id	sid	tid	token	lemma	pos
admet-2961	1	1	elucidating	elucidate	VERB
admet-2961	1	2	cyp2d6	cyp2d6	NOUN
admet-2961	1	3	-	-	PUNCT
admet-2961	1	4	driven	drive	VERB
admet-2961	1	5	metabolism	metabolism	NOUN
admet-2961	1	6	and	and	CCONJ
admet-2961	1	7	hepatotoxic	hepatotoxic	ADJ
admet-2961	1	8	bioactivation	bioactivation	NOUN
admet-2961	1	9	of	of	ADP
admet-2961	1	10	metoprolol	metoprolol	PROPN
admet-2961	1	11	in	in	ADP
admet-2961	1	12	plateable	plateable	ADJ
admet-2961	1	13	human	human	ADJ
admet-2961	1	14	and	and	CCONJ
admet-2961	1	15	animal	animal	NOUN
admet-2961	1	16	hepatocytes	hepatocyte	NOUN
admet-2961	1	17	doi	doi	NOUN
admet-2961	1	18	:	:	PUNCT
admet-2961	1	19	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	ADJ
admet-2961	1	20	1	1	NUM
admet-2961	1	21	admet	admet	X
admet-2961	1	22	&	&	CCONJ
admet-2961	1	23	dmpk	dmpk	PROPN
admet-2961	1	24	13(5	13(5	NUM
admet-2961	1	25	)	)	PUNCT
admet-2961	1	26	(	(	PUNCT
admet-2961	1	27	2025	2025	NUM
admet-2961	1	28	)	)	PUNCT
admet-2961	1	29	2961	2961	NUM
admet-2961	1	30	;	;	PUNCT
admet-2961	1	31	doi	doi	NOUN
admet-2961	1	32	:	:	PUNCT
admet-2961	1	33	https://doi.org/10.5599/admet.2961	https://doi.org/10.5599/admet.2961	PROPN
admet-2961	1	34	open	open	ADJ
admet-2961	1	35	access	access	NOUN
admet-2961	1	36	:	:	PUNCT
admet-2961	1	37	issn	issn	PROPN
admet-2961	1	38	:	:	PUNCT
admet-2961	1	39	1848	1848	NUM
admet-2961	1	40	-	-	SYM
admet-2961	1	41	7718	7718	NUM
admet-2961	1	42	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	PROPN
admet-2961	1	43	original	original	ADJ
admet-2961	1	44	scientific	scientific	ADJ
admet-2961	1	45	paper	paper	NOUN
admet-2961	1	46	elucidating	elucidate	VERB
admet-2961	1	47	cyp2d6	cyp2d6	NOUN
admet-2961	1	48	-	-	PUNCT
admet-2961	1	49	driven	drive	VERB
admet-2961	1	50	metabolism	metabolism	NOUN
admet-2961	1	51	and	and	CCONJ
admet-2961	1	52	hepatotoxic	hepatotoxic	ADJ
admet-2961	1	53	bioactivation	bioactivation	NOUN
admet-2961	1	54	of	of	ADP
admet-2961	1	55	metoprolol	metoprolol	PROPN
admet-2961	1	56	in	in	ADP
admet-2961	1	57	plateable	plateable	ADJ
admet-2961	1	58	human	human	ADJ
admet-2961	1	59	and	and	CCONJ
admet-2961	1	60	animal	animal	NOUN
admet-2961	1	61	hepatocytes	hepatocyte	NOUN
admet-2961	1	62	jiang	jiang	PROPN
admet-2961	1	63	pu	pu	PROPN
admet-2961	1	64	,	,	PUNCT
admet-2961	1	65	mei	mei	PROPN
admet-2961	1	66	yang	yang	PROPN
admet-2961	1	67	,	,	PUNCT
admet-2961	1	68	min	min	PROPN
admet-2961	1	69	zhang	zhang	PROPN
admet-2961	1	70	,	,	PUNCT
admet-2961	1	71	ruiqi	ruiqi	PROPN
admet-2961	1	72	gao	gao	PROPN
admet-2961	1	73	,	,	PUNCT
admet-2961	1	74	yue	yue	PROPN
admet-2961	1	75	xiao	xiao	PROPN
admet-2961	1	76	,	,	PUNCT
admet-2961	1	77	lingyu	lingyu	PROPN
admet-2961	1	78	liu	liu	PROPN
admet-2961	1	79	,	,	PUNCT
admet-2961	1	80	chuanjing	chuanjing	PROPN
admet-2961	1	81	zhang	zhang	PROPN
admet-2961	1	82	,	,	PUNCT
admet-2961	1	83	wennuo	wennuo	PROPN
admet-2961	1	84	xu	xu	PROPN
admet-2961	1	85	,	,	PUNCT
admet-2961	1	86	kaifang	kaifang	PROPN
admet-2961	1	87	li	li	PROPN
admet-2961	1	88	and	and	CCONJ
admet-2961	1	89	wanyong	wanyong	PROPN
admet-2961	1	90	feng	feng	PROPN
admet-2961	1	91	*	*	PUNCT
admet-2961	1	92	bioduro	bioduro	PROPN
admet-2961	1	93	biologics	biologics	PROPN
admet-2961	1	94	co.	co.	PROPN
admet-2961	1	95	,	,	PUNCT
admet-2961	1	96	ltd	ltd	PROPN
admet-2961	1	97	.	.	PROPN
admet-2961	1	98	,	,	PUNCT
admet-2961	1	99	shanghai	shanghai	PROPN
admet-2961	1	100	,	,	PUNCT
admet-2961	1	101	china	china	PROPN
admet-2961	1	102	*	*	PUNCT
admet-2961	1	103	corresponding	correspond	VERB
admet-2961	1	104	author	author	NOUN
admet-2961	1	105	:	:	PUNCT
admet-2961	1	106	e	e	NOUN
admet-2961	1	107	-	-	NOUN
admet-2961	1	108	mail	mail	NOUN
admet-2961	1	109	:	:	PUNCT
admet-2961	1	110	wanyong.feng@bioduro.com	wanyong.feng@bioduro.com	X
admet-2961	1	111	;	;	PUNCT
admet-2961	1	112	tel	tel	PROPN
admet-2961	1	113	.	.	PUNCT
admet-2961	1	114	:	:	PUNCT
admet-2961	2	1	+86	+86	PROPN
admet-2961	2	2	-	-	PUNCT
admet-2961	2	3	021	021	NUM
admet-2961	2	4	-	-	PUNCT
admet-2961	2	5	31751005	31751005	NUM
admet-2961	2	6	received	receive	VERB
admet-2961	2	7	:	:	PUNCT
admet-2961	2	8	august	august	PROPN
admet-2961	2	9	17	17	NUM
admet-2961	2	10	,	,	PUNCT
admet-2961	2	11	2025	2025	NUM
admet-2961	2	12	;	;	PUNCT
admet-2961	2	13	revised	revise	VERB
admet-2961	2	14	:	:	PUNCT
admet-2961	2	15	october	october	PROPN
admet-2961	2	16	21	21	NUM
admet-2961	2	17	,	,	PUNCT
admet-2961	2	18	2025	2025	NUM
admet-2961	2	19	;	;	PUNCT
admet-2961	2	20	published	publish	VERB
admet-2961	2	21	:	:	PUNCT
admet-2961	2	22	october	october	PROPN
admet-2961	2	23	30	30	NUM
admet-2961	2	24	,	,	PUNCT
admet-2961	2	25	2025	2025	NUM
admet-2961	2	26	abstract	abstract	ADJ
admet-2961	2	27	background	background	NOUN
admet-2961	2	28	and	and	CCONJ
admet-2961	2	29	purpose	purpose	NOUN
admet-2961	2	30	:	:	PUNCT
admet-2961	2	31	as	as	ADP
admet-2961	2	32	a	a	DET
admet-2961	2	33	classic	classic	ADJ
admet-2961	2	34	β	β	NOUN
admet-2961	2	35	-	-	NOUN
admet-2961	2	36	blocker	blocker	NOUN
admet-2961	2	37	with	with	ADP
admet-2961	2	38	low	low	ADJ
admet-2961	2	39	systemic	systemic	ADJ
admet-2961	2	40	clearance	clearance	NOUN
admet-2961	2	41	,	,	PUNCT
admet-2961	2	42	metoprolol	metoprolol	PROPN
admet-2961	2	43	has	have	AUX
admet-2961	2	44	been	be	AUX
admet-2961	2	45	linked	link	VERB
admet-2961	2	46	to	to	ADP
admet-2961	2	47	rare	rare	ADJ
admet-2961	2	48	but	but	CCONJ
admet-2961	2	49	clinically	clinically	ADV
admet-2961	2	50	significant	significant	ADJ
admet-2961	2	51	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	2	52	,	,	PUNCT
admet-2961	2	53	yet	yet	CCONJ
admet-2961	2	54	its	its	PRON
admet-2961	2	55	hepatic	hepatic	ADJ
admet-2961	2	56	metabolic	metabolic	NOUN
admet-2961	2	57	fate	fate	NOUN
admet-2961	2	58	remains	remain	VERB
admet-2961	2	59	poorly	poorly	ADV
admet-2961	2	60	characterized	characterize	VERB
admet-2961	2	61	.	.	PUNCT
admet-2961	3	1	experimental	experimental	ADJ
admet-2961	3	2	approach	approach	NOUN
admet-2961	3	3	:	:	PUNCT
admet-2961	3	4	metoprolol	metoprolol	PROPN
admet-2961	3	5	was	be	AUX
admet-2961	3	6	incubated	incubate	VERB
admet-2961	3	7	individually	individually	ADV
admet-2961	3	8	in	in	ADP
admet-2961	3	9	plateable	plateable	ADJ
admet-2961	3	10	human	human	ADJ
admet-2961	3	11	and	and	CCONJ
admet-2961	3	12	animal	animal	NOUN
admet-2961	3	13	hepatocytes	hepatocyte	NOUN
admet-2961	3	14	,	,	PUNCT
admet-2961	3	15	and	and	CCONJ
admet-2961	3	16	recombinant	recombinant	ADJ
admet-2961	3	17	cytochrome	cytochrome	NOUN
admet-2961	3	18	(	(	PUNCT
admet-2961	3	19	cyp	cyp	ADJ
admet-2961	3	20	)	)	PUNCT
admet-2961	3	21	p450	p450	NUM
admet-2961	3	22	enzymes	enzyme	NOUN
admet-2961	3	23	,	,	PUNCT
admet-2961	3	24	followed	follow	VERB
admet-2961	3	25	by	by	ADP
admet-2961	3	26	sample	sample	NOUN
admet-2961	3	27	processing	processing	NOUN
admet-2961	3	28	for	for	ADP
admet-2961	3	29	cytotoxicity	cytotoxicity	NOUN
admet-2961	3	30	assessment	assessment	NOUN
admet-2961	3	31	,	,	PUNCT
admet-2961	3	32	stability	stability	NOUN
admet-2961	3	33	analysis	analysis	NOUN
admet-2961	3	34	,	,	PUNCT
admet-2961	3	35	phenotyping	phenotyping	NOUN
admet-2961	3	36	and	and	CCONJ
admet-2961	3	37	metabolite	metabolite	NOUN
admet-2961	3	38	identification	identification	NOUN
admet-2961	3	39	studies	study	NOUN
admet-2961	3	40	.	.	PUNCT
admet-2961	4	1	key	key	ADJ
admet-2961	4	2	results	result	NOUN
admet-2961	4	3	:	:	PUNCT
admet-2961	4	4	in	in	ADP
admet-2961	4	5	vitro	vitro	X
admet-2961	4	6	cytotoxicity	cytotoxicity	NOUN
admet-2961	4	7	assessment	assessment	NOUN
admet-2961	4	8	revealed	reveal	VERB
admet-2961	4	9	distinct	distinct	ADJ
admet-2961	4	10	species	specie	NOUN
admet-2961	4	11	-	-	PUNCT
admet-2961	4	12	specific	specific	ADJ
admet-2961	4	13	responses	response	NOUN
admet-2961	4	14	to	to	ADP
admet-2961	4	15	metoprolol	metoprolol	PROPN
admet-2961	4	16	exposure	exposure	NOUN
admet-2961	4	17	.	.	PUNCT
admet-2961	5	1	metoprolol	metoprolol	PROPN
admet-2961	5	2	showed	show	VERB
admet-2961	5	3	no	no	DET
admet-2961	5	4	observable	observable	ADJ
admet-2961	5	5	cytotoxicity	cytotoxicity	NOUN
admet-2961	5	6	across	across	ADP
admet-2961	5	7	the	the	DET
admet-2961	5	8	tested	test	VERB
admet-2961	5	9	concentration	concentration	NOUN
admet-2961	5	10	range	range	NOUN
admet-2961	5	11	(	(	PUNCT
admet-2961	5	12	0	0	NUM
admet-2961	5	13	to	to	PART
admet-2961	5	14	500	500	NUM
admet-2961	5	15	µm	µm	NOUN
admet-2961	5	16	)	)	PUNCT
admet-2961	5	17	in	in	ADP
admet-2961	5	18	human	human	ADJ
admet-2961	5	19	hepatocytes	hepatocyte	NOUN
admet-2961	5	20	,	,	PUNCT
admet-2961	5	21	whereas	whereas	SCONJ
admet-2961	5	22	it	it	PRON
admet-2961	5	23	was	be	AUX
admet-2961	5	24	cytotoxic	cytotoxic	ADJ
admet-2961	5	25	only	only	ADV
admet-2961	5	26	at	at	ADP
admet-2961	5	27	a	a	DET
admet-2961	5	28	concentration	concentration	NOUN
admet-2961	5	29	of	of	ADP
admet-2961	5	30	500	500	NUM
admet-2961	5	31	µm	µm	NOUN
admet-2961	5	32	in	in	ADP
admet-2961	5	33	rat	rat	NOUN
admet-2961	5	34	hepatocytes	hepatocyte	NOUN
admet-2961	5	35	.	.	PUNCT
admet-2961	6	1	metabolic	metabolic	NOUN
admet-2961	6	2	characterization	characterization	NOUN
admet-2961	6	3	showed	show	VERB
admet-2961	6	4	low	low	ADJ
admet-2961	6	5	intrinsic	intrinsic	ADJ
admet-2961	6	6	clearance	clearance	NOUN
admet-2961	6	7	in	in	ADP
admet-2961	6	8	human	human	ADJ
admet-2961	6	9	hepatocytes	hepatocyte	NOUN
admet-2961	6	10	(	(	PUNCT
admet-2961	6	11	0.56±0.12	0.56±0.12	NOUN
admet-2961	6	12	µl	µl	ADP
admet-2961	6	13	min-1	min-1	NOUN
admet-2961	6	14	per	per	ADP
admet-2961	6	15	million	million	NUM
admet-2961	6	16	cells	cell	NOUN
admet-2961	6	17	)	)	PUNCT
admet-2961	6	18	over	over	ADP
admet-2961	6	19	a	a	DET
admet-2961	6	20	72	72	NUM
admet-2961	6	21	-	-	PUNCT
admet-2961	6	22	hour	hour	NOUN
admet-2961	6	23	incubation	incubation	NOUN
admet-2961	6	24	.	.	PUNCT
admet-2961	7	1	comprehensive	comprehensive	ADJ
admet-2961	7	2	mass	mass	PROPN
admet-2961	7	3	spectrometer	spectrometer	NOUN
admet-2961	7	4	analysis	analysis	NOUN
admet-2961	7	5	identified	identify	VERB
admet-2961	7	6	22	22	NUM
admet-2961	7	7	metabolites	metabolite	NOUN
admet-2961	7	8	across	across	ADP
admet-2961	7	9	four	four	NUM
admet-2961	7	10	species	specie	NOUN
admet-2961	7	11	(	(	PUNCT
admet-2961	7	12	rat	rat	NOUN
admet-2961	7	13	,	,	PUNCT
admet-2961	7	14	dog	dog	NOUN
admet-2961	7	15	,	,	PUNCT
admet-2961	7	16	monkey	monkey	NOUN
admet-2961	7	17	,	,	PUNCT
admet-2961	7	18	and	and	CCONJ
admet-2961	7	19	human	human	NOUN
admet-2961	7	20	)	)	PUNCT
admet-2961	7	21	and	and	CCONJ
admet-2961	7	22	fifteen	fifteen	NUM
admet-2961	7	23	metabolites	metabolite	NOUN
admet-2961	7	24	were	be	AUX
admet-2961	7	25	identified	identify	VERB
admet-2961	7	26	as	as	ADP
admet-2961	7	27	the	the	DET
admet-2961	7	28	new	new	ADJ
admet-2961	7	29	ones	one	NOUN
admet-2961	7	30	,	,	PUNCT
admet-2961	7	31	with	with	ADP
admet-2961	7	32	cyp2d6	cyp2d6	NOUN
admet-2961	7	33	-	-	PUNCT
admet-2961	7	34	mediated	mediate	VERB
admet-2961	7	35	biotransformation	biotransformation	NOUN
admet-2961	7	36	pathways	pathway	NOUN
admet-2961	7	37	(	(	PUNCT
admet-2961	7	38	including	include	VERB
admet-2961	7	39	mono	mono	NOUN
admet-2961	7	40	-	-	PUNCT
admet-2961	7	41	oxygenation	oxygenation	NOUN
admet-2961	7	42	,	,	PUNCT
admet-2961	7	43	o	o	NOUN
admet-2961	7	44	-	-	NOUN
admet-2961	7	45	demethylation	demethylation	NOUN
admet-2961	7	46	,	,	PUNCT
admet-2961	7	47	and	and	CCONJ
admet-2961	7	48	oxidation	oxidation	NOUN
admet-2961	7	49	)	)	PUNCT
admet-2961	7	50	accounting	account	VERB
admet-2961	7	51	for	for	ADP
admet-2961	7	52	the	the	DET
admet-2961	7	53	generation	generation	NOUN
admet-2961	7	54	of	of	ADP
admet-2961	7	55	four	four	NUM
admet-2961	7	56	major	major	ADJ
admet-2961	7	57	metabolites	metabolite	NOUN
admet-2961	7	58	(	(	PUNCT
admet-2961	7	59	m1	m1	NOUN
admet-2961	7	60	,	,	PUNCT
admet-2961	7	61	m10	m10	PROPN
admet-2961	7	62	,	,	PUNCT
admet-2961	7	63	m13	m13	PROPN
admet-2961	7	64	,	,	PUNCT
admet-2961	7	65	m17	m17	PROPN
admet-2961	7	66	)	)	PUNCT
admet-2961	7	67	.	.	PUNCT
admet-2961	8	1	notably	notably	ADV
admet-2961	8	2	,	,	PUNCT
admet-2961	8	3	species	species	NOUN
admet-2961	8	4	-	-	PUNCT
admet-2961	8	5	specific	specific	ADJ
admet-2961	8	6	metabolism	metabolism	NOUN
admet-2961	8	7	was	be	AUX
admet-2961	8	8	observed	observe	VERB
admet-2961	8	9	for	for	ADP
admet-2961	8	10	-hydroxy	-hydroxy	PROPN
admet-2961	8	11	-	-	PUNCT
admet-2961	8	12	metoprolol	metoprolol	PROPN
admet-2961	8	13	(	(	PUNCT
admet-2961	8	14	m10	m10	PROPN
admet-2961	8	15	)	)	PUNCT
admet-2961	8	16	.	.	PUNCT
admet-2961	9	1	it	it	PRON
admet-2961	9	2	served	serve	VERB
admet-2961	9	3	as	as	ADP
admet-2961	9	4	the	the	DET
admet-2961	9	5	predominant	predominant	ADJ
admet-2961	9	6	metabolite	metabolite	NOUN
admet-2961	9	7	in	in	ADP
admet-2961	9	8	rat	rat	NOUN
admet-2961	9	9	hepatocytes	hepatocyte	NOUN
admet-2961	9	10	and	and	CCONJ
admet-2961	9	11	underwent	undergo	VERB
admet-2961	9	12	subsequent	subsequent	ADJ
admet-2961	9	13	bioactivation	bioactivation	NOUN
admet-2961	9	14	to	to	ADP
admet-2961	9	15	a	a	DET
admet-2961	9	16	reactive	reactive	ADJ
admet-2961	9	17	glutathione	glutathione	NOUN
admet-2961	9	18	(	(	PUNCT
admet-2961	9	19	gsh	gsh	PROPN
admet-2961	9	20	)	)	PUNCT
admet-2961	9	21	conjugate	conjugate	VERB
admet-2961	9	22	.	.	PUNCT
admet-2961	10	1	inhibition	inhibition	NOUN
admet-2961	10	2	studies	study	NOUN
admet-2961	10	3	with	with	ADP
admet-2961	10	4	1	1	NUM
admet-2961	10	5	-	-	PUNCT
admet-2961	10	6	aminobenzotriazole	aminobenzotriazole	NOUN
admet-2961	10	7	(	(	PUNCT
admet-2961	10	8	a	a	DET
admet-2961	10	9	non	non	ADJ
admet-2961	10	10	-	-	ADJ
admet-2961	10	11	specific	specific	ADJ
admet-2961	10	12	cyp	cyp	ADJ
admet-2961	10	13	inhibitor	inhibitor	NOUN
admet-2961	10	14	)	)	PUNCT
admet-2961	10	15	confirmed	confirm	VERB
admet-2961	10	16	the	the	DET
admet-2961	10	17	cyp	cyp	ADJ
admet-2961	10	18	-	-	PUNCT
admet-2961	10	19	dependent	dependent	ADJ
admet-2961	10	20	nature	nature	NOUN
admet-2961	10	21	of	of	ADP
admet-2961	10	22	this	this	DET
admet-2961	10	23	hepatotoxic	hepatotoxic	ADJ
admet-2961	10	24	metabolic	metabolic	NOUN
admet-2961	10	25	pathway	pathway	NOUN
admet-2961	10	26	.	.	PUNCT
admet-2961	11	1	conclusion	conclusion	NOUN
admet-2961	11	2	:	:	PUNCT
admet-2961	11	3	the	the	DET
admet-2961	11	4	sustained	sustained	ADJ
admet-2961	11	5	metabolic	metabolic	NOUN
admet-2961	11	6	activity	activity	NOUN
admet-2961	11	7	of	of	ADP
admet-2961	11	8	plateable	plateable	ADJ
admet-2961	11	9	hepatocytes	hepatocyte	NOUN
admet-2961	11	10	facilitated	facilitate	VERB
admet-2961	11	11	a	a	DET
admet-2961	11	12	comprehensive	comprehensive	ADJ
admet-2961	11	13	metabolic	metabolic	NOUN
admet-2961	11	14	profiling	profiling	NOUN
admet-2961	11	15	of	of	ADP
admet-2961	11	16	metoprolol	metoprolol	PROPN
admet-2961	11	17	,	,	PUNCT
admet-2961	11	18	including	include	VERB
admet-2961	11	19	direct	direct	ADJ
admet-2961	11	20	observation	observation	NOUN
admet-2961	11	21	of	of	ADP
admet-2961	11	22	gsh	gsh	PROPN
admet-2961	11	23	-	-	PUNCT
admet-2961	11	24	mediated	mediate	VERB
admet-2961	11	25	bioactivation	bioactivation	NOUN
admet-2961	11	26	.	.	PUNCT
admet-2961	12	1	integrating	integrate	VERB
admet-2961	12	2	with	with	ADP
admet-2961	12	3	cytotoxicity	cytotoxicity	NOUN
admet-2961	12	4	data	datum	NOUN
admet-2961	12	5	,	,	PUNCT
admet-2961	12	6	these	these	DET
admet-2961	12	7	findings	finding	NOUN
admet-2961	12	8	offered	offer	VERB
admet-2961	12	9	crucial	crucial	ADJ
admet-2961	12	10	insights	insight	NOUN
admet-2961	12	11	into	into	ADP
admet-2961	12	12	its	its	PRON
admet-2961	12	13	hepatic	hepatic	ADJ
admet-2961	12	14	adverse	adverse	ADJ
admet-2961	12	15	effects	effect	NOUN
admet-2961	12	16	.	.	PUNCT
admet-2961	13	1	©	©	PROPN
admet-2961	13	2	2025	2025	NUM
admet-2961	13	3	by	by	ADP
admet-2961	13	4	the	the	DET
admet-2961	13	5	authors	author	NOUN
admet-2961	13	6	.	.	PUNCT
admet-2961	14	1	this	this	DET
admet-2961	14	2	article	article	NOUN
admet-2961	14	3	is	be	AUX
admet-2961	14	4	an	an	DET
admet-2961	14	5	open	open	ADJ
admet-2961	14	6	-	-	PUNCT
admet-2961	14	7	access	access	NOUN
admet-2961	14	8	article	article	NOUN
admet-2961	14	9	distributed	distribute	VERB
admet-2961	14	10	under	under	ADP
admet-2961	14	11	the	the	DET
admet-2961	14	12	terms	term	NOUN
admet-2961	14	13	and	and	CCONJ
admet-2961	14	14	conditions	condition	NOUN
admet-2961	14	15	of	of	ADP
admet-2961	14	16	the	the	DET
admet-2961	14	17	creative	creative	ADJ
admet-2961	14	18	commons	common	NOUN
admet-2961	14	19	attribution	attribution	NOUN
admet-2961	14	20	license	license	NOUN
admet-2961	14	21	(	(	PUNCT
admet-2961	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2961	14	23	)	)	PUNCT
admet-2961	14	24	.	.	PUNCT
admet-2961	15	1	keywords	keyword	NOUN
admet-2961	15	2	metabolite	metabolite	NOUN
admet-2961	15	3	;	;	PUNCT
admet-2961	15	4	cytotoxicity	cytotoxicity	NOUN
admet-2961	15	5	;	;	PUNCT
admet-2961	15	6	recombinant	recombinant	ADJ
admet-2961	15	7	;	;	PUNCT
admet-2961	15	8	low	low	ADJ
admet-2961	15	9	-	-	PUNCT
admet-2961	15	10	clearance	clearance	NOUN
admet-2961	15	11	;	;	PUNCT
admet-2961	15	12	glutathione	glutathione	NOUN
admet-2961	15	13	;	;	PUNCT
admet-2961	15	14	cyp2d6	cyp2d6	NOUN
admet-2961	15	15	introduction	introduction	NOUN
admet-2961	15	16	hepatic	hepatic	ADJ
admet-2961	15	17	metabolism	metabolism	NOUN
admet-2961	15	18	is	be	AUX
admet-2961	15	19	the	the	DET
admet-2961	15	20	primary	primary	ADJ
admet-2961	15	21	pathway	pathway	NOUN
admet-2961	15	22	for	for	ADP
admet-2961	15	23	clearing	clear	VERB
admet-2961	15	24	xenobiotic	xenobiotic	ADJ
admet-2961	15	25	compounds	compound	NOUN
admet-2961	15	26	from	from	ADP
admet-2961	15	27	the	the	DET
admet-2961	15	28	body	body	NOUN
admet-2961	15	29	.	.	PUNCT
admet-2961	16	1	approximately	approximately	ADV
admet-2961	16	2	70	70	NUM
admet-2961	16	3	%	%	NOUN
admet-2961	16	4	of	of	ADP
admet-2961	16	5	marketed	market	VERB
admet-2961	16	6	pharmaceuticals	pharmaceutical	NOUN
admet-2961	16	7	are	be	AUX
admet-2961	16	8	metabolized	metabolize	VERB
admet-2961	16	9	in	in	ADP
admet-2961	16	10	the	the	DET
admet-2961	16	11	liver	liver	NOUN
admet-2961	16	12	through	through	ADP
admet-2961	16	13	its	its	PRON
admet-2961	16	14	detoxification	detoxification	NOUN
admet-2961	16	15	functions	function	NOUN
admet-2961	16	16	[	[	X
admet-2961	16	17	1,2	1,2	NUM
admet-2961	16	18	]	]	PUNCT
admet-2961	16	19	.	.	PUNCT
admet-2961	17	1	it	it	PRON
admet-2961	17	2	is	be	AUX
admet-2961	17	3	well	well	ADV
admet-2961	17	4	established	establish	VERB
admet-2961	17	5	that	that	PRON
admet-2961	17	6	high	high	ADJ
admet-2961	17	7	hepatic	hepatic	ADJ
admet-2961	17	8	clearance	clearance	NOUN
admet-2961	17	9	often	often	ADV
admet-2961	17	10	results	result	VERB
admet-2961	17	11	in	in	ADP
admet-2961	17	12	low	low	ADJ
admet-2961	17	13	systemic	systemic	ADJ
admet-2961	17	14	bioavailability	bioavailability	NOUN
admet-2961	17	15	.	.	PUNCT
admet-2961	18	1	conversely	conversely	ADV
admet-2961	18	2	,	,	PUNCT
admet-2961	18	3	a	a	DET
admet-2961	18	4	detailed	detailed	ADJ
admet-2961	18	5	understanding	understanding	NOUN
admet-2961	18	6	of	of	ADP
admet-2961	18	7	hepatic	hepatic	ADJ
admet-2961	18	8	metabolism	metabolism	NOUN
admet-2961	18	9	can	can	AUX
admet-2961	18	10	support	support	VERB
admet-2961	18	11	drug	drug	NOUN
admet-2961	18	12	optimization	optimization	NOUN
admet-2961	18	13	efforts	effort	NOUN
admet-2961	18	14	by	by	ADP
admet-2961	18	15	revealing	reveal	VERB
admet-2961	18	16	metabolic	metabolic	NOUN
admet-2961	18	17	soft	soft	ADJ
admet-2961	18	18	spots	spot	NOUN
admet-2961	18	19	in	in	ADP
admet-2961	18	20	lead	lead	ADJ
admet-2961	18	21	compounds	compound	NOUN
admet-2961	18	22	[	[	X
admet-2961	18	23	3	3	NUM
admet-2961	18	24	]	]	PUNCT
admet-2961	18	25	.	.	PUNCT
admet-2961	19	1	consequently	consequently	ADV
admet-2961	19	2	,	,	PUNCT
admet-2961	19	3	hepatocytes	hepatocyte	NOUN
admet-2961	19	4	play	play	VERB
admet-2961	19	5	an	an	DET
admet-2961	19	6	indispensable	indispensable	ADJ
admet-2961	19	7	role	role	NOUN
admet-2961	19	8	in	in	ADP
admet-2961	19	9	drug	drug	NOUN
admet-2961	19	10	discovery	discovery	NOUN
admet-2961	19	11	.	.	PUNCT
admet-2961	20	1	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	20	2	https://doi.org/10.5599/admet.2961	https://doi.org/10.5599/admet.2961	PROPN
admet-2961	20	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-2961	20	4	mailto:wanyong.feng@bioduro.com	mailto:wanyong.feng@bioduro.com	X
admet-2961	21	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2961	21	2	j.	j.	PROPN
admet-2961	21	3	pu	pu	PROPN
admet-2961	21	4	et	et	PROPN
admet-2961	21	5	al	al	PROPN
admet-2961	21	6	.	.	PROPN
admet-2961	21	7	admet	admet	PROPN
admet-2961	21	8	&	&	CCONJ
admet-2961	21	9	dmpk	dmpk	PROPN
admet-2961	21	10	13(5	13(5	NUM
admet-2961	21	11	)	)	PUNCT
admet-2961	21	12	(	(	PUNCT
admet-2961	21	13	2025	2025	NUM
admet-2961	21	14	)	)	PUNCT
admet-2961	21	15	2961	2961	NUM
admet-2961	21	16	2	2	NUM
admet-2961	21	17	hepatocytes	hepatocyte	NOUN
admet-2961	21	18	are	be	AUX
admet-2961	21	19	the	the	DET
admet-2961	21	20	preferred	prefer	VERB
admet-2961	21	21	in	in	ADP
admet-2961	21	22	vitro	vitro	X
admet-2961	21	23	model	model	NOUN
admet-2961	21	24	for	for	ADP
admet-2961	21	25	metabolism	metabolism	NOUN
admet-2961	21	26	studies	study	NOUN
admet-2961	21	27	due	due	ADP
admet-2961	21	28	to	to	ADP
admet-2961	21	29	their	their	PRON
admet-2961	21	30	complete	complete	ADJ
admet-2961	21	31	complement	complement	NOUN
admet-2961	21	32	of	of	ADP
admet-2961	21	33	phase	phase	NOUN
admet-2961	21	34	i	i	PRON
admet-2961	21	35	and	and	CCONJ
admet-2961	21	36	ii	ii	PROPN
admet-2961	21	37	enzymes	enzyme	NOUN
admet-2961	21	38	,	,	PUNCT
admet-2961	21	39	which	which	PRON
admet-2961	21	40	accurately	accurately	ADV
admet-2961	21	41	recapitulate	recapitulate	VERB
admet-2961	21	42	intrinsic	intrinsic	ADJ
admet-2961	21	43	clearance	clearance	NOUN
admet-2961	21	44	mechanisms	mechanism	NOUN
admet-2961	21	45	[	[	X
admet-2961	21	46	4	4	NUM
admet-2961	21	47	-	-	SYM
admet-2961	21	48	13	13	NUM
admet-2961	21	49	]	]	PUNCT
admet-2961	21	50	.	.	PUNCT
admet-2961	22	1	these	these	DET
admet-2961	22	2	cells	cell	NOUN
admet-2961	22	3	also	also	ADV
admet-2961	22	4	express	express	VERB
admet-2961	22	5	the	the	DET
admet-2961	22	6	full	full	ADJ
admet-2961	22	7	spectrum	spectrum	NOUN
admet-2961	22	8	of	of	ADP
admet-2961	22	9	hepatic	hepatic	ADJ
admet-2961	22	10	transporters	transporter	NOUN
admet-2961	22	11	that	that	PRON
admet-2961	22	12	govern	govern	VERB
admet-2961	22	13	drug	drug	NOUN
admet-2961	22	14	uptake	uptake	NOUN
admet-2961	22	15	and	and	CCONJ
admet-2961	22	16	efflux	efflux	VERB
admet-2961	22	17	,	,	PUNCT
admet-2961	22	18	providing	provide	VERB
admet-2961	22	19	a	a	DET
admet-2961	22	20	physiologically	physiologically	ADV
admet-2961	22	21	relevant	relevant	ADJ
admet-2961	22	22	platform	platform	NOUN
admet-2961	22	23	for	for	ADP
admet-2961	22	24	disposition	disposition	NOUN
admet-2961	22	25	studies	study	NOUN
admet-2961	22	26	[	[	X
admet-2961	22	27	14,15	14,15	NUM
admet-2961	22	28	]	]	PUNCT
admet-2961	22	29	.	.	PUNCT
admet-2961	23	1	notably	notably	ADV
admet-2961	23	2	,	,	PUNCT
admet-2961	23	3	comparative	comparative	ADJ
admet-2961	23	4	metabolite	metabolite	NOUN
admet-2961	23	5	profiling	profiling	NOUN
admet-2961	23	6	across	across	ADP
admet-2961	23	7	species	specie	NOUN
admet-2961	23	8	-	-	PUNCT
admet-2961	23	9	specific	specific	ADJ
admet-2961	23	10	hepatocytes	hepatocyte	NOUN
admet-2961	23	11	enables	enable	VERB
admet-2961	23	12	prediction	prediction	NOUN
admet-2961	23	13	of	of	ADP
admet-2961	23	14	interspecies	interspecie	NOUN
admet-2961	23	15	metabolic	metabolic	NOUN
admet-2961	23	16	differences	difference	NOUN
admet-2961	23	17	,	,	PUNCT
admet-2961	23	18	thereby	thereby	ADV
admet-2961	23	19	informing	inform	VERB
admet-2961	23	20	appropriate	appropriate	ADJ
admet-2961	23	21	animal	animal	NOUN
admet-2961	23	22	model	model	NOUN
admet-2961	23	23	selection	selection	NOUN
admet-2961	23	24	for	for	ADP
admet-2961	23	25	preclinical	preclinical	ADJ
admet-2961	23	26	toxicology	toxicology	NOUN
admet-2961	23	27	assessments	assessment	NOUN
admet-2961	23	28	[	[	X
admet-2961	23	29	16,17	16,17	NUM
admet-2961	23	30	]	]	PUNCT
admet-2961	23	31	.	.	PUNCT
admet-2961	24	1	recent	recent	ADJ
admet-2961	24	2	years	year	NOUN
admet-2961	24	3	have	have	AUX
admet-2961	24	4	witnessed	witness	VERB
admet-2961	24	5	notable	notable	ADJ
admet-2961	24	6	advancements	advancement	NOUN
admet-2961	24	7	in	in	ADP
admet-2961	24	8	hepatocyte	hepatocyte	NOUN
admet-2961	24	9	systems	system	NOUN
admet-2961	24	10	for	for	ADP
admet-2961	24	11	low	low	ADJ
admet-2961	24	12	-	-	PUNCT
admet-2961	24	13	clearance	clearance	NOUN
admet-2961	24	14	compound	compound	NOUN
admet-2961	24	15	assessment	assessment	NOUN
admet-2961	24	16	,	,	PUNCT
admet-2961	24	17	including	include	VERB
admet-2961	24	18	suspended	suspend	VERB
admet-2961	24	19	hepatocytes	hepatocyte	NOUN
admet-2961	24	20	and	and	CCONJ
admet-2961	24	21	adherent	adherent	ADJ
admet-2961	24	22	primary	primary	ADJ
admet-2961	24	23	hepatocytes	hepatocyte	NOUN
admet-2961	24	24	,	,	PUNCT
admet-2961	24	25	heparg	heparg	NOUN
admet-2961	24	26	cells	cell	NOUN
admet-2961	24	27	[	[	X
admet-2961	24	28	18	18	NUM
admet-2961	24	29	-	-	SYM
admet-2961	24	30	25	25	NUM
admet-2961	24	31	]	]	PUNCT
admet-2961	24	32	,	,	PUNCT
admet-2961	24	33	and	and	CCONJ
admet-2961	24	34	various	various	ADJ
admet-2961	24	35	hepatocyte	hepatocyte	ADJ
admet-2961	24	36	-	-	PUNCT
admet-2961	24	37	stromal	stromal	ADJ
admet-2961	24	38	cell	cell	NOUN
admet-2961	24	39	cocultures	coculture	VERB
admet-2961	25	1	[	[	X
admet-2961	25	2	26	26	NUM
admet-2961	25	3	-	-	SYM
admet-2961	25	4	47	47	NUM
admet-2961	25	5	]	]	PUNCT
admet-2961	25	6	.	.	PUNCT
admet-2961	26	1	adherent	adherent	ADJ
admet-2961	26	2	primary	primary	ADJ
admet-2961	26	3	hepatocytes	hepatocyte	NOUN
admet-2961	26	4	are	be	AUX
admet-2961	26	5	optimal	optimal	ADJ
admet-2961	26	6	for	for	ADP
admet-2961	26	7	lowclearance	lowclearance	NOUN
admet-2961	26	8	compound	compound	NOUN
admet-2961	26	9	studies	study	NOUN
admet-2961	26	10	due	due	ADP
admet-2961	26	11	to	to	ADP
admet-2961	26	12	their	their	PRON
admet-2961	26	13	stable	stable	ADJ
admet-2961	26	14	metabolic	metabolic	NOUN
admet-2961	26	15	function	function	NOUN
admet-2961	26	16	and	and	CCONJ
admet-2961	26	17	intact	intact	ADJ
admet-2961	26	18	enzyme	enzyme	NOUN
admet-2961	26	19	systems	system	NOUN
admet-2961	26	20	in	in	ADP
admet-2961	26	21	extended	extended	ADJ
admet-2961	26	22	cultures	culture	NOUN
admet-2961	26	23	.	.	PUNCT
admet-2961	27	1	traditional	traditional	ADJ
admet-2961	27	2	hepatocellular	hepatocellular	ADJ
admet-2961	27	3	carcinoma	carcinoma	NOUN
admet-2961	27	4	cell	cell	NOUN
admet-2961	27	5	lines	line	NOUN
admet-2961	27	6	are	be	AUX
admet-2961	27	7	limited	limit	VERB
admet-2961	27	8	by	by	ADP
admet-2961	27	9	genetic	genetic	ADJ
admet-2961	27	10	instability	instability	NOUN
admet-2961	27	11	and	and	CCONJ
admet-2961	27	12	progressive	progressive	ADJ
admet-2961	27	13	phenotypic	phenotypic	ADJ
admet-2961	27	14	drift	drift	NOUN
admet-2961	27	15	,	,	PUNCT
admet-2961	27	16	and	and	CCONJ
admet-2961	27	17	coculture	coculture	NOUN
admet-2961	27	18	systems	system	NOUN
admet-2961	27	19	present	present	VERB
admet-2961	27	20	operational	operational	ADJ
admet-2961	27	21	challenges	challenge	NOUN
admet-2961	27	22	due	due	ADP
admet-2961	27	23	to	to	ADP
admet-2961	27	24	the	the	DET
admet-2961	27	25	biological	biological	ADJ
admet-2961	27	26	complexity	complexity	NOUN
admet-2961	27	27	imposed	impose	VERB
admet-2961	27	28	by	by	ADP
admet-2961	27	29	heterologous	heterologous	ADJ
admet-2961	27	30	cellular	cellular	ADJ
admet-2961	27	31	components	component	NOUN
admet-2961	27	32	.	.	PUNCT
admet-2961	28	1	although	although	SCONJ
admet-2961	28	2	suspended	suspend	VERB
admet-2961	28	3	hepatocytes	hepatocyte	NOUN
admet-2961	28	4	are	be	AUX
admet-2961	28	5	commonly	commonly	ADV
admet-2961	28	6	used	use	VERB
admet-2961	28	7	for	for	ADP
admet-2961	28	8	metabolic	metabolic	NOUN
admet-2961	28	9	screening	screening	NOUN
admet-2961	28	10	,	,	PUNCT
admet-2961	28	11	their	their	PRON
admet-2961	28	12	utility	utility	NOUN
admet-2961	28	13	is	be	AUX
admet-2961	28	14	severely	severely	ADV
admet-2961	28	15	hampered	hamper	VERB
admet-2961	28	16	by	by	ADP
admet-2961	28	17	the	the	DET
admet-2961	28	18	rapid	rapid	ADJ
admet-2961	28	19	loss	loss	NOUN
admet-2961	28	20	of	of	ADP
admet-2961	28	21	enzymatic	enzymatic	ADJ
admet-2961	28	22	activity	activity	NOUN
admet-2961	28	23	within	within	ADP
admet-2961	28	24	4	4	NUM
admet-2961	28	25	hours	hour	NOUN
admet-2961	29	1	[	[	X
admet-2961	29	2	25,42,48	25,42,48	NUM
admet-2961	29	3	]	]	X
admet-2961	29	4	.	.	PUNCT
admet-2961	30	1	methods	method	NOUN
admet-2961	30	2	like	like	ADP
admet-2961	30	3	the	the	DET
admet-2961	30	4	relay	relay	NOUN
admet-2961	30	5	technique	technique	NOUN
admet-2961	30	6	[	[	X
admet-2961	30	7	24	24	NUM
admet-2961	30	8	]	]	PUNCT
admet-2961	30	9	extend	extend	VERB
admet-2961	30	10	observation	observation	NOUN
admet-2961	30	11	periods	period	NOUN
admet-2961	30	12	via	via	ADP
admet-2961	30	13	sequential	sequential	ADJ
admet-2961	30	14	incubations	incubation	NOUN
admet-2961	30	15	but	but	CCONJ
admet-2961	30	16	complicate	complicate	VERB
admet-2961	30	17	routine	routine	ADJ
admet-2961	30	18	application	application	NOUN
admet-2961	30	19	[	[	X
admet-2961	30	20	42,49	42,49	NOUN
admet-2961	30	21	]	]	PUNCT
admet-2961	30	22	.	.	PUNCT
admet-2961	31	1	in	in	ADP
admet-2961	31	2	contrast	contrast	NOUN
admet-2961	31	3	,	,	PUNCT
admet-2961	31	4	adherent	adherent	ADJ
admet-2961	31	5	primary	primary	ADJ
admet-2961	31	6	hepatocytes	hepatocyte	NOUN
admet-2961	31	7	maintain	maintain	VERB
admet-2961	31	8	robust	robust	ADJ
admet-2961	31	9	metabolic	metabolic	NOUN
admet-2961	31	10	enzyme	enzyme	NOUN
admet-2961	31	11	activity	activity	NOUN
admet-2961	31	12	and	and	CCONJ
admet-2961	31	13	intact	intact	ADJ
admet-2961	31	14	hepatic	hepatic	ADJ
admet-2961	31	15	enzymatic	enzymatic	ADJ
admet-2961	31	16	profiles	profile	NOUN
admet-2961	31	17	without	without	ADP
admet-2961	31	18	artificial	artificial	ADJ
admet-2961	31	19	modification	modification	NOUN
admet-2961	31	20	,	,	PUNCT
admet-2961	31	21	rendering	render	VERB
admet-2961	31	22	them	they	PRON
admet-2961	31	23	the	the	DET
admet-2961	31	24	most	most	ADV
admet-2961	31	25	physiologically	physiologically	ADV
admet-2961	31	26	relevant	relevant	ADJ
admet-2961	31	27	in	in	ADP
admet-2961	31	28	vitro	vitro	X
admet-2961	31	29	model	model	NOUN
admet-2961	31	30	for	for	ADP
admet-2961	31	31	prolonged	prolonged	ADJ
admet-2961	31	32	clearance	clearance	NOUN
admet-2961	31	33	studies	study	NOUN
admet-2961	31	34	[	[	X
admet-2961	31	35	50	50	NUM
admet-2961	31	36	-	-	SYM
admet-2961	31	37	52	52	NUM
admet-2961	31	38	]	]	PUNCT
admet-2961	31	39	.	.	PUNCT
admet-2961	32	1	compelling	compelling	ADJ
admet-2961	32	2	evidence	evidence	NOUN
admet-2961	32	3	from	from	ADP
admet-2961	32	4	griffin	griffin	PROPN
admet-2961	32	5	et	et	PROPN
admet-2961	32	6	al	al	PROPN
admet-2961	32	7	.	.	PUNCT
admet-2961	33	1	[	[	X
admet-2961	33	2	53	53	NUM
admet-2961	33	3	]	]	PUNCT
admet-2961	33	4	demonstrated	demonstrate	VERB
admet-2961	33	5	superior	superior	ADJ
admet-2961	33	6	performance	performance	NOUN
admet-2961	33	7	of	of	ADP
admet-2961	33	8	plateable	plateable	ADJ
admet-2961	33	9	rat	rat	NOUN
admet-2961	33	10	hepatocytes	hepatocyte	NOUN
admet-2961	33	11	compared	compare	VERB
admet-2961	33	12	to	to	ADP
admet-2961	33	13	suspended	suspend	VERB
admet-2961	33	14	cells	cell	NOUN
admet-2961	33	15	for	for	ADP
admet-2961	33	16	low	low	ADJ
admet-2961	33	17	-	-	PUNCT
admet-2961	33	18	clearance	clearance	NOUN
admet-2961	33	19	measurements	measurement	NOUN
admet-2961	33	20	.	.	PUNCT
admet-2961	34	1	subsequent	subsequent	ADJ
admet-2961	34	2	human	human	ADJ
admet-2961	34	3	hepatocyte	hepatocyte	PROPN
admet-2961	34	4	studies	study	NOUN
admet-2961	34	5	have	have	AUX
admet-2961	34	6	validated	validate	VERB
admet-2961	34	7	the	the	DET
admet-2961	34	8	reliability	reliability	NOUN
admet-2961	34	9	of	of	ADP
admet-2961	34	10	adherent	adherent	ADJ
admet-2961	34	11	systems	system	NOUN
admet-2961	34	12	for	for	ADP
admet-2961	34	13	evaluating	evaluate	VERB
admet-2961	34	14	low	low	ADJ
admet-2961	34	15	-	-	PUNCT
admet-2961	34	16	clearance	clearance	NOUN
admet-2961	34	17	compounds	compound	NOUN
admet-2961	34	18	[	[	X
admet-2961	34	19	20,54	20,54	NUM
admet-2961	34	20	]	]	PUNCT
admet-2961	34	21	.	.	PUNCT
admet-2961	35	1	despite	despite	SCONJ
admet-2961	35	2	being	be	AUX
admet-2961	35	3	extensively	extensively	ADV
admet-2961	35	4	utilized	utilize	VERB
admet-2961	35	5	as	as	ADP
admet-2961	35	6	both	both	CCONJ
admet-2961	35	7	a	a	DET
admet-2961	35	8	cyp2d6	cyp2d6	NOUN
admet-2961	35	9	phenotyping	phenotype	VERB
admet-2961	35	10	probe	probe	NOUN
admet-2961	35	11	and	and	CCONJ
admet-2961	35	12	a	a	DET
admet-2961	35	13	model	model	NOUN
admet-2961	35	14	high	high	ADJ
admet-2961	35	15	-	-	PUNCT
admet-2961	35	16	permeability	permeability	NOUN
admet-2961	35	17	compound	compound	NOUN
admet-2961	35	18	exhibiting	exhibit	VERB
admet-2961	35	19	excellent	excellent	ADJ
admet-2961	35	20	oral	oral	ADJ
admet-2961	35	21	bioavailability	bioavailability	NOUN
admet-2961	35	22	[	[	X
admet-2961	35	23	55	55	NUM
admet-2961	35	24	-	-	SYM
admet-2961	35	25	59	59	NUM
admet-2961	35	26	]	]	PUNCT
admet-2961	35	27	,	,	PUNCT
admet-2961	35	28	metoprolol	metoprolol	PROPN
admet-2961	35	29	's	's	PART
admet-2961	35	30	complete	complete	ADJ
admet-2961	35	31	metabolic	metabolic	NOUN
admet-2961	35	32	disposition	disposition	NOUN
admet-2961	35	33	as	as	ADP
admet-2961	35	34	a	a	DET
admet-2961	35	35	low	low	ADJ
admet-2961	35	36	-	-	PUNCT
admet-2961	35	37	clearance	clearance	NOUN
admet-2961	35	38	agent	agent	NOUN
admet-2961	35	39	[	[	X
admet-2961	35	40	60,61	60,61	NOUN
admet-2961	35	41	]	]	PUNCT
admet-2961	35	42	remains	remain	VERB
admet-2961	35	43	insufficiently	insufficiently	ADV
admet-2961	35	44	characterized	characterize	VERB
admet-2961	35	45	,	,	PUNCT
admet-2961	35	46	particularly	particularly	ADV
admet-2961	35	47	regarding	regard	VERB
admet-2961	35	48	its	its	PRON
admet-2961	35	49	hepatic	hepatic	ADJ
admet-2961	35	50	elimination	elimination	NOUN
admet-2961	35	51	pathways	pathway	NOUN
admet-2961	35	52	.	.	PUNCT
admet-2961	36	1	existing	exist	VERB
admet-2961	36	2	metabolite	metabolite	NOUN
admet-2961	36	3	identification	identification	NOUN
admet-2961	36	4	studies	study	NOUN
admet-2961	36	5	are	be	AUX
admet-2961	36	6	conducted	conduct	VERB
admet-2961	36	7	in	in	ADP
admet-2961	36	8	various	various	ADJ
admet-2961	36	9	matrices	matrix	NOUN
admet-2961	36	10	,	,	PUNCT
admet-2961	36	11	including	include	VERB
admet-2961	36	12	rat	rat	NOUN
admet-2961	36	13	plasma	plasma	NOUN
admet-2961	36	14	[	[	X
admet-2961	36	15	62,63	62,63	NOUN
admet-2961	36	16	]	]	PUNCT
admet-2961	36	17	,	,	PUNCT
admet-2961	36	18	human	human	ADJ
admet-2961	36	19	liver	liver	NOUN
admet-2961	36	20	microsomes	microsome	NOUN
admet-2961	36	21	,	,	PUNCT
admet-2961	36	22	plasma	plasma	NOUN
admet-2961	36	23	,	,	PUNCT
admet-2961	36	24	and	and	CCONJ
admet-2961	36	25	urine	urine	NOUN
admet-2961	36	26	[	[	X
admet-2961	36	27	57,64	57,64	NUM
admet-2961	36	28	-	-	SYM
admet-2961	36	29	68	68	NUM
admet-2961	36	30	]	]	PUNCT
admet-2961	36	31	,	,	PUNCT
admet-2961	36	32	as	as	ADV
admet-2961	36	33	well	well	ADV
admet-2961	36	34	as	as	ADP
admet-2961	36	35	dog	dog	NOUN
admet-2961	36	36	plasma	plasma	NOUN
admet-2961	36	37	[	[	X
admet-2961	36	38	69	69	NUM
admet-2961	36	39	]	]	PUNCT
admet-2961	36	40	.	.	PUNCT
admet-2961	37	1	only	only	ADV
admet-2961	37	2	minor	minor	ADJ
admet-2961	37	3	metabolites	metabolite	NOUN
admet-2961	37	4	are	be	AUX
admet-2961	37	5	reported	report	VERB
admet-2961	37	6	in	in	ADP
admet-2961	37	7	vivo	vivo	NOUN
admet-2961	37	8	,	,	PUNCT
admet-2961	37	9	a	a	DET
admet-2961	37	10	fact	fact	NOUN
admet-2961	37	11	attributed	attribute	VERB
admet-2961	37	12	to	to	ADP
admet-2961	37	13	the	the	DET
admet-2961	37	14	significant	significant	ADJ
admet-2961	37	15	renal	renal	ADJ
admet-2961	37	16	excretion	excretion	NOUN
admet-2961	37	17	.	.	PUNCT
admet-2961	38	1	moreover	moreover	ADV
admet-2961	38	2	,	,	PUNCT
admet-2961	38	3	even	even	ADV
admet-2961	38	4	fewer	few	ADJ
admet-2961	38	5	metabolites	metabolite	NOUN
admet-2961	38	6	are	be	AUX
admet-2961	38	7	typically	typically	ADV
admet-2961	38	8	observed	observe	VERB
admet-2961	38	9	in	in	ADP
admet-2961	38	10	vitro	vitro	X
admet-2961	38	11	under	under	ADP
admet-2961	38	12	short	short	ADJ
admet-2961	38	13	-	-	PUNCT
admet-2961	38	14	term	term	NOUN
admet-2961	38	15	incubation	incubation	NOUN
admet-2961	38	16	conditions	condition	NOUN
admet-2961	38	17	.	.	PUNCT
admet-2961	39	1	this	this	DET
admet-2961	39	2	study	study	NOUN
admet-2961	39	3	,	,	PUNCT
admet-2961	39	4	therefore	therefore	ADV
admet-2961	39	5	,	,	PUNCT
admet-2961	39	6	aims	aim	VERB
admet-2961	39	7	to	to	PART
admet-2961	39	8	systematically	systematically	ADV
admet-2961	39	9	characterize	characterize	VERB
admet-2961	39	10	metoprolol	metoprolol	NOUN
admet-2961	39	11	metabolism	metabolism	NOUN
admet-2961	39	12	using	use	VERB
admet-2961	39	13	plateable	plateable	ADJ
admet-2961	39	14	hepatocytes	hepatocyte	NOUN
admet-2961	39	15	with	with	ADP
admet-2961	39	16	longer	long	ADJ
admet-2961	39	17	extended	extend	VERB
admet-2961	39	18	culture	culture	NOUN
admet-2961	39	19	and	and	CCONJ
admet-2961	39	20	recombinant	recombinant	ADJ
admet-2961	39	21	enzymes	enzyme	NOUN
admet-2961	39	22	,	,	PUNCT
admet-2961	39	23	providing	provide	VERB
admet-2961	39	24	novel	novel	ADJ
admet-2961	39	25	insights	insight	NOUN
admet-2961	39	26	into	into	ADP
admet-2961	39	27	its	its	PRON
admet-2961	39	28	hepatic	hepatic	ADJ
admet-2961	39	29	adverse	adverse	ADJ
admet-2961	39	30	effects	effect	NOUN
admet-2961	39	31	.	.	PUNCT
admet-2961	40	1	experimental	experimental	ADJ
admet-2961	40	2	chemicals	chemical	NOUN
admet-2961	40	3	and	and	CCONJ
admet-2961	40	4	reagents	reagent	NOUN
admet-2961	40	5	metoprolol	metoprolol	NOUN
admet-2961	40	6	(	(	PUNCT
admet-2961	40	7	cas	cas	PROPN
admet-2961	40	8	:	:	PUNCT
admet-2961	40	9	51384	51384	NUM
admet-2961	40	10	-	-	SYM
admet-2961	40	11	51	51	NUM
admet-2961	40	12	-	-	SYM
admet-2961	40	13	1	1	NUM
admet-2961	40	14	,	,	PUNCT
admet-2961	40	15	lot	lot	NOUN
admet-2961	40	16	:	:	PUNCT
admet-2961	40	17	6	6	NUM
admet-2961	40	18	-	-	PUNCT
admet-2961	40	19	jkl-52	jkl-52	NOUN
admet-2961	40	20	-	-	PUNCT
admet-2961	40	21	4	4	NUM
admet-2961	40	22	)	)	PUNCT
admet-2961	40	23	was	be	AUX
admet-2961	40	24	purchased	purchase	VERB
admet-2961	40	25	from	from	ADP
admet-2961	40	26	trc	trc	PROPN
admet-2961	40	27	canada	canada	PROPN
admet-2961	40	28	,	,	PUNCT
admet-2961	40	29	while	while	SCONJ
admet-2961	40	30	α	α	NOUN
admet-2961	40	31	-	-	PUNCT
admet-2961	40	32	hydroxy	hydroxy	VERB
admet-2961	40	33	-	-	PUNCT
admet-2961	40	34	metoprolol	metoprolol	NOUN
admet-2961	40	35	(	(	PUNCT
admet-2961	40	36	cas	cas	PROPN
admet-2961	40	37	:	:	PUNCT
admet-2961	40	38	56392	56392	NUM
admet-2961	40	39	-	-	SYM
admet-2961	40	40	16	16	NUM
admet-2961	40	41	-	-	SYM
admet-2961	40	42	6	6	NUM
admet-2961	40	43	,	,	PUNCT
admet-2961	40	44	lot	lot	NOUN
admet-2961	40	45	:	:	PUNCT
admet-2961	40	46	h2429287	h2429287	NOUN
admet-2961	40	47	)	)	PUNCT
admet-2961	40	48	and	and	CCONJ
admet-2961	40	49	metoprolol	metoprolol	PROPN
admet-2961	40	50	acid	acid	PROPN
admet-2961	40	51	(	(	PUNCT
admet-2961	40	52	cas	cas	PROPN
admet-2961	40	53	:	:	PUNCT
admet-2961	40	54	56392	56392	NUM
admet-2961	40	55	-	-	SYM
admet-2961	40	56	14	14	NUM
admet-2961	40	57	-	-	SYM
admet-2961	40	58	4	4	NUM
admet-2961	40	59	,	,	PUNCT
admet-2961	40	60	lot	lot	NOUN
admet-2961	40	61	:	:	PUNCT
admet-2961	40	62	l2213483	l2213483	NOUN
admet-2961	40	63	)	)	PUNCT
admet-2961	40	64	were	be	AUX
admet-2961	40	65	obtained	obtain	VERB
admet-2961	40	66	from	from	ADP
admet-2961	40	67	aladdin	aladdin	VERB
admet-2961	40	68	.	.	PUNCT
admet-2961	41	1	hepatocytes	hepatocytes	PROPN
admet-2961	41	2	from	from	ADP
admet-2961	41	3	male	male	ADJ
admet-2961	41	4	sprague	sprague	NOUN
admet-2961	41	5	-	-	PUNCT
admet-2961	41	6	dawley	dawley	NOUN
admet-2961	41	7	rats	rat	NOUN
admet-2961	41	8	(	(	PUNCT
admet-2961	41	9	hep134054	hep134054	NOUN
admet-2961	41	10	,	,	PUNCT
admet-2961	41	11	10	10	NUM
admet-2961	41	12	donors	donor	NOUN
admet-2961	41	13	)	)	PUNCT
admet-2961	41	14	,	,	PUNCT
admet-2961	41	15	male	male	ADJ
admet-2961	41	16	beagle	beagle	NOUN
admet-2961	41	17	dogs	dog	NOUN
admet-2961	41	18	(	(	PUNCT
admet-2961	41	19	cdh100bev11201	cdh100bev11201	NUM
admet-2961	41	20	,	,	PUNCT
admet-2961	41	21	1	1	NUM
admet-2961	41	22	donor	donor	NOUN
admet-2961	41	23	)	)	PUNCT
admet-2961	41	24	,	,	PUNCT
admet-2961	41	25	male	male	ADJ
admet-2961	41	26	cynomolgus	cynomolgus	ADJ
admet-2961	41	27	monkeys	monkey	NOUN
admet-2961	41	28	(	(	PUNCT
admet-2961	41	29	23d008	23d008	NOUN
admet-2961	41	30	,	,	PUNCT
admet-2961	41	31	1	1	NUM
admet-2961	41	32	donor	donor	NOUN
admet-2961	41	33	)	)	PUNCT
admet-2961	41	34	,	,	PUNCT
admet-2961	41	35	and	and	CCONJ
admet-2961	41	36	male	male	ADJ
admet-2961	41	37	caucasians	caucasian	NOUN
admet-2961	41	38	(	(	PUNCT
admet-2961	41	39	005	005	NUM
admet-2961	41	40	,	,	PUNCT
admet-2961	41	41	1	1	NUM
admet-2961	41	42	donor	donor	NOUN
admet-2961	41	43	)	)	PUNCT
admet-2961	41	44	were	be	AUX
admet-2961	41	45	sourced	source	VERB
admet-2961	41	46	from	from	ADP
admet-2961	41	47	biopredict	biopredict	PROPN
admet-2961	41	48	,	,	PUNCT
admet-2961	41	49	tpcs	tpcs	PROPN
admet-2961	41	50	,	,	PUNCT
admet-2961	41	51	iphase	iphase	NOUN
admet-2961	41	52	,	,	PUNCT
admet-2961	41	53	and	and	CCONJ
admet-2961	41	54	xenotech	xenotech	PROPN
admet-2961	41	55	,	,	PUNCT
admet-2961	41	56	respectively	respectively	ADV
admet-2961	41	57	.	.	PUNCT
admet-2961	42	1	the	the	DET
admet-2961	42	2	kit	kit	NOUN
admet-2961	42	3	of	of	ADP
admet-2961	42	4	celltiter	celltiter	NOUN
admet-2961	42	5	-	-	PUNCT
admet-2961	42	6	glo	glo	NOUN
admet-2961	42	7	®	®	NOUN
admet-2961	42	8	luminescent	luminescent	NOUN
admet-2961	42	9	cell	cell	NOUN
admet-2961	42	10	viability	viability	NOUN
admet-2961	42	11	assay	assay	NOUN
admet-2961	42	12	(	(	PUNCT
admet-2961	42	13	lot	lot	NOUN
admet-2961	42	14	#	#	NOUN
admet-2961	42	15	:	:	PUNCT
admet-2961	42	16	0000582333	0000582333	NUM
admet-2961	42	17	)	)	PUNCT
admet-2961	42	18	was	be	AUX
admet-2961	42	19	purchased	purchase	VERB
admet-2961	42	20	from	from	ADP
admet-2961	42	21	promega	promega	PROPN
admet-2961	42	22	.	.	PUNCT
admet-2961	43	1	recombinant	recombinant	ADJ
admet-2961	43	2	enzymes	enzyme	NOUN
admet-2961	43	3	,	,	PUNCT
admet-2961	43	4	including	include	VERB
admet-2961	43	5	cyp1a2	cyp1a2	NOUN
admet-2961	43	6	(	(	PUNCT
admet-2961	43	7	lot	lot	NOUN
admet-2961	43	8	#	#	NOUN
admet-2961	43	9	:	:	PUNCT
admet-2961	43	10	c1a2r015a	c1a2r015a	NUM
admet-2961	43	11	)	)	PUNCT
admet-2961	43	12	,	,	PUNCT
admet-2961	43	13	cyp2d6	cyp2d6	NOUN
admet-2961	43	14	(	(	PUNCT
admet-2961	43	15	lot	lot	NOUN
admet-2961	43	16	#	#	NOUN
admet-2961	43	17	:	:	PUNCT
admet-2961	43	18	c2d6r040	c2d6r040	NOUN
admet-2961	43	19	)	)	PUNCT
admet-2961	43	20	,	,	PUNCT
admet-2961	43	21	cyp2c9	cyp2c9	INTJ
admet-2961	43	22	(	(	PUNCT
admet-2961	43	23	lot	lot	NOUN
admet-2961	43	24	#	#	NOUN
admet-2961	43	25	:	:	PUNCT
admet-2961	43	26	c2c9br014	c2c9br014	NOUN
admet-2961	43	27	)	)	PUNCT
admet-2961	43	28	,	,	PUNCT
admet-2961	43	29	cyp2c19	cyp2c19	NOUN
admet-2961	43	30	(	(	PUNCT
admet-2961	43	31	lot	lot	NOUN
admet-2961	43	32	#	#	NOUN
admet-2961	43	33	:	:	PUNCT
admet-2961	43	34	c2c19br027	c2c19br027	PROPN
admet-2961	43	35	)	)	PUNCT
admet-2961	43	36	,	,	PUNCT
admet-2961	43	37	cyp3a4	cyp3a4	NOUN
admet-2961	43	38	(	(	PUNCT
admet-2961	43	39	lot	lot	NOUN
admet-2961	43	40	#	#	NOUN
admet-2961	43	41	:	:	PUNCT
admet-2961	43	42	c3a4br054	c3a4br054	PROPN
admet-2961	43	43	)	)	PUNCT
admet-2961	43	44	,	,	PUNCT
admet-2961	43	45	cyp2b6	cyp2b6	NOUN
admet-2961	43	46	(	(	PUNCT
admet-2961	43	47	lot	lot	NOUN
admet-2961	43	48	#	#	NOUN
admet-2961	43	49	:	:	PUNCT
admet-2961	43	50	c2b6br057	c2b6br057	NOUN
admet-2961	43	51	)	)	PUNCT
admet-2961	43	52	,	,	PUNCT
admet-2961	43	53	and	and	CCONJ
admet-2961	43	54	cyp2c8	cyp2c8	ADV
admet-2961	43	55	(	(	PUNCT
admet-2961	43	56	lot	lot	NOUN
admet-2961	43	57	#	#	NOUN
admet-2961	43	58	:	:	PUNCT
admet-2961	43	59	c2c8br008a	c2c8br008a	NOUN
admet-2961	43	60	)	)	PUNCT
admet-2961	43	61	,	,	PUNCT
admet-2961	43	62	were	be	AUX
admet-2961	43	63	acquired	acquire	VERB
admet-2961	43	64	from	from	ADP
admet-2961	43	65	cypex	cypex	NOUN
admet-2961	43	66	for	for	ADP
admet-2961	43	67	enzymatic	enzymatic	ADJ
admet-2961	43	68	activity	activity	NOUN
admet-2961	43	69	studies	study	NOUN
admet-2961	43	70	.	.	PUNCT
admet-2961	44	1	48	48	NUM
admet-2961	44	2	-	-	PUNCT
admet-2961	44	3	well	well	NOUN
admet-2961	44	4	(	(	PUNCT
admet-2961	44	5	lot	lot	NOUN
admet-2961	44	6	#	#	NOUN
admet-2961	44	7	:	:	PUNCT
admet-2961	44	8	11520012	11520012	NUM
admet-2961	44	9	)	)	PUNCT
admet-2961	44	10	and	and	CCONJ
admet-2961	44	11	96	96	NUM
admet-2961	44	12	-	-	PUNCT
admet-2961	44	13	well	well	NOUN
admet-2961	44	14	(	(	PUNCT
admet-2961	44	15	lot	lot	NOUN
admet-2961	44	16	#	#	NOUN
admet-2961	44	17	:	:	PUNCT
admet-2961	44	18	31219012	31219012	NUM
admet-2961	44	19	)	)	PUNCT
admet-2961	44	20	collagen	collagen	NOUN
admet-2961	44	21	i	i	NOUN
admet-2961	44	22	-	-	PUNCT
admet-2961	44	23	precoated	precoate	VERB
admet-2961	44	24	plates	plate	NOUN
admet-2961	44	25	were	be	AUX
admet-2961	44	26	purchased	purchase	VERB
admet-2961	44	27	from	from	ADP
admet-2961	44	28	corning	corn	VERB
admet-2961	44	29	.	.	PUNCT
admet-2961	45	1	admet	admet	PROPN
admet-2961	45	2	&	&	CCONJ
admet-2961	45	3	dmpk	dmpk	PROPN
admet-2961	45	4	16(5	16(5	NUM
admet-2961	45	5	)	)	PUNCT
admet-2961	45	6	(	(	PUNCT
admet-2961	45	7	2025	2025	NUM
admet-2961	45	8	)	)	PUNCT
admet-2961	45	9	2961	2961	NUM
admet-2961	45	10	natural	natural	ADJ
admet-2961	45	11	molecules	molecule	NOUN
admet-2961	45	12	for	for	ADP
admet-2961	45	13	emt	emt	PROPN
admet-2961	45	14	treatment	treatment	NOUN
admet-2961	45	15	doi	doi	NOUN
admet-2961	45	16	:	:	PUNCT
admet-2961	45	17	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	ADJ
admet-2961	45	18	3	3	NUM
admet-2961	45	19	plateable	plateable	ADJ
admet-2961	45	20	hepatocytes	hepatocyte	NOUN
admet-2961	45	21	cytotoxicity	cytotoxicity	NOUN
admet-2961	45	22	cryopreserved	cryopreserve	VERB
admet-2961	45	23	plateable	plateable	ADJ
admet-2961	45	24	rat	rat	NOUN
admet-2961	45	25	and	and	CCONJ
admet-2961	45	26	human	human	ADJ
admet-2961	45	27	hepatocytes	hepatocyte	NOUN
admet-2961	45	28	were	be	AUX
admet-2961	45	29	thawed	thaw	VERB
admet-2961	45	30	by	by	ADP
admet-2961	45	31	immersing	immerse	VERB
admet-2961	45	32	vials	vial	NOUN
admet-2961	45	33	in	in	ADP
admet-2961	45	34	a	a	DET
admet-2961	45	35	pre	pre	NOUN
admet-2961	45	36	-	-	VERB
admet-2961	45	37	warmed	warm	VERB
admet-2961	45	38	37	37	NUM
admet-2961	45	39	°	°	PROPN
admet-2961	45	40	c	c	NOUN
admet-2961	45	41	water	water	NOUN
admet-2961	45	42	bath	bath	NOUN
admet-2961	45	43	.	.	PUNCT
admet-2961	46	1	the	the	DET
admet-2961	46	2	cell	cell	NOUN
admet-2961	46	3	pellets	pellet	NOUN
admet-2961	46	4	were	be	AUX
admet-2961	46	5	then	then	ADV
admet-2961	46	6	transferred	transfer	VERB
admet-2961	46	7	to	to	ADP
admet-2961	46	8	thawing	thaw	VERB
admet-2961	46	9	medium	medium	NOUN
admet-2961	46	10	and	and	CCONJ
admet-2961	46	11	centrifuged	centrifuge	VERB
admet-2961	46	12	to	to	PART
admet-2961	46	13	isolate	isolate	VERB
admet-2961	46	14	viable	viable	ADJ
admet-2961	46	15	cells	cell	NOUN
admet-2961	46	16	.	.	PUNCT
admet-2961	47	1	then	then	ADV
admet-2961	47	2	,	,	PUNCT
admet-2961	47	3	hepatocytes	hepatocyte	NOUN
admet-2961	47	4	were	be	AUX
admet-2961	47	5	diluted	dilute	VERB
admet-2961	47	6	to	to	ADP
admet-2961	47	7	0.1	0.1	NUM
admet-2961	47	8	million	million	NUM
admet-2961	47	9	cells	cell	NOUN
admet-2961	47	10	ml-1	ml-1	PUNCT
admet-2961	47	11	and	and	CCONJ
admet-2961	47	12	seeded	seed	VERB
admet-2961	47	13	into	into	ADP
admet-2961	47	14	96	96	NUM
admet-2961	47	15	-	-	PUNCT
admet-2961	47	16	well	well	NOUN
admet-2961	47	17	plates	plate	NOUN
admet-2961	47	18	(	(	PUNCT
admet-2961	47	19	0.1	0.1	NUM
admet-2961	47	20	ml	ml	NOUN
admet-2961	47	21	per	per	ADP
admet-2961	47	22	well	well	ADV
admet-2961	47	23	)	)	PUNCT
admet-2961	47	24	in	in	ADP
admet-2961	47	25	triplicate	triplicate	NOUN
admet-2961	47	26	.	.	PUNCT
admet-2961	48	1	after	after	ADP
admet-2961	48	2	6	6	NUM
admet-2961	48	3	hours	hour	NOUN
admet-2961	48	4	of	of	ADP
admet-2961	48	5	attachment	attachment	NOUN
admet-2961	48	6	,	,	PUNCT
admet-2961	48	7	the	the	DET
admet-2961	48	8	plating	plating	NOUN
admet-2961	48	9	medium	medium	NOUN
admet-2961	48	10	was	be	AUX
admet-2961	48	11	replaced	replace	VERB
admet-2961	48	12	with	with	ADP
admet-2961	48	13	incubation	incubation	NOUN
admet-2961	48	14	medium	medium	NOUN
admet-2961	48	15	containing	contain	VERB
admet-2961	48	16	1	1	NUM
admet-2961	48	17	%	%	NOUN
admet-2961	48	18	matrigel	matrigel	NOUN
admet-2961	48	19	™	™	PROPN
admet-2961	48	20	.	.	PUNCT
admet-2961	49	1	on	on	ADP
admet-2961	49	2	the	the	DET
admet-2961	49	3	following	following	ADJ
admet-2961	49	4	day	day	NOUN
admet-2961	49	5	,	,	PUNCT
admet-2961	49	6	the	the	DET
admet-2961	49	7	cell	cell	NOUN
admet-2961	49	8	medium	medium	NOUN
admet-2961	49	9	was	be	AUX
admet-2961	49	10	replaced	replace	VERB
admet-2961	49	11	with	with	ADP
admet-2961	49	12	a	a	DET
admet-2961	49	13	series	series	NOUN
admet-2961	49	14	of	of	ADP
admet-2961	49	15	metoprolol	metoprolol	PROPN
admet-2961	49	16	dosing	dose	VERB
admet-2961	49	17	solutions	solution	NOUN
admet-2961	49	18	(	(	PUNCT
admet-2961	49	19	0	0	NUM
admet-2961	49	20	,	,	PUNCT
admet-2961	49	21	100	100	NUM
admet-2961	49	22	,	,	PUNCT
admet-2961	49	23	150	150	NUM
admet-2961	49	24	,	,	PUNCT
admet-2961	49	25	200	200	NUM
admet-2961	49	26	,	,	PUNCT
admet-2961	49	27	250	250	NUM
admet-2961	49	28	and	and	CCONJ
admet-2961	49	29	500	500	NUM
admet-2961	49	30	µm	µm	NOUN
admet-2961	49	31	)	)	PUNCT
admet-2961	49	32	in	in	ADP
admet-2961	49	33	the	the	DET
admet-2961	49	34	presence	presence	NOUN
admet-2961	49	35	or	or	CCONJ
admet-2961	49	36	absence	absence	NOUN
admet-2961	49	37	of	of	ADP
admet-2961	49	38	50	50	NUM
admet-2961	49	39	µm	µm	SYM
admet-2961	49	40	1	1	NUM
admet-2961	49	41	-	-	NOUN
admet-2961	49	42	aminobenzotriazole	aminobenzotriazole	NOUN
admet-2961	49	43	(	(	PUNCT
admet-2961	49	44	abt	abt	INTJ
admet-2961	49	45	)	)	PUNCT
admet-2961	49	46	,	,	PUNCT
admet-2961	49	47	a	a	DET
admet-2961	49	48	cytochrome	cytochrome	ADJ
admet-2961	49	49	p450	p450	NUM
admet-2961	49	50	inhibitor	inhibitor	NOUN
admet-2961	49	51	,	,	PUNCT
admet-2961	49	52	and	and	CCONJ
admet-2961	49	53	then	then	ADV
admet-2961	49	54	the	the	DET
admet-2961	49	55	hepatocyte	hepatocyte	NOUN
admet-2961	49	56	cytotoxicity	cytotoxicity	NOUN
admet-2961	49	57	was	be	AUX
admet-2961	49	58	determined	determine	VERB
admet-2961	49	59	using	use	VERB
admet-2961	49	60	a	a	DET
admet-2961	49	61	commercially	commercially	ADV
admet-2961	49	62	available	available	ADJ
admet-2961	49	63	atp	atp	NOUN
admet-2961	49	64	detection	detection	NOUN
admet-2961	49	65	assay	assay	NOUN
admet-2961	49	66	(	(	PUNCT
admet-2961	49	67	celltiter	celltiter	NOUN
admet-2961	49	68	-	-	PUNCT
admet-2961	49	69	glo	glo	NOUN
admet-2961	49	70	®	®	NOUN
admet-2961	49	71	)	)	PUNCT
admet-2961	49	72	.	.	PUNCT
admet-2961	50	1	prior	prior	ADV
admet-2961	50	2	to	to	ADP
admet-2961	50	3	the	the	DET
admet-2961	50	4	measurement	measurement	NOUN
admet-2961	50	5	,	,	PUNCT
admet-2961	50	6	the	the	DET
admet-2961	50	7	cell	cell	NOUN
admet-2961	50	8	culture	culture	NOUN
admet-2961	50	9	plate	plate	NOUN
admet-2961	50	10	was	be	AUX
admet-2961	50	11	equilibrated	equilibrate	VERB
admet-2961	50	12	to	to	ADP
admet-2961	50	13	ambient	ambient	ADJ
admet-2961	50	14	temperature	temperature	NOUN
admet-2961	50	15	.	.	PUNCT
admet-2961	51	1	subsequently	subsequently	ADV
admet-2961	51	2	,	,	PUNCT
admet-2961	51	3	100	100	NUM
admet-2961	51	4	μl	μl	ADP
admet-2961	51	5	of	of	ADP
admet-2961	51	6	celltiter	celltiter	NOUN
admet-2961	51	7	-	-	PUNCT
admet-2961	51	8	glo	glo	NOUN
admet-2961	51	9	®	®	NOUN
admet-2961	51	10	reagent	reagent	NOUN
admet-2961	51	11	was	be	AUX
admet-2961	51	12	dispensed	dispense	VERB
admet-2961	51	13	into	into	ADP
admet-2961	51	14	each	each	PRON
admet-2961	51	15	well	well	ADV
admet-2961	51	16	,	,	PUNCT
admet-2961	51	17	followed	follow	VERB
admet-2961	51	18	by	by	ADP
admet-2961	51	19	orbital	orbital	ADJ
admet-2961	51	20	shaking	shaking	NOUN
admet-2961	51	21	(	(	PUNCT
admet-2961	51	22	5	5	NUM
admet-2961	51	23	min	min	NOUN
admet-2961	51	24	)	)	PUNCT
admet-2961	51	25	to	to	PART
admet-2961	51	26	ensure	ensure	VERB
admet-2961	51	27	complete	complete	ADJ
admet-2961	51	28	cell	cell	NOUN
admet-2961	51	29	lysis	lysis	NOUN
admet-2961	51	30	.	.	PUNCT
admet-2961	52	1	after	after	ADP
admet-2961	52	2	a	a	DET
admet-2961	52	3	10	10	NUM
admet-2961	52	4	-	-	PUNCT
admet-2961	52	5	minute	minute	NOUN
admet-2961	52	6	stabilization	stabilization	NOUN
admet-2961	52	7	at	at	ADP
admet-2961	52	8	room	room	NOUN
admet-2961	52	9	temperature	temperature	NOUN
admet-2961	52	10	,	,	PUNCT
admet-2961	52	11	luminescence	luminescence	NOUN
admet-2961	52	12	signals	signal	NOUN
admet-2961	52	13	were	be	AUX
admet-2961	52	14	quantified	quantify	VERB
admet-2961	52	15	using	use	VERB
admet-2961	52	16	an	an	DET
admet-2961	52	17	envision	envision	NOUN
admet-2961	52	18	®	®	NOUN
admet-2961	52	19	multilabel	multilabel	NOUN
admet-2961	52	20	plate	plate	NOUN
admet-2961	52	21	reader	reader	NOUN
admet-2961	52	22	.	.	PUNCT
admet-2961	53	1	plateable	plateable	ADJ
admet-2961	53	2	hepatocytes	hepatocytes	PROPN
admet-2961	53	3	stability	stability	NOUN
admet-2961	53	4	cryopreserved	cryopreserve	VERB
admet-2961	53	5	human	human	ADJ
admet-2961	53	6	hepatocytes	hepatocyte	NOUN
admet-2961	53	7	were	be	AUX
admet-2961	53	8	thawed	thaw	VERB
admet-2961	53	9	by	by	ADP
admet-2961	53	10	immersing	immerse	VERB
admet-2961	53	11	vials	vial	NOUN
admet-2961	53	12	in	in	ADP
admet-2961	53	13	a	a	DET
admet-2961	53	14	pre	pre	NOUN
admet-2961	53	15	-	-	VERB
admet-2961	53	16	warmed	warm	VERB
admet-2961	53	17	37	37	NUM
admet-2961	53	18	°	°	PROPN
admet-2961	53	19	c	c	NOUN
admet-2961	53	20	water	water	NOUN
admet-2961	53	21	bath	bath	NOUN
admet-2961	53	22	.	.	PUNCT
admet-2961	54	1	the	the	DET
admet-2961	54	2	cell	cell	NOUN
admet-2961	54	3	pellets	pellet	NOUN
admet-2961	54	4	were	be	AUX
admet-2961	54	5	then	then	ADV
admet-2961	54	6	transferred	transfer	VERB
admet-2961	54	7	to	to	ADP
admet-2961	54	8	thawing	thaw	VERB
admet-2961	54	9	medium	medium	NOUN
admet-2961	54	10	and	and	CCONJ
admet-2961	54	11	centrifuged	centrifuge	VERB
admet-2961	54	12	to	to	PART
admet-2961	54	13	isolate	isolate	VERB
admet-2961	54	14	viable	viable	ADJ
admet-2961	54	15	cells	cell	NOUN
admet-2961	54	16	.	.	PUNCT
admet-2961	55	1	then	then	ADV
admet-2961	55	2	,	,	PUNCT
admet-2961	55	3	hepatocytes	hepatocyte	NOUN
admet-2961	55	4	were	be	AUX
admet-2961	55	5	diluted	dilute	VERB
admet-2961	55	6	to	to	ADP
admet-2961	55	7	0.7	0.7	NUM
admet-2961	55	8	million	million	NUM
admet-2961	55	9	cells	cell	NOUN
admet-2961	55	10	ml-1	ml-1	PUNCT
admet-2961	55	11	and	and	CCONJ
admet-2961	55	12	seeded	seed	VERB
admet-2961	55	13	into	into	ADP
admet-2961	55	14	collagen	collagen	NOUN
admet-2961	55	15	-	-	PUNCT
admet-2961	55	16	coated	coat	VERB
admet-2961	55	17	48	48	NUM
admet-2961	55	18	-	-	PUNCT
admet-2961	55	19	well	well	NOUN
admet-2961	55	20	plates	plate	NOUN
admet-2961	55	21	(	(	PUNCT
admet-2961	55	22	0.2	0.2	NUM
admet-2961	55	23	ml	ml	NOUN
admet-2961	55	24	per	per	ADP
admet-2961	55	25	well	well	ADV
admet-2961	55	26	)	)	PUNCT
admet-2961	55	27	in	in	ADP
admet-2961	55	28	triplicate	triplicate	NOUN
admet-2961	55	29	.	.	PUNCT
admet-2961	56	1	after	after	ADP
admet-2961	56	2	6	6	NUM
admet-2961	56	3	hours	hour	NOUN
admet-2961	56	4	of	of	ADP
admet-2961	56	5	attachment	attachment	NOUN
admet-2961	56	6	,	,	PUNCT
admet-2961	56	7	the	the	DET
admet-2961	56	8	plating	plating	NOUN
admet-2961	56	9	medium	medium	NOUN
admet-2961	56	10	was	be	AUX
admet-2961	56	11	replaced	replace	VERB
admet-2961	56	12	with	with	ADP
admet-2961	56	13	incubation	incubation	NOUN
admet-2961	56	14	medium	medium	NOUN
admet-2961	56	15	containing	contain	VERB
admet-2961	56	16	1	1	NUM
admet-2961	56	17	%	%	NOUN
admet-2961	56	18	matrigel	matrigel	NOUN
admet-2961	56	19	™	™	PROPN
admet-2961	56	20	.	.	PUNCT
admet-2961	57	1	on	on	ADP
admet-2961	57	2	the	the	DET
admet-2961	57	3	following	following	ADJ
admet-2961	57	4	day	day	NOUN
admet-2961	57	5	,	,	PUNCT
admet-2961	57	6	the	the	DET
admet-2961	57	7	medium	medium	NOUN
admet-2961	57	8	was	be	AUX
admet-2961	57	9	replaced	replace	VERB
admet-2961	57	10	with	with	ADP
admet-2961	57	11	a	a	DET
admet-2961	57	12	dosing	dose	VERB
admet-2961	57	13	solution	solution	NOUN
admet-2961	57	14	containing	contain	VERB
admet-2961	57	15	1	1	NUM
admet-2961	57	16	µm	µm	ADP
admet-2961	57	17	metoprolol	metoprolol	NOUN
admet-2961	57	18	to	to	PART
admet-2961	57	19	initiate	initiate	VERB
admet-2961	57	20	metabolic	metabolic	NOUN
admet-2961	57	21	reactions	reaction	NOUN
admet-2961	57	22	.	.	PUNCT
admet-2961	58	1	aliquots	aliquot	NOUN
admet-2961	58	2	were	be	AUX
admet-2961	58	3	collected	collect	VERB
admet-2961	58	4	at	at	ADP
admet-2961	58	5	0	0	NUM
admet-2961	58	6	,	,	PUNCT
admet-2961	58	7	2	2	NUM
admet-2961	58	8	,	,	PUNCT
admet-2961	58	9	4	4	NUM
admet-2961	58	10	,	,	PUNCT
admet-2961	58	11	8	8	NUM
admet-2961	58	12	,	,	PUNCT
admet-2961	58	13	24	24	NUM
admet-2961	58	14	,	,	PUNCT
admet-2961	58	15	48	48	NUM
admet-2961	58	16	and	and	CCONJ
admet-2961	58	17	72	72	NUM
admet-2961	58	18	hours	hour	NOUN
admet-2961	58	19	,	,	PUNCT
admet-2961	58	20	and	and	CCONJ
admet-2961	58	21	reactions	reaction	NOUN
admet-2961	58	22	were	be	AUX
admet-2961	58	23	quenched	quench	VERB
admet-2961	58	24	with	with	ADP
admet-2961	58	25	cold	cold	ADJ
admet-2961	58	26	acetonitrile	acetonitrile	NOUN
admet-2961	58	27	/	/	SYM
admet-2961	58	28	methanol	methanol	NOUN
admet-2961	58	29	(	(	PUNCT
admet-2961	58	30	1:1	1:1	NUM
admet-2961	58	31	,	,	PUNCT
admet-2961	58	32	v	v	NOUN
admet-2961	58	33	/	/	SYM
admet-2961	58	34	v	v	NOUN
admet-2961	58	35	)	)	PUNCT
admet-2961	58	36	containing	contain	VERB
admet-2961	58	37	labetalol	labetalol	NOUN
admet-2961	58	38	(	(	PUNCT
admet-2961	58	39	100	100	NUM
admet-2961	58	40	ng	ng	PROPN
admet-2961	58	41	ml-1	ml-1	NUM
admet-2961	58	42	)	)	PUNCT
admet-2961	58	43	.	.	PUNCT
admet-2961	59	1	after	after	ADP
admet-2961	59	2	centrifugation	centrifugation	NOUN
admet-2961	59	3	(	(	PUNCT
admet-2961	59	4	12,000	12,000	NUM
admet-2961	59	5	g	g	NOUN
admet-2961	59	6	,	,	PUNCT
admet-2961	59	7	15	15	NUM
admet-2961	59	8	min	min	NOUN
admet-2961	59	9	,	,	PUNCT
admet-2961	59	10	4	4	NUM
admet-2961	59	11	°	°	NOUN
admet-2961	59	12	c	c	NOUN
admet-2961	59	13	)	)	PUNCT
admet-2961	59	14	,	,	PUNCT
admet-2961	59	15	supernatants	supernatant	NOUN
admet-2961	59	16	were	be	AUX
admet-2961	59	17	analysed	analyse	VERB
admet-2961	59	18	via	via	ADP
admet-2961	59	19	lc-30ad	lc-30ad	NOUN
admet-2961	59	20	-	-	PUNCT
admet-2961	59	21	api5500	api5500	NOUN
admet-2961	59	22	(	(	PUNCT
admet-2961	59	23	lc	lc	PROPN
admet-2961	59	24	-	-	PUNCT
admet-2961	59	25	ms	ms	PROPN
admet-2961	59	26	/	/	SYM
admet-2961	59	27	ms	ms	PROPN
admet-2961	59	28	,	,	PUNCT
admet-2961	59	29	sciex	sciex	NOUN
admet-2961	59	30	,	,	PUNCT
admet-2961	59	31	usa	usa	PROPN
admet-2961	59	32	)	)	PUNCT
admet-2961	59	33	for	for	ADP
admet-2961	59	34	semiquantitative	semiquantitative	ADJ
admet-2961	59	35	assessment	assessment	NOUN
admet-2961	59	36	.	.	PUNCT
admet-2961	60	1	recombinant	recombinant	ADJ
admet-2961	60	2	cytochrome	cytochrome	ADJ
admet-2961	60	3	p450	p450	PROPN
admet-2961	60	4	reaction	reaction	NOUN
admet-2961	60	5	phenotyping	phenotype	VERB
admet-2961	60	6	human	human	ADJ
admet-2961	60	7	recombinant	recombinant	ADJ
admet-2961	60	8	enzymes	enzyme	NOUN
admet-2961	60	9	were	be	AUX
admet-2961	60	10	diluted	dilute	VERB
admet-2961	60	11	to	to	ADP
admet-2961	60	12	50	50	NUM
admet-2961	60	13	pmol	pmol	NOUN
admet-2961	60	14	ml-1	ml-1	ADV
admet-2961	60	15	in	in	ADP
admet-2961	60	16	50	50	NUM
admet-2961	60	17	mm	mm	NOUN
admet-2961	60	18	phosphate	phosphate	NOUN
admet-2961	60	19	buffer	buffer	NOUN
admet-2961	60	20	.	.	PUNCT
admet-2961	61	1	metoprolol	metoprolol	PROPN
admet-2961	61	2	was	be	AUX
admet-2961	61	3	added	add	VERB
admet-2961	61	4	to	to	ADP
admet-2961	61	5	the	the	DET
admet-2961	61	6	enzyme	enzyme	NOUN
admet-2961	61	7	solution	solution	NOUN
admet-2961	61	8	(	(	PUNCT
admet-2961	61	9	final	final	ADJ
admet-2961	61	10	concentration	concentration	NOUN
admet-2961	61	11	:	:	PUNCT
admet-2961	61	12	1	1	NUM
admet-2961	61	13	µm	µm	NOUN
admet-2961	61	14	)	)	PUNCT
admet-2961	61	15	in	in	ADP
admet-2961	61	16	duplicate	duplicate	NOUN
admet-2961	61	17	and	and	CCONJ
admet-2961	61	18	preincubated	preincubate	VERB
admet-2961	61	19	for	for	ADP
admet-2961	61	20	5	5	NUM
admet-2961	61	21	min	min	NOUN
admet-2961	61	22	.	.	NOUN
admet-2961	61	23	reactions	reaction	NOUN
admet-2961	61	24	were	be	AUX
admet-2961	61	25	initiated	initiate	VERB
admet-2961	61	26	by	by	ADP
admet-2961	61	27	adding	add	VERB
admet-2961	61	28	nadph	nadph	ADJ
admet-2961	61	29	(	(	PUNCT
admet-2961	61	30	final	final	ADJ
admet-2961	61	31	concentration	concentration	NOUN
admet-2961	61	32	:	:	PUNCT
admet-2961	61	33	1	1	NUM
admet-2961	61	34	mm	mm	NOUN
admet-2961	61	35	)	)	PUNCT
admet-2961	61	36	and	and	CCONJ
admet-2961	61	37	aliquots	aliquot	NOUN
admet-2961	61	38	were	be	AUX
admet-2961	61	39	collected	collect	VERB
admet-2961	61	40	at	at	ADP
admet-2961	61	41	0	0	NUM
admet-2961	61	42	,	,	PUNCT
admet-2961	61	43	15	15	NUM
admet-2961	61	44	,	,	PUNCT
admet-2961	61	45	30	30	NUM
admet-2961	61	46	,	,	PUNCT
admet-2961	61	47	60	60	NUM
admet-2961	61	48	and	and	CCONJ
admet-2961	61	49	120	120	NUM
admet-2961	61	50	min	min	NOUN
admet-2961	61	51	.	.	NOUN
admet-2961	61	52	samples	sample	NOUN
admet-2961	61	53	were	be	AUX
admet-2961	61	54	quenched	quench	VERB
admet-2961	61	55	with	with	ADP
admet-2961	61	56	cold	cold	ADJ
admet-2961	61	57	acetonitrile	acetonitrile	NOUN
admet-2961	61	58	containing	contain	VERB
admet-2961	61	59	tolbutamide	tolbutamide	NOUN
admet-2961	61	60	(	(	PUNCT
admet-2961	61	61	10	10	NUM
admet-2961	61	62	ng	ng	PROPN
admet-2961	61	63	/	/	SYM
admet-2961	61	64	ml	ml	PROPN
admet-2961	61	65	)	)	PUNCT
admet-2961	61	66	,	,	PUNCT
admet-2961	61	67	centrifuged	centrifuge	VERB
admet-2961	61	68	(	(	PUNCT
admet-2961	61	69	12,000	12,000	NUM
admet-2961	61	70	g	g	NOUN
admet-2961	61	71	,	,	PUNCT
admet-2961	61	72	15	15	NUM
admet-2961	61	73	min	min	NOUN
admet-2961	61	74	,	,	PUNCT
admet-2961	61	75	4	4	NUM
admet-2961	61	76	°	°	NOUN
admet-2961	61	77	c	c	NOUN
admet-2961	61	78	)	)	PUNCT
admet-2961	61	79	and	and	CCONJ
admet-2961	61	80	analysed	analyse	VERB
admet-2961	61	81	by	by	ADP
admet-2961	61	82	lc	lc	PROPN
admet-2961	61	83	-	-	PUNCT
admet-2961	61	84	ms	ms	PROPN
admet-2961	61	85	/	/	SYM
admet-2961	61	86	ms	ms	PROPN
admet-2961	61	87	.	.	PROPN
admet-2961	61	88	for	for	ADP
admet-2961	61	89	qualitative	qualitative	ADJ
admet-2961	61	90	metabolite	metabolite	NOUN
admet-2961	61	91	analysis	analysis	NOUN
admet-2961	61	92	,	,	PUNCT
admet-2961	61	93	0and	0and	ADJ
admet-2961	61	94	60	60	NUM
admet-2961	61	95	-	-	PUNCT
admet-2961	61	96	minute	minute	NOUN
admet-2961	61	97	samples	sample	NOUN
admet-2961	61	98	were	be	AUX
admet-2961	61	99	dried	dry	VERB
admet-2961	61	100	,	,	PUNCT
admet-2961	61	101	reconstituted	reconstitute	VERB
admet-2961	61	102	,	,	PUNCT
admet-2961	61	103	centrifuged	centrifuge	VERB
admet-2961	61	104	(	(	PUNCT
admet-2961	61	105	12,000	12,000	NUM
admet-2961	61	106	g	g	NOUN
admet-2961	61	107	,	,	PUNCT
admet-2961	61	108	15	15	NUM
admet-2961	61	109	min	min	NOUN
admet-2961	61	110	,	,	PUNCT
admet-2961	61	111	4	4	NUM
admet-2961	61	112	°	°	NOUN
admet-2961	61	113	c	c	NOUN
admet-2961	61	114	)	)	PUNCT
admet-2961	61	115	and	and	CCONJ
admet-2961	61	116	analysed	analyse	VERB
admet-2961	61	117	on	on	ADP
admet-2961	61	118	ultimate	ultimate	ADJ
admet-2961	61	119	3000	3000	NUM
admet-2961	61	120	-	-	PUNCT
admet-2961	61	121	qexactive	qexactive	ADJ
admet-2961	61	122	plus	plus	CCONJ
admet-2961	61	123	(	(	PUNCT
admet-2961	61	124	lc	lc	NOUN
admet-2961	61	125	-	-	PUNCT
admet-2961	61	126	hrms	hrm	NOUN
admet-2961	61	127	,	,	PUNCT
admet-2961	61	128	thermofisher	thermofisher	PROPN
admet-2961	61	129	,	,	PUNCT
admet-2961	61	130	germany	germany	PROPN
admet-2961	61	131	)	)	PUNCT
admet-2961	61	132	.	.	PUNCT
admet-2961	62	1	metabolite	metabolite	NOUN
admet-2961	62	2	identification	identification	NOUN
admet-2961	62	3	in	in	ADP
admet-2961	62	4	recombinant	recombinant	ADJ
admet-2961	62	5	cytochrome	cytochrome	ADJ
admet-2961	62	6	2d6	2d6	NUM
admet-2961	62	7	enzymes	enzyme	NOUN
admet-2961	62	8	and	and	CCONJ
admet-2961	62	9	plateable	plateable	ADJ
admet-2961	62	10	hepatocytes	hepatocyte	NOUN
admet-2961	62	11	human	human	ADJ
admet-2961	62	12	recombinant	recombinant	ADJ
admet-2961	62	13	cytochrome	cytochrome	NOUN
admet-2961	62	14	2d6	2d6	NUM
admet-2961	62	15	enzymes	enzyme	NOUN
admet-2961	62	16	were	be	AUX
admet-2961	62	17	diluted	dilute	VERB
admet-2961	62	18	to	to	ADP
admet-2961	62	19	50	50	NUM
admet-2961	62	20	pmol	pmol	NOUN
admet-2961	62	21	ml-1	ml-1	ADV
admet-2961	62	22	in	in	ADP
admet-2961	62	23	50	50	NUM
admet-2961	62	24	mm	mm	NOUN
admet-2961	62	25	phosphate	phosphate	NOUN
admet-2961	62	26	buffer	buffer	NOUN
admet-2961	62	27	.	.	PUNCT
admet-2961	63	1	metoprolol	metoprolol	PROPN
admet-2961	63	2	was	be	AUX
admet-2961	63	3	added	add	VERB
admet-2961	63	4	to	to	ADP
admet-2961	63	5	the	the	DET
admet-2961	63	6	enzyme	enzyme	NOUN
admet-2961	63	7	solution	solution	NOUN
admet-2961	63	8	(	(	PUNCT
admet-2961	63	9	final	final	ADJ
admet-2961	63	10	concentration	concentration	NOUN
admet-2961	63	11	:	:	PUNCT
admet-2961	63	12	1	1	NUM
admet-2961	63	13	µm	µm	NOUN
admet-2961	63	14	)	)	PUNCT
admet-2961	63	15	in	in	ADP
admet-2961	63	16	duplicate	duplicate	NOUN
admet-2961	63	17	and	and	CCONJ
admet-2961	63	18	preincubated	preincubate	VERB
admet-2961	63	19	for	for	ADP
admet-2961	63	20	5	5	NUM
admet-2961	63	21	min	min	NOUN
admet-2961	63	22	.	.	NOUN
admet-2961	63	23	reactions	reaction	NOUN
admet-2961	63	24	were	be	AUX
admet-2961	63	25	initiated	initiate	VERB
admet-2961	63	26	by	by	ADP
admet-2961	63	27	adding	add	VERB
admet-2961	63	28	nadph	nadph	ADJ
admet-2961	63	29	(	(	PUNCT
admet-2961	63	30	final	final	ADJ
admet-2961	63	31	concentration	concentration	NOUN
admet-2961	63	32	:	:	PUNCT
admet-2961	63	33	1	1	NUM
admet-2961	63	34	mm	mm	NOUN
admet-2961	63	35	)	)	PUNCT
admet-2961	63	36	,	,	PUNCT
admet-2961	63	37	and	and	CCONJ
admet-2961	63	38	aliquots	aliquot	NOUN
admet-2961	63	39	were	be	AUX
admet-2961	63	40	collected	collect	VERB
admet-2961	63	41	at	at	ADP
admet-2961	63	42	60	60	NUM
admet-2961	63	43	min	min	NOUN
admet-2961	63	44	.	.	NOUN
admet-2961	63	45	samples	sample	NOUN
admet-2961	63	46	were	be	AUX
admet-2961	63	47	quenched	quench	VERB
admet-2961	63	48	with	with	ADP
admet-2961	63	49	cold	cold	ADJ
admet-2961	63	50	acetonitrile	acetonitrile	NOUN
admet-2961	63	51	containing	contain	VERB
admet-2961	63	52	0.1	0.1	NUM
admet-2961	63	53	%	%	NOUN
admet-2961	63	54	formic	formic	ADJ
admet-2961	63	55	acid	acid	NOUN
admet-2961	63	56	,	,	PUNCT
admet-2961	63	57	centrifuged	centrifuge	VERB
admet-2961	63	58	(	(	PUNCT
admet-2961	63	59	12,000	12,000	NUM
admet-2961	63	60	g	g	NOUN
admet-2961	63	61	,	,	PUNCT
admet-2961	63	62	15	15	NUM
admet-2961	63	63	min	min	NOUN
admet-2961	63	64	,	,	PUNCT
admet-2961	63	65	4	4	NUM
admet-2961	63	66	°	°	NOUN
admet-2961	63	67	c	c	NOUN
admet-2961	63	68	)	)	PUNCT
admet-2961	63	69	,	,	PUNCT
admet-2961	63	70	then	then	ADV
admet-2961	63	71	supernatants	supernatant	NOUN
admet-2961	63	72	were	be	AUX
admet-2961	63	73	dried	dry	VERB
admet-2961	63	74	,	,	PUNCT
admet-2961	63	75	reconstituted	reconstitute	VERB
admet-2961	63	76	,	,	PUNCT
admet-2961	63	77	centrifuged	centrifuge	VERB
admet-2961	63	78	(	(	PUNCT
admet-2961	63	79	12,000	12,000	NUM
admet-2961	63	80	g	g	NOUN
admet-2961	63	81	,	,	PUNCT
admet-2961	63	82	15	15	NUM
admet-2961	63	83	min	min	NOUN
admet-2961	63	84	,	,	PUNCT
admet-2961	63	85	4	4	NUM
admet-2961	63	86	°	°	NOUN
admet-2961	63	87	c	c	NOUN
admet-2961	63	88	)	)	PUNCT
admet-2961	63	89	,	,	PUNCT
admet-2961	63	90	and	and	CCONJ
admet-2961	63	91	subjected	subject	VERB
admet-2961	63	92	to	to	ADP
admet-2961	63	93	an	an	DET
admet-2961	63	94	analysis	analysis	NOUN
admet-2961	63	95	on	on	ADP
admet-2961	63	96	lc	lc	NOUN
admet-2961	63	97	-	-	PUNCT
admet-2961	63	98	hrms	hrm	NOUN
admet-2961	63	99	..	..	PUNCT
admet-2961	63	100	cryopreserved	cryopreserve	VERB
admet-2961	63	101	rat	rat	NOUN
admet-2961	63	102	,	,	PUNCT
admet-2961	63	103	dog	dog	NOUN
admet-2961	63	104	,	,	PUNCT
admet-2961	63	105	monkey	monkey	NOUN
admet-2961	63	106	and	and	CCONJ
admet-2961	63	107	human	human	ADJ
admet-2961	63	108	hepatocytes	hepatocyte	NOUN
admet-2961	63	109	were	be	AUX
admet-2961	63	110	thawed	thaw	VERB
admet-2961	63	111	by	by	ADP
admet-2961	63	112	immersing	immerse	VERB
admet-2961	63	113	vials	vial	NOUN
admet-2961	63	114	in	in	ADP
admet-2961	63	115	a	a	DET
admet-2961	63	116	prewarmed	prewarmed	ADJ
admet-2961	63	117	37	37	NUM
admet-2961	63	118	°	°	NOUN
admet-2961	63	119	c	c	NOUN
admet-2961	63	120	water	water	NOUN
admet-2961	63	121	bath	bath	NOUN
admet-2961	63	122	.	.	PUNCT
admet-2961	64	1	the	the	DET
admet-2961	64	2	cell	cell	NOUN
admet-2961	64	3	pellets	pellet	NOUN
admet-2961	64	4	were	be	AUX
admet-2961	64	5	then	then	ADV
admet-2961	64	6	transferred	transfer	VERB
admet-2961	64	7	to	to	ADP
admet-2961	64	8	thawing	thaw	VERB
admet-2961	64	9	medium	medium	NOUN
admet-2961	64	10	and	and	CCONJ
admet-2961	64	11	centrifuged	centrifuge	VERB
admet-2961	64	12	to	to	PART
admet-2961	64	13	isolate	isolate	VERB
admet-2961	64	14	viable	viable	ADJ
admet-2961	64	15	cells	cell	NOUN
admet-2961	64	16	.	.	PUNCT
admet-2961	65	1	then	then	ADV
admet-2961	65	2	,	,	PUNCT
admet-2961	65	3	hepatocytes	hepatocyte	NOUN
admet-2961	65	4	were	be	AUX
admet-2961	65	5	diluted	dilute	VERB
admet-2961	65	6	to	to	ADP
admet-2961	65	7	0.7	0.7	NUM
admet-2961	65	8	million	million	NUM
admet-2961	65	9	cells	cell	NOUN
admet-2961	65	10	ml-1	ml-1	PUNCT
admet-2961	65	11	and	and	CCONJ
admet-2961	65	12	seeded	seed	VERB
admet-2961	65	13	into	into	ADP
admet-2961	65	14	collagen	collagen	NOUN
admet-2961	65	15	-	-	PUNCT
admet-2961	65	16	coated	coat	VERB
admet-2961	65	17	48	48	NUM
admet-2961	65	18	-	-	PUNCT
admet-2961	65	19	well	well	NOUN
admet-2961	65	20	plates	plate	NOUN
admet-2961	65	21	(	(	PUNCT
admet-2961	65	22	0.2	0.2	NUM
admet-2961	65	23	ml	ml	NOUN
admet-2961	65	24	per	per	ADP
admet-2961	65	25	well	well	ADV
admet-2961	65	26	)	)	PUNCT
admet-2961	65	27	in	in	ADP
admet-2961	65	28	duplicate	duplicate	NOUN
admet-2961	65	29	.	.	PUNCT
admet-2961	66	1	after	after	ADP
admet-2961	66	2	6	6	NUM
admet-2961	66	3	hours	hour	NOUN
admet-2961	66	4	of	of	ADP
admet-2961	66	5	attachment	attachment	NOUN
admet-2961	66	6	,	,	PUNCT
admet-2961	66	7	the	the	DET
admet-2961	66	8	plating	plating	NOUN
admet-2961	66	9	medium	medium	NOUN
admet-2961	66	10	was	be	AUX
admet-2961	66	11	replaced	replace	VERB
admet-2961	66	12	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	66	13	j.	j.	PROPN
admet-2961	66	14	pu	pu	PROPN
admet-2961	66	15	et	et	PROPN
admet-2961	66	16	al	al	PROPN
admet-2961	66	17	.	.	PROPN
admet-2961	66	18	admet	admet	PROPN
admet-2961	66	19	&	&	CCONJ
admet-2961	66	20	dmpk	dmpk	PROPN
admet-2961	66	21	13(5	13(5	NUM
admet-2961	66	22	)	)	PUNCT
admet-2961	66	23	(	(	PUNCT
admet-2961	66	24	2025	2025	NUM
admet-2961	66	25	)	)	PUNCT
admet-2961	66	26	2961	2961	NUM
admet-2961	66	27	4	4	NUM
admet-2961	66	28	with	with	ADP
admet-2961	66	29	incubation	incubation	NOUN
admet-2961	66	30	medium	medium	NOUN
admet-2961	66	31	containing	contain	VERB
admet-2961	66	32	1	1	NUM
admet-2961	66	33	%	%	NOUN
admet-2961	66	34	matrigel	matrigel	NOUN
admet-2961	66	35	™	™	PROPN
admet-2961	66	36	.	.	PUNCT
admet-2961	67	1	on	on	ADP
admet-2961	67	2	the	the	DET
admet-2961	67	3	following	following	ADJ
admet-2961	67	4	day	day	NOUN
admet-2961	67	5	,	,	PUNCT
admet-2961	67	6	the	the	DET
admet-2961	67	7	medium	medium	NOUN
admet-2961	67	8	was	be	AUX
admet-2961	67	9	replaced	replace	VERB
admet-2961	67	10	with	with	ADP
admet-2961	67	11	a	a	DET
admet-2961	67	12	dosing	dose	VERB
admet-2961	67	13	solution	solution	NOUN
admet-2961	67	14	containing	contain	VERB
admet-2961	67	15	10	10	NUM
admet-2961	67	16	µm	µm	ADP
admet-2961	67	17	metoprolol	metoprolol	NOUN
admet-2961	67	18	to	to	PART
admet-2961	67	19	initiate	initiate	VERB
admet-2961	67	20	metabolic	metabolic	NOUN
admet-2961	67	21	reactions	reaction	NOUN
admet-2961	67	22	.	.	PUNCT
admet-2961	68	1	reactions	reaction	NOUN
admet-2961	68	2	were	be	AUX
admet-2961	68	3	quenched	quench	VERB
admet-2961	68	4	at	at	ADP
admet-2961	68	5	72	72	NUM
admet-2961	68	6	hours	hour	NOUN
admet-2961	68	7	with	with	ADP
admet-2961	68	8	cold	cold	ADJ
admet-2961	68	9	acetonitrile	acetonitrile	NOUN
admet-2961	68	10	containing	contain	VERB
admet-2961	68	11	0.1	0.1	NUM
admet-2961	68	12	%	%	NOUN
admet-2961	68	13	formic	formic	ADJ
admet-2961	68	14	acid	acid	NOUN
admet-2961	68	15	,	,	PUNCT
admet-2961	68	16	and	and	CCONJ
admet-2961	68	17	supernatants	supernatant	NOUN
admet-2961	68	18	were	be	AUX
admet-2961	68	19	dried	dry	VERB
admet-2961	68	20	under	under	ADP
admet-2961	68	21	nitrogen	nitrogen	NOUN
admet-2961	68	22	gas	gas	NOUN
admet-2961	68	23	.	.	PUNCT
admet-2961	69	1	the	the	DET
admet-2961	69	2	residues	residue	NOUN
admet-2961	69	3	were	be	AUX
admet-2961	69	4	reconstituted	reconstitute	VERB
admet-2961	69	5	in	in	ADP
admet-2961	69	6	acetonitrile	acetonitrile	ADJ
admet-2961	69	7	/	/	SYM
admet-2961	69	8	water	water	NOUN
admet-2961	69	9	(	(	PUNCT
admet-2961	69	10	1:9	1:9	NUM
admet-2961	69	11	volume	volume	NOUN
admet-2961	69	12	ratio	ratio	NOUN
admet-2961	69	13	)	)	PUNCT
admet-2961	69	14	with	with	ADP
admet-2961	69	15	0.1	0.1	NUM
admet-2961	69	16	%	%	NOUN
admet-2961	69	17	formic	formic	ADJ
admet-2961	69	18	acid	acid	PROPN
admet-2961	69	19	and	and	CCONJ
admet-2961	69	20	analysed	analyse	VERB
admet-2961	69	21	lc	lc	NOUN
admet-2961	69	22	-	-	PUNCT
admet-2961	69	23	hrms	hrm	NOUN
admet-2961	69	24	.	.	PUNCT
admet-2961	70	1	the	the	DET
admet-2961	70	2	m7	m7	PROPN
admet-2961	70	3	metabolite	metabolite	NOUN
admet-2961	70	4	was	be	AUX
admet-2961	70	5	isolated	isolate	VERB
admet-2961	70	6	,	,	PUNCT
admet-2961	70	7	purified	purified	ADJ
admet-2961	70	8	,	,	PUNCT
admet-2961	70	9	and	and	CCONJ
admet-2961	70	10	concentrated	concentrate	VERB
admet-2961	70	11	via	via	ADP
admet-2961	70	12	a	a	DET
admet-2961	70	13	mass	mass	ADJ
admet-2961	70	14	spectrometry	spectrometry	NOUN
admet-2961	70	15	switching	switching	NOUN
admet-2961	70	16	valve	valve	NOUN
admet-2961	70	17	,	,	PUNCT
admet-2961	70	18	followed	follow	VERB
admet-2961	70	19	by	by	ADP
admet-2961	70	20	sample	sample	NOUN
admet-2961	70	21	reconstitution	reconstitution	NOUN
admet-2961	70	22	,	,	PUNCT
admet-2961	70	23	and	and	CCONJ
admet-2961	70	24	subsequent	subsequent	ADJ
admet-2961	70	25	analysis	analysis	NOUN
admet-2961	70	26	on	on	ADP
admet-2961	70	27	lc	lc	NOUN
admet-2961	70	28	-	-	PUNCT
admet-2961	70	29	hrms	hrm	NOUN
admet-2961	70	30	.	.	PUNCT
admet-2961	71	1	semi	semi	ADJ
admet-2961	71	2	-	-	ADJ
admet-2961	71	3	quantitative	quantitative	ADJ
admet-2961	71	4	and	and	CCONJ
admet-2961	71	5	qualitative	qualitative	ADJ
admet-2961	71	6	analysis	analysis	NOUN
admet-2961	71	7	semi	semi	ADJ
admet-2961	71	8	-	-	ADJ
admet-2961	71	9	quantitative	quantitative	ADJ
admet-2961	71	10	lc	lc	PROPN
admet-2961	71	11	-	-	PUNCT
admet-2961	71	12	ms	ms	PROPN
admet-2961	71	13	/	/	SYM
admet-2961	71	14	ms	ms	NOUN
admet-2961	71	15	analysis	analysis	NOUN
admet-2961	71	16	was	be	AUX
admet-2961	71	17	performed	perform	VERB
admet-2961	71	18	using	use	VERB
admet-2961	71	19	an	an	DET
admet-2961	71	20	lc30	lc30	PROPN
admet-2961	71	21	pump	pump	NOUN
admet-2961	71	22	(	(	PUNCT
admet-2961	71	23	shimadzu	shimadzu	PROPN
admet-2961	71	24	,	,	PUNCT
admet-2961	71	25	japan	japan	PROPN
admet-2961	71	26	)	)	PUNCT
admet-2961	71	27	coupled	couple	VERB
admet-2961	71	28	to	to	ADP
admet-2961	71	29	an	an	DET
admet-2961	71	30	api	api	NOUN
admet-2961	71	31	5500	5500	NUM
admet-2961	71	32	mass	mass	NOUN
admet-2961	71	33	spectrometer	spectrometer	NOUN
admet-2961	71	34	.	.	PUNCT
admet-2961	72	1	the	the	DET
admet-2961	72	2	mobile	mobile	ADJ
admet-2961	72	3	phase	phase	NOUN
admet-2961	72	4	a	a	PRON
admet-2961	72	5	was	be	AUX
admet-2961	72	6	distilled	distil	VERB
admet-2961	72	7	water	water	NOUN
admet-2961	72	8	containing	contain	VERB
admet-2961	72	9	0.1	0.1	NUM
admet-2961	72	10	%	%	NOUN
admet-2961	72	11	formic	formic	ADJ
admet-2961	72	12	acid	acid	NOUN
admet-2961	72	13	and	and	CCONJ
admet-2961	72	14	the	the	DET
admet-2961	72	15	mobile	mobile	ADJ
admet-2961	72	16	phase	phase	NOUN
admet-2961	72	17	b	b	NOUN
admet-2961	72	18	was	be	AUX
admet-2961	72	19	acetonitrile	acetonitrile	NOUN
admet-2961	72	20	containing	contain	VERB
admet-2961	72	21	0.1	0.1	NUM
admet-2961	72	22	%	%	NOUN
admet-2961	72	23	formic	formic	ADJ
admet-2961	72	24	acid	acid	NOUN
admet-2961	72	25	.	.	PUNCT
admet-2961	73	1	the	the	DET
admet-2961	73	2	lc	lc	PROPN
admet-2961	73	3	gradient	gradient	NOUN
admet-2961	73	4	was	be	AUX
admet-2961	73	5	as	as	SCONJ
admet-2961	73	6	follows	follow	VERB
admet-2961	73	7	:	:	PUNCT
admet-2961	73	8	0	0	NUM
admet-2961	73	9	to	to	PART
admet-2961	73	10	0.80	0.80	NUM
admet-2961	73	11	min	min	NOUN
admet-2961	73	12	at	at	ADP
admet-2961	73	13	5	5	NUM
admet-2961	73	14	%	%	NOUN
admet-2961	73	15	b	b	NOUN
admet-2961	73	16	;	;	PUNCT
admet-2961	73	17	0.80	0.80	NUM
admet-2961	73	18	to	to	PART
admet-2961	73	19	1.20	1.20	NUM
admet-2961	73	20	min	min	NOUN
admet-2961	73	21	,	,	PUNCT
admet-2961	73	22	5	5	NUM
admet-2961	73	23	to	to	PART
admet-2961	73	24	95	95	NUM
admet-2961	73	25	%	%	NOUN
admet-2961	73	26	b	b	NOUN
admet-2961	73	27	;	;	PUNCT
admet-2961	73	28	1.20	1.20	NUM
admet-2961	73	29	to	to	PART
admet-2961	73	30	1.80	1.80	NUM
admet-2961	73	31	min	min	NOUN
admet-2961	73	32	at	at	ADP
admet-2961	73	33	95	95	NUM
admet-2961	73	34	%	%	NOUN
admet-2961	73	35	b	b	NOUN
admet-2961	73	36	;	;	PUNCT
admet-2961	73	37	1.80	1.80	NUM
admet-2961	73	38	to	to	ADP
admet-2961	73	39	1.81	1.81	NUM
admet-2961	73	40	min	min	NOUN
admet-2961	73	41	,	,	PUNCT
admet-2961	73	42	95	95	NUM
admet-2961	73	43	to	to	PART
admet-2961	73	44	5	5	NUM
admet-2961	73	45	%	%	NOUN
admet-2961	73	46	b	b	NOUN
admet-2961	73	47	;	;	PUNCT
admet-2961	73	48	and	and	CCONJ
admet-2961	73	49	1.81	1.81	NUM
admet-2961	73	50	to	to	PART
admet-2961	73	51	2.5	2.5	NUM
admet-2961	73	52	min	min	NOUN
admet-2961	74	1	at	at	ADP
admet-2961	74	2	5	5	NUM
admet-2961	74	3	%	%	NOUN
admet-2961	74	4	b	b	NOUN
admet-2961	74	5	(	(	PUNCT
admet-2961	74	6	flow	flow	NOUN
admet-2961	74	7	rate	rate	NOUN
admet-2961	74	8	:	:	PUNCT
admet-2961	74	9	0.8	0.8	NUM
admet-2961	74	10	ml	ml	NUM
admet-2961	74	11	min-1	min-1	NOUN
admet-2961	74	12	)	)	PUNCT
admet-2961	75	1	.	.	PUNCT
admet-2961	76	1	ms	ms	PROPN
admet-2961	76	2	parameters	parameter	NOUN
admet-2961	76	3	included	include	VERB
admet-2961	76	4	:	:	PUNCT
admet-2961	76	5	curtain	curtain	NOUN
admet-2961	76	6	gas	gas	NOUN
admet-2961	76	7	:	:	PUNCT
admet-2961	76	8	2.76	2.76	NUM
admet-2961	76	9	mpa	mpa	NOUN
admet-2961	76	10	,	,	PUNCT
admet-2961	76	11	gas	gas	NOUN
admet-2961	76	12	1	1	NUM
admet-2961	76	13	:	:	PUNCT
admet-2961	76	14	2.76	2.76	NUM
admet-2961	76	15	mpa	mpa	NOUN
admet-2961	76	16	,	,	PUNCT
admet-2961	76	17	gas	gas	NOUN
admet-2961	76	18	2	2	NUM
admet-2961	76	19	:	:	SYM
admet-2961	76	20	4.14	4.14	NUM
admet-2961	76	21	mpa	mpa	NOUN
admet-2961	76	22	,	,	PUNCT
admet-2961	76	23	ion	ion	NOUN
admet-2961	76	24	source	source	NOUN
admet-2961	76	25	voltage	voltage	NOUN
admet-2961	76	26	:	:	PUNCT
admet-2961	76	27	5500	5500	NUM
admet-2961	76	28	v	v	NOUN
admet-2961	76	29	,	,	PUNCT
admet-2961	76	30	source	source	NOUN
admet-2961	76	31	temperature	temperature	NOUN
admet-2961	76	32	:	:	PUNCT
admet-2961	76	33	550	550	NUM
admet-2961	76	34	°	°	NOUN
admet-2961	76	35	c	c	NOUN
admet-2961	76	36	,	,	PUNCT
admet-2961	76	37	auxiliary	auxiliary	ADJ
admet-2961	76	38	nitrogen	nitrogen	NOUN
admet-2961	76	39	pressure	pressure	NOUN
admet-2961	76	40	:	:	PUNCT
admet-2961	76	41	0.7	0.7	NUM
admet-2961	76	42	mpa	mpa	NOUN
admet-2961	76	43	,	,	PUNCT
admet-2961	76	44	and	and	CCONJ
admet-2961	76	45	entrance	entrance	NOUN
admet-2961	76	46	potential	potential	ADJ
admet-2961	76	47	voltage	voltage	NOUN
admet-2961	76	48	:	:	PUNCT
admet-2961	76	49	10	10	NUM
admet-2961	76	50	ev	ev	NOUN
admet-2961	76	51	.	.	PROPN
admet-2961	76	52	data	datum	NOUN
admet-2961	76	53	was	be	AUX
admet-2961	76	54	acquired	acquire	VERB
admet-2961	76	55	in	in	ADP
admet-2961	76	56	multiple	multiple	ADJ
admet-2961	76	57	ions	ion	NOUN
admet-2961	76	58	monitor	monitor	NOUN
admet-2961	76	59	mode	mode	NOUN
admet-2961	76	60	using	use	VERB
admet-2961	76	61	analyst	analyst	NOUN
admet-2961	76	62	1.6.3	1.6.3	NUM
admet-2961	76	63	software	software	NOUN
admet-2961	76	64	(	(	PUNCT
admet-2961	76	65	sciex	sciex	NOUN
admet-2961	76	66	,	,	PUNCT
admet-2961	76	67	usa	usa	PROPN
admet-2961	76	68	;	;	PUNCT
admet-2961	76	69	https://sciex.com/products/software/analyst-software	https://sciex.com/products/software/analyst-software	PROPN
admet-2961	76	70	)	)	PUNCT
admet-2961	76	71	.	.	PUNCT
admet-2961	77	1	qualitative	qualitative	ADJ
admet-2961	77	2	lc	lc	NOUN
admet-2961	77	3	-	-	PUNCT
admet-2961	77	4	hrms	hrm	NOUN
admet-2961	77	5	analysis	analysis	NOUN
admet-2961	77	6	was	be	AUX
admet-2961	77	7	conducted	conduct	VERB
admet-2961	77	8	using	use	VERB
admet-2961	77	9	an	an	DET
admet-2961	77	10	ultimate	ultimate	ADJ
admet-2961	77	11	3000	3000	NUM
admet-2961	77	12	pump	pump	NOUN
admet-2961	77	13	(	(	PUNCT
admet-2961	77	14	thermofisher	thermofisher	PROPN
admet-2961	77	15	,	,	PUNCT
admet-2961	77	16	germany	germany	PROPN
admet-2961	77	17	)	)	PUNCT
admet-2961	77	18	and	and	CCONJ
admet-2961	77	19	a	a	DET
admet-2961	77	20	q	q	ADJ
admet-2961	77	21	-	-	ADJ
admet-2961	77	22	exactive	exactive	ADJ
admet-2961	77	23	plus	plus	CCONJ
admet-2961	77	24	spectrometer	spectrometer	NOUN
admet-2961	77	25	.	.	PUNCT
admet-2961	78	1	the	the	DET
admet-2961	78	2	mobile	mobile	ADJ
admet-2961	78	3	phase	phase	NOUN
admet-2961	78	4	a	a	PRON
admet-2961	78	5	was	be	AUX
admet-2961	78	6	distilled	distil	VERB
admet-2961	78	7	water	water	NOUN
admet-2961	78	8	containing	contain	VERB
admet-2961	78	9	0.1	0.1	NUM
admet-2961	78	10	%	%	NOUN
admet-2961	78	11	formic	formic	ADJ
admet-2961	78	12	acid	acid	NOUN
admet-2961	78	13	and	and	CCONJ
admet-2961	78	14	the	the	DET
admet-2961	78	15	mobile	mobile	ADJ
admet-2961	78	16	phase	phase	NOUN
admet-2961	78	17	b	b	NOUN
admet-2961	78	18	was	be	AUX
admet-2961	78	19	acetonitrile	acetonitrile	NOUN
admet-2961	78	20	containing	contain	VERB
admet-2961	78	21	0.1	0.1	NUM
admet-2961	78	22	%	%	NOUN
admet-2961	78	23	formic	formic	ADJ
admet-2961	78	24	acid	acid	NOUN
admet-2961	78	25	.	.	PUNCT
admet-2961	79	1	the	the	DET
admet-2961	79	2	liquid	liquid	ADJ
admet-2961	79	3	chromatography	chromatography	NOUN
admet-2961	79	4	(	(	PUNCT
admet-2961	79	5	lc	lc	NOUN
admet-2961	79	6	)	)	PUNCT
admet-2961	79	7	gradient	gradient	NOUN
admet-2961	79	8	spanned	span	VERB
admet-2961	79	9	22	22	NUM
admet-2961	79	10	min	min	NOUN
admet-2961	79	11	:	:	PUNCT
admet-2961	79	12	0	0	NUM
admet-2961	79	13	to	to	PART
admet-2961	79	14	1.0	1.0	NUM
admet-2961	79	15	minute	minute	NOUN
admet-2961	79	16	at	at	ADP
admet-2961	79	17	5	5	NUM
admet-2961	79	18	%	%	NOUN
admet-2961	79	19	b	b	NOUN
admet-2961	79	20	;	;	PUNCT
admet-2961	79	21	1.0	1.0	NUM
admet-2961	79	22	to	to	PART
admet-2961	79	23	6.0	6.0	NUM
admet-2961	79	24	min	min	NOUN
admet-2961	79	25	,	,	PUNCT
admet-2961	79	26	5	5	NUM
admet-2961	79	27	to	to	PART
admet-2961	79	28	15	15	NUM
admet-2961	79	29	%	%	NOUN
admet-2961	79	30	b	b	NOUN
admet-2961	79	31	;	;	PUNCT
admet-2961	79	32	6.0	6.0	NUM
admet-2961	79	33	to	to	PART
admet-2961	79	34	14.0	14.0	NUM
admet-2961	79	35	mi	mi	NOUN
admet-2961	79	36	,	,	PUNCT
admet-2961	79	37	15	15	NUM
admet-2961	79	38	to	to	PART
admet-2961	79	39	25	25	NUM
admet-2961	79	40	%	%	NOUN
admet-2961	79	41	b	b	NOUN
admet-2961	79	42	;	;	PUNCT
admet-2961	79	43	14.0	14.0	NUM
admet-2961	79	44	to	to	PART
admet-2961	79	45	16.0	16.0	NUM
admet-2961	79	46	min	min	NOUN
admet-2961	79	47	,	,	PUNCT
admet-2961	79	48	25	25	NUM
admet-2961	79	49	to	to	PART
admet-2961	79	50	90	90	NUM
admet-2961	79	51	%	%	NOUN
admet-2961	79	52	b	b	NOUN
admet-2961	79	53	;	;	PUNCT
admet-2961	79	54	16.0	16.0	NUM
admet-2961	79	55	to	to	PART
admet-2961	79	56	18.0	18.0	NUM
admet-2961	79	57	min	min	NOUN
admet-2961	79	58	,	,	PUNCT
admet-2961	79	59	90	90	NUM
admet-2961	79	60	to	to	PART
admet-2961	79	61	95	95	NUM
admet-2961	79	62	%	%	NOUN
admet-2961	79	63	b	b	NOUN
admet-2961	79	64	;	;	PUNCT
admet-2961	79	65	18.0	18.0	NUM
admet-2961	79	66	to	to	PART
admet-2961	79	67	20.0	20.0	NUM
admet-2961	79	68	min	min	NOUN
admet-2961	79	69	,	,	PUNCT
admet-2961	79	70	95	95	NUM
admet-2961	79	71	to	to	PART
admet-2961	79	72	5	5	NUM
admet-2961	79	73	%	%	NOUN
admet-2961	79	74	b	b	NOUN
admet-2961	79	75	;	;	PUNCT
admet-2961	79	76	and	and	CCONJ
admet-2961	79	77	20.0	20.0	NUM
admet-2961	79	78	to	to	PART
admet-2961	79	79	22.0	22.0	NUM
admet-2961	79	80	min	min	NOUN
admet-2961	80	1	at	at	ADP
admet-2961	80	2	5	5	NUM
admet-2961	80	3	%	%	NOUN
admet-2961	80	4	b	b	NOUN
admet-2961	80	5	(	(	PUNCT
admet-2961	80	6	flow	flow	NOUN
admet-2961	80	7	rate	rate	NOUN
admet-2961	80	8	:	:	PUNCT
admet-2961	80	9	0.3	0.3	NUM
admet-2961	80	10	ml	ml	NOUN
admet-2961	80	11	min-1	min-1	NOUN
admet-2961	80	12	)	)	PUNCT
admet-2961	81	1	.	.	PUNCT
admet-2961	82	1	ms	ms	PROPN
admet-2961	82	2	parameters	parameter	NOUN
admet-2961	82	3	included	include	VERB
admet-2961	82	4	:	:	PUNCT
admet-2961	82	5	spray	spray	NOUN
admet-2961	82	6	voltage	voltage	NOUN
admet-2961	82	7	:	:	PUNCT
admet-2961	82	8	3.8	3.8	NUM
admet-2961	82	9	kv	kv	NOUN
admet-2961	82	10	,	,	PUNCT
admet-2961	82	11	capillary	capillary	ADJ
admet-2961	82	12	temperature	temperature	NOUN
admet-2961	82	13	:	:	PUNCT
admet-2961	82	14	320	320	NUM
admet-2961	82	15	°	°	NOUN
admet-2961	82	16	c	c	NOUN
admet-2961	82	17	,	,	PUNCT
admet-2961	82	18	heater	heater	NOUN
admet-2961	82	19	temperatures	temperature	NOUN
admet-2961	82	20	:	:	PUNCT
admet-2961	82	21	350	350	NUM
admet-2961	82	22	°	°	NOUN
admet-2961	82	23	c	c	NOUN
admet-2961	82	24	,	,	PUNCT
admet-2961	82	25	sheath	sheath	NOUN
admet-2961	82	26	gas	gas	NOUN
admet-2961	82	27	:	:	PUNCT
admet-2961	82	28	2.76	2.76	NUM
admet-2961	82	29	mpa	mpa	NOUN
admet-2961	82	30	,	,	PUNCT
admet-2961	82	31	auxiliary	auxiliary	ADJ
admet-2961	82	32	nitrogen	nitrogen	NOUN
admet-2961	82	33	pressures	pressure	NOUN
admet-2961	82	34	:	:	PUNCT
admet-2961	82	35	0.7	0.7	NUM
admet-2961	82	36	mpa	mpa	NOUN
admet-2961	82	37	and	and	CCONJ
admet-2961	82	38	tube	tube	NOUN
admet-2961	82	39	lens	lens	NOUN
admet-2961	82	40	voltage	voltage	NOUN
admet-2961	82	41	:	:	PUNCT
admet-2961	82	42	10	10	NUM
admet-2961	82	43	ev	ev	NOUN
admet-2961	82	44	.	.	PUNCT
admet-2961	83	1	the	the	DET
admet-2961	83	2	full	full	ADJ
admet-2961	83	3	scan	scan	PROPN
admet-2961	83	4	q1	q1	PROPN
admet-2961	83	5	resolution	resolution	NOUN
admet-2961	83	6	was	be	AUX
admet-2961	83	7	set	set	VERB
admet-2961	83	8	to	to	ADP
admet-2961	83	9	70,000	70,000	NUM
admet-2961	83	10	,	,	PUNCT
admet-2961	83	11	and	and	CCONJ
admet-2961	83	12	the	the	DET
admet-2961	83	13	automatic	automatic	ADJ
admet-2961	83	14	gain	gain	NOUN
admet-2961	83	15	control	control	NOUN
admet-2961	83	16	(	(	PUNCT
admet-2961	83	17	agc	agc	NOUN
admet-2961	83	18	)	)	PUNCT
admet-2961	83	19	target	target	NOUN
admet-2961	83	20	value	value	NOUN
admet-2961	83	21	was	be	AUX
admet-2961	83	22	set	set	VERB
admet-2961	83	23	to	to	ADP
admet-2961	83	24	5×105	5×105	NUM
admet-2961	83	25	intensity	intensity	NOUN
admet-2961	83	26	.	.	PUNCT
admet-2961	84	1	the	the	DET
admet-2961	84	2	maximum	maximum	ADJ
admet-2961	84	3	injection	injection	NOUN
admet-2961	84	4	time	time	NOUN
admet-2961	84	5	was	be	AUX
admet-2961	84	6	limited	limit	VERB
admet-2961	84	7	to	to	ADP
admet-2961	84	8	50	50	NUM
admet-2961	84	9	ms	ms	NOUN
admet-2961	84	10	.	.	PUNCT
admet-2961	85	1	the	the	DET
admet-2961	85	2	dd	dd	ADJ
admet-2961	85	3	-	-	PUNCT
admet-2961	85	4	ms2	ms2	NOUN
admet-2961	85	5	resolution	resolution	NOUN
admet-2961	85	6	was	be	AUX
admet-2961	85	7	set	set	VERB
admet-2961	85	8	at	at	ADP
admet-2961	85	9	17,500	17,500	NUM
admet-2961	85	10	,	,	PUNCT
admet-2961	85	11	with	with	ADP
admet-2961	85	12	the	the	DET
admet-2961	85	13	agc	agc	PROPN
admet-2961	85	14	target	target	NOUN
admet-2961	85	15	set	set	VERB
admet-2961	85	16	at	at	ADP
admet-2961	85	17	5×104	5×104	PROPN
admet-2961	85	18	.	.	PUNCT
admet-2961	86	1	external	external	ADJ
admet-2961	86	2	calibration	calibration	NOUN
admet-2961	86	3	was	be	AUX
admet-2961	86	4	performed	perform	VERB
admet-2961	86	5	,	,	PUNCT
admet-2961	86	6	yielding	yield	VERB
admet-2961	86	7	a	a	DET
admet-2961	86	8	deviation	deviation	NOUN
admet-2961	86	9	of	of	ADP
admet-2961	86	10	less	less	ADJ
admet-2961	86	11	than	than	ADP
admet-2961	86	12	5.0	5.0	NUM
admet-2961	86	13	ppm	ppm	NOUN
admet-2961	86	14	.	.	PUNCT
admet-2961	87	1	data	datum	NOUN
admet-2961	87	2	was	be	AUX
admet-2961	87	3	processed	process	VERB
admet-2961	87	4	using	use	VERB
admet-2961	87	5	xcalibur	xcalibur	PROPN
admet-2961	87	6	4.1.31.9	4.1.31.9	PROPN
admet-2961	87	7	software	software	NOUN
admet-2961	87	8	(	(	PUNCT
admet-2961	87	9	thermofisher	thermofisher	PROPN
admet-2961	87	10	,	,	PUNCT
admet-2961	87	11	germany	germany	PROPN
admet-2961	87	12	;	;	PUNCT
admet-2961	87	13	https://www.thermofisher.com/order/catalog/product/opton-30965	https://www.thermofisher.com/order/catalog/product/opton-30965	NOUN
admet-2961	87	14	)	)	PUNCT
admet-2961	87	15	.	.	PUNCT
admet-2961	88	1	data	datum	NOUN
admet-2961	88	2	analysis	analysis	NOUN
admet-2961	88	3	lc	lc	PROPN
admet-2961	88	4	-	-	PUNCT
admet-2961	88	5	ms	ms	PROPN
admet-2961	88	6	/	/	SYM
admet-2961	88	7	ms	ms	PROPN
admet-2961	88	8	raw	raw	ADJ
admet-2961	88	9	data	datum	NOUN
admet-2961	88	10	was	be	AUX
admet-2961	88	11	analysed	analyse	VERB
admet-2961	88	12	using	use	VERB
admet-2961	88	13	analyst	analyst	NOUN
admet-2961	88	14	software	software	NOUN
admet-2961	88	15	,	,	PUNCT
admet-2961	88	16	and	and	CCONJ
admet-2961	88	17	hepatic	hepatic	ADJ
admet-2961	88	18	clearance	clearance	NOUN
admet-2961	88	19	results	result	NOUN
admet-2961	88	20	(	(	PUNCT
admet-2961	88	21	mean±sd	mean±sd	NUM
admet-2961	88	22	)	)	PUNCT
admet-2961	88	23	was	be	AUX
admet-2961	88	24	processsed	processse	VERB
admet-2961	88	25	with	with	ADP
admet-2961	88	26	graphpad	graphpad	NOUN
admet-2961	88	27	prism	prism	NOUN
admet-2961	88	28	5.0	5.0	NUM
admet-2961	88	29	(	(	PUNCT
admet-2961	88	30	graphpad	graphpad	NOUN
admet-2961	88	31	software	software	NOUN
admet-2961	88	32	,	,	PUNCT
admet-2961	88	33	usa	usa	PROPN
admet-2961	88	34	;	;	PUNCT
admet-2961	88	35	https://www.graphpad.com/	https://www.graphpad.com/	NOUN
admet-2961	88	36	)	)	PUNCT
admet-2961	88	37	.	.	PUNCT
admet-2961	89	1	phenotyping	phenotype	VERB
admet-2961	89	2	data	datum	NOUN
admet-2961	89	3	(	(	PUNCT
admet-2961	89	4	mean	mean	ADJ
admet-2961	89	5	values	value	NOUN
admet-2961	89	6	)	)	PUNCT
admet-2961	89	7	was	be	AUX
admet-2961	89	8	analysed	analyse	VERB
admet-2961	89	9	using	use	VERB
admet-2961	89	10	microsoft	microsoft	PROPN
admet-2961	89	11	excel	excel	VERB
admet-2961	89	12	2021	2021	NUM
admet-2961	89	13	(	(	PUNCT
admet-2961	89	14	mean	mean	ADJ
admet-2961	89	15	values	value	NOUN
admet-2961	89	16	)	)	PUNCT
admet-2961	89	17	.	.	PUNCT
admet-2961	90	1	hepatic	hepatic	ADJ
admet-2961	90	2	clearance	clearance	NOUN
admet-2961	90	3	was	be	AUX
admet-2961	90	4	determined	determine	VERB
admet-2961	90	5	by	by	ADP
admet-2961	90	6	quantifying	quantify	VERB
admet-2961	90	7	metoprolol	metoprolol	NOUN
admet-2961	90	8	depletion	depletion	NOUN
admet-2961	90	9	following	follow	VERB
admet-2961	90	10	incubation	incubation	NOUN
admet-2961	90	11	with	with	ADP
admet-2961	90	12	hepatocytes	hepatocyte	NOUN
admet-2961	90	13	.	.	PUNCT
admet-2961	91	1	the	the	DET
admet-2961	91	2	in	in	ADP
admet-2961	91	3	vivo	vivo	ADJ
admet-2961	91	4	hepatic	hepatic	ADJ
admet-2961	91	5	clearance	clearance	NOUN
admet-2961	91	6	was	be	AUX
admet-2961	91	7	subsequently	subsequently	ADV
admet-2961	91	8	extrapolated	extrapolate	VERB
admet-2961	91	9	using	use	VERB
admet-2961	91	10	the	the	DET
admet-2961	91	11	well	well	ADV
admet-2961	91	12	-	-	PUNCT
admet-2961	91	13	stirred	stir	VERB
admet-2961	91	14	model	model	NOUN
admet-2961	91	15	incorporating	incorporate	VERB
admet-2961	91	16	intrinsic	intrinsic	ADJ
admet-2961	91	17	clearance	clearance	NOUN
admet-2961	91	18	[	[	X
admet-2961	91	19	70	70	NUM
admet-2961	91	20	-	-	SYM
admet-2961	91	21	72	72	NUM
admet-2961	91	22	]	]	PUNCT
admet-2961	91	23	.	.	PUNCT
admet-2961	92	1	hepatocyte	hepatocyte	PROPN
admet-2961	92	2	viability	viability	NOUN
admet-2961	92	3	data	datum	NOUN
admet-2961	92	4	was	be	AUX
admet-2961	92	5	expressed	express	VERB
admet-2961	92	6	as	as	ADP
admet-2961	92	7	mean±sd	mean±sd	PROPN
admet-2961	92	8	.	.	PUNCT
admet-2961	93	1	the	the	DET
admet-2961	93	2	statistical	statistical	ADJ
admet-2961	93	3	significance	significance	NOUN
admet-2961	93	4	was	be	AUX
admet-2961	93	5	determined	determine	VERB
admet-2961	93	6	by	by	ADP
admet-2961	93	7	student	student	NOUN
admet-2961	93	8	's	's	PART
admet-2961	93	9	t	t	PROPN
admet-2961	93	10	-	-	PUNCT
admet-2961	93	11	test	test	NOUN
admet-2961	93	12	using	use	VERB
admet-2961	93	13	graphpad	graphpad	NOUN
admet-2961	93	14	prism	prism	NOUN
admet-2961	93	15	.	.	PUNCT
admet-2961	94	1	lc	lc	NOUN
admet-2961	94	2	-	-	PUNCT
admet-2961	94	3	hrms	hrm	VERB
admet-2961	94	4	raw	raw	ADJ
admet-2961	94	5	data	datum	NOUN
admet-2961	94	6	was	be	AUX
admet-2961	94	7	extracted	extract	VERB
admet-2961	94	8	with	with	ADP
admet-2961	94	9	xcalibur	xcalibur	PROPN
admet-2961	94	10	,	,	PUNCT
admet-2961	94	11	and	and	CCONJ
admet-2961	94	12	metabolites	metabolite	NOUN
admet-2961	94	13	were	be	AUX
admet-2961	94	14	identified	identify	VERB
admet-2961	94	15	using	use	VERB
admet-2961	94	16	compound	compound	NOUN
admet-2961	94	17	discoverer	discoverer	NOUN
admet-2961	94	18	3.0	3.0	NUM
admet-2961	94	19	(	(	PUNCT
admet-2961	94	20	thermofisher	thermofisher	PROPN
admet-2961	94	21	,	,	PUNCT
admet-2961	94	22	germany	germany	PROPN
admet-2961	94	23	;	;	PUNCT
admet-2961	94	24	https://www.thermofisher.com/order/catalog/product/opton-31061	https://www.thermofisher.com/order/catalog/product/opton-31061	PROPN
admet-2961	94	25	)	)	PUNCT
admet-2961	94	26	by	by	ADP
admet-2961	94	27	comparing	compare	VERB
admet-2961	94	28	fragment	fragment	NOUN
admet-2961	94	29	patterns	pattern	NOUN
admet-2961	94	30	between	between	ADP
admet-2961	94	31	parent	parent	NOUN
admet-2961	94	32	compounds	compound	NOUN
admet-2961	94	33	,	,	PUNCT
admet-2961	94	34	metabolites	metabolite	NOUN
admet-2961	94	35	,	,	PUNCT
admet-2961	94	36	and	and	CCONJ
admet-2961	94	37	standards	standard	NOUN
admet-2961	94	38	.	.	PUNCT
admet-2961	95	1	results	result	NOUN
admet-2961	95	2	and	and	CCONJ
admet-2961	95	3	discussion	discussion	NOUN
admet-2961	95	4	hepatocytes	hepatocyte	VERB
admet-2961	95	5	viability	viability	NOUN
admet-2961	95	6	,	,	PUNCT
admet-2961	95	7	metabolic	metabolic	NOUN
admet-2961	95	8	stability	stability	NOUN
admet-2961	95	9	and	and	CCONJ
admet-2961	95	10	phenotyping	phenotyping	NOUN
admet-2961	95	11	study	study	NOUN
admet-2961	95	12	the	the	DET
admet-2961	95	13	cytotoxic	cytotoxic	ADJ
admet-2961	95	14	effects	effect	NOUN
admet-2961	95	15	of	of	ADP
admet-2961	95	16	metoprolol	metoprolol	NOUN
admet-2961	95	17	were	be	AUX
admet-2961	95	18	assessed	assess	VERB
admet-2961	95	19	in	in	ADP
admet-2961	95	20	plateable	plateable	ADJ
admet-2961	95	21	rat	rat	NOUN
admet-2961	95	22	and	and	CCONJ
admet-2961	95	23	human	human	ADJ
admet-2961	95	24	hepatocytes	hepatocyte	NOUN
admet-2961	95	25	using	use	VERB
admet-2961	95	26	the	the	DET
admet-2961	95	27	celltiter	celltiter	NOUN
admet-2961	95	28	-	-	PUNCT
admet-2961	95	29	glo	glo	NOUN
admet-2961	95	30	®	®	NOUN
admet-2961	95	31	luminescent	luminescent	NOUN
admet-2961	95	32	cell	cell	NOUN
admet-2961	95	33	viability	viability	NOUN
admet-2961	95	34	assay	assay	VERB
admet-2961	95	35	.	.	PUNCT
admet-2961	96	1	in	in	ADP
admet-2961	96	2	rat	rat	NOUN
admet-2961	96	3	hepatocytes	hepatocyte	NOUN
admet-2961	96	4	,	,	PUNCT
admet-2961	96	5	metoprolol	metoprolol	PROPN
admet-2961	96	6	exhibited	exhibit	VERB
admet-2961	96	7	weak	weak	ADJ
admet-2961	96	8	cytotoxicity	cytotoxicity	NOUN
admet-2961	96	9	,	,	PUNCT
admet-2961	96	10	https://sciex.com/products/software/analyst-software	https://sciex.com/products/software/analyst-software	AUX
admet-2961	96	11	https://www.thermofisher.com/order/catalog/product/opton-30965	https://www.thermofisher.com/order/catalog/product/opton-30965	PROPN
admet-2961	96	12	https://www.graphpad.com/	https://www.graphpad.com/	NOUN
admet-2961	96	13	https://www.thermofisher.com/order/catalog/product/opton-31061	https://www.thermofisher.com/order/catalog/product/opton-31061	PROPN
admet-2961	96	14	admet	admet	PROPN
admet-2961	96	15	&	&	CCONJ
admet-2961	96	16	dmpk	dmpk	PROPN
admet-2961	96	17	16(5	16(5	NUM
admet-2961	96	18	)	)	PUNCT
admet-2961	96	19	(	(	PUNCT
admet-2961	96	20	2025	2025	NUM
admet-2961	96	21	)	)	PUNCT
admet-2961	96	22	2961	2961	NUM
admet-2961	96	23	natural	natural	ADJ
admet-2961	96	24	molecules	molecule	NOUN
admet-2961	96	25	for	for	ADP
admet-2961	96	26	emt	emt	PROPN
admet-2961	96	27	treatment	treatment	NOUN
admet-2961	96	28	doi	doi	NOUN
admet-2961	96	29	:	:	PUNCT
admet-2961	96	30	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	X
admet-2961	96	31	5	5	NUM
admet-2961	96	32	with	with	ADP
admet-2961	96	33	significant	significant	ADJ
admet-2961	96	34	reductions	reduction	NOUN
admet-2961	96	35	(	(	PUNCT
admet-2961	96	36	>	>	SYM
admet-2961	96	37	30	30	NUM
admet-2961	96	38	%	%	NOUN
admet-2961	96	39	)	)	PUNCT
admet-2961	96	40	in	in	ADP
admet-2961	96	41	cell	cell	NOUN
admet-2961	96	42	viability	viability	NOUN
admet-2961	96	43	observed	observe	VERB
admet-2961	96	44	at	at	ADP
admet-2961	96	45	500	500	NUM
admet-2961	96	46	µm	µm	NOUN
admet-2961	96	47	(	(	PUNCT
admet-2961	96	48	figure	figure	NOUN
admet-2961	96	49	1a	1a	NOUN
admet-2961	96	50	)	)	PUNCT
admet-2961	96	51	.	.	PUNCT
admet-2961	97	1	1	1	NUM
admet-2961	97	2	-	-	PUNCT
admet-2961	97	3	aminobenzotriazole	aminobenzotriazole	NOUN
admet-2961	97	4	was	be	AUX
admet-2961	97	5	a	a	DET
admet-2961	97	6	classic	classic	ADJ
admet-2961	97	7	inhibitor	inhibitor	NOUN
admet-2961	97	8	of	of	ADP
admet-2961	97	9	cyp450	cyp450	NOUN
admet-2961	97	10	enzymes	enzyme	NOUN
admet-2961	97	11	;	;	PUNCT
admet-2961	97	12	pre	pre	ADJ
admet-2961	97	13	-	-	NOUN
admet-2961	97	14	treatment	treatment	NOUN
admet-2961	97	15	with	with	ADP
admet-2961	97	16	abt	abt	ADV
admet-2961	97	17	significantly	significantly	ADV
admet-2961	97	18	increased	increase	VERB
admet-2961	97	19	the	the	DET
admet-2961	97	20	viability	viability	NOUN
admet-2961	97	21	of	of	ADP
admet-2961	97	22	rat	rat	NOUN
admet-2961	97	23	hepatocytes	hepatocyte	NOUN
admet-2961	97	24	and	and	CCONJ
admet-2961	97	25	reversed	reverse	VERB
admet-2961	97	26	the	the	DET
admet-2961	97	27	cytotoxic	cytotoxic	ADJ
admet-2961	97	28	effect	effect	NOUN
admet-2961	97	29	at	at	ADP
admet-2961	97	30	500	500	NUM
admet-2961	97	31	µm	µm	NOUN
admet-2961	97	32	.	.	PUNCT
admet-2961	98	1	in	in	ADP
admet-2961	98	2	contrast	contrast	NOUN
admet-2961	98	3	,	,	PUNCT
admet-2961	98	4	human	human	ADJ
admet-2961	98	5	hepatocytes	hepatocyte	NOUN
admet-2961	98	6	demonstrated	demonstrate	VERB
admet-2961	98	7	greater	great	ADJ
admet-2961	98	8	resistance	resistance	NOUN
admet-2961	98	9	to	to	ADP
admet-2961	98	10	metoprolol	metoprolol	NOUN
admet-2961	98	11	-	-	PUNCT
admet-2961	98	12	induced	induce	VERB
admet-2961	98	13	cytotoxicity	cytotoxicity	NOUN
admet-2961	98	14	(	(	PUNCT
admet-2961	98	15	figure	figure	NOUN
admet-2961	98	16	1b	1b	NUM
admet-2961	98	17	)	)	PUNCT
admet-2961	98	18	.	.	PUNCT
admet-2961	99	1	no	no	DET
admet-2961	99	2	significant	significant	ADJ
admet-2961	99	3	reduction	reduction	NOUN
admet-2961	99	4	in	in	ADP
admet-2961	99	5	cell	cell	NOUN
admet-2961	99	6	viability	viability	NOUN
admet-2961	99	7	was	be	AUX
admet-2961	99	8	observed	observe	VERB
admet-2961	99	9	across	across	ADP
admet-2961	99	10	the	the	DET
admet-2961	99	11	tested	test	VERB
admet-2961	99	12	concentration	concentration	NOUN
admet-2961	99	13	range	range	NOUN
admet-2961	99	14	(	(	PUNCT
admet-2961	99	15	0	0	NUM
admet-2961	99	16	to	to	ADP
admet-2961	99	17	500	500	NUM
admet-2961	99	18	µm	µm	NUM
admet-2961	99	19	)	)	PUNCT
admet-2961	99	20	,	,	PUNCT
admet-2961	99	21	regardless	regardless	ADV
admet-2961	99	22	of	of	ADP
admet-2961	99	23	abt	abt	PROPN
admet-2961	99	24	co	co	NOUN
admet-2961	99	25	-	-	NOUN
admet-2961	99	26	treatment	treatment	NOUN
admet-2961	99	27	.	.	PUNCT
admet-2961	100	1	figure	figure	NOUN
admet-2961	100	2	1	1	NUM
admet-2961	100	3	.	.	PUNCT
admet-2961	101	1	(	(	PUNCT
admet-2961	101	2	a	a	X
admet-2961	101	3	)	)	PUNCT
admet-2961	101	4	rat	rat	NOUN
admet-2961	101	5	and	and	CCONJ
admet-2961	101	6	(	(	PUNCT
admet-2961	101	7	b	b	NOUN
admet-2961	101	8	)	)	PUNCT
admet-2961	101	9	human	human	ADJ
admet-2961	101	10	hepatocytes	hepatocytes	PROPN
admet-2961	101	11	viability	viability	NOUN
admet-2961	101	12	after	after	ADP
admet-2961	101	13	48	48	NUM
admet-2961	101	14	hours	hour	NOUN
admet-2961	101	15	of	of	ADP
admet-2961	101	16	treatment	treatment	NOUN
admet-2961	101	17	with	with	ADP
admet-2961	101	18	metoprolol	metoprolol	NOUN
admet-2961	101	19	with	with	ADP
admet-2961	101	20	or	or	CCONJ
admet-2961	101	21	without	without	ADP
admet-2961	101	22	the	the	DET
admet-2961	101	23	presence	presence	NOUN
admet-2961	101	24	of	of	ADP
admet-2961	101	25	abt	abt	PROPN
admet-2961	101	26	.	.	PUNCT
admet-2961	102	1	*	*	PUNCT
admet-2961	102	2	p	p	X
admet-2961	102	3	<	<	X
admet-2961	102	4	0.05	0.05	NUM
admet-2961	102	5	,	,	PUNCT
admet-2961	102	6	*	*	PUNCT
admet-2961	102	7	*	*	PUNCT
admet-2961	102	8	p	p	X
admet-2961	102	9	<	<	X
admet-2961	102	10	0.01	0.01	NUM
admet-2961	102	11	these	these	DET
admet-2961	102	12	metabolic	metabolic	NOUN
admet-2961	102	13	stability	stability	NOUN
admet-2961	102	14	studies	study	NOUN
admet-2961	102	15	demonstrated	demonstrate	VERB
admet-2961	102	16	that	that	SCONJ
admet-2961	102	17	metoprolol	metoprolol	PROPN
admet-2961	102	18	exhibited	exhibit	VERB
admet-2961	102	19	typical	typical	ADJ
admet-2961	102	20	low	low	ADJ
admet-2961	102	21	-	-	PUNCT
admet-2961	102	22	clearance	clearance	NOUN
admet-2961	102	23	characteristics	characteristic	NOUN
admet-2961	102	24	in	in	ADP
admet-2961	102	25	plateable	plateable	ADJ
admet-2961	102	26	hepatocytes	hepatocyte	NOUN
admet-2961	102	27	,	,	PUNCT
admet-2961	102	28	with	with	ADP
admet-2961	102	29	an	an	DET
admet-2961	102	30	in	in	ADP
admet-2961	102	31	vitro	vitro	X
admet-2961	102	32	intrinsic	intrinsic	ADJ
admet-2961	102	33	clearance	clearance	NOUN
admet-2961	102	34	(	(	PUNCT
admet-2961	102	35	clint	clint	NOUN
admet-2961	102	36	)	)	PUNCT
admet-2961	102	37	of	of	ADP
admet-2961	102	38	0.56±0.12	0.56±0.12	NUM
admet-2961	102	39	µl	µl	ADP
admet-2961	102	40	min-1	min-1	NOUN
admet-2961	102	41	per	per	ADP
admet-2961	102	42	million	million	NUM
admet-2961	102	43	cells	cell	NOUN
admet-2961	102	44	(	(	PUNCT
admet-2961	102	45	figure	figure	NOUN
admet-2961	102	46	2a	2a	NUM
admet-2961	102	47	)	)	PUNCT
admet-2961	102	48	and	and	CCONJ
admet-2961	102	49	a	a	DET
admet-2961	102	50	corresponding	corresponding	NOUN
admet-2961	102	51	in	in	ADP
admet-2961	102	52	vivo	vivo	ADJ
admet-2961	102	53	clint	clint	NOUN
admet-2961	102	54	of	of	ADP
admet-2961	102	55	1.59±0.31	1.59±0.31	NUM
admet-2961	102	56	ml	ml	ADP
admet-2961	102	57	min-1	min-1	NOUN
admet-2961	102	58	kg-1	kg-1	NOUN
admet-2961	102	59	.	.	PUNCT
admet-2961	103	1	these	these	DET
admet-2961	103	2	values	value	NOUN
admet-2961	103	3	are	be	AUX
admet-2961	103	4	significantly	significantly	ADV
admet-2961	103	5	below	below	ADP
admet-2961	103	6	the	the	DET
admet-2961	103	7	10	10	NUM
admet-2961	103	8	ml	ml	NOUN
admet-2961	103	9	min-1	min-1	NOUN
admet-2961	103	10	kg-1	kg-1	NOUN
admet-2961	103	11	threshold	threshold	VERB
admet-2961	103	12	for	for	ADP
admet-2961	103	13	low	low	ADJ
admet-2961	103	14	-	-	PUNCT
admet-2961	103	15	clearance	clearance	NOUN
admet-2961	103	16	compounds	compound	NOUN
admet-2961	103	17	and	and	CCONJ
admet-2961	103	18	align	align	VERB
admet-2961	103	19	well	well	ADV
admet-2961	103	20	with	with	ADP
admet-2961	103	21	previously	previously	ADV
admet-2961	103	22	reported	report	VERB
admet-2961	103	23	[	[	X
admet-2961	103	24	20,54	20,54	NUM
admet-2961	103	25	]	]	X
admet-2961	103	26	with	with	ADP
admet-2961	103	27	a	a	DET
admet-2961	103	28	low	low	ADJ
admet-2961	103	29	clearance	clearance	NOUN
admet-2961	103	30	of	of	ADP
admet-2961	103	31	2.2	2.2	NUM
admet-2961	103	32	±	±	NUM
admet-2961	103	33	0.7	0.7	NUM
admet-2961	103	34	μl	μl	ADP
admet-2961	103	35	min-1	min-1	NOUN
admet-2961	103	36	per	per	ADP
admet-2961	103	37	million	million	NUM
admet-2961	103	38	cells	cell	NOUN
admet-2961	103	39	in	in	ADP
admet-2961	103	40	plateable	plateable	ADJ
admet-2961	103	41	human	human	ADJ
admet-2961	103	42	hepatocytes	hepatocyte	NOUN
admet-2961	103	43	,	,	PUNCT
admet-2961	103	44	correlating	correlate	VERB
admet-2961	103	45	with	with	ADP
admet-2961	103	46	an	an	DET
admet-2961	103	47	in	in	ADP
admet-2961	103	48	vivo	vivo	ADJ
admet-2961	103	49	clearance	clearance	NOUN
admet-2961	103	50	of	of	ADP
admet-2961	103	51	1.4	1.4	NUM
admet-2961	103	52	ml	ml	NOUN
admet-2961	103	53	min-1	min-1	NOUN
admet-2961	103	54	kg-1	kg-1	NOUN
admet-2961	104	1	[	[	X
admet-2961	104	2	20	20	NUM
admet-2961	104	3	]	]	PUNCT
admet-2961	104	4	(	(	PUNCT
admet-2961	104	5	or	or	CCONJ
admet-2961	104	6	4.28	4.28	NUM
admet-2961	104	7	μl	μl	INTJ
admet-2961	104	8	min-1	min-1	NOUN
admet-2961	104	9	per	per	ADP
admet-2961	104	10	million	million	NUM
admet-2961	104	11	cells	cell	NOUN
admet-2961	104	12	[	[	X
admet-2961	104	13	73	73	NUM
admet-2961	104	14	]	]	PUNCT
admet-2961	104	15	)	)	PUNCT
admet-2961	104	16	,	,	PUNCT
admet-2961	104	17	making	make	VERB
admet-2961	104	18	the	the	DET
admet-2961	104	19	plateable	plateable	ADJ
admet-2961	104	20	hepatocytes	hepatocyte	NOUN
admet-2961	104	21	particularly	particularly	ADV
admet-2961	104	22	valuable	valuable	ADJ
admet-2961	104	23	for	for	ADP
admet-2961	104	24	evaluating	evaluate	VERB
admet-2961	104	25	low	low	ADJ
admet-2961	104	26	-	-	PUNCT
admet-2961	104	27	clearance	clearance	NOUN
admet-2961	104	28	compounds	compound	NOUN
admet-2961	104	29	[	[	X
admet-2961	104	30	74	74	NUM
admet-2961	104	31	]	]	PUNCT
admet-2961	104	32	.	.	PUNCT
admet-2961	105	1	figure	figure	NOUN
admet-2961	105	2	2	2	NUM
admet-2961	105	3	.	.	PUNCT
admet-2961	105	4	metoprolol	metoprolol	PROPN
admet-2961	105	5	remaining	remain	VERB
admet-2961	105	6	vs.	vs.	ADP
admet-2961	105	7	incubation	incubation	NOUN
admet-2961	105	8	time	time	NOUN
admet-2961	105	9	in	in	ADP
admet-2961	105	10	(	(	PUNCT
admet-2961	105	11	a	a	X
admet-2961	105	12	)	)	PUNCT
admet-2961	105	13	plateable	plateable	ADJ
admet-2961	105	14	hepatocytes	hepatocyte	NOUN
admet-2961	105	15	and	and	CCONJ
admet-2961	105	16	(	(	PUNCT
admet-2961	105	17	b)recombinant	b)recombinant	NOUN
admet-2961	105	18	enzymes	enzyme	NOUN
admet-2961	105	19	enzyme	enzyme	NOUN
admet-2961	105	20	phenotyping	phenotype	VERB
admet-2961	105	21	studies	study	NOUN
admet-2961	105	22	demonstrated	demonstrate	VERB
admet-2961	105	23	remarkable	remarkable	ADJ
admet-2961	105	24	specificity	specificity	NOUN
admet-2961	105	25	in	in	ADP
admet-2961	105	26	metoprolol	metoprolol	NOUN
admet-2961	105	27	metabolism	metabolism	NOUN
admet-2961	105	28	.	.	PUNCT
admet-2961	106	1	as	as	SCONJ
admet-2961	106	2	illustrated	illustrate	VERB
admet-2961	106	3	in	in	ADP
admet-2961	106	4	figure	figure	NOUN
admet-2961	106	5	2b	2b	NOUN
admet-2961	106	6	,	,	PUNCT
admet-2961	106	7	among	among	ADP
admet-2961	106	8	the	the	DET
admet-2961	106	9	cytochrome	cytochrome	NOUN
admet-2961	106	10	p450	p450	PROPN
admet-2961	106	11	isoforms	isoform	NOUN
admet-2961	106	12	tested	test	VERB
admet-2961	106	13	(	(	PUNCT
admet-2961	106	14	cyp1a2	cyp1a2	PROPN
admet-2961	106	15	,	,	PUNCT
admet-2961	106	16	2c9	2c9	NUM
admet-2961	106	17	,	,	PUNCT
admet-2961	106	18	2c19	2c19	NUM
admet-2961	106	19	,	,	PUNCT
admet-2961	106	20	3a4	3a4	NUM
admet-2961	106	21	,	,	PUNCT
admet-2961	106	22	2b6	2b6	NUM
admet-2961	106	23	and	and	CCONJ
admet-2961	106	24	2c8	2c8	NUM
admet-2961	106	25	)	)	PUNCT
admet-2961	106	26	,	,	PUNCT
admet-2961	106	27	only	only	ADV
admet-2961	106	28	cyp2d6	cyp2d6	NOUN
admet-2961	106	29	displayed	display	VERB
admet-2961	106	30	significant	significant	ADJ
admet-2961	106	31	metabolic	metabolic	NOUN
admet-2961	106	32	activity	activity	NOUN
admet-2961	106	33	,	,	PUNCT
admet-2961	106	34	contributing	contribute	VERB
admet-2961	106	35	to	to	ADP
admet-2961	106	36	100	100	NUM
admet-2961	106	37	%	%	NOUN
admet-2961	106	38	of	of	ADP
admet-2961	106	39	the	the	DET
admet-2961	106	40	observed	observe	VERB
admet-2961	106	41	clearance	clearance	NOUN
admet-2961	106	42	with	with	ADP
admet-2961	106	43	an	an	DET
admet-2961	106	44	intrinsic	intrinsic	ADJ
admet-2961	106	45	clearance	clearance	NOUN
admet-2961	106	46	rate	rate	NOUN
admet-2961	106	47	of	of	ADP
admet-2961	106	48	5.46	5.46	NUM
admet-2961	106	49	µl	µl	ADP
admet-2961	106	50	min-1	min-1	NOUN
admet-2961	106	51	per	per	ADP
admet-2961	106	52	pmol	pmol	NOUN
admet-2961	106	53	protein	protein	NOUN
admet-2961	106	54	.	.	PUNCT
admet-2961	107	1	this	this	DET
admet-2961	107	2	finding	finding	NOUN
admet-2961	107	3	corroborates	corroborate	VERB
admet-2961	107	4	prior	prior	ADJ
admet-2961	107	5	reports	report	NOUN
admet-2961	107	6	on	on	ADP
admet-2961	107	7	the	the	DET
admet-2961	107	8	exclusive	exclusive	ADJ
admet-2961	107	9	involvement	involvement	NOUN
admet-2961	107	10	of	of	ADP
admet-2961	107	11	cyp2d6	cyp2d6	NOUN
admet-2961	107	12	in	in	ADP
admet-2961	107	13	metoprolol	metoprolol	NOUN
admet-2961	107	14	metabolism	metabolism	NOUN
admet-2961	108	1	[	[	X
admet-2961	108	2	58	58	NUM
admet-2961	108	3	]	]	PUNCT
admet-2961	108	4	,	,	PUNCT
admet-2961	108	5	highlighting	highlight	VERB
admet-2961	108	6	its	its	PRON
admet-2961	108	7	critical	critical	ADJ
admet-2961	108	8	clinical	clinical	ADJ
admet-2961	108	9	implications	implication	NOUN
admet-2961	108	10	.	.	PUNCT
admet-2961	109	1	given	give	VERB
admet-2961	109	2	this	this	DET
admet-2961	109	3	highly	highly	ADV
admet-2961	109	4	selective	selective	ADJ
admet-2961	109	5	cyp2d6	cyp2d6	NOUN
admet-2961	109	6	-	-	PUNCT
admet-2961	109	7	dependent	dependent	ADJ
admet-2961	109	8	metabolic	metabolic	NOUN
admet-2961	109	9	pathway	pathway	NOUN
admet-2961	109	10	,	,	PUNCT
admet-2961	109	11	these	these	DET
admet-2961	109	12	results	result	NOUN
admet-2961	109	13	emphasize	emphasize	VERB
admet-2961	109	14	the	the	DET
admet-2961	109	15	importance	importance	NOUN
admet-2961	109	16	of	of	ADP
admet-2961	109	17	genotypeguided	genotypeguide	VERB
admet-2961	109	18	dosing	dosing	NOUN
admet-2961	109	19	strategies	strategy	NOUN
admet-2961	109	20	,	,	PUNCT
admet-2961	109	21	particularly	particularly	ADV
admet-2961	109	22	in	in	ADP
admet-2961	109	23	populations	population	NOUN
admet-2961	109	24	with	with	ADP
admet-2961	109	25	a	a	DET
admet-2961	109	26	high	high	ADJ
admet-2961	109	27	prevalence	prevalence	NOUN
admet-2961	109	28	of	of	ADP
admet-2961	109	29	cyp2d6	cyp2d6	NOUN
admet-2961	109	30	poor	poor	ADJ
admet-2961	109	31	metabolizers	metabolizer	NOUN
admet-2961	109	32	.	.	PUNCT
admet-2961	110	1	chromatographic	chromatographic	ADJ
admet-2961	110	2	and	and	CCONJ
admet-2961	110	3	mass	mass	ADJ
admet-2961	110	4	spectrometric	spectrometric	ADJ
admet-2961	110	5	characteristics	characteristic	NOUN
admet-2961	110	6	of	of	ADP
admet-2961	110	7	metoprolol	metoprolol	NOUN
admet-2961	110	8	and	and	CCONJ
admet-2961	110	9	its	its	PRON
admet-2961	110	10	metabolites	metabolite	NOUN
admet-2961	110	11	in	in	ADP
admet-2961	110	12	figure	figure	NOUN
admet-2961	110	13	3	3	NUM
admet-2961	110	14	,	,	PUNCT
admet-2961	110	15	metoprolol	metoprolol	PROPN
admet-2961	110	16	was	be	AUX
admet-2961	110	17	determined	determine	VERB
admet-2961	110	18	with	with	ADP
admet-2961	110	19	a	a	DET
admet-2961	110	20	protonated	protonate	VERB
admet-2961	110	21	molecular	molecular	ADJ
admet-2961	110	22	ion	ion	NOUN
admet-2961	110	23	peak	peak	NOUN
admet-2961	110	24	at	at	ADP
admet-2961	110	25	m	m	PROPN
admet-2961	110	26	/	/	SYM
admet-2961	110	27	z	z	PROPN
admet-2961	110	28	268.1914	268.1914	NUM
admet-2961	110	29	.	.	PUNCT
admet-2961	111	1	the	the	DET
admet-2961	111	2	collision	collision	NOUN
admet-2961	111	3	-	-	PUNCT
admet-2961	111	4	induced	induce	VERB
admet-2961	111	5	dissociation	dissociation	NOUN
admet-2961	111	6	(	(	PUNCT
admet-2961	111	7	cid	cid	NOUN
admet-2961	111	8	)	)	PUNCT
admet-2961	111	9	product	product	NOUN
admet-2961	111	10	ion	ion	NOUN
admet-2961	111	11	spectrum	spectrum	NOUN
admet-2961	111	12	exhibited	exhibit	VERB
admet-2961	111	13	characteristic	characteristic	ADJ
admet-2961	111	14	fragment	fragment	NOUN
admet-2961	111	15	ions	ion	NOUN
admet-2961	111	16	at	at	ADP
admet-2961	111	17	m	m	PROPN
admet-2961	111	18	/	/	SYM
admet-2961	111	19	z	z	PROPN
admet-2961	111	20	56.0499	56.0499	NUM
admet-2961	111	21	,	,	PUNCT
admet-2961	112	1	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	112	2	j.	j.	PROPN
admet-2961	112	3	pu	pu	PROPN
admet-2961	112	4	et	et	PROPN
admet-2961	112	5	al	al	PROPN
admet-2961	112	6	.	.	PROPN
admet-2961	112	7	admet	admet	PROPN
admet-2961	112	8	&	&	CCONJ
admet-2961	112	9	dmpk	dmpk	PROPN
admet-2961	112	10	13(5	13(5	NUM
admet-2961	112	11	)	)	PUNCT
admet-2961	112	12	(	(	PUNCT
admet-2961	112	13	2025	2025	NUM
admet-2961	112	14	)	)	PUNCT
admet-2961	112	15	2961	2961	NUM
admet-2961	112	16	6	6	NUM
admet-2961	112	17	72.0810	72.0810	NUM
admet-2961	112	18	,	,	PUNCT
admet-2961	112	19	98.0967	98.0967	NUM
admet-2961	112	20	,	,	PUNCT
admet-2961	112	21	116.1073	116.1073	NUM
admet-2961	112	22	,	,	PUNCT
admet-2961	112	23	121.0652	121.0652	NUM
admet-2961	112	24	,	,	PUNCT
admet-2961	112	25	133.0652	133.0652	NUM
admet-2961	112	26	,	,	PUNCT
admet-2961	112	27	159.0811	159.0811	NUM
admet-2961	112	28	and	and	CCONJ
admet-2961	112	29	191.1075	191.1075	NUM
admet-2961	112	30	,	,	PUNCT
admet-2961	112	31	supporting	support	VERB
admet-2961	112	32	its	its	PRON
admet-2961	112	33	structural	structural	ADJ
admet-2961	112	34	identification	identification	NOUN
admet-2961	112	35	.	.	PUNCT
admet-2961	113	1	the	the	DET
admet-2961	113	2	lc	lc	PROPN
admet-2961	113	3	analysis	analysis	NOUN
admet-2961	113	4	showed	show	VERB
admet-2961	113	5	a	a	DET
admet-2961	113	6	retention	retention	NOUN
admet-2961	113	7	time	time	NOUN
admet-2961	113	8	of	of	ADP
admet-2961	113	9	approximately	approximately	ADV
admet-2961	113	10	10.86	10.86	NUM
admet-2961	113	11	min	min	NOUN
admet-2961	113	12	for	for	ADP
admet-2961	113	13	the	the	DET
admet-2961	113	14	parent	parent	NOUN
admet-2961	113	15	compound	compound	NOUN
admet-2961	113	16	.	.	PUNCT
admet-2961	114	1	figure	figure	NOUN
admet-2961	114	2	3	3	NUM
admet-2961	114	3	.	.	X
admet-2961	114	4	collision	collision	NOUN
admet-2961	114	5	-	-	PUNCT
admet-2961	114	6	induced	induce	VERB
admet-2961	114	7	dissociation	dissociation	NOUN
admet-2961	114	8	spectrum	spectrum	NOUN
admet-2961	114	9	(	(	PUNCT
admet-2961	114	10	a	a	NOUN
admet-2961	114	11	)	)	PUNCT
admet-2961	114	12	and	and	CCONJ
admet-2961	114	13	structural	structural	ADJ
admet-2961	114	14	analysis	analysis	NOUN
admet-2961	114	15	(	(	PUNCT
admet-2961	114	16	b	b	NOUN
admet-2961	114	17	)	)	PUNCT
admet-2961	114	18	of	of	ADP
admet-2961	114	19	metoprolol	metoprolol	NOUN
admet-2961	114	20	as	as	SCONJ
admet-2961	114	21	summarized	summarize	VERB
admet-2961	114	22	in	in	ADP
admet-2961	114	23	table	table	NOUN
admet-2961	114	24	1	1	NUM
admet-2961	114	25	and	and	CCONJ
admet-2961	114	26	illustrated	illustrate	VERB
admet-2961	114	27	in	in	ADP
admet-2961	114	28	figure	figure	NOUN
admet-2961	114	29	4	4	NUM
admet-2961	114	30	,	,	PUNCT
admet-2961	114	31	twenty	twenty	NUM
admet-2961	114	32	-	-	PUNCT
admet-2961	114	33	two	two	NUM
admet-2961	114	34	metabolites	metabolite	NOUN
admet-2961	114	35	were	be	AUX
admet-2961	114	36	detected	detect	VERB
admet-2961	114	37	and	and	CCONJ
admet-2961	114	38	fifteen	fifteen	NUM
admet-2961	114	39	were	be	AUX
admet-2961	114	40	identified	identify	VERB
admet-2961	114	41	as	as	ADP
admet-2961	114	42	new	new	ADJ
admet-2961	114	43	in	in	ADP
admet-2961	114	44	plateable	plateable	ADJ
admet-2961	114	45	hepatocytes	hepatocyte	NOUN
admet-2961	114	46	,	,	PUNCT
admet-2961	114	47	eluting	eluting	NOUN
admet-2961	114	48	between	between	ADP
admet-2961	114	49	2.64	2.64	NUM
admet-2961	114	50	and	and	CCONJ
admet-2961	114	51	13.52	13.52	NUM
admet-2961	114	52	min	min	NOUN
admet-2961	114	53	,	,	PUNCT
admet-2961	114	54	with	with	ADP
admet-2961	114	55	effective	effective	ADJ
admet-2961	114	56	chromatographic	chromatographic	ADJ
admet-2961	114	57	separation	separation	NOUN
admet-2961	114	58	.	.	PUNCT
admet-2961	115	1	species	specie	NOUN
admet-2961	115	2	-	-	PUNCT
admet-2961	115	3	dependent	dependent	ADJ
admet-2961	115	4	metabolic	metabolic	NOUN
admet-2961	115	5	profiles	profile	NOUN
admet-2961	115	6	were	be	AUX
admet-2961	115	7	observed	observe	VERB
admet-2961	115	8	in	in	ADP
admet-2961	115	9	the	the	DET
admet-2961	115	10	metabolite	metabolite	NOUN
admet-2961	115	11	identification	identification	NOUN
admet-2961	115	12	results	result	NOUN
admet-2961	115	13	in	in	ADP
admet-2961	115	14	plateable	plateable	ADJ
admet-2961	115	15	hepatocytes	hepatocyte	NOUN
admet-2961	115	16	.	.	PUNCT
admet-2961	116	1	table	table	NOUN
admet-2961	116	2	1	1	NUM
admet-2961	116	3	.	.	PUNCT
admet-2961	116	4	observed	observe	VERB
admet-2961	116	5	metabolites	metabolite	NOUN
admet-2961	116	6	of	of	ADP
admet-2961	116	7	metoprolol	metoprolol	NOUN
admet-2961	116	8	in	in	ADP
admet-2961	116	9	recombinant	recombinant	ADJ
admet-2961	116	10	2d6	2d6	NUM
admet-2961	116	11	enzymes	enzyme	NOUN
admet-2961	116	12	and	and	CCONJ
admet-2961	116	13	plateable	plateable	ADJ
admet-2961	116	14	hepatocytes	hepatocyte	NOUN
admet-2961	116	15	i	i	PROPN
admet-2961	116	16	d	d	PROPN
admet-2961	116	17	rt	rt	PROPN
admet-2961	116	18	,	,	PUNCT
admet-2961	116	19	min	min	PROPN
admet-2961	116	20	m	m	PROPN
admet-2961	116	21	/	/	SYM
admet-2961	116	22	z	z	X
admet-2961	116	23	(	(	PUNCT
admet-2961	116	24	+	+	NOUN
admet-2961	116	25	)	)	PUNCT
admet-2961	116	26	me	i	PRON
admet-2961	116	27	,	,	PUNCT
admet-2961	116	28	ppm	ppm	ADJ
admet-2961	116	29	metabolic	metabolic	NOUN
admet-2961	116	30	pathway	pathway	NOUN
admet-2961	116	31	relative	relative	PROPN
admet-2961	116	32	peak	peak	PROPN
admet-2961	116	33	area	area	NOUN
admet-2961	116	34	,	,	PUNCT
admet-2961	116	35	%	%	INTJ
admet-2961	116	36	ref	ref	NOUN
admet-2961	116	37	.	.	PUNCT
admet-2961	117	1	theoretical	theoretical	ADJ
admet-2961	117	2	detected	detect	VERB
admet-2961	117	3	plateable	plateable	ADJ
admet-2961	117	4	hepatocytes	hepatocyte	NOUN
admet-2961	117	5	2d6a	2d6a	NOUN
admet-2961	117	6	r	r	NOUN
admet-2961	117	7	d	d	X
admet-2961	117	8	mk	mk	PROPN
admet-2961	117	9	h	h	NOUN
admet-2961	117	10	h	h	PROPN
admet-2961	117	11	m1	m1	PROPN
admet-2961	118	1	2.65	2.65	NUM
admet-2961	118	2	270.1700	270.1700	NUM
admet-2961	118	3	270.1711	270.1711	NUM
admet-2961	118	4	4.1	4.1	NUM
admet-2961	118	5	o	o	NOUN
admet-2961	118	6	-	-	NOUN
admet-2961	118	7	demethylation	demethylation	NOUN
admet-2961	118	8	and	and	CCONJ
admet-2961	118	9	monooxygenation	monooxygenation	NOUN
admet-2961	118	10	8.8	8.8	NUM
admet-2961	118	11	0.8	0.8	NUM
admet-2961	118	12	4.7	4.7	NUM
admet-2961	118	13	d	d	SYM
admet-2961	118	14	26.6	26.6	NUM
admet-2961	118	15	m2	m2	PROPN
admet-2961	118	16	2.72	2.72	NUM
admet-2961	118	17	284.1492	284.1492	NUM
admet-2961	118	18	284.1503	284.1503	NUM
admet-2961	118	19	3.9	3.9	NUM
admet-2961	118	20	oxidation	oxidation	NOUN
admet-2961	118	21	and	and	CCONJ
admet-2961	118	22	monooxygenation	monooxygenation	NOUN
admet-2961	118	23	0.9	0.9	NUM
admet-2961	119	1	d	d	NOUN
admet-2961	119	2	0.1	0.1	NUM
admet-2961	119	3	nd	nd	NOUN
admet-2961	119	4	nd	nd	NOUN
admet-2961	119	5	m3	m3	PROPN
admet-2961	119	6	3.65	3.65	NUM
admet-2961	119	7	212.1281	212.1281	NUM
admet-2961	119	8	212.1288	212.1288	NUM
admet-2961	119	9	3.3	3.3	NUM
admet-2961	119	10	o	o	NOUN
admet-2961	119	11	-	-	NOUN
admet-2961	119	12	demethylation	demethylation	NOUN
admet-2961	119	13	and	and	CCONJ
admet-2961	119	14	ndealkylation	ndealkylation	NOUN
admet-2961	119	15	d	d	ADP
admet-2961	119	16	0.7	0.7	NUM
admet-2961	119	17	0.1	0.1	NUM
admet-2961	119	18	nd	nd	NUM
admet-2961	119	19	1.6	1.6	NUM
admet-2961	119	20	m4	m4	PROPN
admet-2961	119	21	4.44	4.44	NUM
admet-2961	119	22	226.1074	226.1074	NUM
admet-2961	119	23	226.1082	226.1082	NUM
admet-2961	119	24	3.5	3.5	NUM
admet-2961	119	25	n	n	CCONJ
admet-2961	119	26	-	-	PUNCT
admet-2961	119	27	dealkylation	dealkylation	NOUN
admet-2961	119	28	and	and	CCONJ
admet-2961	119	29	oxidation	oxidation	NOUN
admet-2961	120	1	d	d	NOUN
admet-2961	120	2	nd	nd	NOUN
admet-2961	120	3	d	d	NOUN
admet-2961	120	4	nd	nd	INTJ
admet-2961	120	5	nd	nd	NOUN
admet-2961	120	6	m5	m5	PROPN
admet-2961	120	7	5.08	5.08	NUM
admet-2961	120	8	268.1543	268.1543	NUM
admet-2961	120	9	268.1552	268.1552	NUM
admet-2961	120	10	3.4	3.4	NUM
admet-2961	120	11	o	o	NOUN
admet-2961	120	12	-	-	NOUN
admet-2961	120	13	demethylation	demethylation	NOUN
admet-2961	120	14	,	,	PUNCT
admet-2961	120	15	mono	mono	NOUN
admet-2961	120	16	-	-	PUNCT
admet-2961	120	17	oxygenation	oxygenation	NOUN
admet-2961	120	18	,	,	PUNCT
admet-2961	120	19	and	and	CCONJ
admet-2961	120	20	dehydrogenation	dehydrogenation	NOUN
admet-2961	120	21	0.6	0.6	NUM
admet-2961	120	22	d	d	NOUN
admet-2961	120	23	0.1	0.1	NUM
admet-2961	120	24	nd	nd	NUM
admet-2961	120	25	2.0	2.0	NUM
admet-2961	120	26	m6	m6	ADJ
admet-2961	120	27	5.82	5.82	NUM
admet-2961	120	28	444.1864	444.1864	NUM
admet-2961	120	29	444.1878	444.1878	NUM
admet-2961	120	30	3.2	3.2	NUM
admet-2961	120	31	o	o	NOUN
admet-2961	120	32	-	-	NOUN
admet-2961	120	33	demethylation	demethylation	NOUN
admet-2961	120	34	,	,	PUNCT
admet-2961	120	35	monooxygenation	monooxygenation	NOUN
admet-2961	120	36	,	,	PUNCT
admet-2961	120	37	dehydrogenation	dehydrogenation	NOUN
admet-2961	120	38	and	and	CCONJ
admet-2961	120	39	glucuronidation	glucuronidation	NOUN
admet-2961	120	40	0.1	0.1	NUM
admet-2961	120	41	nd	nd	NUM
admet-2961	120	42	0.1	0.1	NUM
admet-2961	120	43	nd	nd	NOUN
admet-2961	120	44	nd	nd	NOUN
admet-2961	120	45	m7	m7	PROPN
admet-2961	120	46	5.86	5.86	NUM
admet-2961	120	47	589.2538	589.2538	NUM
admet-2961	120	48	589.2511	589.2511	NUM
admet-2961	120	49	-4.6	-4.6	NOUN
admet-2961	120	50	mono	mono	NOUN
admet-2961	120	51	-	-	PUNCT
admet-2961	120	52	oxygenation	oxygenation	NOUN
admet-2961	120	53	and	and	CCONJ
admet-2961	120	54	glutathionylation	glutathionylation	NOUN
admet-2961	120	55	(	(	PUNCT
admet-2961	120	56	displacement	displacement	NOUN
admet-2961	120	57	)	)	PUNCT
admet-2961	121	1	d	d	NOUN
admet-2961	121	2	nd	nd	INTJ
admet-2961	121	3	nd	nd	INTJ
admet-2961	121	4	nd	nd	NOUN
admet-2961	121	5	nd	nd	ADV
admet-2961	121	6	[	[	X
admet-2961	121	7	63	63	NUM
admet-2961	121	8	]	]	PUNCT
admet-2961	121	9	m8	m8	NOUN
admet-2961	121	10	5.96	5.96	NUM
admet-2961	121	11	270.1700	270.1700	NUM
admet-2961	121	12	270.1713	270.1713	NUM
admet-2961	121	13	4.8	4.8	NUM
admet-2961	121	14	o	o	NOUN
admet-2961	121	15	-	-	NOUN
admet-2961	121	16	demethylation	demethylation	NOUN
admet-2961	121	17	and	and	CCONJ
admet-2961	121	18	monooxygenation	monooxygenation	NOUN
admet-2961	121	19	0.1	0.1	NUM
admet-2961	121	20	nd	nd	INTJ
admet-2961	121	21	nd	nd	PRON
admet-2961	121	22	nd	nd	NOUN
admet-2961	121	23	nd	nd	NOUN
admet-2961	121	24	m9	m9	PROPN
admet-2961	121	25	6.12	6.12	NUM
admet-2961	121	26	254.1387	254.1387	NUM
admet-2961	121	27	254.1395	254.1395	NUM
admet-2961	121	28	3.1	3.1	NUM
admet-2961	121	29	oxidation	oxidation	NOUN
admet-2961	121	30	0.4	0.4	NUM
admet-2961	121	31	d	d	NOUN
admet-2961	121	32	0.2	0.2	NUM
admet-2961	121	33	d	d	NUM
admet-2961	121	34	1.7	1.7	NUM
admet-2961	121	35	[	[	X
admet-2961	121	36	69	69	NUM
admet-2961	121	37	]	]	SYM
admet-2961	121	38	m10	m10	PROPN
admet-2961	121	39	6.42	6.42	NUM
admet-2961	121	40	284.1856	284.1856	NUM
admet-2961	121	41	284.1863	284.1863	NUM
admet-2961	121	42	2.5	2.5	NUM
admet-2961	121	43	mono	mono	NOUN
admet-2961	121	44	-	-	PUNCT
admet-2961	121	45	oxygenation	oxygenation	NOUN
admet-2961	121	46	24.4	24.4	NUM
admet-2961	121	47	9.4	9.4	NUM
admet-2961	121	48	5.6	5.6	NUM
admet-2961	121	49	2.7	2.7	NUM
admet-2961	121	50	20.1	20.1	NUM
admet-2961	121	51	[	[	X
admet-2961	121	52	62,63	62,63	ADJ
admet-2961	121	53	,	,	PUNCT
admet-2961	121	54	66	66	NUM
admet-2961	121	55	-	-	SYM
admet-2961	121	56	69,73	69,73	NUM
admet-2961	121	57	]	]	PUNCT
admet-2961	121	58	m11	m11	NOUN
admet-2961	121	59	6.57	6.57	NUM
admet-2961	121	60	430.2072	430.2072	NUM
admet-2961	121	61	430.2085	430.2085	NUM
admet-2961	121	62	3.0	3.0	NUM
admet-2961	121	63	o	o	NOUN
admet-2961	121	64	-	-	NOUN
admet-2961	121	65	demethylation	demethylation	NOUN
admet-2961	121	66	and	and	CCONJ
admet-2961	121	67	glucuronidation	glucuronidation	NOUN
admet-2961	121	68	0.1	0.1	NUM
admet-2961	121	69	d	d	NOUN
admet-2961	121	70	0.2	0.2	NUM
admet-2961	121	71	nd	nd	NOUN
admet-2961	121	72	nd	nd	NOUN
admet-2961	121	73	m12	m12	NOUN
admet-2961	121	74	6.70	6.70	NUM
admet-2961	121	75	430.2072	430.2072	NUM
admet-2961	121	76	430.2082	430.2082	NUM
admet-2961	121	77	2.3	2.3	NUM
admet-2961	121	78	o	o	NOUN
admet-2961	121	79	-	-	NOUN
admet-2961	121	80	demethylation	demethylation	NOUN
admet-2961	121	81	and	and	CCONJ
admet-2961	121	82	glucuronidation	glucuronidation	NOUN
admet-2961	122	1	d	d	X
admet-2961	122	2	d	d	NOUN
admet-2961	122	3	0.2	0.2	NUM
admet-2961	122	4	d	d	NOUN
admet-2961	122	5	nd	nd	NOUN
admet-2961	122	6	m13	m13	VERB
admet-2961	122	7	6.79	6.79	NUM
admet-2961	122	8	254.1751	254.1751	NUM
admet-2961	122	9	254.1755	254.1755	NUM
admet-2961	122	10	1.6	1.6	NUM
admet-2961	122	11	o	o	NOUN
admet-2961	122	12	-	-	NOUN
admet-2961	122	13	demethylation	demethylation	NOUN
admet-2961	122	14	3.8	3.8	NUM
admet-2961	122	15	20.5	20.5	NUM
admet-2961	122	16	0.1	0.1	NUM
admet-2961	122	17	6.0	6.0	NUM
admet-2961	122	18	22.8	22.8	NUM
admet-2961	122	19	[	[	X
admet-2961	122	20	62,63	62,63	ADJ
admet-2961	122	21	,	,	PUNCT
admet-2961	122	22	66,69,73	66,69,73	PROPN
admet-2961	122	23	]	]	X
admet-2961	122	24	admet	admet	PROPN
admet-2961	122	25	&	&	CCONJ
admet-2961	122	26	dmpk	dmpk	PROPN
admet-2961	122	27	16(5	16(5	NUM
admet-2961	122	28	)	)	PUNCT
admet-2961	122	29	(	(	PUNCT
admet-2961	122	30	2025	2025	NUM
admet-2961	122	31	)	)	PUNCT
admet-2961	122	32	2961	2961	NUM
admet-2961	122	33	natural	natural	ADJ
admet-2961	122	34	molecules	molecule	NOUN
admet-2961	122	35	for	for	ADP
admet-2961	122	36	emt	emt	PROPN
admet-2961	122	37	treatment	treatment	NOUN
admet-2961	122	38	doi	doi	NOUN
admet-2961	122	39	:	:	PUNCT
admet-2961	122	40	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	122	41	7	7	NUM
admet-2961	122	42	i	i	PROPN
admet-2961	122	43	d	d	PROPN
admet-2961	122	44	rt	rt	PROPN
admet-2961	122	45	,	,	PUNCT
admet-2961	122	46	min	min	PROPN
admet-2961	122	47	m	m	PROPN
admet-2961	122	48	/	/	SYM
admet-2961	122	49	z	z	X
admet-2961	122	50	(	(	PUNCT
admet-2961	122	51	+	+	NOUN
admet-2961	122	52	)	)	PUNCT
admet-2961	122	53	me	i	PRON
admet-2961	122	54	,	,	PUNCT
admet-2961	122	55	ppm	ppm	ADJ
admet-2961	122	56	metabolic	metabolic	NOUN
admet-2961	122	57	pathway	pathway	NOUN
admet-2961	122	58	relative	relative	PROPN
admet-2961	122	59	peak	peak	PROPN
admet-2961	122	60	area	area	NOUN
admet-2961	122	61	,	,	PUNCT
admet-2961	122	62	%	%	INTJ
admet-2961	122	63	ref	ref	NOUN
admet-2961	122	64	.	.	PUNCT
admet-2961	123	1	theoretical	theoretical	ADJ
admet-2961	123	2	detected	detect	VERB
admet-2961	123	3	plateable	plateable	ADJ
admet-2961	123	4	hepatocytes	hepatocyte	NOUN
admet-2961	123	5	2d6a	2d6a	NOUN
admet-2961	123	6	r	r	NOUN
admet-2961	123	7	d	d	X
admet-2961	123	8	mk	mk	PROPN
admet-2961	123	9	h	h	NOUN
admet-2961	123	10	h	h	PROPN
admet-2961	123	11	m14	m14	VERB
admet-2961	123	12	6.97	6.97	NUM
admet-2961	123	13	589.2538	589.2538	NUM
admet-2961	123	14	589.2511	589.2511	NUM
admet-2961	123	15	-4.6	-4.6	NOUN
admet-2961	123	16	mono	mono	NOUN
admet-2961	123	17	-	-	PUNCT
admet-2961	123	18	oxygenation	oxygenation	NOUN
admet-2961	123	19	and	and	CCONJ
admet-2961	123	20	glutathionylation	glutathionylation	NOUN
admet-2961	123	21	(	(	PUNCT
admet-2961	123	22	displacement	displacement	NOUN
admet-2961	123	23	)	)	PUNCT
admet-2961	124	1	d	d	NOUN
admet-2961	124	2	nd	nd	INTJ
admet-2961	124	3	nd	nd	NOUN
admet-2961	124	4	d	d	NOUN
admet-2961	124	5	nd	nd	NOUN
admet-2961	124	6	[	[	X
admet-2961	124	7	63	63	NUM
admet-2961	124	8	]	]	SYM
admet-2961	124	9	m15	m15	NOUN
admet-2961	124	10	7.19	7.19	NUM
admet-2961	124	11	444.1864	444.1864	NUM
admet-2961	124	12	444.1875	444.1875	NUM
admet-2961	124	13	2.5	2.5	NUM
admet-2961	124	14	n	n	CCONJ
admet-2961	124	15	-	-	PUNCT
admet-2961	124	16	dealkylation	dealkylation	NOUN
admet-2961	124	17	,	,	PUNCT
admet-2961	124	18	acetylation	acetylation	NOUN
admet-2961	124	19	and	and	CCONJ
admet-2961	124	20	glucuronidation	glucuronidation	NOUN
admet-2961	124	21	d	d	PROPN
admet-2961	124	22	nd	nd	ADV
admet-2961	124	23	0.5	0.5	NUM
admet-2961	124	24	0.2	0.2	NUM
admet-2961	124	25	nd	nd	NOUN
admet-2961	124	26	m16	m16	NOUN
admet-2961	124	27	7.27	7.27	NUM
admet-2961	124	28	282.1700	282.1700	NUM
admet-2961	124	29	282.1709	282.1709	NUM
admet-2961	124	30	3.2	3.2	NUM
admet-2961	124	31	mono	mono	NOUN
admet-2961	124	32	-	-	PUNCT
admet-2961	124	33	oxygenation	oxygenation	NOUN
admet-2961	124	34	and	and	CCONJ
admet-2961	124	35	dehydrogenation	dehydrogenation	NOUN
admet-2961	124	36	1.3	1.3	NUM
admet-2961	124	37	0.1	0.1	NUM
admet-2961	124	38	d	d	NOUN
admet-2961	124	39	d	d	SYM
admet-2961	124	40	0.5	0.5	NUM
admet-2961	124	41	m17	m17	NOUN
admet-2961	124	42	7.36	7.36	NUM
admet-2961	124	43	268.1543	268.1543	NUM
admet-2961	124	44	268.1551	268.1551	NUM
admet-2961	124	45	3.0	3.0	NUM
admet-2961	124	46	oxidation	oxidation	NOUN
admet-2961	124	47	57.2	57.2	NUM
admet-2961	124	48	19.9	19.9	NUM
admet-2961	124	49	82.6	82.6	NUM
admet-2961	124	50	14.6	14.6	NUM
admet-2961	124	51	18.3	18.3	NUM
admet-2961	124	52	[	[	X
admet-2961	124	53	57	57	NUM
admet-2961	124	54	]	]	PUNCT
admet-2961	124	55	m18	m18	PROPN
admet-2961	124	56	7.80	7.80	NUM
admet-2961	124	57	226.1438	226.1438	NUM
admet-2961	124	58	226.1443	226.1443	NUM
admet-2961	124	59	2.2	2.2	NUM
admet-2961	124	60	n	n	CCONJ
admet-2961	124	61	-	-	PUNCT
admet-2961	124	62	dealkylation	dealkylation	NOUN
admet-2961	124	63	0.1	0.1	NUM
admet-2961	124	64	5.8	5.8	NUM
admet-2961	124	65	d	d	NOUN
admet-2961	124	66	d	d	ADP
admet-2961	124	67	6.4	6.4	NUM
admet-2961	124	68	[	[	X
admet-2961	124	69	69	69	NUM
admet-2961	124	70	]	]	PUNCT
admet-2961	124	71	m19	m19	PROPN
admet-2961	124	72	10.16	10.16	NUM
admet-2961	124	73	444.2228	444.2228	NUM
admet-2961	125	1	444.2236	444.2236	NUM
admet-2961	125	2	1.8	1.8	NUM
admet-2961	125	3	glucuronidation	glucuronidation	NOUN
admet-2961	125	4	d	d	PROPN
admet-2961	125	5	d	d	PROPN
admet-2961	125	6	4.2	4.2	NUM
admet-2961	125	7	0.7	0.7	NUM
admet-2961	125	8	nd	nd	NOUN
admet-2961	125	9	p	p	NOUN
admet-2961	125	10	10.66	10.66	NUM
admet-2961	125	11	268.1907	268.1907	NUM
admet-2961	125	12	268.1914	268.1914	NUM
admet-2961	125	13	2.6	2.6	NUM
admet-2961	125	14	2.1	2.1	NUM
admet-2961	125	15	42.5	42.5	NUM
admet-2961	125	16	1.2	1.2	NUM
admet-2961	125	17	75.8	75.8	NUM
admet-2961	125	18	nd	nd	NUM
admet-2961	125	19	m20	m20	NOUN
admet-2961	125	20	12.52	12.52	NUM
admet-2961	125	21	460.2177	460.2177	NUM
admet-2961	125	22	460.2189	460.2189	NUM
admet-2961	125	23	2.6	2.6	NUM
admet-2961	125	24	mono	mono	NOUN
admet-2961	125	25	-	-	PUNCT
admet-2961	125	26	oxygenation	oxygenation	NOUN
admet-2961	125	27	and	and	CCONJ
admet-2961	125	28	glucuronidation	glucuronidation	NOUN
admet-2961	125	29	nd	nd	ADP
admet-2961	125	30	0.1	0.1	NUM
admet-2961	125	31	d	d	NOUN
admet-2961	125	32	nd	nd	INTJ
admet-2961	125	33	nd	nd	NOUN
admet-2961	125	34	m21	m21	PROPN
admet-2961	125	35	13.05	13.05	NUM
admet-2961	125	36	258.1336	258.1336	NUM
admet-2961	125	37	258.1340	258.1340	NUM
admet-2961	125	38	1.5	1.5	NUM
admet-2961	125	39	n	n	CCONJ
admet-2961	125	40	-	-	PUNCT
admet-2961	125	41	dealkylation	dealkylation	NOUN
admet-2961	125	42	and	and	CCONJ
admet-2961	125	43	dioxygenation	dioxygenation	NOUN
admet-2961	126	1	0.1	0.1	NUM
admet-2961	126	2	0.2	0.2	NUM
admet-2961	126	3	d	d	PROPN
admet-2961	127	1	d	d	PROPN
admet-2961	127	2	nd	nd	NOUN
admet-2961	127	3	m22	m22	PROPN
admet-2961	127	4	13.52	13.52	NUM
admet-2961	127	5	460.2177	460.2177	NUM
admet-2961	127	6	460.2189	460.2189	NUM
admet-2961	127	7	2.6	2.6	NUM
admet-2961	127	8	mono	mono	NOUN
admet-2961	127	9	-	-	PUNCT
admet-2961	127	10	oxygenation	oxygenation	NOUN
admet-2961	127	11	and	and	CCONJ
admet-2961	127	12	glucuronidation	glucuronidation	NOUN
admet-2961	127	13	nd	nd	NOUN
admet-2961	127	14	d	d	NOUN
admet-2961	127	15	0.1	0.1	NUM
admet-2961	127	16	nd	nd	PRON
admet-2961	127	17	nd	nd	NOUN
admet-2961	127	18	i	i	PROPN
admet-2961	127	19	d	d	NOUN
admet-2961	127	20	identity	identity	NOUN
admet-2961	127	21	;	;	PUNCT
admet-2961	127	22	rt	rt	NUM
admet-2961	127	23	–	–	PUNCT
admet-2961	127	24	retention	retention	NOUN
admet-2961	127	25	time	time	NOUN
admet-2961	127	26	;	;	PUNCT
admet-2961	127	27	me	i	PRON
admet-2961	127	28	mass	mass	NOUN
admet-2961	127	29	error	error	NOUN
admet-2961	127	30	;	;	PUNCT
admet-2961	127	31	2d6a	2d6a	NOUN
admet-2961	127	32	recombinant	recombinant	ADJ
admet-2961	127	33	2d6	2d6	NUM
admet-2961	127	34	enzymes	enzyme	NOUN
admet-2961	127	35	;	;	PUNCT
admet-2961	127	36	d	d	NUM
admet-2961	127	37	detected	detect	VERB
admet-2961	127	38	in	in	ADP
admet-2961	127	39	trace	trace	NOUN
admet-2961	127	40	amount	amount	NOUN
admet-2961	127	41	;	;	PUNCT
admet-2961	127	42	nd	nd	ADV
admet-2961	127	43	not	not	PART
admet-2961	127	44	detected	detect	VERB
admet-2961	127	45	;	;	PUNCT
admet-2961	127	46	r	r	NOUN
admet-2961	127	47	-rat	-rat	NOUN
admet-2961	127	48	;	;	PUNCT
admet-2961	127	49	d	d	X
admet-2961	127	50	-dog	-dog	NOUN
admet-2961	127	51	;	;	PUNCT
admet-2961	127	52	mk	mk	NOUN
admet-2961	127	53	monkey	monkey	NOUN
admet-2961	127	54	;	;	PUNCT
admet-2961	127	55	h	h	NOUN
admet-2961	127	56	human	human	NOUN
admet-2961	127	57	.	.	PUNCT
admet-2961	128	1	the	the	DET
admet-2961	128	2	relative	relative	ADJ
admet-2961	128	3	peak	peak	PROPN
admet-2961	128	4	area	area	NOUN
admet-2961	128	5	abundance	abundance	NOUN
admet-2961	128	6	of	of	ADP
admet-2961	128	7	the	the	DET
admet-2961	128	8	parent	parent	NOUN
admet-2961	128	9	and	and	CCONJ
admet-2961	128	10	metabolite	metabolite	NOUN
admet-2961	128	11	was	be	AUX
admet-2961	128	12	calculated	calculate	VERB
admet-2961	128	13	based	base	VERB
admet-2961	128	14	on	on	ADP
admet-2961	128	15	their	their	PRON
admet-2961	128	16	selected	select	VERB
admet-2961	128	17	ion	ion	NOUN
admet-2961	128	18	chromatographic	chromatographic	ADJ
admet-2961	128	19	peak	peak	NOUN
admet-2961	128	20	areas	area	NOUN
admet-2961	128	21	.	.	PUNCT
admet-2961	129	1	figure	figure	VERB
admet-2961	129	2	4	4	NUM
admet-2961	129	3	.	.	NUM
admet-2961	129	4	selected	select	VERB
admet-2961	129	5	ion	ion	NOUN
admet-2961	129	6	chromatograms	chromatogram	NOUN
admet-2961	129	7	of	of	ADP
admet-2961	129	8	metoprolol	metoprolol	NOUN
admet-2961	129	9	and	and	CCONJ
admet-2961	129	10	its	its	PRON
admet-2961	129	11	metabolites	metabolite	NOUN
admet-2961	129	12	in	in	ADP
admet-2961	129	13	plateable	plateable	ADJ
admet-2961	129	14	human	human	NOUN
admet-2961	129	15	(	(	PUNCT
admet-2961	129	16	a	a	NOUN
admet-2961	129	17	)	)	PUNCT
admet-2961	129	18	,	,	PUNCT
admet-2961	129	19	monkey	monkey	NOUN
admet-2961	129	20	(	(	PUNCT
admet-2961	129	21	b	b	NOUN
admet-2961	129	22	)	)	PUNCT
admet-2961	129	23	,	,	PUNCT
admet-2961	129	24	dog	dog	NOUN
admet-2961	129	25	(	(	PUNCT
admet-2961	129	26	c	c	NOUN
admet-2961	129	27	)	)	PUNCT
admet-2961	129	28	and	and	CCONJ
admet-2961	129	29	rat	rat	NOUN
admet-2961	129	30	(	(	PUNCT
admet-2961	129	31	d	d	NOUN
admet-2961	129	32	)	)	PUNCT
admet-2961	129	33	hepatocytes	hepatocytes	PROPN
admet-2961	129	34	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	129	35	j.	j.	PROPN
admet-2961	129	36	pu	pu	PROPN
admet-2961	129	37	et	et	PROPN
admet-2961	129	38	al	al	PROPN
admet-2961	129	39	.	.	PROPN
admet-2961	129	40	admet	admet	PROPN
admet-2961	129	41	&	&	CCONJ
admet-2961	129	42	dmpk	dmpk	PROPN
admet-2961	129	43	13(5	13(5	NUM
admet-2961	129	44	)	)	PUNCT
admet-2961	129	45	(	(	PUNCT
admet-2961	129	46	2025	2025	NUM
admet-2961	129	47	)	)	PUNCT
admet-2961	129	48	2961	2961	NUM
admet-2961	129	49	8	8	NUM
admet-2961	129	50	in	in	ADP
admet-2961	129	51	rat	rat	NOUN
admet-2961	129	52	hepatocytes	hepatocyte	NOUN
admet-2961	129	53	,	,	PUNCT
admet-2961	129	54	m10	m10	PROPN
admet-2961	129	55	and	and	CCONJ
admet-2961	129	56	m17	m17	PROPN
admet-2961	129	57	predominated	predominate	VERB
admet-2961	129	58	,	,	PUNCT
admet-2961	129	59	constituting	constitute	VERB
admet-2961	129	60	24.4	24.4	NUM
admet-2961	129	61	and	and	CCONJ
admet-2961	129	62	57.2	57.2	NUM
admet-2961	129	63	%	%	NOUN
admet-2961	129	64	of	of	ADP
admet-2961	129	65	the	the	DET
admet-2961	129	66	total	total	ADJ
admet-2961	129	67	mass	mass	PROPN
admet-2961	129	68	abundance	abundance	NOUN
admet-2961	129	69	,	,	PUNCT
admet-2961	129	70	respectively	respectively	ADV
admet-2961	129	71	.	.	PUNCT
admet-2961	130	1	in	in	ADP
admet-2961	130	2	dog	dog	NOUN
admet-2961	130	3	hepatocytes	hepatocyte	NOUN
admet-2961	130	4	,	,	PUNCT
admet-2961	130	5	m13	m13	NOUN
admet-2961	130	6	and	and	CCONJ
admet-2961	130	7	m17	m17	PROPN
admet-2961	130	8	were	be	AUX
admet-2961	130	9	the	the	DET
admet-2961	130	10	major	major	ADJ
admet-2961	130	11	metabolites	metabolite	NOUN
admet-2961	130	12	,	,	PUNCT
admet-2961	130	13	accounting	account	VERB
admet-2961	130	14	for	for	ADP
admet-2961	130	15	20.5	20.5	NUM
admet-2961	130	16	and	and	CCONJ
admet-2961	130	17	19.9	19.9	NUM
admet-2961	130	18	%	%	NOUN
admet-2961	130	19	.	.	PUNCT
admet-2961	131	1	notably	notably	ADV
admet-2961	131	2	,	,	PUNCT
admet-2961	131	3	in	in	ADP
admet-2961	131	4	monkey	monkey	NOUN
admet-2961	131	5	and	and	CCONJ
admet-2961	131	6	human	human	ADJ
admet-2961	131	7	hepatocytes	hepatocyte	NOUN
admet-2961	131	8	,	,	PUNCT
admet-2961	131	9	m17	m17	PROPN
admet-2961	131	10	was	be	AUX
admet-2961	131	11	the	the	DET
admet-2961	131	12	dominant	dominant	ADJ
admet-2961	131	13	metabolite	metabolite	NOUN
admet-2961	131	14	,	,	PUNCT
admet-2961	131	15	representing	represent	VERB
admet-2961	131	16	82.6	82.6	NUM
admet-2961	131	17	and	and	CCONJ
admet-2961	131	18	14.6	14.6	NUM
admet-2961	131	19	%	%	NOUN
admet-2961	131	20	of	of	ADP
admet-2961	131	21	the	the	DET
admet-2961	131	22	total	total	ADJ
admet-2961	131	23	mass	mass	PROPN
admet-2961	131	24	abundance	abundance	NOUN
admet-2961	131	25	,	,	PUNCT
admet-2961	131	26	respectively	respectively	ADV
admet-2961	131	27	.	.	PUNCT
admet-2961	132	1	according	accord	VERB
admet-2961	132	2	to	to	ADP
admet-2961	132	3	the	the	DET
admet-2961	132	4	metabolite	metabolite	NOUN
admet-2961	132	5	identification	identification	NOUN
admet-2961	132	6	result	result	NOUN
admet-2961	132	7	in	in	ADP
admet-2961	132	8	recombinant	recombinant	ADJ
admet-2961	132	9	cyp2d6	cyp2d6	NOUN
admet-2961	132	10	enzymes	enzyme	NOUN
admet-2961	132	11	,	,	PUNCT
admet-2961	132	12	the	the	DET
admet-2961	132	13	most	most	ADV
admet-2961	132	14	abundant	abundant	ADJ
admet-2961	132	15	metabolites	metabolite	NOUN
admet-2961	132	16	were	be	AUX
admet-2961	132	17	m1	m1	NOUN
admet-2961	132	18	,	,	PUNCT
admet-2961	132	19	m10	m10	PROPN
admet-2961	132	20	,	,	PUNCT
admet-2961	132	21	m13	m13	NOUN
admet-2961	132	22	,	,	PUNCT
admet-2961	132	23	and	and	CCONJ
admet-2961	132	24	m17	m17	PROPN
admet-2961	132	25	,	,	PUNCT
admet-2961	132	26	with	with	ADP
admet-2961	132	27	relative	relative	ADJ
admet-2961	132	28	abundances	abundance	NOUN
admet-2961	132	29	of	of	ADP
admet-2961	132	30	26.6	26.6	NUM
admet-2961	132	31	,	,	PUNCT
admet-2961	132	32	20.1	20.1	NUM
admet-2961	132	33	,	,	PUNCT
admet-2961	132	34	22.8	22.8	NUM
admet-2961	132	35	and	and	CCONJ
admet-2961	132	36	18.3	18.3	NUM
admet-2961	132	37	%	%	NOUN
admet-2961	132	38	,	,	PUNCT
admet-2961	132	39	respectively	respectively	ADV
admet-2961	132	40	.	.	PUNCT
admet-2961	133	1	across	across	ADP
admet-2961	133	2	all	all	DET
admet-2961	133	3	tested	test	VERB
admet-2961	133	4	species	specie	NOUN
admet-2961	133	5	and	and	CCONJ
admet-2961	133	6	matrices	matrix	NOUN
admet-2961	133	7	,	,	PUNCT
admet-2961	133	8	the	the	DET
admet-2961	133	9	major	major	ADJ
admet-2961	133	10	metabolic	metabolic	NOUN
admet-2961	133	11	pathways	pathway	NOUN
admet-2961	133	12	consisted	consist	VERB
admet-2961	133	13	of	of	ADP
admet-2961	133	14	mono	mono	NOUN
admet-2961	133	15	-	-	PUNCT
admet-2961	133	16	oxygenation	oxygenation	NOUN
admet-2961	133	17	,	,	PUNCT
admet-2961	133	18	o	o	NOUN
admet-2961	133	19	-	-	NOUN
admet-2961	133	20	demethylation	demethylation	NOUN
admet-2961	133	21	,	,	PUNCT
admet-2961	133	22	and	and	CCONJ
admet-2961	133	23	oxidation	oxidation	NOUN
admet-2961	133	24	,	,	PUNCT
admet-2961	133	25	with	with	ADP
admet-2961	133	26	cyp2d6	cyp2d6	NOUN
admet-2961	133	27	confirmed	confirm	VERB
admet-2961	133	28	as	as	ADP
admet-2961	133	29	the	the	DET
admet-2961	133	30	principal	principal	ADJ
admet-2961	133	31	enzyme	enzyme	NOUN
admet-2961	133	32	mediating	mediate	VERB
admet-2961	133	33	these	these	DET
admet-2961	133	34	biotransformations	biotransformation	NOUN
admet-2961	133	35	as	as	SCONJ
admet-2961	133	36	shown	show	VERB
admet-2961	133	37	in	in	ADP
admet-2961	133	38	figure	figure	NOUN
admet-2961	133	39	5	5	NUM
admet-2961	133	40	.	.	PUNCT
admet-2961	133	41	figure	figure	NOUN
admet-2961	133	42	5	5	NUM
admet-2961	133	43	.	.	PUNCT
admet-2961	133	44	proposed	propose	VERB
admet-2961	133	45	metabolic	metabolic	NOUN
admet-2961	133	46	pathways	pathway	NOUN
admet-2961	133	47	of	of	ADP
admet-2961	133	48	metoprolol	metoprolol	PROPN
admet-2961	133	49	in	in	ADP
admet-2961	133	50	plated	plate	VERB
admet-2961	133	51	hepatocytes	hepatocyte	NOUN
admet-2961	133	52	and	and	CCONJ
admet-2961	133	53	cyp2d6	cyp2d6	NOUN
admet-2961	133	54	recombinant	recombinant	ADJ
admet-2961	133	55	enzymes	enzyme	NOUN
admet-2961	133	56	metabolites	metabolite	NOUN
admet-2961	133	57	elucidation	elucidation	NOUN
admet-2961	133	58	metabolite	metabolite	NOUN
admet-2961	133	59	structures	structure	NOUN
admet-2961	133	60	were	be	AUX
admet-2961	133	61	deduced	deduce	VERB
admet-2961	133	62	based	base	VERB
admet-2961	133	63	on	on	ADP
admet-2961	133	64	mass	mass	ADJ
admet-2961	133	65	defect	defect	NOUN
admet-2961	133	66	analysis	analysis	NOUN
admet-2961	133	67	and	and	CCONJ
admet-2961	133	68	fragmentation	fragmentation	NOUN
admet-2961	133	69	patterns	pattern	NOUN
admet-2961	133	70	.	.	PUNCT
admet-2961	134	1	oxygenation	oxygenation	NOUN
admet-2961	134	2	derivatives	derivative	NOUN
admet-2961	134	3	m10	m10	PROPN
admet-2961	134	4	exhibited	exhibit	VERB
admet-2961	134	5	a	a	DET
admet-2961	134	6	protonated	protonate	VERB
admet-2961	134	7	molecular	molecular	ADJ
admet-2961	134	8	ion	ion	NOUN
admet-2961	134	9	at	at	ADP
admet-2961	134	10	m	m	PROPN
admet-2961	134	11	/	/	SYM
admet-2961	134	12	z	z	PROPN
admet-2961	134	13	284.1863	284.1863	NUM
admet-2961	134	14	;	;	PUNCT
admet-2961	134	15	its	its	PRON
admet-2961	134	16	characteristic	characteristic	ADJ
admet-2961	134	17	ions	ion	NOUN
admet-2961	134	18	were	be	AUX
admet-2961	134	19	observed	observe	VERB
admet-2961	134	20	at	at	ADP
admet-2961	134	21	m	m	PROPN
admet-2961	134	22	/	/	SYM
admet-2961	134	23	z	z	PROPN
admet-2961	134	24	56.0500	56.0500	NUM
admet-2961	134	25	,	,	PUNCT
admet-2961	134	26	74.0603	74.0603	NUM
admet-2961	134	27	,	,	PUNCT
admet-2961	134	28	98.0968	98.0968	NUM
admet-2961	134	29	,	,	PUNCT
admet-2961	134	30	116.1074	116.1074	NUM
admet-2961	134	31	,	,	PUNCT
admet-2961	134	32	and	and	CCONJ
admet-2961	134	33	specifically	specifically	ADV
admet-2961	134	34	at	at	ADP
admet-2961	134	35	m	m	PROPN
admet-2961	134	36	/	/	SYM
admet-2961	134	37	z	z	NOUN
admet-2961	134	38	207.1025	207.1025	NUM
admet-2961	134	39	,	,	PUNCT
admet-2961	134	40	indicating	indicate	VERB
admet-2961	134	41	that	that	SCONJ
admet-2961	134	42	m10	m10	PROPN
admet-2961	134	43	was	be	AUX
admet-2961	134	44	a	a	DET
admet-2961	134	45	monooxygenation	monooxygenation	NOUN
admet-2961	134	46	metabolite	metabolite	NOUN
admet-2961	134	47	.	.	PUNCT
admet-2961	135	1	m10	m10	PROPN
admet-2961	135	2	eluted	elute	VERB
admet-2961	135	3	at	at	ADP
admet-2961	135	4	a	a	DET
admet-2961	135	5	retention	retention	NOUN
admet-2961	135	6	time	time	NOUN
admet-2961	135	7	of	of	ADP
admet-2961	135	8	6.55	6.55	NUM
admet-2961	135	9	min	min	NOUN
admet-2961	135	10	,	,	PUNCT
admet-2961	135	11	which	which	PRON
admet-2961	135	12	was	be	AUX
admet-2961	135	13	close	close	ADJ
admet-2961	135	14	to	to	ADP
admet-2961	135	15	that	that	PRON
admet-2961	135	16	of	of	ADP
admet-2961	135	17	α	α	NOUN
admet-2961	135	18	-	-	NOUN
admet-2961	135	19	hydroxymetoprolol	hydroxymetoprolol	NOUN
admet-2961	135	20	.	.	PUNCT
admet-2961	136	1	furthermore	furthermore	ADV
admet-2961	136	2	,	,	PUNCT
admet-2961	136	3	m10	m10	PROPN
admet-2961	136	4	and	and	CCONJ
admet-2961	136	5	α	α	NOUN
admet-2961	136	6	-	-	PUNCT
admet-2961	136	7	hydroxy	hydroxy	VERB
admet-2961	136	8	-	-	PUNCT
admet-2961	136	9	metoprolol	metoprolol	NOUN
admet-2961	136	10	shared	share	VERB
admet-2961	136	11	similar	similar	ADJ
admet-2961	136	12	fragment	fragment	NOUN
admet-2961	136	13	ions	ion	NOUN
admet-2961	136	14	at	at	ADP
admet-2961	136	15	m	m	PROPN
admet-2961	136	16	/	/	SYM
admet-2961	136	17	z	z	NOUN
admet-2961	136	18	74.0600	74.0600	NUM
admet-2961	136	19	,	,	PUNCT
admet-2961	136	20	98.0964	98.0964	NUM
admet-2961	136	21	,	,	PUNCT
admet-2961	136	22	116.1069	116.1069	NUM
admet-2961	136	23	,	,	PUNCT
admet-2961	136	24	133.0647	133.0647	NUM
admet-2961	136	25	and	and	CCONJ
admet-2961	136	26	207.1015	207.1015	NUM
admet-2961	136	27	,	,	PUNCT
admet-2961	136	28	suggesting	suggest	VERB
admet-2961	136	29	they	they	PRON
admet-2961	136	30	were	be	AUX
admet-2961	136	31	closely	closely	ADV
admet-2961	136	32	related	relate	VERB
admet-2961	136	33	.	.	PUNCT
admet-2961	137	1	m16	m16	PROPN
admet-2961	137	2	exhibited	exhibit	VERB
admet-2961	137	3	a	a	DET
admet-2961	137	4	protonated	protonate	VERB
admet-2961	137	5	molecular	molecular	ADJ
admet-2961	137	6	ion	ion	NOUN
admet-2961	137	7	at	at	ADP
admet-2961	137	8	m	m	PROPN
admet-2961	137	9	/	/	SYM
admet-2961	137	10	z	z	PROPN
admet-2961	137	11	282.1709	282.1709	NUM
admet-2961	137	12	,	,	PUNCT
admet-2961	137	13	with	with	ADP
admet-2961	137	14	characteristic	characteristic	ADJ
admet-2961	137	15	ions	ion	NOUN
admet-2961	137	16	at	at	ADP
admet-2961	137	17	m	m	PROPN
admet-2961	137	18	/	/	SYM
admet-2961	137	19	z	z	PROPN
admet-2961	137	20	173.0601	173.0601	NUM
admet-2961	137	21	,	,	PUNCT
admet-2961	137	22	205.0869	205.0869	NUM
admet-2961	137	23	and	and	CCONJ
admet-2961	137	24	240.1228	240.1228	NUM
admet-2961	137	25	,	,	PUNCT
admet-2961	137	26	indicating	indicate	VERB
admet-2961	137	27	that	that	SCONJ
admet-2961	137	28	m16	m16	PROPN
admet-2961	137	29	was	be	AUX
admet-2961	137	30	a	a	DET
admet-2961	137	31	metabolite	metabolite	NOUN
admet-2961	137	32	of	of	ADP
admet-2961	137	33	mono	mono	NOUN
admet-2961	137	34	-	-	PUNCT
admet-2961	137	35	oxygenation	oxygenation	NOUN
admet-2961	137	36	and	and	CCONJ
admet-2961	137	37	dehydrogenation	dehydrogenation	NOUN
admet-2961	137	38	.	.	PUNCT
admet-2961	138	1	o	o	NOUN
admet-2961	138	2	-	-	PUNCT
admet-2961	138	3	demethylation	demethylation	NOUN
admet-2961	138	4	products	product	NOUN
admet-2961	138	5	m13	m13	NOUN
admet-2961	138	6	exhibited	exhibit	VERB
admet-2961	138	7	a	a	DET
admet-2961	138	8	protonated	protonate	VERB
admet-2961	138	9	molecular	molecular	ADJ
admet-2961	138	10	ion	ion	NOUN
admet-2961	138	11	at	at	ADP
admet-2961	138	12	m	m	PROPN
admet-2961	138	13	/	/	SYM
admet-2961	138	14	z	z	PROPN
admet-2961	138	15	254.1755	254.1755	NUM
admet-2961	138	16	,	,	PUNCT
admet-2961	138	17	with	with	ADP
admet-2961	138	18	characteristic	characteristic	ADJ
admet-2961	138	19	ions	ion	NOUN
admet-2961	138	20	at	at	ADP
admet-2961	138	21	m	m	PROPN
admet-2961	138	22	/	/	SYM
admet-2961	138	23	z	z	PROPN
admet-2961	138	24	116.1072	116.1072	NUM
admet-2961	138	25	,	,	PUNCT
admet-2961	138	26	159.0808	159.0808	NUM
admet-2961	138	27	and	and	CCONJ
admet-2961	138	28	177.0914	177.0914	NUM
admet-2961	138	29	,	,	PUNCT
admet-2961	138	30	indicating	indicate	VERB
admet-2961	138	31	that	that	SCONJ
admet-2961	138	32	m13	m13	PROPN
admet-2961	138	33	was	be	AUX
admet-2961	138	34	an	an	DET
admet-2961	138	35	o	o	NOUN
admet-2961	138	36	-	-	NOUN
admet-2961	138	37	demethylation	demethylation	NOUN
admet-2961	138	38	metabolite	metabolite	NOUN
admet-2961	138	39	.	.	PUNCT
admet-2961	139	1	m1	m1	PROPN
admet-2961	139	2	and	and	CCONJ
admet-2961	139	3	m8	m8	PROPN
admet-2961	139	4	displayed	display	VERB
admet-2961	139	5	the	the	DET
admet-2961	139	6	same	same	ADJ
admet-2961	139	7	protonated	protonate	VERB
admet-2961	139	8	molecular	molecular	ADJ
admet-2961	139	9	ion	ion	NOUN
admet-2961	139	10	at	at	ADP
admet-2961	139	11	m	m	PROPN
admet-2961	139	12	/	/	SYM
admet-2961	139	13	z	z	PROPN
admet-2961	139	14	270.171	270.171	NUM
admet-2961	139	15	,	,	PUNCT
admet-2961	139	16	along	along	ADP
admet-2961	139	17	with	with	ADP
admet-2961	139	18	identical	identical	ADJ
admet-2961	139	19	characteristic	characteristic	ADJ
admet-2961	139	20	ions	ion	NOUN
admet-2961	139	21	at	at	ADP
admet-2961	139	22	m	m	PROPN
admet-2961	139	23	/	/	SYM
admet-2961	139	24	z	z	PROPN
admet-2961	139	25	175.0760	175.0760	NUM
admet-2961	139	26	and	and	CCONJ
admet-2961	139	27	193.0866	193.0866	NUM
admet-2961	139	28	,	,	PUNCT
admet-2961	139	29	suggesting	suggest	VERB
admet-2961	139	30	a	a	DET
admet-2961	139	31	mono	mono	NOUN
admet-2961	139	32	-	-	PUNCT
admet-2961	139	33	oxygenation	oxygenation	NOUN
admet-2961	139	34	reaction	reaction	NOUN
admet-2961	139	35	on	on	ADP
admet-2961	139	36	m13	m13	PROPN
admet-2961	139	37	.	.	PUNCT
admet-2961	140	1	admet	admet	PROPN
admet-2961	140	2	&	&	CCONJ
admet-2961	140	3	dmpk	dmpk	PROPN
admet-2961	140	4	16(5	16(5	NUM
admet-2961	140	5	)	)	PUNCT
admet-2961	140	6	(	(	PUNCT
admet-2961	140	7	2025	2025	NUM
admet-2961	140	8	)	)	PUNCT
admet-2961	140	9	2961	2961	NUM
admet-2961	140	10	natural	natural	ADJ
admet-2961	140	11	molecules	molecule	NOUN
admet-2961	140	12	for	for	ADP
admet-2961	140	13	emt	emt	PROPN
admet-2961	140	14	treatment	treatment	NOUN
admet-2961	140	15	doi	doi	NOUN
admet-2961	140	16	:	:	PUNCT
admet-2961	140	17	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	ADJ
admet-2961	140	18	9	9	NUM
admet-2961	140	19	m3	m3	PROPN
admet-2961	140	20	presented	present	VERB
admet-2961	140	21	a	a	DET
admet-2961	140	22	protonated	protonate	VERB
admet-2961	140	23	molecular	molecular	ADJ
admet-2961	140	24	ion	ion	NOUN
admet-2961	140	25	at	at	ADP
admet-2961	140	26	m	m	PROPN
admet-2961	140	27	/	/	SYM
admet-2961	140	28	z	z	PROPN
admet-2961	140	29	212.1288	212.1288	NUM
admet-2961	140	30	,	,	PUNCT
admet-2961	140	31	with	with	ADP
admet-2961	140	32	characteristic	characteristic	ADJ
admet-2961	140	33	ions	ion	NOUN
admet-2961	140	34	at	at	ADP
admet-2961	140	35	m	m	PROPN
admet-2961	140	36	/	/	SYM
admet-2961	140	37	z	z	PROPN
admet-2961	140	38	74.0603	74.0603	NUM
admet-2961	140	39	,	,	PUNCT
admet-2961	140	40	159.0810	159.0810	NUM
admet-2961	140	41	,	,	PUNCT
admet-2961	140	42	and	and	CCONJ
admet-2961	140	43	177.0915	177.0915	NUM
admet-2961	140	44	.	.	PUNCT
admet-2961	141	1	no	no	DET
admet-2961	141	2	modification	modification	NOUN
admet-2961	141	3	was	be	AUX
admet-2961	141	4	detected	detect	VERB
admet-2961	141	5	on	on	ADP
admet-2961	141	6	the	the	DET
admet-2961	141	7	m	m	PROPN
admet-2961	141	8	/	/	SYM
admet-2961	141	9	z	z	PROPN
admet-2961	141	10	177.0915	177.0915	NUM
admet-2961	141	11	moiety	moiety	NOUN
admet-2961	141	12	,	,	PUNCT
admet-2961	141	13	and	and	CCONJ
admet-2961	141	14	n	n	CCONJ
admet-2961	141	15	-	-	PUNCT
admet-2961	141	16	dealkylation	dealkylation	NOUN
admet-2961	141	17	was	be	AUX
admet-2961	141	18	confirmed	confirm	VERB
admet-2961	141	19	by	by	ADP
admet-2961	141	20	the	the	DET
admet-2961	141	21	indirect	indirect	ADJ
admet-2961	141	22	fragment	fragment	NOUN
admet-2961	141	23	at	at	ADP
admet-2961	141	24	m	m	PROPN
admet-2961	141	25	/	/	SYM
admet-2961	141	26	z	z	PROPN
admet-2961	141	27	74.0603	74.0603	NUM
admet-2961	141	28	,	,	PUNCT
admet-2961	141	29	which	which	PRON
admet-2961	141	30	was	be	AUX
admet-2961	141	31	dealkylated	dealkylate	VERB
admet-2961	141	32	from	from	ADP
admet-2961	141	33	m	m	PROPN
admet-2961	141	34	/	/	SYM
admet-2961	141	35	z	z	PROPN
admet-2961	141	36	116.1072	116.1072	NUM
admet-2961	141	37	,	,	PUNCT
admet-2961	141	38	therefore	therefore	ADV
admet-2961	141	39	,	,	PUNCT
admet-2961	141	40	m3	m3	PROPN
admet-2961	141	41	was	be	AUX
admet-2961	141	42	classified	classify	VERB
admet-2961	141	43	as	as	ADP
admet-2961	141	44	a	a	DET
admet-2961	141	45	metabolite	metabolite	NOUN
admet-2961	141	46	of	of	ADP
admet-2961	141	47	both	both	DET
admet-2961	141	48	o	o	NOUN
admet-2961	141	49	-	-	NOUN
admet-2961	141	50	demethylation	demethylation	NOUN
admet-2961	141	51	and	and	CCONJ
admet-2961	141	52	n	n	CCONJ
admet-2961	141	53	-	-	PUNCT
admet-2961	141	54	dealkylation	dealkylation	NOUN
admet-2961	141	55	.	.	PUNCT
admet-2961	142	1	m5	m5	NOUN
admet-2961	142	2	displayed	display	VERB
admet-2961	142	3	a	a	DET
admet-2961	142	4	protonated	protonate	VERB
admet-2961	142	5	molecular	molecular	ADJ
admet-2961	142	6	ion	ion	NOUN
admet-2961	142	7	at	at	ADP
admet-2961	142	8	m	m	PROPN
admet-2961	142	9	/	/	SYM
admet-2961	142	10	z	z	NOUN
admet-2961	142	11	268.1552	268.1552	NUM
admet-2961	142	12	,	,	PUNCT
admet-2961	142	13	with	with	ADP
admet-2961	142	14	characteristic	characteristic	ADJ
admet-2961	142	15	ions	ion	NOUN
admet-2961	142	16	at	at	ADP
admet-2961	142	17	m	m	PROPN
admet-2961	142	18	/	/	SYM
admet-2961	142	19	z	z	PROPN
admet-2961	142	20	116.1074	116.1074	NUM
admet-2961	142	21	,	,	PUNCT
admet-2961	142	22	191.0708	191.0708	NUM
admet-2961	142	23	,	,	PUNCT
admet-2961	142	24	and	and	CCONJ
admet-2961	142	25	226.1079	226.1079	NUM
admet-2961	142	26	.	.	PUNCT
admet-2961	143	1	no	no	DET
admet-2961	143	2	modification	modification	NOUN
admet-2961	143	3	was	be	AUX
admet-2961	143	4	detected	detect	VERB
admet-2961	143	5	on	on	ADP
admet-2961	143	6	the	the	DET
admet-2961	143	7	m	m	PROPN
admet-2961	143	8	/	/	SYM
admet-2961	143	9	z	z	PROPN
admet-2961	143	10	116.1074	116.1074	NUM
admet-2961	143	11	moiety	moiety	NOUN
admet-2961	143	12	,	,	PUNCT
admet-2961	143	13	while	while	SCONJ
admet-2961	143	14	dehydrogenation	dehydrogenation	NOUN
admet-2961	143	15	was	be	AUX
admet-2961	143	16	observed	observe	VERB
admet-2961	143	17	on	on	ADP
admet-2961	143	18	the	the	DET
admet-2961	143	19	moieties	moiety	NOUN
admet-2961	143	20	at	at	ADP
admet-2961	143	21	m	m	PROPN
admet-2961	143	22	/	/	SYM
admet-2961	143	23	z	z	PROPN
admet-2961	143	24	191.0708	191.0708	NUM
admet-2961	143	25	and	and	CCONJ
admet-2961	143	26	m	m	PROPN
admet-2961	143	27	/	/	SYM
admet-2961	143	28	z	z	PROPN
admet-2961	143	29	226.1079	226.1079	NUM
admet-2961	143	30	compared	compare	VERB
admet-2961	143	31	to	to	ADP
admet-2961	143	32	m1	m1	PROPN
admet-2961	143	33	or	or	CCONJ
admet-2961	143	34	m8	m8	PROPN
admet-2961	143	35	,	,	PUNCT
admet-2961	143	36	therefore	therefore	ADV
admet-2961	143	37	,	,	PUNCT
admet-2961	143	38	m5	m5	PROPN
admet-2961	143	39	was	be	AUX
admet-2961	143	40	identified	identify	VERB
admet-2961	143	41	as	as	ADP
admet-2961	143	42	a	a	DET
admet-2961	143	43	dehydrogenation	dehydrogenation	NOUN
admet-2961	143	44	metabolite	metabolite	NOUN
admet-2961	143	45	from	from	ADP
admet-2961	143	46	m1	m1	PROPN
admet-2961	143	47	or	or	CCONJ
admet-2961	143	48	m8	m8	PROPN
admet-2961	143	49	.	.	PROPN
admet-2961	144	1	oxidative	oxidative	ADJ
admet-2961	144	2	transformations	transformation	NOUN
admet-2961	144	3	m9	m9	PROPN
admet-2961	144	4	exhibited	exhibit	VERB
admet-2961	144	5	a	a	DET
admet-2961	144	6	protonated	protonate	VERB
admet-2961	144	7	molecular	molecular	ADJ
admet-2961	144	8	ion	ion	NOUN
admet-2961	144	9	at	at	ADP
admet-2961	144	10	m	m	PROPN
admet-2961	144	11	/	/	SYM
admet-2961	144	12	z	z	PROPN
admet-2961	144	13	254.1395	254.1395	NUM
admet-2961	144	14	,	,	PUNCT
admet-2961	144	15	its	its	PRON
admet-2961	144	16	characteristic	characteristic	ADJ
admet-2961	144	17	ions	ion	NOUN
admet-2961	144	18	were	be	AUX
admet-2961	144	19	observed	observe	VERB
admet-2961	144	20	at	at	ADP
admet-2961	144	21	m	m	PROPN
admet-2961	144	22	/	/	SYM
admet-2961	144	23	z	z	PROPN
admet-2961	144	24	116.1075	116.1075	NUM
admet-2961	144	25	,	,	PUNCT
admet-2961	144	26	151.0396	151.0396	NUM
admet-2961	144	27	,	,	PUNCT
admet-2961	144	28	133.0653	133.0653	NUM
admet-2961	144	29	,	,	PUNCT
admet-2961	144	30	and	and	CCONJ
admet-2961	144	31	177.0553	177.0553	NUM
admet-2961	144	32	,	,	PUNCT
admet-2961	144	33	indicating	indicate	VERB
admet-2961	144	34	that	that	SCONJ
admet-2961	144	35	m9	m9	PROPN
admet-2961	144	36	was	be	AUX
admet-2961	144	37	an	an	DET
admet-2961	144	38	oxidation	oxidation	NOUN
admet-2961	144	39	metabolite	metabolite	NOUN
admet-2961	144	40	.	.	PUNCT
admet-2961	145	1	m17	m17	PROPN
admet-2961	145	2	exhibited	exhibit	VERB
admet-2961	145	3	a	a	DET
admet-2961	145	4	protonated	protonate	VERB
admet-2961	145	5	molecular	molecular	ADJ
admet-2961	145	6	ion	ion	NOUN
admet-2961	145	7	at	at	ADP
admet-2961	145	8	m	m	PROPN
admet-2961	145	9	/	/	SYM
admet-2961	145	10	z	z	PROPN
admet-2961	145	11	268.1551	268.1551	NUM
admet-2961	145	12	,	,	PUNCT
admet-2961	145	13	its	its	PRON
admet-2961	145	14	characteristic	characteristic	ADJ
admet-2961	145	15	ions	ion	NOUN
admet-2961	145	16	were	be	AUX
admet-2961	145	17	observed	observe	VERB
admet-2961	145	18	at	at	ADP
admet-2961	145	19	m	m	PROPN
admet-2961	145	20	/	/	SYM
admet-2961	145	21	z	z	NOUN
admet-2961	145	22	116.1073	116.1073	NUM
admet-2961	145	23	,	,	PUNCT
admet-2961	145	24	145.0653	145.0653	NUM
admet-2961	145	25	,	,	PUNCT
admet-2961	145	26	191.0708	191.0708	NUM
admet-2961	145	27	,	,	PUNCT
admet-2961	145	28	and	and	CCONJ
admet-2961	145	29	226.1082	226.1082	NUM
admet-2961	145	30	.	.	PUNCT
admet-2961	146	1	a	a	DET
admet-2961	146	2	special	special	ADJ
admet-2961	146	3	transition	transition	NOUN
admet-2961	146	4	of	of	ADP
admet-2961	146	5	loss	loss	NOUN
admet-2961	146	6	of	of	ADP
admet-2961	146	7	carboxyl	carboxyl	NOUN
admet-2961	146	8	group	group	NOUN
admet-2961	146	9	from	from	ADP
admet-2961	146	10	m	m	PROPN
admet-2961	146	11	/	/	SYM
admet-2961	146	12	z	z	PROPN
admet-2961	146	13	191.0708	191.0708	NUM
admet-2961	146	14	to	to	ADP
admet-2961	146	15	m	m	PROPN
admet-2961	146	16	/	/	SYM
admet-2961	146	17	z	z	PROPN
admet-2961	146	18	145.0653	145.0653	NUM
admet-2961	146	19	suggested	suggest	VERB
admet-2961	146	20	that	that	SCONJ
admet-2961	146	21	m17	m17	PROPN
admet-2961	146	22	was	be	AUX
admet-2961	146	23	an	an	DET
admet-2961	146	24	oxidation	oxidation	NOUN
admet-2961	146	25	metabolite	metabolite	NOUN
admet-2961	146	26	.	.	PUNCT
admet-2961	147	1	furthermore	furthermore	ADV
admet-2961	147	2	,	,	PUNCT
admet-2961	147	3	m17	m17	PROPN
admet-2961	147	4	was	be	AUX
admet-2961	147	5	eluted	elute	VERB
admet-2961	147	6	at	at	ADP
admet-2961	147	7	a	a	DET
admet-2961	147	8	retention	retention	NOUN
admet-2961	147	9	time	time	NOUN
admet-2961	147	10	of	of	ADP
admet-2961	147	11	7.52	7.52	NUM
admet-2961	147	12	min	min	NOUN
admet-2961	147	13	,	,	PUNCT
admet-2961	147	14	which	which	PRON
admet-2961	147	15	was	be	AUX
admet-2961	147	16	close	close	ADJ
admet-2961	147	17	to	to	ADP
admet-2961	147	18	that	that	PRON
admet-2961	147	19	of	of	ADP
admet-2961	147	20	metoprolol	metoprolol	NOUN
admet-2961	147	21	acid	acid	NOUN
admet-2961	147	22	,	,	PUNCT
admet-2961	147	23	and	and	CCONJ
admet-2961	147	24	they	they	PRON
admet-2961	147	25	shared	share	VERB
admet-2961	147	26	similar	similar	ADJ
admet-2961	147	27	fragments	fragment	NOUN
admet-2961	147	28	at	at	ADP
admet-2961	147	29	m	m	PROPN
admet-2961	147	30	/	/	SYM
admet-2961	147	31	z	z	PROPN
admet-2961	147	32	56.0498	56.0498	NUM
admet-2961	147	33	,	,	PUNCT
admet-2961	147	34	98.0964	98.0964	NUM
admet-2961	147	35	,	,	PUNCT
admet-2961	147	36	116.1069	116.1069	NUM
admet-2961	147	37	,	,	PUNCT
admet-2961	147	38	145.0647	145.0647	NUM
admet-2961	147	39	,	,	PUNCT
admet-2961	147	40	191.0701	191.0701	NUM
admet-2961	147	41	,	,	PUNCT
admet-2961	147	42	226.1073	226.1073	NUM
admet-2961	147	43	,	,	PUNCT
admet-2961	147	44	and	and	CCONJ
admet-2961	147	45	250.1437	250.1437	NUM
admet-2961	147	46	.	.	PUNCT
admet-2961	148	1	therefore	therefore	ADV
admet-2961	148	2	,	,	PUNCT
admet-2961	148	3	m17	m17	PROPN
admet-2961	148	4	was	be	AUX
admet-2961	148	5	identified	identify	VERB
admet-2961	148	6	as	as	ADP
admet-2961	148	7	metoprolol	metoprolol	NOUN
admet-2961	148	8	acid	acid	NOUN
admet-2961	148	9	.	.	PUNCT
admet-2961	149	1	m2	m2	PROPN
admet-2961	149	2	displayed	display	VERB
admet-2961	149	3	a	a	DET
admet-2961	149	4	protonated	protonate	VERB
admet-2961	149	5	molecular	molecular	ADJ
admet-2961	149	6	ion	ion	NOUN
admet-2961	149	7	at	at	ADP
admet-2961	149	8	m	m	PROPN
admet-2961	149	9	/	/	SYM
admet-2961	149	10	z	z	NOUN
admet-2961	149	11	284.1503	284.1503	NUM
admet-2961	149	12	,	,	PUNCT
admet-2961	149	13	with	with	ADP
admet-2961	149	14	characteristic	characteristic	ADJ
admet-2961	149	15	ions	ion	NOUN
admet-2961	149	16	at	at	ADP
admet-2961	149	17	m	m	PROPN
admet-2961	149	18	/	/	SYM
admet-2961	149	19	z	z	PROPN
admet-2961	149	20	116.1074	116.1074	NUM
admet-2961	149	21	,	,	PUNCT
admet-2961	149	22	189.0552	189.0552	NUM
admet-2961	149	23	,	,	PUNCT
admet-2961	149	24	and	and	CCONJ
admet-2961	149	25	207.0659	207.0659	NUM
admet-2961	149	26	.	.	PUNCT
admet-2961	150	1	no	no	DET
admet-2961	150	2	modifications	modification	NOUN
admet-2961	150	3	occurred	occur	VERB
admet-2961	150	4	on	on	ADP
admet-2961	150	5	the	the	DET
admet-2961	150	6	m	m	PROPN
admet-2961	150	7	/	/	SYM
admet-2961	150	8	z	z	PROPN
admet-2961	150	9	116.1074	116.1074	NUM
admet-2961	150	10	moiety	moiety	NOUN
admet-2961	150	11	,	,	PUNCT
admet-2961	150	12	suggesting	suggest	VERB
admet-2961	150	13	that	that	SCONJ
admet-2961	150	14	m2	m2	PROPN
admet-2961	150	15	was	be	AUX
admet-2961	150	16	a	a	DET
admet-2961	150	17	mono	mono	NOUN
admet-2961	150	18	-	-	PUNCT
admet-2961	150	19	oxygenation	oxygenation	NOUN
admet-2961	150	20	metabolite	metabolite	NOUN
admet-2961	150	21	originating	originate	VERB
admet-2961	150	22	from	from	ADP
admet-2961	150	23	m17	m17	PROPN
admet-2961	150	24	.	.	PUNCT
admet-2961	151	1	m4	m4	PROPN
admet-2961	151	2	exhibited	exhibit	VERB
admet-2961	151	3	a	a	DET
admet-2961	151	4	protonated	protonate	VERB
admet-2961	151	5	molecular	molecular	ADJ
admet-2961	151	6	ion	ion	NOUN
admet-2961	151	7	at	at	ADP
admet-2961	151	8	m	m	PROPN
admet-2961	151	9	/	/	SYM
admet-2961	151	10	z	z	PROPN
admet-2961	151	11	226.1082	226.1082	NUM
admet-2961	151	12	,	,	PUNCT
admet-2961	151	13	with	with	ADP
admet-2961	151	14	characteristic	characteristic	ADJ
admet-2961	151	15	ions	ion	NOUN
admet-2961	151	16	at	at	ADP
admet-2961	151	17	m	m	PROPN
admet-2961	151	18	/	/	SYM
admet-2961	151	19	z	z	PROPN
admet-2961	151	20	56.0499	56.0499	NUM
admet-2961	151	21	,	,	PUNCT
admet-2961	151	22	74.0603	74.0603	NUM
admet-2961	151	23	,	,	PUNCT
admet-2961	151	24	145.0652	145.0652	NUM
admet-2961	151	25	,	,	PUNCT
admet-2961	151	26	and	and	CCONJ
admet-2961	151	27	191.0709	191.0709	NUM
admet-2961	151	28	.	.	PUNCT
admet-2961	152	1	no	no	DET
admet-2961	152	2	modifications	modification	NOUN
admet-2961	152	3	were	be	AUX
admet-2961	152	4	observed	observe	VERB
admet-2961	152	5	on	on	ADP
admet-2961	152	6	the	the	DET
admet-2961	152	7	m	m	PROPN
admet-2961	152	8	/	/	SYM
admet-2961	152	9	z	z	PROPN
admet-2961	152	10	191.0709	191.0709	NUM
admet-2961	152	11	moiety	moiety	NOUN
admet-2961	152	12	,	,	PUNCT
admet-2961	152	13	indicating	indicate	VERB
admet-2961	152	14	that	that	SCONJ
admet-2961	152	15	m4	m4	PROPN
admet-2961	152	16	was	be	AUX
admet-2961	152	17	an	an	DET
admet-2961	152	18	n	n	NUM
admet-2961	152	19	-	-	PUNCT
admet-2961	152	20	dealkylation	dealkylation	NOUN
admet-2961	152	21	metabolite	metabolite	NOUN
admet-2961	152	22	derived	derive	VERB
admet-2961	152	23	from	from	ADP
admet-2961	152	24	m17	m17	PROPN
admet-2961	152	25	.	.	PUNCT
admet-2961	153	1	n	n	CCONJ
admet-2961	153	2	-	-	PUNCT
admet-2961	153	3	dealkylation	dealkylation	NOUN
admet-2961	153	4	modifications	modification	NOUN
admet-2961	153	5	m18	m18	PROPN
admet-2961	153	6	exhibited	exhibit	VERB
admet-2961	153	7	a	a	DET
admet-2961	153	8	protonated	protonate	VERB
admet-2961	153	9	molecular	molecular	ADJ
admet-2961	153	10	ion	ion	NOUN
admet-2961	153	11	at	at	ADP
admet-2961	153	12	m	m	PROPN
admet-2961	153	13	/	/	SYM
admet-2961	153	14	z	z	NOUN
admet-2961	153	15	226.1443	226.1443	NUM
admet-2961	153	16	,	,	PUNCT
admet-2961	153	17	with	with	ADP
admet-2961	153	18	characteristic	characteristic	ADJ
admet-2961	153	19	ions	ion	NOUN
admet-2961	153	20	at	at	ADP
admet-2961	153	21	m	m	PROPN
admet-2961	153	22	/	/	SYM
admet-2961	153	23	z	z	NOUN
admet-2961	153	24	74.0603	74.0603	NUM
admet-2961	153	25	and	and	CCONJ
admet-2961	153	26	m	m	PROPN
admet-2961	153	27	/	/	SYM
admet-2961	153	28	z	z	PROPN
admet-2961	153	29	191.1072	191.1072	NUM
admet-2961	153	30	.	.	PUNCT
admet-2961	154	1	no	no	DET
admet-2961	154	2	modifications	modification	NOUN
admet-2961	154	3	were	be	AUX
admet-2961	154	4	detected	detect	VERB
admet-2961	154	5	on	on	ADP
admet-2961	154	6	the	the	DET
admet-2961	154	7	m	m	PROPN
admet-2961	154	8	/	/	SYM
admet-2961	154	9	z	z	PROPN
admet-2961	154	10	191.1072	191.1072	NUM
admet-2961	154	11	moiety	moiety	NOUN
admet-2961	154	12	,	,	PUNCT
admet-2961	154	13	and	and	CCONJ
admet-2961	154	14	n	n	CCONJ
admet-2961	154	15	-	-	PUNCT
admet-2961	154	16	dealkylation	dealkylation	NOUN
admet-2961	154	17	was	be	AUX
admet-2961	154	18	confirmed	confirm	VERB
admet-2961	154	19	by	by	ADP
admet-2961	154	20	a	a	DET
admet-2961	154	21	transition	transition	NOUN
admet-2961	154	22	from	from	ADP
admet-2961	154	23	m	m	PROPN
admet-2961	154	24	/	/	SYM
admet-2961	154	25	z	z	PROPN
admet-2961	154	26	116.1072	116.1072	NUM
admet-2961	154	27	to	to	ADP
admet-2961	154	28	m	m	PROPN
admet-2961	154	29	/	/	SYM
admet-2961	154	30	z	z	PROPN
admet-2961	154	31	74.0603	74.0603	NUM
admet-2961	154	32	.	.	PUNCT
admet-2961	155	1	therefore	therefore	ADV
admet-2961	155	2	,	,	PUNCT
admet-2961	155	3	m18	m18	PROPN
admet-2961	155	4	was	be	AUX
admet-2961	155	5	identified	identify	VERB
admet-2961	155	6	as	as	ADP
admet-2961	155	7	a	a	DET
admet-2961	155	8	metabolite	metabolite	NOUN
admet-2961	155	9	resulting	result	VERB
admet-2961	155	10	from	from	ADP
admet-2961	155	11	o	o	NOUN
admet-2961	155	12	-	-	NOUN
admet-2961	155	13	demethylation	demethylation	NOUN
admet-2961	155	14	and	and	CCONJ
admet-2961	155	15	n	n	CCONJ
admet-2961	155	16	-	-	PUNCT
admet-2961	155	17	dealkylation	dealkylation	NOUN
admet-2961	155	18	.	.	PUNCT
admet-2961	156	1	m21	m21	PROPN
admet-2961	156	2	presented	present	VERB
admet-2961	156	3	a	a	DET
admet-2961	156	4	protonated	protonate	VERB
admet-2961	156	5	molecular	molecular	ADJ
admet-2961	156	6	ion	ion	NOUN
admet-2961	156	7	at	at	ADP
admet-2961	156	8	m	m	PROPN
admet-2961	156	9	/	/	SYM
admet-2961	156	10	z	z	PROPN
admet-2961	156	11	258.1340	258.1340	NUM
admet-2961	156	12	,	,	PUNCT
admet-2961	156	13	with	with	ADP
admet-2961	156	14	a	a	DET
admet-2961	156	15	characteristic	characteristic	ADJ
admet-2961	156	16	ion	ion	NOUN
admet-2961	156	17	at	at	ADP
admet-2961	156	18	m	m	PROPN
admet-2961	156	19	/	/	SYM
admet-2961	156	20	z	z	PROPN
admet-2961	156	21	209.0814	209.0814	NUM
admet-2961	156	22	,	,	PUNCT
admet-2961	156	23	indicating	indicate	VERB
admet-2961	156	24	that	that	SCONJ
admet-2961	156	25	m21	m21	PROPN
admet-2961	156	26	was	be	AUX
admet-2961	156	27	a	a	DET
admet-2961	156	28	di	di	NOUN
admet-2961	156	29	-	-	PUNCT
admet-2961	156	30	oxygenation	oxygenation	NOUN
admet-2961	156	31	metabolite	metabolite	NOUN
admet-2961	156	32	of	of	ADP
admet-2961	156	33	m18	m18	PROPN
admet-2961	156	34	.	.	PUNCT
admet-2961	157	1	glucuronide	glucuronide	ADP
admet-2961	157	2	conjugates	conjugate	NOUN
admet-2961	157	3	m6	m6	PROPN
admet-2961	157	4	showed	show	VERB
admet-2961	157	5	a	a	DET
admet-2961	157	6	protonated	protonate	VERB
admet-2961	157	7	molecular	molecular	ADJ
admet-2961	157	8	ion	ion	NOUN
admet-2961	157	9	at	at	ADP
admet-2961	157	10	m	m	PROPN
admet-2961	157	11	/	/	SYM
admet-2961	157	12	z	z	PROPN
admet-2961	157	13	444.1878	444.1878	NUM
admet-2961	157	14	,	,	PUNCT
admet-2961	157	15	with	with	ADP
admet-2961	157	16	characteristic	characteristic	ADJ
admet-2961	157	17	ions	ion	NOUN
admet-2961	157	18	at	at	ADP
admet-2961	157	19	m	m	PROPN
admet-2961	157	20	/	/	SYM
admet-2961	157	21	z	z	NOUN
admet-2961	157	22	116.1073	116.1073	NUM
admet-2961	157	23	,	,	PUNCT
admet-2961	157	24	226.1074	226.1074	NUM
admet-2961	157	25	,	,	PUNCT
admet-2961	157	26	and	and	CCONJ
admet-2961	157	27	268.1547	268.1547	NUM
admet-2961	157	28	,	,	PUNCT
admet-2961	157	29	indicating	indicate	VERB
admet-2961	157	30	that	that	SCONJ
admet-2961	157	31	m6	m6	PROPN
admet-2961	157	32	was	be	AUX
admet-2961	157	33	a	a	DET
admet-2961	157	34	metabolite	metabolite	NOUN
admet-2961	157	35	of	of	ADP
admet-2961	157	36	o	o	NOUN
admet-2961	157	37	-	-	NOUN
admet-2961	157	38	demethylation	demethylation	NOUN
admet-2961	157	39	,	,	PUNCT
admet-2961	157	40	mono	mono	NOUN
admet-2961	157	41	-	-	PUNCT
admet-2961	157	42	oxygenation	oxygenation	NOUN
admet-2961	157	43	,	,	PUNCT
admet-2961	157	44	dehydrogenation	dehydrogenation	NOUN
admet-2961	157	45	and	and	CCONJ
admet-2961	157	46	glucuronidation	glucuronidation	NOUN
admet-2961	157	47	.	.	PUNCT
admet-2961	158	1	m11	m11	NOUN
admet-2961	158	2	and	and	CCONJ
admet-2961	158	3	m12	m12	PROPN
admet-2961	158	4	exhibited	exhibit	VERB
admet-2961	158	5	the	the	DET
admet-2961	158	6	same	same	ADJ
admet-2961	158	7	protonated	protonate	VERB
admet-2961	158	8	molecular	molecular	ADJ
admet-2961	158	9	ion	ion	NOUN
admet-2961	158	10	at	at	ADP
admet-2961	158	11	m	m	PROPN
admet-2961	158	12	/	/	SYM
admet-2961	158	13	z	z	PROPN
admet-2961	158	14	430.208	430.208	NUM
admet-2961	158	15	,	,	PUNCT
admet-2961	158	16	along	along	ADP
admet-2961	158	17	with	with	ADP
admet-2961	158	18	a	a	DET
admet-2961	158	19	common	common	ADJ
admet-2961	158	20	characteristic	characteristic	ADJ
admet-2961	158	21	ion	ion	NOUN
admet-2961	158	22	at	at	ADP
admet-2961	158	23	m	m	PROPN
admet-2961	158	24	/	/	SYM
admet-2961	158	25	z	z	PROPN
admet-2961	158	26	254.176	254.176	NUM
admet-2961	158	27	,	,	PUNCT
admet-2961	158	28	which	which	PRON
admet-2961	158	29	showed	show	VERB
admet-2961	158	30	a	a	DET
admet-2961	158	31	significant	significant	ADJ
admet-2961	158	32	transition	transition	NOUN
admet-2961	158	33	of	of	ADP
admet-2961	158	34	glucuronidation	glucuronidation	NOUN
admet-2961	158	35	loss	loss	NOUN
admet-2961	158	36	;	;	PUNCT
admet-2961	158	37	thus	thus	ADV
admet-2961	158	38	,	,	PUNCT
admet-2961	158	39	they	they	PRON
admet-2961	158	40	were	be	AUX
admet-2961	158	41	identified	identify	VERB
admet-2961	158	42	as	as	ADP
admet-2961	158	43	glucuronidation	glucuronidation	NOUN
admet-2961	158	44	metabolites	metabolite	NOUN
admet-2961	158	45	derived	derive	VERB
admet-2961	158	46	from	from	ADP
admet-2961	158	47	m13	m13	PROPN
admet-2961	158	48	.	.	PUNCT
admet-2961	159	1	m15	m15	PROPN
admet-2961	159	2	displayed	display	VERB
admet-2961	159	3	a	a	DET
admet-2961	159	4	protonated	protonate	VERB
admet-2961	159	5	molecular	molecular	ADJ
admet-2961	159	6	ion	ion	NOUN
admet-2961	159	7	at	at	ADP
admet-2961	159	8	m	m	PROPN
admet-2961	159	9	/	/	SYM
admet-2961	159	10	z	z	PROPN
admet-2961	159	11	444.1875	444.1875	NUM
admet-2961	159	12	,	,	PUNCT
admet-2961	159	13	with	with	ADP
admet-2961	159	14	characteristic	characteristic	ADJ
admet-2961	159	15	ions	ion	NOUN
admet-2961	159	16	at	at	ADP
admet-2961	159	17	m	m	PROPN
admet-2961	159	18	/	/	SYM
admet-2961	159	19	z	z	PROPN
admet-2961	159	20	191.0709	191.0709	NUM
admet-2961	159	21	and	and	CCONJ
admet-2961	159	22	268.1550	268.1550	NUM
admet-2961	159	23	.	.	PUNCT
admet-2961	160	1	no	no	DET
admet-2961	160	2	modifications	modification	NOUN
admet-2961	160	3	were	be	AUX
admet-2961	160	4	observed	observe	VERB
admet-2961	160	5	on	on	ADP
admet-2961	160	6	the	the	DET
admet-2961	160	7	m	m	PROPN
admet-2961	160	8	/	/	SYM
admet-2961	160	9	z	z	PROPN
admet-2961	160	10	191.1075	191.1075	NUM
admet-2961	160	11	moiety	moiety	NOUN
admet-2961	160	12	,	,	PUNCT
admet-2961	160	13	and	and	CCONJ
admet-2961	160	14	a	a	DET
admet-2961	160	15	glucuronide	glucuronide	ADJ
admet-2961	160	16	loss	loss	NOUN
admet-2961	160	17	(	(	PUNCT
admet-2961	160	18	-176	-176	PROPN
admet-2961	160	19	amu	amu	PROPN
admet-2961	160	20	)	)	PUNCT
admet-2961	160	21	was	be	AUX
admet-2961	160	22	detected	detect	VERB
admet-2961	160	23	from	from	ADP
admet-2961	160	24	m	m	PROPN
admet-2961	160	25	/	/	SYM
admet-2961	160	26	z	z	PROPN
admet-2961	160	27	444.1875	444.1875	NUM
admet-2961	160	28	to	to	ADP
admet-2961	160	29	268.1550	268.1550	NUM
admet-2961	160	30	.	.	PUNCT
admet-2961	161	1	consequently	consequently	ADV
admet-2961	161	2	,	,	PUNCT
admet-2961	161	3	m15	m15	PROPN
admet-2961	161	4	was	be	AUX
admet-2961	161	5	characterized	characterize	VERB
admet-2961	161	6	as	as	ADP
admet-2961	161	7	a	a	DET
admet-2961	161	8	metabolite	metabolite	NOUN
admet-2961	161	9	of	of	ADP
admet-2961	161	10	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	161	11	j.	j.	PROPN
admet-2961	161	12	pu	pu	PROPN
admet-2961	161	13	et	et	PROPN
admet-2961	161	14	al	al	PROPN
admet-2961	161	15	.	.	PROPN
admet-2961	161	16	admet	admet	PROPN
admet-2961	161	17	&	&	CCONJ
admet-2961	161	18	dmpk	dmpk	PROPN
admet-2961	161	19	13(5	13(5	NUM
admet-2961	161	20	)	)	PUNCT
admet-2961	161	21	(	(	PUNCT
admet-2961	161	22	2025	2025	NUM
admet-2961	161	23	)	)	PUNCT
admet-2961	161	24	2961	2961	NUM
admet-2961	161	25	10	10	NUM
admet-2961	161	26	acetylation	acetylation	NOUN
admet-2961	161	27	and	and	CCONJ
admet-2961	161	28	glucuronidation	glucuronidation	NOUN
admet-2961	161	29	derived	derive	VERB
admet-2961	161	30	from	from	ADP
admet-2961	161	31	m18	m18	PROPN
admet-2961	161	32	.	.	PUNCT
admet-2961	162	1	m19	m19	PROPN
admet-2961	162	2	displayed	display	VERB
admet-2961	162	3	a	a	DET
admet-2961	162	4	protonated	protonate	VERB
admet-2961	162	5	molecular	molecular	ADJ
admet-2961	162	6	ion	ion	NOUN
admet-2961	162	7	at	at	ADP
admet-2961	162	8	m	m	PROPN
admet-2961	162	9	/	/	SYM
admet-2961	162	10	z	z	PROPN
admet-2961	162	11	444.224	444.224	NUM
admet-2961	162	12	,	,	PUNCT
admet-2961	162	13	with	with	ADP
admet-2961	162	14	characteristic	characteristic	ADJ
admet-2961	162	15	ions	ion	NOUN
admet-2961	162	16	at	at	ADP
admet-2961	162	17	m	m	PROPN
admet-2961	162	18	/	/	SYM
admet-2961	162	19	z	z	PROPN
admet-2961	162	20	116.1073	116.1073	NUM
admet-2961	162	21	and	and	CCONJ
admet-2961	162	22	268.1914	268.1914	NUM
admet-2961	162	23	.	.	PUNCT
admet-2961	163	1	a	a	DET
admet-2961	163	2	notable	notable	ADJ
admet-2961	163	3	glucuronide	glucuronide	ADJ
admet-2961	163	4	loss	loss	NOUN
admet-2961	163	5	(	(	PUNCT
admet-2961	163	6	-176	-176	PROPN
admet-2961	163	7	amu	amu	PROPN
admet-2961	163	8	)	)	PUNCT
admet-2961	163	9	was	be	AUX
admet-2961	163	10	detected	detect	VERB
admet-2961	163	11	,	,	PUNCT
admet-2961	163	12	transitioning	transition	VERB
admet-2961	163	13	from	from	ADP
admet-2961	163	14	m	m	PROPN
admet-2961	163	15	/	/	SYM
admet-2961	163	16	z	z	PROPN
admet-2961	163	17	444.224	444.224	NUM
admet-2961	163	18	to	to	ADP
admet-2961	163	19	268.191	268.191	NUM
admet-2961	163	20	,	,	PUNCT
admet-2961	163	21	leading	lead	VERB
admet-2961	163	22	to	to	ADP
admet-2961	163	23	its	its	PRON
admet-2961	163	24	identification	identification	NOUN
admet-2961	163	25	as	as	ADP
admet-2961	163	26	a	a	DET
admet-2961	163	27	glucuronidation	glucuronidation	NOUN
admet-2961	163	28	metabolite	metabolite	NOUN
admet-2961	163	29	.	.	PUNCT
admet-2961	164	1	m20	m20	PROPN
admet-2961	164	2	and	and	CCONJ
admet-2961	164	3	m22	m22	PROPN
admet-2961	164	4	displayed	display	VERB
admet-2961	164	5	the	the	DET
admet-2961	164	6	same	same	ADJ
admet-2961	164	7	protonated	protonate	VERB
admet-2961	164	8	molecular	molecular	ADJ
admet-2961	164	9	ion	ion	NOUN
admet-2961	164	10	at	at	ADP
admet-2961	164	11	m	m	PROPN
admet-2961	164	12	/	/	SYM
admet-2961	164	13	z	z	NOUN
admet-2961	164	14	460.219	460.219	NUM
admet-2961	164	15	,	,	PUNCT
admet-2961	164	16	and	and	CCONJ
admet-2961	164	17	they	they	PRON
admet-2961	164	18	exhibited	exhibit	VERB
admet-2961	164	19	identical	identical	ADJ
admet-2961	164	20	characteristic	characteristic	ADJ
admet-2961	164	21	ions	ion	NOUN
admet-2961	164	22	at	at	ADP
admet-2961	164	23	m	m	PROPN
admet-2961	164	24	/	/	SYM
admet-2961	164	25	z	z	PROPN
admet-2961	164	26	114.092	114.092	NUM
admet-2961	164	27	and	and	CCONJ
admet-2961	164	28	284.186	284.186	NUM
admet-2961	164	29	,	,	PUNCT
admet-2961	164	30	indicating	indicate	VERB
admet-2961	164	31	that	that	SCONJ
admet-2961	164	32	they	they	PRON
admet-2961	164	33	were	be	AUX
admet-2961	164	34	metabolites	metabolite	NOUN
admet-2961	164	35	resulting	result	VERB
admet-2961	164	36	from	from	ADP
admet-2961	164	37	monooxygenation	monooxygenation	NOUN
admet-2961	164	38	and	and	CCONJ
admet-2961	164	39	glucuronidation	glucuronidation	NOUN
admet-2961	164	40	.	.	PUNCT
admet-2961	165	1	glutathione	glutathione	NOUN
admet-2961	165	2	conjugates	conjugate	NOUN
admet-2961	165	3	m7	m7	PROPN
admet-2961	165	4	and	and	CCONJ
admet-2961	165	5	m14	m14	PROPN
admet-2961	165	6	exhibited	exhibit	VERB
admet-2961	165	7	a	a	DET
admet-2961	165	8	common	common	ADJ
admet-2961	165	9	protonated	protonate	VERB
admet-2961	165	10	molecular	molecular	ADJ
admet-2961	165	11	ion	ion	NOUN
admet-2961	165	12	at	at	ADP
admet-2961	165	13	m	m	PROPN
admet-2961	165	14	/	/	SYM
admet-2961	165	15	z	z	PROPN
admet-2961	165	16	295.1287	295.1287	NUM
admet-2961	165	17	(	(	PUNCT
admet-2961	165	18	z	z	NOUN
admet-2961	165	19	=	=	SYM
admet-2961	165	20	2	2	NUM
admet-2961	165	21	)	)	PUNCT
admet-2961	165	22	.	.	PUNCT
admet-2961	166	1	the	the	DET
admet-2961	166	2	characteristic	characteristic	ADJ
admet-2961	166	3	ions	ion	NOUN
admet-2961	166	4	observed	observe	VERB
admet-2961	166	5	were	be	AUX
admet-2961	166	6	m	m	PROPN
admet-2961	166	7	/	/	SYM
admet-2961	166	8	z	z	PROPN
admet-2961	166	9	130.0498	130.0498	NUM
admet-2961	166	10	,	,	PUNCT
admet-2961	166	11	179.0483	179.0483	NUM
admet-2961	166	12	,	,	PUNCT
admet-2961	166	13	308.0923	308.0923	NUM
admet-2961	166	14	and	and	CCONJ
admet-2961	166	15	282.1696	282.1696	NUM
admet-2961	166	16	.	.	PUNCT
admet-2961	167	1	considering	consider	VERB
admet-2961	167	2	these	these	DET
admet-2961	167	3	ions	ion	NOUN
admet-2961	167	4	at	at	ADP
admet-2961	167	5	m	m	PROPN
admet-2961	167	6	/	/	SYM
admet-2961	167	7	z	z	PROPN
admet-2961	167	8	130.0498	130.0498	NUM
admet-2961	167	9	,	,	PUNCT
admet-2961	167	10	179.0483	179.0483	NUM
admet-2961	167	11	and	and	CCONJ
admet-2961	167	12	308.0923	308.0923	NUM
admet-2961	167	13	were	be	AUX
admet-2961	167	14	characteristic	characteristic	ADJ
admet-2961	167	15	fragments	fragment	NOUN
admet-2961	167	16	of	of	ADP
admet-2961	167	17	glutathione	glutathione	NOUN
admet-2961	167	18	conjugates	conjugate	NOUN
admet-2961	167	19	.	.	PUNCT
admet-2961	168	1	moreover	moreover	ADV
admet-2961	168	2	,	,	PUNCT
admet-2961	168	3	mass	mass	NOUN
admet-2961	168	4	spectrometric	spectrometric	ADJ
admet-2961	168	5	analysis	analysis	NOUN
admet-2961	168	6	of	of	ADP
admet-2961	168	7	the	the	DET
admet-2961	168	8	concentrated	concentrate	VERB
admet-2961	168	9	m7	m7	ADJ
admet-2961	168	10	metabolite	metabolite	NOUN
admet-2961	168	11	showed	show	VERB
admet-2961	168	12	enhanced	enhanced	ADJ
admet-2961	168	13	glutathione	glutathione	NOUN
admet-2961	168	14	-	-	PUNCT
admet-2961	168	15	associated	associate	VERB
admet-2961	168	16	fragment	fragment	NOUN
admet-2961	168	17	peaks	peak	NOUN
admet-2961	168	18	(	(	PUNCT
admet-2961	168	19	figure	figure	NOUN
admet-2961	168	20	6	6	NUM
admet-2961	168	21	)	)	PUNCT
admet-2961	168	22	,	,	PUNCT
admet-2961	168	23	providing	provide	VERB
admet-2961	168	24	evidence	evidence	NOUN
admet-2961	168	25	for	for	ADP
admet-2961	168	26	potential	potential	ADJ
admet-2961	168	27	glutathione	glutathione	NOUN
admet-2961	168	28	adduct	adduct	NOUN
admet-2961	168	29	formation	formation	NOUN
admet-2961	168	30	.	.	PUNCT
admet-2961	169	1	therefore	therefore	ADV
admet-2961	169	2	,	,	PUNCT
admet-2961	169	3	m7	m7	PROPN
admet-2961	169	4	and	and	CCONJ
admet-2961	169	5	m14	m14	PROPN
admet-2961	169	6	were	be	AUX
admet-2961	169	7	metabolites	metabolite	NOUN
admet-2961	169	8	resulting	result	VERB
admet-2961	169	9	from	from	ADP
admet-2961	169	10	mono	mono	NOUN
admet-2961	169	11	-	-	PUNCT
admet-2961	169	12	oxygenation	oxygenation	NOUN
admet-2961	169	13	and	and	CCONJ
admet-2961	169	14	glutathionylation	glutathionylation	NOUN
admet-2961	169	15	(	(	PUNCT
admet-2961	169	16	displacement	displacement	NOUN
admet-2961	169	17	)	)	PUNCT
admet-2961	169	18	.	.	PUNCT
admet-2961	170	1	despite	despite	SCONJ
admet-2961	170	2	its	its	PRON
admet-2961	170	3	classification	classification	NOUN
admet-2961	170	4	as	as	ADP
admet-2961	170	5	a	a	DET
admet-2961	170	6	low	low	ADJ
admet-2961	170	7	clearance	clearance	NOUN
admet-2961	170	8	drug	drug	NOUN
admet-2961	170	9	,	,	PUNCT
admet-2961	170	10	the	the	DET
admet-2961	170	11	comprehensive	comprehensive	ADJ
admet-2961	170	12	metabolic	metabolic	NOUN
admet-2961	170	13	fate	fate	NOUN
admet-2961	170	14	of	of	ADP
admet-2961	170	15	metoprolol	metoprolol	PROPN
admet-2961	170	16	remains	remain	VERB
admet-2961	170	17	incompletely	incompletely	ADV
admet-2961	170	18	characterized	characterize	VERB
admet-2961	170	19	in	in	ADP
admet-2961	170	20	current	current	ADJ
admet-2961	170	21	literature	literature	NOUN
admet-2961	170	22	.	.	PUNCT
admet-2961	171	1	notably	notably	ADV
admet-2961	171	2	,	,	PUNCT
admet-2961	171	3	our	our	PRON
admet-2961	171	4	study	study	NOUN
admet-2961	171	5	has	have	AUX
admet-2961	171	6	identified	identify	VERB
admet-2961	171	7	up	up	ADP
admet-2961	171	8	to	to	PART
admet-2961	171	9	22	22	NUM
admet-2961	171	10	metabolites	metabolite	NOUN
admet-2961	171	11	in	in	ADP
admet-2961	171	12	plateable	plateable	ADJ
admet-2961	171	13	hepatocytes	hepatocyte	NOUN
admet-2961	171	14	,	,	PUNCT
admet-2961	171	15	as	as	SCONJ
admet-2961	171	16	shown	show	VERB
admet-2961	171	17	in	in	ADP
admet-2961	171	18	table	table	NOUN
admet-2961	171	19	1	1	NUM
admet-2961	171	20	,	,	PUNCT
admet-2961	171	21	significantly	significantly	ADV
admet-2961	171	22	expanding	expand	VERB
admet-2961	171	23	upon	upon	SCONJ
admet-2961	171	24	previously	previously	ADV
admet-2961	171	25	identified	identify	VERB
admet-2961	171	26	metabolites	metabolite	NOUN
admet-2961	171	27	[	[	PUNCT
admet-2961	171	28	62	62	NUM
admet-2961	171	29	-	-	SYM
admet-2961	171	30	69,75,76	69,75,76	NUM
admet-2961	171	31	]	]	PUNCT
admet-2961	171	32	.	.	PUNCT
admet-2961	172	1	tao	tao	PROPN
admet-2961	172	2	et	et	PROPN
admet-2961	172	3	al	al	PROPN
admet-2961	173	1	[	[	X
admet-2961	173	2	62	62	NUM
admet-2961	173	3	]	]	PUNCT
admet-2961	173	4	identified	identify	VERB
admet-2961	173	5	two	two	NUM
admet-2961	173	6	metabolites	metabolite	NOUN
admet-2961	173	7	,	,	PUNCT
admet-2961	173	8	α	α	NOUN
admet-2961	173	9	-	-	PUNCT
admet-2961	173	10	hydroxy	hydroxy	VERB
admet-2961	173	11	-	-	PUNCT
admet-2961	173	12	metoprolol	metoprolol	NOUN
admet-2961	173	13	(	(	PUNCT
admet-2961	173	14	m	m	NOUN
admet-2961	173	15	/	/	SYM
admet-2961	173	16	z	z	PROPN
admet-2961	173	17	116.1	116.1	NUM
admet-2961	173	18	,	,	PUNCT
admet-2961	173	19	133.1	133.1	NUM
admet-2961	173	20	,	,	PUNCT
admet-2961	173	21	163.1	163.1	NUM
admet-2961	173	22	and	and	CCONJ
admet-2961	173	23	207.1	207.1	NUM
admet-2961	173	24	)	)	PUNCT
admet-2961	173	25	and	and	CCONJ
admet-2961	173	26	o	o	NOUN
admet-2961	173	27	-	-	NOUN
admet-2961	173	28	desmethyl	desmethyl	NOUN
admet-2961	173	29	-	-	PUNCT
admet-2961	173	30	metoprolol	metoprolol	NOUN
admet-2961	173	31	(	(	PUNCT
admet-2961	173	32	m	m	PROPN
admet-2961	173	33	/	/	SYM
admet-2961	173	34	z	z	PROPN
admet-2961	173	35	98.1	98.1	NUM
admet-2961	173	36	,	,	PUNCT
admet-2961	173	37	116.1	116.1	NUM
admet-2961	173	38	,	,	PUNCT
admet-2961	173	39	and	and	CCONJ
admet-2961	173	40	177.1	177.1	NUM
admet-2961	173	41	)	)	PUNCT
admet-2961	173	42	.	.	PUNCT
admet-2961	174	1	both	both	DET
admet-2961	174	2	metabolites	metabolite	NOUN
admet-2961	174	3	were	be	AUX
admet-2961	174	4	also	also	ADV
admet-2961	174	5	detected	detect	VERB
admet-2961	174	6	in	in	ADP
admet-2961	174	7	plateable	plateable	ADJ
admet-2961	174	8	hepatocytes	hepatocyte	NOUN
admet-2961	174	9	,	,	PUNCT
admet-2961	174	10	with	with	ADP
admet-2961	174	11	more	more	ADV
admet-2961	174	12	abundant	abundant	ADJ
admet-2961	174	13	fragments	fragment	NOUN
admet-2961	174	14	for	for	ADP
admet-2961	174	15	α	α	NOUN
admet-2961	174	16	-	-	PUNCT
admet-2961	174	17	hydroxy	hydroxy	VERB
admet-2961	174	18	-	-	PUNCT
admet-2961	174	19	metoprolol	metoprolol	NOUN
admet-2961	174	20	(	(	PUNCT
admet-2961	174	21	m	m	NOUN
admet-2961	174	22	/	/	SYM
admet-2961	174	23	z	z	PROPN
admet-2961	174	24	56.0500	56.0500	NUM
admet-2961	174	25	,	,	PUNCT
admet-2961	174	26	74.0603	74.0603	NUM
admet-2961	174	27	,	,	PUNCT
admet-2961	174	28	86.0966	86.0966	NUM
admet-2961	174	29	,	,	PUNCT
admet-2961	174	30	98.0968	98.0968	NUM
admet-2961	174	31	,	,	PUNCT
admet-2961	174	32	116.1074	116.1074	NUM
admet-2961	174	33	,	,	PUNCT
admet-2961	174	34	133.0653	133.0653	NUM
admet-2961	174	35	,	,	PUNCT
admet-2961	174	36	163.0758	163.0758	NUM
admet-2961	174	37	,	,	PUNCT
admet-2961	174	38	207.1025	207.1025	NUM
admet-2961	174	39	and	and	CCONJ
admet-2961	174	40	224.1289	224.1289	NUM
admet-2961	174	41	)	)	PUNCT
admet-2961	174	42	and	and	CCONJ
admet-2961	174	43	o	o	NOUN
admet-2961	174	44	-	-	NOUN
admet-2961	174	45	desmethyl	desmethyl	NOUN
admet-2961	174	46	-	-	PUNCT
admet-2961	174	47	metoprolol	metoprolol	NOUN
admet-2961	174	48	(	(	PUNCT
admet-2961	174	49	m	m	NOUN
admet-2961	174	50	/	/	SYM
admet-2961	174	51	z	z	NOUN
admet-2961	174	52	56.0499	56.0499	NUM
admet-2961	174	53	,	,	PUNCT
admet-2961	174	54	72.0810	72.0810	NUM
admet-2961	174	55	,	,	PUNCT
admet-2961	174	56	74.0602	74.0602	NUM
admet-2961	174	57	,	,	PUNCT
admet-2961	174	58	98.0966	98.0966	NUM
admet-2961	174	59	,	,	PUNCT
admet-2961	174	60	116.1072	116.1072	NUM
admet-2961	174	61	,	,	PUNCT
admet-2961	174	62	133.0651	133.0651	NUM
admet-2961	174	63	,	,	PUNCT
admet-2961	174	64	151.0757	151.0757	NUM
admet-2961	174	65	,	,	PUNCT
admet-2961	174	66	159.0808	159.0808	NUM
admet-2961	174	67	,	,	PUNCT
admet-2961	174	68	177.0914	177.0914	NUM
admet-2961	174	69	and	and	CCONJ
admet-2961	174	70	212.1285	212.1285	NUM
admet-2961	174	71	)	)	PUNCT
admet-2961	174	72	.	.	PUNCT
admet-2961	175	1	li	li	PROPN
admet-2961	175	2	et	et	PROPN
admet-2961	175	3	al	al	PROPN
admet-2961	175	4	.	.	PUNCT
admet-2961	176	1	[	[	X
admet-2961	176	2	63	63	NUM
admet-2961	176	3	]	]	PUNCT
admet-2961	176	4	and	and	CCONJ
admet-2961	176	5	bae	bae	PROPN
admet-2961	176	6	et	et	PROPN
admet-2961	176	7	al	al	PROPN
admet-2961	176	8	.	.	PUNCT
admet-2961	177	1	[	[	X
admet-2961	177	2	67	67	NUM
admet-2961	177	3	]	]	PUNCT
admet-2961	177	4	reported	report	VERB
admet-2961	177	5	the	the	DET
admet-2961	177	6	formation	formation	NOUN
admet-2961	177	7	of	of	ADP
admet-2961	177	8	reactive	reactive	ADJ
admet-2961	177	9	glutathione	glutathione	NOUN
admet-2961	177	10	adducts	adduct	NOUN
admet-2961	177	11	through	through	ADP
admet-2961	177	12	the	the	DET
admet-2961	177	13	artificial	artificial	ADJ
admet-2961	177	14	addition	addition	NOUN
admet-2961	177	15	of	of	ADP
admet-2961	177	16	the	the	DET
admet-2961	177	17	xenobiotic	xenobiotic	ADJ
admet-2961	177	18	glutathione	glutathione	NOUN
admet-2961	177	19	cofactor	cofactor	NOUN
admet-2961	177	20	.	.	PUNCT
admet-2961	178	1	consistent	consistent	ADJ
admet-2961	178	2	with	with	ADP
admet-2961	178	3	this	this	PRON
admet-2961	178	4	,	,	PUNCT
admet-2961	178	5	two	two	NUM
admet-2961	178	6	glutathione	glutathione	NOUN
admet-2961	178	7	adducts	adduct	NOUN
admet-2961	178	8	were	be	AUX
admet-2961	178	9	directly	directly	ADV
admet-2961	178	10	captured	capture	VERB
admet-2961	178	11	in	in	ADP
admet-2961	178	12	plateable	plateable	ADJ
admet-2961	178	13	rat	rat	NOUN
admet-2961	178	14	and	and	CCONJ
admet-2961	178	15	human	human	ADJ
admet-2961	178	16	hepatocytes	hepatocyte	NOUN
admet-2961	178	17	,	,	PUNCT
admet-2961	178	18	demonstrating	demonstrate	VERB
admet-2961	178	19	prolonged	prolong	VERB
admet-2961	178	20	metabolic	metabolic	NOUN
admet-2961	178	21	enzyme	enzyme	NOUN
admet-2961	178	22	activity	activity	NOUN
admet-2961	178	23	.	.	PUNCT
admet-2961	179	1	figure	figure	NOUN
admet-2961	179	2	6	6	NUM
admet-2961	179	3	.	.	PUNCT
admet-2961	180	1	collision	collision	NOUN
admet-2961	180	2	-	-	PUNCT
admet-2961	180	3	induced	induce	VERB
admet-2961	180	4	dissociation	dissociation	NOUN
admet-2961	180	5	spectrum	spectrum	NOUN
admet-2961	180	6	(	(	PUNCT
admet-2961	180	7	a	a	NOUN
admet-2961	180	8	)	)	PUNCT
admet-2961	180	9	and	and	CCONJ
admet-2961	180	10	structural	structural	ADJ
admet-2961	180	11	analysis	analysis	NOUN
admet-2961	180	12	(	(	PUNCT
admet-2961	180	13	b	b	NOUN
admet-2961	180	14	)	)	PUNCT
admet-2961	180	15	of	of	ADP
admet-2961	180	16	m7	m7	PROPN
admet-2961	180	17	admet	admet	PROPN
admet-2961	180	18	&	&	CCONJ
admet-2961	180	19	dmpk	dmpk	PROPN
admet-2961	180	20	16(5	16(5	NUM
admet-2961	180	21	)	)	PUNCT
admet-2961	180	22	(	(	PUNCT
admet-2961	180	23	2025	2025	NUM
admet-2961	180	24	)	)	PUNCT
admet-2961	180	25	2961	2961	NUM
admet-2961	180	26	natural	natural	ADJ
admet-2961	180	27	molecules	molecule	NOUN
admet-2961	180	28	for	for	ADP
admet-2961	180	29	emt	emt	PROPN
admet-2961	180	30	treatment	treatment	NOUN
admet-2961	180	31	doi	doi	NOUN
admet-2961	180	32	:	:	PUNCT
admet-2961	180	33	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	ADJ
admet-2961	180	34	11	11	NUM
admet-2961	180	35	aligning	align	VERB
admet-2961	180	36	with	with	ADP
admet-2961	180	37	the	the	DET
admet-2961	180	38	findings	finding	NOUN
admet-2961	180	39	reported	report	VERB
admet-2961	180	40	by	by	ADP
admet-2961	180	41	ma	ma	PROPN
admet-2961	180	42	et	et	PROPN
admet-2961	180	43	al	al	PROPN
admet-2961	180	44	.	.	PUNCT
admet-2961	181	1	[	[	X
admet-2961	181	2	77	77	NUM
admet-2961	181	3	]	]	X
admet-2961	181	4	,	,	PUNCT
admet-2961	181	5	plateable	plateable	ADJ
admet-2961	181	6	hepatocytes	hepatocyte	NOUN
admet-2961	181	7	effectively	effectively	ADV
admet-2961	181	8	captured	capture	VERB
admet-2961	181	9	the	the	DET
admet-2961	181	10	lowclearance	lowclearance	NOUN
admet-2961	181	11	characteristics	characteristic	NOUN
admet-2961	181	12	and	and	CCONJ
admet-2961	181	13	pronounced	pronounce	VERB
admet-2961	181	14	interspecies	interspecie	NOUN
admet-2961	181	15	differences	difference	NOUN
admet-2961	181	16	in	in	ADP
admet-2961	181	17	metoprolol	metoprolol	NOUN
admet-2961	181	18	metabolism	metabolism	NOUN
admet-2961	181	19	after	after	ADP
admet-2961	181	20	prolonged	prolonged	ADJ
admet-2961	181	21	incubation	incubation	NOUN
admet-2961	181	22	.	.	PUNCT
admet-2961	182	1	human	human	ADJ
admet-2961	182	2	plateable	plateable	ADJ
admet-2961	182	3	hepatocytes	hepatocyte	NOUN
admet-2961	182	4	maintained	maintain	VERB
admet-2961	182	5	functional	functional	ADJ
admet-2961	182	6	cytochrome	cytochrome	NOUN
admet-2961	182	7	p450	p450	NUM
admet-2961	182	8	enzymes	enzyme	NOUN
admet-2961	182	9	and	and	CCONJ
admet-2961	182	10	accurately	accurately	ADV
admet-2961	182	11	recapitulated	recapitulate	VERB
admet-2961	182	12	metabolism	metabolism	NOUN
admet-2961	182	13	mediated	mediate	VERB
admet-2961	182	14	by	by	ADP
admet-2961	182	15	human	human	ADJ
admet-2961	182	16	recombinant	recombinant	ADJ
admet-2961	182	17	cyp2d6	cyp2d6	NOUN
admet-2961	182	18	enzymes	enzyme	NOUN
admet-2961	182	19	,	,	PUNCT
admet-2961	182	20	with	with	ADP
admet-2961	182	21	principal	principal	ADJ
admet-2961	182	22	metabolites	metabolite	NOUN
admet-2961	182	23	exhibiting	exhibit	VERB
admet-2961	182	24	comparable	comparable	ADJ
admet-2961	182	25	relative	relative	ADJ
admet-2961	182	26	abundance	abundance	NOUN
admet-2961	182	27	profiles	profile	NOUN
admet-2961	182	28	(	(	PUNCT
admet-2961	182	29	m10	m10	PROPN
admet-2961	182	30	,	,	PUNCT
admet-2961	182	31	m13	m13	NOUN
admet-2961	182	32	,	,	PUNCT
admet-2961	182	33	and	and	CCONJ
admet-2961	182	34	m17	m17	NUM
admet-2961	182	35	)	)	PUNCT
admet-2961	182	36	.	.	PUNCT
admet-2961	183	1	notably	notably	ADV
admet-2961	183	2	,	,	PUNCT
admet-2961	183	3	m10	m10	PROPN
admet-2961	183	4	was	be	AUX
admet-2961	183	5	a	a	DET
admet-2961	183	6	minor	minor	ADJ
admet-2961	183	7	metabolite	metabolite	NOUN
admet-2961	183	8	in	in	ADP
admet-2961	183	9	human	human	ADJ
admet-2961	183	10	plateable	plateable	ADJ
admet-2961	183	11	hepatocytes	hepatocyte	NOUN
admet-2961	183	12	but	but	CCONJ
admet-2961	183	13	constituted	constitute	VERB
admet-2961	183	14	the	the	DET
admet-2961	183	15	major	major	ADJ
admet-2961	183	16	metabolite	metabolite	NOUN
admet-2961	183	17	in	in	ADP
admet-2961	183	18	rat	rat	NOUN
admet-2961	183	19	plateable	plateable	ADJ
admet-2961	183	20	hepatocytes	hepatocyte	NOUN
admet-2961	183	21	.	.	PUNCT
admet-2961	184	1	moreover	moreover	ADV
admet-2961	184	2	,	,	PUNCT
admet-2961	184	3	m10	m10	PROPN
admet-2961	184	4	demonstrated	demonstrate	VERB
admet-2961	184	5	a	a	DET
admet-2961	184	6	tendency	tendency	NOUN
admet-2961	184	7	for	for	ADP
admet-2961	184	8	further	further	ADJ
admet-2961	184	9	metabolism	metabolism	NOUN
admet-2961	184	10	into	into	ADP
admet-2961	184	11	a	a	DET
admet-2961	184	12	glutathione	glutathione	NOUN
admet-2961	184	13	(	(	PUNCT
admet-2961	184	14	gsh	gsh	PROPN
admet-2961	184	15	)	)	PUNCT
admet-2961	184	16	conjugate	conjugate	VERB
admet-2961	184	17	in	in	ADP
admet-2961	184	18	rat	rat	NOUN
admet-2961	184	19	hepatocytes	hepatocyte	NOUN
admet-2961	184	20	,	,	PUNCT
admet-2961	184	21	suggesting	suggest	VERB
admet-2961	184	22	potential	potential	ADJ
admet-2961	184	23	toxicity	toxicity	NOUN
admet-2961	184	24	associated	associate	VERB
admet-2961	184	25	with	with	ADP
admet-2961	184	26	reactive	reactive	ADJ
admet-2961	184	27	metabolite	metabolite	NOUN
admet-2961	184	28	formation	formation	NOUN
admet-2961	184	29	.	.	PUNCT
admet-2961	185	1	the	the	DET
admet-2961	185	2	involvement	involvement	NOUN
admet-2961	185	3	of	of	ADP
admet-2961	185	4	cyp	cyp	ADJ
admet-2961	185	5	-	-	PUNCT
admet-2961	185	6	mediated	mediate	VERB
admet-2961	185	7	bioactivation	bioactivation	NOUN
admet-2961	185	8	in	in	ADP
admet-2961	185	9	this	this	DET
admet-2961	185	10	toxic	toxic	ADJ
admet-2961	185	11	pathway	pathway	NOUN
admet-2961	185	12	was	be	AUX
admet-2961	185	13	further	far	ADV
admet-2961	185	14	supported	support	VERB
admet-2961	185	15	by	by	ADP
admet-2961	185	16	irreversible	irreversible	ADJ
admet-2961	185	17	inhibition	inhibition	NOUN
admet-2961	185	18	using	use	VERB
admet-2961	185	19	1	1	NUM
admet-2961	185	20	-	-	PUNCT
admet-2961	185	21	aminobenzotriazole	aminobenzotriazole	NOUN
admet-2961	185	22	,	,	PUNCT
admet-2961	185	23	a	a	DET
admet-2961	185	24	non	non	ADJ
admet-2961	185	25	-	-	ADJ
admet-2961	185	26	specific	specific	ADJ
admet-2961	185	27	cyp	cyp	ADJ
admet-2961	185	28	inhibitor	inhibitor	NOUN
admet-2961	185	29	,	,	PUNCT
admet-2961	185	30	which	which	PRON
admet-2961	185	31	substantiated	substantiate	VERB
admet-2961	185	32	the	the	DET
admet-2961	185	33	role	role	NOUN
admet-2961	185	34	of	of	ADP
admet-2961	185	35	cyp2d6	cyp2d6	NOUN
admet-2961	185	36	in	in	ADP
admet-2961	185	37	the	the	DET
admet-2961	185	38	observed	observe	VERB
admet-2961	185	39	hepatotoxic	hepatotoxic	NOUN
admet-2961	185	40	effects	effect	NOUN
admet-2961	185	41	.	.	PUNCT
admet-2961	186	1	conclusion	conclusion	NOUN
admet-2961	186	2	in	in	ADP
admet-2961	186	3	this	this	DET
admet-2961	186	4	study	study	NOUN
admet-2961	186	5	,	,	PUNCT
admet-2961	186	6	metoprolol	metoprolol	PROPN
admet-2961	186	7	was	be	AUX
admet-2961	186	8	characterized	characterize	VERB
admet-2961	186	9	as	as	ADP
admet-2961	186	10	a	a	DET
admet-2961	186	11	low	low	ADJ
admet-2961	186	12	-	-	PUNCT
admet-2961	186	13	clearance	clearance	NOUN
admet-2961	186	14	compound	compound	NOUN
admet-2961	186	15	based	base	VERB
admet-2961	186	16	on	on	ADP
admet-2961	186	17	its	its	PRON
admet-2961	186	18	metabolic	metabolic	NOUN
admet-2961	186	19	profile	profile	NOUN
admet-2961	186	20	in	in	ADP
admet-2961	186	21	plateable	plateable	ADJ
admet-2961	186	22	human	human	ADJ
admet-2961	186	23	hepatocytes	hepatocyte	NOUN
admet-2961	186	24	.	.	PUNCT
admet-2961	187	1	the	the	DET
admet-2961	187	2	plateable	plateable	ADJ
admet-2961	187	3	hepatocyte	hepatocyte	NOUN
admet-2961	187	4	system	system	NOUN
admet-2961	187	5	demonstrated	demonstrate	VERB
admet-2961	187	6	extensive	extensive	ADJ
admet-2961	187	7	metabolic	metabolic	NOUN
admet-2961	187	8	capacity	capacity	NOUN
admet-2961	187	9	,	,	PUNCT
admet-2961	187	10	with	with	ADP
admet-2961	187	11	22	22	NUM
admet-2961	187	12	metabolites	metabolite	NOUN
admet-2961	187	13	of	of	ADP
admet-2961	187	14	metoprolol	metoprolol	NOUN
admet-2961	187	15	identified	identify	VERB
admet-2961	187	16	for	for	ADP
admet-2961	187	17	the	the	DET
admet-2961	187	18	first	first	ADJ
admet-2961	187	19	time	time	NOUN
admet-2961	187	20	.	.	PUNCT
admet-2961	188	1	functionally	functionally	ADV
admet-2961	188	2	competent	competent	ADJ
admet-2961	188	3	cytochrome	cytochrome	NOUN
admet-2961	188	4	p450	p450	NUM
admet-2961	188	5	enzymes	enzyme	NOUN
admet-2961	188	6	were	be	AUX
admet-2961	188	7	maintained	maintain	VERB
admet-2961	188	8	in	in	ADP
admet-2961	188	9	human	human	ADJ
admet-2961	188	10	plateable	plateable	ADJ
admet-2961	188	11	hepatocytes	hepatocyte	NOUN
admet-2961	188	12	,	,	PUNCT
admet-2961	188	13	accurately	accurately	ADV
admet-2961	188	14	recapitulating	recapitulate	VERB
admet-2961	188	15	metabolite	metabolite	NOUN
admet-2961	188	16	profiles	profile	NOUN
admet-2961	188	17	generated	generate	VERB
admet-2961	188	18	by	by	ADP
admet-2961	188	19	human	human	ADJ
admet-2961	188	20	recombinant	recombinant	ADJ
admet-2961	188	21	cyp2d6	cyp2d6	NOUN
admet-2961	188	22	enzymes	enzyme	NOUN
admet-2961	188	23	.	.	PUNCT
admet-2961	189	1	the	the	DET
admet-2961	189	2	principal	principal	ADJ
admet-2961	189	3	biotransformation	biotransformation	NOUN
admet-2961	189	4	pathways	pathway	NOUN
admet-2961	189	5	consisted	consist	VERB
admet-2961	189	6	of	of	ADP
admet-2961	189	7	o	o	NOUN
admet-2961	189	8	-	-	NOUN
admet-2961	189	9	demethylation	demethylation	NOUN
admet-2961	189	10	,	,	PUNCT
admet-2961	189	11	mono	mono	NOUN
admet-2961	189	12	-	-	PUNCT
admet-2961	189	13	oxygenation	oxygenation	NOUN
admet-2961	189	14	and	and	CCONJ
admet-2961	189	15	oxidative	oxidative	ADJ
admet-2961	189	16	metabolism	metabolism	NOUN
admet-2961	189	17	.	.	PUNCT
admet-2961	190	1	toxicologically	toxicologically	ADV
admet-2961	190	2	,	,	PUNCT
admet-2961	190	3	m10	m10	PROPN
admet-2961	190	4	was	be	AUX
admet-2961	190	5	found	find	VERB
admet-2961	190	6	to	to	PART
admet-2961	190	7	be	be	AUX
admet-2961	190	8	metabolically	metabolically	ADV
admet-2961	190	9	converted	convert	VERB
admet-2961	190	10	into	into	ADP
admet-2961	190	11	a	a	DET
admet-2961	190	12	glutathione	glutathione	NOUN
admet-2961	190	13	(	(	PUNCT
admet-2961	190	14	gsh	gsh	PROPN
admet-2961	190	15	)	)	PUNCT
admet-2961	190	16	conjugate	conjugate	VERB
admet-2961	190	17	in	in	ADP
admet-2961	190	18	rat	rat	NOUN
admet-2961	190	19	plateable	plateable	ADJ
admet-2961	190	20	hepatocytes	hepatocyte	NOUN
admet-2961	190	21	.	.	PUNCT
admet-2961	191	1	the	the	DET
admet-2961	191	2	cyp	cyp	ADJ
admet-2961	191	3	-	-	PUNCT
admet-2961	191	4	dependent	dependent	ADJ
admet-2961	191	5	nature	nature	NOUN
admet-2961	191	6	of	of	ADP
admet-2961	191	7	this	this	DET
admet-2961	191	8	hepatotoxic	hepatotoxic	ADJ
admet-2961	191	9	effect	effect	NOUN
admet-2961	191	10	was	be	AUX
admet-2961	191	11	confirmed	confirm	VERB
admet-2961	191	12	through	through	ADP
admet-2961	191	13	reversible	reversible	ADJ
admet-2961	191	14	inhibition	inhibition	NOUN
admet-2961	191	15	using	use	VERB
admet-2961	191	16	the	the	DET
admet-2961	191	17	non	non	ADJ
admet-2961	191	18	-	-	ADJ
admet-2961	191	19	specific	specific	ADJ
admet-2961	191	20	cyp	cyp	ADJ
admet-2961	191	21	inhibitor	inhibitor	NOUN
admet-2961	191	22	1	1	NUM
admet-2961	191	23	-	-	PUNCT
admet-2961	191	24	aminobenzotriazole	aminobenzotriazole	NOUN
admet-2961	191	25	.	.	PUNCT
admet-2961	192	1	while	while	SCONJ
admet-2961	192	2	weak	weak	ADJ
admet-2961	192	3	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	192	4	occurred	occur	VERB
admet-2961	192	5	in	in	ADP
admet-2961	192	6	rat	rat	NOUN
admet-2961	192	7	hepatocytes	hepatocyte	NOUN
admet-2961	192	8	at	at	ADP
admet-2961	192	9	a	a	DET
admet-2961	192	10	supratherapeutic	supratherapeutic	ADJ
admet-2961	192	11	concentration	concentration	NOUN
admet-2961	192	12	of	of	ADP
admet-2961	192	13	500	500	NUM
admet-2961	192	14	μm	μm	NOUN
admet-2961	192	15	,	,	PUNCT
admet-2961	192	16	no	no	DET
admet-2961	192	17	significant	significant	ADJ
admet-2961	192	18	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	192	19	was	be	AUX
admet-2961	192	20	observed	observe	VERB
admet-2961	192	21	in	in	ADP
admet-2961	192	22	human	human	ADJ
admet-2961	192	23	hepatocytes	hepatocyte	NOUN
admet-2961	192	24	at	at	ADP
admet-2961	192	25	metoprolol	metoprolol	PROPN
admet-2961	192	26	concentrations	concentration	NOUN
admet-2961	192	27	below	below	ADP
admet-2961	192	28	500	500	NUM
admet-2961	192	29	μm	μm	NOUN
admet-2961	192	30	.	.	PUNCT
admet-2961	193	1	collectively	collectively	ADV
admet-2961	193	2	,	,	PUNCT
admet-2961	193	3	these	these	DET
admet-2961	193	4	findings	finding	NOUN
admet-2961	193	5	validate	validate	VERB
admet-2961	193	6	plateable	plateable	ADJ
admet-2961	193	7	hepatocytes	hepatocyte	NOUN
admet-2961	193	8	as	as	ADP
admet-2961	193	9	a	a	DET
admet-2961	193	10	robust	robust	ADJ
admet-2961	193	11	in	in	ADP
admet-2961	193	12	vitro	vitro	X
admet-2961	193	13	system	system	NOUN
admet-2961	193	14	for	for	ADP
admet-2961	193	15	studying	study	VERB
admet-2961	193	16	the	the	DET
admet-2961	193	17	metabolism	metabolism	NOUN
admet-2961	193	18	of	of	ADP
admet-2961	193	19	low	low	ADJ
admet-2961	193	20	-	-	PUNCT
admet-2961	193	21	clearance	clearance	NOUN
admet-2961	193	22	compounds	compound	NOUN
admet-2961	193	23	,	,	PUNCT
admet-2961	193	24	offering	offer	VERB
admet-2961	193	25	valuable	valuable	ADJ
admet-2961	193	26	insights	insight	NOUN
admet-2961	193	27	for	for	ADP
admet-2961	193	28	preclinical	preclinical	ADJ
admet-2961	193	29	drug	drug	NOUN
admet-2961	193	30	safety	safety	NOUN
admet-2961	193	31	assessment	assessment	NOUN
admet-2961	193	32	.	.	PUNCT
admet-2961	194	1	supplementary	supplementary	ADJ
admet-2961	194	2	material	material	NOUN
admet-2961	194	3	additional	additional	ADJ
admet-2961	194	4	data	datum	NOUN
admet-2961	194	5	are	be	AUX
admet-2961	194	6	available	available	ADJ
admet-2961	194	7	at	at	ADP
admet-2961	194	8	https://pub.iapchem.org/ojs/index.php/admet/article/view/2961	https://pub.iapchem.org/ojs/index.php/admet/article/view/2961	PROPN
admet-2961	194	9	,	,	PUNCT
admet-2961	194	10	or	or	CCONJ
admet-2961	194	11	from	from	ADP
admet-2961	194	12	the	the	DET
admet-2961	194	13	corresponding	corresponding	ADJ
admet-2961	194	14	author	author	NOUN
admet-2961	194	15	on	on	ADP
admet-2961	194	16	request	request	NOUN
admet-2961	194	17	.	.	PUNCT
admet-2961	195	1	human	human	ADJ
admet-2961	195	2	and	and	CCONJ
admet-2961	195	3	animal	animal	NOUN
admet-2961	195	4	rights	right	NOUN
admet-2961	195	5	:	:	PUNCT
admet-2961	195	6	all	all	DET
admet-2961	195	7	hepatocytes	hepatocyte	NOUN
admet-2961	195	8	were	be	AUX
admet-2961	195	9	purchased	purchase	VERB
admet-2961	195	10	from	from	ADP
admet-2961	195	11	commercially	commercially	ADV
admet-2961	195	12	available	available	ADJ
admet-2961	195	13	vendors	vendor	NOUN
admet-2961	195	14	,	,	PUNCT
admet-2961	195	15	there	there	PRON
admet-2961	195	16	were	be	VERB
admet-2961	195	17	no	no	DET
admet-2961	195	18	animal	animal	NOUN
admet-2961	195	19	related	relate	VERB
admet-2961	195	20	experiments	experiment	NOUN
admet-2961	195	21	in	in	ADP
admet-2961	195	22	this	this	DET
admet-2961	195	23	study	study	NOUN
admet-2961	195	24	.	.	PUNCT
admet-2961	196	1	funding	funding	NOUN
admet-2961	196	2	:	:	PUNCT
admet-2961	196	3	none	none	NOUN
admet-2961	196	4	.	.	PUNCT
admet-2961	197	1	acknowledgements	acknowledgement	NOUN
admet-2961	197	2	:	:	PUNCT
admet-2961	197	3	the	the	DET
admet-2961	197	4	author(s	author(s	NOUN
admet-2961	197	5	)	)	PUNCT
admet-2961	197	6	thank	thank	VERB
admet-2961	197	7	the	the	DET
admet-2961	197	8	reviewers	reviewer	NOUN
admet-2961	197	9	’	'	PUNCT
admet-2961	197	10	valuable	valuable	ADJ
admet-2961	197	11	comments	comment	NOUN
admet-2961	197	12	and	and	CCONJ
admet-2961	197	13	suggestions	suggestion	NOUN
admet-2961	197	14	.	.	PUNCT
admet-2961	198	1	conflict	conflict	NOUN
admet-2961	198	2	of	of	ADP
admet-2961	198	3	interest	interest	NOUN
admet-2961	198	4	:	:	PUNCT
admet-2961	198	5	the	the	DET
admet-2961	198	6	authors	author	NOUN
admet-2961	198	7	declare	declare	VERB
admet-2961	198	8	no	no	DET
admet-2961	198	9	conflict	conflict	NOUN
admet-2961	198	10	of	of	ADP
admet-2961	198	11	interest	interest	NOUN
admet-2961	198	12	,	,	PUNCT
admet-2961	198	13	financial	financial	ADJ
admet-2961	198	14	or	or	CCONJ
admet-2961	198	15	otherwise	otherwise	ADV
admet-2961	198	16	.	.	PUNCT
admet-2961	199	1	references	reference	NOUN
admet-2961	199	2	[	[	X
admet-2961	199	3	1	1	NUM
admet-2961	199	4	]	]	X
admet-2961	199	5	n.	n.	PROPN
admet-2961	199	6	blanchard	blanchard	PROPN
admet-2961	199	7	,	,	PUNCT
admet-2961	199	8	n.j	n.j	PROPN
admet-2961	199	9	.	.	PROPN
admet-2961	199	10	hewitt	hewitt	PROPN
admet-2961	199	11	,	,	PUNCT
admet-2961	199	12	p.	p.	PROPN
admet-2961	199	13	silber	silber	PROPN
admet-2961	199	14	,	,	PUNCT
admet-2961	199	15	h.	h.	PROPN
admet-2961	199	16	jones	jones	PROPN
admet-2961	199	17	,	,	PUNCT
admet-2961	199	18	p.	p.	NOUN
admet-2961	199	19	coassolo	coassolo	PROPN
admet-2961	199	20	,	,	PUNCT
admet-2961	199	21	t.	t.	PROPN
admet-2961	199	22	lave	lave	PROPN
admet-2961	199	23	.	.	PUNCT
admet-2961	200	1	prediction	prediction	NOUN
admet-2961	200	2	of	of	ADP
admet-2961	200	3	hepatic	hepatic	ADJ
admet-2961	200	4	clearance	clearance	NOUN
admet-2961	200	5	using	use	VERB
admet-2961	200	6	cryopreserved	cryopreserve	VERB
admet-2961	200	7	human	human	ADJ
admet-2961	200	8	hepatocytes	hepatocyte	NOUN
admet-2961	200	9	:	:	PUNCT
admet-2961	200	10	a	a	DET
admet-2961	200	11	comparison	comparison	NOUN
admet-2961	200	12	of	of	ADP
admet-2961	200	13	serum	serum	NOUN
admet-2961	200	14	and	and	CCONJ
admet-2961	200	15	serum	serum	NOUN
admet-2961	200	16	-	-	PUNCT
admet-2961	200	17	free	free	ADJ
admet-2961	200	18	incubations	incubation	NOUN
admet-2961	200	19	.	.	PUNCT
admet-2961	201	1	journal	journal	NOUN
admet-2961	201	2	of	of	ADP
admet-2961	201	3	pharmacy	pharmacy	NOUN
admet-2961	201	4	and	and	CCONJ
admet-2961	201	5	pharmacology	pharmacology	NOUN
admet-2961	201	6	58	58	NUM
admet-2961	201	7	(	(	PUNCT
admet-2961	201	8	2010	2010	NUM
admet-2961	201	9	)	)	PUNCT
admet-2961	201	10	633	633	NUM
admet-2961	201	11	-	-	SYM
admet-2961	201	12	641	641	NUM
admet-2961	201	13	.	.	PUNCT
admet-2961	202	1	http://doi.org/10.1211/jpp.58.5.0008	http://doi.org/10.1211/jpp.58.5.0008	NOUN
admet-2961	203	1	[	[	X
admet-2961	203	2	2	2	NUM
admet-2961	203	3	]	]	PUNCT
admet-2961	203	4	z.	z.	PROPN
admet-2961	203	5	zhou	zhou	PROPN
admet-2961	203	6	,	,	PUNCT
admet-2961	203	7	m.j	m.j	PROPN
admet-2961	203	8	.	.	PROPN
admet-2961	203	9	xu	xu	PROPN
admet-2961	203	10	,	,	PUNCT
admet-2961	203	11	b.	b.	PROPN
admet-2961	203	12	gao	gao	PROPN
admet-2961	203	13	.	.	PUNCT
admet-2961	203	14	hepatocytes	hepatocytes	PROPN
admet-2961	203	15	:	:	PUNCT
admet-2961	203	16	a	a	DET
admet-2961	203	17	key	key	ADJ
admet-2961	203	18	cell	cell	NOUN
admet-2961	203	19	type	type	NOUN
admet-2961	203	20	for	for	ADP
admet-2961	203	21	innate	innate	ADJ
admet-2961	203	22	immunity	immunity	NOUN
admet-2961	203	23	.	.	PUNCT
admet-2961	204	1	cellular	cellular	ADJ
admet-2961	204	2	and	and	CCONJ
admet-2961	204	3	molecular	molecular	ADJ
admet-2961	204	4	immunology	immunology	NOUN
admet-2961	204	5	13	13	NUM
admet-2961	204	6	(	(	PUNCT
admet-2961	204	7	2016	2016	NUM
admet-2961	204	8	)	)	PUNCT
admet-2961	204	9	301	301	NUM
admet-2961	204	10	-	-	SYM
admet-2961	204	11	315	315	NUM
admet-2961	204	12	.	.	PUNCT
admet-2961	205	1	http://doi.org/10.1038/cmi.2015.97	http://doi.org/10.1038/cmi.2015.97	NOUN
admet-2961	206	1	[	[	X
admet-2961	206	2	3	3	X
admet-2961	206	3	]	]	PUNCT
admet-2961	206	4	d.	d.	PROPN
admet-2961	206	5	dalvie	dalvie	PROPN
admet-2961	206	6	,	,	PUNCT
admet-2961	206	7	r.	r.	PROPN
admet-2961	206	8	scott	scott	PROPN
admet-2961	206	9	obach	obach	PROPN
admet-2961	206	10	,	,	PUNCT
admet-2961	206	11	p.	p.	PROPN
admet-2961	206	12	kang	kang	PROPN
admet-2961	206	13	,	,	PUNCT
admet-2961	206	14	c.	c.	PROPN
admet-2961	206	15	prakash	prakash	PROPN
admet-2961	206	16	,	,	PUNCT
admet-2961	206	17	c.m	c.m	PROPN
admet-2961	206	18	.	.	PROPN
admet-2961	206	19	loi	loi	PROPN
admet-2961	206	20	,	,	PUNCT
admet-2961	206	21	s.	s.	PROPN
admet-2961	206	22	hurst	hurst	PROPN
admet-2961	206	23	,	,	PUNCT
admet-2961	206	24	a.	a.	PROPN
admet-2961	206	25	nedderman	nedderman	PROPN
admet-2961	206	26	,	,	PUNCT
admet-2961	206	27	l.	l.	PROPN
admet-2961	206	28	goulet	goulet	PROPN
admet-2961	206	29	,	,	PUNCT
admet-2961	206	30	e.	e.	PROPN
admet-2961	206	31	smith	smith	PROPN
admet-2961	206	32	,	,	PUNCT
admet-2961	206	33	h.z	h.z	PROPN
admet-2961	206	34	.	.	PROPN
admet-2961	206	35	bu	bu	PROPN
admet-2961	206	36	,	,	PUNCT
admet-2961	206	37	d.a	d.a	PROPN
admet-2961	206	38	.	.	PROPN
admet-2961	206	39	smith	smith	PROPN
admet-2961	206	40	.	.	PROPN
admet-2961	207	1	assessment	assessment	NOUN
admet-2961	207	2	of	of	ADP
admet-2961	207	3	three	three	NUM
admet-2961	207	4	human	human	NOUN
admet-2961	207	5	in	in	ADP
admet-2961	207	6	vitro	vitro	X
admet-2961	207	7	systems	system	NOUN
admet-2961	207	8	in	in	ADP
admet-2961	207	9	the	the	DET
admet-2961	207	10	generation	generation	NOUN
admet-2961	207	11	of	of	ADP
admet-2961	207	12	major	major	ADJ
admet-2961	207	13	human	human	ADJ
admet-2961	207	14	excretory	excretory	NOUN
admet-2961	207	15	and	and	CCONJ
admet-2961	207	16	circulating	circulate	VERB
admet-2961	207	17	metabolites	metabolite	NOUN
admet-2961	207	18	.	.	PUNCT
admet-2961	208	1	chemical	chemical	ADJ
admet-2961	208	2	research	research	NOUN
admet-2961	208	3	in	in	ADP
admet-2961	208	4	toxicology	toxicology	NOUN
admet-2961	208	5	22	22	NUM
admet-2961	208	6	(	(	PUNCT
admet-2961	208	7	2009	2009	NUM
admet-2961	208	8	)	)	PUNCT
admet-2961	208	9	357	357	NUM
admet-2961	208	10	-	-	SYM
admet-2961	208	11	368	368	NUM
admet-2961	208	12	.	.	PUNCT
admet-2961	209	1	http://doi.org/10.1021/tx8004357	http://doi.org/10.1021/tx8004357	VERB
admet-2961	210	1	[	[	X
admet-2961	210	2	4	4	NUM
admet-2961	210	3	]	]	X
admet-2961	210	4	m.g	m.g	PROPN
admet-2961	210	5	.	.	PROPN
admet-2961	210	6	soars	soars	PROPN
admet-2961	210	7	,	,	PUNCT
admet-2961	210	8	d.f	d.f	PROPN
admet-2961	210	9	.	.	PROPN
admet-2961	210	10	mcginnity	mcginnity	PROPN
admet-2961	210	11	,	,	PUNCT
admet-2961	210	12	k.	k.	PROPN
admet-2961	210	13	grime	grime	PROPN
admet-2961	210	14	,	,	PUNCT
admet-2961	210	15	r.j	r.j	PROPN
admet-2961	210	16	.	.	PROPN
admet-2961	210	17	riley	riley	PROPN
admet-2961	210	18	.	.	PUNCT
admet-2961	211	1	the	the	DET
admet-2961	211	2	pivotal	pivotal	ADJ
admet-2961	211	3	role	role	NOUN
admet-2961	211	4	of	of	ADP
admet-2961	211	5	hepatocytes	hepatocyte	NOUN
admet-2961	211	6	in	in	ADP
admet-2961	211	7	drug	drug	NOUN
admet-2961	211	8	discovery	discovery	NOUN
admet-2961	211	9	.	.	PUNCT
admet-2961	212	1	chemico	chemico	ADJ
admet-2961	212	2	-	-	ADJ
admet-2961	212	3	biological	biological	ADJ
admet-2961	212	4	interactions	interaction	NOUN
admet-2961	212	5	168	168	NUM
admet-2961	212	6	(	(	PUNCT
admet-2961	212	7	2007	2007	NUM
admet-2961	212	8	)	)	PUNCT
admet-2961	212	9	2	2	NUM
admet-2961	212	10	-	-	SYM
admet-2961	212	11	15	15	NUM
admet-2961	212	12	.	.	PUNCT
admet-2961	213	1	http://doi.org/10.1016/j.cbi.2006.11.002	http://doi.org/10.1016/j.cbi.2006.11.002	NOUN
admet-2961	213	2	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	213	3	https://pub.iapchem.org/ojs/index.php/admet/article/view/2961	https://pub.iapchem.org/ojs/index.php/admet/article/view/2961	PROPN
admet-2961	213	4	http://doi.org/10.1211/jpp.58.5.0008	http://doi.org/10.1211/jpp.58.5.0008	PROPN
admet-2961	213	5	http://doi.org/10.1038/cmi.2015.97	http://doi.org/10.1038/cmi.2015.97	NOUN
admet-2961	213	6	http://doi.org/10.1021/tx8004357	http://doi.org/10.1021/tx8004357	VERB
admet-2961	213	7	http://doi.org/10.1016/j.cbi.2006.11.002	http://doi.org/10.1016/j.cbi.2006.11.002	PROPN
admet-2961	213	8	j.	j.	PROPN
admet-2961	213	9	pu	pu	PROPN
admet-2961	213	10	et	et	PROPN
admet-2961	213	11	al	al	PROPN
admet-2961	213	12	.	.	PROPN
admet-2961	213	13	admet	admet	PROPN
admet-2961	213	14	&	&	CCONJ
admet-2961	213	15	dmpk	dmpk	PROPN
admet-2961	213	16	13(5	13(5	NUM
admet-2961	213	17	)	)	PUNCT
admet-2961	213	18	(	(	PUNCT
admet-2961	213	19	2025	2025	NUM
admet-2961	213	20	)	)	PUNCT
admet-2961	213	21	2961	2961	NUM
admet-2961	214	1	12	12	NUM
admet-2961	215	1	[	[	X
admet-2961	215	2	5	5	X
admet-2961	215	3	]	]	X
admet-2961	215	4	k.h	k.h	PROPN
admet-2961	215	5	.	.	PROPN
admet-2961	215	6	grime	grime	NOUN
admet-2961	215	7	,	,	PUNCT
admet-2961	215	8	p.	p.	PROPN
admet-2961	215	9	barton	barton	PROPN
admet-2961	215	10	,	,	PUNCT
admet-2961	215	11	d.f	d.f	PROPN
admet-2961	215	12	.	.	PROPN
admet-2961	215	13	mcginnity	mcginnity	NOUN
admet-2961	215	14	.	.	PUNCT
admet-2961	216	1	application	application	NOUN
admet-2961	216	2	of	of	ADP
admet-2961	216	3	in	in	ADP
admet-2961	216	4	silico	silico	NOUN
admet-2961	216	5	,	,	PUNCT
admet-2961	216	6	in	in	ADP
admet-2961	216	7	vitro	vitro	X
admet-2961	216	8	and	and	CCONJ
admet-2961	216	9	preclinical	preclinical	ADJ
admet-2961	216	10	pharmacokinetic	pharmacokinetic	ADJ
admet-2961	216	11	data	datum	NOUN
admet-2961	216	12	for	for	ADP
admet-2961	216	13	the	the	DET
admet-2961	216	14	effective	effective	ADJ
admet-2961	216	15	and	and	CCONJ
admet-2961	216	16	efficient	efficient	ADJ
admet-2961	216	17	prediction	prediction	NOUN
admet-2961	216	18	of	of	ADP
admet-2961	216	19	human	human	ADJ
admet-2961	216	20	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	216	21	.	.	PUNCT
admet-2961	217	1	molecular	molecular	ADJ
admet-2961	217	2	pharmaceutics	pharmaceutic	NOUN
admet-2961	217	3	10	10	NUM
admet-2961	217	4	(	(	PUNCT
admet-2961	217	5	2013	2013	NUM
admet-2961	217	6	)	)	PUNCT
admet-2961	217	7	1191	1191	NUM
admet-2961	217	8	-	-	SYM
admet-2961	217	9	1206	1206	NUM
admet-2961	217	10	.	.	PUNCT
admet-2961	218	1	http://doi.org/10.1021/mp300476z	http://doi.org/10.1021/mp300476z	VERB
admet-2961	219	1	[	[	X
admet-2961	219	2	6	6	NUM
admet-2961	219	3	]	]	X
admet-2961	219	4	a.k	a.k	PROPN
admet-2961	219	5	.	.	PROPN
admet-2961	219	6	sohlenius	sohlenius	PROPN
admet-2961	219	7	-	-	PUNCT
admet-2961	219	8	sternbeck	sternbeck	PROPN
admet-2961	219	9	,	,	PUNCT
admet-2961	219	10	c.	c.	PROPN
admet-2961	219	11	jones	jones	PROPN
admet-2961	219	12	,	,	PUNCT
admet-2961	219	13	d.	d.	PROPN
admet-2961	219	14	ferguson	ferguson	PROPN
admet-2961	219	15	,	,	PUNCT
admet-2961	219	16	b.j	b.j	PROPN
admet-2961	219	17	.	.	PROPN
admet-2961	219	18	middleton	middleton	PROPN
admet-2961	219	19	,	,	PUNCT
admet-2961	219	20	d.	d.	PROPN
admet-2961	219	21	projean	projean	PROPN
admet-2961	219	22	,	,	PUNCT
admet-2961	219	23	e.	e.	PROPN
admet-2961	219	24	floby	floby	PROPN
admet-2961	219	25	,	,	PUNCT
admet-2961	219	26	j.	j.	PROPN
admet-2961	219	27	bylund	bylund	PROPN
admet-2961	219	28	,	,	PUNCT
admet-2961	219	29	l.	l.	PROPN
admet-2961	219	30	afzelius	afzelius	PROPN
admet-2961	219	31	.	.	PUNCT
admet-2961	220	1	practical	practical	ADJ
admet-2961	220	2	use	use	NOUN
admet-2961	220	3	of	of	ADP
admet-2961	220	4	the	the	DET
admet-2961	220	5	regression	regression	NOUN
admet-2961	220	6	offset	offset	VERB
admet-2961	220	7	approach	approach	NOUN
admet-2961	220	8	for	for	ADP
admet-2961	220	9	the	the	DET
admet-2961	220	10	prediction	prediction	NOUN
admet-2961	220	11	of	of	ADP
admet-2961	220	12	in	in	ADP
admet-2961	220	13	vivo	vivo	ADJ
admet-2961	220	14	intrinsic	intrinsic	ADJ
admet-2961	220	15	clearance	clearance	NOUN
admet-2961	220	16	from	from	ADP
admet-2961	220	17	hepatocytes	hepatocytes	PROPN
admet-2961	220	18	.	.	PUNCT
admet-2961	221	1	xenobiotica	xenobiotica	PROPN
admet-2961	221	2	42	42	NUM
admet-2961	221	3	(	(	PUNCT
admet-2961	221	4	2012	2012	NUM
admet-2961	221	5	)	)	PUNCT
admet-2961	221	6	841	841	NUM
admet-2961	221	7	-	-	SYM
admet-2961	221	8	852	852	NUM
admet-2961	221	9	.	.	PUNCT
admet-2961	222	1	http://doi.org/10.3109/00498254.2012.669080	http://doi.org/10.3109/00498254.2012.669080	NOUN
admet-2961	223	1	[	[	X
admet-2961	223	2	7	7	X
admet-2961	223	3	]	]	X
admet-2961	223	4	p.	p.	NOUN
admet-2961	223	5	chao	chao	PROPN
admet-2961	223	6	,	,	PUNCT
admet-2961	223	7	a.s	a.s	PROPN
admet-2961	223	8	.	.	PROPN
admet-2961	223	9	uss	uss	PROPN
admet-2961	223	10	,	,	PUNCT
admet-2961	223	11	k.	k.	PROPN
admet-2961	223	12	cheng	cheng	PROPN
admet-2961	223	13	.	.	PUNCT
admet-2961	224	1	use	use	NOUN
admet-2961	224	2	of	of	ADP
admet-2961	224	3	intrinsic	intrinsic	ADJ
admet-2961	224	4	clearance	clearance	NOUN
admet-2961	224	5	for	for	ADP
admet-2961	224	6	prediction	prediction	NOUN
admet-2961	224	7	of	of	ADP
admet-2961	224	8	human	human	ADJ
admet-2961	224	9	hepatic	hepatic	ADJ
admet-2961	224	10	clearance	clearance	NOUN
admet-2961	224	11	.	.	PUNCT
admet-2961	225	1	expert	expert	ADJ
admet-2961	225	2	opinion	opinion	NOUN
admet-2961	225	3	on	on	ADP
admet-2961	225	4	drug	drug	NOUN
admet-2961	225	5	metabolism	metabolism	NOUN
admet-2961	225	6	and	and	CCONJ
admet-2961	225	7	toxicology	toxicology	NOUN
admet-2961	225	8	6	6	NUM
admet-2961	225	9	(	(	PUNCT
admet-2961	225	10	2010	2010	NUM
admet-2961	225	11	)	)	PUNCT
admet-2961	225	12	189	189	NUM
admet-2961	225	13	-	-	SYM
admet-2961	225	14	198	198	NUM
admet-2961	225	15	.	.	PUNCT
admet-2961	225	16	http://doi.org/10.1517/17425250903405622	http://doi.org/10.1517/17425250903405622	X
admet-2961	226	1	[	[	X
admet-2961	226	2	8	8	NUM
admet-2961	226	3	]	]	X
admet-2961	226	4	r.s	r.s	PROPN
admet-2961	226	5	.	.	PROPN
admet-2961	226	6	obach	obach	PROPN
admet-2961	226	7	.	.	PUNCT
admet-2961	227	1	predicting	predict	VERB
admet-2961	227	2	clearance	clearance	NOUN
admet-2961	227	3	in	in	ADP
admet-2961	227	4	humans	human	NOUN
admet-2961	227	5	from	from	ADP
admet-2961	227	6	in	in	ADP
admet-2961	227	7	vitro	vitro	X
admet-2961	227	8	data	datum	NOUN
admet-2961	227	9	.	.	PUNCT
admet-2961	228	1	current	current	ADJ
admet-2961	228	2	topics	topic	NOUN
admet-2961	228	3	in	in	ADP
admet-2961	228	4	medicinal	medicinal	ADJ
admet-2961	228	5	chemistry	chemistry	NOUN
admet-2961	228	6	11	11	NUM
admet-2961	228	7	(	(	PUNCT
admet-2961	228	8	2011	2011	NUM
admet-2961	228	9	)	)	PUNCT
admet-2961	228	10	334	334	NUM
admet-2961	228	11	-	-	SYM
admet-2961	228	12	339	339	NUM
admet-2961	228	13	.	.	PUNCT
admet-2961	229	1	http://doi.org/10.2174/156802611794480873	http://doi.org/10.2174/156802611794480873	PROPN
admet-2961	230	1	[	[	X
admet-2961	230	2	9	9	X
admet-2961	230	3	]	]	X
admet-2961	230	4	e.l	e.l	PROPN
admet-2961	230	5	.	.	PROPN
admet-2961	230	6	lecluyse	lecluyse	PROPN
admet-2961	230	7	,	,	PUNCT
admet-2961	230	8	e.	e.	PROPN
admet-2961	230	9	alexandre	alexandre	PROPN
admet-2961	230	10	.	.	PUNCT
admet-2961	231	1	isolation	isolation	NOUN
admet-2961	231	2	and	and	CCONJ
admet-2961	231	3	culture	culture	NOUN
admet-2961	231	4	of	of	ADP
admet-2961	231	5	primary	primary	ADJ
admet-2961	231	6	hepatocytes	hepatocyte	NOUN
admet-2961	231	7	from	from	ADP
admet-2961	231	8	resected	resect	VERB
admet-2961	231	9	human	human	ADJ
admet-2961	231	10	liver	liver	NOUN
admet-2961	231	11	tissue	tissue	NOUN
admet-2961	231	12	.	.	PUNCT
admet-2961	232	1	methods	method	NOUN
admet-2961	232	2	in	in	ADP
admet-2961	232	3	molecular	molecular	ADJ
admet-2961	232	4	biology	biology	NOUN
admet-2961	232	5	(	(	PUNCT
admet-2961	232	6	clifton	clifton	PROPN
admet-2961	232	7	,	,	PUNCT
admet-2961	232	8	n.j	n.j	PROPN
admet-2961	232	9	.	.	PROPN
admet-2961	232	10	)	)	PUNCT
admet-2961	232	11	640	640	NUM
admet-2961	232	12	(	(	PUNCT
admet-2961	232	13	2010	2010	NUM
admet-2961	232	14	)	)	PUNCT
admet-2961	232	15	57	57	NUM
admet-2961	232	16	-	-	SYM
admet-2961	232	17	82	82	NUM
admet-2961	232	18	.	.	PUNCT
admet-2961	233	1	http://doi.org/10.1007/978-160761-688-7_3	http://doi.org/10.1007/978-160761-688-7_3	NUM
admet-2961	234	1	[	[	X
admet-2961	234	2	10	10	NUM
admet-2961	234	3	]	]	X
admet-2961	234	4	h.m	h.m	PROPN
admet-2961	234	5	.	.	PROPN
admet-2961	234	6	jones	jones	PROPN
admet-2961	234	7	,	,	PUNCT
admet-2961	234	8	j.b	j.b	PROPN
admet-2961	234	9	.	.	PROPN
admet-2961	234	10	houston	houston	PROPN
admet-2961	234	11	.	.	PUNCT
admet-2961	235	1	substrate	substrate	NOUN
admet-2961	235	2	depletion	depletion	NOUN
admet-2961	235	3	approach	approach	NOUN
admet-2961	235	4	for	for	ADP
admet-2961	235	5	determining	determine	VERB
admet-2961	235	6	in	in	ADP
admet-2961	235	7	vitro	vitro	X
admet-2961	235	8	metabolic	metabolic	NOUN
admet-2961	235	9	clearance	clearance	NOUN
admet-2961	235	10	:	:	PUNCT
admet-2961	235	11	time	time	NOUN
admet-2961	235	12	dependencies	dependency	NOUN
admet-2961	235	13	in	in	ADP
admet-2961	235	14	hepatocyte	hepatocyte	NOUN
admet-2961	235	15	and	and	CCONJ
admet-2961	235	16	microsomal	microsomal	ADJ
admet-2961	235	17	incubations	incubation	NOUN
admet-2961	235	18	.	.	PUNCT
admet-2961	236	1	drug	drug	NOUN
admet-2961	236	2	metabolism	metabolism	NOUN
admet-2961	236	3	and	and	CCONJ
admet-2961	236	4	disposition	disposition	NOUN
admet-2961	236	5	32	32	NUM
admet-2961	236	6	(	(	PUNCT
admet-2961	236	7	2004	2004	NUM
admet-2961	236	8	)	)	PUNCT
admet-2961	237	1	973	973	NUM
admet-2961	237	2	-	-	SYM
admet-2961	237	3	982	982	NUM
admet-2961	237	4	.	.	PUNCT
admet-2961	237	5	http://doi.org/10.1124/dmd.104.000125	http://doi.org/10.1124/dmd.104.000125	NOUN
admet-2961	238	1	[	[	X
admet-2961	238	2	11	11	NUM
admet-2961	238	3	]	]	X
admet-2961	238	4	a.p	a.p	PROPN
admet-2961	238	5	.	.	PROPN
admet-2961	238	6	li	li	PROPN
admet-2961	238	7	,	,	PUNCT
admet-2961	238	8	c.	c.	PROPN
admet-2961	238	9	lu	lu	PROPN
admet-2961	238	10	,	,	PUNCT
admet-2961	238	11	j.a	j.a	PROPN
admet-2961	238	12	.	.	PROPN
admet-2961	238	13	brent	brent	PROPN
admet-2961	238	14	,	,	PUNCT
admet-2961	238	15	c.	c.	PROPN
admet-2961	238	16	pham	pham	PROPN
admet-2961	238	17	,	,	PUNCT
admet-2961	238	18	a.	a.	PROPN
admet-2961	238	19	fackett	fackett	PROPN
admet-2961	238	20	,	,	PUNCT
admet-2961	238	21	c.e	c.e	PROPN
admet-2961	238	22	.	.	PROPN
admet-2961	238	23	ruegg	ruegg	NOUN
admet-2961	238	24	,	,	PUNCT
admet-2961	238	25	p.m.	p.m.	NOUN
admet-2961	238	26	silber	silber	PROPN
admet-2961	238	27	.	.	PUNCT
admet-2961	239	1	cryopreserved	cryopreserve	VERB
admet-2961	239	2	human	human	ADJ
admet-2961	239	3	hepatocytes	hepatocyte	NOUN
admet-2961	239	4	:	:	PUNCT
admet-2961	239	5	characterization	characterization	NOUN
admet-2961	239	6	of	of	ADP
admet-2961	239	7	drug	drug	NOUN
admet-2961	239	8	-	-	PUNCT
admet-2961	239	9	metabolizing	metabolize	VERB
admet-2961	239	10	activities	activity	NOUN
admet-2961	239	11	and	and	CCONJ
admet-2961	239	12	applications	application	NOUN
admet-2961	239	13	in	in	ADP
admet-2961	239	14	higher	high	ADJ
admet-2961	239	15	throughput	throughput	NOUN
admet-2961	239	16	screening	screen	VERB
admet-2961	239	17	assays	assay	NOUN
admet-2961	239	18	for	for	ADP
admet-2961	239	19	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	239	20	,	,	PUNCT
admet-2961	239	21	metabolic	metabolic	NOUN
admet-2961	239	22	stability	stability	NOUN
admet-2961	239	23	,	,	PUNCT
admet-2961	239	24	and	and	CCONJ
admet-2961	239	25	drug	drug	NOUN
admet-2961	239	26	-	-	PUNCT
admet-2961	239	27	drug	drug	NOUN
admet-2961	239	28	interaction	interaction	NOUN
admet-2961	239	29	potential	potential	NOUN
admet-2961	239	30	.	.	PUNCT
admet-2961	240	1	chemicobiological	chemicobiological	ADJ
admet-2961	240	2	interactions	interaction	NOUN
admet-2961	240	3	121	121	NUM
admet-2961	240	4	(	(	PUNCT
admet-2961	240	5	1999	1999	NUM
admet-2961	240	6	)	)	PUNCT
admet-2961	240	7	17	17	NUM
admet-2961	240	8	-	-	SYM
admet-2961	240	9	35	35	NUM
admet-2961	240	10	.	.	PUNCT
admet-2961	241	1	http://doi.org/10.1016/s0009-2797(99)00088-5	http://doi.org/10.1016/s0009-2797(99)00088-5	PROPN
admet-2961	242	1	[	[	X
admet-2961	242	2	12	12	NUM
admet-2961	242	3	]	]	PUNCT
admet-2961	242	4	r.	r.	PROPN
admet-2961	242	5	murgasova	murgasova	PROPN
admet-2961	242	6	.	.	PUNCT
admet-2961	243	1	further	further	ADJ
admet-2961	243	2	assessment	assessment	NOUN
admet-2961	243	3	of	of	ADP
admet-2961	243	4	the	the	DET
admet-2961	243	5	relay	relay	NOUN
admet-2961	243	6	hepatocyte	hepatocyte	NOUN
admet-2961	243	7	assay	assay	VERB
admet-2961	243	8	for	for	ADP
admet-2961	243	9	determination	determination	NOUN
admet-2961	243	10	of	of	ADP
admet-2961	243	11	intrinsic	intrinsic	ADJ
admet-2961	243	12	clearance	clearance	NOUN
admet-2961	243	13	of	of	ADP
admet-2961	243	14	slowly	slowly	ADV
admet-2961	243	15	metabolised	metabolise	VERB
admet-2961	243	16	compounds	compound	NOUN
admet-2961	243	17	using	use	VERB
admet-2961	243	18	radioactivity	radioactivity	NOUN
admet-2961	243	19	monitoring	monitoring	NOUN
admet-2961	243	20	and	and	CCONJ
admet-2961	243	21	lc	lc	NOUN
admet-2961	243	22	-	-	PUNCT
admet-2961	243	23	ms	ms	NOUN
admet-2961	243	24	methods	method	NOUN
admet-2961	243	25	.	.	PUNCT
admet-2961	244	1	european	european	ADJ
admet-2961	244	2	journal	journal	PROPN
admet-2961	244	3	of	of	ADP
admet-2961	244	4	drug	drug	NOUN
admet-2961	244	5	metabolism	metabolism	NOUN
admet-2961	244	6	and	and	CCONJ
admet-2961	244	7	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	244	8	44	44	NUM
admet-2961	244	9	(	(	PUNCT
admet-2961	244	10	2019	2019	NUM
admet-2961	244	11	)	)	PUNCT
admet-2961	244	12	817	817	NUM
admet-2961	244	13	-	-	SYM
admet-2961	244	14	826	826	NUM
admet-2961	244	15	.	.	PUNCT
admet-2961	245	1	http://doi.org/10.1007/s13318-019-00571-x	http://doi.org/10.1007/s13318-019-00571-x	NOUN
admet-2961	245	2	[	[	X
admet-2961	245	3	13	13	NUM
admet-2961	245	4	]	]	SYM
admet-2961	245	5	h.s	h.s	PROPN
admet-2961	245	6	.	.	PROPN
admet-2961	245	7	brown	brown	PROPN
admet-2961	245	8	,	,	PUNCT
admet-2961	245	9	m.	m.	NOUN
admet-2961	245	10	griffin	griffin	PROPN
admet-2961	245	11	,	,	PUNCT
admet-2961	245	12	j.b	j.b	PROPN
admet-2961	245	13	.	.	PROPN
admet-2961	245	14	houston	houston	PROPN
admet-2961	245	15	.	.	PUNCT
admet-2961	246	1	evaluation	evaluation	NOUN
admet-2961	246	2	of	of	ADP
admet-2961	246	3	cryopreserved	cryopreserve	VERB
admet-2961	246	4	human	human	ADJ
admet-2961	246	5	hepatocytes	hepatocyte	NOUN
admet-2961	246	6	as	as	ADP
admet-2961	246	7	an	an	DET
admet-2961	246	8	alternative	alternative	NOUN
admet-2961	246	9	in	in	ADP
admet-2961	246	10	vitro	vitro	X
admet-2961	246	11	system	system	NOUN
admet-2961	246	12	to	to	ADP
admet-2961	246	13	microsomes	microsome	NOUN
admet-2961	246	14	for	for	ADP
admet-2961	246	15	the	the	DET
admet-2961	246	16	prediction	prediction	NOUN
admet-2961	246	17	of	of	ADP
admet-2961	246	18	metabolic	metabolic	NOUN
admet-2961	246	19	clearance	clearance	NOUN
admet-2961	246	20	.	.	PUNCT
admet-2961	247	1	drug	drug	NOUN
admet-2961	247	2	metabolism	metabolism	NOUN
admet-2961	247	3	and	and	CCONJ
admet-2961	247	4	disposition	disposition	NOUN
admet-2961	247	5	35	35	NUM
admet-2961	247	6	(	(	PUNCT
admet-2961	247	7	2007	2007	NUM
admet-2961	247	8	)	)	PUNCT
admet-2961	247	9	293	293	NUM
admet-2961	247	10	-	-	SYM
admet-2961	247	11	301	301	NUM
admet-2961	247	12	.	.	PUNCT
admet-2961	248	1	http://doi.org/10.1124/dmd.106.011569	http://doi.org/10.1124/dmd.106.011569	PROPN
admet-2961	249	1	[	[	X
admet-2961	249	2	14	14	NUM
admet-2961	249	3	]	]	X
admet-2961	249	4	n.j	n.j	PROPN
admet-2961	249	5	.	.	PROPN
admet-2961	249	6	hewitt	hewitt	PROPN
admet-2961	249	7	,	,	PUNCT
admet-2961	249	8	m.j.g	m.j.g	PROPN
admet-2961	249	9	.	.	PUNCT
admet-2961	250	1	lechón	lechón	PROPN
admet-2961	250	2	,	,	PUNCT
admet-2961	250	3	j.b	j.b	PROPN
admet-2961	250	4	.	.	PROPN
admet-2961	250	5	houston	houston	PROPN
admet-2961	250	6	,	,	PUNCT
admet-2961	250	7	d.	d.	PROPN
admet-2961	250	8	hallifax	hallifax	PROPN
admet-2961	250	9	,	,	PUNCT
admet-2961	250	10	h.s	h.s	PROPN
admet-2961	250	11	.	.	PROPN
admet-2961	250	12	brown	brown	PROPN
admet-2961	250	13	,	,	PUNCT
admet-2961	250	14	p.	p.	NOUN
admet-2961	250	15	maurel	maurel	PROPN
admet-2961	250	16	,	,	PUNCT
admet-2961	250	17	j.g	j.g	PROPN
admet-2961	250	18	.	.	PROPN
admet-2961	250	19	kenna	kenna	PROPN
admet-2961	250	20	,	,	PUNCT
admet-2961	250	21	l.	l.	PROPN
admet-2961	250	22	gustavsson	gustavsson	PROPN
admet-2961	250	23	,	,	PUNCT
admet-2961	250	24	c.	c.	PROPN
admet-2961	250	25	lohmann	lohmann	PROPN
admet-2961	250	26	,	,	PUNCT
admet-2961	250	27	c.	c.	PROPN
admet-2961	250	28	skonberg	skonberg	PROPN
admet-2961	250	29	,	,	PUNCT
admet-2961	250	30	a.	a.	NOUN
admet-2961	250	31	guillouzo	guillouzo	PROPN
admet-2961	250	32	,	,	PUNCT
admet-2961	250	33	g.	g.	PROPN
admet-2961	250	34	tuschl	tuschl	PROPN
admet-2961	250	35	,	,	PUNCT
admet-2961	250	36	a.p	a.p	PROPN
admet-2961	250	37	.	.	PROPN
admet-2961	250	38	li	li	PROPN
admet-2961	250	39	,	,	PUNCT
admet-2961	250	40	e.	e.	PROPN
admet-2961	250	41	lecluyse	lecluyse	PROPN
admet-2961	250	42	,	,	PUNCT
admet-2961	250	43	g.m.m	g.m.m	NOUN
admet-2961	250	44	.	.	PUNCT
admet-2961	251	1	groothuis	groothuis	PROPN
admet-2961	251	2	,	,	PUNCT
admet-2961	251	3	j.g	j.g	PROPN
admet-2961	251	4	.	.	PROPN
admet-2961	251	5	hengstler	hengstler	PROPN
admet-2961	251	6	.	.	PUNCT
admet-2961	252	1	primary	primary	ADJ
admet-2961	252	2	hepatocytes	hepatocyte	NOUN
admet-2961	252	3	:	:	PUNCT
admet-2961	252	4	current	current	ADJ
admet-2961	252	5	understanding	understanding	NOUN
admet-2961	252	6	of	of	ADP
admet-2961	252	7	the	the	DET
admet-2961	252	8	regulation	regulation	NOUN
admet-2961	252	9	of	of	ADP
admet-2961	252	10	metabolic	metabolic	NOUN
admet-2961	252	11	enzymes	enzyme	NOUN
admet-2961	252	12	and	and	CCONJ
admet-2961	252	13	transporter	transporter	NOUN
admet-2961	252	14	proteins	protein	NOUN
admet-2961	252	15	,	,	PUNCT
admet-2961	252	16	and	and	CCONJ
admet-2961	252	17	pharmaceutical	pharmaceutical	NOUN
admet-2961	252	18	practice	practice	NOUN
admet-2961	252	19	for	for	ADP
admet-2961	252	20	the	the	DET
admet-2961	252	21	use	use	NOUN
admet-2961	252	22	of	of	ADP
admet-2961	252	23	hepatocytes	hepatocyte	NOUN
admet-2961	252	24	in	in	ADP
admet-2961	252	25	metabolism	metabolism	NOUN
admet-2961	252	26	,	,	PUNCT
admet-2961	252	27	enzyme	enzyme	NOUN
admet-2961	252	28	induction	induction	NOUN
admet-2961	252	29	,	,	PUNCT
admet-2961	252	30	transporter	transporter	NOUN
admet-2961	252	31	,	,	PUNCT
admet-2961	252	32	clearance	clearance	NOUN
admet-2961	252	33	,	,	PUNCT
admet-2961	252	34	and	and	CCONJ
admet-2961	252	35	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	252	36	studies	study	NOUN
admet-2961	252	37	.	.	PUNCT
admet-2961	253	1	drug	drug	NOUN
admet-2961	253	2	metabolism	metabolism	NOUN
admet-2961	253	3	reviews	review	NOUN
admet-2961	253	4	39	39	NUM
admet-2961	253	5	(	(	PUNCT
admet-2961	253	6	2007	2007	NUM
admet-2961	253	7	)	)	PUNCT
admet-2961	253	8	159	159	NUM
admet-2961	253	9	-	-	SYM
admet-2961	253	10	234	234	NUM
admet-2961	253	11	.	.	PUNCT
admet-2961	254	1	http://doi.org/10.1080/03602530601093489	http://doi.org/10.1080/03602530601093489	NOUN
admet-2961	255	1	[	[	X
admet-2961	255	2	15	15	NUM
admet-2961	255	3	]	]	X
admet-2961	255	4	a.	a.	NOUN
admet-2961	255	5	jetter	jetter	PROPN
admet-2961	255	6	,	,	PUNCT
admet-2961	255	7	g.a	g.a	PROPN
admet-2961	255	8	.	.	PROPN
admet-2961	255	9	kullak	kullak	PROPN
admet-2961	255	10	-	-	PROPN
admet-2961	255	11	ublick	ublick	NOUN
admet-2961	255	12	.	.	PUNCT
admet-2961	256	1	drugs	drug	NOUN
admet-2961	256	2	and	and	CCONJ
admet-2961	256	3	hepatic	hepatic	ADJ
admet-2961	256	4	transporters	transporter	NOUN
admet-2961	256	5	:	:	PUNCT
admet-2961	256	6	a	a	DET
admet-2961	256	7	review	review	NOUN
admet-2961	256	8	.	.	PUNCT
admet-2961	257	1	pharmacological	pharmacological	ADJ
admet-2961	257	2	research	research	NOUN
admet-2961	257	3	154	154	NUM
admet-2961	257	4	(	(	PUNCT
admet-2961	257	5	2020	2020	NUM
admet-2961	257	6	)	)	PUNCT
admet-2961	257	7	104234	104234	NUM
admet-2961	257	8	.	.	PUNCT
admet-2961	258	1	http://doi.org/10.1016/j.phrs.2019.04.018	http://doi.org/10.1016/j.phrs.2019.04.018	NOUN
admet-2961	259	1	[	[	X
admet-2961	259	2	16	16	NUM
admet-2961	259	3	]	]	PUNCT
admet-2961	259	4	r.	r.	PROPN
admet-2961	259	5	namdari	namdari	PROPN
admet-2961	259	6	,	,	PUNCT
admet-2961	259	7	k.	k.	PROPN
admet-2961	259	8	jones	jones	PROPN
admet-2961	259	9	,	,	PUNCT
admet-2961	259	10	s.s	s.s	PROPN
admet-2961	259	11	.	.	PROPN
admet-2961	259	12	chuang	chuang	PROPN
admet-2961	259	13	,	,	PUNCT
admet-2961	259	14	s.	s.	PROPN
admet-2961	259	15	van	van	PROPN
admet-2961	259	16	cruchten	cruchten	PROPN
admet-2961	259	17	,	,	PUNCT
admet-2961	259	18	z.	z.	PROPN
admet-2961	259	19	dincer	dincer	PROPN
admet-2961	259	20	,	,	PUNCT
admet-2961	259	21	n.	n.	PROPN
admet-2961	259	22	downes	downes	PROPN
admet-2961	259	23	,	,	PUNCT
admet-2961	259	24	l.f	l.f	PROPN
admet-2961	259	25	.	.	PROPN
admet-2961	259	26	mikkelsen	mikkelsen	PROPN
admet-2961	259	27	,	,	PUNCT
admet-2961	259	28	j.	j.	PROPN
admet-2961	259	29	harding	harding	PROPN
admet-2961	259	30	,	,	PUNCT
admet-2961	259	31	s.	s.	PROPN
admet-2961	259	32	jäckel	jäckel	PROPN
admet-2961	259	33	,	,	PUNCT
admet-2961	259	34	b.	b.	PROPN
admet-2961	259	35	jacobsen	jacobsen	PROPN
admet-2961	259	36	,	,	PUNCT
admet-2961	259	37	j.	j.	PROPN
admet-2961	259	38	kinyamu	kinyamu	PROPN
admet-2961	259	39	-	-	PUNCT
admet-2961	259	40	akunda	akunda	PROPN
admet-2961	259	41	,	,	PUNCT
admet-2961	259	42	a.	a.	NOUN
admet-2961	259	43	lortie	lortie	PROPN
admet-2961	259	44	,	,	PUNCT
admet-2961	259	45	s.	s.	PROPN
admet-2961	259	46	mhedhbi	mhedhbi	PROPN
admet-2961	259	47	,	,	PUNCT
admet-2961	259	48	s.	s.	PROPN
admet-2961	259	49	mohr	mohr	PROPN
admet-2961	259	50	,	,	PUNCT
admet-2961	259	51	m.w	m.w	PROPN
admet-2961	259	52	.	.	PROPN
admet-2961	259	53	schmitt	schmitt	PROPN
admet-2961	259	54	,	,	PUNCT
admet-2961	259	55	h.	h.	PROPN
admet-2961	259	56	prior	prior	ADV
admet-2961	259	57	.	.	PUNCT
admet-2961	260	1	species	specie	NOUN
admet-2961	260	2	selection	selection	NOUN
admet-2961	260	3	for	for	ADP
admet-2961	260	4	nonclinical	nonclinical	ADJ
admet-2961	260	5	safety	safety	NOUN
admet-2961	260	6	assessment	assessment	NOUN
admet-2961	260	7	of	of	ADP
admet-2961	260	8	drug	drug	NOUN
admet-2961	260	9	candidates	candidate	NOUN
admet-2961	260	10	:	:	PUNCT
admet-2961	260	11	examples	example	NOUN
admet-2961	260	12	of	of	ADP
admet-2961	260	13	current	current	ADJ
admet-2961	260	14	industry	industry	NOUN
admet-2961	260	15	practice	practice	NOUN
admet-2961	260	16	.	.	PUNCT
admet-2961	261	1	regulatory	regulatory	ADJ
admet-2961	261	2	toxicology	toxicology	NOUN
admet-2961	261	3	and	and	CCONJ
admet-2961	261	4	pharmacology	pharmacology	NOUN
admet-2961	261	5	126	126	NUM
admet-2961	261	6	(	(	PUNCT
admet-2961	261	7	2021	2021	NUM
admet-2961	261	8	)	)	PUNCT
admet-2961	261	9	105029	105029	NUM
admet-2961	261	10	.	.	PUNCT
admet-2961	262	1	http://doi.org/10.1016/j.yrtph.2021.105029	http://doi.org/10.1016/j.yrtph.2021.105029	PROPN
admet-2961	263	1	[	[	X
admet-2961	263	2	17	17	NUM
admet-2961	263	3	]	]	PUNCT
admet-2961	263	4	h.	h.	PROPN
admet-2961	263	5	prior	prior	PROPN
admet-2961	263	6	,	,	PUNCT
admet-2961	263	7	r.	r.	PROPN
admet-2961	263	8	haworth	haworth	PROPN
admet-2961	263	9	,	,	PUNCT
admet-2961	263	10	b.	b.	PROPN
admet-2961	263	11	labram	labram	PROPN
admet-2961	263	12	,	,	PUNCT
admet-2961	263	13	r.	r.	PROPN
admet-2961	263	14	roberts	roberts	PROPN
admet-2961	263	15	,	,	PUNCT
admet-2961	263	16	a.	a.	NOUN
admet-2961	263	17	wolfreys	wolfrey	NOUN
admet-2961	263	18	,	,	PUNCT
admet-2961	263	19	f.	f.	PROPN
admet-2961	263	20	sewell	sewell	PROPN
admet-2961	263	21	.	.	PUNCT
admet-2961	264	1	justification	justification	NOUN
admet-2961	264	2	for	for	ADP
admet-2961	264	3	species	specie	NOUN
admet-2961	264	4	selection	selection	NOUN
admet-2961	264	5	for	for	ADP
admet-2961	264	6	pharmaceutical	pharmaceutical	NOUN
admet-2961	264	7	toxicity	toxicity	NOUN
admet-2961	264	8	studies	study	NOUN
admet-2961	264	9	.	.	PUNCT
admet-2961	265	1	toxicology	toxicology	NOUN
admet-2961	265	2	research	research	NOUN
admet-2961	265	3	9	9	NUM
admet-2961	265	4	(	(	PUNCT
admet-2961	265	5	2021	2021	NUM
admet-2961	265	6	)	)	PUNCT
admet-2961	265	7	758	758	NUM
admet-2961	265	8	-	-	SYM
admet-2961	265	9	770	770	NUM
admet-2961	265	10	.	.	PUNCT
admet-2961	266	1	http://doi.org/10.1093/toxres/tfaa081	http://doi.org/10.1093/toxres/tfaa081	PRON
admet-2961	267	1	[	[	X
admet-2961	267	2	18	18	NUM
admet-2961	267	3	]	]	PUNCT
admet-2961	267	4	m.	m.	NOUN
admet-2961	267	5	darnell	darnell	PROPN
admet-2961	267	6	.	.	PUNCT
admet-2961	268	1	t.	t.	PROPN
admet-2961	268	2	schreiter	schreiter	PROPN
admet-2961	268	3	,	,	PUNCT
admet-2961	268	4	k.	k.	PROPN
admet-2961	268	5	zeilinger	zeilinger	PROPN
admet-2961	268	6	,	,	PUNCT
admet-2961	268	7	t.	t.	PROPN
admet-2961	268	8	urbaniak	urbaniak	PROPN
admet-2961	268	9	,	,	PUNCT
admet-2961	268	10	t.	t.	PROPN
admet-2961	268	11	söderdahl	söderdahl	PROPN
admet-2961	268	12	,	,	PUNCT
admet-2961	268	13	i.	i.	PROPN
admet-2961	268	14	rossberg	rossberg	PROPN
admet-2961	268	15	,	,	PUNCT
admet-2961	268	16	b.	b.	PROPN
admet-2961	268	17	dillnér	dillnér	PROPN
admet-2961	268	18	,	,	PUNCT
admet-2961	268	19	a.-l	a.-l	PROPN
admet-2961	268	20	.	.	PUNCT
admet-2961	269	1	berg	berg	PROPN
admet-2961	269	2	,	,	PUNCT
admet-2961	269	3	j.	j.	PROPN
admet-2961	269	4	c.	c.	PROPN
admet-2961	269	5	gerlach	gerlach	PROPN
admet-2961	269	6	,	,	PUNCT
admet-2961	269	7	t.	t.	PROPN
admet-2961	269	8	b.	b.	PROPN
admet-2961	269	9	andersson	andersson	PROPN
admet-2961	269	10	.	.	PUNCT
admet-2961	270	1	cytochrome	cytochrome	PROPN
admet-2961	270	2	p450	p450	NUM
admet-2961	270	3	induction	induction	NOUN
admet-2961	270	4	in	in	ADP
admet-2961	270	5	heparg	heparg	NOUN
admet-2961	270	6	cells	cell	NOUN
admet-2961	270	7	cultured	cultured	ADJ
admet-2961	270	8	in	in	ADP
admet-2961	270	9	a	a	DET
admet-2961	270	10	dynamic	dynamic	ADJ
admet-2961	270	11	3d	3d	NOUN
admet-2961	270	12	bioreactor	bioreactor	NOUN
admet-2961	270	13	.	.	PUNCT
admet-2961	271	1	drug	drug	NOUN
admet-2961	271	2	metabolism	metabolism	NOUN
admet-2961	271	3	reviews	review	NOUN
admet-2961	271	4	41	41	NUM
admet-2961	271	5	(	(	PUNCT
admet-2961	271	6	2009	2009	NUM
admet-2961	271	7	)	)	PUNCT
admet-2961	271	8	1131	1131	NUM
admet-2961	271	9	-	-	SYM
admet-2961	271	10	1138	1138	NUM
admet-2961	271	11	.	.	PUNCT
admet-2961	272	1	http://doi.org/10.1124/dmd.110.037721	http://doi.org/10.1124/dmd.110.037721	X
admet-2961	273	1	[	[	X
admet-2961	273	2	19	19	NUM
admet-2961	273	3	]	]	PUNCT
admet-2961	273	4	s.	s.	PROPN
admet-2961	273	5	anthérieu	anthérieu	PROPN
admet-2961	273	6	,	,	PUNCT
admet-2961	273	7	c.	c.	PROPN
admet-2961	273	8	chesné	chesné	PROPN
admet-2961	273	9	,	,	PUNCT
admet-2961	273	10	r.	r.	PROPN
admet-2961	273	11	li	li	PROPN
admet-2961	273	12	,	,	PUNCT
admet-2961	273	13	s.	s.	PROPN
admet-2961	273	14	camus	camus	PROPN
admet-2961	273	15	,	,	PUNCT
admet-2961	273	16	a.	a.	PROPN
admet-2961	273	17	lahoz	lahoz	PROPN
admet-2961	273	18	,	,	PUNCT
admet-2961	273	19	l.	l.	PROPN
admet-2961	273	20	picazo	picazo	PROPN
admet-2961	273	21	,	,	PUNCT
admet-2961	273	22	m.	m.	NOUN
admet-2961	273	23	turpeinen	turpeinen	PROPN
admet-2961	273	24	,	,	PUNCT
admet-2961	273	25	a.	a.	NOUN
admet-2961	273	26	tolonen	tolonen	PROPN
admet-2961	273	27	,	,	PUNCT
admet-2961	273	28	j.	j.	PROPN
admet-2961	273	29	uusitalo	uusitalo	PROPN
admet-2961	273	30	,	,	PUNCT
admet-2961	273	31	c.	c.	PROPN
admet-2961	273	32	guguen	guguen	PROPN
admet-2961	273	33	-	-	PUNCT
admet-2961	273	34	guillouzo	guillouzo	PROPN
admet-2961	273	35	,	,	PUNCT
admet-2961	273	36	a.	a.	NOUN
admet-2961	273	37	guillouzo	guillouzo	PROPN
admet-2961	273	38	.	.	PUNCT
admet-2961	274	1	stable	stable	ADJ
admet-2961	274	2	expression	expression	NOUN
admet-2961	274	3	,	,	PUNCT
admet-2961	274	4	activity	activity	NOUN
admet-2961	274	5	,	,	PUNCT
admet-2961	274	6	and	and	CCONJ
admet-2961	274	7	inducibility	inducibility	NOUN
admet-2961	274	8	of	of	ADP
admet-2961	274	9	cytochromes	cytochrome	NOUN
admet-2961	274	10	p450	p450	PROPN
admet-2961	274	11	in	in	ADP
admet-2961	274	12	differentiated	differentiated	ADJ
admet-2961	274	13	heparg	heparg	NOUN
admet-2961	274	14	cells	cell	NOUN
admet-2961	274	15	.	.	PUNCT
admet-2961	275	1	drug	drug	NOUN
admet-2961	275	2	metabolism	metabolism	NOUN
admet-2961	275	3	and	and	CCONJ
admet-2961	275	4	disposition	disposition	NOUN
admet-2961	275	5	38	38	NUM
admet-2961	275	6	(	(	PUNCT
admet-2961	275	7	2010	2010	NUM
admet-2961	275	8	)	)	PUNCT
admet-2961	275	9	516	516	NUM
admet-2961	275	10	-	-	SYM
admet-2961	275	11	525	525	NUM
admet-2961	275	12	.	.	PUNCT
admet-2961	276	1	http://doi.org/10.1124/dmd.109.030197	http://doi.org/10.1124/dmd.109.030197	PROPN
admet-2961	276	2	http://doi.org/10.1021/mp300476z	http://doi.org/10.1021/mp300476z	VERB
admet-2961	276	3	http://doi.org/10.3109/00498254.2012.669080	http://doi.org/10.3109/00498254.2012.669080	NOUN
admet-2961	276	4	http://doi.org/10.1517/17425250903405622	http://doi.org/10.1517/17425250903405622	PROPN
admet-2961	276	5	http://doi.org/10.2174/156802611794480873	http://doi.org/10.2174/156802611794480873	VERB
admet-2961	277	1	http://doi.org/10.1007/978-1-60761-688-7_3	http://doi.org/10.1007/978-1-60761-688-7_3	PROPN
admet-2961	277	2	http://doi.org/10.1007/978-1-60761-688-7_3	http://doi.org/10.1007/978-1-60761-688-7_3	PROPN
admet-2961	277	3	http://doi.org/10.1124/dmd.104.000125	http://doi.org/10.1124/dmd.104.000125	NOUN
admet-2961	277	4	http://doi.org/10.1016/s0009-2797(99)00088-5	http://doi.org/10.1016/s0009-2797(99)00088-5	PROPN
admet-2961	277	5	http://doi.org/10.1007/s13318-019-00571-x	http://doi.org/10.1007/s13318-019-00571-x	PROPN
admet-2961	277	6	http://doi.org/10.1124/dmd.106.011569	http://doi.org/10.1124/dmd.106.011569	NOUN
admet-2961	277	7	http://doi.org/10.1080/03602530601093489	http://doi.org/10.1080/03602530601093489	NOUN
admet-2961	277	8	http://doi.org/10.1016/j.phrs.2019.04.018	http://doi.org/10.1016/j.phrs.2019.04.018	PROPN
admet-2961	277	9	http://doi.org/10.1016/j.yrtph.2021.105029	http://doi.org/10.1016/j.yrtph.2021.105029	PROPN
admet-2961	277	10	http://doi.org/10.1093/toxres/tfaa081	http://doi.org/10.1093/toxres/tfaa081	PROPN
admet-2961	277	11	http://doi.org/10.1124/dmd.110.037721	http://doi.org/10.1124/dmd.110.037721	PROPN
admet-2961	277	12	http://doi.org/10.1124/dmd.109.030197	http://doi.org/10.1124/dmd.109.030197	PROPN
admet-2961	277	13	admet	admet	PROPN
admet-2961	277	14	&	&	CCONJ
admet-2961	277	15	dmpk	dmpk	PROPN
admet-2961	277	16	16(5	16(5	NUM
admet-2961	277	17	)	)	PUNCT
admet-2961	277	18	(	(	PUNCT
admet-2961	277	19	2025	2025	NUM
admet-2961	277	20	)	)	PUNCT
admet-2961	277	21	2961	2961	NUM
admet-2961	277	22	natural	natural	ADJ
admet-2961	277	23	molecules	molecule	NOUN
admet-2961	277	24	for	for	ADP
admet-2961	277	25	emt	emt	PROPN
admet-2961	277	26	treatment	treatment	NOUN
admet-2961	277	27	doi	doi	NOUN
admet-2961	277	28	:	:	PUNCT
admet-2961	277	29	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	277	30	13	13	NUM
admet-2961	277	31	[	[	SYM
admet-2961	277	32	20	20	NUM
admet-2961	277	33	]	]	X
admet-2961	277	34	b.	b.	PROPN
admet-2961	277	35	bonn	bonn	PROPN
admet-2961	277	36	,	,	PUNCT
admet-2961	277	37	p.	p.	PROPN
admet-2961	277	38	svanberg	svanberg	PROPN
admet-2961	277	39	,	,	PUNCT
admet-2961	277	40	a.	a.	PROPN
admet-2961	277	41	janefeldt	janefeldt	PROPN
admet-2961	277	42	,	,	PUNCT
admet-2961	277	43	i.	i.	PROPN
admet-2961	277	44	hultman	hultman	PROPN
admet-2961	277	45	,	,	PUNCT
admet-2961	277	46	k.	k.	PROPN
admet-2961	277	47	grime	grime	NOUN
admet-2961	277	48	.	.	PUNCT
admet-2961	278	1	determination	determination	NOUN
admet-2961	278	2	of	of	ADP
admet-2961	278	3	human	human	ADJ
admet-2961	278	4	hepatocyte	hepatocyte	NOUN
admet-2961	278	5	intrinsic	intrinsic	ADJ
admet-2961	278	6	clearance	clearance	NOUN
admet-2961	278	7	for	for	ADP
admet-2961	278	8	slowly	slowly	ADV
admet-2961	278	9	metabolized	metabolize	VERB
admet-2961	278	10	compounds	compound	NOUN
admet-2961	278	11	:	:	PUNCT
admet-2961	278	12	comparison	comparison	NOUN
admet-2961	278	13	of	of	ADP
admet-2961	278	14	a	a	DET
admet-2961	278	15	primary	primary	ADJ
admet-2961	278	16	hepatocyte	hepatocyte	NOUN
admet-2961	278	17	/	/	SYM
admet-2961	278	18	stromal	stromal	ADJ
admet-2961	278	19	cell	cell	NOUN
admet-2961	278	20	coculture	coculture	NOUN
admet-2961	278	21	with	with	ADP
admet-2961	278	22	plated	plate	VERB
admet-2961	278	23	primary	primary	ADJ
admet-2961	278	24	hepatocytes	hepatocyte	NOUN
admet-2961	278	25	and	and	CCONJ
admet-2961	278	26	heparg	heparg	NOUN
admet-2961	278	27	.	.	PUNCT
admet-2961	279	1	drug	drug	NOUN
admet-2961	279	2	metabolism	metabolism	NOUN
admet-2961	279	3	and	and	CCONJ
admet-2961	279	4	disposition	disposition	NOUN
admet-2961	279	5	44	44	NUM
admet-2961	279	6	(	(	PUNCT
admet-2961	279	7	2016	2016	NUM
admet-2961	279	8	)	)	PUNCT
admet-2961	279	9	527533	527533	NUM
admet-2961	279	10	.	.	PUNCT
admet-2961	280	1	http://doi.org/10.1124/dmd.115.067769	http://doi.org/10.1124/dmd.115.067769	NOUN
admet-2961	281	1	[	[	X
admet-2961	281	2	21	21	NUM
admet-2961	281	3	]	]	X
admet-2961	281	4	t.s	t.s	PROPN
admet-2961	281	5	.	.	PROPN
admet-2961	281	6	chan	chan	PROPN
admet-2961	281	7	,	,	PUNCT
admet-2961	281	8	h.	h.	PROPN
admet-2961	281	9	yu	yu	PROPN
admet-2961	281	10	,	,	PUNCT
admet-2961	281	11	a.	a.	PROPN
admet-2961	281	12	moore	moore	PROPN
admet-2961	281	13	,	,	PUNCT
admet-2961	281	14	s.r	s.r	PROPN
admet-2961	281	15	.	.	PROPN
admet-2961	281	16	khetani	khetani	PROPN
admet-2961	281	17	,	,	PUNCT
admet-2961	281	18	d.	d.	PROPN
admet-2961	281	19	tweedie	tweedie	PROPN
admet-2961	281	20	.	.	PUNCT
admet-2961	282	1	meeting	meet	VERB
admet-2961	282	2	the	the	DET
admet-2961	282	3	challenge	challenge	NOUN
admet-2961	282	4	of	of	ADP
admet-2961	282	5	predicting	predict	VERB
admet-2961	282	6	hepatic	hepatic	ADJ
admet-2961	282	7	clearance	clearance	NOUN
admet-2961	282	8	of	of	ADP
admet-2961	282	9	compounds	compound	NOUN
admet-2961	282	10	slowly	slowly	ADV
admet-2961	282	11	metabolized	metabolize	VERB
admet-2961	282	12	by	by	ADP
admet-2961	282	13	cytochrome	cytochrome	NOUN
admet-2961	282	14	p450	p450	PROPN
admet-2961	282	15	using	use	VERB
admet-2961	282	16	a	a	DET
admet-2961	282	17	novel	novel	ADJ
admet-2961	282	18	hepatocyte	hepatocyte	NOUN
admet-2961	282	19	model	model	NOUN
admet-2961	282	20	,	,	PUNCT
admet-2961	282	21	hepatopac	hepatopac	NOUN
admet-2961	282	22	.	.	PUNCT
admet-2961	283	1	drug	drug	NOUN
admet-2961	283	2	metabolism	metabolism	NOUN
admet-2961	283	3	and	and	CCONJ
admet-2961	283	4	disposition	disposition	NOUN
admet-2961	283	5	41	41	NUM
admet-2961	283	6	(	(	PUNCT
admet-2961	283	7	2013	2013	NUM
admet-2961	283	8	)	)	PUNCT
admet-2961	283	9	58	58	NUM
admet-2961	283	10	-	-	SYM
admet-2961	283	11	66	66	NUM
admet-2961	283	12	.	.	PUNCT
admet-2961	284	1	http://doi.org/10.1124/dmd.113.053397	http://doi.org/10.1124/dmd.113.053397	X
admet-2961	285	1	[	[	X
admet-2961	285	2	22	22	NUM
admet-2961	285	3	]	]	X
admet-2961	285	4	d.	d.	PROPN
admet-2961	285	5	ramsden	ramsden	PROPN
admet-2961	285	6	,	,	PUNCT
admet-2961	285	7	d.j	d.j	PROPN
admet-2961	285	8	.	.	PROPN
admet-2961	285	9	tweedie	tweedie	PROPN
admet-2961	285	10	,	,	PUNCT
admet-2961	285	11	t.s	t.s	PROPN
admet-2961	285	12	.	.	PROPN
admet-2961	285	13	chan	chan	PROPN
admet-2961	285	14	,	,	PUNCT
admet-2961	285	15	m.e	m.e	PROPN
admet-2961	285	16	.	.	PROPN
admet-2961	285	17	taub	taub	PROPN
admet-2961	285	18	,	,	PUNCT
admet-2961	285	19	y.	y.	PROPN
admet-2961	285	20	li	li	PROPN
admet-2961	285	21	.	.	PUNCT
admet-2961	286	1	bridging	bridge	VERB
admet-2961	286	2	in	in	ADP
admet-2961	286	3	vitro	vitro	X
admet-2961	286	4	and	and	CCONJ
admet-2961	286	5	in	in	ADP
admet-2961	286	6	vivo	vivo	ADJ
admet-2961	286	7	metabolism	metabolism	NOUN
admet-2961	286	8	and	and	CCONJ
admet-2961	286	9	transport	transport	NOUN
admet-2961	286	10	of	of	ADP
admet-2961	286	11	faldaprevir	faldaprevir	PROPN
admet-2961	286	12	in	in	ADP
admet-2961	286	13	human	human	NOUN
admet-2961	286	14	using	use	VERB
admet-2961	286	15	a	a	DET
admet-2961	286	16	novel	novel	NOUN
admet-2961	286	17	cocultured	coculture	VERB
admet-2961	286	18	human	human	ADJ
admet-2961	286	19	hepatocyte	hepatocyte	NOUN
admet-2961	286	20	system	system	NOUN
admet-2961	286	21	,	,	PUNCT
admet-2961	286	22	hepatopac	hepatopac	NOUN
admet-2961	286	23	.	.	PUNCT
admet-2961	287	1	drug	drug	NOUN
admet-2961	287	2	metabolism	metabolism	NOUN
admet-2961	287	3	and	and	CCONJ
admet-2961	287	4	disposition	disposition	NOUN
admet-2961	287	5	42	42	NUM
admet-2961	287	6	(	(	PUNCT
admet-2961	287	7	2014	2014	NUM
admet-2961	287	8	)	)	PUNCT
admet-2961	287	9	394	394	NUM
admet-2961	287	10	-	-	SYM
admet-2961	287	11	406	406	NUM
admet-2961	287	12	.	.	PUNCT
admet-2961	288	1	http://doi.org/10.1124/dmd.113.055897	http://doi.org/10.1124/dmd.113.055897	NOUN
admet-2961	289	1	[	[	X
admet-2961	289	2	23	23	NUM
admet-2961	289	3	]	]	X
admet-2961	289	4	d.	d.	PROPN
admet-2961	289	5	ramsden	ramsden	PROPN
admet-2961	289	6	,	,	PUNCT
admet-2961	289	7	d.j	d.j	PROPN
admet-2961	289	8	.	.	PROPN
admet-2961	289	9	tweedie	tweedie	PROPN
admet-2961	289	10	,	,	PUNCT
admet-2961	289	11	r.	r.	PROPN
admet-2961	289	12	st	st	PROPN
admet-2961	289	13	.	.	PROPN
admet-2961	289	14	george	george	PROPN
admet-2961	289	15	,	,	PUNCT
admet-2961	289	16	l.z	l.z	PROPN
admet-2961	289	17	.	.	PROPN
admet-2961	289	18	chen	chen	PROPN
admet-2961	289	19	,	,	PUNCT
admet-2961	289	20	y.	y.	PROPN
admet-2961	289	21	li	li	PROPN
admet-2961	289	22	.	.	PUNCT
admet-2961	290	1	generating	generate	VERB
admet-2961	290	2	an	an	DET
admet-2961	290	3	in	in	NOUN
admet-2961	290	4	vitro	vitro	NOUN
admet-2961	290	5	-	-	PUNCT
admet-2961	290	6	in	in	ADP
admet-2961	290	7	vivo	vivo	NOUN
admet-2961	290	8	correlation	correlation	NOUN
admet-2961	290	9	for	for	ADP
admet-2961	290	10	metabolism	metabolism	NOUN
admet-2961	290	11	and	and	CCONJ
admet-2961	290	12	liver	liver	NOUN
admet-2961	290	13	enrichment	enrichment	NOUN
admet-2961	290	14	of	of	ADP
admet-2961	290	15	a	a	DET
admet-2961	290	16	hepatitis	hepatitis	NOUN
admet-2961	290	17	c	c	PROPN
admet-2961	290	18	virus	virus	NOUN
admet-2961	290	19	drug	drug	NOUN
admet-2961	290	20	,	,	PUNCT
admet-2961	290	21	faldaprevir	faldaprevir	PROPN
admet-2961	290	22	,	,	PUNCT
admet-2961	290	23	using	use	VERB
admet-2961	290	24	a	a	DET
admet-2961	290	25	rat	rat	NOUN
admet-2961	290	26	hepatocyte	hepatocyte	NOUN
admet-2961	290	27	model	model	NOUN
admet-2961	290	28	(	(	PUNCT
admet-2961	290	29	hepatopac	hepatopac	NOUN
admet-2961	290	30	)	)	PUNCT
admet-2961	290	31	.	.	PUNCT
admet-2961	291	1	drug	drug	NOUN
admet-2961	291	2	metabolism	metabolism	NOUN
admet-2961	291	3	and	and	CCONJ
admet-2961	291	4	disposition	disposition	NOUN
admet-2961	291	5	42	42	NUM
admet-2961	291	6	(	(	PUNCT
admet-2961	291	7	2014	2014	NUM
admet-2961	291	8	)	)	PUNCT
admet-2961	291	9	407	407	NUM
admet-2961	291	10	-	-	SYM
admet-2961	291	11	414	414	NUM
admet-2961	291	12	.	.	PUNCT
admet-2961	292	1	http://doi.org/10.1124/dmd.113.055947	http://doi.org/10.1124/dmd.113.055947	PROPN
admet-2961	293	1	[	[	X
admet-2961	293	2	24	24	NUM
admet-2961	293	3	]	]	X
admet-2961	293	4	l.	l.	PROPN
admet-2961	293	5	di	di	PROPN
admet-2961	293	6	,	,	PUNCT
admet-2961	293	7	p.	p.	PROPN
admet-2961	293	8	trapa	trapa	PROPN
admet-2961	293	9	,	,	PUNCT
admet-2961	293	10	r.s	r.s	PROPN
admet-2961	293	11	.	.	PROPN
admet-2961	293	12	obach	obach	PROPN
admet-2961	293	13	,	,	PUNCT
admet-2961	293	14	k.	k.	PROPN
admet-2961	293	15	atkinson	atkinson	PROPN
admet-2961	293	16	,	,	PUNCT
admet-2961	293	17	y.a	y.a	PROPN
admet-2961	293	18	.	.	PROPN
admet-2961	293	19	bi	bi	PROPN
admet-2961	293	20	,	,	PUNCT
admet-2961	293	21	a.c	a.c	PROPN
admet-2961	293	22	.	.	PROPN
admet-2961	293	23	wolford	wolford	PROPN
admet-2961	293	24	,	,	PUNCT
admet-2961	293	25	b.	b.	PROPN
admet-2961	293	26	tan	tan	PROPN
admet-2961	293	27	,	,	PUNCT
admet-2961	293	28	t.s	t.s	PROPN
admet-2961	293	29	.	.	PROPN
admet-2961	293	30	mcdonald	mcdonald	PROPN
admet-2961	293	31	,	,	PUNCT
admet-2961	293	32	y.	y.	PROPN
admet-2961	293	33	lai	lai	PROPN
admet-2961	293	34	,	,	PUNCT
admet-2961	293	35	l.m	l.m	PROPN
admet-2961	293	36	.	.	PROPN
admet-2961	293	37	tremaine	tremaine	PROPN
admet-2961	293	38	.	.	PUNCT
admet-2961	294	1	a	a	DET
admet-2961	294	2	novel	novel	ADJ
admet-2961	294	3	relay	relay	NOUN
admet-2961	294	4	method	method	NOUN
admet-2961	294	5	for	for	ADP
admet-2961	294	6	determining	determine	VERB
admet-2961	294	7	low	low	ADJ
admet-2961	294	8	-	-	PUNCT
admet-2961	294	9	clearance	clearance	NOUN
admet-2961	294	10	values	value	NOUN
admet-2961	294	11	.	.	PUNCT
admet-2961	295	1	drug	drug	NOUN
admet-2961	295	2	metabolism	metabolism	NOUN
admet-2961	295	3	and	and	CCONJ
admet-2961	295	4	disposition	disposition	NOUN
admet-2961	295	5	40	40	NUM
admet-2961	295	6	(	(	PUNCT
admet-2961	295	7	2012	2012	NUM
admet-2961	295	8	)	)	PUNCT
admet-2961	295	9	1960	1960	NUM
admet-2961	295	10	-	-	SYM
admet-2961	295	11	1965	1965	NUM
admet-2961	295	12	.	.	PUNCT
admet-2961	296	1	http://doi.org/10.1124/dmd.112.046425	http://doi.org/10.1124/dmd.112.046425	PUNCT
admet-2961	297	1	[	[	X
admet-2961	297	2	25	25	NUM
admet-2961	297	3	]	]	PUNCT
admet-2961	297	4	l.	l.	PROPN
admet-2961	297	5	di	di	PROPN
admet-2961	297	6	,	,	PUNCT
admet-2961	297	7	r.s	r.s	PROPN
admet-2961	297	8	.	.	PROPN
admet-2961	297	9	obach	obach	PROPN
admet-2961	297	10	.	.	PUNCT
admet-2961	298	1	addressing	address	VERB
admet-2961	298	2	the	the	DET
admet-2961	298	3	challenges	challenge	NOUN
admet-2961	298	4	of	of	ADP
admet-2961	298	5	low	low	ADJ
admet-2961	298	6	clearance	clearance	NOUN
admet-2961	298	7	in	in	ADP
admet-2961	298	8	drug	drug	NOUN
admet-2961	298	9	research	research	NOUN
admet-2961	298	10	.	.	PUNCT
admet-2961	299	1	aaps	aap	NOUN
admet-2961	299	2	journal	journal	PROPN
admet-2961	299	3	17	17	NUM
admet-2961	299	4	(	(	PUNCT
admet-2961	299	5	2015	2015	NUM
admet-2961	299	6	)	)	PUNCT
admet-2961	299	7	352	352	NUM
admet-2961	299	8	-	-	SYM
admet-2961	299	9	357	357	NUM
admet-2961	299	10	.	.	PUNCT
admet-2961	300	1	http://doi.org/10.1208/s12248-014-9691-7	http://doi.org/10.1208/s12248-014-9691-7	PRON
admet-2961	301	1	[	[	X
admet-2961	301	2	26	26	NUM
admet-2961	301	3	]	]	X
admet-2961	301	4	k.a	k.a	PROPN
admet-2961	301	5	.	.	PROPN
admet-2961	301	6	hoffmaster	hoffmaster	PROPN
admet-2961	301	7	,	,	PUNCT
admet-2961	301	8	r.z	r.z	PROPN
admet-2961	301	9	.	.	PROPN
admet-2961	301	10	turncliff	turncliff	PROPN
admet-2961	301	11	,	,	PUNCT
admet-2961	301	12	e.l	e.l	PROPN
admet-2961	301	13	.	.	PROPN
admet-2961	301	14	lecluyse	lecluyse	PROPN
admet-2961	301	15	,	,	PUNCT
admet-2961	301	16	r.b	r.b	PROPN
admet-2961	301	17	.	.	PROPN
admet-2961	301	18	kim	kim	PROPN
admet-2961	301	19	,	,	PUNCT
admet-2961	301	20	p.j	p.j	PROPN
admet-2961	301	21	.	.	PROPN
admet-2961	301	22	meier	meier	PROPN
admet-2961	301	23	,	,	PUNCT
admet-2961	301	24	k.l.r	k.l.r	PROPN
admet-2961	301	25	.	.	PUNCT
admet-2961	301	26	brouwer	brouwer	PROPN
admet-2961	301	27	.	.	PUNCT
admet-2961	302	1	p	p	X
admet-2961	302	2	-	-	PUNCT
admet-2961	302	3	glycoprotein	glycoprotein	NOUN
admet-2961	302	4	expression	expression	NOUN
admet-2961	302	5	,	,	PUNCT
admet-2961	302	6	localization	localization	NOUN
admet-2961	302	7	,	,	PUNCT
admet-2961	302	8	and	and	CCONJ
admet-2961	302	9	function	function	NOUN
admet-2961	302	10	in	in	ADP
admet-2961	302	11	sandwich	sandwich	NOUN
admet-2961	302	12	-	-	PUNCT
admet-2961	302	13	cultured	cultured	ADJ
admet-2961	302	14	primary	primary	ADJ
admet-2961	302	15	rat	rat	NOUN
admet-2961	302	16	and	and	CCONJ
admet-2961	302	17	human	human	ADJ
admet-2961	302	18	hepatocytes	hepatocyte	NOUN
admet-2961	302	19	:	:	PUNCT
admet-2961	302	20	relevance	relevance	NOUN
admet-2961	302	21	to	to	ADP
admet-2961	302	22	the	the	DET
admet-2961	302	23	hepatobiliary	hepatobiliary	ADJ
admet-2961	302	24	disposition	disposition	NOUN
admet-2961	302	25	of	of	ADP
admet-2961	302	26	a	a	DET
admet-2961	302	27	model	model	NOUN
admet-2961	302	28	opioid	opioid	NOUN
admet-2961	302	29	peptide	peptide	NOUN
admet-2961	302	30	.	.	PUNCT
admet-2961	303	1	pharmaceutical	pharmaceutical	ADJ
admet-2961	303	2	research	research	NOUN
admet-2961	303	3	21	21	NUM
admet-2961	303	4	(	(	PUNCT
admet-2961	303	5	2004	2004	NUM
admet-2961	303	6	)	)	PUNCT
admet-2961	303	7	1294	1294	NUM
admet-2961	303	8	-	-	SYM
admet-2961	303	9	1302	1302	NUM
admet-2961	303	10	.	.	PUNCT
admet-2961	304	1	http://doi.org/10.1023/b:pham.0000033018.97745.0d	http://doi.org/10.1023/b:pham.0000033018.97745.0d	NOUN
admet-2961	305	1	[	[	X
admet-2961	305	2	27	27	NUM
admet-2961	305	3	]	]	PUNCT
admet-2961	305	4	k.	k.	PROPN
admet-2961	305	5	kanda	kanda	PROPN
admet-2961	305	6	,	,	PUNCT
admet-2961	305	7	r.	r.	PROPN
admet-2961	305	8	takahashi	takahashi	PROPN
admet-2961	305	9	,	,	PUNCT
admet-2961	305	10	t.	t.	PROPN
admet-2961	305	11	yoshikado	yoshikado	NOUN
admet-2961	305	12	,	,	PUNCT
admet-2961	305	13	y.	y.	PROPN
admet-2961	305	14	sugiyama	sugiyama	PROPN
admet-2961	305	15	.	.	PUNCT
admet-2961	306	1	total	total	ADJ
admet-2961	306	2	hepatocellular	hepatocellular	ADJ
admet-2961	306	3	disposition	disposition	NOUN
admet-2961	306	4	profiling	profiling	NOUN
admet-2961	306	5	of	of	ADP
admet-2961	306	6	rosuvastatin	rosuvastatin	NOUN
admet-2961	306	7	and	and	CCONJ
admet-2961	306	8	pitavastatin	pitavastatin	NOUN
admet-2961	306	9	in	in	ADP
admet-2961	306	10	sandwich	sandwich	NOUN
admet-2961	306	11	-	-	PUNCT
admet-2961	306	12	cultured	cultured	ADJ
admet-2961	306	13	human	human	ADJ
admet-2961	306	14	hepatocytes	hepatocyte	NOUN
admet-2961	306	15	.	.	PUNCT
admet-2961	307	1	drug	drug	NOUN
admet-2961	307	2	metabolism	metabolism	NOUN
admet-2961	307	3	and	and	CCONJ
admet-2961	307	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	307	5	33	33	NUM
admet-2961	307	6	(	(	PUNCT
admet-2961	307	7	2018	2018	NUM
admet-2961	307	8	)	)	PUNCT
admet-2961	307	9	164	164	NUM
admet-2961	307	10	-	-	SYM
admet-2961	307	11	172	172	NUM
admet-2961	307	12	.	.	PUNCT
admet-2961	308	1	http://doi.org/10.1016/j.dmpk.2018.04.001	http://doi.org/10.1016/j.dmpk.2018.04.001	X
admet-2961	309	1	[	[	X
admet-2961	309	2	28	28	NUM
admet-2961	309	3	]	]	X
admet-2961	309	4	b.	b.	PROPN
admet-2961	309	5	swift	swift	PROPN
admet-2961	309	6	,	,	PUNCT
admet-2961	309	7	n.d	n.d	PROPN
admet-2961	309	8	.	.	PROPN
admet-2961	309	9	pfeifer	pfeifer	PROPN
admet-2961	309	10	,	,	PUNCT
admet-2961	309	11	k.l.r	k.l.r	PROPN
admet-2961	309	12	.	.	PUNCT
admet-2961	309	13	brouwer	brouwer	PROPN
admet-2961	309	14	.	.	PUNCT
admet-2961	310	1	sandwich	sandwich	NOUN
admet-2961	310	2	-	-	PUNCT
admet-2961	310	3	cultured	cultured	ADJ
admet-2961	310	4	hepatocytes	hepatocyte	NOUN
admet-2961	310	5	:	:	PUNCT
admet-2961	310	6	an	an	DET
admet-2961	310	7	in	in	ADP
admet-2961	310	8	vitro	vitro	X
admet-2961	310	9	model	model	NOUN
admet-2961	310	10	to	to	PART
admet-2961	310	11	evaluate	evaluate	VERB
admet-2961	310	12	hepatobiliary	hepatobiliary	ADJ
admet-2961	310	13	transporter	transporter	NOUN
admet-2961	310	14	-	-	PUNCT
admet-2961	310	15	based	base	VERB
admet-2961	310	16	drug	drug	NOUN
admet-2961	310	17	interactions	interaction	NOUN
admet-2961	310	18	and	and	CCONJ
admet-2961	310	19	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	310	20	.	.	PUNCT
admet-2961	311	1	drug	drug	NOUN
admet-2961	311	2	metabolism	metabolism	NOUN
admet-2961	311	3	reviews	review	NOUN
admet-2961	311	4	42	42	NUM
admet-2961	311	5	(	(	PUNCT
admet-2961	311	6	2010	2010	NUM
admet-2961	311	7	)	)	PUNCT
admet-2961	311	8	446	446	NUM
admet-2961	311	9	-	-	SYM
admet-2961	311	10	471	471	NUM
admet-2961	311	11	.	.	PUNCT
admet-2961	312	1	http://doi.org/10.3109/03602530903491881	http://doi.org/10.3109/03602530903491881	PRON
admet-2961	313	1	[	[	X
admet-2961	313	2	29	29	NUM
admet-2961	313	3	]	]	X
admet-2961	313	4	j.h	j.h	PROPN
admet-2961	313	5	.	.	PROPN
admet-2961	313	6	brown	brown	PROPN
admet-2961	313	7	,	,	PUNCT
admet-2961	313	8	p.	p.	PROPN
admet-2961	313	9	das	das	PROPN
admet-2961	313	10	,	,	PUNCT
admet-2961	313	11	m.d	m.d	PROPN
admet-2961	313	12	.	.	PROPN
admet-2961	313	13	divito	divito	PROPN
admet-2961	313	14	,	,	PUNCT
admet-2961	313	15	d.	d.	PROPN
admet-2961	313	16	ivancic	ivancic	PROPN
admet-2961	313	17	,	,	PUNCT
admet-2961	313	18	l.p	l.p	PROPN
admet-2961	313	19	.	.	PROPN
admet-2961	313	20	tan	tan	PROPN
admet-2961	313	21	,	,	PUNCT
admet-2961	313	22	j.a	j.a	PROPN
admet-2961	313	23	.	.	PROPN
admet-2961	313	24	wertheim	wertheim	PROPN
admet-2961	313	25	.	.	PUNCT
admet-2961	314	1	nanofibrous	nanofibrous	ADJ
admet-2961	314	2	plga	plga	NOUN
admet-2961	314	3	electrospun	electrospun	NOUN
admet-2961	314	4	scaffolds	scaffold	NOUN
admet-2961	314	5	modified	modify	VERB
admet-2961	314	6	with	with	ADP
admet-2961	314	7	type	type	NOUN
admet-2961	315	1	i	i	PRON
admet-2961	315	2	collagen	collagen	NOUN
admet-2961	315	3	influence	influence	NOUN
admet-2961	315	4	hepatocyte	hepatocyte	NOUN
admet-2961	315	5	function	function	NOUN
admet-2961	315	6	and	and	CCONJ
admet-2961	315	7	support	support	NOUN
admet-2961	315	8	viability	viability	NOUN
admet-2961	315	9	in	in	ADP
admet-2961	315	10	vitro	vitro	X
admet-2961	315	11	.	.	PUNCT
admet-2961	316	1	acta	acta	PROPN
admet-2961	316	2	biomaterialia	biomaterialia	PROPN
admet-2961	316	3	73	73	NUM
admet-2961	316	4	(	(	PUNCT
admet-2961	316	5	2018	2018	NUM
admet-2961	316	6	)	)	PUNCT
admet-2961	316	7	217	217	NUM
admet-2961	316	8	-	-	SYM
admet-2961	316	9	227	227	NUM
admet-2961	316	10	.	.	PUNCT
admet-2961	317	1	http://doi.org/10.1016/j.actbio.2018.02.009	http://doi.org/10.1016/j.actbio.2018.02.009	X
admet-2961	318	1	[	[	X
admet-2961	318	2	30	30	NUM
admet-2961	318	3	]	]	PUNCT
admet-2961	318	4	m.	m.	NOUN
admet-2961	318	5	oorts	oort	NOUN
admet-2961	318	6	,	,	PUNCT
admet-2961	318	7	j.	j.	PROPN
admet-2961	318	8	keemink	keemink	PROPN
admet-2961	318	9	,	,	PUNCT
admet-2961	318	10	n.	n.	PROPN
admet-2961	318	11	deferm	deferm	PROPN
admet-2961	318	12	,	,	PUNCT
admet-2961	318	13	r.	r.	PROPN
admet-2961	318	14	adriaensen	adriaensen	PROPN
admet-2961	318	15	,	,	PUNCT
admet-2961	318	16	l.	l.	PROPN
admet-2961	318	17	richert	richert	PROPN
admet-2961	318	18	,	,	PUNCT
admet-2961	318	19	p.	p.	NOUN
admet-2961	318	20	augustijns	augustijns	NOUN
admet-2961	318	21	,	,	PUNCT
admet-2961	318	22	p.	p.	PROPN
admet-2961	318	23	annaert	annaert	NOUN
admet-2961	318	24	.	.	PUNCT
admet-2961	319	1	extra	extra	ADJ
admet-2961	319	2	collagen	collagen	NOUN
admet-2961	319	3	overlay	overlay	NOUN
admet-2961	319	4	prolongs	prolong	VERB
admet-2961	319	5	the	the	DET
admet-2961	319	6	differentiated	differentiated	ADJ
admet-2961	319	7	phenotype	phenotype	NOUN
admet-2961	319	8	in	in	ADP
admet-2961	319	9	sandwich	sandwich	NOUN
admet-2961	319	10	-	-	PUNCT
admet-2961	319	11	cultured	cultured	ADJ
admet-2961	319	12	rat	rat	NOUN
admet-2961	319	13	hepatocytes	hepatocyte	NOUN
admet-2961	319	14	.	.	PUNCT
admet-2961	320	1	journal	journal	NOUN
admet-2961	320	2	of	of	ADP
admet-2961	320	3	pharmacological	pharmacological	ADJ
admet-2961	320	4	and	and	CCONJ
admet-2961	320	5	toxicological	toxicological	ADJ
admet-2961	320	6	methods	method	NOUN
admet-2961	320	7	90	90	NUM
admet-2961	320	8	(	(	PUNCT
admet-2961	320	9	2018	2018	NUM
admet-2961	320	10	)	)	PUNCT
admet-2961	320	11	31	31	NUM
admet-2961	320	12	-	-	SYM
admet-2961	320	13	38	38	NUM
admet-2961	320	14	.	.	PUNCT
admet-2961	321	1	http://doi.org/10.1016/j.vascn.2017.10.007	http://doi.org/10.1016/j.vascn.2017.10.007	ADJ
admet-2961	321	2	[	[	X
admet-2961	321	3	31	31	NUM
admet-2961	321	4	]	]	PUNCT
admet-2961	321	5	j.	j.	PROPN
admet-2961	321	6	keemink	keemink	PROPN
admet-2961	321	7	,	,	PUNCT
admet-2961	321	8	m.	m.	NOUN
admet-2961	321	9	oorts	oort	NOUN
admet-2961	321	10	,	,	PUNCT
admet-2961	321	11	p.	p.	PROPN
admet-2961	321	12	annaert	annaert	NOUN
admet-2961	321	13	.	.	PUNCT
admet-2961	322	1	primary	primary	ADJ
admet-2961	322	2	hepatocytes	hepatocyte	NOUN
admet-2961	322	3	in	in	ADP
admet-2961	322	4	sandwich	sandwich	NOUN
admet-2961	322	5	culture	culture	NOUN
admet-2961	322	6	.	.	PUNCT
admet-2961	323	1	methods	method	NOUN
admet-2961	323	2	in	in	ADP
admet-2961	323	3	molecular	molecular	ADJ
admet-2961	323	4	biology	biology	NOUN
admet-2961	323	5	1250	1250	NUM
admet-2961	323	6	(	(	PUNCT
admet-2961	323	7	2014	2014	NUM
admet-2961	323	8	)	)	PUNCT
admet-2961	323	9	175	175	NUM
admet-2961	323	10	-	-	SYM
admet-2961	323	11	188	188	NUM
admet-2961	323	12	.	.	PUNCT
admet-2961	324	1	http://doi.org/10.1007/978-1-4939-2074-7_12	http://doi.org/10.1007/978-1-4939-2074-7_12	PUNCT
admet-2961	325	1	[	[	X
admet-2961	325	2	32	32	NUM
admet-2961	325	3	]	]	PUNCT
admet-2961	325	4	p.	p.	NOUN
admet-2961	325	5	lancett	lancett	PROPN
admet-2961	325	6	,	,	PUNCT
admet-2961	325	7	b.	b.	PROPN
admet-2961	325	8	williamson	williamson	PROPN
admet-2961	325	9	,	,	PUNCT
admet-2961	325	10	p.	p.	PROPN
admet-2961	325	11	barton	barton	PROPN
admet-2961	325	12	,	,	PUNCT
admet-2961	325	13	r.j	r.j	PROPN
admet-2961	325	14	.	.	PROPN
admet-2961	325	15	riley	riley	PROPN
admet-2961	325	16	.	.	PUNCT
admet-2961	326	1	development	development	NOUN
admet-2961	326	2	and	and	CCONJ
admet-2961	326	3	characterization	characterization	NOUN
admet-2961	326	4	of	of	ADP
admet-2961	326	5	a	a	DET
admet-2961	326	6	human	human	ADJ
admet-2961	326	7	hepatocyte	hepatocyte	NOUN
admet-2961	326	8	low	low	ADJ
admet-2961	326	9	intrinsic	intrinsic	ADJ
admet-2961	326	10	clearance	clearance	NOUN
admet-2961	326	11	assay	assay	VERB
admet-2961	326	12	for	for	ADP
admet-2961	326	13	use	use	NOUN
admet-2961	326	14	in	in	ADP
admet-2961	326	15	drug	drug	NOUN
admet-2961	326	16	discovery	discovery	NOUN
admet-2961	326	17	.	.	PUNCT
admet-2961	327	1	drug	drug	NOUN
admet-2961	327	2	metabolism	metabolism	NOUN
admet-2961	327	3	and	and	CCONJ
admet-2961	327	4	disposition	disposition	NOUN
admet-2961	327	5	46	46	NUM
admet-2961	327	6	(	(	PUNCT
admet-2961	327	7	2018	2018	NUM
admet-2961	327	8	)	)	PUNCT
admet-2961	327	9	1169	1169	NUM
admet-2961	327	10	-	-	SYM
admet-2961	327	11	1178	1178	NUM
admet-2961	327	12	.	.	PUNCT
admet-2961	328	1	http://doi.org/10.1124/dmd.118.081596	http://doi.org/10.1124/dmd.118.081596	NOUN
admet-2961	328	2	[	[	X
admet-2961	328	3	33	33	NUM
admet-2961	328	4	]	]	X
admet-2961	328	5	n.	n.	NOUN
admet-2961	328	6	treijtel	treijtel	NOUN
admet-2961	328	7	,	,	PUNCT
admet-2961	328	8	a.	a.	NOUN
admet-2961	328	9	barendregt	barendregt	PROPN
admet-2961	328	10	,	,	PUNCT
admet-2961	328	11	a.p	a.p	PROPN
admet-2961	328	12	.	.	PROPN
admet-2961	328	13	freidig	freidig	PROPN
admet-2961	328	14	,	,	PUNCT
admet-2961	328	15	b.j	b.j	PROPN
admet-2961	328	16	.	.	PROPN
admet-2961	328	17	blaauboer	blaauboer	PROPN
admet-2961	328	18	,	,	PUNCT
admet-2961	328	19	j.c.h	j.c.h	ADJ
admet-2961	328	20	.	.	PUNCT
admet-2961	329	1	van	van	PROPN
admet-2961	329	2	eijkeren	eijkeren	PROPN
admet-2961	329	3	.	.	PUNCT
admet-2961	330	1	modeling	model	VERB
admet-2961	330	2	the	the	DET
admet-2961	330	3	in	in	ADV
admet-2961	330	4	vitro	vitro	X
admet-2961	330	5	intrinsic	intrinsic	ADJ
admet-2961	330	6	clearance	clearance	NOUN
admet-2961	330	7	of	of	ADP
admet-2961	330	8	the	the	DET
admet-2961	330	9	slowly	slowly	ADV
admet-2961	330	10	metabolized	metabolize	VERB
admet-2961	330	11	compound	compound	NOUN
admet-2961	330	12	tolbutamide	tolbutamide	NOUN
admet-2961	330	13	determined	determine	VERB
admet-2961	330	14	in	in	ADP
admet-2961	330	15	sandwich	sandwich	NOUN
admet-2961	330	16	-	-	PUNCT
admet-2961	330	17	cultured	cultured	ADJ
admet-2961	330	18	rat	rat	NOUN
admet-2961	330	19	hepatocytes	hepatocyte	NOUN
admet-2961	330	20	.	.	PUNCT
admet-2961	331	1	drug	drug	NOUN
admet-2961	331	2	metabolism	metabolism	NOUN
admet-2961	331	3	and	and	CCONJ
admet-2961	331	4	disposition	disposition	NOUN
admet-2961	331	5	32	32	NUM
admet-2961	331	6	(	(	PUNCT
admet-2961	331	7	2004	2004	NUM
admet-2961	331	8	)	)	PUNCT
admet-2961	331	9	884	884	NUM
admet-2961	331	10	-	-	SYM
admet-2961	331	11	891	891	NUM
admet-2961	331	12	.	.	PUNCT
admet-2961	332	1	http://doi.org/10.1124/dmd.32.8.884	http://doi.org/10.1124/dmd.32.8.884	NOUN
admet-2961	332	2	[	[	X
admet-2961	332	3	34	34	NUM
admet-2961	332	4	]	]	X
admet-2961	332	5	w.	w.	PROPN
admet-2961	332	6	xiao	xiao	PROPN
admet-2961	332	7	,	,	PUNCT
admet-2961	332	8	g.	g.	PROPN
admet-2961	332	9	perry	perry	PROPN
admet-2961	332	10	,	,	PUNCT
admet-2961	332	11	k.	k.	PROPN
admet-2961	332	12	komori	komori	PROPN
admet-2961	332	13	,	,	PUNCT
admet-2961	332	14	y.	y.	PROPN
admet-2961	332	15	sakai	sakai	PROPN
admet-2961	332	16	.	.	PUNCT
admet-2961	333	1	new	new	ADJ
admet-2961	333	2	physiologically	physiologically	ADV
admet-2961	333	3	-	-	PUNCT
admet-2961	333	4	relevant	relevant	ADJ
admet-2961	333	5	liver	liver	NOUN
admet-2961	333	6	tissue	tissue	NOUN
admet-2961	333	7	model	model	NOUN
admet-2961	333	8	based	base	VERB
admet-2961	333	9	on	on	ADP
admet-2961	333	10	hierarchically	hierarchically	ADV
admet-2961	333	11	cocultured	coculture	VERB
admet-2961	333	12	primary	primary	ADJ
admet-2961	333	13	rat	rat	NOUN
admet-2961	333	14	hepatocytes	hepatocyte	NOUN
admet-2961	333	15	with	with	ADP
admet-2961	333	16	liver	liver	NOUN
admet-2961	333	17	endothelial	endothelial	ADJ
admet-2961	333	18	cells	cell	NOUN
admet-2961	333	19	.	.	PUNCT
admet-2961	334	1	integrative	integrative	ADJ
admet-2961	334	2	biology	biology	NOUN
admet-2961	334	3	(	(	PUNCT
admet-2961	334	4	united	united	ADJ
admet-2961	334	5	kingdom	kingdom	PROPN
admet-2961	334	6	)	)	PUNCT
admet-2961	334	7	7	7	NUM
admet-2961	334	8	(	(	PUNCT
admet-2961	334	9	2015	2015	NUM
admet-2961	334	10	)	)	PUNCT
admet-2961	334	11	33	33	NUM
admet-2961	334	12	-	-	SYM
admet-2961	334	13	45	45	NUM
admet-2961	334	14	.	.	PUNCT
admet-2961	335	1	http://doi.org/10.1039/c5ib00170f	http://doi.org/10.1039/c5ib00170f	PUNCT
admet-2961	336	1	[	[	X
admet-2961	336	2	35	35	NUM
admet-2961	336	3	]	]	X
admet-2961	336	4	r.	r.	PROPN
admet-2961	336	5	kostadinova	kostadinova	PROPN
admet-2961	336	6	,	,	PUNCT
admet-2961	336	7	f.	f.	PROPN
admet-2961	336	8	boess	boess	PROPN
admet-2961	336	9	,	,	PUNCT
admet-2961	336	10	d.	d.	PROPN
admet-2961	336	11	applegate	applegate	PROPN
admet-2961	336	12	,	,	PUNCT
admet-2961	336	13	l.	l.	PROPN
admet-2961	336	14	suter	suter	PROPN
admet-2961	336	15	,	,	PUNCT
admet-2961	336	16	t.	t.	PROPN
admet-2961	336	17	weiser	weiser	PROPN
admet-2961	336	18	,	,	PUNCT
admet-2961	336	19	t.	t.	PROPN
admet-2961	336	20	singer	singer	PROPN
admet-2961	336	21	,	,	PUNCT
admet-2961	336	22	b.	b.	PROPN
admet-2961	336	23	naughton	naughton	PROPN
admet-2961	336	24	,	,	PUNCT
admet-2961	336	25	a.	a.	PROPN
admet-2961	336	26	roth	roth	PROPN
admet-2961	336	27	.	.	PUNCT
admet-2961	337	1	a	a	DET
admet-2961	337	2	long	long	ADJ
admet-2961	337	3	-	-	PUNCT
admet-2961	337	4	term	term	NOUN
admet-2961	337	5	three	three	NUM
admet-2961	337	6	dimensional	dimensional	ADJ
admet-2961	337	7	liver	liver	NOUN
admet-2961	337	8	co	co	NOUN
admet-2961	337	9	-	-	NOUN
admet-2961	337	10	culture	culture	ADJ
admet-2961	337	11	system	system	NOUN
admet-2961	337	12	for	for	ADP
admet-2961	337	13	improved	improved	ADJ
admet-2961	337	14	prediction	prediction	NOUN
admet-2961	337	15	of	of	ADP
admet-2961	337	16	clinically	clinically	ADV
admet-2961	337	17	relevant	relevant	ADJ
admet-2961	337	18	drug	drug	NOUN
admet-2961	337	19	-	-	PUNCT
admet-2961	337	20	induced	induce	VERB
admet-2961	337	21	hepatotoxicity	hepatotoxicity	NOUN
admet-2961	337	22	.	.	PUNCT
admet-2961	338	1	toxicology	toxicology	NOUN
admet-2961	338	2	and	and	CCONJ
admet-2961	338	3	applied	apply	VERB
admet-2961	338	4	pharmacology	pharmacology	NOUN
admet-2961	338	5	268	268	NUM
admet-2961	338	6	(	(	PUNCT
admet-2961	338	7	2013	2013	NUM
admet-2961	338	8	)	)	PUNCT
admet-2961	338	9	1	1	NUM
admet-2961	338	10	-	-	SYM
admet-2961	338	11	16	16	NUM
admet-2961	338	12	.	.	PUNCT
admet-2961	339	1	http://doi.org/10.1016/j.taap.2013.01.012	http://doi.org/10.1016/j.taap.2013.01.012	PROPN
admet-2961	339	2	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	ADJ
admet-2961	339	3	http://doi.org/10.1124/dmd.115.067769	http://doi.org/10.1124/dmd.115.067769	NOUN
admet-2961	339	4	http://doi.org/10.1124/dmd.113.053397	http://doi.org/10.1124/dmd.113.053397	NOUN
admet-2961	339	5	http://doi.org/10.1124/dmd.113.055897	http://doi.org/10.1124/dmd.113.055897	PROPN
admet-2961	339	6	http://doi.org/10.1124/dmd.113.055947	http://doi.org/10.1124/dmd.113.055947	PROPN
admet-2961	339	7	http://doi.org/10.1124/dmd.112.046425	http://doi.org/10.1124/dmd.112.046425	PROPN
admet-2961	339	8	http://doi.org/10.1208/s12248-014-9691-7	http://doi.org/10.1208/s12248-014-9691-7	NUM
admet-2961	339	9	http://doi.org/10.1023/b:pham.0000033018.97745.0d	http://doi.org/10.1023/b:pham.0000033018.97745.0d	NOUN
admet-2961	339	10	http://doi.org/10.1016/j.dmpk.2018.04.001	http://doi.org/10.1016/j.dmpk.2018.04.001	NUM
admet-2961	340	1	http://doi.org/10.3109/03602530903491881	http://doi.org/10.3109/03602530903491881	NOUN
admet-2961	341	1	http://doi.org/10.1016/j.actbio.2018.02.009	http://doi.org/10.1016/j.actbio.2018.02.009	NOUN
admet-2961	341	2	http://doi.org/10.1016/j.vascn.2017.10.007	http://doi.org/10.1016/j.vascn.2017.10.007	VERB
admet-2961	341	3	http://doi.org/10.1007/978-1-4939-2074-7_12	http://doi.org/10.1007/978-1-4939-2074-7_12	NOUN
admet-2961	341	4	http://doi.org/10.1124/dmd.118.081596	http://doi.org/10.1124/dmd.118.081596	ADP
admet-2961	341	5	http://doi.org/10.1124/dmd.32.8.884	http://doi.org/10.1124/dmd.32.8.884	PROPN
admet-2961	341	6	http://doi.org/10.1039/c5ib00170f	http://doi.org/10.1039/c5ib00170f	PROPN
admet-2961	341	7	http://doi.org/10.1016/j.taap.2013.01.012	http://doi.org/10.1016/j.taap.2013.01.012	PROPN
admet-2961	341	8	j.	j.	PROPN
admet-2961	341	9	pu	pu	PROPN
admet-2961	341	10	et	et	PROPN
admet-2961	341	11	al	al	PROPN
admet-2961	341	12	.	.	PROPN
admet-2961	341	13	admet	admet	PROPN
admet-2961	341	14	&	&	CCONJ
admet-2961	341	15	dmpk	dmpk	PROPN
admet-2961	341	16	13(5	13(5	NUM
admet-2961	341	17	)	)	PUNCT
admet-2961	341	18	(	(	PUNCT
admet-2961	341	19	2025	2025	NUM
admet-2961	341	20	)	)	PUNCT
admet-2961	341	21	2961	2961	NUM
admet-2961	341	22	14	14	NUM
admet-2961	342	1	[	[	X
admet-2961	342	2	36	36	NUM
admet-2961	342	3	]	]	X
admet-2961	342	4	y.	y.	PROPN
admet-2961	342	5	liu	liu	PROPN
admet-2961	342	6	,	,	PUNCT
admet-2961	342	7	j.	j.	PROPN
admet-2961	342	8	wei	wei	PROPN
admet-2961	342	9	,	,	PUNCT
admet-2961	342	10	j.	j.	PROPN
admet-2961	342	11	lu	lu	PROPN
admet-2961	342	12	,	,	PUNCT
admet-2961	342	13	d.	d.	PROPN
admet-2961	342	14	lei	lei	PROPN
admet-2961	342	15	,	,	PUNCT
admet-2961	342	16	s.	s.	PROPN
admet-2961	342	17	yan	yan	PROPN
admet-2961	342	18	,	,	PUNCT
admet-2961	342	19	x.	x.	PROPN
admet-2961	342	20	li	li	PROPN
admet-2961	342	21	.	.	PROPN
admet-2961	342	22	micropatterned	micropatterne	VERB
admet-2961	342	23	coculture	coculture	NOUN
admet-2961	342	24	of	of	ADP
admet-2961	342	25	hepatocytes	hepatocyte	NOUN
admet-2961	342	26	on	on	ADP
admet-2961	342	27	electrospun	electrospun	NOUN
admet-2961	342	28	fibers	fiber	NOUN
admet-2961	342	29	as	as	ADP
admet-2961	342	30	a	a	DET
admet-2961	342	31	potential	potential	NOUN
admet-2961	342	32	in	in	ADP
admet-2961	342	33	vitro	vitro	X
admet-2961	342	34	model	model	NOUN
admet-2961	342	35	for	for	ADP
admet-2961	342	36	predictive	predictive	ADJ
admet-2961	342	37	drug	drug	NOUN
admet-2961	342	38	metabolism	metabolism	NOUN
admet-2961	342	39	.	.	PUNCT
admet-2961	343	1	materials	material	NOUN
admet-2961	343	2	science	science	NOUN
admet-2961	343	3	and	and	CCONJ
admet-2961	343	4	engineering	engineering	NOUN
admet-2961	343	5	c	c	PROPN
admet-2961	343	6	63	63	NUM
admet-2961	343	7	(	(	PUNCT
admet-2961	343	8	2016	2016	NUM
admet-2961	343	9	)	)	PUNCT
admet-2961	343	10	474	474	NUM
admet-2961	343	11	-	-	SYM
admet-2961	343	12	484	484	NUM
admet-2961	343	13	.	.	PUNCT
admet-2961	344	1	http://doi.org/10.1016/j.msec.2016.03.025	http://doi.org/10.1016/j.msec.2016.03.025	VERB
admet-2961	344	2	[	[	PUNCT
admet-2961	344	3	37	37	NUM
admet-2961	344	4	]	]	PUNCT
admet-2961	344	5	o.	o.	NOUN
admet-2961	344	6	ukairo	ukairo	NOUN
admet-2961	344	7	,	,	PUNCT
admet-2961	344	8	c.	c.	PROPN
admet-2961	344	9	kanchagar	kanchagar	PROPN
admet-2961	344	10	,	,	PUNCT
admet-2961	344	11	a.	a.	PROPN
admet-2961	344	12	moore	moore	PROPN
admet-2961	344	13	,	,	PUNCT
admet-2961	344	14	j.	j.	PROPN
admet-2961	344	15	shi	shi	PROPN
admet-2961	344	16	,	,	PUNCT
admet-2961	344	17	j.	j.	PROPN
admet-2961	344	18	gaffney	gaffney	PROPN
admet-2961	344	19	,	,	PUNCT
admet-2961	344	20	s.	s.	PROPN
admet-2961	344	21	aoyama	aoyama	PROPN
admet-2961	344	22	,	,	PUNCT
admet-2961	344	23	k.	k.	PROPN
admet-2961	344	24	rose	rise	VERB
admet-2961	344	25	,	,	PUNCT
admet-2961	344	26	s.	s.	PROPN
admet-2961	344	27	krzyzewski	krzyzewski	PROPN
admet-2961	344	28	,	,	PUNCT
admet-2961	344	29	j.	j.	PROPN
admet-2961	344	30	mcgeehan	mcgeehan	PROPN
admet-2961	344	31	,	,	PUNCT
admet-2961	344	32	m.e	m.e	PROPN
admet-2961	344	33	.	.	PROPN
admet-2961	344	34	andersen	andersen	PROPN
admet-2961	344	35	,	,	PUNCT
admet-2961	344	36	s.r	s.r	PROPN
admet-2961	344	37	.	.	PROPN
admet-2961	344	38	khetani	khetani	PROPN
admet-2961	344	39	,	,	PUNCT
admet-2961	344	40	e.l	e.l	PROPN
admet-2961	344	41	.	.	PROPN
admet-2961	344	42	lecluyse	lecluyse	PROPN
admet-2961	344	43	.	.	PUNCT
admet-2961	345	1	long	long	ADJ
admet-2961	345	2	-	-	PUNCT
admet-2961	345	3	term	term	NOUN
admet-2961	345	4	stability	stability	NOUN
admet-2961	345	5	of	of	ADP
admet-2961	345	6	primary	primary	ADJ
admet-2961	345	7	rat	rat	NOUN
admet-2961	345	8	hepatocytes	hepatocyte	NOUN
admet-2961	345	9	in	in	ADP
admet-2961	345	10	micropatterned	micropatterne	VERB
admet-2961	345	11	cocultures	coculture	NOUN
admet-2961	345	12	.	.	PUNCT
admet-2961	346	1	journal	journal	PROPN
admet-2961	346	2	of	of	ADP
admet-2961	346	3	biochemical	biochemical	ADJ
admet-2961	346	4	and	and	CCONJ
admet-2961	346	5	molecular	molecular	ADJ
admet-2961	346	6	toxicology	toxicology	NOUN
admet-2961	346	7	27	27	NUM
admet-2961	346	8	(	(	PUNCT
admet-2961	346	9	2013	2013	NUM
admet-2961	346	10	)	)	PUNCT
admet-2961	346	11	204	204	NUM
admet-2961	346	12	-	-	SYM
admet-2961	346	13	212	212	NUM
admet-2961	346	14	.	.	PUNCT
admet-2961	347	1	http://doi.org/10.1002/jbt.21469	http://doi.org/10.1002/jbt.21469	X
admet-2961	348	1	[	[	X
admet-2961	348	2	38	38	NUM
admet-2961	348	3	]	]	X
admet-2961	348	4	y.	y.	PROPN
admet-2961	348	5	liu	liu	PROPN
admet-2961	348	6	,	,	PUNCT
admet-2961	348	7	h.	h.	PROPN
admet-2961	348	8	li	li	PROPN
admet-2961	348	9	,	,	PUNCT
admet-2961	348	10	s.	s.	PROPN
admet-2961	348	11	yan	yan	PROPN
admet-2961	348	12	,	,	PUNCT
admet-2961	348	13	j.	j.	PROPN
admet-2961	348	14	wei	wei	PROPN
admet-2961	348	15	,	,	PUNCT
admet-2961	348	16	x.	x.	PROPN
admet-2961	348	17	li	li	PROPN
admet-2961	348	18	.	.	PROPN
admet-2961	348	19	hepatocyte	hepatocyte	PROPN
admet-2961	348	20	cocultures	coculture	VERB
admet-2961	348	21	with	with	ADP
admet-2961	348	22	endothelial	endothelial	ADJ
admet-2961	348	23	cells	cell	NOUN
admet-2961	348	24	and	and	CCONJ
admet-2961	348	25	fibroblasts	fibroblast	NOUN
admet-2961	348	26	on	on	ADP
admet-2961	348	27	micropatterned	micropatterne	VERB
admet-2961	348	28	fibrous	fibrous	ADJ
admet-2961	348	29	mats	mat	NOUN
admet-2961	348	30	to	to	PART
admet-2961	348	31	promote	promote	VERB
admet-2961	348	32	liver	liver	NOUN
admet-2961	348	33	-	-	PUNCT
admet-2961	348	34	specific	specific	ADJ
admet-2961	348	35	functions	function	NOUN
admet-2961	348	36	and	and	CCONJ
admet-2961	348	37	capillary	capillary	ADJ
admet-2961	348	38	formation	formation	NOUN
admet-2961	348	39	capabilities	capability	NOUN
admet-2961	348	40	.	.	PUNCT
admet-2961	349	1	biomacromolecules	biomacromolecule	NOUN
admet-2961	349	2	15	15	NUM
admet-2961	349	3	(	(	PUNCT
admet-2961	349	4	2014	2014	NUM
admet-2961	349	5	)	)	PUNCT
admet-2961	349	6	1044	1044	NUM
admet-2961	349	7	-	-	SYM
admet-2961	349	8	1054	1054	NUM
admet-2961	349	9	.	.	PUNCT
admet-2961	350	1	http://doi.org/10.1021/bm401926k	http://doi.org/10.1021/bm401926k	NOUN
admet-2961	351	1	[	[	X
admet-2961	351	2	39	39	NUM
admet-2961	351	3	]	]	X
admet-2961	351	4	s.r	s.r	PROPN
admet-2961	351	5	.	.	PROPN
admet-2961	351	6	khetani	khetani	PROPN
admet-2961	351	7	,	,	PUNCT
admet-2961	351	8	s.n	s.n	PROPN
admet-2961	351	9	.	.	PROPN
admet-2961	351	10	bhatia	bhatia	PROPN
admet-2961	351	11	.	.	PUNCT
admet-2961	352	1	microscale	microscale	ADJ
admet-2961	352	2	culture	culture	NOUN
admet-2961	352	3	of	of	ADP
admet-2961	352	4	human	human	ADJ
admet-2961	352	5	liver	liver	NOUN
admet-2961	352	6	cells	cell	NOUN
admet-2961	352	7	for	for	ADP
admet-2961	352	8	drug	drug	NOUN
admet-2961	352	9	development	development	NOUN
admet-2961	352	10	.	.	PUNCT
admet-2961	353	1	nature	nature	NOUN
admet-2961	353	2	biotechnology	biotechnology	NOUN
admet-2961	353	3	26	26	NUM
admet-2961	353	4	(	(	PUNCT
admet-2961	353	5	2008	2008	NUM
admet-2961	353	6	)	)	PUNCT
admet-2961	353	7	120	120	NUM
admet-2961	353	8	-	-	SYM
admet-2961	353	9	126	126	NUM
admet-2961	353	10	.	.	PUNCT
admet-2961	354	1	http://doi.org/10.1038/nbt1361	http://doi.org/10.1038/nbt1361	NOUN
admet-2961	355	1	[	[	X
admet-2961	355	2	40	40	NUM
admet-2961	355	3	]	]	PUNCT
admet-2961	355	4	s.	s.	PROPN
admet-2961	355	5	march	march	PROPN
admet-2961	355	6	,	,	PUNCT
admet-2961	355	7	v.	v.	PROPN
admet-2961	355	8	ramanan	ramanan	PROPN
admet-2961	355	9	,	,	PUNCT
admet-2961	355	10	k.	k.	PROPN
admet-2961	355	11	trehan	trehan	PROPN
admet-2961	355	12	,	,	PUNCT
admet-2961	355	13	s.	s.	PROPN
admet-2961	355	14	ng	ng	PROPN
admet-2961	355	15	,	,	PUNCT
admet-2961	355	16	a.	a.	PROPN
admet-2961	355	17	galstian	galstian	PROPN
admet-2961	355	18	,	,	PUNCT
admet-2961	355	19	n.	n.	PROPN
admet-2961	355	20	gural	gural	PROPN
admet-2961	355	21	,	,	PUNCT
admet-2961	355	22	m.a	m.a	PROPN
admet-2961	355	23	.	.	PROPN
admet-2961	355	24	scull	scull	PROPN
admet-2961	355	25	,	,	PUNCT
admet-2961	355	26	a.	a.	NOUN
admet-2961	355	27	shlomai	shlomai	PROPN
admet-2961	355	28	,	,	PUNCT
admet-2961	355	29	m.m	m.m	PROPN
admet-2961	355	30	.	.	PROPN
admet-2961	355	31	mota	mota	PROPN
admet-2961	355	32	,	,	PUNCT
admet-2961	355	33	h.e	h.e	PROPN
admet-2961	355	34	.	.	PROPN
admet-2961	355	35	fleming	fleming	PROPN
admet-2961	355	36	,	,	PUNCT
admet-2961	355	37	s.r	s.r	PROPN
admet-2961	355	38	.	.	PROPN
admet-2961	355	39	khetani	khetani	PROPN
admet-2961	355	40	,	,	PUNCT
admet-2961	355	41	c.m	c.m	PROPN
admet-2961	355	42	.	.	PROPN
admet-2961	355	43	rice	rice	PROPN
admet-2961	355	44	,	,	PUNCT
admet-2961	355	45	s.n	s.n	PROPN
admet-2961	355	46	.	.	PROPN
admet-2961	355	47	bhatia	bhatia	PROPN
admet-2961	355	48	.	.	PUNCT
admet-2961	356	1	micropatterned	micropatterne	VERB
admet-2961	356	2	coculture	coculture	NOUN
admet-2961	356	3	of	of	ADP
admet-2961	356	4	primary	primary	ADJ
admet-2961	356	5	human	human	ADJ
admet-2961	356	6	hepatocytes	hepatocyte	NOUN
admet-2961	356	7	and	and	CCONJ
admet-2961	356	8	supportive	supportive	ADJ
admet-2961	356	9	cells	cell	NOUN
admet-2961	356	10	for	for	ADP
admet-2961	356	11	the	the	DET
admet-2961	356	12	study	study	NOUN
admet-2961	356	13	of	of	ADP
admet-2961	356	14	hepatotropic	hepatotropic	NOUN
admet-2961	356	15	pathogens	pathogen	NOUN
admet-2961	356	16	.	.	PUNCT
admet-2961	357	1	nature	nature	NOUN
admet-2961	357	2	protocols	protocol	NOUN
admet-2961	357	3	10	10	NUM
admet-2961	357	4	(	(	PUNCT
admet-2961	357	5	2015	2015	NUM
admet-2961	357	6	)	)	PUNCT
admet-2961	357	7	2027	2027	NUM
admet-2961	357	8	-	-	SYM
admet-2961	357	9	2053	2053	NUM
admet-2961	357	10	.	.	PUNCT
admet-2961	358	1	http://doi.org/10.1038/nprot.2015.128	http://doi.org/10.1038/nprot.2015.128	NOUN
admet-2961	358	2	[	[	X
admet-2961	358	3	41	41	NUM
admet-2961	358	4	]	]	SYM
admet-2961	358	5	w.w.w	w.w.w	NOUN
admet-2961	358	6	.	.	PUNCT
admet-2961	359	1	wang	wang	PROPN
admet-2961	359	2	,	,	PUNCT
admet-2961	359	3	s.r	s.r	PROPN
admet-2961	359	4	.	.	PROPN
admet-2961	359	5	khetani	khetani	PROPN
admet-2961	359	6	,	,	PUNCT
admet-2961	359	7	s.	s.	PROPN
admet-2961	359	8	krzyzewski	krzyzewski	PROPN
admet-2961	359	9	,	,	PUNCT
admet-2961	359	10	d.b	d.b	PROPN
admet-2961	359	11	.	.	PROPN
admet-2961	359	12	duignan	duignan	PROPN
admet-2961	359	13	,	,	PUNCT
admet-2961	359	14	r.s	r.s	PROPN
admet-2961	359	15	.	.	PROPN
admet-2961	359	16	obach	obach	PROPN
admet-2961	359	17	.	.	PUNCT
admet-2961	360	1	accelerated	accelerate	VERB
admet-2961	360	2	communication	communication	NOUN
admet-2961	360	3	assessment	assessment	NOUN
admet-2961	360	4	of	of	ADP
admet-2961	360	5	a	a	DET
admet-2961	360	6	micropatterned	micropatterne	VERB
admet-2961	360	7	hepatocyte	hepatocyte	NOUN
admet-2961	360	8	coculture	coculture	NOUN
admet-2961	360	9	system	system	NOUN
admet-2961	360	10	to	to	PART
admet-2961	360	11	generate	generate	VERB
admet-2961	360	12	major	major	ADJ
admet-2961	360	13	human	human	ADJ
admet-2961	360	14	excretory	excretory	NOUN
admet-2961	360	15	and	and	CCONJ
admet-2961	360	16	circulating	circulate	VERB
admet-2961	360	17	drug	drug	NOUN
admet-2961	360	18	metabolites	metabolite	NOUN
admet-2961	360	19	.	.	PUNCT
admet-2961	361	1	drug	drug	NOUN
admet-2961	361	2	metabolism	metabolism	NOUN
admet-2961	361	3	and	and	CCONJ
admet-2961	361	4	disposition	disposition	NOUN
admet-2961	361	5	38	38	NUM
admet-2961	361	6	(	(	PUNCT
admet-2961	361	7	2010	2010	NUM
admet-2961	361	8	)	)	PUNCT
admet-2961	361	9	1900	1900	NUM
admet-2961	361	10	-	-	SYM
admet-2961	361	11	1905	1905	NUM
admet-2961	361	12	.	.	PUNCT
admet-2961	362	1	http://doi.org/10.1124/dmd.110.034876	http://doi.org/10.1124/dmd.110.034876	X
admet-2961	362	2	[	[	X
admet-2961	362	3	42	42	NUM
admet-2961	362	4	]	]	X
admet-2961	362	5	j.m	j.m	PROPN
admet-2961	362	6	.	.	PROPN
admet-2961	362	7	hutzler	hutzler	NOUN
admet-2961	362	8	,	,	PUNCT
admet-2961	362	9	b.j	b.j	PROPN
admet-2961	362	10	.	.	PROPN
admet-2961	362	11	ring	ring	PROPN
admet-2961	362	12	,	,	PUNCT
admet-2961	362	13	s.r	s.r	PROPN
admet-2961	362	14	.	.	PROPN
admet-2961	362	15	anderson	anderson	PROPN
admet-2961	362	16	.	.	PUNCT
admet-2961	363	1	low	low	ADJ
admet-2961	363	2	-	-	PUNCT
admet-2961	363	3	turnover	turnover	NOUN
admet-2961	363	4	drug	drug	NOUN
admet-2961	363	5	molecules	molecule	NOUN
admet-2961	363	6	:	:	PUNCT
admet-2961	363	7	a	a	DET
admet-2961	363	8	current	current	ADJ
admet-2961	363	9	challenge	challenge	NOUN
admet-2961	363	10	for	for	ADP
admet-2961	363	11	drug	drug	NOUN
admet-2961	363	12	metabolism	metabolism	NOUN
admet-2961	363	13	scientists	scientist	NOUN
admet-2961	363	14	.	.	PUNCT
admet-2961	364	1	drug	drug	NOUN
admet-2961	364	2	metabolism	metabolism	NOUN
admet-2961	364	3	and	and	CCONJ
admet-2961	364	4	disposition	disposition	NOUN
admet-2961	364	5	43	43	NUM
admet-2961	364	6	(	(	PUNCT
admet-2961	364	7	2015	2015	NUM
admet-2961	364	8	)	)	PUNCT
admet-2961	364	9	1917	1917	NUM
admet-2961	364	10	-	-	SYM
admet-2961	364	11	1928	1928	NUM
admet-2961	364	12	.	.	PUNCT
admet-2961	365	1	http://doi.org/10.1124/dmd.115.066431	http://doi.org/10.1124/dmd.115.066431	NOUN
admet-2961	366	1	[	[	X
admet-2961	366	2	43	43	NUM
admet-2961	366	3	]	]	PUNCT
admet-2961	366	4	p.	p.	PROPN
admet-2961	366	5	chao	chao	PROPN
admet-2961	366	6	,	,	PUNCT
admet-2961	366	7	t.	t.	PROPN
admet-2961	366	8	maguire	maguire	PROPN
admet-2961	366	9	,	,	PUNCT
admet-2961	366	10	e.	e.	PROPN
admet-2961	366	11	novik	novik	PROPN
admet-2961	366	12	,	,	PUNCT
admet-2961	366	13	k.c	k.c	PROPN
admet-2961	366	14	.	.	PROPN
admet-2961	366	15	cheng	cheng	PROPN
admet-2961	366	16	,	,	PUNCT
admet-2961	366	17	m.l	m.l	PROPN
admet-2961	366	18	.	.	PROPN
admet-2961	366	19	yarmush	yarmush	PROPN
admet-2961	366	20	.	.	PUNCT
admet-2961	367	1	evaluation	evaluation	NOUN
admet-2961	367	2	of	of	ADP
admet-2961	367	3	a	a	DET
admet-2961	367	4	microfluidic	microfluidic	ADJ
admet-2961	367	5	based	base	VERB
admet-2961	367	6	cell	cell	NOUN
admet-2961	367	7	culture	culture	NOUN
admet-2961	367	8	platform	platform	NOUN
admet-2961	367	9	with	with	ADP
admet-2961	367	10	primary	primary	ADJ
admet-2961	367	11	human	human	ADJ
admet-2961	367	12	hepatocytes	hepatocyte	NOUN
admet-2961	367	13	for	for	ADP
admet-2961	367	14	the	the	DET
admet-2961	367	15	prediction	prediction	NOUN
admet-2961	367	16	of	of	ADP
admet-2961	367	17	hepatic	hepatic	ADJ
admet-2961	367	18	clearance	clearance	NOUN
admet-2961	367	19	in	in	ADP
admet-2961	367	20	human	human	ADJ
admet-2961	367	21	.	.	PUNCT
admet-2961	368	1	biochemical	biochemical	ADJ
admet-2961	368	2	pharmacology	pharmacology	NOUN
admet-2961	368	3	78	78	NUM
admet-2961	368	4	(	(	PUNCT
admet-2961	368	5	2009	2009	NUM
admet-2961	368	6	)	)	PUNCT
admet-2961	368	7	625	625	NUM
admet-2961	368	8	-	-	SYM
admet-2961	368	9	632	632	NUM
admet-2961	368	10	.	.	PUNCT
admet-2961	369	1	http://doi.org/10.1016/j.bcp.2009.05.013	http://doi.org/10.1016/j.bcp.2009.05.013	PROPN
admet-2961	370	1	[	[	X
admet-2961	370	2	44	44	NUM
admet-2961	370	3	]	]	PUNCT
admet-2961	370	4	e.	e.	PROPN
admet-2961	370	5	novik	novik	PROPN
admet-2961	370	6	,	,	PUNCT
admet-2961	370	7	t.j	t.j	PROPN
admet-2961	370	8	.	.	PROPN
admet-2961	370	9	maguire	maguire	PROPN
admet-2961	370	10	,	,	PUNCT
admet-2961	370	11	p.	p.	PROPN
admet-2961	370	12	chao	chao	PROPN
admet-2961	370	13	,	,	PUNCT
admet-2961	370	14	k.c	k.c	PROPN
admet-2961	370	15	.	.	PROPN
admet-2961	370	16	cheng	cheng	PROPN
admet-2961	370	17	,	,	PUNCT
admet-2961	370	18	m.l	m.l	PROPN
admet-2961	370	19	.	.	PROPN
admet-2961	370	20	yarmush	yarmush	PROPN
admet-2961	370	21	.	.	PUNCT
admet-2961	371	1	a	a	DET
admet-2961	371	2	microfluidic	microfluidic	ADJ
admet-2961	371	3	hepatic	hepatic	ADJ
admet-2961	371	4	coculture	coculture	NOUN
admet-2961	371	5	platform	platform	NOUN
admet-2961	371	6	for	for	ADP
admet-2961	371	7	cell	cell	NOUN
admet-2961	371	8	-	-	PUNCT
admet-2961	371	9	based	base	VERB
admet-2961	371	10	drug	drug	NOUN
admet-2961	371	11	metabolism	metabolism	NOUN
admet-2961	371	12	studies	study	NOUN
admet-2961	371	13	.	.	PUNCT
admet-2961	372	1	biochemical	biochemical	ADJ
admet-2961	372	2	pharmacology	pharmacology	NOUN
admet-2961	372	3	79	79	NUM
admet-2961	372	4	(	(	PUNCT
admet-2961	372	5	2010	2010	NUM
admet-2961	372	6	)	)	PUNCT
admet-2961	372	7	1036	1036	NUM
admet-2961	372	8	-	-	SYM
admet-2961	372	9	1044	1044	NUM
admet-2961	372	10	.	.	PUNCT
admet-2961	373	1	http://doi.org/10.1016/j.bcp.2009.11.010	http://doi.org/10.1016/j.bcp.2009.11.010	PROPN
admet-2961	374	1	[	[	X
admet-2961	374	2	45	45	NUM
admet-2961	374	3	]	]	PUNCT
admet-2961	374	4	i.	i.	NOUN
admet-2961	374	5	hultman	hultman	PROPN
admet-2961	374	6	,	,	PUNCT
admet-2961	374	7	c.	c.	PROPN
admet-2961	374	8	vedin	vedin	PROPN
admet-2961	374	9	,	,	PUNCT
admet-2961	374	10	a.	a.	PROPN
admet-2961	374	11	abrahamsson	abrahamsson	PROPN
admet-2961	374	12	,	,	PUNCT
admet-2961	374	13	s.	s.	PROPN
admet-2961	374	14	winiwarter	winiwarter	PROPN
admet-2961	374	15	,	,	PUNCT
admet-2961	374	16	m.	m.	NOUN
admet-2961	374	17	darnell	darnell	PROPN
admet-2961	374	18	.	.	PUNCT
admet-2961	375	1	use	use	NOUN
admet-2961	375	2	of	of	ADP
admet-2961	375	3	hμrel	hμrel	NOUN
admet-2961	375	4	human	human	PROPN
admet-2961	375	5	coculture	coculture	NOUN
admet-2961	375	6	system	system	NOUN
admet-2961	375	7	for	for	ADP
admet-2961	375	8	prediction	prediction	NOUN
admet-2961	375	9	of	of	ADP
admet-2961	375	10	intrinsic	intrinsic	ADJ
admet-2961	375	11	clearance	clearance	NOUN
admet-2961	375	12	and	and	CCONJ
admet-2961	375	13	metabolite	metabolite	NOUN
admet-2961	375	14	formation	formation	NOUN
admet-2961	375	15	for	for	ADP
admet-2961	375	16	slowly	slowly	ADV
admet-2961	375	17	metabolized	metabolize	VERB
admet-2961	375	18	compounds	compound	NOUN
admet-2961	375	19	.	.	PUNCT
admet-2961	376	1	molecular	molecular	ADJ
admet-2961	376	2	pharmaceutics	pharmaceutic	NOUN
admet-2961	376	3	13	13	NUM
admet-2961	376	4	(	(	PUNCT
admet-2961	376	5	2016	2016	NUM
admet-2961	376	6	)	)	PUNCT
admet-2961	376	7	2796	2796	NUM
admet-2961	376	8	-	-	SYM
admet-2961	376	9	2807	2807	NUM
admet-2961	376	10	.	.	PUNCT
admet-2961	377	1	http://doi.org/10.1021/acs.molpharmaceut.6b00396	http://doi.org/10.1021/acs.molpharmaceut.6b00396	X
admet-2961	377	2	[	[	X
admet-2961	377	3	46	46	NUM
admet-2961	377	4	]	]	PUNCT
admet-2961	377	5	a.	a.	NOUN
admet-2961	377	6	dash	dash	NOUN
admet-2961	377	7	,	,	PUNCT
admet-2961	377	8	w.	w.	PROPN
admet-2961	377	9	inman	inman	PROPN
admet-2961	377	10	,	,	PUNCT
admet-2961	377	11	k.	k.	PROPN
admet-2961	377	12	hoffmaster	hoffmaster	PROPN
admet-2961	377	13	,	,	PUNCT
admet-2961	377	14	s.	s.	PROPN
admet-2961	377	15	sevidal	sevidal	PROPN
admet-2961	377	16	,	,	PUNCT
admet-2961	377	17	j.	j.	PROPN
admet-2961	377	18	kelly	kelly	PROPN
admet-2961	377	19	,	,	PUNCT
admet-2961	377	20	r.s	r.s	PROPN
admet-2961	377	21	.	.	PROPN
admet-2961	377	22	obach	obach	PROPN
admet-2961	377	23	,	,	PUNCT
admet-2961	377	24	l.g	l.g	PROPN
admet-2961	377	25	.	.	PROPN
admet-2961	377	26	griffith	griffith	PROPN
admet-2961	377	27	,	,	PUNCT
admet-2961	377	28	s.r	s.r	PROPN
admet-2961	377	29	.	.	PROPN
admet-2961	377	30	tannenbaum	tannenbaum	PROPN
admet-2961	377	31	.	.	PUNCT
admet-2961	378	1	liver	liver	NOUN
admet-2961	378	2	tissue	tissue	NOUN
admet-2961	378	3	engineering	engineering	NOUN
admet-2961	378	4	in	in	ADP
admet-2961	378	5	the	the	DET
admet-2961	378	6	evaluation	evaluation	NOUN
admet-2961	378	7	of	of	ADP
admet-2961	378	8	drug	drug	NOUN
admet-2961	378	9	safety	safety	NOUN
admet-2961	378	10	.	.	PUNCT
admet-2961	379	1	expert	expert	ADJ
admet-2961	379	2	opinion	opinion	NOUN
admet-2961	379	3	on	on	ADP
admet-2961	379	4	drug	drug	NOUN
admet-2961	379	5	metabolism	metabolism	NOUN
admet-2961	379	6	and	and	CCONJ
admet-2961	379	7	toxicology	toxicology	NOUN
admet-2961	379	8	5	5	NUM
admet-2961	379	9	(	(	PUNCT
admet-2961	379	10	2009	2009	NUM
admet-2961	379	11	)	)	PUNCT
admet-2961	379	12	1159	1159	NUM
admet-2961	379	13	-	-	SYM
admet-2961	379	14	1174	1174	NUM
admet-2961	379	15	.	.	PUNCT
admet-2961	379	16	http://doi.org/10.1517/17425250903160664	http://doi.org/10.1517/17425250903160664	X
admet-2961	380	1	[	[	X
admet-2961	380	2	47	47	NUM
admet-2961	380	3	]	]	PUNCT
admet-2961	380	4	a.	a.	NOUN
admet-2961	380	5	vivares	vivare	NOUN
admet-2961	380	6	,	,	PUNCT
admet-2961	380	7	s.	s.	PROPN
admet-2961	380	8	salle	salle	PROPN
admet-2961	380	9	-	-	PUNCT
admet-2961	380	10	lefort	lefort	ADJ
admet-2961	380	11	,	,	PUNCT
admet-2961	380	12	c.	c.	PROPN
admet-2961	380	13	arabeyre	arabeyre	PROPN
admet-2961	380	14	-	-	PUNCT
admet-2961	380	15	fabre	fabre	PROPN
admet-2961	380	16	,	,	PUNCT
admet-2961	380	17	r.	r.	PROPN
admet-2961	380	18	ngo	ngo	PROPN
admet-2961	380	19	,	,	PUNCT
admet-2961	380	20	g.	g.	PROPN
admet-2961	380	21	penarier	penarier	PROPN
admet-2961	380	22	,	,	PUNCT
admet-2961	380	23	m.	m.	NOUN
admet-2961	380	24	bremond	bremond	NOUN
admet-2961	380	25	,	,	PUNCT
admet-2961	380	26	p.	p.	NOUN
admet-2961	380	27	moliner	moliner	PROPN
admet-2961	380	28	,	,	PUNCT
admet-2961	380	29	j.f	j.f	PROPN
admet-2961	380	30	.	.	PROPN
admet-2961	380	31	gallas	gallas	PROPN
admet-2961	380	32	,	,	PUNCT
admet-2961	380	33	g.	g.	PROPN
admet-2961	380	34	fabre	fabre	PROPN
admet-2961	380	35	,	,	PUNCT
admet-2961	380	36	s.	s.	PROPN
admet-2961	380	37	klieber	klieber	PROPN
admet-2961	380	38	.	.	PUNCT
admet-2961	381	1	morphological	morphological	ADJ
admet-2961	381	2	behaviour	behaviour	NOUN
admet-2961	381	3	and	and	CCONJ
admet-2961	381	4	metabolic	metabolic	NOUN
admet-2961	381	5	capacity	capacity	NOUN
admet-2961	381	6	of	of	ADP
admet-2961	381	7	cryopreserved	cryopreserved	ADJ
admet-2961	381	8	human	human	ADJ
admet-2961	381	9	primary	primary	ADJ
admet-2961	381	10	hepatocytes	hepatocyte	NOUN
admet-2961	381	11	cultivated	cultivate	VERB
admet-2961	381	12	in	in	ADP
admet-2961	381	13	a	a	DET
admet-2961	381	14	perfused	perfuse	VERB
admet-2961	381	15	multiwell	multiwell	ADJ
admet-2961	381	16	device	device	NOUN
admet-2961	381	17	.	.	PUNCT
admet-2961	382	1	xenobiotica	xenobiotica	PROPN
admet-2961	382	2	45	45	NUM
admet-2961	382	3	(	(	PUNCT
admet-2961	382	4	2015	2015	NUM
admet-2961	382	5	)	)	PUNCT
admet-2961	382	6	29	29	NUM
admet-2961	382	7	-	-	SYM
admet-2961	382	8	44	44	NUM
admet-2961	382	9	.	.	PUNCT
admet-2961	382	10	http://doi.org/10.3109/00498254.2014.944612	http://doi.org/10.3109/00498254.2014.944612	PROPN
admet-2961	383	1	[	[	X
admet-2961	383	2	48	48	NUM
admet-2961	383	3	]	]	SYM
admet-2961	383	4	c.m	c.m	PROPN
admet-2961	383	5	.	.	PROPN
admet-2961	383	6	smith	smith	PROPN
admet-2961	383	7	,	,	PUNCT
admet-2961	383	8	c.k	c.k	PROPN
admet-2961	383	9	.	.	PROPN
admet-2961	383	10	nolan	nolan	PROPN
admet-2961	383	11	,	,	PUNCT
admet-2961	383	12	m.a	m.a	PROPN
admet-2961	383	13	.	.	PROPN
admet-2961	383	14	edwards	edwards	PROPN
admet-2961	383	15	,	,	PUNCT
admet-2961	383	16	j.b	j.b	PROPN
admet-2961	383	17	.	.	PROPN
admet-2961	383	18	hatfield	hatfield	PROPN
admet-2961	383	19	,	,	PUNCT
admet-2961	383	20	t.w	t.w	PROPN
admet-2961	383	21	.	.	PROPN
admet-2961	383	22	stewart	stewart	PROPN
admet-2961	383	23	,	,	PUNCT
admet-2961	383	24	s.s	s.s	PROPN
admet-2961	383	25	.	.	PROPN
admet-2961	383	26	ferguson	ferguson	PROPN
admet-2961	383	27	,	,	PUNCT
admet-2961	383	28	e.l	e.l	PROPN
admet-2961	383	29	.	.	PROPN
admet-2961	383	30	lecluyse	lecluyse	PROPN
admet-2961	383	31	,	,	PUNCT
admet-2961	383	32	j.	j.	PROPN
admet-2961	383	33	sahi	sahi	PROPN
admet-2961	383	34	.	.	PUNCT
admet-2961	384	1	a	a	DET
admet-2961	384	2	comprehensive	comprehensive	ADJ
admet-2961	384	3	evaluation	evaluation	NOUN
admet-2961	384	4	of	of	ADP
admet-2961	384	5	metabolic	metabolic	NOUN
admet-2961	384	6	activity	activity	NOUN
admet-2961	384	7	and	and	CCONJ
admet-2961	384	8	intrinsic	intrinsic	ADJ
admet-2961	384	9	clearance	clearance	NOUN
admet-2961	384	10	in	in	ADP
admet-2961	384	11	suspensions	suspension	NOUN
admet-2961	384	12	and	and	CCONJ
admet-2961	384	13	monolayer	monolayer	NOUN
admet-2961	384	14	cultures	culture	NOUN
admet-2961	384	15	of	of	ADP
admet-2961	384	16	cryopreserved	cryopreserved	ADJ
admet-2961	384	17	primary	primary	ADJ
admet-2961	384	18	human	human	ADJ
admet-2961	384	19	hepatocytes	hepatocyte	NOUN
admet-2961	384	20	.	.	PUNCT
admet-2961	385	1	journal	journal	NOUN
admet-2961	385	2	of	of	ADP
admet-2961	385	3	pharmaceutical	pharmaceutical	PROPN
admet-2961	385	4	sciences	science	NOUN
admet-2961	385	5	101(10	101(10	NUM
admet-2961	385	6	)	)	PUNCT
admet-2961	385	7	(	(	PUNCT
admet-2961	385	8	2012	2012	NUM
admet-2961	385	9	)	)	PUNCT
admet-2961	385	10	3989	3989	NUM
admet-2961	385	11	-	-	PUNCT
admet-2961	385	12	4002	4002	NUM
admet-2961	385	13	.	.	PUNCT
admet-2961	386	1	http://doi.org/10.1002/jps.23262	http://doi.org/10.1002/jps.23262	PRON
admet-2961	386	2	[	[	X
admet-2961	386	3	49	49	NUM
admet-2961	386	4	]	]	X
admet-2961	386	5	c.-c	c.-c	NOUN
admet-2961	386	6	.	.	PUNCT
admet-2961	387	1	peng	peng	PROPN
admet-2961	387	2	,	,	PUNCT
admet-2961	387	3	u.	u.	PROPN
admet-2961	387	4	doshi	doshi	PROPN
admet-2961	387	5	,	,	PUNCT
admet-2961	387	6	c.	c.	PROPN
admet-2961	387	7	prakash	prakash	PROPN
admet-2961	387	8	,	,	PUNCT
admet-2961	387	9	a.	a.	PROPN
admet-2961	387	10	li	li	PROPN
admet-2961	387	11	.	.	PUNCT
admet-2961	388	1	a	a	DET
admet-2961	388	2	novel	novel	NOUN
admet-2961	388	3	plated	plate	VERB
admet-2961	388	4	hepatocyte	hepatocyte	NOUN
admet-2961	388	5	relay	relay	NOUN
admet-2961	388	6	assay	assay	PROPN
admet-2961	388	7	(	(	PUNCT
admet-2961	388	8	phra	phra	PROPN
admet-2961	388	9	)	)	PUNCT
admet-2961	388	10	for	for	ADP
admet-2961	388	11	in	in	ADP
admet-2961	388	12	vitro	vitro	X
admet-2961	388	13	evaluation	evaluation	NOUN
admet-2961	388	14	of	of	ADP
admet-2961	388	15	hepatic	hepatic	ADJ
admet-2961	388	16	metabolic	metabolic	NOUN
admet-2961	388	17	clearance	clearance	NOUN
admet-2961	388	18	of	of	ADP
admet-2961	388	19	slowly	slowly	ADV
admet-2961	388	20	metabolized	metabolize	VERB
admet-2961	388	21	compounds	compound	NOUN
admet-2961	388	22	.	.	PUNCT
admet-2961	389	1	drug	drug	NOUN
admet-2961	389	2	metabolism	metabolism	NOUN
admet-2961	389	3	letters	letter	NOUN
admet-2961	389	4	10	10	NUM
admet-2961	389	5	(	(	PUNCT
admet-2961	389	6	2016	2016	NUM
admet-2961	389	7	)	)	PUNCT
admet-2961	389	8	3	3	NUM
admet-2961	389	9	-	-	SYM
admet-2961	389	10	15	15	NUM
admet-2961	389	11	.	.	PUNCT
admet-2961	389	12	http://doi.org/10.2174/1872312809666150818111500	http://doi.org/10.2174/1872312809666150818111500	NOUN
admet-2961	390	1	[	[	X
admet-2961	390	2	50	50	NUM
admet-2961	390	3	]	]	PUNCT
admet-2961	390	4	j.	j.	PROPN
admet-2961	390	5	riede	riede	PROPN
admet-2961	390	6	,	,	PUNCT
admet-2961	390	7	b.m	b.m	PROPN
admet-2961	390	8	.	.	PROPN
admet-2961	390	9	wollmann	wollmann	PROPN
admet-2961	390	10	,	,	PUNCT
admet-2961	390	11	e.	e.	PROPN
admet-2961	390	12	molden	molden	PROPN
admet-2961	390	13	,	,	PUNCT
admet-2961	390	14	m.	m.	NOUN
admet-2961	390	15	ingelman	ingelman	NOUN
admet-2961	390	16	-	-	PUNCT
admet-2961	390	17	sundberg	sundberg	PROPN
admet-2961	390	18	.	.	PUNCT
admet-2961	391	1	primary	primary	ADJ
admet-2961	391	2	human	human	ADJ
admet-2961	391	3	hepatocyte	hepatocyte	NOUN
admet-2961	391	4	spheroids	spheroid	NOUN
admet-2961	391	5	as	as	ADP
admet-2961	391	6	an	an	DET
admet-2961	391	7	in	in	ADP
admet-2961	391	8	vitro	vitro	X
admet-2961	391	9	tool	tool	NOUN
admet-2961	391	10	for	for	ADP
admet-2961	391	11	investigating	investigate	VERB
admet-2961	391	12	drug	drug	NOUN
admet-2961	391	13	compounds	compound	NOUN
admet-2961	391	14	with	with	ADP
admet-2961	391	15	low	low	ADJ
admet-2961	391	16	hepatic	hepatic	ADJ
admet-2961	391	17	clearances	clearance	NOUN
admet-2961	391	18	.	.	PUNCT
admet-2961	392	1	drug	drug	NOUN
admet-2961	392	2	metabolism	metabolism	NOUN
admet-2961	392	3	and	and	CCONJ
admet-2961	392	4	disposition	disposition	NOUN
admet-2961	392	5	49	49	NUM
admet-2961	392	6	(	(	PUNCT
admet-2961	392	7	2021	2021	NUM
admet-2961	392	8	)	)	PUNCT
admet-2961	392	9	501	501	NUM
admet-2961	392	10	-	-	SYM
admet-2961	392	11	508	508	NUM
admet-2961	392	12	.	.	PUNCT
admet-2961	393	1	http://doi.org/10.1124/dmd.120.000340	http://doi.org/10.1124/dmd.120.000340	PROPN
admet-2961	393	2	http://doi.org/10.1016/j.msec.2016.03.025	http://doi.org/10.1016/j.msec.2016.03.025	PROPN
admet-2961	393	3	http://doi.org/10.1002/jbt.21469	http://doi.org/10.1002/jbt.21469	PROPN
admet-2961	393	4	http://doi.org/10.1021/bm401926k	http://doi.org/10.1021/bm401926k	NOUN
admet-2961	393	5	http://doi.org/10.1038/nbt1361	http://doi.org/10.1038/nbt1361	NOUN
admet-2961	393	6	http://doi.org/10.1038/nprot.2015.128	http://doi.org/10.1038/nprot.2015.128	PROPN
admet-2961	393	7	http://doi.org/10.1124/dmd.110.034876	http://doi.org/10.1124/dmd.110.034876	PART
admet-2961	393	8	http://doi.org/10.1124/dmd.115.066431	http://doi.org/10.1124/dmd.115.066431	NOUN
admet-2961	393	9	http://doi.org/10.1016/j.bcp.2009.05.013	http://doi.org/10.1016/j.bcp.2009.05.013	PROPN
admet-2961	393	10	http://doi.org/10.1016/j.bcp.2009.11.010	http://doi.org/10.1016/j.bcp.2009.11.010	PROPN
admet-2961	394	1	http://doi.org/10.1021/acs.molpharmaceut.6b00396	http://doi.org/10.1021/acs.molpharmaceut.6b00396	ADV
admet-2961	394	2	http://doi.org/10.1517/17425250903160664	http://doi.org/10.1517/17425250903160664	VERB
admet-2961	394	3	http://doi.org/10.3109/00498254.2014.944612	http://doi.org/10.3109/00498254.2014.944612	PROPN
admet-2961	394	4	http://doi.org/10.1002/jps.23262	http://doi.org/10.1002/jps.23262	PROPN
admet-2961	394	5	http://doi.org/10.2174/1872312809666150818111500	http://doi.org/10.2174/1872312809666150818111500	PROPN
admet-2961	394	6	http://doi.org/10.1124/dmd.120.000340	http://doi.org/10.1124/dmd.120.000340	PROPN
admet-2961	394	7	admet	admet	PROPN
admet-2961	394	8	&	&	CCONJ
admet-2961	394	9	dmpk	dmpk	PROPN
admet-2961	394	10	16(5	16(5	NUM
admet-2961	394	11	)	)	PUNCT
admet-2961	394	12	(	(	PUNCT
admet-2961	394	13	2025	2025	NUM
admet-2961	394	14	)	)	PUNCT
admet-2961	394	15	2961	2961	NUM
admet-2961	394	16	natural	natural	ADJ
admet-2961	394	17	molecules	molecule	NOUN
admet-2961	394	18	for	for	ADP
admet-2961	394	19	emt	emt	PROPN
admet-2961	394	20	treatment	treatment	NOUN
admet-2961	394	21	doi	doi	NOUN
admet-2961	394	22	:	:	PUNCT
admet-2961	394	23	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	X
admet-2961	394	24	15	15	NUM
admet-2961	394	25	[	[	SYM
admet-2961	394	26	51	51	NUM
admet-2961	394	27	]	]	PUNCT
admet-2961	394	28	e.	e.	PROPN
admet-2961	394	29	alexandre	alexandre	PROPN
admet-2961	394	30	,	,	PUNCT
admet-2961	394	31	a.	a.	NOUN
admet-2961	394	32	baze	baze	PROPN
admet-2961	394	33	,	,	PUNCT
admet-2961	394	34	c.	c.	PROPN
admet-2961	394	35	parmentier	parmentier	PROPN
admet-2961	394	36	,	,	PUNCT
admet-2961	394	37	c.	c.	PROPN
admet-2961	394	38	desbans	desbans	PROPN
admet-2961	394	39	,	,	PUNCT
admet-2961	394	40	d.	d.	PROPN
admet-2961	394	41	pekthong	pekthong	PROPN
admet-2961	394	42	,	,	PUNCT
admet-2961	394	43	b.	b.	PROPN
admet-2961	394	44	gerin	gerin	NOUN
admet-2961	394	45	,	,	PUNCT
admet-2961	394	46	c.	c.	PROPN
admet-2961	394	47	wack	wack	NOUN
admet-2961	394	48	,	,	PUNCT
admet-2961	394	49	p.	p.	NOUN
admet-2961	394	50	bachellier	bachellier	NOUN
admet-2961	394	51	,	,	PUNCT
admet-2961	394	52	b.	b.	PROPN
admet-2961	394	53	heyd	heyd	PROPN
admet-2961	394	54	,	,	PUNCT
admet-2961	394	55	j.c	j.c	PROPN
admet-2961	394	56	.	.	PROPN
admet-2961	394	57	weber	weber	PROPN
admet-2961	394	58	,	,	PUNCT
admet-2961	394	59	l.	l.	PROPN
admet-2961	394	60	richert	richert	PROPN
admet-2961	394	61	.	.	PROPN
admet-2961	395	1	plateable	plateable	PROPN
admet-2961	395	2	cryopreserved	cryopreserve	VERB
admet-2961	395	3	human	human	ADJ
admet-2961	395	4	hepatocytes	hepatocyte	NOUN
admet-2961	395	5	for	for	ADP
admet-2961	395	6	the	the	DET
admet-2961	395	7	assessment	assessment	NOUN
admet-2961	395	8	of	of	ADP
admet-2961	395	9	cytochrome	cytochrome	ADJ
admet-2961	395	10	p450	p450	PROPN
admet-2961	395	11	inducibility	inducibility	NOUN
admet-2961	395	12	:	:	PUNCT
admet-2961	395	13	experimental	experimental	ADJ
admet-2961	395	14	condition	condition	NOUN
admet-2961	395	15	-	-	PUNCT
admet-2961	395	16	related	relate	VERB
admet-2961	395	17	variables	variable	NOUN
admet-2961	395	18	affecting	affect	VERB
admet-2961	395	19	their	their	PRON
admet-2961	395	20	response	response	NOUN
admet-2961	395	21	to	to	ADP
admet-2961	395	22	inducers	inducer	NOUN
admet-2961	395	23	.	.	PUNCT
admet-2961	396	1	xenobiotica	xenobiotica	PROPN
admet-2961	396	2	42	42	NUM
admet-2961	396	3	(	(	PUNCT
admet-2961	396	4	2012	2012	NUM
admet-2961	396	5	)	)	PUNCT
admet-2961	396	6	968	968	NUM
admet-2961	396	7	-	-	SYM
admet-2961	396	8	979	979	NUM
admet-2961	396	9	.	.	PUNCT
admet-2961	396	10	http://doi.org/10.3109/00498254.2012.676693	http://doi.org/10.3109/00498254.2012.676693	X
admet-2961	397	1	[	[	X
admet-2961	397	2	52	52	NUM
admet-2961	397	3	]	]	PUNCT
admet-2961	397	4	m.	m.	NOUN
admet-2961	397	5	darnell	darnell	PROPN
admet-2961	397	6	,	,	PUNCT
admet-2961	397	7	m.	m.	NOUN
admet-2961	397	8	ulvestad	ulvestad	PROPN
admet-2961	397	9	,	,	PUNCT
admet-2961	397	10	e.	e.	PROPN
admet-2961	397	11	ellis	ellis	PROPN
admet-2961	397	12	,	,	PUNCT
admet-2961	397	13	l.	l.	PROPN
admet-2961	397	14	weidolf	weidolf	PROPN
admet-2961	397	15	,	,	PUNCT
admet-2961	397	16	t.b	t.b	PROPN
admet-2961	397	17	.	.	PROPN
admet-2961	397	18	andersson	andersson	PROPN
admet-2961	397	19	.	.	PUNCT
admet-2961	398	1	in	in	ADP
admet-2961	398	2	vitro	vitro	X
admet-2961	398	3	evaluation	evaluation	NOUN
admet-2961	398	4	of	of	ADP
admet-2961	398	5	major	major	NOUN
admet-2961	398	6	in	in	ADP
admet-2961	398	7	vivo	vivo	ADJ
admet-2961	398	8	drug	drug	NOUN
admet-2961	398	9	metabolic	metabolic	NOUN
admet-2961	398	10	pathways	pathway	NOUN
admet-2961	398	11	using	use	VERB
admet-2961	398	12	primary	primary	ADJ
admet-2961	398	13	human	human	ADJ
admet-2961	398	14	hepatocytes	hepatocyte	NOUN
admet-2961	398	15	and	and	CCONJ
admet-2961	398	16	heparg	heparg	NOUN
admet-2961	398	17	cells	cell	NOUN
admet-2961	398	18	in	in	ADP
admet-2961	398	19	suspension	suspension	NOUN
admet-2961	398	20	and	and	CCONJ
admet-2961	398	21	a	a	DET
admet-2961	398	22	dynamic	dynamic	ADJ
admet-2961	398	23	three	three	NUM
admet-2961	398	24	-	-	PUNCT
admet-2961	398	25	dimensional	dimensional	ADJ
admet-2961	398	26	bioreactor	bioreactor	NOUN
admet-2961	398	27	system	system	NOUN
admet-2961	398	28	.	.	PUNCT
admet-2961	399	1	journal	journal	PROPN
admet-2961	399	2	of	of	ADP
admet-2961	399	3	pharmacology	pharmacology	NOUN
admet-2961	399	4	and	and	CCONJ
admet-2961	399	5	experimental	experimental	ADJ
admet-2961	399	6	therapeutics	therapeutic	NOUN
admet-2961	399	7	343	343	NUM
admet-2961	399	8	(	(	PUNCT
admet-2961	399	9	2012	2012	NUM
admet-2961	399	10	)	)	PUNCT
admet-2961	399	11	134	134	NUM
admet-2961	399	12	-	-	SYM
admet-2961	399	13	144	144	NUM
admet-2961	399	14	.	.	PUNCT
admet-2961	400	1	http://doi.org/10.1124/jpet.112.195834	http://doi.org/10.1124/jpet.112.195834	NOUN
admet-2961	400	2	[	[	X
admet-2961	400	3	53	53	NUM
admet-2961	400	4	]	]	X
admet-2961	400	5	s.j	s.j	PROPN
admet-2961	400	6	.	.	PROPN
admet-2961	400	7	griffin	griffin	PROPN
admet-2961	400	8	,	,	PUNCT
admet-2961	400	9	j.b	j.b	PROPN
admet-2961	400	10	.	.	PROPN
admet-2961	400	11	houston	houston	PROPN
admet-2961	400	12	.	.	PUNCT
admet-2961	401	1	prediction	prediction	NOUN
admet-2961	401	2	of	of	ADP
admet-2961	401	3	in	in	ADP
admet-2961	401	4	vitro	vitro	X
admet-2961	401	5	intrinsic	intrinsic	ADJ
admet-2961	401	6	clearance	clearance	NOUN
admet-2961	401	7	from	from	ADP
admet-2961	401	8	hepatocytes	hepatocyte	NOUN
admet-2961	401	9	:	:	PUNCT
admet-2961	401	10	comparison	comparison	NOUN
admet-2961	401	11	of	of	ADP
admet-2961	401	12	suspensions	suspension	NOUN
admet-2961	401	13	and	and	CCONJ
admet-2961	401	14	monolayer	monolayer	NOUN
admet-2961	401	15	cultures	culture	NOUN
admet-2961	401	16	.	.	PUNCT
admet-2961	402	1	drug	drug	NOUN
admet-2961	402	2	metabolism	metabolism	NOUN
admet-2961	402	3	and	and	CCONJ
admet-2961	402	4	disposition	disposition	NOUN
admet-2961	402	5	33	33	NUM
admet-2961	402	6	(	(	PUNCT
admet-2961	402	7	2005	2005	NUM
admet-2961	402	8	)	)	PUNCT
admet-2961	402	9	115	115	NUM
admet-2961	402	10	-	-	SYM
admet-2961	402	11	120	120	NUM
admet-2961	402	12	.	.	PUNCT
admet-2961	403	1	http://doi.org/10.1124/dmd.33.1.115	http://doi.org/10.1124/dmd.33.1.115	PROPN
admet-2961	403	2	[	[	X
admet-2961	403	3	54	54	NUM
admet-2961	403	4	]	]	X
admet-2961	403	5	n.	n.	PROPN
admet-2961	403	6	blanchard	blanchard	PROPN
admet-2961	403	7	,	,	PUNCT
admet-2961	403	8	e.	e.	PROPN
admet-2961	403	9	alexandre	alexandre	PROPN
admet-2961	403	10	,	,	PUNCT
admet-2961	403	11	c.	c.	PROPN
admet-2961	403	12	abadie	abadie	PROPN
admet-2961	403	13	,	,	PUNCT
admet-2961	403	14	t.	t.	PROPN
admet-2961	403	15	lavé	lavé	PROPN
admet-2961	403	16	,	,	PUNCT
admet-2961	403	17	b.	b.	PROPN
admet-2961	403	18	heyd	heyd	PROPN
admet-2961	403	19	,	,	PUNCT
admet-2961	403	20	g.	g.	PROPN
admet-2961	403	21	mantion	mantion	PROPN
admet-2961	403	22	,	,	PUNCT
admet-2961	403	23	d.	d.	PROPN
admet-2961	403	24	jaeck	jaeck	PROPN
admet-2961	403	25	,	,	PUNCT
admet-2961	403	26	l.	l.	PROPN
admet-2961	403	27	richert	richert	PROPN
admet-2961	403	28	,	,	PUNCT
admet-2961	403	29	p.	p.	NOUN
admet-2961	403	30	coassolo	coassolo	PROPN
admet-2961	403	31	.	.	PUNCT
admet-2961	404	1	comparison	comparison	NOUN
admet-2961	404	2	of	of	ADP
admet-2961	404	3	clearance	clearance	NOUN
admet-2961	404	4	predictions	prediction	NOUN
admet-2961	404	5	using	use	VERB
admet-2961	404	6	primary	primary	ADJ
admet-2961	404	7	cultures	culture	NOUN
admet-2961	404	8	and	and	CCONJ
admet-2961	404	9	suspensions	suspension	NOUN
admet-2961	404	10	of	of	ADP
admet-2961	404	11	human	human	ADJ
admet-2961	404	12	hepatocytes	hepatocyte	NOUN
admet-2961	404	13	.	.	PUNCT
admet-2961	405	1	xenobiotica	xenobiotica	PROPN
admet-2961	405	2	35	35	NUM
admet-2961	405	3	(	(	PUNCT
admet-2961	405	4	2005	2005	NUM
admet-2961	405	5	)	)	PUNCT
admet-2961	405	6	1	1	NUM
admet-2961	405	7	-	-	SYM
admet-2961	405	8	15	15	NUM
admet-2961	405	9	.	.	PUNCT
admet-2961	405	10	http://doi.org/10.1080/00498250400021820	http://doi.org/10.1080/00498250400021820	NOUN
admet-2961	406	1	[	[	X
admet-2961	406	2	55	55	NUM
admet-2961	406	3	]	]	X
admet-2961	406	4	ema	ema	PROPN
admet-2961	406	5	.	.	PUNCT
admet-2961	407	1	guideline	guideline	NOUN
admet-2961	407	2	on	on	ADP
admet-2961	407	3	the	the	DET
admet-2961	407	4	investigation	investigation	NOUN
admet-2961	407	5	of	of	ADP
admet-2961	407	6	drug	drug	NOUN
admet-2961	407	7	interactions	interaction	NOUN
admet-2961	407	8	.	.	PUNCT
admet-2961	408	1	european	european	ADJ
admet-2961	408	2	medicine	medicine	PROPN
admet-2961	408	3	agency	agency	PROPN
admet-2961	408	4	44	44	NUM
admet-2961	408	5	(	(	PUNCT
admet-2961	408	6	2012	2012	NUM
admet-2961	408	7	)	)	PUNCT
admet-2961	408	8	1	1	NUM
admet-2961	408	9	-	-	SYM
admet-2961	408	10	59	59	NUM
admet-2961	408	11	.	.	PUNCT
admet-2961	408	12	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-druginteractions-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-druginteractions-revision-1_en.pdf	NOUN
admet-2961	409	1	[	[	X
admet-2961	409	2	56	56	NUM
admet-2961	409	3	]	]	X
admet-2961	409	4	c.d	c.d	PROPN
admet-2961	409	5	.	.	PROPN
admet-2961	409	6	thomas	thomas	PROPN
admet-2961	409	7	,	,	PUNCT
admet-2961	409	8	s.a	s.a	PROPN
admet-2961	409	9	.	.	PROPN
admet-2961	409	10	mosley	mosley	PROPN
admet-2961	409	11	,	,	PUNCT
admet-2961	409	12	s.	s.	PROPN
admet-2961	409	13	kim	kim	PROPN
admet-2961	409	14	,	,	PUNCT
admet-2961	409	15	k.	k.	PROPN
admet-2961	409	16	lingineni	lingineni	PROPN
admet-2961	409	17	,	,	PUNCT
admet-2961	409	18	n.	n.	PROPN
admet-2961	409	19	el	el	PROPN
admet-2961	409	20	rouby	rouby	PROPN
admet-2961	409	21	,	,	PUNCT
admet-2961	409	22	t.y	t.y	PROPN
admet-2961	409	23	.	.	PROPN
admet-2961	409	24	langaee	langaee	PROPN
admet-2961	409	25	,	,	PUNCT
admet-2961	409	26	y.	y.	PROPN
admet-2961	409	27	gong	gong	PROPN
admet-2961	409	28	,	,	PUNCT
admet-2961	409	29	d.	d.	PROPN
admet-2961	409	30	wang	wang	PROPN
admet-2961	409	31	,	,	PUNCT
admet-2961	409	32	s.o	s.o	PROPN
admet-2961	409	33	.	.	PROPN
admet-2961	409	34	schmidt	schmidt	PROPN
admet-2961	409	35	,	,	PUNCT
admet-2961	409	36	p.f	p.f	PROPN
admet-2961	409	37	.	.	PROPN
admet-2961	409	38	binkley	binkley	PROPN
admet-2961	409	39	,	,	PUNCT
admet-2961	409	40	d.s	d.s	PROPN
admet-2961	409	41	.	.	PROPN
admet-2961	409	42	estores	estores	PROPN
admet-2961	409	43	,	,	PUNCT
admet-2961	409	44	k.	k.	PROPN
admet-2961	409	45	feng	feng	PROPN
admet-2961	409	46	,	,	PUNCT
admet-2961	409	47	h.	h.	PROPN
admet-2961	409	48	kim	kim	PROPN
admet-2961	409	49	,	,	PUNCT
admet-2961	409	50	m.	m.	NOUN
admet-2961	409	51	kinjo	kinjo	PROPN
admet-2961	409	52	,	,	PUNCT
admet-2961	409	53	z.	z.	PROPN
admet-2961	409	54	li	li	PROPN
admet-2961	409	55	,	,	PUNCT
admet-2961	409	56	l.	l.	PROPN
admet-2961	409	57	fang	fang	PROPN
admet-2961	409	58	,	,	PUNCT
admet-2961	409	59	a.b	a.b	PROPN
admet-2961	409	60	.	.	PROPN
admet-2961	409	61	chapman	chapman	PROPN
admet-2961	409	62	,	,	PUNCT
admet-2961	409	63	r.m	r.m	PROPN
admet-2961	409	64	.	.	PROPN
admet-2961	409	65	cooperdehoff	cooperdehoff	PROPN
admet-2961	409	66	,	,	PUNCT
admet-2961	409	67	j.g	j.g	PROPN
admet-2961	409	68	.	.	PROPN
admet-2961	409	69	gums	gum	NOUN
admet-2961	409	70	,	,	PUNCT
admet-2961	409	71	i.s	i.s	PROPN
admet-2961	409	72	.	.	PUNCT
admet-2961	409	73	hamadeh	hamadeh	PROPN
admet-2961	409	74	,	,	PUNCT
admet-2961	409	75	l.	l.	PROPN
admet-2961	409	76	zhao	zhao	PROPN
admet-2961	409	77	,	,	PUNCT
admet-2961	409	78	s.	s.	PROPN
admet-2961	409	79	schmidt	schmidt	PROPN
admet-2961	409	80	,	,	PUNCT
admet-2961	409	81	r.f	r.f	PROPN
admet-2961	409	82	.	.	PROPN
admet-2961	409	83	frye	frye	PROPN
admet-2961	409	84	,	,	PUNCT
admet-2961	409	85	j.a	j.a	PROPN
admet-2961	409	86	.	.	PROPN
admet-2961	409	87	johnson	johnson	PROPN
admet-2961	409	88	,	,	PUNCT
admet-2961	409	89	l.h	l.h	PROPN
admet-2961	409	90	.	.	PROPN
admet-2961	409	91	cavallari	cavallari	PROPN
admet-2961	409	92	.	.	PUNCT
admet-2961	410	1	examination	examination	NOUN
admet-2961	410	2	of	of	ADP
admet-2961	410	3	metoprolol	metoprolol	NOUN
admet-2961	410	4	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	410	5	and	and	CCONJ
admet-2961	410	6	pharmacodynamics	pharmacodynamic	NOUN
admet-2961	410	7	across	across	ADP
admet-2961	410	8	cyp2d6	cyp2d6	NOUN
admet-2961	410	9	genotypederived	genotypederive	VERB
admet-2961	410	10	activity	activity	NOUN
admet-2961	410	11	scores	score	NOUN
admet-2961	410	12	.	.	PUNCT
admet-2961	411	1	cpt	cpt	NOUN
admet-2961	411	2	:	:	PUNCT
admet-2961	411	3	pharmacometrics	pharmacometric	NOUN
admet-2961	411	4	and	and	CCONJ
admet-2961	411	5	systems	system	NOUN
admet-2961	411	6	pharmacology	pharmacology	NOUN
admet-2961	411	7	9	9	NUM
admet-2961	411	8	(	(	PUNCT
admet-2961	411	9	2020	2020	NUM
admet-2961	411	10	)	)	PUNCT
admet-2961	411	11	678	678	NUM
admet-2961	411	12	-	-	SYM
admet-2961	411	13	685	685	NUM
admet-2961	411	14	.	.	PUNCT
admet-2961	411	15	http://doi.org/10.1002/psp4.12563	http://doi.org/10.1002/psp4.12563	PUNCT
admet-2961	412	1	[	[	X
admet-2961	412	2	57	57	NUM
admet-2961	412	3	]	]	X
admet-2961	412	4	v.b	v.b	PROPN
admet-2961	412	5	.	.	PROPN
admet-2961	412	6	boralli	boralli	PROPN
admet-2961	412	7	,	,	PUNCT
admet-2961	412	8	e.b	e.b	PROPN
admet-2961	412	9	.	.	PROPN
admet-2961	412	10	coelho	coelho	PROPN
admet-2961	412	11	,	,	PUNCT
admet-2961	412	12	p.m.	p.m.	PROPN
admet-2961	412	13	cerqueira	cerqueira	PROPN
admet-2961	412	14	,	,	PUNCT
admet-2961	412	15	v.l	v.l	PROPN
admet-2961	412	16	.	.	PROPN
admet-2961	412	17	lanchote	lanchote	NOUN
admet-2961	412	18	.	.	PUNCT
admet-2961	413	1	stereoselective	stereoselective	ADJ
admet-2961	413	2	analysis	analysis	NOUN
admet-2961	413	3	of	of	ADP
admet-2961	413	4	metoprolol	metoprolol	NOUN
admet-2961	413	5	and	and	CCONJ
admet-2961	413	6	its	its	PRON
admet-2961	413	7	metabolites	metabolite	NOUN
admet-2961	413	8	in	in	ADP
admet-2961	413	9	rat	rat	NOUN
admet-2961	413	10	plasma	plasma	NOUN
admet-2961	413	11	with	with	ADP
admet-2961	413	12	application	application	NOUN
admet-2961	413	13	to	to	PART
admet-2961	413	14	oxidative	oxidative	ADJ
admet-2961	413	15	metabolism	metabolism	NOUN
admet-2961	413	16	.	.	PUNCT
admet-2961	414	1	journal	journal	NOUN
admet-2961	414	2	of	of	ADP
admet-2961	414	3	chromatography	chromatography	NOUN
admet-2961	414	4	b	b	PROPN
admet-2961	414	5	:	:	PUNCT
admet-2961	414	6	analytical	analytical	ADJ
admet-2961	414	7	technologies	technology	NOUN
admet-2961	414	8	in	in	ADP
admet-2961	414	9	the	the	DET
admet-2961	414	10	biomedical	biomedical	ADJ
admet-2961	414	11	and	and	CCONJ
admet-2961	414	12	life	life	NOUN
admet-2961	414	13	sciences	science	NOUN
admet-2961	414	14	823	823	NUM
admet-2961	414	15	(	(	PUNCT
admet-2961	414	16	2005	2005	NUM
admet-2961	414	17	)	)	PUNCT
admet-2961	414	18	195	195	NUM
admet-2961	414	19	-	-	SYM
admet-2961	414	20	202	202	NUM
admet-2961	414	21	.	.	PUNCT
admet-2961	415	1	http://doi.org/10.1016/j.jchromb.2005.06.038	http://doi.org/10.1016/j.jchromb.2005.06.038	PROPN
admet-2961	415	2	[	[	X
admet-2961	415	3	58	58	NUM
admet-2961	415	4	]	]	PUNCT
admet-2961	415	5	laura	laura	PROPN
admet-2961	415	6	dean	dean	PROPN
admet-2961	415	7	,	,	PUNCT
admet-2961	415	8	victoria	victoria	PROPN
admet-2961	415	9	m.	m.	PROPN
admet-2961	415	10	pratt	pratt	PROPN
admet-2961	415	11	,	,	PUNCT
admet-2961	415	12	stuart	stuart	PROPN
admet-2961	415	13	a.	a.	PROPN
admet-2961	415	14	scott	scott	PROPN
admet-2961	415	15	,	,	PUNCT
admet-2961	415	16	munir	munir	PROPN
admet-2961	415	17	pirmohamed	pirmohamed	PROPN
admet-2961	415	18	,	,	PUNCT
admet-2961	415	19	bernard	bernard	PROPN
admet-2961	415	20	esquivel	esquivel	PROPN
admet-2961	415	21	,	,	PUNCT
admet-2961	415	22	brandi	brandi	PROPN
admet-2961	415	23	l.	l.	PROPN
admet-2961	415	24	kattman	kattman	PROPN
admet-2961	415	25	,	,	PUNCT
admet-2961	415	26	adriana	adriana	PROPN
admet-2961	415	27	j.	j.	PROPN
admet-2961	415	28	malheiro	malheiro	PROPN
admet-2961	415	29	.	.	PUNCT
admet-2961	416	1	metoprolol	metoprolol	PROPN
admet-2961	416	2	therapy	therapy	NOUN
admet-2961	416	3	and	and	CCONJ
admet-2961	416	4	cyp2d6	cyp2d6	NOUN
admet-2961	416	5	genotype	genotype	PROPN
admet-2961	416	6	,	,	PUNCT
admet-2961	416	7	medical	medical	ADJ
admet-2961	416	8	genetics	genetic	NOUN
admet-2961	416	9	summaries	summary	NOUN
admet-2961	416	10	,	,	PUNCT
admet-2961	416	11	bethesda	bethesda	PROPN
admet-2961	416	12	(	(	PUNCT
admet-2961	416	13	md	md	PROPN
admet-2961	416	14	):	):	PUNCT
admet-2961	416	15	national	national	ADJ
admet-2961	416	16	center	center	NOUN
admet-2961	416	17	for	for	ADP
admet-2961	416	18	biotechnology	biotechnology	NOUN
admet-2961	416	19	information	information	NOUN
admet-2961	416	20	,	,	PUNCT
admet-2961	416	21	us	we	PRON
admet-2961	416	22	,	,	PUNCT
admet-2961	416	23	2012	2012	NUM
admet-2961	416	24	.	.	PUNCT
admet-2961	417	1	https://pubmed.ncbi.nlm.nih.gov/28520381/	https://pubmed.ncbi.nlm.nih.gov/28520381/	PROPN
admet-2961	417	2	[	[	X
admet-2961	417	3	59	59	NUM
admet-2961	417	4	]	]	PUNCT
admet-2961	417	5	s.-m	s.-m	PROPN
admet-2961	417	6	.	.	PUNCT
admet-2961	418	1	huang	huang	PROPN
admet-2961	418	2	,	,	PUNCT
admet-2961	418	3	r.	r.	PROPN
admet-2961	418	4	temple	temple	PROPN
admet-2961	418	5	,	,	PUNCT
admet-2961	418	6	d.c	d.c	PROPN
admet-2961	418	7	.	.	PROPN
admet-2961	418	8	throckmorton	throckmorton	PROPN
admet-2961	418	9	,	,	PUNCT
admet-2961	418	10	l.j	l.j	PROPN
admet-2961	418	11	.	.	PROPN
admet-2961	418	12	lesko	lesko	PROPN
admet-2961	418	13	.	.	PUNCT
admet-2961	419	1	drug	drug	NOUN
admet-2961	419	2	interaction	interaction	NOUN
admet-2961	419	3	studies	study	NOUN
admet-2961	419	4	:	:	PUNCT
admet-2961	419	5	study	study	NOUN
admet-2961	419	6	design	design	NOUN
admet-2961	419	7	,	,	PUNCT
admet-2961	419	8	data	datum	NOUN
admet-2961	419	9	analysis	analysis	NOUN
admet-2961	419	10	,	,	PUNCT
admet-2961	419	11	and	and	CCONJ
admet-2961	419	12	implications	implication	NOUN
admet-2961	419	13	for	for	ADP
admet-2961	419	14	dosing	dosing	NOUN
admet-2961	419	15	and	and	CCONJ
admet-2961	419	16	labeling	labeling	NOUN
admet-2961	419	17	.	.	PUNCT
admet-2961	420	1	clinical	clinical	ADJ
admet-2961	420	2	pharmacology	pharmacology	NOUN
admet-2961	420	3	and	and	CCONJ
admet-2961	420	4	therapeutics	therapeutic	NOUN
admet-2961	420	5	81	81	NUM
admet-2961	420	6	(	(	PUNCT
admet-2961	420	7	2007	2007	NUM
admet-2961	420	8	)	)	PUNCT
admet-2961	420	9	298	298	NUM
admet-2961	420	10	-	-	SYM
admet-2961	420	11	304	304	NUM
admet-2961	420	12	.	.	PUNCT
admet-2961	421	1	http://doi.org/10.1038/sj.clpt.6100054	http://doi.org/10.1038/sj.clpt.6100054	PROPN
admet-2961	422	1	[	[	X
admet-2961	422	2	60	60	NUM
admet-2961	422	3	]	]	X
admet-2961	422	4	d.f	d.f	PROPN
admet-2961	422	5	.	.	PROPN
admet-2961	422	6	mcginnity	mcginnity	PROPN
admet-2961	422	7	,	,	PUNCT
admet-2961	422	8	a.j	a.j	PROPN
admet-2961	422	9	.	.	PROPN
admet-2961	422	10	parker	parker	PROPN
admet-2961	422	11	,	,	PUNCT
admet-2961	422	12	m.	m.	NOUN
admet-2961	422	13	soars	soar	NOUN
admet-2961	422	14	,	,	PUNCT
admet-2961	422	15	r.j	r.j	PROPN
admet-2961	422	16	.	.	PROPN
admet-2961	422	17	riley	riley	PROPN
admet-2961	422	18	.	.	PUNCT
admet-2961	423	1	automated	automate	VERB
admet-2961	423	2	definition	definition	NOUN
admet-2961	423	3	of	of	ADP
admet-2961	423	4	the	the	DET
admet-2961	423	5	enzymology	enzymology	NOUN
admet-2961	423	6	of	of	ADP
admet-2961	423	7	drug	drug	NOUN
admet-2961	423	8	oxidation	oxidation	NOUN
admet-2961	423	9	by	by	ADP
admet-2961	423	10	the	the	DET
admet-2961	423	11	major	major	ADJ
admet-2961	423	12	human	human	ADJ
admet-2961	423	13	drug	drug	NOUN
admet-2961	423	14	metabolizing	metabolize	VERB
admet-2961	423	15	cytochrome	cytochrome	NOUN
admet-2961	423	16	p450s	p450s	PROPN
admet-2961	423	17	.	.	PUNCT
admet-2961	424	1	drug	drug	NOUN
admet-2961	424	2	metabolism	metabolism	NOUN
admet-2961	424	3	and	and	CCONJ
admet-2961	424	4	disposition	disposition	NOUN
admet-2961	424	5	28	28	NUM
admet-2961	424	6	(	(	PUNCT
admet-2961	424	7	2000	2000	NUM
admet-2961	424	8	)	)	PUNCT
admet-2961	424	9	1327	1327	NUM
admet-2961	424	10	-	-	SYM
admet-2961	424	11	1334	1334	NUM
admet-2961	424	12	.	.	PUNCT
admet-2961	425	1	https://doi.org/10.1016/s0090-9556(24)15081-7	https://doi.org/10.1016/s0090-9556(24)15081-7	PROPN
admet-2961	426	1	[	[	X
admet-2961	426	2	61	61	NUM
admet-2961	426	3	]	]	PUNCT
admet-2961	426	4	t.	t.	PROPN
admet-2961	426	5	yamamoto	yamamoto	PROPN
admet-2961	426	6	,	,	PUNCT
admet-2961	426	7	h.	h.	PROPN
admet-2961	426	8	itoga	itoga	PROPN
admet-2961	426	9	,	,	PUNCT
admet-2961	426	10	y.	y.	PROPN
admet-2961	426	11	kohno	kohno	PROPN
admet-2961	426	12	,	,	PUNCT
admet-2961	426	13	k.	k.	PROPN
admet-2961	426	14	nagata	nagata	PROPN
admet-2961	426	15	,	,	PUNCT
admet-2961	426	16	y.	y.	PROPN
admet-2961	426	17	yamazoe	yamazoe	PROPN
admet-2961	426	18	.	.	PUNCT
admet-2961	427	1	prediction	prediction	NOUN
admet-2961	427	2	of	of	ADP
admet-2961	427	3	oral	oral	ADJ
admet-2961	427	4	clearance	clearance	NOUN
admet-2961	427	5	from	from	ADP
admet-2961	427	6	in	in	ADP
admet-2961	427	7	vitro	vitro	X
admet-2961	427	8	metabolic	metabolic	NOUN
admet-2961	427	9	data	datum	NOUN
admet-2961	427	10	using	use	VERB
admet-2961	427	11	recombinant	recombinant	ADJ
admet-2961	427	12	cyps	cyp	NOUN
admet-2961	427	13	:	:	PUNCT
admet-2961	427	14	comparison	comparison	NOUN
admet-2961	427	15	among	among	ADP
admet-2961	427	16	well	well	ADV
admet-2961	427	17	-	-	PUNCT
admet-2961	427	18	stirred	stir	VERB
admet-2961	427	19	,	,	PUNCT
admet-2961	427	20	parallel	parallel	ADJ
admet-2961	427	21	-	-	PUNCT
admet-2961	427	22	tube	tube	NOUN
admet-2961	427	23	,	,	PUNCT
admet-2961	427	24	distributed	distribute	VERB
admet-2961	427	25	and	and	CCONJ
admet-2961	427	26	dispersion	dispersion	NOUN
admet-2961	427	27	models	model	NOUN
admet-2961	427	28	.	.	PUNCT
admet-2961	428	1	xenobiotica	xenobiotica	PROPN
admet-2961	428	2	35	35	NUM
admet-2961	428	3	(	(	PUNCT
admet-2961	428	4	2005	2005	NUM
admet-2961	428	5	)	)	PUNCT
admet-2961	428	6	627	627	NUM
admet-2961	428	7	-	-	SYM
admet-2961	428	8	646	646	NUM
admet-2961	428	9	.	.	PUNCT
admet-2961	428	10	http://doi.org/10.1080/00498250500159371	http://doi.org/10.1080/00498250500159371	X
admet-2961	429	1	[	[	X
admet-2961	429	2	62	62	NUM
admet-2961	429	3	]	]	X
admet-2961	429	4	y.r	y.r	PROPN
admet-2961	429	5	.	.	PROPN
admet-2961	429	6	ma	ma	PROPN
admet-2961	429	7	,	,	PUNCT
admet-2961	429	8	z.	z.	PROPN
admet-2961	429	9	rao	rao	PROPN
admet-2961	429	10	,	,	PUNCT
admet-2961	429	11	a.x	a.x	PROPN
admet-2961	429	12	.	.	PROPN
admet-2961	429	13	shi	shi	PROPN
admet-2961	429	14	,	,	PUNCT
admet-2961	429	15	y.f	y.f	PROPN
admet-2961	429	16	.	.	PROPN
admet-2961	429	17	wang	wang	PROPN
admet-2961	429	18	,	,	PUNCT
admet-2961	429	19	j.	j.	PROPN
admet-2961	429	20	huang	huang	PROPN
admet-2961	429	21	,	,	PUNCT
admet-2961	429	22	m.	m.	PROPN
admet-2961	429	23	han	han	PROPN
admet-2961	429	24	,	,	PUNCT
admet-2961	429	25	x.d	x.d	PROPN
admet-2961	429	26	.	.	PROPN
admet-2961	429	27	wang	wang	PROPN
admet-2961	429	28	,	,	PUNCT
admet-2961	429	29	y.w	y.w	PROPN
admet-2961	429	30	.	.	PROPN
admet-2961	429	31	jin	jin	PROPN
admet-2961	429	32	,	,	PUNCT
admet-2961	429	33	g.q	g.q	PROPN
admet-2961	429	34	.	.	PROPN
admet-2961	429	35	zhang	zhang	PROPN
admet-2961	429	36	,	,	PUNCT
admet-2961	429	37	y.	y.	PROPN
admet-2961	429	38	zhou	zhou	PROPN
admet-2961	429	39	,	,	PUNCT
admet-2961	429	40	f.	f.	PROPN
admet-2961	429	41	zhang	zhang	PROPN
admet-2961	429	42	,	,	PUNCT
admet-2961	429	43	h.y	h.y	PROPN
admet-2961	429	44	.	.	PROPN
admet-2961	429	45	qin	qin	PROPN
admet-2961	429	46	,	,	PUNCT
admet-2961	429	47	x.a	x.a	PROPN
admet-2961	429	48	.	.	PROPN
admet-2961	429	49	wu	wu	PROPN
admet-2961	429	50	.	.	PUNCT
admet-2961	430	1	simultaneous	simultaneous	ADJ
admet-2961	430	2	determination	determination	NOUN
admet-2961	430	3	of	of	ADP
admet-2961	430	4	metformin	metformin	PROPN
admet-2961	430	5	,	,	PUNCT
admet-2961	430	6	metoprolol	metoprolol	PROPN
admet-2961	430	7	and	and	CCONJ
admet-2961	430	8	its	its	PRON
admet-2961	430	9	metabolites	metabolite	NOUN
admet-2961	430	10	in	in	ADP
admet-2961	430	11	rat	rat	NOUN
admet-2961	430	12	plasma	plasma	NOUN
admet-2961	430	13	by	by	ADP
admet-2961	430	14	lc	lc	PROPN
admet-2961	430	15	-	-	PUNCT
admet-2961	430	16	ms	ms	PROPN
admet-2961	430	17	-	-	PUNCT
admet-2961	430	18	ms	ms	NOUN
admet-2961	430	19	:	:	PUNCT
admet-2961	430	20	application	application	NOUN
admet-2961	430	21	to	to	ADP
admet-2961	430	22	pharmacokinetic	pharmacokinetic	ADJ
admet-2961	430	23	interaction	interaction	NOUN
admet-2961	430	24	study	study	NOUN
admet-2961	430	25	.	.	PUNCT
admet-2961	431	1	journal	journal	PROPN
admet-2961	431	2	of	of	ADP
admet-2961	431	3	chromatographic	chromatographic	ADJ
admet-2961	431	4	science	science	NOUN
admet-2961	431	5	54	54	NUM
admet-2961	431	6	(	(	PUNCT
admet-2961	431	7	2016	2016	NUM
admet-2961	431	8	)	)	PUNCT
admet-2961	431	9	1	1	NUM
admet-2961	431	10	-	-	SYM
admet-2961	431	11	9	9	NUM
admet-2961	431	12	.	.	PUNCT
admet-2961	432	1	http://doi.org/10.1093/chromsci/bmv097	http://doi.org/10.1093/chromsci/bmv097	NOUN
admet-2961	433	1	[	[	X
admet-2961	433	2	63	63	NUM
admet-2961	433	3	]	]	PUNCT
admet-2961	433	4	x.	x.	NOUN
admet-2961	433	5	li	li	PROPN
admet-2961	433	6	,	,	PUNCT
admet-2961	433	7	g.	g.	PROPN
admet-2961	433	8	xing	xing	PROPN
admet-2961	433	9	,	,	PUNCT
admet-2961	433	10	x.	x.	PROPN
admet-2961	433	11	guo	guo	PROPN
admet-2961	433	12	,	,	PUNCT
admet-2961	433	13	y.	y.	PROPN
admet-2961	433	14	wang	wang	PROPN
admet-2961	433	15	,	,	PUNCT
admet-2961	433	16	z.	z.	PROPN
admet-2961	433	17	hu	hu	PROPN
admet-2961	433	18	,	,	PUNCT
admet-2961	433	19	m.	m.	PROPN
admet-2961	433	20	cheng	cheng	PROPN
admet-2961	433	21	,	,	PUNCT
admet-2961	433	22	y.	y.	PROPN
admet-2961	433	23	peng	peng	PROPN
admet-2961	433	24	,	,	PUNCT
admet-2961	433	25	j.	j.	PROPN
admet-2961	433	26	zheng	zheng	PROPN
admet-2961	433	27	.	.	PUNCT
admet-2961	434	1	identification	identification	NOUN
admet-2961	434	2	of	of	ADP
admet-2961	434	3	metoprolol	metoprolol	PROPN
admet-2961	434	4	tartratederived	tartratederive	VERB
admet-2961	434	5	reactive	reactive	ADJ
admet-2961	434	6	metabolites	metabolite	NOUN
admet-2961	434	7	possibly	possibly	ADV
admet-2961	434	8	correlated	correlate	VERB
admet-2961	434	9	with	with	ADP
admet-2961	434	10	its	its	PRON
admet-2961	434	11	cytotoxicity	cytotoxicity	NOUN
admet-2961	434	12	.	.	PUNCT
admet-2961	435	1	chemical	chemical	ADJ
admet-2961	435	2	research	research	NOUN
admet-2961	435	3	in	in	ADP
admet-2961	435	4	toxicology	toxicology	NOUN
admet-2961	435	5	35	35	NUM
admet-2961	435	6	(	(	PUNCT
admet-2961	435	7	2022	2022	NUM
admet-2961	435	8	)	)	PUNCT
admet-2961	435	9	1059	1059	NUM
admet-2961	435	10	-	-	SYM
admet-2961	435	11	1069	1069	NUM
admet-2961	435	12	.	.	PUNCT
admet-2961	436	1	http://doi.org/10.1021/acs.chemrestox.2c00052	http://doi.org/10.1021/acs.chemrestox.2c00052	PRON
admet-2961	437	1	[	[	X
admet-2961	437	2	64	64	NUM
admet-2961	437	3	]	]	PUNCT
admet-2961	437	4	b.	b.	PROPN
admet-2961	437	5	berger	berger	PROPN
admet-2961	437	6	,	,	PUNCT
admet-2961	437	7	f.	f.	PROPN
admet-2961	437	8	bachmann	bachmann	PROPN
admet-2961	437	9	,	,	PUNCT
admet-2961	437	10	u.	u.	PROPN
admet-2961	437	11	duthaler	duthaler	PROPN
admet-2961	437	12	,	,	PUNCT
admet-2961	437	13	s.	s.	PROPN
admet-2961	437	14	krähenbühl	krähenbühl	PROPN
admet-2961	437	15	,	,	PUNCT
admet-2961	437	16	m.	m.	NOUN
admet-2961	437	17	haschke	haschke	PROPN
admet-2961	437	18	.	.	PUNCT
admet-2961	438	1	cytochrome	cytochrome	PROPN
admet-2961	438	2	p450	p450	NUM
admet-2961	438	3	enzymes	enzyme	NOUN
admet-2961	438	4	involved	involve	VERB
admet-2961	438	5	in	in	ADP
admet-2961	438	6	metoprolol	metoprolol	NOUN
admet-2961	438	7	metabolism	metabolism	NOUN
admet-2961	438	8	and	and	CCONJ
admet-2961	438	9	use	use	NOUN
admet-2961	438	10	of	of	ADP
admet-2961	438	11	metoprolol	metoprolol	NOUN
admet-2961	438	12	as	as	ADP
admet-2961	438	13	a	a	DET
admet-2961	438	14	cyp2d6	cyp2d6	NOUN
admet-2961	438	15	phenotyping	phenotype	VERB
admet-2961	438	16	probe	probe	NOUN
admet-2961	438	17	drug	drug	NOUN
admet-2961	438	18	.	.	PUNCT
admet-2961	439	1	frontiers	frontier	NOUN
admet-2961	439	2	in	in	ADP
admet-2961	439	3	pharmacology	pharmacology	NOUN
admet-2961	439	4	9	9	NUM
admet-2961	439	5	(	(	PUNCT
admet-2961	439	6	2018	2018	NUM
admet-2961	439	7	)	)	PUNCT
admet-2961	439	8	774	774	NUM
admet-2961	439	9	.	.	PUNCT
admet-2961	440	1	http://doi.org/10.3389/fphar.2018.00774	http://doi.org/10.3389/fphar.2018.00774	PROPN
admet-2961	440	2	http://dx.doi.org/10.5599/admet.2961	http://dx.doi.org/10.5599/admet.2961	PROPN
admet-2961	440	3	http://doi.org/10.3109/00498254.2012.676693	http://doi.org/10.3109/00498254.2012.676693	PROPN
admet-2961	440	4	http://doi.org/10.1124/jpet.112.195834	http://doi.org/10.1124/jpet.112.195834	PROPN
admet-2961	440	5	http://doi.org/10.1124/dmd.33.1.115	http://doi.org/10.1124/dmd.33.1.115	PROPN
admet-2961	440	6	http://doi.org/10.1080/00498250400021820	http://doi.org/10.1080/00498250400021820	NOUN
admet-2961	440	7	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-drug-interactions-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-drug-interactions-revision-1_en.pdf	PROPN
admet-2961	440	8	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-drug-interactions-revision-1_en.pdf	https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-investigation-drug-interactions-revision-1_en.pdf	NOUN
admet-2961	440	9	http://doi.org/10.1002/psp4.12563	http://doi.org/10.1002/psp4.12563	NOUN
admet-2961	441	1	http://doi.org/10.1016/j.jchromb.2005.06.038	http://doi.org/10.1016/j.jchromb.2005.06.038	AUX
admet-2961	441	2	http://doi.org/10.1038/sj.clpt.6100054	http://doi.org/10.1038/sj.clpt.6100054	PROPN
admet-2961	441	3	https://doi.org/10.1016/s0090-9556(24)15081-7	https://doi.org/10.1016/s0090-9556(24)15081-7	PROPN
admet-2961	441	4	http://doi.org/10.1080/00498250500159371	http://doi.org/10.1080/00498250500159371	NOUN
admet-2961	441	5	http://doi.org/10.1093/chromsci/bmv097	http://doi.org/10.1093/chromsci/bmv097	ADV
admet-2961	441	6	http://doi.org/10.1021/acs.chemrestox.2c00052	http://doi.org/10.1021/acs.chemrestox.2c00052	PROPN
admet-2961	442	1	http://doi.org/10.3389/fphar.2018.00774	http://doi.org/10.3389/fphar.2018.00774	PROPN
admet-2961	442	2	j.	j.	PROPN
admet-2961	442	3	pu	pu	PROPN
admet-2961	442	4	et	et	PROPN
admet-2961	442	5	al	al	PROPN
admet-2961	442	6	.	.	PROPN
admet-2961	442	7	admet	admet	PROPN
admet-2961	442	8	&	&	CCONJ
admet-2961	442	9	dmpk	dmpk	PROPN
admet-2961	442	10	13(5	13(5	NUM
admet-2961	442	11	)	)	PUNCT
admet-2961	442	12	(	(	PUNCT
admet-2961	442	13	2025	2025	NUM
admet-2961	442	14	)	)	PUNCT
admet-2961	442	15	2961	2961	NUM
admet-2961	442	16	16	16	NUM
admet-2961	443	1	[	[	X
admet-2961	443	2	65	65	NUM
admet-2961	443	3	]	]	SYM
admet-2961	443	4	p.m.	p.m.	NOUN
admet-2961	443	5	cerqueira	cerqueira	PROPN
admet-2961	443	6	,	,	PUNCT
admet-2961	443	7	v.b	v.b	PROPN
admet-2961	443	8	.	.	PROPN
admet-2961	443	9	boralli	boralli	PROPN
admet-2961	443	10	,	,	PUNCT
admet-2961	443	11	e.b	e.b	PROPN
admet-2961	443	12	.	.	PROPN
admet-2961	443	13	coelho	coelho	PROPN
admet-2961	443	14	,	,	PUNCT
admet-2961	443	15	n.p	n.p	PROPN
admet-2961	443	16	.	.	PROPN
admet-2961	443	17	lopes	lopes	PROPN
admet-2961	443	18	,	,	PUNCT
admet-2961	443	19	l.f	l.f	PROPN
admet-2961	443	20	.	.	PROPN
admet-2961	443	21	lopes	lopes	PROPN
admet-2961	443	22	guimarães	guimarães	PROPN
admet-2961	443	23	,	,	PUNCT
admet-2961	443	24	p.s	p.s	PROPN
admet-2961	443	25	.	.	PROPN
admet-2961	443	26	bonato	bonato	PROPN
admet-2961	443	27	,	,	PUNCT
admet-2961	443	28	v.l	v.l	PROPN
admet-2961	443	29	.	.	PROPN
admet-2961	443	30	lanchote	lanchote	NOUN
admet-2961	443	31	.	.	PUNCT
admet-2961	444	1	enantioselective	enantioselective	ADJ
admet-2961	444	2	determination	determination	NOUN
admet-2961	444	3	of	of	ADP
admet-2961	444	4	metoprolol	metoprolol	PROPN
admet-2961	444	5	acidic	acidic	ADJ
admet-2961	444	6	metabolite	metabolite	NOUN
admet-2961	444	7	in	in	ADP
admet-2961	444	8	plasma	plasma	NOUN
admet-2961	444	9	and	and	CCONJ
admet-2961	444	10	urine	urine	NOUN
admet-2961	444	11	using	use	VERB
admet-2961	444	12	liquid	liquid	ADJ
admet-2961	444	13	chromatography	chromatography	NOUN
admet-2961	444	14	chiral	chiral	ADJ
admet-2961	444	15	columns	column	NOUN
admet-2961	444	16	:	:	PUNCT
admet-2961	444	17	applications	application	NOUN
admet-2961	444	18	to	to	ADP
admet-2961	444	19	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	444	20	.	.	PUNCT
admet-2961	445	1	journal	journal	NOUN
admet-2961	445	2	of	of	ADP
admet-2961	445	3	chromatography	chromatography	NOUN
admet-2961	445	4	b	b	PROPN
admet-2961	445	5	783	783	NUM
admet-2961	445	6	(	(	PUNCT
admet-2961	445	7	2003	2003	NUM
admet-2961	445	8	)	)	PUNCT
admet-2961	445	9	433	433	NUM
admet-2961	445	10	-	-	SYM
admet-2961	445	11	441	441	NUM
admet-2961	445	12	.	.	PUNCT
admet-2961	446	1	http://doi.org/10.1016/s1570-0232(02)00705-5	http://doi.org/10.1016/s1570-0232(02)00705-5	NOUN
admet-2961	447	1	[	[	X
admet-2961	447	2	66	66	NUM
admet-2961	447	3	]	]	PUNCT
admet-2961	447	4	t.	t.	PROPN
admet-2961	447	5	xu	xu	PROPN
admet-2961	447	6	,	,	PUNCT
admet-2961	447	7	s.	s.	PROPN
admet-2961	447	8	bao	bao	PROPN
admet-2961	447	9	,	,	PUNCT
admet-2961	447	10	p.	p.	PROPN
admet-2961	447	11	geng	geng	PROPN
admet-2961	447	12	,	,	PUNCT
admet-2961	447	13	j.	j.	PROPN
admet-2961	447	14	luo	luo	PROPN
admet-2961	447	15	,	,	PUNCT
admet-2961	447	16	l.	l.	PROPN
admet-2961	447	17	yu	yu	PROPN
admet-2961	447	18	,	,	PUNCT
admet-2961	447	19	p.	p.	PROPN
admet-2961	447	20	pan	pan	PROPN
admet-2961	447	21	,	,	PUNCT
admet-2961	447	22	y.	y.	PROPN
admet-2961	447	23	chen	chen	PROPN
admet-2961	447	24	,	,	PUNCT
admet-2961	447	25	g.	g.	PROPN
admet-2961	447	26	hu	hu	PROPN
admet-2961	447	27	.	.	PUNCT
admet-2961	448	1	determination	determination	NOUN
admet-2961	448	2	of	of	ADP
admet-2961	448	3	metoprolol	metoprolol	PROPN
admet-2961	448	4	and	and	CCONJ
admet-2961	448	5	its	its	PRON
admet-2961	448	6	two	two	NUM
admet-2961	448	7	metabolites	metabolite	NOUN
admet-2961	448	8	in	in	ADP
admet-2961	448	9	human	human	ADJ
admet-2961	448	10	plasma	plasma	NOUN
admet-2961	448	11	and	and	CCONJ
admet-2961	448	12	urine	urine	NOUN
admet-2961	448	13	by	by	ADP
admet-2961	448	14	high	high	ADJ
admet-2961	448	15	performance	performance	NOUN
admet-2961	448	16	liquid	liquid	NOUN
admet-2961	448	17	chromatography	chromatography	NOUN
admet-2961	448	18	with	with	ADP
admet-2961	448	19	fluorescence	fluorescence	NOUN
admet-2961	448	20	detection	detection	NOUN
admet-2961	448	21	and	and	CCONJ
admet-2961	448	22	its	its	PRON
admet-2961	448	23	application	application	NOUN
admet-2961	448	24	in	in	ADP
admet-2961	448	25	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	448	26	.	.	PUNCT
admet-2961	449	1	journal	journal	NOUN
admet-2961	449	2	of	of	ADP
admet-2961	449	3	chromatography	chromatography	PROPN
admet-2961	449	4	b	b	PROPN
admet-2961	449	5	937	937	NUM
admet-2961	449	6	(	(	PUNCT
admet-2961	449	7	2013	2013	NUM
admet-2961	449	8	)	)	PUNCT
admet-2961	449	9	60	60	NUM
admet-2961	449	10	-	-	SYM
admet-2961	449	11	66	66	NUM
admet-2961	449	12	.	.	PUNCT
admet-2961	450	1	http://doi.org/10.1016/j.jchromb.2013.08.017	http://doi.org/10.1016/j.jchromb.2013.08.017	NOUN
admet-2961	451	1	[	[	X
admet-2961	451	2	67	67	NUM
admet-2961	451	3	]	]	X
admet-2961	451	4	s.h	s.h	PROPN
admet-2961	451	5	.	.	PROPN
admet-2961	451	6	bae	bae	PROPN
admet-2961	451	7	,	,	PUNCT
admet-2961	451	8	j.k	j.k	PROPN
admet-2961	451	9	.	.	PROPN
admet-2961	451	10	lee	lee	PROPN
admet-2961	451	11	,	,	PUNCT
admet-2961	451	12	d.y	d.y	PROPN
admet-2961	451	13	.	.	PROPN
admet-2961	451	14	cho	cho	PROPN
admet-2961	451	15	,	,	PUNCT
admet-2961	451	16	s.k	s.k	PROPN
admet-2961	451	17	.	.	PROPN
admet-2961	451	18	bae	bae	PROPN
admet-2961	451	19	.	.	PUNCT
admet-2961	452	1	simultaneous	simultaneous	ADJ
admet-2961	452	2	determination	determination	NOUN
admet-2961	452	3	of	of	ADP
admet-2961	452	4	metoprolol	metoprolol	NOUN
admet-2961	452	5	and	and	CCONJ
admet-2961	452	6	its	its	PRON
admet-2961	452	7	metabolites	metabolite	NOUN
admet-2961	452	8	,	,	PUNCT
admet-2961	452	9	αhydroxymetoprolol	αhydroxymetoprolol	NOUN
admet-2961	452	10	and	and	CCONJ
admet-2961	452	11	o	o	NOUN
admet-2961	452	12	-	-	NOUN
admet-2961	452	13	desmethylmetoprolol	desmethylmetoprolol	NOUN
admet-2961	452	14	,	,	PUNCT
admet-2961	452	15	in	in	ADP
admet-2961	452	16	human	human	ADJ
admet-2961	452	17	plasma	plasma	NOUN
admet-2961	452	18	by	by	ADP
admet-2961	452	19	liquid	liquid	ADJ
admet-2961	452	20	chromatography	chromatography	NOUN
admet-2961	452	21	with	with	ADP
admet-2961	452	22	tandem	tandem	PROPN
admet-2961	452	23	mass	mass	PROPN
admet-2961	452	24	spectrometry	spectrometry	NOUN
admet-2961	452	25	:	:	PUNCT
admet-2961	452	26	application	application	NOUN
admet-2961	452	27	to	to	ADP
admet-2961	452	28	the	the	DET
admet-2961	452	29	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	452	30	of	of	ADP
admet-2961	452	31	metoprolol	metoprolol	NOUN
admet-2961	452	32	associated	associate	VERB
admet-2961	452	33	with	with	ADP
admet-2961	452	34	cyp2d6	cyp2d6	NOUN
admet-2961	452	35	genotypes	genotype	NOUN
admet-2961	452	36	.	.	PUNCT
admet-2961	453	1	journal	journal	PROPN
admet-2961	453	2	of	of	ADP
admet-2961	453	3	separation	separation	NOUN
admet-2961	453	4	science	science	NOUN
admet-2961	453	5	37	37	NUM
admet-2961	453	6	(	(	PUNCT
admet-2961	453	7	2014	2014	NUM
admet-2961	453	8	)	)	PUNCT
admet-2961	453	9	1256	1256	NUM
admet-2961	453	10	-	-	SYM
admet-2961	453	11	1264	1264	NUM
admet-2961	453	12	.	.	PUNCT
admet-2961	454	1	http://doi.org/10.1002/jssc.201301353	http://doi.org/10.1002/jssc.201301353	X
admet-2961	454	2	[	[	X
admet-2961	454	3	68	68	NUM
admet-2961	454	4	]	]	X
admet-2961	454	5	k.u	k.u	PROPN
admet-2961	454	6	.	.	PROPN
admet-2961	454	7	seiler	seiler	PROPN
admet-2961	454	8	,	,	PUNCT
admet-2961	454	9	k.j	k.j	PROPN
admet-2961	454	10	.	.	PROPN
admet-2961	454	11	schuster	schuster	PROPN
admet-2961	454	12	,	,	PUNCT
admet-2961	454	13	g.j	g.j	PROPN
admet-2961	454	14	.	.	PROPN
admet-2961	454	15	meyer	meyer	PROPN
admet-2961	454	16	,	,	PUNCT
admet-2961	454	17	w.	w.	PROPN
admet-2961	454	18	niedermayer	niedermayer	PROPN
admet-2961	454	19	,	,	PUNCT
admet-2961	454	20	o.	o.	PROPN
admet-2961	454	21	wassermann	wassermann	PROPN
admet-2961	454	22	.	.	PUNCT
admet-2961	455	1	the	the	DET
admet-2961	455	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	455	3	of	of	ADP
admet-2961	455	4	metoprolol	metoprolol	NOUN
admet-2961	455	5	and	and	CCONJ
admet-2961	455	6	its	its	PRON
admet-2961	455	7	metabolites	metabolite	NOUN
admet-2961	455	8	in	in	ADP
admet-2961	455	9	dialysis	dialysis	NOUN
admet-2961	455	10	patients	patient	NOUN
admet-2961	455	11	.	.	PUNCT
admet-2961	456	1	clinical	clinical	ADJ
admet-2961	456	2	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	456	3	5	5	NUM
admet-2961	456	4	(	(	PUNCT
admet-2961	456	5	1980	1980	NUM
admet-2961	456	6	)	)	PUNCT
admet-2961	456	7	192	192	NUM
admet-2961	456	8	-	-	SYM
admet-2961	456	9	198	198	NUM
admet-2961	456	10	.	.	PUNCT
admet-2961	456	11	http://doi.org/10.2165/00003088-198005020-00006	http://doi.org/10.2165/00003088-198005020-00006	PROPN
admet-2961	457	1	[	[	X
admet-2961	457	2	69	69	NUM
admet-2961	457	3	]	]	PUNCT
admet-2961	457	4	j.	j.	PROPN
admet-2961	457	5	fang	fang	PROPN
admet-2961	457	6	,	,	PUNCT
admet-2961	457	7	h.a	h.a	PROPN
admet-2961	457	8	.	.	PROPN
admet-2961	457	9	semple	semple	PROPN
admet-2961	457	10	,	,	PUNCT
admet-2961	457	11	j.	j.	PROPN
admet-2961	457	12	song	song	PROPN
admet-2961	457	13	.	.	PUNCT
admet-2961	458	1	determination	determination	NOUN
admet-2961	458	2	of	of	ADP
admet-2961	458	3	metoprolol	metoprolol	NOUN
admet-2961	458	4	,	,	PUNCT
admet-2961	458	5	and	and	CCONJ
admet-2961	458	6	its	its	PRON
admet-2961	458	7	four	four	NUM
admet-2961	458	8	metabolites	metabolite	NOUN
admet-2961	458	9	in	in	ADP
admet-2961	458	10	dog	dog	NOUN
admet-2961	458	11	plasma	plasma	NOUN
admet-2961	458	12	.	.	PUNCT
admet-2961	459	1	journal	journal	NOUN
admet-2961	459	2	of	of	ADP
admet-2961	459	3	chromatography	chromatography	PROPN
admet-2961	459	4	b	b	PROPN
admet-2961	459	5	809	809	NUM
admet-2961	459	6	(	(	PUNCT
admet-2961	459	7	2004	2004	NUM
admet-2961	459	8	)	)	PUNCT
admet-2961	459	9	9	9	NUM
admet-2961	459	10	-	-	SYM
admet-2961	459	11	14	14	NUM
admet-2961	459	12	.	.	PUNCT
admet-2961	460	1	http://doi.org/10.1016/j.jchromb.2004.05.029	http://doi.org/10.1016/j.jchromb.2004.05.029	NOUN
admet-2961	460	2	[	[	X
admet-2961	460	3	70	70	NUM
admet-2961	460	4	]	]	X
admet-2961	460	5	k.	k.	PROPN
admet-2961	460	6	bachmann	bachmann	PROPN
admet-2961	460	7	,	,	PUNCT
admet-2961	460	8	j.	j.	PROPN
admet-2961	460	9	byers	byers	PROPN
admet-2961	460	10	,	,	PUNCT
admet-2961	460	11	r.	r.	PROPN
admet-2961	460	12	ghosh	ghosh	PROPN
admet-2961	460	13	.	.	PUNCT
admet-2961	461	1	prediction	prediction	NOUN
admet-2961	461	2	of	of	ADP
admet-2961	461	3	in	in	ADP
admet-2961	461	4	vivo	vivo	ADJ
admet-2961	461	5	hepatic	hepatic	ADJ
admet-2961	461	6	clearance	clearance	NOUN
admet-2961	461	7	from	from	ADP
admet-2961	461	8	in	in	ADP
admet-2961	461	9	vitro	vitro	X
admet-2961	461	10	data	datum	NOUN
admet-2961	461	11	using	use	VERB
admet-2961	461	12	cryopreserved	cryopreserve	VERB
admet-2961	461	13	human	human	ADJ
admet-2961	461	14	hepatocytes	hepatocyte	NOUN
admet-2961	461	15	.	.	PUNCT
admet-2961	462	1	xenobiotica	xenobiotica	PROPN
admet-2961	462	2	33	33	NUM
admet-2961	462	3	(	(	PUNCT
admet-2961	462	4	2003	2003	NUM
admet-2961	462	5	)	)	PUNCT
admet-2961	462	6	475	475	NUM
admet-2961	462	7	-	-	SYM
admet-2961	462	8	483	483	NUM
admet-2961	462	9	.	.	PUNCT
admet-2961	462	10	http://doi.org/10.1080/0049825031000076177	http://doi.org/10.1080/0049825031000076177	X
admet-2961	463	1	[	[	X
admet-2961	463	2	71	71	NUM
admet-2961	463	3	]	]	PUNCT
admet-2961	463	4	j.	j.	PROPN
admet-2961	463	5	brian	brian	PROPN
admet-2961	463	6	houston	houston	PROPN
admet-2961	463	7	.	.	PUNCT
admet-2961	464	1	utility	utility	NOUN
admet-2961	464	2	of	of	ADP
admet-2961	464	3	in	in	ADP
admet-2961	464	4	vitro	vitro	X
admet-2961	464	5	drug	drug	NOUN
admet-2961	464	6	metabolism	metabolism	NOUN
admet-2961	464	7	data	datum	NOUN
admet-2961	464	8	in	in	ADP
admet-2961	464	9	predicting	predict	VERB
admet-2961	464	10	in	in	ADP
admet-2961	464	11	vivo	vivo	ADJ
admet-2961	464	12	metabolic	metabolic	NOUN
admet-2961	464	13	clearance	clearance	NOUN
admet-2961	464	14	.	.	PUNCT
admet-2961	465	1	biochemical	biochemical	ADJ
admet-2961	465	2	pharmacology	pharmacology	NOUN
admet-2961	465	3	47	47	NUM
admet-2961	465	4	(	(	PUNCT
admet-2961	465	5	1994	1994	NUM
admet-2961	465	6	)	)	PUNCT
admet-2961	465	7	1469	1469	NUM
admet-2961	465	8	-	-	SYM
admet-2961	465	9	1479	1479	NUM
admet-2961	465	10	.	.	PUNCT
admet-2961	466	1	http://doi.org/10.1016/0006-2952(94)90520-7	http://doi.org/10.1016/0006-2952(94)90520-7	NUM
admet-2961	466	2	[	[	X
admet-2961	466	3	72	72	NUM
admet-2961	466	4	]	]	X
admet-2961	466	5	b.	b.	PROPN
admet-2961	466	6	davies	davy	NOUN
admet-2961	466	7	,	,	PUNCT
admet-2961	466	8	t.	t.	PROPN
admet-2961	466	9	morris	morris	PROPN
admet-2961	466	10	.	.	PROPN
admet-2961	466	11	physiological	physiological	ADJ
admet-2961	466	12	parameters	parameter	NOUN
admet-2961	466	13	in	in	ADP
admet-2961	466	14	laboratory	laboratory	NOUN
admet-2961	466	15	animals	animal	NOUN
admet-2961	466	16	and	and	CCONJ
admet-2961	466	17	humans	human	NOUN
admet-2961	466	18	.	.	PUNCT
admet-2961	467	1	pharmaceutical	pharmaceutical	ADJ
admet-2961	467	2	research	research	NOUN
admet-2961	467	3	10	10	NUM
admet-2961	467	4	(	(	PUNCT
admet-2961	467	5	1993	1993	NUM
admet-2961	467	6	)	)	PUNCT
admet-2961	467	7	1093	1093	NUM
admet-2961	467	8	-	-	SYM
admet-2961	467	9	1095	1095	NUM
admet-2961	467	10	.	.	PUNCT
admet-2961	468	1	http://doi.org/10.1023/a:1018943613122	http://doi.org/10.1023/a:1018943613122	NOUN
admet-2961	469	1	[	[	PUNCT
admet-2961	469	2	73	73	NUM
admet-2961	469	3	]	]	PUNCT
admet-2961	469	4	j.	j.	PROPN
admet-2961	469	5	louisse	louisse	PROPN
admet-2961	469	6	,	,	PUNCT
admet-2961	469	7	m.	m.	NOUN
admet-2961	469	8	alewijn	alewijn	PROPN
admet-2961	469	9	,	,	PUNCT
admet-2961	469	10	a.a.c.m	a.a.c.m	PROPN
admet-2961	469	11	.	.	NOUN
admet-2961	469	12	peijnenburg	peijnenburg	NOUN
admet-2961	469	13	,	,	PUNCT
admet-2961	469	14	n.h.p	n.h.p	PROPN
admet-2961	469	15	.	.	PUNCT
admet-2961	469	16	cnubben	cnubben	PROPN
admet-2961	469	17	,	,	PUNCT
admet-2961	469	18	m.b	m.b	PROPN
admet-2961	469	19	.	.	PROPN
admet-2961	469	20	heringa	heringa	PROPN
admet-2961	469	21	,	,	PUNCT
admet-2961	469	22	s.	s.	PROPN
admet-2961	469	23	coecke	coecke	PROPN
admet-2961	469	24	,	,	PUNCT
admet-2961	469	25	a.	a.	NOUN
admet-2961	469	26	punt	punt	NOUN
admet-2961	469	27	.	.	PUNCT
admet-2961	470	1	towards	towards	ADP
admet-2961	470	2	harmonization	harmonization	NOUN
admet-2961	470	3	of	of	ADP
admet-2961	470	4	test	test	NOUN
admet-2961	470	5	methods	method	NOUN
admet-2961	470	6	for	for	ADP
admet-2961	470	7	in	in	ADP
admet-2961	470	8	vitro	vitro	X
admet-2961	470	9	hepatic	hepatic	ADJ
admet-2961	470	10	clearance	clearance	NOUN
admet-2961	470	11	studies	study	NOUN
admet-2961	470	12	.	.	PUNCT
admet-2961	471	1	toxicology	toxicology	NOUN
admet-2961	471	2	in	in	ADP
admet-2961	471	3	vitro	vitro	X
admet-2961	471	4	63	63	NUM
admet-2961	471	5	(	(	PUNCT
admet-2961	471	6	2020	2020	NUM
admet-2961	471	7	)	)	PUNCT
admet-2961	471	8	104722	104722	NUM
admet-2961	471	9	.	.	PUNCT
admet-2961	472	1	http://doi.org/10.1016/j.tiv.2019.104722	http://doi.org/10.1016/j.tiv.2019.104722	PUNCT
admet-2961	473	1	[	[	X
admet-2961	473	2	74	74	NUM
admet-2961	473	3	]	]	X
admet-2961	473	4	s.j	s.j	PROPN
admet-2961	473	5	.	.	PROPN
admet-2961	473	6	griffin	griffin	PROPN
admet-2961	473	7	,	,	PUNCT
admet-2961	473	8	j.b	j.b	PROPN
admet-2961	473	9	.	.	PROPN
admet-2961	473	10	houston	houston	PROPN
admet-2961	473	11	.	.	PUNCT
admet-2961	474	1	comparison	comparison	NOUN
admet-2961	474	2	of	of	ADP
admet-2961	474	3	fresh	fresh	ADJ
admet-2961	474	4	and	and	CCONJ
admet-2961	474	5	cryopreserved	cryopreserve	VERB
admet-2961	474	6	rat	rat	NOUN
admet-2961	474	7	hepatocyte	hepatocyte	NOUN
admet-2961	474	8	suspensions	suspension	NOUN
admet-2961	474	9	for	for	ADP
admet-2961	474	10	the	the	DET
admet-2961	474	11	prediction	prediction	NOUN
admet-2961	474	12	of	of	ADP
admet-2961	474	13	in	in	ADP
admet-2961	474	14	vitro	vitro	X
admet-2961	474	15	intrinsic	intrinsic	ADJ
admet-2961	474	16	clearance	clearance	NOUN
admet-2961	474	17	.	.	PUNCT
admet-2961	475	1	drug	drug	NOUN
admet-2961	475	2	metabolism	metabolism	NOUN
admet-2961	475	3	and	and	CCONJ
admet-2961	475	4	disposition	disposition	NOUN
admet-2961	475	5	32	32	NUM
admet-2961	475	6	(	(	PUNCT
admet-2961	475	7	2004	2004	NUM
admet-2961	475	8	)	)	PUNCT
admet-2961	475	9	552	552	NUM
admet-2961	475	10	-	-	SYM
admet-2961	475	11	558	558	NUM
admet-2961	475	12	.	.	PUNCT
admet-2961	476	1	http://doi.org/10.1124/dmd.32.5.552	http://doi.org/10.1124/dmd.32.5.552	PRON
admet-2961	476	2	[	[	X
admet-2961	476	3	75	75	NUM
admet-2961	476	4	]	]	PUNCT
admet-2961	476	5	c.	c.	PROPN
admet-2961	476	6	quarterman	quarterman	PROPN
admet-2961	476	7	,	,	PUNCT
admet-2961	476	8	m.	m.	PROPN
admet-2961	476	9	kendall	kendall	PROPN
admet-2961	476	10	,	,	PUNCT
admet-2961	476	11	d.	d.	PROPN
admet-2961	476	12	jack	jack	PROPN
admet-2961	476	13	.	.	PUNCT
admet-2961	477	1	the	the	DET
admet-2961	477	2	effect	effect	NOUN
admet-2961	477	3	of	of	ADP
admet-2961	477	4	age	age	NOUN
admet-2961	477	5	on	on	ADP
admet-2961	477	6	the	the	DET
admet-2961	477	7	pharmacokinetics	pharmacokinetic	NOUN
admet-2961	477	8	of	of	ADP
admet-2961	477	9	metoprolol	metoprolol	NOUN
admet-2961	477	10	and	and	CCONJ
admet-2961	477	11	its	its	PRON
admet-2961	477	12	metabolites	metabolite	NOUN
admet-2961	477	13	.	.	PUNCT
admet-2961	478	1	british	british	ADJ
admet-2961	478	2	journal	journal	PROPN
admet-2961	478	3	of	of	ADP
admet-2961	478	4	clinical	clinical	ADJ
admet-2961	478	5	pharmacology	pharmacology	NOUN
admet-2961	478	6	11	11	NUM
admet-2961	478	7	(	(	PUNCT
admet-2961	478	8	1981	1981	NUM
admet-2961	478	9	)	)	PUNCT
admet-2961	478	10	287	287	NUM
admet-2961	478	11	-	-	SYM
admet-2961	478	12	294	294	NUM
admet-2961	478	13	.	.	PUNCT
admet-2961	479	1	http://doi.org/10.1111/j.1365-2125.1981.tb00536.x	http://doi.org/10.1111/j.1365-2125.1981.tb00536.x	PROPN
admet-2961	479	2	[	[	X
admet-2961	479	3	76	76	NUM
admet-2961	479	4	]	]	X
admet-2961	479	5	r.m	r.m	PROPN
admet-2961	479	6	.	.	PROPN
admet-2961	479	7	borkar	borkar	PROPN
admet-2961	479	8	,	,	PUNCT
admet-2961	479	9	m.m	m.m	PROPN
admet-2961	479	10	.	.	PROPN
admet-2961	479	11	bhandi	bhandi	PROPN
admet-2961	479	12	,	,	PUNCT
admet-2961	479	13	a.p	a.p	PROPN
admet-2961	479	14	.	.	PROPN
admet-2961	479	15	dubey	dubey	PROPN
admet-2961	479	16	,	,	PUNCT
admet-2961	479	17	v.	v.	PROPN
admet-2961	479	18	ganga	ganga	PROPN
admet-2961	479	19	reddy	reddy	PROPN
admet-2961	479	20	,	,	PUNCT
admet-2961	479	21	p.	p.	PROPN
admet-2961	479	22	komirishetty	komirishetty	PROPN
admet-2961	479	23	,	,	PUNCT
admet-2961	479	24	p.p	p.p	PROPN
admet-2961	479	25	.	.	PROPN
admet-2961	479	26	nandekar	nandekar	PROPN
admet-2961	479	27	,	,	PUNCT
admet-2961	479	28	a.t	a.t	PROPN
admet-2961	479	29	.	.	PROPN
admet-2961	479	30	sangamwar	sangamwar	PROPN
admet-2961	479	31	,	,	PUNCT
admet-2961	479	32	a.	a.	PROPN
admet-2961	479	33	kamal	kamal	PROPN
admet-2961	479	34	,	,	PUNCT
admet-2961	479	35	s.k	s.k	PROPN
admet-2961	479	36	.	.	PROPN
admet-2961	479	37	banerjee	banerjee	PROPN
admet-2961	479	38	,	,	PUNCT
admet-2961	479	39	r.	r.	PROPN
admet-2961	479	40	srinivas	srinivas	PROPN
admet-2961	479	41	.	.	PUNCT
admet-2961	480	1	an	an	DET
admet-2961	480	2	evaluation	evaluation	NOUN
admet-2961	480	3	of	of	ADP
admet-2961	480	4	the	the	DET
admet-2961	480	5	cyp2d6	cyp2d6	NOUN
admet-2961	480	6	and	and	CCONJ
admet-2961	480	7	cyp3a4	cyp3a4	NOUN
admet-2961	480	8	inhibition	inhibition	NOUN
admet-2961	480	9	potential	potential	NOUN
admet-2961	480	10	of	of	ADP
admet-2961	480	11	metoprolol	metoprolol	NOUN
admet-2961	480	12	metabolites	metabolite	NOUN
admet-2961	480	13	and	and	CCONJ
admet-2961	480	14	their	their	PRON
admet-2961	480	15	contribution	contribution	NOUN
admet-2961	480	16	to	to	ADP
admet-2961	480	17	drug	drug	NOUN
admet-2961	480	18	-	-	PUNCT
admet-2961	480	19	drug	drug	NOUN
admet-2961	480	20	and	and	CCONJ
admet-2961	480	21	drug	drug	NOUN
admet-2961	480	22	-	-	PUNCT
admet-2961	480	23	herb	herb	NOUN
admet-2961	480	24	interaction	interaction	NOUN
admet-2961	480	25	by	by	ADP
admet-2961	480	26	lc	lc	PROPN
admet-2961	480	27	-	-	PUNCT
admet-2961	480	28	esi	esi	PROPN
admet-2961	480	29	/	/	SYM
admet-2961	480	30	ms	ms	PROPN
admet-2961	480	31	/	/	SYM
admet-2961	480	32	ms	ms	PROPN
admet-2961	480	33	.	.	PROPN
admet-2961	480	34	biomedical	biomedical	PROPN
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admet-2961	480	36	30	30	NUM
admet-2961	480	37	(	(	PUNCT
admet-2961	480	38	2016	2016	NUM
admet-2961	480	39	)	)	PUNCT
admet-2961	480	40	1556	1556	NUM
admet-2961	480	41	-	-	SYM
admet-2961	480	42	1572	1572	NUM
admet-2961	480	43	.	.	PUNCT
admet-2961	481	1	http://doi.org/10.1002/bmc.3721	http://doi.org/10.1002/bmc.3721	PROPN
admet-2961	482	1	[	[	X
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admet-2961	482	3	]	]	X
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admet-2961	482	6	,	,	PUNCT
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admet-2961	482	8	eisenhandler	eisenhandler	PROPN
admet-2961	482	9	,	,	PUNCT
admet-2961	482	10	y.	y.	PROPN
admet-2961	482	11	kuo	kuo	PROPN
admet-2961	482	12	,	,	PUNCT
admet-2961	482	13	p.	p.	PROPN
admet-2961	482	14	rearden	rearden	PROPN
admet-2961	482	15	,	,	PUNCT
admet-2961	482	16	y.	y.	PROPN
admet-2961	482	17	li	li	PROPN
admet-2961	482	18	,	,	PUNCT
admet-2961	482	19	p.j	p.j	PROPN
admet-2961	482	20	.	.	PROPN
admet-2961	482	21	manley	manley	PROPN
admet-2961	482	22	,	,	PUNCT
admet-2961	482	23	s.	s.	PROPN
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admet-2961	482	25	,	,	PUNCT
admet-2961	482	26	k.	k.	PROPN
admet-2961	482	27	menzel	menzel	PROPN
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admet-2961	483	1	prediction	prediction	NOUN
admet-2961	483	2	of	of	ADP
admet-2961	483	3	metabolic	metabolic	NOUN
admet-2961	483	4	clearance	clearance	NOUN
admet-2961	483	5	for	for	ADP
admet-2961	483	6	low	low	ADJ
admet-2961	483	7	-	-	PUNCT
admet-2961	483	8	turnover	turnover	NOUN
admet-2961	483	9	compounds	compound	NOUN
admet-2961	483	10	using	use	VERB
admet-2961	483	11	plated	plate	VERB
admet-2961	483	12	hepatocytes	hepatocyte	NOUN
admet-2961	483	13	with	with	ADP
admet-2961	483	14	enzyme	enzyme	NOUN
admet-2961	483	15	activity	activity	NOUN
admet-2961	483	16	correction	correction	NOUN
admet-2961	483	17	.	.	PUNCT
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admet-2961	484	2	journal	journal	PROPN
admet-2961	484	3	of	of	ADP
admet-2961	484	4	drug	drug	NOUN
admet-2961	484	5	metabolism	metabolism	NOUN
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admet-2961	484	9	(	(	PUNCT
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admet-2961	484	11	)	)	PUNCT
admet-2961	484	12	319	319	NUM
admet-2961	484	13	-	-	SYM
admet-2961	484	14	326	326	NUM
admet-2961	484	15	.	.	PUNCT
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admet-2961	486	2	2025	2025	NUM
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admet-2961	486	4	the	the	DET
admet-2961	486	5	authors	author	NOUN
admet-2961	486	6	;	;	PUNCT
admet-2961	486	7	licensee	licensee	PROPN
admet-2961	486	8	iapc	iapc	PROPN
admet-2961	486	9	,	,	PUNCT
admet-2961	486	10	zagreb	zagreb	PROPN
admet-2961	486	11	,	,	PUNCT
admet-2961	486	12	croatia	croatia	PROPN
admet-2961	486	13	.	.	PUNCT
admet-2961	487	1	this	this	DET
admet-2961	487	2	article	article	NOUN
admet-2961	487	3	is	be	AUX
admet-2961	487	4	an	an	DET
admet-2961	487	5	open	open	ADJ
admet-2961	487	6	-	-	PUNCT
admet-2961	487	7	access	access	NOUN
admet-2961	487	8	article	article	NOUN
admet-2961	487	9	distributed	distribute	VERB
admet-2961	487	10	under	under	ADP
admet-2961	487	11	the	the	DET
admet-2961	487	12	terms	term	NOUN
admet-2961	487	13	and	and	CCONJ
admet-2961	487	14	conditions	condition	NOUN
admet-2961	487	15	of	of	ADP
admet-2961	487	16	the	the	DET
admet-2961	487	17	creative	creative	ADJ
admet-2961	487	18	commons	common	NOUN
admet-2961	487	19	attribution	attribution	NOUN
admet-2961	487	20	license	license	NOUN
admet-2961	487	21	(	(	PUNCT
admet-2961	487	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2961	487	23	)	)	PUNCT
admet-2961	487	24	http://doi.org/10.1016/s1570-0232(02)00705-5	http://doi.org/10.1016/s1570-0232(02)00705-5	VERB
admet-2961	487	25	http://doi.org/10.1016/j.jchromb.2013.08.017	http://doi.org/10.1016/j.jchromb.2013.08.017	PROPN
admet-2961	487	26	http://doi.org/10.1002/jssc.201301353	http://doi.org/10.1002/jssc.201301353	NOUN
admet-2961	487	27	http://doi.org/10.2165/00003088-198005020-00006	http://doi.org/10.2165/00003088-198005020-00006	ADJ
admet-2961	487	28	http://doi.org/10.1016/j.jchromb.2004.05.029	http://doi.org/10.1016/j.jchromb.2004.05.029	NOUN
admet-2961	487	29	http://doi.org/10.1080/0049825031000076177	http://doi.org/10.1080/0049825031000076177	CCONJ
admet-2961	487	30	http://doi.org/10.1016/0006-2952(94)90520-7	http://doi.org/10.1016/0006-2952(94)90520-7	PROPN
admet-2961	487	31	http://doi.org/10.1023/a:1018943613122	http://doi.org/10.1023/a:1018943613122	NOUN
admet-2961	487	32	http://doi.org/10.1016/j.tiv.2019.104722	http://doi.org/10.1016/j.tiv.2019.104722	PRON
admet-2961	487	33	http://doi.org/10.1124/dmd.32.5.552	http://doi.org/10.1124/dmd.32.5.552	PRON
admet-2961	487	34	http://doi.org/10.1111/j.1365-2125.1981.tb00536.x	http://doi.org/10.1111/j.1365-2125.1981.tb00536.x	PROPN
admet-2961	487	35	http://doi.org/10.1002/bmc.3721	http://doi.org/10.1002/bmc.3721	PROPN
admet-2961	487	36	http://doi.org/10.1007/s13318-016-0336-3	http://doi.org/10.1007/s13318-016-0336-3	PROPN
admet-2961	487	37	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN