id	sid	tid	token	lemma	pos
admet-2988	1	1	advancing	advance	VERB
admet-2988	1	2	through	through	ADP
admet-2988	1	3	the	the	DET
admet-2988	1	4	blood	blood	NOUN
admet-2988	1	5	-	-	PUNCT
admet-2988	1	6	brain	brain	NOUN
admet-2988	1	7	barrier	barrier	NOUN
admet-2988	1	8	:	:	PUNCT
admet-2988	1	9	mechanisms	mechanism	NOUN
admet-2988	1	10	,	,	PUNCT
admet-2988	1	11	challenges	challenge	NOUN
admet-2988	1	12	and	and	CCONJ
admet-2988	1	13	drug	drug	NOUN
admet-2988	1	14	delivery	delivery	NOUN
admet-2988	1	15	strategies	strategy	NOUN
admet-2988	1	16	doi	doi	NOUN
admet-2988	1	17	:	:	PUNCT
admet-2988	1	18	http://doi.org/10.5599/admet.2988	http://doi.org/10.5599/admet.2988	ADJ
admet-2988	1	19	1	1	NUM
admet-2988	1	20	admet	admet	X
admet-2988	1	21	&	&	CCONJ
admet-2988	1	22	dmpk	dmpk	PROPN
admet-2988	1	23	13(5	13(5	NUM
admet-2988	1	24	)	)	PUNCT
admet-2988	1	25	(	(	PUNCT
admet-2988	1	26	2025	2025	NUM
admet-2988	1	27	)	)	PUNCT
admet-2988	1	28	2988	2988	NUM
admet-2988	1	29	;	;	PUNCT
admet-2988	1	30	doi	doi	NOUN
admet-2988	1	31	:	:	PUNCT
admet-2988	1	32	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	ADJ
admet-2988	1	33	open	open	ADJ
admet-2988	1	34	access	access	NOUN
admet-2988	1	35	:	:	PUNCT
admet-2988	1	36	issn	issn	PROPN
admet-2988	1	37	:	:	PUNCT
admet-2988	1	38	1848	1848	NUM
admet-2988	1	39	-	-	SYM
admet-2988	1	40	7718	7718	NUM
admet-2988	1	41	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	NOUN
admet-2988	1	42	review	review	NOUN
admet-2988	1	43	paper	paper	NOUN
admet-2988	1	44	advancing	advance	VERB
admet-2988	1	45	through	through	ADP
admet-2988	1	46	the	the	DET
admet-2988	1	47	blood	blood	NOUN
admet-2988	1	48	-	-	PUNCT
admet-2988	1	49	brain	brain	NOUN
admet-2988	1	50	barrier	barrier	NOUN
admet-2988	1	51	:	:	PUNCT
admet-2988	1	52	mechanisms	mechanism	NOUN
admet-2988	1	53	,	,	PUNCT
admet-2988	1	54	challenges	challenge	NOUN
admet-2988	1	55	and	and	CCONJ
admet-2988	1	56	drug	drug	NOUN
admet-2988	1	57	delivery	delivery	NOUN
admet-2988	1	58	strategies	strategy	NOUN
admet-2988	1	59	ronny	ronny	VERB
admet-2988	1	60	vargas1,2	vargas1,2	PROPN
admet-2988	1	61	*	*	PROPN
admet-2988	1	62	,	,	PUNCT
admet-2988	1	63	noelia	noelia	PROPN
admet-2988	1	64	martinez	martinez	PROPN
admet-2988	1	65	-	-	PUNCT
admet-2988	1	66	martinez1,3	martinez1,3	PROPN
admet-2988	1	67	,	,	PUNCT
admet-2988	1	68	catalina	catalina	NOUN
admet-2988	1	69	lizano	lizano	NOUN
admet-2988	1	70	-	-	NOUN
admet-2988	1	71	barrantes4	barrantes4	NOUN
admet-2988	1	72	,	,	PUNCT
admet-2988	1	73	jorge	jorge	NOUN
admet-2988	1	74	andrés	andrés	PROPN
admet-2988	1	75	pacheco	pacheco	PROPN
admet-2988	1	76	-	-	PUNCT
admet-2988	1	77	molina2	molina2	PROPN
admet-2988	1	78	,	,	PUNCT
admet-2988	1	79	encarna	encarna	ADJ
admet-2988	1	80	garcía	garcía	NOUN
admet-2988	1	81	-	-	PUNCT
admet-2988	1	82	montoya1,5	montoya1,5	PROPN
admet-2988	1	83	;	;	PUNCT
admet-2988	1	84	pilar	pilar	PROPN
admet-2988	1	85	pérez	pérez	NOUN
admet-2988	1	86	-	-	PUNCT
admet-2988	1	87	lozano1,5	lozano1,5	PROPN
admet-2988	1	88	,	,	PUNCT
admet-2988	1	89	josep	josep	PROPN
admet-2988	1	90	mª	mª	PROPN
admet-2988	1	91	suñé	suñé	PROPN
admet-2988	1	92	-	-	PUNCT
admet-2988	1	93	negre1,5	negre1,5	PROPN
admet-2988	1	94	,	,	PUNCT
admet-2988	1	95	carlos	carlos	PROPN
admet-2988	1	96	suñé3	suñé3	PROPN
admet-2988	1	97	*	*	PROPN
admet-2988	1	98	*	*	PROPN
admet-2988	1	99	and	and	CCONJ
admet-2988	1	100	marc	marc	PROPN
admet-2988	1	101	suñé	suñé	PROPN
admet-2988	1	102	-	-	PUNCT
admet-2988	1	103	pou1,5	pou1,5	NUM
admet-2988	1	104	1department	1department	NUM
admet-2988	1	105	of	of	ADP
admet-2988	1	106	pharmacy	pharmacy	NOUN
admet-2988	1	107	and	and	CCONJ
admet-2988	1	108	pharmaceutical	pharmaceutical	NOUN
admet-2988	1	109	technology	technology	NOUN
admet-2988	1	110	,	,	PUNCT
admet-2988	1	111	and	and	CCONJ
admet-2988	1	112	physical	physical	ADJ
admet-2988	1	113	chemistry	chemistry	NOUN
admet-2988	1	114	,	,	PUNCT
admet-2988	1	115	faculty	faculty	NOUN
admet-2988	1	116	of	of	ADP
admet-2988	1	117	pharmacy	pharmacy	NOUN
admet-2988	1	118	,	,	PUNCT
admet-2988	1	119	university	university	PROPN
admet-2988	1	120	of	of	ADP
admet-2988	1	121	barcelona	barcelona	PROPN
admet-2988	1	122	,	,	PUNCT
admet-2988	1	123	barcelona	barcelona	PROPN
admet-2988	1	124	,	,	PUNCT
admet-2988	1	125	spain	spain	PROPN
admet-2988	1	126	2department	2department	NUM
admet-2988	1	127	of	of	ADP
admet-2988	1	128	industrial	industrial	ADJ
admet-2988	1	129	pharmacy	pharmacy	NOUN
admet-2988	1	130	,	,	PUNCT
admet-2988	1	131	faculty	faculty	NOUN
admet-2988	1	132	of	of	ADP
admet-2988	1	133	pharmacy	pharmacy	NOUN
admet-2988	1	134	,	,	PUNCT
admet-2988	1	135	universidad	universidad	PROPN
admet-2988	1	136	de	de	PROPN
admet-2988	1	137	costa	costa	PROPN
admet-2988	1	138	rica	rica	PROPN
admet-2988	1	139	,	,	PUNCT
admet-2988	1	140	san	san	PROPN
admet-2988	1	141	josé	josé	PROPN
admet-2988	1	142	,	,	PUNCT
admet-2988	1	143	costa	costa	PROPN
admet-2988	1	144	rica	rica	PROPN
admet-2988	2	1	3department	3department	NUM
admet-2988	2	2	of	of	ADP
admet-2988	2	3	molecular	molecular	ADJ
admet-2988	2	4	biology	biology	NOUN
admet-2988	2	5	,	,	PUNCT
admet-2988	2	6	institute	institute	NOUN
admet-2988	2	7	of	of	ADP
admet-2988	2	8	parasitology	parasitology	NOUN
admet-2988	2	9	and	and	CCONJ
admet-2988	2	10	biomedicine	biomedicine	NOUN
admet-2988	2	11	“	"	PUNCT
admet-2988	2	12	lópez	lópez	NOUN
admet-2988	2	13	-	-	PUNCT
admet-2988	2	14	neyra	neyra	NOUN
admet-2988	2	15	”	"	PUNCT
admet-2988	2	16	(	(	PUNCT
admet-2988	2	17	ipbln	ipbln	VERB
admet-2988	2	18	-	-	PUNCT
admet-2988	2	19	csic	csic	NOUN
admet-2988	2	20	)	)	PUNCT
admet-2988	2	21	,	,	PUNCT
admet-2988	2	22	granada	granada	PROPN
admet-2988	2	23	,	,	PUNCT
admet-2988	2	24	spain	spain	PROPN
admet-2988	2	25	4department	4department	NUM
admet-2988	2	26	of	of	ADP
admet-2988	2	27	pharmaceutical	pharmaceutical	NOUN
admet-2988	2	28	care	care	NOUN
admet-2988	2	29	and	and	CCONJ
admet-2988	2	30	clinical	clinical	ADJ
admet-2988	2	31	pharmacy	pharmacy	NOUN
admet-2988	2	32	,	,	PUNCT
admet-2988	2	33	faculty	faculty	NOUN
admet-2988	2	34	of	of	ADP
admet-2988	2	35	pharmacy	pharmacy	NOUN
admet-2988	2	36	,	,	PUNCT
admet-2988	2	37	universidad	universidad	PROPN
admet-2988	2	38	de	de	PROPN
admet-2988	2	39	costa	costa	PROPN
admet-2988	2	40	rica	rica	PROPN
admet-2988	2	41	,	,	PUNCT
admet-2988	2	42	san	san	PROPN
admet-2988	2	43	josé	josé	PROPN
admet-2988	2	44	,	,	PUNCT
admet-2988	2	45	costa	costa	PROPN
admet-2988	2	46	rica	rica	PROPN
admet-2988	2	47	5pharmacotherapy	5pharmacotherapy	NUM
admet-2988	2	48	,	,	PUNCT
admet-2988	2	49	pharmacogenetics	pharmacogenetic	NOUN
admet-2988	2	50	and	and	CCONJ
admet-2988	2	51	pharmaceutical	pharmaceutical	NOUN
admet-2988	2	52	technology	technology	NOUN
admet-2988	2	53	research	research	NOUN
admet-2988	2	54	group	group	NOUN
admet-2988	2	55	bellvitge	bellvitge	VERB
admet-2988	2	56	biomedical	biomedical	ADJ
admet-2988	2	57	research	research	PROPN
admet-2988	2	58	institute	institute	PROPN
admet-2988	2	59	(	(	PUNCT
admet-2988	2	60	idibell	idibell	PROPN
admet-2988	2	61	)	)	PUNCT
admet-2988	2	62	,	,	PUNCT
admet-2988	2	63	barcelona	barcelona	PROPN
admet-2988	2	64	,	,	PUNCT
admet-2988	2	65	spain	spain	PROPN
admet-2988	2	66	corresponding	correspond	VERB
admet-2988	2	67	authors	author	NOUN
admet-2988	2	68	e	e	NOUN
admet-2988	2	69	-	-	NOUN
admet-2988	2	70	mail	mail	NOUN
admet-2988	2	71	:	:	PUNCT
admet-2988	2	72	*	*	PUNCT
admet-2988	2	73	ronny.vargas_m@ucr.ac.cr	ronny.vargas_m@ucr.ac.cr	ADJ
admet-2988	2	74	,	,	PUNCT
admet-2988	2	75	*	*	PUNCT
admet-2988	2	76	*	*	NOUN
admet-2988	2	77	csune@ipb.csic.es	csune@ipb.csic.es	NOUN
admet-2988	2	78	;	;	PUNCT
admet-2988	2	79	tel.:+506	tel.:+506	NOUN
admet-2988	2	80	-	-	SYM
admet-2988	2	81	2511	2511	NUM
admet-2988	2	82	-	-	PUNCT
admet-2988	2	83	8340,+34958	8340,+34958	NUM
admet-2988	2	84	-	-	PUNCT
admet-2988	2	85	181645	181645	NUM
admet-2988	2	86	received	receive	VERB
admet-2988	2	87	:	:	PUNCT
admet-2988	2	88	september	september	PROPN
admet-2988	2	89	1	1	NUM
admet-2988	2	90	,	,	PUNCT
admet-2988	2	91	2025	2025	NUM
admet-2988	2	92	;	;	PUNCT
admet-2988	2	93	revised	revise	VERB
admet-2988	2	94	:	:	PUNCT
admet-2988	2	95	october	october	PROPN
admet-2988	2	96	16	16	NUM
admet-2988	2	97	,	,	PUNCT
admet-2988	2	98	2025	2025	NUM
admet-2988	2	99	;	;	PUNCT
admet-2988	2	100	published	publish	VERB
admet-2988	2	101	:	:	PUNCT
admet-2988	2	102	october	october	PROPN
admet-2988	2	103	19	19	NUM
admet-2988	2	104	,	,	PUNCT
admet-2988	2	105	2025	2025	NUM
admet-2988	2	106	abstract	abstract	ADJ
admet-2988	2	107	background	background	NOUN
admet-2988	2	108	and	and	CCONJ
admet-2988	2	109	purpose	purpose	NOUN
admet-2988	2	110	:	:	PUNCT
admet-2988	2	111	the	the	DET
admet-2988	2	112	delivery	delivery	NOUN
admet-2988	2	113	of	of	ADP
admet-2988	2	114	therapeutics	therapeutic	NOUN
admet-2988	2	115	to	to	ADP
admet-2988	2	116	the	the	DET
admet-2988	2	117	central	central	ADJ
admet-2988	2	118	nervous	nervous	ADJ
admet-2988	2	119	system	system	NOUN
admet-2988	2	120	(	(	PUNCT
admet-2988	2	121	cns	cns	NOUN
admet-2988	2	122	)	)	PUNCT
admet-2988	2	123	remains	remain	VERB
admet-2988	2	124	a	a	DET
admet-2988	2	125	major	major	ADJ
admet-2988	2	126	challenge	challenge	NOUN
admet-2988	2	127	due	due	ADP
admet-2988	2	128	to	to	ADP
admet-2988	2	129	the	the	DET
admet-2988	2	130	restrictive	restrictive	ADJ
admet-2988	2	131	nature	nature	NOUN
admet-2988	2	132	of	of	ADP
admet-2988	2	133	the	the	DET
admet-2988	2	134	blood	blood	NOUN
admet-2988	2	135	-	-	PUNCT
admet-2988	2	136	brain	brain	NOUN
admet-2988	2	137	barrier	barrier	NOUN
admet-2988	2	138	(	(	PUNCT
admet-2988	2	139	bbb	bbb	PROPN
admet-2988	2	140	)	)	PUNCT
admet-2988	2	141	,	,	PUNCT
admet-2988	2	142	a	a	DET
admet-2988	2	143	key	key	ADJ
admet-2988	2	144	evolutionary	evolutionary	ADJ
admet-2988	2	145	feature	feature	NOUN
admet-2988	2	146	that	that	PRON
admet-2988	2	147	preserves	preserve	VERB
admet-2988	2	148	brain	brain	NOUN
admet-2988	2	149	homeostasis	homeostasis	NOUN
admet-2988	2	150	.	.	PUNCT
admet-2988	3	1	this	this	DET
admet-2988	3	2	review	review	NOUN
admet-2988	3	3	seeks	seek	VERB
admet-2988	3	4	to	to	PART
admet-2988	3	5	synthesize	synthesize	VERB
admet-2988	3	6	current	current	ADJ
admet-2988	3	7	knowledge	knowledge	NOUN
admet-2988	3	8	on	on	ADP
admet-2988	3	9	bbb	bbb	PROPN
admet-2988	3	10	composition	composition	NOUN
admet-2988	3	11	,	,	PUNCT
admet-2988	3	12	physiology	physiology	NOUN
admet-2988	3	13	,	,	PUNCT
admet-2988	3	14	and	and	CCONJ
admet-2988	3	15	transport	transport	NOUN
admet-2988	3	16	mechanisms	mechanism	NOUN
admet-2988	3	17	,	,	PUNCT
admet-2988	3	18	and	and	CCONJ
admet-2988	3	19	critically	critically	ADV
admet-2988	3	20	analyses	analyse	VERB
admet-2988	3	21	drug	drug	NOUN
admet-2988	3	22	delivery	delivery	NOUN
admet-2988	3	23	strategies	strategy	NOUN
admet-2988	3	24	aimed	aim	VERB
admet-2988	3	25	at	at	ADP
admet-2988	3	26	overcoming	overcome	VERB
admet-2988	3	27	this	this	DET
admet-2988	3	28	barrier	barrier	NOUN
admet-2988	3	29	and	and	CCONJ
admet-2988	3	30	enabling	enable	VERB
admet-2988	3	31	effective	effective	ADJ
admet-2988	3	32	cns	cns	NOUN
admet-2988	3	33	therapies	therapy	NOUN
admet-2988	3	34	.	.	PUNCT
admet-2988	4	1	approach	approach	NOUN
admet-2988	4	2	:	:	PUNCT
admet-2988	4	3	we	we	PRON
admet-2988	4	4	conducted	conduct	VERB
admet-2988	4	5	a	a	DET
admet-2988	4	6	comprehensive	comprehensive	ADJ
admet-2988	4	7	narrative	narrative	NOUN
admet-2988	4	8	review	review	NOUN
admet-2988	4	9	integrating	integrate	VERB
admet-2988	4	10	evidence	evidence	NOUN
admet-2988	4	11	on	on	ADP
admet-2988	4	12	bbb	bbb	PROPN
admet-2988	4	13	anatomy	anatomy	NOUN
admet-2988	4	14	,	,	PUNCT
admet-2988	4	15	transport	transport	NOUN
admet-2988	4	16	and	and	CCONJ
admet-2988	4	17	permeability	permeability	NOUN
admet-2988	4	18	mechanisms	mechanism	NOUN
admet-2988	4	19	,	,	PUNCT
admet-2988	4	20	drug	drug	NOUN
admet-2988	4	21	delivery	delivery	NOUN
admet-2988	4	22	optimization	optimization	NOUN
admet-2988	4	23	strategies	strategy	NOUN
admet-2988	4	24	,	,	PUNCT
admet-2988	4	25	with	with	ADP
admet-2988	4	26	a	a	DET
admet-2988	4	27	particular	particular	ADJ
admet-2988	4	28	focus	focus	NOUN
admet-2988	4	29	on	on	ADP
admet-2988	4	30	nanotechnology	nanotechnology	NOUN
admet-2988	4	31	-	-	PUNCT
admet-2988	4	32	based	base	VERB
admet-2988	4	33	systems	system	NOUN
admet-2988	4	34	,	,	PUNCT
admet-2988	4	35	and	and	CCONJ
admet-2988	4	36	preclinical	preclinical	ADJ
admet-2988	4	37	evaluation	evaluation	NOUN
admet-2988	4	38	models	model	NOUN
admet-2988	4	39	.	.	PUNCT
admet-2988	5	1	key	key	ADJ
admet-2988	5	2	results	result	NOUN
admet-2988	5	3	:	:	PUNCT
admet-2988	5	4	we	we	PRON
admet-2988	5	5	highlight	highlight	VERB
admet-2988	5	6	how	how	SCONJ
admet-2988	5	7	a	a	DET
admet-2988	5	8	deeper	deep	ADJ
admet-2988	5	9	understanding	understanding	NOUN
admet-2988	5	10	of	of	ADP
admet-2988	5	11	bbb	bbb	ADJ
admet-2988	5	12	architecture	architecture	NOUN
admet-2988	5	13	and	and	CCONJ
admet-2988	5	14	dynamic	dynamic	ADJ
admet-2988	5	15	regulation	regulation	NOUN
admet-2988	5	16	can	can	AUX
admet-2988	5	17	inform	inform	VERB
admet-2988	5	18	rational	rational	ADJ
admet-2988	5	19	design	design	NOUN
admet-2988	5	20	of	of	ADP
admet-2988	5	21	targeted	target	VERB
admet-2988	5	22	strategies	strategy	NOUN
admet-2988	5	23	.	.	PUNCT
admet-2988	6	1	drug	drug	NOUN
admet-2988	6	2	delivery	delivery	NOUN
admet-2988	6	3	approaches	approach	NOUN
admet-2988	6	4	are	be	AUX
admet-2988	6	5	summarized	summarize	VERB
admet-2988	6	6	and	and	CCONJ
admet-2988	6	7	compared	compare	VERB
admet-2988	6	8	,	,	PUNCT
admet-2988	6	9	with	with	SCONJ
admet-2988	6	10	emphasis	emphasis	NOUN
admet-2988	6	11	on	on	ADP
admet-2988	6	12	the	the	DET
admet-2988	6	13	potential	potential	NOUN
admet-2988	6	14	of	of	ADP
admet-2988	6	15	nanotechnology	nanotechnology	NOUN
admet-2988	6	16	-	-	PUNCT
admet-2988	6	17	based	base	VERB
admet-2988	6	18	platforms	platform	NOUN
admet-2988	6	19	to	to	PART
admet-2988	6	20	enhance	enhance	VERB
admet-2988	6	21	cns	cns	NOUN
admet-2988	6	22	drug	drug	NOUN
admet-2988	6	23	delivery	delivery	NOUN
admet-2988	6	24	.	.	PUNCT
admet-2988	7	1	translational	translational	ADJ
admet-2988	7	2	considerations	consideration	NOUN
admet-2988	7	3	,	,	PUNCT
admet-2988	7	4	including	include	VERB
admet-2988	7	5	scalability	scalability	NOUN
admet-2988	7	6	,	,	PUNCT
admet-2988	7	7	reproducibility	reproducibility	NOUN
admet-2988	7	8	,	,	PUNCT
admet-2988	7	9	and	and	CCONJ
admet-2988	7	10	regulatory	regulatory	ADJ
admet-2988	7	11	requirements	requirement	NOUN
admet-2988	7	12	,	,	PUNCT
admet-2988	7	13	are	be	AUX
admet-2988	7	14	critically	critically	ADV
admet-2988	7	15	addressed	address	VERB
admet-2988	7	16	.	.	PUNCT
admet-2988	8	1	major	major	ADJ
admet-2988	8	2	challenges	challenge	NOUN
admet-2988	8	3	identified	identify	VERB
admet-2988	8	4	include	include	VERB
admet-2988	8	5	receptor	receptor	NOUN
admet-2988	8	6	saturation	saturation	NOUN
admet-2988	8	7	,	,	PUNCT
admet-2988	8	8	competition	competition	NOUN
admet-2988	8	9	with	with	ADP
admet-2988	8	10	endogenous	endogenous	ADJ
admet-2988	8	11	ligands	ligand	NOUN
admet-2988	8	12	,	,	PUNCT
admet-2988	8	13	disease	disease	NOUN
admet-2988	8	14	-	-	PUNCT
admet-2988	8	15	specific	specific	ADJ
admet-2988	8	16	variability	variability	NOUN
admet-2988	8	17	in	in	ADP
admet-2988	8	18	bbb	bbb	PROPN
admet-2988	8	19	permeability	permeability	NOUN
admet-2988	8	20	,	,	PUNCT
admet-2988	8	21	and	and	CCONJ
admet-2988	8	22	the	the	DET
admet-2988	8	23	limited	limited	ADJ
admet-2988	8	24	predictive	predictive	ADJ
admet-2988	8	25	value	value	NOUN
admet-2988	8	26	of	of	ADP
admet-2988	8	27	current	current	ADJ
admet-2988	8	28	preclinical	preclinical	ADJ
admet-2988	8	29	models	model	NOUN
admet-2988	8	30	.	.	PUNCT
admet-2988	9	1	emerging	emerge	VERB
admet-2988	9	2	tools	tool	NOUN
admet-2988	9	3	,	,	PUNCT
admet-2988	9	4	such	such	ADJ
admet-2988	9	5	as	as	ADP
admet-2988	9	6	organ	organ	NOUN
admet-2988	9	7	-	-	PUNCT
admet-2988	9	8	on	on	ADP
admet-2988	9	9	-	-	PUNCT
admet-2988	9	10	chip	chip	NOUN
admet-2988	9	11	(	(	PUNCT
admet-2988	9	12	for	for	ADP
admet-2988	9	13	evaluation	evaluation	NOUN
admet-2988	9	14	)	)	PUNCT
admet-2988	9	15	and	and	CCONJ
admet-2988	9	16	microfluidic	microfluidic	ADJ
admet-2988	9	17	mixing	mixing	NOUN
admet-2988	9	18	(	(	PUNCT
admet-2988	9	19	for	for	ADP
admet-2988	9	20	manufacturing	manufacturing	NOUN
admet-2988	9	21	nanomaterials	nanomaterial	NOUN
admet-2988	9	22	)	)	PUNCT
admet-2988	9	23	,	,	PUNCT
admet-2988	9	24	offer	offer	VERB
admet-2988	9	25	promising	promise	VERB
admet-2988	9	26	means	mean	NOUN
admet-2988	9	27	to	to	PART
admet-2988	9	28	improve	improve	VERB
admet-2988	9	29	physiological	physiological	ADJ
admet-2988	9	30	relevance	relevance	NOUN
admet-2988	9	31	and	and	CCONJ
admet-2988	9	32	accelerate	accelerate	VERB
admet-2988	9	33	translation	translation	NOUN
admet-2988	9	34	.	.	PUNCT
admet-2988	10	1	conclusion	conclusion	NOUN
admet-2988	10	2	:	:	PUNCT
admet-2988	10	3	progress	progress	NOUN
admet-2988	10	4	in	in	ADP
admet-2988	10	5	bbb	bbb	PROPN
admet-2988	10	6	research	research	NOUN
admet-2988	10	7	has	have	AUX
admet-2988	10	8	laid	lay	VERB
admet-2988	10	9	the	the	DET
admet-2988	10	10	groundwork	groundwork	NOUN
admet-2988	10	11	for	for	ADP
admet-2988	10	12	innovative	innovative	ADJ
admet-2988	10	13	therapies	therapy	NOUN
admet-2988	10	14	,	,	PUNCT
admet-2988	10	15	but	but	CCONJ
admet-2988	10	16	significant	significant	ADJ
admet-2988	10	17	hurdles	hurdle	NOUN
admet-2988	10	18	remain	remain	VERB
admet-2988	10	19	.	.	PUNCT
admet-2988	11	1	advancing	advance	VERB
admet-2988	11	2	cns	cns	NOUN
admet-2988	11	3	drug	drug	NOUN
admet-2988	11	4	delivery	delivery	NOUN
admet-2988	11	5	will	will	AUX
admet-2988	11	6	require	require	VERB
admet-2988	11	7	collaborative	collaborative	ADJ
admet-2988	11	8	work	work	NOUN
admet-2988	11	9	refining	refining	NOUN
admet-2988	11	10	transport	transport	NOUN
admet-2988	11	11	-	-	PUNCT
admet-2988	11	12	targeting	target	VERB
admet-2988	11	13	mechanisms	mechanism	NOUN
admet-2988	11	14	,	,	PUNCT
admet-2988	11	15	developing	develop	VERB
admet-2988	11	16	standardized	standardized	ADJ
admet-2988	11	17	preclinical	preclinical	ADJ
admet-2988	11	18	models	model	NOUN
admet-2988	11	19	,	,	PUNCT
admet-2988	11	20	and	and	CCONJ
admet-2988	11	21	integrating	integrate	VERB
admet-2988	11	22	fundamental	fundamental	ADJ
admet-2988	11	23	research	research	NOUN
admet-2988	11	24	,	,	PUNCT
admet-2988	11	25	applied	apply	VERB
admet-2988	11	26	nanomedicine	nanomedicine	NOUN
admet-2988	11	27	,	,	PUNCT
admet-2988	11	28	and	and	CCONJ
admet-2988	11	29	regulatory	regulatory	ADJ
admet-2988	11	30	science	science	NOUN
admet-2988	11	31	to	to	PART
admet-2988	11	32	open	open	VERB
admet-2988	11	33	new	new	ADJ
admet-2988	11	34	opportunities	opportunity	NOUN
admet-2988	11	35	for	for	ADP
admet-2988	11	36	treating	treat	VERB
admet-2988	11	37	neurological	neurological	ADJ
admet-2988	11	38	and	and	CCONJ
admet-2988	11	39	psychiatric	psychiatric	ADJ
admet-2988	11	40	disorders	disorder	NOUN
admet-2988	11	41	and	and	CCONJ
admet-2988	11	42	brain	brain	NOUN
admet-2988	11	43	tumours	tumour	NOUN
admet-2988	11	44	.	.	PUNCT
admet-2988	12	1	©	©	PROPN
admet-2988	12	2	2025	2025	NUM
admet-2988	12	3	by	by	ADP
admet-2988	12	4	the	the	DET
admet-2988	12	5	authors	author	NOUN
admet-2988	12	6	.	.	PUNCT
admet-2988	13	1	this	this	DET
admet-2988	13	2	article	article	NOUN
admet-2988	13	3	is	be	AUX
admet-2988	13	4	an	an	DET
admet-2988	13	5	open	open	ADJ
admet-2988	13	6	-	-	PUNCT
admet-2988	13	7	access	access	NOUN
admet-2988	13	8	article	article	NOUN
admet-2988	13	9	distributed	distribute	VERB
admet-2988	13	10	under	under	ADP
admet-2988	13	11	the	the	DET
admet-2988	13	12	terms	term	NOUN
admet-2988	13	13	and	and	CCONJ
admet-2988	13	14	conditions	condition	NOUN
admet-2988	13	15	of	of	ADP
admet-2988	13	16	the	the	DET
admet-2988	13	17	creative	creative	ADJ
admet-2988	13	18	commons	common	NOUN
admet-2988	13	19	attribution	attribution	NOUN
admet-2988	13	20	license	license	NOUN
admet-2988	13	21	(	(	PUNCT
admet-2988	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2988	13	23	)	)	PUNCT
admet-2988	13	24	.	.	PUNCT
admet-2988	14	1	keywords	keyword	VERB
admet-2988	14	2	brain	brain	NOUN
admet-2988	14	3	delivery	delivery	NOUN
admet-2988	14	4	;	;	PUNCT
admet-2988	14	5	central	central	ADJ
admet-2988	14	6	nervous	nervous	ADJ
admet-2988	14	7	system	system	NOUN
admet-2988	14	8	;	;	PUNCT
admet-2988	14	9	targeted	target	VERB
admet-2988	14	10	therapy	therapy	NOUN
admet-2988	14	11	;	;	PUNCT
admet-2988	14	12	lipid	lipid	NOUN
admet-2988	14	13	nanoparticles	nanoparticle	VERB
admet-2988	14	14	http://doi.org/10.5599/admet.2988	http://doi.org/10.5599/admet.2988	NOUN
admet-2988	14	15	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	ADJ
admet-2988	14	16	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	http://www.pub.iapchem.org/ojs/index.ph-p/admet/index	NOUN
admet-2988	14	17	mailto:ronny.vargas_m@ucr.ac.cr	mailto:ronny.vargas_m@ucr.ac.cr	PROPN
admet-2988	14	18	mailto:csune@ipb.csic.es	mailto:csune@ipb.csic.es	PROPN
admet-2988	14	19	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-2988	14	20	r.	r.	PROPN
admet-2988	14	21	vargas	vargas	PROPN
admet-2988	14	22	et	et	PROPN
admet-2988	14	23	al	al	PROPN
admet-2988	14	24	.	.	PROPN
admet-2988	14	25	admet	admet	PROPN
admet-2988	14	26	&	&	CCONJ
admet-2988	14	27	dmpk	dmpk	PROPN
admet-2988	14	28	13(5	13(5	NUM
admet-2988	14	29	)	)	PUNCT
admet-2988	14	30	(	(	PUNCT
admet-2988	14	31	2025	2025	NUM
admet-2988	14	32	)	)	PUNCT
admet-2988	14	33	2988	2988	NUM
admet-2988	14	34	2	2	NUM
admet-2988	14	35	introduction	introduction	NOUN
admet-2988	14	36	over	over	ADP
admet-2988	14	37	a	a	DET
admet-2988	14	38	period	period	NOUN
admet-2988	14	39	of	of	ADP
admet-2988	14	40	more	more	ADJ
admet-2988	14	41	than	than	ADP
admet-2988	14	42	580	580	NUM
admet-2988	14	43	million	million	NUM
admet-2988	14	44	years	year	NOUN
admet-2988	14	45	,	,	PUNCT
admet-2988	14	46	the	the	DET
admet-2988	14	47	central	central	ADJ
admet-2988	14	48	nervous	nervous	ADJ
admet-2988	14	49	system	system	NOUN
admet-2988	14	50	(	(	PUNCT
admet-2988	14	51	cns	cns	NOUN
admet-2988	14	52	)	)	PUNCT
admet-2988	14	53	has	have	AUX
admet-2988	14	54	evolved	evolve	VERB
admet-2988	14	55	through	through	ADP
admet-2988	14	56	cellular	cellular	ADJ
admet-2988	14	57	diversification	diversification	NOUN
admet-2988	14	58	,	,	PUNCT
admet-2988	14	59	specialization	specialization	NOUN
admet-2988	14	60	,	,	PUNCT
admet-2988	14	61	and	and	CCONJ
admet-2988	14	62	functional	functional	ADJ
admet-2988	14	63	compartmentalization	compartmentalization	NOUN
admet-2988	15	1	[	[	X
admet-2988	15	2	1	1	NUM
admet-2988	15	3	-	-	SYM
admet-2988	15	4	3	3	NUM
admet-2988	15	5	]	]	PUNCT
admet-2988	15	6	.	.	PUNCT
admet-2988	16	1	it	it	PRON
admet-2988	16	2	has	have	AUX
admet-2988	16	3	been	be	AUX
admet-2988	16	4	theorized	theorize	VERB
admet-2988	16	5	that	that	SCONJ
admet-2988	16	6	the	the	DET
admet-2988	16	7	emergence	emergence	NOUN
admet-2988	16	8	of	of	ADP
admet-2988	16	9	a	a	DET
admet-2988	16	10	more	more	ADV
admet-2988	16	11	complex	complex	ADJ
admet-2988	16	12	cns	cns	NOUN
admet-2988	16	13	led	lead	VERB
admet-2988	16	14	to	to	ADP
admet-2988	16	15	the	the	DET
admet-2988	16	16	formation	formation	NOUN
admet-2988	16	17	of	of	ADP
admet-2988	16	18	tissue	tissue	NOUN
admet-2988	16	19	bundles	bundle	NOUN
admet-2988	16	20	that	that	PRON
admet-2988	16	21	regulate	regulate	VERB
admet-2988	16	22	the	the	DET
admet-2988	16	23	exchange	exchange	NOUN
admet-2988	16	24	of	of	ADP
admet-2988	16	25	substances	substance	NOUN
admet-2988	16	26	between	between	ADP
admet-2988	16	27	the	the	DET
admet-2988	16	28	brain	brain	NOUN
admet-2988	16	29	and	and	CCONJ
admet-2988	16	30	the	the	DET
admet-2988	16	31	bloodstream	bloodstream	NOUN
admet-2988	16	32	,	,	PUNCT
admet-2988	16	33	thereby	thereby	ADV
admet-2988	16	34	protecting	protect	VERB
admet-2988	16	35	brain	brain	NOUN
admet-2988	16	36	tissue	tissue	NOUN
admet-2988	16	37	from	from	ADP
admet-2988	16	38	harmful	harmful	ADJ
admet-2988	16	39	agents	agent	NOUN
admet-2988	16	40	[	[	X
admet-2988	16	41	4	4	NUM
admet-2988	16	42	]	]	PUNCT
admet-2988	16	43	.	.	PUNCT
admet-2988	17	1	this	this	DET
admet-2988	17	2	critical	critical	ADJ
admet-2988	17	3	tissue	tissue	NOUN
admet-2988	17	4	for	for	ADP
admet-2988	17	5	maintaining	maintain	VERB
admet-2988	17	6	brain	brain	NOUN
admet-2988	17	7	homeostasis	homeostasis	NOUN
admet-2988	17	8	is	be	AUX
admet-2988	17	9	known	know	VERB
admet-2988	17	10	as	as	ADP
admet-2988	17	11	the	the	DET
admet-2988	17	12	blood	blood	NOUN
admet-2988	17	13	-	-	PUNCT
admet-2988	17	14	brain	brain	NOUN
admet-2988	17	15	barrier	barrier	NOUN
admet-2988	17	16	(	(	PUNCT
admet-2988	17	17	bbb	bbb	NOUN
admet-2988	17	18	)	)	PUNCT
admet-2988	18	1	[	[	X
admet-2988	18	2	5,6	5,6	NUM
admet-2988	18	3	]	]	X
admet-2988	18	4	.	.	PUNCT
admet-2988	19	1	the	the	DET
admet-2988	19	2	bbb	bbb	PROPN
admet-2988	19	3	is	be	AUX
admet-2988	19	4	present	present	ADJ
admet-2988	19	5	in	in	ADP
admet-2988	19	6	all	all	DET
admet-2988	19	7	vertebrates	vertebrate	NOUN
admet-2988	19	8	and	and	CCONJ
admet-2988	19	9	,	,	PUNCT
admet-2988	19	10	in	in	ADP
admet-2988	19	11	more	more	ADV
admet-2988	19	12	primitive	primitive	ADJ
admet-2988	19	13	forms	form	NOUN
admet-2988	19	14	,	,	PUNCT
admet-2988	19	15	in	in	ADP
admet-2988	19	16	some	some	DET
admet-2988	19	17	invertebrates	invertebrate	NOUN
admet-2988	19	18	[	[	X
admet-2988	19	19	7,8	7,8	NUM
admet-2988	19	20	]	]	PUNCT
admet-2988	19	21	.	.	PUNCT
admet-2988	20	1	while	while	SCONJ
admet-2988	20	2	less	less	ADJ
admet-2988	20	3	complex	complex	ADJ
admet-2988	20	4	organisms	organism	NOUN
admet-2988	20	5	have	have	VERB
admet-2988	20	6	simple	simple	ADJ
admet-2988	20	7	barrier	barrier	NOUN
admet-2988	20	8	structures	structure	NOUN
admet-2988	20	9	,	,	PUNCT
admet-2988	20	10	higher	high	ADJ
admet-2988	20	11	primates	primate	NOUN
admet-2988	20	12	,	,	PUNCT
admet-2988	20	13	especially	especially	ADV
admet-2988	20	14	humans	human	NOUN
admet-2988	20	15	,	,	PUNCT
admet-2988	20	16	have	have	AUX
admet-2988	20	17	developed	develop	VERB
admet-2988	20	18	a	a	DET
admet-2988	20	19	highly	highly	ADV
admet-2988	20	20	sophisticated	sophisticated	ADJ
admet-2988	20	21	bbb	bbb	NOUN
admet-2988	20	22	composed	compose	VERB
admet-2988	20	23	of	of	ADP
admet-2988	20	24	various	various	ADJ
admet-2988	20	25	specialised	specialised	ADJ
admet-2988	20	26	cell	cell	NOUN
admet-2988	20	27	types	type	NOUN
admet-2988	20	28	and	and	CCONJ
admet-2988	20	29	extracellular	extracellular	ADJ
admet-2988	20	30	matrix	matrix	NOUN
admet-2988	20	31	components	component	NOUN
admet-2988	20	32	[	[	X
admet-2988	20	33	9,10	9,10	NUM
admet-2988	20	34	]	]	X
admet-2988	20	35	.	.	PUNCT
admet-2988	21	1	its	its	PRON
admet-2988	21	2	low	low	ADJ
admet-2988	21	3	permeability	permeability	NOUN
admet-2988	21	4	to	to	ADP
admet-2988	21	5	foreign	foreign	ADJ
admet-2988	21	6	substances	substance	NOUN
admet-2988	21	7	,	,	PUNCT
admet-2988	21	8	conserved	conserve	VERB
admet-2988	21	9	throughout	throughout	ADP
admet-2988	21	10	evolution	evolution	NOUN
admet-2988	21	11	,	,	PUNCT
admet-2988	21	12	is	be	AUX
admet-2988	21	13	an	an	DET
admet-2988	21	14	evolutionary	evolutionary	ADJ
admet-2988	21	15	advantage	advantage	NOUN
admet-2988	21	16	and	and	CCONJ
admet-2988	21	17	a	a	DET
admet-2988	21	18	key	key	ADJ
admet-2988	21	19	feature	feature	NOUN
admet-2988	21	20	that	that	PRON
admet-2988	21	21	is	be	AUX
admet-2988	21	22	established	establish	VERB
admet-2988	21	23	during	during	ADP
admet-2988	21	24	the	the	DET
admet-2988	21	25	early	early	ADJ
admet-2988	21	26	stages	stage	NOUN
admet-2988	21	27	of	of	ADP
admet-2988	21	28	embryonic	embryonic	ADJ
admet-2988	21	29	development	development	NOUN
admet-2988	21	30	[	[	X
admet-2988	21	31	7,11,12	7,11,12	NUM
admet-2988	21	32	]	]	PUNCT
admet-2988	21	33	.	.	PUNCT
admet-2988	22	1	the	the	DET
admet-2988	22	2	concept	concept	NOUN
admet-2988	22	3	of	of	ADP
admet-2988	22	4	the	the	DET
admet-2988	22	5	bbb	bbb	PROPN
admet-2988	22	6	originated	originate	VERB
admet-2988	22	7	in	in	ADP
admet-2988	22	8	the	the	DET
admet-2988	22	9	late	late	ADJ
admet-2988	22	10	19th	19th	ADJ
admet-2988	22	11	century	century	NOUN
admet-2988	22	12	,	,	PUNCT
admet-2988	22	13	when	when	SCONJ
admet-2988	22	14	paul	paul	PROPN
admet-2988	22	15	ehrlich	ehrlich	PROPN
admet-2988	22	16	observed	observe	VERB
admet-2988	22	17	that	that	SCONJ
admet-2988	22	18	systemically	systemically	ADV
admet-2988	22	19	administered	administer	VERB
admet-2988	22	20	dyes	dye	NOUN
admet-2988	22	21	failed	fail	VERB
admet-2988	22	22	to	to	PART
admet-2988	22	23	stain	stain	VERB
admet-2988	22	24	the	the	DET
admet-2988	22	25	brain	brain	NOUN
admet-2988	22	26	,	,	PUNCT
admet-2988	22	27	unlike	unlike	ADP
admet-2988	22	28	other	other	ADJ
admet-2988	22	29	organs	organ	NOUN
admet-2988	22	30	[	[	X
admet-2988	22	31	13,14	13,14	NUM
admet-2988	22	32	]	]	PUNCT
admet-2988	22	33	.	.	PUNCT
admet-2988	23	1	however	however	ADV
admet-2988	23	2	,	,	PUNCT
admet-2988	23	3	he	he	PRON
admet-2988	23	4	explained	explain	VERB
admet-2988	23	5	this	this	DET
admet-2988	23	6	finding	finding	NOUN
admet-2988	23	7	in	in	ADP
admet-2988	23	8	terms	term	NOUN
admet-2988	23	9	of	of	ADP
admet-2988	23	10	differences	difference	NOUN
admet-2988	23	11	in	in	ADP
admet-2988	23	12	tissue	tissue	NOUN
admet-2988	23	13	affinity	affinity	NOUN
admet-2988	23	14	rather	rather	ADV
admet-2988	23	15	than	than	ADP
admet-2988	23	16	the	the	DET
admet-2988	23	17	presence	presence	NOUN
admet-2988	23	18	of	of	ADP
admet-2988	23	19	a	a	DET
admet-2988	23	20	physical	physical	ADJ
admet-2988	23	21	barrier	barrier	NOUN
admet-2988	23	22	[	[	X
admet-2988	23	23	12	12	NUM
admet-2988	23	24	]	]	PUNCT
admet-2988	23	25	.	.	PUNCT
admet-2988	24	1	this	this	DET
admet-2988	24	2	interpretation	interpretation	NOUN
admet-2988	24	3	was	be	AUX
admet-2988	24	4	later	later	ADV
admet-2988	24	5	challenged	challenge	VERB
admet-2988	24	6	by	by	ADP
admet-2988	24	7	edwin	edwin	PROPN
admet-2988	24	8	goldman	goldman	PROPN
admet-2988	24	9	,	,	PUNCT
admet-2988	24	10	who	who	PRON
admet-2988	24	11	demonstrated	demonstrate	VERB
admet-2988	24	12	that	that	SCONJ
admet-2988	24	13	dyes	dye	NOUN
admet-2988	24	14	which	which	PRON
admet-2988	24	15	did	do	AUX
admet-2988	24	16	not	not	PART
admet-2988	24	17	stain	stain	VERB
admet-2988	24	18	the	the	DET
admet-2988	24	19	brain	brain	NOUN
admet-2988	24	20	via	via	ADP
admet-2988	24	21	systemic	systemic	ADJ
admet-2988	24	22	administration	administration	NOUN
admet-2988	24	23	did	do	VERB
admet-2988	24	24	so	so	ADV
admet-2988	24	25	when	when	SCONJ
admet-2988	24	26	injected	inject	VERB
admet-2988	24	27	directly	directly	ADV
admet-2988	24	28	into	into	ADP
admet-2988	24	29	brain	brain	NOUN
admet-2988	24	30	tissue	tissue	NOUN
admet-2988	24	31	,	,	PUNCT
admet-2988	24	32	providing	provide	VERB
admet-2988	24	33	clear	clear	ADJ
admet-2988	24	34	evidence	evidence	NOUN
admet-2988	24	35	for	for	ADP
admet-2988	24	36	a	a	DET
admet-2988	24	37	selective	selective	ADJ
admet-2988	24	38	physical	physical	ADJ
admet-2988	24	39	barrier	barrier	NOUN
admet-2988	24	40	[	[	X
admet-2988	24	41	14	14	NUM
admet-2988	24	42	]	]	PUNCT
admet-2988	24	43	.	.	PUNCT
admet-2988	25	1	max	max	PROPN
admet-2988	25	2	lewandowsky	lewandowsky	PROPN
admet-2988	25	3	further	far	ADV
admet-2988	25	4	supported	support	VERB
admet-2988	25	5	the	the	DET
admet-2988	25	6	existence	existence	NOUN
admet-2988	25	7	of	of	ADP
admet-2988	25	8	a	a	DET
admet-2988	25	9	barrier	barrier	NOUN
admet-2988	25	10	by	by	ADP
admet-2988	25	11	showing	show	VERB
admet-2988	25	12	that	that	SCONJ
admet-2988	25	13	neurotoxins	neurotoxin	NOUN
admet-2988	25	14	had	have	VERB
admet-2988	25	15	stronger	strong	ADJ
admet-2988	25	16	effects	effect	NOUN
admet-2988	25	17	when	when	SCONJ
admet-2988	25	18	administered	administer	VERB
admet-2988	25	19	intracerebrally	intracerebrally	ADV
admet-2988	25	20	compared	compare	VERB
admet-2988	25	21	to	to	ADP
admet-2988	25	22	systemic	systemic	ADJ
admet-2988	25	23	routes	route	NOUN
admet-2988	25	24	,	,	PUNCT
admet-2988	25	25	thus	thus	ADV
admet-2988	25	26	reinforcing	reinforce	VERB
admet-2988	25	27	the	the	DET
admet-2988	25	28	concept	concept	NOUN
admet-2988	25	29	of	of	ADP
admet-2988	25	30	a	a	DET
admet-2988	25	31	functional	functional	ADJ
admet-2988	25	32	barrier	barrier	NOUN
admet-2988	25	33	[	[	X
admet-2988	25	34	14	14	NUM
admet-2988	25	35	]	]	PUNCT
admet-2988	25	36	.	.	PUNCT
admet-2988	26	1	the	the	DET
admet-2988	26	2	term	term	NOUN
admet-2988	26	3	bbb	bbb	PROPN
admet-2988	26	4	was	be	AUX
admet-2988	26	5	formalized	formalize	VERB
admet-2988	26	6	through	through	ADP
admet-2988	26	7	the	the	DET
admet-2988	26	8	work	work	NOUN
admet-2988	26	9	of	of	ADP
admet-2988	26	10	lisa	lisa	PROPN
admet-2988	26	11	stern	stern	NOUN
admet-2988	26	12	and	and	CCONJ
admet-2988	26	13	colleagues	colleague	NOUN
admet-2988	26	14	,	,	PUNCT
admet-2988	26	15	who	who	PRON
admet-2988	26	16	identified	identify	VERB
admet-2988	26	17	the	the	DET
admet-2988	26	18	dual	dual	ADJ
admet-2988	26	19	role	role	NOUN
admet-2988	26	20	of	of	ADP
admet-2988	26	21	brain	brain	NOUN
admet-2988	26	22	endothelial	endothelial	ADJ
admet-2988	26	23	cells	cell	NOUN
admet-2988	26	24	(	(	PUNCT
admet-2988	26	25	ecs	ec	NOUN
admet-2988	26	26	)	)	PUNCT
admet-2988	26	27	in	in	ADP
admet-2988	26	28	both	both	CCONJ
admet-2988	26	29	protecting	protect	VERB
admet-2988	26	30	and	and	CCONJ
admet-2988	26	31	metabolically	metabolically	ADV
admet-2988	26	32	supporting	support	VERB
admet-2988	26	33	the	the	DET
admet-2988	26	34	cns	cns	NOUN
admet-2988	26	35	[	[	X
admet-2988	26	36	15	15	NUM
admet-2988	26	37	]	]	PUNCT
admet-2988	26	38	.	.	PUNCT
admet-2988	27	1	the	the	DET
admet-2988	27	2	development	development	NOUN
admet-2988	27	3	of	of	ADP
admet-2988	27	4	electron	electron	NOUN
admet-2988	27	5	microscopy	microscopy	NOUN
admet-2988	27	6	in	in	ADP
admet-2988	27	7	the	the	DET
admet-2988	27	8	20th	20th	ADJ
admet-2988	27	9	century	century	NOUN
admet-2988	27	10	enabled	enable	VERB
admet-2988	27	11	the	the	DET
admet-2988	27	12	precise	precise	ADJ
admet-2988	27	13	localization	localization	NOUN
admet-2988	27	14	of	of	ADP
admet-2988	27	15	the	the	DET
admet-2988	27	16	bbb	bbb	PROPN
admet-2988	27	17	to	to	ADP
admet-2988	27	18	the	the	DET
admet-2988	27	19	ecs	ecs	PROPN
admet-2988	27	20	of	of	ADP
admet-2988	27	21	brain	brain	NOUN
admet-2988	27	22	capillaries	capillary	NOUN
admet-2988	27	23	and	and	CCONJ
admet-2988	27	24	allowed	allow	VERB
admet-2988	27	25	for	for	ADP
admet-2988	27	26	detailed	detailed	ADJ
admet-2988	27	27	characterization	characterization	NOUN
admet-2988	27	28	of	of	ADP
admet-2988	27	29	their	their	PRON
admet-2988	27	30	structure	structure	NOUN
admet-2988	27	31	[	[	X
admet-2988	27	32	15,16	15,16	NUM
admet-2988	27	33	]	]	PUNCT
admet-2988	27	34	.	.	PUNCT
admet-2988	28	1	this	this	DET
admet-2988	28	2	technological	technological	ADJ
admet-2988	28	3	breakthrough	breakthrough	NOUN
admet-2988	28	4	significantly	significantly	ADV
admet-2988	28	5	advanced	advance	VERB
admet-2988	28	6	the	the	DET
admet-2988	28	7	understanding	understanding	NOUN
admet-2988	28	8	of	of	ADP
admet-2988	28	9	the	the	DET
admet-2988	28	10	bbb	bbb	PROPN
admet-2988	28	11	’s	’s	PART
admet-2988	28	12	functional	functional	ADJ
admet-2988	28	13	anatomy	anatomy	NOUN
admet-2988	28	14	,	,	PUNCT
admet-2988	28	15	including	include	VERB
admet-2988	28	16	intercellular	intercellular	ADJ
admet-2988	28	17	junctions	junction	NOUN
admet-2988	28	18	,	,	PUNCT
admet-2988	28	19	communication	communication	NOUN
admet-2988	28	20	pathways	pathway	NOUN
admet-2988	28	21	,	,	PUNCT
admet-2988	28	22	and	and	CCONJ
admet-2988	28	23	transport	transport	NOUN
admet-2988	28	24	mechanisms	mechanism	NOUN
admet-2988	28	25	that	that	PRON
admet-2988	28	26	regulate	regulate	VERB
admet-2988	28	27	cns	cns	NOUN
admet-2988	28	28	homeostasis	homeostasis	NOUN
admet-2988	28	29	[	[	X
admet-2988	28	30	6	6	NUM
admet-2988	28	31	]	]	PUNCT
admet-2988	28	32	.	.	PUNCT
admet-2988	29	1	progress	progress	NOUN
admet-2988	29	2	in	in	ADP
admet-2988	29	3	this	this	DET
admet-2988	29	4	field	field	NOUN
admet-2988	29	5	led	lead	VERB
admet-2988	29	6	to	to	ADP
admet-2988	29	7	the	the	DET
admet-2988	29	8	adoption	adoption	NOUN
admet-2988	29	9	of	of	ADP
admet-2988	29	10	the	the	DET
admet-2988	29	11	neurovascular	neurovascular	ADJ
admet-2988	29	12	unit	unit	NOUN
admet-2988	29	13	(	(	PUNCT
admet-2988	29	14	nvu	nvu	NOUN
admet-2988	29	15	)	)	PUNCT
admet-2988	29	16	concept	concept	NOUN
admet-2988	29	17	in	in	ADP
admet-2988	29	18	the	the	DET
admet-2988	29	19	early	early	ADJ
admet-2988	29	20	2000s	2000	NOUN
admet-2988	29	21	[	[	X
admet-2988	29	22	10,17	10,17	NUM
admet-2988	29	23	]	]	PUNCT
admet-2988	29	24	,	,	PUNCT
admet-2988	29	25	providing	provide	VERB
admet-2988	29	26	a	a	DET
admet-2988	29	27	broader	broad	ADJ
admet-2988	29	28	framework	framework	NOUN
admet-2988	29	29	for	for	ADP
admet-2988	29	30	understanding	understand	VERB
admet-2988	29	31	the	the	DET
admet-2988	29	32	interplay	interplay	NOUN
admet-2988	29	33	among	among	ADP
admet-2988	29	34	the	the	DET
admet-2988	29	35	components	component	NOUN
admet-2988	29	36	involved	involve	VERB
admet-2988	29	37	in	in	ADP
admet-2988	29	38	bbb	bbb	PROPN
admet-2988	29	39	regulation	regulation	NOUN
admet-2988	29	40	[	[	X
admet-2988	29	41	18	18	NUM
admet-2988	29	42	]	]	PUNCT
admet-2988	29	43	.	.	PUNCT
admet-2988	30	1	figure	figure	NOUN
admet-2988	30	2	1	1	NUM
admet-2988	30	3	illustrates	illustrate	VERB
admet-2988	30	4	how	how	SCONJ
admet-2988	30	5	the	the	DET
admet-2988	30	6	integration	integration	NOUN
admet-2988	30	7	of	of	ADP
admet-2988	30	8	a	a	DET
admet-2988	30	9	growing	grow	VERB
admet-2988	30	10	body	body	NOUN
admet-2988	30	11	of	of	ADP
admet-2988	30	12	knowledge	knowledge	NOUN
admet-2988	30	13	has	have	AUX
admet-2988	30	14	improved	improve	VERB
admet-2988	30	15	our	our	PRON
admet-2988	30	16	understanding	understanding	NOUN
admet-2988	30	17	of	of	ADP
admet-2988	30	18	bbb	bbb	PROPN
admet-2988	30	19	physiology	physiology	NOUN
admet-2988	30	20	.	.	PUNCT
admet-2988	31	1	however	however	ADV
admet-2988	31	2	,	,	PUNCT
admet-2988	31	3	further	further	ADJ
admet-2988	31	4	research	research	NOUN
admet-2988	31	5	and	and	CCONJ
admet-2988	31	6	a	a	DET
admet-2988	31	7	deeper	deep	ADJ
admet-2988	31	8	understanding	understanding	NOUN
admet-2988	31	9	of	of	ADP
admet-2988	31	10	the	the	DET
admet-2988	31	11	bbb	bbb	PROPN
admet-2988	31	12	’s	’s	PART
admet-2988	31	13	composition	composition	NOUN
admet-2988	31	14	are	be	AUX
admet-2988	31	15	needed	need	VERB
admet-2988	31	16	to	to	PART
admet-2988	31	17	develop	develop	VERB
admet-2988	31	18	effective	effective	ADJ
admet-2988	31	19	strategies	strategy	NOUN
admet-2988	31	20	to	to	PART
admet-2988	31	21	overcome	overcome	VERB
admet-2988	31	22	bbb	bbb	PROPN
admet-2988	31	23	permeability	permeability	NOUN
admet-2988	31	24	,	,	PUNCT
admet-2988	31	25	which	which	PRON
admet-2988	31	26	remains	remain	VERB
admet-2988	31	27	a	a	DET
admet-2988	31	28	major	major	ADJ
admet-2988	31	29	challenge	challenge	NOUN
admet-2988	31	30	to	to	ADP
admet-2988	31	31	optimizing	optimize	VERB
admet-2988	31	32	therapies	therapy	NOUN
admet-2988	31	33	for	for	ADP
admet-2988	31	34	neurological	neurological	ADJ
admet-2988	31	35	diseases	disease	NOUN
admet-2988	31	36	[	[	X
admet-2988	31	37	19	19	NUM
admet-2988	31	38	]	]	PUNCT
admet-2988	31	39	.	.	PUNCT
admet-2988	32	1	blood	blood	NOUN
admet-2988	32	2	-	-	PUNCT
admet-2988	32	3	brain	brain	NOUN
admet-2988	32	4	barrier	barrier	NOUN
admet-2988	32	5	composition	composition	NOUN
admet-2988	32	6	the	the	DET
admet-2988	32	7	selective	selective	ADJ
admet-2988	32	8	permeability	permeability	NOUN
admet-2988	32	9	of	of	ADP
admet-2988	32	10	the	the	DET
admet-2988	32	11	bbb	bbb	PROPN
admet-2988	32	12	is	be	AUX
admet-2988	32	13	essential	essential	ADJ
admet-2988	32	14	for	for	ADP
admet-2988	32	15	maintaining	maintain	VERB
admet-2988	32	16	brain	brain	NOUN
admet-2988	32	17	homeostasis	homeostasis	NOUN
admet-2988	32	18	,	,	PUNCT
admet-2988	32	19	allowing	allow	VERB
admet-2988	32	20	the	the	DET
admet-2988	32	21	passage	passage	NOUN
admet-2988	32	22	of	of	ADP
admet-2988	32	23	oxygen	oxygen	NOUN
admet-2988	32	24	and	and	CCONJ
admet-2988	32	25	nutrients	nutrient	NOUN
admet-2988	32	26	while	while	SCONJ
admet-2988	32	27	restricting	restrict	VERB
admet-2988	32	28	the	the	DET
admet-2988	32	29	entry	entry	NOUN
admet-2988	32	30	of	of	ADP
admet-2988	32	31	toxins	toxin	NOUN
admet-2988	32	32	and	and	CCONJ
admet-2988	32	33	pathogens	pathogen	NOUN
admet-2988	32	34	[	[	X
admet-2988	32	35	20,21	20,21	NUM
admet-2988	32	36	]	]	PUNCT
admet-2988	32	37	.	.	PUNCT
admet-2988	33	1	this	this	DET
admet-2988	33	2	unique	unique	ADJ
admet-2988	33	3	property	property	NOUN
admet-2988	33	4	arises	arise	VERB
admet-2988	33	5	from	from	ADP
admet-2988	33	6	the	the	DET
admet-2988	33	7	complex	complex	ADJ
admet-2988	33	8	organization	organization	NOUN
admet-2988	33	9	of	of	ADP
admet-2988	33	10	the	the	DET
admet-2988	33	11	nvu	nvu	NOUN
admet-2988	34	1	[	[	X
admet-2988	34	2	10,17,18	10,17,18	NUM
admet-2988	34	3	]	]	PUNCT
admet-2988	34	4	,	,	PUNCT
admet-2988	34	5	which	which	PRON
admet-2988	34	6	encompasses	encompass	VERB
admet-2988	34	7	both	both	CCONJ
admet-2988	34	8	the	the	DET
admet-2988	34	9	anatomical	anatomical	ADJ
admet-2988	34	10	and	and	CCONJ
admet-2988	34	11	functional	functional	ADJ
admet-2988	34	12	components	component	NOUN
admet-2988	34	13	of	of	ADP
admet-2988	34	14	the	the	DET
admet-2988	34	15	bbb	bbb	PROPN
admet-2988	34	16	(	(	PUNCT
admet-2988	34	17	figure	figure	NOUN
admet-2988	34	18	2	2	NUM
admet-2988	34	19	)	)	PUNCT
admet-2988	34	20	.	.	PUNCT
admet-2988	35	1	the	the	DET
admet-2988	35	2	nvu	nvu	NOUN
admet-2988	35	3	is	be	AUX
admet-2988	35	4	composed	compose	VERB
admet-2988	35	5	of	of	ADP
admet-2988	35	6	ecs	ecs	PROPN
admet-2988	35	7	,	,	PUNCT
admet-2988	35	8	pericytes	pericyte	NOUN
admet-2988	35	9	,	,	PUNCT
admet-2988	35	10	astrocytes	astrocyte	NOUN
admet-2988	35	11	,	,	PUNCT
admet-2988	35	12	neurons	neuron	NOUN
admet-2988	35	13	,	,	PUNCT
admet-2988	35	14	myocytes	myocyte	NOUN
admet-2988	35	15	,	,	PUNCT
admet-2988	35	16	and	and	CCONJ
admet-2988	35	17	the	the	DET
admet-2988	35	18	extracellular	extracellular	ADJ
admet-2988	35	19	matrix	matrix	NOUN
admet-2988	35	20	,	,	PUNCT
admet-2988	35	21	all	all	PRON
admet-2988	35	22	of	of	ADP
admet-2988	35	23	which	which	PRON
admet-2988	35	24	dynamically	dynamically	ADV
admet-2988	35	25	regulate	regulate	VERB
admet-2988	35	26	the	the	DET
admet-2988	35	27	interactions	interaction	NOUN
admet-2988	35	28	between	between	ADP
admet-2988	35	29	the	the	DET
admet-2988	35	30	brain	brain	NOUN
admet-2988	35	31	and	and	CCONJ
admet-2988	35	32	the	the	DET
admet-2988	35	33	systemic	systemic	ADJ
admet-2988	35	34	circulation	circulation	NOUN
admet-2988	35	35	.	.	PUNCT
admet-2988	36	1	together	together	ADV
admet-2988	36	2	,	,	PUNCT
admet-2988	36	3	these	these	DET
admet-2988	36	4	components	component	NOUN
admet-2988	36	5	provide	provide	VERB
admet-2988	36	6	both	both	PRON
admet-2988	36	7	physical	physical	ADJ
admet-2988	36	8	protection	protection	NOUN
admet-2988	36	9	and	and	CCONJ
admet-2988	36	10	metabolic	metabolic	NOUN
admet-2988	36	11	support	support	NOUN
admet-2988	36	12	to	to	ADP
admet-2988	36	13	the	the	DET
admet-2988	36	14	cns	cns	NOUN
admet-2988	37	1	[	[	X
admet-2988	37	2	10	10	NUM
admet-2988	37	3	]	]	PUNCT
admet-2988	37	4	.	.	PUNCT
admet-2988	38	1	additionally	additionally	ADV
admet-2988	38	2	,	,	PUNCT
admet-2988	38	3	the	the	DET
admet-2988	38	4	nvu	nvu	NOUN
admet-2988	38	5	acts	act	VERB
admet-2988	38	6	as	as	ADP
admet-2988	38	7	a	a	DET
admet-2988	38	8	metabolically	metabolically	ADV
admet-2988	38	9	active	active	ADJ
admet-2988	38	10	interface	interface	NOUN
admet-2988	38	11	,	,	PUNCT
admet-2988	38	12	exposing	expose	VERB
admet-2988	38	13	penetrant	penetrant	NOUN
admet-2988	38	14	substances	substance	NOUN
admet-2988	38	15	to	to	PART
admet-2988	38	16	enzymatic	enzymatic	ADJ
admet-2988	38	17	degradation	degradation	NOUN
admet-2988	38	18	or	or	CCONJ
admet-2988	38	19	active	active	ADJ
admet-2988	38	20	efflux	efflux	NOUN
admet-2988	38	21	mechanisms	mechanism	NOUN
admet-2988	38	22	that	that	PRON
admet-2988	38	23	further	far	ADV
admet-2988	38	24	enhance	enhance	VERB
admet-2988	38	25	its	its	PRON
admet-2988	38	26	protective	protective	ADJ
admet-2988	38	27	role	role	NOUN
admet-2988	38	28	[	[	X
admet-2988	38	29	5,22	5,22	NUM
admet-2988	38	30	-	-	SYM
admet-2988	38	31	24	24	NUM
admet-2988	38	32	]	]	PUNCT
admet-2988	38	33	.	.	PUNCT
admet-2988	39	1	admet	admet	PROPN
admet-2988	39	2	&	&	CCONJ
admet-2988	39	3	dmpk	dmpk	PROPN
admet-2988	39	4	13(5	13(5	NUM
admet-2988	39	5	)	)	PUNCT
admet-2988	39	6	(	(	PUNCT
admet-2988	39	7	2025	2025	NUM
admet-2988	39	8	)	)	PUNCT
admet-2988	39	9	2988	2988	NUM
admet-2988	39	10	advancing	advance	VERB
admet-2988	39	11	through	through	ADP
admet-2988	39	12	the	the	DET
admet-2988	39	13	blood	blood	NOUN
admet-2988	39	14	-	-	PUNCT
admet-2988	39	15	brain	brain	NOUN
admet-2988	39	16	barrier	barrier	NOUN
admet-2988	39	17	doi	doi	NOUN
admet-2988	39	18	:	:	PUNCT
admet-2988	39	19	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	39	20	3	3	NUM
admet-2988	39	21	figure	figure	NOUN
admet-2988	39	22	1	1	NUM
admet-2988	39	23	.	.	PUNCT
admet-2988	39	24	major	major	ADJ
admet-2988	39	25	research	research	NOUN
admet-2988	39	26	milestones	milestone	NOUN
admet-2988	39	27	in	in	ADP
admet-2988	39	28	the	the	DET
admet-2988	39	29	development	development	NOUN
admet-2988	39	30	of	of	ADP
admet-2988	39	31	the	the	DET
admet-2988	39	32	bbb	bbb	PROPN
admet-2988	39	33	concept	concept	NOUN
admet-2988	39	34	.	.	PUNCT
admet-2988	40	1	abbreviations	abbreviation	NOUN
admet-2988	40	2	:	:	PUNCT
admet-2988	41	1	bcrp	bcrp	ADV
admet-2988	41	2	:	:	PUNCT
admet-2988	41	3	breast	breast	NOUN
admet-2988	41	4	cancer	cancer	NOUN
admet-2988	41	5	resistance	resistance	NOUN
admet-2988	41	6	protein	protein	NOUN
admet-2988	41	7	;	;	PUNCT
admet-2988	41	8	ecs	ec	NOUN
admet-2988	41	9	:	:	PUNCT
admet-2988	41	10	endothelial	endothelial	ADJ
admet-2988	41	11	cells	cell	NOUN
admet-2988	41	12	;	;	PUNCT
admet-2988	41	13	ipscs	ipsc	NOUN
admet-2988	41	14	:	:	PUNCT
admet-2988	41	15	induced	induce	VERB
admet-2988	41	16	pluripotent	pluripotent	ADJ
admet-2988	41	17	stem	stem	NOUN
admet-2988	41	18	cells	cell	NOUN
admet-2988	41	19	;	;	PUNCT
admet-2988	41	20	p	p	X
admet-2988	41	21	-	-	PUNCT
admet-2988	41	22	gp	gp	NOUN
admet-2988	41	23	:	:	PUNCT
admet-2988	41	24	p	p	X
admet-2988	41	25	-	-	PUNCT
admet-2988	41	26	glycoprotein	glycoprotein	NOUN
admet-2988	41	27	;	;	PUNCT
admet-2988	41	28	teer	teer	NOUN
admet-2988	41	29	:	:	PUNCT
admet-2988	41	30	transendothelial	transendothelial	PROPN
admet-2988	41	31	electric	electric	ADJ
admet-2988	41	32	resistance	resistance	NOUN
admet-2988	41	33	,	,	PUNCT
admet-2988	41	34	γ	γ	PROPN
admet-2988	41	35	-	-	PUNCT
admet-2988	41	36	gt	gt	PROPN
admet-2988	41	37	:	:	PUNCT
admet-2988	41	38	γ	γ	NOUN
admet-2988	41	39	-	-	PUNCT
admet-2988	41	40	glutamyltranspeptidase	glutamyltranspeptidase	NOUN
admet-2988	41	41	.	.	PUNCT
admet-2988	42	1	image	image	NOUN
admet-2988	42	2	reproduced	reproduce	VERB
admet-2988	42	3	from	from	ADP
admet-2988	42	4	[	[	X
admet-2988	42	5	6	6	NUM
admet-2988	42	6	]	]	PUNCT
admet-2988	42	7	®	®	NOUN
admet-2988	42	8	cc	cc	NOUN
admet-2988	42	9	by	by	ADP
admet-2988	42	10	4.0	4.0	NUM
admet-2988	42	11	figure	figure	NOUN
admet-2988	42	12	2	2	NUM
admet-2988	42	13	.	.	PUNCT
admet-2988	42	14	structure	structure	NOUN
admet-2988	42	15	of	of	ADP
admet-2988	42	16	the	the	DET
admet-2988	42	17	neurovascular	neurovascular	ADJ
admet-2988	42	18	unit	unit	NOUN
admet-2988	42	19	.	.	PUNCT
admet-2988	43	1	tight	tight	ADJ
admet-2988	43	2	junctions	junction	NOUN
admet-2988	43	3	between	between	ADP
admet-2988	43	4	endothelial	endothelial	ADJ
admet-2988	43	5	cells	cell	NOUN
admet-2988	43	6	restrict	restrict	VERB
admet-2988	43	7	paracellular	paracellular	ADJ
admet-2988	43	8	transport	transport	NOUN
admet-2988	43	9	,	,	PUNCT
admet-2988	43	10	while	while	SCONJ
admet-2988	43	11	pericytes	pericyte	NOUN
admet-2988	43	12	partially	partially	ADV
admet-2988	43	13	surround	surround	VERB
admet-2988	43	14	the	the	DET
admet-2988	43	15	endothelium	endothelium	NOUN
admet-2988	43	16	.	.	PUNCT
admet-2988	44	1	the	the	DET
admet-2988	44	2	basal	basal	ADJ
admet-2988	44	3	lamina	lamina	NOUN
admet-2988	44	4	envelops	envelop	VERB
admet-2988	44	5	both	both	DET
admet-2988	44	6	pericytes	pericyte	NOUN
admet-2988	44	7	and	and	CCONJ
admet-2988	44	8	endothelial	endothelial	ADJ
admet-2988	44	9	cells	cell	NOUN
admet-2988	44	10	,	,	PUNCT
admet-2988	44	11	and	and	CCONJ
admet-2988	44	12	is	be	AUX
admet-2988	44	13	further	far	ADV
admet-2988	44	14	surrounded	surround	VERB
admet-2988	44	15	by	by	ADP
admet-2988	44	16	astrocytes	astrocyte	NOUN
admet-2988	44	17	,	,	PUNCT
admet-2988	44	18	which	which	PRON
admet-2988	44	19	help	help	VERB
admet-2988	44	20	maintain	maintain	VERB
admet-2988	44	21	barrier	barrier	NOUN
admet-2988	44	22	properties	property	NOUN
admet-2988	44	23	.	.	PUNCT
admet-2988	45	1	neurons	neuron	NOUN
admet-2988	45	2	release	release	VERB
admet-2988	45	3	vasoactive	vasoactive	ADJ
admet-2988	45	4	neurotransmitters	neurotransmitter	NOUN
admet-2988	45	5	to	to	PART
admet-2988	45	6	regulate	regulate	VERB
admet-2988	45	7	blood	blood	NOUN
admet-2988	45	8	flow	flow	NOUN
admet-2988	45	9	,	,	PUNCT
admet-2988	45	10	and	and	CCONJ
admet-2988	45	11	microglia	microglia	NOUN
admet-2988	45	12	contribute	contribute	VERB
admet-2988	45	13	to	to	ADP
admet-2988	45	14	immune	immune	ADJ
admet-2988	45	15	function	function	NOUN
admet-2988	45	16	.	.	PUNCT
admet-2988	46	1	reproduced	reproduce	VERB
admet-2988	46	2	with	with	ADP
admet-2988	46	3	permission	permission	NOUN
admet-2988	46	4	from	from	ADP
admet-2988	46	5	[	[	X
admet-2988	46	6	25	25	NUM
admet-2988	46	7	]	]	PUNCT
admet-2988	46	8	®	®	NOUN
admet-2988	46	9	endothelial	endothelial	ADJ
admet-2988	46	10	cells	cell	NOUN
admet-2988	46	11	cerebral	cerebral	ADJ
admet-2988	46	12	capillary	capillary	ADJ
admet-2988	46	13	endothelial	endothelial	NOUN
admet-2988	46	14	cells	cell	NOUN
admet-2988	46	15	(	(	PUNCT
admet-2988	46	16	ecs	ec	NOUN
admet-2988	46	17	)	)	PUNCT
admet-2988	46	18	are	be	AUX
admet-2988	46	19	the	the	DET
admet-2988	46	20	principal	principal	ADJ
admet-2988	46	21	structural	structural	ADJ
admet-2988	46	22	component	component	NOUN
admet-2988	46	23	of	of	ADP
admet-2988	46	24	the	the	DET
admet-2988	46	25	bbb	bbb	NOUN
admet-2988	47	1	[	[	X
admet-2988	47	2	23,24	23,24	NUM
admet-2988	47	3	]	]	PUNCT
admet-2988	47	4	.	.	PUNCT
admet-2988	48	1	compared	compare	VERB
admet-2988	48	2	to	to	ADP
admet-2988	48	3	ecs	ecs	PROPN
admet-2988	48	4	in	in	ADP
admet-2988	48	5	other	other	ADJ
admet-2988	48	6	vascular	vascular	ADJ
admet-2988	48	7	systems	system	NOUN
admet-2988	48	8	,	,	PUNCT
admet-2988	48	9	those	those	PRON
admet-2988	48	10	in	in	ADP
admet-2988	48	11	the	the	DET
admet-2988	48	12	brain	brain	NOUN
admet-2988	48	13	exhibit	exhibit	VERB
admet-2988	48	14	distinct	distinct	ADJ
admet-2988	48	15	functional	functional	ADJ
admet-2988	48	16	and	and	CCONJ
admet-2988	48	17	morphological	morphological	ADJ
admet-2988	48	18	features	feature	NOUN
admet-2988	48	19	.	.	PUNCT
admet-2988	49	1	first	first	ADV
admet-2988	49	2	,	,	PUNCT
admet-2988	49	3	they	they	PRON
admet-2988	49	4	have	have	VERB
admet-2988	49	5	a	a	DET
admet-2988	49	6	negatively	negatively	ADV
admet-2988	49	7	charged	charge	VERB
admet-2988	49	8	luminal	luminal	ADJ
admet-2988	49	9	surface	surface	NOUN
admet-2988	49	10	that	that	PRON
admet-2988	49	11	repels	repel	VERB
admet-2988	49	12	polar	polar	ADJ
admet-2988	49	13	molecules	molecule	NOUN
admet-2988	49	14	and	and	CCONJ
admet-2988	49	15	exhibit	exhibit	VERB
admet-2988	49	16	pronounced	pronounce	VERB
admet-2988	49	17	membrane	membrane	NOUN
admet-2988	49	18	polarization	polarization	NOUN
admet-2988	49	19	between	between	ADP
admet-2988	49	20	the	the	DET
admet-2988	49	21	luminal	luminal	NOUN
admet-2988	49	22	(	(	PUNCT
admet-2988	49	23	facing	face	VERB
admet-2988	49	24	the	the	DET
admet-2988	49	25	bloodstream	bloodstream	NOUN
admet-2988	49	26	)	)	PUNCT
admet-2988	49	27	and	and	CCONJ
admet-2988	49	28	the	the	DET
admet-2988	49	29	abluminal	abluminal	NOUN
admet-2988	49	30	(	(	PUNCT
admet-2988	49	31	facing	face	VERB
admet-2988	49	32	the	the	DET
admet-2988	49	33	cns	cns	NOUN
admet-2988	49	34	)	)	PUNCT
admet-2988	49	35	sides	side	NOUN
admet-2988	49	36	,	,	PUNCT
admet-2988	49	37	thereby	thereby	ADV
admet-2988	49	38	limiting	limit	VERB
admet-2988	49	39	non	non	ADJ
admet-2988	49	40	-	-	ADJ
admet-2988	49	41	specific	specific	ADJ
admet-2988	49	42	interactions	interaction	NOUN
admet-2988	49	43	with	with	ADP
admet-2988	49	44	circulating	circulate	VERB
admet-2988	49	45	substances	substance	NOUN
admet-2988	49	46	.	.	PUNCT
admet-2988	50	1	second	second	ADJ
admet-2988	50	2	,	,	PUNCT
admet-2988	50	3	cerebral	cerebral	ADJ
admet-2988	50	4	ecs	ecs	PROPN
admet-2988	50	5	lack	lack	NOUN
admet-2988	50	6	fenestrations	fenestration	NOUN
admet-2988	51	1	[	[	X
admet-2988	51	2	26,27	26,27	NUM
admet-2988	51	3	]	]	PUNCT
admet-2988	51	4	,	,	PUNCT
admet-2988	51	5	reducing	reduce	VERB
admet-2988	51	6	the	the	DET
admet-2988	51	7	surface	surface	NOUN
admet-2988	51	8	area	area	NOUN
admet-2988	51	9	available	available	ADJ
admet-2988	51	10	for	for	ADP
admet-2988	51	11	molecular	molecular	ADJ
admet-2988	51	12	exchange	exchange	NOUN
admet-2988	51	13	.	.	PUNCT
admet-2988	52	1	they	they	PRON
admet-2988	52	2	are	be	AUX
admet-2988	52	3	tightly	tightly	ADV
admet-2988	52	4	sealed	seal	VERB
admet-2988	52	5	by	by	ADP
admet-2988	52	6	intercellular	intercellular	ADJ
admet-2988	52	7	junction	junction	NOUN
admet-2988	52	8	complexes	complex	NOUN
admet-2988	52	9	,	,	PUNCT
admet-2988	52	10	comprising	comprise	VERB
admet-2988	52	11	tight	tight	ADJ
admet-2988	52	12	junctions	junction	NOUN
admet-2988	52	13	and	and	CCONJ
admet-2988	52	14	adhesion	adhesion	NOUN
admet-2988	52	15	proteins	protein	NOUN
admet-2988	52	16	,	,	PUNCT
admet-2988	52	17	which	which	PRON
admet-2988	52	18	restrict	restrict	VERB
admet-2988	52	19	the	the	DET
admet-2988	52	20	paracellular	paracellular	ADJ
admet-2988	52	21	passage	passage	NOUN
admet-2988	52	22	of	of	ADP
admet-2988	52	23	substances	substance	NOUN
admet-2988	52	24	.	.	PUNCT
admet-2988	53	1	in	in	ADP
admet-2988	53	2	addition	addition	NOUN
admet-2988	53	3	,	,	PUNCT
admet-2988	53	4	these	these	DET
admet-2988	53	5	cells	cell	NOUN
admet-2988	53	6	display	display	VERB
admet-2988	53	7	a	a	DET
admet-2988	53	8	higher	high	ADJ
admet-2988	53	9	metabolic	metabolic	NOUN
admet-2988	53	10	rate	rate	NOUN
admet-2988	53	11	compared	compare	VERB
admet-2988	53	12	to	to	ADP
admet-2988	53	13	ecs	ecs	PROPN
admet-2988	53	14	,	,	PUNCT
admet-2988	53	15	supporting	support	VERB
admet-2988	53	16	active	active	ADJ
admet-2988	53	17	,	,	PUNCT
admet-2988	53	18	protein	protein	NOUN
admet-2988	53	19	-	-	PUNCT
admet-2988	53	20	mediated	mediate	VERB
admet-2988	53	21	transport	transport	NOUN
admet-2988	53	22	systems	system	NOUN
admet-2988	53	23	that	that	PRON
admet-2988	53	24	regulate	regulate	VERB
admet-2988	53	25	selective	selective	ADJ
admet-2988	53	26	nutrient	nutrient	NOUN
admet-2988	53	27	uptake	uptake	ADJ
admet-2988	53	28	and	and	CCONJ
admet-2988	53	29	xenobiotic	xenobiotic	ADJ
admet-2988	53	30	clearance	clearance	NOUN
admet-2988	53	31	,	,	PUNCT
admet-2988	53	32	while	while	SCONJ
admet-2988	53	33	exhibiting	exhibit	VERB
admet-2988	53	34	reduced	reduce	VERB
admet-2988	53	35	pinocytic	pinocytic	ADJ
admet-2988	53	36	activity	activity	NOUN
admet-2988	53	37	[	[	X
admet-2988	53	38	5,26	5,26	NUM
admet-2988	53	39	-	-	SYM
admet-2988	53	40	29	29	NUM
admet-2988	53	41	]	]	PUNCT
admet-2988	53	42	.	.	PUNCT
admet-2988	54	1	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	54	2	r.	r.	PROPN
admet-2988	54	3	vargas	vargas	PROPN
admet-2988	54	4	et	et	PROPN
admet-2988	54	5	al	al	PROPN
admet-2988	54	6	.	.	PROPN
admet-2988	54	7	admet	admet	PROPN
admet-2988	54	8	&	&	CCONJ
admet-2988	54	9	dmpk	dmpk	PROPN
admet-2988	54	10	13(5	13(5	NUM
admet-2988	54	11	)	)	PUNCT
admet-2988	54	12	(	(	PUNCT
admet-2988	54	13	2025	2025	NUM
admet-2988	54	14	)	)	PUNCT
admet-2988	54	15	2988	2988	NUM
admet-2988	54	16	4	4	NUM
admet-2988	54	17	tight	tight	ADJ
admet-2988	54	18	junctions	junction	NOUN
admet-2988	54	19	tight	tight	ADJ
admet-2988	54	20	junctions	junction	NOUN
admet-2988	54	21	(	(	PUNCT
admet-2988	54	22	tjs	tjs	NOUN
admet-2988	54	23	)	)	PUNCT
admet-2988	54	24	between	between	ADP
admet-2988	54	25	endothelial	endothelial	ADJ
admet-2988	54	26	cells	cell	NOUN
admet-2988	54	27	are	be	AUX
admet-2988	54	28	a	a	DET
admet-2988	54	29	key	key	ADJ
admet-2988	54	30	feature	feature	NOUN
admet-2988	54	31	of	of	ADP
admet-2988	54	32	the	the	DET
admet-2988	54	33	restrictive	restrictive	ADJ
admet-2988	54	34	permeability	permeability	NOUN
admet-2988	54	35	of	of	ADP
admet-2988	54	36	the	the	DET
admet-2988	54	37	bbb	bbb	NOUN
admet-2988	55	1	[	[	X
admet-2988	55	2	24	24	NUM
admet-2988	55	3	]	]	PUNCT
admet-2988	55	4	.	.	PUNCT
admet-2988	56	1	these	these	DET
admet-2988	56	2	junctions	junction	NOUN
admet-2988	56	3	consist	consist	VERB
admet-2988	56	4	of	of	ADP
admet-2988	56	5	a	a	DET
admet-2988	56	6	complex	complex	ADJ
admet-2988	56	7	network	network	NOUN
admet-2988	56	8	of	of	ADP
admet-2988	56	9	proteins	protein	NOUN
admet-2988	56	10	that	that	PRON
admet-2988	56	11	seal	seal	VERB
admet-2988	56	12	the	the	DET
admet-2988	56	13	intercellular	intercellular	ADJ
admet-2988	56	14	spaces	space	NOUN
admet-2988	56	15	,	,	PUNCT
admet-2988	56	16	including	include	VERB
admet-2988	56	17	transmembrane	transmembrane	ADJ
admet-2988	56	18	proteins	protein	NOUN
admet-2988	56	19	(	(	PUNCT
admet-2988	56	20	e.g.	e.g.	ADV
admet-2988	56	21	claudins	claudin	NOUN
admet-2988	56	22	and	and	CCONJ
admet-2988	56	23	occludins	occludin	NOUN
admet-2988	56	24	)	)	PUNCT
admet-2988	56	25	,	,	PUNCT
admet-2988	56	26	cytoplasmic	cytoplasmic	ADJ
admet-2988	56	27	anchoring	anchoring	NOUN
admet-2988	56	28	proteins	protein	NOUN
admet-2988	56	29	(	(	PUNCT
admet-2988	56	30	such	such	ADJ
admet-2988	56	31	as	as	ADP
admet-2988	56	32	cingulin	cingulin	NOUN
admet-2988	56	33	and	and	CCONJ
admet-2988	56	34	zonula	zonula	NOUN
admet-2988	56	35	occludens	occluden	NOUN
admet-2988	56	36	)	)	PUNCT
admet-2988	56	37	,	,	PUNCT
admet-2988	56	38	and	and	CCONJ
admet-2988	56	39	cytoskeletal	cytoskeletal	ADJ
admet-2988	56	40	elements	element	NOUN
admet-2988	56	41	[	[	X
admet-2988	56	42	30	30	NUM
admet-2988	56	43	]	]	PUNCT
admet-2988	56	44	.	.	PUNCT
admet-2988	57	1	together	together	ADV
admet-2988	57	2	,	,	PUNCT
admet-2988	57	3	these	these	DET
admet-2988	57	4	components	component	NOUN
admet-2988	57	5	form	form	VERB
admet-2988	57	6	extensive	extensive	ADJ
admet-2988	57	7	overlapping	overlapping	NOUN
admet-2988	57	8	sealing	seal	VERB
admet-2988	57	9	strands	strand	NOUN
admet-2988	57	10	that	that	PRON
admet-2988	57	11	prevent	prevent	VERB
admet-2988	57	12	the	the	DET
admet-2988	57	13	paracellular	paracellular	ADJ
admet-2988	57	14	passage	passage	NOUN
admet-2988	57	15	of	of	ADP
admet-2988	57	16	polar	polar	ADJ
admet-2988	57	17	molecules	molecule	NOUN
admet-2988	57	18	and	and	CCONJ
admet-2988	57	19	macromolecules	macromolecule	NOUN
admet-2988	57	20	into	into	ADP
admet-2988	57	21	the	the	DET
admet-2988	57	22	cns	cns	NOUN
admet-2988	58	1	[	[	X
admet-2988	58	2	31,32	31,32	NUM
admet-2988	58	3	]	]	PUNCT
admet-2988	58	4	.	.	PUNCT
admet-2988	59	1	beyond	beyond	ADP
admet-2988	59	2	acting	act	VERB
admet-2988	59	3	as	as	ADP
admet-2988	59	4	physical	physical	ADJ
admet-2988	59	5	barriers	barrier	NOUN
admet-2988	59	6	,	,	PUNCT
admet-2988	59	7	tjs	tjs	NOUN
admet-2988	59	8	also	also	ADV
admet-2988	59	9	function	function	VERB
admet-2988	59	10	as	as	ADP
admet-2988	59	11	lateral	lateral	ADJ
admet-2988	59	12	diffusion	diffusion	NOUN
admet-2988	59	13	barriers	barrier	NOUN
admet-2988	59	14	within	within	ADP
admet-2988	59	15	the	the	DET
admet-2988	59	16	endothelial	endothelial	ADJ
admet-2988	59	17	membranes	membrane	NOUN
admet-2988	59	18	,	,	PUNCT
admet-2988	59	19	restricting	restrict	VERB
admet-2988	59	20	the	the	DET
admet-2988	59	21	redistribution	redistribution	NOUN
admet-2988	59	22	of	of	ADP
admet-2988	59	23	transporters	transporter	NOUN
admet-2988	59	24	from	from	ADP
admet-2988	59	25	the	the	DET
admet-2988	59	26	abluminal	abluminal	NOUN
admet-2988	59	27	to	to	ADP
admet-2988	59	28	the	the	DET
admet-2988	59	29	luminal	luminal	ADJ
admet-2988	59	30	side	side	NOUN
admet-2988	59	31	.	.	PUNCT
admet-2988	60	1	this	this	DET
admet-2988	60	2	restriction	restriction	NOUN
admet-2988	60	3	preserves	preserve	VERB
admet-2988	60	4	endothelial	endothelial	ADJ
admet-2988	60	5	polarity	polarity	NOUN
admet-2988	60	6	,	,	PUNCT
admet-2988	60	7	thereby	thereby	ADV
admet-2988	60	8	maintaining	maintain	VERB
admet-2988	60	9	the	the	DET
admet-2988	60	10	functional	functional	ADJ
admet-2988	60	11	integrity	integrity	NOUN
admet-2988	60	12	of	of	ADP
admet-2988	60	13	the	the	DET
admet-2988	60	14	bbb	bbb	PROPN
admet-2988	61	1	[	[	X
admet-2988	61	2	33	33	NUM
admet-2988	61	3	]	]	PUNCT
admet-2988	61	4	.	.	PUNCT
admet-2988	62	1	pericytes	pericyte	NOUN
admet-2988	62	2	pericytes	pericyte	NOUN
admet-2988	62	3	play	play	VERB
admet-2988	62	4	a	a	DET
admet-2988	62	5	fundamental	fundamental	ADJ
admet-2988	62	6	role	role	NOUN
admet-2988	62	7	in	in	ADP
admet-2988	62	8	the	the	DET
admet-2988	62	9	formation	formation	NOUN
admet-2988	62	10	of	of	ADP
admet-2988	62	11	tjs	tjs	NOUN
admet-2988	62	12	,	,	PUNCT
admet-2988	62	13	angiogenesis	angiogenesis	NOUN
admet-2988	62	14	,	,	PUNCT
admet-2988	62	15	and	and	CCONJ
admet-2988	62	16	vascular	vascular	ADJ
admet-2988	62	17	remodelling	remodelling	NOUN
admet-2988	62	18	within	within	ADP
admet-2988	62	19	the	the	DET
admet-2988	62	20	nvu	nvu	NOUN
admet-2988	62	21	[	[	X
admet-2988	62	22	14,23,32	14,23,32	NUM
admet-2988	62	23	]	]	PUNCT
admet-2988	62	24	.	.	PUNCT
admet-2988	63	1	they	they	PRON
admet-2988	63	2	communicate	communicate	VERB
admet-2988	63	3	with	with	ADP
admet-2988	63	4	ecs	ecs	PROPN
admet-2988	63	5	through	through	ADP
admet-2988	63	6	cadherin	cadherin	NOUN
admet-2988	63	7	protein	protein	NOUN
admet-2988	63	8	-	-	PUNCT
admet-2988	63	9	mediated	mediate	VERB
admet-2988	63	10	interactions	interaction	NOUN
admet-2988	63	11	[	[	X
admet-2988	63	12	15,34	15,34	NUM
admet-2988	63	13	]	]	PUNCT
admet-2988	63	14	and	and	CCONJ
admet-2988	63	15	contribute	contribute	VERB
admet-2988	63	16	to	to	ADP
admet-2988	63	17	the	the	DET
admet-2988	63	18	expression	expression	NOUN
admet-2988	63	19	and	and	CCONJ
admet-2988	63	20	polarisation	polarisation	NOUN
admet-2988	63	21	of	of	ADP
admet-2988	63	22	specific	specific	ADJ
admet-2988	63	23	transporters	transporter	NOUN
admet-2988	63	24	on	on	ADP
admet-2988	63	25	ec	ec	PROPN
admet-2988	63	26	membranes	membrane	NOUN
admet-2988	63	27	[	[	X
admet-2988	63	28	15	15	NUM
admet-2988	63	29	]	]	PUNCT
admet-2988	63	30	.	.	PUNCT
admet-2988	64	1	a	a	DET
admet-2988	64	2	reduction	reduction	NOUN
admet-2988	64	3	in	in	ADP
admet-2988	64	4	pericyte	pericyte	NOUN
admet-2988	64	5	density	density	NOUN
admet-2988	64	6	has	have	AUX
admet-2988	64	7	been	be	AUX
admet-2988	64	8	associated	associate	VERB
admet-2988	64	9	with	with	ADP
admet-2988	64	10	impaired	impaired	ADJ
admet-2988	64	11	barrier	barrier	NOUN
admet-2988	64	12	function	function	NOUN
admet-2988	64	13	[	[	X
admet-2988	64	14	35	35	NUM
admet-2988	64	15	]	]	PUNCT
admet-2988	64	16	.	.	PUNCT
admet-2988	65	1	emerging	emerge	VERB
admet-2988	65	2	evidence	evidence	NOUN
admet-2988	65	3	also	also	ADV
admet-2988	65	4	implicates	implicate	VERB
admet-2988	65	5	pericyte	pericyte	NOUN
admet-2988	65	6	loss	loss	NOUN
admet-2988	65	7	in	in	ADP
admet-2988	65	8	the	the	DET
admet-2988	65	9	pathophysiology	pathophysiology	NOUN
admet-2988	65	10	of	of	ADP
admet-2988	65	11	various	various	ADJ
admet-2988	65	12	neurodegenerative	neurodegenerative	ADJ
admet-2988	65	13	diseases	disease	NOUN
admet-2988	65	14	and	and	CCONJ
admet-2988	65	15	neuroinflammatory	neuroinflammatory	NOUN
admet-2988	65	16	processes	process	NOUN
admet-2988	65	17	[	[	X
admet-2988	65	18	36	36	NUM
admet-2988	65	19	]	]	PUNCT
admet-2988	65	20	.	.	PUNCT
admet-2988	66	1	their	their	PRON
admet-2988	66	2	distribution	distribution	NOUN
admet-2988	66	3	along	along	ADP
admet-2988	66	4	cerebral	cerebral	ADJ
admet-2988	66	5	capillaries	capillary	NOUN
admet-2988	66	6	is	be	AUX
admet-2988	66	7	heterogeneous	heterogeneous	ADJ
admet-2988	66	8	,	,	PUNCT
admet-2988	66	9	varying	vary	VERB
admet-2988	66	10	according	accord	VERB
admet-2988	66	11	to	to	ADP
admet-2988	66	12	endothelial	endothelial	ADJ
admet-2988	66	13	thickness	thickness	NOUN
admet-2988	66	14	and	and	CCONJ
admet-2988	66	15	capillary	capillary	ADJ
admet-2988	66	16	diameter	diameter	NOUN
admet-2988	67	1	[	[	X
admet-2988	67	2	34	34	NUM
admet-2988	67	3	]	]	PUNCT
admet-2988	67	4	.	.	PUNCT
admet-2988	68	1	alongside	alongside	ADP
admet-2988	68	2	astrocytes	astrocyte	NOUN
admet-2988	68	3	,	,	PUNCT
admet-2988	68	4	pericytes	pericyte	NOUN
admet-2988	68	5	regulate	regulate	VERB
admet-2988	68	6	vascular	vascular	ADJ
admet-2988	68	7	tone	tone	NOUN
admet-2988	68	8	and	and	CCONJ
admet-2988	68	9	function	function	NOUN
admet-2988	68	10	,	,	PUNCT
admet-2988	68	11	modulate	modulate	VERB
admet-2988	68	12	immune	immune	ADJ
admet-2988	68	13	responses	response	NOUN
admet-2988	68	14	,	,	PUNCT
admet-2988	68	15	and	and	CCONJ
admet-2988	68	16	contribute	contribute	VERB
admet-2988	68	17	to	to	ADP
admet-2988	68	18	metabolic	metabolic	NOUN
admet-2988	68	19	waste	waste	NOUN
admet-2988	68	20	clearance	clearance	NOUN
admet-2988	68	21	[	[	X
admet-2988	68	22	5	5	NUM
admet-2988	68	23	]	]	PUNCT
admet-2988	68	24	.	.	PUNCT
admet-2988	69	1	astrocytes	astrocyte	NOUN
admet-2988	69	2	astrocytes	astrocyte	NOUN
admet-2988	69	3	are	be	AUX
admet-2988	69	4	a	a	DET
admet-2988	69	5	type	type	NOUN
admet-2988	69	6	of	of	ADP
admet-2988	69	7	glial	glial	ADJ
admet-2988	69	8	cell	cell	NOUN
admet-2988	69	9	essential	essential	ADJ
admet-2988	69	10	for	for	ADP
admet-2988	69	11	maintaining	maintain	VERB
admet-2988	69	12	the	the	DET
admet-2988	69	13	neuronal	neuronal	ADJ
admet-2988	69	14	environment	environment	NOUN
admet-2988	69	15	and	and	CCONJ
admet-2988	69	16	regulating	regulate	VERB
admet-2988	69	17	cerebral	cerebral	ADJ
admet-2988	69	18	signalling	signal	VERB
admet-2988	69	19	dynamics	dynamic	NOUN
admet-2988	69	20	[	[	X
admet-2988	69	21	3,9,37	3,9,37	NUM
admet-2988	69	22	]	]	X
admet-2988	69	23	.	.	PUNCT
admet-2988	70	1	they	they	PRON
admet-2988	70	2	contribute	contribute	VERB
admet-2988	70	3	to	to	ADP
admet-2988	70	4	neurotransmitter	neurotransmitter	NOUN
admet-2988	70	5	homeostasis	homeostasis	NOUN
admet-2988	70	6	,	,	PUNCT
admet-2988	70	7	waste	waste	NOUN
admet-2988	70	8	clearance	clearance	NOUN
admet-2988	70	9	,	,	PUNCT
admet-2988	70	10	cerebral	cerebral	ADJ
admet-2988	70	11	blood	blood	NOUN
admet-2988	70	12	flow	flow	NOUN
admet-2988	70	13	regulation	regulation	NOUN
admet-2988	70	14	,	,	PUNCT
admet-2988	70	15	ion	ion	NOUN
admet-2988	70	16	metabolism	metabolism	NOUN
admet-2988	70	17	,	,	PUNCT
admet-2988	70	18	and	and	CCONJ
admet-2988	70	19	neuroimmune	neuroimmune	NOUN
admet-2988	70	20	coordination	coordination	NOUN
admet-2988	70	21	[	[	X
admet-2988	70	22	5,9	5,9	NUM
admet-2988	70	23	]	]	X
admet-2988	70	24	.	.	PUNCT
admet-2988	71	1	strategically	strategically	ADV
admet-2988	71	2	located	locate	VERB
admet-2988	71	3	between	between	ADP
admet-2988	71	4	neuronal	neuronal	ADJ
admet-2988	71	5	synapses	synapsis	NOUN
admet-2988	71	6	and	and	CCONJ
admet-2988	71	7	the	the	DET
admet-2988	71	8	cerebral	cerebral	ADJ
admet-2988	71	9	vasculature	vasculature	NOUN
admet-2988	71	10	(	(	PUNCT
admet-2988	71	11	figure	figure	NOUN
admet-2988	71	12	2	2	NUM
admet-2988	71	13	)	)	PUNCT
admet-2988	71	14	,	,	PUNCT
admet-2988	71	15	astrocytes	astrocyte	NOUN
admet-2988	71	16	play	play	VERB
admet-2988	71	17	a	a	DET
admet-2988	71	18	central	central	ADJ
admet-2988	71	19	role	role	NOUN
admet-2988	71	20	in	in	ADP
admet-2988	71	21	the	the	DET
admet-2988	71	22	formation	formation	NOUN
admet-2988	71	23	and	and	CCONJ
admet-2988	71	24	maintenance	maintenance	NOUN
admet-2988	71	25	of	of	ADP
admet-2988	71	26	the	the	DET
admet-2988	71	27	bbb	bbb	NOUN
admet-2988	72	1	[	[	X
admet-2988	72	2	9,18	9,18	X
admet-2988	72	3	]	]	PUNCT
admet-2988	72	4	.	.	PUNCT
admet-2988	73	1	they	they	PRON
admet-2988	73	2	secrete	secrete	VERB
admet-2988	73	3	various	various	ADJ
admet-2988	73	4	factors	factor	NOUN
admet-2988	73	5	that	that	PRON
admet-2988	73	6	modulate	modulate	VERB
admet-2988	73	7	the	the	DET
admet-2988	73	8	expression	expression	NOUN
admet-2988	73	9	of	of	ADP
admet-2988	73	10	adhesion	adhesion	NOUN
admet-2988	73	11	proteins	protein	NOUN
admet-2988	73	12	and	and	CCONJ
admet-2988	73	13	endothelial	endothelial	ADJ
admet-2988	73	14	growth	growth	NOUN
admet-2988	73	15	factors	factor	NOUN
admet-2988	73	16	[	[	X
admet-2988	73	17	38	38	NUM
admet-2988	73	18	]	]	PUNCT
admet-2988	73	19	,	,	PUNCT
admet-2988	73	20	which	which	PRON
admet-2988	73	21	are	be	AUX
admet-2988	73	22	essential	essential	ADJ
admet-2988	73	23	for	for	ADP
admet-2988	73	24	establishing	establish	VERB
admet-2988	73	25	and	and	CCONJ
admet-2988	73	26	preserving	preserve	VERB
admet-2988	73	27	the	the	DET
admet-2988	73	28	selective	selective	ADJ
admet-2988	73	29	permeability	permeability	NOUN
admet-2988	73	30	of	of	ADP
admet-2988	73	31	the	the	DET
admet-2988	73	32	bbb	bbb	NOUN
admet-2988	74	1	[	[	X
admet-2988	74	2	39,40	39,40	NUM
admet-2988	74	3	]	]	PUNCT
admet-2988	74	4	.	.	PUNCT
admet-2988	75	1	astrocyte	astrocyte	NOUN
admet-2988	75	2	degeneration	degeneration	NOUN
admet-2988	75	3	or	or	CCONJ
admet-2988	75	4	dysfunction	dysfunction	NOUN
admet-2988	75	5	is	be	AUX
admet-2988	75	6	recognized	recognize	VERB
admet-2988	75	7	as	as	ADP
admet-2988	75	8	a	a	DET
admet-2988	75	9	critical	critical	ADJ
admet-2988	75	10	factor	factor	NOUN
admet-2988	75	11	in	in	ADP
admet-2988	75	12	the	the	DET
admet-2988	75	13	progression	progression	NOUN
admet-2988	75	14	of	of	ADP
admet-2988	75	15	several	several	ADJ
admet-2988	75	16	neurodegenerative	neurodegenerative	ADJ
admet-2988	75	17	diseases	disease	NOUN
admet-2988	75	18	[	[	X
admet-2988	75	19	37	37	NUM
admet-2988	75	20	]	]	PUNCT
admet-2988	75	21	.	.	PUNCT
admet-2988	76	1	microglia	microglia	ADJ
admet-2988	76	2	microglia	microglia	NOUN
admet-2988	76	3	,	,	PUNCT
admet-2988	76	4	another	another	DET
admet-2988	76	5	subtype	subtype	NOUN
admet-2988	76	6	of	of	ADP
admet-2988	76	7	glial	glial	ADJ
admet-2988	76	8	cells	cell	NOUN
admet-2988	76	9	,	,	PUNCT
admet-2988	76	10	are	be	AUX
admet-2988	76	11	central	central	ADJ
admet-2988	76	12	regulators	regulator	NOUN
admet-2988	76	13	of	of	ADP
admet-2988	76	14	neuroinflammation	neuroinflammation	NOUN
admet-2988	76	15	and	and	CCONJ
admet-2988	76	16	immune	immune	ADJ
admet-2988	76	17	surveillance	surveillance	NOUN
admet-2988	76	18	within	within	ADP
admet-2988	76	19	the	the	DET
admet-2988	76	20	cns	cns	NOUN
admet-2988	76	21	.	.	PUNCT
admet-2988	77	1	they	they	PRON
admet-2988	77	2	contribute	contribute	VERB
admet-2988	77	3	to	to	ADP
admet-2988	77	4	brain	brain	NOUN
admet-2988	77	5	homeostasis	homeostasis	NOUN
admet-2988	77	6	by	by	ADP
admet-2988	77	7	clearing	clear	VERB
admet-2988	77	8	foreign	foreign	ADJ
admet-2988	77	9	particles	particle	NOUN
admet-2988	77	10	,	,	PUNCT
admet-2988	77	11	participating	participate	VERB
admet-2988	77	12	in	in	ADP
admet-2988	77	13	tissue	tissue	NOUN
admet-2988	77	14	repair	repair	NOUN
admet-2988	77	15	,	,	PUNCT
admet-2988	77	16	and	and	CCONJ
admet-2988	77	17	mediating	mediate	VERB
admet-2988	77	18	extracellular	extracellular	ADJ
admet-2988	77	19	signalling	signal	VERB
admet-2988	77	20	pathways	pathway	NOUN
admet-2988	78	1	[	[	X
admet-2988	78	2	41	41	NUM
admet-2988	78	3	]	]	PUNCT
admet-2988	78	4	.	.	PUNCT
admet-2988	79	1	their	their	PRON
admet-2988	79	2	distribution	distribution	NOUN
admet-2988	79	3	within	within	ADP
admet-2988	79	4	the	the	DET
admet-2988	79	5	brain	brain	NOUN
admet-2988	79	6	parenchyma	parenchyma	NOUN
admet-2988	79	7	is	be	AUX
admet-2988	79	8	highly	highly	ADV
admet-2988	79	9	context	context	NOUN
admet-2988	79	10	dependent	dependent	ADJ
admet-2988	79	11	;	;	PUNCT
admet-2988	79	12	for	for	ADP
admet-2988	79	13	example	example	NOUN
admet-2988	79	14	,	,	PUNCT
admet-2988	79	15	microglial	microglial	ADJ
admet-2988	79	16	density	density	NOUN
admet-2988	79	17	increases	increase	NOUN
admet-2988	79	18	in	in	ADP
admet-2988	79	19	areas	area	NOUN
admet-2988	79	20	adjacent	adjacent	ADJ
admet-2988	79	21	to	to	ADP
admet-2988	79	22	capillaries	capillary	NOUN
admet-2988	79	23	in	in	ADP
admet-2988	79	24	response	response	NOUN
admet-2988	79	25	to	to	ADP
admet-2988	79	26	inflammation	inflammation	NOUN
admet-2988	79	27	or	or	CCONJ
admet-2988	79	28	neuronal	neuronal	ADJ
admet-2988	79	29	damage	damage	NOUN
admet-2988	79	30	[	[	X
admet-2988	79	31	42	42	NUM
admet-2988	79	32	]	]	PUNCT
admet-2988	79	33	.	.	PUNCT
admet-2988	80	1	emerging	emerge	VERB
admet-2988	80	2	evidence	evidence	NOUN
admet-2988	80	3	suggests	suggest	VERB
admet-2988	80	4	that	that	SCONJ
admet-2988	80	5	microglial	microglial	ADJ
admet-2988	80	6	activity	activity	NOUN
admet-2988	80	7	can	can	AUX
admet-2988	80	8	modulate	modulate	VERB
admet-2988	80	9	the	the	DET
admet-2988	80	10	expression	expression	NOUN
admet-2988	80	11	of	of	ADP
admet-2988	80	12	tjs	tjs	NOUN
admet-2988	80	13	proteins	protein	NOUN
admet-2988	80	14	,	,	PUNCT
admet-2988	80	15	thereby	thereby	ADV
admet-2988	80	16	influencing	influence	VERB
admet-2988	80	17	bbb	bbb	NOUN
admet-2988	80	18	integrity	integrity	NOUN
admet-2988	80	19	[	[	X
admet-2988	80	20	43	43	NUM
admet-2988	80	21	]	]	PUNCT
admet-2988	80	22	.	.	PUNCT
admet-2988	81	1	given	give	VERB
admet-2988	81	2	the	the	DET
admet-2988	81	3	heterogeneity	heterogeneity	NOUN
admet-2988	81	4	of	of	ADP
admet-2988	81	5	microglial	microglial	ADJ
admet-2988	81	6	subtypes	subtype	NOUN
admet-2988	81	7	and	and	CCONJ
admet-2988	81	8	their	their	PRON
admet-2988	81	9	multifaceted	multifaceted	ADJ
admet-2988	81	10	roles	role	NOUN
admet-2988	81	11	beyond	beyond	ADP
admet-2988	81	12	bbb	bbb	PROPN
admet-2988	81	13	regulation	regulation	NOUN
admet-2988	81	14	,	,	PUNCT
admet-2988	81	15	further	further	ADJ
admet-2988	81	16	investigation	investigation	NOUN
admet-2988	81	17	is	be	AUX
admet-2988	81	18	warranted	warrant	VERB
admet-2988	81	19	to	to	PART
admet-2988	81	20	elucidate	elucidate	VERB
admet-2988	81	21	their	their	PRON
admet-2988	81	22	broader	broad	ADJ
admet-2988	81	23	impact	impact	NOUN
admet-2988	81	24	on	on	ADP
admet-2988	81	25	cns	cns	PROPN
admet-2988	81	26	physiology	physiology	NOUN
admet-2988	81	27	and	and	CCONJ
admet-2988	81	28	pathology	pathology	NOUN
admet-2988	81	29	[	[	X
admet-2988	81	30	27	27	NUM
admet-2988	81	31	]	]	PUNCT
admet-2988	81	32	.	.	PUNCT
admet-2988	82	1	basal	basal	PROPN
admet-2988	82	2	lamina	lamina	NOUN
admet-2988	82	3	the	the	DET
admet-2988	82	4	basal	basal	ADJ
admet-2988	82	5	lamina	lamina	NOUN
admet-2988	82	6	(	(	PUNCT
admet-2988	82	7	bl	bl	INTJ
admet-2988	82	8	)	)	PUNCT
admet-2988	82	9	is	be	AUX
admet-2988	82	10	the	the	DET
admet-2988	82	11	acellular	acellular	ADJ
admet-2988	82	12	component	component	NOUN
admet-2988	82	13	of	of	ADP
admet-2988	82	14	the	the	DET
admet-2988	82	15	bbb	bbb	NOUN
admet-2988	82	16	,	,	PUNCT
admet-2988	82	17	comprising	comprise	VERB
admet-2988	82	18	a	a	DET
admet-2988	82	19	specialized	specialized	ADJ
admet-2988	82	20	network	network	NOUN
admet-2988	82	21	of	of	ADP
admet-2988	82	22	extracellular	extracellular	ADJ
admet-2988	82	23	matrix	matrix	NOUN
admet-2988	82	24	proteins	protein	NOUN
admet-2988	82	25	that	that	PRON
admet-2988	82	26	provides	provide	VERB
admet-2988	82	27	structural	structural	ADJ
admet-2988	82	28	support	support	NOUN
admet-2988	82	29	and	and	CCONJ
admet-2988	82	30	anchorage	anchorage	NOUN
admet-2988	82	31	for	for	ADP
admet-2988	82	32	the	the	DET
admet-2988	82	33	surrounding	surround	VERB
admet-2988	82	34	cellular	cellular	ADJ
admet-2988	82	35	elements	element	NOUN
admet-2988	82	36	[	[	X
admet-2988	82	37	23,27	23,27	NUM
admet-2988	82	38	]	]	PUNCT
admet-2988	82	39	.	.	PUNCT
admet-2988	83	1	admet	admet	PROPN
admet-2988	83	2	&	&	CCONJ
admet-2988	83	3	dmpk	dmpk	PROPN
admet-2988	83	4	13(5	13(5	NUM
admet-2988	83	5	)	)	PUNCT
admet-2988	83	6	(	(	PUNCT
admet-2988	83	7	2025	2025	NUM
admet-2988	83	8	)	)	PUNCT
admet-2988	83	9	2988	2988	NUM
admet-2988	83	10	advancing	advance	VERB
admet-2988	83	11	through	through	ADP
admet-2988	83	12	the	the	DET
admet-2988	83	13	blood	blood	NOUN
admet-2988	83	14	-	-	PUNCT
admet-2988	83	15	brain	brain	NOUN
admet-2988	83	16	barrier	barrier	NOUN
admet-2988	83	17	doi	doi	NOUN
admet-2988	83	18	:	:	PUNCT
admet-2988	83	19	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	83	20	5	5	NUM
admet-2988	83	21	beyond	beyond	ADP
admet-2988	83	22	mechanical	mechanical	ADJ
admet-2988	83	23	stability	stability	NOUN
admet-2988	83	24	,	,	PUNCT
admet-2988	83	25	the	the	DET
admet-2988	83	26	bl	bl	PROPN
admet-2988	83	27	is	be	AUX
admet-2988	83	28	essential	essential	ADJ
admet-2988	83	29	for	for	ADP
admet-2988	83	30	ecs	ecs	NOUN
admet-2988	83	31	polarization	polarization	NOUN
admet-2988	83	32	and	and	CCONJ
admet-2988	83	33	the	the	DET
admet-2988	83	34	regulation	regulation	NOUN
admet-2988	83	35	of	of	ADP
admet-2988	83	36	intercellular	intercellular	ADJ
admet-2988	83	37	signalling	signal	VERB
admet-2988	83	38	[	[	X
admet-2988	83	39	43	43	NUM
admet-2988	83	40	]	]	PUNCT
admet-2988	83	41	.	.	PUNCT
admet-2988	84	1	this	this	DET
admet-2988	84	2	network	network	NOUN
admet-2988	84	3	is	be	AUX
admet-2988	84	4	mainly	mainly	ADV
admet-2988	84	5	composed	compose	VERB
admet-2988	84	6	of	of	ADP
admet-2988	84	7	collagen	collagen	NOUN
admet-2988	84	8	,	,	PUNCT
admet-2988	84	9	laminin	laminin	NOUN
admet-2988	84	10	,	,	PUNCT
admet-2988	84	11	fibronectin	fibronectin	NOUN
admet-2988	84	12	,	,	PUNCT
admet-2988	84	13	entactin	entactin	NOUN
admet-2988	84	14	,	,	PUNCT
admet-2988	84	15	and	and	CCONJ
admet-2988	84	16	various	various	ADJ
admet-2988	84	17	proteoglycans	proteoglycan	NOUN
admet-2988	84	18	,	,	PUNCT
admet-2988	84	19	which	which	PRON
admet-2988	84	20	are	be	AUX
admet-2988	84	21	synthesized	synthesize	VERB
admet-2988	84	22	and	and	CCONJ
admet-2988	84	23	deposited	deposit	VERB
admet-2988	84	24	by	by	ADP
admet-2988	84	25	ecs	ec	NOUN
admet-2988	84	26	,	,	PUNCT
admet-2988	84	27	pericytes	pericyte	NOUN
admet-2988	84	28	,	,	PUNCT
admet-2988	84	29	and	and	CCONJ
admet-2988	84	30	astrocytes	astrocyte	VERB
admet-2988	84	31	[	[	X
admet-2988	84	32	27,43	27,43	X
admet-2988	84	33	]	]	X
admet-2988	84	34	.	.	PUNCT
admet-2988	85	1	the	the	DET
admet-2988	85	2	composition	composition	NOUN
admet-2988	85	3	and	and	CCONJ
admet-2988	85	4	structural	structural	ADJ
admet-2988	85	5	integrity	integrity	NOUN
admet-2988	85	6	of	of	ADP
admet-2988	85	7	the	the	DET
admet-2988	85	8	bl	bl	PROPN
admet-2988	85	9	are	be	AUX
admet-2988	85	10	significantly	significantly	ADV
admet-2988	85	11	altered	alter	VERB
admet-2988	85	12	in	in	ADP
admet-2988	85	13	both	both	CCONJ
admet-2988	85	14	acute	acute	ADJ
admet-2988	85	15	and	and	CCONJ
admet-2988	85	16	chronic	chronic	ADJ
admet-2988	85	17	neuropathological	neuropathological	ADJ
admet-2988	85	18	conditions	condition	NOUN
admet-2988	86	1	[	[	X
admet-2988	86	2	44,45	44,45	X
admet-2988	86	3	]	]	PUNCT
admet-2988	86	4	.	.	PUNCT
admet-2988	87	1	endogenous	endogenous	ADJ
admet-2988	87	2	transport	transport	NOUN
admet-2988	87	3	mechanisms	mechanism	NOUN
admet-2988	87	4	across	across	ADP
admet-2988	87	5	the	the	DET
admet-2988	87	6	bbb	bbb	NOUN
admet-2988	87	7	the	the	DET
admet-2988	87	8	brain	brain	NOUN
admet-2988	87	9	has	have	VERB
admet-2988	87	10	a	a	DET
admet-2988	87	11	high	high	ADJ
admet-2988	87	12	metabolic	metabolic	NOUN
admet-2988	87	13	demand	demand	NOUN
admet-2988	87	14	,	,	PUNCT
admet-2988	87	15	requiring	require	VERB
admet-2988	87	16	various	various	ADJ
admet-2988	87	17	transport	transport	NOUN
admet-2988	87	18	pathways	pathway	NOUN
admet-2988	87	19	to	to	PART
admet-2988	87	20	supply	supply	VERB
admet-2988	87	21	essential	essential	ADJ
admet-2988	87	22	nutrients	nutrient	NOUN
admet-2988	87	23	and	and	CCONJ
admet-2988	87	24	maintain	maintain	VERB
admet-2988	87	25	homeostasis	homeostasis	NOUN
admet-2988	87	26	[	[	X
admet-2988	87	27	29,46	29,46	NOUN
admet-2988	87	28	]	]	PUNCT
admet-2988	87	29	.	.	PUNCT
admet-2988	88	1	across	across	ADP
admet-2988	88	2	the	the	DET
admet-2988	88	3	bbb	bbb	PROPN
admet-2988	88	4	,	,	PUNCT
admet-2988	88	5	which	which	PRON
admet-2988	88	6	serves	serve	VERB
admet-2988	88	7	as	as	ADP
admet-2988	88	8	a	a	DET
admet-2988	88	9	dynamic	dynamic	ADJ
admet-2988	88	10	interface	interface	NOUN
admet-2988	88	11	that	that	PRON
admet-2988	88	12	regulates	regulate	VERB
admet-2988	88	13	both	both	DET
admet-2988	88	14	nutrient	nutrient	NOUN
admet-2988	88	15	influx	influx	NOUN
admet-2988	88	16	and	and	CCONJ
admet-2988	88	17	metabolic	metabolic	NOUN
admet-2988	88	18	waste	waste	NOUN
admet-2988	88	19	removal	removal	NOUN
admet-2988	88	20	,	,	PUNCT
admet-2988	88	21	essential	essential	ADJ
admet-2988	88	22	biomolecules	biomolecule	NOUN
admet-2988	88	23	and	and	CCONJ
admet-2988	88	24	immune	immune	ADJ
admet-2988	88	25	cells	cell	NOUN
admet-2988	88	26	are	be	AUX
admet-2988	88	27	transported	transport	VERB
admet-2988	88	28	to	to	PART
admet-2988	88	29	maintain	maintain	VERB
admet-2988	88	30	proper	proper	ADJ
admet-2988	88	31	brain	brain	NOUN
admet-2988	88	32	function	function	NOUN
admet-2988	88	33	and	and	CCONJ
admet-2988	88	34	systemic	systemic	ADJ
admet-2988	88	35	coordination	coordination	NOUN
admet-2988	88	36	[	[	X
admet-2988	88	37	27,34,47	27,34,47	NUM
admet-2988	88	38	-	-	SYM
admet-2988	88	39	49	49	NUM
admet-2988	88	40	]	]	PUNCT
admet-2988	88	41	.	.	PUNCT
admet-2988	89	1	these	these	DET
admet-2988	89	2	essential	essential	ADJ
admet-2988	89	3	exchanges	exchange	NOUN
admet-2988	89	4	occur	occur	VERB
admet-2988	89	5	via	via	ADP
admet-2988	89	6	transport	transport	NOUN
admet-2988	89	7	mechanisms	mechanism	NOUN
admet-2988	89	8	broadly	broadly	ADV
admet-2988	89	9	classified	classify	VERB
admet-2988	89	10	into	into	ADP
admet-2988	89	11	two	two	NUM
admet-2988	89	12	main	main	ADJ
admet-2988	89	13	categories	category	NOUN
admet-2988	89	14	:	:	PUNCT
admet-2988	89	15	paracellular	paracellular	ADJ
admet-2988	89	16	diffusion	diffusion	NOUN
admet-2988	89	17	and	and	CCONJ
admet-2988	89	18	transcellular	transcellular	NOUN
admet-2988	89	19	transport	transport	NOUN
admet-2988	89	20	,	,	PUNCT
admet-2988	89	21	which	which	PRON
admet-2988	89	22	includes	include	VERB
admet-2988	89	23	passive	passive	ADJ
admet-2988	89	24	,	,	PUNCT
admet-2988	89	25	carrier	carrier	NOUN
admet-2988	89	26	-	-	PUNCT
admet-2988	89	27	mediated	mediate	VERB
admet-2988	89	28	,	,	PUNCT
admet-2988	89	29	receptormediated	receptormediate	VERB
admet-2988	89	30	,	,	PUNCT
admet-2988	89	31	adsorptive	adsorptive	ADJ
admet-2988	89	32	-	-	PUNCT
admet-2988	89	33	mediated	mediate	VERB
admet-2988	89	34	,	,	PUNCT
admet-2988	89	35	and	and	CCONJ
admet-2988	89	36	cell	cell	NOUN
admet-2988	89	37	-	-	PUNCT
admet-2988	89	38	mediated	mediate	VERB
admet-2988	89	39	transcytosis	transcytosis	NOUN
admet-2988	90	1	[	[	X
admet-2988	90	2	29,46	29,46	NOUN
admet-2988	90	3	]	]	PUNCT
admet-2988	90	4	.	.	PUNCT
admet-2988	91	1	figure	figure	NOUN
admet-2988	91	2	3	3	NUM
admet-2988	91	3	provides	provide	VERB
admet-2988	91	4	a	a	DET
admet-2988	91	5	schematic	schematic	ADJ
admet-2988	91	6	overview	overview	NOUN
admet-2988	91	7	of	of	ADP
admet-2988	91	8	these	these	DET
admet-2988	91	9	transport	transport	NOUN
admet-2988	91	10	mechanisms	mechanism	NOUN
admet-2988	91	11	within	within	ADP
admet-2988	91	12	the	the	DET
admet-2988	91	13	nvu	nvu	NOUN
admet-2988	91	14	.	.	PUNCT
admet-2988	92	1	it	it	PRON
admet-2988	92	2	is	be	AUX
admet-2988	92	3	important	important	ADJ
admet-2988	92	4	to	to	PART
admet-2988	92	5	note	note	VERB
admet-2988	92	6	that	that	SCONJ
admet-2988	92	7	additional	additional	ADJ
admet-2988	92	8	endocytic	endocytic	ADJ
admet-2988	92	9	transport	transport	NOUN
admet-2988	92	10	systems	system	NOUN
admet-2988	92	11	,	,	PUNCT
admet-2988	92	12	which	which	PRON
admet-2988	92	13	have	have	AUX
admet-2988	92	14	not	not	PART
admet-2988	92	15	yet	yet	ADV
admet-2988	92	16	been	be	AUX
admet-2988	92	17	fully	fully	ADV
admet-2988	92	18	characterized	characterize	VERB
admet-2988	92	19	,	,	PUNCT
admet-2988	92	20	are	be	AUX
admet-2988	92	21	also	also	ADV
admet-2988	92	22	suggested	suggest	VERB
admet-2988	92	23	to	to	PART
admet-2988	92	24	contribute	contribute	VERB
admet-2988	92	25	to	to	ADP
admet-2988	92	26	regulating	regulate	VERB
admet-2988	92	27	bbb	bbb	PROPN
admet-2988	92	28	permeability	permeability	NOUN
admet-2988	92	29	[	[	X
admet-2988	92	30	50	50	NUM
admet-2988	92	31	]	]	PUNCT
admet-2988	92	32	.	.	PUNCT
admet-2988	93	1	figure	figure	NOUN
admet-2988	93	2	3	3	NUM
admet-2988	93	3	.	.	PUNCT
admet-2988	93	4	transport	transport	NOUN
admet-2988	93	5	routes	route	NOUN
admet-2988	93	6	across	across	ADP
admet-2988	93	7	the	the	DET
admet-2988	93	8	bbb	bbb	PROPN
admet-2988	93	9	.	.	PUNCT
admet-2988	94	1	schematic	schematic	ADJ
admet-2988	94	2	representation	representation	NOUN
admet-2988	94	3	of	of	ADP
admet-2988	94	4	the	the	DET
admet-2988	94	5	primary	primary	ADJ
admet-2988	94	6	transport	transport	NOUN
admet-2988	94	7	mechanisms	mechanism	NOUN
admet-2988	94	8	regulating	regulate	VERB
admet-2988	94	9	molecular	molecular	ADJ
admet-2988	94	10	exchange	exchange	NOUN
admet-2988	94	11	at	at	ADP
admet-2988	94	12	the	the	DET
admet-2988	94	13	blood	blood	NOUN
admet-2988	94	14	-	-	PUNCT
admet-2988	94	15	brain	brain	NOUN
admet-2988	94	16	barrier	barrier	NOUN
admet-2988	94	17	.	.	PUNCT
admet-2988	95	1	these	these	PRON
admet-2988	95	2	include	include	VERB
admet-2988	95	3	(	(	PUNCT
admet-2988	95	4	i	i	NOUN
admet-2988	95	5	)	)	PUNCT
admet-2988	95	6	paracellular	paracellular	ADJ
admet-2988	95	7	diffusion	diffusion	NOUN
admet-2988	95	8	,	,	PUNCT
admet-2988	95	9	(	(	PUNCT
admet-2988	95	10	ii	ii	NOUN
admet-2988	95	11	)	)	PUNCT
admet-2988	95	12	transcellular	transcellular	ADJ
admet-2988	95	13	lipophilic	lipophilic	ADJ
admet-2988	95	14	diffusion	diffusion	NOUN
admet-2988	95	15	,	,	PUNCT
admet-2988	95	16	(	(	PUNCT
admet-2988	95	17	iii	iii	NOUN
admet-2988	95	18	)	)	PUNCT
admet-2988	95	19	carrier	carrier	NOUN
admet-2988	95	20	-	-	PUNCT
admet-2988	95	21	mediated	mediate	VERB
admet-2988	95	22	transport	transport	NOUN
admet-2988	95	23	,	,	PUNCT
admet-2988	95	24	(	(	PUNCT
admet-2988	95	25	iv	iv	X
admet-2988	95	26	)	)	PUNCT
admet-2988	95	27	efflux	efflux	NOUN
admet-2988	95	28	pumps	pump	NOUN
admet-2988	95	29	,	,	PUNCT
admet-2988	95	30	(	(	PUNCT
admet-2988	95	31	v	v	NOUN
admet-2988	95	32	)	)	PUNCT
admet-2988	95	33	receptor	receptor	NOUN
admet-2988	95	34	-	-	PUNCT
admet-2988	95	35	mediated	mediate	VERB
admet-2988	95	36	transcytosis	transcytosis	NOUN
admet-2988	95	37	,	,	PUNCT
admet-2988	95	38	(	(	PUNCT
admet-2988	95	39	vi	vi	NOUN
admet-2988	95	40	)	)	PUNCT
admet-2988	95	41	adsorptive	adsorptive	ADJ
admet-2988	95	42	transcytosis	transcytosis	NOUN
admet-2988	95	43	,	,	PUNCT
admet-2988	95	44	and	and	CCONJ
admet-2988	95	45	(	(	PUNCT
admet-2988	95	46	vii	vii	PROPN
admet-2988	95	47	)	)	PUNCT
admet-2988	95	48	cell	cell	NOUN
admet-2988	95	49	-	-	PUNCT
admet-2988	95	50	mediated	mediate	VERB
admet-2988	95	51	transcytosis	transcytosis	NOUN
admet-2988	95	52	.	.	PUNCT
admet-2988	96	1	adapted	adapt	VERB
admet-2988	96	2	from	from	ADP
admet-2988	96	3	[	[	X
admet-2988	96	4	5	5	NUM
admet-2988	96	5	]	]	PUNCT
admet-2988	96	6	cc	cc	NOUN
admet-2988	96	7	by	by	ADP
admet-2988	96	8	4.0	4.0	NUM
admet-2988	96	9	.	.	PUNCT
admet-2988	97	1	paracellular	paracellular	ADJ
admet-2988	97	2	diffusion	diffusion	NOUN
admet-2988	97	3	paracellular	paracellular	ADJ
admet-2988	97	4	diffusion	diffusion	NOUN
admet-2988	97	5	(	(	PUNCT
admet-2988	97	6	figure	figure	NOUN
admet-2988	97	7	3	3	NUM
admet-2988	97	8	-	-	PUNCT
admet-2988	97	9	i	i	NOUN
admet-2988	97	10	)	)	PUNCT
admet-2988	97	11	refers	refer	VERB
admet-2988	97	12	to	to	ADP
admet-2988	97	13	the	the	DET
admet-2988	97	14	passive	passive	ADJ
admet-2988	97	15	movement	movement	NOUN
admet-2988	97	16	of	of	ADP
admet-2988	97	17	substances	substance	NOUN
admet-2988	97	18	through	through	ADP
admet-2988	97	19	the	the	DET
admet-2988	97	20	intercellular	intercellular	ADJ
admet-2988	97	21	space	space	NOUN
admet-2988	97	22	between	between	ADP
admet-2988	97	23	adjacent	adjacent	ADJ
admet-2988	97	24	ecs	ecs	PROPN
admet-2988	98	1	[	[	X
admet-2988	98	2	51	51	NUM
admet-2988	98	3	]	]	PUNCT
admet-2988	98	4	.	.	PUNCT
admet-2988	99	1	this	this	DET
admet-2988	99	2	non	non	ADJ
admet-2988	99	3	-	-	ADJ
admet-2988	99	4	specific	specific	ADJ
admet-2988	99	5	transport	transport	NOUN
admet-2988	99	6	is	be	AUX
admet-2988	99	7	driven	drive	VERB
admet-2988	99	8	by	by	ADP
admet-2988	99	9	concentration	concentration	NOUN
admet-2988	99	10	gradients	gradient	NOUN
admet-2988	99	11	from	from	ADP
admet-2988	99	12	the	the	DET
admet-2988	99	13	bloodstream	bloodstream	NOUN
admet-2988	99	14	into	into	ADP
admet-2988	99	15	the	the	DET
admet-2988	99	16	brain	brain	NOUN
admet-2988	99	17	and	and	CCONJ
admet-2988	99	18	is	be	AUX
admet-2988	99	19	restricted	restrict	VERB
admet-2988	99	20	to	to	ADP
admet-2988	99	21	water	water	NOUN
admet-2988	99	22	-	-	PUNCT
admet-2988	99	23	soluble	soluble	ADJ
admet-2988	99	24	,	,	PUNCT
admet-2988	99	25	non	non	ADJ
admet-2988	99	26	-	-	ADJ
admet-2988	99	27	ionised	ionised	ADJ
admet-2988	99	28	molecules	molecule	NOUN
admet-2988	99	29	with	with	ADP
admet-2988	99	30	a	a	DET
admet-2988	99	31	molecular	molecular	ADJ
admet-2988	99	32	weight	weight	NOUN
admet-2988	99	33	below	below	ADP
admet-2988	99	34	500	500	NUM
admet-2988	99	35	da	da	X
admet-2988	100	1	[	[	X
admet-2988	100	2	29	29	NUM
admet-2988	100	3	]	]	PUNCT
admet-2988	100	4	.	.	PUNCT
admet-2988	101	1	tjs	tjs	NOUN
admet-2988	101	2	play	play	VERB
admet-2988	101	3	a	a	DET
admet-2988	101	4	crucial	crucial	ADJ
admet-2988	101	5	role	role	NOUN
admet-2988	101	6	in	in	ADP
admet-2988	101	7	regulating	regulate	VERB
admet-2988	101	8	this	this	DET
admet-2988	101	9	pathway	pathway	NOUN
admet-2988	101	10	[	[	X
admet-2988	101	11	27	27	NUM
admet-2988	101	12	]	]	PUNCT
admet-2988	101	13	,	,	PUNCT
admet-2988	101	14	as	as	SCONJ
admet-2988	101	15	structural	structural	ADJ
admet-2988	101	16	changes	change	NOUN
admet-2988	101	17	in	in	ADP
admet-2988	101	18	their	their	PRON
admet-2988	101	19	composition	composition	NOUN
admet-2988	101	20	have	have	AUX
admet-2988	101	21	been	be	AUX
admet-2988	101	22	observed	observe	VERB
admet-2988	101	23	to	to	PART
admet-2988	101	24	increase	increase	VERB
admet-2988	101	25	the	the	DET
admet-2988	101	26	molecular	molecular	ADJ
admet-2988	101	27	weight	weight	NOUN
admet-2988	101	28	threshold	threshold	NOUN
admet-2988	101	29	for	for	ADP
admet-2988	101	30	substances	substance	NOUN
admet-2988	101	31	crossing	cross	VERB
admet-2988	101	32	the	the	DET
admet-2988	101	33	bbb	bbb	NOUN
admet-2988	101	34	via	via	ADP
admet-2988	101	35	paracellular	paracellular	ADJ
admet-2988	101	36	diffusion	diffusion	NOUN
admet-2988	102	1	[	[	X
admet-2988	102	2	52	52	NUM
admet-2988	102	3	]	]	PUNCT
admet-2988	102	4	.	.	PUNCT
admet-2988	103	1	transcellular	transcellular	NOUN
admet-2988	103	2	diffusion	diffusion	NOUN
admet-2988	103	3	transcellular	transcellular	NOUN
admet-2988	103	4	diffusion	diffusion	NOUN
admet-2988	103	5	,	,	PUNCT
admet-2988	103	6	also	also	ADV
admet-2988	103	7	known	know	VERB
admet-2988	103	8	as	as	ADP
admet-2988	103	9	passive	passive	ADJ
admet-2988	103	10	transcytosis	transcytosis	NOUN
admet-2988	103	11	(	(	PUNCT
admet-2988	103	12	figure	figure	NOUN
admet-2988	103	13	3	3	NUM
admet-2988	103	14	-	-	PUNCT
admet-2988	103	15	ii	ii	NOUN
admet-2988	103	16	)	)	PUNCT
admet-2988	103	17	,	,	PUNCT
admet-2988	103	18	allows	allow	VERB
admet-2988	103	19	the	the	DET
admet-2988	103	20	non	non	ADJ
admet-2988	103	21	-	-	ADJ
admet-2988	103	22	specific	specific	ADJ
admet-2988	103	23	passage	passage	NOUN
admet-2988	103	24	of	of	ADP
admet-2988	103	25	small	small	ADJ
admet-2988	103	26	,	,	PUNCT
admet-2988	103	27	lipophilic	lipophilic	ADJ
admet-2988	103	28	,	,	PUNCT
admet-2988	103	29	and	and	CCONJ
admet-2988	103	30	non	non	ADJ
admet-2988	103	31	-	-	ADJ
admet-2988	103	32	ionised	ionised	ADJ
admet-2988	103	33	molecules	molecule	NOUN
admet-2988	103	34	directly	directly	ADV
admet-2988	103	35	across	across	ADP
admet-2988	103	36	the	the	DET
admet-2988	103	37	ecs	ecs	PROPN
admet-2988	103	38	,	,	PUNCT
admet-2988	103	39	driven	drive	VERB
admet-2988	103	40	by	by	ADP
admet-2988	103	41	concentration	concentration	NOUN
admet-2988	103	42	gradients	gradient	NOUN
admet-2988	103	43	[	[	X
admet-2988	103	44	29	29	NUM
admet-2988	103	45	]	]	PUNCT
admet-2988	103	46	.	.	PUNCT
admet-2988	104	1	ethanol	ethanol	NOUN
admet-2988	104	2	and	and	CCONJ
admet-2988	104	3	steroid	steroid	NOUN
admet-2988	104	4	hormones	hormone	NOUN
admet-2988	104	5	are	be	AUX
admet-2988	104	6	common	common	ADJ
admet-2988	104	7	examples	example	NOUN
admet-2988	104	8	of	of	ADP
admet-2988	104	9	molecules	molecule	NOUN
admet-2988	104	10	utilizing	utilize	VERB
admet-2988	104	11	this	this	DET
admet-2988	104	12	pathway	pathway	NOUN
admet-2988	104	13	,	,	PUNCT
admet-2988	104	14	which	which	PRON
admet-2988	104	15	can	can	AUX
admet-2988	104	16	dissolve	dissolve	VERB
admet-2988	104	17	into	into	ADP
admet-2988	104	18	the	the	DET
admet-2988	104	19	plasma	plasma	NOUN
admet-2988	104	20	membrane	membrane	NOUN
admet-2988	104	21	of	of	ADP
admet-2988	104	22	ecs	ecs	PROPN
admet-2988	105	1	[	[	X
admet-2988	105	2	46	46	NUM
admet-2988	105	3	]	]	PUNCT
admet-2988	105	4	.	.	PUNCT
admet-2988	106	1	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	106	2	r.	r.	PROPN
admet-2988	106	3	vargas	vargas	PROPN
admet-2988	106	4	et	et	PROPN
admet-2988	106	5	al	al	PROPN
admet-2988	106	6	.	.	PROPN
admet-2988	106	7	admet	admet	PROPN
admet-2988	106	8	&	&	CCONJ
admet-2988	106	9	dmpk	dmpk	PROPN
admet-2988	106	10	13(5	13(5	NUM
admet-2988	106	11	)	)	PUNCT
admet-2988	106	12	(	(	PUNCT
admet-2988	106	13	2025	2025	NUM
admet-2988	106	14	)	)	PUNCT
admet-2988	106	15	2988	2988	NUM
admet-2988	106	16	6	6	NUM
admet-2988	106	17	carrier	carrier	NOUN
admet-2988	106	18	-	-	PUNCT
admet-2988	106	19	mediated	mediate	VERB
admet-2988	106	20	transcytosis	transcytosis	NOUN
admet-2988	106	21	carrier	carrier	NOUN
admet-2988	106	22	-	-	PUNCT
admet-2988	106	23	mediated	mediate	VERB
admet-2988	106	24	transport	transport	NOUN
admet-2988	106	25	involves	involve	VERB
admet-2988	106	26	specific	specific	ADJ
admet-2988	106	27	transporter	transporter	NOUN
admet-2988	106	28	proteins	protein	NOUN
admet-2988	106	29	,	,	PUNCT
admet-2988	106	30	such	such	ADJ
admet-2988	106	31	as	as	ADP
admet-2988	106	32	glut-1	glut-1	PROPN
admet-2988	106	33	for	for	ADP
admet-2988	106	34	glucose	glucose	NOUN
admet-2988	106	35	and	and	CCONJ
admet-2988	106	36	lat	lat	NOUN
admet-2988	106	37	transporters	transporter	NOUN
admet-2988	106	38	for	for	ADP
admet-2988	106	39	large	large	ADJ
admet-2988	106	40	neutral	neutral	ADJ
admet-2988	106	41	amino	amino	ADJ
admet-2988	106	42	acids	acid	NOUN
admet-2988	106	43	[	[	X
admet-2988	106	44	29	29	NUM
admet-2988	106	45	]	]	PUNCT
admet-2988	106	46	.	.	PUNCT
admet-2988	107	1	as	as	SCONJ
admet-2988	107	2	shown	show	VERB
admet-2988	107	3	in	in	ADP
admet-2988	107	4	figure	figure	NOUN
admet-2988	107	5	3	3	NUM
admet-2988	107	6	-	-	PUNCT
admet-2988	107	7	iii	iii	NOUN
admet-2988	107	8	,	,	PUNCT
admet-2988	107	9	this	this	DET
admet-2988	107	10	mechanism	mechanism	NOUN
admet-2988	107	11	operates	operate	VERB
admet-2988	107	12	when	when	SCONJ
admet-2988	107	13	a	a	DET
admet-2988	107	14	substrate	substrate	NOUN
admet-2988	107	15	binds	bind	VERB
admet-2988	107	16	to	to	ADP
admet-2988	107	17	its	its	PRON
admet-2988	107	18	transporter	transporter	NOUN
admet-2988	107	19	on	on	ADP
admet-2988	107	20	the	the	DET
admet-2988	107	21	luminal	luminal	ADJ
admet-2988	107	22	side	side	NOUN
admet-2988	107	23	of	of	ADP
admet-2988	107	24	the	the	DET
admet-2988	107	25	bbb	bbb	NOUN
admet-2988	107	26	,	,	PUNCT
admet-2988	107	27	inducing	induce	VERB
admet-2988	107	28	conformational	conformational	ADJ
admet-2988	107	29	changes	change	NOUN
admet-2988	107	30	in	in	ADP
admet-2988	107	31	the	the	DET
admet-2988	107	32	transporter	transporter	NOUN
admet-2988	107	33	that	that	PRON
admet-2988	107	34	facilitate	facilitate	VERB
admet-2988	107	35	its	its	PRON
admet-2988	107	36	release	release	NOUN
admet-2988	107	37	into	into	ADP
admet-2988	107	38	the	the	DET
admet-2988	107	39	brain	brain	NOUN
admet-2988	107	40	parenchyma	parenchyma	NOUN
admet-2988	107	41	[	[	X
admet-2988	107	42	46	46	NUM
admet-2988	107	43	]	]	PUNCT
admet-2988	107	44	.	.	PUNCT
admet-2988	108	1	this	this	DET
admet-2988	108	2	system	system	NOUN
admet-2988	108	3	also	also	ADV
admet-2988	108	4	mediates	mediate	VERB
admet-2988	108	5	the	the	DET
admet-2988	108	6	transport	transport	NOUN
admet-2988	108	7	of	of	ADP
admet-2988	108	8	vitamins	vitamin	NOUN
admet-2988	108	9	,	,	PUNCT
admet-2988	108	10	organic	organic	ADJ
admet-2988	108	11	ions	ion	NOUN
admet-2988	108	12	,	,	PUNCT
admet-2988	108	13	hormones	hormone	NOUN
admet-2988	108	14	,	,	PUNCT
admet-2988	108	15	nucleosides	nucleoside	NOUN
admet-2988	108	16	,	,	PUNCT
admet-2988	108	17	and	and	CCONJ
admet-2988	108	18	fatty	fatty	ADJ
admet-2988	108	19	acids	acid	NOUN
admet-2988	108	20	[	[	X
admet-2988	108	21	27	27	NUM
admet-2988	108	22	]	]	PUNCT
admet-2988	108	23	.	.	PUNCT
admet-2988	109	1	it	it	PRON
admet-2988	109	2	is	be	AUX
admet-2988	109	3	an	an	DET
admet-2988	109	4	active	active	ADJ
admet-2988	109	5	and	and	CCONJ
admet-2988	109	6	selective	selective	ADJ
admet-2988	109	7	process	process	NOUN
admet-2988	109	8	that	that	PRON
admet-2988	109	9	may	may	AUX
admet-2988	109	10	be	be	AUX
admet-2988	109	11	atp	atp	NOUN
admet-2988	109	12	-	-	PUNCT
admet-2988	109	13	dependent	dependent	ADJ
admet-2988	109	14	,	,	PUNCT
admet-2988	109	15	enabling	enable	VERB
admet-2988	109	16	the	the	DET
admet-2988	109	17	movement	movement	NOUN
admet-2988	109	18	of	of	ADP
admet-2988	109	19	substances	substance	NOUN
admet-2988	109	20	against	against	ADP
admet-2988	109	21	concentration	concentration	NOUN
admet-2988	109	22	gradients	gradient	NOUN
admet-2988	109	23	[	[	X
admet-2988	109	24	46	46	NUM
admet-2988	109	25	]	]	PUNCT
admet-2988	109	26	.	.	PUNCT
admet-2988	110	1	receptor	receptor	NOUN
admet-2988	110	2	-	-	PUNCT
admet-2988	110	3	mediated	mediate	VERB
admet-2988	110	4	transcytosis	transcytosis	NOUN
admet-2988	110	5	receptor	receptor	NOUN
admet-2988	110	6	-	-	PUNCT
admet-2988	110	7	mediated	mediate	VERB
admet-2988	110	8	transcytosis	transcytosis	NOUN
admet-2988	110	9	(	(	PUNCT
admet-2988	110	10	figure	figure	NOUN
admet-2988	110	11	3	3	NUM
admet-2988	110	12	-	-	PUNCT
admet-2988	110	13	v	v	NOUN
admet-2988	110	14	)	)	PUNCT
admet-2988	110	15	facilitates	facilitate	VERB
admet-2988	110	16	the	the	DET
admet-2988	110	17	transport	transport	NOUN
admet-2988	110	18	of	of	ADP
admet-2988	110	19	endogenous	endogenous	ADJ
admet-2988	110	20	macromolecules	macromolecule	NOUN
admet-2988	110	21	such	such	ADJ
admet-2988	110	22	as	as	ADP
admet-2988	110	23	insulin	insulin	NOUN
admet-2988	110	24	,	,	PUNCT
admet-2988	110	25	transferrin	transferrin	NOUN
admet-2988	110	26	,	,	PUNCT
admet-2988	110	27	leptin	leptin	NOUN
admet-2988	110	28	,	,	PUNCT
admet-2988	110	29	vasopressin	vasopressin	NOUN
admet-2988	110	30	and	and	CCONJ
admet-2988	110	31	lipoproteins	lipoprotein	NOUN
admet-2988	110	32	across	across	ADP
admet-2988	110	33	the	the	DET
admet-2988	110	34	bbb	bbb	NOUN
admet-2988	111	1	[	[	X
admet-2988	111	2	27,51	27,51	X
admet-2988	111	3	]	]	X
admet-2988	111	4	.	.	PUNCT
admet-2988	112	1	unlike	unlike	ADP
admet-2988	112	2	the	the	DET
admet-2988	112	3	conformational	conformational	ADJ
admet-2988	112	4	changes	change	NOUN
admet-2988	112	5	observed	observe	VERB
admet-2988	112	6	in	in	ADP
admet-2988	112	7	carrier	carrier	NOUN
admet-2988	112	8	-	-	PUNCT
admet-2988	112	9	mediated	mediate	VERB
admet-2988	112	10	transport	transport	NOUN
admet-2988	112	11	,	,	PUNCT
admet-2988	112	12	this	this	DET
admet-2988	112	13	mechanism	mechanism	NOUN
admet-2988	112	14	is	be	AUX
admet-2988	112	15	initiated	initiate	VERB
admet-2988	112	16	when	when	SCONJ
admet-2988	112	17	a	a	DET
admet-2988	112	18	ligand	ligand	NOUN
admet-2988	112	19	binds	bind	VERB
admet-2988	112	20	to	to	ADP
admet-2988	112	21	its	its	PRON
admet-2988	112	22	specific	specific	ADJ
admet-2988	112	23	receptor	receptor	NOUN
admet-2988	112	24	,	,	PUNCT
admet-2988	112	25	triggering	trigger	VERB
admet-2988	112	26	membrane	membrane	NOUN
admet-2988	112	27	invagination	invagination	NOUN
admet-2988	112	28	and	and	CCONJ
admet-2988	112	29	the	the	DET
admet-2988	112	30	formation	formation	NOUN
admet-2988	112	31	of	of	ADP
admet-2988	112	32	intracellular	intracellular	ADJ
admet-2988	112	33	vesicles	vesicle	NOUN
admet-2988	112	34	known	know	VERB
admet-2988	112	35	as	as	ADP
admet-2988	112	36	endosomes	endosome	NOUN
admet-2988	112	37	.	.	PUNCT
admet-2988	113	1	once	once	ADV
admet-2988	113	2	internalized	internalize	VERB
admet-2988	113	3	,	,	PUNCT
admet-2988	113	4	these	these	PRON
admet-2988	113	5	endosomes	endosome	VERB
admet-2988	113	6	undergo	undergo	VERB
admet-2988	113	7	acidification	acidification	NOUN
admet-2988	113	8	,	,	PUNCT
admet-2988	113	9	leading	lead	VERB
admet-2988	113	10	to	to	ADP
admet-2988	113	11	the	the	DET
admet-2988	113	12	dissociation	dissociation	NOUN
admet-2988	113	13	of	of	ADP
admet-2988	113	14	the	the	DET
admet-2988	113	15	ligand	ligand	NOUN
admet-2988	113	16	from	from	ADP
admet-2988	113	17	its	its	PRON
admet-2988	113	18	receptor	receptor	NOUN
admet-2988	113	19	and	and	CCONJ
admet-2988	113	20	subsequent	subsequent	ADJ
admet-2988	113	21	exocytosis	exocytosis	NOUN
admet-2988	113	22	into	into	ADP
admet-2988	113	23	the	the	DET
admet-2988	113	24	brain	brain	NOUN
admet-2988	114	1	[	[	X
admet-2988	114	2	29,46	29,46	NOUN
admet-2988	114	3	]	]	PUNCT
admet-2988	114	4	.	.	PUNCT
admet-2988	115	1	this	this	DET
admet-2988	115	2	process	process	NOUN
admet-2988	115	3	is	be	AUX
admet-2988	115	4	mediated	mediate	VERB
admet-2988	115	5	by	by	ADP
admet-2988	115	6	specialized	specialized	ADJ
admet-2988	115	7	endocytic	endocytic	ADJ
admet-2988	115	8	structures	structure	NOUN
admet-2988	115	9	,	,	PUNCT
admet-2988	115	10	primarily	primarily	ADV
admet-2988	115	11	clathrinand	clathrinand	ADV
admet-2988	115	12	caveolin	caveolin	NOUN
admet-2988	115	13	-	-	PUNCT
admet-2988	115	14	coated	coat	VERB
admet-2988	115	15	vesicles	vesicle	NOUN
admet-2988	115	16	[	[	X
admet-2988	115	17	50,53	50,53	X
admet-2988	115	18	]	]	PUNCT
admet-2988	115	19	.	.	PUNCT
admet-2988	116	1	adsorptive	adsorptive	ADJ
admet-2988	116	2	-	-	PUNCT
admet-2988	116	3	mediated	mediate	VERB
admet-2988	116	4	transcytosis	transcytosis	NOUN
admet-2988	116	5	adsorptive	adsorptive	ADJ
admet-2988	116	6	-	-	PUNCT
admet-2988	116	7	mediated	mediate	VERB
admet-2988	116	8	transcytosis	transcytosis	NOUN
admet-2988	116	9	(	(	PUNCT
admet-2988	116	10	figure	figure	NOUN
admet-2988	116	11	3	3	NUM
admet-2988	116	12	-	-	PUNCT
admet-2988	116	13	vi	vi	NOUN
admet-2988	116	14	)	)	PUNCT
admet-2988	116	15	,	,	PUNCT
admet-2988	116	16	also	also	ADV
admet-2988	116	17	known	know	VERB
admet-2988	116	18	as	as	ADP
admet-2988	116	19	pinocytosis	pinocytosis	NOUN
admet-2988	116	20	,	,	PUNCT
admet-2988	116	21	is	be	AUX
admet-2988	116	22	a	a	DET
admet-2988	116	23	non	non	ADJ
admet-2988	116	24	-	-	ADJ
admet-2988	116	25	specific	specific	ADJ
admet-2988	116	26	transport	transport	NOUN
admet-2988	116	27	mechanism	mechanism	NOUN
admet-2988	116	28	triggered	trigger	VERB
admet-2988	116	29	by	by	ADP
admet-2988	116	30	electrostatic	electrostatic	ADJ
admet-2988	116	31	interactions	interaction	NOUN
admet-2988	116	32	between	between	ADP
admet-2988	116	33	positively	positively	ADV
admet-2988	116	34	charged	charge	VERB
admet-2988	116	35	molecules	molecule	NOUN
admet-2988	116	36	and	and	CCONJ
admet-2988	116	37	negatively	negatively	ADV
admet-2988	116	38	charged	charge	VERB
admet-2988	116	39	domains	domain	NOUN
admet-2988	116	40	on	on	ADP
admet-2988	116	41	the	the	DET
admet-2988	116	42	surface	surface	NOUN
admet-2988	116	43	of	of	ADP
admet-2988	116	44	ecs	ecs	PROPN
admet-2988	116	45	[	[	X
admet-2988	116	46	50,54	50,54	NUM
admet-2988	116	47	]	]	PUNCT
admet-2988	116	48	.	.	PUNCT
admet-2988	117	1	although	although	SCONJ
admet-2988	117	2	this	this	DET
admet-2988	117	3	pathway	pathway	NOUN
admet-2988	117	4	exhibits	exhibit	VERB
admet-2988	117	5	lower	low	ADJ
admet-2988	117	6	ligand	ligand	ADJ
admet-2988	117	7	specificity	specificity	NOUN
admet-2988	117	8	compared	compare	VERB
admet-2988	117	9	to	to	ADP
admet-2988	117	10	receptor	receptor	NOUN
admet-2988	117	11	-	-	PUNCT
admet-2988	117	12	mediated	mediate	VERB
admet-2988	117	13	transcytosis	transcytosis	NOUN
admet-2988	117	14	,	,	PUNCT
admet-2988	117	15	it	it	PRON
admet-2988	117	16	offers	offer	VERB
admet-2988	117	17	a	a	DET
admet-2988	117	18	higher	high	ADJ
admet-2988	117	19	transport	transport	NOUN
admet-2988	117	20	capacity	capacity	NOUN
admet-2988	117	21	[	[	X
admet-2988	117	22	46	46	NUM
admet-2988	117	23	]	]	PUNCT
admet-2988	117	24	.	.	PUNCT
admet-2988	118	1	it	it	PRON
admet-2988	118	2	plays	play	VERB
admet-2988	118	3	a	a	DET
admet-2988	118	4	critical	critical	ADJ
admet-2988	118	5	role	role	NOUN
admet-2988	118	6	in	in	ADP
admet-2988	118	7	the	the	DET
admet-2988	118	8	transport	transport	NOUN
admet-2988	118	9	of	of	ADP
admet-2988	118	10	certain	certain	ADJ
admet-2988	118	11	plasma	plasma	NOUN
admet-2988	118	12	macromolecules	macromolecule	NOUN
admet-2988	118	13	,	,	PUNCT
admet-2988	118	14	including	include	VERB
admet-2988	118	15	albumin	albumin	NOUN
admet-2988	118	16	and	and	CCONJ
admet-2988	118	17	heparin	heparin	NOUN
admet-2988	118	18	-	-	PUNCT
admet-2988	118	19	derived	derive	VERB
admet-2988	118	20	proteoglycans	proteoglycan	NOUN
admet-2988	118	21	[	[	X
admet-2988	118	22	46,54	46,54	NUM
admet-2988	118	23	]	]	PUNCT
admet-2988	118	24	.	.	PUNCT
admet-2988	119	1	cell	cell	NOUN
admet-2988	119	2	-	-	PUNCT
admet-2988	119	3	mediated	mediate	VERB
admet-2988	119	4	transcytosis	transcytosis	NOUN
admet-2988	119	5	cell	cell	NOUN
admet-2988	119	6	-	-	PUNCT
admet-2988	119	7	mediated	mediate	VERB
admet-2988	119	8	transcytosis	transcytosis	NOUN
admet-2988	119	9	(	(	PUNCT
admet-2988	119	10	figure	figure	NOUN
admet-2988	119	11	3	3	NUM
admet-2988	119	12	-	-	PUNCT
admet-2988	119	13	vii	vii	NOUN
admet-2988	119	14	)	)	PUNCT
admet-2988	119	15	is	be	AUX
admet-2988	119	16	the	the	DET
admet-2988	119	17	most	most	ADV
admet-2988	119	18	recently	recently	ADV
admet-2988	119	19	described	describe	VERB
admet-2988	119	20	transport	transport	NOUN
admet-2988	119	21	mechanism	mechanism	NOUN
admet-2988	119	22	across	across	ADP
admet-2988	119	23	the	the	DET
admet-2988	119	24	bbb	bbb	NOUN
admet-2988	120	1	[	[	X
admet-2988	120	2	46	46	NUM
admet-2988	120	3	]	]	PUNCT
admet-2988	120	4	.	.	PUNCT
admet-2988	121	1	this	this	DET
admet-2988	121	2	pathway	pathway	NOUN
admet-2988	121	3	allows	allow	VERB
admet-2988	121	4	immune	immune	ADJ
admet-2988	121	5	cells	cell	NOUN
admet-2988	121	6	,	,	PUNCT
admet-2988	121	7	including	include	VERB
admet-2988	121	8	neutrophils	neutrophil	NOUN
admet-2988	121	9	,	,	PUNCT
admet-2988	121	10	monocytes	monocyte	NOUN
admet-2988	121	11	and	and	CCONJ
admet-2988	121	12	macrophages	macrophage	NOUN
admet-2988	121	13	,	,	PUNCT
admet-2988	121	14	to	to	PART
admet-2988	121	15	cross	cross	VERB
admet-2988	121	16	the	the	DET
admet-2988	121	17	bbb	bbb	NOUN
admet-2988	121	18	under	under	ADP
admet-2988	121	19	both	both	CCONJ
admet-2988	121	20	physiological	physiological	ADJ
admet-2988	121	21	and	and	CCONJ
admet-2988	121	22	pathological	pathological	ADJ
admet-2988	121	23	conditions	condition	NOUN
admet-2988	121	24	[	[	X
admet-2988	121	25	29	29	NUM
admet-2988	121	26	]	]	PUNCT
admet-2988	121	27	.	.	PUNCT
admet-2988	122	1	it	it	PRON
admet-2988	122	2	has	have	AUX
admet-2988	122	3	been	be	AUX
admet-2988	122	4	implicated	implicate	VERB
admet-2988	122	5	in	in	ADP
admet-2988	122	6	the	the	DET
admet-2988	122	7	infiltration	infiltration	NOUN
admet-2988	122	8	of	of	ADP
admet-2988	122	9	pathogens	pathogen	NOUN
admet-2988	122	10	,	,	PUNCT
admet-2988	122	11	including	include	VERB
admet-2988	122	12	viruses	virus	NOUN
admet-2988	122	13	,	,	PUNCT
admet-2988	122	14	fungi	fungus	NOUN
admet-2988	122	15	and	and	CCONJ
admet-2988	122	16	bacteria	bacteria	NOUN
admet-2988	122	17	,	,	PUNCT
admet-2988	122	18	into	into	ADP
admet-2988	122	19	the	the	DET
admet-2988	122	20	cns	cns	NOUN
admet-2988	122	21	,	,	PUNCT
admet-2988	122	22	earning	earn	VERB
admet-2988	122	23	its	its	PRON
admet-2988	122	24	designation	designation	NOUN
admet-2988	122	25	as	as	ADP
admet-2988	122	26	the	the	DET
admet-2988	122	27	“	"	PUNCT
admet-2988	122	28	trojan	trojan	NOUN
admet-2988	122	29	horse	horse	NOUN
admet-2988	122	30	”	"	PUNCT
admet-2988	122	31	mechanism	mechanism	NOUN
admet-2988	122	32	[	[	X
admet-2988	122	33	46,55,56	46,55,56	NOUN
admet-2988	122	34	]	]	PUNCT
admet-2988	122	35	.	.	PUNCT
admet-2988	123	1	efflux	efflux	PROPN
admet-2988	123	2	pumps	pump	NOUN
admet-2988	123	3	efflux	efflux	NOUN
admet-2988	123	4	pumps	pump	NOUN
admet-2988	123	5	(	(	PUNCT
admet-2988	123	6	figure	figure	NOUN
admet-2988	123	7	3	3	NUM
admet-2988	123	8	-	-	SYM
admet-2988	123	9	iv	iv	NOUN
admet-2988	123	10	)	)	PUNCT
admet-2988	123	11	actively	actively	ADV
admet-2988	123	12	transport	transport	VERB
admet-2988	123	13	molecules	molecule	NOUN
admet-2988	123	14	out	out	ADP
admet-2988	123	15	of	of	ADP
admet-2988	123	16	the	the	DET
admet-2988	123	17	brain	brain	NOUN
admet-2988	123	18	,	,	PUNCT
admet-2988	123	19	preventing	prevent	VERB
admet-2988	123	20	their	their	PRON
admet-2988	123	21	accumulation	accumulation	NOUN
admet-2988	123	22	within	within	ADP
admet-2988	123	23	the	the	DET
admet-2988	123	24	cns	cns	NOUN
admet-2988	123	25	.	.	PUNCT
admet-2988	124	1	these	these	DET
admet-2988	124	2	atp	atp	NOUN
admet-2988	124	3	-	-	PUNCT
admet-2988	124	4	dependent	dependent	ADJ
admet-2988	124	5	transporters	transporter	NOUN
admet-2988	124	6	,	,	PUNCT
admet-2988	124	7	including	include	VERB
admet-2988	124	8	p	p	NOUN
admet-2988	124	9	-	-	PUNCT
admet-2988	124	10	gp	gp	NOUN
admet-2988	124	11	and	and	CCONJ
admet-2988	124	12	multidrug	multidrug	VERB
admet-2988	124	13	resistance	resistance	NOUN
admet-2988	124	14	proteins	protein	NOUN
admet-2988	124	15	[	[	X
admet-2988	124	16	46	46	NUM
admet-2988	124	17	]	]	PUNCT
admet-2988	124	18	,	,	PUNCT
admet-2988	124	19	play	play	VERB
admet-2988	124	20	a	a	DET
admet-2988	124	21	critical	critical	ADJ
admet-2988	124	22	role	role	NOUN
admet-2988	124	23	in	in	ADP
admet-2988	124	24	maintaining	maintain	VERB
admet-2988	124	25	bbb	bbb	NOUN
admet-2988	124	26	integrity	integrity	NOUN
admet-2988	124	27	by	by	ADP
admet-2988	124	28	removing	remove	VERB
admet-2988	124	29	exogenous	exogenous	ADJ
admet-2988	124	30	substances	substance	NOUN
admet-2988	124	31	and	and	CCONJ
admet-2988	124	32	metabolic	metabolic	NOUN
admet-2988	124	33	products	product	NOUN
admet-2988	124	34	[	[	X
admet-2988	124	35	27	27	NUM
admet-2988	124	36	]	]	PUNCT
admet-2988	124	37	.	.	PUNCT
admet-2988	125	1	efflux	efflux	PROPN
admet-2988	125	2	can	can	AUX
admet-2988	125	3	also	also	ADV
admet-2988	125	4	reduce	reduce	VERB
admet-2988	125	5	the	the	DET
admet-2988	125	6	effectiveness	effectiveness	NOUN
admet-2988	125	7	of	of	ADP
admet-2988	125	8	certain	certain	ADJ
admet-2988	125	9	drugs	drug	NOUN
admet-2988	125	10	by	by	ADP
admet-2988	125	11	limiting	limit	VERB
admet-2988	125	12	the	the	DET
admet-2988	125	13	accumulation	accumulation	NOUN
admet-2988	125	14	of	of	ADP
admet-2988	125	15	compounds	compound	NOUN
admet-2988	125	16	that	that	PRON
admet-2988	125	17	manage	manage	VERB
admet-2988	125	18	to	to	PART
admet-2988	125	19	cross	cross	VERB
admet-2988	125	20	the	the	DET
admet-2988	125	21	bbb	bbb	NOUN
admet-2988	126	1	[	[	X
admet-2988	126	2	28	28	NUM
admet-2988	126	3	]	]	PUNCT
admet-2988	126	4	.	.	PUNCT
admet-2988	127	1	therapeutic	therapeutic	ADJ
admet-2988	127	2	limitations	limitation	NOUN
admet-2988	127	3	imposed	impose	VERB
admet-2988	127	4	by	by	ADP
admet-2988	127	5	the	the	DET
admet-2988	127	6	blood	blood	NOUN
admet-2988	127	7	-	-	PUNCT
admet-2988	127	8	brain	brain	NOUN
admet-2988	127	9	barrier	barrier	NOUN
admet-2988	127	10	:	:	PUNCT
admet-2988	127	11	implications	implication	NOUN
admet-2988	127	12	for	for	ADP
admet-2988	127	13	central	central	ADJ
admet-2988	127	14	nervous	nervous	ADJ
admet-2988	127	15	system	system	NOUN
admet-2988	127	16	drug	drug	NOUN
admet-2988	127	17	development	development	NOUN
admet-2988	127	18	the	the	DET
admet-2988	127	19	permeability	permeability	NOUN
admet-2988	127	20	and	and	CCONJ
admet-2988	127	21	structural	structural	ADJ
admet-2988	127	22	characteristics	characteristic	NOUN
admet-2988	127	23	of	of	ADP
admet-2988	127	24	the	the	DET
admet-2988	127	25	bbb	bbb	PROPN
admet-2988	127	26	pose	pose	VERB
admet-2988	127	27	significant	significant	ADJ
admet-2988	127	28	challenges	challenge	NOUN
admet-2988	127	29	for	for	ADP
admet-2988	127	30	drug	drug	NOUN
admet-2988	127	31	delivery	delivery	NOUN
admet-2988	127	32	to	to	ADP
admet-2988	127	33	the	the	DET
admet-2988	127	34	brain	brain	NOUN
admet-2988	127	35	.	.	PUNCT
admet-2988	128	1	despite	despite	SCONJ
admet-2988	128	2	substantial	substantial	ADJ
admet-2988	128	3	advances	advance	NOUN
admet-2988	128	4	in	in	ADP
admet-2988	128	5	biomedical	biomedical	ADJ
admet-2988	128	6	science	science	NOUN
admet-2988	128	7	,	,	PUNCT
admet-2988	128	8	the	the	DET
admet-2988	128	9	availability	availability	NOUN
admet-2988	128	10	of	of	ADP
admet-2988	128	11	pharmacological	pharmacological	ADJ
admet-2988	128	12	treatments	treatment	NOUN
admet-2988	128	13	for	for	ADP
admet-2988	128	14	cns	cns	NOUN
admet-2988	128	15	disorders	disorder	NOUN
admet-2988	128	16	remains	remain	VERB
admet-2988	128	17	limited	limited	ADJ
admet-2988	128	18	due	due	ADP
admet-2988	128	19	to	to	ADP
admet-2988	128	20	the	the	DET
admet-2988	128	21	inability	inability	NOUN
admet-2988	128	22	of	of	ADP
admet-2988	128	23	many	many	ADJ
admet-2988	128	24	drugs	drug	NOUN
admet-2988	128	25	to	to	PART
admet-2988	128	26	cross	cross	VERB
admet-2988	128	27	the	the	DET
admet-2988	128	28	bbb	bbb	NOUN
admet-2988	128	29	or	or	CCONJ
admet-2988	128	30	to	to	PART
admet-2988	128	31	accumulate	accumulate	VERB
admet-2988	128	32	at	at	ADP
admet-2988	128	33	therapeutic	therapeutic	ADJ
admet-2988	128	34	concentrations	concentration	NOUN
admet-2988	128	35	within	within	ADP
admet-2988	128	36	the	the	DET
admet-2988	128	37	brain	brain	NOUN
admet-2988	128	38	tissue	tissue	NOUN
admet-2988	129	1	[	[	X
admet-2988	129	2	45,57	45,57	ADP
admet-2988	129	3	]	]	PUNCT
admet-2988	129	4	.	.	PUNCT
admet-2988	130	1	admet	admet	PROPN
admet-2988	130	2	&	&	CCONJ
admet-2988	130	3	dmpk	dmpk	PROPN
admet-2988	130	4	13(5	13(5	NUM
admet-2988	130	5	)	)	PUNCT
admet-2988	130	6	(	(	PUNCT
admet-2988	130	7	2025	2025	NUM
admet-2988	130	8	)	)	PUNCT
admet-2988	130	9	2988	2988	NUM
admet-2988	130	10	advancing	advance	VERB
admet-2988	130	11	through	through	ADP
admet-2988	130	12	the	the	DET
admet-2988	130	13	blood	blood	NOUN
admet-2988	130	14	-	-	PUNCT
admet-2988	130	15	brain	brain	NOUN
admet-2988	130	16	barrier	barrier	NOUN
admet-2988	130	17	doi	doi	NOUN
admet-2988	130	18	:	:	PUNCT
admet-2988	130	19	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	130	20	7	7	NUM
admet-2988	130	21	in	in	ADP
admet-2988	130	22	most	most	ADJ
admet-2988	130	23	cases	case	NOUN
admet-2988	130	24	,	,	PUNCT
admet-2988	130	25	the	the	DET
admet-2988	130	26	bbb	bbb	NOUN
admet-2988	130	27	either	either	CCONJ
admet-2988	130	28	completely	completely	ADV
admet-2988	130	29	prevents	prevent	VERB
admet-2988	130	30	drug	drug	NOUN
admet-2988	130	31	accumulation	accumulation	NOUN
admet-2988	130	32	in	in	ADP
admet-2988	130	33	the	the	DET
admet-2988	130	34	brain	brain	NOUN
admet-2988	130	35	or	or	CCONJ
admet-2988	130	36	requires	require	VERB
admet-2988	130	37	the	the	DET
admet-2988	130	38	administration	administration	NOUN
admet-2988	130	39	of	of	ADP
admet-2988	130	40	excessively	excessively	ADV
admet-2988	130	41	high	high	ADJ
admet-2988	130	42	doses	dose	NOUN
admet-2988	130	43	to	to	PART
admet-2988	130	44	achieve	achieve	VERB
admet-2988	130	45	therapeutic	therapeutic	ADJ
admet-2988	130	46	concentrations	concentration	NOUN
admet-2988	130	47	,	,	PUNCT
admet-2988	130	48	increasing	increase	VERB
admet-2988	130	49	the	the	DET
admet-2988	130	50	risk	risk	NOUN
admet-2988	130	51	of	of	ADP
admet-2988	130	52	systemic	systemic	ADJ
admet-2988	130	53	toxicity	toxicity	NOUN
admet-2988	130	54	[	[	X
admet-2988	130	55	58,59	58,59	NUM
admet-2988	130	56	]	]	PUNCT
admet-2988	130	57	.	.	PUNCT
admet-2988	131	1	it	it	PRON
admet-2988	131	2	is	be	AUX
admet-2988	131	3	estimated	estimate	VERB
admet-2988	131	4	that	that	SCONJ
admet-2988	131	5	the	the	DET
admet-2988	131	6	bbb	bbb	NOUN
admet-2988	131	7	excludes	exclude	VERB
admet-2988	131	8	approximately	approximately	ADV
admet-2988	131	9	98	98	NUM
admet-2988	131	10	%	%	NOUN
admet-2988	131	11	of	of	ADP
admet-2988	131	12	small	small	ADJ
admet-2988	131	13	-	-	PUNCT
admet-2988	131	14	molecule	molecule	NOUN
admet-2988	131	15	drugs	drug	NOUN
admet-2988	131	16	and	and	CCONJ
admet-2988	131	17	nearly	nearly	ADV
admet-2988	131	18	all	all	PRON
admet-2988	131	19	biomolecules	biomolecule	NOUN
admet-2988	131	20	,	,	PUNCT
admet-2988	131	21	including	include	VERB
admet-2988	131	22	proteins	protein	NOUN
admet-2988	131	23	,	,	PUNCT
admet-2988	131	24	peptides	peptide	NOUN
admet-2988	131	25	,	,	PUNCT
admet-2988	131	26	nucleic	nucleic	ADJ
admet-2988	131	27	acids	acid	NOUN
admet-2988	131	28	,	,	PUNCT
admet-2988	131	29	antibodies	antibodie	VERB
admet-2988	131	30	,	,	PUNCT
admet-2988	131	31	and	and	CCONJ
admet-2988	131	32	viral	viral	ADJ
admet-2988	131	33	vectors	vector	NOUN
admet-2988	131	34	[	[	X
admet-2988	131	35	27	27	NUM
admet-2988	131	36	]	]	PUNCT
admet-2988	131	37	.	.	PUNCT
admet-2988	132	1	cns	cns	PROPN
admet-2988	132	2	disorders	disorder	NOUN
admet-2988	132	3	place	place	VERB
admet-2988	132	4	an	an	DET
admet-2988	132	5	increasing	increase	VERB
admet-2988	132	6	economic	economic	ADJ
admet-2988	132	7	burden	burden	NOUN
admet-2988	132	8	on	on	ADP
admet-2988	132	9	healthcare	healthcare	NOUN
admet-2988	132	10	systems	system	NOUN
admet-2988	132	11	[	[	X
admet-2988	132	12	60,61	60,61	NOUN
admet-2988	132	13	]	]	PUNCT
admet-2988	132	14	,	,	PUNCT
admet-2988	132	15	currently	currently	ADV
admet-2988	132	16	accounting	account	VERB
admet-2988	132	17	for	for	ADP
admet-2988	132	18	approximately	approximately	ADV
admet-2988	132	19	6.3	6.3	NUM
admet-2988	132	20	%	%	NOUN
admet-2988	132	21	of	of	ADP
admet-2988	132	22	the	the	DET
admet-2988	132	23	global	global	ADJ
admet-2988	132	24	disease	disease	NOUN
admet-2988	132	25	burden	burden	NOUN
admet-2988	132	26	[	[	X
admet-2988	132	27	21	21	NUM
admet-2988	132	28	]	]	PUNCT
admet-2988	132	29	.	.	PUNCT
admet-2988	133	1	in	in	ADP
admet-2988	133	2	addition	addition	NOUN
admet-2988	133	3	,	,	PUNCT
admet-2988	133	4	increasing	increase	VERB
admet-2988	133	5	life	life	NOUN
admet-2988	133	6	expectancy	expectancy	NOUN
admet-2988	133	7	and	and	CCONJ
admet-2988	133	8	the	the	DET
admet-2988	133	9	resulting	result	VERB
admet-2988	133	10	ageing	ageing	NOUN
admet-2988	133	11	of	of	ADP
admet-2988	133	12	the	the	DET
admet-2988	133	13	population	population	NOUN
admet-2988	133	14	suggest	suggest	VERB
admet-2988	133	15	that	that	SCONJ
admet-2988	133	16	the	the	DET
admet-2988	133	17	epidemiological	epidemiological	ADJ
admet-2988	133	18	impact	impact	NOUN
admet-2988	133	19	of	of	ADP
admet-2988	133	20	neurodegenerative	neurodegenerative	ADJ
admet-2988	133	21	diseases	disease	NOUN
admet-2988	133	22	,	,	PUNCT
admet-2988	133	23	which	which	PRON
admet-2988	133	24	typically	typically	ADV
admet-2988	133	25	manifest	manifest	VERB
admet-2988	133	26	between	between	ADP
admet-2988	133	27	the	the	DET
admet-2988	133	28	ages	age	NOUN
admet-2988	133	29	of	of	ADP
admet-2988	133	30	50	50	NUM
admet-2988	133	31	and	and	CCONJ
admet-2988	133	32	70	70	NUM
admet-2988	133	33	,	,	PUNCT
admet-2988	133	34	will	will	AUX
admet-2988	133	35	continue	continue	VERB
admet-2988	133	36	to	to	PART
admet-2988	133	37	rise	rise	VERB
admet-2988	133	38	.	.	PUNCT
admet-2988	134	1	as	as	ADP
admet-2988	134	2	a	a	DET
admet-2988	134	3	result	result	NOUN
admet-2988	134	4	,	,	PUNCT
admet-2988	134	5	pressure	pressure	NOUN
admet-2988	134	6	on	on	ADP
admet-2988	134	7	healthcare	healthcare	NOUN
admet-2988	134	8	systems	system	NOUN
admet-2988	134	9	is	be	AUX
admet-2988	134	10	expected	expect	VERB
admet-2988	134	11	to	to	PART
admet-2988	134	12	increase	increase	VERB
admet-2988	134	13	,	,	PUNCT
admet-2988	134	14	highlighting	highlight	VERB
admet-2988	134	15	the	the	DET
admet-2988	134	16	urgent	urgent	ADJ
admet-2988	134	17	need	need	NOUN
admet-2988	134	18	for	for	ADP
admet-2988	134	19	effective	effective	ADJ
admet-2988	134	20	therapeutic	therapeutic	ADJ
admet-2988	134	21	strategies	strategy	NOUN
admet-2988	134	22	to	to	PART
admet-2988	134	23	treat	treat	VERB
admet-2988	134	24	cns	cns	NOUN
admet-2988	134	25	disorders	disorder	NOUN
admet-2988	134	26	[	[	X
admet-2988	134	27	62,63	62,63	NOUN
admet-2988	134	28	]	]	PUNCT
admet-2988	134	29	.	.	PUNCT
admet-2988	135	1	many	many	ADJ
admet-2988	135	2	major	major	ADJ
admet-2988	135	3	pharmaceutical	pharmaceutical	ADJ
admet-2988	135	4	companies	company	NOUN
admet-2988	135	5	allocate	allocate	VERB
admet-2988	135	6	limited	limited	ADJ
admet-2988	135	7	resources	resource	NOUN
admet-2988	135	8	to	to	ADP
admet-2988	135	9	cns	cns	PROPN
admet-2988	135	10	drug	drug	NOUN
admet-2988	135	11	development	development	NOUN
admet-2988	135	12	,	,	PUNCT
admet-2988	135	13	primarily	primarily	ADV
admet-2988	135	14	due	due	ADP
admet-2988	135	15	to	to	ADP
admet-2988	135	16	the	the	DET
admet-2988	135	17	high	high	ADJ
admet-2988	135	18	costs	cost	NOUN
admet-2988	135	19	,	,	PUNCT
admet-2988	135	20	prolonged	prolonged	ADJ
admet-2988	135	21	timelines	timeline	NOUN
admet-2988	135	22	,	,	PUNCT
admet-2988	135	23	and	and	CCONJ
admet-2988	135	24	low	low	ADJ
admet-2988	135	25	success	success	NOUN
admet-2988	135	26	rates	rate	NOUN
admet-2988	135	27	associated	associate	VERB
admet-2988	135	28	with	with	ADP
admet-2988	135	29	the	the	DET
admet-2988	135	30	clinical	clinical	ADJ
admet-2988	135	31	translation	translation	NOUN
admet-2988	135	32	of	of	ADP
admet-2988	135	33	these	these	DET
admet-2988	135	34	therapies	therapy	NOUN
admet-2988	135	35	[	[	X
admet-2988	135	36	60,64,65	60,64,65	NUM
admet-2988	135	37	]	]	PUNCT
admet-2988	135	38	.	.	PUNCT
admet-2988	136	1	moreover	moreover	ADV
admet-2988	136	2	,	,	PUNCT
admet-2988	136	3	the	the	DET
admet-2988	136	4	development	development	NOUN
admet-2988	136	5	of	of	ADP
admet-2988	136	6	cns	cns	NOUN
admet-2988	136	7	-	-	PUNCT
admet-2988	136	8	targeted	target	VERB
admet-2988	136	9	therapies	therapy	NOUN
admet-2988	136	10	is	be	AUX
admet-2988	136	11	additionally	additionally	ADV
admet-2988	136	12	constrained	constrain	VERB
admet-2988	136	13	by	by	ADP
admet-2988	136	14	significant	significant	ADJ
admet-2988	136	15	challenges	challenge	NOUN
admet-2988	136	16	,	,	PUNCT
admet-2988	136	17	including	include	VERB
admet-2988	136	18	an	an	DET
admet-2988	136	19	incomplete	incomplete	ADJ
admet-2988	136	20	understanding	understanding	NOUN
admet-2988	136	21	of	of	ADP
admet-2988	136	22	the	the	DET
admet-2988	136	23	underlying	underlie	VERB
admet-2988	136	24	pathophysiology	pathophysiology	NOUN
admet-2988	136	25	of	of	ADP
admet-2988	136	26	many	many	ADJ
admet-2988	136	27	neurological	neurological	ADJ
admet-2988	136	28	disorders	disorder	NOUN
admet-2988	136	29	,	,	PUNCT
admet-2988	136	30	the	the	DET
admet-2988	136	31	complexity	complexity	NOUN
admet-2988	136	32	of	of	ADP
admet-2988	136	33	defining	define	VERB
admet-2988	136	34	reliable	reliable	ADJ
admet-2988	136	35	clinical	clinical	ADJ
admet-2988	136	36	endpoints	endpoint	NOUN
admet-2988	136	37	,	,	PUNCT
admet-2988	136	38	and	and	CCONJ
admet-2988	136	39	the	the	DET
admet-2988	136	40	formidable	formidable	ADJ
admet-2988	136	41	barrier	barrier	NOUN
admet-2988	136	42	posed	pose	VERB
admet-2988	136	43	by	by	ADP
admet-2988	136	44	the	the	DET
admet-2988	136	45	bbb	bbb	PROPN
admet-2988	137	1	[	[	X
admet-2988	137	2	64	64	NUM
admet-2988	137	3	]	]	PUNCT
admet-2988	137	4	.	.	PUNCT
admet-2988	138	1	developing	develop	VERB
admet-2988	138	2	innovative	innovative	ADJ
admet-2988	138	3	tools	tool	NOUN
admet-2988	138	4	to	to	PART
admet-2988	138	5	overcome	overcome	VERB
admet-2988	138	6	the	the	DET
admet-2988	138	7	challenges	challenge	NOUN
admet-2988	138	8	of	of	ADP
admet-2988	138	9	drug	drug	NOUN
admet-2988	138	10	delivery	delivery	NOUN
admet-2988	138	11	to	to	ADP
admet-2988	138	12	the	the	DET
admet-2988	138	13	brain	brain	NOUN
admet-2988	138	14	is	be	AUX
admet-2988	138	15	essential	essential	ADJ
admet-2988	138	16	for	for	ADP
admet-2988	138	17	expanding	expand	VERB
admet-2988	138	18	therapeutic	therapeutic	ADJ
admet-2988	138	19	options	option	NOUN
admet-2988	138	20	for	for	ADP
admet-2988	138	21	cns	cns	NOUN
admet-2988	138	22	disorders	disorder	NOUN
admet-2988	138	23	[	[	X
admet-2988	138	24	60	60	NUM
admet-2988	138	25	]	]	PUNCT
admet-2988	138	26	.	.	PUNCT
admet-2988	139	1	recognizing	recognize	VERB
admet-2988	139	2	the	the	DET
admet-2988	139	3	bbb	bbb	NOUN
admet-2988	139	4	not	not	PART
admet-2988	139	5	only	only	ADV
admet-2988	139	6	as	as	ADP
admet-2988	139	7	an	an	DET
admet-2988	139	8	obstacle	obstacle	NOUN
admet-2988	139	9	but	but	CCONJ
admet-2988	139	10	also	also	ADV
admet-2988	139	11	as	as	ADP
admet-2988	139	12	a	a	DET
admet-2988	139	13	potential	potential	ADJ
admet-2988	139	14	path	path	NOUN
admet-2988	139	15	for	for	ADP
admet-2988	139	16	therapeutic	therapeutic	ADJ
admet-2988	139	17	delivery	delivery	NOUN
admet-2988	139	18	highlights	highlight	NOUN
admet-2988	139	19	the	the	DET
admet-2988	139	20	need	need	NOUN
admet-2988	139	21	for	for	ADP
admet-2988	139	22	continued	continue	VERB
admet-2988	139	23	research	research	NOUN
admet-2988	139	24	and	and	CCONJ
admet-2988	139	25	a	a	DET
admet-2988	139	26	deeper	deep	ADJ
admet-2988	139	27	understanding	understanding	NOUN
admet-2988	139	28	of	of	ADP
admet-2988	139	29	its	its	PRON
admet-2988	139	30	mechanisms	mechanism	NOUN
admet-2988	139	31	.	.	PUNCT
admet-2988	140	1	harnessing	harness	VERB
admet-2988	140	2	its	its	PRON
admet-2988	140	3	endogenous	endogenous	ADJ
admet-2988	140	4	transport	transport	NOUN
admet-2988	140	5	mechanisms	mechanism	NOUN
admet-2988	140	6	may	may	AUX
admet-2988	140	7	pave	pave	VERB
admet-2988	140	8	the	the	DET
admet-2988	140	9	way	way	NOUN
admet-2988	140	10	for	for	ADP
admet-2988	140	11	innovative	innovative	ADJ
admet-2988	140	12	drug	drug	NOUN
admet-2988	140	13	delivery	delivery	NOUN
admet-2988	140	14	systems	system	NOUN
admet-2988	140	15	that	that	PRON
admet-2988	140	16	improve	improve	VERB
admet-2988	140	17	therapeutic	therapeutic	ADJ
admet-2988	140	18	access	access	NOUN
admet-2988	140	19	to	to	ADP
admet-2988	140	20	the	the	DET
admet-2988	140	21	cns	cns	NOUN
admet-2988	140	22	.	.	PUNCT
admet-2988	141	1	optimizing	optimize	VERB
admet-2988	141	2	therapeutic	therapeutic	ADJ
admet-2988	141	3	access	access	NOUN
admet-2988	141	4	to	to	ADP
admet-2988	141	5	the	the	DET
admet-2988	141	6	brain	brain	NOUN
admet-2988	141	7	:	:	PUNCT
admet-2988	141	8	strategies	strategy	NOUN
admet-2988	141	9	to	to	PART
admet-2988	141	10	overcome	overcome	VERB
admet-2988	141	11	the	the	DET
admet-2988	141	12	blood	blood	NOUN
admet-2988	141	13	-	-	PUNCT
admet-2988	141	14	brain	brain	NOUN
admet-2988	141	15	barrier	barrier	NOUN
admet-2988	141	16	the	the	DET
admet-2988	141	17	development	development	NOUN
admet-2988	141	18	of	of	ADP
admet-2988	141	19	therapeutic	therapeutic	ADJ
admet-2988	141	20	strategies	strategy	NOUN
admet-2988	141	21	to	to	PART
admet-2988	141	22	facilitate	facilitate	VERB
admet-2988	141	23	drug	drug	NOUN
admet-2988	141	24	delivery	delivery	NOUN
admet-2988	141	25	across	across	ADP
admet-2988	141	26	the	the	DET
admet-2988	141	27	bbb	bbb	PROPN
admet-2988	141	28	is	be	AUX
admet-2988	141	29	an	an	DET
admet-2988	141	30	area	area	NOUN
admet-2988	141	31	of	of	ADP
admet-2988	141	32	considerable	considerable	ADJ
admet-2988	141	33	interest	interest	NOUN
admet-2988	141	34	.	.	PUNCT
admet-2988	142	1	this	this	DET
admet-2988	142	2	research	research	NOUN
admet-2988	142	3	field	field	NOUN
admet-2988	142	4	has	have	AUX
admet-2988	142	5	greatly	greatly	ADV
admet-2988	142	6	benefited	benefit	VERB
admet-2988	142	7	from	from	ADP
admet-2988	142	8	advances	advance	NOUN
admet-2988	142	9	in	in	ADP
admet-2988	142	10	molecular	molecular	ADJ
admet-2988	142	11	biology	biology	NOUN
admet-2988	142	12	and	and	CCONJ
admet-2988	142	13	a	a	DET
admet-2988	142	14	deeper	deep	ADJ
admet-2988	142	15	understanding	understanding	NOUN
admet-2988	142	16	of	of	ADP
admet-2988	142	17	both	both	DET
admet-2988	142	18	barrier	barrier	NOUN
admet-2988	142	19	mechanisms	mechanism	NOUN
admet-2988	142	20	and	and	CCONJ
admet-2988	142	21	cns	cns	NOUN
admet-2988	142	22	pathophysiology	pathophysiology	NOUN
admet-2988	142	23	[	[	X
admet-2988	142	24	46	46	NUM
admet-2988	142	25	]	]	PUNCT
admet-2988	142	26	.	.	PUNCT
admet-2988	143	1	one	one	NUM
admet-2988	143	2	approach	approach	NOUN
admet-2988	143	3	to	to	ADP
admet-2988	143	4	cns	cns	PROPN
admet-2988	143	5	drug	drug	NOUN
admet-2988	143	6	development	development	NOUN
admet-2988	143	7	involves	involve	VERB
admet-2988	143	8	the	the	DET
admet-2988	143	9	synthesis	synthesis	NOUN
admet-2988	143	10	or	or	CCONJ
admet-2988	143	11	structural	structural	ADJ
admet-2988	143	12	modification	modification	NOUN
admet-2988	143	13	of	of	ADP
admet-2988	143	14	small	small	ADJ
admet-2988	143	15	molecules	molecule	NOUN
admet-2988	143	16	to	to	PART
admet-2988	143	17	enhance	enhance	VERB
admet-2988	143	18	their	their	PRON
admet-2988	143	19	ability	ability	NOUN
admet-2988	143	20	to	to	PART
admet-2988	143	21	cross	cross	VERB
admet-2988	143	22	the	the	DET
admet-2988	143	23	bbb	bbb	NOUN
admet-2988	143	24	directly	directly	ADV
admet-2988	143	25	.	.	PUNCT
admet-2988	144	1	the	the	DET
admet-2988	144	2	application	application	NOUN
admet-2988	144	3	of	of	ADP
admet-2988	144	4	lipinski	lipinski	PROPN
admet-2988	144	5	's	's	PART
admet-2988	144	6	rule	rule	NOUN
admet-2988	144	7	of	of	ADP
admet-2988	144	8	five	five	NUM
admet-2988	144	9	,	,	PUNCT
admet-2988	144	10	or	or	CCONJ
admet-2988	144	11	its	its	PRON
admet-2988	144	12	modifications	modification	NOUN
admet-2988	144	13	,	,	PUNCT
admet-2988	144	14	has	have	AUX
admet-2988	144	15	been	be	AUX
admet-2988	144	16	widely	widely	ADV
admet-2988	144	17	used	use	VERB
admet-2988	144	18	as	as	ADP
admet-2988	144	19	a	a	DET
admet-2988	144	20	predictive	predictive	ADJ
admet-2988	144	21	framework	framework	NOUN
admet-2988	144	22	for	for	ADP
admet-2988	144	23	bbb	bbb	PROPN
admet-2988	144	24	permeability	permeability	NOUN
admet-2988	144	25	[	[	X
admet-2988	144	26	27,65,66	27,65,66	NUM
admet-2988	144	27	]	]	PUNCT
admet-2988	144	28	.	.	PUNCT
admet-2988	145	1	according	accord	VERB
admet-2988	145	2	to	to	ADP
admet-2988	145	3	this	this	DET
admet-2988	145	4	rule	rule	NOUN
admet-2988	145	5	,	,	PUNCT
admet-2988	145	6	a	a	DET
admet-2988	145	7	compound	compound	NOUN
admet-2988	145	8	is	be	AUX
admet-2988	145	9	more	more	ADV
admet-2988	145	10	likely	likely	ADJ
admet-2988	145	11	to	to	PART
admet-2988	145	12	cross	cross	VERB
admet-2988	145	13	the	the	DET
admet-2988	145	14	bbb	bbb	NOUN
admet-2988	145	15	,	,	PUNCT
admet-2988	145	16	mainly	mainly	ADV
admet-2988	145	17	by	by	ADP
admet-2988	145	18	transcellular	transcellular	ADJ
admet-2988	145	19	diffusion	diffusion	NOUN
admet-2988	145	20	,	,	PUNCT
admet-2988	145	21	if	if	SCONJ
admet-2988	145	22	it	it	PRON
admet-2988	145	23	meets	meet	VERB
admet-2988	145	24	the	the	DET
admet-2988	145	25	following	follow	VERB
admet-2988	145	26	physicochemical	physicochemical	ADJ
admet-2988	145	27	criteria	criterion	NOUN
admet-2988	145	28	:	:	PUNCT
admet-2988	145	29	i	i	X
admet-2988	145	30	)	)	PUNCT
admet-2988	145	31	molecular	molecular	ADJ
admet-2988	145	32	weight	weight	NOUN
admet-2988	145	33	below	below	ADP
admet-2988	145	34	450	450	NUM
admet-2988	145	35	da	da	PROPN
admet-2988	145	36	,	,	PUNCT
admet-2988	145	37	ii	ii	NOUN
admet-2988	145	38	)	)	PUNCT
admet-2988	145	39	partition	partition	NOUN
admet-2988	145	40	coefficient	coefficient	NOUN
admet-2988	145	41	(	(	PUNCT
admet-2988	145	42	log	log	VERB
admet-2988	145	43	p	p	NOUN
admet-2988	145	44	)	)	PUNCT
admet-2988	145	45	between	between	ADP
admet-2988	145	46	2	2	NUM
admet-2988	145	47	and	and	CCONJ
admet-2988	145	48	4	4	NUM
admet-2988	145	49	,	,	PUNCT
admet-2988	145	50	iii	iii	NOUN
admet-2988	145	51	)	)	PUNCT
admet-2988	145	52	low	low	ADJ
admet-2988	145	53	hydrogen	hydrogen	NOUN
admet-2988	145	54	bond	bond	NOUN
admet-2988	145	55	donor	donor	NOUN
admet-2988	145	56	capacity	capacity	NOUN
admet-2988	145	57	(	(	PUNCT
admet-2988	145	58	fewer	few	ADJ
admet-2988	145	59	than	than	ADP
admet-2988	145	60	10	10	NUM
admet-2988	145	61	hydrogen	hydrogen	NOUN
admet-2988	145	62	bond	bond	NOUN
admet-2988	145	63	donors	donor	NOUN
admet-2988	145	64	per	per	ADP
admet-2988	145	65	molecule	molecule	NOUN
admet-2988	145	66	)	)	PUNCT
admet-2988	145	67	,	,	PUNCT
admet-2988	145	68	and	and	CCONJ
admet-2988	145	69	iv	iv	X
admet-2988	145	70	)	)	PUNCT
admet-2988	145	71	pka	pka	NOUN
admet-2988	145	72	between	between	ADP
admet-2988	145	73	6	6	NUM
admet-2988	145	74	and	and	CCONJ
admet-2988	145	75	10.5	10.5	NUM
admet-2988	145	76	,	,	PUNCT
admet-2988	145	77	ensuring	ensure	VERB
admet-2988	145	78	minimal	minimal	ADJ
admet-2988	145	79	ionisation	ionisation	NOUN
admet-2988	145	80	at	at	ADP
admet-2988	145	81	physiological	physiological	ADJ
admet-2988	145	82	ph	ph	NOUN
admet-2988	145	83	[	[	X
admet-2988	145	84	46,67	46,67	NOUN
admet-2988	145	85	]	]	X
admet-2988	145	86	.	.	PUNCT
admet-2988	146	1	however	however	ADV
admet-2988	146	2	,	,	PUNCT
admet-2988	146	3	not	not	PART
admet-2988	146	4	all	all	DET
admet-2988	146	5	potential	potential	ADJ
admet-2988	146	6	therapeutic	therapeutic	ADJ
admet-2988	146	7	compounds	compound	NOUN
admet-2988	146	8	can	can	AUX
admet-2988	146	9	be	be	AUX
admet-2988	146	10	structurally	structurally	ADV
admet-2988	146	11	modified	modify	VERB
admet-2988	146	12	to	to	PART
admet-2988	146	13	meet	meet	VERB
admet-2988	146	14	these	these	DET
admet-2988	146	15	criteria	criterion	NOUN
admet-2988	147	1	[	[	X
admet-2988	147	2	46,66	46,66	NOUN
admet-2988	147	3	]	]	X
admet-2988	147	4	.	.	PUNCT
admet-2988	148	1	moreover	moreover	ADV
admet-2988	148	2	,	,	PUNCT
admet-2988	148	3	studies	study	NOUN
admet-2988	148	4	have	have	AUX
admet-2988	148	5	shown	show	VERB
admet-2988	148	6	that	that	SCONJ
admet-2988	148	7	over	over	ADP
admet-2988	148	8	one	one	NUM
admet-2988	148	9	-	-	PUNCT
admet-2988	148	10	third	third	NOUN
admet-2988	148	11	of	of	ADP
admet-2988	148	12	compounds	compound	NOUN
admet-2988	148	13	that	that	PRON
admet-2988	148	14	successfully	successfully	ADV
admet-2988	148	15	cross	cross	VERB
admet-2988	148	16	the	the	DET
admet-2988	148	17	bbb	bbb	NOUN
admet-2988	148	18	do	do	AUX
admet-2988	148	19	not	not	PART
admet-2988	148	20	adhere	adhere	VERB
admet-2988	148	21	to	to	ADP
admet-2988	148	22	lipinski	lipinski	PROPN
admet-2988	148	23	's	's	PART
admet-2988	148	24	rule	rule	NOUN
admet-2988	148	25	,	,	PUNCT
admet-2988	148	26	and	and	CCONJ
admet-2988	148	27	that	that	PRON
admet-2988	148	28	log	log	VERB
admet-2988	148	29	p	p	NOUN
admet-2988	148	30	values	value	NOUN
admet-2988	148	31	of	of	ADP
admet-2988	148	32	permeable	permeable	ADJ
admet-2988	148	33	and	and	CCONJ
admet-2988	148	34	non	non	ADJ
admet-2988	148	35	-	-	ADJ
admet-2988	148	36	permeable	permeable	ADJ
admet-2988	148	37	compounds	compound	NOUN
admet-2988	148	38	do	do	AUX
admet-2988	148	39	not	not	PART
admet-2988	148	40	differ	differ	VERB
admet-2988	148	41	significantly	significantly	ADV
admet-2988	148	42	[	[	X
admet-2988	148	43	68	68	NUM
admet-2988	148	44	]	]	PUNCT
admet-2988	148	45	.	.	PUNCT
admet-2988	149	1	therefore	therefore	ADV
admet-2988	149	2	,	,	PUNCT
admet-2988	149	3	relying	rely	VERB
admet-2988	149	4	solely	solely	ADV
admet-2988	149	5	on	on	ADP
admet-2988	149	6	this	this	DET
admet-2988	149	7	approach	approach	NOUN
admet-2988	149	8	is	be	AUX
admet-2988	149	9	insufficient	insufficient	ADJ
admet-2988	149	10	for	for	ADP
admet-2988	149	11	effective	effective	ADJ
admet-2988	149	12	cns	cns	NOUN
admet-2988	149	13	targeting	targeting	NOUN
admet-2988	149	14	.	.	PUNCT
admet-2988	150	1	as	as	ADP
admet-2988	150	2	a	a	DET
admet-2988	150	3	result	result	NOUN
admet-2988	150	4	,	,	PUNCT
admet-2988	150	5	alternative	alternative	ADJ
admet-2988	150	6	strategies	strategy	NOUN
admet-2988	150	7	have	have	AUX
admet-2988	150	8	been	be	AUX
admet-2988	150	9	developed	develop	VERB
admet-2988	150	10	that	that	SCONJ
admet-2988	150	11	leverage	leverage	NOUN
admet-2988	150	12	physical	physical	ADJ
admet-2988	150	13	,	,	PUNCT
admet-2988	150	14	chemical	chemical	NOUN
admet-2988	150	15	,	,	PUNCT
admet-2988	150	16	and	and	CCONJ
admet-2988	150	17	biological	biological	ADJ
admet-2988	150	18	mechanisms	mechanism	NOUN
admet-2988	150	19	to	to	PART
admet-2988	150	20	enhance	enhance	VERB
admet-2988	150	21	drug	drug	NOUN
admet-2988	150	22	transport	transport	NOUN
admet-2988	150	23	across	across	ADP
admet-2988	150	24	the	the	DET
admet-2988	150	25	bbb	bbb	NOUN
admet-2988	151	1	[	[	X
admet-2988	151	2	57,61,65,67,69	57,61,65,67,69	NUM
admet-2988	151	3	-	-	SYM
admet-2988	151	4	71	71	NUM
admet-2988	151	5	]	]	PUNCT
admet-2988	151	6	.	.	PUNCT
admet-2988	152	1	these	these	DET
admet-2988	152	2	strategies	strategy	NOUN
admet-2988	152	3	can	can	AUX
admet-2988	152	4	be	be	AUX
admet-2988	152	5	broadly	broadly	ADV
admet-2988	152	6	classified	classify	VERB
admet-2988	152	7	into	into	ADP
admet-2988	152	8	invasive	invasive	ADJ
admet-2988	152	9	and	and	CCONJ
admet-2988	152	10	non	non	ADJ
admet-2988	152	11	-	-	ADJ
admet-2988	152	12	invasive	invasive	ADJ
admet-2988	152	13	methods	method	NOUN
admet-2988	152	14	,	,	PUNCT
admet-2988	152	15	as	as	SCONJ
admet-2988	152	16	illustrated	illustrate	VERB
admet-2988	152	17	in	in	ADP
admet-2988	152	18	figure	figure	NOUN
admet-2988	152	19	4	4	NUM
admet-2988	152	20	.	.	PUNCT
admet-2988	152	21	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	152	22	r.	r.	PROPN
admet-2988	152	23	vargas	vargas	PROPN
admet-2988	152	24	et	et	PROPN
admet-2988	152	25	al	al	PROPN
admet-2988	152	26	.	.	PROPN
admet-2988	152	27	admet	admet	PROPN
admet-2988	152	28	&	&	CCONJ
admet-2988	152	29	dmpk	dmpk	PROPN
admet-2988	152	30	13(5	13(5	NUM
admet-2988	152	31	)	)	PUNCT
admet-2988	152	32	(	(	PUNCT
admet-2988	152	33	2025	2025	NUM
admet-2988	152	34	)	)	PUNCT
admet-2988	152	35	2988	2988	NUM
admet-2988	152	36	8	8	NUM
admet-2988	152	37	figure	figure	NOUN
admet-2988	152	38	4	4	NUM
admet-2988	152	39	.	.	PUNCT
admet-2988	152	40	classification	classification	NOUN
admet-2988	152	41	of	of	ADP
admet-2988	152	42	methods	method	NOUN
admet-2988	152	43	for	for	ADP
admet-2988	152	44	drug	drug	NOUN
admet-2988	152	45	delivery	delivery	NOUN
admet-2988	152	46	across	across	ADP
admet-2988	152	47	the	the	DET
admet-2988	152	48	bbb	bbb	PROPN
admet-2988	152	49	.	.	PUNCT
admet-2988	153	1	this	this	DET
admet-2988	153	2	figure	figure	NOUN
admet-2988	153	3	presents	present	VERB
admet-2988	153	4	some	some	PRON
admet-2988	153	5	of	of	ADP
admet-2988	153	6	the	the	DET
admet-2988	153	7	most	most	ADV
admet-2988	153	8	used	use	VERB
admet-2988	153	9	strategies	strategy	NOUN
admet-2988	153	10	for	for	ADP
admet-2988	153	11	delivering	deliver	VERB
admet-2988	153	12	therapeutics	therapeutic	NOUN
admet-2988	153	13	to	to	ADP
admet-2988	153	14	the	the	DET
admet-2988	153	15	cns	cns	NOUN
admet-2988	153	16	,	,	PUNCT
admet-2988	153	17	categorized	categorize	VERB
admet-2988	153	18	into	into	ADP
admet-2988	153	19	non	non	ADJ
admet-2988	153	20	-	-	ADJ
admet-2988	153	21	invasive	invasive	ADJ
admet-2988	153	22	and	and	CCONJ
admet-2988	153	23	invasive	invasive	ADJ
admet-2988	153	24	approaches	approach	NOUN
admet-2988	153	25	.	.	PUNCT
admet-2988	154	1	figure	figure	NOUN
admet-2988	154	2	created	create	VERB
admet-2988	154	3	by	by	ADP
admet-2988	154	4	the	the	DET
admet-2988	154	5	authors	author	NOUN
admet-2988	154	6	with	with	ADP
admet-2988	154	7	biorender.com	biorender.com	X
admet-2988	154	8	based	base	VERB
admet-2988	154	9	on	on	ADP
admet-2988	154	10	information	information	NOUN
admet-2988	154	11	compiled	compile	VERB
admet-2988	154	12	from	from	ADP
admet-2988	154	13	several	several	ADJ
admet-2988	154	14	references	reference	NOUN
admet-2988	154	15	included	include	VERB
admet-2988	154	16	in	in	ADP
admet-2988	154	17	this	this	DET
admet-2988	154	18	review	review	NOUN
admet-2988	154	19	invasive	invasive	ADJ
admet-2988	154	20	methods	method	NOUN
admet-2988	154	21	to	to	PART
admet-2988	154	22	overcome	overcome	VERB
admet-2988	154	23	the	the	DET
admet-2988	154	24	limited	limited	ADJ
admet-2988	154	25	accumulation	accumulation	NOUN
admet-2988	154	26	of	of	ADP
admet-2988	154	27	systemically	systemically	ADV
admet-2988	154	28	administered	administer	VERB
admet-2988	154	29	drugs	drug	NOUN
admet-2988	154	30	in	in	ADP
admet-2988	154	31	the	the	DET
admet-2988	154	32	cns	cns	NOUN
admet-2988	154	33	,	,	PUNCT
admet-2988	154	34	some	some	DET
admet-2988	154	35	treatments	treatment	NOUN
admet-2988	154	36	are	be	AUX
admet-2988	154	37	delivered	deliver	VERB
admet-2988	154	38	directly	directly	ADV
admet-2988	154	39	to	to	ADP
admet-2988	154	40	brain	brain	NOUN
admet-2988	154	41	tissue	tissue	NOUN
admet-2988	154	42	through	through	ADP
admet-2988	154	43	either	either	CCONJ
admet-2988	154	44	physical	physical	ADJ
admet-2988	154	45	or	or	CCONJ
admet-2988	154	46	biochemical	biochemical	ADJ
admet-2988	154	47	disruption	disruption	NOUN
admet-2988	154	48	of	of	ADP
admet-2988	154	49	the	the	DET
admet-2988	154	50	bbb	bbb	PROPN
admet-2988	154	51	,	,	PUNCT
admet-2988	154	52	or	or	CCONJ
admet-2988	154	53	by	by	ADP
admet-2988	154	54	implantation	implantation	NOUN
admet-2988	154	55	of	of	ADP
admet-2988	154	56	biodegradable	biodegradable	ADJ
admet-2988	154	57	,	,	PUNCT
admet-2988	154	58	sustained	sustain	VERB
admet-2988	154	59	-	-	PUNCT
admet-2988	154	60	release	release	NOUN
admet-2988	154	61	systems	system	NOUN
admet-2988	154	62	[	[	X
admet-2988	154	63	69	69	NUM
admet-2988	154	64	]	]	PUNCT
admet-2988	154	65	.	.	PUNCT
admet-2988	155	1	these	these	DET
admet-2988	155	2	approaches	approach	NOUN
admet-2988	155	3	are	be	AUX
admet-2988	155	4	particularly	particularly	ADV
admet-2988	155	5	viable	viable	ADJ
admet-2988	155	6	in	in	ADP
admet-2988	155	7	the	the	DET
admet-2988	155	8	context	context	NOUN
admet-2988	155	9	of	of	ADP
admet-2988	155	10	neurosurgical	neurosurgical	ADJ
admet-2988	155	11	interventions	intervention	NOUN
admet-2988	155	12	following	follow	VERB
admet-2988	155	13	malignant	malignant	ADJ
admet-2988	155	14	tumour	tumour	NOUN
admet-2988	155	15	resection	resection	NOUN
admet-2988	155	16	,	,	PUNCT
admet-2988	155	17	or	or	CCONJ
admet-2988	155	18	in	in	ADP
admet-2988	155	19	the	the	DET
admet-2988	155	20	treatment	treatment	NOUN
admet-2988	155	21	of	of	ADP
admet-2988	155	22	subarachnoid	subarachnoid	NOUN
admet-2988	155	23	hemorrhage	hemorrhage	NOUN
admet-2988	155	24	and	and	CCONJ
admet-2988	155	25	traumatic	traumatic	ADJ
admet-2988	155	26	brain	brain	NOUN
admet-2988	155	27	injury	injury	NOUN
admet-2988	155	28	[	[	X
admet-2988	155	29	60	60	NUM
admet-2988	155	30	]	]	PUNCT
admet-2988	155	31	.	.	PUNCT
admet-2988	156	1	blood	blood	NOUN
admet-2988	156	2	-	-	PUNCT
admet-2988	156	3	brain	brain	NOUN
admet-2988	156	4	barrier	barrier	NOUN
admet-2988	156	5	disruption	disruption	NOUN
admet-2988	156	6	bbb	bbb	NOUN
admet-2988	156	7	disruption	disruption	NOUN
admet-2988	156	8	methods	method	NOUN
admet-2988	156	9	temporarily	temporarily	ADV
admet-2988	156	10	increase	increase	VERB
admet-2988	156	11	barrier	barrier	NOUN
admet-2988	156	12	permeability	permeability	NOUN
admet-2988	156	13	by	by	ADP
admet-2988	156	14	compromising	compromise	VERB
admet-2988	156	15	the	the	DET
admet-2988	156	16	integrity	integrity	NOUN
admet-2988	156	17	of	of	ADP
admet-2988	156	18	ecs	ecs	PROPN
admet-2988	156	19	or	or	CCONJ
admet-2988	156	20	tjs	tjs	NOUN
admet-2988	156	21	,	,	PUNCT
admet-2988	156	22	using	use	VERB
admet-2988	156	23	either	either	CCONJ
admet-2988	156	24	chemical	chemical	ADJ
admet-2988	156	25	agents	agent	NOUN
admet-2988	156	26	or	or	CCONJ
admet-2988	156	27	physical	physical	ADJ
admet-2988	156	28	stimuli	stimulus	NOUN
admet-2988	156	29	.	.	PUNCT
admet-2988	157	1	chemical	chemical	ADJ
admet-2988	157	2	disruption	disruption	NOUN
admet-2988	157	3	involves	involve	VERB
admet-2988	157	4	the	the	DET
admet-2988	157	5	administration	administration	NOUN
admet-2988	157	6	of	of	ADP
admet-2988	157	7	compounds	compound	NOUN
admet-2988	157	8	such	such	ADJ
admet-2988	157	9	as	as	ADP
admet-2988	157	10	mannitol	mannitol	NOUN
admet-2988	157	11	,	,	PUNCT
admet-2988	157	12	ethanol	ethanol	NOUN
admet-2988	157	13	,	,	PUNCT
admet-2988	157	14	hyperosmotic	hyperosmotic	ADJ
admet-2988	157	15	solutions	solution	NOUN
admet-2988	157	16	(	(	PUNCT
admet-2988	157	17	e.g.	e.g.	ADV
admet-2988	157	18	dextrose	dextrose	NOUN
admet-2988	157	19	)	)	PUNCT
admet-2988	157	20	,	,	PUNCT
admet-2988	157	21	or	or	CCONJ
admet-2988	157	22	specific	specific	ADJ
admet-2988	157	23	toxins	toxin	NOUN
admet-2988	157	24	.	.	PUNCT
admet-2988	158	1	physical	physical	ADJ
admet-2988	158	2	disruption	disruption	NOUN
admet-2988	158	3	methods	method	NOUN
admet-2988	158	4	include	include	VERB
admet-2988	158	5	radiation	radiation	NOUN
admet-2988	158	6	,	,	PUNCT
admet-2988	158	7	microwaves	microwave	NOUN
admet-2988	158	8	,	,	PUNCT
admet-2988	158	9	thermomagnetic	thermomagnetic	ADJ
admet-2988	158	10	stimulation	stimulation	NOUN
admet-2988	158	11	,	,	PUNCT
admet-2988	158	12	and	and	CCONJ
admet-2988	158	13	ultrasound	ultrasound	NOUN
admet-2988	158	14	[	[	X
admet-2988	158	15	46,66,67,69	46,66,67,69	NUM
admet-2988	158	16	]	]	PUNCT
admet-2988	158	17	.	.	PUNCT
admet-2988	159	1	osmotic	osmotic	ADJ
admet-2988	159	2	opening	opening	NOUN
admet-2988	159	3	is	be	AUX
admet-2988	159	4	widely	widely	ADV
admet-2988	159	5	used	use	VERB
admet-2988	159	6	in	in	ADP
admet-2988	159	7	clinical	clinical	ADJ
admet-2988	159	8	practice	practice	NOUN
admet-2988	159	9	;	;	PUNCT
admet-2988	159	10	however	however	ADV
admet-2988	159	11	,	,	PUNCT
admet-2988	159	12	it	it	PRON
admet-2988	159	13	is	be	AUX
admet-2988	159	14	non	non	ADJ
admet-2988	159	15	-	-	ADJ
admet-2988	159	16	selective	selective	ADJ
admet-2988	159	17	and	and	CCONJ
admet-2988	159	18	often	often	ADV
admet-2988	159	19	associated	associate	VERB
admet-2988	159	20	with	with	ADP
admet-2988	159	21	neurotoxicity	neurotoxicity	NOUN
admet-2988	159	22	[	[	X
admet-2988	159	23	27	27	NUM
admet-2988	159	24	]	]	PUNCT
admet-2988	159	25	.	.	PUNCT
admet-2988	160	1	while	while	SCONJ
admet-2988	160	2	chemical	chemical	ADJ
admet-2988	160	3	disruption	disruption	NOUN
admet-2988	160	4	can	can	AUX
admet-2988	160	5	be	be	AUX
admet-2988	160	6	effective	effective	ADJ
admet-2988	160	7	,	,	PUNCT
admet-2988	160	8	it	it	PRON
admet-2988	160	9	carries	carry	VERB
admet-2988	160	10	significant	significant	ADJ
admet-2988	160	11	drawbacks	drawback	NOUN
admet-2988	160	12	,	,	PUNCT
admet-2988	160	13	as	as	SCONJ
admet-2988	160	14	it	it	PRON
admet-2988	160	15	may	may	AUX
admet-2988	160	16	compromise	compromise	VERB
admet-2988	160	17	the	the	DET
admet-2988	160	18	integrity	integrity	NOUN
admet-2988	160	19	and	and	CCONJ
admet-2988	160	20	function	function	NOUN
admet-2988	160	21	of	of	ADP
admet-2988	160	22	the	the	DET
admet-2988	160	23	bbb	bbb	PROPN
admet-2988	160	24	,	,	PUNCT
admet-2988	160	25	potentially	potentially	ADV
admet-2988	160	26	allowing	allow	VERB
admet-2988	160	27	harmful	harmful	ADJ
admet-2988	160	28	substances	substance	NOUN
admet-2988	160	29	to	to	PART
admet-2988	160	30	enter	enter	VERB
admet-2988	160	31	the	the	DET
admet-2988	160	32	cns	cns	NOUN
admet-2988	161	1	[	[	X
admet-2988	161	2	66	66	NUM
admet-2988	161	3	]	]	PUNCT
admet-2988	161	4	.	.	PUNCT
admet-2988	162	1	ultrasound	ultrasound	PROPN
admet-2988	162	2	offers	offer	VERB
admet-2988	162	3	an	an	DET
admet-2988	162	4	alternative	alternative	NOUN
admet-2988	162	5	and	and	CCONJ
admet-2988	162	6	promising	promising	ADJ
admet-2988	162	7	approach	approach	NOUN
admet-2988	162	8	by	by	ADP
admet-2988	162	9	momentarily	momentarily	ADV
admet-2988	162	10	suppressing	suppress	VERB
admet-2988	162	11	the	the	DET
admet-2988	162	12	expression	expression	NOUN
admet-2988	162	13	of	of	ADP
admet-2988	162	14	tight	tight	ADJ
admet-2988	162	15	junction	junction	NOUN
admet-2988	162	16	proteins	protein	NOUN
admet-2988	162	17	,	,	PUNCT
admet-2988	162	18	thereby	thereby	ADV
admet-2988	162	19	increasing	increase	VERB
admet-2988	162	20	bbb	bbb	NOUN
admet-2988	162	21	permeability	permeability	NOUN
admet-2988	162	22	without	without	ADP
admet-2988	162	23	causing	cause	VERB
admet-2988	162	24	direct	direct	ADJ
admet-2988	162	25	tissue	tissue	NOUN
admet-2988	162	26	damage	damage	NOUN
admet-2988	162	27	.	.	PUNCT
admet-2988	163	1	it	it	PRON
admet-2988	163	2	has	have	AUX
admet-2988	163	3	been	be	AUX
admet-2988	163	4	shown	show	VERB
admet-2988	163	5	to	to	PART
admet-2988	163	6	improve	improve	VERB
admet-2988	163	7	drug	drug	NOUN
admet-2988	163	8	penetration	penetration	NOUN
admet-2988	163	9	into	into	ADP
admet-2988	163	10	brain	brain	NOUN
admet-2988	163	11	tumours	tumour	NOUN
admet-2988	164	1	[	[	X
admet-2988	164	2	66	66	NUM
admet-2988	164	3	]	]	PUNCT
admet-2988	164	4	.	.	PUNCT
admet-2988	165	1	this	this	DET
admet-2988	165	2	method	method	NOUN
admet-2988	165	3	is	be	AUX
admet-2988	165	4	localized	localize	VERB
admet-2988	165	5	,	,	PUNCT
admet-2988	165	6	transient	transient	ADJ
admet-2988	165	7	,	,	PUNCT
admet-2988	165	8	and	and	CCONJ
admet-2988	165	9	reproducible	reproducible	ADJ
admet-2988	165	10	.	.	PUNCT
admet-2988	166	1	however	however	ADV
admet-2988	166	2	,	,	PUNCT
admet-2988	166	3	it	it	PRON
admet-2988	166	4	requires	require	VERB
admet-2988	166	5	specialized	specialized	ADJ
admet-2988	166	6	equipment	equipment	NOUN
admet-2988	166	7	,	,	PUNCT
admet-2988	166	8	and	and	CCONJ
admet-2988	166	9	further	further	ADJ
admet-2988	166	10	research	research	NOUN
admet-2988	166	11	is	be	AUX
admet-2988	166	12	needed	need	VERB
admet-2988	166	13	to	to	PART
admet-2988	166	14	elucidate	elucidate	VERB
admet-2988	166	15	the	the	DET
admet-2988	166	16	precise	precise	ADJ
admet-2988	166	17	mechanisms	mechanism	NOUN
admet-2988	166	18	of	of	ADP
admet-2988	166	19	bbb	bbb	PROPN
admet-2988	166	20	opening	opening	NOUN
admet-2988	166	21	and	and	CCONJ
admet-2988	166	22	to	to	PART
admet-2988	166	23	establish	establish	VERB
admet-2988	166	24	optimal	optimal	ADJ
admet-2988	166	25	monitoring	monitoring	NOUN
admet-2988	166	26	conditions	condition	NOUN
admet-2988	166	27	[	[	X
admet-2988	166	28	27	27	NUM
admet-2988	166	29	]	]	PUNCT
admet-2988	166	30	.	.	PUNCT
admet-2988	167	1	some	some	DET
admet-2988	167	2	authors	author	NOUN
admet-2988	167	3	classify	classify	VERB
admet-2988	167	4	ultrasound	ultrasound	NOUN
admet-2988	167	5	-	-	PUNCT
admet-2988	167	6	induced	induce	VERB
admet-2988	167	7	bbb	bbb	NOUN
admet-2988	167	8	opening	opening	NOUN
admet-2988	167	9	as	as	ADP
admet-2988	167	10	a	a	DET
admet-2988	167	11	non	non	ADJ
admet-2988	167	12	-	-	ADJ
admet-2988	167	13	invasive	invasive	ADJ
admet-2988	167	14	technique	technique	NOUN
admet-2988	167	15	[	[	X
admet-2988	167	16	72	72	NUM
admet-2988	167	17	]	]	X
admet-2988	167	18	,	,	PUNCT
admet-2988	167	19	primarily	primarily	ADV
admet-2988	167	20	due	due	ADP
admet-2988	167	21	to	to	ADP
admet-2988	167	22	its	its	PRON
admet-2988	167	23	reversibility	reversibility	NOUN
admet-2988	167	24	,	,	PUNCT
admet-2988	167	25	although	although	SCONJ
admet-2988	167	26	this	this	DET
admet-2988	167	27	classification	classification	NOUN
admet-2988	167	28	remains	remain	VERB
admet-2988	167	29	controversial	controversial	ADJ
admet-2988	167	30	given	give	VERB
admet-2988	167	31	its	its	PRON
admet-2988	167	32	impact	impact	NOUN
admet-2988	167	33	on	on	ADP
admet-2988	167	34	barrier	barrier	NOUN
admet-2988	167	35	integrity	integrity	NOUN
admet-2988	167	36	.	.	PUNCT
admet-2988	168	1	electroporation	electroporation	NOUN
admet-2988	168	2	is	be	AUX
admet-2988	168	3	a	a	DET
admet-2988	168	4	less	less	ADV
admet-2988	168	5	aggressive	aggressive	ADJ
admet-2988	168	6	invasive	invasive	ADJ
admet-2988	168	7	alternative	alternative	NOUN
admet-2988	168	8	for	for	ADP
admet-2988	168	9	bbb	bbb	NOUN
admet-2988	168	10	disruption	disruption	NOUN
admet-2988	168	11	.	.	PUNCT
admet-2988	169	1	this	this	DET
admet-2988	169	2	technique	technique	NOUN
admet-2988	169	3	uses	use	VERB
admet-2988	169	4	pulsed	pulse	VERB
admet-2988	169	5	electric	electric	ADJ
admet-2988	169	6	fields	field	NOUN
admet-2988	169	7	to	to	PART
admet-2988	169	8	momentarily	momentarily	ADV
admet-2988	169	9	destabilize	destabilize	VERB
admet-2988	169	10	cell	cell	NOUN
admet-2988	169	11	membranes	membrane	NOUN
admet-2988	169	12	,	,	PUNCT
admet-2988	169	13	thereby	thereby	ADV
admet-2988	169	14	increasing	increase	VERB
admet-2988	169	15	permeability	permeability	NOUN
admet-2988	169	16	in	in	ADP
admet-2988	169	17	a	a	DET
admet-2988	169	18	controlled	control	VERB
admet-2988	169	19	and	and	CCONJ
admet-2988	169	20	reversible	reversible	ADJ
admet-2988	169	21	manner	manner	NOUN
admet-2988	169	22	[	[	X
admet-2988	169	23	69,70	69,70	NOUN
admet-2988	169	24	]	]	PUNCT
admet-2988	169	25	.	.	PUNCT
admet-2988	170	1	https://www.biorender.com/	https://www.biorender.com/	PROPN
admet-2988	170	2	admet	admet	PROPN
admet-2988	170	3	&	&	CCONJ
admet-2988	170	4	dmpk	dmpk	PROPN
admet-2988	170	5	13(5	13(5	NUM
admet-2988	170	6	)	)	PUNCT
admet-2988	170	7	(	(	PUNCT
admet-2988	170	8	2025	2025	NUM
admet-2988	170	9	)	)	PUNCT
admet-2988	170	10	2988	2988	NUM
admet-2988	170	11	advancing	advance	VERB
admet-2988	170	12	through	through	ADP
admet-2988	170	13	the	the	DET
admet-2988	170	14	blood	blood	NOUN
admet-2988	170	15	-	-	PUNCT
admet-2988	170	16	brain	brain	NOUN
admet-2988	170	17	barrier	barrier	NOUN
admet-2988	170	18	doi	doi	NOUN
admet-2988	170	19	:	:	PUNCT
admet-2988	170	20	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	ADJ
admet-2988	170	21	9	9	NUM
admet-2988	170	22	intracranial	intracranial	ADJ
admet-2988	170	23	administration	administration	NOUN
admet-2988	170	24	this	this	DET
admet-2988	170	25	delivery	delivery	NOUN
admet-2988	170	26	approach	approach	NOUN
admet-2988	170	27	bypasses	bypass	VERB
admet-2988	170	28	the	the	DET
admet-2988	170	29	bbb	bbb	NOUN
admet-2988	170	30	by	by	ADP
admet-2988	170	31	introducing	introduce	VERB
admet-2988	170	32	drugs	drug	NOUN
admet-2988	170	33	directly	directly	ADV
admet-2988	170	34	into	into	ADP
admet-2988	170	35	the	the	DET
admet-2988	170	36	cns	cns	NOUN
admet-2988	170	37	via	via	ADP
admet-2988	170	38	diffusion	diffusion	NOUN
admet-2988	170	39	through	through	ADP
admet-2988	170	40	the	the	DET
admet-2988	170	41	cerebrospinal	cerebrospinal	ADJ
admet-2988	170	42	fluid	fluid	NOUN
admet-2988	170	43	.	.	PUNCT
admet-2988	171	1	intrathecal	intrathecal	ADJ
admet-2988	171	2	administration	administration	NOUN
admet-2988	171	3	involves	involve	VERB
admet-2988	171	4	the	the	DET
admet-2988	171	5	injection	injection	NOUN
admet-2988	171	6	into	into	ADP
admet-2988	171	7	the	the	DET
admet-2988	171	8	spinal	spinal	ADJ
admet-2988	171	9	canal	canal	NOUN
admet-2988	171	10	or	or	CCONJ
admet-2988	171	11	subarachnoid	subarachnoid	VERB
admet-2988	171	12	space	space	NOUN
admet-2988	171	13	[	[	X
admet-2988	171	14	69	69	NUM
admet-2988	171	15	]	]	PUNCT
admet-2988	171	16	,	,	PUNCT
admet-2988	171	17	whereas	whereas	SCONJ
admet-2988	171	18	intracranial	intracranial	ADJ
admet-2988	171	19	administration	administration	NOUN
admet-2988	171	20	refers	refer	VERB
admet-2988	171	21	to	to	ADP
admet-2988	171	22	the	the	DET
admet-2988	171	23	direct	direct	ADJ
admet-2988	171	24	delivery	delivery	NOUN
admet-2988	171	25	of	of	ADP
admet-2988	171	26	drugs	drug	NOUN
admet-2988	171	27	into	into	ADP
admet-2988	171	28	the	the	DET
admet-2988	171	29	cranial	cranial	ADJ
admet-2988	171	30	cavity	cavity	NOUN
admet-2988	171	31	,	,	PUNCT
admet-2988	171	32	including	include	VERB
admet-2988	171	33	intracerebral	intracerebral	ADJ
admet-2988	171	34	,	,	PUNCT
admet-2988	171	35	intracranial	intracranial	ADJ
admet-2988	171	36	,	,	PUNCT
admet-2988	171	37	or	or	CCONJ
admet-2988	171	38	intraventricular	intraventricular	ADJ
admet-2988	171	39	injections	injection	NOUN
admet-2988	171	40	[	[	X
admet-2988	171	41	72,73	72,73	NUM
admet-2988	171	42	]	]	PUNCT
admet-2988	171	43	.	.	PUNCT
admet-2988	172	1	the	the	DET
admet-2988	172	2	main	main	ADJ
admet-2988	172	3	advantage	advantage	NOUN
admet-2988	172	4	of	of	ADP
admet-2988	172	5	these	these	DET
admet-2988	172	6	methods	method	NOUN
admet-2988	172	7	is	be	AUX
admet-2988	172	8	that	that	SCONJ
admet-2988	172	9	the	the	DET
admet-2988	172	10	entire	entire	ADJ
admet-2988	172	11	administered	administer	VERB
admet-2988	172	12	dose	dose	NOUN
admet-2988	172	13	reaches	reach	VERB
admet-2988	172	14	the	the	DET
admet-2988	172	15	brain	brain	NOUN
admet-2988	172	16	tissue	tissue	NOUN
admet-2988	172	17	,	,	PUNCT
admet-2988	172	18	avoiding	avoid	VERB
admet-2988	172	19	high	high	ADJ
admet-2988	172	20	systemic	systemic	ADJ
admet-2988	172	21	concentrations	concentration	NOUN
admet-2988	172	22	that	that	PRON
admet-2988	172	23	could	could	AUX
admet-2988	172	24	lead	lead	VERB
admet-2988	172	25	to	to	ADP
admet-2988	172	26	adverse	adverse	ADJ
admet-2988	172	27	effects	effect	NOUN
admet-2988	172	28	[	[	X
admet-2988	172	29	45,57,66	45,57,66	NOUN
admet-2988	172	30	]	]	PUNCT
admet-2988	172	31	,	,	PUNCT
admet-2988	172	32	which	which	PRON
admet-2988	172	33	is	be	AUX
admet-2988	172	34	particularly	particularly	ADV
admet-2988	172	35	relevant	relevant	ADJ
admet-2988	172	36	for	for	ADP
admet-2988	172	37	potent	potent	ADJ
admet-2988	172	38	drugs	drug	NOUN
admet-2988	172	39	with	with	ADP
admet-2988	172	40	high	high	ADJ
admet-2988	172	41	systemic	systemic	ADJ
admet-2988	172	42	toxicity	toxicity	NOUN
admet-2988	172	43	[	[	X
admet-2988	172	44	69,72	69,72	NOUN
admet-2988	172	45	]	]	X
admet-2988	172	46	.	.	PUNCT
admet-2988	173	1	however	however	ADV
admet-2988	173	2	,	,	PUNCT
admet-2988	173	3	these	these	DET
admet-2988	173	4	techniques	technique	NOUN
admet-2988	173	5	are	be	AUX
admet-2988	173	6	highly	highly	ADV
admet-2988	173	7	invasive	invasive	ADJ
admet-2988	173	8	and	and	CCONJ
admet-2988	173	9	may	may	AUX
admet-2988	173	10	result	result	VERB
admet-2988	173	11	in	in	ADP
admet-2988	173	12	poor	poor	ADJ
admet-2988	173	13	patient	patient	ADJ
admet-2988	173	14	compliance	compliance	NOUN
admet-2988	173	15	,	,	PUNCT
admet-2988	173	16	especially	especially	ADV
admet-2988	173	17	for	for	ADP
admet-2988	173	18	treatments	treatment	NOUN
admet-2988	173	19	requiring	require	VERB
admet-2988	173	20	repeated	repeat	VERB
admet-2988	173	21	dosing	dose	VERB
admet-2988	173	22	[	[	X
admet-2988	173	23	27	27	NUM
admet-2988	173	24	]	]	PUNCT
admet-2988	173	25	.	.	PUNCT
admet-2988	174	1	convection	convection	NOUN
admet-2988	174	2	-	-	PUNCT
admet-2988	174	3	enhanced	enhance	VERB
admet-2988	174	4	delivery	delivery	NOUN
admet-2988	174	5	when	when	SCONJ
admet-2988	174	6	a	a	DET
admet-2988	174	7	drug	drug	NOUN
admet-2988	174	8	is	be	AUX
admet-2988	174	9	administered	administer	VERB
admet-2988	174	10	directly	directly	ADV
admet-2988	174	11	into	into	ADP
admet-2988	174	12	the	the	DET
admet-2988	174	13	brain	brain	NOUN
admet-2988	174	14	parenchyma	parenchyma	NOUN
admet-2988	174	15	,	,	PUNCT
admet-2988	174	16	its	its	PRON
admet-2988	174	17	distribution	distribution	NOUN
admet-2988	174	18	occurs	occur	VERB
admet-2988	174	19	primarily	primarily	ADV
admet-2988	174	20	by	by	ADP
admet-2988	174	21	passive	passive	ADJ
admet-2988	174	22	diffusion	diffusion	NOUN
admet-2988	174	23	along	along	ADP
admet-2988	174	24	a	a	DET
admet-2988	174	25	concentration	concentration	NOUN
admet-2988	174	26	gradient	gradient	NOUN
admet-2988	174	27	[	[	X
admet-2988	174	28	72	72	NUM
admet-2988	174	29	]	]	PUNCT
admet-2988	174	30	.	.	PUNCT
admet-2988	175	1	however	however	ADV
admet-2988	175	2	,	,	PUNCT
admet-2988	175	3	this	this	DET
admet-2988	175	4	process	process	NOUN
admet-2988	175	5	is	be	AUX
admet-2988	175	6	limited	limit	VERB
admet-2988	175	7	by	by	ADP
admet-2988	175	8	the	the	DET
admet-2988	175	9	relatively	relatively	ADV
admet-2988	175	10	low	low	ADJ
admet-2988	175	11	extracellular	extracellular	ADJ
admet-2988	175	12	fluid	fluid	NOUN
admet-2988	175	13	volume	volume	NOUN
admet-2988	175	14	and	and	CCONJ
admet-2988	175	15	slow	slow	ADJ
admet-2988	175	16	diffusion	diffusion	NOUN
admet-2988	175	17	rates	rate	NOUN
admet-2988	175	18	within	within	ADP
admet-2988	175	19	brain	brain	NOUN
admet-2988	175	20	tissue	tissue	NOUN
admet-2988	175	21	[	[	X
admet-2988	175	22	60	60	NUM
admet-2988	175	23	]	]	PUNCT
admet-2988	175	24	.	.	PUNCT
admet-2988	176	1	convection	convection	NOUN
admet-2988	176	2	-	-	PUNCT
admet-2988	176	3	enhanced	enhance	VERB
admet-2988	176	4	delivery	delivery	NOUN
admet-2988	176	5	(	(	PUNCT
admet-2988	176	6	ced	ced	PROPN
admet-2988	176	7	)	)	PUNCT
admet-2988	176	8	overcomes	overcome	VERB
admet-2988	176	9	these	these	DET
admet-2988	176	10	limitations	limitation	NOUN
admet-2988	176	11	by	by	ADP
admet-2988	176	12	applying	apply	VERB
admet-2988	176	13	positive	positive	ADJ
admet-2988	176	14	pressure	pressure	NOUN
admet-2988	176	15	during	during	ADP
admet-2988	176	16	administration	administration	NOUN
admet-2988	176	17	to	to	PART
admet-2988	176	18	facilitate	facilitate	VERB
admet-2988	176	19	drug	drug	NOUN
admet-2988	176	20	dispersion	dispersion	NOUN
admet-2988	176	21	[	[	X
admet-2988	176	22	73	73	NUM
admet-2988	176	23	]	]	PUNCT
admet-2988	176	24	.	.	PUNCT
admet-2988	177	1	in	in	ADP
admet-2988	177	2	ced	ced	PROPN
admet-2988	177	3	,	,	PUNCT
admet-2988	177	4	a	a	DET
admet-2988	177	5	catheter	catheter	NOUN
admet-2988	177	6	is	be	AUX
admet-2988	177	7	inserted	insert	VERB
admet-2988	177	8	into	into	ADP
admet-2988	177	9	a	a	DET
admet-2988	177	10	brain	brain	NOUN
admet-2988	177	11	tumour	tumour	NOUN
admet-2988	177	12	,	,	PUNCT
admet-2988	177	13	and	and	CCONJ
admet-2988	177	14	a	a	DET
admet-2988	177	15	continuous	continuous	ADJ
admet-2988	177	16	infusion	infusion	NOUN
admet-2988	177	17	system	system	NOUN
admet-2988	177	18	maintains	maintain	VERB
admet-2988	177	19	a	a	DET
admet-2988	177	20	positive	positive	ADJ
admet-2988	177	21	pressure	pressure	NOUN
admet-2988	177	22	gradient	gradient	NOUN
admet-2988	177	23	to	to	PART
admet-2988	177	24	enhance	enhance	VERB
admet-2988	177	25	drug	drug	NOUN
admet-2988	177	26	penetration	penetration	NOUN
admet-2988	178	1	[	[	X
admet-2988	178	2	65,67	65,67	NUM
admet-2988	178	3	]	]	PUNCT
admet-2988	178	4	.	.	PUNCT
admet-2988	179	1	despite	despite	SCONJ
admet-2988	179	2	its	its	PRON
admet-2988	179	3	potential	potential	ADJ
admet-2988	179	4	benefits	benefit	NOUN
admet-2988	179	5	,	,	PUNCT
admet-2988	179	6	ced	ce	VERB
admet-2988	179	7	presents	present	VERB
admet-2988	179	8	challenges	challenge	NOUN
admet-2988	179	9	such	such	ADJ
admet-2988	179	10	as	as	ADP
admet-2988	179	11	unpredictable	unpredictable	ADJ
admet-2988	179	12	drug	drug	NOUN
admet-2988	179	13	distribution	distribution	NOUN
admet-2988	179	14	,	,	PUNCT
admet-2988	179	15	difficulty	difficulty	NOUN
admet-2988	179	16	in	in	ADP
admet-2988	179	17	real	real	ADJ
admet-2988	179	18	-	-	PUNCT
admet-2988	179	19	time	time	NOUN
admet-2988	179	20	monitoring	monitoring	NOUN
admet-2988	179	21	,	,	PUNCT
admet-2988	179	22	and	and	CCONJ
admet-2988	179	23	the	the	DET
admet-2988	179	24	need	need	NOUN
admet-2988	179	25	for	for	ADP
admet-2988	179	26	personalized	personalized	ADJ
admet-2988	179	27	optimization	optimization	NOUN
admet-2988	179	28	of	of	ADP
admet-2988	179	29	catheter	catheter	NOUN
admet-2988	179	30	design	design	NOUN
admet-2988	179	31	and	and	CCONJ
admet-2988	179	32	placement	placement	NOUN
admet-2988	179	33	[	[	X
admet-2988	179	34	27	27	NUM
admet-2988	179	35	]	]	PUNCT
admet-2988	179	36	.	.	PUNCT
admet-2988	180	1	implantable	implantable	ADJ
admet-2988	180	2	drug	drug	NOUN
admet-2988	180	3	delivery	delivery	NOUN
admet-2988	180	4	devices	device	VERB
admet-2988	180	5	another	another	DET
admet-2988	180	6	invasive	invasive	ADJ
admet-2988	180	7	technique	technique	NOUN
admet-2988	180	8	involves	involve	VERB
admet-2988	180	9	the	the	DET
admet-2988	180	10	surgical	surgical	ADJ
admet-2988	180	11	implantation	implantation	NOUN
admet-2988	180	12	of	of	ADP
admet-2988	180	13	biodegradable	biodegradable	ADJ
admet-2988	180	14	polymer	polymer	NOUN
admet-2988	180	15	-	-	PUNCT
admet-2988	180	16	based	base	VERB
admet-2988	180	17	drug	drug	NOUN
admet-2988	180	18	delivery	delivery	NOUN
admet-2988	180	19	systems	system	NOUN
admet-2988	180	20	into	into	ADP
admet-2988	180	21	the	the	DET
admet-2988	180	22	cns	cns	NOUN
admet-2988	181	1	[	[	X
admet-2988	181	2	67	67	NUM
admet-2988	181	3	]	]	PUNCT
admet-2988	181	4	.	.	PUNCT
admet-2988	182	1	these	these	DET
admet-2988	182	2	devices	device	NOUN
admet-2988	182	3	allow	allow	VERB
admet-2988	182	4	sustained	sustained	ADJ
admet-2988	182	5	drug	drug	NOUN
admet-2988	182	6	release	release	NOUN
admet-2988	182	7	[	[	X
admet-2988	182	8	27	27	NUM
admet-2988	182	9	]	]	PUNCT
admet-2988	182	10	and	and	CCONJ
admet-2988	182	11	show	show	VERB
admet-2988	182	12	promise	promise	NOUN
admet-2988	182	13	for	for	ADP
admet-2988	182	14	the	the	DET
admet-2988	182	15	treatment	treatment	NOUN
admet-2988	182	16	of	of	ADP
admet-2988	182	17	neurodegenerative	neurodegenerative	ADJ
admet-2988	182	18	diseases	disease	NOUN
admet-2988	182	19	and	and	CCONJ
admet-2988	182	20	brain	brain	NOUN
admet-2988	182	21	injury	injury	NOUN
admet-2988	182	22	[	[	X
admet-2988	182	23	21	21	NUM
admet-2988	182	24	]	]	PUNCT
admet-2988	182	25	.	.	PUNCT
admet-2988	183	1	implant	implant	ADJ
admet-2988	183	2	types	type	NOUN
admet-2988	183	3	include	include	VERB
admet-2988	183	4	gels	gel	NOUN
admet-2988	183	5	,	,	PUNCT
admet-2988	183	6	microspheres	microsphere	NOUN
admet-2988	183	7	,	,	PUNCT
admet-2988	183	8	nanospheres	nanosphere	NOUN
admet-2988	183	9	,	,	PUNCT
admet-2988	183	10	and	and	CCONJ
admet-2988	183	11	wafers	wafer	NOUN
admet-2988	183	12	[	[	X
admet-2988	183	13	65	65	NUM
admet-2988	183	14	]	]	PUNCT
admet-2988	183	15	.	.	PUNCT
admet-2988	184	1	nonetheless	nonetheless	ADV
admet-2988	184	2	,	,	PUNCT
admet-2988	184	3	these	these	DET
admet-2988	184	4	systems	system	NOUN
admet-2988	184	5	have	have	VERB
admet-2988	184	6	notable	notable	ADJ
admet-2988	184	7	limitations	limitation	NOUN
admet-2988	184	8	,	,	PUNCT
admet-2988	184	9	including	include	VERB
admet-2988	184	10	restricted	restrict	VERB
admet-2988	184	11	drug	drug	NOUN
admet-2988	184	12	distribution	distribution	NOUN
admet-2988	184	13	,	,	PUNCT
admet-2988	184	14	dose	dose	VERB
admet-2988	184	15	constraints	constraint	NOUN
admet-2988	184	16	due	due	ADP
admet-2988	184	17	to	to	ADP
admet-2988	184	18	implant	implant	ADJ
admet-2988	184	19	size	size	NOUN
admet-2988	184	20	,	,	PUNCT
admet-2988	184	21	and	and	CCONJ
admet-2988	184	22	unresolved	unresolved	ADJ
admet-2988	184	23	concerns	concern	NOUN
admet-2988	184	24	regarding	regard	VERB
admet-2988	184	25	long	long	ADJ
admet-2988	184	26	-	-	PUNCT
admet-2988	184	27	term	term	NOUN
admet-2988	184	28	safety	safety	NOUN
admet-2988	184	29	[	[	X
admet-2988	184	30	27	27	NUM
admet-2988	184	31	]	]	PUNCT
admet-2988	184	32	.	.	PUNCT
admet-2988	185	1	non	non	ADJ
admet-2988	185	2	-	-	ADJ
admet-2988	185	3	invasive	invasive	ADJ
admet-2988	185	4	methods	method	NOUN
admet-2988	185	5	non	non	ADJ
admet-2988	185	6	-	-	ADJ
admet-2988	185	7	invasive	invasive	ADJ
admet-2988	185	8	approaches	approach	NOUN
admet-2988	185	9	primarily	primarily	ADV
admet-2988	185	10	rely	rely	VERB
admet-2988	185	11	on	on	ADP
admet-2988	185	12	pharmaceutical	pharmaceutical	ADJ
admet-2988	185	13	strategies	strategy	NOUN
admet-2988	185	14	that	that	PRON
admet-2988	185	15	enable	enable	VERB
admet-2988	185	16	drug	drug	NOUN
admet-2988	185	17	delivery	delivery	NOUN
admet-2988	185	18	to	to	ADP
admet-2988	185	19	the	the	DET
admet-2988	185	20	cns	cns	NOUN
admet-2988	185	21	while	while	SCONJ
admet-2988	185	22	avoiding	avoid	VERB
admet-2988	185	23	the	the	DET
admet-2988	185	24	risks	risk	NOUN
admet-2988	185	25	and	and	CCONJ
admet-2988	185	26	invasiveness	invasiveness	NOUN
admet-2988	185	27	of	of	ADP
admet-2988	185	28	surgical	surgical	ADJ
admet-2988	185	29	interventions	intervention	NOUN
admet-2988	185	30	[	[	X
admet-2988	185	31	66	66	NUM
admet-2988	185	32	]	]	PUNCT
admet-2988	185	33	.	.	PUNCT
admet-2988	186	1	traditional	traditional	ADJ
admet-2988	186	2	non	non	ADJ
admet-2988	186	3	-	-	ADJ
admet-2988	186	4	invasive	invasive	ADJ
admet-2988	186	5	methods	method	NOUN
admet-2988	186	6	include	include	VERB
admet-2988	186	7	intranasal	intranasal	ADJ
admet-2988	186	8	administration	administration	NOUN
admet-2988	186	9	,	,	PUNCT
admet-2988	186	10	the	the	DET
admet-2988	186	11	exploitation	exploitation	NOUN
admet-2988	186	12	of	of	ADP
admet-2988	186	13	endogenous	endogenous	ADJ
admet-2988	186	14	transport	transport	NOUN
admet-2988	186	15	mechanisms	mechanism	NOUN
admet-2988	186	16	,	,	PUNCT
admet-2988	186	17	such	such	ADJ
admet-2988	186	18	as	as	ADP
admet-2988	186	19	viral	viral	ADJ
admet-2988	186	20	vectors	vector	NOUN
admet-2988	186	21	,	,	PUNCT
admet-2988	186	22	extracellular	extracellular	ADJ
admet-2988	186	23	vesicles	vesicle	NOUN
admet-2988	186	24	,	,	PUNCT
admet-2988	186	25	and	and	CCONJ
admet-2988	186	26	immune	immune	ADJ
admet-2988	186	27	cells	cell	NOUN
admet-2988	186	28	,	,	PUNCT
admet-2988	186	29	and	and	CCONJ
admet-2988	186	30	drug	drug	NOUN
admet-2988	186	31	modification	modification	NOUN
admet-2988	186	32	using	use	VERB
admet-2988	186	33	transport	transport	NOUN
admet-2988	186	34	vectors	vector	NOUN
admet-2988	186	35	and	and	CCONJ
admet-2988	186	36	nanotechnology	nanotechnology	NOUN
admet-2988	186	37	-	-	PUNCT
admet-2988	186	38	based	base	VERB
admet-2988	186	39	delivery	delivery	NOUN
admet-2988	186	40	systems	system	NOUN
admet-2988	186	41	[	[	X
admet-2988	186	42	69,70	69,70	NOUN
admet-2988	186	43	]	]	PUNCT
admet-2988	186	44	.	.	PUNCT
admet-2988	187	1	additionally	additionally	ADV
admet-2988	187	2	,	,	PUNCT
admet-2988	187	3	the	the	DET
admet-2988	187	4	synthesis	synthesis	NOUN
admet-2988	187	5	or	or	CCONJ
admet-2988	187	6	structural	structural	ADJ
admet-2988	187	7	modification	modification	NOUN
admet-2988	187	8	of	of	ADP
admet-2988	187	9	drugs	drug	NOUN
admet-2988	187	10	,	,	PUNCT
admet-2988	187	11	including	include	VERB
admet-2988	187	12	prodrug	prodrug	NOUN
admet-2988	187	13	strategies	strategy	NOUN
admet-2988	187	14	outlined	outline	VERB
admet-2988	187	15	at	at	ADP
admet-2988	187	16	the	the	DET
admet-2988	187	17	beginning	beginning	NOUN
admet-2988	187	18	of	of	ADP
admet-2988	187	19	section	section	NOUN
admet-2988	187	20	optimizing	optimize	VERB
admet-2988	187	21	therapeutic	therapeutic	ADJ
admet-2988	187	22	access	access	NOUN
admet-2988	187	23	to	to	ADP
admet-2988	187	24	the	the	DET
admet-2988	187	25	brain	brain	NOUN
admet-2988	187	26	:	:	PUNCT
admet-2988	187	27	strategies	strategy	NOUN
admet-2988	187	28	to	to	PART
admet-2988	187	29	overcome	overcome	VERB
admet-2988	187	30	the	the	DET
admet-2988	187	31	blood	blood	NOUN
admet-2988	187	32	-	-	PUNCT
admet-2988	187	33	brain	brain	NOUN
admet-2988	187	34	barrier	barrier	NOUN
admet-2988	187	35	,	,	PUNCT
admet-2988	187	36	also	also	ADV
admet-2988	187	37	falls	fall	VERB
admet-2988	187	38	within	within	ADP
admet-2988	187	39	this	this	DET
admet-2988	187	40	category	category	NOUN
admet-2988	187	41	[	[	X
admet-2988	187	42	27,65	27,65	NUM
admet-2988	187	43	]	]	PUNCT
admet-2988	187	44	.	.	PUNCT
admet-2988	188	1	intranasal	intranasal	PROPN
admet-2988	188	2	administration	administration	PROPN
admet-2988	188	3	the	the	DET
admet-2988	188	4	nasal	nasal	PROPN
admet-2988	188	5	route	route	PROPN
admet-2988	188	6	is	be	AUX
admet-2988	188	7	a	a	DET
admet-2988	188	8	drug	drug	NOUN
admet-2988	188	9	delivery	delivery	NOUN
admet-2988	188	10	pathway	pathway	NOUN
admet-2988	188	11	that	that	PRON
admet-2988	188	12	can	can	AUX
admet-2988	188	13	be	be	AUX
admet-2988	188	14	used	use	VERB
admet-2988	188	15	for	for	ADP
admet-2988	188	16	both	both	PRON
admet-2988	188	17	systemic	systemic	ADJ
admet-2988	188	18	administration	administration	NOUN
admet-2988	188	19	and	and	CCONJ
admet-2988	188	20	direct	direct	ADJ
admet-2988	188	21	brain	brain	NOUN
admet-2988	188	22	access	access	NOUN
admet-2988	188	23	[	[	X
admet-2988	188	24	69	69	NUM
admet-2988	188	25	]	]	PUNCT
admet-2988	188	26	.	.	PUNCT
admet-2988	189	1	through	through	ADP
admet-2988	189	2	this	this	DET
admet-2988	189	3	route	route	NOUN
admet-2988	189	4	,	,	PUNCT
admet-2988	189	5	small	small	ADJ
admet-2988	189	6	lipophilic	lipophilic	ADJ
admet-2988	189	7	molecules	molecule	NOUN
admet-2988	189	8	and	and	CCONJ
admet-2988	189	9	biological	biological	ADJ
admet-2988	189	10	agents	agent	NOUN
admet-2988	189	11	can	can	AUX
admet-2988	189	12	penetrate	penetrate	VERB
admet-2988	189	13	the	the	DET
admet-2988	189	14	nasal	nasal	ADJ
admet-2988	189	15	epithelium	epithelium	NOUN
admet-2988	189	16	and	and	CCONJ
admet-2988	189	17	reach	reach	VERB
admet-2988	189	18	the	the	DET
admet-2988	189	19	cns	cns	NOUN
admet-2988	189	20	.	.	PUNCT
admet-2988	190	1	alternatively	alternatively	ADV
admet-2988	190	2	,	,	PUNCT
admet-2988	190	3	drugs	drug	NOUN
admet-2988	190	4	can	can	AUX
admet-2988	190	5	reach	reach	VERB
admet-2988	190	6	the	the	DET
admet-2988	190	7	brain	brain	NOUN
admet-2988	190	8	via	via	ADP
admet-2988	190	9	transneuronal	transneuronal	ADJ
admet-2988	190	10	transport	transport	NOUN
admet-2988	190	11	along	along	ADP
admet-2988	190	12	the	the	DET
admet-2988	190	13	trigeminal	trigeminal	ADJ
admet-2988	190	14	and	and	CCONJ
admet-2988	190	15	olfactory	olfactory	ADJ
admet-2988	190	16	nerves	nerve	NOUN
admet-2988	191	1	[	[	X
admet-2988	191	2	60,66	60,66	NOUN
admet-2988	191	3	]	]	X
admet-2988	191	4	.	.	PUNCT
admet-2988	192	1	in	in	ADP
admet-2988	192	2	recent	recent	ADJ
admet-2988	192	3	years	year	NOUN
admet-2988	192	4	,	,	PUNCT
admet-2988	192	5	intranasal	intranasal	ADJ
admet-2988	192	6	delivery	delivery	NOUN
admet-2988	192	7	has	have	AUX
admet-2988	192	8	been	be	AUX
admet-2988	192	9	the	the	DET
admet-2988	192	10	subject	subject	NOUN
admet-2988	192	11	of	of	ADP
admet-2988	192	12	extensive	extensive	ADJ
admet-2988	192	13	research	research	NOUN
admet-2988	192	14	,	,	PUNCT
admet-2988	192	15	demonstrating	demonstrate	VERB
admet-2988	192	16	efficacy	efficacy	NOUN
admet-2988	192	17	in	in	ADP
admet-2988	192	18	preclinical	preclinical	ADJ
admet-2988	192	19	models	model	NOUN
admet-2988	192	20	for	for	ADP
admet-2988	192	21	various	various	ADJ
admet-2988	192	22	therapeutic	therapeutic	ADJ
admet-2988	192	23	applications	application	NOUN
admet-2988	192	24	.	.	PUNCT
admet-2988	193	1	current	current	ADJ
admet-2988	193	2	efforts	effort	NOUN
admet-2988	193	3	are	be	AUX
admet-2988	193	4	focused	focus	VERB
admet-2988	193	5	on	on	ADP
admet-2988	193	6	achieving	achieve	VERB
admet-2988	193	7	clinical	clinical	ADJ
admet-2988	193	8	translation	translation	NOUN
admet-2988	193	9	,	,	PUNCT
admet-2988	193	10	positioning	position	VERB
admet-2988	193	11	this	this	DET
admet-2988	193	12	strategy	strategy	NOUN
admet-2988	193	13	as	as	ADP
admet-2988	193	14	a	a	DET
admet-2988	193	15	promising	promising	ADJ
admet-2988	193	16	alternative	alternative	NOUN
admet-2988	193	17	for	for	ADP
admet-2988	193	18	the	the	DET
admet-2988	193	19	treatment	treatment	NOUN
admet-2988	193	20	of	of	ADP
admet-2988	193	21	cns	cns	NOUN
admet-2988	193	22	disorders	disorder	NOUN
admet-2988	193	23	[	[	X
admet-2988	193	24	74	74	NUM
admet-2988	193	25	-	-	SYM
admet-2988	193	26	76	76	NUM
admet-2988	193	27	]	]	PUNCT
admet-2988	193	28	.	.	PUNCT
admet-2988	194	1	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	194	2	r.	r.	PROPN
admet-2988	194	3	vargas	vargas	PROPN
admet-2988	194	4	et	et	PROPN
admet-2988	194	5	al	al	PROPN
admet-2988	194	6	.	.	PROPN
admet-2988	194	7	admet	admet	PROPN
admet-2988	194	8	&	&	CCONJ
admet-2988	194	9	dmpk	dmpk	PROPN
admet-2988	194	10	13(5	13(5	NUM
admet-2988	194	11	)	)	PUNCT
admet-2988	194	12	(	(	PUNCT
admet-2988	194	13	2025	2025	NUM
admet-2988	194	14	)	)	PUNCT
admet-2988	194	15	2988	2988	NUM
admet-2988	194	16	10	10	NUM
admet-2988	194	17	this	this	DET
admet-2988	194	18	method	method	NOUN
admet-2988	194	19	is	be	AUX
admet-2988	194	20	fast	fast	ADJ
admet-2988	194	21	and	and	CCONJ
admet-2988	194	22	offers	offer	VERB
admet-2988	194	23	high	high	ADJ
admet-2988	194	24	bioavailability	bioavailability	NOUN
admet-2988	194	25	once	once	SCONJ
admet-2988	194	26	the	the	DET
admet-2988	194	27	drug	drug	NOUN
admet-2988	194	28	is	be	AUX
admet-2988	194	29	absorbed	absorb	VERB
admet-2988	194	30	.	.	PUNCT
admet-2988	195	1	however	however	ADV
admet-2988	195	2	,	,	PUNCT
admet-2988	195	3	bypassing	bypass	VERB
admet-2988	195	4	the	the	DET
admet-2988	195	5	nasal	nasal	ADJ
admet-2988	195	6	epithelium	epithelium	NOUN
admet-2988	195	7	and	and	CCONJ
admet-2988	195	8	mucus	mucus	NOUN
admet-2988	195	9	layer	layer	NOUN
admet-2988	195	10	,	,	PUNCT
admet-2988	195	11	as	as	ADV
admet-2988	195	12	well	well	ADV
admet-2988	195	13	as	as	ADP
admet-2988	195	14	avoiding	avoid	VERB
admet-2988	195	15	enzymatic	enzymatic	ADJ
admet-2988	195	16	degradation	degradation	NOUN
admet-2988	195	17	by	by	ADP
admet-2988	195	18	the	the	DET
admet-2988	195	19	nasal	nasal	PROPN
admet-2988	195	20	mucosa	mucosa	PROPN
admet-2988	195	21	,	,	PUNCT
admet-2988	195	22	remains	remain	VERB
admet-2988	195	23	a	a	DET
admet-2988	195	24	challenge	challenge	NOUN
admet-2988	195	25	,	,	PUNCT
admet-2988	195	26	making	make	VERB
admet-2988	195	27	this	this	DET
admet-2988	195	28	route	route	NOUN
admet-2988	195	29	particularly	particularly	ADV
admet-2988	195	30	suitable	suitable	ADJ
admet-2988	195	31	for	for	ADP
admet-2988	195	32	highly	highly	ADV
admet-2988	195	33	potent	potent	ADJ
admet-2988	195	34	drugs	drug	NOUN
admet-2988	195	35	[	[	X
admet-2988	195	36	27	27	NUM
admet-2988	195	37	]	]	PUNCT
admet-2988	195	38	.	.	PUNCT
admet-2988	196	1	the	the	DET
admet-2988	196	2	use	use	NOUN
admet-2988	196	3	of	of	ADP
admet-2988	196	4	nanoparticles	nanoparticle	NOUN
admet-2988	196	5	(	(	PUNCT
admet-2988	196	6	section	section	NOUN
admet-2988	196	7	efflux	efflux	NOUN
admet-2988	196	8	pump	pump	NOUN
admet-2988	196	9	inhibition	inhibition	NOUN
admet-2988	196	10	below	below	ADV
admet-2988	196	11	)	)	PUNCT
admet-2988	196	12	in	in	ADP
admet-2988	196	13	this	this	DET
admet-2988	196	14	context	context	NOUN
admet-2988	196	15	enhances	enhance	VERB
admet-2988	196	16	drug	drug	NOUN
admet-2988	196	17	interaction	interaction	NOUN
admet-2988	196	18	with	with	ADP
admet-2988	196	19	the	the	DET
admet-2988	196	20	nasal	nasal	ADJ
admet-2988	196	21	epithelium	epithelium	NOUN
admet-2988	196	22	and	and	CCONJ
admet-2988	196	23	mucus	mucus	NOUN
admet-2988	196	24	and	and	CCONJ
admet-2988	196	25	prevents	prevent	VERB
admet-2988	196	26	the	the	DET
admet-2988	196	27	enzymatic	enzymatic	ADJ
admet-2988	196	28	degradation	degradation	NOUN
admet-2988	196	29	.	.	PUNCT
admet-2988	197	1	some	some	DET
admet-2988	197	2	examples	example	NOUN
admet-2988	197	3	of	of	ADP
admet-2988	197	4	nose	nose	NOUN
admet-2988	197	5	-	-	PUNCT
admet-2988	197	6	to	to	ADP
admet-2988	197	7	-	-	PUNCT
admet-2988	197	8	brain	brain	NOUN
admet-2988	197	9	delivery	delivery	NOUN
admet-2988	197	10	include	include	VERB
admet-2988	197	11	the	the	DET
admet-2988	197	12	study	study	NOUN
admet-2988	197	13	by	by	ADP
admet-2988	197	14	koo	koo	PROPN
admet-2988	197	15	et	et	PROPN
admet-2988	197	16	al	al	PROPN
admet-2988	197	17	.	.	PUNCT
admet-2988	198	1	[	[	X
admet-2988	198	2	77	77	NUM
admet-2988	198	3	]	]	X
admet-2988	198	4	,	,	PUNCT
admet-2988	198	5	which	which	PRON
admet-2988	198	6	used	use	VERB
admet-2988	198	7	polymeric	polymeric	ADJ
admet-2988	198	8	micelles	micelle	NOUN
admet-2988	198	9	functionalized	functionalize	VERB
admet-2988	198	10	with	with	ADP
admet-2988	198	11	a	a	DET
admet-2988	198	12	cell	cell	NOUN
admet-2988	198	13	-	-	PUNCT
admet-2988	198	14	penetrating	penetrate	VERB
admet-2988	198	15	peptide	peptide	NOUN
admet-2988	198	16	to	to	PART
admet-2988	198	17	target	target	VERB
admet-2988	198	18	glioblastoma	glioblastoma	NOUN
admet-2988	198	19	,	,	PUNCT
admet-2988	198	20	demonstrating	demonstrate	VERB
admet-2988	198	21	in	in	ADP
admet-2988	198	22	vivo	vivo	ADJ
admet-2988	198	23	efficacy	efficacy	NOUN
admet-2988	198	24	.	.	PUNCT
admet-2988	199	1	sharma	sharma	PROPN
admet-2988	199	2	et	et	PROPN
admet-2988	199	3	al	al	PROPN
admet-2988	199	4	.	.	PUNCT
admet-2988	200	1	[	[	X
admet-2988	200	2	78	78	NUM
admet-2988	200	3	]	]	PUNCT
admet-2988	200	4	reported	report	VERB
admet-2988	200	5	enhanced	enhanced	ADJ
admet-2988	200	6	brain	brain	NOUN
admet-2988	200	7	concentrations	concentration	NOUN
admet-2988	200	8	of	of	ADP
admet-2988	200	9	paroxetine	paroxetine	NOUN
admet-2988	200	10	using	use	VERB
admet-2988	200	11	chitosan	chitosan	NOUN
admet-2988	200	12	-	-	PUNCT
admet-2988	200	13	modified	modify	VERB
admet-2988	200	14	polymeric	polymeric	ADJ
admet-2988	200	15	nanoparticles	nanoparticle	NOUN
admet-2988	200	16	,	,	PUNCT
admet-2988	200	17	while	while	SCONJ
admet-2988	200	18	deshmukh	deshmukh	PROPN
admet-2988	200	19	et	et	PROPN
admet-2988	200	20	al	al	PROPN
admet-2988	200	21	.	.	PUNCT
admet-2988	201	1	[	[	X
admet-2988	201	2	79	79	NUM
admet-2988	201	3	]	]	PUNCT
admet-2988	201	4	achieved	achieve	VERB
admet-2988	201	5	successful	successful	ADJ
admet-2988	201	6	delivery	delivery	NOUN
admet-2988	201	7	of	of	ADP
admet-2988	201	8	paroxetine	paroxetine	NOUN
admet-2988	201	9	using	use	VERB
admet-2988	201	10	ligand	ligand	NOUN
admet-2988	201	11	-	-	PUNCT
admet-2988	201	12	conjugated	conjugate	VERB
admet-2988	201	13	polymeric	polymeric	ADJ
admet-2988	201	14	nanoparticles	nanoparticle	NOUN
admet-2988	201	15	.	.	PUNCT
admet-2988	202	1	viral	viral	ADJ
admet-2988	202	2	vector	vector	NOUN
admet-2988	202	3	-	-	PUNCT
admet-2988	202	4	mediated	mediate	VERB
admet-2988	202	5	drug	drug	NOUN
admet-2988	202	6	delivery	delivery	NOUN
admet-2988	202	7	neurotropic	neurotropic	NOUN
admet-2988	202	8	viruses	virus	NOUN
admet-2988	202	9	can	can	AUX
admet-2988	202	10	be	be	AUX
admet-2988	202	11	used	use	VERB
admet-2988	202	12	as	as	ADP
admet-2988	202	13	effective	effective	ADJ
admet-2988	202	14	drug	drug	NOUN
admet-2988	202	15	delivery	delivery	NOUN
admet-2988	202	16	vehicles	vehicle	NOUN
admet-2988	202	17	to	to	ADP
admet-2988	202	18	the	the	DET
admet-2988	202	19	brain	brain	NOUN
admet-2988	203	1	[	[	X
admet-2988	203	2	65	65	NUM
admet-2988	203	3	]	]	PUNCT
admet-2988	203	4	.	.	PUNCT
admet-2988	204	1	this	this	PRON
admet-2988	204	2	can	can	AUX
admet-2988	204	3	be	be	AUX
admet-2988	204	4	achieved	achieve	VERB
admet-2988	204	5	either	either	CCONJ
admet-2988	204	6	by	by	ADP
admet-2988	204	7	using	use	VERB
admet-2988	204	8	viral	viral	ADJ
admet-2988	204	9	vectors	vector	NOUN
admet-2988	204	10	that	that	PRON
admet-2988	204	11	inherently	inherently	ADV
admet-2988	204	12	cross	cross	VERB
admet-2988	204	13	the	the	DET
admet-2988	204	14	bbb	bbb	NOUN
admet-2988	204	15	or	or	CCONJ
admet-2988	204	16	by	by	ADP
admet-2988	204	17	modifying	modify	VERB
admet-2988	204	18	their	their	PRON
admet-2988	204	19	surface	surface	NOUN
admet-2988	204	20	to	to	PART
admet-2988	204	21	incorporate	incorporate	VERB
admet-2988	204	22	natural	natural	ADJ
admet-2988	204	23	ligands	ligand	NOUN
admet-2988	204	24	that	that	PRON
admet-2988	204	25	interact	interact	VERB
admet-2988	204	26	with	with	ADP
admet-2988	204	27	endogenous	endogenous	ADJ
admet-2988	204	28	receptor	receptor	NOUN
admet-2988	204	29	-	-	PUNCT
admet-2988	204	30	mediated	mediate	VERB
admet-2988	204	31	transcytosis	transcytosis	NOUN
admet-2988	204	32	systems	system	NOUN
admet-2988	205	1	[	[	X
admet-2988	205	2	80,81	80,81	NUM
admet-2988	205	3	]	]	PUNCT
admet-2988	205	4	.	.	PUNCT
admet-2988	206	1	viral	viral	ADJ
admet-2988	206	2	vectors	vector	NOUN
admet-2988	206	3	can	can	AUX
admet-2988	206	4	also	also	ADV
admet-2988	206	5	be	be	AUX
admet-2988	206	6	combined	combine	VERB
admet-2988	206	7	with	with	ADP
admet-2988	206	8	hyperosmotic	hyperosmotic	ADJ
admet-2988	206	9	agents	agent	NOUN
admet-2988	206	10	to	to	PART
admet-2988	206	11	enhance	enhance	VERB
admet-2988	206	12	transcellular	transcellular	NOUN
admet-2988	206	13	transport	transport	NOUN
admet-2988	206	14	[	[	X
admet-2988	206	15	66	66	NUM
admet-2988	206	16	]	]	PUNCT
admet-2988	206	17	.	.	PUNCT
admet-2988	207	1	common	common	ADJ
admet-2988	207	2	examples	example	NOUN
admet-2988	207	3	of	of	ADP
admet-2988	207	4	viral	viral	ADJ
admet-2988	207	5	vectors	vector	NOUN
admet-2988	207	6	include	include	VERB
admet-2988	207	7	adenoviruses	adenovirus	NOUN
admet-2988	207	8	,	,	PUNCT
admet-2988	207	9	herpesviruses	herpesviruse	NOUN
admet-2988	207	10	,	,	PUNCT
admet-2988	207	11	recombinant	recombinant	ADJ
admet-2988	207	12	sv-40	sv-40	ADJ
admet-2988	207	13	viruses	virus	NOUN
admet-2988	207	14	,	,	PUNCT
admet-2988	207	15	and	and	CCONJ
admet-2988	207	16	lentiviruses	lentiviruse	NOUN
admet-2988	207	17	,	,	PUNCT
admet-2988	207	18	among	among	ADP
admet-2988	207	19	others	other	NOUN
admet-2988	207	20	[	[	X
admet-2988	207	21	27,66	27,66	X
admet-2988	207	22	]	]	PUNCT
admet-2988	207	23	.	.	PUNCT
admet-2988	208	1	these	these	DET
admet-2988	208	2	vectors	vector	NOUN
admet-2988	208	3	offer	offer	VERB
admet-2988	208	4	high	high	ADJ
admet-2988	208	5	efficiency	efficiency	NOUN
admet-2988	208	6	,	,	PUNCT
admet-2988	208	7	specific	specific	ADJ
admet-2988	208	8	cellular	cellular	ADJ
admet-2988	208	9	tropism	tropism	NOUN
admet-2988	208	10	,	,	PUNCT
admet-2988	208	11	and	and	CCONJ
admet-2988	208	12	relative	relative	ADJ
admet-2988	208	13	scalability	scalability	NOUN
admet-2988	208	14	.	.	PUNCT
admet-2988	209	1	however	however	ADV
admet-2988	209	2	,	,	PUNCT
admet-2988	209	3	they	they	PRON
admet-2988	209	4	also	also	ADV
admet-2988	209	5	carry	carry	VERB
admet-2988	209	6	risks	risk	NOUN
admet-2988	209	7	,	,	PUNCT
admet-2988	209	8	including	include	VERB
admet-2988	209	9	potential	potential	ADJ
admet-2988	209	10	immune	immune	ADJ
admet-2988	209	11	responses	response	NOUN
admet-2988	209	12	,	,	PUNCT
admet-2988	209	13	oncogenesis	oncogenesis	NOUN
admet-2988	209	14	,	,	PUNCT
admet-2988	209	15	and	and	CCONJ
admet-2988	209	16	mortality	mortality	NOUN
admet-2988	210	1	[	[	X
admet-2988	210	2	27	27	NUM
admet-2988	210	3	]	]	PUNCT
admet-2988	210	4	.	.	PUNCT
admet-2988	211	1	cell	cell	NOUN
admet-2988	211	2	-	-	PUNCT
admet-2988	211	3	mediated	mediate	VERB
admet-2988	211	4	drug	drug	NOUN
admet-2988	211	5	delivery	delivery	NOUN
admet-2988	211	6	cell	cell	NOUN
admet-2988	211	7	-	-	PUNCT
admet-2988	211	8	mediated	mediate	VERB
admet-2988	211	9	drug	drug	NOUN
admet-2988	211	10	delivery	delivery	NOUN
admet-2988	211	11	,	,	PUNCT
admet-2988	211	12	also	also	ADV
admet-2988	211	13	known	know	VERB
admet-2988	211	14	as	as	ADP
admet-2988	211	15	the	the	DET
admet-2988	211	16	“	"	PUNCT
admet-2988	211	17	trojan	trojan	NOUN
admet-2988	211	18	horse	horse	NOUN
admet-2988	211	19	”	"	PUNCT
admet-2988	211	20	strategy	strategy	NOUN
admet-2988	211	21	(	(	PUNCT
admet-2988	211	22	see	see	VERB
admet-2988	211	23	section	section	NOUN
admet-2988	211	24	cell	cell	NOUN
admet-2988	211	25	-	-	PUNCT
admet-2988	211	26	mediated	mediate	VERB
admet-2988	211	27	transcytosis	transcytosis	NOUN
admet-2988	211	28	)	)	PUNCT
admet-2988	211	29	,	,	PUNCT
admet-2988	211	30	utilizes	utilize	VERB
admet-2988	211	31	immune	immune	ADJ
admet-2988	211	32	cells	cell	NOUN
admet-2988	211	33	such	such	ADJ
admet-2988	211	34	as	as	ADP
admet-2988	211	35	macrophages	macrophage	NOUN
admet-2988	211	36	,	,	PUNCT
admet-2988	211	37	monocytes	monocyte	NOUN
admet-2988	211	38	,	,	PUNCT
admet-2988	211	39	and	and	CCONJ
admet-2988	211	40	neutrophils	neutrophil	NOUN
admet-2988	211	41	to	to	PART
admet-2988	211	42	transport	transport	VERB
admet-2988	211	43	therapeutic	therapeutic	ADJ
admet-2988	211	44	agents	agent	NOUN
admet-2988	211	45	across	across	ADP
admet-2988	211	46	the	the	DET
admet-2988	211	47	bbb	bbb	NOUN
admet-2988	212	1	[	[	X
admet-2988	212	2	46,65,82	46,65,82	NUM
admet-2988	212	3	]	]	PUNCT
admet-2988	212	4	.	.	PUNCT
admet-2988	213	1	the	the	DET
admet-2988	213	2	phagocytic	phagocytic	ADJ
admet-2988	213	3	properties	property	NOUN
admet-2988	213	4	of	of	ADP
admet-2988	213	5	these	these	DET
admet-2988	213	6	cells	cell	NOUN
admet-2988	213	7	facilitate	facilitate	VERB
admet-2988	213	8	the	the	DET
admet-2988	213	9	internalization	internalization	NOUN
admet-2988	213	10	of	of	ADP
admet-2988	213	11	therapeutic	therapeutic	ADJ
admet-2988	213	12	agents	agent	NOUN
admet-2988	213	13	and	and	CCONJ
admet-2988	213	14	their	their	PRON
admet-2988	213	15	subsequent	subsequent	ADJ
admet-2988	213	16	transport	transport	NOUN
admet-2988	213	17	into	into	ADP
admet-2988	213	18	the	the	DET
admet-2988	213	19	brain	brain	NOUN
admet-2988	213	20	during	during	ADP
admet-2988	213	21	the	the	DET
admet-2988	213	22	migration	migration	NOUN
admet-2988	213	23	of	of	ADP
admet-2988	213	24	immune	immune	ADJ
admet-2988	213	25	cells	cell	NOUN
admet-2988	213	26	in	in	ADP
admet-2988	213	27	response	response	NOUN
admet-2988	213	28	to	to	ADP
admet-2988	213	29	inflammatory	inflammatory	ADJ
admet-2988	213	30	processes	process	NOUN
admet-2988	213	31	[	[	X
admet-2988	213	32	69	69	NUM
admet-2988	213	33	]	]	PUNCT
admet-2988	213	34	.	.	PUNCT
admet-2988	214	1	a	a	DET
admet-2988	214	2	practical	practical	ADJ
admet-2988	214	3	advantage	advantage	NOUN
admet-2988	214	4	of	of	ADP
admet-2988	214	5	this	this	DET
admet-2988	214	6	approach	approach	NOUN
admet-2988	214	7	is	be	AUX
admet-2988	214	8	that	that	SCONJ
admet-2988	214	9	it	it	PRON
admet-2988	214	10	does	do	AUX
admet-2988	214	11	not	not	PART
admet-2988	214	12	require	require	VERB
admet-2988	214	13	drugs	drug	NOUN
admet-2988	214	14	to	to	PART
admet-2988	214	15	be	be	AUX
admet-2988	214	16	nanometric	nanometric	ADJ
admet-2988	214	17	in	in	ADP
admet-2988	214	18	size	size	NOUN
admet-2988	214	19	,	,	PUNCT
admet-2988	214	20	as	as	SCONJ
admet-2988	214	21	is	be	AUX
admet-2988	214	22	often	often	ADV
admet-2988	214	23	required	require	VERB
admet-2988	214	24	for	for	ADP
admet-2988	214	25	other	other	ADJ
admet-2988	214	26	strategies	strategy	NOUN
admet-2988	214	27	[	[	X
admet-2988	214	28	46	46	NUM
admet-2988	214	29	]	]	PUNCT
admet-2988	214	30	.	.	PUNCT
admet-2988	215	1	however	however	ADV
admet-2988	215	2	,	,	PUNCT
admet-2988	215	3	limitations	limitation	NOUN
admet-2988	215	4	include	include	VERB
admet-2988	215	5	potential	potential	ADJ
admet-2988	215	6	issues	issue	NOUN
admet-2988	215	7	with	with	ADP
admet-2988	215	8	cellular	cellular	ADJ
admet-2988	215	9	viability	viability	NOUN
admet-2988	215	10	due	due	ADP
admet-2988	215	11	to	to	ADP
admet-2988	215	12	the	the	DET
admet-2988	215	13	transported	transport	VERB
admet-2988	215	14	compound	compound	NOUN
admet-2988	215	15	and	and	CCONJ
admet-2988	215	16	the	the	DET
admet-2988	215	17	risk	risk	NOUN
admet-2988	215	18	of	of	ADP
admet-2988	215	19	immune	immune	ADJ
admet-2988	215	20	activation	activation	NOUN
admet-2988	215	21	,	,	PUNCT
admet-2988	215	22	which	which	PRON
admet-2988	215	23	may	may	AUX
admet-2988	215	24	lead	lead	VERB
admet-2988	215	25	to	to	ADP
admet-2988	215	26	adverse	adverse	ADJ
admet-2988	215	27	effects	effect	NOUN
admet-2988	215	28	such	such	ADJ
admet-2988	215	29	as	as	ADP
admet-2988	215	30	an	an	DET
admet-2988	215	31	increased	increased	ADJ
admet-2988	215	32	risk	risk	NOUN
admet-2988	215	33	of	of	ADP
admet-2988	215	34	thrombosis	thrombosis	NOUN
admet-2988	215	35	[	[	X
admet-2988	215	36	65	65	NUM
admet-2988	215	37	]	]	PUNCT
admet-2988	215	38	.	.	PUNCT
admet-2988	216	1	exosome	exosome	PROPN
admet-2988	216	2	-	-	PUNCT
admet-2988	216	3	based	base	VERB
admet-2988	216	4	drug	drug	NOUN
admet-2988	216	5	delivery	delivery	NOUN
admet-2988	216	6	extracellular	extracellular	ADJ
admet-2988	216	7	vesicles	vesicle	NOUN
admet-2988	216	8	,	,	PUNCT
admet-2988	216	9	particularly	particularly	ADV
admet-2988	216	10	exosomes	exosome	NOUN
admet-2988	216	11	,	,	PUNCT
admet-2988	216	12	are	be	AUX
admet-2988	216	13	endogenously	endogenously	ADV
admet-2988	216	14	derived	derive	VERB
admet-2988	216	15	particles	particle	NOUN
admet-2988	216	16	ranging	range	VERB
admet-2988	216	17	in	in	ADP
admet-2988	216	18	diameter	diameter	NOUN
admet-2988	216	19	from	from	ADP
admet-2988	216	20	30	30	NUM
admet-2988	216	21	to	to	PART
admet-2988	216	22	150	150	NUM
admet-2988	216	23	nm	nm	NOUN
admet-2988	216	24	,	,	PUNCT
admet-2988	216	25	with	with	ADP
admet-2988	216	26	the	the	DET
admet-2988	216	27	ability	ability	NOUN
admet-2988	216	28	to	to	PART
admet-2988	216	29	cross	cross	VERB
admet-2988	216	30	biological	biological	ADJ
admet-2988	216	31	barriers	barrier	NOUN
admet-2988	216	32	[	[	X
admet-2988	216	33	27,66	27,66	X
admet-2988	216	34	]	]	PUNCT
admet-2988	216	35	.	.	PUNCT
admet-2988	217	1	these	these	DET
admet-2988	217	2	small	small	ADJ
admet-2988	217	3	membrane	membrane	NOUN
admet-2988	217	4	-	-	PUNCT
admet-2988	217	5	derived	derive	VERB
admet-2988	217	6	vesicles	vesicle	NOUN
admet-2988	217	7	can	can	AUX
admet-2988	217	8	encapsulate	encapsulate	VERB
admet-2988	217	9	and	and	CCONJ
admet-2988	217	10	transport	transport	NOUN
admet-2988	217	11	lipids	lipid	NOUN
admet-2988	217	12	,	,	PUNCT
admet-2988	217	13	nucleic	nucleic	ADJ
admet-2988	217	14	acids	acid	NOUN
admet-2988	217	15	,	,	PUNCT
admet-2988	217	16	and	and	CCONJ
admet-2988	217	17	proteins	protein	NOUN
admet-2988	217	18	.	.	PUNCT
admet-2988	218	1	theoretically	theoretically	ADV
admet-2988	218	2	,	,	PUNCT
admet-2988	218	3	they	they	PRON
admet-2988	218	4	are	be	AUX
admet-2988	218	5	produced	produce	VERB
admet-2988	218	6	by	by	ADP
admet-2988	218	7	all	all	DET
admet-2988	218	8	cell	cell	NOUN
admet-2988	218	9	types	type	NOUN
admet-2988	218	10	[	[	X
admet-2988	218	11	83	83	NUM
admet-2988	218	12	]	]	PUNCT
admet-2988	218	13	and	and	CCONJ
admet-2988	218	14	can	can	AUX
admet-2988	218	15	be	be	AUX
admet-2988	218	16	used	use	VERB
admet-2988	218	17	for	for	ADP
admet-2988	218	18	drug	drug	NOUN
admet-2988	218	19	delivery	delivery	NOUN
admet-2988	218	20	in	in	ADP
admet-2988	218	21	either	either	CCONJ
admet-2988	218	22	their	their	PRON
admet-2988	218	23	natural	natural	ADJ
admet-2988	218	24	or	or	CCONJ
admet-2988	218	25	modified	modified	ADJ
admet-2988	218	26	forms	form	NOUN
admet-2988	218	27	[	[	X
admet-2988	218	28	84	84	NUM
admet-2988	218	29	]	]	PUNCT
admet-2988	218	30	.	.	PUNCT
admet-2988	219	1	exosomes	exosome	NOUN
admet-2988	219	2	have	have	AUX
admet-2988	219	3	demonstrated	demonstrate	VERB
admet-2988	219	4	the	the	DET
admet-2988	219	5	ability	ability	NOUN
admet-2988	219	6	to	to	PART
admet-2988	219	7	cross	cross	VERB
admet-2988	219	8	the	the	DET
admet-2988	219	9	bbb	bbb	NOUN
admet-2988	219	10	and	and	CCONJ
admet-2988	219	11	play	play	VERB
admet-2988	219	12	a	a	DET
admet-2988	219	13	role	role	NOUN
admet-2988	219	14	in	in	ADP
admet-2988	219	15	peripheral	peripheral	ADJ
admet-2988	219	16	-	-	PUNCT
admet-2988	219	17	to	to	ADP
admet-2988	219	18	-	-	PUNCT
admet-2988	219	19	brain	brain	NOUN
admet-2988	219	20	communication	communication	NOUN
admet-2988	219	21	,	,	PUNCT
admet-2988	219	22	contributing	contribute	VERB
admet-2988	219	23	to	to	ADP
admet-2988	219	24	normal	normal	ADJ
admet-2988	219	25	neuronal	neuronal	ADJ
admet-2988	219	26	function	function	NOUN
admet-2988	219	27	[	[	X
admet-2988	219	28	85	85	NUM
admet-2988	219	29	]	]	PUNCT
admet-2988	219	30	.	.	PUNCT
admet-2988	220	1	they	they	PRON
admet-2988	220	2	are	be	AUX
admet-2988	220	3	highly	highly	ADV
admet-2988	220	4	biocompatible	biocompatible	ADJ
admet-2988	220	5	and	and	CCONJ
admet-2988	220	6	provide	provide	VERB
admet-2988	220	7	protection	protection	NOUN
admet-2988	220	8	and	and	CCONJ
admet-2988	220	9	stability	stability	NOUN
admet-2988	220	10	for	for	ADP
admet-2988	220	11	the	the	DET
admet-2988	220	12	encapsulated	encapsulate	VERB
admet-2988	220	13	therapeutic	therapeutic	ADJ
admet-2988	220	14	agents	agent	NOUN
admet-2988	220	15	[	[	X
admet-2988	220	16	27	27	NUM
admet-2988	220	17	]	]	PUNCT
admet-2988	220	18	.	.	PUNCT
admet-2988	221	1	some	some	DET
admet-2988	221	2	illustrative	illustrative	ADJ
admet-2988	221	3	applications	application	NOUN
admet-2988	221	4	of	of	ADP
admet-2988	221	5	exosome	exosome	NOUN
admet-2988	221	6	-	-	PUNCT
admet-2988	221	7	based	base	VERB
admet-2988	221	8	delivery	delivery	NOUN
admet-2988	221	9	systems	system	NOUN
admet-2988	221	10	include	include	VERB
admet-2988	221	11	brain	brain	NOUN
admet-2988	221	12	-	-	PUNCT
admet-2988	221	13	targeted	target	VERB
admet-2988	221	14	exosomes	exosome	NOUN
admet-2988	221	15	that	that	PRON
admet-2988	221	16	are	be	AUX
admet-2988	221	17	surface	surface	NOUN
admet-2988	221	18	-	-	PUNCT
admet-2988	221	19	modified	modify	VERB
admet-2988	221	20	with	with	ADP
admet-2988	221	21	peptides	peptide	NOUN
admet-2988	221	22	for	for	ADP
admet-2988	221	23	targeting	target	VERB
admet-2988	221	24	.	.	PUNCT
admet-2988	222	1	for	for	ADP
admet-2988	222	2	example	example	NOUN
admet-2988	222	3	,	,	PUNCT
admet-2988	222	4	exosomes	exosome	NOUN
admet-2988	222	5	loaded	load	VERB
admet-2988	222	6	with	with	ADP
admet-2988	222	7	mir-133b	mir-133b	NOUN
admet-2988	222	8	have	have	AUX
admet-2988	222	9	demonstrated	demonstrate	VERB
admet-2988	222	10	neuroprotective	neuroprotective	ADJ
admet-2988	222	11	effects	effect	NOUN
admet-2988	222	12	in	in	ADP
admet-2988	222	13	a	a	DET
admet-2988	222	14	parkinson	parkinson	NOUN
admet-2988	222	15	’s	’s	PART
admet-2988	222	16	disease	disease	NOUN
admet-2988	222	17	model	model	NOUN
admet-2988	222	18	by	by	ADP
admet-2988	222	19	improving	improve	VERB
admet-2988	222	20	motor	motor	NOUN
admet-2988	222	21	function	function	NOUN
admet-2988	222	22	,	,	PUNCT
admet-2988	222	23	reducing	reduce	VERB
admet-2988	222	24	tau	tau	PROPN
admet-2988	222	25	phosphorylation	phosphorylation	NOUN
admet-2988	222	26	,	,	PUNCT
admet-2988	222	27	and	and	CCONJ
admet-2988	222	28	attenuating	attenuate	VERB
admet-2988	222	29	neuronal	neuronal	ADJ
admet-2988	222	30	damage	damage	NOUN
admet-2988	222	31	[	[	X
admet-2988	222	32	86	86	NUM
admet-2988	222	33	]	]	PUNCT
admet-2988	222	34	.	.	PUNCT
admet-2988	223	1	in	in	ADP
admet-2988	223	2	traumatic	traumatic	ADJ
admet-2988	223	3	brain	brain	NOUN
admet-2988	223	4	injury	injury	NOUN
admet-2988	223	5	models	model	NOUN
admet-2988	223	6	,	,	PUNCT
admet-2988	223	7	exosomes	exosome	NOUN
admet-2988	223	8	encapsulating	encapsulate	VERB
admet-2988	223	9	neuroprotective	neuroprotective	ADJ
admet-2988	223	10	peptides	peptide	NOUN
admet-2988	223	11	have	have	AUX
admet-2988	223	12	demonstrated	demonstrate	VERB
admet-2988	223	13	cytoprotective	cytoprotective	ADJ
admet-2988	223	14	effects	effect	NOUN
admet-2988	223	15	in	in	ADP
admet-2988	223	16	vitro	vitro	X
admet-2988	223	17	and	and	CCONJ
admet-2988	223	18	improved	improve	VERB
admet-2988	223	19	behavioural	behavioural	ADJ
admet-2988	223	20	and	and	CCONJ
admet-2988	223	21	histological	histological	ADJ
admet-2988	223	22	outcomes	outcome	NOUN
admet-2988	223	23	in	in	ADP
admet-2988	223	24	vivo	vivo	NOUN
admet-2988	223	25	following	follow	VERB
admet-2988	223	26	intravenous	intravenous	ADJ
admet-2988	223	27	administration	administration	NOUN
admet-2988	223	28	[	[	X
admet-2988	223	29	87	87	NUM
admet-2988	223	30	]	]	PUNCT
admet-2988	223	31	.	.	PUNCT
admet-2988	224	1	moreover	moreover	ADV
admet-2988	224	2	,	,	PUNCT
admet-2988	224	3	admet	admet	PROPN
admet-2988	224	4	&	&	CCONJ
admet-2988	224	5	dmpk	dmpk	PROPN
admet-2988	224	6	13(5	13(5	NUM
admet-2988	224	7	)	)	PUNCT
admet-2988	224	8	(	(	PUNCT
admet-2988	224	9	2025	2025	NUM
admet-2988	224	10	)	)	PUNCT
admet-2988	224	11	2988	2988	NUM
admet-2988	224	12	advancing	advance	VERB
admet-2988	224	13	through	through	ADP
admet-2988	224	14	the	the	DET
admet-2988	224	15	blood	blood	NOUN
admet-2988	224	16	-	-	PUNCT
admet-2988	224	17	brain	brain	NOUN
admet-2988	224	18	barrier	barrier	NOUN
admet-2988	224	19	doi	doi	NOUN
admet-2988	224	20	:	:	PUNCT
admet-2988	224	21	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	224	22	11	11	NUM
admet-2988	224	23	exosome	exosome	ADV
admet-2988	224	24	-	-	PUNCT
admet-2988	224	25	based	base	VERB
admet-2988	224	26	strategies	strategy	NOUN
admet-2988	224	27	have	have	AUX
admet-2988	224	28	been	be	AUX
admet-2988	224	29	used	use	VERB
admet-2988	224	30	to	to	PART
admet-2988	224	31	enhance	enhance	VERB
admet-2988	224	32	the	the	DET
admet-2988	224	33	delivery	delivery	NOUN
admet-2988	224	34	of	of	ADP
admet-2988	224	35	temozolomide	temozolomide	NOUN
admet-2988	224	36	for	for	ADP
admet-2988	224	37	glioblastoma	glioblastoma	NOUN
admet-2988	224	38	treatment	treatment	NOUN
admet-2988	224	39	,	,	PUNCT
admet-2988	224	40	resulting	result	VERB
admet-2988	224	41	in	in	ADP
admet-2988	224	42	increased	increase	VERB
admet-2988	224	43	apoptosis	apoptosis	NOUN
admet-2988	224	44	and	and	CCONJ
admet-2988	224	45	improved	improve	VERB
admet-2988	224	46	therapeutic	therapeutic	ADJ
admet-2988	224	47	efficacy	efficacy	NOUN
admet-2988	225	1	[	[	X
admet-2988	225	2	88	88	NUM
admet-2988	225	3	]	]	PUNCT
admet-2988	225	4	.	.	PUNCT
admet-2988	226	1	however	however	ADV
admet-2988	226	2	,	,	PUNCT
admet-2988	226	3	and	and	CCONJ
admet-2988	226	4	despite	despite	SCONJ
admet-2988	226	5	their	their	PRON
admet-2988	226	6	promising	promising	ADJ
admet-2988	226	7	results	result	NOUN
admet-2988	226	8	,	,	PUNCT
admet-2988	226	9	several	several	ADJ
admet-2988	226	10	challenges	challenge	NOUN
admet-2988	226	11	remain	remain	VERB
admet-2988	226	12	,	,	PUNCT
admet-2988	226	13	particularly	particularly	ADV
admet-2988	226	14	in	in	ADP
admet-2988	226	15	the	the	DET
admet-2988	226	16	standardization	standardization	NOUN
admet-2988	226	17	of	of	ADP
admet-2988	226	18	isolation	isolation	NOUN
admet-2988	226	19	and	and	CCONJ
admet-2988	226	20	purification	purification	NOUN
admet-2988	226	21	protocols	protocol	NOUN
admet-2988	226	22	[	[	X
admet-2988	226	23	27	27	NUM
admet-2988	226	24	]	]	PUNCT
admet-2988	226	25	.	.	PUNCT
admet-2988	227	1	in	in	ADP
admet-2988	227	2	addition	addition	NOUN
admet-2988	227	3	,	,	PUNCT
admet-2988	227	4	a	a	DET
admet-2988	227	5	significant	significant	ADJ
admet-2988	227	6	proportion	proportion	NOUN
admet-2988	227	7	of	of	ADP
admet-2988	227	8	systemically	systemically	ADV
admet-2988	227	9	administered	administer	VERB
admet-2988	227	10	exosomes	exosome	NOUN
admet-2988	227	11	is	be	AUX
admet-2988	227	12	sequestered	sequester	VERB
admet-2988	227	13	by	by	ADP
admet-2988	227	14	the	the	DET
admet-2988	227	15	liver	liver	NOUN
admet-2988	227	16	,	,	PUNCT
admet-2988	227	17	lung	lung	NOUN
admet-2988	227	18	,	,	PUNCT
admet-2988	227	19	spleen	spleen	NOUN
admet-2988	227	20	,	,	PUNCT
admet-2988	227	21	and	and	CCONJ
admet-2988	227	22	phagocytic	phagocytic	ADJ
admet-2988	227	23	cells	cell	NOUN
admet-2988	227	24	of	of	ADP
admet-2988	227	25	the	the	DET
admet-2988	227	26	immune	immune	ADJ
admet-2988	227	27	system	system	NOUN
admet-2988	227	28	.	.	PUNCT
admet-2988	228	1	this	this	DET
admet-2988	228	2	issue	issue	NOUN
admet-2988	228	3	can	can	AUX
admet-2988	228	4	be	be	AUX
admet-2988	228	5	mitigated	mitigate	VERB
admet-2988	228	6	by	by	ADP
admet-2988	228	7	surface	surface	NOUN
admet-2988	228	8	modification	modification	NOUN
admet-2988	228	9	with	with	ADP
admet-2988	228	10	peptides	peptide	NOUN
admet-2988	228	11	or	or	CCONJ
admet-2988	228	12	proteins	protein	NOUN
admet-2988	228	13	to	to	PART
admet-2988	228	14	enhance	enhance	VERB
admet-2988	228	15	brain	brain	NOUN
admet-2988	228	16	targeting	target	VERB
admet-2988	228	17	[	[	X
admet-2988	228	18	27,66	27,66	NOUN
admet-2988	228	19	]	]	PUNCT
admet-2988	228	20	.	.	PUNCT
admet-2988	229	1	shuttle	shuttle	NOUN
admet-2988	229	2	peptides	peptide	NOUN
admet-2988	229	3	and	and	CCONJ
admet-2988	229	4	protein	protein	NOUN
admet-2988	229	5	vectors	vector	NOUN
admet-2988	229	6	peptides	peptide	NOUN
admet-2988	229	7	can	can	AUX
admet-2988	229	8	facilitate	facilitate	VERB
admet-2988	229	9	cns	cns	NOUN
admet-2988	229	10	drug	drug	NOUN
admet-2988	229	11	delivery	delivery	NOUN
admet-2988	229	12	by	by	ADP
admet-2988	229	13	exploiting	exploit	VERB
admet-2988	229	14	the	the	DET
admet-2988	229	15	bbb	bbb	PROPN
admet-2988	229	16	intrinsic	intrinsic	ADJ
admet-2988	229	17	transport	transport	NOUN
admet-2988	229	18	mechanisms	mechanism	NOUN
admet-2988	229	19	[	[	X
admet-2988	229	20	89	89	NUM
admet-2988	229	21	]	]	PUNCT
admet-2988	229	22	.	.	PUNCT
admet-2988	230	1	this	this	DET
admet-2988	230	2	strategy	strategy	NOUN
admet-2988	230	3	involves	involve	VERB
admet-2988	230	4	modifying	modify	VERB
admet-2988	230	5	drugs	drug	NOUN
admet-2988	230	6	with	with	ADP
admet-2988	230	7	cationic	cationic	ADJ
admet-2988	230	8	proteins	protein	NOUN
admet-2988	230	9	or	or	CCONJ
admet-2988	230	10	peptides	peptide	NOUN
admet-2988	230	11	to	to	PART
admet-2988	230	12	facilitate	facilitate	VERB
admet-2988	230	13	their	their	PRON
admet-2988	230	14	transport	transport	NOUN
admet-2988	230	15	across	across	ADP
admet-2988	230	16	the	the	DET
admet-2988	230	17	bbb	bbb	NOUN
admet-2988	230	18	via	via	ADP
admet-2988	230	19	endogenous	endogenous	ADJ
admet-2988	230	20	transport	transport	NOUN
admet-2988	230	21	mechanisms	mechanism	NOUN
admet-2988	230	22	[	[	X
admet-2988	230	23	46,89	46,89	NOUN
admet-2988	230	24	]	]	PUNCT
admet-2988	230	25	.	.	PUNCT
admet-2988	231	1	these	these	DET
admet-2988	231	2	vectors	vector	NOUN
admet-2988	231	3	,	,	PUNCT
admet-2988	231	4	known	know	VERB
admet-2988	231	5	as	as	ADP
admet-2988	231	6	shuttle	shuttle	NOUN
admet-2988	231	7	proteins	protein	NOUN
admet-2988	231	8	or	or	CCONJ
admet-2988	231	9	shuttle	shuttle	NOUN
admet-2988	231	10	peptides	peptide	NOUN
admet-2988	231	11	,	,	PUNCT
admet-2988	231	12	can	can	AUX
admet-2988	231	13	be	be	AUX
admet-2988	231	14	used	use	VERB
admet-2988	231	15	for	for	ADP
admet-2988	231	16	small	small	ADJ
admet-2988	231	17	molecule	molecule	NOUN
admet-2988	231	18	drugs	drug	NOUN
admet-2988	231	19	[	[	X
admet-2988	231	20	90	90	NUM
admet-2988	231	21	]	]	PUNCT
admet-2988	231	22	,	,	PUNCT
admet-2988	231	23	biologics	biologic	NOUN
admet-2988	231	24	[	[	X
admet-2988	231	25	91,92	91,92	NOUN
admet-2988	231	26	]	]	X
admet-2988	231	27	,	,	PUNCT
admet-2988	231	28	or	or	CCONJ
admet-2988	231	29	combined	combine	VERB
admet-2988	231	30	with	with	ADP
admet-2988	231	31	other	other	ADJ
admet-2988	231	32	delivery	delivery	NOUN
admet-2988	231	33	strategies	strategy	NOUN
admet-2988	231	34	such	such	ADJ
admet-2988	231	35	as	as	ADP
admet-2988	231	36	nanoparticles	nanoparticle	NOUN
admet-2988	231	37	[	[	X
admet-2988	231	38	93	93	NUM
admet-2988	231	39	-	-	SYM
admet-2988	231	40	95	95	NUM
admet-2988	231	41	]	]	PUNCT
admet-2988	231	42	,	,	PUNCT
admet-2988	231	43	as	as	SCONJ
admet-2988	231	44	explained	explain	VERB
admet-2988	231	45	in	in	ADP
admet-2988	231	46	the	the	DET
admet-2988	231	47	section	section	NOUN
admet-2988	231	48	nanotechnology	nanotechnology	NOUN
admet-2988	231	49	-	-	PUNCT
admet-2988	231	50	based	base	VERB
admet-2988	231	51	strategies	strategy	NOUN
admet-2988	231	52	for	for	ADP
admet-2988	231	53	drug	drug	NOUN
admet-2988	231	54	delivery	delivery	NOUN
admet-2988	231	55	across	across	ADP
admet-2988	231	56	the	the	DET
admet-2988	231	57	bbb	bbb	PROPN
admet-2988	231	58	.	.	PUNCT
admet-2988	232	1	shuttle	shuttle	NOUN
admet-2988	232	2	peptides	peptide	NOUN
admet-2988	232	3	allows	allow	VERB
admet-2988	232	4	both	both	CCONJ
admet-2988	232	5	passive	passive	ADJ
admet-2988	232	6	and	and	CCONJ
admet-2988	232	7	active	active	ADJ
admet-2988	232	8	transport	transport	NOUN
admet-2988	232	9	across	across	ADP
admet-2988	232	10	the	the	DET
admet-2988	232	11	bbb	bbb	NOUN
admet-2988	232	12	,	,	PUNCT
admet-2988	232	13	enhancing	enhance	VERB
admet-2988	232	14	versatility	versatility	NOUN
admet-2988	232	15	and	and	CCONJ
admet-2988	232	16	efficiency	efficiency	NOUN
admet-2988	232	17	in	in	ADP
admet-2988	232	18	drug	drug	NOUN
admet-2988	232	19	delivery	delivery	NOUN
admet-2988	232	20	[	[	X
admet-2988	232	21	89,90	89,90	X
admet-2988	232	22	]	]	PUNCT
admet-2988	232	23	.	.	PUNCT
admet-2988	233	1	efflux	efflux	VERB
admet-2988	233	2	pump	pump	NOUN
admet-2988	233	3	inhibition	inhibition	NOUN
admet-2988	233	4	given	give	VERB
admet-2988	233	5	their	their	PRON
admet-2988	233	6	role	role	NOUN
admet-2988	233	7	in	in	ADP
admet-2988	233	8	limiting	limit	VERB
admet-2988	233	9	drug	drug	NOUN
admet-2988	233	10	accumulation	accumulation	NOUN
admet-2988	233	11	within	within	ADP
admet-2988	233	12	the	the	DET
admet-2988	233	13	cns	cns	NOUN
admet-2988	233	14	,	,	PUNCT
admet-2988	233	15	efflux	efflux	NOUN
admet-2988	233	16	pumps	pump	NOUN
admet-2988	233	17	have	have	AUX
admet-2988	233	18	become	become	VERB
admet-2988	233	19	a	a	DET
admet-2988	233	20	target	target	NOUN
admet-2988	233	21	for	for	ADP
admet-2988	233	22	strategies	strategy	NOUN
admet-2988	233	23	aimed	aim	VERB
admet-2988	233	24	at	at	ADP
admet-2988	233	25	improving	improve	VERB
admet-2988	233	26	therapeutic	therapeutic	ADJ
admet-2988	233	27	retention	retention	NOUN
admet-2988	233	28	in	in	ADP
admet-2988	233	29	the	the	DET
admet-2988	233	30	brain	brain	NOUN
admet-2988	233	31	.	.	PUNCT
admet-2988	234	1	selective	selective	ADJ
admet-2988	234	2	inhibition	inhibition	NOUN
admet-2988	234	3	of	of	ADP
admet-2988	234	4	these	these	DET
admet-2988	234	5	transporters	transporter	NOUN
admet-2988	234	6	has	have	AUX
admet-2988	234	7	been	be	AUX
admet-2988	234	8	explored	explore	VERB
admet-2988	234	9	to	to	PART
admet-2988	234	10	improve	improve	VERB
admet-2988	234	11	drug	drug	NOUN
admet-2988	234	12	efficacy	efficacy	NOUN
admet-2988	234	13	,	,	PUNCT
admet-2988	234	14	particularly	particularly	ADV
admet-2988	234	15	for	for	ADP
admet-2988	234	16	lipophilic	lipophilic	ADJ
admet-2988	234	17	compounds	compound	NOUN
admet-2988	234	18	that	that	PRON
admet-2988	234	19	are	be	AUX
admet-2988	234	20	otherwise	otherwise	ADV
admet-2988	234	21	rapidly	rapidly	ADV
admet-2988	234	22	cleared	clear	VERB
admet-2988	234	23	before	before	ADP
admet-2988	234	24	reaching	reach	VERB
admet-2988	234	25	therapeutic	therapeutic	ADJ
admet-2988	234	26	concentrations	concentration	NOUN
admet-2988	235	1	[	[	X
admet-2988	235	2	65,67,69	65,67,69	NUM
admet-2988	235	3	]	]	PUNCT
admet-2988	235	4	.	.	PUNCT
admet-2988	236	1	nanotechnology	nanotechnology	NOUN
admet-2988	236	2	-	-	PUNCT
admet-2988	236	3	based	base	VERB
admet-2988	236	4	strategies	strategy	NOUN
admet-2988	236	5	for	for	ADP
admet-2988	236	6	drug	drug	NOUN
admet-2988	236	7	delivery	delivery	NOUN
admet-2988	236	8	across	across	ADP
admet-2988	236	9	the	the	DET
admet-2988	236	10	bbb	bbb	PROPN
admet-2988	236	11	nanostructures	nanostructure	NOUN
admet-2988	236	12	have	have	VERB
admet-2988	236	13	unique	unique	ADJ
admet-2988	236	14	properties	property	NOUN
admet-2988	236	15	that	that	PRON
admet-2988	236	16	enhance	enhance	VERB
admet-2988	236	17	their	their	PRON
admet-2988	236	18	potential	potential	NOUN
admet-2988	236	19	for	for	ADP
admet-2988	236	20	crossing	cross	VERB
admet-2988	236	21	physiological	physiological	ADJ
admet-2988	236	22	barriers	barrier	NOUN
admet-2988	236	23	and	and	CCONJ
admet-2988	236	24	support	support	NOUN
admet-2988	236	25	applications	application	NOUN
admet-2988	236	26	in	in	ADP
admet-2988	236	27	drug	drug	NOUN
admet-2988	236	28	delivery	delivery	NOUN
admet-2988	236	29	,	,	PUNCT
admet-2988	236	30	brain	brain	NOUN
admet-2988	236	31	imaging	imaging	NOUN
admet-2988	236	32	and	and	CCONJ
admet-2988	236	33	diagnostics	diagnostic	NOUN
admet-2988	236	34	.	.	PUNCT
admet-2988	237	1	these	these	DET
admet-2988	237	2	properties	property	NOUN
admet-2988	237	3	include	include	VERB
admet-2988	237	4	their	their	PRON
admet-2988	237	5	small	small	ADJ
admet-2988	237	6	size	size	NOUN
admet-2988	237	7	,	,	PUNCT
admet-2988	237	8	surface	surface	NOUN
admet-2988	237	9	modification	modification	NOUN
admet-2988	237	10	capabilities	capability	NOUN
admet-2988	237	11	,	,	PUNCT
admet-2988	237	12	material	material	NOUN
admet-2988	237	13	versatility	versatility	NOUN
admet-2988	237	14	for	for	ADP
admet-2988	237	15	fabrication	fabrication	NOUN
admet-2988	237	16	,	,	PUNCT
admet-2988	237	17	tunable	tunable	ADJ
admet-2988	237	18	surface	surface	NOUN
admet-2988	237	19	characteristics	characteristic	NOUN
admet-2988	237	20	,	,	PUNCT
admet-2988	237	21	high	high	ADJ
admet-2988	237	22	drug	drug	NOUN
admet-2988	237	23	loading	loading	NOUN
admet-2988	237	24	capacity	capacity	NOUN
admet-2988	237	25	,	,	PUNCT
admet-2988	237	26	and	and	CCONJ
admet-2988	237	27	controlled	control	VERB
admet-2988	237	28	drug	drug	NOUN
admet-2988	237	29	release	release	NOUN
admet-2988	237	30	[	[	X
admet-2988	237	31	20,46,66,67	20,46,66,67	NOUN
admet-2988	237	32	]	]	PUNCT
admet-2988	237	33	.	.	PUNCT
admet-2988	238	1	in	in	ADP
admet-2988	238	2	addition	addition	NOUN
admet-2988	238	3	,	,	PUNCT
admet-2988	238	4	nanotechnology	nanotechnology	NOUN
admet-2988	238	5	-	-	PUNCT
admet-2988	238	6	based	base	VERB
admet-2988	238	7	carriers	carrier	NOUN
admet-2988	238	8	can	can	AUX
admet-2988	238	9	minimize	minimize	VERB
admet-2988	238	10	adverse	adverse	ADJ
admet-2988	238	11	effects	effect	NOUN
admet-2988	238	12	[	[	X
admet-2988	238	13	21	21	NUM
admet-2988	238	14	]	]	PUNCT
admet-2988	238	15	and	and	CCONJ
admet-2988	238	16	improve	improve	VERB
admet-2988	238	17	biocompatibility	biocompatibility	NOUN
admet-2988	238	18	,	,	PUNCT
admet-2988	238	19	particularly	particularly	ADV
admet-2988	238	20	in	in	ADP
admet-2988	238	21	the	the	DET
admet-2988	238	22	case	case	NOUN
admet-2988	238	23	of	of	ADP
admet-2988	238	24	lipid	lipid	ADJ
admet-2988	238	25	nanoparticles	nanoparticle	NOUN
admet-2988	238	26	(	(	PUNCT
admet-2988	238	27	lnps	lnps	PROPN
admet-2988	238	28	)	)	PUNCT
admet-2988	239	1	[	[	X
admet-2988	239	2	96,97	96,97	PRON
admet-2988	239	3	]	]	PUNCT
admet-2988	239	4	.	.	PUNCT
admet-2988	240	1	many	many	ADJ
admet-2988	240	2	of	of	ADP
admet-2988	240	3	these	these	DET
admet-2988	240	4	features	feature	NOUN
admet-2988	240	5	are	be	AUX
admet-2988	240	6	also	also	ADV
admet-2988	240	7	advantageous	advantageous	ADJ
admet-2988	240	8	for	for	ADP
admet-2988	240	9	industrial	industrial	ADJ
admet-2988	240	10	-	-	PUNCT
admet-2988	240	11	scale	scale	NOUN
admet-2988	240	12	manufacturability	manufacturability	NOUN
admet-2988	240	13	[	[	X
admet-2988	240	14	98,99	98,99	NOUN
admet-2988	240	15	]	]	X
admet-2988	240	16	.	.	PUNCT
admet-2988	241	1	a	a	DET
admet-2988	241	2	wide	wide	ADJ
admet-2988	241	3	range	range	NOUN
admet-2988	241	4	of	of	ADP
admet-2988	241	5	nanocarriers	nanocarrier	NOUN
admet-2988	241	6	have	have	AUX
admet-2988	241	7	been	be	AUX
admet-2988	241	8	investigated	investigate	VERB
admet-2988	241	9	for	for	ADP
admet-2988	241	10	cns	cns	NOUN
admet-2988	241	11	drug	drug	NOUN
admet-2988	241	12	delivery	delivery	NOUN
admet-2988	241	13	,	,	PUNCT
admet-2988	241	14	including	include	VERB
admet-2988	241	15	nanoemulsions	nanoemulsion	NOUN
admet-2988	241	16	,	,	PUNCT
admet-2988	241	17	micelles	micelle	NOUN
admet-2988	241	18	,	,	PUNCT
admet-2988	241	19	liposomes	liposome	NOUN
admet-2988	241	20	,	,	PUNCT
admet-2988	241	21	nanofibers	nanofiber	NOUN
admet-2988	241	22	,	,	PUNCT
admet-2988	241	23	nanorobots	nanorobot	NOUN
admet-2988	241	24	,	,	PUNCT
admet-2988	241	25	polymeric	polymeric	ADJ
admet-2988	241	26	nanoparticles	nanoparticle	NOUN
admet-2988	241	27	,	,	PUNCT
admet-2988	241	28	solid	solid	ADJ
admet-2988	241	29	lipid	lipid	NOUN
admet-2988	241	30	nanoparticles	nanoparticle	NOUN
admet-2988	241	31	,	,	PUNCT
admet-2988	241	32	and	and	CCONJ
admet-2988	241	33	nanostructured	nanostructure	VERB
admet-2988	241	34	lipid	lipid	NOUN
admet-2988	241	35	carriers	carrier	NOUN
admet-2988	241	36	[	[	X
admet-2988	241	37	21	21	NUM
admet-2988	241	38	]	]	PUNCT
admet-2988	241	39	.	.	PUNCT
admet-2988	242	1	among	among	ADP
admet-2988	242	2	these	these	DET
admet-2988	242	3	,	,	PUNCT
admet-2988	242	4	polymeric	polymeric	ADJ
admet-2988	242	5	and	and	CCONJ
admet-2988	242	6	lipid	lipid	NOUN
admet-2988	242	7	-	-	PUNCT
admet-2988	242	8	based	base	VERB
admet-2988	242	9	nanoparticles	nanoparticle	NOUN
admet-2988	242	10	(	(	PUNCT
admet-2988	242	11	including	include	VERB
admet-2988	242	12	liposomes	liposome	NOUN
admet-2988	242	13	)	)	PUNCT
admet-2988	242	14	have	have	AUX
admet-2988	242	15	been	be	AUX
admet-2988	242	16	the	the	DET
admet-2988	242	17	most	most	ADV
admet-2988	242	18	extensively	extensively	ADV
admet-2988	242	19	studied	study	VERB
admet-2988	242	20	for	for	ADP
admet-2988	242	21	bbb	bbb	PROPN
admet-2988	242	22	transport	transport	NOUN
admet-2988	243	1	[	[	X
admet-2988	243	2	46	46	NUM
admet-2988	243	3	]	]	PUNCT
admet-2988	243	4	.	.	PUNCT
admet-2988	244	1	the	the	DET
admet-2988	244	2	use	use	NOUN
admet-2988	244	3	of	of	ADP
admet-2988	244	4	nanoparticles	nanoparticle	NOUN
admet-2988	244	5	,	,	PUNCT
admet-2988	244	6	particularly	particularly	ADV
admet-2988	244	7	lnps	lnps	PROPN
admet-2988	244	8	,	,	PUNCT
admet-2988	244	9	has	have	AUX
admet-2988	244	10	increased	increase	VERB
admet-2988	244	11	significantly	significantly	ADV
admet-2988	244	12	over	over	ADP
admet-2988	244	13	the	the	DET
admet-2988	244	14	past	past	ADJ
admet-2988	244	15	decade	decade	NOUN
admet-2988	244	16	as	as	ADP
admet-2988	244	17	a	a	DET
admet-2988	244	18	recognized	recognize	VERB
admet-2988	244	19	non	non	ADJ
admet-2988	244	20	-	-	ADJ
admet-2988	244	21	invasive	invasive	ADJ
admet-2988	244	22	strategy	strategy	NOUN
admet-2988	244	23	for	for	ADP
admet-2988	244	24	enhanced	enhanced	ADJ
admet-2988	244	25	drug	drug	NOUN
admet-2988	244	26	delivery	delivery	NOUN
admet-2988	244	27	across	across	ADP
admet-2988	244	28	the	the	DET
admet-2988	244	29	bbb	bbb	NOUN
admet-2988	244	30	[	[	X
admet-2988	244	31	19,70,100	19,70,100	NUM
admet-2988	244	32	-	-	SYM
admet-2988	244	33	103	103	NUM
admet-2988	244	34	]	]	PUNCT
admet-2988	244	35	.	.	PUNCT
admet-2988	245	1	due	due	ADP
admet-2988	245	2	to	to	ADP
admet-2988	245	3	their	their	PRON
admet-2988	245	4	lipid	lipid	NOUN
admet-2988	245	5	composition	composition	NOUN
admet-2988	245	6	,	,	PUNCT
admet-2988	245	7	these	these	DET
admet-2988	245	8	nanoparticles	nanoparticle	NOUN
admet-2988	245	9	exhibit	exhibit	VERB
admet-2988	245	10	a	a	DET
admet-2988	245	11	natural	natural	ADJ
admet-2988	245	12	propensity	propensity	NOUN
admet-2988	245	13	for	for	ADP
admet-2988	245	14	brain	brain	NOUN
admet-2988	245	15	uptake	uptake	NOUN
admet-2988	245	16	,	,	PUNCT
admet-2988	245	17	even	even	ADV
admet-2988	245	18	in	in	ADP
admet-2988	245	19	the	the	DET
admet-2988	245	20	absence	absence	NOUN
admet-2988	245	21	of	of	ADP
admet-2988	245	22	surface	surface	NOUN
admet-2988	245	23	modifications	modification	NOUN
admet-2988	245	24	for	for	ADP
admet-2988	245	25	active	active	ADJ
admet-2988	245	26	targeting	targeting	NOUN
admet-2988	245	27	.	.	PUNCT
admet-2988	246	1	however	however	ADV
admet-2988	246	2	,	,	PUNCT
admet-2988	246	3	some	some	DET
admet-2988	246	4	authors	author	NOUN
admet-2988	246	5	argue	argue	VERB
admet-2988	246	6	that	that	SCONJ
admet-2988	246	7	this	this	DET
admet-2988	246	8	passive	passive	ADJ
admet-2988	246	9	approach	approach	NOUN
admet-2988	246	10	lacks	lack	VERB
admet-2988	246	11	precision	precision	NOUN
admet-2988	246	12	and	and	CCONJ
admet-2988	246	13	control	control	NOUN
admet-2988	246	14	.	.	PUNCT
admet-2988	247	1	as	as	ADP
admet-2988	247	2	a	a	DET
admet-2988	247	3	result	result	NOUN
admet-2988	247	4	,	,	PUNCT
admet-2988	247	5	active	active	ADJ
admet-2988	247	6	targeting	targeting	NOUN
admet-2988	247	7	strategies	strategy	NOUN
admet-2988	247	8	have	have	AUX
admet-2988	247	9	gained	gain	VERB
admet-2988	247	10	attention	attention	NOUN
admet-2988	247	11	as	as	ADP
admet-2988	247	12	more	more	ADV
admet-2988	247	13	promising	promising	ADJ
admet-2988	247	14	and	and	CCONJ
admet-2988	247	15	reliable	reliable	ADJ
admet-2988	247	16	methods	method	NOUN
admet-2988	247	17	for	for	ADP
admet-2988	247	18	bbb	bbb	NOUN
admet-2988	247	19	penetration	penetration	NOUN
admet-2988	247	20	[	[	X
admet-2988	247	21	19,93,104,105	19,93,104,105	PROPN
admet-2988	247	22	]	]	PUNCT
admet-2988	247	23	.	.	PUNCT
admet-2988	248	1	advances	advance	NOUN
admet-2988	248	2	in	in	ADP
admet-2988	248	3	this	this	DET
admet-2988	248	4	area	area	NOUN
admet-2988	248	5	have	have	AUX
admet-2988	248	6	highlighted	highlight	VERB
admet-2988	248	7	peptides	peptide	NOUN
admet-2988	248	8	,	,	PUNCT
admet-2988	248	9	proteins	protein	NOUN
admet-2988	248	10	,	,	PUNCT
admet-2988	248	11	and	and	CCONJ
admet-2988	248	12	antibodies	antibodie	VERB
admet-2988	248	13	as	as	ADP
admet-2988	248	14	key	key	ADJ
admet-2988	248	15	strategies	strategy	NOUN
admet-2988	248	16	for	for	ADP
admet-2988	248	17	nanoparticle	nanoparticle	NOUN
admet-2988	248	18	functionalization	functionalization	NOUN
admet-2988	248	19	to	to	PART
admet-2988	248	20	enhance	enhance	VERB
admet-2988	248	21	bbb	bbb	PROPN
admet-2988	248	22	penetration	penetration	NOUN
admet-2988	248	23	[	[	X
admet-2988	248	24	19	19	NUM
admet-2988	248	25	]	]	PUNCT
admet-2988	248	26	via	via	ADP
admet-2988	248	27	receptor	receptor	NOUN
admet-2988	248	28	-	-	PUNCT
admet-2988	248	29	mediated	mediate	VERB
admet-2988	248	30	transcytosis	transcytosis	NOUN
admet-2988	248	31	[	[	X
admet-2988	248	32	29	29	NUM
admet-2988	248	33	]	]	PUNCT
admet-2988	248	34	.	.	PUNCT
admet-2988	249	1	other	other	ADJ
admet-2988	249	2	functionalization	functionalization	NOUN
admet-2988	249	3	approaches	approach	NOUN
admet-2988	249	4	have	have	AUX
admet-2988	249	5	been	be	AUX
admet-2988	249	6	explored	explore	VERB
admet-2988	249	7	,	,	PUNCT
admet-2988	249	8	including	include	VERB
admet-2988	249	9	the	the	DET
admet-2988	249	10	use	use	NOUN
admet-2988	249	11	of	of	ADP
admet-2988	249	12	aptamers	aptamer	NOUN
admet-2988	249	13	[	[	X
admet-2988	249	14	106	106	NUM
admet-2988	249	15	]	]	PUNCT
admet-2988	249	16	,	,	PUNCT
admet-2988	249	17	neurotransmitter	neurotransmitter	NOUN
admet-2988	249	18	-	-	PUNCT
admet-2988	249	19	derived	derive	VERB
admet-2988	249	20	lipids	lipid	NOUN
admet-2988	249	21	[	[	X
admet-2988	249	22	107	107	NUM
admet-2988	249	23	]	]	PUNCT
admet-2988	249	24	,	,	PUNCT
admet-2988	249	25	and	and	CCONJ
admet-2988	249	26	materials	material	NOUN
admet-2988	249	27	such	such	ADJ
admet-2988	249	28	as	as	ADP
admet-2988	249	29	menthol	menthol	NOUN
admet-2988	249	30	[	[	X
admet-2988	249	31	108	108	NUM
admet-2988	249	32	]	]	PUNCT
admet-2988	249	33	or	or	CCONJ
admet-2988	249	34	tocopherol	tocopherol	NOUN
admet-2988	249	35	derivatives	derivative	NOUN
admet-2988	249	36	[	[	X
admet-2988	249	37	109	109	NUM
admet-2988	249	38	]	]	PUNCT
admet-2988	249	39	.	.	PUNCT
admet-2988	250	1	combined	combine	VERB
admet-2988	250	2	strategies	strategy	NOUN
admet-2988	250	3	have	have	AUX
admet-2988	250	4	also	also	ADV
admet-2988	250	5	been	be	AUX
admet-2988	250	6	reported	report	VERB
admet-2988	250	7	,	,	PUNCT
admet-2988	250	8	such	such	ADJ
admet-2988	250	9	as	as	ADP
admet-2988	250	10	conjugation	conjugation	NOUN
admet-2988	250	11	of	of	ADP
admet-2988	250	12	peptides	peptide	NOUN
admet-2988	250	13	with	with	ADP
admet-2988	250	14	folic	folic	ADJ
admet-2988	250	15	acid	acid	NOUN
admet-2988	250	16	[	[	X
admet-2988	250	17	110	110	NUM
admet-2988	250	18	]	]	PUNCT
admet-2988	250	19	,	,	PUNCT
admet-2988	250	20	antibodies	antibodie	VERB
admet-2988	250	21	with	with	ADP
admet-2988	250	22	proteins	protein	NOUN
admet-2988	250	23	[	[	X
admet-2988	250	24	111	111	NUM
admet-2988	250	25	]	]	PUNCT
admet-2988	250	26	,	,	PUNCT
admet-2988	250	27	aptamers	aptamer	NOUN
admet-2988	250	28	with	with	ADP
admet-2988	250	29	peptides	peptide	NOUN
admet-2988	250	30	[	[	X
admet-2988	250	31	112	112	NUM
admet-2988	250	32	]	]	PUNCT
admet-2988	250	33	,	,	PUNCT
admet-2988	250	34	or	or	CCONJ
admet-2988	250	35	peptides	peptide	NOUN
admet-2988	250	36	with	with	ADP
admet-2988	250	37	biomimetic	biomimetic	ADJ
admet-2988	250	38	systems	system	NOUN
admet-2988	250	39	.	.	PUNCT
admet-2988	251	1	these	these	DET
admet-2988	251	2	biomimetic	biomimetic	ADJ
admet-2988	251	3	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	251	4	r.	r.	PROPN
admet-2988	251	5	vargas	vargas	PROPN
admet-2988	251	6	et	et	PROPN
admet-2988	251	7	al	al	PROPN
admet-2988	251	8	.	.	PROPN
admet-2988	251	9	admet	admet	PROPN
admet-2988	251	10	&	&	CCONJ
admet-2988	251	11	dmpk	dmpk	PROPN
admet-2988	251	12	13(5	13(5	NUM
admet-2988	251	13	)	)	PUNCT
admet-2988	251	14	(	(	PUNCT
admet-2988	251	15	2025	2025	NUM
admet-2988	251	16	)	)	PUNCT
admet-2988	251	17	2988	2988	NUM
admet-2988	251	18	12	12	NUM
admet-2988	251	19	systems	system	NOUN
admet-2988	251	20	provide	provide	VERB
admet-2988	251	21	an	an	DET
admet-2988	251	22	additional	additional	ADJ
admet-2988	251	23	approach	approach	NOUN
admet-2988	251	24	by	by	ADP
admet-2988	251	25	using	use	VERB
admet-2988	251	26	cell	cell	NOUN
admet-2988	251	27	-	-	PUNCT
admet-2988	251	28	mediated	mediate	VERB
admet-2988	251	29	transport	transport	NOUN
admet-2988	251	30	to	to	PART
admet-2988	251	31	improve	improve	VERB
admet-2988	251	32	bbb	bbb	NOUN
admet-2988	251	33	permeability	permeability	NOUN
admet-2988	251	34	[	[	X
admet-2988	251	35	113	113	NUM
admet-2988	251	36	]	]	PUNCT
admet-2988	251	37	.	.	PUNCT
admet-2988	252	1	figure	figure	NOUN
admet-2988	252	2	5	5	NUM
admet-2988	252	3	illustrates	illustrate	VERB
admet-2988	252	4	the	the	DET
admet-2988	252	5	distribution	distribution	NOUN
admet-2988	252	6	of	of	ADP
admet-2988	252	7	functionalization	functionalization	NOUN
admet-2988	252	8	strategies	strategy	NOUN
admet-2988	252	9	reported	report	VERB
admet-2988	252	10	between	between	ADP
admet-2988	252	11	2016	2016	NUM
admet-2988	252	12	and	and	CCONJ
admet-2988	252	13	july	july	PROPN
admet-2988	252	14	2024	2024	NUM
admet-2988	252	15	in	in	ADP
admet-2988	252	16	studies	study	NOUN
admet-2988	252	17	evaluating	evaluate	VERB
admet-2988	252	18	the	the	DET
admet-2988	252	19	efficacy	efficacy	NOUN
admet-2988	252	20	of	of	ADP
admet-2988	252	21	functionalized	functionalized	ADJ
admet-2988	252	22	nanoparticles	nanoparticle	NOUN
admet-2988	252	23	as	as	ADP
admet-2988	252	24	drug	drug	NOUN
admet-2988	252	25	carriers	carrier	NOUN
admet-2988	252	26	across	across	ADP
admet-2988	252	27	the	the	DET
admet-2988	252	28	bbb	bbb	NOUN
admet-2988	252	29	,	,	PUNCT
admet-2988	252	30	comparing	compare	VERB
admet-2988	252	31	their	their	PRON
admet-2988	252	32	results	result	NOUN
admet-2988	252	33	with	with	ADP
admet-2988	252	34	their	their	PRON
admet-2988	252	35	non	non	ADJ
admet-2988	252	36	-	-	ADJ
admet-2988	252	37	modified	modified	ADJ
admet-2988	252	38	counterparts	counterpart	NOUN
admet-2988	252	39	[	[	X
admet-2988	252	40	19	19	NUM
admet-2988	252	41	]	]	PUNCT
admet-2988	252	42	.	.	PUNCT
admet-2988	253	1	figure	figure	NOUN
admet-2988	253	2	5	5	NUM
admet-2988	253	3	.	.	PUNCT
admet-2988	253	4	functionalization	functionalization	NOUN
admet-2988	253	5	strategies	strategy	NOUN
admet-2988	253	6	for	for	SCONJ
admet-2988	253	7	lnps	lnps	NOUN
admet-2988	253	8	to	to	PART
admet-2988	253	9	cross	cross	VERB
admet-2988	253	10	the	the	DET
admet-2988	253	11	bbb	bbb	PROPN
admet-2988	253	12	.	.	PUNCT
admet-2988	254	1	this	this	DET
admet-2988	254	2	figure	figure	NOUN
admet-2988	254	3	illustrates	illustrate	VERB
admet-2988	254	4	the	the	DET
admet-2988	254	5	main	main	ADJ
admet-2988	254	6	functionalization	functionalization	NOUN
admet-2988	254	7	strategies	strategy	NOUN
admet-2988	254	8	employed	employ	VERB
admet-2988	254	9	to	to	PART
admet-2988	254	10	enhance	enhance	VERB
admet-2988	254	11	the	the	DET
admet-2988	254	12	transport	transport	NOUN
admet-2988	254	13	of	of	ADP
admet-2988	254	14	lnps	lnps	PROPN
admet-2988	254	15	across	across	ADP
admet-2988	254	16	the	the	DET
admet-2988	254	17	bbb	bbb	PROPN
admet-2988	254	18	.	.	PUNCT
admet-2988	255	1	notable	notable	ADJ
admet-2988	255	2	peptides	peptide	NOUN
admet-2988	255	3	include	include	VERB
admet-2988	255	4	transferrin	transferrin	NOUN
admet-2988	255	5	,	,	PUNCT
admet-2988	255	6	angiopep-2	angiopep-2	PROPN
admet-2988	255	7	,	,	PUNCT
admet-2988	255	8	and	and	CCONJ
admet-2988	255	9	an	an	DET
admet-2988	255	10	apolipoprotein	apolipoprotein	ADJ
admet-2988	255	11	e	e	NOUN
admet-2988	255	12	-	-	ADJ
admet-2988	255	13	derived	derived	ADJ
admet-2988	255	14	peptide	peptide	NOUN
admet-2988	255	15	.	.	PUNCT
admet-2988	256	1	among	among	ADP
admet-2988	256	2	proteins	protein	NOUN
admet-2988	256	3	,	,	PUNCT
admet-2988	256	4	apolipoprotein	apolipoprotein	ADJ
admet-2988	256	5	e	e	NOUN
admet-2988	256	6	and	and	CCONJ
admet-2988	256	7	lactoferrin	lactoferrin	NOUN
admet-2988	256	8	are	be	AUX
admet-2988	256	9	the	the	DET
admet-2988	256	10	most	most	ADV
admet-2988	256	11	frequently	frequently	ADV
admet-2988	256	12	used	use	VERB
admet-2988	256	13	,	,	PUNCT
admet-2988	256	14	while	while	SCONJ
admet-2988	256	15	transferrin	transferrin	NOUN
admet-2988	256	16	and	and	CCONJ
admet-2988	256	17	melanotransferrin	melanotransferrin	NOUN
admet-2988	256	18	-	-	PUNCT
admet-2988	256	19	targeting	target	VERB
admet-2988	256	20	antibodies	antibody	NOUN
admet-2988	256	21	are	be	AUX
admet-2988	256	22	predominant	predominant	ADJ
admet-2988	256	23	antibody	antibody	NOUN
admet-2988	256	24	-	-	PUNCT
admet-2988	256	25	based	base	VERB
admet-2988	256	26	strategies	strategy	NOUN
admet-2988	256	27	.	.	PUNCT
admet-2988	257	1	adapted	adapt	VERB
admet-2988	257	2	from	from	ADP
admet-2988	257	3	[	[	X
admet-2988	257	4	19	19	NUM
admet-2988	257	5	]	]	X
admet-2988	257	6	cc	cc	NOUN
admet-2988	257	7	-	-	PUNCT
admet-2988	257	8	by	by	ADP
admet-2988	257	9	-	-	PUNCT
admet-2988	257	10	nc	nc	VERB
admet-2988	257	11	-	-	PUNCT
admet-2988	257	12	nd	nd	ADV
admet-2988	257	13	current	current	ADJ
admet-2988	257	14	functionalization	functionalization	NOUN
admet-2988	257	15	approaches	approach	NOUN
admet-2988	257	16	show	show	VERB
admet-2988	257	17	a	a	DET
admet-2988	257	18	strong	strong	ADJ
admet-2988	257	19	preference	preference	NOUN
admet-2988	257	20	for	for	ADP
admet-2988	257	21	peptides	peptide	NOUN
admet-2988	257	22	as	as	ADP
admet-2988	257	23	the	the	DET
admet-2988	257	24	primary	primary	ADJ
admet-2988	257	25	strategy	strategy	NOUN
admet-2988	257	26	to	to	PART
admet-2988	257	27	facilitate	facilitate	VERB
admet-2988	257	28	nanoparticle	nanoparticle	NOUN
admet-2988	257	29	permeability	permeability	NOUN
admet-2988	257	30	across	across	ADP
admet-2988	257	31	the	the	DET
admet-2988	257	32	bbb	bbb	PROPN
admet-2988	257	33	.	.	PUNCT
admet-2988	258	1	these	these	DET
admet-2988	258	2	short	short	ADJ
admet-2988	258	3	amino	amino	NOUN
admet-2988	258	4	acid	acid	NOUN
admet-2988	258	5	sequences	sequence	NOUN
admet-2988	258	6	provide	provide	VERB
admet-2988	258	7	receptor	receptor	NOUN
admet-2988	258	8	specificity	specificity	NOUN
admet-2988	258	9	without	without	ADP
admet-2988	258	10	the	the	DET
admet-2988	258	11	immunogenicity	immunogenicity	NOUN
admet-2988	258	12	or	or	CCONJ
admet-2988	258	13	production	production	NOUN
admet-2988	258	14	complexity	complexity	NOUN
admet-2988	258	15	of	of	ADP
admet-2988	258	16	full	full	ADJ
admet-2988	258	17	proteins	protein	NOUN
admet-2988	258	18	[	[	X
admet-2988	258	19	104,114,115	104,114,115	NUM
admet-2988	258	20	]	]	PUNCT
admet-2988	258	21	.	.	PUNCT
admet-2988	259	1	several	several	ADJ
admet-2988	259	2	peptides	peptide	NOUN
admet-2988	259	3	have	have	AUX
admet-2988	259	4	been	be	AUX
admet-2988	259	5	extensively	extensively	ADV
admet-2988	259	6	studied	study	VERB
admet-2988	259	7	for	for	ADP
admet-2988	259	8	nanoparticle	nanoparticle	NOUN
admet-2988	259	9	functionalization	functionalization	NOUN
admet-2988	259	10	,	,	PUNCT
admet-2988	259	11	including	include	VERB
admet-2988	259	12	angiopep-2	angiopep-2	PROPN
admet-2988	259	13	,	,	PUNCT
admet-2988	259	14	the	the	DET
admet-2988	259	15	rabies	rabie	NOUN
admet-2988	259	16	virus	virus	NOUN
admet-2988	259	17	glycoprotein	glycoprotein	NOUN
admet-2988	259	18	(	(	PUNCT
admet-2988	259	19	rvg	rvg	NOUN
admet-2988	259	20	)	)	PUNCT
admet-2988	259	21	peptide	peptide	NOUN
admet-2988	259	22	,	,	PUNCT
admet-2988	259	23	transferrin	transferrin	NOUN
admet-2988	259	24	receptor	receptor	NOUN
admet-2988	259	25	-	-	PUNCT
admet-2988	259	26	targeting	target	VERB
admet-2988	259	27	peptides	peptide	NOUN
admet-2988	259	28	,	,	PUNCT
admet-2988	259	29	and	and	CCONJ
admet-2988	259	30	cell	cell	NOUN
admet-2988	259	31	-	-	PUNCT
admet-2988	259	32	penetrating	penetrate	VERB
admet-2988	259	33	peptides	peptide	NOUN
admet-2988	259	34	[	[	X
admet-2988	259	35	116	116	NUM
admet-2988	259	36	-	-	SYM
admet-2988	259	37	120	120	NUM
admet-2988	259	38	]	]	PUNCT
admet-2988	259	39	.	.	PUNCT
admet-2988	260	1	among	among	ADP
admet-2988	260	2	these	these	PRON
admet-2988	260	3	,	,	PUNCT
admet-2988	260	4	angiopep-2	angiopep-2	PROPN
admet-2988	260	5	was	be	AUX
admet-2988	260	6	one	one	NUM
admet-2988	260	7	of	of	ADP
admet-2988	260	8	the	the	DET
admet-2988	260	9	first	first	ADJ
admet-2988	260	10	to	to	PART
admet-2988	260	11	be	be	AUX
admet-2988	260	12	investigated	investigate	VERB
admet-2988	260	13	due	due	ADP
admet-2988	260	14	to	to	ADP
admet-2988	260	15	its	its	PRON
admet-2988	260	16	affinity	affinity	NOUN
admet-2988	260	17	for	for	ADP
admet-2988	260	18	low	low	ADJ
admet-2988	260	19	-	-	PUNCT
admet-2988	260	20	density	density	NOUN
admet-2988	260	21	lipoprotein	lipoprotein	ADJ
admet-2988	260	22	receptor	receptor	NOUN
admet-2988	260	23	-	-	PUNCT
admet-2988	260	24	related	relate	VERB
admet-2988	260	25	protein	protein	NOUN
admet-2988	260	26	1	1	NUM
admet-2988	260	27	(	(	PUNCT
admet-2988	260	28	lrp1	lrp1	PROPN
admet-2988	260	29	)	)	PUNCT
admet-2988	260	30	,	,	PUNCT
admet-2988	260	31	a	a	DET
admet-2988	260	32	key	key	ADJ
admet-2988	260	33	mediator	mediator	NOUN
admet-2988	260	34	in	in	ADP
admet-2988	260	35	lipid	lipid	NOUN
admet-2988	260	36	transport	transport	NOUN
admet-2988	260	37	and	and	CCONJ
admet-2988	260	38	brain	brain	NOUN
admet-2988	260	39	homeostasis	homeostasis	NOUN
admet-2988	260	40	[	[	X
admet-2988	260	41	116,121,122	116,121,122	NUM
admet-2988	260	42	]	]	PUNCT
admet-2988	260	43	.	.	PUNCT
admet-2988	261	1	the	the	DET
admet-2988	261	2	rvg	rvg	PROPN
admet-2988	261	3	peptide	peptide	NOUN
admet-2988	261	4	exhibits	exhibit	VERB
admet-2988	261	5	potent	potent	ADJ
admet-2988	261	6	neurotropism	neurotropism	NOUN
admet-2988	261	7	through	through	ADP
admet-2988	261	8	high	high	ADJ
admet-2988	261	9	-	-	PUNCT
admet-2988	261	10	affinity	affinity	NOUN
admet-2988	261	11	binding	bind	VERB
admet-2988	261	12	to	to	ADP
admet-2988	261	13	the	the	DET
admet-2988	261	14	acetylcholine	acetylcholine	NOUN
admet-2988	261	15	receptor	receptor	NOUN
admet-2988	261	16	,	,	PUNCT
admet-2988	261	17	enabling	enable	VERB
admet-2988	261	18	the	the	DET
admet-2988	261	19	first	first	ADJ
admet-2988	261	20	demonstration	demonstration	NOUN
admet-2988	261	21	of	of	ADP
admet-2988	261	22	peptide	peptide	NOUN
admet-2988	261	23	-	-	PUNCT
admet-2988	261	24	mediated	mediate	VERB
admet-2988	261	25	nucleic	nucleic	ADJ
admet-2988	261	26	acid	acid	NOUN
admet-2988	261	27	delivery	delivery	NOUN
admet-2988	261	28	to	to	ADP
admet-2988	261	29	the	the	DET
admet-2988	261	30	cns	cns	NOUN
admet-2988	261	31	in	in	ADP
admet-2988	261	32	2007	2007	NUM
admet-2988	261	33	[	[	X
admet-2988	261	34	118,123	118,123	NUM
admet-2988	261	35	]	]	PUNCT
admet-2988	261	36	.	.	PUNCT
admet-2988	262	1	the	the	DET
admet-2988	262	2	transferrin	transferrin	NOUN
admet-2988	262	3	receptor	receptor	NOUN
admet-2988	262	4	is	be	AUX
admet-2988	262	5	widely	widely	ADV
admet-2988	262	6	expressed	express	VERB
admet-2988	262	7	throughout	throughout	ADP
admet-2988	262	8	the	the	DET
admet-2988	262	9	body	body	NOUN
admet-2988	262	10	,	,	PUNCT
admet-2988	262	11	but	but	CCONJ
admet-2988	262	12	one	one	NUM
admet-2988	262	13	of	of	ADP
admet-2988	262	14	its	its	PRON
admet-2988	262	15	most	most	ADV
admet-2988	262	16	notable	notable	ADJ
admet-2988	262	17	applications	application	NOUN
admet-2988	262	18	is	be	AUX
admet-2988	262	19	as	as	ADP
admet-2988	262	20	a	a	DET
admet-2988	262	21	gateway	gateway	NOUN
admet-2988	262	22	to	to	ADP
admet-2988	262	23	the	the	DET
admet-2988	262	24	cns	cns	NOUN
admet-2988	263	1	[	[	X
admet-2988	263	2	119	119	NUM
admet-2988	263	3	]	]	PUNCT
admet-2988	263	4	.	.	PUNCT
admet-2988	264	1	the	the	DET
admet-2988	264	2	thr	thr	PROPN
admet-2988	264	3	peptide	peptide	NOUN
admet-2988	264	4	binds	bind	VERB
admet-2988	264	5	specifically	specifically	ADV
admet-2988	264	6	to	to	ADP
admet-2988	264	7	the	the	DET
admet-2988	264	8	human	human	ADJ
admet-2988	264	9	transferrin	transferrin	NOUN
admet-2988	264	10	receptor	receptor	NOUN
admet-2988	264	11	and	and	CCONJ
admet-2988	264	12	22.5	22.5	NUM
admet-2988	264	13	%	%	NOUN
admet-2988	264	14	11.25	11.25	NUM
admet-2988	264	15	%	%	NOUN
admet-2988	264	16	7.75	7.75	NUM
admet-2988	264	17	%	%	NOUN
admet-2988	264	18	15	15	NUM
admet-2988	264	19	%	%	NOUN
admet-2988	264	20	10	10	NUM
admet-2988	264	21	%	%	NOUN
admet-2988	264	22	10	10	NUM
admet-2988	264	23	%	%	NOUN
admet-2988	264	24	admet	admet	PROPN
admet-2988	264	25	&	&	CCONJ
admet-2988	264	26	dmpk	dmpk	PROPN
admet-2988	264	27	13(5	13(5	NOUN
admet-2988	264	28	)	)	PUNCT
admet-2988	264	29	(	(	PUNCT
admet-2988	264	30	2025	2025	NUM
admet-2988	264	31	)	)	PUNCT
admet-2988	264	32	2988	2988	NUM
admet-2988	264	33	advancing	advance	VERB
admet-2988	264	34	through	through	ADP
admet-2988	264	35	the	the	DET
admet-2988	264	36	blood	blood	NOUN
admet-2988	264	37	-	-	PUNCT
admet-2988	264	38	brain	brain	NOUN
admet-2988	264	39	barrier	barrier	NOUN
admet-2988	264	40	doi	doi	NOUN
admet-2988	264	41	:	:	PUNCT
admet-2988	264	42	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	264	43	13	13	NUM
admet-2988	264	44	enhances	enhance	NOUN
admet-2988	264	45	nanoparticle	nanoparticle	NOUN
admet-2988	264	46	transport	transport	NOUN
admet-2988	264	47	across	across	ADP
admet-2988	264	48	the	the	DET
admet-2988	264	49	bbb	bbb	NOUN
admet-2988	264	50	,	,	PUNCT
admet-2988	264	51	although	although	SCONJ
admet-2988	264	52	its	its	PRON
admet-2988	264	53	stability	stability	NOUN
admet-2988	264	54	is	be	AUX
admet-2988	264	55	limited	limit	VERB
admet-2988	264	56	by	by	ADP
admet-2988	264	57	its	its	PRON
admet-2988	264	58	susceptibility	susceptibility	NOUN
admet-2988	264	59	to	to	ADP
admet-2988	264	60	blood	blood	NOUN
admet-2988	264	61	proteases	protease	NOUN
admet-2988	264	62	.	.	PUNCT
admet-2988	265	1	the	the	DET
admet-2988	265	2	retro	retro	ADJ
admet-2988	265	3	-	-	PUNCT
admet-2988	265	4	enantiomeric	enantiomeric	ADJ
admet-2988	265	5	version	version	NOUN
admet-2988	265	6	(	(	PUNCT
admet-2988	265	7	thrre	thrre	PROPN
admet-2988	265	8	)	)	PUNCT
admet-2988	265	9	has	have	AUX
admet-2988	265	10	been	be	AUX
admet-2988	265	11	developed	develop	VERB
admet-2988	265	12	to	to	PART
admet-2988	265	13	improve	improve	VERB
admet-2988	265	14	serum	serum	NOUN
admet-2988	265	15	stability	stability	NOUN
admet-2988	265	16	and	and	CCONJ
admet-2988	265	17	transport	transport	NOUN
admet-2988	265	18	efficiency	efficiency	NOUN
admet-2988	265	19	,	,	PUNCT
admet-2988	265	20	representing	represent	VERB
admet-2988	265	21	a	a	DET
admet-2988	265	22	third	third	ADJ
admet-2988	265	23	-	-	PUNCT
admet-2988	265	24	generation	generation	NOUN
admet-2988	265	25	peptide	peptide	NOUN
admet-2988	265	26	with	with	ADP
admet-2988	265	27	enhanced	enhanced	ADJ
admet-2988	265	28	bbb	bbb	NOUN
admet-2988	265	29	penetration	penetration	NOUN
admet-2988	265	30	[	[	X
admet-2988	265	31	117,118	117,118	NUM
admet-2988	265	32	]	]	PUNCT
admet-2988	265	33	.	.	PUNCT
admet-2988	266	1	beyond	beyond	ADP
admet-2988	266	2	these	these	PRON
admet-2988	266	3	,	,	PUNCT
admet-2988	266	4	other	other	ADJ
admet-2988	266	5	peptides	peptide	NOUN
admet-2988	266	6	originally	originally	ADV
admet-2988	266	7	studied	study	VERB
admet-2988	266	8	as	as	SCONJ
admet-2988	266	9	transport	transport	NOUN
admet-2988	266	10	vectors	vector	NOUN
admet-2988	266	11	are	be	AUX
admet-2988	266	12	now	now	ADV
admet-2988	266	13	being	be	AUX
admet-2988	266	14	explored	explore	VERB
admet-2988	266	15	for	for	ADP
admet-2988	266	16	nanoparticle	nanoparticle	NOUN
admet-2988	266	17	functionalization	functionalization	NOUN
admet-2988	266	18	.	.	PUNCT
admet-2988	267	1	one	one	NUM
admet-2988	267	2	such	such	ADJ
admet-2988	267	3	example	example	NOUN
admet-2988	267	4	is	be	AUX
admet-2988	267	5	miniap-4	miniap-4	NUM
admet-2988	267	6	,	,	PUNCT
admet-2988	267	7	a	a	DET
admet-2988	267	8	cyclic	cyclic	ADJ
admet-2988	267	9	peptide	peptide	NOUN
admet-2988	267	10	derived	derive	VERB
admet-2988	267	11	from	from	ADP
admet-2988	267	12	apamin	apamin	NOUN
admet-2988	267	13	,	,	PUNCT
admet-2988	267	14	a	a	DET
admet-2988	267	15	neurotoxin	neurotoxin	NOUN
admet-2988	267	16	found	find	VERB
admet-2988	267	17	in	in	ADP
admet-2988	267	18	bee	bee	NOUN
admet-2988	267	19	venom	venom	NOUN
admet-2988	267	20	.	.	PUNCT
admet-2988	268	1	miniap-4	miniap-4	NUM
admet-2988	268	2	has	have	AUX
admet-2988	268	3	been	be	AUX
admet-2988	268	4	optimized	optimize	VERB
admet-2988	268	5	to	to	PART
admet-2988	268	6	reduce	reduce	VERB
admet-2988	268	7	complexity	complexity	NOUN
admet-2988	268	8	,	,	PUNCT
admet-2988	268	9	toxicity	toxicity	NOUN
admet-2988	268	10	,	,	PUNCT
admet-2988	268	11	and	and	CCONJ
admet-2988	268	12	immunogenicity	immunogenicity	NOUN
admet-2988	268	13	while	while	SCONJ
admet-2988	268	14	preserving	preserve	VERB
admet-2988	268	15	bbb	bbb	PROPN
admet-2988	268	16	targeting	target	VERB
admet-2988	268	17	,	,	PUNCT
admet-2988	268	18	active	active	ADJ
admet-2988	268	19	transport	transport	NOUN
admet-2988	268	20	,	,	PUNCT
admet-2988	268	21	and	and	CCONJ
admet-2988	268	22	protease	protease	NOUN
admet-2988	268	23	resistance	resistance	NOUN
admet-2988	268	24	.	.	PUNCT
admet-2988	269	1	miniap-4	miniap-4	VERB
admet-2988	270	1	represents	represent	VERB
admet-2988	270	2	a	a	DET
admet-2988	270	3	promising	promising	ADJ
admet-2988	270	4	candidate	candidate	NOUN
admet-2988	270	5	for	for	ADP
admet-2988	270	6	safe	safe	ADJ
admet-2988	270	7	and	and	CCONJ
admet-2988	270	8	efficient	efficient	ADJ
admet-2988	270	9	nanoparticle	nanoparticle	NOUN
admet-2988	270	10	-	-	PUNCT
admet-2988	270	11	based	base	VERB
admet-2988	270	12	brain	brain	NOUN
admet-2988	270	13	delivery	delivery	NOUN
admet-2988	271	1	[	[	X
admet-2988	271	2	124	124	NUM
admet-2988	271	3	]	]	PUNCT
admet-2988	271	4	.	.	PUNCT
admet-2988	272	1	methods	method	NOUN
admet-2988	272	2	for	for	ADP
admet-2988	272	3	evaluating	evaluate	VERB
admet-2988	272	4	blood	blood	NOUN
admet-2988	272	5	-	-	PUNCT
admet-2988	272	6	brain	brain	NOUN
admet-2988	272	7	barrier	barrier	NOUN
admet-2988	272	8	permeability	permeability	NOUN
admet-2988	272	9	successfully	successfully	ADV
admet-2988	272	10	translating	translate	VERB
admet-2988	272	11	cns	cns	NOUN
admet-2988	272	12	-	-	PUNCT
admet-2988	272	13	targeted	target	VERB
admet-2988	272	14	therapies	therapy	NOUN
admet-2988	272	15	into	into	ADP
admet-2988	272	16	clinical	clinical	ADJ
admet-2988	272	17	applications	application	NOUN
admet-2988	272	18	requires	require	VERB
admet-2988	272	19	thorough	thorough	ADJ
admet-2988	272	20	evaluation	evaluation	NOUN
admet-2988	272	21	.	.	PUNCT
admet-2988	273	1	the	the	DET
admet-2988	273	2	development	development	NOUN
admet-2988	273	3	and	and	CCONJ
admet-2988	273	4	optimization	optimization	NOUN
admet-2988	273	5	of	of	ADP
admet-2988	273	6	novel	novel	ADJ
admet-2988	273	7	transportation	transportation	NOUN
admet-2988	273	8	strategies	strategy	NOUN
admet-2988	273	9	must	must	AUX
admet-2988	273	10	be	be	AUX
admet-2988	273	11	accompanied	accompany	VERB
admet-2988	273	12	by	by	ADP
admet-2988	273	13	rigorous	rigorous	ADJ
admet-2988	273	14	permeability	permeability	NOUN
admet-2988	273	15	assessments	assessment	NOUN
admet-2988	273	16	to	to	PART
admet-2988	273	17	ensure	ensure	VERB
admet-2988	273	18	efficient	efficient	ADJ
admet-2988	273	19	drug	drug	NOUN
admet-2988	273	20	delivery	delivery	NOUN
admet-2988	273	21	to	to	ADP
admet-2988	273	22	the	the	DET
admet-2988	273	23	brain	brain	NOUN
admet-2988	274	1	[	[	X
admet-2988	274	2	125,126	125,126	NUM
admet-2988	274	3	]	]	PUNCT
admet-2988	274	4	.	.	PUNCT
admet-2988	275	1	various	various	ADJ
admet-2988	275	2	models	model	NOUN
admet-2988	275	3	are	be	AUX
admet-2988	275	4	available	available	ADJ
admet-2988	275	5	,	,	PUNCT
admet-2988	275	6	each	each	PRON
admet-2988	275	7	with	with	ADP
admet-2988	275	8	different	different	ADJ
admet-2988	275	9	levels	level	NOUN
admet-2988	275	10	of	of	ADP
admet-2988	275	11	complexity	complexity	NOUN
admet-2988	275	12	,	,	PUNCT
admet-2988	275	13	representativeness	representativeness	NOUN
admet-2988	275	14	,	,	PUNCT
admet-2988	275	15	and	and	CCONJ
admet-2988	275	16	applicability	applicability	NOUN
admet-2988	275	17	.	.	PUNCT
admet-2988	276	1	the	the	DET
admet-2988	276	2	selection	selection	NOUN
admet-2988	276	3	of	of	ADP
admet-2988	276	4	the	the	DET
admet-2988	276	5	model	model	NOUN
admet-2988	276	6	depends	depend	VERB
admet-2988	276	7	on	on	ADP
admet-2988	276	8	available	available	ADJ
admet-2988	276	9	resources	resource	NOUN
admet-2988	276	10	and	and	CCONJ
admet-2988	276	11	the	the	DET
admet-2988	276	12	specific	specific	ADJ
admet-2988	276	13	objectives	objective	NOUN
admet-2988	276	14	of	of	ADP
admet-2988	276	15	each	each	DET
admet-2988	276	16	study	study	NOUN
admet-2988	276	17	[	[	X
admet-2988	276	18	127,128	127,128	NUM
admet-2988	276	19	]	]	PUNCT
admet-2988	276	20	.	.	PUNCT
admet-2988	277	1	in	in	ADP
admet-2988	277	2	silico	silico	NOUN
admet-2988	277	3	models	model	NOUN
admet-2988	277	4	use	use	VERB
admet-2988	277	5	computational	computational	ADJ
admet-2988	277	6	tools	tool	NOUN
admet-2988	277	7	to	to	PART
admet-2988	277	8	generate	generate	VERB
admet-2988	277	9	rapid	rapid	ADJ
admet-2988	277	10	and	and	CCONJ
admet-2988	277	11	cost	cost	NOUN
admet-2988	277	12	-	-	PUNCT
admet-2988	277	13	effective	effective	ADJ
admet-2988	277	14	predictions	prediction	NOUN
admet-2988	277	15	of	of	ADP
admet-2988	277	16	passive	passive	ADJ
admet-2988	277	17	drug	drug	NOUN
admet-2988	277	18	transport	transport	NOUN
admet-2988	277	19	across	across	ADP
admet-2988	277	20	the	the	DET
admet-2988	277	21	bbb	bbb	NOUN
admet-2988	278	1	[	[	X
admet-2988	278	2	127,129	127,129	NUM
admet-2988	278	3	]	]	PUNCT
admet-2988	278	4	.	.	PUNCT
admet-2988	279	1	while	while	SCONJ
admet-2988	279	2	valuable	valuable	ADJ
admet-2988	279	3	in	in	ADP
admet-2988	279	4	early	early	ADJ
admet-2988	279	5	-	-	PUNCT
admet-2988	279	6	stage	stage	NOUN
admet-2988	279	7	development	development	NOUN
admet-2988	279	8	,	,	PUNCT
admet-2988	279	9	they	they	PRON
admet-2988	279	10	can	can	AUX
admet-2988	279	11	not	not	PART
admet-2988	279	12	fully	fully	ADV
admet-2988	279	13	replicate	replicate	VERB
admet-2988	279	14	the	the	DET
admet-2988	279	15	biological	biological	ADJ
admet-2988	279	16	,	,	PUNCT
admet-2988	279	17	molecular	molecular	ADJ
admet-2988	279	18	,	,	PUNCT
admet-2988	279	19	and	and	CCONJ
admet-2988	279	20	mechanical	mechanical	ADJ
admet-2988	279	21	complexity	complexity	NOUN
admet-2988	279	22	of	of	ADP
admet-2988	279	23	the	the	DET
admet-2988	279	24	bbb	bbb	NOUN
admet-2988	280	1	[	[	X
admet-2988	280	2	126	126	NUM
admet-2988	280	3	]	]	PUNCT
admet-2988	280	4	.	.	PUNCT
admet-2988	281	1	in	in	ADP
admet-2988	281	2	vitro	vitro	X
admet-2988	281	3	models	model	NOUN
admet-2988	281	4	,	,	PUNCT
admet-2988	281	5	based	base	VERB
admet-2988	281	6	on	on	ADP
admet-2988	281	7	primary	primary	ADJ
admet-2988	281	8	or	or	CCONJ
admet-2988	281	9	immortalized	immortalized	ADJ
admet-2988	281	10	cell	cell	NOUN
admet-2988	281	11	cultures	culture	NOUN
admet-2988	281	12	,	,	PUNCT
admet-2988	281	13	can	can	AUX
admet-2988	281	14	be	be	AUX
admet-2988	281	15	performed	perform	VERB
admet-2988	281	16	as	as	ADP
admet-2988	281	17	monocultures	monoculture	NOUN
admet-2988	281	18	or	or	CCONJ
admet-2988	281	19	co	co	NOUN
admet-2988	281	20	-	-	NOUN
admet-2988	281	21	cultures	culture	NOUN
admet-2988	281	22	with	with	ADP
admet-2988	281	23	other	other	ADJ
admet-2988	281	24	bbb	bbb	PROPN
admet-2988	281	25	components	component	NOUN
admet-2988	281	26	[	[	X
admet-2988	281	27	126,127	126,127	NUM
admet-2988	281	28	]	]	PUNCT
admet-2988	281	29	.	.	PUNCT
admet-2988	282	1	these	these	DET
admet-2988	282	2	models	model	NOUN
admet-2988	282	3	are	be	AUX
admet-2988	282	4	useful	useful	ADJ
admet-2988	282	5	for	for	ADP
admet-2988	282	6	evaluating	evaluate	VERB
admet-2988	282	7	compound	compound	NOUN
admet-2988	282	8	permeability	permeability	NOUN
admet-2988	282	9	;	;	PUNCT
admet-2988	282	10	however	however	ADV
admet-2988	282	11	,	,	PUNCT
admet-2988	282	12	their	their	PRON
admet-2988	282	13	correlation	correlation	NOUN
admet-2988	282	14	with	with	ADP
admet-2988	282	15	in	in	ADP
admet-2988	282	16	vivo	vivo	NOUN
admet-2988	282	17	models	model	NOUN
admet-2988	282	18	may	may	AUX
admet-2988	282	19	be	be	AUX
admet-2988	282	20	limited	limit	VERB
admet-2988	282	21	due	due	ADP
admet-2988	282	22	to	to	ADP
admet-2988	282	23	the	the	DET
admet-2988	282	24	simplification	simplification	NOUN
admet-2988	282	25	of	of	ADP
admet-2988	282	26	barrier	barrier	NOUN
admet-2988	282	27	physiology	physiology	NOUN
admet-2988	282	28	[	[	X
admet-2988	282	29	126,130	126,130	X
admet-2988	282	30	]	]	PUNCT
admet-2988	282	31	in	in	ADP
admet-2988	282	32	vivo	vivo	NOUN
admet-2988	282	33	models	model	NOUN
admet-2988	282	34	involve	involve	VERB
admet-2988	282	35	animal	animal	NOUN
admet-2988	282	36	studies	study	NOUN
admet-2988	282	37	using	use	VERB
admet-2988	282	38	primary	primary	ADJ
admet-2988	282	39	rodents	rodent	NOUN
admet-2988	282	40	,	,	PUNCT
admet-2988	282	41	zebrafish	zebrafish	ADJ
admet-2988	282	42	,	,	PUNCT
admet-2988	282	43	and	and	CCONJ
admet-2988	282	44	non	non	ADJ
admet-2988	282	45	-	-	ADJ
admet-2988	282	46	human	human	ADJ
admet-2988	282	47	primates	primate	NOUN
admet-2988	283	1	[	[	X
admet-2988	283	2	131	131	NUM
admet-2988	283	3	-	-	SYM
admet-2988	283	4	133	133	NUM
admet-2988	283	5	]	]	PUNCT
admet-2988	283	6	.	.	PUNCT
admet-2988	284	1	these	these	DET
admet-2988	284	2	models	model	NOUN
admet-2988	284	3	provide	provide	VERB
admet-2988	284	4	a	a	DET
admet-2988	284	5	complete	complete	ADJ
admet-2988	284	6	biological	biological	ADJ
admet-2988	284	7	system	system	NOUN
admet-2988	284	8	for	for	ADP
admet-2988	284	9	bbb	bbb	NOUN
admet-2988	284	10	permeability	permeability	NOUN
admet-2988	284	11	assessment	assessment	NOUN
admet-2988	284	12	but	but	CCONJ
admet-2988	284	13	raise	raise	VERB
admet-2988	284	14	ethical	ethical	ADJ
admet-2988	284	15	concerns	concern	NOUN
admet-2988	284	16	,	,	PUNCT
admet-2988	284	17	involve	involve	VERB
admet-2988	284	18	high	high	ADJ
admet-2988	284	19	costs	cost	NOUN
admet-2988	284	20	,	,	PUNCT
admet-2988	284	21	and	and	CCONJ
admet-2988	284	22	present	present	ADJ
admet-2988	284	23	interspecies	interspecie	NOUN
admet-2988	284	24	differences	difference	NOUN
admet-2988	284	25	that	that	PRON
admet-2988	284	26	complicate	complicate	VERB
admet-2988	284	27	translation	translation	NOUN
admet-2988	284	28	to	to	ADP
admet-2988	284	29	human	human	ADJ
admet-2988	284	30	physiology	physiology	NOUN
admet-2988	284	31	[	[	X
admet-2988	284	32	127	127	NUM
admet-2988	284	33	]	]	PUNCT
admet-2988	284	34	.	.	PUNCT
admet-2988	285	1	an	an	DET
admet-2988	285	2	emerging	emerge	VERB
admet-2988	285	3	alternative	alternative	NOUN
admet-2988	285	4	is	be	AUX
admet-2988	285	5	organ	organ	NOUN
admet-2988	285	6	-	-	PUNCT
admet-2988	285	7	on	on	ADP
admet-2988	285	8	-	-	PUNCT
admet-2988	285	9	a	a	DET
admet-2988	285	10	-	-	PUNCT
admet-2988	285	11	chip	chip	NOUN
admet-2988	285	12	(	(	PUNCT
admet-2988	285	13	ooc	ooc	NOUN
admet-2988	285	14	)	)	PUNCT
admet-2988	285	15	technology	technology	NOUN
admet-2988	285	16	,	,	PUNCT
admet-2988	285	17	which	which	PRON
admet-2988	285	18	integrates	integrate	VERB
admet-2988	285	19	microfluidics	microfluidic	NOUN
admet-2988	285	20	and	and	CCONJ
admet-2988	285	21	3d	3d	NUM
admet-2988	285	22	cell	cell	NOUN
admet-2988	285	23	cultures	culture	NOUN
admet-2988	285	24	to	to	PART
admet-2988	285	25	more	more	ADV
admet-2988	285	26	accurately	accurately	ADV
admet-2988	285	27	replicate	replicate	VERB
admet-2988	285	28	the	the	DET
admet-2988	285	29	architecture	architecture	NOUN
admet-2988	285	30	and	and	CCONJ
admet-2988	285	31	physiological	physiological	ADJ
admet-2988	285	32	conditions	condition	NOUN
admet-2988	285	33	of	of	ADP
admet-2988	285	34	the	the	DET
admet-2988	285	35	in	in	ADP
admet-2988	285	36	vivo	vivo	ADJ
admet-2988	285	37	environment	environment	NOUN
admet-2988	285	38	[	[	X
admet-2988	285	39	134	134	NUM
admet-2988	285	40	-	-	SYM
admet-2988	285	41	136	136	NUM
admet-2988	285	42	]	]	PUNCT
admet-2988	285	43	.	.	PUNCT
admet-2988	286	1	these	these	DET
admet-2988	286	2	systems	system	NOUN
admet-2988	286	3	offer	offer	VERB
admet-2988	286	4	enhanced	enhance	VERB
admet-2988	286	5	cellular	cellular	ADJ
admet-2988	286	6	differentiation	differentiation	NOUN
admet-2988	286	7	and	and	CCONJ
admet-2988	286	8	more	more	ADV
admet-2988	286	9	physiologically	physiologically	ADV
admet-2988	286	10	relevant	relevant	ADJ
admet-2988	286	11	responses	response	NOUN
admet-2988	286	12	,	,	PUNCT
admet-2988	286	13	making	make	VERB
admet-2988	286	14	them	they	PRON
admet-2988	286	15	highly	highly	ADV
admet-2988	286	16	representative	representative	ADJ
admet-2988	286	17	research	research	NOUN
admet-2988	286	18	tools	tool	NOUN
admet-2988	286	19	.	.	PUNCT
admet-2988	287	1	by	by	ADP
admet-2988	287	2	recapitulating	recapitulate	VERB
admet-2988	287	3	key	key	ADJ
admet-2988	287	4	barrier	barrier	NOUN
admet-2988	287	5	functions	function	NOUN
admet-2988	287	6	,	,	PUNCT
admet-2988	287	7	ooc	ooc	NOUN
admet-2988	287	8	models	model	NOUN
admet-2988	287	9	provide	provide	VERB
admet-2988	287	10	a	a	DET
admet-2988	287	11	promising	promising	ADJ
admet-2988	287	12	bridge	bridge	NOUN
admet-2988	287	13	between	between	ADP
admet-2988	287	14	in	in	ADP
admet-2988	287	15	vitro	vitro	X
admet-2988	287	16	and	and	CCONJ
admet-2988	287	17	in	in	ADP
admet-2988	287	18	vivo	vivo	ADJ
admet-2988	287	19	systems	system	NOUN
admet-2988	287	20	for	for	ADP
admet-2988	287	21	bbb	bbb	PROPN
admet-2988	287	22	evaluation	evaluation	NOUN
admet-2988	287	23	[	[	X
admet-2988	287	24	136,137	136,137	NUM
admet-2988	287	25	]	]	PUNCT
admet-2988	287	26	.	.	PUNCT
admet-2988	288	1	however	however	ADV
admet-2988	288	2	,	,	PUNCT
admet-2988	288	3	further	further	ADJ
admet-2988	288	4	validation	validation	NOUN
admet-2988	288	5	and	and	CCONJ
admet-2988	288	6	optimization	optimization	NOUN
admet-2988	288	7	are	be	AUX
admet-2988	288	8	still	still	ADV
admet-2988	288	9	needed	need	VERB
admet-2988	288	10	to	to	PART
admet-2988	288	11	ensure	ensure	VERB
admet-2988	288	12	robustness	robustness	NOUN
admet-2988	288	13	and	and	CCONJ
admet-2988	288	14	reproducibility	reproducibility	NOUN
admet-2988	288	15	[	[	X
admet-2988	288	16	126	126	NUM
admet-2988	288	17	]	]	PUNCT
admet-2988	288	18	.	.	PUNCT
admet-2988	289	1	regardless	regardless	ADV
admet-2988	289	2	of	of	ADP
admet-2988	289	3	the	the	DET
admet-2988	289	4	model	model	NOUN
admet-2988	289	5	used	use	VERB
admet-2988	289	6	,	,	PUNCT
admet-2988	289	7	proper	proper	ADJ
admet-2988	289	8	validation	validation	NOUN
admet-2988	289	9	is	be	AUX
admet-2988	289	10	essential	essential	ADJ
admet-2988	289	11	to	to	PART
admet-2988	289	12	ensure	ensure	VERB
admet-2988	289	13	clinical	clinical	ADJ
admet-2988	289	14	relevance	relevance	NOUN
admet-2988	289	15	.	.	PUNCT
admet-2988	290	1	while	while	SCONJ
admet-2988	290	2	a	a	DET
admet-2988	290	3	detailed	detailed	ADJ
admet-2988	290	4	discussion	discussion	NOUN
admet-2988	290	5	of	of	ADP
admet-2988	290	6	each	each	DET
admet-2988	290	7	method	method	NOUN
admet-2988	290	8	is	be	AUX
admet-2988	290	9	beyond	beyond	ADP
admet-2988	290	10	the	the	DET
admet-2988	290	11	scope	scope	NOUN
admet-2988	290	12	of	of	ADP
admet-2988	290	13	this	this	DET
admet-2988	290	14	article	article	NOUN
admet-2988	290	15	,	,	PUNCT
admet-2988	290	16	readers	reader	NOUN
admet-2988	290	17	are	be	AUX
admet-2988	290	18	encouraged	encourage	VERB
admet-2988	290	19	to	to	PART
admet-2988	290	20	consult	consult	VERB
admet-2988	290	21	existing	exist	VERB
admet-2988	290	22	reviews	review	NOUN
admet-2988	290	23	for	for	ADP
admet-2988	290	24	a	a	DET
admet-2988	290	25	more	more	ADV
admet-2988	290	26	comprehensive	comprehensive	ADJ
admet-2988	290	27	analysis	analysis	NOUN
admet-2988	290	28	of	of	ADP
admet-2988	290	29	their	their	PRON
admet-2988	290	30	principles	principle	NOUN
admet-2988	290	31	,	,	PUNCT
admet-2988	290	32	advantages	advantage	NOUN
admet-2988	290	33	,	,	PUNCT
admet-2988	290	34	and	and	CCONJ
admet-2988	290	35	limitations	limitation	NOUN
admet-2988	290	36	.	.	PUNCT
admet-2988	291	1	as	as	SCONJ
admet-2988	291	2	research	research	NOUN
admet-2988	291	3	on	on	ADP
admet-2988	291	4	the	the	DET
admet-2988	291	5	bbb	bbb	PROPN
admet-2988	291	6	continues	continue	VERB
admet-2988	291	7	to	to	PART
admet-2988	291	8	advance	advance	VERB
admet-2988	291	9	,	,	PUNCT
admet-2988	291	10	it	it	PRON
admet-2988	291	11	lays	lay	VERB
admet-2988	291	12	the	the	DET
admet-2988	291	13	groundwork	groundwork	NOUN
admet-2988	291	14	for	for	ADP
admet-2988	291	15	the	the	DET
admet-2988	291	16	development	development	NOUN
admet-2988	291	17	of	of	ADP
admet-2988	291	18	novel	novel	ADJ
admet-2988	291	19	therapeutic	therapeutic	ADJ
admet-2988	291	20	strategies	strategy	NOUN
admet-2988	291	21	.	.	PUNCT
admet-2988	292	1	discussion	discussion	NOUN
admet-2988	292	2	drug	drug	NOUN
admet-2988	292	3	delivery	delivery	NOUN
admet-2988	292	4	to	to	ADP
admet-2988	292	5	the	the	DET
admet-2988	292	6	cns	cns	NOUN
admet-2988	292	7	is	be	AUX
admet-2988	292	8	an	an	DET
admet-2988	292	9	interdisciplinary	interdisciplinary	ADJ
admet-2988	292	10	field	field	NOUN
admet-2988	292	11	that	that	PRON
admet-2988	292	12	requires	require	VERB
admet-2988	292	13	both	both	CCONJ
admet-2988	292	14	incremental	incremental	ADJ
admet-2988	292	15	and	and	CCONJ
admet-2988	292	16	synergistic	synergistic	ADJ
admet-2988	292	17	advances	advance	NOUN
admet-2988	292	18	.	.	PUNCT
admet-2988	293	1	the	the	DET
admet-2988	293	2	complexity	complexity	NOUN
admet-2988	293	3	of	of	ADP
admet-2988	293	4	the	the	DET
admet-2988	293	5	bbb	bbb	PROPN
admet-2988	293	6	implies	imply	VERB
admet-2988	293	7	that	that	SCONJ
admet-2988	293	8	optimizing	optimize	VERB
admet-2988	293	9	brain	brain	NOUN
admet-2988	293	10	-	-	PUNCT
admet-2988	293	11	targeted	target	VERB
admet-2988	293	12	therapies	therapy	NOUN
admet-2988	293	13	demands	demand	VERB
admet-2988	293	14	progress	progress	NOUN
admet-2988	293	15	across	across	ADP
admet-2988	293	16	multiple	multiple	ADJ
admet-2988	293	17	disciplines	discipline	NOUN
admet-2988	293	18	,	,	PUNCT
admet-2988	293	19	including	include	VERB
admet-2988	293	20	physiology	physiology	NOUN
admet-2988	293	21	,	,	PUNCT
admet-2988	293	22	materials	material	NOUN
admet-2988	293	23	science	science	NOUN
admet-2988	293	24	,	,	PUNCT
admet-2988	293	25	bioengineering	bioengineering	NOUN
admet-2988	293	26	,	,	PUNCT
admet-2988	293	27	and	and	CCONJ
admet-2988	293	28	pharmacology	pharmacology	NOUN
admet-2988	293	29	.	.	PUNCT
admet-2988	294	1	successfully	successfully	ADV
admet-2988	294	2	bypassing	bypass	VERB
admet-2988	294	3	this	this	DET
admet-2988	294	4	barrier	barrier	NOUN
admet-2988	294	5	requires	require	VERB
admet-2988	294	6	a	a	DET
admet-2988	294	7	profound	profound	ADJ
admet-2988	294	8	understanding	understanding	NOUN
admet-2988	294	9	of	of	ADP
admet-2988	294	10	the	the	DET
admet-2988	294	11	bbb	bbb	NOUN
admet-2988	294	12	,	,	PUNCT
admet-2988	294	13	not	not	PART
admet-2988	294	14	only	only	ADV
admet-2988	294	15	its	its	PRON
admet-2988	294	16	anatomical	anatomical	ADJ
admet-2988	294	17	structure	structure	NOUN
admet-2988	294	18	,	,	PUNCT
admet-2988	294	19	but	but	CCONJ
admet-2988	294	20	also	also	ADV
admet-2988	294	21	its	its	PRON
admet-2988	294	22	dynamic	dynamic	ADJ
admet-2988	294	23	modulation	modulation	NOUN
admet-2988	294	24	,	,	PUNCT
admet-2988	294	25	intercellular	intercellular	ADJ
admet-2988	294	26	communication	communication	NOUN
admet-2988	294	27	,	,	PUNCT
admet-2988	294	28	and	and	CCONJ
admet-2988	294	29	transport	transport	NOUN
admet-2988	294	30	mechanisms	mechanism	NOUN
admet-2988	294	31	.	.	PUNCT
admet-2988	295	1	these	these	DET
admet-2988	295	2	processes	process	NOUN
admet-2988	295	3	define	define	VERB
admet-2988	295	4	the	the	DET
admet-2988	295	5	bbb	bbb	NOUN
admet-2988	295	6	's	's	PART
admet-2988	295	7	selective	selective	ADJ
admet-2988	295	8	permeability	permeability	NOUN
admet-2988	295	9	and	and	CCONJ
admet-2988	295	10	determine	determine	VERB
admet-2988	295	11	how	how	SCONJ
admet-2988	295	12	pharmacological	pharmacological	ADJ
admet-2988	295	13	agents	agent	NOUN
admet-2988	295	14	interact	interact	VERB
admet-2988	295	15	with	with	ADP
admet-2988	295	16	and	and	CCONJ
admet-2988	295	17	cross	cross	VERB
admet-2988	295	18	the	the	DET
admet-2988	295	19	barrier	barrier	NOUN
admet-2988	295	20	to	to	PART
admet-2988	295	21	achieve	achieve	VERB
admet-2988	295	22	effective	effective	ADJ
admet-2988	295	23	delivery	delivery	NOUN
admet-2988	295	24	while	while	SCONJ
admet-2988	295	25	preserving	preserve	VERB
admet-2988	295	26	cns	cns	NOUN
admet-2988	295	27	homeostasis	homeostasis	NOUN
admet-2988	295	28	.	.	PUNCT
admet-2988	296	1	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	296	2	r.	r.	PROPN
admet-2988	296	3	vargas	vargas	PROPN
admet-2988	296	4	et	et	PROPN
admet-2988	296	5	al	al	PROPN
admet-2988	296	6	.	.	PROPN
admet-2988	296	7	admet	admet	PROPN
admet-2988	296	8	&	&	CCONJ
admet-2988	296	9	dmpk	dmpk	PROPN
admet-2988	296	10	13(5	13(5	NUM
admet-2988	296	11	)	)	PUNCT
admet-2988	296	12	(	(	PUNCT
admet-2988	296	13	2025	2025	NUM
admet-2988	296	14	)	)	PUNCT
admet-2988	296	15	2988	2988	NUM
admet-2988	296	16	14	14	NUM
admet-2988	296	17	the	the	DET
admet-2988	296	18	challenges	challenge	NOUN
admet-2988	296	19	of	of	ADP
admet-2988	296	20	delivering	deliver	VERB
admet-2988	296	21	therapeutics	therapeutic	NOUN
admet-2988	296	22	across	across	ADP
admet-2988	296	23	the	the	DET
admet-2988	296	24	bbb	bbb	NOUN
admet-2988	296	25	are	be	AUX
admet-2988	296	26	becoming	become	VERB
admet-2988	296	27	increasingly	increasingly	ADV
admet-2988	296	28	critical	critical	ADJ
admet-2988	296	29	as	as	SCONJ
admet-2988	296	30	recent	recent	ADJ
admet-2988	296	31	therapeutic	therapeutic	ADJ
admet-2988	296	32	strategies	strategy	NOUN
admet-2988	296	33	shift	shift	VERB
admet-2988	296	34	from	from	ADP
admet-2988	296	35	small	small	ADJ
admet-2988	296	36	molecules	molecule	NOUN
admet-2988	296	37	to	to	ADP
admet-2988	296	38	biological	biological	ADJ
admet-2988	296	39	macromolecules	macromolecule	NOUN
admet-2988	296	40	and	and	CCONJ
admet-2988	296	41	nucleic	nucleic	ADJ
admet-2988	296	42	acid	acid	NOUN
admet-2988	296	43	-	-	PUNCT
admet-2988	296	44	based	base	VERB
admet-2988	296	45	approaches	approach	NOUN
admet-2988	296	46	,	,	PUNCT
admet-2988	296	47	which	which	PRON
admet-2988	296	48	face	face	VERB
admet-2988	296	49	even	even	ADV
admet-2988	296	50	greater	great	ADJ
admet-2988	296	51	obstacles	obstacle	NOUN
admet-2988	296	52	for	for	ADP
admet-2988	296	53	entry	entry	NOUN
admet-2988	296	54	into	into	ADP
admet-2988	296	55	the	the	DET
admet-2988	296	56	cns	cns	NOUN
admet-2988	296	57	.	.	PUNCT
admet-2988	297	1	the	the	DET
admet-2988	297	2	growing	grow	VERB
admet-2988	297	3	interest	interest	NOUN
admet-2988	297	4	in	in	ADP
admet-2988	297	5	rna	rna	NOUN
admet-2988	297	6	-	-	PUNCT
admet-2988	297	7	based	base	VERB
admet-2988	297	8	therapeutics	therapeutic	NOUN
admet-2988	297	9	and	and	CCONJ
admet-2988	297	10	gene	gene	NOUN
admet-2988	297	11	modulation	modulation	NOUN
admet-2988	297	12	strategies	strategy	NOUN
admet-2988	297	13	for	for	ADP
admet-2988	297	14	neurological	neurological	ADJ
admet-2988	297	15	disorders	disorder	NOUN
admet-2988	297	16	exemplifies	exemplify	VERB
admet-2988	297	17	this	this	DET
admet-2988	297	18	paradigm	paradigm	NOUN
admet-2988	297	19	shift	shift	NOUN
admet-2988	297	20	and	and	CCONJ
admet-2988	297	21	underscores	underscore	VERB
admet-2988	297	22	the	the	DET
admet-2988	297	23	urgent	urgent	ADJ
admet-2988	297	24	need	need	NOUN
admet-2988	297	25	for	for	ADP
admet-2988	297	26	innovative	innovative	ADJ
admet-2988	297	27	delivery	delivery	NOUN
admet-2988	297	28	approaches	approach	NOUN
admet-2988	297	29	to	to	PART
admet-2988	297	30	ensure	ensure	VERB
admet-2988	297	31	effective	effective	ADJ
admet-2988	297	32	brain	brain	NOUN
admet-2988	297	33	targeting	targeting	NOUN
admet-2988	297	34	.	.	PUNCT
admet-2988	298	1	this	this	DET
admet-2988	298	2	review	review	NOUN
admet-2988	298	3	has	have	AUX
admet-2988	298	4	compiled	compile	VERB
admet-2988	298	5	and	and	CCONJ
admet-2988	298	6	analysed	analyse	VERB
admet-2988	298	7	a	a	DET
admet-2988	298	8	wide	wide	ADJ
admet-2988	298	9	range	range	NOUN
admet-2988	298	10	of	of	ADP
admet-2988	298	11	strategies	strategy	NOUN
admet-2988	298	12	to	to	PART
admet-2988	298	13	overcome	overcome	VERB
admet-2988	298	14	the	the	DET
admet-2988	298	15	bbb	bbb	PROPN
admet-2988	298	16	,	,	PUNCT
admet-2988	298	17	from	from	ADP
admet-2988	298	18	passive	passive	ADJ
admet-2988	298	19	diffusion	diffusion	NOUN
admet-2988	298	20	enhancers	enhancer	NOUN
admet-2988	298	21	to	to	ADP
admet-2988	298	22	active	active	ADJ
admet-2988	298	23	targeting	targeting	NOUN
admet-2988	298	24	mechanisms	mechanism	NOUN
admet-2988	298	25	involving	involve	VERB
admet-2988	298	26	ligand	ligand	ADJ
admet-2988	298	27	functionalization	functionalization	NOUN
admet-2988	298	28	.	.	PUNCT
admet-2988	299	1	a	a	DET
admet-2988	299	2	comparative	comparative	ADJ
admet-2988	299	3	analysis	analysis	NOUN
admet-2988	299	4	of	of	ADP
admet-2988	299	5	these	these	DET
admet-2988	299	6	approaches	approach	NOUN
admet-2988	299	7	reveals	reveal	VERB
admet-2988	299	8	key	key	ADJ
admet-2988	299	9	patterns	pattern	NOUN
admet-2988	299	10	in	in	ADP
admet-2988	299	11	their	their	PRON
admet-2988	299	12	effectiveness	effectiveness	NOUN
admet-2988	299	13	and	and	CCONJ
admet-2988	299	14	limitations	limitation	NOUN
admet-2988	299	15	,	,	PUNCT
admet-2988	299	16	providing	provide	VERB
admet-2988	299	17	valuable	valuable	ADJ
admet-2988	299	18	insights	insight	NOUN
admet-2988	299	19	into	into	ADP
admet-2988	299	20	their	their	PRON
admet-2988	299	21	translational	translational	ADJ
admet-2988	299	22	potential	potential	NOUN
admet-2988	299	23	.	.	PUNCT
admet-2988	300	1	particular	particular	ADJ
admet-2988	300	2	attention	attention	NOUN
admet-2988	300	3	has	have	AUX
admet-2988	300	4	been	be	AUX
admet-2988	300	5	given	give	VERB
admet-2988	300	6	to	to	ADP
admet-2988	300	7	nanotechnology	nanotechnology	NOUN
admet-2988	300	8	-	-	PUNCT
admet-2988	300	9	based	base	VERB
admet-2988	300	10	systems	system	NOUN
admet-2988	300	11	,	,	PUNCT
admet-2988	300	12	especially	especially	ADV
admet-2988	300	13	lnps	lnps	PROPN
admet-2988	300	14	,	,	PUNCT
admet-2988	300	15	due	due	ADP
admet-2988	300	16	to	to	ADP
admet-2988	300	17	their	their	PRON
admet-2988	300	18	versatility	versatility	NOUN
admet-2988	300	19	and	and	CCONJ
admet-2988	300	20	promise	promise	NOUN
admet-2988	300	21	in	in	ADP
admet-2988	300	22	cns	cns	NOUN
admet-2988	300	23	drug	drug	NOUN
admet-2988	300	24	delivery	delivery	NOUN
admet-2988	300	25	.	.	PUNCT
admet-2988	301	1	lnps	lnps	PROPN
admet-2988	301	2	have	have	AUX
admet-2988	301	3	emerged	emerge	VERB
admet-2988	301	4	as	as	ADP
admet-2988	301	5	a	a	DET
admet-2988	301	6	relatively	relatively	ADV
admet-2988	301	7	safe	safe	ADJ
admet-2988	301	8	and	and	CCONJ
admet-2988	301	9	versatile	versatile	ADJ
admet-2988	301	10	platform	platform	NOUN
admet-2988	301	11	,	,	PUNCT
admet-2988	301	12	owing	owe	VERB
admet-2988	301	13	to	to	ADP
admet-2988	301	14	their	their	PRON
admet-2988	301	15	structural	structural	ADJ
admet-2988	301	16	resemblance	resemblance	NOUN
admet-2988	301	17	to	to	ADP
admet-2988	301	18	biological	biological	ADJ
admet-2988	301	19	membranes	membrane	NOUN
admet-2988	301	20	.	.	PUNCT
admet-2988	302	1	they	they	PRON
admet-2988	302	2	provide	provide	VERB
admet-2988	302	3	protection	protection	NOUN
admet-2988	302	4	and	and	CCONJ
admet-2988	302	5	controlled	control	VERB
admet-2988	302	6	release	release	NOUN
admet-2988	302	7	of	of	ADP
admet-2988	302	8	therapeutic	therapeutic	ADJ
admet-2988	302	9	agents	agent	NOUN
admet-2988	302	10	and	and	CCONJ
admet-2988	302	11	can	can	AUX
admet-2988	302	12	be	be	AUX
admet-2988	302	13	surface	surface	NOUN
admet-2988	302	14	-	-	PUNCT
admet-2988	302	15	functionalized	functionalized	ADJ
admet-2988	302	16	to	to	PART
admet-2988	302	17	enhance	enhance	VERB
admet-2988	302	18	interactions	interaction	NOUN
admet-2988	302	19	with	with	ADP
admet-2988	302	20	biological	biological	ADJ
admet-2988	302	21	barriers	barrier	NOUN
admet-2988	302	22	.	.	PUNCT
admet-2988	303	1	functionalization	functionalization	NOUN
admet-2988	303	2	strategies	strategy	NOUN
admet-2988	303	3	—	—	PUNCT
admet-2988	303	4	such	such	ADJ
admet-2988	303	5	as	as	ADP
admet-2988	303	6	those	those	PRON
admet-2988	303	7	involving	involve	VERB
admet-2988	303	8	angiopep-2	angiopep-2	PROPN
admet-2988	303	9	and	and	CCONJ
admet-2988	303	10	transferring	transfer	VERB
admet-2988	303	11	receptor	receptor	NOUN
admet-2988	303	12	-	-	PUNCT
admet-2988	303	13	targeting	target	VERB
admet-2988	303	14	peptides	peptide	NOUN
admet-2988	303	15	—	—	PUNCT
admet-2988	303	16	have	have	AUX
admet-2988	303	17	demonstrated	demonstrate	VERB
admet-2988	303	18	potential	potential	NOUN
admet-2988	303	19	to	to	PART
admet-2988	303	20	improve	improve	VERB
admet-2988	303	21	bbb	bbb	NOUN
admet-2988	303	22	permeability	permeability	NOUN
admet-2988	303	23	.	.	PUNCT
admet-2988	304	1	however	however	ADV
admet-2988	304	2	,	,	PUNCT
admet-2988	304	3	these	these	DET
admet-2988	304	4	approaches	approach	NOUN
admet-2988	304	5	also	also	ADV
admet-2988	304	6	pose	pose	VERB
admet-2988	304	7	challenges	challenge	NOUN
admet-2988	304	8	,	,	PUNCT
admet-2988	304	9	including	include	VERB
admet-2988	304	10	receptor	receptor	NOUN
admet-2988	304	11	saturation	saturation	NOUN
admet-2988	304	12	,	,	PUNCT
admet-2988	304	13	competition	competition	NOUN
admet-2988	304	14	with	with	ADP
admet-2988	304	15	endogenous	endogenous	ADJ
admet-2988	304	16	ligands	ligand	NOUN
admet-2988	304	17	,	,	PUNCT
admet-2988	304	18	and	and	CCONJ
admet-2988	304	19	variability	variability	NOUN
admet-2988	304	20	in	in	ADP
admet-2988	304	21	receptor	receptor	NOUN
admet-2988	304	22	expression	expression	NOUN
admet-2988	304	23	across	across	ADP
admet-2988	304	24	disease	disease	NOUN
admet-2988	304	25	states	state	NOUN
admet-2988	304	26	.	.	PUNCT
admet-2988	305	1	achieving	achieve	VERB
admet-2988	305	2	an	an	DET
admet-2988	305	3	optimal	optimal	ADJ
admet-2988	305	4	balance	balance	NOUN
admet-2988	305	5	between	between	ADP
admet-2988	305	6	targeting	target	VERB
admet-2988	305	7	specificity	specificity	NOUN
admet-2988	305	8	and	and	CCONJ
admet-2988	305	9	clinical	clinical	ADJ
admet-2988	305	10	applicability	applicability	NOUN
admet-2988	305	11	remains	remain	VERB
admet-2988	305	12	a	a	DET
admet-2988	305	13	critical	critical	ADJ
admet-2988	305	14	challenge	challenge	NOUN
admet-2988	305	15	.	.	PUNCT
admet-2988	306	1	despite	despite	SCONJ
admet-2988	306	2	the	the	DET
admet-2988	306	3	promise	promise	NOUN
admet-2988	306	4	of	of	ADP
admet-2988	306	5	these	these	DET
admet-2988	306	6	strategies	strategy	NOUN
admet-2988	306	7	,	,	PUNCT
admet-2988	306	8	most	most	ADV
admet-2988	306	9	remain	remain	VERB
admet-2988	306	10	at	at	ADP
admet-2988	306	11	the	the	DET
admet-2988	306	12	preclinical	preclinical	ADJ
admet-2988	306	13	or	or	CCONJ
admet-2988	306	14	laboratory	laboratory	NOUN
admet-2988	306	15	scale	scale	NOUN
admet-2988	306	16	,	,	PUNCT
admet-2988	306	17	highlighting	highlight	VERB
admet-2988	306	18	the	the	DET
admet-2988	306	19	need	need	NOUN
admet-2988	306	20	for	for	ADP
admet-2988	306	21	further	further	ADJ
admet-2988	306	22	research	research	NOUN
admet-2988	306	23	to	to	PART
admet-2988	306	24	bridge	bridge	VERB
admet-2988	306	25	the	the	DET
admet-2988	306	26	existing	exist	VERB
admet-2988	306	27	gap	gap	NOUN
admet-2988	306	28	and	and	CCONJ
admet-2988	306	29	facilitate	facilitate	VERB
admet-2988	306	30	their	their	PRON
admet-2988	306	31	translation	translation	NOUN
admet-2988	306	32	into	into	ADP
admet-2988	306	33	clinical	clinical	ADJ
admet-2988	306	34	practice	practice	NOUN
admet-2988	306	35	.	.	PUNCT
admet-2988	307	1	observations	observation	NOUN
admet-2988	307	2	on	on	ADP
admet-2988	307	3	bbb	bbb	PROPN
admet-2988	307	4	permeability	permeability	NOUN
admet-2988	307	5	models	model	NOUN
admet-2988	307	6	also	also	ADV
admet-2988	307	7	highlight	highlight	VERB
admet-2988	307	8	the	the	DET
admet-2988	307	9	need	need	NOUN
admet-2988	307	10	for	for	ADP
admet-2988	307	11	a	a	DET
admet-2988	307	12	paradigm	paradigm	NOUN
admet-2988	307	13	shift	shift	NOUN
admet-2988	307	14	in	in	ADP
admet-2988	307	15	preclinical	preclinical	ADJ
admet-2988	307	16	testing	testing	NOUN
admet-2988	307	17	.	.	PUNCT
admet-2988	308	1	traditional	traditional	ADJ
admet-2988	308	2	in	in	ADP
admet-2988	308	3	vitro	vitro	X
admet-2988	308	4	models	model	NOUN
admet-2988	308	5	provide	provide	VERB
admet-2988	308	6	valuable	valuable	ADJ
admet-2988	308	7	insights	insight	NOUN
admet-2988	308	8	,	,	PUNCT
admet-2988	308	9	but	but	CCONJ
admet-2988	308	10	often	often	ADV
admet-2988	308	11	lack	lack	VERB
admet-2988	308	12	the	the	DET
admet-2988	308	13	complexity	complexity	NOUN
admet-2988	308	14	of	of	ADP
admet-2988	308	15	the	the	DET
admet-2988	308	16	in	in	ADP
admet-2988	308	17	vivo	vivo	NOUN
admet-2988	308	18	environment	environment	NOUN
admet-2988	308	19	,	,	PUNCT
admet-2988	308	20	resulting	result	VERB
admet-2988	308	21	in	in	ADP
admet-2988	308	22	limited	limited	ADJ
admet-2988	308	23	correlation	correlation	NOUN
admet-2988	308	24	with	with	ADP
admet-2988	308	25	in	in	ADP
admet-2988	308	26	vivo	vivo	NOUN
admet-2988	308	27	results	result	NOUN
admet-2988	308	28	.	.	PUNCT
admet-2988	309	1	conversely	conversely	ADV
admet-2988	309	2	,	,	PUNCT
admet-2988	309	3	in	in	ADP
admet-2988	309	4	vivo	vivo	NOUN
admet-2988	309	5	models	model	NOUN
admet-2988	309	6	raise	raise	VERB
admet-2988	309	7	ethical	ethical	ADJ
admet-2988	309	8	concerns	concern	NOUN
admet-2988	309	9	and	and	CCONJ
admet-2988	309	10	may	may	AUX
admet-2988	309	11	fail	fail	VERB
admet-2988	309	12	to	to	PART
admet-2988	309	13	reflect	reflect	VERB
admet-2988	309	14	human	human	ADJ
admet-2988	309	15	physiology	physiology	NOUN
admet-2988	309	16	accurately	accurately	ADV
admet-2988	309	17	.	.	PUNCT
admet-2988	310	1	the	the	DET
admet-2988	310	2	emergence	emergence	NOUN
admet-2988	310	3	of	of	ADP
admet-2988	310	4	ooc	ooc	NOUN
admet-2988	310	5	platforms	platform	NOUN
admet-2988	310	6	offers	offer	VERB
admet-2988	310	7	a	a	DET
admet-2988	310	8	promising	promising	ADJ
admet-2988	310	9	middle	middle	ADJ
admet-2988	310	10	ground	ground	NOUN
admet-2988	310	11	,	,	PUNCT
admet-2988	310	12	enabling	enable	VERB
admet-2988	310	13	human	human	NOUN
admet-2988	310	14	-	-	PUNCT
admet-2988	310	15	relevant	relevant	ADJ
admet-2988	310	16	,	,	PUNCT
admet-2988	310	17	high	high	ADJ
admet-2988	310	18	-	-	PUNCT
admet-2988	310	19	throughput	throughput	NOUN
admet-2988	310	20	screening	screening	NOUN
admet-2988	310	21	of	of	ADP
admet-2988	310	22	nanoparticle	nanoparticle	NOUN
admet-2988	310	23	behaviour	behaviour	NOUN
admet-2988	310	24	under	under	ADP
admet-2988	310	25	physiologically	physiologically	ADV
admet-2988	310	26	relevant	relevant	ADJ
admet-2988	310	27	conditions	condition	NOUN
admet-2988	310	28	.	.	PUNCT
admet-2988	311	1	however	however	ADV
admet-2988	311	2	,	,	PUNCT
admet-2988	311	3	most	most	ADJ
admet-2988	311	4	ooc	ooc	NOUN
admet-2988	311	5	systems	system	NOUN
admet-2988	311	6	remain	remain	VERB
admet-2988	311	7	at	at	ADP
admet-2988	311	8	the	the	DET
admet-2988	311	9	proof	proof	NOUN
admet-2988	311	10	-	-	PUNCT
admet-2988	311	11	of	of	ADP
admet-2988	311	12	-	-	PUNCT
admet-2988	311	13	concept	concept	NOUN
admet-2988	311	14	stage	stage	NOUN
admet-2988	311	15	,	,	PUNCT
admet-2988	311	16	requiring	require	VERB
admet-2988	311	17	further	further	ADJ
admet-2988	311	18	validation	validation	NOUN
admet-2988	311	19	and	and	CCONJ
admet-2988	311	20	a	a	DET
admet-2988	311	21	robust	robust	ADJ
admet-2988	311	22	regulatory	regulatory	ADJ
admet-2988	311	23	framework	framework	NOUN
admet-2988	311	24	before	before	SCONJ
admet-2988	311	25	they	they	PRON
admet-2988	311	26	can	can	AUX
admet-2988	311	27	be	be	AUX
admet-2988	311	28	fully	fully	ADV
admet-2988	311	29	integrated	integrate	VERB
admet-2988	311	30	into	into	ADP
admet-2988	311	31	preclinical	preclinical	ADJ
admet-2988	311	32	pipelines	pipeline	NOUN
admet-2988	311	33	.	.	PUNCT
admet-2988	312	1	in	in	ADP
admet-2988	312	2	light	light	NOUN
admet-2988	312	3	of	of	ADP
admet-2988	312	4	these	these	DET
admet-2988	312	5	advancements	advancement	NOUN
admet-2988	312	6	and	and	CCONJ
admet-2988	312	7	ongoing	ongoing	ADJ
admet-2988	312	8	challenges	challenge	NOUN
admet-2988	312	9	,	,	PUNCT
admet-2988	312	10	the	the	DET
admet-2988	312	11	field	field	NOUN
admet-2988	312	12	of	of	ADP
admet-2988	312	13	bbb	bbb	PROPN
admet-2988	312	14	drug	drug	NOUN
admet-2988	312	15	delivery	delivery	NOUN
admet-2988	312	16	remains	remain	VERB
admet-2988	312	17	a	a	DET
admet-2988	312	18	critical	critical	ADJ
admet-2988	312	19	frontier	frontier	NOUN
admet-2988	312	20	in	in	ADP
admet-2988	312	21	biomedical	biomedical	ADJ
admet-2988	312	22	research	research	NOUN
admet-2988	312	23	.	.	PUNCT
admet-2988	313	1	the	the	DET
admet-2988	313	2	convergence	convergence	NOUN
admet-2988	313	3	of	of	ADP
admet-2988	313	4	nanotechnology	nanotechnology	NOUN
admet-2988	313	5	,	,	PUNCT
admet-2988	313	6	biomolecular	biomolecular	ADJ
admet-2988	313	7	engineering	engineering	NOUN
admet-2988	313	8	,	,	PUNCT
admet-2988	313	9	and	and	CCONJ
admet-2988	313	10	emerging	emerge	VERB
admet-2988	313	11	preclinical	preclinical	ADJ
admet-2988	313	12	models	model	NOUN
admet-2988	313	13	offers	offer	VERB
admet-2988	313	14	unprecedented	unprecedented	ADJ
admet-2988	313	15	opportunities	opportunity	NOUN
admet-2988	313	16	to	to	PART
admet-2988	313	17	enhance	enhance	VERB
admet-2988	313	18	cns	cns	NOUN
admet-2988	313	19	-	-	PUNCT
admet-2988	313	20	targeted	target	VERB
admet-2988	313	21	therapies	therapy	NOUN
admet-2988	313	22	.	.	PUNCT
admet-2988	314	1	however	however	ADV
admet-2988	314	2	,	,	PUNCT
admet-2988	314	3	significant	significant	ADJ
admet-2988	314	4	hurdles	hurdle	NOUN
admet-2988	314	5	still	still	ADV
admet-2988	314	6	need	need	VERB
admet-2988	314	7	to	to	PART
admet-2988	314	8	be	be	AUX
admet-2988	314	9	overcome	overcome	VERB
admet-2988	314	10	to	to	PART
admet-2988	314	11	enable	enable	VERB
admet-2988	314	12	the	the	DET
admet-2988	314	13	clinical	clinical	ADJ
admet-2988	314	14	translation	translation	NOUN
admet-2988	314	15	of	of	ADP
admet-2988	314	16	these	these	DET
admet-2988	314	17	strategies	strategy	NOUN
admet-2988	314	18	.	.	PUNCT
admet-2988	315	1	addressing	address	VERB
admet-2988	315	2	these	these	DET
admet-2988	315	3	challenges	challenge	NOUN
admet-2988	315	4	will	will	AUX
admet-2988	315	5	be	be	AUX
admet-2988	315	6	essential	essential	ADJ
admet-2988	315	7	for	for	ADP
admet-2988	315	8	advancing	advance	VERB
admet-2988	315	9	the	the	DET
admet-2988	315	10	treatment	treatment	NOUN
admet-2988	315	11	of	of	ADP
admet-2988	315	12	neurological	neurological	ADJ
admet-2988	315	13	and	and	CCONJ
admet-2988	315	14	psychiatric	psychiatric	ADJ
admet-2988	315	15	disorders	disorder	NOUN
admet-2988	315	16	,	,	PUNCT
admet-2988	315	17	as	as	ADV
admet-2988	315	18	well	well	ADV
admet-2988	315	19	as	as	ADP
admet-2988	315	20	brain	brain	NOUN
admet-2988	315	21	tumors	tumor	NOUN
admet-2988	315	22	,	,	PUNCT
admet-2988	315	23	thus	thus	ADV
admet-2988	315	24	paving	pave	VERB
admet-2988	315	25	the	the	DET
admet-2988	315	26	way	way	NOUN
admet-2988	315	27	for	for	ADP
admet-2988	315	28	more	more	ADV
admet-2988	315	29	effective	effective	ADJ
admet-2988	315	30	and	and	CCONJ
admet-2988	315	31	targeted	target	VERB
admet-2988	315	32	therapeutic	therapeutic	ADJ
admet-2988	315	33	interventions	intervention	NOUN
admet-2988	315	34	.	.	PUNCT
admet-2988	316	1	challenges	challenge	NOUN
admet-2988	316	2	and	and	CCONJ
admet-2988	316	3	future	future	ADJ
admet-2988	316	4	directions	direction	NOUN
admet-2988	316	5	despite	despite	SCONJ
admet-2988	316	6	decades	decade	NOUN
admet-2988	316	7	of	of	ADP
admet-2988	316	8	research	research	NOUN
admet-2988	316	9	,	,	PUNCT
admet-2988	316	10	significant	significant	ADJ
admet-2988	316	11	uncertainties	uncertainty	NOUN
admet-2988	316	12	remain	remain	VERB
admet-2988	316	13	regarding	regard	VERB
admet-2988	316	14	the	the	DET
admet-2988	316	15	roles	role	NOUN
admet-2988	316	16	of	of	ADP
admet-2988	316	17	specific	specific	ADJ
admet-2988	316	18	components	component	NOUN
admet-2988	316	19	of	of	ADP
admet-2988	316	20	the	the	DET
admet-2988	316	21	nvu	nvu	NOUN
admet-2988	316	22	.	.	PUNCT
admet-2988	317	1	a	a	DET
admet-2988	317	2	more	more	ADV
admet-2988	317	3	comprehensive	comprehensive	ADJ
admet-2988	317	4	understanding	understanding	NOUN
admet-2988	317	5	of	of	ADP
admet-2988	317	6	their	their	PRON
admet-2988	317	7	function	function	NOUN
admet-2988	317	8	could	could	AUX
admet-2988	317	9	unveil	unveil	VERB
admet-2988	317	10	previously	previously	ADV
admet-2988	317	11	unrecognized	unrecognize	VERB
admet-2988	317	12	pathways	pathway	NOUN
admet-2988	317	13	for	for	ADP
admet-2988	317	14	drug	drug	NOUN
admet-2988	317	15	transport	transport	NOUN
admet-2988	317	16	,	,	PUNCT
admet-2988	317	17	thereby	thereby	ADV
admet-2988	317	18	expanding	expand	VERB
admet-2988	317	19	the	the	DET
admet-2988	317	20	landscape	landscape	NOUN
admet-2988	317	21	of	of	ADP
admet-2988	317	22	bbb	bbb	PROPN
admet-2988	317	23	-	-	PUNCT
admet-2988	317	24	targeting	target	VERB
admet-2988	317	25	strategies	strategy	NOUN
admet-2988	317	26	.	.	PUNCT
admet-2988	318	1	key	key	ADJ
admet-2988	318	2	areas	area	NOUN
admet-2988	318	3	for	for	ADP
admet-2988	318	4	future	future	ADJ
admet-2988	318	5	investigation	investigation	NOUN
admet-2988	318	6	include	include	VERB
admet-2988	318	7	glial	glial	ADJ
admet-2988	318	8	cell	cell	NOUN
admet-2988	318	9	functions	function	NOUN
admet-2988	318	10	,	,	PUNCT
admet-2988	318	11	the	the	DET
admet-2988	318	12	molecular	molecular	ADJ
admet-2988	318	13	mechanisms	mechanism	NOUN
admet-2988	318	14	governing	govern	VERB
admet-2988	318	15	bbb	bbb	PROPN
admet-2988	318	16	integrity	integrity	NOUN
admet-2988	318	17	,	,	PUNCT
admet-2988	318	18	and	and	CCONJ
admet-2988	318	19	the	the	DET
admet-2988	318	20	dynamic	dynamic	ADJ
admet-2988	318	21	,	,	PUNCT
admet-2988	318	22	context	context	NOUN
admet-2988	318	23	-	-	PUNCT
admet-2988	318	24	dependent	dependent	ADJ
admet-2988	318	25	modulation	modulation	NOUN
admet-2988	318	26	of	of	ADP
admet-2988	318	27	its	its	PRON
admet-2988	318	28	transport	transport	NOUN
admet-2988	318	29	systems	system	NOUN
admet-2988	318	30	,	,	PUNCT
admet-2988	318	31	particularly	particularly	ADV
admet-2988	318	32	endocytic	endocytic	ADJ
admet-2988	318	33	pathways	pathway	NOUN
admet-2988	318	34	.	.	PUNCT
admet-2988	319	1	additionally	additionally	ADV
admet-2988	319	2	,	,	PUNCT
admet-2988	319	3	advancing	advance	VERB
admet-2988	319	4	pathological	pathological	ADJ
admet-2988	319	5	insights	insight	NOUN
admet-2988	319	6	into	into	ADP
admet-2988	319	7	neurological	neurological	ADJ
admet-2988	319	8	diseases	disease	NOUN
admet-2988	319	9	could	could	AUX
admet-2988	319	10	yield	yield	VERB
admet-2988	319	11	valuable	valuable	ADJ
admet-2988	319	12	clues	clue	NOUN
admet-2988	319	13	for	for	ADP
admet-2988	319	14	optimizing	optimize	VERB
admet-2988	319	15	therapeutic	therapeutic	ADJ
admet-2988	319	16	interventions	intervention	NOUN
admet-2988	319	17	.	.	PUNCT
admet-2988	320	1	in	in	ADP
admet-2988	320	2	this	this	DET
admet-2988	320	3	context	context	NOUN
admet-2988	320	4	,	,	PUNCT
admet-2988	320	5	personalized	personalized	ADJ
admet-2988	320	6	nanomedicine	nanomedicine	NOUN
admet-2988	320	7	represents	represent	VERB
admet-2988	320	8	a	a	DET
admet-2988	320	9	promising	promising	ADJ
admet-2988	320	10	avenue	avenue	NOUN
admet-2988	320	11	,	,	PUNCT
admet-2988	320	12	with	with	ADP
admet-2988	320	13	patient	patient	NOUN
admet-2988	320	14	-	-	PUNCT
admet-2988	320	15	specific	specific	ADJ
admet-2988	320	16	factors	factor	NOUN
admet-2988	320	17	offering	offer	VERB
admet-2988	320	18	the	the	DET
admet-2988	320	19	development	development	NOUN
admet-2988	320	20	of	of	ADP
admet-2988	320	21	precision	precision	NOUN
admet-2988	320	22	therapeutics	therapeutic	NOUN
admet-2988	320	23	tailored	tailor	VERB
admet-2988	320	24	to	to	ADP
admet-2988	320	25	individual	individual	ADJ
admet-2988	320	26	needs	need	NOUN
admet-2988	320	27	.	.	PUNCT
admet-2988	321	1	admet	admet	PROPN
admet-2988	321	2	&	&	CCONJ
admet-2988	321	3	dmpk	dmpk	PROPN
admet-2988	321	4	13(5	13(5	NUM
admet-2988	321	5	)	)	PUNCT
admet-2988	321	6	(	(	PUNCT
admet-2988	321	7	2025	2025	NUM
admet-2988	321	8	)	)	PUNCT
admet-2988	321	9	2988	2988	NUM
admet-2988	321	10	advancing	advance	VERB
admet-2988	321	11	through	through	ADP
admet-2988	321	12	the	the	DET
admet-2988	321	13	blood	blood	NOUN
admet-2988	321	14	-	-	PUNCT
admet-2988	321	15	brain	brain	NOUN
admet-2988	321	16	barrier	barrier	NOUN
admet-2988	321	17	doi	doi	NOUN
admet-2988	321	18	:	:	PUNCT
admet-2988	321	19	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	321	20	15	15	NUM
admet-2988	321	21	the	the	DET
admet-2988	321	22	diversity	diversity	NOUN
admet-2988	321	23	of	of	ADP
admet-2988	321	24	potential	potential	ADJ
admet-2988	321	25	approaches	approach	NOUN
admet-2988	321	26	for	for	ADP
admet-2988	321	27	cns	cns	NOUN
admet-2988	321	28	drug	drug	NOUN
admet-2988	321	29	delivery	delivery	NOUN
admet-2988	321	30	underscores	underscore	VERB
admet-2988	321	31	the	the	DET
admet-2988	321	32	growing	grow	VERB
admet-2988	321	33	need	need	NOUN
admet-2988	321	34	for	for	ADP
admet-2988	321	35	research	research	NOUN
admet-2988	321	36	to	to	PART
admet-2988	321	37	ensure	ensure	VERB
admet-2988	321	38	both	both	DET
admet-2988	321	39	safety	safety	NOUN
admet-2988	321	40	and	and	CCONJ
admet-2988	321	41	efficacy	efficacy	NOUN
admet-2988	321	42	.	.	PUNCT
admet-2988	322	1	each	each	DET
admet-2988	322	2	delivery	delivery	NOUN
admet-2988	322	3	strategy	strategy	NOUN
admet-2988	322	4	presents	present	VERB
admet-2988	322	5	distinct	distinct	ADJ
admet-2988	322	6	advantages	advantage	NOUN
admet-2988	322	7	and	and	CCONJ
admet-2988	322	8	limitations	limitation	NOUN
admet-2988	322	9	,	,	PUNCT
admet-2988	322	10	just	just	ADV
admet-2988	322	11	as	as	SCONJ
admet-2988	322	12	each	each	DET
admet-2988	322	13	neurological	neurological	ADJ
admet-2988	322	14	disorder	disorder	NOUN
admet-2988	322	15	is	be	AUX
admet-2988	322	16	characterized	characterize	VERB
admet-2988	322	17	by	by	ADP
admet-2988	322	18	a	a	DET
admet-2988	322	19	unique	unique	ADJ
admet-2988	322	20	pathophysiology	pathophysiology	NOUN
admet-2988	322	21	.	.	PUNCT
admet-2988	323	1	although	although	SCONJ
admet-2988	323	2	many	many	ADJ
admet-2988	323	3	of	of	ADP
admet-2988	323	4	these	these	DET
admet-2988	323	5	innovative	innovative	ADJ
admet-2988	323	6	strategies	strategy	NOUN
admet-2988	323	7	demonstrate	demonstrate	VERB
admet-2988	323	8	considerable	considerable	ADJ
admet-2988	323	9	promise	promise	NOUN
admet-2988	323	10	,	,	PUNCT
admet-2988	323	11	most	most	ADV
admet-2988	323	12	remain	remain	VERB
admet-2988	323	13	at	at	ADP
admet-2988	323	14	the	the	DET
admet-2988	323	15	preclinical	preclinical	ADJ
admet-2988	323	16	or	or	CCONJ
admet-2988	323	17	early	early	ADJ
admet-2988	323	18	investigational	investigational	ADJ
admet-2988	323	19	stages	stage	NOUN
admet-2988	323	20	and	and	CCONJ
admet-2988	323	21	have	have	VERB
admet-2988	323	22	yet	yet	ADV
admet-2988	323	23	to	to	PART
admet-2988	323	24	transition	transition	VERB
admet-2988	323	25	into	into	ADP
admet-2988	323	26	clinical	clinical	ADJ
admet-2988	323	27	application	application	NOUN
admet-2988	323	28	.	.	PUNCT
admet-2988	324	1	advancing	advance	VERB
admet-2988	324	2	in	in	ADP
admet-2988	324	3	this	this	DET
admet-2988	324	4	field	field	NOUN
admet-2988	324	5	requires	require	VERB
admet-2988	324	6	an	an	DET
admet-2988	324	7	integrated	integrate	VERB
admet-2988	324	8	,	,	PUNCT
admet-2988	324	9	multidisciplinary	multidisciplinary	ADJ
admet-2988	324	10	approach	approach	NOUN
admet-2988	324	11	—	—	PUNCT
admet-2988	324	12	leveraging	leverage	VERB
admet-2988	324	13	emerging	emerge	VERB
admet-2988	324	14	technologies	technology	NOUN
admet-2988	324	15	,	,	PUNCT
admet-2988	324	16	combining	combine	VERB
admet-2988	324	17	complementary	complementary	ADJ
admet-2988	324	18	strategies	strategy	NOUN
admet-2988	324	19	,	,	PUNCT
admet-2988	324	20	refining	refining	NOUN
admet-2988	324	21	delivery	delivery	NOUN
admet-2988	324	22	systems	system	NOUN
admet-2988	324	23	,	,	PUNCT
admet-2988	324	24	and	and	CCONJ
admet-2988	324	25	aligning	align	VERB
admet-2988	324	26	interventions	intervention	NOUN
admet-2988	324	27	with	with	ADP
admet-2988	324	28	the	the	DET
admet-2988	324	29	molecular	molecular	ADJ
admet-2988	324	30	characteristics	characteristic	NOUN
admet-2988	324	31	of	of	ADP
admet-2988	324	32	specific	specific	ADJ
admet-2988	324	33	diseases	disease	NOUN
admet-2988	324	34	—	—	PUNCT
admet-2988	324	35	to	to	PART
admet-2988	324	36	develop	develop	VERB
admet-2988	324	37	effective	effective	ADJ
admet-2988	324	38	,	,	PUNCT
admet-2988	324	39	scalable	scalable	ADJ
admet-2988	324	40	,	,	PUNCT
admet-2988	324	41	and	and	CCONJ
admet-2988	324	42	patient	patient	NOUN
admet-2988	324	43	-	-	PUNCT
admet-2988	324	44	centered	center	VERB
admet-2988	324	45	therapeutics	therapeutic	NOUN
admet-2988	324	46	for	for	ADP
admet-2988	324	47	cns	cns	NOUN
admet-2988	324	48	disorders	disorder	NOUN
admet-2988	324	49	.	.	PUNCT
admet-2988	325	1	furthermore	furthermore	ADV
admet-2988	325	2	,	,	PUNCT
admet-2988	325	3	the	the	DET
admet-2988	325	4	development	development	NOUN
admet-2988	325	5	of	of	ADP
admet-2988	325	6	robust	robust	ADJ
admet-2988	325	7	evaluation	evaluation	NOUN
admet-2988	325	8	methods	method	NOUN
admet-2988	325	9	to	to	PART
admet-2988	325	10	assess	assess	VERB
admet-2988	325	11	the	the	DET
admet-2988	325	12	effectiveness	effectiveness	NOUN
admet-2988	325	13	of	of	ADP
admet-2988	325	14	these	these	DET
admet-2988	325	15	systems	system	NOUN
admet-2988	325	16	in	in	ADP
admet-2988	325	17	crossing	cross	VERB
admet-2988	325	18	the	the	DET
admet-2988	325	19	bbb	bbb	PROPN
admet-2988	325	20	is	be	AUX
admet-2988	325	21	crucial	crucial	ADJ
admet-2988	325	22	.	.	PUNCT
admet-2988	326	1	ethically	ethically	ADV
admet-2988	326	2	sound	sound	VERB
admet-2988	326	3	and	and	CCONJ
admet-2988	326	4	reproducible	reproducible	ADJ
admet-2988	326	5	assessment	assessment	NOUN
admet-2988	326	6	strategies	strategy	NOUN
admet-2988	326	7	are	be	AUX
admet-2988	326	8	essential	essential	ADJ
admet-2988	326	9	for	for	ADP
admet-2988	326	10	validating	validate	VERB
admet-2988	326	11	and	and	CCONJ
admet-2988	326	12	optimizing	optimize	VERB
admet-2988	326	13	nanotechnology	nanotechnology	NOUN
admet-2988	326	14	-	-	PUNCT
admet-2988	326	15	based	base	VERB
admet-2988	326	16	approaches	approach	NOUN
admet-2988	326	17	.	.	PUNCT
admet-2988	327	1	such	such	ADJ
admet-2988	327	2	methodologies	methodology	NOUN
admet-2988	327	3	will	will	AUX
admet-2988	327	4	not	not	PART
admet-2988	327	5	only	only	ADV
admet-2988	327	6	ensure	ensure	VERB
admet-2988	327	7	that	that	SCONJ
admet-2988	327	8	scientific	scientific	ADJ
admet-2988	327	9	advancements	advancement	NOUN
admet-2988	327	10	translate	translate	VERB
admet-2988	327	11	into	into	ADP
admet-2988	327	12	clinically	clinically	ADV
admet-2988	327	13	relevant	relevant	ADJ
admet-2988	327	14	and	and	CCONJ
admet-2988	327	15	reproducible	reproducible	VERB
admet-2988	327	16	outcomes	outcome	NOUN
admet-2988	327	17	but	but	CCONJ
admet-2988	327	18	also	also	ADV
admet-2988	327	19	help	help	VERB
admet-2988	327	20	minimize	minimize	VERB
admet-2988	327	21	bottlenecks	bottleneck	NOUN
admet-2988	327	22	in	in	ADP
admet-2988	327	23	the	the	DET
admet-2988	327	24	clinical	clinical	ADJ
admet-2988	327	25	translation	translation	NOUN
admet-2988	327	26	process	process	NOUN
admet-2988	327	27	.	.	PUNCT
admet-2988	328	1	a	a	DET
admet-2988	328	2	major	major	ADJ
admet-2988	328	3	opportunity	opportunity	NOUN
admet-2988	328	4	for	for	ADP
admet-2988	328	5	advancement	advancement	NOUN
admet-2988	328	6	lies	lie	VERB
admet-2988	328	7	in	in	ADP
admet-2988	328	8	the	the	DET
admet-2988	328	9	inherently	inherently	ADV
admet-2988	328	10	multidisciplinary	multidisciplinary	ADJ
admet-2988	328	11	nature	nature	NOUN
admet-2988	328	12	of	of	ADP
admet-2988	328	13	this	this	DET
admet-2988	328	14	field	field	NOUN
admet-2988	328	15	.	.	PUNCT
admet-2988	329	1	crossdisciplinary	crossdisciplinary	ADJ
admet-2988	329	2	collaboration	collaboration	NOUN
admet-2988	329	3	holds	hold	VERB
admet-2988	329	4	the	the	DET
admet-2988	329	5	potential	potential	NOUN
admet-2988	329	6	to	to	PART
admet-2988	329	7	synthesize	synthesize	VERB
admet-2988	329	8	diverse	diverse	ADJ
admet-2988	329	9	findings	finding	NOUN
admet-2988	329	10	and	and	CCONJ
admet-2988	329	11	strengthen	strengthen	VERB
admet-2988	329	12	future	future	ADJ
admet-2988	329	13	directions	direction	NOUN
admet-2988	329	14	.	.	PUNCT
admet-2988	330	1	while	while	SCONJ
admet-2988	330	2	research	research	NOUN
admet-2988	330	3	gaps	gap	NOUN
admet-2988	330	4	are	be	AUX
admet-2988	330	5	closing	close	VERB
admet-2988	330	6	in	in	ADP
admet-2988	330	7	the	the	DET
admet-2988	330	8	body	body	NOUN
admet-2988	330	9	of	of	ADP
admet-2988	330	10	knowledge	knowledge	NOUN
admet-2988	330	11	,	,	PUNCT
admet-2988	330	12	new	new	ADJ
admet-2988	330	13	therapeutic	therapeutic	ADJ
admet-2988	330	14	opportunities	opportunity	NOUN
admet-2988	330	15	are	be	AUX
admet-2988	330	16	emerging	emerge	VERB
admet-2988	330	17	,	,	PUNCT
admet-2988	330	18	creating	create	VERB
admet-2988	330	19	pathways	pathway	NOUN
admet-2988	330	20	for	for	ADP
admet-2988	330	21	innovation	innovation	NOUN
admet-2988	330	22	in	in	ADP
admet-2988	330	23	cns	cns	NOUN
admet-2988	330	24	therapeutics	therapeutic	NOUN
admet-2988	330	25	.	.	PUNCT
admet-2988	331	1	conclusions	conclusion	NOUN
admet-2988	331	2	research	research	NOUN
admet-2988	331	3	on	on	ADP
admet-2988	331	4	the	the	DET
admet-2988	331	5	bbb	bbb	PROPN
admet-2988	331	6	has	have	AUX
admet-2988	331	7	advanced	advance	VERB
admet-2988	331	8	significantly	significantly	ADV
admet-2988	331	9	,	,	PUNCT
admet-2988	331	10	laying	lay	VERB
admet-2988	331	11	the	the	DET
admet-2988	331	12	foundation	foundation	NOUN
admet-2988	331	13	for	for	ADP
admet-2988	331	14	new	new	ADJ
admet-2988	331	15	therapeutic	therapeutic	ADJ
admet-2988	331	16	strategies	strategy	NOUN
admet-2988	331	17	.	.	PUNCT
admet-2988	332	1	in	in	ADP
admet-2988	332	2	this	this	DET
admet-2988	332	3	context	context	NOUN
admet-2988	332	4	,	,	PUNCT
admet-2988	332	5	nanotechnology	nanotechnology	NOUN
admet-2988	332	6	emerges	emerge	VERB
admet-2988	332	7	as	as	ADP
admet-2988	332	8	an	an	DET
admet-2988	332	9	innovative	innovative	ADJ
admet-2988	332	10	tool	tool	NOUN
admet-2988	332	11	to	to	PART
admet-2988	332	12	enhance	enhance	VERB
admet-2988	332	13	drug	drug	NOUN
admet-2988	332	14	delivery	delivery	NOUN
admet-2988	332	15	to	to	ADP
admet-2988	332	16	the	the	DET
admet-2988	332	17	cns	cns	NOUN
admet-2988	332	18	.	.	PUNCT
admet-2988	333	1	however	however	ADV
admet-2988	333	2	,	,	PUNCT
admet-2988	333	3	despite	despite	SCONJ
admet-2988	333	4	notable	notable	ADJ
admet-2988	333	5	progress	progress	NOUN
admet-2988	333	6	,	,	PUNCT
admet-2988	333	7	key	key	ADJ
admet-2988	333	8	challenges	challenge	NOUN
admet-2988	333	9	remain	remain	VERB
admet-2988	333	10	.	.	PUNCT
admet-2988	334	1	a	a	DET
admet-2988	334	2	deeper	deep	ADJ
admet-2988	334	3	understanding	understanding	NOUN
admet-2988	334	4	of	of	ADP
admet-2988	334	5	bbb	bbb	PROPN
admet-2988	334	6	physiology	physiology	NOUN
admet-2988	334	7	and	and	CCONJ
admet-2988	334	8	its	its	PRON
admet-2988	334	9	diseaserelated	diseaserelate	VERB
admet-2988	334	10	changes	change	NOUN
admet-2988	334	11	,	,	PUNCT
admet-2988	334	12	the	the	DET
admet-2988	334	13	refinement	refinement	NOUN
admet-2988	334	14	of	of	ADP
admet-2988	334	15	transport	transport	NOUN
admet-2988	334	16	-	-	PUNCT
admet-2988	334	17	targeting	target	VERB
admet-2988	334	18	mechanisms	mechanism	NOUN
admet-2988	334	19	,	,	PUNCT
admet-2988	334	20	the	the	DET
admet-2988	334	21	development	development	NOUN
admet-2988	334	22	of	of	ADP
admet-2988	334	23	physiologically	physiologically	ADV
admet-2988	334	24	relevant	relevant	ADJ
admet-2988	334	25	evaluation	evaluation	NOUN
admet-2988	334	26	models	model	NOUN
admet-2988	334	27	,	,	PUNCT
admet-2988	334	28	and	and	CCONJ
admet-2988	334	29	the	the	DET
admet-2988	334	30	establishment	establishment	NOUN
admet-2988	334	31	of	of	ADP
admet-2988	334	32	clear	clear	ADJ
admet-2988	334	33	regulatory	regulatory	ADJ
admet-2988	334	34	pathways	pathway	NOUN
admet-2988	334	35	are	be	AUX
admet-2988	334	36	all	all	ADV
admet-2988	334	37	essential	essential	ADJ
admet-2988	334	38	for	for	ADP
admet-2988	334	39	achieving	achieve	VERB
admet-2988	334	40	clinically	clinically	ADV
admet-2988	334	41	viable	viable	ADJ
admet-2988	334	42	solutions	solution	NOUN
admet-2988	334	43	.	.	PUNCT
admet-2988	335	1	this	this	DET
admet-2988	335	2	review	review	NOUN
admet-2988	335	3	provides	provide	VERB
admet-2988	335	4	a	a	DET
admet-2988	335	5	comprehensive	comprehensive	ADJ
admet-2988	335	6	overview	overview	NOUN
admet-2988	335	7	of	of	ADP
admet-2988	335	8	the	the	DET
admet-2988	335	9	foundational	foundational	ADJ
admet-2988	335	10	elements	element	NOUN
admet-2988	335	11	that	that	PRON
admet-2988	335	12	can	can	AUX
admet-2988	335	13	shape	shape	VERB
admet-2988	335	14	strategies	strategy	NOUN
admet-2988	335	15	for	for	ADP
admet-2988	335	16	overcoming	overcome	VERB
admet-2988	335	17	the	the	DET
admet-2988	335	18	bbb	bbb	NOUN
admet-2988	335	19	.	.	PUNCT
admet-2988	336	1	by	by	ADP
admet-2988	336	2	integrating	integrate	VERB
admet-2988	336	3	insights	insight	NOUN
admet-2988	336	4	from	from	ADP
admet-2988	336	5	lipid	lipid	NOUN
admet-2988	336	6	-	-	PUNCT
admet-2988	336	7	based	base	VERB
admet-2988	336	8	nanotechnology	nanotechnology	NOUN
admet-2988	336	9	,	,	PUNCT
admet-2988	336	10	functionalization	functionalization	NOUN
admet-2988	336	11	techniques	technique	NOUN
admet-2988	336	12	,	,	PUNCT
admet-2988	336	13	and	and	CCONJ
admet-2988	336	14	permeability	permeability	NOUN
admet-2988	336	15	models	model	NOUN
admet-2988	336	16	,	,	PUNCT
admet-2988	336	17	it	it	PRON
admet-2988	336	18	identifies	identify	VERB
admet-2988	336	19	critical	critical	ADJ
admet-2988	336	20	research	research	NOUN
admet-2988	336	21	gaps	gap	NOUN
admet-2988	336	22	and	and	CCONJ
admet-2988	336	23	opportunities	opportunity	NOUN
admet-2988	336	24	.	.	PUNCT
admet-2988	337	1	addressing	address	VERB
admet-2988	337	2	these	these	DET
admet-2988	337	3	challenges	challenge	NOUN
admet-2988	337	4	through	through	ADP
admet-2988	337	5	interdisciplinary	interdisciplinary	ADJ
admet-2988	337	6	collaboration	collaboration	NOUN
admet-2988	337	7	will	will	AUX
admet-2988	337	8	be	be	AUX
admet-2988	337	9	essential	essential	ADJ
admet-2988	337	10	for	for	ADP
admet-2988	337	11	translating	translate	VERB
admet-2988	337	12	promising	promise	VERB
admet-2988	337	13	nanomedicine	nanomedicine	NOUN
admet-2988	337	14	-	-	PUNCT
admet-2988	337	15	based	base	VERB
admet-2988	337	16	cns	cns	NOUN
admet-2988	337	17	therapies	therapy	NOUN
admet-2988	337	18	from	from	ADP
admet-2988	337	19	the	the	DET
admet-2988	337	20	bench	bench	NOUN
admet-2988	337	21	to	to	ADP
admet-2988	337	22	the	the	DET
admet-2988	337	23	bedside	bedside	NOUN
admet-2988	337	24	.	.	PUNCT
admet-2988	338	1	moving	move	VERB
admet-2988	338	2	forward	forward	ADV
admet-2988	338	3	,	,	PUNCT
admet-2988	338	4	the	the	DET
admet-2988	338	5	integration	integration	NOUN
admet-2988	338	6	of	of	ADP
admet-2988	338	7	fundamental	fundamental	ADJ
admet-2988	338	8	research	research	NOUN
admet-2988	338	9	,	,	PUNCT
admet-2988	338	10	applied	apply	VERB
admet-2988	338	11	nanomedicine	nanomedicine	NOUN
admet-2988	338	12	,	,	PUNCT
admet-2988	338	13	and	and	CCONJ
admet-2988	338	14	regulatory	regulatory	ADJ
admet-2988	338	15	science	science	NOUN
admet-2988	338	16	will	will	AUX
admet-2988	338	17	be	be	AUX
admet-2988	338	18	crucial	crucial	ADJ
admet-2988	338	19	—	—	PUNCT
admet-2988	338	20	not	not	PART
admet-2988	338	21	only	only	ADV
admet-2988	338	22	to	to	ADP
admet-2988	338	23	unlocking	unlock	VERB
admet-2988	338	24	the	the	DET
admet-2988	338	25	full	full	ADJ
admet-2988	338	26	potential	potential	NOUN
admet-2988	338	27	of	of	ADP
admet-2988	338	28	cns	cns	NOUN
admet-2988	338	29	-	-	PUNCT
admet-2988	338	30	targeted	target	VERB
admet-2988	338	31	therapies	therapy	NOUN
admet-2988	338	32	but	but	CCONJ
admet-2988	338	33	also	also	ADV
admet-2988	338	34	for	for	ADP
admet-2988	338	35	opening	open	VERB
admet-2988	338	36	new	new	ADJ
admet-2988	338	37	pathways	pathway	NOUN
admet-2988	338	38	across	across	ADP
admet-2988	338	39	the	the	DET
admet-2988	338	40	bbb	bbb	NOUN
admet-2988	338	41	for	for	ADP
admet-2988	338	42	the	the	DET
admet-2988	338	43	treatment	treatment	NOUN
admet-2988	338	44	of	of	ADP
admet-2988	338	45	neurological	neurological	ADJ
admet-2988	338	46	diseases	disease	NOUN
admet-2988	338	47	,	,	PUNCT
admet-2988	338	48	psychiatric	psychiatric	ADJ
admet-2988	338	49	disorders	disorder	NOUN
admet-2988	338	50	,	,	PUNCT
admet-2988	338	51	and	and	CCONJ
admet-2988	338	52	brain	brain	NOUN
admet-2988	338	53	tumours	tumour	NOUN
admet-2988	338	54	.	.	PUNCT
admet-2988	339	1	abbreviations	abbreviation	NOUN
admet-2988	339	2	bbb	bbb	PROPN
admet-2988	339	3	blood	blood	NOUN
admet-2988	339	4	-	-	PUNCT
admet-2988	339	5	brain	brain	NOUN
admet-2988	339	6	barrier	barrier	NOUN
admet-2988	339	7	bcrp	bcrp	PROPN
admet-2988	339	8	breast	breast	NOUN
admet-2988	339	9	cancer	cancer	NOUN
admet-2988	339	10	resistance	resistance	NOUN
admet-2988	339	11	protein	protein	NOUN
admet-2988	339	12	bl	bl	AUX
admet-2988	339	13	basal	basal	VERB
admet-2988	339	14	lamina	lamina	ADJ
admet-2988	339	15	cns	cns	PROPN
admet-2988	339	16	central	central	ADJ
admet-2988	339	17	nervous	nervous	ADJ
admet-2988	339	18	system	system	NOUN
admet-2988	339	19	ecs	ecs	NOUN
admet-2988	339	20	endothelial	endothelial	NOUN
admet-2988	339	21	cells	cell	NOUN
admet-2988	339	22	ipscs	ipsc	NOUN
admet-2988	339	23	induced	induce	VERB
admet-2988	339	24	pluripotent	pluripotent	ADJ
admet-2988	339	25	stem	stem	NOUN
admet-2988	339	26	cells	cell	NOUN
admet-2988	339	27	lnps	lnps	PROPN
admet-2988	339	28	lipid	lipid	NOUN
admet-2988	339	29	nanoparticles	nanoparticle	VERB
admet-2988	339	30	lrp1	lrp1	VERB
admet-2988	339	31	low	low	ADJ
admet-2988	339	32	-	-	PUNCT
admet-2988	339	33	density	density	NOUN
admet-2988	339	34	lipoprotein	lipoprotein	ADJ
admet-2988	339	35	receptor	receptor	NOUN
admet-2988	339	36	-	-	PUNCT
admet-2988	339	37	related	relate	VERB
admet-2988	339	38	protein	protein	NOUN
admet-2988	339	39	1	1	NUM
admet-2988	339	40	nvu	nvu	NOUN
admet-2988	339	41	neurovascular	neurovascular	ADJ
admet-2988	339	42	unit	unit	NOUN
admet-2988	339	43	ooc	ooc	NOUN
admet-2988	339	44	organ	organ	NOUN
admet-2988	339	45	-	-	PUNCT
admet-2988	339	46	on	on	ADP
admet-2988	339	47	-	-	PUNCT
admet-2988	339	48	a	a	DET
admet-2988	339	49	-	-	PUNCT
admet-2988	339	50	chip	chip	NOUN
admet-2988	339	51	p	p	NOUN
admet-2988	339	52	-	-	PUNCT
admet-2988	339	53	gp	gp	NOUN
admet-2988	339	54	p	p	NOUN
admet-2988	339	55	-	-	PUNCT
admet-2988	339	56	glycoprotein	glycoprotein	NOUN
admet-2988	339	57	teer	teer	NOUN
admet-2988	339	58	transendothelial	transendothelial	PROPN
admet-2988	339	59	electric	electric	ADJ
admet-2988	339	60	resistance	resistance	NOUN
admet-2988	339	61	rvg	rvg	PROPN
admet-2988	339	62	rabies	rabie	NOUN
admet-2988	339	63	virus	virus	NOUN
admet-2988	339	64	glycoprotein	glycoprotein	NOUN
admet-2988	339	65	tj	tj	X
admet-2988	339	66	tight	tight	ADJ
admet-2988	339	67	junctions	junction	NOUN
admet-2988	339	68	γ	γ	PROPN
admet-2988	339	69	-	-	PUNCT
admet-2988	339	70	gt	gt	NOUN
admet-2988	339	71	γ	γ	NOUN
admet-2988	339	72	-	-	ADJ
admet-2988	339	73	glutamyl	glutamyl	VERB
admet-2988	339	74	transpeptidase	transpeptidase	NOUN
admet-2988	339	75	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	VERB
admet-2988	339	76	r.	r.	PROPN
admet-2988	339	77	vargas	vargas	PROPN
admet-2988	339	78	et	et	PROPN
admet-2988	339	79	al	al	PROPN
admet-2988	339	80	.	.	PROPN
admet-2988	339	81	admet	admet	PROPN
admet-2988	339	82	&	&	CCONJ
admet-2988	339	83	dmpk	dmpk	PROPN
admet-2988	339	84	13(5	13(5	NUM
admet-2988	339	85	)	)	PUNCT
admet-2988	339	86	(	(	PUNCT
admet-2988	339	87	2025	2025	NUM
admet-2988	339	88	)	)	PUNCT
admet-2988	339	89	2988	2988	NUM
admet-2988	339	90	16	16	NUM
admet-2988	339	91	acknowledgements	acknowledgement	NOUN
admet-2988	339	92	:	:	PUNCT
admet-2988	339	93	this	this	DET
admet-2988	339	94	work	work	NOUN
admet-2988	339	95	was	be	AUX
admet-2988	339	96	possible	possible	ADJ
admet-2988	339	97	thanks	thank	NOUN
admet-2988	339	98	to	to	ADP
admet-2988	339	99	the	the	DET
admet-2988	339	100	grant	grant	NOUN
admet-2988	339	101	of	of	ADP
admet-2988	339	102	the	the	DET
admet-2988	339	103	university	university	PROPN
admet-2988	339	104	of	of	ADP
admet-2988	339	105	costa	costa	PROPN
admet-2988	339	106	rica	rica	PROPN
admet-2988	339	107	(	(	PUNCT
admet-2988	339	108	oaice-642019	oaice-642019	ADJ
admet-2988	339	109	and	and	CCONJ
admet-2988	339	110	research	research	NOUN
admet-2988	339	111	project	project	NOUN
admet-2988	339	112	817	817	NUM
admet-2988	339	113	-	-	PUNCT
admet-2988	339	114	c5	c5	PROPN
admet-2988	339	115	-	-	PUNCT
admet-2988	339	116	253	253	NUM
admet-2988	339	117	)	)	PUNCT
admet-2988	339	118	to	to	ADP
admet-2988	339	119	rv	rv	PRON
admet-2988	339	120	;	;	PUNCT
admet-2988	339	121	to	to	ADP
admet-2988	339	122	the	the	DET
admet-2988	339	123	grant	grant	NOUN
admet-2988	339	124	from	from	ADP
admet-2988	339	125	the	the	DET
admet-2988	339	126	departament	departament	NOUN
admet-2988	339	127	de	de	X
admet-2988	339	128	recerca	recerca	PROPN
admet-2988	339	129	i	i	PRON
admet-2988	339	130	universitats	universitat	VERB
admet-2988	339	131	,	,	PUNCT
admet-2988	339	132	generalitat	generalitat	PROPN
admet-2988	339	133	de	de	PROPN
admet-2988	339	134	catalunya	catalunya	PROPN
admet-2988	339	135	(	(	PUNCT
admet-2988	339	136	agaur	agaur	NOUN
admet-2988	339	137	2021	2021	NUM
admet-2988	339	138	sgr	sgr	PROPN
admet-2988	339	139	01068	01068	NUM
admet-2988	339	140	)	)	PUNCT
admet-2988	339	141	to	to	ADP
admet-2988	339	142	eg	eg	NOUN
admet-2988	339	143	-	-	PUNCT
admet-2988	339	144	m	m	NOUN
admet-2988	339	145	;	;	PUNCT
admet-2988	339	146	and	and	CCONJ
admet-2988	339	147	by	by	ADP
admet-2988	339	148	the	the	DET
admet-2988	339	149	spanish	spanish	PROPN
admet-2988	339	150	ministry	ministry	PROPN
admet-2988	339	151	of	of	ADP
admet-2988	339	152	science	science	NOUN
admet-2988	339	153	and	and	CCONJ
admet-2988	339	154	innovation	innovation	NOUN
admet-2988	339	155	(	(	PUNCT
admet-2988	339	156	pid2020	pid2020	NOUN
admet-2988	339	157	-	-	PUNCT
admet-2988	339	158	118859gb	118859gb	ADJ
admet-2988	339	159	-	-	PUNCT
admet-2988	339	160	i00	i00	NOUN
admet-2988	339	161	)	)	PUNCT
admet-2988	339	162	to	to	ADP
admet-2988	339	163	cs	cs	PROPN
admet-2988	339	164	.	.	PROPN
admet-2988	339	165	conflict	conflict	NOUN
admet-2988	339	166	of	of	ADP
admet-2988	339	167	interest	interest	NOUN
admet-2988	339	168	:	:	PUNCT
admet-2988	339	169	the	the	DET
admet-2988	339	170	authors	author	NOUN
admet-2988	339	171	have	have	VERB
admet-2988	339	172	no	no	DET
admet-2988	339	173	conflicts	conflict	NOUN
admet-2988	339	174	of	of	ADP
admet-2988	339	175	interest	interest	NOUN
admet-2988	339	176	to	to	PART
admet-2988	339	177	declare	declare	VERB
admet-2988	339	178	references	reference	NOUN
admet-2988	339	179	[	[	X
admet-2988	339	180	1	1	NUM
admet-2988	339	181	]	]	X
admet-2988	339	182	j.e	j.e	PROPN
admet-2988	339	183	.	.	PROPN
admet-2988	339	184	niven	niven	PROPN
admet-2988	339	185	,	,	PUNCT
admet-2988	339	186	l.	l.	PROPN
admet-2988	339	187	chittka	chittka	PROPN
admet-2988	339	188	.	.	PUNCT
admet-2988	340	1	current	current	ADJ
admet-2988	340	2	biology	biology	NOUN
admet-2988	340	3	evolving	evolve	VERB
admet-2988	340	4	understanding	understanding	NOUN
admet-2988	340	5	of	of	ADP
admet-2988	340	6	nervous	nervous	ADJ
admet-2988	340	7	system	system	NOUN
admet-2988	340	8	evolution	evolution	NOUN
admet-2988	340	9	.	.	PUNCT
admet-2988	341	1	current	current	ADJ
admet-2988	341	2	biology	biology	NOUN
admet-2988	341	3	26	26	NUM
admet-2988	341	4	(	(	PUNCT
admet-2988	341	5	2016	2016	NUM
admet-2988	341	6	)	)	PUNCT
admet-2988	341	7	r937	r937	PROPN
admet-2988	341	8	-	-	SYM
admet-2988	341	9	r941	r941	PROPN
admet-2988	341	10	.	.	PUNCT
admet-2988	342	1	https://doi.org/10.1016/j.cub.2016.09.003	https://doi.org/10.1016/j.cub.2016.09.003	NOUN
admet-2988	342	2	[	[	X
admet-2988	342	3	2	2	NUM
admet-2988	342	4	]	]	PUNCT
admet-2988	342	5	a.	a.	NOUN
admet-2988	342	6	verkhratsky	verkhratsky	NOUN
admet-2988	342	7	,	,	PUNCT
admet-2988	342	8	m.	m.	NOUN
admet-2988	342	9	nedergaard	nedergaard	NOUN
admet-2988	342	10	.	.	PUNCT
admet-2988	343	1	the	the	DET
admet-2988	343	2	homeostatic	homeostatic	ADJ
admet-2988	343	3	astroglia	astroglia	NOUN
admet-2988	343	4	emerges	emerge	VERB
admet-2988	343	5	from	from	ADP
admet-2988	343	6	evolutionary	evolutionary	ADJ
admet-2988	343	7	specialization	specialization	NOUN
admet-2988	343	8	of	of	ADP
admet-2988	343	9	neural	neural	ADJ
admet-2988	343	10	cells	cell	NOUN
admet-2988	343	11	.	.	PUNCT
admet-2988	344	1	philosophical	philosophical	ADJ
admet-2988	344	2	transactions	transaction	NOUN
admet-2988	344	3	of	of	ADP
admet-2988	344	4	the	the	DET
admet-2988	344	5	royal	royal	ADJ
admet-2988	344	6	society	society	NOUN
admet-2988	344	7	b	b	NOUN
admet-2988	344	8	:	:	PUNCT
admet-2988	344	9	biological	biological	ADJ
admet-2988	344	10	sciences	science	NOUN
admet-2988	344	11	371	371	NUM
admet-2988	344	12	(	(	PUNCT
admet-2988	344	13	2015	2015	NUM
admet-2988	344	14	)	)	PUNCT
admet-2988	344	15	0428	0428	NUM
admet-2988	344	16	.	.	PUNCT
admet-2988	345	1	https://doi.org/10.1098/rstb.2015.0428	https://doi.org/10.1098/rstb.2015.0428	NOUN
admet-2988	345	2	[	[	SYM
admet-2988	345	3	3	3	NUM
admet-2988	345	4	]	]	PUNCT
admet-2988	345	5	a.	a.	NOUN
admet-2988	345	6	pivoriūnas	pivoriūnas	PROPN
admet-2988	345	7	,	,	PUNCT
admet-2988	345	8	a.	a.	NOUN
admet-2988	345	9	verkhratsky	verkhratsky	NOUN
admet-2988	345	10	.	.	PUNCT
admet-2988	346	1	astrocyte	astrocyte	ADJ
admet-2988	346	2	-	-	PUNCT
admet-2988	346	3	endotheliocyte	endotheliocyte	NOUN
admet-2988	346	4	axis	axis	NOUN
admet-2988	346	5	in	in	ADP
admet-2988	346	6	the	the	DET
admet-2988	346	7	regulation	regulation	NOUN
admet-2988	346	8	of	of	ADP
admet-2988	346	9	the	the	DET
admet-2988	346	10	blood	blood	NOUN
admet-2988	346	11	-	-	PUNCT
admet-2988	346	12	brain	brain	NOUN
admet-2988	346	13	barrier	barrier	NOUN
admet-2988	346	14	.	.	PUNCT
admet-2988	347	1	neurochemical	neurochemical	ADJ
admet-2988	347	2	research	research	NOUN
admet-2988	347	3	46	46	NUM
admet-2988	347	4	(	(	PUNCT
admet-2988	347	5	2021	2021	NUM
admet-2988	347	6	)	)	PUNCT
admet-2988	347	7	2538	2538	NUM
admet-2988	347	8	-	-	SYM
admet-2988	347	9	2550	2550	NUM
admet-2988	347	10	.	.	PUNCT
admet-2988	348	1	https://doi.org/10.1007/s11064-021-03338-6	https://doi.org/10.1007/s11064-021-03338-6	NUM
admet-2988	349	1	[	[	X
admet-2988	349	2	4	4	NUM
admet-2988	349	3	]	]	X
admet-2988	349	4	a.d	a.d	PROPN
admet-2988	349	5	.	.	PROPN
admet-2988	349	6	dunton	dunton	PROPN
admet-2988	349	7	,	,	PUNCT
admet-2988	349	8	t.göpel	t.göpel	PROPN
admet-2988	349	9	,	,	PUNCT
admet-2988	349	10	d.h	d.h	PROPN
admet-2988	349	11	.	.	PROPN
admet-2988	349	12	ho	ho	PROPN
admet-2988	349	13	,	,	PUNCT
admet-2988	349	14	w.	w.	PROPN
admet-2988	349	15	burggren	burggren	PROPN
admet-2988	349	16	.	.	PUNCT
admet-2988	350	1	form	form	NOUN
admet-2988	350	2	and	and	CCONJ
admet-2988	350	3	function	function	NOUN
admet-2988	350	4	of	of	ADP
admet-2988	350	5	the	the	DET
admet-2988	350	6	vertebrate	vertebrate	ADJ
admet-2988	350	7	and	and	CCONJ
admet-2988	350	8	invertebrate	invertebrate	NOUN
admet-2988	350	9	blood	blood	NOUN
admet-2988	350	10	-	-	PUNCT
admet-2988	350	11	brain	brain	NOUN
admet-2988	350	12	barriers	barrier	NOUN
admet-2988	350	13	.	.	PUNCT
admet-2988	351	1	international	international	ADJ
admet-2988	351	2	journal	journal	NOUN
admet-2988	351	3	of	of	ADP
admet-2988	351	4	molecular	molecular	ADJ
admet-2988	351	5	sciences	science	NOUN
admet-2988	351	6	22	22	NUM
admet-2988	351	7	(	(	PUNCT
admet-2988	351	8	2021	2021	NUM
admet-2988	351	9	)	)	PUNCT
admet-2988	351	10	12111	12111	NUM
admet-2988	351	11	.	.	PUNCT
admet-2988	352	1	https://doi.org/10.3390/ijms222212111	https://doi.org/10.3390/ijms222212111	PROPN
admet-2988	352	2	[	[	X
admet-2988	352	3	5	5	X
admet-2988	352	4	]	]	PUNCT
admet-2988	352	5	d.	d.	PROPN
admet-2988	352	6	wu	wu	PROPN
admet-2988	352	7	,	,	PUNCT
admet-2988	352	8	q.	q.	PROPN
admet-2988	352	9	chen	chen	PROPN
admet-2988	352	10	,	,	PUNCT
admet-2988	352	11	x.	x.	PROPN
admet-2988	352	12	chen	chen	PROPN
admet-2988	352	13	,	,	PUNCT
admet-2988	352	14	f.	f.	PROPN
admet-2988	352	15	han	han	PROPN
admet-2988	352	16	,	,	PUNCT
admet-2988	352	17	z.	z.	PROPN
admet-2988	352	18	chen	chen	PROPN
admet-2988	352	19	,	,	PUNCT
admet-2988	352	20	y.	y.	PROPN
admet-2988	352	21	wang	wang	PROPN
admet-2988	352	22	.	.	PUNCT
admet-2988	353	1	the	the	DET
admet-2988	353	2	blood	blood	NOUN
admet-2988	353	3	-	-	PUNCT
admet-2988	353	4	brain	brain	NOUN
admet-2988	353	5	barrier	barrier	NOUN
admet-2988	353	6	:	:	PUNCT
admet-2988	353	7	structure	structure	NOUN
admet-2988	353	8	,	,	PUNCT
admet-2988	353	9	regulation	regulation	NOUN
admet-2988	353	10	,	,	PUNCT
admet-2988	353	11	and	and	CCONJ
admet-2988	353	12	drug	drug	NOUN
admet-2988	353	13	delivery	delivery	NOUN
admet-2988	353	14	.	.	PUNCT
admet-2988	354	1	signal	signal	ADJ
admet-2988	354	2	transduction	transduction	NOUN
admet-2988	354	3	and	and	CCONJ
admet-2988	354	4	targeted	target	VERB
admet-2988	354	5	therapy	therapy	NOUN
admet-2988	354	6	8	8	NUM
admet-2988	354	7	(	(	PUNCT
admet-2988	354	8	2023	2023	NUM
admet-2988	354	9	)	)	PUNCT
admet-2988	354	10	217	217	NUM
admet-2988	354	11	.	.	PUNCT
admet-2988	355	1	https://doi.org/10.1038/s41392-023-01481-w	https://doi.org/10.1038/s41392-023-01481-w	NOUN
admet-2988	355	2	[	[	X
admet-2988	355	3	6	6	NUM
admet-2988	355	4	]	]	PUNCT
admet-2988	355	5	a.	a.	NOUN
admet-2988	355	6	dityatev	dityatev	PROPN
admet-2988	355	7	,	,	PUNCT
admet-2988	355	8	m.r	m.r	PROPN
admet-2988	355	9	.	.	PROPN
admet-2988	355	10	wilson	wilson	PROPN
admet-2988	355	11	,	,	PUNCT
admet-2988	355	12	d.	d.	PROPN
admet-2988	355	13	rusakov	rusakov	PROPN
admet-2988	355	14	,	,	PUNCT
admet-2988	355	15	c.	c.	PROPN
admet-2988	355	16	menaceur	menaceur	PROPN
admet-2988	355	17	,	,	PUNCT
admet-2988	355	18	f.	f.	PROPN
admet-2988	355	19	gosselet	gosselet	NOUN
admet-2988	355	20	,	,	PUNCT
admet-2988	355	21	l.	l.	PROPN
admet-2988	355	22	fenart	fenart	PROPN
admet-2988	355	23	,	,	PUNCT
admet-2988	355	24	j.	j.	PROPN
admet-2988	355	25	saint	saint	PROPN
admet-2988	355	26	-	-	PUNCT
admet-2988	355	27	pol	pol	NOUN
admet-2988	355	28	.	.	PUNCT
admet-2988	356	1	the	the	DET
admet-2988	356	2	bloodbrain	bloodbrain	NOUN
admet-2988	356	3	barrier	barrier	NOUN
admet-2988	356	4	,	,	PUNCT
admet-2988	356	5	an	an	DET
admet-2988	356	6	evolving	evolve	VERB
admet-2988	356	7	concept	concept	NOUN
admet-2988	356	8	based	base	VERB
admet-2988	356	9	on	on	ADP
admet-2988	356	10	technological	technological	ADJ
admet-2988	356	11	advances	advance	NOUN
admet-2988	356	12	and	and	CCONJ
admet-2988	356	13	cell	cell	NOUN
admet-2988	356	14	-	-	PUNCT
admet-2988	356	15	cell	cell	NOUN
admet-2988	356	16	communications	communication	NOUN
admet-2988	356	17	.	.	PUNCT
admet-2988	357	1	cells	cell	NOUN
admet-2988	357	2	11	11	NUM
admet-2988	357	3	(	(	PUNCT
admet-2988	357	4	2021	2021	NUM
admet-2988	357	5	)	)	PUNCT
admet-2988	357	6	133	133	NUM
admet-2988	357	7	.	.	PUNCT
admet-2988	358	1	https://doi.org/10.3390/cells11010133	https://doi.org/10.3390/cells11010133	PROPN
admet-2988	359	1	[	[	X
admet-2988	359	2	7	7	X
admet-2988	359	3	]	]	X
admet-2988	359	4	m.	m.	NOUN
admet-2988	359	5	bundgaard	bundgaard	PROPN
admet-2988	359	6	,	,	PUNCT
admet-2988	359	7	n.j	n.j	PROPN
admet-2988	359	8	.	.	PROPN
admet-2988	359	9	abbott	abbott	PROPN
admet-2988	359	10	.	.	PUNCT
admet-2988	360	1	all	all	DET
admet-2988	360	2	vertebrates	vertebrate	NOUN
admet-2988	360	3	started	start	VERB
admet-2988	360	4	out	out	ADP
admet-2988	360	5	with	with	ADP
admet-2988	360	6	a	a	DET
admet-2988	360	7	glial	glial	ADJ
admet-2988	360	8	blood	blood	NOUN
admet-2988	360	9	-	-	PUNCT
admet-2988	360	10	brain	brain	NOUN
admet-2988	360	11	barrier	barrier	NOUN
admet-2988	360	12	4	4	NUM
admet-2988	360	13	-	-	SYM
admet-2988	360	14	500	500	NUM
admet-2988	360	15	million	million	NUM
admet-2988	360	16	years	year	NOUN
admet-2988	360	17	ago	ago	ADV
admet-2988	360	18	.	.	PUNCT
admet-2988	361	1	glia	glia	PROPN
admet-2988	361	2	56	56	NUM
admet-2988	361	3	(	(	PUNCT
admet-2988	361	4	2008	2008	NUM
admet-2988	361	5	)	)	PUNCT
admet-2988	361	6	699	699	NUM
admet-2988	361	7	-	-	SYM
admet-2988	361	8	708	708	NUM
admet-2988	361	9	https://doi.org/10.1002/glia.20642	https://doi.org/10.1002/glia.20642	NOUN
admet-2988	361	10	[	[	X
admet-2988	361	11	8	8	NUM
admet-2988	361	12	]	]	X
admet-2988	361	13	c.	c.	NOUN
admet-2988	361	14	falcone	falcone	PROPN
admet-2988	361	15	.	.	PUNCT
admet-2988	362	1	evolution	evolution	NOUN
admet-2988	362	2	of	of	ADP
admet-2988	362	3	astrocytes	astrocyte	NOUN
admet-2988	362	4	:	:	PUNCT
admet-2988	362	5	from	from	ADP
admet-2988	362	6	invertebrates	invertebrate	NOUN
admet-2988	362	7	to	to	ADP
admet-2988	362	8	vertebrates	vertebrate	NOUN
admet-2988	362	9	.	.	PUNCT
admet-2988	363	1	frontiers	frontier	NOUN
admet-2988	363	2	in	in	ADP
admet-2988	363	3	cell	cell	NOUN
admet-2988	363	4	and	and	CCONJ
admet-2988	363	5	developmental	developmental	ADJ
admet-2988	363	6	biology	biology	NOUN
admet-2988	363	7	10	10	NUM
admet-2988	363	8	(	(	PUNCT
admet-2988	363	9	2022	2022	NUM
admet-2988	363	10	)	)	PUNCT
admet-2988	363	11	931311	931311	NUM
admet-2988	363	12	.	.	PUNCT
admet-2988	364	1	https://doi.org/10.3389/fcell.2022.931311	https://doi.org/10.3389/fcell.2022.931311	PRON
admet-2988	365	1	[	[	X
admet-2988	365	2	9	9	NUM
admet-2988	365	3	]	]	PUNCT
admet-2988	365	4	a.	a.	NOUN
admet-2988	365	5	verkhratsky	verkhratsky	NOUN
admet-2988	365	6	,	,	PUNCT
admet-2988	365	7	v.	v.	ADP
admet-2988	365	8	parpura	parpura	NOUN
admet-2988	365	9	,	,	PUNCT
admet-2988	365	10	b.	b.	PROPN
admet-2988	365	11	li	li	PROPN
admet-2988	365	12	,	,	PUNCT
admet-2988	365	13	c.	c.	PROPN
admet-2988	365	14	scuderi	scuderi	PROPN
admet-2988	365	15	.	.	PUNCT
admet-2988	366	1	astrocytes	astrocyte	NOUN
admet-2988	366	2	:	:	PUNCT
admet-2988	366	3	the	the	DET
admet-2988	366	4	housekeepers	housekeeper	NOUN
admet-2988	366	5	and	and	CCONJ
admet-2988	366	6	guardians	guardian	NOUN
admet-2988	366	7	of	of	ADP
admet-2988	366	8	the	the	DET
admet-2988	366	9	cns	cns	PROPN
admet-2988	366	10	.	.	PUNCT
admet-2988	367	1	advances	advance	NOUN
admet-2988	367	2	in	in	ADP
admet-2988	367	3	neurobiology	neurobiology	NOUN
admet-2988	367	4	26	26	NUM
admet-2988	367	5	(	(	PUNCT
admet-2988	367	6	2021	2021	NUM
admet-2988	367	7	)	)	PUNCT
admet-2988	367	8	21	21	NUM
admet-2988	367	9	-	-	SYM
admet-2988	367	10	53	53	NUM
admet-2988	367	11	.	.	PUNCT
admet-2988	368	1	https://doi.org/10.1007/978-3-030-77375-5_2	https://doi.org/10.1007/978-3-030-77375-5_2	NUM
admet-2988	369	1	[	[	X
admet-2988	369	2	10	10	NUM
admet-2988	369	3	]	]	X
admet-2988	369	4	v.	v.	CCONJ
admet-2988	369	5	muoio	muoio	ADJ
admet-2988	369	6	,	,	PUNCT
admet-2988	369	7	p.b	p.b	PROPN
admet-2988	369	8	.	.	PROPN
admet-2988	369	9	persson	persson	PROPN
admet-2988	369	10	,	,	PUNCT
admet-2988	369	11	m.m	m.m	PROPN
admet-2988	369	12	.	.	PROPN
admet-2988	369	13	sendeski	sendeski	PROPN
admet-2988	369	14	.	.	PUNCT
admet-2988	370	1	the	the	DET
admet-2988	370	2	neurovascular	neurovascular	ADJ
admet-2988	370	3	unit	unit	NOUN
admet-2988	370	4	concept	concept	NOUN
admet-2988	370	5	review	review	PROPN
admet-2988	370	6	.	.	PUNCT
admet-2988	371	1	acta	acta	PROPN
admet-2988	371	2	physiologica	physiologica	PROPN
admet-2988	371	3	210	210	NUM
admet-2988	371	4	(	(	PUNCT
admet-2988	371	5	2014	2014	NUM
admet-2988	371	6	)	)	PUNCT
admet-2988	371	7	790	790	NUM
admet-2988	371	8	-	-	SYM
admet-2988	371	9	798	798	NUM
admet-2988	371	10	.	.	PUNCT
admet-2988	372	1	https://doi.org/10.1111/apha.12250	https://doi.org/10.1111/apha.12250	PROPN
admet-2988	372	2	.	.	PUNCT
admet-2988	373	1	[	[	X
admet-2988	373	2	11	11	NUM
admet-2988	373	3	]	]	X
admet-2988	373	4	n.m	n.m	PROPN
admet-2988	373	5	.	.	PROPN
admet-2988	373	6	o’brown	o’brown	PROPN
admet-2988	373	7	,	,	PUNCT
admet-2988	373	8	s.j	s.j	PROPN
admet-2988	373	9	.	.	PROPN
admet-2988	373	10	pfau	pfau	PROPN
admet-2988	373	11	,	,	PUNCT
admet-2988	373	12	c.	c.	PROPN
admet-2988	373	13	gu	gu	PROPN
admet-2988	373	14	.	.	PUNCT
admet-2988	374	1	bridging	bridging	NOUN
admet-2988	374	2	barriers	barrier	NOUN
admet-2988	374	3	:	:	PUNCT
admet-2988	374	4	a	a	DET
admet-2988	374	5	comparative	comparative	ADJ
admet-2988	374	6	look	look	NOUN
admet-2988	374	7	at	at	ADP
admet-2988	374	8	the	the	DET
admet-2988	374	9	blood	blood	NOUN
admet-2988	374	10	-	-	PUNCT
admet-2988	374	11	brain	brain	NOUN
admet-2988	374	12	barrier	barrier	NOUN
admet-2988	374	13	across	across	ADP
admet-2988	374	14	organisms	organism	NOUN
admet-2988	374	15	.	.	PUNCT
admet-2988	375	1	genes	gene	NOUN
admet-2988	375	2	&	&	CCONJ
admet-2988	375	3	development	development	NOUN
admet-2988	375	4	32	32	NUM
admet-2988	375	5	(	(	PUNCT
admet-2988	375	6	2018	2018	NUM
admet-2988	375	7	)	)	PUNCT
admet-2988	375	8	466	466	NUM
admet-2988	375	9	-	-	SYM
admet-2988	375	10	478	478	NUM
admet-2988	375	11	.	.	PUNCT
admet-2988	376	1	https://doi.org/10.1101/gad.309823.117	https://doi.org/10.1101/gad.309823.117	VERB
admet-2988	377	1	[	[	X
admet-2988	377	2	12	12	NUM
admet-2988	377	3	]	]	X
admet-2988	377	4	d.	d.	PROPN
admet-2988	377	5	ribatti	ribatti	PROPN
admet-2988	377	6	,	,	PUNCT
admet-2988	377	7	b.	b.	PROPN
admet-2988	377	8	nico	nico	PROPN
admet-2988	377	9	,	,	PUNCT
admet-2988	377	10	e.	e.	PROPN
admet-2988	377	11	crivellato	crivellato	PROPN
admet-2988	377	12	,	,	PUNCT
admet-2988	377	13	m.	m.	NOUN
admet-2988	377	14	artico	artico	PROPN
admet-2988	377	15	.	.	PUNCT
admet-2988	378	1	development	development	NOUN
admet-2988	378	2	of	of	ADP
admet-2988	378	3	the	the	DET
admet-2988	378	4	blood	blood	NOUN
admet-2988	378	5	-	-	PUNCT
admet-2988	378	6	brain	brain	NOUN
admet-2988	378	7	barrier	barrier	NOUN
admet-2988	378	8	:	:	PUNCT
admet-2988	378	9	a	a	DET
admet-2988	378	10	historical	historical	ADJ
admet-2988	378	11	point	point	NOUN
admet-2988	378	12	of	of	ADP
admet-2988	378	13	view	view	NOUN
admet-2988	378	14	.	.	PUNCT
admet-2988	379	1	the	the	DET
admet-2988	379	2	anatomical	anatomical	ADJ
admet-2988	379	3	record	record	NOUN
admet-2988	379	4	part	part	NOUN
admet-2988	379	5	b	b	NOUN
admet-2988	379	6	:	:	PUNCT
admet-2988	379	7	the	the	DET
admet-2988	379	8	new	new	ADJ
admet-2988	379	9	anatomist	anatomist	NOUN
admet-2988	379	10	289b	289b	PROPN
admet-2988	379	11	(	(	PUNCT
admet-2988	379	12	2006	2006	NUM
admet-2988	379	13	)	)	PUNCT
admet-2988	379	14	3	3	NUM
admet-2988	379	15	-	-	SYM
admet-2988	379	16	8	8	NUM
admet-2988	379	17	.	.	PUNCT
admet-2988	380	1	https://doi.org/10.1002/ar.b.20087	https://doi.org/10.1002/ar.b.20087	X
admet-2988	381	1	[	[	X
admet-2988	381	2	13	13	NUM
admet-2988	381	3	]	]	X
admet-2988	381	4	davson	davson	NOUN
admet-2988	381	5	,	,	PUNCT
admet-2988	381	6	h.	h.	PROPN
admet-2988	381	7	history	history	NOUN
admet-2988	381	8	of	of	ADP
admet-2988	381	9	the	the	DET
admet-2988	381	10	blood	blood	NOUN
admet-2988	381	11	-	-	PUNCT
admet-2988	381	12	brain	brain	NOUN
admet-2988	381	13	barrier	barrier	NOUN
admet-2988	381	14	concept	concept	NOUN
admet-2988	381	15	.	.	PUNCT
admet-2988	382	1	implications	implication	NOUN
admet-2988	382	2	of	of	ADP
admet-2988	382	3	the	the	DET
admet-2988	382	4	blood	blood	NOUN
admet-2988	382	5	-	-	PUNCT
admet-2988	382	6	brain	brain	NOUN
admet-2988	382	7	barrier	barrier	NOUN
admet-2988	382	8	and	and	CCONJ
admet-2988	382	9	its	its	PRON
admet-2988	382	10	manipulation	manipulation	NOUN
admet-2988	382	11	,	,	PUNCT
admet-2988	382	12	springer	springer	NOUN
admet-2988	382	13	,	,	PUNCT
admet-2988	382	14	boston	boston	PROPN
admet-2988	382	15	ma	ma	PROPN
admet-2988	382	16	,	,	PUNCT
admet-2988	382	17	united	united	PROPN
admet-2988	382	18	states	states	PROPN
admet-2988	382	19	,	,	PUNCT
admet-2988	382	20	1989	1989	NUM
admet-2988	382	21	pp	pp	NOUN
admet-2988	382	22	.	.	PUNCT
admet-2988	383	1	27	27	NUM
admet-2988	383	2	-	-	SYM
admet-2988	383	3	52	52	NUM
admet-2988	383	4	.	.	PUNCT
admet-2988	384	1	https://doi.org/10.1007/978-14613-0701-3_2	https://doi.org/10.1007/978-14613-0701-3_2	VERB
admet-2988	385	1	[	[	X
admet-2988	385	2	14	14	NUM
admet-2988	385	3	]	]	X
admet-2988	385	4	n.r	n.r	PROPN
admet-2988	385	5	.	.	PROPN
admet-2988	385	6	saunders	saunders	PROPN
admet-2988	385	7	,	,	PUNCT
admet-2988	385	8	j.j	j.j	PROPN
admet-2988	385	9	.	.	PROPN
admet-2988	385	10	dreifuss	dreifuss	PROPN
admet-2988	385	11	,	,	PUNCT
admet-2988	385	12	k.m	k.m	PROPN
admet-2988	385	13	.	.	PROPN
admet-2988	385	14	dziegielewska	dziegielewska	PROPN
admet-2988	385	15	,	,	PUNCT
admet-2988	385	16	p.a	p.a	PROPN
admet-2988	385	17	.	.	PROPN
admet-2988	385	18	johansson	johansson	PROPN
admet-2988	385	19	,	,	PUNCT
admet-2988	385	20	m.d	m.d	PROPN
admet-2988	385	21	.	.	PROPN
admet-2988	385	22	habgood	habgood	PROPN
admet-2988	385	23	,	,	PUNCT
admet-2988	385	24	k.	k.	PROPN
admet-2988	385	25	møllgård	møllgård	PROPN
admet-2988	385	26	,	,	PUNCT
admet-2988	385	27	h.c	h.c	PROPN
admet-2988	385	28	.	.	PROPN
admet-2988	385	29	bauer	bauer	PROPN
admet-2988	385	30	.	.	PUNCT
admet-2988	386	1	the	the	DET
admet-2988	386	2	rights	right	NOUN
admet-2988	386	3	and	and	CCONJ
admet-2988	386	4	wrongs	wrong	NOUN
admet-2988	386	5	of	of	ADP
admet-2988	386	6	blood	blood	NOUN
admet-2988	386	7	-	-	PUNCT
admet-2988	386	8	brain	brain	NOUN
admet-2988	386	9	barrier	barrier	NOUN
admet-2988	386	10	permeability	permeability	NOUN
admet-2988	386	11	studies	study	NOUN
admet-2988	386	12	:	:	PUNCT
admet-2988	386	13	a	a	DET
admet-2988	386	14	walk	walk	NOUN
admet-2988	386	15	through	through	ADP
admet-2988	386	16	100	100	NUM
admet-2988	386	17	years	year	NOUN
admet-2988	386	18	of	of	ADP
admet-2988	386	19	history	history	NOUN
admet-2988	386	20	.	.	PUNCT
admet-2988	387	1	frontiers	frontier	NOUN
admet-2988	387	2	in	in	ADP
admet-2988	387	3	neuroscience	neuroscience	NOUN
admet-2988	387	4	8	8	NUM
admet-2988	387	5	(	(	PUNCT
admet-2988	387	6	2014	2014	NUM
admet-2988	387	7	)	)	PUNCT
admet-2988	387	8	1	1	NUM
admet-2988	387	9	-	-	SYM
admet-2988	387	10	26	26	NUM
admet-2988	387	11	.	.	PUNCT
admet-2988	388	1	https://doi.org/10.3389/fnins.2014.00404	https://doi.org/10.3389/fnins.2014.00404	PROPN
admet-2988	389	1	[	[	X
admet-2988	389	2	15	15	NUM
admet-2988	389	3	]	]	X
admet-2988	389	4	a.	a.	NOUN
admet-2988	389	5	villabona	villabona	PROPN
admet-2988	389	6	-	-	PUNCT
admet-2988	389	7	rueda	rueda	PROPN
admet-2988	389	8	,	,	PUNCT
admet-2988	389	9	c.	c.	PROPN
admet-2988	389	10	erice	erice	PROPN
admet-2988	389	11	,	,	PUNCT
admet-2988	389	12	c.a	c.a	PROPN
admet-2988	389	13	.	.	PROPN
admet-2988	389	14	pardo	pardo	PROPN
admet-2988	389	15	,	,	PUNCT
admet-2988	389	16	m.f	m.f	PROPN
admet-2988	389	17	.	.	PROPN
admet-2988	389	18	stins	stin	NOUN
admet-2988	389	19	.	.	PUNCT
admet-2988	390	1	the	the	DET
admet-2988	390	2	evolving	evolve	VERB
admet-2988	390	3	concept	concept	NOUN
admet-2988	390	4	of	of	ADP
admet-2988	390	5	the	the	DET
admet-2988	390	6	blood	blood	NOUN
admet-2988	390	7	brain	brain	NOUN
admet-2988	390	8	barrier	barrier	NOUN
admet-2988	390	9	(	(	PUNCT
admet-2988	390	10	bbb	bbb	PROPN
admet-2988	390	11	):	):	PUNCT
admet-2988	390	12	from	from	ADP
admet-2988	390	13	a	a	DET
admet-2988	390	14	single	single	ADJ
admet-2988	390	15	static	static	ADJ
admet-2988	390	16	barrier	barrier	NOUN
admet-2988	390	17	to	to	ADP
admet-2988	390	18	a	a	DET
admet-2988	390	19	heterogeneous	heterogeneous	ADJ
admet-2988	390	20	and	and	CCONJ
admet-2988	390	21	dynamic	dynamic	ADJ
admet-2988	390	22	relay	relay	NOUN
admet-2988	390	23	center	center	NOUN
admet-2988	390	24	.	.	PUNCT
admet-2988	391	1	frontiers	frontier	NOUN
admet-2988	391	2	in	in	ADP
admet-2988	391	3	cellular	cellular	ADJ
admet-2988	391	4	neuroscience	neuroscience	NOUN
admet-2988	391	5	13	13	NUM
admet-2988	391	6	405	405	NUM
admet-2988	391	7	(	(	PUNCT
admet-2988	391	8	2019	2019	NUM
admet-2988	391	9	)	)	PUNCT
admet-2988	391	10	405	405	NUM
admet-2988	391	11	.	.	PUNCT
admet-2988	392	1	https://doi.org/10.3389/fncel.2019.00405	https://doi.org/10.3389/fncel.2019.00405	PROPN
admet-2988	393	1	[	[	X
admet-2988	393	2	16	16	NUM
admet-2988	393	3	]	]	X
admet-2988	393	4	w.m	w.m	PROPN
admet-2988	393	5	.	.	PROPN
admet-2988	393	6	pardridge	pardridge	PROPN
admet-2988	393	7	.	.	PUNCT
admet-2988	394	1	a	a	DET
admet-2988	394	2	historical	historical	ADJ
admet-2988	394	3	review	review	NOUN
admet-2988	394	4	of	of	ADP
admet-2988	394	5	brain	brain	NOUN
admet-2988	394	6	drug	drug	NOUN
admet-2988	394	7	delivery	delivery	NOUN
admet-2988	394	8	.	.	PUNCT
admet-2988	395	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	395	2	14	14	NUM
admet-2988	395	3	(	(	PUNCT
admet-2988	395	4	2022	2022	NUM
admet-2988	395	5	)	)	PUNCT
admet-2988	395	6	1283	1283	NUM
admet-2988	395	7	.	.	PUNCT
admet-2988	396	1	https://doi.org/10.3390/pharmaceutics14061283	https://doi.org/10.3390/pharmaceutics14061283	PROPN
admet-2988	397	1	[	[	X
admet-2988	397	2	17	17	NUM
admet-2988	397	3	]	]	PUNCT
admet-2988	397	4	s.	s.	PROPN
admet-2988	397	5	schaeffer	schaeffer	PROPN
admet-2988	397	6	,	,	PUNCT
admet-2988	397	7	c.	c.	PROPN
admet-2988	397	8	iadecola	iadecola	PROPN
admet-2988	397	9	.	.	PUNCT
admet-2988	398	1	revisiting	revisit	VERB
admet-2988	398	2	the	the	DET
admet-2988	398	3	neurovascular	neurovascular	ADJ
admet-2988	398	4	unit	unit	NOUN
admet-2988	398	5	.	.	PUNCT
admet-2988	399	1	nature	nature	NOUN
admet-2988	399	2	neuroscience	neuroscience	NOUN
admet-2988	399	3	24	24	NUM
admet-2988	399	4	9	9	NUM
admet-2988	399	5	(	(	PUNCT
admet-2988	399	6	2021	2021	NUM
admet-2988	399	7	)	)	PUNCT
admet-2988	399	8	11981209	11981209	NUM
admet-2988	399	9	.	.	PUNCT
admet-2988	400	1	https://doi.org/10.1038/s41593-021-00904-7	https://doi.org/10.1038/s41593-021-00904-7	PROPN
admet-2988	401	1	https://doi.org/10.1016/j.cub.2016.09.003	https://doi.org/10.1016/j.cub.2016.09.003	NOUN
admet-2988	401	2	https://doi.org/10.1098/rstb.2015.0428	https://doi.org/10.1098/rstb.2015.0428	PROPN
admet-2988	401	3	https://doi.org/10.1007/s11064-021-03338-6	https://doi.org/10.1007/s11064-021-03338-6	NUM
admet-2988	401	4	https://doi.org/10.3390/ijms222212111	https://doi.org/10.3390/ijms222212111	NOUN
admet-2988	401	5	https://doi.org/10.1038/s41392-023-01481-w	https://doi.org/10.1038/s41392-023-01481-w	PROPN
admet-2988	401	6	https://doi.org/10.3390/cells11010133	https://doi.org/10.3390/cells11010133	VERB
admet-2988	401	7	https://doi.org/10.1002/glia.20642	https://doi.org/10.1002/glia.20642	VERB
admet-2988	401	8	https://doi.org/10.3389/fcell.2022.931311	https://doi.org/10.3389/fcell.2022.931311	PRON
admet-2988	401	9	https://doi.org/10.1007/978-3-030-77375-5_2/figures/9	https://doi.org/10.1007/978-3-030-77375-5_2/figures/9	PROPN
admet-2988	401	10	https://doi.org/10.1111/apha.12250	https://doi.org/10.1111/apha.12250	PROPN
admet-2988	401	11	https://doi.org/10.1101/gad.309823.117	https://doi.org/10.1101/gad.309823.117	PROPN
admet-2988	401	12	https://doi.org/10.1002/ar.b.20087	https://doi.org/10.1002/ar.b.20087	NOUN
admet-2988	401	13	https://doi.org/10.1007/978-1-4613-0701-3_2	https://doi.org/10.1007/978-1-4613-0701-3_2	PROPN
admet-2988	401	14	https://doi.org/10.1007/978-1-4613-0701-3_2	https://doi.org/10.1007/978-1-4613-0701-3_2	PROPN
admet-2988	401	15	https://doi.org/10.3389/fnins.2014.00404	https://doi.org/10.3389/fnins.2014.00404	PROPN
admet-2988	401	16	https://doi.org/10.3389/fncel.2019.00405	https://doi.org/10.3389/fncel.2019.00405	PROPN
admet-2988	401	17	https://doi.org/10.3390/pharmaceutics14061283	https://doi.org/10.3390/pharmaceutics14061283	NOUN
admet-2988	401	18	https://doi.org/10.1038/s41593-021-00904-7	https://doi.org/10.1038/s41593-021-00904-7	PROPN
admet-2988	401	19	admet	admet	PROPN
admet-2988	401	20	&	&	CCONJ
admet-2988	401	21	dmpk	dmpk	PROPN
admet-2988	401	22	13(5	13(5	NUM
admet-2988	401	23	)	)	PUNCT
admet-2988	401	24	(	(	PUNCT
admet-2988	401	25	2025	2025	NUM
admet-2988	401	26	)	)	PUNCT
admet-2988	401	27	2988	2988	NUM
admet-2988	401	28	advancing	advance	VERB
admet-2988	401	29	through	through	ADP
admet-2988	401	30	the	the	DET
admet-2988	401	31	blood	blood	NOUN
admet-2988	401	32	-	-	PUNCT
admet-2988	401	33	brain	brain	NOUN
admet-2988	401	34	barrier	barrier	NOUN
admet-2988	401	35	doi	doi	NOUN
admet-2988	401	36	:	:	PUNCT
admet-2988	401	37	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	401	38	17	17	NUM
admet-2988	401	39	[	[	SYM
admet-2988	401	40	18	18	NUM
admet-2988	401	41	]	]	X
admet-2988	401	42	c.	c.	PROPN
admet-2988	401	43	iadecola	iadecola	PROPN
admet-2988	401	44	.	.	PUNCT
admet-2988	402	1	the	the	DET
admet-2988	402	2	neurovascular	neurovascular	ADJ
admet-2988	402	3	unit	unit	NOUN
admet-2988	402	4	coming	come	VERB
admet-2988	402	5	of	of	ADP
admet-2988	402	6	age	age	NOUN
admet-2988	402	7	:	:	PUNCT
admet-2988	402	8	a	a	DET
admet-2988	402	9	journey	journey	NOUN
admet-2988	402	10	through	through	ADP
admet-2988	402	11	neurovascular	neurovascular	ADJ
admet-2988	402	12	coupling	coupling	NOUN
admet-2988	402	13	in	in	ADP
admet-2988	402	14	health	health	NOUN
admet-2988	402	15	and	and	CCONJ
admet-2988	402	16	disease	disease	PROPN
admet-2988	402	17	.	.	PUNCT
admet-2988	403	1	neuron	neuron	PROPN
admet-2988	403	2	96	96	NUM
admet-2988	403	3	(	(	PUNCT
admet-2988	403	4	2017	2017	NUM
admet-2988	403	5	)	)	PUNCT
admet-2988	403	6	17	17	NUM
admet-2988	403	7	-	-	SYM
admet-2988	403	8	42	42	NUM
admet-2988	403	9	.	.	PUNCT
admet-2988	404	1	https://doi.org/10.1016/j.neuron.2017.07.030	https://doi.org/10.1016/j.neuron.2017.07.030	NUM
admet-2988	404	2	[	[	X
admet-2988	404	3	19	19	NUM
admet-2988	404	4	]	]	X
admet-2988	404	5	r.	r.	PROPN
admet-2988	404	6	vargas	vargas	PROPN
admet-2988	404	7	,	,	PUNCT
admet-2988	404	8	c.	c.	PROPN
admet-2988	404	9	lizano	lizano	PROPN
admet-2988	404	10	-	-	PUNCT
admet-2988	404	11	barrantes	barrante	NOUN
admet-2988	404	12	,	,	PUNCT
admet-2988	404	13	m.	m.	PROPN
admet-2988	404	14	romero	romero	PROPN
admet-2988	404	15	,	,	PUNCT
admet-2988	404	16	k.	k.	PROPN
admet-2988	404	17	valencia	valencia	PROPN
admet-2988	404	18	-	-	PUNCT
admet-2988	404	19	clua	clua	NOUN
admet-2988	404	20	,	,	PUNCT
admet-2988	404	21	d.a	d.a	PROPN
admet-2988	404	22	.	.	PROPN
admet-2988	404	23	narváez	narváez	PROPN
admet-2988	404	24	-	-	PUNCT
admet-2988	404	25	narváez	narváez	PROPN
admet-2988	404	26	,	,	PUNCT
admet-2988	404	27	j.m	j.m	PROPN
admet-2988	404	28	.	.	PROPN
admet-2988	404	29	suñénegre	suñénegre	NOUN
admet-2988	404	30	,	,	PUNCT
admet-2988	404	31	p.	p.	NOUN
admet-2988	404	32	pérez	pérez	NOUN
admet-2988	404	33	-	-	PUNCT
admet-2988	404	34	lozano	lozano	PROPN
admet-2988	404	35	,	,	PUNCT
admet-2988	404	36	e.	e.	PROPN
admet-2988	404	37	garcía	garcía	PROPN
admet-2988	404	38	-	-	PUNCT
admet-2988	404	39	montoya	montoya	NOUN
admet-2988	404	40	,	,	PUNCT
admet-2988	404	41	n.	n.	PROPN
admet-2988	404	42	martinez	martinez	PROPN
admet-2988	404	43	-	-	PUNCT
admet-2988	404	44	martinez	martinez	PROPN
admet-2988	404	45	,	,	PUNCT
admet-2988	404	46	c.	c.	PROPN
admet-2988	404	47	hernández	hernández	PROPN
admet-2988	404	48	-	-	PUNCT
admet-2988	404	49	munain	munain	PROPN
admet-2988	404	50	,	,	PUNCT
admet-2988	404	51	c.	c.	NOUN
admet-2988	404	52	suñé	suñé	PROPN
admet-2988	404	53	,	,	PUNCT
admet-2988	404	54	m.	m.	NOUN
admet-2988	404	55	suñé	suñé	PROPN
admet-2988	404	56	-	-	PUNCT
admet-2988	404	57	pou	pou	PROPN
admet-2988	404	58	.	.	PUNCT
admet-2988	405	1	the	the	DET
admet-2988	405	2	piper	piper	NOUN
admet-2988	405	3	at	at	ADP
admet-2988	405	4	the	the	DET
admet-2988	405	5	gates	gate	NOUN
admet-2988	405	6	of	of	ADP
admet-2988	405	7	brain	brain	NOUN
admet-2988	405	8	:	:	PUNCT
admet-2988	405	9	a	a	DET
admet-2988	405	10	systematic	systematic	ADJ
admet-2988	405	11	review	review	NOUN
admet-2988	405	12	of	of	ADP
admet-2988	405	13	surface	surface	NOUN
admet-2988	405	14	modification	modification	NOUN
admet-2988	405	15	strategies	strategy	NOUN
admet-2988	405	16	on	on	ADP
admet-2988	405	17	lipid	lipid	ADJ
admet-2988	405	18	nanoparticles	nanoparticle	NOUN
admet-2988	405	19	to	to	PART
admet-2988	405	20	overcome	overcome	VERB
admet-2988	405	21	the	the	DET
admet-2988	405	22	blood	blood	NOUN
admet-2988	405	23	-	-	PUNCT
admet-2988	405	24	brain	brain	NOUN
admet-2988	405	25	-	-	PUNCT
admet-2988	405	26	barrier	barrier	NOUN
admet-2988	405	27	.	.	PUNCT
admet-2988	406	1	international	international	ADJ
admet-2988	406	2	journal	journal	PROPN
admet-2988	406	3	of	of	ADP
admet-2988	406	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	406	5	665	665	NUM
admet-2988	406	6	124868	124868	NUM
admet-2988	406	7	(	(	PUNCT
admet-2988	406	8	2024	2024	NUM
admet-2988	406	9	)	)	PUNCT
admet-2988	406	10	124686	124686	NUM
admet-2988	406	11	.	.	PUNCT
admet-2988	407	1	https://doi.org/10.1016/j.ijpharm.2024.124686	https://doi.org/10.1016/j.ijpharm.2024.124686	ADJ
admet-2988	407	2	[	[	X
admet-2988	407	3	20	20	NUM
admet-2988	407	4	]	]	PUNCT
admet-2988	407	5	a.	a.	PROPN
admet-2988	407	6	mishra	mishra	PROPN
admet-2988	407	7	,	,	PUNCT
admet-2988	407	8	r.	r.	PROPN
admet-2988	407	9	kumar	kumar	PROPN
admet-2988	407	10	,	,	PUNCT
admet-2988	407	11	j.	j.	PROPN
admet-2988	407	12	mishra	mishra	PROPN
admet-2988	407	13	,	,	PUNCT
admet-2988	407	14	k.	k.	PROPN
admet-2988	407	15	dutta	dutta	PROPN
admet-2988	407	16	,	,	PUNCT
admet-2988	407	17	p.	p.	PROPN
admet-2988	407	18	ahlawat	ahlawat	PROPN
admet-2988	407	19	,	,	PUNCT
admet-2988	407	20	a.	a.	PROPN
admet-2988	407	21	kumar	kumar	PROPN
admet-2988	407	22	,	,	PUNCT
admet-2988	407	23	s.	s.	PROPN
admet-2988	407	24	dhanasekaran	dhanasekaran	PROPN
admet-2988	407	25	,	,	PUNCT
admet-2988	407	26	a.k	a.k	PROPN
admet-2988	407	27	.	.	PROPN
admet-2988	407	28	gupta	gupta	PROPN
admet-2988	407	29	,	,	PUNCT
admet-2988	407	30	s.	s.	PROPN
admet-2988	407	31	sinha	sinha	PROPN
admet-2988	407	32	,	,	PUNCT
admet-2988	408	1	d.k	d.k	PROPN
admet-2988	408	2	.	.	PROPN
admet-2988	408	3	bishi	bishi	PROPN
admet-2988	408	4	,	,	PUNCT
admet-2988	408	5	p.k	p.k	PROPN
admet-2988	408	6	.	.	PROPN
admet-2988	408	7	gupta	gupta	PROPN
admet-2988	408	8	,	,	PUNCT
admet-2988	408	9	s.	s.	PROPN
admet-2988	408	10	nayak	nayak	PROPN
admet-2988	408	11	.	.	PUNCT
admet-2988	409	1	strategies	strategy	NOUN
admet-2988	409	2	facilitating	facilitate	VERB
admet-2988	409	3	the	the	DET
admet-2988	409	4	permeation	permeation	NOUN
admet-2988	409	5	of	of	ADP
admet-2988	409	6	nanoparticles	nanoparticle	NOUN
admet-2988	409	7	through	through	ADP
admet-2988	409	8	blood	blood	NOUN
admet-2988	409	9	-	-	PUNCT
admet-2988	409	10	brain	brain	NOUN
admet-2988	409	11	barrier	barrier	NOUN
admet-2988	409	12	:	:	PUNCT
admet-2988	409	13	an	an	DET
admet-2988	409	14	insight	insight	NOUN
admet-2988	409	15	towards	towards	ADP
admet-2988	409	16	the	the	DET
admet-2988	409	17	development	development	NOUN
admet-2988	409	18	of	of	ADP
admet-2988	409	19	brain	brain	NOUN
admet-2988	409	20	-	-	PUNCT
admet-2988	409	21	targeted	target	VERB
admet-2988	409	22	drug	drug	NOUN
admet-2988	409	23	delivery	delivery	NOUN
admet-2988	409	24	system	system	NOUN
admet-2988	409	25	.	.	PUNCT
admet-2988	410	1	journal	journal	PROPN
admet-2988	410	2	of	of	ADP
admet-2988	410	3	drug	drug	NOUN
admet-2988	410	4	delivery	delivery	NOUN
admet-2988	410	5	science	science	NOUN
admet-2988	410	6	and	and	CCONJ
admet-2988	410	7	technology	technology	NOUN
admet-2988	410	8	86	86	NUM
admet-2988	410	9	(	(	PUNCT
admet-2988	410	10	2023	2023	NUM
admet-2988	410	11	)	)	PUNCT
admet-2988	410	12	104694	104694	NUM
admet-2988	410	13	.	.	PUNCT
admet-2988	411	1	https://doi.org/10.1016/j.jddst.2023.104694	https://doi.org/10.1016/j.jddst.2023.104694	PROPN
admet-2988	411	2	[	[	X
admet-2988	411	3	21	21	NUM
admet-2988	411	4	]	]	PUNCT
admet-2988	411	5	a.	a.	NOUN
admet-2988	411	6	akhtar	akhtar	PROPN
admet-2988	411	7	,	,	PUNCT
admet-2988	411	8	a.	a.	PROPN
admet-2988	411	9	andleeb	andleeb	PROPN
admet-2988	411	10	,	,	PUNCT
admet-2988	411	11	t.s	t.s	PROPN
admet-2988	411	12	.	.	PROPN
admet-2988	411	13	waris	waris	PROPN
admet-2988	411	14	,	,	PUNCT
admet-2988	411	15	m.	m.	NOUN
admet-2988	411	16	bazzar	bazzar	PROPN
admet-2988	411	17	,	,	PUNCT
admet-2988	411	18	a.r	a.r	PROPN
admet-2988	411	19	.	.	PROPN
admet-2988	411	20	moradi	moradi	PROPN
admet-2988	411	21	,	,	PUNCT
admet-2988	411	22	n.r	n.r	PROPN
admet-2988	411	23	.	.	PROPN
admet-2988	411	24	awan	awan	PROPN
admet-2988	411	25	,	,	PUNCT
admet-2988	411	26	m.	m.	NOUN
admet-2988	411	27	yar	yar	PROPN
admet-2988	411	28	.	.	PUNCT
admet-2988	411	29	neurodegenerative	neurodegenerative	ADJ
admet-2988	411	30	diseases	disease	NOUN
admet-2988	411	31	and	and	CCONJ
admet-2988	411	32	effective	effective	ADJ
admet-2988	411	33	drug	drug	NOUN
admet-2988	411	34	delivery	delivery	NOUN
admet-2988	411	35	:	:	PUNCT
admet-2988	411	36	a	a	DET
admet-2988	411	37	review	review	NOUN
admet-2988	411	38	of	of	ADP
admet-2988	411	39	challenges	challenge	NOUN
admet-2988	411	40	and	and	CCONJ
admet-2988	411	41	novel	novel	ADJ
admet-2988	411	42	therapeutics	therapeutic	NOUN
admet-2988	411	43	.	.	PUNCT
admet-2988	412	1	journal	journal	PROPN
admet-2988	412	2	of	of	ADP
admet-2988	412	3	controlled	control	VERB
admet-2988	412	4	release	release	NOUN
admet-2988	412	5	330	330	NUM
admet-2988	412	6	(	(	PUNCT
admet-2988	412	7	2021	2021	NUM
admet-2988	412	8	)	)	PUNCT
admet-2988	412	9	1152	1152	NUM
admet-2988	412	10	-	-	SYM
admet-2988	412	11	1167	1167	NUM
admet-2988	412	12	.	.	PUNCT
admet-2988	413	1	https://doi.org/10.1016/j.jconrel.2020.11.021	https://doi.org/10.1016/j.jconrel.2020.11.021	PROPN
admet-2988	414	1	[	[	X
admet-2988	414	2	22	22	NUM
admet-2988	414	3	]	]	X
admet-2988	414	4	g.	g.	PROPN
admet-2988	414	5	guillama	guillama	PROPN
admet-2988	414	6	barroso	barroso	PROPN
admet-2988	414	7	,	,	PUNCT
admet-2988	414	8	m.	m.	NOUN
admet-2988	414	9	narayan	narayan	PROPN
admet-2988	414	10	,	,	PUNCT
admet-2988	414	11	m.	m.	NOUN
admet-2988	414	12	alvarado	alvarado	PROPN
admet-2988	414	13	,	,	PUNCT
admet-2988	414	14	i.	i.	PROPN
admet-2988	414	15	armendariz	armendariz	PROPN
admet-2988	414	16	,	,	PUNCT
admet-2988	414	17	j.	j.	PROPN
admet-2988	414	18	bernal	bernal	PROPN
admet-2988	414	19	,	,	PUNCT
admet-2988	414	20	x.	x.	NOUN
admet-2988	414	21	carabaza	carabaza	PROPN
admet-2988	414	22	,	,	PUNCT
admet-2988	414	23	s.	s.	PROPN
admet-2988	414	24	chavez	chavez	PROPN
admet-2988	414	25	,	,	PUNCT
admet-2988	414	26	p.	p.	NOUN
admet-2988	414	27	cruz	cruz	PROPN
admet-2988	414	28	,	,	PUNCT
admet-2988	414	29	v.	v.	PROPN
admet-2988	414	30	escalante	escalante	PROPN
admet-2988	414	31	,	,	PUNCT
admet-2988	414	32	s.	s.	PROPN
admet-2988	414	33	estorga	estorga	PROPN
admet-2988	414	34	,	,	PUNCT
admet-2988	414	35	d.	d.	PROPN
admet-2988	414	36	fernandez	fernandez	PROPN
admet-2988	414	37	,	,	PUNCT
admet-2988	414	38	c.	c.	PROPN
admet-2988	414	39	lozano	lozano	PROPN
admet-2988	414	40	,	,	PUNCT
admet-2988	414	41	m.	m.	PROPN
admet-2988	414	42	marrufo	marrufo	PROPN
admet-2988	414	43	,	,	PUNCT
admet-2988	414	44	n.	n.	PROPN
admet-2988	414	45	ahmad	ahmad	PROPN
admet-2988	414	46	,	,	PUNCT
admet-2988	414	47	s.	s.	PROPN
admet-2988	414	48	negrete	negrete	PROPN
admet-2988	414	49	,	,	PUNCT
admet-2988	414	50	k.	k.	PROPN
admet-2988	414	51	olvera	olvera	PROPN
admet-2988	414	52	,	,	PUNCT
admet-2988	414	53	x.	x.	PROPN
admet-2988	414	54	parada	parada	PROPN
admet-2988	414	55	,	,	PUNCT
admet-2988	414	56	b.	b.	PROPN
admet-2988	414	57	portillo	portillo	PROPN
admet-2988	414	58	,	,	PUNCT
admet-2988	414	59	a.	a.	PROPN
admet-2988	414	60	ramirez	ramirez	PROPN
admet-2988	414	61	,	,	PUNCT
admet-2988	414	62	r.	r.	PROPN
admet-2988	414	63	ramos	ramos	PROPN
admet-2988	414	64	,	,	PUNCT
admet-2988	414	65	v.	v.	PROPN
admet-2988	414	66	rodriguez	rodriguez	PROPN
admet-2988	414	67	,	,	PUNCT
admet-2988	414	68	p.	p.	PROPN
admet-2988	414	69	rojas	rojas	PROPN
admet-2988	414	70	,	,	PUNCT
admet-2988	414	71	j.	j.	PROPN
admet-2988	414	72	romero	romero	PROPN
admet-2988	414	73	,	,	PUNCT
admet-2988	414	74	d.	d.	PROPN
admet-2988	414	75	suarez	suarez	PROPN
admet-2988	414	76	,	,	PUNCT
admet-2988	414	77	g.	g.	PROPN
admet-2988	414	78	urueta	urueta	PROPN
admet-2988	414	79	,	,	PUNCT
admet-2988	414	80	s.	s.	PROPN
admet-2988	414	81	viel	viel	PROPN
admet-2988	414	82	.	.	PUNCT
admet-2988	415	1	nanocarriers	nanocarrier	NOUN
admet-2988	415	2	as	as	ADP
admet-2988	415	3	potential	potential	ADJ
admet-2988	415	4	drug	drug	NOUN
admet-2988	415	5	delivery	delivery	NOUN
admet-2988	415	6	candidates	candidate	NOUN
admet-2988	415	7	for	for	ADP
admet-2988	415	8	overcoming	overcome	VERB
admet-2988	415	9	the	the	DET
admet-2988	415	10	blood	blood	NOUN
admet-2988	415	11	-	-	PUNCT
admet-2988	415	12	brain	brain	NOUN
admet-2988	415	13	barrier	barrier	NOUN
admet-2988	415	14	:	:	PUNCT
admet-2988	415	15	challenges	challenge	NOUN
admet-2988	415	16	and	and	CCONJ
admet-2988	415	17	possibilities	possibility	NOUN
admet-2988	415	18	.	.	PUNCT
admet-2988	416	1	acs	acs	PROPN
admet-2988	416	2	omega	omega	NOUN
admet-2988	416	3	5	5	NUM
admet-2988	416	4	(	(	PUNCT
admet-2988	416	5	2020	2020	NUM
admet-2988	416	6	)	)	PUNCT
admet-2988	416	7	12583	12583	NUM
admet-2988	416	8	-	-	SYM
admet-2988	416	9	12595	12595	NUM
admet-2988	416	10	.	.	PUNCT
admet-2988	417	1	https://doi.org/10.1021/acsomega.0c01592	https://doi.org/10.1021/acsomega.0c01592	PRON
admet-2988	418	1	[	[	X
admet-2988	418	2	23	23	NUM
admet-2988	418	3	]	]	X
admet-2988	418	4	n.	n.	PROPN
admet-2988	418	5	weiss	weiss	PROPN
admet-2988	418	6	,	,	PUNCT
admet-2988	418	7	f.	f.	PROPN
admet-2988	418	8	miller	miller	PROPN
admet-2988	418	9	,	,	PUNCT
admet-2988	418	10	s.	s.	PROPN
admet-2988	418	11	cazaubon	cazaubon	PROPN
admet-2988	418	12	,	,	PUNCT
admet-2988	418	13	p.o	p.o	PROPN
admet-2988	418	14	.	.	PROPN
admet-2988	418	15	couraud	couraud	PROPN
admet-2988	418	16	.	.	PUNCT
admet-2988	419	1	the	the	DET
admet-2988	419	2	blood	blood	NOUN
admet-2988	419	3	-	-	PUNCT
admet-2988	419	4	brain	brain	NOUN
admet-2988	419	5	barrier	barrier	NOUN
admet-2988	419	6	in	in	ADP
admet-2988	419	7	brain	brain	NOUN
admet-2988	419	8	homeostasis	homeostasis	NOUN
admet-2988	419	9	and	and	CCONJ
admet-2988	419	10	neurological	neurological	ADJ
admet-2988	419	11	diseases	disease	NOUN
admet-2988	419	12	.	.	PUNCT
admet-2988	420	1	biochimica	biochimica	PROPN
admet-2988	420	2	et	et	PROPN
admet-2988	420	3	biophysica	biophysica	PROPN
admet-2988	420	4	acta	acta	PROPN
admet-2988	420	5	biomembranes	biomembrane	VERB
admet-2988	420	6	1788	1788	NUM
admet-2988	420	7	(	(	PUNCT
admet-2988	420	8	2009	2009	NUM
admet-2988	420	9	)	)	PUNCT
admet-2988	420	10	842	842	NUM
admet-2988	420	11	-	-	SYM
admet-2988	420	12	857	857	NUM
admet-2988	420	13	.	.	PUNCT
admet-2988	421	1	https://doi.org/10.1016/j.bbamem.2008.10.022	https://doi.org/10.1016/j.bbamem.2008.10.022	PROPN
admet-2988	421	2	[	[	X
admet-2988	421	3	24	24	NUM
admet-2988	421	4	]	]	SYM
admet-2988	421	5	n.j	n.j	PROPN
admet-2988	421	6	.	.	PROPN
admet-2988	421	7	abbott	abbott	PROPN
admet-2988	421	8	,	,	PUNCT
admet-2988	421	9	a.a.k	a.a.k	PROPN
admet-2988	421	10	.	.	PUNCT
admet-2988	421	11	patabendige	patabendige	PROPN
admet-2988	421	12	,	,	PUNCT
admet-2988	421	13	d.e.m	d.e.m	PROPN
admet-2988	421	14	.	.	PUNCT
admet-2988	422	1	dolman	dolman	PROPN
admet-2988	422	2	,	,	PUNCT
admet-2988	422	3	s.r	s.r	PROPN
admet-2988	422	4	.	.	PROPN
admet-2988	422	5	yusof	yusof	PROPN
admet-2988	422	6	,	,	PUNCT
admet-2988	422	7	d.j	d.j	PROPN
admet-2988	422	8	.	.	PROPN
admet-2988	422	9	begley	begley	PROPN
admet-2988	422	10	.	.	PUNCT
admet-2988	423	1	structure	structure	NOUN
admet-2988	423	2	and	and	CCONJ
admet-2988	423	3	function	function	NOUN
admet-2988	423	4	of	of	ADP
admet-2988	423	5	the	the	DET
admet-2988	423	6	blood	blood	NOUN
admet-2988	423	7	-	-	PUNCT
admet-2988	423	8	brain	brain	NOUN
admet-2988	423	9	barrier	barrier	NOUN
admet-2988	423	10	.	.	PUNCT
admet-2988	424	1	neurobiology	neurobiology	NOUN
admet-2988	424	2	of	of	ADP
admet-2988	424	3	disease	disease	NOUN
admet-2988	424	4	37	37	NUM
admet-2988	424	5	(	(	PUNCT
admet-2988	424	6	2010	2010	NUM
admet-2988	424	7	)	)	PUNCT
admet-2988	424	8	13	13	NUM
admet-2988	424	9	-	-	SYM
admet-2988	424	10	25	25	NUM
admet-2988	424	11	.	.	PUNCT
admet-2988	425	1	https://doi.org/10.1016/j.nbd.2009.07.030	https://doi.org/10.1016/j.nbd.2009.07.030	PROPN
admet-2988	426	1	[	[	X
admet-2988	426	2	25	25	NUM
admet-2988	426	3	]	]	X
admet-2988	426	4	c.	c.	PROPN
admet-2988	426	5	culkins	culkins	PROPN
admet-2988	426	6	,	,	PUNCT
admet-2988	426	7	r.	r.	PROPN
admet-2988	426	8	adomanis	adomanis	PROPN
admet-2988	426	9	,	,	PUNCT
admet-2988	426	10	n.	n.	PROPN
admet-2988	426	11	phan	phan	PROPN
admet-2988	426	12	,	,	PUNCT
admet-2988	426	13	b.	b.	PROPN
admet-2988	426	14	robinson	robinson	PROPN
admet-2988	426	15	,	,	PUNCT
admet-2988	426	16	e.	e.	PROPN
admet-2988	426	17	slaton	slaton	PROPN
admet-2988	426	18	,	,	PUNCT
admet-2988	426	19	e.	e.	PROPN
admet-2988	426	20	lothrop	lothrop	PROPN
admet-2988	426	21	,	,	PUNCT
admet-2988	426	22	y.	y.	PROPN
admet-2988	426	23	chen	chen	PROPN
admet-2988	426	24	,	,	PUNCT
admet-2988	426	25	b.r	b.r	PROPN
admet-2988	426	26	.	.	PROPN
admet-2988	426	27	kimmel	kimmel	PROPN
admet-2988	426	28	.	.	PUNCT
admet-2988	427	1	unlocking	unlock	VERB
admet-2988	427	2	the	the	DET
admet-2988	427	3	gates	gate	NOUN
admet-2988	427	4	:	:	PUNCT
admet-2988	427	5	therapeutic	therapeutic	ADJ
admet-2988	427	6	agents	agent	NOUN
admet-2988	427	7	for	for	ADP
admet-2988	427	8	noninvasive	noninvasive	ADJ
admet-2988	427	9	drug	drug	NOUN
admet-2988	427	10	delivery	delivery	NOUN
admet-2988	427	11	across	across	ADP
admet-2988	427	12	the	the	DET
admet-2988	427	13	blood	blood	NOUN
admet-2988	427	14	-	-	PUNCT
admet-2988	427	15	brain	brain	NOUN
admet-2988	427	16	barrier	barrier	NOUN
admet-2988	427	17	.	.	PUNCT
admet-2988	428	1	molecular	molecular	ADJ
admet-2988	428	2	pharmaceutics	pharmaceutic	NOUN
admet-2988	428	3	21	21	NUM
admet-2988	428	4	(	(	PUNCT
admet-2988	428	5	2024	2024	NUM
admet-2988	428	6	)	)	PUNCT
admet-2988	428	7	5430	5430	NUM
admet-2988	428	8	-	-	SYM
admet-2988	428	9	5454	5454	NUM
admet-2988	428	10	.	.	PUNCT
admet-2988	429	1	https://doi.org/10.1021/acs.molpharmaceut.4c00604	https://doi.org/10.1021/acs.molpharmaceut.4c00604	X
admet-2988	430	1	[	[	X
admet-2988	430	2	26	26	NUM
admet-2988	430	3	]	]	PUNCT
admet-2988	430	4	k.	k.	PROPN
admet-2988	430	5	wanat	wanat	PROPN
admet-2988	430	6	.	.	PUNCT
admet-2988	431	1	biological	biological	ADJ
admet-2988	431	2	barriers	barrier	NOUN
admet-2988	431	3	,	,	PUNCT
admet-2988	431	4	and	and	CCONJ
admet-2988	431	5	the	the	DET
admet-2988	431	6	influence	influence	NOUN
admet-2988	431	7	of	of	ADP
admet-2988	431	8	protein	protein	NOUN
admet-2988	431	9	binding	bind	VERB
admet-2988	431	10	on	on	ADP
admet-2988	431	11	the	the	DET
admet-2988	431	12	passage	passage	NOUN
admet-2988	431	13	of	of	ADP
admet-2988	431	14	drugs	drug	NOUN
admet-2988	431	15	across	across	ADP
admet-2988	431	16	them	they	PRON
admet-2988	431	17	.	.	PUNCT
admet-2988	432	1	molecular	molecular	ADJ
admet-2988	432	2	biology	biology	NOUN
admet-2988	432	3	reports	report	VERB
admet-2988	432	4	47(4	47(4	NOUN
admet-2988	432	5	)	)	PUNCT
admet-2988	432	6	(	(	PUNCT
admet-2988	432	7	2020	2020	NUM
admet-2988	432	8	)	)	PUNCT
admet-2988	432	9	3221	3221	NUM
admet-2988	432	10	-	-	SYM
admet-2988	432	11	3231	3231	NUM
admet-2988	432	12	.	.	PUNCT
admet-2988	433	1	https://doi.org/10.1007/s11033-020-05361-2	https://doi.org/10.1007/s11033-020-05361-2	NOUN
admet-2988	434	1	[	[	X
admet-2988	434	2	27	27	NUM
admet-2988	434	3	]	]	X
admet-2988	434	4	r.	r.	PROPN
admet-2988	434	5	pandit	pandit	PROPN
admet-2988	434	6	,	,	PUNCT
admet-2988	434	7	l.	l.	PROPN
admet-2988	434	8	chen	chen	PROPN
admet-2988	434	9	,	,	PUNCT
admet-2988	434	10	j.	j.	PROPN
admet-2988	434	11	götz	götz	PROPN
admet-2988	434	12	.	.	PUNCT
admet-2988	435	1	the	the	DET
admet-2988	435	2	blood	blood	NOUN
admet-2988	435	3	-	-	PUNCT
admet-2988	435	4	brain	brain	NOUN
admet-2988	435	5	barrier	barrier	NOUN
admet-2988	435	6	:	:	PUNCT
admet-2988	435	7	physiology	physiology	NOUN
admet-2988	435	8	and	and	CCONJ
admet-2988	435	9	strategies	strategy	NOUN
admet-2988	435	10	for	for	ADP
admet-2988	435	11	drug	drug	NOUN
admet-2988	435	12	delivery	delivery	NOUN
admet-2988	435	13	.	.	PUNCT
admet-2988	436	1	advanced	advanced	ADJ
admet-2988	436	2	drug	drug	NOUN
admet-2988	436	3	delivery	delivery	NOUN
admet-2988	436	4	reviews	review	VERB
admet-2988	436	5	165	165	NUM
admet-2988	436	6	-	-	SYM
admet-2988	436	7	166	166	NUM
admet-2988	436	8	(	(	PUNCT
admet-2988	436	9	2020	2020	NUM
admet-2988	436	10	)	)	PUNCT
admet-2988	436	11	1	1	NUM
admet-2988	436	12	-	-	SYM
admet-2988	436	13	14	14	NUM
admet-2988	436	14	.	.	PUNCT
admet-2988	437	1	https://doi.org/10.1016/j.addr.2019.11.009	https://doi.org/10.1016/j.addr.2019.11.009	NUM
admet-2988	437	2	[	[	X
admet-2988	437	3	28	28	NUM
admet-2988	437	4	]	]	X
admet-2988	437	5	g.	g.	PROPN
admet-2988	437	6	tosi	tosi	PROPN
admet-2988	437	7	,	,	PUNCT
admet-2988	437	8	j.t	j.t	PROPN
admet-2988	437	9	.	.	PROPN
admet-2988	437	10	duskey	duskey	PROPN
admet-2988	437	11	,	,	PUNCT
admet-2988	437	12	j.	j.	PROPN
admet-2988	437	13	kreuter	kreuter	PROPN
admet-2988	437	14	.	.	PUNCT
admet-2988	438	1	nanoparticles	nanoparticle	NOUN
admet-2988	438	2	as	as	ADP
admet-2988	438	3	carriers	carrier	NOUN
admet-2988	438	4	for	for	ADP
admet-2988	438	5	drug	drug	NOUN
admet-2988	438	6	delivery	delivery	NOUN
admet-2988	438	7	of	of	ADP
admet-2988	438	8	macromolecules	macromolecule	NOUN
admet-2988	438	9	across	across	ADP
admet-2988	438	10	the	the	DET
admet-2988	438	11	blood	blood	NOUN
admet-2988	438	12	-	-	PUNCT
admet-2988	438	13	brain	brain	NOUN
admet-2988	438	14	barrier	barrier	NOUN
admet-2988	438	15	.	.	PUNCT
admet-2988	439	1	expert	expert	ADJ
admet-2988	439	2	opinion	opinion	NOUN
admet-2988	439	3	on	on	ADP
admet-2988	439	4	drug	drug	NOUN
admet-2988	439	5	delivery	delivery	NOUN
admet-2988	439	6	17	17	NUM
admet-2988	439	7	(	(	PUNCT
admet-2988	439	8	2019	2019	NUM
admet-2988	439	9	)	)	PUNCT
admet-2988	439	10	23	23	NUM
admet-2988	439	11	-	-	SYM
admet-2988	439	12	32	32	NUM
admet-2988	439	13	.	.	PUNCT
admet-2988	440	1	https://doi.org/10.1080/17425247.2020.1698544	https://doi.org/10.1080/17425247.2020.1698544	X
admet-2988	441	1	[	[	X
admet-2988	441	2	29	29	NUM
admet-2988	441	3	]	]	X
admet-2988	441	4	s.	s.	PROPN
admet-2988	441	5	ding	ding	PROPN
admet-2988	441	6	,	,	PUNCT
admet-2988	441	7	a.i	a.i	PROPN
admet-2988	441	8	.	.	PROPN
admet-2988	441	9	khan	khan	PROPN
admet-2988	441	10	,	,	PUNCT
admet-2988	441	11	x.	x.	PROPN
admet-2988	441	12	cai	cai	PROPN
admet-2988	441	13	,	,	PUNCT
admet-2988	441	14	y.	y.	PROPN
admet-2988	441	15	song	song	PROPN
admet-2988	441	16	,	,	PUNCT
admet-2988	441	17	z.	z.	PROPN
admet-2988	441	18	lyu	lyu	PROPN
admet-2988	441	19	,	,	PUNCT
admet-2988	441	20	d.	d.	PROPN
admet-2988	441	21	du	du	PROPN
admet-2988	441	22	,	,	PUNCT
admet-2988	441	23	p.	p.	PROPN
admet-2988	441	24	dutta	dutta	PROPN
admet-2988	441	25	,	,	PUNCT
admet-2988	441	26	y.	y.	PROPN
admet-2988	441	27	lin	lin	PROPN
admet-2988	441	28	.	.	PUNCT
admet-2988	442	1	overcoming	overcome	VERB
admet-2988	442	2	blood	blood	NOUN
admet-2988	442	3	-	-	PUNCT
admet-2988	442	4	brain	brain	NOUN
admet-2988	442	5	barrier	barrier	NOUN
admet-2988	442	6	transport	transport	NOUN
admet-2988	442	7	:	:	PUNCT
admet-2988	442	8	advances	advance	NOUN
admet-2988	442	9	in	in	ADP
admet-2988	442	10	nanoparticle	nanoparticle	NOUN
admet-2988	442	11	-	-	PUNCT
admet-2988	442	12	based	base	VERB
admet-2988	442	13	drug	drug	NOUN
admet-2988	442	14	delivery	delivery	NOUN
admet-2988	442	15	strategies	strategy	NOUN
admet-2988	442	16	.	.	PUNCT
admet-2988	443	1	materials	material	NOUN
admet-2988	443	2	today	today	NOUN
admet-2988	443	3	37	37	NUM
admet-2988	443	4	(	(	PUNCT
admet-2988	443	5	2020	2020	NUM
admet-2988	443	6	)	)	PUNCT
admet-2988	443	7	112125	112125	NUM
admet-2988	443	8	.	.	PUNCT
admet-2988	444	1	https://doi.org/10.1016/j.mattod.2020.02.001	https://doi.org/10.1016/j.mattod.2020.02.001	PROPN
admet-2988	444	2	[	[	X
admet-2988	444	3	30	30	NUM
admet-2988	444	4	]	]	PUNCT
admet-2988	444	5	q.	q.	NOUN
admet-2988	445	1	he	he	PRON
admet-2988	445	2	,	,	PUNCT
admet-2988	445	3	j.	j.	PROPN
admet-2988	445	4	liu	liu	PROPN
admet-2988	445	5	,	,	PUNCT
admet-2988	445	6	j.	j.	PROPN
admet-2988	445	7	liang	liang	PROPN
admet-2988	445	8	,	,	PUNCT
admet-2988	445	9	x.	x.	PROPN
admet-2988	445	10	liu	liu	PROPN
admet-2988	445	11	,	,	PUNCT
admet-2988	445	12	w.	w.	PROPN
admet-2988	445	13	li	li	PROPN
admet-2988	445	14	,	,	PUNCT
admet-2988	445	15	z.	z.	PROPN
admet-2988	445	16	liu	liu	PROPN
admet-2988	445	17	,	,	PUNCT
admet-2988	445	18	z.	z.	PROPN
admet-2988	445	19	ding	ding	PROPN
admet-2988	445	20	,	,	PUNCT
admet-2988	445	21	d.	d.	PROPN
admet-2988	445	22	tuo	tuo	PROPN
admet-2988	445	23	.	.	PUNCT
admet-2988	446	1	towards	towards	ADP
admet-2988	446	2	improvements	improvement	NOUN
admet-2988	446	3	for	for	ADP
admet-2988	446	4	penetrating	penetrate	VERB
admet-2988	446	5	the	the	DET
admet-2988	446	6	blood	blood	NOUN
admet-2988	446	7	-	-	PUNCT
admet-2988	446	8	brain	brain	NOUN
admet-2988	446	9	barrier	barrier	NOUN
admet-2988	446	10	—	—	PUNCT
admet-2988	446	11	recent	recent	ADJ
admet-2988	446	12	progress	progress	NOUN
admet-2988	446	13	from	from	ADP
admet-2988	446	14	a	a	DET
admet-2988	446	15	material	material	NOUN
admet-2988	446	16	and	and	CCONJ
admet-2988	446	17	pharmaceutical	pharmaceutical	NOUN
admet-2988	446	18	perspective	perspective	NOUN
admet-2988	446	19	.	.	PUNCT
admet-2988	447	1	cells	cell	NOUN
admet-2988	447	2	7	7	NUM
admet-2988	447	3	(	(	PUNCT
admet-2988	447	4	2018	2018	NUM
admet-2988	447	5	)	)	PUNCT
admet-2988	447	6	24	24	NUM
admet-2988	447	7	https://doi.org/10.3390/cells7040024	https://doi.org/10.3390/cells7040024	NOUN
admet-2988	447	8	[	[	X
admet-2988	447	9	31	31	NUM
admet-2988	447	10	]	]	X
admet-2988	447	11	j.j	j.j	PROPN
admet-2988	447	12	.	.	PROPN
admet-2988	447	13	lochhead	lochhead	PROPN
admet-2988	447	14	,	,	PUNCT
admet-2988	447	15	j.	j.	PROPN
admet-2988	447	16	yang	yang	PROPN
admet-2988	447	17	,	,	PUNCT
admet-2988	447	18	p.t	p.t	PROPN
admet-2988	447	19	.	.	PROPN
admet-2988	447	20	ronaldson	ronaldson	PROPN
admet-2988	447	21	,	,	PUNCT
admet-2988	447	22	t.p	t.p	PROPN
admet-2988	447	23	.	.	PROPN
admet-2988	447	24	davis	davis	PROPN
admet-2988	447	25	.	.	PUNCT
admet-2988	448	1	structure	structure	NOUN
admet-2988	448	2	,	,	PUNCT
admet-2988	448	3	function	function	NOUN
admet-2988	448	4	,	,	PUNCT
admet-2988	448	5	and	and	CCONJ
admet-2988	448	6	regulation	regulation	NOUN
admet-2988	448	7	of	of	ADP
admet-2988	448	8	the	the	DET
admet-2988	448	9	bloodbrain	bloodbrain	NOUN
admet-2988	448	10	barrier	barrier	NOUN
admet-2988	448	11	tight	tight	ADJ
admet-2988	448	12	junction	junction	NOUN
admet-2988	448	13	in	in	ADP
admet-2988	448	14	central	central	ADJ
admet-2988	448	15	nervous	nervous	ADJ
admet-2988	448	16	system	system	NOUN
admet-2988	448	17	disorders	disorder	NOUN
admet-2988	448	18	.	.	PUNCT
admet-2988	449	1	frontiers	frontier	NOUN
admet-2988	449	2	in	in	ADP
admet-2988	449	3	physiology	physiology	NOUN
admet-2988	449	4	11	11	NUM
admet-2988	449	5	(	(	PUNCT
admet-2988	449	6	2020	2020	NUM
admet-2988	449	7	)	)	PUNCT
admet-2988	449	8	914	914	NUM
admet-2988	449	9	.	.	PUNCT
admet-2988	450	1	https://doi.org/10.3389/fphys.2020.00914	https://doi.org/10.3389/fphys.2020.00914	PROPN
admet-2988	451	1	[	[	X
admet-2988	451	2	32	32	NUM
admet-2988	451	3	]	]	X
admet-2988	451	4	c.p	c.p	PROPN
admet-2988	451	5	.	.	PROPN
admet-2988	451	6	profaci	profaci	PROPN
admet-2988	451	7	,	,	PUNCT
admet-2988	451	8	r.n	r.n	PROPN
admet-2988	451	9	.	.	PROPN
admet-2988	451	10	munji	munji	PROPN
admet-2988	451	11	,	,	PUNCT
admet-2988	451	12	r.s	r.s	PROPN
admet-2988	451	13	.	.	PROPN
admet-2988	451	14	pulido	pulido	PROPN
admet-2988	451	15	,	,	PUNCT
admet-2988	451	16	r.	r.	PROPN
admet-2988	451	17	daneman	daneman	PROPN
admet-2988	451	18	.	.	PUNCT
admet-2988	452	1	the	the	DET
admet-2988	452	2	blood	blood	NOUN
admet-2988	452	3	-	-	PUNCT
admet-2988	452	4	brain	brain	NOUN
admet-2988	452	5	barrier	barrier	NOUN
admet-2988	452	6	in	in	ADP
admet-2988	452	7	health	health	NOUN
admet-2988	452	8	and	and	CCONJ
admet-2988	452	9	disease	disease	NOUN
admet-2988	452	10	:	:	PUNCT
admet-2988	452	11	important	important	ADJ
admet-2988	452	12	unanswered	unanswered	ADJ
admet-2988	452	13	questions	question	NOUN
admet-2988	452	14	.	.	PUNCT
admet-2988	453	1	journal	journal	NOUN
admet-2988	453	2	of	of	ADP
admet-2988	453	3	experimental	experimental	ADJ
admet-2988	453	4	medicine	medicine	NOUN
admet-2988	453	5	217(4	217(4	NUM
admet-2988	453	6	)	)	PUNCT
admet-2988	453	7	(	(	PUNCT
admet-2988	453	8	2020	2020	NUM
admet-2988	453	9	)	)	PUNCT
admet-2988	453	10	e20190062	e20190062	PROPN
admet-2988	453	11	.	.	PUNCT
admet-2988	454	1	https://doi.org/10.1084/jem.20190062	https://doi.org/10.1084/jem.20190062	PROPN
admet-2988	454	2	[	[	X
admet-2988	454	3	33	33	NUM
admet-2988	454	4	]	]	PUNCT
admet-2988	454	5	s.	s.	PROPN
admet-2988	454	6	harilal	harilal	PROPN
admet-2988	454	7	,	,	PUNCT
admet-2988	454	8	j.	j.	PROPN
admet-2988	454	9	jose	jose	PROPN
admet-2988	454	10	,	,	PUNCT
admet-2988	454	11	d.g.t	d.g.t	NOUN
admet-2988	454	12	.	.	PUNCT
admet-2988	454	13	parambi	parambi	PROPN
admet-2988	454	14	,	,	PUNCT
admet-2988	454	15	r.	r.	PROPN
admet-2988	454	16	kumar	kumar	PROPN
admet-2988	454	17	,	,	PUNCT
admet-2988	454	18	m.k	m.k	PROPN
admet-2988	454	19	.	.	PROPN
admet-2988	454	20	unnikrishnan	unnikrishnan	PROPN
admet-2988	454	21	,	,	PUNCT
admet-2988	454	22	m.s	m.s	PROPN
admet-2988	454	23	.	.	PUNCT
admet-2988	455	1	uddin	uddin	PROPN
admet-2988	455	2	,	,	PUNCT
admet-2988	455	3	g.e	g.e	PROPN
admet-2988	455	4	.	.	PROPN
admet-2988	455	5	mathew	mathew	PROPN
admet-2988	455	6	,	,	PUNCT
admet-2988	455	7	r.	r.	PROPN
admet-2988	455	8	pratap	pratap	PROPN
admet-2988	455	9	,	,	PUNCT
admet-2988	455	10	a.	a.	NOUN
admet-2988	455	11	marathakam	marathakam	PROPN
admet-2988	455	12	,	,	PUNCT
admet-2988	455	13	b.	b.	PROPN
admet-2988	455	14	mathew	mathew	PROPN
admet-2988	455	15	.	.	PUNCT
admet-2988	456	1	revisiting	revisit	VERB
admet-2988	456	2	the	the	DET
admet-2988	456	3	blood	blood	NOUN
admet-2988	456	4	-	-	PUNCT
admet-2988	456	5	brain	brain	NOUN
admet-2988	456	6	barrier	barrier	NOUN
admet-2988	456	7	:	:	PUNCT
admet-2988	456	8	a	a	DET
admet-2988	456	9	hard	hard	ADJ
admet-2988	456	10	nut	nut	NOUN
admet-2988	456	11	to	to	PART
admet-2988	456	12	crack	crack	VERB
admet-2988	456	13	in	in	ADP
admet-2988	456	14	the	the	DET
admet-2988	456	15	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	ADJ
admet-2988	456	16	https://doi.org/10.1016/j.neuron.2017.07.030	https://doi.org/10.1016/j.neuron.2017.07.030	NUM
admet-2988	456	17	https://doi.org/10.1016/j.ijpharm.2024.124686	https://doi.org/10.1016/j.ijpharm.2024.124686	ADJ
admet-2988	456	18	https://doi.org/10.1016/j.jddst.2023.104694	https://doi.org/10.1016/j.jddst.2023.104694	PROPN
admet-2988	456	19	https://doi.org/10.1016/j.jconrel.2020.11.021	https://doi.org/10.1016/j.jconrel.2020.11.021	PROPN
admet-2988	456	20	https://doi.org/10.1021/acsomega.0c01592	https://doi.org/10.1021/acsomega.0c01592	PROPN
admet-2988	456	21	https://doi.org/10.1016/j.bbamem.2008.10.022	https://doi.org/10.1016/j.bbamem.2008.10.022	PROPN
admet-2988	456	22	https://doi.org/10.1016/j.nbd.2009.07.030	https://doi.org/10.1016/j.nbd.2009.07.030	PROPN
admet-2988	456	23	https://doi.org/10.1021/acs.molpharmaceut.4c00604	https://doi.org/10.1021/acs.molpharmaceut.4c00604	ADP
admet-2988	456	24	https://doi.org/10.1007/s11033-020-05361-2	https://doi.org/10.1007/s11033-020-05361-2	PROPN
admet-2988	456	25	https://doi.org/10.1016/j.addr.2019.11.009	https://doi.org/10.1016/j.addr.2019.11.009	NUM
admet-2988	456	26	https://doi.org/10.1080/17425247.2020.1698544	https://doi.org/10.1080/17425247.2020.1698544	PROPN
admet-2988	457	1	https://doi.org/10.1016/j.mattod.2020.02.001	https://doi.org/10.1016/j.mattod.2020.02.001	PROPN
admet-2988	457	2	https://doi.org/10.3390/cells7040024	https://doi.org/10.3390/cells7040024	NOUN
admet-2988	457	3	https://doi.org/10.3389/fphys.2020.00914	https://doi.org/10.3389/fphys.2020.00914	PROPN
admet-2988	457	4	https://doi.org/10.1084/jem.20190062	https://doi.org/10.1084/jem.20190062	PROPN
admet-2988	457	5	r.	r.	PROPN
admet-2988	457	6	vargas	vargas	PROPN
admet-2988	457	7	et	et	PROPN
admet-2988	457	8	al	al	PROPN
admet-2988	457	9	.	.	PROPN
admet-2988	457	10	admet	admet	PROPN
admet-2988	457	11	&	&	CCONJ
admet-2988	457	12	dmpk	dmpk	PROPN
admet-2988	457	13	13(5	13(5	NUM
admet-2988	457	14	)	)	PUNCT
admet-2988	457	15	(	(	PUNCT
admet-2988	457	16	2025	2025	NUM
admet-2988	457	17	)	)	PUNCT
admet-2988	457	18	2988	2988	NUM
admet-2988	457	19	18	18	NUM
admet-2988	457	20	transportation	transportation	NOUN
admet-2988	457	21	of	of	ADP
admet-2988	457	22	drug	drug	NOUN
admet-2988	457	23	molecules	molecule	NOUN
admet-2988	457	24	.	.	PUNCT
admet-2988	458	1	brain	brain	NOUN
admet-2988	458	2	research	research	PROPN
admet-2988	458	3	bulletin	bulletin	NOUN
admet-2988	458	4	160	160	NUM
admet-2988	458	5	(	(	PUNCT
admet-2988	458	6	2020	2020	NUM
admet-2988	458	7	)	)	PUNCT
admet-2988	458	8	121	121	NUM
admet-2988	458	9	-	-	SYM
admet-2988	458	10	140	140	NUM
admet-2988	458	11	.	.	PUNCT
admet-2988	459	1	https://doi.org/10.1016/j.brainresbull.2020.03.018	https://doi.org/10.1016/j.brainresbull.2020.03.018	NOUN
admet-2988	459	2	[	[	X
admet-2988	459	3	34	34	NUM
admet-2988	459	4	]	]	X
admet-2988	459	5	y.	y.	PROPN
admet-2988	459	6	zhao	zhao	PROPN
admet-2988	459	7	,	,	PUNCT
admet-2988	459	8	l.	l.	PROPN
admet-2988	459	9	gan	gan	PROPN
admet-2988	459	10	,	,	PUNCT
admet-2988	459	11	l.	l.	PROPN
admet-2988	459	12	ren	ren	PROPN
admet-2988	459	13	,	,	PUNCT
admet-2988	459	14	y.	y.	PROPN
admet-2988	459	15	lin	lin	PROPN
admet-2988	459	16	,	,	PUNCT
admet-2988	459	17	c.	c.	PROPN
admet-2988	459	18	ma	ma	PROPN
admet-2988	459	19	,	,	PUNCT
admet-2988	459	20	x.	x.	PROPN
admet-2988	459	21	lin	lin	PROPN
admet-2988	459	22	.	.	PUNCT
admet-2988	460	1	factors	factor	NOUN
admet-2988	460	2	influencing	influence	VERB
admet-2988	460	3	the	the	DET
admet-2988	460	4	blood	blood	NOUN
admet-2988	460	5	-	-	PUNCT
admet-2988	460	6	brain	brain	NOUN
admet-2988	460	7	barrier	barrier	NOUN
admet-2988	460	8	permeability	permeability	NOUN
admet-2988	460	9	.	.	PUNCT
admet-2988	461	1	brain	brain	NOUN
admet-2988	461	2	research	research	PROPN
admet-2988	461	3	1788	1788	NUM
admet-2988	461	4	(	(	PUNCT
admet-2988	461	5	2022	2022	NUM
admet-2988	461	6	)	)	PUNCT
admet-2988	461	7	147397	147397	NUM
admet-2988	461	8	.	.	PUNCT
admet-2988	462	1	https://doi.org/10.1016/j.brainres.2022.147937	https://doi.org/10.1016/j.brainres.2022.147937	PROPN
admet-2988	462	2	[	[	X
admet-2988	462	3	35	35	NUM
admet-2988	462	4	]	]	X
admet-2988	462	5	f.	f.	PROPN
admet-2988	462	6	medina	medina	PROPN
admet-2988	462	7	-	-	PUNCT
admet-2988	462	8	flores	flores	PROPN
admet-2988	462	9	,	,	PUNCT
admet-2988	462	10	g.	g.	PROPN
admet-2988	462	11	hurtado	hurtado	PROPN
admet-2988	462	12	-	-	PUNCT
admet-2988	462	13	alvarado	alvarado	PROPN
admet-2988	462	14	,	,	PUNCT
admet-2988	462	15	a.	a.	PROPN
admet-2988	462	16	contis	contis	PROPN
admet-2988	462	17	-	-	PUNCT
admet-2988	462	18	montes	montes	X
admet-2988	462	19	de	de	X
admet-2988	462	20	oca	oca	PROPN
admet-2988	462	21	,	,	PUNCT
admet-2988	462	22	s.p	s.p	PROPN
admet-2988	462	23	.	.	PUNCT
admet-2988	462	24	lópez	lópez	PROPN
admet-2988	462	25	-	-	PUNCT
admet-2988	462	26	cervantes	cervante	NOUN
admet-2988	462	27	,	,	PUNCT
admet-2988	462	28	m.	m.	NOUN
admet-2988	462	29	konigsberg	konigsberg	PROPN
admet-2988	462	30	,	,	PUNCT
admet-2988	462	31	m.a	m.a	PROPN
admet-2988	462	32	.	.	PROPN
admet-2988	462	33	deli	deli	PROPN
admet-2988	462	34	,	,	PUNCT
admet-2988	462	35	b.	b.	PROPN
admet-2988	462	36	gómez	gómez	PROPN
admet-2988	462	37	-	-	PUNCT
admet-2988	462	38	gonzález	gonzález	PROPN
admet-2988	462	39	.	.	PUNCT
admet-2988	463	1	sleep	sleep	VERB
admet-2988	463	2	loss	loss	NOUN
admet-2988	463	3	disrupts	disrupt	VERB
admet-2988	463	4	pericyte	pericyte	NOUN
admet-2988	463	5	-	-	PUNCT
admet-2988	463	6	brain	brain	NOUN
admet-2988	463	7	endothelial	endothelial	ADJ
admet-2988	463	8	cell	cell	NOUN
admet-2988	463	9	interactions	interaction	NOUN
admet-2988	463	10	impairing	impair	VERB
admet-2988	463	11	blood	blood	NOUN
admet-2988	463	12	-	-	PUNCT
admet-2988	463	13	brain	brain	NOUN
admet-2988	463	14	barrier	barrier	NOUN
admet-2988	463	15	function	function	NOUN
admet-2988	463	16	.	.	PUNCT
admet-2988	464	1	brain	brain	NOUN
admet-2988	464	2	,	,	PUNCT
admet-2988	464	3	behavior	behavior	NOUN
admet-2988	464	4	,	,	PUNCT
admet-2988	464	5	and	and	CCONJ
admet-2988	464	6	immunity	immunity	NOUN
admet-2988	464	7	89	89	NUM
admet-2988	464	8	(	(	PUNCT
admet-2988	464	9	2020	2020	NUM
admet-2988	464	10	)	)	PUNCT
admet-2988	464	11	118132	118132	NUM
admet-2988	464	12	.	.	PUNCT
admet-2988	465	1	https://doi.org/10.1016/j.bbi.2020.05.077	https://doi.org/10.1016/j.bbi.2020.05.077	PROPN
admet-2988	466	1	[	[	X
admet-2988	466	2	36	36	NUM
admet-2988	466	3	]	]	PUNCT
admet-2988	466	4	a.	a.	PROPN
admet-2988	466	5	bhattacharya	bhattacharya	PROPN
admet-2988	466	6	,	,	PUNCT
admet-2988	466	7	d.k	d.k	PROPN
admet-2988	466	8	.	.	PROPN
admet-2988	467	1	kaushik	kaushik	PROPN
admet-2988	467	2	,	,	PUNCT
admet-2988	467	3	b.m	b.m	PROPN
admet-2988	467	4	.	.	PROPN
admet-2988	467	5	lozinski	lozinski	PROPN
admet-2988	467	6	,	,	PUNCT
admet-2988	467	7	v.w	v.w	PROPN
admet-2988	467	8	.	.	PROPN
admet-2988	467	9	yong	yong	PROPN
admet-2988	467	10	.	.	PROPN
admet-2988	468	1	beyond	beyond	ADP
admet-2988	468	2	barrier	barrier	NOUN
admet-2988	468	3	functions	function	NOUN
admet-2988	468	4	:	:	PUNCT
admet-2988	468	5	roles	role	NOUN
admet-2988	468	6	of	of	ADP
admet-2988	468	7	pericytes	pericyte	NOUN
admet-2988	468	8	in	in	ADP
admet-2988	468	9	homeostasis	homeostasis	NOUN
admet-2988	468	10	and	and	CCONJ
admet-2988	468	11	regulation	regulation	NOUN
admet-2988	468	12	of	of	ADP
admet-2988	468	13	neuroinflammation	neuroinflammation	NOUN
admet-2988	468	14	.	.	PUNCT
admet-2988	469	1	journal	journal	PROPN
admet-2988	469	2	of	of	ADP
admet-2988	469	3	neuroscience	neuroscience	NOUN
admet-2988	469	4	research	research	NOUN
admet-2988	469	5	98	98	NUM
admet-2988	469	6	(	(	PUNCT
admet-2988	469	7	2020	2020	NUM
admet-2988	469	8	)	)	PUNCT
admet-2988	469	9	2390	2390	NUM
admet-2988	469	10	-	-	SYM
admet-2988	469	11	2405	2405	NUM
admet-2988	469	12	.	.	PUNCT
admet-2988	470	1	https://doi.org/10.1002/jnr.24715	https://doi.org/10.1002/jnr.24715	NOUN
admet-2988	470	2	[	[	PUNCT
admet-2988	470	3	37	37	NUM
admet-2988	470	4	]	]	PUNCT
admet-2988	470	5	m.	m.	NOUN
admet-2988	470	6	pekny	pekny	PROPN
admet-2988	470	7	,	,	PUNCT
admet-2988	470	8	m.	m.	NOUN
admet-2988	470	9	pekna	pekna	PROPN
admet-2988	470	10	,	,	PUNCT
admet-2988	470	11	a.	a.	NOUN
admet-2988	470	12	messing	messing	NOUN
admet-2988	470	13	,	,	PUNCT
admet-2988	470	14	c.	c.	PROPN
admet-2988	470	15	steinhäuser	steinhäuser	PROPN
admet-2988	470	16	,	,	PUNCT
admet-2988	470	17	j.m	j.m	PROPN
admet-2988	470	18	.	.	PROPN
admet-2988	470	19	lee	lee	PROPN
admet-2988	470	20	,	,	PUNCT
admet-2988	470	21	v.	v.	ADP
admet-2988	470	22	parpura	parpura	NOUN
admet-2988	470	23	,	,	PUNCT
admet-2988	470	24	e.m	e.m	PROPN
admet-2988	470	25	.	.	PROPN
admet-2988	470	26	hol	hol	NOUN
admet-2988	470	27	,	,	PUNCT
admet-2988	470	28	m.	m.	NOUN
admet-2988	470	29	v.	v.	ADP
admet-2988	470	30	sofroniew	sofroniew	NOUN
admet-2988	470	31	,	,	PUNCT
admet-2988	470	32	a.	a.	NOUN
admet-2988	470	33	verkhratsky	verkhratsky	NOUN
admet-2988	470	34	.	.	PUNCT
admet-2988	471	1	astrocytes	astrocyte	NOUN
admet-2988	471	2	:	:	PUNCT
admet-2988	471	3	a	a	DET
admet-2988	471	4	central	central	ADJ
admet-2988	471	5	element	element	NOUN
admet-2988	471	6	in	in	ADP
admet-2988	471	7	neurological	neurological	ADJ
admet-2988	471	8	diseases	disease	NOUN
admet-2988	471	9	.	.	PUNCT
admet-2988	472	1	acta	acta	PROPN
admet-2988	472	2	neuropathologica	neuropathologica	PROPN
admet-2988	472	3	131(3	131(3	NUM
admet-2988	472	4	)	)	PUNCT
admet-2988	472	5	(	(	PUNCT
admet-2988	472	6	2015	2015	NUM
admet-2988	472	7	)	)	PUNCT
admet-2988	472	8	323	323	NUM
admet-2988	472	9	-	-	SYM
admet-2988	472	10	345	345	NUM
admet-2988	472	11	.	.	PUNCT
admet-2988	473	1	https://doi.org/10.1007/s00401-015-1513-1	https://doi.org/10.1007/s00401-015-1513-1	ADJ
admet-2988	474	1	[	[	X
admet-2988	474	2	38	38	NUM
admet-2988	474	3	]	]	PUNCT
admet-2988	474	4	a.	a.	NOUN
admet-2988	474	5	verkhratsky	verkhratsky	NOUN
admet-2988	474	6	,	,	PUNCT
admet-2988	474	7	a.	a.	NOUN
admet-2988	474	8	pivoriūnas	pivoriūna	NOUN
admet-2988	474	9	.	.	PUNCT
admet-2988	475	1	astroglia	astroglia	PROPN
admet-2988	475	2	support	support	NOUN
admet-2988	475	3	,	,	PUNCT
admet-2988	475	4	regulate	regulate	VERB
admet-2988	475	5	and	and	CCONJ
admet-2988	475	6	reinforce	reinforce	VERB
admet-2988	475	7	brain	brain	NOUN
admet-2988	475	8	barriers	barrier	NOUN
admet-2988	475	9	.	.	PUNCT
admet-2988	476	1	neurobiology	neurobiology	NOUN
admet-2988	476	2	of	of	ADP
admet-2988	476	3	disease	disease	NOUN
admet-2988	476	4	179	179	NUM
admet-2988	476	5	(	(	PUNCT
admet-2988	476	6	2023	2023	NUM
admet-2988	476	7	)	)	PUNCT
admet-2988	476	8	106054	106054	NUM
admet-2988	476	9	.	.	PUNCT
admet-2988	477	1	https://doi.org/10.1016/j.nbd.2023.106054	https://doi.org/10.1016/j.nbd.2023.106054	PUNCT
admet-2988	478	1	[	[	X
admet-2988	478	2	39	39	NUM
admet-2988	478	3	]	]	X
admet-2988	478	4	b.p	b.p	PROPN
admet-2988	478	5	.	.	PROPN
admet-2988	478	6	heithoff	heithoff	PROPN
admet-2988	478	7	,	,	PUNCT
admet-2988	478	8	k.k	k.k	PROPN
admet-2988	478	9	.	.	PROPN
admet-2988	478	10	george	george	PROPN
admet-2988	478	11	,	,	PUNCT
admet-2988	478	12	a.n	a.n	PROPN
admet-2988	478	13	.	.	PROPN
admet-2988	478	14	phares	phares	PROPN
admet-2988	478	15	,	,	PUNCT
admet-2988	478	16	i.a	i.a	PROPN
admet-2988	478	17	.	.	PROPN
admet-2988	478	18	zuidhoek	zuidhoek	PROPN
admet-2988	478	19	,	,	PUNCT
admet-2988	478	20	c.	c.	PROPN
admet-2988	478	21	munoz	munoz	PROPN
admet-2988	478	22	-	-	PUNCT
admet-2988	478	23	ballester	ballester	PROPN
admet-2988	478	24	,	,	PUNCT
admet-2988	478	25	s.	s.	PROPN
admet-2988	478	26	robel	robel	PROPN
admet-2988	478	27	.	.	PUNCT
admet-2988	479	1	astrocytes	astrocyte	NOUN
admet-2988	479	2	are	be	AUX
admet-2988	479	3	necessary	necessary	ADJ
admet-2988	479	4	for	for	ADP
admet-2988	479	5	blood	blood	NOUN
admet-2988	479	6	-	-	PUNCT
admet-2988	479	7	brain	brain	NOUN
admet-2988	479	8	barrier	barrier	NOUN
admet-2988	479	9	maintenance	maintenance	NOUN
admet-2988	479	10	in	in	ADP
admet-2988	479	11	the	the	DET
admet-2988	479	12	adult	adult	NOUN
admet-2988	479	13	mouse	mouse	NOUN
admet-2988	479	14	brain	brain	NOUN
admet-2988	479	15	.	.	PUNCT
admet-2988	480	1	glia	glia	PROPN
admet-2988	480	2	69	69	NUM
admet-2988	480	3	(	(	PUNCT
admet-2988	480	4	2021	2021	NUM
admet-2988	480	5	)	)	PUNCT
admet-2988	480	6	436	436	NUM
admet-2988	480	7	-	-	SYM
admet-2988	480	8	472	472	NUM
admet-2988	480	9	.	.	PUNCT
admet-2988	481	1	https://doi.org/10.1002/glia.23908	https://doi.org/10.1002/glia.23908	X
admet-2988	482	1	[	[	X
admet-2988	482	2	40	40	NUM
admet-2988	482	3	]	]	X
admet-2988	482	4	r.c	r.c	PROPN
admet-2988	482	5	.	.	PROPN
admet-2988	482	6	janzer	janzer	PROPN
admet-2988	482	7	,	,	PUNCT
admet-2988	482	8	m.c	m.c	PROPN
admet-2988	482	9	.	.	PROPN
admet-2988	482	10	raff	raff	PROPN
admet-2988	482	11	.	.	PUNCT
admet-2988	482	12	astrocytes	astrocyte	NOUN
admet-2988	482	13	induce	induce	VERB
admet-2988	482	14	blood	blood	NOUN
admet-2988	482	15	-	-	PUNCT
admet-2988	482	16	brain	brain	NOUN
admet-2988	482	17	barrier	barrier	NOUN
admet-2988	482	18	properties	property	NOUN
admet-2988	482	19	in	in	ADP
admet-2988	482	20	endothelial	endothelial	ADJ
admet-2988	482	21	cells	cell	NOUN
admet-2988	482	22	.	.	PUNCT
admet-2988	483	1	nature	nature	NOUN
admet-2988	483	2	325	325	NUM
admet-2988	483	3	6101	6101	NUM
admet-2988	483	4	(	(	PUNCT
admet-2988	483	5	1987	1987	NUM
admet-2988	483	6	)	)	PUNCT
admet-2988	483	7	253	253	NUM
admet-2988	483	8	-	-	SYM
admet-2988	483	9	257	257	NUM
admet-2988	483	10	.	.	PUNCT
admet-2988	483	11	https://doi.org/10.1038/325253a0	https://doi.org/10.1038/325253a0	PRON
admet-2988	484	1	[	[	X
admet-2988	484	2	41	41	NUM
admet-2988	484	3	]	]	X
admet-2988	484	4	g.	g.	PROPN
admet-2988	484	5	allt	allt	PROPN
admet-2988	484	6	,	,	PUNCT
admet-2988	484	7	j.g	j.g	PROPN
admet-2988	484	8	.	.	PROPN
admet-2988	484	9	lawrenson	lawrenson	PROPN
admet-2988	484	10	.	.	PUNCT
admet-2988	485	1	the	the	DET
admet-2988	485	2	blood	blood	NOUN
admet-2988	485	3	-	-	PUNCT
admet-2988	485	4	nerve	nerve	NOUN
admet-2988	485	5	barrier	barrier	NOUN
admet-2988	485	6	:	:	PUNCT
admet-2988	485	7	enzymes	enzyme	NOUN
admet-2988	485	8	,	,	PUNCT
admet-2988	485	9	transporters	transporter	NOUN
admet-2988	485	10	and	and	CCONJ
admet-2988	485	11	receptors	receptor	NOUN
admet-2988	485	12	—	—	PUNCT
admet-2988	485	13	a	a	DET
admet-2988	485	14	comparison	comparison	NOUN
admet-2988	485	15	with	with	ADP
admet-2988	485	16	the	the	DET
admet-2988	485	17	blood	blood	NOUN
admet-2988	485	18	-	-	PUNCT
admet-2988	485	19	brain	brain	NOUN
admet-2988	485	20	barrier	barrier	NOUN
admet-2988	485	21	.	.	PUNCT
admet-2988	486	1	brain	brain	NOUN
admet-2988	486	2	research	research	NOUN
admet-2988	486	3	bulletin	bulletin	NOUN
admet-2988	486	4	52	52	NUM
admet-2988	486	5	(	(	PUNCT
admet-2988	486	6	2000	2000	NUM
admet-2988	486	7	)	)	PUNCT
admet-2988	486	8	1	1	NUM
admet-2988	486	9	-	-	SYM
admet-2988	486	10	12	12	NUM
admet-2988	486	11	.	.	PUNCT
admet-2988	487	1	https://doi.org/10.1016/s0361-9230(00)00230-6	https://doi.org/10.1016/s0361-9230(00)00230-6	PROPN
admet-2988	488	1	[	[	X
admet-2988	488	2	42	42	NUM
admet-2988	488	3	]	]	X
admet-2988	488	4	r.c	r.c	PROPN
admet-2988	488	5	.	.	PROPN
admet-2988	488	6	knopp	knopp	PROPN
admet-2988	488	7	,	,	PUNCT
admet-2988	488	8	w.a	w.a	PROPN
admet-2988	488	9	.	.	PROPN
admet-2988	488	10	banks	banks	PROPN
admet-2988	488	11	,	,	PUNCT
admet-2988	488	12	m.a	m.a	PROPN
admet-2988	488	13	.	.	PROPN
admet-2988	488	14	erickson	erickson	PROPN
admet-2988	488	15	.	.	PUNCT
admet-2988	489	1	physical	physical	ADJ
admet-2988	489	2	associations	association	NOUN
admet-2988	489	3	of	of	ADP
admet-2988	489	4	microglia	microglia	NOUN
admet-2988	489	5	and	and	CCONJ
admet-2988	489	6	the	the	DET
admet-2988	489	7	vascular	vascular	ADJ
admet-2988	489	8	bloodbrain	bloodbrain	NOUN
admet-2988	489	9	barrier	barrier	NOUN
admet-2988	489	10	and	and	CCONJ
admet-2988	489	11	their	their	PRON
admet-2988	489	12	importance	importance	NOUN
admet-2988	489	13	in	in	ADP
admet-2988	489	14	development	development	NOUN
admet-2988	489	15	,	,	PUNCT
admet-2988	489	16	health	health	NOUN
admet-2988	489	17	,	,	PUNCT
admet-2988	489	18	and	and	CCONJ
admet-2988	489	19	disease	disease	NOUN
admet-2988	489	20	.	.	PUNCT
admet-2988	490	1	current	current	ADJ
admet-2988	490	2	opinion	opinion	NOUN
admet-2988	490	3	in	in	ADP
admet-2988	490	4	neurobiology	neurobiology	NOUN
admet-2988	490	5	77	77	NUM
admet-2988	490	6	(	(	PUNCT
admet-2988	490	7	2022	2022	NUM
admet-2988	490	8	)	)	PUNCT
admet-2988	490	9	102648	102648	NUM
admet-2988	490	10	.	.	PUNCT
admet-2988	491	1	https://doi.org/10.1016/j.conb.2022.102648	https://doi.org/10.1016/j.conb.2022.102648	PROPN
admet-2988	491	2	[	[	X
admet-2988	491	3	43	43	NUM
admet-2988	491	4	]	]	PUNCT
admet-2988	491	5	a.	a.	NOUN
admet-2988	491	6	alahmari	alahmari	NOUN
admet-2988	491	7	.	.	PUNCT
admet-2988	492	1	blood	blood	NOUN
admet-2988	492	2	-	-	PUNCT
admet-2988	492	3	brain	brain	NOUN
admet-2988	492	4	barrier	barrier	NOUN
admet-2988	492	5	overview	overview	NOUN
admet-2988	492	6	:	:	PUNCT
admet-2988	492	7	structural	structural	ADJ
admet-2988	492	8	and	and	CCONJ
admet-2988	492	9	functional	functional	ADJ
admet-2988	492	10	correlation	correlation	NOUN
admet-2988	492	11	.	.	PUNCT
admet-2988	493	1	neural	neural	ADJ
admet-2988	493	2	plasticity	plasticity	NOUN
admet-2988	493	3	2021	2021	NUM
admet-2988	493	4	(	(	PUNCT
admet-2988	493	5	2021	2021	NUM
admet-2988	493	6	)	)	PUNCT
admet-2988	493	7	6564585	6564585	NUM
admet-2988	493	8	.	.	PUNCT
admet-2988	494	1	https://doi.org/10.1155/2021/6564585	https://doi.org/10.1155/2021/6564585	PROPN
admet-2988	495	1	[	[	X
admet-2988	495	2	44	44	NUM
admet-2988	495	3	]	]	PUNCT
admet-2988	495	4	p.	p.	NOUN
admet-2988	495	5	pintér	pintér	PROPN
admet-2988	495	6	,	,	PUNCT
admet-2988	495	7	a.	a.	PROPN
admet-2988	495	8	alpár	alpár	PROPN
admet-2988	495	9	.	.	PUNCT
admet-2988	496	1	the	the	DET
admet-2988	496	2	role	role	NOUN
admet-2988	496	3	of	of	ADP
admet-2988	496	4	extracellular	extracellular	ADJ
admet-2988	496	5	matrix	matrix	NOUN
admet-2988	496	6	in	in	ADP
admet-2988	496	7	human	human	ADJ
admet-2988	496	8	neurodegenerative	neurodegenerative	ADJ
admet-2988	496	9	diseases	disease	NOUN
admet-2988	496	10	.	.	PUNCT
admet-2988	497	1	international	international	ADJ
admet-2988	497	2	journal	journal	NOUN
admet-2988	497	3	of	of	ADP
admet-2988	497	4	molecular	molecular	ADJ
admet-2988	497	5	sciences	science	NOUN
admet-2988	497	6	23	23	NUM
admet-2988	497	7	(	(	PUNCT
admet-2988	497	8	2022	2022	NUM
admet-2988	497	9	)	)	PUNCT
admet-2988	497	10	11085	11085	NUM
admet-2988	497	11	.	.	PUNCT
admet-2988	498	1	https://doi.org/10.3390/ijms231911085	https://doi.org/10.3390/ijms231911085	VERB
admet-2988	498	2	[	[	X
admet-2988	499	1	45	45	NUM
admet-2988	499	2	]	]	X
admet-2988	499	3	m.s	m.s	PROPN
admet-2988	499	4	.	.	PUNCT
admet-2988	499	5	thomsen	thomsen	PROPN
admet-2988	499	6	,	,	PUNCT
admet-2988	499	7	l.j	l.j	PROPN
admet-2988	499	8	.	.	PROPN
admet-2988	499	9	routhe	routhe	PROPN
admet-2988	499	10	,	,	PUNCT
admet-2988	499	11	t.	t.	PROPN
admet-2988	499	12	moos	moos	PROPN
admet-2988	499	13	.	.	PUNCT
admet-2988	500	1	the	the	DET
admet-2988	500	2	vascular	vascular	ADJ
admet-2988	500	3	basement	basement	NOUN
admet-2988	500	4	membrane	membrane	NOUN
admet-2988	500	5	in	in	ADP
admet-2988	500	6	the	the	DET
admet-2988	500	7	healthy	healthy	ADJ
admet-2988	500	8	and	and	CCONJ
admet-2988	500	9	pathological	pathological	ADJ
admet-2988	500	10	brain	brain	NOUN
admet-2988	500	11	.	.	PUNCT
admet-2988	501	1	journal	journal	PROPN
admet-2988	501	2	of	of	ADP
admet-2988	501	3	cerebral	cerebral	ADJ
admet-2988	501	4	blood	blood	NOUN
admet-2988	501	5	flow	flow	NOUN
admet-2988	501	6	and	and	CCONJ
admet-2988	501	7	metabolism	metabolism	NOUN
admet-2988	501	8	37	37	NUM
admet-2988	501	9	(	(	PUNCT
admet-2988	501	10	2017	2017	NUM
admet-2988	501	11	)	)	PUNCT
admet-2988	501	12	3300	3300	NUM
admet-2988	501	13	-	-	SYM
admet-2988	501	14	3317	3317	NUM
admet-2988	501	15	.	.	PUNCT
admet-2988	502	1	https://doi.org/10.1177/0271678x17722436	https://doi.org/10.1177/0271678x17722436	NOUN
admet-2988	503	1	[	[	X
admet-2988	503	2	46	46	NUM
admet-2988	503	3	]	]	X
admet-2988	503	4	y.	y.	PROPN
admet-2988	503	5	chen	chen	PROPN
admet-2988	503	6	,	,	PUNCT
admet-2988	503	7	l.	l.	PROPN
admet-2988	503	8	liu	liu	PROPN
admet-2988	503	9	.	.	PUNCT
admet-2988	504	1	modern	modern	ADJ
admet-2988	504	2	methods	method	NOUN
admet-2988	504	3	for	for	ADP
admet-2988	504	4	delivery	delivery	NOUN
admet-2988	504	5	of	of	ADP
admet-2988	504	6	drugs	drug	NOUN
admet-2988	504	7	across	across	ADP
admet-2988	504	8	the	the	DET
admet-2988	504	9	blood	blood	NOUN
admet-2988	504	10	-	-	PUNCT
admet-2988	504	11	brain	brain	NOUN
admet-2988	504	12	barrier	barrier	NOUN
admet-2988	504	13	.	.	PUNCT
admet-2988	505	1	advanced	advanced	ADJ
admet-2988	505	2	drug	drug	NOUN
admet-2988	505	3	delivery	delivery	NOUN
admet-2988	505	4	reviews	review	VERB
admet-2988	505	5	64	64	NUM
admet-2988	505	6	(	(	PUNCT
admet-2988	505	7	2012	2012	NUM
admet-2988	505	8	)	)	PUNCT
admet-2988	505	9	640	640	NUM
admet-2988	505	10	-	-	SYM
admet-2988	505	11	665	665	NUM
admet-2988	505	12	.	.	PUNCT
admet-2988	506	1	https://doi.org/10.1016/j.addr.2011.11.010	https://doi.org/10.1016/j.addr.2011.11.010	PROPN
admet-2988	506	2	[	[	X
admet-2988	506	3	47	47	NUM
admet-2988	506	4	]	]	X
admet-2988	506	5	f.	f.	PROPN
admet-2988	506	6	pifferi	pifferi	PROPN
admet-2988	506	7	,	,	PUNCT
admet-2988	506	8	b.	b.	PROPN
admet-2988	506	9	laurent	laurent	PROPN
admet-2988	506	10	,	,	PUNCT
admet-2988	506	11	m.	m.	NOUN
admet-2988	506	12	plourde	plourde	NOUN
admet-2988	506	13	.	.	PUNCT
admet-2988	507	1	lipid	lipid	NOUN
admet-2988	507	2	transport	transport	NOUN
admet-2988	507	3	and	and	CCONJ
admet-2988	507	4	metabolism	metabolism	NOUN
admet-2988	507	5	at	at	ADP
admet-2988	507	6	the	the	DET
admet-2988	507	7	blood	blood	NOUN
admet-2988	507	8	-	-	PUNCT
admet-2988	507	9	brain	brain	NOUN
admet-2988	507	10	interface	interface	NOUN
admet-2988	507	11	:	:	PUNCT
admet-2988	507	12	implications	implication	NOUN
admet-2988	507	13	in	in	ADP
admet-2988	507	14	health	health	NOUN
admet-2988	507	15	and	and	CCONJ
admet-2988	507	16	disease	disease	NOUN
admet-2988	507	17	.	.	PUNCT
admet-2988	508	1	frontiers	frontier	NOUN
admet-2988	508	2	in	in	ADP
admet-2988	508	3	physiology	physiology	NOUN
admet-2988	508	4	12	12	NUM
admet-2988	508	5	(	(	PUNCT
admet-2988	508	6	2021	2021	NUM
admet-2988	508	7	)	)	PUNCT
admet-2988	508	8	645646	645646	NUM
admet-2988	508	9	.	.	PUNCT
admet-2988	509	1	https://doi.org/10.3389/fphys.2021.645646	https://doi.org/10.3389/fphys.2021.645646	NOUN
admet-2988	510	1	[	[	X
admet-2988	510	2	48	48	NUM
admet-2988	510	3	]	]	PUNCT
admet-2988	510	4	e.	e.	PROPN
admet-2988	510	5	mcmullen	mcmullen	PROPN
admet-2988	510	6	,	,	PUNCT
admet-2988	510	7	a.	a.	PROPN
admet-2988	510	8	weiler	weiler	PROPN
admet-2988	510	9	,	,	PUNCT
admet-2988	510	10	h.m	h.m	PROPN
admet-2988	510	11	.	.	PROPN
admet-2988	510	12	becker	becker	PROPN
admet-2988	510	13	,	,	PUNCT
admet-2988	510	14	s.	s.	PROPN
admet-2988	510	15	schirmeier	schirmeier	PROPN
admet-2988	510	16	.	.	PUNCT
admet-2988	511	1	plasticity	plasticity	NOUN
admet-2988	511	2	of	of	ADP
admet-2988	511	3	carbohydrate	carbohydrate	NOUN
admet-2988	511	4	transport	transport	NOUN
admet-2988	511	5	at	at	ADP
admet-2988	511	6	the	the	DET
admet-2988	511	7	blood	blood	NOUN
admet-2988	511	8	-	-	PUNCT
admet-2988	511	9	brain	brain	NOUN
admet-2988	511	10	barrier	barrier	NOUN
admet-2988	511	11	.	.	PUNCT
admet-2988	512	1	frontiers	frontier	NOUN
admet-2988	512	2	in	in	ADP
admet-2988	512	3	behavioral	behavioral	ADJ
admet-2988	512	4	neuroscience	neuroscience	NOUN
admet-2988	512	5	14	14	NUM
admet-2988	512	6	(	(	PUNCT
admet-2988	512	7	2021	2021	NUM
admet-2988	512	8	)	)	PUNCT
admet-2988	512	9	1443912	1443912	NUM
admet-2988	512	10	.	.	PUNCT
admet-2988	513	1	https://doi.org/10.3389/fnbeh.2020.612430	https://doi.org/10.3389/fnbeh.2020.612430	PROPN
admet-2988	513	2	[	[	X
admet-2988	513	3	49	49	NUM
admet-2988	513	4	]	]	PUNCT
admet-2988	513	5	r.	r.	PROPN
admet-2988	513	6	zaragozá	zaragozá	PROPN
admet-2988	513	7	.	.	PUNCT
admet-2988	514	1	transport	transport	NOUN
admet-2988	514	2	of	of	ADP
admet-2988	514	3	amino	amino	ADJ
admet-2988	514	4	acids	acid	NOUN
admet-2988	514	5	across	across	ADP
admet-2988	514	6	the	the	DET
admet-2988	514	7	blood	blood	NOUN
admet-2988	514	8	-	-	PUNCT
admet-2988	514	9	brain	brain	NOUN
admet-2988	514	10	barrier	barrier	NOUN
admet-2988	514	11	.	.	PUNCT
admet-2988	515	1	frontiers	frontier	NOUN
admet-2988	515	2	in	in	ADP
admet-2988	515	3	physiology	physiology	NOUN
admet-2988	515	4	11	11	NUM
admet-2988	515	5	(	(	PUNCT
admet-2988	515	6	2020	2020	NUM
admet-2988	515	7	)	)	PUNCT
admet-2988	515	8	973	973	NUM
admet-2988	515	9	.	.	PUNCT
admet-2988	516	1	https://doi.org/10.3389/fphys.2020.00973	https://doi.org/10.3389/fphys.2020.00973	PROPN
admet-2988	517	1	[	[	X
admet-2988	517	2	50	50	NUM
admet-2988	517	3	]	]	X
admet-2988	517	4	m.a	m.a	PROPN
admet-2988	517	5	.	.	PROPN
admet-2988	517	6	erickson	erickson	PROPN
admet-2988	517	7	,	,	PUNCT
admet-2988	517	8	w.a	w.a	PROPN
admet-2988	517	9	.	.	PROPN
admet-2988	517	10	banks	bank	NOUN
admet-2988	517	11	.	.	PUNCT
admet-2988	518	1	transcellular	transcellular	NOUN
admet-2988	518	2	routes	route	NOUN
admet-2988	518	3	of	of	ADP
admet-2988	518	4	blood	blood	NOUN
admet-2988	518	5	-	-	PUNCT
admet-2988	518	6	brain	brain	NOUN
admet-2988	518	7	barrier	barrier	NOUN
admet-2988	518	8	disruption	disruption	NOUN
admet-2988	518	9	.	.	PUNCT
admet-2988	519	1	experimental	experimental	ADJ
admet-2988	519	2	biology	biology	NOUN
admet-2988	519	3	and	and	CCONJ
admet-2988	519	4	medicine	medicine	NOUN
admet-2988	519	5	247	247	NUM
admet-2988	519	6	(	(	PUNCT
admet-2988	519	7	2022	2022	NUM
admet-2988	519	8	)	)	PUNCT
admet-2988	519	9	788	788	NUM
admet-2988	519	10	-	-	SYM
admet-2988	519	11	796	796	NUM
admet-2988	519	12	.	.	PUNCT
admet-2988	520	1	https://doi.org/10.1177/15353702221080745	https://doi.org/10.1177/15353702221080745	NOUN
admet-2988	521	1	[	[	X
admet-2988	521	2	51	51	NUM
admet-2988	521	3	]	]	PUNCT
admet-2988	521	4	j.	j.	PROPN
admet-2988	521	5	xie	xie	PROPN
admet-2988	521	6	,	,	PUNCT
admet-2988	521	7	z.	z.	PROPN
admet-2988	521	8	shen	shen	PROPN
admet-2988	521	9	,	,	PUNCT
admet-2988	521	10	y.	y.	PROPN
admet-2988	521	11	anraku	anraku	PROPN
admet-2988	521	12	,	,	PUNCT
admet-2988	521	13	k.	k.	PROPN
admet-2988	521	14	kataoka	kataoka	PROPN
admet-2988	521	15	,	,	PUNCT
admet-2988	521	16	x.	x.	PROPN
admet-2988	521	17	chen	chen	PROPN
admet-2988	521	18	.	.	PUNCT
admet-2988	522	1	nanomaterial	nanomaterial	PROPN
admet-2988	522	2	-	-	PUNCT
admet-2988	522	3	based	base	VERB
admet-2988	522	4	blood	blood	NOUN
admet-2988	522	5	-	-	PUNCT
admet-2988	522	6	brain	brain	NOUN
admet-2988	522	7	-	-	PUNCT
admet-2988	522	8	barrier	barrier	NOUN
admet-2988	522	9	(	(	PUNCT
admet-2988	522	10	bbb	bbb	NOUN
admet-2988	522	11	)	)	PUNCT
admet-2988	522	12	crossing	crossing	NOUN
admet-2988	522	13	strategies	strategy	NOUN
admet-2988	522	14	.	.	PUNCT
admet-2988	523	1	biomaterials	biomaterial	NOUN
admet-2988	523	2	224	224	NUM
admet-2988	523	3	(	(	PUNCT
admet-2988	523	4	2019	2019	NUM
admet-2988	523	5	)	)	PUNCT
admet-2988	523	6	119491	119491	NUM
admet-2988	523	7	.	.	PUNCT
admet-2988	524	1	https://doi.org/10.1016/j.biomaterials.2019.119491	https://doi.org/10.1016/j.biomaterials.2019.119491	NOUN
admet-2988	524	2	https://doi.org/10.1016/j.brainresbull.2020.03.018	https://doi.org/10.1016/j.brainresbull.2020.03.018	NOUN
admet-2988	524	3	https://doi.org/10.1016/j.brainres.2022.147937	https://doi.org/10.1016/j.brainres.2022.147937	PROPN
admet-2988	524	4	https://doi.org/10.1016/j.bbi.2020.05.077	https://doi.org/10.1016/j.bbi.2020.05.077	PROPN
admet-2988	524	5	https://doi.org/10.1002/jnr.24715	https://doi.org/10.1002/jnr.24715	PROPN
admet-2988	524	6	https://doi.org/10.1007/s00401-015-1513-1	https://doi.org/10.1007/s00401-015-1513-1	NOUN
admet-2988	524	7	https://doi.org/10.1016/j.nbd.2023.106054	https://doi.org/10.1016/j.nbd.2023.106054	PUNCT
admet-2988	524	8	https://doi.org/10.1002/glia.23908	https://doi.org/10.1002/glia.23908	X
admet-2988	524	9	https://doi.org/10.1038/325253a0	https://doi.org/10.1038/325253a0	PROPN
admet-2988	524	10	https://doi.org/10.1016/s0361-9230(00)00230-6	https://doi.org/10.1016/s0361-9230(00)00230-6	PROPN
admet-2988	524	11	https://doi.org/10.1016/j.conb.2022.102648	https://doi.org/10.1016/j.conb.2022.102648	PROPN
admet-2988	524	12	https://doi.org/10.1155/2021/6564585	https://doi.org/10.1155/2021/6564585	PROPN
admet-2988	524	13	https://doi.org/10.3390/ijms231911085	https://doi.org/10.3390/ijms231911085	VERB
admet-2988	524	14	https://doi.org/10.1177/0271678x17722436	https://doi.org/10.1177/0271678x17722436	PROPN
admet-2988	524	15	https://doi.org/10.1016/j.addr.2011.11.010	https://doi.org/10.1016/j.addr.2011.11.010	PROPN
admet-2988	524	16	https://doi.org/10.3389/fphys.2021.645646	https://doi.org/10.3389/fphys.2021.645646	PROPN
admet-2988	524	17	https://doi.org/10.3389/fnbeh.2020.612430	https://doi.org/10.3389/fnbeh.2020.612430	PROPN
admet-2988	524	18	https://doi.org/10.3389/fphys.2020.00973	https://doi.org/10.3389/fphys.2020.00973	PROPN
admet-2988	524	19	https://doi.org/10.1177/15353702221080745	https://doi.org/10.1177/15353702221080745	ADJ
admet-2988	524	20	https://doi.org/10.1016/j.biomaterials.2019.119491	https://doi.org/10.1016/j.biomaterials.2019.119491	NOUN
admet-2988	524	21	admet	admet	X
admet-2988	524	22	&	&	CCONJ
admet-2988	524	23	dmpk	dmpk	PROPN
admet-2988	524	24	13(5	13(5	NOUN
admet-2988	524	25	)	)	PUNCT
admet-2988	524	26	(	(	PUNCT
admet-2988	524	27	2025	2025	NUM
admet-2988	524	28	)	)	PUNCT
admet-2988	524	29	2988	2988	NUM
admet-2988	524	30	advancing	advance	VERB
admet-2988	524	31	through	through	ADP
admet-2988	524	32	the	the	DET
admet-2988	524	33	blood	blood	NOUN
admet-2988	524	34	-	-	PUNCT
admet-2988	524	35	brain	brain	NOUN
admet-2988	524	36	barrier	barrier	NOUN
admet-2988	524	37	doi	doi	NOUN
admet-2988	524	38	:	:	PUNCT
admet-2988	524	39	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	524	40	19	19	NUM
admet-2988	524	41	[	[	SYM
admet-2988	524	42	52	52	NUM
admet-2988	524	43	]	]	PUNCT
admet-2988	524	44	t.	t.	PROPN
admet-2988	524	45	nitta	nitta	PROPN
admet-2988	524	46	,	,	PUNCT
admet-2988	524	47	m.	m.	NOUN
admet-2988	524	48	hata	hata	PROPN
admet-2988	524	49	,	,	PUNCT
admet-2988	524	50	s.	s.	PROPN
admet-2988	524	51	gotoh	gotoh	PROPN
admet-2988	524	52	,	,	PUNCT
admet-2988	524	53	y.	y.	PROPN
admet-2988	524	54	seo	seo	PROPN
admet-2988	524	55	,	,	PUNCT
admet-2988	524	56	h.	h.	PROPN
admet-2988	524	57	sasaki	sasaki	PROPN
admet-2988	524	58	,	,	PUNCT
admet-2988	524	59	n.	n.	PROPN
admet-2988	524	60	hashimoto	hashimoto	NOUN
admet-2988	524	61	,	,	PUNCT
admet-2988	524	62	m.	m.	NOUN
admet-2988	524	63	furuse	furuse	NOUN
admet-2988	524	64	,	,	PUNCT
admet-2988	524	65	s.	s.	PROPN
admet-2988	524	66	tsukita	tsukita	PROPN
admet-2988	524	67	.	.	PUNCT
admet-2988	525	1	size	size	NOUN
admet-2988	525	2	-	-	PUNCT
admet-2988	525	3	selective	selective	ADJ
admet-2988	525	4	loosening	loosening	NOUN
admet-2988	525	5	of	of	ADP
admet-2988	525	6	the	the	DET
admet-2988	525	7	blood	blood	NOUN
admet-2988	525	8	-	-	PUNCT
admet-2988	525	9	brain	brain	NOUN
admet-2988	525	10	barrier	barrier	NOUN
admet-2988	525	11	in	in	ADP
admet-2988	525	12	claudin-5	claudin-5	NOUN
admet-2988	525	13	-	-	PUNCT
admet-2988	525	14	deficient	deficient	ADJ
admet-2988	525	15	mice	mouse	NOUN
admet-2988	525	16	.	.	PUNCT
admet-2988	526	1	journal	journal	NOUN
admet-2988	526	2	of	of	ADP
admet-2988	526	3	cell	cell	NOUN
admet-2988	526	4	biology	biology	NOUN
admet-2988	526	5	161	161	NUM
admet-2988	526	6	(	(	PUNCT
admet-2988	526	7	2003	2003	NUM
admet-2988	526	8	)	)	PUNCT
admet-2988	526	9	653	653	NUM
admet-2988	526	10	-	-	SYM
admet-2988	526	11	660	660	NUM
admet-2988	526	12	.	.	PUNCT
admet-2988	527	1	https://doi.org/10.1083/jcb.200302070	https://doi.org/10.1083/jcb.200302070	VERB
admet-2988	528	1	[	[	X
admet-2988	528	2	53	53	NUM
admet-2988	528	3	]	]	PUNCT
admet-2988	528	4	j.	j.	PROPN
admet-2988	528	5	rejman	rejman	PROPN
admet-2988	528	6	,	,	PUNCT
admet-2988	528	7	v.	v.	CCONJ
admet-2988	528	8	oberle	oberle	NOUN
admet-2988	528	9	,	,	PUNCT
admet-2988	528	10	i.s	i.s	PROPN
admet-2988	528	11	.	.	PROPN
admet-2988	528	12	zuhorn	zuhorn	PROPN
admet-2988	528	13	,	,	PUNCT
admet-2988	528	14	d.	d.	PROPN
admet-2988	528	15	hoekstra	hoekstra	PROPN
admet-2988	528	16	.	.	PROPN
admet-2988	528	17	size	size	NOUN
admet-2988	528	18	-	-	PUNCT
admet-2988	528	19	dependent	dependent	ADJ
admet-2988	528	20	internalization	internalization	NOUN
admet-2988	528	21	of	of	ADP
admet-2988	528	22	particles	particle	NOUN
admet-2988	528	23	via	via	ADP
admet-2988	528	24	the	the	DET
admet-2988	528	25	pathways	pathway	NOUN
admet-2988	528	26	of	of	ADP
admet-2988	528	27	clathrin	clathrin	NOUN
admet-2988	528	28	-	-	PUNCT
admet-2988	528	29	and	and	CCONJ
admet-2988	528	30	caveolae	caveolae	NOUN
admet-2988	528	31	-	-	PUNCT
admet-2988	528	32	mediated	mediate	VERB
admet-2988	528	33	endocytosis	endocytosis	NOUN
admet-2988	528	34	.	.	PUNCT
admet-2988	529	1	biochem	biochem	PROPN
admet-2988	529	2	j	j	PROPN
admet-2988	529	3	377	377	NUM
admet-2988	529	4	(	(	PUNCT
admet-2988	529	5	2004	2004	NUM
admet-2988	529	6	)	)	PUNCT
admet-2988	529	7	159	159	NUM
admet-2988	529	8	-	-	SYM
admet-2988	529	9	169	169	NUM
admet-2988	529	10	.	.	PUNCT
admet-2988	530	1	https://doi.org/10.1042/bj20031253	https://doi.org/10.1042/bj20031253	PROPN
admet-2988	531	1	[	[	X
admet-2988	531	2	54	54	NUM
admet-2988	531	3	]	]	PUNCT
admet-2988	531	4	k.	k.	PROPN
admet-2988	531	5	kucharz	kucharz	PROPN
admet-2988	531	6	,	,	PUNCT
admet-2988	531	7	n.	n.	PROPN
admet-2988	531	8	kutuzov	kutuzov	PROPN
admet-2988	531	9	,	,	PUNCT
admet-2988	531	10	o.	o.	PROPN
admet-2988	531	11	zhukov	zhukov	PROPN
admet-2988	531	12	,	,	PUNCT
admet-2988	531	13	m.	m.	NOUN
admet-2988	531	14	mathiesen	mathiesen	PROPN
admet-2988	531	15	janiurek	janiurek	PROPN
admet-2988	531	16	,	,	PUNCT
admet-2988	531	17	m.	m.	NOUN
admet-2988	531	18	lauritzen	lauritzen	PROPN
admet-2988	531	19	.	.	PUNCT
admet-2988	531	20	shedding	shed	VERB
admet-2988	531	21	light	light	NOUN
admet-2988	531	22	on	on	ADP
admet-2988	531	23	the	the	DET
admet-2988	531	24	blood	blood	NOUN
admet-2988	531	25	-	-	PUNCT
admet-2988	531	26	brain	brain	NOUN
admet-2988	531	27	barrier	barrier	NOUN
admet-2988	531	28	transport	transport	NOUN
admet-2988	531	29	with	with	ADP
admet-2988	531	30	two	two	NUM
admet-2988	531	31	-	-	PUNCT
admet-2988	531	32	photon	photon	NOUN
admet-2988	531	33	microscopy	microscopy	NOUN
admet-2988	531	34	in	in	ADP
admet-2988	531	35	vivo	vivo	NOUN
admet-2988	531	36	.	.	PUNCT
admet-2988	532	1	pharmaceutical	pharmaceutical	PROPN
admet-2988	532	2	research	research	PROPN
admet-2988	532	3	39(7	39(7	PROPN
admet-2988	532	4	)	)	PUNCT
admet-2988	532	5	(	(	PUNCT
admet-2988	532	6	2022	2022	NUM
admet-2988	532	7	)	)	PUNCT
admet-2988	532	8	1457	1457	NUM
admet-2988	532	9	-	-	SYM
admet-2988	532	10	1468	1468	NUM
admet-2988	532	11	.	.	PUNCT
admet-2988	533	1	https://doi.org/10.1007/s11095-022-03266-2	https://doi.org/10.1007/s11095-022-03266-2	NOUN
admet-2988	534	1	[	[	X
admet-2988	534	2	55	55	NUM
admet-2988	534	3	]	]	X
admet-2988	534	4	l.e	l.e	PROPN
admet-2988	534	5	.	.	PROPN
admet-2988	534	6	ibarra	ibarra	PROPN
admet-2988	534	7	.	.	PUNCT
admet-2988	535	1	cellular	cellular	ADJ
admet-2988	535	2	trojan	trojan	NOUN
admet-2988	535	3	horses	horse	NOUN
admet-2988	535	4	for	for	ADP
admet-2988	535	5	delivery	delivery	NOUN
admet-2988	535	6	of	of	ADP
admet-2988	535	7	nanomedicines	nanomedicine	NOUN
admet-2988	535	8	to	to	PART
admet-2988	535	9	brain	brain	NOUN
admet-2988	535	10	tumors	tumor	NOUN
admet-2988	535	11	:	:	PUNCT
admet-2988	535	12	where	where	SCONJ
admet-2988	535	13	do	do	AUX
admet-2988	535	14	we	we	PRON
admet-2988	535	15	stand	stand	VERB
admet-2988	535	16	and	and	CCONJ
admet-2988	535	17	what	what	PRON
admet-2988	535	18	is	be	AUX
admet-2988	535	19	next	next	ADJ
admet-2988	535	20	?	?	PUNCT
admet-2988	536	1	nanomedicine	nanomedicine	ADJ
admet-2988	536	2	(	(	PUNCT
admet-2988	536	3	lond	lond	ADJ
admet-2988	536	4	)	)	PUNCT
admet-2988	536	5	16(7	16(7	NUM
admet-2988	536	6	)	)	PUNCT
admet-2988	536	7	(	(	PUNCT
admet-2988	536	8	2021	2021	NUM
admet-2988	536	9	)	)	PUNCT
admet-2988	536	10	517	517	NUM
admet-2988	536	11	-	-	SYM
admet-2988	536	12	522	522	NUM
admet-2988	536	13	.	.	PUNCT
admet-2988	536	14	https://doi.org/10.2217/nnm-2021-0034	https://doi.org/10.2217/nnm-2021-0034	NOUN
admet-2988	536	15	[	[	X
admet-2988	536	16	56	56	NUM
admet-2988	536	17	]	]	X
admet-2988	536	18	f.h	f.h	PROPN
admet-2988	536	19	.	.	PROPN
admet-2988	536	20	santiago	santiago	PROPN
admet-2988	536	21	-	-	PUNCT
admet-2988	536	22	tirado	tirado	NOUN
admet-2988	536	23	,	,	PUNCT
admet-2988	536	24	t.l	t.l	PROPN
admet-2988	536	25	.	.	PROPN
admet-2988	536	26	doering	doering	PROPN
admet-2988	536	27	.	.	PUNCT
admet-2988	537	1	false	false	ADJ
admet-2988	537	2	friends	friend	NOUN
admet-2988	537	3	:	:	PUNCT
admet-2988	537	4	phagocytes	phagocyte	NOUN
admet-2988	537	5	as	as	ADP
admet-2988	537	6	trojan	trojan	NOUN
admet-2988	537	7	horses	horse	NOUN
admet-2988	537	8	in	in	ADP
admet-2988	537	9	microbial	microbial	ADJ
admet-2988	537	10	brain	brain	NOUN
admet-2988	537	11	infections	infection	NOUN
admet-2988	537	12	.	.	PUNCT
admet-2988	538	1	plos	plos	PROPN
admet-2988	538	2	pathogens	pathogen	NOUN
admet-2988	538	3	13	13	NUM
admet-2988	538	4	(	(	PUNCT
admet-2988	538	5	2017	2017	NUM
admet-2988	538	6	)	)	PUNCT
admet-2988	538	7	e1006680	e1006680	NOUN
admet-2988	538	8	.	.	PUNCT
admet-2988	539	1	https://doi.org/10.1371/journal.ppat.1006680	https://doi.org/10.1371/journal.ppat.1006680	PROPN
admet-2988	540	1	[	[	X
admet-2988	540	2	57	57	NUM
admet-2988	540	3	]	]	PUNCT
admet-2988	540	4	a.	a.	NOUN
admet-2988	540	5	achar	achar	PROPN
admet-2988	540	6	,	,	PUNCT
admet-2988	540	7	r.	r.	PROPN
admet-2988	540	8	myers	myers	PROPN
admet-2988	540	9	,	,	PUNCT
admet-2988	540	10	c.	c.	PROPN
admet-2988	540	11	ghosh	ghosh	PROPN
admet-2988	540	12	.	.	PUNCT
admet-2988	541	1	drug	drug	NOUN
admet-2988	541	2	delivery	delivery	NOUN
admet-2988	541	3	challenges	challenge	NOUN
admet-2988	541	4	in	in	ADP
admet-2988	541	5	brain	brain	NOUN
admet-2988	541	6	disorders	disorder	NOUN
admet-2988	541	7	across	across	ADP
admet-2988	541	8	the	the	DET
admet-2988	541	9	blood	blood	NOUN
admet-2988	541	10	-	-	PUNCT
admet-2988	541	11	brain	brain	NOUN
admet-2988	541	12	barrier	barrier	NOUN
admet-2988	541	13	:	:	PUNCT
admet-2988	541	14	novel	novel	ADJ
admet-2988	541	15	methods	method	NOUN
admet-2988	541	16	and	and	CCONJ
admet-2988	541	17	future	future	ADJ
admet-2988	541	18	considerations	consideration	NOUN
admet-2988	541	19	for	for	ADP
admet-2988	541	20	improved	improved	ADJ
admet-2988	541	21	therapy	therapy	NOUN
admet-2988	541	22	.	.	PUNCT
admet-2988	542	1	biomedicines	biomedicine	VERB
admet-2988	542	2	9	9	NUM
admet-2988	542	3	(	(	PUNCT
admet-2988	542	4	2021	2021	NUM
admet-2988	542	5	)	)	PUNCT
admet-2988	542	6	1834	1834	NUM
admet-2988	542	7	.	.	PUNCT
admet-2988	543	1	https://doi.org/10.3390/biomedicines9121834	https://doi.org/10.3390/biomedicines9121834	PROPN
admet-2988	544	1	[	[	X
admet-2988	544	2	58	58	NUM
admet-2988	544	3	]	]	PUNCT
admet-2988	544	4	r.	r.	PROPN
admet-2988	544	5	vargas	vargas	PROPN
admet-2988	544	6	,	,	PUNCT
admet-2988	544	7	j.	j.	PROPN
admet-2988	544	8	soley	soley	PROPN
admet-2988	544	9	.	.	PUNCT
admet-2988	545	1	modulación	modulación	PROPN
admet-2988	545	2	alostérica	alostérica	PROPN
admet-2988	545	3	positiva	positiva	PROPN
admet-2988	545	4	selectiva	selectiva	PROPN
admet-2988	545	5	para	para	PROPN
admet-2988	545	6	el	el	PROPN
admet-2988	545	7	receptor	receptor	PROPN
admet-2988	545	8	muscarínico	muscarínico	PROPN
admet-2988	545	9	m1	m1	PROPN
admet-2988	545	10	:	:	PUNCT
admet-2988	545	11	descubrimiento	descubrimiento	PROPN
admet-2988	545	12	y	y	PROPN
admet-2988	545	13	desarrollo	desarrollo	PROPN
admet-2988	545	14	del	del	PROPN
admet-2988	545	15	compuesto	compuesto	PROPN
admet-2988	545	16	vu0486846	vu0486846	PROPN
admet-2988	545	17	y	y	PROPN
admet-2988	545	18	su	su	PROPN
admet-2988	545	19	importancia	importancia	PROPN
admet-2988	545	20	para	para	PROPN
admet-2988	545	21	el	el	PROPN
admet-2988	545	22	desarrollo	desarrollo	PROPN
admet-2988	545	23	terapéutico	terapéutico	ADJ
admet-2988	545	24	tratamientos	tratamientos	NOUN
admet-2988	545	25	para	para	PROPN
admet-2988	545	26	el	el	PROPN
admet-2988	545	27	alzheimer	alzheimer	PROPN
admet-2988	545	28	y	y	PROPN
admet-2988	545	29	la	la	PROPN
admet-2988	545	30	esquizofrenia	esquizofrenia	PROPN
admet-2988	545	31	selective	selective	ADJ
admet-2988	545	32	positive	positive	ADJ
admet-2988	545	33	allosteric	allosteric	NOUN
admet-2988	545	34	.	.	PUNCT
admet-2988	546	1	ars	ar	VERB
admet-2988	546	2	pharmaceutica	pharmaceutica	PROPN
admet-2988	546	3	62(1	62(1	NOUN
admet-2988	546	4	)	)	PUNCT
admet-2988	546	5	(	(	PUNCT
admet-2988	546	6	2021	2021	NUM
admet-2988	546	7	)	)	PUNCT
admet-2988	546	8	90	90	NUM
admet-2988	546	9	-	-	PUNCT
admet-2988	546	10	111	111	NUM
admet-2988	546	11	.	.	PUNCT
admet-2988	547	1	https://revistaseug.ugr.es/index.php/ars/article/view/15704/15568	https://revistaseug.ugr.es/index.php/ars/article/view/15704/15568	PUNCT
admet-2988	548	1	[	[	X
admet-2988	548	2	in	in	ADP
admet-2988	548	3	spanish	spanish	NOUN
admet-2988	548	4	]	]	X
admet-2988	549	1	[	[	X
admet-2988	549	2	59	59	NUM
admet-2988	549	3	]	]	X
admet-2988	549	4	m.m	m.m	PROPN
admet-2988	549	5	.	.	PROPN
admet-2988	549	6	salman	salman	PROPN
admet-2988	549	7	,	,	PUNCT
admet-2988	549	8	z.	z.	PROPN
admet-2988	549	9	al	al	PROPN
admet-2988	549	10	-	-	PUNCT
admet-2988	549	11	obaidi	obaidi	PROPN
admet-2988	549	12	,	,	PUNCT
admet-2988	549	13	p.	p.	NOUN
admet-2988	549	14	kitchen	kitchen	NOUN
admet-2988	549	15	,	,	PUNCT
admet-2988	549	16	a.	a.	PROPN
admet-2988	549	17	loreto	loreto	PROPN
admet-2988	549	18	,	,	PUNCT
admet-2988	549	19	r.m	r.m	PROPN
admet-2988	549	20	.	.	PROPN
admet-2988	549	21	bill	bill	PROPN
admet-2988	549	22	,	,	PUNCT
admet-2988	549	23	r.	r.	PROPN
admet-2988	549	24	wade	wade	PROPN
admet-2988	549	25	-	-	PUNCT
admet-2988	549	26	martins	martins	PROPN
admet-2988	549	27	.	.	PUNCT
admet-2988	550	1	advances	advance	NOUN
admet-2988	550	2	in	in	ADP
admet-2988	550	3	applying	apply	VERB
admet-2988	550	4	computer	computer	NOUN
admet-2988	550	5	-	-	PUNCT
admet-2988	550	6	aided	aid	VERB
admet-2988	550	7	drug	drug	NOUN
admet-2988	550	8	design	design	NOUN
admet-2988	550	9	for	for	ADP
admet-2988	550	10	neurodegenerative	neurodegenerative	ADJ
admet-2988	550	11	diseases	disease	NOUN
admet-2988	550	12	.	.	PUNCT
admet-2988	551	1	international	international	ADJ
admet-2988	551	2	journal	journal	NOUN
admet-2988	551	3	of	of	ADP
admet-2988	551	4	molecular	molecular	ADJ
admet-2988	551	5	sciences	science	NOUN
admet-2988	551	6	22	22	NUM
admet-2988	551	7	(	(	PUNCT
admet-2988	551	8	2021	2021	NUM
admet-2988	551	9	)	)	PUNCT
admet-2988	551	10	4688	4688	NUM
admet-2988	551	11	.	.	PUNCT
admet-2988	552	1	https://doi.org/10.3390/ijms22094688	https://doi.org/10.3390/ijms22094688	NOUN
admet-2988	553	1	[	[	X
admet-2988	553	2	60	60	NUM
admet-2988	553	3	]	]	X
admet-2988	553	4	e.	e.	PROPN
admet-2988	553	5	nance	nance	PROPN
admet-2988	553	6	,	,	PUNCT
admet-2988	553	7	s.h	s.h	PROPN
admet-2988	553	8	.	.	PROPN
admet-2988	553	9	pun	pun	PROPN
admet-2988	553	10	,	,	PUNCT
admet-2988	553	11	r.	r.	PROPN
admet-2988	553	12	saigal	saigal	PROPN
admet-2988	553	13	,	,	PUNCT
admet-2988	553	14	d.l	d.l	PROPN
admet-2988	553	15	.	.	PROPN
admet-2988	553	16	sellers	seller	NOUN
admet-2988	553	17	.	.	PUNCT
admet-2988	554	1	drug	drug	NOUN
admet-2988	554	2	delivery	delivery	NOUN
admet-2988	554	3	to	to	ADP
admet-2988	554	4	the	the	DET
admet-2988	554	5	central	central	ADJ
admet-2988	554	6	nervous	nervous	ADJ
admet-2988	554	7	system	system	NOUN
admet-2988	554	8	.	.	PUNCT
admet-2988	555	1	nature	nature	NOUN
admet-2988	555	2	reviews	review	VERB
admet-2988	555	3	materials	material	NOUN
admet-2988	555	4	7	7	NUM
admet-2988	555	5	(	(	PUNCT
admet-2988	555	6	2021	2021	NUM
admet-2988	555	7	)	)	PUNCT
admet-2988	555	8	314	314	NUM
admet-2988	555	9	-	-	SYM
admet-2988	555	10	331	331	NUM
admet-2988	555	11	.	.	PUNCT
admet-2988	556	1	https://doi.org/10.1038/s41578-021-00394-w	https://doi.org/10.1038/s41578-021-00394-w	PROPN
admet-2988	557	1	[	[	X
admet-2988	557	2	61	61	NUM
admet-2988	557	3	]	]	PUNCT
admet-2988	557	4	h.	h.	PROPN
admet-2988	557	5	wu	wu	PROPN
admet-2988	557	6	,	,	PUNCT
admet-2988	557	7	y.	y.	PROPN
admet-2988	557	8	zhou	zhou	PROPN
admet-2988	557	9	,	,	PUNCT
admet-2988	557	10	y.	y.	PROPN
admet-2988	557	11	wang	wang	PROPN
admet-2988	557	12	,	,	PUNCT
admet-2988	557	13	l.	l.	PROPN
admet-2988	557	14	tong	tong	PROPN
admet-2988	557	15	,	,	PUNCT
admet-2988	557	16	f.	f.	PROPN
admet-2988	557	17	wang	wang	PROPN
admet-2988	557	18	,	,	PUNCT
admet-2988	557	19	s.	s.	PROPN
admet-2988	557	20	song	song	PROPN
admet-2988	557	21	,	,	PUNCT
admet-2988	557	22	l.	l.	PROPN
admet-2988	557	23	xu	xu	PROPN
admet-2988	557	24	,	,	PUNCT
admet-2988	557	25	b.	b.	PROPN
admet-2988	557	26	liu	liu	PROPN
admet-2988	557	27	,	,	PUNCT
admet-2988	557	28	h.	h.	PROPN
admet-2988	557	29	yan	yan	PROPN
admet-2988	557	30	,	,	PUNCT
admet-2988	557	31	z.	z.	PROPN
admet-2988	557	32	sun	sun	PROPN
admet-2988	557	33	.	.	PUNCT
admet-2988	558	1	current	current	ADJ
admet-2988	558	2	state	state	NOUN
admet-2988	558	3	and	and	CCONJ
admet-2988	558	4	future	future	ADJ
admet-2988	558	5	directions	direction	NOUN
admet-2988	558	6	of	of	ADP
admet-2988	558	7	intranasal	intranasal	ADJ
admet-2988	558	8	delivery	delivery	NOUN
admet-2988	558	9	route	route	NOUN
admet-2988	558	10	for	for	ADP
admet-2988	558	11	central	central	ADJ
admet-2988	558	12	nervous	nervous	ADJ
admet-2988	558	13	system	system	NOUN
admet-2988	558	14	disorders	disorder	NOUN
admet-2988	558	15	:	:	PUNCT
admet-2988	558	16	a	a	DET
admet-2988	558	17	scientometric	scientometric	ADJ
admet-2988	558	18	and	and	CCONJ
admet-2988	558	19	visualization	visualization	NOUN
admet-2988	558	20	analysis	analysis	NOUN
admet-2988	558	21	.	.	PUNCT
admet-2988	559	1	frontiers	frontier	NOUN
admet-2988	559	2	in	in	ADP
admet-2988	559	3	pharmacology	pharmacology	NOUN
admet-2988	559	4	12	12	NUM
admet-2988	559	5	(	(	PUNCT
admet-2988	559	6	2021	2021	NUM
admet-2988	559	7	)	)	PUNCT
admet-2988	559	8	717192	717192	NUM
admet-2988	559	9	.	.	PUNCT
admet-2988	560	1	https://doi.org/10.3389/fphar.2021.717192	https://doi.org/10.3389/fphar.2021.717192	PRON
admet-2988	561	1	[	[	X
admet-2988	561	2	62	62	NUM
admet-2988	561	3	]	]	PUNCT
admet-2988	561	4	g.	g.	PROPN
admet-2988	561	5	torrandell	torrandell	NOUN
admet-2988	561	6	-	-	PUNCT
admet-2988	561	7	haro	haro	NOUN
admet-2988	561	8	,	,	PUNCT
admet-2988	561	9	g.l	g.l	PROPN
admet-2988	561	10	.	.	PROPN
admet-2988	561	11	branigan	branigan	PROPN
admet-2988	561	12	,	,	PUNCT
admet-2988	561	13	f.	f.	PROPN
admet-2988	561	14	vitali	vitali	PROPN
admet-2988	561	15	,	,	PUNCT
admet-2988	561	16	n.	n.	PROPN
admet-2988	561	17	geifman	geifman	NOUN
admet-2988	561	18	,	,	PUNCT
admet-2988	561	19	j.m	j.m	PROPN
admet-2988	561	20	.	.	PROPN
admet-2988	561	21	zissimopoulos	zissimopoulos	PROPN
admet-2988	561	22	,	,	PUNCT
admet-2988	561	23	r.d	r.d	PROPN
admet-2988	561	24	.	.	PROPN
admet-2988	561	25	brinton	brinton	PROPN
admet-2988	561	26	.	.	PUNCT
admet-2988	562	1	statin	statin	PROPN
admet-2988	562	2	therapy	therapy	NOUN
admet-2988	562	3	and	and	CCONJ
admet-2988	562	4	risk	risk	NOUN
admet-2988	562	5	of	of	ADP
admet-2988	562	6	alzheimer	alzheimer	PROPN
admet-2988	562	7	’s	’s	PART
admet-2988	562	8	and	and	CCONJ
admet-2988	562	9	age	age	NOUN
admet-2988	562	10	-	-	PUNCT
admet-2988	562	11	related	relate	VERB
admet-2988	562	12	neurodegenerative	neurodegenerative	ADJ
admet-2988	562	13	diseases	disease	NOUN
admet-2988	562	14	.	.	PUNCT
admet-2988	563	1	alzheimer	alzheimer	PROPN
admet-2988	563	2	’s	’s	PART
admet-2988	563	3	&	&	CCONJ
admet-2988	563	4	dementia	dementia	PROPN
admet-2988	563	5	:	:	PUNCT
admet-2988	563	6	translational	translational	ADJ
admet-2988	563	7	research	research	PROPN
admet-2988	563	8	&	&	CCONJ
admet-2988	563	9	clinical	clinical	ADJ
admet-2988	563	10	interventions	intervention	NOUN
admet-2988	563	11	6	6	NUM
admet-2988	563	12	(	(	PUNCT
admet-2988	563	13	2020	2020	NUM
admet-2988	563	14	)	)	PUNCT
admet-2988	563	15	e12108	e12108	PROPN
admet-2988	563	16	.	.	PUNCT
admet-2988	563	17	https://doi.org/10.1002/trc2.12108	https://doi.org/10.1002/trc2.12108	PART
admet-2988	564	1	[	[	X
admet-2988	564	2	63	63	NUM
admet-2988	564	3	]	]	PUNCT
admet-2988	564	4	o.	o.	PROPN
admet-2988	564	5	hansson	hansson	PROPN
admet-2988	564	6	.	.	PUNCT
admet-2988	565	1	biomarkers	biomarker	NOUN
admet-2988	565	2	for	for	ADP
admet-2988	565	3	neurodegenerative	neurodegenerative	ADJ
admet-2988	565	4	diseases	disease	NOUN
admet-2988	565	5	.	.	PUNCT
admet-2988	566	1	nature	nature	NOUN
admet-2988	566	2	medicine	medicine	NOUN
admet-2988	566	3	27	27	NUM
admet-2988	566	4	(	(	PUNCT
admet-2988	566	5	2021	2021	NUM
admet-2988	566	6	)	)	PUNCT
admet-2988	566	7	954	954	NUM
admet-2988	566	8	-	-	SYM
admet-2988	566	9	963	963	NUM
admet-2988	566	10	.	.	PUNCT
admet-2988	567	1	https://doi.org/10.1038/s41591-021-01382-x	https://doi.org/10.1038/s41591-021-01382-x	NOUN
admet-2988	568	1	[	[	X
admet-2988	568	2	64	64	NUM
admet-2988	568	3	]	]	PUNCT
admet-2988	568	4	h.	h.	PROPN
admet-2988	568	5	aldewachi	aldewachi	PROPN
admet-2988	568	6	,	,	PUNCT
admet-2988	568	7	r.n	r.n	PROPN
admet-2988	568	8	.	.	PROPN
admet-2988	568	9	al	al	PROPN
admet-2988	568	10	-	-	PROPN
admet-2988	568	11	zidan	zidan	PROPN
admet-2988	568	12	,	,	PUNCT
admet-2988	568	13	m.t	m.t	PROPN
admet-2988	568	14	.	.	PROPN
admet-2988	568	15	conner	conner	PROPN
admet-2988	568	16	,	,	PUNCT
admet-2988	568	17	m.m	m.m	PROPN
admet-2988	568	18	.	.	PROPN
admet-2988	568	19	salman	salman	PROPN
admet-2988	568	20	.	.	PUNCT
admet-2988	569	1	high	high	ADJ
admet-2988	569	2	-	-	PUNCT
admet-2988	569	3	throughput	throughput	NOUN
admet-2988	569	4	screening	screening	NOUN
admet-2988	569	5	platforms	platform	NOUN
admet-2988	569	6	in	in	ADP
admet-2988	569	7	the	the	DET
admet-2988	569	8	discovery	discovery	NOUN
admet-2988	569	9	of	of	ADP
admet-2988	569	10	novel	novel	ADJ
admet-2988	569	11	drugs	drug	NOUN
admet-2988	569	12	for	for	ADP
admet-2988	569	13	neurodegenerative	neurodegenerative	ADJ
admet-2988	569	14	diseases	disease	NOUN
admet-2988	569	15	.	.	PUNCT
admet-2988	570	1	bioengineering	bioengineere	VERB
admet-2988	570	2	8	8	NUM
admet-2988	570	3	(	(	PUNCT
admet-2988	570	4	2021	2021	NUM
admet-2988	570	5	)	)	PUNCT
admet-2988	570	6	30	30	NUM
admet-2988	570	7	.	.	PUNCT
admet-2988	571	1	https://doi.org/10.3390/bioengineering8020030	https://doi.org/10.3390/bioengineering8020030	PROPN
admet-2988	571	2	[	[	X
admet-2988	571	3	65	65	NUM
admet-2988	571	4	]	]	X
admet-2988	571	5	l.	l.	PROPN
admet-2988	571	6	gamarra	gamarra	PROPN
admet-2988	571	7	,	,	PUNCT
admet-2988	571	8	l.	l.	PROPN
admet-2988	571	9	cláudio	cláudio	PROPN
admet-2988	571	10	,	,	PUNCT
admet-2988	571	11	r.	r.	PROPN
admet-2988	571	12	pereira	pereira	PROPN
admet-2988	571	13	,	,	PUNCT
admet-2988	571	14	d.	d.	PROPN
admet-2988	571	15	silva	silva	PROPN
admet-2988	571	16	,	,	PUNCT
admet-2988	571	17	j.b	j.b	PROPN
admet-2988	571	18	.	.	PROPN
admet-2988	571	19	mamani	mamani	PROPN
admet-2988	571	20	,	,	PUNCT
admet-2988	571	21	s.	s.	PROPN
admet-2988	571	22	bhunia	bhunia	PROPN
admet-2988	571	23	,	,	PUNCT
admet-2988	571	24	n.	n.	PROPN
admet-2988	571	25	kolishetti	kolishetti	PROPN
admet-2988	571	26	,	,	PUNCT
admet-2988	571	27	a.	a.	NOUN
admet-2988	571	28	vashist	vashist	PROPN
admet-2988	571	29	,	,	PUNCT
admet-2988	571	30	a.y	a.y	PROPN
admet-2988	571	31	.	.	PROPN
admet-2988	571	32	arias	arias	PROPN
admet-2988	571	33	,	,	PUNCT
admet-2988	571	34	d.	d.	PROPN
admet-2988	571	35	brooks	brooks	PROPN
admet-2988	571	36	,	,	PUNCT
admet-2988	571	37	m.	m.	NOUN
admet-2988	571	38	nair	nair	PROPN
admet-2988	571	39	.	.	PUNCT
admet-2988	572	1	drug	drug	NOUN
admet-2988	572	2	delivery	delivery	NOUN
admet-2988	572	3	to	to	ADP
admet-2988	572	4	the	the	DET
admet-2988	572	5	brain	brain	NOUN
admet-2988	572	6	:	:	PUNCT
admet-2988	572	7	recent	recent	ADJ
admet-2988	572	8	advances	advance	NOUN
admet-2988	572	9	and	and	CCONJ
admet-2988	572	10	unmet	unmet	NOUN
admet-2988	572	11	challenges	challenge	NOUN
admet-2988	572	12	.	.	PUNCT
admet-2988	573	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	573	2	15	15	NUM
admet-2988	573	3	(	(	PUNCT
admet-2988	573	4	2023	2023	NUM
admet-2988	573	5	)	)	PUNCT
admet-2988	573	6	2658	2658	NUM
admet-2988	573	7	.	.	PUNCT
admet-2988	574	1	https://doi.org/10.3390/pharmaceutics15122658	https://doi.org/10.3390/pharmaceutics15122658	PROPN
admet-2988	575	1	[	[	X
admet-2988	575	2	66	66	NUM
admet-2988	575	3	]	]	X
admet-2988	575	4	r.i	r.i	PROPN
admet-2988	575	5	.	.	PROPN
admet-2988	575	6	teleanu	teleanu	PROPN
admet-2988	575	7	,	,	PUNCT
admet-2988	575	8	m.d	m.d	PROPN
admet-2988	575	9	.	.	PROPN
admet-2988	575	10	preda	preda	PROPN
admet-2988	575	11	,	,	PUNCT
admet-2988	575	12	a.g	a.g	PROPN
admet-2988	575	13	.	.	PROPN
admet-2988	575	14	niculescu	niculescu	PROPN
admet-2988	575	15	,	,	PUNCT
admet-2988	575	16	o.	o.	PROPN
admet-2988	575	17	vladâcenco	vladâcenco	PROPN
admet-2988	575	18	,	,	PUNCT
admet-2988	575	19	c.i	c.i	PROPN
admet-2988	575	20	.	.	PROPN
admet-2988	575	21	radu	radu	PROPN
admet-2988	575	22	,	,	PUNCT
admet-2988	575	23	a.m.	a.m.	PROPN
admet-2988	575	24	grumezescu	grumezescu	PROPN
admet-2988	575	25	,	,	PUNCT
admet-2988	575	26	d.m	d.m	PROPN
admet-2988	575	27	.	.	PROPN
admet-2988	575	28	teleanu	teleanu	PROPN
admet-2988	575	29	.	.	PUNCT
admet-2988	576	1	brain	brain	NOUN
admet-2988	576	2	barrier	barrier	NOUN
admet-2988	576	3	.	.	PUNCT
admet-2988	577	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	577	2	14	14	NUM
admet-2988	577	3	(	(	PUNCT
admet-2988	577	4	2022	2022	NUM
admet-2988	577	5	)	)	PUNCT
admet-2988	577	6	987	987	NUM
admet-2988	577	7	.	.	PUNCT
admet-2988	578	1	https://doi.org/10.3390/pharmaceutics14050987	https://doi.org/10.3390/pharmaceutics14050987	PROPN
admet-2988	578	2	[	[	X
admet-2988	578	3	67	67	NUM
admet-2988	578	4	]	]	X
admet-2988	578	5	b.	b.	PROPN
admet-2988	578	6	sethi	sethi	PROPN
admet-2988	578	7	,	,	PUNCT
admet-2988	578	8	v.	v.	PROPN
admet-2988	578	9	kumar	kumar	PROPN
admet-2988	578	10	,	,	PUNCT
admet-2988	578	11	k.	k.	PROPN
admet-2988	578	12	mahato	mahato	PROPN
admet-2988	578	13	,	,	PUNCT
admet-2988	578	14	d.w	d.w	PROPN
admet-2988	578	15	.	.	PROPN
admet-2988	578	16	coulter	coulter	PROPN
admet-2988	578	17	,	,	PUNCT
admet-2988	578	18	r.i	r.i	PROPN
admet-2988	578	19	.	.	PROPN
admet-2988	578	20	mahato	mahato	PROPN
admet-2988	578	21	.	.	PUNCT
admet-2988	579	1	recent	recent	ADJ
admet-2988	579	2	advances	advance	NOUN
admet-2988	579	3	in	in	ADP
admet-2988	579	4	drug	drug	NOUN
admet-2988	579	5	delivery	delivery	NOUN
admet-2988	579	6	and	and	CCONJ
admet-2988	579	7	targeting	target	VERB
admet-2988	579	8	to	to	ADP
admet-2988	579	9	the	the	DET
admet-2988	579	10	brain	brain	NOUN
admet-2988	579	11	.	.	PUNCT
admet-2988	580	1	journal	journal	PROPN
admet-2988	580	2	of	of	ADP
admet-2988	580	3	controlled	control	VERB
admet-2988	580	4	release	release	NOUN
admet-2988	580	5	350	350	NUM
admet-2988	580	6	(	(	PUNCT
admet-2988	580	7	2022	2022	NUM
admet-2988	580	8	)	)	PUNCT
admet-2988	580	9	668	668	NUM
admet-2988	580	10	-	-	SYM
admet-2988	580	11	687	687	NUM
admet-2988	580	12	.	.	PUNCT
admet-2988	581	1	https://doi.org/10.1016/j.jconrel.2022.08.051	https://doi.org/10.1016/j.jconrel.2022.08.051	PROPN
admet-2988	582	1	[	[	X
admet-2988	582	2	68	68	NUM
admet-2988	582	3	]	]	X
admet-2988	582	4	f.	f.	PROPN
admet-2988	582	5	meng	meng	PROPN
admet-2988	582	6	,	,	PUNCT
admet-2988	582	7	y.	y.	PROPN
admet-2988	582	8	xi	xi	PROPN
admet-2988	582	9	,	,	PUNCT
admet-2988	582	10	j.	j.	PROPN
admet-2988	582	11	huang	huang	PROPN
admet-2988	582	12	,	,	PUNCT
admet-2988	582	13	p.w	p.w	PROPN
admet-2988	582	14	.	.	PUNCT
admet-2988	582	15	ayers	ayers	PROPN
admet-2988	582	16	.	.	PUNCT
admet-2988	583	1	a	a	DET
admet-2988	583	2	curated	curate	VERB
admet-2988	583	3	diverse	diverse	ADJ
admet-2988	583	4	molecular	molecular	ADJ
admet-2988	583	5	database	database	NOUN
admet-2988	583	6	of	of	ADP
admet-2988	583	7	blood	blood	NOUN
admet-2988	583	8	-	-	PUNCT
admet-2988	583	9	brain	brain	NOUN
admet-2988	583	10	barrier	barrier	NOUN
admet-2988	583	11	permeability	permeability	NOUN
admet-2988	583	12	with	with	ADP
admet-2988	583	13	chemical	chemical	ADJ
admet-2988	583	14	descriptors	descriptor	NOUN
admet-2988	583	15	.	.	PUNCT
admet-2988	584	1	scientific	scientific	ADJ
admet-2988	584	2	data	datum	NOUN
admet-2988	584	3	8	8	NUM
admet-2988	584	4	(	(	PUNCT
admet-2988	584	5	2021	2021	NUM
admet-2988	584	6	)	)	PUNCT
admet-2988	584	7	289	289	NUM
admet-2988	584	8	.	.	PUNCT
admet-2988	585	1	https://doi.org/10.1038/s41597-021-01069-5	https://doi.org/10.1038/s41597-021-01069-5	PROPN
admet-2988	585	2	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	PROPN
admet-2988	585	3	https://doi.org/10.1083/jcb.200302070	https://doi.org/10.1083/jcb.200302070	PROPN
admet-2988	585	4	https://doi.org/10.1042/bj20031253	https://doi.org/10.1042/bj20031253	PROPN
admet-2988	585	5	https://doi.org/10.1007/s11095-022-03266-2	https://doi.org/10.1007/s11095-022-03266-2	NOUN
admet-2988	585	6	https://doi.org/10.2217/nnm-2021-0034	https://doi.org/10.2217/nnm-2021-0034	NOUN
admet-2988	585	7	https://doi.org/10.1371/journal.ppat.1006680	https://doi.org/10.1371/journal.ppat.1006680	PROPN
admet-2988	585	8	https://doi.org/10.3390/biomedicines9121834	https://doi.org/10.3390/biomedicines9121834	PROPN
admet-2988	585	9	https://revistaseug.ugr.es/index.php/ars/article/view/15704/15568	https://revistaseug.ugr.es/index.php/ars/article/view/15704/15568	PROPN
admet-2988	585	10	https://doi.org/10.3390/ijms22094688	https://doi.org/10.3390/ijms22094688	NOUN
admet-2988	586	1	https://doi.org/10.1038/s41578-021-00394-w	https://doi.org/10.1038/s41578-021-00394-w	PROPN
admet-2988	586	2	https://doi.org/10.3389/fphar.2021.717192	https://doi.org/10.3389/fphar.2021.717192	PROPN
admet-2988	586	3	https://doi.org/10.1002/trc2.12108	https://doi.org/10.1002/trc2.12108	CCONJ
admet-2988	586	4	https://doi.org/10.1038/s41591-021-01382-x	https://doi.org/10.1038/s41591-021-01382-x	NOUN
admet-2988	586	5	https://doi.org/10.3390/bioengineering8020030	https://doi.org/10.3390/bioengineering8020030	NOUN
admet-2988	586	6	https://doi.org/10.3390/pharmaceutics15122658	https://doi.org/10.3390/pharmaceutics15122658	PROPN
admet-2988	586	7	https://doi.org/10.3390/pharmaceutics14050987	https://doi.org/10.3390/pharmaceutics14050987	PROPN
admet-2988	586	8	https://doi.org/10.1016/j.jconrel.2022.08.051	https://doi.org/10.1016/j.jconrel.2022.08.051	PROPN
admet-2988	587	1	https://doi.org/10.1038/s41597-021-01069-5	https://doi.org/10.1038/s41597-021-01069-5	PROPN
admet-2988	587	2	r.	r.	PROPN
admet-2988	587	3	vargas	vargas	PROPN
admet-2988	587	4	et	et	PROPN
admet-2988	587	5	al	al	PROPN
admet-2988	587	6	.	.	PROPN
admet-2988	587	7	admet	admet	PROPN
admet-2988	587	8	&	&	CCONJ
admet-2988	587	9	dmpk	dmpk	PROPN
admet-2988	587	10	13(5	13(5	NUM
admet-2988	587	11	)	)	PUNCT
admet-2988	587	12	(	(	PUNCT
admet-2988	587	13	2025	2025	NUM
admet-2988	587	14	)	)	PUNCT
admet-2988	587	15	2988	2988	NUM
admet-2988	587	16	20	20	NUM
admet-2988	588	1	[	[	SYM
admet-2988	588	2	69	69	NUM
admet-2988	588	3	]	]	PUNCT
admet-2988	588	4	r.	r.	PROPN
admet-2988	588	5	khatoon	khatoon	PROPN
admet-2988	588	6	,	,	PUNCT
admet-2988	588	7	a.	a.	PROPN
admet-2988	588	8	alam	alam	PROPN
admet-2988	588	9	,	,	PUNCT
admet-2988	588	10	k.	k.	PROPN
admet-2988	588	11	sharma	sharma	PROPN
admet-2988	588	12	.	.	PUNCT
admet-2988	589	1	current	current	ADJ
admet-2988	589	2	approaches	approach	NOUN
admet-2988	589	3	and	and	CCONJ
admet-2988	589	4	prospective	prospective	ADJ
admet-2988	589	5	drug	drug	NOUN
admet-2988	589	6	targeting	target	VERB
admet-2988	589	7	to	to	AUX
admet-2988	589	8	brain	brain	NOUN
admet-2988	589	9	.	.	PUNCT
admet-2988	590	1	journal	journal	PROPN
admet-2988	590	2	of	of	ADP
admet-2988	590	3	drug	drug	NOUN
admet-2988	590	4	delivery	delivery	NOUN
admet-2988	590	5	science	science	NOUN
admet-2988	590	6	and	and	CCONJ
admet-2988	590	7	technology	technology	NOUN
admet-2988	590	8	61	61	NUM
admet-2988	590	9	(	(	PUNCT
admet-2988	590	10	2020	2020	NUM
admet-2988	590	11	)	)	PUNCT
admet-2988	590	12	102098	102098	NUM
admet-2988	590	13	.	.	PUNCT
admet-2988	591	1	https://doi.org/10.1016/j.jddst.2020.102098	https://doi.org/10.1016/j.jddst.2020.102098	PROPN
admet-2988	592	1	[	[	X
admet-2988	592	2	70	70	NUM
admet-2988	592	3	]	]	PUNCT
admet-2988	592	4	m.	m.	PROPN
admet-2988	592	5	nowak	nowak	PROPN
admet-2988	592	6	,	,	PUNCT
admet-2988	592	7	m.e	m.e	PROPN
admet-2988	592	8	.	.	PROPN
admet-2988	592	9	helgeson	helgeson	PROPN
admet-2988	592	10	,	,	PUNCT
admet-2988	592	11	s.	s.	PROPN
admet-2988	592	12	mitragotri	mitragotri	PROPN
admet-2988	592	13	.	.	PUNCT
admet-2988	593	1	delivery	delivery	NOUN
admet-2988	593	2	of	of	ADP
admet-2988	593	3	nanoparticles	nanoparticle	NOUN
admet-2988	593	4	and	and	CCONJ
admet-2988	593	5	macromolecules	macromolecule	NOUN
admet-2988	593	6	across	across	ADP
admet-2988	593	7	the	the	DET
admet-2988	593	8	blood	blood	NOUN
admet-2988	593	9	-	-	PUNCT
admet-2988	593	10	brain	brain	NOUN
admet-2988	593	11	barrier	barrier	NOUN
admet-2988	593	12	.	.	PUNCT
admet-2988	594	1	advanced	advanced	ADJ
admet-2988	594	2	therapeutics	therapeutic	NOUN
admet-2988	594	3	3	3	NUM
admet-2988	594	4	(	(	PUNCT
admet-2988	594	5	2020	2020	NUM
admet-2988	594	6	)	)	PUNCT
admet-2988	594	7	1900073	1900073	NUM
admet-2988	594	8	.	.	PUNCT
admet-2988	594	9	https://doi.org/10.1002/adtp.201900073	https://doi.org/10.1002/adtp.201900073	NOUN
admet-2988	595	1	[	[	X
admet-2988	595	2	71	71	NUM
admet-2988	595	3	]	]	PUNCT
admet-2988	595	4	s.	s.	PROPN
admet-2988	595	5	masoudi	masoudi	ADJ
admet-2988	595	6	asil	asil	PROPN
admet-2988	595	7	,	,	PUNCT
admet-2988	595	8	j.	j.	PROPN
admet-2988	595	9	ahlawat	ahlawat	PROPN
admet-2988	595	10	,	,	PUNCT
admet-2988	595	11	g.	g.	PROPN
admet-2988	595	12	guillama	guillama	PROPN
admet-2988	595	13	barroso	barroso	PROPN
admet-2988	595	14	,	,	PUNCT
admet-2988	595	15	m.	m.	NOUN
admet-2988	595	16	narayan	narayan	PROPN
admet-2988	595	17	.	.	PUNCT
admet-2988	596	1	nanomaterial	nanomaterial	PROPN
admet-2988	596	2	based	base	VERB
admet-2988	596	3	drug	drug	NOUN
admet-2988	596	4	delivery	delivery	NOUN
admet-2988	596	5	systems	system	NOUN
admet-2988	596	6	for	for	ADP
admet-2988	596	7	the	the	DET
admet-2988	596	8	treatment	treatment	NOUN
admet-2988	596	9	of	of	ADP
admet-2988	596	10	neurodegenerative	neurodegenerative	ADJ
admet-2988	596	11	diseases	disease	NOUN
admet-2988	596	12	.	.	PUNCT
admet-2988	597	1	biomaterials	biomaterial	NOUN
admet-2988	597	2	science	science	NOUN
admet-2988	597	3	8	8	NUM
admet-2988	597	4	(	(	PUNCT
admet-2988	597	5	2020	2020	NUM
admet-2988	597	6	)	)	PUNCT
admet-2988	597	7	4088	4088	NUM
admet-2988	597	8	-	-	SYM
admet-2988	597	9	4107	4107	NUM
admet-2988	597	10	.	.	PUNCT
admet-2988	598	1	https://doi.org/10.1039/d0bm00809e	https://doi.org/10.1039/d0bm00809e	PRON
admet-2988	598	2	[	[	PUNCT
admet-2988	598	3	72	72	NUM
admet-2988	598	4	]	]	PUNCT
admet-2988	598	5	m.	m.	NOUN
admet-2988	598	6	pinkiewicz	pinkiewicz	NOUN
admet-2988	598	7	,	,	PUNCT
admet-2988	598	8	m.	m.	NOUN
admet-2988	598	9	pinkiewicz	pinkiewicz	PROPN
admet-2988	598	10	,	,	PUNCT
admet-2988	598	11	j.	j.	PROPN
admet-2988	598	12	walecki	walecki	PROPN
admet-2988	598	13	,	,	PUNCT
admet-2988	598	14	a.	a.	NOUN
admet-2988	598	15	zaczyński	zaczyński	NOUN
admet-2988	598	16	,	,	PUNCT
admet-2988	598	17	m.	m.	NOUN
admet-2988	598	18	zawadzki	zawadzki	NOUN
admet-2988	598	19	.	.	PUNCT
admet-2988	599	1	breaking	break	VERB
admet-2988	599	2	barriers	barrier	NOUN
admet-2988	599	3	in	in	ADP
admet-2988	599	4	neurooncology	neurooncology	NOUN
admet-2988	599	5	:	:	PUNCT
admet-2988	599	6	a	a	DET
admet-2988	599	7	scoping	scope	VERB
admet-2988	599	8	literature	literature	NOUN
admet-2988	599	9	review	review	NOUN
admet-2988	599	10	on	on	ADP
admet-2988	599	11	invasive	invasive	ADJ
admet-2988	599	12	and	and	CCONJ
admet-2988	599	13	non	non	ADJ
admet-2988	599	14	-	-	ADJ
admet-2988	599	15	invasive	invasive	ADJ
admet-2988	599	16	techniques	technique	NOUN
admet-2988	599	17	for	for	ADP
admet-2988	599	18	blood	blood	NOUN
admet-2988	599	19	-	-	PUNCT
admet-2988	599	20	brain	brain	NOUN
admet-2988	599	21	barrier	barrier	NOUN
admet-2988	599	22	disruption	disruption	NOUN
admet-2988	599	23	.	.	PUNCT
admet-2988	600	1	cancers	cancer	NOUN
admet-2988	600	2	16	16	NUM
admet-2988	600	3	(	(	PUNCT
admet-2988	600	4	2024	2024	NUM
admet-2988	600	5	)	)	PUNCT
admet-2988	600	6	236	236	NUM
admet-2988	600	7	.	.	PUNCT
admet-2988	601	1	https://doi.org/10.3390/cancers16010236	https://doi.org/10.3390/cancers16010236	ADJ
admet-2988	601	2	[	[	X
admet-2988	601	3	73	73	NUM
admet-2988	601	4	]	]	PUNCT
admet-2988	601	5	m.	m.	NOUN
admet-2988	601	6	gernert	gernert	NOUN
admet-2988	601	7	,	,	PUNCT
admet-2988	601	8	m.	m.	NOUN
admet-2988	601	9	feja	feja	PROPN
admet-2988	601	10	.	.	PUNCT
admet-2988	602	1	bypassing	bypass	VERB
admet-2988	602	2	the	the	DET
admet-2988	602	3	blood	blood	NOUN
admet-2988	602	4	-	-	PUNCT
admet-2988	602	5	brain	brain	NOUN
admet-2988	602	6	barrier	barrier	NOUN
admet-2988	602	7	:	:	PUNCT
admet-2988	602	8	direct	direct	ADJ
admet-2988	602	9	intracranial	intracranial	ADJ
admet-2988	602	10	drug	drug	NOUN
admet-2988	602	11	delivery	delivery	NOUN
admet-2988	602	12	in	in	ADP
admet-2988	602	13	epilepsies	epilepsy	NOUN
admet-2988	602	14	.	.	PUNCT
admet-2988	603	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	603	2	12	12	NUM
admet-2988	603	3	(	(	PUNCT
admet-2988	603	4	2020	2020	NUM
admet-2988	603	5	)	)	PUNCT
admet-2988	603	6	1134	1134	NUM
admet-2988	603	7	.	.	PUNCT
admet-2988	604	1	https://doi.org/10.3390/pharmaceutics12121134	https://doi.org/10.3390/pharmaceutics12121134	PROPN
admet-2988	605	1	[	[	X
admet-2988	605	2	74	74	NUM
admet-2988	605	3	]	]	PUNCT
admet-2988	605	4	s.	s.	PROPN
admet-2988	605	5	ul	ul	PROPN
admet-2988	605	6	islam	islam	PROPN
admet-2988	605	7	,	,	PUNCT
admet-2988	605	8	a.	a.	PROPN
admet-2988	605	9	shehzad	shehzad	PROPN
admet-2988	605	10	,	,	PUNCT
admet-2988	605	11	m.	m.	NOUN
admet-2988	605	12	bilal	bilal	PROPN
admet-2988	605	13	ahmed	ahmed	PROPN
admet-2988	605	14	,	,	PUNCT
admet-2988	605	15	y.s	y.s	PROPN
admet-2988	605	16	.	.	PROPN
admet-2988	605	17	lee	lee	PROPN
admet-2988	605	18	.	.	PROPN
admet-2988	606	1	intranasal	intranasal	ADJ
admet-2988	606	2	delivery	delivery	NOUN
admet-2988	606	3	of	of	ADP
admet-2988	606	4	nanoformulations	nanoformulation	NOUN
admet-2988	606	5	:	:	PUNCT
admet-2988	606	6	a	a	DET
admet-2988	606	7	potential	potential	ADJ
admet-2988	606	8	way	way	NOUN
admet-2988	606	9	of	of	ADP
admet-2988	606	10	treatment	treatment	NOUN
admet-2988	606	11	for	for	ADP
admet-2988	606	12	neurological	neurological	ADJ
admet-2988	606	13	disorders	disorder	NOUN
admet-2988	606	14	.	.	PUNCT
admet-2988	607	1	molecules	molecule	NOUN
admet-2988	607	2	25	25	NUM
admet-2988	607	3	(	(	PUNCT
admet-2988	607	4	2020	2020	NUM
admet-2988	607	5	)	)	PUNCT
admet-2988	607	6	1929	1929	NUM
admet-2988	607	7	.	.	PUNCT
admet-2988	608	1	https://doi.org/10.3390/molecules25081929	https://doi.org/10.3390/molecules25081929	NOUN
admet-2988	608	2	[	[	X
admet-2988	608	3	75	75	NUM
admet-2988	608	4	]	]	X
admet-2988	608	5	l.c	l.c	PROPN
admet-2988	608	6	.	.	PROPN
admet-2988	608	7	fonseca	fonseca	PROPN
admet-2988	608	8	,	,	PUNCT
admet-2988	608	9	j.a	j.a	PROPN
admet-2988	608	10	.	.	PROPN
admet-2988	608	11	lopes	lopes	PROPN
admet-2988	608	12	,	,	PUNCT
admet-2988	608	13	j.	j.	PROPN
admet-2988	608	14	vieira	vieira	PROPN
admet-2988	608	15	,	,	PUNCT
admet-2988	608	16	c.	c.	PROPN
admet-2988	608	17	viegas	viegas	PROPN
admet-2988	608	18	,	,	PUNCT
admet-2988	608	19	c.s	c.s	PROPN
admet-2988	608	20	.	.	PROPN
admet-2988	608	21	oliveira	oliveira	PROPN
admet-2988	608	22	,	,	PUNCT
admet-2988	608	23	r.p	r.p	PROPN
admet-2988	608	24	.	.	PROPN
admet-2988	608	25	hartmann	hartmann	PROPN
admet-2988	608	26	,	,	PUNCT
admet-2988	608	27	p.	p.	PROPN
admet-2988	608	28	fonte	fonte	PROPN
admet-2988	608	29	.	.	PUNCT
admet-2988	609	1	intranasal	intranasal	ADJ
admet-2988	609	2	drug	drug	NOUN
admet-2988	609	3	delivery	delivery	NOUN
admet-2988	609	4	for	for	ADP
admet-2988	609	5	treatment	treatment	NOUN
admet-2988	609	6	of	of	ADP
admet-2988	609	7	alzheimer	alzheimer	PROPN
admet-2988	609	8	’s	’s	PART
admet-2988	609	9	disease	disease	NOUN
admet-2988	609	10	.	.	PUNCT
admet-2988	610	1	drug	drug	NOUN
admet-2988	610	2	delivery	delivery	NOUN
admet-2988	610	3	and	and	CCONJ
admet-2988	610	4	translational	translational	ADJ
admet-2988	610	5	research	research	NOUN
admet-2988	610	6	11	11	NUM
admet-2988	610	7	(	(	PUNCT
admet-2988	610	8	2021	2021	NUM
admet-2988	610	9	)	)	PUNCT
admet-2988	610	10	411	411	NUM
admet-2988	610	11	-	-	SYM
admet-2988	610	12	425	425	NUM
admet-2988	610	13	.	.	PUNCT
admet-2988	610	14	https://doi.org/10.1007/s13346-021-00940-7	https://doi.org/10.1007/s13346-021-00940-7	NUM
admet-2988	611	1	[	[	X
admet-2988	611	2	76	76	NUM
admet-2988	611	3	]	]	X
admet-2988	611	4	j.	j.	PROPN
admet-2988	611	5	wen	wen	PROPN
admet-2988	611	6	,	,	PUNCT
admet-2988	611	7	y.	y.	PROPN
admet-2988	611	8	huang	huang	PROPN
admet-2988	611	9	,	,	PUNCT
admet-2988	611	10	t.p	t.p	PROPN
admet-2988	611	11	.	.	PROPN
admet-2988	611	12	crowe	crowe	PROPN
admet-2988	611	13	,	,	PUNCT
admet-2988	611	14	w.h	w.h	PROPN
admet-2988	611	15	.	.	PROPN
admet-2988	611	16	hsu	hsu	PROPN
admet-2988	611	17	.	.	PUNCT
admet-2988	611	18	evaluation	evaluation	NOUN
admet-2988	611	19	of	of	ADP
admet-2988	611	20	recent	recent	ADJ
admet-2988	611	21	intranasal	intranasal	ADJ
admet-2988	611	22	drug	drug	NOUN
admet-2988	611	23	delivery	delivery	NOUN
admet-2988	611	24	systems	system	NOUN
admet-2988	611	25	to	to	ADP
admet-2988	611	26	the	the	DET
admet-2988	611	27	central	central	ADJ
admet-2988	611	28	nervous	nervous	ADJ
admet-2988	611	29	system	system	NOUN
admet-2988	611	30	.	.	PUNCT
admet-2988	612	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	612	2	14	14	NUM
admet-2988	612	3	(	(	PUNCT
admet-2988	612	4	2022	2022	NUM
admet-2988	612	5	)	)	PUNCT
admet-2988	612	6	629	629	NUM
admet-2988	612	7	.	.	PUNCT
admet-2988	613	1	https://doi.org/10.3390/pharmaceutics14030629	https://doi.org/10.3390/pharmaceutics14030629	PROPN
admet-2988	613	2	[	[	X
admet-2988	613	3	77	77	NUM
admet-2988	613	4	]	]	X
admet-2988	613	5	j.	j.	PROPN
admet-2988	613	6	koo	koo	PROPN
admet-2988	613	7	,	,	PUNCT
admet-2988	613	8	y.	y.	PROPN
admet-2988	613	9	shin	shin	PROPN
admet-2988	613	10	,	,	PUNCT
admet-2988	613	11	h.	h.	PROPN
admet-2988	613	12	jeon	jeon	PROPN
admet-2988	613	13	,	,	PUNCT
admet-2988	613	14	j.	j.	PROPN
admet-2988	613	15	cheong	cheong	PROPN
admet-2988	613	16	,	,	PUNCT
admet-2988	613	17	s.	s.	PROPN
admet-2988	613	18	cho	cho	PROPN
admet-2988	613	19	,	,	PUNCT
admet-2988	613	20	c.	c.	PROPN
admet-2988	613	21	park	park	PROPN
admet-2988	613	22	,	,	PUNCT
admet-2988	613	23	e.c	e.c	PROPN
admet-2988	613	24	.	.	PROPN
admet-2988	613	25	song	song	PROPN
admet-2988	613	26	,	,	PUNCT
admet-2988	613	27	j.d	j.d	PROPN
admet-2988	613	28	.	.	PROPN
admet-2988	613	29	ramsey	ramsey	PROPN
admet-2988	613	30	,	,	PUNCT
admet-2988	613	31	c.	c.	PROPN
admet-2988	613	32	lim	lim	PROPN
admet-2988	613	33	,	,	PUNCT
admet-2988	613	34	k.t	k.t	PROPN
admet-2988	613	35	.	.	PROPN
admet-2988	614	1	oh	oh	INTJ
admet-2988	614	2	.	.	PUNCT
admet-2988	615	1	enhancing	enhance	VERB
admet-2988	615	2	glioblastoma	glioblastoma	NOUN
admet-2988	615	3	therapy	therapy	NOUN
admet-2988	615	4	via	via	ADP
admet-2988	615	5	intranasal	intranasal	ADJ
admet-2988	615	6	administration	administration	NOUN
admet-2988	615	7	of	of	ADP
admet-2988	615	8	highly	highly	ADV
admet-2988	615	9	potent	potent	ADJ
admet-2988	615	10	cell	cell	NOUN
admet-2988	615	11	-	-	PUNCT
admet-2988	615	12	penetrating	penetrate	VERB
admet-2988	615	13	peptide	peptide	NOUN
admet-2988	615	14	decorated	decorate	VERB
admet-2988	615	15	nanoparticles	nanoparticle	NOUN
admet-2988	615	16	.	.	PUNCT
admet-2988	616	1	journal	journal	NOUN
admet-2988	616	2	of	of	ADP
admet-2988	616	3	controlled	control	VERB
admet-2988	616	4	release	release	NOUN
admet-2988	616	5	378	378	NUM
admet-2988	616	6	(	(	PUNCT
admet-2988	616	7	2025	2025	NUM
admet-2988	616	8	)	)	PUNCT
admet-2988	616	9	997	997	NUM
admet-2988	616	10	-	-	SYM
admet-2988	616	11	1012	1012	NUM
admet-2988	616	12	.	.	PUNCT
admet-2988	617	1	https://doi.org/10.1016/j.jconrel.2024.12.058	https://doi.org/10.1016/j.jconrel.2024.12.058	ADJ
admet-2988	617	2	[	[	PUNCT
admet-2988	617	3	78	78	NUM
admet-2988	617	4	]	]	PUNCT
admet-2988	617	5	s.	s.	PROPN
admet-2988	617	6	sharma	sharma	PROPN
admet-2988	617	7	,	,	PUNCT
admet-2988	617	8	p.	p.	PROPN
admet-2988	617	9	gauba	gauba	PROPN
admet-2988	617	10	,	,	PUNCT
admet-2988	617	11	a.	a.	PROPN
admet-2988	617	12	tyagi	tyagi	PROPN
admet-2988	617	13	,	,	PUNCT
admet-2988	617	14	s.	s.	PROPN
admet-2988	617	15	dang	dang	PROPN
admet-2988	617	16	.	.	PUNCT
admet-2988	618	1	chitosan	chitosan	NOUN
admet-2988	618	2	-	-	PUNCT
admet-2988	618	3	modified	modify	VERB
admet-2988	618	4	polymeric	polymeric	ADJ
admet-2988	618	5	nanoparticles	nanoparticle	NOUN
admet-2988	618	6	for	for	ADP
admet-2988	618	7	the	the	DET
admet-2988	618	8	nose	nose	NOUN
admet-2988	618	9	-	-	PUNCT
admet-2988	618	10	tobrain	tobrain	NOUN
admet-2988	618	11	drug	drug	NOUN
admet-2988	618	12	delivery	delivery	NOUN
admet-2988	618	13	of	of	ADP
admet-2988	618	14	paroxetine	paroxetine	NOUN
admet-2988	618	15	:	:	PUNCT
admet-2988	618	16	an	an	PRON
admet-2988	618	17	in	in	ADP
admet-2988	618	18	vitro	vitro	X
admet-2988	618	19	and	and	CCONJ
admet-2988	618	20	in	in	ADP
admet-2988	618	21	vivo	vivo	ADJ
admet-2988	618	22	evaluation	evaluation	NOUN
admet-2988	618	23	.	.	PUNCT
admet-2988	619	1	nanoscale	nanoscale	NOUN
admet-2988	619	2	17	17	NUM
admet-2988	619	3	(	(	PUNCT
admet-2988	619	4	2025	2025	NUM
admet-2988	619	5	)	)	PUNCT
admet-2988	619	6	16871702	16871702	NUM
admet-2988	619	7	.	.	PUNCT
admet-2988	620	1	https://doi.org/10.1039/d4nr04250f	https://doi.org/10.1039/d4nr04250f	PROPN
admet-2988	621	1	[	[	X
admet-2988	621	2	79	79	NUM
admet-2988	621	3	]	]	X
admet-2988	621	4	v.	v.	X
admet-2988	621	5	deshmukh	deshmukh	PROPN
admet-2988	621	6	,	,	PUNCT
admet-2988	621	7	m.	m.	NOUN
admet-2988	621	8	narwade	narwade	PROPN
admet-2988	621	9	,	,	PUNCT
admet-2988	621	10	k.r	k.r	PROPN
admet-2988	621	11	.	.	PROPN
admet-2988	621	12	gajbhiye	gajbhiye	PROPN
admet-2988	621	13	.	.	PUNCT
admet-2988	622	1	intranasal	intranasal	ADJ
admet-2988	622	2	delivery	delivery	NOUN
admet-2988	622	3	of	of	ADP
admet-2988	622	4	paclitaxel	paclitaxel	NOUN
admet-2988	622	5	-	-	PUNCT
admet-2988	622	6	loaded	load	VERB
admet-2988	622	7	ligand	ligand	NOUN
admet-2988	622	8	conjugated	conjugate	VERB
admet-2988	622	9	polymeric	polymeric	ADJ
admet-2988	622	10	nanoparticles	nanoparticle	NOUN
admet-2988	622	11	for	for	ADP
admet-2988	622	12	targeted	target	VERB
admet-2988	622	13	brain	brain	NOUN
admet-2988	622	14	delivery	delivery	NOUN
admet-2988	622	15	.	.	PUNCT
admet-2988	623	1	aaps	aap	NOUN
admet-2988	623	2	pharmscitech	pharmscitech	VERB
admet-2988	623	3	26	26	NUM
admet-2988	623	4	(	(	PUNCT
admet-2988	623	5	2025	2025	NUM
admet-2988	623	6	)	)	PUNCT
admet-2988	623	7	49	49	NUM
admet-2988	623	8	.	.	PUNCT
admet-2988	624	1	https://doi.org/10.1208/s12249-025-03046-2	https://doi.org/10.1208/s12249-025-03046-2	NOUN
admet-2988	625	1	[	[	X
admet-2988	625	2	80	80	NUM
admet-2988	625	3	]	]	X
admet-2988	625	4	h.	h.	PROPN
admet-2988	625	5	fu	fu	PROPN
admet-2988	625	6	,	,	PUNCT
admet-2988	625	7	d.m	d.m	PROPN
admet-2988	625	8	.	.	PROPN
admet-2988	625	9	mccarty	mccarty	PROPN
admet-2988	625	10	.	.	PUNCT
admet-2988	625	11	crossing	cross	VERB
admet-2988	625	12	the	the	DET
admet-2988	625	13	blood	blood	NOUN
admet-2988	625	14	-	-	PUNCT
admet-2988	625	15	brain	brain	NOUN
admet-2988	625	16	-	-	PUNCT
admet-2988	625	17	barrier	barrier	NOUN
admet-2988	625	18	with	with	ADP
admet-2988	625	19	viral	viral	ADJ
admet-2988	625	20	vectors	vector	NOUN
admet-2988	625	21	.	.	PUNCT
admet-2988	626	1	current	current	ADJ
admet-2988	626	2	opinion	opinion	NOUN
admet-2988	626	3	in	in	ADP
admet-2988	626	4	virology	virology	NOUN
admet-2988	626	5	21	21	NUM
admet-2988	626	6	(	(	PUNCT
admet-2988	626	7	2016	2016	NUM
admet-2988	626	8	)	)	PUNCT
admet-2988	626	9	87	87	NUM
admet-2988	626	10	-	-	SYM
admet-2988	626	11	92	92	NUM
admet-2988	626	12	.	.	PUNCT
admet-2988	627	1	https://doi.org/10.1016/j.coviro.2016.08.006	https://doi.org/10.1016/j.coviro.2016.08.006	PROPN
admet-2988	627	2	[	[	X
admet-2988	627	3	81	81	NUM
admet-2988	627	4	]	]	X
admet-2988	627	5	g.c	g.c	PROPN
admet-2988	627	6	.	.	PROPN
admet-2988	627	7	terstappen	terstappen	PROPN
admet-2988	627	8	,	,	PUNCT
admet-2988	627	9	a.h	a.h	PROPN
admet-2988	627	10	.	.	PROPN
admet-2988	627	11	meyer	meyer	PROPN
admet-2988	627	12	,	,	PUNCT
admet-2988	627	13	r.d	r.d	PROPN
admet-2988	627	14	.	.	PROPN
admet-2988	627	15	bell	bell	PROPN
admet-2988	627	16	,	,	PUNCT
admet-2988	627	17	w.	w.	PROPN
admet-2988	627	18	zhang	zhang	PROPN
admet-2988	627	19	.	.	PUNCT
admet-2988	628	1	strategies	strategy	NOUN
admet-2988	628	2	for	for	ADP
admet-2988	628	3	delivering	deliver	VERB
admet-2988	628	4	therapeutics	therapeutic	NOUN
admet-2988	628	5	across	across	ADP
admet-2988	628	6	the	the	DET
admet-2988	628	7	blood	blood	NOUN
admet-2988	628	8	-	-	PUNCT
admet-2988	628	9	brain	brain	NOUN
admet-2988	628	10	barrier	barrier	NOUN
admet-2988	628	11	.	.	PUNCT
admet-2988	629	1	nature	nature	NOUN
admet-2988	629	2	reviews	review	VERB
admet-2988	629	3	drug	drug	NOUN
admet-2988	629	4	discovery	discovery	NOUN
admet-2988	629	5	20	20	NUM
admet-2988	629	6	(	(	PUNCT
admet-2988	629	7	2021	2021	NUM
admet-2988	629	8	)	)	PUNCT
admet-2988	629	9	362	362	NUM
admet-2988	629	10	-	-	SYM
admet-2988	629	11	383	383	NUM
admet-2988	629	12	.	.	PUNCT
admet-2988	630	1	https://doi.org/10.1038/s41573-021-00139-y	https://doi.org/10.1038/s41573-021-00139-y	X
admet-2988	631	1	[	[	X
admet-2988	631	2	82	82	NUM
admet-2988	631	3	]	]	X
admet-2988	631	4	m.	m.	NOUN
admet-2988	631	5	charabati	charabati	PROPN
admet-2988	631	6	,	,	PUNCT
admet-2988	631	7	j.m	j.m	PROPN
admet-2988	631	8	.	.	PROPN
admet-2988	631	9	rabanel	rabanel	PROPN
admet-2988	631	10	,	,	PUNCT
admet-2988	631	11	c.	c.	NOUN
admet-2988	631	12	ramassamy	ramassamy	NOUN
admet-2988	631	13	,	,	PUNCT
admet-2988	631	14	a.	a.	NOUN
admet-2988	631	15	prat	prat	NOUN
admet-2988	631	16	.	.	PUNCT
admet-2988	632	1	overcoming	overcome	VERB
admet-2988	632	2	the	the	DET
admet-2988	632	3	brain	brain	NOUN
admet-2988	632	4	barriers	barrier	NOUN
admet-2988	632	5	:	:	PUNCT
admet-2988	632	6	from	from	ADP
admet-2988	632	7	immune	immune	ADJ
admet-2988	632	8	cells	cell	NOUN
admet-2988	632	9	to	to	ADP
admet-2988	632	10	nanoparticles	nanoparticle	NOUN
admet-2988	632	11	.	.	PUNCT
admet-2988	633	1	trends	trend	NOUN
admet-2988	633	2	in	in	ADP
admet-2988	633	3	pharmacological	pharmacological	ADJ
admet-2988	633	4	sciences	science	NOUN
admet-2988	633	5	41	41	NUM
admet-2988	633	6	(	(	PUNCT
admet-2988	633	7	2020	2020	NUM
admet-2988	633	8	)	)	PUNCT
admet-2988	633	9	42	42	NUM
admet-2988	633	10	-	-	SYM
admet-2988	633	11	54	54	NUM
admet-2988	633	12	.	.	PUNCT
admet-2988	634	1	https://doi.org/10.1016/j.tips.2019.11.001	https://doi.org/10.1016/j.tips.2019.11.001	NOUN
admet-2988	635	1	[	[	X
admet-2988	635	2	83	83	NUM
admet-2988	635	3	]	]	PUNCT
admet-2988	635	4	j.	j.	PROPN
admet-2988	635	5	saint	saint	PROPN
admet-2988	635	6	-	-	PUNCT
admet-2988	635	7	pol	pol	PROPN
admet-2988	635	8	,	,	PUNCT
admet-2988	635	9	f.	f.	PROPN
admet-2988	635	10	gosselet	gosselet	PROPN
admet-2988	635	11	,	,	PUNCT
admet-2988	635	12	s.	s.	PROPN
admet-2988	635	13	duban	duban	PROPN
admet-2988	635	14	-	-	PUNCT
admet-2988	635	15	deweer	deweer	NOUN
admet-2988	635	16	,	,	PUNCT
admet-2988	635	17	g.	g.	PROPN
admet-2988	635	18	pottiez	pottiez	PROPN
admet-2988	635	19	,	,	PUNCT
admet-2988	635	20	y.	y.	PROPN
admet-2988	635	21	karamanos	karamanos	PROPN
admet-2988	635	22	.	.	PUNCT
admet-2988	636	1	targeting	target	VERB
admet-2988	636	2	and	and	CCONJ
admet-2988	636	3	crossing	cross	VERB
admet-2988	636	4	the	the	DET
admet-2988	636	5	blood	blood	NOUN
admet-2988	636	6	-	-	PUNCT
admet-2988	636	7	brain	brain	NOUN
admet-2988	636	8	barrier	barrier	NOUN
admet-2988	636	9	with	with	ADP
admet-2988	636	10	extracellular	extracellular	ADJ
admet-2988	636	11	vesicles	vesicle	NOUN
admet-2988	636	12	.	.	PUNCT
admet-2988	637	1	cells	cell	NOUN
admet-2988	637	2	9	9	NUM
admet-2988	637	3	(	(	PUNCT
admet-2988	637	4	2020	2020	NUM
admet-2988	637	5	)	)	PUNCT
admet-2988	637	6	851	851	NUM
admet-2988	637	7	.	.	PUNCT
admet-2988	638	1	https://doi.org/10.3390/cells9040851	https://doi.org/10.3390/cells9040851	NOUN
admet-2988	639	1	[	[	X
admet-2988	639	2	84	84	NUM
admet-2988	639	3	]	]	SYM
admet-2988	639	4	d.b	d.b	PROPN
admet-2988	639	5	.	.	PROPN
admet-2988	639	6	stanimirović	stanimirović	PROPN
admet-2988	639	7	,	,	PUNCT
admet-2988	639	8	j.k	j.k	PROPN
admet-2988	639	9	.	.	PROPN
admet-2988	639	10	sandhu	sandhu	PROPN
admet-2988	639	11	,	,	PUNCT
admet-2988	639	12	w.j	w.j	PROPN
admet-2988	639	13	.	.	PROPN
admet-2988	639	14	costain	costain	PROPN
admet-2988	639	15	.	.	PUNCT
admet-2988	640	1	emerging	emerge	VERB
admet-2988	640	2	technologies	technology	NOUN
admet-2988	640	3	for	for	ADP
admet-2988	640	4	delivery	delivery	NOUN
admet-2988	640	5	of	of	ADP
admet-2988	640	6	biotherapeutics	biotherapeutic	NOUN
admet-2988	640	7	and	and	CCONJ
admet-2988	640	8	gene	gene	NOUN
admet-2988	640	9	therapy	therapy	NOUN
admet-2988	640	10	across	across	ADP
admet-2988	640	11	the	the	DET
admet-2988	640	12	blood	blood	NOUN
admet-2988	640	13	-	-	PUNCT
admet-2988	640	14	brain	brain	NOUN
admet-2988	640	15	barrier	barrier	NOUN
admet-2988	640	16	.	.	PUNCT
admet-2988	641	1	biodrugs	biodrug	NOUN
admet-2988	641	2	32	32	NUM
admet-2988	641	3	(	(	PUNCT
admet-2988	641	4	2018	2018	NUM
admet-2988	641	5	)	)	PUNCT
admet-2988	641	6	547	547	NUM
admet-2988	641	7	-	-	SYM
admet-2988	641	8	559	559	NUM
admet-2988	641	9	.	.	PUNCT
admet-2988	642	1	https://doi.org/10.1007/s40259-018-0309-y	https://doi.org/10.1007/s40259-018-0309-y	PROPN
admet-2988	642	2	[	[	X
admet-2988	642	3	85	85	NUM
admet-2988	642	4	]	]	PUNCT
admet-2988	642	5	j.	j.	PROPN
admet-2988	642	6	matsumoto	matsumoto	PROPN
admet-2988	642	7	,	,	PUNCT
admet-2988	642	8	t.	t.	PROPN
admet-2988	642	9	stewart	stewart	PROPN
admet-2988	642	10	,	,	PUNCT
admet-2988	642	11	w.a	w.a	PROPN
admet-2988	642	12	.	.	PROPN
admet-2988	642	13	banks	banks	PROPN
admet-2988	642	14	,	,	PUNCT
admet-2988	642	15	j.	j.	PROPN
admet-2988	642	16	zhang	zhang	PROPN
admet-2988	642	17	.	.	PUNCT
admet-2988	643	1	the	the	DET
admet-2988	643	2	transport	transport	NOUN
admet-2988	643	3	mechanism	mechanism	NOUN
admet-2988	643	4	of	of	ADP
admet-2988	643	5	extracellular	extracellular	ADJ
admet-2988	643	6	vesicles	vesicle	NOUN
admet-2988	643	7	at	at	ADP
admet-2988	643	8	the	the	DET
admet-2988	643	9	blood	blood	NOUN
admet-2988	643	10	-	-	PUNCT
admet-2988	643	11	brain	brain	NOUN
admet-2988	643	12	barrier	barrier	NOUN
admet-2988	643	13	.	.	PUNCT
admet-2988	644	1	current	current	ADJ
admet-2988	644	2	pharmaceutical	pharmaceutical	NOUN
admet-2988	644	3	design	design	NOUN
admet-2988	644	4	23	23	NUM
admet-2988	644	5	(	(	PUNCT
admet-2988	644	6	2018	2018	NUM
admet-2988	644	7	)	)	PUNCT
admet-2988	644	8	6206	6206	NUM
admet-2988	644	9	-	-	SYM
admet-2988	644	10	6214	6214	NUM
admet-2988	644	11	.	.	PUNCT
admet-2988	645	1	https://doi.org/10.2174/1381612823666170913164738	https://doi.org/10.2174/1381612823666170913164738	NOUN
admet-2988	645	2	https://doi.org/10.1016/j.jddst.2020.102098	https://doi.org/10.1016/j.jddst.2020.102098	VERB
admet-2988	645	3	https://doi.org/10.1002/adtp.201900073	https://doi.org/10.1002/adtp.201900073	NOUN
admet-2988	645	4	https://doi.org/10.1039/d0bm00809e	https://doi.org/10.1039/d0bm00809e	NOUN
admet-2988	645	5	https://doi.org/10.3390/cancers16010236	https://doi.org/10.3390/cancers16010236	ADJ
admet-2988	645	6	https://doi.org/10.3390/pharmaceutics12121134	https://doi.org/10.3390/pharmaceutics12121134	NOUN
admet-2988	645	7	https://doi.org/10.3390/molecules25081929	https://doi.org/10.3390/molecules25081929	NOUN
admet-2988	645	8	https://doi.org/10.1007/s13346-021-00940-7	https://doi.org/10.1007/s13346-021-00940-7	ADJ
admet-2988	645	9	https://doi.org/10.3390/pharmaceutics14030629	https://doi.org/10.3390/pharmaceutics14030629	PROPN
admet-2988	645	10	https://doi.org/10.1016/j.jconrel.2024.12.058	https://doi.org/10.1016/j.jconrel.2024.12.058	PROPN
admet-2988	645	11	https://doi.org/10.1039/d4nr04250f	https://doi.org/10.1039/d4nr04250f	PROPN
admet-2988	645	12	https://doi.org/10.1208/s12249-025-03046-2	https://doi.org/10.1208/s12249-025-03046-2	PART
admet-2988	645	13	https://doi.org/10.1016/j.coviro.2016.08.006	https://doi.org/10.1016/j.coviro.2016.08.006	NOUN
admet-2988	646	1	https://doi.org/10.1038/s41573-021-00139-y	https://doi.org/10.1038/s41573-021-00139-y	PROPN
admet-2988	646	2	https://doi.org/10.1016/j.tips.2019.11.001	https://doi.org/10.1016/j.tips.2019.11.001	VERB
admet-2988	646	3	https://doi.org/10.3390/cells9040851	https://doi.org/10.3390/cells9040851	NOUN
admet-2988	646	4	https://doi.org/10.1007/s40259-018-0309-y	https://doi.org/10.1007/s40259-018-0309-y	PROPN
admet-2988	646	5	https://doi.org/10.2174/1381612823666170913164738	https://doi.org/10.2174/1381612823666170913164738	NUM
admet-2988	646	6	admet	admet	PROPN
admet-2988	646	7	&	&	CCONJ
admet-2988	646	8	dmpk	dmpk	PROPN
admet-2988	646	9	13(5	13(5	NUM
admet-2988	646	10	)	)	PUNCT
admet-2988	646	11	(	(	PUNCT
admet-2988	646	12	2025	2025	NUM
admet-2988	646	13	)	)	PUNCT
admet-2988	646	14	2988	2988	NUM
admet-2988	646	15	advancing	advance	VERB
admet-2988	646	16	through	through	ADP
admet-2988	646	17	the	the	DET
admet-2988	646	18	blood	blood	NOUN
admet-2988	646	19	-	-	PUNCT
admet-2988	646	20	brain	brain	NOUN
admet-2988	646	21	barrier	barrier	NOUN
admet-2988	646	22	doi	doi	NOUN
admet-2988	646	23	:	:	PUNCT
admet-2988	646	24	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	646	25	21	21	NUM
admet-2988	646	26	[	[	SYM
admet-2988	646	27	86	86	NUM
admet-2988	646	28	]	]	PUNCT
admet-2988	646	29	p.	p.	PROPN
admet-2988	646	30	jiang	jiang	PROPN
admet-2988	646	31	,	,	PUNCT
admet-2988	646	32	y.	y.	PROPN
admet-2988	646	33	xiao	xiao	PROPN
admet-2988	646	34	,	,	PUNCT
admet-2988	646	35	x.	x.	PROPN
admet-2988	646	36	hu	hu	PROPN
admet-2988	646	37	,	,	PUNCT
admet-2988	646	38	c.	c.	PROPN
admet-2988	646	39	wang	wang	PROPN
admet-2988	646	40	,	,	PUNCT
admet-2988	646	41	h.	h.	PROPN
admet-2988	646	42	gao	gao	PROPN
admet-2988	646	43	,	,	PUNCT
admet-2988	646	44	h.	h.	PROPN
admet-2988	646	45	huang	huang	PROPN
admet-2988	646	46	,	,	PUNCT
admet-2988	646	47	j.	j.	PROPN
admet-2988	646	48	lv	lv	PROPN
admet-2988	646	49	,	,	PUNCT
admet-2988	646	50	z.	z.	PROPN
admet-2988	646	51	qi	qi	PROPN
admet-2988	646	52	,	,	PUNCT
admet-2988	646	53	z.	z.	PROPN
admet-2988	646	54	wang	wang	PROPN
admet-2988	646	55	.	.	PUNCT
admet-2988	647	1	rvg29	rvg29	PROPN
admet-2988	647	2	peptide	peptide	NOUN
admet-2988	647	3	-	-	PUNCT
admet-2988	647	4	modified	modify	VERB
admet-2988	647	5	exosomes	exosome	NOUN
admet-2988	647	6	loaded	load	VERB
admet-2988	647	7	with	with	ADP
admet-2988	647	8	mir-133b	mir-133b	NOUN
admet-2988	647	9	mediate	mediate	VERB
admet-2988	647	10	the	the	DET
admet-2988	647	11	rhoa	rhoa	NOUN
admet-2988	647	12	-	-	PUNCT
admet-2988	647	13	rock	rock	NOUN
admet-2988	647	14	pathway	pathway	NOUN
admet-2988	647	15	to	to	PART
admet-2988	647	16	improve	improve	VERB
admet-2988	647	17	motor	motor	NOUN
admet-2988	647	18	and	and	CCONJ
admet-2988	647	19	neurological	neurological	ADJ
admet-2988	647	20	symptoms	symptom	NOUN
admet-2988	647	21	in	in	ADP
admet-2988	647	22	parkinson	parkinson	NOUN
admet-2988	647	23	’s	’s	PART
admet-2988	647	24	disease	disease	NOUN
admet-2988	647	25	.	.	PUNCT
admet-2988	648	1	acs	acs	PROPN
admet-2988	648	2	biomaterials	biomaterial	VERB
admet-2988	648	3	science	science	NOUN
admet-2988	648	4	and	and	CCONJ
admet-2988	648	5	engineering	engineering	NOUN
admet-2988	648	6	10	10	NUM
admet-2988	648	7	(	(	PUNCT
admet-2988	648	8	2024	2024	NUM
admet-2988	648	9	)	)	PUNCT
admet-2988	648	10	3069	3069	NUM
admet-2988	648	11	-	-	SYM
admet-2988	648	12	3085	3085	NUM
admet-2988	648	13	.	.	PUNCT
admet-2988	649	1	https://doi.org/10.1021/acsbiomaterials.3c01622	https://doi.org/10.1021/acsbiomaterials.3c01622	PRON
admet-2988	650	1	[	[	X
admet-2988	650	2	87	87	NUM
admet-2988	650	3	]	]	PUNCT
admet-2988	650	4	k.	k.	PROPN
admet-2988	650	5	haroon	haroon	PROPN
admet-2988	650	6	,	,	PUNCT
admet-2988	650	7	h.	h.	PROPN
admet-2988	650	8	zheng	zheng	PROPN
admet-2988	650	9	,	,	PUNCT
admet-2988	650	10	s.	s.	PROPN
admet-2988	650	11	wu	wu	PROPN
admet-2988	650	12	,	,	PUNCT
admet-2988	650	13	z.	z.	PROPN
admet-2988	650	14	liu	liu	PROPN
admet-2988	650	15	,	,	PUNCT
admet-2988	650	16	y.	y.	PROPN
admet-2988	650	17	tang	tang	PROPN
admet-2988	650	18	,	,	PUNCT
admet-2988	650	19	g.y	g.y	PROPN
admet-2988	650	20	.	.	PROPN
admet-2988	650	21	yang	yang	PROPN
admet-2988	650	22	,	,	PUNCT
admet-2988	650	23	y.	y.	PROPN
admet-2988	650	24	liu	liu	PROPN
admet-2988	650	25	,	,	PUNCT
admet-2988	650	26	z.	z.	PROPN
admet-2988	650	27	zhang	zhang	PROPN
admet-2988	650	28	.	.	PROPN
admet-2988	651	1	engineered	engineer	VERB
admet-2988	651	2	exosomes	exosome	NOUN
admet-2988	651	3	mediated	mediate	VERB
admet-2988	651	4	targeted	target	VERB
admet-2988	651	5	delivery	delivery	NOUN
admet-2988	651	6	of	of	ADP
admet-2988	651	7	neuroprotective	neuroprotective	ADJ
admet-2988	651	8	peptide	peptide	NOUN
admet-2988	651	9	nr2b9c	nr2b9c	PROPN
admet-2988	651	10	for	for	ADP
admet-2988	651	11	the	the	DET
admet-2988	651	12	treatment	treatment	NOUN
admet-2988	651	13	of	of	ADP
admet-2988	651	14	traumatic	traumatic	ADJ
admet-2988	651	15	brain	brain	NOUN
admet-2988	651	16	injury	injury	NOUN
admet-2988	651	17	.	.	PUNCT
admet-2988	652	1	international	international	ADJ
admet-2988	652	2	journal	journal	PROPN
admet-2988	652	3	of	of	ADP
admet-2988	652	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	652	5	649	649	NUM
admet-2988	652	6	(	(	PUNCT
admet-2988	652	7	2024	2024	NUM
admet-2988	652	8	)	)	PUNCT
admet-2988	652	9	123656	123656	NUM
admet-2988	652	10	.	.	PUNCT
admet-2988	653	1	https://doi.org/10.1016/j.ijpharm.2023.123656	https://doi.org/10.1016/j.ijpharm.2023.123656	ADJ
admet-2988	653	2	[	[	X
admet-2988	653	3	88	88	NUM
admet-2988	653	4	]	]	PUNCT
admet-2988	653	5	p.	p.	NOUN
admet-2988	653	6	pourmasoumi	pourmasoumi	NOUN
admet-2988	653	7	,	,	PUNCT
admet-2988	653	8	m.	m.	NOUN
admet-2988	653	9	abdouss	abdouss	NOUN
admet-2988	653	10	,	,	PUNCT
admet-2988	653	11	m.	m.	NOUN
admet-2988	653	12	farhadi	farhadi	PROPN
admet-2988	653	13	,	,	PUNCT
admet-2988	653	14	s.b	s.b	PROPN
admet-2988	653	15	.	.	PROPN
admet-2988	653	16	jameie	jameie	PROPN
admet-2988	653	17	,	,	PUNCT
admet-2988	653	18	h.a	h.a	PROPN
admet-2988	653	19	.	.	PROPN
admet-2988	653	20	khonakdar	khonakdar	PROPN
admet-2988	653	21	.	.	PUNCT
admet-2988	654	1	co	co	NOUN
admet-2988	655	1	-	-	NOUN
admet-2988	655	2	delivery	delivery	NOUN
admet-2988	655	3	of	of	ADP
admet-2988	655	4	temozolomide	temozolomide	NOUN
admet-2988	655	5	and	and	CCONJ
admet-2988	655	6	quercetin	quercetin	NOUN
admet-2988	655	7	with	with	ADP
admet-2988	655	8	folic	folic	ADJ
admet-2988	655	9	acid	acid	NOUN
admet-2988	655	10	-	-	PUNCT
admet-2988	655	11	conjugated	conjugate	VERB
admet-2988	655	12	exosomes	exosome	NOUN
admet-2988	655	13	in	in	ADP
admet-2988	655	14	glioblastoma	glioblastoma	NOUN
admet-2988	655	15	treatment	treatment	NOUN
admet-2988	655	16	.	.	PUNCT
admet-2988	656	1	nanomedicine	nanomedicine	NOUN
admet-2988	656	2	19	19	NUM
admet-2988	656	3	(	(	PUNCT
admet-2988	656	4	2024	2024	NUM
admet-2988	656	5	)	)	PUNCT
admet-2988	656	6	2271	2271	NUM
admet-2988	656	7	-	-	SYM
admet-2988	656	8	2287	2287	NUM
admet-2988	656	9	.	.	PUNCT
admet-2988	657	1	https://doi.org/10.1080/17435889.2024.2395234	https://doi.org/10.1080/17435889.2024.2395234	X
admet-2988	658	1	[	[	X
admet-2988	658	2	89	89	NUM
admet-2988	658	3	]	]	PUNCT
admet-2988	658	4	m.	m.	NOUN
admet-2988	658	5	sánchez	sánchez	PROPN
admet-2988	658	6	-	-	PUNCT
admet-2988	658	7	navarro	navarro	PROPN
admet-2988	658	8	,	,	PUNCT
admet-2988	658	9	e.	e.	PROPN
admet-2988	658	10	giralt	giralt	PROPN
admet-2988	658	11	,	,	PUNCT
admet-2988	658	12	m.	m.	NOUN
admet-2988	658	13	teixidó	teixidó	NOUN
admet-2988	658	14	.	.	PUNCT
admet-2988	659	1	blood	blood	NOUN
admet-2988	659	2	-	-	PUNCT
admet-2988	659	3	brain	brain	NOUN
admet-2988	659	4	barrier	barrier	NOUN
admet-2988	659	5	peptide	peptide	NOUN
admet-2988	659	6	shuttles	shuttle	NOUN
admet-2988	659	7	.	.	PUNCT
admet-2988	660	1	current	current	ADJ
admet-2988	660	2	opinion	opinion	NOUN
admet-2988	660	3	in	in	ADP
admet-2988	660	4	chemical	chemical	NOUN
admet-2988	660	5	biology	biology	NOUN
admet-2988	660	6	38	38	NUM
admet-2988	660	7	(	(	PUNCT
admet-2988	660	8	2017	2017	NUM
admet-2988	660	9	)	)	PUNCT
admet-2988	660	10	134	134	NUM
admet-2988	660	11	-	-	SYM
admet-2988	660	12	140	140	NUM
admet-2988	660	13	.	.	PUNCT
admet-2988	661	1	https://doi.org/10.1016/j.cbpa.2017.04.019	https://doi.org/10.1016/j.cbpa.2017.04.019	NUM
admet-2988	661	2	[	[	X
admet-2988	661	3	90	90	NUM
admet-2988	661	4	]	]	PUNCT
admet-2988	661	5	m.	m.	NOUN
admet-2988	661	6	teixidó	teixidó	PROPN
admet-2988	661	7	,	,	PUNCT
admet-2988	661	8	e.	e.	PROPN
admet-2988	661	9	zurita	zurita	PROPN
admet-2988	661	10	,	,	PUNCT
admet-2988	661	11	m.	m.	NOUN
admet-2988	661	12	malakoutikhah	malakoutikhah	PROPN
admet-2988	661	13	,	,	PUNCT
admet-2988	661	14	t.	t.	PROPN
admet-2988	661	15	tarragó	tarragó	PROPN
admet-2988	661	16	,	,	PUNCT
admet-2988	661	17	e.	e.	PROPN
admet-2988	661	18	giralt	giralt	PROPN
admet-2988	661	19	.	.	PUNCT
admet-2988	662	1	diketopiperazines	diketopiperazine	NOUN
admet-2988	662	2	as	as	ADP
admet-2988	662	3	a	a	DET
admet-2988	662	4	tool	tool	NOUN
admet-2988	662	5	for	for	ADP
admet-2988	662	6	the	the	DET
admet-2988	662	7	study	study	NOUN
admet-2988	662	8	of	of	ADP
admet-2988	662	9	transport	transport	NOUN
admet-2988	662	10	across	across	ADP
admet-2988	662	11	the	the	DET
admet-2988	662	12	blood	blood	NOUN
admet-2988	662	13	-	-	PUNCT
admet-2988	662	14	brain	brain	NOUN
admet-2988	662	15	barrier	barrier	NOUN
admet-2988	662	16	(	(	PUNCT
admet-2988	662	17	bbb	bbb	NOUN
admet-2988	662	18	)	)	PUNCT
admet-2988	662	19	and	and	CCONJ
admet-2988	662	20	their	their	PRON
admet-2988	662	21	potential	potential	ADJ
admet-2988	662	22	use	use	NOUN
admet-2988	662	23	as	as	ADP
admet-2988	662	24	bbb	bbb	NOUN
admet-2988	662	25	-	-	PUNCT
admet-2988	662	26	shuttles	shuttle	NOUN
admet-2988	662	27	.	.	PUNCT
admet-2988	663	1	journal	journal	NOUN
admet-2988	663	2	of	of	ADP
admet-2988	663	3	the	the	DET
admet-2988	663	4	american	american	PROPN
admet-2988	663	5	chemical	chemical	PROPN
admet-2988	663	6	society	society	PROPN
admet-2988	663	7	129	129	NUM
admet-2988	663	8	(	(	PUNCT
admet-2988	663	9	2007	2007	NUM
admet-2988	663	10	)	)	PUNCT
admet-2988	663	11	11802	11802	NUM
admet-2988	663	12	-	-	SYM
admet-2988	663	13	11813	11813	NUM
admet-2988	663	14	.	.	PUNCT
admet-2988	664	1	https://doi.org/10.1021/ja073522o	https://doi.org/10.1021/ja073522o	PROPN
admet-2988	665	1	[	[	X
admet-2988	665	2	91	91	NUM
admet-2988	665	3	]	]	X
admet-2988	665	4	y.	y.	PROPN
admet-2988	665	5	anami	anami	PROPN
admet-2988	665	6	,	,	PUNCT
admet-2988	665	7	w.	w.	PROPN
admet-2988	665	8	xiong	xiong	PROPN
admet-2988	665	9	,	,	PUNCT
admet-2988	665	10	a.	a.	PROPN
admet-2988	665	11	yamaguchi	yamaguchi	PROPN
admet-2988	665	12	,	,	PUNCT
admet-2988	665	13	c.m	c.m	PROPN
admet-2988	665	14	.	.	PROPN
admet-2988	665	15	yamazaki	yamazaki	PROPN
admet-2988	665	16	,	,	PUNCT
admet-2988	665	17	n.	n.	PROPN
admet-2988	665	18	zhang	zhang	PROPN
admet-2988	665	19	,	,	PUNCT
admet-2988	665	20	z.	z.	PROPN
admet-2988	665	21	an	an	PROPN
admet-2988	665	22	,	,	PUNCT
admet-2988	665	23	k.	k.	NOUN
admet-2988	665	24	tsuchikama	tsuchikama	PROPN
admet-2988	665	25	.	.	PUNCT
admet-2988	666	1	homogeneous	homogeneous	ADJ
admet-2988	666	2	antibody	antibody	NOUN
admet-2988	666	3	-	-	PUNCT
admet-2988	666	4	angiopep	angiopep	NOUN
admet-2988	666	5	2	2	NUM
admet-2988	666	6	conjugates	conjugate	NOUN
admet-2988	666	7	for	for	ADP
admet-2988	666	8	effective	effective	ADJ
admet-2988	666	9	brain	brain	NOUN
admet-2988	666	10	targeting	targeting	NOUN
admet-2988	666	11	.	.	PUNCT
admet-2988	667	1	rsc	rsc	PROPN
admet-2988	667	2	advances	advance	VERB
admet-2988	667	3	12	12	NUM
admet-2988	667	4	(	(	PUNCT
admet-2988	667	5	2022	2022	NUM
admet-2988	667	6	)	)	PUNCT
admet-2988	667	7	3359	3359	NUM
admet-2988	667	8	-	-	SYM
admet-2988	667	9	3364	3364	NUM
admet-2988	667	10	.	.	PUNCT
admet-2988	668	1	https://doi.org/10.1039/d1ra08131d	https://doi.org/10.1039/d1ra08131d	PROPN
admet-2988	669	1	[	[	X
admet-2988	669	2	92	92	NUM
admet-2988	669	3	]	]	PUNCT
admet-2988	669	4	a.	a.	PROPN
admet-2988	669	5	regina	regina	PROPN
admet-2988	669	6	,	,	PUNCT
admet-2988	669	7	m.	m.	NOUN
admet-2988	669	8	demeule	demeule	PROPN
admet-2988	669	9	,	,	PUNCT
admet-2988	669	10	s.	s.	PROPN
admet-2988	669	11	tripathy	tripathy	PROPN
admet-2988	669	12	,	,	PUNCT
admet-2988	669	13	s.	s.	PROPN
admet-2988	669	14	lord	lord	PROPN
admet-2988	669	15	-	-	PUNCT
admet-2988	669	16	dufour	dufour	PROPN
admet-2988	669	17	,	,	PUNCT
admet-2988	669	18	j.c	j.c	PROPN
admet-2988	669	19	.	.	PROPN
admet-2988	669	20	currie	currie	PROPN
admet-2988	669	21	,	,	PUNCT
admet-2988	669	22	m.	m.	PROPN
admet-2988	669	23	iddir	iddir	PROPN
admet-2988	669	24	,	,	PUNCT
admet-2988	669	25	b.	b.	PROPN
admet-2988	669	26	annabi	annabi	PROPN
admet-2988	669	27	,	,	PUNCT
admet-2988	669	28	j.p	j.p	PROPN
admet-2988	669	29	.	.	PROPN
admet-2988	669	30	castaigne	castaigne	PROPN
admet-2988	669	31	,	,	PUNCT
admet-2988	669	32	j.e	j.e	PROPN
admet-2988	669	33	.	.	PROPN
admet-2988	669	34	lachowicz	lachowicz	PROPN
admet-2988	669	35	.	.	PUNCT
admet-2988	670	1	ang4043	ang4043	ADV
admet-2988	670	2	,	,	PUNCT
admet-2988	670	3	a	a	DET
admet-2988	670	4	novel	novel	ADJ
admet-2988	670	5	brain	brain	NOUN
admet-2988	670	6	-	-	PUNCT
admet-2988	670	7	penetrant	penetrant	NOUN
admet-2988	670	8	peptide	peptide	NOUN
admet-2988	670	9	-	-	PUNCT
admet-2988	670	10	mab	mab	NOUN
admet-2988	670	11	conjugate	conjugate	NOUN
admet-2988	670	12	,	,	PUNCT
admet-2988	670	13	is	be	AUX
admet-2988	670	14	efficacious	efficacious	ADJ
admet-2988	670	15	against	against	ADP
admet-2988	670	16	her2	her2	NOUN
admet-2988	670	17	-	-	PUNCT
admet-2988	670	18	positive	positive	ADJ
admet-2988	670	19	intracranial	intracranial	ADJ
admet-2988	670	20	tumors	tumor	NOUN
admet-2988	670	21	in	in	ADP
admet-2988	670	22	mice	mouse	NOUN
admet-2988	670	23	.	.	PUNCT
admet-2988	671	1	molecular	molecular	ADJ
admet-2988	671	2	cancer	cancer	NOUN
admet-2988	671	3	therapeutics	therapeutic	NOUN
admet-2988	671	4	14	14	NUM
admet-2988	671	5	(	(	PUNCT
admet-2988	671	6	2015	2015	NUM
admet-2988	671	7	)	)	PUNCT
admet-2988	671	8	129	129	NUM
admet-2988	671	9	-	-	SYM
admet-2988	671	10	140	140	NUM
admet-2988	671	11	.	.	PUNCT
admet-2988	672	1	https://doi.org/10.1158/1535-7163.mct-14-0399	https://doi.org/10.1158/1535-7163.mct-14-0399	PUNCT
admet-2988	673	1	[	[	X
admet-2988	673	2	93	93	X
admet-2988	673	3	]	]	X
admet-2988	673	4	a.r	a.r	PROPN
admet-2988	673	5	.	.	PROPN
admet-2988	673	6	neves	neves	PROPN
admet-2988	673	7	,	,	PUNCT
admet-2988	673	8	l.	l.	PROPN
admet-2988	673	9	van	van	PROPN
admet-2988	673	10	der	der	PROPN
admet-2988	673	11	putten	putten	VERB
admet-2988	673	12	,	,	PUNCT
admet-2988	673	13	j.f	j.f	PROPN
admet-2988	673	14	.	.	PROPN
admet-2988	673	15	queiroz	queiroz	PROPN
admet-2988	673	16	,	,	PUNCT
admet-2988	673	17	m.	m.	PROPN
admet-2988	673	18	pinheiro	pinheiro	PROPN
admet-2988	673	19	,	,	PUNCT
admet-2988	673	20	s.	s.	PROPN
admet-2988	673	21	reis	reis	PROPN
admet-2988	673	22	.	.	PUNCT
admet-2988	674	1	transferrin	transferrin	NOUN
admet-2988	674	2	-	-	PUNCT
admet-2988	674	3	functionalized	functionalize	VERB
admet-2988	674	4	lipid	lipid	NOUN
admet-2988	674	5	nanoparticles	nanoparticle	NOUN
admet-2988	674	6	for	for	ADP
admet-2988	674	7	curcumin	curcumin	NOUN
admet-2988	674	8	brain	brain	NOUN
admet-2988	674	9	delivery	delivery	NOUN
admet-2988	674	10	.	.	PUNCT
admet-2988	675	1	journal	journal	NOUN
admet-2988	675	2	of	of	ADP
admet-2988	675	3	biotechnology	biotechnology	NOUN
admet-2988	675	4	331	331	NUM
admet-2988	675	5	(	(	PUNCT
admet-2988	675	6	2021	2021	NUM
admet-2988	675	7	)	)	PUNCT
admet-2988	675	8	108	108	NUM
admet-2988	675	9	-	-	SYM
admet-2988	675	10	117	117	NUM
admet-2988	675	11	.	.	PUNCT
admet-2988	676	1	https://doi.org/10.1016/j.jbiotec.2021.03.010	https://doi.org/10.1016/j.jbiotec.2021.03.010	PROPN
admet-2988	676	2	[	[	X
admet-2988	676	3	94	94	X
admet-2988	676	4	]	]	PUNCT
admet-2988	676	5	s.	s.	PROPN
admet-2988	676	6	arora	arora	PROPN
admet-2988	676	7	,	,	PUNCT
admet-2988	676	8	j.	j.	PROPN
admet-2988	676	9	singh	singh	PROPN
admet-2988	676	10	.	.	PUNCT
admet-2988	677	1	in	in	ADP
admet-2988	677	2	vitro	vitro	X
admet-2988	677	3	and	and	CCONJ
admet-2988	677	4	in	in	ADP
admet-2988	677	5	vivo	vivo	ADJ
admet-2988	677	6	optimization	optimization	NOUN
admet-2988	677	7	of	of	ADP
admet-2988	677	8	liposomal	liposomal	ADJ
admet-2988	677	9	nanoparticles	nanoparticle	NOUN
admet-2988	677	10	based	base	VERB
admet-2988	677	11	brain	brain	NOUN
admet-2988	677	12	targeted	target	VERB
admet-2988	677	13	vgf	vgf	NOUN
admet-2988	677	14	gene	gene	NOUN
admet-2988	677	15	therapy	therapy	NOUN
admet-2988	677	16	.	.	PUNCT
admet-2988	678	1	international	international	ADJ
admet-2988	678	2	journal	journal	PROPN
admet-2988	678	3	of	of	ADP
admet-2988	678	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	678	5	608	608	NUM
admet-2988	678	6	(	(	PUNCT
admet-2988	678	7	2021	2021	NUM
admet-2988	678	8	)	)	PUNCT
admet-2988	678	9	121095	121095	NUM
admet-2988	678	10	.	.	PUNCT
admet-2988	679	1	https://doi.org/10.1016/j.ijpharm.2021.121095	https://doi.org/10.1016/j.ijpharm.2021.121095	PROPN
admet-2988	680	1	[	[	X
admet-2988	680	2	95	95	NUM
admet-2988	680	3	]	]	X
admet-2988	680	4	d.	d.	PROPN
admet-2988	680	5	bi	bi	PROPN
admet-2988	680	6	,	,	PUNCT
admet-2988	680	7	d.m	d.m	PROPN
admet-2988	680	8	.	.	PROPN
admet-2988	680	9	unthan	unthan	PROPN
admet-2988	680	10	,	,	PUNCT
admet-2988	680	11	l.	l.	PROPN
admet-2988	680	12	hu	hu	PROPN
admet-2988	680	13	,	,	PUNCT
admet-2988	680	14	j.	j.	PROPN
admet-2988	680	15	bussmann	bussmann	PROPN
admet-2988	680	16	,	,	PUNCT
admet-2988	680	17	k.	k.	PROPN
admet-2988	680	18	remaut	remaut	PROPN
admet-2988	680	19	,	,	PUNCT
admet-2988	680	20	m.	m.	NOUN
admet-2988	680	21	barz	barz	PROPN
admet-2988	680	22	,	,	PUNCT
admet-2988	680	23	h.	h.	PROPN
admet-2988	680	24	zhang	zhang	PROPN
admet-2988	680	25	.	.	PUNCT
admet-2988	680	26	polysarcosine	polysarcosine	NOUN
admet-2988	680	27	-	-	PUNCT
admet-2988	680	28	based	base	VERB
admet-2988	680	29	lipid	lipid	NOUN
admet-2988	680	30	formulations	formulation	NOUN
admet-2988	680	31	for	for	ADP
admet-2988	680	32	intracranial	intracranial	ADJ
admet-2988	680	33	delivery	delivery	NOUN
admet-2988	680	34	of	of	ADP
admet-2988	680	35	mrna	mrna	PROPN
admet-2988	680	36	.	.	PUNCT
admet-2988	680	37	journal	journal	PROPN
admet-2988	680	38	of	of	ADP
admet-2988	680	39	controlled	control	VERB
admet-2988	680	40	release	release	NOUN
admet-2988	680	41	356	356	NUM
admet-2988	680	42	(	(	PUNCT
admet-2988	680	43	2023	2023	NUM
admet-2988	680	44	)	)	PUNCT
admet-2988	680	45	1	1	NUM
admet-2988	680	46	-	-	SYM
admet-2988	680	47	13	13	NUM
admet-2988	680	48	.	.	PUNCT
admet-2988	681	1	https://doi.org/10.1016/j.jconrel.2023.02.021	https://doi.org/10.1016/j.jconrel.2023.02.021	PROPN
admet-2988	681	2	[	[	X
admet-2988	681	3	96	96	NUM
admet-2988	681	4	]	]	X
admet-2988	681	5	a.c	a.c	PROPN
admet-2988	681	6	.	.	PROPN
admet-2988	681	7	correia	correia	PROPN
admet-2988	681	8	,	,	PUNCT
admet-2988	681	9	a.r	a.r	PROPN
admet-2988	681	10	.	.	PROPN
admet-2988	681	11	monteiro	monteiro	PROPN
admet-2988	681	12	,	,	PUNCT
admet-2988	681	13	r.	r.	PROPN
admet-2988	681	14	silva	silva	PROPN
admet-2988	681	15	,	,	PUNCT
admet-2988	681	16	j.n	j.n	PROPN
admet-2988	681	17	.	.	PROPN
admet-2988	681	18	moreira	moreira	PROPN
admet-2988	681	19	,	,	PUNCT
admet-2988	681	20	j.m	j.m	PROPN
admet-2988	681	21	.	.	PROPN
admet-2988	681	22	sousa	sousa	PROPN
admet-2988	681	23	lobo	lobo	PROPN
admet-2988	681	24	,	,	PUNCT
admet-2988	681	25	a.c	a.c	PROPN
admet-2988	681	26	.	.	PROPN
admet-2988	681	27	silva	silva	PROPN
admet-2988	681	28	.	.	PUNCT
admet-2988	682	1	lipid	lipid	NOUN
admet-2988	682	2	nanoparticles	nanoparticle	NOUN
admet-2988	682	3	strategies	strategy	NOUN
admet-2988	682	4	to	to	PART
admet-2988	682	5	modify	modify	VERB
admet-2988	682	6	pharmacokinetics	pharmacokinetic	NOUN
admet-2988	682	7	of	of	ADP
admet-2988	682	8	central	central	ADJ
admet-2988	682	9	nervous	nervous	ADJ
admet-2988	682	10	system	system	NOUN
admet-2988	682	11	targeting	target	VERB
admet-2988	682	12	drugs	drug	NOUN
admet-2988	682	13	:	:	PUNCT
admet-2988	682	14	crossing	cross	VERB
admet-2988	682	15	or	or	CCONJ
admet-2988	682	16	circumventing	circumvent	VERB
admet-2988	682	17	the	the	DET
admet-2988	682	18	blood	blood	NOUN
admet-2988	682	19	-	-	PUNCT
admet-2988	682	20	brain	brain	NOUN
admet-2988	682	21	barrier	barrier	NOUN
admet-2988	682	22	(	(	PUNCT
admet-2988	682	23	bbb	bbb	NOUN
admet-2988	682	24	)	)	PUNCT
admet-2988	682	25	to	to	PART
admet-2988	682	26	manage	manage	VERB
admet-2988	682	27	neurological	neurological	ADJ
admet-2988	682	28	disorders	disorder	NOUN
admet-2988	682	29	.	.	PUNCT
admet-2988	683	1	advanced	advanced	ADJ
admet-2988	683	2	drug	drug	NOUN
admet-2988	683	3	delivery	delivery	NOUN
admet-2988	683	4	reviews	review	NOUN
admet-2988	683	5	189	189	NUM
admet-2988	683	6	(	(	PUNCT
admet-2988	683	7	2022	2022	NUM
admet-2988	683	8	)	)	PUNCT
admet-2988	683	9	114485	114485	NUM
admet-2988	683	10	.	.	PUNCT
admet-2988	684	1	https://doi.org/10.1016/j.addr.2022.114485	https://doi.org/10.1016/j.addr.2022.114485	PROPN
admet-2988	684	2	[	[	X
admet-2988	684	3	97	97	NUM
admet-2988	684	4	]	]	X
admet-2988	684	5	p.	p.	NOUN
admet-2988	684	6	khare	khare	PROPN
admet-2988	684	7	,	,	PUNCT
admet-2988	684	8	s.x	s.x	PROPN
admet-2988	684	9	.	.	PROPN
admet-2988	684	10	edgecomb	edgecomb	PROPN
admet-2988	684	11	,	,	PUNCT
admet-2988	684	12	c.m	c.m	PROPN
admet-2988	684	13	.	.	PROPN
admet-2988	684	14	hamadani	hamadani	PROPN
admet-2988	684	15	,	,	PUNCT
admet-2988	684	16	e.e.l	e.e.l	PROPN
admet-2988	684	17	.	.	PUNCT
admet-2988	684	18	tanner	tanner	NOUN
admet-2988	684	19	,	,	PUNCT
admet-2988	684	20	d.	d.	PROPN
admet-2988	684	21	s	s	PART
admet-2988	684	22	manickam	manickam	PROPN
admet-2988	684	23	.	.	PUNCT
admet-2988	685	1	lipid	lipid	PROPN
admet-2988	685	2	nanoparticlemediated	nanoparticlemediate	VERB
admet-2988	685	3	drug	drug	NOUN
admet-2988	685	4	delivery	delivery	NOUN
admet-2988	685	5	to	to	ADP
admet-2988	685	6	the	the	DET
admet-2988	685	7	brain	brain	NOUN
admet-2988	685	8	.	.	PUNCT
admet-2988	686	1	advanced	advanced	ADJ
admet-2988	686	2	drug	drug	NOUN
admet-2988	686	3	delivery	delivery	NOUN
admet-2988	686	4	reviews	review	NOUN
admet-2988	686	5	197	197	NUM
admet-2988	686	6	(	(	PUNCT
admet-2988	686	7	2023	2023	NUM
admet-2988	686	8	)	)	PUNCT
admet-2988	686	9	114861	114861	NUM
admet-2988	686	10	.	.	PUNCT
admet-2988	687	1	https://doi.org/10.1016/j.addr.2023.114861	https://doi.org/10.1016/j.addr.2023.114861	PROPN
admet-2988	688	1	[	[	X
admet-2988	688	2	98	98	NUM
admet-2988	688	3	]	]	X
admet-2988	688	4	a.g	a.g	PROPN
admet-2988	688	5	.	.	PROPN
admet-2988	688	6	niculescu	niculescu	PROPN
admet-2988	688	7	,	,	PUNCT
admet-2988	688	8	c.	c.	PROPN
admet-2988	688	9	chircov	chircov	PROPN
admet-2988	688	10	,	,	PUNCT
admet-2988	688	11	a.c	a.c	PROPN
admet-2988	688	12	.	.	PROPN
admet-2988	688	13	bîrcă	bîrcă	PROPN
admet-2988	688	14	,	,	PUNCT
admet-2988	688	15	a.m.	a.m.	PROPN
admet-2988	688	16	grumezescu	grumezescu	PROPN
admet-2988	688	17	.	.	PUNCT
admet-2988	689	1	nanomaterials	nanomaterial	NOUN
admet-2988	689	2	synthesis	synthesis	NOUN
admet-2988	689	3	through	through	ADP
admet-2988	689	4	microfluidic	microfluidic	ADJ
admet-2988	689	5	methods	method	NOUN
admet-2988	689	6	:	:	PUNCT
admet-2988	689	7	an	an	DET
admet-2988	689	8	updated	update	VERB
admet-2988	689	9	overview	overview	NOUN
admet-2988	689	10	.	.	PUNCT
admet-2988	690	1	nanomaterials	nanomaterial	NOUN
admet-2988	690	2	11	11	NUM
admet-2988	690	3	(	(	PUNCT
admet-2988	690	4	2021	2021	NUM
admet-2988	690	5	)	)	PUNCT
admet-2988	690	6	864	864	NUM
admet-2988	690	7	.	.	PUNCT
admet-2988	691	1	https://doi.org/10.3390/nano11040864	https://doi.org/10.3390/nano11040864	PROPN
admet-2988	691	2	.	.	PUNCT
admet-2988	692	1	[	[	X
admet-2988	692	2	99	99	NUM
admet-2988	692	3	]	]	X
admet-2988	692	4	r.	r.	PROPN
admet-2988	692	5	vargas	vargas	PROPN
admet-2988	692	6	,	,	PUNCT
admet-2988	692	7	m.	m.	PROPN
admet-2988	692	8	romero	romero	PROPN
admet-2988	692	9	,	,	PUNCT
admet-2988	692	10	t.	t.	PROPN
admet-2988	692	11	berasategui	berasategui	PROPN
admet-2988	692	12	,	,	PUNCT
admet-2988	692	13	d.a	d.a	PROPN
admet-2988	692	14	.	.	PROPN
admet-2988	692	15	narváez	narváez	PROPN
admet-2988	692	16	-	-	PUNCT
admet-2988	692	17	narváez	narváez	PROPN
admet-2988	692	18	,	,	PUNCT
admet-2988	692	19	p.	p.	PROPN
admet-2988	692	20	ramirez	ramirez	PROPN
admet-2988	692	21	,	,	PUNCT
admet-2988	692	22	a.	a.	PROPN
admet-2988	692	23	nardi	nardi	PROPN
admet-2988	692	24	-	-	PUNCT
admet-2988	692	25	ricart	ricart	PROPN
admet-2988	692	26	,	,	PUNCT
admet-2988	692	27	e.	e.	PROPN
admet-2988	692	28	garcíamontoya	garcíamontoya	PROPN
admet-2988	692	29	,	,	PUNCT
admet-2988	692	30	p.	p.	NOUN
admet-2988	692	31	pérez	pérez	NOUN
admet-2988	692	32	-	-	PUNCT
admet-2988	692	33	lozano	lozano	PROPN
admet-2988	692	34	,	,	PUNCT
admet-2988	692	35	j.m	j.m	PROPN
admet-2988	692	36	.	.	PROPN
admet-2988	692	37	suñe	suñe	PROPN
admet-2988	692	38	-	-	PUNCT
admet-2988	692	39	negre	negre	PROPN
admet-2988	692	40	,	,	PUNCT
admet-2988	692	41	c.	c.	PROPN
admet-2988	692	42	moreno	moreno	PROPN
admet-2988	692	43	-	-	PUNCT
admet-2988	692	44	castro	castro	PROPN
admet-2988	692	45	,	,	PUNCT
admet-2988	692	46	c.	c.	PROPN
admet-2988	692	47	hernández	hernández	PROPN
admet-2988	692	48	-	-	PUNCT
admet-2988	692	49	munain	munain	PROPN
admet-2988	692	50	,	,	PUNCT
admet-2988	692	51	c.	c.	PROPN
admet-2988	692	52	suñe	suñe	PROPN
admet-2988	692	53	,	,	PUNCT
admet-2988	692	54	m.	m.	NOUN
admet-2988	692	55	suñe	suñe	PROPN
admet-2988	692	56	-	-	PUNCT
admet-2988	692	57	pou	pou	PROPN
admet-2988	692	58	.	.	PROPN
admet-2988	692	59	dialysis	dialysis	NOUN
admet-2988	692	60	is	be	AUX
admet-2988	692	61	a	a	DET
admet-2988	692	62	key	key	ADJ
admet-2988	692	63	factor	factor	NOUN
admet-2988	692	64	modulating	modulate	VERB
admet-2988	692	65	interactions	interaction	NOUN
admet-2988	692	66	between	between	ADP
admet-2988	692	67	critical	critical	ADJ
admet-2988	692	68	process	process	NOUN
admet-2988	692	69	parameters	parameter	NOUN
admet-2988	692	70	during	during	ADP
admet-2988	692	71	the	the	DET
admet-2988	692	72	microfluidic	microfluidic	ADJ
admet-2988	692	73	preparation	preparation	NOUN
admet-2988	692	74	of	of	ADP
admet-2988	692	75	lipid	lipid	ADJ
admet-2988	692	76	nanoparticles	nanoparticle	NOUN
admet-2988	692	77	.	.	PUNCT
admet-2988	693	1	colloids	colloid	NOUN
admet-2988	693	2	and	and	CCONJ
admet-2988	693	3	interface	interface	NOUN
admet-2988	693	4	science	science	NOUN
admet-2988	693	5	communications	communication	NOUN
admet-2988	693	6	54	54	NUM
admet-2988	693	7	(	(	PUNCT
admet-2988	693	8	2023	2023	NUM
admet-2988	693	9	)	)	PUNCT
admet-2988	693	10	100709	100709	NUM
admet-2988	693	11	.	.	PUNCT
admet-2988	694	1	https://doi.org/10.1016/j.colcom.2023.100709	https://doi.org/10.1016/j.colcom.2023.100709	NOUN
admet-2988	694	2	.	.	PUNCT
admet-2988	695	1	[	[	X
admet-2988	695	2	100	100	NUM
admet-2988	695	3	]	]	PUNCT
admet-2988	695	4	a.	a.	NOUN
admet-2988	695	5	kadari	kadari	PROPN
admet-2988	695	6	,	,	PUNCT
admet-2988	695	7	d.	d.	PROPN
admet-2988	695	8	pooja	pooja	PROPN
admet-2988	695	9	,	,	PUNCT
admet-2988	695	10	r.h	r.h	PROPN
admet-2988	695	11	.	.	PROPN
admet-2988	695	12	gora	gora	PROPN
admet-2988	695	13	,	,	PUNCT
admet-2988	695	14	s.	s.	PROPN
admet-2988	695	15	gudem	gudem	PROPN
admet-2988	695	16	,	,	PUNCT
admet-2988	695	17	v.r.m	v.r.m	PROPN
admet-2988	695	18	.	.	PUNCT
admet-2988	695	19	kolapalli	kolapalli	PROPN
admet-2988	695	20	,	,	PUNCT
admet-2988	695	21	h.	h.	PROPN
admet-2988	695	22	kulhari	kulhari	PROPN
admet-2988	695	23	,	,	PUNCT
admet-2988	695	24	r.	r.	PROPN
admet-2988	695	25	sistla	sistla	PROPN
admet-2988	695	26	.	.	PUNCT
admet-2988	696	1	design	design	NOUN
admet-2988	696	2	of	of	ADP
admet-2988	696	3	multifunctional	multifunctional	ADJ
admet-2988	696	4	peptide	peptide	NOUN
admet-2988	696	5	collaborated	collaborate	VERB
admet-2988	696	6	and	and	CCONJ
admet-2988	696	7	docetaxel	docetaxel	NOUN
admet-2988	696	8	loaded	load	VERB
admet-2988	696	9	lipid	lipid	NOUN
admet-2988	696	10	nanoparticles	nanoparticle	NOUN
admet-2988	696	11	for	for	ADP
admet-2988	696	12	antiglioma	antiglioma	PROPN
admet-2988	696	13	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	ADJ
admet-2988	697	1	https://doi.org/10.1021/acsbiomaterials.3c01622	https://doi.org/10.1021/acsbiomaterials.3c01622	ADJ
admet-2988	697	2	https://doi.org/10.1016/j.ijpharm.2023.123656	https://doi.org/10.1016/j.ijpharm.2023.123656	ADJ
admet-2988	697	3	https://doi.org/10.1080/17435889.2024.2395234	https://doi.org/10.1080/17435889.2024.2395234	PROPN
admet-2988	697	4	https://doi.org/10.1016/j.cbpa.2017.04.019	https://doi.org/10.1016/j.cbpa.2017.04.019	PROPN
admet-2988	697	5	https://doi.org/10.1021/ja073522o	https://doi.org/10.1021/ja073522o	NOUN
admet-2988	697	6	https://doi.org/10.1039/d1ra08131d	https://doi.org/10.1039/d1ra08131d	PROPN
admet-2988	697	7	https://doi.org/10.1158/1535-7163.mct-14-0399	https://doi.org/10.1158/1535-7163.mct-14-0399	PROPN
admet-2988	697	8	https://doi.org/10.1016/j.jbiotec.2021.03.010	https://doi.org/10.1016/j.jbiotec.2021.03.010	PROPN
admet-2988	697	9	https://doi.org/10.1016/j.ijpharm.2021.121095	https://doi.org/10.1016/j.ijpharm.2021.121095	PROPN
admet-2988	697	10	https://doi.org/10.1016/j.jconrel.2023.02.021	https://doi.org/10.1016/j.jconrel.2023.02.021	VERB
admet-2988	697	11	https://doi.org/10.1016/j.addr.2022.114485	https://doi.org/10.1016/j.addr.2022.114485	PROPN
admet-2988	697	12	https://doi.org/10.1016/j.addr.2023.114861	https://doi.org/10.1016/j.addr.2023.114861	PROPN
admet-2988	697	13	https://doi.org/10.3390/nano11040864	https://doi.org/10.3390/nano11040864	PROPN
admet-2988	698	1	https://doi.org/10.1016/j.colcom.2023.100709	https://doi.org/10.1016/j.colcom.2023.100709	PROPN
admet-2988	698	2	r.	r.	PROPN
admet-2988	698	3	vargas	vargas	PROPN
admet-2988	698	4	et	et	PROPN
admet-2988	698	5	al	al	PROPN
admet-2988	698	6	.	.	PROPN
admet-2988	698	7	admet	admet	PROPN
admet-2988	698	8	&	&	CCONJ
admet-2988	698	9	dmpk	dmpk	PROPN
admet-2988	698	10	13(5	13(5	NUM
admet-2988	698	11	)	)	PUNCT
admet-2988	698	12	(	(	PUNCT
admet-2988	698	13	2025	2025	NUM
admet-2988	698	14	)	)	PUNCT
admet-2988	698	15	2988	2988	NUM
admet-2988	698	16	22	22	NUM
admet-2988	698	17	therapy	therapy	NOUN
admet-2988	698	18	.	.	PUNCT
admet-2988	699	1	european	european	PROPN
admet-2988	699	2	journal	journal	PROPN
admet-2988	699	3	of	of	ADP
admet-2988	699	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	699	5	and	and	CCONJ
admet-2988	699	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2988	699	7	132	132	NUM
admet-2988	699	8	(	(	PUNCT
admet-2988	699	9	2018	2018	NUM
admet-2988	699	10	)	)	PUNCT
admet-2988	699	11	168	168	NUM
admet-2988	699	12	-	-	SYM
admet-2988	699	13	179	179	NUM
admet-2988	699	14	.	.	PUNCT
admet-2988	700	1	https://doi.org/10.1016/j.ejpb.2018.09.012	https://doi.org/10.1016/j.ejpb.2018.09.012	NOUN
admet-2988	700	2	[	[	X
admet-2988	700	3	101	101	NUM
admet-2988	700	4	]	]	PUNCT
admet-2988	700	5	p.	p.	PROPN
admet-2988	700	6	ganesan	ganesan	PROPN
admet-2988	700	7	,	,	PUNCT
admet-2988	700	8	d.	d.	PROPN
admet-2988	700	9	narayanasamy	narayanasamy	NOUN
admet-2988	700	10	.	.	PUNCT
admet-2988	701	1	lipid	lipid	NOUN
admet-2988	701	2	nanoparticles	nanoparticle	NOUN
admet-2988	701	3	:	:	PUNCT
admet-2988	701	4	different	different	ADJ
admet-2988	701	5	preparation	preparation	NOUN
admet-2988	701	6	techniques	technique	NOUN
admet-2988	701	7	,	,	PUNCT
admet-2988	701	8	characterization	characterization	NOUN
admet-2988	701	9	,	,	PUNCT
admet-2988	701	10	hurdles	hurdle	NOUN
admet-2988	701	11	,	,	PUNCT
admet-2988	701	12	and	and	CCONJ
admet-2988	701	13	strategies	strategy	NOUN
admet-2988	701	14	for	for	ADP
admet-2988	701	15	the	the	DET
admet-2988	701	16	production	production	NOUN
admet-2988	701	17	of	of	ADP
admet-2988	701	18	solid	solid	ADJ
admet-2988	701	19	lipid	lipid	NOUN
admet-2988	701	20	nanoparticles	nanoparticle	NOUN
admet-2988	701	21	and	and	CCONJ
admet-2988	701	22	nanostructured	nanostructure	VERB
admet-2988	701	23	lipid	lipid	NOUN
admet-2988	701	24	carriers	carrier	NOUN
admet-2988	701	25	for	for	ADP
admet-2988	701	26	oral	oral	ADJ
admet-2988	701	27	drug	drug	NOUN
admet-2988	701	28	delivery	delivery	NOUN
admet-2988	701	29	.	.	PUNCT
admet-2988	702	1	sustainable	sustainable	ADJ
admet-2988	702	2	chemistry	chemistry	NOUN
admet-2988	702	3	and	and	CCONJ
admet-2988	702	4	pharmacy	pharmacy	NOUN
admet-2988	702	5	6	6	NUM
admet-2988	702	6	(	(	PUNCT
admet-2988	702	7	2017	2017	NUM
admet-2988	702	8	)	)	PUNCT
admet-2988	702	9	37	37	NUM
admet-2988	702	10	-	-	SYM
admet-2988	702	11	56	56	NUM
admet-2988	702	12	.	.	PUNCT
admet-2988	703	1	https://doi.org/10.1016/j.scp.2017.07.002	https://doi.org/10.1016/j.scp.2017.07.002	VERB
admet-2988	704	1	[	[	X
admet-2988	704	2	102	102	NUM
admet-2988	704	3	]	]	X
admet-2988	704	4	c.	c.	NOUN
admet-2988	704	5	ekhator	ekhator	NOUN
admet-2988	704	6	,	,	PUNCT
admet-2988	704	7	m.q	m.q	PROPN
admet-2988	704	8	.	.	PROPN
admet-2988	704	9	qureshi	qureshi	PROPN
admet-2988	704	10	,	,	PUNCT
admet-2988	704	11	a.w	a.w	PROPN
admet-2988	704	12	.	.	PROPN
admet-2988	704	13	zuberi	zuberi	PROPN
admet-2988	704	14	,	,	PUNCT
admet-2988	704	15	m.	m.	NOUN
admet-2988	704	16	hussain	hussain	PROPN
admet-2988	704	17	,	,	PUNCT
admet-2988	704	18	n.	n.	NOUN
admet-2988	704	19	sangroula	sangroula	PROPN
admet-2988	704	20	,	,	PUNCT
admet-2988	704	21	s.	s.	PROPN
admet-2988	704	22	yerra	yerra	PROPN
admet-2988	704	23	,	,	PUNCT
admet-2988	704	24	m.	m.	NOUN
admet-2988	704	25	devi	devi	PROPN
admet-2988	704	26	,	,	PUNCT
admet-2988	704	27	m.a	m.a	PROPN
admet-2988	704	28	.	.	PROPN
admet-2988	704	29	naseem	naseem	PROPN
admet-2988	704	30	,	,	PUNCT
admet-2988	704	31	s.b	s.b	PROPN
admet-2988	704	32	.	.	PROPN
admet-2988	704	33	bellegarde	bellegarde	PROPN
admet-2988	704	34	,	,	PUNCT
admet-2988	704	35	p.r	p.r	PROPN
admet-2988	704	36	.	.	PROPN
admet-2988	704	37	pendyala	pendyala	PROPN
admet-2988	704	38	.	.	PUNCT
admet-2988	705	1	advances	advance	NOUN
admet-2988	705	2	and	and	CCONJ
admet-2988	705	3	opportunities	opportunity	NOUN
admet-2988	705	4	in	in	ADP
admet-2988	705	5	nanoparticle	nanoparticle	NOUN
admet-2988	705	6	drug	drug	NOUN
admet-2988	705	7	delivery	delivery	NOUN
admet-2988	705	8	for	for	ADP
admet-2988	705	9	central	central	ADJ
admet-2988	705	10	nervous	nervous	ADJ
admet-2988	705	11	system	system	NOUN
admet-2988	705	12	disorders	disorder	NOUN
admet-2988	705	13	:	:	PUNCT
admet-2988	705	14	a	a	DET
admet-2988	705	15	review	review	NOUN
admet-2988	705	16	of	of	ADP
admet-2988	705	17	current	current	ADJ
admet-2988	705	18	advances	advance	NOUN
admet-2988	705	19	.	.	PUNCT
admet-2988	706	1	cureus	cureus	NOUN
admet-2988	706	2	15	15	NUM
admet-2988	706	3	(	(	PUNCT
admet-2988	706	4	2023	2023	NUM
admet-2988	706	5	)	)	PUNCT
admet-2988	706	6	e44302	e44302	PROPN
admet-2988	706	7	.	.	PUNCT
admet-2988	706	8	https://doi.org/10.7759/cureus.44302	https://doi.org/10.7759/cureus.44302	PROPN
admet-2988	707	1	[	[	X
admet-2988	707	2	103	103	NUM
admet-2988	707	3	]	]	X
admet-2988	707	4	c.	c.	PROPN
admet-2988	707	5	ferraris	ferraris	PROPN
admet-2988	707	6	,	,	PUNCT
admet-2988	707	7	r.	r.	PROPN
admet-2988	707	8	cavalli	cavalli	PROPN
admet-2988	707	9	,	,	PUNCT
admet-2988	707	10	p.p	p.p	PROPN
admet-2988	707	11	.	.	PROPN
admet-2988	707	12	panciani	panciani	PROPN
admet-2988	707	13	,	,	PUNCT
admet-2988	707	14	l.	l.	PROPN
admet-2988	707	15	battaglia	battaglia	PROPN
admet-2988	707	16	.	.	PUNCT
admet-2988	708	1	overcoming	overcome	VERB
admet-2988	708	2	the	the	DET
admet-2988	708	3	blood	blood	NOUN
admet-2988	708	4	-	-	PUNCT
admet-2988	708	5	brain	brain	NOUN
admet-2988	708	6	barrier	barrier	NOUN
admet-2988	708	7	:	:	PUNCT
admet-2988	708	8	successes	success	NOUN
admet-2988	708	9	and	and	CCONJ
admet-2988	708	10	challenges	challenge	NOUN
admet-2988	708	11	in	in	ADP
admet-2988	708	12	developing	develop	VERB
admet-2988	708	13	nanoparticle	nanoparticle	NOUN
admet-2988	708	14	-	-	PUNCT
admet-2988	708	15	mediated	mediate	VERB
admet-2988	708	16	drug	drug	NOUN
admet-2988	708	17	delivery	delivery	NOUN
admet-2988	708	18	systems	system	NOUN
admet-2988	708	19	for	for	ADP
admet-2988	708	20	the	the	DET
admet-2988	708	21	treatment	treatment	NOUN
admet-2988	708	22	of	of	ADP
admet-2988	708	23	brain	brain	NOUN
admet-2988	708	24	tumours	tumour	NOUN
admet-2988	708	25	.	.	PUNCT
admet-2988	709	1	international	international	ADJ
admet-2988	709	2	journal	journal	PROPN
admet-2988	709	3	of	of	ADP
admet-2988	709	4	nanomedicine	nanomedicine	NOUN
admet-2988	709	5	15	15	NUM
admet-2988	709	6	(	(	PUNCT
admet-2988	709	7	2020	2020	NUM
admet-2988	709	8	)	)	PUNCT
admet-2988	709	9	2999	2999	NUM
admet-2988	709	10	-	-	SYM
admet-2988	709	11	3022	3022	NUM
admet-2988	709	12	.	.	PUNCT
admet-2988	710	1	https://doi.org/10.2147/ijn.s231479	https://doi.org/10.2147/ijn.s231479	X
admet-2988	711	1	[	[	X
admet-2988	711	2	104	104	X
admet-2988	711	3	]	]	X
admet-2988	711	4	c.	c.	PROPN
admet-2988	711	5	pucci	pucci	PROPN
admet-2988	711	6	,	,	PUNCT
admet-2988	711	7	d.	d.	PROPN
admet-2988	711	8	de	de	PROPN
admet-2988	711	9	pasquale	pasquale	PROPN
admet-2988	711	10	,	,	PUNCT
admet-2988	711	11	a.	a.	PROPN
admet-2988	711	12	marino	marino	PROPN
admet-2988	711	13	,	,	PUNCT
admet-2988	711	14	c.	c.	PROPN
admet-2988	711	15	martinelli	martinelli	PROPN
admet-2988	711	16	,	,	PUNCT
admet-2988	711	17	s.	s.	PROPN
admet-2988	711	18	lauciello	lauciello	PROPN
admet-2988	711	19	,	,	PUNCT
admet-2988	711	20	g.	g.	PROPN
admet-2988	711	21	ciofani	ciofani	PROPN
admet-2988	711	22	.	.	PUNCT
admet-2988	712	1	hybrid	hybrid	PROPN
admet-2988	712	2	magnetic	magnetic	PROPN
admet-2988	712	3	nanovectors	nanovector	NOUN
admet-2988	712	4	promote	promote	VERB
admet-2988	712	5	selective	selective	ADJ
admet-2988	712	6	glioblastoma	glioblastoma	NOUN
admet-2988	712	7	cell	cell	NOUN
admet-2988	712	8	death	death	NOUN
admet-2988	712	9	through	through	ADP
admet-2988	712	10	a	a	DET
admet-2988	712	11	combined	combine	VERB
admet-2988	712	12	effect	effect	NOUN
admet-2988	712	13	of	of	ADP
admet-2988	712	14	lysosomal	lysosomal	ADJ
admet-2988	712	15	membrane	membrane	NOUN
admet-2988	712	16	permeabilization	permeabilization	NOUN
admet-2988	712	17	and	and	CCONJ
admet-2988	712	18	chemotherapy	chemotherapy	NOUN
admet-2988	712	19	.	.	PUNCT
admet-2988	713	1	acs	acs	PROPN
admet-2988	713	2	applied	apply	VERB
admet-2988	713	3	materials	material	NOUN
admet-2988	713	4	and	and	CCONJ
admet-2988	713	5	interfaces	interface	NOUN
admet-2988	713	6	12	12	NUM
admet-2988	713	7	(	(	PUNCT
admet-2988	713	8	2020	2020	NUM
admet-2988	713	9	)	)	PUNCT
admet-2988	713	10	29037	29037	NUM
admet-2988	713	11	-	-	SYM
admet-2988	713	12	29055	29055	NUM
admet-2988	713	13	.	.	PUNCT
admet-2988	714	1	https://doi.org/10.1021/acsami.0c05556	https://doi.org/10.1021/acsami.0c05556	NOUN
admet-2988	714	2	[	[	X
admet-2988	714	3	105	105	NUM
admet-2988	714	4	]	]	X
admet-2988	714	5	i.	i.	NOUN
admet-2988	714	6	arduino	arduino	PROPN
admet-2988	714	7	,	,	PUNCT
admet-2988	714	8	r.m	r.m	PROPN
admet-2988	714	9	.	.	PROPN
admet-2988	714	10	iacobazzi	iacobazzi	PROPN
admet-2988	714	11	,	,	PUNCT
admet-2988	714	12	c.	c.	PROPN
admet-2988	714	13	riganti	riganti	PROPN
admet-2988	714	14	,	,	PUNCT
admet-2988	714	15	a.a	a.a	PROPN
admet-2988	714	16	.	.	PROPN
admet-2988	714	17	lopedota	lopedota	PROPN
admet-2988	714	18	,	,	PUNCT
admet-2988	714	19	m.g	m.g	PROPN
admet-2988	714	20	.	.	PROPN
admet-2988	714	21	perrone	perrone	PROPN
admet-2988	714	22	,	,	PUNCT
admet-2988	714	23	a.	a.	NOUN
admet-2988	714	24	lopalco	lopalco	PROPN
admet-2988	714	25	,	,	PUNCT
admet-2988	714	26	a.	a.	NOUN
admet-2988	714	27	cutrignelli	cutrignelli	PROPN
admet-2988	714	28	,	,	PUNCT
admet-2988	714	29	m.	m.	NOUN
admet-2988	714	30	cantore	cantore	PROPN
admet-2988	714	31	,	,	PUNCT
admet-2988	714	32	v.	v.	ADP
admet-2988	714	33	laquintana	laquintana	PROPN
admet-2988	714	34	,	,	PUNCT
admet-2988	714	35	m.	m.	NOUN
admet-2988	714	36	franco	franco	PROPN
admet-2988	714	37	,	,	PUNCT
admet-2988	714	38	n.a	n.a	PROPN
admet-2988	714	39	.	.	PROPN
admet-2988	714	40	colabufo	colabufo	PROPN
admet-2988	714	41	,	,	PUNCT
admet-2988	714	42	g.	g.	PROPN
admet-2988	714	43	luurtsema	luurtsema	PROPN
admet-2988	714	44	,	,	PUNCT
admet-2988	714	45	m.	m.	NOUN
admet-2988	714	46	contino	contino	PROPN
admet-2988	714	47	,	,	PUNCT
admet-2988	714	48	n.	n.	PROPN
admet-2988	714	49	denora	denora	PROPN
admet-2988	714	50	.	.	PUNCT
admet-2988	715	1	induced	induce	VERB
admet-2988	715	2	expression	expression	NOUN
admet-2988	715	3	of	of	ADP
admet-2988	715	4	p	p	NOUN
admet-2988	715	5	-	-	PUNCT
admet-2988	715	6	gp	gp	NOUN
admet-2988	715	7	and	and	CCONJ
admet-2988	715	8	bcrp	bcrp	PROPN
admet-2988	715	9	transporters	transporter	NOUN
admet-2988	715	10	on	on	ADP
admet-2988	715	11	brain	brain	NOUN
admet-2988	715	12	endothelial	endothelial	ADJ
admet-2988	715	13	cells	cell	NOUN
admet-2988	715	14	using	use	VERB
admet-2988	715	15	transferrin	transferrin	NOUN
admet-2988	715	16	functionalized	functionalize	VERB
admet-2988	715	17	nanostructured	nanostructure	VERB
admet-2988	715	18	lipid	lipid	NOUN
admet-2988	715	19	carriers	carrier	NOUN
admet-2988	715	20	:	:	PUNCT
admet-2988	715	21	a	a	DET
admet-2988	715	22	first	first	ADJ
admet-2988	715	23	step	step	NOUN
admet-2988	715	24	of	of	ADP
admet-2988	715	25	a	a	DET
admet-2988	715	26	potential	potential	ADJ
admet-2988	715	27	strategy	strategy	NOUN
admet-2988	715	28	for	for	ADP
admet-2988	715	29	the	the	DET
admet-2988	715	30	treatment	treatment	NOUN
admet-2988	715	31	of	of	ADP
admet-2988	715	32	alzheimer	alzheimer	PROPN
admet-2988	715	33	’s	’s	PART
admet-2988	715	34	disease	disease	NOUN
admet-2988	715	35	.	.	PUNCT
admet-2988	716	1	international	international	ADJ
admet-2988	716	2	journal	journal	PROPN
admet-2988	716	3	of	of	ADP
admet-2988	716	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	716	5	591	591	NUM
admet-2988	716	6	(	(	PUNCT
admet-2988	716	7	2020	2020	NUM
admet-2988	716	8	)	)	PUNCT
admet-2988	716	9	120011	120011	NUM
admet-2988	716	10	.	.	PUNCT
admet-2988	717	1	https://doi.org/10.1016/j.ijpharm.2020.120011	https://doi.org/10.1016/j.ijpharm.2020.120011	PROPN
admet-2988	717	2	[	[	X
admet-2988	717	3	106	106	X
admet-2988	717	4	]	]	X
admet-2988	717	5	e.m	e.m	PROPN
admet-2988	717	6	.	.	PROPN
admet-2988	717	7	mcconnell	mcconnell	PROPN
admet-2988	717	8	,	,	PUNCT
admet-2988	717	9	k.	k.	PROPN
admet-2988	717	10	ventura	ventura	PROPN
admet-2988	717	11	,	,	PUNCT
admet-2988	717	12	z.	z.	PROPN
admet-2988	717	13	dwyer	dwyer	PROPN
admet-2988	717	14	,	,	PUNCT
admet-2988	717	15	v.	v.	ADP
admet-2988	717	16	hunt	hunt	PROPN
admet-2988	717	17	,	,	PUNCT
admet-2988	717	18	a.	a.	NOUN
admet-2988	717	19	koudrina	koudrina	PROPN
admet-2988	717	20	,	,	PUNCT
admet-2988	717	21	m.r	m.r	PROPN
admet-2988	717	22	.	.	PROPN
admet-2988	717	23	holahan	holahan	PROPN
admet-2988	717	24	,	,	PUNCT
admet-2988	717	25	m.c	m.c	PROPN
admet-2988	717	26	.	.	PROPN
admet-2988	717	27	derosa	derosa	PROPN
admet-2988	717	28	.	.	PUNCT
admet-2988	718	1	in	in	ADP
admet-2988	718	2	vivo	vivo	ADJ
admet-2988	718	3	use	use	NOUN
admet-2988	718	4	of	of	ADP
admet-2988	718	5	a	a	DET
admet-2988	718	6	multi	multi	ADJ
admet-2988	718	7	-	-	ADJ
admet-2988	718	8	dna	dna	ADJ
admet-2988	718	9	aptamer	aptamer	NOUN
admet-2988	718	10	-	-	PUNCT
admet-2988	718	11	based	base	VERB
admet-2988	718	12	payload	payload	NOUN
admet-2988	718	13	/	/	SYM
admet-2988	718	14	targeting	target	VERB
admet-2988	718	15	system	system	NOUN
admet-2988	718	16	to	to	PART
admet-2988	718	17	study	study	VERB
admet-2988	718	18	dopamine	dopamine	NOUN
admet-2988	718	19	dysregulation	dysregulation	NOUN
admet-2988	718	20	in	in	ADP
admet-2988	718	21	the	the	DET
admet-2988	718	22	central	central	ADJ
admet-2988	718	23	nervous	nervous	ADJ
admet-2988	718	24	system	system	NOUN
admet-2988	718	25	.	.	PUNCT
admet-2988	719	1	acs	acs	PROPN
admet-2988	719	2	chemical	chemical	PROPN
admet-2988	719	3	neuroscience	neuroscience	NOUN
admet-2988	719	4	10	10	NUM
admet-2988	719	5	(	(	PUNCT
admet-2988	719	6	2019	2019	NUM
admet-2988	719	7	)	)	PUNCT
admet-2988	719	8	371	371	NUM
admet-2988	719	9	-	-	SYM
admet-2988	719	10	383	383	NUM
admet-2988	719	11	.	.	PUNCT
admet-2988	720	1	https://doi.org/10.1021/acschemneuro.8b00292	https://doi.org/10.1021/acschemneuro.8b00292	NOUN
admet-2988	721	1	[	[	X
admet-2988	721	2	107	107	NUM
admet-2988	721	3	]	]	PUNCT
admet-2988	721	4	f.	f.	PROPN
admet-2988	721	5	ma	ma	PROPN
admet-2988	721	6	,	,	PUNCT
admet-2988	721	7	l.	l.	PROPN
admet-2988	721	8	yang	yang	PROPN
admet-2988	721	9	,	,	PUNCT
admet-2988	721	10	z.	z.	PROPN
admet-2988	721	11	sun	sun	PROPN
admet-2988	721	12	,	,	PUNCT
admet-2988	721	13	j.	j.	PROPN
admet-2988	721	14	chen	chen	PROPN
admet-2988	721	15	,	,	PUNCT
admet-2988	721	16	x.	x.	PROPN
admet-2988	721	17	rui	rui	PROPN
admet-2988	721	18	,	,	PUNCT
admet-2988	721	19	z.	z.	PROPN
admet-2988	721	20	glass	glass	PROPN
admet-2988	721	21	,	,	PUNCT
admet-2988	721	22	q.	q.	PROPN
admet-2988	721	23	xu	xu	PROPN
admet-2988	721	24	.	.	PUNCT
admet-2988	722	1	neurotransmitter	neurotransmitter	NOUN
admet-2988	722	2	-	-	PUNCT
admet-2988	722	3	derived	derive	VERB
admet-2988	722	4	lipidoids	lipidoid	NOUN
admet-2988	722	5	(	(	PUNCT
admet-2988	722	6	ntlipidoids	ntlipidoid	NOUN
admet-2988	722	7	)	)	PUNCT
admet-2988	722	8	for	for	ADP
admet-2988	722	9	enhanced	enhanced	ADJ
admet-2988	722	10	brain	brain	NOUN
admet-2988	722	11	delivery	delivery	NOUN
admet-2988	722	12	through	through	ADP
admet-2988	722	13	intravenous	intravenous	ADJ
admet-2988	722	14	injection	injection	NOUN
admet-2988	722	15	.	.	PUNCT
admet-2988	723	1	science	science	NOUN
admet-2988	723	2	advances	advance	VERB
admet-2988	723	3	6	6	NUM
admet-2988	723	4	(	(	PUNCT
admet-2988	723	5	2020	2020	NUM
admet-2988	723	6	)	)	PUNCT
admet-2988	723	7	eabb4429	eabb4429	PROPN
admet-2988	723	8	.	.	PUNCT
admet-2988	724	1	https://doi.org/10.1126/sciadv.abb4429	https://doi.org/10.1126/sciadv.abb4429	PROPN
admet-2988	724	2	[	[	X
admet-2988	724	3	108	108	NUM
admet-2988	724	4	]	]	PUNCT
admet-2988	724	5	l.	l.	PROPN
admet-2988	724	6	wu	wu	PROPN
admet-2988	724	7	,	,	PUNCT
admet-2988	724	8	w.	w.	PROPN
admet-2988	724	9	huang	huang	PROPN
admet-2988	724	10	,	,	PUNCT
admet-2988	724	11	k.	k.	PROPN
admet-2988	724	12	peng	peng	PROPN
admet-2988	724	13	,	,	PUNCT
admet-2988	724	14	y.	y.	PROPN
admet-2988	724	15	wang	wang	PROPN
admet-2988	724	16	,	,	PUNCT
admet-2988	724	17	q.	q.	PROPN
admet-2988	724	18	chen	chen	PROPN
admet-2988	724	19	,	,	PUNCT
admet-2988	724	20	b.	b.	PROPN
admet-2988	724	21	lu	lu	PROPN
admet-2988	724	22	.	.	PUNCT
admet-2988	725	1	enhancing	enhance	VERB
admet-2988	725	2	the	the	DET
admet-2988	725	3	stability	stability	NOUN
admet-2988	725	4	,	,	PUNCT
admet-2988	725	5	bbb	bbb	NOUN
admet-2988	725	6	permeability	permeability	NOUN
admet-2988	725	7	and	and	CCONJ
admet-2988	725	8	neuroprotective	neuroprotective	ADJ
admet-2988	725	9	activity	activity	NOUN
admet-2988	725	10	of	of	ADP
admet-2988	725	11	verbascoside	verbascoside	NOUN
admet-2988	725	12	in	in	ADP
admet-2988	725	13	vitro	vitro	X
admet-2988	725	14	using	use	VERB
admet-2988	725	15	lipid	lipid	NOUN
admet-2988	725	16	nanocapsules	nanocapsule	NOUN
admet-2988	725	17	in	in	ADP
admet-2988	725	18	combination	combination	NOUN
admet-2988	725	19	with	with	ADP
admet-2988	725	20	menthol	menthol	NOUN
admet-2988	725	21	.	.	PUNCT
admet-2988	726	1	food	food	NOUN
admet-2988	726	2	chemistry	chemistry	NOUN
admet-2988	726	3	414	414	NUM
admet-2988	726	4	(	(	PUNCT
admet-2988	726	5	2023	2023	NUM
admet-2988	726	6	)	)	PUNCT
admet-2988	726	7	135682	135682	NUM
admet-2988	726	8	.	.	PUNCT
admet-2988	727	1	https://doi.org/10.1016/j.foodchem.2023.135682	https://doi.org/10.1016/j.foodchem.2023.135682	ADJ
admet-2988	727	2	[	[	X
admet-2988	727	3	109	109	NUM
admet-2988	727	4	]	]	X
admet-2988	727	5	m.r	m.r	PROPN
admet-2988	727	6	.	.	PROPN
admet-2988	727	7	vijayakumar	vijayakumar	PROPN
admet-2988	727	8	,	,	PUNCT
admet-2988	727	9	k.y	k.y	PROPN
admet-2988	727	10	.	.	PROPN
admet-2988	727	11	vajanthri	vajanthri	PROPN
admet-2988	727	12	,	,	PUNCT
admet-2988	727	13	c.k	c.k	PROPN
admet-2988	727	14	.	.	PROPN
admet-2988	727	15	balavigneswaran	balavigneswaran	PROPN
admet-2988	727	16	,	,	PUNCT
admet-2988	727	17	s.k	s.k	PROPN
admet-2988	727	18	.	.	PROPN
admet-2988	727	19	mahto	mahto	PROPN
admet-2988	727	20	,	,	PUNCT
admet-2988	727	21	n.	n.	PROPN
admet-2988	727	22	mishra	mishra	PROPN
admet-2988	727	23	,	,	PUNCT
admet-2988	727	24	m.s	m.s	PROPN
admet-2988	727	25	.	.	PROPN
admet-2988	727	26	muthu	muthu	PROPN
admet-2988	727	27	,	,	PUNCT
admet-2988	727	28	s.	s.	PROPN
admet-2988	727	29	singh	singh	PROPN
admet-2988	727	30	.	.	PUNCT
admet-2988	728	1	pharmacokinetics	pharmacokinetic	NOUN
admet-2988	728	2	,	,	PUNCT
admet-2988	728	3	biodistribution	biodistribution	NOUN
admet-2988	728	4	,	,	PUNCT
admet-2988	728	5	in	in	ADP
admet-2988	728	6	vitro	vitro	X
admet-2988	728	7	cytotoxicity	cytotoxicity	NOUN
admet-2988	728	8	and	and	CCONJ
admet-2988	728	9	biocompatibility	biocompatibility	NOUN
admet-2988	728	10	of	of	ADP
admet-2988	728	11	vitamin	vitamin	NOUN
admet-2988	728	12	e	e	NOUN
admet-2988	728	13	tpgs	tpgs	NOUN
admet-2988	728	14	coated	coated	ADJ
admet-2988	728	15	trans	tran	NOUN
admet-2988	728	16	resveratrol	resveratrol	NOUN
admet-2988	728	17	liposomes	liposome	NOUN
admet-2988	728	18	.	.	PUNCT
admet-2988	729	1	colloids	colloid	NOUN
admet-2988	729	2	and	and	CCONJ
admet-2988	729	3	surfaces	surface	NOUN
admet-2988	729	4	b	b	NUM
admet-2988	729	5	:	:	PUNCT
admet-2988	729	6	biointerfaces	biointerface	NOUN
admet-2988	729	7	145	145	NUM
admet-2988	729	8	(	(	PUNCT
admet-2988	729	9	2016	2016	NUM
admet-2988	729	10	)	)	PUNCT
admet-2988	729	11	479	479	NUM
admet-2988	729	12	-	-	SYM
admet-2988	729	13	491	491	NUM
admet-2988	729	14	.	.	PUNCT
admet-2988	730	1	https://doi.org/10.1016/j.colsurfb.2016.05.037	https://doi.org/10.1016/j.colsurfb.2016.05.037	NOUN
admet-2988	730	2	[	[	X
admet-2988	730	3	110	110	NUM
admet-2988	730	4	]	]	PUNCT
admet-2988	730	5	a.	a.	NOUN
admet-2988	730	6	falcão	falcão	PROPN
admet-2988	730	7	,	,	PUNCT
admet-2988	730	8	j.	j.	PROPN
admet-2988	730	9	sousa	sousa	PROPN
admet-2988	730	10	,	,	PUNCT
admet-2988	730	11	a.	a.	PROPN
admet-2988	730	12	pais	pais	PROPN
admet-2988	730	13	,	,	PUNCT
admet-2988	730	14	c.	c.	PROPN
admet-2988	730	15	vitorino	vitorino	PROPN
admet-2988	730	16	.	.	PUNCT
admet-2988	731	1	peptide	peptide	NOUN
admet-2988	731	2	-	-	PUNCT
admet-2988	731	3	lipid	lipid	NOUN
admet-2988	731	4	nanoconstructs	nanoconstructs	PROPN
admet-2988	731	5	act	act	PROPN
admet-2988	731	6	site	site	NOUN
admet-2988	731	7	-	-	PUNCT
admet-2988	731	8	specifically	specifically	ADV
admet-2988	731	9	towards	towards	ADP
admet-2988	731	10	glioblastoma	glioblastoma	NOUN
admet-2988	731	11	growth	growth	NOUN
admet-2988	731	12	impairment	impairment	NOUN
admet-2988	731	13	.	.	PUNCT
admet-2988	732	1	european	european	PROPN
admet-2988	732	2	journal	journal	PROPN
admet-2988	732	3	of	of	ADP
admet-2988	732	4	pharmaceutics	pharmaceutic	NOUN
admet-2988	732	5	and	and	CCONJ
admet-2988	732	6	biopharmaceutics	biopharmaceutic	NOUN
admet-2988	732	7	155	155	NUM
admet-2988	732	8	(	(	PUNCT
admet-2988	732	9	2020	2020	NUM
admet-2988	732	10	)	)	PUNCT
admet-2988	732	11	177	177	NUM
admet-2988	732	12	-	-	SYM
admet-2988	732	13	189	189	NUM
admet-2988	732	14	.	.	PUNCT
admet-2988	733	1	https://doi.org/10.1016/j.ejpb.2020.08.015	https://doi.org/10.1016/j.ejpb.2020.08.015	PRON
admet-2988	734	1	[	[	X
admet-2988	734	2	111	111	NUM
admet-2988	734	3	]	]	X
admet-2988	734	4	y.c	y.c	PROPN
admet-2988	734	5	.	.	PROPN
admet-2988	734	6	kuo	kuo	PROPN
admet-2988	734	7	,	,	PUNCT
admet-2988	734	8	c.c	c.c	PROPN
admet-2988	734	9	.	.	PROPN
admet-2988	734	10	hsu	hsu	PROPN
admet-2988	734	11	.	.	PUNCT
admet-2988	735	1	anti	anti	ADJ
admet-2988	735	2	-	-	ADJ
admet-2988	735	3	melanotransferrin	melanotransferrin	NOUN
admet-2988	735	4	and	and	CCONJ
admet-2988	735	5	apolipoprotein	apolipoprotein	ADJ
admet-2988	735	6	e	e	PROPN
admet-2988	735	7	on	on	ADP
admet-2988	735	8	doxorubicin	doxorubicin	PROPN
admet-2988	735	9	-	-	PUNCT
admet-2988	735	10	loaded	load	VERB
admet-2988	735	11	cationic	cationic	ADJ
admet-2988	735	12	solid	solid	ADJ
admet-2988	735	13	lipid	lipid	NOUN
admet-2988	735	14	nanoparticles	nanoparticle	NOUN
admet-2988	735	15	for	for	ADP
admet-2988	735	16	pharmacotherapy	pharmacotherapy	NOUN
admet-2988	735	17	of	of	ADP
admet-2988	735	18	glioblastoma	glioblastoma	NOUN
admet-2988	735	19	multiforme	multiforme	NOUN
admet-2988	735	20	.	.	PUNCT
admet-2988	736	1	journal	journal	NOUN
admet-2988	736	2	of	of	ADP
admet-2988	736	3	the	the	DET
admet-2988	736	4	taiwan	taiwan	PROPN
admet-2988	736	5	institute	institute	PROPN
admet-2988	736	6	of	of	ADP
admet-2988	736	7	chemical	chemical	PROPN
admet-2988	736	8	engineers	engineer	NOUN
admet-2988	736	9	77	77	NUM
admet-2988	736	10	(	(	PUNCT
admet-2988	736	11	2017	2017	NUM
admet-2988	736	12	)	)	PUNCT
admet-2988	736	13	10	10	NUM
admet-2988	736	14	-	-	SYM
admet-2988	736	15	20	20	NUM
admet-2988	736	16	.	.	PUNCT
admet-2988	737	1	https://doi.org/10.1016/j.jtice.2017.04.026	https://doi.org/10.1016/j.jtice.2017.04.026	PROPN
admet-2988	737	2	[	[	X
admet-2988	737	3	112	112	NUM
admet-2988	737	4	]	]	X
admet-2988	737	5	r.m	r.m	PROPN
admet-2988	737	6	.	.	PROPN
admet-2988	737	7	ray	ray	PROPN
admet-2988	737	8	,	,	PUNCT
admet-2988	737	9	a.h	a.h	PROPN
admet-2988	737	10	.	.	PROPN
admet-2988	737	11	hansen	hansen	PROPN
admet-2988	737	12	,	,	PUNCT
admet-2988	737	13	m.	m.	PROPN
admet-2988	737	14	taskova	taskova	PROPN
admet-2988	737	15	,	,	PUNCT
admet-2988	737	16	b.	b.	PROPN
admet-2988	737	17	jandl	jandl	PROPN
admet-2988	737	18	,	,	PUNCT
admet-2988	737	19	j.	j.	PROPN
admet-2988	737	20	hansen	hansen	PROPN
admet-2988	737	21	,	,	PUNCT
admet-2988	737	22	c.	c.	PROPN
admet-2988	737	23	soemardy	soemardy	PROPN
admet-2988	737	24	,	,	PUNCT
admet-2988	737	25	k.	k.	PROPN
admet-2988	737	26	v.	v.	PROPN
admet-2988	737	27	morris	morris	PROPN
admet-2988	737	28	,	,	PUNCT
admet-2988	737	29	k.	k.	PROPN
admet-2988	737	30	astakhova	astakhova	PROPN
admet-2988	737	31	.	.	PUNCT
admet-2988	738	1	enhanced	enhanced	ADJ
admet-2988	738	2	target	target	NOUN
admet-2988	738	3	cell	cell	NOUN
admet-2988	738	4	specificity	specificity	NOUN
admet-2988	738	5	and	and	CCONJ
admet-2988	738	6	uptake	uptake	NOUN
admet-2988	738	7	of	of	ADP
admet-2988	738	8	lipid	lipid	ADJ
admet-2988	738	9	nanoparticles	nanoparticle	NOUN
admet-2988	738	10	using	use	VERB
admet-2988	738	11	rna	rna	NOUN
admet-2988	738	12	aptamers	aptamer	NOUN
admet-2988	738	13	and	and	CCONJ
admet-2988	738	14	peptides	peptide	NOUN
admet-2988	738	15	.	.	PUNCT
admet-2988	739	1	beilstein	beilstein	ADJ
admet-2988	739	2	journal	journal	PROPN
admet-2988	739	3	of	of	ADP
admet-2988	739	4	organic	organic	ADJ
admet-2988	739	5	chemistry	chemistry	NOUN
admet-2988	739	6	17	17	NUM
admet-2988	739	7	(	(	PUNCT
admet-2988	739	8	2021	2021	NUM
admet-2988	739	9	)	)	PUNCT
admet-2988	739	10	891	891	NUM
admet-2988	739	11	-	-	SYM
admet-2988	739	12	907	907	NUM
admet-2988	739	13	.	.	PUNCT
admet-2988	740	1	https://doi.org/10.3762/bjoc.17.75	https://doi.org/10.3762/bjoc.17.75	NOUN
admet-2988	741	1	[	[	X
admet-2988	741	2	113	113	NUM
admet-2988	741	3	]	]	X
admet-2988	741	4	y.	y.	PROPN
admet-2988	741	5	han	han	PROPN
admet-2988	741	6	,	,	PUNCT
admet-2988	741	7	c.	c.	PROPN
admet-2988	741	8	gao	gao	PROPN
admet-2988	741	9	,	,	PUNCT
admet-2988	741	10	h.	h.	PROPN
admet-2988	741	11	wang	wang	PROPN
admet-2988	741	12	,	,	PUNCT
admet-2988	741	13	j.	j.	PROPN
admet-2988	741	14	sun	sun	PROPN
admet-2988	741	15	,	,	PUNCT
admet-2988	741	16	m.	m.	PROPN
admet-2988	741	17	liang	liang	PROPN
admet-2988	741	18	,	,	PUNCT
admet-2988	741	19	y.	y.	PROPN
admet-2988	741	20	feng	feng	PROPN
admet-2988	741	21	,	,	PUNCT
admet-2988	741	22	q.	q.	PROPN
admet-2988	741	23	liu	liu	PROPN
admet-2988	741	24	,	,	PUNCT
admet-2988	741	25	s.	s.	PROPN
admet-2988	741	26	fu	fu	PROPN
admet-2988	741	27	,	,	PUNCT
admet-2988	741	28	l.	l.	PROPN
admet-2988	741	29	cui	cui	PROPN
admet-2988	741	30	,	,	PUNCT
admet-2988	741	31	c.	c.	PROPN
admet-2988	741	32	gao	gao	PROPN
admet-2988	741	33	,	,	PUNCT
admet-2988	741	34	y.	y.	PROPN
admet-2988	741	35	li	li	PROPN
admet-2988	741	36	,	,	PUNCT
admet-2988	741	37	y.	y.	PROPN
admet-2988	741	38	yang	yang	PROPN
admet-2988	741	39	,	,	PUNCT
admet-2988	741	40	b.	b.	PROPN
admet-2988	741	41	sun	sun	PROPN
admet-2988	741	42	.	.	PUNCT
admet-2988	741	43	macrophage	macrophage	ADJ
admet-2988	741	44	membrane	membrane	NOUN
admet-2988	741	45	-	-	PUNCT
admet-2988	741	46	coated	coat	VERB
admet-2988	741	47	nanocarriers	nanocarrier	NOUN
admet-2988	741	48	co	co	VERB
admet-2988	741	49	-	-	VERB
admet-2988	741	50	modified	modify	VERB
admet-2988	741	51	by	by	ADP
admet-2988	741	52	rvg29	rvg29	PROPN
admet-2988	741	53	and	and	CCONJ
admet-2988	741	54	tpp	tpp	PROPN
admet-2988	741	55	improve	improve	VERB
admet-2988	741	56	brain	brain	NOUN
admet-2988	741	57	neuronal	neuronal	ADJ
admet-2988	741	58	mitochondria	mitochondria	NOUN
admet-2988	741	59	-	-	PUNCT
admet-2988	741	60	targeting	target	VERB
admet-2988	741	61	and	and	CCONJ
admet-2988	741	62	therapeutic	therapeutic	ADJ
admet-2988	741	63	efficacy	efficacy	NOUN
admet-2988	741	64	in	in	ADP
admet-2988	741	65	alzheimer	alzheimer	PROPN
admet-2988	741	66	’s	’s	PART
admet-2988	741	67	disease	disease	NOUN
admet-2988	741	68	mice	mouse	NOUN
admet-2988	741	69	.	.	PUNCT
admet-2988	742	1	bioactive	bioactive	ADJ
admet-2988	742	2	materials	material	NOUN
admet-2988	742	3	6	6	NUM
admet-2988	742	4	(	(	PUNCT
admet-2988	742	5	2021	2021	NUM
admet-2988	742	6	)	)	PUNCT
admet-2988	742	7	529	529	NUM
admet-2988	742	8	-	-	SYM
admet-2988	742	9	542	542	NUM
admet-2988	742	10	.	.	PUNCT
admet-2988	743	1	https://doi.org/10.1016/j.bioactmat.2020.08.017	https://doi.org/10.1016/j.bioactmat.2020.08.017	NUM
admet-2988	743	2	https://doi.org/10.1016/j.ejpb.2018.09.012	https://doi.org/10.1016/j.ejpb.2018.09.012	PROPN
admet-2988	743	3	https://doi.org/10.1016/j.scp.2017.07.002	https://doi.org/10.1016/j.scp.2017.07.002	VERB
admet-2988	743	4	https://doi.org/10.7759/cureus.44302	https://doi.org/10.7759/cureus.44302	NOUN
admet-2988	743	5	https://doi.org/10.2147/ijn.s231479	https://doi.org/10.2147/ijn.s231479	NOUN
admet-2988	743	6	https://doi.org/10.1021/acsami.0c05556	https://doi.org/10.1021/acsami.0c05556	PROPN
admet-2988	743	7	https://doi.org/10.1016/j.ijpharm.2020.120011	https://doi.org/10.1016/j.ijpharm.2020.120011	PROPN
admet-2988	743	8	https://doi.org/10.1021/acschemneuro.8b00292	https://doi.org/10.1021/acschemneuro.8b00292	ADP
admet-2988	743	9	https://doi.org/10.1126/sciadv.abb4429	https://doi.org/10.1126/sciadv.abb4429	PROPN
admet-2988	743	10	https://doi.org/10.1016/j.foodchem.2023.135682	https://doi.org/10.1016/j.foodchem.2023.135682	ADJ
admet-2988	743	11	https://doi.org/10.1016/j.colsurfb.2016.05.037	https://doi.org/10.1016/j.colsurfb.2016.05.037	NOUN
admet-2988	743	12	https://doi.org/10.1016/j.ejpb.2020.08.015	https://doi.org/10.1016/j.ejpb.2020.08.015	PRON
admet-2988	743	13	https://doi.org/10.1016/j.jtice.2017.04.026	https://doi.org/10.1016/j.jtice.2017.04.026	PROPN
admet-2988	743	14	https://doi.org/10.3762/bjoc.17.75	https://doi.org/10.3762/bjoc.17.75	ADJ
admet-2988	743	15	https://doi.org/10.1016/j.bioactmat.2020.08.017	https://doi.org/10.1016/j.bioactmat.2020.08.017	NUM
admet-2988	743	16	admet	admet	X
admet-2988	743	17	&	&	CCONJ
admet-2988	743	18	dmpk	dmpk	PROPN
admet-2988	743	19	13(5	13(5	NOUN
admet-2988	743	20	)	)	PUNCT
admet-2988	743	21	(	(	PUNCT
admet-2988	743	22	2025	2025	NUM
admet-2988	743	23	)	)	PUNCT
admet-2988	743	24	2988	2988	NUM
admet-2988	743	25	advancing	advance	VERB
admet-2988	743	26	through	through	ADP
admet-2988	743	27	the	the	DET
admet-2988	743	28	blood	blood	NOUN
admet-2988	743	29	-	-	PUNCT
admet-2988	743	30	brain	brain	NOUN
admet-2988	743	31	barrier	barrier	NOUN
admet-2988	743	32	doi	doi	NOUN
admet-2988	743	33	:	:	PUNCT
admet-2988	743	34	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	743	35	23	23	NUM
admet-2988	744	1	[	[	SYM
admet-2988	744	2	114	114	NUM
admet-2988	744	3	]	]	PUNCT
admet-2988	744	4	v.	v.	PROPN
admet-2988	744	5	apostolopoulos	apostolopoulos	PROPN
admet-2988	744	6	,	,	PUNCT
admet-2988	744	7	j.	j.	PROPN
admet-2988	744	8	bojarska	bojarska	PROPN
admet-2988	744	9	,	,	PUNCT
admet-2988	744	10	t.t	t.t	PROPN
admet-2988	744	11	.	.	PROPN
admet-2988	744	12	chai	chai	PROPN
admet-2988	744	13	,	,	PUNCT
admet-2988	744	14	s.	s.	PROPN
admet-2988	744	15	elnagdy	elnagdy	PROPN
admet-2988	744	16	,	,	PUNCT
admet-2988	744	17	k.	k.	PROPN
admet-2988	744	18	kaczmarek	kaczmarek	PROPN
admet-2988	744	19	,	,	PUNCT
admet-2988	744	20	j.	j.	PROPN
admet-2988	744	21	matsoukas	matsoukas	PROPN
admet-2988	744	22	,	,	PUNCT
admet-2988	744	23	r.	r.	PROPN
admet-2988	744	24	new	new	PROPN
admet-2988	744	25	,	,	PUNCT
admet-2988	744	26	k.	k.	PROPN
admet-2988	744	27	parang	parang	PROPN
admet-2988	744	28	,	,	PUNCT
admet-2988	744	29	o.p	o.p	PROPN
admet-2988	744	30	.	.	PROPN
admet-2988	744	31	lopez	lopez	PROPN
admet-2988	744	32	,	,	PUNCT
admet-2988	744	33	h.	h.	PROPN
admet-2988	744	34	parhiz	parhiz	PROPN
admet-2988	744	35	,	,	PUNCT
admet-2988	744	36	c.o	c.o	PROPN
admet-2988	744	37	.	.	PROPN
admet-2988	744	38	perera	perera	PROPN
admet-2988	744	39	,	,	PUNCT
admet-2988	744	40	m.	m.	NOUN
admet-2988	744	41	pickholz	pickholz	PROPN
admet-2988	744	42	,	,	PUNCT
admet-2988	744	43	m.	m.	NOUN
admet-2988	744	44	remko	remko	NOUN
admet-2988	744	45	,	,	PUNCT
admet-2988	744	46	m.	m.	NOUN
admet-2988	744	47	saviano	saviano	PROPN
admet-2988	744	48	,	,	PUNCT
admet-2988	744	49	m.	m.	NOUN
admet-2988	744	50	skwarczynski	skwarczynski	PROPN
admet-2988	744	51	,	,	PUNCT
admet-2988	744	52	y.	y.	PROPN
admet-2988	744	53	tang	tang	PROPN
admet-2988	744	54	,	,	PUNCT
admet-2988	744	55	w.m	w.m	PROPN
admet-2988	744	56	.	.	PROPN
admet-2988	744	57	wolf	wolf	PROPN
admet-2988	744	58	,	,	PUNCT
admet-2988	744	59	t.	t.	PROPN
admet-2988	744	60	yoshiya	yoshiya	PROPN
admet-2988	744	61	,	,	PUNCT
admet-2988	744	62	j.	j.	PROPN
admet-2988	744	63	zabrocki	zabrocki	PROPN
admet-2988	744	64	,	,	PUNCT
admet-2988	744	65	p.	p.	NOUN
admet-2988	744	66	zielenkiewicz	zielenkiewicz	NOUN
admet-2988	744	67	,	,	PUNCT
admet-2988	744	68	m.	m.	NOUN
admet-2988	744	69	alkhazindar	alkhazindar	PROPN
admet-2988	744	70	,	,	PUNCT
admet-2988	744	71	v.	v.	PROPN
admet-2988	744	72	barriga	barriga	PROPN
admet-2988	744	73	,	,	PUNCT
admet-2988	744	74	k.	k.	PROPN
admet-2988	744	75	kelaidonis	kelaidonis	PROPN
admet-2988	744	76	,	,	PUNCT
admet-2988	744	77	e.m	e.m	PROPN
admet-2988	744	78	.	.	PROPN
admet-2988	744	79	sarasia	sarasia	PROPN
admet-2988	744	80	,	,	PUNCT
admet-2988	744	81	i.	i.	PROPN
admet-2988	744	82	toth	toth	PROPN
admet-2988	744	83	.	.	PUNCT
admet-2988	745	1	a	a	DET
admet-2988	745	2	global	global	ADJ
admet-2988	745	3	review	review	NOUN
admet-2988	745	4	on	on	ADP
admet-2988	745	5	short	short	ADJ
admet-2988	745	6	peptides	peptide	NOUN
admet-2988	745	7	:	:	PUNCT
admet-2988	745	8	frontiers	frontier	NOUN
admet-2988	745	9	and	and	CCONJ
admet-2988	745	10	perspectives	perspective	NOUN
admet-2988	745	11	.	.	PUNCT
admet-2988	746	1	molecules	molecule	NOUN
admet-2988	746	2	26	26	NUM
admet-2988	746	3	(	(	PUNCT
admet-2988	746	4	2021	2021	NUM
admet-2988	746	5	)	)	PUNCT
admet-2988	746	6	430	430	NUM
admet-2988	746	7	.	.	PUNCT
admet-2988	747	1	https://doi.org/10.3390/molecules26020430	https://doi.org/10.3390/molecules26020430	PROPN
admet-2988	747	2	[	[	X
admet-2988	747	3	115	115	NUM
admet-2988	747	4	]	]	PUNCT
admet-2988	747	5	a.	a.	NOUN
admet-2988	747	6	accardo	accardo	PROPN
admet-2988	747	7	,	,	PUNCT
admet-2988	747	8	d.	d.	PROPN
admet-2988	747	9	tesauro	tesauro	PROPN
admet-2988	747	10	,	,	PUNCT
admet-2988	747	11	g.	g.	PROPN
admet-2988	747	12	morelli	morelli	PROPN
admet-2988	747	13	.	.	PUNCT
admet-2988	748	1	peptide	peptide	NOUN
admet-2988	748	2	-	-	PUNCT
admet-2988	748	3	based	base	VERB
admet-2988	748	4	targeting	targeting	NOUN
admet-2988	748	5	strategies	strategy	NOUN
admet-2988	748	6	for	for	ADP
admet-2988	748	7	simultaneous	simultaneous	ADJ
admet-2988	748	8	imaging	imaging	NOUN
admet-2988	748	9	and	and	CCONJ
admet-2988	748	10	therapy	therapy	NOUN
admet-2988	748	11	with	with	ADP
admet-2988	748	12	nanovectors	nanovector	NOUN
admet-2988	748	13	.	.	PUNCT
admet-2988	749	1	polymer	polymer	NOUN
admet-2988	749	2	journal	journal	NOUN
admet-2988	749	3	45	45	NUM
admet-2988	749	4	(	(	PUNCT
admet-2988	749	5	2013	2013	NUM
admet-2988	749	6	)	)	PUNCT
admet-2988	749	7	481	481	NUM
admet-2988	749	8	-	-	SYM
admet-2988	749	9	493	493	NUM
admet-2988	749	10	.	.	PUNCT
admet-2988	750	1	https://doi.org/10.1038/pj.2012.215	https://doi.org/10.1038/pj.2012.215	X
admet-2988	751	1	[	[	X
admet-2988	751	2	116	116	X
admet-2988	751	3	]	]	PUNCT
admet-2988	751	4	s.	s.	PROPN
admet-2988	751	5	andrade	andrade	PROPN
admet-2988	751	6	,	,	PUNCT
admet-2988	751	7	j.a	j.a	PROPN
admet-2988	751	8	.	.	PROPN
admet-2988	751	9	loureiro	loureiro	PROPN
admet-2988	751	10	,	,	PUNCT
admet-2988	751	11	m.j	m.j	PROPN
admet-2988	751	12	.	.	PROPN
admet-2988	751	13	ramalho	ramalho	PROPN
admet-2988	751	14	,	,	PUNCT
admet-2988	751	15	s.	s.	PROPN
admet-2988	751	16	habib	habib	PROPN
admet-2988	751	17	,	,	PUNCT
admet-2988	751	18	m.	m.	NOUN
admet-2988	751	19	singh	singh	PROPN
admet-2988	751	20	.	.	PUNCT
admet-2988	752	1	angiopep-2	angiopep-2	NOUN
admet-2988	752	2	-	-	PUNCT
admet-2988	752	3	modified	modify	VERB
admet-2988	752	4	nanoparticles	nanoparticle	NOUN
admet-2988	752	5	for	for	ADP
admet-2988	752	6	brain	brain	NOUN
admet-2988	752	7	-	-	PUNCT
admet-2988	752	8	directed	direct	VERB
admet-2988	752	9	delivery	delivery	NOUN
admet-2988	752	10	of	of	ADP
admet-2988	752	11	therapeutics	therapeutic	NOUN
admet-2988	752	12	:	:	PUNCT
admet-2988	752	13	a	a	DET
admet-2988	752	14	review	review	NOUN
admet-2988	752	15	.	.	PUNCT
admet-2988	753	1	polymers	polymer	NOUN
admet-2988	753	2	14	14	NUM
admet-2988	753	3	(	(	PUNCT
admet-2988	753	4	2022	2022	NUM
admet-2988	753	5	)	)	PUNCT
admet-2988	753	6	712	712	NUM
admet-2988	753	7	.	.	PUNCT
admet-2988	754	1	https://doi.org/10.3390/polym14040712	https://doi.org/10.3390/polym14040712	NOUN
admet-2988	754	2	[	[	X
admet-2988	754	3	117	117	NUM
admet-2988	754	4	]	]	X
admet-2988	754	5	c.	c.	PROPN
admet-2988	754	6	díaz	díaz	PROPN
admet-2988	754	7	-	-	PUNCT
admet-2988	754	8	perlas	perlas	PROPN
admet-2988	754	9	,	,	PUNCT
admet-2988	754	10	b.	b.	PROPN
admet-2988	754	11	oller	oller	PROPN
admet-2988	754	12	-	-	PUNCT
admet-2988	754	13	salvia	salvia	PROPN
admet-2988	754	14	,	,	PUNCT
admet-2988	754	15	m.	m.	NOUN
admet-2988	754	16	sánchez	sánchez	PROPN
admet-2988	754	17	-	-	PUNCT
admet-2988	754	18	navarro	navarro	PROPN
admet-2988	754	19	,	,	PUNCT
admet-2988	754	20	m.	m.	NOUN
admet-2988	754	21	teixidó	teixidó	PROPN
admet-2988	754	22	,	,	PUNCT
admet-2988	754	23	e.	e.	PROPN
admet-2988	754	24	giralt	giralt	PROPN
admet-2988	754	25	.	.	PUNCT
admet-2988	755	1	branched	branch	VERB
admet-2988	755	2	bbb	bbb	PROPN
admet-2988	755	3	-	-	PUNCT
admet-2988	755	4	shuttle	shuttle	NOUN
admet-2988	755	5	peptides	peptide	NOUN
admet-2988	755	6	:	:	PUNCT
admet-2988	755	7	chemoselective	chemoselective	ADJ
admet-2988	755	8	modification	modification	NOUN
admet-2988	755	9	of	of	ADP
admet-2988	755	10	proteins	protein	NOUN
admet-2988	755	11	to	to	PART
admet-2988	755	12	enhance	enhance	VERB
admet-2988	755	13	blood	blood	NOUN
admet-2988	755	14	-	-	PUNCT
admet-2988	755	15	brain	brain	NOUN
admet-2988	755	16	barrier	barrier	NOUN
admet-2988	755	17	transport	transport	NOUN
admet-2988	755	18	.	.	PUNCT
admet-2988	756	1	chemical	chemical	ADJ
admet-2988	756	2	science	science	NOUN
admet-2988	756	3	9	9	NUM
admet-2988	756	4	(	(	PUNCT
admet-2988	756	5	2018	2018	NUM
admet-2988	756	6	)	)	PUNCT
admet-2988	756	7	8409	8409	NUM
admet-2988	756	8	-	-	SYM
admet-2988	756	9	8415	8415	NUM
admet-2988	756	10	.	.	PUNCT
admet-2988	757	1	https://doi.org/10.1039/c8sc02415d	https://doi.org/10.1039/c8sc02415d	PROPN
admet-2988	758	1	[	[	X
admet-2988	758	2	118	118	NUM
admet-2988	758	3	]	]	PUNCT
admet-2988	758	4	b.	b.	PROPN
admet-2988	758	5	oller	oller	PROPN
admet-2988	758	6	-	-	PUNCT
admet-2988	758	7	salvia	salvia	PROPN
admet-2988	758	8	,	,	PUNCT
admet-2988	758	9	m.	m.	NOUN
admet-2988	758	10	sánchez	sánchez	PROPN
admet-2988	758	11	-	-	PUNCT
admet-2988	758	12	navarro	navarro	PROPN
admet-2988	758	13	,	,	PUNCT
admet-2988	758	14	e.	e.	PROPN
admet-2988	758	15	giralt	giralt	PROPN
admet-2988	758	16	,	,	PUNCT
admet-2988	758	17	m.	m.	NOUN
admet-2988	758	18	teixidó	teixidó	NOUN
admet-2988	758	19	.	.	PUNCT
admet-2988	759	1	blood	blood	NOUN
admet-2988	759	2	-	-	PUNCT
admet-2988	759	3	brain	brain	NOUN
admet-2988	759	4	barrier	barrier	NOUN
admet-2988	759	5	shuttle	shuttle	NOUN
admet-2988	759	6	peptides	peptide	NOUN
admet-2988	759	7	:	:	PUNCT
admet-2988	759	8	an	an	DET
admet-2988	759	9	emerging	emerge	VERB
admet-2988	759	10	paradigm	paradigm	NOUN
admet-2988	759	11	for	for	ADP
admet-2988	759	12	brain	brain	NOUN
admet-2988	759	13	delivery	delivery	NOUN
admet-2988	759	14	.	.	PUNCT
admet-2988	760	1	chemical	chemical	ADJ
admet-2988	760	2	society	society	PROPN
admet-2988	760	3	reviews	review	VERB
admet-2988	760	4	45	45	NUM
admet-2988	760	5	(	(	PUNCT
admet-2988	760	6	2016	2016	NUM
admet-2988	760	7	)	)	PUNCT
admet-2988	760	8	4690	4690	NUM
admet-2988	760	9	-	-	SYM
admet-2988	760	10	4707	4707	NUM
admet-2988	760	11	.	.	PUNCT
admet-2988	761	1	https://doi.org/10.1039/c6cs00076b	https://doi.org/10.1039/c6cs00076b	PROPN
admet-2988	761	2	[	[	X
admet-2988	761	3	119	119	NUM
admet-2988	761	4	]	]	X
admet-2988	761	5	r.	r.	PROPN
admet-2988	761	6	prades	prades	PROPN
admet-2988	761	7	,	,	PUNCT
admet-2988	761	8	b.	b.	PROPN
admet-2988	761	9	oller	oller	PROPN
admet-2988	761	10	-	-	PUNCT
admet-2988	761	11	salvia	salvia	PROPN
admet-2988	761	12	,	,	PUNCT
admet-2988	761	13	s.m	s.m	PROPN
admet-2988	761	14	.	.	PROPN
admet-2988	761	15	schwarzmaier	schwarzmaier	PROPN
admet-2988	761	16	,	,	PUNCT
admet-2988	761	17	j.	j.	PROPN
admet-2988	761	18	selva	selva	PROPN
admet-2988	761	19	,	,	PUNCT
admet-2988	761	20	m.	m.	NOUN
admet-2988	761	21	moros	moros	PROPN
admet-2988	761	22	,	,	PUNCT
admet-2988	761	23	m.	m.	PROPN
admet-2988	761	24	balbi	balbi	PROPN
admet-2988	761	25	,	,	PUNCT
admet-2988	761	26	v.	v.	ADP
admet-2988	761	27	grazú	grazú	NOUN
admet-2988	761	28	,	,	PUNCT
admet-2988	761	29	j.m	j.m	PROPN
admet-2988	761	30	.	.	PROPN
admet-2988	761	31	de	de	X
admet-2988	761	32	la	la	X
admet-2988	761	33	fuente	fuente	PROPN
admet-2988	761	34	,	,	PUNCT
admet-2988	761	35	g.	g.	PROPN
admet-2988	761	36	egea	egea	PROPN
admet-2988	761	37	,	,	PUNCT
admet-2988	761	38	n.	n.	PROPN
admet-2988	761	39	plesnila	plesnila	PROPN
admet-2988	761	40	,	,	PUNCT
admet-2988	761	41	m.	m.	NOUN
admet-2988	761	42	teixidõ	teixidõ	PROPN
admet-2988	761	43	,	,	PUNCT
admet-2988	761	44	e.	e.	PROPN
admet-2988	761	45	giralt	giralt	PROPN
admet-2988	761	46	.	.	PUNCT
admet-2988	762	1	applying	apply	VERB
admet-2988	762	2	the	the	DET
admet-2988	762	3	retro	retro	VERB
admet-2988	762	4	-	-	PUNCT
admet-2988	762	5	enantio	enantio	ADJ
admet-2988	762	6	approach	approach	NOUN
admet-2988	762	7	to	to	PART
admet-2988	762	8	obtain	obtain	VERB
admet-2988	762	9	a	a	DET
admet-2988	762	10	peptide	peptide	NOUN
admet-2988	762	11	capable	capable	ADJ
admet-2988	762	12	of	of	ADP
admet-2988	762	13	overcoming	overcome	VERB
admet-2988	762	14	the	the	DET
admet-2988	762	15	blood	blood	NOUN
admet-2988	762	16	-	-	PUNCT
admet-2988	762	17	brain	brain	NOUN
admet-2988	762	18	barrier	barrier	NOUN
admet-2988	762	19	.	.	PUNCT
admet-2988	763	1	angewandte	angewandte	PROPN
admet-2988	763	2	chemie	chemie	PROPN
admet-2988	763	3	international	international	PROPN
admet-2988	763	4	edition	edition	PROPN
admet-2988	763	5	54	54	NUM
admet-2988	763	6	(	(	PUNCT
admet-2988	763	7	2015	2015	NUM
admet-2988	763	8	)	)	PUNCT
admet-2988	763	9	3967	3967	NUM
admet-2988	763	10	-	-	SYM
admet-2988	763	11	3972	3972	NUM
admet-2988	763	12	.	.	PUNCT
admet-2988	763	13	https://doi.org/10.1002/anie.201411408	https://doi.org/10.1002/anie.201411408	PUNCT
admet-2988	764	1	[	[	X
admet-2988	764	2	120	120	NUM
admet-2988	764	3	]	]	X
admet-2988	764	4	j.h	j.h	PROPN
admet-2988	764	5	.	.	PROPN
admet-2988	764	6	lee	lee	PROPN
admet-2988	764	7	,	,	PUNCT
admet-2988	764	8	j.a	j.a	PROPN
admet-2988	764	9	.	.	PROPN
admet-2988	764	10	engler	engler	PROPN
admet-2988	764	11	,	,	PUNCT
admet-2988	764	12	j.f	j.f	PROPN
admet-2988	764	13	.	.	PROPN
admet-2988	764	14	collawn	collawn	PROPN
admet-2988	764	15	,	,	PUNCT
admet-2988	764	16	b.a	b.a	PROPN
admet-2988	764	17	.	.	PROPN
admet-2988	764	18	moore	moore	PROPN
admet-2988	764	19	.	.	PUNCT
admet-2988	765	1	receptor	receptor	NOUN
admet-2988	765	2	mediated	mediate	VERB
admet-2988	765	3	uptake	uptake	NOUN
admet-2988	765	4	of	of	ADP
admet-2988	765	5	peptides	peptide	NOUN
admet-2988	765	6	that	that	PRON
admet-2988	765	7	bind	bind	VERB
admet-2988	765	8	the	the	DET
admet-2988	765	9	human	human	ADJ
admet-2988	765	10	transferrin	transferrin	NOUN
admet-2988	765	11	receptor	receptor	NOUN
admet-2988	765	12	.	.	PUNCT
admet-2988	766	1	european	european	ADJ
admet-2988	766	2	journal	journal	PROPN
admet-2988	766	3	of	of	ADP
admet-2988	766	4	biochemistry	biochemistry	NOUN
admet-2988	766	5	268	268	NUM
admet-2988	766	6	(	(	PUNCT
admet-2988	766	7	2001	2001	NUM
admet-2988	766	8	)	)	PUNCT
admet-2988	766	9	2004	2004	NUM
admet-2988	766	10	-	-	SYM
admet-2988	766	11	2012	2012	NUM
admet-2988	766	12	.	.	PUNCT
admet-2988	767	1	https://doi.org/10.1046/j.1432-1327.2001.02073.x	https://doi.org/10.1046/j.1432-1327.2001.02073.x	PRON
admet-2988	768	1	[	[	X
admet-2988	768	2	121	121	NUM
admet-2988	768	3	]	]	PUNCT
admet-2988	768	4	a.	a.	NOUN
admet-2988	768	5	faissner	faissner	NOUN
admet-2988	768	6	.	.	PUNCT
admet-2988	769	1	low	low	ADJ
admet-2988	769	2	-	-	PUNCT
admet-2988	769	3	density	density	NOUN
admet-2988	769	4	lipoprotein	lipoprotein	ADJ
admet-2988	769	5	receptor	receptor	NOUN
admet-2988	769	6	-	-	PUNCT
admet-2988	769	7	related	relate	VERB
admet-2988	769	8	protein-1	protein-1	PROPN
admet-2988	769	9	(	(	PUNCT
admet-2988	769	10	lrp1	lrp1	PROPN
admet-2988	769	11	)	)	PUNCT
admet-2988	769	12	in	in	ADP
admet-2988	769	13	the	the	DET
admet-2988	769	14	glial	glial	ADJ
admet-2988	769	15	lineage	lineage	NOUN
admet-2988	769	16	modulates	modulate	VERB
admet-2988	769	17	neuronal	neuronal	ADJ
admet-2988	769	18	excitability	excitability	NOUN
admet-2988	769	19	.	.	PUNCT
admet-2988	770	1	frontiers	frontier	NOUN
admet-2988	770	2	in	in	ADP
admet-2988	770	3	network	network	NOUN
admet-2988	770	4	physiology	physiology	NOUN
admet-2988	770	5	3	3	NUM
admet-2988	770	6	(	(	PUNCT
admet-2988	770	7	2023	2023	NUM
admet-2988	770	8	)	)	PUNCT
admet-2988	770	9	1190240	1190240	NUM
admet-2988	770	10	.	.	PUNCT
admet-2988	771	1	https://doi.org/10.3389/fnetp.2023.1190240	https://doi.org/10.3389/fnetp.2023.1190240	PROPN
admet-2988	772	1	[	[	X
admet-2988	772	2	122	122	NUM
admet-2988	772	3	]	]	PUNCT
admet-2988	772	4	j.	j.	PROPN
admet-2988	772	5	chen	chen	PROPN
admet-2988	772	6	,	,	PUNCT
admet-2988	772	7	y.	y.	PROPN
admet-2988	772	8	su	su	PROPN
admet-2988	772	9	,	,	PUNCT
admet-2988	772	10	s.	s.	PROPN
admet-2988	772	11	pi	pi	PROPN
admet-2988	772	12	,	,	PUNCT
admet-2988	772	13	b.	b.	PROPN
admet-2988	772	14	hu	hu	PROPN
admet-2988	772	15	,	,	PUNCT
admet-2988	772	16	l.	l.	PROPN
admet-2988	772	17	mao	mao	PROPN
admet-2988	772	18	.	.	PUNCT
admet-2988	773	1	the	the	DET
admet-2988	773	2	dual	dual	ADJ
admet-2988	773	3	role	role	NOUN
admet-2988	773	4	of	of	ADP
admet-2988	773	5	low	low	ADJ
admet-2988	773	6	-	-	PUNCT
admet-2988	773	7	density	density	NOUN
admet-2988	773	8	lipoprotein	lipoprotein	ADJ
admet-2988	773	9	receptor	receptor	NOUN
admet-2988	773	10	-	-	PUNCT
admet-2988	773	11	related	relate	VERB
admet-2988	773	12	protein	protein	NOUN
admet-2988	773	13	1	1	NUM
admet-2988	773	14	in	in	ADP
admet-2988	773	15	atherosclerosis	atherosclerosis	NOUN
admet-2988	773	16	.	.	PUNCT
admet-2988	774	1	frontiers	frontier	NOUN
admet-2988	774	2	in	in	ADP
admet-2988	774	3	cardiovascular	cardiovascular	ADJ
admet-2988	774	4	medicine	medicine	NOUN
admet-2988	774	5	8	8	NUM
admet-2988	774	6	(	(	PUNCT
admet-2988	774	7	2021	2021	NUM
admet-2988	774	8	)	)	PUNCT
admet-2988	774	9	682389	682389	NUM
admet-2988	774	10	.	.	PUNCT
admet-2988	775	1	https://doi.org/10.3389/fcvm.2021.682389	https://doi.org/10.3389/fcvm.2021.682389	PROPN
admet-2988	776	1	[	[	X
admet-2988	776	2	123	123	NUM
admet-2988	776	3	]	]	PUNCT
admet-2988	776	4	r.	r.	PROPN
admet-2988	776	5	huey	huey	PROPN
admet-2988	776	6	,	,	PUNCT
admet-2988	776	7	s.	s.	PROPN
admet-2988	776	8	hawthorne	hawthorne	PROPN
admet-2988	776	9	,	,	PUNCT
admet-2988	776	10	p.	p.	PROPN
admet-2988	776	11	mccarron	mccarron	PROPN
admet-2988	776	12	.	.	PUNCT
admet-2988	777	1	the	the	DET
admet-2988	777	2	potential	potential	ADJ
admet-2988	777	3	use	use	NOUN
admet-2988	777	4	of	of	ADP
admet-2988	777	5	rabies	rabie	NOUN
admet-2988	777	6	virus	virus	NOUN
admet-2988	777	7	glycoprotein	glycoprotein	NOUN
admet-2988	777	8	-	-	PUNCT
admet-2988	777	9	derived	derive	VERB
admet-2988	777	10	peptides	peptide	NOUN
admet-2988	777	11	to	to	PART
admet-2988	777	12	facilitate	facilitate	VERB
admet-2988	777	13	drug	drug	NOUN
admet-2988	777	14	delivery	delivery	NOUN
admet-2988	777	15	into	into	ADP
admet-2988	777	16	the	the	DET
admet-2988	777	17	central	central	ADJ
admet-2988	777	18	nervous	nervous	ADJ
admet-2988	777	19	system	system	NOUN
admet-2988	777	20	:	:	PUNCT
admet-2988	777	21	a	a	DET
admet-2988	777	22	mini	mini	ADJ
admet-2988	777	23	review	review	NOUN
admet-2988	777	24	.	.	PUNCT
admet-2988	778	1	journal	journal	PROPN
admet-2988	778	2	of	of	ADP
admet-2988	778	3	drug	drug	NOUN
admet-2988	778	4	targeting	target	VERB
admet-2988	778	5	25	25	NUM
admet-2988	778	6	(	(	PUNCT
admet-2988	778	7	2017	2017	NUM
admet-2988	778	8	)	)	PUNCT
admet-2988	778	9	379	379	NUM
admet-2988	778	10	-	-	SYM
admet-2988	778	11	385	385	NUM
admet-2988	778	12	.	.	PUNCT
admet-2988	779	1	https://doi.org/10.1080/1061186x.2016.1223676	https://doi.org/10.1080/1061186x.2016.1223676	PRON
admet-2988	780	1	[	[	X
admet-2988	780	2	124	124	NUM
admet-2988	780	3	]	]	PUNCT
admet-2988	780	4	b.	b.	PROPN
admet-2988	780	5	oller	oller	PROPN
admet-2988	780	6	-	-	PUNCT
admet-2988	780	7	salvia	salvia	PROPN
admet-2988	780	8	,	,	PUNCT
admet-2988	780	9	m.	m.	NOUN
admet-2988	780	10	sánchez	sánchez	PROPN
admet-2988	780	11	-	-	PUNCT
admet-2988	780	12	navarro	navarro	PROPN
admet-2988	780	13	,	,	PUNCT
admet-2988	780	14	s.	s.	PROPN
admet-2988	780	15	ciudad	ciudad	PROPN
admet-2988	780	16	,	,	PUNCT
admet-2988	780	17	m.	m.	NOUN
admet-2988	780	18	guiu	guiu	NOUN
admet-2988	780	19	,	,	PUNCT
admet-2988	780	20	p.	p.	PROPN
admet-2988	780	21	arranz	arranz	PROPN
admet-2988	780	22	-	-	PUNCT
admet-2988	780	23	gibert	gibert	NOUN
admet-2988	780	24	,	,	PUNCT
admet-2988	780	25	c.	c.	PROPN
admet-2988	780	26	garcia	garcia	PROPN
admet-2988	780	27	,	,	PUNCT
admet-2988	780	28	r.r	r.r	PROPN
admet-2988	780	29	.	.	PROPN
admet-2988	780	30	gomis	gomis	PROPN
admet-2988	780	31	,	,	PUNCT
admet-2988	780	32	r.	r.	PROPN
admet-2988	780	33	cecchelli	cecchelli	PROPN
admet-2988	780	34	,	,	PUNCT
admet-2988	780	35	j.	j.	PROPN
admet-2988	780	36	garcía	garcía	PROPN
admet-2988	780	37	,	,	PUNCT
admet-2988	780	38	e.	e.	PROPN
admet-2988	780	39	giralt	giralt	PROPN
admet-2988	780	40	,	,	PUNCT
admet-2988	780	41	m.	m.	NOUN
admet-2988	780	42	teixidõ	teixidõ	NOUN
admet-2988	780	43	.	.	PUNCT
admet-2988	781	1	miniap-4	miniap-4	NUM
admet-2988	781	2	:	:	PUNCT
admet-2988	781	3	a	a	DET
admet-2988	781	4	venom	venom	ADV
admet-2988	781	5	-	-	PUNCT
admet-2988	781	6	inspired	inspire	VERB
admet-2988	781	7	peptidomimetic	peptidomimetic	NOUN
admet-2988	781	8	for	for	ADP
admet-2988	781	9	brain	brain	NOUN
admet-2988	781	10	delivery	delivery	NOUN
admet-2988	781	11	.	.	PUNCT
admet-2988	782	1	angewandte	angewandte	PROPN
admet-2988	782	2	chemie	chemie	PROPN
admet-2988	782	3	(	(	PUNCT
admet-2988	782	4	international	international	ADJ
admet-2988	782	5	ed	ed	NOUN
admet-2988	782	6	.	.	PUNCT
admet-2988	783	1	in	in	ADP
admet-2988	783	2	english	english	PROPN
admet-2988	783	3	)	)	PUNCT
admet-2988	783	4	55	55	NUM
admet-2988	783	5	(	(	PUNCT
admet-2988	783	6	2016	2016	NUM
admet-2988	783	7	)	)	PUNCT
admet-2988	783	8	572	572	NUM
admet-2988	783	9	-	-	SYM
admet-2988	783	10	575	575	NUM
admet-2988	783	11	.	.	PUNCT
admet-2988	783	12	https://doi.org/10.1002/anie.201508445	https://doi.org/10.1002/anie.201508445	NOUN
admet-2988	784	1	[	[	X
admet-2988	784	2	125	125	NUM
admet-2988	784	3	]	]	X
admet-2988	784	4	n.j	n.j	PROPN
admet-2988	784	5	.	.	PROPN
admet-2988	784	6	abbott	abbott	PROPN
admet-2988	784	7	.	.	PUNCT
admet-2988	784	8	blood	blood	NOUN
admet-2988	784	9	-	-	PUNCT
admet-2988	784	10	brain	brain	NOUN
admet-2988	784	11	barrier	barrier	NOUN
admet-2988	784	12	structure	structure	NOUN
admet-2988	784	13	and	and	CCONJ
admet-2988	784	14	function	function	NOUN
admet-2988	784	15	and	and	CCONJ
admet-2988	784	16	the	the	DET
admet-2988	784	17	challenges	challenge	NOUN
admet-2988	784	18	for	for	ADP
admet-2988	784	19	cns	cns	NOUN
admet-2988	784	20	drug	drug	NOUN
admet-2988	784	21	delivery	delivery	NOUN
admet-2988	784	22	.	.	PUNCT
admet-2988	785	1	journal	journal	NOUN
admet-2988	785	2	of	of	ADP
admet-2988	785	3	inherited	inherit	VERB
admet-2988	785	4	metabolic	metabolic	NOUN
admet-2988	785	5	disease	disease	NOUN
admet-2988	785	6	36	36	NUM
admet-2988	785	7	(	(	PUNCT
admet-2988	785	8	2013	2013	NUM
admet-2988	785	9	)	)	PUNCT
admet-2988	785	10	437	437	NUM
admet-2988	785	11	-	-	SYM
admet-2988	785	12	449	449	NUM
admet-2988	785	13	.	.	PUNCT
admet-2988	786	1	https://doi.org/10.1007/s10545-0139608-0	https://doi.org/10.1007/s10545-0139608-0	NOUN
admet-2988	786	2	[	[	X
admet-2988	786	3	126	126	NUM
admet-2988	786	4	]	]	X
admet-2988	786	5	y.	y.	PROPN
admet-2988	786	6	morofuji	morofuji	PROPN
admet-2988	786	7	,	,	PUNCT
admet-2988	786	8	s.	s.	PROPN
admet-2988	786	9	nakagawa	nakagawa	PROPN
admet-2988	786	10	.	.	PUNCT
admet-2988	787	1	drug	drug	NOUN
admet-2988	787	2	development	development	NOUN
admet-2988	787	3	for	for	ADP
admet-2988	787	4	central	central	ADJ
admet-2988	787	5	nervous	nervous	ADJ
admet-2988	787	6	system	system	NOUN
admet-2988	787	7	diseases	disease	NOUN
admet-2988	787	8	using	use	VERB
admet-2988	787	9	in	in	ADP
admet-2988	787	10	vitro	vitro	X
admet-2988	787	11	blood	blood	NOUN
admet-2988	787	12	-	-	PUNCT
admet-2988	787	13	brain	brain	NOUN
admet-2988	787	14	barrier	barrier	NOUN
admet-2988	787	15	models	model	NOUN
admet-2988	787	16	and	and	CCONJ
admet-2988	787	17	drug	drug	NOUN
admet-2988	787	18	repositioning	repositioning	NOUN
admet-2988	787	19	.	.	PUNCT
admet-2988	788	1	current	current	ADJ
admet-2988	788	2	pharmaceutical	pharmaceutical	ADJ
admet-2988	788	3	design	design	NOUN
admet-2988	788	4	26	26	NUM
admet-2988	788	5	(	(	PUNCT
admet-2988	788	6	2020	2020	NUM
admet-2988	788	7	)	)	PUNCT
admet-2988	788	8	14661485	14661485	NUM
admet-2988	788	9	.	.	PUNCT
admet-2988	789	1	https://doi.org/10.2174/1381612826666200224112534	https://doi.org/10.2174/1381612826666200224112534	NOUN
admet-2988	790	1	[	[	X
admet-2988	790	2	127	127	NUM
admet-2988	790	3	]	]	X
admet-2988	790	4	a.s	a.s	PROPN
admet-2988	790	5	.	.	PROPN
admet-2988	790	6	hanafy	hanafy	PROPN
admet-2988	790	7	,	,	PUNCT
admet-2988	790	8	d.	d.	PROPN
admet-2988	790	9	dietrich	dietrich	PROPN
admet-2988	790	10	,	,	PUNCT
admet-2988	790	11	g.	g.	PROPN
admet-2988	790	12	fricker	fricker	PROPN
admet-2988	790	13	,	,	PUNCT
admet-2988	790	14	a.	a.	NOUN
admet-2988	790	15	lamprecht	lamprecht	PROPN
admet-2988	790	16	.	.	PUNCT
admet-2988	791	1	blood	blood	NOUN
admet-2988	791	2	-	-	PUNCT
admet-2988	791	3	brain	brain	NOUN
admet-2988	791	4	barrier	barrier	NOUN
admet-2988	791	5	models	model	NOUN
admet-2988	791	6	:	:	PUNCT
admet-2988	791	7	rationale	rationale	NOUN
admet-2988	791	8	for	for	ADP
admet-2988	791	9	selection	selection	NOUN
admet-2988	791	10	.	.	PUNCT
admet-2988	792	1	advanced	advanced	ADJ
admet-2988	792	2	drug	drug	NOUN
admet-2988	792	3	delivery	delivery	NOUN
admet-2988	792	4	reviews	review	VERB
admet-2988	792	5	176	176	NUM
admet-2988	792	6	(	(	PUNCT
admet-2988	792	7	2021	2021	NUM
admet-2988	792	8	)	)	PUNCT
admet-2988	792	9	113859	113859	NUM
admet-2988	792	10	.	.	PUNCT
admet-2988	793	1	https://doi.org/10.1016/j.addr.2021.113859	https://doi.org/10.1016/j.addr.2021.113859	NOUN
admet-2988	794	1	[	[	X
admet-2988	794	2	128	128	NUM
admet-2988	794	3	]	]	X
admet-2988	794	4	e.	e.	PROPN
admet-2988	794	5	jagtiani	jagtiani	PROPN
admet-2988	794	6	,	,	PUNCT
admet-2988	794	7	m.	m.	NOUN
admet-2988	794	8	yeolekar	yeolekar	PROPN
admet-2988	794	9	,	,	PUNCT
admet-2988	794	10	s.	s.	PROPN
admet-2988	794	11	naik	naik	PROPN
admet-2988	794	12	,	,	PUNCT
admet-2988	794	13	v.	v.	PROPN
admet-2988	794	14	patravale	patravale	PROPN
admet-2988	794	15	.	.	PUNCT
admet-2988	795	1	in	in	ADP
admet-2988	795	2	vitro	vitro	X
admet-2988	795	3	blood	blood	NOUN
admet-2988	795	4	brain	brain	NOUN
admet-2988	795	5	barrier	barrier	NOUN
admet-2988	795	6	models	model	NOUN
admet-2988	795	7	:	:	PUNCT
admet-2988	795	8	an	an	DET
admet-2988	795	9	overview	overview	NOUN
admet-2988	795	10	.	.	PUNCT
admet-2988	796	1	journal	journal	NOUN
admet-2988	796	2	of	of	ADP
admet-2988	796	3	controlled	control	VERB
admet-2988	796	4	release	release	NOUN
admet-2988	796	5	343	343	NUM
admet-2988	796	6	(	(	PUNCT
admet-2988	796	7	2022	2022	NUM
admet-2988	796	8	)	)	PUNCT
admet-2988	796	9	13	13	NUM
admet-2988	796	10	-	-	SYM
admet-2988	796	11	30	30	NUM
admet-2988	796	12	.	.	PUNCT
admet-2988	797	1	https://doi.org/10.1016/j.jconrel.2022.01.011	https://doi.org/10.1016/j.jconrel.2022.01.011	PRON
admet-2988	797	2	[	[	X
admet-2988	797	3	129	129	NUM
admet-2988	797	4	]	]	X
admet-2988	797	5	b.s.p	b.s.p	PROPN
admet-2988	797	6	.	.	PUNCT
admet-2988	798	1	meihua	meihua	PROPN
admet-2988	798	2	rose	rise	VERB
admet-2988	798	3	feng	feng	PROPN
admet-2988	798	4	.	.	PUNCT
admet-2988	799	1	assessment	assessment	NOUN
admet-2988	799	2	of	of	ADP
admet-2988	799	3	blood	blood	NOUN
admet-2988	799	4	-	-	PUNCT
admet-2988	799	5	brain	brain	NOUN
admet-2988	799	6	barrier	barrier	NOUN
admet-2988	799	7	penetration	penetration	NOUN
admet-2988	799	8	:	:	PUNCT
admet-2988	799	9	in	in	ADP
admet-2988	799	10	silico	silico	NOUN
admet-2988	799	11	,	,	PUNCT
admet-2988	799	12	in	in	ADP
admet-2988	799	13	vitro	vitro	X
admet-2988	799	14	and	and	CCONJ
admet-2988	799	15	in	in	ADP
admet-2988	799	16	vivo	vivo	NOUN
admet-2988	799	17	.	.	PUNCT
admet-2988	800	1	current	current	ADJ
admet-2988	800	2	drug	drug	NOUN
admet-2988	800	3	metabolism	metabolism	NOUN
admet-2988	800	4	3	3	NUM
admet-2988	800	5	(	(	PUNCT
admet-2988	800	6	2005	2005	NUM
admet-2988	800	7	)	)	PUNCT
admet-2988	800	8	647	647	NUM
admet-2988	800	9	-	-	SYM
admet-2988	800	10	657	657	NUM
admet-2988	800	11	.	.	PUNCT
admet-2988	801	1	https://doi.org/10.2174/1389200023337063	https://doi.org/10.2174/1389200023337063	ADJ
admet-2988	801	2	https://doi.org/10.5599/admet.2988	https://doi.org/10.5599/admet.2988	X
admet-2988	801	3	https://doi.org/10.3390/molecules26020430	https://doi.org/10.3390/molecules26020430	PROPN
admet-2988	801	4	https://doi.org/10.1038/pj.2012.215	https://doi.org/10.1038/pj.2012.215	PROPN
admet-2988	801	5	https://doi.org/10.3390/polym14040712	https://doi.org/10.3390/polym14040712	ADJ
admet-2988	801	6	https://doi.org/10.1039/c8sc02415d	https://doi.org/10.1039/c8sc02415d	PROPN
admet-2988	801	7	https://doi.org/10.1039/c6cs00076b	https://doi.org/10.1039/c6cs00076b	PROPN
admet-2988	801	8	https://doi.org/10.1002/anie.201411408	https://doi.org/10.1002/anie.201411408	NUM
admet-2988	801	9	https://doi.org/10.1046/j.1432-1327.2001.02073.x	https://doi.org/10.1046/j.1432-1327.2001.02073.x	PRON
admet-2988	801	10	https://doi.org/10.3389/fnetp.2023.1190240	https://doi.org/10.3389/fnetp.2023.1190240	PROPN
admet-2988	801	11	https://doi.org/10.3389/fcvm.2021.682389	https://doi.org/10.3389/fcvm.2021.682389	PROPN
admet-2988	801	12	https://doi.org/10.1080/1061186x.2016.1223676	https://doi.org/10.1080/1061186x.2016.1223676	X
admet-2988	801	13	https://doi.org/10.1002/anie.201508445	https://doi.org/10.1002/anie.201508445	NOUN
admet-2988	801	14	https://doi.org/10.1007/s10545-013-9608-0	https://doi.org/10.1007/s10545-013-9608-0	NUM
admet-2988	801	15	https://doi.org/10.1007/s10545-013-9608-0	https://doi.org/10.1007/s10545-013-9608-0	NUM
admet-2988	801	16	https://doi.org/10.2174/1381612826666200224112534	https://doi.org/10.2174/1381612826666200224112534	NOUN
admet-2988	801	17	https://doi.org/10.1016/j.addr.2021.113859	https://doi.org/10.1016/j.addr.2021.113859	PROPN
admet-2988	801	18	https://doi.org/10.1016/j.jconrel.2022.01.011	https://doi.org/10.1016/j.jconrel.2022.01.011	PROPN
admet-2988	801	19	https://doi.org/10.2174/1389200023337063	https://doi.org/10.2174/1389200023337063	PROPN
admet-2988	801	20	r.	r.	PROPN
admet-2988	801	21	vargas	vargas	PROPN
admet-2988	801	22	et	et	PROPN
admet-2988	801	23	al	al	PROPN
admet-2988	801	24	.	.	PROPN
admet-2988	801	25	admet	admet	PROPN
admet-2988	801	26	&	&	CCONJ
admet-2988	801	27	dmpk	dmpk	PROPN
admet-2988	801	28	13(5	13(5	NUM
admet-2988	801	29	)	)	PUNCT
admet-2988	801	30	(	(	PUNCT
admet-2988	801	31	2025	2025	NUM
admet-2988	801	32	)	)	PUNCT
admet-2988	801	33	2988	2988	NUM
admet-2988	801	34	24	24	NUM
admet-2988	801	35	[	[	SYM
admet-2988	801	36	130	130	NUM
admet-2988	801	37	]	]	X
admet-2988	801	38	j.a	j.a	PROPN
admet-2988	801	39	.	.	PROPN
admet-2988	801	40	nicolazzo	nicolazzo	PROPN
admet-2988	801	41	,	,	PUNCT
admet-2988	801	42	s.a	s.a	PROPN
admet-2988	801	43	.	.	PROPN
admet-2988	801	44	charman	charman	PROPN
admet-2988	801	45	,	,	PUNCT
admet-2988	801	46	w.n	w.n	PROPN
admet-2988	801	47	.	.	PROPN
admet-2988	801	48	charman	charman	PROPN
admet-2988	801	49	.	.	PUNCT
admet-2988	802	1	methods	method	NOUN
admet-2988	802	2	to	to	PART
admet-2988	802	3	assess	assess	VERB
admet-2988	802	4	drug	drug	NOUN
admet-2988	802	5	permeability	permeability	NOUN
admet-2988	802	6	across	across	ADP
admet-2988	802	7	the	the	DET
admet-2988	802	8	bloodbrain	bloodbrain	NOUN
admet-2988	802	9	barrier	barrier	NOUN
admet-2988	802	10	.	.	PUNCT
admet-2988	803	1	journal	journal	NOUN
admet-2988	803	2	of	of	ADP
admet-2988	803	3	pharmacy	pharmacy	NOUN
admet-2988	803	4	and	and	CCONJ
admet-2988	803	5	pharmacology	pharmacology	NOUN
admet-2988	803	6	58	58	NUM
admet-2988	803	7	(	(	PUNCT
admet-2988	803	8	2010	2010	NUM
admet-2988	803	9	)	)	PUNCT
admet-2988	803	10	281	281	NUM
admet-2988	803	11	-	-	SYM
admet-2988	803	12	293	293	NUM
admet-2988	803	13	.	.	PUNCT
admet-2988	804	1	https://doi.org/10.1211/jpp.58.3.0001	https://doi.org/10.1211/jpp.58.3.0001	PROPN
admet-2988	805	1	[	[	X
admet-2988	805	2	131	131	X
admet-2988	805	3	]	]	X
admet-2988	805	4	y.	y.	PROPN
admet-2988	805	5	li	li	PROPN
admet-2988	805	6	,	,	PUNCT
admet-2988	805	7	t.	t.	PROPN
admet-2988	805	8	chen	chen	PROPN
admet-2988	805	9	,	,	PUNCT
admet-2988	805	10	x.	x.	PROPN
admet-2988	805	11	miao	miao	PROPN
admet-2988	805	12	,	,	PUNCT
admet-2988	805	13	x.	x.	NOUN
admet-2988	805	14	yi	yi	PROPN
admet-2988	805	15	,	,	PUNCT
admet-2988	805	16	x.	x.	PROPN
admet-2988	805	17	wang	wang	PROPN
admet-2988	805	18	,	,	PUNCT
admet-2988	805	19	h.	h.	PROPN
admet-2988	805	20	zhao	zhao	PROPN
admet-2988	805	21	,	,	PUNCT
admet-2988	805	22	s.m.y	s.m.y	PROPN
admet-2988	805	23	.	.	PROPN
admet-2988	805	24	lee	lee	PROPN
admet-2988	805	25	,	,	PUNCT
admet-2988	805	26	y.	y.	PROPN
admet-2988	805	27	zheng	zheng	PROPN
admet-2988	805	28	.	.	PUNCT
admet-2988	806	1	zebrafish	zebrafish	ADJ
admet-2988	806	2	:	:	PUNCT
admet-2988	806	3	a	a	DET
admet-2988	806	4	promising	promising	NOUN
admet-2988	806	5	in	in	ADP
admet-2988	806	6	vivo	vivo	NOUN
admet-2988	806	7	model	model	NOUN
admet-2988	806	8	for	for	ADP
admet-2988	806	9	assessing	assess	VERB
admet-2988	806	10	the	the	DET
admet-2988	806	11	delivery	delivery	NOUN
admet-2988	806	12	of	of	ADP
admet-2988	806	13	natural	natural	ADJ
admet-2988	806	14	products	product	NOUN
admet-2988	806	15	,	,	PUNCT
admet-2988	806	16	fluorescence	fluorescence	NOUN
admet-2988	806	17	dyes	dye	NOUN
admet-2988	806	18	and	and	CCONJ
admet-2988	806	19	drugs	drug	NOUN
admet-2988	806	20	across	across	ADP
admet-2988	806	21	the	the	DET
admet-2988	806	22	bloodbrain	bloodbrain	NOUN
admet-2988	806	23	barrier	barrier	NOUN
admet-2988	806	24	.	.	PUNCT
admet-2988	807	1	pharmacological	pharmacological	ADJ
admet-2988	807	2	research	research	NOUN
admet-2988	807	3	125	125	NUM
admet-2988	807	4	(	(	PUNCT
admet-2988	807	5	2017	2017	NUM
admet-2988	807	6	)	)	PUNCT
admet-2988	807	7	246	246	NUM
admet-2988	807	8	-	-	SYM
admet-2988	807	9	257	257	NUM
admet-2988	807	10	.	.	PUNCT
admet-2988	808	1	https://doi.org/10.1016/j.phrs.2017.08.017	https://doi.org/10.1016/j.phrs.2017.08.017	PROPN
admet-2988	808	2	[	[	X
admet-2988	808	3	132	132	NUM
admet-2988	808	4	]	]	PUNCT
admet-2988	808	5	k.	k.	PROPN
admet-2988	808	6	washida	washida	PROPN
admet-2988	808	7	,	,	PUNCT
admet-2988	808	8	y.	y.	PROPN
admet-2988	808	9	hattori	hattori	PROPN
admet-2988	808	10	,	,	PUNCT
admet-2988	808	11	m.	m.	NOUN
admet-2988	808	12	ihara	ihara	PROPN
admet-2988	808	13	.	.	PUNCT
admet-2988	809	1	animal	animal	NOUN
admet-2988	809	2	models	model	NOUN
admet-2988	809	3	of	of	ADP
admet-2988	809	4	chronic	chronic	ADJ
admet-2988	809	5	cerebral	cerebral	ADJ
admet-2988	809	6	hypoperfusion	hypoperfusion	NOUN
admet-2988	809	7	:	:	PUNCT
admet-2988	809	8	from	from	ADP
admet-2988	809	9	mouse	mouse	PROPN
admet-2988	809	10	to	to	AUX
admet-2988	809	11	primate	primate	VERB
admet-2988	809	12	.	.	PUNCT
admet-2988	810	1	international	international	ADJ
admet-2988	810	2	journal	journal	NOUN
admet-2988	810	3	of	of	ADP
admet-2988	810	4	molecular	molecular	ADJ
admet-2988	810	5	sciences	science	NOUN
admet-2988	810	6	20	20	NUM
admet-2988	810	7	(	(	PUNCT
admet-2988	810	8	2019	2019	NUM
admet-2988	810	9	)	)	PUNCT
admet-2988	810	10	6176	6176	NUM
admet-2988	810	11	.	.	PUNCT
admet-2988	811	1	https://doi.org/10.3390/ijms20246176	https://doi.org/10.3390/ijms20246176	NOUN
admet-2988	812	1	[	[	X
admet-2988	812	2	133	133	NUM
admet-2988	812	3	]	]	PUNCT
admet-2988	812	4	i.	i.	NOUN
admet-2988	812	5	puscas	puscas	PROPN
admet-2988	812	6	,	,	PUNCT
admet-2988	812	7	f.	f.	PROPN
admet-2988	812	8	bernard	bernard	PROPN
admet-2988	812	9	-	-	PUNCT
admet-2988	812	10	patrzynski	patrzynski	PROPN
admet-2988	812	11	,	,	PUNCT
admet-2988	812	12	m.	m.	PROPN
admet-2988	812	13	jutras	jutras	PROPN
admet-2988	812	14	,	,	PUNCT
admet-2988	812	15	m.a	m.a	PROPN
admet-2988	812	16	.	.	PROPN
admet-2988	812	17	lécuyer	lécuyer	PROPN
admet-2988	812	18	,	,	PUNCT
admet-2988	812	19	l.	l.	PROPN
admet-2988	812	20	bourbonnière	bourbonnière	PROPN
admet-2988	812	21	,	,	PUNCT
admet-2988	812	22	a.	a.	NOUN
admet-2988	812	23	prat	prat	NOUN
admet-2988	812	24	,	,	PUNCT
admet-2988	812	25	g.	g.	PROPN
admet-2988	812	26	leclair	leclair	PROPN
admet-2988	812	27	,	,	PUNCT
admet-2988	812	28	v.g	v.g	PROPN
admet-2988	812	29	.	.	PROPN
admet-2988	812	30	roullin	roullin	PROPN
admet-2988	812	31	.	.	PUNCT
admet-2988	813	1	ivivc	ivivc	PROPN
admet-2988	813	2	assessment	assessment	NOUN
admet-2988	813	3	of	of	ADP
admet-2988	813	4	two	two	NUM
admet-2988	813	5	mouse	mouse	NOUN
admet-2988	813	6	brain	brain	NOUN
admet-2988	813	7	endothelial	endothelial	ADJ
admet-2988	813	8	cell	cell	NOUN
admet-2988	813	9	models	model	NOUN
admet-2988	813	10	for	for	ADP
admet-2988	813	11	drug	drug	NOUN
admet-2988	813	12	screening	screening	NOUN
admet-2988	813	13	.	.	PUNCT
admet-2988	814	1	pharmaceutics	pharmaceutic	NOUN
admet-2988	814	2	11	11	NUM
admet-2988	814	3	(	(	PUNCT
admet-2988	814	4	2019	2019	NUM
admet-2988	814	5	)	)	PUNCT
admet-2988	814	6	587	587	NUM
admet-2988	814	7	.	.	PUNCT
admet-2988	815	1	https://doi.org/10.3390/pharmaceutics11110587	https://doi.org/10.3390/pharmaceutics11110587	PROPN
admet-2988	815	2	[	[	X
admet-2988	815	3	134	134	NUM
admet-2988	815	4	]	]	X
admet-2988	815	5	b.	b.	PROPN
admet-2988	815	6	cui	cui	PROPN
admet-2988	815	7	,	,	PUNCT
admet-2988	815	8	s.w	s.w	PROPN
admet-2988	815	9	.	.	PROPN
admet-2988	815	10	cho	cho	PROPN
admet-2988	815	11	.	.	PUNCT
admet-2988	816	1	blood	blood	NOUN
admet-2988	816	2	-	-	PUNCT
admet-2988	816	3	brain	brain	NOUN
admet-2988	816	4	barrier	barrier	NOUN
admet-2988	816	5	-	-	PUNCT
admet-2988	816	6	on	on	ADP
admet-2988	816	7	-	-	PUNCT
admet-2988	816	8	a	a	DET
admet-2988	816	9	-	-	PUNCT
admet-2988	816	10	chip	chip	NOUN
admet-2988	816	11	for	for	ADP
admet-2988	816	12	brain	brain	NOUN
admet-2988	816	13	disease	disease	NOUN
admet-2988	816	14	modeling	modeling	NOUN
admet-2988	816	15	and	and	CCONJ
admet-2988	816	16	drug	drug	NOUN
admet-2988	816	17	testing	testing	NOUN
admet-2988	816	18	.	.	PUNCT
admet-2988	817	1	bmb	bmb	PROPN
admet-2988	817	2	reports	report	VERB
admet-2988	817	3	55	55	NUM
admet-2988	817	4	(	(	PUNCT
admet-2988	817	5	2022	2022	NUM
admet-2988	817	6	)	)	PUNCT
admet-2988	817	7	213	213	NUM
admet-2988	817	8	https://doi.org/10.5483/bmbrep.2022.55.5.043	https://doi.org/10.5483/bmbrep.2022.55.5.043	PROPN
admet-2988	817	9	[	[	X
admet-2988	817	10	135	135	NUM
admet-2988	817	11	]	]	X
admet-2988	817	12	s.	s.	PROPN
admet-2988	817	13	kawakita	kawakita	PROPN
admet-2988	817	14	,	,	PUNCT
admet-2988	817	15	k.	k.	PROPN
admet-2988	817	16	mandal	mandal	PROPN
admet-2988	817	17	,	,	PUNCT
admet-2988	817	18	l.	l.	PROPN
admet-2988	817	19	mou	mou	PROPN
admet-2988	817	20	,	,	PUNCT
admet-2988	817	21	m.m	m.m	PROPN
admet-2988	817	22	.	.	PROPN
admet-2988	817	23	mecwan	mecwan	PROPN
admet-2988	817	24	,	,	PUNCT
admet-2988	817	25	y.	y.	PROPN
admet-2988	817	26	zhu	zhu	PROPN
admet-2988	817	27	,	,	PUNCT
admet-2988	817	28	s.	s.	PROPN
admet-2988	817	29	li	li	PROPN
admet-2988	817	30	,	,	PUNCT
admet-2988	817	31	s.	s.	PROPN
admet-2988	817	32	sharma	sharma	PROPN
admet-2988	817	33	,	,	PUNCT
admet-2988	817	34	a.l	a.l	PROPN
admet-2988	817	35	.	.	PROPN
admet-2988	817	36	hernandez	hernandez	PROPN
admet-2988	817	37	,	,	PUNCT
admet-2988	817	38	h.t	h.t	PROPN
admet-2988	817	39	.	.	PROPN
admet-2988	817	40	nguyen	nguyen	PROPN
admet-2988	817	41	,	,	PUNCT
admet-2988	817	42	s.	s.	PROPN
admet-2988	817	43	maity	maity	PROPN
admet-2988	817	44	,	,	PUNCT
admet-2988	817	45	n.r	n.r	PROPN
admet-2988	817	46	.	.	PROPN
admet-2988	817	47	de	de	PROPN
admet-2988	817	48	barros	barros	PROPN
admet-2988	817	49	,	,	PUNCT
admet-2988	817	50	a.	a.	NOUN
admet-2988	817	51	nakayama	nakayama	PROPN
admet-2988	817	52	,	,	PUNCT
admet-2988	817	53	p.	p.	NOUN
admet-2988	817	54	bandaru	bandaru	NOUN
admet-2988	817	55	,	,	PUNCT
admet-2988	817	56	s.	s.	PROPN
admet-2988	817	57	ahadian	ahadian	PROPN
admet-2988	817	58	,	,	PUNCT
admet-2988	817	59	h.j	h.j	PROPN
admet-2988	817	60	.	.	PROPN
admet-2988	817	61	kim	kim	PROPN
admet-2988	817	62	,	,	PUNCT
admet-2988	817	63	r.d	r.d	PROPN
admet-2988	817	64	.	.	PROPN
admet-2988	817	65	herculano	herculano	PROPN
admet-2988	817	66	,	,	PUNCT
admet-2988	817	67	e.	e.	PROPN
admet-2988	817	68	holler	holler	PROPN
admet-2988	817	69	,	,	PUNCT
admet-2988	817	70	v.	v.	PROPN
admet-2988	817	71	jucaud	jucaud	PROPN
admet-2988	817	72	,	,	PUNCT
admet-2988	817	73	m.r	m.r	PROPN
admet-2988	817	74	.	.	PROPN
admet-2988	817	75	dokmeci	dokmeci	PROPN
admet-2988	817	76	,	,	PUNCT
admet-2988	817	77	a.	a.	NOUN
admet-2988	817	78	khademhosseini	khademhosseini	PROPN
admet-2988	817	79	.	.	PUNCT
admet-2988	818	1	organ	organ	NOUN
admet-2988	818	2	-	-	PUNCT
admet-2988	818	3	on	on	ADP
admet-2988	818	4	-	-	PUNCT
admet-2988	818	5	a	a	DET
admet-2988	818	6	-	-	PUNCT
admet-2988	818	7	chip	chip	NOUN
admet-2988	818	8	models	model	NOUN
admet-2988	818	9	of	of	ADP
admet-2988	818	10	the	the	DET
admet-2988	818	11	blood	blood	NOUN
admet-2988	818	12	-	-	PUNCT
admet-2988	818	13	brain	brain	NOUN
admet-2988	818	14	barrier	barrier	NOUN
admet-2988	818	15	:	:	PUNCT
admet-2988	818	16	recent	recent	ADJ
admet-2988	818	17	advances	advance	NOUN
admet-2988	818	18	and	and	CCONJ
admet-2988	818	19	future	future	ADJ
admet-2988	818	20	prospects	prospect	NOUN
admet-2988	818	21	.	.	PUNCT
admet-2988	819	1	small	small	ADJ
admet-2988	819	2	18	18	NUM
admet-2988	819	3	(	(	PUNCT
admet-2988	819	4	2022	2022	NUM
admet-2988	819	5	)	)	PUNCT
admet-2988	819	6	2201401	2201401	NUM
admet-2988	819	7	.	.	PUNCT
admet-2988	820	1	https://doi.org/10.1002/smll.202201401	https://doi.org/10.1002/smll.202201401	NOUN
admet-2988	821	1	[	[	X
admet-2988	821	2	136	136	NUM
admet-2988	821	3	]	]	PUNCT
admet-2988	821	4	r.	r.	PROPN
admet-2988	821	5	vargas	vargas	PROPN
admet-2988	821	6	,	,	PUNCT
admet-2988	821	7	a.	a.	NOUN
admet-2988	821	8	egurbide	egurbide	NOUN
admet-2988	821	9	-	-	PUNCT
admet-2988	821	10	sifre	sifre	NOUN
admet-2988	821	11	,	,	PUNCT
admet-2988	821	12	l.	l.	PROPN
admet-2988	821	13	medina	medina	PROPN
admet-2988	821	14	.	.	PUNCT
admet-2988	822	1	organ	organ	PROPN
admet-2988	822	2	-	-	PUNCT
admet-2988	822	3	on	on	ADP
admet-2988	822	4	-	-	PUNCT
admet-2988	822	5	a	a	DET
admet-2988	822	6	-	-	PUNCT
admet-2988	822	7	chip	chip	NOUN
admet-2988	822	8	systems	system	NOUN
admet-2988	822	9	for	for	ADP
admet-2988	822	10	new	new	ADJ
admet-2988	822	11	drugs	drug	NOUN
admet-2988	822	12	development	development	NOUN
admet-2988	822	13	.	.	PUNCT
admet-2988	823	1	admet	admet	PROPN
admet-2988	823	2	and	and	CCONJ
admet-2988	823	3	dmpk	dmpk	X
admet-2988	823	4	9	9	NUM
admet-2988	823	5	(	(	PUNCT
admet-2988	823	6	2021	2021	NUM
admet-2988	823	7	)	)	PUNCT
admet-2988	823	8	111	111	NUM
admet-2988	823	9	-	-	SYM
admet-2988	823	10	141	141	NUM
admet-2988	823	11	.	.	PUNCT
admet-2988	824	1	https://doi.org/10.5599/admet.942	https://doi.org/10.5599/admet.942	PROPN
admet-2988	824	2	[	[	X
admet-2988	824	3	137	137	NUM
admet-2988	824	4	]	]	PUNCT
admet-2988	824	5	r.	r.	PROPN
admet-2988	824	6	mittal	mittal	PROPN
admet-2988	824	7	,	,	PUNCT
admet-2988	824	8	f.w	f.w	PROPN
admet-2988	824	9	.	.	PROPN
admet-2988	824	10	woo	woo	PROPN
admet-2988	824	11	,	,	PUNCT
admet-2988	824	12	c.s	c.s	PROPN
admet-2988	824	13	.	.	PROPN
admet-2988	824	14	castro	castro	PROPN
admet-2988	824	15	,	,	PUNCT
admet-2988	824	16	m.a	m.a	PROPN
admet-2988	824	17	.	.	PROPN
admet-2988	824	18	cohen	cohen	PROPN
admet-2988	824	19	,	,	PUNCT
admet-2988	824	20	j.	j.	PROPN
admet-2988	824	21	karanxha	karanxha	PROPN
admet-2988	824	22	,	,	PUNCT
admet-2988	824	23	j.	j.	PROPN
admet-2988	824	24	mittal	mittal	PROPN
admet-2988	824	25	,	,	PUNCT
admet-2988	824	26	t.	t.	PROPN
admet-2988	824	27	chhibber	chhibber	PROPN
admet-2988	824	28	,	,	PUNCT
admet-2988	824	29	v.m	v.m	PROPN
admet-2988	824	30	.	.	PROPN
admet-2988	824	31	jhaveri	jhaveri	PROPN
admet-2988	824	32	.	.	PUNCT
admet-2988	825	1	organ	organ	NOUN
admet-2988	825	2	-	-	PUNCT
admet-2988	825	3	on	on	ADP
admet-2988	825	4	-	-	PUNCT
admet-2988	825	5	chip	chip	NOUN
admet-2988	825	6	models	model	NOUN
admet-2988	825	7	:	:	PUNCT
admet-2988	825	8	implications	implication	NOUN
admet-2988	825	9	in	in	ADP
admet-2988	825	10	drug	drug	NOUN
admet-2988	825	11	discovery	discovery	NOUN
admet-2988	825	12	and	and	CCONJ
admet-2988	825	13	clinical	clinical	ADJ
admet-2988	825	14	applications	application	NOUN
admet-2988	825	15	.	.	PUNCT
admet-2988	826	1	journal	journal	NOUN
admet-2988	826	2	of	of	ADP
admet-2988	826	3	cellular	cellular	ADJ
admet-2988	826	4	physiology	physiology	NOUN
admet-2988	826	5	234	234	NUM
admet-2988	826	6	(	(	PUNCT
admet-2988	826	7	2019	2019	NUM
admet-2988	826	8	)	)	PUNCT
admet-2988	826	9	8352	8352	NUM
admet-2988	826	10	-	-	SYM
admet-2988	826	11	8380	8380	NUM
admet-2988	826	12	.	.	PUNCT
admet-2988	827	1	https://doi.org/10.1002/jcp.27729	https://doi.org/10.1002/jcp.27729	PROPN
admet-2988	827	2	©	©	PROPN
admet-2988	827	3	2025	2025	NUM
admet-2988	827	4	by	by	ADP
admet-2988	827	5	the	the	DET
admet-2988	827	6	authors	author	NOUN
admet-2988	827	7	;	;	PUNCT
admet-2988	827	8	licensee	licensee	PROPN
admet-2988	827	9	iapc	iapc	PROPN
admet-2988	827	10	,	,	PUNCT
admet-2988	827	11	zagreb	zagreb	PROPN
admet-2988	827	12	,	,	PUNCT
admet-2988	827	13	croatia	croatia	PROPN
admet-2988	827	14	.	.	PUNCT
admet-2988	828	1	this	this	DET
admet-2988	828	2	article	article	NOUN
admet-2988	828	3	is	be	AUX
admet-2988	828	4	an	an	DET
admet-2988	828	5	open	open	ADJ
admet-2988	828	6	-	-	PUNCT
admet-2988	828	7	access	access	NOUN
admet-2988	828	8	article	article	NOUN
admet-2988	828	9	distributed	distribute	VERB
admet-2988	828	10	under	under	ADP
admet-2988	828	11	the	the	DET
admet-2988	828	12	terms	term	NOUN
admet-2988	828	13	and	and	CCONJ
admet-2988	828	14	conditions	condition	NOUN
admet-2988	828	15	of	of	ADP
admet-2988	828	16	the	the	DET
admet-2988	828	17	creative	creative	ADJ
admet-2988	828	18	commons	common	NOUN
admet-2988	828	19	attribution	attribution	NOUN
admet-2988	828	20	license	license	NOUN
admet-2988	828	21	(	(	PUNCT
admet-2988	828	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-2988	828	23	)	)	PUNCT
admet-2988	828	24	https://doi.org/10.1211/jpp.58.3.0001	https://doi.org/10.1211/jpp.58.3.0001	PROPN
admet-2988	828	25	https://doi.org/10.1016/j.phrs.2017.08.017	https://doi.org/10.1016/j.phrs.2017.08.017	VERB
admet-2988	828	26	https://doi.org/10.3390/ijms20246176	https://doi.org/10.3390/ijms20246176	NOUN
admet-2988	828	27	https://doi.org/10.3390/pharmaceutics11110587	https://doi.org/10.3390/pharmaceutics11110587	ADJ
admet-2988	828	28	https://doi.org/10.5483/bmbrep.2022.55.5.043	https://doi.org/10.5483/bmbrep.2022.55.5.043	ADJ
admet-2988	828	29	https://doi.org/10.1002/smll.202201401	https://doi.org/10.1002/smll.202201401	NOUN
admet-2988	828	30	https://doi.org/10.5599/admet.942	https://doi.org/10.5599/admet.942	VERB
admet-2988	828	31	https://doi.org/10.1002/jcp.27729	https://doi.org/10.1002/jcp.27729	PROPN
admet-2988	828	32	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN