890	2	.	.	PROPN
admet-292	890	3	59	59	NUM
admet-292	890	4	(	(	PUNCT
admet-292	890	5	2007	2007	NUM
admet-292	890	6	)	)	PUNCT
admet-292	890	7	568	568	NUM
admet-292	890	8	-	-	SYM
admet-292	890	9	590	590	NUM
admet-292	890	10	.	.	PUNCT
admet-292	891	1	[	[	X
admet-292	891	2	22	22	NUM
admet-292	891	3	]	]	X
admet-292	891	4	g.	g.	PROPN
admet-292	891	5	völgyi	völgyi	PROPN
admet-292	891	6	,	,	PUNCT
admet-292	891	7	a.	a.	NOUN
admet-292	891	8	marosi	marosi	PROPN
admet-292	891	9	,	,	PUNCT
admet-292	891	10	k.	k.	PROPN
admet-292	891	11	takács	takács	PROPN
admet-292	891	12	-	-	PUNCT
admet-292	891	13	novák	novák	PROPN
admet-292	891	14	,	,	PUNCT
admet-292	891	15	a.	a.	PROPN
admet-292	891	16	avdeef	avdeef	PROPN
admet-292	891	17	.	.	PUNCT
admet-292	892	1	admet	admet	PROPN
admet-292	892	2	&	&	CCONJ
admet-292	892	3	dmpk	dmpk	PROPN
admet-292	892	4	1	1	NUM
admet-292	892	5	(	(	PUNCT
admet-292	892	6	2013	2013	NUM
admet-292	892	7	)	)	PUNCT
admet-292	892	8	48	48	NUM
admet-292	892	9	-	-	SYM
admet-292	892	10	62	62	NUM
admet-292	892	11	.	.	PUNCT
admet-292	893	1	[	[	X
admet-292	893	2	23	23	NUM
admet-292	893	3	]	]	PUNCT
admet-292	893	4	a.	a.	NOUN
admet-292	893	5	avdeef	avdeef	PROPN
admet-292	893	6	.	.	PUNCT
admet-292	894	1	admet	admet	PROPN
admet-292	894	2	&	&	CCONJ
admet-292	894	3	dmpk	dmpk	PROPN
admet-292	894	4	2	2	NUM
admet-292	894	5	(	(	PUNCT
admet-292	894	6	2014	2014	NUM
admet-292	894	7	)	)	PUNCT
admet-292	894	8	33	33	NUM
admet-292	894	9	-	-	SYM
admet-292	894	10	42	42	NUM
admet-292	894	11	.	.	PUNCT
admet-292	895	1	[	[	X
admet-292	895	2	24	24	NUM
admet-292	895	3	]	]	PUNCT
admet-292	895	4	a.	a.	NOUN
admet-292	895	5	avdeef	avdeef	PROPN
admet-292	895	6	.	.	PUNCT
admet-292	896	1	admet	admet	PROPN
admet-292	896	2	&	&	CCONJ
admet-292	896	3	dmpk	dmpk	PROPN
admet-292	896	4	2	2	NUM
admet-292	896	5	(	(	PUNCT
admet-292	896	6	2014	2014	NUM
admet-292	896	7	)	)	PUNCT
admet-292	896	8	43	43	NUM
admet-292	896	9	-	-	SYM
admet-292	896	10	55	55	NUM
admet-292	896	11	.	.	PUNCT
admet-292	897	1	[	[	X
admet-292	897	2	25	25	NUM
admet-292	897	3	]	]	PUNCT
admet-292	897	4	g.	g.	NOUN
admet-292	897	5	butcher	butcher	PROPN
admet-292	897	6	,	,	PUNCT
admet-292	897	7	j.	j.	PROPN
admet-292	897	8	comer	comer	PROPN
admet-292	897	9	,	,	PUNCT
admet-292	897	10	a.	a.	NOUN
admet-292	897	11	avdeef	avdeef	PROPN
admet-292	897	12	.	.	PUNCT
admet-292	898	1	admet	admet	PROPN
admet-292	898	2	&	&	CCONJ
admet-292	898	3	dmpk	dmpk	PROPN
admet-292	898	4	3	3	NUM
admet-292	898	5	(	(	PUNCT
admet-292	898	6	2015	2015	NUM
admet-292	898	7	)	)	PUNCT
admet-292	898	8	131	131	NUM
admet-292	898	9	-	-	SYM
admet-292	898	10	140	140	NUM
admet-292	898	11	.	.	PUNCT
admet-292	899	1	[	[	X
admet-292	899	2	26	26	NUM
admet-292	899	3	]	]	PUNCT
admet-292	899	4	a.	a.	NOUN
admet-292	899	5	avdeef	avdeef	PROPN
admet-292	899	6	.	.	PUNCT
admet-292	900	1	admet	admet	PROPN
admet-292	900	2	&	&	CCONJ
admet-292	900	3	dmpk	dmpk	PROPN
admet-292	900	4	3	3	NUM
admet-292	900	5	(	(	PUNCT
admet-292	900	6	2015	2015	NUM
admet-292	900	7	)	)	PUNCT
admet-292	900	8	298	298	NUM
admet-292	900	9	-	-	SYM
admet-292	900	10	344	344	NUM
admet-292	900	11	.	.	PUNCT
admet-292	901	1	[	[	X
admet-292	901	2	27	27	NUM
admet-292	901	3	]	]	PUNCT
admet-292	901	4	a.	a.	NOUN
admet-292	901	5	avdeef	avdeef	PROPN
admet-292	901	6	.	.	PUNCT
admet-292	902	1	absorption	absorption	NOUN
admet-292	902	2	and	and	CCONJ
admet-292	902	3	drug	drug	NOUN
admet-292	902	4	development	development	PROPN
admet-292	902	5	second	second	PROPN
admet-292	902	6	edition	edition	PROPN
admet-292	902	7	.	.	PUNCT
admet-292	903	1	wiley	wiley	PROPN
admet-292	903	2	-	-	PUNCT
admet-292	903	3	interscience	interscience	PROPN
admet-292	903	4	:	:	PUNCT
admet-292	903	5	new	new	PROPN
admet-292	903	6	york	york	PROPN
admet-292	903	7	.	.	PUNCT
admet-292	904	1	2012	2012	NUM
admet-292	904	2	,	,	PUNCT
admet-292	904	3	pp	pp	ADV
admet-292	904	4	.	.	PUNCT
admet-292	905	1	251	251	NUM
admet-292	905	2	-	-	SYM
admet-292	905	3	318	318	NUM
admet-292	905	4	.	.	PUNCT
admet-292	906	1	[	[	X
admet-292	906	2	28	28	NUM
admet-292	906	3	]	]	X
admet-292	906	4	s.j	s.j	PROPN
admet-292	906	5	.	.	PROPN
admet-292	906	6	nehm	nehm	PROPN
admet-292	906	7	,	,	PUNCT
admet-292	906	8	b.	b.	PROPN
admet-292	906	9	rodriguez	rodriguez	PROPN
admet-292	906	10	-	-	PUNCT
admet-292	906	11	spong	spong	PROPN
admet-292	906	12	,	,	PUNCT
admet-292	906	13	n.	n.	PROPN
admet-292	906	14	rodriguez	rodriguez	PROPN
admet-292	906	15	-	-	PUNCT
admet-292	906	16	hornedo	hornedo	PROPN
admet-292	906	17	.	.	PUNCT
admet-292	907	1	cryst	cryst	PROPN
admet-292	907	2	.	.	PUNCT
admet-292	908	1	growth	growth	PROPN
admet-292	908	2	des	des	PROPN
admet-292	908	3	.	.	PROPN
admet-292	908	4	6	6	NUM
admet-292	908	5	(	(	PUNCT
admet-292	908	6	2006	2006	NUM
admet-292	908	7	)	)	PUNCT
admet-292	908	8	592	592	NUM
admet-292	908	9	-	-	SYM
admet-292	908	10	600	600	NUM
admet-292	908	11	.	.	PUNCT
admet-292	909	1	[	[	X
admet-292	909	2	29	29	NUM
admet-292	909	3	]	]	X
admet-292	909	4	l.s	l.s	PROPN
admet-292	909	5	.	.	PROPN
admet-292	909	6	reddy	reddy	PROPN
admet-292	909	7	,	,	PUNCT
admet-292	909	8	s.	s.	PROPN
admet-292	909	9	bethune	bethune	PROPN
admet-292	909	10	,	,	PUNCT
admet-292	909	11	a.	a.	NOUN
admet-292	909	12	jayasankar	jayasankar	PROPN
admet-292	909	13	,	,	PUNCT
admet-292	909	14	n.	n.	PROPN
admet-292	909	15	rodriguez	rodriguez	PROPN
admet-292	909	16	-	-	PUNCT
admet-292	909	17	hornedo	hornedo	PROPN
admet-292	909	18	.	.	PUNCT
admet-292	910	1	cryst	cryst	PROPN
admet-292	910	2	.	.	PUNCT
admet-292	911	1	growth	growth	PROPN
admet-292	911	2	des	des	PROPN
admet-292	911	3	.	.	PROPN
admet-292	911	4	9	9	NUM
admet-292	911	5	(	(	PUNCT
admet-292	911	6	2009	2009	NUM
admet-292	911	7	)	)	PUNCT
admet-292	911	8	378	378	NUM
admet-292	911	9	-	-	SYM
admet-292	911	10	385	385	NUM
admet-292	911	11	.	.	PUNCT
admet-292	912	1	[	[	X
admet-292	912	2	30	30	NUM
admet-292	912	3	]	]	X
admet-292	912	4	d.	d.	PROPN
admet-292	912	5	good	good	PROPN
admet-292	912	6	,	,	PUNCT
admet-292	912	7	n.	n.	PROPN
admet-292	912	8	rodríguez	rodríguez	PROPN
admet-292	912	9	-	-	PUNCT
admet-292	912	10	hornedo	hornedo	PROPN
admet-292	912	11	.	.	PUNCT
admet-292	913	1	cryst	cryst	PROPN
admet-292	913	2	.	.	PUNCT
admet-292	914	1	growth	growth	PROPN
admet-292	914	2	des	des	PROPN
admet-292	914	3	.	.	PROPN
admet-292	914	4	9	9	NUM
admet-292	914	5	(	(	PUNCT
admet-292	914	6	2009	2009	NUM
admet-292	914	7	)	)	PUNCT
admet-292	914	8	2252	2252	NUM
admet-292	914	9	-	-	SYM
admet-292	914	10	2264	2264	NUM
admet-292	914	11	.	.	PUNCT
admet-292	915	1	[	[	X
admet-292	915	2	31	31	NUM
admet-292	915	3	]	]	PUNCT
admet-292	915	4	s.	s.	PROPN
admet-292	915	5	bethune	bethune	PROPN
admet-292	915	6	,	,	PUNCT
admet-292	915	7	n.c	n.c	PROPN
admet-292	915	8	.	.	PROPN
admet-292	915	9	huang	huang	PROPN
admet-292	915	10	,	,	PUNCT
admet-292	915	11	a.	a.	NOUN
admet-292	915	12	jayasankar	jayasankar	PROPN
admet-292	915	13	,	,	PUNCT
admet-292	915	14	n.	n.	PROPN
admet-292	915	15	rodríguez	rodríguez	PROPN
admet-292	915	16	-	-	PUNCT
admet-292	915	17	hornedo	hornedo	PROPN
admet-292	915	18	.	.	PUNCT
admet-292	916	1	cryst	cryst	PROPN
admet-292	916	2	.	.	PUNCT
admet-292	917	1	growth	growth	PROPN
admet-292	917	2	des	des	PROPN
admet-292	917	3	.	.	PROPN
admet-292	917	4	9	9	NUM
admet-292	917	5	(	(	PUNCT
admet-292	917	6	2009	2009	NUM
admet-292	917	7	)	)	PUNCT
admet-292	917	8	976	976	NUM
admet-292	917	9	-	-	SYM
admet-292	917	10	3988	3988	NUM
admet-292	917	11	.	.	PUNCT
admet-292	918	1	[	[	X
admet-292	918	2	32	32	NUM
admet-292	918	3	]	]	X
admet-292	918	4	d.	d.	PROPN
admet-292	918	5	good	good	PROPN
admet-292	918	6	,	,	PUNCT
admet-292	918	7	n.	n.	PROPN
admet-292	918	8	rodriguez	rodriguez	PROPN
admet-292	918	9	-	-	PUNCT
admet-292	918	10	hornedo	hornedo	PROPN
admet-292	918	11	.	.	PUNCT
admet-292	919	1	cryst	cryst	PROPN
admet-292	919	2	.	.	PUNCT
admet-292	920	1	growth	growth	PROPN
admet-292	920	2	des	des	PROPN
admet-292	920	3	.	.	PROPN
admet-292	920	4	10	10	NUM
admet-292	920	5	(	(	PUNCT
admet-292	920	6	2010	2010	NUM
admet-292	920	7	)	)	PUNCT
admet-292	920	8	1028	1028	NUM
admet-292	920	9	-	-	SYM
admet-292	920	10	1032	1032	NUM
admet-292	920	11	.	.	PUNCT
admet-292	921	1	[	[	X
admet-292	921	2	33	33	NUM
admet-292	921	3	]	]	X
admet-292	921	4	n.	n.	PROPN
admet-292	921	5	huang	huang	PROPN
admet-292	921	6	,	,	PUNCT
admet-292	921	7	n.	n.	PROPN
admet-292	921	8	rodríguez	rodríguez	PROPN
admet-292	921	9	-	-	PUNCT
admet-292	921	10	hornedo	hornedo	PROPN
admet-292	921	11	.	.	PUNCT
admet-292	921	12	cryst	cryst	PROPN
admet-292	921	13	.	.	PUNCT
admet-292	922	1	growth	growth	PROPN
admet-292	922	2	des	des	PROPN
admet-292	922	3	.	.	PROPN
admet-292	922	4	 	 	SPACE
admet-292	922	5	10	10	NUM
admet-292	922	6	(	(	PUNCT
admet-292	922	7	2010	2010	NUM
admet-292	922	8	)	)	PUNCT
admet-292	922	9	2050	2050	NUM
admet-292	922	10	-	-	SYM
admet-292	922	11	2053	2053	NUM
admet-292	922	12	.	.	PUNCT
admet-292	923	1	alex	alex	PROPN
admet-292	923	2	avdeef	avdeef	PROPN
admet-292	923	3	et	et	PROPN
admet-292	923	4	al	al	PROPN
admet-292	923	5	.	.	PROPN
admet-292	923	6	admet	admet	PROPN
admet-292	923	7	&	&	CCONJ
admet-292	923	8	dmpk	dmpk	PROPN
admet-292	923	9	4(2	4(2	NUM
admet-292	923	10	)	)	PUNCT
admet-292	923	11	(	(	PUNCT
admet-292	923	12	2016	2016	NUM
admet-292	923	13	)	)	PUNCT
admet-292	923	14	117	117	NUM
admet-292	923	15	-	-	SYM
admet-292	923	16	178	178	NUM
admet-292	923	17	158	158	NUM
admet-292	923	18	[	[	X
admet-292	923	19	34	34	NUM
admet-292	923	20	]	]	PUNCT
admet-292	923	21	a.	a.	NOUN
admet-292	923	22	alhalaweh	alhalaweh	PROPN
admet-292	923	23	,	,	PUNCT
admet-292	923	24	l.	l.	PROPN
admet-292	923	25	roy	roy	PROPN
admet-292	923	26	,	,	PUNCT
admet-292	923	27	n.	n.	PROPN
admet-292	923	28	rodríguez	rodríguez	PROPN
admet-292	923	29	-	-	PUNCT
admet-292	923	30	hornedo	hornedo	PROPN
admet-292	923	31	.	.	PUNCT
admet-292	924	1	s.p	s.p	PROPN
admet-292	924	2	.	.	PROPN
admet-292	924	3	velaga	velaga	PROPN
admet-292	924	4	.	.	PUNCT
admet-292	925	1	molec	molec	PROPN
admet-292	925	2	.	.	PUNCT
admet-292	926	1	pharmaceut	pharmaceut	PROPN
admet-292	926	2	.	.	PUNCT
admet-292	926	3	 	 	SPACE
admet-292	926	4	9	9	NUM
admet-292	926	5	(	(	PUNCT
admet-292	926	6	2012	2012	NUM
admet-292	926	7	)	)	PUNCT
admet-292	926	8	2605	2605	NUM
admet-292	926	9	-	-	SYM
admet-292	926	10	2612	2612	NUM
admet-292	926	11	.	.	PUNCT
admet-292	927	1	[	[	X
admet-292	927	2	35	35	NUM
admet-292	927	3	]	]	X
admet-292	927	4	c.	c.	PROPN
admet-292	927	5	maheshwari	maheshwari	PROPN
admet-292	927	6	,	,	PUNCT
admet-292	927	7	v.	v.	CCONJ
admet-292	927	8	andré	andré	PROPN
admet-292	927	9	,	,	PUNCT
admet-292	927	10	s.	s.	PROPN
admet-292	927	11	reddy	reddy	PROPN
admet-292	927	12	,	,	PUNCT
admet-292	927	13	l.	l.	PROPN
admet-292	927	14	roy	roy	PROPN
admet-292	927	15	,	,	PUNCT
admet-292	927	16	t.	t.	PROPN
admet-292	927	17	duarte	duarte	PROPN
admet-292	927	18	,	,	PUNCT
admet-292	927	19	n.	n.	PROPN
admet-292	927	20	rodríguez	rodríguez	PROPN
admet-292	927	21	-	-	PUNCT
admet-292	927	22	hornedo	hornedo	PROPN
admet-292	927	23	.	.	PUNCT
admet-292	928	1	cryst	cryst	PROPN
admet-292	928	2	.	.	PUNCT
admet-292	929	1	eng	eng	PROPN
admet-292	929	2	.	.	PROPN
admet-292	929	3	comm	comm	NOUN
admet-292	929	4	.	.	PUNCT
admet-292	929	5	 	 	SPACE
admet-292	930	1	14	14	NUM
admet-292	930	2	(	(	PUNCT
admet-292	930	3	2012	2012	NUM
admet-292	930	4	)	)	PUNCT
admet-292	930	5	4801	4801	NUM
admet-292	930	6	-	-	SYM
admet-292	930	7	4811	4811	NUM
admet-292	930	8	.	.	PUNCT
admet-292	931	1	[	[	X
admet-292	931	2	36	36	NUM
admet-292	931	3	]	]	PUNCT
admet-292	931	4	a.	a.	NOUN
admet-292	931	5	alhalaweh	alhalaweh	PROPN
admet-292	931	6	,	,	PUNCT
admet-292	931	7	a.	a.	NOUN
admet-292	931	8	sokolowski	sokolowski	PROPN
admet-292	931	9	,	,	PUNCT
admet-292	931	10	n.	n.	PROPN
admet-292	931	11	rodríguez	rodríguez	PROPN
admet-292	931	12	-	-	PUNCT
admet-292	931	13	hornedo	hornedo	PROPN
admet-292	931	14	,	,	PUNCT
admet-292	931	15	s.p	s.p	PROPN
admet-292	931	16	.	.	PROPN
admet-292	931	17	velagacryst	velagacryst	NOUN
admet-292	931	18	.	.	PUNCT
admet-292	932	1	growth	growth	PROPN
admet-292	932	2	des	des	PROPN
admet-292	932	3	.	.	PROPN
admet-292	932	4	 	 	SPACE
admet-292	932	5	11	11	NUM
admet-292	932	6	(	(	PUNCT
admet-292	932	7	2011	2011	NUM
admet-292	932	8	)	)	PUNCT
admet-292	932	9	3923	3923	NUM
admet-292	932	10	-	-	SYM
admet-292	932	11	3929	3929	NUM
admet-292	932	12	.	.	PUNCT
admet-292	933	1	[	[	X
admet-292	933	2	37	37	NUM
admet-292	933	3	]	]	PUNCT
admet-292	933	4	j.	j.	PROPN
admet-292	933	5	wouters	wouters	PROPN
admet-292	933	6	,	,	PUNCT
admet-292	933	7	l.	l.	PROPN
admet-292	933	8	quere	quere	PROPN
admet-292	933	9	(	(	PUNCT
admet-292	933	10	eds	ed	NOUN
admet-292	933	11	.	.	PUNCT
admet-292	933	12	)	)	PUNCT
admet-292	933	13	,	,	PUNCT
admet-292	933	14	pharmaceutical	pharmaceutical	NOUN
admet-292	933	15	salts	salt	NOUN
admet-292	933	16	and	and	CCONJ
admet-292	933	17	co	co	NOUN
admet-292	933	18	-	-	NOUN
admet-292	933	19	crystals	crystal	NOUN
admet-292	933	20	,	,	PUNCT
admet-292	933	21	rsc	rsc	PROPN
admet-292	933	22	publishing	publishing	PROPN
admet-292	933	23	,	,	PUNCT
admet-292	933	24	london	london	PROPN
admet-292	933	25	,	,	PUNCT
admet-292	933	26	2011	2011	NUM
admet-292	933	27	,	,	PUNCT
admet-292	933	28	391	391	NUM
admet-292	933	29	pp	pp	NOUN
admet-292	933	30	.	.	PUNCT
admet-292	934	1	[	[	X
admet-292	934	2	38	38	NUM
admet-292	934	3	]	]	X
admet-292	934	4	d.	d.	PROPN
admet-292	934	5	murphy	murphy	PROPN
admet-292	934	6	,	,	PUNCT
admet-292	934	7	f.	f.	PROPN
admet-292	934	8	rodrıǵuez	rodrıǵuez	PROPN
admet-292	934	9	-	-	PROPN
admet-292	934	10	cintrón	cintrón	PROPN
admet-292	934	11	,	,	PUNCT
admet-292	934	12	b.	b.	PROPN
admet-292	934	13	langevin	langevin	PROPN
admet-292	934	14	,	,	PUNCT
admet-292	934	15	r.	r.	PROPN
admet-292	934	16	c.	c.	PROPN
admet-292	934	17	kelly	kelly	PROPN
admet-292	934	18	,	,	PUNCT
admet-292	934	19	n.	n.	PROPN
admet-292	934	20	rodrıǵuez	rodrıǵuez	NOUN
admet-292	934	21	-	-	PUNCT
admet-292	934	22	hornedo	hornedo	NOUN
admet-292	934	23	.	.	PUNCT
admet-292	935	1	int	int	NOUN
admet-292	935	2	.	.	PUNCT
admet-292	936	1	j.	j.	PROPN
admet-292	936	2	pharm	pharm	PROPN
admet-292	936	3	.	.	PUNCT
admet-292	937	1	246	246	NUM
admet-292	937	2	(	(	PUNCT
admet-292	937	3	2002	2002	NUM
admet-292	937	4	)	)	PUNCT
admet-292	938	1	121–134	121–134	NUM
admet-292	938	2	.	.	PUNCT
admet-292	939	1	[	[	X
admet-292	939	2	39	39	NUM
admet-292	939	3	]	]	X
admet-292	939	4	j.p	j.p	PROPN
admet-292	939	5	.	.	PROPN
admet-292	939	6	boetkera	boetkera	PROPN
admet-292	939	7	,	,	PUNCT
admet-292	939	8	j.	j.	PROPN
admet-292	939	9	rantanena	rantanena	PROPN
admet-292	939	10	,	,	PUNCT
admet-292	939	11	l.	l.	PROPN
admet-292	939	12	arnfasta	arnfasta	PROPN
admet-292	939	13	,	,	PUNCT
admet-292	939	14	m.	m.	PROPN
admet-292	939	15	doretha	doretha	PROPN
admet-292	939	16	,	,	PUNCT
admet-292	939	17	d.	d.	PROPN
admet-292	939	18	raijadaa	raijadaa	PROPN
admet-292	939	19	,	,	PUNCT
admet-292	939	20	k.	k.	PROPN
admet-292	939	21	loebmanna	loebmanna	PROPN
admet-292	939	22	,	,	PUNCT
admet-292	939	23	c.	c.	PROPN
admet-292	939	24	madsena	madsena	PROPN
admet-292	939	25	,	,	PUNCT
admet-292	939	26	j.	j.	PROPN
admet-292	939	27	khanb	khanb	PROPN
admet-292	939	28	,	,	PUNCT
admet-292	939	29	t.	t.	PROPN
admet-292	939	30	radesa	radesa	PROPN
admet-292	939	31	,	,	PUNCT
admet-292	939	32	a.	a.	NOUN
admet-292	939	33	müllertza	müllertza	PROPN
admet-292	939	34	,	,	PUNCT
admet-292	939	35	a.	a.	NOUN
admet-292	939	36	hawleyd	hawleyd	PROPN
admet-292	939	37	,	,	PUNCT
admet-292	939	38	d.	d.	PROPN
admet-292	939	39	thomase	thomase	PROPN
admet-292	939	40	,	,	PUNCT
admet-292	939	41	b.j	b.j	PROPN
admet-292	939	42	.	.	PROPN
admet-292	939	43	boyd	boyd	PROPN
admet-292	939	44	.	.	PUNCT
admet-292	940	1	eur	eur	PROPN
admet-292	940	2	.	.	PUNCT
admet-292	941	1	j.	j.	PROPN
admet-292	941	2	pharm	pharm	PROPN
admet-292	941	3	.	.	PUNCT
admet-292	942	1	biopharm	biopharm	PROPN
admet-292	942	2	.	.	PUNCT
admet-292	943	1	100	100	NUM
admet-292	943	2	(	(	PUNCT
admet-292	943	3	2016	2016	NUM
admet-292	943	4	)	)	PUNCT
admet-292	944	1	119–127	119–127	NUM
admet-292	944	2	.	.	PUNCT
admet-292	945	1	[	[	X
admet-292	945	2	40	40	NUM
admet-292	945	3	]	]	X
admet-292	945	4	h.n	h.n	PROPN
admet-292	945	5	.	.	PROPN
admet-292	945	6	po	po	PROPN
admet-292	945	7	,	,	PUNCT
admet-292	945	8	n.m	n.m	PROPN
admet-292	945	9	.	.	PROPN
admet-292	945	10	senozan	senozan	PROPN
admet-292	945	11	.	.	PUNCT
admet-292	946	1	j.	j.	PROPN
admet-292	946	2	chem	chem	PROPN
admet-292	946	3	.	.	PUNCT
admet-292	947	1	educ	educ	PROPN
admet-292	947	2	.	.	PUNCT
admet-292	948	1	78	78	NUM
admet-292	948	2	(	(	PUNCT
admet-292	948	3	2001	2001	NUM
admet-292	948	4	)	)	PUNCT
admet-292	948	5	1499	1499	NUM
admet-292	948	6	-	-	SYM
admet-292	948	7	1503	1503	NUM
admet-292	948	8	.	.	PUNCT
admet-292	949	1	[	[	X
admet-292	949	2	41	41	NUM
admet-292	949	3	]	]	X
admet-292	949	4	g.	g.	PROPN
admet-292	949	5	völgyi	völgyi	PROPN
admet-292	949	6	,	,	PUNCT
admet-292	949	7	e.	e.	PROPN
admet-292	949	8	baka	baka	PROPN
admet-292	949	9	,	,	PUNCT
admet-292	949	10	k.j	k.j	PROPN
admet-292	949	11	.	.	PROPN
admet-292	949	12	box	box	PROPN
admet-292	949	13	,	,	PUNCT
admet-292	949	14	j.e.a	j.e.a	PROPN
admet-292	949	15	.	.	PUNCT
admet-292	949	16	comer	comer	PROPN
admet-292	949	17	,	,	PUNCT
admet-292	949	18	k.	k.	PROPN
admet-292	949	19	takács	takács	PROPN
admet-292	949	20	-	-	PUNCT
admet-292	949	21	novák	novák	PROPN
admet-292	949	22	.	.	PROPN
admet-292	950	1	anal	anal	PROPN
admet-292	950	2	.	.	PUNCT
admet-292	951	1	chim	chim	PROPN
admet-292	951	2	.	.	PUNCT
admet-292	952	1	acta	acta	PROPN
admet-292	952	2	673	673	NUM
admet-292	952	3	(	(	PUNCT
admet-292	952	4	2010	2010	NUM
admet-292	952	5	)	)	PUNCT
admet-292	952	6	40–46	40–46	NUM
admet-292	952	7	.	.	PUNCT
admet-292	953	1	[	[	X
admet-292	953	2	42	42	NUM
admet-292	953	3	]	]	PUNCT
admet-292	953	4	a.	a.	NOUN
admet-292	953	5	avdeef	avdeef	PROPN
admet-292	953	6	.	.	PUNCT
admet-292	954	1	pharm	pharm	PROPN
admet-292	954	2	.	.	PUNCT
admet-292	955	1	pharmacol	pharmacol	PROPN
admet-292	955	2	.	.	PUNCT
admet-292	956	1	commun	commun	PROPN
admet-292	956	2	.	.	PUNCT
admet-292	957	1	4	4	NUM
admet-292	957	2	(	(	PUNCT
admet-292	957	3	1998	1998	NUM
admet-292	957	4	)	)	PUNCT
admet-292	957	5	165	165	NUM
admet-292	957	6	-	-	SYM
admet-292	957	7	178	178	NUM
admet-292	957	8	.	.	PUNCT
admet-292	958	1	[	[	X
admet-292	958	2	43	43	NUM
admet-292	958	3	]	]	X
admet-292	958	4	w.h	w.h	PROPN
admet-292	958	5	.	.	PROPN
admet-292	958	6	streng	streng	PROPN
admet-292	958	7	.	.	PUNCT
admet-292	959	1	int	int	NOUN
admet-292	959	2	.	.	PUNCT
admet-292	960	1	j.	j.	PROPN
admet-292	960	2	pharm	pharm	PROPN
admet-292	960	3	.	.	PUNCT
admet-292	961	1	186	186	NUM
admet-292	961	2	(	(	PUNCT
admet-292	961	3	1999	1999	NUM
admet-292	961	4	)	)	PUNCT
admet-292	961	5	137	137	NUM
admet-292	961	6	-	-	SYM
admet-292	961	7	140	140	NUM
admet-292	961	8	.	.	PUNCT
admet-292	962	1	[	[	X
admet-292	962	2	44	44	NUM
admet-292	962	3	]	]	PUNCT
admet-292	962	4	z.	z.	PROPN
admet-292	962	5	wang	wang	PROPN
admet-292	962	6	,	,	PUNCT
admet-292	962	7	l.s	l.s	PROPN
admet-292	962	8	.	.	PROPN
admet-292	962	9	burrell	burrell	PROPN
admet-292	962	10	,	,	PUNCT
admet-292	962	11	w.j	w.j	PROPN
admet-292	962	12	.	.	PROPN
admet-292	962	13	lambert	lambert	PROPN
admet-292	962	14	.	.	PUNCT
admet-292	963	1	j.	j.	PROPN
admet-292	963	2	pharm	pharm	PROPN
admet-292	963	3	.	.	PUNCT
admet-292	964	1	sci	sci	PROPN
admet-292	964	2	.	.	PROPN
admet-292	965	1	91	91	NUM
admet-292	965	2	(	(	PUNCT
admet-292	965	3	2002	2002	NUM
admet-292	965	4	)	)	PUNCT
admet-292	965	5	1445	1445	NUM
admet-292	965	6	-	-	SYM
admet-292	965	7	1455	1455	NUM
admet-292	965	8	.	.	PUNCT
admet-292	966	1	[	[	X
admet-292	966	2	45	45	NUM
admet-292	966	3	]	]	PUNCT
admet-292	966	4	a.	a.	NOUN
admet-292	966	5	avdeef	avdeef	PROPN
admet-292	966	6	,	,	PUNCT
admet-292	966	7	j.j	j.j	PROPN
admet-292	966	8	.	.	PROPN
admet-292	966	9	bucher	bucher	PROPN
admet-292	966	10	.	.	PUNCT
admet-292	967	1	anal	anal	PROPN
admet-292	967	2	.	.	PUNCT
admet-292	967	3	chem	chem	PROPN
admet-292	967	4	.	.	PUNCT
admet-292	968	1	50	50	NUM
admet-292	968	2	(	(	PUNCT
admet-292	968	3	1978	1978	NUM
admet-292	968	4	)	)	PUNCT
admet-292	968	5	2137	2137	NUM
admet-292	968	6	-	-	SYM
admet-292	968	7	2142	2142	NUM
admet-292	968	8	.	.	PUNCT
admet-292	969	1	[	[	X
admet-292	969	2	46	46	NUM
admet-292	969	3	]	]	X
admet-292	969	4	a.	a.	NOUN
admet-292	969	5	avdeef	avdeef	PROPN
admet-292	969	6	,	,	PUNCT
admet-292	969	7	c.m	c.m	PROPN
admet-292	969	8	.	.	PROPN
admet-292	969	9	berger	berger	PROPN
admet-292	969	10	,	,	PUNCT
admet-292	969	11	c.	c.	PROPN
admet-292	969	12	brownell	brownell	PROPN
admet-292	969	13	.	.	PUNCT
admet-292	970	1	pharm	pharm	PROPN
admet-292	970	2	.	.	PUNCT
admet-292	971	1	res	re	NOUN
admet-292	971	2	.	.	PROPN
admet-292	972	1	17	17	NUM
admet-292	972	2	(	(	PUNCT
admet-292	972	3	2000	2000	NUM
admet-292	972	4	)	)	PUNCT
admet-292	972	5	85	85	NUM
admet-292	972	6	-	-	SYM
admet-292	972	7	89	89	NUM
admet-292	972	8	.	.	PUNCT
admet-292	973	1	[	[	X
admet-292	973	2	47	47	NUM
admet-292	973	3	]	]	X
admet-292	973	4	j.c	j.c	PROPN
admet-292	973	5	.	.	PROPN
admet-292	973	6	machado	machado	PROPN
admet-292	973	7	,	,	PUNCT
admet-292	973	8	a.d	a.d	PROPN
admet-292	973	9	.	.	PROPN
admet-292	973	10	lange	lange	PROPN
admet-292	973	11	,	,	PUNCT
admet-292	973	12	v.	v.	PROPN
admet-292	973	13	todeschini	todeschini	PROPN
admet-292	973	14	,	,	PUNCT
admet-292	973	15	n.m	n.m	PROPN
admet-292	973	16	.	.	PROPN
admet-292	973	17	volpato	volpato	PROPN
admet-292	973	18	.	.	PUNCT
admet-292	974	1	aaps	aap	NOUN
admet-292	974	2	pharmscitech	pharmscitech	VERB
admet-292	974	3	15	15	NUM
admet-292	974	4	(	(	PUNCT
admet-292	974	5	2014	2014	NUM
admet-292	974	6	)	)	PUNCT
admet-292	974	7	189	189	NUM
admet-292	974	8	-	-	SYM
admet-292	974	9	197	197	NUM
admet-292	974	10	.	.	PUNCT
admet-292	975	1	[	[	X
admet-292	975	2	48	48	NUM
admet-292	975	3	]	]	PUNCT
admet-292	975	4	d.	d.	PROPN
admet-292	975	5	schönherr	schönherr	PROPN
admet-292	975	6	,	,	PUNCT
admet-292	975	7	u.	u.	PROPN
admet-292	975	8	wollatz	wollatz	PROPN
admet-292	975	9	,	,	PUNCT
admet-292	975	10	d.	d.	PROPN
admet-292	975	11	haznar	haznar	PROPN
admet-292	975	12	-	-	PUNCT
admet-292	975	13	garbacz	garbacz	NOUN
admet-292	975	14	,	,	PUNCT
admet-292	975	15	u.	u.	PROPN
admet-292	975	16	hanke	hanke	PROPN
admet-292	975	17	,	,	PUNCT
admet-292	975	18	k.j	k.j	PROPN
admet-292	975	19	.	.	PROPN
admet-292	975	20	box	box	PROPN
admet-292	975	21	,	,	PUNCT
admet-292	975	22	r.	r.	PROPN
admet-292	975	23	taylor	taylor	PROPN
admet-292	975	24	,	,	PUNCT
admet-292	975	25	r.	r.	PROPN
admet-292	975	26	ruiz	ruiz	PROPN
admet-292	975	27	,	,	PUNCT
admet-292	975	28	s.	s.	PROPN
admet-292	975	29	beato	beato	PROPN
admet-292	975	30	,	,	PUNCT
admet-292	975	31	d.	d.	PROPN
admet-292	975	32	becker	becker	PROPN
admet-292	975	33	,	,	PUNCT
admet-292	975	34	w.	w.	PROPN
admet-292	975	35	weitschies	weitschie	NOUN
admet-292	975	36	.	.	PUNCT
admet-292	976	1	eur	eur	PROPN
admet-292	976	2	.	.	PUNCT
admet-292	977	1	j.	j.	PROPN
admet-292	977	2	pharm	pharm	PROPN
admet-292	977	3	.	.	PUNCT
admet-292	978	1	biopharm	biopharm	PROPN
admet-292	978	2	.	.	PUNCT
admet-292	979	1	92	92	NUM
admet-292	979	2	(	(	PUNCT
admet-292	979	3	2015	2015	NUM
admet-292	979	4	)	)	PUNCT
admet-292	979	5	155–170	155–170	NUM
admet-292	979	6	.	.	PUNCT
admet-292	980	1	[	[	X
admet-292	980	2	49	49	NUM
admet-292	980	3	]	]	X
admet-292	980	4	h.a	h.a	PROPN
admet-292	980	5	.	.	PROPN
admet-292	980	6	krebs	krebs	PROPN
admet-292	980	7	,	,	PUNCT
admet-292	980	8	j.c	j.c	PROPN
admet-292	980	9	.	.	PROPN
admet-292	980	10	speakman	speakman	PROPN
admet-292	980	11	.	.	PUNCT
admet-292	981	1	j.	j.	PROPN
admet-292	981	2	chem	chem	PROPN
admet-292	981	3	.	.	PUNCT
admet-292	982	1	soc	soc	PROPN
admet-292	982	2	.	.	PUNCT
admet-292	983	1	(	(	PUNCT
admet-292	983	2	1945	1945	NUM
admet-292	983	3	)	)	PUNCT
admet-292	983	4	593	593	NUM
admet-292	983	5	-	-	SYM
admet-292	983	6	595	595	NUM
admet-292	983	7	.	.	PUNCT
admet-292	984	1	[	[	X
admet-292	984	2	50	50	NUM
admet-292	984	3	]	]	PUNCT
admet-292	984	4	i.	i.	PROPN
admet-292	984	5	zimmermann	zimmermann	PROPN
admet-292	984	6	.	.	PUNCT
admet-292	985	1	int	int	PROPN
admet-292	985	2	.	.	PUNCT
admet-292	986	1	j.	j.	PROPN
admet-292	986	2	pharm	pharm	PROPN
admet-292	986	3	.	.	PUNCT
admet-292	987	1	13	13	NUM
admet-292	987	2	(	(	PUNCT
admet-292	987	3	1983	1983	NUM
admet-292	987	4	)	)	PUNCT
admet-292	987	5	57	57	NUM
admet-292	987	6	-	-	SYM
admet-292	987	7	65	65	NUM
admet-292	987	8	.	.	PUNCT
admet-292	988	1	[	[	X
admet-292	988	2	51	51	NUM
admet-292	988	3	]	]	X
admet-292	988	4	d.l	d.l	PROPN
admet-292	988	5	.	.	PROPN
admet-292	988	6	ross	ross	PROPN
admet-292	988	7	,	,	PUNCT
admet-292	988	8	c.m	c.m	PROPN
admet-292	988	9	.	.	PROPN
admet-292	988	10	riley	riley	PROPN
admet-292	988	11	.	.	PUNCT
admet-292	989	1	int	int	PROPN
admet-292	989	2	.	.	PUNCT
admet-292	990	1	j.	j.	PROPN
admet-292	990	2	pharm	pharm	PROPN
admet-292	990	3	.	.	PUNCT
admet-292	991	1	63	63	NUM
admet-292	991	2	(	(	PUNCT
admet-292	991	3	1990	1990	NUM
admet-292	991	4	)	)	PUNCT
admet-292	991	5	237	237	NUM
admet-292	991	6	-	-	SYM
admet-292	991	7	250	250	NUM
admet-292	991	8	.	.	PUNCT
admet-292	992	1	[	[	X
admet-292	992	2	52	52	NUM
admet-292	992	3	]	]	PUNCT
admet-292	992	4	a.	a.	NOUN
admet-292	992	5	tsuji	tsuji	PROPN
admet-292	992	6	,	,	PUNCT
admet-292	992	7	e.	e.	PROPN
admet-292	992	8	nakashima	nakashima	PROPN
admet-292	992	9	,	,	PUNCT
admet-292	992	10	s.	s.	PROPN
admet-292	992	11	hamano	hamano	PROPN
admet-292	992	12	,	,	PUNCT
admet-292	992	13	t.	t.	PROPN
admet-292	992	14	yamana	yamana	PROPN
admet-292	992	15	.	.	PUNCT
admet-292	993	1	j.	j.	PROPN
admet-292	993	2	pharm	pharm	PROPN
admet-292	993	3	.	.	PUNCT
admet-292	994	1	sci	sci	PROPN
admet-292	994	2	.	.	PROPN
admet-292	995	1	67	67	NUM
admet-292	995	2	(	(	PUNCT
admet-292	995	3	1978	1978	NUM
admet-292	995	4	)	)	PUNCT
admet-292	995	5	1059	1059	NUM
admet-292	995	6	-	-	SYM
admet-292	995	7	1066	1066	NUM
admet-292	995	8	.	.	PUNCT
admet-292	996	1	[	[	X
admet-292	996	2	53	53	NUM
admet-292	996	3	]	]	PUNCT
admet-292	996	4	e.	e.	PROPN
admet-292	996	5	shoghi	shoghi	PROPN
admet-292	996	6	,	,	PUNCT
admet-292	996	7	e.	e.	PROPN
admet-292	996	8	fuguet	fuguet	PROPN
admet-292	996	9	,	,	PUNCT
admet-292	996	10	e.	e.	PROPN
admet-292	996	11	bosch	bosch	PROPN
admet-292	996	12	,	,	PUNCT
admet-292	996	13	c.	c.	PROPN
admet-292	996	14	ràfols	ràfol	NOUN
admet-292	996	15	.	.	PUNCT
admet-292	997	1	eur	eur	PROPN
admet-292	997	2	.	.	PUNCT
admet-292	998	1	j.	j.	PROPN
admet-292	998	2	pharm	pharm	PROPN
admet-292	998	3	.	.	PUNCT
admet-292	999	1	sci	sci	PROPN
admet-292	999	2	.	.	PROPN
admet-292	1000	1	48	48	NUM
admet-292	1000	2	(	(	PUNCT
admet-292	1000	3	2012	2012	NUM
admet-292	1000	4	)	)	PUNCT
admet-292	1000	5	290	290	NUM
admet-292	1000	6	-	-	SYM
admet-292	1000	7	300	300	NUM
admet-292	1000	8	.	.	PUNCT
admet-292	1001	1	[	[	X
admet-292	1001	2	54	54	NUM
admet-292	1001	3	]	]	SYM
admet-292	1001	4	t.m	t.m	PROPN
admet-292	1001	5	.	.	PROPN
admet-292	1001	6	ward	ward	PROPN
admet-292	1001	7	,	,	PUNCT
admet-292	1001	8	j.b	j.b	PROPN
admet-292	1001	9	.	.	PUNCT
admet-292	1001	10	weber	weber	PROPN
admet-292	1001	11	.	.	PUNCT
admet-292	1002	1	j.	j.	PROPN
admet-292	1002	2	agr	agr	PROPN
admet-292	1002	3	.	.	PUNCT
admet-292	1002	4	food	food	NOUN
admet-292	1002	5	chem	chem	NOUN
admet-292	1002	6	.	.	PUNCT
admet-292	1003	1	16	16	NUM
admet-292	1003	2	(	(	PUNCT
admet-292	1003	3	1968	1968	NUM
admet-292	1003	4	)	)	PUNCT
admet-292	1003	5	959	959	NUM
admet-292	1003	6	-	-	SYM
admet-292	1003	7	961	961	NUM
admet-292	1003	8	.	.	PUNCT
admet-292	1004	1	[	[	X
admet-292	1004	2	55	55	NUM
admet-292	1004	3	]	]	X
admet-292	1004	4	j.b	j.b	PROPN
admet-292	1004	5	.	.	PUNCT
admet-292	1004	6	weber	weber	PROPN
admet-292	1004	7	.	.	PUNCT
admet-292	1004	8	spectrochim	spectrochim	PROPN
admet-292	1004	9	.	.	PUNCT
admet-292	1005	1	acta	acta	PROPN
admet-292	1005	2	23	23	NUM
admet-292	1005	3	(	(	PUNCT
admet-292	1005	4	1967	1967	NUM
admet-292	1005	5	)	)	PUNCT
admet-292	1005	6	458	458	NUM
admet-292	1005	7	-	-	SYM
admet-292	1005	8	461	461	NUM
admet-292	1005	9	.	.	PUNCT
admet-292	1006	1	[	[	X
admet-292	1006	2	56	56	NUM
admet-292	1006	3	]	]	X
admet-292	1006	4	s.	s.	PROPN
admet-292	1006	5	li	li	PROPN
admet-292	1006	6	,	,	PUNCT
admet-292	1006	7	s.	s.	PROPN
admet-292	1006	8	wong	wong	PROPN
admet-292	1006	9	,	,	PUNCT
admet-292	1006	10	s.	s.	PROPN
admet-292	1006	11	sethia	sethia	PROPN
admet-292	1006	12	,	,	PUNCT
admet-292	1006	13	h.	h.	PROPN
admet-292	1006	14	almoazen	almoazen	PROPN
admet-292	1006	15	,	,	PUNCT
admet-292	1006	16	y.m	y.m	PROPN
admet-292	1006	17	.	.	PROPN
admet-292	1006	18	joshi	joshi	PROPN
admet-292	1006	19	,	,	PUNCT
admet-292	1006	20	a.t.m	a.t.m	PROPN
admet-292	1006	21	.	.	PUNCT
admet-292	1006	22	serajuddin	serajuddin	PROPN
admet-292	1006	23	.	.	PUNCT
admet-292	1007	1	pharm	pharm	PROPN
admet-292	1007	2	.	.	PUNCT
admet-292	1008	1	res	re	NOUN
admet-292	1008	2	.	.	PUNCT
admet-292	1009	1	22	22	NUM
admet-292	1009	2	(	(	PUNCT
admet-292	1009	3	2005	2005	NUM
admet-292	1009	4	)	)	PUNCT
admet-292	1009	5	628	628	NUM
admet-292	1009	6	-	-	SYM
admet-292	1009	7	635	635	NUM
admet-292	1009	8	.	.	PUNCT
admet-292	1010	1	[	[	X
admet-292	1010	2	57	57	NUM
admet-292	1010	3	]	]	PUNCT
admet-292	1010	4	s.	s.	PROPN
admet-292	1010	5	li	li	PROPN
admet-292	1010	6	,	,	PUNCT
admet-292	1010	7	p.	p.	PROPN
admet-292	1010	8	doyle	doyle	PROPN
admet-292	1010	9	,	,	PUNCT
admet-292	1010	10	s.	s.	PROPN
admet-292	1010	11	metz	metz	PROPN
admet-292	1010	12	,	,	PUNCT
admet-292	1010	13	a.e	a.e	PROPN
admet-292	1010	14	.	.	PROPN
admet-292	1010	15	royce	royce	PROPN
admet-292	1010	16	,	,	PUNCT
admet-292	1010	17	a.t.m	a.t.m	PROPN
admet-292	1010	18	.	.	PUNCT
admet-292	1011	1	serajuddin	serajuddin	VERB
admet-292	1011	2	j.	j.	PROPN
admet-292	1011	3	pharm	pharm	PROPN
admet-292	1011	4	.	.	PUNCT
admet-292	1012	1	sci	sci	PROPN
admet-292	1012	2	.	.	PROPN
admet-292	1013	1	94	94	NUM
admet-292	1013	2	(	(	PUNCT
admet-292	1013	3	2005	2005	NUM
admet-292	1013	4	)	)	PUNCT
admet-292	1013	5	2224	2224	NUM
admet-292	1013	6	-	-	SYM
admet-292	1013	7	2231	2231	NUM
admet-292	1013	8	.	.	PUNCT
admet-292	1014	1	[	[	X
admet-292	1014	2	58	58	NUM
admet-292	1014	3	]	]	X
admet-292	1014	4	g.	g.	PROPN
admet-292	1014	5	zografi	zografi	PROPN
admet-292	1014	6	,	,	PUNCT
admet-292	1014	7	i.	i.	PROPN
admet-292	1014	8	zarenda	zarenda	PROPN
admet-292	1014	9	.	.	PUNCT
admet-292	1015	1	biochem	biochem	PROPN
admet-292	1015	2	.	.	PUNCT
admet-292	1016	1	pharmacol	pharmacol	PROPN
admet-292	1016	2	.	.	PROPN
admet-292	1017	1	15	15	NUM
admet-292	1017	2	(	(	PUNCT
admet-292	1017	3	1966	1966	NUM
admet-292	1017	4	)	)	PUNCT
admet-292	1017	5	591	591	NUM
admet-292	1017	6	-	-	SYM
admet-292	1017	7	598	598	NUM
admet-292	1017	8	.	.	PUNCT
admet-292	1018	1	[	[	X
admet-292	1018	2	59	59	NUM
admet-292	1018	3	]	]	X
admet-292	1018	4	a.s	a.s	PROPN
admet-292	1018	5	.	.	PROPN
admet-292	1018	6	indulkar	indulkar	PROPN
admet-292	1018	7	,	,	PUNCT
admet-292	1018	8	k.j	k.j	PROPN
admet-292	1018	9	.	.	PROPN
admet-292	1018	10	box	box	PROPN
admet-292	1018	11	,	,	PUNCT
admet-292	1018	12	r.	r.	PROPN
admet-292	1018	13	taylor	taylor	PROPN
admet-292	1018	14	,	,	PUNCT
admet-292	1018	15	r.	r.	PROPN
admet-292	1018	16	ruiz	ruiz	PROPN
admet-292	1018	17	,	,	PUNCT
admet-292	1018	18	l.s	l.s	PROPN
admet-292	1018	19	.	.	PROPN
admet-292	1018	20	taylor	taylor	PROPN
admet-292	1018	21	.	.	PUNCT
admet-292	1018	22	mol	mol	PROPN
admet-292	1018	23	.	.	PROPN
admet-292	1018	24	pharmaceut	pharmaceut	PROPN
admet-292	1018	25	.	.	PUNCT
admet-292	1019	1	12	12	NUM
admet-292	1019	2	(	(	PUNCT
admet-292	1019	3	2015	2015	NUM
admet-292	1019	4	)	)	PUNCT
admet-292	1019	5	,	,	PUNCT
admet-292	1019	6	2365	2365	NUM
admet-292	1019	7	-	-	SYM
admet-292	1019	8	2377	2377	NUM
admet-292	1019	9	.	.	PUNCT
admet-292	1020	1	[	[	X
admet-292	1020	2	60	60	NUM
admet-292	1020	3	]	]	PUNCT
admet-292	1020	4	a.	a.	NOUN
admet-292	1020	5	avdeef	avdeef	PROPN
admet-292	1020	6	,	,	PUNCT
admet-292	1020	7	o.	o.	PROPN
admet-292	1020	8	tsinman	tsinman	NOUN
admet-292	1020	9	.	.	PUNCT
admet-292	1021	1	pharm	pharm	PROPN
admet-292	1021	2	.	.	PUNCT
admet-292	1022	1	res	re	NOUN
admet-292	1022	2	.	.	PROPN
admet-292	1023	1	25	25	NUM
admet-292	1023	2	(	(	PUNCT
admet-292	1023	3	2008	2008	NUM
admet-292	1023	4	)	)	PUNCT
admet-292	1023	5	2613	2613	NUM
admet-292	1023	6	-	-	SYM
admet-292	1023	7	2627	2627	NUM
admet-292	1023	8	.	.	PUNCT
admet-292	1024	1	[	[	X
admet-292	1024	2	61	61	NUM
admet-292	1024	3	]	]	X
admet-292	1024	4	c.	c.	PROPN
admet-292	1024	5	dagenais	dagenais	PROPN
admet-292	1024	6	,	,	PUNCT
admet-292	1024	7	a.	a.	NOUN
admet-292	1024	8	avdeef	avdeef	PROPN
admet-292	1024	9	,	,	PUNCT
admet-292	1024	10	o.	o.	PROPN
admet-292	1024	11	tsinman	tsinman	NOUN
admet-292	1024	12	,	,	PUNCT
admet-292	1024	13	a.	a.	PROPN
admet-292	1024	14	dudley	dudley	PROPN
admet-292	1024	15	,	,	PUNCT
admet-292	1024	16	r.	r.	PROPN
admet-292	1024	17	beliveau	beliveau	PROPN
admet-292	1024	18	.	.	PUNCT
admet-292	1025	1	eur	eur	PROPN
admet-292	1025	2	.	.	PUNCT
admet-292	1026	1	j.	j.	PROPN
admet-292	1026	2	pharm	pharm	PROPN
admet-292	1026	3	.	.	PUNCT
admet-292	1027	1	sci	sci	PROPN
admet-292	1027	2	.	.	PROPN
admet-292	1028	1	38	38	NUM
admet-292	1028	2	(	(	PUNCT
admet-292	1028	3	2009	2009	NUM
admet-292	1028	4	)	)	PUNCT
admet-292	1028	5	121	121	NUM
admet-292	1028	6	-	-	SYM
admet-292	1028	7	137	137	NUM
admet-292	1028	8	.	.	PUNCT
admet-292	1029	1	[	[	X
admet-292	1029	2	62	62	NUM
admet-292	1029	3	]	]	PUNCT
admet-292	1029	4	s.-t	s.-t	NOUN
admet-292	1029	5	.	.	PUNCT
admet-292	1030	1	liu	liu	PROPN
admet-292	1030	2	,	,	PUNCT
admet-292	1030	3	a.	a.	PROPN
admet-292	1030	4	hurwitz	hurwitz	PROPN
admet-292	1030	5	.	.	PUNCT
admet-292	1031	1	j.	j.	PROPN
admet-292	1031	2	colloid	colloid	PROPN
admet-292	1031	3	int	int	PROPN
admet-292	1031	4	.	.	PUNCT
admet-292	1032	1	sci	sci	PROPN
admet-292	1032	2	.	.	PROPN
admet-292	1033	1	60	60	NUM
admet-292	1033	2	(	(	PUNCT
admet-292	1033	3	1977	1977	NUM
admet-292	1033	4	)	)	PUNCT
admet-292	1033	5	410	410	NUM
admet-292	1033	6	-	-	SYM
admet-292	1033	7	413	413	NUM
admet-292	1033	8	.	.	PUNCT
admet-292	1034	1	[	[	X
admet-292	1034	2	63	63	NUM
admet-292	1034	3	]	]	PUNCT
admet-292	1034	4	k.	k.	PROPN
admet-292	1034	5	takács	takács	PROPN
admet-292	1034	6	-	-	PUNCT
admet-292	1034	7	novák	novák	PROPN
admet-292	1034	8	,	,	PUNCT
admet-292	1034	9	g.	g.	PROPN
admet-292	1034	10	völgyi	völgyi	PROPN
admet-292	1034	11	.	.	PUNCT
admet-292	1035	1	best	good	ADJ
admet-292	1035	2	practice	practice	NOUN
admet-292	1035	3	for	for	ADP
admet-292	1035	4	saturation	saturation	NOUN
admet-292	1035	5	shake	shake	NOUN
admet-292	1035	6	-	-	PUNCT
admet-292	1035	7	flask	flask	NOUN
admet-292	1035	8	measurements	measurement	NOUN
admet-292	1035	9	of	of	ADP
admet-292	1035	10	thermodynamic	thermodynamic	ADJ
admet-292	1035	11	solubility	solubility	NOUN
admet-292	1035	12	.	.	PUNCT
admet-292	1036	1	abstracts	abstract	NOUN
admet-292	1036	2	–	–	PUNCT
admet-292	1036	3	4th	4th	ADJ
admet-292	1036	4	world	world	NOUN
admet-292	1036	5	conf	conf	NOUN
admet-292	1036	6	.	.	PUNCT
admet-292	1037	1	phys.-chem	phys.-chem	PROPN
admet-292	1037	2	.	.	PUNCT
admet-292	1038	1	meth	meth	NOUN
admet-292	1038	2	.	.	PUNCT
admet-292	1039	1	drug	drug	NOUN
admet-292	1039	2	disc	disc	NOUN
admet-292	1039	3	.	.	PUNCT
admet-292	1040	1	dev	dev	PROPN
admet-292	1040	2	.	.	PROPN
admet-292	1040	3	,	,	PUNCT
admet-292	1040	4	red	red	PROPN
admet-292	1040	5	island	island	NOUN
admet-292	1040	6	,	,	PUNCT
admet-292	1040	7	croatia	croatia	PROPN
admet-292	1040	8	,	,	PUNCT
admet-292	1040	9	21	21	NUM
admet-292	1040	10	-	-	SYM
admet-292	1040	11	24	24	NUM
admet-292	1040	12	sep	sep	PROPN
admet-292	1040	13	2015	2015	NUM
admet-292	1040	14	.	.	PUNCT
admet-292	1041	1	[	[	X
admet-292	1041	2	64	64	NUM
admet-292	1041	3	]	]	PUNCT
admet-292	1041	4	m.	m.	PROPN
admet-292	1041	5	stuart	stuart	PROPN
admet-292	1041	6	,	,	PUNCT
admet-292	1041	7	k.	k.	PROPN
admet-292	1041	8	box	box	PROPN
admet-292	1041	9	.	.	PUNCT
admet-292	1042	1	anal	anal	PROPN
admet-292	1042	2	.	.	PUNCT
admet-292	1042	3	chem	chem	PROPN
admet-292	1042	4	.	.	PUNCT
admet-292	1043	1	77	77	NUM
admet-292	1043	2	(	(	PUNCT
admet-292	1043	3	2005	2005	NUM
admet-292	1043	4	)	)	PUNCT
admet-292	1043	5	983	983	NUM
admet-292	1043	6	-	-	SYM
admet-292	1043	7	990	990	NUM
admet-292	1043	8	.	.	PUNCT
admet-292	1044	1	[	[	X
admet-292	1044	2	65	65	NUM
admet-292	1044	3	]	]	X
admet-292	1044	4	k.j	k.j	PROPN
admet-292	1044	5	.	.	PROPN
admet-292	1044	6	box	box	PROPN
admet-292	1044	7	,	,	PUNCT
admet-292	1044	8	g.	g.	PROPN
admet-292	1044	9	völgyi	völgyi	PROPN
admet-292	1044	10	,	,	PUNCT
admet-292	1044	11	e.	e.	PROPN
admet-292	1044	12	baka	baka	PROPN
admet-292	1044	13	,	,	PUNCT
admet-292	1044	14	m.	m.	PROPN
admet-292	1044	15	stuart	stuart	PROPN
admet-292	1044	16	,	,	PUNCT
admet-292	1044	17	k.	k.	PROPN
admet-292	1044	18	takács	takács	PROPN
admet-292	1044	19	-	-	PUNCT
admet-292	1044	20	novák	novák	PROPN
admet-292	1044	21	,	,	PUNCT
admet-292	1044	22	j.e	j.e	PROPN
admet-292	1044	23	.	.	PROPN
admet-292	1044	24	comer	comer	PROPN
admet-292	1044	25	.	.	PUNCT
admet-292	1045	1	j.	j.	PROPN
admet-292	1045	2	pharm	pharm	PROPN
admet-292	1045	3	.	.	PUNCT
admet-292	1046	1	sci	sci	PROPN
admet-292	1046	2	.	.	PROPN
admet-292	1047	1	95	95	NUM
admet-292	1047	2	(	(	PUNCT
admet-292	1047	3	6	6	NUM
admet-292	1047	4	)	)	PUNCT
admet-292	1047	5	(	(	PUNCT
admet-292	1047	6	2006	2006	NUM
admet-292	1047	7	)	)	PUNCT
admet-292	1047	8	12981307	12981307	NUM
admet-292	1047	9	.	.	PUNCT
admet-292	1048	1	[	[	X
admet-292	1048	2	66	66	NUM
admet-292	1048	3	]	]	PUNCT
admet-292	1048	4	a.	a.	NOUN
admet-292	1048	5	llinàs	llinàs	PROPN
admet-292	1048	6	,	,	PUNCT
admet-292	1048	7	j.c	j.c	PROPN
admet-292	1048	8	.	.	PROPN
admet-292	1048	9	burley	burley	PROPN
admet-292	1048	10	,	,	PUNCT
admet-292	1048	11	k.j	k.j	PROPN
admet-292	1048	12	.	.	PROPN
admet-292	1048	13	box	box	PROPN
admet-292	1048	14	,	,	PUNCT
admet-292	1048	15	r.c	r.c	PROPN
admet-292	1048	16	.	.	PROPN
admet-292	1048	17	glen	glen	PROPN
admet-292	1048	18	,	,	PUNCT
admet-292	1048	19	j.m	j.m	PROPN
admet-292	1048	20	.	.	PROPN
admet-292	1048	21	goodman	goodman	PROPN
admet-292	1048	22	.	.	PUNCT
admet-292	1049	1	j.	j.	PROPN
admet-292	1049	2	med	med	PROPN
admet-292	1049	3	.	.	PROPN
admet-292	1049	4	chem	chem	PROPN
admet-292	1049	5	.	.	PUNCT
admet-292	1050	1	50	50	NUM
admet-292	1050	2	(	(	PUNCT
admet-292	1050	3	2007	2007	NUM
admet-292	1050	4	)	)	PUNCT
admet-292	1050	5	979	979	NUM
admet-292	1050	6	-	-	SYM
admet-292	1050	7	983	983	NUM
admet-292	1050	8	.	.	PUNCT
admet-292	1051	1	[	[	X
admet-292	1051	2	67	67	NUM
admet-292	1051	3	]	]	PUNCT
admet-292	1051	4	m.	m.	NOUN
admet-292	1051	5	yasuda	yasuda	PROPN
admet-292	1051	6	.	.	PUNCT
admet-292	1052	1	bull	bull	PROPN
admet-292	1052	2	.	.	PUNCT
admet-292	1053	1	chem	chem	PROPN
admet-292	1053	2	.	.	PUNCT
admet-292	1054	1	soc	soc	PROPN
admet-292	1054	2	.	.	PUNCT
admet-292	1055	1	jpn	jpn	PROPN
admet-292	1055	2	.	.	PROPN
admet-292	1055	3	32	32	NUM
admet-292	1055	4	(	(	PUNCT
admet-292	1055	5	1959	1959	NUM
admet-292	1055	6	)	)	PUNCT
admet-292	1055	7	429	429	NUM
admet-292	1055	8	-	-	SYM
admet-292	1055	9	432	432	NUM
admet-292	1055	10	.	.	PUNCT
admet-292	1056	1	[	[	X
admet-292	1056	2	68	68	NUM
admet-292	1056	3	]	]	PUNCT
admet-292	1056	4	t.	t.	NOUN
admet-292	1056	5	shedlovsky	shedlovsky	NOUN
admet-292	1056	6	.	.	PUNCT
admet-292	1057	1	electrolytes	electrolyte	NOUN
admet-292	1057	2	,	,	PUNCT
admet-292	1057	3	proc	proc	NOUN
admet-292	1057	4	.	.	PUNCT
admet-292	1058	1	intern	intern	PROPN
admet-292	1058	2	.	.	PUNCT
admet-292	1058	3	symp	symp	PROPN
admet-292	1058	4	.	.	PUNCT
admet-292	1058	5	,	,	PUNCT
admet-292	1058	6	trieste	trieste	PROPN
admet-292	1058	7	,	,	PUNCT
admet-292	1058	8	italy	italy	PROPN
admet-292	1058	9	,	,	PUNCT
admet-292	1058	10	1962	1962	NUM
admet-292	1058	11	,	,	PUNCT
admet-292	1058	12	1959	1959	NUM
admet-292	1058	13	,	,	PUNCT
admet-292	1058	14	146	146	NUM
admet-292	1058	15	-	-	SYM
admet-292	1058	16	151	151	NUM
admet-292	1058	17	.	.	PUNCT
admet-292	1059	1	admet	admet	PROPN
admet-292	1059	2	&	&	CCONJ
admet-292	1059	3	dmpk	dmpk	PROPN
admet-292	1059	4	4(2	4(2	NUM
admet-292	1059	5	)	)	PUNCT
admet-292	1059	6	(	(	PUNCT
admet-292	1059	7	2016	2016	NUM
admet-292	1059	8	)	)	PUNCT
admet-292	1059	9	117	117	NUM
admet-292	1059	10	-	-	SYM
admet-292	1059	11	178	178	NUM
admet-292	1059	12	consensus	consensus	NOUN
admet-292	1059	13	recommendations	recommendation	NOUN
admet-292	1059	14	for	for	ADP
admet-292	1059	15	improving	improve	VERB
admet-292	1059	16	solubility	solubility	NOUN
admet-292	1059	17	-	-	PUNCT
admet-292	1059	18	ph	ph	ADJ
admet-292	1059	19	data	datum	NOUN
admet-292	1059	20	quality	quality	NOUN
admet-292	1059	21	doi	doi	NOUN
admet-292	1059	22	:	:	PUNCT
admet-292	1059	23	10.5599	10.5599	NUM
admet-292	1059	24	/	/	SYM
admet-292	1059	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1059	26	159	159	NUM
admet-292	1059	27	[	[	X
admet-292	1059	28	69	69	NUM
admet-292	1059	29	]	]	PUNCT
admet-292	1059	30	t.	t.	NOUN
admet-292	1059	31	shedlovsky	shedlovsky	NOUN
admet-292	1059	32	.	.	PUNCT
admet-292	1060	1	in	in	ADP
admet-292	1060	2	pesce	pesce	PROPN
admet-292	1060	3	,	,	PUNCT
admet-292	1060	4	b.	b.	PROPN
admet-292	1060	5	in	in	ADP
admet-292	1060	6	electrolytes	electrolyte	NOUN
admet-292	1060	7	.	.	PUNCT
admet-292	1061	1	ed	ed	NOUN
admet-292	1061	2	.	.	PUNCT
admet-292	1061	3	;	;	PUNCT
admet-292	1061	4	pergamon	pergamon	PROPN
admet-292	1061	5	press	press	PROPN
admet-292	1061	6	:	:	PUNCT
admet-292	1061	7	new	new	PROPN
admet-292	1061	8	york	york	PROPN
admet-292	1061	9	,	,	PUNCT
admet-292	1061	10	1962	1962	NUM
admet-292	1061	11	;	;	PUNCT
admet-292	1061	12	pp	pp	X
admet-292	1061	13	.	.	PUNCT
admet-292	1062	1	146	146	NUM
admet-292	1062	2	-	-	SYM
admet-292	1062	3	151	151	NUM
admet-292	1062	4	.	.	PUNCT
admet-292	1063	1	[	[	X
admet-292	1063	2	70	70	NUM
admet-292	1063	3	]	]	X
admet-292	1063	4	d.	d.	PROPN
admet-292	1063	5	kovala	kovala	PROPN
admet-292	1063	6	-	-	PUNCT
admet-292	1063	7	demertzi	demertzi	PROPN
admet-292	1063	8	,	,	PUNCT
admet-292	1063	9	d.	d.	PROPN
admet-292	1063	10	mentzafos	mentzafos	PROPN
admet-292	1063	11	,	,	PUNCT
admet-292	1063	12	a.	a.	NOUN
admet-292	1063	13	terzis	terzi	NOUN
admet-292	1063	14	.	.	PUNCT
admet-292	1064	1	polyhedron	polyhedron	NOUN
admet-292	1064	2	12	12	NUM
admet-292	1064	3	(	(	PUNCT
admet-292	1064	4	1993	1993	NUM
admet-292	1064	5	)	)	PUNCT
admet-292	1064	6	1361	1361	NUM
admet-292	1064	7	-	-	SYM
admet-292	1064	8	1370	1370	NUM
admet-292	1064	9	.	.	PUNCT
admet-292	1065	1	[	[	X
admet-292	1065	2	71	71	NUM
admet-292	1065	3	]	]	PUNCT
admet-292	1065	4	a.	a.	NOUN
admet-292	1065	5	llinàs	llinàs	PROPN
admet-292	1065	6	,	,	PUNCT
admet-292	1065	7	j.m	j.m	PROPN
admet-292	1065	8	.	.	PROPN
admet-292	1065	9	goodman	goodman	PROPN
admet-292	1065	10	.	.	PUNCT
admet-292	1066	1	drug	drug	NOUN
admet-292	1066	2	discov	discov	PROPN
admet-292	1066	3	.	.	PUNCT
admet-292	1067	1	today	today	NOUN
admet-292	1067	2	13	13	NUM
admet-292	1067	3	(	(	PUNCT
admet-292	1067	4	2008	2008	NUM
admet-292	1067	5	)	)	PUNCT
admet-292	1067	6	198	198	NUM
admet-292	1067	7	-	-	SYM
admet-292	1067	8	210	210	NUM
admet-292	1067	9	.	.	PUNCT
admet-292	1068	1	[	[	X
admet-292	1068	2	72	72	NUM
admet-292	1068	3	]	]	PUNCT
admet-292	1068	4	a.	a.	NOUN
admet-292	1068	5	llinàs	llinàs	PROPN
admet-292	1068	6	,	,	PUNCT
admet-292	1068	7	l.	l.	PROPN
admet-292	1068	8	fábián	fábián	PROPN
admet-292	1068	9	,	,	PUNCT
admet-292	1068	10	j.c	j.c	PROPN
admet-292	1068	11	.	.	PROPN
admet-292	1068	12	burley	burley	PROPN
admet-292	1068	13	,	,	PUNCT
admet-292	1068	14	j.	j.	PROPN
admet-292	1068	15	van	van	PROPN
admet-292	1068	16	de	de	PROPN
admet-292	1068	17	streek	streek	PROPN
admet-292	1068	18	,	,	PUNCT
admet-292	1068	19	j.m	j.m	PROPN
admet-292	1068	20	.	.	PROPN
admet-292	1068	21	goodman	goodman	PROPN
admet-292	1068	22	.	.	PUNCT
admet-292	1069	1	acta	acta	PROPN
admet-292	1069	2	cryst	cryst	PROPN
admet-292	1069	3	.	.	PUNCT
admet-292	1070	1	e62	e62	NOUN
admet-292	1070	2	(	(	PUNCT
admet-292	1070	3	2006	2006	NUM
admet-292	1070	4	)	)	PUNCT
admet-292	1070	5	o4196	o4196	NOUN
admet-292	1070	6	-	-	PUNCT
admet-292	1070	7	o4199	o4199	PROPN
admet-292	1070	8	[	[	X
admet-292	1070	9	73	73	NUM
admet-292	1070	10	]	]	PUNCT
admet-292	1070	11	a.	a.	NOUN
admet-292	1070	12	llinàs	llinàs	PROPN
admet-292	1070	13	,	,	PUNCT
admet-292	1070	14	k.j	k.j	PROPN
admet-292	1070	15	.	.	PROPN
admet-292	1070	16	box	box	PROPN
admet-292	1070	17	,	,	PUNCT
admet-292	1070	18	j.	j.	PROPN
admet-292	1070	19	c.	c.	PROPN
admet-292	1070	20	burley	burley	PROPN
admet-292	1070	21	,	,	PUNCT
admet-292	1070	22	r.	r.	PROPN
admet-292	1070	23	c.	c.	PROPN
admet-292	1070	24	glen	glen	PROPN
admet-292	1070	25	,	,	PUNCT
admet-292	1070	26	j.	j.	PROPN
admet-292	1070	27	m.	m.	PROPN
admet-292	1070	28	goodman	goodman	PROPN
admet-292	1070	29	.	.	PUNCT
admet-292	1071	1	j.	j.	PROPN
admet-292	1071	2	appl	appl	PROPN
admet-292	1071	3	.	.	PUNCT
admet-292	1072	1	cryst	cryst	PROPN
admet-292	1072	2	.	.	PUNCT
admet-292	1073	1	40	40	NUM
admet-292	1073	2	(	(	PUNCT
admet-292	1073	3	2007	2007	NUM
admet-292	1073	4	)	)	PUNCT
admet-292	1073	5	379	379	NUM
admet-292	1073	6	-	-	SYM
admet-292	1073	7	381	381	NUM
admet-292	1073	8	.	.	PUNCT
admet-292	1074	1	[	[	X
admet-292	1074	2	74	74	NUM
admet-292	1074	3	]	]	PUNCT
admet-292	1074	4	a.	a.	PROPN
admet-292	1074	5	f.	f.	PROPN
admet-292	1074	6	fioritto	fioritto	PROPN
admet-292	1074	7	,	,	PUNCT
admet-292	1074	8	s.n	s.n	PROPN
admet-292	1074	9	.	.	PROPN
admet-292	1074	10	bhattachar	bhattachar	PROPN
admet-292	1074	11	,	,	PUNCT
admet-292	1074	12	j.a	j.a	PROPN
admet-292	1074	13	.	.	PROPN
admet-292	1074	14	wesley	wesley	PROPN
admet-292	1074	15	.	.	PUNCT
admet-292	1075	1	int	int	NOUN
admet-292	1075	2	.	.	PUNCT
admet-292	1076	1	j.	j.	PROPN
admet-292	1076	2	pharm	pharm	PROPN
admet-292	1076	3	.	.	PUNCT
admet-292	1077	1	330	330	NUM
admet-292	1077	2	(	(	PUNCT
admet-292	1077	3	2007	2007	NUM
admet-292	1077	4	)	)	PUNCT
admet-292	1077	5	105	105	NUM
admet-292	1077	6	-	-	SYM
admet-292	1077	7	113	113	NUM
admet-292	1077	8	.	.	PUNCT
admet-292	1078	1	[	[	X
admet-292	1078	2	75	75	NUM
admet-292	1078	3	]	]	X
admet-292	1078	4	c.h	c.h	PROPN
admet-292	1078	5	.	.	PROPN
admet-292	1078	6	koo	koo	PROPN
admet-292	1078	7	,	,	PUNCT
admet-292	1078	8	s.h	s.h	PROPN
admet-292	1078	9	.	.	PROPN
admet-292	1078	10	kim	kim	PROPN
admet-292	1078	11	,	,	PUNCT
admet-292	1078	12	w.	w.	PROPN
admet-292	1078	13	shin	shin	PROPN
admet-292	1078	14	.	.	PUNCT
admet-292	1079	1	bull	bull	NOUN
admet-292	1079	2	.	.	PUNCT
admet-292	1080	1	korean	korean	ADJ
admet-292	1080	2	chem	chem	PROPN
admet-292	1080	3	.	.	PUNCT
admet-292	1081	1	soc	soc	PROPN
admet-292	1081	2	.	.	PUNCT
admet-292	1082	1	6	6	NUM
admet-292	1082	2	(	(	PUNCT
admet-292	1082	3	1985	1985	NUM
admet-292	1082	4	)	)	PUNCT
admet-292	1083	1	222–224	222–224	NUM
admet-292	1083	2	.	.	PUNCT
admet-292	1084	1	[	[	X
admet-292	1084	2	76	76	NUM
admet-292	1084	3	]	]	X
admet-292	1084	4	w.	w.	PROPN
admet-292	1084	5	i.	i.	PROPN
admet-292	1084	6	david	david	PROPN
admet-292	1084	7	,	,	PUNCT
admet-292	1084	8	k.	k.	PROPN
admet-292	1084	9	shankland	shankland	PROPN
admet-292	1084	10	,	,	PUNCT
admet-292	1084	11	n.	n.	NOUN
admet-292	1084	12	shankland	shankland	NOUN
admet-292	1084	13	.	.	PUNCT
admet-292	1085	1	chem	chem	PROPN
admet-292	1085	2	.	.	PUNCT
admet-292	1086	1	commun	commun	PROPN
admet-292	1086	2	.	.	PUNCT
admet-292	1087	1	8	8	NUM
admet-292	1087	2	(	(	PUNCT
admet-292	1087	3	1998	1998	NUM
admet-292	1087	4	)	)	PUNCT
admet-292	1087	5	931	931	NUM
admet-292	1087	6	-	-	SYM
admet-292	1087	7	932	932	NUM
admet-292	1087	8	.	.	PUNCT
admet-292	1088	1	[	[	X
admet-292	1088	2	77	77	NUM
admet-292	1088	3	]	]	X
admet-292	1088	4	a.	a.	PROPN
admet-292	1088	5	c.	c.	PROPN
admet-292	1088	6	larson	larson	PROPN
admet-292	1088	7	,	,	PUNCT
admet-292	1088	8	r.	r.	PROPN
admet-292	1088	9	b.	b.	PROPN
admet-292	1088	10	von	von	PROPN
admet-292	1088	11	dreele	dreele	PROPN
admet-292	1088	12	,	,	PUNCT
admet-292	1088	13	r.	r.	PROPN
admet-292	1088	14	b.	b.	PROPN
admet-292	1088	15	general	general	PROPN
admet-292	1088	16	structure	structure	NOUN
admet-292	1088	17	analysis	analysis	NOUN
admet-292	1088	18	system	system	NOUN
admet-292	1088	19	(	(	PUNCT
admet-292	1088	20	gsas	gsa	NOUN
admet-292	1088	21	)	)	PUNCT
admet-292	1088	22	,	,	PUNCT
admet-292	1088	23	report	report	VERB
admet-292	1088	24	laur	laur	PROPN
admet-292	1088	25	86	86	NUM
admet-292	1088	26	-	-	SYM
admet-292	1088	27	748	748	NUM
admet-292	1088	28	.	.	PUNCT
admet-292	1089	1	los	los	PROPN
admet-292	1089	2	alamos	alamos	PROPN
admet-292	1089	3	national	national	PROPN
admet-292	1089	4	laboratory	laboratory	PROPN
admet-292	1089	5	,	,	PUNCT
admet-292	1089	6	new	new	PROPN
admet-292	1089	7	mexico	mexico	PROPN
admet-292	1089	8	,	,	PUNCT
admet-292	1089	9	usa	usa	PROPN
admet-292	1089	10	,	,	PUNCT
admet-292	1089	11	2000	2000	NUM
admet-292	1089	12	.	.	PUNCT
admet-292	1090	1	[	[	X
admet-292	1090	2	78	78	NUM
admet-292	1090	3	]	]	PUNCT
admet-292	1090	4	http://www.panalytical.com/xpert3-powder.htm	http://www.panalytical.com/xpert3-powder.htm	NOUN
admet-292	1090	5	.	.	PUNCT
admet-292	1090	6	accession	accession	NOUN
admet-292	1090	7	date	date	NOUN
admet-292	1090	8	:	:	PUNCT
admet-292	1090	9	june	june	PROPN
admet-292	1090	10	23	23	NUM
admet-292	1090	11	,	,	PUNCT
admet-292	1090	12	2016	2016	NUM
admet-292	1090	13	.	.	PUNCT
admet-292	1091	1	[	[	X
admet-292	1091	2	79	79	NUM
admet-292	1091	3	]	]	PUNCT
admet-292	1091	4	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8endeavor/overview.html	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8endeavor/overview.html	PROPN
admet-292	1091	5	.	.	PUNCT
admet-292	1091	6	accession	accession	NOUN
admet-292	1091	7	date	date	NOUN
admet-292	1091	8	:	:	PUNCT
admet-292	1091	9	june	june	PROPN
admet-292	1091	10	23	23	NUM
admet-292	1091	11	,	,	PUNCT
admet-292	1091	12	2016	2016	NUM
admet-292	1091	13	.	.	PUNCT
admet-292	1092	1	[	[	X
admet-292	1092	2	80	80	NUM
admet-292	1092	3	]	]	X
admet-292	1092	4	t.n	t.n	PROPN
admet-292	1092	5	.	.	PROPN
admet-292	1092	6	drebushchak	drebushchak	PROPN
admet-292	1092	7	,	,	PUNCT
admet-292	1092	8	yu.a	yu.a	PROPN
admet-292	1092	9	.	.	PUNCT
admet-292	1093	1	chesalov	chesalov	PROPN
admet-292	1093	2	,	,	PUNCT
admet-292	1093	3	e.v	e.v	PROPN
admet-292	1093	4	.	.	PROPN
admet-292	1093	5	boldyreva	boldyreva	PROPN
admet-292	1093	6	.	.	PUNCT
admet-292	1094	1	acta	acta	PROPN
admet-292	1094	2	crystallogr	crystallogr	PROPN
admet-292	1094	3	.	.	PUNCT
admet-292	1095	1	b	b	X
admet-292	1095	2	65	65	NUM
admet-292	1095	3	(	(	PUNCT
admet-292	1095	4	2009	2009	NUM
admet-292	1095	5	)	)	PUNCT
admet-292	1095	6	770	770	NUM
admet-292	1095	7	-	-	SYM
admet-292	1095	8	781	781	NUM
admet-292	1095	9	.	.	PUNCT
admet-292	1096	1	[	[	X
admet-292	1096	2	81	81	NUM
admet-292	1096	3	]	]	PUNCT
admet-292	1096	4	http://www.renishaw.com/en/invia-confocal-raman-microscope--6260	http://www.renishaw.com/en/invia-confocal-raman-microscope--6260	X
admet-292	1096	5	.	.	PUNCT
admet-292	1096	6	accession	accession	NOUN
admet-292	1096	7	date	date	NOUN
admet-292	1096	8	:	:	PUNCT
admet-292	1096	9	june	june	PROPN
admet-292	1096	10	23	23	NUM
admet-292	1096	11	,	,	PUNCT
admet-292	1096	12	2016	2016	NUM
admet-292	1096	13	.	.	PUNCT
admet-292	1097	1	[	[	X
admet-292	1097	2	82	82	NUM
admet-292	1097	3	]	]	X
admet-292	1097	4	s.	s.	PROPN
admet-292	1097	5	childs	childs	PROPN
admet-292	1097	6	,	,	PUNCT
admet-292	1097	7	n.	n.	PROPN
admet-292	1097	8	rodriguez	rodriguez	PROPN
admet-292	1097	9	-	-	PUNCT
admet-292	1097	10	hornedo	hornedo	PROPN
admet-292	1097	11	,	,	PUNCT
admet-292	1097	12	l.s	l.s	PROPN
admet-292	1097	13	.	.	PROPN
admet-292	1097	14	reddy	reddy	PROPN
admet-292	1097	15	,	,	PUNCT
admet-292	1097	16	a.	a.	NOUN
admet-292	1097	17	jayasankar	jayasankar	PROPN
admet-292	1097	18	,	,	PUNCT
admet-292	1097	19	c.	c.	PROPN
admet-292	1097	20	maheshwari	maheshwari	PROPN
admet-292	1097	21	,	,	PUNCT
admet-292	1097	22	l.	l.	PROPN
admet-292	1097	23	mccausland	mccausland	PROPN
admet-292	1097	24	,	,	PUNCT
admet-292	1097	25	r.	r.	PROPN
admet-292	1097	26	shipplett	shipplett	PROPN
admet-292	1097	27	,	,	PUNCT
admet-292	1097	28	b.	b.	PROPN
admet-292	1097	29	c.	c.	PROPN
admet-292	1097	30	stahly	stahly	PROPN
admet-292	1097	31	.	.	PUNCT
admet-292	1098	1	cryst	cryst	PROPN
admet-292	1098	2	.	.	PUNCT
admet-292	1099	1	eng	eng	PROPN
admet-292	1099	2	.	.	PROPN
admet-292	1099	3	comm	comm	NOUN
admet-292	1099	4	.	.	PUNCT
admet-292	1100	1	10	10	NUM
admet-292	1100	2	(	(	PUNCT
admet-292	1100	3	2008	2008	NUM
admet-292	1100	4	)	)	PUNCT
admet-292	1100	5	856	856	NUM
admet-292	1100	6	-	-	SYM
admet-292	1100	7	864	864	NUM
admet-292	1100	8	.	.	PUNCT
admet-292	1101	1	[	[	X
admet-292	1101	2	83	83	NUM
admet-292	1101	3	]	]	X
admet-292	1101	4	e.v	e.v	PROPN
admet-292	1101	5	.	.	PROPN
admet-292	1101	6	boldyreva	boldyreva	PROPN
admet-292	1101	7	,	,	PUNCT
admet-292	1101	8	s.g	s.g	PROPN
admet-292	1101	9	.	.	PROPN
admet-292	1101	10	arkhipov	arkhipov	PROPN
admet-292	1101	11	,	,	PUNCT
admet-292	1101	12	t.n	t.n	PROPN
admet-292	1101	13	.	.	PROPN
admet-292	1101	14	drebushchak	drebushchak	PROPN
admet-292	1101	15	,	,	PUNCT
admet-292	1101	16	v.a	v.a	PROPN
admet-292	1101	17	.	.	PROPN
admet-292	1101	18	drebushchak	drebushchak	PROPN
admet-292	1101	19	,	,	PUNCT
admet-292	1101	20	e.a	e.a	PROPN
admet-292	1101	21	.	.	PROPN
admet-292	1101	22	losev	losev	PROPN
admet-292	1101	23	,	,	PUNCT
admet-292	1101	24	a.a	a.a	PROPN
admet-292	1101	25	.	.	PROPN
admet-292	1101	26	matvienko	matvienko	PROPN
admet-292	1101	27	,	,	PUNCT
admet-292	1101	28	v.s.	v.s.	ADJ
admet-292	1101	29	minkov	minkov	PROPN
admet-292	1101	30	,	,	PUNCT
admet-292	1101	31	d.a	d.a	PROPN
admet-292	1101	32	.	.	PROPN
admet-292	1101	33	rychkov	rychkov	PROPN
admet-292	1101	34	,	,	PUNCT
admet-292	1101	35	yu	yu	PROPN
admet-292	1101	36	.	.	PUNCT
admet-292	1102	1	v.	v.	ADP
admet-292	1102	2	seryotkin	seryotkin	PROPN
admet-292	1102	3	,	,	PUNCT
admet-292	1102	4	j.	j.	PROPN
admet-292	1102	5	stare	stare	PROPN
admet-292	1102	6	,	,	PUNCT
admet-292	1102	7	b.a	b.a	PROPN
admet-292	1102	8	.	.	PROPN
admet-292	1102	9	zakharov	zakharov	PROPN
admet-292	1102	10	.	.	PUNCT
admet-292	1102	11	chem	chem	PROPN
admet-292	1102	12	.	.	PUNCT
admet-292	1103	1	eur	eur	PROPN
admet-292	1103	2	.	.	PUNCT
admet-292	1104	1	j.	j.	PROPN
admet-292	1104	2	21	21	NUM
admet-292	1104	3	(	(	PUNCT
admet-292	1104	4	2015	2015	NUM
admet-292	1104	5	)	)	PUNCT
admet-292	1104	6	15395	15395	NUM
admet-292	1104	7	-	-	SYM
admet-292	1104	8	15404	15404	NUM
admet-292	1104	9	.	.	PUNCT
admet-292	1105	1	[	[	X
admet-292	1105	2	84	84	NUM
admet-292	1105	3	]	]	X
admet-292	1105	4	y.	y.	PROPN
admet-292	1105	5	sakata	sakata	PROPN
admet-292	1105	6	.	.	PUNCT
admet-292	1106	1	agric	agric	PROPN
admet-292	1106	2	.	.	PUNCT
admet-292	1107	1	biol	biol	PROPN
admet-292	1107	2	.	.	PUNCT
admet-292	1108	1	chem	chem	NOUN
admet-292	1108	2	.	.	PUNCT
admet-292	1109	1	25	25	NUM
admet-292	1109	2	(	(	PUNCT
admet-292	1109	3	1964	1964	NUM
admet-292	1109	4	)	)	PUNCT
admet-292	1109	5	829	829	NUM
admet-292	1109	6	-	-	SYM
admet-292	1109	7	834	834	NUM
admet-292	1109	8	.	.	PUNCT
admet-292	1110	1	[	[	X
admet-292	1110	2	85	85	NUM
admet-292	1110	3	]	]	X
admet-292	1110	4	y.	y.	PROPN
admet-292	1110	5	sakata	sakata	PROPN
admet-292	1110	6	.	.	PUNCT
admet-292	1111	1	agric	agric	PROPN
admet-292	1111	2	.	.	PUNCT
admet-292	1112	1	biol	biol	PROPN
admet-292	1112	2	.	.	PUNCT
admet-292	1113	1	chem	chem	NOUN
admet-292	1113	2	.	.	PUNCT
admet-292	1114	1	25	25	NUM
admet-292	1114	2	(	(	PUNCT
admet-292	1114	3	1964	1964	NUM
admet-292	1114	4	)	)	PUNCT
admet-292	1114	5	835	835	NUM
admet-292	1114	6	-	-	SYM
admet-292	1114	7	837	837	NUM
admet-292	1114	8	.	.	PUNCT
admet-292	1115	1	[	[	X
admet-292	1115	2	86	86	NUM
admet-292	1115	3	]	]	PUNCT
admet-292	1115	4	c.-y	c.-y	NOUN
admet-292	1115	5	.	.	PUNCT
admet-292	1116	1	lee	lee	PROPN
admet-292	1116	2	,	,	PUNCT
admet-292	1116	3	j.-t	j.-t	PROPN
admet-292	1116	4	.	.	PUNCT
admet-292	1117	1	chen	chen	PROPN
admet-292	1117	2	,	,	PUNCT
admet-292	1117	3	w.-t	w.-t	PROPN
admet-292	1117	4	.	.	PUNCT
admet-292	1118	1	chang	chang	PROPN
admet-292	1118	2	,	,	PUNCT
admet-292	1118	3	i.-m	i.-m	PROPN
admet-292	1118	4	.	.	PUNCT
admet-292	1119	1	shiah	shiah	PROPN
admet-292	1119	2	.	.	PUNCT
admet-292	1120	1	fluid	fluid	ADJ
admet-292	1120	2	phase	phase	NOUN
admet-292	1120	3	equilib	equilib	NOUN
admet-292	1120	4	.	.	PUNCT
admet-292	1121	1	343	343	NUM
admet-292	1121	2	(	(	PUNCT
admet-292	1121	3	2013	2013	NUM
admet-292	1121	4	)	)	PUNCT
admet-292	1121	5	30	30	NUM
admet-292	1121	6	-	-	SYM
admet-292	1121	7	35	35	NUM
admet-292	1121	8	.	.	PUNCT
admet-292	1122	1	[	[	X
admet-292	1122	2	87	87	NUM
admet-292	1122	3	]	]	PUNCT
admet-292	1122	4	n.	n.	PROPN
admet-292	1122	5	schultheiss	schultheiss	PROPN
admet-292	1122	6	,	,	PUNCT
admet-292	1122	7	a.	a.	PROPN
admet-292	1122	8	newman	newman	PROPN
admet-292	1122	9	.	.	PUNCT
admet-292	1122	10	cryst	cryst	PROPN
admet-292	1122	11	.	.	PUNCT
admet-292	1123	1	growth	growth	PROPN
admet-292	1123	2	des	des	PROPN
admet-292	1123	3	.	.	PROPN
admet-292	1123	4	9	9	NUM
admet-292	1123	5	(	(	PUNCT
admet-292	1123	6	2009	2009	NUM
admet-292	1123	7	)	)	PUNCT
admet-292	1123	8	2950	2950	NUM
admet-292	1123	9	-	-	SYM
admet-292	1123	10	2967	2967	NUM
admet-292	1123	11	.	.	PUNCT
admet-292	1124	1	[	[	X
admet-292	1124	2	88	88	NUM
admet-292	1124	3	]	]	X
admet-292	1124	4	n.	n.	PROPN
admet-292	1124	5	shan	shan	PROPN
admet-292	1124	6	,	,	PUNCT
admet-292	1124	7	m.j	m.j	PROPN
admet-292	1124	8	.	.	PROPN
admet-292	1124	9	zaworotko	zaworotko	PROPN
admet-292	1124	10	.	.	PUNCT
admet-292	1125	1	drug	drug	NOUN
admet-292	1125	2	discov	discov	PROPN
admet-292	1125	3	.	.	PUNCT
admet-292	1126	1	today	today	NOUN
admet-292	1126	2	13	13	NUM
admet-292	1126	3	(	(	PUNCT
admet-292	1126	4	2008	2008	NUM
admet-292	1126	5	)	)	PUNCT
admet-292	1126	6	440	440	NUM
admet-292	1126	7	-	-	SYM
admet-292	1126	8	446	446	NUM
admet-292	1126	9	.	.	PUNCT
admet-292	1127	1	[	[	X
admet-292	1127	2	89	89	NUM
admet-292	1127	3	]	]	X
admet-292	1127	4	w.	w.	PROPN
admet-292	1127	5	jones	jones	PROPN
admet-292	1127	6	,	,	PUNCT
admet-292	1127	7	w.d.s	w.d.s	PROPN
admet-292	1127	8	.	.	PUNCT
admet-292	1128	1	motherwell	motherwell	PROPN
admet-292	1128	2	,	,	PUNCT
admet-292	1128	3	a.v	a.v	PROPN
admet-292	1128	4	.	.	PROPN
admet-292	1128	5	trask	trask	PROPN
admet-292	1128	6	.	.	PUNCT
admet-292	1129	1	mrs	mrs	PROPN
admet-292	1129	2	bull	bull	PROPN
admet-292	1129	3	.	.	PUNCT
admet-292	1130	1	31	31	NUM
admet-292	1130	2	(	(	PUNCT
admet-292	1130	3	2006	2006	NUM
admet-292	1130	4	)	)	PUNCT
admet-292	1130	5	875	875	NUM
admet-292	1130	6	-	-	SYM
admet-292	1130	7	879	879	NUM
admet-292	1130	8	.	.	PUNCT
admet-292	1131	1	[	[	X
admet-292	1131	2	90	90	NUM
admet-292	1131	3	]	]	X
admet-292	1131	4	a.v	a.v	PROPN
admet-292	1131	5	.	.	PROPN
admet-292	1131	6	trask	trask	PROPN
admet-292	1131	7	.	.	PUNCT
admet-292	1132	1	molec	molec	PROPN
admet-292	1132	2	.	.	PUNCT
admet-292	1133	1	pharmaceut	pharmaceut	PROPN
admet-292	1133	2	.	.	PUNCT
admet-292	1134	1	4	4	NUM
admet-292	1134	2	(	(	PUNCT
admet-292	1134	3	2007	2007	NUM
admet-292	1134	4	)	)	PUNCT
admet-292	1134	5	301	301	NUM
admet-292	1134	6	-	-	NUM
admet-292	1134	7	309	309	NUM
admet-292	1134	8	.	.	PUNCT
admet-292	1135	1	[	[	X
admet-292	1135	2	91	91	NUM
admet-292	1135	3	]	]	X
admet-292	1135	4	n.	n.	PROPN
admet-292	1135	5	qiao	qiao	PROPN
admet-292	1135	6	,	,	PUNCT
admet-292	1135	7	m.	m.	PROPN
admet-292	1135	8	li	li	PROPN
admet-292	1135	9	,	,	PUNCT
admet-292	1135	10	w.	w.	PROPN
admet-292	1135	11	schlindwein	schlindwein	PROPN
admet-292	1135	12	,	,	PUNCT
admet-292	1135	13	n.	n.	PROPN
admet-292	1135	14	malek	malek	PROPN
admet-292	1135	15	,	,	PUNCT
admet-292	1135	16	a.	a.	NOUN
admet-292	1135	17	davies	davy	NOUN
admet-292	1135	18	,	,	PUNCT
admet-292	1135	19	g.	g.	PROPN
admet-292	1135	20	trappitt	trappitt	PROPN
admet-292	1135	21	.	.	PUNCT
admet-292	1136	1	int	int	NOUN
admet-292	1136	2	.	.	PUNCT
admet-292	1137	1	j.	j.	PROPN
admet-292	1137	2	pharm	pharm	PROPN
admet-292	1137	3	.	.	PUNCT
admet-292	1138	1	419	419	NUM
admet-292	1138	2	(	(	PUNCT
admet-292	1138	3	2011	2011	NUM
admet-292	1138	4	)	)	PUNCT
admet-292	1138	5	1	1	NUM
admet-292	1138	6	-	-	SYM
admet-292	1138	7	11	11	NUM
admet-292	1138	8	.	.	PUNCT
admet-292	1139	1	[	[	X
admet-292	1139	2	92	92	NUM
admet-292	1139	3	]	]	PUNCT
admet-292	1139	4	r.	r.	PROPN
admet-292	1139	5	thakuria	thakuria	PROPN
admet-292	1139	6	,	,	PUNCT
admet-292	1139	7	a.	a.	PROPN
admet-292	1139	8	delori	delori	PROPN
admet-292	1139	9	,	,	PUNCT
admet-292	1139	10	w.	w.	PROPN
admet-292	1139	11	jones	jones	PROPN
admet-292	1139	12	,	,	PUNCT
admet-292	1139	13	m.p	m.p	PROPN
admet-292	1139	14	.	.	PROPN
admet-292	1139	15	lipert	lipert	PROPN
admet-292	1139	16	,	,	PUNCT
admet-292	1139	17	l.	l.	PROPN
admet-292	1139	18	roy	roy	PROPN
admet-292	1139	19	,	,	PUNCT
admet-292	1139	20	n.	n.	PROPN
admet-292	1139	21	rodríguez	rodríguez	PROPN
admet-292	1139	22	-	-	PUNCT
admet-292	1139	23	hornedo	hornedo	PROPN
admet-292	1139	24	.	.	PUNCT
admet-292	1140	1	int	int	NOUN
admet-292	1140	2	.	.	PUNCT
admet-292	1141	1	j.	j.	PROPN
admet-292	1141	2	pharm	pharm	PROPN
admet-292	1141	3	.	.	PUNCT
admet-292	1142	1	453	453	NUM
admet-292	1142	2	(	(	PUNCT
admet-292	1142	3	2013	2013	NUM
admet-292	1142	4	)	)	PUNCT
admet-292	1142	5	101125	101125	NUM
admet-292	1142	6	.	.	PUNCT
admet-292	1143	1	[	[	X
admet-292	1143	2	93	93	NUM
admet-292	1143	3	]	]	X
admet-292	1143	4	h.g	h.g	PROPN
admet-292	1143	5	.	.	PUNCT
admet-292	1143	6	brittain	brittain	PROPN
admet-292	1143	7	.	.	PUNCT
admet-292	1144	1	j.	j.	PROPN
admet-292	1144	2	pharm	pharm	PROPN
admet-292	1144	3	.	.	PUNCT
admet-292	1145	1	sci	sci	PROPN
admet-292	1145	2	.	.	PROPN
admet-292	1146	1	102	102	NUM
admet-292	1146	2	(	(	PUNCT
admet-292	1146	3	2013	2013	NUM
admet-292	1146	4	)	)	PUNCT
admet-292	1146	5	311	311	NUM
admet-292	1146	6	-	-	SYM
admet-292	1146	7	317	317	NUM
admet-292	1146	8	.	.	PUNCT
admet-292	1147	1	[	[	X
admet-292	1147	2	94	94	NUM
admet-292	1147	3	]	]	PUNCT
admet-292	1147	4	ö.	ö.	PROPN
admet-292	1147	5	almarsson	almarsson	PROPN
admet-292	1147	6	,	,	PUNCT
admet-292	1147	7	m.l	m.l	PROPN
admet-292	1147	8	.	.	PROPN
admet-292	1147	9	peterson	peterson	PROPN
admet-292	1147	10	,	,	PUNCT
admet-292	1147	11	m.	m.	NOUN
admet-292	1147	12	zaworotko	zaworotko	PROPN
admet-292	1147	13	.	.	PUNCT
admet-292	1148	1	pharm	pharm	PROPN
admet-292	1148	2	.	.	PUNCT
admet-292	1149	1	patent	patent	NOUN
admet-292	1149	2	analyst	analyst	NOUN
admet-292	1149	3	1	1	NUM
admet-292	1149	4	(	(	PUNCT
admet-292	1149	5	2012	2012	NUM
admet-292	1149	6	)	)	PUNCT
admet-292	1149	7	313	313	NUM
admet-292	1149	8	-	-	SYM
admet-292	1149	9	327	327	NUM
admet-292	1149	10	.	.	PUNCT
admet-292	1150	1	[	[	X
admet-292	1150	2	95	95	NUM
admet-292	1150	3	]	]	X
admet-292	1150	4	r.	r.	PROPN
admet-292	1150	5	chadha	chadha	PROPN
admet-292	1150	6	,	,	PUNCT
admet-292	1150	7	a.	a.	PROPN
admet-292	1150	8	saini	saini	PROPN
admet-292	1150	9	,	,	PUNCT
admet-292	1150	10	p.	p.	PROPN
admet-292	1150	11	arora	arora	PROPN
admet-292	1150	12	,	,	PUNCT
admet-292	1150	13	s.	s.	PROPN
admet-292	1150	14	bhandari	bhandari	PROPN
admet-292	1150	15	.	.	PUNCT
admet-292	1150	16	crit	crit	PROPN
admet-292	1150	17	.	.	PUNCT
admet-292	1151	1	rev	rev	PROPN
admet-292	1151	2	.	.	PROPN
admet-292	1152	1	ther	ther	PROPN
admet-292	1152	2	.	.	PUNCT
admet-292	1153	1	drug	drug	NOUN
admet-292	1153	2	carrier	carrier	NOUN
admet-292	1153	3	syst	syst	PROPN
admet-292	1153	4	.	.	PUNCT
admet-292	1154	1	29	29	NUM
admet-292	1154	2	(	(	PUNCT
admet-292	1154	3	2012	2012	NUM
admet-292	1154	4	)	)	PUNCT
admet-292	1154	5	183	183	NUM
admet-292	1154	6	-	-	SYM
admet-292	1154	7	218	218	NUM
admet-292	1154	8	.	.	PUNCT
admet-292	1155	1	[	[	X
admet-292	1155	2	96	96	NUM
admet-292	1155	3	]	]	X
admet-292	1155	4	f.	f.	PROPN
admet-292	1155	5	cao	cao	PROPN
admet-292	1155	6	,	,	PUNCT
admet-292	1155	7	g.l	g.l	PROPN
admet-292	1155	8	.	.	PROPN
admet-292	1155	9	amidon	amidon	PROPN
admet-292	1155	10	,	,	PUNCT
admet-292	1155	11	n.	n.	PROPN
admet-292	1155	12	rodriguez	rodriguez	PROPN
admet-292	1155	13	-	-	PUNCT
admet-292	1155	14	hornedo	hornedo	PROPN
admet-292	1155	15	,	,	PUNCT
admet-292	1155	16	g.	g.	PROPN
admet-292	1155	17	e.	e.	PROPN
admet-292	1155	18	amidon	amidon	PROPN
admet-292	1155	19	.	.	PUNCT
admet-292	1156	1	molec	molec	PROPN
admet-292	1156	2	.	.	PUNCT
admet-292	1157	1	pharmaceut	pharmaceut	PROPN
admet-292	1157	2	.	.	PUNCT
admet-292	1158	1	13	13	NUM
admet-292	1158	2	(	(	PUNCT
admet-292	1158	3	2016	2016	NUM
admet-292	1158	4	)	)	PUNCT
admet-292	1158	5	1030	1030	NUM
admet-292	1158	6	-	-	SYM
admet-292	1158	7	1046	1046	NUM
admet-292	1158	8	.	.	PUNCT
admet-292	1159	1	[	[	X
admet-292	1159	2	97	97	NUM
admet-292	1159	3	]	]	X
admet-292	1159	4	c.	c.	PROPN
admet-292	1159	5	maheshwari	maheshwari	PROPN
admet-292	1159	6	,	,	PUNCT
admet-292	1159	7	a.	a.	NOUN
admet-292	1159	8	jayasankar	jayasankar	PROPN
admet-292	1159	9	,	,	PUNCT
admet-292	1159	10	n.a	n.a	PROPN
admet-292	1159	11	.	.	PROPN
admet-292	1159	12	khan	khan	PROPN
admet-292	1159	13	,	,	PUNCT
admet-292	1159	14	g.e	g.e	PROPN
admet-292	1159	15	.	.	PROPN
admet-292	1159	16	amidon	amidon	PROPN
admet-292	1159	17	,	,	PUNCT
admet-292	1159	18	n.	n.	PROPN
admet-292	1159	19	rodríguez	rodríguez	PROPN
admet-292	1159	20	-	-	PUNCT
admet-292	1159	21	hornedo	hornedo	PROPN
admet-292	1159	22	.	.	PUNCT
admet-292	1160	1	cryst	cryst	PROPN
admet-292	1160	2	.	.	PUNCT
admet-292	1161	1	eng	eng	PROPN
admet-292	1161	2	.	.	PROPN
admet-292	1161	3	comm	comm	NOUN
admet-292	1161	4	.	.	PUNCT
admet-292	1161	5	 	 	SPACE
admet-292	1162	1	11	11	NUM
admet-292	1162	2	(	(	PUNCT
admet-292	1162	3	2009	2009	NUM
admet-292	1162	4	)	)	PUNCT
admet-292	1162	5	493	493	NUM
admet-292	1162	6	-	-	SYM
admet-292	1162	7	500	500	NUM
admet-292	1162	8	.	.	PUNCT
admet-292	1163	1	[	[	X
admet-292	1163	2	98	98	NUM
admet-292	1163	3	]	]	X
admet-292	1163	4	d.	d.	PROPN
admet-292	1163	5	good	good	PROPN
admet-292	1163	6	,	,	PUNCT
admet-292	1163	7	c.	c.	PROPN
admet-292	1163	8	miranda	miranda	PROPN
admet-292	1163	9	,	,	PUNCT
admet-292	1163	10	n.	n.	PROPN
admet-292	1163	11	rodríguez	rodríguez	PROPN
admet-292	1163	12	-	-	PUNCT
admet-292	1163	13	hornedo	hornedo	PROPN
admet-292	1163	14	.	.	PUNCT
admet-292	1164	1	cryst	cryst	PROPN
admet-292	1164	2	.	.	PUNCT
admet-292	1165	1	eng	eng	PROPN
admet-292	1165	2	.	.	PROPN
admet-292	1165	3	comm	comm	NOUN
admet-292	1165	4	.	.	PUNCT
admet-292	1165	5	  	  	SPACE
admet-292	1166	1	13	13	NUM
admet-292	1166	2	(	(	PUNCT
admet-292	1166	3	2011	2011	NUM
admet-292	1166	4	)	)	PUNCT
admet-292	1166	5	1181	1181	NUM
admet-292	1166	6	-	-	SYM
admet-292	1166	7	1189	1189	NUM
admet-292	1166	8	.	.	PUNCT
admet-292	1167	1	[	[	X
admet-292	1167	2	99	99	NUM
admet-292	1167	3	]	]	X
admet-292	1167	4	n.j	n.j	PROPN
admet-292	1167	5	.	.	PROPN
admet-292	1167	6	babu	babu	PROPN
admet-292	1167	7	,	,	PUNCT
admet-292	1167	8	a.	a.	PROPN
admet-292	1167	9	nangia	nangia	PROPN
admet-292	1167	10	.	.	PUNCT
admet-292	1168	1	cryst	cryst	PROPN
admet-292	1168	2	.	.	PUNCT
admet-292	1169	1	growth	growth	PROPN
admet-292	1169	2	des	des	PROPN
admet-292	1169	3	.	.	PROPN
admet-292	1169	4	11	11	NUM
admet-292	1169	5	(	(	PUNCT
admet-292	1169	6	2011	2011	NUM
admet-292	1169	7	)	)	PUNCT
admet-292	1169	8	2662	2662	NUM
admet-292	1169	9	-	-	SYM
admet-292	1169	10	2679	2679	NUM
admet-292	1169	11	.	.	PUNCT
admet-292	1170	1	[	[	X
admet-292	1170	2	100	100	NUM
admet-292	1170	3	]	]	X
admet-292	1170	4	d.r	d.r	PROPN
admet-292	1170	5	.	.	PROPN
admet-292	1170	6	weyna	weyna	PROPN
admet-292	1170	7	,	,	PUNCT
admet-292	1170	8	t.	t.	NOUN
admet-292	1170	9	shattock	shattock	NOUN
admet-292	1170	10	,	,	PUNCT
admet-292	1170	11	p.	p.	NOUN
admet-292	1170	12	vishweshwar	vishweshwar	NOUN
admet-292	1170	13	,	,	PUNCT
admet-292	1170	14	m.j	m.j	PROPN
admet-292	1170	15	.	.	PROPN
admet-292	1170	16	zaworotko	zaworotko	PROPN
admet-292	1170	17	.	.	PUNCT
admet-292	1171	1	cryst	cryst	PROPN
admet-292	1171	2	.	.	PUNCT
admet-292	1172	1	growth	growth	PROPN
admet-292	1172	2	des	des	PROPN
admet-292	1172	3	.	.	PROPN
admet-292	1172	4	9	9	NUM
admet-292	1172	5	(	(	PUNCT
admet-292	1172	6	2009	2009	NUM
admet-292	1172	7	)	)	PUNCT
admet-292	1172	8	1106	1106	NUM
admet-292	1172	9	-	-	SYM
admet-292	1172	10	1123	1123	NUM
admet-292	1172	11	.	.	PUNCT
admet-292	1173	1	[	[	X
admet-292	1173	2	101	101	NUM
admet-292	1173	3	]	]	PUNCT
admet-292	1173	4	i.	i.	PROPN
admet-292	1173	5	halasz	halasz	PROPN
admet-292	1173	6	,	,	PUNCT
admet-292	1173	7	a.	a.	NOUN
admet-292	1173	8	puškarić	puškarić	NOUN
admet-292	1173	9	,	,	PUNCT
admet-292	1173	10	s.a.j	s.a.j	PROPN
admet-292	1173	11	.	.	PUNCT
admet-292	1174	1	kimber	kimber	PROPN
admet-292	1174	2	,	,	PUNCT
admet-292	1174	3	p.j	p.j	PROPN
admet-292	1174	4	.	.	PROPN
admet-292	1174	5	beldon	beldon	PROPN
admet-292	1174	6	,	,	PUNCT
admet-292	1174	7	a.m.	a.m.	PROPN
admet-292	1174	8	belenguer	belenguer	PROPN
admet-292	1174	9	,	,	PUNCT
admet-292	1174	10	f.	f.	PROPN
admet-292	1174	11	adams	adams	PROPN
admet-292	1174	12	,	,	PUNCT
admet-292	1174	13	v.	v.	PROPN
admet-292	1174	14	honkimäki	honkimäki	PROPN
admet-292	1174	15	,	,	PUNCT
admet-292	1174	16	r.e	r.e	PROPN
admet-292	1174	17	.	.	PROPN
admet-292	1174	18	dinnebier	dinnebier	PROPN
admet-292	1174	19	,	,	PUNCT
admet-292	1174	20	b.	b.	PROPN
admet-292	1174	21	patel	patel	PROPN
admet-292	1174	22	,	,	PUNCT
admet-292	1174	23	w.	w.	PROPN
admet-292	1174	24	jones	jones	PROPN
admet-292	1174	25	,	,	PUNCT
admet-292	1174	26	v.	v.	ADP
admet-292	1174	27	štrukil	štrukil	NOUN
admet-292	1174	28	,	,	PUNCT
admet-292	1174	29	t.	t.	PROPN
admet-292	1174	30	friščić	friščić	PROPN
admet-292	1174	31	.	.	PUNCT
admet-292	1175	1	angew	angew	PROPN
admet-292	1175	2	.	.	PUNCT
admet-292	1176	1	chemie	chemie	PROPN
admet-292	1176	2	int	int	PROPN
admet-292	1176	3	.	.	PUNCT
admet-292	1177	1	ed	ed	NOUN
admet-292	1177	2	.	.	PROPN
admet-292	1178	1	52	52	NUM
admet-292	1178	2	(	(	PUNCT
admet-292	1178	3	2013	2013	NUM
admet-292	1178	4	)	)	PUNCT
admet-292	1178	5	11538–11541	11538–11541	NUM
admet-292	1178	6	.	.	PUNCT
admet-292	1179	1	[	[	X
admet-292	1179	2	102	102	NUM
admet-292	1179	3	]	]	X
admet-292	1179	4	s.a	s.a	PROPN
admet-292	1179	5	.	.	PROPN
admet-292	1179	6	myz	myz	PROPN
admet-292	1179	7	,	,	PUNCT
admet-292	1179	8	t.p	t.p	PROPN
admet-292	1179	9	.	.	PROPN
admet-292	1179	10	shakhtshneider	shakhtshneider	PROPN
admet-292	1179	11	,	,	PUNCT
admet-292	1179	12	k.	k.	PROPN
admet-292	1179	13	fucke	fucke	PROPN
admet-292	1179	14	,	,	PUNCT
admet-292	1179	15	a.p	a.p	PROPN
admet-292	1179	16	.	.	PROPN
admet-292	1179	17	fedotov	fedotov	PROPN
admet-292	1179	18	,	,	PUNCT
admet-292	1179	19	e.v	e.v	PROPN
admet-292	1179	20	.	.	PROPN
admet-292	1179	21	boldyreva	boldyreva	PROPN
admet-292	1179	22	,	,	PUNCT
admet-292	1179	23	v.v	v.v	PROPN
admet-292	1179	24	.	.	PROPN
admet-292	1179	25	boldyrev	boldyrev	PROPN
admet-292	1179	26	,	,	PUNCT
admet-292	1179	27	n.i	n.i	PROPN
admet-292	1179	28	.	.	PROPN
admet-292	1179	29	kuleshova	kuleshova	PROPN
admet-292	1179	30	.	.	PUNCT
admet-292	1180	1	mendeleev	mendeleev	PROPN
admet-292	1180	2	comm	comm	NOUN
admet-292	1180	3	.	.	PUNCT
admet-292	1181	1	19	19	NUM
admet-292	1181	2	(	(	PUNCT
admet-292	1181	3	2009	2009	NUM
admet-292	1181	4	)	)	PUNCT
admet-292	1181	5	272	272	NUM
admet-292	1181	6	-	-	SYM
admet-292	1181	7	274	274	NUM
admet-292	1181	8	.	.	PUNCT
admet-292	1182	1	http://www.panalytical.com/xpert3-powder.htm	http://www.panalytical.com/xpert3-powder.htm	PROPN
admet-292	1182	2	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8-endeavor/overview.html	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8-endeavor/overview.html	PROPN
admet-292	1182	3	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8-endeavor/overview.html	https://www.bruker.com/products/x-ray-diffraction-and-elemental-analysis/x-ray-diffraction/d8-endeavor/overview.html	PROPN
admet-292	1182	4	http://www.renishaw.com/en/invia-confocal-raman-microscope--6260	http://www.renishaw.com/en/invia-confocal-raman-microscope--6260	PROPN
admet-292	1182	5	alex	alex	PROPN
admet-292	1182	6	avdeef	avdeef	PROPN
admet-292	1182	7	et	et	PROPN
admet-292	1182	8	al	al	PROPN
admet-292	1182	9	.	.	PROPN
admet-292	1182	10	admet	admet	PROPN
admet-292	1182	11	&	&	CCONJ
admet-292	1182	12	dmpk	dmpk	PROPN
admet-292	1182	13	4(2	4(2	NUM
admet-292	1182	14	)	)	PUNCT
admet-292	1182	15	(	(	PUNCT
admet-292	1182	16	2016	2016	NUM
admet-292	1182	17	)	)	PUNCT
admet-292	1182	18	117	117	NUM
admet-292	1182	19	-	-	SYM
admet-292	1182	20	178	178	NUM
admet-292	1182	21	160	160	NUM
admet-292	1182	22	[	[	X
admet-292	1182	23	103	103	NUM
admet-292	1182	24	]	]	PUNCT
admet-292	1182	25	t.	t.	NOUN
admet-292	1182	26	friščić	friščić	NOUN
admet-292	1182	27	,	,	PUNCT
admet-292	1182	28	w.	w.	PROPN
admet-292	1182	29	jones	jones	PROPN
admet-292	1182	30	.	.	PUNCT
admet-292	1183	1	cryst	cryst	PROPN
admet-292	1183	2	.	.	PUNCT
admet-292	1184	1	growth	growth	PROPN
admet-292	1184	2	des	des	PROPN
admet-292	1184	3	.	.	PROPN
admet-292	1184	4	9	9	NUM
admet-292	1184	5	(	(	PUNCT
admet-292	1184	6	2009	2009	NUM
admet-292	1184	7	)	)	PUNCT
admet-292	1184	8	1621	1621	NUM
admet-292	1184	9	-	-	SYM
admet-292	1184	10	1637	1637	NUM
admet-292	1184	11	.	.	PUNCT
admet-292	1185	1	[	[	X
admet-292	1185	2	104	104	X
admet-292	1185	3	]	]	X
admet-292	1185	4	d.	d.	PROPN
admet-292	1185	5	braga	braga	PROPN
admet-292	1185	6	,	,	PUNCT
admet-292	1185	7	l.	l.	PROPN
admet-292	1185	8	maini	maini	PROPN
admet-292	1185	9	,	,	PUNCT
admet-292	1185	10	f.	f.	PROPN
admet-292	1185	11	grepioni	grepioni	PROPN
admet-292	1185	12	.	.	PUNCT
admet-292	1186	1	chem	chem	NOUN
admet-292	1186	2	.	.	PUNCT
admet-292	1187	1	soc	soc	PROPN
admet-292	1187	2	.	.	PUNCT
admet-292	1188	1	rev	rev	PROPN
admet-292	1188	2	.	.	PROPN
admet-292	1189	1	42	42	NUM
admet-292	1189	2	(	(	PUNCT
admet-292	1189	3	2013	2013	NUM
admet-292	1189	4	)	)	PUNCT
admet-292	1189	5	7638	7638	NUM
admet-292	1189	6	-	-	SYM
admet-292	1189	7	7648	7648	NUM
admet-292	1189	8	.	.	PUNCT
admet-292	1190	1	[	[	X
admet-292	1190	2	105	105	NUM
admet-292	1190	3	]	]	X
admet-292	1190	4	c.w	c.w	PROPN
admet-292	1190	5	.	.	PROPN
admet-292	1190	6	pouton	pouton	PROPN
admet-292	1190	7	.	.	PUNCT
admet-292	1191	1	adv	adv	PROPN
admet-292	1191	2	.	.	PUNCT
admet-292	1191	3	drug	drug	PROPN
admet-292	1191	4	deliv	deliv	PROPN
admet-292	1191	5	.	.	PUNCT
admet-292	1192	1	rev	rev	PROPN
admet-292	1192	2	.	.	PROPN
admet-292	1192	3	25	25	NUM
admet-292	1192	4	(	(	PUNCT
admet-292	1192	5	1997	1997	NUM
admet-292	1192	6	)	)	PUNCT
admet-292	1192	7	47	47	NUM
admet-292	1192	8	-	-	SYM
admet-292	1192	9	58	58	NUM
admet-292	1192	10	.	.	PUNCT
admet-292	1193	1	[	[	X
admet-292	1193	2	106	106	X
admet-292	1193	3	]	]	X
admet-292	1193	4	v.p	v.p	PROPN
admet-292	1193	5	.	.	PROPN
admet-292	1193	6	torchilin	torchilin	PROPN
admet-292	1193	7	.	.	PUNCT
admet-292	1194	1	j.	j.	PROPN
admet-292	1194	2	control	control	PROPN
admet-292	1194	3	.	.	PUNCT
admet-292	1195	1	rel	rel	PROPN
admet-292	1195	2	.	.	PUNCT
admet-292	1196	1	73	73	NUM
admet-292	1196	2	(	(	PUNCT
admet-292	1196	3	2001	2001	NUM
admet-292	1196	4	)	)	PUNCT
admet-292	1196	5	137	137	NUM
admet-292	1196	6	-	-	SYM
admet-292	1196	7	172	172	NUM
admet-292	1196	8	.	.	PUNCT
admet-292	1197	1	[	[	X
admet-292	1197	2	107	107	NUM
admet-292	1197	3	]	]	X
admet-292	1197	4	n.	n.	PROPN
admet-292	1197	5	huang	huang	PROPN
admet-292	1197	6	,	,	PUNCT
admet-292	1197	7	n.	n.	PROPN
admet-292	1197	8	rodríguez	rodríguez	PROPN
admet-292	1197	9	-	-	PUNCT
admet-292	1197	10	hornedo	hornedo	PROPN
admet-292	1197	11	.	.	PUNCT
admet-292	1198	1	j.	j.	PROPN
admet-292	1198	2	pharm	pharm	PROPN
admet-292	1198	3	.	.	PUNCT
admet-292	1199	1	sci	sci	PROPN
admet-292	1199	2	.	.	PROPN
admet-292	1199	3	100	100	NUM
admet-292	1199	4	(	(	PUNCT
admet-292	1199	5	2011	2011	NUM
admet-292	1199	6	)	)	PUNCT
admet-292	1199	7	5219	5219	NUM
admet-292	1199	8	-	-	SYM
admet-292	1199	9	5234	5234	NUM
admet-292	1199	10	.	.	PUNCT
admet-292	1200	1	[	[	X
admet-292	1200	2	108	108	NUM
admet-292	1200	3	]	]	X
admet-292	1200	4	n.	n.	PROPN
admet-292	1200	5	rodriguez	rodriguez	PROPN
admet-292	1200	6	-	-	PUNCT
admet-292	1200	7	hornedo	hornedo	PROPN
admet-292	1200	8	.	.	PUNCT
admet-292	1200	9	s.j	s.j	PROPN
admet-292	1200	10	.	.	PROPN
admet-292	1200	11	nehm	nehm	PROPN
admet-292	1200	12	,	,	PUNCT
admet-292	1200	13	k.f	k.f	PROPN
admet-292	1200	14	.	.	PROPN
admet-292	1200	15	seefeldt	seefeldt	PROPN
admet-292	1200	16	,	,	PUNCT
admet-292	1200	17	y.	y.	PROPN
admet-292	1200	18	pagan	pagan	PROPN
admet-292	1200	19	-	-	PUNCT
admet-292	1200	20	torres	torre	NOUN
admet-292	1200	21	,	,	PUNCT
admet-292	1200	22	c.j	c.j	PROPN
admet-292	1200	23	.	.	PROPN
admet-292	1200	24	falkiewicz	falkiewicz	PROPN
admet-292	1200	25	.	.	PUNCT
admet-292	1201	1	molec	molec	PROPN
admet-292	1201	2	.	.	PUNCT
admet-292	1202	1	pharmaceut	pharmaceut	PROPN
admet-292	1202	2	.	.	PUNCT
admet-292	1203	1	3	3	NUM
admet-292	1203	2	(	(	PUNCT
admet-292	1203	3	2006	2006	NUM
admet-292	1203	4	)	)	PUNCT
admet-292	1203	5	362	362	NUM
admet-292	1203	6	-	-	SYM
admet-292	1203	7	367	367	NUM
admet-292	1203	8	.	.	PUNCT
admet-292	1204	1	[	[	X
admet-292	1204	2	109	109	NUM
admet-292	1204	3	]	]	X
admet-292	1204	4	m.h	m.h	PROPN
admet-292	1204	5	.	.	PROPN
admet-292	1204	6	abraham	abraham	PROPN
admet-292	1204	7	,	,	PUNCT
admet-292	1204	8	j.	j.	PROPN
admet-292	1204	9	le	le	PROPN
admet-292	1204	10	.	.	PUNCT
admet-292	1204	11	j.	j.	PROPN
admet-292	1204	12	pharm	pharm	PROPN
admet-292	1204	13	.	.	PUNCT
admet-292	1205	1	sci	sci	PROPN
admet-292	1205	2	.	.	PROPN
admet-292	1205	3	88	88	NUM
admet-292	1205	4	(	(	PUNCT
admet-292	1205	5	1999	1999	NUM
admet-292	1205	6	)	)	PUNCT
admet-292	1205	7	868	868	NUM
admet-292	1205	8	-	-	SYM
admet-292	1205	9	880	880	NUM
admet-292	1205	10	.	.	PUNCT
admet-292	1206	1	[	[	X
admet-292	1206	2	110	110	NUM
admet-292	1206	3	]	]	X
admet-292	1206	4	e.	e.	PROPN
admet-292	1206	5	rytting	rytting	PROPN
admet-292	1206	6	,	,	PUNCT
admet-292	1206	7	k.a	k.a	PROPN
admet-292	1206	8	.	.	PROPN
admet-292	1206	9	lentz	lentz	PROPN
admet-292	1206	10	,	,	PUNCT
admet-292	1206	11	x.q	x.q	PROPN
admet-292	1206	12	.	.	PROPN
admet-292	1206	13	chen	chen	PROPN
admet-292	1206	14	,	,	PUNCT
admet-292	1206	15	f.	f.	PROPN
admet-292	1206	16	qian	qian	PROPN
admet-292	1206	17	,	,	PUNCT
admet-292	1206	18	s.	s.	PROPN
admet-292	1206	19	venkatesh	venkatesh	PROPN
admet-292	1206	20	.	.	PUNCT
admet-292	1207	1	pharm	pharm	NOUN
admet-292	1207	2	res	re	NOUN
admet-292	1207	3	.	.	PUNCT
admet-292	1208	1	21	21	NUM
admet-292	1208	2	(	(	PUNCT
admet-292	1208	3	2004	2004	NUM
admet-292	1208	4	)	)	PUNCT
admet-292	1208	5	237	237	NUM
admet-292	1208	6	-	-	SYM
admet-292	1208	7	244	244	NUM
admet-292	1208	8	.	.	PUNCT
admet-292	1209	1	[	[	X
admet-292	1209	2	111	111	NUM
admet-292	1209	3	]	]	PUNCT
admet-292	1209	4	g.	g.	PROPN
admet-292	1209	5	biedermann	biedermann	PROPN
admet-292	1209	6	,	,	PUNCT
admet-292	1209	7	l.g	l.g	PROPN
admet-292	1209	8	.	.	PROPN
admet-292	1209	9	sillén	sillén	PROPN
admet-292	1209	10	.	.	PUNCT
admet-292	1210	1	arkiv	arkiv	NOUN
admet-292	1210	2	.	.	PUNCT
admet-292	1211	1	kemi	kemi	PROPN
admet-292	1211	2	.	.	PROPN
admet-292	1212	1	5	5	NUM
admet-292	1212	2	(	(	PUNCT
admet-292	1212	3	1952	1952	NUM
admet-292	1212	4	)	)	PUNCT
admet-292	1212	5	425	425	NUM
admet-292	1212	6	-	-	NUM
admet-292	1212	7	440	440	NUM
admet-292	1212	8	.	.	PUNCT
admet-292	1213	1	[	[	X
admet-292	1213	2	112	112	NUM
admet-292	1213	3	]	]	PUNCT
admet-292	1213	4	a.	a.	NOUN
admet-292	1213	5	avdeef	avdeef	PROPN
admet-292	1213	6	,	,	PUNCT
admet-292	1213	7	j.e.a	j.e.a	PROPN
admet-292	1213	8	.	.	PUNCT
admet-292	1213	9	comer	comer	PROPN
admet-292	1213	10	,	,	PUNCT
admet-292	1213	11	s.j	s.j	PROPN
admet-292	1213	12	.	.	PROPN
admet-292	1213	13	thomson	thomson	PROPN
admet-292	1213	14	.	.	PUNCT
admet-292	1214	1	anal	anal	PROPN
admet-292	1214	2	.	.	PUNCT
admet-292	1215	1	chem	chem	PROPN
admet-292	1215	2	.	.	PUNCT
admet-292	1216	1	65	65	NUM
admet-292	1216	2	(	(	PUNCT
admet-292	1216	3	1993	1993	NUM
admet-292	1216	4	)	)	PUNCT
admet-292	1216	5	42	42	NUM
admet-292	1216	6	-	-	SYM
admet-292	1216	7	49	49	NUM
admet-292	1216	8	.	.	PUNCT
admet-292	1217	1	[	[	X
admet-292	1217	2	113	113	NUM
admet-292	1217	3	]	]	PUNCT
admet-292	1217	4	a.	a.	NOUN
admet-292	1217	5	avdeef	avdeef	PROPN
admet-292	1217	6	,	,	PUNCT
admet-292	1217	7	k.j	k.j	PROPN
admet-292	1217	8	.	.	PROPN
admet-292	1217	9	box	box	PROPN
admet-292	1217	10	,	,	PUNCT
admet-292	1217	11	j.e.a	j.e.a	PROPN
admet-292	1217	12	.	.	PUNCT
admet-292	1217	13	comer	comer	PROPN
admet-292	1217	14	,	,	PUNCT
admet-292	1217	15	m.	m.	NOUN
admet-292	1217	16	gilges	gilge	NOUN
admet-292	1217	17	,	,	PUNCT
admet-292	1217	18	m.	m.	NOUN
admet-292	1217	19	hadley	hadley	PROPN
admet-292	1217	20	,	,	PUNCT
admet-292	1217	21	c.	c.	PROPN
admet-292	1217	22	hibbert	hibbert	PROPN
admet-292	1217	23	,	,	PUNCT
admet-292	1217	24	w.	w.	PROPN
admet-292	1217	25	patterson	patterson	PROPN
admet-292	1217	26	,	,	PUNCT
admet-292	1217	27	k.y	k.y	PROPN
admet-292	1217	28	.	.	PROPN
admet-292	1217	29	tam	tam	PROPN
admet-292	1217	30	.	.	PUNCT
admet-292	1217	31	j.	j.	PROPN
admet-292	1217	32	pharm	pharm	PROPN
admet-292	1217	33	.	.	PUNCT
admet-292	1217	34	biomed	biome	VERB
admet-292	1217	35	.	.	PUNCT
admet-292	1218	1	anal	anal	ADJ
admet-292	1218	2	.	.	PUNCT
admet-292	1219	1	20	20	NUM
admet-292	1219	2	(	(	PUNCT
admet-292	1219	3	1999	1999	NUM
admet-292	1219	4	)	)	PUNCT
admet-292	1219	5	631	631	NUM
admet-292	1219	6	-	-	SYM
admet-292	1219	7	641	641	NUM
admet-292	1219	8	.	.	PUNCT
admet-292	1220	1	[	[	X
admet-292	1220	2	114	114	NUM
admet-292	1220	3	]	]	PUNCT
admet-292	1220	4	v.s.	v.s.	ADJ
admet-292	1220	5	živanović	živanović	NOUN
admet-292	1220	6	,	,	PUNCT
admet-292	1220	7	m.p	m.p	PROPN
admet-292	1220	8	.	.	PROPN
admet-292	1220	9	pešić	pešić	PROPN
admet-292	1220	10	,	,	PUNCT
admet-292	1220	11	v.	v.	ADP
admet-292	1220	12	horváth	horváth	PROPN
admet-292	1220	13	,	,	PUNCT
admet-292	1220	14	j.	j.	PROPN
admet-292	1220	15	madarász	madarász	PROPN
admet-292	1220	16	,	,	PUNCT
admet-292	1220	17	i.n	i.n	PROPN
admet-292	1220	18	.	.	PROPN
admet-292	1220	19	cvijetić	cvijetić	PROPN
admet-292	1220	20	,	,	PUNCT
admet-292	1220	21	g.v	g.v	PROPN
admet-292	1220	22	.	.	PROPN
admet-292	1220	23	popović	popović	PROPN
admet-292	1220	24	,	,	PUNCT
admet-292	1220	25	t.ž	t.ž	PROPN
admet-292	1220	26	.	.	PROPN
admet-292	1220	27	verbić	verbić	PROPN
admet-292	1220	28	,	,	PUNCT
admet-292	1220	29	a.	a.	NOUN
admet-292	1220	30	avdeef	avdeef	PROPN
admet-292	1220	31	.	.	PUNCT
admet-292	1221	1	terfenadine	terfenadine	PROPN
admet-292	1221	2	solubility	solubility	NOUN
admet-292	1221	3	studies	study	NOUN
admet-292	1221	4	.	.	PUNCT
admet-292	1222	1	4th	4th	ADJ
admet-292	1222	2	world	world	NOUN
admet-292	1222	3	conference	conference	NOUN
admet-292	1222	4	on	on	ADP
admet-292	1222	5	physico	physico	NOUN
admet-292	1222	6	-	-	PUNCT
admet-292	1222	7	chemical	chemical	NOUN
admet-292	1222	8	methods	method	NOUN
admet-292	1222	9	in	in	ADP
admet-292	1222	10	drug	drug	NOUN
admet-292	1222	11	discovery	discovery	NOUN
admet-292	1222	12	and	and	CCONJ
admet-292	1222	13	development	development	NOUN
admet-292	1222	14	,	,	PUNCT
admet-292	1222	15	september	september	PROPN
admet-292	1222	16	21	21	NUM
admet-292	1222	17	-	-	SYM
admet-292	1222	18	24	24	NUM
admet-292	1222	19	,	,	PUNCT
admet-292	1222	20	2015	2015	NUM
admet-292	1222	21	,	,	PUNCT
admet-292	1222	22	red	red	ADJ
admet-292	1222	23	island	island	NOUN
admet-292	1222	24	,	,	PUNCT
admet-292	1222	25	croatia	croatia	PROPN
admet-292	1222	26	,	,	PUNCT
admet-292	1222	27	abstracts	abstract	NOUN
admet-292	1222	28	p12	p12	VERB
admet-292	1222	29	.	.	PUNCT
admet-292	1223	1	[	[	X
admet-292	1223	2	115	115	NUM
admet-292	1223	3	]	]	PUNCT
admet-292	1223	4	t.	t.	PROPN
admet-292	1223	5	higuchi	higuchi	PROPN
admet-292	1223	6	,	,	PUNCT
admet-292	1223	7	f.-m	f.-m	PROPN
admet-292	1223	8	.	.	PUNCT
admet-292	1224	1	shih	shih	NOUN
admet-292	1224	2	,	,	PUNCT
admet-292	1224	3	t.	t.	PROPN
admet-292	1224	4	kimura	kimura	PROPN
admet-292	1224	5	,	,	PUNCT
admet-292	1224	6	j.h	j.h	PROPN
admet-292	1224	7	.	.	PROPN
admet-292	1224	8	rytting	rytting	NOUN
admet-292	1224	9	.	.	PUNCT
admet-292	1225	1	j.	j.	PROPN
admet-292	1225	2	pharm	pharm	PROPN
admet-292	1225	3	.	.	PUNCT
admet-292	1226	1	sci	sci	PROPN
admet-292	1226	2	.	.	PROPN
admet-292	1227	1	68	68	NUM
admet-292	1227	2	(	(	PUNCT
admet-292	1227	3	1979	1979	NUM
admet-292	1227	4	)	)	PUNCT
admet-292	1227	5	1267	1267	NUM
admet-292	1227	6	-	-	SYM
admet-292	1227	7	1272	1272	NUM
admet-292	1227	8	.	.	PUNCT
admet-292	1228	1	[	[	X
admet-292	1228	2	116	116	X
admet-292	1228	3	]	]	X
admet-292	1228	4	j.j	j.j	PROPN
admet-292	1228	5	.	.	PROPN
admet-292	1228	6	palmgrén	palmgrén	PROPN
admet-292	1228	7	,	,	PUNCT
admet-292	1228	8	j.	j.	PROPN
admet-292	1228	9	mönkkönen	mönkkönen	PROPN
admet-292	1228	10	,	,	PUNCT
admet-292	1228	11	t.	t.	PROPN
admet-292	1228	12	korjamo	korjamo	PROPN
admet-292	1228	13	,	,	PUNCT
admet-292	1228	14	a.	a.	PROPN
admet-292	1228	15	hassinen	hassinen	PROPN
admet-292	1228	16	,	,	PUNCT
admet-292	1228	17	s.	s.	PROPN
admet-292	1228	18	auriola	auriola	PROPN
admet-292	1228	19	.	.	PUNCT
admet-292	1229	1	eur	eur	PROPN
admet-292	1229	2	.	.	PUNCT
admet-292	1230	1	j.	j.	PROPN
admet-292	1230	2	pharm	pharm	PROPN
admet-292	1230	3	.	.	PUNCT
admet-292	1231	1	biopharm	biopharm	PROPN
admet-292	1231	2	.	.	PUNCT
admet-292	1232	1	64	64	NUM
admet-292	1232	2	(	(	PUNCT
admet-292	1232	3	2006	2006	NUM
admet-292	1232	4	)	)	PUNCT
admet-292	1232	5	369	369	NUM
admet-292	1232	6	-	-	SYM
admet-292	1232	7	378	378	NUM
admet-292	1232	8	.	.	PUNCT
admet-292	1233	1	[	[	X
admet-292	1233	2	117	117	NUM
admet-292	1233	3	]	]	PUNCT
admet-292	1233	4	a.	a.	NOUN
admet-292	1233	5	glomme	glomme	PROPN
admet-292	1233	6	,	,	PUNCT
admet-292	1233	7	j.	j.	PROPN
admet-292	1233	8	märz	märz	PROPN
admet-292	1233	9	,	,	PUNCT
admet-292	1233	10	j.b	j.b	PROPN
admet-292	1233	11	.	.	PROPN
admet-292	1233	12	dressman	dressman	PROPN
admet-292	1233	13	.	.	PUNCT
admet-292	1234	1	j.	j.	PROPN
admet-292	1234	2	pharm	pharm	PROPN
admet-292	1234	3	.	.	PUNCT
admet-292	1235	1	sci	sci	PROPN
admet-292	1235	2	.	.	PROPN
admet-292	1236	1	94	94	NUM
admet-292	1236	2	(	(	PUNCT
admet-292	1236	3	2005	2005	NUM
admet-292	1236	4	)	)	PUNCT
admet-292	1236	5	1	1	NUM
admet-292	1236	6	-	-	SYM
admet-292	1236	7	16	16	NUM
admet-292	1236	8	.	.	PUNCT
admet-292	1237	1	[	[	X
admet-292	1237	2	118	118	NUM
admet-292	1237	3	]	]	PUNCT
admet-292	1237	4	c.a.s	c.a.s	PROPN
admet-292	1237	5	.	.	PROPN
admet-292	1237	6	bergström	bergström	PROPN
admet-292	1237	7	,	,	PUNCT
admet-292	1237	8	c.m	c.m	PROPN
admet-292	1237	9	.	.	PROPN
admet-292	1237	10	wassvik	wassvik	PROPN
admet-292	1237	11	,	,	PUNCT
admet-292	1237	12	k.	k.	PROPN
admet-292	1237	13	johansson	johansson	PROPN
admet-292	1237	14	,	,	PUNCT
admet-292	1237	15	i.	i.	PROPN
admet-292	1237	16	hubatsch	hubatsch	PROPN
admet-292	1237	17	.	.	PUNCT
admet-292	1238	1	j.	j.	PROPN
admet-292	1238	2	med	med	PROPN
admet-292	1238	3	.	.	PROPN
admet-292	1238	4	chem	chem	PROPN
admet-292	1238	5	.	.	PUNCT
admet-292	1239	1	50	50	NUM
admet-292	1239	2	(	(	PUNCT
admet-292	1239	3	2007	2007	NUM
admet-292	1239	4	)	)	PUNCT
admet-292	1239	5	5858	5858	NUM
admet-292	1239	6	-	-	SYM
admet-292	1239	7	5862	5862	NUM
admet-292	1239	8	.	.	PUNCT
admet-292	1240	1	[	[	X
admet-292	1240	2	119	119	NUM
admet-292	1240	3	]	]	PUNCT
admet-292	1240	4	a.	a.	NOUN
admet-292	1240	5	avdeef	avdeef	PROPN
admet-292	1240	6	,	,	PUNCT
admet-292	1240	7	m.	m.	PROPN
admet-292	1240	8	kansy	kansy	PROPN
admet-292	1240	9	,	,	PUNCT
admet-292	1240	10	s.	s.	PROPN
admet-292	1240	11	bendels	bendels	PROPN
admet-292	1240	12	,	,	PUNCT
admet-292	1240	13	k.	k.	PROPN
admet-292	1240	14	tsinman	tsinman	PROPN
admet-292	1240	15	.	.	PUNCT
admet-292	1241	1	eur	eur	PROPN
admet-292	1241	2	.	.	PUNCT
admet-292	1242	1	j.	j.	PROPN
admet-292	1242	2	pharm	pharm	PROPN
admet-292	1242	3	.	.	PUNCT
admet-292	1243	1	sci	sci	PROPN
admet-292	1243	2	.	.	PROPN
admet-292	1244	1	33	33	NUM
admet-292	1244	2	(	(	PUNCT
admet-292	1244	3	2008	2008	NUM
admet-292	1244	4	)	)	PUNCT
admet-292	1244	5	29	29	NUM
admet-292	1244	6	-	-	SYM
admet-292	1244	7	41	41	NUM
admet-292	1244	8	.	.	PUNCT
admet-292	1245	1	[	[	X
admet-292	1245	2	120	120	NUM
admet-292	1245	3	]	]	X
admet-292	1245	4	b.i	b.i	PROPN
admet-292	1245	5	.	.	PROPN
admet-292	1245	6	escher	escher	PROPN
admet-292	1245	7	,	,	PUNCT
admet-292	1245	8	c.	c.	PROPN
admet-292	1245	9	berger	berger	PROPN
admet-292	1245	10	,	,	PUNCT
admet-292	1245	11	n.	n.	PROPN
admet-292	1245	12	bramaz	bramaz	PROPN
admet-292	1245	13	,	,	PUNCT
admet-292	1245	14	j.h	j.h	PROPN
admet-292	1245	15	.	.	PROPN
admet-292	1245	16	kwon	kwon	PROPN
admet-292	1245	17	,	,	PUNCT
admet-292	1245	18	m.	m.	NOUN
admet-292	1245	19	richter	richter	PROPN
admet-292	1245	20	,	,	PUNCT
admet-292	1245	21	o.	o.	PROPN
admet-292	1245	22	tsinman	tsinman	NOUN
admet-292	1245	23	,	,	PUNCT
admet-292	1245	24	a.	a.	PROPN
admet-292	1245	25	avdeef	avdeef	PROPN
admet-292	1245	26	.	.	PUNCT
admet-292	1246	1	environ	environ	PROPN
admet-292	1246	2	.	.	PUNCT
admet-292	1247	1	tox	tox	PROPN
admet-292	1247	2	.	.	PUNCT
admet-292	1247	3	chem	chem	PROPN
admet-292	1247	4	.	.	PUNCT
admet-292	1248	1	27	27	NUM
admet-292	1248	2	(	(	PUNCT
admet-292	1248	3	2008	2008	NUM
admet-292	1248	4	)	)	PUNCT
admet-292	1248	5	909	909	NUM
admet-292	1248	6	-	-	SYM
admet-292	1248	7	918	918	NUM
admet-292	1248	8	.	.	PUNCT
admet-292	1249	1	[	[	X
admet-292	1249	2	121	121	NUM
admet-292	1249	3	]	]	PUNCT
admet-292	1249	4	c.a.s	c.a.s	PROPN
admet-292	1249	5	.	.	PROPN
admet-292	1249	6	bergström	bergström	PROPN
admet-292	1249	7	,	,	PUNCT
admet-292	1249	8	k.	k.	PROPN
admet-292	1249	9	luthman	luthman	PROPN
admet-292	1249	10	,	,	PUNCT
admet-292	1249	11	p.	p.	PROPN
admet-292	1249	12	artursson	artursson	PROPN
admet-292	1249	13	.	.	PUNCT
admet-292	1250	1	eur	eur	PROPN
admet-292	1250	2	.	.	PUNCT
admet-292	1251	1	j.	j.	PROPN
admet-292	1251	2	pharm	pharm	PROPN
admet-292	1251	3	.	.	PUNCT
admet-292	1252	1	sci	sci	PROPN
admet-292	1252	2	.	.	PROPN
admet-292	1253	1	22	22	NUM
admet-292	1253	2	(	(	PUNCT
admet-292	1253	3	2004	2004	NUM
admet-292	1253	4	)	)	PUNCT
admet-292	1253	5	387	387	NUM
admet-292	1253	6	-	-	SYM
admet-292	1253	7	398	398	NUM
admet-292	1253	8	.	.	PUNCT
admet-292	1254	1	[	[	X
admet-292	1254	2	122	122	NUM
admet-292	1254	3	]	]	PUNCT
admet-292	1254	4	t.	t.	PROPN
admet-292	1254	5	loftsson	loftsson	PROPN
admet-292	1254	6	,	,	PUNCT
admet-292	1254	7	s.b	s.b	PROPN
admet-292	1254	8	.	.	PROPN
admet-292	1254	9	vogensen	vogensen	PROPN
admet-292	1254	10	,	,	PUNCT
admet-292	1254	11	c.	c.	PROPN
admet-292	1254	12	desbos	desbos	PROPN
admet-292	1254	13	,	,	PUNCT
admet-292	1254	14	p.	p.	PROPN
admet-292	1254	15	jansook	jansook	PROPN
admet-292	1254	16	.	.	PUNCT
admet-292	1255	1	aaps	aap	NOUN
admet-292	1255	2	pharmscitech	pharmscitech	VERB
admet-292	1255	3	9	9	NUM
admet-292	1255	4	(	(	PUNCT
admet-292	1255	5	2008	2008	NUM
admet-292	1255	6	)	)	PUNCT
admet-292	1255	7	425	425	NUM
admet-292	1255	8	-	-	SYM
admet-292	1255	9	430	430	NUM
admet-292	1255	10	.	.	PUNCT
admet-292	1256	1	[	[	X
admet-292	1256	2	123	123	NUM
admet-292	1256	3	]	]	PUNCT
admet-292	1256	4	k.	k.	PROPN
admet-292	1256	5	beattie	beattie	PROPN
admet-292	1256	6	,	,	PUNCT
admet-292	1256	7	g.	g.	PROPN
admet-292	1256	8	phadke	phadke	PROPN
admet-292	1256	9	,	,	PUNCT
admet-292	1256	10	j.	j.	PROPN
admet-292	1256	11	novakovic	novakovic	PROPN
admet-292	1256	12	.	.	PUNCT
admet-292	1257	1	profiles	profile	NOUN
admet-292	1257	2	drug	drug	NOUN
admet-292	1257	3	subst	subst	NOUN
admet-292	1257	4	.	.	PUNCT
admet-292	1258	1	excip	excip	NOUN
admet-292	1258	2	.	.	PUNCT
admet-292	1259	1	rel	rel	PROPN
admet-292	1259	2	.	.	PROPN
admet-292	1259	3	method	method	PROPN
admet-292	1259	4	.	.	PUNCT
admet-292	1260	1	38	38	NUM
admet-292	1260	2	(	(	PUNCT
admet-292	1260	3	2013	2013	NUM
admet-292	1260	4	)	)	PUNCT
admet-292	1260	5	113	113	NUM
admet-292	1260	6	-	-	SYM
admet-292	1260	7	157	157	NUM
admet-292	1260	8	.	.	PUNCT
admet-292	1261	1	[	[	X
admet-292	1261	2	124	124	NUM
admet-292	1261	3	]	]	PUNCT
admet-292	1261	4	y.-l	y.-l	NOUN
admet-292	1261	5	.	.	PUNCT
admet-292	1262	1	hsieh	hsieh	PROPN
admet-292	1262	2	,	,	PUNCT
admet-292	1262	3	g.a	g.a	PROPN
admet-292	1262	4	.	.	PROPN
admet-292	1262	5	ilevbare	ilevbare	PROPN
admet-292	1262	6	,	,	PUNCT
admet-292	1262	7	b.	b.	PROPN
admet-292	1262	8	van	van	PROPN
admet-292	1262	9	eerdenbrugh	eerdenbrugh	PROPN
admet-292	1262	10	,	,	PUNCT
admet-292	1262	11	k.j	k.j	PROPN
admet-292	1262	12	.	.	PROPN
admet-292	1262	13	box	box	PROPN
admet-292	1262	14	,	,	PUNCT
admet-292	1262	15	m.v	m.v	PROPN
admet-292	1262	16	.	.	PROPN
admet-292	1262	17	sanchez	sanchez	PROPN
admet-292	1262	18	-	-	PUNCT
admet-292	1262	19	felix	felix	PROPN
admet-292	1262	20	,	,	PUNCT
admet-292	1262	21	l.s	l.s	PROPN
admet-292	1262	22	.	.	PROPN
admet-292	1262	23	taylor	taylor	PROPN
admet-292	1262	24	.	.	PUNCT
admet-292	1263	1	pharm	pharm	PROPN
admet-292	1263	2	.	.	PUNCT
admet-292	1264	1	res	re	NOUN
admet-292	1264	2	.	.	PROPN
admet-292	1265	1	29	29	NUM
admet-292	1265	2	(	(	PUNCT
admet-292	1265	3	2012	2012	NUM
admet-292	1265	4	)	)	PUNCT
admet-292	1265	5	2738	2738	NUM
admet-292	1265	6	-	-	SYM
admet-292	1265	7	2753	2753	NUM
admet-292	1265	8	.	.	PUNCT
admet-292	1266	1	[	[	X
admet-292	1266	2	125	125	NUM
admet-292	1266	3	]	]	PUNCT
admet-292	1266	4	s.	s.	PROPN
admet-292	1266	5	clarysse	clarysse	PROPN
admet-292	1266	6	,	,	PUNCT
admet-292	1266	7	j.	j.	PROPN
admet-292	1266	8	brouwers	brouwers	PROPN
admet-292	1266	9	,	,	PUNCT
admet-292	1266	10	j.	j.	PROPN
admet-292	1266	11	tack	tack	PROPN
admet-292	1266	12	,	,	PUNCT
admet-292	1266	13	p.	p.	PROPN
admet-292	1266	14	annaert	annaert	NOUN
admet-292	1266	15	,	,	PUNCT
admet-292	1266	16	p.	p.	NOUN
admet-292	1266	17	augustijns	augustijns	NOUN
admet-292	1266	18	.	.	PUNCT
admet-292	1267	1	eur	eur	PROPN
admet-292	1267	2	.	.	PUNCT
admet-292	1268	1	j.	j.	PROPN
admet-292	1268	2	pharm	pharm	PROPN
admet-292	1268	3	.	.	PUNCT
admet-292	1269	1	sci	sci	PROPN
admet-292	1269	2	.	.	PROPN
admet-292	1270	1	43	43	NUM
admet-292	1270	2	(	(	PUNCT
admet-292	1270	3	2011	2011	NUM
admet-292	1270	4	)	)	PUNCT
admet-292	1270	5	260	260	NUM
admet-292	1270	6	-	-	SYM
admet-292	1270	7	269	269	NUM
admet-292	1270	8	.	.	PUNCT
admet-292	1271	1	[	[	X
admet-292	1271	2	126	126	NUM
admet-292	1271	3	]	]	X
admet-292	1271	4	s.r	s.r	PROPN
admet-292	1271	5	.	.	PROPN
admet-292	1271	6	johnson	johnson	PROPN
admet-292	1271	7	,	,	PUNCT
admet-292	1271	8	x.q	x.q	PROPN
admet-292	1271	9	.	.	PROPN
admet-292	1271	10	chen	chen	PROPN
admet-292	1271	11	,	,	PUNCT
admet-292	1271	12	d.	d.	PROPN
admet-292	1271	13	murphy	murphy	PROPN
admet-292	1271	14	,	,	PUNCT
admet-292	1271	15	o.	o.	PROPN
admet-292	1271	16	gudmundsson	gudmundsson	PROPN
admet-292	1271	17	.	.	PUNCT
admet-292	1272	1	mol	mol	PROPN
admet-292	1272	2	.	.	PROPN
admet-292	1272	3	pharmaceut	pharmaceut	PROPN
admet-292	1272	4	.	.	PUNCT
admet-292	1273	1	4	4	NUM
admet-292	1273	2	(	(	PUNCT
admet-292	1273	3	2007	2007	NUM
admet-292	1273	4	)	)	PUNCT
admet-292	1273	5	513	513	NUM
admet-292	1273	6	-	-	SYM
admet-292	1273	7	523	523	NUM
admet-292	1273	8	.	.	PUNCT
admet-292	1274	1	[	[	X
admet-292	1274	2	127	127	NUM
admet-292	1274	3	]	]	PUNCT
admet-292	1274	4	a.	a.	NOUN
admet-292	1274	5	glomme	glomme	PROPN
admet-292	1274	6	,	,	PUNCT
admet-292	1274	7	et	et	PROPN
admet-292	1274	8	al	al	PROPN
admet-292	1274	9	.	.	PUNCT
admet-292	1275	1	in	in	ADP
admet-292	1275	2	:	:	PUNCT
admet-292	1275	3	b.	b.	PROPN
admet-292	1275	4	testa	testa	PROPN
admet-292	1275	5	,	,	PUNCT
admet-292	1275	6	et	et	PROPN
admet-292	1275	7	al	al	PROPN
admet-292	1275	8	.	.	PUNCT
admet-292	1275	9	(	(	PUNCT
admet-292	1275	10	eds	ed	NOUN
admet-292	1275	11	)	)	PUNCT
admet-292	1275	12	,	,	PUNCT
admet-292	1275	13	pharmacokinetic	pharmacokinetic	ADJ
admet-292	1275	14	profiling	profiling	NOUN
admet-292	1275	15	in	in	ADP
admet-292	1275	16	drug	drug	NOUN
admet-292	1275	17	research	research	NOUN
admet-292	1275	18	.	.	PUNCT
admet-292	1276	1	wiley	wiley	PROPN
admet-292	1276	2	-	-	PUNCT
admet-292	1276	3	vch	vch	PROPN
admet-292	1276	4	2006	2006	NUM
admet-292	1276	5	,	,	PUNCT
admet-292	1276	6	pp	pp	ADP
admet-292	1276	7	259	259	NUM
admet-292	1276	8	-	-	SYM
admet-292	1276	9	280	280	NUM
admet-292	1276	10	.	.	PUNCT
admet-292	1277	1	[	[	X
admet-292	1277	2	128	128	NUM
admet-292	1277	3	]	]	PUNCT
admet-292	1277	4	v.	v.	ADP
admet-292	1277	5	bakatselou	bakatselou	PROPN
admet-292	1277	6	,	,	PUNCT
admet-292	1277	7	r.c	r.c	PROPN
admet-292	1277	8	.	.	PROPN
admet-292	1277	9	oppenheim	oppenheim	PROPN
admet-292	1277	10	,	,	PUNCT
admet-292	1277	11	j.b	j.b	PROPN
admet-292	1277	12	.	.	PROPN
admet-292	1277	13	dressman	dressman	PROPN
admet-292	1277	14	.	.	PUNCT
admet-292	1278	1	pharm	pharm	PROPN
admet-292	1278	2	.	.	PUNCT
admet-292	1279	1	res	re	NOUN
admet-292	1279	2	.	.	PROPN
admet-292	1279	3	8	8	NUM
admet-292	1279	4	(	(	PUNCT
admet-292	1279	5	1991	1991	NUM
admet-292	1279	6	)	)	PUNCT
admet-292	1279	7	1461	1461	NUM
admet-292	1279	8	-	-	SYM
admet-292	1279	9	1469	1469	NUM
admet-292	1279	10	.	.	PUNCT
admet-292	1280	1	[	[	X
admet-292	1280	2	129	129	NUM
admet-292	1280	3	]	]	X
admet-292	1280	4	s.d	s.d	PROPN
admet-292	1280	5	.	.	PROPN
admet-292	1280	6	mithani	mithani	PROPN
admet-292	1280	7	,	,	PUNCT
admet-292	1280	8	r.c	r.c	PROPN
admet-292	1280	9	.	.	PROPN
admet-292	1280	10	oppenheim	oppenheim	PROPN
admet-292	1280	11	,	,	PUNCT
admet-292	1280	12	j.b	j.b	PROPN
admet-292	1280	13	.	.	PROPN
admet-292	1280	14	dressman	dressman	PROPN
admet-292	1280	15	.	.	PUNCT
admet-292	1281	1	pharm	pharm	PROPN
admet-292	1281	2	.	.	PUNCT
admet-292	1282	1	res	re	NOUN
admet-292	1282	2	.	.	PROPN
admet-292	1282	3	13	13	NUM
admet-292	1282	4	(	(	PUNCT
admet-292	1282	5	1996	1996	NUM
admet-292	1282	6	)	)	PUNCT
admet-292	1282	7	163	163	NUM
admet-292	1282	8	-	-	SYM
admet-292	1282	9	167	167	NUM
admet-292	1282	10	.	.	PUNCT
admet-292	1283	1	[	[	X
admet-292	1283	2	130	130	NUM
admet-292	1283	3	]	]	X
admet-292	1283	4	l.-a	l.-a	NOUN
admet-292	1283	5	.	.	PUNCT
admet-292	1284	1	erlich	erlich	PROPN
admet-292	1284	2	,	,	PUNCT
admet-292	1284	3	d.	d.	PROPN
admet-292	1284	4	yu	yu	PROPN
admet-292	1284	5	,	,	PUNCT
admet-292	1284	6	d.a	d.a	PROPN
admet-292	1284	7	.	.	PROPN
admet-292	1284	8	pallister	pallister	PROPN
admet-292	1284	9	,	,	PUNCT
admet-292	1284	10	r.	r.	PROPN
admet-292	1284	11	saul	saul	PROPN
admet-292	1284	12	levinson	levinson	PROPN
admet-292	1284	13	,	,	PUNCT
admet-292	1284	14	d.g	d.g	PROPN
admet-292	1284	15	.	.	PROPN
admet-292	1284	16	gole	gole	PROPN
admet-292	1284	17	,	,	PUNCT
admet-292	1284	18	p.a	p.a	PROPN
admet-292	1284	19	.	.	PROPN
admet-292	1284	20	wilkinson	wilkinson	PROPN
admet-292	1284	21	,	,	PUNCT
admet-292	1284	22	r.e	r.e	PROPN
admet-292	1284	23	.	.	PROPN
admet-292	1284	24	erlich	erlich	PROPN
admet-292	1284	25	,	,	PUNCT
admet-292	1284	26	l.e	l.e	PROPN
admet-292	1284	27	.	.	PROPN
admet-292	1284	28	reeve	reeve	PROPN
admet-292	1284	29	,	,	PUNCT
admet-292	1284	30	t.x	t.x	PROPN
admet-292	1284	31	.	.	PROPN
admet-292	1284	32	viegas	viegas	PROPN
admet-292	1284	33	.	.	PUNCT
admet-292	1285	1	int	int	NOUN
admet-292	1285	2	.	.	PUNCT
admet-292	1286	1	j.	j.	PROPN
admet-292	1286	2	pharm	pharm	PROPN
admet-292	1286	3	.	.	PUNCT
admet-292	1287	1	179	179	NUM
admet-292	1287	2	(	(	PUNCT
admet-292	1287	3	1999	1999	NUM
admet-292	1287	4	)	)	PUNCT
admet-292	1287	5	49	49	NUM
admet-292	1287	6	-	-	SYM
admet-292	1287	7	53	53	NUM
admet-292	1287	8	.	.	PUNCT
admet-292	1288	1	[	[	X
admet-292	1288	2	131	131	NUM
admet-292	1288	3	]	]	PUNCT
admet-292	1288	4	c.a.s	c.a.s	PROPN
admet-292	1288	5	.	.	PROPN
admet-292	1288	6	bergström	bergström	PROPN
admet-292	1288	7	,	,	PUNCT
admet-292	1288	8	c.m	c.m	PROPN
admet-292	1288	9	.	.	PROPN
admet-292	1288	10	wassvik	wassvik	PROPN
admet-292	1288	11	,	,	PUNCT
admet-292	1288	12	u.	u.	PROPN
admet-292	1288	13	norinder	norinder	PROPN
admet-292	1288	14	,	,	PUNCT
admet-292	1288	15	k.	k.	PROPN
admet-292	1288	16	luthman	luthman	PROPN
admet-292	1288	17	,	,	PUNCT
admet-292	1288	18	p.	p.	PROPN
admet-292	1288	19	artursson	artursson	PROPN
admet-292	1288	20	.	.	PUNCT
admet-292	1289	1	j.	j.	PROPN
admet-292	1289	2	chem	chem	PROPN
admet-292	1289	3	.	.	PUNCT
admet-292	1290	1	inf	inf	PROPN
admet-292	1290	2	.	.	PUNCT
admet-292	1290	3	comput	comput	PROPN
admet-292	1290	4	.	.	PUNCT
admet-292	1291	1	sci	sci	PROPN
admet-292	1291	2	.	.	PROPN
admet-292	1292	1	44	44	NUM
admet-292	1292	2	(	(	PUNCT
admet-292	1292	3	2004	2004	NUM
admet-292	1292	4	)	)	PUNCT
admet-292	1292	5	1477	1477	NUM
admet-292	1292	6	-	-	SYM
admet-292	1292	7	1488	1488	NUM
admet-292	1292	8	.	.	PUNCT
admet-292	1293	1	[	[	X
admet-292	1293	2	132	132	NUM
admet-292	1293	3	]	]	X
admet-292	1293	4	s.a	s.a	PROPN
admet-292	1293	5	.	.	PROPN
admet-292	1293	6	raina	raina	PROPN
admet-292	1293	7	,	,	PUNCT
admet-292	1293	8	b.	b.	PROPN
admet-292	1293	9	van	van	PROPN
admet-292	1293	10	eerdenbrugh	eerdenbrugh	PROPN
admet-292	1293	11	,	,	PUNCT
admet-292	1293	12	d.e	d.e	PROPN
admet-292	1293	13	.	.	PROPN
admet-292	1293	14	alonzo	alonzo	PROPN
admet-292	1293	15	,	,	PUNCT
admet-292	1293	16	h.	h.	PROPN
admet-292	1293	17	mo	mo	PROPN
admet-292	1293	18	,	,	PUNCT
admet-292	1293	19	g.g.z	g.g.z	PROPN
admet-292	1293	20	.	.	PUNCT
admet-292	1294	1	zhang	zhang	PROPN
admet-292	1294	2	,	,	PUNCT
admet-292	1294	3	y.gao	y.gao	PROPN
admet-292	1294	4	,	,	PUNCT
admet-292	1294	5	l.s	l.s	PROPN
admet-292	1294	6	.	.	PROPN
admet-292	1294	7	taylor	taylor	PROPN
admet-292	1294	8	.	.	PUNCT
admet-292	1295	1	j.	j.	PROPN
admet-292	1295	2	pharm	pharm	PROPN
admet-292	1295	3	.	.	PUNCT
admet-292	1296	1	sci	sci	PROPN
admet-292	1296	2	.	.	PROPN
admet-292	1297	1	104	104	NUM
admet-292	1297	2	(	(	PUNCT
admet-292	1297	3	2015	2015	NUM
admet-292	1297	4	)	)	PUNCT
admet-292	1297	5	,	,	PUNCT
admet-292	1297	6	1981	1981	NUM
admet-292	1297	7	-	-	SYM
admet-292	1297	8	1992	1992	NUM
admet-292	1297	9	.	.	PUNCT
admet-292	1298	1	[	[	X
admet-292	1298	2	133	133	NUM
admet-292	1298	3	]	]	PUNCT
admet-292	1298	4	t.	t.	PROPN
admet-292	1298	5	taupitz	taupitz	PROPN
admet-292	1298	6	,	,	PUNCT
admet-292	1298	7	j.b	j.b	PROPN
admet-292	1298	8	.	.	PROPN
admet-292	1298	9	dressman	dressman	PROPN
admet-292	1298	10	,	,	PUNCT
admet-292	1298	11	s.	s.	PROPN
admet-292	1298	12	klein	klein	PROPN
admet-292	1298	13	.	.	PUNCT
admet-292	1299	1	eur	eur	PROPN
admet-292	1299	2	.	.	PUNCT
admet-292	1300	1	j.	j.	PROPN
admet-292	1300	2	pharm	pharm	PROPN
admet-292	1300	3	.	.	PUNCT
admet-292	1301	1	biopharm	biopharm	PROPN
admet-292	1301	2	.	.	PUNCT
admet-292	1302	1	84	84	NUM
admet-292	1302	2	(	(	PUNCT
admet-292	1302	3	2013	2013	NUM
admet-292	1302	4	)	)	PUNCT
admet-292	1302	5	208	208	NUM
admet-292	1302	6	-	-	SYM
admet-292	1302	7	218	218	NUM
admet-292	1302	8	.	.	PUNCT
admet-292	1303	1	[	[	X
admet-292	1303	2	134	134	NUM
admet-292	1303	3	]	]	X
admet-292	1303	4	l.y	l.y	PROPN
admet-292	1303	5	.	.	PROPN
admet-292	1303	6	narasimham	narasimham	PROPN
admet-292	1303	7	,	,	PUNCT
admet-292	1303	8	v.d	v.d	PROPN
admet-292	1303	9	.	.	PROPN
admet-292	1303	10	barhate	barhate	PROPN
admet-292	1303	11	.	.	PUNCT
admet-292	1304	1	j.	j.	PROPN
admet-292	1304	2	pharmacy	pharmacy	PROPN
admet-292	1304	3	res	re	NOUN
admet-292	1304	4	.	.	PROPN
admet-292	1304	5	4	4	NUM
admet-292	1304	6	(	(	PUNCT
admet-292	1304	7	2011	2011	NUM
admet-292	1304	8	)	)	PUNCT
admet-292	1304	9	532	532	NUM
admet-292	1304	10	-	-	SYM
admet-292	1304	11	536	536	NUM
admet-292	1304	12	.	.	PUNCT
admet-292	1305	1	admet	admet	PROPN
admet-292	1305	2	&	&	CCONJ
admet-292	1305	3	dmpk	dmpk	PROPN
admet-292	1305	4	4(2	4(2	NUM
admet-292	1305	5	)	)	PUNCT
admet-292	1305	6	(	(	PUNCT
admet-292	1305	7	2016	2016	NUM
admet-292	1305	8	)	)	PUNCT
admet-292	1305	9	117	117	NUM
admet-292	1305	10	-	-	SYM
admet-292	1305	11	178	178	NUM
admet-292	1305	12	consensus	consensus	NOUN
admet-292	1305	13	recommendations	recommendation	NOUN
admet-292	1305	14	for	for	ADP
admet-292	1305	15	improving	improve	VERB
admet-292	1305	16	solubility	solubility	NOUN
admet-292	1305	17	-	-	PUNCT
admet-292	1305	18	ph	ph	ADJ
admet-292	1305	19	data	datum	NOUN
admet-292	1305	20	quality	quality	NOUN
admet-292	1305	21	doi	doi	NOUN
admet-292	1305	22	:	:	PUNCT
admet-292	1305	23	10.5599	10.5599	NUM
admet-292	1305	24	/	/	SYM
admet-292	1305	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1305	26	161	161	NUM
admet-292	1305	27	[	[	SYM
admet-292	1305	28	135	135	NUM
admet-292	1305	29	]	]	PUNCT
admet-292	1305	30	s.	s.	PROPN
admet-292	1305	31	grbić	grbić	PROPN
admet-292	1305	32	,	,	PUNCT
admet-292	1305	33	j.	j.	PROPN
admet-292	1305	34	parojčić	parojčić	PROPN
admet-292	1305	35	,	,	PUNCT
admet-292	1305	36	a.	a.	NOUN
admet-292	1305	37	malenović	malenović	PROPN
admet-292	1305	38	,	,	PUNCT
admet-292	1305	39	z.	z.	PROPN
admet-292	1305	40	djurić	djurić	PROPN
admet-292	1305	41	,	,	PUNCT
admet-292	1305	42	m.	m.	NOUN
admet-292	1305	43	maksimović	maksimović	PROPN
admet-292	1305	44	.	.	PUNCT
admet-292	1306	1	j.	j.	PROPN
admet-292	1306	2	chem	chem	PROPN
admet-292	1306	3	.	.	PUNCT
admet-292	1307	1	eng	eng	PROPN
admet-292	1307	2	.	.	PROPN
admet-292	1307	3	data	data	PROPN
admet-292	1307	4	55	55	NUM
admet-292	1307	5	(	(	PUNCT
admet-292	1307	6	2010	2010	NUM
admet-292	1307	7	)	)	PUNCT
admet-292	1307	8	1368	1368	NUM
admet-292	1307	9	-	-	SYM
admet-292	1307	10	1371	1371	NUM
admet-292	1307	11	.	.	PUNCT
admet-292	1308	1	[	[	X
admet-292	1308	2	136	136	NUM
admet-292	1308	3	]	]	X
admet-292	1308	4	j.h	j.h	PROPN
admet-292	1308	5	.	.	PROPN
admet-292	1308	6	fagerberg	fagerberg	PROPN
admet-292	1308	7	,	,	PUNCT
admet-292	1308	8	e.	e.	PROPN
admet-292	1308	9	karlsson	karlsson	PROPN
admet-292	1308	10	,	,	PUNCT
admet-292	1308	11	j.	j.	PROPN
admet-292	1308	12	ulander	ulander	PROPN
admet-292	1308	13	,	,	PUNCT
admet-292	1308	14	g.	g.	PROPN
admet-292	1308	15	hanisch	hanisch	PROPN
admet-292	1308	16	,	,	PUNCT
admet-292	1308	17	c.a.s	c.a.	VERB
admet-292	1308	18	.	.	PUNCT
admet-292	1308	19	bergström	bergström	NOUN
admet-292	1308	20	.	.	PUNCT
admet-292	1309	1	pharm	pharm	PROPN
admet-292	1309	2	.	.	PUNCT
admet-292	1310	1	res	re	NOUN
admet-292	1310	2	.	.	PUNCT
admet-292	1311	1	32	32	NUM
admet-292	1311	2	(	(	PUNCT
admet-292	1311	3	2014	2014	NUM
admet-292	1311	4	)	)	PUNCT
admet-292	1311	5	578	578	NUM
admet-292	1311	6	-	-	SYM
admet-292	1311	7	589	589	NUM
admet-292	1311	8	.	.	PUNCT
admet-292	1312	1	[	[	X
admet-292	1312	2	137	137	NUM
admet-292	1312	3	]	]	PUNCT
admet-292	1312	4	c.a.s	c.a.s	PROPN
admet-292	1312	5	.	.	PROPN
admet-292	1312	6	bergström	bergström	NOUN
admet-292	1312	7	,	,	PUNCT
admet-292	1312	8	m.	m.	NOUN
admet-292	1312	9	strafford	strafford	PROPN
admet-292	1312	10	,	,	PUNCT
admet-292	1312	11	l.	l.	PROPN
admet-292	1312	12	lazorova	lazorova	PROPN
admet-292	1312	13	,	,	PUNCT
admet-292	1312	14	a.	a.	PROPN
admet-292	1312	15	avdeef	avdeef	PROPN
admet-292	1312	16	,	,	PUNCT
admet-292	1312	17	k.	k.	PROPN
admet-292	1312	18	luthman	luthman	PROPN
admet-292	1312	19	,	,	PUNCT
admet-292	1312	20	p.	p.	PROPN
admet-292	1312	21	artursson	artursson	PROPN
admet-292	1312	22	.	.	PUNCT
admet-292	1313	1	j.	j.	PROPN
admet-292	1313	2	med	med	PROPN
admet-292	1313	3	.	.	PROPN
admet-292	1313	4	chem	chem	PROPN
admet-292	1313	5	.	.	PUNCT
admet-292	1314	1	46	46	NUM
admet-292	1314	2	(	(	PUNCT
admet-292	1314	3	2003	2003	NUM
admet-292	1314	4	)	)	PUNCT
admet-292	1314	5	558	558	NUM
admet-292	1314	6	-	-	SYM
admet-292	1314	7	570	570	NUM
admet-292	1314	8	.	.	PUNCT
admet-292	1315	1	[	[	X
admet-292	1315	2	138	138	NUM
admet-292	1315	3	]	]	X
admet-292	1315	4	c.m	c.m	PROPN
admet-292	1315	5	.	.	PROPN
admet-292	1315	6	wassvik	wassvik	PROPN
admet-292	1315	7	,	,	PUNCT
admet-292	1315	8	a.g	a.g	PROPN
admet-292	1315	9	.	.	PROPN
admet-292	1315	10	holmén	holmén	PROPN
admet-292	1315	11	,	,	PUNCT
admet-292	1315	12	c.a.s	c.a.	VERB
admet-292	1315	13	.	.	PROPN
admet-292	1315	14	bergström	bergström	PROPN
admet-292	1315	15	,	,	PUNCT
admet-292	1315	16	i.	i.	PROPN
admet-292	1315	17	zamora	zamora	PROPN
admet-292	1315	18	,	,	PUNCT
admet-292	1315	19	p.	p.	PROPN
admet-292	1315	20	artursson	artursson	PROPN
admet-292	1315	21	.	.	PUNCT
admet-292	1316	1	eur	eur	PROPN
admet-292	1316	2	.	.	PUNCT
admet-292	1317	1	j.	j.	PROPN
admet-292	1317	2	pharm	pharm	PROPN
admet-292	1317	3	.	.	PUNCT
admet-292	1318	1	sci	sci	PROPN
admet-292	1318	2	.	.	PROPN
admet-292	1318	3	29	29	NUM
admet-292	1318	4	(	(	PUNCT
admet-292	1318	5	2006	2006	NUM
admet-292	1318	6	)	)	PUNCT
admet-292	1318	7	294305	294305	NUM
admet-292	1318	8	.	.	PUNCT
admet-292	1319	1	[	[	X
admet-292	1319	2	139	139	NUM
admet-292	1319	3	]	]	X
admet-292	1319	4	j.h	j.h	PROPN
admet-292	1319	5	.	.	PROPN
admet-292	1319	6	fagerberg	fagerberg	PROPN
admet-292	1319	7	,	,	PUNCT
admet-292	1319	8	o.	o.	PROPN
admet-292	1319	9	tsinman	tsinman	NOUN
admet-292	1319	10	,	,	PUNCT
admet-292	1319	11	n.	n.	PROPN
admet-292	1319	12	sun	sun	PROPN
admet-292	1319	13	,	,	PUNCT
admet-292	1319	14	k.	k.	PROPN
admet-292	1319	15	tsinman	tsinman	PROPN
admet-292	1319	16	,	,	PUNCT
admet-292	1319	17	a.	a.	PROPN
admet-292	1319	18	avdeef	avdeef	PROPN
admet-292	1319	19	,	,	PUNCT
admet-292	1319	20	c.a.s	c.a.	VERB
admet-292	1319	21	.	.	PROPN
admet-292	1319	22	bergström	bergström	PROPN
admet-292	1319	23	.	.	PUNCT
admet-292	1320	1	mol	mol	PROPN
admet-292	1320	2	.	.	PROPN
admet-292	1320	3	pharmaceut	pharmaceut	PROPN
admet-292	1320	4	.	.	PUNCT
admet-292	1321	1	7	7	NUM
admet-292	1321	2	(	(	PUNCT
admet-292	1321	3	2010	2010	NUM
admet-292	1321	4	)	)	PUNCT
admet-292	1321	5	1419	1419	NUM
admet-292	1321	6	-	-	SYM
admet-292	1321	7	1430	1430	NUM
admet-292	1321	8	.	.	PUNCT
admet-292	1322	1	[	[	X
admet-292	1322	2	140	140	NUM
admet-292	1322	3	]	]	X
admet-292	1322	4	g.	g.	PROPN
admet-292	1322	5	ottaviani	ottaviani	PROPN
admet-292	1322	6	,	,	PUNCT
admet-292	1322	7	s.	s.	PROPN
admet-292	1322	8	wendelspiess	wendelspiess	PROPN
admet-292	1322	9	,	,	PUNCT
admet-292	1322	10	r.	r.	PROPN
admet-292	1322	11	alvarez	alvarez	PROPN
admet-292	1322	12	-	-	PUNCT
admet-292	1322	13	sánchez	sánchez	PROPN
admet-292	1322	14	.	.	PUNCT
admet-292	1323	1	mol	mol	PROPN
admet-292	1323	2	.	.	PROPN
admet-292	1323	3	pharmaceut	pharmaceut	PROPN
admet-292	1323	4	.	.	PUNCT
admet-292	1324	1	12	12	NUM
admet-292	1324	2	(	(	PUNCT
admet-292	1324	3	2015	2015	NUM
admet-292	1324	4	)	)	PUNCT
admet-292	1324	5	1171	1171	NUM
admet-292	1324	6	-	-	SYM
admet-292	1324	7	1179	1179	NUM
admet-292	1324	8	.	.	PUNCT
admet-292	1325	1	[	[	X
admet-292	1325	2	141	141	NUM
admet-292	1325	3	]	]	PUNCT
admet-292	1325	4	a.	a.	NOUN
admet-292	1325	5	avdeef	avdeef	PROPN
admet-292	1325	6	,	,	PUNCT
admet-292	1325	7	c.m	c.m	PROPN
admet-292	1325	8	.	.	PROPN
admet-292	1325	9	berger	berger	PROPN
admet-292	1325	10	.	.	PUNCT
admet-292	1326	1	eur	eur	PROPN
admet-292	1326	2	.	.	PUNCT
admet-292	1327	1	j.	j.	PROPN
admet-292	1327	2	pharm	pharm	PROPN
admet-292	1327	3	.	.	PUNCT
admet-292	1328	1	sci	sci	PROPN
admet-292	1328	2	.	.	PROPN
admet-292	1329	1	14	14	NUM
admet-292	1329	2	(	(	PUNCT
admet-292	1329	3	2001	2001	NUM
admet-292	1329	4	)	)	PUNCT
admet-292	1329	5	281	281	NUM
admet-292	1329	6	-	-	SYM
admet-292	1329	7	291	291	NUM
admet-292	1329	8	.	.	PUNCT
admet-292	1330	1	[	[	X
admet-292	1330	2	142	142	NUM
admet-292	1330	3	]	]	X
admet-292	1330	4	k.j	k.j	PROPN
admet-292	1330	5	.	.	PROPN
admet-292	1330	6	box	box	PROPN
admet-292	1330	7	,	,	PUNCT
admet-292	1330	8	j.e.a	j.e.a	PROPN
admet-292	1330	9	.	.	PUNCT
admet-292	1330	10	comer	comer	PROPN
admet-292	1330	11	.	.	PUNCT
admet-292	1331	1	curr	curr	PROPN
admet-292	1331	2	.	.	PUNCT
admet-292	1331	3	drug	drug	PROPN
admet-292	1331	4	metab	metab	NOUN
admet-292	1331	5	.	.	PUNCT
admet-292	1332	1	9	9	NUM
admet-292	1332	2	(	(	PUNCT
admet-292	1332	3	2008	2008	NUM
admet-292	1332	4	)	)	PUNCT
admet-292	1332	5	869	869	NUM
admet-292	1332	6	-	-	SYM
admet-292	1332	7	878	878	NUM
admet-292	1332	8	.	.	PUNCT
admet-292	1333	1	[	[	X
admet-292	1333	2	143	143	NUM
admet-292	1333	3	]	]	X
admet-292	1333	4	c.	c.	NOUN
admet-292	1333	5	sköld	sköld	NOUN
admet-292	1333	6	,	,	PUNCT
admet-292	1333	7	s.	s.	PROPN
admet-292	1333	8	winiwarter	winiwarter	PROPN
admet-292	1333	9	,	,	PUNCT
admet-292	1333	10	j.	j.	PROPN
admet-292	1333	11	wernevik	wernevik	PROPN
admet-292	1333	12	,	,	PUNCT
admet-292	1333	13	f.	f.	PROPN
admet-292	1333	14	bergström	bergström	PROPN
admet-292	1333	15	,	,	PUNCT
admet-292	1333	16	l.	l.	PROPN
admet-292	1333	17	engström	engström	PROPN
admet-292	1333	18	,	,	PUNCT
admet-292	1333	19	r.	r.	PROPN
admet-292	1333	20	allen	allen	PROPN
admet-292	1333	21	,	,	PUNCT
admet-292	1333	22	k.	k.	PROPN
admet-292	1333	23	box	box	PROPN
admet-292	1333	24	,	,	PUNCT
admet-292	1333	25	j.	j.	PROPN
admet-292	1333	26	comer	comer	PROPN
admet-292	1333	27	,	,	PUNCT
admet-292	1333	28	j.	j.	PROPN
admet-292	1333	29	mole	mole	PROPN
admet-292	1333	30	,	,	PUNCT
admet-292	1333	31	a.	a.	PROPN
admet-292	1333	32	hallberg	hallberg	PROPN
admet-292	1333	33	,	,	PUNCT
admet-292	1333	34	h.	h.	PROPN
admet-292	1333	35	lennernäs	lennernäs	PROPN
admet-292	1333	36	,	,	PUNCT
admet-292	1333	37	t.	t.	PROPN
admet-292	1333	38	lundstedt	lundstedt	PROPN
admet-292	1333	39	,	,	PUNCT
admet-292	1333	40	a.-l	a.-l	PROPN
admet-292	1333	41	.	.	PUNCT
admet-292	1334	1	ungell	ungell	PROPN
admet-292	1334	2	,	,	PUNCT
admet-292	1334	3	a.	a.	NOUN
admet-292	1334	4	karlén	karlén	PROPN
admet-292	1334	5	.	.	PUNCT
admet-292	1335	1	j.	j.	PROPN
admet-292	1335	2	med	med	PROPN
admet-292	1335	3	.	.	PROPN
admet-292	1335	4	chem	chem	PROPN
admet-292	1335	5	.	.	PUNCT
admet-292	1336	1	49	49	NUM
admet-292	1336	2	(	(	PUNCT
admet-292	1336	3	2006	2006	NUM
admet-292	1336	4	)	)	PUNCT
admet-292	1336	5	6660	6660	NUM
admet-292	1336	6	-	-	SYM
admet-292	1336	7	6671	6671	NUM
admet-292	1336	8	.	.	PUNCT
admet-292	1337	1	[	[	X
admet-292	1337	2	144	144	NUM
admet-292	1337	3	]	]	X
admet-292	1337	4	w.h	w.h	PROPN
admet-292	1337	5	.	.	PROPN
admet-292	1337	6	streng	streng	PROPN
admet-292	1337	7	,	,	PUNCT
admet-292	1337	8	s.k	s.k	PROPN
admet-292	1337	9	.	.	PROPN
admet-292	1337	10	hsi	hsi	PROPN
admet-292	1337	11	,	,	PUNCT
admet-292	1337	12	p.e	p.e	PROPN
admet-292	1337	13	.	.	PROPN
admet-292	1337	14	helms	helm	NOUN
admet-292	1337	15	,	,	PUNCT
admet-292	1337	16	h.g.h	h.g.h	NOUN
admet-292	1337	17	.	.	PUNCT
admet-292	1337	18	tan	tan	PROPN
admet-292	1337	19	.	.	PUNCT
admet-292	1338	1	j.	j.	PROPN
admet-292	1338	2	pharm	pharm	PROPN
admet-292	1338	3	.	.	PUNCT
admet-292	1339	1	sci	sci	PROPN
admet-292	1339	2	.	.	PROPN
admet-292	1340	1	73	73	NUM
admet-292	1340	2	(	(	PUNCT
admet-292	1340	3	1984	1984	NUM
admet-292	1340	4	)	)	PUNCT
admet-292	1340	5	1679	1679	NUM
admet-292	1340	6	-	-	SYM
admet-292	1340	7	1684	1684	NUM
admet-292	1340	8	.	.	PUNCT
admet-292	1341	1	[	[	X
admet-292	1341	2	145	145	NUM
admet-292	1341	3	]	]	PUNCT
admet-292	1341	4	b.	b.	PROPN
admet-292	1341	5	bard	bard	PROPN
admet-292	1341	6	,	,	PUNCT
admet-292	1341	7	s.	s.	PROPN
admet-292	1341	8	martel	martel	PROPN
admet-292	1341	9	,	,	PUNCT
admet-292	1341	10	p.-a	p.-a	PROPN
admet-292	1341	11	.	.	PUNCT
admet-292	1342	1	carrupt	carrupt	PROPN
admet-292	1342	2	.	.	PUNCT
admet-292	1343	1	eur	eur	PROPN
admet-292	1343	2	.	.	PUNCT
admet-292	1344	1	j.	j.	PROPN
admet-292	1344	2	pharm	pharm	PROPN
admet-292	1344	3	.	.	PUNCT
admet-292	1345	1	sci	sci	PROPN
admet-292	1345	2	.	.	PROPN
admet-292	1346	1	33	33	NUM
admet-292	1346	2	(	(	PUNCT
admet-292	1346	3	2008	2008	NUM
admet-292	1346	4	)	)	PUNCT
admet-292	1346	5	230	230	NUM
admet-292	1346	6	-	-	SYM
admet-292	1346	7	240	240	NUM
admet-292	1346	8	.	.	PUNCT
admet-292	1347	1	[	[	X
admet-292	1347	2	146	146	NUM
admet-292	1347	3	]	]	X
admet-292	1347	4	s.	s.	PROPN
admet-292	1347	5	budavari	budavari	PROPN
admet-292	1347	6	,	,	PUNCT
admet-292	1347	7	et	et	PROPN
admet-292	1347	8	al	al	PROPN
admet-292	1347	9	.	.	PUNCT
admet-292	1348	1	the	the	DET
admet-292	1348	2	merck	merck	PROPN
admet-292	1348	3	index	index	PROPN
admet-292	1348	4	.	.	PUNCT
admet-292	1349	1	12th	12th	ADJ
admet-292	1349	2	ed	ed	NOUN
admet-292	1349	3	.	.	PROPN
admet-292	1349	4	,	,	PUNCT
admet-292	1350	1	windholz	windholz	NOUN
admet-292	1350	2	m	m	VERB
admet-292	1350	3	(	(	PUNCT
admet-292	1350	4	ed	ed	NOUN
admet-292	1350	5	.	.	PUNCT
admet-292	1350	6	)	)	PUNCT
admet-292	1350	7	rahway	rahway	PROPN
admet-292	1350	8	,	,	PUNCT
admet-292	1350	9	nj	nj	PROPN
admet-292	1350	10	:	:	PUNCT
admet-292	1350	11	merck	merck	PROPN
admet-292	1350	12	and	and	CCONJ
admet-292	1350	13	co.	co.	PROPN
admet-292	1350	14	,	,	PUNCT
admet-292	1350	15	inc	inc	PROPN
admet-292	1350	16	.	.	PROPN
admet-292	1350	17	,	,	PUNCT
admet-292	1350	18	1996	1996	NUM
admet-292	1350	19	.	.	PUNCT
admet-292	1351	1	[	[	X
admet-292	1351	2	147	147	NUM
admet-292	1351	3	]	]	PUNCT
admet-292	1351	4	t.	t.	NOUN
admet-292	1351	5	verbić	verbić	NOUN
admet-292	1351	6	.	.	PUNCT
admet-292	1352	1	abstracts	abstract	NOUN
admet-292	1352	2	.	.	PUNCT
admet-292	1353	1	4th	4th	ADJ
admet-292	1353	2	world	world	NOUN
admet-292	1353	3	conf	conf	NOUN
admet-292	1353	4	.	.	PUNCT
admet-292	1354	1	on	on	ADP
admet-292	1354	2	phys.-chem	phys.-chem	PROPN
admet-292	1354	3	.	.	PUNCT
admet-292	1355	1	meth	meth	NOUN
admet-292	1355	2	.	.	PUNCT
admet-292	1356	1	drug	drug	NOUN
admet-292	1356	2	disc	disc	NOUN
admet-292	1356	3	.	.	PUNCT
admet-292	1357	1	dev	dev	PROPN
admet-292	1357	2	.	.	PUNCT
admet-292	1358	1	(	(	PUNCT
admet-292	1358	2	pcmddd-4	pcmddd-4	NOUN
admet-292	1358	3	)	)	PUNCT
admet-292	1358	4	.	.	PUNCT
admet-292	1359	1	red	red	PROPN
admet-292	1359	2	island	island	PROPN
admet-292	1359	3	,	,	PUNCT
admet-292	1359	4	croatia	croatia	PROPN
admet-292	1359	5	.	.	PUNCT
admet-292	1360	1	21	21	NUM
admet-292	1360	2	-	-	SYM
admet-292	1360	3	24	24	NUM
admet-292	1360	4	sep	sep	PROPN
admet-292	1360	5	2015	2015	NUM
admet-292	1360	6	.	.	PUNCT
admet-292	1361	1	[	[	X
admet-292	1361	2	148	148	NUM
admet-292	1361	3	]	]	X
admet-292	1361	4	e.	e.	PROPN
admet-292	1361	5	nicolaides	nicolaides	PROPN
admet-292	1361	6	,	,	PUNCT
admet-292	1361	7	e.	e.	PROPN
admet-292	1361	8	galia	galia	PROPN
admet-292	1361	9	,	,	PUNCT
admet-292	1361	10	c.	c.	PROPN
admet-292	1361	11	efthymiopoulos	efthymiopoulos	PROPN
admet-292	1361	12	,	,	PUNCT
admet-292	1362	1	j.b	j.b	PROPN
admet-292	1362	2	.	.	PROPN
admet-292	1362	3	dressman	dressman	PROPN
admet-292	1362	4	,	,	PUNCT
admet-292	1362	5	c.	c.	PROPN
admet-292	1362	6	reppas	reppas	PROPN
admet-292	1362	7	.	.	PUNCT
admet-292	1363	1	pharm	pharm	NOUN
admet-292	1363	2	.	.	PUNCT
admet-292	1364	1	res	re	NOUN
admet-292	1364	2	.	.	PUNCT
admet-292	1365	1	16	16	NUM
admet-292	1365	2	(	(	PUNCT
admet-292	1365	3	1999	1999	NUM
admet-292	1365	4	)	)	PUNCT
admet-292	1365	5	1876	1876	NUM
admet-292	1365	6	-	-	SYM
admet-292	1365	7	1882	1882	NUM
admet-292	1365	8	.	.	PUNCT
admet-292	1366	1	[	[	X
admet-292	1366	2	149	149	NUM
admet-292	1366	3	]	]	X
admet-292	1366	4	n.	n.	PROPN
admet-292	1366	5	suzuki	suzuki	PROPN
admet-292	1366	6	,	,	PUNCT
admet-292	1366	7	k.	k.	PROPN
admet-292	1366	8	kasahara	kasahara	PROPN
admet-292	1366	9	,	,	PUNCT
admet-292	1366	10	h.	h.	PROPN
admet-292	1366	11	hasegawa	hasegawa	PROPN
admet-292	1366	12	,	,	PUNCT
admet-292	1366	13	t.	t.	PROPN
admet-292	1366	14	kawasaki	kawasaki	PROPN
admet-292	1366	15	.	.	PUNCT
admet-292	1366	16	int	int	PROPN
admet-292	1366	17	.	.	PUNCT
admet-292	1367	1	j.	j.	PROPN
admet-292	1367	2	pharm	pharm	PROPN
admet-292	1367	3	.	.	PUNCT
admet-292	1368	1	248	248	NUM
admet-292	1368	2	(	(	PUNCT
admet-292	1368	3	2002	2002	NUM
admet-292	1368	4	)	)	PUNCT
admet-292	1368	5	71	71	NUM
admet-292	1368	6	-	-	SYM
admet-292	1368	7	80	80	NUM
admet-292	1368	8	.	.	PUNCT
admet-292	1369	1	[	[	X
admet-292	1369	2	150	150	NUM
admet-292	1369	3	]	]	PUNCT
admet-292	1369	4	g.	g.	PROPN
admet-292	1369	5	völgyi	völgyi	PROPN
admet-292	1369	6	,	,	PUNCT
admet-292	1369	7	k.	k.	PROPN
admet-292	1369	8	takács	takács	PROPN
admet-292	1369	9	-	-	PUNCT
admet-292	1369	10	novák	novák	NOUN
admet-292	1369	11	.	.	PUNCT
admet-292	1369	12	filtration	filtration	NOUN
admet-292	1369	13	as	as	ADP
admet-292	1369	14	phase	phase	NOUN
admet-292	1369	15	separation	separation	NOUN
admet-292	1369	16	technique	technique	NOUN
admet-292	1369	17	in	in	ADP
admet-292	1369	18	saturation	saturation	NOUN
admet-292	1369	19	shake	shake	NOUN
admet-292	1369	20	-	-	PUNCT
admet-292	1369	21	flask	flask	NOUN
admet-292	1369	22	solubility	solubility	NOUN
admet-292	1369	23	determination	determination	NOUN
admet-292	1369	24	method	method	NOUN
admet-292	1369	25	.	.	PUNCT
admet-292	1370	1	abstracts	abstract	NOUN
admet-292	1370	2	–	–	PUNCT
admet-292	1370	3	4th	4th	ADJ
admet-292	1370	4	world	world	NOUN
admet-292	1370	5	conf	conf	NOUN
admet-292	1370	6	.	.	PUNCT
admet-292	1371	1	phys.-chem	phys.-chem	PROPN
admet-292	1371	2	.	.	PUNCT
admet-292	1372	1	meth	meth	NOUN
admet-292	1372	2	.	.	PUNCT
admet-292	1373	1	drug	drug	NOUN
admet-292	1373	2	disc	disc	NOUN
admet-292	1373	3	.	.	PUNCT
admet-292	1374	1	dev	dev	PROPN
admet-292	1374	2	.	.	PROPN
admet-292	1374	3	,	,	PUNCT
admet-292	1374	4	red	red	PROPN
admet-292	1374	5	island	island	NOUN
admet-292	1374	6	,	,	PUNCT
admet-292	1374	7	croatia	croatia	PROPN
admet-292	1374	8	,	,	PUNCT
admet-292	1374	9	21	21	NUM
admet-292	1374	10	-	-	SYM
admet-292	1374	11	24	24	NUM
admet-292	1374	12	sep	sep	PROPN
admet-292	1374	13	2015	2015	NUM
admet-292	1374	14	.	.	PUNCT
admet-292	1375	1	[	[	X
admet-292	1375	2	151	151	NUM
admet-292	1375	3	]	]	PUNCT
admet-292	1375	4	s.	s.	PROPN
admet-292	1375	5	singh	singh	PROPN
admet-292	1375	6	,	,	PUNCT
admet-292	1375	7	t.	t.	PROPN
admet-292	1375	8	parikh	parikh	PROPN
admet-292	1375	9	,	,	PUNCT
admet-292	1375	10	h.k	h.k	PROPN
admet-292	1375	11	.	.	PROPN
admet-292	1375	12	sandhu	sandhu	PROPN
admet-292	1375	13	,	,	PUNCT
admet-292	1375	14	n.h	n.h	PROPN
admet-292	1375	15	.	.	PROPN
admet-292	1375	16	shah	shah	PROPN
admet-292	1375	17	,	,	PUNCT
admet-292	1375	18	a.w	a.w	PROPN
admet-292	1375	19	.	.	PROPN
admet-292	1375	20	malick	malick	PROPN
admet-292	1375	21	,	,	PUNCT
admet-292	1375	22	d.	d.	PROPN
admet-292	1375	23	singhal	singhal	PROPN
admet-292	1375	24	,	,	PUNCT
admet-292	1375	25	a.t.m	a.t.m	PROPN
admet-292	1375	26	.	.	PUNCT
admet-292	1376	1	serajuddin	serajuddin	PROPN
admet-292	1376	2	.	.	PUNCT
admet-292	1377	1	pharm	pharm	PROPN
admet-292	1377	2	.	.	PUNCT
admet-292	1378	1	res	re	NOUN
admet-292	1378	2	.	.	PROPN
admet-292	1379	1	30	30	NUM
admet-292	1379	2	(	(	PUNCT
admet-292	1379	3	2013	2013	NUM
admet-292	1379	4	)	)	PUNCT
admet-292	1379	5	1561	1561	NUM
admet-292	1379	6	-	-	SYM
admet-292	1379	7	1573	1573	NUM
admet-292	1379	8	.	.	PUNCT
admet-292	1380	1	[	[	X
admet-292	1380	2	152	152	NUM
admet-292	1380	3	]	]	X
admet-292	1380	4	s.h	s.h	PROPN
admet-292	1380	5	.	.	NOUN
admet-292	1380	6	yalkowsky	yalkowsky	ADJ
admet-292	1380	7	,	,	PUNCT
admet-292	1380	8	y.	y.	PROPN
admet-292	1380	9	he	he	PRON
admet-292	1380	10	,	,	PUNCT
admet-292	1380	11	p.	p.	PROPN
admet-292	1380	12	jain	jain	PROPN
admet-292	1380	13	.	.	PUNCT
admet-292	1381	1	handbook	handbook	NOUN
admet-292	1381	2	of	of	ADP
admet-292	1381	3	aqueous	aqueous	ADJ
admet-292	1381	4	solubility	solubility	NOUN
admet-292	1381	5	data	datum	NOUN
admet-292	1381	6	,	,	PUNCT
admet-292	1381	7	second	second	ADJ
admet-292	1381	8	edition	edition	NOUN
admet-292	1381	9	.	.	PUNCT
admet-292	1382	1	crc	crc	PROPN
admet-292	1382	2	press	press	PROPN
admet-292	1382	3	,	,	PUNCT
admet-292	1382	4	boca	boca	PROPN
admet-292	1382	5	raton	raton	PROPN
admet-292	1382	6	,	,	PUNCT
admet-292	1382	7	fl	fl	PROPN
admet-292	1382	8	,	,	PUNCT
admet-292	1382	9	2010	2010	NUM
admet-292	1382	10	.	.	PUNCT
admet-292	1383	1	[	[	X
admet-292	1383	2	153	153	NUM
admet-292	1383	3	]	]	X
admet-292	1383	4	h.t.s	h.t.s	NOUN
admet-292	1383	5	.	.	PUNCT
admet-292	1384	1	britton	britton	PROPN
admet-292	1384	2	,	,	PUNCT
admet-292	1384	3	r.a	r.a	PROPN
admet-292	1384	4	.	.	PROPN
admet-292	1384	5	robinson	robinson	PROPN
admet-292	1384	6	.	.	PUNCT
admet-292	1385	1	j.	j.	PROPN
admet-292	1385	2	chem	chem	PROPN
admet-292	1385	3	.	.	PUNCT
admet-292	1386	1	soc	soc	PROPN
admet-292	1386	2	.	.	PUNCT
admet-292	1387	1	(	(	PUNCT
admet-292	1387	2	1931	1931	NUM
admet-292	1387	3	)	)	PUNCT
admet-292	1387	4	1456	1456	NUM
admet-292	1387	5	-	-	SYM
admet-292	1387	6	1462	1462	NUM
admet-292	1387	7	.	.	PUNCT
admet-292	1388	1	[	[	X
admet-292	1388	2	154	154	NUM
admet-292	1388	3	]	]	PUNCT
admet-292	1388	4	j.	j.	PROPN
admet-292	1388	5	bjerrum	bjerrum	PROPN
admet-292	1388	6	.	.	PUNCT
admet-292	1389	1	metal	metal	NOUN
admet-292	1389	2	-	-	PUNCT
admet-292	1389	3	ammine	ammine	NOUN
admet-292	1389	4	formation	formation	NOUN
admet-292	1389	5	in	in	ADP
admet-292	1389	6	aqueous	aqueous	ADJ
admet-292	1389	7	solution	solution	NOUN
admet-292	1389	8	,	,	PUNCT
admet-292	1389	9	haase	haase	NOUN
admet-292	1389	10	,	,	PUNCT
admet-292	1389	11	copenhagen	copenhagen	PROPN
admet-292	1389	12	,	,	PUNCT
admet-292	1389	13	1941	1941	NUM
admet-292	1389	14	.	.	PUNCT
admet-292	1390	1	[	[	X
admet-292	1390	2	155	155	NUM
admet-292	1390	3	]	]	X
admet-292	1390	4	d.d	d.d	PROPN
admet-292	1390	5	.	.	PROPN
admet-292	1390	6	perrin	perrin	PROPN
admet-292	1390	7	,	,	PUNCT
admet-292	1390	8	b.	b.	PROPN
admet-292	1390	9	dempsey	dempsey	PROPN
admet-292	1390	10	.	.	PUNCT
admet-292	1391	1	buffers	buffer	NOUN
admet-292	1391	2	for	for	ADP
admet-292	1391	3	ph	ph	ADJ
admet-292	1391	4	and	and	CCONJ
admet-292	1391	5	metal	metal	NOUN
admet-292	1391	6	ion	ion	NOUN
admet-292	1391	7	control	control	NOUN
admet-292	1391	8	,	,	PUNCT
admet-292	1391	9	chapman	chapman	NOUN
admet-292	1391	10	and	and	CCONJ
admet-292	1391	11	hall	hall	PROPN
admet-292	1391	12	,	,	PUNCT
admet-292	1391	13	london	london	PROPN
admet-292	1391	14	,	,	PUNCT
admet-292	1391	15	1974	1974	NUM
admet-292	1391	16	.	.	PUNCT
admet-292	1392	1	[	[	X
admet-292	1392	2	156	156	NUM
admet-292	1392	3	]	]	PUNCT
admet-292	1392	4	united	united	PROPN
admet-292	1392	5	states	states	PROPN
admet-292	1392	6	pharmacopeia	pharmacopeia	PROPN
admet-292	1392	7	-	-	PUNCT
admet-292	1392	8	national	national	ADJ
admet-292	1392	9	formulary	formulary	NOUN
admet-292	1392	10	(	(	PUNCT
admet-292	1392	11	usp25	usp25	PROPN
admet-292	1392	12	nf20	nf20	PROPN
admet-292	1392	13	)	)	PUNCT
admet-292	1392	14	,	,	PUNCT
admet-292	1392	15	2002	2002	NUM
admet-292	1392	16	.	.	PUNCT
admet-292	1393	1	[	[	X
admet-292	1393	2	157	157	NUM
admet-292	1393	3	]	]	X
admet-292	1393	4	t.c	t.c	PROPN
admet-292	1393	5	.	.	PROPN
admet-292	1393	6	mcilvaine	mcilvaine	PROPN
admet-292	1393	7	.	.	PUNCT
admet-292	1394	1	j.	j.	PROPN
admet-292	1394	2	biol	biol	PROPN
admet-292	1394	3	.	.	PUNCT
admet-292	1395	1	chem	chem	PROPN
admet-292	1395	2	.	.	PUNCT
admet-292	1396	1	49	49	NUM
admet-292	1396	2	(	(	PUNCT
admet-292	1396	3	1921	1921	NUM
admet-292	1396	4	)	)	PUNCT
admet-292	1396	5	183	183	NUM
admet-292	1396	6	-	-	SYM
admet-292	1396	7	186	186	NUM
admet-292	1396	8	.	.	PUNCT
admet-292	1397	1	[	[	X
admet-292	1397	2	158	158	NUM
admet-292	1397	3	]	]	X
admet-292	1397	4	f.h	f.h	PROPN
admet-292	1397	5	.	.	PROPN
admet-292	1397	6	sweeton	sweeton	PROPN
admet-292	1397	7	,	,	PUNCT
admet-292	1397	8	r.e	r.e	PROPN
admet-292	1397	9	.	.	PROPN
admet-292	1397	10	mesmer	mesmer	PROPN
admet-292	1397	11	,	,	PUNCT
admet-292	1397	12	c.f	c.f	PROPN
admet-292	1397	13	.	.	PROPN
admet-292	1397	14	baes	baes	PROPN
admet-292	1397	15	,	,	PUNCT
admet-292	1397	16	jr	jr	PROPN
admet-292	1397	17	.	.	PUNCT
admet-292	1397	18	j.	j.	PROPN
admet-292	1397	19	solut	solut	PROPN
admet-292	1397	20	.	.	PUNCT
admet-292	1398	1	chem	chem	NOUN
admet-292	1398	2	.	.	PUNCT
admet-292	1399	1	3	3	NUM
admet-292	1399	2	(	(	PUNCT
admet-292	1399	3	1974	1974	NUM
admet-292	1399	4	)	)	PUNCT
admet-292	1399	5	191	191	NUM
admet-292	1399	6	-	-	SYM
admet-292	1399	7	214	214	NUM
admet-292	1399	8	.	.	PUNCT
admet-292	1400	1	[	[	X
admet-292	1400	2	159	159	NUM
admet-292	1400	3	]	]	PUNCT
admet-292	1400	4	a.	a.	NOUN
admet-292	1400	5	avdeef	avdeef	PROPN
admet-292	1400	6	.	.	PUNCT
admet-292	1401	1	anal	anal	PROPN
admet-292	1401	2	.	.	PUNCT
admet-292	1402	1	chim	chim	PROPN
admet-292	1402	2	.	.	PUNCT
admet-292	1403	1	acta	acta	PROPN
admet-292	1403	2	148	148	NUM
admet-292	1403	3	(	(	PUNCT
admet-292	1403	4	1983	1983	NUM
admet-292	1403	5	)	)	PUNCT
admet-292	1403	6	237	237	NUM
admet-292	1403	7	-	-	SYM
admet-292	1403	8	244	244	NUM
admet-292	1403	9	.	.	PUNCT
admet-292	1404	1	alex	alex	PROPN
admet-292	1404	2	avdeef	avdeef	PROPN
admet-292	1404	3	et	et	PROPN
admet-292	1404	4	al	al	PROPN
admet-292	1404	5	.	.	PROPN
admet-292	1404	6	admet	admet	PROPN
admet-292	1404	7	&	&	CCONJ
admet-292	1404	8	dmpk	dmpk	PROPN
admet-292	1404	9	4(2	4(2	NUM
admet-292	1404	10	)	)	PUNCT
admet-292	1404	11	(	(	PUNCT
admet-292	1404	12	2016	2016	NUM
admet-292	1404	13	)	)	PUNCT
admet-292	1404	14	117	117	NUM
admet-292	1404	15	-	-	SYM
admet-292	1404	16	178	178	NUM
admet-292	1404	17	162	162	NUM
admet-292	1404	18	appendix	appendix	NOUN
admet-292	1404	19	a	a	DET
admet-292	1404	20	–	–	PUNCT
admet-292	1404	21	buffer	buffer	NOUN
admet-292	1404	22	capacity	capacity	NOUN
admet-292	1404	23	and	and	CCONJ
admet-292	1404	24	ionic	ionic	ADJ
admet-292	1404	25	strength	strength	NOUN
admet-292	1404	26	–	–	PUNCT
admet-292	1404	27	too	too	ADV
admet-292	1404	28	little	little	ADJ
admet-292	1404	29	,	,	PUNCT
admet-292	1404	30	too	too	ADV
admet-292	1404	31	much	much	ADJ
admet-292	1404	32	,	,	PUNCT
admet-292	1404	33	or	or	CCONJ
admet-292	1404	34	just	just	ADV
admet-292	1404	35	about	about	ADV
admet-292	1404	36	right	right	ADV
admet-292	1404	37	many	many	ADJ
admet-292	1404	38	buffer	buffer	NOUN
admet-292	1404	39	formulations	formulation	NOUN
admet-292	1404	40	have	have	AUX
admet-292	1404	41	been	be	AUX
admet-292	1404	42	described	describe	VERB
admet-292	1404	43	in	in	ADP
admet-292	1404	44	the	the	DET
admet-292	1404	45	literature	literature	NOUN
admet-292	1404	46	.	.	PUNCT
admet-292	1405	1	very	very	ADV
admet-292	1405	2	useful	useful	ADJ
admet-292	1405	3	detailed	detailed	ADJ
admet-292	1405	4	descriptions	description	NOUN
admet-292	1405	5	of	of	ADP
admet-292	1405	6	specialty	specialty	NOUN
admet-292	1405	7	buffers	buffer	NOUN
admet-292	1405	8	have	have	AUX
admet-292	1405	9	been	be	AUX
admet-292	1405	10	tabulated	tabulate	VERB
admet-292	1405	11	by	by	ADP
admet-292	1405	12	perrin	perrin	NOUN
admet-292	1405	13	and	and	CCONJ
admet-292	1405	14	dempsey	dempsey	PROPN
admet-292	1406	1	[	[	X
admet-292	1406	2	155	155	NUM
admet-292	1406	3	]	]	PUNCT
admet-292	1406	4	.	.	PUNCT
admet-292	1407	1	in	in	ADP
admet-292	1407	2	this	this	DET
admet-292	1407	3	appendix	appendix	NOUN
admet-292	1407	4	,	,	PUNCT
admet-292	1407	5	five	five	NUM
admet-292	1407	6	examples	example	NOUN
admet-292	1407	7	of	of	ADP
admet-292	1407	8	buffer	buffer	NOUN
admet-292	1407	9	solutions	solution	NOUN
admet-292	1407	10	are	be	AUX
admet-292	1407	11	described	describe	VERB
admet-292	1407	12	,	,	PUNCT
admet-292	1407	13	with	with	ADP
admet-292	1407	14	emphasis	emphasis	NOUN
admet-292	1407	15	on	on	ADP
admet-292	1407	16	use	use	NOUN
admet-292	1407	17	in	in	ADP
admet-292	1407	18	solubility	solubility	NOUN
admet-292	1407	19	measurements	measurement	NOUN
admet-292	1407	20	.	.	PUNCT
admet-292	1408	1	unbuffered	unbuffered	ADJ
admet-292	1408	2	water	water	NOUN
admet-292	1408	3	figure	figure	NOUN
admet-292	1408	4	a1a	a1a	PROPN
admet-292	1408	5	shows	show	VERB
admet-292	1408	6	the	the	DET
admet-292	1408	7	buffer	buffer	NOUN
admet-292	1408	8	capacity	capacity	NOUN
admet-292	1408	9	and	and	CCONJ
admet-292	1408	10	ionic	ionic	ADJ
admet-292	1408	11	strength	strength	NOUN
admet-292	1408	12	distribution	distribution	NOUN
admet-292	1408	13	as	as	ADP
admet-292	1408	14	a	a	DET
admet-292	1408	15	function	function	NOUN
admet-292	1408	16	of	of	ADP
admet-292	1408	17	ph	ph	NOUN
admet-292	1408	18	for	for	ADP
admet-292	1408	19	the	the	DET
admet-292	1408	20	“	"	PUNCT
admet-292	1408	21	blank	blank	ADJ
admet-292	1408	22	”	"	PUNCT
admet-292	1408	23	titration	titration	NOUN
admet-292	1408	24	shown	show	VERB
admet-292	1408	25	in	in	ADP
admet-292	1408	26	figure	figure	NOUN
admet-292	1408	27	a2a	a2a	PROPN
admet-292	1408	28	.	.	PUNCT
admet-292	1409	1	figure	figure	NOUN
admet-292	1409	2	a1	a1	PROPN
admet-292	1409	3	.	.	PUNCT
admet-292	1409	4	plots	plot	NOUN
admet-292	1409	5	of	of	ADP
admet-292	1409	6	the	the	DET
admet-292	1409	7	buffer	buffer	NOUN
admet-292	1409	8	capacity	capacity	NOUN
admet-292	1409	9	and	and	CCONJ
admet-292	1409	10	ionic	ionic	ADJ
admet-292	1409	11	strength	strength	NOUN
admet-292	1409	12	as	as	ADP
admet-292	1409	13	a	a	DET
admet-292	1409	14	function	function	NOUN
admet-292	1409	15	of	of	ADP
admet-292	1409	16	ph	ph	NOUN
admet-292	1409	17	for	for	ADP
admet-292	1409	18	the	the	DET
admet-292	1409	19	unbuffered	unbuffered	ADJ
admet-292	1409	20	“	"	PUNCT
admet-292	1409	21	blank	blank	NOUN
admet-292	1409	22	”	"	PUNCT
admet-292	1409	23	(	(	PUNCT
admet-292	1409	24	a	a	DET
admet-292	1409	25	)	)	PUNCT
admet-292	1409	26	solution	solution	NOUN
admet-292	1409	27	,	,	PUNCT
admet-292	1409	28	for	for	ADP
admet-292	1409	29	the	the	DET
admet-292	1409	30	common	common	ADJ
admet-292	1409	31	phosphate	phosphate	NOUN
admet-292	1409	32	buffer	buffer	NOUN
admet-292	1409	33	(	(	PUNCT
admet-292	1409	34	b	b	NOUN
admet-292	1409	35	)	)	PUNCT
admet-292	1409	36	,	,	PUNCT
admet-292	1409	37	and	and	CCONJ
admet-292	1409	38	for	for	ADP
admet-292	1409	39	four	four	NUM
admet-292	1409	40	“	"	PUNCT
admet-292	1409	41	universal	universal	ADJ
admet-292	1409	42	”	"	PUNCT
admet-292	1409	43	buffer	buffer	NOUN
admet-292	1409	44	solutions	solution	NOUN
admet-292	1409	45	(	(	PUNCT
admet-292	1409	46	c	c	NOUN
admet-292	1409	47	-	-	SYM
admet-292	1409	48	f	f	NOUN
admet-292	1409	49	)	)	PUNCT
admet-292	1409	50	.	.	PUNCT
admet-292	1410	1	this	this	PRON
admet-292	1410	2	is	be	AUX
admet-292	1410	3	a	a	DET
admet-292	1410	4	case	case	NOUN
admet-292	1410	5	of	of	ADP
admet-292	1410	6	the	the	DET
admet-292	1410	7	least	least	ADJ
admet-292	1410	8	buffered	buffer	VERB
admet-292	1410	9	aqueous	aqueous	ADJ
admet-292	1410	10	solution	solution	NOUN
admet-292	1410	11	possible	possible	ADJ
admet-292	1410	12	,	,	PUNCT
admet-292	1410	13	where	where	SCONJ
admet-292	1410	14	trace	trace	NOUN
admet-292	1410	15	level	level	NOUN
admet-292	1410	16	of	of	ADP
admet-292	1410	17	buffering	buffering	NOUN
admet-292	1410	18	is	be	AUX
admet-292	1410	19	solely	solely	ADV
admet-292	1410	20	admet	admet	ADJ
admet-292	1410	21	&	&	CCONJ
admet-292	1410	22	dmpk	dmpk	PROPN
admet-292	1410	23	4(2	4(2	NUM
admet-292	1410	24	)	)	PUNCT
admet-292	1410	25	(	(	PUNCT
admet-292	1410	26	2016	2016	NUM
admet-292	1410	27	)	)	PUNCT
admet-292	1410	28	117	117	NUM
admet-292	1410	29	-	-	SYM
admet-292	1410	30	178	178	NUM
admet-292	1410	31	consensus	consensus	NOUN
admet-292	1410	32	recommendations	recommendation	NOUN
admet-292	1410	33	for	for	ADP
admet-292	1410	34	improving	improve	VERB
admet-292	1410	35	solubility	solubility	NOUN
admet-292	1410	36	-	-	PUNCT
admet-292	1410	37	ph	ph	ADJ
admet-292	1410	38	data	datum	NOUN
admet-292	1410	39	quality	quality	NOUN
admet-292	1410	40	doi	doi	NOUN
admet-292	1410	41	:	:	PUNCT
admet-292	1410	42	10.5599	10.5599	NUM
admet-292	1410	43	/	/	SYM
admet-292	1410	44	admet.4.2.292	admet.4.2.292	DET
admet-292	1410	45	163	163	NUM
admet-292	1410	46	provided	provide	VERB
admet-292	1410	47	by	by	ADP
admet-292	1410	48	the	the	DET
admet-292	1410	49	ionization	ionization	NOUN
admet-292	1410	50	of	of	ADP
admet-292	1410	51	pure	pure	ADJ
admet-292	1410	52	water	water	NOUN
admet-292	1410	53	.	.	PUNCT
admet-292	1411	1	the	the	DET
admet-292	1411	2	region	region	NOUN
admet-292	1411	3	between	between	ADP
admet-292	1411	4	ph	ph	PROPN
admet-292	1411	5	4	4	NUM
admet-292	1411	6	and	and	CCONJ
admet-292	1411	7	10	10	NUM
admet-292	1411	8	is	be	AUX
admet-292	1411	9	characterized	characterize	VERB
admet-292	1411	10	by	by	ADP
admet-292	1411	11	buffer	buffer	NOUN
admet-292	1411	12	capacity	capacity	NOUN
admet-292	1411	13	<	<	X
admet-292	1411	14	0.005	0.005	NUM
admet-292	1411	15	mm	mm	NOUN
admet-292	1411	16	/	/	SYM
admet-292	1411	17	ph	ph	ADJ
admet-292	1411	18	and	and	CCONJ
admet-292	1411	19	ionic	ionic	ADJ
admet-292	1411	20	strength	strength	NOUN
admet-292	1411	21	<	<	X
admet-292	1411	22	0.0005	0.0005	NUM
admet-292	1411	23	m.	m.	NOUN
admet-292	1411	24	the	the	DET
admet-292	1411	25	commercial	commercial	ADJ
admet-292	1411	26	pka	pka	PROPN
admet-292	1411	27	analyzer	analyzer	NOUN
admet-292	1411	28	dispensers	dispenser	NOUN
admet-292	1411	29	adding	add	VERB
admet-292	1411	30	minimum	minimum	ADJ
admet-292	1411	31	volumes	volume	NOUN
admet-292	1411	32	of	of	ADP
admet-292	1411	33	0.5	0.5	NUM
admet-292	1411	34	m	m	PROPN
admet-292	1411	35	hcl	hcl	PROPN
admet-292	1411	36	or	or	CCONJ
admet-292	1411	37	naoh	naoh	NOUN
admet-292	1411	38	would	would	AUX
admet-292	1411	39	not	not	PART
admet-292	1411	40	be	be	AUX
admet-292	1411	41	able	able	ADJ
admet-292	1411	42	to	to	PART
admet-292	1411	43	resolve	resolve	VERB
admet-292	1411	44	ph	ph	ADJ
admet-292	1411	45	points	point	NOUN
admet-292	1411	46	any	any	ADV
admet-292	1411	47	better	well	ADJ
admet-292	1411	48	than	than	ADP
admet-292	1411	49	about	about	ADV
admet-292	1411	50	2	2	NUM
admet-292	1411	51	ph	ph	NOUN
admet-292	1411	52	units	unit	NOUN
admet-292	1411	53	in	in	ADP
admet-292	1411	54	the	the	DET
admet-292	1411	55	vicinity	vicinity	NOUN
admet-292	1411	56	of	of	ADP
admet-292	1411	57	ph	ph	ADJ
admet-292	1411	58	7	7	NUM
admet-292	1411	59	.	.	PUNCT
admet-292	1412	1	this	this	DET
admet-292	1412	2	case	case	NOUN
admet-292	1412	3	may	may	AUX
admet-292	1412	4	be	be	AUX
admet-292	1412	5	simply	simply	ADV
admet-292	1412	6	called	call	VERB
admet-292	1412	7	the	the	DET
admet-292	1412	8	“	"	PUNCT
admet-292	1412	9	unbuffered	unbuffered	ADJ
admet-292	1412	10	”	"	PUNCT
admet-292	1412	11	solution	solution	NOUN
admet-292	1412	12	.	.	PUNCT
admet-292	1413	1	usp	usp	NOUN
admet-292	1413	2	50	50	NUM
admet-292	1413	3	mm	mm	NOUN
admet-292	1413	4	phosphate	phosphate	NOUN
admet-292	1413	5	buffer	buffer	NOUN
admet-292	1413	6	figure	figure	NOUN
admet-292	1413	7	a1b	a1b	PROPN
admet-292	1413	8	shows	show	VERB
admet-292	1413	9	the	the	DET
admet-292	1413	10	buffer	buffer	NOUN
admet-292	1413	11	capacity	capacity	NOUN
admet-292	1413	12	and	and	CCONJ
admet-292	1413	13	ionic	ionic	ADJ
admet-292	1413	14	strength	strength	NOUN
admet-292	1413	15	distribution	distribution	NOUN
admet-292	1413	16	as	as	ADP
admet-292	1413	17	a	a	DET
admet-292	1413	18	function	function	NOUN
admet-292	1413	19	of	of	ADP
admet-292	1413	20	ph	ph	NOUN
admet-292	1413	21	for	for	ADP
admet-292	1413	22	the	the	DET
admet-292	1413	23	extended	extended	ADJ
admet-292	1413	24	version	version	NOUN
admet-292	1413	25	of	of	ADP
admet-292	1413	26	the	the	DET
admet-292	1413	27	popular	popular	ADJ
admet-292	1413	28	50	50	NUM
admet-292	1413	29	mm	mm	NOUN
admet-292	1413	30	phosphate	phosphate	NOUN
admet-292	1413	31	buffer	buffer	NOUN
admet-292	1413	32	defined	define	VERB
admet-292	1413	33	in	in	ADP
admet-292	1413	34	u.s	u.s	PROPN
admet-292	1413	35	.	.	PROPN
admet-292	1413	36	pharmacopeia	pharmacopeia	PROPN
admet-292	1413	37	–	–	PUNCT
admet-292	1413	38	national	national	PROPN
admet-292	1413	39	formulary	formulary	NOUN
admet-292	1413	40	no	no	NOUN
admet-292	1413	41	.	.	NOUN
admet-292	1414	1	25	25	NUM
admet-292	1415	1	[	[	X
admet-292	1415	2	156	156	NUM
admet-292	1415	3	]	]	PUNCT
admet-292	1415	4	.	.	PUNCT
admet-292	1416	1	a	a	DET
admet-292	1416	2	characteristic	characteristic	ADJ
admet-292	1416	3	feature	feature	NOUN
admet-292	1416	4	is	be	AUX
admet-292	1416	5	the	the	DET
admet-292	1416	6	high	high	ADJ
admet-292	1416	7	buffering	buffering	NOUN
admet-292	1416	8	occurring	occur	VERB
admet-292	1416	9	near	near	ADP
admet-292	1416	10	ph	ph	PROPN
admet-292	1416	11	6.8	6.8	NUM
admet-292	1416	12	(	(	PUNCT
admet-292	1416	13	27.4	27.4	NUM
admet-292	1416	14	mm	mm	NOUN
admet-292	1416	15	/	/	SYM
admet-292	1416	16	ph	ph	PROPN
admet-292	1416	17	)	)	PUNCT
admet-292	1416	18	,	,	PUNCT
admet-292	1416	19	as	as	SCONJ
admet-292	1416	20	shown	show	VERB
admet-292	1416	21	in	in	ADP
admet-292	1416	22	the	the	DET
admet-292	1416	23	figure	figure	NOUN
admet-292	1416	24	.	.	PUNCT
admet-292	1417	1	buffer	buffer	NOUN
admet-292	1417	2	capacity	capacity	NOUN
admet-292	1417	3	becomes	become	VERB
admet-292	1417	4	minimal	minimal	ADJ
admet-292	1417	5	around	around	ADP
admet-292	1417	6	ph	ph	PROPN
admet-292	1417	7	4.4	4.4	NUM
admet-292	1417	8	(	(	PUNCT
admet-292	1417	9	1.0	1.0	NUM
admet-292	1417	10	mm	mm	NOUN
admet-292	1417	11	/	/	SYM
admet-292	1417	12	ph	ph	NOUN
admet-292	1417	13	)	)	PUNCT
admet-292	1417	14	and	and	CCONJ
admet-292	1417	15	9.3	9.3	NUM
admet-292	1417	16	(	(	PUNCT
admet-292	1417	17	0.7	0.7	NUM
admet-292	1417	18	mm	mm	NOUN
admet-292	1417	19	/	/	SYM
admet-292	1417	20	ph	ph	PROPN
admet-292	1417	21	)	)	PUNCT
admet-292	1417	22	.	.	PUNCT
admet-292	1418	1	this	this	PRON
admet-292	1418	2	is	be	AUX
admet-292	1418	3	just	just	ADV
admet-292	1418	4	about	about	ADV
admet-292	1418	5	enough	enough	ADJ
admet-292	1418	6	capacity	capacity	NOUN
admet-292	1418	7	for	for	ADP
admet-292	1418	8	commercial	commercial	ADJ
admet-292	1418	9	pka	pka	PROPN
admet-292	1418	10	analyzers	analyzer	NOUN
admet-292	1418	11	to	to	PART
admet-292	1418	12	adjust	adjust	VERB
admet-292	1418	13	the	the	DET
admet-292	1418	14	ph	ph	NOUN
admet-292	1418	15	of	of	ADP
admet-292	1418	16	the	the	DET
admet-292	1418	17	phosphate	phosphate	ADJ
admet-292	1418	18	solutions	solution	NOUN
admet-292	1418	19	using	use	VERB
admet-292	1418	20	typical	typical	ADJ
admet-292	1418	21	titrants	titrant	NOUN
admet-292	1418	22	.	.	PUNCT
admet-292	1419	1	although	although	SCONJ
admet-292	1419	2	the	the	DET
admet-292	1419	3	average	average	ADJ
admet-292	1419	4	ionic	ionic	ADJ
admet-292	1419	5	strength	strength	NOUN
admet-292	1419	6	is	be	AUX
admet-292	1419	7	near	near	ADP
admet-292	1419	8	0.1	0.1	NUM
admet-292	1419	9	m	m	NOUN
admet-292	1419	10	,	,	PUNCT
admet-292	1419	11	the	the	DET
admet-292	1419	12	value	value	NOUN
admet-292	1419	13	increases	increase	VERB
admet-292	1419	14	from	from	ADP
admet-292	1419	15	0.05	0.05	NUM
admet-292	1419	16	m	m	NOUN
admet-292	1419	17	to	to	ADP
admet-292	1419	18	0.14	0.14	NUM
admet-292	1419	19	m	m	NOUN
admet-292	1419	20	as	as	SCONJ
admet-292	1419	21	ph	ph	NOUN
admet-292	1419	22	is	be	AUX
admet-292	1419	23	adjusted	adjust	VERB
admet-292	1419	24	across	across	ADP
admet-292	1419	25	the	the	DET
admet-292	1419	26	ph	ph	ADJ
admet-292	1419	27	6.8	6.8	NUM
admet-292	1419	28	region	region	NOUN
admet-292	1419	29	,	,	PUNCT
admet-292	1419	30	as	as	SCONJ
admet-292	1419	31	indicated	indicate	VERB
admet-292	1419	32	in	in	ADP
admet-292	1419	33	figure	figure	NOUN
admet-292	1419	34	a1b	a1b	PROPN
admet-292	1419	35	.	.	PUNCT
admet-292	1420	1	compensation	compensation	NOUN
admet-292	1420	2	for	for	ADP
admet-292	1420	3	this	this	DET
admet-292	1420	4	level	level	NOUN
admet-292	1420	5	of	of	ADP
admet-292	1420	6	change	change	NOUN
admet-292	1420	7	in	in	ADP
admet-292	1420	8	ionic	ionic	ADJ
admet-292	1420	9	strength	strength	NOUN
admet-292	1420	10	is	be	AUX
admet-292	1420	11	theoretically	theoretically	ADV
admet-292	1420	12	feasible	feasible	ADJ
admet-292	1420	13	[	[	PUNCT
admet-292	1420	14	22	22	NUM
admet-292	1420	15	]	]	PUNCT
admet-292	1420	16	.	.	PUNCT
admet-292	1421	1	the	the	DET
admet-292	1421	2	phosphate	phosphate	ADJ
admet-292	1421	3	buffer	buffer	NOUN
admet-292	1421	4	is	be	AUX
admet-292	1421	5	suitable	suitable	ADJ
admet-292	1421	6	for	for	ADP
admet-292	1421	7	most	most	ADJ
admet-292	1421	8	applications	application	NOUN
admet-292	1421	9	in	in	ADP
admet-292	1421	10	solubility	solubility	NOUN
admet-292	1421	11	measurement	measurement	NOUN
admet-292	1421	12	.	.	PUNCT
admet-292	1422	1	but	but	CCONJ
admet-292	1422	2	one	one	PRON
admet-292	1422	3	could	could	AUX
admet-292	1422	4	do	do	VERB
admet-292	1422	5	better	well	ADV
admet-292	1422	6	.	.	PUNCT
admet-292	1423	1	mcilvaine	mcilvaine	ADJ
admet-292	1423	2	universal	universal	ADJ
admet-292	1423	3	buffer	buffer	NOUN
admet-292	1423	4	the	the	DET
admet-292	1423	5	mcilvaine	mcilvaine	ADJ
admet-292	1423	6	universal	universal	ADJ
admet-292	1423	7	buffer	buffer	NOUN
admet-292	1424	1	[	[	X
admet-292	1424	2	157	157	NUM
admet-292	1424	3	]	]	PUNCT
admet-292	1424	4	is	be	AUX
admet-292	1424	5	sometimes	sometimes	ADV
admet-292	1424	6	used	use	VERB
admet-292	1424	7	in	in	ADP
admet-292	1424	8	dissolution	dissolution	NOUN
admet-292	1424	9	studies	study	NOUN
admet-292	1424	10	as	as	ADP
admet-292	1424	11	a	a	DET
admet-292	1424	12	function	function	NOUN
admet-292	1424	13	of	of	ADP
admet-292	1424	14	ph	ph	PROPN
admet-292	1424	15	.	.	PUNCT
admet-292	1425	1	it	it	PRON
admet-292	1425	2	is	be	AUX
admet-292	1425	3	formulated	formulate	VERB
admet-292	1425	4	by	by	ADP
admet-292	1425	5	adding	add	VERB
admet-292	1425	6	different	different	ADJ
admet-292	1425	7	mixtures	mixture	NOUN
admet-292	1425	8	of	of	ADP
admet-292	1425	9	100	100	NUM
admet-292	1425	10	mm	mm	NOUN
admet-292	1425	11	citric	citric	ADJ
admet-292	1425	12	acid	acid	NOUN
admet-292	1425	13	(	(	PUNCT
admet-292	1425	14	3	3	NUM
admet-292	1425	15	-	-	SYM
admet-292	1425	16	98	98	NUM
admet-292	1425	17	mm	mm	NOUN
admet-292	1425	18	)	)	PUNCT
admet-292	1425	19	and	and	CCONJ
admet-292	1425	20	200	200	NUM
admet-292	1425	21	mm	mm	PROPN
admet-292	1425	22	na2hpo4	na2hpo4	PROPN
admet-292	1425	23	(	(	PUNCT
admet-292	1425	24	4	4	NUM
admet-292	1425	25	-	-	SYM
admet-292	1425	26	195	195	NUM
admet-292	1425	27	mm	mm	NOUN
admet-292	1425	28	)	)	PUNCT
admet-292	1425	29	,	,	PUNCT
admet-292	1425	30	to	to	PART
admet-292	1425	31	cover	cover	VERB
admet-292	1425	32	the	the	DET
admet-292	1425	33	ph	ph	ADJ
admet-292	1425	34	range	range	NOUN
admet-292	1425	35	from	from	ADP
admet-292	1425	36	2	2	NUM
admet-292	1425	37	to	to	ADP
admet-292	1425	38	8	8	NUM
admet-292	1425	39	.	.	PUNCT
admet-292	1426	1	the	the	DET
admet-292	1426	2	buffer	buffer	NOUN
admet-292	1426	3	mixture	mixture	NOUN
admet-292	1426	4	has	have	VERB
admet-292	1426	5	high	high	ADJ
admet-292	1426	6	buffer	buffer	NOUN
admet-292	1426	7	capacity	capacity	NOUN
admet-292	1426	8	,	,	PUNCT
admet-292	1426	9	to	to	PART
admet-292	1426	10	be	be	AUX
admet-292	1426	11	sure	sure	ADJ
admet-292	1426	12	.	.	PUNCT
admet-292	1427	1	its	its	PRON
admet-292	1427	2	unfavorable	unfavorable	ADJ
admet-292	1427	3	property	property	NOUN
admet-292	1427	4	vis	vis	X
admet-292	1427	5	-	-	X
admet-292	1427	6	à	à	X
admet-292	1427	7	-	-	PUNCT
admet-292	1427	8	vis	vis	X
admet-292	1427	9	solubility	solubility	NOUN
admet-292	1427	10	measurement	measurement	NOUN
admet-292	1427	11	is	be	AUX
admet-292	1427	12	that	that	SCONJ
admet-292	1427	13	ionic	ionic	ADJ
admet-292	1427	14	strength	strength	NOUN
admet-292	1427	15	varies	vary	VERB
admet-292	1427	16	from	from	ADP
admet-292	1427	17	near	near	ADP
admet-292	1427	18	zero	zero	NUM
admet-292	1427	19	to	to	ADP
admet-292	1427	20	0.5	0.5	NUM
admet-292	1427	21	m	m	NOUN
admet-292	1427	22	,	,	PUNCT
admet-292	1427	23	as	as	SCONJ
admet-292	1427	24	can	can	AUX
admet-292	1427	25	be	be	AUX
admet-292	1427	26	seen	see	VERB
admet-292	1427	27	in	in	ADP
admet-292	1427	28	figure	figure	NOUN
admet-292	1427	29	a1c	a1c	PROPN
admet-292	1427	30	.	.	PUNCT
admet-292	1428	1	also	also	ADV
admet-292	1428	2	,	,	PUNCT
admet-292	1428	3	the	the	DET
admet-292	1428	4	very	very	ADV
admet-292	1428	5	high	high	ADJ
admet-292	1428	6	and	and	CCONJ
admet-292	1428	7	continuously	continuously	ADV
admet-292	1428	8	-	-	PUNCT
admet-292	1428	9	variable	variable	ADJ
admet-292	1428	10	phosphate	phosphate	NOUN
admet-292	1428	11	concentration	concentration	NOUN
admet-292	1428	12	does	do	AUX
admet-292	1428	13	not	not	PART
admet-292	1428	14	make	make	VERB
admet-292	1428	15	this	this	PRON
admet-292	1428	16	a	a	DET
admet-292	1428	17	suitable	suitable	ADJ
admet-292	1428	18	buffer	buffer	NOUN
admet-292	1428	19	for	for	ADP
admet-292	1428	20	studying	study	VERB
admet-292	1428	21	sparingly	sparingly	ADV
admet-292	1428	22	-	-	PUNCT
admet-292	1428	23	soluble	soluble	ADJ
admet-292	1428	24	basic	basic	ADJ
admet-292	1428	25	drugs	drug	NOUN
admet-292	1428	26	,	,	PUNCT
admet-292	1428	27	since	since	SCONJ
admet-292	1428	28	analysis	analysis	NOUN
admet-292	1428	29	of	of	ADP
admet-292	1428	30	drug	drug	NOUN
admet-292	1428	31	-	-	PUNCT
admet-292	1428	32	phosphate	phosphate	NOUN
admet-292	1428	33	salt	salt	NOUN
admet-292	1428	34	precipitates	precipitate	NOUN
admet-292	1428	35	could	could	AUX
admet-292	1428	36	be	be	AUX
admet-292	1428	37	unwieldy	unwieldy	ADJ
admet-292	1428	38	[	[	X
admet-292	1428	39	24	24	NUM
admet-292	1428	40	]	]	PUNCT
admet-292	1428	41	.	.	PUNCT
admet-292	1429	1	in	in	ADP
admet-292	1429	2	some	some	DET
admet-292	1429	3	cases	case	NOUN
admet-292	1429	4	the	the	DET
admet-292	1429	5	mcilvaine	mcilvaine	ADJ
admet-292	1429	6	buffer	buffer	NOUN
admet-292	1429	7	could	could	AUX
admet-292	1429	8	be	be	AUX
admet-292	1429	9	useful	useful	ADJ
admet-292	1429	10	for	for	ADP
admet-292	1429	11	studying	study	VERB
admet-292	1429	12	acidic	acidic	ADJ
admet-292	1429	13	drugs	drug	NOUN
admet-292	1429	14	.	.	PUNCT
admet-292	1430	1	but	but	CCONJ
admet-292	1430	2	there	there	PRON
admet-292	1430	3	are	be	VERB
admet-292	1430	4	better	well	ADJ
admet-292	1430	5	choices	choice	NOUN
admet-292	1430	6	.	.	PUNCT
admet-292	1431	1	britton	britton	PROPN
admet-292	1431	2	-	-	PUNCT
admet-292	1431	3	robinson	robinson	PROPN
admet-292	1431	4	universal	universal	ADJ
admet-292	1431	5	buffer	buffer	NOUN
admet-292	1431	6	a	a	DET
admet-292	1431	7	very	very	ADV
admet-292	1431	8	well	well	ADV
admet-292	1431	9	formulated	formulated	ADJ
admet-292	1431	10	universal	universal	ADJ
admet-292	1431	11	buffer	buffer	NOUN
admet-292	1431	12	is	be	AUX
admet-292	1431	13	that	that	PRON
admet-292	1431	14	of	of	ADP
admet-292	1431	15	britton	britton	PROPN
admet-292	1431	16	-	-	PUNCT
admet-292	1431	17	robinson	robinson	PROPN
admet-292	1432	1	[	[	X
admet-292	1432	2	153	153	NUM
admet-292	1432	3	]	]	PUNCT
admet-292	1432	4	.	.	PUNCT
admet-292	1433	1	it	it	PRON
admet-292	1433	2	consists	consist	VERB
admet-292	1433	3	of	of	ADP
admet-292	1433	4	equimolar	equimolar	NOUN
admet-292	1433	5	(	(	PUNCT
admet-292	1433	6	e.g.	e.g.	ADV
admet-292	1433	7	,	,	PUNCT
admet-292	1433	8	40	40	NUM
admet-292	1433	9	mm	mm	NOUN
admet-292	1433	10	)	)	PUNCT
admet-292	1433	11	mixtures	mixture	NOUN
admet-292	1433	12	of	of	ADP
admet-292	1433	13	acetic	acetic	ADJ
admet-292	1433	14	acid	acid	NOUN
admet-292	1433	15	,	,	PUNCT
admet-292	1433	16	phosphoric	phosphoric	ADJ
admet-292	1433	17	acid	acid	NOUN
admet-292	1433	18	,	,	PUNCT
admet-292	1433	19	and	and	CCONJ
admet-292	1433	20	boric	boric	ADJ
admet-292	1433	21	acid	acid	NOUN
admet-292	1434	1	[	[	X
admet-292	1434	2	22	22	NUM
admet-292	1434	3	,	,	PUNCT
admet-292	1434	4	45	45	NUM
admet-292	1434	5	]	]	PUNCT
admet-292	1434	6	since	since	SCONJ
admet-292	1434	7	the	the	DET
admet-292	1434	8	initial	initial	ADJ
admet-292	1434	9	ph	ph	NOUN
admet-292	1434	10	about	about	ADP
admet-292	1434	11	1.9	1.9	NUM
admet-292	1434	12	,	,	PUNCT
admet-292	1434	13	adjustment	adjustment	NOUN
admet-292	1434	14	of	of	ADP
admet-292	1434	15	the	the	DET
admet-292	1434	16	buffer	buffer	NOUN
admet-292	1434	17	with	with	ADP
admet-292	1434	18	naoh	naoh	NOUN
admet-292	1434	19	titrant	titrant	NOUN
admet-292	1434	20	can	can	AUX
admet-292	1434	21	set	set	VERB
admet-292	1434	22	the	the	DET
admet-292	1434	23	ph	ph	NOUN
admet-292	1434	24	over	over	ADP
admet-292	1434	25	a	a	DET
admet-292	1434	26	wide	wide	ADJ
admet-292	1434	27	range	range	NOUN
admet-292	1434	28	.	.	PUNCT
admet-292	1435	1	as	as	SCONJ
admet-292	1435	2	figure	figure	NOUN
admet-292	1435	3	a1d	a1d	PROPN
admet-292	1435	4	shows	show	NOUN
admet-292	1435	5	,	,	PUNCT
admet-292	1435	6	the	the	DET
admet-292	1435	7	buffer	buffer	NOUN
admet-292	1435	8	capacity	capacity	NOUN
admet-292	1435	9	is	be	AUX
admet-292	1435	10	evened	even	VERB
admet-292	1435	11	out	out	ADP
admet-292	1435	12	to	to	ADP
admet-292	1435	13	an	an	DET
admet-292	1435	14	average	average	ADJ
admet-292	1435	15	value	value	NOUN
admet-292	1435	16	of	of	ADP
admet-292	1435	17	14.8	14.8	NUM
admet-292	1435	18	mm	mm	NOUN
admet-292	1435	19	/	/	SYM
admet-292	1435	20	ph	ph	NOUN
admet-292	1435	21	in	in	ADP
admet-292	1435	22	the	the	DET
admet-292	1435	23	ph	ph	ADJ
admet-292	1435	24	interval	interval	NOUN
admet-292	1435	25	from	from	ADP
admet-292	1435	26	3	3	NUM
admet-292	1435	27	to	to	ADP
admet-292	1435	28	11	11	NUM
admet-292	1435	29	,	,	PUNCT
admet-292	1435	30	which	which	PRON
admet-292	1435	31	is	be	AUX
admet-292	1435	32	a	a	DET
admet-292	1435	33	considerable	considerable	ADJ
admet-292	1435	34	improvement	improvement	NOUN
admet-292	1435	35	over	over	ADP
admet-292	1435	36	the	the	DET
admet-292	1435	37	simple	simple	ADJ
admet-292	1435	38	phosphate	phosphate	NOUN
admet-292	1435	39	buffer	buffer	NOUN
admet-292	1435	40	(	(	PUNCT
admet-292	1435	41	figure	figure	NOUN
admet-292	1435	42	a1b	a1b	PROPN
admet-292	1435	43	)	)	PUNCT
admet-292	1435	44	.	.	PUNCT
admet-292	1436	1	when	when	SCONJ
admet-292	1436	2	mass	mass	ADJ
admet-292	1436	3	spectrometry	spectrometry	NOUN
admet-292	1436	4	is	be	AUX
admet-292	1436	5	used	use	VERB
admet-292	1436	6	to	to	PART
admet-292	1436	7	measure	measure	VERB
admet-292	1436	8	concentrations	concentration	NOUN
admet-292	1436	9	,	,	PUNCT
admet-292	1436	10	the	the	DET
admet-292	1436	11	present	present	NOUN
admet-292	1436	12	of	of	ADP
admet-292	1436	13	phosphate	phosphate	NOUN
admet-292	1436	14	is	be	AUX
admet-292	1436	15	problematic	problematic	ADJ
admet-292	1436	16	.	.	PUNCT
admet-292	1437	1	also	also	ADV
admet-292	1437	2	,	,	PUNCT
admet-292	1437	3	if	if	SCONJ
admet-292	1437	4	the	the	DET
admet-292	1437	5	sample	sample	NOUN
admet-292	1437	6	contains	contain	VERB
admet-292	1437	7	1,2	1,2	NUM
admet-292	1437	8	-	-	PUNCT
admet-292	1437	9	diol	diol	NOUN
admet-292	1437	10	groups	group	NOUN
admet-292	1437	11	,	,	PUNCT
admet-292	1437	12	the	the	DET
admet-292	1437	13	boric	boric	ADJ
admet-292	1437	14	acid	acid	NOUN
admet-292	1437	15	may	may	AUX
admet-292	1437	16	form	form	VERB
admet-292	1437	17	covalent	covalent	ADJ
admet-292	1437	18	bonds	bond	NOUN
admet-292	1437	19	with	with	ADP
admet-292	1437	20	them	they	PRON
admet-292	1437	21	.	.	PUNCT
admet-292	1438	1	it	it	PRON
admet-292	1438	2	can	can	AUX
admet-292	1438	3	be	be	AUX
admet-292	1438	4	noted	note	VERB
admet-292	1438	5	that	that	SCONJ
admet-292	1438	6	the	the	DET
admet-292	1438	7	ionic	ionic	ADJ
admet-292	1438	8	strength	strength	NOUN
admet-292	1438	9	increases	increase	VERB
admet-292	1438	10	ten	ten	ADJ
admet-292	1438	11	-	-	ADJ
admet-292	1438	12	fold	fold	VERB
admet-292	1438	13	uniformly	uniformly	ADV
admet-292	1438	14	as	as	ADP
admet-292	1438	15	the	the	DET
admet-292	1438	16	ph	ph	NOUN
admet-292	1438	17	increase	increase	NOUN
admet-292	1438	18	from	from	ADP
admet-292	1438	19	2	2	NUM
admet-292	1438	20	to	to	ADP
admet-292	1438	21	11	11	NUM
admet-292	1438	22	(	(	PUNCT
admet-292	1438	23	0.02	0.02	NUM
admet-292	1438	24	to	to	PART
admet-292	1438	25	0.2	0.2	NUM
admet-292	1438	26	m	m	NOUN
admet-292	1438	27	)	)	PUNCT
admet-292	1438	28	,	,	PUNCT
admet-292	1438	29	which	which	PRON
admet-292	1438	30	should	should	AUX
admet-292	1438	31	not	not	PART
admet-292	1438	32	be	be	AUX
admet-292	1438	33	a	a	DET
admet-292	1438	34	problem	problem	NOUN
admet-292	1438	35	in	in	ADP
admet-292	1438	36	data	data	NOUN
admet-292	1438	37	analysis	analysis	NOUN
admet-292	1438	38	[	[	X
admet-292	1438	39	22	22	NUM
admet-292	1438	40	]	]	PUNCT
admet-292	1438	41	.	.	PUNCT
admet-292	1439	1	generally	generally	ADV
admet-292	1439	2	,	,	PUNCT
admet-292	1439	3	the	the	DET
admet-292	1439	4	britton	britton	PROPN
admet-292	1439	5	-	-	PUNCT
admet-292	1439	6	robinson	robinson	PROPN
admet-292	1439	7	buffer	buffer	NOUN
admet-292	1439	8	can	can	AUX
admet-292	1439	9	be	be	AUX
admet-292	1439	10	highly	highly	ADV
admet-292	1439	11	recommended	recommend	VERB
admet-292	1439	12	,	,	PUNCT
admet-292	1439	13	provided	provide	VERB
admet-292	1439	14	it	it	PRON
admet-292	1439	15	is	be	AUX
admet-292	1439	16	compatible	compatible	ADJ
admet-292	1439	17	with	with	ADP
admet-292	1439	18	the	the	DET
admet-292	1439	19	detection	detection	NOUN
admet-292	1439	20	method	method	NOUN
admet-292	1439	21	and	and	CCONJ
admet-292	1439	22	the	the	DET
admet-292	1439	23	chemistry	chemistry	NOUN
admet-292	1439	24	of	of	ADP
admet-292	1439	25	the	the	DET
admet-292	1439	26	sample	sample	NOUN
admet-292	1439	27	.	.	PUNCT
admet-292	1440	1	minimalist	minimalist	ADJ
admet-292	1440	2	universal	universal	ADJ
admet-292	1440	3	buffer	buffer	NOUN
admet-292	1440	4	(	(	PUNCT
admet-292	1440	5	mub	mub	NOUN
admet-292	1440	6	)	)	PUNCT
admet-292	1440	7	finding	find	VERB
admet-292	1440	8	ways	way	NOUN
admet-292	1440	9	to	to	PART
admet-292	1440	10	avoid	avoid	VERB
admet-292	1440	11	the	the	DET
admet-292	1440	12	chloride	chloride	NOUN
admet-292	1440	13	may	may	AUX
admet-292	1440	14	be	be	AUX
admet-292	1440	15	a	a	DET
admet-292	1440	16	good	good	ADJ
admet-292	1440	17	feature	feature	NOUN
admet-292	1440	18	when	when	SCONJ
admet-292	1440	19	studying	study	VERB
admet-292	1440	20	weaker	weak	ADJ
admet-292	1440	21	salt	salt	NOUN
admet-292	1440	22	formers	former	NOUN
admet-292	1440	23	of	of	ADP
admet-292	1440	24	drugs	drug	NOUN
admet-292	1440	25	.	.	PUNCT
admet-292	1441	1	in	in	ADP
admet-292	1441	2	cases	case	NOUN
admet-292	1441	3	where	where	SCONJ
admet-292	1441	4	chloride	chloride	NOUN
admet-292	1441	5	,	,	PUNCT
admet-292	1441	6	borate	borate	NOUN
admet-292	1441	7	,	,	PUNCT
admet-292	1441	8	and	and	CCONJ
admet-292	1441	9	phosphate	phosphate	ADJ
admet-292	1441	10	need	need	NOUN
admet-292	1441	11	to	to	PART
admet-292	1441	12	be	be	AUX
admet-292	1441	13	avoided	avoid	VERB
admet-292	1441	14	,	,	PUNCT
admet-292	1441	15	the	the	DET
admet-292	1441	16	“	"	PUNCT
admet-292	1441	17	aem-10.10.30	aem-10.10.30	PROPN
admet-292	1441	18	”	"	PUNCT
admet-292	1441	19	(	(	PUNCT
admet-292	1441	20	devised	devise	VERB
admet-292	1441	21	here	here	ADV
admet-292	1441	22	)	)	PUNCT
admet-292	1441	23	may	may	AUX
admet-292	1441	24	be	be	AUX
admet-292	1441	25	a	a	DET
admet-292	1441	26	alex	alex	PROPN
admet-292	1441	27	avdeef	avdeef	PROPN
admet-292	1441	28	et	et	PROPN
admet-292	1441	29	al	al	PROPN
admet-292	1441	30	.	.	PROPN
admet-292	1441	31	admet	admet	PROPN
admet-292	1441	32	&	&	CCONJ
admet-292	1441	33	dmpk	dmpk	PROPN
admet-292	1441	34	4(2	4(2	NUM
admet-292	1441	35	)	)	PUNCT
admet-292	1441	36	(	(	PUNCT
admet-292	1441	37	2016	2016	NUM
admet-292	1441	38	)	)	PUNCT
admet-292	1441	39	117	117	NUM
admet-292	1441	40	-	-	SYM
admet-292	1441	41	178	178	NUM
admet-292	1441	42	164	164	NUM
admet-292	1441	43	suitable	suitable	ADJ
admet-292	1441	44	universal	universal	ADJ
admet-292	1441	45	buffer	buffer	NOUN
admet-292	1441	46	(	(	PUNCT
admet-292	1441	47	figure	figure	NOUN
admet-292	1441	48	a1e	a1e	PROPN
admet-292	1441	49	)	)	PUNCT
admet-292	1441	50	.	.	PUNCT
admet-292	1442	1	the	the	DET
admet-292	1442	2	aem	aem	PROPN
admet-292	1442	3	buffer	buffer	NOUN
admet-292	1442	4	consists	consist	VERB
admet-292	1442	5	of	of	ADP
admet-292	1442	6	10	10	NUM
admet-292	1442	7	mm	mm	NOUN
admet-292	1442	8	acetic	acetic	ADJ
admet-292	1442	9	acid	acid	NOUN
admet-292	1442	10	,	,	PUNCT
admet-292	1442	11	10	10	NUM
admet-292	1442	12	mm	mm	NOUN
admet-292	1442	13	ethylenediamine	ethylenediamine	NOUN
admet-292	1442	14	,	,	PUNCT
admet-292	1442	15	and	and	CCONJ
admet-292	1442	16	30	30	NUM
admet-292	1442	17	mm	mm	NOUN
admet-292	1442	18	mesylic	mesylic	NOUN
admet-292	1442	19	acid	acid	NOUN
admet-292	1442	20	,	,	PUNCT
admet-292	1442	21	which	which	PRON
admet-292	1442	22	is	be	AUX
admet-292	1442	23	used	use	VERB
admet-292	1442	24	to	to	PART
admet-292	1442	25	adjust	adjust	VERB
admet-292	1442	26	the	the	DET
admet-292	1442	27	starting	starting	NOUN
admet-292	1442	28	ph	ph	NOUN
admet-292	1442	29	to	to	ADP
admet-292	1442	30	about	about	ADP
admet-292	1442	31	1.7	1.7	NUM
admet-292	1442	32	.	.	PUNCT
admet-292	1443	1	the	the	DET
admet-292	1443	2	buffer	buffer	NOUN
admet-292	1443	3	capacity	capacity	NOUN
admet-292	1443	4	is	be	AUX
admet-292	1443	5	nearly	nearly	ADV
admet-292	1443	6	as	as	ADV
admet-292	1443	7	uniformly	uniformly	ADV
admet-292	1443	8	distributed	distribute	VERB
admet-292	1443	9	as	as	ADP
admet-292	1443	10	in	in	ADP
admet-292	1443	11	the	the	DET
admet-292	1443	12	case	case	NOUN
admet-292	1443	13	of	of	ADP
admet-292	1443	14	the	the	DET
admet-292	1443	15	britton	britton	PROPN
admet-292	1443	16	-	-	PUNCT
admet-292	1443	17	robinson	robinson	PROPN
admet-292	1443	18	buffer	buffer	NOUN
admet-292	1443	19	,	,	PUNCT
admet-292	1443	20	but	but	CCONJ
admet-292	1443	21	a	a	DET
admet-292	1443	22	lower	low	ADJ
admet-292	1443	23	level	level	NOUN
admet-292	1443	24	is	be	AUX
admet-292	1443	25	chosen	choose	VERB
admet-292	1443	26	(	(	PUNCT
admet-292	1443	27	average	average	NOUN
admet-292	1443	28	of	of	ADP
admet-292	1443	29	4.4	4.4	NUM
admet-292	1443	30	mm	mm	NOUN
admet-292	1443	31	/	/	SYM
admet-292	1443	32	ph	ph	PROPN
admet-292	1443	33	over	over	ADP
admet-292	1443	34	ph	ph	ADJ
admet-292	1443	35	3	3	NUM
admet-292	1443	36	-	-	SYM
admet-292	1443	37	11	11	NUM
admet-292	1443	38	)	)	PUNCT
admet-292	1443	39	.	.	PUNCT
admet-292	1444	1	this	this	DET
admet-292	1444	2	buffer	buffer	NOUN
admet-292	1444	3	capacity	capacity	NOUN
admet-292	1444	4	would	would	AUX
admet-292	1444	5	allow	allow	VERB
admet-292	1444	6	the	the	DET
admet-292	1444	7	commercial	commercial	ADJ
admet-292	1444	8	pka	pka	PROPN
admet-292	1444	9	analyzers	analyzer	NOUN
admet-292	1444	10	to	to	PART
admet-292	1444	11	easily	easily	ADV
admet-292	1444	12	set	set	VERB
admet-292	1444	13	ph	ph	NOUN
admet-292	1444	14	in	in	ADP
admet-292	1444	15	increments	increment	NOUN
admet-292	1444	16	of	of	ADP
admet-292	1444	17	0.2	0.2	NUM
admet-292	1444	18	across	across	ADP
admet-292	1444	19	the	the	DET
admet-292	1444	20	ph	ph	ADJ
admet-292	1444	21	range	range	NOUN
admet-292	1444	22	,	,	PUNCT
admet-292	1444	23	using	use	VERB
admet-292	1444	24	0.5	0.5	NUM
admet-292	1444	25	m	m	NOUN
admet-292	1444	26	titrants	titrant	NOUN
admet-292	1444	27	.	.	PUNCT
admet-292	1445	1	in	in	ADP
admet-292	1445	2	that	that	DET
admet-292	1445	3	sense	sense	NOUN
admet-292	1445	4	,	,	PUNCT
admet-292	1445	5	the	the	DET
admet-292	1445	6	concentrations	concentration	NOUN
admet-292	1445	7	of	of	ADP
admet-292	1445	8	buffer	buffer	NOUN
admet-292	1445	9	components	component	NOUN
admet-292	1445	10	are	be	AUX
admet-292	1445	11	“	"	PUNCT
admet-292	1445	12	minimalist	minimalist	ADJ
admet-292	1445	13	”	"	PUNCT
admet-292	1445	14	–	–	PUNCT
admet-292	1445	15	being	be	AUX
admet-292	1445	16	just	just	ADV
admet-292	1445	17	right	right	ADJ
admet-292	1445	18	for	for	SCONJ
admet-292	1445	19	the	the	DET
admet-292	1445	20	titration	titration	NOUN
admet-292	1445	21	equipment	equipment	NOUN
admet-292	1445	22	used	use	VERB
admet-292	1445	23	.	.	PUNCT
admet-292	1446	1	because	because	SCONJ
admet-292	1446	2	the	the	DET
admet-292	1446	3	universal	universal	ADJ
admet-292	1446	4	buffer	buffer	NOUN
admet-292	1446	5	is	be	AUX
admet-292	1446	6	a	a	DET
admet-292	1446	7	combination	combination	NOUN
admet-292	1446	8	of	of	ADP
admet-292	1446	9	an	an	DET
admet-292	1446	10	acid	acid	NOUN
admet-292	1446	11	and	and	CCONJ
admet-292	1446	12	a	a	DET
admet-292	1446	13	base	base	NOUN
admet-292	1446	14	,	,	PUNCT
admet-292	1446	15	the	the	DET
admet-292	1446	16	ionic	ionic	ADJ
admet-292	1446	17	strength	strength	NOUN
admet-292	1446	18	remains	remain	VERB
admet-292	1446	19	nearly	nearly	ADV
admet-292	1446	20	constant	constant	ADJ
admet-292	1446	21	across	across	ADP
admet-292	1446	22	the	the	DET
admet-292	1446	23	working	work	VERB
admet-292	1446	24	ph	ph	ADJ
admet-292	1446	25	range	range	NOUN
admet-292	1446	26	,	,	PUNCT
admet-292	1446	27	which	which	PRON
admet-292	1446	28	is	be	AUX
admet-292	1446	29	unique	unique	ADJ
admet-292	1446	30	among	among	ADP
admet-292	1446	31	the	the	DET
admet-292	1446	32	common	common	ADJ
admet-292	1446	33	universal	universal	ADJ
admet-292	1446	34	buffers	buffer	NOUN
admet-292	1446	35	,	,	PUNCT
admet-292	1446	36	and	and	CCONJ
admet-292	1446	37	is	be	AUX
admet-292	1446	38	particularly	particularly	ADV
admet-292	1446	39	well	well	ADV
admet-292	1446	40	suited	suited	ADJ
admet-292	1446	41	for	for	ADP
admet-292	1446	42	solubility	solubility	NOUN
admet-292	1446	43	applications	application	NOUN
admet-292	1446	44	.	.	PUNCT
admet-292	1447	1	a	a	DET
admet-292	1447	2	buffer	buffer	NOUN
admet-292	1447	3	similar	similar	ADJ
admet-292	1447	4	to	to	ADP
admet-292	1447	5	the	the	DET
admet-292	1447	6	aem	aem	PROPN
admet-292	1447	7	,	,	PUNCT
admet-292	1447	8	consisting	consist	VERB
admet-292	1447	9	of	of	ADP
admet-292	1447	10	lactic	lactic	ADJ
admet-292	1447	11	acid	acid	NOUN
admet-292	1447	12	and	and	CCONJ
admet-292	1447	13	ethylenediamine	ethylenediamine	NOUN
admet-292	1447	14	,	,	PUNCT
admet-292	1447	15	has	have	AUX
admet-292	1447	16	been	be	AUX
admet-292	1447	17	successfully	successfully	ADV
admet-292	1447	18	tested	test	VERB
admet-292	1447	19	[	[	PUNCT
admet-292	1447	20	114	114	NUM
admet-292	1447	21	]	]	PUNCT
admet-292	1447	22	.	.	PUNCT
admet-292	1448	1	as	as	ADP
admet-292	1448	2	oil	oil	NOUN
admet-292	1448	3	,	,	PUNCT
admet-292	1448	4	ethylenediamine	ethylenediamine	PROPN
admet-292	1448	5	may	may	AUX
admet-292	1448	6	not	not	PART
admet-292	1448	7	be	be	AUX
admet-292	1448	8	convenient	convenient	ADJ
admet-292	1448	9	to	to	PART
admet-292	1448	10	work	work	VERB
admet-292	1448	11	with	with	ADP
admet-292	1448	12	.	.	PUNCT
admet-292	1449	1	to	to	PART
admet-292	1449	2	remain	remain	VERB
admet-292	1449	3	chloride	chloride	NOUN
admet-292	1449	4	-	-	PUNCT
admet-292	1449	5	free	free	ADJ
admet-292	1449	6	,	,	PUNCT
admet-292	1449	7	alternatively	alternatively	ADV
admet-292	1449	8	,	,	PUNCT
admet-292	1449	9	it	it	PRON
admet-292	1449	10	may	may	AUX
admet-292	1449	11	be	be	AUX
admet-292	1449	12	useful	useful	ADJ
admet-292	1449	13	to	to	PART
admet-292	1449	14	form	form	VERB
admet-292	1449	15	a	a	DET
admet-292	1449	16	dimesylate	dimesylate	NOUN
admet-292	1449	17	or	or	CCONJ
admet-292	1449	18	diacetate	diacetate	ADJ
admet-292	1449	19	salt	salt	NOUN
admet-292	1449	20	from	from	ADP
admet-292	1449	21	ethylenediamine	ethylenediamine	PROPN
admet-292	1449	22	free	free	ADJ
admet-292	1449	23	base	base	NOUN
admet-292	1449	24	and	and	CCONJ
admet-292	1449	25	either	either	CCONJ
admet-292	1449	26	mesylic	mesylic	ADJ
admet-292	1449	27	or	or	CCONJ
admet-292	1449	28	trifluroacetic	trifluroacetic	ADJ
admet-292	1449	29	acid	acid	NOUN
admet-292	1449	30	.	.	PUNCT
admet-292	1450	1	mass	mass	PROPN
admet-292	1450	2	spectrometry	spectrometry	NOUN
admet-292	1450	3	-	-	PUNCT
admet-292	1450	4	friendly	friendly	ADJ
admet-292	1450	5	minimalist	minimalist	ADJ
admet-292	1450	6	universal	universal	ADJ
admet-292	1450	7	buffer	buffer	NOUN
admet-292	1450	8	(	(	PUNCT
admet-292	1450	9	ms	ms	NOUN
admet-292	1450	10	-	-	PUNCT
admet-292	1450	11	mub	mub	NOUN
admet-292	1450	12	)	)	PUNCT
admet-292	1450	13	in	in	ADP
admet-292	1450	14	the	the	DET
admet-292	1450	15	aem-10.10.30	aem-10.10.30	PROPN
admet-292	1450	16	buffer	buffer	PROPN
admet-292	1450	17	design	design	NOUN
admet-292	1450	18	,	,	PUNCT
admet-292	1450	19	mesylic	mesylic	ADJ
admet-292	1450	20	acid	acid	NOUN
admet-292	1450	21	is	be	AUX
admet-292	1450	22	proposed	propose	VERB
admet-292	1450	23	to	to	PART
admet-292	1450	24	set	set	VERB
admet-292	1450	25	the	the	DET
admet-292	1450	26	initial	initial	ADJ
admet-292	1450	27	ph	ph	NOUN
admet-292	1450	28	to	to	ADP
admet-292	1450	29	1.7	1.7	NUM
admet-292	1450	30	.	.	PUNCT
admet-292	1451	1	however	however	ADV
admet-292	1451	2	,	,	PUNCT
admet-292	1451	3	mesylic	mesylic	ADJ
admet-292	1451	4	acid	acid	NOUN
admet-292	1451	5	is	be	AUX
admet-292	1451	6	not	not	PART
admet-292	1451	7	compatible	compatible	ADJ
admet-292	1451	8	with	with	ADP
admet-292	1451	9	mass	mass	ADJ
admet-292	1451	10	spectrometer	spectrometer	NOUN
admet-292	1451	11	use	use	NOUN
admet-292	1451	12	.	.	PUNCT
admet-292	1452	1	aet-25.25.75	aet-25.25.75	X
admet-292	1452	2	(	(	PUNCT
admet-292	1452	3	25	25	NUM
admet-292	1452	4	mm	mm	NOUN
admet-292	1452	5	acetic	acetic	ADJ
admet-292	1452	6	acid	acid	NOUN
admet-292	1452	7	,	,	PUNCT
admet-292	1452	8	25	25	NUM
admet-292	1452	9	mm	mm	NOUN
admet-292	1452	10	ethylenediamine	ethylenediamine	NOUN
admet-292	1452	11	,	,	PUNCT
admet-292	1452	12	75	75	NUM
admet-292	1452	13	mm	mm	NOUN
admet-292	1452	14	trifluroacetic	trifluroacetic	ADJ
admet-292	1452	15	acid	acid	NOUN
admet-292	1452	16	)	)	PUNCT
admet-292	1452	17	was	be	AUX
admet-292	1452	18	formulated	formulate	VERB
admet-292	1452	19	to	to	PART
admet-292	1452	20	be	be	AUX
admet-292	1452	21	ms	ms	ADJ
admet-292	1452	22	-	-	PUNCT
admet-292	1452	23	friendly	friendly	ADJ
admet-292	1452	24	,	,	PUNCT
admet-292	1452	25	higher	high	ADJ
admet-292	1452	26	-	-	PUNCT
admet-292	1452	27	capacity	capacity	NOUN
admet-292	1452	28	version	version	NOUN
admet-292	1452	29	of	of	ADP
admet-292	1452	30	the	the	DET
admet-292	1452	31	aem	aem	NOUN
admet-292	1452	32	buffer	buffer	NOUN
admet-292	1452	33	.	.	PUNCT
admet-292	1453	1	figure	figure	NOUN
admet-292	1453	2	a1f	a1f	PROPN
admet-292	1453	3	shows	show	VERB
admet-292	1453	4	the	the	DET
admet-292	1453	5	buffer	buffer	NOUN
admet-292	1453	6	capacity	capacity	NOUN
admet-292	1453	7	and	and	CCONJ
admet-292	1453	8	ionic	ionic	ADJ
admet-292	1453	9	strength	strength	NOUN
admet-292	1453	10	as	as	ADP
admet-292	1453	11	a	a	DET
admet-292	1453	12	function	function	NOUN
admet-292	1453	13	of	of	ADP
admet-292	1453	14	ph	ph	ADJ
admet-292	1453	15	capacity	capacity	NOUN
admet-292	1453	16	,	,	PUNCT
admet-292	1453	17	with	with	ADP
admet-292	1453	18	average	average	ADJ
admet-292	1453	19	values	value	NOUN
admet-292	1453	20	of	of	ADP
admet-292	1453	21	8.3	8.3	NUM
admet-292	1453	22	mm	mm	NOUN
admet-292	1453	23	/	/	SYM
admet-292	1453	24	ph	ph	PROPN
admet-292	1453	25	and	and	CCONJ
admet-292	1453	26	0.096	0.096	NUM
admet-292	1453	27	m	m	NOUN
admet-292	1453	28	,	,	PUNCT
admet-292	1453	29	respectively	respectively	ADV
admet-292	1453	30	.	.	PUNCT
admet-292	1454	1	excessive	excessive	ADJ
admet-292	1454	2	dilution	dilution	NOUN
admet-292	1454	3	effects	effect	NOUN
admet-292	1454	4	due	due	ADJ
admet-292	1454	5	to	to	ADP
admet-292	1454	6	titrant	titrant	NOUN
admet-292	1454	7	addition	addition	NOUN
admet-292	1454	8	would	would	AUX
admet-292	1454	9	not	not	PART
admet-292	1454	10	favor	favor	VERB
admet-292	1454	11	higher	high	ADJ
admet-292	1454	12	buffer	buffer	NOUN
admet-292	1454	13	capacity	capacity	NOUN
admet-292	1454	14	versions	version	NOUN
admet-292	1454	15	.	.	PUNCT
admet-292	1455	1	titration	titration	NOUN
admet-292	1455	2	curves	curve	NOUN
admet-292	1455	3	and	and	CCONJ
admet-292	1455	4	the	the	DET
admet-292	1455	5	incrementing	incrementing	NOUN
admet-292	1455	6	of	of	ADP
admet-292	1455	7	ph	ph	NOUN
admet-292	1455	8	by	by	ADP
admet-292	1455	9	titrant	titrant	NOUN
admet-292	1455	10	additions	addition	NOUN
admet-292	1455	11	figures	figure	NOUN
admet-292	1455	12	a2	a2	PROPN
admet-292	1455	13	show	show	VERB
admet-292	1455	14	the	the	DET
admet-292	1455	15	titration	titration	NOUN
admet-292	1455	16	curves	curve	NOUN
admet-292	1455	17	for	for	ADP
admet-292	1455	18	four	four	NUM
admet-292	1455	19	of	of	ADP
admet-292	1455	20	the	the	DET
admet-292	1455	21	above	above	ADJ
admet-292	1455	22	cases	case	NOUN
admet-292	1455	23	.	.	PUNCT
admet-292	1456	1	figure	figure	NOUN
admet-292	1456	2	a2a	a2a	PROPN
admet-292	1456	3	shows	show	VERB
admet-292	1456	4	that	that	SCONJ
admet-292	1456	5	the	the	DET
admet-292	1456	6	ph	ph	ADJ
admet-292	1456	7	adjustment	adjustment	NOUN
admet-292	1456	8	across	across	ADP
admet-292	1456	9	the	the	DET
admet-292	1456	10	steep	steep	ADJ
admet-292	1456	11	ph	ph	ADJ
admet-292	1456	12	3	3	NUM
admet-292	1456	13	-	-	SYM
admet-292	1456	14	11	11	NUM
admet-292	1456	15	region	region	NOUN
admet-292	1456	16	in	in	ADP
admet-292	1456	17	the	the	DET
admet-292	1456	18	“	"	PUNCT
admet-292	1456	19	blank	blank	ADJ
admet-292	1456	20	”	"	PUNCT
admet-292	1456	21	titration	titration	NOUN
admet-292	1456	22	would	would	AUX
admet-292	1456	23	be	be	AUX
admet-292	1456	24	difficult	difficult	ADJ
admet-292	1456	25	to	to	PART
admet-292	1456	26	achieve	achieve	VERB
admet-292	1456	27	with	with	ADP
admet-292	1456	28	normal	normal	ADJ
admet-292	1456	29	titration	titration	NOUN
admet-292	1456	30	equipment	equipment	NOUN
admet-292	1456	31	and	and	CCONJ
admet-292	1456	32	titrant	titrant	NOUN
admet-292	1456	33	concentrations	concentration	NOUN
admet-292	1456	34	,	,	PUNCT
admet-292	1456	35	if	if	SCONJ
admet-292	1456	36	0.2	0.2	NUM
admet-292	1456	37	ph	ph	ADJ
admet-292	1456	38	increments	increment	NOUN
admet-292	1456	39	were	be	AUX
admet-292	1456	40	desired	desire	VERB
admet-292	1456	41	.	.	PUNCT
admet-292	1457	1	by	by	ADP
admet-292	1457	2	selecting	select	VERB
admet-292	1457	3	the	the	DET
admet-292	1457	4	50	50	NUM
admet-292	1457	5	mm	mm	NOUN
admet-292	1457	6	phosphate	phosphate	NOUN
admet-292	1457	7	buffer	buffer	NOUN
admet-292	1457	8	,	,	PUNCT
admet-292	1457	9	the	the	DET
admet-292	1457	10	steepness	steepness	NOUN
admet-292	1457	11	in	in	ADP
admet-292	1457	12	the	the	DET
admet-292	1457	13	working	work	VERB
admet-292	1457	14	ph	ph	ADJ
admet-292	1457	15	range	range	NOUN
admet-292	1457	16	is	be	AUX
admet-292	1457	17	lessened	lessen	VERB
admet-292	1457	18	,	,	PUNCT
admet-292	1457	19	and	and	CCONJ
admet-292	1457	20	it	it	PRON
admet-292	1457	21	should	should	AUX
admet-292	1457	22	be	be	AUX
admet-292	1457	23	possible	possible	ADJ
admet-292	1457	24	to	to	PART
admet-292	1457	25	control	control	VERB
admet-292	1457	26	ph	ph	ADJ
admet-292	1457	27	adjustment	adjustment	NOUN
admet-292	1457	28	with	with	ADP
admet-292	1457	29	the	the	DET
admet-292	1457	30	usual	usual	ADJ
admet-292	1457	31	equipment	equipment	NOUN
admet-292	1457	32	.	.	PUNCT
admet-292	1458	1	it	it	PRON
admet-292	1458	2	gets	get	VERB
admet-292	1458	3	much	much	ADV
admet-292	1458	4	easier	easy	ADJ
admet-292	1458	5	with	with	ADP
admet-292	1458	6	the	the	DET
admet-292	1458	7	virtually	virtually	ADV
admet-292	1458	8	linear	linear	ADJ
admet-292	1458	9	titration	titration	NOUN
admet-292	1458	10	curve	curve	NOUN
admet-292	1458	11	produced	produce	VERB
admet-292	1458	12	with	with	ADP
admet-292	1458	13	the	the	DET
admet-292	1458	14	britton	britton	PROPN
admet-292	1458	15	-	-	PUNCT
admet-292	1458	16	robinson	robinson	PROPN
admet-292	1458	17	universal	universal	ADJ
admet-292	1458	18	buffer	buffer	NOUN
admet-292	1458	19	(	(	PUNCT
admet-292	1458	20	figure	figure	NOUN
admet-292	1458	21	a2c	a2c	VERB
admet-292	1458	22	)	)	PUNCT
admet-292	1458	23	.	.	PUNCT
admet-292	1459	1	the	the	DET
admet-292	1459	2	linearized	linearize	VERB
admet-292	1459	3	titration	titration	NOUN
admet-292	1459	4	curve	curve	NOUN
admet-292	1459	5	in	in	ADP
admet-292	1459	6	figure	figure	NOUN
admet-292	1459	7	a2d	a2d	PROPN
admet-292	1459	8	for	for	ADP
admet-292	1459	9	the	the	DET
admet-292	1459	10	minimalist	minimalist	ADJ
admet-292	1459	11	universal	universal	ADJ
admet-292	1459	12	buffer	buffer	NOUN
admet-292	1459	13	,	,	PUNCT
admet-292	1459	14	aem-10.10.30	aem-10.10.30	PROPN
admet-292	1459	15	,	,	PUNCT
admet-292	1459	16	is	be	AUX
admet-292	1459	17	nearly	nearly	ADV
admet-292	1459	18	as	as	ADV
admet-292	1459	19	attractive	attractive	ADJ
admet-292	1459	20	as	as	ADP
admet-292	1459	21	that	that	PRON
admet-292	1459	22	of	of	ADP
admet-292	1459	23	the	the	DET
admet-292	1459	24	britton	britton	PROPN
admet-292	1459	25	-	-	PUNCT
admet-292	1459	26	robinson	robinson	PROPN
admet-292	1459	27	buffer	buffer	NOUN
admet-292	1459	28	.	.	PUNCT
admet-292	1460	1	aet-25.25.75	aet-25.25.75	PROPN
admet-292	1460	2	looks	look	VERB
admet-292	1460	3	similar	similar	ADJ
admet-292	1460	4	to	to	ADP
admet-292	1460	5	the	the	DET
admet-292	1460	6	aem	aem	NOUN
admet-292	1460	7	buffer	buffer	NOUN
admet-292	1460	8	.	.	PUNCT
admet-292	1461	1	possible	possible	ADJ
admet-292	1461	2	uses	use	NOUN
admet-292	1461	3	of	of	ADP
admet-292	1461	4	the	the	DET
admet-292	1461	5	minimalist	minimalist	ADJ
admet-292	1461	6	universal	universal	ADJ
admet-292	1461	7	buffer	buffer	NOUN
admet-292	1461	8	figure	figure	NOUN
admet-292	1461	9	a3	a3	NOUN
admet-292	1461	10	shows	show	VERB
admet-292	1461	11	the	the	DET
admet-292	1461	12	expected	expect	VERB
admet-292	1461	13	titration	titration	NOUN
admet-292	1461	14	curve	curve	NOUN
admet-292	1461	15	for	for	ADP
admet-292	1461	16	haloperidol	haloperidol	PROPN
admet-292	1461	17	(	(	PUNCT
admet-292	1461	18	free	free	ADJ
admet-292	1461	19	base	base	NOUN
admet-292	1461	20	)	)	PUNCT
admet-292	1461	21	in	in	ADP
admet-292	1461	22	aem-10.10.30	aem-10.10.30	PROPN
admet-292	1461	23	buffer	buffer	NOUN
admet-292	1461	24	,	,	PUNCT
admet-292	1461	25	titrated	titrate	VERB
admet-292	1461	26	with	with	ADP
admet-292	1461	27	0.5	0.5	NUM
admet-292	1461	28	m	m	PROPN
admet-292	1461	29	mesylic	mesylic	ADJ
admet-292	1461	30	acid	acid	NOUN
admet-292	1461	31	(	(	PUNCT
admet-292	1461	32	cf	cf	NOUN
admet-292	1461	33	.	.	PUNCT
admet-292	1461	34	,	,	PUNCT
admet-292	1461	35	figure	figure	NOUN
admet-292	1461	36	3a	3a	NUM
admet-292	1461	37	)	)	PUNCT
admet-292	1461	38	.	.	PUNCT
admet-292	1462	1	haloperidol	haloperidol	VERB
admet-292	1462	2	itself	itself	PRON
admet-292	1462	3	provides	provide	VERB
admet-292	1462	4	good	good	ADJ
admet-292	1462	5	buffering	buffering	NOUN
admet-292	1462	6	below	below	ADP
admet-292	1462	7	ph	ph	PROPN
admet-292	1462	8	5	5	NUM
admet-292	1462	9	.	.	PUNCT
admet-292	1462	10	above	above	ADP
admet-292	1462	11	ph	ph	PROPN
admet-292	1462	12	5	5	NUM
admet-292	1462	13	,	,	PUNCT
admet-292	1462	14	the	the	DET
admet-292	1462	15	titration	titration	NOUN
admet-292	1462	16	curve	curve	NOUN
admet-292	1462	17	would	would	AUX
admet-292	1462	18	have	have	AUX
admet-292	1462	19	been	be	AUX
admet-292	1462	20	too	too	ADV
admet-292	1462	21	steep	steep	ADJ
admet-292	1462	22	,	,	PUNCT
admet-292	1462	23	were	be	AUX
admet-292	1462	24	it	it	PRON
admet-292	1462	25	not	not	PART
admet-292	1462	26	for	for	ADP
admet-292	1462	27	the	the	DET
admet-292	1462	28	buffering	buffering	NOUN
admet-292	1462	29	action	action	NOUN
admet-292	1462	30	of	of	ADP
admet-292	1462	31	the	the	DET
admet-292	1462	32	aem	aem	NOUN
admet-292	1462	33	buffer	buffer	NOUN
admet-292	1462	34	.	.	PUNCT
admet-292	1463	1	the	the	DET
admet-292	1463	2	region	region	NOUN
admet-292	1463	3	from	from	ADP
admet-292	1463	4	ph	ph	PROPN
admet-292	1463	5	5	5	NUM
admet-292	1463	6	to	to	PART
admet-292	1463	7	12	12	NUM
admet-292	1463	8	is	be	AUX
admet-292	1463	9	sufficiently	sufficiently	ADV
admet-292	1463	10	buffered	buffer	VERB
admet-292	1463	11	,	,	PUNCT
admet-292	1463	12	so	so	SCONJ
admet-292	1463	13	that	that	SCONJ
admet-292	1463	14	ph	ph	ADJ
admet-292	1463	15	increments	increment	NOUN
admet-292	1463	16	of	of	ADP
admet-292	1463	17	0.2	0.2	NUM
admet-292	1463	18	could	could	AUX
admet-292	1463	19	be	be	AUX
admet-292	1463	20	achieved	achieve	VERB
admet-292	1463	21	by	by	ADP
admet-292	1463	22	0.5	0.5	NUM
admet-292	1463	23	m	m	NOUN
admet-292	1463	24	titrant	titrant	ADJ
admet-292	1463	25	minimum	minimum	NOUN
admet-292	1463	26	volume	volume	NOUN
admet-292	1463	27	additions	addition	NOUN
admet-292	1463	28	.	.	PUNCT
admet-292	1464	1	this	this	PRON
admet-292	1464	2	is	be	AUX
admet-292	1464	3	an	an	DET
admet-292	1464	4	example	example	NOUN
admet-292	1464	5	of	of	ADP
admet-292	1464	6	a	a	DET
admet-292	1464	7	“	"	PUNCT
admet-292	1464	8	minimalist	minimalist	ADJ
admet-292	1464	9	”	"	PUNCT
admet-292	1464	10	buffer	buffer	NOUN
admet-292	1464	11	,	,	PUNCT
admet-292	1464	12	which	which	PRON
admet-292	1464	13	provides	provide	VERB
admet-292	1464	14	a	a	DET
admet-292	1464	15	boost	boost	NOUN
admet-292	1464	16	where	where	SCONJ
admet-292	1464	17	needed	need	VERB
admet-292	1464	18	,	,	PUNCT
admet-292	1464	19	but	but	CCONJ
admet-292	1464	20	otherwise	otherwise	ADV
admet-292	1464	21	stays	stay	VERB
admet-292	1464	22	minimally	minimally	ADV
admet-292	1464	23	intrusive	intrusive	ADJ
admet-292	1464	24	.	.	PUNCT
admet-292	1465	1	admet	admet	PROPN
admet-292	1465	2	&	&	CCONJ
admet-292	1465	3	dmpk	dmpk	PROPN
admet-292	1465	4	4(2	4(2	NUM
admet-292	1465	5	)	)	PUNCT
admet-292	1465	6	(	(	PUNCT
admet-292	1465	7	2016	2016	NUM
admet-292	1465	8	)	)	PUNCT
admet-292	1465	9	117	117	NUM
admet-292	1465	10	-	-	SYM
admet-292	1465	11	178	178	NUM
admet-292	1465	12	consensus	consensus	NOUN
admet-292	1465	13	recommendations	recommendation	NOUN
admet-292	1465	14	for	for	ADP
admet-292	1465	15	improving	improve	VERB
admet-292	1465	16	solubility	solubility	NOUN
admet-292	1465	17	-	-	PUNCT
admet-292	1465	18	ph	ph	ADJ
admet-292	1465	19	data	datum	NOUN
admet-292	1465	20	quality	quality	NOUN
admet-292	1465	21	doi	doi	NOUN
admet-292	1465	22	:	:	PUNCT
admet-292	1465	23	10.5599	10.5599	NUM
admet-292	1465	24	/	/	SYM
admet-292	1465	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1465	26	165	165	NUM
admet-292	1465	27	figure	figure	NOUN
admet-292	1465	28	a2	a2	PROPN
admet-292	1465	29	.	.	PUNCT
admet-292	1466	1	titration	titration	NOUN
admet-292	1466	2	curves	curve	NOUN
admet-292	1466	3	for	for	ADP
admet-292	1466	4	four	four	NUM
admet-292	1466	5	of	of	ADP
admet-292	1466	6	the	the	DET
admet-292	1466	7	examples	example	NOUN
admet-292	1466	8	in	in	ADP
admet-292	1466	9	figure	figure	NOUN
admet-292	1466	10	a1	a1	NOUN
admet-292	1466	11	.	.	PUNCT
admet-292	1467	1	see	see	VERB
admet-292	1467	2	text	text	NOUN
admet-292	1467	3	.	.	PUNCT
admet-292	1468	1	figure	figure	NOUN
admet-292	1468	2	a3	a3	NOUN
admet-292	1468	3	.	.	PUNCT
admet-292	1469	1	examples	example	NOUN
admet-292	1469	2	of	of	ADP
admet-292	1469	3	titrations	titration	NOUN
admet-292	1469	4	of	of	ADP
admet-292	1469	5	haloperidol	haloperidol	NOUN
admet-292	1469	6	in	in	ADP
admet-292	1469	7	the	the	DET
admet-292	1469	8	aem	aem	NOUN
admet-292	1469	9	minimalist	minimalist	ADJ
admet-292	1469	10	buffer	buffer	NOUN
admet-292	1469	11	at	at	ADP
admet-292	1469	12	two	two	NUM
admet-292	1469	13	different	different	ADJ
admet-292	1469	14	concentrations	concentration	NOUN
admet-292	1469	15	of	of	ADP
admet-292	1469	16	buffer	buffer	NOUN
admet-292	1469	17	components	component	NOUN
admet-292	1469	18	.	.	PUNCT
admet-292	1470	1	alex	alex	PROPN
admet-292	1470	2	avdeef	avdeef	PROPN
admet-292	1470	3	et	et	PROPN
admet-292	1470	4	al	al	PROPN
admet-292	1470	5	.	.	PROPN
admet-292	1470	6	admet	admet	PROPN
admet-292	1470	7	&	&	CCONJ
admet-292	1470	8	dmpk	dmpk	PROPN
admet-292	1470	9	4(2	4(2	NUM
admet-292	1470	10	)	)	PUNCT
admet-292	1470	11	(	(	PUNCT
admet-292	1470	12	2016	2016	NUM
admet-292	1470	13	)	)	PUNCT
admet-292	1470	14	117	117	NUM
admet-292	1470	15	-	-	SYM
admet-292	1470	16	178	178	NUM
admet-292	1470	17	166	166	NUM
admet-292	1470	18	appendix	appendix	NOUN
admet-292	1470	19	b	b	X
admet-292	1470	20	–	–	PUNCT
admet-292	1470	21	simple	simple	ADJ
admet-292	1470	22	henderson	henderson	PROPN
admet-292	1470	23	-	-	PUNCT
admet-292	1470	24	hasselbalch	hasselbalch	PROPN
admet-292	1470	25	equations	equation	NOUN
admet-292	1470	26	the	the	DET
admet-292	1470	27	relationship	relationship	NOUN
admet-292	1470	28	between	between	ADP
admet-292	1470	29	solubility	solubility	NOUN
admet-292	1470	30	and	and	CCONJ
admet-292	1470	31	ph	ph	NOUN
admet-292	1470	32	can	can	AUX
admet-292	1470	33	be	be	AUX
admet-292	1470	34	easily	easily	ADV
admet-292	1470	35	derived	derive	VERB
admet-292	1470	36	for	for	ADP
admet-292	1470	37	a	a	DET
admet-292	1470	38	given	give	VERB
admet-292	1470	39	equilibrium	equilibrium	NOUN
admet-292	1470	40	model	model	NOUN
admet-292	1470	41	.	.	PUNCT
admet-292	1471	1	for	for	ADP
admet-292	1471	2	example	example	NOUN
admet-292	1471	3	,	,	PUNCT
admet-292	1471	4	in	in	ADP
admet-292	1471	5	the	the	DET
admet-292	1471	6	case	case	NOUN
admet-292	1471	7	of	of	ADP
admet-292	1471	8	a	a	DET
admet-292	1471	9	simple	simple	ADJ
admet-292	1471	10	monoprotic	monoprotic	ADJ
admet-292	1471	11	base	base	NOUN
admet-292	1471	12	,	,	PUNCT
admet-292	1471	13	a	a	DET
admet-292	1471	14	saturated	saturate	VERB
admet-292	1471	15	solution	solution	NOUN
admet-292	1471	16	can	can	AUX
admet-292	1471	17	be	be	AUX
admet-292	1471	18	defined	define	VERB
admet-292	1471	19	by	by	ADP
admet-292	1471	20	two	two	NUM
admet-292	1471	21	equations	equation	NOUN
admet-292	1471	22	and	and	CCONJ
admet-292	1471	23	the	the	DET
admet-292	1471	24	corresponding	corresponding	ADJ
admet-292	1471	25	constants	constant	NOUN
admet-292	1471	26	:	:	PUNCT
admet-292	1471	27	bh+	bh+	NOUN
admet-292	1471	28			NOUN
admet-292	1471	29	h+	h+	X
admet-292	1472	1	+	+	SYM
admet-292	1472	2	b	b	X
admet-292	1472	3	ka	ka	NOUN
admet-292	1472	4	=	=	PUNCT
admet-292	1473	1	[	[	X
admet-292	1473	2	h+][b	h+][b	X
admet-292	1473	3	]	]	X
admet-292	1473	4	/	/	PUNCT
admet-292	1473	5	[	[	X
admet-292	1473	6	bh+	bh+	NOUN
admet-292	1473	7	]	]	PUNCT
admet-292	1473	8	(	(	PUNCT
admet-292	1473	9	b.1a	b.1a	NOUN
admet-292	1473	10	)	)	PUNCT
admet-292	1473	11	b(s	b(	NOUN
admet-292	1473	12	)	)	PUNCT
admet-292	1473	13			X
admet-292	1474	1	b	b	X
admet-292	1474	2	s0	s0	X
admet-292	1474	3	=	=	PUNCT
admet-292	1475	1	[	[	X
admet-292	1475	2	b	b	X
admet-292	1475	3	]	]	X
admet-292	1475	4	(	(	PUNCT
admet-292	1475	5	b.1b	b.1b	NOUN
admet-292	1475	6	)	)	PUNCT
admet-292	1475	7	s0	s0	PROPN
admet-292	1475	8	is	be	AUX
admet-292	1475	9	the	the	DET
admet-292	1475	10	intrinsic	intrinsic	ADJ
admet-292	1475	11	solubility	solubility	NOUN
admet-292	1475	12	(	(	PUNCT
admet-292	1475	13	of	of	ADP
admet-292	1475	14	the	the	DET
admet-292	1475	15	free	free	ADJ
admet-292	1475	16	base	base	NOUN
admet-292	1475	17	at	at	ADP
admet-292	1475	18	ph	ph	PROPN
admet-292	1475	19	>	>	PUNCT
admet-292	1475	20	>	>	X
admet-292	1475	21	pka	pka	PROPN
admet-292	1475	22	)	)	PUNCT
admet-292	1475	23	.	.	PUNCT
admet-292	1476	1	at	at	ADP
admet-292	1476	2	a	a	DET
admet-292	1476	3	particular	particular	ADJ
admet-292	1476	4	ph	ph	NOUN
admet-292	1476	5	,	,	PUNCT
admet-292	1476	6	solubility	solubility	NOUN
admet-292	1476	7	is	be	AUX
admet-292	1476	8	defined	define	VERB
admet-292	1476	9	as	as	ADP
admet-292	1476	10	the	the	DET
admet-292	1476	11	mass	mass	NOUN
admet-292	1476	12	balance	balance	NOUN
admet-292	1476	13	sum	sum	NOUN
admet-292	1476	14	of	of	ADP
admet-292	1476	15	the	the	DET
admet-292	1476	16	concentrations	concentration	NOUN
admet-292	1476	17	of	of	ADP
admet-292	1476	18	all	all	PRON
admet-292	1476	19	of	of	ADP
admet-292	1476	20	the	the	DET
admet-292	1476	21	species	specie	NOUN
admet-292	1476	22	dissolved	dissolve	VERB
admet-292	1476	23	in	in	ADP
admet-292	1476	24	the	the	DET
admet-292	1476	25	aqueous	aqueous	ADJ
admet-292	1476	26	phase	phase	NOUN
admet-292	1476	27	:	:	PUNCT
admet-292	1476	28	s	s	VERB
admet-292	1476	29	=	=	PUNCT
admet-292	1477	1	[	[	X
admet-292	1477	2	bh	bh	NOUN
admet-292	1477	3	+	+	X
admet-292	1477	4	]	]	PUNCT
admet-292	1478	1	+	+	CCONJ
admet-292	1478	2	[	[	X
admet-292	1478	3	b	b	X
admet-292	1478	4	]	]	X
admet-292	1478	5	(	(	PUNCT
admet-292	1478	6	b.2	b.2	X
admet-292	1478	7	)	)	PUNCT
admet-292	1478	8	the	the	DET
admet-292	1478	9	square	square	ADJ
admet-292	1478	10	brackets	bracket	NOUN
admet-292	1478	11	denote	denote	VERB
admet-292	1478	12	molar	molar	ADJ
admet-292	1478	13	concentration	concentration	NOUN
admet-292	1478	14	of	of	ADP
admet-292	1478	15	species	specie	NOUN
admet-292	1478	16	(	(	PUNCT
admet-292	1478	17	at	at	ADP
admet-292	1478	18	the	the	DET
admet-292	1478	19	constant	constant	ADJ
admet-292	1478	20	ionic	ionic	ADJ
admet-292	1478	21	medium	medium	ADJ
admet-292	1478	22	reference	reference	NOUN
admet-292	1478	23	state	state	NOUN
admet-292	1478	24	[	[	X
admet-292	1478	25	27	27	NUM
admet-292	1478	26	]	]	NUM
admet-292	1478	27	)	)	PUNCT
admet-292	1478	28	.	.	PUNCT
admet-292	1479	1	the	the	DET
admet-292	1479	2	above	above	ADJ
admet-292	1479	3	equation	equation	NOUN
admet-292	1479	4	is	be	AUX
admet-292	1479	5	usually	usually	ADV
admet-292	1479	6	converted	convert	VERB
admet-292	1479	7	into	into	ADP
admet-292	1479	8	an	an	DET
admet-292	1479	9	expression	expression	NOUN
admet-292	1479	10	containing	contain	VERB
admet-292	1479	11	only	only	ADJ
admet-292	1479	12	constants	constant	NOUN
admet-292	1479	13	and	and	CCONJ
admet-292	1479	14	[	[	X
admet-292	1479	15	h	h	NOUN
admet-292	1480	1	+	+	X
admet-292	1480	2	]	]	PUNCT
admet-292	1480	3	(	(	PUNCT
admet-292	1480	4	as	as	ADP
admet-292	1480	5	the	the	DET
admet-292	1480	6	sole	sole	ADJ
admet-292	1480	7	variable	variable	NOUN
admet-292	1480	8	)	)	PUNCT
admet-292	1480	9	,	,	PUNCT
admet-292	1480	10	by	by	ADP
admet-292	1480	11	substituting	substitute	VERB
admet-292	1480	12	the	the	DET
admet-292	1480	13	ionization	ionization	NOUN
admet-292	1480	14	and	and	CCONJ
admet-292	1480	15	solubility	solubility	NOUN
admet-292	1480	16	eqs	eqs	PROPN
admet-292	1480	17	.	.	PUNCT
admet-292	1480	18	b.1	b.1	PUNCT
admet-292	1480	19	into	into	ADP
admet-292	1480	20	eq	eq	NOUN
admet-292	1480	21	.	.	PUNCT
admet-292	1480	22	b.2	b.2	AUX
admet-292	1480	23	.	.	PUNCT
admet-292	1480	24	s	s	PART
admet-292	1480	25	=	=	PUNCT
admet-292	1481	1	[	[	X
admet-292	1481	2	h+][b	h+][b	X
admet-292	1481	3	]	]	X
admet-292	1481	4	/	/	SYM
admet-292	1481	5	ka	ka	PROPN
admet-292	1482	1	+	+	CCONJ
admet-292	1483	1	[	[	X
admet-292	1483	2	b	b	X
admet-292	1483	3	]	]	X
admet-292	1483	4	=	=	PUNCT
admet-292	1484	1	so	so	CCONJ
admet-292	1484	2	(	(	PUNCT
admet-292	1484	3	[	[	X
admet-292	1484	4	h+]/ka	h+]/ka	NOUN
admet-292	1484	5	+	+	CCONJ
admet-292	1484	6	1	1	NUM
admet-292	1484	7	)	)	PUNCT
admet-292	1484	8	=	=	SYM
admet-292	1484	9	s0	s0	NOUN
admet-292	1484	10	(	(	PUNCT
admet-292	1484	11	10	10	NUM
admet-292	1484	12	pka	pka	NOUN
admet-292	1484	13	ph	ph	NOUN
admet-292	1484	14	+	+	ADP
admet-292	1484	15	1	1	NUM
admet-292	1484	16	)	)	PUNCT
admet-292	1484	17	(	(	PUNCT
admet-292	1484	18	b.3	b.3	NOUN
admet-292	1484	19	)	)	PUNCT
admet-292	1484	20	logs	log	NOUN
admet-292	1484	21	=	=	SYM
admet-292	1484	22	logso	logso	NOUN
admet-292	1484	23	+	+	CCONJ
admet-292	1484	24	log(10+pka	log(10+pka	PROPN
admet-292	1484	25	ph	ph	NOUN
admet-292	1484	26	+	+	NOUN
admet-292	1484	27	1	1	NUM
admet-292	1484	28	)	)	PUNCT
admet-292	1484	29	(	(	PUNCT
admet-292	1484	30	b.4	b.4	NOUN
admet-292	1484	31	)	)	PUNCT
admet-292	1484	32	the	the	DET
admet-292	1484	33	dashed	dash	VERB
admet-292	1484	34	curve	curve	NOUN
admet-292	1484	35	in	in	ADP
admet-292	1484	36	figure	figure	NOUN
admet-292	1484	37	1a	1a	PROPN
admet-292	1484	38	is	be	AUX
admet-292	1484	39	a	a	DET
admet-292	1484	40	plot	plot	NOUN
admet-292	1484	41	of	of	ADP
admet-292	1484	42	eq	eq	PROPN
admet-292	1484	43	.	.	PROPN
admet-292	1484	44	b.4	b.4	PROPN
admet-292	1484	45	for	for	ADP
admet-292	1484	46	atenolol	atenolol	PROPN
admet-292	1484	47	(	(	PUNCT
admet-292	1484	48	pka	pka	PROPN
admet-292	1484	49	9.54	9.54	NUM
admet-292	1484	50	)	)	PUNCT
admet-292	1484	51	.	.	PUNCT
admet-292	1485	1	at	at	ADP
admet-292	1485	2	the	the	DET
admet-292	1485	3	bend	bend	NOUN
admet-292	1485	4	in	in	ADP
admet-292	1485	5	the	the	DET
admet-292	1485	6	curve	curve	NOUN
admet-292	1485	7	,	,	PUNCT
admet-292	1485	8	the	the	DET
admet-292	1485	9	ph	ph	NOUN
admet-292	1485	10	equals	equal	VERB
admet-292	1485	11	the	the	DET
admet-292	1485	12	pka	pka	PROPN
admet-292	1485	13	.	.	PUNCT
admet-292	1486	1	for	for	ADP
admet-292	1486	2	ph	ph	PROPN
admet-292	1486	3	>	>	PUNCT
admet-292	1486	4	>	>	X
admet-292	1486	5	pka	pka	PROPN
admet-292	1486	6	,	,	PUNCT
admet-292	1486	7	the	the	DET
admet-292	1486	8	equation	equation	NOUN
admet-292	1486	9	represents	represent	VERB
admet-292	1486	10	a	a	DET
admet-292	1486	11	horizontal	horizontal	ADJ
admet-292	1486	12	line	line	NOUN
admet-292	1486	13	:	:	PUNCT
admet-292	1486	14	logs	log	VERB
admet-292	1486	15			X
admet-292	1486	16	logso	logso	NOUN
admet-292	1486	17	;	;	PUNCT
admet-292	1486	18	for	for	ADP
admet-292	1486	19	ph	ph	NOUN
admet-292	1486	20	<	<	X
admet-292	1486	21	<	<	X
admet-292	1486	22	pka	pka	PROPN
admet-292	1486	23	,	,	PUNCT
admet-292	1486	24	the	the	DET
admet-292	1486	25	equation	equation	NOUN
admet-292	1486	26	is	be	AUX
admet-292	1486	27	a	a	DET
admet-292	1486	28	diagonal	diagonal	ADJ
admet-292	1486	29	line	line	NOUN
admet-292	1486	30	with	with	ADP
admet-292	1486	31	slope	slope	NOUN
admet-292	1486	32	-1	-1	NOUN
admet-292	1486	33	.	.	PUNCT
admet-292	1487	1	other	other	ADJ
admet-292	1487	2	cases	case	NOUN
admet-292	1487	3	may	may	AUX
admet-292	1487	4	be	be	AUX
admet-292	1487	5	similarly	similarly	ADV
admet-292	1487	6	derived	derive	VERB
admet-292	1487	7	.	.	PUNCT
admet-292	1488	1	table	table	NOUN
admet-292	1488	2	b.1	b.1	NOUN
admet-292	1488	3	is	be	AUX
admet-292	1488	4	a	a	DET
admet-292	1488	5	collection	collection	NOUN
admet-292	1488	6	of	of	ADP
admet-292	1488	7	solubility	solubility	NOUN
admet-292	1488	8	equations	equation	NOUN
admet-292	1488	9	for	for	ADP
admet-292	1488	10	such	such	ADJ
admet-292	1488	11	simple	simple	ADJ
admet-292	1488	12	cases	case	NOUN
admet-292	1488	13	,	,	PUNCT
admet-292	1488	14	with	with	ADP
admet-292	1488	15	up	up	ADP
admet-292	1488	16	to	to	PART
admet-292	1488	17	two	two	NUM
admet-292	1488	18	pka	pka	PROPN
admet-292	1488	19	values	value	NOUN
admet-292	1488	20	.	.	PUNCT
admet-292	1489	1	table	table	NOUN
admet-292	1489	2	b.1	b.1	NOUN
admet-292	1489	3	.	.	PUNCT
admet-292	1490	1	solubility	solubility	NOUN
admet-292	1490	2	-	-	PUNCT
admet-292	1490	3	ph	ph	NOUN
admet-292	1490	4	equations	equation	NOUN
admet-292	1490	5	for	for	ADP
admet-292	1490	6	monoand	monoand	ADJ
admet-292	1490	7	diprotic	diprotic	ADJ
admet-292	1490	8	molecules	molecule	NOUN
admet-292	1490	9	type	type	VERB
admet-292	1490	10	equilibrium	equilibrium	NOUN
admet-292	1490	11	intrinsic	intrinsic	ADJ
admet-292	1490	12	solubility	solubility	NOUN
admet-292	1490	13	equation	equation	NOUN
admet-292	1490	14	monoprotic	monoprotic	ADJ
admet-292	1490	15	acid	acid	NOUN
admet-292	1490	16	s0	s0	PROPN
admet-292	1490	17	ha(s	ha(	NOUN
admet-292	1490	18	)	)	PUNCT
admet-292	1490	19			X
admet-292	1490	20	ha	ha	INTJ
admet-292	1490	21	logs	logs	PROPN
admet-292	1490	22	=	=	PUNCT
admet-292	1490	23	logs0	logs0	NOUN
admet-292	1491	1	+	+	CCONJ
admet-292	1491	2	log{10	log{10	NOUN
admet-292	1491	3	–	–	PUNCT
admet-292	1491	4	pka	pka	NOUN
admet-292	1491	5	+	+	CCONJ
admet-292	1491	6	ph	ph	ADJ
admet-292	1491	7	+	+	CCONJ
admet-292	1491	8	1	1	NUM
admet-292	1491	9	}	}	PUNCT
admet-292	1491	10	diprotic	diprotic	ADJ
admet-292	1491	11	acid	acid	NOUN
admet-292	1491	12	s0	s0	PROPN
admet-292	1491	13	h2a(s	h2a(s	PROPN
admet-292	1491	14	)	)	PUNCT
admet-292	1491	15			X
admet-292	1491	16	h2a	h2a	X
admet-292	1491	17	logs	log	NOUN
admet-292	1491	18	=	=	SYM
admet-292	1491	19	logs0	logs0	NOUN
admet-292	1492	1	+	+	CCONJ
admet-292	1492	2	log{10	log{10	NOUN
admet-292	1492	3	–	–	PUNCT
admet-292	1492	4	pka1	pka1	PROPN
admet-292	1492	5	–	–	PUNCT
admet-292	1492	6	pka2	pka2	NOUN
admet-292	1492	7	+	+	CCONJ
admet-292	1492	8	2	2	NUM
admet-292	1492	9	ph	ph	NOUN
admet-292	1492	10	+	+	NUM
admet-292	1492	11	10	10	NUM
admet-292	1492	12	–	–	PUNCT
admet-292	1492	13	pka1	pka1	PROPN
admet-292	1492	14	+	+	CCONJ
admet-292	1492	15	ph	ph	ADJ
admet-292	1492	16	+	+	CCONJ
admet-292	1492	17	1	1	NUM
admet-292	1492	18	}	}	PUNCT
admet-292	1492	19	monoprotic	monoprotic	ADJ
admet-292	1492	20	base	base	NOUN
admet-292	1492	21	s0	s0	PROPN
admet-292	1492	22	b(s	b(s	PROPN
admet-292	1492	23	)	)	PUNCT
admet-292	1492	24			X
admet-292	1493	1	b	b	X
admet-292	1493	2	logs	log	NOUN
admet-292	1493	3	=	=	SYM
admet-292	1493	4	logs0	logs0	NOUN
admet-292	1494	1	+	+	CCONJ
admet-292	1494	2	log{10	log{10	X
admet-292	1494	3	+	+	X
admet-292	1494	4	pka	pka	X
admet-292	1494	5	–	–	PUNCT
admet-292	1494	6	ph	ph	ADJ
admet-292	1494	7	+	+	CCONJ
admet-292	1494	8	1	1	NUM
admet-292	1494	9	}	}	PUNCT
admet-292	1494	10	diprotic	diprotic	ADJ
admet-292	1494	11	base	base	NOUN
admet-292	1494	12	s0	s0	PROPN
admet-292	1494	13	b(s	b(s	PROPN
admet-292	1494	14	)	)	PUNCT
admet-292	1494	15			X
admet-292	1495	1	b	b	X
admet-292	1495	2	logs	log	NOUN
admet-292	1495	3	=	=	SYM
admet-292	1495	4	logs0	logs0	NOUN
admet-292	1496	1	+	+	CCONJ
admet-292	1496	2	log{10	log{10	X
admet-292	1496	3	+	+	ADJ
admet-292	1496	4	pka1	pka1	NOUN
admet-292	1496	5	+	+	CCONJ
admet-292	1496	6	pka2	pka2	NOUN
admet-292	1496	7	–	–	PUNCT
admet-292	1496	8	2	2	NUM
admet-292	1496	9	ph	ph	NOUN
admet-292	1496	10	+	+	CCONJ
admet-292	1496	11	10	10	NUM
admet-292	1496	12	+	+	ADJ
admet-292	1496	13	pka2	pka2	NOUN
admet-292	1496	14	–	–	PUNCT
admet-292	1496	15	ph	ph	ADJ
admet-292	1496	16	+	+	NOUN
admet-292	1496	17	1	1	NUM
admet-292	1496	18	}	}	PUNCT
admet-292	1496	19	diprotic	diprotic	ADJ
admet-292	1496	20	ampholyte	ampholyte	ADJ
admet-292	1496	21	s0	s0	PROPN
admet-292	1496	22	hx(s	hx(s	PROPN
admet-292	1496	23	)	)	PUNCT
admet-292	1496	24			PUNCT
admet-292	1497	1	hx	hx	PROPN
admet-292	1497	2	logs	log	VERB
admet-292	1497	3	=	=	SYM
admet-292	1497	4	logs0	logs0	NOUN
admet-292	1498	1	+	+	CCONJ
admet-292	1498	2	log{10	log{10	X
admet-292	1498	3	+	+	PRON
admet-292	1498	4	pka1	pka1	PROPN
admet-292	1498	5	–	–	PUNCT
admet-292	1498	6	ph	ph	ADJ
admet-292	1498	7	+	+	CCONJ
admet-292	1498	8	10	10	NUM
admet-292	1498	9	–	–	PUNCT
admet-292	1498	10	pka2	pka2	NOUN
admet-292	1498	11	+	+	CCONJ
admet-292	1498	12	ph	ph	ADJ
admet-292	1498	13	+	+	CCONJ
admet-292	1498	14	1	1	NUM
admet-292	1498	15	}	}	PUNCT
admet-292	1498	16	admet	admet	PROPN
admet-292	1498	17	&	&	CCONJ
admet-292	1498	18	dmpk	dmpk	PROPN
admet-292	1498	19	4(2	4(2	NUM
admet-292	1498	20	)	)	PUNCT
admet-292	1498	21	(	(	PUNCT
admet-292	1498	22	2016	2016	NUM
admet-292	1498	23	)	)	PUNCT
admet-292	1498	24	117	117	NUM
admet-292	1498	25	-	-	SYM
admet-292	1498	26	178	178	NUM
admet-292	1498	27	consensus	consensus	NOUN
admet-292	1498	28	recommendations	recommendation	NOUN
admet-292	1498	29	for	for	ADP
admet-292	1498	30	improving	improve	VERB
admet-292	1498	31	solubility	solubility	NOUN
admet-292	1498	32	-	-	PUNCT
admet-292	1498	33	ph	ph	ADJ
admet-292	1498	34	data	datum	NOUN
admet-292	1498	35	quality	quality	NOUN
admet-292	1498	36	doi	doi	NOUN
admet-292	1498	37	:	:	PUNCT
admet-292	1498	38	10.5599	10.5599	NUM
admet-292	1498	39	/	/	SYM
admet-292	1498	40	admet.4.2.292	admet.4.2.292	NUM
admet-292	1498	41	167	167	NUM
admet-292	1498	42	appendix	appendix	NOUN
admet-292	1498	43	c	c	NOUN
admet-292	1498	44	–	–	PUNCT
admet-292	1498	45	the	the	DET
admet-292	1498	46	four	four	NUM
admet-292	1498	47	-	-	PUNCT
admet-292	1498	48	parameter	parameter	NOUN
admet-292	1498	49	electrode	electrode	NOUN
admet-292	1498	50	calibration	calibration	NOUN
admet-292	1498	51	procedure	procedure	NOUN
admet-292	1498	52	in	in	ADP
admet-292	1498	53	highly	highly	ADV
admet-292	1498	54	-	-	PUNCT
admet-292	1498	55	developed	develop	VERB
admet-292	1498	56	potentiometric	potentiometric	ADJ
admet-292	1498	57	methods	method	NOUN
admet-292	1498	58	for	for	ADP
admet-292	1498	59	pka	pka	PROPN
admet-292	1498	60	determination	determination	NOUN
admet-292	1498	61	,	,	PUNCT
admet-292	1498	62	research	research	NOUN
admet-292	1498	63	-	-	PUNCT
admet-292	1498	64	grade	grade	NOUN
admet-292	1498	65	combination	combination	NOUN
admet-292	1498	66	ph	ph	NOUN
admet-292	1498	67	electrodes	electrode	NOUN
admet-292	1498	68	are	be	AUX
admet-292	1498	69	calibrated	calibrate	VERB
admet-292	1498	70	to	to	PART
admet-292	1498	71	cope	cope	VERB
admet-292	1498	72	with	with	ADP
admet-292	1498	73	large	large	ADJ
admet-292	1498	74	swings	swing	NOUN
admet-292	1498	75	in	in	ADP
admet-292	1498	76	ionic	ionic	ADJ
admet-292	1498	77	strength	strength	NOUN
admet-292	1498	78	,	,	PUNCT
admet-292	1498	79	over	over	ADP
admet-292	1498	80	a	a	DET
admet-292	1498	81	wide	wide	ADJ
admet-292	1498	82	range	range	NOUN
admet-292	1498	83	of	of	ADP
admet-292	1498	84	ph	ph	ADJ
admet-292	1498	85	0.5	0.5	NUM
admet-292	1498	86	-	-	SYM
admet-292	1498	87	13.5	13.5	NUM
admet-292	1499	1	[	[	X
admet-292	1499	2	27	27	NUM
admet-292	1499	3	]	]	PUNCT
admet-292	1499	4	.	.	PUNCT
admet-292	1500	1	some	some	PRON
admet-292	1500	2	of	of	ADP
admet-292	1500	3	the	the	DET
admet-292	1500	4	calibration	calibration	NOUN
admet-292	1500	5	procedures	procedure	NOUN
admet-292	1500	6	can	can	AUX
admet-292	1500	7	be	be	AUX
admet-292	1500	8	translated	translate	VERB
admet-292	1500	9	to	to	ADP
admet-292	1500	10	ph	ph	ADJ
admet-292	1500	11	reading	reading	NOUN
admet-292	1500	12	in	in	ADP
admet-292	1500	13	solubility	solubility	NOUN
admet-292	1500	14	–	–	PUNCT
admet-292	1500	15	ph	ph	ADJ
admet-292	1500	16	experiments	experiment	NOUN
admet-292	1500	17	.	.	PUNCT
admet-292	1501	1	the	the	DET
admet-292	1501	2	voltage	voltage	NOUN
admet-292	1501	3	read	read	VERB
admet-292	1501	4	by	by	ADP
admet-292	1501	5	a	a	DET
admet-292	1501	6	ph	ph	ADJ
admet-292	1501	7	meter	meter	NOUN
admet-292	1501	8	needs	need	VERB
admet-292	1501	9	to	to	PART
admet-292	1501	10	be	be	AUX
admet-292	1501	11	converted	convert	VERB
admet-292	1501	12	to	to	ADP
admet-292	1501	13	‘	'	PUNCT
admet-292	1501	14	ph	ph	NOUN
admet-292	1501	15	’	'	PUNCT
admet-292	1501	16	on	on	ADP
admet-292	1501	17	what	what	PRON
admet-292	1501	18	is	be	AUX
admet-292	1501	19	called	call	VERB
admet-292	1501	20	the	the	DET
admet-292	1501	21	operational	operational	ADJ
admet-292	1501	22	scale	scale	NOUN
admet-292	1501	23	.	.	PUNCT
admet-292	1502	1	in	in	ADP
admet-292	1502	2	the	the	DET
admet-292	1502	3	two	two	NUM
admet-292	1502	4	-	-	PUNCT
admet-292	1502	5	part	part	NOUN
admet-292	1502	6	procedures	procedure	NOUN
admet-292	1502	7	of	of	ADP
admet-292	1502	8	the	the	DET
admet-292	1502	9	pion	pion	PROPN
admet-292	1502	10	inc	inc	PROPN
admet-292	1502	11	and	and	CCONJ
admet-292	1502	12	sirius	sirius	PROPN
admet-292	1502	13	analytical	analytical	PROPN
admet-292	1502	14	ltd	ltd	PROPN
admet-292	1503	1	pka	pka	PROPN
admet-292	1503	2	analyzers	analyzer	NOUN
admet-292	1503	3	,	,	PUNCT
admet-292	1503	4	the	the	DET
admet-292	1503	5	ph	ph	ADJ
admet-292	1503	6	electrode	electrode	NOUN
admet-292	1503	7	is	be	AUX
admet-292	1503	8	first	first	ADV
admet-292	1503	9	‘	'	PUNCT
admet-292	1503	10	calibrated	calibrate	VERB
admet-292	1503	11	’	'	PUNCT
admet-292	1503	12	before	before	SCONJ
admet-292	1503	13	each	each	PRON
admet-292	1503	14	assay	assay	VERB
admet-292	1503	15	with	with	ADP
admet-292	1503	16	a	a	DET
admet-292	1503	17	single	single	ADJ
admet-292	1503	18	aqueous	aqueous	ADJ
admet-292	1503	19	ph	ph	NOUN
admet-292	1503	20	7.00	7.00	NUM
admet-292	1503	21	buffer(traceable	buffer(traceable	ADJ
admet-292	1503	22	to	to	ADP
admet-292	1503	23	the	the	DET
admet-292	1503	24	nist	nist	NOUN
admet-292	1503	25	phosphate	phosphate	NOUN
admet-292	1503	26	buffer	buffer	NOUN
admet-292	1503	27	at	at	ADP
admet-292	1503	28	25	25	NUM
admet-292	1503	29	°	°	NOUN
admet-292	1503	30	c	c	NOUN
admet-292	1503	31	,	,	PUNCT
admet-292	1503	32	ph	ph	VERB
admet-292	1503	33	6.865	6.865	NUM
admet-292	1503	34	[	[	NOUN
admet-292	1503	35	155	155	NUM
admet-292	1503	36	]	]	PUNCT
admet-292	1503	37	)	)	PUNCT
admet-292	1503	38	,	,	PUNCT
admet-292	1503	39	with	with	SCONJ
admet-292	1503	40	the	the	DET
admet-292	1503	41	ideal	ideal	ADJ
admet-292	1503	42	nernst	nernst	PROPN
admet-292	1503	43	slope	slope	PROPN
admet-292	1503	44	assumed	assume	VERB
admet-292	1503	45	to	to	PART
admet-292	1503	46	be	be	AUX
admet-292	1503	47	59.16	59.16	NUM
admet-292	1503	48	mv	mv	PROPN
admet-292	1503	49	/	/	SYM
admet-292	1503	50	ph	ph	NOUN
admet-292	1503	51	(	(	PUNCT
admet-292	1503	52	25	25	NUM
admet-292	1503	53	°	°	NOUN
admet-292	1503	54	c	c	NOUN
admet-292	1503	55	)	)	PUNCT
admet-292	1503	56	.	.	PUNCT
admet-292	1504	1	then	then	ADV
admet-292	1504	2	this	this	DET
admet-292	1504	3	operational	operational	ADJ
admet-292	1504	4	ph	ph	NOUN
admet-292	1504	5	is	be	AUX
admet-292	1504	6	‘	'	PUNCT
admet-292	1504	7	standardized	standardize	VERB
admet-292	1504	8	’	'	PUNCT
admet-292	1504	9	to	to	ADP
admet-292	1504	10	a	a	DET
admet-292	1504	11	concentration	concentration	NOUN
admet-292	1504	12	-	-	PUNCT
admet-292	1504	13	based	base	VERB
admet-292	1504	14	pch	pch	ADJ
admet-292	1504	15	scale	scale	NOUN
admet-292	1504	16	(	(	PUNCT
admet-292	1504	17	i.e.	i.e.	X
admet-292	1504	18	,	,	PUNCT
admet-292	1504	19	-log[h	-log[h	PUNCT
admet-292	1505	1	+	+	X
admet-292	1505	2	]	]	X
admet-292	1505	3	)	)	PUNCT
admet-292	1505	4	,	,	PUNCT
admet-292	1505	5	done	do	VERB
admet-292	1505	6	on	on	ADP
admet-292	1505	7	a	a	DET
admet-292	1505	8	weekly	weekly	ADJ
admet-292	1505	9	basis	basis	NOUN
admet-292	1505	10	.	.	PUNCT
admet-292	1506	1	both	both	DET
admet-292	1506	2	steps	step	NOUN
admet-292	1506	3	are	be	AUX
admet-292	1506	4	carried	carry	VERB
admet-292	1506	5	out	out	ADP
admet-292	1506	6	under	under	ADP
admet-292	1506	7	thermostated	thermostat	VERB
admet-292	1506	8	conditions	condition	NOUN
admet-292	1506	9	(	(	PUNCT
admet-292	1506	10	most	most	ADV
admet-292	1506	11	commonly	commonly	ADV
admet-292	1506	12	at	at	ADP
admet-292	1506	13	25	25	NUM
admet-292	1506	14	±	±	NUM
admet-292	1506	15	0.1	0.1	NUM
admet-292	1506	16	°	°	ADP
admet-292	1506	17	c	c	NOUN
admet-292	1506	18	)	)	PUNCT
admet-292	1506	19	.	.	PUNCT
admet-292	1507	1	equilibrium	equilibrium	NOUN
admet-292	1507	2	quotients	quotient	VERB
admet-292	1507	3	in	in	ADP
admet-292	1507	4	currently	currently	ADV
admet-292	1507	5	practiced	practice	VERB
admet-292	1507	6	pka	pka	PROPN
admet-292	1507	7	and	and	CCONJ
admet-292	1507	8	solubility	solubility	NOUN
admet-292	1507	9	procedures	procedure	NOUN
admet-292	1507	10	employ	employ	VERB
admet-292	1507	11	the	the	DET
admet-292	1507	12	constant	constant	ADJ
admet-292	1507	13	ionic	ionic	ADJ
admet-292	1507	14	medium	medium	ADJ
admet-292	1507	15	activity	activity	NOUN
admet-292	1507	16	scale	scale	NOUN
admet-292	1507	17	where	where	SCONJ
admet-292	1507	18	pch	pch	ADJ
admet-292	1507	19	rather	rather	ADV
admet-292	1507	20	than	than	ADP
admet-292	1507	21	ph	ph	NOUN
admet-292	1507	22	is	be	AUX
admet-292	1507	23	applied	apply	VERB
admet-292	1507	24	.	.	PUNCT
admet-292	1508	1	this	this	PRON
admet-292	1508	2	is	be	AUX
admet-292	1508	3	a	a	DET
admet-292	1508	4	valid	valid	ADJ
admet-292	1508	5	thermodynamic	thermodynamic	ADJ
admet-292	1508	6	activity	activity	NOUN
admet-292	1508	7	scale	scale	NOUN
admet-292	1508	8	,	,	PUNCT
admet-292	1508	9	where	where	SCONJ
admet-292	1508	10	the	the	DET
admet-292	1508	11	limiting	limit	VERB
admet-292	1508	12	state	state	NOUN
admet-292	1508	13	is	be	AUX
admet-292	1508	14	the	the	DET
admet-292	1508	15	ionic	ionic	ADJ
admet-292	1508	16	strength	strength	NOUN
admet-292	1508	17	-	-	PUNCT
admet-292	1508	18	adjusted	adjust	VERB
admet-292	1508	19	solution	solution	NOUN
admet-292	1508	20	(	(	PUNCT
admet-292	1508	21	e.g.	e.g.	ADV
admet-292	1508	22	,	,	PUNCT
admet-292	1508	23	0.15	0.15	NUM
admet-292	1508	24	m	m	NOUN
admet-292	1508	25	kcl	kcl	NOUN
admet-292	1508	26	)	)	PUNCT
admet-292	1508	27	,	,	PUNCT
admet-292	1508	28	rather	rather	ADV
admet-292	1508	29	than	than	ADP
admet-292	1508	30	pure	pure	ADJ
admet-292	1508	31	water	water	NOUN
admet-292	1508	32	.	.	PUNCT
admet-292	1509	1	for	for	ADP
admet-292	1509	2	many	many	ADJ
admet-292	1509	3	years	year	NOUN
admet-292	1509	4	,	,	PUNCT
admet-292	1509	5	the	the	DET
admet-292	1509	6	ph	ph	NOUN
admet-292	1509	7	–	–	PUNCT
admet-292	1509	8	to	to	PART
admet-292	1509	9	–	–	PUNCT
admet-292	1509	10	pch	pch	ADJ
admet-292	1509	11	standardization	standardization	NOUN
admet-292	1509	12	has	have	AUX
admet-292	1509	13	been	be	AUX
admet-292	1509	14	based	base	VERB
admet-292	1509	15	on	on	ADP
admet-292	1509	16	the	the	DET
admet-292	1509	17	equation	equation	NOUN
admet-292	1509	18	below	below	ADP
admet-292	1509	19	[	[	X
admet-292	1509	20	27	27	NUM
admet-292	1509	21	,	,	PUNCT
admet-292	1509	22	45	45	NUM
admet-292	1509	23	,	,	PUNCT
admet-292	1509	24	111	111	NUM
admet-292	1509	25	-	-	SYM
admet-292	1509	26	113	113	NUM
admet-292	1509	27	]	]	PUNCT
admet-292	1509	28	,	,	PUNCT
admet-292	1509	29	ph	ph	NOUN
admet-292	1509	30	=	=	SYM
admet-292	1509	31	α	α	PROPN
admet-292	1509	32	+	+	X
admet-292	1509	33	ks	ks	PROPN
admet-292	1509	34	∙	∙	PROPN
admet-292	1509	35	pch	pch	PROPN
admet-292	1510	1	+	+	PROPN
admet-292	1510	2	jh	jh	PROPN
admet-292	1510	3	∙	∙	PROPN
admet-292	1510	4	[	[	X
admet-292	1510	5	h+	h+	X
admet-292	1510	6	]	]	X
admet-292	1510	7	+	+	CCONJ
admet-292	1510	8	joh	joh	PROPN
admet-292	1510	9	∙	∙	PROPN
admet-292	1510	10	kw/[h+	kw/[h+	PROPN
admet-292	1510	11	]	]	X
admet-292	1510	12	(	(	PUNCT
admet-292	1510	13	c.1	c.1	NOUN
admet-292	1510	14	)	)	PUNCT
admet-292	1510	15	where	where	SCONJ
admet-292	1510	16	kw	kw	PROPN
admet-292	1510	17	is	be	AUX
admet-292	1510	18	the	the	DET
admet-292	1510	19	ionization	ionization	NOUN
admet-292	1510	20	constant	constant	ADJ
admet-292	1510	21	of	of	ADP
admet-292	1510	22	water	water	NOUN
admet-292	1510	23	,	,	PUNCT
admet-292	1510	24	kw	kw	NOUN
admet-292	1510	25	=	=	PUNCT
admet-292	1511	1	[	[	X
admet-292	1511	2	h	h	NOUN
admet-292	1512	1	+	+	X
admet-292	1512	2	]	]	PUNCT
admet-292	1513	1	[	[	X
admet-292	1513	2	oh	oh	INTJ
admet-292	1513	3	–	–	PUNCT
admet-292	1513	4	]	]	PUNCT
admet-292	1513	5	(	(	PUNCT
admet-292	1513	6	concentration	concentration	NOUN
admet-292	1513	7	scale	scale	NOUN
admet-292	1513	8	,	,	PUNCT
admet-292	1513	9	molarity	molarity	NOUN
admet-292	1513	10	)	)	PUNCT
admet-292	1513	11	.	.	PUNCT
admet-292	1514	1	at	at	ADP
admet-292	1514	2	25	25	NUM
admet-292	1514	3	°	°	NOUN
admet-292	1514	4	c	c	NOUN
admet-292	1514	5	and	and	CCONJ
admet-292	1514	6	0.15	0.15	NUM
admet-292	1514	7	m	m	NOUN
admet-292	1514	8	ionic	ionic	ADJ
admet-292	1514	9	strength	strength	NOUN
admet-292	1514	10	,	,	PUNCT
admet-292	1514	11	pkw	pkw	PROPN
admet-292	1514	12	=	=	PROPN
admet-292	1514	13	13.764	13.764	NUM
admet-292	1514	14	.	.	PUNCT
admet-292	1515	1	the	the	DET
admet-292	1515	2	four	four	NUM
admet-292	1515	3	parameters	parameter	NOUN
admet-292	1515	4	(	(	PUNCT
admet-292	1515	5	α	α	NOUN
admet-292	1515	6	,	,	PUNCT
admet-292	1515	7	ks	ks	PROPN
admet-292	1515	8	,	,	PUNCT
admet-292	1515	9	jh	jh	PROPN
admet-292	1515	10	,	,	PUNCT
admet-292	1515	11	joh	joh	PROPN
admet-292	1515	12	)	)	PUNCT
admet-292	1515	13	are	be	AUX
admet-292	1515	14	determined	determine	VERB
admet-292	1515	15	by	by	ADP
admet-292	1515	16	a	a	DET
admet-292	1515	17	weighted	weight	VERB
admet-292	1515	18	least	least	ADJ
admet-292	1515	19	-	-	PUNCT
admet-292	1515	20	squares	square	NOUN
admet-292	1515	21	procedure	procedure	NOUN
admet-292	1515	22	using	use	VERB
admet-292	1515	23	data	datum	NOUN
admet-292	1515	24	from	from	ADP
admet-292	1515	25	alkalimetric	alkalimetric	ADJ
admet-292	1515	26	“	"	PUNCT
admet-292	1515	27	blank	blank	ADJ
admet-292	1515	28	”	"	PUNCT
admet-292	1515	29	titrations	titration	NOUN
admet-292	1515	30	of	of	ADP
admet-292	1515	31	known	know	VERB
admet-292	1515	32	concentrations	concentration	NOUN
admet-292	1515	33	of	of	ADP
admet-292	1515	34	hcl	hcl	PROPN
admet-292	1515	35	[	[	X
admet-292	1515	36	45	45	NUM
admet-292	1515	37	]	]	PUNCT
admet-292	1515	38	.	.	PUNCT
admet-292	1516	1	typical	typical	ADJ
admet-292	1516	2	aqueous	aqueous	ADJ
admet-292	1516	3	values	value	NOUN
admet-292	1516	4	of	of	ADP
admet-292	1516	5	the	the	DET
admet-292	1516	6	adjustable	adjustable	ADJ
admet-292	1516	7	parameters	parameter	NOUN
admet-292	1516	8	are	be	AUX
admet-292	1516	9	shown	show	VERB
admet-292	1516	10	in	in	ADP
admet-292	1516	11	table	table	NOUN
admet-292	1516	12	c.1	c.1	NOUN
admet-292	1516	13	.	.	PUNCT
admet-292	1517	1	such	such	DET
admet-292	1517	2	a	a	DET
admet-292	1517	3	standardization	standardization	NOUN
admet-292	1517	4	scheme	scheme	NOUN
admet-292	1517	5	extends	extend	VERB
admet-292	1517	6	the	the	DET
admet-292	1517	7	range	range	NOUN
admet-292	1517	8	of	of	ADP
admet-292	1517	9	accurate	accurate	ADJ
admet-292	1517	10	ph	ph	ADJ
admet-292	1517	11	measurements	measurement	NOUN
admet-292	1517	12	and	and	CCONJ
admet-292	1517	13	allows	allow	VERB
admet-292	1517	14	pka	pka	PROPN
admet-292	1517	15	values	value	NOUN
admet-292	1517	16	to	to	PART
admet-292	1517	17	be	be	AUX
admet-292	1517	18	assessed	assess	VERB
admet-292	1517	19	as	as	ADV
admet-292	1517	20	low	low	ADJ
admet-292	1517	21	as	as	ADP
admet-292	1517	22	0.6	0.6	NUM
admet-292	1517	23	(	(	PUNCT
admet-292	1517	24	caffeine	caffeine	NOUN
admet-292	1517	25	)	)	PUNCT
admet-292	1517	26	and	and	CCONJ
admet-292	1517	27	as	as	ADV
admet-292	1517	28	high	high	ADJ
admet-292	1517	29	as	as	ADP
admet-292	1517	30	13.3	13.3	NUM
admet-292	1517	31	(	(	PUNCT
admet-292	1517	32	salicylic	salicylic	ADJ
admet-292	1517	33	acid	acid	NOUN
admet-292	1517	34	)	)	PUNCT
admet-292	1518	1	[	[	X
admet-292	1518	2	27	27	NUM
admet-292	1518	3	]	]	PUNCT
admet-292	1518	4	.	.	PUNCT
admet-292	1519	1	table	table	NOUN
admet-292	1519	2	c.1	c.1	NOUN
admet-292	1519	3	typical	typical	ADJ
admet-292	1519	4	four	four	NUM
admet-292	1519	5	parameter	parameter	NOUN
admet-292	1519	6	electrode	electrode	NOUN
admet-292	1519	7	standardization	standardization	NOUN
admet-292	1519	8	parameters	parameter	NOUN
admet-292	1519	9	a	a	DET
admet-292	1519	10	temperature	temperature	NOUN
admet-292	1519	11	(	(	PUNCT
admet-292	1519	12	°	°	ADP
admet-292	1519	13	c	c	NOUN
admet-292	1519	14	)	)	PUNCT
admet-292	1519	15	ionic	ionic	ADJ
admet-292	1519	16	strength	strength	NOUN
admet-292	1519	17	(	(	PUNCT
admet-292	1519	18	m	m	NOUN
admet-292	1519	19	)	)	PUNCT
admet-292	1520	1	α	α	PROPN
admet-292	1520	2	ks	ks	PROPN
admet-292	1520	3	jh	jh	PROPN
admet-292	1520	4	joh	joh	PROPN
admet-292	1520	5	25	25	NUM
admet-292	1520	6	0.00	0.00	NUM
admet-292	1520	7	0.070	0.070	NUM
admet-292	1520	8	0.9971	0.9971	NUM
admet-292	1520	9	0.8	0.8	NUM
admet-292	1520	10	-0.6	-0.6	NOUN
admet-292	1520	11	25	25	NUM
admet-292	1520	12	0.15	0.15	NUM
admet-292	1520	13	0.090	0.090	NUM
admet-292	1520	14	1.0019	1.0019	NUM
admet-292	1520	15	0.5	0.5	NUM
admet-292	1520	16	-0.5	-0.5	NUM
admet-292	1520	17	25	25	NUM
admet-292	1520	18	1.00	1.00	NUM
admet-292	1520	19	0.109	0.109	NUM
admet-292	1521	1	0.9935	0.9935	NUM
admet-292	1521	2	-1.2	-1.2	NOUN
admet-292	1521	3	0.0	0.0	NUM
admet-292	1521	4	37	37	NUM
admet-292	1521	5	0.00	0.00	NUM
admet-292	1521	6	0.070	0.070	NUM
admet-292	1521	7	0.9972	0.9972	NUM
admet-292	1521	8	0.3	0.3	NUM
admet-292	1521	9	-0.8	-0.8	NUM
admet-292	1521	10	37	37	NUM
admet-292	1521	11	0.15	0.15	NUM
admet-292	1521	12	0.091	0.091	NUM
admet-292	1521	13	1.0017	1.0017	NUM
admet-292	1521	14	0.0	0.0	NUM
admet-292	1521	15	-0.7	-0.7	PROPN
admet-292	1521	16	37	37	NUM
admet-292	1521	17	1.00	1.00	NUM
admet-292	1521	18	0.109	0.109	NUM
admet-292	1521	19	0.9933	0.9933	NUM
admet-292	1521	20	-2.7	-2.7	NOUN
admet-292	1521	21	0.2	0.2	NUM
admet-292	1521	22	a	a	DET
admet-292	1521	23	each	each	DET
admet-292	1521	24	ph	ph	ADJ
admet-292	1521	25	electrode	electrode	NOUN
admet-292	1521	26	may	may	AUX
admet-292	1521	27	have	have	VERB
admet-292	1521	28	its	its	PRON
admet-292	1521	29	own	own	ADJ
admet-292	1521	30	distinct	distinct	ADJ
admet-292	1521	31	parameters	parameter	NOUN
admet-292	1521	32	,	,	PUNCT
admet-292	1521	33	which	which	PRON
admet-292	1521	34	need	need	VERB
admet-292	1521	35	to	to	PART
admet-292	1521	36	be	be	AUX
admet-292	1521	37	checked	check	VERB
admet-292	1521	38	on	on	ADP
admet-292	1521	39	a	a	DET
admet-292	1521	40	weekly	weekly	ADJ
admet-292	1521	41	basis	basis	NOUN
admet-292	1521	42	during	during	ADP
admet-292	1521	43	periods	period	NOUN
admet-292	1521	44	of	of	ADP
admet-292	1521	45	active	active	ADJ
admet-292	1521	46	use	use	NOUN
admet-292	1521	47	[	[	X
admet-292	1521	48	27	27	NUM
admet-292	1521	49	]	]	PUNCT
admet-292	1521	50	.	.	PUNCT
admet-292	1522	1	the	the	DET
admet-292	1522	2	intercept	intercept	NOUN
admet-292	1522	3	constant	constant	ADJ
admet-292	1522	4	,	,	PUNCT
admet-292	1522	5	α	α	X
admet-292	1522	6	,	,	PUNCT
admet-292	1522	7	is	be	AUX
admet-292	1522	8	ideally	ideally	ADV
admet-292	1522	9	defined	define	VERB
admet-292	1522	10	by	by	ADP
admet-292	1522	11	-logfh	-logfh	PROPN
admet-292	1522	12	,	,	PUNCT
admet-292	1522	13	where	where	SCONJ
admet-292	1522	14	fh	fh	PROPN
admet-292	1522	15	is	be	AUX
admet-292	1522	16	the	the	DET
admet-292	1522	17	activity	activity	NOUN
admet-292	1522	18	coefficient	coefficient	NOUN
admet-292	1522	19	of	of	ADP
admet-292	1522	20	the	the	DET
admet-292	1522	21	h+	h+	X
admet-292	1522	22	(	(	PUNCT
admet-292	1522	23	i.e.	i.e.	X
admet-292	1522	24	,	,	PUNCT
admet-292	1522	25	activity	activity	NOUN
admet-292	1522	26	of	of	ADP
admet-292	1522	27	h+	h+	PROPN
admet-292	1522	28	,	,	PUNCT
admet-292	1522	29	{	{	PUNCT
admet-292	1522	30	h+	h+	X
admet-292	1522	31	}	}	PUNCT
admet-292	1522	32	=	=	SYM
admet-292	1522	33	0.81	0.81	NUM
admet-292	1522	34	[	[	X
admet-292	1522	35	h+	h+	X
admet-292	1522	36	]	]	X
admet-292	1522	37	)	)	PUNCT
admet-292	1522	38	.	.	PUNCT
admet-292	1523	1	in	in	ADP
admet-292	1523	2	practice	practice	NOUN
admet-292	1523	3	,	,	PUNCT
admet-292	1523	4	α	α	PRON
admet-292	1523	5	may	may	AUX
admet-292	1523	6	also	also	ADV
admet-292	1523	7	serve	serve	VERB
admet-292	1523	8	to	to	PART
admet-292	1523	9	mop	mop	VERB
admet-292	1523	10	up	up	ADP
admet-292	1523	11	other	other	ADJ
admet-292	1523	12	effects	effect	NOUN
admet-292	1523	13	not	not	PART
admet-292	1523	14	dependent	dependent	ADJ
admet-292	1523	15	on	on	ADP
admet-292	1523	16	ph	ph	PROPN
admet-292	1523	17	.	.	PUNCT
admet-292	1524	1	the	the	DET
admet-292	1524	2	slope	slope	NOUN
admet-292	1524	3	factor	factor	NOUN
admet-292	1524	4	,	,	PUNCT
admet-292	1524	5	ks	ks	NOUN
admet-292	1524	6	,	,	PUNCT
admet-292	1524	7	is	be	AUX
admet-292	1524	8	used	use	VERB
admet-292	1524	9	to	to	PART
admet-292	1524	10	take	take	VERB
admet-292	1524	11	into	into	ADP
admet-292	1524	12	account	account	NOUN
admet-292	1524	13	that	that	SCONJ
admet-292	1524	14	a	a	DET
admet-292	1524	15	particular	particular	ADJ
admet-292	1524	16	ph	ph	NOUN
admet-292	1524	17	electrode	electrode	NOUN
admet-292	1524	18	may	may	AUX
admet-292	1524	19	not	not	PART
admet-292	1524	20	have	have	VERB
admet-292	1524	21	the	the	DET
admet-292	1524	22	ideal	ideal	ADJ
admet-292	1524	23	100	100	NUM
admet-292	1524	24	%	%	NOUN
admet-292	1524	25	nernstian	nernstian	ADJ
admet-292	1524	26	slope	slope	NOUN
admet-292	1524	27	.	.	PUNCT
admet-292	1525	1	liquid	liquid	ADJ
admet-292	1525	2	junction	junction	NOUN
admet-292	1525	3	potentials	potential	VERB
admet-292	1525	4	that	that	SCONJ
admet-292	1525	5	form	form	VERB
admet-292	1525	6	in	in	ADP
admet-292	1525	7	very	very	ADV
admet-292	1525	8	low	low	ADJ
admet-292	1525	9	ionic	ionic	ADJ
admet-292	1525	10	strength	strength	NOUN
admet-292	1525	11	solutions	solution	NOUN
admet-292	1525	12	can	can	AUX
admet-292	1525	13	be	be	AUX
admet-292	1525	14	slightly	slightly	ADV
admet-292	1525	15	ph	ph	ADJ
admet-292	1525	16	-	-	ADJ
admet-292	1525	17	dependent	dependent	ADJ
admet-292	1525	18	,	,	PUNCT
admet-292	1525	19	an	an	DET
admet-292	1525	20	effect	effect	NOUN
admet-292	1525	21	that	that	PRON
admet-292	1525	22	propagates	propagate	VERB
admet-292	1525	23	into	into	ADP
admet-292	1525	24	the	the	DET
admet-292	1525	25	ks	ks	PROPN
admet-292	1525	26	empirical	empirical	ADJ
admet-292	1525	27	slope	slope	NOUN
admet-292	1525	28	factor	factor	NOUN
admet-292	1525	29	parameter	parameter	NOUN
admet-292	1525	30	[	[	X
admet-292	1525	31	27	27	NUM
admet-292	1525	32	]	]	PUNCT
admet-292	1525	33	.	.	PUNCT
admet-292	1526	1	the	the	DET
admet-292	1526	2	jh	jh	PROPN
admet-292	1526	3	term	term	NOUN
admet-292	1526	4	corrects	correct	VERB
admet-292	1526	5	ph	ph	ADJ
admet-292	1526	6	readings	reading	NOUN
admet-292	1526	7	for	for	ADP
admet-292	1526	8	the	the	DET
admet-292	1526	9	nonlinear	nonlinear	ADJ
admet-292	1526	10	ph	ph	ADJ
admet-292	1526	11	response	response	NOUN
admet-292	1526	12	due	due	ADP
admet-292	1526	13	to	to	ADP
admet-292	1526	14	the	the	DET
admet-292	1526	15	liquid	liquid	ADJ
admet-292	1526	16	junction	junction	NOUN
admet-292	1526	17	and	and	CCONJ
admet-292	1526	18	asymmetry	asymmetry	NOUN
admet-292	1526	19	potentials	potential	NOUN
admet-292	1526	20	in	in	ADP
admet-292	1526	21	acidic	acidic	ADJ
admet-292	1526	22	alex	alex	PROPN
admet-292	1526	23	avdeef	avdeef	PROPN
admet-292	1526	24	et	et	PROPN
admet-292	1526	25	al	al	PROPN
admet-292	1526	26	.	.	PROPN
admet-292	1526	27	admet	admet	PROPN
admet-292	1526	28	&	&	CCONJ
admet-292	1526	29	dmpk	dmpk	PROPN
admet-292	1526	30	4(2	4(2	NUM
admet-292	1526	31	)	)	PUNCT
admet-292	1526	32	(	(	PUNCT
admet-292	1526	33	2016	2016	NUM
admet-292	1526	34	)	)	PUNCT
admet-292	1526	35	117	117	NUM
admet-292	1526	36	-	-	SYM
admet-292	1526	37	178	178	NUM
admet-292	1526	38	168	168	NUM
admet-292	1526	39	solutions	solution	NOUN
admet-292	1526	40	(	(	PUNCT
admet-292	1526	41	ph<2.5	ph<2.5	PROPN
admet-292	1526	42	)	)	PUNCT
admet-292	1526	43	.	.	PUNCT
admet-292	1527	1	the	the	DET
admet-292	1527	2	joh	joh	PROPN
admet-292	1527	3	term	term	NOUN
admet-292	1527	4	corrects	correct	NOUN
admet-292	1527	5	for	for	ADP
admet-292	1527	6	alkaline	alkaline	NOUN
admet-292	1527	7	(	(	PUNCT
admet-292	1527	8	ph>11.5	ph>11.5	NOUN
admet-292	1527	9	)	)	PUNCT
admet-292	1527	10	nonlinear	nonlinear	ADJ
admet-292	1527	11	effects	effect	NOUN
admet-292	1527	12	,	,	PUNCT
admet-292	1527	13	due	due	ADP
admet-292	1527	14	to	to	ADP
admet-292	1527	15	liquid	liquid	ADJ
admet-292	1527	16	junction	junction	NOUN
admet-292	1527	17	potentials	potential	NOUN
admet-292	1527	18	.	.	PUNCT
admet-292	1528	1	the	the	DET
admet-292	1528	2	latter	latter	ADJ
admet-292	1528	3	parameter	parameter	NOUN
admet-292	1528	4	may	may	AUX
admet-292	1528	5	also	also	ADV
admet-292	1528	6	compensate	compensate	VERB
admet-292	1528	7	for	for	ADP
admet-292	1528	8	‘	'	PUNCT
admet-292	1528	9	sodium	sodium	NOUN
admet-292	1528	10	error	error	NOUN
admet-292	1528	11	’	'	PUNCT
admet-292	1528	12	when	when	SCONJ
admet-292	1528	13	nacl	nacl	NOUN
admet-292	1528	14	is	be	AUX
admet-292	1528	15	used	use	VERB
admet-292	1528	16	to	to	PART
admet-292	1528	17	adjust	adjust	VERB
admet-292	1528	18	the	the	DET
admet-292	1528	19	ionic	ionic	ADJ
admet-292	1528	20	strength	strength	NOUN
admet-292	1528	21	and/or	and/or	CCONJ
admet-292	1528	22	when	when	SCONJ
admet-292	1528	23	naoh	naoh	NOUN
admet-292	1528	24	is	be	AUX
admet-292	1528	25	the	the	DET
admet-292	1528	26	titrant	titrant	NOUN
admet-292	1528	27	.	.	PUNCT
admet-292	1529	1	in	in	ADP
admet-292	1529	2	a	a	DET
admet-292	1529	3	typical	typical	ADJ
admet-292	1529	4	“	"	PUNCT
admet-292	1529	5	blank	blank	ADJ
admet-292	1529	6	”	"	PUNCT
admet-292	1529	7	titration	titration	NOUN
admet-292	1529	8	procedure	procedure	NOUN
admet-292	1529	9	to	to	PART
admet-292	1529	10	determine	determine	VERB
admet-292	1529	11	the	the	DET
admet-292	1529	12	four	four	NUM
admet-292	1529	13	parameters	parameter	NOUN
admet-292	1529	14	,	,	PUNCT
admet-292	1529	15	about	about	ADV
admet-292	1529	16	0.9	0.9	NUM
admet-292	1529	17	ml	ml	NOUN
admet-292	1529	18	of	of	ADP
admet-292	1529	19	0.5	0.5	NUM
admet-292	1529	20	m	m	PROPN
admet-292	1529	21	hcl	hcl	PROPN
admet-292	1529	22	is	be	AUX
admet-292	1529	23	added	add	VERB
admet-292	1529	24	to	to	ADP
admet-292	1529	25	20	20	NUM
admet-292	1529	26	ml	ml	NOUN
admet-292	1529	27	of	of	ADP
admet-292	1529	28	0.15	0.15	NUM
admet-292	1529	29	m	m	PROPN
admet-292	1529	30	nacl	nacl	NOUN
admet-292	1529	31	(	(	PUNCT
admet-292	1529	32	or	or	CCONJ
admet-292	1529	33	kcl	kcl	NOUN
admet-292	1529	34	)	)	PUNCT
admet-292	1529	35	,	,	PUNCT
admet-292	1529	36	to	to	PART
admet-292	1529	37	lower	lower	VERB
admet-292	1529	38	the	the	DET
admet-292	1529	39	ph	ph	NOUN
admet-292	1529	40	to	to	ADP
admet-292	1529	41	1.8	1.8	NUM
admet-292	1529	42	.	.	PUNCT
admet-292	1530	1	the	the	DET
admet-292	1530	2	solution	solution	NOUN
admet-292	1530	3	is	be	AUX
admet-292	1530	4	then	then	ADV
admet-292	1530	5	carefully	carefully	ADV
admet-292	1530	6	titrated	titrate	VERB
admet-292	1530	7	with	with	ADP
admet-292	1530	8	standardized	standardized	ADJ
admet-292	1530	9	0.5	0.5	NUM
admet-292	1530	10	m	m	NOUN
admet-292	1530	11	naoh	naoh	NOUN
admet-292	1530	12	(	(	PUNCT
admet-292	1530	13	or	or	CCONJ
admet-292	1530	14	koh	koh	PROPN
admet-292	1530	15	)	)	PUNCT
admet-292	1530	16	up	up	ADP
admet-292	1530	17	to	to	ADP
admet-292	1530	18	about	about	ADP
admet-292	1530	19	ph	ph	NOUN
admet-292	1530	20	12.2	12.2	NUM
admet-292	1530	21	(	(	PUNCT
admet-292	1530	22	which	which	PRON
admet-292	1530	23	consumes	consume	VERB
admet-292	1530	24	about	about	ADP
admet-292	1530	25	2.0	2.0	NUM
admet-292	1530	26	ml	ml	NOUN
admet-292	1530	27	of	of	ADP
admet-292	1530	28	the	the	DET
admet-292	1530	29	titrant	titrant	NOUN
admet-292	1530	30	)	)	PUNCT
admet-292	1530	31	.	.	PUNCT
admet-292	1531	1	figure	figure	NOUN
admet-292	1531	2	a2a	a2a	PROPN
admet-292	1531	3	shows	show	VERB
admet-292	1531	4	such	such	DET
admet-292	1531	5	a	a	DET
admet-292	1531	6	plot	plot	NOUN
admet-292	1531	7	.	.	PUNCT
admet-292	1532	1	since	since	SCONJ
admet-292	1532	2	the	the	DET
admet-292	1532	3	ionization	ionization	NOUN
admet-292	1532	4	constant	constant	ADJ
admet-292	1532	5	of	of	ADP
admet-292	1532	6	water	water	NOUN
admet-292	1532	7	is	be	AUX
admet-292	1532	8	known	know	VERB
admet-292	1532	9	over	over	ADP
admet-292	1532	10	a	a	DET
admet-292	1532	11	wide	wide	ADJ
admet-292	1532	12	range	range	NOUN
admet-292	1532	13	of	of	ADP
admet-292	1532	14	conditions	condition	NOUN
admet-292	1532	15	[	[	X
admet-292	1532	16	158	158	NUM
admet-292	1532	17	]	]	PUNCT
admet-292	1532	18	and	and	CCONJ
admet-292	1532	19	since	since	SCONJ
admet-292	1532	20	the	the	DET
admet-292	1532	21	concentrations	concentration	NOUN
admet-292	1532	22	of	of	ADP
admet-292	1532	23	naoh	naoh	NOUN
admet-292	1532	24	and	and	CCONJ
admet-292	1532	25	hcl	hcl	PROPN
admet-292	1532	26	in	in	ADP
admet-292	1532	27	the	the	DET
admet-292	1532	28	titrated	titrate	VERB
admet-292	1532	29	solution	solution	NOUN
admet-292	1532	30	are	be	AUX
admet-292	1532	31	also	also	ADV
admet-292	1532	32	precisely	precisely	ADV
admet-292	1532	33	known	know	VERB
admet-292	1532	34	at	at	ADP
admet-292	1532	35	each	each	DET
admet-292	1532	36	point	point	NOUN
admet-292	1532	37	,	,	PUNCT
admet-292	1532	38	then	then	ADV
admet-292	1532	39	the	the	DET
admet-292	1532	40	hydrogen	hydrogen	NOUN
admet-292	1532	41	ion	ion	NOUN
admet-292	1532	42	concentration	concentration	NOUN
admet-292	1532	43	,	,	PUNCT
admet-292	1532	44	[	[	X
admet-292	1532	45	h	h	NOUN
admet-292	1532	46	+	+	X
admet-292	1532	47	]	]	PUNCT
admet-292	1532	48	,	,	PUNCT
admet-292	1532	49	can	can	AUX
admet-292	1532	50	be	be	AUX
admet-292	1532	51	calculated	calculate	VERB
admet-292	1532	52	,	,	PUNCT
admet-292	1532	53	so	so	SCONJ
admet-292	1532	54	that	that	SCONJ
admet-292	1532	55	at	at	ADP
admet-292	1532	56	each	each	DET
admet-292	1532	57	point	point	NOUN
admet-292	1532	58	in	in	ADP
admet-292	1532	59	the	the	DET
admet-292	1532	60	titration	titration	NOUN
admet-292	1532	61	,	,	PUNCT
admet-292	1532	62	both	both	CCONJ
admet-292	1532	63	the	the	DET
admet-292	1532	64	operational	operational	ADJ
admet-292	1532	65	ph	ph	NOUN
admet-292	1532	66	and	and	CCONJ
admet-292	1532	67	the	the	DET
admet-292	1532	68	concentration	concentration	NOUN
admet-292	1532	69	pch	pch	ADJ
admet-292	1532	70	are	be	AUX
admet-292	1532	71	known	know	VERB
admet-292	1532	72	.	.	PUNCT
admet-292	1533	1	the	the	DET
admet-292	1533	2	parametric	parametric	ADJ
admet-292	1533	3	relationship	relationship	NOUN
admet-292	1533	4	between	between	ADP
admet-292	1533	5	the	the	DET
admet-292	1533	6	two	two	NUM
admet-292	1533	7	scales	scale	NOUN
admet-292	1533	8	can	can	AUX
admet-292	1533	9	be	be	AUX
admet-292	1533	10	deduced	deduce	VERB
admet-292	1533	11	by	by	ADP
admet-292	1533	12	least	least	ADJ
admet-292	1533	13	-	-	PUNCT
admet-292	1533	14	squares	square	NOUN
admet-292	1533	15	fitting	fitting	ADJ
admet-292	1533	16	of	of	ADP
admet-292	1533	17	the	the	DET
admet-292	1533	18	calculated	calculate	VERB
admet-292	1533	19	pch	pch	PROPN
admet-292	1533	20	titration	titration	NOUN
admet-292	1533	21	curve	curve	NOUN
admet-292	1533	22	to	to	ADP
admet-292	1533	23	the	the	DET
admet-292	1533	24	observed	observe	VERB
admet-292	1533	25	ph	ph	NOUN
admet-292	1533	26	titration	titration	NOUN
admet-292	1533	27	data	datum	NOUN
admet-292	1533	28	points	point	NOUN
admet-292	1533	29	.	.	PUNCT
admet-292	1534	1	the	the	DET
admet-292	1534	2	typical	typical	ADJ
admet-292	1534	3	values	value	NOUN
admet-292	1534	4	shown	show	VERB
admet-292	1534	5	in	in	ADP
admet-292	1534	6	table	table	NOUN
admet-292	1534	7	c.1	c.1	NOUN
admet-292	1534	8	(	(	PUNCT
admet-292	1534	9	e.g.	e.g.	ADV
admet-292	1534	10	,	,	PUNCT
admet-292	1534	11	for	for	ADP
admet-292	1534	12	25	25	NUM
admet-292	1534	13	°	°	NOUN
admet-292	1534	14	c	c	NOUN
admet-292	1534	15	,	,	PUNCT
admet-292	1534	16	i	i	NOUN
admet-292	1534	17	=	=	PUNCT
admet-292	1534	18	0.15	0.15	NUM
admet-292	1534	19	m	m	VERB
admet-292	1534	20	)	)	PUNCT
admet-292	1534	21	can	can	AUX
admet-292	1534	22	vary	vary	VERB
admet-292	1534	23	substantially	substantially	ADV
admet-292	1534	24	from	from	ADP
admet-292	1534	25	electrode	electrode	NOUN
admet-292	1534	26	to	to	ADP
admet-292	1534	27	electrode	electrode	NOUN
admet-292	1534	28	:	:	PUNCT
admet-292	1534	29	α	α	NOUN
admet-292	1534	30	=	=	NOUN
admet-292	1534	31	0.08	0.08	NUM
admet-292	1534	32	-	-	SYM
admet-292	1534	33	0.15	0.15	NUM
admet-292	1534	34	,	,	PUNCT
admet-292	1534	35	ks	ks	NOUN
admet-292	1534	36	=	=	NOUN
admet-292	1534	37	0.995	0.995	NUM
admet-292	1534	38	-	-	SYM
admet-292	1534	39	1.005	1.005	NUM
admet-292	1534	40	,	,	PUNCT
admet-292	1534	41	jh	jh	PROPN
admet-292	1534	42	=	=	SYM
admet-292	1534	43	0.5	0.5	NUM
admet-292	1534	44	-	-	SYM
admet-292	1534	45	1.0	1.0	NUM
admet-292	1534	46	or	or	CCONJ
admet-292	1534	47	higher	high	ADJ
admet-292	1534	48	,	,	PUNCT
admet-292	1534	49	and	and	CCONJ
admet-292	1534	50	joh	joh	PROPN
admet-292	1534	51	=	=	SYM
admet-292	1534	52	-0.5	-0.5	PROPN
admet-292	1534	53	or	or	CCONJ
admet-292	1534	54	lower	low	ADJ
admet-292	1534	55	.	.	PUNCT
admet-292	1535	1	for	for	ADP
admet-292	1535	2	a	a	DET
admet-292	1535	3	given	give	VERB
admet-292	1535	4	electrode	electrode	NOUN
admet-292	1535	5	the	the	DET
admet-292	1535	6	precision	precision	NOUN
admet-292	1535	7	of	of	ADP
admet-292	1535	8	the	the	DET
admet-292	1535	9	four	four	NUM
admet-292	1535	10	parameters	parameter	NOUN
admet-292	1535	11	are	be	AUX
admet-292	1535	12	typically	typically	ADV
admet-292	1535	13	±0.02	±0.02	NOUN
admet-292	1535	14	,	,	PUNCT
admet-292	1535	15	±0.002	±0.002	NOUN
admet-292	1535	16	,	,	PUNCT
admet-292	1535	17	±0.2	±0.2	PROPN
admet-292	1535	18	,	,	PUNCT
admet-292	1535	19	and	and	CCONJ
admet-292	1535	20	±0.4	±0.4	PROPN
admet-292	1535	21	,	,	PUNCT
admet-292	1535	22	respectively	respectively	ADV
admet-292	1535	23	.	.	PUNCT
admet-292	1536	1	when	when	SCONJ
admet-292	1536	2	the	the	DET
admet-292	1536	3	differences	difference	NOUN
admet-292	1536	4	ph	ph	VERB
admet-292	1536	5	pch	pch	ADJ
admet-292	1536	6	in	in	ADP
admet-292	1536	7	blank	blank	ADJ
admet-292	1536	8	titrations	titration	NOUN
admet-292	1536	9	are	be	AUX
admet-292	1536	10	examined	examine	VERB
admet-292	1536	11	as	as	ADP
admet-292	1536	12	a	a	DET
admet-292	1536	13	function	function	NOUN
admet-292	1536	14	of	of	ADP
admet-292	1536	15	ph	ph	NOUN
admet-292	1536	16	,	,	PUNCT
admet-292	1536	17	the	the	DET
admet-292	1536	18	variance	variance	NOUN
admet-292	1536	19	in	in	ADP
admet-292	1536	20	the	the	DET
admet-292	1536	21	interval	interval	NOUN
admet-292	1536	22	ph	ph	VERB
admet-292	1536	23	4	4	NUM
admet-292	1536	24	-	-	SYM
admet-292	1536	25	9	9	NUM
admet-292	1536	26	can	can	AUX
admet-292	1536	27	be	be	AUX
admet-292	1536	28	very	very	ADV
admet-292	1536	29	large	large	ADJ
admet-292	1536	30	,	,	PUNCT
admet-292	1536	31	as	as	SCONJ
admet-292	1536	32	is	be	AUX
admet-292	1536	33	expected	expect	VERB
admet-292	1536	34	of	of	ADP
admet-292	1536	35	the	the	DET
admet-292	1536	36	unbuffered	unbuffered	ADJ
admet-292	1536	37	neutral	neutral	ADJ
admet-292	1536	38	ph	ph	NOUN
admet-292	1536	39	region	region	NOUN
admet-292	1536	40	.	.	PUNCT
admet-292	1537	1	regression	regression	NOUN
admet-292	1537	2	determination	determination	NOUN
admet-292	1537	3	of	of	ADP
admet-292	1537	4	the	the	DET
admet-292	1537	5	four	four	NUM
admet-292	1537	6	parameters	parameter	NOUN
admet-292	1537	7	to	to	ADP
admet-292	1537	8	such	such	ADJ
admet-292	1537	9	data	datum	NOUN
admet-292	1537	10	requires	require	VERB
admet-292	1537	11	an	an	DET
admet-292	1537	12	appropriate	appropriate	ADJ
admet-292	1537	13	weighting	weighting	NOUN
admet-292	1537	14	scheme	scheme	NOUN
admet-292	1537	15	[	[	X
admet-292	1537	16	159	159	NUM
admet-292	1537	17	]	]	PUNCT
admet-292	1537	18	.	.	PUNCT
admet-292	1538	1	besides	besides	SCONJ
admet-292	1538	2	the	the	DET
admet-292	1538	3	determination	determination	NOUN
admet-292	1538	4	of	of	ADP
admet-292	1538	5	the	the	DET
admet-292	1538	6	four	four	NUM
admet-292	1538	7	parameters	parameter	NOUN
admet-292	1538	8	,	,	PUNCT
admet-292	1538	9	the	the	DET
admet-292	1538	10	blank	blank	ADJ
admet-292	1538	11	titration	titration	NOUN
admet-292	1538	12	quality	quality	NOUN
admet-292	1538	13	controls	control	VERB
admet-292	1538	14	two	two	NUM
admet-292	1538	15	other	other	ADJ
admet-292	1538	16	experimental	experimental	ADJ
admet-292	1538	17	variables	variable	NOUN
admet-292	1538	18	.	.	PUNCT
admet-292	1539	1	(	(	PUNCT
admet-292	1539	2	a	a	X
admet-292	1539	3	)	)	PUNCT
admet-292	1539	4	the	the	DET
admet-292	1539	5	volume	volume	NOUN
admet-292	1539	6	of	of	ADP
admet-292	1539	7	standardized	standardized	ADJ
admet-292	1539	8	naoh	naoh	NOUN
admet-292	1539	9	needed	need	VERB
admet-292	1539	10	to	to	PART
admet-292	1539	11	neutralize	neutralize	VERB
admet-292	1539	12	the	the	DET
admet-292	1539	13	added	add	VERB
admet-292	1539	14	hcl	hcl	PROPN
admet-292	1539	15	determines	determine	VERB
admet-292	1539	16	the	the	DET
admet-292	1539	17	hcl	hcl	PROPN
admet-292	1539	18	concentration	concentration	NOUN
admet-292	1539	19	very	very	ADV
admet-292	1539	20	precisely	precisely	ADV
admet-292	1539	21	.	.	PUNCT
admet-292	1540	1	(	(	PUNCT
admet-292	1540	2	b	b	X
admet-292	1540	3	)	)	PUNCT
admet-292	1540	4	co2	co2	NOUN
admet-292	1540	5	concentration	concentration	NOUN
admet-292	1540	6	in	in	ADP
admet-292	1540	7	the	the	DET
admet-292	1540	8	0.15	0.15	NUM
admet-292	1540	9	m	m	NOUN
admet-292	1540	10	kcl	kcl	NOUN
admet-292	1540	11	and	and	CCONJ
admet-292	1540	12	in	in	ADP
admet-292	1540	13	the	the	DET
admet-292	1540	14	naoh	naoh	NOUN
admet-292	1540	15	titrant	titrant	NOUN
admet-292	1540	16	can	can	AUX
admet-292	1540	17	be	be	AUX
admet-292	1540	18	precisely	precisely	ADV
admet-292	1540	19	determined	determine	VERB
admet-292	1540	20	,	,	PUNCT
admet-292	1540	21	since	since	SCONJ
admet-292	1540	22	the	the	DET
admet-292	1540	23	neutral	neutral	ADJ
admet-292	1540	24	ph	ph	NOUN
admet-292	1540	25	region	region	NOUN
admet-292	1540	26	clearly	clearly	ADV
admet-292	1540	27	reveals	reveal	VERB
admet-292	1540	28	the	the	DET
admet-292	1540	29	pka	pka	PROPN
admet-292	1540	30	profile	profile	NOUN
admet-292	1540	31	of	of	ADP
admet-292	1540	32	carbonic	carbonic	ADJ
admet-292	1540	33	acid	acid	NOUN
admet-292	1540	34	.	.	PUNCT
admet-292	1541	1	admet	admet	PROPN
admet-292	1541	2	&	&	CCONJ
admet-292	1541	3	dmpk	dmpk	PROPN
admet-292	1541	4	4(2	4(2	NUM
admet-292	1541	5	)	)	PUNCT
admet-292	1541	6	(	(	PUNCT
admet-292	1541	7	2016	2016	NUM
admet-292	1541	8	)	)	PUNCT
admet-292	1541	9	117	117	NUM
admet-292	1541	10	-	-	SYM
admet-292	1541	11	178	178	NUM
admet-292	1541	12	consensus	consensus	NOUN
admet-292	1541	13	recommendations	recommendation	NOUN
admet-292	1541	14	for	for	ADP
admet-292	1541	15	improving	improve	VERB
admet-292	1541	16	solubility	solubility	NOUN
admet-292	1541	17	-	-	PUNCT
admet-292	1541	18	ph	ph	ADJ
admet-292	1541	19	data	datum	NOUN
admet-292	1541	20	quality	quality	NOUN
admet-292	1541	21	doi	doi	NOUN
admet-292	1541	22	:	:	PUNCT
admet-292	1541	23	10.5599	10.5599	NUM
admet-292	1541	24	/	/	SYM
admet-292	1541	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1541	26	169	169	NUM
admet-292	1541	27	appendix	appendix	NOUN
admet-292	1541	28	d	d	NOUN
admet-292	1541	29	questionnaire	questionnaire	NOUN
admet-292	1541	30	summary	summary	NOUN
admet-292	1541	31	ten	ten	NUM
admet-292	1541	32	participants	participant	NOUN
admet-292	1541	33	from	from	ADP
admet-292	1541	34	:	:	PUNCT
admet-292	1541	35	_	_	NOUN
admet-292	1541	36	6	6	NUM
admet-292	1541	37	_	_	X
admet-292	1541	38	_	_	PUNCT
admet-292	1542	1	industry	industry	NOUN
admet-292	1543	1	_	_	PUNCT
admet-292	1543	2	4__academia	4__academia	PUNCT
admet-292	1544	1	_	_	PUNCT
admet-292	1544	2	0__regulatory	0__regulatory	NOUN
admet-292	1544	3	agency	agency	NOUN
admet-292	1545	1	_	_	PUNCT
admet-292	1546	1	0__other	0__other	NOUN
admet-292	1546	2	doing	do	VERB
admet-292	1546	3	solubility	solubility	NOUN
admet-292	1546	4	meausurements	meausurement	NOUN
admet-292	1546	5	:	:	PUNCT
admet-292	1547	1	_	_	NOUN
admet-292	1547	2	8	8	NUM
admet-292	1547	3	_	_	PUNCT
admet-292	1547	4	_	_	PUNCT
admet-292	1548	1	regularly	regularly	ADV
admet-292	1548	2	_	_	PUNCT
admet-292	1549	1	1__occasionally	1__occasionally	ADV
admet-292	1550	1	_	_	PUNCT
admet-292	1550	2	1__never	1__never	NUM
admet-292	1550	3	attended	attend	VERB
admet-292	1550	4	panel	panel	NOUN
admet-292	1550	5	discussion	discussion	NOUN
admet-292	1550	6	:	:	PUNCT
admet-292	1551	1	_	_	NOUN
admet-292	1551	2	9	9	NUM
admet-292	1551	3	_	_	PUNCT
admet-292	1551	4	_	_	PUNCT
admet-292	1552	1	yes	yes	INTJ
admet-292	1553	1	_	_	PUNCT
admet-292	1553	2	1__no	1__no	NUM
admet-292	1553	3	in	in	ADP
admet-292	1553	4	various	various	ADJ
admet-292	1553	5	topic	topic	NOUN
admet-292	1553	6	areas	area	NOUN
admet-292	1553	7	(	(	PUNCT
admet-292	1553	8	italics	italic	NOUN
admet-292	1553	9	below	below	ADV
admet-292	1553	10	)	)	PUNCT
admet-292	1553	11	,	,	PUNCT
admet-292	1553	12	statements	statement	NOUN
admet-292	1553	13	were	be	AUX
admet-292	1553	14	posed	pose	VERB
admet-292	1553	15	(	(	PUNCT
admet-292	1553	16	underlined	underline	VERB
admet-292	1553	17	below	below	ADV
admet-292	1553	18	)	)	PUNCT
admet-292	1553	19	,	,	PUNCT
admet-292	1553	20	and	and	CCONJ
admet-292	1553	21	the	the	DET
admet-292	1553	22	participants	participant	NOUN
admet-292	1553	23	were	be	AUX
admet-292	1553	24	asked	ask	VERB
admet-292	1553	25	if	if	SCONJ
admet-292	1553	26	they	they	PRON
admet-292	1553	27	agreed	agree	VERB
admet-292	1553	28	(	(	PUNCT
admet-292	1553	29	yes	yes	INTJ
admet-292	1553	30	)	)	PUNCT
admet-292	1553	31	,	,	PUNCT
admet-292	1553	32	disagreed	disagree	VERB
admet-292	1553	33	(	(	PUNCT
admet-292	1553	34	no	no	INTJ
admet-292	1553	35	)	)	PUNCT
admet-292	1553	36	,	,	PUNCT
admet-292	1553	37	or	or	CCONJ
admet-292	1553	38	were	be	AUX
admet-292	1553	39	unsure	unsure	ADJ
admet-292	1553	40	(	(	PUNCT
admet-292	1553	41	?	?	PUNCT
admet-292	1553	42	)	)	PUNCT
admet-292	1553	43	regarding	regard	VERB
admet-292	1553	44	the	the	DET
admet-292	1553	45	statement	statement	NOUN
admet-292	1553	46	.	.	PUNCT
admet-292	1554	1	the	the	DET
admet-292	1554	2	counts	count	NOUN
admet-292	1554	3	of	of	ADP
admet-292	1554	4	responses	response	NOUN
admet-292	1554	5	are	be	AUX
admet-292	1554	6	indicated	indicate	VERB
admet-292	1554	7	in	in	ADP
admet-292	1554	8	brackets	bracket	NOUN
admet-292	1554	9	at	at	ADP
admet-292	1554	10	the	the	DET
admet-292	1554	11	beginning	beginning	NOUN
admet-292	1554	12	of	of	ADP
admet-292	1554	13	the	the	DET
admet-292	1554	14	statement	statement	NOUN
admet-292	1554	15	.	.	PUNCT
admet-292	1555	1	additional	additional	ADJ
admet-292	1555	2	comments	comment	NOUN
admet-292	1555	3	are	be	AUX
admet-292	1555	4	in	in	ADP
admet-292	1555	5	quotation	quotation	NOUN
admet-292	1555	6	marks	mark	NOUN
admet-292	1555	7	and	and	CCONJ
admet-292	1555	8	highlighted	highlight	VERB
admet-292	1555	9	in	in	ADP
admet-292	1555	10	yellow	yellow	ADJ
admet-292	1555	11	.	.	PUNCT
admet-292	1556	1	solubility	solubility	NOUN
admet-292	1556	2	units	unit	NOUN
admet-292	1556	3	,	,	PUNCT
admet-292	1556	4	tabulation	tabulation	NOUN
admet-292	1556	5	of	of	ADP
admet-292	1556	6	results	result	NOUN
admet-292	1556	7	and	and	CCONJ
admet-292	1556	8	the	the	DET
admet-292	1556	9	use	use	NOUN
admet-292	1556	10	of	of	ADP
admet-292	1556	11	logarithmic	logarithmic	ADJ
admet-292	1556	12	plots	plot	NOUN
admet-292	1556	13	[	[	X
admet-292	1556	14	9yes	9yes	NUM
admet-292	1556	15	,	,	PUNCT
admet-292	1556	16	1no	1no	ADJ
admet-292	1556	17	]	]	X
admet-292	1556	18	solubility	solubility	NOUN
admet-292	1556	19	needs	need	VERB
admet-292	1556	20	to	to	PART
admet-292	1556	21	be	be	AUX
admet-292	1556	22	tabulated	tabulate	VERB
admet-292	1556	23	both	both	CCONJ
admet-292	1556	24	in	in	ADP
admet-292	1556	25	molarity	molarity	NOUN
admet-292	1556	26	and	and	CCONJ
admet-292	1556	27	in	in	ADP
admet-292	1556	28	practical	practical	ADJ
admet-292	1556	29	(	(	PUNCT
admet-292	1556	30	mg	mg	NOUN
admet-292	1556	31	/	/	SYM
admet-292	1556	32	ml	ml	NOUN
admet-292	1556	33	or	or	CCONJ
admet-292	1556	34	μg	μg	NOUN
admet-292	1556	35	/	/	SYM
admet-292	1556	36	ml	ml	NOUN
admet-292	1556	37	)	)	PUNCT
admet-292	1556	38	units	unit	NOUN
admet-292	1556	39	.	.	PUNCT
admet-292	1557	1	logarithm	logarithm	PROPN
admet-292	1557	2	should	should	AUX
admet-292	1557	3	be	be	AUX
admet-292	1557	4	expressed	express	VERB
admet-292	1557	5	in	in	ADP
admet-292	1557	6	molar	molar	ADJ
admet-292	1557	7	concentrations	concentration	NOUN
admet-292	1557	8	.	.	PUNCT
admet-292	1558	1	“	"	PUNCT
admet-292	1558	2	molarity	molarity	NOUN
admet-292	1558	3	scale	scale	NOUN
admet-292	1558	4	is	be	AUX
admet-292	1558	5	more	more	ADV
admet-292	1558	6	appropriate	appropriate	ADJ
admet-292	1558	7	for	for	ADP
admet-292	1558	8	me	i	PRON
admet-292	1558	9	as	as	ADP
admet-292	1558	10	a	a	DET
admet-292	1558	11	chemist	chemist	NOUN
admet-292	1558	12	.	.	PUNCT
admet-292	1559	1	mw	mw	PROPN
admet-292	1559	2	should	should	AUX
admet-292	1559	3	be	be	AUX
admet-292	1559	4	indicated	indicate	VERB
admet-292	1559	5	together	together	ADV
admet-292	1559	6	with	with	ADP
admet-292	1559	7	molar	molar	ADJ
admet-292	1559	8	solubility	solubility	NOUN
admet-292	1559	9	.	.	PUNCT
admet-292	1559	10	”	"	PUNCT
admet-292	1560	1	“	"	PUNCT
admet-292	1560	2	i	i	PRON
admet-292	1560	3	would	would	AUX
admet-292	1560	4	not	not	PART
admet-292	1560	5	recommend	recommend	VERB
admet-292	1560	6	to	to	PART
admet-292	1560	7	use	use	VERB
admet-292	1560	8	s	s	PRON
admet-292	1560	9	in	in	ADP
admet-292	1560	10	μg	μg	PROPN
admet-292	1560	11	/	/	SYM
admet-292	1560	12	ml	ml	PROPN
admet-292	1560	13	and	and	CCONJ
admet-292	1560	14	logs	log	VERB
admet-292	1560	15	in	in	ADP
admet-292	1560	16	molar	molar	ADJ
admet-292	1560	17	unit	unit	NOUN
admet-292	1560	18	.	.	PUNCT
admet-292	1561	1	as	as	ADP
admet-292	1561	2	for	for	ADP
admet-292	1561	3	me	i	PRON
admet-292	1561	4	i	i	PRON
admet-292	1561	5	would	would	AUX
admet-292	1561	6	always	always	ADV
admet-292	1561	7	use	use	VERB
admet-292	1561	8	the	the	DET
admet-292	1561	9	molar	molar	ADJ
admet-292	1561	10	concentration	concentration	NOUN
admet-292	1561	11	for	for	ADP
admet-292	1561	12	the	the	DET
admet-292	1561	13	solubility	solubility	NOUN
admet-292	1561	14	measures	measure	NOUN
admet-292	1561	15	.	.	PUNCT
admet-292	1562	1	it	it	PRON
admet-292	1562	2	would	would	AUX
admet-292	1562	3	force	force	VERB
admet-292	1562	4	people	people	NOUN
admet-292	1562	5	to	to	PART
admet-292	1562	6	characterize	characterize	VERB
admet-292	1562	7	the	the	DET
admet-292	1562	8	solid	solid	ADJ
admet-292	1562	9	form	form	NOUN
admet-292	1562	10	(	(	PUNCT
admet-292	1562	11	salt	salt	NOUN
admet-292	1562	12	?	?	PUNCT
admet-292	1563	1	not	not	PART
admet-292	1563	2	salt	salt	VERB
admet-292	1563	3	,	,	PUNCT
admet-292	1563	4	partial	partial	ADJ
admet-292	1563	5	)	)	PUNCT
admet-292	1563	6	a	a	DET
admet-292	1563	7	bit	bit	NOUN
admet-292	1563	8	more	more	ADV
admet-292	1563	9	rigorously	rigorously	ADV
admet-292	1563	10	.	.	PUNCT
admet-292	1564	1	in	in	ADP
admet-292	1564	2	the	the	DET
admet-292	1564	3	worst	bad	ADJ
admet-292	1564	4	case	case	NOUN
admet-292	1564	5	scenario	scenario	NOUN
admet-292	1564	6	we	we	PRON
admet-292	1564	7	should	should	AUX
admet-292	1564	8	express	express	VERB
admet-292	1564	9	solubility	solubility	NOUN
admet-292	1564	10	in	in	ADP
admet-292	1564	11	both	both	DET
admet-292	1564	12	units	unit	NOUN
admet-292	1564	13	!	!	PUNCT
admet-292	1564	14	”	"	PUNCT
admet-292	1565	1	[	[	X
admet-292	1565	2	7yes	7ye	NOUN
admet-292	1565	3	,	,	PUNCT
admet-292	1565	4	3no	3no	ADJ
admet-292	1565	5	]	]	PUNCT
admet-292	1565	6	standard	standard	ADJ
admet-292	1565	7	deviations	deviation	NOUN
admet-292	1565	8	in	in	ADP
admet-292	1565	9	measured	measure	VERB
admet-292	1565	10	solubility	solubility	NOUN
admet-292	1565	11	(	(	PUNCT
admet-292	1565	12	based	base	VERB
admet-292	1565	13	on	on	ADP
admet-292	1565	14	averaging	average	VERB
admet-292	1565	15	3	3	NUM
admet-292	1565	16	or	or	CCONJ
admet-292	1565	17	more	more	ADJ
admet-292	1565	18	values	value	NOUN
admet-292	1565	19	)	)	PUNCT
admet-292	1565	20	should	should	AUX
admet-292	1565	21	be	be	AUX
admet-292	1565	22	presented	present	VERB
admet-292	1565	23	.	.	PUNCT
admet-292	1566	1	[	[	X
admet-292	1566	2	9yes	9yes	NUM
admet-292	1566	3	,	,	PUNCT
admet-292	1566	4	1no	1no	ADJ
admet-292	1566	5	]	]	PUNCT
admet-292	1566	6	additionally	additionally	ADV
admet-292	1566	7	,	,	PUNCT
admet-292	1566	8	a	a	DET
admet-292	1566	9	graphical	graphical	ADJ
admet-292	1566	10	display	display	NOUN
admet-292	1566	11	of	of	ADP
admet-292	1566	12	logs	log	NOUN
admet-292	1566	13	vs.	vs.	X
admet-292	1566	14	ph	ph	NOUN
admet-292	1566	15	(	(	PUNCT
admet-292	1566	16	but	but	CCONJ
admet-292	1566	17	not	not	PART
admet-292	1566	18	s	s	PROPN
admet-292	1566	19	vs.	vs.	X
admet-292	1566	20	ph	ph	NOUN
admet-292	1566	21	–	–	PUNCT
admet-292	1566	22	unless	unless	SCONJ
admet-292	1566	23	tabulated	tabulate	VERB
admet-292	1566	24	numbers	number	NOUN
admet-292	1566	25	are	be	AUX
admet-292	1566	26	also	also	ADV
admet-292	1566	27	available	available	ADJ
admet-292	1566	28	)	)	PUNCT
admet-292	1566	29	would	would	AUX
admet-292	1566	30	be	be	AUX
admet-292	1566	31	visually	visually	ADV
admet-292	1566	32	helpful	helpful	ADJ
admet-292	1566	33	.	.	PUNCT
admet-292	1567	1	solubility	solubility	NOUN
admet-292	1567	2	methodology	methodology	NOUN
admet-292	1567	3	and	and	CCONJ
admet-292	1567	4	the	the	DET
admet-292	1567	5	benefits	benefit	NOUN
admet-292	1567	6	of	of	ADP
admet-292	1567	7	knowing	know	VERB
admet-292	1567	8	the	the	DET
admet-292	1567	9	accurate	accurate	ADJ
admet-292	1567	10	pka	pka	PROPN
admet-292	1567	11	[	[	X
admet-292	1567	12	10yes	10yes	X
admet-292	1567	13	]	]	X
admet-292	1567	14	the	the	DET
admet-292	1567	15	“	"	PUNCT
admet-292	1567	16	gold	gold	ADJ
admet-292	1567	17	standard	standard	NOUN
admet-292	1567	18	”	"	PUNCT
admet-292	1567	19	multiple	multiple	ADJ
admet-292	1567	20	-	-	PUNCT
admet-292	1567	21	ph	ph	ADJ
admet-292	1567	22	buffer	buffer	NOUN
admet-292	1567	23	shake	shake	NOUN
admet-292	1567	24	-	-	PUNCT
admet-292	1567	25	flask	flask	NOUN
admet-292	1567	26	measurement	measurement	NOUN
admet-292	1567	27	is	be	AUX
admet-292	1567	28	recommended	recommend	VERB
admet-292	1567	29	for	for	ADP
admet-292	1567	30	challenging	challenge	VERB
admet-292	1567	31	ionizable	ionizable	ADJ
admet-292	1567	32	molecules	molecule	NOUN
admet-292	1567	33	.	.	PUNCT
admet-292	1568	1	“	"	PUNCT
admet-292	1568	2	[	[	X
admet-292	1568	3	i	i	PRON
admet-292	1568	4	would	would	AUX
admet-292	1568	5	agree	agree	VERB
admet-292	1568	6	]	]	PUNCT
admet-292	1568	7	as	as	ADV
admet-292	1568	8	long	long	ADV
admet-292	1568	9	as	as	SCONJ
admet-292	1568	10	“	"	PUNCT
admet-292	1568	11	shake	shake	VERB
admet-292	1568	12	-	-	PUNCT
admet-292	1568	13	flask	flask	NOUN
admet-292	1568	14	”	"	PUNCT
admet-292	1568	15	is	be	AUX
admet-292	1568	16	broadly	broadly	ADV
admet-292	1568	17	understood	understand	VERB
admet-292	1568	18	–	–	PUNCT
admet-292	1568	19	in	in	ADP
admet-292	1568	20	situ	situ	ADJ
admet-292	1568	21	uv	uv	NOUN
admet-292	1568	22	concentration	concentration	NOUN
admet-292	1568	23	monitoring	monitoring	NOUN
admet-292	1568	24	,	,	PUNCT
admet-292	1568	25	for	for	ADP
admet-292	1568	26	example	example	NOUN
admet-292	1568	27	,	,	PUNCT
admet-292	1568	28	is	be	AUX
admet-292	1568	29	a	a	DET
admet-292	1568	30	“	"	PUNCT
admet-292	1568	31	shake	shake	VERB
admet-292	1568	32	-	-	PUNCT
admet-292	1568	33	flask	flask	NOUN
admet-292	1568	34	”	"	PUNCT
admet-292	1568	35	measurement	measurement	NOUN
admet-292	1568	36	of	of	ADP
admet-292	1568	37	sort	sort	NOUN
admet-292	1568	38	.	.	PUNCT
admet-292	1568	39	”	"	PUNCT
admet-292	1569	1	which	which	PRON
admet-292	1569	2	other	other	ADJ
admet-292	1569	3	methods	method	NOUN
admet-292	1569	4	may	may	AUX
admet-292	1569	5	also	also	ADV
admet-292	1569	6	be	be	AUX
admet-292	1569	7	satisfactory	satisfactory	ADJ
admet-292	1569	8	(	(	PUNCT
admet-292	1569	9	with	with	SCONJ
admet-292	1569	10	the	the	DET
admet-292	1569	11	henderson	henderson	PROPN
admet-292	1569	12	-	-	PUNCT
admet-292	1569	13	hasselbalch	hasselbalch	PROPN
admet-292	1569	14	relationship	relationship	NOUN
admet-292	1569	15	independently	independently	ADV
admet-292	1569	16	validated	validate	VERB
admet-292	1569	17	):	):	PUNCT
admet-292	1570	1	[	[	X
admet-292	1570	2	3	3	NUM
admet-292	1570	3	cheqsol	cheqsol	NOUN
admet-292	1570	4	;	;	PUNCT
admet-292	1570	5	2	2	NUM
admet-292	1570	6	potentiometry	potentiometry	NOUN
admet-292	1570	7	;	;	PUNCT
admet-292	1570	8	1	1	NUM
admet-292	1570	9	direct	direct	ADJ
admet-292	1570	10	microscopic	microscopic	ADJ
admet-292	1570	11	obs	obs	PROPN
admet-292	1570	12	.	.	PUNCT
admet-292	1571	1	of	of	ADP
admet-292	1571	2	drop	drop	NOUN
admet-292	1571	3	;	;	PUNCT
admet-292	1571	4	1	1	NUM
admet-292	1571	5	pxrd	pxrd	NOUN
admet-292	1571	6	;	;	PUNCT
admet-292	1571	7	1	1	NUM
admet-292	1571	8	dissolution	dissolution	NOUN
admet-292	1571	9	calorimetry	calorimetry	NOUN
admet-292	1571	10	]	]	PUNCT
admet-292	1572	1	[	[	X
admet-292	1572	2	10yes	10yes	X
admet-292	1572	3	]	]	X
admet-292	1572	4	miniaturization	miniaturization	NOUN
admet-292	1572	5	(	(	PUNCT
admet-292	1572	6	0.2	0.2	NUM
admet-292	1572	7	–	–	SYM
admet-292	1572	8	2	2	NUM
admet-292	1572	9	ml	ml	NOUN
admet-292	1572	10	)	)	PUNCT
admet-292	1572	11	can	can	AUX
admet-292	1572	12	be	be	AUX
admet-292	1572	13	recommended	recommend	VERB
admet-292	1572	14	,	,	PUNCT
admet-292	1572	15	as	as	ADV
admet-292	1572	16	long	long	ADV
admet-292	1572	17	as	as	SCONJ
admet-292	1572	18	the	the	DET
admet-292	1572	19	protocols	protocol	NOUN
admet-292	1572	20	are	be	AUX
admet-292	1572	21	rigorous	rigorous	ADJ
admet-292	1572	22	and	and	CCONJ
admet-292	1572	23	well	well	ADV
admet-292	1572	24	validated	validate	VERB
admet-292	1572	25	.	.	PUNCT
admet-292	1573	1	[	[	X
admet-292	1573	2	10yes	10yes	X
admet-292	1573	3	]	]	X
admet-292	1573	4	for	for	ADP
admet-292	1573	5	ionizable	ionizable	ADJ
admet-292	1573	6	molecules	molecule	NOUN
admet-292	1573	7	,	,	PUNCT
admet-292	1573	8	the	the	DET
admet-292	1573	9	measurement	measurement	NOUN
admet-292	1573	10	of	of	ADP
admet-292	1573	11	sw	sw	PROPN
admet-292	1573	12	without	without	ADP
admet-292	1573	13	measuring	measure	VERB
admet-292	1573	14	the	the	DET
admet-292	1573	15	equilibrium	equilibrium	NOUN
admet-292	1573	16	ph	ph	NOUN
admet-292	1573	17	is	be	AUX
admet-292	1573	18	not	not	PART
admet-292	1573	19	alex	alex	PROPN
admet-292	1573	20	avdeef	avdeef	PROPN
admet-292	1573	21	et	et	PROPN
admet-292	1573	22	al	al	PROPN
admet-292	1573	23	.	.	PROPN
admet-292	1573	24	admet	admet	PROPN
admet-292	1573	25	&	&	CCONJ
admet-292	1573	26	dmpk	dmpk	PROPN
admet-292	1573	27	4(2	4(2	NUM
admet-292	1573	28	)	)	PUNCT
admet-292	1573	29	(	(	PUNCT
admet-292	1573	30	2016	2016	NUM
admet-292	1573	31	)	)	PUNCT
admet-292	1573	32	117	117	NUM
admet-292	1573	33	-	-	SYM
admet-292	1573	34	178	178	NUM
admet-292	1573	35	170	170	NUM
admet-292	1573	36	recommended	recommend	VERB
admet-292	1573	37	.	.	PUNCT
admet-292	1574	1	“	"	PUNCT
admet-292	1574	2	water	water	NOUN
admet-292	1574	3	solubility	solubility	NOUN
admet-292	1574	4	may	may	AUX
admet-292	1574	5	be	be	AUX
admet-292	1574	6	of	of	ADP
admet-292	1574	7	practical	practical	ADJ
admet-292	1574	8	interest	interest	NOUN
admet-292	1574	9	,	,	PUNCT
admet-292	1574	10	but	but	CCONJ
admet-292	1574	11	it	it	PRON
admet-292	1574	12	must	must	AUX
admet-292	1574	13	be	be	AUX
admet-292	1574	14	complemented	complement	VERB
admet-292	1574	15	,	,	PUNCT
admet-292	1574	16	not	not	PART
admet-292	1574	17	substitute	substitute	VERB
admet-292	1574	18	the	the	DET
admet-292	1574	19	procedure	procedure	NOUN
admet-292	1574	20	described	describe	VERB
admet-292	1574	21	above	above	ADV
admet-292	1574	22	.	.	PUNCT
admet-292	1574	23	”	"	PUNCT
admet-292	1575	1	[	[	X
admet-292	1575	2	10yes	10yes	X
admet-292	1575	3	]	]	X
admet-292	1575	4	it	it	PRON
admet-292	1575	5	is	be	AUX
admet-292	1575	6	far	far	ADV
admet-292	1575	7	better	well	ADJ
admet-292	1575	8	to	to	PART
admet-292	1575	9	measure	measure	VERB
admet-292	1575	10	sph	sph	NOUN
admet-292	1575	11	values	value	NOUN
admet-292	1575	12	in	in	ADP
admet-292	1575	13	well	well	ADV
admet-292	1575	14	-	-	PUNCT
admet-292	1575	15	qualified	qualified	ADJ
admet-292	1575	16	buffers	buffer	NOUN
admet-292	1575	17	,	,	PUNCT
admet-292	1575	18	at	at	ADP
admet-292	1575	19	3	3	NUM
admet-292	1575	20	or	or	CCONJ
admet-292	1575	21	more	more	ADJ
admet-292	1575	22	equilibrated	equilibrated	ADJ
admet-292	1575	23	ph	ph	ADJ
admet-292	1575	24	values	value	NOUN
admet-292	1575	25	,	,	PUNCT
admet-292	1575	26	symmetrically	symmetrically	ADV
admet-292	1575	27	bracketing	bracket	VERB
admet-292	1575	28	the	the	DET
admet-292	1575	29	pka	pka	NOUN
admet-292	1575	30	.	.	PUNCT
admet-292	1576	1	[	[	X
admet-292	1576	2	8yes	8yes	NUM
admet-292	1576	3	,	,	PUNCT
admet-292	1576	4	2no	2no	NOUN
admet-292	1576	5	]	]	PUNCT
admet-292	1577	1	the	the	DET
admet-292	1577	2	logs	log	NOUN
admet-292	1577	3	–	–	PUNCT
admet-292	1577	4	ph	ph	ADJ
admet-292	1577	5	data	datum	NOUN
admet-292	1577	6	should	should	AUX
admet-292	1577	7	be	be	AUX
admet-292	1577	8	evaluated	evaluate	VERB
admet-292	1577	9	to	to	PART
admet-292	1577	10	estimate	estimate	VERB
admet-292	1577	11	the	the	DET
admet-292	1577	12	value	value	NOUN
admet-292	1577	13	of	of	ADP
admet-292	1577	14	the	the	DET
admet-292	1577	15	intrinsic	intrinsic	ADJ
admet-292	1577	16	solubility	solubility	NOUN
admet-292	1577	17	,	,	PUNCT
admet-292	1577	18	s0	s0	PROPN
admet-292	1577	19	.	.	PUNCT
admet-292	1578	1	[	[	X
admet-292	1578	2	10yes	10yes	X
admet-292	1578	3	]	]	X
admet-292	1578	4	solubility	solubility	NOUN
admet-292	1578	5	is	be	AUX
admet-292	1578	6	a	a	DET
admet-292	1578	7	function	function	NOUN
admet-292	1578	8	of	of	ADP
admet-292	1578	9	temperature	temperature	NOUN
admet-292	1578	10	,	,	PUNCT
admet-292	1578	11	so	so	ADV
admet-292	1578	12	the	the	DET
admet-292	1578	13	actual	actual	ADJ
admet-292	1578	14	assay	assay	NOUN
admet-292	1578	15	temperature	temperature	NOUN
admet-292	1578	16	needs	need	VERB
admet-292	1578	17	to	to	PART
admet-292	1578	18	be	be	AUX
admet-292	1578	19	reported	report	VERB
admet-292	1578	20	.	.	PUNCT
admet-292	1579	1	“	"	PUNCT
admet-292	1579	2	measurements	measurement	NOUN
admet-292	1579	3	at	at	ADP
admet-292	1579	4	multiple	multiple	ADJ
admet-292	1579	5	temperatures	temperature	NOUN
admet-292	1579	6	are	be	AUX
admet-292	1579	7	highly	highly	ADV
admet-292	1579	8	desirable	desirable	ADJ
admet-292	1579	9	,	,	PUNCT
admet-292	1579	10	since	since	SCONJ
admet-292	1579	11	they	they	PRON
admet-292	1579	12	may	may	AUX
admet-292	1579	13	indicate	indicate	VERB
admet-292	1579	14	also	also	ADV
admet-292	1579	15	at	at	ADP
admet-292	1579	16	important	important	ADJ
admet-292	1579	17	changes	change	NOUN
admet-292	1579	18	in	in	ADP
admet-292	1579	19	the	the	DET
admet-292	1579	20	dissolution	dissolution	NOUN
admet-292	1579	21	mechanism	mechanism	NOUN
admet-292	1579	22	.	.	PUNCT
admet-292	1579	23	”	"	PUNCT
admet-292	1580	1	“	"	PUNCT
admet-292	1580	2	graphs	graph	NOUN
admet-292	1580	3	vs.	vs.	ADP
admet-292	1580	4	t	t	PROPN
admet-292	1580	5	are	be	AUX
admet-292	1580	6	also	also	ADV
admet-292	1580	7	helpful	helpful	ADJ
admet-292	1580	8	.	.	PUNCT
admet-292	1580	9	”	"	PUNCT
admet-292	1581	1	[	[	X
admet-292	1581	2	6yes	6ye	NOUN
admet-292	1581	3	,	,	PUNCT
admet-292	1581	4	4	4	NUM
admet-292	1581	5	?	?	SYM
admet-292	1581	6	]	]	PUNCT
admet-292	1581	7	if	if	SCONJ
admet-292	1581	8	solubility	solubility	NOUN
admet-292	1581	9	is	be	AUX
admet-292	1581	10	measured	measure	VERB
admet-292	1581	11	at	at	ADP
admet-292	1581	12	several	several	ADJ
admet-292	1581	13	different	different	ADJ
admet-292	1581	14	temperatures	temperature	NOUN
admet-292	1581	15	,	,	PUNCT
admet-292	1581	16	it	it	PRON
admet-292	1581	17	is	be	AUX
admet-292	1581	18	normal	normal	ADJ
admet-292	1581	19	to	to	PART
admet-292	1581	20	report	report	VERB
admet-292	1581	21	solubility	solubility	NOUN
admet-292	1581	22	in	in	ADP
admet-292	1581	23	either	either	CCONJ
admet-292	1581	24	mole	mole	NOUN
admet-292	1581	25	fraction	fraction	NOUN
admet-292	1581	26	(	(	PUNCT
admet-292	1581	27	x2	x2	NOUN
admet-292	1581	28	)	)	PUNCT
admet-292	1581	29	or	or	CCONJ
admet-292	1581	30	molality	molality	NOUN
admet-292	1581	31	(	(	PUNCT
admet-292	1581	32	mol	mol	PROPN
admet-292	1581	33	/	/	SYM
admet-292	1581	34	kg	kg	PROPN
admet-292	1581	35	solvent	solvent	NOUN
admet-292	1581	36	)	)	PUNCT
admet-292	1581	37	units	unit	NOUN
admet-292	1581	38	.	.	PUNCT
admet-292	1582	1	it	it	PRON
admet-292	1582	2	would	would	AUX
admet-292	1582	3	be	be	AUX
admet-292	1582	4	very	very	ADV
admet-292	1582	5	helpful	helpful	ADJ
admet-292	1582	6	also	also	ADV
admet-292	1582	7	to	to	PART
admet-292	1582	8	include	include	VERB
admet-292	1582	9	the	the	DET
admet-292	1582	10	solubility	solubility	NOUN
admet-292	1582	11	in	in	ADP
admet-292	1582	12	molarity	molarity	NOUN
admet-292	1582	13	units	unit	NOUN
admet-292	1582	14	(	(	PUNCT
admet-292	1582	15	mol	mol	ADP
admet-292	1582	16	/	/	SYM
admet-292	1582	17	l	l	NOUN
admet-292	1582	18	solution	solution	NOUN
admet-292	1582	19	)	)	PUNCT
admet-292	1582	20	.	.	PUNCT
admet-292	1583	1	“	"	PUNCT
admet-292	1583	2	we	we	PRON
admet-292	1583	3	think	think	VERB
admet-292	1583	4	it	it	PRON
admet-292	1583	5	is	be	AUX
admet-292	1583	6	better	well	ADJ
admet-292	1583	7	to	to	PART
admet-292	1583	8	provide	provide	VERB
admet-292	1583	9	molar	molar	ADJ
admet-292	1583	10	solubility	solubility	NOUN
admet-292	1583	11	always	always	ADV
admet-292	1583	12	,	,	PUNCT
admet-292	1583	13	indicating	indicate	VERB
admet-292	1583	14	the	the	DET
admet-292	1583	15	temperature	temperature	NOUN
admet-292	1583	16	of	of	ADP
admet-292	1583	17	each	each	DET
admet-292	1583	18	measurement	measurement	NOUN
admet-292	1583	19	.	.	PUNCT
admet-292	1583	20	”	"	PUNCT
admet-292	1584	1	[	[	X
admet-292	1584	2	10yes	10yes	X
admet-292	1584	3	]	]	PUNCT
admet-292	1584	4	measured	measure	VERB
admet-292	1584	5	solubility	solubility	NOUN
admet-292	1584	6	can	can	AUX
admet-292	1584	7	be	be	AUX
admet-292	1584	8	affected	affect	VERB
admet-292	1584	9	by	by	ADP
admet-292	1584	10	ionic	ionic	ADJ
admet-292	1584	11	strength	strength	NOUN
admet-292	1584	12	(	(	PUNCT
admet-292	1584	13	particularly	particularly	ADV
admet-292	1584	14	when	when	SCONJ
admet-292	1584	15	salt	salt	NOUN
admet-292	1584	16	solubility	solubility	NOUN
admet-292	1584	17	is	be	AUX
admet-292	1584	18	measured	measure	VERB
admet-292	1584	19	)	)	PUNCT
admet-292	1584	20	,	,	PUNCT
admet-292	1584	21	so	so	CCONJ
admet-292	1584	22	the	the	DET
admet-292	1584	23	ionic	ionic	ADJ
admet-292	1584	24	strength	strength	NOUN
admet-292	1584	25	usually	usually	ADV
admet-292	1584	26	needs	need	VERB
admet-292	1584	27	to	to	PART
admet-292	1584	28	be	be	AUX
admet-292	1584	29	reported	report	VERB
admet-292	1584	30	.	.	PUNCT
admet-292	1585	1	it	it	PRON
admet-292	1585	2	is	be	AUX
admet-292	1585	3	easy	easy	ADJ
admet-292	1585	4	to	to	PART
admet-292	1585	5	calculate	calculate	VERB
admet-292	1585	6	the	the	DET
admet-292	1585	7	ionic	ionic	ADJ
admet-292	1585	8	strength	strength	NOUN
admet-292	1585	9	coming	come	VERB
admet-292	1585	10	from	from	ADP
admet-292	1585	11	the	the	DET
admet-292	1585	12	buffers	buffer	NOUN
admet-292	1585	13	and	and	CCONJ
admet-292	1585	14	the	the	DET
admet-292	1585	15	adjustors	adjustor	NOUN
admet-292	1585	16	,	,	PUNCT
admet-292	1585	17	but	but	CCONJ
admet-292	1585	18	it	it	PRON
admet-292	1585	19	is	be	AUX
admet-292	1585	20	not	not	PART
admet-292	1585	21	evident	evident	ADJ
admet-292	1585	22	how	how	SCONJ
admet-292	1585	23	to	to	PART
admet-292	1585	24	contemplate	contemplate	VERB
admet-292	1585	25	the	the	DET
admet-292	1585	26	contribution	contribution	NOUN
admet-292	1585	27	of	of	ADP
admet-292	1585	28	the	the	DET
admet-292	1585	29	own	own	ADJ
admet-292	1585	30	sample	sample	NOUN
admet-292	1585	31	.	.	PUNCT
admet-292	1586	1	equilibration	equilibration	NOUN
admet-292	1586	2	time	time	NOUN
admet-292	1586	3	and	and	CCONJ
admet-292	1586	4	stirring	stir	VERB
admet-292	1586	5	protocol	protocol	NOUN
admet-292	1587	1	[	[	X
admet-292	1587	2	9yes	9yes	NUM
admet-292	1587	3	,	,	PUNCT
admet-292	1587	4	1	1	NUM
admet-292	1587	5	?	?	NUM
admet-292	1587	6	]	]	PUNCT
admet-292	1587	7	ordinarily	ordinarily	ADV
admet-292	1587	8	,	,	PUNCT
admet-292	1587	9	the	the	DET
admet-292	1587	10	shake	shake	NOUN
admet-292	1587	11	-	-	PUNCT
admet-292	1587	12	flask	flask	NOUN
admet-292	1587	13	method	method	NOUN
admet-292	1587	14	determines	determine	VERB
admet-292	1587	15	the	the	DET
admet-292	1587	16	equilibrium	equilibrium	NOUN
admet-292	1587	17	solubility	solubility	NOUN
admet-292	1587	18	of	of	ADP
admet-292	1587	19	the	the	DET
admet-292	1587	20	most	most	ADV
admet-292	1587	21	stable	stable	ADJ
admet-292	1587	22	solid	solid	ADJ
admet-292	1587	23	state	state	NOUN
admet-292	1587	24	form	form	NOUN
admet-292	1587	25	of	of	ADP
admet-292	1587	26	the	the	DET
admet-292	1587	27	compound	compound	NOUN
admet-292	1587	28	(	(	PUNCT
admet-292	1587	29	which	which	PRON
admet-292	1587	30	may	may	AUX
admet-292	1587	31	be	be	AUX
admet-292	1587	32	different	different	ADJ
admet-292	1587	33	from	from	ADP
admet-292	1587	34	the	the	DET
admet-292	1587	35	original	original	ADJ
admet-292	1587	36	solid	solid	ADJ
admet-292	1587	37	form	form	NOUN
admet-292	1587	38	added	add	VERB
admet-292	1587	39	to	to	ADP
admet-292	1587	40	the	the	DET
admet-292	1587	41	suspension	suspension	NOUN
admet-292	1587	42	)	)	PUNCT
admet-292	1587	43	.	.	PUNCT
admet-292	1588	1	“	"	PUNCT
admet-292	1588	2	i	i	PRON
admet-292	1588	3	am	be	AUX
admet-292	1588	4	not	not	PART
admet-292	1588	5	sure	sure	ADJ
admet-292	1588	6	about	about	ADP
admet-292	1588	7	‘	'	PUNCT
admet-292	1588	8	the	the	DET
admet-292	1588	9	most	most	ADV
admet-292	1588	10	stable	stable	ADJ
admet-292	1588	11	form	form	NOUN
admet-292	1588	12	,	,	PUNCT
admet-292	1588	13	’	'	PUNCT
admet-292	1588	14	but	but	CCONJ
admet-292	1588	15	the	the	DET
admet-292	1588	16	two	two	NUM
admet-292	1588	17	forms	form	NOUN
admet-292	1588	18	may	may	AUX
admet-292	1588	19	immensely	immensely	ADV
admet-292	1588	20	differ	differ	VERB
admet-292	1588	21	.	.	PUNCT
admet-292	1588	22	”	"	PUNCT
admet-292	1589	1	“	"	PUNCT
admet-292	1589	2	it	it	PRON
admet-292	1589	3	is	be	AUX
admet-292	1589	4	recommended	recommend	VERB
admet-292	1589	5	to	to	PART
admet-292	1589	6	prove	prove	VERB
admet-292	1589	7	this	this	PRON
admet-292	1589	8	by	by	ADP
admet-292	1589	9	alternative	alternative	ADJ
admet-292	1589	10	method	method	NOUN
admet-292	1589	11	,	,	PUNCT
admet-292	1589	12	dsc	dsc	NOUN
admet-292	1589	13	,	,	PUNCT
admet-292	1589	14	or	or	CCONJ
admet-292	1589	15	pxrd	pxrd	NOUN
admet-292	1589	16	.	.	PUNCT
admet-292	1589	17	”	"	PUNCT
admet-292	1590	1	“	"	PUNCT
admet-292	1590	2	it	it	PRON
admet-292	1590	3	would	would	AUX
admet-292	1590	4	be	be	AUX
admet-292	1590	5	beneficial	beneficial	ADJ
admet-292	1590	6	to	to	PART
admet-292	1590	7	confirm	confirm	VERB
admet-292	1590	8	the	the	DET
admet-292	1590	9	solid	solid	ADJ
admet-292	1590	10	state	state	NOUN
admet-292	1590	11	after	after	SCONJ
admet-292	1590	12	solubility	solubility	NOUN
admet-292	1590	13	measurements	measurement	VERB
admet-292	1590	14	especially	especially	ADV
admet-292	1590	15	if	if	SCONJ
admet-292	1590	16	the	the	DET
admet-292	1590	17	measurement	measurement	NOUN
admet-292	1590	18	relies	rely	VERB
admet-292	1590	19	on	on	ADP
admet-292	1590	20	precipitation	precipitation	NOUN
admet-292	1590	21	.	.	PUNCT
admet-292	1590	22	”	"	PUNCT
admet-292	1591	1	[	[	X
admet-292	1591	2	6yes	6ye	NOUN
admet-292	1591	3	,	,	PUNCT
admet-292	1591	4	3no	3no	ADJ
admet-292	1591	5	,	,	PUNCT
admet-292	1591	6	1	1	NUM
admet-292	1591	7	?	?	NUM
admet-292	1591	8	]	]	X
admet-292	1591	9	probably	probably	ADV
admet-292	1591	10	24	24	NUM
admet-292	1591	11	h	h	NOUN
admet-292	1591	12	is	be	AUX
admet-292	1591	13	a	a	DET
admet-292	1591	14	good	good	ADJ
admet-292	1591	15	average	average	ADJ
admet-292	1591	16	equilibration	equilibration	NOUN
admet-292	1591	17	time	time	NOUN
admet-292	1591	18	for	for	ADP
admet-292	1591	19	the	the	DET
admet-292	1591	20	uncharged	uncharged	ADJ
admet-292	1591	21	drug	drug	NOUN
admet-292	1591	22	form	form	NOUN
admet-292	1591	23	equilibration	equilibration	NOUN
admet-292	1591	24	,	,	PUNCT
admet-292	1591	25	but	but	CCONJ
admet-292	1591	26	when	when	SCONJ
admet-292	1591	27	measuring	measure	VERB
admet-292	1591	28	the	the	DET
admet-292	1591	29	equilibrium	equilibrium	NOUN
admet-292	1591	30	solubility	solubility	NOUN
admet-292	1591	31	of	of	ADP
admet-292	1591	32	practically	practically	ADV
admet-292	1591	33	-	-	PUNCT
admet-292	1591	34	insoluble	insoluble	ADJ
admet-292	1591	35	drugs	drug	NOUN
admet-292	1591	36	it	it	PRON
admet-292	1591	37	is	be	AUX
admet-292	1591	38	a	a	DET
admet-292	1591	39	good	good	ADJ
admet-292	1591	40	idea	idea	NOUN
admet-292	1591	41	to	to	PART
admet-292	1591	42	test	test	VERB
admet-292	1591	43	longer	long	ADJ
admet-292	1591	44	times	time	NOUN
admet-292	1591	45	(	(	PUNCT
admet-292	1591	46	e.g.	e.g.	ADV
admet-292	1591	47	,	,	PUNCT
admet-292	1591	48	48–72	48–72	NUM
admet-292	1591	49	h	h	NOUN
admet-292	1591	50	)	)	PUNCT
admet-292	1591	51	.	.	PUNCT
admet-292	1592	1	in	in	ADP
admet-292	1592	2	regions	region	NOUN
admet-292	1592	3	of	of	ADP
admet-292	1592	4	ph	ph	NOUN
admet-292	1592	5	where	where	SCONJ
admet-292	1592	6	the	the	DET
admet-292	1592	7	sample	sample	NOUN
admet-292	1592	8	molecule	molecule	NOUN
admet-292	1592	9	is	be	AUX
admet-292	1592	10	predominantly	predominantly	ADV
admet-292	1592	11	ionized	ionize	VERB
admet-292	1592	12	(	(	PUNCT
admet-292	1592	13	e.g.	e.g.	ADV
admet-292	1592	14	,	,	PUNCT
admet-292	1592	15	salt	salt	NOUN
admet-292	1592	16	solubility	solubility	NOUN
admet-292	1592	17	applications	application	NOUN
admet-292	1592	18	)	)	PUNCT
admet-292	1592	19	,	,	PUNCT
admet-292	1592	20	equilibration	equilibration	NOUN
admet-292	1592	21	times	time	NOUN
admet-292	1592	22	as	as	ADV
admet-292	1592	23	short	short	ADJ
admet-292	1592	24	as	as	ADP
admet-292	1592	25	1	1	NUM
admet-292	1592	26	-	-	SYM
admet-292	1592	27	6	6	NUM
admet-292	1592	28	h	h	NOUN
admet-292	1592	29	may	may	AUX
admet-292	1592	30	be	be	AUX
admet-292	1592	31	adequate	adequate	ADJ
admet-292	1592	32	.	.	PUNCT
admet-292	1593	1	“	"	PUNCT
admet-292	1593	2	ph	ph	ADJ
admet-292	1593	3	control	control	NOUN
admet-292	1593	4	is	be	AUX
admet-292	1593	5	a	a	DET
admet-292	1593	6	good	good	ADJ
admet-292	1593	7	tool	tool	NOUN
admet-292	1593	8	to	to	PART
admet-292	1593	9	see	see	VERB
admet-292	1593	10	if	if	SCONJ
admet-292	1593	11	equilibrium	equilibrium	NOUN
admet-292	1593	12	has	have	AUX
admet-292	1593	13	been	be	AUX
admet-292	1593	14	reached	reach	VERB
admet-292	1593	15	.	.	PUNCT
admet-292	1593	16	”	"	PUNCT
admet-292	1594	1	“	"	PUNCT
admet-292	1594	2	it	it	PRON
admet-292	1594	3	is	be	AUX
admet-292	1594	4	helpful	helpful	ADJ
admet-292	1594	5	to	to	PART
admet-292	1594	6	have	have	VERB
admet-292	1594	7	measurement	measurement	NOUN
admet-292	1594	8	during	during	ADP
admet-292	1594	9	the	the	DET
admet-292	1594	10	incubation	incubation	NOUN
admet-292	1594	11	time	time	NOUN
admet-292	1594	12	.	.	PUNCT
admet-292	1594	13	”	"	PUNCT
admet-292	1595	1	[	[	X
admet-292	1595	2	5yes	5ye	NOUN
admet-292	1595	3	,	,	PUNCT
admet-292	1595	4	3no	3no	ADJ
admet-292	1595	5	,	,	PUNCT
admet-292	1595	6	2	2	NUM
admet-292	1595	7	?	?	NUM
admet-292	1595	8	]	]	X
admet-292	1595	9	the	the	DET
admet-292	1595	10	25	25	NUM
admet-292	1595	11	%	%	NOUN
admet-292	1595	12	stir	stir	NOUN
admet-292	1595	13	+	+	CCONJ
admet-292	1595	14	75	75	NUM
admet-292	1595	15	%	%	NOUN
admet-292	1595	16	sedimentation	sedimentation	NOUN
admet-292	1595	17	timing	timing	NOUN
admet-292	1595	18	protocol	protocol	NOUN
admet-292	1595	19	(	(	PUNCT
admet-292	1595	20	baka	baka	PROPN
admet-292	1595	21	et	et	PROPN
admet-292	1595	22	al	al	PROPN
admet-292	1595	23	.	.	PUNCT
admet-292	1596	1	j.	j.	PROPN
admet-292	1596	2	pharm	pharm	PROPN
admet-292	1596	3	.	.	PUNCT
admet-292	1596	4	biomed	biome	VERB
admet-292	1596	5	.	.	PUNCT
admet-292	1597	1	anal	anal	PROPN
admet-292	1597	2	.	.	PUNCT
admet-292	1598	1	2008	2008	NUM
admet-292	1598	2	,	,	PUNCT
admet-292	1598	3	46	46	NUM
admet-292	1598	4	,	,	PUNCT
admet-292	1598	5	335	335	NUM
admet-292	1598	6	-	-	SYM
admet-292	1598	7	341	341	NUM
admet-292	1598	8	)	)	PUNCT
admet-292	1598	9	is	be	AUX
admet-292	1598	10	recommended	recommend	VERB
admet-292	1598	11	.	.	PUNCT
admet-292	1599	1	stopping	stop	VERB
admet-292	1599	2	the	the	DET
admet-292	1599	3	stirring	stirring	NOUN
admet-292	1599	4	and	and	CCONJ
admet-292	1599	5	allowing	allow	VERB
admet-292	1599	6	the	the	DET
admet-292	1599	7	solid	solid	ADJ
admet-292	1599	8	to	to	ADP
admet-292	1599	9	sediment	sediment	NOUN
admet-292	1599	10	contributes	contribute	VERB
admet-292	1599	11	to	to	ADP
admet-292	1599	12	formation	formation	NOUN
admet-292	1599	13	of	of	ADP
admet-292	1599	14	better	well	ADJ
admet-292	1599	15	quality	quality	NOUN
admet-292	1599	16	crystals	crystal	NOUN
admet-292	1599	17	,	,	PUNCT
admet-292	1599	18	consistent	consistent	ADJ
admet-292	1599	19	with	with	ADP
admet-292	1599	20	a	a	DET
admet-292	1599	21	truly	truly	ADV
admet-292	1599	22	equilibrated	equilibrate	VERB
admet-292	1599	23	solution	solution	NOUN
admet-292	1599	24	.	.	PUNCT
admet-292	1600	1	admet	admet	PROPN
admet-292	1600	2	&	&	CCONJ
admet-292	1600	3	dmpk	dmpk	PROPN
admet-292	1600	4	4(2	4(2	NUM
admet-292	1600	5	)	)	PUNCT
admet-292	1600	6	(	(	PUNCT
admet-292	1600	7	2016	2016	NUM
admet-292	1600	8	)	)	PUNCT
admet-292	1600	9	117	117	NUM
admet-292	1600	10	-	-	SYM
admet-292	1600	11	178	178	NUM
admet-292	1600	12	consensus	consensus	NOUN
admet-292	1600	13	recommendations	recommendation	NOUN
admet-292	1600	14	for	for	ADP
admet-292	1600	15	improving	improve	VERB
admet-292	1600	16	solubility	solubility	NOUN
admet-292	1600	17	-	-	PUNCT
admet-292	1600	18	ph	ph	ADJ
admet-292	1600	19	data	datum	NOUN
admet-292	1600	20	quality	quality	NOUN
admet-292	1600	21	doi	doi	NOUN
admet-292	1600	22	:	:	PUNCT
admet-292	1600	23	10.5599	10.5599	NUM
admet-292	1600	24	/	/	SYM
admet-292	1600	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1600	26	171	171	NUM
admet-292	1600	27	“	"	PUNCT
admet-292	1600	28	it	it	PRON
admet-292	1600	29	could	could	AUX
admet-292	1600	30	be	be	AUX
admet-292	1600	31	a	a	DET
admet-292	1600	32	different	different	ADJ
admet-292	1600	33	ratio	ratio	NOUN
admet-292	1600	34	.	.	PUNCT
admet-292	1600	35	”	"	PUNCT
admet-292	1601	1	[	[	X
admet-292	1601	2	5yes	5yes	NUM
admet-292	1601	3	,	,	PUNCT
admet-292	1601	4	3	3	NUM
admet-292	1601	5	?	?	NUM
admet-292	1601	6	,	,	PUNCT
admet-292	1601	7	2no	2no	NOUN
admet-292	1601	8	]	]	X
admet-292	1601	9	in	in	ADP
admet-292	1601	10	regions	region	NOUN
admet-292	1601	11	of	of	ADP
admet-292	1601	12	ph	ph	NOUN
admet-292	1601	13	near	near	ADP
admet-292	1601	14	the	the	DET
admet-292	1601	15	pka	pka	PROPN
admet-292	1601	16	gibbs	gibbs	PROPN
admet-292	1601	17	(	(	PUNCT
admet-292	1601	18	sometimes	sometimes	ADV
admet-292	1601	19	called	call	VERB
admet-292	1601	20	‘	'	PUNCT
admet-292	1601	21	phmax	phmax	ADJ
admet-292	1601	22	’	'	PUNCT
admet-292	1601	23	)	)	PUNCT
admet-292	1601	24	,	,	PUNCT
admet-292	1601	25	where	where	SCONJ
admet-292	1601	26	the	the	DET
admet-292	1601	27	salt	salt	NOUN
admet-292	1601	28	form	form	NOUN
admet-292	1601	29	plus	plus	CCONJ
admet-292	1601	30	the	the	DET
admet-292	1601	31	uncharged	uncharged	ADJ
admet-292	1601	32	form	form	NOUN
admet-292	1601	33	of	of	ADP
admet-292	1601	34	the	the	DET
admet-292	1601	35	drug	drug	NOUN
admet-292	1601	36	co	co	NOUN
admet-292	1601	37	-	-	NOUN
admet-292	1601	38	precipitate	precipitate	ADJ
admet-292	1601	39	(	(	PUNCT
admet-292	1601	40	e.g.	e.g.	ADV
admet-292	1601	41	,	,	PUNCT
admet-292	1601	42	serajuddin	serajuddin	NOUN
admet-292	1601	43	and	and	CCONJ
admet-292	1601	44	rosoff	rosoff	NOUN
admet-292	1601	45	1984	1984	NUM
admet-292	1601	46	;	;	PUNCT
admet-292	1601	47	serajuddin	serajuddin	VERB
admet-292	1601	48	and	and	CCONJ
admet-292	1601	49	jarowski	jarowski	NOUN
admet-292	1601	50	1984	1984	NUM
admet-292	1601	51	,	,	PUNCT
admet-292	1601	52	1985	1985	NUM
admet-292	1601	53	,	,	PUNCT
admet-292	1601	54	1993	1993	NUM
admet-292	1601	55	)	)	PUNCT
admet-292	1601	56	,	,	PUNCT
admet-292	1601	57	longer	long	ADJ
admet-292	1601	58	equilibration	equilibration	NOUN
admet-292	1601	59	times	time	NOUN
admet-292	1601	60	(	(	PUNCT
admet-292	1601	61	e.g.	e.g.	ADV
admet-292	1601	62	,	,	PUNCT
admet-292	1601	63	24	24	NUM
admet-292	1601	64	]	]	SYM
admet-292	1601	65	-48	-48	CCONJ
admet-292	1601	66	h	h	NOUN
admet-292	1601	67	)	)	PUNCT
admet-292	1601	68	may	may	AUX
admet-292	1601	69	be	be	AUX
admet-292	1601	70	necessary	necessary	ADJ
admet-292	1601	71	due	due	ADP
admet-292	1601	72	to	to	ADP
admet-292	1601	73	the	the	DET
admet-292	1601	74	tendency	tendency	NOUN
admet-292	1601	75	of	of	ADP
admet-292	1601	76	the	the	DET
admet-292	1601	77	solutions	solution	NOUN
admet-292	1601	78	becoming	become	VERB
admet-292	1601	79	supersaturated	supersaturated	ADJ
admet-292	1601	80	.	.	PUNCT
admet-292	1602	1	[	[	X
admet-292	1602	2	3yes	3yes	NUM
admet-292	1602	3	,	,	PUNCT
admet-292	1602	4	4	4	NUM
admet-292	1602	5	?	?	NUM
admet-292	1602	6	,	,	PUNCT
admet-292	1602	7	3no	3no	ADJ
admet-292	1602	8	]	]	PUNCT
admet-292	1602	9	for	for	ADP
admet-292	1602	10	some	some	DET
admet-292	1602	11	kinds	kind	NOUN
admet-292	1602	12	of	of	ADP
admet-292	1602	13	drug	drug	NOUN
admet-292	1602	14	(	(	PUNCT
admet-292	1602	15	e.g	e.g	NOUN
admet-292	1602	16	,	,	PUNCT
admet-292	1602	17	phenothiazines	phenothiazine	NOUN
admet-292	1602	18	)	)	PUNCT
admet-292	1602	19	,	,	PUNCT
admet-292	1602	20	at	at	ADP
admet-292	1602	21	temperatures	temperature	NOUN
admet-292	1602	22	above	above	ADP
admet-292	1602	23	the	the	DET
admet-292	1602	24	krafft	krafft	PROPN
admet-292	1602	25	point	point	NOUN
admet-292	1602	26	,	,	PUNCT
admet-292	1602	27	the	the	DET
admet-292	1602	28	solid	solid	NOUN
admet-292	1602	29	may	may	AUX
admet-292	1602	30	dissolve	dissolve	VERB
admet-292	1602	31	directly	directly	ADV
admet-292	1602	32	into	into	ADP
admet-292	1602	33	a	a	DET
admet-292	1602	34	micellar	micellar	NOUN
admet-292	1602	35	or	or	CCONJ
admet-292	1602	36	a	a	DET
admet-292	1602	37	highly	highly	ADV
admet-292	1602	38	supersaturated	supersaturated	ADJ
admet-292	1602	39	form	form	NOUN
admet-292	1602	40	,	,	PUNCT
admet-292	1602	41	which	which	PRON
admet-292	1602	42	may	may	AUX
admet-292	1602	43	,	,	PUNCT
admet-292	1602	44	in	in	ADP
admet-292	1602	45	turn	turn	NOUN
admet-292	1602	46	,	,	PUNCT
admet-292	1602	47	transition	transition	NOUN
admet-292	1602	48	into	into	ADP
admet-292	1602	49	an	an	DET
admet-292	1602	50	oil	oil	NOUN
admet-292	1602	51	(	(	PUNCT
admet-292	1602	52	depending	depend	VERB
admet-292	1602	53	on	on	ADP
admet-292	1602	54	ph	ph	NOUN
admet-292	1602	55	)	)	PUNCT
admet-292	1602	56	,	,	PUNCT
admet-292	1602	57	longer	long	ADJ
admet-292	1602	58	equilibration	equilibration	NOUN
admet-292	1602	59	times	time	NOUN
admet-292	1602	60	(	(	PUNCT
admet-292	1602	61	e.g.	e.g.	ADV
admet-292	1602	62	,	,	PUNCT
admet-292	1602	63	48	48	NUM
admet-292	1602	64	-	-	SYM
admet-292	1602	65	72	72	NUM
admet-292	1602	66	h	h	NOUN
admet-292	1602	67	)	)	PUNCT
admet-292	1602	68	may	may	AUX
admet-292	1602	69	be	be	AUX
admet-292	1602	70	necessary	necessary	ADJ
admet-292	1602	71	if	if	SCONJ
admet-292	1602	72	equilibrium	equilibrium	NOUN
admet-292	1602	73	solubility	solubility	NOUN
admet-292	1602	74	is	be	AUX
admet-292	1602	75	to	to	PART
admet-292	1602	76	be	be	AUX
admet-292	1602	77	measured	measure	VERB
admet-292	1602	78	.	.	PUNCT
admet-292	1603	1	“	"	PUNCT
admet-292	1603	2	these	these	DET
admet-292	1603	3	kinds	kind	NOUN
admet-292	1603	4	of	of	ADP
admet-292	1603	5	compounds	compound	NOUN
admet-292	1603	6	may	may	AUX
admet-292	1603	7	go	go	VERB
admet-292	1603	8	through	through	ADP
admet-292	1603	9	liquid	liquid	NOUN
admet-292	1603	10	-	-	PUNCT
admet-292	1603	11	liquid	liquid	ADJ
admet-292	1603	12	phase	phase	NOUN
admet-292	1603	13	separation	separation	NOUN
admet-292	1603	14	and	and	CCONJ
admet-292	1603	15	additional	additional	ADJ
admet-292	1603	16	equilibration	equilibration	NOUN
admet-292	1603	17	time	time	NOUN
admet-292	1603	18	will	will	AUX
admet-292	1603	19	not	not	PART
admet-292	1603	20	lead	lead	VERB
admet-292	1603	21	to	to	ADP
admet-292	1603	22	solid	solid	ADJ
admet-292	1603	23	form	form	NOUN
admet-292	1603	24	precipitation	precipitation	NOUN
admet-292	1603	25	.	.	PUNCT
admet-292	1603	26	“	"	PUNCT
admet-292	1604	1	[	[	X
admet-292	1604	2	3yes	3yes	NUM
admet-292	1604	3	,	,	PUNCT
admet-292	1604	4	3	3	NUM
admet-292	1604	5	?	?	NUM
admet-292	1604	6	,	,	PUNCT
admet-292	1604	7	4no	4no	NOUN
admet-292	1604	8	]	]	PUNCT
admet-292	1604	9	equilibration	equilibration	NOUN
admet-292	1604	10	times	time	NOUN
admet-292	1604	11	as	as	ADV
admet-292	1604	12	long	long	ADV
admet-292	1604	13	as	as	ADP
admet-292	1604	14	many	many	ADJ
admet-292	1604	15	days	day	NOUN
admet-292	1604	16	have	have	AUX
admet-292	1604	17	been	be	AUX
admet-292	1604	18	used	use	VERB
admet-292	1604	19	.	.	PUNCT
admet-292	1605	1	ordinarily	ordinarily	ADV
admet-292	1605	2	,	,	PUNCT
admet-292	1605	3	long	long	ADJ
admet-292	1605	4	times	time	NOUN
admet-292	1605	5	are	be	AUX
admet-292	1605	6	not	not	PART
admet-292	1605	7	recommended	recommend	VERB
admet-292	1605	8	,	,	PUNCT
admet-292	1605	9	unless	unless	SCONJ
admet-292	1605	10	one	one	NUM
admet-292	1605	11	is	be	AUX
admet-292	1605	12	interested	interested	ADJ
admet-292	1605	13	to	to	PART
admet-292	1605	14	determine	determine	VERB
admet-292	1605	15	the	the	DET
admet-292	1605	16	solubility	solubility	NOUN
admet-292	1605	17	enhancement	enhancement	NOUN
admet-292	1605	18	of	of	ADP
admet-292	1605	19	a	a	DET
admet-292	1605	20	biorelevant	biorelevant	ADJ
admet-292	1605	21	medium	medium	ADJ
admet-292	1605	22	or	or	CCONJ
admet-292	1605	23	human	human	ADJ
admet-292	1605	24	intestinal	intestinal	ADJ
admet-292	1605	25	fluid	fluid	NOUN
admet-292	1605	26	.	.	PUNCT
admet-292	1606	1	“	"	PUNCT
admet-292	1606	2	long	long	ADJ
admet-292	1606	3	times	time	NOUN
admet-292	1606	4	can	can	AUX
admet-292	1606	5	be	be	AUX
admet-292	1606	6	helpful	helpful	ADJ
admet-292	1606	7	to	to	PART
admet-292	1606	8	follow	follow	VERB
admet-292	1606	9	re	re	NOUN
admet-292	1606	10	-	-	NOUN
admet-292	1606	11	crystallization	crystallization	NOUN
admet-292	1606	12	of	of	ADP
admet-292	1606	13	alternative	alternative	ADJ
admet-292	1606	14	solid	solid	ADJ
admet-292	1606	15	forms	form	NOUN
admet-292	1606	16	.	.	PUNCT
admet-292	1606	17	”	"	PUNCT
admet-292	1607	1	“	"	PUNCT
admet-292	1607	2	equil	equil	PROPN
admet-292	1607	3	.	.	PUNCT
admet-292	1607	4	time	time	NOUN
admet-292	1607	5	should	should	AUX
admet-292	1607	6	be	be	AUX
admet-292	1607	7	as	as	ADV
admet-292	1607	8	long	long	ADJ
admet-292	1607	9	as	as	ADP
admet-292	1607	10	necessary	necessary	ADJ
admet-292	1607	11	to	to	PART
admet-292	1607	12	provide	provide	VERB
admet-292	1607	13	precipitation	precipitation	NOUN
admet-292	1607	14	of	of	ADP
admet-292	1607	15	the	the	DET
admet-292	1607	16	most	most	ADV
admet-292	1607	17	stable	stable	ADJ
admet-292	1607	18	polymorph	polymorph	NOUN
admet-292	1607	19	.	.	PUNCT
admet-292	1607	20	”	"	PUNCT
admet-292	1608	1	shortening	shorten	VERB
admet-292	1608	2	the	the	DET
admet-292	1608	3	equilibration	equilibration	NOUN
admet-292	1608	4	time	time	NOUN
admet-292	1609	1	[	[	X
admet-292	1609	2	2yes	2ye	NOUN
admet-292	1609	3	,	,	PUNCT
admet-292	1609	4	3	3	NUM
admet-292	1609	5	?	?	NUM
admet-292	1609	6	,	,	PUNCT
admet-292	1609	7	5no	5no	NOUN
admet-292	1609	8	]	]	X
admet-292	1609	9	if	if	SCONJ
admet-292	1609	10	the	the	DET
admet-292	1609	11	initial	initial	ADJ
admet-292	1609	12	solid	solid	ADJ
admet-292	1609	13	form	form	NOUN
admet-292	1609	14	of	of	ADP
admet-292	1609	15	the	the	DET
admet-292	1609	16	drug	drug	NOUN
admet-292	1609	17	is	be	AUX
admet-292	1609	18	unknown	unknown	ADJ
admet-292	1609	19	,	,	PUNCT
admet-292	1609	20	dissolve	dissolve	VERB
admet-292	1609	21	the	the	DET
admet-292	1609	22	crystals	crystal	NOUN
admet-292	1609	23	in	in	ADP
admet-292	1609	24	the	the	DET
admet-292	1609	25	assay	assay	NOUN
admet-292	1609	26	vial	vial	NOUN
admet-292	1609	27	with	with	ADP
admet-292	1609	28	a	a	DET
admet-292	1609	29	drop	drop	NOUN
admet-292	1609	30	or	or	CCONJ
admet-292	1609	31	two	two	NUM
admet-292	1609	32	of	of	ADP
admet-292	1609	33	methanol	methanol	NOUN
admet-292	1609	34	(	(	PUNCT
admet-292	1609	35	or	or	CCONJ
admet-292	1609	36	another	another	DET
admet-292	1609	37	volatile	volatile	ADJ
admet-292	1609	38	organic	organic	ADJ
admet-292	1609	39	solvent	solvent	NOUN
admet-292	1609	40	in	in	ADP
admet-292	1609	41	which	which	PRON
admet-292	1609	42	the	the	DET
admet-292	1609	43	crystals	crystal	NOUN
admet-292	1609	44	dissolve	dissolve	VERB
admet-292	1609	45	)	)	PUNCT
admet-292	1609	46	.	.	PUNCT
admet-292	1610	1	swirl	swirl	VERB
admet-292	1610	2	the	the	DET
admet-292	1610	3	vial	vial	NOUN
admet-292	1610	4	to	to	PART
admet-292	1610	5	let	let	VERB
admet-292	1610	6	the	the	DET
admet-292	1610	7	methanol	methanol	NOUN
admet-292	1610	8	evaporate	evaporate	VERB
admet-292	1610	9	before	before	ADP
admet-292	1610	10	adding	add	VERB
admet-292	1610	11	the	the	DET
admet-292	1610	12	solution	solution	NOUN
admet-292	1610	13	medium	medium	NOUN
admet-292	1610	14	.	.	PUNCT
admet-292	1611	1	usually	usually	ADV
admet-292	1611	2	the	the	DET
admet-292	1611	3	freshly	freshly	ADV
admet-292	1611	4	-	-	PUNCT
admet-292	1611	5	formed	form	VERB
admet-292	1611	6	crystals	crystal	NOUN
admet-292	1611	7	wet	wet	ADJ
admet-292	1611	8	better	well	ADV
admet-292	1611	9	and	and	CCONJ
admet-292	1611	10	dissolve	dissolve	VERB
admet-292	1611	11	quickly	quickly	ADV
admet-292	1611	12	.	.	PUNCT
admet-292	1612	1	this	this	DET
admet-292	1612	2	procedure	procedure	NOUN
admet-292	1612	3	is	be	AUX
admet-292	1612	4	often	often	ADV
admet-292	1612	5	used	use	VERB
admet-292	1612	6	in	in	ADP
admet-292	1612	7	the	the	DET
admet-292	1612	8	dtt	dtt	NOUN
admet-292	1612	9	method	method	NOUN
admet-292	1612	10	.	.	PUNCT
admet-292	1613	1	“	"	PUNCT
admet-292	1613	2	the	the	DET
admet-292	1613	3	choice	choice	NOUN
admet-292	1613	4	of	of	ADP
admet-292	1613	5	solvent	solvent	NOUN
admet-292	1613	6	depends	depend	VERB
admet-292	1613	7	on	on	ADP
admet-292	1613	8	the	the	DET
admet-292	1613	9	substance	substance	NOUN
admet-292	1613	10	.	.	PUNCT
admet-292	1613	11	”	"	PUNCT
admet-292	1614	1	“	"	PUNCT
admet-292	1614	2	suitable	suitable	ADJ
admet-292	1614	3	for	for	ADP
admet-292	1614	4	selection	selection	NOUN
admet-292	1614	5	study	study	NOUN
admet-292	1614	6	of	of	ADP
admet-292	1614	7	only	only	ADJ
admet-292	1614	8	candidate	candidate	NOUN
admet-292	1614	9	.	.	PUNCT
admet-292	1614	10	”	"	PUNCT
admet-292	1615	1	[	[	X
admet-292	1615	2	4yes	4ye	NOUN
admet-292	1615	3	,	,	PUNCT
admet-292	1615	4	3	3	NUM
admet-292	1615	5	?	?	NUM
admet-292	1615	6	,	,	PUNCT
admet-292	1615	7	3no	3no	NOUN
admet-292	1615	8	]	]	PUNCT
admet-292	1615	9	if	if	SCONJ
admet-292	1615	10	the	the	DET
admet-292	1615	11	initial	initial	ADJ
admet-292	1615	12	solid	solid	ADJ
admet-292	1615	13	form	form	NOUN
admet-292	1615	14	of	of	ADP
admet-292	1615	15	the	the	DET
admet-292	1615	16	drug	drug	NOUN
admet-292	1615	17	is	be	AUX
admet-292	1615	18	unknown	unknown	ADJ
admet-292	1615	19	,	,	PUNCT
admet-292	1615	20	add	add	VERB
admet-292	1615	21	the	the	DET
admet-292	1615	22	crystals	crystal	NOUN
admet-292	1615	23	to	to	ADP
admet-292	1615	24	the	the	DET
admet-292	1615	25	buffer	buffer	NOUN
admet-292	1615	26	solution	solution	NOUN
admet-292	1615	27	.	.	PUNCT
admet-292	1616	1	for	for	ADP
admet-292	1616	2	a	a	DET
admet-292	1616	3	weak	weak	ADJ
admet-292	1616	4	acid	acid	NOUN
admet-292	1616	5	/	/	SYM
admet-292	1616	6	base	base	NOUN
admet-292	1616	7	drug	drug	NOUN
admet-292	1616	8	,	,	PUNCT
admet-292	1616	9	add	add	VERB
admet-292	1616	10	a	a	DET
admet-292	1616	11	known	know	VERB
admet-292	1616	12	amount	amount	NOUN
admet-292	1616	13	of	of	ADP
admet-292	1616	14	standardized	standardized	ADJ
admet-292	1616	15	base	base	NOUN
admet-292	1616	16	/	/	SYM
admet-292	1616	17	acid	acid	NOUN
admet-292	1616	18	titrant	titrant	NOUN
admet-292	1616	19	to	to	PART
admet-292	1616	20	dissolve	dissolve	VERB
admet-292	1616	21	the	the	DET
admet-292	1616	22	solid	solid	NOUN
admet-292	1616	23	,	,	PUNCT
admet-292	1616	24	but	but	CCONJ
admet-292	1616	25	avoid	avoid	VERB
admet-292	1616	26	extremes	extreme	NOUN
admet-292	1616	27	of	of	ADP
admet-292	1616	28	ph	ph	VERB
admet-292	1616	29	.	.	PROPN
admet-292	1616	30	quickly	quickly	ADV
admet-292	1616	31	add	add	VERB
admet-292	1616	32	a	a	DET
admet-292	1616	33	known	know	VERB
admet-292	1616	34	amount	amount	NOUN
admet-292	1616	35	of	of	ADP
admet-292	1616	36	standardized	standardized	ADJ
admet-292	1616	37	counter	counter	NOUN
admet-292	1616	38	titrant	titrant	NOUN
admet-292	1616	39	to	to	ADP
admet-292	1616	40	the	the	DET
admet-292	1616	41	desired	desire	VERB
admet-292	1616	42	starting	starting	NOUN
admet-292	1616	43	ph	ph	PROPN
admet-292	1616	44	.	.	PUNCT
admet-292	1617	1	a	a	DET
admet-292	1617	2	procedure	procedure	NOUN
admet-292	1617	3	like	like	ADP
admet-292	1617	4	this	this	PRON
admet-292	1617	5	is	be	AUX
admet-292	1617	6	used	use	VERB
admet-292	1617	7	in	in	ADP
admet-292	1617	8	the	the	DET
admet-292	1617	9	cheqsol	cheqsol	ADJ
admet-292	1617	10	method	method	NOUN
admet-292	1617	11	,	,	PUNCT
admet-292	1617	12	with	with	ADP
admet-292	1617	13	repeated	repeat	VERB
admet-292	1617	14	cycles	cycle	NOUN
admet-292	1617	15	of	of	ADP
admet-292	1617	16	dissolution	dissolution	NOUN
admet-292	1617	17	and	and	CCONJ
admet-292	1617	18	re	re	NOUN
admet-292	1617	19	-	-	NOUN
admet-292	1617	20	precipitation	precipitation	NOUN
admet-292	1617	21	by	by	ADP
admet-292	1617	22	ph	ph	ADJ
admet-292	1617	23	adjustment	adjustment	NOUN
admet-292	1617	24	.	.	PUNCT
admet-292	1618	1	“	"	PUNCT
admet-292	1618	2	method	method	VERB
admet-292	1618	3	suitable	suitable	ADJ
admet-292	1618	4	for	for	ADP
admet-292	1618	5	fast	fast	ADJ
admet-292	1618	6	solubility	solubility	NOUN
admet-292	1618	7	determination	determination	NOUN
admet-292	1618	8	.	.	PUNCT
admet-292	1618	9	”	"	PUNCT
admet-292	1619	1	[	[	X
admet-292	1619	2	2yes,5?,3no	2yes,5?,3no	NOUN
admet-292	1619	3	]	]	X
admet-292	1619	4	the	the	DET
admet-292	1619	5	loftsson	loftsson	NOUN
admet-292	1619	6	et	et	PROPN
admet-292	1619	7	al	al	PROPN
admet-292	1619	8	.	.	PUNCT
admet-292	1620	1	(	(	PUNCT
admet-292	1620	2	int	int	NOUN
admet-292	1620	3	.	.	PUNCT
admet-292	1621	1	j.	j.	PROPN
admet-292	1621	2	pharm	pharm	PROPN
admet-292	1621	3	.	.	PUNCT
admet-292	1622	1	2005	2005	NUM
admet-292	1622	2	,	,	PUNCT
admet-292	1622	3	302	302	NUM
admet-292	1622	4	,	,	PUNCT
admet-292	1622	5	18–28	18–28	NUM
admet-292	1622	6	)	)	PUNCT
admet-292	1622	7	temperature	temperature	NOUN
admet-292	1622	8	spiking	spike	VERB
admet-292	1622	9	cycles	cycle	NOUN
admet-292	1622	10	and	and	CCONJ
admet-292	1622	11	seed	seed	NOUN
admet-292	1622	12	crystal	crystal	NOUN
admet-292	1622	13	may	may	AUX
admet-292	1622	14	be	be	AUX
admet-292	1622	15	used	use	VERB
admet-292	1622	16	to	to	PART
admet-292	1622	17	shorten	shorten	VERB
admet-292	1622	18	the	the	DET
admet-292	1622	19	equilibration	equilibration	NOUN
admet-292	1622	20	time	time	NOUN
admet-292	1622	21	.	.	PUNCT
admet-292	1623	1	“	"	PUNCT
admet-292	1623	2	careful	careful	ADJ
admet-292	1623	3	analysis	analysis	NOUN
admet-292	1623	4	of	of	ADP
admet-292	1623	5	the	the	DET
admet-292	1623	6	solid	solid	ADJ
admet-292	1623	7	phase	phase	NOUN
admet-292	1623	8	and	and	CCONJ
admet-292	1623	9	microscopy	microscopy	NOUN
admet-292	1623	10	observations	observation	NOUN
admet-292	1623	11	are	be	AUX
admet-292	1623	12	needed	need	VERB
admet-292	1623	13	for	for	ADP
admet-292	1623	14	correct	correct	ADJ
admet-292	1623	15	interpretation	interpretation	NOUN
admet-292	1623	16	of	of	ADP
admet-292	1623	17	results	result	NOUN
admet-292	1623	18	.	.	PUNCT
admet-292	1623	19	”	"	PUNCT
admet-292	1624	1	[	[	X
admet-292	1624	2	1yes	1ye	NOUN
admet-292	1624	3	,	,	PUNCT
admet-292	1624	4	6	6	NUM
admet-292	1624	5	?	?	NUM
admet-292	1624	6	,	,	PUNCT
admet-292	1624	7	3no	3no	ADJ
admet-292	1624	8	]	]	PUNCT
admet-292	1624	9	the	the	DET
admet-292	1624	10	facilitated	facilitate	VERB
admet-292	1624	11	dissolution	dissolution	NOUN
admet-292	1624	12	method	method	NOUN
admet-292	1624	13	of	of	ADP
admet-292	1624	14	higuchi	higuchi	PROPN
admet-292	1624	15	(	(	PUNCT
admet-292	1624	16	cf	cf	NOUN
admet-292	1624	17	.	.	PUNCT
admet-292	1624	18	,	,	PUNCT
admet-292	1624	19	avdeef	avdeef	VERB
admet-292	1624	20	[	[	X
admet-292	1624	21	4	4	NUM
admet-292	1624	22	]	]	NUM
admet-292	1624	23	)	)	PUNCT
admet-292	1624	24	,	,	PUNCT
admet-292	1624	25	consisting	consist	VERB
admet-292	1624	26	of	of	ADP
admet-292	1624	27	adding	add	VERB
admet-292	1624	28	a	a	DET
admet-292	1624	29	drop	drop	NOUN
admet-292	1624	30	of	of	ADP
admet-292	1624	31	water	water	NOUN
admet-292	1624	32	-	-	PUNCT
admet-292	1624	33	immiscible	immiscible	ADJ
admet-292	1624	34	oil	oil	NOUN
admet-292	1624	35	to	to	ADP
admet-292	1624	36	the	the	DET
admet-292	1624	37	solution	solution	NOUN
admet-292	1624	38	medium	medium	NOUN
admet-292	1624	39	,	,	PUNCT
admet-292	1624	40	may	may	AUX
admet-292	1624	41	be	be	AUX
admet-292	1624	42	used	use	VERB
admet-292	1624	43	to	to	PART
admet-292	1624	44	speed	speed	VERB
admet-292	1624	45	up	up	ADP
admet-292	1624	46	the	the	DET
admet-292	1624	47	rate	rate	NOUN
admet-292	1624	48	of	of	ADP
admet-292	1624	49	equilibration	equilibration	NOUN
admet-292	1624	50	.	.	PUNCT
admet-292	1625	1	the	the	DET
admet-292	1625	2	method	method	NOUN
admet-292	1625	3	is	be	AUX
admet-292	1625	4	alex	alex	PROPN
admet-292	1625	5	avdeef	avdeef	PROPN
admet-292	1625	6	et	et	PROPN
admet-292	1625	7	al	al	PROPN
admet-292	1625	8	.	.	PROPN
admet-292	1625	9	admet	admet	PROPN
admet-292	1625	10	&	&	CCONJ
admet-292	1625	11	dmpk	dmpk	PROPN
admet-292	1625	12	4(2	4(2	NUM
admet-292	1625	13	)	)	PUNCT
admet-292	1625	14	(	(	PUNCT
admet-292	1625	15	2016	2016	NUM
admet-292	1625	16	)	)	PUNCT
admet-292	1625	17	117	117	NUM
admet-292	1625	18	-	-	SYM
admet-292	1625	19	178	178	NUM
admet-292	1625	20	172	172	NUM
admet-292	1625	21	fundamentally	fundamentally	ADV
admet-292	1625	22	rigorous	rigorous	ADJ
admet-292	1625	23	and	and	CCONJ
admet-292	1625	24	deserved	deserve	VERB
admet-292	1625	25	much	much	ADV
admet-292	1625	26	more	more	ADJ
admet-292	1625	27	attention	attention	NOUN
admet-292	1625	28	than	than	SCONJ
admet-292	1625	29	it	it	PRON
admet-292	1625	30	has	have	AUX
admet-292	1625	31	received	receive	VERB
admet-292	1625	32	,	,	PUNCT
admet-292	1625	33	including	include	VERB
admet-292	1625	34	validation	validation	NOUN
admet-292	1625	35	studies	study	NOUN
admet-292	1625	36	.	.	PUNCT
admet-292	1626	1	“	"	PUNCT
admet-292	1626	2	this	this	PRON
admet-292	1626	3	is	be	AUX
admet-292	1626	4	an	an	DET
admet-292	1626	5	interesting	interesting	ADJ
admet-292	1626	6	approach	approach	NOUN
admet-292	1626	7	that	that	PRON
admet-292	1626	8	have	have	AUX
admet-292	1626	9	not	not	PART
admet-292	1626	10	been	be	AUX
admet-292	1626	11	much	much	ADV
admet-292	1626	12	appreciated	appreciated	ADJ
admet-292	1626	13	.	.	PUNCT
admet-292	1627	1	we	we	PRON
admet-292	1627	2	’d	’d	AUX
admet-292	1627	3	love	love	VERB
admet-292	1627	4	to	to	PART
admet-292	1627	5	try	try	VERB
admet-292	1627	6	it	it	PRON
admet-292	1627	7	out	out	ADP
admet-292	1627	8	.	.	PUNCT
admet-292	1627	9	”	"	PUNCT
admet-292	1628	1	[	[	X
admet-292	1628	2	1yes	1ye	NOUN
admet-292	1628	3	,	,	PUNCT
admet-292	1628	4	8	8	NUM
admet-292	1628	5	?	?	SYM
admet-292	1628	6	,	,	PUNCT
admet-292	1628	7	1no	1no	NOUN
admet-292	1628	8	]	]	X
admet-292	1628	9	most	most	ADJ
admet-292	1628	10	of	of	ADP
admet-292	1628	11	the	the	DET
admet-292	1628	12	above	above	ADJ
admet-292	1628	13	methods	method	NOUN
admet-292	1628	14	look	look	VERB
admet-292	1628	15	promising	promise	VERB
admet-292	1628	16	.	.	PUNCT
admet-292	1629	1	solution	solution	NOUN
admet-292	1629	2	and	and	CCONJ
admet-292	1629	3	solid	solid	ADJ
admet-292	1629	4	state	state	NOUN
admet-292	1629	5	composition	composition	NOUN
admet-292	1629	6	[	[	X
admet-292	1629	7	9yes	9yes	NUM
admet-292	1629	8	,	,	PUNCT
admet-292	1629	9	1no	1no	ADJ
admet-292	1629	10	]	]	X
admet-292	1630	1	it	it	PRON
admet-292	1630	2	is	be	AUX
admet-292	1630	3	a	a	DET
admet-292	1630	4	good	good	ADJ
admet-292	1630	5	idea	idea	NOUN
admet-292	1630	6	to	to	PART
admet-292	1630	7	keep	keep	VERB
admet-292	1630	8	the	the	DET
admet-292	1630	9	assay	assay	NOUN
admet-292	1630	10	solutions	solution	NOUN
admet-292	1630	11	simple	simple	ADJ
admet-292	1630	12	and	and	CCONJ
admet-292	1630	13	to	to	PART
admet-292	1630	14	define	define	VERB
admet-292	1630	15	all	all	DET
admet-292	1630	16	components	component	NOUN
admet-292	1630	17	precisely	precisely	ADV
admet-292	1630	18	.	.	PUNCT
admet-292	1631	1	report	report	VERB
admet-292	1631	2	the	the	DET
admet-292	1631	3	state	state	NOUN
admet-292	1631	4	of	of	ADP
admet-292	1631	5	the	the	DET
admet-292	1631	6	solid	solid	ADJ
admet-292	1631	7	,	,	PUNCT
admet-292	1631	8	if	if	SCONJ
admet-292	1631	9	known	know	VERB
admet-292	1631	10	(	(	PUNCT
admet-292	1631	11	e.g.	e.g.	ADV
admet-292	1631	12	,	,	PUNCT
admet-292	1631	13	polymorphic	polymorphic	ADJ
admet-292	1631	14	,	,	PUNCT
admet-292	1631	15	hydrate	hydrate	ADJ
admet-292	1631	16	,	,	PUNCT
admet-292	1631	17	solvate	solvate	NOUN
admet-292	1631	18	,	,	PUNCT
admet-292	1631	19	amorphous	amorphous	ADJ
admet-292	1631	20	,	,	PUNCT
admet-292	1631	21	stereoisomer	stereoisomer	NOUN
admet-292	1631	22	)	)	PUNCT
admet-292	1631	23	.	.	PUNCT
admet-292	1632	1	“	"	PUNCT
admet-292	1632	2	it	it	PRON
admet-292	1632	3	is	be	AUX
admet-292	1632	4	a	a	DET
admet-292	1632	5	must	must	NOUN
admet-292	1632	6	to	to	PART
admet-292	1632	7	characterize	characterize	VERB
admet-292	1632	8	the	the	DET
admet-292	1632	9	solid	solid	ADJ
admet-292	1632	10	samples	sample	NOUN
admet-292	1632	11	as	as	ADV
admet-292	1632	12	detailed	detailed	ADJ
admet-292	1632	13	as	as	ADP
admet-292	1632	14	possible	possible	ADJ
admet-292	1632	15	(	(	PUNCT
admet-292	1632	16	structure	structure	NOUN
admet-292	1632	17	,	,	PUNCT
admet-292	1632	18	meso	meso	NOUN
admet-292	1632	19	-	-	PUNCT
admet-292	1632	20	structure	structure	NOUN
admet-292	1632	21	,	,	PUNCT
admet-292	1632	22	particle	particle	NOUN
admet-292	1632	23	size	size	NOUN
admet-292	1632	24	,	,	PUNCT
admet-292	1632	25	shape	shape	NOUN
admet-292	1632	26	,	,	PUNCT
admet-292	1632	27	surface	surface	NOUN
admet-292	1632	28	area	area	NOUN
admet-292	1632	29	,	,	PUNCT
admet-292	1632	30	etc	etc	X
admet-292	1632	31	.	.	X
admet-292	1632	32	)	)	PUNCT
admet-292	1632	33	,	,	PUNCT
admet-292	1632	34	also	also	ADV
admet-292	1632	35	in	in	ADP
admet-292	1632	36	the	the	DET
admet-292	1632	37	process	process	NOUN
admet-292	1632	38	of	of	ADP
admet-292	1632	39	dissolution	dissolution	ADJ
admet-292	1632	40	recrystallization	recrystallization	NOUN
admet-292	1632	41	.	.	PUNCT
admet-292	1632	42	”	"	PUNCT
admet-292	1633	1	“	"	PUNCT
admet-292	1633	2	time	time	NOUN
admet-292	1633	3	and	and	CCONJ
admet-292	1633	4	resource	resource	NOUN
admet-292	1633	5	consuming	consuming	NOUN
admet-292	1633	6	.	.	PUNCT
admet-292	1634	1	not	not	PART
admet-292	1634	2	be	be	AUX
admet-292	1634	3	used	use	VERB
admet-292	1634	4	for	for	ADP
admet-292	1634	5	selection	selection	NOUN
admet-292	1634	6	.	.	PUNCT
admet-292	1634	7	”	"	PUNCT
admet-292	1635	1	[	[	X
admet-292	1635	2	10yes	10yes	X
admet-292	1635	3	]	]	X
admet-292	1635	4	when	when	SCONJ
admet-292	1635	5	possible	possible	ADJ
admet-292	1635	6	,	,	PUNCT
admet-292	1635	7	it	it	PRON
admet-292	1635	8	is	be	AUX
admet-292	1635	9	a	a	DET
admet-292	1635	10	good	good	ADJ
admet-292	1635	11	idea	idea	NOUN
admet-292	1635	12	to	to	PART
admet-292	1635	13	do	do	AUX
admet-292	1635	14	solid	solid	ADJ
admet-292	1635	15	state	state	NOUN
admet-292	1635	16	characterization	characterization	NOUN
admet-292	1635	17	of	of	ADP
admet-292	1635	18	the	the	DET
admet-292	1635	19	precipitate	precipitate	NOUN
admet-292	1635	20	at	at	ADP
admet-292	1635	21	the	the	DET
admet-292	1635	22	end	end	NOUN
admet-292	1635	23	of	of	ADP
admet-292	1635	24	equilibration	equilibration	NOUN
admet-292	1635	25	,	,	PUNCT
admet-292	1635	26	to	to	PART
admet-292	1635	27	determine	determine	VERB
admet-292	1635	28	if	if	SCONJ
admet-292	1635	29	a	a	DET
admet-292	1635	30	solid	solid	ADJ
admet-292	1635	31	-	-	PUNCT
admet-292	1635	32	state	state	NOUN
admet-292	1635	33	transformation	transformation	NOUN
admet-292	1635	34	had	have	AUX
admet-292	1635	35	taken	take	VERB
admet-292	1635	36	place	place	NOUN
admet-292	1635	37	,	,	PUNCT
admet-292	1635	38	or	or	CCONJ
admet-292	1635	39	to	to	PART
admet-292	1635	40	confirm	confirm	VERB
admet-292	1635	41	the	the	DET
admet-292	1635	42	crystalline	crystalline	ADJ
admet-292	1635	43	nature	nature	NOUN
admet-292	1635	44	of	of	ADP
admet-292	1635	45	the	the	DET
admet-292	1635	46	solid	solid	ADJ
admet-292	1635	47	,	,	PUNCT
admet-292	1635	48	or	or	CCONJ
admet-292	1635	49	to	to	PART
admet-292	1635	50	ensure	ensure	VERB
admet-292	1635	51	that	that	SCONJ
admet-292	1635	52	a	a	DET
admet-292	1635	53	mixture	mixture	NOUN
admet-292	1635	54	of	of	ADP
admet-292	1635	55	solid	solid	ADJ
admet-292	1635	56	forms	form	NOUN
admet-292	1635	57	is	be	AUX
admet-292	1635	58	not	not	PART
admet-292	1635	59	present	present	ADJ
admet-292	1635	60	.	.	PUNCT
admet-292	1636	1	“	"	PUNCT
admet-292	1636	2	at	at	ADP
admet-292	1636	3	the	the	DET
admet-292	1636	4	beginning	beginning	NOUN
admet-292	1636	5	,	,	PUNCT
admet-292	1636	6	at	at	ADP
admet-292	1636	7	the	the	DET
admet-292	1636	8	end	end	NOUN
admet-292	1636	9	,	,	PUNCT
admet-292	1636	10	at	at	ADP
admet-292	1636	11	the	the	DET
admet-292	1636	12	intermediate	intermediate	ADJ
admet-292	1636	13	stages	stage	NOUN
admet-292	1636	14	;	;	PUNCT
admet-292	1636	15	“	"	PUNCT
admet-292	1636	16	unusual	unusual	ADJ
admet-292	1636	17	”	"	PUNCT
admet-292	1636	18	temperature	temperature	NOUN
admet-292	1636	19	dependence	dependence	NOUN
admet-292	1636	20	of	of	ADP
admet-292	1636	21	solubility	solubility	NOUN
admet-292	1636	22	also	also	ADV
admet-292	1636	23	suggests	suggest	VERB
admet-292	1636	24	a	a	DET
admet-292	1636	25	change	change	NOUN
admet-292	1636	26	in	in	ADP
admet-292	1636	27	the	the	DET
admet-292	1636	28	solid	solid	ADJ
admet-292	1636	29	form	form	NOUN
admet-292	1636	30	.	.	PUNCT
admet-292	1636	31	”	"	PUNCT
admet-292	1637	1	[	[	X
admet-292	1637	2	10yes	10yes	X
admet-292	1637	3	]	]	PUNCT
admet-292	1637	4	when	when	SCONJ
admet-292	1637	5	studying	study	VERB
admet-292	1637	6	salt	salt	NOUN
admet-292	1637	7	solubility	solubility	NOUN
admet-292	1637	8	,	,	PUNCT
admet-292	1637	9	it	it	PRON
admet-292	1637	10	is	be	AUX
admet-292	1637	11	particularly	particularly	ADV
admet-292	1637	12	helpful	helpful	ADJ
admet-292	1637	13	(	(	PUNCT
admet-292	1637	14	and	and	CCONJ
admet-292	1637	15	sometimes	sometimes	ADV
admet-292	1637	16	necessary	necessary	ADJ
admet-292	1637	17	)	)	PUNCT
admet-292	1637	18	to	to	PART
admet-292	1637	19	specify	specify	VERB
admet-292	1637	20	the	the	DET
admet-292	1637	21	actual	actual	ADJ
admet-292	1637	22	weight	weight	NOUN
admet-292	1637	23	of	of	ADP
admet-292	1637	24	sample	sample	NOUN
admet-292	1637	25	in	in	ADP
admet-292	1637	26	each	each	DET
admet-292	1637	27	vial	vial	NOUN
admet-292	1637	28	.	.	PUNCT
admet-292	1638	1	(	(	PUNCT
admet-292	1638	2	it	it	PRON
admet-292	1638	3	can	can	AUX
admet-292	1638	4	be	be	AUX
admet-292	1638	5	unhelpful	unhelpful	ADJ
admet-292	1638	6	to	to	PART
admet-292	1638	7	see	see	VERB
admet-292	1638	8	statements	statement	NOUN
admet-292	1638	9	such	such	ADJ
admet-292	1638	10	as	as	ADP
admet-292	1638	11	“	"	PUNCT
admet-292	1638	12	excess	excess	ADJ
admet-292	1638	13	solid	solid	NOUN
admet-292	1638	14	was	be	AUX
admet-292	1638	15	added	add	VERB
admet-292	1638	16	.	.	PUNCT
admet-292	1638	17	”	"	PUNCT
admet-292	1638	18	)	)	PUNCT
admet-292	1638	19	“	"	PUNCT
admet-292	1638	20	actual	actual	ADJ
admet-292	1638	21	weight	weight	NOUN
admet-292	1638	22	should	should	AUX
admet-292	1638	23	always	always	ADV
admet-292	1638	24	be	be	AUX
admet-292	1638	25	specified	specify	VERB
admet-292	1638	26	.	.	PUNCT
admet-292	1638	27	”	"	PUNCT
admet-292	1639	1	[	[	X
admet-292	1639	2	9yes	9yes	NUM
admet-292	1639	3	,	,	PUNCT
admet-292	1639	4	1no	1no	ADJ
admet-292	1639	5	]	]	X
admet-292	1639	6	it	it	PRON
admet-292	1639	7	is	be	AUX
admet-292	1639	8	not	not	PART
admet-292	1639	9	enough	enough	ADJ
admet-292	1639	10	to	to	PART
admet-292	1639	11	state	state	VERB
admet-292	1639	12	that	that	SCONJ
admet-292	1639	13	“	"	PUNCT
admet-292	1639	14	water	water	NOUN
admet-292	1639	15	was	be	AUX
admet-292	1639	16	used	use	VERB
admet-292	1639	17	”	"	PUNCT
admet-292	1639	18	as	as	ADP
admet-292	1639	19	the	the	DET
admet-292	1639	20	solvent	solvent	NOUN
admet-292	1639	21	.	.	PUNCT
admet-292	1640	1	was	be	AUX
admet-292	1640	2	there	there	PRON
admet-292	1640	3	any	any	DET
admet-292	1640	4	added	add	VERB
admet-292	1640	5	ionic	ionic	ADJ
admet-292	1640	6	strength	strength	NOUN
admet-292	1640	7	adjustor	adjustor	NOUN
admet-292	1640	8	(	(	PUNCT
admet-292	1640	9	e.g.	e.g.	ADV
admet-292	1640	10	,	,	PUNCT
admet-292	1640	11	0.15	0.15	NUM
admet-292	1640	12	m	m	NOUN
admet-292	1640	13	nacl	nacl	NOUN
admet-292	1640	14	,	,	PUNCT
admet-292	1640	15	etc	etc	X
admet-292	1640	16	.	.	X
admet-292	1640	17	)	)	PUNCT
admet-292	1640	18	?	?	PUNCT
admet-292	1641	1	was	be	AUX
admet-292	1641	2	carbon	carbon	NOUN
admet-292	1641	3	dioxide	dioxide	NOUN
admet-292	1641	4	purged	purge	VERB
admet-292	1641	5	out	out	ADP
admet-292	1641	6	?	?	PUNCT
admet-292	1642	1	low	low	ADJ
admet-292	1642	2	soluble	soluble	ADJ
admet-292	1642	3	bases	basis	NOUN
admet-292	1642	4	such	such	ADJ
admet-292	1642	5	as	as	ADP
admet-292	1642	6	terfenadine	terfenadine	NOUN
admet-292	1642	7	can	can	AUX
admet-292	1642	8	indicate	indicate	VERB
admet-292	1642	9	solubility	solubility	NOUN
admet-292	1642	10	over	over	ADP
admet-292	1642	11	several	several	ADJ
admet-292	1642	12	magnitudes	magnitude	NOUN
admet-292	1642	13	due	due	ADP
admet-292	1642	14	to	to	ADP
admet-292	1642	15	the	the	DET
admet-292	1642	16	effect	effect	NOUN
admet-292	1642	17	of	of	ADP
admet-292	1642	18	ambient	ambient	ADJ
admet-292	1642	19	co2	co2	NOUN
admet-292	1642	20	in	in	ADP
admet-292	1642	21	unbuffered	unbuffered	ADJ
admet-292	1642	22	solutions	solution	NOUN
admet-292	1642	23	.	.	PUNCT
admet-292	1643	1	“	"	PUNCT
admet-292	1643	2	all	all	DET
admet-292	1643	3	details	detail	NOUN
admet-292	1643	4	of	of	ADP
admet-292	1643	5	the	the	DET
admet-292	1643	6	method	method	NOUN
admet-292	1643	7	,	,	PUNCT
admet-292	1643	8	procedure	procedure	NOUN
admet-292	1643	9	,	,	PUNCT
admet-292	1643	10	have	have	VERB
admet-292	1643	11	to	to	PART
admet-292	1643	12	be	be	AUX
admet-292	1643	13	described	describe	VERB
admet-292	1643	14	.	.	PUNCT
admet-292	1643	15	”	"	PUNCT
admet-292	1644	1	ph	ph	ADJ
admet-292	1644	2	measurement	measurement	NOUN
admet-292	1644	3	using	use	VERB
admet-292	1644	4	glass	glass	NOUN
admet-292	1644	5	electrodes	electrode	NOUN
admet-292	1644	6	[	[	X
admet-292	1644	7	10yes	10yes	X
admet-292	1644	8	]	]	X
admet-292	1644	9	it	it	PRON
admet-292	1644	10	is	be	AUX
admet-292	1644	11	highly	highly	ADV
admet-292	1644	12	recommended	recommend	VERB
admet-292	1644	13	that	that	SCONJ
admet-292	1644	14	the	the	DET
admet-292	1644	15	final	final	ADJ
admet-292	1644	16	ph	ph	NOUN
admet-292	1644	17	of	of	ADP
admet-292	1644	18	the	the	DET
admet-292	1644	19	saturated	saturate	VERB
admet-292	1644	20	solution	solution	NOUN
admet-292	1644	21	be	be	AUX
admet-292	1644	22	carefully	carefully	ADV
admet-292	1644	23	measured	measure	VERB
admet-292	1644	24	,	,	PUNCT
admet-292	1644	25	using	use	VERB
admet-292	1644	26	a	a	DET
admet-292	1644	27	properly	properly	ADV
admet-292	1644	28	standardized	standardize	VERB
admet-292	1644	29	electrodes	electrode	NOUN
admet-292	1644	30	.	.	PUNCT
admet-292	1645	1	(	(	PUNCT
admet-292	1645	2	it	it	PRON
admet-292	1645	3	is	be	AUX
admet-292	1645	4	a	a	DET
admet-292	1645	5	risky	risky	ADJ
admet-292	1645	6	practice	practice	NOUN
admet-292	1645	7	to	to	PART
admet-292	1645	8	assume	assume	VERB
admet-292	1645	9	that	that	SCONJ
admet-292	1645	10	the	the	DET
admet-292	1645	11	assay	assay	NOUN
admet-292	1645	12	buffer	buffer	NOUN
admet-292	1645	13	ph	ph	NOUN
admet-292	1645	14	is	be	AUX
admet-292	1645	15	not	not	PART
admet-292	1645	16	altered	alter	VERB
admet-292	1645	17	by	by	ADP
admet-292	1645	18	the	the	DET
admet-292	1645	19	addition	addition	NOUN
admet-292	1645	20	of	of	ADP
admet-292	1645	21	sample	sample	NOUN
admet-292	1645	22	.	.	PUNCT
admet-292	1645	23	)	)	PUNCT
admet-292	1646	1	“	"	PUNCT
admet-292	1646	2	besides	besides	SCONJ
admet-292	1646	3	final	final	ADJ
admet-292	1646	4	ph	ph	NOUN
admet-292	1646	5	,	,	PUNCT
admet-292	1646	6	value	value	NOUN
admet-292	1646	7	of	of	ADP
admet-292	1646	8	the	the	DET
admet-292	1646	9	beginning	beginning	NOUN
admet-292	1646	10	and	and	CCONJ
admet-292	1646	11	,	,	PUNCT
admet-292	1646	12	for	for	ADP
admet-292	1646	13	example	example	NOUN
admet-292	1646	14	,	,	PUNCT
admet-292	1646	15	after	after	ADP
admet-292	1646	16	stirring	stir	VERB
admet-292	1646	17	,	,	PUNCT
admet-292	1646	18	should	should	AUX
admet-292	1646	19	be	be	AUX
admet-292	1646	20	indicated	indicate	VERB
admet-292	1646	21	.	.	PUNCT
admet-292	1646	22	”	"	PUNCT
admet-292	1647	1	[	[	X
admet-292	1647	2	10yes	10yes	X
admet-292	1647	3	]	]	X
admet-292	1647	4	particular	particular	ADJ
admet-292	1647	5	attention	attention	NOUN
admet-292	1647	6	should	should	AUX
admet-292	1647	7	be	be	AUX
admet-292	1647	8	given	give	VERB
admet-292	1647	9	to	to	ADP
admet-292	1647	10	the	the	DET
admet-292	1647	11	ph	ph	ADJ
admet-292	1647	12	electrode	electrode	NOUN
admet-292	1647	13	calibration	calibration	NOUN
admet-292	1647	14	,	,	PUNCT
admet-292	1647	15	especially	especially	ADV
admet-292	1647	16	when	when	SCONJ
admet-292	1647	17	extreme	extreme	ADJ
admet-292	1647	18	ph	ph	NOUN
admet-292	1647	19	is	be	AUX
admet-292	1647	20	measured	measure	VERB
admet-292	1647	21	(	(	PUNCT
admet-292	1647	22	ph<1	ph<1	PROPN
admet-292	1647	23	or	or	CCONJ
admet-292	1647	24	ph>12	ph>12	ADV
admet-292	1647	25	)	)	PUNCT
admet-292	1647	26	or	or	CCONJ
admet-292	1647	27	when	when	SCONJ
admet-292	1647	28	the	the	DET
admet-292	1647	29	ionic	ionic	ADJ
admet-292	1647	30	strength	strength	NOUN
admet-292	1647	31	reaches	reach	VERB
admet-292	1647	32	high	high	ADJ
admet-292	1647	33	values	value	NOUN
admet-292	1647	34	,	,	PUNCT
admet-292	1647	35	as	as	ADP
admet-292	1647	36	in	in	ADP
admet-292	1647	37	the	the	DET
admet-292	1647	38	case	case	NOUN
admet-292	1647	39	of	of	ADP
admet-292	1647	40	salt	salt	NOUN
admet-292	1647	41	solubility	solubility	NOUN
admet-292	1647	42	measurement	measurement	NOUN
admet-292	1647	43	.	.	PUNCT
admet-292	1648	1	[	[	X
admet-292	1648	2	7yes,3	7yes,3	NUM
admet-292	1648	3	?	?	PUNCT
admet-292	1648	4	]	]	PUNCT
admet-292	1648	5	state	state	NOUN
admet-292	1648	6	whether	whether	SCONJ
admet-292	1648	7	the	the	DET
admet-292	1648	8	reported	report	VERB
admet-292	1648	9	ph	ph	NOUN
admet-292	1648	10	is	be	AUX
admet-292	1648	11	on	on	ADP
admet-292	1648	12	the	the	DET
admet-292	1648	13	“	"	PUNCT
admet-292	1648	14	operational	operational	ADJ
admet-292	1648	15	”	"	PUNCT
admet-292	1648	16	or	or	CCONJ
admet-292	1648	17	the	the	DET
admet-292	1648	18	“	"	PUNCT
admet-292	1648	19	concentration	concentration	NOUN
admet-292	1648	20	”	"	PUNCT
admet-292	1648	21	scale	scale	NOUN
admet-292	1648	22	.	.	PUNCT
admet-292	1649	1	the	the	DET
admet-292	1649	2	“	"	PUNCT
admet-292	1649	3	mixed	mixed	ADJ
admet-292	1649	4	”	"	PUNCT
admet-292	1649	5	scale	scale	NOUN
admet-292	1649	6	is	be	AUX
admet-292	1649	7	not	not	PART
admet-292	1649	8	recommended	recommend	VERB
admet-292	1649	9	.	.	PUNCT
admet-292	1650	1	admet	admet	PROPN
admet-292	1650	2	&	&	CCONJ
admet-292	1650	3	dmpk	dmpk	PROPN
admet-292	1650	4	4(2	4(2	NUM
admet-292	1650	5	)	)	PUNCT
admet-292	1650	6	(	(	PUNCT
admet-292	1650	7	2016	2016	NUM
admet-292	1650	8	)	)	PUNCT
admet-292	1650	9	117	117	NUM
admet-292	1650	10	-	-	SYM
admet-292	1650	11	178	178	NUM
admet-292	1650	12	consensus	consensus	NOUN
admet-292	1650	13	recommendations	recommendation	NOUN
admet-292	1650	14	for	for	ADP
admet-292	1650	15	improving	improve	VERB
admet-292	1650	16	solubility	solubility	NOUN
admet-292	1650	17	-	-	PUNCT
admet-292	1650	18	ph	ph	ADJ
admet-292	1650	19	data	datum	NOUN
admet-292	1650	20	quality	quality	NOUN
admet-292	1650	21	doi	doi	NOUN
admet-292	1650	22	:	:	PUNCT
admet-292	1650	23	10.5599	10.5599	NUM
admet-292	1650	24	/	/	SYM
admet-292	1650	25	admet.4.2.292	admet.4.2.292	PROPN
admet-292	1650	26	173	173	NUM
admet-292	1650	27	“	"	PUNCT
admet-292	1650	28	the	the	DET
admet-292	1650	29	definition	definition	NOUN
admet-292	1650	30	of	of	ADP
admet-292	1650	31	operational	operational	ADJ
admet-292	1650	32	ph	ph	ADJ
admet-292	1650	33	and	and	CCONJ
admet-292	1650	34	mixed	mixed	ADJ
admet-292	1650	35	ph	ph	ADJ
admet-292	1650	36	scales	scale	NOUN
admet-292	1650	37	should	should	AUX
admet-292	1650	38	be	be	AUX
admet-292	1650	39	provided	provide	VERB
admet-292	1650	40	.	.	PUNCT
admet-292	1651	1	if	if	SCONJ
admet-292	1651	2	mixed	mixed	ADJ
admet-292	1651	3	scale	scale	NOUN
admet-292	1651	4	refers	refer	VERB
admet-292	1651	5	to	to	ADP
admet-292	1651	6	the	the	DET
admet-292	1651	7	measurement	measurement	NOUN
admet-292	1651	8	of	of	ADP
admet-292	1651	9	h	h	NOUN
admet-292	1651	10	+	+	CCONJ
admet-292	1651	11	in	in	ADP
admet-292	1651	12	activities	activity	NOUN
admet-292	1651	13	and	and	CCONJ
admet-292	1651	14	the	the	DET
admet-292	1651	15	rest	rest	NOUN
admet-292	1651	16	of	of	ADP
admet-292	1651	17	species	specie	NOUN
admet-292	1651	18	in	in	ADP
admet-292	1651	19	concentrations	concentration	NOUN
admet-292	1651	20	,	,	PUNCT
admet-292	1651	21	we	we	PRON
admet-292	1651	22	do	do	AUX
admet-292	1651	23	n’t	not	PART
admet-292	1651	24	see	see	VERB
admet-292	1651	25	why	why	SCONJ
admet-292	1651	26	the	the	DET
admet-292	1651	27	mixed	mixed	ADJ
admet-292	1651	28	scale	scale	NOUN
admet-292	1651	29	is	be	AUX
admet-292	1651	30	not	not	PART
admet-292	1651	31	recommended	recommend	VERB
admet-292	1651	32	if	if	SCONJ
admet-292	1651	33	everything	everything	PRON
admet-292	1651	34	is	be	AUX
admet-292	1651	35	well	well	ADV
admet-292	1651	36	specified	specify	VERB
admet-292	1651	37	.	.	PUNCT
admet-292	1651	38	”	"	PUNCT
admet-292	1652	1	“	"	PUNCT
admet-292	1652	2	operational	operational	ADJ
admet-292	1652	3	[	[	X
admet-292	1652	4	is	be	AUX
admet-292	1652	5	preferred	prefer	VERB
admet-292	1652	6	]	]	PUNCT
admet-292	1652	7	.	.	PUNCT
admet-292	1652	8	”	"	PUNCT
admet-292	1653	1	[	[	X
admet-292	1653	2	6yes	6ye	NOUN
admet-292	1653	3	,	,	PUNCT
admet-292	1653	4	4	4	NUM
admet-292	1653	5	?	?	NUM
admet-292	1653	6	]	]	X
admet-292	1653	7	a	a	DET
admet-292	1653	8	strong	strong	ADJ
admet-292	1653	9	case	case	NOUN
admet-292	1653	10	can	can	AUX
admet-292	1653	11	be	be	AUX
admet-292	1653	12	made	make	VERB
admet-292	1653	13	that	that	DET
admet-292	1653	14	general	general	ADJ
admet-292	1653	15	solubility	solubility	NOUN
admet-292	1653	16	equilibrium	equilibrium	NOUN
admet-292	1653	17	quotients	quotient	NOUN
admet-292	1653	18	are	be	AUX
admet-292	1653	19	best	well	ADV
admet-292	1653	20	formulated	formulate	VERB
admet-292	1653	21	in	in	ADP
admet-292	1653	22	the	the	DET
admet-292	1653	23	concentration	concentration	NOUN
admet-292	1653	24	scale	scale	NOUN
admet-292	1653	25	(	(	PUNCT
admet-292	1653	26	rather	rather	ADV
admet-292	1653	27	than	than	ADP
admet-292	1653	28	activity	activity	NOUN
admet-292	1653	29	)	)	PUNCT
admet-292	1653	30	,	,	PUNCT
admet-292	1653	31	with	with	SCONJ
admet-292	1653	32	ph	ph	ADJ
admet-292	1653	33	electrodes	electrode	NOUN
admet-292	1653	34	standardized	standardize	VERB
admet-292	1653	35	in	in	ADP
admet-292	1653	36	a	a	DET
admet-292	1653	37	constant	constant	ADJ
admet-292	1653	38	ionic	ionic	ADJ
admet-292	1653	39	medium	medium	NOUN
admet-292	1653	40	,	,	PUNCT
admet-292	1653	41	e.g.	e.g.	ADV
admet-292	1653	42	,	,	PUNCT
admet-292	1653	43	0.15	0.15	NUM
admet-292	1653	44	m	m	NOUN
admet-292	1653	45	nacl	nacl	ADJ
admet-292	1653	46	.	.	PUNCT
admet-292	1654	1	this	this	PRON
admet-292	1654	2	may	may	AUX
admet-292	1654	3	be	be	AUX
admet-292	1654	4	especially	especially	ADV
admet-292	1654	5	important	important	ADJ
admet-292	1654	6	when	when	SCONJ
admet-292	1654	7	salt	salt	NOUN
admet-292	1654	8	solubility	solubility	NOUN
admet-292	1654	9	measurements	measurement	NOUN
admet-292	1654	10	are	be	AUX
admet-292	1654	11	performed	perform	VERB
admet-292	1654	12	.	.	PUNCT
admet-292	1655	1	“	"	PUNCT
admet-292	1655	2	we	we	PRON
admet-292	1655	3	have	have	AUX
admet-292	1655	4	never	never	ADV
admet-292	1655	5	done	do	VERB
admet-292	1655	6	that	that	PRON
admet-292	1655	7	,	,	PUNCT
admet-292	1655	8	but	but	CCONJ
admet-292	1655	9	can	can	AUX
admet-292	1655	10	be	be	AUX
admet-292	1655	11	a	a	DET
admet-292	1655	12	good	good	ADJ
admet-292	1655	13	idea	idea	NOUN
admet-292	1655	14	.	.	PUNCT
admet-292	1655	15	“	"	PUNCT
admet-292	1656	1	[	[	X
admet-292	1656	2	8yes	8ye	NOUN
admet-292	1656	3	,	,	PUNCT
admet-292	1656	4	1	1	NUM
admet-292	1656	5	?	?	NUM
admet-292	1656	6	,	,	PUNCT
admet-292	1656	7	1no	1no	ADJ
admet-292	1656	8	]	]	X
admet-292	1656	9	state	state	NOUN
admet-292	1656	10	how	how	SCONJ
admet-292	1656	11	ph	ph	ADJ
admet-292	1656	12	was	be	AUX
admet-292	1656	13	adjusted	adjust	VERB
admet-292	1656	14	(	(	PUNCT
admet-292	1656	15	e.g.	e.g.	ADV
admet-292	1656	16	,	,	PUNCT
admet-292	1656	17	0.1	0.1	NUM
admet-292	1656	18	m	m	NOUN
admet-292	1656	19	hcl	hcl	PROPN
admet-292	1656	20	,	,	PUNCT
admet-292	1656	21	1	1	NUM
admet-292	1656	22	m	m	NOUN
admet-292	1656	23	naoh	naoh	NOUN
admet-292	1656	24	,	,	PUNCT
admet-292	1656	25	etc	etc	X
admet-292	1656	26	.	.	X
admet-292	1656	27	)	)	PUNCT
admet-292	1656	28	.	.	PUNCT
admet-292	1657	1	statements	statement	NOUN
admet-292	1657	2	like	like	ADP
admet-292	1657	3	:	:	PUNCT
admet-292	1657	4	“	"	PUNCT
admet-292	1657	5	concentrated	concentrated	ADJ
admet-292	1657	6	h3po4	h3po4	NOUN
admet-292	1657	7	was	be	AUX
admet-292	1657	8	added	add	VERB
admet-292	1657	9	drop	drop	NOUN
admet-292	1657	10	-	-	ADJ
admet-292	1657	11	wise	wise	ADJ
admet-292	1657	12	to	to	PART
admet-292	1657	13	adjust	adjust	VERB
admet-292	1657	14	the	the	DET
admet-292	1657	15	ph	ph	NOUN
admet-292	1657	16	”	"	PUNCT
admet-292	1657	17	are	be	AUX
admet-292	1657	18	not	not	PART
admet-292	1657	19	clear	clear	ADJ
admet-292	1657	20	enough	enough	ADV
admet-292	1657	21	.	.	PUNCT
admet-292	1658	1	it	it	PRON
admet-292	1658	2	is	be	AUX
admet-292	1658	3	far	far	ADV
admet-292	1658	4	better	well	ADJ
admet-292	1658	5	to	to	PART
admet-292	1658	6	state	state	VERB
admet-292	1658	7	the	the	DET
admet-292	1658	8	precise	precise	ADJ
admet-292	1658	9	concentration	concentration	NOUN
admet-292	1658	10	and	and	CCONJ
admet-292	1658	11	volume	volume	NOUN
admet-292	1658	12	of	of	ADP
admet-292	1658	13	the	the	DET
admet-292	1658	14	titrant	titrant	NOUN
admet-292	1658	15	used	use	VERB
admet-292	1658	16	to	to	PART
admet-292	1658	17	adjust	adjust	VERB
admet-292	1658	18	the	the	DET
admet-292	1658	19	ph	ph	NOUN
admet-292	1658	20	to	to	ADP
admet-292	1658	21	the	the	DET
admet-292	1658	22	desired	desire	VERB
admet-292	1658	23	starting	starting	NOUN
admet-292	1658	24	point	point	NOUN
admet-292	1658	25	.	.	PUNCT
admet-292	1659	1	“	"	PUNCT
admet-292	1659	2	we	we	PRON
admet-292	1659	3	agree	agree	VERB
admet-292	1659	4	with	with	ADP
admet-292	1659	5	the	the	DET
admet-292	1659	6	comment	comment	NOUN
admet-292	1659	7	.	.	PUNCT
admet-292	1660	1	“	"	PUNCT
admet-292	1660	2	buffers	buffer	NOUN
admet-292	1660	3	[	[	X
admet-292	1660	4	10yes	10yes	X
admet-292	1660	5	]	]	X
admet-292	1660	6	it	it	PRON
admet-292	1660	7	is	be	AUX
admet-292	1660	8	inadequate	inadequate	ADJ
admet-292	1660	9	to	to	AUX
admet-292	1660	10	state	state	VERB
admet-292	1660	11	that	that	SCONJ
admet-292	1660	12	“	"	PUNCT
admet-292	1660	13	buffers	buffer	NOUN
admet-292	1660	14	were	be	AUX
admet-292	1660	15	used	use	VERB
admet-292	1660	16	”	"	PUNCT
admet-292	1660	17	.	.	PUNCT
admet-292	1661	1	state	state	NOUN
admet-292	1661	2	precisely	precisely	ADV
admet-292	1661	3	which	which	DET
admet-292	1661	4	buffer	buffer	NOUN
admet-292	1661	5	compounds	compound	NOUN
admet-292	1661	6	were	be	AUX
admet-292	1661	7	used	use	VERB
admet-292	1661	8	.	.	PUNCT
admet-292	1662	1	problems	problem	NOUN
admet-292	1662	2	with	with	ADP
admet-292	1662	3	specific	specific	ADJ
admet-292	1662	4	buffers	buffer	NOUN
admet-292	1662	5	can	can	AUX
admet-292	1662	6	occur	occur	VERB
admet-292	1662	7	so	so	SCONJ
admet-292	1662	8	it	it	PRON
admet-292	1662	9	is	be	AUX
admet-292	1662	10	important	important	ADJ
admet-292	1662	11	to	to	PART
admet-292	1662	12	specify	specify	VERB
admet-292	1662	13	the	the	DET
admet-292	1662	14	nature	nature	NOUN
admet-292	1662	15	.	.	PUNCT
admet-292	1663	1	[	[	X
admet-292	1663	2	10yes	10yes	X
admet-292	1663	3	]	]	X
admet-292	1663	4	state	state	NOUN
admet-292	1663	5	which	which	PRON
admet-292	1663	6	salt	salt	NOUN
admet-292	1663	7	forms	form	NOUN
admet-292	1663	8	of	of	ADP
admet-292	1663	9	buffers	buffer	NOUN
admet-292	1663	10	were	be	AUX
admet-292	1663	11	used	use	VERB
admet-292	1663	12	(	(	PUNCT
admet-292	1663	13	e.g.	e.g.	ADJ
admet-292	1663	14	,	,	PUNCT
admet-292	1663	15	kh2po4	kh2po4	NOUN
admet-292	1663	16	,	,	PUNCT
admet-292	1663	17	na2hpo4.2	na2hpo4.2	NUM
admet-292	1663	18	h2o	h2o	NOUN
admet-292	1663	19	)	)	PUNCT
admet-292	1663	20	.	.	PUNCT
admet-292	1664	1	[	[	X
admet-292	1664	2	9yes	9yes	NUM
admet-292	1664	3	,	,	PUNCT
admet-292	1664	4	1no	1no	ADJ
admet-292	1664	5	]	]	PUNCT
admet-292	1664	6	state	state	NOUN
admet-292	1664	7	the	the	DET
admet-292	1664	8	concentrations	concentration	NOUN
admet-292	1664	9	of	of	ADP
admet-292	1664	10	the	the	DET
admet-292	1664	11	buffers	buffer	NOUN
admet-292	1664	12	,	,	PUNCT
admet-292	1664	13	since	since	SCONJ
admet-292	1664	14	this	this	PRON
admet-292	1664	15	will	will	AUX
admet-292	1664	16	be	be	AUX
admet-292	1664	17	needed	need	VERB
admet-292	1664	18	to	to	PART
admet-292	1664	19	calculate	calculate	VERB
admet-292	1664	20	the	the	DET
admet-292	1664	21	total	total	ADJ
admet-292	1664	22	ionic	ionic	ADJ
admet-292	1664	23	strength	strength	NOUN
admet-292	1664	24	.	.	PUNCT
admet-292	1665	1	ordinarily	ordinarily	ADV
admet-292	1665	2	,	,	PUNCT
admet-292	1665	3	relatively	relatively	ADV
admet-292	1665	4	low	low	ADJ
admet-292	1665	5	buffer	buffer	NOUN
admet-292	1665	6	concentrations	concentration	NOUN
admet-292	1665	7	(	(	PUNCT
admet-292	1665	8	e.g.	e.g.	ADV
admet-292	1665	9	,	,	PUNCT
admet-292	1665	10	5	5	NUM
admet-292	1665	11	-	-	SYM
admet-292	1665	12	10	10	NUM
admet-292	1665	13	mm	mm	NOUN
admet-292	1665	14	)	)	PUNCT
admet-292	1665	15	can	can	AUX
admet-292	1665	16	be	be	AUX
admet-292	1665	17	recommended	recommend	VERB
admet-292	1665	18	.	.	PUNCT
admet-292	1666	1	“	"	PUNCT
admet-292	1666	2	10	10	NUM
admet-292	1666	3	mm	mm	NOUN
admet-292	1666	4	is	be	AUX
admet-292	1666	5	not	not	PART
admet-292	1666	6	enough	enough	ADJ
admet-292	1666	7	to	to	PART
admet-292	1666	8	buffer	buffer	VERB
admet-292	1666	9	solutions	solution	NOUN
admet-292	1666	10	of	of	ADP
admet-292	1666	11	compounds	compound	NOUN
admet-292	1666	12	with	with	ADP
admet-292	1666	13	relatively	relatively	ADV
admet-292	1666	14	high	high	ADJ
admet-292	1666	15	solubility	solubility	NOUN
admet-292	1666	16	”	"	PUNCT
admet-292	1667	1	[	[	X
admet-292	1667	2	6yes	6ye	NOUN
admet-292	1667	3	,	,	PUNCT
admet-292	1667	4	3	3	NUM
admet-292	1667	5	?	?	NUM
admet-292	1667	6	,	,	PUNCT
admet-292	1667	7	1no	1no	NOUN
admet-292	1667	8	]	]	PUNCT
admet-292	1667	9	some	some	DET
admet-292	1667	10	buffers	buffer	NOUN
admet-292	1667	11	have	have	VERB
admet-292	1667	12	inappropriately	inappropriately	ADV
admet-292	1667	13	high	high	ADJ
admet-292	1667	14	uv	uv	NOUN
admet-292	1667	15	absorptivity	absorptivity	NOUN
admet-292	1667	16	,	,	PUNCT
admet-292	1667	17	if	if	SCONJ
admet-292	1667	18	concentration	concentration	NOUN
admet-292	1667	19	is	be	AUX
admet-292	1667	20	determined	determine	VERB
admet-292	1667	21	by	by	ADP
admet-292	1667	22	uv	uv	NOUN
admet-292	1667	23	spectroscopy	spectroscopy	NOUN
admet-292	1667	24	.	.	PUNCT
admet-292	1668	1	list	list	VERB
admet-292	1668	2	some	some	DET
admet-292	1668	3	examples	example	NOUN
admet-292	1668	4	of	of	ADP
admet-292	1668	5	buffers	buffer	NOUN
admet-292	1668	6	to	to	PART
admet-292	1668	7	avoid	avoid	VERB
admet-292	1668	8	.	.	PUNCT
admet-292	1669	1	“	"	PUNCT
admet-292	1669	2	we	we	PRON
admet-292	1669	3	normally	normally	ADV
admet-292	1669	4	use	use	VERB
admet-292	1669	5	hplc	hplc	NOUN
admet-292	1669	6	for	for	ADP
admet-292	1669	7	compound	compound	NOUN
admet-292	1669	8	quantification	quantification	NOUN
admet-292	1669	9	.	.	PUNCT
admet-292	1669	10	”	"	PUNCT
admet-292	1670	1	“	"	PUNCT
admet-292	1670	2	hepes	hepe	NOUN
admet-292	1670	3	,	,	PUNCT
admet-292	1670	4	phosphate	phosphate	NOUN
admet-292	1670	5	buffer(s	buffer(s	NOUN
admet-292	1670	6	)	)	PUNCT
admet-292	1671	1	[	[	X
admet-292	1671	2	are	be	AUX
admet-292	1671	3	to	to	PART
admet-292	1671	4	be	be	AUX
admet-292	1671	5	avoided	avoid	VERB
admet-292	1671	6	]	]	PUNCT
admet-292	1671	7	if	if	SCONJ
admet-292	1671	8	[	[	X
admet-292	1671	9	sample	sample	NOUN
admet-292	1671	10	]	]	PUNCT
admet-292	1671	11	substance	substance	NOUN
admet-292	1671	12	absorbs	absorb	VERB
admet-292	1671	13	below	below	ADP
admet-292	1671	14	240	240	NUM
admet-292	1671	15	-	-	SYM
admet-292	1671	16	250	250	NUM
admet-292	1671	17	nm	nm	NOUN
admet-292	1671	18	.	.	PUNCT
admet-292	1671	19	”	"	PUNCT
admet-292	1671	20	separating	separate	VERB
admet-292	1671	21	solid	solid	ADV
admet-292	1671	22	from	from	ADP
admet-292	1671	23	saturated	saturate	VERB
admet-292	1671	24	solution	solution	NOUN
admet-292	1671	25	[	[	X
admet-292	1671	26	7yes	7yes	NOUN
admet-292	1671	27	,	,	PUNCT
admet-292	1671	28	2	2	NUM
admet-292	1671	29	?	?	NUM
admet-292	1671	30	,	,	PUNCT
admet-292	1671	31	1no	1no	ADJ
admet-292	1671	32	]	]	PUNCT
admet-292	1671	33	filtration	filtration	NOUN
admet-292	1671	34	is	be	AUX
admet-292	1671	35	recommended	recommend	VERB
admet-292	1671	36	,	,	PUNCT
admet-292	1671	37	using	use	VERB
admet-292	1671	38	hydrophilic	hydrophilic	ADJ
admet-292	1671	39	filters	filter	NOUN
admet-292	1671	40	,	,	PUNCT
admet-292	1671	41	typically	typically	ADV
admet-292	1671	42	0.2	0.2	NUM
admet-292	1671	43	-	-	PUNCT
admet-292	1671	44	0.45	0.45	NUM
admet-292	1671	45	μm	μm	NUM
admet-292	1671	46	pore	pore	ADJ
admet-292	1671	47	sizes	size	NOUN
admet-292	1671	48	.	.	PUNCT
admet-292	1672	1	“	"	PUNCT
admet-292	1672	2	as	as	SCONJ
admet-292	1672	3	krisztina	krisztina	PROPN
admet-292	1672	4	said	say	VERB
admet-292	1672	5	,	,	PUNCT
admet-292	1672	6	it	it	PRON
admet-292	1672	7	depends	depend	VERB
admet-292	1672	8	on	on	ADP
admet-292	1672	9	the	the	DET
admet-292	1672	10	pka	pka	NOUN
admet-292	1672	11	of	of	ADP
admet-292	1672	12	the	the	DET
admet-292	1672	13	compound	compound	NOUN
admet-292	1672	14	and	and	CCONJ
admet-292	1672	15	also	also	ADV
admet-292	1672	16	its	its	PRON
admet-292	1672	17	log	log	NOUN
admet-292	1672	18	p.	p.	NOUN
admet-292	1672	19	”	"	PUNCT
admet-292	1672	20	“	"	PUNCT
admet-292	1672	21	type	type	NOUN
admet-292	1672	22	of	of	ADP
admet-292	1672	23	filters	filter	NOUN
admet-292	1672	24	may	may	AUX
admet-292	1672	25	influence	influence	VERB
admet-292	1672	26	the	the	DET
admet-292	1672	27	so	so	ADJ
admet-292	1672	28	value	value	NOUN
admet-292	1672	29	;	;	PUNCT
admet-292	1672	30	maybe	maybe	ADV
admet-292	1672	31	several	several	ADJ
admet-292	1672	32	types	type	NOUN
admet-292	1672	33	of	of	ADP
admet-292	1672	34	filters	filter	NOUN
admet-292	1672	35	should	should	AUX
admet-292	1672	36	be	be	AUX
admet-292	1672	37	used	use	VERB
admet-292	1672	38	(	(	PUNCT
admet-292	1672	39	depending	depend	VERB
admet-292	1672	40	on	on	ADP
admet-292	1672	41	the	the	DET
admet-292	1672	42	pka	pka	PROPN
admet-292	1672	43	value	value	NOUN
admet-292	1672	44	and	and	CCONJ
admet-292	1672	45	ph	ph	NOUN
admet-292	1672	46	of	of	ADP
admet-292	1672	47	solution	solution	NOUN
admet-292	1672	48	)	)	PUNCT
admet-292	1672	49	.	.	PUNCT
admet-292	1672	50	”	"	PUNCT
admet-292	1673	1	“	"	PUNCT
admet-292	1673	2	filtration	filtration	NOUN
admet-292	1673	3	is	be	AUX
admet-292	1673	4	very	very	ADV
admet-292	1673	5	time	time	NOUN
admet-292	1673	6	consuming	consume	VERB
admet-292	1673	7	and	and	CCONJ
admet-292	1673	8	for	for	ADP
admet-292	1673	9	industry	industry	NOUN
admet-292	1673	10	it	it	PRON
admet-292	1673	11	is	be	AUX
admet-292	1673	12	preferred	prefer	VERB
admet-292	1673	13	to	to	PART
admet-292	1673	14	do	do	VERB
admet-292	1673	15	centrifugation	centrifugation	NOUN
admet-292	1673	16	.	.	PUNCT
admet-292	1674	1	we	we	PRON
admet-292	1674	2	have	have	AUX
admet-292	1674	3	performed	perform	VERB
admet-292	1674	4	centrifugation	centrifugation	NOUN
admet-292	1674	5	for	for	ADP
admet-292	1674	6	a	a	DET
admet-292	1674	7	5	5	NUM
admet-292	1674	8	or	or	CCONJ
admet-292	1674	9	6	6	NUM
admet-292	1674	10	years	year	NOUN
admet-292	1674	11	and	and	CCONJ
admet-292	1674	12	no	no	DET
admet-292	1674	13	problem	problem	NOUN
admet-292	1674	14	was	be	AUX
admet-292	1674	15	encountered	encounter	VERB
admet-292	1674	16	yet	yet	ADV
admet-292	1674	17	.	.	PUNCT
admet-292	1675	1	perhaps	perhaps	ADV
admet-292	1675	2	some	some	DET
admet-292	1675	3	micellar	micellar	ADJ
admet-292	1675	4	problems	problem	NOUN
admet-292	1675	5	were	be	AUX
admet-292	1675	6	encountered	encounter	VERB
admet-292	1675	7	but	but	CCONJ
admet-292	1675	8	the	the	DET
admet-292	1675	9	detection	detection	NOUN
admet-292	1675	10	of	of	ADP
admet-292	1675	11	this	this	PRON
admet-292	1675	12	is	be	AUX
admet-292	1675	13	not	not	PART
admet-292	1675	14	always	always	ADV
admet-292	1675	15	clear	clear	ADJ
admet-292	1675	16	.	.	PUNCT
admet-292	1676	1	a	a	DET
admet-292	1676	2	better	well	ADJ
admet-292	1676	3	way	way	NOUN
admet-292	1676	4	to	to	PART
admet-292	1676	5	find	find	VERB
admet-292	1676	6	those	those	DET
admet-292	1676	7	problems	problem	NOUN
admet-292	1676	8	could	could	AUX
admet-292	1676	9	be	be	AUX
admet-292	1676	10	advisable	advisable	ADJ
admet-292	1676	11	.	.	PUNCT
admet-292	1676	12	”	"	PUNCT
admet-292	1677	1	[	[	X
admet-292	1677	2	8yes	8ye	NOUN
admet-292	1677	3	,	,	PUNCT
admet-292	1677	4	2	2	NUM
admet-292	1677	5	?	?	NUM
admet-292	1677	6	]	]	X
admet-292	1677	7	it	it	PRON
admet-292	1677	8	is	be	AUX
admet-292	1677	9	useful	useful	ADJ
admet-292	1677	10	to	to	PART
admet-292	1677	11	discard	discard	VERB
admet-292	1677	12	the	the	DET
admet-292	1677	13	first	first	ADJ
admet-292	1677	14	10	10	NUM
admet-292	1677	15	-	-	SYM
admet-292	1677	16	25	25	NUM
admet-292	1677	17	%	%	NOUN
admet-292	1677	18	filtered	filter	VERB
admet-292	1677	19	solution	solution	NOUN
admet-292	1677	20	,	,	PUNCT
admet-292	1677	21	to	to	PART
admet-292	1677	22	allow	allow	VERB
admet-292	1677	23	filters	filter	NOUN
admet-292	1677	24	and	and	CCONJ
admet-292	1677	25	vial	vial	ADJ
admet-292	1677	26	surfaces	surface	NOUN
admet-292	1677	27	to	to	PART
admet-292	1677	28	be	be	AUX
admet-292	1677	29	saturated	saturate	VERB
admet-292	1677	30	with	with	ADP
admet-292	1677	31	adsorbed	adsorb	VERB
admet-292	1677	32	compound	compound	NOUN
admet-292	1677	33	.	.	PUNCT
admet-292	1678	1	the	the	DET
admet-292	1678	2	filtration	filtration	NOUN
admet-292	1678	3	step	step	NOUN
admet-292	1678	4	should	should	AUX
admet-292	1678	5	not	not	PART
admet-292	1678	6	be	be	AUX
admet-292	1678	7	rushed	rush	VERB
admet-292	1678	8	.	.	PUNCT
admet-292	1679	1	alex	alex	PROPN
admet-292	1679	2	avdeef	avdeef	PROPN
admet-292	1679	3	et	et	PROPN
admet-292	1679	4	al	al	PROPN
admet-292	1679	5	.	.	PROPN
admet-292	1679	6	admet	admet	PROPN
admet-292	1679	7	&	&	CCONJ
admet-292	1679	8	dmpk	dmpk	PROPN
admet-292	1679	9	4(2	4(2	NUM
admet-292	1679	10	)	)	PUNCT
admet-292	1679	11	(	(	PUNCT
admet-292	1679	12	2016	2016	NUM
admet-292	1679	13	)	)	PUNCT
admet-292	1679	14	117	117	NUM
admet-292	1679	15	-	-	SYM
admet-292	1679	16	178	178	NUM
admet-292	1679	17	174	174	NUM
admet-292	1679	18	“	"	PUNCT
admet-292	1679	19	one	one	PRON
admet-292	1679	20	must	must	AUX
admet-292	1679	21	take	take	VERB
admet-292	1679	22	care	care	NOUN
admet-292	1679	23	that	that	SCONJ
admet-292	1679	24	no	no	DET
admet-292	1679	25	change	change	NOUN
admet-292	1679	26	in	in	ADP
admet-292	1679	27	the	the	DET
admet-292	1679	28	solid	solid	ADJ
admet-292	1679	29	form	form	NOUN
admet-292	1679	30	occurs	occur	VERB
admet-292	1679	31	during	during	ADP
admet-292	1679	32	filtering	filter	VERB
admet-292	1679	33	(	(	PUNCT
admet-292	1679	34	possible	possible	ADJ
admet-292	1679	35	for	for	ADP
admet-292	1679	36	highly	highly	ADV
admet-292	1679	37	polymorphic	polymorphic	ADJ
admet-292	1679	38	[	[	X
admet-292	1679	39	prone	prone	ADJ
admet-292	1679	40	]	]	PUNCT
admet-292	1679	41	solids	solid	NOUN
admet-292	1679	42	)	)	PUNCT
admet-292	1679	43	.	.	PUNCT
admet-292	1679	44	”	"	PUNCT
admet-292	1680	1	[	[	X
admet-292	1680	2	6yes	6ye	NOUN
admet-292	1680	3	,	,	PUNCT
admet-292	1680	4	3	3	NUM
admet-292	1680	5	?	?	NUM
admet-292	1680	6	,	,	PUNCT
admet-292	1680	7	1no	1no	NOUN
admet-292	1680	8	]	]	X
admet-292	1680	9	if	if	SCONJ
admet-292	1680	10	colloidal	colloidal	NOUN
admet-292	1680	11	dispersions	dispersion	NOUN
admet-292	1680	12	or	or	CCONJ
admet-292	1680	13	“	"	PUNCT
admet-292	1680	14	promiscuous	promiscuous	ADJ
admet-292	1680	15	inhibitors	inhibitor	NOUN
admet-292	1680	16	”	"	PUNCT
admet-292	1680	17	(	(	PUNCT
admet-292	1680	18	mcgovern	mcgovern	PROPN
admet-292	1680	19	et	et	PROPN
admet-292	1680	20	al	al	PROPN
admet-292	1680	21	.	.	PUNCT
admet-292	1680	22	j.	j.	PROPN
admet-292	1680	23	med	med	PROPN
admet-292	1680	24	.	.	PROPN
admet-292	1680	25	chem	chem	PROPN
admet-292	1680	26	.	.	PUNCT
admet-292	1681	1	2002	2002	NUM
admet-292	1681	2	,	,	PUNCT
admet-292	1681	3	45	45	NUM
admet-292	1681	4	,	,	PUNCT
admet-292	1681	5	1712	1712	NUM
admet-292	1681	6	-	-	SYM
admet-292	1681	7	1722	1722	NUM
admet-292	1681	8	)	)	PUNCT
admet-292	1681	9	are	be	AUX
admet-292	1681	10	suspected	suspect	VERB
admet-292	1681	11	,	,	PUNCT
admet-292	1681	12	then	then	ADV
admet-292	1681	13	the	the	DET
admet-292	1681	14	filtered	filter	VERB
admet-292	1681	15	solutions	solution	NOUN
admet-292	1681	16	may	may	AUX
admet-292	1681	17	be	be	AUX
admet-292	1681	18	further	far	ADV
admet-292	1681	19	subjected	subject	VERB
admet-292	1681	20	to	to	ADP
admet-292	1681	21	ultracentrifugation	ultracentrifugation	NOUN
admet-292	1681	22	.	.	PUNCT
admet-292	1682	1	[	[	X
admet-292	1682	2	7yes	7yes	NUM
admet-292	1682	3	,	,	PUNCT
admet-292	1682	4	2	2	NUM
admet-292	1682	5	?	?	NUM
admet-292	1682	6	,	,	PUNCT
admet-292	1682	7	1no	1no	NOUN
admet-292	1682	8	]	]	PUNCT
admet-292	1683	1	it	it	PRON
admet-292	1683	2	is	be	AUX
admet-292	1683	3	highly	highly	ADV
admet-292	1683	4	inadvisable	inadvisable	ADJ
admet-292	1683	5	to	to	PART
admet-292	1683	6	centrifuge	centrifuge	VERB
admet-292	1683	7	first	first	ADV
admet-292	1683	8	and	and	CCONJ
admet-292	1683	9	then	then	ADV
admet-292	1683	10	filter	filter	VERB
admet-292	1683	11	.	.	PUNCT
admet-292	1684	1	additional	additional	ADJ
admet-292	1684	2	comments	comment	NOUN
admet-292	1684	3	/	/	SYM
admet-292	1684	4	suggestions	suggestion	NOUN
admet-292	1684	5	“	"	PUNCT
admet-292	1684	6	a	a	DET
admet-292	1684	7	mass	mass	ADJ
admet-292	1684	8	spectrometer	spectrometer	NOUN
admet-292	1684	9	can	can	AUX
admet-292	1684	10	be	be	AUX
admet-292	1684	11	very	very	ADV
admet-292	1684	12	helpful	helpful	ADJ
admet-292	1684	13	in	in	ADP
admet-292	1684	14	cases	case	NOUN
admet-292	1684	15	of	of	ADP
admet-292	1684	16	low	low	ADJ
admet-292	1684	17	sensitivity	sensitivity	NOUN
admet-292	1684	18	of	of	ADP
admet-292	1684	19	other	other	ADJ
admet-292	1684	20	techniques	technique	NOUN
admet-292	1684	21	or	or	CCONJ
admet-292	1684	22	to	to	PART
admet-292	1684	23	corroborate	corroborate	VERB
admet-292	1684	24	the	the	DET
admet-292	1684	25	presence	presence	NOUN
admet-292	1684	26	of	of	ADP
admet-292	1684	27	aggregates	aggregate	NOUN
admet-292	1684	28	,	,	PUNCT
admet-292	1684	29	etc	etc	X
admet-292	1684	30	.	.	X
admet-292	1684	31	”	"	PUNCT
admet-292	1685	1	“	"	PUNCT
admet-292	1685	2	intrinsic	intrinsic	ADJ
admet-292	1685	3	solubility	solubility	NOUN
admet-292	1685	4	is	be	AUX
admet-292	1685	5	not	not	PART
admet-292	1685	6	always	always	ADV
admet-292	1685	7	important	important	ADJ
admet-292	1685	8	;	;	PUNCT
admet-292	1685	9	need	need	VERB
admet-292	1685	10	to	to	PART
admet-292	1685	11	know	know	VERB
admet-292	1685	12	solubility	solubility	NOUN
admet-292	1685	13	at	at	ADP
admet-292	1685	14	certain	certain	ADJ
admet-292	1685	15	ph	ph	NOUN
admet-292	1685	16	without	without	ADP
admet-292	1685	17	using	use	VERB
admet-292	1685	18	pka	pka	NOUN
admet-292	1685	19	for	for	ADP
admet-292	1685	20	back	back	NOUN
admet-292	1685	21	-	-	PUNCT
admet-292	1685	22	calculation	calculation	NOUN
admet-292	1685	23	.	.	PUNCT
admet-292	1685	24	”	"	PUNCT
admet-292	1686	1	“	"	PUNCT
admet-292	1686	2	generally	generally	ADV
admet-292	1686	3	:	:	PUNCT
admet-292	1686	4	my	my	PRON
admet-292	1686	5	early	early	ADJ
admet-292	1686	6	-	-	PUNCT
admet-292	1686	7	research	research	NOUN
admet-292	1686	8	group	group	NOUN
admet-292	1686	9	analyzes	analyze	VERB
admet-292	1686	10	15,000	15,000	NUM
admet-292	1686	11	cpds	cpd	NOUN
admet-292	1686	12	/	/	SYM
admet-292	1686	13	annum	annum	NOUN
admet-292	1686	14	in	in	ADP
admet-292	1686	15	a	a	DET
admet-292	1686	16	high	high	ADJ
admet-292	1686	17	throughput	throughput	NOUN
admet-292	1686	18	type	type	NOUN
admet-292	1686	19	assay	assay	NOUN
admet-292	1686	20	(	(	PUNCT
admet-292	1686	21	initial	initial	ADJ
admet-292	1686	22	dissolution	dissolution	NOUN
admet-292	1686	23	in	in	ADP
admet-292	1686	24	dmso	dmso	NOUN
admet-292	1686	25	followed	follow	VERB
admet-292	1686	26	by	by	ADP
admet-292	1686	27	addition	addition	NOUN
admet-292	1686	28	to	to	ADP
admet-292	1686	29	aqueous	aqueous	ADJ
admet-292	1686	30	buffer	buffer	NOUN
admet-292	1686	31	,	,	PUNCT
admet-292	1686	32	24	24	NUM
admet-292	1686	33	h	h	NOUN
admet-292	1686	34	shaking	shake	VERB
admet-292	1686	35	,	,	PUNCT
admet-292	1686	36	filtration	filtration	NOUN
admet-292	1686	37	,	,	PUNCT
admet-292	1686	38	hplc	hplc	NOUN
admet-292	1686	39	)	)	PUNCT
admet-292	1686	40	and	and	CCONJ
admet-292	1686	41	approximately	approximately	ADV
admet-292	1686	42	1000	1000	NUM
admet-292	1686	43	cpds	cpd	NOUN
admet-292	1686	44	/	/	SYM
admet-292	1686	45	annum	annum	NOUN
admet-292	1686	46	in	in	ADP
admet-292	1686	47	a	a	DET
admet-292	1686	48	shake	shake	NOUN
admet-292	1686	49	flask	flask	NOUN
admet-292	1686	50	assay	assay	NOUN
admet-292	1686	51	(	(	PUNCT
admet-292	1686	52	solid	solid	ADJ
admet-292	1686	53	compound	compound	NOUN
admet-292	1686	54	+	+	CCONJ
admet-292	1686	55	buffer	buffer	NOUN
admet-292	1686	56	or	or	CCONJ
admet-292	1686	57	formulary	formulary	NOUN
admet-292	1686	58	solvents	solvent	NOUN
admet-292	1686	59	/	/	SYM
admet-292	1686	60	various	various	ADJ
admet-292	1686	61	phs	phs	NOUN
admet-292	1686	62	)	)	PUNCT
admet-292	1686	63	,	,	PUNCT
admet-292	1686	64	24	24	NUM
admet-292	1686	65	h	h	NOUN
admet-292	1686	66	stirring	stirring	NOUN
admet-292	1686	67	,	,	PUNCT
admet-292	1686	68	centrifugation	centrifugation	NOUN
admet-292	1686	69	,	,	PUNCT
admet-292	1686	70	hplc	hplc	PROPN
admet-292	1686	71	)	)	PUNCT
admet-292	1686	72	.	.	PUNCT
admet-292	1687	1	many	many	ADJ
admet-292	1687	2	of	of	ADP
admet-292	1687	3	the	the	DET
admet-292	1687	4	suggestions	suggestion	NOUN
admet-292	1687	5	given	give	VERB
admet-292	1687	6	in	in	ADP
admet-292	1687	7	the	the	DET
admet-292	1687	8	questionnaire	questionnaire	NOUN
admet-292	1687	9	are	be	AUX
admet-292	1687	10	very	very	ADV
admet-292	1687	11	interesting	interesting	ADJ
admet-292	1687	12	but	but	CCONJ
admet-292	1687	13	definitely	definitely	ADV
admet-292	1687	14	not	not	PART
admet-292	1687	15	feasible	feasible	ADJ
admet-292	1687	16	in	in	ADP
admet-292	1687	17	an	an	DET
admet-292	1687	18	industry	industry	NOUN
admet-292	1687	19	lab	lab	NOUN
admet-292	1687	20	which	which	PRON
admet-292	1687	21	has	have	VERB
admet-292	1687	22	to	to	PART
admet-292	1687	23	provide	provide	VERB
admet-292	1687	24	the	the	DET
admet-292	1687	25	researcher	researcher	NOUN
admet-292	1687	26	with	with	ADP
admet-292	1687	27	data	datum	NOUN
admet-292	1687	28	as	as	ADV
admet-292	1687	29	fast	fast	ADV
admet-292	1687	30	as	as	ADP
admet-292	1687	31	possible	possible	ADJ
admet-292	1687	32	and	and	CCONJ
admet-292	1687	33	as	as	ADV
admet-292	1687	34	accurately	accurately	ADV
admet-292	1687	35	as	as	ADP
admet-292	1687	36	necessary	necessary	ADJ
admet-292	1687	37	.	.	PUNCT
admet-292	1688	1	early	early	ADJ
admet-292	1688	2	solubility	solubility	NOUN
admet-292	1688	3	data	datum	NOUN
admet-292	1688	4	very	very	ADV
admet-292	1688	5	often	often	ADV
admet-292	1688	6	serve	serve	VERB
admet-292	1688	7	as	as	ADP
admet-292	1688	8	estimation	estimation	NOUN
admet-292	1688	9	for	for	ADP
admet-292	1688	10	the	the	DET
admet-292	1688	11	pharmacologist	pharmacologist	NOUN
admet-292	1688	12	and	and	CCONJ
admet-292	1688	13	as	as	ADP
admet-292	1688	14	comparison	comparison	NOUN
admet-292	1688	15	of	of	ADP
admet-292	1688	16	different	different	ADJ
admet-292	1688	17	clusters	cluster	NOUN
admet-292	1688	18	within	within	ADP
admet-292	1688	19	ht	ht	PROPN
admet-292	1688	20	lab	lab	NOUN
admet-292	1688	21	.	.	PUNCT
admet-292	1689	1	they	they	PRON
admet-292	1689	2	do	do	AUX
admet-292	1689	3	n’t	not	PART
admet-292	1689	4	need	need	VERB
admet-292	1689	5	exact	exact	ADJ
admet-292	1689	6	numbers	number	NOUN
admet-292	1689	7	but	but	CCONJ
admet-292	1689	8	rather	rather	ADV
admet-292	1689	9	a	a	DET
admet-292	1689	10	hint	hint	NOUN
admet-292	1689	11	if	if	SCONJ
admet-292	1689	12	the	the	DET
admet-292	1689	13	compound	compound	NOUN
admet-292	1689	14	could	could	AUX
admet-292	1689	15	have	have	VERB
admet-292	1689	16	an	an	DET
admet-292	1689	17	solubility	solubility	NOUN
admet-292	1689	18	issue	issue	NOUN
admet-292	1689	19	during	during	ADP
admet-292	1689	20	further	further	ADJ
admet-292	1689	21	activities	activity	NOUN
admet-292	1689	22	.	.	PUNCT
admet-292	1689	23	”	"	PUNCT
admet-292	1690	1	“	"	PUNCT
admet-292	1690	2	i	i	PRON
admet-292	1690	3	am	be	AUX
admet-292	1690	4	responsible	responsible	ADJ
admet-292	1690	5	for	for	ADP
admet-292	1690	6	the	the	DET
admet-292	1690	7	physchem	physchem	NOUN
admet-292	1690	8	lab	lab	NOUN
admet-292	1690	9	in	in	ADP
admet-292	1690	10	the	the	DET
admet-292	1690	11	medicinal	medicinal	ADJ
admet-292	1690	12	chemistry	chemistry	NOUN
admet-292	1690	13	–	–	PUNCT
admet-292	1690	14	global	global	ADJ
admet-292	1690	15	drug	drug	NOUN
admet-292	1690	16	discovery	discovery	NOUN
admet-292	1690	17	.	.	PUNCT
admet-292	1691	1	we	we	PRON
admet-292	1691	2	have	have	VERB
admet-292	1691	3	to	to	PART
admet-292	1691	4	measure	measure	VERB
admet-292	1691	5	the	the	DET
admet-292	1691	6	solubility	solubility	NOUN
admet-292	1691	7	of	of	ADP
admet-292	1691	8	about	about	ADV
admet-292	1691	9	12,000	12,000	NUM
admet-292	1691	10	new	new	ADJ
admet-292	1691	11	compounds	compound	NOUN
admet-292	1691	12	every	every	DET
admet-292	1691	13	year	year	NOUN
admet-292	1691	14	to	to	PART
admet-292	1691	15	support	support	VERB
admet-292	1691	16	our	our	PRON
admet-292	1691	17	colleagues	colleague	NOUN
admet-292	1691	18	in	in	ADP
admet-292	1691	19	the	the	DET
admet-292	1691	20	different	different	ADJ
admet-292	1691	21	projects	project	NOUN
admet-292	1691	22	.	.	PUNCT
admet-292	1692	1	they	they	PRON
admet-292	1692	2	do	do	AUX
admet-292	1692	3	n’t	not	PART
admet-292	1692	4	need	need	VERB
admet-292	1692	5	absolutely	absolutely	ADV
admet-292	1692	6	exact	exact	ADJ
admet-292	1692	7	solubility	solubility	NOUN
admet-292	1692	8	results	result	NOUN
admet-292	1692	9	at	at	ADP
admet-292	1692	10	this	this	DET
admet-292	1692	11	time	time	NOUN
admet-292	1692	12	of	of	ADP
admet-292	1692	13	research	research	NOUN
admet-292	1692	14	;	;	PUNCT
admet-292	1692	15	they	they	PRON
admet-292	1692	16	need	need	VERB
admet-292	1692	17	the	the	DET
admet-292	1692	18	results	result	NOUN
admet-292	1692	19	very	very	ADV
admet-292	1692	20	fast	fast	ADV
admet-292	1692	21	for	for	ADP
admet-292	1692	22	a	a	DET
admet-292	1692	23	ranking	ranking	NOUN
admet-292	1692	24	between	between	ADP
admet-292	1692	25	the	the	DET
admet-292	1692	26	several	several	ADJ
admet-292	1692	27	compounds	compound	NOUN
admet-292	1692	28	.	.	PUNCT
admet-292	1693	1	thus	thus	ADV
admet-292	1693	2	some	some	PRON
admet-292	1693	3	of	of	ADP
admet-292	1693	4	the	the	DET
admet-292	1693	5	ideas	idea	NOUN
admet-292	1693	6	and	and	CCONJ
admet-292	1693	7	questions	question	NOUN
admet-292	1693	8	below	below	ADV
admet-292	1693	9	are	be	AUX
admet-292	1693	10	very	very	ADV
admet-292	1693	11	good	good	ADJ
admet-292	1693	12	from	from	ADP
admet-292	1693	13	the	the	DET
admet-292	1693	14	scientific	scientific	ADJ
admet-292	1693	15	point	point	NOUN
admet-292	1693	16	of	of	ADP
admet-292	1693	17	view	view	NOUN
admet-292	1693	18	but	but	CCONJ
admet-292	1693	19	not	not	PART
admet-292	1693	20	feasible	feasible	ADJ
admet-292	1693	21	for	for	ADP
admet-292	1693	22	our	our	PRON
admet-292	1693	23	high	high	ADJ
admet-292	1693	24	throughput	throughput	NOUN
admet-292	1693	25	measurements	measurement	NOUN
admet-292	1693	26	.	.	PUNCT
admet-292	1694	1	in	in	ADP
admet-292	1694	2	such	such	ADJ
admet-292	1694	3	cases	case	NOUN
admet-292	1694	4	i	i	PRON
admet-292	1694	5	put	put	VERB
admet-292	1694	6	a	a	DET
admet-292	1694	7	star	star	NOUN
admet-292	1694	8	(	(	PUNCT
admet-292	1694	9	*	*	PUNCT
admet-292	1694	10	)	)	PUNCT
admet-292	1694	11	in	in	ADP
admet-292	1694	12	the	the	DET
admet-292	1694	13	space	space	NOUN
admet-292	1694	14	following	follow	VERB
admet-292	1694	15	the	the	DET
admet-292	1694	16	statement	statement	NOUN
admet-292	1694	17	.	.	PUNCT
admet-292	1694	18	”	"	PUNCT
admet-292	1695	1	“	"	PUNCT
admet-292	1695	2	it	it	PRON
admet-292	1695	3	would	would	AUX
admet-292	1695	4	be	be	AUX
admet-292	1695	5	very	very	ADV
admet-292	1695	6	helpful	helpful	ADJ
admet-292	1695	7	to	to	PART
admet-292	1695	8	have	have	VERB
admet-292	1695	9	two	two	NUM
admet-292	1695	10	kind	kind	NOUN
admet-292	1695	11	of	of	ADP
admet-292	1695	12	operational	operational	ADJ
admet-292	1695	13	suggestions	suggestion	NOUN
admet-292	1695	14	:	:	PUNCT
admet-292	1695	15	(	(	PUNCT
admet-292	1695	16	1	1	X
admet-292	1695	17	)	)	PUNCT
admet-292	1695	18	a	a	DET
admet-292	1695	19	quick	quick	ADJ
admet-292	1695	20	ones	one	NOUN
admet-292	1695	21	for	for	ADP
admet-292	1695	22	a	a	DET
admet-292	1695	23	more	more	ADV
admet-292	1695	24	routine	routine	ADJ
admet-292	1695	25	work	work	NOUN
admet-292	1695	26	;	;	PUNCT
admet-292	1695	27	(	(	PUNCT
admet-292	1695	28	2	2	X
admet-292	1695	29	)	)	PUNCT
admet-292	1695	30	a	a	DET
admet-292	1695	31	more	more	ADV
admet-292	1695	32	complete	complete	ADJ
admet-292	1695	33	suggestions	suggestion	NOUN
admet-292	1695	34	to	to	PART
admet-292	1695	35	be	be	AUX
admet-292	1695	36	applied	apply	VERB
admet-292	1695	37	when	when	SCONJ
admet-292	1695	38	compound	compound	NOUN
admet-292	1695	39	is	be	AUX
admet-292	1695	40	already	already	ADV
admet-292	1695	41	in	in	ADP
admet-292	1695	42	candidate	candidate	NOUN
admet-292	1695	43	profiling	profiling	NOUN
admet-292	1695	44	.	.	PUNCT
admet-292	1696	1	quick	quick	ADJ
admet-292	1696	2	results	result	NOUN
admet-292	1696	3	must	must	AUX
admet-292	1696	4	be	be	AUX
admet-292	1696	5	obtained	obtain	VERB
admet-292	1696	6	at	at	ADP
admet-292	1696	7	the	the	DET
admet-292	1696	8	physchem	physchem	PROPN
admet-292	1696	9	departments	department	NOUN
admet-292	1696	10	in	in	ADP
admet-292	1696	11	the	the	DET
admet-292	1696	12	lead	lead	ADJ
admet-292	1696	13	optimization	optimization	NOUN
admet-292	1696	14	phase	phase	NOUN
admet-292	1696	15	while	while	SCONJ
admet-292	1696	16	in	in	ADP
admet-292	1696	17	the	the	DET
admet-292	1696	18	candidate	candidate	NOUN
admet-292	1696	19	profiling	profiling	NOUN
admet-292	1696	20	more	more	ADJ
admet-292	1696	21	time	time	NOUN
admet-292	1696	22	and	and	CCONJ
admet-292	1696	23	compound	compound	NOUN
admet-292	1696	24	amount	amount	NOUN
admet-292	1696	25	can	can	AUX
admet-292	1696	26	be	be	AUX
admet-292	1696	27	devoted	devote	VERB
admet-292	1696	28	to	to	PART
admet-292	1696	29	study	study	VERB
admet-292	1696	30	the	the	DET
admet-292	1696	31	solubility	solubility	NOUN
admet-292	1696	32	of	of	ADP
admet-292	1696	33	the	the	DET
admet-292	1696	34	compound	compound	NOUN
admet-292	1696	35	.	.	PUNCT
admet-292	1696	36	”	"	PUNCT
admet-292	1697	1	“	"	PUNCT
admet-292	1697	2	although	although	SCONJ
admet-292	1697	3	we	we	PRON
admet-292	1697	4	are	be	AUX
admet-292	1697	5	measuring	measure	VERB
admet-292	1697	6	ht	ht	PROPN
admet-292	1697	7	solubility	solubility	NOUN
admet-292	1697	8	in	in	ADP
admet-292	1697	9	a	a	DET
admet-292	1697	10	pragmatic	pragmatic	ADJ
admet-292	1697	11	way	way	NOUN
admet-292	1697	12	(	(	PUNCT
admet-292	1697	13	dmso	dmso	NOUN
admet-292	1697	14	5	5	NUM
admet-292	1697	15	%	%	NOUN
admet-292	1697	16	precipitative	precipitative	ADJ
admet-292	1697	17	solubility	solubility	NOUN
admet-292	1697	18	)	)	PUNCT
admet-292	1697	19	,	,	PUNCT
admet-292	1697	20	[	[	X
admet-292	1697	21	such	such	ADJ
admet-292	1697	22	measurements	measurement	NOUN
admet-292	1697	23	]	]	PUNCT
admet-292	1697	24	are	be	AUX
admet-292	1697	25	still	still	ADV
admet-292	1697	26	useful	useful	ADJ
admet-292	1697	27	in	in	ADP
admet-292	1697	28	drug	drug	NOUN
admet-292	1697	29	discovery	discovery	NOUN
admet-292	1697	30	.	.	PUNCT
admet-292	1698	1	we	we	PRON
admet-292	1698	2	can	can	AUX
admet-292	1698	3	select	select	VERB
admet-292	1698	4	the	the	DET
admet-292	1698	5	most	most	ADV
admet-292	1698	6	soluble	soluble	ADJ
admet-292	1698	7	series	series	NOUN
admet-292	1698	8	,	,	PUNCT
admet-292	1698	9	we	we	PRON
admet-292	1698	10	could	could	AUX
admet-292	1698	11	even	even	ADV
admet-292	1698	12	build	build	VERB
admet-292	1698	13	some	some	DET
admet-292	1698	14	sort	sort	NOUN
admet-292	1698	15	of	of	ADV
admet-292	1698	16	in	in	ADP
admet-292	1698	17	silico	silico	NOUN
admet-292	1698	18	guide	guide	NOUN
admet-292	1698	19	for	for	ADP
admet-292	1698	20	chemists	chemist	NOUN
admet-292	1698	21	using	use	VERB
admet-292	1698	22	half	half	DET
admet-292	1698	23	a	a	DET
admet-292	1698	24	million	million	NUM
admet-292	1698	25	compounds	compound	NOUN
admet-292	1698	26	’	'	PUNCT
admet-292	1698	27	solubility	solubility	NOUN
admet-292	1698	28	data	datum	NOUN
admet-292	1698	29	(	(	PUNCT
admet-292	1698	30	ph	ph	NOUN
admet-292	1698	31	7.4	7.4	NUM
admet-292	1698	32	,	,	PUNCT
admet-292	1698	33	1	1	NUM
admet-292	1698	34	h	h	NOUN
admet-292	1698	35	equilibration	equilibration	NOUN
admet-292	1698	36	0.1	0.1	NUM
admet-292	1698	37	m	m	NOUN
admet-292	1698	38	phosphate	phosphate	ADJ
admet-292	1698	39	buffer	buffer	NOUN
admet-292	1698	40	)	)	PUNCT
admet-292	1698	41	expressed	express	VERB
admet-292	1698	42	in	in	ADP
admet-292	1698	43	molar	molar	ADJ
admet-292	1698	44	term	term	NOUN
admet-292	1698	45	using	use	VERB
admet-292	1698	46	the	the	DET
admet-292	1698	47	matched	match	VERB
admet-292	1698	48	molecular	molecular	ADJ
admet-292	1698	49	pairs	pair	NOUN
admet-292	1698	50	approach	approach	NOUN
admet-292	1698	51	.	.	PUNCT
admet-292	1699	1	so	so	ADV
admet-292	1699	2	we	we	PRON
admet-292	1699	3	have	have	VERB
admet-292	1699	4	a	a	DET
admet-292	1699	5	long	long	ADJ
admet-292	1699	6	lists	list	NOUN
admet-292	1699	7	of	of	ADP
admet-292	1699	8	substituents	substituent	NOUN
admet-292	1699	9	with	with	ADP
admet-292	1699	10	the	the	DET
admet-292	1699	11	average	average	ADJ
admet-292	1699	12	contribution	contribution	NOUN
admet-292	1699	13	to	to	ADP
admet-292	1699	14	solubility	solubility	NOUN
admet-292	1699	15	(	(	PUNCT
admet-292	1699	16	enhance	enhance	VERB
admet-292	1699	17	or	or	CCONJ
admet-292	1699	18	reduce	reduce	VERB
admet-292	1699	19	)	)	PUNCT
admet-292	1699	20	and	and	CCONJ
admet-292	1699	21	its	its	PRON
admet-292	1699	22	standard	standard	ADJ
admet-292	1699	23	deviations	deviation	NOUN
admet-292	1699	24	.	.	PUNCT
admet-292	1700	1	the	the	DET
admet-292	1700	2	pharmaceutical	pharmaceutical	NOUN
admet-292	1700	3	industry	industry	NOUN
admet-292	1700	4	is	be	AUX
admet-292	1700	5	interested	interested	ADJ
admet-292	1700	6	in	in	ADP
admet-292	1700	7	measuring	measure	VERB
admet-292	1700	8	solubility	solubility	NOUN
admet-292	1700	9	in	in	ADP
admet-292	1700	10	various	various	ADJ
admet-292	1700	11	bio	bio	ADJ
admet-292	1700	12	-	-	ADJ
admet-292	1700	13	relevant	relevant	ADJ
admet-292	1700	14	media	medium	NOUN
admet-292	1700	15	such	such	ADJ
admet-292	1700	16	as	as	ADP
admet-292	1700	17	simulated	simulate	VERB
admet-292	1700	18	lung	lung	NOUN
admet-292	1700	19	fluid	fluid	NOUN
admet-292	1700	20	,	,	PUNCT
admet-292	1700	21	simulated	simulate	VERB
admet-292	1700	22	intestinal	intestinal	ADJ
admet-292	1700	23	fluid	fluid	NOUN
admet-292	1700	24	,	,	PUNCT
admet-292	1700	25	etc	etc	X
admet-292	1700	26	.	.	X
admet-292	1701	1	i	i	PRON
admet-292	1701	2	think	think	VERB
admet-292	1701	3	even	even	ADV
admet-292	1701	4	for	for	ADP
admet-292	1701	5	those	those	DET
admet-292	1701	6	measurements	measurement	NOUN
admet-292	1701	7	the	the	DET
admet-292	1701	8	ph	ph	ADJ
admet-292	1701	9	,	,	PUNCT
admet-292	1701	10	solid	solid	ADJ
admet-292	1701	11	form	form	NOUN
admet-292	1701	12	characterization	characterization	NOUN
admet-292	1701	13	,	,	PUNCT
admet-292	1701	14	temperature	temperature	NOUN
admet-292	1701	15	etc	etc	X
admet-292	1701	16	are	be	AUX
admet-292	1701	17	important	important	ADJ
admet-292	1701	18	details	detail	NOUN
admet-292	1701	19	to	to	PART
admet-292	1701	20	provide	provide	VERB
admet-292	1701	21	.	.	PUNCT
admet-292	1702	1	overall	overall	ADV
admet-292	1702	2	,	,	PUNCT
admet-292	1702	3	it	it	PRON
admet-292	1702	4	was	be	AUX
admet-292	1702	5	an	an	DET
admet-292	1702	6	exciting	exciting	ADJ
admet-292	1702	7	session	session	NOUN
admet-292	1702	8	and	and	CCONJ
admet-292	1702	9	i	i	PRON
admet-292	1702	10	was	be	AUX
admet-292	1702	11	amazed	amazed	ADJ
admet-292	1702	12	how	how	SCONJ
admet-292	1702	13	many	many	ADJ
admet-292	1702	14	people	people	NOUN
admet-292	1702	15	were	be	AUX
admet-292	1702	16	there	there	ADV
admet-292	1702	17	until	until	ADP
admet-292	1702	18	nearly	nearly	ADV
admet-292	1702	19	midnight	midnight	NOUN
admet-292	1702	20	!	!	PUNCT
admet-292	1702	21	”	"	PUNCT
admet-292	1703	1	“	"	PUNCT
admet-292	1703	2	solubility	solubility	NOUN
admet-292	1703	3	measurement	measurement	NOUN
admet-292	1703	4	methodology	methodology	NOUN
admet-292	1703	5	depends	depend	VERB
admet-292	1703	6	on	on	ADP
admet-292	1703	7	sample	sample	NOUN
admet-292	1703	8	quantity	quantity	NOUN
admet-292	1703	9	availability	availability	NOUN
admet-292	1703	10	,	,	PUNCT
admet-292	1703	11	precision	precision	NOUN
admet-292	1703	12	of	of	ADP
admet-292	1703	13	measurement	measurement	NOUN
admet-292	1703	14	and	and	CCONJ
admet-292	1703	15	characteristics	characteristic	NOUN
admet-292	1703	16	of	of	ADP
admet-292	1703	17	the	the	DET
admet-292	1703	18	drug	drug	NOUN
admet-292	1703	19	molecule	molecule	NOUN
admet-292	1703	20	(	(	PUNCT
admet-292	1703	21	purity	purity	NOUN
admet-292	1703	22	,	,	PUNCT
admet-292	1703	23	solid	solid	ADJ
admet-292	1703	24	state	state	NOUN
admet-292	1703	25	properties	property	NOUN
admet-292	1703	26	)	)	PUNCT
admet-292	1703	27	.	.	PUNCT
admet-292	1703	28	”	"	PUNCT
admet-292	1704	1	“	"	PUNCT
admet-292	1704	2	[	[	X
admet-292	1704	3	reporting	reporting	NOUN
admet-292	1704	4	]	]	PUNCT
admet-292	1704	5	the	the	DET
admet-292	1704	6	amount	amount	NOUN
admet-292	1704	7	of	of	ADP
admet-292	1704	8	solid	solid	ADJ
admet-292	1704	9	in	in	ADP
admet-292	1704	10	excess	excess	NOUN
admet-292	1704	11	is	be	AUX
admet-292	1704	12	important	important	ADJ
admet-292	1704	13	,	,	PUNCT
admet-292	1704	14	especially	especially	ADV
admet-292	1704	15	when	when	SCONJ
admet-292	1704	16	the	the	DET
admet-292	1704	17	solid	solid	NOUN
admet-292	1704	18	is	be	AUX
admet-292	1704	19	a	a	DET
admet-292	1704	20	salt	salt	NOUN
admet-292	1704	21	,	,	PUNCT
admet-292	1704	22	as	as	SCONJ
admet-292	1704	23	the	the	DET
admet-292	1704	24	counterion	counterion	NOUN
admet-292	1704	25	may	may	AUX
admet-292	1704	26	affect	affect	VERB
admet-292	1704	27	ph	ph	NOUN
admet-292	1704	28	of	of	ADP
admet-292	1704	29	the	the	DET
admet-292	1704	30	solution	solution	NOUN
admet-292	1704	31	significantly	significantly	ADV
admet-292	1704	32	.	.	PUNCT
admet-292	1704	33	”	"	PUNCT
admet-292	1705	1	“	"	PUNCT
admet-292	1705	2	shaking	shake	VERB
admet-292	1705	3	intensity	intensity	NOUN
admet-292	1705	4	may	may	AUX
admet-292	1705	5	be	be	AUX
admet-292	1705	6	more	more	ADV
admet-292	1705	7	important	important	ADJ
admet-292	1705	8	than	than	ADP
admet-292	1705	9	time	time	NOUN
admet-292	1705	10	of	of	ADP
admet-292	1705	11	incubation	incubation	NOUN
admet-292	1705	12	.	.	PUNCT
admet-292	1705	13	”	"	PUNCT
admet-292	1706	1	admet	admet	PROPN
admet-292	1706	2	&	&	CCONJ
admet-292	1706	3	dmpk	dmpk	PROPN
admet-292	1706	4	4(2	4(2	NUM
admet-292	1706	5	)	)	PUNCT
admet-292	1706	6	(	(	PUNCT
admet-292	1706	7	2016	2016	NUM
admet-292	1706	8	)	)	PUNCT
admet-292	1706	9	117	117	NUM
admet-292	1706	10	-	-	SYM
admet-292	1706	11	178	178	NUM
admet-292	1706	12	consensus	consensus	NOUN
admet-292	1706	13	recommendations	recommendation	NOUN
admet-292	1706	14	for	for	ADP
admet-292	1706	15	improving	improve	VERB
admet-292	1706	16	solubility	solubility	NOUN
admet-292	1706	17	-	-	PUNCT
admet-292	1706	18	ph	ph	ADJ
admet-292	1706	19	data	datum	NOUN
admet-292	1706	20	quality	quality	NOUN
admet-292	1706	21	doi	doi	NOUN
admet-292	1706	22	:	:	PUNCT
admet-292	1706	23	10.5599	10.5599	NUM
admet-292	1706	24	/	/	SYM
admet-292	1706	25	admet.4.2.292	admet.4.2.292	NUM
admet-292	1706	26	175	175	NUM
admet-292	1706	27	“	"	PUNCT
admet-292	1706	28	i	i	PRON
admet-292	1706	29	do	do	AUX
admet-292	1706	30	not	not	PART
admet-292	1706	31	like	like	VERB
admet-292	1706	32	people	people	NOUN
admet-292	1706	33	saying	say	VERB
admet-292	1706	34	"	"	PUNCT
admet-292	1706	35	24	24	NUM
admet-292	1706	36	h	h	NOUN
admet-292	1706	37	"	"	PUNCT
admet-292	1707	1	[	[	X
admet-292	1707	2	incubation	incubation	NOUN
admet-292	1707	3	time	time	NOUN
admet-292	1707	4	]	]	PUNCT
admet-292	1707	5	.	.	PUNCT
admet-292	1708	1	we	we	PRON
admet-292	1708	2	have	have	AUX
admet-292	1708	3	reached	reach	VERB
admet-292	1708	4	equilibrium	equilibrium	NOUN
admet-292	1708	5	at	at	ADP
admet-292	1708	6	4	4	NUM
admet-292	1708	7	h	h	NOUN
admet-292	1708	8	in	in	ADP
admet-292	1708	9	some	some	DET
admet-292	1708	10	cases	case	NOUN
admet-292	1708	11	.	.	PUNCT
admet-292	1709	1	“	"	PUNCT
admet-292	1709	2	i	i	PRON
admet-292	1709	3	was	be	AUX
admet-292	1709	4	really	really	ADV
admet-292	1709	5	interested	interested	ADJ
admet-292	1709	6	in	in	ADP
admet-292	1709	7	learning	learn	VERB
admet-292	1709	8	yesterday	yesterday	NOUN
admet-292	1709	9	on	on	ADP
admet-292	1709	10	the	the	DET
admet-292	1709	11	importance	importance	NOUN
admet-292	1709	12	of	of	ADP
admet-292	1709	13	sedimentation	sedimentation	NOUN
admet-292	1709	14	on	on	ADP
admet-292	1709	15	solubility	solubility	NOUN
admet-292	1709	16	measurements	measurement	NOUN
admet-292	1709	17	.	.	PUNCT
admet-292	1710	1	if	if	SCONJ
admet-292	1710	2	you	you	PRON
admet-292	1710	3	have	have	VERB
admet-292	1710	4	a	a	DET
admet-292	1710	5	relevant	relevant	ADJ
admet-292	1710	6	paper	paper	NOUN
admet-292	1710	7	please	please	INTJ
admet-292	1710	8	could	could	AUX
admet-292	1710	9	you	you	PRON
admet-292	1710	10	send	send	VERB
admet-292	1710	11	it	it	PRON
admet-292	1710	12	to	to	ADP
admet-292	1710	13	me	i	PRON
admet-292	1710	14	?	?	PUNCT
admet-292	1710	15	”	"	PUNCT
admet-292	1711	1	“	"	PUNCT
admet-292	1711	2	buffer	buffer	VERB
admet-292	1711	3	species	specie	NOUN
admet-292	1711	4	identity	identity	NOUN
admet-292	1711	5	:	:	PUNCT
admet-292	1711	6	we	we	PRON
admet-292	1711	7	have	have	AUX
admet-292	1711	8	actually	actually	ADV
admet-292	1711	9	observed	observe	VERB
admet-292	1711	10	effects	effect	NOUN
admet-292	1711	11	(	(	PUNCT
admet-292	1711	12	vertzoni	vertzoni	NOUN
admet-292	1711	13	et	et	PROPN
admet-292	1711	14	al	al	PROPN
admet-292	1711	15	.	.	PROPN
admet-292	1711	16	jpp	jpp	PROPN
admet-292	1711	17	,	,	PUNCT
admet-292	1711	18	2004	2004	NUM
admet-292	1711	19	)	)	PUNCT
admet-292	1711	20	when	when	SCONJ
admet-292	1711	21	the	the	DET
admet-292	1711	22	api	api	NOUN
admet-292	1711	23	(	(	PUNCT
admet-292	1711	24	if	if	SCONJ
admet-292	1711	25	ionized	ionize	VERB
admet-292	1711	26	)	)	PUNCT
admet-292	1711	27	interacts	interact	VERB
admet-292	1711	28	with	with	ADP
admet-292	1711	29	the	the	DET
admet-292	1711	30	oppositely	oppositely	ADV
admet-292	1711	31	charged	charge	VERB
admet-292	1711	32	(	(	PUNCT
admet-292	1711	33	?	?	PUNCT
admet-292	1711	34	)	)	PUNCT
admet-292	1711	35	species	specie	NOUN
admet-292	1711	36	of	of	ADP
admet-292	1711	37	the	the	DET
admet-292	1711	38	buffer	buffer	NOUN
admet-292	1711	39	system	system	NOUN
admet-292	1711	40	.	.	PUNCT
admet-292	1711	41	”	"	PUNCT
admet-292	1712	1	extra	extra	ADJ
admet-292	1712	2	topic	topic	NOUN
admet-292	1712	3	questions	question	NOUN
admet-292	1712	4	describe	describe	VERB
admet-292	1712	5	how	how	SCONJ
admet-292	1712	6	you	you	PRON
admet-292	1712	7	handle	handle	VERB
admet-292	1712	8	the	the	DET
admet-292	1712	9	following	follow	VERB
admet-292	1712	10	potential	potential	ADJ
admet-292	1712	11	challenges	challenge	NOUN
admet-292	1712	12			VERB
admet-292	1712	13	poor	poor	ADJ
admet-292	1712	14	wettability	wettability	NOUN
admet-292	1712	15	“	"	PUNCT
admet-292	1712	16	high	high	ADJ
admet-292	1712	17	stirring	stirring	NOUN
admet-292	1712	18	power	power	NOUN
admet-292	1712	19	during	during	ADP
admet-292	1712	20	a	a	DET
admet-292	1712	21	long	long	ADJ
admet-292	1712	22	time	time	NOUN
admet-292	1712	23	.	.	PUNCT
admet-292	1712	24	”	"	PUNCT
admet-292	1713	1			PROPN
admet-292	1713	2	adding	add	VERB
admet-292	1713	3	a	a	DET
admet-292	1713	4	very	very	ADV
admet-292	1713	5	small	small	ADJ
admet-292	1713	6	weight	weight	NOUN
admet-292	1713	7	(	(	PUNCT
admet-292	1713	8	e.g.	e.g.	ADV
admet-292	1713	9	,	,	PUNCT
admet-292	1713	10	1	1	NUM
admet-292	1713	11	–	–	SYM
admet-292	1713	12	10	10	NUM
admet-292	1713	13	μg	μg	NOUN
admet-292	1713	14	)	)	PUNCT
admet-292	1713	15	of	of	ADP
admet-292	1713	16	drug	drug	NOUN
admet-292	1713	17	to	to	ADP
admet-292	1713	18	a	a	DET
admet-292	1713	19	vial	vial	ADJ
admet-292	1713	20	[	[	X
admet-292	1713	21	no	no	DET
admet-292	1713	22	comments	comment	NOUN
admet-292	1713	23	.	.	PUNCT
admet-292	1713	24	]	]	PUNCT
admet-292	1714	1			ADJ
admet-292	1714	2	formation	formation	NOUN
admet-292	1714	3	of	of	ADP
admet-292	1714	4	drug	drug	NOUN
admet-292	1714	5	aggr./oligomers	aggr./oligomer	NOUN
admet-292	1714	6	(	(	PUNCT
admet-292	1714	7	dimers	dimer	NOUN
admet-292	1714	8	,	,	PUNCT
admet-292	1714	9	trimers	trimer	NOUN
admet-292	1714	10	,	,	PUNCT
admet-292	1714	11	…	…	PUNCT
admet-292	1714	12	)	)	PUNCT
admet-292	1714	13	,	,	PUNCT
admet-292	1714	14	micelles	micelle	NOUN
admet-292	1714	15	,	,	PUNCT
admet-292	1714	16	or	or	CCONJ
admet-292	1714	17	drug	drug	NOUN
admet-292	1714	18	-	-	PUNCT
admet-292	1714	19	buffer	buffer	NOUN
admet-292	1714	20	complexes	complex	NOUN
admet-292	1714	21	“	"	PUNCT
admet-292	1714	22	shake	shake	VERB
admet-292	1714	23	-	-	PUNCT
admet-292	1714	24	flask	flask	NOUN
admet-292	1714	25	s	s	ADJ
admet-292	1714	26	-	-	PUNCT
admet-292	1714	27	ph	ph	ADJ
admet-292	1714	28	profiles	profile	NOUN
admet-292	1714	29	”	"	PUNCT
admet-292	1714	30			ADJ
admet-292	1714	31	formation	formation	NOUN
admet-292	1714	32	of	of	ADP
admet-292	1714	33	ion	ion	NOUN
admet-292	1714	34	-	-	PUNCT
admet-292	1714	35	pair	pair	NOUN
admet-292	1714	36	between	between	ADP
admet-292	1714	37	ionic	ionic	ADJ
admet-292	1714	38	str	str	NOUN
admet-292	1714	39	.	.	PUNCT
admet-292	1715	1	adjustor	adjustor	NOUN
admet-292	1715	2	(	(	PUNCT
admet-292	1715	3	e.g.	e.g.	ADV
admet-292	1715	4	,	,	PUNCT
admet-292	1715	5	nacl	nacl	NOUN
admet-292	1715	6	,	,	PUNCT
admet-292	1715	7	etc	etc	X
admet-292	1715	8	.	.	X
admet-292	1715	9	)	)	PUNCT
admet-292	1716	1	and	and	CCONJ
admet-292	1716	2	charged	charge	VERB
admet-292	1716	3	form	form	NOUN
admet-292	1716	4	of	of	ADP
admet-292	1716	5	drug	drug	NOUN
admet-292	1716	6	“	"	PUNCT
admet-292	1716	7	shake	shake	VERB
admet-292	1716	8	-	-	PUNCT
admet-292	1716	9	flask	flask	NOUN
admet-292	1716	10	s	s	ADJ
admet-292	1716	11	-	-	PUNCT
admet-292	1716	12	ph	ph	ADJ
admet-292	1716	13	profiles	profile	NOUN
admet-292	1716	14	”	"	PUNCT
admet-292	1716	15			ADJ
admet-292	1716	16	effect	effect	NOUN
admet-292	1716	17	of	of	ADP
admet-292	1716	18	impurities	impurity	NOUN
admet-292	1716	19	,	,	PUNCT
admet-292	1716	20	especially	especially	ADV
admet-292	1716	21	those	those	PRON
admet-292	1716	22	which	which	PRON
admet-292	1716	23	are	be	AUX
admet-292	1716	24	ionizable	ionizable	ADJ
admet-292	1716	25	“	"	PUNCT
admet-292	1716	26	not	not	PART
admet-292	1716	27	contemplated	contemplate	VERB
admet-292	1716	28	”	"	PUNCT
admet-292	1716	29			PROPN
admet-292	1716	30	compound	compound	NOUN
admet-292	1716	31	decomposition	decomposition	NOUN
admet-292	1716	32	at	at	ADP
admet-292	1716	33	the	the	DET
admet-292	1716	34	extremes	extreme	NOUN
admet-292	1716	35	of	of	ADP
admet-292	1716	36	ph	ph	PROPN
admet-292	1716	37	or	or	CCONJ
admet-292	1716	38	over	over	ADP
admet-292	1716	39	long	long	ADJ
admet-292	1716	40	saturation	saturation	NOUN
admet-292	1716	41	times	time	NOUN
admet-292	1716	42	“	"	PUNCT
admet-292	1716	43	hplc	hplc	NOUN
admet-292	1716	44	measurements	measurement	NOUN
admet-292	1716	45	provide	provide	VERB
admet-292	1716	46	an	an	DET
admet-292	1716	47	idea	idea	NOUN
admet-292	1716	48	of	of	ADP
admet-292	1716	49	decomposition	decomposition	NOUN
admet-292	1716	50	,	,	PUNCT
admet-292	1716	51	so	so	CCONJ
admet-292	1716	52	we	we	PRON
admet-292	1716	53	know	know	VERB
admet-292	1716	54	that	that	SCONJ
admet-292	1716	55	additional	additional	ADJ
admet-292	1716	56	processes	process	NOUN
admet-292	1716	57	occur	occur	VERB
admet-292	1716	58	at	at	ADP
admet-292	1716	59	that	that	DET
admet-292	1716	60	ph	ph	ADJ
admet-292	1716	61	values	value	NOUN
admet-292	1716	62	.	.	PUNCT
admet-292	1716	63	”	"	PUNCT
admet-292	1717	1			ADJ
admet-292	1717	2	sensitivity	sensitivity	NOUN
admet-292	1717	3	of	of	ADP
admet-292	1717	4	analytical	analytical	ADJ
admet-292	1717	5	methods	method	NOUN
admet-292	1717	6	(	(	PUNCT
admet-292	1717	7	which	which	PRON
admet-292	1717	8	do	do	AUX
admet-292	1717	9	you	you	PRON
admet-292	1717	10	use	use	VERB
admet-292	1717	11	?	?	PUNCT
admet-292	1717	12	)	)	PUNCT
admet-292	1717	13	to	to	PART
admet-292	1717	14	determine	determine	VERB
admet-292	1717	15	very	very	ADV
admet-292	1717	16	low	low	ADJ
admet-292	1717	17	drug	drug	NOUN
admet-292	1717	18	concentration	concentration	NOUN
admet-292	1717	19	“	"	PUNCT
admet-292	1717	20	hplc	hplc	NOUN
admet-292	1717	21	”	"	PUNCT
admet-292	1717	22	q&a	q&a	PROPN
admet-292	1717	23	blog	blog	NOUN
admet-292	1717	24	q	q	NOUN
admet-292	1717	25	:	:	PUNCT
admet-292	1717	26	firstly	firstly	ADV
admet-292	1717	27	,	,	PUNCT
admet-292	1717	28	i	i	PRON
admet-292	1717	29	remember	remember	VERB
admet-292	1717	30	that	that	SCONJ
admet-292	1717	31	someone	someone	PRON
admet-292	1717	32	said	say	VERB
admet-292	1717	33	at	at	ADP
admet-292	1717	34	the	the	DET
admet-292	1717	35	conference	conference	NOUN
admet-292	1717	36	that	that	SCONJ
admet-292	1717	37	an	an	DET
admet-292	1717	38	ultrasonic	ultrasonic	ADJ
admet-292	1717	39	bath	bath	NOUN
admet-292	1717	40	can	can	AUX
admet-292	1717	41	be	be	AUX
admet-292	1717	42	used	use	VERB
admet-292	1717	43	for	for	ADP
admet-292	1717	44	stirring	stirring	NOUN
admet-292	1717	45	/	/	SYM
admet-292	1717	46	mixing	mixing	NOUN
admet-292	1717	47	during	during	ADP
admet-292	1717	48	the	the	DET
admet-292	1717	49	solubility	solubility	NOUN
admet-292	1717	50	assay	assay	VERB
admet-292	1717	51	.	.	PUNCT
admet-292	1718	1	is	be	AUX
admet-292	1718	2	the	the	DET
admet-292	1718	3	ultrasonic	ultrasonic	ADJ
admet-292	1718	4	bath	bath	NOUN
admet-292	1718	5	a	a	DET
admet-292	1718	6	good	good	ADJ
admet-292	1718	7	option	option	NOUN
admet-292	1718	8	for	for	ADP
admet-292	1718	9	dissolving	dissolve	VERB
admet-292	1718	10	compounds	compound	NOUN
admet-292	1718	11	over	over	ADP
admet-292	1718	12	6	6	NUM
admet-292	1718	13	h	h	NOUN
admet-292	1718	14	,	,	PUNCT
admet-292	1718	15	or	or	CCONJ
admet-292	1718	16	is	be	AUX
admet-292	1718	17	it	it	PRON
admet-292	1718	18	better	well	ADJ
admet-292	1718	19	to	to	PART
admet-292	1718	20	do	do	VERB
admet-292	1718	21	some	some	DET
admet-292	1718	22	stirring	stirring	NOUN
admet-292	1718	23	in	in	ADP
admet-292	1718	24	the	the	DET
admet-292	1718	25	assays	assay	NOUN
admet-292	1718	26	?	?	PUNCT
admet-292	1719	1	an	an	DET
admet-292	1719	2	ultrasonic	ultrasonic	ADJ
admet-292	1719	3	bath	bath	NOUN
admet-292	1719	4	could	could	AUX
admet-292	1719	5	be	be	AUX
admet-292	1719	6	an	an	DET
admet-292	1719	7	aggressive	aggressive	ADJ
admet-292	1719	8	way	way	NOUN
admet-292	1719	9	to	to	PART
admet-292	1719	10	dissolve	dissolve	VERB
admet-292	1719	11	compounds	compound	NOUN
admet-292	1719	12	,	,	PUNCT
admet-292	1719	13	to	to	PART
admet-292	1719	14	shorten	shorten	VERB
admet-292	1719	15	subsequent	subsequent	ADJ
admet-292	1719	16	stirring	stirring	NOUN
admet-292	1719	17	time	time	NOUN
admet-292	1719	18	.	.	PUNCT
admet-292	1720	1	no	no	DET
admet-292	1720	2	problems	problem	NOUN
admet-292	1720	3	with	with	ADP
admet-292	1720	4	wetting	wetting	NOUN
admet-292	1720	5	should	should	AUX
admet-292	1720	6	exist	exist	VERB
admet-292	1720	7	.	.	PUNCT
admet-292	1721	1	is	be	AUX
admet-292	1721	2	it	it	PRON
admet-292	1721	3	true	true	ADJ
admet-292	1721	4	?	?	PUNCT
admet-292	1722	1	a1	a1	NOUN
admet-292	1722	2	:	:	PUNCT
admet-292	1722	3	my	my	PRON
admet-292	1722	4	guess	guess	NOUN
admet-292	1722	5	is	be	AUX
admet-292	1722	6	that	that	SCONJ
admet-292	1722	7	some	some	PRON
admet-292	1722	8	would	would	AUX
admet-292	1722	9	think	think	VERB
admet-292	1722	10	that	that	SCONJ
admet-292	1722	11	sonic	sonic	ADJ
admet-292	1722	12	stirring	stirring	NOUN
admet-292	1722	13	might	might	AUX
admet-292	1722	14	create	create	VERB
admet-292	1722	15	a	a	DET
admet-292	1722	16	system	system	NOUN
admet-292	1722	17	that	that	PRON
admet-292	1722	18	is	be	AUX
admet-292	1722	19	supersaturated	supersaturate	VERB
admet-292	1722	20	(	(	PUNCT
admet-292	1722	21	if	if	SCONJ
admet-292	1722	22	the	the	DET
admet-292	1722	23	starting	starting	NOUN
admet-292	1722	24	material	material	NOUN
admet-292	1722	25	is	be	AUX
admet-292	1722	26	a	a	DET
admet-292	1722	27	salt	salt	NOUN
admet-292	1722	28	of	of	ADP
admet-292	1722	29	the	the	DET
admet-292	1722	30	drug	drug	NOUN
admet-292	1722	31	)	)	PUNCT
admet-292	1722	32	.	.	PUNCT
admet-292	1723	1	the	the	DET
admet-292	1723	2	sedimentation	sedimentation	NOUN
admet-292	1723	3	period	period	NOUN
admet-292	1723	4	should	should	AUX
admet-292	1723	5	help	help	VERB
admet-292	1723	6	the	the	DET
admet-292	1723	7	suspension	suspension	NOUN
admet-292	1723	8	to	to	PART
admet-292	1723	9	go	go	VERB
admet-292	1723	10	in	in	ADP
admet-292	1723	11	the	the	DET
admet-292	1723	12	direction	direction	NOUN
admet-292	1723	13	of	of	ADP
admet-292	1723	14	equilibrium	equilibrium	NOUN
admet-292	1723	15	.	.	PUNCT
admet-292	1724	1	wetting	wet	VERB
admet-292	1724	2	could	could	AUX
admet-292	1724	3	make	make	VERB
admet-292	1724	4	the	the	DET
admet-292	1724	5	sonic	sonic	ADJ
admet-292	1724	6	agitation	agitation	NOUN
admet-292	1724	7	problematic	problematic	ADJ
admet-292	1724	8	.	.	PUNCT
admet-292	1725	1	(	(	PUNCT
admet-292	1725	2	not	not	PART
admet-292	1725	3	sure	sure	ADJ
admet-292	1725	4	.	.	PUNCT
admet-292	1725	5	)	)	PUNCT
admet-292	1726	1	a2	a2	PROPN
admet-292	1726	2	:	:	PUNCT
admet-292	1727	1	i	i	PRON
admet-292	1727	2	do	do	AUX
admet-292	1727	3	not	not	PART
admet-292	1727	4	recommend	recommend	VERB
admet-292	1727	5	it	it	PRON
admet-292	1727	6	.	.	PUNCT
admet-292	1728	1	if	if	SCONJ
admet-292	1728	2	the	the	DET
admet-292	1728	3	compound	compound	NOUN
admet-292	1728	4	is	be	AUX
admet-292	1728	5	poorly	poorly	ADV
admet-292	1728	6	wettable	wettable	ADJ
admet-292	1728	7	,	,	PUNCT
admet-292	1728	8	the	the	DET
admet-292	1728	9	sonication	sonication	NOUN
admet-292	1728	10	will	will	AUX
admet-292	1728	11	drive	drive	VERB
admet-292	1728	12	the	the	DET
admet-292	1728	13	solid	solid	NOUN
admet-292	1728	14	out	out	ADP
admet-292	1728	15	to	to	ADP
admet-292	1728	16	the	the	DET
admet-292	1728	17	surface	surface	NOUN
admet-292	1728	18	of	of	ADP
admet-292	1728	19	the	the	DET
admet-292	1728	20	flask	flask	NOUN
admet-292	1728	21	.	.	PUNCT
admet-292	1729	1	q	q	X
admet-292	1729	2	:	:	PUNCT
admet-292	1729	3	one	one	NUM
admet-292	1729	4	question	question	NOUN
admet-292	1729	5	is	be	AUX
admet-292	1729	6	about	about	SCONJ
admet-292	1729	7	basics	basic	NOUN
admet-292	1729	8	of	of	ADP
admet-292	1729	9	solubility	solubility	NOUN
admet-292	1729	10	assay	assay	VERB
admet-292	1729	11	.	.	PUNCT
admet-292	1730	1	i	i	PRON
admet-292	1730	2	have	have	AUX
admet-292	1730	3	planned	plan	VERB
admet-292	1730	4	that	that	SCONJ
admet-292	1730	5	i	i	PRON
admet-292	1730	6	will	will	AUX
admet-292	1730	7	add	add	VERB
admet-292	1730	8	certain	certain	ADJ
admet-292	1730	9	amount	amount	NOUN
admet-292	1730	10	of	of	ADP
admet-292	1730	11	compound	compound	NOUN
admet-292	1730	12	in	in	ADP
admet-292	1730	13	vial	vial	ADJ
admet-292	1730	14	and	and	CCONJ
admet-292	1730	15	then	then	ADV
admet-292	1730	16	add	add	VERB
admet-292	1730	17	buffer	buffer	NOUN
admet-292	1730	18	.	.	PUNCT
admet-292	1731	1	after	after	ADP
admet-292	1731	2	this	this	PRON
admet-292	1731	3	when	when	SCONJ
admet-292	1731	4	no	no	DET
admet-292	1731	5	precipitate	precipitate	NOUN
admet-292	1731	6	exists	exist	VERB
admet-292	1731	7	,	,	PUNCT
admet-292	1731	8	i	i	PRON
admet-292	1731	9	will	will	AUX
admet-292	1731	10	add	add	VERB
admet-292	1731	11	more	more	ADV
admet-292	1731	12	solid	solid	ADJ
admet-292	1731	13	so	so	ADV
admet-292	1731	14	long	long	ADV
admet-292	1731	15	that	that	SCONJ
admet-292	1731	16	some	some	DET
admet-292	1731	17	precipitate	precipitate	NOUN
admet-292	1731	18	will	will	AUX
admet-292	1731	19	appear	appear	VERB
admet-292	1731	20	.	.	PUNCT
admet-292	1732	1	but	but	CCONJ
admet-292	1732	2	if	if	SCONJ
admet-292	1732	3	i	i	PRON
admet-292	1732	4	use	use	VERB
admet-292	1732	5	this	this	DET
admet-292	1732	6	protocol	protocol	NOUN
admet-292	1732	7	,	,	PUNCT
admet-292	1732	8	then	then	ADV
admet-292	1732	9	i	i	PRON
admet-292	1732	10	'm	be	AUX
admet-292	1732	11	not	not	PART
admet-292	1732	12	able	able	ADJ
admet-292	1732	13	to	to	PART
admet-292	1732	14	say	say	VERB
admet-292	1732	15	how	how	SCONJ
admet-292	1732	16	much	much	ADJ
admet-292	1732	17	compound	compound	NOUN
admet-292	1732	18	i	i	PRON
admet-292	1732	19	add	add	VERB
admet-292	1732	20	to	to	ADP
admet-292	1732	21	the	the	DET
admet-292	1732	22	solution	solution	NOUN
admet-292	1732	23	.	.	PUNCT
admet-292	1733	1	is	be	AUX
admet-292	1733	2	it	it	PRON
admet-292	1733	3	better	well	ADJ
admet-292	1733	4	to	to	PART
admet-292	1733	5	perform	perform	VERB
admet-292	1733	6	some	some	DET
admet-292	1733	7	advance	advance	NOUN
admet-292	1733	8	experiments	experiment	NOUN
admet-292	1733	9	before	before	ADP
admet-292	1733	10	final	final	ADJ
admet-292	1733	11	experiment	experiment	NOUN
admet-292	1733	12	to	to	PART
admet-292	1733	13	get	get	VERB
admet-292	1733	14	some	some	DET
admet-292	1733	15	information	information	NOUN
admet-292	1733	16	about	about	ADP
admet-292	1733	17	solubility	solubility	NOUN
admet-292	1733	18	?	?	PUNCT
admet-292	1734	1	another	another	DET
admet-292	1734	2	possibility	possibility	NOUN
admet-292	1734	3	is	be	AUX
admet-292	1734	4	to	to	PART
admet-292	1734	5	use	use	VERB
admet-292	1734	6	dmso	dmso	ADJ
admet-292	1734	7	stock	stock	NOUN
admet-292	1734	8	solution	solution	NOUN
admet-292	1734	9	of	of	ADP
admet-292	1734	10	compound	compound	NOUN
admet-292	1734	11	,	,	PUNCT
admet-292	1734	12	but	but	CCONJ
admet-292	1734	13	that	that	PRON
admet-292	1734	14	creates	create	VERB
admet-292	1734	15	another	another	DET
admet-292	1734	16	problem	problem	NOUN
admet-292	1734	17	.	.	PUNCT
admet-292	1735	1	if	if	SCONJ
admet-292	1735	2	i	i	PRON
admet-292	1735	3	need	need	VERB
admet-292	1735	4	to	to	PART
admet-292	1735	5	add	add	VERB
admet-292	1735	6	too	too	ADV
admet-292	1735	7	much	much	ADJ
admet-292	1735	8	dmso	dmso	ADJ
admet-292	1735	9	solution	solution	NOUN
admet-292	1735	10	,	,	PUNCT
admet-292	1735	11	then	then	ADV
admet-292	1735	12	dmso	dmso	ADJ
admet-292	1735	13	concentration	concentration	NOUN
admet-292	1735	14	in	in	ADP
admet-292	1735	15	solution	solution	NOUN
admet-292	1735	16	will	will	AUX
admet-292	1735	17	go	go	VERB
admet-292	1735	18	very	very	ADV
admet-292	1735	19	high	high	ADJ
admet-292	1735	20	and	and	CCONJ
admet-292	1735	21	then	then	ADV
admet-292	1735	22	may	may	AUX
admet-292	1735	23	influence	influence	VERB
admet-292	1735	24	solubility	solubility	NOUN
admet-292	1735	25	.	.	PUNCT
admet-292	1736	1	so	so	ADV
admet-292	1736	2	now	now	ADV
admet-292	1736	3	i	i	PRON
admet-292	1736	4	'm	be	AUX
admet-292	1736	5	a	a	DET
admet-292	1736	6	little	little	ADJ
admet-292	1736	7	confused	confused	ADJ
admet-292	1737	1	and	and	CCONJ
admet-292	1737	2	i	i	PRON
admet-292	1737	3	ca	can	AUX
admet-292	1737	4	n't	not	PART
admet-292	1737	5	decide	decide	VERB
admet-292	1737	6	which	which	PRON
admet-292	1737	7	is	be	AUX
admet-292	1737	8	the	the	DET
admet-292	1737	9	better	well	ADJ
admet-292	1737	10	option	option	NOUN
admet-292	1737	11	.	.	PUNCT
admet-292	1738	1	which	which	DET
admet-292	1738	2	method	method	NOUN
admet-292	1738	3	do	do	AUX
admet-292	1738	4	you	you	PRON
admet-292	1738	5	recommend	recommend	VERB
admet-292	1738	6	?	?	PUNCT
admet-292	1739	1	alex	alex	PROPN
admet-292	1739	2	avdeef	avdeef	PROPN
admet-292	1739	3	et	et	PROPN
admet-292	1739	4	al	al	PROPN
admet-292	1739	5	.	.	PROPN
admet-292	1739	6	admet	admet	PROPN
admet-292	1739	7	&	&	CCONJ
admet-292	1739	8	dmpk	dmpk	PROPN
admet-292	1739	9	4(2	4(2	NUM
admet-292	1739	10	)	)	PUNCT
admet-292	1739	11	(	(	PUNCT
admet-292	1739	12	2016	2016	NUM
admet-292	1739	13	)	)	PUNCT
admet-292	1739	14	117	117	NUM
admet-292	1739	15	-	-	SYM
admet-292	1739	16	178	178	NUM
admet-292	1739	17	176	176	NUM
admet-292	1739	18	a2	a2	NOUN
admet-292	1739	19	:	:	PUNCT
admet-292	1739	20	it	it	PRON
admet-292	1739	21	is	be	AUX
admet-292	1739	22	advisable	advisable	ADJ
admet-292	1739	23	to	to	PART
admet-292	1739	24	work	work	VERB
admet-292	1739	25	out	out	ADP
admet-292	1739	26	a	a	DET
admet-292	1739	27	general	general	ADJ
admet-292	1739	28	protocol	protocol	NOUN
admet-292	1739	29	at	at	ADP
admet-292	1739	30	the	the	DET
admet-292	1739	31	start	start	NOUN
admet-292	1739	32	,	,	PUNCT
admet-292	1739	33	which	which	PRON
admet-292	1739	34	can	can	AUX
admet-292	1739	35	be	be	AUX
admet-292	1739	36	suitable	suitable	ADJ
admet-292	1739	37	for	for	ADP
admet-292	1739	38	the	the	DET
admet-292	1739	39	majority	majority	NOUN
admet-292	1739	40	of	of	ADP
admet-292	1739	41	compounds	compound	NOUN
admet-292	1739	42	(	(	PUNCT
admet-292	1739	43	given	give	VERB
admet-292	1739	44	non	non	ADJ
admet-292	1739	45	-	-	ADJ
admet-292	1739	46	problematic	problematic	ADJ
admet-292	1739	47	molecules	molecule	NOUN
admet-292	1739	48	)	)	PUNCT
admet-292	1739	49	.	.	PUNCT
admet-292	1740	1	someone	someone	PRON
admet-292	1740	2	new	new	ADJ
admet-292	1740	3	to	to	ADP
admet-292	1740	4	solubility	solubility	NOUN
admet-292	1740	5	measurement	measurement	NOUN
admet-292	1740	6	needs	need	VERB
admet-292	1740	7	to	to	PART
admet-292	1740	8	practice	practice	VERB
admet-292	1740	9	with	with	ADP
admet-292	1740	10	easy	easy	ADJ
admet-292	1740	11	compounds	compound	NOUN
admet-292	1740	12	.	.	PUNCT
admet-292	1741	1	a	a	DET
admet-292	1741	2	preliminary	preliminary	ADJ
admet-292	1741	3	experiment	experiment	NOUN
admet-292	1741	4	is	be	AUX
admet-292	1741	5	useful	useful	ADJ
admet-292	1741	6	:	:	PUNCT
admet-292	1741	7	try	try	VERB
admet-292	1741	8	to	to	PART
admet-292	1741	9	dissolve	dissolve	VERB
admet-292	1741	10	10	10	NUM
admet-292	1741	11	mg	mg	NOUN
admet-292	1741	12	solid	solid	ADJ
admet-292	1741	13	in	in	ADP
admet-292	1741	14	1	1	NUM
admet-292	1741	15	ml	ml	NOUN
admet-292	1741	16	solvent	solvent	NOUN
admet-292	1741	17	;	;	PUNCT
admet-292	1741	18	if	if	SCONJ
admet-292	1741	19	the	the	DET
admet-292	1741	20	solid	solid	NOUN
admet-292	1741	21	is	be	AUX
admet-292	1741	22	not	not	PART
admet-292	1741	23	fully	fully	ADV
admet-292	1741	24	dissolved	dissolve	VERB
admet-292	1741	25	,	,	PUNCT
admet-292	1741	26	add	add	VERB
admet-292	1741	27	an	an	DET
admet-292	1741	28	additional	additional	ADJ
admet-292	1741	29	9	9	NUM
admet-292	1741	30	ml	ml	NOUN
admet-292	1741	31	of	of	ADP
admet-292	1741	32	solvent	solvent	NOUN
admet-292	1741	33	(	(	PUNCT
admet-292	1741	34	1	1	NUM
admet-292	1741	35	mg	mg	NUM
admet-292	1741	36	/	/	SYM
admet-292	1741	37	ml	ml	NOUN
admet-292	1741	38	)	)	PUNCT
admet-292	1741	39	.	.	PUNCT
admet-292	1742	1	i	i	PRON
admet-292	1742	2	would	would	AUX
admet-292	1742	3	avoid	avoid	VERB
admet-292	1742	4	adding	add	VERB
admet-292	1742	5	meoh	meoh	PROPN
admet-292	1742	6	or	or	CCONJ
admet-292	1742	7	dmso	dmso	NOUN
admet-292	1742	8	to	to	ADP
admet-292	1742	9	the	the	DET
admet-292	1742	10	crystals	crystal	NOUN
admet-292	1742	11	.	.	PUNCT
admet-292	1743	1	rather	rather	ADV
admet-292	1743	2	i	i	PRON
admet-292	1743	3	suggest	suggest	VERB
admet-292	1743	4	to	to	PART
admet-292	1743	5	increase	increase	VERB
admet-292	1743	6	the	the	DET
admet-292	1743	7	stirring	stirring	ADJ
admet-292	1743	8	time	time	NOUN
admet-292	1743	9	and	and	CCONJ
admet-292	1743	10	to	to	PART
admet-292	1743	11	change	change	VERB
admet-292	1743	12	the	the	DET
admet-292	1743	13	speed	speed	NOUN
admet-292	1743	14	from	from	ADP
admet-292	1743	15	low	low	ADJ
admet-292	1743	16	to	to	PART
admet-292	1743	17	fast	fast	VERB
admet-292	1743	18	and	and	CCONJ
admet-292	1743	19	back	back	ADV
admet-292	1743	20	many	many	ADJ
admet-292	1743	21	times	time	NOUN
admet-292	1743	22	.	.	PUNCT
admet-292	1744	1	after	after	ADP
admet-292	1744	2	the	the	DET
admet-292	1744	3	preliminary	preliminary	ADJ
admet-292	1744	4	work	work	NOUN
admet-292	1744	5	,	,	PUNCT
admet-292	1744	6	the	the	DET
admet-292	1744	7	frequent	frequent	ADJ
admet-292	1744	8	difficulties	difficulty	NOUN
admet-292	1744	9	in	in	ADP
admet-292	1744	10	the	the	DET
admet-292	1744	11	case	case	NOUN
admet-292	1744	12	of	of	ADP
admet-292	1744	13	poorly	poorly	ADV
admet-292	1744	14	soluble	soluble	ADJ
admet-292	1744	15	compounds	compound	NOUN
admet-292	1744	16	(	(	PUNCT
admet-292	1744	17	problematic	problematic	ADJ
admet-292	1744	18	molecules	molecule	NOUN
admet-292	1744	19	)	)	PUNCT
admet-292	1744	20	can	can	AUX
admet-292	1744	21	be	be	AUX
admet-292	1744	22	considered	consider	VERB
admet-292	1744	23	.	.	PUNCT
admet-292	1745	1	procedures	procedure	NOUN
admet-292	1745	2	in	in	ADP
admet-292	1745	3	the	the	DET
admet-292	1745	4	refined	refined	ADJ
admet-292	1745	5	ssf	ssf	NOUN
admet-292	1745	6	protocol	protocol	PROPN
admet-292	1745	7	(	(	PUNCT
admet-292	1745	8	baka	baka	PROPN
admet-292	1745	9	et	et	PROPN
admet-292	1745	10	al	al	PROPN
admet-292	1745	11	.	.	PROPN
admet-292	1746	1	jpba	jpba	PROPN
admet-292	1746	2	,	,	PUNCT
admet-292	1746	3	2008	2008	NUM
admet-292	1746	4	)	)	PUNCT
admet-292	1746	5	may	may	AUX
admet-292	1746	6	be	be	AUX
admet-292	1746	7	recommended	recommend	VERB
admet-292	1746	8	:	:	PUNCT
admet-292	1746	9	two	two	NUM
admet-292	1746	10	-	-	ADJ
admet-292	1746	11	fold	fold	VERB
admet-292	1746	12	excess	excess	NOUN
admet-292	1746	13	of	of	ADP
admet-292	1746	14	solid	solid	ADJ
admet-292	1746	15	control	control	NOUN
admet-292	1746	16	the	the	DET
admet-292	1746	17	ph	ph	NOUN
admet-292	1746	18	after	after	ADP
admet-292	1746	19	1	1	NUM
admet-292	1746	20	h	h	NOUN
admet-292	1746	21	stirring	stirring	NOUN
admet-292	1746	22	,	,	PUNCT
admet-292	1746	23	re	re	VERB
admet-292	1746	24	-	-	VERB
admet-292	1746	25	adjust	adjust	VERB
admet-292	1746	26	if	if	SCONJ
admet-292	1746	27	necessary	necessary	ADJ
admet-292	1746	28	incubation	incubation	NOUN
admet-292	1746	29	:	:	PUNCT
admet-292	1746	30	6	6	NUM
admet-292	1746	31	h	h	NOUN
admet-292	1746	32	stirring	stir	VERB
admet-292	1746	33	+	+	CCONJ
admet-292	1746	34	18	18	NUM
admet-292	1746	35	h	h	NOUN
admet-292	1746	36	sedimentation	sedimentation	NOUN
admet-292	1746	37	minimum	minimum	NOUN
admet-292	1746	38	of	of	ADP
admet-292	1746	39	3	3	NUM
admet-292	1746	40	replicates	replicate	NOUN
admet-292	1746	41	a1	a1	NOUN
admet-292	1746	42	:	:	PUNCT
admet-292	1746	43	in	in	ADP
admet-292	1746	44	principle	principle	NOUN
admet-292	1746	45	,	,	PUNCT
admet-292	1746	46	pdisol	pdisol	NOUN
admet-292	1746	47	-	-	PUNCT
admet-292	1746	48	x	x	NOUN
admet-292	1746	49	should	should	AUX
admet-292	1746	50	be	be	AUX
admet-292	1746	51	able	able	ADJ
admet-292	1746	52	to	to	PART
admet-292	1746	53	suggest	suggest	VERB
admet-292	1746	54	how	how	SCONJ
admet-292	1746	55	much	much	ADJ
admet-292	1746	56	solid	solid	ADJ
admet-292	1746	57	to	to	PART
admet-292	1746	58	add	add	VERB
admet-292	1746	59	,	,	PUNCT
admet-292	1746	60	since	since	SCONJ
admet-292	1746	61	solubility	solubility	NOUN
admet-292	1746	62	is	be	AUX
admet-292	1746	63	first	first	ADV
admet-292	1746	64	predicted	predict	VERB
admet-292	1746	65	in	in	ADP
admet-292	1746	66	pdisol	pdisol	ADJ
admet-292	1746	67	-	-	PUNCT
admet-292	1746	68	x	x	NOUN
admet-292	1746	69	and	and	CCONJ
admet-292	1746	70	information	information	NOUN
admet-292	1746	71	about	about	ADP
admet-292	1746	72	buffers	buffer	NOUN
admet-292	1746	73	exists	exist	VERB
admet-292	1746	74	.	.	PUNCT
admet-292	1747	1	most	most	ADJ
admet-292	1747	2	people	people	NOUN
admet-292	1747	3	will	will	AUX
admet-292	1747	4	not	not	PART
admet-292	1747	5	use	use	VERB
admet-292	1747	6	pdisol	pdisol	ADJ
admet-292	1747	7	-	-	PUNCT
admet-292	1747	8	x	x	NOUN
admet-292	1747	9	,	,	PUNCT
admet-292	1747	10	so	so	ADV
admet-292	1747	11	the	the	DET
admet-292	1747	12	guessing	guess	VERB
admet-292	1747	13	game	game	NOUN
admet-292	1747	14	will	will	AUX
admet-292	1747	15	continue	continue	VERB
admet-292	1747	16	.	.	PUNCT
admet-292	1748	1	my	my	PRON
admet-292	1748	2	advice	advice	NOUN
admet-292	1748	3	is	be	AUX
admet-292	1748	4	to	to	PART
admet-292	1748	5	keep	keep	VERB
admet-292	1748	6	track	track	NOUN
admet-292	1748	7	of	of	ADP
admet-292	1748	8	how	how	SCONJ
admet-292	1748	9	much	much	ADJ
admet-292	1748	10	solid	solid	ADJ
admet-292	1748	11	was	be	AUX
admet-292	1748	12	added	add	VERB
admet-292	1748	13	by	by	ADP
admet-292	1748	14	weighting	weight	VERB
admet-292	1748	15	the	the	DET
admet-292	1748	16	vile	vile	NOUN
admet-292	1748	17	before	before	ADP
admet-292	1748	18	and	and	CCONJ
admet-292	1748	19	after	after	ADP
admet-292	1748	20	each	each	DET
admet-292	1748	21	addition	addition	NOUN
admet-292	1748	22	of	of	ADP
admet-292	1748	23	solid	solid	ADJ
admet-292	1748	24	.	.	PUNCT
admet-292	1749	1	this	this	PRON
admet-292	1749	2	is	be	AUX
admet-292	1749	3	more	more	ADV
admet-292	1749	4	important	important	ADJ
admet-292	1749	5	in	in	ADP
admet-292	1749	6	the	the	DET
admet-292	1749	7	salt	salt	NOUN
admet-292	1749	8	region	region	NOUN
admet-292	1749	9	,	,	PUNCT
admet-292	1749	10	since	since	SCONJ
admet-292	1749	11	that	that	PRON
admet-292	1749	12	is	be	AUX
admet-292	1749	13	where	where	SCONJ
admet-292	1749	14	supersaturation	supersaturation	NOUN
admet-292	1749	15	is	be	AUX
admet-292	1749	16	most	most	ADV
admet-292	1749	17	likely	likely	ADJ
admet-292	1749	18	to	to	PART
admet-292	1749	19	occur	occur	VERB
admet-292	1749	20	,	,	PUNCT
admet-292	1749	21	or	or	CCONJ
admet-292	1749	22	where	where	SCONJ
admet-292	1749	23	micelles	micelle	NOUN
admet-292	1749	24	and	and	CCONJ
admet-292	1749	25	salt	salt	NOUN
admet-292	1749	26	compete	compete	VERB
admet-292	1749	27	with	with	ADP
admet-292	1749	28	one	one	NUM
admet-292	1749	29	another	another	DET
admet-292	1749	30	for	for	ADP
admet-292	1749	31	the	the	DET
admet-292	1749	32	compound	compound	NOUN
admet-292	1749	33	.	.	PUNCT
admet-292	1750	1	please	please	INTJ
admet-292	1750	2	keep	keep	VERB
admet-292	1750	3	track	track	NOUN
admet-292	1750	4	of	of	ADP
admet-292	1750	5	how	how	SCONJ
admet-292	1750	6	much	much	ADJ
admet-292	1750	7	compound	compound	NOUN
admet-292	1750	8	is	be	AUX
admet-292	1750	9	added	add	VERB
admet-292	1750	10	.	.	PUNCT
admet-292	1751	1	i	i	PRON
admet-292	1751	2	do	do	AUX
admet-292	1751	3	n’t	not	PART
admet-292	1751	4	recommend	recommend	VERB
admet-292	1751	5	using	use	VERB
admet-292	1751	6	dmso	dmso	NOUN
admet-292	1751	7	stock	stock	NOUN
admet-292	1751	8	.	.	PUNCT
admet-292	1752	1	(	(	PUNCT
admet-292	1752	2	cf	cf	NOUN
admet-292	1752	3	.	.	PROPN
admet-292	1752	4	,	,	PUNCT
admet-292	1752	5	chen	chen	PROPN
admet-292	1752	6	et	et	PROPN
admet-292	1752	7	al	al	PROPN
admet-292	1752	8	.	.	PROPN
admet-292	1752	9	,	,	PUNCT
admet-292	1752	10	combi	combi	PROPN
admet-292	1752	11	.	.	PUNCT
admet-292	1753	1	chem	chem	PROPN
admet-292	1753	2	.	.	PUNCT
admet-292	1754	1	hts	hts	PROPN
admet-292	1754	2	2002	2002	NUM
admet-292	1754	3	,	,	PUNCT
admet-292	1754	4	5	5	NUM
admet-292	1754	5	,	,	PUNCT
admet-292	1754	6	575	575	NUM
admet-292	1754	7	-	-	SYM
admet-292	1754	8	581	581	NUM
admet-292	1754	9	)	)	PUNCT
admet-292	1754	10	.	.	PUNCT
admet-292	1755	1	if	if	SCONJ
admet-292	1755	2	solubility	solubility	NOUN
admet-292	1755	3	is	be	AUX
admet-292	1755	4	a	a	DET
admet-292	1755	5	problem	problem	NOUN
admet-292	1755	6	and	and	CCONJ
admet-292	1755	7	if	if	SCONJ
admet-292	1755	8	you	you	PRON
admet-292	1755	9	need	need	VERB
admet-292	1755	10	to	to	PART
admet-292	1755	11	prepare	prepare	VERB
admet-292	1755	12	a	a	DET
admet-292	1755	13	stock	stock	NOUN
admet-292	1755	14	solution	solution	NOUN
admet-292	1755	15	,	,	PUNCT
admet-292	1755	16	use	use	VERB
admet-292	1755	17	methanol	methanol	NOUN
admet-292	1755	18	(	(	PUNCT
admet-292	1755	19	or	or	CCONJ
admet-292	1755	20	any	any	DET
admet-292	1755	21	other	other	ADJ
admet-292	1755	22	suitable	suitable	ADJ
admet-292	1755	23	volatile	volatile	ADJ
admet-292	1755	24	solvent	solvent	NOUN
admet-292	1755	25	)	)	PUNCT
admet-292	1755	26	.	.	PUNCT
admet-292	1756	1	when	when	SCONJ
admet-292	1756	2	the	the	DET
admet-292	1756	3	solution	solution	NOUN
admet-292	1756	4	is	be	AUX
admet-292	1756	5	added	add	VERB
admet-292	1756	6	to	to	ADP
admet-292	1756	7	the	the	DET
admet-292	1756	8	vial	vial	ADJ
admet-292	1756	9	(	(	PUNCT
admet-292	1756	10	before	before	SCONJ
admet-292	1756	11	buffer	buffer	NOUN
admet-292	1756	12	is	be	AUX
admet-292	1756	13	added	add	VERB
admet-292	1756	14	)	)	PUNCT
admet-292	1756	15	,	,	PUNCT
admet-292	1756	16	you	you	PRON
admet-292	1756	17	can	can	AUX
admet-292	1756	18	let	let	VERB
admet-292	1756	19	the	the	DET
admet-292	1756	20	methanol	methanol	NOUN
admet-292	1756	21	completely	completely	ADV
admet-292	1756	22	evaporate	evaporate	VERB
admet-292	1756	23	,	,	PUNCT
admet-292	1756	24	before	before	ADP
admet-292	1756	25	adding	add	VERB
admet-292	1756	26	buffer	buffer	NOUN
admet-292	1756	27	.	.	PUNCT
admet-292	1757	1	but	but	CCONJ
admet-292	1757	2	stay	stay	VERB
admet-292	1757	3	away	away	ADV
admet-292	1757	4	from	from	ADP
admet-292	1757	5	dmso	dmso	NOUN
admet-292	1757	6	,	,	PUNCT
admet-292	1757	7	if	if	SCONJ
admet-292	1757	8	you	you	PRON
admet-292	1757	9	are	be	AUX
admet-292	1757	10	interested	interested	ADJ
admet-292	1757	11	in	in	ADP
admet-292	1757	12	measuring	measure	VERB
admet-292	1757	13	true	true	ADJ
admet-292	1757	14	aqueous	aqueous	ADJ
admet-292	1757	15	solubility	solubility	NOUN
admet-292	1757	16	.	.	PUNCT
admet-292	1758	1	q	q	X
admet-292	1758	2	:	:	PUNCT
admet-292	1758	3	other	other	ADJ
admet-292	1758	4	question	question	NOUN
admet-292	1758	5	is	be	AUX
admet-292	1758	6	about	about	ADP
admet-292	1758	7	filtration	filtration	NOUN
admet-292	1758	8	.	.	PUNCT
admet-292	1759	1	if	if	SCONJ
admet-292	1759	2	i	i	PRON
admet-292	1759	3	remember	remember	VERB
admet-292	1759	4	correctly	correctly	ADV
admet-292	1759	5	,	,	PUNCT
admet-292	1759	6	the	the	DET
admet-292	1759	7	best	good	ADJ
admet-292	1759	8	filter	filter	NOUN
admet-292	1759	9	option	option	NOUN
admet-292	1759	10	is	be	AUX
admet-292	1759	11	0.2	0.2	NUM
admet-292	1759	12	or	or	CCONJ
admet-292	1759	13	0.45	0.45	NUM
admet-292	1759	14	μm	μm	NUM
admet-292	1759	15	hydrophilic	hydrophilic	ADJ
admet-292	1759	16	pvdf	pvdf	PROPN
admet-292	1759	17	filter	filter	NOUN
admet-292	1759	18	.	.	PUNCT
admet-292	1760	1	is	be	AUX
admet-292	1760	2	it	it	PRON
admet-292	1760	3	correct	correct	ADJ
admet-292	1760	4	?	?	PUNCT
admet-292	1761	1	is	be	AUX
admet-292	1761	2	it	it	PRON
admet-292	1761	3	correct	correct	ADJ
admet-292	1761	4	to	to	PART
admet-292	1761	5	use	use	VERB
admet-292	1761	6	filter	filter	NOUN
admet-292	1761	7	plate	plate	NOUN
admet-292	1761	8	with	with	ADP
admet-292	1761	9	vacuum	vacuum	PROPN
admet-292	1761	10	manifold	manifold	NOUN
admet-292	1761	11	for	for	ADP
admet-292	1761	12	the	the	DET
admet-292	1761	13	separation	separation	NOUN
admet-292	1761	14	or	or	CCONJ
admet-292	1761	15	better	well	ADJ
admet-292	1761	16	is	be	AUX
admet-292	1761	17	use	use	VERB
admet-292	1761	18	individual	individual	ADJ
admet-292	1761	19	filters	filter	NOUN
admet-292	1761	20	?	?	PUNCT
admet-292	1762	1	i	i	PRON
admet-292	1762	2	plan	plan	VERB
admet-292	1762	3	to	to	PART
admet-292	1762	4	perform	perform	VERB
admet-292	1762	5	experiments	experiment	NOUN
admet-292	1762	6	in	in	ADP
admet-292	1762	7	2	2	NUM
admet-292	1762	8	ml	ml	NOUN
admet-292	1762	9	vials	vial	NOUN
admet-292	1762	10	and	and	CCONJ
admet-292	1762	11	then	then	ADV
admet-292	1762	12	pipetting	pipette	VERB
admet-292	1762	13	the	the	DET
admet-292	1762	14	solution	solution	NOUN
admet-292	1762	15	to	to	ADP
admet-292	1762	16	the	the	DET
admet-292	1762	17	filter	filter	NOUN
admet-292	1762	18	plate	plate	NOUN
admet-292	1762	19	.	.	PUNCT
admet-292	1763	1	is	be	AUX
admet-292	1763	2	it	it	PRON
admet-292	1763	3	good	good	ADJ
admet-292	1763	4	plan	plan	NOUN
admet-292	1763	5	?	?	PUNCT
admet-292	1764	1	a1	a1	NOUN
admet-292	1764	2	:	:	PUNCT
admet-292	1764	3	see	see	VERB
admet-292	1764	4	kristina	kristina	PROPN
admet-292	1764	5	’s	’s	PART
admet-292	1764	6	poster	poster	NOUN
admet-292	1764	7	about	about	ADP
admet-292	1764	8	filters	filter	NOUN
admet-292	1764	9	.	.	PUNCT
admet-292	1765	1	my	my	PRON
admet-292	1765	2	own	own	ADJ
admet-292	1765	3	preference	preference	NOUN
admet-292	1765	4	is	be	AUX
admet-292	1765	5	to	to	PART
admet-292	1765	6	use	use	VERB
admet-292	1765	7	disposable	disposable	ADJ
admet-292	1765	8	filter	filter	NOUN
admet-292	1765	9	tips	tip	NOUN
admet-292	1765	10	that	that	PRON
admet-292	1765	11	attach	attach	VERB
admet-292	1765	12	to	to	ADP
admet-292	1765	13	syringes	syrinx	NOUN
admet-292	1765	14	,	,	PUNCT
admet-292	1765	15	0.2/0.45	0.2/0.45	NOUN
admet-292	1765	16	μm	μm	NUM
admet-292	1765	17	-	-	PUNCT
admet-292	1765	18	pore	pore	ADJ
admet-292	1765	19	hydrophilic	hydrophilic	PROPN
admet-292	1765	20	pvdf	pvdf	PROPN
admet-292	1765	21	.	.	PUNCT
admet-292	1766	1	draw	draw	VERB
admet-292	1766	2	in	in	ADP
admet-292	1766	3	the	the	DET
admet-292	1766	4	suspension	suspension	NOUN
admet-292	1766	5	slowly	slowly	ADV
admet-292	1766	6	,	,	PUNCT
admet-292	1766	7	discard	discard	VERB
admet-292	1766	8	the	the	DET
admet-292	1766	9	first	first	ADJ
admet-292	1766	10	25	25	NUM
admet-292	1766	11	-	-	SYM
admet-292	1766	12	50	50	NUM
admet-292	1766	13	%	%	NOUN
admet-292	1766	14	,	,	PUNCT
admet-292	1766	15	and	and	CCONJ
admet-292	1766	16	use	use	VERB
admet-292	1766	17	the	the	DET
admet-292	1766	18	remainder	remainder	NOUN
admet-292	1766	19	for	for	ADP
admet-292	1766	20	the	the	DET
admet-292	1766	21	assay	assay	NOUN
admet-292	1766	22	.	.	PUNCT
admet-292	1767	1	there	there	PRON
admet-292	1767	2	is	be	VERB
admet-292	1767	3	a	a	DET
admet-292	1767	4	lot	lot	NOUN
admet-292	1767	5	more	more	ADJ
admet-292	1767	6	to	to	PART
admet-292	1767	7	be	be	AUX
admet-292	1767	8	said	say	VERB
admet-292	1767	9	about	about	ADP
admet-292	1767	10	filtration	filtration	NOUN
admet-292	1767	11	.	.	PUNCT
admet-292	1768	1	a2	a2	PROPN
admet-292	1768	2	:	:	PUNCT
admet-292	1769	1	yes	yes	INTJ
admet-292	1769	2	,	,	PUNCT
admet-292	1769	3	it	it	PRON
admet-292	1769	4	is	be	AUX
admet-292	1769	5	better	well	ADJ
admet-292	1769	6	to	to	PART
admet-292	1769	7	avoid	avoid	VERB
admet-292	1769	8	filtration	filtration	NOUN
admet-292	1769	9	.	.	PUNCT
admet-292	1770	1	if	if	SCONJ
admet-292	1770	2	this	this	PRON
admet-292	1770	3	is	be	AUX
admet-292	1770	4	not	not	PART
admet-292	1770	5	possible	possible	ADJ
admet-292	1770	6	,	,	PUNCT
admet-292	1770	7	then	then	ADV
admet-292	1770	8	select	select	VERB
admet-292	1770	9	the	the	DET
admet-292	1770	10	right	right	ADJ
admet-292	1770	11	filter	filter	NOUN
admet-292	1770	12	type	type	NOUN
admet-292	1770	13	and	and	CCONJ
admet-292	1770	14	use	use	VERB
admet-292	1770	15	0.2	0.2	NUM
admet-292	1770	16	or	or	CCONJ
admet-292	1770	17	0.45	0.45	NUM
admet-292	1770	18	μm	μm	NOUN
admet-292	1770	19	pore	pore	ADJ
admet-292	1770	20	.	.	PUNCT
admet-292	1771	1	discarding	discard	VERB
admet-292	1771	2	the	the	DET
admet-292	1771	3	first	first	ADJ
admet-292	1771	4	portion	portion	NOUN
admet-292	1771	5	of	of	ADP
admet-292	1771	6	filtrate	filtrate	NOUN
admet-292	1771	7	reduces	reduce	VERB
admet-292	1771	8	the	the	DET
admet-292	1771	9	error	error	NOUN
admet-292	1771	10	which	which	PRON
admet-292	1771	11	can	can	AUX
admet-292	1771	12	be	be	AUX
admet-292	1771	13	caused	cause	VERB
admet-292	1771	14	by	by	ADP
admet-292	1771	15	the	the	DET
admet-292	1771	16	adsorption	adsorption	NOUN
admet-292	1771	17	to	to	ADP
admet-292	1771	18	the	the	DET
admet-292	1771	19	filter	filter	NOUN
admet-292	1771	20	.	.	PUNCT
admet-292	1772	1	never	never	ADV
admet-292	1772	2	filter	filter	VERB
admet-292	1772	3	directly	directly	ADV
admet-292	1772	4	after	after	ADP
admet-292	1772	5	agitation	agitation	NOUN
admet-292	1772	6	,	,	PUNCT
admet-292	1772	7	keep	keep	VERB
admet-292	1772	8	the	the	DET
admet-292	1772	9	sedimentation	sedimentation	NOUN
admet-292	1772	10	/	/	SYM
admet-292	1772	11	resting	rest	VERB
admet-292	1772	12	time	time	NOUN
admet-292	1772	13	allowing	allow	VERB
admet-292	1772	14	the	the	DET
admet-292	1772	15	system	system	NOUN
admet-292	1772	16	to	to	PART
admet-292	1772	17	reach	reach	VERB
admet-292	1772	18	the	the	DET
admet-292	1772	19	equilibrium	equilibrium	NOUN
admet-292	1772	20	.	.	PUNCT
admet-292	1773	1	for	for	ADP
admet-292	1773	2	very	very	ADV
admet-292	1773	3	stable	stable	ADJ
admet-292	1773	4	colloidal	colloidal	NOUN
admet-292	1773	5	system	system	NOUN
admet-292	1773	6	ultracentrifugation	ultracentrifugation	NOUN
admet-292	1773	7	can	can	AUX
admet-292	1773	8	be	be	AUX
admet-292	1773	9	a	a	DET
admet-292	1773	10	solution	solution	NOUN
admet-292	1773	11	for	for	ADP
admet-292	1773	12	phase	phase	NOUN
admet-292	1773	13	separation	separation	NOUN
admet-292	1773	14	.	.	PUNCT
admet-292	1774	1	q	q	X
admet-292	1774	2	:	:	PUNCT
admet-292	1774	3	next	next	ADJ
admet-292	1774	4	question	question	NOUN
admet-292	1774	5	is	be	AUX
admet-292	1774	6	about	about	ADP
admet-292	1774	7	buffer	buffer	NOUN
admet-292	1774	8	.	.	PUNCT
admet-292	1775	1	is	be	AUX
admet-292	1775	2	it	it	PRON
admet-292	1775	3	better	well	ADJ
admet-292	1775	4	to	to	PART
admet-292	1775	5	use	use	VERB
admet-292	1775	6	universal	universal	ADJ
admet-292	1775	7	buffer	buffer	NOUN
admet-292	1775	8	(	(	PUNCT
admet-292	1775	9	same	same	ADJ
admet-292	1775	10	compounds	compound	NOUN
admet-292	1775	11	as	as	SCONJ
admet-292	1775	12	your	your	PRON
admet-292	1775	13	slides	slide	NOUN
admet-292	1775	14	:	:	PUNCT
admet-292	1775	15	glycolic	glycolic	NOUN
admet-292	1775	16	acid	acid	NOUN
admet-292	1775	17	,	,	PUNCT
admet-292	1775	18	acetic	acetic	ADJ
admet-292	1775	19	acid	acid	NOUN
admet-292	1775	20	,	,	PUNCT
admet-292	1775	21	mes	me	NOUN
admet-292	1775	22	,	,	PUNCT
admet-292	1775	23	hepes	hepe	NOUN
admet-292	1775	24	and	and	CCONJ
admet-292	1775	25	taurine	taurine	NOUN
admet-292	1775	26	)	)	PUNCT
admet-292	1775	27	or	or	CCONJ
admet-292	1775	28	britton	britton	PROPN
admet-292	1775	29	-	-	PUNCT
admet-292	1775	30	robinson	robinson	PROPN
admet-292	1775	31	buffer	buffer	NOUN
admet-292	1775	32	for	for	ADP
admet-292	1775	33	the	the	DET
admet-292	1775	34	solubility	solubility	NOUN
admet-292	1775	35	assay	assay	VERB
admet-292	1775	36	?	?	PUNCT
admet-292	1776	1	universal	universal	ADJ
admet-292	1776	2	buffer	buffer	NOUN
admet-292	1776	3	should	should	AUX
admet-292	1776	4	be	be	AUX
admet-292	1776	5	better	well	ADJ
admet-292	1776	6	,	,	PUNCT
admet-292	1776	7	but	but	CCONJ
admet-292	1776	8	otherwise	otherwise	ADV
admet-292	1776	9	britton	britton	PROPN
admet-292	1776	10	-	-	PUNCT
admet-292	1776	11	robinson	robinson	PROPN
admet-292	1776	12	buffer	buffer	NOUN
admet-292	1776	13	[	[	X
admet-292	1776	14	comprises	comprise	VERB
admet-292	1776	15	fewer	few	ADJ
admet-292	1776	16	components	component	NOUN
admet-292	1776	17	]	]	PUNCT
admet-292	1776	18	.	.	PUNCT
admet-292	1777	1	which	which	DET
admet-292	1777	2	buffer	buffer	VERB
admet-292	1777	3	do	do	AUX
admet-292	1777	4	you	you	PRON
admet-292	1777	5	recommend	recommend	VERB
admet-292	1777	6	?	?	PUNCT
admet-292	1778	1	a2	a2	PROPN
admet-292	1778	2	:	:	PUNCT
admet-292	1779	1	i	i	PRON
admet-292	1779	2	think	think	VERB
admet-292	1779	3	the	the	DET
admet-292	1779	4	use	use	NOUN
admet-292	1779	5	of	of	ADP
admet-292	1779	6	the	the	DET
admet-292	1779	7	same	same	ADJ
admet-292	1779	8	buffer	buffer	NOUN
admet-292	1779	9	in	in	ADP
admet-292	1779	10	wide	wide	ADJ
admet-292	1779	11	ph	ph	ADJ
admet-292	1779	12	range	range	NOUN
admet-292	1779	13	(	(	PUNCT
admet-292	1779	14	like	like	ADP
admet-292	1779	15	britton	britton	PROPN
admet-292	1779	16	-	-	PUNCT
admet-292	1779	17	robinson	robinson	PROPN
admet-292	1779	18	)	)	PUNCT
admet-292	1779	19	is	be	AUX
admet-292	1779	20	an	an	DET
admet-292	1779	21	advantage	advantage	NOUN
admet-292	1779	22	,	,	PUNCT
admet-292	1779	23	since	since	SCONJ
admet-292	1779	24	all	all	DET
admet-292	1779	25	the	the	DET
admet-292	1779	26	possible	possible	ADJ
admet-292	1779	27	effects	effect	NOUN
admet-292	1779	28	of	of	ADP
admet-292	1779	29	the	the	DET
admet-292	1779	30	buffer	buffer	NOUN
admet-292	1779	31	components	component	NOUN
admet-292	1779	32	should	should	AUX
admet-292	1779	33	be	be	AUX
admet-292	1779	34	the	the	DET
admet-292	1779	35	same	same	ADJ
admet-292	1779	36	.	.	PUNCT
admet-292	1780	1	this	this	DET
admet-292	1780	2	acetate	acetate	NOUN
admet-292	1780	3	-	-	PUNCT
admet-292	1780	4	phosphate	phosphate	NOUN
admet-292	1780	5	-	-	PUNCT
admet-292	1780	6	borate	borate	NOUN
admet-292	1780	7	buffer	buffer	NOUN
admet-292	1780	8	provides	provide	VERB
admet-292	1780	9	enough	enough	ADJ
admet-292	1780	10	buffer	buffer	NOUN
admet-292	1780	11	capacity	capacity	NOUN
admet-292	1780	12	and	and	CCONJ
admet-292	1780	13	no	no	DET
admet-292	1780	14	interactions	interaction	NOUN
admet-292	1780	15	have	have	AUX
admet-292	1780	16	been	be	AUX
admet-292	1780	17	experienced	experience	VERB
admet-292	1780	18	by	by	ADP
admet-292	1780	19	us	we	PRON
admet-292	1780	20	.	.	PUNCT
admet-292	1781	1	a1	a1	PROPN
admet-292	1781	2	:	:	PUNCT
admet-292	1781	3	my	my	PRON
admet-292	1781	4	own	own	ADJ
admet-292	1781	5	inclination	inclination	NOUN
admet-292	1781	6	is	be	AUX
admet-292	1781	7	not	not	PART
admet-292	1781	8	to	to	PART
admet-292	1781	9	use	use	VERB
admet-292	1781	10	“	"	PUNCT
admet-292	1781	11	off	off	ADP
admet-292	1781	12	-	-	PUNCT
admet-292	1781	13	the	the	DET
admet-292	1781	14	-	-	PUNCT
admet-292	1781	15	shelf	shelf	NOUN
admet-292	1781	16	”	"	PUNCT
admet-292	1781	17	buffer	buffer	NOUN
admet-292	1781	18	recipes	recipe	NOUN
admet-292	1781	19	.	.	PUNCT
admet-292	1782	1	select	select	VERB
admet-292	1782	2	a	a	DET
admet-292	1782	3	buffer	buffer	NOUN
admet-292	1782	4	for	for	ADP
admet-292	1782	5	the	the	DET
admet-292	1782	6	job	job	NOUN
admet-292	1782	7	.	.	PUNCT
admet-292	1783	1	keep	keep	VERB
admet-292	1783	2	the	the	DET
admet-292	1783	3	solution	solution	NOUN
admet-292	1783	4	as	as	ADV
admet-292	1783	5	simple	simple	ADJ
admet-292	1783	6	as	as	ADP
admet-292	1783	7	possible	possible	ADJ
admet-292	1783	8	,	,	PUNCT
admet-292	1783	9	and	and	CCONJ
admet-292	1783	10	avoid	avoid	VERB
admet-292	1783	11	unintended	unintended	ADJ
admet-292	1783	12	buffer	buffer	NOUN
admet-292	1783	13	-	-	PUNCT
admet-292	1783	14	drug	drug	NOUN
admet-292	1783	15	interactions	interaction	NOUN
admet-292	1783	16	.	.	PUNCT
admet-292	1784	1	also	also	ADV
admet-292	1784	2	,	,	PUNCT
admet-292	1784	3	keep	keep	VERB
admet-292	1784	4	the	the	DET
admet-292	1784	5	ionic	ionic	ADJ
admet-292	1784	6	strength	strength	NOUN
admet-292	1784	7	controlled	control	VERB
admet-292	1784	8	.	.	PUNCT
admet-292	1785	1	of	of	ADP
admet-292	1785	2	course	course	NOUN
admet-292	1785	3	,	,	PUNCT
admet-292	1785	4	that	that	PRON
admet-292	1785	5	requires	require	VERB
admet-292	1785	6	some	some	DET
admet-292	1785	7	experience	experience	NOUN
admet-292	1785	8	.	.	PUNCT
admet-292	1786	1	there	there	PRON
admet-292	1786	2	is	be	VERB
admet-292	1786	3	a	a	DET
admet-292	1786	4	lot	lot	NOUN
admet-292	1786	5	more	more	ADJ
admet-292	1786	6	to	to	PART
admet-292	1786	7	be	be	AUX
admet-292	1786	8	said	say	VERB
admet-292	1786	9	about	about	ADP
admet-292	1786	10	buffers	buffer	NOUN
admet-292	1786	11	.	.	PUNCT
admet-292	1787	1	q	q	X
admet-292	1787	2	:	:	PUNCT
admet-292	1787	3	last	last	ADJ
admet-292	1787	4	question	question	NOUN
admet-292	1787	5	is	be	AUX
admet-292	1787	6	about	about	ADP
admet-292	1787	7	ionic	ionic	ADJ
admet-292	1787	8	strength	strength	NOUN
admet-292	1787	9	.	.	PUNCT
admet-292	1788	1	ionic	ionic	ADJ
admet-292	1788	2	strength	strength	NOUN
admet-292	1788	3	of	of	ADP
admet-292	1788	4	buffer	buffer	NOUN
admet-292	1788	5	should	should	AUX
admet-292	1788	6	be	be	AUX
admet-292	1788	7	0.15	0.15	NUM
admet-292	1788	8	m.	m.	NOUN
admet-292	1788	9	is	be	AUX
admet-292	1788	10	it	it	PRON
admet-292	1788	11	better	well	ADJ
admet-292	1788	12	use	use	VERB
admet-292	1788	13	for	for	ADP
admet-292	1788	14	fixation	fixation	NOUN
admet-292	1788	15	kcl	kcl	NOUN
admet-292	1788	16	or	or	CCONJ
admet-292	1788	17	nacl	nacl	NOUN
admet-292	1788	18	?	?	PUNCT
admet-292	1789	1	usually	usually	ADV
admet-292	1789	2	nacl	nacl	NOUN
admet-292	1789	3	has	have	AUX
admet-292	1789	4	been	be	AUX
admet-292	1789	5	used	use	VERB
admet-292	1789	6	,	,	PUNCT
admet-292	1789	7	but	but	CCONJ
admet-292	1789	8	in	in	ADP
admet-292	1789	9	your	your	PRON
admet-292	1789	10	book	book	NOUN
admet-292	1789	11	(	(	PUNCT
admet-292	1789	12	paragraph	paragraph	NOUN
admet-292	1789	13	:	:	PUNCT
admet-292	1789	14	pka	pka	PROPN
admet-292	1789	15	determination	determination	NOUN
admet-292	1789	16	)	)	PUNCT
admet-292	1789	17	is	be	AUX
admet-292	1789	18	used	use	VERB
admet-292	1789	19	kcl	kcl	PROPN
admet-292	1789	20	.	.	PUNCT
admet-292	1790	1	i	i	PRON
admet-292	1790	2	have	have	AUX
admet-292	1790	3	already	already	ADV
admet-292	1790	4	noticed	notice	VERB
admet-292	1790	5	that	that	SCONJ
admet-292	1790	6	sds	sds	PROPN
admet-292	1790	7	and	and	CCONJ
admet-292	1790	8	kcl	kcl	PROPN
admet-292	1790	9	ca	can	AUX
admet-292	1790	10	n't	not	PART
admet-292	1790	11	put	put	VERB
admet-292	1790	12	together	together	ADV
admet-292	1790	13	to	to	ADP
admet-292	1790	14	the	the	DET
admet-292	1790	15	solution	solution	NOUN
admet-292	1790	16	,	,	PUNCT
admet-292	1790	17	so	so	CCONJ
admet-292	1790	18	i	i	PRON
admet-292	1790	19	'm	be	AUX
admet-292	1790	20	little	little	ADV
admet-292	1790	21	worried	worried	ADJ
admet-292	1790	22	that	that	SCONJ
admet-292	1790	23	maybe	maybe	ADV
admet-292	1790	24	different	different	ADJ
admet-292	1790	25	salts	salt	NOUN
admet-292	1790	26	(	(	PUNCT
admet-292	1790	27	same	same	ADJ
admet-292	1790	28	admet	admet	NOUN
admet-292	1790	29	&	&	CCONJ
admet-292	1790	30	dmpk	dmpk	PROPN
admet-292	1790	31	4(2	4(2	NUM
admet-292	1790	32	)	)	PUNCT
admet-292	1790	33	(	(	PUNCT
admet-292	1790	34	2016	2016	NUM
admet-292	1790	35	)	)	PUNCT
admet-292	1790	36	117	117	NUM
admet-292	1790	37	-	-	SYM
admet-292	1790	38	178	178	NUM
admet-292	1790	39	consensus	consensus	NOUN
admet-292	1790	40	recommendations	recommendation	NOUN
admet-292	1790	41	for	for	ADP
admet-292	1790	42	improving	improve	VERB
admet-292	1790	43	solubility	solubility	NOUN
admet-292	1790	44	-	-	PUNCT
admet-292	1790	45	ph	ph	ADJ
admet-292	1790	46	data	datum	NOUN
admet-292	1790	47	quality	quality	NOUN
admet-292	1790	48	doi	doi	NOUN
admet-292	1790	49	:	:	PUNCT
admet-292	1790	50	10.5599	10.5599	NUM
admet-292	1790	51	/	/	SYM
admet-292	1790	52	admet.4.2.292	admet.4.2.292	NUM
admet-292	1790	53	177	177	NUM
admet-292	1790	54	concentration	concentration	NOUN
admet-292	1790	55	)	)	PUNCT
admet-292	1790	56	can	can	AUX
admet-292	1790	57	influence	influence	VERB
admet-292	1790	58	solubility	solubility	NOUN
admet-292	1790	59	of	of	ADP
admet-292	1790	60	some	some	DET
admet-292	1790	61	compounds	compound	NOUN
admet-292	1790	62	.	.	PUNCT
admet-292	1791	1	[	[	X
admet-292	1791	2	this	this	PRON
admet-292	1791	3	is	be	AUX
admet-292	1791	4	]	]	PUNCT
admet-292	1791	5	one	one	NUM
admet-292	1791	6	more	more	ADJ
admet-292	1791	7	thing	thing	NOUN
admet-292	1791	8	which	which	PRON
admet-292	1791	9	is	be	AUX
admet-292	1791	10	not	not	PART
admet-292	1791	11	yet	yet	ADV
admet-292	1791	12	clear	clear	ADJ
admet-292	1791	13	for	for	ADP
admet-292	1791	14	me	i	PRON
admet-292	1791	15	.	.	PUNCT
admet-292	1792	1	if	if	SCONJ
admet-292	1792	2	i	i	PRON
admet-292	1792	3	use	use	VERB
admet-292	1792	4	buffer	buffer	NOUN
admet-292	1792	5	with	with	ADP
admet-292	1792	6	fixed	fix	VERB
admet-292	1792	7	ionic	ionic	ADJ
admet-292	1792	8	strength	strength	NOUN
admet-292	1792	9	,	,	PUNCT
admet-292	1792	10	then	then	ADV
admet-292	1792	11	final	final	ADJ
admet-292	1792	12	ionic	ionic	ADJ
admet-292	1792	13	strength	strength	NOUN
admet-292	1792	14	for	for	ADP
admet-292	1792	15	solubility	solubility	NOUN
admet-292	1792	16	assay	assay	NOUN
admet-292	1792	17	will	will	AUX
admet-292	1792	18	be	be	AUX
admet-292	1792	19	very	very	ADV
admet-292	1792	20	different	different	ADJ
admet-292	1792	21	for	for	ADP
admet-292	1792	22	different	different	ADJ
admet-292	1792	23	compounds	compound	NOUN
admet-292	1792	24	.	.	PUNCT
admet-292	1793	1	can	can	AUX
admet-292	1793	2	it	it	PRON
admet-292	1793	3	influence	influence	VERB
admet-292	1793	4	the	the	DET
admet-292	1793	5	solubility	solubility	NOUN
admet-292	1793	6	value	value	NOUN
admet-292	1793	7	?	?	PUNCT
admet-292	1794	1	is	be	AUX
admet-292	1794	2	it	it	PRON
admet-292	1794	3	better	well	ADV
admet-292	1794	4	firstly	firstly	ADV
admet-292	1794	5	estimate	estimate	VERB
admet-292	1794	6	solubility	solubility	NOUN
admet-292	1794	7	value	value	NOUN
admet-292	1794	8	and	and	CCONJ
admet-292	1794	9	then	then	ADV
admet-292	1794	10	use	use	VERB
admet-292	1794	11	this	this	DET
admet-292	1794	12	value	value	NOUN
admet-292	1794	13	for	for	ADP
admet-292	1794	14	ionic	ionic	ADJ
admet-292	1794	15	strength	strength	NOUN
admet-292	1794	16	calculation	calculation	NOUN
admet-292	1794	17	to	to	PART
admet-292	1794	18	obtain	obtain	VERB
admet-292	1794	19	final	final	ADJ
admet-292	1794	20	ionic	ionic	ADJ
admet-292	1794	21	strength	strength	NOUN
admet-292	1794	22	value	value	NOUN
admet-292	1794	23	near	near	ADP
admet-292	1794	24	to	to	ADP
admet-292	1794	25	0.15	0.15	NUM
admet-292	1794	26	m	m	NOUN
admet-292	1794	27	?	?	PUNCT
admet-292	1795	1	or	or	CCONJ
admet-292	1795	2	it	it	PRON
admet-292	1795	3	is	be	AUX
admet-292	1795	4	not	not	PART
admet-292	1795	5	a	a	DET
admet-292	1795	6	problem	problem	NOUN
admet-292	1795	7	that	that	SCONJ
admet-292	1795	8	for	for	ADP
admet-292	1795	9	different	different	ADJ
admet-292	1795	10	compounds	compound	NOUN
admet-292	1795	11	ionic	ionic	ADJ
admet-292	1795	12	strength	strength	NOUN
admet-292	1795	13	will	will	AUX
admet-292	1795	14	be	be	AUX
admet-292	1795	15	different	different	ADJ
admet-292	1795	16	?	?	PUNCT
admet-292	1796	1	a1	a1	NOUN
admet-292	1796	2	:	:	PUNCT
admet-292	1796	3	for	for	ADP
admet-292	1796	4	solubility	solubility	NOUN
admet-292	1796	5	measurement	measurement	NOUN
admet-292	1796	6	,	,	PUNCT
admet-292	1796	7	nacl	nacl	NOUN
admet-292	1796	8	seems	seem	VERB
admet-292	1796	9	to	to	PART
admet-292	1796	10	be	be	AUX
admet-292	1796	11	popular	popular	ADJ
admet-292	1796	12	.	.	PUNCT
admet-292	1797	1	(	(	PUNCT
admet-292	1797	2	we	we	PRON
admet-292	1797	3	have	have	AUX
admet-292	1797	4	seen	see	VERB
admet-292	1797	5	the	the	DET
admet-292	1797	6	k	k	PROPN
admet-292	1797	7	+	+	PROPN
admet-292	1797	8	+	+	CCONJ
admet-292	1797	9	sds	sds	PROPN
admet-292	1797	10	precipitation	precipitation	NOUN
admet-292	1797	11	,	,	PUNCT
admet-292	1797	12	too	too	ADV
admet-292	1797	13	.	.	PUNCT
admet-292	1797	14	)	)	PUNCT
admet-292	1798	1	ideally	ideally	ADV
admet-292	1798	2	,	,	PUNCT
admet-292	1798	3	you	you	PRON
admet-292	1798	4	want	want	VERB
admet-292	1798	5	the	the	DET
admet-292	1798	6	final	final	ADJ
admet-292	1798	7	solution	solution	NOUN
admet-292	1798	8	to	to	PART
admet-292	1798	9	be	be	AUX
admet-292	1798	10	mimicking	mimic	VERB
admet-292	1798	11	the	the	DET
admet-292	1798	12	physiological	physiological	ADJ
admet-292	1798	13	ionic	ionic	ADJ
admet-292	1798	14	strength	strength	NOUN
admet-292	1798	15	,	,	PUNCT
admet-292	1798	16	0.15	0.15	NUM
admet-292	1798	17	m.	m.	NOUN
admet-292	1798	18	but	but	CCONJ
admet-292	1798	19	,	,	PUNCT
admet-292	1798	20	sample	sample	NOUN
admet-292	1798	21	and	and	CCONJ
admet-292	1798	22	buffer	buffer	NOUN
admet-292	1798	23	will	will	AUX
admet-292	1798	24	alter	alter	VERB
admet-292	1798	25	that	that	DET
admet-292	1798	26	value	value	NOUN
admet-292	1798	27	.	.	PUNCT
admet-292	1799	1	a	a	DET
admet-292	1799	2	simulation	simulation	NOUN
admet-292	1799	3	using	use	VERB
admet-292	1799	4	some	some	DET
admet-292	1799	5	program	program	NOUN
admet-292	1799	6	(	(	PUNCT
admet-292	1799	7	e.g.	e.g.	ADV
admet-292	1799	8	,	,	PUNCT
admet-292	1799	9	pdisol	pdisol	ADJ
admet-292	1799	10	-	-	PUNCT
admet-292	1799	11	x	x	NOUN
admet-292	1799	12	)	)	PUNCT
admet-292	1799	13	would	would	AUX
admet-292	1799	14	be	be	AUX
admet-292	1799	15	helpful	helpful	ADJ
admet-292	1799	16	.	.	PUNCT
admet-292	1800	1	when	when	SCONJ
admet-292	1800	2	studying	study	VERB
admet-292	1800	3	salts	salt	NOUN
admet-292	1800	4	,	,	PUNCT
admet-292	1800	5	it	it	PRON
admet-292	1800	6	is	be	AUX
admet-292	1800	7	not	not	PART
admet-292	1800	8	easy	easy	ADJ
admet-292	1800	9	to	to	PART
admet-292	1800	10	keep	keep	VERB
admet-292	1800	11	the	the	DET
admet-292	1800	12	ionic	ionic	ADJ
admet-292	1800	13	strength	strength	NOUN
admet-292	1800	14	at	at	ADP
admet-292	1800	15	the	the	DET
admet-292	1800	16	physiological	physiological	ADJ
admet-292	1800	17	level	level	NOUN
admet-292	1800	18	,	,	PUNCT
admet-292	1800	19	due	due	ADP
admet-292	1800	20	to	to	ADP
admet-292	1800	21	the	the	DET
admet-292	1800	22	excessive	excessive	ADJ
admet-292	1800	23	sample	sample	NOUN
admet-292	1800	24	added	add	VERB
admet-292	1800	25	.	.	PUNCT
admet-292	1801	1	a2	a2	PROPN
admet-292	1801	2	:	:	PUNCT
admet-292	1801	3	we	we	PRON
admet-292	1801	4	do	do	AUX
admet-292	1801	5	not	not	PART
admet-292	1801	6	use	use	VERB
admet-292	1801	7	extra	extra	ADJ
admet-292	1801	8	salt	salt	NOUN
admet-292	1801	9	to	to	PART
admet-292	1801	10	keep	keep	VERB
admet-292	1801	11	the	the	DET
admet-292	1801	12	ionic	ionic	ADJ
admet-292	1801	13	strength	strength	NOUN
admet-292	1801	14	constant	constant	ADJ
admet-292	1801	15	.	.	PUNCT
admet-292	1802	1	q	q	X
admet-292	1802	2	:	:	PUNCT
admet-292	1802	3	why	why	SCONJ
admet-292	1802	4	should	should	AUX
admet-292	1802	5	wetting	wet	VERB
admet-292	1802	6	be	be	AUX
admet-292	1802	7	a	a	DET
admet-292	1802	8	problem	problem	NOUN
admet-292	1802	9	in	in	ADP
admet-292	1802	10	sonic	sonic	ADJ
admet-292	1802	11	bath	bath	NOUN
admet-292	1802	12	?	?	PUNCT
admet-292	1803	1	if	if	SCONJ
admet-292	1803	2	compound	compound	NOUN
admet-292	1803	3	wet	wet	ADJ
admet-292	1803	4	very	very	ADV
admet-292	1803	5	easily	easily	ADV
admet-292	1803	6	,	,	PUNCT
admet-292	1803	7	then	then	ADV
admet-292	1803	8	it	it	PRON
admet-292	1803	9	should	should	AUX
admet-292	1803	10	dissolve	dissolve	VERB
admet-292	1803	11	quickly	quickly	ADV
admet-292	1803	12	,	,	PUNCT
admet-292	1803	13	because	because	SCONJ
admet-292	1803	14	compound	compound	NOUN
admet-292	1803	15	will	will	AUX
admet-292	1803	16	be	be	AUX
admet-292	1803	17	in	in	ADP
admet-292	1803	18	contact	contact	NOUN
admet-292	1803	19	to	to	ADP
admet-292	1803	20	water	water	NOUN
admet-292	1803	21	.	.	PUNCT
admet-292	1804	1	and	and	CCONJ
admet-292	1804	2	when	when	SCONJ
admet-292	1804	3	compound	compound	NOUN
admet-292	1804	4	is	be	AUX
admet-292	1804	5	poorly	poorly	ADV
admet-292	1804	6	wettable	wettable	ADJ
admet-292	1804	7	,	,	PUNCT
admet-292	1804	8	then	then	ADV
admet-292	1804	9	sonic	sonic	ADJ
admet-292	1804	10	should	should	AUX
admet-292	1804	11	help	help	VERB
admet-292	1804	12	to	to	PART
admet-292	1804	13	wet	wet	VERB
admet-292	1804	14	the	the	DET
admet-292	1804	15	compound	compound	NOUN
admet-292	1804	16	,	,	PUNCT
admet-292	1804	17	because	because	SCONJ
admet-292	1804	18	then	then	ADV
admet-292	1804	19	molecules	molecule	NOUN
admet-292	1804	20	will	will	AUX
admet-292	1804	21	move	move	VERB
admet-292	1804	22	more	more	ADV
admet-292	1804	23	quickly	quickly	ADV
admet-292	1804	24	than	than	ADP
admet-292	1804	25	usual	usual	ADJ
admet-292	1804	26	stirring	stirring	NOUN
admet-292	1804	27	experiment	experiment	NOUN
admet-292	1804	28	.	.	PUNCT
admet-292	1805	1	the	the	DET
admet-292	1805	2	idea	idea	NOUN
admet-292	1805	3	to	to	PART
admet-292	1805	4	use	use	VERB
admet-292	1805	5	ultrasonic	ultrasonic	ADJ
admet-292	1805	6	bath	bath	NOUN
admet-292	1805	7	feels	feel	VERB
admet-292	1805	8	more	more	ADV
admet-292	1805	9	easily	easily	ADV
admet-292	1805	10	performable	performable	ADJ
admet-292	1805	11	than	than	SCONJ
admet-292	1805	12	construct	construct	VERB
admet-292	1805	13	some	some	DET
admet-292	1805	14	device	device	NOUN
admet-292	1805	15	,	,	PUNCT
admet-292	1805	16	where	where	SCONJ
admet-292	1805	17	i	i	PRON
admet-292	1805	18	can	can	AUX
admet-292	1805	19	mix	mix	VERB
admet-292	1805	20	many	many	ADJ
admet-292	1805	21	samples	sample	NOUN
admet-292	1805	22	same	same	ADJ
admet-292	1805	23	time	time	NOUN
admet-292	1805	24	.	.	PUNCT
admet-292	1806	1	i	i	PRON
admet-292	1806	2	think	think	VERB
admet-292	1806	3	that	that	SCONJ
admet-292	1806	4	if	if	SCONJ
admet-292	1806	5	i	i	PRON
admet-292	1806	6	could	could	AUX
admet-292	1806	7	use	use	VERB
admet-292	1806	8	ultrasonic	ultrasonic	ADJ
admet-292	1806	9	bath	bath	NOUN
admet-292	1806	10	,	,	PUNCT
admet-292	1806	11	then	then	ADV
admet-292	1806	12	i	i	PRON
admet-292	1806	13	would	would	AUX
admet-292	1806	14	n't	not	PART
admet-292	1806	15	need	need	VERB
admet-292	1806	16	any	any	DET
admet-292	1806	17	stirrer	stirrer	NOUN
admet-292	1806	18	in	in	ADP
admet-292	1806	19	the	the	DET
admet-292	1806	20	solution	solution	NOUN
admet-292	1806	21	,	,	PUNCT
admet-292	1806	22	which	which	PRON
admet-292	1806	23	will	will	AUX
admet-292	1806	24	make	make	VERB
admet-292	1806	25	the	the	DET
admet-292	1806	26	system	system	NOUN
admet-292	1806	27	simpler	simple	ADJ
admet-292	1806	28	and	and	CCONJ
admet-292	1806	29	no	no	DET
admet-292	1806	30	extra	extra	ADJ
admet-292	1806	31	thing	thing	NOUN
admet-292	1806	32	will	will	AUX
admet-292	1806	33	be	be	AUX
admet-292	1806	34	in	in	ADP
admet-292	1806	35	solution	solution	NOUN
admet-292	1806	36	,	,	PUNCT
admet-292	1806	37	which	which	PRON
admet-292	1806	38	should	should	AUX
admet-292	1806	39	be	be	AUX
admet-292	1806	40	good	good	ADJ
admet-292	1806	41	thing	thing	NOUN
admet-292	1806	42	.	.	PUNCT
admet-292	1807	1	a1	a1	NOUN
admet-292	1807	2	:	:	PUNCT
admet-292	1807	3	if	if	SCONJ
admet-292	1807	4	a	a	DET
admet-292	1807	5	compound	compound	NOUN
admet-292	1807	6	does	do	AUX
admet-292	1807	7	not	not	PART
admet-292	1807	8	wet	wet	VERB
admet-292	1807	9	very	very	ADV
admet-292	1807	10	well	well	ADV
admet-292	1807	11	,	,	PUNCT
admet-292	1807	12	it	it	PRON
admet-292	1807	13	just	just	ADV
admet-292	1807	14	floats	float	VERB
admet-292	1807	15	on	on	ADP
admet-292	1807	16	the	the	DET
admet-292	1807	17	vibrating	vibrate	VERB
admet-292	1807	18	water	water	NOUN
admet-292	1807	19	surface	surface	NOUN
admet-292	1807	20	,	,	PUNCT
admet-292	1807	21	just	just	ADV
admet-292	1807	22	like	like	ADP
admet-292	1807	23	a	a	DET
admet-292	1807	24	feather	feather	NOUN
admet-292	1807	25	from	from	ADP
admet-292	1807	26	a	a	DET
admet-292	1807	27	duck	duck	NOUN
admet-292	1807	28	,	,	PUNCT
admet-292	1807	29	especially	especially	ADV
admet-292	1807	30	one	one	NUM
admet-292	1807	31	coated	coat	VERB
admet-292	1807	32	with	with	ADP
admet-292	1807	33	soot	soot	NOUN
admet-292	1807	34	.	.	PUNCT
admet-292	1808	1	i	i	PRON
admet-292	1808	2	think	think	VERB
admet-292	1808	3	just	just	ADV
admet-292	1808	4	a	a	DET
admet-292	1808	5	single	single	ADJ
admet-292	1808	6	drop	drop	NOUN
admet-292	1808	7	of	of	ADP
admet-292	1808	8	methanol	methanol	NOUN
admet-292	1808	9	on	on	ADP
admet-292	1808	10	top	top	NOUN
admet-292	1808	11	of	of	ADP
admet-292	1808	12	the	the	DET
admet-292	1808	13	crystals	crystal	NOUN
admet-292	1808	14	would	would	AUX
admet-292	1808	15	cause	cause	VERB
admet-292	1808	16	them	they	PRON
admet-292	1808	17	to	to	AUX
admet-292	1808	18	wet	wet	VERB
admet-292	1808	19	(	(	PUNCT
admet-292	1808	20	and	and	CCONJ
admet-292	1808	21	dissolve	dissolve	VERB
admet-292	1808	22	)	)	PUNCT
admet-292	1808	23	,	,	PUNCT
admet-292	1808	24	before	before	SCONJ
admet-292	1808	25	the	the	DET
admet-292	1808	26	buffer	buffer	NOUN
admet-292	1808	27	is	be	AUX
admet-292	1808	28	added	add	VERB
admet-292	1808	29	.	.	PUNCT
admet-292	1809	1	i	i	PRON
admet-292	1809	2	think	think	VERB
admet-292	1809	3	the	the	DET
admet-292	1809	4	main	main	ADJ
admet-292	1809	5	concern	concern	NOUN
admet-292	1809	6	about	about	ADP
admet-292	1809	7	sonic	sonic	ADJ
admet-292	1809	8	bath	bath	NOUN
admet-292	1809	9	is	be	AUX
admet-292	1809	10	that	that	SCONJ
admet-292	1809	11	it	it	PRON
admet-292	1809	12	may	may	AUX
admet-292	1809	13	lead	lead	VERB
admet-292	1809	14	to	to	ADP
admet-292	1809	15	(	(	PUNCT
admet-292	1809	16	superstable	superstable	ADJ
admet-292	1809	17	)	)	PUNCT
admet-292	1809	18	supersaturation	supersaturation	NOUN
admet-292	1809	19	effects	effect	NOUN
admet-292	1809	20	.	.	PUNCT
admet-292	1810	1	perhaps	perhaps	ADV
admet-292	1810	2	others	other	NOUN
admet-292	1810	3	have	have	VERB
admet-292	1810	4	experience	experience	NOUN
admet-292	1810	5	with	with	ADP
admet-292	1810	6	this	this	PRON
admet-292	1810	7	?	?	PUNCT
admet-292	1811	1	q	q	NOUN
admet-292	1811	2	:	:	PUNCT
admet-292	1811	3	i	i	PRON
admet-292	1811	4	agree	agree	VERB
admet-292	1811	5	that	that	SCONJ
admet-292	1811	6	[	[	X
admet-292	1811	7	it	it	PRON
admet-292	1811	8	is	be	AUX
admet-292	1811	9	]	]	PUNCT
admet-292	1811	10	better	well	ADJ
admet-292	1811	11	[	[	X
admet-292	1811	12	to	to	PART
admet-292	1811	13	]	]	PUNCT
admet-292	1811	14	predict	predict	VERB
admet-292	1811	15	solubility	solubility	NOUN
admet-292	1811	16	before	before	ADP
admet-292	1811	17	experiment	experiment	NOUN
admet-292	1811	18	and	and	CCONJ
admet-292	1811	19	at	at	ADP
admet-292	1811	20	least	least	ADJ
admet-292	1811	21	know	know	VERB
admet-292	1811	22	something	something	PRON
admet-292	1811	23	about	about	ADP
admet-292	1811	24	the	the	DET
admet-292	1811	25	compound	compound	NOUN
admet-292	1811	26	.	.	PUNCT
admet-292	1812	1	i	i	PRON
admet-292	1812	2	will	will	AUX
admet-292	1812	3	try	try	VERB
admet-292	1812	4	to	to	PART
admet-292	1812	5	perform	perform	VERB
admet-292	1812	6	the	the	DET
admet-292	1812	7	experiment	experiment	NOUN
admet-292	1812	8	as	as	SCONJ
admet-292	1812	9	you	you	PRON
admet-292	1812	10	suggest	suggest	VERB
admet-292	1812	11	:	:	PUNCT
admet-292	1812	12	first	first	ADV
admet-292	1812	13	add	add	VERB
admet-292	1812	14	a	a	DET
admet-292	1812	15	certain	certain	ADJ
admet-292	1812	16	amount	amount	NOUN
admet-292	1812	17	compound	compound	NOUN
admet-292	1812	18	,	,	PUNCT
admet-292	1812	19	and	and	CCONJ
admet-292	1812	20	if	if	SCONJ
admet-292	1812	21	needed	need	VERB
admet-292	1812	22	,	,	PUNCT
admet-292	1812	23	then	then	ADV
admet-292	1812	24	add	add	VERB
admet-292	1812	25	more	more	ADJ
admet-292	1812	26	by	by	ADP
admet-292	1812	27	weighting	weight	VERB
admet-292	1812	28	.	.	PUNCT
admet-292	1813	1	is	be	AUX
admet-292	1813	2	it	it	PRON
admet-292	1813	3	possible	possible	ADJ
admet-292	1813	4	to	to	PART
admet-292	1813	5	get	get	VERB
admet-292	1813	6	access	access	NOUN
admet-292	1813	7	to	to	ADP
admet-292	1813	8	pdisol	pdisol	ADJ
admet-292	1813	9	-	-	PUNCT
admet-292	1813	10	x	x	NOUN
admet-292	1813	11	software	software	NOUN
admet-292	1813	12	and	and	CCONJ
admet-292	1813	13	license	license	NOUN
admet-292	1813	14	?	?	PUNCT
admet-292	1814	1	i	i	PRON
admet-292	1814	2	think	think	VERB
admet-292	1814	3	it	it	PRON
admet-292	1814	4	is	be	AUX
admet-292	1814	5	important	important	ADJ
admet-292	1814	6	to	to	PART
admet-292	1814	7	use	use	VERB
admet-292	1814	8	this	this	DET
admet-292	1814	9	program	program	NOUN
admet-292	1814	10	before	before	ADP
admet-292	1814	11	experiment	experiment	NOUN
admet-292	1814	12	,	,	PUNCT
admet-292	1814	13	because	because	SCONJ
admet-292	1814	14	this	this	PRON
admet-292	1814	15	will	will	AUX
admet-292	1814	16	make	make	VERB
admet-292	1814	17	easier	easy	ADJ
admet-292	1814	18	to	to	PART
admet-292	1814	19	perform	perform	VERB
admet-292	1814	20	correct	correct	ADJ
admet-292	1814	21	solutions	solution	NOUN
admet-292	1814	22	quicker	quick	ADV
admet-292	1814	23	.	.	PUNCT
admet-292	1815	1	this	this	PRON
admet-292	1815	2	is	be	AUX
admet-292	1815	3	certain	certain	ADJ
admet-292	1815	4	that	that	SCONJ
admet-292	1815	5	i	i	PRON
admet-292	1815	6	will	will	AUX
admet-292	1815	7	avoid	avoid	VERB
admet-292	1815	8	dmso	dmso	NOUN
admet-292	1815	9	,	,	PUNCT
admet-292	1815	10	because	because	SCONJ
admet-292	1815	11	i	i	PRON
admet-292	1815	12	wish	wish	VERB
admet-292	1815	13	to	to	PART
admet-292	1815	14	measure	measure	VERB
admet-292	1815	15	only	only	ADJ
admet-292	1815	16	water	water	NOUN
admet-292	1815	17	solubility	solubility	NOUN
admet-292	1815	18	,	,	PUNCT
admet-292	1815	19	not	not	PART
admet-292	1815	20	solubility	solubility	NOUN
admet-292	1815	21	for	for	ADP
admet-292	1815	22	mixture	mixture	NOUN
admet-292	1815	23	(	(	PUNCT
admet-292	1815	24	water	water	NOUN
admet-292	1815	25	and	and	CCONJ
admet-292	1815	26	dmso	dmso	NOUN
admet-292	1815	27	)	)	PUNCT
admet-292	1815	28	.	.	PUNCT
admet-292	1816	1	a1	a1	NOUN
admet-292	1816	2	:	:	PUNCT
admet-292	1816	3	heath	heath	NOUN
admet-292	1816	4	scientific	scientific	ADJ
admet-292	1816	5	(	(	PUNCT
admet-292	1816	6	uk	uk	PROPN
admet-292	1816	7	)	)	PUNCT
admet-292	1816	8	is	be	AUX
admet-292	1816	9	the	the	DET
admet-292	1816	10	distributor	distributor	NOUN
admet-292	1816	11	in	in	ADP
admet-292	1816	12	the	the	DET
admet-292	1816	13	eu	eu	PROPN
admet-292	1816	14	:	:	PUNCT
admet-292	1816	15	steve.stones@heathscientific.com	steve.stones@heathscientific.com	X
admet-292	1816	16	.	.	PUNCT
admet-292	1817	1	a	a	DET
admet-292	1817	2	30	30	NUM
admet-292	1817	3	-	-	PUNCT
admet-292	1817	4	day	day	NOUN
admet-292	1817	5	free	free	ADJ
admet-292	1817	6	trial	trial	NOUN
admet-292	1817	7	is	be	AUX
admet-292	1817	8	available	available	ADJ
admet-292	1817	9	.	.	PUNCT
admet-292	1818	1	q	q	X
admet-292	1818	2	:	:	PUNCT
admet-292	1818	3	i	i	PRON
admet-292	1818	4	forgot	forget	VERB
admet-292	1818	5	that	that	SCONJ
admet-292	1818	6	i	i	PRON
admet-292	1818	7	have	have	VERB
admet-292	1818	8	this	this	DET
admet-292	1818	9	poster	poster	NOUN
admet-292	1818	10	printout	printout	NOUN
admet-292	1818	11	.	.	PUNCT
admet-292	1819	1	i	i	PRON
admet-292	1819	2	analyzed	analyze	VERB
admet-292	1819	3	her	her	PRON
admet-292	1819	4	data	datum	NOUN
admet-292	1819	5	and	and	CCONJ
admet-292	1819	6	i	i	PRON
admet-292	1819	7	found	find	VERB
admet-292	1819	8	that	that	SCONJ
admet-292	1819	9	maybe	maybe	ADV
admet-292	1819	10	it	it	PRON
admet-292	1819	11	is	be	AUX
admet-292	1819	12	better	well	ADJ
admet-292	1819	13	not	not	PART
admet-292	1819	14	filter	filter	VERB
admet-292	1819	15	at	at	ADV
admet-292	1819	16	all	all	ADV
admet-292	1819	17	,	,	PUNCT
admet-292	1819	18	because	because	SCONJ
admet-292	1819	19	sedimentation	sedimentation	NOUN
admet-292	1819	20	will	will	AUX
admet-292	1819	21	give	give	VERB
admet-292	1819	22	usually	usually	ADV
admet-292	1819	23	higher	high	ADJ
admet-292	1819	24	solubility	solubility	NOUN
admet-292	1819	25	value	value	NOUN
admet-292	1819	26	than	than	ADP
admet-292	1819	27	filtration	filtration	NOUN
admet-292	1819	28	.	.	PUNCT
admet-292	1820	1	is	be	AUX
admet-292	1820	2	it	it	PRON
admet-292	1820	3	reasonable	reasonable	ADJ
admet-292	1820	4	to	to	PART
admet-292	1820	5	do	do	VERB
admet-292	1820	6	this	this	PRON
admet-292	1820	7	?	?	PUNCT
admet-292	1821	1	i	i	PRON
admet-292	1821	2	think	think	VERB
admet-292	1821	3	filtration	filtration	NOUN
admet-292	1821	4	will	will	AUX
admet-292	1821	5	be	be	AUX
admet-292	1821	6	only	only	ADV
admet-292	1821	7	necessary	necessary	ADJ
admet-292	1821	8	for	for	ADP
admet-292	1821	9	compounds	compound	NOUN
admet-292	1821	10	which	which	PRON
admet-292	1821	11	have	have	VERB
admet-292	1821	12	problems	problem	NOUN
admet-292	1821	13	with	with	ADP
admet-292	1821	14	sedimentation	sedimentation	NOUN
admet-292	1821	15	.	.	PUNCT
admet-292	1822	1	a1	a1	PROPN
admet-292	1822	2	:	:	PUNCT
admet-292	1822	3	it	it	PRON
admet-292	1822	4	depends	depend	VERB
admet-292	1822	5	on	on	ADP
admet-292	1822	6	the	the	DET
admet-292	1822	7	type	type	NOUN
admet-292	1822	8	of	of	ADP
admet-292	1822	9	compound	compound	NOUN
admet-292	1822	10	.	.	PUNCT
admet-292	1823	1	some	some	DET
admet-292	1823	2	compounds	compound	NOUN
admet-292	1823	3	convert	convert	VERB
admet-292	1823	4	to	to	ADP
admet-292	1823	5	an	an	DET
admet-292	1823	6	oil	oil	NOUN
admet-292	1823	7	after	after	SCONJ
admet-292	1823	8	the	the	DET
admet-292	1823	9	crystals	crystal	NOUN
admet-292	1823	10	are	be	AUX
admet-292	1823	11	added	add	VERB
admet-292	1823	12	to	to	ADP
admet-292	1823	13	water	water	NOUN
admet-292	1823	14	.	.	PUNCT
admet-292	1824	1	most	most	ADJ
admet-292	1824	2	oils	oil	NOUN
admet-292	1824	3	do	do	AUX
admet-292	1824	4	n’t	not	PART
admet-292	1824	5	sediment	sediment	VERB
admet-292	1824	6	very	very	ADV
admet-292	1824	7	well	well	ADV
admet-292	1824	8	.	.	PUNCT
admet-292	1825	1	some	some	DET
admet-292	1825	2	surface	surface	NOUN
admet-292	1825	3	-	-	PUNCT
admet-292	1825	4	active	active	ADJ
admet-292	1825	5	compounds	compound	NOUN
admet-292	1825	6	form	form	VERB
admet-292	1825	7	colloid	colloid	NOUN
admet-292	1825	8	suspensions	suspension	NOUN
admet-292	1825	9	,	,	PUNCT
admet-292	1825	10	which	which	PRON
admet-292	1825	11	can	can	AUX
admet-292	1825	12	be	be	AUX
admet-292	1825	13	lyophilic	lyophilic	ADJ
admet-292	1825	14	(	(	PUNCT
admet-292	1825	15	e.g.	e.g.	ADV
admet-292	1825	16	,	,	PUNCT
admet-292	1825	17	gelatin	gelatin	NOUN
admet-292	1825	18	,	,	PUNCT
admet-292	1825	19	ranitidine	ranitidine	NOUN
admet-292	1825	20	,	,	PUNCT
admet-292	1825	21	guanosine	guanosine	NOUN
admet-292	1825	22	)	)	PUNCT
admet-292	1825	23	,	,	PUNCT
admet-292	1825	24	lyophobic	lyophobic	ADJ
admet-292	1825	25	(	(	PUNCT
admet-292	1825	26	e.g.	e.g.	ADV
admet-292	1826	1	,	,	PUNCT
admet-292	1826	2	some	some	DET
admet-292	1826	3	nanoparticles	nanoparticle	NOUN
admet-292	1826	4	)	)	PUNCT
admet-292	1826	5	,	,	PUNCT
admet-292	1826	6	or	or	CCONJ
admet-292	1826	7	associated	associate	VERB
admet-292	1826	8	(	(	PUNCT
admet-292	1826	9	e.g.	e.g.	ADV
admet-292	1826	10	,	,	PUNCT
admet-292	1826	11	“	"	PUNCT
admet-292	1826	12	llps	llp	NOUN
admet-292	1826	13	”	"	PUNCT
admet-292	1826	14	–	–	PUNCT
admet-292	1826	15	liquid	liquid	NOUN
admet-292	1826	16	-	-	PUNCT
admet-292	1826	17	liquid	liquid	NOUN
admet-292	1826	18	phase	phase	NOUN
admet-292	1826	19	separated	separate	VERB
admet-292	1826	20	,	,	PUNCT
admet-292	1826	21	like	like	ADP
admet-292	1826	22	some	some	DET
admet-292	1826	23	phenothiazines	phenothiazine	NOUN
admet-292	1826	24	–	–	PUNCT
admet-292	1826	25	cf	cf	NOUN
admet-292	1826	26	.	.	PUNCT
admet-292	1826	27	,	,	PUNCT
admet-292	1826	28	lynne	lynne	PROPN
admet-292	1826	29	taylor	taylor	PROPN
admet-292	1826	30	’s	’s	PART
admet-292	1826	31	work	work	NOUN
admet-292	1826	32	at	at	ADP
admet-292	1826	33	purdue	purdue	PROPN
admet-292	1826	34	university	university	NOUN
admet-292	1826	35	)	)	PUNCT
admet-292	1826	36	where	where	SCONJ
admet-292	1826	37	ultracentrifugation	ultracentrifugation	NOUN
admet-292	1826	38	is	be	AUX
admet-292	1826	39	recommended	recommend	VERB
admet-292	1826	40	for	for	ADP
admet-292	1826	41	separation	separation	NOUN
admet-292	1826	42	.	.	PUNCT
admet-292	1827	1	in	in	ADP
admet-292	1827	2	such	such	ADJ
admet-292	1827	3	cases	case	NOUN
admet-292	1827	4	,	,	PUNCT
admet-292	1827	5	it	it	PRON
admet-292	1827	6	may	may	AUX
admet-292	1827	7	be	be	AUX
admet-292	1827	8	useful	useful	ADJ
admet-292	1827	9	to	to	PART
admet-292	1827	10	filter	filter	VERB
admet-292	1827	11	carefully	carefully	ADV
admet-292	1827	12	first	first	ADV
admet-292	1827	13	,	,	PUNCT
admet-292	1827	14	and	and	CCONJ
admet-292	1827	15	then	then	ADV
admet-292	1827	16	ultracentrifuge	ultracentrifuge	ADJ
admet-292	1827	17	.	.	PUNCT
admet-292	1828	1	q	q	X
admet-292	1828	2	:	:	PUNCT
admet-292	1828	3	about	about	ADP
admet-292	1828	4	buffer	buffer	NOUN
admet-292	1828	5	:	:	PUNCT
admet-292	1828	6	is	be	AUX
admet-292	1828	7	it	it	PRON
admet-292	1828	8	correct	correct	ADJ
admet-292	1828	9	to	to	PART
admet-292	1828	10	use	use	VERB
admet-292	1828	11	different	different	ADJ
admet-292	1828	12	buffer	buffer	NOUN
admet-292	1828	13	system	system	NOUN
admet-292	1828	14	at	at	ADP
admet-292	1828	15	different	different	ADJ
admet-292	1828	16	phs	phs	NOUN
admet-292	1828	17	?	?	PUNCT
admet-292	1829	1	or	or	CCONJ
admet-292	1829	2	it	it	PRON
admet-292	1829	3	is	be	AUX
admet-292	1829	4	better	well	ADJ
admet-292	1829	5	to	to	PART
admet-292	1829	6	use	use	VERB
admet-292	1829	7	the	the	DET
admet-292	1829	8	same	same	ADJ
admet-292	1829	9	composition	composition	NOUN
admet-292	1829	10	buffer	buffer	NOUN
admet-292	1829	11	for	for	ADP
admet-292	1829	12	the	the	DET
admet-292	1829	13	different	different	ADJ
admet-292	1829	14	ph	ph	ADJ
admet-292	1829	15	values	value	NOUN
admet-292	1829	16	,	,	PUNCT
admet-292	1829	17	because	because	SCONJ
admet-292	1829	18	then	then	ADV
admet-292	1829	19	all	all	DET
admet-292	1829	20	effects	effect	NOUN
admet-292	1829	21	and	and	CCONJ
admet-292	1829	22	interactions	interaction	NOUN
admet-292	1829	23	between	between	ADP
admet-292	1829	24	compound	compound	NOUN
admet-292	1829	25	and	and	CCONJ
admet-292	1829	26	buffer	buffer	NOUN
admet-292	1829	27	components	component	NOUN
admet-292	1829	28	should	should	AUX
admet-292	1829	29	be	be	AUX
admet-292	1829	30	same	same	ADJ
admet-292	1829	31	.	.	PUNCT
admet-292	1830	1	i	i	PRON
admet-292	1830	2	agree	agree	VERB
admet-292	1830	3	that	that	SCONJ
admet-292	1830	4	ionic	ionic	ADJ
admet-292	1830	5	strength	strength	NOUN
admet-292	1830	6	should	should	AUX
admet-292	1830	7	be	be	AUX
admet-292	1830	8	controlled	control	VERB
admet-292	1830	9	and	and	CCONJ
admet-292	1830	10	if	if	SCONJ
admet-292	1830	11	i	i	PRON
admet-292	1830	12	'm	be	AUX
admet-292	1830	13	not	not	PART
admet-292	1830	14	wrong	wrong	ADJ
admet-292	1830	15	then	then	ADV
admet-292	1830	16	every	every	DET
admet-292	1830	17	ph	ph	NOUN
admet-292	1830	18	should	should	AUX
admet-292	1830	19	be	be	AUX
admet-292	1830	20	same	same	ADJ
admet-292	1830	21	ionic	ionic	ADJ
admet-292	1830	22	strength	strength	NOUN
admet-292	1830	23	.	.	PUNCT
admet-292	1831	1	it	it	PRON
admet-292	1831	2	means	mean	VERB
admet-292	1831	3	that	that	SCONJ
admet-292	1831	4	best	good	ADJ
admet-292	1831	5	buffer	buffer	NOUN
admet-292	1831	6	should	should	AUX
admet-292	1831	7	be	be	AUX
admet-292	1831	8	such	such	ADJ
admet-292	1831	9	which	which	PRON
admet-292	1831	10	has	have	VERB
admet-292	1831	11	constant	constant	ADJ
admet-292	1831	12	ionic	ionic	ADJ
admet-292	1831	13	strength	strength	NOUN
admet-292	1831	14	over	over	ADP
admet-292	1831	15	phrange	phrange	NOUN
admet-292	1831	16	or	or	CCONJ
admet-292	1831	17	then	then	ADV
admet-292	1831	18	at	at	ADP
admet-292	1831	19	different	different	ADJ
admet-292	1831	20	buffers	buffer	NOUN
admet-292	1831	21	for	for	ADP
admet-292	1831	22	different	different	ADJ
admet-292	1831	23	ph	ph	NOUN
admet-292	1831	24	-	-	PUNCT
admet-292	1831	25	s	s	NOUN
admet-292	1831	26	should	should	AUX
admet-292	1831	27	have	have	VERB
admet-292	1831	28	same	same	ADJ
admet-292	1831	29	ionic	ionic	ADJ
admet-292	1831	30	strength	strength	NOUN
admet-292	1831	31	.	.	PUNCT
admet-292	1832	1	is	be	AUX
admet-292	1832	2	it	it	PRON
admet-292	1832	3	correct	correct	ADJ
admet-292	1832	4	?	?	PUNCT
admet-292	1833	1	so	so	ADV
admet-292	1833	2	i	i	PRON
admet-292	1833	3	will	will	AUX
admet-292	1833	4	not	not	PART
admet-292	1833	5	add	add	VERB
admet-292	1833	6	any	any	DET
admet-292	1833	7	extra	extra	ADJ
admet-292	1833	8	salt	salt	NOUN
admet-292	1833	9	to	to	PART
admet-292	1833	10	buffer	buffer	VERB
admet-292	1833	11	,	,	PUNCT
admet-292	1833	12	since	since	SCONJ
admet-292	1833	13	the	the	DET
admet-292	1833	14	compound	compound	NOUN
admet-292	1833	15	contributions	contribution	NOUN
admet-292	1833	16	will	will	AUX
admet-292	1833	17	usually	usually	ADV
admet-292	1833	18	increase	increase	VERB
admet-292	1833	19	ionic	ionic	ADJ
admet-292	1833	20	strength	strength	NOUN
admet-292	1833	21	sufficiently	sufficiently	ADV
admet-292	1833	22	.	.	PUNCT
admet-292	1834	1	although	although	SCONJ
admet-292	1834	2	for	for	ADP
admet-292	1834	3	some	some	DET
admet-292	1834	4	low	low	ADJ
admet-292	1834	5	soluble	soluble	ADJ
admet-292	1834	6	compounds	compound	NOUN
admet-292	1834	7	it	it	PRON
admet-292	1834	8	will	will	AUX
admet-292	1834	9	be	be	AUX
admet-292	1834	10	important	important	ADJ
admet-292	1834	11	,	,	PUNCT
admet-292	1834	12	because	because	SCONJ
admet-292	1834	13	then	then	ADV
admet-292	1834	14	not	not	PART
admet-292	1834	15	enough	enough	ADJ
admet-292	1834	16	compound	compound	NOUN
admet-292	1834	17	will	will	AUX
admet-292	1834	18	be	be	AUX
admet-292	1834	19	in	in	ADP
admet-292	1834	20	solution	solution	NOUN
admet-292	1834	21	.	.	PUNCT
admet-292	1835	1	i	i	PRON
admet-292	1835	2	think	think	VERB
admet-292	1835	3	pdisol	pdisol	ADJ
admet-292	1835	4	-	-	PUNCT
admet-292	1835	5	x	x	NOUN
admet-292	1835	6	will	will	AUX
admet-292	1835	7	be	be	AUX
admet-292	1835	8	again	again	ADV
admet-292	1835	9	the	the	DET
admet-292	1835	10	solution	solution	NOUN
admet-292	1835	11	for	for	ADP
admet-292	1835	12	this	this	DET
admet-292	1835	13	problem	problem	NOUN
admet-292	1835	14	.	.	PUNCT
admet-292	1836	1	mailto:steve.stones@heathscientific.com	mailto:steve.stones@heathscientific.com	PROPN
admet-292	1836	2	alex	alex	PROPN
admet-292	1836	3	avdeef	avdeef	PROPN
admet-292	1836	4	et	et	PROPN
admet-292	1836	5	al	al	PROPN
admet-292	1836	6	.	.	PROPN
admet-292	1836	7	admet	admet	PROPN
admet-292	1836	8	&	&	CCONJ
admet-292	1836	9	dmpk	dmpk	PROPN
admet-292	1836	10	4(2	4(2	NUM
admet-292	1836	11	)	)	PUNCT
admet-292	1836	12	(	(	PUNCT
admet-292	1836	13	2016	2016	NUM
admet-292	1836	14	)	)	PUNCT
admet-292	1836	15	117	117	NUM
admet-292	1836	16	-	-	SYM
admet-292	1836	17	178	178	NUM
admet-292	1836	18	178	178	NUM
admet-292	1836	19	a1	a1	NOUN
admet-292	1836	20	:	:	PUNCT
admet-292	1836	21	this	this	PRON
admet-292	1836	22	is	be	AUX
admet-292	1836	23	a	a	DET
admet-292	1836	24	tough	tough	ADJ
admet-292	1836	25	but	but	CCONJ
admet-292	1836	26	good	good	ADJ
admet-292	1836	27	question	question	NOUN
admet-292	1836	28	.	.	PUNCT
admet-292	1837	1	i	i	PRON
admet-292	1837	2	have	have	AUX
admet-292	1837	3	done	do	VERB
admet-292	1837	4	a	a	DET
admet-292	1837	5	lot	lot	NOUN
admet-292	1837	6	of	of	ADP
admet-292	1837	7	simulation	simulation	NOUN
admet-292	1837	8	calculations	calculation	NOUN
admet-292	1837	9	on	on	ADP
admet-292	1837	10	a	a	DET
admet-292	1837	11	variety	variety	NOUN
admet-292	1837	12	of	of	ADP
admet-292	1837	13	drug	drug	NOUN
admet-292	1837	14	substance	substance	NOUN
admet-292	1837	15	solutions	solution	NOUN
admet-292	1837	16	,	,	PUNCT
admet-292	1837	17	to	to	PART
admet-292	1837	18	see	see	VERB
admet-292	1837	19	at	at	ADP
admet-292	1837	20	which	which	PRON
admet-292	1837	21	ph	ph	VERB
admet-292	1837	22	the	the	DET
admet-292	1837	23	buffer	buffer	NOUN
admet-292	1837	24	capacity	capacity	NOUN
admet-292	1837	25	is	be	AUX
admet-292	1837	26	low	low	ADJ
admet-292	1837	27	and	and	CCONJ
admet-292	1837	28	in	in	ADP
admet-292	1837	29	need	need	NOUN
admet-292	1837	30	of	of	ADP
admet-292	1837	31	external	external	ADJ
admet-292	1837	32	boosting	boosting	NOUN
admet-292	1837	33	.	.	PUNCT
admet-292	1838	1	it	it	PRON
admet-292	1838	2	is	be	AUX
admet-292	1838	3	not	not	PART
admet-292	1838	4	practical	practical	ADJ
admet-292	1838	5	to	to	PART
admet-292	1838	6	keep	keep	VERB
admet-292	1838	7	the	the	DET
admet-292	1838	8	ionic	ionic	ADJ
admet-292	1838	9	strength	strength	NOUN
admet-292	1838	10	exactly	exactly	ADV
admet-292	1838	11	constant	constant	ADJ
admet-292	1838	12	,	,	PUNCT
admet-292	1838	13	and	and	CCONJ
admet-292	1838	14	at	at	ADP
admet-292	1838	15	0.15	0.15	NUM
admet-292	1838	16	m.	m.	NOUN
admet-292	1838	17	the	the	DET
admet-292	1838	18	pdisol	pdisol	NOUN
admet-292	1838	19	-	-	PUNCT
admet-292	1838	20	x	x	NOUN
admet-292	1838	21	will	will	AUX
admet-292	1838	22	correct	correct	VERB
admet-292	1838	23	the	the	DET
admet-292	1838	24	equilibrium	equilibrium	NOUN
admet-292	1838	25	constants	constant	NOUN
admet-292	1838	26	and	and	CCONJ
admet-292	1838	27	the	the	DET
admet-292	1838	28	ph	ph	ADJ
admet-292	1838	29	scale	scale	NOUN
admet-292	1838	30	at	at	ADP
admet-292	1838	31	individual	individual	ADJ
admet-292	1838	32	points	point	NOUN
admet-292	1838	33	to	to	ADP
admet-292	1838	34	a	a	DET
admet-292	1838	35	“	"	PUNCT
admet-292	1838	36	reference	reference	NOUN
admet-292	1838	37	”	"	PUNCT
admet-292	1838	38	ionic	ionic	ADJ
admet-292	1838	39	strength	strength	NOUN
admet-292	1838	40	,	,	PUNCT
admet-292	1838	41	e.g.	e.g.	ADV
admet-292	1838	42	,	,	PUNCT
admet-292	1838	43	0.15	0.15	NUM
admet-292	1838	44	m.	m.	NOUN
admet-292	1838	45	the	the	PRON
admet-292	1838	46	higher	high	ADJ
admet-292	1838	47	the	the	DET
admet-292	1838	48	actual	actual	ADJ
admet-292	1838	49	ionic	ionic	ADJ
admet-292	1838	50	strength	strength	NOUN
admet-292	1838	51	is	be	AUX
admet-292	1838	52	above	above	ADP
admet-292	1838	53	physiological	physiological	NOUN
admet-292	1838	54	,	,	PUNCT
admet-292	1838	55	the	the	DET
admet-292	1838	56	more	more	ADV
admet-292	1838	57	tenuous	tenuous	ADJ
admet-292	1838	58	are	be	AUX
admet-292	1838	59	the	the	DET
admet-292	1838	60	stokes	stokes	PROPN
admet-292	1838	61	-	-	PUNCT
admet-292	1838	62	robinson	robinson	PROPN
admet-292	1838	63	-	-	PUNCT
admet-292	1838	64	debye	debye	ADJ
admet-292	1838	65	-	-	PUNCT
admet-292	1838	66	huckel	huckel	NOUN
admet-292	1838	67	corrections	correction	NOUN
admet-292	1838	68	for	for	ADP
admet-292	1838	69	activity	activity	NOUN
admet-292	1838	70	coefficient	coefficient	NOUN
admet-292	1838	71	changes	change	NOUN
admet-292	1838	72	.	.	PUNCT
admet-292	1839	1	about	about	ADP
admet-292	1839	2	buffers	buffer	NOUN
admet-292	1839	3	:	:	PUNCT
admet-292	1839	4	why	why	SCONJ
admet-292	1839	5	do	do	AUX
admet-292	1839	6	we	we	PRON
admet-292	1839	7	need	need	VERB
admet-292	1839	8	to	to	PART
admet-292	1839	9	use	use	VERB
admet-292	1839	10	them	they	PRON
admet-292	1839	11	at	at	ADV
admet-292	1839	12	all	all	ADV
admet-292	1839	13	?	?	PUNCT
admet-292	1840	1	two	two	NUM
admet-292	1840	2	part	part	NOUN
admet-292	1840	3	answer	answer	NOUN
admet-292	1840	4	:	:	PUNCT
admet-292	1840	5	(	(	PUNCT
admet-292	1840	6	a	a	X
admet-292	1840	7	)	)	PUNCT
admet-292	1840	8	in	in	ADP
admet-292	1840	9	very	very	ADV
admet-292	1840	10	poorly	poorly	ADV
admet-292	1840	11	buffered	buffer	VERB
admet-292	1840	12	solution	solution	NOUN
admet-292	1840	13	,	,	PUNCT
admet-292	1840	14	the	the	DET
admet-292	1840	15	tiniest	tiny	ADJ
admet-292	1840	16	addition	addition	NOUN
admet-292	1840	17	of	of	ADP
admet-292	1840	18	titrant	titrant	NOUN
admet-292	1840	19	to	to	PART
admet-292	1840	20	adjust	adjust	VERB
admet-292	1840	21	ph	ph	ADJ
admet-292	1840	22	causes	cause	NOUN
admet-292	1840	23	huge	huge	ADJ
admet-292	1840	24	changes	change	NOUN
admet-292	1840	25	in	in	ADP
admet-292	1840	26	ph	ph	NOUN
admet-292	1840	27	(	(	PUNCT
admet-292	1840	28	e.g.	e.g.	ADV
admet-292	1840	29	,	,	PUNCT
admet-292	1840	30	try	try	VERB
admet-292	1840	31	getting	get	VERB
admet-292	1840	32	lots	lot	NOUN
admet-292	1840	33	of	of	ADP
admet-292	1840	34	points	point	NOUN
admet-292	1840	35	in	in	ADP
admet-292	1840	36	the	the	DET
admet-292	1840	37	ph	ph	ADJ
admet-292	1840	38	3	3	NUM
admet-292	1840	39	–	–	SYM
admet-292	1840	40	9	9	NUM
admet-292	1840	41	region	region	NOUN
admet-292	1840	42	in	in	ADP
admet-292	1840	43	the	the	DET
admet-292	1840	44	titration	titration	NOUN
admet-292	1840	45	of	of	ADP
admet-292	1840	46	carbonate	carbonate	NOUN
admet-292	1840	47	-	-	PUNCT
admet-292	1840	48	free	free	ADJ
admet-292	1840	49	distilled	distil	VERB
admet-292	1840	50	water	water	NOUN
admet-292	1840	51	with	with	ADP
admet-292	1840	52	0.5	0.5	NUM
admet-292	1840	53	m	m	NOUN
admet-292	1840	54	naoh	naoh	NOUN
admet-292	1840	55	!	!	PUNCT
admet-292	1841	1	–	–	PUNCT
admet-292	1841	2	not	not	PART
admet-292	1841	3	so	so	ADV
admet-292	1841	4	easy	easy	ADJ
admet-292	1841	5	)	)	PUNCT
admet-292	1841	6	.	.	PUNCT
admet-292	1842	1	also	also	ADV
admet-292	1842	2	,	,	PUNCT
admet-292	1842	3	if	if	SCONJ
admet-292	1842	4	the	the	DET
admet-292	1842	5	ionic	ionic	ADJ
admet-292	1842	6	strength	strength	NOUN
admet-292	1842	7	is	be	AUX
admet-292	1842	8	very	very	ADV
admet-292	1842	9	low	low	ADJ
admet-292	1842	10	in	in	ADP
admet-292	1842	11	the	the	DET
admet-292	1842	12	poorly	poorly	ADV
admet-292	1842	13	buffered	buffer	VERB
admet-292	1842	14	solution	solution	NOUN
admet-292	1842	15	,	,	PUNCT
admet-292	1842	16	then	then	ADV
admet-292	1842	17	the	the	DET
admet-292	1842	18	ph	ph	ADJ
admet-292	1842	19	electrode	electrode	NOUN
admet-292	1842	20	experiences	experience	NOUN
admet-292	1842	21	“	"	PUNCT
admet-292	1842	22	junction	junction	NOUN
admet-292	1842	23	potential	potential	ADJ
admet-292	1842	24	”	"	PUNCT
admet-292	1842	25	shifts	shift	NOUN
admet-292	1842	26	,	,	PUNCT
admet-292	1842	27	leading	lead	VERB
admet-292	1842	28	to	to	ADP
admet-292	1842	29	uncertainty	uncertainty	NOUN
admet-292	1842	30	in	in	ADP
admet-292	1842	31	ph	ph	ADJ
admet-292	1842	32	measurement	measurement	NOUN
admet-292	1842	33	.	.	PUNCT
admet-292	1843	1	the	the	DET
admet-292	1843	2	addition	addition	NOUN
admet-292	1843	3	of	of	ADP
admet-292	1843	4	buffer	buffer	NOUN
admet-292	1843	5	in	in	ADP
admet-292	1843	6	that	that	DET
admet-292	1843	7	steep	steep	ADJ
admet-292	1843	8	slope	slope	NOUN
admet-292	1843	9	region	region	NOUN
admet-292	1843	10	allows	allow	VERB
admet-292	1843	11	controlled	control	VERB
admet-292	1843	12	additions	addition	NOUN
admet-292	1843	13	of	of	ADP
admet-292	1843	14	ph	ph	ADJ
admet-292	1843	15	modifier	modifier	NOUN
admet-292	1843	16	(	(	PUNCT
admet-292	1843	17	i.e.	i.e.	X
admet-292	1843	18	,	,	PUNCT
admet-292	1843	19	“	"	PUNCT
admet-292	1843	20	titrant	titrant	NOUN
admet-292	1843	21	”	"	PUNCT
admet-292	1843	22	)	)	PUNCT
admet-292	1843	23	.	.	PUNCT
admet-292	1844	1	how	how	SCONJ
admet-292	1844	2	much	much	ADJ
admet-292	1844	3	buffer	buffer	NOUN
admet-292	1844	4	?	?	PUNCT
admet-292	1845	1	–	–	PUNCT
admet-292	1845	2	no	no	ADV
admet-292	1845	3	more	more	ADJ
admet-292	1845	4	than	than	ADP
admet-292	1845	5	enough	enough	ADJ
admet-292	1845	6	to	to	PART
admet-292	1845	7	do	do	VERB
admet-292	1845	8	the	the	DET
admet-292	1845	9	job	job	NOUN
admet-292	1845	10	.	.	PUNCT
admet-292	1846	1	that	that	PRON
admet-292	1846	2	depends	depend	VERB
admet-292	1846	3	on	on	ADP
admet-292	1846	4	the	the	DET
admet-292	1846	5	quality	quality	NOUN
admet-292	1846	6	and	and	CCONJ
admet-292	1846	7	resolution	resolution	NOUN
admet-292	1846	8	of	of	ADP
admet-292	1846	9	the	the	DET
admet-292	1846	10	liquid	liquid	ADJ
admet-292	1846	11	dispensing	dispensing	NOUN
admet-292	1846	12	devise	devise	NOUN
admet-292	1846	13	.	.	PUNCT
admet-292	1847	1	if	if	SCONJ
admet-292	1847	2	i	i	PRON
admet-292	1847	3	recall	recall	VERB
admet-292	1847	4	correctly	correctly	ADV
admet-292	1847	5	,	,	PUNCT
admet-292	1847	6	the	the	DET
admet-292	1847	7	pion	pion	NOUN
admet-292	1847	8	dispensers	dispenser	NOUN
admet-292	1847	9	can	can	AUX
admet-292	1847	10	added	add	VERB
admet-292	1847	11	30	30	NUM
admet-292	1847	12	nl	nl	NOUN
admet-292	1847	13	minimum	minimum	ADJ
admet-292	1847	14	volumes	volume	NOUN
admet-292	1847	15	.	.	PUNCT
admet-292	1848	1	my	my	PRON
admet-292	1848	2	guess	guess	NOUN
admet-292	1848	3	is	be	AUX
admet-292	1848	4	that	that	SCONJ
admet-292	1848	5	in	in	ADP
admet-292	1848	6	most	most	ADJ
admet-292	1848	7	cases	case	NOUN
admet-292	1848	8	,	,	PUNCT
admet-292	1848	9	5	5	NUM
admet-292	1848	10	–	–	SYM
admet-292	1848	11	10	10	NUM
admet-292	1848	12	mm	mm	NOUN
admet-292	1848	13	buffer	buffer	NOUN
admet-292	1848	14	is	be	AUX
admet-292	1848	15	enough	enough	ADJ
admet-292	1848	16	.	.	PUNCT
admet-292	1849	1	do	do	AUX
admet-292	1849	2	n’t	not	PART
admet-292	1849	3	forget	forget	VERB
admet-292	1849	4	,	,	PUNCT
admet-292	1849	5	the	the	DET
admet-292	1849	6	drug	drug	NOUN
admet-292	1849	7	itself	itself	PRON
admet-292	1849	8	can	can	AUX
admet-292	1849	9	serve	serve	VERB
admet-292	1849	10	as	as	ADP
admet-292	1849	11	a	a	DET
admet-292	1849	12	buffer	buffer	NOUN
admet-292	1849	13	.	.	PUNCT
admet-292	1850	1	(	(	PUNCT
admet-292	1850	2	b	b	X
admet-292	1850	3	)	)	PUNCT
admet-292	1850	4	if	if	SCONJ
admet-292	1850	5	the	the	DET
admet-292	1850	6	solution	solution	NOUN
admet-292	1850	7	is	be	AUX
admet-292	1850	8	not	not	PART
admet-292	1850	9	adequately	adequately	ADV
admet-292	1850	10	buffered	buffer	VERB
admet-292	1850	11	,	,	PUNCT
admet-292	1850	12	then	then	ADV
admet-292	1850	13	reading	read	VERB
admet-292	1850	14	of	of	ADP
admet-292	1850	15	ph	ph	NOUN
admet-292	1850	16	becomes	become	VERB
admet-292	1850	17	uncertain	uncertain	ADJ
admet-292	1850	18	,	,	PUNCT
admet-292	1850	19	and	and	CCONJ
admet-292	1850	20	also	also	ADV
admet-292	1850	21	,	,	PUNCT
admet-292	1850	22	trace	trace	NOUN
admet-292	1850	23	protogenic	protogenic	ADJ
admet-292	1850	24	impurities	impurity	NOUN
admet-292	1850	25	can	can	AUX
admet-292	1850	26	be	be	AUX
admet-292	1850	27	problematic	problematic	ADJ
admet-292	1850	28	(	(	PUNCT
admet-292	1850	29	like	like	INTJ
admet-292	1850	30	ambient	ambient	ADJ
admet-292	1850	31	co2	co2	NOUN
admet-292	1850	32	:	:	PUNCT
admet-292	1850	33	it	it	PRON
admet-292	1850	34	can	can	AUX
admet-292	1850	35	cause	cause	VERB
admet-292	1850	36	big	big	ADJ
admet-292	1850	37	ph	ph	ADJ
admet-292	1850	38	shifts	shift	NOUN
admet-292	1850	39	,	,	PUNCT
admet-292	1850	40	leading	lead	VERB
admet-292	1850	41	to	to	ADP
admet-292	1850	42	uncertainty	uncertainty	NOUN
admet-292	1850	43	in	in	ADP
admet-292	1850	44	the	the	DET
admet-292	1850	45	solubility	solubility	NOUN
admet-292	1850	46	reading	read	VERB
admet-292	1850	47	for	for	ADP
admet-292	1850	48	lowsoluble	lowsoluble	ADJ
admet-292	1850	49	bases	basis	NOUN
admet-292	1850	50	with	with	ADP
admet-292	1850	51	pka	pka	PROPN
admet-292	1850	52	>	>	X
admet-292	1850	53	8)	8)	NUM
admet-292	1850	54	.	.	PUNCT
admet-292	1851	1	you	you	PRON
admet-292	1851	2	do	do	AUX
admet-292	1851	3	n’t	not	PART
admet-292	1851	4	need	need	VERB
admet-292	1851	5	any	any	DET
admet-292	1851	6	extra	extra	ADJ
admet-292	1851	7	buffering	buffering	NOUN
admet-292	1851	8	for	for	ADP
admet-292	1851	9	ph<2	ph<2	NOUN
admet-292	1851	10	or	or	CCONJ
admet-292	1851	11	ph>11	ph>11	ADV
admet-292	1851	12	;	;	PUNCT
admet-292	1851	13	water	water	NOUN
admet-292	1851	14	does	do	VERB
admet-292	1851	15	a	a	DET
admet-292	1851	16	good	good	ADJ
admet-292	1851	17	job	job	NOUN
admet-292	1851	18	there	there	ADV
admet-292	1851	19	.	.	PUNCT
admet-292	1852	1	to	to	PART
admet-292	1852	2	sum	sum	VERB
admet-292	1852	3	up	up	ADP
admet-292	1852	4	:	:	PUNCT
admet-292	1852	5	use	use	VERB
admet-292	1852	6	“	"	PUNCT
admet-292	1852	7	just	just	ADV
admet-292	1852	8	enough	enough	ADJ
admet-292	1852	9	”	"	PUNCT
admet-292	1852	10	buffer	buffer	NOUN
admet-292	1852	11	only	only	ADV
admet-292	1852	12	in	in	ADP
admet-292	1852	13	the	the	DET
admet-292	1852	14	regions	region	NOUN
admet-292	1852	15	of	of	ADP
admet-292	1852	16	ph	ph	NOUN
admet-292	1852	17	where	where	SCONJ
admet-292	1852	18	buffering	buffering	NOUN
admet-292	1852	19	is	be	AUX
admet-292	1852	20	needed	need	VERB
admet-292	1852	21	.	.	PUNCT
admet-292	1853	1	of	of	ADP
admet-292	1853	2	course	course	NOUN
admet-292	1853	3	,	,	PUNCT
admet-292	1853	4	that	that	SCONJ
admet-292	1853	5	all	all	PRON
admet-292	1853	6	depends	depend	VERB
admet-292	1853	7	on	on	ADP
admet-292	1853	8	the	the	DET
admet-292	1853	9	compound	compound	NOUN
admet-292	1853	10	studied	study	VERB
admet-292	1853	11	.	.	PUNCT
admet-292	1854	1	when	when	SCONJ
admet-292	1854	2	the	the	DET
admet-292	1854	3	contributions	contribution	NOUN
admet-292	1854	4	from	from	ADP
admet-292	1854	5	the	the	DET
admet-292	1854	6	buffer(s	buffer(s	NOUN
admet-292	1854	7	)	)	PUNCT
admet-292	1854	8	added	add	VERB
admet-292	1854	9	are	be	AUX
admet-292	1854	10	assessed	assess	VERB
admet-292	1854	11	,	,	PUNCT
admet-292	1854	12	if	if	SCONJ
admet-292	1854	13	the	the	DET
admet-292	1854	14	ionic	ionic	ADJ
admet-292	1854	15	strength	strength	NOUN
admet-292	1854	16	is	be	AUX
admet-292	1854	17	significantly	significantly	ADV
admet-292	1854	18	less	less	ADJ
admet-292	1854	19	than	than	ADP
admet-292	1854	20	0.15	0.15	NUM
admet-292	1854	21	m	m	NOUN
admet-292	1854	22	,	,	PUNCT
admet-292	1854	23	then	then	ADV
admet-292	1854	24	i	i	PRON
admet-292	1854	25	would	would	AUX
admet-292	1854	26	added	add	VERB
admet-292	1854	27	some	some	DET
admet-292	1854	28	extra	extra	ADJ
admet-292	1854	29	nacl	nacl	NOUN
admet-292	1854	30	to	to	PART
admet-292	1854	31	reach	reach	VERB
admet-292	1854	32	0.15	0.15	NUM
admet-292	1854	33	m	m	NOUN
admet-292	1854	34	total	total	ADJ
admet-292	1854	35	ionic	ionic	ADJ
admet-292	1854	36	strength	strength	NOUN
admet-292	1854	37	.	.	PUNCT
admet-292	1855	1	many	many	ADJ
admet-292	1855	2	people	people	NOUN
admet-292	1855	3	would	would	AUX
admet-292	1855	4	be	be	AUX
admet-292	1855	5	surprised	surprise	VERB
admet-292	1855	6	how	how	SCONJ
admet-292	1855	7	much	much	ADJ
admet-292	1855	8	time	time	NOUN
admet-292	1855	9	i	i	PRON
admet-292	1855	10	spend	spend	VERB
admet-292	1855	11	planning	plan	VERB
admet-292	1855	12	a	a	DET
admet-292	1855	13	measurement	measurement	NOUN
admet-292	1855	14	for	for	ADP
admet-292	1855	15	a	a	DET
admet-292	1855	16	new	new	ADJ
admet-292	1855	17	drug	drug	NOUN
admet-292	1855	18	substance	substance	NOUN
admet-292	1855	19	.	.	PUNCT
admet-292	1856	1	i	i	PRON
admet-292	1856	2	am	be	AUX
admet-292	1856	3	not	not	PART
admet-292	1856	4	in	in	ADP
admet-292	1856	5	favor	favor	NOUN
admet-292	1856	6	of	of	ADP
admet-292	1856	7	“	"	PUNCT
admet-292	1856	8	canned	canned	ADJ
admet-292	1856	9	formula	formula	NOUN
admet-292	1856	10	”	"	PUNCT
admet-292	1856	11	use	use	NOUN
admet-292	1856	12	of	of	ADP
admet-292	1856	13	buffers	buffer	NOUN
admet-292	1856	14	.	.	PUNCT
admet-292	1857	1	some	some	DET
admet-292	1857	2	labs	lab	NOUN
admet-292	1857	3	are	be	AUX
admet-292	1857	4	fond	fond	ADJ
admet-292	1857	5	of	of	ADP
admet-292	1857	6	using	use	VERB
admet-292	1857	7	the	the	DET
admet-292	1857	8	mcilvaine	mcilvaine	ADJ
admet-292	1857	9	buffer	buffer	NOUN
admet-292	1857	10	,	,	PUNCT
admet-292	1857	11	which	which	PRON
admet-292	1857	12	has	have	VERB
admet-292	1857	13	high	high	ADJ
admet-292	1857	14	citrate	citrate	NOUN
admet-292	1857	15	and	and	CCONJ
admet-292	1857	16	phosphate	phosphate	ADJ
admet-292	1857	17	concentrations	concentration	NOUN
admet-292	1857	18	.	.	PUNCT
admet-292	1858	1	it	it	PRON
admet-292	1858	2	just	just	ADV
admet-292	1858	3	makes	make	VERB
admet-292	1858	4	the	the	DET
admet-292	1858	5	data	datum	NOUN
admet-292	1858	6	analysis	analysis	NOUN
admet-292	1858	7	that	that	SCONJ
admet-292	1858	8	much	much	ADV
admet-292	1858	9	more	more	ADV
admet-292	1858	10	complicated	complicated	ADJ
admet-292	1858	11	.	.	PUNCT
admet-292	1859	1	“	"	PUNCT
admet-292	1859	2	theory	theory	NOUN
admet-292	1859	3	guides	guide	NOUN
admet-292	1859	4	,	,	PUNCT
admet-292	1859	5	experiment	experiment	NOUN
admet-292	1859	6	decides	decide	VERB
admet-292	1859	7	,	,	PUNCT
admet-292	1859	8	”	"	PUNCT
admet-292	1859	9	or	or	CCONJ
admet-292	1859	10	“	"	PUNCT
admet-292	1859	11	first	first	ADV
admet-292	1859	12	think	think	VERB
admet-292	1859	13	,	,	PUNCT
admet-292	1859	14	then	then	ADV
admet-292	1859	15	measure	measure	VERB
admet-292	1859	16	.	.	PUNCT
admet-292	1859	17	”	"	PUNCT
admet-292	1860	1	etc	etc	X
admet-292	1860	2	.	.	X
admet-292	1860	3	,	,	PUNCT
admet-292	1860	4	etc	etc	X
admet-292	1860	5	.	.	X
admet-292	1861	1	as	as	ADP
admet-292	1861	2	a	a	DET
admet-292	1861	3	final	final	ADJ
admet-292	1861	4	thought	thought	NOUN
admet-292	1861	5	,	,	PUNCT
admet-292	1861	6	try	try	VERB
admet-292	1861	7	to	to	PART
admet-292	1861	8	avoid	avoid	VERB
admet-292	1861	9	buffers	buffer	NOUN
admet-292	1861	10	that	that	PRON
admet-292	1861	11	have	have	VERB
admet-292	1861	12	high	high	ADJ
admet-292	1861	13	uv	uv	NOUN
admet-292	1861	14	absorption	absorption	NOUN
admet-292	1861	15	,	,	PUNCT
admet-292	1861	16	if	if	SCONJ
admet-292	1861	17	you	you	PRON
admet-292	1861	18	are	be	AUX
admet-292	1861	19	doing	do	VERB
admet-292	1861	20	uv	uv	NOUN
admet-292	1861	21	-	-	PUNCT
admet-292	1861	22	vis	vis	X
admet-292	1861	23	or	or	CCONJ
admet-292	1861	24	hplc	hplc	NOUN
admet-292	1861	25	analysis	analysis	NOUN
admet-292	1861	26	.	.	PUNCT
admet-292	1862	1	some	some	DET
admet-292	1862	2	buffers	buffer	NOUN
admet-292	1862	3	(	(	PUNCT
admet-292	1862	4	like	like	ADP
admet-292	1862	5	phosphate	phosphate	NOUN
admet-292	1862	6	)	)	PUNCT
admet-292	1862	7	gum	gum	NOUN
admet-292	1862	8	up	up	ADP
admet-292	1862	9	lc	lc	PROPN
admet-292	1862	10	-	-	PUNCT
admet-292	1862	11	ms	ms	PROPN
admet-292	1862	12	-	-	PUNCT
admet-292	1862	13	ms	ms	NOUN
admet-292	1862	14	systems	system	NOUN
admet-292	1862	15	.	.	PUNCT
admet-292	1863	1	q	q	X
admet-292	1863	2	:	:	PUNCT
admet-292	1863	3	what	what	DET
admet-292	1863	4	criteria	criterion	NOUN
admet-292	1863	5	did	do	AUX
admet-292	1863	6	you	you	PRON
admet-292	1863	7	use	use	VERB
admet-292	1863	8	in	in	ADP
admet-292	1863	9	order	order	NOUN
admet-292	1863	10	to	to	PART
admet-292	1863	11	make	make	VERB
admet-292	1863	12	the	the	DET
admet-292	1863	13	conclusions	conclusion	NOUN
admet-292	1863	14	at	at	ADP
admet-292	1863	15	the	the	DET
admet-292	1863	16	end	end	NOUN
admet-292	1863	17	of	of	ADP
admet-292	1863	18	the	the	DET
admet-292	1863	19	filter	filter	NOUN
admet-292	1863	20	-	-	PUNCT
admet-292	1863	21	selection	selection	NOUN
admet-292	1863	22	poster	poster	NOUN
admet-292	1863	23	?	?	PUNCT
admet-292	1864	1	my	my	PRON
admet-292	1864	2	working	working	NOUN
admet-292	1864	3	hypothesis	hypothesis	NOUN
admet-292	1864	4	is	be	AUX
admet-292	1864	5	that	that	SCONJ
admet-292	1864	6	if	if	SCONJ
admet-292	1864	7	the	the	DET
admet-292	1864	8	value	value	NOUN
admet-292	1864	9	of	of	ADP
admet-292	1864	10	solubility	solubility	NOUN
admet-292	1864	11	is	be	AUX
admet-292	1864	12	unexpectedly	unexpectedly	ADV
admet-292	1864	13	low	low	ADJ
admet-292	1864	14	,	,	PUNCT
admet-292	1864	15	then	then	ADV
admet-292	1864	16	filter	filter	NOUN
admet-292	1864	17	adsorption	adsorption	NOUN
admet-292	1864	18	of	of	ADP
admet-292	1864	19	the	the	DET
admet-292	1864	20	sample	sample	NOUN
admet-292	1864	21	may	may	AUX
admet-292	1864	22	have	have	AUX
admet-292	1864	23	been	be	AUX
admet-292	1864	24	a	a	DET
admet-292	1864	25	problem	problem	NOUN
admet-292	1864	26	.	.	PUNCT
admet-292	1865	1	this	this	PRON
admet-292	1865	2	is	be	AUX
admet-292	1865	3	a	a	DET
admet-292	1865	4	common	common	ADJ
admet-292	1865	5	assumption	assumption	NOUN
admet-292	1865	6	.	.	PUNCT
admet-292	1866	1	a2	a2	PROPN
admet-292	1866	2	:	:	PUNCT
admet-292	1867	1	yes	yes	INTJ
admet-292	1867	2	,	,	PUNCT
admet-292	1867	3	this	this	DET
admet-292	1867	4	hypothesis	hypothesis	NOUN
admet-292	1867	5	is	be	AUX
admet-292	1867	6	correct	correct	ADJ
admet-292	1867	7	.	.	PUNCT
admet-292	1868	1	those	those	DET
admet-292	1868	2	conclusions	conclusion	NOUN
admet-292	1868	3	were	be	AUX
admet-292	1868	4	rather	rather	ADV
admet-292	1868	5	suggestions	suggestion	NOUN
admet-292	1868	6	.	.	PUNCT
admet-292	1869	1	it	it	PRON
admet-292	1869	2	is	be	AUX
admet-292	1869	3	better	well	ADJ
admet-292	1869	4	to	to	PART
admet-292	1869	5	avoid	avoid	VERB
admet-292	1869	6	the	the	DET
admet-292	1869	7	filtration	filtration	NOUN
admet-292	1869	8	,	,	PUNCT
admet-292	1869	9	but	but	CCONJ
admet-292	1869	10	if	if	SCONJ
admet-292	1869	11	not	not	PART
admet-292	1869	12	possible	possible	ADJ
admet-292	1869	13	,	,	PUNCT
admet-292	1869	14	we	we	PRON
admet-292	1869	15	have	have	VERB
admet-292	1869	16	to	to	PART
admet-292	1869	17	select	select	VERB
admet-292	1869	18	the	the	DET
admet-292	1869	19	right	right	ADJ
admet-292	1869	20	filter	filter	NOUN
admet-292	1869	21	(	(	PUNCT
admet-292	1869	22	hydrophobic	hydrophobic	NOUN
admet-292	1869	23	for	for	ADP
admet-292	1869	24	ionized	ionized	ADJ
admet-292	1869	25	polar	polar	ADJ
admet-292	1869	26	species	specie	NOUN
admet-292	1869	27	and	and	CCONJ
admet-292	1869	28	hydrophilic	hydrophilic	NOUN
admet-292	1869	29	for	for	ADP
admet-292	1869	30	unionized	unionized	ADJ
admet-292	1869	31	lipophilic	lipophilic	ADJ
admet-292	1869	32	species	specie	NOUN
admet-292	1869	33	)	)	PUNCT
admet-292	1869	34	;	;	PUNCT
admet-292	1869	35	with	with	ADP
admet-292	1869	36	discarding	discard	VERB
admet-292	1869	37	the	the	DET
admet-292	1869	38	first	first	ADJ
admet-292	1869	39	few	few	ADJ
admet-292	1869	40	portions	portion	NOUN
admet-292	1869	41	of	of	ADP
admet-292	1869	42	filtration	filtration	NOUN
admet-292	1869	43	,	,	PUNCT
admet-292	1869	44	etc	etc	X
admet-292	1869	45	.	.	X
admet-292	1869	46	a1	a1	NOUN
admet-292	1869	47	:	:	PUNCT
admet-292	1869	48	however	however	ADV
admet-292	1869	49	,	,	PUNCT
admet-292	1869	50	can	can	AUX
admet-292	1869	51	there	there	PRON
admet-292	1869	52	be	be	AUX
admet-292	1869	53	a	a	DET
admet-292	1869	54	case	case	NOUN
admet-292	1869	55	when	when	SCONJ
admet-292	1869	56	high	high	ADJ
admet-292	1869	57	solubility	solubility	NOUN
admet-292	1869	58	is	be	AUX
admet-292	1869	59	not	not	PART
admet-292	1869	60	a	a	DET
admet-292	1869	61	good	good	ADJ
admet-292	1869	62	result	result	NOUN
admet-292	1869	63	?	?	PUNCT
admet-292	1870	1	if	if	SCONJ
admet-292	1870	2	the	the	DET
admet-292	1870	3	solubility	solubility	NOUN
admet-292	1870	4	assay	assay	AUX
admet-292	1870	5	produced	produce	VERB
admet-292	1870	6	some	some	DET
admet-292	1870	7	(	(	PUNCT
admet-292	1870	8	not	not	PART
admet-292	1870	9	all	all	PRON
admet-292	1870	10	)	)	PUNCT
admet-292	1870	11	very	very	ADV
admet-292	1870	12	tiny	tiny	ADJ
admet-292	1870	13	particles	particle	NOUN
admet-292	1870	14	and	and	CCONJ
admet-292	1870	15	if	if	SCONJ
admet-292	1870	16	some	some	PRON
admet-292	1870	17	were	be	AUX
admet-292	1870	18	able	able	ADJ
admet-292	1870	19	to	to	PART
admet-292	1870	20	pass	pass	VERB
admet-292	1870	21	through	through	ADP
admet-292	1870	22	the	the	DET
admet-292	1870	23	filter	filter	NOUN
admet-292	1870	24	pores	pore	NOUN
admet-292	1870	25	,	,	PUNCT
admet-292	1870	26	then	then	ADV
admet-292	1870	27	the	the	DET
admet-292	1870	28	measured	measured	ADJ
admet-292	1870	29	solubility	solubility	NOUN
admet-292	1870	30	would	would	AUX
admet-292	1870	31	be	be	AUX
admet-292	1870	32	unexpectedly	unexpectedly	ADV
admet-292	1870	33	high	high	ADJ
admet-292	1870	34	.	.	PUNCT
admet-292	1871	1	a2	a2	PROPN
admet-292	1871	2	:	:	PUNCT
admet-292	1871	3	it	it	PRON
admet-292	1871	4	may	may	AUX
admet-292	1871	5	happen	happen	VERB
admet-292	1871	6	.	.	PUNCT
admet-292	1872	1	we	we	PRON
admet-292	1872	2	think	think	VERB
admet-292	1872	3	that	that	SCONJ
admet-292	1872	4	when	when	SCONJ
admet-292	1872	5	we	we	PRON
admet-292	1872	6	filter	filter	VERB
admet-292	1872	7	a	a	DET
admet-292	1872	8	high	high	ADJ
admet-292	1872	9	concentration	concentration	NOUN
admet-292	1872	10	solution	solution	NOUN
admet-292	1872	11	the	the	DET
admet-292	1872	12	filter	filter	NOUN
admet-292	1872	13	can	can	AUX
admet-292	1872	14	be	be	AUX
admet-292	1872	15	saturated	saturate	VERB
admet-292	1872	16	more	more	ADV
admet-292	1872	17	quickly	quickly	ADV
admet-292	1872	18	and	and	CCONJ
admet-292	1872	19	the	the	DET
admet-292	1872	20	error	error	NOUN
admet-292	1872	21	caused	cause	VERB
admet-292	1872	22	by	by	ADP
admet-292	1872	23	the	the	DET
admet-292	1872	24	adsorption	adsorption	NOUN
admet-292	1872	25	is	be	AUX
admet-292	1872	26	relative	relative	ADV
admet-292	1872	27	less	less	ADJ
admet-292	1872	28	.	.	PUNCT
admet-292	1873	1	a1	a1	NOUN
admet-292	1873	2	:	:	PUNCT
admet-292	1873	3	did	do	AUX
admet-292	1873	4	you	you	PRON
admet-292	1873	5	have	have	VERB
admet-292	1873	6	any	any	DET
admet-292	1873	7	suggestions	suggestion	NOUN
admet-292	1873	8	about	about	ADP
admet-292	1873	9	how	how	SCONJ
admet-292	1873	10	fast	fast	ADV
admet-292	1873	11	(	(	PUNCT
admet-292	1873	12	or	or	CCONJ
admet-292	1873	13	slow	slow	ADJ
admet-292	1873	14	)	)	PUNCT
admet-292	1873	15	to	to	PART
admet-292	1873	16	push	push	VERB
admet-292	1873	17	the	the	DET
admet-292	1873	18	syringe	syringe	NOUN
admet-292	1873	19	plunger	plunger	NOUN
admet-292	1873	20	through	through	ADP
admet-292	1873	21	the	the	DET
admet-292	1873	22	filter	filter	NOUN
admet-292	1873	23	disks	disk	NOUN
admet-292	1873	24	?	?	PUNCT
admet-292	1874	1	a2	a2	PROPN
admet-292	1874	2	:	:	PUNCT
admet-292	1874	3	good	good	ADJ
admet-292	1874	4	question	question	NOUN
admet-292	1874	5	.	.	PUNCT
admet-292	1875	1	we	we	PRON
admet-292	1875	2	filtered	filter	VERB
admet-292	1875	3	300	300	NUM
admet-292	1875	4	μl	μl	ADP
admet-292	1875	5	and	and	CCONJ
admet-292	1875	6	600	600	NUM
admet-292	1875	7	μl	μl	ADP
admet-292	1875	8	portions	portion	NOUN
admet-292	1875	9	,	,	PUNCT
admet-292	1875	10	generally	generally	ADV
admet-292	1875	11	quite	quite	ADV
admet-292	1875	12	slowly	slowly	ADV
admet-292	1875	13	.	.	PUNCT
admet-292	1876	1	©	©	PROPN
admet-292	1876	2	2016	2016	NUM
admet-292	1876	3	by	by	ADP
admet-292	1876	4	the	the	DET
admet-292	1876	5	authors	author	NOUN
admet-292	1876	6	;	;	PUNCT
admet-292	1876	7	licensee	licensee	PROPN
admet-292	1876	8	iapc	iapc	PROPN
admet-292	1876	9	,	,	PUNCT
admet-292	1876	10	zagreb	zagreb	PROPN
admet-292	1876	11	,	,	PUNCT
admet-292	1876	12	croatia	croatia	PROPN
admet-292	1876	13	.	.	PUNCT
admet-292	1877	1	this	this	DET
admet-292	1877	2	article	article	NOUN
admet-292	1877	3	is	be	AUX
admet-292	1877	4	an	an	DET
admet-292	1877	5	open	open	ADJ
admet-292	1877	6	-	-	PUNCT
admet-292	1877	7	access	access	NOUN
admet-292	1877	8	article	article	NOUN
admet-292	1877	9	distributed	distribute	VERB
admet-292	1877	10	under	under	ADP
admet-292	1877	11	the	the	DET
admet-292	1877	12	terms	term	NOUN
admet-292	1877	13	and	and	CCONJ
admet-292	1877	14	conditions	condition	NOUN
admet-292	1877	15	of	of	ADP
admet-292	1877	16	the	the	DET
admet-292	1877	17	creative	creative	ADJ
admet-292	1877	18	commons	common	NOUN
admet-292	1877	19	attribution	attribution	NOUN
admet-292	1877	20	license	license	NOUN
admet-292	1877	21	(	(	PUNCT
admet-292	1877	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-292	1877	23	)	)	PUNCT
admet-292	1877	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN