id	sid	tid	token	lemma	pos
admet-3	1	1	manuscript	manuscript	PROPN
admet-3	1	2	doi	doi	PROPN
admet-3	1	3	:	:	PUNCT
admet-3	1	4	10.5599	10.5599	NUM
admet-3	1	5	/	/	SYM
admet-3	1	6	admet.1.2.3	admet.1.2.3	NOUN
admet-3	1	7	6	6	NUM
admet-3	1	8	admet	admet	X
admet-3	1	9	&	&	CCONJ
admet-3	1	10	dmpk	dmpk	PROPN
admet-3	1	11	1(2	1(2	NUM
admet-3	1	12	)	)	PUNCT
admet-3	1	13	(	(	PUNCT
admet-3	1	14	2013	2013	NUM
admet-3	1	15	)	)	PUNCT
admet-3	1	16	6	6	NUM
admet-3	1	17	-	-	SYM
admet-3	1	18	16	16	NUM
admet-3	1	19	;	;	PUNCT
admet-3	1	20	doi	doi	NOUN
admet-3	1	21	:	:	PUNCT
admet-3	1	22	10.5599	10.5599	NUM
admet-3	1	23	/	/	SYM
admet-3	1	24	admet.1.2.3	admet.1.2.3	NOUN
admet-3	1	25	open	open	ADJ
admet-3	1	26	access	access	NOUN
admet-3	1	27	:	:	PUNCT
admet-3	1	28	issn	issn	PROPN
admet-3	1	29	:	:	PUNCT
admet-3	1	30	1848	1848	NUM
admet-3	1	31	-	-	SYM
admet-3	1	32	7718	7718	NUM
admet-3	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-3	1	34	original	original	ADJ
admet-3	1	35	scientific	scientific	ADJ
admet-3	1	36	paper	paper	NOUN
admet-3	1	37	physico	physico	NOUN
admet-3	1	38	-	-	PUNCT
admet-3	1	39	chemical	chemical	NOUN
admet-3	1	40	profiling	profiling	NOUN
admet-3	1	41	of	of	ADP
admet-3	1	42	the	the	DET
admet-3	1	43	ace	ace	NOUN
admet-3	1	44	-	-	PUNCT
admet-3	1	45	inhibitor	inhibitor	NOUN
admet-3	1	46	lisinopril	lisinopril	NOUN
admet-3	1	47	:	:	PUNCT
admet-3	1	48	acidbase	acidbase	ADJ
admet-3	1	49	properties	property	NOUN
admet-3	1	50	krisztina	krisztina	VERB
admet-3	1	51	takács	takács	VERB
admet-3	1	52	-	-	PUNCT
admet-3	1	53	novák	novák	PROPN
admet-3	1	54	*	*	PROPN
admet-3	1	55	,	,	PUNCT
admet-3	1	56	katalin	katalin	PROPN
admet-3	1	57	deák	deák	PROPN
admet-3	1	58	,	,	PUNCT
admet-3	1	59	szabolcs	szabolcs	PROPN
admet-3	1	60	béni	béni	PROPN
admet-3	1	61	,	,	PUNCT
admet-3	1	62	gergely	gergely	ADV
admet-3	1	63	völgyi	völgyi	PROPN
admet-3	1	64	semmelweis	semmelweis	PROPN
admet-3	1	65	university	university	PROPN
admet-3	1	66	,	,	PUNCT
admet-3	1	67	department	department	NOUN
admet-3	1	68	of	of	ADP
admet-3	1	69	pharmaceutical	pharmaceutical	ADJ
admet-3	1	70	chemistry	chemistry	NOUN
admet-3	1	71	h-1092	h-1092	PROPN
admet-3	1	72	hőgyes	hőgyes	ADV
admet-3	1	73	endre	endre	PROPN
admet-3	1	74	street	street	PROPN
admet-3	1	75	9	9	NUM
admet-3	1	76	.	.	PUNCT
admet-3	2	1	budapest	budapest	PROPN
admet-3	2	2	,	,	PUNCT
admet-3	2	3	hungary	hungary	PROPN
admet-3	2	4	*	*	PUNCT
admet-3	2	5	corresponding	correspond	VERB
admet-3	2	6	author	author	NOUN
admet-3	2	7	:	:	PUNCT
admet-3	2	8	krisztina	krisztina	PROPN
admet-3	2	9	takács	takács	VERB
admet-3	2	10	-	-	PUNCT
admet-3	2	11	novák	novák	NOUN
admet-3	2	12	;	;	PUNCT
admet-3	2	13	e	e	X
admet-3	2	14	-	-	NOUN
admet-3	2	15	mail	mail	NOUN
admet-3	2	16	:	:	PUNCT
admet-3	2	17	novak.krisztina@pharma.semmelweis-univ.hu	novak.krisztina@pharma.semmelweis-univ.hu	NUM
admet-3	2	18	;	;	PUNCT
admet-3	2	19	tel	tel	PROPN
admet-3	2	20	.	.	PUNCT
admet-3	2	21	:	:	PUNCT
admet-3	3	1	+36	+36	NOUN
admet-3	3	2	1	1	NUM
admet-3	3	3	215	215	NUM
admet-3	3	4	5241	5241	NUM
admet-3	3	5	;	;	PUNCT
admet-3	3	6	fax	fax	NOUN
admet-3	3	7	:	:	PUNCT
admet-3	3	8	+36	+36	NOUN
admet-3	3	9	1	1	NUM
admet-3	3	10	217	217	NUM
admet-3	3	11	0891	0891	NUM
admet-3	3	12	received	receive	VERB
admet-3	3	13	:	:	PUNCT
admet-3	3	14	january	january	PROPN
admet-3	3	15	7th	7th	NOUN
admet-3	3	16	,	,	PUNCT
admet-3	3	17	2013	2013	NUM
admet-3	3	18	;	;	PUNCT
admet-3	3	19	revised	revise	VERB
admet-3	3	20	:	:	PUNCT
admet-3	3	21	february	february	PROPN
admet-3	3	22	1st	1st	NOUN
admet-3	3	23	,	,	PUNCT
admet-3	3	24	2013	2013	NUM
admet-3	3	25	;	;	PUNCT
admet-3	3	26	published	publish	VERB
admet-3	3	27	:	:	PUNCT
admet-3	3	28	february	february	PROPN
admet-3	3	29	15th	15th	NOUN
admet-3	3	30	,	,	PUNCT
admet-3	3	31	2013	2013	NUM
admet-3	3	32	abstract	abstract	ADJ
admet-3	3	33	the	the	DET
admet-3	3	34	acid	acid	NOUN
admet-3	3	35	-	-	PUNCT
admet-3	3	36	base	base	NOUN
admet-3	3	37	chemistry	chemistry	NOUN
admet-3	3	38	of	of	ADP
admet-3	3	39	a	a	DET
admet-3	3	40	tetraprotic	tetraprotic	ADJ
admet-3	3	41	,	,	PUNCT
admet-3	3	42	ampholyte	ampholyte	ADJ
admet-3	3	43	ace	ace	NOUN
admet-3	3	44	inhibitor	inhibitor	NOUN
admet-3	3	45	,	,	PUNCT
admet-3	3	46	lisinopril	lisinopril	PROPN
admet-3	3	47	,	,	PUNCT
admet-3	3	48	was	be	AUX
admet-3	3	49	studied	study	VERB
admet-3	3	50	by	by	ADP
admet-3	3	51	different	different	ADJ
admet-3	3	52	methods	method	NOUN
admet-3	3	53	.	.	PUNCT
admet-3	4	1	potentiometry	potentiometry	NOUN
admet-3	4	2	in	in	ADP
admet-3	4	3	aqueous	aqueous	ADJ
admet-3	4	4	medium	medium	NOUN
admet-3	4	5	and	and	CCONJ
admet-3	4	6	a	a	DET
admet-3	4	7	co	co	ADJ
admet-3	4	8	-	-	ADJ
admet-3	4	9	solvent	solvent	ADJ
admet-3	4	10	technique	technique	NOUN
admet-3	4	11	in	in	ADP
admet-3	4	12	methanol	methanol	NOUN
admet-3	4	13	-	-	PUNCT
admet-3	4	14	water	water	NOUN
admet-3	4	15	mixtures	mixture	NOUN
admet-3	4	16	as	as	ADV
admet-3	4	17	well	well	ADV
admet-3	4	18	as	as	ADP
admet-3	4	19	1	1	NUM
admet-3	4	20	h	h	NOUN
admet-3	4	21	nmr	nmr	NOUN
admet-3	4	22	-	-	PUNCT
admet-3	4	23	ph	ph	NOUN
admet-3	4	24	titration	titration	NOUN
admet-3	4	25	were	be	AUX
admet-3	4	26	applied	apply	VERB
admet-3	4	27	for	for	ADP
admet-3	4	28	the	the	DET
admet-3	4	29	highly	highly	ADV
admet-3	4	30	precise	precise	ADJ
admet-3	4	31	measurement	measurement	NOUN
admet-3	4	32	of	of	ADP
admet-3	4	33	protonation	protonation	NOUN
admet-3	4	34	macroconstants	macroconstant	NOUN
admet-3	4	35	.	.	PUNCT
admet-3	5	1	the	the	DET
admet-3	5	2	log	log	NOUN
admet-3	5	3	k	k	PROPN
admet-3	5	4	values	value	NOUN
admet-3	5	5	of	of	ADP
admet-3	5	6	lisinopril	lisinopril	NOUN
admet-3	5	7	(	(	PUNCT
admet-3	5	8	at	at	ADP
admet-3	5	9	25.0	25.0	NUM
admet-3	5	10	°	°	NOUN
admet-3	5	11	c	c	NOUN
admet-3	5	12	and	and	CCONJ
admet-3	5	13	0.15	0.15	NUM
admet-3	5	14	m	m	NOUN
admet-3	5	15	ionic	ionic	ADJ
admet-3	5	16	strength	strength	NOUN
admet-3	5	17	)	)	PUNCT
admet-3	5	18	were	be	AUX
admet-3	5	19	found	find	VERB
admet-3	5	20	:	:	PUNCT
admet-3	5	21	log	log	VERB
admet-3	5	22	k1	k1	NOUN
admet-3	5	23	=	=	SYM
admet-3	5	24	10.75	10.75	NUM
admet-3	5	25	±	±	NUM
admet-3	5	26	0.01	0.01	NUM
admet-3	5	27	,	,	PUNCT
admet-3	5	28	log	log	VERB
admet-3	5	29	k2	k2	NOUN
admet-3	5	30	=	=	PROPN
admet-3	5	31	7.13	7.13	NUM
admet-3	5	32	±	±	NUM
admet-3	5	33	0.01	0.01	NUM
admet-3	5	34	,	,	PUNCT
admet-3	5	35	log	log	NOUN
admet-3	5	36	k3	k3	ADJ
admet-3	5	37	=	=	PROPN
admet-3	5	38	3.13	3.13	NUM
admet-3	5	39	±	±	NUM
admet-3	5	40	0.01	0.01	NUM
admet-3	5	41	,	,	PUNCT
admet-3	5	42	log	log	VERB
admet-3	5	43	k4	k4	NOUN
admet-3	5	44	=	=	PUNCT
admet-3	5	45	1.63	1.63	NUM
admet-3	5	46	±	±	NUM
admet-3	5	47	0.01	0.01	NUM
admet-3	5	48	,	,	PUNCT
admet-3	5	49	calculated	calculate	VERB
admet-3	5	50	as	as	ADP
admet-3	5	51	an	an	DET
admet-3	5	52	average	average	NOUN
admet-3	5	53	of	of	ADP
admet-3	5	54	the	the	DET
admet-3	5	55	best	good	ADJ
admet-3	5	56	two	two	NUM
admet-3	5	57	values	value	NOUN
admet-3	5	58	obtained	obtain	VERB
admet-3	5	59	by	by	ADP
admet-3	5	60	independent	independent	ADJ
admet-3	5	61	methods	method	NOUN
admet-3	5	62	.	.	PUNCT
admet-3	6	1	nmr	nmr	NOUN
admet-3	6	2	-	-	PUNCT
admet-3	6	3	ph	ph	NOUN
admet-3	6	4	titration	titration	NOUN
admet-3	6	5	was	be	AUX
admet-3	6	6	used	use	VERB
admet-3	6	7	to	to	PART
admet-3	6	8	assign	assign	VERB
admet-3	6	9	the	the	DET
admet-3	6	10	constants	constant	NOUN
admet-3	6	11	to	to	ADP
admet-3	6	12	the	the	DET
admet-3	6	13	functional	functional	ADJ
admet-3	6	14	groups	group	NOUN
admet-3	6	15	and	and	CCONJ
admet-3	6	16	for	for	ADP
admet-3	6	17	the	the	DET
admet-3	6	18	examination	examination	NOUN
admet-3	6	19	of	of	ADP
admet-3	6	20	site	site	NOUN
admet-3	6	21	-	-	PUNCT
admet-3	6	22	specific	specific	ADJ
admet-3	6	23	,	,	PUNCT
admet-3	6	24	submolecular	submolecular	ADJ
admet-3	6	25	basicities	basicitie	NOUN
admet-3	6	26	of	of	ADP
admet-3	6	27	the	the	DET
admet-3	6	28	molecule	molecule	NOUN
admet-3	6	29	(	(	PUNCT
admet-3	6	30	determination	determination	NOUN
admet-3	6	31	of	of	ADP
admet-3	6	32	protonation	protonation	NOUN
admet-3	6	33	microconstants	microconstant	NOUN
admet-3	6	34	)	)	PUNCT
admet-3	6	35	.	.	PUNCT
admet-3	7	1	in	in	ADP
admet-3	7	2	the	the	DET
admet-3	7	3	first	first	ADJ
admet-3	7	4	two	two	NUM
admet-3	7	5	well	well	ADV
admet-3	7	6	-	-	PUNCT
admet-3	7	7	separated	separate	VERB
admet-3	7	8	protonation	protonation	NOUN
admet-3	7	9	steps	step	NOUN
admet-3	7	10	,	,	PUNCT
admet-3	7	11	the	the	DET
admet-3	7	12	macroand	macroand	NOUN
admet-3	7	13	microconstants	microconstant	NOUN
admet-3	7	14	were	be	AUX
admet-3	7	15	identical	identical	ADJ
admet-3	7	16	and	and	CCONJ
admet-3	7	17	assigned	assign	VERB
admet-3	7	18	to	to	ADP
admet-3	7	19	the	the	DET
admet-3	7	20	primary	primary	ADJ
admet-3	7	21	amino	amino	NOUN
admet-3	7	22	group	group	NOUN
admet-3	7	23	(	(	PUNCT
admet-3	7	24	log	log	NOUN
admet-3	7	25	k1	k1	NOUN
admet-3	7	26	=	=	PUNCT
admet-3	7	27	log	log	NOUN
admet-3	7	28	k	k	PROPN
admet-3	7	29	a	a	NOUN
admet-3	7	30	)	)	PUNCT
admet-3	7	31	and	and	CCONJ
admet-3	7	32	to	to	ADP
admet-3	7	33	the	the	DET
admet-3	7	34	secondary	secondary	ADJ
admet-3	7	35	amine	amine	ADJ
admet-3	7	36	basicity	basicity	NOUN
admet-3	7	37	(	(	PUNCT
admet-3	7	38	log	log	PROPN
admet-3	7	39	k2	k2	PROPN
admet-3	7	40	=	=	PROPN
admet-3	7	41	log	log	NOUN
admet-3	7	42	k	k	PROPN
admet-3	7	43	b	b	PROPN
admet-3	7	44	a	a	NOUN
admet-3	7	45	)	)	PUNCT
admet-3	7	46	,	,	PUNCT
admet-3	7	47	respectively	respectively	ADV
admet-3	7	48	.	.	PUNCT
admet-3	8	1	the	the	DET
admet-3	8	2	two	two	NUM
admet-3	8	3	carboxylates	carboxylate	NOUN
admet-3	8	4	exhibited	exhibit	VERB
admet-3	8	5	overlapping	overlap	VERB
admet-3	8	6	protonation	protonation	NOUN
admet-3	8	7	characterised	characterise	VERB
admet-3	8	8	first	first	ADV
admet-3	8	9	by	by	ADP
admet-3	8	10	microconstants	microconstant	NOUN
admet-3	8	11	(	(	PUNCT
admet-3	8	12	log	log	NOUN
admet-3	8	13	d	d	X
admet-3	8	14	abk	abk	PROPN
admet-3	8	15	=	=	SYM
admet-3	8	16	2.15	2.15	NUM
admet-3	8	17	log	log	NOUN
admet-3	8	18	c	c	PROPN
admet-3	8	19	abk	abk	PROPN
admet-3	8	20	=	=	PUNCT
admet-3	8	21	3.10	3.10	NUM
admet-3	8	22	)	)	PUNCT
admet-3	8	23	,	,	PUNCT
admet-3	8	24	revealing	reveal	VERB
admet-3	8	25	that	that	SCONJ
admet-3	8	26	the	the	DET
admet-3	8	27	carboxylate	carboxylate	NOUN
admet-3	8	28	on	on	ADP
admet-3	8	29	the	the	DET
admet-3	8	30	proline	proline	NOUN
admet-3	8	31	ring	ring	NOUN
admet-3	8	32	has	have	VERB
admet-3	8	33	nine	nine	NUM
admet-3	8	34	times	time	NOUN
admet-3	8	35	greater	great	ADJ
admet-3	8	36	intrinsic	intrinsic	ADJ
admet-3	8	37	basicity	basicity	NOUN
admet-3	8	38	than	than	ADP
admet-3	8	39	the	the	DET
admet-3	8	40	carboxylate	carboxylate	NOUN
admet-3	8	41	on	on	ADP
admet-3	8	42	the	the	DET
admet-3	8	43	side	side	NOUN
admet-3	8	44	chain	chain	NOUN
admet-3	8	45	.	.	PUNCT
admet-3	9	1	the	the	DET
admet-3	9	2	distribution	distribution	NOUN
admet-3	9	3	of	of	ADP
admet-3	9	4	protonation	protonation	NOUN
admet-3	9	5	species	specie	NOUN
admet-3	9	6	(	(	PUNCT
admet-3	9	7	lis	lis	NOUN
admet-3	9	8	2	2	NUM
admet-3	9	9	;	;	PUNCT
admet-3	9	10	hlis	hli	NOUN
admet-3	9	11	;	;	PUNCT
admet-3	9	12	h2lis	h2lis	PROPN
admet-3	9	13	;	;	PUNCT
admet-3	9	14	h3lis	h3lis	PROPN
admet-3	9	15	+	+	NUM
admet-3	9	16	;	;	PUNCT
admet-3	9	17	h4lis	h4lis	PROPN
admet-3	9	18	2	2	NUM
admet-3	9	19	+	+	NUM
admet-3	9	20	)	)	PUNCT
admet-3	9	21	and	and	CCONJ
admet-3	9	22	microspecies	microspecie	NOUN
admet-3	9	23	(	(	PUNCT
admet-3	9	24	abc	abc	PROPN
admet-3	9	25	;	;	PUNCT
admet-3	9	26	abd	abd	PROPN
admet-3	9	27	)	)	PUNCT
admet-3	9	28	as	as	SCONJ
admet-3	9	29	a	a	DET
admet-3	9	30	function	function	NOUN
admet-3	9	31	of	of	ADP
admet-3	9	32	ph	ph	NOUN
admet-3	9	33	was	be	AUX
admet-3	9	34	calculated	calculate	VERB
admet-3	9	35	and	and	CCONJ
admet-3	9	36	used	use	VERB
admet-3	9	37	to	to	PART
admet-3	9	38	interpret	interpret	VERB
admet-3	9	39	the	the	DET
admet-3	9	40	pharmacokinetic	pharmacokinetic	ADJ
admet-3	9	41	and	and	CCONJ
admet-3	9	42	pharmacodynamic	pharmacodynamic	ADJ
admet-3	9	43	properties	property	NOUN
admet-3	9	44	of	of	ADP
admet-3	9	45	lisinopril	lisinopril	NOUN
admet-3	9	46	.	.	PUNCT
admet-3	10	1	keywords	keyword	VERB
admet-3	10	2	proton	proton	NOUN
admet-3	10	3	speciation	speciation	NOUN
admet-3	10	4	;	;	PUNCT
admet-3	10	5	logk	logk	NOUN
admet-3	10	6	;	;	PUNCT
admet-3	10	7	potentiometry	potentiometry	NOUN
admet-3	10	8	;	;	PUNCT
admet-3	10	9	nmr	nmr	NOUN
admet-3	10	10	-	-	PUNCT
admet-3	10	11	ph	ph	NOUN
admet-3	10	12	titration	titration	NOUN
admet-3	10	13	introduction	introduction	NOUN
admet-3	10	14	angiotensin	angiotensin	NOUN
admet-3	10	15	converting	convert	VERB
admet-3	10	16	enzyme	enzyme	NOUN
admet-3	10	17	(	(	PUNCT
admet-3	10	18	ace	ace	NOUN
admet-3	10	19	)	)	PUNCT
admet-3	10	20	inhibitors	inhibitor	NOUN
admet-3	10	21	serve	serve	VERB
admet-3	10	22	as	as	ADP
admet-3	10	23	fundamental	fundamental	ADJ
admet-3	10	24	medicines	medicine	NOUN
admet-3	10	25	in	in	ADP
admet-3	10	26	the	the	DET
admet-3	10	27	treatment	treatment	NOUN
admet-3	10	28	of	of	ADP
admet-3	10	29	hypertension	hypertension	NOUN
admet-3	10	30	,	,	PUNCT
admet-3	10	31	one	one	NUM
admet-3	10	32	of	of	ADP
admet-3	10	33	the	the	DET
admet-3	10	34	most	most	ADV
admet-3	10	35	prevalent	prevalent	ADJ
admet-3	10	36	chronic	chronic	ADJ
admet-3	10	37	diseases	disease	NOUN
admet-3	10	38	nowadays	nowadays	ADV
admet-3	10	39	.	.	PUNCT
admet-3	11	1	out	out	ADP
admet-3	11	2	of	of	ADP
admet-3	11	3	the	the	DET
admet-3	11	4	numerous	numerous	ADJ
admet-3	11	5	currently	currently	ADV
admet-3	11	6	available	available	ADJ
admet-3	11	7	ace	ace	NOUN
admet-3	11	8	-	-	PUNCT
admet-3	11	9	inhibitors	inhibitor	NOUN
admet-3	11	10	,	,	PUNCT
admet-3	11	11	lisinopril	lisinopril	NOUN
admet-3	11	12	–	–	PUNCT
admet-3	11	13	(	(	PUNCT
admet-3	11	14	2s)-1-[(2s)-6	2s)-1-[(2s)-6	NOUN
admet-3	11	15	-	-	PUNCT
admet-3	11	16	amino-2[[(1s)-1	amino-2[[(1s)-1	NOUN
admet-3	11	17	-	-	PUNCT
admet-3	11	18	carboxy-3	carboxy-3	ADJ
admet-3	11	19	-	-	PUNCT
admet-3	11	20	phenylpropyl]amino]hexanoyl]-pirrole-2	phenylpropyl]amino]hexanoyl]-pirrole-2	NOUN
admet-3	11	21	-	-	ADJ
admet-3	11	22	carboxylic	carboxylic	ADJ
admet-3	11	23	acid	acid	NOUN
admet-3	11	24	(	(	PUNCT
admet-3	11	25	fig	fig	NOUN
admet-3	11	26	.	.	NOUN
admet-3	11	27	1	1	NUM
admet-3	11	28	)	)	PUNCT
admet-3	11	29	–	–	PUNCT
admet-3	11	30	belongs	belong	VERB
admet-3	11	31	to	to	ADP
admet-3	11	32	the	the	DET
admet-3	11	33	proline	proline	NOUN
admet-3	11	34	-	-	PUNCT
admet-3	11	35	containing	contain	VERB
admet-3	11	36	structures	structure	NOUN
admet-3	11	37	.	.	PUNCT
admet-3	12	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-3	12	2	mailto:novak.krisztina@pharma.semmelweis-univ.hu	mailto:novak.krisztina@pharma.semmelweis-univ.hu	PROPN
admet-3	12	3	admet	admet	PROPN
admet-3	12	4	&	&	CCONJ
admet-3	12	5	dmpk	dmpk	PROPN
admet-3	12	6	1(2	1(2	NUM
admet-3	12	7	)	)	PUNCT
admet-3	12	8	(	(	PUNCT
admet-3	12	9	2013	2013	NUM
admet-3	12	10	)	)	PUNCT
admet-3	12	11	6	6	NUM
admet-3	12	12	-	-	SYM
admet-3	12	13	16	16	NUM
admet-3	12	14	lisinopril	lisinopril	PROPN
admet-3	12	15	speciation	speciation	NOUN
admet-3	12	16	doi	doi	NOUN
admet-3	12	17	:	:	PUNCT
admet-3	12	18	10.5599	10.5599	NUM
admet-3	12	19	/	/	SYM
admet-3	12	20	admet.1.2.3	admet.1.2.3	NOUN
admet-3	12	21	7	7	NUM
admet-3	12	22	figure	figure	NOUN
admet-3	12	23	1	1	NUM
admet-3	12	24	.	.	PUNCT
admet-3	12	25	chemical	chemical	ADJ
admet-3	12	26	structure	structure	NOUN
admet-3	12	27	of	of	ADP
admet-3	12	28	the	the	DET
admet-3	12	29	ace	ace	NOUN
admet-3	12	30	inhibitor	inhibitor	NOUN
admet-3	12	31	lisinopril	lisinopril	NOUN
admet-3	12	32	due	due	ADP
admet-3	12	33	to	to	ADP
admet-3	12	34	its	its	PRON
admet-3	12	35	safe	safe	ADJ
admet-3	12	36	and	and	CCONJ
admet-3	12	37	effective	effective	ADJ
admet-3	12	38	properties	property	NOUN
admet-3	12	39	,	,	PUNCT
admet-3	12	40	lisinopril	lisinopril	NOUN
admet-3	12	41	is	be	AUX
admet-3	12	42	widely	widely	ADV
admet-3	12	43	used	use	VERB
admet-3	12	44	in	in	ADP
admet-3	12	45	the	the	DET
admet-3	12	46	therapy	therapy	NOUN
admet-3	12	47	of	of	ADP
admet-3	12	48	essential	essential	ADJ
admet-3	12	49	hypertension	hypertension	NOUN
admet-3	12	50	,	,	PUNCT
admet-3	12	51	symptomatic	symptomatic	ADJ
admet-3	12	52	and	and	CCONJ
admet-3	12	53	asymptomatic	asymptomatic	ADJ
admet-3	12	54	left	leave	VERB
admet-3	12	55	ventricular	ventricular	ADJ
admet-3	12	56	systolic	systolic	ADJ
admet-3	12	57	dysfunction	dysfunction	NOUN
admet-3	12	58	,	,	PUNCT
admet-3	12	59	post	post	ADJ
admet-3	12	60	-	-	ADJ
admet-3	12	61	myocardial	myocardial	ADJ
admet-3	12	62	infarction	infarction	NOUN
admet-3	12	63	,	,	PUNCT
admet-3	12	64	renal	renal	ADJ
admet-3	12	65	failure	failure	NOUN
admet-3	12	66	and	and	CCONJ
admet-3	12	67	diabetic	diabetic	ADJ
admet-3	12	68	nephropathy	nephropathy	NOUN
admet-3	12	69	[	[	X
admet-3	12	70	1	1	NUM
admet-3	12	71	]	]	PUNCT
admet-3	12	72	.	.	PUNCT
admet-3	13	1	lisinopril	lisinopril	PROPN
admet-3	13	2	is	be	AUX
admet-3	13	3	administered	administer	VERB
admet-3	13	4	orally	orally	ADV
admet-3	13	5	usually	usually	ADV
admet-3	13	6	in	in	ADP
admet-3	13	7	a	a	DET
admet-3	13	8	daily	daily	ADJ
admet-3	13	9	dose	dose	NOUN
admet-3	13	10	of	of	ADP
admet-3	13	11	2.5	2.5	NUM
admet-3	13	12	-	-	SYM
admet-3	13	13	40	40	NUM
admet-3	13	14	mg	mg	NOUN
admet-3	13	15	.	.	PUNCT
admet-3	14	1	its	its	PRON
admet-3	14	2	oral	oral	ADJ
admet-3	14	3	bioavailability	bioavailability	NOUN
admet-3	14	4	is	be	AUX
admet-3	14	5	between	between	ADP
admet-3	14	6	25	25	NUM
admet-3	14	7	-	-	SYM
admet-3	14	8	30	30	NUM
admet-3	14	9	%	%	NOUN
admet-3	14	10	[	[	X
admet-3	14	11	2	2	NUM
admet-3	14	12	]	]	PUNCT
admet-3	14	13	.	.	PUNCT
admet-3	15	1	absorption	absorption	NOUN
admet-3	15	2	from	from	ADP
admet-3	15	3	the	the	DET
admet-3	15	4	gastrointestinal	gastrointestinal	ADJ
admet-3	15	5	tract	tract	NOUN
admet-3	15	6	does	do	AUX
admet-3	15	7	not	not	PART
admet-3	15	8	depend	depend	VERB
admet-3	15	9	on	on	ADP
admet-3	15	10	nutrition	nutrition	NOUN
admet-3	15	11	.	.	PUNCT
admet-3	16	1	six	six	NUM
admet-3	16	2	hours	hour	NOUN
admet-3	16	3	are	be	AUX
admet-3	16	4	needed	need	VERB
admet-3	16	5	to	to	PART
admet-3	16	6	reach	reach	VERB
admet-3	16	7	the	the	DET
admet-3	16	8	maximum	maximum	ADJ
admet-3	16	9	plasma	plasma	NOUN
admet-3	16	10	concentration	concentration	NOUN
admet-3	16	11	.	.	PUNCT
admet-3	17	1	it	it	PRON
admet-3	17	2	hardly	hardly	ADV
admet-3	17	3	binds	bind	VERB
admet-3	17	4	to	to	ADP
admet-3	17	5	plasma	plasma	NOUN
admet-3	17	6	proteins	protein	NOUN
admet-3	17	7	.	.	PUNCT
admet-3	18	1	lisinopril	lisinopril	NOUN
admet-3	18	2	is	be	AUX
admet-3	18	3	not	not	PART
admet-3	18	4	metabolised	metabolise	VERB
admet-3	18	5	,	,	PUNCT
admet-3	18	6	and	and	CCONJ
admet-3	18	7	the	the	DET
admet-3	18	8	absorbed	absorb	VERB
admet-3	18	9	drug	drug	NOUN
admet-3	18	10	is	be	AUX
admet-3	18	11	primarily	primarily	ADV
admet-3	18	12	excreted	excrete	VERB
admet-3	18	13	invariably	invariably	ADV
admet-3	18	14	in	in	ADP
admet-3	18	15	the	the	DET
admet-3	18	16	urine	urine	NOUN
admet-3	18	17	[	[	X
admet-3	18	18	3	3	NUM
admet-3	18	19	]	]	PUNCT
admet-3	18	20	.	.	PUNCT
admet-3	19	1	a	a	DET
admet-3	19	2	vast	vast	ADJ
admet-3	19	3	literature	literature	NOUN
admet-3	19	4	describes	describe	VERB
admet-3	19	5	the	the	DET
admet-3	19	6	pharmacology	pharmacology	NOUN
admet-3	19	7	,	,	PUNCT
admet-3	19	8	mechanism	mechanism	NOUN
admet-3	19	9	of	of	ADP
admet-3	19	10	action	action	NOUN
admet-3	19	11	,	,	PUNCT
admet-3	19	12	pharmacokinetics	pharmacokinetic	NOUN
admet-3	19	13	and	and	CCONJ
admet-3	19	14	analytics	analytic	NOUN
admet-3	19	15	of	of	ADP
admet-3	19	16	lisinopril	lisinopril	NOUN
admet-3	19	17	[	[	X
admet-3	19	18	3	3	NUM
admet-3	19	19	-	-	SYM
admet-3	19	20	7	7	NUM
admet-3	19	21	]	]	PUNCT
admet-3	19	22	.	.	PUNCT
admet-3	20	1	however	however	ADV
admet-3	20	2	,	,	PUNCT
admet-3	20	3	surprisingly	surprisingly	ADV
admet-3	20	4	little	little	ADJ
admet-3	20	5	information	information	NOUN
admet-3	20	6	is	be	AUX
admet-3	20	7	available	available	ADJ
admet-3	20	8	on	on	ADP
admet-3	20	9	its	its	PRON
admet-3	20	10	physico	physico	NOUN
admet-3	20	11	-	-	PUNCT
admet-3	20	12	chemical	chemical	NOUN
admet-3	20	13	properties	property	NOUN
admet-3	20	14	.	.	PUNCT
admet-3	21	1	lisinopril	lisinopril	PROPN
admet-3	21	2	is	be	AUX
admet-3	21	3	a	a	DET
admet-3	21	4	polyfunctional	polyfunctional	ADJ
admet-3	21	5	,	,	PUNCT
admet-3	21	6	ampholyte	ampholyte	ADJ
admet-3	21	7	molecule	molecule	NOUN
admet-3	21	8	,	,	PUNCT
admet-3	21	9	containing	contain	VERB
admet-3	21	10	two	two	NUM
admet-3	21	11	basic	basic	ADJ
admet-3	21	12	and	and	CCONJ
admet-3	21	13	two	two	NUM
admet-3	21	14	acidic	acidic	ADJ
admet-3	21	15	moieties	moiety	NOUN
admet-3	21	16	.	.	PUNCT
admet-3	22	1	various	various	ADJ
admet-3	22	2	data	datum	NOUN
admet-3	22	3	have	have	AUX
admet-3	22	4	been	be	AUX
admet-3	22	5	published	publish	VERB
admet-3	22	6	on	on	ADP
admet-3	22	7	its	its	PRON
admet-3	22	8	acid	acid	NOUN
admet-3	22	9	-	-	PUNCT
admet-3	22	10	base	base	NOUN
admet-3	22	11	chemistry	chemistry	NOUN
admet-3	22	12	.	.	PUNCT
admet-3	23	1	the	the	DET
admet-3	23	2	dissociation	dissociation	NOUN
admet-3	23	3	constants	constant	NOUN
admet-3	23	4	(	(	PUNCT
admet-3	23	5	pka	pka	PROPN
admet-3	23	6	values	value	NOUN
admet-3	23	7	)	)	PUNCT
admet-3	23	8	were	be	AUX
admet-3	23	9	reported	report	VERB
admet-3	23	10	by	by	ADP
admet-3	23	11	bennion	bennion	NOUN
admet-3	23	12	et	et	PROPN
admet-3	23	13	al	al	PROPN
admet-3	23	14	.	.	PUNCT
admet-3	24	1	[	[	X
admet-3	24	2	8	8	NUM
admet-3	24	3	]	]	PUNCT
admet-3	24	4	(	(	PUNCT
admet-3	24	5	1.68	1.68	NUM
admet-3	24	6	,	,	PUNCT
admet-3	24	7	3.29	3.29	NUM
admet-3	24	8	,	,	PUNCT
admet-3	24	9	7.01	7.01	NUM
admet-3	24	10	,	,	PUNCT
admet-3	24	11	11.12	11.12	NUM
admet-3	24	12	)	)	PUNCT
admet-3	24	13	and	and	CCONJ
admet-3	24	14	ip	ip	VERB
admet-3	24	15	et	et	NOUN
admet-3	24	16	al	al	PROPN
admet-3	24	17	.	.	PUNCT
admet-3	25	1	[	[	X
admet-3	25	2	9	9	NUM
admet-3	25	3	]	]	PUNCT
admet-3	25	4	(	(	PUNCT
admet-3	25	5	2.5	2.5	NUM
admet-3	25	6	,	,	PUNCT
admet-3	25	7	4.0	4.0	NUM
admet-3	25	8	,	,	PUNCT
admet-3	25	9	6.7	6.7	NUM
admet-3	25	10	,	,	PUNCT
admet-3	25	11	10.1	10.1	NUM
admet-3	25	12	)	)	PUNCT
admet-3	25	13	,	,	PUNCT
admet-3	25	14	without	without	ADP
admet-3	25	15	an	an	DET
admet-3	25	16	indication	indication	NOUN
admet-3	25	17	of	of	ADP
admet-3	25	18	the	the	DET
admet-3	25	19	experimental	experimental	ADJ
admet-3	25	20	error	error	NOUN
admet-3	25	21	and	and	CCONJ
admet-3	25	22	with	with	ADP
admet-3	25	23	no	no	DET
admet-3	25	24	assignment	assignment	NOUN
admet-3	25	25	of	of	ADP
admet-3	25	26	basicities	basicitie	NOUN
admet-3	25	27	to	to	ADP
admet-3	25	28	moieties	moiety	NOUN
admet-3	25	29	.	.	PUNCT
admet-3	26	1	gonzalez	gonzalez	PROPN
admet-3	26	2	et	et	PROPN
admet-3	26	3	al	al	PROPN
admet-3	26	4	.	.	PUNCT
admet-3	27	1	[	[	X
admet-3	27	2	10	10	NUM
admet-3	27	3	]	]	PUNCT
admet-3	27	4	assigned	assign	VERB
admet-3	27	5	the	the	DET
admet-3	27	6	measured	measured	ADJ
admet-3	27	7	pka	pka	PROPN
admet-3	27	8	values	value	NOUN
admet-3	27	9	(	(	PUNCT
admet-3	27	10	1.4	1.4	NUM
admet-3	27	11	±	±	NUM
admet-3	27	12	0.1	0.1	NUM
admet-3	27	13	,	,	PUNCT
admet-3	27	14	3.00	3.00	NUM
admet-3	27	15	±	±	NUM
admet-3	27	16	0.01	0.01	NUM
admet-3	27	17	,	,	PUNCT
admet-3	27	18	7.10	7.10	NUM
admet-3	27	19	±	±	NUM
admet-3	27	20	0.01	0.01	NUM
admet-3	27	21	,	,	PUNCT
admet-3	27	22	10.78	10.78	NUM
admet-3	27	23	±	±	NUM
admet-3	27	24	0.01	0.01	NUM
admet-3	27	25	)	)	PUNCT
admet-3	27	26	to	to	ADP
admet-3	27	27	the	the	DET
admet-3	27	28	functional	functional	ADJ
admet-3	27	29	groups	group	NOUN
admet-3	27	30	,	,	PUNCT
admet-3	27	31	but	but	CCONJ
admet-3	27	32	only	only	ADV
admet-3	27	33	on	on	ADP
admet-3	27	34	the	the	DET
admet-3	27	35	basis	basis	NOUN
admet-3	27	36	of	of	ADP
admet-3	27	37	chemical	chemical	ADJ
admet-3	27	38	evidence	evidence	NOUN
admet-3	27	39	.	.	PUNCT
admet-3	28	1	these	these	DET
admet-3	28	2	three	three	NUM
admet-3	28	3	datasets	dataset	NOUN
admet-3	28	4	of	of	ADP
admet-3	28	5	pka	pka	PROPN
admet-3	28	6	values	value	NOUN
admet-3	28	7	are	be	AUX
admet-3	28	8	significantly	significantly	ADV
admet-3	28	9	different	different	ADJ
admet-3	28	10	,	,	PUNCT
admet-3	28	11	particularly	particularly	ADV
admet-3	28	12	the	the	DET
admet-3	28	13	lowest	low	ADJ
admet-3	28	14	and	and	CCONJ
admet-3	28	15	highest	high	ADJ
admet-3	28	16	constants	constant	NOUN
admet-3	28	17	,	,	PUNCT
admet-3	28	18	which	which	PRON
admet-3	28	19	remain	remain	VERB
admet-3	28	20	uncertain	uncertain	ADJ
admet-3	28	21	.	.	PUNCT
admet-3	29	1	the	the	DET
admet-3	29	2	difference	difference	NOUN
admet-3	29	3	between	between	ADP
admet-3	29	4	them	they	PRON
admet-3	29	5	exceeds	exceed	VERB
admet-3	29	6	one	one	NUM
admet-3	29	7	order	order	NOUN
admet-3	29	8	of	of	ADP
admet-3	29	9	magnitude	magnitude	NOUN
admet-3	29	10	.	.	PUNCT
admet-3	30	1	the	the	DET
admet-3	30	2	acid	acid	NOUN
admet-3	30	3	/	/	SYM
admet-3	30	4	base	base	NOUN
admet-3	30	5	character	character	NOUN
admet-3	30	6	determines	determine	VERB
admet-3	30	7	the	the	DET
admet-3	30	8	charge	charge	NOUN
admet-3	30	9	of	of	ADP
admet-3	30	10	a	a	DET
admet-3	30	11	molecule	molecule	NOUN
admet-3	30	12	in	in	ADP
admet-3	30	13	solution	solution	NOUN
admet-3	30	14	at	at	ADP
admet-3	30	15	a	a	DET
admet-3	30	16	particular	particular	ADJ
admet-3	30	17	ph	ph	NOUN
admet-3	30	18	(	(	PUNCT
admet-3	30	19	characterised	characterise	VERB
admet-3	30	20	by	by	ADP
admet-3	30	21	the	the	DET
admet-3	30	22	dissociation	dissociation	NOUN
admet-3	30	23	/	/	SYM
admet-3	30	24	protonation	protonation	NOUN
admet-3	30	25	constant	constant	ADJ
admet-3	30	26	,	,	PUNCT
admet-3	30	27	pka	pka	PROPN
admet-3	30	28	/	/	SYM
admet-3	30	29	log	log	PROPN
admet-3	30	30	k	k	NOUN
admet-3	30	31	)	)	PUNCT
admet-3	30	32	.	.	PUNCT
admet-3	31	1	further	far	ADV
admet-3	31	2	on	on	ADV
admet-3	31	3	in	in	ADP
admet-3	31	4	this	this	DET
admet-3	31	5	paper	paper	NOUN
admet-3	31	6	,	,	PUNCT
admet-3	31	7	we	we	PRON
admet-3	31	8	use	use	VERB
admet-3	31	9	the	the	DET
admet-3	31	10	log	log	NOUN
admet-3	31	11	k	k	PROPN
admet-3	31	12	term	term	NOUN
admet-3	31	13	and	and	CCONJ
admet-3	31	14	consider	consider	VERB
admet-3	31	15	the	the	DET
admet-3	31	16	ionisation	ionisation	NOUN
admet-3	31	17	process	process	NOUN
admet-3	31	18	as	as	ADP
admet-3	31	19	an	an	DET
admet-3	31	20	association	association	NOUN
admet-3	31	21	with	with	ADP
admet-3	31	22	a	a	DET
admet-3	31	23	proton	proton	NOUN
admet-3	31	24	in	in	ADP
admet-3	31	25	all	all	DET
admet-3	31	26	acid	acid	ADJ
admet-3	31	27	-	-	PUNCT
admet-3	31	28	base	base	NOUN
admet-3	31	29	equilibria	equilibrium	NOUN
admet-3	31	30	.	.	PUNCT
admet-3	32	1	this	this	DET
admet-3	32	2	information	information	NOUN
admet-3	32	3	is	be	AUX
admet-3	32	4	important	important	ADJ
admet-3	32	5	in	in	ADP
admet-3	32	6	the	the	DET
admet-3	32	7	estimation	estimation	NOUN
admet-3	32	8	of	of	ADP
admet-3	32	9	adme	adme	NOUN
admet-3	32	10	(	(	PUNCT
admet-3	32	11	absorption	absorption	NOUN
admet-3	32	12	,	,	PUNCT
admet-3	32	13	distribution	distribution	NOUN
admet-3	32	14	,	,	PUNCT
admet-3	32	15	metabolism	metabolism	NOUN
admet-3	32	16	,	,	PUNCT
admet-3	32	17	excretion	excretion	NOUN
admet-3	32	18	)	)	PUNCT
admet-3	32	19	parameters	parameter	NOUN
admet-3	32	20	and	and	CCONJ
admet-3	32	21	the	the	DET
admet-3	32	22	interpretation	interpretation	NOUN
admet-3	32	23	of	of	ADP
admet-3	32	24	pharmacokinetic	pharmacokinetic	ADJ
admet-3	32	25	(	(	PUNCT
admet-3	32	26	pk	pk	NOUN
admet-3	32	27	)	)	PUNCT
admet-3	32	28	properties	property	NOUN
admet-3	32	29	.	.	PUNCT
admet-3	33	1	log	log	PROPN
admet-3	33	2	k	k	PROPN
admet-3	33	3	values	value	NOUN
admet-3	33	4	can	can	AUX
admet-3	33	5	be	be	AUX
admet-3	33	6	used	use	VERB
admet-3	33	7	to	to	PART
admet-3	33	8	better	well	ADV
admet-3	33	9	understand	understand	VERB
admet-3	33	10	the	the	DET
admet-3	33	11	binding	bind	VERB
admet-3	33	12	mechanism	mechanism	NOUN
admet-3	33	13	in	in	ADP
admet-3	33	14	therapeutic	therapeutic	ADJ
admet-3	33	15	events	event	NOUN
admet-3	33	16	and	and	CCONJ
admet-3	33	17	also	also	ADV
admet-3	33	18	for	for	ADP
admet-3	33	19	optimisation	optimisation	NOUN
admet-3	33	20	of	of	ADP
admet-3	33	21	chemical	chemical	ADJ
admet-3	33	22	reactions	reaction	NOUN
admet-3	33	23	and	and	CCONJ
admet-3	33	24	analytical	analytical	ADJ
admet-3	33	25	methods	method	NOUN
admet-3	33	26	.	.	PUNCT
admet-3	34	1	several	several	ADJ
admet-3	34	2	analytical	analytical	ADJ
admet-3	34	3	methods	method	NOUN
admet-3	34	4	have	have	AUX
admet-3	34	5	been	be	AUX
admet-3	34	6	applied	apply	VERB
admet-3	34	7	for	for	ADP
admet-3	34	8	the	the	DET
admet-3	34	9	determination	determination	NOUN
admet-3	34	10	of	of	ADP
admet-3	34	11	lisinopril	lisinopril	NOUN
admet-3	34	12	in	in	ADP
admet-3	34	13	biological	biological	ADJ
admet-3	34	14	samples	sample	NOUN
admet-3	34	15	and	and	CCONJ
admet-3	34	16	pharmaceutical	pharmaceutical	NOUN
admet-3	34	17	preparations	preparation	NOUN
admet-3	34	18	such	such	ADJ
admet-3	34	19	as	as	ADP
admet-3	34	20	alkalimetry	alkalimetry	NOUN
admet-3	34	21	[	[	X
admet-3	34	22	11	11	NUM
admet-3	34	23	]	]	PUNCT
admet-3	34	24	,	,	PUNCT
admet-3	34	25	spectrophotometry	spectrophotometry	NOUN
admet-3	34	26	[	[	X
admet-3	34	27	12	12	NUM
admet-3	34	28	]	]	PUNCT
admet-3	34	29	,	,	PUNCT
admet-3	34	30	high	high	ADJ
admet-3	34	31	performance	performance	NOUN
admet-3	34	32	liquid	liquid	NOUN
admet-3	34	33	chromatography	chromatography	NOUN
admet-3	34	34	(	(	PUNCT
admet-3	34	35	hplc	hplc	PROPN
admet-3	34	36	)	)	PUNCT
admet-3	35	1	[	[	X
admet-3	35	2	13	13	NUM
admet-3	35	3	]	]	PUNCT
admet-3	35	4	,	,	PUNCT
admet-3	35	5	high	high	ADJ
admet-3	35	6	performance	performance	NOUN
admet-3	35	7	thin	thin	ADJ
admet-3	35	8	-	-	PUNCT
admet-3	35	9	layer	layer	NOUN
admet-3	35	10	chromatography	chromatography	NOUN
admet-3	35	11	(	(	PUNCT
admet-3	35	12	hptlc	hptlc	NOUN
admet-3	35	13	)	)	PUNCT
admet-3	36	1	[	[	X
admet-3	36	2	14	14	NUM
admet-3	36	3	]	]	PUNCT
admet-3	36	4	,	,	PUNCT
admet-3	36	5	and	and	CCONJ
admet-3	36	6	capillary	capillary	ADJ
admet-3	36	7	electrophoresis	electrophoresis	NOUN
admet-3	36	8	(	(	PUNCT
admet-3	36	9	ce	ce	PROPN
admet-3	36	10	)	)	PUNCT
admet-3	37	1	[	[	X
admet-3	37	2	15	15	NUM
admet-3	37	3	]	]	PUNCT
admet-3	37	4	.	.	PUNCT
admet-3	38	1	obviously	obviously	ADV
admet-3	38	2	,	,	PUNCT
admet-3	38	3	upon	upon	SCONJ
admet-3	38	4	the	the	DET
admet-3	38	5	application	application	NOUN
admet-3	38	6	of	of	ADP
admet-3	38	7	these	these	DET
admet-3	38	8	methods	method	NOUN
admet-3	38	9	,	,	PUNCT
admet-3	38	10	exact	exact	ADJ
admet-3	38	11	knowledge	knowledge	NOUN
admet-3	38	12	of	of	ADP
admet-3	38	13	acid	acid	NOUN
admet-3	38	14	-	-	PUNCT
admet-3	38	15	base	base	NOUN
admet-3	38	16	chemistry	chemistry	NOUN
admet-3	38	17	is	be	AUX
admet-3	38	18	essential	essential	ADJ
admet-3	38	19	(	(	PUNCT
admet-3	38	20	for	for	ADP
admet-3	38	21	pharmacopoeial	pharmacopoeial	ADJ
admet-3	38	22	methods	method	NOUN
admet-3	38	23	)	)	PUNCT
admet-3	38	24	or	or	CCONJ
admet-3	38	25	at	at	ADP
admet-3	38	26	least	least	ADJ
admet-3	38	27	favourable	favourable	ADJ
admet-3	38	28	(	(	PUNCT
admet-3	38	29	for	for	ADP
admet-3	38	30	chromatographic	chromatographic	ADJ
admet-3	38	31	techniques	technique	NOUN
admet-3	38	32	and	and	CCONJ
admet-3	38	33	ce	ce	PROPN
admet-3	38	34	)	)	PUNCT
admet-3	38	35	.	.	PUNCT
admet-3	39	1	the	the	DET
admet-3	39	2	acidity	acidity	NOUN
admet-3	39	3	/	/	SYM
admet-3	39	4	basicity	basicity	NOUN
admet-3	39	5	of	of	ADP
admet-3	39	6	monovalent	monovalent	NOUN
admet-3	39	7	compounds	compound	NOUN
admet-3	39	8	can	can	AUX
admet-3	39	9	be	be	AUX
admet-3	39	10	quantified	quantify	VERB
admet-3	39	11	in	in	ADP
admet-3	39	12	terms	term	NOUN
admet-3	39	13	of	of	ADP
admet-3	39	14	macroscopic	macroscopic	ADJ
admet-3	39	15	log	log	NOUN
admet-3	39	16	k	k	PROPN
admet-3	39	17	parameters	parameter	NOUN
admet-3	39	18	(	(	PUNCT
admet-3	39	19	macroconstants	macroconstants	PROPN
admet-3	39	20	)	)	PUNCT
admet-3	39	21	.	.	PUNCT
admet-3	40	1	for	for	ADP
admet-3	40	2	multiprotic	multiprotic	ADJ
admet-3	40	3	compounds	compound	NOUN
admet-3	40	4	,	,	PUNCT
admet-3	40	5	macroconstants	macroconstant	NOUN
admet-3	40	6	characterise	characterise	VERB
admet-3	40	7	the	the	DET
admet-3	40	8	basicity	basicity	NOUN
admet-3	40	9	of	of	ADP
admet-3	40	10	the	the	DET
admet-3	40	11	molecule	molecule	NOUN
admet-3	40	12	as	as	ADP
admet-3	40	13	a	a	DET
admet-3	40	14	whole	whole	NOUN
admet-3	40	15	.	.	PUNCT
admet-3	41	1	they	they	PRON
admet-3	41	2	refer	refer	VERB
admet-3	41	3	to	to	ADP
admet-3	41	4	the	the	DET
admet-3	41	5	stoichiometric	stoichiometric	ADJ
admet-3	41	6	composition	composition	NOUN
admet-3	41	7	of	of	ADP
admet-3	41	8	the	the	DET
admet-3	41	9	species	specie	NOUN
admet-3	41	10	,	,	PUNCT
admet-3	41	11	but	but	CCONJ
admet-3	41	12	they	they	PRON
admet-3	41	13	fail	fail	VERB
admet-3	41	14	to	to	PART
admet-3	41	15	provide	provide	VERB
admet-3	41	16	information	information	NOUN
admet-3	41	17	on	on	ADP
admet-3	41	18	specific	specific	ADJ
admet-3	41	19	proton	proton	NOUN
admet-3	41	20	-	-	PUNCT
admet-3	41	21	binding	bind	VERB
admet-3	41	22	sites	site	NOUN
admet-3	41	23	.	.	PUNCT
admet-3	42	1	site	site	NOUN
admet-3	42	2	-	-	PUNCT
admet-3	42	3	specific	specific	ADJ
admet-3	42	4	,	,	PUNCT
admet-3	42	5	submolecular	submolecular	ADJ
admet-3	42	6	basicities	basicitie	NOUN
admet-3	42	7	can	can	AUX
admet-3	42	8	be	be	AUX
admet-3	42	9	obtained	obtain	VERB
admet-3	42	10	when	when	SCONJ
admet-3	42	11	krisztina	krisztina	AUX
admet-3	42	12	takács	takács	VERB
admet-3	42	13	novák	novák	PROPN
admet-3	42	14	et	et	PROPN
admet-3	42	15	al	al	PROPN
admet-3	42	16	.	.	PROPN
admet-3	42	17	admet	admet	PROPN
admet-3	42	18	&	&	CCONJ
admet-3	42	19	dmpk	dmpk	PROPN
admet-3	42	20	1(2	1(2	NUM
admet-3	42	21	)	)	PUNCT
admet-3	42	22	(	(	PUNCT
admet-3	42	23	2013	2013	NUM
admet-3	42	24	)	)	PUNCT
admet-3	42	25	6	6	NUM
admet-3	42	26	-	-	SYM
admet-3	42	27	16	16	NUM
admet-3	42	28	8	8	NUM
admet-3	42	29	microconstants	microconstant	NOUN
admet-3	42	30	are	be	AUX
admet-3	42	31	determined	determine	VERB
admet-3	42	32	.	.	PUNCT
admet-3	43	1	microconstants	microconstant	NOUN
admet-3	43	2	measure	measure	VERB
admet-3	43	3	the	the	DET
admet-3	43	4	proton	proton	NOUN
admet-3	43	5	affinity	affinity	NOUN
admet-3	43	6	of	of	ADP
admet-3	43	7	individual	individual	ADJ
admet-3	43	8	groups	group	NOUN
admet-3	43	9	,	,	PUNCT
admet-3	43	10	while	while	SCONJ
admet-3	43	11	the	the	DET
admet-3	43	12	protonation	protonation	NOUN
admet-3	43	13	states	state	NOUN
admet-3	43	14	of	of	ADP
admet-3	43	15	all	all	DET
admet-3	43	16	other	other	ADJ
admet-3	43	17	sites	site	NOUN
admet-3	43	18	are	be	AUX
admet-3	43	19	definite	definite	ADJ
admet-3	43	20	in	in	ADP
admet-3	43	21	the	the	DET
admet-3	43	22	molecule	molecule	NOUN
admet-3	44	1	[	[	X
admet-3	44	2	16	16	NUM
admet-3	44	3	]	]	PUNCT
admet-3	44	4	.	.	PUNCT
admet-3	45	1	the	the	DET
admet-3	45	2	macroscopic	macroscopic	ADJ
admet-3	45	3	and	and	CCONJ
admet-3	45	4	microscopic	microscopic	ADJ
admet-3	45	5	basicities	basicitie	NOUN
admet-3	45	6	provide	provide	VERB
admet-3	45	7	authentic	authentic	ADJ
admet-3	45	8	information	information	NOUN
admet-3	45	9	on	on	ADP
admet-3	45	10	propensities	propensity	NOUN
admet-3	45	11	of	of	ADP
admet-3	45	12	intermolecular	intermolecular	ADJ
admet-3	45	13	interactions	interaction	NOUN
admet-3	45	14	both	both	CCONJ
admet-3	45	15	in	in	ADP
admet-3	45	16	pharmacokinetic	pharmacokinetic	ADJ
admet-3	45	17	(	(	PUNCT
admet-3	45	18	pk	pk	NOUN
admet-3	45	19	)	)	PUNCT
admet-3	45	20	and	and	CCONJ
admet-3	45	21	pharmacodynamic	pharmacodynamic	ADJ
admet-3	45	22	(	(	PUNCT
admet-3	45	23	pd	pd	NOUN
admet-3	45	24	)	)	PUNCT
admet-3	45	25	stages	stage	NOUN
admet-3	45	26	[	[	X
admet-3	45	27	17	17	NUM
admet-3	45	28	]	]	PUNCT
admet-3	45	29	.	.	PUNCT
admet-3	46	1	as	as	ADP
admet-3	46	2	a	a	DET
admet-3	46	3	part	part	NOUN
admet-3	46	4	of	of	ADP
admet-3	46	5	our	our	PRON
admet-3	46	6	studies	study	NOUN
admet-3	46	7	on	on	ADP
admet-3	46	8	the	the	DET
admet-3	46	9	physico	physico	NOUN
admet-3	46	10	-	-	PUNCT
admet-3	46	11	chemical	chemical	NOUN
admet-3	46	12	properties	property	NOUN
admet-3	46	13	of	of	ADP
admet-3	46	14	ace	ace	ADJ
admet-3	46	15	inhibitors	inhibitor	NOUN
admet-3	46	16	,	,	PUNCT
admet-3	46	17	we	we	PRON
admet-3	46	18	investigated	investigate	VERB
admet-3	46	19	the	the	DET
admet-3	46	20	acidbase	acidbase	ADJ
admet-3	46	21	chemistry	chemistry	NOUN
admet-3	46	22	of	of	ADP
admet-3	46	23	lisinopril	lisinopril	NOUN
admet-3	46	24	.	.	PUNCT
admet-3	47	1	we	we	PRON
admet-3	47	2	characterised	characterise	VERB
admet-3	47	3	both	both	CCONJ
admet-3	47	4	the	the	DET
admet-3	47	5	overall	overall	NOUN
admet-3	47	6	and	and	CCONJ
admet-3	47	7	the	the	DET
admet-3	47	8	group	group	NOUN
admet-3	47	9	-	-	PUNCT
admet-3	47	10	specific	specific	ADJ
admet-3	47	11	basicities	basicitie	NOUN
admet-3	47	12	of	of	ADP
admet-3	47	13	lisinopril	lisinopril	NOUN
admet-3	47	14	.	.	PUNCT
admet-3	48	1	validated	validate	VERB
admet-3	48	2	potentiometric	potentiometric	ADJ
admet-3	48	3	methods	method	NOUN
admet-3	48	4	and	and	CCONJ
admet-3	48	5	1	1	NUM
admet-3	48	6	h	h	NOUN
admet-3	48	7	nmr	nmr	NOUN
admet-3	48	8	spectroscopy	spectroscopy	NOUN
admet-3	48	9	resulted	result	VERB
admet-3	48	10	in	in	ADP
admet-3	48	11	more	more	ADV
admet-3	48	12	precise	precise	ADJ
admet-3	48	13	macroconstants	macroconstant	NOUN
admet-3	48	14	than	than	ADP
admet-3	48	15	in	in	ADP
admet-3	48	16	previous	previous	ADJ
admet-3	48	17	investigations	investigation	NOUN
admet-3	48	18	.	.	PUNCT
admet-3	49	1	here	here	ADV
admet-3	49	2	,	,	PUNCT
admet-3	49	3	we	we	PRON
admet-3	49	4	first	first	ADV
admet-3	49	5	studied	study	VERB
admet-3	49	6	the	the	DET
admet-3	49	7	site	site	NOUN
admet-3	49	8	-	-	PUNCT
admet-3	49	9	specific	specific	ADJ
admet-3	49	10	(	(	PUNCT
admet-3	49	11	microscopic	microscopic	ADJ
admet-3	49	12	)	)	PUNCT
admet-3	49	13	protonation	protonation	NOUN
admet-3	49	14	equilibria	equilibrium	NOUN
admet-3	49	15	of	of	ADP
admet-3	49	16	lisinopril	lisinopril	NOUN
admet-3	49	17	considering	consider	VERB
admet-3	49	18	the	the	DET
admet-3	49	19	overlapping	overlap	VERB
admet-3	49	20	protonation	protonation	NOUN
admet-3	49	21	of	of	ADP
admet-3	49	22	carboxylates	carboxylate	NOUN
admet-3	49	23	.	.	PUNCT
admet-3	50	1	the	the	DET
admet-3	50	2	results	result	NOUN
admet-3	50	3	were	be	AUX
admet-3	50	4	used	use	VERB
admet-3	50	5	to	to	PART
admet-3	50	6	interpret	interpret	VERB
admet-3	50	7	the	the	DET
admet-3	50	8	pk	pk	PROPN
admet-3	50	9	/	/	SYM
admet-3	50	10	pd	pd	NOUN
admet-3	50	11	properties	property	NOUN
admet-3	50	12	of	of	ADP
admet-3	50	13	the	the	DET
admet-3	50	14	compound	compound	NOUN
admet-3	50	15	.	.	PUNCT
admet-3	51	1	experimental	experimental	ADJ
admet-3	51	2	materials	material	NOUN
admet-3	51	3	and	and	CCONJ
admet-3	51	4	instrumentation	instrumentation	NOUN
admet-3	51	5	lisinopril	lisinopril	PROPN
admet-3	51	6	dihydrate	dihydrate	NOUN
admet-3	51	7	was	be	AUX
admet-3	51	8	generously	generously	ADV
admet-3	51	9	supplied	supply	VERB
admet-3	51	10	by	by	ADP
admet-3	51	11	gedeon	gedeon	PROPN
admet-3	51	12	richter	richter	PROPN
admet-3	51	13	ltd	ltd	PROPN
admet-3	51	14	.	.	PROPN
admet-3	52	1	(	(	PUNCT
admet-3	52	2	budapest	budapest	PROPN
admet-3	52	3	,	,	PUNCT
admet-3	52	4	hungary	hungary	PROPN
admet-3	52	5	)	)	PUNCT
admet-3	52	6	and	and	CCONJ
admet-3	52	7	used	use	VERB
admet-3	52	8	without	without	ADP
admet-3	52	9	further	further	ADJ
admet-3	52	10	purification	purification	NOUN
admet-3	52	11	.	.	PUNCT
admet-3	53	1	distilled	distil	VERB
admet-3	53	2	water	water	NOUN
admet-3	53	3	was	be	AUX
admet-3	53	4	of	of	ADP
admet-3	53	5	pharmacopoeial	pharmacopoeial	ADJ
admet-3	53	6	grade	grade	NOUN
admet-3	53	7	[	[	X
admet-3	53	8	11	11	NUM
admet-3	53	9	]	]	PUNCT
admet-3	53	10	and	and	CCONJ
admet-3	53	11	all	all	DET
admet-3	53	12	other	other	ADJ
admet-3	53	13	reagents	reagent	NOUN
admet-3	53	14	of	of	ADP
admet-3	53	15	analytical	analytical	ADJ
admet-3	53	16	grade	grade	NOUN
admet-3	53	17	were	be	AUX
admet-3	53	18	purchased	purchase	VERB
admet-3	53	19	from	from	ADP
admet-3	53	20	commercial	commercial	ADJ
admet-3	53	21	suppliers	supplier	NOUN
admet-3	53	22	.	.	PUNCT
admet-3	54	1	potentiometric	potentiometric	ADJ
admet-3	54	2	titrations	titration	NOUN
admet-3	54	3	were	be	AUX
admet-3	54	4	carried	carry	VERB
admet-3	54	5	out	out	ADP
admet-3	54	6	on	on	ADP
admet-3	54	7	a	a	DET
admet-3	54	8	glpka	glpka	NOUN
admet-3	54	9	automated	automate	VERB
admet-3	54	10	pka	pka	PROPN
admet-3	54	11	and	and	CCONJ
admet-3	54	12	log	log	VERB
admet-3	54	13	p	p	NOUN
admet-3	54	14	analyser	analyser	NOUN
admet-3	54	15	(	(	PUNCT
admet-3	54	16	sirius	sirius	PROPN
admet-3	54	17	analytical	analytical	PROPN
admet-3	54	18	instr	instr	PROPN
admet-3	54	19	.	.	PUNCT
admet-3	54	20	ltd	ltd	PROPN
admet-3	54	21	.	.	PROPN
admet-3	54	22	forest	forest	PROPN
admet-3	54	23	row	row	NOUN
admet-3	54	24	,	,	PUNCT
admet-3	54	25	uk	uk	PROPN
admet-3	54	26	)	)	PUNCT
admet-3	54	27	.	.	PUNCT
admet-3	55	1	nmr	nmr	NOUN
admet-3	55	2	measurements	measurement	NOUN
admet-3	55	3	were	be	AUX
admet-3	55	4	carried	carry	VERB
admet-3	55	5	out	out	ADP
admet-3	55	6	on	on	ADP
admet-3	55	7	a	a	DET
admet-3	55	8	600	600	NUM
admet-3	55	9	mhz	mhz	NOUN
admet-3	55	10	varian	varian	PROPN
admet-3	55	11	inova	inova	PROPN
admet-3	55	12	spectrometer	spectrometer	PROPN
admet-3	55	13	(	(	PUNCT
admet-3	55	14	palo	palo	PROPN
admet-3	55	15	alto	alto	PROPN
admet-3	55	16	,	,	PUNCT
admet-3	55	17	ca	ca	NOUN
admet-3	55	18	)	)	PUNCT
admet-3	55	19	,	,	PUNCT
admet-3	55	20	equipped	equip	VERB
admet-3	55	21	with	with	ADP
admet-3	55	22	a	a	DET
admet-3	55	23	broadband	broadband	NOUN
admet-3	55	24	inverse	inverse	NOUN
admet-3	55	25	detection	detection	NOUN
admet-3	55	26	pulse	pulse	NOUN
admet-3	55	27	field	field	NOUN
admet-3	55	28	gradient	gradient	NOUN
admet-3	55	29	probehead	probehead	NOUN
admet-3	55	30	.	.	PUNCT
admet-3	56	1	potentiometric	potentiometric	ADJ
admet-3	56	2	logk	logk	ADJ
admet-3	56	3	determination	determination	NOUN
admet-3	56	4	electrode	electrode	NOUN
admet-3	56	5	calibration	calibration	NOUN
admet-3	56	6	the	the	DET
admet-3	56	7	four	four	NUM
admet-3	56	8	-	-	PUNCT
admet-3	56	9	parameter	parameter	NOUN
admet-3	56	10	procedure	procedure	NOUN
admet-3	56	11	was	be	AUX
admet-3	56	12	used	use	VERB
admet-3	56	13	for	for	ADP
admet-3	56	14	electrode	electrode	ADJ
admet-3	56	15	standardisation	standardisation	NOUN
admet-3	56	16	in	in	ADP
admet-3	56	17	both	both	CCONJ
admet-3	56	18	aqueous	aqueous	ADJ
admet-3	56	19	and	and	CCONJ
admet-3	56	20	semiaqueous	semiaqueous	ADJ
admet-3	56	21	media	medium	NOUN
admet-3	56	22	[	[	X
admet-3	56	23	18	18	NUM
admet-3	56	24	]	]	PUNCT
admet-3	56	25	.	.	PUNCT
admet-3	57	1	hcl	hcl	PROPN
admet-3	57	2	solutions	solution	NOUN
admet-3	57	3	of	of	ADP
admet-3	57	4	known	know	VERB
admet-3	57	5	concentration	concentration	NOUN
admet-3	57	6	,	,	PUNCT
admet-3	57	7	containing	contain	VERB
admet-3	57	8	0–45.68	0–45.68	ADJ
admet-3	57	9	wt%	wt%	ADJ
admet-3	57	10	methanol	methanol	NOUN
admet-3	57	11	,	,	PUNCT
admet-3	57	12	were	be	AUX
admet-3	57	13	titrated	titrate	VERB
admet-3	57	14	with	with	ADP
admet-3	57	15	standardised	standardised	ADJ
admet-3	57	16	koh	koh	PROPN
admet-3	57	17	at	at	ADP
admet-3	57	18	25.0	25.0	NUM
admet-3	57	19	±	±	NUM
admet-3	57	20	0.1	0.1	NUM
admet-3	57	21	oc	oc	NOUN
admet-3	57	22	,	,	PUNCT
admet-3	57	23	at	at	ADP
admet-3	57	24	0.15	0.15	NUM
admet-3	57	25	m	m	NOUN
admet-3	57	26	ionic	ionic	ADJ
admet-3	57	27	strength	strength	NOUN
admet-3	57	28	using	use	VERB
admet-3	57	29	kcl	kcl	NOUN
admet-3	57	30	,	,	PUNCT
admet-3	57	31	under	under	ADP
admet-3	57	32	an	an	DET
admet-3	57	33	n2	n2	ADJ
admet-3	57	34	atmosphere	atmosphere	NOUN
admet-3	57	35	,	,	PUNCT
admet-3	57	36	in	in	ADP
admet-3	57	37	the	the	DET
admet-3	57	38	ph	ph	ADJ
admet-3	57	39	interval	interval	NOUN
admet-3	57	40	of	of	ADP
admet-3	57	41	1.8	1.8	NUM
admet-3	57	42	-	-	SYM
admet-3	57	43	12.2	12.2	NUM
admet-3	57	44	.	.	PUNCT
admet-3	58	1	the	the	DET
admet-3	58	2	operational	operational	ADJ
admet-3	58	3	ph	ph	ADJ
admet-3	58	4	reading	reading	NOUN
admet-3	58	5	was	be	AUX
admet-3	58	6	related	relate	VERB
admet-3	58	7	to	to	ADP
admet-3	58	8	pch	pch	ADJ
admet-3	58	9	values	value	NOUN
admet-3	58	10	by	by	ADP
admet-3	58	11	the	the	DET
admet-3	58	12	standard	standard	ADJ
admet-3	58	13	multiparametric	multiparametric	ADJ
admet-3	58	14	equation	equation	NOUN
admet-3	58	15	:	:	PUNCT
admet-3	59	1	ph	ph	PROPN
admet-3	59	2	=	=	PUNCT
admet-3	59	3	a	a	DET
admet-3	59	4	+	+	CCONJ
admet-3	59	5	spch	spch	ADJ
admet-3	59	6	+	+	CCONJ
admet-3	59	7	jh[h+	jh[h+	PROPN
admet-3	59	8	]	]	X
admet-3	60	1	+	+	NUM
admet-3	60	2	johkw/[h+	johkw/[h+	NOUN
admet-3	60	3	]	]	PUNCT
admet-3	60	4	(	(	PUNCT
admet-3	60	5	1	1	X
admet-3	60	6	)	)	PUNCT
admet-3	60	7	where	where	SCONJ
admet-3	60	8	a	a	DET
admet-3	60	9	corresponds	correspond	NOUN
admet-3	60	10	to	to	ADP
admet-3	60	11	the	the	DET
admet-3	60	12	negative	negative	ADJ
admet-3	60	13	logarithm	logarithm	NOUN
admet-3	60	14	of	of	ADP
admet-3	60	15	the	the	DET
admet-3	60	16	activity	activity	NOUN
admet-3	60	17	coefficient	coefficient	NOUN
admet-3	60	18	of	of	ADP
admet-3	60	19	[	[	X
admet-3	60	20	h+	h+	X
admet-3	60	21	]	]	X
admet-3	60	22	at	at	ADP
admet-3	60	23	working	work	VERB
admet-3	60	24	temperature	temperature	NOUN
admet-3	60	25	and	and	CCONJ
admet-3	60	26	ionic	ionic	ADJ
admet-3	60	27	strength	strength	NOUN
admet-3	60	28	and	and	CCONJ
admet-3	60	29	s	s	NOUN
admet-3	60	30	is	be	AUX
admet-3	60	31	the	the	DET
admet-3	60	32	ratio	ratio	NOUN
admet-3	60	33	between	between	ADP
admet-3	60	34	the	the	DET
admet-3	60	35	electrode	electrode	NOUN
admet-3	60	36	slope	slope	NOUN
admet-3	60	37	and	and	CCONJ
admet-3	60	38	the	the	DET
admet-3	60	39	nernst	nernst	PROPN
admet-3	60	40	slope	slope	NOUN
admet-3	60	41	.	.	PUNCT
admet-3	61	1	the	the	DET
admet-3	61	2	jh	jh	PROPN
admet-3	61	3	and	and	CCONJ
admet-3	61	4	joh	joh	PROPN
admet-3	61	5	terms	term	NOUN
admet-3	61	6	correct	correct	VERB
admet-3	61	7	the	the	DET
admet-3	61	8	electrode	electrode	NOUN
admet-3	61	9	junction	junction	NOUN
admet-3	61	10	effects	effect	NOUN
admet-3	61	11	at	at	ADP
admet-3	61	12	low	low	ADJ
admet-3	61	13	and	and	CCONJ
admet-3	61	14	high	high	ADJ
admet-3	61	15	ph	ph	VERB
admet-3	61	16	,	,	PUNCT
admet-3	61	17	respectively	respectively	ADV
admet-3	61	18	.	.	PUNCT
admet-3	62	1	the	the	DET
admet-3	62	2	parameters	parameter	NOUN
admet-3	62	3	were	be	AUX
admet-3	62	4	determined	determine	VERB
admet-3	62	5	by	by	ADP
admet-3	62	6	a	a	DET
admet-3	62	7	weighted	weighted	ADJ
admet-3	62	8	non	non	ADJ
admet-3	62	9	-	-	ADJ
admet-3	62	10	linear	linear	ADJ
admet-3	62	11	least	least	ADJ
admet-3	62	12	squares	square	NOUN
admet-3	62	13	procedure	procedure	NOUN
admet-3	62	14	(	(	PUNCT
admet-3	62	15	refinement	refinement	NOUN
admet-3	62	16	protm	protm	NOUN
admet-3	62	17	2.2	2.2	NUM
admet-3	62	18	software	software	NOUN
admet-3	62	19	sirius	sirius	PROPN
admet-3	62	20	analytical	analytical	PROPN
admet-3	62	21	instr	instr	PROPN
admet-3	62	22	.	.	PUNCT
admet-3	62	23	ltd	ltd	PROPN
admet-3	62	24	.	.	PROPN
admet-3	62	25	forest	forest	PROPN
admet-3	62	26	row	row	NOUN
admet-3	62	27	,	,	PUNCT
admet-3	62	28	uk	uk	PROPN
admet-3	62	29	)	)	PUNCT
admet-3	62	30	.	.	PUNCT
admet-3	63	1	titration	titration	NOUN
admet-3	63	2	in	in	ADP
admet-3	63	3	aqueous	aqueous	ADJ
admet-3	63	4	medium	medium	ADJ
admet-3	63	5	six	six	NUM
admet-3	63	6	millilitres	millilitre	NOUN
admet-3	63	7	of	of	ADP
admet-3	63	8	1.97–2.10	1.97–2.10	NUM
admet-3	63	9	mm	mm	PROPN
admet-3	63	10	aqueous	aqueous	ADJ
admet-3	63	11	solutions	solution	NOUN
admet-3	63	12	of	of	ADP
admet-3	63	13	the	the	DET
admet-3	63	14	sample	sample	NOUN
admet-3	63	15	were	be	AUX
admet-3	63	16	preacidified	preacidified	ADJ
admet-3	63	17	to	to	AUX
admet-3	63	18	ph	ph	VERB
admet-3	63	19	1.8	1.8	NUM
admet-3	63	20	with	with	ADP
admet-3	63	21	0.5	0.5	NUM
admet-3	63	22	m	m	NOUN
admet-3	63	23	hcl	hcl	PROPN
admet-3	63	24	and	and	CCONJ
admet-3	63	25	then	then	ADV
admet-3	63	26	titrated	titrate	VERB
admet-3	63	27	alkalimetrically	alkalimetrically	ADV
admet-3	63	28	to	to	ADP
admet-3	63	29	ph	ph	PROPN
admet-3	63	30	12	12	NUM
admet-3	63	31	.	.	PUNCT
admet-3	64	1	the	the	DET
admet-3	64	2	titrations	titration	NOUN
admet-3	64	3	were	be	AUX
admet-3	64	4	carried	carry	VERB
admet-3	64	5	out	out	ADP
admet-3	64	6	at	at	ADP
admet-3	64	7	25.0	25.0	NUM
admet-3	64	8	±	±	NUM
admet-3	64	9	0.1	0.1	NUM
admet-3	64	10	c	c	NUM
admet-3	64	11	,	,	PUNCT
admet-3	64	12	at	at	ADP
admet-3	64	13	0.15	0.15	NUM
admet-3	64	14	m	m	NOUN
admet-3	64	15	ionic	ionic	ADJ
admet-3	64	16	strength	strength	NOUN
admet-3	64	17	using	use	VERB
admet-3	64	18	kcl	kcl	NOUN
admet-3	64	19	under	under	ADP
admet-3	64	20	an	an	DET
admet-3	64	21	n2	n2	ADJ
admet-3	64	22	atmosphere	atmosphere	NOUN
admet-3	64	23	.	.	PUNCT
admet-3	65	1	three	three	NUM
admet-3	65	2	separate	separate	ADJ
admet-3	65	3	titrations	titration	NOUN
admet-3	65	4	were	be	AUX
admet-3	65	5	performed	perform	VERB
admet-3	65	6	.	.	PUNCT
admet-3	66	1	the	the	DET
admet-3	66	2	initial	initial	ADJ
admet-3	66	3	admet	admet	PROPN
admet-3	66	4	&	&	CCONJ
admet-3	66	5	dmpk	dmpk	PROPN
admet-3	66	6	1(2	1(2	NUM
admet-3	66	7	)	)	PUNCT
admet-3	66	8	(	(	PUNCT
admet-3	66	9	2013	2013	NUM
admet-3	66	10	)	)	PUNCT
admet-3	66	11	6	6	NUM
admet-3	66	12	-	-	SYM
admet-3	66	13	16	16	NUM
admet-3	66	14	lisinopril	lisinopril	PROPN
admet-3	66	15	speciation	speciation	NOUN
admet-3	66	16	doi	doi	NOUN
admet-3	66	17	:	:	PUNCT
admet-3	66	18	10.5599	10.5599	NUM
admet-3	66	19	/	/	SYM
admet-3	66	20	admet.1.2.3	admet.1.2.3	NOUN
admet-3	66	21	9	9	NUM
admet-3	66	22	estimates	estimate	NOUN
admet-3	66	23	of	of	ADP
admet-3	66	24	log	log	NOUN
admet-3	66	25	k	k	PROPN
admet-3	66	26	values	value	NOUN
admet-3	66	27	were	be	AUX
admet-3	66	28	obtained	obtain	VERB
admet-3	66	29	from	from	ADP
admet-3	66	30	bjerrum	bjerrum	NOUN
admet-3	66	31	difference	difference	NOUN
admet-3	66	32	plots	plot	NOUN
admet-3	66	33	(	(	PUNCT
admet-3	66	34	n	n	X
admet-3	66	35	vs.	vs.	X
admet-3	66	36	ph	ph	NOUN
admet-3	66	37	,	,	PUNCT
admet-3	66	38	when	when	SCONJ
admet-3	66	39	n	n	PRON
admet-3	66	40	is	be	AUX
admet-3	66	41	the	the	DET
admet-3	66	42	average	average	ADJ
admet-3	66	43	number	number	NOUN
admet-3	66	44	of	of	ADP
admet-3	66	45	bound	bind	VERB
admet-3	66	46	protons	proton	NOUN
admet-3	66	47	)	)	PUNCT
admet-3	66	48	and	and	CCONJ
admet-3	66	49	were	be	AUX
admet-3	66	50	refined	refine	VERB
admet-3	66	51	by	by	ADP
admet-3	66	52	a	a	DET
admet-3	66	53	weighted	weighted	ADJ
admet-3	66	54	non	non	ADJ
admet-3	66	55	-	-	ADJ
admet-3	66	56	linear	linear	ADJ
admet-3	66	57	least	least	ADJ
admet-3	66	58	squares	square	NOUN
admet-3	66	59	procedure	procedure	NOUN
admet-3	66	60	using	use	VERB
admet-3	66	61	refinement	refinement	NOUN
admet-3	66	62	protm	protm	NOUN
admet-3	66	63	2.2	2.2	NUM
admet-3	66	64	software	software	NOUN
admet-3	66	65	(	(	PUNCT
admet-3	66	66	sirius	sirius	PROPN
admet-3	66	67	analytical	analytical	PROPN
admet-3	66	68	instr	instr	PROPN
admet-3	66	69	.	.	PUNCT
admet-3	66	70	ltd	ltd	PROPN
admet-3	66	71	.	.	PROPN
admet-3	66	72	forest	forest	PROPN
admet-3	66	73	row	row	NOUN
admet-3	66	74	,	,	PUNCT
admet-3	66	75	uk	uk	PROPN
admet-3	66	76	)	)	PUNCT
admet-3	66	77	.	.	PUNCT
admet-3	67	1	titration	titration	NOUN
admet-3	67	2	in	in	ADP
admet-3	67	3	solvent	solvent	NOUN
admet-3	67	4	mixtures	mixture	NOUN
admet-3	67	5	three	three	NUM
admet-3	67	6	semi	semi	ADJ
admet-3	67	7	-	-	ADJ
admet-3	67	8	aqueous	aqueous	ADJ
admet-3	67	9	solutions	solution	NOUN
admet-3	67	10	of	of	ADP
admet-3	67	11	lisinopril	lisinopril	NOUN
admet-3	67	12	containing	contain	VERB
admet-3	67	13	14.21	14.21	NUM
admet-3	67	14	,	,	PUNCT
admet-3	67	15	28.54	28.54	NUM
admet-3	67	16	and	and	CCONJ
admet-3	67	17	43.82	43.82	NUM
admet-3	67	18	wt%	wt%	ADJ
admet-3	67	19	methanol	methanol	NOUN
admet-3	67	20	were	be	AUX
admet-3	67	21	titrated	titrate	VERB
admet-3	67	22	under	under	ADP
admet-3	67	23	the	the	DET
admet-3	67	24	same	same	ADJ
admet-3	67	25	experimental	experimental	ADJ
admet-3	67	26	conditions	condition	NOUN
admet-3	67	27	as	as	ADP
admet-3	67	28	in	in	ADP
admet-3	67	29	aqueous	aqueous	ADJ
admet-3	67	30	medium	medium	NOUN
admet-3	67	31	.	.	PUNCT
admet-3	68	1	the	the	DET
admet-3	68	2	apparent	apparent	ADJ
admet-3	68	3	protonation	protonation	NOUN
admet-3	68	4	constants	constant	NOUN
admet-3	68	5	(	(	PUNCT
admet-3	68	6	logs	log	NOUN
admet-3	68	7	k	k	NOUN
admet-3	68	8	)	)	PUNCT
admet-3	68	9	were	be	AUX
admet-3	68	10	calculated	calculate	VERB
admet-3	68	11	from	from	ADP
admet-3	68	12	the	the	DET
admet-3	68	13	difference	difference	NOUN
admet-3	68	14	(	(	PUNCT
admet-3	68	15	bjerrum	bjerrum	NOUN
admet-3	68	16	)	)	PUNCT
admet-3	68	17	plot	plot	NOUN
admet-3	68	18	in	in	ADP
admet-3	68	19	a	a	DET
admet-3	68	20	similar	similar	ADJ
admet-3	68	21	manner	manner	NOUN
admet-3	68	22	as	as	ADP
admet-3	68	23	the	the	DET
admet-3	68	24	aqueous	aqueous	ADJ
admet-3	68	25	log	log	NOUN
admet-3	68	26	k	k	PROPN
admet-3	68	27	values	value	NOUN
admet-3	68	28	.	.	PUNCT
admet-3	69	1	the	the	DET
admet-3	69	2	yasuda	yasuda	NOUN
admet-3	69	3	-	-	PUNCT
admet-3	69	4	shedlovsky	shedlovsky	ADJ
admet-3	69	5	procedure	procedure	NOUN
admet-3	69	6	was	be	AUX
admet-3	69	7	applied	apply	VERB
admet-3	69	8	to	to	PART
admet-3	69	9	estimate	estimate	VERB
admet-3	69	10	the	the	DET
admet-3	69	11	aqueous	aqueous	ADJ
admet-3	69	12	log	log	NOUN
admet-3	69	13	k	k	PROPN
admet-3	69	14	values	value	NOUN
admet-3	69	15	.	.	PUNCT
admet-3	70	1	the	the	DET
admet-3	70	2	yasuda	yasuda	NOUN
admet-3	70	3	-	-	PUNCT
admet-3	70	4	shedlovsky	shedlovsky	ADJ
admet-3	70	5	extrapolation	extrapolation	NOUN
admet-3	70	6	method	method	NOUN
admet-3	70	7	is	be	AUX
admet-3	70	8	based	base	VERB
admet-3	70	9	on	on	ADP
admet-3	70	10	the	the	DET
admet-3	70	11	linear	linear	PROPN
admet-3	70	12	relation	relation	NOUN
admet-3	70	13	between	between	ADP
admet-3	70	14	logs	log	NOUN
admet-3	70	15	k	k	PROPN
admet-3	70	16	and	and	CCONJ
admet-3	70	17	the	the	DET
admet-3	70	18	dielectric	dielectric	ADJ
admet-3	70	19	constant	constant	ADJ
admet-3	70	20	(	(	PUNCT
admet-3	70	21	ε	ε	PROPN
admet-3	70	22	)	)	PUNCT
admet-3	70	23	of	of	ADP
admet-3	70	24	a	a	DET
admet-3	70	25	solvent	solvent	ADJ
admet-3	70	26	mixture	mixture	NOUN
admet-3	70	27	:	:	PUNCT
admet-3	70	28	logs	log	VERB
admet-3	70	29	k	k	PROPN
admet-3	71	1	+	+	CCONJ
admet-3	71	2	log	log	NOUN
admet-3	71	3	[	[	X
admet-3	71	4	h2o	h2o	X
admet-3	71	5	]	]	X
admet-3	71	6	=	=	SYM
admet-3	71	7	a	a	PRON
admet-3	71	8	/	/	SYM
admet-3	71	9	ε	ε	PROPN
admet-3	71	10	+	+	CCONJ
admet-3	71	11	b	b	PROPN
admet-3	71	12	(	(	PUNCT
admet-3	71	13	2	2	NUM
admet-3	71	14	)	)	PUNCT
admet-3	71	15	where	where	SCONJ
admet-3	71	16	a	a	PRON
admet-3	71	17	is	be	AUX
admet-3	71	18	the	the	DET
admet-3	71	19	slope	slope	NOUN
admet-3	71	20	,	,	PUNCT
admet-3	71	21	b	b	PROPN
admet-3	71	22	is	be	AUX
admet-3	71	23	the	the	DET
admet-3	71	24	intercept	intercept	NOUN
admet-3	71	25	(	(	PUNCT
admet-3	71	26	fitting	fit	VERB
admet-3	71	27	constant	constant	ADJ
admet-3	71	28	)	)	PUNCT
admet-3	71	29	of	of	ADP
admet-3	71	30	the	the	DET
admet-3	71	31	linear	linear	PROPN
admet-3	71	32	equation	equation	NOUN
admet-3	71	33	,	,	PUNCT
admet-3	71	34	ε	ε	PROPN
admet-3	71	35	is	be	AUX
admet-3	71	36	the	the	DET
admet-3	71	37	dielectric	dielectric	ADJ
admet-3	71	38	constant	constant	ADJ
admet-3	71	39	of	of	ADP
admet-3	71	40	the	the	DET
admet-3	71	41	methanol	methanol	NOUN
admet-3	71	42	-	-	PUNCT
admet-3	71	43	water	water	NOUN
admet-3	71	44	mixture	mixture	NOUN
admet-3	71	45	and	and	CCONJ
admet-3	71	46	log	log	NOUN
admet-3	71	47	[	[	X
admet-3	71	48	h2o	h2o	X
admet-3	71	49	]	]	PUNCT
admet-3	71	50	is	be	AUX
admet-3	71	51	the	the	DET
admet-3	71	52	molar	molar	ADJ
admet-3	71	53	water	water	NOUN
admet-3	71	54	concentration	concentration	NOUN
admet-3	71	55	of	of	ADP
admet-3	71	56	the	the	DET
admet-3	71	57	given	give	VERB
admet-3	71	58	solvent	solvent	NOUN
admet-3	71	59	mixture	mixture	NOUN
admet-3	71	60	.	.	PUNCT
admet-3	72	1	this	this	DET
admet-3	72	2	method	method	NOUN
admet-3	72	3	is	be	AUX
admet-3	72	4	a	a	DET
admet-3	72	5	widely	widely	ADV
admet-3	72	6	used	use	VERB
admet-3	72	7	procedure	procedure	NOUN
admet-3	72	8	in	in	ADP
admet-3	72	9	co	co	ADJ
admet-3	72	10	-	-	ADJ
admet-3	72	11	solvent	solvent	ADJ
admet-3	72	12	techniques	technique	NOUN
admet-3	72	13	[	[	X
admet-3	72	14	19,20	19,20	X
admet-3	72	15	]	]	PUNCT
admet-3	72	16	.	.	PUNCT
admet-3	73	1	1	1	NUM
admet-3	73	2	h	h	PROPN
admet-3	73	3	nmr	nmr	NOUN
admet-3	73	4	titration	titration	NOUN
admet-3	73	5	with	with	ADP
admet-3	73	6	in	in	ADP
admet-3	73	7	situ	situ	ADJ
admet-3	73	8	ph	ph	NOUN
admet-3	73	9	monitoring	monitoring	NOUN
admet-3	73	10	a	a	DET
admet-3	73	11	single	single	ADJ
admet-3	73	12	nmr	nmr	NOUN
admet-3	73	13	sample	sample	NOUN
admet-3	73	14	solution	solution	NOUN
admet-3	73	15	of	of	ADP
admet-3	73	16	0.6	0.6	NUM
admet-3	73	17	ml	ml	NOUN
admet-3	73	18	was	be	AUX
admet-3	73	19	prepared	prepare	VERB
admet-3	73	20	containing	contain	VERB
admet-3	73	21	8	8	NUM
admet-3	73	22	mm	mm	NUM
admet-3	73	23	lisinopril	lisinopril	NOUN
admet-3	73	24	,	,	PUNCT
admet-3	73	25	140	140	NUM
admet-3	73	26	mm	mm	NOUN
admet-3	73	27	nacl	nacl	NOUN
admet-3	73	28	(	(	PUNCT
admet-3	73	29	to	to	PART
admet-3	73	30	ensure	ensure	VERB
admet-3	73	31	a	a	DET
admet-3	73	32	constant	constant	ADJ
admet-3	73	33	ionic	ionic	ADJ
admet-3	73	34	strength	strength	NOUN
admet-3	73	35	of	of	ADP
admet-3	73	36	0.15	0.15	NUM
admet-3	73	37	m	m	NOUN
admet-3	73	38	)	)	PUNCT
admet-3	73	39	in	in	ADP
admet-3	73	40	a	a	DET
admet-3	73	41	9/1	9/1	NUM
admet-3	73	42	h2o	h2o	PROPN
admet-3	73	43	/	/	SYM
admet-3	73	44	d2o	d2o	NOUN
admet-3	73	45	solvent	solvent	NOUN
admet-3	73	46	mixture	mixture	NOUN
admet-3	73	47	.	.	PUNCT
admet-3	74	1	this	this	DET
admet-3	74	2	sample	sample	NOUN
admet-3	74	3	also	also	ADV
admet-3	74	4	contained	contain	VERB
admet-3	74	5	2	2	NUM
admet-3	74	6	mm	mm	NOUN
admet-3	74	7	of	of	ADP
admet-3	74	8	the	the	DET
admet-3	74	9	following	follow	VERB
admet-3	74	10	ph	ph	ADJ
admet-3	74	11	indicator	indicator	NOUN
admet-3	74	12	molecules	molecule	NOUN
admet-3	74	13	:	:	PUNCT
admet-3	74	14	dichloroacetic	dichloroacetic	ADJ
admet-3	74	15	acid	acid	NOUN
admet-3	74	16	,	,	PUNCT
admet-3	74	17	chloroacetic	chloroacetic	ADJ
admet-3	74	18	acid	acid	NOUN
admet-3	74	19	,	,	PUNCT
admet-3	74	20	acetic	acetic	ADJ
admet-3	74	21	acid	acid	NOUN
admet-3	74	22	,	,	PUNCT
admet-3	74	23	imidazole	imidazole	NOUN
admet-3	74	24	,	,	PUNCT
admet-3	74	25	tris(hydroxymethyl)-aminomethane	tris(hydroxymethyl)-aminomethane	NOUN
admet-3	74	26	(	(	PUNCT
admet-3	74	27	tris	tris	NOUN
admet-3	74	28	)	)	PUNCT
admet-3	74	29	and	and	CCONJ
admet-3	74	30	trimethylamine	trimethylamine	NOUN
admet-3	74	31	hydrochloride	hydrochloride	NOUN
admet-3	74	32	(	(	PUNCT
admet-3	74	33	tma	tma	PROPN
admet-3	74	34	)	)	PUNCT
admet-3	74	35	in	in	ADP
admet-3	74	36	order	order	NOUN
admet-3	74	37	to	to	PART
admet-3	74	38	determine	determine	VERB
admet-3	74	39	the	the	DET
admet-3	74	40	actual	actual	ADJ
admet-3	74	41	ph	ph	NOUN
admet-3	74	42	of	of	ADP
admet-3	74	43	the	the	DET
admet-3	74	44	sample	sample	NOUN
admet-3	74	45	in	in	ADP
admet-3	74	46	each	each	DET
admet-3	74	47	titration	titration	NOUN
admet-3	74	48	step	step	NOUN
admet-3	74	49	,	,	PUNCT
admet-3	74	50	according	accord	VERB
admet-3	74	51	to	to	ADP
admet-3	74	52	the	the	DET
admet-3	74	53	electrodeless	electrodeless	ADJ
admet-3	74	54	single	single	ADJ
admet-3	74	55	tube	tube	NOUN
admet-3	74	56	nmr	nmr	NOUN
admet-3	74	57	titration	titration	NOUN
admet-3	74	58	method	method	NOUN
admet-3	74	59	[	[	X
admet-3	74	60	21	21	NUM
admet-3	74	61	]	]	PUNCT
admet-3	74	62	.	.	PUNCT
admet-3	75	1	as	as	ADP
admet-3	75	2	an	an	DET
admet-3	75	3	internal	internal	ADJ
admet-3	75	4	chemical	chemical	NOUN
admet-3	75	5	shift	shift	NOUN
admet-3	75	6	reference	reference	NOUN
admet-3	75	7	,	,	PUNCT
admet-3	75	8	0.5	0.5	NUM
admet-3	75	9	mm	mm	NOUN
admet-3	75	10	of	of	ADP
admet-3	75	11	sodium	sodium	NOUN
admet-3	75	12	3-(trimethylsilyl)-1propanesulfonate	3-(trimethylsilyl)-1propanesulfonate	NOUN
admet-3	75	13	(	(	PUNCT
admet-3	75	14	dss	dss	NOUN
admet-3	75	15	)	)	PUNCT
admet-3	75	16	was	be	AUX
admet-3	75	17	applied	apply	VERB
admet-3	75	18	.	.	PUNCT
admet-3	76	1	the	the	DET
admet-3	76	2	1h	1h	NUM
admet-3	76	3	nmr	nmr	NOUN
admet-3	76	4	spectra	spectra	NOUN
admet-3	76	5	were	be	AUX
admet-3	76	6	recorded	record	VERB
admet-3	76	7	at	at	ADP
admet-3	76	8	25.0	25.0	NUM
admet-3	76	9			PROPN
admet-3	76	10	0.1	0.1	NUM
admet-3	76	11	c	c	NOUN
admet-3	76	12	.	.	PUNCT
admet-3	77	1	the	the	DET
admet-3	77	2	water	water	NOUN
admet-3	77	3	signal	signal	NOUN
admet-3	77	4	was	be	AUX
admet-3	77	5	suppressed	suppress	VERB
admet-3	77	6	either	either	CCONJ
admet-3	77	7	by	by	ADP
admet-3	77	8	the	the	DET
admet-3	77	9	double	double	ADJ
admet-3	77	10	pulse	pulse	NOUN
admet-3	77	11	field	field	NOUN
admet-3	77	12	gradient	gradient	NOUN
admet-3	77	13	spin	spin	NOUN
admet-3	77	14	echo	echo	NOUN
admet-3	77	15	(	(	PUNCT
admet-3	77	16	dpfgse	dpfgse	ADJ
admet-3	77	17	)	)	PUNCT
admet-3	77	18	or	or	CCONJ
admet-3	77	19	the	the	DET
admet-3	77	20	selective	selective	ADJ
admet-3	77	21	presaturation	presaturation	NOUN
admet-3	77	22	(	(	PUNCT
admet-3	77	23	presat	presat	NOUN
admet-3	77	24	)	)	PUNCT
admet-3	77	25	sequence	sequence	NOUN
admet-3	77	26	.	.	PUNCT
admet-3	78	1	the	the	PRON
admet-3	78	2	in	in	ADP
admet-3	78	3	situ	situ	ADJ
admet-3	78	4	ph	ph	NOUN
admet-3	78	5	value	value	NOUN
admet-3	78	6	was	be	AUX
admet-3	78	7	deduced	deduce	VERB
admet-3	78	8	from	from	ADP
admet-3	78	9	the	the	DET
admet-3	78	10	chemical	chemical	NOUN
admet-3	78	11	shift	shift	NOUN
admet-3	78	12	of	of	ADP
admet-3	78	13	the	the	DET
admet-3	78	14	appropriate	appropriate	ADJ
admet-3	78	15	indicator	indicator	NOUN
admet-3	78	16	by	by	ADP
admet-3	78	17	the	the	DET
admet-3	78	18	following	follow	VERB
admet-3	78	19	equation	equation	NOUN
admet-3	78	20	:	:	PUNCT
admet-3	78	21	obs	obs	PROPN
admet-3	78	22	indind	indind	PROPN
admet-3	78	23	hind	hind	PROPN
admet-3	78	24	obs	obs	PROPN
admet-3	78	25	ind	ind	PROPN
admet-3	78	26	ind	ind	PROPN
admet-3	78	27	loglogph	loglogph	NOUN
admet-3	78	28	δδ	δδ	ADP
admet-3	78	29	δδ	δδ	ADP
admet-3	78	30	k	k	PROPN
admet-3	78	31			PROPN
admet-3	78	32			PROPN
admet-3	78	33			PROPN
admet-3	78	34	(	(	PUNCT
admet-3	78	35	3	3	NUM
admet-3	78	36	)	)	PUNCT
admet-3	78	37	where	where	SCONJ
admet-3	78	38	log	log	NOUN
admet-3	78	39	kind	kind	NOUN
admet-3	78	40	is	be	AUX
admet-3	78	41	the	the	DET
admet-3	78	42	protonation	protonation	NOUN
admet-3	78	43	constant	constant	ADJ
admet-3	78	44	of	of	ADP
admet-3	78	45	the	the	DET
admet-3	78	46	indicator	indicator	NOUN
admet-3	78	47	and	and	CCONJ
admet-3	78	48	ind	ind	ADJ
admet-3	78	49	,	,	PUNCT
admet-3	78	50	hind	hind	NOUN
admet-3	78	51	are	be	AUX
admet-3	78	52	the	the	DET
admet-3	78	53	limiting	limit	VERB
admet-3	78	54	chemical	chemical	ADJ
admet-3	78	55	shifts	shift	NOUN
admet-3	78	56	of	of	ADP
admet-3	78	57	its	its	PRON
admet-3	78	58	non	non	ADJ
admet-3	78	59	-	-	ADJ
admet-3	78	60	protonated	protonated	ADJ
admet-3	78	61	and	and	CCONJ
admet-3	78	62	protonated	protonated	ADJ
admet-3	78	63	forms	form	NOUN
admet-3	78	64	(	(	PUNCT
admet-3	78	65	determined	determine	VERB
admet-3	78	66	in	in	ADP
admet-3	78	67	separate	separate	ADJ
admet-3	78	68	experiments	experiment	NOUN
admet-3	78	69	)	)	PUNCT
admet-3	79	1	[	[	X
admet-3	79	2	22,23	22,23	NOUN
admet-3	79	3	]	]	X
admet-3	79	4	.	.	PUNCT
admet-3	80	1	the	the	DET
admet-3	80	2	nmr	nmr	NOUN
admet-3	80	3	-	-	PUNCT
admet-3	80	4	ph	ph	ADJ
admet-3	80	5	datasets	dataset	NOUN
admet-3	80	6	were	be	AUX
admet-3	80	7	fitted	fit	VERB
admet-3	80	8	with	with	ADP
admet-3	80	9	the	the	DET
admet-3	80	10	opium	opium	NOUN
admet-3	80	11	computer	computer	NOUN
admet-3	80	12	program	program	NOUN
admet-3	80	13	[	[	X
admet-3	80	14	24	24	NUM
admet-3	80	15	]	]	PUNCT
admet-3	80	16	to	to	PART
admet-3	80	17	determine	determine	VERB
admet-3	80	18	protonation	protonation	NOUN
admet-3	80	19	macroconstants	macroconstant	NOUN
admet-3	80	20	and	and	CCONJ
admet-3	80	21	chemical	chemical	NOUN
admet-3	80	22	shift	shift	NOUN
admet-3	80	23	values	value	NOUN
admet-3	80	24	specific	specific	ADJ
admet-3	80	25	to	to	ADP
admet-3	80	26	each	each	DET
admet-3	80	27	macrospecies	macrospecie	NOUN
admet-3	80	28	(	(	PUNCT
admet-3	80	29	dhilis	dhili	NOUN
admet-3	80	30	)	)	PUNCT
admet-3	80	31	.	.	PUNCT
admet-3	81	1	results	result	NOUN
admet-3	81	2	and	and	CCONJ
admet-3	81	3	discussion	discussion	NOUN
admet-3	81	4	among	among	ADP
admet-3	81	5	the	the	DET
admet-3	81	6	ace	ace	NOUN
admet-3	81	7	inhibitor	inhibitor	NOUN
admet-3	81	8	drugs	drug	NOUN
admet-3	81	9	,	,	PUNCT
admet-3	81	10	lisinopril	lisinopril	PROPN
admet-3	81	11	has	have	VERB
admet-3	81	12	the	the	DET
admet-3	81	13	most	most	ADV
admet-3	81	14	interesting	interesting	ADJ
admet-3	81	15	and	and	CCONJ
admet-3	81	16	complex	complex	ADJ
admet-3	81	17	acid	acid	NOUN
admet-3	81	18	-	-	PUNCT
admet-3	81	19	base	base	NOUN
admet-3	81	20	chemistry	chemistry	NOUN
admet-3	81	21	.	.	PUNCT
admet-3	82	1	there	there	PRON
admet-3	82	2	are	be	VERB
admet-3	82	3	four	four	NUM
admet-3	82	4	proton	proton	NOUN
admet-3	82	5	-	-	PUNCT
admet-3	82	6	binding	bind	VERB
admet-3	82	7	sites	site	NOUN
admet-3	82	8	in	in	ADP
admet-3	82	9	the	the	DET
admet-3	82	10	molecule	molecule	NOUN
admet-3	82	11	:	:	PUNCT
admet-3	82	12	two	two	NUM
admet-3	82	13	carboxylates	carboxylate	NOUN
admet-3	82	14	as	as	ADV
admet-3	82	15	well	well	ADV
admet-3	82	16	as	as	ADP
admet-3	82	17	a	a	DET
admet-3	82	18	primary	primary	NOUN
admet-3	82	19	and	and	CCONJ
admet-3	82	20	a	a	DET
admet-3	82	21	secondary	secondary	ADJ
admet-3	82	22	krisztina	krisztina	NOUN
admet-3	83	1	takács	takács	PROPN
admet-3	83	2	novák	novák	PROPN
admet-3	83	3	et	et	PROPN
admet-3	83	4	al	al	PROPN
admet-3	83	5	.	.	PROPN
admet-3	83	6	admet	admet	PROPN
admet-3	83	7	&	&	CCONJ
admet-3	83	8	dmpk	dmpk	PROPN
admet-3	83	9	1(2	1(2	NUM
admet-3	83	10	)	)	PUNCT
admet-3	83	11	(	(	PUNCT
admet-3	83	12	2013	2013	NUM
admet-3	83	13	)	)	PUNCT
admet-3	83	14	6	6	NUM
admet-3	83	15	-	-	SYM
admet-3	83	16	16	16	NUM
admet-3	83	17	10	10	NUM
admet-3	83	18	amine	amine	ADJ
admet-3	83	19	group	group	NOUN
admet-3	83	20	.	.	PUNCT
admet-3	84	1	the	the	DET
admet-3	84	2	protonation	protonation	NOUN
admet-3	84	3	processes	process	NOUN
admet-3	84	4	of	of	ADP
admet-3	84	5	the	the	DET
admet-3	84	6	two	two	NUM
admet-3	84	7	carboxylate	carboxylate	NOUN
admet-3	84	8	groups	group	NOUN
admet-3	84	9	are	be	AUX
admet-3	84	10	expected	expect	VERB
admet-3	84	11	to	to	PART
admet-3	84	12	be	be	AUX
admet-3	84	13	highly	highly	ADV
admet-3	84	14	overlapping	overlapping	ADJ
admet-3	84	15	.	.	PUNCT
admet-3	85	1	for	for	ADP
admet-3	85	2	the	the	DET
admet-3	85	3	investigation	investigation	NOUN
admet-3	85	4	of	of	ADP
admet-3	85	5	the	the	DET
admet-3	85	6	ionisation	ionisation	NOUN
admet-3	85	7	/	/	SYM
admet-3	85	8	protonation	protonation	NOUN
admet-3	85	9	properties	property	NOUN
admet-3	85	10	of	of	ADP
admet-3	85	11	the	the	DET
admet-3	85	12	molecule	molecule	NOUN
admet-3	85	13	,	,	PUNCT
admet-3	85	14	potentiometry	potentiometry	NOUN
admet-3	85	15	in	in	ADP
admet-3	85	16	aqueous	aqueous	ADJ
admet-3	85	17	medium	medium	NOUN
admet-3	85	18	and	and	CCONJ
admet-3	85	19	in	in	ADP
admet-3	85	20	methanol	methanol	NOUN
admet-3	85	21	-	-	PUNCT
admet-3	85	22	water	water	NOUN
admet-3	85	23	mixtures	mixture	NOUN
admet-3	85	24	as	as	ADV
admet-3	85	25	well	well	ADV
admet-3	85	26	as	as	ADP
admet-3	85	27	nmr	nmr	NOUN
admet-3	85	28	-	-	PUNCT
admet-3	85	29	ph	ph	NOUN
admet-3	85	30	titration	titration	NOUN
admet-3	85	31	were	be	AUX
admet-3	85	32	applied	apply	VERB
admet-3	85	33	.	.	PUNCT
admet-3	86	1	protonation	protonation	NOUN
admet-3	86	2	macroconstants	macroconstant	VERB
admet-3	86	3	the	the	DET
admet-3	86	4	stepwise	stepwise	ADJ
admet-3	86	5	protonation	protonation	NOUN
admet-3	86	6	equilibria	equilibrium	NOUN
admet-3	86	7	(	(	PUNCT
admet-3	86	8	fig	fig	NOUN
admet-3	86	9	.	.	NOUN
admet-3	87	1	2	2	NUM
admet-3	87	2	)	)	PUNCT
admet-3	87	3	of	of	ADP
admet-3	87	4	the	the	DET
admet-3	87	5	whole	whole	ADJ
admet-3	87	6	molecule	molecule	NOUN
admet-3	87	7	are	be	AUX
admet-3	87	8	characterised	characterise	VERB
admet-3	87	9	in	in	ADP
admet-3	87	10	terms	term	NOUN
admet-3	87	11	of	of	ADP
admet-3	87	12	protonation	protonation	NOUN
admet-3	87	13	macroconstants	macroconstant	NOUN
admet-3	87	14	,	,	PUNCT
admet-3	87	15	log	log	VERB
admet-3	87	16	k	k	PROPN
admet-3	87	17	values	value	NOUN
admet-3	87	18	.	.	PUNCT
admet-3	88	1	figure	figure	NOUN
admet-3	88	2	2	2	NUM
admet-3	88	3	.	.	PUNCT
admet-3	88	4	stepwise	stepwise	ADJ
admet-3	88	5	protonation	protonation	NOUN
admet-3	88	6	equilibria	equilibrium	NOUN
admet-3	88	7	of	of	ADP
admet-3	88	8	lisinopril	lisinopril	NOUN
admet-3	88	9	generally	generally	ADV
admet-3	88	10	,	,	PUNCT
admet-3	88	11	potentiometry	potentiometry	NOUN
admet-3	88	12	in	in	ADP
admet-3	88	13	aqueous	aqueous	ADJ
admet-3	88	14	medium	medium	NOUN
admet-3	88	15	is	be	AUX
admet-3	88	16	the	the	DET
admet-3	88	17	method	method	NOUN
admet-3	88	18	of	of	ADP
admet-3	88	19	choice	choice	NOUN
admet-3	88	20	for	for	ADP
admet-3	88	21	logk	logk	ADJ
admet-3	88	22	determination	determination	NOUN
admet-3	88	23	for	for	ADP
admet-3	88	24	molecules	molecule	NOUN
admet-3	88	25	with	with	ADP
admet-3	88	26	solubility	solubility	NOUN
admet-3	88	27	greater	great	ADJ
admet-3	88	28	than	than	ADP
admet-3	88	29	0.8	0.8	NUM
admet-3	88	30	mm	mm	NOUN
admet-3	88	31	in	in	ADP
admet-3	88	32	the	the	DET
admet-3	88	33	entire	entire	ADJ
admet-3	88	34	ph	ph	ADJ
admet-3	88	35	interval	interval	NOUN
admet-3	88	36	of	of	ADP
admet-3	88	37	interest	interest	NOUN
admet-3	88	38	.	.	PUNCT
admet-3	89	1	the	the	DET
admet-3	89	2	solubility	solubility	NOUN
admet-3	89	3	of	of	ADP
admet-3	89	4	lisinopril	lisinopril	NOUN
admet-3	89	5	(	(	PUNCT
admet-3	89	6	0.22	0.22	NUM
admet-3	89	7	m	m	NOUN
admet-3	89	8	,	,	PUNCT
admet-3	89	9	[	[	X
admet-3	89	10	9	9	NUM
admet-3	89	11	]	]	PUNCT
admet-3	89	12	)	)	PUNCT
admet-3	89	13	allows	allow	VERB
admet-3	89	14	the	the	DET
admet-3	89	15	determination	determination	NOUN
admet-3	89	16	of	of	ADP
admet-3	89	17	macroconstants	macroconstant	NOUN
admet-3	89	18	by	by	ADP
admet-3	89	19	the	the	DET
admet-3	89	20	standard	standard	ADJ
admet-3	89	21	method	method	NOUN
admet-3	89	22	.	.	PUNCT
admet-3	90	1	the	the	DET
admet-3	90	2	four	four	NUM
admet-3	90	3	obtained	obtain	VERB
admet-3	90	4	log	log	NOUN
admet-3	90	5	k	k	PROPN
admet-3	90	6	values	value	NOUN
admet-3	90	7	along	along	ADP
admet-3	90	8	with	with	ADP
admet-3	90	9	the	the	DET
admet-3	90	10	standard	standard	ADJ
admet-3	90	11	deviations	deviation	NOUN
admet-3	90	12	calculated	calculate	VERB
admet-3	90	13	from	from	ADP
admet-3	90	14	three	three	NUM
admet-3	90	15	parallel	parallel	ADJ
admet-3	90	16	titrations	titration	NOUN
admet-3	90	17	(	(	PUNCT
admet-3	90	18	3	3	NUM
admet-3	90	19	x	x	SYM
admet-3	90	20	15	15	NUM
admet-3	90	21	points	point	NOUN
admet-3	90	22	)	)	PUNCT
admet-3	90	23	are	be	AUX
admet-3	90	24	listed	list	VERB
admet-3	90	25	in	in	ADP
admet-3	90	26	table	table	NOUN
admet-3	90	27	1	1	NUM
admet-3	90	28	.	.	PUNCT
admet-3	91	1	since	since	SCONJ
admet-3	91	2	the	the	DET
admet-3	91	3	log	log	NOUN
admet-3	91	4	k4	k4	NOUN
admet-3	91	5	value	value	NOUN
admet-3	91	6	falls	fall	VERB
admet-3	91	7	below	below	ADV
admet-3	91	8	to	to	ADP
admet-3	91	9	the	the	DET
admet-3	91	10	lower	low	ADJ
admet-3	91	11	applicability	applicability	NOUN
admet-3	91	12	limit	limit	NOUN
admet-3	91	13	(	(	PUNCT
admet-3	91	14	log	log	NOUN
admet-3	91	15	k	k	X
admet-3	91	16	<	<	X
admet-3	91	17	2	2	NUM
admet-3	91	18	)	)	PUNCT
admet-3	91	19	of	of	ADP
admet-3	91	20	ph	ph	ADJ
admet-3	91	21	-	-	ADJ
admet-3	91	22	metric	metric	ADJ
admet-3	91	23	titration	titration	NOUN
admet-3	91	24	,	,	PUNCT
admet-3	91	25	we	we	PRON
admet-3	91	26	also	also	ADV
admet-3	91	27	measured	measure	VERB
admet-3	91	28	the	the	DET
admet-3	91	29	protonation	protonation	NOUN
admet-3	91	30	macroconstants	macroconstant	NOUN
admet-3	91	31	using	use	VERB
admet-3	91	32	the	the	DET
admet-3	91	33	co	co	ADJ
admet-3	91	34	-	-	ADJ
admet-3	91	35	solvent	solvent	ADJ
admet-3	91	36	method	method	NOUN
admet-3	91	37	.	.	PUNCT
admet-3	92	1	the	the	DET
admet-3	92	2	effect	effect	NOUN
admet-3	92	3	of	of	ADP
admet-3	92	4	methanol	methanol	NOUN
admet-3	92	5	on	on	ADP
admet-3	92	6	the	the	DET
admet-3	92	7	protonation	protonation	NOUN
admet-3	92	8	constant	constant	ADJ
admet-3	92	9	is	be	AUX
admet-3	92	10	known	know	VERB
admet-3	92	11	to	to	PART
admet-3	92	12	depend	depend	VERB
admet-3	92	13	on	on	ADP
admet-3	92	14	the	the	DET
admet-3	92	15	charge	charge	NOUN
admet-3	92	16	of	of	ADP
admet-3	92	17	the	the	DET
admet-3	92	18	basic	basic	ADJ
admet-3	92	19	site	site	NOUN
admet-3	92	20	.	.	PUNCT
admet-3	93	1	for	for	ADP
admet-3	93	2	acids	acid	NOUN
admet-3	93	3	,	,	PUNCT
admet-3	93	4	the	the	DET
admet-3	93	5	apparent	apparent	ADJ
admet-3	93	6	logs	log	NOUN
admet-3	93	7	k	k	NOUN
admet-3	93	8	value	value	NOUN
admet-3	93	9	increases	increase	VERB
admet-3	93	10	with	with	ADP
admet-3	93	11	the	the	DET
admet-3	93	12	increasing	increase	VERB
admet-3	93	13	weight	weight	NOUN
admet-3	93	14	percent	percent	NOUN
admet-3	93	15	of	of	ADP
admet-3	93	16	methanol	methanol	NOUN
admet-3	93	17	,	,	PUNCT
admet-3	93	18	while	while	SCONJ
admet-3	93	19	a	a	DET
admet-3	93	20	decrease	decrease	NOUN
admet-3	93	21	is	be	AUX
admet-3	93	22	usually	usually	ADV
admet-3	93	23	observed	observe	VERB
admet-3	93	24	for	for	ADP
admet-3	93	25	bases	basis	NOUN
admet-3	93	26	[	[	X
admet-3	93	27	25	25	NUM
admet-3	93	28	]	]	PUNCT
admet-3	93	29	.	.	PUNCT
admet-3	94	1	using	use	VERB
admet-3	94	2	this	this	DET
admet-3	94	3	co	co	ADJ
admet-3	94	4	-	-	ADJ
admet-3	94	5	solvent	solvent	ADJ
admet-3	94	6	method	method	NOUN
admet-3	94	7	,	,	PUNCT
admet-3	94	8	we	we	PRON
admet-3	94	9	obtained	obtain	VERB
admet-3	94	10	a	a	DET
admet-3	94	11	more	more	ADV
admet-3	94	12	reliable	reliable	ADJ
admet-3	94	13	value	value	NOUN
admet-3	94	14	for	for	ADP
admet-3	94	15	logk4	logk4	NOUN
admet-3	94	16	since	since	SCONJ
admet-3	94	17	the	the	DET
admet-3	94	18	logs	log	NOUN
admet-3	94	19	k4	k4	ADJ
admet-3	94	20	values	value	NOUN
admet-3	94	21	in	in	ADP
admet-3	94	22	methanol	methanol	NOUN
admet-3	94	23	-	-	PUNCT
admet-3	94	24	water	water	NOUN
admet-3	94	25	mixtures	mixture	NOUN
admet-3	94	26	shifted	shift	VERB
admet-3	94	27	up	up	ADP
admet-3	94	28	to	to	ADP
admet-3	94	29	the	the	DET
admet-3	94	30	measurable	measurable	ADJ
admet-3	94	31	ph	ph	ADJ
admet-3	94	32	range	range	NOUN
admet-3	94	33	.	.	PUNCT
admet-3	95	1	at	at	ADP
admet-3	95	2	the	the	DET
admet-3	95	3	same	same	ADJ
admet-3	95	4	time	time	NOUN
admet-3	95	5	,	,	PUNCT
admet-3	95	6	this	this	DET
admet-3	95	7	cosolvent	cosolvent	ADJ
admet-3	95	8	method	method	NOUN
admet-3	95	9	allows	allow	VERB
admet-3	95	10	for	for	ADP
admet-3	95	11	assigning	assign	VERB
admet-3	95	12	logk	logk	ADJ
admet-3	95	13	values	value	NOUN
admet-3	95	14	to	to	ADP
admet-3	95	15	the	the	DET
admet-3	95	16	acidic	acidic	ADJ
admet-3	95	17	and	and	CCONJ
admet-3	95	18	basic	basic	ADJ
admet-3	95	19	moieties	moiety	NOUN
admet-3	95	20	of	of	ADP
admet-3	95	21	the	the	DET
admet-3	95	22	molecule	molecule	NOUN
admet-3	95	23	.	.	PUNCT
admet-3	96	1	according	accord	VERB
admet-3	96	2	to	to	ADP
admet-3	96	3	the	the	DET
admet-3	96	4	slopes	slope	NOUN
admet-3	96	5	of	of	ADP
admet-3	96	6	the	the	DET
admet-3	96	7	regression	regression	NOUN
admet-3	96	8	lines	line	NOUN
admet-3	96	9	on	on	ADP
admet-3	96	10	the	the	DET
admet-3	96	11	yasuda	yasuda	NOUN
admet-3	96	12	-	-	PUNCT
admet-3	96	13	shedlovsky	shedlovsky	ADJ
admet-3	96	14	plot	plot	NOUN
admet-3	96	15	(	(	PUNCT
admet-3	96	16	fig	fig	NOUN
admet-3	96	17	.	.	PUNCT
admet-3	96	18	3	3	NUM
admet-3	96	19	)	)	PUNCT
admet-3	96	20	,	,	PUNCT
admet-3	96	21	log	log	VERB
admet-3	96	22	k1	k1	NOUN
admet-3	96	23	and	and	CCONJ
admet-3	96	24	log	log	VERB
admet-3	96	25	k2	k2	PROPN
admet-3	96	26	characterise	characterise	NOUN
admet-3	96	27	amine	amine	ADJ
admet-3	96	28	functions	function	NOUN
admet-3	96	29	,	,	PUNCT
admet-3	96	30	while	while	SCONJ
admet-3	96	31	log	log	NOUN
admet-3	96	32	k3	k3	VERB
admet-3	96	33	and	and	CCONJ
admet-3	96	34	log	log	VERB
admet-3	96	35	k4	k4	VERB
admet-3	96	36	the	the	DET
admet-3	96	37	carboxylate	carboxylate	NOUN
admet-3	96	38	groups	group	NOUN
admet-3	96	39	of	of	ADP
admet-3	96	40	the	the	DET
admet-3	96	41	molecule	molecule	NOUN
admet-3	96	42	,	,	PUNCT
admet-3	96	43	respectively	respectively	ADV
admet-3	96	44	.	.	PUNCT
admet-3	97	1	for	for	ADP
admet-3	97	2	the	the	DET
admet-3	97	3	exact	exact	ADJ
admet-3	97	4	proton	proton	NOUN
admet-3	97	5	speciation	speciation	NOUN
admet-3	97	6	of	of	ADP
admet-3	97	7	lisinopril	lisinopril	PROPN
admet-3	97	8	,	,	PUNCT
admet-3	97	9	1h	1h	NUM
admet-3	97	10	nmr	nmr	NOUN
admet-3	97	11	-	-	PUNCT
admet-3	97	12	ph	ph	ADJ
admet-3	97	13	titrations	titration	NOUN
admet-3	97	14	were	be	AUX
admet-3	97	15	carried	carry	VERB
admet-3	97	16	out	out	ADP
admet-3	97	17	using	use	VERB
admet-3	97	18	the	the	DET
admet-3	97	19	most	most	ADV
admet-3	97	20	similar	similar	ADJ
admet-3	97	21	possible	possible	ADJ
admet-3	97	22	experimental	experimental	ADJ
admet-3	97	23	conditions	condition	NOUN
admet-3	97	24	as	as	ADP
admet-3	97	25	in	in	ADP
admet-3	97	26	potentiometry	potentiometry	NOUN
admet-3	97	27	.	.	PUNCT
admet-3	98	1	fig	fig	NOUN
admet-3	98	2	.	.	PUNCT
admet-3	99	1	4	4	NUM
admet-3	99	2	shows	show	VERB
admet-3	99	3	the	the	DET
admet-3	99	4	aliphatic	aliphatic	ADJ
admet-3	99	5	part	part	NOUN
admet-3	99	6	of	of	ADP
admet-3	99	7	one	one	NUM
admet-3	99	8	spectrum	spectrum	NOUN
admet-3	99	9	from	from	ADP
admet-3	99	10	the	the	DET
admet-3	99	11	titration	titration	NOUN
admet-3	99	12	series	series	NOUN
admet-3	99	13	.	.	PUNCT
admet-3	100	1	admet	admet	PROPN
admet-3	100	2	&	&	CCONJ
admet-3	100	3	dmpk	dmpk	PROPN
admet-3	100	4	1(2	1(2	NUM
admet-3	100	5	)	)	PUNCT
admet-3	100	6	(	(	PUNCT
admet-3	100	7	2013	2013	NUM
admet-3	100	8	)	)	PUNCT
admet-3	100	9	6	6	NUM
admet-3	100	10	-	-	SYM
admet-3	100	11	16	16	NUM
admet-3	100	12	lisinopril	lisinopril	PROPN
admet-3	100	13	speciation	speciation	NOUN
admet-3	100	14	doi	doi	NOUN
admet-3	100	15	:	:	PUNCT
admet-3	100	16	10.5599	10.5599	NUM
admet-3	100	17	/	/	SYM
admet-3	100	18	admet.1.2.3	admet.1.2.3	NOUN
admet-3	100	19	11	11	NUM
admet-3	100	20	figure	figure	NOUN
admet-3	100	21	3	3	NUM
admet-3	100	22	.	.	PUNCT
admet-3	101	1	yasuda	yasuda	PROPN
admet-3	101	2	-	-	PUNCT
admet-3	101	3	shedlovsky	shedlovsky	ADJ
admet-3	101	4	plot	plot	NOUN
admet-3	101	5	where	where	SCONJ
admet-3	101	6	open	open	ADJ
admet-3	101	7	diamonds	diamond	NOUN
admet-3	101	8	denote	denote	VERB
admet-3	101	9	logs	log	NOUN
admet-3	101	10	k1	k1	NOUN
admet-3	101	11	(	(	PUNCT
admet-3	101	12	slope	slope	NOUN
admet-3	101	13	:	:	PUNCT
admet-3	101	14	-138.4	-138.4	NOUN
admet-3	101	15	,	,	PUNCT
admet-3	101	16	intercept	intercept	NOUN
admet-3	101	17	:	:	PUNCT
admet-3	101	18	14.271	14.271	NUM
admet-3	101	19	)	)	PUNCT
admet-3	101	20	,	,	PUNCT
admet-3	101	21	open	open	ADJ
admet-3	101	22	squares	square	NOUN
admet-3	101	23	denote	denote	VERB
admet-3	101	24	logs	log	NOUN
admet-3	101	25	k2	k2	NOUN
admet-3	101	26	(	(	PUNCT
admet-3	101	27	slope	slope	NOUN
admet-3	101	28	:	:	PUNCT
admet-3	101	29	-44.6	-44.6	NOUN
admet-3	101	30	,	,	PUNCT
admet-3	101	31	intercept	intercept	NOUN
admet-3	101	32	:	:	PUNCT
admet-3	101	33	9.532	9.532	NUM
admet-3	101	34	)	)	PUNCT
admet-3	101	35	,	,	PUNCT
admet-3	101	36	filled	fill	VERB
admet-3	101	37	diamonds	diamond	NOUN
admet-3	101	38	denote	denote	VERB
admet-3	101	39	logs	log	NOUN
admet-3	101	40	k3	k3	ADJ
admet-3	101	41	(	(	PUNCT
admet-3	101	42	slope	slope	NOUN
admet-3	101	43	:	:	PUNCT
admet-3	101	44	82.6	82.6	NUM
admet-3	101	45	,	,	PUNCT
admet-3	101	46	intercept	intercept	NOUN
admet-3	101	47	:	:	PUNCT
admet-3	101	48	3.891	3.891	NUM
admet-3	101	49	)	)	PUNCT
admet-3	101	50	and	and	CCONJ
admet-3	101	51	filled	fill	VERB
admet-3	101	52	squares	square	NOUN
admet-3	101	53	denote	denote	VERB
admet-3	101	54	logs	log	NOUN
admet-3	101	55	k4	k4	NOUN
admet-3	101	56	(	(	PUNCT
admet-3	101	57	slope	slope	NOUN
admet-3	101	58	:	:	PUNCT
admet-3	101	59	29.9	29.9	NUM
admet-3	101	60	,	,	PUNCT
admet-3	101	61	intercept	intercept	NOUN
admet-3	101	62	:	:	PUNCT
admet-3	101	63	2.976	2.976	NUM
admet-3	101	64	)	)	PUNCT
admet-3	101	65	.	.	PUNCT
admet-3	102	1	figure	figure	VERB
admet-3	102	2	4	4	NUM
admet-3	102	3	.	.	PUNCT
admet-3	102	4	representative	representative	ADJ
admet-3	102	5	1	1	NUM
admet-3	102	6	h	h	NOUN
admet-3	102	7	nmr	nmr	NOUN
admet-3	102	8	spectrum	spectrum	NOUN
admet-3	102	9	of	of	ADP
admet-3	102	10	lisinopril	lisinopril	NOUN
admet-3	102	11	at	at	ADP
admet-3	102	12	ph	ph	PROPN
admet-3	102	13	5.07	5.07	NUM
admet-3	102	14	in	in	ADP
admet-3	102	15	9/1	9/1	NUM
admet-3	102	16	h2o	h2o	PROPN
admet-3	102	17	/	/	SYM
admet-3	102	18	d2o	d2o	NOUN
admet-3	102	19	.	.	PUNCT
admet-3	103	1	the	the	DET
admet-3	103	2	assignment	assignment	NOUN
admet-3	103	3	is	be	AUX
admet-3	103	4	based	base	VERB
admet-3	103	5	on	on	ADP
admet-3	103	6	conventional	conventional	ADJ
admet-3	103	7	2d	2d	NUM
admet-3	103	8	nmr	nmr	NOUN
admet-3	103	9	techniques	technique	NOUN
admet-3	103	10	.	.	PUNCT
admet-3	104	1	at	at	ADP
admet-3	104	2	certain	certain	ADJ
admet-3	104	3	ph	ph	ADJ
admet-3	104	4	values	value	NOUN
admet-3	104	5	,	,	PUNCT
admet-3	104	6	the	the	DET
admet-3	104	7	assignment	assignment	NOUN
admet-3	104	8	of	of	ADP
admet-3	104	9	overlapping	overlap	VERB
admet-3	104	10	multiplets	multiplet	NOUN
admet-3	104	11	to	to	ADP
admet-3	104	12	methylene	methylene	NOUN
admet-3	104	13	and	and	CCONJ
admet-3	104	14	methine	methine	ADJ
admet-3	104	15	protons	proton	NOUN
admet-3	104	16	was	be	AUX
admet-3	104	17	verified	verify	VERB
admet-3	104	18	by	by	ADP
admet-3	104	19	tocsy	tocsy	PROPN
admet-3	104	20	and	and	CCONJ
admet-3	104	21	hsqc	hsqc	NOUN
admet-3	104	22	experiments	experiment	NOUN
admet-3	104	23	.	.	PUNCT
admet-3	105	1	in	in	ADP
admet-3	105	2	fig	fig	NOUN
admet-3	105	3	.	.	PUNCT
admet-3	106	1	5	5	NUM
admet-3	106	2	,	,	PUNCT
admet-3	106	3	the	the	DET
admet-3	106	4	chemical	chemical	ADJ
admet-3	106	5	shifts	shift	NOUN
admet-3	106	6	of	of	ADP
admet-3	106	7	the	the	DET
admet-3	106	8	methine	methine	ADJ
admet-3	106	9	protons	proton	NOUN
admet-3	106	10	h(2	h(2	PROPN
admet-3	106	11	)	)	PUNCT
admet-3	106	12	,	,	PUNCT
admet-3	106	13	h(2	h(2	NOUN
admet-3	106	14	’	'	PUNCT
admet-3	106	15	)	)	PUNCT
admet-3	106	16	and	and	CCONJ
admet-3	106	17	h(2	h(2	PROPN
admet-3	106	18	”	"	PUNCT
admet-3	106	19	)	)	PUNCT
admet-3	106	20	along	along	ADP
admet-3	106	21	with	with	ADP
admet-3	106	22	the	the	DET
admet-3	106	23	methylenes	methylene	NOUN
admet-3	106	24	h(6	h(6	NOUN
admet-3	106	25	’	'	PUNCT
admet-3	106	26	)	)	PUNCT
admet-3	106	27	,	,	PUNCT
admet-3	106	28	h(3	h(3	PROPN
admet-3	106	29	”	"	PUNCT
admet-3	106	30	)	)	PUNCT
admet-3	106	31	and	and	CCONJ
admet-3	106	32	h(4	h(4	PROPN
admet-3	106	33	”	"	PUNCT
admet-3	106	34	)	)	PUNCT
admet-3	106	35	are	be	AUX
admet-3	106	36	depicted	depict	VERB
admet-3	106	37	as	as	ADP
admet-3	106	38	functions	function	NOUN
admet-3	106	39	of	of	ADP
admet-3	106	40	ph	ph	NOUN
admet-3	106	41	.	.	PUNCT
admet-3	107	1	these	these	DET
admet-3	107	2	six	six	NUM
admet-3	107	3	datasets	dataset	NOUN
admet-3	107	4	were	be	AUX
admet-3	107	5	fitted	fit	VERB
admet-3	107	6	simultaneously	simultaneously	ADV
admet-3	107	7	to	to	ADP
admet-3	107	8	the	the	DET
admet-3	107	9	tetraprotic	tetraprotic	ADJ
admet-3	107	10	macroscopic	macroscopic	ADJ
admet-3	107	11	model	model	NOUN
admet-3	107	12	function	function	NOUN
admet-3	107	13	described	describe	VERB
admet-3	107	14	elsewhere	elsewhere	ADV
admet-3	107	15	[	[	X
admet-3	107	16	26	26	NUM
admet-3	107	17	]	]	PUNCT
admet-3	107	18	.	.	PUNCT
admet-3	108	1	the	the	DET
admet-3	108	2	obtained	obtain	VERB
admet-3	108	3	macroconstants	macroconstant	NOUN
admet-3	108	4	are	be	AUX
admet-3	108	5	shown	show	VERB
admet-3	108	6	in	in	ADP
admet-3	108	7	table	table	NOUN
admet-3	108	8	1	1	NUM
admet-3	108	9	.	.	PUNCT
admet-3	109	1	krisztina	krisztina	PROPN
admet-3	109	2	takács	takács	PROPN
admet-3	109	3	novák	novák	PROPN
admet-3	109	4	et	et	PROPN
admet-3	109	5	al	al	PROPN
admet-3	109	6	.	.	PROPN
admet-3	109	7	admet	admet	PROPN
admet-3	109	8	&	&	CCONJ
admet-3	109	9	dmpk	dmpk	PROPN
admet-3	109	10	1(2	1(2	NUM
admet-3	109	11	)	)	PUNCT
admet-3	109	12	(	(	PUNCT
admet-3	109	13	2013	2013	NUM
admet-3	109	14	)	)	PUNCT
admet-3	109	15	6	6	NUM
admet-3	109	16	-	-	SYM
admet-3	109	17	16	16	NUM
admet-3	109	18	12	12	NUM
admet-3	109	19	table	table	NOUN
admet-3	109	20	1	1	NUM
admet-3	109	21	.	.	PUNCT
admet-3	110	1	protonation	protonation	NOUN
admet-3	110	2	macroconstants	macroconstant	NOUN
admet-3	110	3	measured	measure	VERB
admet-3	110	4	by	by	ADP
admet-3	110	5	different	different	ADJ
admet-3	110	6	methods	method	NOUN
admet-3	110	7	.	.	PUNCT
admet-3	111	1	method	method	NOUN
admet-3	111	2	protonation	protonation	NOUN
admet-3	111	3	macroconstants	macroconstant	NOUN
admet-3	111	4	log	log	VERB
admet-3	111	5	k1	k1	PROPN
admet-3	111	6	±	±	PROPN
admet-3	111	7	sd	sd	ADP
admet-3	111	8	log	log	PROPN
admet-3	111	9	k2	k2	PROPN
admet-3	111	10	±	±	PROPN
admet-3	111	11	sd	sd	ADP
admet-3	111	12	log	log	NOUN
admet-3	111	13	k3	k3	PROPN
admet-3	111	14	±	±	PROPN
admet-3	111	15	sd	sd	ADP
admet-3	111	16	log	log	NOUN
admet-3	111	17	k4	k4	PROPN
admet-3	111	18	±	±	PROPN
admet-3	111	19	sd	sd	ADP
admet-3	111	20	potentiometry	potentiometry	NOUN
admet-3	111	21	in	in	ADP
admet-3	111	22	aqueous	aqueous	ADJ
admet-3	111	23	medium	medium	NOUN
admet-3	111	24	10.74	10.74	NUM
admet-3	111	25	±	±	NUM
admet-3	111	26	0.01	0.01	NUM
admet-3	111	27	7.14	7.14	NUM
admet-3	111	28	±	±	NUM
admet-3	111	29	0.01	0.01	NUM
admet-3	111	30	3.10	3.10	NUM
admet-3	111	31	±	±	NUM
admet-3	111	32	0.01	0.01	NUM
admet-3	111	33	1.54	1.54	NUM
admet-3	111	34	±	±	NUM
admet-3	111	35	0.05	0.05	NUM
admet-3	111	36	potentiometry	potentiometry	NOUN
admet-3	111	37	in	in	ADP
admet-3	111	38	solvent	solvent	NOUN
admet-3	111	39	mixtures	mixture	NOUN
admet-3	111	40	10.75	10.75	NUM
admet-3	111	41	±	±	NUM
admet-3	111	42	0.01	0.01	NUM
admet-3	111	43	7.22	7.22	NUM
admet-3	111	44	±	±	NUM
admet-3	111	45	0.03	0.03	NUM
admet-3	111	46	3.21	3.21	NUM
admet-3	111	47	±	±	NUM
admet-3	111	48	0.02	0.02	NUM
admet-3	111	49	1.62	1.62	NUM
admet-3	111	50	±	±	NUM
admet-3	111	51	0.01	0.01	NUM
admet-3	111	52	nmr	nmr	NOUN
admet-3	111	53	-	-	PUNCT
admet-3	111	54	ph	ph	NOUN
admet-3	111	55	titration	titration	NOUN
admet-3	111	56	10.53	10.53	NUM
admet-3	111	57	±	±	NUM
admet-3	111	58	0.03	0.03	NUM
admet-3	111	59	7.12	7.12	NUM
admet-3	111	60	±	±	NUM
admet-3	111	61	0.01	0.01	NUM
admet-3	111	62	3.15	3.15	NUM
admet-3	111	63	±	±	NUM
admet-3	111	64	0.01	0.01	NUM
admet-3	111	65	1.63	1.63	NUM
admet-3	111	66	±	±	NUM
admet-3	111	67	0.01	0.01	NUM
admet-3	111	68	average	average	NOUN
admet-3	111	69	of	of	ADP
admet-3	111	70	the	the	DET
admet-3	111	71	best	good	ADJ
admet-3	111	72	two	two	NUM
admet-3	111	73	values	value	NOUN
admet-3	111	74	*	*	NOUN
admet-3	111	75	10.75	10.75	NUM
admet-3	111	76	±	±	NUM
admet-3	111	77	0.01	0.01	NUM
admet-3	111	78	7.13	7.13	NUM
admet-3	111	79	±	±	NUM
admet-3	111	80	0.01	0.01	NUM
admet-3	111	81	3.13	3.13	NUM
admet-3	111	82	±	±	NUM
admet-3	111	83	0.01	0.01	NUM
admet-3	111	84	1.63	1.63	NUM
admet-3	111	85	±	±	NUM
admet-3	111	86	0.01	0.01	NUM
admet-3	111	87	*	*	PUNCT
admet-3	111	88	see	see	VERB
admet-3	111	89	details	detail	NOUN
admet-3	111	90	in	in	ADP
admet-3	111	91	text	text	NOUN
admet-3	111	92	figure	figure	NOUN
admet-3	111	93	5	5	NUM
admet-3	111	94	.	.	PUNCT
admet-3	111	95	nmr	nmr	NOUN
admet-3	111	96	-	-	PUNCT
admet-3	111	97	ph	ph	NOUN
admet-3	111	98	titration	titration	NOUN
admet-3	111	99	curves	curve	NOUN
admet-3	111	100	with	with	ADP
admet-3	111	101	computer	computer	NOUN
admet-3	111	102	fitted	fit	VERB
admet-3	111	103	solid	solid	ADJ
admet-3	111	104	line	line	NOUN
admet-3	111	105	the	the	DET
admet-3	111	106	macroconstants	macroconstant	NOUN
admet-3	111	107	(	(	PUNCT
admet-3	111	108	table	table	NOUN
admet-3	111	109	1	1	NUM
admet-3	111	110	)	)	PUNCT
admet-3	111	111	obtained	obtain	VERB
admet-3	111	112	by	by	ADP
admet-3	111	113	different	different	ADJ
admet-3	111	114	methods	method	NOUN
admet-3	111	115	show	show	VERB
admet-3	111	116	generally	generally	ADV
admet-3	111	117	good	good	ADJ
admet-3	111	118	agreement	agreement	NOUN
admet-3	111	119	.	.	PUNCT
admet-3	112	1	the	the	DET
admet-3	112	2	average	average	ADJ
admet-3	112	3	deviation	deviation	NOUN
admet-3	112	4	between	between	ADP
admet-3	112	5	the	the	DET
admet-3	112	6	log	log	NOUN
admet-3	112	7	k	k	PROPN
admet-3	112	8	values	value	NOUN
admet-3	112	9	was	be	AUX
admet-3	112	10	0.09	0.09	NUM
admet-3	112	11	units	unit	NOUN
admet-3	112	12	.	.	PUNCT
admet-3	113	1	the	the	DET
admet-3	113	2	ca	ca	NOUN
admet-3	113	3	.	.	PUNCT
admet-3	114	1	0.2	0.2	NUM
admet-3	114	2	unit	unit	NOUN
admet-3	114	3	discrepancy	discrepancy	NOUN
admet-3	114	4	in	in	ADP
admet-3	114	5	log	log	PROPN
admet-3	114	6	k1	k1	NOUN
admet-3	114	7	between	between	ADP
admet-3	114	8	data	datum	NOUN
admet-3	114	9	acquired	acquire	VERB
admet-3	114	10	by	by	ADP
admet-3	114	11	the	the	DET
admet-3	114	12	nmr	nmr	NOUN
admet-3	114	13	and	and	CCONJ
admet-3	114	14	potentiometric	potentiometric	ADJ
admet-3	114	15	methods	method	NOUN
admet-3	114	16	may	may	AUX
admet-3	114	17	arise	arise	VERB
admet-3	114	18	from	from	ADP
admet-3	114	19	the	the	DET
admet-3	114	20	greater	great	ADJ
admet-3	114	21	ambiguity	ambiguity	NOUN
admet-3	114	22	of	of	ADP
admet-3	114	23	in	in	ADP
admet-3	114	24	situ	situ	ADJ
admet-3	114	25	ph	ph	ADJ
admet-3	114	26	values	value	NOUN
admet-3	114	27	.	.	PUNCT
admet-3	115	1	specifically	specifically	ADV
admet-3	115	2	,	,	PUNCT
admet-3	115	3	trimethylamine	trimethylamine	NOUN
admet-3	115	4	has	have	VERB
admet-3	115	5	a	a	DET
admet-3	115	6	log	log	NOUN
admet-3	115	7	kind	kind	NOUN
admet-3	115	8	=	=	NOUN
admet-3	115	9	9.90	9.90	NUM
admet-3	116	1	[	[	X
admet-3	116	2	23	23	NUM
admet-3	116	3	]	]	PUNCT
admet-3	116	4	and	and	CCONJ
admet-3	116	5	thus	thus	ADV
admet-3	116	6	can	can	AUX
admet-3	116	7	monitor	monitor	VERB
admet-3	116	8	ph	ph	ADJ
admet-3	116	9	values	value	NOUN
admet-3	116	10	higher	high	ADJ
admet-3	116	11	than	than	ADP
admet-3	116	12	admet	admet	PROPN
admet-3	116	13	&	&	CCONJ
admet-3	116	14	dmpk	dmpk	PROPN
admet-3	116	15	1(2	1(2	NUM
admet-3	116	16	)	)	PUNCT
admet-3	116	17	(	(	PUNCT
admet-3	116	18	2013	2013	NUM
admet-3	116	19	)	)	PUNCT
admet-3	116	20	6	6	NUM
admet-3	116	21	-	-	SYM
admet-3	116	22	16	16	NUM
admet-3	116	23	lisinopril	lisinopril	PROPN
admet-3	116	24	speciation	speciation	NOUN
admet-3	116	25	doi	doi	NOUN
admet-3	116	26	:	:	PUNCT
admet-3	116	27	10.5599	10.5599	NUM
admet-3	116	28	/	/	SYM
admet-3	116	29	admet.1.2.3	admet.1.2.3	NOUN
admet-3	116	30	13	13	NUM
admet-3	116	31	10.9	10.9	NUM
admet-3	116	32	with	with	ADP
admet-3	116	33	a	a	DET
admet-3	116	34	lower	low	ADJ
admet-3	116	35	precision	precision	NOUN
admet-3	116	36	(	(	PUNCT
admet-3	116	37	see	see	VERB
admet-3	116	38	the	the	DET
admet-3	116	39	error	error	NOUN
admet-3	116	40	estimations	estimation	NOUN
admet-3	116	41	in	in	ADP
admet-3	116	42	[	[	X
admet-3	116	43	21	21	NUM
admet-3	116	44	]	]	PUNCT
admet-3	116	45	for	for	ADP
admet-3	116	46	details	detail	NOUN
admet-3	116	47	)	)	PUNCT
admet-3	116	48	.	.	PUNCT
admet-3	117	1	in	in	ADP
admet-3	117	2	contrast	contrast	NOUN
admet-3	117	3	,	,	PUNCT
admet-3	117	4	the	the	DET
admet-3	117	5	log	log	NOUN
admet-3	117	6	k4	k4	NOUN
admet-3	117	7	=	=	NOUN
admet-3	117	8	1.63	1.63	NUM
admet-3	117	9	value	value	NOUN
admet-3	117	10	by	by	ADP
admet-3	117	11	nmr	nmr	NOUN
admet-3	117	12	can	can	AUX
admet-3	117	13	be	be	AUX
admet-3	117	14	considered	consider	VERB
admet-3	117	15	as	as	ADP
admet-3	117	16	more	more	ADV
admet-3	117	17	reliable	reliable	ADJ
admet-3	117	18	than	than	ADP
admet-3	117	19	data	datum	NOUN
admet-3	117	20	obtained	obtain	VERB
admet-3	117	21	by	by	ADP
admet-3	117	22	potentiometry	potentiometry	NOUN
admet-3	117	23	in	in	ADP
admet-3	117	24	aqueous	aqueous	ADJ
admet-3	117	25	medium	medium	NOUN
admet-3	117	26	,	,	PUNCT
admet-3	117	27	because	because	SCONJ
admet-3	117	28	below	below	ADP
admet-3	117	29	ph	ph	NOUN
admet-3	117	30	2	2	NUM
admet-3	117	31	,	,	PUNCT
admet-3	117	32	the	the	DET
admet-3	117	33	acidity	acidity	NOUN
admet-3	117	34	error	error	NOUN
admet-3	117	35	of	of	ADP
admet-3	117	36	the	the	DET
admet-3	117	37	electrode	electrode	NOUN
admet-3	117	38	is	be	AUX
admet-3	117	39	considerable	considerable	ADJ
admet-3	117	40	,	,	PUNCT
admet-3	117	41	while	while	SCONJ
admet-3	117	42	here	here	ADV
admet-3	117	43	the	the	DET
admet-3	117	44	nmr	nmr	NOUN
admet-3	117	45	-	-	PUNCT
admet-3	117	46	ph	ph	NOUN
admet-3	117	47	titration	titration	NOUN
admet-3	117	48	as	as	SCONJ
admet-3	117	49	described	describe	VERB
admet-3	117	50	above	above	ADV
admet-3	117	51	is	be	AUX
admet-3	117	52	an	an	DET
admet-3	117	53	electrodeless	electrodeless	NOUN
admet-3	117	54	technique	technique	NOUN
admet-3	117	55	.	.	PUNCT
admet-3	118	1	this	this	DET
admet-3	118	2	constant	constant	ADJ
admet-3	118	3	could	could	AUX
admet-3	118	4	be	be	AUX
admet-3	118	5	determined	determine	VERB
admet-3	118	6	with	with	ADP
admet-3	118	7	excellent	excellent	ADJ
admet-3	118	8	precision	precision	NOUN
admet-3	118	9	from	from	ADP
admet-3	118	10	the	the	DET
admet-3	118	11	extrapolation	extrapolation	NOUN
admet-3	118	12	of	of	ADP
admet-3	118	13	semi	semi	ADJ
admet-3	118	14	-	-	ADJ
admet-3	118	15	aqueous	aqueous	ADJ
admet-3	118	16	logs	log	NOUN
admet-3	118	17	k	k	PROPN
admet-3	118	18	values	value	NOUN
admet-3	118	19	due	due	ADP
admet-3	118	20	to	to	ADP
admet-3	118	21	the	the	DET
admet-3	118	22	reasons	reason	NOUN
admet-3	118	23	mentioned	mention	VERB
admet-3	118	24	above	above	ADV
admet-3	118	25	.	.	PUNCT
admet-3	119	1	however	however	ADV
admet-3	119	2	,	,	PUNCT
admet-3	119	3	we	we	PRON
admet-3	119	4	think	think	VERB
admet-3	119	5	it	it	PRON
admet-3	119	6	reasonable	reasonable	ADJ
admet-3	119	7	to	to	PART
admet-3	119	8	make	make	VERB
admet-3	119	9	an	an	DET
admet-3	119	10	average	average	NOUN
admet-3	119	11	of	of	ADP
admet-3	119	12	the	the	DET
admet-3	119	13	best	good	ADJ
admet-3	119	14	two	two	NUM
admet-3	119	15	experimentally	experimentally	ADV
admet-3	119	16	measured	measure	VERB
admet-3	119	17	logk	logk	ADJ
admet-3	119	18	values	value	NOUN
admet-3	119	19	based	base	VERB
admet-3	119	20	on	on	ADP
admet-3	119	21	the	the	DET
admet-3	119	22	following	follow	VERB
admet-3	119	23	principle	principle	NOUN
admet-3	119	24	.	.	PUNCT
admet-3	120	1	we	we	PRON
admet-3	120	2	omit	omit	VERB
admet-3	120	3	the	the	DET
admet-3	120	4	log	log	NOUN
admet-3	120	5	k	k	PROPN
admet-3	120	6	value	value	NOUN
admet-3	120	7	with	with	ADP
admet-3	120	8	the	the	DET
admet-3	120	9	highest	high	ADJ
admet-3	120	10	uncertainty	uncertainty	NOUN
admet-3	120	11	(	(	PUNCT
admet-3	120	12	the	the	DET
admet-3	120	13	highest	high	ADJ
admet-3	120	14	sd	sd	NOUN
admet-3	120	15	value	value	NOUN
admet-3	120	16	)	)	PUNCT
admet-3	120	17	.	.	PUNCT
admet-3	121	1	the	the	DET
admet-3	121	2	calculated	calculate	VERB
admet-3	121	3	,	,	PUNCT
admet-3	121	4	most	most	ADV
admet-3	121	5	reliable	reliable	ADJ
admet-3	121	6	protonation	protonation	NOUN
admet-3	121	7	macroconstants	macroconstant	NOUN
admet-3	121	8	are	be	AUX
admet-3	121	9	indicated	indicate	VERB
admet-3	121	10	in	in	ADP
admet-3	121	11	the	the	DET
admet-3	121	12	last	last	ADJ
admet-3	121	13	row	row	NOUN
admet-3	121	14	of	of	ADP
admet-3	121	15	table	table	NOUN
admet-3	121	16	1	1	NUM
admet-3	121	17	.	.	PUNCT
admet-3	121	18	comparing	compare	VERB
admet-3	121	19	the	the	DET
admet-3	121	20	obtained	obtain	VERB
admet-3	121	21	logk	logk	ADJ
admet-3	121	22	values	value	NOUN
admet-3	121	23	with	with	ADP
admet-3	121	24	those	those	PRON
admet-3	121	25	reported	report	VERB
admet-3	121	26	in	in	ADP
admet-3	121	27	[	[	X
admet-3	121	28	9	9	NUM
admet-3	121	29	]	]	PUNCT
admet-3	121	30	,	,	PUNCT
admet-3	121	31	the	the	DET
admet-3	121	32	difference	difference	NOUN
admet-3	121	33	was	be	AUX
admet-3	121	34	greater	great	ADJ
admet-3	121	35	than	than	ADP
admet-3	121	36	0.4	0.4	NUM
admet-3	121	37	log	log	NOUN
admet-3	121	38	units	unit	NOUN
admet-3	121	39	in	in	ADP
admet-3	121	40	all	all	DET
admet-3	121	41	log	log	NOUN
admet-3	121	42	k	k	PROPN
admet-3	121	43	values	value	NOUN
admet-3	121	44	.	.	PUNCT
admet-3	122	1	both	both	CCONJ
admet-3	122	2	the	the	DET
admet-3	122	3	log	log	NOUN
admet-3	122	4	k1	k1	NOUN
admet-3	122	5	determined	determine	VERB
admet-3	122	6	by	by	ADP
admet-3	122	7	benion	benion	PROPN
admet-3	122	8	et	et	PROPN
admet-3	122	9	al	al	PROPN
admet-3	122	10	.	.	PUNCT
admet-3	123	1	[	[	X
admet-3	123	2	8	8	NUM
admet-3	123	3	]	]	PUNCT
admet-3	123	4	and	and	CCONJ
admet-3	123	5	the	the	DET
admet-3	123	6	log	log	NOUN
admet-3	123	7	k4	k4	NOUN
admet-3	123	8	reported	report	VERB
admet-3	123	9	by	by	ADP
admet-3	123	10	gonzalez	gonzalez	PROPN
admet-3	123	11	et	et	PROPN
admet-3	123	12	al	al	PROPN
admet-3	123	13	.	.	PUNCT
admet-3	124	1	[	[	X
admet-3	124	2	10	10	NUM
admet-3	124	3	]	]	PUNCT
admet-3	124	4	differ	differ	VERB
admet-3	124	5	remarkably	remarkably	ADV
admet-3	124	6	from	from	ADP
admet-3	124	7	our	our	PRON
admet-3	124	8	data	datum	NOUN
admet-3	124	9	.	.	PUNCT
admet-3	125	1	this	this	PRON
admet-3	125	2	is	be	AUX
admet-3	125	3	not	not	PART
admet-3	125	4	surprising	surprising	ADJ
admet-3	125	5	because	because	SCONJ
admet-3	125	6	those	those	DET
admet-3	125	7	constants	constant	NOUN
admet-3	125	8	were	be	AUX
admet-3	125	9	deduced	deduce	VERB
admet-3	125	10	from	from	ADP
admet-3	125	11	conventional	conventional	ADJ
admet-3	125	12	ph	ph	NOUN
admet-3	125	13	-	-	NOUN
admet-3	125	14	potentiometry	potentiometry	NOUN
admet-3	125	15	in	in	ADP
admet-3	125	16	aqueous	aqueous	ADJ
admet-3	125	17	medium	medium	NOUN
admet-3	125	18	,	,	PUNCT
admet-3	125	19	while	while	SCONJ
admet-3	125	20	the	the	DET
admet-3	125	21	methods	method	NOUN
admet-3	125	22	used	use	VERB
admet-3	125	23	in	in	ADP
admet-3	125	24	our	our	PRON
admet-3	125	25	study	study	NOUN
admet-3	125	26	(	(	PUNCT
admet-3	125	27	potentiometry	potentiometry	NOUN
admet-3	125	28	in	in	ADP
admet-3	125	29	methanol	methanol	NOUN
admet-3	125	30	-	-	PUNCT
admet-3	125	31	water	water	NOUN
admet-3	125	32	mixtures	mixture	NOUN
admet-3	125	33	,	,	PUNCT
admet-3	125	34	1	1	NUM
admet-3	125	35	h	h	NOUN
admet-3	125	36	nmr	nmr	NOUN
admet-3	125	37	-	-	PUNCT
admet-3	125	38	titration	titration	NOUN
admet-3	125	39	)	)	PUNCT
admet-3	125	40	give	give	VERB
admet-3	125	41	more	more	ADJ
admet-3	125	42	reliable	reliable	ADJ
admet-3	125	43	protonation	protonation	NOUN
admet-3	125	44	constants	constant	NOUN
admet-3	125	45	at	at	ADP
admet-3	125	46	ph	ph	ADJ
admet-3	125	47	extremes	extreme	NOUN
admet-3	125	48	.	.	PUNCT
admet-3	126	1	protonation	protonation	NOUN
admet-3	126	2	microconstants	microconstant	NOUN
admet-3	126	3	nevertheless	nevertheless	ADV
admet-3	126	4	,	,	PUNCT
admet-3	126	5	macroscopic	macroscopic	ADJ
admet-3	126	6	constants	constant	NOUN
admet-3	126	7	could	could	AUX
admet-3	126	8	not	not	PART
admet-3	126	9	directly	directly	ADV
admet-3	126	10	be	be	AUX
admet-3	126	11	assigned	assign	VERB
admet-3	126	12	to	to	ADP
admet-3	126	13	functional	functional	ADJ
admet-3	126	14	groups	group	NOUN
admet-3	126	15	,	,	PUNCT
admet-3	126	16	since	since	SCONJ
admet-3	126	17	the	the	DET
admet-3	126	18	difference	difference	NOUN
admet-3	126	19	in	in	ADP
admet-3	126	20	their	their	PRON
admet-3	126	21	logarithms	logarithm	NOUN
admet-3	126	22	did	do	AUX
admet-3	126	23	not	not	PART
admet-3	126	24	exceed	exceed	VERB
admet-3	126	25	3	3	NUM
admet-3	126	26	.	.	PUNCT
admet-3	127	1	the	the	DET
admet-3	127	2	microscopic	microscopic	ADJ
admet-3	127	3	protonation	protonation	NOUN
admet-3	127	4	scheme	scheme	NOUN
admet-3	127	5	in	in	ADP
admet-3	127	6	fig	fig	NOUN
admet-3	127	7	.	.	PUNCT
admet-3	128	1	6	6	NUM
admet-3	128	2	should	should	AUX
admet-3	128	3	be	be	AUX
admet-3	128	4	considered	consider	VERB
admet-3	128	5	for	for	ADP
admet-3	128	6	lisinopril	lisinopril	NOUN
admet-3	128	7	instead	instead	ADV
admet-3	128	8	,	,	PUNCT
admet-3	128	9	where	where	SCONJ
admet-3	128	10	the	the	DET
admet-3	128	11	superscript	superscript	PROPN
admet-3	128	12	on	on	ADP
admet-3	128	13	microconstant	microconstant	PROPN
admet-3	128	14	k	k	PROPN
admet-3	128	15	indicates	indicate	VERB
admet-3	128	16	the	the	DET
admet-3	128	17	group	group	NOUN
admet-3	128	18	protonating	protonate	VERB
admet-3	128	19	in	in	ADP
admet-3	128	20	the	the	DET
admet-3	128	21	equilibrium	equilibrium	NOUN
admet-3	128	22	in	in	ADP
admet-3	128	23	question	question	NOUN
admet-3	128	24	,	,	PUNCT
admet-3	128	25	whereas	whereas	SCONJ
admet-3	128	26	the	the	DET
admet-3	128	27	subscript	subscript	NOUN
admet-3	128	28	(	(	PUNCT
admet-3	128	29	if	if	SCONJ
admet-3	128	30	any	any	PRON
admet-3	128	31	)	)	PUNCT
admet-3	128	32	refers	refer	VERB
admet-3	128	33	to	to	ADP
admet-3	128	34	already	already	ADV
admet-3	128	35	protonated	protonate	VERB
admet-3	128	36	group(s	group(s	NOUN
admet-3	128	37	)	)	PUNCT
admet-3	128	38	.	.	PUNCT
admet-3	129	1	figure	figure	VERB
admet-3	129	2	6	6	NUM
admet-3	129	3	.	.	PUNCT
admet-3	129	4	site	site	NOUN
admet-3	129	5	-	-	PUNCT
admet-3	129	6	specific	specific	ADJ
admet-3	129	7	(	(	PUNCT
admet-3	129	8	microscopic	microscopic	ADJ
admet-3	129	9	)	)	PUNCT
admet-3	129	10	protonation	protonation	NOUN
admet-3	129	11	scheme	scheme	NOUN
admet-3	129	12	of	of	ADP
admet-3	129	13	lisinopril	lisinopril	NOUN
admet-3	129	14	in	in	ADP
admet-3	129	15	the	the	DET
admet-3	129	16	first	first	ADJ
admet-3	129	17	two	two	NUM
admet-3	129	18	well	well	ADV
admet-3	129	19	-	-	PUNCT
admet-3	129	20	separated	separate	VERB
admet-3	129	21	protonation	protonation	NOUN
admet-3	129	22	steps	step	NOUN
admet-3	129	23	,	,	PUNCT
admet-3	129	24	the	the	DET
admet-3	129	25	macroand	macroand	NOUN
admet-3	129	26	microconstants	microconstant	NOUN
admet-3	129	27	are	be	AUX
admet-3	129	28	identical	identical	ADJ
admet-3	129	29	.	.	PUNCT
admet-3	130	1	since	since	SCONJ
admet-3	130	2	the	the	DET
admet-3	130	3	first	first	ADJ
admet-3	130	4	protonation	protonation	NOUN
admet-3	130	5	is	be	AUX
admet-3	130	6	reported	report	VERB
admet-3	130	7	most	most	ADV
admet-3	130	8	sensitively	sensitively	ADV
admet-3	130	9	by	by	ADP
admet-3	130	10	h(6	h(6	NOUN
admet-3	130	11	’	'	PUNCT
admet-3	130	12	)	)	PUNCT
admet-3	130	13	,	,	PUNCT
admet-3	130	14	this	this	DET
admet-3	130	15	protonation	protonation	NOUN
admet-3	130	16	step	step	NOUN
admet-3	130	17	can	can	AUX
admet-3	130	18	be	be	AUX
admet-3	130	19	assigned	assign	VERB
admet-3	130	20	to	to	ADP
admet-3	130	21	the	the	DET
admet-3	130	22	primary	primary	ADJ
admet-3	130	23	amino	amino	NOUN
admet-3	130	24	group	group	NOUN
admet-3	130	25	(	(	PUNCT
admet-3	130	26	log	log	NOUN
admet-3	130	27	k1	k1	NOUN
admet-3	130	28	=	=	PUNCT
admet-3	130	29	log	log	NOUN
admet-3	130	30	ka	ka	PROPN
admet-3	130	31	)	)	PUNCT
admet-3	130	32	.	.	PUNCT
admet-3	131	1	similarly	similarly	ADV
admet-3	131	2	,	,	PUNCT
admet-3	131	3	log	log	PROPN
admet-3	131	4	k2	k2	PROPN
admet-3	131	5	(=	(=	NOUN
admet-3	131	6	log	log	VERB
admet-3	131	7	kb	kb	PROPN
admet-3	131	8	a	a	PRON
admet-3	131	9	)	)	PUNCT
admet-3	131	10	accounts	account	NOUN
admet-3	131	11	for	for	ADP
admet-3	131	12	the	the	DET
admet-3	131	13	secondary	secondary	ADJ
admet-3	131	14	amine	amine	ADJ
admet-3	131	15	basicity	basicity	NOUN
admet-3	131	16	.	.	PUNCT
admet-3	132	1	in	in	ADP
admet-3	132	2	the	the	DET
admet-3	132	3	case	case	NOUN
admet-3	132	4	of	of	ADP
admet-3	132	5	lisinopril	lisinopril	NOUN
admet-3	132	6	,	,	PUNCT
admet-3	132	7	the	the	DET
admet-3	132	8	carboxylates	carboxylate	NOUN
admet-3	132	9	denoted	denote	VERB
admet-3	132	10	by	by	ADP
admet-3	132	11	c	c	PROPN
admet-3	132	12	and	and	CCONJ
admet-3	132	13	d	d	PROPN
admet-3	132	14	exhibit	exhibit	VERB
admet-3	132	15	overlapping	overlap	VERB
admet-3	132	16	protonation	protonation	NOUN
admet-3	132	17	,	,	PUNCT
admet-3	132	18	so	so	ADV
admet-3	132	19	selective	selective	ADJ
admet-3	132	20	monitoring	monitoring	NOUN
admet-3	132	21	of	of	ADP
admet-3	132	22	at	at	ADV
admet-3	132	23	least	least	ADJ
admet-3	132	24	one	one	NUM
admet-3	132	25	of	of	ADP
admet-3	132	26	them	they	PRON
admet-3	132	27	is	be	AUX
admet-3	132	28	a	a	DET
admet-3	132	29	prerequisite	prerequisite	NOUN
admet-3	132	30	for	for	ADP
admet-3	132	31	microconstant	microconstant	ADJ
admet-3	132	32	determination	determination	NOUN
admet-3	132	33	.	.	PUNCT
admet-3	133	1	according	accord	VERB
admet-3	133	2	to	to	ADP
admet-3	133	3	the	the	DET
admet-3	133	4	normalised	normalise	VERB
admet-3	133	5	nmr	nmr	NOUN
admet-3	133	6	titration	titration	NOUN
admet-3	133	7	curves	curve	NOUN
admet-3	133	8	,	,	PUNCT
admet-3	133	9	h(3	h(3	PROPN
admet-3	133	10	”	"	PUNCT
admet-3	133	11	)	)	PUNCT
admet-3	133	12	and	and	CCONJ
admet-3	133	13	h(4	h(4	PROPN
admet-3	133	14	”	"	PUNCT
admet-3	133	15	)	)	PUNCT
admet-3	133	16	can	can	AUX
admet-3	133	17	be	be	AUX
admet-3	133	18	assumed	assume	VERB
admet-3	133	19	as	as	ADP
admet-3	133	20	selective	selective	ADJ
admet-3	133	21	sensors	sensor	NOUN
admet-3	133	22	of	of	ADP
admet-3	133	23	d	d	PROPN
admet-3	133	24	carboxylate	carboxylate	NOUN
admet-3	133	25	protonation	protonation	NOUN
admet-3	133	26	.	.	PUNCT
admet-3	134	1	thus	thus	ADV
admet-3	134	2	,	,	PUNCT
admet-3	134	3	the	the	DET
admet-3	134	4	experimental	experimental	ADJ
admet-3	134	5	chemical	chemical	NOUN
admet-3	134	6	shift	shift	NOUN
admet-3	134	7	profile	profile	NOUN
admet-3	134	8	of	of	ADP
admet-3	134	9	h(3	h(3	NOUN
admet-3	134	10	”	"	PUNCT
admet-3	134	11	)	)	PUNCT
admet-3	134	12	was	be	AUX
admet-3	134	13	fitted	fit	VERB
admet-3	134	14	to	to	ADP
admet-3	134	15	the	the	DET
admet-3	134	16	following	follow	VERB
admet-3	134	17	model	model	NOUN
admet-3	134	18	equation	equation	NOUN
admet-3	134	19	:	:	PUNCT
admet-3	134	20	krisztina	krisztina	AUX
admet-3	134	21	takács	takács	VERB
admet-3	134	22	novák	novák	PROPN
admet-3	134	23	et	et	PROPN
admet-3	134	24	al	al	PROPN
admet-3	134	25	.	.	PROPN
admet-3	134	26	admet	admet	PROPN
admet-3	134	27	&	&	CCONJ
admet-3	134	28	dmpk	dmpk	PROPN
admet-3	134	29	1(2	1(2	NUM
admet-3	134	30	)	)	PUNCT
admet-3	134	31	(	(	PUNCT
admet-3	134	32	2013	2013	NUM
admet-3	134	33	)	)	PUNCT
admet-3	134	34	6	6	NUM
admet-3	134	35	-	-	SYM
admet-3	134	36	16	16	NUM
admet-3	134	37	14	14	NUM
admet-3	134	38	2	2	NUM
admet-3	134	39	2	2	NUM
admet-3	134	40	obs	ob	NOUN
admet-3	134	41	]	]	X
admet-3	135	1	[	[	X
admet-3	135	2	]	]	X
admet-3	135	3	[	[	X
admet-3	135	4	1	1	NUM
admet-3	135	5	]	]	PUNCT
admet-3	135	6	[	[	X
admet-3	135	7	]	]	X
admet-3	135	8	[	[	PUNCT
admet-3	135	9	)	)	PUNCT
admet-3	135	10	(	(	PUNCT
admet-3	135	11			ADJ
admet-3	135	12			PROPN
admet-3	135	13			PROPN
admet-3	135	14			ADJ
admet-3	135	15			NOUN
admet-3	135	16			ADV
admet-3	135	17	hkkhk	hkkhk	NOUN
admet-3	135	18	hkkhk	hkkhk	NOUN
admet-3	135	19	δδδδ	δδδδ	NOUN
admet-3	135	20	433	433	NUM
admet-3	135	21	43	43	NUM
admet-3	135	22	d	d	X
admet-3	135	23	ab	ab	PROPN
admet-3	135	24	lishlishlish	lishlishlish	PROPN
admet-3	135	25	2	2	NUM
admet-3	135	26	2	2	NUM
admet-3	135	27	42	42	NUM
admet-3	135	28	(	(	PUNCT
admet-3	135	29	4	4	NUM
admet-3	135	30	)	)	PUNCT
admet-3	135	31	the	the	DET
admet-3	135	32	microscopic	microscopic	ADJ
admet-3	135	33	evaluation	evaluation	NOUN
admet-3	135	34	resulted	result	VERB
admet-3	135	35	in	in	ADP
admet-3	135	36	log	log	PROPN
admet-3	135	37	d	d	X
admet-3	135	38	abk	abk	PROPN
admet-3	135	39	=	=	SYM
admet-3	135	40	2.15	2.15	NUM
admet-3	135	41	±	±	NUM
admet-3	135	42	0.05	0.05	NUM
admet-3	135	43	(	(	PUNCT
admet-3	135	44	n=	n=	ADJ
admet-3	135	45	2	2	NUM
admet-3	135	46	)	)	PUNCT
admet-3	135	47	which	which	PRON
admet-3	135	48	,	,	PUNCT
admet-3	135	49	in	in	ADP
admet-3	135	50	turn	turn	NOUN
admet-3	135	51	could	could	AUX
admet-3	135	52	be	be	AUX
admet-3	135	53	converted	convert	VERB
admet-3	135	54	to	to	ADP
admet-3	135	55	the	the	DET
admet-3	135	56	remaining	remain	VERB
admet-3	135	57	three	three	NUM
admet-3	135	58	microconstants	microconstant	NOUN
admet-3	135	59	,	,	PUNCT
admet-3	135	60	using	use	VERB
admet-3	135	61	the	the	DET
admet-3	135	62	following	follow	VERB
admet-3	135	63	hessian	hessian	ADJ
admet-3	135	64	constraints	constraint	NOUN
admet-3	135	65	:	:	PUNCT
admet-3	135	66	3	3	NUM
admet-3	135	67	c	c	NOUN
admet-3	135	68	ab	ab	PROPN
admet-3	136	1	d	d	X
admet-3	136	2	ab	ab	PROPN
admet-3	136	3	kkk	kkk	PROPN
admet-3	136	4			X
admet-3	136	5	(	(	PUNCT
admet-3	136	6	5	5	NUM
admet-3	136	7	)	)	PUNCT
admet-3	136	8	43	43	NUM
admet-3	137	1	d	d	NOUN
admet-3	137	2	abc	abc	PROPN
admet-3	137	3	c	c	PROPN
admet-3	137	4	ab	ab	PROPN
admet-3	137	5	c	c	PROPN
admet-3	137	6	abd	abd	PROPN
admet-3	138	1	d	d	PROPN
admet-3	138	2	ab	ab	PROPN
admet-3	138	3	kkkkkk	kkkkkk	PROPN
admet-3	138	4			NUM
admet-3	138	5	(	(	PUNCT
admet-3	138	6	6	6	NUM
admet-3	138	7	)	)	PUNCT
admet-3	138	8	we	we	PRON
admet-3	138	9	obtained	obtain	VERB
admet-3	138	10	log	log	NOUN
admet-3	138	11	c	c	NOUN
admet-3	138	12	abdk	abdk	PROPN
admet-3	138	13	=	=	SYM
admet-3	138	14	2.63	2.63	NUM
admet-3	138	15	,	,	PUNCT
admet-3	138	16	log	log	NOUN
admet-3	138	17	c	c	PROPN
admet-3	138	18	abk	abk	PROPN
admet-3	138	19	=	=	PUNCT
admet-3	138	20	3.10	3.10	NUM
admet-3	138	21	and	and	CCONJ
admet-3	138	22	log	log	VERB
admet-3	138	23	d	d	NOUN
admet-3	138	24	abck	abck	NOUN
admet-3	138	25	=	=	SYM
admet-3	138	26	1.68	1.68	NUM
admet-3	138	27	(	(	PUNCT
admet-3	138	28	with	with	ADP
admet-3	138	29	estimated	estimate	VERB
admet-3	138	30	uncertainties	uncertainty	NOUN
admet-3	138	31	of	of	ADP
admet-3	138	32	0.05	0.05	NUM
admet-3	138	33	)	)	PUNCT
admet-3	138	34	.	.	PUNCT
admet-3	139	1	the	the	DET
admet-3	139	2	main	main	ADJ
admet-3	139	3	pathway	pathway	NOUN
admet-3	139	4	of	of	ADP
admet-3	139	5	protonation	protonation	NOUN
admet-3	139	6	includes	include	VERB
admet-3	139	7	the	the	DET
admet-3	139	8	abc	abc	PROPN
admet-3	139	9	microspecies	microspecie	NOUN
admet-3	139	10	,	,	PUNCT
admet-3	139	11	while	while	SCONJ
admet-3	139	12	its	its	PRON
admet-3	139	13	minor	minor	ADJ
admet-3	139	14	protonation	protonation	NOUN
admet-3	139	15	isomer	isomer	NOUN
admet-3	139	16	(	(	PUNCT
admet-3	139	17	abd	abd	NOUN
admet-3	139	18	)	)	PUNCT
admet-3	139	19	has	have	VERB
admet-3	139	20	nine	nine	NUM
admet-3	139	21	times	time	NOUN
admet-3	139	22	lower	low	ADJ
admet-3	139	23	abundance	abundance	NOUN
admet-3	139	24	at	at	ADP
admet-3	139	25	all	all	DET
admet-3	139	26	ph	ph	ADJ
admet-3	139	27	values	value	NOUN
admet-3	139	28	.	.	PUNCT
admet-3	140	1	in	in	ADP
admet-3	140	2	other	other	ADJ
admet-3	140	3	words	word	NOUN
admet-3	140	4	,	,	PUNCT
admet-3	140	5	the	the	DET
admet-3	140	6	carboxylate	carboxylate	NOUN
admet-3	140	7	on	on	ADP
admet-3	140	8	the	the	DET
admet-3	140	9	proline	proline	NOUN
admet-3	140	10	ring	ring	NOUN
admet-3	140	11	exhibits	exhibit	VERB
admet-3	140	12	nine	nine	NUM
admet-3	140	13	times	time	NOUN
admet-3	140	14	greater	great	ADJ
admet-3	140	15	intrinsic	intrinsic	ADJ
admet-3	140	16	basicity	basicity	NOUN
admet-3	140	17	than	than	ADP
admet-3	140	18	the	the	DET
admet-3	140	19	carboxylate	carboxylate	NOUN
admet-3	140	20	on	on	ADP
admet-3	140	21	the	the	DET
admet-3	140	22	side	side	NOUN
admet-3	140	23	chain	chain	NOUN
admet-3	140	24	with	with	ADP
admet-3	140	25	an	an	DET
admet-3	140	26	adjacent	adjacent	ADJ
admet-3	140	27	,	,	PUNCT
admet-3	140	28	electron	electron	NOUN
admet-3	140	29	-	-	PUNCT
admet-3	140	30	attracting	attract	VERB
admet-3	140	31	protonated	protonate	VERB
admet-3	140	32	secondary	secondary	ADJ
admet-3	140	33	amine	amine	NOUN
admet-3	140	34	(	(	PUNCT
admet-3	140	35	-nh2	-nh2	PROPN
admet-3	140	36	+	+	CCONJ
admet-3	140	37	-	-	PUNCT
admet-3	140	38	)	)	PUNCT
admet-3	140	39	group	group	NOUN
admet-3	140	40	.	.	PUNCT
admet-3	141	1	the	the	DET
admet-3	141	2	mutual	mutual	ADJ
admet-3	141	3	basicity	basicity	NOUN
admet-3	141	4	-	-	PUNCT
admet-3	141	5	modifying	modify	VERB
admet-3	141	6	effect	effect	NOUN
admet-3	141	7	of	of	ADP
admet-3	141	8	these	these	DET
admet-3	141	9	moieties	moiety	NOUN
admet-3	141	10	is	be	AUX
admet-3	141	11	quantified	quantify	VERB
admet-3	141	12	by	by	ADP
admet-3	141	13	the	the	DET
admet-3	141	14	interactivity	interactivity	NOUN
admet-3	141	15	parameter	parameter	NOUN
admet-3	141	16	,	,	PUNCT
admet-3	141	17	defined	define	VERB
admet-3	141	18	as	as	ADP
admet-3	141	19	the	the	DET
admet-3	141	20	difference	difference	NOUN
admet-3	141	21	in	in	ADP
admet-3	141	22	the	the	DET
admet-3	141	23	corresponding	correspond	VERB
admet-3	141	24	microconstants	microconstant	NOUN
admet-3	141	25	:	:	PUNCT
admet-3	141	26	pecd	pecd	NOUN
admet-3	141	27	=	=	SYM
admet-3	141	28	2.15	2.15	NUM
admet-3	141	29	–	–	PUNCT
admet-3	141	30	1.68	1.68	NUM
admet-3	141	31	=	=	SYM
admet-3	141	32	3.10	3.10	NUM
admet-3	141	33	–	–	PUNCT
admet-3	141	34	2.63	2.63	NUM
admet-3	141	35	=	=	SYM
admet-3	141	36	0.47	0.47	NUM
admet-3	141	37	.	.	PUNCT
admet-3	142	1	this	this	DET
admet-3	142	2	pe	pe	PROPN
admet-3	142	3	value	value	NOUN
admet-3	142	4	suggests	suggest	VERB
admet-3	142	5	an	an	DET
admet-3	142	6	interaction	interaction	NOUN
admet-3	142	7	exceeding	exceed	VERB
admet-3	142	8	the	the	DET
admet-3	142	9	random	random	ADJ
admet-3	142	10	,	,	PUNCT
admet-3	142	11	coulombic	coulombic	ADJ
admet-3	142	12	value	value	NOUN
admet-3	142	13	of	of	ADP
admet-3	142	14	0.2	0.2	NUM
admet-3	142	15	-	-	SYM
admet-3	142	16	0.3	0.3	NUM
admet-3	143	1	[	[	X
admet-3	143	2	27	27	NUM
admet-3	143	3	]	]	PUNCT
admet-3	143	4	;	;	PUNCT
admet-3	143	5	presumably	presumably	ADV
admet-3	143	6	,	,	PUNCT
admet-3	143	7	these	these	DET
admet-3	143	8	sites	site	NOUN
admet-3	143	9	communicate	communicate	VERB
admet-3	143	10	through	through	ADP
admet-3	143	11	space	space	NOUN
admet-3	143	12	with	with	ADP
admet-3	143	13	a	a	DET
admet-3	143	14	simultaneous	simultaneous	ADJ
admet-3	143	15	change	change	NOUN
admet-3	143	16	in	in	ADP
admet-3	143	17	their	their	PRON
admet-3	143	18	geometric	geometric	ADJ
admet-3	143	19	positions	position	NOUN
admet-3	143	20	.	.	PUNCT
admet-3	144	1	a	a	DET
admet-3	144	2	conformational	conformational	ADJ
admet-3	144	3	change	change	NOUN
admet-3	144	4	at	at	ADP
admet-3	144	5	ph	ph	PROPN
admet-3	144	6	<	<	X
admet-3	144	7	4.5	4.5	NUM
admet-3	144	8	is	be	AUX
admet-3	144	9	also	also	ADV
admet-3	144	10	substantiated	substantiate	VERB
admet-3	144	11	by	by	ADP
admet-3	144	12	the	the	DET
admet-3	144	13	changing	change	VERB
admet-3	144	14	multiplet	multiplet	NOUN
admet-3	144	15	patterns	pattern	NOUN
admet-3	144	16	in	in	ADP
admet-3	144	17	the	the	DET
admet-3	144	18	nmr	nmr	NOUN
admet-3	144	19	spectra	spectra	NOUN
admet-3	144	20	,	,	PUNCT
admet-3	144	21	but	but	CCONJ
admet-3	144	22	a	a	DET
admet-3	144	23	detailed	detailed	ADJ
admet-3	144	24	analysis	analysis	NOUN
admet-3	144	25	of	of	ADP
admet-3	144	26	vicinal	vicinal	ADJ
admet-3	144	27	3jhh	3jhh	PROPN
admet-3	144	28	values	value	NOUN
admet-3	144	29	holding	hold	VERB
admet-3	144	30	conformational	conformational	ADJ
admet-3	144	31	information	information	NOUN
admet-3	144	32	is	be	AUX
admet-3	144	33	beyond	beyond	ADP
admet-3	144	34	the	the	DET
admet-3	144	35	scope	scope	NOUN
admet-3	144	36	of	of	ADP
admet-3	144	37	this	this	DET
admet-3	144	38	article	article	NOUN
admet-3	144	39	.	.	PUNCT
admet-3	145	1	distribution	distribution	NOUN
admet-3	145	2	of	of	ADP
admet-3	145	3	protonation	protonation	NOUN
admet-3	145	4	species	specie	NOUN
admet-3	145	5	using	use	VERB
admet-3	145	6	log	log	NOUN
admet-3	145	7	k	k	PROPN
admet-3	145	8	and	and	CCONJ
admet-3	145	9	log	log	VERB
admet-3	145	10	k	k	PROPN
admet-3	145	11	values	value	NOUN
admet-3	145	12	,	,	PUNCT
admet-3	145	13	the	the	DET
admet-3	145	14	percentage	percentage	NOUN
admet-3	145	15	of	of	ADP
admet-3	145	16	various	various	ADJ
admet-3	145	17	protonated	protonate	VERB
admet-3	145	18	species	specie	NOUN
admet-3	145	19	can	can	AUX
admet-3	145	20	be	be	AUX
admet-3	145	21	calculated	calculate	VERB
admet-3	145	22	for	for	ADP
admet-3	145	23	any	any	DET
admet-3	145	24	arbitrary	arbitrary	ADJ
admet-3	145	25	ph	ph	ADJ
admet-3	145	26	value	value	NOUN
admet-3	145	27	.	.	PUNCT
admet-3	146	1	the	the	DET
admet-3	146	2	distribution	distribution	NOUN
admet-3	146	3	ratios	ratio	NOUN
admet-3	146	4	of	of	ADP
admet-3	146	5	each	each	DET
admet-3	146	6	species	specie	NOUN
admet-3	146	7	as	as	ADP
admet-3	146	8	a	a	DET
admet-3	146	9	function	function	NOUN
admet-3	146	10	of	of	ADP
admet-3	146	11	ph	ph	NOUN
admet-3	146	12	are	be	AUX
admet-3	146	13	shown	show	VERB
admet-3	146	14	in	in	ADP
admet-3	146	15	fig	fig	NOUN
admet-3	146	16	.	.	PUNCT
admet-3	147	1	7	7	X
admet-3	147	2	.	.	X
admet-3	147	3	figure	figure	NOUN
admet-3	147	4	7	7	NUM
admet-3	147	5	.	.	PUNCT
admet-3	147	6	distribution	distribution	NOUN
admet-3	147	7	curves	curve	NOUN
admet-3	147	8	of	of	ADP
admet-3	147	9	the	the	DET
admet-3	147	10	macrospecies	macrospecie	NOUN
admet-3	147	11	(	(	PUNCT
admet-3	147	12	hilis	hilis	PROPN
admet-3	147	13	)	)	PUNCT
admet-3	147	14	and	and	CCONJ
admet-3	147	15	microspecies	microspecie	NOUN
admet-3	147	16	(	(	PUNCT
admet-3	147	17	abc	abc	PROPN
admet-3	147	18	and	and	CCONJ
admet-3	147	19	abd	abd	PROPN
admet-3	147	20	)	)	PUNCT
admet-3	147	21	of	of	ADP
admet-3	147	22	lisinopril	lisinopril	PROPN
admet-3	147	23	admet	admet	PROPN
admet-3	147	24	&	&	CCONJ
admet-3	147	25	dmpk	dmpk	PROPN
admet-3	147	26	1(2	1(2	NUM
admet-3	147	27	)	)	PUNCT
admet-3	147	28	(	(	PUNCT
admet-3	147	29	2013	2013	NUM
admet-3	147	30	)	)	PUNCT
admet-3	147	31	6	6	NUM
admet-3	147	32	-	-	SYM
admet-3	147	33	16	16	NUM
admet-3	147	34	lisinopril	lisinopril	PROPN
admet-3	147	35	speciation	speciation	NOUN
admet-3	147	36	doi	doi	NOUN
admet-3	147	37	:	:	PUNCT
admet-3	147	38	10.5599	10.5599	NUM
admet-3	147	39	/	/	SYM
admet-3	147	40	admet.1.2.3	admet.1.2.3	NOUN
admet-3	147	41	15	15	NUM
admet-3	147	42	table	table	NOUN
admet-3	147	43	2	2	NUM
admet-3	147	44	summarises	summarise	VERB
admet-3	147	45	the	the	DET
admet-3	147	46	relative	relative	ADJ
admet-3	147	47	concentration	concentration	NOUN
admet-3	147	48	of	of	ADP
admet-3	147	49	lisinopril	lisinopril	NOUN
admet-3	147	50	protonation	protonation	NOUN
admet-3	147	51	species	specie	NOUN
admet-3	147	52	at	at	ADP
admet-3	147	53	the	the	DET
admet-3	147	54	most	most	ADV
admet-3	147	55	relevant	relevant	ADJ
admet-3	147	56	ph	ph	ADJ
admet-3	147	57	values	value	NOUN
admet-3	147	58	in	in	ADP
admet-3	147	59	the	the	DET
admet-3	147	60	body	body	NOUN
admet-3	147	61	.	.	PUNCT
admet-3	148	1	in	in	ADP
admet-3	148	2	the	the	DET
admet-3	148	3	stomach	stomach	NOUN
admet-3	148	4	,	,	PUNCT
admet-3	148	5	the	the	DET
admet-3	148	6	monocation	monocation	NOUN
admet-3	148	7	(	(	PUNCT
admet-3	148	8	h3lis	h3lis	PROPN
admet-3	148	9	+	+	NUM
admet-3	148	10	)	)	PUNCT
admet-3	148	11	and	and	CCONJ
admet-3	148	12	the	the	DET
admet-3	148	13	dication	dication	NOUN
admet-3	148	14	(	(	PUNCT
admet-3	148	15	h4lis	h4li	NOUN
admet-3	148	16	2	2	NUM
admet-3	148	17	+	+	NUM
admet-3	148	18	)	)	PUNCT
admet-3	148	19	forms	form	NOUN
admet-3	148	20	are	be	AUX
admet-3	148	21	present	present	ADJ
admet-3	148	22	at	at	ADP
admet-3	148	23	about	about	ADP
admet-3	148	24	equal	equal	ADJ
admet-3	148	25	levels	level	NOUN
admet-3	148	26	.	.	PUNCT
admet-3	149	1	in	in	ADP
admet-3	149	2	the	the	DET
admet-3	149	3	gastrointestinal	gastrointestinal	ADJ
admet-3	149	4	tract	tract	NOUN
admet-3	149	5	,	,	PUNCT
admet-3	149	6	the	the	DET
admet-3	149	7	double	double	ADJ
admet-3	149	8	protonated	protonate	VERB
admet-3	149	9	h2lis	h2lis	PROPN
admet-3	149	10	form	form	NOUN
admet-3	149	11	predominates	predominate	VERB
admet-3	149	12	,	,	PUNCT
admet-3	149	13	while	while	SCONJ
admet-3	149	14	at	at	ADP
admet-3	149	15	the	the	DET
admet-3	149	16	ph	ph	NOUN
admet-3	149	17	of	of	ADP
admet-3	149	18	plasma	plasma	NOUN
admet-3	149	19	,	,	PUNCT
admet-3	149	20	the	the	DET
admet-3	149	21	monoanion	monoanion	NOUN
admet-3	149	22	(	(	PUNCT
admet-3	149	23	hlis	hlis	PROPN
admet-3	149	24	)	)	PUNCT
admet-3	149	25	is	be	AUX
admet-3	149	26	the	the	DET
admet-3	149	27	dominant	dominant	ADJ
admet-3	149	28	species	specie	NOUN
admet-3	149	29	.	.	PUNCT
admet-3	150	1	table	table	NOUN
admet-3	150	2	2	2	NUM
admet-3	150	3	.	.	PUNCT
admet-3	151	1	the	the	DET
admet-3	151	2	percentage	percentage	NOUN
admet-3	151	3	concentration	concentration	NOUN
admet-3	151	4	of	of	ADP
admet-3	151	5	the	the	DET
admet-3	151	6	species	specie	NOUN
admet-3	151	7	in	in	ADP
admet-3	151	8	the	the	DET
admet-3	151	9	stomach	stomach	NOUN
admet-3	151	10	(	(	PUNCT
admet-3	151	11	ph	ph	NOUN
admet-3	151	12	1.5	1.5	NUM
admet-3	151	13	)	)	PUNCT
admet-3	151	14	,	,	PUNCT
admet-3	151	15	gastrointestinal	gastrointestinal	ADJ
admet-3	151	16	tract	tract	NOUN
admet-3	151	17	(	(	PUNCT
admet-3	151	18	jejunum	jejunum	ADJ
admet-3	151	19	ph	ph	NOUN
admet-3	151	20	6.5	6.5	NUM
admet-3	151	21	)	)	PUNCT
admet-3	151	22	and	and	CCONJ
admet-3	151	23	plasma	plasma	NOUN
admet-3	151	24	(	(	PUNCT
admet-3	151	25	ph	ph	NOUN
admet-3	151	26	7.4	7.4	NUM
admet-3	151	27	)	)	PUNCT
admet-3	151	28	.	.	PUNCT
admet-3	152	1	form	form	NOUN
admet-3	152	2	of	of	ADP
admet-3	152	3	the	the	DET
admet-3	152	4	species	species	NOUN
admet-3	152	5	percentage	percentage	NOUN
admet-3	152	6	concentration	concentration	NOUN
admet-3	152	7	stomach	stomach	NOUN
admet-3	152	8	ph	ph	VERB
admet-3	152	9	1.5	1.5	NUM
admet-3	152	10	gi	gi	NOUN
admet-3	152	11	tract	tract	NOUN
admet-3	152	12	(	(	PUNCT
admet-3	152	13	jejunum	jejunum	ADJ
admet-3	152	14	)	)	PUNCT
admet-3	152	15	ph	ph	PROPN
admet-3	152	16	6.5	6.5	NUM
admet-3	152	17	plasma	plasma	NOUN
admet-3	152	18	ph	ph	NOUN
admet-3	152	19	7.4	7.4	NUM
admet-3	152	20	lis	li	NOUN
admet-3	152	21	2	2	NUM
admet-3	152	22	0.00	0.00	NUM
admet-3	152	23	0.00	0.00	NUM
admet-3	152	24	0.03	0.03	NUM
admet-3	152	25	hlis0.00	hlis0.00	PROPN
admet-3	152	26	18.98	18.98	NUM
admet-3	152	27	65.04	65.04	NUM
admet-3	152	28	h2lis	h2lis	PROPN
admet-3	152	29	0.99	0.99	NUM
admet-3	152	30	80.98	80.98	NUM
admet-3	152	31	34.93	34.93	NUM
admet-3	152	32	h3lis	h3li	NOUN
admet-3	152	33	+	+	CCONJ
admet-3	152	34	42.15	42.15	NUM
admet-3	152	35	0.03	0.03	NUM
admet-3	152	36	0.00	0.00	NUM
admet-3	152	37	h4lis	h4li	NOUN
admet-3	152	38	2	2	NUM
admet-3	152	39	+	+	SYM
admet-3	152	40	56.86	56.86	NUM
admet-3	152	41	0.00	0.00	NUM
admet-3	152	42	0.00	0.00	NUM
admet-3	152	43	conclusions	conclusion	NOUN
admet-3	152	44	in	in	ADP
admet-3	152	45	this	this	DET
admet-3	152	46	study	study	NOUN
admet-3	152	47	,	,	PUNCT
admet-3	152	48	the	the	DET
admet-3	152	49	acid	acid	NOUN
admet-3	152	50	-	-	PUNCT
admet-3	152	51	base	base	NOUN
admet-3	152	52	chemistry	chemistry	NOUN
admet-3	152	53	of	of	ADP
admet-3	152	54	tetraprotic	tetraprotic	ADJ
admet-3	152	55	lisinopril	lisinopril	PROPN
admet-3	152	56	was	be	AUX
admet-3	152	57	characterised	characterise	VERB
admet-3	152	58	by	by	ADP
admet-3	152	59	protonation	protonation	NOUN
admet-3	152	60	macro	macro	NOUN
admet-3	152	61	and	and	CCONJ
admet-3	152	62	microconstants	microconstant	NOUN
admet-3	152	63	.	.	PUNCT
admet-3	153	1	the	the	DET
admet-3	153	2	highly	highly	ADV
admet-3	153	3	precise	precise	ADJ
admet-3	153	4	log	log	NOUN
admet-3	153	5	k	k	PROPN
admet-3	153	6	values	value	NOUN
admet-3	153	7	obtained	obtain	VERB
admet-3	153	8	by	by	ADP
admet-3	153	9	two	two	NUM
admet-3	153	10	independent	independent	ADJ
admet-3	153	11	analytical	analytical	ADJ
admet-3	153	12	methods	method	NOUN
admet-3	153	13	provided	provide	VERB
admet-3	153	14	a	a	DET
admet-3	153	15	better	well	ADJ
admet-3	153	16	interpretation	interpretation	NOUN
admet-3	153	17	of	of	ADP
admet-3	153	18	the	the	DET
admet-3	153	19	pk	pk	PROPN
admet-3	153	20	/	/	SYM
admet-3	153	21	pd	pd	NOUN
admet-3	153	22	properties	property	NOUN
admet-3	153	23	.	.	PUNCT
admet-3	154	1	as	as	SCONJ
admet-3	154	2	fig	fig	NOUN
admet-3	154	3	.	.	PUNCT
admet-3	154	4	7	7	NUM
admet-3	154	5	indicates	indicate	VERB
admet-3	154	6	,	,	PUNCT
admet-3	154	7	under	under	ADP
admet-3	154	8	the	the	DET
admet-3	154	9	ph	ph	ADJ
admet-3	154	10	conditions	condition	NOUN
admet-3	154	11	of	of	ADP
admet-3	154	12	the	the	DET
admet-3	154	13	gi	gi	NOUN
admet-3	154	14	tract	tract	NOUN
admet-3	154	15	–	–	PUNCT
admet-3	154	16	the	the	DET
admet-3	154	17	most	most	ADV
admet-3	154	18	likely	likely	ADJ
admet-3	154	19	site	site	NOUN
admet-3	154	20	of	of	ADP
admet-3	154	21	oral	oral	ADJ
admet-3	154	22	absorption	absorption	NOUN
admet-3	154	23	–	–	PUNCT
admet-3	154	24	lisinopril	lisinopril	NOUN
admet-3	154	25	is	be	AUX
admet-3	154	26	predominantly	predominantly	ADV
admet-3	154	27	present	present	ADJ
admet-3	154	28	in	in	ADP
admet-3	154	29	the	the	DET
admet-3	154	30	h2lis	h2lis	PROPN
admet-3	154	31	form	form	NOUN
admet-3	154	32	.	.	PUNCT
admet-3	155	1	although	although	SCONJ
admet-3	155	2	the	the	DET
admet-3	155	3	net	net	ADJ
admet-3	155	4	charge	charge	NOUN
admet-3	155	5	of	of	ADP
admet-3	155	6	this	this	DET
admet-3	155	7	species	species	NOUN
admet-3	155	8	is	be	AUX
admet-3	155	9	zero	zero	NUM
admet-3	155	10	,	,	PUNCT
admet-3	155	11	the	the	DET
admet-3	155	12	molecule	molecule	NOUN
admet-3	155	13	exists	exist	VERB
admet-3	155	14	in	in	ADP
admet-3	155	15	solution	solution	NOUN
admet-3	155	16	as	as	ADP
admet-3	155	17	a	a	DET
admet-3	155	18	double	double	ADJ
admet-3	155	19	zwitterion	zwitterion	NOUN
admet-3	155	20	:	:	PUNCT
admet-3	155	21	the	the	DET
admet-3	155	22	two	two	NUM
admet-3	155	23	amine	amine	ADJ
admet-3	155	24	functions	function	NOUN
admet-3	155	25	are	be	AUX
admet-3	155	26	protonated	protonate	VERB
admet-3	155	27	while	while	SCONJ
admet-3	155	28	the	the	DET
admet-3	155	29	two	two	NUM
admet-3	155	30	carboxylates	carboxylate	NOUN
admet-3	155	31	are	be	AUX
admet-3	155	32	not	not	PART
admet-3	155	33	.	.	PUNCT
admet-3	156	1	this	this	DET
admet-3	156	2	structure	structure	NOUN
admet-3	156	3	represents	represent	VERB
admet-3	156	4	a	a	DET
admet-3	156	5	highly	highly	ADV
admet-3	156	6	polar	polar	ADJ
admet-3	156	7	dipole	dipole	NOUN
admet-3	156	8	that	that	PRON
admet-3	156	9	is	be	AUX
admet-3	156	10	unfavourable	unfavourable	ADJ
admet-3	156	11	for	for	ADP
admet-3	156	12	passive	passive	ADJ
admet-3	156	13	transport	transport	NOUN
admet-3	156	14	through	through	ADP
admet-3	156	15	lipoid	lipoid	ADJ
admet-3	156	16	membranes	membrane	NOUN
admet-3	156	17	,	,	PUNCT
admet-3	156	18	which	which	PRON
admet-3	156	19	explains	explain	VERB
admet-3	156	20	the	the	DET
admet-3	156	21	low	low	ADJ
admet-3	156	22	bioavailability	bioavailability	NOUN
admet-3	156	23	of	of	ADP
admet-3	156	24	the	the	DET
admet-3	156	25	molecule	molecule	NOUN
admet-3	156	26	.	.	PUNCT
admet-3	157	1	recently	recently	ADV
admet-3	157	2	,	,	PUNCT
admet-3	157	3	the	the	DET
admet-3	157	4	intestinal	intestinal	ADJ
admet-3	157	5	dipeptide	dipeptide	NOUN
admet-3	157	6	transporter	transporter	NOUN
admet-3	157	7	system	system	NOUN
admet-3	157	8	(	(	PUNCT
admet-3	157	9	dts	dts	NOUN
admet-3	157	10	)	)	PUNCT
admet-3	157	11	has	have	AUX
admet-3	157	12	been	be	AUX
admet-3	157	13	reported	report	VERB
admet-3	157	14	to	to	PART
admet-3	157	15	be	be	AUX
admet-3	157	16	involved	involve	VERB
admet-3	157	17	in	in	ADP
admet-3	157	18	the	the	DET
admet-3	157	19	active	active	ADJ
admet-3	157	20	transport	transport	NOUN
admet-3	157	21	mechanism	mechanism	NOUN
admet-3	157	22	of	of	ADP
admet-3	157	23	oral	oral	ADJ
admet-3	157	24	absorption	absorption	NOUN
admet-3	157	25	of	of	ADP
admet-3	157	26	ace	ace	ADJ
admet-3	157	27	inhibitors	inhibitor	NOUN
admet-3	157	28	[	[	X
admet-3	157	29	28	28	NUM
admet-3	157	30	]	]	PUNCT
admet-3	157	31	.	.	PUNCT
admet-3	158	1	at	at	ADP
admet-3	158	2	the	the	DET
admet-3	158	3	ph	ph	NOUN
admet-3	158	4	of	of	ADP
admet-3	158	5	the	the	DET
admet-3	158	6	plasma	plasma	NOUN
admet-3	158	7	,	,	PUNCT
admet-3	158	8	the	the	DET
admet-3	158	9	monoanion	monoanion	NOUN
admet-3	158	10	(	(	PUNCT
admet-3	158	11	hlis-	hlis-	NOUN
admet-3	158	12	)	)	PUNCT
admet-3	158	13	is	be	AUX
admet-3	158	14	the	the	DET
admet-3	158	15	dominant	dominant	ADJ
admet-3	158	16	form	form	NOUN
admet-3	158	17	(	(	PUNCT
admet-3	158	18	more	more	ADJ
admet-3	158	19	than	than	ADP
admet-3	158	20	60	60	NUM
admet-3	158	21	%	%	NOUN
admet-3	158	22	)	)	PUNCT
admet-3	158	23	,	,	PUNCT
admet-3	158	24	which	which	PRON
admet-3	158	25	favours	favour	VERB
admet-3	158	26	receptor	receptor	NOUN
admet-3	158	27	binding	bind	VERB
admet-3	158	28	.	.	PUNCT
admet-3	159	1	as	as	SCONJ
admet-3	159	2	is	be	AUX
admet-3	159	3	known	know	VERB
admet-3	159	4	,	,	PUNCT
admet-3	159	5	therapeutically	therapeutically	ADV
admet-3	159	6	useful	useful	ADJ
admet-3	159	7	ace	ace	NOUN
admet-3	159	8	inhibitors	inhibitor	NOUN
admet-3	159	9	exhibit	exhibit	VERB
admet-3	159	10	three	three	NUM
admet-3	159	11	-	-	PUNCT
admet-3	159	12	point	point	NOUN
admet-3	159	13	binding	bind	VERB
admet-3	159	14	to	to	ADP
admet-3	159	15	the	the	DET
admet-3	159	16	zn	zn	PROPN
admet-3	159	17	ion	ion	NOUN
admet-3	159	18	-	-	PUNCT
admet-3	159	19	containing	contain	VERB
admet-3	159	20	carbopeptidase	carbopeptidase	NOUN
admet-3	159	21	ace	ace	NOUN
admet-3	159	22	enzyme	enzyme	NOUN
admet-3	159	23	[	[	NOUN
admet-3	159	24	2	2	NUM
admet-3	159	25	]	]	PUNCT
admet-3	159	26	.	.	PUNCT
admet-3	160	1	the	the	DET
admet-3	160	2	proline	proline	NOUN
admet-3	160	3	c2	c2	PROPN
admet-3	160	4	-	-	PUNCT
admet-3	160	5	carboxylate	carboxylate	NOUN
admet-3	160	6	of	of	ADP
admet-3	160	7	lisinopril	lisinopril	PROPN
admet-3	160	8	binds	bind	VERB
admet-3	160	9	to	to	ADP
admet-3	160	10	the	the	DET
admet-3	160	11	positively	positively	ADV
admet-3	160	12	charged	charge	VERB
admet-3	160	13	arg146	arg146	PROPN
admet-3	160	14	,	,	PUNCT
admet-3	160	15	while	while	SCONJ
admet-3	160	16	the	the	DET
admet-3	160	17	other	other	ADJ
admet-3	160	18	carboxylate	carboxylate	NOUN
admet-3	160	19	in	in	ADP
admet-3	160	20	the	the	DET
admet-3	160	21	side	side	NOUN
admet-3	160	22	chain	chain	NOUN
admet-3	160	23	participates	participate	VERB
admet-3	160	24	in	in	ADP
admet-3	160	25	complex	complex	ADJ
admet-3	160	26	formation	formation	NOUN
admet-3	160	27	with	with	ADP
admet-3	160	28	the	the	DET
admet-3	160	29	zn	zn	PROPN
admet-3	160	30	ion	ion	NOUN
admet-3	160	31	.	.	PUNCT
admet-3	161	1	the	the	DET
admet-3	161	2	third	third	ADJ
admet-3	161	3	binding	bind	VERB
admet-3	161	4	site	site	NOUN
admet-3	161	5	is	be	AUX
admet-3	161	6	represented	represent	VERB
admet-3	161	7	by	by	ADP
admet-3	161	8	ser	ser	NOUN
admet-3	161	9	-	-	PROPN
admet-3	161	10	oh	oh	INTJ
admet-3	161	11	where	where	SCONJ
admet-3	161	12	the	the	DET
admet-3	161	13	c1’=o	c1’=o	PROPN
admet-3	161	14	group	group	NOUN
admet-3	161	15	forms	form	VERB
admet-3	161	16	an	an	DET
admet-3	161	17	h	h	NOUN
admet-3	161	18	-	-	PUNCT
admet-3	161	19	bond	bond	NOUN
admet-3	161	20	.	.	PUNCT
admet-3	162	1	the	the	DET
admet-3	162	2	species	species	NOUN
admet-3	162	3	distribution	distribution	NOUN
admet-3	162	4	revealed	reveal	VERB
admet-3	162	5	in	in	ADP
admet-3	162	6	this	this	DET
admet-3	162	7	study	study	NOUN
admet-3	162	8	explains	explain	VERB
admet-3	162	9	the	the	DET
admet-3	162	10	good	good	ADJ
admet-3	162	11	receptor	receptor	NOUN
admet-3	162	12	binding	bind	VERB
admet-3	162	13	of	of	ADP
admet-3	162	14	lisinopril	lisinopril	NOUN
admet-3	162	15	.	.	PUNCT
admet-3	163	1	references	reference	NOUN
admet-3	163	2	[	[	X
admet-3	163	3	1	1	X
admet-3	163	4	]	]	PUNCT
admet-3	163	5	j.	j.	PROPN
admet-3	163	6	wong	wong	PROPN
admet-3	163	7	,	,	PUNCT
admet-3	163	8	r.a	r.a	PROPN
admet-3	163	9	.	.	PROPN
admet-3	163	10	patel	patel	PROPN
admet-3	163	11	,	,	PUNCT
admet-3	163	12	p.r	p.r	PROPN
admet-3	163	13	.	.	PROPN
admet-3	163	14	kowey	kowey	PROPN
admet-3	163	15	,	,	PUNCT
admet-3	163	16	progress	progress	NOUN
admet-3	163	17	in	in	ADP
admet-3	163	18	cardiovascular	cardiovascular	ADJ
admet-3	163	19	diseases	disease	NOUN
admet-3	163	20	47	47	NUM
admet-3	163	21	(	(	PUNCT
admet-3	163	22	2004	2004	NUM
admet-3	163	23	)	)	PUNCT
admet-3	163	24	116	116	NUM
admet-3	163	25	-	-	SYM
admet-3	163	26	130	130	NUM
admet-3	163	27	.	.	PUNCT
admet-3	164	1	[	[	X
admet-3	164	2	2	2	NUM
admet-3	164	3	]	]	PUNCT
admet-3	164	4	m.	m.	NOUN
admet-3	164	5	harrold	harrold	PROPN
admet-3	164	6	,	,	PUNCT
admet-3	164	7	in	in	ADP
admet-3	164	8	:	:	PUNCT
admet-3	164	9	d.a	d.a	PROPN
admet-3	164	10	.	.	PROPN
admet-3	164	11	williams	williams	PROPN
admet-3	164	12	,	,	PUNCT
admet-3	164	13	t.l	t.l	PROPN
admet-3	164	14	.	.	PUNCT
admet-3	164	15	lemke	lemke	PROPN
admet-3	164	16	(	(	PUNCT
admet-3	164	17	eds	ed	NOUN
admet-3	164	18	)	)	PUNCT
admet-3	164	19	,	,	PUNCT
admet-3	164	20	foye	foye	PROPN
admet-3	164	21	’s	’s	PART
admet-3	164	22	principal	principal	NOUN
admet-3	164	23	of	of	ADP
admet-3	164	24	medicinal	medicinal	ADJ
admet-3	164	25	chemistry	chemistry	NOUN
admet-3	164	26	,	,	PUNCT
admet-3	164	27	5th	5th	ADJ
admet-3	164	28	edn	edn	NOUN
admet-3	164	29	.	.	PUNCT
admet-3	165	1	lippincott	lippincott	PROPN
admet-3	165	2	williams	williams	PROPN
admet-3	165	3	&	&	CCONJ
admet-3	165	4	wilkins	wilkins	PROPN
admet-3	165	5	,	,	PUNCT
admet-3	165	6	philadelphia	philadelphia	PROPN
admet-3	165	7	,	,	PUNCT
admet-3	165	8	2002	2002	NUM
admet-3	165	9	,	,	PUNCT
admet-3	165	10	p.	p.	NOUN
admet-3	165	11	533	533	NUM
admet-3	165	12	.	.	PUNCT
admet-3	166	1	[	[	X
admet-3	166	2	3	3	X
admet-3	166	3	]	]	X
admet-3	166	4	b.	b.	NOUN
admet-3	166	5	beermann	beermann	PROPN
admet-3	166	6	,	,	PUNCT
admet-3	166	7	american	american	ADJ
admet-3	166	8	journal	journal	NOUN
admet-3	166	9	of	of	ADP
admet-3	166	10	medicine	medicine	NOUN
admet-3	166	11	85	85	NUM
admet-3	166	12	(	(	PUNCT
admet-3	166	13	3b	3b	NUM
admet-3	166	14	)	)	PUNCT
admet-3	166	15	(	(	PUNCT
admet-3	166	16	1988	1988	NUM
admet-3	166	17	)	)	PUNCT
admet-3	166	18	25	25	NUM
admet-3	166	19	-	-	SYM
admet-3	166	20	30	30	NUM
admet-3	166	21	.	.	PUNCT
admet-3	167	1	[	[	X
admet-3	167	2	4	4	NUM
admet-3	167	3	]	]	X
admet-3	167	4	d.j	d.j	PROPN
admet-3	167	5	.	.	PROPN
admet-3	167	6	eveson	eveson	PROPN
admet-3	167	7	,	,	PUNCT
admet-3	167	8	t.g	t.g	PROPN
admet-3	167	9	.	.	PROPN
admet-3	167	10	robinson	robinson	PROPN
admet-3	167	11	,	,	PUNCT
admet-3	167	12	j.f	j.f	PROPN
admet-3	167	13	.	.	PROPN
admet-3	167	14	potter	potter	PROPN
admet-3	167	15	,	,	PUNCT
admet-3	167	16	american	american	ADJ
admet-3	167	17	journal	journal	NOUN
admet-3	167	18	of	of	ADP
admet-3	167	19	hypertension	hypertension	NOUN
admet-3	167	20	20	20	NUM
admet-3	167	21	(	(	PUNCT
admet-3	167	22	2007	2007	NUM
admet-3	167	23	)	)	PUNCT
admet-3	167	24	270	270	NUM
admet-3	167	25	-	-	SYM
admet-3	167	26	277	277	NUM
admet-3	167	27	.	.	PUNCT
admet-3	168	1	[	[	X
admet-3	168	2	5	5	NUM
admet-3	168	3	]	]	X
admet-3	168	4	n.k	n.k	PROPN
admet-3	168	5	.	.	PROPN
admet-3	168	6	hollenberg	hollenberg	PROPN
admet-3	168	7	,	,	PUNCT
admet-3	168	8	d.a	d.a	PROPN
admet-3	168	9	.	.	PROPN
admet-3	168	10	anzalone	anzalone	PROPN
admet-3	168	11	,	,	PUNCT
admet-3	168	12	b.	b.	PROPN
admet-3	168	13	falkner	falkner	PROPN
admet-3	168	14	,	,	PUNCT
admet-3	168	15	n.d.l	n.d.l	PROPN
admet-3	168	16	.	.	PUNCT
admet-3	168	17	fisher	fisher	PROPN
admet-3	168	18	,	,	PUNCT
admet-3	168	19	p.n	p.n	PROPN
admet-3	168	20	.	.	PROPN
admet-3	168	21	hopkins	hopkins	PROPN
admet-3	168	22	,	,	PUNCT
admet-3	168	23	w.	w.	PROPN
admet-3	168	24	hsueh	hsueh	PROPN
admet-3	168	25	,	,	PUNCT
admet-3	168	26	h.	h.	PROPN
admet-3	168	27	hutchinson	hutchinson	PROPN
admet-3	168	28	,	,	PUNCT
admet-3	168	29	r.m	r.m	PROPN
admet-3	168	30	.	.	PROPN
admet-3	168	31	krauss	krauss	PROPN
admet-3	168	32	,	,	PUNCT
admet-3	168	33	d.a	d.a	PROPN
admet-3	168	34	.	.	PROPN
admet-3	168	35	price	price	NOUN
admet-3	168	36	,	,	PUNCT
admet-3	168	37	p.	p.	NOUN
admet-3	168	38	raskin	raskin	PROPN
admet-3	168	39	,	,	PUNCT
admet-3	168	40	g.m	g.m	PROPN
admet-3	168	41	.	.	PROPN
admet-3	168	42	reaven	reaven	PROPN
admet-3	168	43	,	,	PUNCT
admet-3	168	44	american	american	ADJ
admet-3	168	45	journal	journal	PROPN
admet-3	168	46	of	of	ADP
admet-3	168	47	hypertension	hypertension	NOUN
admet-3	168	48	14	14	NUM
admet-3	168	49	(	(	PUNCT
admet-3	168	50	2001	2001	NUM
admet-3	168	51	)	)	PUNCT
admet-3	168	52	218223	218223	NUM
admet-3	168	53	.	.	PUNCT
admet-3	169	1	krisztina	krisztina	AUX
admet-3	169	2	takács	takács	VERB
admet-3	169	3	novák	novák	PROPN
admet-3	169	4	et	et	PROPN
admet-3	169	5	al	al	PROPN
admet-3	169	6	.	.	PROPN
admet-3	169	7	admet	admet	PROPN
admet-3	169	8	&	&	CCONJ
admet-3	169	9	dmpk	dmpk	PROPN
admet-3	169	10	1(2	1(2	NUM
admet-3	169	11	)	)	PUNCT
admet-3	169	12	(	(	PUNCT
admet-3	169	13	2013	2013	NUM
admet-3	169	14	)	)	PUNCT
admet-3	169	15	6	6	NUM
admet-3	169	16	-	-	SYM
admet-3	169	17	16	16	NUM
admet-3	169	18	16	16	NUM
admet-3	170	1	[	[	X
admet-3	170	2	6	6	NUM
admet-3	170	3	]	]	SYM
admet-3	170	4	c.m	c.m	PROPN
admet-3	170	5	.	.	PROPN
admet-3	170	6	white	white	PROPN
admet-3	170	7	,	,	PUNCT
admet-3	170	8	pharmacotherapy	pharmacotherapy	NOUN
admet-3	170	9	18	18	NUM
admet-3	170	10	(	(	PUNCT
admet-3	170	11	1998	1998	NUM
admet-3	170	12	)	)	PUNCT
admet-3	170	13	588	588	NUM
admet-3	170	14	-	-	SYM
admet-3	170	15	599	599	NUM
admet-3	170	16	.	.	PUNCT
admet-3	171	1	[	[	X
admet-3	171	2	7	7	X
admet-3	171	3	]	]	X
admet-3	171	4	k.l	k.l	PROPN
admet-3	171	5	.	.	PROPN
admet-3	171	6	goa	goa	PROPN
admet-3	171	7	,	,	PUNCT
admet-3	171	8	j.a	j.a	PROPN
admet-3	171	9	.	.	PROPN
admet-3	171	10	balfour	balfour	PROPN
admet-3	171	11	,	,	PUNCT
admet-3	171	12	g.	g.	PROPN
admet-3	171	13	zuanetti	zuanetti	PROPN
admet-3	171	14	,	,	PUNCT
admet-3	171	15	drugs	drug	NOUN
admet-3	171	16	52	52	NUM
admet-3	171	17	(	(	PUNCT
admet-3	171	18	1996	1996	NUM
admet-3	171	19	)	)	PUNCT
admet-3	171	20	564	564	NUM
admet-3	171	21	-	-	SYM
admet-3	171	22	588	588	NUM
admet-3	171	23	.	.	PUNCT
admet-3	172	1	[	[	X
admet-3	172	2	8	8	NUM
admet-3	172	3	]	]	X
admet-3	172	4	c.	c.	NOUN
admet-3	172	5	bennion	bennion	NOUN
admet-3	172	6	,	,	PUNCT
admet-3	172	7	r.c	r.c	PROPN
admet-3	172	8	.	.	PROPN
admet-3	172	9	brown	brown	PROPN
admet-3	172	10	,	,	PUNCT
admet-3	172	11	a.r	a.r	PROPN
admet-3	172	12	.	.	PROPN
admet-3	172	13	cook	cook	PROPN
admet-3	172	14	,	,	PUNCT
admet-3	172	15	c.n	c.n	PROPN
admet-3	172	16	.	.	PROPN
admet-3	172	17	manners	manner	NOUN
admet-3	172	18	,	,	PUNCT
admet-3	172	19	d.w	d.w	PROPN
admet-3	172	20	.	.	PROPN
admet-3	172	21	payling	payling	PROPN
admet-3	172	22	,	,	PUNCT
admet-3	172	23	d.h	d.h	PROPN
admet-3	172	24	.	.	PROPN
admet-3	172	25	robinson	robinson	PROPN
admet-3	172	26	,	,	PUNCT
admet-3	172	27	journal	journal	NOUN
admet-3	172	28	of	of	ADP
admet-3	172	29	medicinal	medicinal	ADJ
admet-3	172	30	chemistry	chemistry	NOUN
admet-3	172	31	34	34	NUM
admet-3	172	32	(	(	PUNCT
admet-3	172	33	1991	1991	NUM
admet-3	172	34	)	)	PUNCT
admet-3	172	35	439	439	NUM
admet-3	172	36	-	-	SYM
admet-3	172	37	447	447	NUM
admet-3	172	38	.	.	PUNCT
admet-3	173	1	[	[	X
admet-3	173	2	9	9	NUM
admet-3	173	3	]	]	X
admet-3	173	4	d.p	d.p	PROPN
admet-3	173	5	.	.	PROPN
admet-3	173	6	ip	ip	PROPN
admet-3	173	7	,	,	PUNCT
admet-3	173	8	j.d	j.d	PROPN
admet-3	173	9	.	.	PROPN
admet-3	173	10	demarco	demarco	PROPN
admet-3	173	11	,	,	PUNCT
admet-3	173	12	m.a	m.a	PROPN
admet-3	173	13	.	.	PROPN
admet-3	173	14	brooks	brooks	PROPN
admet-3	173	15	,	,	PUNCT
admet-3	173	16	analytical	analytical	ADJ
admet-3	173	17	profiles	profile	NOUN
admet-3	173	18	of	of	ADP
admet-3	173	19	drug	drug	NOUN
admet-3	173	20	substances	substance	NOUN
admet-3	173	21	21	21	NUM
admet-3	173	22	(	(	PUNCT
admet-3	173	23	1992	1992	NUM
admet-3	173	24	)	)	PUNCT
admet-3	173	25	233	233	NUM
admet-3	173	26	-	-	SYM
admet-3	173	27	276	276	NUM
admet-3	173	28	.	.	PUNCT
admet-3	174	1	[	[	X
admet-3	174	2	10	10	NUM
admet-3	174	3	]	]	X
admet-3	174	4	e.b	e.b	PROPN
admet-3	174	5	.	.	PUNCT
admet-3	174	6	gonzalez	gonzalez	PROPN
admet-3	174	7	,	,	PUNCT
admet-3	174	8	e.	e.	PROPN
admet-3	174	9	farkas	farkas	PROPN
admet-3	174	10	,	,	PUNCT
admet-3	174	11	a.a	a.a	PROPN
admet-3	174	12	.	.	PROPN
admet-3	174	13	soudi	soudi	PROPN
admet-3	174	14	,	,	PUNCT
admet-3	174	15	t.	t.	PROPN
admet-3	174	16	tan	tan	PROPN
admet-3	174	17	,	,	PUNCT
admet-3	174	18	a.i	a.i	PROPN
admet-3	174	19	.	.	PROPN
admet-3	174	20	yanovsky	yanovsky	PROPN
admet-3	174	21	,	,	PUNCT
admet-3	174	22	k.b	k.b	PROPN
admet-3	174	23	.	.	PROPN
admet-3	174	24	nolan	nolan	PROPN
admet-3	174	25	,	,	PUNCT
admet-3	174	26	journal	journal	NOUN
admet-3	174	27	of	of	ADP
admet-3	174	28	chemical	chemical	PROPN
admet-3	174	29	society	society	PROPN
admet-3	174	30	dalton	dalton	PROPN
admet-3	174	31	transactions	transaction	NOUN
admet-3	174	32	(	(	PUNCT
admet-3	174	33	1997	1997	NUM
admet-3	174	34	)	)	PUNCT
admet-3	174	35	2377	2377	NUM
admet-3	174	36	-	-	SYM
admet-3	174	37	2379	2379	NUM
admet-3	174	38	.	.	PUNCT
admet-3	175	1	[	[	X
admet-3	175	2	11	11	NUM
admet-3	175	3	]	]	X
admet-3	175	4	european	european	ADJ
admet-3	175	5	pharmacopoeia	pharmacopoeia	PROPN
admet-3	175	6	7.0	7.0	NUM
admet-3	175	7	,	,	PUNCT
admet-3	175	8	strasbourg	strasbourg	NOUN
admet-3	175	9	.	.	PUNCT
admet-3	176	1	[	[	X
admet-3	176	2	12	12	NUM
admet-3	176	3	]	]	X
admet-3	176	4	n.	n.	PROPN
admet-3	176	5	rahman	rahman	PROPN
admet-3	176	6	,	,	PUNCT
admet-3	176	7	n.	n.	PROPN
admet-3	176	8	anwar	anwar	PROPN
admet-3	176	9	,	,	PUNCT
admet-3	176	10	m.	m.	PROPN
admet-3	176	11	kashif	kashif	PROPN
admet-3	176	12	,	,	PUNCT
admet-3	176	13	il	il	PROPN
admet-3	176	14	farmaco	farmaco	PROPN
admet-3	176	15	60	60	NUM
admet-3	176	16	(	(	PUNCT
admet-3	176	17	2005	2005	NUM
admet-3	176	18	)	)	PUNCT
admet-3	176	19	605	605	NUM
admet-3	176	20	-	-	SYM
admet-3	176	21	611	611	NUM
admet-3	176	22	.	.	PUNCT
admet-3	177	1	[	[	X
admet-3	177	2	13	13	NUM
admet-3	177	3	]	]	X
admet-3	177	4	c.a	c.a	PROPN
admet-3	177	5	.	.	PROPN
admet-3	177	6	beasley	beasley	PROPN
admet-3	177	7	,	,	PUNCT
admet-3	177	8	j.	j.	PROPN
admet-3	177	9	shaw	shaw	PROPN
admet-3	177	10	,	,	PUNCT
admet-3	177	11	z.	z.	PROPN
admet-3	177	12	zhao	zhao	PROPN
admet-3	177	13	,	,	PUNCT
admet-3	177	14	r.a	r.a	PROPN
admet-3	177	15	.	.	PROPN
admet-3	177	16	reed	reed	PROPN
admet-3	177	17	,	,	PUNCT
admet-3	177	18	journal	journal	NOUN
admet-3	177	19	of	of	ADP
admet-3	177	20	pharmaceutical	pharmaceutical	NOUN
admet-3	177	21	and	and	CCONJ
admet-3	177	22	biomedical	biomedical	ADJ
admet-3	177	23	analysis	analysis	NOUN
admet-3	177	24	37	37	NUM
admet-3	177	25	(	(	PUNCT
admet-3	177	26	2005	2005	NUM
admet-3	177	27	)	)	PUNCT
admet-3	177	28	559	559	NUM
admet-3	177	29	-	-	SYM
admet-3	177	30	567	567	NUM
admet-3	177	31	.	.	PUNCT
admet-3	178	1	[	[	X
admet-3	178	2	14	14	NUM
admet-3	178	3	]	]	X
admet-3	178	4	a.	a.	PROPN
admet-3	178	5	el	el	NOUN
admet-3	178	6	-	-	NOUN
admet-3	178	7	gindy	gindy	NOUN
admet-3	178	8	,	,	PUNCT
admet-3	178	9	a.	a.	NOUN
admet-3	178	10	ashour	ashour	PROPN
admet-3	178	11	,	,	PUNCT
admet-3	178	12	l.	l.	PROPN
admet-3	178	13	abdel	abdel	PROPN
admet-3	178	14	-	-	PUNCT
admet-3	178	15	fattah	fattah	PROPN
admet-3	178	16	,	,	PUNCT
admet-3	178	17	m.m	m.m	PROPN
admet-3	178	18	.	.	PROPN
admet-3	178	19	shabana	shabana	PROPN
admet-3	178	20	,	,	PUNCT
admet-3	178	21	journal	journal	NOUN
admet-3	178	22	of	of	ADP
admet-3	178	23	pharmaceutical	pharmaceutical	NOUN
admet-3	178	24	and	and	CCONJ
admet-3	178	25	biomedical	biomedical	ADJ
admet-3	178	26	analysis	analysis	NOUN
admet-3	178	27	25	25	NUM
admet-3	178	28	(	(	PUNCT
admet-3	178	29	2001	2001	NUM
admet-3	178	30	)	)	PUNCT
admet-3	178	31	923	923	NUM
admet-3	178	32	-	-	NUM
admet-3	178	33	931	931	NUM
admet-3	178	34	.	.	PUNCT
admet-3	179	1	[	[	X
admet-3	179	2	15	15	NUM
admet-3	179	3	]	]	X
admet-3	179	4	s.	s.	PROPN
admet-3	179	5	hillaert	hillaert	PROPN
admet-3	179	6	,	,	PUNCT
admet-3	179	7	w.	w.	PROPN
admet-3	179	8	van	van	PROPN
admet-3	179	9	den	den	PROPN
admet-3	179	10	bossche	bossche	PROPN
admet-3	179	11	,	,	PUNCT
admet-3	179	12	journal	journal	NOUN
admet-3	179	13	of	of	ADP
admet-3	179	14	pharmaceutical	pharmaceutical	NOUN
admet-3	179	15	and	and	CCONJ
admet-3	179	16	biomedical	biomedical	ADJ
admet-3	179	17	analysis	analysis	NOUN
admet-3	179	18	25	25	NUM
admet-3	179	19	(	(	PUNCT
admet-3	179	20	2001	2001	NUM
admet-3	179	21	)	)	PUNCT
admet-3	179	22	775783	775783	NUM
admet-3	179	23	.	.	PUNCT
admet-3	180	1	[	[	X
admet-3	180	2	16	16	NUM
admet-3	180	3	]	]	X
admet-3	180	4	b.	b.	PROPN
admet-3	180	5	noszál	noszál	PROPN
admet-3	180	6	,	,	PUNCT
admet-3	180	7	in	in	ADP
admet-3	180	8	:	:	PUNCT
admet-3	180	9	k.	k.	PROPN
admet-3	180	10	burger	burger	PROPN
admet-3	180	11	(	(	PUNCT
admet-3	180	12	ed	ed	NOUN
admet-3	180	13	.	.	PUNCT
admet-3	180	14	)	)	PUNCT
admet-3	180	15	,	,	PUNCT
admet-3	180	16	biocoordination	biocoordination	NOUN
admet-3	180	17	chemistry	chemistry	NOUN
admet-3	180	18	,	,	PUNCT
admet-3	180	19	coordination	coordination	NOUN
admet-3	180	20	equilibria	equilibrium	NOUN
admet-3	180	21	in	in	ADP
admet-3	180	22	biologically	biologically	ADV
admet-3	180	23	active	active	ADJ
admet-3	180	24	systems	system	NOUN
admet-3	180	25	.	.	PUNCT
admet-3	181	1	ellis	ellis	PROPN
admet-3	181	2	horwood	horwood	PROPN
admet-3	181	3	,	,	PUNCT
admet-3	181	4	chichester	chichester	PROPN
admet-3	181	5	,	,	PUNCT
admet-3	181	6	1990	1990	NUM
admet-3	181	7	,	,	PUNCT
admet-3	181	8	p.	p.	NOUN
admet-3	181	9	18	18	NUM
admet-3	181	10	.	.	PUNCT
admet-3	182	1	[	[	X
admet-3	182	2	17	17	NUM
admet-3	182	3	]	]	PUNCT
admet-3	182	4	k.	k.	PROPN
admet-3	182	5	takács	takács	PROPN
admet-3	182	6	-	-	PUNCT
admet-3	182	7	novák	novák	PROPN
admet-3	182	8	,	,	PUNCT
admet-3	182	9	b.	b.	PROPN
admet-3	182	10	noszál	noszál	PROPN
admet-3	182	11	,	,	PUNCT
admet-3	182	12	m.	m.	NOUN
admet-3	182	13	tőkés	tőkés	NOUN
admet-3	182	14	-	-	PUNCT
admet-3	182	15	kövesdi	kövesdi	PROPN
admet-3	182	16	,	,	PUNCT
admet-3	182	17	gy	gy	NOUN
admet-3	182	18	.	.	PROPN
admet-3	182	19	szász	szász	PROPN
admet-3	182	20	,	,	PUNCT
admet-3	182	21	journal	journal	NOUN
admet-3	182	22	of	of	ADP
admet-3	182	23	pharmacy	pharmacy	NOUN
admet-3	182	24	and	and	CCONJ
admet-3	182	25	pharmacology	pharmacology	NOUN
admet-3	182	26	47	47	NUM
admet-3	182	27	(	(	PUNCT
admet-3	182	28	1995	1995	NUM
admet-3	182	29	)	)	PUNCT
admet-3	182	30	431	431	NUM
admet-3	182	31	-	-	SYM
admet-3	182	32	435	435	NUM
admet-3	182	33	.	.	PUNCT
admet-3	183	1	[	[	X
admet-3	183	2	18	18	NUM
admet-3	183	3	]	]	PUNCT
admet-3	183	4	a.	a.	NOUN
admet-3	183	5	avdeef	avdeef	PROPN
admet-3	183	6	,	,	PUNCT
admet-3	183	7	j.j	j.j	PROPN
admet-3	183	8	.	.	PROPN
admet-3	183	9	bucher	bucher	PROPN
admet-3	183	10	,	,	PUNCT
admet-3	183	11	analytical	analytical	ADJ
admet-3	183	12	chemistry	chemistry	NOUN
admet-3	183	13	50	50	NUM
admet-3	183	14	(	(	PUNCT
admet-3	183	15	1978	1978	NUM
admet-3	183	16	)	)	PUNCT
admet-3	183	17	2137	2137	NUM
admet-3	183	18	-	-	SYM
admet-3	183	19	2142	2142	NUM
admet-3	183	20	.	.	PUNCT
admet-3	184	1	[	[	X
admet-3	184	2	19	19	NUM
admet-3	184	3	]	]	PUNCT
admet-3	184	4	k.	k.	PROPN
admet-3	184	5	takács	takács	PROPN
admet-3	184	6	-	-	PUNCT
admet-3	184	7	novák	novák	PROPN
admet-3	184	8	,	,	PUNCT
admet-3	184	9	k.j	k.j	PROPN
admet-3	184	10	.	.	PROPN
admet-3	184	11	box	box	PROPN
admet-3	184	12	,	,	PUNCT
admet-3	184	13	a.	a.	NOUN
admet-3	184	14	avdeef	avdeef	PROPN
admet-3	184	15	,	,	PUNCT
admet-3	184	16	international	international	ADJ
admet-3	184	17	journal	journal	NOUN
admet-3	184	18	of	of	ADP
admet-3	184	19	pharmaceutics	pharmaceutic	NOUN
admet-3	184	20	151	151	NUM
admet-3	184	21	(	(	PUNCT
admet-3	184	22	1997	1997	NUM
admet-3	184	23	)	)	PUNCT
admet-3	184	24	235	235	NUM
admet-3	184	25	-	-	SYM
admet-3	184	26	248	248	NUM
admet-3	184	27	.	.	PUNCT
admet-3	185	1	[	[	X
admet-3	185	2	20	20	NUM
admet-3	185	3	]	]	PUNCT
admet-3	185	4	k.	k.	PROPN
admet-3	185	5	deák	deák	PROPN
admet-3	185	6	,	,	PUNCT
admet-3	185	7	k.	k.	PROPN
admet-3	185	8	takács	takács	PROPN
admet-3	185	9	-	-	PUNCT
admet-3	185	10	novák	novák	PROPN
admet-3	185	11	,	,	PUNCT
admet-3	185	12	k.	k.	PROPN
admet-3	185	13	tihanyi	tihanyi	PROPN
admet-3	185	14	,	,	PUNCT
admet-3	185	15	b.	b.	PROPN
admet-3	185	16	noszál	noszál	PROPN
admet-3	185	17	,	,	PUNCT
admet-3	185	18	medicinal	medicinal	ADJ
admet-3	185	19	chemistry	chemistry	NOUN
admet-3	185	20	2	2	NUM
admet-3	185	21	(	(	PUNCT
admet-3	185	22	2006	2006	NUM
admet-3	185	23	)	)	PUNCT
admet-3	185	24	385	385	NUM
admet-3	185	25	-	-	SYM
admet-3	185	26	389	389	NUM
admet-3	185	27	.	.	PUNCT
admet-3	186	1	[	[	X
admet-3	186	2	21	21	NUM
admet-3	186	3	]	]	X
admet-3	186	4	z.	z.	PROPN
admet-3	186	5	szakács	szakács	PROPN
admet-3	186	6	,	,	PUNCT
admet-3	186	7	g.	g.	PROPN
admet-3	186	8	hägele	hägele	PROPN
admet-3	186	9	,	,	PUNCT
admet-3	186	10	r.	r.	PROPN
admet-3	186	11	tyka	tyka	PROPN
admet-3	186	12	,	,	PUNCT
admet-3	186	13	analytica	analytica	PROPN
admet-3	186	14	chimica	chimica	PROPN
admet-3	186	15	acta	acta	PROPN
admet-3	186	16	522	522	NUM
admet-3	186	17	(	(	PUNCT
admet-3	186	18	2004	2004	NUM
admet-3	186	19	)	)	PUNCT
admet-3	186	20	247	247	NUM
admet-3	186	21	-	-	SYM
admet-3	186	22	258	258	NUM
admet-3	186	23	.	.	PUNCT
admet-3	187	1	[	[	X
admet-3	187	2	22	22	NUM
admet-3	187	3	]	]	PUNCT
admet-3	187	4	z.	z.	PROPN
admet-3	187	5	szakács	szakács	PROPN
admet-3	187	6	,	,	PUNCT
admet-3	187	7	sz	sz	PROPN
admet-3	187	8	.	.	PROPN
admet-3	187	9	béni	béni	PROPN
admet-3	187	10	,	,	PUNCT
admet-3	187	11	z.	z.	PROPN
admet-3	187	12	varga	varga	PROPN
admet-3	187	13	,	,	PUNCT
admet-3	187	14	l.	l.	PROPN
admet-3	187	15	örfi	örfi	PROPN
admet-3	187	16	,	,	PUNCT
admet-3	187	17	gy	gy	PROPN
admet-3	187	18	.	.	PROPN
admet-3	187	19	kéri	kéri	PROPN
admet-3	187	20	,	,	PUNCT
admet-3	187	21	b.	b.	PROPN
admet-3	187	22	noszál	noszál	PROPN
admet-3	187	23	,	,	PUNCT
admet-3	187	24	journal	journal	NOUN
admet-3	187	25	of	of	ADP
admet-3	187	26	medicinal	medicinal	ADJ
admet-3	187	27	chemistry	chemistry	NOUN
admet-3	187	28	48	48	NUM
admet-3	187	29	(	(	PUNCT
admet-3	187	30	2005	2005	NUM
admet-3	187	31	)	)	PUNCT
admet-3	187	32	249	249	NUM
admet-3	187	33	-	-	SYM
admet-3	187	34	255	255	NUM
admet-3	187	35	.	.	PUNCT
admet-3	188	1	[	[	X
admet-3	188	2	23	23	NUM
admet-3	188	3	]	]	PUNCT
admet-3	188	4	m.	m.	NOUN
admet-3	188	5	boros	boros	PROPN
admet-3	188	6	,	,	PUNCT
admet-3	188	7	j.	j.	PROPN
admet-3	188	8	kökösi	kökösi	PROPN
admet-3	188	9	,	,	PUNCT
admet-3	188	10	j.	j.	PROPN
admet-3	188	11	vámos	vámos	PROPN
admet-3	188	12	,	,	PUNCT
admet-3	188	13	b.	b.	PROPN
admet-3	188	14	noszál	noszál	PROPN
admet-3	188	15	,	,	PUNCT
admet-3	188	16	journal	journal	NOUN
admet-3	188	17	of	of	ADP
admet-3	188	18	pharmaceutical	pharmaceutical	NOUN
admet-3	188	19	and	and	CCONJ
admet-3	188	20	biomedical	biomedical	ADJ
admet-3	188	21	analysis	analysis	NOUN
admet-3	188	22	43	43	NUM
admet-3	188	23	(	(	PUNCT
admet-3	188	24	2007	2007	NUM
admet-3	188	25	)	)	PUNCT
admet-3	188	26	1306	1306	NUM
admet-3	188	27	-	-	SYM
admet-3	188	28	1314	1314	NUM
admet-3	188	29	.	.	PUNCT
admet-3	189	1	[	[	X
admet-3	189	2	24	24	NUM
admet-3	189	3	]	]	PUNCT
admet-3	189	4	m.	m.	NOUN
admet-3	189	5	kyvala	kyvala	PROPN
admet-3	189	6	,	,	PUNCT
admet-3	189	7	i.	i.	PROPN
admet-3	189	8	lukes	lukes	PROPN
admet-3	189	9	,	,	PUNCT
admet-3	189	10	(	(	PUNCT
admet-3	189	11	1995	1995	NUM
admet-3	189	12	)	)	PUNCT
admet-3	189	13	opium	opium	NOUN
admet-3	189	14	computer	computer	NOUN
admet-3	189	15	program	program	NOUN
admet-3	189	16	,	,	PUNCT
admet-3	189	17	http://www.natur.cuni.cz/~kyvala/opium.html	http://www.natur.cuni.cz/~kyvala/opium.html	PROPN
admet-3	190	1	[	[	X
admet-3	190	2	25	25	NUM
admet-3	190	3	]	]	PUNCT
admet-3	190	4	a.	a.	NOUN
admet-3	190	5	avdeef	avdeef	PROPN
admet-3	190	6	,	,	PUNCT
admet-3	190	7	j.e.a	j.e.a	PROPN
admet-3	190	8	.	.	PUNCT
admet-3	190	9	comer	comer	PROPN
admet-3	190	10	,	,	PUNCT
admet-3	190	11	s.j	s.j	PROPN
admet-3	190	12	.	.	PROPN
admet-3	190	13	thomson	thomson	PROPN
admet-3	190	14	,	,	PUNCT
admet-3	190	15	analytical	analytical	ADJ
admet-3	190	16	chemistry	chemistry	NOUN
admet-3	190	17	65	65	NUM
admet-3	190	18	(	(	PUNCT
admet-3	190	19	1993	1993	NUM
admet-3	190	20	)	)	PUNCT
admet-3	190	21	42	42	NUM
admet-3	190	22	-	-	SYM
admet-3	190	23	49	49	NUM
admet-3	190	24	.	.	PUNCT
admet-3	191	1	[	[	X
admet-3	191	2	26	26	NUM
admet-3	191	3	]	]	PUNCT
admet-3	191	4	z.	z.	PROPN
admet-3	191	5	szakács	szakács	PROPN
admet-3	191	6	,	,	PUNCT
admet-3	191	7	m.	m.	NOUN
admet-3	191	8	kraszni	kraszni	PROPN
admet-3	191	9	,	,	PUNCT
admet-3	191	10	b.	b.	PROPN
admet-3	191	11	noszál	noszál	PROPN
admet-3	191	12	,	,	PUNCT
admet-3	191	13	analytical	analytical	ADJ
admet-3	191	14	and	and	CCONJ
admet-3	191	15	bioanalytical	bioanalytical	ADJ
admet-3	191	16	chemistry	chemistry	NOUN
admet-3	191	17	378	378	NUM
admet-3	191	18	(	(	PUNCT
admet-3	191	19	2004	2004	NUM
admet-3	191	20	)	)	PUNCT
admet-3	191	21	1428	1428	NUM
admet-3	191	22	-	-	SYM
admet-3	191	23	1448	1448	NUM
admet-3	191	24	.	.	PUNCT
admet-3	192	1	[	[	X
admet-3	192	2	27	27	NUM
admet-3	192	3	]	]	X
admet-3	192	4	b.	b.	PROPN
admet-3	192	5	noszál	noszál	PROPN
admet-3	192	6	,	,	PUNCT
admet-3	192	7	z.	z.	PROPN
admet-3	192	8	szakács	szakács	PROPN
admet-3	192	9	,	,	PUNCT
admet-3	192	10	journal	journal	NOUN
admet-3	192	11	of	of	ADP
admet-3	192	12	physical	physical	ADJ
admet-3	192	13	chemistry	chemistry	NOUN
admet-3	192	14	b	b	PROPN
admet-3	192	15	107	107	NUM
admet-3	192	16	(	(	PUNCT
admet-3	192	17	2003	2003	NUM
admet-3	192	18	)	)	PUNCT
admet-3	192	19	5074	5074	NUM
admet-3	192	20	-	-	SYM
admet-3	192	21	5080	5080	NUM
admet-3	192	22	.	.	PUNCT
admet-3	193	1	[	[	X
admet-3	193	2	28	28	NUM
admet-3	193	3	]	]	X
admet-3	193	4	v.a	v.a	PROPN
admet-3	193	5	.	.	PROPN
admet-3	193	6	moore	moore	PROPN
admet-3	193	7	,	,	PUNCT
admet-3	193	8	w.j	w.j	PROPN
admet-3	193	9	.	.	PROPN
admet-3	193	10	irwin	irwin	PROPN
admet-3	193	11	,	,	PUNCT
admet-3	193	12	p.	p.	PROPN
admet-3	193	13	timmins	timmins	PROPN
admet-3	193	14	,	,	PUNCT
admet-3	193	15	p.a	p.a	PROPN
admet-3	193	16	.	.	PROPN
admet-3	193	17	lambert	lambert	PROPN
admet-3	193	18	,	,	PUNCT
admet-3	193	19	s.	s.	PROPN
admet-3	193	20	chong	chong	PROPN
admet-3	193	21	,	,	PUNCT
admet-3	193	22	s.a	s.a	PROPN
admet-3	193	23	.	.	PROPN
admet-3	193	24	dando	dando	PROPN
admet-3	193	25	,	,	PUNCT
admet-3	193	26	r.a	r.a	PROPN
admet-3	193	27	.	.	PROPN
admet-3	193	28	morrison	morrison	PROPN
admet-3	193	29	,	,	PUNCT
admet-3	193	30	international	international	ADJ
admet-3	193	31	journal	journal	NOUN
admet-3	193	32	of	of	ADP
admet-3	193	33	pharmaceutics	pharmaceutic	NOUN
admet-3	193	34	210	210	NUM
admet-3	193	35	(	(	PUNCT
admet-3	193	36	2000	2000	NUM
admet-3	193	37	)	)	PUNCT
admet-3	193	38	29	29	NUM
admet-3	193	39	-	-	SYM
admet-3	193	40	44	44	NUM
admet-3	193	41	.	.	PUNCT
admet-3	194	1	©	©	PROPN
admet-3	194	2	2013	2013	NUM
admet-3	194	3	by	by	ADP
admet-3	194	4	the	the	DET
admet-3	194	5	authors	author	NOUN
admet-3	194	6	;	;	PUNCT
admet-3	194	7	licensee	licensee	PROPN
admet-3	194	8	iapc	iapc	PROPN
admet-3	194	9	,	,	PUNCT
admet-3	194	10	zagreb	zagreb	PROPN
admet-3	194	11	,	,	PUNCT
admet-3	194	12	croatia	croatia	PROPN
admet-3	194	13	.	.	PUNCT
admet-3	195	1	this	this	DET
admet-3	195	2	article	article	NOUN
admet-3	195	3	is	be	AUX
admet-3	195	4	an	an	DET
admet-3	195	5	open	open	ADJ
admet-3	195	6	-	-	PUNCT
admet-3	195	7	access	access	NOUN
admet-3	195	8	article	article	NOUN
admet-3	195	9	distributed	distribute	VERB
admet-3	195	10	under	under	ADP
admet-3	195	11	the	the	DET
admet-3	195	12	terms	term	NOUN
admet-3	195	13	and	and	CCONJ
admet-3	195	14	conditions	condition	NOUN
admet-3	195	15	of	of	ADP
admet-3	195	16	the	the	DET
admet-3	195	17	creative	creative	ADJ
admet-3	195	18	commons	common	NOUN
admet-3	195	19	attribution	attribution	NOUN
admet-3	195	20	license	license	NOUN
admet-3	195	21	(	(	PUNCT
admet-3	195	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-3	195	23	)	)	PUNCT
admet-3	195	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN