id	sid	tid	token	lemma	pos
admet-3091	1	1	poly(lactic	poly(lactic	PROPN
admet-3091	1	2	-	-	PUNCT
admet-3091	1	3	co	co	NOUN
admet-3091	1	4	-	-	ADJ
admet-3091	1	5	glycolic	glycolic	ADJ
admet-3091	1	6	acid	acid	NOUN
admet-3091	1	7	)	)	PUNCT
admet-3091	1	8	nanoparticles	nanoparticle	NOUN
admet-3091	1	9	and	and	CCONJ
admet-3091	1	10	microparticles	microparticle	NOUN
admet-3091	1	11	for	for	ADP
admet-3091	1	12	peptide	peptide	ADJ
admet-3091	1	13	delivery	delivery	NOUN
admet-3091	1	14	:	:	PUNCT
admet-3091	1	15	release	release	NOUN
admet-3091	1	16	mechanisms	mechanism	NOUN
admet-3091	1	17	and	and	CCONJ
admet-3091	1	18	controlling	control	VERB
admet-3091	1	19	factors	factor	NOUN
admet-3091	1	20	doi	doi	NOUN
admet-3091	1	21	:	:	PUNCT
admet-3091	1	22	http://doi.org/10.5599/admet.3091	http://doi.org/10.5599/admet.3091	NUM
admet-3091	1	23	1	1	NUM
admet-3091	1	24	admet	admet	X
admet-3091	1	25	&	&	CCONJ
admet-3091	1	26	dmpk	dmpk	PROPN
admet-3091	1	27	00(0	00(0	PROPN
admet-3091	1	28	)	)	PUNCT
admet-3091	1	29	(	(	PUNCT
admet-3091	1	30	2025	2025	NUM
admet-3091	1	31	)	)	PUNCT
admet-3091	1	32	3091	3091	NUM
admet-3091	1	33	;	;	PUNCT
admet-3091	1	34	doi	doi	NOUN
admet-3091	1	35	:	:	PUNCT
admet-3091	1	36	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	1	37	open	open	ADJ
admet-3091	1	38	access	access	NOUN
admet-3091	1	39	:	:	PUNCT
admet-3091	1	40	issn	issn	PROPN
admet-3091	1	41	:	:	PUNCT
admet-3091	1	42	1848	1848	NUM
admet-3091	1	43	-	-	SYM
admet-3091	1	44	7718	7718	NUM
admet-3091	2	1	https://pub.iapchem.org/ojs/index.php/admet	https://pub.iapchem.org/ojs/index.php/admet	NOUN
admet-3091	2	2	review	review	VERB
admet-3091	2	3	paper	paper	NOUN
admet-3091	2	4	poly(lactic	poly(lactic	NOUN
admet-3091	2	5	-	-	PUNCT
admet-3091	2	6	co	co	NOUN
admet-3091	2	7	-	-	ADJ
admet-3091	2	8	glycolic	glycolic	ADJ
admet-3091	2	9	acid	acid	NOUN
admet-3091	2	10	)	)	PUNCT
admet-3091	2	11	nanoparticles	nanoparticle	NOUN
admet-3091	2	12	and	and	CCONJ
admet-3091	2	13	microparticles	microparticle	NOUN
admet-3091	2	14	for	for	ADP
admet-3091	2	15	peptide	peptide	ADJ
admet-3091	2	16	delivery	delivery	NOUN
admet-3091	2	17	:	:	PUNCT
admet-3091	3	1	release	release	NOUN
admet-3091	3	2	mechanisms	mechanism	NOUN
admet-3091	3	3	and	and	CCONJ
admet-3091	3	4	controlling	control	VERB
admet-3091	3	5	factors	factor	NOUN
admet-3091	3	6	mohammadmahdi	mohammadmahdi	PROPN
admet-3091	3	7	eshaghi1	eshaghi1	PROPN
admet-3091	3	8	,	,	PUNCT
admet-3091	3	9	marzieh	marzieh	PROPN
admet-3091	3	10	dehghani2	dehghani2	PROPN
admet-3091	3	11	,	,	PUNCT
admet-3091	3	12	azam	azam	PROPN
admet-3091	3	13	abedi3	abedi3	PROPN
admet-3091	3	14	,	,	PUNCT
admet-3091	3	15	mehrdad	mehrdad	NOUN
admet-3091	3	16	moosazadeh	moosazadeh	NOUN
admet-3091	3	17	moghaddam3	moghaddam3	NOUN
admet-3091	3	18	and	and	CCONJ
admet-3091	3	19	ramezan	ramezan	ADJ
admet-3091	3	20	ali	ali	PROPN
admet-3091	3	21	taheri1	taheri1	PROPN
admet-3091	3	22	,	,	PUNCT
admet-3091	3	23	*	*	PUNCT
admet-3091	3	24	1nanobiotechnology	1nanobiotechnology	NUM
admet-3091	3	25	research	research	NOUN
admet-3091	3	26	center	center	NOUN
admet-3091	3	27	,	,	PUNCT
admet-3091	3	28	new	new	ADJ
admet-3091	3	29	health	health	PROPN
admet-3091	3	30	technologies	technologies	PROPN
admet-3091	3	31	institute	institute	PROPN
admet-3091	3	32	,	,	PUNCT
admet-3091	3	33	baqiyatallah	baqiyatallah	PROPN
admet-3091	3	34	university	university	PROPN
admet-3091	3	35	of	of	ADP
admet-3091	3	36	medical	medical	ADJ
admet-3091	3	37	sciences	sciences	PROPN
admet-3091	3	38	,	,	PUNCT
admet-3091	3	39	tehran	tehran	PROPN
admet-3091	3	40	,	,	PUNCT
admet-3091	3	41	iran	iran	PROPN
admet-3091	3	42	2department	2department	NUM
admet-3091	3	43	of	of	ADP
admet-3091	3	44	biophysics	biophysic	NOUN
admet-3091	3	45	,	,	PUNCT
admet-3091	3	46	college	college	NOUN
admet-3091	3	47	of	of	ADP
admet-3091	3	48	biological	biological	ADJ
admet-3091	3	49	sciences	science	NOUN
admet-3091	3	50	,	,	PUNCT
admet-3091	3	51	tarbiat	tarbiat	PROPN
admet-3091	3	52	modares	modares	PROPN
admet-3091	3	53	university	university	PROPN
admet-3091	3	54	,	,	PUNCT
admet-3091	3	55	tehran	tehran	PROPN
admet-3091	3	56	,	,	PUNCT
admet-3091	3	57	iran	iran	PROPN
admet-3091	3	58	3tissue	3tissue	NUM
admet-3091	3	59	engineering	engineering	NOUN
admet-3091	3	60	and	and	CCONJ
admet-3091	3	61	regenerative	regenerative	ADJ
admet-3091	3	62	medicine	medicine	NOUN
admet-3091	3	63	research	research	NOUN
admet-3091	3	64	center	center	NOUN
admet-3091	3	65	,	,	PUNCT
admet-3091	3	66	new	new	ADJ
admet-3091	3	67	health	health	PROPN
admet-3091	3	68	technologies	technologies	PROPN
admet-3091	3	69	institute	institute	PROPN
admet-3091	3	70	,	,	PUNCT
admet-3091	3	71	baqiyatallah	baqiyatallah	PROPN
admet-3091	3	72	university	university	PROPN
admet-3091	3	73	of	of	ADP
admet-3091	3	74	medical	medical	ADJ
admet-3091	3	75	sciences	sciences	PROPN
admet-3091	3	76	,	,	PUNCT
admet-3091	3	77	tehran	tehran	PROPN
admet-3091	3	78	,	,	PUNCT
admet-3091	3	79	iran	iran	PROPN
admet-3091	3	80	*	*	PUNCT
admet-3091	3	81	corresponding	correspond	VERB
admet-3091	3	82	author	author	NOUN
admet-3091	3	83	:	:	PUNCT
admet-3091	3	84	e	e	NOUN
admet-3091	3	85	-	-	NOUN
admet-3091	3	86	mail	mail	NOUN
admet-3091	3	87	:	:	PUNCT
admet-3091	3	88	taheri@bmsu.ac.ir	taheri@bmsu.ac.ir	PRON
admet-3091	3	89	received	receive	VERB
admet-3091	3	90	:	:	PUNCT
admet-3091	3	91	october	october	PROPN
admet-3091	3	92	3	3	NUM
admet-3091	3	93	,	,	PUNCT
admet-3091	3	94	2025	2025	NUM
admet-3091	3	95	;	;	PUNCT
admet-3091	3	96	revised	revise	VERB
admet-3091	3	97	:	:	PUNCT
admet-3091	3	98	december	december	PROPN
admet-3091	3	99	7	7	NUM
admet-3091	3	100	,	,	PUNCT
admet-3091	3	101	2025	2025	NUM
admet-3091	3	102	;	;	PUNCT
admet-3091	3	103	published	publish	VERB
admet-3091	3	104	:	:	PUNCT
admet-3091	3	105	december	december	PROPN
admet-3091	3	106	xx	xx	NUM
admet-3091	3	107	,	,	PUNCT
admet-3091	3	108	2025	2025	NUM
admet-3091	3	109	abstract	abstract	ADJ
admet-3091	3	110	background	background	NOUN
admet-3091	3	111	and	and	CCONJ
admet-3091	3	112	purpose	purpose	NOUN
admet-3091	3	113	:	:	PUNCT
admet-3091	3	114	therapeutic	therapeutic	ADJ
admet-3091	3	115	peptides	peptide	NOUN
admet-3091	3	116	offer	offer	VERB
admet-3091	3	117	high	high	ADJ
admet-3091	3	118	potency	potency	NOUN
admet-3091	3	119	but	but	CCONJ
admet-3091	3	120	are	be	AUX
admet-3091	3	121	limited	limit	VERB
admet-3091	3	122	by	by	ADP
admet-3091	3	123	rapid	rapid	ADJ
admet-3091	3	124	degradation	degradation	NOUN
admet-3091	3	125	,	,	PUNCT
admet-3091	3	126	poor	poor	ADJ
admet-3091	3	127	bioavailability	bioavailability	NOUN
admet-3091	3	128	,	,	PUNCT
admet-3091	3	129	and	and	CCONJ
admet-3091	3	130	the	the	DET
admet-3091	3	131	need	need	NOUN
admet-3091	3	132	for	for	ADP
admet-3091	3	133	frequent	frequent	ADJ
admet-3091	3	134	dosing	dosing	NOUN
admet-3091	3	135	.	.	PUNCT
admet-3091	4	1	poly(lactic	poly(lactic	PROPN
admet-3091	4	2	-	-	PUNCT
admet-3091	4	3	co	co	NOUN
admet-3091	4	4	-	-	ADJ
admet-3091	4	5	glycolic	glycolic	ADJ
admet-3091	4	6	acid	acid	NOUN
admet-3091	4	7	)	)	PUNCT
admet-3091	4	8	(	(	PUNCT
admet-3091	4	9	plga	plga	NOUN
admet-3091	4	10	)	)	PUNCT
admet-3091	4	11	nanoparticles	nanoparticle	NOUN
admet-3091	4	12	and	and	CCONJ
admet-3091	4	13	microparticles	microparticle	NOUN
admet-3091	4	14	are	be	AUX
admet-3091	4	15	effective	effective	ADJ
admet-3091	4	16	carriers	carrier	NOUN
admet-3091	4	17	that	that	PRON
admet-3091	4	18	protect	protect	VERB
admet-3091	4	19	peptides	peptide	NOUN
admet-3091	4	20	and	and	CCONJ
admet-3091	4	21	enable	enable	VERB
admet-3091	4	22	controlled	control	VERB
admet-3091	4	23	release	release	NOUN
admet-3091	4	24	.	.	PUNCT
admet-3091	5	1	this	this	DET
admet-3091	5	2	review	review	NOUN
admet-3091	5	3	summarizes	summarize	VERB
admet-3091	5	4	the	the	DET
admet-3091	5	5	mechanisms	mechanism	NOUN
admet-3091	5	6	governing	govern	VERB
admet-3091	5	7	peptide	peptide	NOUN
admet-3091	5	8	release	release	NOUN
admet-3091	5	9	from	from	ADP
admet-3091	5	10	plga	plga	NOUN
admet-3091	5	11	particles	particle	NOUN
admet-3091	5	12	and	and	CCONJ
admet-3091	5	13	identifies	identify	VERB
admet-3091	5	14	formulation	formulation	NOUN
admet-3091	5	15	factors	factor	NOUN
admet-3091	5	16	critical	critical	ADJ
admet-3091	5	17	for	for	ADP
admet-3091	5	18	optimizing	optimize	VERB
admet-3091	5	19	therapeutic	therapeutic	ADJ
admet-3091	5	20	performance	performance	NOUN
admet-3091	5	21	.	.	PUNCT
admet-3091	6	1	approach	approach	NOUN
admet-3091	6	2	:	:	PUNCT
admet-3091	6	3	a	a	DET
admet-3091	6	4	comprehensive	comprehensive	ADJ
admet-3091	6	5	analysis	analysis	NOUN
admet-3091	6	6	of	of	ADP
admet-3091	6	7	polymer	polymer	NOUN
admet-3091	6	8	characteristics	characteristic	NOUN
admet-3091	6	9	,	,	PUNCT
admet-3091	6	10	particle	particle	NOUN
admet-3091	6	11	design	design	NOUN
admet-3091	6	12	parameters	parameter	NOUN
admet-3091	6	13	,	,	PUNCT
admet-3091	6	14	peptide	peptide	ADJ
admet-3091	6	15	physicochemical	physicochemical	ADJ
admet-3091	6	16	properties	property	NOUN
admet-3091	6	17	,	,	PUNCT
admet-3091	6	18	and	and	CCONJ
admet-3091	6	19	formulation	formulation	NOUN
admet-3091	6	20	strategies	strategy	NOUN
admet-3091	6	21	was	be	AUX
admet-3091	6	22	conducted	conduct	VERB
admet-3091	6	23	using	use	VERB
admet-3091	6	24	data	datum	NOUN
admet-3091	6	25	from	from	ADP
admet-3091	6	26	recent	recent	ADJ
admet-3091	6	27	studies	study	NOUN
admet-3091	6	28	.	.	PUNCT
admet-3091	7	1	release	release	NOUN
admet-3091	7	2	mechanisms	mechanism	NOUN
admet-3091	7	3	,	,	PUNCT
admet-3091	7	4	including	include	VERB
admet-3091	7	5	diffusion	diffusion	NOUN
admet-3091	7	6	,	,	PUNCT
admet-3091	7	7	polymer	polymer	NOUN
admet-3091	7	8	degradation	degradation	NOUN
admet-3091	7	9	,	,	PUNCT
admet-3091	7	10	and	and	CCONJ
admet-3091	7	11	erosion	erosion	NOUN
admet-3091	7	12	,	,	PUNCT
admet-3091	7	13	were	be	AUX
admet-3091	7	14	examined	examine	VERB
admet-3091	7	15	alongside	alongside	ADP
admet-3091	7	16	manufacturing	manufacturing	NOUN
admet-3091	7	17	methods	method	NOUN
admet-3091	7	18	.	.	PUNCT
admet-3091	8	1	the	the	DET
admet-3091	8	2	review	review	NOUN
admet-3091	8	3	also	also	ADV
admet-3091	8	4	evaluates	evaluate	VERB
admet-3091	8	5	clinical	clinical	ADJ
admet-3091	8	6	plga	plga	NOUN
admet-3091	8	7	-	-	PUNCT
admet-3091	8	8	based	base	VERB
admet-3091	8	9	peptide	peptide	NOUN
admet-3091	8	10	products	product	NOUN
admet-3091	8	11	to	to	PART
admet-3091	8	12	highlight	highlight	VERB
admet-3091	8	13	translational	translational	ADJ
admet-3091	8	14	relevance	relevance	NOUN
admet-3091	8	15	.	.	PUNCT
admet-3091	9	1	key	key	ADJ
admet-3091	9	2	results	result	NOUN
admet-3091	9	3	:	:	PUNCT
admet-3091	9	4	peptide	peptide	ADJ
admet-3091	9	5	release	release	NOUN
admet-3091	9	6	profiles	profile	NOUN
admet-3091	9	7	are	be	AUX
admet-3091	9	8	strongly	strongly	ADV
admet-3091	9	9	influenced	influence	VERB
admet-3091	9	10	by	by	ADP
admet-3091	9	11	plga	plga	NOUN
admet-3091	9	12	molecular	molecular	ADJ
admet-3091	9	13	weight	weight	NOUN
admet-3091	9	14	,	,	PUNCT
admet-3091	9	15	lactide	lactide	ADV
admet-3091	9	16	:	:	PUNCT
admet-3091	9	17	glycolide	glycolide	ADJ
admet-3091	9	18	ratio	ratio	NOUN
admet-3091	9	19	,	,	PUNCT
admet-3091	9	20	particle	particle	NOUN
admet-3091	9	21	size	size	NOUN
admet-3091	9	22	,	,	PUNCT
admet-3091	9	23	end	end	NOUN
admet-3091	9	24	-	-	PUNCT
admet-3091	9	25	group	group	NOUN
admet-3091	9	26	chemistry	chemistry	NOUN
admet-3091	9	27	,	,	PUNCT
admet-3091	9	28	drug	drug	NOUN
admet-3091	9	29	loading	loading	NOUN
admet-3091	9	30	,	,	PUNCT
admet-3091	9	31	and	and	CCONJ
admet-3091	9	32	excipients	excipient	NOUN
admet-3091	9	33	.	.	PUNCT
admet-3091	10	1	lower	low	ADJ
admet-3091	10	2	polymer	polymer	NOUN
admet-3091	10	3	molecular	molecular	ADJ
admet-3091	10	4	weight	weight	NOUN
admet-3091	10	5	,	,	PUNCT
admet-3091	10	6	higher	high	ADJ
admet-3091	10	7	glycolide	glycolide	NOUN
admet-3091	10	8	content	content	NOUN
admet-3091	10	9	,	,	PUNCT
admet-3091	10	10	and	and	CCONJ
admet-3091	10	11	smaller	small	ADJ
admet-3091	10	12	particle	particle	NOUN
admet-3091	10	13	dimensions	dimension	NOUN
admet-3091	10	14	accelerate	accelerate	NOUN
admet-3091	10	15	release	release	NOUN
admet-3091	10	16	,	,	PUNCT
admet-3091	10	17	whereas	whereas	SCONJ
admet-3091	10	18	cationic	cationic	ADJ
admet-3091	10	19	peptides	peptide	NOUN
admet-3091	10	20	experience	experience	VERB
admet-3091	10	21	electrostatic	electrostatic	ADJ
admet-3091	10	22	retention	retention	NOUN
admet-3091	10	23	within	within	ADP
admet-3091	10	24	degrading	degrade	VERB
admet-3091	10	25	matrices	matrix	NOUN
admet-3091	10	26	.	.	PUNCT
admet-3091	11	1	additives	additive	NOUN
admet-3091	11	2	such	such	ADJ
admet-3091	11	3	as	as	ADP
admet-3091	11	4	peg	peg	NOUN
admet-3091	11	5	,	,	PUNCT
admet-3091	11	6	magnesium	magnesium	NOUN
admet-3091	11	7	salts	salt	NOUN
admet-3091	11	8	,	,	PUNCT
admet-3091	11	9	and	and	CCONJ
admet-3091	11	10	chitosan	chitosan	ADJ
admet-3091	11	11	coatings	coating	NOUN
admet-3091	11	12	effectively	effectively	ADV
admet-3091	11	13	modulate	modulate	VERB
admet-3091	11	14	burst	burst	ADJ
admet-3091	11	15	release	release	NOUN
admet-3091	11	16	and	and	CCONJ
admet-3091	11	17	stability	stability	NOUN
admet-3091	11	18	.	.	PUNCT
admet-3091	12	1	plga	plga	NOUN
admet-3091	12	2	systems	system	NOUN
admet-3091	12	3	typically	typically	ADV
admet-3091	12	4	display	display	VERB
admet-3091	12	5	triphasic	triphasic	ADJ
admet-3091	12	6	release	release	NOUN
admet-3091	12	7	profiles	profile	NOUN
admet-3091	12	8	governed	govern	VERB
admet-3091	12	9	by	by	ADP
admet-3091	12	10	diffusion	diffusion	NOUN
admet-3091	12	11	and	and	CCONJ
admet-3091	12	12	erosion	erosion	NOUN
admet-3091	12	13	.	.	PUNCT
admet-3091	13	1	several	several	ADJ
admet-3091	13	2	plga	plga	NOUN
admet-3091	13	3	microparticle	microparticle	NOUN
admet-3091	13	4	-	-	PUNCT
admet-3091	13	5	based	base	VERB
admet-3091	13	6	peptide	peptide	NOUN
admet-3091	13	7	depots	depot	NOUN
admet-3091	13	8	have	have	AUX
admet-3091	13	9	achieved	achieve	VERB
admet-3091	13	10	clinical	clinical	ADJ
admet-3091	13	11	success	success	NOUN
admet-3091	13	12	,	,	PUNCT
admet-3091	13	13	although	although	SCONJ
admet-3091	13	14	no	no	DET
admet-3091	13	15	nanoparticle	nanoparticle	NOUN
admet-3091	13	16	-	-	PUNCT
admet-3091	13	17	based	base	VERB
admet-3091	13	18	products	product	NOUN
admet-3091	13	19	have	have	AUX
admet-3091	13	20	yet	yet	ADV
admet-3091	13	21	reached	reach	VERB
admet-3091	13	22	the	the	DET
admet-3091	13	23	market	market	NOUN
admet-3091	13	24	due	due	ADP
admet-3091	13	25	to	to	ADP
admet-3091	13	26	manufacturing	manufacturing	NOUN
admet-3091	13	27	and	and	CCONJ
admet-3091	13	28	regulatory	regulatory	ADJ
admet-3091	13	29	challenges	challenge	NOUN
admet-3091	13	30	.	.	PUNCT
admet-3091	14	1	conclusion	conclusion	NOUN
admet-3091	14	2	:	:	PUNCT
admet-3091	14	3	plga	plga	NOUN
admet-3091	14	4	nanoand	nanoand	NOUN
admet-3091	14	5	microparticles	microparticle	NOUN
admet-3091	14	6	provide	provide	VERB
admet-3091	14	7	versatile	versatile	ADJ
admet-3091	14	8	,	,	PUNCT
admet-3091	14	9	tunable	tunable	ADJ
admet-3091	14	10	platforms	platform	NOUN
admet-3091	14	11	for	for	ADP
admet-3091	14	12	sustained	sustained	ADJ
admet-3091	14	13	peptide	peptide	NOUN
admet-3091	14	14	delivery	delivery	NOUN
admet-3091	14	15	.	.	PUNCT
admet-3091	15	1	understanding	understand	VERB
admet-3091	15	2	the	the	DET
admet-3091	15	3	interplay	interplay	NOUN
admet-3091	15	4	between	between	ADP
admet-3091	15	5	polymer	polymer	NOUN
admet-3091	15	6	properties	property	NOUN
admet-3091	15	7	,	,	PUNCT
admet-3091	15	8	particle	particle	NOUN
admet-3091	15	9	architecture	architecture	NOUN
admet-3091	15	10	,	,	PUNCT
admet-3091	15	11	and	and	CCONJ
admet-3091	15	12	peptide	peptide	ADJ
admet-3091	15	13	characteristics	characteristic	NOUN
admet-3091	15	14	is	be	AUX
admet-3091	15	15	essential	essential	ADJ
admet-3091	15	16	for	for	ADP
admet-3091	15	17	designing	design	VERB
admet-3091	15	18	nextgeneration	nextgeneration	NOUN
admet-3091	15	19	long	long	ADV
admet-3091	15	20	-	-	PUNCT
admet-3091	15	21	acting	act	VERB
admet-3091	15	22	formulations	formulation	NOUN
admet-3091	15	23	with	with	ADP
admet-3091	15	24	improved	improved	ADJ
admet-3091	15	25	efficacy	efficacy	NOUN
admet-3091	15	26	and	and	CCONJ
admet-3091	15	27	clinical	clinical	ADJ
admet-3091	15	28	translation	translation	NOUN
admet-3091	15	29	.	.	PUNCT
admet-3091	16	1	©	©	PROPN
admet-3091	16	2	2025	2025	NUM
admet-3091	16	3	by	by	ADP
admet-3091	16	4	the	the	DET
admet-3091	16	5	authors	author	NOUN
admet-3091	16	6	.	.	PUNCT
admet-3091	17	1	this	this	DET
admet-3091	17	2	article	article	NOUN
admet-3091	17	3	is	be	AUX
admet-3091	17	4	an	an	DET
admet-3091	17	5	open	open	ADJ
admet-3091	17	6	-	-	PUNCT
admet-3091	17	7	access	access	NOUN
admet-3091	17	8	article	article	NOUN
admet-3091	17	9	distributed	distribute	VERB
admet-3091	17	10	under	under	ADP
admet-3091	17	11	the	the	DET
admet-3091	17	12	terms	term	NOUN
admet-3091	17	13	and	and	CCONJ
admet-3091	17	14	conditions	condition	NOUN
admet-3091	17	15	of	of	ADP
admet-3091	17	16	the	the	DET
admet-3091	17	17	creative	creative	ADJ
admet-3091	17	18	commons	common	NOUN
admet-3091	17	19	attribution	attribution	NOUN
admet-3091	17	20	license	license	NOUN
admet-3091	17	21	(	(	PUNCT
admet-3091	17	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-3091	17	23	)	)	PUNCT
admet-3091	17	24	.	.	PUNCT
admet-3091	18	1	keywords	keyword	VERB
admet-3091	18	2	poly(lactic	poly(lactic	NOUN
admet-3091	18	3	-	-	PUNCT
admet-3091	18	4	co	co	NOUN
admet-3091	18	5	-	-	ADJ
admet-3091	18	6	glycolic	glycolic	ADJ
admet-3091	18	7	acid	acid	NOUN
admet-3091	18	8	)	)	PUNCT
admet-3091	18	9	;	;	PUNCT
admet-3091	18	10	drug	drug	NOUN
admet-3091	18	11	delivery	delivery	NOUN
admet-3091	18	12	;	;	PUNCT
admet-3091	18	13	particle	particle	NOUN
admet-3091	18	14	;	;	PUNCT
admet-3091	18	15	nanomaterial	nanomaterial	ADJ
admet-3091	18	16	introduction	introduction	NOUN
admet-3091	18	17	recent	recent	ADJ
admet-3091	18	18	studies	study	NOUN
admet-3091	18	19	have	have	AUX
admet-3091	18	20	shown	show	VERB
admet-3091	18	21	that	that	SCONJ
admet-3091	18	22	conventional	conventional	ADJ
admet-3091	18	23	drug	drug	NOUN
admet-3091	18	24	delivery	delivery	NOUN
admet-3091	18	25	methods	method	NOUN
admet-3091	18	26	face	face	VERB
admet-3091	18	27	significant	significant	ADJ
admet-3091	18	28	limitations	limitation	NOUN
admet-3091	18	29	in	in	ADP
admet-3091	18	30	precisely	precisely	ADV
admet-3091	18	31	controlling	control	VERB
admet-3091	18	32	the	the	DET
admet-3091	18	33	timing	timing	NOUN
admet-3091	18	34	and	and	CCONJ
admet-3091	18	35	location	location	NOUN
admet-3091	18	36	of	of	ADP
admet-3091	18	37	drug	drug	NOUN
admet-3091	18	38	release	release	NOUN
admet-3091	18	39	.	.	PUNCT
admet-3091	19	1	after	after	ADP
admet-3091	19	2	administration	administration	NOUN
admet-3091	19	3	,	,	PUNCT
admet-3091	19	4	the	the	DET
admet-3091	19	5	active	active	ADJ
admet-3091	19	6	compound	compound	NOUN
admet-3091	19	7	often	often	ADV
admet-3091	19	8	distributes	distribute	VERB
admet-3091	19	9	throughout	throughout	ADP
admet-3091	19	10	the	the	DET
admet-3091	19	11	body	body	NOUN
admet-3091	19	12	via	via	ADP
admet-3091	19	13	the	the	DET
admet-3091	19	14	bloodstream	bloodstream	NOUN
admet-3091	19	15	,	,	PUNCT
admet-3091	19	16	leading	lead	VERB
admet-3091	19	17	to	to	ADP
admet-3091	19	18	significant	significant	ADJ
admet-3091	19	19	fluctuations	fluctuation	NOUN
admet-3091	19	20	in	in	ADP
admet-3091	19	21	drug	drug	NOUN
admet-3091	19	22	concentration	concentration	NOUN
admet-3091	19	23	.	.	PUNCT
admet-3091	20	1	in	in	ADP
admet-3091	20	2	many	many	ADJ
admet-3091	20	3	cases	case	NOUN
admet-3091	20	4	,	,	PUNCT
admet-3091	20	5	plasma	plasma	NOUN
admet-3091	20	6	levels	level	NOUN
admet-3091	20	7	peak	peak	VERB
admet-3091	20	8	shortly	shortly	ADV
admet-3091	20	9	after	after	ADP
admet-3091	20	10	administration	administration	NOUN
admet-3091	20	11	but	but	CCONJ
admet-3091	20	12	rapidly	rapidly	ADV
admet-3091	20	13	decline	decline	VERB
admet-3091	20	14	below	below	ADP
admet-3091	20	15	the	the	DET
admet-3091	20	16	http://doi.org/10.5599/admet.3091	http://doi.org/10.5599/admet.3091	NUM
admet-3091	20	17	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	20	18	https://pub.iapchem.org/ojs/index.php/admet	https://pub.iapchem.org/ojs/index.php/admet	NOUN
admet-3091	20	19	mailto:taheri@bmsu.ac.ir	mailto:taheri@bmsu.ac.ir	VERB
admet-3091	20	20	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-3091	20	21	https://orcid.org/0000-0003-1612-6989	https://orcid.org/0000-0003-1612-6989	PROPN
admet-3091	20	22	https://orcid.org/0009-0001-5121-7037	https://orcid.org/0009-0001-5121-7037	VERB
admet-3091	20	23	https://orcid.org/0000-0003-2750-1203	https://orcid.org/0000-0003-2750-1203	PROPN
admet-3091	20	24	https://orcid.org/0000-0002-4645-8661	https://orcid.org/0000-0002-4645-8661	PROPN
admet-3091	21	1	https://orcid.org/0000-0003-1394-6412	https://orcid.org/0000-0003-1394-6412	PROPN
admet-3091	21	2	m.	m.	PROPN
admet-3091	21	3	eshaghi	eshaghi	PROPN
admet-3091	21	4	et	et	PROPN
admet-3091	21	5	al	al	PROPN
admet-3091	21	6	.	.	PROPN
admet-3091	21	7	admet	admet	PROPN
admet-3091	21	8	&	&	CCONJ
admet-3091	21	9	dmpk	dmpk	PROPN
admet-3091	21	10	00(0	00(0	PROPN
admet-3091	21	11	)	)	PUNCT
admet-3091	21	12	(	(	PUNCT
admet-3091	21	13	2025	2025	NUM
admet-3091	21	14	)	)	PUNCT
admet-3091	21	15	3091	3091	NUM
admet-3091	21	16	2	2	NUM
admet-3091	21	17	therapeutic	therapeutic	ADJ
admet-3091	21	18	threshold	threshold	NOUN
admet-3091	21	19	.	.	PUNCT
admet-3091	22	1	this	this	PRON
admet-3091	22	2	necessitates	necessitate	VERB
admet-3091	22	3	frequent	frequent	ADJ
admet-3091	22	4	and	and	CCONJ
admet-3091	22	5	prolonged	prolong	VERB
admet-3091	22	6	dosing	dose	VERB
admet-3091	22	7	to	to	PART
admet-3091	22	8	maintain	maintain	VERB
admet-3091	22	9	effective	effective	ADJ
admet-3091	22	10	treatment	treatment	NOUN
admet-3091	22	11	.	.	PUNCT
admet-3091	23	1	to	to	PART
admet-3091	23	2	address	address	VERB
admet-3091	23	3	these	these	DET
admet-3091	23	4	challenges	challenge	NOUN
admet-3091	23	5	,	,	PUNCT
admet-3091	23	6	advanced	advanced	ADJ
admet-3091	23	7	drug	drug	NOUN
admet-3091	23	8	delivery	delivery	NOUN
admet-3091	23	9	systems	system	NOUN
admet-3091	23	10	(	(	PUNCT
admet-3091	23	11	dds	dds	PROPN
admet-3091	23	12	)	)	PUNCT
admet-3091	23	13	have	have	AUX
admet-3091	23	14	been	be	AUX
admet-3091	23	15	developed	develop	VERB
admet-3091	23	16	.	.	PUNCT
admet-3091	24	1	these	these	DET
admet-3091	24	2	systems	system	NOUN
admet-3091	24	3	are	be	AUX
admet-3091	24	4	designed	design	VERB
admet-3091	24	5	to	to	PART
admet-3091	24	6	release	release	VERB
admet-3091	24	7	drugs	drug	NOUN
admet-3091	24	8	slowly	slowly	ADV
admet-3091	24	9	and	and	CCONJ
admet-3091	24	10	continuously	continuously	ADV
admet-3091	24	11	or	or	CCONJ
admet-3091	24	12	maintain	maintain	VERB
admet-3091	24	13	a	a	DET
admet-3091	24	14	steady	steady	ADJ
admet-3091	24	15	release	release	NOUN
admet-3091	24	16	rate	rate	NOUN
admet-3091	24	17	,	,	PUNCT
admet-3091	24	18	ultimately	ultimately	ADV
admet-3091	24	19	enabling	enable	VERB
admet-3091	24	20	targeted	target	VERB
admet-3091	24	21	delivery	delivery	NOUN
admet-3091	24	22	to	to	ADP
admet-3091	24	23	specific	specific	ADJ
admet-3091	24	24	tissues	tissue	NOUN
admet-3091	24	25	or	or	CCONJ
admet-3091	24	26	organs	organ	NOUN
admet-3091	24	27	[	[	X
admet-3091	24	28	1,2	1,2	NUM
admet-3091	24	29	]	]	PUNCT
admet-3091	24	30	.	.	PUNCT
admet-3091	25	1	today	today	NOUN
admet-3091	25	2	,	,	PUNCT
admet-3091	25	3	polymeric	polymeric	ADJ
admet-3091	25	4	ddss	ddss	NOUN
admet-3091	25	5	are	be	AUX
admet-3091	25	6	emerging	emerge	VERB
admet-3091	25	7	as	as	ADP
admet-3091	25	8	a	a	DET
admet-3091	25	9	promising	promising	ADJ
admet-3091	25	10	solution	solution	NOUN
admet-3091	25	11	to	to	PART
admet-3091	25	12	overcome	overcome	VERB
admet-3091	25	13	the	the	DET
admet-3091	25	14	challenges	challenge	NOUN
admet-3091	25	15	in	in	ADP
admet-3091	25	16	drug	drug	NOUN
admet-3091	25	17	delivery	delivery	NOUN
admet-3091	25	18	.	.	PUNCT
admet-3091	26	1	polymeric	polymeric	ADJ
admet-3091	26	2	ddss	ddss	NOUN
admet-3091	26	3	have	have	AUX
admet-3091	26	4	emerged	emerge	VERB
admet-3091	26	5	as	as	ADP
admet-3091	26	6	a	a	DET
admet-3091	26	7	versatile	versatile	ADJ
admet-3091	26	8	and	and	CCONJ
admet-3091	26	9	widely	widely	ADV
admet-3091	26	10	explored	explore	VERB
admet-3091	26	11	platform	platform	NOUN
admet-3091	26	12	for	for	ADP
admet-3091	26	13	drug	drug	NOUN
admet-3091	26	14	delivery	delivery	NOUN
admet-3091	26	15	due	due	ADP
admet-3091	26	16	to	to	ADP
admet-3091	26	17	their	their	PRON
admet-3091	26	18	tuneable	tuneable	ADJ
admet-3091	26	19	physicochemical	physicochemical	ADJ
admet-3091	26	20	properties	property	NOUN
admet-3091	26	21	,	,	PUNCT
admet-3091	26	22	biocompatibility	biocompatibility	NOUN
admet-3091	26	23	,	,	PUNCT
admet-3091	26	24	and	and	CCONJ
admet-3091	26	25	ability	ability	NOUN
admet-3091	26	26	to	to	PART
admet-3091	26	27	protect	protect	VERB
admet-3091	26	28	therapeutic	therapeutic	ADJ
admet-3091	26	29	agents	agent	NOUN
admet-3091	26	30	from	from	ADP
admet-3091	26	31	degradation	degradation	NOUN
admet-3091	26	32	.	.	PUNCT
admet-3091	27	1	these	these	DET
admet-3091	27	2	carriers	carrier	NOUN
admet-3091	27	3	are	be	AUX
admet-3091	27	4	typically	typically	ADV
admet-3091	27	5	composed	compose	VERB
admet-3091	27	6	of	of	ADP
admet-3091	27	7	biodegradable	biodegradable	ADJ
admet-3091	27	8	synthetic	synthetic	ADJ
admet-3091	27	9	or	or	CCONJ
admet-3091	27	10	natural	natural	ADJ
admet-3091	27	11	polymers	polymer	NOUN
admet-3091	27	12	,	,	PUNCT
admet-3091	27	13	such	such	ADJ
admet-3091	27	14	as	as	ADP
admet-3091	27	15	poly(lacticco	poly(lacticco	NOUN
admet-3091	27	16	-	-	PUNCT
admet-3091	27	17	glycolic	glycolic	NOUN
admet-3091	27	18	acid	acid	NOUN
admet-3091	27	19	)	)	PUNCT
admet-3091	27	20	(	(	PUNCT
admet-3091	27	21	plga	plga	NOUN
admet-3091	27	22	)	)	PUNCT
admet-3091	27	23	,	,	PUNCT
admet-3091	27	24	polyethylene	polyethylene	NOUN
admet-3091	27	25	glycol	glycol	NOUN
admet-3091	27	26	(	(	PUNCT
admet-3091	27	27	peg	peg	NOUN
admet-3091	27	28	)	)	PUNCT
admet-3091	27	29	,	,	PUNCT
admet-3091	27	30	chitosan	chitosan	NOUN
admet-3091	27	31	,	,	PUNCT
admet-3091	27	32	alginate	alginate	NOUN
admet-3091	27	33	,	,	PUNCT
admet-3091	27	34	or	or	CCONJ
admet-3091	27	35	polycaprolactone	polycaprolactone	NOUN
admet-3091	27	36	(	(	PUNCT
admet-3091	27	37	pcl	pcl	PROPN
admet-3091	27	38	)	)	PUNCT
admet-3091	27	39	.	.	PUNCT
admet-3091	28	1	common	common	ADJ
admet-3091	28	2	types	type	NOUN
admet-3091	28	3	include	include	VERB
admet-3091	28	4	polymeric	polymeric	ADJ
admet-3091	28	5	nanoparticles	nanoparticle	NOUN
admet-3091	28	6	and	and	CCONJ
admet-3091	28	7	microparticles	microparticle	NOUN
admet-3091	28	8	,	,	PUNCT
admet-3091	28	9	micelles	micelle	NOUN
admet-3091	28	10	,	,	PUNCT
admet-3091	28	11	dendrimers	dendrimer	NOUN
admet-3091	28	12	,	,	PUNCT
admet-3091	28	13	nanogels	nanogel	NOUN
admet-3091	28	14	,	,	PUNCT
admet-3091	28	15	and	and	CCONJ
admet-3091	28	16	polymersomes	polymersome	NOUN
admet-3091	28	17	,	,	PUNCT
admet-3091	28	18	each	each	PRON
admet-3091	28	19	offering	offer	VERB
admet-3091	28	20	unique	unique	ADJ
admet-3091	28	21	structural	structural	ADJ
admet-3091	28	22	and	and	CCONJ
admet-3091	28	23	functional	functional	ADJ
admet-3091	28	24	advantages	advantage	NOUN
admet-3091	28	25	.	.	PUNCT
admet-3091	29	1	for	for	ADP
admet-3091	29	2	example	example	NOUN
admet-3091	29	3	,	,	PUNCT
admet-3091	29	4	micelles	micelle	NOUN
admet-3091	29	5	enhance	enhance	VERB
admet-3091	29	6	the	the	DET
admet-3091	29	7	solubility	solubility	NOUN
admet-3091	29	8	of	of	ADP
admet-3091	29	9	hydrophobic	hydrophobic	NOUN
admet-3091	29	10	drugs	drug	NOUN
admet-3091	29	11	,	,	PUNCT
admet-3091	29	12	dendrimers	dendrimer	NOUN
admet-3091	29	13	provide	provide	VERB
admet-3091	29	14	multivalent	multivalent	NOUN
admet-3091	29	15	attachment	attachment	NOUN
admet-3091	29	16	sites	site	NOUN
admet-3091	29	17	,	,	PUNCT
admet-3091	29	18	and	and	CCONJ
admet-3091	29	19	nanogels	nanogel	NOUN
admet-3091	29	20	facilitate	facilitate	VERB
admet-3091	29	21	stimulus	stimulus	X
admet-3091	29	22	-	-	PUNCT
admet-3091	29	23	responsive	responsive	ADJ
admet-3091	29	24	drug	drug	NOUN
admet-3091	29	25	release	release	NOUN
admet-3091	29	26	.	.	PUNCT
admet-3091	30	1	additionally	additionally	ADV
admet-3091	30	2	,	,	PUNCT
admet-3091	30	3	these	these	DET
admet-3091	30	4	systems	system	NOUN
admet-3091	30	5	can	can	AUX
admet-3091	30	6	be	be	AUX
admet-3091	30	7	functionalized	functionalize	VERB
admet-3091	30	8	for	for	ADP
admet-3091	30	9	targeted	target	VERB
admet-3091	30	10	delivery	delivery	NOUN
admet-3091	30	11	by	by	ADP
admet-3091	30	12	conjugating	conjugate	VERB
admet-3091	30	13	ligands	ligand	NOUN
admet-3091	30	14	,	,	PUNCT
admet-3091	30	15	antibodies	antibodie	VERB
admet-3091	30	16	,	,	PUNCT
admet-3091	30	17	or	or	CCONJ
admet-3091	30	18	aptamers	aptamer	NOUN
admet-3091	30	19	to	to	ADP
admet-3091	30	20	their	their	PRON
admet-3091	30	21	surface	surface	NOUN
admet-3091	30	22	.	.	PUNCT
admet-3091	31	1	the	the	DET
admet-3091	31	2	advantages	advantage	NOUN
admet-3091	31	3	of	of	ADP
admet-3091	31	4	using	use	VERB
admet-3091	31	5	polymeric	polymeric	ADJ
admet-3091	31	6	dds	dd	NOUN
admet-3091	31	7	are	be	AUX
admet-3091	31	8	substantial	substantial	ADJ
admet-3091	31	9	.	.	PUNCT
admet-3091	32	1	they	they	PRON
admet-3091	32	2	can	can	AUX
admet-3091	32	3	improve	improve	VERB
admet-3091	32	4	the	the	DET
admet-3091	32	5	pharmacokinetics	pharmacokinetic	NOUN
admet-3091	32	6	and	and	CCONJ
admet-3091	32	7	bioavailability	bioavailability	NOUN
admet-3091	32	8	of	of	ADP
admet-3091	32	9	poorly	poorly	ADV
admet-3091	32	10	soluble	soluble	ADJ
admet-3091	32	11	drugs	drug	NOUN
admet-3091	32	12	,	,	PUNCT
admet-3091	32	13	prolong	prolong	VERB
admet-3091	32	14	systemic	systemic	ADJ
admet-3091	32	15	circulation	circulation	NOUN
admet-3091	32	16	,	,	PUNCT
admet-3091	32	17	and	and	CCONJ
admet-3091	32	18	enable	enable	VERB
admet-3091	32	19	controlled	control	VERB
admet-3091	32	20	or	or	CCONJ
admet-3091	32	21	sustained	sustained	ADJ
admet-3091	32	22	release	release	NOUN
admet-3091	32	23	profiles	profile	NOUN
admet-3091	32	24	[	[	X
admet-3091	32	25	3	3	NUM
admet-3091	32	26	]	]	PUNCT
admet-3091	32	27	.	.	PUNCT
admet-3091	33	1	these	these	DET
admet-3091	33	2	properties	property	NOUN
admet-3091	33	3	reduce	reduce	VERB
admet-3091	33	4	dosing	dose	VERB
admet-3091	33	5	frequency	frequency	NOUN
admet-3091	33	6	and	and	CCONJ
admet-3091	33	7	systemic	systemic	ADJ
admet-3091	33	8	side	side	NOUN
admet-3091	33	9	effects	effect	NOUN
admet-3091	33	10	by	by	ADP
admet-3091	33	11	concentrating	concentrate	VERB
admet-3091	33	12	the	the	DET
admet-3091	33	13	therapeutic	therapeutic	ADJ
admet-3091	33	14	effect	effect	NOUN
admet-3091	33	15	at	at	ADP
admet-3091	33	16	the	the	DET
admet-3091	33	17	disease	disease	NOUN
admet-3091	33	18	site	site	NOUN
admet-3091	33	19	.	.	PUNCT
admet-3091	34	1	furthermore	furthermore	ADV
admet-3091	34	2	,	,	PUNCT
admet-3091	34	3	the	the	DET
admet-3091	34	4	biodegradability	biodegradability	NOUN
admet-3091	34	5	of	of	ADP
admet-3091	34	6	polymers	polymer	NOUN
admet-3091	34	7	such	such	ADJ
admet-3091	34	8	as	as	ADP
admet-3091	34	9	plga	plga	NOUN
admet-3091	34	10	,	,	PUNCT
admet-3091	34	11	pcl	pcl	PROPN
admet-3091	34	12	,	,	PUNCT
admet-3091	34	13	etc	etc	X
admet-3091	34	14	.	.	X
admet-3091	34	15	ensures	ensure	VERB
admet-3091	34	16	safe	safe	ADJ
admet-3091	34	17	clearance	clearance	NOUN
admet-3091	34	18	from	from	ADP
admet-3091	34	19	the	the	DET
admet-3091	34	20	body	body	NOUN
admet-3091	34	21	,	,	PUNCT
admet-3091	34	22	and	and	CCONJ
admet-3091	34	23	their	their	PRON
admet-3091	34	24	design	design	NOUN
admet-3091	34	25	flexibility	flexibility	NOUN
admet-3091	34	26	allows	allow	VERB
admet-3091	34	27	the	the	DET
admet-3091	34	28	incorporation	incorporation	NOUN
admet-3091	34	29	of	of	ADP
admet-3091	34	30	diverse	diverse	ADJ
admet-3091	34	31	therapeutic	therapeutic	ADJ
admet-3091	34	32	agents	agent	NOUN
admet-3091	34	33	,	,	PUNCT
admet-3091	34	34	including	include	VERB
admet-3091	34	35	small	small	ADJ
admet-3091	34	36	molecules	molecule	NOUN
admet-3091	34	37	,	,	PUNCT
admet-3091	34	38	peptides	peptide	NOUN
admet-3091	34	39	,	,	PUNCT
admet-3091	34	40	and	and	CCONJ
admet-3091	34	41	nucleic	nucleic	ADJ
admet-3091	34	42	acids	acid	NOUN
admet-3091	34	43	.	.	PUNCT
admet-3091	35	1	co	co	NOUN
admet-3091	35	2	-	-	NOUN
admet-3091	35	3	delivery	delivery	NOUN
admet-3091	35	4	capabilities	capability	NOUN
admet-3091	35	5	of	of	ADP
admet-3091	35	6	polymeric	polymeric	ADJ
admet-3091	35	7	systems	system	NOUN
admet-3091	35	8	also	also	ADV
admet-3091	35	9	offer	offer	VERB
admet-3091	35	10	significant	significant	ADJ
admet-3091	35	11	potential	potential	NOUN
admet-3091	35	12	for	for	ADP
admet-3091	35	13	synergistic	synergistic	ADJ
admet-3091	35	14	combination	combination	NOUN
admet-3091	35	15	therapies	therapy	NOUN
admet-3091	35	16	.	.	PUNCT
admet-3091	36	1	indeed	indeed	ADV
admet-3091	36	2	,	,	PUNCT
admet-3091	36	3	plga	plga	VERB
admet-3091	36	4	is	be	AUX
admet-3091	36	5	one	one	NUM
admet-3091	36	6	of	of	ADP
admet-3091	36	7	the	the	DET
admet-3091	36	8	most	most	ADV
admet-3091	36	9	widely	widely	ADV
admet-3091	36	10	utilized	utilize	VERB
admet-3091	36	11	biodegradable	biodegradable	ADJ
admet-3091	36	12	polymers	polymer	NOUN
admet-3091	36	13	for	for	ADP
admet-3091	36	14	controlled	control	VERB
admet-3091	36	15	peptide	peptide	NOUN
admet-3091	36	16	delivery	delivery	NOUN
admet-3091	36	17	systems	system	NOUN
admet-3091	36	18	due	due	ADP
admet-3091	36	19	to	to	ADP
admet-3091	36	20	its	its	PRON
admet-3091	36	21	biocompatibility	biocompatibility	NOUN
admet-3091	36	22	,	,	PUNCT
admet-3091	36	23	tuneable	tuneable	ADJ
admet-3091	36	24	degradation	degradation	NOUN
admet-3091	36	25	kinetics	kinetic	NOUN
admet-3091	36	26	,	,	PUNCT
admet-3091	36	27	and	and	CCONJ
admet-3091	36	28	well	well	ADV
admet-3091	36	29	-	-	PUNCT
admet-3091	36	30	established	establish	VERB
admet-3091	36	31	regulatory	regulatory	ADJ
admet-3091	36	32	approval	approval	NOUN
admet-3091	36	33	.	.	PUNCT
admet-3091	37	1	first	first	ADV
admet-3091	37	2	synthesized	synthesize	VERB
admet-3091	37	3	in	in	ADP
admet-3091	37	4	the	the	DET
admet-3091	37	5	1970s	1970	NOUN
admet-3091	37	6	,	,	PUNCT
admet-3091	37	7	plga	plga	NOUN
admet-3091	37	8	undergoes	undergo	VERB
admet-3091	37	9	hydrolytic	hydrolytic	ADJ
admet-3091	37	10	degradation	degradation	NOUN
admet-3091	37	11	to	to	ADP
admet-3091	37	12	lactic	lactic	ADJ
admet-3091	37	13	and	and	CCONJ
admet-3091	37	14	glycolic	glycolic	NOUN
admet-3091	37	15	acid	acid	NOUN
admet-3091	37	16	metabolites	metabolite	NOUN
admet-3091	37	17	,	,	PUNCT
admet-3091	37	18	which	which	PRON
admet-3091	37	19	are	be	AUX
admet-3091	37	20	naturally	naturally	ADV
admet-3091	37	21	cleared	clear	VERB
admet-3091	37	22	via	via	ADP
admet-3091	37	23	the	the	DET
admet-3091	37	24	krebs	krebs	NOUN
admet-3091	37	25	cycle	cycle	NOUN
admet-3091	37	26	,	,	PUNCT
admet-3091	37	27	thereby	thereby	ADV
admet-3091	37	28	eliminating	eliminate	VERB
admet-3091	37	29	longterm	longterm	ADJ
admet-3091	37	30	toxicity	toxicity	NOUN
admet-3091	37	31	concerns	concern	NOUN
admet-3091	37	32	,	,	PUNCT
admet-3091	37	33	making	make	VERB
admet-3091	37	34	it	it	PRON
admet-3091	37	35	ideal	ideal	ADJ
admet-3091	37	36	for	for	ADP
admet-3091	37	37	sustained	sustain	VERB
admet-3091	37	38	-	-	PUNCT
admet-3091	37	39	release	release	NOUN
admet-3091	37	40	applications	application	NOUN
admet-3091	37	41	[	[	X
admet-3091	37	42	2	2	NUM
admet-3091	37	43	]	]	PUNCT
admet-3091	37	44	.	.	PUNCT
admet-3091	38	1	protein	protein	NOUN
admet-3091	38	2	and	and	CCONJ
admet-3091	38	3	peptide	peptide	NOUN
admet-3091	38	4	-	-	PUNCT
admet-3091	38	5	based	base	VERB
admet-3091	38	6	drugs	drug	NOUN
admet-3091	38	7	are	be	AUX
admet-3091	38	8	considered	consider	VERB
admet-3091	38	9	among	among	ADP
admet-3091	38	10	the	the	DET
admet-3091	38	11	most	most	ADV
admet-3091	38	12	effective	effective	ADJ
admet-3091	38	13	therapeutic	therapeutic	ADJ
admet-3091	38	14	agents	agent	NOUN
admet-3091	38	15	due	due	ADP
admet-3091	38	16	to	to	ADP
admet-3091	38	17	their	their	PRON
admet-3091	38	18	high	high	ADJ
admet-3091	38	19	specificity	specificity	NOUN
admet-3091	38	20	and	and	CCONJ
admet-3091	38	21	strong	strong	ADJ
admet-3091	38	22	affinity	affinity	NOUN
admet-3091	38	23	for	for	ADP
admet-3091	38	24	biological	biological	ADJ
admet-3091	38	25	targets	target	NOUN
admet-3091	38	26	.	.	PUNCT
admet-3091	39	1	however	however	ADV
admet-3091	39	2	,	,	PUNCT
admet-3091	39	3	therapeutic	therapeutic	ADJ
admet-3091	39	4	peptides	peptide	NOUN
admet-3091	39	5	face	face	VERB
admet-3091	39	6	inherent	inherent	ADJ
admet-3091	39	7	delivery	delivery	NOUN
admet-3091	39	8	challenges	challenge	NOUN
admet-3091	39	9	due	due	ADP
admet-3091	39	10	to	to	ADP
admet-3091	39	11	their	their	PRON
admet-3091	39	12	short	short	ADJ
admet-3091	39	13	half	half	ADJ
admet-3091	39	14	-	-	PUNCT
admet-3091	39	15	lives	life	NOUN
admet-3091	39	16	(	(	PUNCT
admet-3091	39	17	<	<	X
admet-3091	39	18	30	30	NUM
admet-3091	39	19	minutes	minute	NOUN
admet-3091	39	20	for	for	ADP
admet-3091	39	21	many	many	ADJ
admet-3091	39	22	)	)	PUNCT
admet-3091	39	23	,	,	PUNCT
admet-3091	39	24	susceptibility	susceptibility	NOUN
admet-3091	39	25	to	to	PART
admet-3091	39	26	proteolysis	proteolysis	NOUN
admet-3091	39	27	,	,	PUNCT
admet-3091	39	28	and	and	CCONJ
admet-3091	39	29	limited	limited	ADJ
admet-3091	39	30	membrane	membrane	NOUN
admet-3091	39	31	permeability	permeability	NOUN
admet-3091	39	32	.	.	PUNCT
admet-3091	40	1	plga	plga	NOUN
admet-3091	40	2	-	-	PUNCT
admet-3091	40	3	based	base	VERB
admet-3091	40	4	formulations	formulation	NOUN
admet-3091	40	5	offer	offer	VERB
admet-3091	40	6	significant	significant	ADJ
admet-3091	40	7	advantages	advantage	NOUN
admet-3091	40	8	for	for	ADP
admet-3091	40	9	peptide	peptide	NOUN
admet-3091	40	10	therapeutics	therapeutic	NOUN
admet-3091	40	11	,	,	PUNCT
admet-3091	40	12	which	which	PRON
admet-3091	40	13	often	often	ADV
admet-3091	40	14	suffer	suffer	VERB
admet-3091	40	15	from	from	ADP
admet-3091	40	16	poor	poor	ADJ
admet-3091	40	17	bioavailability	bioavailability	NOUN
admet-3091	40	18	,	,	PUNCT
admet-3091	40	19	rapid	rapid	ADJ
admet-3091	40	20	clearance	clearance	NOUN
admet-3091	40	21	,	,	PUNCT
admet-3091	40	22	and	and	CCONJ
admet-3091	40	23	enzymatic	enzymatic	ADJ
admet-3091	40	24	degradation	degradation	NOUN
admet-3091	40	25	when	when	SCONJ
admet-3091	40	26	administered	administer	VERB
admet-3091	40	27	through	through	ADP
admet-3091	40	28	conventional	conventional	ADJ
admet-3091	40	29	routes	route	NOUN
admet-3091	40	30	[	[	X
admet-3091	40	31	4	4	NUM
admet-3091	40	32	]	]	PUNCT
admet-3091	40	33	.	.	PUNCT
admet-3091	41	1	the	the	DET
admet-3091	41	2	ability	ability	NOUN
admet-3091	41	3	to	to	PART
admet-3091	41	4	encapsulate	encapsulate	VERB
admet-3091	41	5	peptides	peptide	NOUN
admet-3091	41	6	within	within	ADP
admet-3091	41	7	plga	plga	NOUN
admet-3091	41	8	nanoparticles	nanoparticle	NOUN
admet-3091	41	9	and	and	CCONJ
admet-3091	41	10	microparticles	microparticle	NOUN
admet-3091	41	11	enables	enable	VERB
admet-3091	41	12	sustained	sustain	VERB
admet-3091	41	13	release	release	NOUN
admet-3091	41	14	over	over	ADP
admet-3091	41	15	days	day	NOUN
admet-3091	41	16	to	to	ADP
admet-3091	41	17	months	month	NOUN
admet-3091	41	18	,	,	PUNCT
admet-3091	41	19	thereby	thereby	ADV
admet-3091	41	20	reducing	reduce	VERB
admet-3091	41	21	dosing	dose	VERB
admet-3091	41	22	frequency	frequency	NOUN
admet-3091	41	23	and	and	CCONJ
admet-3091	41	24	improving	improve	VERB
admet-3091	41	25	patient	patient	ADJ
admet-3091	41	26	compliance	compliance	NOUN
admet-3091	41	27	.	.	PUNCT
admet-3091	42	1	nanoparticles	nanoparticle	NOUN
admet-3091	42	2	(	(	PUNCT
admet-3091	42	3	<	<	X
admet-3091	42	4	1	1	NUM
admet-3091	42	5	µm	µm	NOUN
admet-3091	42	6	)	)	PUNCT
admet-3091	42	7	excel	excel	VERB
admet-3091	42	8	at	at	ADP
admet-3091	42	9	systemic	systemic	ADJ
admet-3091	42	10	delivery	delivery	NOUN
admet-3091	42	11	due	due	ADP
admet-3091	42	12	to	to	ADP
admet-3091	42	13	enhanced	enhanced	ADJ
admet-3091	42	14	permeation	permeation	NOUN
admet-3091	42	15	and	and	CCONJ
admet-3091	42	16	retention	retention	NOUN
admet-3091	42	17	,	,	PUNCT
admet-3091	42	18	while	while	SCONJ
admet-3091	42	19	microparticles	microparticle	NOUN
admet-3091	42	20	(	(	PUNCT
admet-3091	42	21	1	1	NUM
admet-3091	42	22	to	to	PART
admet-3091	42	23	100	100	NUM
admet-3091	42	24	µm	µm	NOUN
admet-3091	42	25	)	)	PUNCT
admet-3091	42	26	serve	serve	VERB
admet-3091	42	27	as	as	ADP
admet-3091	42	28	injectable	injectable	ADJ
admet-3091	42	29	depots	depot	NOUN
admet-3091	42	30	for	for	ADP
admet-3091	42	31	prolonged	prolonged	ADJ
admet-3091	42	32	action	action	NOUN
admet-3091	42	33	.	.	PUNCT
admet-3091	43	1	indeed	indeed	ADV
admet-3091	43	2	,	,	PUNCT
admet-3091	43	3	plga	plga	NOUN
admet-3091	43	4	microparticles	microparticle	NOUN
admet-3091	43	5	offer	offer	VERB
admet-3091	43	6	several	several	ADJ
admet-3091	43	7	advantages	advantage	NOUN
admet-3091	43	8	over	over	ADP
admet-3091	43	9	conventional	conventional	ADJ
admet-3091	43	10	drug	drug	NOUN
admet-3091	43	11	delivery	delivery	NOUN
admet-3091	43	12	systems	system	NOUN
admet-3091	43	13	.	.	PUNCT
admet-3091	44	1	these	these	PRON
admet-3091	44	2	include	include	VERB
admet-3091	44	3	:	:	PUNCT
admet-3091	44	4	(	(	PUNCT
admet-3091	44	5	1	1	X
admet-3091	44	6	)	)	PUNCT
admet-3091	44	7	the	the	DET
admet-3091	44	8	ability	ability	NOUN
admet-3091	44	9	to	to	PART
admet-3091	44	10	tailor	tailor	VERB
admet-3091	44	11	the	the	DET
admet-3091	44	12	rate	rate	NOUN
admet-3091	44	13	and	and	CCONJ
admet-3091	44	14	duration	duration	NOUN
admet-3091	44	15	of	of	ADP
admet-3091	44	16	drug	drug	NOUN
admet-3091	44	17	release	release	NOUN
admet-3091	44	18	by	by	ADP
admet-3091	44	19	modifying	modify	VERB
admet-3091	44	20	the	the	DET
admet-3091	44	21	polymer	polymer	NOUN
admet-3091	44	22	type	type	NOUN
admet-3091	44	23	and	and	CCONJ
admet-3091	44	24	fabrication	fabrication	NOUN
admet-3091	44	25	methods	method	NOUN
admet-3091	44	26	,	,	PUNCT
admet-3091	44	27	(	(	PUNCT
admet-3091	44	28	2	2	X
admet-3091	44	29	)	)	PUNCT
admet-3091	44	30	greater	great	ADJ
admet-3091	44	31	physical	physical	ADJ
admet-3091	44	32	and	and	CCONJ
admet-3091	44	33	chemical	chemical	NOUN
admet-3091	44	34	stability	stability	NOUN
admet-3091	44	35	compared	compare	VERB
admet-3091	44	36	to	to	ADP
admet-3091	44	37	other	other	ADJ
admet-3091	44	38	delivery	delivery	NOUN
admet-3091	44	39	systems	system	NOUN
admet-3091	44	40	such	such	ADJ
admet-3091	44	41	as	as	ADP
admet-3091	44	42	liposomes	liposome	NOUN
admet-3091	44	43	,	,	PUNCT
admet-3091	44	44	and	and	CCONJ
admet-3091	44	45	(	(	PUNCT
admet-3091	44	46	3	3	X
admet-3091	44	47	)	)	PUNCT
admet-3091	44	48	reduced	reduce	VERB
admet-3091	44	49	drug	drug	NOUN
admet-3091	44	50	dosing	dose	VERB
admet-3091	44	51	due	due	ADP
admet-3091	44	52	to	to	ADP
admet-3091	44	53	enhanced	enhanced	ADJ
admet-3091	44	54	delivery	delivery	NOUN
admet-3091	44	55	efficiency	efficiency	NOUN
admet-3091	44	56	.	.	PUNCT
admet-3091	45	1	in	in	ADP
admet-3091	45	2	recent	recent	ADJ
admet-3091	45	3	years	year	NOUN
admet-3091	45	4	,	,	PUNCT
admet-3091	45	5	long	long	ADV
admet-3091	45	6	-	-	PUNCT
admet-3091	45	7	acting	act	VERB
admet-3091	45	8	injectable	injectable	NOUN
admet-3091	45	9	(	(	PUNCT
admet-3091	45	10	lai	lai	PROPN
admet-3091	45	11	)	)	PUNCT
admet-3091	45	12	microspheres	microsphere	NOUN
admet-3091	45	13	have	have	AUX
admet-3091	45	14	gained	gain	VERB
admet-3091	45	15	significant	significant	ADJ
admet-3091	45	16	attention	attention	NOUN
admet-3091	45	17	for	for	ADP
admet-3091	45	18	the	the	DET
admet-3091	45	19	delivery	delivery	NOUN
admet-3091	45	20	of	of	ADP
admet-3091	45	21	therapeutic	therapeutic	ADJ
admet-3091	45	22	proteins	protein	NOUN
admet-3091	45	23	and	and	CCONJ
admet-3091	45	24	peptides	peptide	NOUN
admet-3091	45	25	.	.	PUNCT
admet-3091	46	1	their	their	PRON
admet-3091	46	2	high	high	ADJ
admet-3091	46	3	drug	drug	NOUN
admet-3091	46	4	-	-	PUNCT
admet-3091	46	5	loading	loading	NOUN
admet-3091	46	6	capacity	capacity	NOUN
admet-3091	46	7	and	and	CCONJ
admet-3091	46	8	potential	potential	NOUN
admet-3091	46	9	to	to	PART
admet-3091	46	10	provide	provide	VERB
admet-3091	46	11	sustained	sustained	ADJ
admet-3091	46	12	release	release	NOUN
admet-3091	46	13	over	over	ADP
admet-3091	46	14	extended	extend	VERB
admet-3091	46	15	periods	period	NOUN
admet-3091	46	16	make	make	VERB
admet-3091	46	17	them	they	PRON
admet-3091	46	18	particularly	particularly	ADV
admet-3091	46	19	suitable	suitable	ADJ
admet-3091	46	20	for	for	ADP
admet-3091	46	21	chronic	chronic	ADJ
admet-3091	46	22	therapies	therapy	NOUN
admet-3091	46	23	.	.	PUNCT
admet-3091	47	1	key	key	ADJ
admet-3091	47	2	advantages	advantage	NOUN
admet-3091	47	3	of	of	ADP
admet-3091	47	4	lai	lai	PROPN
admet-3091	47	5	microspheres	microsphere	NOUN
admet-3091	47	6	include	include	VERB
admet-3091	47	7	improved	improve	VERB
admet-3091	47	8	drug	drug	NOUN
admet-3091	47	9	stability	stability	NOUN
admet-3091	47	10	and	and	CCONJ
admet-3091	47	11	bioavailability	bioavailability	NOUN
admet-3091	47	12	,	,	PUNCT
admet-3091	47	13	enhanced	enhance	VERB
admet-3091	47	14	therapeutic	therapeutic	ADJ
admet-3091	47	15	efficacy	efficacy	NOUN
admet-3091	47	16	,	,	PUNCT
admet-3091	47	17	and	and	CCONJ
admet-3091	47	18	reduced	reduce	VERB
admet-3091	47	19	dosing	dose	VERB
admet-3091	47	20	frequency	frequency	NOUN
admet-3091	47	21	.	.	PUNCT
admet-3091	48	1	more	more	ADJ
admet-3091	48	2	than	than	ADP
admet-3091	48	3	20	20	NUM
admet-3091	48	4	fda	fda	PROPN
admet-3091	48	5	-	-	PUNCT
admet-3091	48	6	approved	approve	VERB
admet-3091	48	7	plga	plga	NOUN
admet-3091	48	8	formulations	formulation	NOUN
admet-3091	48	9	have	have	AUX
admet-3091	48	10	demonstrated	demonstrate	VERB
admet-3091	48	11	clinical	clinical	ADJ
admet-3091	48	12	viability	viability	NOUN
admet-3091	48	13	[	[	X
admet-3091	48	14	2,5	2,5	NUM
admet-3091	48	15	]	]	PUNCT
admet-3091	48	16	.	.	PUNCT
admet-3091	49	1	admet	admet	PROPN
admet-3091	49	2	&	&	CCONJ
admet-3091	49	3	dmpk	dmpk	PROPN
admet-3091	49	4	00(0	00(0	PROPN
admet-3091	49	5	)	)	PUNCT
admet-3091	49	6	(	(	PUNCT
admet-3091	49	7	2025	2025	NUM
admet-3091	49	8	)	)	PUNCT
admet-3091	49	9	3091	3091	NUM
admet-3091	49	10	plga	plga	NOUN
admet-3091	49	11	nanoparticles	nanoparticle	NOUN
admet-3091	49	12	and	and	CCONJ
admet-3091	49	13	microparticles	microparticle	NOUN
admet-3091	49	14	for	for	ADP
admet-3091	49	15	peptide	peptide	ADJ
admet-3091	49	16	delivery	delivery	NOUN
admet-3091	49	17	doi	doi	NOUN
admet-3091	49	18	:	:	PUNCT
admet-3091	49	19	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	49	20	3	3	NUM
admet-3091	49	21	however	however	ADV
admet-3091	49	22	,	,	PUNCT
admet-3091	49	23	achieving	achieve	VERB
admet-3091	49	24	optimal	optimal	ADJ
admet-3091	49	25	release	release	NOUN
admet-3091	49	26	kinetics	kinetic	NOUN
admet-3091	49	27	requires	require	VERB
admet-3091	49	28	balancing	balance	VERB
admet-3091	49	29	competing	compete	VERB
admet-3091	49	30	factors	factor	NOUN
admet-3091	49	31	:	:	PUNCT
admet-3091	49	32	excessive	excessive	ADJ
admet-3091	49	33	initial	initial	ADJ
admet-3091	49	34	burst	burst	ADJ
admet-3091	49	35	release	release	NOUN
admet-3091	49	36	risks	risk	NOUN
admet-3091	49	37	toxicity	toxicity	NOUN
admet-3091	49	38	,	,	PUNCT
admet-3091	49	39	while	while	SCONJ
admet-3091	49	40	delayed	delay	VERB
admet-3091	49	41	erosion	erosion	NOUN
admet-3091	49	42	phases	phase	NOUN
admet-3091	49	43	may	may	AUX
admet-3091	49	44	undermine	undermine	VERB
admet-3091	49	45	therapeutic	therapeutic	ADJ
admet-3091	49	46	efficacy	efficacy	NOUN
admet-3091	49	47	.	.	PUNCT
admet-3091	50	1	the	the	DET
admet-3091	50	2	controlled	control	VERB
admet-3091	50	3	release	release	NOUN
admet-3091	50	4	of	of	ADP
admet-3091	50	5	peptides	peptide	NOUN
admet-3091	50	6	from	from	ADP
admet-3091	50	7	plga	plga	NOUN
admet-3091	50	8	systems	system	NOUN
admet-3091	50	9	involves	involve	VERB
admet-3091	50	10	complex	complex	ADJ
admet-3091	50	11	mechanisms	mechanism	NOUN
admet-3091	50	12	,	,	PUNCT
admet-3091	50	13	including	include	VERB
admet-3091	50	14	diffusion	diffusion	NOUN
admet-3091	50	15	through	through	ADP
admet-3091	50	16	waterfilled	waterfille	VERB
admet-3091	50	17	pores	pore	NOUN
admet-3091	50	18	,	,	PUNCT
admet-3091	50	19	polymer	polymer	NOUN
admet-3091	50	20	matrix	matrix	NOUN
admet-3091	50	21	erosion	erosion	NOUN
admet-3091	50	22	,	,	PUNCT
admet-3091	50	23	and	and	CCONJ
admet-3091	50	24	swelling	swell	VERB
admet-3091	50	25	-	-	PUNCT
admet-3091	50	26	induced	induce	VERB
admet-3091	50	27	drug	drug	NOUN
admet-3091	50	28	liberation	liberation	NOUN
admet-3091	50	29	[	[	X
admet-3091	50	30	1,6,7	1,6,7	NUM
admet-3091	50	31	]	]	PUNCT
admet-3091	50	32	.	.	PUNCT
admet-3091	51	1	understanding	understand	VERB
admet-3091	51	2	these	these	DET
admet-3091	51	3	release	release	NOUN
admet-3091	51	4	mechanisms	mechanism	NOUN
admet-3091	51	5	and	and	CCONJ
admet-3091	51	6	their	their	PRON
admet-3091	51	7	controlling	control	VERB
admet-3091	51	8	factors	factor	NOUN
admet-3091	51	9	is	be	AUX
admet-3091	51	10	crucial	crucial	ADJ
admet-3091	51	11	for	for	ADP
admet-3091	51	12	optimizing	optimize	VERB
admet-3091	51	13	therapeutic	therapeutic	ADJ
admet-3091	51	14	outcomes	outcome	NOUN
admet-3091	51	15	and	and	CCONJ
admet-3091	51	16	developing	develop	VERB
admet-3091	51	17	clinically	clinically	ADV
admet-3091	51	18	viable	viable	ADJ
admet-3091	51	19	formulations	formulation	NOUN
admet-3091	51	20	[	[	X
admet-3091	51	21	2	2	NUM
admet-3091	51	22	]	]	PUNCT
admet-3091	51	23	.	.	PUNCT
admet-3091	52	1	this	this	DET
admet-3091	52	2	review	review	NOUN
admet-3091	52	3	summarizes	summarize	VERB
admet-3091	52	4	current	current	ADJ
admet-3091	52	5	knowledge	knowledge	NOUN
admet-3091	52	6	on	on	ADP
admet-3091	52	7	peptide	peptide	ADJ
admet-3091	52	8	release	release	NOUN
admet-3091	52	9	from	from	ADP
admet-3091	52	10	plga	plga	NOUN
admet-3091	52	11	nanoand	nanoand	NOUN
admet-3091	52	12	microparticles	microparticle	NOUN
admet-3091	52	13	,	,	PUNCT
admet-3091	52	14	examining	examine	VERB
admet-3091	52	15	the	the	DET
admet-3091	52	16	fundamental	fundamental	ADJ
admet-3091	52	17	mechanisms	mechanism	NOUN
admet-3091	52	18	,	,	PUNCT
admet-3091	52	19	formulation	formulation	NOUN
admet-3091	52	20	strategies	strategy	NOUN
admet-3091	52	21	,	,	PUNCT
admet-3091	52	22	and	and	CCONJ
admet-3091	52	23	factors	factor	NOUN
admet-3091	52	24	influencing	influence	VERB
admet-3091	52	25	release	release	NOUN
admet-3091	52	26	kinetics	kinetic	NOUN
admet-3091	52	27	.	.	PUNCT
admet-3091	53	1	by	by	ADP
admet-3091	53	2	integrating	integrate	VERB
admet-3091	53	3	fundamental	fundamental	ADJ
admet-3091	53	4	principles	principle	NOUN
admet-3091	53	5	with	with	ADP
admet-3091	53	6	emerging	emerge	VERB
admet-3091	53	7	technologies	technology	NOUN
admet-3091	53	8	,	,	PUNCT
admet-3091	53	9	this	this	DET
admet-3091	53	10	work	work	NOUN
admet-3091	53	11	provides	provide	VERB
admet-3091	53	12	a	a	DET
admet-3091	53	13	framework	framework	NOUN
admet-3091	53	14	for	for	ADP
admet-3091	53	15	designing	design	VERB
admet-3091	53	16	next	next	ADJ
admet-3091	53	17	-	-	PUNCT
admet-3091	53	18	generation	generation	NOUN
admet-3091	53	19	plga	plga	NOUN
admet-3091	53	20	delivery	delivery	NOUN
admet-3091	53	21	systems	system	NOUN
admet-3091	53	22	optimized	optimize	VERB
admet-3091	53	23	for	for	ADP
admet-3091	53	24	precision	precision	NOUN
admet-3091	53	25	peptide	peptide	NOUN
admet-3091	53	26	therapeutics	therapeutic	NOUN
admet-3091	53	27	.	.	PUNCT
admet-3091	54	1	factors	factor	NOUN
admet-3091	54	2	controlling	control	VERB
admet-3091	54	3	peptide	peptide	ADJ
admet-3091	54	4	release	release	NOUN
admet-3091	54	5	in	in	ADP
admet-3091	54	6	this	this	DET
admet-3091	54	7	section	section	NOUN
admet-3091	54	8	,	,	PUNCT
admet-3091	54	9	the	the	DET
admet-3091	54	10	main	main	ADJ
admet-3091	54	11	factors	factor	NOUN
admet-3091	54	12	that	that	PRON
admet-3091	54	13	influence	influence	VERB
admet-3091	54	14	the	the	DET
admet-3091	54	15	peptide	peptide	NOUN
admet-3091	54	16	release	release	NOUN
admet-3091	54	17	profile	profile	NOUN
admet-3091	54	18	from	from	ADP
admet-3091	54	19	plga	plga	NOUN
admet-3091	54	20	nanoand	nanoand	NOUN
admet-3091	54	21	microparticles	microparticle	NOUN
admet-3091	54	22	are	be	AUX
admet-3091	54	23	discussed	discuss	VERB
admet-3091	54	24	.	.	PUNCT
admet-3091	55	1	these	these	DET
admet-3091	55	2	factors	factor	NOUN
admet-3091	55	3	include	include	VERB
admet-3091	55	4	plga	plga	VERB
admet-3091	55	5	molecular	molecular	ADJ
admet-3091	55	6	weight	weight	NOUN
admet-3091	55	7	,	,	PUNCT
admet-3091	55	8	monomer	monomer	NOUN
admet-3091	55	9	ratio	ratio	NOUN
admet-3091	55	10	,	,	PUNCT
admet-3091	55	11	particle	particle	NOUN
admet-3091	55	12	size	size	NOUN
admet-3091	55	13	,	,	PUNCT
admet-3091	55	14	endgroup	endgroup	NOUN
admet-3091	55	15	,	,	PUNCT
admet-3091	55	16	concentration	concentration	NOUN
admet-3091	55	17	,	,	PUNCT
admet-3091	55	18	peptide	peptide	NOUN
admet-3091	55	19	properties	property	NOUN
admet-3091	55	20	,	,	PUNCT
admet-3091	55	21	drug	drug	NOUN
admet-3091	55	22	loading	loading	NOUN
admet-3091	55	23	,	,	PUNCT
admet-3091	55	24	and	and	CCONJ
admet-3091	55	25	additives	additive	NOUN
admet-3091	55	26	and	and	CCONJ
admet-3091	55	27	excipients	excipient	NOUN
admet-3091	55	28	.	.	PUNCT
admet-3091	56	1	figure	figure	NOUN
admet-3091	56	2	1	1	NUM
admet-3091	56	3	summarizes	summarize	NOUN
admet-3091	56	4	the	the	DET
admet-3091	56	5	role	role	NOUN
admet-3091	56	6	of	of	ADP
admet-3091	56	7	these	these	DET
admet-3091	56	8	factors	factor	NOUN
admet-3091	56	9	on	on	ADP
admet-3091	56	10	peptide	peptide	ADJ
admet-3091	56	11	release	release	NOUN
admet-3091	56	12	.	.	PUNCT
admet-3091	57	1	figure	figure	NOUN
admet-3091	57	2	1	1	NUM
admet-3091	57	3	.	.	PUNCT
admet-3091	58	1	factors	factor	NOUN
admet-3091	58	2	controlling	control	VERB
admet-3091	58	3	peptide	peptide	ADJ
admet-3091	58	4	release	release	NOUN
admet-3091	58	5	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	58	6	m.	m.	PROPN
admet-3091	58	7	eshaghi	eshaghi	PROPN
admet-3091	58	8	et	et	PROPN
admet-3091	58	9	al	al	PROPN
admet-3091	58	10	.	.	PROPN
admet-3091	58	11	admet	admet	PROPN
admet-3091	58	12	&	&	CCONJ
admet-3091	58	13	dmpk	dmpk	PROPN
admet-3091	58	14	00(0	00(0	PROPN
admet-3091	58	15	)	)	PUNCT
admet-3091	58	16	(	(	PUNCT
admet-3091	58	17	2025	2025	NUM
admet-3091	58	18	)	)	PUNCT
admet-3091	58	19	3091	3091	NUM
admet-3091	58	20	4	4	NUM
admet-3091	58	21	molecular	molecular	ADJ
admet-3091	58	22	weight	weight	NOUN
admet-3091	58	23	the	the	DET
admet-3091	58	24	molecular	molecular	ADJ
admet-3091	58	25	weight	weight	NOUN
admet-3091	58	26	of	of	ADP
admet-3091	58	27	plga	plga	NOUN
admet-3091	58	28	significantly	significantly	ADV
admet-3091	58	29	influences	influence	VERB
admet-3091	58	30	peptide	peptide	NOUN
admet-3091	58	31	release	release	NOUN
admet-3091	58	32	kinetics	kinetic	NOUN
admet-3091	58	33	through	through	ADP
admet-3091	58	34	its	its	PRON
admet-3091	58	35	impact	impact	NOUN
admet-3091	58	36	on	on	ADP
admet-3091	58	37	polymer	polymer	NOUN
admet-3091	58	38	degradation	degradation	NOUN
admet-3091	58	39	rates	rate	NOUN
admet-3091	58	40	and	and	CCONJ
admet-3091	58	41	matrix	matrix	NOUN
admet-3091	58	42	porosity	porosity	NOUN
admet-3091	58	43	.	.	PUNCT
admet-3091	59	1	lower	low	ADJ
admet-3091	59	2	molecular	molecular	ADJ
admet-3091	59	3	weight	weight	NOUN
admet-3091	59	4	plga	plga	NOUN
admet-3091	59	5	exhibits	exhibit	VERB
admet-3091	59	6	faster	fast	ADJ
admet-3091	59	7	hydrolytic	hydrolytic	ADJ
admet-3091	59	8	degradation	degradation	NOUN
admet-3091	59	9	,	,	PUNCT
admet-3091	59	10	leading	lead	VERB
admet-3091	59	11	to	to	ADP
admet-3091	59	12	increased	increase	VERB
admet-3091	59	13	water	water	NOUN
admet-3091	59	14	uptake	uptake	NOUN
admet-3091	59	15	and	and	CCONJ
admet-3091	59	16	accelerated	accelerate	VERB
admet-3091	59	17	peptide	peptide	ADJ
admet-3091	59	18	diffusion	diffusion	NOUN
admet-3091	59	19	[	[	X
admet-3091	59	20	8	8	NUM
admet-3091	59	21	-	-	SYM
admet-3091	59	22	10	10	NUM
admet-3091	59	23	]	]	PUNCT
admet-3091	59	24	.	.	PUNCT
admet-3091	60	1	in	in	ADP
admet-3091	60	2	a	a	DET
admet-3091	60	3	study	study	NOUN
admet-3091	60	4	of	of	ADP
admet-3091	60	5	leuprolide	leuprolide	NOUN
admet-3091	60	6	acetate	acetate	NOUN
admet-3091	60	7	release	release	NOUN
admet-3091	60	8	from	from	ADP
admet-3091	60	9	in	in	ADP
admet-3091	60	10	situ	situ	ADJ
admet-3091	60	11	forming	form	VERB
admet-3091	60	12	microparticles	microparticle	NOUN
admet-3091	60	13	,	,	PUNCT
admet-3091	60	14	plga	plga	VERB
admet-3091	60	15	with	with	ADP
admet-3091	60	16	molecular	molecular	ADJ
admet-3091	60	17	weight	weight	NOUN
admet-3091	60	18	16,000	16,000	NUM
admet-3091	60	19	da	da	X
admet-3091	60	20	(	(	PUNCT
admet-3091	60	21	rg	rg	NOUN
admet-3091	60	22	502	502	NUM
admet-3091	60	23	)	)	PUNCT
admet-3091	60	24	demonstrated	demonstrate	VERB
admet-3091	60	25	49.3	49.3	NUM
admet-3091	60	26	%	%	NOUN
admet-3091	60	27	burst	burst	NOUN
admet-3091	60	28	release	release	NOUN
admet-3091	60	29	within	within	ADP
admet-3091	60	30	24	24	NUM
admet-3091	60	31	hours	hour	NOUN
admet-3091	60	32	compared	compare	VERB
admet-3091	60	33	to	to	ADP
admet-3091	60	34	24.1	24.1	NUM
admet-3091	60	35	%	%	NOUN
admet-3091	60	36	for	for	ADP
admet-3091	60	37	higher	high	ADJ
admet-3091	60	38	molecular	molecular	ADJ
admet-3091	60	39	weight	weight	NOUN
admet-3091	60	40	plga	plga	NOUN
admet-3091	60	41	(	(	PUNCT
admet-3091	60	42	rg	rg	PROPN
admet-3091	60	43	504	504	NUM
admet-3091	60	44	,	,	PUNCT
admet-3091	60	45	56,500	56,500	NUM
admet-3091	60	46	da	da	NOUN
admet-3091	60	47	)	)	PUNCT
admet-3091	60	48	.	.	PUNCT
admet-3091	61	1	studies	study	NOUN
admet-3091	61	2	have	have	AUX
admet-3091	61	3	shown	show	VERB
admet-3091	61	4	that	that	SCONJ
admet-3091	61	5	increasing	increase	VERB
admet-3091	61	6	amounts	amount	NOUN
admet-3091	61	7	of	of	ADP
admet-3091	61	8	low	low	ADJ
admet-3091	61	9	-	-	PUNCT
admet-3091	61	10	molecular	molecular	ADJ
admet-3091	61	11	-	-	PUNCT
admet-3091	61	12	weight	weight	NOUN
admet-3091	61	13	fractions	fraction	NOUN
admet-3091	61	14	in	in	ADP
admet-3091	61	15	plga	plga	NOUN
admet-3091	61	16	lead	lead	NOUN
admet-3091	61	17	to	to	ADP
admet-3091	61	18	higher	high	ADJ
admet-3091	61	19	initial	initial	ADJ
admet-3091	61	20	burst	burst	ADJ
admet-3091	61	21	release	release	NOUN
admet-3091	61	22	,	,	PUNCT
admet-3091	61	23	indicating	indicate	VERB
admet-3091	61	24	that	that	SCONJ
admet-3091	61	25	both	both	PRON
admet-3091	61	26	average	average	ADJ
admet-3091	61	27	molecular	molecular	ADJ
admet-3091	61	28	weight	weight	NOUN
admet-3091	61	29	and	and	CCONJ
admet-3091	61	30	polydispersity	polydispersity	NOUN
admet-3091	61	31	affect	affect	VERB
admet-3091	61	32	release	release	NOUN
admet-3091	61	33	profiles	profile	NOUN
admet-3091	61	34	.	.	PUNCT
admet-3091	62	1	this	this	DET
admet-3091	62	2	phenomenon	phenomenon	NOUN
admet-3091	62	3	occurs	occur	VERB
admet-3091	62	4	because	because	SCONJ
admet-3091	62	5	low	low	ADJ
admet-3091	62	6	-	-	PUNCT
admet-3091	62	7	molecular	molecular	ADJ
admet-3091	62	8	-	-	PUNCT
admet-3091	62	9	weight	weight	NOUN
admet-3091	62	10	chains	chain	NOUN
admet-3091	62	11	degrade	degrade	VERB
admet-3091	62	12	more	more	ADV
admet-3091	62	13	rapidly	rapidly	ADV
admet-3091	62	14	,	,	PUNCT
admet-3091	62	15	creating	create	VERB
admet-3091	62	16	preferential	preferential	ADJ
admet-3091	62	17	pathways	pathway	NOUN
admet-3091	62	18	for	for	ADP
admet-3091	62	19	peptide	peptide	NOUN
admet-3091	62	20	diffusion	diffusion	NOUN
admet-3091	62	21	[	[	X
admet-3091	62	22	10	10	NUM
admet-3091	62	23	-	-	SYM
admet-3091	62	24	12	12	NUM
admet-3091	62	25	]	]	PUNCT
admet-3091	62	26	.	.	PUNCT
admet-3091	63	1	conversely	conversely	ADV
admet-3091	63	2	,	,	PUNCT
admet-3091	63	3	higher	high	ADJ
admet-3091	63	4	molecular	molecular	ADJ
admet-3091	63	5	weight	weight	NOUN
admet-3091	63	6	plga	plga	NOUN
admet-3091	63	7	extends	extends	AUX
admet-3091	63	8	release	release	VERB
admet-3091	63	9	duration	duration	NOUN
admet-3091	63	10	by	by	ADP
admet-3091	63	11	slowing	slow	VERB
admet-3091	63	12	degradation	degradation	NOUN
admet-3091	63	13	and	and	CCONJ
admet-3091	63	14	reducing	reduce	VERB
admet-3091	63	15	matrix	matrix	NOUN
admet-3091	63	16	porosity	porosity	NOUN
admet-3091	63	17	.	.	PUNCT
admet-3091	64	1	a	a	DET
admet-3091	64	2	neutral	neutral	ADJ
admet-3091	64	3	peptide	peptide	NOUN
admet-3091	64	4	required	require	VERB
admet-3091	64	5	over	over	ADP
admet-3091	64	6	8	8	NUM
admet-3091	64	7	weeks	week	NOUN
admet-3091	64	8	for	for	ADP
admet-3091	64	9	complete	complete	ADJ
admet-3091	64	10	release	release	NOUN
admet-3091	64	11	from	from	ADP
admet-3091	64	12	ester	ester	NOUN
admet-3091	64	13	-	-	PUNCT
admet-3091	64	14	capped	cap	VERB
admet-3091	64	15	15	15	NUM
admet-3091	64	16	kda	kda	NOUN
admet-3091	64	17	plga	plga	NOUN
admet-3091	64	18	microparticles	microparticle	NOUN
admet-3091	64	19	,	,	PUNCT
admet-3091	64	20	compared	compare	VERB
admet-3091	64	21	to	to	ADP
admet-3091	64	22	13	13	NUM
admet-3091	64	23	days	day	NOUN
admet-3091	64	24	from	from	ADP
admet-3091	64	25	7	7	NUM
admet-3091	64	26	kda	kda	NOUN
admet-3091	64	27	plga	plga	NOUN
admet-3091	64	28	.	.	PUNCT
admet-3091	65	1	this	this	DET
admet-3091	65	2	delayed	delay	VERB
admet-3091	65	3	release	release	NOUN
admet-3091	65	4	results	result	NOUN
admet-3091	65	5	from	from	ADP
admet-3091	65	6	prolonged	prolonged	ADJ
admet-3091	65	7	polymer	polymer	NOUN
admet-3091	65	8	entanglement	entanglement	NOUN
admet-3091	65	9	and	and	CCONJ
admet-3091	65	10	slower	slow	ADJ
admet-3091	65	11	pore	pore	ADJ
admet-3091	65	12	formation	formation	NOUN
admet-3091	65	13	[	[	X
admet-3091	65	14	13	13	NUM
admet-3091	65	15	]	]	PUNCT
admet-3091	65	16	.	.	PUNCT
admet-3091	66	1	in	in	ADP
admet-3091	66	2	another	another	DET
admet-3091	66	3	study	study	NOUN
admet-3091	66	4	by	by	ADP
admet-3091	66	5	haim	haim	PROPN
admet-3091	66	6	zada	zada	PROPN
admet-3091	66	7	et	et	PROPN
admet-3091	66	8	al	al	PROPN
admet-3091	66	9	.	.	PUNCT
admet-3091	67	1	[	[	X
admet-3091	67	2	14	14	NUM
admet-3091	67	3	]	]	X
admet-3091	67	4	,	,	PUNCT
admet-3091	67	5	lower	low	ADJ
admet-3091	67	6	mw	mw	X
admet-3091	67	7	plga	plga	NOUN
admet-3091	67	8	(	(	PUNCT
admet-3091	67	9	75:25	75:25	NUM
admet-3091	67	10	,	,	PUNCT
admet-3091	67	11	30	30	NUM
admet-3091	67	12	kda	kda	NOUN
admet-3091	67	13	)	)	PUNCT
admet-3091	67	14	nps	nps	PROPN
admet-3091	67	15	released	release	VERB
admet-3091	67	16	trh	trh	NOUN
admet-3091	67	17	peptide	peptide	VERB
admet-3091	67	18	faster	fast	ADV
admet-3091	67	19	than	than	ADP
admet-3091	67	20	higher	high	ADJ
admet-3091	67	21	mw	mw	X
admet-3091	67	22	pla	pla	NOUN
admet-3091	67	23	(	(	PUNCT
admet-3091	67	24	55	55	NUM
admet-3091	67	25	kda	kda	NOUN
admet-3091	67	26	)	)	PUNCT
admet-3091	67	27	nps	nps	PROPN
admet-3091	67	28	,	,	PUNCT
admet-3091	67	29	consistent	consistent	ADJ
admet-3091	67	30	with	with	ADP
admet-3091	67	31	accelerated	accelerated	ADJ
admet-3091	67	32	degradation	degradation	NOUN
admet-3091	67	33	of	of	ADP
admet-3091	67	34	low	low	ADJ
admet-3091	67	35	-	-	PUNCT
admet-3091	67	36	mw	mw	NOUN
admet-3091	67	37	polymers	polymer	NOUN
admet-3091	67	38	.	.	PUNCT
admet-3091	68	1	ravivarapu	ravivarapu	PROPN
admet-3091	68	2	et	et	PROPN
admet-3091	68	3	al	al	PROPN
admet-3091	68	4	.	.	PUNCT
admet-3091	69	1	[	[	X
admet-3091	69	2	15	15	NUM
admet-3091	69	3	]	]	PUNCT
admet-3091	69	4	evaluated	evaluate	VERB
admet-3091	69	5	the	the	DET
admet-3091	69	6	release	release	NOUN
admet-3091	69	7	of	of	ADP
admet-3091	69	8	leuprolide	leuprolide	NOUN
admet-3091	69	9	acetate	acetate	NOUN
admet-3091	69	10	from	from	ADP
admet-3091	69	11	microparticles	microparticle	NOUN
admet-3091	69	12	with	with	ADP
admet-3091	69	13	various	various	ADJ
admet-3091	69	14	blends	blend	NOUN
admet-3091	69	15	of	of	ADP
admet-3091	69	16	high	high	ADJ
admet-3091	69	17	-	-	PUNCT
admet-3091	69	18	mw	mw	NOUN
admet-3091	69	19	(	(	PUNCT
admet-3091	69	20	28.3	28.3	NUM
admet-3091	69	21	kda	kda	NOUN
admet-3091	69	22	)	)	PUNCT
admet-3091	69	23	and	and	CCONJ
admet-3091	69	24	low	low	ADJ
admet-3091	69	25	-	-	PUNCT
admet-3091	69	26	mw	mw	NOUN
admet-3091	69	27	(	(	PUNCT
admet-3091	69	28	8.6	8.6	NUM
admet-3091	69	29	kda	kda	NOUN
admet-3091	69	30	)	)	PUNCT
admet-3091	69	31	plga	plga	NOUN
admet-3091	69	32	.	.	PUNCT
admet-3091	70	1	as	as	SCONJ
admet-3091	70	2	anticipated	anticipate	VERB
admet-3091	70	3	,	,	PUNCT
admet-3091	70	4	blends	blend	NOUN
admet-3091	70	5	with	with	ADP
admet-3091	70	6	higher	high	ADJ
admet-3091	70	7	ratios	ratio	NOUN
admet-3091	70	8	of	of	ADP
admet-3091	70	9	high	high	ADJ
admet-3091	70	10	-	-	PUNCT
admet-3091	70	11	mw	mw	NOUN
admet-3091	70	12	polymer	polymer	NOUN
admet-3091	70	13	exhibited	exhibit	VERB
admet-3091	70	14	slower	slow	ADJ
admet-3091	70	15	degradation	degradation	NOUN
admet-3091	70	16	rates	rate	NOUN
admet-3091	70	17	and	and	CCONJ
admet-3091	70	18	,	,	PUNCT
admet-3091	70	19	consequently	consequently	ADV
admet-3091	70	20	,	,	PUNCT
admet-3091	70	21	longer	long	ADV
admet-3091	70	22	release	release	VERB
admet-3091	70	23	periods	period	NOUN
admet-3091	70	24	.	.	PUNCT
admet-3091	71	1	monomer	monomer	NOUN
admet-3091	71	2	ratio	ratio	NOUN
admet-3091	71	3	(	(	PUNCT
admet-3091	71	4	lactide	lactide	ADV
admet-3091	71	5	:	:	PUNCT
admet-3091	71	6	glycolide	glycolide	ADJ
admet-3091	71	7	)	)	PUNCT
admet-3091	71	8	the	the	DET
admet-3091	71	9	lactic	lactic	ADJ
admet-3091	71	10	acid	acid	NOUN
admet-3091	71	11	-	-	PUNCT
admet-3091	71	12	to	to	ADP
admet-3091	71	13	-	-	PUNCT
admet-3091	71	14	glycolic	glycolic	NOUN
admet-3091	71	15	acid	acid	NOUN
admet-3091	71	16	molar	molar	NOUN
admet-3091	71	17	ratio	ratio	NOUN
admet-3091	71	18	fundamentally	fundamentally	ADV
admet-3091	71	19	determines	determine	VERB
admet-3091	71	20	plga	plga	NOUN
admet-3091	71	21	degradation	degradation	NOUN
admet-3091	71	22	rates	rate	NOUN
admet-3091	71	23	and	and	CCONJ
admet-3091	71	24	,	,	PUNCT
admet-3091	71	25	consequently	consequently	ADV
admet-3091	71	26	,	,	PUNCT
admet-3091	71	27	peptide	peptide	ADJ
admet-3091	71	28	release	release	NOUN
admet-3091	71	29	[	[	X
admet-3091	71	30	9,16	9,16	NUM
admet-3091	71	31	]	]	X
admet-3091	71	32	.	.	PUNCT
admet-3091	72	1	higher	high	ADJ
admet-3091	72	2	glycolic	glycolic	NOUN
admet-3091	72	3	acid	acid	NOUN
admet-3091	72	4	content	content	NOUN
admet-3091	72	5	increases	increase	VERB
admet-3091	72	6	polymer	polymer	NOUN
admet-3091	72	7	hydrophilicity	hydrophilicity	NOUN
admet-3091	72	8	and	and	CCONJ
admet-3091	72	9	degradation	degradation	NOUN
admet-3091	72	10	rate	rate	NOUN
admet-3091	72	11	,	,	PUNCT
admet-3091	72	12	resulting	result	VERB
admet-3091	72	13	in	in	ADP
admet-3091	72	14	faster	fast	ADJ
admet-3091	72	15	peptide	peptide	NOUN
admet-3091	72	16	release	release	NOUN
admet-3091	72	17	[	[	X
admet-3091	72	18	9	9	NUM
admet-3091	72	19	]	]	PUNCT
admet-3091	72	20	.	.	PUNCT
admet-3091	73	1	conversely	conversely	ADV
admet-3091	73	2	,	,	PUNCT
admet-3091	73	3	higher	high	ADJ
admet-3091	73	4	lactide	lactide	ADJ
admet-3091	73	5	content	content	NOUN
admet-3091	73	6	slows	slow	VERB
admet-3091	73	7	degradation	degradation	NOUN
admet-3091	73	8	due	due	ADJ
admet-3091	73	9	to	to	ADP
admet-3091	73	10	increased	increase	VERB
admet-3091	73	11	hydrophobicity	hydrophobicity	NOUN
admet-3091	73	12	and	and	CCONJ
admet-3091	73	13	crystallinity	crystallinity	NOUN
admet-3091	73	14	[	[	X
admet-3091	73	15	17	17	NUM
admet-3091	73	16	]	]	PUNCT
admet-3091	73	17	.	.	PUNCT
admet-3091	74	1	in	in	ADP
admet-3091	74	2	a	a	DET
admet-3091	74	3	comparative	comparative	ADJ
admet-3091	74	4	study	study	NOUN
admet-3091	74	5	of	of	ADP
admet-3091	74	6	anti	anti	ADJ
admet-3091	74	7	-	-	ADJ
admet-3091	74	8	angiogenic	angiogenic	ADJ
admet-3091	74	9	peptide	peptide	NOUN
admet-3091	74	10	delivery	delivery	NOUN
admet-3091	74	11	,	,	PUNCT
admet-3091	74	12	85:15	85:15	NUM
admet-3091	74	13	(	(	PUNCT
admet-3091	74	14	lactide	lactide	ADJ
admet-3091	74	15	:	:	PUNCT
admet-3091	74	16	glycolide	glycolide	ADJ
admet-3091	74	17	)	)	PUNCT
admet-3091	74	18	plga	plga	NOUN
admet-3091	74	19	microparticles	microparticle	NOUN
admet-3091	74	20	demonstrated	demonstrate	VERB
admet-3091	74	21	higher	high	ADJ
admet-3091	74	22	encapsulation	encapsulation	NOUN
admet-3091	74	23	efficiency	efficiency	NOUN
admet-3091	74	24	and	and	CCONJ
admet-3091	74	25	slower	slow	ADJ
admet-3091	74	26	degradation	degradation	NOUN
admet-3091	74	27	compared	compare	VERB
admet-3091	74	28	to	to	ADP
admet-3091	74	29	65:35	65:35	NUM
admet-3091	74	30	formulations	formulation	NOUN
admet-3091	74	31	,	,	PUNCT
admet-3091	74	32	supporting	support	VERB
admet-3091	74	33	prolonged	prolonged	ADJ
admet-3091	74	34	drug	drug	NOUN
admet-3091	74	35	release	release	NOUN
admet-3091	74	36	over	over	ADP
admet-3091	74	37	6	6	NUM
admet-3091	74	38	months	month	NOUN
admet-3091	74	39	[	[	X
admet-3091	74	40	16	16	NUM
admet-3091	74	41	]	]	PUNCT
admet-3091	74	42	.	.	PUNCT
admet-3091	75	1	kranz	kranz	PROPN
admet-3091	75	2	and	and	CCONJ
admet-3091	75	3	bodmeier	bodmeier	NOUN
admet-3091	75	4	also	also	ADV
admet-3091	75	5	examined	examine	VERB
admet-3091	75	6	the	the	DET
admet-3091	75	7	effect	effect	NOUN
admet-3091	75	8	of	of	ADP
admet-3091	75	9	polymer	polymer	NOUN
admet-3091	75	10	composition	composition	NOUN
admet-3091	75	11	(	(	PUNCT
admet-3091	75	12	lactide	lactide	ADV
admet-3091	75	13	:	:	PUNCT
admet-3091	75	14	glycolide	glycolide	ADJ
admet-3091	75	15	ratio	ratio	NOUN
admet-3091	75	16	)	)	PUNCT
admet-3091	75	17	on	on	ADP
admet-3091	75	18	peptide	peptide	ADJ
admet-3091	75	19	release	release	NOUN
admet-3091	75	20	.	.	PUNCT
admet-3091	76	1	sizeexclusion	sizeexclusion	NOUN
admet-3091	76	2	chromatography	chromatography	NOUN
admet-3091	76	3	revealed	reveal	VERB
admet-3091	76	4	that	that	SCONJ
admet-3091	76	5	plga	plga	NOUN
admet-3091	76	6	formulations	formulation	NOUN
admet-3091	76	7	(	(	PUNCT
admet-3091	76	8	rg	rg	PROPN
admet-3091	76	9	502	502	NUM
admet-3091	76	10	and	and	CCONJ
admet-3091	76	11	rg	rg	PROPN
admet-3091	76	12	503	503	NUM
admet-3091	76	13	)	)	PUNCT
admet-3091	76	14	degraded	degrade	VERB
admet-3091	76	15	more	more	ADV
admet-3091	76	16	rapidly	rapidly	ADV
admet-3091	76	17	than	than	ADP
admet-3091	76	18	pla	pla	NOUN
admet-3091	76	19	(	(	PUNCT
admet-3091	76	20	r	r	NOUN
admet-3091	76	21	203	203	NUM
admet-3091	76	22	)	)	PUNCT
admet-3091	76	23	,	,	PUNCT
admet-3091	76	24	reaching	reach	VERB
admet-3091	76	25	almost	almost	ADV
admet-3091	76	26	complete	complete	ADJ
admet-3091	76	27	degradation	degradation	NOUN
admet-3091	76	28	by	by	ADP
admet-3091	76	29	day	day	NOUN
admet-3091	76	30	28	28	NUM
admet-3091	76	31	,	,	PUNCT
admet-3091	76	32	indicating	indicate	VERB
admet-3091	76	33	accelerated	accelerate	VERB
admet-3091	76	34	polymer	polymer	NOUN
admet-3091	76	35	degradation	degradation	NOUN
admet-3091	76	36	and	and	CCONJ
admet-3091	76	37	peptide	peptide	NOUN
admet-3091	76	38	release	release	NOUN
admet-3091	76	39	at	at	ADP
admet-3091	76	40	lower	low	ADJ
admet-3091	76	41	lactide	lactide	ADV
admet-3091	76	42	:	:	PUNCT
admet-3091	76	43	glycolide	glycolide	ADJ
admet-3091	76	44	ratios	ratio	NOUN
admet-3091	77	1	[	[	X
admet-3091	77	2	11	11	NUM
admet-3091	77	3	]	]	PUNCT
admet-3091	77	4	.	.	PUNCT
admet-3091	78	1	particle	particle	NOUN
admet-3091	78	2	size	size	NOUN
admet-3091	78	3	particle	particle	NOUN
admet-3091	78	4	size	size	NOUN
admet-3091	78	5	significantly	significantly	ADV
admet-3091	78	6	influences	influence	VERB
admet-3091	78	7	release	release	NOUN
admet-3091	78	8	kinetics	kinetic	NOUN
admet-3091	78	9	by	by	ADP
admet-3091	78	10	affecting	affect	VERB
admet-3091	78	11	the	the	DET
admet-3091	78	12	surface	surface	NOUN
admet-3091	78	13	area	area	NOUN
admet-3091	78	14	-	-	PUNCT
admet-3091	78	15	to	to	ADP
admet-3091	78	16	-	-	PUNCT
admet-3091	78	17	volume	volume	NOUN
admet-3091	78	18	ratio	ratio	NOUN
admet-3091	78	19	and	and	CCONJ
admet-3091	78	20	the	the	DET
admet-3091	78	21	diffusion	diffusion	NOUN
admet-3091	78	22	path	path	NOUN
admet-3091	78	23	length	length	NOUN
admet-3091	79	1	[	[	X
admet-3091	79	2	18,19	18,19	NUM
admet-3091	79	3	]	]	X
admet-3091	79	4	.	.	PUNCT
admet-3091	80	1	smaller	small	ADJ
admet-3091	80	2	particles	particle	NOUN
admet-3091	80	3	generally	generally	ADV
admet-3091	80	4	exhibit	exhibit	VERB
admet-3091	80	5	faster	fast	ADJ
admet-3091	80	6	burst	burst	ADJ
admet-3091	80	7	release	release	NOUN
admet-3091	80	8	due	due	ADP
admet-3091	80	9	to	to	ADP
admet-3091	80	10	higher	high	ADJ
admet-3091	80	11	surface	surface	NOUN
admet-3091	80	12	area	area	NOUN
admet-3091	80	13	,	,	PUNCT
admet-3091	80	14	while	while	SCONJ
admet-3091	80	15	larger	large	ADJ
admet-3091	80	16	particles	particle	NOUN
admet-3091	80	17	provide	provide	VERB
admet-3091	80	18	more	more	ADJ
admet-3091	80	19	sustained	sustained	ADJ
admet-3091	80	20	release	release	NOUN
admet-3091	80	21	[	[	X
admet-3091	80	22	19,20	19,20	X
admet-3091	80	23	]	]	PUNCT
admet-3091	80	24	.	.	PUNCT
admet-3091	81	1	studies	study	NOUN
admet-3091	81	2	with	with	ADP
admet-3091	81	3	plga	plga	NOUN
admet-3091	81	4	microparticles	microparticle	NOUN
admet-3091	81	5	demonstrated	demonstrate	VERB
admet-3091	81	6	that	that	SCONJ
admet-3091	81	7	particles	particle	NOUN
admet-3091	81	8	smaller	small	ADJ
admet-3091	81	9	than	than	ADP
admet-3091	81	10	50	50	NUM
admet-3091	81	11	μm	μm	NOUN
admet-3091	81	12	showed	show	VERB
admet-3091	81	13	rapid	rapid	ADJ
admet-3091	81	14	diffusion	diffusion	NOUN
admet-3091	81	15	-	-	PUNCT
admet-3091	81	16	based	base	VERB
admet-3091	81	17	release	release	NOUN
admet-3091	81	18	,	,	PUNCT
admet-3091	81	19	completing	complete	VERB
admet-3091	81	20	within	within	ADP
admet-3091	81	21	2	2	NUM
admet-3091	81	22	days	day	NOUN
admet-3091	81	23	,	,	PUNCT
admet-3091	81	24	whereas	whereas	SCONJ
admet-3091	81	25	larger	large	ADJ
admet-3091	81	26	microparticles	microparticle	NOUN
admet-3091	81	27	(	(	PUNCT
admet-3091	81	28	>	>	SYM
admet-3091	81	29	50	50	NUM
admet-3091	81	30	μm	μm	NOUN
admet-3091	81	31	)	)	PUNCT
admet-3091	81	32	exhibited	exhibit	VERB
admet-3091	81	33	sustained	sustained	ADJ
admet-3091	81	34	release	release	NOUN
admet-3091	81	35	patterns	pattern	NOUN
admet-3091	81	36	continuing	continue	VERB
admet-3091	81	37	for	for	ADP
admet-3091	81	38	three	three	NUM
admet-3091	81	39	months	month	NOUN
admet-3091	82	1	[	[	X
admet-3091	82	2	17	17	NUM
admet-3091	82	3	]	]	PUNCT
admet-3091	82	4	.	.	PUNCT
admet-3091	83	1	by	by	ADP
admet-3091	83	2	adjusting	adjust	VERB
admet-3091	83	3	particle	particle	NOUN
admet-3091	83	4	porosity	porosity	NOUN
admet-3091	83	5	and	and	CCONJ
admet-3091	83	6	size	size	NOUN
admet-3091	83	7	,	,	PUNCT
admet-3091	83	8	santhosh	santhosh	PROPN
admet-3091	83	9	et	et	PROPN
admet-3091	83	10	al	al	PROPN
admet-3091	83	11	.	.	PUNCT
admet-3091	84	1	[	[	X
admet-3091	84	2	20	20	NUM
admet-3091	84	3	]	]	PUNCT
admet-3091	84	4	achieved	achieve	VERB
admet-3091	84	5	controlled	control	VERB
admet-3091	84	6	release	release	NOUN
admet-3091	84	7	rates	rate	NOUN
admet-3091	84	8	ranging	range	VERB
admet-3091	84	9	from	from	ADP
admet-3091	84	10	114.5	114.5	NUM
admet-3091	84	11	to	to	ADP
admet-3091	84	12	308.1	308.1	NUM
admet-3091	84	13	ng	ng	PROPN
admet-3091	84	14	day-1	day-1	NUM
admet-3091	84	15	,	,	PUNCT
admet-3091	84	16	with	with	ADP
admet-3091	84	17	more	more	ADV
admet-3091	84	18	porous	porous	ADJ
admet-3091	84	19	and	and	CCONJ
admet-3091	84	20	larger	large	ADJ
admet-3091	84	21	particles	particle	NOUN
admet-3091	84	22	enabling	enable	VERB
admet-3091	84	23	higher	high	ADJ
admet-3091	84	24	and	and	CCONJ
admet-3091	84	25	longerduration	longerduration	NOUN
admet-3091	84	26	release	release	NOUN
admet-3091	84	27	(	(	PUNCT
admet-3091	84	28	up	up	ADP
admet-3091	84	29	to	to	PART
admet-3091	84	30	42	42	NUM
admet-3091	84	31	days	day	NOUN
admet-3091	84	32	)	)	PUNCT
admet-3091	84	33	.	.	PUNCT
admet-3091	85	1	smaller	small	ADJ
admet-3091	85	2	porous	porous	ADJ
admet-3091	85	3	microparticles	microparticle	NOUN
admet-3091	85	4	(	(	PUNCT
admet-3091	85	5	1.43	1.43	NUM
admet-3091	85	6	µm	µm	ADP
admet-3091	85	7	average	average	ADJ
admet-3091	85	8	diameter	diameter	NOUN
admet-3091	85	9	)	)	PUNCT
admet-3091	85	10	sustained	sustain	VERB
admet-3091	85	11	neuregulin-1	neuregulin-1	NUM
admet-3091	85	12	(	(	PUNCT
admet-3091	85	13	nrg-1	nrg-1	NOUN
admet-3091	85	14	)	)	PUNCT
admet-3091	85	15	release	release	NOUN
admet-3091	85	16	for	for	ADP
admet-3091	85	17	up	up	ADP
admet-3091	85	18	to	to	PART
admet-3091	85	19	21	21	NUM
admet-3091	85	20	days	day	NOUN
admet-3091	85	21	,	,	PUNCT
admet-3091	85	22	whereas	whereas	SCONJ
admet-3091	85	23	larger	large	ADJ
admet-3091	85	24	particles	particle	NOUN
admet-3091	85	25	(	(	PUNCT
admet-3091	85	26	2.37	2.37	NUM
admet-3091	85	27	µm	µm	ADP
admet-3091	85	28	average	average	ADJ
admet-3091	85	29	diameter	diameter	NOUN
admet-3091	85	30	)	)	PUNCT
admet-3091	85	31	extended	extend	VERB
admet-3091	85	32	release	release	NOUN
admet-3091	85	33	up	up	ADP
admet-3091	85	34	to	to	PART
admet-3091	85	35	42	42	NUM
admet-3091	85	36	days	day	NOUN
admet-3091	85	37	.	.	PUNCT
admet-3091	86	1	the	the	DET
admet-3091	86	2	release	release	NOUN
admet-3091	86	3	kinetics	kinetic	NOUN
admet-3091	86	4	exhibited	exhibit	VERB
admet-3091	86	5	an	an	DET
admet-3091	86	6	initial	initial	ADJ
admet-3091	86	7	burst	burst	ADJ
admet-3091	86	8	phase	phase	NOUN
admet-3091	86	9	followed	follow	VERB
admet-3091	86	10	by	by	ADP
admet-3091	86	11	a	a	DET
admet-3091	86	12	sustained	sustained	ADJ
admet-3091	86	13	release	release	NOUN
admet-3091	86	14	plateau	plateau	NOUN
admet-3091	86	15	.	.	PUNCT
admet-3091	87	1	the	the	DET
admet-3091	87	2	larger	large	ADJ
admet-3091	87	3	particles	particle	NOUN
admet-3091	87	4	achieved	achieve	VERB
admet-3091	87	5	a	a	DET
admet-3091	87	6	daily	daily	ADJ
admet-3091	87	7	release	release	NOUN
admet-3091	87	8	rate	rate	NOUN
admet-3091	87	9	of	of	ADP
admet-3091	87	10	251.4	251.4	NUM
admet-3091	87	11	ng	ng	PROPN
admet-3091	87	12	day-1	day-1	NUM
admet-3091	87	13	in	in	ADP
admet-3091	87	14	vitro	vitro	X
admet-3091	87	15	and	and	CCONJ
admet-3091	87	16	267	267	NUM
admet-3091	87	17	±	±	NUM
admet-3091	87	18	4	4	NUM
admet-3091	87	19	ng	ng	PROPN
admet-3091	87	20	day-1	day-1	NUM
admet-3091	87	21	when	when	SCONJ
admet-3091	87	22	suspended	suspend	VERB
admet-3091	87	23	in	in	ADP
admet-3091	87	24	artificial	artificial	ADJ
admet-3091	87	25	cerebrospinal	cerebrospinal	ADJ
admet-3091	87	26	fluid	fluid	NOUN
admet-3091	87	27	(	(	PUNCT
admet-3091	87	28	acsf	acsf	PROPN
admet-3091	87	29	)	)	PUNCT
admet-3091	87	30	.	.	PUNCT
admet-3091	88	1	admet	admet	PROPN
admet-3091	88	2	&	&	CCONJ
admet-3091	88	3	dmpk	dmpk	PROPN
admet-3091	88	4	00(0	00(0	PROPN
admet-3091	88	5	)	)	PUNCT
admet-3091	88	6	(	(	PUNCT
admet-3091	88	7	2025	2025	NUM
admet-3091	88	8	)	)	PUNCT
admet-3091	88	9	3091	3091	NUM
admet-3091	88	10	plga	plga	NOUN
admet-3091	88	11	nanoparticles	nanoparticle	NOUN
admet-3091	88	12	and	and	CCONJ
admet-3091	88	13	microparticles	microparticle	NOUN
admet-3091	88	14	for	for	ADP
admet-3091	88	15	peptide	peptide	ADJ
admet-3091	88	16	delivery	delivery	NOUN
admet-3091	88	17	doi	doi	NOUN
admet-3091	88	18	:	:	PUNCT
admet-3091	88	19	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	88	20	5	5	NUM
admet-3091	88	21	for	for	ADP
admet-3091	88	22	nanoparticles	nanoparticle	NOUN
admet-3091	88	23	,	,	PUNCT
admet-3091	88	24	size	size	NOUN
admet-3091	88	25	effects	effect	NOUN
admet-3091	88	26	on	on	ADP
admet-3091	88	27	release	release	NOUN
admet-3091	88	28	are	be	AUX
admet-3091	88	29	particularly	particularly	ADV
admet-3091	88	30	pronounced	pronounce	VERB
admet-3091	88	31	.	.	PUNCT
admet-3091	89	1	microfluidic	microfluidic	ADJ
admet-3091	89	2	-	-	PUNCT
admet-3091	89	3	produced	produce	VERB
admet-3091	89	4	nanoparticles	nanoparticle	NOUN
admet-3091	89	5	(	(	PUNCT
admet-3091	89	6	102	102	NUM
admet-3091	89	7	nm	nm	NOUN
admet-3091	89	8	)	)	PUNCT
admet-3091	89	9	showed	show	VERB
admet-3091	89	10	increased	increase	VERB
admet-3091	89	11	burst	burst	ADJ
admet-3091	89	12	release	release	NOUN
admet-3091	89	13	(	(	PUNCT
admet-3091	89	14	70	70	NUM
admet-3091	89	15	%	%	NOUN
admet-3091	89	16	after	after	ADP
admet-3091	89	17	1	1	NUM
admet-3091	89	18	hour	hour	NOUN
admet-3091	89	19	)	)	PUNCT
admet-3091	89	20	compared	compare	VERB
admet-3091	89	21	to	to	ADP
admet-3091	89	22	nanoprecipitationproduced	nanoprecipitationproduced	ADJ
admet-3091	89	23	particles	particle	NOUN
admet-3091	89	24	(	(	PUNCT
admet-3091	89	25	189	189	NUM
admet-3091	89	26	nm	nm	NOUN
admet-3091	89	27	)	)	PUNCT
admet-3091	89	28	with	with	ADP
admet-3091	89	29	50	50	NUM
admet-3091	89	30	%	%	NOUN
admet-3091	89	31	burst	burst	NOUN
admet-3091	89	32	release	release	NOUN
admet-3091	89	33	within	within	ADP
admet-3091	89	34	1	1	NUM
admet-3091	89	35	hour	hour	NOUN
admet-3091	89	36	and	and	CCONJ
admet-3091	89	37	nearly	nearly	ADV
admet-3091	89	38	complete	complete	ADJ
admet-3091	89	39	release	release	NOUN
admet-3091	89	40	for	for	ADP
admet-3091	89	41	both	both	DET
admet-3091	89	42	formulations	formulation	NOUN
admet-3091	89	43	at	at	ADP
admet-3091	89	44	24	24	NUM
admet-3091	89	45	hours	hour	NOUN
admet-3091	89	46	[	[	X
admet-3091	89	47	21	21	NUM
admet-3091	89	48	]	]	PUNCT
admet-3091	89	49	.	.	PUNCT
admet-3091	90	1	a	a	DET
admet-3091	90	2	study	study	NOUN
admet-3091	90	3	by	by	ADP
admet-3091	90	4	han	han	PROPN
admet-3091	90	5	et	et	PROPN
admet-3091	90	6	al	al	PROPN
admet-3091	90	7	.	.	PUNCT
admet-3091	91	1	[	[	X
admet-3091	91	2	22	22	NUM
admet-3091	91	3	]	]	PUNCT
admet-3091	91	4	demonstrated	demonstrate	VERB
admet-3091	91	5	sustained	sustained	ADJ
admet-3091	91	6	release	release	NOUN
admet-3091	91	7	of	of	ADP
admet-3091	91	8	a	a	DET
admet-3091	91	9	c5ar1	c5ar1	NOUN
admet-3091	91	10	-	-	PUNCT
admet-3091	91	11	targeted	target	VERB
admet-3091	91	12	hexapeptide	hexapeptide	NOUN
admet-3091	91	13	(	(	PUNCT
admet-3091	91	14	hc-[opdchawr	hc-[opdchawr	PROPN
admet-3091	91	15	]	]	X
admet-3091	91	16	)	)	PUNCT
admet-3091	91	17	from	from	ADP
admet-3091	91	18	lipid	lipid	ADJ
admet-3091	91	19	shell	shell	NOUN
admet-3091	91	20	-	-	PUNCT
admet-3091	91	21	plga	plga	NOUN
admet-3091	91	22	core	core	NOUN
admet-3091	91	23	nanoparticles	nanoparticle	NOUN
admet-3091	91	24	.	.	PUNCT
admet-3091	92	1	nanoparticles	nanoparticle	NOUN
admet-3091	92	2	fabricated	fabricate	VERB
admet-3091	92	3	using	use	VERB
admet-3091	92	4	acetonitrile	acetonitrile	NOUN
admet-3091	92	5	(	(	PUNCT
admet-3091	92	6	acn	acn	PROPN
admet-3091	92	7	)	)	PUNCT
admet-3091	92	8	showed	show	VERB
admet-3091	92	9	rapid	rapid	ADJ
admet-3091	92	10	release	release	NOUN
admet-3091	92	11	(	(	PUNCT
admet-3091	92	12	90.0	90.0	NUM
admet-3091	92	13	±	±	NUM
admet-3091	92	14	9.0	9.0	NUM
admet-3091	92	15	%	%	NOUN
admet-3091	92	16	at	at	ADP
admet-3091	92	17	72	72	NUM
admet-3091	92	18	h	h	NOUN
admet-3091	92	19	)	)	PUNCT
admet-3091	92	20	,	,	PUNCT
admet-3091	92	21	attributed	attribute	VERB
admet-3091	92	22	to	to	ADP
admet-3091	92	23	a	a	DET
admet-3091	92	24	smaller	small	ADJ
admet-3091	92	25	particle	particle	NOUN
admet-3091	92	26	size	size	NOUN
admet-3091	92	27	(	(	PUNCT
admet-3091	92	28	150	150	NOUN
admet-3091	92	29	nm	nm	NOUN
admet-3091	92	30	)	)	PUNCT
admet-3091	92	31	and	and	CCONJ
admet-3091	92	32	lack	lack	NOUN
admet-3091	92	33	of	of	ADP
admet-3091	92	34	lipid	lipid	ADJ
admet-3091	92	35	shell	shell	NOUN
admet-3091	92	36	.	.	PUNCT
admet-3091	93	1	the	the	DET
admet-3091	93	2	microfluidic	microfluidic	ADJ
admet-3091	93	3	method	method	NOUN
admet-3091	93	4	enabled	enable	VERB
admet-3091	93	5	precise	precise	ADJ
admet-3091	93	6	control	control	NOUN
admet-3091	93	7	of	of	ADP
admet-3091	93	8	particle	particle	NOUN
admet-3091	93	9	size	size	NOUN
admet-3091	93	10	(	(	PUNCT
admet-3091	93	11	30	30	NUM
admet-3091	93	12	-	-	SYM
admet-3091	93	13	600	600	NUM
admet-3091	93	14	nm	nm	NOUN
admet-3091	93	15	)	)	PUNCT
admet-3091	93	16	and	and	CCONJ
admet-3091	93	17	pdi	pdi	PROPN
admet-3091	93	18	(	(	PUNCT
admet-3091	93	19	<	<	X
admet-3091	93	20	0.3	0.3	NUM
admet-3091	93	21	)	)	PUNCT
admet-3091	93	22	,	,	PUNCT
admet-3091	93	23	which	which	PRON
admet-3091	93	24	are	be	AUX
admet-3091	93	25	critical	critical	ADJ
admet-3091	93	26	for	for	ADP
admet-3091	93	27	tuning	tune	VERB
admet-3091	93	28	release	release	NOUN
admet-3091	93	29	kinetics	kinetic	NOUN
admet-3091	93	30	.	.	PUNCT
admet-3091	94	1	larger	large	ADJ
admet-3091	94	2	nanoparticles	nanoparticle	NOUN
admet-3091	94	3	(	(	PUNCT
admet-3091	94	4	400	400	NUM
admet-3091	94	5	nm	nm	NOUN
admet-3091	94	6	)	)	PUNCT
admet-3091	94	7	produced	produce	VERB
admet-3091	94	8	with	with	ADP
admet-3091	94	9	dcm	dcm	PROPN
admet-3091	94	10	showed	show	VERB
admet-3091	94	11	slower	slow	ADJ
admet-3091	94	12	release	release	NOUN
admet-3091	94	13	due	due	ADP
admet-3091	94	14	to	to	ADP
admet-3091	94	15	a	a	DET
admet-3091	94	16	lower	low	ADJ
admet-3091	94	17	surface	surface	NOUN
admet-3091	94	18	area	area	NOUN
admet-3091	94	19	-	-	PUNCT
admet-3091	94	20	to	to	ADP
admet-3091	94	21	-	-	PUNCT
admet-3091	94	22	volume	volume	NOUN
admet-3091	94	23	ratio	ratio	NOUN
admet-3091	94	24	.	.	PUNCT
admet-3091	95	1	smaller	small	ADJ
admet-3091	95	2	nanoparticles	nanoparticle	NOUN
admet-3091	95	3	(	(	PUNCT
admet-3091	95	4	<	<	X
admet-3091	95	5	150	150	NUM
admet-3091	95	6	nm	nm	NOUN
admet-3091	95	7	)	)	PUNCT
admet-3091	95	8	from	from	ADP
admet-3091	95	9	acn	acn	PROPN
admet-3091	95	10	or	or	CCONJ
admet-3091	95	11	acetone	acetone	NOUN
admet-3091	95	12	led	lead	VERB
admet-3091	95	13	to	to	ADP
admet-3091	95	14	faster	fast	ADJ
admet-3091	95	15	diffusion	diffusion	NOUN
admet-3091	95	16	-	-	PUNCT
admet-3091	95	17	driven	drive	VERB
admet-3091	95	18	release	release	NOUN
admet-3091	95	19	.	.	PUNCT
admet-3091	96	1	solvent	solvent	ADJ
admet-3091	96	2	miscibility	miscibility	NOUN
admet-3091	96	3	in	in	ADP
admet-3091	96	4	water	water	NOUN
admet-3091	96	5	(	(	PUNCT
admet-3091	96	6	e.g.	e.g.	ADV
admet-3091	96	7	acn	acn	PROPN
admet-3091	96	8	’s	’s	PART
admet-3091	96	9	high	high	ADJ
admet-3091	96	10	miscibility	miscibility	NOUN
admet-3091	96	11	)	)	PUNCT
admet-3091	96	12	increased	increase	VERB
admet-3091	96	13	nucleation	nucleation	NOUN
admet-3091	96	14	rate	rate	NOUN
admet-3091	96	15	,	,	PUNCT
admet-3091	96	16	favouring	favour	VERB
admet-3091	96	17	smaller	small	ADJ
admet-3091	96	18	particles	particle	NOUN
admet-3091	96	19	and	and	CCONJ
admet-3091	96	20	faster	fast	ADJ
admet-3091	96	21	release	release	NOUN
admet-3091	96	22	.	.	PUNCT
admet-3091	97	1	the	the	DET
admet-3091	97	2	prolonged	prolong	VERB
admet-3091	97	3	-	-	PUNCT
admet-3091	97	4	release	release	NOUN
admet-3091	97	5	profile	profile	NOUN
admet-3091	97	6	correlated	correlate	VERB
admet-3091	97	7	with	with	ADP
admet-3091	97	8	improved	improve	VERB
admet-3091	97	9	in	in	ADP
admet-3091	97	10	vivo	vivo	ADJ
admet-3091	97	11	performance	performance	NOUN
admet-3091	97	12	in	in	ADP
admet-3091	97	13	preclinical	preclinical	ADJ
admet-3091	97	14	models	model	NOUN
admet-3091	97	15	of	of	ADP
admet-3091	97	16	lung	lung	NOUN
admet-3091	97	17	disease	disease	NOUN
admet-3091	97	18	.	.	PUNCT
admet-3091	98	1	end	end	NOUN
admet-3091	98	2	-	-	PUNCT
admet-3091	98	3	group	group	NOUN
admet-3091	98	4	and	and	CCONJ
admet-3091	98	5	electrostatic	electrostatic	ADJ
admet-3091	98	6	interactions	interaction	NOUN
admet-3091	98	7	electrostatic	electrostatic	ADJ
admet-3091	98	8	interactions	interaction	NOUN
admet-3091	98	9	between	between	ADP
admet-3091	98	10	charged	charge	VERB
admet-3091	98	11	peptides	peptide	NOUN
admet-3091	98	12	and	and	CCONJ
admet-3091	98	13	plga	plga	VERB
admet-3091	98	14	degradation	degradation	NOUN
admet-3091	98	15	products	product	NOUN
admet-3091	98	16	critically	critically	ADV
admet-3091	98	17	influence	influence	NOUN
admet-3091	98	18	release	release	NOUN
admet-3091	98	19	kinetics	kinetic	NOUN
admet-3091	99	1	[	[	X
admet-3091	99	2	13,23	13,23	NUM
admet-3091	99	3	]	]	PUNCT
admet-3091	99	4	.	.	PUNCT
admet-3091	100	1	as	as	SCONJ
admet-3091	100	2	plga	plga	NOUN
admet-3091	100	3	degrades	degrade	VERB
admet-3091	100	4	,	,	PUNCT
admet-3091	100	5	it	it	PRON
admet-3091	100	6	generates	generate	VERB
admet-3091	100	7	negatively	negatively	ADV
admet-3091	100	8	charged	charge	VERB
admet-3091	100	9	carboxylic	carboxylic	ADJ
admet-3091	100	10	acid	acid	NOUN
admet-3091	100	11	groups	group	NOUN
admet-3091	100	12	that	that	PRON
admet-3091	100	13	strongly	strongly	ADV
admet-3091	100	14	bind	bind	VERB
admet-3091	100	15	positively	positively	ADV
admet-3091	100	16	charged	charge	VERB
admet-3091	100	17	peptides	peptide	NOUN
admet-3091	100	18	,	,	PUNCT
admet-3091	100	19	significantly	significantly	ADV
admet-3091	100	20	impeding	impede	VERB
admet-3091	100	21	their	their	PRON
admet-3091	100	22	diffusion	diffusion	NOUN
admet-3091	100	23	.	.	PUNCT
admet-3091	101	1	balmert	balmert	PROPN
admet-3091	101	2	et	et	PROPN
admet-3091	101	3	al	al	PROPN
admet-3091	101	4	.	.	PUNCT
admet-3091	102	1	[	[	X
admet-3091	102	2	13	13	NUM
admet-3091	102	3	]	]	PUNCT
admet-3091	102	4	showed	show	VERB
admet-3091	102	5	that	that	SCONJ
admet-3091	102	6	peptides	peptide	NOUN
admet-3091	102	7	with	with	ADP
admet-3091	102	8	higher	high	ADJ
admet-3091	102	9	net	net	ADJ
admet-3091	102	10	positive	positive	ADJ
admet-3091	102	11	charge	charge	NOUN
admet-3091	102	12	released	release	VERB
admet-3091	102	13	significantly	significantly	ADV
admet-3091	102	14	slower	slow	ADV
admet-3091	102	15	:	:	PUNCT
admet-3091	102	16	a	a	DET
admet-3091	102	17	peptide	peptide	NOUN
admet-3091	102	18	with	with	ADP
admet-3091	102	19	+3.1	+3.1	ADJ
admet-3091	102	20	charge	charge	NOUN
admet-3091	102	21	per	per	ADP
admet-3091	102	22	kda	kda	NOUN
admet-3091	102	23	exhibited	exhibit	VERB
admet-3091	102	24	<	<	X
admet-3091	102	25	20	20	NUM
admet-3091	102	26	%	%	NOUN
admet-3091	102	27	cumulative	cumulative	ADJ
admet-3091	102	28	release	release	NOUN
admet-3091	102	29	over	over	ADP
admet-3091	102	30	58	58	NUM
admet-3091	102	31	days	day	NOUN
admet-3091	102	32	,	,	PUNCT
admet-3091	102	33	compared	compare	VERB
admet-3091	102	34	to	to	ADP
admet-3091	102	35	near	near	ADV
admet-3091	102	36	-	-	PUNCT
admet-3091	102	37	complete	complete	ADJ
admet-3091	102	38	release	release	NOUN
admet-3091	102	39	of	of	ADP
admet-3091	102	40	a	a	DET
admet-3091	102	41	neutral	neutral	ADJ
admet-3091	102	42	peptide	peptide	NOUN
admet-3091	102	43	within	within	ADP
admet-3091	102	44	13	13	NUM
admet-3091	102	45	to	to	PART
admet-3091	102	46	58	58	NUM
admet-3091	102	47	days	day	NOUN
admet-3091	102	48	,	,	PUNCT
admet-3091	102	49	depending	depend	VERB
admet-3091	102	50	on	on	ADP
admet-3091	102	51	plga	plga	NOUN
admet-3091	102	52	type	type	NOUN
admet-3091	102	53	.	.	PUNCT
admet-3091	103	1	maximum	maximum	ADJ
admet-3091	103	2	daily	daily	ADJ
admet-3091	103	3	release	release	NOUN
admet-3091	103	4	rates	rate	NOUN
admet-3091	103	5	also	also	ADV
admet-3091	103	6	declined	decline	VERB
admet-3091	103	7	with	with	ADP
admet-3091	103	8	increasing	increase	VERB
admet-3091	103	9	charge	charge	NOUN
admet-3091	103	10	,	,	PUNCT
admet-3091	103	11	from	from	ADP
admet-3091	103	12	6.9	6.9	PROPN
admet-3091	103	13	%	%	NOUN
admet-3091	103	14	day-1	day-1	X
admet-3091	103	15	for	for	ADP
admet-3091	103	16	neutral	neutral	ADJ
admet-3091	103	17	peptides	peptide	NOUN
admet-3091	103	18	to	to	ADP
admet-3091	103	19	<	<	X
admet-3091	103	20	1	1	NUM
admet-3091	103	21	%	%	NOUN
admet-3091	103	22	per	per	ADP
admet-3091	103	23	day	day	NOUN
admet-3091	103	24	for	for	ADP
admet-3091	103	25	highly	highly	ADV
admet-3091	103	26	cationic	cationic	ADJ
admet-3091	103	27	peptides	peptide	NOUN
admet-3091	103	28	.	.	PUNCT
admet-3091	104	1	this	this	DET
admet-3091	104	2	charge	charge	NOUN
admet-3091	104	3	effect	effect	NOUN
admet-3091	104	4	was	be	AUX
admet-3091	104	5	consistent	consistent	ADJ
admet-3091	104	6	across	across	ADP
admet-3091	104	7	plga	plga	NOUN
admet-3091	104	8	types	type	NOUN
admet-3091	104	9	,	,	PUNCT
admet-3091	104	10	including	include	VERB
admet-3091	104	11	7	7	NUM
admet-3091	104	12	,	,	PUNCT
admet-3091	104	13	15	15	NUM
admet-3091	104	14	and	and	CCONJ
admet-3091	104	15	43	43	NUM
admet-3091	104	16	kda	kda	NOUN
admet-3091	104	17	.	.	PUNCT
admet-3091	105	1	in	in	ADP
admet-3091	105	2	leuprolide	leuprolide	NOUN
admet-3091	105	3	delivery	delivery	NOUN
admet-3091	105	4	systems	system	NOUN
admet-3091	105	5	,	,	PUNCT
admet-3091	105	6	plgas	plgas	NOUN
admet-3091	105	7	with	with	ADP
admet-3091	105	8	free	free	ADJ
admet-3091	105	9	carboxylic	carboxylic	ADJ
admet-3091	105	10	acid	acid	NOUN
admet-3091	105	11	end	end	NOUN
admet-3091	105	12	groups	group	NOUN
admet-3091	105	13	exhibited	exhibit	VERB
admet-3091	105	14	lower	low	ADJ
admet-3091	105	15	initial	initial	ADJ
admet-3091	105	16	release	release	NOUN
admet-3091	105	17	(	(	PUNCT
admet-3091	105	18	7.2	7.2	NUM
admet-3091	105	19	%	%	NOUN
admet-3091	105	20	)	)	PUNCT
admet-3091	105	21	compared	compare	VERB
admet-3091	105	22	to	to	ADP
admet-3091	105	23	ester	ester	NOUN
admet-3091	105	24	-	-	PUNCT
admet-3091	105	25	terminated	terminate	VERB
admet-3091	105	26	variants	variant	NOUN
admet-3091	105	27	(	(	PUNCT
admet-3091	105	28	32.0	32.0	NUM
admet-3091	105	29	%	%	NOUN
admet-3091	105	30	)	)	PUNCT
admet-3091	105	31	,	,	PUNCT
admet-3091	105	32	attributed	attribute	VERB
admet-3091	105	33	to	to	ADP
admet-3091	105	34	electrostatic	electrostatic	ADJ
admet-3091	105	35	interactions	interaction	NOUN
admet-3091	105	36	between	between	ADP
admet-3091	105	37	leuprolide	leuprolide	NOUN
admet-3091	105	38	's	's	PART
admet-3091	105	39	basic	basic	ADJ
admet-3091	105	40	groups	group	NOUN
admet-3091	105	41	and	and	CCONJ
admet-3091	105	42	the	the	DET
admet-3091	105	43	acidic	acidic	ADJ
admet-3091	105	44	polymer	polymer	NOUN
admet-3091	105	45	terminus	terminus	NOUN
admet-3091	106	1	[	[	X
admet-3091	106	2	8	8	NUM
admet-3091	106	3	]	]	PUNCT
admet-3091	106	4	.	.	PUNCT
admet-3091	107	1	the	the	DET
admet-3091	107	2	acidic	acidic	ADJ
admet-3091	107	3	microenvironment	microenvironment	NOUN
admet-3091	107	4	created	create	VERB
admet-3091	107	5	during	during	ADP
admet-3091	107	6	plga	plga	NOUN
admet-3091	107	7	degradation	degradation	NOUN
admet-3091	107	8	(	(	PUNCT
admet-3091	107	9	ph	ph	NOUN
admet-3091	107	10	as	as	ADV
admet-3091	107	11	low	low	ADJ
admet-3091	107	12	as	as	ADP
admet-3091	107	13	2.2	2.2	NUM
admet-3091	107	14	)	)	PUNCT
admet-3091	107	15	increases	increase	VERB
admet-3091	107	16	peptide	peptide	ADJ
admet-3091	107	17	protonation	protonation	NOUN
admet-3091	107	18	and	and	CCONJ
admet-3091	107	19	binding	bind	VERB
admet-3091	107	20	[	[	X
admet-3091	107	21	12,24	12,24	NUM
admet-3091	107	22	]	]	PUNCT
admet-3091	107	23	.	.	PUNCT
admet-3091	108	1	this	this	DET
admet-3091	108	2	effect	effect	NOUN
admet-3091	108	3	is	be	AUX
admet-3091	108	4	particularly	particularly	ADV
admet-3091	108	5	problematic	problematic	ADJ
admet-3091	108	6	for	for	ADP
admet-3091	108	7	cationic	cationic	ADJ
admet-3091	108	8	peptides	peptide	NOUN
admet-3091	108	9	,	,	PUNCT
admet-3091	108	10	where	where	SCONJ
admet-3091	108	11	electrostatic	electrostatic	ADJ
admet-3091	108	12	interactions	interaction	NOUN
admet-3091	108	13	can	can	AUX
admet-3091	108	14	delay	delay	VERB
admet-3091	108	15	release	release	NOUN
admet-3091	108	16	by	by	ADP
admet-3091	108	17	15	15	NUM
admet-3091	108	18	to	to	PART
admet-3091	108	19	20	20	NUM
admet-3091	108	20	days	day	NOUN
admet-3091	108	21	[	[	X
admet-3091	108	22	25	25	NUM
admet-3091	108	23	]	]	PUNCT
admet-3091	108	24	.	.	PUNCT
admet-3091	109	1	strategies	strategy	NOUN
admet-3091	109	2	to	to	PART
admet-3091	109	3	mitigate	mitigate	VERB
admet-3091	109	4	these	these	DET
admet-3091	109	5	interactions	interaction	NOUN
admet-3091	109	6	include	include	VERB
admet-3091	109	7	co	co	NOUN
admet-3091	109	8	-	-	NOUN
admet-3091	109	9	encapsulation	encapsulation	NOUN
admet-3091	109	10	of	of	ADP
admet-3091	109	11	basic	basic	ADJ
admet-3091	109	12	additives	additive	NOUN
admet-3091	109	13	,	,	PUNCT
admet-3091	109	14	such	such	ADJ
admet-3091	109	15	as	as	ADP
admet-3091	109	16	l	l	NOUN
admet-3091	109	17	-	-	NOUN
admet-3091	109	18	histidine	histidine	NOUN
admet-3091	109	19	,	,	PUNCT
admet-3091	109	20	which	which	PRON
admet-3091	109	21	acts	act	VERB
admet-3091	109	22	as	as	ADP
admet-3091	109	23	a	a	DET
admet-3091	109	24	proton	proton	NOUN
admet-3091	109	25	scavenger	scavenger	NOUN
admet-3091	109	26	and	and	CCONJ
admet-3091	109	27	preserves	preserve	VERB
admet-3091	109	28	peptide	peptide	ADJ
admet-3091	109	29	activity	activity	NOUN
admet-3091	109	30	[	[	X
admet-3091	109	31	23	23	NUM
admet-3091	109	32	]	]	PUNCT
admet-3091	109	33	.	.	PUNCT
admet-3091	110	1	peptide	peptide	NOUN
admet-3091	110	2	properties	property	NOUN
admet-3091	110	3	peptide	peptide	VERB
admet-3091	110	4	physicochemical	physicochemical	ADJ
admet-3091	110	5	properties	property	NOUN
admet-3091	110	6	,	,	PUNCT
admet-3091	110	7	including	include	VERB
admet-3091	110	8	molecular	molecular	ADJ
admet-3091	110	9	weight	weight	NOUN
admet-3091	110	10	,	,	PUNCT
admet-3091	110	11	charge	charge	NOUN
admet-3091	110	12	,	,	PUNCT
admet-3091	110	13	and	and	CCONJ
admet-3091	110	14	hydrophobicity	hydrophobicity	NOUN
admet-3091	110	15	,	,	PUNCT
admet-3091	110	16	significantly	significantly	ADV
admet-3091	110	17	influence	influence	VERB
admet-3091	110	18	release	release	NOUN
admet-3091	110	19	kinetics	kinetic	NOUN
admet-3091	110	20	.	.	PUNCT
admet-3091	111	1	hydrophilic	hydrophilic	ADJ
admet-3091	111	2	peptides	peptide	NOUN
admet-3091	111	3	typically	typically	ADV
admet-3091	111	4	show	show	VERB
admet-3091	111	5	faster	fast	ADJ
admet-3091	111	6	release	release	NOUN
admet-3091	111	7	than	than	ADP
admet-3091	111	8	hydrophobic	hydrophobic	NOUN
admet-3091	111	9	ones	one	NOUN
admet-3091	111	10	due	due	ADJ
admet-3091	111	11	to	to	ADP
admet-3091	111	12	weaker	weak	ADJ
admet-3091	111	13	interactions	interaction	NOUN
admet-3091	111	14	with	with	ADP
admet-3091	111	15	the	the	DET
admet-3091	111	16	plga	plga	NOUN
admet-3091	111	17	matrix	matrix	NOUN
admet-3091	111	18	[	[	X
admet-3091	111	19	14,26	14,26	NOUN
admet-3091	111	20	]	]	PUNCT
admet-3091	111	21	.	.	PUNCT
admet-3091	112	1	in	in	ADP
admet-3091	112	2	one	one	NUM
admet-3091	112	3	study	study	NOUN
admet-3091	112	4	,	,	PUNCT
admet-3091	112	5	hydrophilic	hydrophilic	ADJ
admet-3091	112	6	oxytocin	oxytocin	PROPN
admet-3091	112	7	exhibited	exhibit	VERB
admet-3091	112	8	50	50	INTJ
admet-3091	112	9	%	%	NOUN
admet-3091	112	10	burst	burst	NOUN
admet-3091	112	11	release	release	NOUN
admet-3091	112	12	within	within	ADP
admet-3091	112	13	1	1	NUM
admet-3091	112	14	hour	hour	NOUN
admet-3091	112	15	and	and	CCONJ
admet-3091	112	16	near	near	ADV
admet-3091	112	17	-	-	PUNCT
admet-3091	112	18	complete	complete	ADJ
admet-3091	112	19	release	release	NOUN
admet-3091	112	20	within	within	ADP
admet-3091	112	21	35	35	NUM
admet-3091	112	22	hours	hour	NOUN
admet-3091	112	23	,	,	PUNCT
admet-3091	112	24	whereas	whereas	SCONJ
admet-3091	112	25	hydrophobic	hydrophobic	NOUN
admet-3091	112	26	lhrh	lhrh	NOUN
admet-3091	112	27	demonstrated	demonstrate	VERB
admet-3091	112	28	sustained	sustained	ADJ
admet-3091	112	29	release	release	NOUN
admet-3091	112	30	over	over	ADP
admet-3091	112	31	weeks	week	NOUN
admet-3091	112	32	due	due	ADP
admet-3091	112	33	to	to	ADP
admet-3091	112	34	hydrophobic	hydrophobic	VERB
admet-3091	112	35	partitioning	partitioning	NOUN
admet-3091	113	1	[	[	X
admet-3091	113	2	14	14	NUM
admet-3091	113	3	]	]	PUNCT
admet-3091	113	4	.	.	PUNCT
admet-3091	114	1	in	in	ADP
admet-3091	114	2	another	another	DET
admet-3091	114	3	study	study	NOUN
admet-3091	114	4	,	,	PUNCT
admet-3091	114	5	the	the	DET
admet-3091	114	6	hydrophobic	hydrophobic	ADJ
admet-3091	114	7	20	20	NUM
admet-3091	114	8	-	-	PUNCT
admet-3091	114	9	mer	mer	NOUN
admet-3091	114	10	anti	anti	ADJ
admet-3091	114	11	-	-	ADJ
admet-3091	114	12	angiogenic	angiogenic	ADJ
admet-3091	114	13	peptide	peptide	NOUN
admet-3091	114	14	showed	show	VERB
admet-3091	114	15	prolonged	prolonged	ADJ
admet-3091	114	16	release	release	NOUN
admet-3091	114	17	over	over	ADP
admet-3091	114	18	6	6	NUM
admet-3091	114	19	months	month	NOUN
admet-3091	114	20	in	in	ADP
admet-3091	114	21	85:15	85:15	NUM
admet-3091	114	22	plga	plga	NOUN
admet-3091	114	23	microparticles	microparticle	NOUN
admet-3091	114	24	[	[	X
admet-3091	114	25	16	16	NUM
admet-3091	114	26	]	]	PUNCT
admet-3091	114	27	.	.	PUNCT
admet-3091	115	1	one	one	NUM
admet-3091	115	2	strategy	strategy	NOUN
admet-3091	115	3	to	to	PART
admet-3091	115	4	mitigate	mitigate	VERB
admet-3091	115	5	the	the	DET
admet-3091	115	6	burst	burst	ADJ
admet-3091	115	7	release	release	NOUN
admet-3091	115	8	of	of	ADP
admet-3091	115	9	hydrophilic	hydrophilic	ADJ
admet-3091	115	10	peptides	peptide	NOUN
admet-3091	115	11	is	be	AUX
admet-3091	115	12	to	to	PART
admet-3091	115	13	graft	graft	VERB
admet-3091	115	14	hydrophobic	hydrophobic	NOUN
admet-3091	115	15	moieties	moiety	NOUN
admet-3091	115	16	,	,	PUNCT
admet-3091	115	17	such	such	ADJ
admet-3091	115	18	as	as	ADP
admet-3091	115	19	phenylalanine	phenylalanine	NOUN
admet-3091	115	20	,	,	PUNCT
admet-3091	115	21	onto	onto	ADP
admet-3091	115	22	plga	plga	NOUN
admet-3091	115	23	,	,	PUNCT
admet-3091	115	24	or	or	CCONJ
admet-3091	115	25	to	to	PART
admet-3091	115	26	employ	employ	VERB
admet-3091	115	27	cyclodextrin	cyclodextrin	ADJ
admet-3091	115	28	complexation	complexation	NOUN
admet-3091	115	29	.	.	PUNCT
admet-3091	116	1	these	these	DET
admet-3091	116	2	approaches	approach	NOUN
admet-3091	116	3	enhance	enhance	VERB
admet-3091	116	4	peptide	peptide	ADJ
admet-3091	116	5	stability	stability	NOUN
admet-3091	116	6	within	within	ADP
admet-3091	116	7	the	the	DET
admet-3091	116	8	delivery	delivery	NOUN
admet-3091	116	9	matrix	matrix	NOUN
admet-3091	116	10	and	and	CCONJ
admet-3091	116	11	effectively	effectively	ADV
admet-3091	116	12	reduce	reduce	VERB
admet-3091	116	13	the	the	DET
admet-3091	116	14	initial	initial	ADJ
admet-3091	116	15	burst	burst	ADJ
admet-3091	116	16	release	release	NOUN
admet-3091	117	1	[	[	X
admet-3091	117	2	26	26	NUM
admet-3091	117	3	]	]	PUNCT
admet-3091	117	4	.	.	PUNCT
admet-3091	118	1	peptide	peptide	ADJ
admet-3091	118	2	size	size	NOUN
admet-3091	118	3	also	also	ADV
admet-3091	118	4	affects	affect	VERB
admet-3091	118	5	diffusion	diffusion	NOUN
admet-3091	118	6	rates	rate	NOUN
admet-3091	118	7	,	,	PUNCT
admet-3091	118	8	with	with	ADP
admet-3091	118	9	smaller	small	ADJ
admet-3091	118	10	peptides	peptide	NOUN
admet-3091	118	11	(	(	PUNCT
admet-3091	118	12	<	<	X
admet-3091	118	13	10	10	NUM
admet-3091	118	14	kda	kda	NOUN
admet-3091	118	15	)	)	PUNCT
admet-3091	118	16	diffusing	diffuse	VERB
admet-3091	118	17	faster	fast	ADV
admet-3091	118	18	due	due	ADJ
admet-3091	118	19	to	to	ADP
admet-3091	118	20	reduced	reduce	VERB
admet-3091	118	21	steric	steric	ADJ
admet-3091	118	22	hindrance	hindrance	NOUN
admet-3091	118	23	.	.	PUNCT
admet-3091	119	1	conversely	conversely	ADV
admet-3091	119	2	,	,	PUNCT
admet-3091	119	3	peptides	peptide	NOUN
admet-3091	119	4	exceeding	exceed	VERB
admet-3091	119	5	20	20	NUM
admet-3091	119	6	kda	kda	NOUN
admet-3091	119	7	demonstrate	demonstrate	NOUN
admet-3091	119	8	significantly	significantly	ADV
admet-3091	119	9	slower	slow	ADJ
admet-3091	119	10	release	release	NOUN
admet-3091	119	11	kinetics	kinetic	NOUN
admet-3091	119	12	,	,	PUNCT
admet-3091	119	13	often	often	ADV
admet-3091	119	14	requiring	require	VERB
admet-3091	119	15	polymer	polymer	NOUN
admet-3091	119	16	erosion	erosion	NOUN
admet-3091	119	17	for	for	ADP
admet-3091	119	18	complete	complete	ADJ
admet-3091	119	19	liberation	liberation	NOUN
admet-3091	119	20	[	[	X
admet-3091	119	21	27	27	NUM
admet-3091	119	22	]	]	PUNCT
admet-3091	119	23	.	.	PUNCT
admet-3091	120	1	as	as	SCONJ
admet-3091	120	2	discussed	discuss	VERB
admet-3091	120	3	in	in	ADP
admet-3091	120	4	section	section	NOUN
admet-3091	120	5	2.4	2.4	NUM
admet-3091	120	6	,	,	PUNCT
admet-3091	120	7	higher	high	ADJ
admet-3091	120	8	positive	positive	ADJ
admet-3091	120	9	charges	charge	NOUN
admet-3091	120	10	correlate	correlate	VERB
admet-3091	120	11	with	with	ADP
admet-3091	120	12	slower	slow	ADJ
admet-3091	120	13	release	release	NOUN
admet-3091	120	14	rates	rate	NOUN
admet-3091	120	15	due	due	ADJ
admet-3091	120	16	to	to	ADP
admet-3091	120	17	electrostatic	electrostatic	ADJ
admet-3091	120	18	interactions	interaction	NOUN
admet-3091	120	19	with	with	ADP
admet-3091	120	20	the	the	DET
admet-3091	120	21	plga	plga	NOUN
admet-3091	120	22	matrix	matrix	NOUN
admet-3091	120	23	,	,	PUNCT
admet-3091	120	24	especially	especially	ADV
admet-3091	120	25	in	in	ADP
admet-3091	120	26	the	the	DET
admet-3091	120	27	case	case	NOUN
admet-3091	120	28	of	of	ADP
admet-3091	120	29	carboxylic	carboxylic	ADJ
admet-3091	120	30	acid	acid	NOUN
admet-3091	120	31	-	-	PUNCT
admet-3091	120	32	terminated	terminate	VERB
admet-3091	120	33	plga	plga	NOUN
admet-3091	120	34	.	.	PUNCT
admet-3091	121	1	one	one	NUM
admet-3091	121	2	mitigating	mitigate	VERB
admet-3091	121	3	strategy	strategy	NOUN
admet-3091	121	4	was	be	AUX
admet-3091	121	5	to	to	PART
admet-3091	121	6	convert	convert	VERB
admet-3091	121	7	peptides	peptide	NOUN
admet-3091	121	8	to	to	ADP
admet-3091	121	9	zinc	zinc	NOUN
admet-3091	121	10	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	121	11	m.	m.	PROPN
admet-3091	121	12	eshaghi	eshaghi	PROPN
admet-3091	121	13	et	et	PROPN
admet-3091	121	14	al	al	PROPN
admet-3091	121	15	.	.	PROPN
admet-3091	121	16	admet	admet	PROPN
admet-3091	121	17	&	&	CCONJ
admet-3091	121	18	dmpk	dmpk	PROPN
admet-3091	121	19	00(0	00(0	PROPN
admet-3091	121	20	)	)	PUNCT
admet-3091	121	21	(	(	PUNCT
admet-3091	121	22	2025	2025	NUM
admet-3091	121	23	)	)	PUNCT
admet-3091	121	24	3091	3091	NUM
admet-3091	121	25	6	6	NUM
admet-3091	121	26	complexes	complex	NOUN
admet-3091	121	27	,	,	PUNCT
admet-3091	121	28	thereby	thereby	ADV
admet-3091	121	29	reducing	reduce	VERB
admet-3091	121	30	positive	positive	ADJ
admet-3091	121	31	charge	charge	NOUN
admet-3091	121	32	and	and	CCONJ
admet-3091	121	33	accelerating	accelerate	VERB
admet-3091	121	34	release	release	NOUN
admet-3091	121	35	by	by	ADP
admet-3091	121	36	40	40	NUM
admet-3091	121	37	%	%	NOUN
admet-3091	121	38	[	[	X
admet-3091	121	39	25	25	NUM
admet-3091	121	40	]	]	PUNCT
admet-3091	121	41	.	.	PUNCT
admet-3091	122	1	maintaining	maintain	VERB
admet-3091	122	2	the	the	DET
admet-3091	122	3	secondary	secondary	ADJ
admet-3091	122	4	structure	structure	NOUN
admet-3091	122	5	also	also	ADV
admet-3091	122	6	influences	influence	VERB
admet-3091	122	7	release	release	NOUN
admet-3091	122	8	behaviour	behaviour	NOUN
admet-3091	122	9	.	.	PUNCT
admet-3091	123	1	in	in	ADP
admet-3091	123	2	a	a	DET
admet-3091	123	3	study	study	NOUN
admet-3091	123	4	,	,	PUNCT
admet-3091	123	5	cyclic	cyclic	ADJ
admet-3091	123	6	peptides	peptide	NOUN
admet-3091	123	7	(	(	PUNCT
admet-3091	123	8	e.g.	e.g.	ADV
admet-3091	123	9	ciclosporin	ciclosporin	NOUN
admet-3091	123	10	a	a	NOUN
admet-3091	123	11	)	)	PUNCT
admet-3091	123	12	demonstrated	demonstrate	VERB
admet-3091	123	13	slower	slow	ADJ
admet-3091	123	14	release	release	NOUN
admet-3091	123	15	(	(	PUNCT
admet-3091	123	16	100	100	NUM
admet-3091	123	17	days	day	NOUN
admet-3091	123	18	)	)	PUNCT
admet-3091	123	19	than	than	ADP
admet-3091	123	20	linear	linear	PROPN
admet-3091	123	21	counterparts	counterpart	NOUN
admet-3091	123	22	due	due	ADP
admet-3091	123	23	to	to	ADP
admet-3091	123	24	structural	structural	ADJ
admet-3091	123	25	stability	stability	NOUN
admet-3091	123	26	[	[	X
admet-3091	123	27	28	28	NUM
admet-3091	123	28	]	]	PUNCT
admet-3091	123	29	.	.	PUNCT
admet-3091	124	1	conformationally	conformationally	ADV
admet-3091	124	2	sensitive	sensitive	ADJ
admet-3091	124	3	peptides	peptide	NOUN
admet-3091	124	4	like	like	ADP
admet-3091	124	5	gdnf	gdnf	ADJ
admet-3091	124	6	require	require	NOUN
admet-3091	124	7	fusion	fusion	NOUN
admet-3091	124	8	tags	tag	NOUN
admet-3091	124	9	(	(	PUNCT
admet-3091	124	10	e.g.	e.g.	ADV
admet-3091	124	11	collagen	collagen	NOUN
admet-3091	124	12	-	-	PUNCT
admet-3091	124	13	binding	bind	VERB
admet-3091	124	14	domain	domain	NOUN
admet-3091	124	15	)	)	PUNCT
admet-3091	124	16	to	to	PART
admet-3091	124	17	maintain	maintain	VERB
admet-3091	124	18	bioactivity	bioactivity	NOUN
admet-3091	124	19	during	during	ADP
admet-3091	124	20	sustained	sustained	ADJ
admet-3091	124	21	release	release	NOUN
admet-3091	124	22	,	,	PUNCT
admet-3091	124	23	as	as	SCONJ
admet-3091	124	24	reported	report	VERB
admet-3091	124	25	in	in	ADP
admet-3091	124	26	another	another	DET
admet-3091	124	27	study	study	NOUN
admet-3091	124	28	[	[	X
admet-3091	124	29	29	29	NUM
admet-3091	124	30	]	]	PUNCT
admet-3091	124	31	.	.	PUNCT
admet-3091	125	1	additionally	additionally	ADV
admet-3091	125	2	,	,	PUNCT
admet-3091	125	3	peptide	peptide	ADJ
admet-3091	125	4	degradation	degradation	NOUN
admet-3091	125	5	during	during	ADP
admet-3091	125	6	release	release	NOUN
admet-3091	125	7	remains	remain	VERB
admet-3091	125	8	a	a	DET
admet-3091	125	9	significant	significant	ADJ
admet-3091	125	10	challenge	challenge	NOUN
admet-3091	125	11	.	.	PUNCT
admet-3091	126	1	nucleophilic	nucleophilic	ADJ
admet-3091	126	2	groups	group	NOUN
admet-3091	126	3	,	,	PUNCT
admet-3091	126	4	such	such	ADJ
admet-3091	126	5	as	as	ADP
admet-3091	126	6	n	n	CCONJ
admet-3091	126	7	-	-	PUNCT
admet-3091	126	8	terminal	terminal	ADJ
admet-3091	126	9	amines	amine	NOUN
admet-3091	126	10	and	and	CCONJ
admet-3091	126	11	lysine	lysine	NOUN
admet-3091	126	12	side	side	NOUN
admet-3091	126	13	chains	chain	NOUN
admet-3091	126	14	,	,	PUNCT
admet-3091	126	15	can	can	AUX
admet-3091	126	16	undergo	undergo	VERB
admet-3091	126	17	acylation	acylation	NOUN
admet-3091	126	18	reactions	reaction	NOUN
admet-3091	126	19	with	with	ADP
admet-3091	126	20	plga	plga	NOUN
admet-3091	126	21	ester	ester	NOUN
admet-3091	126	22	linkages	linkage	NOUN
admet-3091	126	23	,	,	PUNCT
admet-3091	126	24	forming	form	VERB
admet-3091	126	25	covalent	covalent	NOUN
admet-3091	126	26	adducts	adduct	NOUN
admet-3091	126	27	that	that	PRON
admet-3091	126	28	hinder	hinder	VERB
admet-3091	126	29	drug	drug	NOUN
admet-3091	126	30	release	release	NOUN
admet-3091	126	31	.	.	PUNCT
admet-3091	127	1	for	for	ADP
admet-3091	127	2	example	example	NOUN
admet-3091	127	3	,	,	PUNCT
admet-3091	127	4	the	the	DET
admet-3091	127	5	acylation	acylation	NOUN
admet-3091	127	6	of	of	ADP
admet-3091	127	7	octreotide	octreotide	NOUN
admet-3091	127	8	in	in	ADP
admet-3091	127	9	the	the	DET
admet-3091	127	10	commercial	commercial	ADJ
admet-3091	127	11	formulation	formulation	NOUN
admet-3091	127	12	sandostatin	sandostatin	ADJ
admet-3091	127	13	lar	lar	ADJ
admet-3091	127	14	®	®	NOUN
admet-3091	127	15	has	have	AUX
admet-3091	127	16	been	be	AUX
admet-3091	127	17	shown	show	VERB
admet-3091	127	18	to	to	PART
admet-3091	127	19	influence	influence	VERB
admet-3091	127	20	its	its	PRON
admet-3091	127	21	release	release	NOUN
admet-3091	127	22	profile	profile	NOUN
admet-3091	127	23	[	[	X
admet-3091	127	24	30	30	NUM
admet-3091	127	25	]	]	PUNCT
admet-3091	127	26	.	.	PUNCT
admet-3091	128	1	plga	plga	NOUN
admet-3091	128	2	degradation	degradation	NOUN
admet-3091	128	3	creates	create	VERB
admet-3091	128	4	acidic	acidic	ADJ
admet-3091	128	5	microenvironments	microenvironment	NOUN
admet-3091	128	6	,	,	PUNCT
admet-3091	128	7	risking	risk	VERB
admet-3091	128	8	peptide	peptide	ADJ
admet-3091	128	9	denaturation	denaturation	NOUN
admet-3091	128	10	.	.	PUNCT
admet-3091	129	1	as	as	SCONJ
admet-3091	129	2	mentioned	mention	VERB
admet-3091	129	3	in	in	ADP
admet-3091	129	4	section	section	NOUN
admet-3091	129	5	2.4	2.4	NUM
admet-3091	129	6	,	,	PUNCT
admet-3091	129	7	co	co	NOUN
admet-3091	129	8	-	-	NOUN
admet-3091	129	9	encapsulation	encapsulation	NOUN
admet-3091	129	10	of	of	ADP
admet-3091	129	11	l	l	NOUN
admet-3091	129	12	-	-	NOUN
admet-3091	129	13	histidine	histidine	ADJ
admet-3091	129	14	(	(	PUNCT
admet-3091	129	15	≥25	≥25	NOUN
admet-3091	129	16	wt.%	wt.%	NOUN
admet-3091	129	17	)	)	PUNCT
admet-3091	129	18	has	have	AUX
admet-3091	129	19	been	be	AUX
admet-3091	129	20	reported	report	VERB
admet-3091	129	21	to	to	PART
admet-3091	129	22	preserve	preserve	VERB
admet-3091	129	23	functionality	functionality	NOUN
admet-3091	129	24	by	by	ADP
admet-3091	129	25	scavenging	scavenge	VERB
admet-3091	129	26	protons	proton	NOUN
admet-3091	129	27	[	[	X
admet-3091	129	28	23,25	23,25	NOUN
admet-3091	129	29	]	]	X
admet-3091	129	30	.	.	PUNCT
admet-3091	130	1	peptide	peptide	NOUN
admet-3091	130	2	aggregation	aggregation	NOUN
admet-3091	130	3	,	,	PUNCT
admet-3091	130	4	particularly	particularly	ADV
admet-3091	130	5	via	via	ADP
admet-3091	130	6	β	β	ADJ
admet-3091	130	7	-	-	ADJ
admet-3091	130	8	sheet	sheet	NOUN
admet-3091	130	9	formation	formation	NOUN
admet-3091	130	10	,	,	PUNCT
admet-3091	130	11	poses	pose	VERB
admet-3091	130	12	another	another	DET
admet-3091	130	13	challenge	challenge	NOUN
admet-3091	130	14	by	by	ADP
admet-3091	130	15	reducing	reduce	VERB
admet-3091	130	16	bioavailability	bioavailability	NOUN
admet-3091	130	17	.	.	PUNCT
admet-3091	131	1	the	the	DET
admet-3091	131	2	use	use	NOUN
admet-3091	131	3	of	of	ADP
admet-3091	131	4	lyoprotectants	lyoprotectant	NOUN
admet-3091	131	5	such	such	ADJ
admet-3091	131	6	as	as	ADP
admet-3091	131	7	trehalose	trehalose	PROPN
admet-3091	131	8	has	have	AUX
admet-3091	131	9	been	be	AUX
admet-3091	131	10	shown	show	VERB
admet-3091	131	11	to	to	PART
admet-3091	131	12	prevent	prevent	VERB
admet-3091	131	13	aggregation	aggregation	NOUN
admet-3091	131	14	during	during	ADP
admet-3091	131	15	storage	storage	NOUN
admet-3091	131	16	[	[	X
admet-3091	131	17	27	27	NUM
admet-3091	131	18	]	]	SYM
admet-3091	131	19	.	.	PUNCT
admet-3091	132	1	drug	drug	NOUN
admet-3091	132	2	loading	loading	NOUN
admet-3091	132	3	drug	drug	NOUN
admet-3091	132	4	loading	loading	NOUN
admet-3091	132	5	,	,	PUNCT
admet-3091	132	6	the	the	DET
admet-3091	132	7	mass	mass	ADJ
admet-3091	132	8	ratio	ratio	NOUN
admet-3091	132	9	of	of	ADP
admet-3091	132	10	peptide	peptide	NOUN
admet-3091	132	11	to	to	ADP
admet-3091	132	12	polymer	polymer	NOUN
admet-3091	132	13	,	,	PUNCT
admet-3091	132	14	fundamentally	fundamentally	ADV
admet-3091	132	15	influences	influence	VERB
admet-3091	132	16	release	release	NOUN
admet-3091	132	17	profiles	profile	NOUN
admet-3091	132	18	by	by	ADP
admet-3091	132	19	modulating	modulate	VERB
admet-3091	132	20	matrix	matrix	NOUN
admet-3091	132	21	porosity	porosity	NOUN
admet-3091	132	22	and	and	CCONJ
admet-3091	132	23	diffusion	diffusion	NOUN
admet-3091	132	24	pathways	pathway	NOUN
admet-3091	132	25	.	.	PUNCT
admet-3091	133	1	higher	high	ADJ
admet-3091	133	2	loading	loading	NOUN
admet-3091	133	3	usually	usually	ADV
admet-3091	133	4	increases	increase	VERB
admet-3091	133	5	burst	burst	ADJ
admet-3091	133	6	release	release	NOUN
admet-3091	133	7	due	due	ADP
admet-3091	133	8	to	to	ADP
admet-3091	133	9	elevated	elevated	ADJ
admet-3091	133	10	concentration	concentration	NOUN
admet-3091	133	11	gradients	gradient	NOUN
admet-3091	133	12	and	and	CCONJ
admet-3091	133	13	greater	great	ADJ
admet-3091	133	14	surface	surface	NOUN
admet-3091	133	15	-	-	PUNCT
admet-3091	133	16	associated	associate	VERB
admet-3091	133	17	peptide	peptide	NOUN
admet-3091	133	18	but	but	CCONJ
admet-3091	133	19	can	can	AUX
admet-3091	133	20	also	also	ADV
admet-3091	133	21	accelerate	accelerate	VERB
admet-3091	133	22	sustained	sustained	ADJ
admet-3091	133	23	release	release	NOUN
admet-3091	133	24	by	by	ADP
admet-3091	133	25	creating	create	VERB
admet-3091	133	26	interconnected	interconnected	ADJ
admet-3091	133	27	pores	pore	NOUN
admet-3091	133	28	[	[	X
admet-3091	133	29	31,32	31,32	NUM
admet-3091	133	30	]	]	X
admet-3091	133	31	.	.	PUNCT
admet-3091	134	1	tp508	tp508	NOUN
admet-3091	134	2	-	-	PUNCT
admet-3091	134	3	loaded	load	VERB
admet-3091	134	4	plga	plga	NOUN
admet-3091	134	5	/	/	SYM
admet-3091	134	6	peg	peg	NOUN
admet-3091	134	7	microparticles	microparticle	NOUN
admet-3091	134	8	exhibited	exhibit	VERB
admet-3091	134	9	0.23	0.23	NUM
admet-3091	134	10	to	to	ADP
admet-3091	134	11	0.29	0.29	NUM
admet-3091	134	12	mg	mg	PROPN
admet-3091	134	13	mg-1	mg-1	NOUN
admet-3091	134	14	release	release	NOUN
admet-3091	134	15	at	at	ADP
admet-3091	134	16	5	5	NUM
admet-3091	134	17	wt.%	wt.%	ADJ
admet-3091	134	18	loading	loading	NOUN
admet-3091	134	19	versus	versus	ADP
admet-3091	134	20	0.44	0.44	NUM
admet-3091	134	21	to	to	PART
admet-3091	134	22	0.51	0.51	NUM
admet-3091	134	23	mg	mg	PROPN
admet-3091	134	24	mg-1	mg-1	NOUN
admet-3091	134	25	at	at	ADP
admet-3091	134	26	15	15	NUM
admet-3091	134	27	wt.%	wt.%	ADJ
admet-3091	134	28	loading	loading	NOUN
admet-3091	134	29	due	due	ADJ
admet-3091	134	30	to	to	ADP
admet-3091	134	31	higher	high	ADJ
admet-3091	134	32	surface	surface	NOUN
admet-3091	134	33	peptide	peptide	NOUN
admet-3091	134	34	density	density	NOUN
admet-3091	134	35	[	[	X
admet-3091	134	36	33	33	NUM
admet-3091	134	37	]	]	PUNCT
admet-3091	134	38	.	.	PUNCT
admet-3091	135	1	conversely	conversely	ADV
admet-3091	135	2	,	,	PUNCT
admet-3091	135	3	plectasin	plectasin	NOUN
admet-3091	135	4	-	-	PUNCT
admet-3091	135	5	loaded	load	VERB
admet-3091	135	6	plga	plga	NOUN
admet-3091	135	7	nanoparticles	nanoparticle	NOUN
admet-3091	135	8	showed	show	VERB
admet-3091	135	9	100	100	NUM
admet-3091	135	10	%	%	NOUN
admet-3091	135	11	burst	burst	NOUN
admet-3091	135	12	release	release	NOUN
admet-3091	135	13	at	at	ADP
admet-3091	135	14	0.625	0.625	NUM
admet-3091	135	15	wt.%	wt.%	ADJ
admet-3091	135	16	loading	loading	NOUN
admet-3091	135	17	versus	versus	ADP
admet-3091	135	18	77	77	NUM
admet-3091	135	19	%	%	NOUN
admet-3091	135	20	at	at	ADP
admet-3091	135	21	2.5	2.5	NUM
admet-3091	135	22	wt.%	wt.%	ADJ
admet-3091	135	23	loading	loading	NOUN
admet-3091	135	24	,	,	PUNCT
admet-3091	135	25	as	as	SCONJ
admet-3091	135	26	higher	high	ADJ
admet-3091	135	27	loading	loading	NOUN
admet-3091	135	28	shifted	shift	VERB
admet-3091	135	29	peptide	peptide	ADJ
admet-3091	135	30	distribution	distribution	NOUN
admet-3091	135	31	toward	toward	ADP
admet-3091	135	32	the	the	DET
admet-3091	135	33	core	core	NOUN
admet-3091	135	34	[	[	X
admet-3091	135	35	34	34	NUM
admet-3091	135	36	]	]	PUNCT
admet-3091	135	37	.	.	PUNCT
admet-3091	136	1	plga	plga	NOUN
admet-3091	136	2	microparticles	microparticle	NOUN
admet-3091	136	3	loaded	load	VERB
admet-3091	136	4	with	with	ADP
admet-3091	136	5	>	>	SYM
admet-3091	136	6	30	30	NUM
admet-3091	136	7	wt.%	wt.%	ADJ
admet-3091	136	8	protein	protein	NOUN
admet-3091	136	9	developed	develop	VERB
admet-3091	136	10	continuous	continuous	ADJ
admet-3091	136	11	pore	pore	ADJ
admet-3091	136	12	networks	network	NOUN
admet-3091	136	13	,	,	PUNCT
admet-3091	136	14	shifting	shift	VERB
admet-3091	136	15	release	release	NOUN
admet-3091	136	16	from	from	ADP
admet-3091	136	17	degradation	degradation	NOUN
admet-3091	136	18	-	-	PUNCT
admet-3091	136	19	controlled	control	VERB
admet-3091	136	20	to	to	ADP
admet-3091	136	21	diffusion	diffusion	NOUN
admet-3091	136	22	-	-	PUNCT
admet-3091	136	23	dominated	dominate	VERB
admet-3091	136	24	kinetics	kinetic	NOUN
admet-3091	136	25	.	.	PUNCT
admet-3091	137	1	high	high	ADJ
admet-3091	137	2	-	-	PUNCT
admet-3091	137	3	loading	loading	NOUN
admet-3091	137	4	vancomycin	vancomycin	PROPN
admet-3091	137	5	nanoparticles	nanoparticle	NOUN
admet-3091	137	6	(	(	PUNCT
admet-3091	137	7	90	90	NUM
admet-3091	137	8	wt.%	wt.%	NOUN
admet-3091	137	9	)	)	PUNCT
admet-3091	137	10	released	release	VERB
admet-3091	137	11	58	58	NUM
admet-3091	137	12	%	%	NOUN
admet-3091	137	13	of	of	ADP
admet-3091	137	14	the	the	DET
admet-3091	137	15	drug	drug	NOUN
admet-3091	137	16	within	within	ADP
admet-3091	137	17	24	24	NUM
admet-3091	137	18	hours	hour	NOUN
admet-3091	137	19	due	due	ADJ
admet-3091	137	20	to	to	ADP
admet-3091	137	21	interconnected	interconnected	ADJ
admet-3091	137	22	aqueous	aqueous	ADJ
admet-3091	137	23	channels	channel	NOUN
admet-3091	137	24	[	[	X
admet-3091	137	25	31	31	NUM
admet-3091	137	26	]	]	PUNCT
admet-3091	137	27	.	.	PUNCT
admet-3091	138	1	these	these	DET
admet-3091	138	2	findings	finding	NOUN
admet-3091	138	3	indicate	indicate	VERB
admet-3091	138	4	that	that	SCONJ
admet-3091	138	5	drug	drug	NOUN
admet-3091	138	6	loading	loading	NOUN
admet-3091	138	7	values	value	NOUN
admet-3091	138	8	can	can	AUX
admet-3091	138	9	be	be	AUX
admet-3091	138	10	optimized	optimize	VERB
admet-3091	138	11	to	to	PART
admet-3091	138	12	prevent	prevent	VERB
admet-3091	138	13	excessive	excessive	ADJ
admet-3091	138	14	burst	burst	ADJ
admet-3091	138	15	release	release	NOUN
admet-3091	138	16	and	and	CCONJ
admet-3091	138	17	ensure	ensure	VERB
admet-3091	138	18	controlled	control	VERB
admet-3091	138	19	rates	rate	NOUN
admet-3091	138	20	in	in	ADP
admet-3091	138	21	the	the	DET
admet-3091	138	22	sustained	sustain	VERB
admet-3091	138	23	-	-	PUNCT
admet-3091	138	24	release	release	NOUN
admet-3091	138	25	phase	phase	NOUN
admet-3091	138	26	.	.	PUNCT
admet-3091	139	1	while	while	SCONJ
admet-3091	139	2	too	too	ADV
admet-3091	139	3	low	low	ADJ
admet-3091	139	4	and	and	CCONJ
admet-3091	139	5	too	too	ADV
admet-3091	139	6	high	high	ADJ
admet-3091	139	7	drug	drug	NOUN
admet-3091	139	8	loadings	loading	NOUN
admet-3091	139	9	can	can	AUX
admet-3091	139	10	accelerate	accelerate	VERB
admet-3091	139	11	burst	burst	ADJ
admet-3091	139	12	and	and	CCONJ
admet-3091	139	13	sustained	sustained	ADJ
admet-3091	139	14	release	release	NOUN
admet-3091	139	15	,	,	PUNCT
admet-3091	139	16	respectively	respectively	ADV
admet-3091	139	17	,	,	PUNCT
admet-3091	139	18	an	an	DET
admet-3091	139	19	optimal	optimal	ADJ
admet-3091	139	20	loading	loading	NOUN
admet-3091	139	21	can	can	AUX
admet-3091	139	22	concentrate	concentrate	VERB
admet-3091	139	23	most	most	ADJ
admet-3091	139	24	of	of	ADP
admet-3091	139	25	the	the	DET
admet-3091	139	26	peptide	peptide	NOUN
admet-3091	139	27	cargo	cargo	NOUN
admet-3091	139	28	at	at	ADP
admet-3091	139	29	the	the	DET
admet-3091	139	30	particle	particle	NOUN
admet-3091	139	31	core	core	NOUN
admet-3091	139	32	to	to	PART
admet-3091	139	33	prevent	prevent	VERB
admet-3091	139	34	burst	burst	ADJ
admet-3091	139	35	release	release	NOUN
admet-3091	139	36	while	while	SCONJ
admet-3091	139	37	hindering	hinder	VERB
admet-3091	139	38	excessively	excessively	ADV
admet-3091	139	39	interconnected	interconnected	ADJ
admet-3091	139	40	network	network	NOUN
admet-3091	139	41	formation	formation	NOUN
admet-3091	139	42	,	,	PUNCT
admet-3091	139	43	which	which	PRON
admet-3091	139	44	can	can	AUX
admet-3091	139	45	trigger	trigger	NOUN
admet-3091	139	46	accelerated	accelerate	VERB
admet-3091	139	47	sustained	sustained	ADJ
admet-3091	139	48	release	release	NOUN
admet-3091	139	49	.	.	PUNCT
admet-3091	140	1	polymer	polymer	NOUN
admet-3091	140	2	concentration	concentration	NOUN
admet-3091	140	3	in	in	ADP
admet-3091	140	4	plga	plga	NOUN
admet-3091	140	5	formulations	formulation	NOUN
admet-3091	140	6	,	,	PUNCT
admet-3091	140	7	it	it	PRON
admet-3091	140	8	critically	critically	ADV
admet-3091	140	9	modulates	modulate	VERB
admet-3091	140	10	peptide	peptide	NOUN
admet-3091	140	11	release	release	NOUN
admet-3091	140	12	by	by	ADP
admet-3091	140	13	influencing	influence	VERB
admet-3091	140	14	matrix	matrix	NOUN
admet-3091	140	15	density	density	NOUN
admet-3091	140	16	,	,	PUNCT
admet-3091	140	17	pore	pore	ADJ
admet-3091	140	18	structure	structure	NOUN
admet-3091	140	19	,	,	PUNCT
admet-3091	140	20	and	and	CCONJ
admet-3091	140	21	degradation	degradation	NOUN
admet-3091	140	22	kinetics	kinetic	NOUN
admet-3091	140	23	.	.	PUNCT
admet-3091	141	1	higher	high	ADJ
admet-3091	141	2	plga	plga	NOUN
admet-3091	141	3	concentrations	concentration	NOUN
admet-3091	141	4	generally	generally	ADV
admet-3091	141	5	reduce	reduce	VERB
admet-3091	141	6	burst	burst	ADJ
admet-3091	141	7	release	release	NOUN
admet-3091	141	8	and	and	CCONJ
admet-3091	141	9	extend	extend	VERB
admet-3091	141	10	sustainedrelease	sustainedrelease	NOUN
admet-3091	141	11	duration	duration	NOUN
admet-3091	141	12	by	by	ADP
admet-3091	141	13	forming	form	VERB
admet-3091	141	14	denser	dense	ADJ
admet-3091	141	15	matrices	matrix	NOUN
admet-3091	141	16	with	with	ADP
admet-3091	141	17	limited	limited	ADJ
admet-3091	141	18	pore	pore	ADJ
admet-3091	141	19	interconnectivity	interconnectivity	NOUN
admet-3091	141	20	,	,	PUNCT
admet-3091	141	21	whereas	whereas	SCONJ
admet-3091	141	22	lower	low	ADJ
admet-3091	141	23	concentrations	concentration	NOUN
admet-3091	141	24	accelerate	accelerate	VERB
admet-3091	141	25	release	release	NOUN
admet-3091	141	26	through	through	ADP
admet-3091	141	27	increased	increase	VERB
admet-3091	141	28	porosity	porosity	NOUN
admet-3091	141	29	and	and	CCONJ
admet-3091	141	30	faster	fast	ADJ
admet-3091	141	31	solvent	solvent	NOUN
admet-3091	141	32	diffusion	diffusion	NOUN
admet-3091	141	33	[	[	X
admet-3091	141	34	31	31	NUM
admet-3091	141	35	]	]	PUNCT
admet-3091	141	36	.	.	PUNCT
admet-3091	142	1	this	this	DET
admet-3091	142	2	effect	effect	NOUN
admet-3091	142	3	must	must	AUX
admet-3091	142	4	be	be	AUX
admet-3091	142	5	balanced	balance	VERB
admet-3091	142	6	against	against	ADP
admet-3091	142	7	reduced	reduce	VERB
admet-3091	142	8	total	total	ADJ
admet-3091	142	9	loading	loading	NOUN
admet-3091	142	10	capacity	capacity	NOUN
admet-3091	142	11	.	.	PUNCT
admet-3091	143	1	for	for	ADP
admet-3091	143	2	buserelin	buserelin	PROPN
admet-3091	143	3	acetate	acetate	PROPN
admet-3091	143	4	ism	ism	NOUN
admet-3091	143	5	,	,	PUNCT
admet-3091	143	6	increasing	increase	VERB
admet-3091	143	7	plga	plga	NOUN
admet-3091	143	8	rg	rg	INTJ
admet-3091	143	9	502	502	NUM
admet-3091	143	10	concentration	concentration	NOUN
admet-3091	143	11	from	from	ADP
admet-3091	143	12	20	20	NUM
admet-3091	143	13	to	to	PART
admet-3091	143	14	40	40	NUM
admet-3091	143	15	%	%	NOUN
admet-3091	143	16	reduced	reduce	VERB
admet-3091	143	17	burst	burst	ADJ
admet-3091	143	18	release	release	NOUN
admet-3091	143	19	from	from	ADP
admet-3091	143	20	49.3	49.3	NUM
admet-3091	143	21	to	to	ADP
admet-3091	143	22	25.4	25.4	NUM
admet-3091	143	23	%	%	NOUN
admet-3091	143	24	within	within	ADP
admet-3091	143	25	24	24	NUM
admet-3091	143	26	hours	hour	NOUN
admet-3091	143	27	by	by	ADP
admet-3091	143	28	limiting	limit	VERB
admet-3091	143	29	solvent	solvent	ADJ
admet-3091	143	30	diffusion	diffusion	NOUN
admet-3091	143	31	and	and	CCONJ
admet-3091	143	32	promoting	promote	VERB
admet-3091	143	33	denser	dense	ADJ
admet-3091	143	34	particle	particle	NOUN
admet-3091	143	35	formation	formation	NOUN
admet-3091	143	36	[	[	X
admet-3091	143	37	11	11	NUM
admet-3091	143	38	]	]	PUNCT
admet-3091	143	39	.	.	PUNCT
admet-3091	144	1	albumin	albumin	NOUN
admet-3091	144	2	-	-	PUNCT
admet-3091	144	3	loaded	load	VERB
admet-3091	144	4	plga	plga	NOUN
admet-3091	144	5	microparticles	microparticle	NOUN
admet-3091	144	6	with	with	ADP
admet-3091	144	7	10	10	NUM
admet-3091	144	8	%	%	NOUN
admet-3091	144	9	polymer	polymer	NOUN
admet-3091	144	10	concentration	concentration	NOUN
admet-3091	144	11	released	release	VERB
admet-3091	144	12	over	over	ADP
admet-3091	144	13	14	14	NUM
admet-3091	144	14	days	day	NOUN
admet-3091	144	15	,	,	PUNCT
admet-3091	144	16	while	while	SCONJ
admet-3091	144	17	5	5	NUM
admet-3091	144	18	%	%	NOUN
admet-3091	144	19	concentration	concentration	NOUN
admet-3091	144	20	formulations	formulation	NOUN
admet-3091	144	21	completed	complete	VERB
admet-3091	144	22	release	release	NOUN
admet-3091	144	23	in	in	ADP
admet-3091	144	24	7	7	NUM
admet-3091	144	25	days	day	NOUN
admet-3091	144	26	[	[	X
admet-3091	144	27	35	35	NUM
admet-3091	144	28	]	]	PUNCT
admet-3091	144	29	.	.	PUNCT
admet-3091	145	1	additives	additive	NOUN
admet-3091	145	2	and	and	CCONJ
admet-3091	145	3	excipients	excipient	VERB
admet-3091	145	4	various	various	ADJ
admet-3091	145	5	additives	additive	NOUN
admet-3091	145	6	can	can	AUX
admet-3091	145	7	modulate	modulate	VERB
admet-3091	145	8	release	release	NOUN
admet-3091	145	9	profiles	profile	NOUN
admet-3091	145	10	in	in	ADP
admet-3091	145	11	different	different	ADJ
admet-3091	145	12	ways	way	NOUN
admet-3091	145	13	.	.	PUNCT
admet-3091	146	1	medium	medium	ADJ
admet-3091	146	2	-	-	PUNCT
admet-3091	146	3	chain	chain	NOUN
admet-3091	146	4	triglycerides	triglyceride	NOUN
admet-3091	146	5	(	(	PUNCT
admet-3091	146	6	mcts	mct	NOUN
admet-3091	146	7	)	)	PUNCT
admet-3091	146	8	create	create	VERB
admet-3091	146	9	porous	porous	ADJ
admet-3091	146	10	internal	internal	ADJ
admet-3091	146	11	structures	structure	NOUN
admet-3091	146	12	,	,	PUNCT
admet-3091	146	13	shifting	shift	VERB
admet-3091	146	14	from	from	ADP
admet-3091	146	15	triphasic	triphasic	ADJ
admet-3091	146	16	to	to	ADP
admet-3091	146	17	continuous	continuous	ADJ
admet-3091	146	18	biphasic	biphasic	ADJ
admet-3091	146	19	release	release	NOUN
admet-3091	146	20	profiles	profile	NOUN
admet-3091	146	21	.	.	PUNCT
admet-3091	147	1	in	in	ADP
admet-3091	147	2	leuprolide	leuprolide	NOUN
admet-3091	147	3	microparticles	microparticle	NOUN
admet-3091	147	4	,	,	PUNCT
admet-3091	147	5	20	20	NUM
admet-3091	147	6	%	%	NOUN
admet-3091	147	7	mct	mct	PROPN
admet-3091	147	8	increased	increase	VERB
admet-3091	147	9	intermediate	intermediate	ADJ
admet-3091	147	10	-	-	PUNCT
admet-3091	147	11	phase	phase	NOUN
admet-3091	147	12	release	release	NOUN
admet-3091	147	13	from	from	ADP
admet-3091	147	14	25	25	NUM
admet-3091	147	15	to	to	PART
admet-3091	147	16	45	45	NUM
admet-3091	147	17	%	%	NOUN
admet-3091	147	18	and	and	CCONJ
admet-3091	147	19	reduced	reduce	VERB
admet-3091	147	20	final	final	ADJ
admet-3091	147	21	-	-	PUNCT
admet-3091	147	22	phase	phase	NOUN
admet-3091	147	23	admet	admet	NOUN
admet-3091	147	24	&	&	CCONJ
admet-3091	147	25	dmpk	dmpk	PROPN
admet-3091	147	26	00(0	00(0	PROPN
admet-3091	147	27	)	)	PUNCT
admet-3091	147	28	(	(	PUNCT
admet-3091	147	29	2025	2025	NUM
admet-3091	147	30	)	)	PUNCT
admet-3091	147	31	3091	3091	NUM
admet-3091	147	32	plga	plga	NOUN
admet-3091	147	33	nanoparticles	nanoparticle	NOUN
admet-3091	147	34	and	and	CCONJ
admet-3091	147	35	microparticles	microparticle	NOUN
admet-3091	147	36	for	for	ADP
admet-3091	147	37	peptide	peptide	ADJ
admet-3091	147	38	delivery	delivery	NOUN
admet-3091	147	39	doi	doi	NOUN
admet-3091	147	40	:	:	PUNCT
admet-3091	147	41	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	147	42	7	7	NUM
admet-3091	147	43	release	release	NOUN
admet-3091	147	44	from	from	ADP
admet-3091	147	45	57	57	NUM
admet-3091	147	46	to	to	PART
admet-3091	147	47	28	28	NUM
admet-3091	147	48	%	%	NOUN
admet-3091	147	49	[	[	X
admet-3091	147	50	36	36	NUM
admet-3091	147	51	]	]	PUNCT
admet-3091	147	52	.	.	PUNCT
admet-3091	148	1	for	for	ADP
admet-3091	148	2	endostar	endostar	NOUN
admet-3091	148	3	,	,	PUNCT
admet-3091	148	4	mct	mct	PROPN
admet-3091	148	5	co	co	NOUN
admet-3091	148	6	-	-	NOUN
admet-3091	148	7	encapsulation	encapsulation	NOUN
admet-3091	148	8	improved	improve	VERB
admet-3091	148	9	in	in	ADP
admet-3091	148	10	vitro	vitro	X
admet-3091	148	11	release	release	NOUN
admet-3091	148	12	from	from	ADP
admet-3091	148	13	32.22	32.22	NUM
admet-3091	148	14	%	%	NOUN
admet-3091	148	15	to	to	ADP
admet-3091	148	16	79.04	79.04	NUM
admet-3091	148	17	%	%	NOUN
admet-3091	148	18	over	over	ADP
admet-3091	148	19	30	30	NUM
admet-3091	148	20	days	day	NOUN
admet-3091	148	21	and	and	CCONJ
admet-3091	148	22	reduced	reduce	VERB
admet-3091	148	23	peptide	peptide	ADJ
admet-3091	148	24	retention	retention	NOUN
admet-3091	148	25	in	in	ADP
admet-3091	148	26	vivo	vivo	NOUN
admet-3091	148	27	from	from	ADP
admet-3091	148	28	42.25	42.25	NUM
admet-3091	148	29	to	to	PART
admet-3091	148	30	9.87	9.87	NUM
admet-3091	148	31	%	%	NOUN
admet-3091	149	1	[	[	X
admet-3091	149	2	37	37	NUM
admet-3091	149	3	]	]	PUNCT
admet-3091	149	4	.	.	PUNCT
admet-3091	150	1	peg	peg	NOUN
admet-3091	150	2	incorporation	incorporation	NOUN
admet-3091	150	3	increases	increase	VERB
admet-3091	150	4	matrix	matrix	NOUN
admet-3091	150	5	porosity	porosity	NOUN
admet-3091	150	6	and	and	CCONJ
admet-3091	150	7	enhances	enhance	VERB
admet-3091	150	8	water	water	NOUN
admet-3091	150	9	uptake	uptake	NOUN
admet-3091	150	10	,	,	PUNCT
admet-3091	150	11	thereby	thereby	ADV
admet-3091	150	12	accelerating	accelerate	VERB
admet-3091	150	13	release	release	NOUN
admet-3091	150	14	.	.	PUNCT
admet-3091	151	1	high	high	ADJ
admet-3091	151	2	peg	peg	NOUN
admet-3091	151	3	content	content	NOUN
admet-3091	151	4	(	(	PUNCT
admet-3091	151	5	peg	peg	NOUN
admet-3091	151	6	:	:	PUNCT
admet-3091	151	7	la+ga	la+ga	X
admet-3091	151	8	=	=	SYM
admet-3091	151	9	1:8	1:8	NUM
admet-3091	151	10	)	)	PUNCT
admet-3091	151	11	increased	increase	VERB
admet-3091	151	12	tnfr	tnfr	NUM
admet-3091	151	13	-	-	PUNCT
admet-3091	151	14	bp	bp	NOUN
admet-3091	151	15	burst	burst	NOUN
admet-3091	151	16	release	release	NOUN
admet-3091	151	17	to	to	ADP
admet-3091	151	18	39.4	39.4	NUM
admet-3091	151	19	%	%	NOUN
admet-3091	151	20	within	within	ADP
admet-3091	151	21	10	10	NUM
admet-3091	151	22	hours	hour	NOUN
admet-3091	151	23	,	,	PUNCT
admet-3091	151	24	compared	compare	VERB
admet-3091	151	25	with	with	ADP
admet-3091	151	26	26.7	26.7	NUM
admet-3091	151	27	%	%	NOUN
admet-3091	151	28	for	for	ADP
admet-3091	151	29	lowpeg	lowpeg	NOUN
admet-3091	151	30	systems	system	NOUN
admet-3091	151	31	[	[	X
admet-3091	151	32	32,38	32,38	X
admet-3091	151	33	]	]	PUNCT
admet-3091	151	34	.	.	PUNCT
admet-3091	152	1	co	co	NOUN
admet-3091	152	2	-	-	NOUN
admet-3091	152	3	encapsulation	encapsulation	NOUN
admet-3091	152	4	of	of	ADP
admet-3091	152	5	magnesium	magnesium	NOUN
admet-3091	152	6	carbonate	carbonate	NOUN
admet-3091	152	7	reduces	reduce	VERB
admet-3091	152	8	peptide	peptide	NOUN
admet-3091	152	9	denaturation	denaturation	NOUN
admet-3091	152	10	risk	risk	NOUN
admet-3091	152	11	by	by	ADP
admet-3091	152	12	40	40	NUM
admet-3091	152	13	%	%	NOUN
admet-3091	152	14	in	in	ADP
admet-3091	152	15	glycolide	glycolide	NOUN
admet-3091	152	16	-	-	PUNCT
admet-3091	152	17	rich	rich	ADJ
admet-3091	152	18	plga	plga	NOUN
admet-3091	152	19	,	,	PUNCT
admet-3091	152	20	stabilizing	stabilize	VERB
admet-3091	152	21	ph	ph	ADJ
admet-3091	152	22	-	-	ADJ
admet-3091	152	23	sensitive	sensitive	ADJ
admet-3091	152	24	peptides	peptide	NOUN
admet-3091	152	25	like	like	INTJ
admet-3091	152	26	exenatide	exenatide	VERB
admet-3091	153	1	[	[	X
admet-3091	153	2	25	25	NUM
admet-3091	153	3	]	]	PUNCT
admet-3091	153	4	.	.	PUNCT
admet-3091	154	1	when	when	SCONJ
admet-3091	154	2	using	use	VERB
admet-3091	154	3	pva	pva	NOUN
admet-3091	154	4	as	as	ADP
admet-3091	154	5	an	an	DET
admet-3091	154	6	emulsifier	emulsifier	NOUN
admet-3091	154	7	,	,	PUNCT
admet-3091	154	8	higher	high	ADJ
admet-3091	154	9	hydrolysis	hydrolysis	NOUN
admet-3091	154	10	(	(	PUNCT
admet-3091	154	11	87	87	NUM
admet-3091	154	12	to	to	PART
admet-3091	154	13	89	89	NUM
admet-3091	154	14	%	%	NOUN
admet-3091	154	15	)	)	PUNCT
admet-3091	154	16	reduces	reduce	VERB
admet-3091	154	17	nanoparticle	nanoparticle	NOUN
admet-3091	154	18	pdi	pdi	PROPN
admet-3091	154	19	to	to	ADP
admet-3091	154	20	0.044	0.044	NUM
admet-3091	154	21	,	,	PUNCT
admet-3091	154	22	enabling	enable	VERB
admet-3091	154	23	uniform	uniform	NOUN
admet-3091	154	24	,	,	PUNCT
admet-3091	154	25	sustained	sustain	VERB
admet-3091	154	26	release	release	NOUN
admet-3091	154	27	of	of	ADP
admet-3091	154	28	antimicrobial	antimicrobial	ADJ
admet-3091	154	29	peptides	peptide	NOUN
admet-3091	154	30	such	such	ADJ
admet-3091	154	31	as	as	ADP
admet-3091	154	32	ctn	ctn	NOUN
admet-3091	154	33	[	[	X
admet-3091	154	34	15	15	NUM
admet-3091	154	35	-	-	SYM
admet-3091	154	36	34,39	34,39	NUM
admet-3091	154	37	]	]	PUNCT
admet-3091	154	38	.	.	PUNCT
admet-3091	155	1	phenylalanine	phenylalanine	NOUN
admet-3091	155	2	-	-	PUNCT
admet-3091	155	3	grafting	grafting	NOUN
admet-3091	155	4	reduces	reduce	VERB
admet-3091	155	5	burst	burst	ADJ
admet-3091	155	6	release	release	NOUN
admet-3091	155	7	from	from	ADP
admet-3091	155	8	50	50	NUM
admet-3091	155	9	to	to	ADP
admet-3091	155	10	<	<	X
admet-3091	155	11	10	10	NUM
admet-3091	155	12	%	%	NOUN
admet-3091	155	13	by	by	ADP
admet-3091	155	14	enhancing	enhance	VERB
admet-3091	155	15	hydrophobic	hydrophobic	NOUN
admet-3091	155	16	peptide	peptide	NOUN
admet-3091	155	17	interactions	interaction	NOUN
admet-3091	155	18	[	[	X
admet-3091	155	19	27	27	NUM
admet-3091	155	20	]	]	PUNCT
admet-3091	155	21	.	.	PUNCT
admet-3091	156	1	lyoprotectants	lyoprotectant	NOUN
admet-3091	156	2	can	can	AUX
admet-3091	156	3	prevent	prevent	VERB
admet-3091	156	4	peptide	peptide	ADJ
admet-3091	156	5	aggregation	aggregation	NOUN
admet-3091	156	6	during	during	ADP
admet-3091	156	7	freeze	freeze	NOUN
admet-3091	156	8	-	-	PUNCT
admet-3091	156	9	drying	dry	VERB
admet-3091	156	10	and	and	CCONJ
admet-3091	156	11	reduce	reduce	VERB
admet-3091	156	12	burst	burst	ADJ
admet-3091	156	13	release	release	NOUN
admet-3091	156	14	,	,	PUNCT
admet-3091	156	15	maintaining	maintain	VERB
admet-3091	156	16	release	release	NOUN
admet-3091	156	17	consistency	consistency	NOUN
admet-3091	156	18	.	.	PUNCT
admet-3091	157	1	in	in	ADP
admet-3091	157	2	plga	plga	NOUN
admet-3091	157	3	microparticles	microparticle	NOUN
admet-3091	157	4	,	,	PUNCT
admet-3091	157	5	trehalose	trehalose	DET
admet-3091	157	6	reduced	reduce	VERB
admet-3091	157	7	post	post	ADJ
admet-3091	157	8	-	-	ADJ
admet-3091	157	9	lyophilization	lyophilization	ADJ
admet-3091	157	10	size	size	NOUN
admet-3091	157	11	increase	increase	NOUN
admet-3091	157	12	by	by	ADP
admet-3091	157	13	30	30	NUM
admet-3091	157	14	%	%	NOUN
admet-3091	157	15	during	during	ADP
admet-3091	157	16	storage	storage	NOUN
admet-3091	157	17	.	.	PUNCT
admet-3091	158	1	cyclodextrins	cyclodextrin	NOUN
admet-3091	158	2	reduced	reduce	VERB
admet-3091	158	3	burst	burst	ADJ
admet-3091	158	4	release	release	NOUN
admet-3091	158	5	by	by	ADP
admet-3091	158	6	15	15	NUM
admet-3091	158	7	to	to	PART
admet-3091	158	8	20	20	NUM
admet-3091	158	9	%	%	NOUN
admet-3091	158	10	via	via	ADP
admet-3091	158	11	hydrophobic	hydrophobic	ADJ
admet-3091	158	12	complexation	complexation	NOUN
admet-3091	158	13	with	with	ADP
admet-3091	158	14	peptides	peptide	NOUN
admet-3091	158	15	[	[	X
admet-3091	158	16	25,40	25,40	NUM
admet-3091	158	17	]	]	PUNCT
admet-3091	158	18	.	.	PUNCT
admet-3091	159	1	chitosan	chitosan	NOUN
admet-3091	159	2	coating	coating	NOUN
admet-3091	159	3	significantly	significantly	ADV
admet-3091	159	4	reduces	reduce	VERB
admet-3091	159	5	initial	initial	ADJ
admet-3091	159	6	burst	burst	ADJ
admet-3091	159	7	release	release	NOUN
admet-3091	159	8	by	by	ADP
admet-3091	159	9	forming	form	VERB
admet-3091	159	10	a	a	DET
admet-3091	159	11	network	network	NOUN
admet-3091	159	12	that	that	PRON
admet-3091	159	13	restricts	restrict	VERB
admet-3091	159	14	water	water	NOUN
admet-3091	159	15	infiltration	infiltration	NOUN
admet-3091	159	16	and	and	CCONJ
admet-3091	159	17	peptide	peptide	NOUN
admet-3091	159	18	diffusion	diffusion	NOUN
admet-3091	159	19	.	.	PUNCT
admet-3091	160	1	in	in	ADP
admet-3091	160	2	recombinant	recombinant	ADJ
admet-3091	160	3	human	human	ADJ
admet-3091	160	4	interleukin-2	interleukin-2	NOUN
admet-3091	160	5	)	)	PUNCT
admet-3091	160	6	rhil-2	rhil-2	VERB
admet-3091	160	7	(	(	PUNCT
admet-3091	160	8	delivery	delivery	NOUN
admet-3091	160	9	systems	system	NOUN
admet-3091	160	10	,	,	PUNCT
admet-3091	160	11	chitosan	chitosan	NOUN
admet-3091	160	12	coating	coating	NOUN
admet-3091	160	13	reduced	reduce	VERB
admet-3091	160	14	burst	burst	ADJ
admet-3091	160	15	release	release	NOUN
admet-3091	160	16	from	from	ADP
admet-3091	160	17	70.18	70.18	NUM
admet-3091	160	18	to	to	ADP
admet-3091	160	19	44.85	44.85	NUM
admet-3091	160	20	%	%	NOUN
admet-3091	161	1	[	[	X
admet-3091	161	2	41	41	NUM
admet-3091	161	3	-	-	SYM
admet-3091	161	4	43	43	NUM
admet-3091	161	5	]	]	PUNCT
admet-3091	161	6	.	.	PUNCT
admet-3091	162	1	polycationic	polycationic	ADJ
admet-3091	162	2	coatings	coating	NOUN
admet-3091	162	3	,	,	PUNCT
admet-3091	162	4	such	such	ADJ
admet-3091	162	5	as	as	ADP
admet-3091	162	6	quaternized	quaternize	VERB
admet-3091	162	7	poly(4	poly(4	PROPN
admet-3091	162	8	-	-	PUNCT
admet-3091	162	9	vinylpyridine	vinylpyridine	NOUN
admet-3091	162	10	)	)	PUNCT
admet-3091	162	11	(	(	PUNCT
admet-3091	162	12	qpvp	qpvp	NOUN
admet-3091	162	13	)	)	PUNCT
admet-3091	162	14	,	,	PUNCT
admet-3091	162	15	alter	alter	VERB
admet-3091	162	16	release	release	NOUN
admet-3091	162	17	dynamics	dynamic	NOUN
admet-3091	162	18	by	by	ADP
admet-3091	162	19	enhancing	enhance	VERB
admet-3091	162	20	water	water	NOUN
admet-3091	162	21	penetration	penetration	NOUN
admet-3091	162	22	and	and	CCONJ
admet-3091	162	23	modifying	modify	VERB
admet-3091	162	24	surface	surface	NOUN
admet-3091	162	25	charge	charge	NOUN
admet-3091	162	26	.	.	PUNCT
admet-3091	163	1	while	while	SCONJ
admet-3091	163	2	coated	coated	ADJ
admet-3091	163	3	nanoparticles	nanoparticle	NOUN
admet-3091	163	4	showed	show	VERB
admet-3091	163	5	lower	low	ADJ
admet-3091	163	6	initial	initial	ADJ
admet-3091	163	7	burst	burst	NOUN
admet-3091	163	8	(	(	PUNCT
admet-3091	163	9	4	4	NUM
admet-3091	163	10	vs.	vs.	ADP
admet-3091	163	11	9	9	NUM
admet-3091	163	12	%	%	NOUN
admet-3091	163	13	for	for	ADP
admet-3091	163	14	uncoated	uncoated	ADJ
admet-3091	163	15	)	)	PUNCT
admet-3091	163	16	,	,	PUNCT
admet-3091	163	17	they	they	PRON
admet-3091	163	18	demonstrated	demonstrate	VERB
admet-3091	163	19	sustained	sustained	ADJ
admet-3091	163	20	release	release	NOUN
admet-3091	163	21	profiles	profile	NOUN
admet-3091	163	22	with	with	ADP
admet-3091	163	23	enhanced	enhanced	ADJ
admet-3091	163	24	degradation	degradation	NOUN
admet-3091	163	25	[	[	X
admet-3091	163	26	44	44	NUM
admet-3091	163	27	]	]	PUNCT
admet-3091	163	28	.	.	PUNCT
admet-3091	164	1	factors	factor	NOUN
admet-3091	164	2	affecting	affect	VERB
admet-3091	164	3	peptide	peptide	ADJ
admet-3091	164	4	release	release	NOUN
admet-3091	164	5	from	from	ADP
admet-3091	164	6	plga	plga	NOUN
admet-3091	164	7	nanoparticles	nanoparticle	NOUN
admet-3091	164	8	and	and	CCONJ
admet-3091	164	9	microparticles	microparticle	NOUN
admet-3091	164	10	are	be	AUX
admet-3091	164	11	shown	show	VERB
admet-3091	164	12	in	in	ADP
admet-3091	164	13	table	table	NOUN
admet-3091	164	14	1	1	NUM
admet-3091	164	15	.	.	PUNCT
admet-3091	164	16	table	table	NOUN
admet-3091	164	17	1	1	NUM
admet-3091	164	18	.	.	PUNCT
admet-3091	165	1	factors	factor	NOUN
admet-3091	165	2	influencing	influence	VERB
admet-3091	165	3	peptide	peptide	ADJ
admet-3091	165	4	release	release	NOUN
admet-3091	165	5	from	from	ADP
admet-3091	165	6	plga	plga	NOUN
admet-3091	165	7	nano	nano	NOUN
admet-3091	165	8	and	and	CCONJ
admet-3091	165	9	microparticles	microparticle	NOUN
admet-3091	165	10	factor	factor	NOUN
admet-3091	165	11	impact	impact	NOUN
admet-3091	165	12	on	on	ADP
admet-3091	165	13	release	release	NOUN
admet-3091	165	14	mechanism	mechanism	NOUN
admet-3091	165	15	optimization	optimization	NOUN
admet-3091	165	16	strategy	strategy	NOUN
admet-3091	165	17	plga	plga	NOUN
admet-3091	165	18	mw	mw	X
admet-3091	165	19	higher	high	ADJ
admet-3091	165	20	mw	mw	X
admet-3091	165	21	correlates	correlate	NOUN
admet-3091	165	22	with	with	ADP
admet-3091	165	23	slower	slow	ADJ
admet-3091	165	24	release	release	NOUN
admet-3091	165	25	delayed	delay	VERB
admet-3091	165	26	degradation	degradation	NOUN
admet-3091	165	27	rate	rate	NOUN
admet-3091	165	28	at	at	ADP
admet-3091	165	29	higher	high	ADJ
admet-3091	165	30	mw	mw	ADJ
admet-3091	165	31	commercial	commercial	ADJ
admet-3091	165	32	plga	plga	NOUN
admet-3091	165	33	products	product	NOUN
admet-3091	165	34	with	with	ADP
admet-3091	165	35	various	various	ADJ
admet-3091	165	36	mws	mws	NOUN
admet-3091	165	37	are	be	AUX
admet-3091	165	38	available	available	ADJ
admet-3091	165	39	mix	mix	NOUN
admet-3091	165	40	multiple	multiple	ADJ
admet-3091	165	41	mw	mw	NOUN
admet-3091	165	42	ranges	range	NOUN
admet-3091	165	43	for	for	ADP
admet-3091	165	44	particle	particle	NOUN
admet-3091	165	45	synthesis	synthesis	NOUN
admet-3091	165	46	to	to	ADP
admet-3091	165	47	tune	tune	NOUN
admet-3091	165	48	release	release	NOUN
admet-3091	165	49	rate	rate	NOUN
admet-3091	165	50	monomer	monomer	NOUN
admet-3091	165	51	ratio	ratio	NOUN
admet-3091	165	52	(	(	PUNCT
admet-3091	165	53	lactide	lactide	ADV
admet-3091	165	54	:	:	PUNCT
admet-3091	165	55	glycolide	glycolide	ADJ
admet-3091	165	56	)	)	PUNCT
admet-3091	165	57	higher	high	ADJ
admet-3091	165	58	lactide	lactide	PROPN
admet-3091	165	59	content	content	NOUN
admet-3091	165	60	correlates	correlate	VERB
admet-3091	165	61	with	with	ADP
admet-3091	165	62	slower	slow	ADJ
admet-3091	165	63	release	release	NOUN
admet-3091	165	64	delayed	delay	VERB
admet-3091	165	65	degradation	degradation	NOUN
admet-3091	165	66	rate	rate	NOUN
admet-3091	165	67	due	due	ADP
admet-3091	165	68	to	to	ADP
admet-3091	165	69	higher	high	ADJ
admet-3091	165	70	hydrophobicity	hydrophobicity	NOUN
admet-3091	165	71	higher	high	ADJ
admet-3091	165	72	ratios	ratio	NOUN
admet-3091	165	73	(	(	PUNCT
admet-3091	165	74	85:15	85:15	NUM
admet-3091	165	75	,	,	PUNCT
admet-3091	165	76	75:25	75:25	NUM
admet-3091	165	77	)	)	PUNCT
admet-3091	165	78	for	for	ADP
admet-3091	165	79	chronic	chronic	ADJ
admet-3091	165	80	conditions	condition	NOUN
admet-3091	165	81	and	and	CCONJ
admet-3091	165	82	lower	low	ADJ
admet-3091	165	83	ratios	ratio	NOUN
admet-3091	165	84	(	(	PUNCT
admet-3091	165	85	50:50	50:50	NUM
admet-3091	165	86	,	,	PUNCT
admet-3091	165	87	65:35	65:35	NUM
admet-3091	165	88	)	)	PUNCT
admet-3091	165	89	for	for	ADP
admet-3091	165	90	acute	acute	ADJ
admet-3091	165	91	conditions	condition	NOUN
admet-3091	165	92	particle	particle	NOUN
admet-3091	165	93	size	size	NOUN
admet-3091	165	94	smaller	small	ADJ
admet-3091	165	95	size	size	NOUN
admet-3091	165	96	correlates	correlate	VERB
admet-3091	165	97	with	with	ADP
admet-3091	165	98	faster	fast	ADJ
admet-3091	165	99	release	release	NOUN
admet-3091	165	100	higher	high	ADJ
admet-3091	165	101	surface	surface	NOUN
admet-3091	165	102	-	-	PUNCT
admet-3091	165	103	to	to	ADP
admet-3091	165	104	-	-	PUNCT
admet-3091	165	105	volume	volume	NOUN
admet-3091	165	106	ratios	ratio	NOUN
admet-3091	165	107	favour	favour	VERB
admet-3091	165	108	surface	surface	NOUN
admet-3091	165	109	adsorption	adsorption	NOUN
admet-3091	165	110	rather	rather	ADV
admet-3091	165	111	than	than	ADP
admet-3091	165	112	core	core	NOUN
admet-3091	165	113	encapsulation	encapsulation	NOUN
admet-3091	165	114	microparticles	microparticle	NOUN
admet-3091	165	115	suit	suit	NOUN
admet-3091	165	116	sustained	sustain	VERB
admet-3091	165	117	release	release	NOUN
admet-3091	165	118	applications	application	NOUN
admet-3091	165	119	(	(	PUNCT
admet-3091	165	120	chronic	chronic	NOUN
admet-3091	165	121	)	)	PUNCT
admet-3091	165	122	while	while	SCONJ
admet-3091	165	123	nanoparticles	nanoparticle	NOUN
admet-3091	165	124	favour	favour	VERB
admet-3091	165	125	fast	fast	ADJ
admet-3091	165	126	release	release	NOUN
admet-3091	165	127	applications	application	NOUN
admet-3091	165	128	(	(	PUNCT
admet-3091	165	129	acute	acute	NOUN
admet-3091	165	130	)	)	PUNCT
admet-3091	165	131	plga	plga	NOUN
admet-3091	165	132	carboxylate	carboxylate	NOUN
admet-3091	165	133	end	end	NOUN
admet-3091	165	134	-	-	PUNCT
admet-3091	165	135	group	group	NOUN
admet-3091	165	136	promotes	promote	VERB
admet-3091	165	137	slower	slow	ADJ
admet-3091	165	138	release	release	NOUN
admet-3091	165	139	electrostatic	electrostatic	ADJ
admet-3091	165	140	interactions	interaction	NOUN
admet-3091	165	141	with	with	ADP
admet-3091	165	142	basic	basic	ADJ
admet-3091	165	143	residues	residue	NOUN
admet-3091	165	144	co	co	NOUN
admet-3091	165	145	-	-	NOUN
admet-3091	165	146	encapsulation	encapsulation	NOUN
admet-3091	165	147	of	of	ADP
admet-3091	165	148	basic	basic	ADJ
admet-3091	165	149	additives	additive	NOUN
admet-3091	165	150	plga	plga	VERB
admet-3091	165	151	ester	ester	NOUN
admet-3091	165	152	end	end	NOUN
admet-3091	165	153	-	-	PUNCT
admet-3091	165	154	group	group	NOUN
admet-3091	165	155	generally	generally	ADV
admet-3091	165	156	,	,	PUNCT
admet-3091	165	157	promotes	promote	VERB
admet-3091	165	158	faster	fast	ADJ
admet-3091	165	159	release	release	NOUN
admet-3091	165	160	than	than	ADP
admet-3091	165	161	carboxylate	carboxylate	NOUN
admet-3091	165	162	plga	plga	NOUN
admet-3091	165	163	lack	lack	NOUN
admet-3091	165	164	of	of	ADP
admet-3091	165	165	electrostatic	electrostatic	ADJ
admet-3091	165	166	affinity	affinity	NOUN
admet-3091	165	167	–	–	PUNCT
admet-3091	165	168	could	could	AUX
admet-3091	165	169	form	form	VERB
admet-3091	165	170	covalent	covalent	NOUN
admet-3091	165	171	adducts	adduct	NOUN
admet-3091	165	172	with	with	ADP
admet-3091	165	173	nucleophilic	nucleophilic	ADJ
admet-3091	165	174	peptide	peptide	NOUN
admet-3091	165	175	residues	residue	NOUN
admet-3091	165	176	and	and	CCONJ
admet-3091	165	177	impede	impede	VERB
admet-3091	165	178	release	release	NOUN
admet-3091	165	179	co	co	NOUN
admet-3091	165	180	-	-	NOUN
admet-3091	165	181	encapsulation	encapsulation	NOUN
admet-3091	165	182	of	of	ADP
admet-3091	165	183	basic	basic	ADJ
admet-3091	165	184	additives	additive	NOUN
admet-3091	165	185	peptide	peptide	ADJ
admet-3091	165	186	size	size	NOUN
admet-3091	165	187	lower	low	ADJ
admet-3091	165	188	mw	mw	NOUN
admet-3091	165	189	(	(	PUNCT
admet-3091	165	190	<	<	X
admet-3091	165	191	10	10	NUM
admet-3091	165	192	kda	kda	NOUN
admet-3091	165	193	)	)	PUNCT
admet-3091	165	194	correlates	correlate	VERB
admet-3091	165	195	with	with	ADP
admet-3091	165	196	faster	fast	ADJ
admet-3091	165	197	release	release	NOUN
admet-3091	165	198	reduced	reduce	VERB
admet-3091	165	199	steric	steric	ADJ
admet-3091	165	200	hindrance	hindrance	NOUN
admet-3091	165	201	restricted	restrict	VERB
admet-3091	165	202	to	to	ADP
admet-3091	165	203	therapeutic	therapeutic	ADJ
admet-3091	165	204	needs	need	NOUN
admet-3091	165	205	peptide	peptide	NOUN
admet-3091	165	206	charge	charge	NOUN
admet-3091	165	207	positive	positive	ADJ
admet-3091	165	208	charge	charge	NOUN
admet-3091	165	209	correlates	correlate	VERB
admet-3091	165	210	with	with	ADP
admet-3091	165	211	slower	slow	ADJ
admet-3091	165	212	release	release	NOUN
admet-3091	165	213	electrostatic	electrostatic	ADJ
admet-3091	165	214	interaction	interaction	NOUN
admet-3091	165	215	with	with	ADP
admet-3091	165	216	plga	plga	NOUN
admet-3091	165	217	-	-	PUNCT
admet-3091	165	218	degradation	degradation	NOUN
admet-3091	165	219	metabolites	metabolite	NOUN
admet-3091	165	220	restricted	restrict	VERB
admet-3091	165	221	to	to	ADP
admet-3091	165	222	therapeutic	therapeutic	ADJ
admet-3091	165	223	needs	need	NOUN
admet-3091	165	224	peptide	peptide	NOUN
admet-3091	165	225	structure	structure	NOUN
admet-3091	165	226	hydrophobicity	hydrophobicity	NOUN
admet-3091	165	227	correlates	correlate	VERB
admet-3091	165	228	with	with	ADP
admet-3091	165	229	slower	slow	ADJ
admet-3091	165	230	release	release	NOUN
admet-3091	165	231	hydrophobic	hydrophobic	NOUN
admet-3091	165	232	interaction	interaction	NOUN
admet-3091	165	233	with	with	ADP
admet-3091	165	234	the	the	DET
admet-3091	165	235	plga	plga	NOUN
admet-3091	165	236	matrix	matrix	NOUN
admet-3091	165	237	adjust	adjust	VERB
admet-3091	165	238	monomer	monomer	NOUN
admet-3091	165	239	ratio	ratio	NOUN
admet-3091	165	240	to	to	PART
admet-3091	165	241	modulate	modulate	VERB
admet-3091	165	242	plga	plga	NOUN
admet-3091	165	243	hydrophobicity	hydrophobicity	NOUN
admet-3091	165	244	.	.	PUNCT
admet-3091	166	1	when	when	SCONJ
admet-3091	166	2	rapid	rapid	ADJ
admet-3091	166	3	hydrophilicity	hydrophilicity	NOUN
admet-3091	166	4	-	-	PUNCT
admet-3091	166	5	mediated	mediate	VERB
admet-3091	166	6	is	be	AUX
admet-3091	166	7	problematic	problematic	ADJ
admet-3091	166	8	:	:	PUNCT
admet-3091	166	9	modify	modify	VERB
admet-3091	166	10	with	with	ADP
admet-3091	166	11	hydrophobic	hydrophobic	ADJ
admet-3091	166	12	moiety	moiety	NOUN
admet-3091	166	13	,	,	PUNCT
admet-3091	166	14	cyclodextrin	cyclodextrin	NOUN
admet-3091	166	15	complexation	complexation	NOUN
admet-3091	166	16	,	,	PUNCT
admet-3091	166	17	or	or	CCONJ
admet-3091	166	18	chitosan	chitosan	NOUN
admet-3091	166	19	coating	coating	NOUN
admet-3091	166	20	drug	drug	NOUN
admet-3091	166	21	loading	loading	NOUN
admet-3091	166	22	higher	high	ADJ
admet-3091	166	23	drug	drug	NOUN
admet-3091	166	24	loading	loading	NOUN
admet-3091	166	25	correlates	correlate	VERB
admet-3091	166	26	with	with	ADP
admet-3091	166	27	faster	fast	ADJ
admet-3091	166	28	sustained	sustained	ADJ
admet-3091	166	29	release	release	NOUN
admet-3091	166	30	–	–	PUNCT
admet-3091	166	31	low	low	ADJ
admet-3091	166	32	drug	drug	NOUN
admet-3091	166	33	loading	loading	NOUN
admet-3091	166	34	risks	risk	NOUN
admet-3091	166	35	premature	premature	ADJ
admet-3091	166	36	release	release	NOUN
admet-3091	166	37	high	high	ADJ
admet-3091	166	38	:	:	PUNCT
admet-3091	166	39	formation	formation	NOUN
admet-3091	166	40	of	of	ADP
admet-3091	166	41	interconnected	interconnected	ADJ
admet-3091	166	42	pore	pore	ADJ
admet-3091	166	43	network	network	NOUN
admet-3091	166	44	–	–	PUNCT
admet-3091	166	45	low	low	ADJ
admet-3091	166	46	:	:	PUNCT
admet-3091	166	47	surface	surface	NOUN
admet-3091	166	48	adsorption	adsorption	NOUN
admet-3091	166	49	must	must	AUX
admet-3091	166	50	be	be	AUX
admet-3091	166	51	optimized	optimize	VERB
admet-3091	166	52	to	to	PART
admet-3091	166	53	balance	balance	VERB
admet-3091	166	54	burst	burst	ADJ
admet-3091	166	55	release	release	NOUN
admet-3091	166	56	and	and	CCONJ
admet-3091	166	57	accelerated	accelerate	VERB
admet-3091	166	58	sustained	sustained	ADJ
admet-3091	166	59	release	release	NOUN
admet-3091	166	60	.	.	PUNCT
admet-3091	167	1	can	can	AUX
admet-3091	167	2	use	use	VERB
admet-3091	167	3	chitosan	chitosan	NOUN
admet-3091	167	4	coating	coating	NOUN
admet-3091	167	5	to	to	PART
admet-3091	167	6	prevent	prevent	VERB
admet-3091	167	7	burst	burst	ADJ
admet-3091	167	8	release	release	NOUN
admet-3091	167	9	plga	plga	NOUN
admet-3091	167	10	concentration	concentration	NOUN
admet-3091	167	11	higher	high	ADJ
admet-3091	167	12	concentration	concentration	NOUN
admet-3091	167	13	correlates	correlate	VERB
admet-3091	167	14	with	with	ADP
admet-3091	167	15	slower	slow	ADJ
admet-3091	167	16	release	release	NOUN
admet-3091	167	17	denser	dense	ADJ
admet-3091	167	18	matrix	matrix	NOUN
admet-3091	167	19	and	and	CCONJ
admet-3091	167	20	limited	limited	ADJ
admet-3091	167	21	interconnectivity	interconnectivity	NOUN
admet-3091	167	22	must	must	AUX
admet-3091	167	23	be	be	AUX
admet-3091	167	24	balanced	balance	VERB
admet-3091	167	25	to	to	PART
admet-3091	167	26	prevent	prevent	VERB
admet-3091	167	27	limited	limited	ADJ
admet-3091	167	28	drug	drug	NOUN
admet-3091	167	29	loading	loading	NOUN
admet-3091	167	30	–	–	PUNCT
admet-3091	167	31	can	can	AUX
admet-3091	167	32	use	use	VERB
admet-3091	167	33	peg	peg	NOUN
admet-3091	167	34	and	and	CCONJ
admet-3091	167	35	mct	mct	PROPN
admet-3091	167	36	to	to	PART
admet-3091	167	37	enhance	enhance	VERB
admet-3091	167	38	interconnectivity	interconnectivity	NOUN
admet-3091	167	39	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	167	40	m.	m.	PROPN
admet-3091	167	41	eshaghi	eshaghi	PROPN
admet-3091	167	42	et	et	PROPN
admet-3091	167	43	al	al	PROPN
admet-3091	167	44	.	.	PROPN
admet-3091	167	45	admet	admet	PROPN
admet-3091	167	46	&	&	CCONJ
admet-3091	167	47	dmpk	dmpk	PROPN
admet-3091	167	48	00(0	00(0	PROPN
admet-3091	167	49	)	)	PUNCT
admet-3091	167	50	(	(	PUNCT
admet-3091	167	51	2025	2025	NUM
admet-3091	167	52	)	)	PUNCT
admet-3091	167	53	3091	3091	NUM
admet-3091	167	54	8	8	NUM
admet-3091	167	55	release	release	NOUN
admet-3091	167	56	mechanisms	mechanism	NOUN
admet-3091	167	57	from	from	ADP
admet-3091	167	58	plga	plga	NOUN
admet-3091	167	59	systems	system	NOUN
admet-3091	167	60	plga	plga	NOUN
admet-3091	167	61	-	-	PUNCT
admet-3091	167	62	based	base	VERB
admet-3091	167	63	peptide	peptide	NOUN
admet-3091	167	64	delivery	delivery	NOUN
admet-3091	167	65	systems	system	NOUN
admet-3091	167	66	typically	typically	ADV
admet-3091	167	67	exhibit	exhibit	VERB
admet-3091	167	68	a	a	DET
admet-3091	167	69	triphasic	triphasic	ADJ
admet-3091	167	70	release	release	NOUN
admet-3091	167	71	profile	profile	NOUN
admet-3091	167	72	,	,	PUNCT
admet-3091	167	73	comprising	comprise	VERB
admet-3091	167	74	an	an	DET
admet-3091	167	75	initial	initial	ADJ
admet-3091	167	76	burst	burst	NOUN
admet-3091	167	77	,	,	PUNCT
admet-3091	167	78	a	a	DET
admet-3091	167	79	lag	lag	NOUN
admet-3091	167	80	phase	phase	NOUN
admet-3091	167	81	,	,	PUNCT
admet-3091	167	82	and	and	CCONJ
admet-3091	167	83	a	a	DET
admet-3091	167	84	sustained	sustain	VERB
admet-3091	167	85	release	release	NOUN
admet-3091	167	86	phase	phase	NOUN
admet-3091	167	87	[	[	X
admet-3091	167	88	2,18	2,18	X
admet-3091	167	89	]	]	X
admet-3091	167	90	.	.	PUNCT
admet-3091	168	1	this	this	DET
admet-3091	168	2	pattern	pattern	NOUN
admet-3091	168	3	reflects	reflect	VERB
admet-3091	168	4	the	the	DET
admet-3091	168	5	complex	complex	ADJ
admet-3091	168	6	interplay	interplay	NOUN
admet-3091	168	7	of	of	ADP
admet-3091	168	8	diffusion	diffusion	NOUN
admet-3091	168	9	and	and	CCONJ
admet-3091	168	10	degradation	degradation	NOUN
admet-3091	168	11	mechanisms	mechanism	NOUN
admet-3091	168	12	operating	operate	VERB
admet-3091	168	13	at	at	ADP
admet-3091	168	14	different	different	ADJ
admet-3091	168	15	stages	stage	NOUN
admet-3091	168	16	of	of	ADP
admet-3091	168	17	peptide	peptide	ADJ
admet-3091	168	18	release	release	NOUN
admet-3091	168	19	[	[	X
admet-3091	168	20	17,31	17,31	NUM
admet-3091	168	21	]	]	PUNCT
admet-3091	168	22	.	.	PUNCT
admet-3091	169	1	phase	phase	NOUN
admet-3091	169	2	i	i	PRON
admet-3091	169	3	:	:	PUNCT
admet-3091	169	4	an	an	DET
admet-3091	169	5	initial	initial	ADJ
admet-3091	169	6	burst	burst	NOUN
admet-3091	169	7	of	of	ADP
admet-3091	169	8	release	release	NOUN
admet-3091	169	9	occurs	occur	VERB
admet-3091	169	10	within	within	ADP
admet-3091	169	11	the	the	DET
admet-3091	169	12	first	first	ADJ
admet-3091	169	13	24	24	NUM
admet-3091	169	14	to	to	ADP
admet-3091	169	15	48	48	NUM
admet-3091	169	16	hours	hour	NOUN
admet-3091	169	17	and	and	CCONJ
admet-3091	169	18	accounts	account	VERB
admet-3091	169	19	for	for	ADP
admet-3091	169	20	10	10	NUM
admet-3091	169	21	to	to	PART
admet-3091	169	22	45	45	NUM
admet-3091	169	23	%	%	NOUN
admet-3091	169	24	of	of	ADP
admet-3091	169	25	total	total	ADJ
admet-3091	169	26	peptide	peptide	NOUN
admet-3091	169	27	release	release	NOUN
admet-3091	169	28	[	[	X
admet-3091	169	29	25	25	NUM
admet-3091	169	30	]	]	PUNCT
admet-3091	169	31	.	.	PUNCT
admet-3091	170	1	this	this	DET
admet-3091	170	2	phase	phase	NOUN
admet-3091	170	3	primarily	primarily	ADV
admet-3091	170	4	results	result	VERB
admet-3091	170	5	from	from	ADP
admet-3091	170	6	surface	surface	NOUN
admet-3091	170	7	-	-	PUNCT
admet-3091	170	8	associated	associate	VERB
admet-3091	170	9	or	or	CCONJ
admet-3091	170	10	weakly	weakly	ADV
admet-3091	170	11	bound	bind	VERB
admet-3091	170	12	peptides	peptide	NOUN
admet-3091	170	13	that	that	PRON
admet-3091	170	14	readily	readily	ADV
admet-3091	170	15	diffuse	diffuse	VERB
admet-3091	170	16	into	into	ADP
admet-3091	170	17	the	the	DET
admet-3091	170	18	release	release	NOUN
admet-3091	170	19	medium	medium	NOUN
admet-3091	170	20	[	[	X
admet-3091	170	21	18,31	18,31	NUM
admet-3091	170	22	]	]	PUNCT
admet-3091	170	23	.	.	PUNCT
admet-3091	171	1	the	the	DET
admet-3091	171	2	magnitude	magnitude	NOUN
admet-3091	171	3	of	of	ADP
admet-3091	171	4	burst	burst	ADJ
admet-3091	171	5	release	release	NOUN
admet-3091	171	6	primarily	primarily	ADV
admet-3091	171	7	depends	depend	VERB
admet-3091	171	8	on	on	ADP
admet-3091	171	9	particle	particle	NOUN
admet-3091	171	10	size	size	NOUN
admet-3091	171	11	,	,	PUNCT
admet-3091	171	12	peptide	peptide	NOUN
admet-3091	171	13	loading	loading	NOUN
admet-3091	171	14	,	,	PUNCT
admet-3091	171	15	and	and	CCONJ
admet-3091	171	16	surface	surface	NOUN
admet-3091	171	17	morphology	morphology	NOUN
admet-3091	171	18	[	[	X
admet-3091	171	19	19,45	19,45	NUM
admet-3091	171	20	]	]	PUNCT
admet-3091	171	21	.	.	PUNCT
admet-3091	172	1	phase	phase	PROPN
admet-3091	172	2	ii	ii	PROPN
admet-3091	172	3	:	:	PUNCT
admet-3091	172	4	lag	lag	NOUN
admet-3091	172	5	phase	phase	NOUN
admet-3091	172	6	represents	represent	VERB
admet-3091	172	7	a	a	DET
admet-3091	172	8	period	period	NOUN
admet-3091	172	9	of	of	ADP
admet-3091	172	10	slow	slow	ADJ
admet-3091	172	11	,	,	PUNCT
admet-3091	172	12	diffusion	diffusion	NOUN
admet-3091	172	13	-	-	PUNCT
admet-3091	172	14	controlled	control	VERB
admet-3091	172	15	release	release	NOUN
admet-3091	172	16	lasting	last	VERB
admet-3091	172	17	days	day	NOUN
admet-3091	172	18	to	to	ADP
admet-3091	172	19	weeks	week	NOUN
admet-3091	172	20	[	[	X
admet-3091	172	21	25,31	25,31	NUM
admet-3091	172	22	]	]	X
admet-3091	172	23	.	.	PUNCT
admet-3091	173	1	during	during	ADP
admet-3091	173	2	this	this	DET
admet-3091	173	3	phase	phase	NOUN
admet-3091	173	4	,	,	PUNCT
admet-3091	173	5	peptide	peptide	NOUN
admet-3091	173	6	diffusion	diffusion	NOUN
admet-3091	173	7	through	through	ADP
admet-3091	173	8	the	the	DET
admet-3091	173	9	intact	intact	ADJ
admet-3091	173	10	polymer	polymer	NOUN
admet-3091	173	11	matrix	matrix	NOUN
admet-3091	173	12	is	be	AUX
admet-3091	173	13	limited	limit	VERB
admet-3091	173	14	,	,	PUNCT
admet-3091	173	15	resulting	result	VERB
admet-3091	173	16	in	in	ADP
admet-3091	173	17	minimal	minimal	ADJ
admet-3091	173	18	peptide	peptide	NOUN
admet-3091	173	19	release	release	NOUN
admet-3091	173	20	[	[	X
admet-3091	173	21	18	18	NUM
admet-3091	173	22	]	]	PUNCT
admet-3091	173	23	.	.	PUNCT
admet-3091	174	1	phase	phase	NOUN
admet-3091	174	2	iii	iii	NOUN
admet-3091	174	3	:	:	PUNCT
admet-3091	174	4	erosion	erosion	NOUN
admet-3091	174	5	-	-	PUNCT
admet-3091	174	6	driven	drive	VERB
admet-3091	174	7	release	release	NOUN
admet-3091	174	8	begins	begin	VERB
admet-3091	174	9	as	as	SCONJ
admet-3091	174	10	polymer	polymer	NOUN
admet-3091	174	11	degradation	degradation	NOUN
admet-3091	174	12	accelerates	accelerate	VERB
admet-3091	174	13	,	,	PUNCT
admet-3091	174	14	creating	create	VERB
admet-3091	174	15	pores	pore	NOUN
admet-3091	174	16	and	and	CCONJ
admet-3091	174	17	channels	channel	NOUN
admet-3091	174	18	that	that	PRON
admet-3091	174	19	facilitate	facilitate	VERB
admet-3091	174	20	sustained	sustained	ADJ
admet-3091	174	21	peptide	peptide	NOUN
admet-3091	174	22	release	release	NOUN
admet-3091	174	23	[	[	X
admet-3091	174	24	31	31	NUM
admet-3091	174	25	]	]	PUNCT
admet-3091	174	26	.	.	PUNCT
admet-3091	175	1	this	this	DET
admet-3091	175	2	phase	phase	NOUN
admet-3091	175	3	typically	typically	ADV
admet-3091	175	4	exhibits	exhibit	VERB
admet-3091	175	5	zero	zero	NUM
admet-3091	175	6	-	-	PUNCT
admet-3091	175	7	order	order	NOUN
admet-3091	175	8	kinetics	kinetic	NOUN
admet-3091	175	9	and	and	CCONJ
admet-3091	175	10	can	can	AUX
admet-3091	175	11	last	last	VERB
admet-3091	175	12	for	for	ADP
admet-3091	175	13	weeks	week	NOUN
admet-3091	175	14	to	to	ADP
admet-3091	175	15	months	month	NOUN
admet-3091	175	16	,	,	PUNCT
admet-3091	175	17	depending	depend	VERB
admet-3091	175	18	on	on	ADP
admet-3091	175	19	polymer	polymer	NOUN
admet-3091	175	20	properties	property	NOUN
admet-3091	175	21	[	[	X
admet-3091	175	22	2,18	2,18	X
admet-3091	175	23	]	]	X
admet-3091	175	24	.	.	PUNCT
admet-3091	176	1	smaller	small	ADJ
admet-3091	176	2	plga	plga	NOUN
admet-3091	176	3	particles	particle	NOUN
admet-3091	176	4	or	or	CCONJ
admet-3091	176	5	formulations	formulation	NOUN
admet-3091	176	6	with	with	ADP
admet-3091	176	7	rapid	rapid	ADJ
admet-3091	176	8	degradation	degradation	NOUN
admet-3091	176	9	often	often	ADV
admet-3091	176	10	exhibit	exhibit	VERB
admet-3091	176	11	simplified	simplify	VERB
admet-3091	176	12	biphasic	biphasic	ADJ
admet-3091	176	13	release	release	NOUN
admet-3091	176	14	patterns	pattern	NOUN
admet-3091	176	15	,	,	PUNCT
admet-3091	176	16	consisting	consist	VERB
admet-3091	176	17	of	of	ADP
admet-3091	176	18	an	an	DET
admet-3091	176	19	initial	initial	ADJ
admet-3091	176	20	burst	burst	NOUN
admet-3091	176	21	followed	follow	VERB
admet-3091	176	22	by	by	ADP
admet-3091	176	23	sustained	sustained	ADJ
admet-3091	176	24	release	release	NOUN
admet-3091	176	25	without	without	ADP
admet-3091	176	26	a	a	DET
admet-3091	176	27	distinct	distinct	ADJ
admet-3091	176	28	lag	lag	NOUN
admet-3091	176	29	phase	phase	NOUN
admet-3091	176	30	.	.	PUNCT
admet-3091	177	1	this	this	PRON
admet-3091	177	2	occurs	occur	VERB
admet-3091	177	3	when	when	SCONJ
admet-3091	177	4	particle	particle	NOUN
admet-3091	177	5	degradation	degradation	NOUN
admet-3091	177	6	proceeds	proceed	VERB
admet-3091	177	7	faster	fast	ADV
admet-3091	177	8	than	than	ADP
admet-3091	177	9	the	the	DET
admet-3091	177	10	time	time	NOUN
admet-3091	177	11	scale	scale	NOUN
admet-3091	177	12	required	require	VERB
admet-3091	177	13	for	for	ADP
admet-3091	177	14	complete	complete	ADJ
admet-3091	177	15	drug	drug	NOUN
admet-3091	177	16	depletion	depletion	NOUN
admet-3091	178	1	[	[	X
admet-3091	178	2	31,46	31,46	NOUN
admet-3091	178	3	]	]	PUNCT
admet-3091	178	4	.	.	PUNCT
admet-3091	179	1	formulation	formulation	NOUN
admet-3091	179	2	strategies	strategy	NOUN
admet-3091	179	3	for	for	ADP
admet-3091	179	4	controlled	control	VERB
admet-3091	179	5	release	release	NOUN
admet-3091	179	6	single	single	ADJ
admet-3091	179	7	oil	oil	NOUN
admet-3091	179	8	-	-	PUNCT
admet-3091	179	9	in	in	ADP
admet-3091	179	10	-	-	PUNCT
admet-3091	179	11	water	water	NOUN
admet-3091	179	12	emulsion	emulsion	NOUN
admet-3091	179	13	and	and	CCONJ
admet-3091	179	14	double	double	ADJ
admet-3091	179	15	water	water	NOUN
admet-3091	179	16	-	-	PUNCT
admet-3091	179	17	in	in	ADP
admet-3091	179	18	-	-	PUNCT
admet-3091	179	19	oil	oil	NOUN
admet-3091	179	20	-	-	PUNCT
admet-3091	179	21	in	in	ADP
admet-3091	179	22	-	-	PUNCT
admet-3091	179	23	water	water	NOUN
admet-3091	179	24	emulsion	emulsion	NOUN
admet-3091	179	25	emulsion	emulsion	NOUN
admet-3091	179	26	-	-	PUNCT
admet-3091	179	27	based	base	VERB
admet-3091	179	28	methods	method	NOUN
admet-3091	179	29	are	be	AUX
admet-3091	179	30	among	among	ADP
admet-3091	179	31	the	the	DET
admet-3091	179	32	most	most	ADV
admet-3091	179	33	widely	widely	ADV
admet-3091	179	34	used	use	VERB
admet-3091	179	35	techniques	technique	NOUN
admet-3091	179	36	for	for	ADP
admet-3091	179	37	the	the	DET
admet-3091	179	38	synthesis	synthesis	NOUN
admet-3091	179	39	of	of	ADP
admet-3091	179	40	nanoparticles	nanoparticle	NOUN
admet-3091	179	41	and	and	CCONJ
admet-3091	179	42	microparticles	microparticle	NOUN
admet-3091	179	43	,	,	PUNCT
admet-3091	179	44	as	as	SCONJ
admet-3091	179	45	they	they	PRON
admet-3091	179	46	are	be	AUX
admet-3091	179	47	compatible	compatible	ADJ
admet-3091	179	48	with	with	ADP
admet-3091	179	49	a	a	DET
admet-3091	179	50	broad	broad	ADJ
admet-3091	179	51	range	range	NOUN
admet-3091	179	52	of	of	ADP
admet-3091	179	53	drugs	drug	NOUN
admet-3091	179	54	with	with	ADP
admet-3091	179	55	diverse	diverse	ADJ
admet-3091	179	56	solubility	solubility	NOUN
admet-3091	179	57	profiles	profile	NOUN
admet-3091	179	58	.	.	PUNCT
admet-3091	180	1	the	the	DET
admet-3091	180	2	singleemulsion	singleemulsion	NOUN
admet-3091	180	3	technique	technique	NOUN
admet-3091	180	4	(	(	PUNCT
admet-3091	180	5	oil	oil	NOUN
admet-3091	180	6	-	-	PUNCT
admet-3091	180	7	in	in	ADP
admet-3091	180	8	-	-	PUNCT
admet-3091	180	9	water	water	NOUN
admet-3091	180	10	,	,	PUNCT
admet-3091	180	11	o	o	NOUN
admet-3091	180	12	/	/	SYM
admet-3091	180	13	w	w	NOUN
admet-3091	180	14	)	)	PUNCT
admet-3091	180	15	is	be	AUX
admet-3091	180	16	particularly	particularly	ADV
admet-3091	180	17	well	well	ADV
admet-3091	180	18	suited	suited	ADJ
admet-3091	180	19	to	to	ADP
admet-3091	180	20	encapsulating	encapsulate	VERB
admet-3091	180	21	hydrophobic	hydrophobic	NOUN
admet-3091	180	22	drugs	drug	NOUN
admet-3091	180	23	.	.	PUNCT
admet-3091	181	1	in	in	ADP
admet-3091	181	2	this	this	DET
admet-3091	181	3	approach	approach	NOUN
admet-3091	181	4	,	,	PUNCT
admet-3091	181	5	plga	plga	NOUN
admet-3091	181	6	and	and	CCONJ
admet-3091	181	7	the	the	DET
admet-3091	181	8	drug	drug	NOUN
admet-3091	181	9	are	be	AUX
admet-3091	181	10	first	first	ADV
admet-3091	181	11	dissolved	dissolve	VERB
admet-3091	181	12	in	in	ADP
admet-3091	181	13	a	a	DET
admet-3091	181	14	small	small	ADJ
admet-3091	181	15	volume	volume	NOUN
admet-3091	181	16	of	of	ADP
admet-3091	181	17	a	a	DET
admet-3091	181	18	volatile	volatile	ADJ
admet-3091	181	19	organic	organic	ADJ
admet-3091	181	20	solvent	solvent	NOUN
admet-3091	181	21	.	.	PUNCT
admet-3091	182	1	this	this	DET
admet-3091	182	2	organic	organic	ADJ
admet-3091	182	3	phase	phase	NOUN
admet-3091	182	4	is	be	AUX
admet-3091	182	5	then	then	ADV
admet-3091	182	6	added	add	VERB
admet-3091	182	7	dropwise	dropwise	NOUN
admet-3091	182	8	to	to	ADP
admet-3091	182	9	an	an	DET
admet-3091	182	10	aqueous	aqueous	ADJ
admet-3091	182	11	phase	phase	NOUN
admet-3091	182	12	containing	contain	VERB
admet-3091	182	13	a	a	DET
admet-3091	182	14	stabilizer	stabilizer	NOUN
admet-3091	182	15	,	,	PUNCT
admet-3091	182	16	typically	typically	ADV
admet-3091	182	17	polyvinyl	polyvinyl	NOUN
admet-3091	182	18	alcohol	alcohol	NOUN
admet-3091	182	19	(	(	PUNCT
admet-3091	182	20	pva	pva	NOUN
admet-3091	182	21	)	)	PUNCT
admet-3091	182	22	.	.	PUNCT
admet-3091	183	1	the	the	DET
admet-3091	183	2	resulting	result	VERB
admet-3091	183	3	mixture	mixture	NOUN
admet-3091	183	4	is	be	AUX
admet-3091	183	5	homogenized	homogenize	VERB
admet-3091	183	6	by	by	ADP
admet-3091	183	7	sonication	sonication	NOUN
admet-3091	183	8	and	and	CCONJ
admet-3091	183	9	stirred	stir	VERB
admet-3091	183	10	for	for	ADP
admet-3091	183	11	a	a	DET
admet-3091	183	12	defined	define	VERB
admet-3091	183	13	period	period	NOUN
admet-3091	183	14	to	to	PART
admet-3091	183	15	ensure	ensure	VERB
admet-3091	183	16	complete	complete	ADJ
admet-3091	183	17	evaporation	evaporation	NOUN
admet-3091	183	18	of	of	ADP
admet-3091	183	19	the	the	DET
admet-3091	183	20	organic	organic	ADJ
admet-3091	183	21	solvent	solvent	NOUN
admet-3091	183	22	,	,	PUNCT
admet-3091	183	23	thereby	thereby	ADV
admet-3091	183	24	forming	form	VERB
admet-3091	183	25	stable	stable	ADJ
admet-3091	183	26	particles	particle	NOUN
admet-3091	183	27	.	.	PUNCT
admet-3091	184	1	the	the	DET
admet-3091	184	2	double	double	ADJ
admet-3091	184	3	emulsion	emulsion	NOUN
admet-3091	184	4	method	method	NOUN
admet-3091	184	5	is	be	AUX
admet-3091	184	6	employed	employ	VERB
admet-3091	184	7	when	when	SCONJ
admet-3091	184	8	the	the	DET
admet-3091	184	9	active	active	ADJ
admet-3091	184	10	agent	agent	NOUN
admet-3091	184	11	to	to	PART
admet-3091	184	12	be	be	AUX
admet-3091	184	13	encapsulated	encapsulate	VERB
admet-3091	184	14	is	be	AUX
admet-3091	184	15	hydrophilic	hydrophilic	ADJ
admet-3091	184	16	.	.	PUNCT
admet-3091	185	1	this	this	DET
admet-3091	185	2	technique	technique	NOUN
admet-3091	185	3	is	be	AUX
admet-3091	185	4	commonly	commonly	ADV
admet-3091	185	5	used	use	VERB
admet-3091	185	6	for	for	ADP
admet-3091	185	7	the	the	DET
admet-3091	185	8	encapsulation	encapsulation	NOUN
admet-3091	185	9	of	of	ADP
admet-3091	185	10	proteins	protein	NOUN
admet-3091	185	11	,	,	PUNCT
admet-3091	185	12	peptides	peptide	NOUN
admet-3091	185	13	,	,	PUNCT
admet-3091	185	14	and	and	CCONJ
admet-3091	185	15	various	various	ADJ
admet-3091	185	16	hydrophilic	hydrophilic	ADJ
admet-3091	185	17	drugs	drug	NOUN
admet-3091	185	18	.	.	PUNCT
admet-3091	186	1	in	in	ADP
admet-3091	186	2	this	this	DET
admet-3091	186	3	method	method	NOUN
admet-3091	186	4	,	,	PUNCT
admet-3091	186	5	the	the	DET
admet-3091	186	6	active	active	ADJ
admet-3091	186	7	compound	compound	NOUN
admet-3091	186	8	is	be	AUX
admet-3091	186	9	first	first	ADV
admet-3091	186	10	dissolved	dissolve	VERB
admet-3091	186	11	in	in	ADP
admet-3091	186	12	an	an	DET
admet-3091	186	13	aqueous	aqueous	ADJ
admet-3091	186	14	phase	phase	NOUN
admet-3091	186	15	,	,	PUNCT
admet-3091	186	16	which	which	PRON
admet-3091	186	17	is	be	AUX
admet-3091	186	18	then	then	ADV
admet-3091	186	19	added	add	VERB
admet-3091	186	20	to	to	ADP
admet-3091	186	21	a	a	DET
admet-3091	186	22	plga	plga	NOUN
admet-3091	186	23	solution	solution	NOUN
admet-3091	186	24	in	in	ADP
admet-3091	186	25	an	an	DET
admet-3091	186	26	organic	organic	ADJ
admet-3091	186	27	solvent	solvent	NOUN
admet-3091	186	28	,	,	PUNCT
admet-3091	186	29	forming	form	VERB
admet-3091	186	30	a	a	DET
admet-3091	186	31	primary	primary	ADJ
admet-3091	186	32	water	water	NOUN
admet-3091	186	33	-	-	PUNCT
admet-3091	186	34	in	in	ADP
admet-3091	186	35	-	-	PUNCT
admet-3091	186	36	oil	oil	NOUN
admet-3091	186	37	(	(	PUNCT
admet-3091	186	38	w/o	w/o	PROPN
admet-3091	186	39	)	)	PUNCT
admet-3091	186	40	emulsion	emulsion	NOUN
admet-3091	186	41	.	.	PUNCT
admet-3091	187	1	this	this	DET
admet-3091	187	2	primary	primary	ADJ
admet-3091	187	3	emulsion	emulsion	NOUN
admet-3091	187	4	is	be	AUX
admet-3091	187	5	subsequently	subsequently	ADV
admet-3091	187	6	added	add	VERB
admet-3091	187	7	to	to	ADP
admet-3091	187	8	a	a	DET
admet-3091	187	9	second	second	ADJ
admet-3091	187	10	aqueous	aqueous	ADJ
admet-3091	187	11	phase	phase	NOUN
admet-3091	187	12	containing	contain	VERB
admet-3091	187	13	a	a	DET
admet-3091	187	14	stabilizer	stabilizer	NOUN
admet-3091	187	15	,	,	PUNCT
admet-3091	187	16	and	and	CCONJ
admet-3091	187	17	the	the	DET
admet-3091	187	18	mixture	mixture	NOUN
admet-3091	187	19	is	be	AUX
admet-3091	187	20	homogenized	homogenize	VERB
admet-3091	187	21	to	to	PART
admet-3091	187	22	form	form	VERB
admet-3091	187	23	a	a	DET
admet-3091	187	24	water	water	NOUN
admet-3091	187	25	-	-	PUNCT
admet-3091	187	26	in	in	ADP
admet-3091	187	27	-	-	PUNCT
admet-3091	187	28	oil	oil	NOUN
admet-3091	187	29	-	-	PUNCT
admet-3091	187	30	in	in	ADP
admet-3091	187	31	-	-	PUNCT
admet-3091	187	32	water	water	NOUN
admet-3091	187	33	(	(	PUNCT
admet-3091	187	34	w/o	w/o	PROPN
admet-3091	187	35	/	/	SYM
admet-3091	187	36	w	w	NOUN
admet-3091	187	37	)	)	PUNCT
admet-3091	187	38	emulsion	emulsion	NOUN
admet-3091	187	39	.	.	PUNCT
admet-3091	188	1	the	the	DET
admet-3091	188	2	organic	organic	ADJ
admet-3091	188	3	solvent	solvent	NOUN
admet-3091	188	4	is	be	AUX
admet-3091	188	5	then	then	ADV
admet-3091	188	6	evaporated	evaporate	VERB
admet-3091	188	7	under	under	ADP
admet-3091	188	8	stirring	stirring	NOUN
admet-3091	188	9	,	,	PUNCT
admet-3091	188	10	resulting	result	VERB
admet-3091	188	11	in	in	ADP
admet-3091	188	12	the	the	DET
admet-3091	188	13	formation	formation	NOUN
admet-3091	188	14	of	of	ADP
admet-3091	188	15	hardened	hardened	ADJ
admet-3091	188	16	particles	particle	NOUN
admet-3091	188	17	.	.	PUNCT
admet-3091	189	1	the	the	DET
admet-3091	189	2	product	product	NOUN
admet-3091	189	3	is	be	AUX
admet-3091	189	4	collected	collect	VERB
admet-3091	189	5	by	by	ADP
admet-3091	189	6	centrifugation	centrifugation	NOUN
admet-3091	189	7	or	or	CCONJ
admet-3091	189	8	ultrafiltration	ultrafiltration	NOUN
admet-3091	189	9	and	and	CCONJ
admet-3091	189	10	washed	wash	VERB
admet-3091	189	11	to	to	PART
admet-3091	189	12	remove	remove	VERB
admet-3091	189	13	unreacted	unreacted	ADJ
admet-3091	189	14	components	component	NOUN
admet-3091	189	15	.	.	PUNCT
admet-3091	190	1	finally	finally	ADV
admet-3091	190	2	,	,	PUNCT
admet-3091	190	3	the	the	DET
admet-3091	190	4	particles	particle	NOUN
admet-3091	190	5	are	be	AUX
admet-3091	190	6	dried	dry	VERB
admet-3091	190	7	,	,	PUNCT
admet-3091	190	8	allowing	allow	VERB
admet-3091	190	9	them	they	PRON
admet-3091	190	10	to	to	PART
admet-3091	190	11	remain	remain	VERB
admet-3091	190	12	stable	stable	ADJ
admet-3091	190	13	for	for	ADP
admet-3091	190	14	prolonged	prolonged	ADJ
admet-3091	190	15	periods	period	NOUN
admet-3091	190	16	[	[	X
admet-3091	190	17	7,25,47	7,25,47	NUM
admet-3091	190	18	]	]	SYM
admet-3091	190	19	.	.	PUNCT
admet-3091	191	1	spray	spray	NOUN
admet-3091	191	2	drying	dry	VERB
admet-3091	191	3	this	this	DET
admet-3091	191	4	approach	approach	NOUN
admet-3091	191	5	offers	offer	VERB
admet-3091	191	6	scalable	scalable	ADJ
admet-3091	191	7	,	,	PUNCT
admet-3091	191	8	one	one	NUM
admet-3091	191	9	-	-	PUNCT
admet-3091	191	10	step	step	NOUN
admet-3091	191	11	production	production	NOUN
admet-3091	191	12	with	with	ADP
admet-3091	191	13	precise	precise	ADJ
admet-3091	191	14	control	control	NOUN
admet-3091	191	15	over	over	ADP
admet-3091	191	16	particle	particle	NOUN
admet-3091	191	17	properties	property	NOUN
admet-3091	191	18	.	.	PUNCT
admet-3091	192	1	particles	particle	NOUN
admet-3091	192	2	are	be	AUX
admet-3091	192	3	formed	form	VERB
admet-3091	192	4	by	by	ADP
admet-3091	192	5	atomization	atomization	NOUN
admet-3091	192	6	of	of	ADP
admet-3091	192	7	the	the	DET
admet-3091	192	8	emulsion	emulsion	NOUN
admet-3091	192	9	through	through	ADP
admet-3091	192	10	a	a	DET
admet-3091	192	11	hot	hot	ADJ
admet-3091	192	12	air	air	NOUN
admet-3091	192	13	stream	stream	NOUN
admet-3091	192	14	and	and	CCONJ
admet-3091	192	15	fast	fast	ADJ
admet-3091	192	16	solvent	solvent	ADJ
admet-3091	192	17	evaporation	evaporation	NOUN
admet-3091	192	18	.	.	PUNCT
admet-3091	193	1	poor	poor	ADJ
admet-3091	193	2	solvents	solvent	NOUN
admet-3091	193	3	,	,	PUNCT
admet-3091	193	4	such	such	ADJ
admet-3091	193	5	as	as	ADP
admet-3091	193	6	methanol	methanol	NOUN
admet-3091	193	7	,	,	PUNCT
admet-3091	193	8	promote	promote	VERB
admet-3091	193	9	early	early	ADJ
admet-3091	193	10	plga	plga	NOUN
admet-3091	193	11	shell	shell	NOUN
admet-3091	193	12	formation	formation	NOUN
admet-3091	193	13	but	but	CCONJ
admet-3091	193	14	increase	increase	VERB
admet-3091	193	15	the	the	DET
admet-3091	193	16	risk	risk	NOUN
admet-3091	193	17	of	of	ADP
admet-3091	193	18	surface	surface	NOUN
admet-3091	193	19	drug	drug	NOUN
admet-3091	193	20	migration	migration	NOUN
admet-3091	193	21	,	,	PUNCT
admet-3091	193	22	whereas	whereas	SCONJ
admet-3091	193	23	fast	fast	ADV
admet-3091	193	24	-	-	PUNCT
admet-3091	193	25	evaporating	evaporate	VERB
admet-3091	193	26	solvents	solvent	NOUN
admet-3091	193	27	,	,	PUNCT
admet-3091	193	28	such	such	ADJ
admet-3091	193	29	as	as	ADP
admet-3091	193	30	dichloromethane	dichloromethane	NOUN
admet-3091	193	31	,	,	PUNCT
admet-3091	193	32	limit	limit	VERB
admet-3091	193	33	burst	burst	ADJ
admet-3091	193	34	release	release	NOUN
admet-3091	193	35	to	to	ADP
admet-3091	193	36	15	15	PROPN
admet-3091	193	37	%	%	NOUN
admet-3091	193	38	.	.	PUNCT
admet-3091	194	1	different	different	ADJ
admet-3091	194	2	atomization	atomization	NOUN
admet-3091	194	3	techniques	technique	NOUN
admet-3091	194	4	,	,	PUNCT
admet-3091	194	5	including	include	VERB
admet-3091	194	6	two	two	NUM
admet-3091	194	7	-	-	PUNCT
admet-3091	194	8	fluid	fluid	NOUN
admet-3091	194	9	,	,	PUNCT
admet-3091	194	10	three	three	NUM
admet-3091	194	11	-	-	PUNCT
admet-3091	194	12	fluid	fluid	ADJ
admet-3091	194	13	,	,	PUNCT
admet-3091	194	14	and	and	CCONJ
admet-3091	194	15	ultrasonic	ultrasonic	ADJ
admet-3091	194	16	atomization	atomization	NOUN
admet-3091	194	17	,	,	PUNCT
admet-3091	194	18	have	have	VERB
admet-3091	194	19	limitations	limitation	NOUN
admet-3091	194	20	in	in	ADP
admet-3091	194	21	scalability	scalability	NOUN
admet-3091	194	22	,	,	PUNCT
admet-3091	194	23	size	size	NOUN
admet-3091	194	24	control	control	NOUN
admet-3091	194	25	,	,	PUNCT
admet-3091	194	26	and	and	CCONJ
admet-3091	194	27	peptide	peptide	NOUN
admet-3091	194	28	destabilization	destabilization	NOUN
admet-3091	194	29	,	,	PUNCT
admet-3091	194	30	respectively	respectively	ADV
admet-3091	194	31	[	[	X
admet-3091	194	32	25,48	25,48	NOUN
admet-3091	194	33	]	]	X
admet-3091	194	34	.	.	PUNCT
admet-3091	195	1	admet	admet	PROPN
admet-3091	195	2	&	&	CCONJ
admet-3091	195	3	dmpk	dmpk	PROPN
admet-3091	195	4	00(0	00(0	PROPN
admet-3091	195	5	)	)	PUNCT
admet-3091	195	6	(	(	PUNCT
admet-3091	195	7	2025	2025	NUM
admet-3091	195	8	)	)	PUNCT
admet-3091	195	9	3091	3091	NUM
admet-3091	195	10	plga	plga	NOUN
admet-3091	195	11	nanoparticles	nanoparticle	NOUN
admet-3091	195	12	and	and	CCONJ
admet-3091	195	13	microparticles	microparticle	NOUN
admet-3091	195	14	for	for	ADP
admet-3091	195	15	peptide	peptide	ADJ
admet-3091	195	16	delivery	delivery	NOUN
admet-3091	195	17	doi	doi	NOUN
admet-3091	195	18	:	:	PUNCT
admet-3091	195	19	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	195	20	9	9	NUM
admet-3091	195	21	inkjet	inkjet	NOUN
admet-3091	195	22	printing	print	VERB
admet-3091	195	23	the	the	DET
admet-3091	195	24	inkjet	inkjet	NOUN
admet-3091	195	25	printing	printing	NOUN
admet-3091	195	26	technique	technique	NOUN
admet-3091	195	27	is	be	AUX
admet-3091	195	28	another	another	DET
admet-3091	195	29	scalable	scalable	ADJ
admet-3091	195	30	approach	approach	NOUN
admet-3091	195	31	,	,	PUNCT
admet-3091	195	32	owing	owe	VERB
admet-3091	195	33	to	to	ADP
admet-3091	195	34	large	large	ADJ
admet-3091	195	35	-	-	PUNCT
admet-3091	195	36	scale	scale	NOUN
admet-3091	195	37	nozzle	nozzle	NOUN
admet-3091	195	38	arrays	array	VERB
admet-3091	195	39	,	,	PUNCT
admet-3091	195	40	and	and	CCONJ
admet-3091	195	41	provides	provide	VERB
admet-3091	195	42	exceptional	exceptional	ADJ
admet-3091	195	43	control	control	NOUN
admet-3091	195	44	over	over	ADP
admet-3091	195	45	particle	particle	NOUN
admet-3091	195	46	size	size	NOUN
admet-3091	195	47	and	and	CCONJ
admet-3091	195	48	morphology	morphology	NOUN
admet-3091	195	49	.	.	PUNCT
admet-3091	196	1	this	this	DET
admet-3091	196	2	method	method	NOUN
admet-3091	196	3	has	have	AUX
admet-3091	196	4	achieved	achieve	VERB
admet-3091	196	5	54	54	NUM
admet-3091	196	6	and	and	CCONJ
admet-3091	196	7	93	93	NUM
admet-3091	196	8	%	%	NOUN
admet-3091	196	9	encapsulation	encapsulation	NOUN
admet-3091	196	10	efficiency	efficiency	NOUN
admet-3091	196	11	for	for	ADP
admet-3091	196	12	octreotide	octreotide	NOUN
admet-3091	196	13	and	and	CCONJ
admet-3091	196	14	ciclosporin	ciclosporin	NOUN
admet-3091	196	15	a	a	PRON
admet-3091	196	16	,	,	PUNCT
admet-3091	196	17	respectively	respectively	ADV
admet-3091	196	18	,	,	PUNCT
admet-3091	196	19	with	with	ADP
admet-3091	196	20	sustained	sustained	ADJ
admet-3091	196	21	release	release	NOUN
admet-3091	196	22	over	over	ADP
admet-3091	196	23	49	49	NUM
admet-3091	196	24	to	to	PART
admet-3091	196	25	100	100	NUM
admet-3091	196	26	days	day	NOUN
admet-3091	196	27	.	.	PUNCT
admet-3091	197	1	limited	limited	ADJ
admet-3091	197	2	residual	residual	ADJ
admet-3091	197	3	solvent	solvent	NOUN
admet-3091	197	4	in	in	ADP
admet-3091	197	5	the	the	DET
admet-3091	197	6	final	final	ADJ
admet-3091	197	7	product	product	NOUN
admet-3091	197	8	is	be	AUX
admet-3091	197	9	another	another	DET
admet-3091	197	10	advantage	advantage	NOUN
admet-3091	197	11	of	of	ADP
admet-3091	197	12	this	this	DET
admet-3091	197	13	technique	technique	NOUN
admet-3091	197	14	.	.	PUNCT
admet-3091	198	1	several	several	ADJ
admet-3091	198	2	parameters	parameter	NOUN
admet-3091	198	3	of	of	ADP
admet-3091	198	4	the	the	DET
admet-3091	198	5	involved	involved	ADJ
admet-3091	198	6	materials	material	NOUN
admet-3091	198	7	and	and	CCONJ
admet-3091	198	8	printing	printing	NOUN
admet-3091	198	9	equipment	equipment	NOUN
admet-3091	198	10	influence	influence	NOUN
admet-3091	198	11	particle	particle	NOUN
admet-3091	198	12	properties	property	NOUN
admet-3091	198	13	,	,	PUNCT
admet-3091	198	14	and	and	CCONJ
admet-3091	198	15	the	the	DET
admet-3091	198	16	optimization	optimization	NOUN
admet-3091	198	17	process	process	NOUN
admet-3091	198	18	can	can	AUX
admet-3091	198	19	be	be	AUX
admet-3091	198	20	complex	complex	ADJ
admet-3091	198	21	[	[	X
admet-3091	198	22	28	28	NUM
admet-3091	198	23	]	]	PUNCT
admet-3091	198	24	.	.	PUNCT
admet-3091	199	1	precipitation	precipitation	NOUN
admet-3091	199	2	this	this	DET
admet-3091	199	3	simple	simple	ADJ
admet-3091	199	4	and	and	CCONJ
admet-3091	199	5	cost	cost	NOUN
admet-3091	199	6	-	-	PUNCT
admet-3091	199	7	effective	effective	ADJ
admet-3091	199	8	method	method	NOUN
admet-3091	199	9	yields	yield	VERB
admet-3091	199	10	particles	particle	NOUN
admet-3091	199	11	with	with	ADP
admet-3091	199	12	moderate	moderate	ADJ
admet-3091	199	13	encapsulation	encapsulation	NOUN
admet-3091	199	14	efficiency	efficiency	NOUN
admet-3091	199	15	.	.	PUNCT
admet-3091	200	1	particles	particle	NOUN
admet-3091	200	2	are	be	AUX
admet-3091	200	3	formed	form	VERB
admet-3091	200	4	by	by	ADP
admet-3091	200	5	the	the	DET
admet-3091	200	6	gradual	gradual	ADJ
admet-3091	200	7	addition	addition	NOUN
admet-3091	200	8	of	of	ADP
admet-3091	200	9	an	an	DET
admet-3091	200	10	organic	organic	ADJ
admet-3091	200	11	water	water	NOUN
admet-3091	200	12	-	-	PUNCT
admet-3091	200	13	miscible	miscible	NOUN
admet-3091	200	14	solvent	solvent	NOUN
admet-3091	200	15	containing	contain	VERB
admet-3091	200	16	the	the	DET
admet-3091	200	17	polymer	polymer	NOUN
admet-3091	200	18	into	into	ADP
admet-3091	200	19	an	an	DET
admet-3091	200	20	aqueous	aqueous	ADJ
admet-3091	200	21	phase	phase	NOUN
admet-3091	200	22	.	.	PUNCT
admet-3091	201	1	non	non	ADJ
admet-3091	201	2	-	-	ADJ
admet-3091	201	3	aqueous	aqueous	ADJ
admet-3091	201	4	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	201	5	has	have	AUX
admet-3091	201	6	achieved	achieve	VERB
admet-3091	201	7	100	100	NUM
admet-3091	201	8	%	%	NOUN
admet-3091	201	9	encapsulation	encapsulation	NOUN
admet-3091	201	10	efficiency	efficiency	NOUN
admet-3091	201	11	for	for	ADP
admet-3091	201	12	neuropeptides	neuropeptide	NOUN
admet-3091	201	13	while	while	SCONJ
admet-3091	201	14	minimizing	minimize	VERB
admet-3091	201	15	premature	premature	ADJ
admet-3091	201	16	drug	drug	NOUN
admet-3091	201	17	leakage	leakage	NOUN
admet-3091	202	1	[	[	X
admet-3091	202	2	14,49	14,49	NUM
admet-3091	202	3	]	]	X
admet-3091	202	4	.	.	PUNCT
admet-3091	203	1	flash	flash	PROPN
admet-3091	203	2	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	203	3	compared	compare	VERB
admet-3091	203	4	to	to	ADP
admet-3091	203	5	conventional	conventional	ADJ
admet-3091	203	6	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	203	7	,	,	PUNCT
admet-3091	203	8	flash	flash	VERB
admet-3091	203	9	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	203	10	(	(	PUNCT
admet-3091	203	11	fnp	fnp	PROPN
admet-3091	203	12	)	)	PUNCT
admet-3091	203	13	employs	employ	VERB
admet-3091	203	14	turbulent	turbulent	ADJ
admet-3091	203	15	mixing	mixing	NOUN
admet-3091	203	16	in	in	ADP
admet-3091	203	17	confined	confine	VERB
admet-3091	203	18	mixing	mixing	NOUN
admet-3091	203	19	vessels	vessel	NOUN
admet-3091	203	20	within	within	ADP
admet-3091	203	21	milliseconds	millisecond	NOUN
admet-3091	203	22	to	to	PART
admet-3091	203	23	yield	yield	VERB
admet-3091	203	24	highly	highly	ADV
admet-3091	203	25	uniform	uniform	ADJ
admet-3091	203	26	particles	particle	NOUN
admet-3091	203	27	.	.	PUNCT
admet-3091	204	1	this	this	DET
admet-3091	204	2	advanced	advanced	ADJ
admet-3091	204	3	technique	technique	NOUN
admet-3091	204	4	enables	enable	VERB
admet-3091	204	5	high	high	ADJ
admet-3091	204	6	loading	loading	NOUN
admet-3091	204	7	(	(	PUNCT
admet-3091	204	8	up	up	ADP
admet-3091	204	9	to	to	PART
admet-3091	204	10	90	90	NUM
admet-3091	204	11	wt.%	wt.%	ADJ
admet-3091	204	12	)	)	PUNCT
admet-3091	204	13	and	and	CCONJ
admet-3091	204	14	encapsulation	encapsulation	NOUN
admet-3091	204	15	efficiency	efficiency	NOUN
admet-3091	204	16	(	(	PUNCT
admet-3091	204	17	>	>	SYM
admet-3091	204	18	90	90	NUM
admet-3091	204	19	%	%	NOUN
admet-3091	204	20	)	)	PUNCT
admet-3091	204	21	while	while	SCONJ
admet-3091	204	22	maintaining	maintain	VERB
admet-3091	204	23	particle	particle	NOUN
admet-3091	204	24	stability	stability	NOUN
admet-3091	204	25	.	.	PUNCT
admet-3091	205	1	moreover	moreover	ADV
admet-3091	205	2	,	,	PUNCT
admet-3091	205	3	fnp	fnp	PROPN
admet-3091	205	4	minimizes	minimize	VERB
admet-3091	205	5	peptide	peptide	NOUN
admet-3091	205	6	exposure	exposure	NOUN
admet-3091	205	7	to	to	ADP
admet-3091	205	8	denaturing	denature	VERB
admet-3091	205	9	interfaces	interface	NOUN
admet-3091	205	10	[	[	X
admet-3091	205	11	31	31	NUM
admet-3091	205	12	]	]	PUNCT
admet-3091	205	13	.	.	PUNCT
admet-3091	206	1	microfluidic	microfluidic	ADJ
admet-3091	206	2	methods	method	NOUN
admet-3091	206	3	using	use	VERB
admet-3091	206	4	a	a	DET
admet-3091	206	5	microchannel	microchannel	NOUN
admet-3091	206	6	-	-	PUNCT
admet-3091	206	7	equipped	equip	VERB
admet-3091	206	8	chip	chip	NOUN
admet-3091	206	9	,	,	PUNCT
admet-3091	206	10	this	this	DET
admet-3091	206	11	highly	highly	ADV
admet-3091	206	12	reproducible	reproducible	ADJ
admet-3091	206	13	approach	approach	NOUN
admet-3091	206	14	produces	produce	VERB
admet-3091	206	15	pico	pico	NOUN
admet-3091	206	16	-	-	PUNCT
admet-3091	206	17	scale	scale	NOUN
admet-3091	206	18	emulsion	emulsion	NOUN
admet-3091	206	19	droplets	droplet	NOUN
admet-3091	206	20	to	to	PART
admet-3091	206	21	provide	provide	VERB
admet-3091	206	22	precise	precise	ADJ
admet-3091	206	23	control	control	NOUN
admet-3091	206	24	over	over	ADP
admet-3091	206	25	particle	particle	NOUN
admet-3091	206	26	size	size	NOUN
admet-3091	206	27	and	and	CCONJ
admet-3091	206	28	polydispersity	polydispersity	NOUN
admet-3091	206	29	,	,	PUNCT
admet-3091	206	30	resulting	result	VERB
admet-3091	206	31	in	in	ADP
admet-3091	206	32	more	more	ADV
admet-3091	206	33	consistent	consistent	ADJ
admet-3091	206	34	release	release	NOUN
admet-3091	206	35	kinetics	kinetic	NOUN
admet-3091	207	1	[	[	X
admet-3091	207	2	17,21,22	17,21,22	NUM
admet-3091	207	3	]	]	SYM
admet-3091	207	4	.	.	PUNCT
admet-3091	207	5	lipid	lipid	NOUN
admet-3091	207	6	-	-	PUNCT
admet-3091	207	7	shell	shell	NOUN
admet-3091	207	8	plga	plga	NOUN
admet-3091	207	9	core	core	NOUN
admet-3091	207	10	nanoparticles	nanoparticle	NOUN
admet-3091	207	11	produced	produce	VERB
admet-3091	207	12	via	via	ADP
admet-3091	207	13	microfluidics	microfluidic	NOUN
admet-3091	207	14	demonstrated	demonstrate	VERB
admet-3091	207	15	prolonged	prolonged	ADJ
admet-3091	207	16	release	release	NOUN
admet-3091	207	17	with	with	ADP
admet-3091	207	18	37	37	NUM
admet-3091	207	19	%	%	NOUN
admet-3091	207	20	cumulative	cumulative	ADJ
admet-3091	207	21	release	release	NOUN
admet-3091	207	22	at	at	ADP
admet-3091	207	23	72	72	NUM
admet-3091	207	24	hours	hour	NOUN
admet-3091	207	25	compared	compare	VERB
admet-3091	207	26	to	to	ADP
admet-3091	207	27	90	90	NUM
admet-3091	207	28	%	%	NOUN
admet-3091	207	29	for	for	ADP
admet-3091	207	30	conventional	conventional	ADJ
admet-3091	207	31	methods	method	NOUN
admet-3091	207	32	[	[	X
admet-3091	207	33	22	22	NUM
admet-3091	207	34	]	]	PUNCT
admet-3091	207	35	.	.	PUNCT
admet-3091	208	1	supercritical	supercritical	ADJ
admet-3091	208	2	fluid	fluid	NOUN
admet-3091	208	3	in	in	ADP
admet-3091	208	4	this	this	DET
admet-3091	208	5	relatively	relatively	ADV
admet-3091	208	6	newer	new	ADJ
admet-3091	208	7	method	method	NOUN
admet-3091	208	8	,	,	PUNCT
admet-3091	208	9	particles	particle	NOUN
admet-3091	208	10	are	be	AUX
admet-3091	208	11	formed	form	VERB
admet-3091	208	12	by	by	ADP
admet-3091	208	13	rapid	rapid	ADJ
admet-3091	208	14	depressurization	depressurization	NOUN
admet-3091	208	15	of	of	ADP
admet-3091	208	16	a	a	DET
admet-3091	208	17	saturated	saturate	VERB
admet-3091	208	18	polymer	polymer	NOUN
admet-3091	208	19	solution	solution	NOUN
admet-3091	208	20	by	by	ADP
admet-3091	208	21	nozzle	nozzle	NOUN
admet-3091	208	22	transfer	transfer	NOUN
admet-3091	208	23	.	.	PUNCT
admet-3091	209	1	co2	co2	NOUN
admet-3091	209	2	has	have	AUX
admet-3091	209	3	been	be	AUX
admet-3091	209	4	a	a	DET
admet-3091	209	5	popular	popular	ADJ
admet-3091	209	6	candidate	candidate	NOUN
admet-3091	209	7	as	as	ADP
admet-3091	209	8	a	a	DET
admet-3091	209	9	saturating	saturate	VERB
admet-3091	209	10	agent	agent	NOUN
admet-3091	209	11	due	due	ADP
admet-3091	209	12	to	to	ADP
admet-3091	209	13	enabling	enable	VERB
admet-3091	209	14	mild	mild	ADJ
admet-3091	209	15	temperature	temperature	NOUN
admet-3091	209	16	and	and	CCONJ
admet-3091	209	17	pressure	pressure	NOUN
admet-3091	209	18	conditions	condition	NOUN
admet-3091	209	19	and	and	CCONJ
admet-3091	209	20	eliminating	eliminate	VERB
admet-3091	209	21	organic	organic	ADJ
admet-3091	209	22	solvents	solvent	NOUN
admet-3091	209	23	from	from	ADP
admet-3091	209	24	the	the	DET
admet-3091	209	25	process	process	NOUN
admet-3091	209	26	.	.	PUNCT
admet-3091	210	1	key	key	ADJ
admet-3091	210	2	parameters	parameter	NOUN
admet-3091	210	3	to	to	PART
admet-3091	210	4	control	control	VERB
admet-3091	210	5	in	in	ADP
admet-3091	210	6	this	this	DET
admet-3091	210	7	technique	technique	NOUN
admet-3091	210	8	include	include	VERB
admet-3091	210	9	temperature	temperature	NOUN
admet-3091	210	10	,	,	PUNCT
admet-3091	210	11	pressure	pressure	NOUN
admet-3091	210	12	,	,	PUNCT
admet-3091	210	13	polymer	polymer	NOUN
admet-3091	210	14	concentration	concentration	NOUN
admet-3091	210	15	,	,	PUNCT
admet-3091	210	16	and	and	CCONJ
admet-3091	210	17	nozzle	nozzle	NOUN
admet-3091	210	18	diameter	diameter	NOUN
admet-3091	211	1	[	[	X
admet-3091	211	2	17,50	17,50	NUM
admet-3091	211	3	]	]	PUNCT
admet-3091	211	4	.	.	PUNCT
admet-3091	212	1	table	table	NOUN
admet-3091	212	2	2	2	NUM
admet-3091	212	3	summarizes	summarize	NOUN
admet-3091	212	4	the	the	DET
admet-3091	212	5	advantages	advantage	NOUN
admet-3091	212	6	and	and	CCONJ
admet-3091	212	7	disadvantages	disadvantage	NOUN
admet-3091	212	8	of	of	ADP
admet-3091	212	9	each	each	DET
admet-3091	212	10	formulation	formulation	NOUN
admet-3091	212	11	strategy	strategy	NOUN
admet-3091	212	12	and	and	CCONJ
admet-3091	212	13	figure	figure	NOUN
admet-3091	212	14	2	2	NUM
admet-3091	212	15	provides	provide	VERB
admet-3091	212	16	a	a	DET
admet-3091	212	17	graphical	graphical	ADJ
admet-3091	212	18	summary	summary	NOUN
admet-3091	212	19	of	of	ADP
admet-3091	212	20	each	each	DET
admet-3091	212	21	strategy	strategy	NOUN
admet-3091	212	22	.	.	PUNCT
admet-3091	213	1	table	table	NOUN
admet-3091	213	2	2	2	NUM
admet-3091	213	3	.	.	PUNCT
admet-3091	213	4	advantages	advantage	NOUN
admet-3091	213	5	and	and	CCONJ
admet-3091	213	6	disadvantages	disadvantage	NOUN
admet-3091	213	7	of	of	ADP
admet-3091	213	8	peptide	peptide	NOUN
admet-3091	213	9	-	-	PUNCT
admet-3091	213	10	loaded	load	VERB
admet-3091	213	11	plga	plga	NOUN
admet-3091	213	12	particle	particle	NOUN
admet-3091	213	13	formulation	formulation	NOUN
admet-3091	213	14	methods	method	NOUN
admet-3091	213	15	formulation	formulation	NOUN
admet-3091	213	16	method	method	NOUN
admet-3091	213	17	advantages	advantage	NOUN
admet-3091	213	18	disadvantages	disadvantage	VERB
admet-3091	213	19	single	single	ADJ
admet-3091	213	20	emulsion	emulsion	NOUN
admet-3091	213	21	(	(	PUNCT
admet-3091	213	22	o	o	NOUN
admet-3091	213	23	/	/	SYM
admet-3091	213	24	w	w	NOUN
admet-3091	213	25	)	)	PUNCT
admet-3091	213	26	and	and	CCONJ
admet-3091	213	27	double	double	ADJ
admet-3091	213	28	emulsion	emulsion	NOUN
admet-3091	213	29	(	(	PUNCT
admet-3091	213	30	w/o	w/o	PROPN
admet-3091	213	31	/	/	SYM
admet-3091	213	32	w	w	NOUN
admet-3091	213	33	)	)	PUNCT
admet-3091	213	34	enables	enable	VERB
admet-3091	213	35	encapsulating	encapsulate	VERB
admet-3091	213	36	both	both	CCONJ
admet-3091	213	37	hydrophilic	hydrophilic	ADJ
admet-3091	213	38	and	and	CCONJ
admet-3091	213	39	hydrophobic	hydrophobic	NOUN
admet-3091	213	40	peptides	peptide	NOUN
admet-3091	213	41	;	;	PUNCT
admet-3091	213	42	well	well	ADV
admet-3091	213	43	-	-	PUNCT
admet-3091	213	44	established	establish	VERB
admet-3091	213	45	protocols	protocol	NOUN
admet-3091	213	46	have	have	AUX
admet-3091	213	47	enabled	enable	VERB
admet-3091	213	48	its	its	PRON
admet-3091	213	49	application	application	NOUN
admet-3091	213	50	in	in	ADP
admet-3091	213	51	many	many	ADJ
admet-3091	213	52	commercial	commercial	ADJ
admet-3091	213	53	products	product	NOUN
admet-3091	213	54	;	;	PUNCT
admet-3091	213	55	enables	enable	VERB
admet-3091	213	56	particle	particle	NOUN
admet-3091	213	57	synthesis	synthesis	NOUN
admet-3091	213	58	in	in	ADP
admet-3091	213	59	both	both	CCONJ
admet-3091	213	60	nano	nano	ADJ
admet-3091	213	61	and	and	CCONJ
admet-3091	213	62	micro	micro	ADJ
admet-3091	213	63	scale	scale	NOUN
admet-3091	213	64	;	;	PUNCT
admet-3091	213	65	adaptable	adaptable	ADJ
admet-3091	213	66	to	to	PART
admet-3091	213	67	batch	batch	VERB
admet-3091	213	68	and	and	CCONJ
admet-3091	213	69	continuous	continuous	ADJ
admet-3091	213	70	modes	mode	NOUN
admet-3091	213	71	surfactants	surfactant	NOUN
admet-3091	213	72	complicate	complicate	VERB
admet-3091	213	73	the	the	DET
admet-3091	213	74	purification	purification	NOUN
admet-3091	213	75	process	process	NOUN
admet-3091	213	76	;	;	PUNCT
admet-3091	213	77	numerous	numerous	ADJ
admet-3091	213	78	influencing	influence	VERB
admet-3091	213	79	parameters	parameter	NOUN
admet-3091	213	80	complicate	complicate	VERB
admet-3091	213	81	reproducibility	reproducibility	NOUN
admet-3091	213	82	;	;	PUNCT
admet-3091	213	83	oil	oil	NOUN
admet-3091	213	84	/	/	SYM
admet-3091	213	85	water	water	NOUN
admet-3091	213	86	interface	interface	NOUN
admet-3091	213	87	compromises	compromise	VERB
admet-3091	213	88	peptide	peptide	VERB
admet-3091	213	89	stability	stability	NOUN
admet-3091	213	90	;	;	PUNCT
admet-3091	213	91	substantial	substantial	ADJ
admet-3091	213	92	burst	burst	ADJ
admet-3091	213	93	release	release	NOUN
admet-3091	213	94	spray	spray	NOUN
admet-3091	213	95	drying	dry	VERB
admet-3091	213	96	scale	scale	NOUN
admet-3091	213	97	up	up	ADP
admet-3091	213	98	possibility	possibility	NOUN
admet-3091	213	99	–	–	PUNCT
admet-3091	213	100	precise	precise	ADJ
admet-3091	213	101	control	control	NOUN
admet-3091	213	102	over	over	ADP
admet-3091	213	103	particle	particle	NOUN
admet-3091	213	104	size	size	NOUN
admet-3091	213	105	–	–	PUNCT
admet-3091	213	106	simple	simple	ADJ
admet-3091	213	107	one	one	NUM
admet-3091	213	108	-	-	PUNCT
admet-3091	213	109	step	step	NOUN
admet-3091	213	110	protocol	protocol	NOUN
admet-3091	213	111	the	the	DET
admet-3091	213	112	two	two	NUM
admet-3091	213	113	-	-	PUNCT
admet-3091	213	114	fluid	fluid	NOUN
admet-3091	213	115	,	,	PUNCT
admet-3091	213	116	three	three	NUM
admet-3091	213	117	-	-	PUNCT
admet-3091	213	118	fluid	fluid	ADJ
admet-3091	213	119	and	and	CCONJ
admet-3091	213	120	ultrasonic	ultrasonic	ADJ
admet-3091	213	121	atomization	atomization	NOUN
admet-3091	213	122	approaches	approach	NOUN
admet-3091	213	123	exchange	exchange	VERB
admet-3091	213	124	trade	trade	NOUN
admet-3091	213	125	-	-	PUNCT
admet-3091	213	126	offs	off	NOUN
admet-3091	213	127	on	on	ADP
admet-3091	213	128	scalability	scalability	NOUN
admet-3091	213	129	,	,	PUNCT
admet-3091	213	130	control	control	NOUN
admet-3091	213	131	on	on	ADP
admet-3091	213	132	particle	particle	NOUN
admet-3091	213	133	size	size	NOUN
admet-3091	213	134	,	,	PUNCT
admet-3091	213	135	and	and	CCONJ
admet-3091	213	136	peptide	peptide	NOUN
admet-3091	213	137	stability	stability	NOUN
admet-3091	213	138	inkjet	inkjet	NOUN
admet-3091	213	139	printing	print	VERB
admet-3091	213	140	precise	precise	ADJ
admet-3091	213	141	control	control	NOUN
admet-3091	213	142	over	over	ADP
admet-3091	213	143	particle	particle	NOUN
admet-3091	213	144	size	size	NOUN
admet-3091	213	145	and	and	CCONJ
admet-3091	213	146	morphology	morphology	NOUN
admet-3091	213	147	;	;	PUNCT
admet-3091	213	148	scalability	scalability	NOUN
admet-3091	213	149	;	;	PUNCT
admet-3091	213	150	high	high	ADJ
admet-3091	213	151	encapsulation	encapsulation	NOUN
admet-3091	213	152	efficiency	efficiency	NOUN
admet-3091	213	153	;	;	PUNCT
admet-3091	213	154	limited	limited	ADJ
admet-3091	213	155	solvent	solvent	ADJ
admet-3091	213	156	residue	residue	NOUN
admet-3091	213	157	high	high	ADJ
admet-3091	213	158	encapsulation	encapsulation	NOUN
admet-3091	213	159	efficiency	efficiency	NOUN
admet-3091	213	160	for	for	ADP
admet-3091	213	161	hydrophilic	hydrophilic	ADJ
admet-3091	213	162	peptides	peptide	NOUN
admet-3091	213	163	require	require	VERB
admet-3091	213	164	pre	pre	ADJ
admet-3091	213	165	-	-	ADJ
admet-3091	213	166	cooling	cool	VERB
admet-3091	213	167	the	the	DET
admet-3091	213	168	anti	anti	ADJ
admet-3091	213	169	-	-	ADJ
admet-3091	213	170	solvent	solvent	ADJ
admet-3091	213	171	;	;	PUNCT
admet-3091	213	172	high	high	ADJ
admet-3091	213	173	internal	internal	ADJ
admet-3091	213	174	porosity	porosity	NOUN
admet-3091	213	175	;	;	PUNCT
admet-3091	213	176	numerous	numerous	ADJ
admet-3091	213	177	influencing	influence	VERB
admet-3091	213	178	parameters	parameter	NOUN
admet-3091	213	179	from	from	ADP
admet-3091	213	180	material	material	NOUN
admet-3091	213	181	and	and	CCONJ
admet-3091	213	182	equipment	equipment	NOUN
admet-3091	213	183	require	require	VERB
admet-3091	213	184	optimization	optimization	NOUN
admet-3091	213	185	precipitation	precipitation	NOUN
admet-3091	213	186	high	high	ADJ
admet-3091	213	187	encapsulation	encapsulation	NOUN
admet-3091	213	188	efficiencyespecially	efficiencyespecially	ADV
admet-3091	213	189	for	for	ADP
admet-3091	213	190	hydrophilic	hydrophilic	ADJ
admet-3091	213	191	peptides	peptide	NOUN
admet-3091	213	192	;	;	PUNCT
admet-3091	213	193	reduces	reduce	VERB
admet-3091	213	194	burst	burst	ADJ
admet-3091	213	195	release	release	NOUN
admet-3091	213	196	;	;	PUNCT
admet-3091	213	197	limits	limit	NOUN
admet-3091	213	198	peptide	peptide	ADJ
admet-3091	213	199	stability	stability	NOUN
admet-3091	213	200	issues	issue	NOUN
admet-3091	213	201	multiple	multiple	ADJ
admet-3091	213	202	residual	residual	ADJ
admet-3091	213	203	solvents	solvent	NOUN
admet-3091	213	204	to	to	PART
admet-3091	213	205	remove	remove	VERB
admet-3091	213	206	complicate	complicate	VERB
admet-3091	213	207	the	the	DET
admet-3091	213	208	purification	purification	NOUN
admet-3091	213	209	process	process	NOUN
admet-3091	213	210	and	and	CCONJ
admet-3091	213	211	raise	raise	VERB
admet-3091	213	212	taxological	taxological	ADJ
admet-3091	213	213	concern	concern	NOUN
admet-3091	213	214	;	;	PUNCT
admet-3091	213	215	scale	scale	NOUN
admet-3091	213	216	-	-	PUNCT
admet-3091	213	217	up	up	ADP
admet-3091	213	218	challenges	challenge	NOUN
admet-3091	213	219	;	;	PUNCT
admet-3091	213	220	batch	batch	NOUN
admet-3091	213	221	-	-	PUNCT
admet-3091	213	222	to	to	ADP
admet-3091	213	223	-	-	PUNCT
admet-3091	213	224	batch	batch	NOUN
admet-3091	213	225	variability	variability	NOUN
admet-3091	213	226	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	213	227	m.	m.	PROPN
admet-3091	213	228	eshaghi	eshaghi	PROPN
admet-3091	213	229	et	et	PROPN
admet-3091	213	230	al	al	PROPN
admet-3091	213	231	.	.	PROPN
admet-3091	213	232	admet	admet	PROPN
admet-3091	213	233	&	&	CCONJ
admet-3091	213	234	dmpk	dmpk	PROPN
admet-3091	213	235	00(0	00(0	PROPN
admet-3091	213	236	)	)	PUNCT
admet-3091	213	237	(	(	PUNCT
admet-3091	213	238	2025	2025	NUM
admet-3091	213	239	)	)	PUNCT
admet-3091	213	240	3091	3091	NUM
admet-3091	213	241	10	10	NUM
admet-3091	213	242	formulation	formulation	NOUN
admet-3091	213	243	method	method	NOUN
admet-3091	213	244	advantages	advantage	NOUN
admet-3091	213	245	disadvantages	disadvantage	VERB
admet-3091	213	246	microfluidic	microfluidic	ADJ
admet-3091	213	247	methods	method	NOUN
admet-3091	213	248	precise	precise	ADJ
admet-3091	213	249	control	control	NOUN
admet-3091	213	250	over	over	ADP
admet-3091	213	251	particle	particle	NOUN
admet-3091	213	252	size	size	NOUN
admet-3091	213	253	and	and	CCONJ
admet-3091	213	254	morphology	morphology	NOUN
admet-3091	213	255	;	;	PUNCT
admet-3091	213	256	reduced	reduce	VERB
admet-3091	213	257	batch	batch	NOUN
admet-3091	213	258	-	-	PUNCT
admet-3091	213	259	to	to	ADP
admet-3091	213	260	-	-	PUNCT
admet-3091	213	261	batch	batch	NOUN
admet-3091	213	262	variability	variability	NOUN
admet-3091	213	263	;	;	PUNCT
admet-3091	213	264	high	high	ADJ
admet-3091	213	265	encapsulation	encapsulation	NOUN
admet-3091	213	266	efficiency	efficiency	NOUN
admet-3091	213	267	;	;	PUNCT
admet-3091	213	268	limits	limit	NOUN
admet-3091	213	269	peptide	peptide	ADJ
admet-3091	213	270	stability	stability	NOUN
admet-3091	213	271	issues	issue	NOUN
admet-3091	213	272	scale	scale	NOUN
admet-3091	213	273	-	-	PUNCT
admet-3091	213	274	up	up	ADP
admet-3091	213	275	challenges	challenge	NOUN
admet-3091	213	276	;	;	PUNCT
admet-3091	213	277	process	process	NOUN
admet-3091	213	278	complexity	complexity	NOUN
admet-3091	213	279	and	and	CCONJ
admet-3091	213	280	parameter	parameter	NOUN
admet-3091	213	281	sensitivity	sensitivity	NOUN
admet-3091	213	282	;	;	PUNCT
admet-3091	213	283	incompetence	incompetence	NOUN
admet-3091	213	284	for	for	ADP
admet-3091	213	285	producing	produce	VERB
admet-3091	213	286	microparticles	microparticle	NOUN
admet-3091	213	287	;	;	PUNCT
admet-3091	213	288	quality	quality	NOUN
admet-3091	213	289	control	control	NOUN
admet-3091	213	290	challenges	challenge	VERB
admet-3091	213	291	supercritical	supercritical	ADJ
admet-3091	213	292	fluid	fluid	NOUN
admet-3091	213	293	environmentally	environmentally	ADV
admet-3091	213	294	friendly	friendly	ADJ
admet-3091	213	295	and	and	CCONJ
admet-3091	213	296	solvent	solvent	NOUN
admet-3091	213	297	-	-	PUNCT
admet-3091	213	298	free	free	ADJ
admet-3091	213	299	;	;	PUNCT
admet-3091	213	300	excellent	excellent	ADJ
admet-3091	213	301	process	process	NOUN
admet-3091	213	302	control	control	NOUN
admet-3091	213	303	and	and	CCONJ
admet-3091	213	304	reduced	reduced	ADJ
admet-3091	213	305	batch	batch	NOUN
admet-3091	213	306	-	-	PUNCT
admet-3091	213	307	to	to	ADP
admet-3091	213	308	-	-	PUNCT
admet-3091	213	309	batch	batch	NOUN
admet-3091	213	310	variability	variability	NOUN
admet-3091	213	311	;	;	PUNCT
admet-3091	213	312	high	high	ADJ
admet-3091	213	313	encapsulation	encapsulation	NOUN
admet-3091	213	314	efficiency	efficiency	NOUN
admet-3091	213	315	limited	limit	VERB
admet-3091	213	316	plga	plga	NOUN
admet-3091	213	317	and	and	CCONJ
admet-3091	213	318	hydrophilic	hydrophilic	ADJ
admet-3091	213	319	peptide	peptide	NOUN
admet-3091	213	320	solubility	solubility	NOUN
admet-3091	213	321	in	in	ADP
admet-3091	213	322	supercritical	supercritical	ADJ
admet-3091	213	323	co2	co2	NOUN
admet-3091	213	324	;	;	PUNCT
admet-3091	213	325	expensive	expensive	ADJ
admet-3091	213	326	equipment	equipment	NOUN
admet-3091	213	327	;	;	PUNCT
admet-3091	213	328	challenges	challenge	NOUN
admet-3091	213	329	in	in	ADP
admet-3091	213	330	controlling	control	VERB
admet-3091	213	331	aggregation	aggregation	NOUN
admet-3091	213	332	and	and	CCONJ
admet-3091	213	333	particle	particle	NOUN
admet-3091	213	334	size	size	NOUN
admet-3091	213	335	;	;	PUNCT
admet-3091	213	336	scale	scale	NOUN
admet-3091	213	337	-	-	PUNCT
admet-3091	213	338	up	up	NOUN
admet-3091	213	339	challenges	challenge	NOUN
admet-3091	213	340	figure	figure	VERB
admet-3091	213	341	2	2	NUM
admet-3091	213	342	.	.	PUNCT
admet-3091	213	343	formulation	formulation	NOUN
admet-3091	213	344	strategies	strategy	NOUN
admet-3091	213	345	for	for	ADP
admet-3091	213	346	controlled	control	VERB
admet-3091	213	347	release	release	NOUN
admet-3091	213	348	advanced	advanced	ADJ
admet-3091	213	349	delivery	delivery	NOUN
admet-3091	213	350	systems	system	NOUN
admet-3091	213	351	plga	plga	NOUN
admet-3091	213	352	microand	microand	NOUN
admet-3091	213	353	nanoparticles	nanoparticle	NOUN
admet-3091	213	354	have	have	AUX
admet-3091	213	355	garnered	garner	VERB
admet-3091	213	356	significant	significant	ADJ
admet-3091	213	357	attention	attention	NOUN
admet-3091	213	358	as	as	ADP
admet-3091	213	359	efficient	efficient	ADJ
admet-3091	213	360	drug	drug	NOUN
admet-3091	213	361	delivery	delivery	NOUN
admet-3091	213	362	systems	system	NOUN
admet-3091	213	363	due	due	ADP
admet-3091	213	364	to	to	ADP
admet-3091	213	365	their	their	PRON
admet-3091	213	366	ability	ability	NOUN
admet-3091	213	367	to	to	PART
admet-3091	213	368	improve	improve	VERB
admet-3091	213	369	the	the	DET
admet-3091	213	370	pharmacokinetics	pharmacokinetic	NOUN
admet-3091	213	371	and	and	CCONJ
admet-3091	213	372	therapeutic	therapeutic	ADJ
admet-3091	213	373	index	index	NOUN
admet-3091	213	374	of	of	ADP
admet-3091	213	375	encapsulated	encapsulate	VERB
admet-3091	213	376	drugs	drug	NOUN
admet-3091	213	377	.	.	PUNCT
admet-3091	214	1	these	these	DET
admet-3091	214	2	carriers	carrier	NOUN
admet-3091	214	3	provide	provide	VERB
admet-3091	214	4	controlled	control	VERB
admet-3091	214	5	and	and	CCONJ
admet-3091	214	6	sustained	sustained	ADJ
admet-3091	214	7	drug	drug	NOUN
admet-3091	214	8	release	release	NOUN
admet-3091	214	9	,	,	PUNCT
admet-3091	214	10	reduce	reduce	VERB
admet-3091	214	11	drug	drug	NOUN
admet-3091	214	12	clearance	clearance	NOUN
admet-3091	214	13	,	,	PUNCT
admet-3091	214	14	and	and	CCONJ
admet-3091	214	15	enhance	enhance	VERB
admet-3091	214	16	bioavailability	bioavailability	NOUN
admet-3091	214	17	,	,	PUNCT
admet-3091	214	18	making	make	VERB
admet-3091	214	19	them	they	PRON
admet-3091	214	20	ideal	ideal	ADJ
admet-3091	214	21	for	for	ADP
admet-3091	214	22	both	both	CCONJ
admet-3091	214	23	systemic	systemic	ADJ
admet-3091	214	24	and	and	CCONJ
admet-3091	214	25	localized	localized	ADJ
admet-3091	214	26	delivery	delivery	NOUN
admet-3091	214	27	.	.	PUNCT
admet-3091	215	1	plga	plga	NOUN
admet-3091	215	2	protects	protect	VERB
admet-3091	215	3	sensitive	sensitive	ADJ
admet-3091	215	4	drugs	drug	NOUN
admet-3091	215	5	from	from	ADP
admet-3091	215	6	enzymatic	enzymatic	ADJ
admet-3091	215	7	and	and	CCONJ
admet-3091	215	8	chemical	chemical	NOUN
admet-3091	215	9	degradation	degradation	NOUN
admet-3091	215	10	,	,	PUNCT
admet-3091	215	11	enabling	enable	VERB
admet-3091	215	12	the	the	DET
admet-3091	215	13	delivery	delivery	NOUN
admet-3091	215	14	of	of	ADP
admet-3091	215	15	a	a	DET
admet-3091	215	16	broad	broad	ADJ
admet-3091	215	17	spectrum	spectrum	NOUN
admet-3091	215	18	of	of	ADP
admet-3091	215	19	therapeutics	therapeutic	NOUN
admet-3091	215	20	,	,	PUNCT
admet-3091	215	21	including	include	VERB
admet-3091	215	22	anticancer	anticancer	NOUN
admet-3091	215	23	agents	agent	NOUN
admet-3091	215	24	,	,	PUNCT
admet-3091	215	25	anti	anti	ADJ
admet-3091	215	26	-	-	ADJ
admet-3091	215	27	inflammatory	inflammatory	ADJ
admet-3091	215	28	drugs	drug	NOUN
admet-3091	215	29	,	,	PUNCT
admet-3091	215	30	and	and	CCONJ
admet-3091	215	31	antibiotics	antibiotic	NOUN
admet-3091	215	32	.	.	PUNCT
admet-3091	216	1	moreover	moreover	ADV
admet-3091	216	2	,	,	PUNCT
admet-3091	216	3	the	the	DET
admet-3091	216	4	versatility	versatility	NOUN
admet-3091	216	5	in	in	ADP
admet-3091	216	6	formulation	formulation	NOUN
admet-3091	216	7	methods	method	NOUN
admet-3091	216	8	allows	allow	VERB
admet-3091	216	9	the	the	DET
admet-3091	216	10	encapsulation	encapsulation	NOUN
admet-3091	216	11	of	of	ADP
admet-3091	216	12	drugs	drug	NOUN
admet-3091	216	13	with	with	ADP
admet-3091	216	14	diverse	diverse	ADJ
admet-3091	216	15	physicochemical	physicochemical	ADJ
admet-3091	216	16	properties	property	NOUN
admet-3091	216	17	,	,	PUNCT
admet-3091	216	18	addressing	address	VERB
admet-3091	216	19	solubility	solubility	NOUN
admet-3091	216	20	and	and	CCONJ
admet-3091	216	21	stability	stability	NOUN
admet-3091	216	22	challenges	challenge	NOUN
admet-3091	216	23	commonly	commonly	ADV
admet-3091	216	24	encountered	encounter	VERB
admet-3091	216	25	in	in	ADP
admet-3091	216	26	conventional	conventional	ADJ
admet-3091	216	27	drug	drug	NOUN
admet-3091	216	28	delivery	delivery	NOUN
admet-3091	216	29	.	.	PUNCT
admet-3091	217	1	admet	admet	PROPN
admet-3091	217	2	&	&	CCONJ
admet-3091	217	3	dmpk	dmpk	PROPN
admet-3091	217	4	00(0	00(0	PROPN
admet-3091	217	5	)	)	PUNCT
admet-3091	217	6	(	(	PUNCT
admet-3091	217	7	2025	2025	NUM
admet-3091	217	8	)	)	PUNCT
admet-3091	217	9	3091	3091	NUM
admet-3091	217	10	plga	plga	NOUN
admet-3091	217	11	nanoparticles	nanoparticle	NOUN
admet-3091	217	12	and	and	CCONJ
admet-3091	217	13	microparticles	microparticle	NOUN
admet-3091	217	14	for	for	ADP
admet-3091	217	15	peptide	peptide	ADJ
admet-3091	217	16	delivery	delivery	NOUN
admet-3091	217	17	doi	doi	NOUN
admet-3091	217	18	:	:	PUNCT
admet-3091	217	19	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	X
admet-3091	217	20	11	11	NUM
admet-3091	217	21	multi	multi	ADJ
admet-3091	217	22	-	-	ADJ
admet-3091	217	23	compartment	compartment	ADJ
admet-3091	217	24	systems	system	NOUN
admet-3091	217	25	nano	nano	NOUN
admet-3091	217	26	-	-	PUNCT
admet-3091	217	27	in	in	ADP
admet-3091	217	28	-	-	PUNCT
admet-3091	217	29	micro	micro	NOUN
admet-3091	217	30	systems	system	NOUN
admet-3091	217	31	:	:	PUNCT
admet-3091	217	32	these	these	DET
admet-3091	217	33	systems	system	NOUN
admet-3091	217	34	combine	combine	VERB
admet-3091	217	35	the	the	DET
admet-3091	217	36	advantages	advantage	NOUN
admet-3091	217	37	of	of	ADP
admet-3091	217	38	both	both	DET
admet-3091	217	39	size	size	NOUN
admet-3091	217	40	scales	scale	NOUN
admet-3091	217	41	,	,	PUNCT
admet-3091	217	42	with	with	ADP
admet-3091	217	43	nanoparticles	nanoparticle	NOUN
admet-3091	217	44	providing	provide	VERB
admet-3091	217	45	cellular	cellular	ADJ
admet-3091	217	46	uptake	uptake	NOUN
admet-3091	217	47	and	and	CCONJ
admet-3091	217	48	microparticles	microparticle	NOUN
admet-3091	217	49	offering	offer	VERB
admet-3091	217	50	sustained	sustained	ADJ
admet-3091	217	51	release	release	NOUN
admet-3091	217	52	.	.	PUNCT
admet-3091	218	1	plga	plga	NOUN
admet-3091	218	2	nanoparticles	nanoparticle	NOUN
admet-3091	218	3	encapsulated	encapsulate	VERB
admet-3091	218	4	within	within	ADP
admet-3091	218	5	yeast	yeast	NOUN
admet-3091	218	6	cell	cell	NOUN
admet-3091	218	7	wall	wall	NOUN
admet-3091	218	8	particles	particle	NOUN
admet-3091	218	9	demonstrated	demonstrate	VERB
admet-3091	218	10	reduced	reduce	VERB
admet-3091	218	11	burst	burst	ADJ
admet-3091	218	12	release	release	NOUN
admet-3091	218	13	and	and	CCONJ
admet-3091	218	14	prolonged	prolong	VERB
admet-3091	218	15	hypoglycemic	hypoglycemic	ADJ
admet-3091	218	16	effects	effect	NOUN
admet-3091	218	17	of	of	ADP
admet-3091	218	18	exenatide	exenatide	NOUN
admet-3091	218	19	peptide	peptide	NOUN
admet-3091	218	20	,	,	PUNCT
admet-3091	218	21	exceeding	exceed	VERB
admet-3091	218	22	12	12	NUM
admet-3091	218	23	hours	hour	NOUN
admet-3091	218	24	[	[	X
admet-3091	218	25	51	51	NUM
admet-3091	218	26	]	]	PUNCT
admet-3091	218	27	.	.	PUNCT
admet-3091	219	1	core	core	ADJ
admet-3091	219	2	-	-	PUNCT
admet-3091	219	3	shell	shell	NOUN
admet-3091	219	4	architectures	architecture	NOUN
admet-3091	219	5	:	:	PUNCT
admet-3091	219	6	this	this	DET
admet-3091	219	7	approach	approach	NOUN
admet-3091	219	8	enables	enable	VERB
admet-3091	219	9	sequential	sequential	ADJ
admet-3091	219	10	release	release	NOUN
admet-3091	219	11	profiles	profile	NOUN
admet-3091	219	12	and	and	CCONJ
admet-3091	219	13	improved	improve	VERB
admet-3091	219	14	stability	stability	NOUN
admet-3091	219	15	.	.	PUNCT
admet-3091	220	1	lipidshell	lipidshell	PROPN
admet-3091	220	2	plga	plga	VERB
admet-3091	220	3	core	core	NOUN
admet-3091	220	4	nanoparticles	nanoparticle	NOUN
admet-3091	220	5	showed	show	VERB
admet-3091	220	6	33	33	NUM
admet-3091	220	7	%	%	NOUN
admet-3091	220	8	reduction	reduction	NOUN
admet-3091	220	9	in	in	ADP
admet-3091	220	10	burst	burst	ADJ
admet-3091	220	11	release	release	NOUN
admet-3091	220	12	compared	compare	VERB
admet-3091	220	13	to	to	ADP
admet-3091	220	14	plga	plga	VERB
admet-3091	220	15	-	-	PUNCT
admet-3091	220	16	only	only	ADV
admet-3091	220	17	formulations	formulation	NOUN
admet-3091	220	18	while	while	SCONJ
admet-3091	220	19	maintaining	maintaining	AUX
admet-3091	220	20	prolonged	prolonged	ADJ
admet-3091	220	21	antihypertensive	antihypertensive	ADJ
admet-3091	220	22	effects	effect	NOUN
admet-3091	220	23	of	of	ADP
admet-3091	220	24	ky5	ky5	NOUN
admet-3091	220	25	peptide	peptide	NOUN
admet-3091	220	26	for	for	ADP
admet-3091	220	27	144	144	NUM
admet-3091	220	28	hours	hour	NOUN
admet-3091	221	1	[	[	X
admet-3091	221	2	52	52	NUM
admet-3091	221	3	]	]	PUNCT
admet-3091	221	4	.	.	PUNCT
admet-3091	222	1	stimuli	stimuli	VERB
admet-3091	222	2	-	-	PUNCT
admet-3091	222	3	responsive	responsive	ADJ
admet-3091	222	4	systems	system	NOUN
admet-3091	222	5	ph	ph	ADJ
admet-3091	222	6	-	-	PUNCT
admet-3091	222	7	responsive	responsive	ADJ
admet-3091	222	8	systems	system	NOUN
admet-3091	222	9	:	:	PUNCT
admet-3091	222	10	these	these	DET
admet-3091	222	11	systems	system	NOUN
admet-3091	222	12	exploit	exploit	VERB
admet-3091	222	13	physiological	physiological	ADJ
admet-3091	222	14	ph	ph	NOUN
admet-3091	222	15	variations	variation	NOUN
admet-3091	222	16	for	for	ADP
admet-3091	222	17	targeted	target	VERB
admet-3091	222	18	delivery	delivery	NOUN
admet-3091	222	19	.	.	PUNCT
admet-3091	223	1	entericcoated	entericcoate	VERB
admet-3091	223	2	plga	plga	NOUN
admet-3091	223	3	nanoparticles	nanoparticle	NOUN
admet-3091	223	4	showed	show	VERB
admet-3091	223	5	limited	limited	ADJ
admet-3091	223	6	gastric	gastric	ADJ
admet-3091	223	7	release	release	NOUN
admet-3091	223	8	of	of	ADP
admet-3091	223	9	vlpvpr	vlpvpr	NOUN
admet-3091	223	10	peptide	peptide	NOUN
admet-3091	223	11	(	(	PUNCT
admet-3091	223	12	<	<	X
admet-3091	223	13	40	40	NUM
admet-3091	223	14	%	%	NOUN
admet-3091	223	15	at	at	ADP
admet-3091	223	16	ph	ph	PROPN
admet-3091	223	17	1.0	1.0	NUM
admet-3091	223	18	)	)	PUNCT
admet-3091	223	19	while	while	SCONJ
admet-3091	223	20	enabling	enable	VERB
admet-3091	223	21	complete	complete	ADJ
admet-3091	223	22	intestinal	intestinal	ADJ
admet-3091	223	23	release	release	NOUN
admet-3091	223	24	(	(	PUNCT
admet-3091	223	25	100	100	NUM
admet-3091	223	26	%	%	NOUN
admet-3091	223	27	at	at	ADP
admet-3091	223	28	ph	ph	PROPN
admet-3091	223	29	7.4	7.4	NUM
admet-3091	223	30	)	)	PUNCT
admet-3091	223	31	within	within	ADP
admet-3091	223	32	8	8	NUM
admet-3091	223	33	hours	hour	NOUN
admet-3091	223	34	[	[	X
admet-3091	223	35	53	53	NUM
admet-3091	223	36	]	]	PUNCT
admet-3091	223	37	.	.	PUNCT
admet-3091	224	1	enzyme	enzyme	NOUN
admet-3091	224	2	-	-	PUNCT
admet-3091	224	3	responsive	responsive	ADJ
admet-3091	224	4	systems	system	NOUN
admet-3091	225	1	:	:	PUNCT
admet-3091	225	2	these	these	DET
admet-3091	225	3	systems	system	NOUN
admet-3091	225	4	use	use	VERB
admet-3091	225	5	specific	specific	ADJ
admet-3091	225	6	enzymatic	enzymatic	ADJ
admet-3091	225	7	activity	activity	NOUN
admet-3091	225	8	to	to	PART
admet-3091	225	9	enable	enable	VERB
admet-3091	225	10	controlled	control	VERB
admet-3091	225	11	release	release	NOUN
admet-3091	225	12	.	.	PUNCT
admet-3091	226	1	plga	plga	NOUN
admet-3091	226	2	/	/	SYM
admet-3091	226	3	collagen	collagen	NOUN
admet-3091	226	4	microparticles	microparticle	NOUN
admet-3091	226	5	containing	contain	VERB
admet-3091	226	6	collagen	collagen	NOUN
admet-3091	226	7	-	-	PUNCT
admet-3091	226	8	binding	bind	VERB
admet-3091	226	9	gdnf	gdnf	NOUN
admet-3091	226	10	exhibited	exhibit	VERB
admet-3091	226	11	enzyme	enzyme	NOUN
admet-3091	226	12	-	-	PUNCT
admet-3091	226	13	dependent	dependent	ADJ
admet-3091	226	14	release	release	NOUN
admet-3091	226	15	rates	rate	NOUN
admet-3091	226	16	ranging	range	VERB
admet-3091	226	17	from	from	ADP
admet-3091	226	18	8	8	NUM
admet-3091	226	19	to	to	ADP
admet-3091	226	20	250	250	NUM
admet-3091	226	21	ng	ng	PROPN
admet-3091	226	22	mg-1	mg-1	PROPN
admet-3091	226	23	,	,	PUNCT
admet-3091	226	24	depending	depend	VERB
admet-3091	226	25	on	on	ADP
admet-3091	226	26	collagenase	collagenase	ADJ
admet-3091	226	27	concentration	concentration	NOUN
admet-3091	226	28	[	[	X
admet-3091	226	29	29	29	NUM
admet-3091	226	30	]	]	PUNCT
admet-3091	226	31	.	.	PUNCT
admet-3091	227	1	in	in	ADP
admet-3091	227	2	vitro	vitro	NOUN
admet-3091	227	3	-	-	PUNCT
admet-3091	227	4	in	in	ADP
admet-3091	227	5	vivo	vivo	NOUN
admet-3091	227	6	correlations	correlation	NOUN
admet-3091	227	7	establishing	establish	VERB
admet-3091	227	8	predictive	predictive	ADJ
admet-3091	227	9	relationships	relationship	NOUN
admet-3091	227	10	between	between	ADP
admet-3091	227	11	in	in	ADP
admet-3091	227	12	vitro	vitro	X
admet-3091	227	13	and	and	CCONJ
admet-3091	227	14	in	in	ADP
admet-3091	227	15	vivo	vivo	ADJ
admet-3091	227	16	release	release	NOUN
admet-3091	227	17	remains	remain	VERB
admet-3091	227	18	challenging	challenge	VERB
admet-3091	227	19	for	for	ADP
admet-3091	227	20	plga	plga	NOUN
admet-3091	227	21	-	-	PUNCT
admet-3091	227	22	peptide	peptide	NOUN
admet-3091	227	23	systems	system	NOUN
admet-3091	227	24	,	,	PUNCT
admet-3091	227	25	as	as	SCONJ
admet-3091	227	26	indicated	indicate	VERB
admet-3091	227	27	in	in	ADP
admet-3091	227	28	figure	figure	NOUN
admet-3091	227	29	3	3	NUM
admet-3091	227	30	.	.	PUNCT
admet-3091	227	31	peptide	peptide	NOUN
admet-3091	227	32	release	release	NOUN
admet-3091	227	33	often	often	ADV
admet-3091	227	34	occurs	occur	VERB
admet-3091	227	35	more	more	ADV
admet-3091	227	36	rapidly	rapidly	ADV
admet-3091	227	37	in	in	ADP
admet-3091	227	38	vivo	vivo	NOUN
admet-3091	227	39	than	than	ADP
admet-3091	227	40	in	in	ADP
admet-3091	227	41	vitro	vitro	X
admet-3091	227	42	due	due	ADP
admet-3091	227	43	to	to	ADP
admet-3091	227	44	enhanced	enhanced	ADJ
admet-3091	227	45	swelling	swelling	NOUN
admet-3091	227	46	,	,	PUNCT
admet-3091	227	47	enzymatic	enzymatic	ADJ
admet-3091	227	48	degradation	degradation	NOUN
admet-3091	227	49	,	,	PUNCT
admet-3091	227	50	and	and	CCONJ
admet-3091	227	51	mechanical	mechanical	ADJ
admet-3091	227	52	stress	stress	NOUN
admet-3091	227	53	at	at	ADP
admet-3091	227	54	injection	injection	NOUN
admet-3091	227	55	sites	site	NOUN
admet-3091	227	56	.	.	PUNCT
admet-3091	228	1	comparative	comparative	ADJ
admet-3091	228	2	studies	study	NOUN
admet-3091	228	3	reveal	reveal	VERB
admet-3091	228	4	significant	significant	ADJ
admet-3091	228	5	variations	variation	NOUN
admet-3091	228	6	in	in	ADP
admet-3091	228	7	in	in	ADP
admet-3091	228	8	vivo	vivo	NOUN
admet-3091	228	9	/	/	SYM
admet-3091	228	10	in	in	X
admet-3091	228	11	vitro	vitro	X
admet-3091	228	12	ratios	ratio	NOUN
admet-3091	228	13	across	across	ADP
admet-3091	228	14	different	different	ADJ
admet-3091	228	15	peptides	peptide	NOUN
admet-3091	228	16	and	and	CCONJ
admet-3091	228	17	formulations	formulation	NOUN
admet-3091	228	18	.	.	PUNCT
admet-3091	229	1	for	for	ADP
admet-3091	229	2	example	example	NOUN
admet-3091	229	3	,	,	PUNCT
admet-3091	229	4	exenatide	exenatide	INTJ
admet-3091	229	5	formulated	formulate	VERB
admet-3091	229	6	with	with	ADP
admet-3091	229	7	28	28	NUM
admet-3091	229	8	kda	kda	NOUN
admet-3091	229	9	plga	plga	NOUN
admet-3091	229	10	was	be	AUX
admet-3091	229	11	entirely	entirely	ADV
admet-3091	229	12	released	release	VERB
admet-3091	229	13	over	over	ADP
admet-3091	229	14	63	63	NUM
admet-3091	229	15	days	day	NOUN
admet-3091	229	16	in	in	ADP
admet-3091	229	17	vitro	vitro	X
admet-3091	229	18	but	but	CCONJ
admet-3091	229	19	only	only	ADV
admet-3091	229	20	28	28	NUM
admet-3091	229	21	days	day	NOUN
admet-3091	229	22	in	in	ADP
admet-3091	229	23	vivo	vivo	NOUN
admet-3091	229	24	,	,	PUNCT
admet-3091	229	25	with	with	ADP
admet-3091	229	26	in	in	ADP
admet-3091	229	27	vivo	vivo	NOUN
admet-3091	229	28	/	/	SYM
admet-3091	229	29	in	in	X
admet-3091	229	30	vitro	vitro	X
admet-3091	229	31	ratios	ratio	NOUN
admet-3091	229	32	of	of	ADP
admet-3091	229	33	1.72	1.72	NUM
admet-3091	229	34	,	,	PUNCT
admet-3091	229	35	1.85	1.85	NUM
admet-3091	229	36	,	,	PUNCT
admet-3091	229	37	and	and	CCONJ
admet-3091	229	38	1.08	1.08	NUM
admet-3091	229	39	at	at	ADP
admet-3091	229	40	10	10	NUM
admet-3091	229	41	,	,	PUNCT
admet-3091	229	42	50	50	NUM
admet-3091	229	43	and	and	CCONJ
admet-3091	229	44	100	100	NUM
admet-3091	229	45	%	%	NOUN
admet-3091	229	46	release	release	NOUN
admet-3091	229	47	,	,	PUNCT
admet-3091	229	48	respectively	respectively	ADV
admet-3091	229	49	.	.	PUNCT
admet-3091	230	1	strategies	strategy	NOUN
admet-3091	230	2	to	to	PART
admet-3091	230	3	improve	improve	VERB
admet-3091	230	4	correlation	correlation	NOUN
admet-3091	230	5	include	include	VERB
admet-3091	230	6	using	use	VERB
admet-3091	230	7	release	release	NOUN
admet-3091	230	8	media	medium	NOUN
admet-3091	230	9	that	that	PRON
admet-3091	230	10	mimic	mimic	VERB
admet-3091	230	11	in	in	ADP
admet-3091	230	12	vivo	vivo	ADJ
admet-3091	230	13	environments	environment	NOUN
admet-3091	230	14	,	,	PUNCT
admet-3091	230	15	incorporating	incorporate	VERB
admet-3091	230	16	serum	serum	NOUN
admet-3091	230	17	proteins	protein	NOUN
admet-3091	230	18	,	,	PUNCT
admet-3091	230	19	and	and	CCONJ
admet-3091	230	20	developing	develop	VERB
admet-3091	230	21	formulationspecific	formulationspecific	ADJ
admet-3091	230	22	models	model	NOUN
admet-3091	230	23	[	[	X
admet-3091	230	24	53,54	53,54	NUM
admet-3091	230	25	]	]	PUNCT
admet-3091	230	26	.	.	PUNCT
admet-3091	231	1	figure	figure	NOUN
admet-3091	231	2	3	3	NUM
admet-3091	231	3	.	.	PUNCT
admet-3091	232	1	the	the	DET
admet-3091	232	2	gap	gap	NOUN
admet-3091	232	3	between	between	ADP
admet-3091	232	4	in	in	ADP
admet-3091	232	5	vitro	vitro	X
admet-3091	232	6	and	and	CCONJ
admet-3091	232	7	in	in	ADP
admet-3091	232	8	vivo	vivo	ADJ
admet-3091	232	9	release	release	NOUN
admet-3091	232	10	assay	assay	NOUN
admet-3091	232	11	results	result	NOUN
admet-3091	232	12	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	X
admet-3091	232	13	m.	m.	PROPN
admet-3091	232	14	eshaghi	eshaghi	PROPN
admet-3091	232	15	et	et	PROPN
admet-3091	232	16	al	al	PROPN
admet-3091	232	17	.	.	PROPN
admet-3091	232	18	admet	admet	PROPN
admet-3091	232	19	&	&	CCONJ
admet-3091	232	20	dmpk	dmpk	PROPN
admet-3091	232	21	00(0	00(0	PROPN
admet-3091	232	22	)	)	PUNCT
admet-3091	232	23	(	(	PUNCT
admet-3091	232	24	2025	2025	NUM
admet-3091	232	25	)	)	PUNCT
admet-3091	232	26	3091	3091	NUM
admet-3091	232	27	12	12	NUM
admet-3091	232	28	clinical	clinical	ADJ
admet-3091	232	29	applications	application	NOUN
admet-3091	232	30	and	and	CCONJ
admet-3091	232	31	marketed	market	VERB
admet-3091	232	32	products	product	NOUN
admet-3091	232	33	several	several	ADJ
admet-3091	232	34	plga	plga	NOUN
admet-3091	232	35	-	-	PUNCT
admet-3091	232	36	based	base	VERB
admet-3091	232	37	peptide	peptide	NOUN
admet-3091	232	38	delivery	delivery	NOUN
admet-3091	232	39	systems	system	NOUN
admet-3091	232	40	have	have	AUX
admet-3091	232	41	achieved	achieve	VERB
admet-3091	232	42	clinical	clinical	ADJ
admet-3091	232	43	success	success	NOUN
admet-3091	232	44	,	,	PUNCT
admet-3091	232	45	demonstrating	demonstrate	VERB
admet-3091	232	46	the	the	DET
admet-3091	232	47	technology	technology	NOUN
admet-3091	232	48	's	's	PART
admet-3091	232	49	commercial	commercial	ADJ
admet-3091	232	50	viability	viability	NOUN
admet-3091	232	51	.	.	PUNCT
admet-3091	233	1	lupron	lupron	NOUN
admet-3091	233	2	depot	depot	NOUN
admet-3091	233	3	®	®	NOUN
admet-3091	233	4	utilizes	utilize	VERB
admet-3091	233	5	75:25	75:25	NUM
admet-3091	233	6	plga	plga	NOUN
admet-3091	233	7	microspheres	microsphere	NOUN
admet-3091	233	8	containing	contain	VERB
admet-3091	233	9	10	10	NUM
admet-3091	233	10	%	%	NOUN
admet-3091	233	11	leuprolide	leuprolide	NOUN
admet-3091	233	12	acetate	acetate	NOUN
admet-3091	233	13	for	for	ADP
admet-3091	233	14	monthly	monthly	ADJ
admet-3091	233	15	testosterone	testosterone	NOUN
admet-3091	233	16	suppression	suppression	NOUN
admet-3091	233	17	in	in	ADP
admet-3091	233	18	prostate	prostate	NOUN
admet-3091	233	19	cancer	cancer	NOUN
admet-3091	233	20	treatment	treatment	NOUN
admet-3091	233	21	.	.	PUNCT
admet-3091	234	1	suprecur	suprecur	PROPN
admet-3091	234	2	®	®	PROPN
admet-3091	234	3	mp	mp	PROPN
admet-3091	234	4	,	,	PUNCT
admet-3091	234	5	decapeptyl	decapeptyl	VERB
admet-3091	234	6	®	®	NOUN
admet-3091	234	7	and	and	CCONJ
admet-3091	234	8	trelstar	trelstar	VERB
admet-3091	234	9	™	™	ADJ
admet-3091	234	10	depot	depot	NOUN
admet-3091	234	11	are	be	AUX
admet-3091	234	12	other	other	ADJ
admet-3091	234	13	marketed	market	VERB
admet-3091	234	14	plga	plga	NOUN
admet-3091	234	15	-	-	PUNCT
admet-3091	234	16	based	base	VERB
admet-3091	234	17	formulations	formulation	NOUN
admet-3091	234	18	for	for	ADP
admet-3091	234	19	prostate	prostate	NOUN
admet-3091	234	20	cancer	cancer	NOUN
admet-3091	234	21	[	[	X
admet-3091	234	22	55,56	55,56	NOUN
admet-3091	234	23	]	]	PUNCT
admet-3091	234	24	.	.	PUNCT
admet-3091	235	1	nutropin	nutropin	ADJ
admet-3091	235	2	depot	depot	NOUN
admet-3091	235	3	®	®	NOUN
admet-3091	235	4	is	be	AUX
admet-3091	235	5	a	a	DET
admet-3091	235	6	marketed	market	VERB
admet-3091	235	7	product	product	NOUN
admet-3091	235	8	for	for	ADP
admet-3091	235	9	pediatric	pediatric	ADJ
admet-3091	235	10	growth	growth	NOUN
admet-3091	235	11	hormone	hormone	NOUN
admet-3091	235	12	deficiency	deficiency	NOUN
admet-3091	235	13	,	,	PUNCT
admet-3091	235	14	which	which	PRON
admet-3091	235	15	contains	contain	VERB
admet-3091	235	16	growth	growth	NOUN
admet-3091	235	17	hormone	hormone	NOUN
admet-3091	235	18	-	-	PUNCT
admet-3091	235	19	loaded	load	VERB
admet-3091	235	20	plga	plga	NOUN
admet-3091	235	21	microparticles	microparticle	NOUN
admet-3091	235	22	[	[	X
admet-3091	235	23	57	57	NUM
admet-3091	235	24	]	]	PUNCT
admet-3091	235	25	.	.	PUNCT
admet-3091	236	1	sandostatin	sandostatin	PROPN
admet-3091	236	2	lar	lar	ADJ
admet-3091	236	3	®	®	NOUN
admet-3091	236	4	depot	depot	NOUN
admet-3091	236	5	(	(	PUNCT
admet-3091	236	6	octreotide	octreotide	NOUN
admet-3091	236	7	acetate	acetate	NOUN
admet-3091	236	8	)	)	PUNCT
admet-3091	236	9	and	and	CCONJ
admet-3091	236	10	somatuline	somatuline	PROPN
admet-3091	236	11	®	®	PROPN
admet-3091	236	12	la	la	PROPN
admet-3091	236	13	(	(	PUNCT
admet-3091	236	14	lanreotide	lanreotide	NOUN
admet-3091	236	15	)	)	PUNCT
admet-3091	236	16	have	have	AUX
admet-3091	236	17	reached	reach	VERB
admet-3091	236	18	the	the	DET
admet-3091	236	19	market	market	NOUN
admet-3091	236	20	for	for	ADP
admet-3091	236	21	acromegaly	acromegaly	NOUN
admet-3091	236	22	therapy	therapy	NOUN
admet-3091	236	23	[	[	X
admet-3091	236	24	58	58	NUM
admet-3091	236	25	]	]	PUNCT
admet-3091	236	26	.	.	PUNCT
admet-3091	237	1	bydureon	bydureon	PROPN
admet-3091	237	2	®	®	NOUN
admet-3091	237	3	represents	represent	VERB
admet-3091	237	4	the	the	DET
admet-3091	237	5	first	first	ADJ
admet-3091	237	6	fda	fda	PROPN
admet-3091	237	7	-	-	PUNCT
admet-3091	237	8	approved	approve	VERB
admet-3091	237	9	plga	plga	NOUN
admet-3091	237	10	formulation	formulation	NOUN
admet-3091	237	11	for	for	ADP
admet-3091	237	12	glp-1	glp-1	VERB
admet-3091	237	13	receptor	receptor	NOUN
admet-3091	237	14	agonists	agonist	NOUN
admet-3091	237	15	,	,	PUNCT
admet-3091	237	16	encapsulating	encapsulate	VERB
admet-3091	237	17	exenatide	exenatide	ADV
admet-3091	237	18	in	in	ADP
admet-3091	237	19	60	60	PROPN
admet-3091	237	20	μm	μm	NUM
admet-3091	237	21	microparticles	microparticle	NOUN
admet-3091	237	22	for	for	ADP
admet-3091	237	23	sustained	sustained	ADJ
admet-3091	237	24	release	release	NOUN
admet-3091	237	25	over	over	ADP
admet-3091	237	26	7	7	NUM
admet-3091	237	27	weeks	week	NOUN
admet-3091	237	28	[	[	X
admet-3091	237	29	59	59	NUM
admet-3091	237	30	]	]	PUNCT
admet-3091	237	31	.	.	PUNCT
admet-3091	238	1	these	these	DET
admet-3091	238	2	commercial	commercial	ADJ
admet-3091	238	3	successes	success	NOUN
admet-3091	238	4	validate	validate	VERB
admet-3091	238	5	the	the	DET
admet-3091	238	6	use	use	NOUN
admet-3091	238	7	of	of	ADP
admet-3091	238	8	plga	plga	NOUN
admet-3091	238	9	-	-	PUNCT
admet-3091	238	10	based	base	VERB
admet-3091	238	11	microcarriers	microcarrier	NOUN
admet-3091	238	12	for	for	ADP
admet-3091	238	13	peptide	peptide	ADJ
admet-3091	238	14	delivery	delivery	NOUN
admet-3091	238	15	in	in	ADP
admet-3091	238	16	the	the	DET
admet-3091	238	17	treatment	treatment	NOUN
admet-3091	238	18	of	of	ADP
admet-3091	238	19	various	various	ADJ
admet-3091	238	20	diseases	disease	NOUN
admet-3091	238	21	.	.	PUNCT
admet-3091	239	1	table	table	NOUN
admet-3091	239	2	3	3	NUM
admet-3091	239	3	summarizes	summarize	VERB
admet-3091	239	4	the	the	DET
admet-3091	239	5	information	information	NOUN
admet-3091	239	6	on	on	ADP
admet-3091	239	7	these	these	DET
admet-3091	239	8	marketed	market	VERB
admet-3091	239	9	products	product	NOUN
admet-3091	239	10	.	.	PUNCT
admet-3091	240	1	as	as	SCONJ
admet-3091	240	2	shown	show	VERB
admet-3091	240	3	in	in	ADP
admet-3091	240	4	table	table	NOUN
admet-3091	240	5	3	3	NUM
admet-3091	240	6	,	,	PUNCT
admet-3091	240	7	many	many	ADJ
admet-3091	240	8	of	of	ADP
admet-3091	240	9	these	these	DET
admet-3091	240	10	products	product	NOUN
admet-3091	240	11	employ	employ	VERB
admet-3091	240	12	a	a	DET
admet-3091	240	13	range	range	NOUN
admet-3091	240	14	of	of	ADP
admet-3091	240	15	lactide	lactide	ADV
admet-3091	240	16	:	:	PUNCT
admet-3091	240	17	glycolide	glycolide	ADJ
admet-3091	240	18	ratios	ratio	NOUN
admet-3091	240	19	to	to	PART
admet-3091	240	20	modulate	modulate	VERB
admet-3091	240	21	release	release	NOUN
admet-3091	240	22	kinetics	kinetic	NOUN
admet-3091	240	23	according	accord	VERB
admet-3091	240	24	to	to	ADP
admet-3091	240	25	the	the	DET
admet-3091	240	26	application	application	NOUN
admet-3091	240	27	.	.	PUNCT
admet-3091	241	1	lower	low	ADJ
admet-3091	241	2	ratios	ratio	NOUN
admet-3091	241	3	are	be	AUX
admet-3091	241	4	used	use	VERB
admet-3091	241	5	when	when	SCONJ
admet-3091	241	6	rapid	rapid	ADJ
admet-3091	241	7	onset	onset	NOUN
admet-3091	241	8	and	and	CCONJ
admet-3091	241	9	burst	burst	ADJ
admet-3091	241	10	release	release	NOUN
admet-3091	241	11	are	be	AUX
admet-3091	241	12	favoured	favour	VERB
admet-3091	241	13	,	,	PUNCT
admet-3091	241	14	while	while	SCONJ
admet-3091	241	15	higher	high	ADJ
admet-3091	241	16	ratios	ratio	NOUN
admet-3091	241	17	are	be	AUX
admet-3091	241	18	preferred	prefer	VERB
admet-3091	241	19	for	for	ADP
admet-3091	241	20	sustained	sustained	ADJ
admet-3091	241	21	release	release	NOUN
admet-3091	241	22	and	and	CCONJ
admet-3091	241	23	reduced	reduce	VERB
admet-3091	241	24	dosing	dose	VERB
admet-3091	241	25	frequency	frequency	NOUN
admet-3091	241	26	.	.	PUNCT
admet-3091	242	1	table	table	NOUN
admet-3091	242	2	3	3	NUM
admet-3091	242	3	.	.	PUNCT
admet-3091	242	4	marketed	market	VERB
admet-3091	242	5	plga	plga	NOUN
admet-3091	242	6	-	-	PUNCT
admet-3091	242	7	based	base	VERB
admet-3091	242	8	products	product	NOUN
admet-3091	242	9	for	for	ADP
admet-3091	242	10	peptide	peptide	ADJ
admet-3091	242	11	delivery	delivery	NOUN
admet-3091	242	12	product	product	NOUN
admet-3091	242	13	name	name	VERB
admet-3091	242	14	active	active	ADJ
admet-3091	242	15	ingredient	ingredient	NOUN
admet-3091	242	16	formulation	formulation	NOUN
admet-3091	242	17	manufacturing	manufacturing	NOUN
admet-3091	242	18	technique	technique	NOUN
admet-3091	242	19	fda	fda	PROPN
admet-3091	242	20	approval	approval	NOUN
admet-3091	242	21	date	date	NOUN
admet-3091	242	22	disease	disease	NOUN
admet-3091	242	23	lupron	lupron	NOUN
admet-3091	242	24	depot	depot	NOUN
admet-3091	242	25	®	®	NOUN
admet-3091	242	26	leuprolide	leuprolide	NOUN
admet-3091	242	27	acetate	acetate	NOUN
admet-3091	242	28	plga	plga	NOUN
admet-3091	242	29	(	(	PUNCT
admet-3091	242	30	75:25	75:25	NUM
admet-3091	242	31	)	)	PUNCT
admet-3091	242	32	microparticle	microparticle	NOUN
admet-3091	242	33	(	(	PUNCT
admet-3091	242	34	10	10	NUM
admet-3091	242	35	-	-	SYM
admet-3091	242	36	30	30	NUM
admet-3091	242	37	µm	µm	NOUN
admet-3091	242	38	)	)	PUNCT
admet-3091	242	39	double	double	ADJ
admet-3091	242	40	emulsion	emulsion	NOUN
admet-3091	242	41	1989	1989	NUM
admet-3091	242	42	prostate	prostate	NOUN
admet-3091	242	43	cancer	cancer	NOUN
admet-3091	242	44	suprecur	suprecur	NOUN
admet-3091	242	45	®	®	NOUN
admet-3091	242	46	mp	mp	PROPN
admet-3091	242	47	buserelin	buserelin	PROPN
admet-3091	242	48	acetate	acetate	PROPN
admet-3091	242	49	plga	plga	NOUN
admet-3091	242	50	(	(	PUNCT
admet-3091	242	51	50:50	50:50	NUM
admet-3091	242	52	)	)	PUNCT
admet-3091	242	53	microparticle	microparticle	NOUN
admet-3091	242	54	(	(	PUNCT
admet-3091	242	55	<	<	X
admet-3091	242	56	200	200	NUM
admet-3091	242	57	µm	µm	NOUN
admet-3091	242	58	)	)	PUNCT
admet-3091	242	59	spray	spray	NOUN
admet-3091	242	60	drying	dry	VERB
admet-3091	242	61	not	not	PART
admet-3091	242	62	approved	approve	VERB
admet-3091	242	63	by	by	ADP
admet-3091	242	64	fda	fda	PROPN
admet-3091	242	65	prostate	prostate	NOUN
admet-3091	242	66	cancer	cancer	NOUN
admet-3091	242	67	decapeptyl	decapeptyl	PROPN
admet-3091	242	68	®	®	PROPN
admet-3091	242	69	triptorelin	triptorelin	PROPN
admet-3091	242	70	pamoate	pamoate	ADJ
admet-3091	242	71	plga	plga	NOUN
admet-3091	242	72	(	(	PUNCT
admet-3091	242	73	75:25	75:25	NUM
admet-3091	242	74	,	,	PUNCT
admet-3091	242	75	85:15	85:15	NUM
admet-3091	242	76	,	,	PUNCT
admet-3091	242	77	90:10	90:10	NUM
admet-3091	242	78	,	,	PUNCT
admet-3091	242	79	95:5	95:5	NUM
admet-3091	242	80	)	)	PUNCT
admet-3091	242	81	microparticle	microparticle	NOUN
admet-3091	242	82	(	(	PUNCT
admet-3091	242	83	10	10	NUM
admet-3091	242	84	to	to	PART
admet-3091	242	85	110	110	NUM
admet-3091	242	86	µm	µm	NOUN
admet-3091	242	87	)	)	PUNCT
admet-3091	242	88	double	double	ADJ
admet-3091	242	89	emulsion	emulsion	NOUN
admet-3091	242	90	,	,	PUNCT
admet-3091	242	91	solvent	solvent	NOUN
admet-3091	242	92	-	-	PUNCT
admet-3091	242	93	free	free	ADJ
admet-3091	242	94	microgranule	microgranule	NOUN
admet-3091	242	95	process	process	NOUN
admet-3091	242	96	,	,	PUNCT
admet-3091	242	97	premix	premix	NOUN
admet-3091	242	98	membrane	membrane	NOUN
admet-3091	242	99	emulsification	emulsification	NOUN
admet-3091	242	100	not	not	PART
admet-3091	242	101	approved	approve	VERB
admet-3091	242	102	by	by	ADP
admet-3091	242	103	fda	fda	PROPN
admet-3091	242	104	prostate	prostate	NOUN
admet-3091	242	105	cancer	cancer	NOUN
admet-3091	242	106	trelstar	trelstar	NOUN
admet-3091	242	107	™	™	PROPN
admet-3091	242	108	depot	depot	NOUN
admet-3091	242	109	triptorelin	triptorelin	NOUN
admet-3091	242	110	pamoate	pamoate	ADJ
admet-3091	242	111	plga	plga	NOUN
admet-3091	242	112	(	(	PUNCT
admet-3091	242	113	74:26	74:26	NUM
admet-3091	242	114	,	,	PUNCT
admet-3091	242	115	77:23	77:23	NUM
admet-3091	242	116	,	,	PUNCT
admet-3091	242	117	52:48	52:48	NUM
admet-3091	242	118	)	)	PUNCT
admet-3091	242	119	microparticle	microparticle	NOUN
admet-3091	242	120	(	(	PUNCT
admet-3091	242	121	<	<	X
admet-3091	242	122	250	250	NUM
admet-3091	242	123	µm	µm	NOUN
admet-3091	242	124	)	)	PUNCT
admet-3091	242	125	solvent	solvent	NOUN
admet-3091	242	126	-	-	PUNCT
admet-3091	242	127	free	free	ADJ
admet-3091	242	128	microgranule	microgranule	NOUN
admet-3091	242	129	process	process	NOUN
admet-3091	242	130	2000	2000	NUM
admet-3091	242	131	prostate	prostate	NOUN
admet-3091	242	132	cancer	cancer	NOUN
admet-3091	242	133	nutropin	nutropin	NOUN
admet-3091	242	134	depot	depot	NOUN
admet-3091	242	135	®	®	NOUN
admet-3091	242	136	somatropin	somatropin	NOUN
admet-3091	242	137	plga	plga	NOUN
admet-3091	242	138	(	(	PUNCT
admet-3091	242	139	50:50	50:50	NUM
admet-3091	242	140	)	)	PUNCT
admet-3091	242	141	microparticle	microparticle	NOUN
admet-3091	242	142	prolease	prolease	NOUN
admet-3091	242	143	cryogenic	cryogenic	NOUN
admet-3091	242	144	process	process	NOUN
admet-3091	242	145	1999	1999	NUM
admet-3091	242	146	pediatric	pediatric	ADJ
admet-3091	242	147	growth	growth	NOUN
admet-3091	242	148	hormone	hormone	NOUN
admet-3091	242	149	deficiency	deficiency	NOUN
admet-3091	242	150	sandostatin	sandostatin	PROPN
admet-3091	242	151	lar	lar	ADJ
admet-3091	242	152	®	®	PROPN
admet-3091	242	153	depot	depot	NOUN
admet-3091	242	154	octreotide	octreotide	NOUN
admet-3091	242	155	acetate	acetate	NOUN
admet-3091	242	156	plga	plga	NOUN
admet-3091	242	157	(	(	PUNCT
admet-3091	242	158	55:45	55:45	NUM
admet-3091	242	159	)	)	PUNCT
admet-3091	242	160	microparticle	microparticle	NOUN
admet-3091	242	161	(	(	PUNCT
admet-3091	242	162	30	30	NUM
admet-3091	242	163	to	to	PART
admet-3091	242	164	100	100	NUM
admet-3091	242	165	µm	µm	NOUN
admet-3091	242	166	)	)	PUNCT
admet-3091	242	167	precipitation	precipitation	NOUN
admet-3091	242	168	1998	1998	NUM
admet-3091	242	169	acromegaly	acromegaly	PROPN
admet-3091	242	170	somatuline	somatuline	PROPN
admet-3091	242	171	®	®	PROPN
admet-3091	242	172	la	la	PRON
admet-3091	242	173	lanreotide	lanreotide	NOUN
admet-3091	242	174	plga	plga	NOUN
admet-3091	242	175	(	(	PUNCT
admet-3091	242	176	75:25	75:25	NUM
admet-3091	242	177	,	,	PUNCT
admet-3091	242	178	50:50	50:50	NUM
admet-3091	242	179	)	)	PUNCT
admet-3091	242	180	microparticle	microparticle	NOUN
admet-3091	242	181	(	(	PUNCT
admet-3091	242	182	20	20	NUM
admet-3091	242	183	to	to	PART
admet-3091	242	184	100	100	NUM
admet-3091	242	185	µm	µm	NOUN
admet-3091	242	186	)	)	PUNCT
admet-3091	242	187	double	double	ADJ
admet-3091	242	188	emulsion	emulsion	NOUN
admet-3091	242	189	2007	2007	NUM
admet-3091	242	190	acromegaly	acromegaly	PROPN
admet-3091	242	191	bydureon	bydureon	PROPN
admet-3091	242	192	®	®	PROPN
admet-3091	242	193	exenatide	exenatide	NOUN
admet-3091	242	194	plga	plga	NOUN
admet-3091	242	195	(	(	PUNCT
admet-3091	242	196	50:50	50:50	NUM
admet-3091	242	197	)	)	PUNCT
admet-3091	242	198	microparticle	microparticle	NOUN
admet-3091	242	199	(	(	PUNCT
admet-3091	242	200	median	median	NOUN
admet-3091	242	201	:	:	PUNCT
admet-3091	242	202	55	55	NUM
admet-3091	242	203	µm	µm	NOUN
admet-3091	242	204	)	)	PUNCT
admet-3091	242	205	precipitation	precipitation	NOUN
admet-3091	242	206	2012	2012	NUM
admet-3091	242	207	diabetes	diabetes	NOUN
admet-3091	242	208	currently	currently	ADV
admet-3091	242	209	,	,	PUNCT
admet-3091	242	210	no	no	DET
admet-3091	242	211	marketed	market	VERB
admet-3091	242	212	products	product	NOUN
admet-3091	242	213	based	base	VERB
admet-3091	242	214	on	on	ADP
admet-3091	242	215	plga	plga	NOUN
admet-3091	242	216	nanoparticles	nanoparticle	NOUN
admet-3091	242	217	for	for	ADP
admet-3091	242	218	peptide	peptide	ADJ
admet-3091	242	219	delivery	delivery	NOUN
admet-3091	242	220	are	be	AUX
admet-3091	242	221	available	available	ADJ
admet-3091	242	222	.	.	PUNCT
admet-3091	243	1	manufacturing	manufacture	VERB
admet-3091	243	2	complications	complication	NOUN
admet-3091	243	3	and	and	CCONJ
admet-3091	243	4	regulatory	regulatory	ADJ
admet-3091	243	5	issues	issue	NOUN
admet-3091	243	6	have	have	AUX
admet-3091	243	7	prevented	prevent	VERB
admet-3091	243	8	plga	plga	NOUN
admet-3091	243	9	nanoparticles	nanoparticle	NOUN
admet-3091	243	10	from	from	ADP
admet-3091	243	11	entering	enter	VERB
admet-3091	243	12	the	the	DET
admet-3091	243	13	pharmaceutical	pharmaceutical	ADJ
admet-3091	243	14	peptide	peptide	NOUN
admet-3091	243	15	market	market	NOUN
admet-3091	243	16	.	.	PUNCT
admet-3091	244	1	there	there	PRON
admet-3091	244	2	is	be	VERB
admet-3091	244	3	a	a	DET
admet-3091	244	4	lack	lack	NOUN
admet-3091	244	5	of	of	ADP
admet-3091	244	6	robust	robust	ADJ
admet-3091	244	7	manufacturing	manufacturing	NOUN
admet-3091	244	8	methods	method	NOUN
admet-3091	244	9	for	for	ADP
admet-3091	244	10	plga	plga	NOUN
admet-3091	244	11	nanoparticles	nanoparticle	NOUN
admet-3091	244	12	at	at	ADP
admet-3091	244	13	the	the	DET
admet-3091	244	14	industrial	industrial	ADJ
admet-3091	244	15	scale	scale	NOUN
admet-3091	244	16	,	,	PUNCT
admet-3091	244	17	as	as	ADV
admet-3091	244	18	well	well	ADV
admet-3091	244	19	as	as	ADP
admet-3091	244	20	limitations	limitation	NOUN
admet-3091	244	21	in	in	ADP
admet-3091	244	22	analytical	analytical	ADJ
admet-3091	244	23	methods	method	NOUN
admet-3091	244	24	for	for	ADP
admet-3091	244	25	characterization	characterization	NOUN
admet-3091	244	26	and	and	CCONJ
admet-3091	244	27	quality	quality	NOUN
admet-3091	244	28	control	control	NOUN
admet-3091	244	29	.	.	PUNCT
admet-3091	245	1	an	an	DET
admet-3091	245	2	absence	absence	NOUN
admet-3091	245	3	of	of	ADP
admet-3091	245	4	established	establish	VERB
admet-3091	245	5	regulatory	regulatory	ADJ
admet-3091	245	6	pathways	pathway	NOUN
admet-3091	245	7	for	for	ADP
admet-3091	245	8	plga	plga	NOUN
admet-3091	245	9	nanomedicines	nanomedicine	NOUN
admet-3091	245	10	further	far	ADV
admet-3091	245	11	complicates	complicate	VERB
admet-3091	245	12	marketing	marketing	NOUN
admet-3091	245	13	of	of	ADP
admet-3091	245	14	plga	plga	NOUN
admet-3091	245	15	nanoparticlebased	nanoparticlebase	VERB
admet-3091	245	16	peptide	peptide	NOUN
admet-3091	245	17	drugs	drug	NOUN
admet-3091	245	18	[	[	X
admet-3091	245	19	60	60	NUM
admet-3091	245	20	]	]	PUNCT
admet-3091	245	21	.	.	PUNCT
admet-3091	246	1	marketed	market	VERB
admet-3091	246	2	plga	plga	NOUN
admet-3091	246	3	-	-	PUNCT
admet-3091	246	4	based	base	VERB
admet-3091	246	5	products	product	NOUN
admet-3091	246	6	for	for	ADP
admet-3091	246	7	peptide	peptide	ADJ
admet-3091	246	8	delivery	delivery	NOUN
admet-3091	246	9	are	be	AUX
admet-3091	246	10	shown	show	VERB
admet-3091	246	11	in	in	ADP
admet-3091	246	12	table	table	NOUN
admet-3091	246	13	3	3	NUM
admet-3091	246	14	.	.	PUNCT
admet-3091	246	15	conclusion	conclusion	NOUN
admet-3091	246	16	plga	plga	VERB
admet-3091	246	17	nanoparticles	nanoparticle	NOUN
admet-3091	246	18	and	and	CCONJ
admet-3091	246	19	microparticles	microparticle	NOUN
admet-3091	246	20	represent	represent	VERB
admet-3091	246	21	highly	highly	ADV
admet-3091	246	22	versatile	versatile	ADJ
admet-3091	246	23	and	and	CCONJ
admet-3091	246	24	clinically	clinically	ADV
admet-3091	246	25	validated	validate	VERB
admet-3091	246	26	platforms	platform	NOUN
admet-3091	246	27	for	for	ADP
admet-3091	246	28	delivering	deliver	VERB
admet-3091	246	29	therapeutic	therapeutic	ADJ
admet-3091	246	30	peptides	peptide	NOUN
admet-3091	246	31	,	,	PUNCT
admet-3091	246	32	which	which	PRON
admet-3091	246	33	are	be	AUX
admet-3091	246	34	often	often	ADV
admet-3091	246	35	characterized	characterize	VERB
admet-3091	246	36	by	by	ADP
admet-3091	246	37	poor	poor	ADJ
admet-3091	246	38	stability	stability	NOUN
admet-3091	246	39	,	,	PUNCT
admet-3091	246	40	rapid	rapid	ADJ
admet-3091	246	41	degradation	degradation	NOUN
admet-3091	246	42	,	,	PUNCT
admet-3091	246	43	and	and	CCONJ
admet-3091	246	44	short	short	ADJ
admet-3091	246	45	biological	biological	ADJ
admet-3091	246	46	half	half	ADJ
admet-3091	246	47	-	-	PUNCT
admet-3091	246	48	lives	life	NOUN
admet-3091	246	49	.	.	PUNCT
admet-3091	247	1	these	these	DET
admet-3091	247	2	biodegradable	biodegradable	ADJ
admet-3091	247	3	carriers	carrier	NOUN
admet-3091	247	4	offer	offer	VERB
admet-3091	247	5	tenable	tenable	ADJ
admet-3091	247	6	and	and	CCONJ
admet-3091	247	7	sustained	sustained	ADJ
admet-3091	247	8	release	release	NOUN
admet-3091	247	9	profiles	profile	NOUN
admet-3091	247	10	through	through	ADP
admet-3091	247	11	the	the	DET
admet-3091	247	12	careful	careful	ADJ
admet-3091	247	13	selection	selection	NOUN
admet-3091	247	14	and	and	CCONJ
admet-3091	247	15	manipulation	manipulation	NOUN
admet-3091	247	16	of	of	ADP
admet-3091	247	17	polymer	polymer	NOUN
admet-3091	247	18	composition	composition	NOUN
admet-3091	247	19	(	(	PUNCT
admet-3091	247	20	e.g.	e.g.	ADV
admet-3091	247	21	lactic	lactic	ADJ
admet-3091	247	22	/	/	SYM
admet-3091	247	23	glycolic	glycolic	NOUN
admet-3091	247	24	acid	acid	NOUN
admet-3091	247	25	ratio	ratio	NOUN
admet-3091	247	26	and	and	CCONJ
admet-3091	247	27	molecular	molecular	ADJ
admet-3091	247	28	weight	weight	NOUN
admet-3091	247	29	)	)	PUNCT
admet-3091	247	30	,	,	PUNCT
admet-3091	247	31	surface	surface	NOUN
admet-3091	247	32	properties	property	NOUN
admet-3091	247	33	,	,	PUNCT
admet-3091	247	34	particle	particle	NOUN
admet-3091	247	35	size	size	NOUN
admet-3091	247	36	,	,	PUNCT
admet-3091	247	37	and	and	CCONJ
admet-3091	247	38	formulation	formulation	NOUN
admet-3091	247	39	techniques	technique	NOUN
admet-3091	247	40	such	such	ADJ
admet-3091	247	41	as	as	ADP
admet-3091	247	42	singleor	singleor	NOUN
admet-3091	247	43	double	double	ADJ
admet-3091	247	44	-	-	PUNCT
admet-3091	247	45	emulsion	emulsion	NOUN
admet-3091	247	46	,	,	PUNCT
admet-3091	247	47	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	247	48	,	,	PUNCT
admet-3091	247	49	or	or	CCONJ
admet-3091	247	50	spray	spray	NOUN
admet-3091	247	51	-	-	PUNCT
admet-3091	247	52	drying	dry	VERB
admet-3091	247	53	.	.	PUNCT
admet-3091	248	1	by	by	ADP
admet-3091	248	2	adjusting	adjust	VERB
admet-3091	248	3	these	these	DET
admet-3091	248	4	parameters	parameter	NOUN
admet-3091	248	5	,	,	PUNCT
admet-3091	248	6	it	it	PRON
admet-3091	248	7	is	be	AUX
admet-3091	248	8	possible	possible	ADJ
admet-3091	248	9	to	to	PART
admet-3091	248	10	modulate	modulate	VERB
admet-3091	248	11	release	release	NOUN
admet-3091	248	12	kinetics	kinetic	NOUN
admet-3091	248	13	to	to	PART
admet-3091	248	14	match	match	VERB
admet-3091	248	15	admet	admet	PROPN
admet-3091	248	16	&	&	CCONJ
admet-3091	248	17	dmpk	dmpk	PROPN
admet-3091	248	18	00(0	00(0	PROPN
admet-3091	248	19	)	)	PUNCT
admet-3091	248	20	(	(	PUNCT
admet-3091	248	21	2025	2025	NUM
admet-3091	248	22	)	)	PUNCT
admet-3091	248	23	3091	3091	NUM
admet-3091	248	24	plga	plga	NOUN
admet-3091	248	25	nanoparticles	nanoparticle	NOUN
admet-3091	248	26	and	and	CCONJ
admet-3091	248	27	microparticles	microparticle	NOUN
admet-3091	248	28	for	for	ADP
admet-3091	248	29	peptide	peptide	ADJ
admet-3091	248	30	delivery	delivery	NOUN
admet-3091	248	31	doi	doi	NOUN
admet-3091	248	32	:	:	PUNCT
admet-3091	248	33	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	X
admet-3091	248	34	13	13	NUM
admet-3091	248	35	therapeutic	therapeutic	ADJ
admet-3091	248	36	needs	need	NOUN
admet-3091	248	37	,	,	PUNCT
admet-3091	248	38	ranging	range	VERB
admet-3091	248	39	from	from	ADP
admet-3091	248	40	rapid	rapid	ADJ
admet-3091	248	41	initial	initial	ADJ
admet-3091	248	42	release	release	NOUN
admet-3091	248	43	to	to	ADP
admet-3091	248	44	long	long	ADJ
admet-3091	248	45	-	-	PUNCT
admet-3091	248	46	term	term	NOUN
admet-3091	248	47	depot	depot	NOUN
admet-3091	248	48	formulations	formulation	NOUN
admet-3091	248	49	that	that	PRON
admet-3091	248	50	last	last	ADJ
admet-3091	248	51	days	day	NOUN
admet-3091	248	52	or	or	CCONJ
admet-3091	248	53	even	even	ADV
admet-3091	248	54	weeks	week	NOUN
admet-3091	248	55	.	.	PUNCT
admet-3091	249	1	a	a	DET
admet-3091	249	2	deep	deep	ADJ
admet-3091	249	3	understanding	understanding	NOUN
admet-3091	249	4	of	of	ADP
admet-3091	249	5	the	the	DET
admet-3091	249	6	interplay	interplay	NOUN
admet-3091	249	7	between	between	ADP
admet-3091	249	8	diffusion	diffusion	NOUN
admet-3091	249	9	,	,	PUNCT
admet-3091	249	10	polymer	polymer	NOUN
admet-3091	249	11	erosion	erosion	NOUN
admet-3091	249	12	,	,	PUNCT
admet-3091	249	13	and	and	CCONJ
admet-3091	249	14	swelling	swelling	NOUN
admet-3091	249	15	enables	enable	VERB
admet-3091	249	16	the	the	DET
admet-3091	249	17	rational	rational	ADJ
admet-3091	249	18	design	design	NOUN
admet-3091	249	19	of	of	ADP
admet-3091	249	20	delivery	delivery	NOUN
admet-3091	249	21	systems	system	NOUN
admet-3091	249	22	that	that	PRON
admet-3091	249	23	ensure	ensure	VERB
admet-3091	249	24	controlled	control	VERB
admet-3091	249	25	release	release	NOUN
admet-3091	249	26	while	while	SCONJ
admet-3091	249	27	minimizing	minimize	VERB
admet-3091	249	28	peptide	peptide	NOUN
admet-3091	249	29	denaturation	denaturation	NOUN
admet-3091	249	30	or	or	CCONJ
admet-3091	249	31	aggregation	aggregation	NOUN
admet-3091	249	32	.	.	PUNCT
admet-3091	250	1	moreover	moreover	ADV
admet-3091	250	2	,	,	PUNCT
admet-3091	250	3	plga	plga	VERB
admet-3091	250	4	particles	particle	NOUN
admet-3091	250	5	can	can	AUX
admet-3091	250	6	protect	protect	VERB
admet-3091	250	7	sensitive	sensitive	ADJ
admet-3091	250	8	peptides	peptide	NOUN
admet-3091	250	9	from	from	ADP
admet-3091	250	10	enzymatic	enzymatic	ADJ
admet-3091	250	11	degradation	degradation	NOUN
admet-3091	250	12	in	in	ADP
admet-3091	250	13	the	the	DET
admet-3091	250	14	gastrointestinal	gastrointestinal	ADJ
admet-3091	250	15	tract	tract	NOUN
admet-3091	250	16	or	or	CCONJ
admet-3091	250	17	in	in	ADP
admet-3091	250	18	the	the	DET
admet-3091	250	19	systemic	systemic	ADJ
admet-3091	250	20	circulation	circulation	NOUN
admet-3091	250	21	,	,	PUNCT
admet-3091	250	22	thereby	thereby	ADV
admet-3091	250	23	enhancing	enhance	VERB
admet-3091	250	24	their	their	PRON
admet-3091	250	25	bioavailability	bioavailability	NOUN
admet-3091	250	26	and	and	CCONJ
admet-3091	250	27	efficacy	efficacy	NOUN
admet-3091	250	28	.	.	PUNCT
admet-3091	251	1	despite	despite	SCONJ
admet-3091	251	2	these	these	DET
admet-3091	251	3	advantages	advantage	NOUN
admet-3091	251	4	,	,	PUNCT
admet-3091	251	5	challenges	challenge	NOUN
admet-3091	251	6	persist	persist	VERB
admet-3091	251	7	,	,	PUNCT
admet-3091	251	8	including	include	VERB
admet-3091	251	9	incomplete	incomplete	ADJ
admet-3091	251	10	release	release	NOUN
admet-3091	251	11	,	,	PUNCT
admet-3091	251	12	unpredictable	unpredictable	ADJ
admet-3091	251	13	in	in	ADP
admet-3091	251	14	vitro	vitro	X
admet-3091	251	15	in	in	ADP
admet-3091	251	16	vivo	vivo	ADJ
admet-3091	251	17	correlation	correlation	NOUN
admet-3091	251	18	,	,	PUNCT
admet-3091	251	19	and	and	CCONJ
admet-3091	251	20	the	the	DET
admet-3091	251	21	risk	risk	NOUN
admet-3091	251	22	of	of	ADP
admet-3091	251	23	peptide	peptide	ADJ
admet-3091	251	24	acylation	acylation	NOUN
admet-3091	251	25	during	during	ADP
admet-3091	251	26	formulation	formulation	NOUN
admet-3091	251	27	.	.	PUNCT
admet-3091	252	1	however	however	ADV
admet-3091	252	2	,	,	PUNCT
admet-3091	252	3	advances	advance	NOUN
admet-3091	252	4	in	in	ADP
admet-3091	252	5	polymer	polymer	NOUN
admet-3091	252	6	chemistry	chemistry	NOUN
admet-3091	252	7	,	,	PUNCT
admet-3091	252	8	peptide	peptide	ADJ
admet-3091	252	9	stabilization	stabilization	NOUN
admet-3091	252	10	strategies	strategy	NOUN
admet-3091	252	11	(	(	PUNCT
admet-3091	252	12	e.g.	e.g.	ADV
admet-3091	252	13	pegylation	pegylation	NOUN
admet-3091	252	14	,	,	PUNCT
admet-3091	252	15	ph	ph	ADJ
admet-3091	252	16	modulation	modulation	NOUN
admet-3091	252	17	)	)	PUNCT
admet-3091	252	18	,	,	PUNCT
admet-3091	252	19	and	and	CCONJ
admet-3091	252	20	scalable	scalable	ADJ
admet-3091	252	21	manufacturing	manufacturing	NOUN
admet-3091	252	22	techniques	technique	NOUN
admet-3091	252	23	are	be	AUX
admet-3091	252	24	steadily	steadily	ADV
admet-3091	252	25	overcoming	overcome	VERB
admet-3091	252	26	these	these	DET
admet-3091	252	27	limitations	limitation	NOUN
admet-3091	252	28	.	.	PUNCT
admet-3091	253	1	the	the	DET
admet-3091	253	2	clinical	clinical	ADJ
admet-3091	253	3	success	success	NOUN
admet-3091	253	4	of	of	ADP
admet-3091	253	5	plga	plga	NOUN
admet-3091	253	6	-	-	PUNCT
admet-3091	253	7	based	base	VERB
admet-3091	253	8	peptide	peptide	NOUN
admet-3091	253	9	formulations	formulation	NOUN
admet-3091	253	10	,	,	PUNCT
admet-3091	253	11	such	such	ADJ
admet-3091	253	12	as	as	ADP
admet-3091	253	13	lupron	lupron	NOUN
admet-3091	253	14	depot	depot	NOUN
admet-3091	253	15	®	®	NOUN
admet-3091	253	16	and	and	CCONJ
admet-3091	253	17	sandostatin	sandostatin	PROPN
admet-3091	253	18	lar	lar	PROPN
admet-3091	253	19	®	®	PROPN
admet-3091	253	20	,	,	PUNCT
admet-3091	253	21	demonstrates	demonstrate	VERB
admet-3091	253	22	the	the	DET
admet-3091	253	23	viability	viability	NOUN
admet-3091	253	24	of	of	ADP
admet-3091	253	25	this	this	DET
admet-3091	253	26	technology	technology	NOUN
admet-3091	253	27	in	in	ADP
admet-3091	253	28	achieving	achieve	VERB
admet-3091	253	29	effective	effective	ADJ
admet-3091	253	30	,	,	PUNCT
admet-3091	253	31	patient	patient	NOUN
admet-3091	253	32	-	-	PUNCT
admet-3091	253	33	friendly	friendly	ADJ
admet-3091	253	34	,	,	PUNCT
admet-3091	253	35	and	and	CCONJ
admet-3091	253	36	commercially	commercially	ADV
admet-3091	253	37	successful	successful	ADJ
admet-3091	253	38	long	long	ADV
admet-3091	253	39	-	-	PUNCT
admet-3091	253	40	acting	act	VERB
admet-3091	253	41	release	release	NOUN
admet-3091	253	42	systems	system	NOUN
admet-3091	253	43	.	.	PUNCT
admet-3091	254	1	these	these	DET
admet-3091	254	2	achievements	achievement	NOUN
admet-3091	254	3	provide	provide	VERB
admet-3091	254	4	a	a	DET
admet-3091	254	5	robust	robust	ADJ
admet-3091	254	6	foundation	foundation	NOUN
admet-3091	254	7	for	for	ADP
admet-3091	254	8	the	the	DET
admet-3091	254	9	development	development	NOUN
admet-3091	254	10	of	of	ADP
admet-3091	254	11	next	next	ADJ
admet-3091	254	12	-	-	PUNCT
admet-3091	254	13	generation	generation	NOUN
admet-3091	254	14	plga	plga	NOUN
admet-3091	254	15	-	-	PUNCT
admet-3091	254	16	based	base	VERB
admet-3091	254	17	platforms	platform	NOUN
admet-3091	254	18	tailored	tailor	VERB
admet-3091	254	19	to	to	ADP
admet-3091	254	20	emerging	emerge	VERB
admet-3091	254	21	peptide	peptide	ADJ
admet-3091	254	22	therapeutics	therapeutic	NOUN
admet-3091	254	23	,	,	PUNCT
admet-3091	254	24	particularly	particularly	ADV
admet-3091	254	25	in	in	ADP
admet-3091	254	26	oncology	oncology	NOUN
admet-3091	254	27	,	,	PUNCT
admet-3091	254	28	endocrinology	endocrinology	NOUN
admet-3091	254	29	,	,	PUNCT
admet-3091	254	30	and	and	CCONJ
admet-3091	254	31	metabolic	metabolic	NOUN
admet-3091	254	32	disorders	disorder	NOUN
admet-3091	254	33	.	.	PUNCT
admet-3091	255	1	funding	funding	NOUN
admet-3091	255	2	:	:	PUNCT
admet-3091	255	3	the	the	DET
admet-3091	255	4	authors	author	NOUN
admet-3091	255	5	received	receive	VERB
admet-3091	255	6	no	no	DET
admet-3091	255	7	funding	funding	NOUN
admet-3091	255	8	for	for	ADP
admet-3091	255	9	this	this	DET
admet-3091	255	10	research	research	NOUN
admet-3091	255	11	.	.	PUNCT
admet-3091	256	1	acknowledgements	acknowledgement	NOUN
admet-3091	256	2	:	:	PUNCT
admet-3091	256	3	thanks	thank	NOUN
admet-3091	256	4	to	to	ADP
admet-3091	256	5	the	the	DET
admet-3091	256	6	guidance	guidance	NOUN
admet-3091	256	7	and	and	CCONJ
admet-3091	256	8	advice	advice	NOUN
admet-3091	256	9	from	from	ADP
admet-3091	256	10	the	the	DET
admet-3091	256	11	"	"	PUNCT
admet-3091	256	12	clinical	clinical	ADJ
admet-3091	256	13	research	research	NOUN
admet-3091	256	14	development	development	NOUN
admet-3091	256	15	unit	unit	NOUN
admet-3091	256	16	of	of	ADP
admet-3091	256	17	baqiyatallah	baqiyatallah	NOUN
admet-3091	256	18	hospital	hospital	NOUN
admet-3091	256	19	"	"	PUNCT
admet-3091	256	20	.	.	PUNCT
admet-3091	257	1	we	we	PRON
admet-3091	257	2	would	would	AUX
admet-3091	257	3	like	like	VERB
admet-3091	257	4	to	to	PART
admet-3091	257	5	thank	thank	VERB
admet-3091	257	6	the	the	DET
admet-3091	257	7	guidance	guidance	NOUN
admet-3091	257	8	and	and	CCONJ
admet-3091	257	9	support	support	NOUN
admet-3091	257	10	from	from	ADP
admet-3091	257	11	the	the	DET
admet-3091	257	12	research	research	NOUN
admet-3091	257	13	and	and	CCONJ
admet-3091	257	14	technology	technology	NOUN
admet-3091	257	15	comprehensive	comprehensive	ADJ
admet-3091	257	16	laboratory	laboratory	NOUN
admet-3091	257	17	(	(	PUNCT
admet-3091	257	18	rtcl	rtcl	NOUN
admet-3091	257	19	)	)	PUNCT
admet-3091	257	20	of	of	ADP
admet-3091	257	21	baqiyatallah	baqiyatallah	PROPN
admet-3091	257	22	university	university	PROPN
admet-3091	257	23	of	of	ADP
admet-3091	257	24	medical	medical	ADJ
admet-3091	257	25	sciences	science	NOUN
admet-3091	257	26	.	.	PUNCT
admet-3091	258	1	conflict	conflict	NOUN
admet-3091	258	2	of	of	ADP
admet-3091	258	3	interest	interest	NOUN
admet-3091	258	4	:	:	PUNCT
admet-3091	258	5	the	the	DET
admet-3091	258	6	authors	author	NOUN
admet-3091	258	7	declare	declare	VERB
admet-3091	258	8	no	no	DET
admet-3091	258	9	conflict	conflict	NOUN
admet-3091	258	10	of	of	ADP
admet-3091	258	11	interest	interest	NOUN
admet-3091	258	12	author	author	NOUN
admet-3091	258	13	contributions	contribution	NOUN
admet-3091	258	14	:	:	PUNCT
admet-3091	258	15	mohammadmahdi	mohammadmahdi	PROPN
admet-3091	258	16	eshaghi	eshaghi	PROPN
admet-3091	258	17	:	:	PUNCT
admet-3091	258	18	conceptualization	conceptualization	NOUN
admet-3091	258	19	,	,	PUNCT
admet-3091	258	20	data	data	NOUN
admet-3091	258	21	curation	curation	NOUN
admet-3091	258	22	,	,	PUNCT
admet-3091	258	23	writing	write	VERB
admet-3091	258	24	original	original	ADJ
admet-3091	258	25	draft	draft	NOUN
admet-3091	258	26	;	;	PUNCT
admet-3091	258	27	marzieh	marzieh	PROPN
admet-3091	258	28	dehghani	dehghani	PROPN
admet-3091	258	29	:	:	PUNCT
admet-3091	258	30	supervision	supervision	NOUN
admet-3091	258	31	,	,	PUNCT
admet-3091	258	32	writing	writing	NOUN
admet-3091	258	33	,	,	PUNCT
admet-3091	258	34	review	review	NOUN
admet-3091	258	35	and	and	CCONJ
admet-3091	258	36	editing	editing	NOUN
admet-3091	258	37	;	;	PUNCT
admet-3091	258	38	azam	azam	PROPN
admet-3091	258	39	abedi	abedi	PROPN
admet-3091	258	40	:	:	PUNCT
admet-3091	258	41	visualization	visualization	NOUN
admet-3091	258	42	,	,	PUNCT
admet-3091	258	43	software	software	NOUN
admet-3091	258	44	;	;	PUNCT
admet-3091	258	45	mehrdad	mehrdad	NOUN
admet-3091	258	46	moosazadeh	moosazadeh	NOUN
admet-3091	258	47	moghaddam	moghaddam	NOUN
admet-3091	258	48	:	:	PUNCT
admet-3091	258	49	supervision	supervision	NOUN
admet-3091	258	50	,	,	PUNCT
admet-3091	258	51	writing	writing	NOUN
admet-3091	258	52	,	,	PUNCT
admet-3091	258	53	review	review	NOUN
admet-3091	258	54	and	and	CCONJ
admet-3091	258	55	editing	editing	NOUN
admet-3091	258	56	;	;	PUNCT
admet-3091	258	57	ramezan	ramezan	PROPN
admet-3091	258	58	ali	ali	PROPN
admet-3091	258	59	taheri	taheri	PROPN
admet-3091	258	60	:	:	PUNCT
admet-3091	258	61	conceptualization	conceptualization	NOUN
admet-3091	258	62	,	,	PUNCT
admet-3091	258	63	supervision	supervision	NOUN
admet-3091	258	64	,	,	PUNCT
admet-3091	258	65	writing	writing	NOUN
admet-3091	258	66	,	,	PUNCT
admet-3091	258	67	review	review	NOUN
admet-3091	258	68	and	and	CCONJ
admet-3091	258	69	editing	editing	NOUN
admet-3091	258	70	,	,	PUNCT
admet-3091	258	71	project	project	NOUN
admet-3091	258	72	administration	administration	NOUN
admet-3091	258	73	.	.	PUNCT
admet-3091	259	1	data	datum	NOUN
admet-3091	259	2	availability	availability	NOUN
admet-3091	259	3	:	:	PUNCT
admet-3091	259	4	na	na	PART
admet-3091	259	5	ethics	ethic	NOUN
admet-3091	259	6	approval	approval	NOUN
admet-3091	259	7	and	and	CCONJ
admet-3091	259	8	consent	consent	NOUN
admet-3091	259	9	to	to	PART
admet-3091	259	10	participate	participate	VERB
admet-3091	259	11	:	:	PUNCT
admet-3091	259	12	na	na	PART
admet-3091	259	13	consent	consent	VERB
admet-3091	259	14	to	to	PART
admet-3091	259	15	participate	participate	VERB
admet-3091	259	16	:	:	PUNCT
admet-3091	259	17	na	na	PART
admet-3091	259	18	consent	consent	VERB
admet-3091	259	19	to	to	PART
admet-3091	259	20	publish	publish	VERB
admet-3091	259	21	:	:	PUNCT
admet-3091	259	22	na	na	ADP
admet-3091	259	23	references	reference	NOUN
admet-3091	259	24	[	[	X
admet-3091	259	25	1	1	NUM
admet-3091	259	26	]	]	X
admet-3091	259	27	d.j	d.j	PROPN
admet-3091	259	28	.	.	PROPN
admet-3091	259	29	hines	hines	PROPN
admet-3091	259	30	,	,	PUNCT
admet-3091	259	31	d.l	d.l	PROPN
admet-3091	259	32	.	.	PROPN
admet-3091	259	33	kaplan	kaplan	PROPN
admet-3091	259	34	.	.	PUNCT
admet-3091	260	1	poly	poly	ADJ
admet-3091	260	2	(	(	PUNCT
admet-3091	260	3	lactic	lactic	NOUN
admet-3091	260	4	-	-	PUNCT
admet-3091	260	5	co	co	NOUN
admet-3091	260	6	-	-	NOUN
admet-3091	260	7	glycolic	glycolic	NOUN
admet-3091	260	8	)	)	PUNCT
admet-3091	260	9	acid−	acid−	NOUN
admet-3091	260	10	controlled	control	VERB
admet-3091	260	11	-	-	PUNCT
admet-3091	260	12	release	release	NOUN
admet-3091	260	13	systems	system	NOUN
admet-3091	260	14	:	:	PUNCT
admet-3091	260	15	experimental	experimental	ADJ
admet-3091	260	16	and	and	CCONJ
admet-3091	260	17	modeling	modeling	NOUN
admet-3091	260	18	insights	insight	NOUN
admet-3091	260	19	.	.	PUNCT
admet-3091	261	1	critical	critical	ADJ
admet-3091	261	2	reviews	review	NOUN
admet-3091	261	3	™	™	VERB
admet-3091	261	4	in	in	ADP
admet-3091	261	5	therapeutic	therapeutic	ADJ
admet-3091	261	6	drug	drug	NOUN
admet-3091	261	7	carrier	carrier	NOUN
admet-3091	261	8	systems	system	NOUN
admet-3091	261	9	30	30	NUM
admet-3091	261	10	(	(	PUNCT
admet-3091	261	11	2013	2013	NUM
admet-3091	261	12	)	)	PUNCT
admet-3091	261	13	257	257	NUM
admet-3091	261	14	-	-	SYM
admet-3091	261	15	276	276	NUM
admet-3091	261	16	.	.	PUNCT
admet-3091	261	17	https://doi.org/10.1615/critrevtherdrugcarriersyst.2013006475	https://doi.org/10.1615/critrevtherdrugcarriersyst.2013006475	NOUN
admet-3091	261	18	[	[	X
admet-3091	261	19	2	2	NUM
admet-3091	261	20	]	]	X
admet-3091	261	21	h.k.makadia	h.k.makadia	NOUN
admet-3091	261	22	,	,	PUNCT
admet-3091	261	23	s.j.siegel	s.j.siegel	PROPN
admet-3091	261	24	.	.	PUNCT
admet-3091	262	1	poly	poly	ADJ
admet-3091	262	2	lactic	lactic	NOUN
admet-3091	262	3	-	-	PUNCT
admet-3091	262	4	co	co	NOUN
admet-3091	262	5	-	-	ADJ
admet-3091	262	6	glycolic	glycolic	ADJ
admet-3091	262	7	acid	acid	NOUN
admet-3091	262	8	(	(	PUNCT
admet-3091	262	9	plga	plga	NOUN
admet-3091	262	10	)	)	PUNCT
admet-3091	262	11	as	as	ADP
admet-3091	262	12	biodegradable	biodegradable	ADJ
admet-3091	262	13	controlled	control	VERB
admet-3091	262	14	drug	drug	NOUN
admet-3091	262	15	delivery	delivery	NOUN
admet-3091	262	16	carrier	carrier	NOUN
admet-3091	262	17	.	.	PUNCT
admet-3091	263	1	polymers	polymer	NOUN
admet-3091	263	2	3	3	NUM
admet-3091	263	3	(	(	PUNCT
admet-3091	263	4	2011)1377	2011)1377	NUM
admet-3091	263	5	-	-	SYM
admet-3091	263	6	1397	1397	NUM
admet-3091	263	7	.	.	PUNCT
admet-3091	264	1	https://doi.org/10.3390/polym3031377	https://doi.org/10.3390/polym3031377	NOUN
admet-3091	264	2	[	[	X
admet-3091	264	3	3	3	NUM
admet-3091	264	4	]	]	X
admet-3091	264	5	h.	h.	PROPN
admet-3091	264	6	bhardwaj	bhardwaj	PROPN
admet-3091	264	7	,	,	PUNCT
admet-3091	264	8	r.k	r.k	PROPN
admet-3091	264	9	.	.	PROPN
admet-3091	264	10	jangde	jangde	NOUN
admet-3091	264	11	.	.	PUNCT
admet-3091	265	1	current	current	ADJ
admet-3091	265	2	updated	update	VERB
admet-3091	265	3	review	review	NOUN
admet-3091	265	4	on	on	ADP
admet-3091	265	5	preparation	preparation	NOUN
admet-3091	265	6	of	of	ADP
admet-3091	265	7	polymeric	polymeric	ADJ
admet-3091	265	8	nanoparticles	nanoparticle	NOUN
admet-3091	265	9	for	for	ADP
admet-3091	265	10	drug	drug	NOUN
admet-3091	265	11	delivery	delivery	NOUN
admet-3091	265	12	and	and	CCONJ
admet-3091	265	13	biomedical	biomedical	ADJ
admet-3091	265	14	applications	application	NOUN
admet-3091	265	15	.	.	PUNCT
admet-3091	266	1	next	next	ADJ
admet-3091	266	2	nanotechnology	nanotechnology	NOUN
admet-3091	266	3	2	2	NUM
admet-3091	266	4	(	(	PUNCT
admet-3091	266	5	2023	2023	NUM
admet-3091	266	6	)	)	PUNCT
admet-3091	266	7	100013	100013	NUM
admet-3091	266	8	.	.	PUNCT
admet-3091	267	1	https://doi.org/10.1016/j.nxnano.2023.100013	https://doi.org/10.1016/j.nxnano.2023.100013	NOUN
admet-3091	267	2	[	[	X
admet-3091	267	3	4	4	X
admet-3091	267	4	]	]	X
admet-3091	267	5	m.b	m.b	PROPN
admet-3091	267	6	.	.	PROPN
admet-3091	267	7	giles	giles	PROPN
admet-3091	267	8	,	,	PUNCT
admet-3091	267	9	j.k	j.k	PROPN
admet-3091	267	10	.	.	PROPN
admet-3091	267	11	hong	hong	PROPN
admet-3091	267	12	,	,	PUNCT
admet-3091	267	13	y.	y.	PROPN
admet-3091	267	14	liu	liu	PROPN
admet-3091	267	15	,	,	PUNCT
admet-3091	267	16	j.	j.	PROPN
admet-3091	267	17	tang	tang	PROPN
admet-3091	267	18	,	,	PUNCT
admet-3091	267	19	t.	t.	PROPN
admet-3091	267	20	li	li	PROPN
admet-3091	267	21	,	,	PUNCT
admet-3091	267	22	a.	a.	PROPN
admet-3091	267	23	beig	beig	PROPN
admet-3091	267	24	,	,	PUNCT
admet-3091	267	25	a.	a.	NOUN
admet-3091	267	26	schwendeman	schwendeman	NOUN
admet-3091	267	27	,	,	PUNCT
admet-3091	267	28	s.p	s.p	PROPN
admet-3091	267	29	.	.	PROPN
admet-3091	267	30	schwendeman	schwendeman	NOUN
admet-3091	267	31	.	.	PUNCT
admet-3091	268	1	efficient	efficient	ADJ
admet-3091	268	2	aqueous	aqueous	ADJ
admet-3091	268	3	remote	remote	ADJ
admet-3091	268	4	loading	loading	NOUN
admet-3091	268	5	of	of	ADP
admet-3091	268	6	peptides	peptide	NOUN
admet-3091	268	7	in	in	ADP
admet-3091	268	8	poly	poly	ADJ
admet-3091	268	9	(	(	PUNCT
admet-3091	268	10	lactic	lactic	NOUN
admet-3091	268	11	-	-	PUNCT
admet-3091	268	12	co	co	NOUN
admet-3091	268	13	-	-	ADJ
admet-3091	268	14	glycolic	glycolic	ADJ
admet-3091	268	15	acid	acid	NOUN
admet-3091	268	16	)	)	PUNCT
admet-3091	268	17	.	.	PUNCT
admet-3091	269	1	nature	nature	NOUN
admet-3091	269	2	communications	communication	NOUN
admet-3091	269	3	13	13	NUM
admet-3091	269	4	(	(	PUNCT
admet-3091	269	5	2022	2022	NUM
admet-3091	269	6	)	)	PUNCT
admet-3091	269	7	3282	3282	NUM
admet-3091	269	8	.	.	PUNCT
admet-3091	270	1	https://doi.org/10.1038/s41467-022-30813-7	https://doi.org/10.1038/s41467-022-30813-7	NUM
admet-3091	271	1	[	[	X
admet-3091	271	2	5	5	NUM
admet-3091	271	3	]	]	X
admet-3091	271	4	y.	y.	PROPN
admet-3091	271	5	su	su	PROPN
admet-3091	271	6	,	,	PUNCT
admet-3091	271	7	b.	b.	PROPN
admet-3091	271	8	zhang	zhang	PROPN
admet-3091	271	9	,	,	PUNCT
admet-3091	271	10	r.	r.	PROPN
admet-3091	271	11	sun	sun	PROPN
admet-3091	271	12	,	,	PUNCT
admet-3091	271	13	w.	w.	PROPN
admet-3091	271	14	liu	liu	PROPN
admet-3091	271	15	,	,	PUNCT
admet-3091	271	16	q.	q.	PROPN
admet-3091	271	17	zhu	zhu	PROPN
admet-3091	271	18	,	,	PUNCT
admet-3091	271	19	x.	x.	PROPN
admet-3091	271	20	zhang	zhang	PROPN
admet-3091	271	21	,	,	PUNCT
admet-3091	271	22	r.	r.	PROPN
admet-3091	271	23	wang	wang	PROPN
admet-3091	271	24	,	,	PUNCT
admet-3091	271	25	c.	c.	PROPN
admet-3091	271	26	chen	chen	PROPN
admet-3091	271	27	.	.	PUNCT
admet-3091	272	1	plga	plga	NOUN
admet-3091	272	2	-	-	PUNCT
admet-3091	272	3	based	base	VERB
admet-3091	272	4	biodegradable	biodegradable	ADJ
admet-3091	272	5	microspheres	microsphere	NOUN
admet-3091	272	6	in	in	ADP
admet-3091	272	7	drug	drug	NOUN
admet-3091	272	8	delivery	delivery	NOUN
admet-3091	272	9	:	:	PUNCT
admet-3091	272	10	recent	recent	ADJ
admet-3091	272	11	advances	advance	NOUN
admet-3091	272	12	in	in	ADP
admet-3091	272	13	research	research	NOUN
admet-3091	272	14	application	application	NOUN
admet-3091	272	15	.	.	PUNCT
admet-3091	273	1	drug	drug	NOUN
admet-3091	273	2	delivery	delivery	NOUN
admet-3091	273	3	28	28	NUM
admet-3091	273	4	(	(	PUNCT
admet-3091	273	5	2021)13971418	2021)13971418	NUM
admet-3091	273	6	.	.	PUNCT
admet-3091	273	7	https://doi.org/10.1080/10717544.2021.1938756	https://doi.org/10.1080/10717544.2021.1938756	PUNCT
admet-3091	274	1	[	[	X
admet-3091	274	2	6	6	NUM
admet-3091	274	3	]	]	PUNCT
admet-3091	274	4	m.	m.	NOUN
admet-3091	274	5	pourmadadi	pourmadadi	PROPN
admet-3091	274	6	,	,	PUNCT
admet-3091	274	7	m.m	m.m	PROPN
admet-3091	274	8	.	.	PROPN
admet-3091	274	9	eshaghi	eshaghi	PROPN
admet-3091	274	10	,	,	PUNCT
admet-3091	274	11	s.	s.	PROPN
admet-3091	274	12	ostovar	ostovar	PROPN
admet-3091	274	13	,	,	PUNCT
admet-3091	274	14	z.	z.	PROPN
admet-3091	274	15	mohammadi	mohammadi	PROPN
admet-3091	274	16	,	,	PUNCT
admet-3091	274	17	r.k	r.k	PROPN
admet-3091	274	18	.	.	PROPN
admet-3091	274	19	sharma	sharma	PROPN
admet-3091	274	20	,	,	PUNCT
admet-3091	274	21	a.c	a.c	PROPN
admet-3091	274	22	.	.	PROPN
admet-3091	274	23	paiva	paiva	NOUN
admet-3091	274	24	-	-	PUNCT
admet-3091	274	25	santos	santos	PROPN
admet-3091	274	26	,	,	PUNCT
admet-3091	274	27	e.	e.	PROPN
admet-3091	274	28	rahmani	rahmani	PROPN
admet-3091	274	29	,	,	PUNCT
admet-3091	274	30	a.	a.	PROPN
admet-3091	274	31	rahdar	rahdar	PROPN
admet-3091	274	32	,	,	PUNCT
admet-3091	274	33	s.	s.	PROPN
admet-3091	274	34	pandey	pandey	PROPN
admet-3091	274	35	.	.	PUNCT
admet-3091	274	36	innovative	innovative	ADJ
admet-3091	274	37	nanomaterials	nanomaterial	NOUN
admet-3091	274	38	for	for	ADP
admet-3091	274	39	cancer	cancer	NOUN
admet-3091	274	40	diagnosis	diagnosis	NOUN
admet-3091	274	41	,	,	PUNCT
admet-3091	274	42	imaging	imaging	NOUN
admet-3091	274	43	,	,	PUNCT
admet-3091	274	44	and	and	CCONJ
admet-3091	274	45	therapy	therapy	NOUN
admet-3091	274	46	:	:	PUNCT
admet-3091	274	47	drug	drug	NOUN
admet-3091	274	48	delivery	delivery	NOUN
admet-3091	274	49	applications	application	NOUN
admet-3091	274	50	.	.	PUNCT
admet-3091	275	1	journal	journal	NOUN
admet-3091	275	2	of	of	ADP
admet-3091	275	3	drug	drug	NOUN
admet-3091	275	4	delivery	delivery	NOUN
admet-3091	275	5	science	science	NOUN
admet-3091	275	6	and	and	CCONJ
admet-3091	275	7	technology	technology	NOUN
admet-3091	275	8	82	82	NUM
admet-3091	275	9	(	(	PUNCT
admet-3091	275	10	2023)104357	2023)104357	NUM
admet-3091	275	11	.	.	PUNCT
admet-3091	276	1	https://doi.org/10.1016/j.jddst.2023.104357	https://doi.org/10.1016/j.jddst.2023.104357	PROPN
admet-3091	276	2	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	X
admet-3091	276	3	https://doi.org/10.1615/critrevtherdrugcarriersyst.2013006475	https://doi.org/10.1615/critrevtherdrugcarriersyst.2013006475	X
admet-3091	276	4	https://doi.org/10.3390/polym3031377	https://doi.org/10.3390/polym3031377	NOUN
admet-3091	276	5	https://doi.org/10.1016/j.nxnano.2023.100013	https://doi.org/10.1016/j.nxnano.2023.100013	NOUN
admet-3091	276	6	https://doi.org/10.1038/s41467-022-30813-7	https://doi.org/10.1038/s41467-022-30813-7	NUM
admet-3091	276	7	https://doi.org/10.1080/10717544.2021.1938756	https://doi.org/10.1080/10717544.2021.1938756	PUNCT
admet-3091	277	1	https://doi.org/10.1016/j.jddst.2023.104357	https://doi.org/10.1016/j.jddst.2023.104357	PROPN
admet-3091	277	2	m.	m.	PROPN
admet-3091	277	3	eshaghi	eshaghi	PROPN
admet-3091	277	4	et	et	PROPN
admet-3091	277	5	al	al	PROPN
admet-3091	277	6	.	.	PROPN
admet-3091	277	7	admet	admet	PROPN
admet-3091	277	8	&	&	CCONJ
admet-3091	277	9	dmpk	dmpk	PROPN
admet-3091	277	10	00(0	00(0	PROPN
admet-3091	277	11	)	)	PUNCT
admet-3091	277	12	(	(	PUNCT
admet-3091	277	13	2025	2025	NUM
admet-3091	277	14	)	)	PUNCT
admet-3091	277	15	3091	3091	NUM
admet-3091	277	16	14	14	NUM
admet-3091	278	1	[	[	X
admet-3091	278	2	7	7	NUM
admet-3091	278	3	]	]	X
admet-3091	278	4	p.w	p.w	PROPN
admet-3091	278	5	.	.	PROPN
admet-3091	278	6	lee	lee	PROPN
admet-3091	278	7	,	,	PUNCT
admet-3091	278	8	j.k	j.k	PROPN
admet-3091	278	9	.	.	PROPN
admet-3091	278	10	pokorski	pokorski	PROPN
admet-3091	278	11	.	.	PUNCT
admet-3091	279	1	poly	poly	ADJ
admet-3091	279	2	(	(	PUNCT
admet-3091	279	3	lactic‐co‐glycolic	lactic‐co‐glycolic	ADJ
admet-3091	279	4	acid	acid	ADJ
admet-3091	279	5	)	)	PUNCT
admet-3091	279	6	devices	device	NOUN
admet-3091	279	7	:	:	PUNCT
admet-3091	279	8	production	production	NOUN
admet-3091	279	9	and	and	CCONJ
admet-3091	279	10	applications	application	NOUN
admet-3091	279	11	for	for	ADP
admet-3091	279	12	sustained	sustained	ADJ
admet-3091	279	13	protein	protein	NOUN
admet-3091	279	14	delivery	delivery	NOUN
admet-3091	279	15	.	.	PUNCT
admet-3091	280	1	wiley	wiley	PROPN
admet-3091	280	2	interdisciplinary	interdisciplinary	ADJ
admet-3091	280	3	reviews	review	NOUN
admet-3091	280	4	:	:	PUNCT
admet-3091	280	5	nanomedicine	nanomedicine	NOUN
admet-3091	280	6	and	and	CCONJ
admet-3091	280	7	nanobiotechnology	nanobiotechnology	NOUN
admet-3091	280	8	10	10	NUM
admet-3091	280	9	(	(	PUNCT
admet-3091	280	10	2018)1516	2018)1516	NUM
admet-3091	280	11	.	.	PUNCT
admet-3091	281	1	https://doi.org/10.1002/wnan.1516	https://doi.org/10.1002/wnan.1516	NOUN
admet-3091	282	1	[	[	X
admet-3091	282	2	8	8	NUM
admet-3091	282	3	]	]	PUNCT
admet-3091	282	4	x.	x.	NOUN
admet-3091	282	5	luan	luan	PROPN
admet-3091	282	6	,	,	PUNCT
admet-3091	282	7	r.	r.	PROPN
admet-3091	282	8	bodmeier	bodmeier	PROPN
admet-3091	282	9	.	.	PUNCT
admet-3091	283	1	influence	influence	NOUN
admet-3091	283	2	of	of	ADP
admet-3091	283	3	the	the	DET
admet-3091	283	4	poly	poly	ADJ
admet-3091	283	5	(	(	PUNCT
admet-3091	283	6	lactide	lactide	NOUN
admet-3091	283	7	-	-	PUNCT
admet-3091	283	8	co	co	NOUN
admet-3091	283	9	-	-	ADJ
admet-3091	283	10	glycolide	glycolide	ADJ
admet-3091	283	11	)	)	PUNCT
admet-3091	283	12	type	type	NOUN
admet-3091	283	13	on	on	ADP
admet-3091	283	14	the	the	DET
admet-3091	283	15	leuprolide	leuprolide	NOUN
admet-3091	283	16	release	release	NOUN
admet-3091	283	17	from	from	ADP
admet-3091	283	18	in	in	ADP
admet-3091	283	19	situ	situ	ADJ
admet-3091	283	20	forming	form	VERB
admet-3091	283	21	microparticle	microparticle	NOUN
admet-3091	283	22	systems	system	NOUN
admet-3091	283	23	.	.	PUNCT
admet-3091	284	1	journal	journal	PROPN
admet-3091	284	2	of	of	ADP
admet-3091	284	3	controlled	control	VERB
admet-3091	284	4	release	release	NOUN
admet-3091	284	5	110	110	NUM
admet-3091	284	6	(	(	PUNCT
admet-3091	284	7	2006	2006	NUM
admet-3091	284	8	)	)	PUNCT
admet-3091	284	9	266	266	NUM
admet-3091	284	10	-	-	SYM
admet-3091	284	11	272	272	NUM
admet-3091	284	12	.	.	PUNCT
admet-3091	285	1	https://doi.org/10.1016/j.jconrel.2005.10.005	https://doi.org/10.1016/j.jconrel.2005.10.005	NOUN
admet-3091	285	2	[	[	X
admet-3091	285	3	9	9	NUM
admet-3091	285	4	]	]	PUNCT
admet-3091	285	5	j.	j.	PROPN
admet-3091	285	6	yang	yang	PROPN
admet-3091	285	7	,	,	PUNCT
admet-3091	285	8	h.	h.	PROPN
admet-3091	285	9	zeng	zeng	PROPN
admet-3091	285	10	,	,	PUNCT
admet-3091	285	11	y.	y.	PROPN
admet-3091	285	12	luo	luo	PROPN
admet-3091	285	13	,	,	PUNCT
admet-3091	285	14	y.	y.	PROPN
admet-3091	285	15	chen	chen	PROPN
admet-3091	285	16	,	,	PUNCT
admet-3091	285	17	m.	m.	PROPN
admet-3091	285	18	wang	wang	PROPN
admet-3091	285	19	,	,	PUNCT
admet-3091	285	20	c.	c.	PROPN
admet-3091	285	21	wu	wu	PROPN
admet-3091	285	22	,	,	PUNCT
admet-3091	285	23	p.	p.	PROPN
admet-3091	285	24	hu	hu	PROPN
admet-3091	285	25	.	.	PUNCT
admet-3091	286	1	recent	recent	ADJ
admet-3091	286	2	applications	application	NOUN
admet-3091	286	3	of	of	ADP
admet-3091	286	4	plga	plga	NOUN
admet-3091	286	5	in	in	ADP
admet-3091	286	6	drug	drug	NOUN
admet-3091	286	7	delivery	delivery	NOUN
admet-3091	286	8	systems	system	NOUN
admet-3091	286	9	.	.	PUNCT
admet-3091	287	1	polymers	polymer	NOUN
admet-3091	287	2	16	16	NUM
admet-3091	287	3	(	(	PUNCT
admet-3091	287	4	2024)2606	2024)2606	NUM
admet-3091	287	5	.	.	PUNCT
admet-3091	288	1	https://doi.org/10.3390/polym16182606	https://doi.org/10.3390/polym16182606	PROPN
admet-3091	288	2	[	[	X
admet-3091	288	3	10	10	NUM
admet-3091	288	4	]	]	PUNCT
admet-3091	288	5	m.	m.	PROPN
admet-3091	288	6	ochi	ochi	PROPN
admet-3091	288	7	,	,	PUNCT
admet-3091	288	8	b.	b.	PROPN
admet-3091	288	9	wan	wan	PROPN
admet-3091	288	10	,	,	PUNCT
admet-3091	288	11	q.	q.	PROPN
admet-3091	288	12	bao	bao	PROPN
admet-3091	288	13	,	,	PUNCT
admet-3091	288	14	d.j	d.j	PROPN
admet-3091	288	15	.	.	PROPN
admet-3091	288	16	burgess	burgess	PROPN
admet-3091	288	17	.	.	PUNCT
admet-3091	289	1	influence	influence	NOUN
admet-3091	289	2	of	of	ADP
admet-3091	289	3	plga	plga	VERB
admet-3091	289	4	molecular	molecular	ADJ
admet-3091	289	5	weight	weight	NOUN
admet-3091	289	6	distribution	distribution	NOUN
admet-3091	289	7	on	on	ADP
admet-3091	289	8	leuprolide	leuprolide	NOUN
admet-3091	289	9	release	release	NOUN
admet-3091	289	10	from	from	ADP
admet-3091	289	11	microspheres	microsphere	NOUN
admet-3091	289	12	.	.	PUNCT
admet-3091	290	1	international	international	ADJ
admet-3091	290	2	journal	journal	PROPN
admet-3091	290	3	of	of	ADP
admet-3091	290	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	290	5	599	599	NUM
admet-3091	290	6	(	(	PUNCT
admet-3091	290	7	2021)120450	2021)120450	ADV
admet-3091	290	8	.	.	PUNCT
admet-3091	291	1	https://doi.org/10.1016/j.ijpharm.2021.120450	https://doi.org/10.1016/j.ijpharm.2021.120450	PROPN
admet-3091	291	2	[	[	X
admet-3091	291	3	11	11	NUM
admet-3091	291	4	]	]	PUNCT
admet-3091	291	5	h.	h.	PROPN
admet-3091	291	6	kranz	kranz	PROPN
admet-3091	291	7	,	,	PUNCT
admet-3091	291	8	r.	r.	PROPN
admet-3091	291	9	bodmeier	bodmeier	PROPN
admet-3091	291	10	.	.	PUNCT
admet-3091	292	1	a	a	DET
admet-3091	292	2	novel	novel	NOUN
admet-3091	292	3	in	in	ADP
admet-3091	292	4	situ	situ	ADJ
admet-3091	292	5	forming	form	VERB
admet-3091	292	6	drug	drug	NOUN
admet-3091	292	7	delivery	delivery	NOUN
admet-3091	292	8	system	system	NOUN
admet-3091	292	9	for	for	ADP
admet-3091	292	10	controlled	control	VERB
admet-3091	292	11	parenteral	parenteral	ADJ
admet-3091	292	12	drug	drug	NOUN
admet-3091	292	13	delivery	delivery	NOUN
admet-3091	292	14	.	.	PUNCT
admet-3091	293	1	international	international	ADJ
admet-3091	293	2	journal	journal	PROPN
admet-3091	293	3	of	of	ADP
admet-3091	293	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	293	5	332	332	NUM
admet-3091	293	6	(	(	PUNCT
admet-3091	293	7	2007	2007	NUM
admet-3091	293	8	)	)	PUNCT
admet-3091	293	9	107	107	NUM
admet-3091	293	10	-	-	SYM
admet-3091	293	11	114	114	NUM
admet-3091	293	12	.	.	PUNCT
admet-3091	294	1	https://doi.org/10.1016/j.ijpharm.2006.09.033	https://doi.org/10.1016/j.ijpharm.2006.09.033	NOUN
admet-3091	294	2	[	[	X
admet-3091	294	3	12	12	NUM
admet-3091	294	4	]	]	X
admet-3091	294	5	p.g	p.g	PROPN
admet-3091	294	6	.	.	PROPN
admet-3091	294	7	schmidt	schmidt	PROPN
admet-3091	294	8	,	,	PUNCT
admet-3091	294	9	k.m	k.m	PROPN
admet-3091	294	10	.	.	PROPN
admet-3091	294	11	campbell	campbell	PROPN
admet-3091	294	12	,	,	PUNCT
admet-3091	294	13	k.d	k.d	PROPN
admet-3091	294	14	.	.	PROPN
admet-3091	294	15	hinds	hinds	PROPN
admet-3091	294	16	,	,	PUNCT
admet-3091	294	17	g.p	g.p	PROPN
admet-3091	294	18	.	.	PROPN
admet-3091	294	19	cook	cook	PROPN
admet-3091	294	20	.	.	PUNCT
admet-3091	295	1	pegylated	pegylate	VERB
admet-3091	295	2	bioactive	bioactive	ADJ
admet-3091	295	3	molecules	molecule	NOUN
admet-3091	295	4	in	in	ADP
admet-3091	295	5	biodegradable	biodegradable	ADJ
admet-3091	295	6	polymer	polymer	NOUN
admet-3091	295	7	microparticles	microparticle	NOUN
admet-3091	295	8	.	.	PUNCT
admet-3091	296	1	expert	expert	ADJ
admet-3091	296	2	opinion	opinion	NOUN
admet-3091	296	3	on	on	ADP
admet-3091	296	4	biological	biological	ADJ
admet-3091	296	5	therapy	therapy	NOUN
admet-3091	296	6	7	7	NUM
admet-3091	296	7	(	(	PUNCT
admet-3091	296	8	2007	2007	NUM
admet-3091	296	9	)	)	PUNCT
admet-3091	296	10	1427	1427	NUM
admet-3091	296	11	-	-	SYM
admet-3091	296	12	1436	1436	NUM
admet-3091	296	13	.	.	PUNCT
admet-3091	297	1	https://doi.org/10.1517/14712598.7.9.1427	https://doi.org/10.1517/14712598.7.9.1427	PUNCT
admet-3091	298	1	[	[	X
admet-3091	298	2	13	13	NUM
admet-3091	298	3	]	]	SYM
admet-3091	298	4	s.c	s.c	PROPN
admet-3091	298	5	.	.	PROPN
admet-3091	298	6	balmert	balmert	PROPN
admet-3091	298	7	,	,	PUNCT
admet-3091	298	8	a.c	a.c	PROPN
admet-3091	298	9	.	.	PROPN
admet-3091	298	10	zmolek	zmolek	PROPN
admet-3091	298	11	,	,	PUNCT
admet-3091	298	12	a.j	a.j	PROPN
admet-3091	298	13	.	.	PROPN
admet-3091	298	14	glowacki	glowacki	PROPN
admet-3091	298	15	,	,	PUNCT
admet-3091	298	16	t.d	t.d	PROPN
admet-3091	298	17	.	.	PROPN
admet-3091	298	18	knab	knab	PROPN
admet-3091	298	19	,	,	PUNCT
admet-3091	298	20	s.n	s.n	PROPN
admet-3091	298	21	.	.	PROPN
admet-3091	298	22	rothstein	rothstein	PROPN
admet-3091	298	23	,	,	PUNCT
admet-3091	298	24	j.m	j.m	PROPN
admet-3091	298	25	.	.	PROPN
admet-3091	298	26	wokpetah	wokpetah	PROPN
admet-3091	298	27	,	,	PUNCT
admet-3091	298	28	m.v	m.v	PROPN
admet-3091	298	29	.	.	PROPN
admet-3091	298	30	fedorchak	fedorchak	PROPN
admet-3091	298	31	,	,	PUNCT
admet-3091	298	32	s.r	s.r	PROPN
admet-3091	299	1	.	.	PROPN
admet-3091	299	2	little	little	ADJ
admet-3091	299	3	.	.	PUNCT
admet-3091	300	1	positive	positive	ADJ
admet-3091	300	2	charge	charge	NOUN
admet-3091	300	3	of	of	ADP
admet-3091	300	4	“	"	PUNCT
admet-3091	300	5	sticky	sticky	ADJ
admet-3091	300	6	”	"	PUNCT
admet-3091	300	7	peptides	peptide	NOUN
admet-3091	300	8	and	and	CCONJ
admet-3091	300	9	proteins	protein	NOUN
admet-3091	300	10	impedes	impede	VERB
admet-3091	300	11	release	release	NOUN
admet-3091	300	12	from	from	ADP
admet-3091	300	13	negatively	negatively	ADV
admet-3091	300	14	charged	charge	VERB
admet-3091	300	15	plga	plga	NOUN
admet-3091	300	16	matrices	matrix	NOUN
admet-3091	300	17	.	.	PUNCT
admet-3091	301	1	journal	journal	NOUN
admet-3091	301	2	of	of	ADP
admet-3091	301	3	materials	material	NOUN
admet-3091	301	4	chemistry	chemistry	NOUN
admet-3091	301	5	b	b	NOUN
admet-3091	301	6	3	3	NUM
admet-3091	301	7	(	(	PUNCT
admet-3091	301	8	2015	2015	NUM
admet-3091	301	9	)	)	PUNCT
admet-3091	301	10	4723	4723	NUM
admet-3091	301	11	-	-	SYM
admet-3091	301	12	4734	4734	NUM
admet-3091	301	13	.	.	PUNCT
admet-3091	302	1	https://doi.org/10.1039/c5tb00515a	https://doi.org/10.1039/c5tb00515a	PROPN
admet-3091	303	1	[	[	X
admet-3091	303	2	14	14	NUM
admet-3091	303	3	]	]	X
admet-3091	303	4	m.h	m.h	PROPN
admet-3091	303	5	.	.	PROPN
admet-3091	303	6	zada	zada	PROPN
admet-3091	303	7	,	,	PUNCT
admet-3091	303	8	y.	y.	PROPN
admet-3091	303	9	rottenberg	rottenberg	PROPN
admet-3091	303	10	,	,	PUNCT
admet-3091	303	11	a.j	a.j	PROPN
admet-3091	303	12	.	.	PROPN
admet-3091	303	13	domb	domb	PROPN
admet-3091	303	14	.	.	PUNCT
admet-3091	304	1	peptide	peptide	NOUN
admet-3091	304	2	loaded	load	VERB
admet-3091	304	3	polymeric	polymeric	ADJ
admet-3091	304	4	nanoparticles	nanoparticle	NOUN
admet-3091	304	5	by	by	ADP
admet-3091	304	6	non	non	ADJ
admet-3091	304	7	-	-	ADJ
admet-3091	304	8	aqueous	aqueous	ADJ
admet-3091	304	9	nanoprecipitation	nanoprecipitation	NOUN
admet-3091	304	10	.	.	PUNCT
admet-3091	305	1	journal	journal	PROPN
admet-3091	305	2	of	of	ADP
admet-3091	305	3	colloid	colloid	NOUN
admet-3091	305	4	and	and	CCONJ
admet-3091	305	5	interface	interface	NOUN
admet-3091	305	6	science	science	NOUN
admet-3091	305	7	622	622	NUM
admet-3091	305	8	(	(	PUNCT
admet-3091	305	9	2022	2022	NUM
admet-3091	305	10	)	)	PUNCT
admet-3091	305	11	904	904	NUM
admet-3091	305	12	-	-	SYM
admet-3091	305	13	913	913	NUM
admet-3091	305	14	.	.	PUNCT
admet-3091	306	1	https://doi.org/10.1016/j.jcis.2022.05.007	https://doi.org/10.1016/j.jcis.2022.05.007	PROPN
admet-3091	307	1	[	[	X
admet-3091	307	2	15	15	NUM
admet-3091	307	3	]	]	X
admet-3091	307	4	h.b	h.b	PROPN
admet-3091	307	5	.	.	PROPN
admet-3091	307	6	ravivarapu	ravivarapu	PROPN
admet-3091	307	7	,	,	PUNCT
admet-3091	307	8	k.	k.	PROPN
admet-3091	307	9	burton	burton	PROPN
admet-3091	307	10	,	,	PUNCT
admet-3091	307	11	p.p	p.p	PROPN
admet-3091	307	12	.	.	PUNCT
admet-3091	307	13	deluca	deluca	PROPN
admet-3091	307	14	.	.	PUNCT
admet-3091	308	1	polymer	polymer	NOUN
admet-3091	308	2	and	and	CCONJ
admet-3091	308	3	microsphere	microsphere	AUX
admet-3091	308	4	blending	blend	VERB
admet-3091	308	5	to	to	PART
admet-3091	308	6	alter	alter	VERB
admet-3091	308	7	the	the	DET
admet-3091	308	8	release	release	NOUN
admet-3091	308	9	of	of	ADP
admet-3091	308	10	a	a	DET
admet-3091	308	11	peptide	peptide	NOUN
admet-3091	308	12	from	from	ADP
admet-3091	308	13	plga	plga	NOUN
admet-3091	308	14	microspheres	microsphere	NOUN
admet-3091	308	15	.	.	PUNCT
admet-3091	309	1	european	european	PROPN
admet-3091	309	2	journal	journal	PROPN
admet-3091	309	3	of	of	ADP
admet-3091	309	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	309	5	and	and	CCONJ
admet-3091	309	6	biopharmaceutics	biopharmaceutic	NOUN
admet-3091	309	7	50	50	NUM
admet-3091	309	8	(	(	PUNCT
admet-3091	309	9	2000	2000	NUM
admet-3091	309	10	)	)	PUNCT
admet-3091	309	11	263	263	NUM
admet-3091	309	12	-	-	SYM
admet-3091	309	13	270	270	NUM
admet-3091	309	14	.	.	PUNCT
admet-3091	310	1	https://doi.org/10.1016/s0939-6411(00)00099-0	https://doi.org/10.1016/s0939-6411(00)00099-0	X
admet-3091	311	1	[	[	X
admet-3091	311	2	16	16	NUM
admet-3091	311	3	]	]	PUNCT
admet-3091	311	4	j.	j.	PROPN
admet-3091	311	5	kim	kim	PROPN
admet-3091	311	6	,	,	PUNCT
admet-3091	311	7	r.l	r.l	PROPN
admet-3091	311	8	.	.	PROPN
admet-3091	311	9	e	e	PROPN
admet-3091	311	10	silva	silva	PROPN
admet-3091	311	11	,	,	PUNCT
admet-3091	311	12	r.b	r.b	PROPN
admet-3091	311	13	.	.	PROPN
admet-3091	311	14	shmueli	shmueli	PROPN
admet-3091	311	15	,	,	PUNCT
admet-3091	311	16	a.c	a.c	PROPN
admet-3091	311	17	.	.	PROPN
admet-3091	311	18	mirando	mirando	PROPN
admet-3091	311	19	,	,	PUNCT
admet-3091	311	20	s.y	s.y	PROPN
admet-3091	311	21	.	.	PROPN
admet-3091	311	22	tzeng	tzeng	PROPN
admet-3091	311	23	,	,	PUNCT
admet-3091	311	24	n.b	n.b	PROPN
admet-3091	311	25	.	.	PROPN
admet-3091	311	26	pandey	pandey	PROPN
admet-3091	311	27	,	,	PUNCT
admet-3091	311	28	e.	e.	PROPN
admet-3091	311	29	ben	ben	PROPN
admet-3091	311	30	-	-	PROPN
admet-3091	311	31	akiva	akiva	PROPN
admet-3091	311	32	,	,	PUNCT
admet-3091	311	33	a.s	a.s	PROPN
admet-3091	311	34	.	.	PROPN
admet-3091	311	35	popel	popel	PROPN
admet-3091	311	36	,	,	PUNCT
admet-3091	311	37	p.a	p.a	PROPN
admet-3091	311	38	.	.	PROPN
admet-3091	311	39	campochiaro	campochiaro	PROPN
admet-3091	311	40	,	,	PUNCT
admet-3091	311	41	j.j	j.j	PROPN
admet-3091	311	42	.	.	PROPN
admet-3091	311	43	green	green	PROPN
admet-3091	311	44	.	.	PUNCT
admet-3091	312	1	anisotropic	anisotropic	NOUN
admet-3091	312	2	poly	poly	ADJ
admet-3091	312	3	(	(	PUNCT
admet-3091	312	4	lactic	lactic	NOUN
admet-3091	312	5	-	-	PUNCT
admet-3091	312	6	co	co	NOUN
admet-3091	312	7	-	-	ADJ
admet-3091	312	8	glycolic	glycolic	ADJ
admet-3091	312	9	acid	acid	NOUN
admet-3091	312	10	)	)	PUNCT
admet-3091	312	11	microparticles	microparticle	NOUN
admet-3091	312	12	enable	enable	VERB
admet-3091	312	13	sustained	sustained	ADJ
admet-3091	312	14	release	release	NOUN
admet-3091	312	15	of	of	ADP
admet-3091	312	16	a	a	DET
admet-3091	312	17	peptide	peptide	NOUN
admet-3091	312	18	for	for	ADP
admet-3091	312	19	long	long	ADJ
admet-3091	312	20	-	-	PUNCT
admet-3091	312	21	term	term	NOUN
admet-3091	312	22	inhibition	inhibition	NOUN
admet-3091	312	23	of	of	ADP
admet-3091	312	24	ocular	ocular	ADJ
admet-3091	312	25	neovascularization	neovascularization	NOUN
admet-3091	312	26	.	.	PUNCT
admet-3091	313	1	acta	acta	PROPN
admet-3091	313	2	biomaterialia	biomaterialia	PROPN
admet-3091	313	3	97	97	NUM
admet-3091	313	4	(	(	PUNCT
admet-3091	313	5	2019	2019	NUM
admet-3091	313	6	)	)	PUNCT
admet-3091	313	7	451	451	NUM
admet-3091	313	8	-	-	SYM
admet-3091	313	9	460	460	NUM
admet-3091	313	10	.	.	PUNCT
admet-3091	314	1	https://doi.org/10.1016/j.actbio.2019.07.054	https://doi.org/10.1016/j.actbio.2019.07.054	PROPN
admet-3091	315	1	[	[	X
admet-3091	315	2	17	17	NUM
admet-3091	315	3	]	]	PUNCT
admet-3091	315	4	a.	a.	NOUN
admet-3091	315	5	vlachopoulos	vlachopoulos	PROPN
admet-3091	315	6	,	,	PUNCT
admet-3091	315	7	g.	g.	PROPN
admet-3091	315	8	karlioti	karlioti	PROPN
admet-3091	315	9	,	,	PUNCT
admet-3091	315	10	e.	e.	PROPN
admet-3091	315	11	balla	balla	PROPN
admet-3091	315	12	,	,	PUNCT
admet-3091	315	13	v.	v.	PROPN
admet-3091	315	14	daniilidis	daniilidis	PROPN
admet-3091	315	15	,	,	PUNCT
admet-3091	315	16	t.	t.	PROPN
admet-3091	315	17	kalamas	kalamas	PROPN
admet-3091	315	18	,	,	PUNCT
admet-3091	315	19	m.	m.	NOUN
admet-3091	315	20	stefanidou	stefanidou	PROPN
admet-3091	315	21	,	,	PUNCT
admet-3091	315	22	n.d	n.d	PROPN
admet-3091	315	23	.	.	PROPN
admet-3091	315	24	bikiaris	bikiaris	PROPN
admet-3091	315	25	,	,	PUNCT
admet-3091	315	26	e.	e.	PROPN
admet-3091	315	27	christodoulou	christodoulou	PROPN
admet-3091	315	28	,	,	PUNCT
admet-3091	315	29	i.	i.	PROPN
admet-3091	315	30	koumentakou	koumentakou	PROPN
admet-3091	315	31	,	,	PUNCT
admet-3091	315	32	e.	e.	PROPN
admet-3091	315	33	karavas	karavas	PROPN
admet-3091	315	34	,	,	PUNCT
admet-3091	315	35	d.n	d.n	PROPN
admet-3091	315	36	.	.	PROPN
admet-3091	315	37	bikiaris	bikiaris	PROPN
admet-3091	315	38	.	.	PUNCT
admet-3091	316	1	poly	poly	ADJ
admet-3091	316	2	(	(	PUNCT
admet-3091	316	3	lactic	lactic	ADJ
admet-3091	316	4	acid)-based	acid)-base	VERB
admet-3091	316	5	microparticles	microparticle	NOUN
admet-3091	316	6	for	for	ADP
admet-3091	316	7	drug	drug	NOUN
admet-3091	316	8	delivery	delivery	NOUN
admet-3091	316	9	applications	application	NOUN
admet-3091	316	10	:	:	PUNCT
admet-3091	316	11	an	an	DET
admet-3091	316	12	overview	overview	NOUN
admet-3091	316	13	of	of	ADP
admet-3091	316	14	recent	recent	ADJ
admet-3091	316	15	advances	advance	NOUN
admet-3091	316	16	.	.	PUNCT
admet-3091	317	1	pharmaceutics	pharmaceutic	NOUN
admet-3091	317	2	14	14	NUM
admet-3091	317	3	(	(	PUNCT
admet-3091	317	4	2022	2022	NUM
admet-3091	317	5	)	)	PUNCT
admet-3091	317	6	359	359	NUM
admet-3091	317	7	.	.	PUNCT
admet-3091	318	1	https://doi.org/10.3390/pharmaceutics14020359	https://doi.org/10.3390/pharmaceutics14020359	X
admet-3091	319	1	[	[	X
admet-3091	319	2	18	18	NUM
admet-3091	319	3	]	]	PUNCT
admet-3091	319	4	m.	m.	NOUN
admet-3091	319	5	allahyari	allahyari	PROPN
admet-3091	319	6	,	,	PUNCT
admet-3091	319	7	e.	e.	PROPN
admet-3091	319	8	mohit	mohit	PROPN
admet-3091	319	9	.	.	PUNCT
admet-3091	320	1	peptide	peptide	NOUN
admet-3091	320	2	/	/	SYM
admet-3091	320	3	protein	protein	NOUN
admet-3091	320	4	vaccine	vaccine	NOUN
admet-3091	320	5	delivery	delivery	NOUN
admet-3091	320	6	system	system	NOUN
admet-3091	320	7	based	base	VERB
admet-3091	320	8	on	on	ADP
admet-3091	320	9	plga	plga	NOUN
admet-3091	320	10	particles	particle	NOUN
admet-3091	320	11	.	.	PUNCT
admet-3091	321	1	human	human	ADJ
admet-3091	321	2	vaccines	vaccine	NOUN
admet-3091	321	3	&	&	CCONJ
admet-3091	321	4	immunotherapeutics	immunotherapeutics	PROPN
admet-3091	321	5	12(2016)806	12(2016)806	PROPN
admet-3091	321	6	-	-	PUNCT
admet-3091	321	7	828	828	NUM
admet-3091	321	8	.	.	PUNCT
admet-3091	321	9	https://doi.org/10.1080/21645515.2015.1102804	https://doi.org/10.1080/21645515.2015.1102804	X
admet-3091	322	1	[	[	X
admet-3091	322	2	19	19	NUM
admet-3091	322	3	]	]	PUNCT
admet-3091	322	4	j.	j.	PROPN
admet-3091	322	5	yoo	yoo	PROPN
admet-3091	322	6	,	,	PUNCT
admet-3091	322	7	y.y	y.y	PROPN
admet-3091	322	8	.	.	PROPN
admet-3091	322	9	won	won	PROPN
admet-3091	322	10	.	.	PUNCT
admet-3091	323	1	phenomenology	phenomenology	NOUN
admet-3091	323	2	of	of	ADP
admet-3091	323	3	the	the	DET
admet-3091	323	4	initial	initial	ADJ
admet-3091	323	5	burst	burst	ADJ
admet-3091	323	6	release	release	NOUN
admet-3091	323	7	of	of	ADP
admet-3091	323	8	drugs	drug	NOUN
admet-3091	323	9	from	from	ADP
admet-3091	323	10	plga	plga	NOUN
admet-3091	323	11	microparticles	microparticle	NOUN
admet-3091	323	12	.	.	PUNCT
admet-3091	324	1	acs	acs	PROPN
admet-3091	324	2	biomaterials	biomaterials	PROPN
admet-3091	324	3	science	science	PROPN
admet-3091	324	4	&	&	CCONJ
admet-3091	324	5	engineering	engineering	PROPN
admet-3091	324	6	6	6	NUM
admet-3091	324	7	(	(	PUNCT
admet-3091	324	8	2020	2020	NUM
admet-3091	324	9	)	)	PUNCT
admet-3091	324	10	6053	6053	NUM
admet-3091	324	11	-	-	SYM
admet-3091	324	12	6062	6062	NUM
admet-3091	324	13	.	.	PUNCT
admet-3091	325	1	https://doi.org/10.1021/acsbiomaterials.0c01228	https://doi.org/10.1021/acsbiomaterials.0c01228	PROPN
admet-3091	326	1	[	[	X
admet-3091	326	2	20	20	NUM
admet-3091	326	3	]	]	X
admet-3091	326	4	k.t	k.t	PROPN
admet-3091	326	5	.	.	PROPN
admet-3091	326	6	santhosh	santhosh	PROPN
admet-3091	326	7	,	,	PUNCT
admet-3091	326	8	a.	a.	NOUN
admet-3091	326	9	alizadeh	alizadeh	PROPN
admet-3091	326	10	,	,	PUNCT
admet-3091	326	11	s.	s.	PROPN
admet-3091	326	12	karimi	karimi	PROPN
admet-3091	326	13	-	-	PUNCT
admet-3091	326	14	abdolrezaee	abdolrezaee	PROPN
admet-3091	326	15	.	.	PUNCT
admet-3091	327	1	design	design	NOUN
admet-3091	327	2	and	and	CCONJ
admet-3091	327	3	optimization	optimization	NOUN
admet-3091	327	4	of	of	ADP
admet-3091	327	5	plga	plga	NOUN
admet-3091	327	6	microparticles	microparticle	NOUN
admet-3091	327	7	for	for	ADP
admet-3091	327	8	controlled	control	VERB
admet-3091	327	9	and	and	CCONJ
admet-3091	327	10	local	local	ADJ
admet-3091	327	11	delivery	delivery	NOUN
admet-3091	327	12	of	of	ADP
admet-3091	327	13	neuregulin-1	neuregulin-1	NUM
admet-3091	327	14	in	in	ADP
admet-3091	327	15	traumatic	traumatic	ADJ
admet-3091	327	16	spinal	spinal	NOUN
admet-3091	327	17	cord	cord	NOUN
admet-3091	327	18	injury	injury	NOUN
admet-3091	327	19	.	.	PUNCT
admet-3091	328	1	journal	journal	PROPN
admet-3091	328	2	of	of	ADP
admet-3091	328	3	controlled	control	VERB
admet-3091	328	4	release	release	NOUN
admet-3091	328	5	261	261	NUM
admet-3091	328	6	(	(	PUNCT
admet-3091	328	7	2017	2017	NUM
admet-3091	328	8	)	)	PUNCT
admet-3091	328	9	147	147	NUM
admet-3091	328	10	-	-	SYM
admet-3091	328	11	162	162	NUM
admet-3091	328	12	.	.	PUNCT
admet-3091	329	1	https://doi.org/10.1016/j.jconrel.2017.06.030	https://doi.org/10.1016/j.jconrel.2017.06.030	PROPN
admet-3091	329	2	[	[	X
admet-3091	329	3	21	21	NUM
admet-3091	329	4	]	]	X
admet-3091	329	5	c.	c.	PROPN
admet-3091	329	6	de	de	X
admet-3091	329	7	soricellis	soricellis	PROPN
admet-3091	329	8	,	,	PUNCT
admet-3091	329	9	c.	c.	PROPN
admet-3091	329	10	laigle	laigle	PROPN
admet-3091	329	11	,	,	PUNCT
admet-3091	329	12	l.	l.	PROPN
admet-3091	329	13	spinelli	spinelli	PROPN
admet-3091	329	14	,	,	PUNCT
admet-3091	329	15	m.c	m.c	PROPN
admet-3091	329	16	.	.	PROPN
admet-3091	329	17	monti	monti	PROPN
admet-3091	329	18	,	,	PUNCT
admet-3091	329	19	c.	c.	PROPN
admet-3091	329	20	amante	amante	PROPN
admet-3091	329	21	,	,	PUNCT
admet-3091	329	22	p.	p.	PROPN
admet-3091	329	23	russo	russo	PROPN
admet-3091	329	24	,	,	PUNCT
admet-3091	329	25	r.p	r.p	PROPN
admet-3091	329	26	.	.	PROPN
admet-3091	329	27	aquino	aquino	PROPN
admet-3091	329	28	,	,	PUNCT
admet-3091	329	29	p.	p.	NOUN
admet-3091	329	30	rousselle	rousselle	NOUN
admet-3091	329	31	,	,	PUNCT
admet-3091	329	32	g.	g.	PROPN
admet-3091	329	33	lollo	lollo	PROPN
admet-3091	329	34	,	,	PUNCT
admet-3091	329	35	p.	p.	NOUN
admet-3091	329	36	del	del	NOUN
admet-3091	329	37	gaudio	gaudio	PROPN
admet-3091	329	38	.	.	PUNCT
admet-3091	330	1	lipidized	lipidize	VERB
admet-3091	330	2	ll37	ll37	PROPN
admet-3091	330	3	-	-	PUNCT
admet-3091	330	4	loaded	load	VERB
admet-3091	330	5	plga	plga	NOUN
admet-3091	330	6	nanocarriers	nanocarrier	NOUN
admet-3091	330	7	:	:	PUNCT
admet-3091	330	8	bioengineered	bioengineere	VERB
admet-3091	330	9	peptide	peptide	NOUN
admet-3091	330	10	delivery	delivery	NOUN
admet-3091	330	11	systems	system	NOUN
admet-3091	330	12	for	for	ADP
admet-3091	330	13	enhanced	enhanced	ADJ
admet-3091	330	14	wound	wound	NOUN
admet-3091	330	15	healing	healing	NOUN
admet-3091	330	16	.	.	PUNCT
admet-3091	331	1	international	international	ADJ
admet-3091	331	2	journal	journal	PROPN
admet-3091	331	3	of	of	ADP
admet-3091	331	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	331	5	677	677	NUM
admet-3091	331	6	(	(	PUNCT
admet-3091	331	7	2025	2025	NUM
admet-3091	331	8	)	)	PUNCT
admet-3091	331	9	125668	125668	NUM
admet-3091	331	10	.	.	PUNCT
admet-3091	332	1	https://doi.org/10.1016/j.ijpharm.2025.125668	https://doi.org/10.1016/j.ijpharm.2025.125668	VERB
admet-3091	332	2	[	[	X
admet-3091	332	3	22	22	NUM
admet-3091	332	4	]	]	X
admet-3091	332	5	f.y	f.y	PROPN
admet-3091	332	6	.	.	PROPN
admet-3091	332	7	han	han	PROPN
admet-3091	332	8	,	,	PUNCT
admet-3091	332	9	w.	w.	PROPN
admet-3091	332	10	xu	xu	PROPN
admet-3091	332	11	,	,	PUNCT
admet-3091	332	12	v.	v.	PROPN
admet-3091	332	13	kumar	kumar	PROPN
admet-3091	332	14	,	,	PUNCT
admet-3091	332	15	c.s	c.s	PROPN
admet-3091	332	16	.	.	PROPN
admet-3091	332	17	cui	cui	PROPN
admet-3091	332	18	,	,	PUNCT
admet-3091	332	19	x.	x.	PROPN
admet-3091	332	20	li	li	PROPN
admet-3091	332	21	,	,	PUNCT
admet-3091	332	22	x.	x.	PROPN
admet-3091	332	23	jiang	jiang	PROPN
admet-3091	332	24	,	,	PUNCT
admet-3091	332	25	t.m	t.m	PROPN
admet-3091	332	26	.	.	PROPN
admet-3091	332	27	woodruff	woodruff	PROPN
admet-3091	332	28	,	,	PUNCT
admet-3091	332	29	a.k	a.k	PROPN
admet-3091	332	30	.	.	PROPN
admet-3091	332	31	whittaker	whittaker	PROPN
admet-3091	332	32	,	,	PUNCT
admet-3091	332	33	m.t	m.t	PROPN
admet-3091	332	34	.	.	PROPN
admet-3091	332	35	smith	smith	PROPN
admet-3091	332	36	.	.	PUNCT
admet-3091	333	1	optimisation	optimisation	NOUN
admet-3091	333	2	of	of	ADP
admet-3091	333	3	a	a	DET
admet-3091	333	4	microfluidic	microfluidic	ADJ
admet-3091	333	5	method	method	NOUN
admet-3091	333	6	for	for	ADP
admet-3091	333	7	the	the	DET
admet-3091	333	8	delivery	delivery	NOUN
admet-3091	333	9	of	of	ADP
admet-3091	333	10	a	a	DET
admet-3091	333	11	small	small	ADJ
admet-3091	333	12	peptide	peptide	NOUN
admet-3091	333	13	.	.	PUNCT
admet-3091	334	1	pharmaceutics	pharmaceutic	NOUN
admet-3091	334	2	13	13	NUM
admet-3091	334	3	(	(	PUNCT
admet-3091	334	4	2021	2021	NUM
admet-3091	334	5	)	)	PUNCT
admet-3091	334	6	1505	1505	NUM
admet-3091	334	7	.	.	PUNCT
admet-3091	335	1	https://doi.org/10.3390/pharmaceutics13091505	https://doi.org/10.3390/pharmaceutics13091505	PROPN
admet-3091	335	2	https://doi.org/10.1002/wnan.1516	https://doi.org/10.1002/wnan.1516	VERB
admet-3091	335	3	https://doi.org/10.1016/j.jconrel.2005.10.005	https://doi.org/10.1016/j.jconrel.2005.10.005	PROPN
admet-3091	335	4	https://doi.org/10.3390/polym16182606	https://doi.org/10.3390/polym16182606	ADJ
admet-3091	335	5	https://doi.org/10.1016/j.ijpharm.2021.120450	https://doi.org/10.1016/j.ijpharm.2021.120450	PROPN
admet-3091	335	6	https://doi.org/10.1016/j.ijpharm.2006.09.033	https://doi.org/10.1016/j.ijpharm.2006.09.033	VERB
admet-3091	335	7	https://doi.org/10.1517/14712598.7.9.1427	https://doi.org/10.1517/14712598.7.9.1427	PUNCT
admet-3091	336	1	https://doi.org/10.1039/c5tb00515a	https://doi.org/10.1039/c5tb00515a	PROPN
admet-3091	336	2	https://doi.org/10.1016/j.jcis.2022.05.007	https://doi.org/10.1016/j.jcis.2022.05.007	PROPN
admet-3091	336	3	https://doi.org/10.1016/s0939-6411(00)00099-0	https://doi.org/10.1016/s0939-6411(00)00099-0	NOUN
admet-3091	336	4	https://doi.org/10.1016/j.actbio.2019.07.054	https://doi.org/10.1016/j.actbio.2019.07.054	PROPN
admet-3091	336	5	https://doi.org/10.3390/pharmaceutics14020359	https://doi.org/10.3390/pharmaceutics14020359	INTJ
admet-3091	336	6	https://doi.org/10.1080/21645515.2015.1102804	https://doi.org/10.1080/21645515.2015.1102804	X
admet-3091	337	1	https://doi.org/10.1021/acsbiomaterials.0c01228	https://doi.org/10.1021/acsbiomaterials.0c01228	PROPN
admet-3091	337	2	https://doi.org/10.1016/j.jconrel.2017.06.030	https://doi.org/10.1016/j.jconrel.2017.06.030	PROPN
admet-3091	337	3	https://doi.org/10.1016/j.ijpharm.2025.125668	https://doi.org/10.1016/j.ijpharm.2025.125668	PROPN
admet-3091	337	4	https://doi.org/10.3390/pharmaceutics13091505	https://doi.org/10.3390/pharmaceutics13091505	PROPN
admet-3091	337	5	admet	admet	PROPN
admet-3091	337	6	&	&	CCONJ
admet-3091	337	7	dmpk	dmpk	PROPN
admet-3091	337	8	00(0	00(0	PROPN
admet-3091	337	9	)	)	PUNCT
admet-3091	337	10	(	(	PUNCT
admet-3091	337	11	2025	2025	NUM
admet-3091	337	12	)	)	PUNCT
admet-3091	337	13	3091	3091	NUM
admet-3091	337	14	plga	plga	NOUN
admet-3091	337	15	nanoparticles	nanoparticle	NOUN
admet-3091	337	16	and	and	CCONJ
admet-3091	337	17	microparticles	microparticle	NOUN
admet-3091	337	18	for	for	ADP
admet-3091	337	19	peptide	peptide	ADJ
admet-3091	337	20	delivery	delivery	NOUN
admet-3091	337	21	doi	doi	NOUN
admet-3091	337	22	:	:	PUNCT
admet-3091	337	23	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	337	24	15	15	NUM
admet-3091	338	1	[	[	X
admet-3091	338	2	23	23	NUM
admet-3091	338	3	]	]	X
admet-3091	338	4	h.a.d.m	h.a.d.m	PROPN
admet-3091	338	5	.	.	PUNCT
admet-3091	339	1	abu	abu	PROPN
admet-3091	339	2	-	-	PUNCT
admet-3091	339	3	awwad	awwad	PROPN
admet-3091	339	4	,	,	PUNCT
admet-3091	339	5	l.	l.	PROPN
admet-3091	339	6	thiagarajan	thiagarajan	PROPN
admet-3091	339	7	,	,	PUNCT
admet-3091	339	8	j.e	j.e	PROPN
admet-3091	339	9	.	.	PROPN
admet-3091	339	10	dixon	dixon	PROPN
admet-3091	339	11	.	.	PUNCT
admet-3091	339	12	controlled	control	VERB
admet-3091	339	13	release	release	NOUN
admet-3091	339	14	of	of	ADP
admet-3091	339	15	gag	gag	NOUN
admet-3091	339	16	-	-	PUNCT
admet-3091	339	17	binding	bind	VERB
admet-3091	339	18	enhanced	enhance	VERB
admet-3091	339	19	transduction	transduction	NOUN
admet-3091	339	20	(	(	PUNCT
admet-3091	339	21	get	get	VERB
admet-3091	339	22	)	)	PUNCT
admet-3091	339	23	peptides	peptide	NOUN
admet-3091	339	24	for	for	ADP
admet-3091	339	25	sustained	sustained	ADJ
admet-3091	339	26	and	and	CCONJ
admet-3091	339	27	highly	highly	ADV
admet-3091	339	28	efficient	efficient	ADJ
admet-3091	339	29	intracellular	intracellular	ADJ
admet-3091	339	30	delivery	delivery	NOUN
admet-3091	339	31	.	.	PUNCT
admet-3091	340	1	acta	acta	PROPN
admet-3091	340	2	biomaterialia	biomaterialia	PROPN
admet-3091	340	3	57	57	NUM
admet-3091	340	4	(	(	PUNCT
admet-3091	340	5	2017	2017	NUM
admet-3091	340	6	)	)	PUNCT
admet-3091	340	7	225	225	NUM
admet-3091	340	8	-	-	SYM
admet-3091	340	9	237	237	NUM
admet-3091	340	10	.	.	PUNCT
admet-3091	341	1	https://doi.org/10.1016/j.actbio.2017.04.028	https://doi.org/10.1016/j.actbio.2017.04.028	PROPN
admet-3091	342	1	[	[	X
admet-3091	342	2	24	24	NUM
admet-3091	342	3	]	]	X
admet-3091	342	4	a.g	a.g	PROPN
admet-3091	342	5	.	.	PROPN
admet-3091	342	6	ding	ding	PROPN
admet-3091	342	7	,	,	PUNCT
admet-3091	342	8	s.p	s.p	PROPN
admet-3091	342	9	.	.	PROPN
admet-3091	342	10	schwendeman	schwendeman	NOUN
admet-3091	342	11	.	.	PUNCT
admet-3091	343	1	acidic	acidic	ADJ
admet-3091	343	2	microclimate	microclimate	NOUN
admet-3091	343	3	ph	ph	ADJ
admet-3091	343	4	distribution	distribution	NOUN
admet-3091	343	5	in	in	ADP
admet-3091	343	6	plga	plga	NOUN
admet-3091	343	7	microspheres	microsphere	NOUN
admet-3091	343	8	monitored	monitor	VERB
admet-3091	343	9	by	by	ADP
admet-3091	343	10	confocal	confocal	ADJ
admet-3091	343	11	laser	laser	NOUN
admet-3091	343	12	scanning	scan	VERB
admet-3091	343	13	microscopy	microscopy	NOUN
admet-3091	343	14	.	.	PUNCT
admet-3091	344	1	pharmaceutical	pharmaceutical	ADJ
admet-3091	344	2	research	research	NOUN
admet-3091	344	3	25	25	NUM
admet-3091	344	4	(	(	PUNCT
admet-3091	344	5	2008	2008	NUM
admet-3091	344	6	)	)	PUNCT
admet-3091	344	7	2041	2041	NUM
admet-3091	344	8	-	-	SYM
admet-3091	344	9	2052	2052	NUM
admet-3091	344	10	.	.	PUNCT
admet-3091	345	1	https://doi.org/10.1007/s11095-008-9594-3	https://doi.org/10.1007/s11095-008-9594-3	NUM
admet-3091	346	1	[	[	X
admet-3091	346	2	25	25	NUM
admet-3091	346	3	]	]	X
admet-3091	346	4	r.c	r.c	PROPN
admet-3091	346	5	.	.	PROPN
admet-3091	346	6	mundargi	mundargi	PROPN
admet-3091	346	7	,	,	PUNCT
admet-3091	346	8	v.r	v.r	PROPN
admet-3091	346	9	.	.	PROPN
admet-3091	346	10	babu	babu	PROPN
admet-3091	346	11	,	,	PUNCT
admet-3091	346	12	v.rangaswamy	v.rangaswamy	ADJ
admet-3091	346	13	,	,	PUNCT
admet-3091	346	14	p.	p.	NOUN
admet-3091	346	15	patel	patel	PROPN
admet-3091	346	16	,	,	PUNCT
admet-3091	346	17	and	and	CCONJ
admet-3091	346	18	t.m	t.m	PROPN
admet-3091	346	19	.	.	PROPN
admet-3091	346	20	aminabhavi	aminabhavi	PROPN
admet-3091	346	21	.	.	PUNCT
admet-3091	347	1	nano	nano	NOUN
admet-3091	347	2	/	/	SYM
admet-3091	347	3	micro	micro	NOUN
admet-3091	347	4	technologies	technology	NOUN
admet-3091	347	5	for	for	ADP
admet-3091	347	6	delivering	deliver	VERB
admet-3091	347	7	macromolecular	macromolecular	ADJ
admet-3091	347	8	therapeutics	therapeutic	NOUN
admet-3091	347	9	using	use	VERB
admet-3091	347	10	poly	poly	ADJ
admet-3091	347	11	(	(	PUNCT
admet-3091	347	12	d	d	NOUN
admet-3091	347	13	,	,	PUNCT
admet-3091	347	14	l	l	ADJ
admet-3091	347	15	-	-	ADJ
admet-3091	347	16	lactide	lactide	NOUN
admet-3091	347	17	-	-	PUNCT
admet-3091	347	18	co	co	NOUN
admet-3091	347	19	-	-	NOUN
admet-3091	347	20	glycolide	glycolide	ADJ
admet-3091	347	21	)	)	PUNCT
admet-3091	347	22	and	and	CCONJ
admet-3091	347	23	its	its	PRON
admet-3091	347	24	derivatives	derivative	NOUN
admet-3091	347	25	.	.	PUNCT
admet-3091	348	1	journal	journal	PROPN
admet-3091	348	2	of	of	ADP
admet-3091	348	3	controlled	control	VERB
admet-3091	348	4	release	release	NOUN
admet-3091	348	5	125	125	NUM
admet-3091	348	6	(	(	PUNCT
admet-3091	348	7	2008	2008	NUM
admet-3091	348	8	)	)	PUNCT
admet-3091	348	9	193	193	NUM
admet-3091	348	10	-	-	SYM
admet-3091	348	11	209	209	NUM
admet-3091	348	12	.	.	PUNCT
admet-3091	349	1	https://doi.org/10.1016/j.jconrel.2007.09.013	https://doi.org/10.1016/j.jconrel.2007.09.013	PROPN
admet-3091	349	2	[	[	X
admet-3091	349	3	26	26	NUM
admet-3091	349	4	]	]	X
admet-3091	349	5	a.f	a.f	PROPN
admet-3091	349	6	.	.	PROPN
admet-3091	349	7	soares	soares	PROPN
admet-3091	349	8	,	,	PUNCT
admet-3091	349	9	r.d.a	r.d.a	NOUN
admet-3091	349	10	.	.	PUNCT
admet-3091	349	11	carvalho	carvalho	PROPN
admet-3091	349	12	,	,	PUNCT
admet-3091	349	13	f.	f.	PROPN
admet-3091	349	14	veiga	veiga	PROPN
admet-3091	349	15	.	.	PUNCT
admet-3091	350	1	oral	oral	ADJ
admet-3091	350	2	administration	administration	NOUN
admet-3091	350	3	of	of	ADP
admet-3091	350	4	peptides	peptide	NOUN
admet-3091	350	5	and	and	CCONJ
admet-3091	350	6	proteins	protein	NOUN
admet-3091	350	7	:	:	PUNCT
admet-3091	350	8	nanoparticles	nanoparticle	NOUN
admet-3091	350	9	and	and	CCONJ
admet-3091	350	10	cyclodextrins	cyclodextrin	NOUN
admet-3091	350	11	as	as	ADP
admet-3091	350	12	biocompatible	biocompatible	ADJ
admet-3091	350	13	delivery	delivery	NOUN
admet-3091	350	14	systems	system	NOUN
admet-3091	350	15	.	.	PUNCT
admet-3091	351	1	nanomedicine	nanomedicine	NOUN
admet-3091	351	2	2	2	NUM
admet-3091	351	3	(	(	PUNCT
admet-3091	351	4	2007	2007	NUM
admet-3091	351	5	)	)	PUNCT
admet-3091	351	6	183	183	NUM
admet-3091	351	7	-	-	SYM
admet-3091	351	8	202	202	NUM
admet-3091	351	9	.	.	PUNCT
admet-3091	351	10	https://doi.org/10.2217/17435889.2.2.183	https://doi.org/10.2217/17435889.2.2.183	NOUN
admet-3091	352	1	[	[	X
admet-3091	352	2	27	27	NUM
admet-3091	352	3	]	]	PUNCT
admet-3091	352	4	t.	t.	PROPN
admet-3091	352	5	akagi	akagi	PROPN
admet-3091	352	6	,	,	PUNCT
admet-3091	352	7	m.	m.	NOUN
admet-3091	352	8	baba	baba	PROPN
admet-3091	352	9	,	,	PUNCT
admet-3091	352	10	m.	m.	PROPN
admet-3091	352	11	akashi	akashi	PROPN
admet-3091	352	12	.	.	PUNCT
admet-3091	353	1	biodegradable	biodegradable	ADJ
admet-3091	353	2	nanoparticles	nanoparticle	NOUN
admet-3091	353	3	as	as	ADP
admet-3091	353	4	vaccine	vaccine	NOUN
admet-3091	353	5	adjuvants	adjuvant	NOUN
admet-3091	353	6	and	and	CCONJ
admet-3091	353	7	delivery	delivery	NOUN
admet-3091	353	8	systems	system	NOUN
admet-3091	353	9	:	:	PUNCT
admet-3091	353	10	regulation	regulation	NOUN
admet-3091	353	11	of	of	ADP
admet-3091	353	12	immune	immune	ADJ
admet-3091	353	13	responses	response	NOUN
admet-3091	353	14	by	by	ADP
admet-3091	353	15	nanoparticle	nanoparticle	NOUN
admet-3091	353	16	-	-	PUNCT
admet-3091	353	17	based	base	VERB
admet-3091	353	18	vaccine	vaccine	NOUN
admet-3091	353	19	.	.	PUNCT
admet-3091	354	1	polymers	polymer	NOUN
admet-3091	354	2	in	in	ADP
admet-3091	354	3	nanomedicine	nanomedicine	NOUN
admet-3091	354	4	247	247	NUM
admet-3091	354	5	(	(	PUNCT
admet-3091	354	6	2012	2012	NUM
admet-3091	354	7	)	)	PUNCT
admet-3091	354	8	31	31	NUM
admet-3091	354	9	-	-	SYM
admet-3091	354	10	64	64	NUM
admet-3091	354	11	.	.	PUNCT
admet-3091	354	12	https://doi.org/10.1007/12_2011_150	https://doi.org/10.1007/12_2011_150	VERB
admet-3091	355	1	[	[	X
admet-3091	355	2	28	28	NUM
admet-3091	355	3	]	]	X
admet-3091	355	4	d.	d.	PROPN
admet-3091	355	5	palmer	palmer	PROPN
admet-3091	355	6	,	,	PUNCT
admet-3091	355	7	k.	k.	PROPN
admet-3091	355	8	bamsey	bamsey	PROPN
admet-3091	355	9	,	,	PUNCT
admet-3091	355	10	r.	r.	NOUN
admet-3091	355	11	groves	grove	NOUN
admet-3091	355	12	,	,	PUNCT
admet-3091	355	13	p.	p.	NOUN
admet-3091	355	14	patil	patil	PROPN
admet-3091	355	15	,	,	PUNCT
admet-3091	355	16	h.	h.	PROPN
admet-3091	355	17	jones	jones	PROPN
admet-3091	355	18	,	,	PUNCT
admet-3091	355	19	l.	l.	PROPN
admet-3091	355	20	mcaleer	mcaleer	PROPN
admet-3091	355	21	,	,	PUNCT
admet-3091	355	22	p.	p.	NOUN
admet-3091	355	23	seaman	seaman	NOUN
admet-3091	355	24	.	.	PUNCT
admet-3091	356	1	printing	print	VERB
admet-3091	356	2	particles	particle	NOUN
admet-3091	356	3	:	:	PUNCT
admet-3091	356	4	a	a	DET
admet-3091	356	5	highthroughput	highthroughput	NOUN
admet-3091	356	6	technique	technique	NOUN
admet-3091	356	7	for	for	ADP
admet-3091	356	8	the	the	DET
admet-3091	356	9	production	production	NOUN
admet-3091	356	10	of	of	ADP
admet-3091	356	11	uniform	uniform	ADJ
admet-3091	356	12	,	,	PUNCT
admet-3091	356	13	bioresorbable	bioresorbable	ADJ
admet-3091	356	14	polymer	polymer	NOUN
admet-3091	356	15	microparticles	microparticle	NOUN
admet-3091	356	16	and	and	CCONJ
admet-3091	356	17	encapsulation	encapsulation	NOUN
admet-3091	356	18	of	of	ADP
admet-3091	356	19	therapeutic	therapeutic	ADJ
admet-3091	356	20	peptides	peptide	NOUN
admet-3091	356	21	.	.	PUNCT
admet-3091	357	1	chemical	chemical	NOUN
admet-3091	357	2	engineering	engineering	NOUN
admet-3091	357	3	science	science	NOUN
admet-3091	357	4	166	166	NUM
admet-3091	357	5	(	(	PUNCT
admet-3091	357	6	2017	2017	NUM
admet-3091	357	7	)	)	PUNCT
admet-3091	357	8	122	122	NUM
admet-3091	357	9	-	-	SYM
admet-3091	357	10	129	129	NUM
admet-3091	357	11	.	.	PUNCT
admet-3091	358	1	https://doi.org/10.1016/j.ces.2017.03.038	https://doi.org/10.1016/j.ces.2017.03.038	VERB
admet-3091	359	1	[	[	X
admet-3091	359	2	29	29	NUM
admet-3091	359	3	]	]	X
admet-3091	359	4	c.	c.	PROPN
admet-3091	359	5	gujral	gujral	PROPN
admet-3091	359	6	,	,	PUNCT
admet-3091	359	7	y.	y.	PROPN
admet-3091	359	8	minagawa	minagawa	PROPN
admet-3091	359	9	,	,	PUNCT
admet-3091	359	10	k.	k.	PROPN
admet-3091	359	11	fujimoto	fujimoto	PROPN
admet-3091	359	12	,	,	PUNCT
admet-3091	359	13	h.	h.	PROPN
admet-3091	359	14	kitano	kitano	PROPN
admet-3091	359	15	,	,	PUNCT
admet-3091	359	16	t.	t.	PROPN
admet-3091	359	17	nakaji	nakaji	PROPN
admet-3091	359	18	-	-	PUNCT
admet-3091	359	19	hirabayashi	hirabayashi	PROPN
admet-3091	359	20	.	.	PUNCT
admet-3091	360	1	biodegradable	biodegradable	ADJ
admet-3091	360	2	microparticles	microparticle	NOUN
admet-3091	360	3	for	for	ADP
admet-3091	360	4	strictly	strictly	ADV
admet-3091	360	5	regulating	regulate	VERB
admet-3091	360	6	the	the	DET
admet-3091	360	7	release	release	NOUN
admet-3091	360	8	of	of	ADP
admet-3091	360	9	neurotrophic	neurotrophic	ADJ
admet-3091	360	10	factors	factor	NOUN
admet-3091	360	11	.	.	PUNCT
admet-3091	361	1	journal	journal	NOUN
admet-3091	361	2	of	of	ADP
admet-3091	361	3	controlled	control	VERB
admet-3091	361	4	release	release	NOUN
admet-3091	361	5	168	168	NUM
admet-3091	361	6	(	(	PUNCT
admet-3091	361	7	2013	2013	NUM
admet-3091	361	8	)	)	PUNCT
admet-3091	361	9	307316	307316	NUM
admet-3091	361	10	.	.	PUNCT
admet-3091	362	1	https://doi.org/10.1016/j.jconrel.2013.03.031	https://doi.org/10.1016/j.jconrel.2013.03.031	NOUN
admet-3091	362	2	[	[	X
admet-3091	362	3	30	30	NUM
admet-3091	362	4	]	]	X
admet-3091	362	5	y.w	y.w	PROPN
admet-3091	362	6	.	.	PROPN
admet-3091	362	7	lim	lim	PROPN
admet-3091	362	8	,	,	PUNCT
admet-3091	362	9	w.s	w.s	PROPN
admet-3091	362	10	.	.	PROPN
admet-3091	362	11	tan	tan	PROPN
admet-3091	362	12	,	,	PUNCT
admet-3091	362	13	k.l	k.l	PROPN
admet-3091	362	14	.	.	PROPN
admet-3091	362	15	ho	ho	PROPN
admet-3091	362	16	,	,	PUNCT
admet-3091	362	17	a.r	a.r	PROPN
admet-3091	362	18	.	.	PROPN
admet-3091	362	19	mariatulqabtiah	mariatulqabtiah	PROPN
admet-3091	362	20	,	,	PUNCT
admet-3091	362	21	n.h	n.h	PROPN
admet-3091	362	22	.	.	PUNCT
admet-3091	363	1	abu	abu	PROPN
admet-3091	363	2	kasim	kasim	PROPN
admet-3091	363	3	,	,	PUNCT
admet-3091	363	4	n.abd	n.abd	PROPN
admet-3091	363	5	.	.	PUNCT
admet-3091	364	1	rahman	rahman	PROPN
admet-3091	364	2	,	,	PUNCT
admet-3091	364	3	t.w	t.w	PROPN
admet-3091	364	4	.	.	PROPN
admet-3091	364	5	wong	wong	PROPN
admet-3091	364	6	,	,	PUNCT
admet-3091	364	7	c.f	c.f	PROPN
admet-3091	364	8	.	.	PROPN
admet-3091	364	9	chee	chee	NOUN
admet-3091	364	10	.	.	PUNCT
admet-3091	365	1	challenges	challenge	NOUN
admet-3091	365	2	and	and	CCONJ
admet-3091	365	3	complications	complication	NOUN
admet-3091	365	4	of	of	ADP
admet-3091	365	5	poly	poly	ADJ
admet-3091	365	6	(	(	PUNCT
admet-3091	365	7	lactic	lactic	NOUN
admet-3091	365	8	-	-	PUNCT
admet-3091	365	9	co	co	NOUN
admet-3091	365	10	-	-	ADJ
admet-3091	365	11	glycolic	glycolic	ADJ
admet-3091	365	12	acid)-based	acid)-base	VERB
admet-3091	365	13	long	long	ADV
admet-3091	365	14	-	-	PUNCT
admet-3091	365	15	acting	act	VERB
admet-3091	365	16	drug	drug	NOUN
admet-3091	365	17	product	product	NOUN
admet-3091	365	18	development	development	NOUN
admet-3091	365	19	.	.	PUNCT
admet-3091	366	1	pharmaceutics	pharmaceutic	NOUN
admet-3091	366	2	14	14	NUM
admet-3091	366	3	(	(	PUNCT
admet-3091	366	4	2022	2022	NUM
admet-3091	366	5	)	)	PUNCT
admet-3091	366	6	614	614	NUM
admet-3091	366	7	.	.	PUNCT
admet-3091	367	1	https://doi.org/10.3390/pharmaceutics14030614	https://doi.org/10.3390/pharmaceutics14030614	PUNCT
admet-3091	368	1	[	[	X
admet-3091	368	2	31	31	NUM
admet-3091	368	3	]	]	X
admet-3091	368	4	r.f	r.f	PROPN
admet-3091	368	5	.	.	PROPN
admet-3091	368	6	pagels	pagels	PROPN
admet-3091	368	7	,	,	PUNCT
admet-3091	368	8	r.k	r.k	PROPN
admet-3091	368	9	.	.	PROPN
admet-3091	368	10	prud'homme	prud'homme	PROPN
admet-3091	368	11	.	.	PUNCT
admet-3091	369	1	polymeric	polymeric	ADJ
admet-3091	369	2	nanoparticles	nanoparticle	NOUN
admet-3091	369	3	and	and	CCONJ
admet-3091	369	4	microparticles	microparticle	NOUN
admet-3091	369	5	for	for	ADP
admet-3091	369	6	the	the	DET
admet-3091	369	7	delivery	delivery	NOUN
admet-3091	369	8	of	of	ADP
admet-3091	369	9	peptides	peptide	NOUN
admet-3091	369	10	,	,	PUNCT
admet-3091	369	11	biologics	biologic	NOUN
admet-3091	369	12	,	,	PUNCT
admet-3091	369	13	and	and	CCONJ
admet-3091	369	14	soluble	soluble	ADJ
admet-3091	369	15	therapeutics	therapeutic	NOUN
admet-3091	369	16	.	.	PUNCT
admet-3091	370	1	journal	journal	PROPN
admet-3091	370	2	of	of	ADP
admet-3091	370	3	controlled	control	VERB
admet-3091	370	4	release	release	NOUN
admet-3091	370	5	219	219	NUM
admet-3091	370	6	(	(	PUNCT
admet-3091	370	7	2015	2015	NUM
admet-3091	370	8	)	)	PUNCT
admet-3091	370	9	519	519	NUM
admet-3091	370	10	-	-	SYM
admet-3091	370	11	535	535	NUM
admet-3091	370	12	.	.	PUNCT
admet-3091	371	1	https://doi.org/10.1016/j.jconrel.2015.09.001	https://doi.org/10.1016/j.jconrel.2015.09.001	PRON
admet-3091	371	2	[	[	X
admet-3091	371	3	32	32	NUM
admet-3091	371	4	]	]	X
admet-3091	371	5	y.a	y.a	PROPN
admet-3091	371	6	.	.	PROPN
admet-3091	371	7	haggag	haggag	PROPN
admet-3091	371	8	,	,	PUNCT
admet-3091	371	9	k.b	k.b	PROPN
admet-3091	371	10	.	.	PROPN
admet-3091	371	11	matchett	matchett	PROPN
admet-3091	371	12	,	,	PUNCT
admet-3091	371	13	e.h	e.h	PROPN
admet-3091	371	14	.	.	PROPN
admet-3091	371	15	dakir	dakir	PROPN
admet-3091	371	16	,	,	PUNCT
admet-3091	371	17	p.	p.	PROPN
admet-3091	371	18	buchanan	buchanan	PROPN
admet-3091	371	19	,	,	PUNCT
admet-3091	371	20	m.a	m.a	PROPN
admet-3091	371	21	.	.	PROPN
admet-3091	371	22	osman	osman	PROPN
admet-3091	371	23	,	,	PUNCT
admet-3091	371	24	s.a	s.a	PROPN
admet-3091	371	25	.	.	PROPN
admet-3091	371	26	elgizawy	elgizawy	PROPN
admet-3091	371	27	,	,	PUNCT
admet-3091	371	28	m.	m.	PROPN
admet-3091	371	29	el	el	PROPN
admet-3091	371	30	-	-	PUNCT
admet-3091	371	31	tanani	tanani	PROPN
admet-3091	371	32	,	,	PUNCT
admet-3091	371	33	a.m.	a.m.	PROPN
admet-3091	371	34	faheem	faheem	PROPN
admet-3091	371	35	,	,	PUNCT
admet-3091	371	36	p.a	p.a	PROPN
admet-3091	371	37	.	.	PUNCT
admet-3091	371	38	mccarron	mccarron	PROPN
admet-3091	371	39	.	.	PUNCT
admet-3091	372	1	nano	nano	NOUN
admet-3091	372	2	-	-	PUNCT
admet-3091	372	3	encapsulation	encapsulation	NOUN
admet-3091	372	4	of	of	ADP
admet-3091	372	5	a	a	DET
admet-3091	372	6	novel	novel	ADJ
admet-3091	372	7	anti	anti	ADJ
admet-3091	372	8	-	-	ADJ
admet-3091	372	9	ran	ran	ADJ
admet-3091	372	10	-	-	PUNCT
admet-3091	372	11	gtpase	gtpase	NOUN
admet-3091	372	12	peptide	peptide	NOUN
admet-3091	372	13	for	for	ADP
admet-3091	372	14	blockade	blockade	NOUN
admet-3091	372	15	of	of	ADP
admet-3091	372	16	regulator	regulator	NOUN
admet-3091	372	17	of	of	ADP
admet-3091	372	18	chromosome	chromosome	NOUN
admet-3091	372	19	condensation	condensation	NOUN
admet-3091	372	20	1	1	NUM
admet-3091	372	21	(	(	PUNCT
admet-3091	372	22	rcc1	rcc1	NOUN
admet-3091	372	23	)	)	PUNCT
admet-3091	372	24	function	function	NOUN
admet-3091	372	25	in	in	ADP
admet-3091	372	26	mda	mda	PROPN
admet-3091	372	27	-	-	PUNCT
admet-3091	372	28	mb-231	mb-231	PROPN
admet-3091	372	29	breast	breast	NOUN
admet-3091	372	30	cancer	cancer	NOUN
admet-3091	372	31	cells	cell	NOUN
admet-3091	372	32	.	.	PUNCT
admet-3091	373	1	international	international	ADJ
admet-3091	373	2	journal	journal	PROPN
admet-3091	373	3	of	of	ADP
admet-3091	373	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	373	5	521	521	NUM
admet-3091	373	6	(	(	PUNCT
admet-3091	373	7	2017	2017	NUM
admet-3091	373	8	)	)	PUNCT
admet-3091	373	9	40	40	NUM
admet-3091	373	10	-	-	SYM
admet-3091	373	11	53	53	NUM
admet-3091	373	12	.	.	PUNCT
admet-3091	374	1	https://doi.org/10.1016/j.ijpharm.2017.02.006	https://doi.org/10.1016/j.ijpharm.2017.02.006	NUM
admet-3091	374	2	[	[	PUNCT
admet-3091	374	3	33	33	NUM
admet-3091	374	4	]	]	X
admet-3091	374	5	e.l	e.l	PROPN
admet-3091	374	6	.	.	PROPN
admet-3091	374	7	hedberg	hedberg	PROPN
admet-3091	374	8	,	,	PUNCT
admet-3091	374	9	a.	a.	PROPN
admet-3091	374	10	tang	tang	PROPN
admet-3091	374	11	,	,	PUNCT
admet-3091	374	12	r.s	r.s	PROPN
admet-3091	374	13	.	.	PROPN
admet-3091	374	14	crowther	crowther	PROPN
admet-3091	374	15	,	,	PUNCT
admet-3091	374	16	d.h	d.h	PROPN
admet-3091	374	17	.	.	PROPN
admet-3091	374	18	carney	carney	PROPN
admet-3091	374	19	,	,	PUNCT
admet-3091	374	20	a.g	a.g	PROPN
admet-3091	374	21	.	.	PROPN
admet-3091	374	22	mikos	mikos	PROPN
admet-3091	374	23	.	.	PUNCT
admet-3091	375	1	controlled	control	VERB
admet-3091	375	2	release	release	NOUN
admet-3091	375	3	of	of	ADP
admet-3091	375	4	an	an	DET
admet-3091	375	5	osteogenic	osteogenic	ADJ
admet-3091	375	6	peptide	peptide	NOUN
admet-3091	375	7	from	from	ADP
admet-3091	375	8	injectable	injectable	ADJ
admet-3091	375	9	biodegradable	biodegradable	ADJ
admet-3091	375	10	polymeric	polymeric	ADJ
admet-3091	375	11	composites	composite	NOUN
admet-3091	375	12	.	.	PUNCT
admet-3091	376	1	journal	journal	PROPN
admet-3091	376	2	of	of	ADP
admet-3091	376	3	controlled	control	VERB
admet-3091	376	4	release	release	NOUN
admet-3091	376	5	84	84	NUM
admet-3091	376	6	(	(	PUNCT
admet-3091	376	7	2002	2002	NUM
admet-3091	376	8	)	)	PUNCT
admet-3091	376	9	137	137	NUM
admet-3091	376	10	-	-	SYM
admet-3091	376	11	150	150	NUM
admet-3091	376	12	.	.	PUNCT
admet-3091	377	1	https://doi.org/10.1016/s0168-3659(02)00261-4	https://doi.org/10.1016/s0168-3659(02)00261-4	PROPN
admet-3091	378	1	[	[	X
admet-3091	378	2	34	34	NUM
admet-3091	378	3	]	]	X
admet-3091	378	4	j.j	j.j	PROPN
admet-3091	378	5	.	.	PROPN
admet-3091	378	6	water	water	PROPN
admet-3091	378	7	,	,	PUNCT
admet-3091	378	8	s.	s.	PROPN
admet-3091	378	9	smart	smart	PROPN
admet-3091	378	10	,	,	PUNCT
admet-3091	378	11	h.	h.	PROPN
admet-3091	378	12	franzyk	franzyk	PROPN
admet-3091	378	13	,	,	PUNCT
admet-3091	378	14	c.	c.	PROPN
admet-3091	378	15	foged	fog	VERB
admet-3091	378	16	,	,	PUNCT
admet-3091	378	17	h.m	h.m	PROPN
admet-3091	378	18	.	.	PROPN
admet-3091	378	19	nielsen	nielsen	PROPN
admet-3091	378	20	.	.	PUNCT
admet-3091	379	1	nanoparticle	nanoparticle	NOUN
admet-3091	379	2	-	-	PUNCT
admet-3091	379	3	mediated	mediate	VERB
admet-3091	379	4	delivery	delivery	NOUN
admet-3091	379	5	of	of	ADP
admet-3091	379	6	the	the	DET
admet-3091	379	7	antimicrobial	antimicrobial	ADJ
admet-3091	379	8	peptide	peptide	NOUN
admet-3091	379	9	plectasin	plectasin	NOUN
admet-3091	379	10	against	against	ADP
admet-3091	379	11	staphylococcus	staphylococcus	NOUN
admet-3091	379	12	aureus	aureus	NOUN
admet-3091	379	13	in	in	ADP
admet-3091	379	14	infected	infected	ADJ
admet-3091	379	15	epithelial	epithelial	ADJ
admet-3091	379	16	cells	cell	NOUN
admet-3091	379	17	.	.	PUNCT
admet-3091	380	1	european	european	ADJ
admet-3091	380	2	journal	journal	PROPN
admet-3091	380	3	of	of	ADP
admet-3091	380	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	380	5	and	and	CCONJ
admet-3091	380	6	biopharmaceutics	biopharmaceutic	NOUN
admet-3091	380	7	92	92	NUM
admet-3091	380	8	(	(	PUNCT
admet-3091	380	9	2015	2015	NUM
admet-3091	380	10	)	)	PUNCT
admet-3091	380	11	65	65	NUM
admet-3091	380	12	-	-	SYM
admet-3091	380	13	73	73	NUM
admet-3091	380	14	.	.	PUNCT
admet-3091	381	1	https://doi.org/10.1016/j.ejpb.2015.02.009	https://doi.org/10.1016/j.ejpb.2015.02.009	NUM
admet-3091	382	1	[	[	X
admet-3091	382	2	35	35	NUM
admet-3091	382	3	]	]	X
admet-3091	382	4	j.	j.	PROPN
admet-3091	382	5	lee	lee	PROPN
admet-3091	382	6	,	,	PUNCT
admet-3091	382	7	y.j	y.j	PROPN
admet-3091	382	8	.	.	PUNCT
admet-3091	383	1	oh	oh	INTJ
admet-3091	383	2	,	,	PUNCT
admet-3091	383	3	s.k	s.k	PROPN
admet-3091	383	4	.	.	PROPN
admet-3091	383	5	lee	lee	PROPN
admet-3091	383	6	,	,	PUNCT
admet-3091	383	7	k.y	k.y	PROPN
admet-3091	383	8	.	.	PROPN
admet-3091	383	9	lee	lee	PROPN
admet-3091	383	10	.	.	PROPN
admet-3091	384	1	facile	facile	ADJ
admet-3091	384	2	control	control	NOUN
admet-3091	384	3	of	of	ADP
admet-3091	384	4	porous	porous	ADJ
admet-3091	384	5	structures	structure	NOUN
admet-3091	384	6	of	of	ADP
admet-3091	384	7	polymer	polymer	NOUN
admet-3091	384	8	microspheres	microsphere	NOUN
admet-3091	384	9	using	use	VERB
admet-3091	384	10	an	an	DET
admet-3091	384	11	osmotic	osmotic	ADJ
admet-3091	384	12	agent	agent	NOUN
admet-3091	384	13	for	for	ADP
admet-3091	384	14	pulmonary	pulmonary	ADJ
admet-3091	384	15	delivery	delivery	NOUN
admet-3091	384	16	.	.	PUNCT
admet-3091	385	1	journal	journal	NOUN
admet-3091	385	2	of	of	ADP
admet-3091	385	3	controlled	control	VERB
admet-3091	385	4	release	release	NOUN
admet-3091	385	5	146	146	NUM
admet-3091	385	6	(	(	PUNCT
admet-3091	385	7	2010	2010	NUM
admet-3091	385	8	)	)	PUNCT
admet-3091	385	9	61	61	NUM
admet-3091	385	10	-	-	SYM
admet-3091	385	11	67	67	NUM
admet-3091	385	12	.	.	PUNCT
admet-3091	386	1	https://doi.org/10.1016/j.jconrel.2010.05.026	https://doi.org/10.1016/j.jconrel.2010.05.026	PROPN
admet-3091	386	2	[	[	X
admet-3091	386	3	36	36	NUM
admet-3091	386	4	]	]	PUNCT
admet-3091	386	5	x.	x.	PROPN
admet-3091	386	6	luan	luan	PROPN
admet-3091	386	7	,	,	PUNCT
admet-3091	386	8	r.	r.	PROPN
admet-3091	386	9	bodmeier	bodmeier	PROPN
admet-3091	386	10	.	.	PUNCT
admet-3091	387	1	modification	modification	NOUN
admet-3091	387	2	of	of	ADP
admet-3091	387	3	the	the	DET
admet-3091	387	4	tri	tri	ADJ
admet-3091	387	5	-	-	ADJ
admet-3091	387	6	phasic	phasic	ADJ
admet-3091	387	7	drug	drug	NOUN
admet-3091	387	8	release	release	NOUN
admet-3091	387	9	pattern	pattern	NOUN
admet-3091	387	10	of	of	ADP
admet-3091	387	11	leuprolide	leuprolide	NOUN
admet-3091	387	12	acetate	acetate	NOUN
admet-3091	387	13	-	-	PUNCT
admet-3091	387	14	loaded	load	VERB
admet-3091	387	15	poly	poly	ADJ
admet-3091	387	16	(	(	PUNCT
admet-3091	387	17	lactide	lactide	NOUN
admet-3091	387	18	-	-	PUNCT
admet-3091	387	19	co	co	NOUN
admet-3091	387	20	-	-	ADJ
admet-3091	387	21	glycolide	glycolide	ADJ
admet-3091	387	22	)	)	PUNCT
admet-3091	387	23	microparticles	microparticle	NOUN
admet-3091	387	24	.	.	PUNCT
admet-3091	388	1	european	european	PROPN
admet-3091	388	2	journal	journal	PROPN
admet-3091	388	3	of	of	ADP
admet-3091	388	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	388	5	and	and	CCONJ
admet-3091	388	6	biopharmaceutics	biopharmaceutic	NOUN
admet-3091	388	7	63	63	NUM
admet-3091	388	8	(	(	PUNCT
admet-3091	388	9	2006	2006	NUM
admet-3091	388	10	)	)	PUNCT
admet-3091	388	11	205	205	NUM
admet-3091	388	12	-	-	SYM
admet-3091	388	13	214	214	NUM
admet-3091	388	14	.	.	PUNCT
admet-3091	389	1	https://doi.org/10.1016/j.ejpb.2005.12.010	https://doi.org/10.1016/j.ejpb.2005.12.010	PROPN
admet-3091	389	2	[	[	X
admet-3091	389	3	37	37	NUM
admet-3091	389	4	]	]	PUNCT
admet-3091	389	5	b.	b.	PROPN
admet-3091	389	6	meng	meng	PROPN
admet-3091	389	7	,	,	PUNCT
admet-3091	389	8	l.	l.	PROPN
admet-3091	389	9	li	li	PROPN
admet-3091	389	10	,	,	PUNCT
admet-3091	389	11	s.	s.	PROPN
admet-3091	389	12	hua	hua	PROPN
admet-3091	389	13	,	,	PUNCT
admet-3091	389	14	q.	q.	PROPN
admet-3091	389	15	wang	wang	PROPN
admet-3091	389	16	,	,	PUNCT
admet-3091	389	17	c.	c.	PROPN
admet-3091	389	18	liu	liu	PROPN
admet-3091	389	19	,	,	PUNCT
admet-3091	389	20	x.	x.	PROPN
admet-3091	389	21	xu	xu	PROPN
admet-3091	389	22	,	,	PUNCT
admet-3091	389	23	x.	x.	PROPN
admet-3091	389	24	yin	yin	PROPN
admet-3091	389	25	.	.	PUNCT
admet-3091	390	1	effect	effect	NOUN
admet-3091	390	2	of	of	ADP
admet-3091	390	3	medium	medium	ADJ
admet-3091	390	4	-	-	PUNCT
admet-3091	390	5	chain	chain	NOUN
admet-3091	390	6	triglycerides	triglyceride	NOUN
admet-3091	390	7	on	on	ADP
admet-3091	390	8	the	the	DET
admet-3091	390	9	release	release	NOUN
admet-3091	390	10	behavior	behavior	NOUN
admet-3091	390	11	of	of	ADP
admet-3091	390	12	endostar	endostar	NOUN
admet-3091	390	13	®	®	NOUN
admet-3091	390	14	encapsulated	encapsulate	VERB
admet-3091	390	15	plga	plga	NOUN
admet-3091	390	16	microspheres	microsphere	NOUN
admet-3091	390	17	.	.	PUNCT
admet-3091	391	1	international	international	ADJ
admet-3091	391	2	journal	journal	PROPN
admet-3091	391	3	of	of	ADP
admet-3091	391	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	391	5	397	397	NUM
admet-3091	391	6	(	(	PUNCT
admet-3091	391	7	2010	2010	NUM
admet-3091	391	8	)	)	PUNCT
admet-3091	391	9	136	136	NUM
admet-3091	391	10	-	-	SYM
admet-3091	391	11	143	143	NUM
admet-3091	391	12	.	.	PUNCT
admet-3091	392	1	https://doi.org/10.1016/j.ijpharm.2010.07.018	https://doi.org/10.1016/j.ijpharm.2010.07.018	NOUN
admet-3091	392	2	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	VERB
admet-3091	392	3	https://doi.org/10.1016/j.actbio.2017.04.028	https://doi.org/10.1016/j.actbio.2017.04.028	PROPN
admet-3091	392	4	https://doi.org/10.1007/s11095-008-9594-3	https://doi.org/10.1007/s11095-008-9594-3	NUM
admet-3091	392	5	https://doi.org/10.1016/j.jconrel.2007.09.013	https://doi.org/10.1016/j.jconrel.2007.09.013	PROPN
admet-3091	392	6	https://doi.org/10.2217/17435889.2.2.183	https://doi.org/10.2217/17435889.2.2.183	NOUN
admet-3091	392	7	https://doi.org/10.1007/12_2011_150	https://doi.org/10.1007/12_2011_150	PROPN
admet-3091	392	8	https://doi.org/10.1016/j.ces.2017.03.038	https://doi.org/10.1016/j.ces.2017.03.038	PROPN
admet-3091	392	9	https://doi.org/10.1016/j.jconrel.2013.03.031	https://doi.org/10.1016/j.jconrel.2013.03.031	NOUN
admet-3091	392	10	https://doi.org/10.3390/pharmaceutics14030614	https://doi.org/10.3390/pharmaceutics14030614	VERB
admet-3091	392	11	https://doi.org/10.1016/j.jconrel.2015.09.001	https://doi.org/10.1016/j.jconrel.2015.09.001	PRON
admet-3091	392	12	https://doi.org/10.1016/j.ijpharm.2017.02.006	https://doi.org/10.1016/j.ijpharm.2017.02.006	NOUN
admet-3091	392	13	https://doi.org/10.1016/s0168-3659(02)00261-4	https://doi.org/10.1016/s0168-3659(02)00261-4	NOUN
admet-3091	392	14	https://doi.org/10.1016/j.ejpb.2015.02.009	https://doi.org/10.1016/j.ejpb.2015.02.009	X
admet-3091	392	15	https://doi.org/10.1016/j.jconrel.2010.05.026	https://doi.org/10.1016/j.jconrel.2010.05.026	PROPN
admet-3091	392	16	https://doi.org/10.1016/j.ejpb.2005.12.010	https://doi.org/10.1016/j.ejpb.2005.12.010	PROPN
admet-3091	392	17	https://doi.org/10.1016/j.ijpharm.2010.07.018	https://doi.org/10.1016/j.ijpharm.2010.07.018	PROPN
admet-3091	393	1	m.	m.	PROPN
admet-3091	393	2	eshaghi	eshaghi	PROPN
admet-3091	393	3	et	et	PROPN
admet-3091	393	4	al	al	PROPN
admet-3091	393	5	.	.	PROPN
admet-3091	393	6	admet	admet	PROPN
admet-3091	393	7	&	&	CCONJ
admet-3091	393	8	dmpk	dmpk	PROPN
admet-3091	393	9	00(0	00(0	PROPN
admet-3091	393	10	)	)	PUNCT
admet-3091	393	11	(	(	PUNCT
admet-3091	393	12	2025	2025	NUM
admet-3091	393	13	)	)	PUNCT
admet-3091	393	14	3091	3091	NUM
admet-3091	393	15	16	16	NUM
admet-3091	394	1	[	[	X
admet-3091	394	2	38	38	NUM
admet-3091	394	3	]	]	PUNCT
admet-3091	394	4	w.	w.	PROPN
admet-3091	394	5	liu	liu	PROPN
admet-3091	394	6	,	,	PUNCT
admet-3091	394	7	a.	a.	PROPN
admet-3091	394	8	yang	yang	PROPN
admet-3091	394	9	,	,	PUNCT
admet-3091	394	10	z.	z.	PROPN
admet-3091	394	11	li	li	PROPN
admet-3091	394	12	,	,	PUNCT
admet-3091	394	13	h.	h.	PROPN
admet-3091	394	14	xu	xu	PROPN
admet-3091	394	15	,	,	PUNCT
admet-3091	394	16	x.	x.	PROPN
admet-3091	394	17	yang	yang	PROPN
admet-3091	394	18	.	.	PROPN
admet-3091	395	1	pegylated	pegylate	VERB
admet-3091	395	2	plga	plga	NOUN
admet-3091	395	3	nanoparticles	nanoparticle	NOUN
admet-3091	395	4	as	as	ADP
admet-3091	395	5	tumor	tumor	NOUN
admet-3091	395	6	necrosis	necrosis	NOUN
admet-3091	395	7	factor	factor	NOUN
admet-3091	395	8	-	-	PUNCT
admet-3091	395	9	α	α	NOUN
admet-3091	395	10	receptor	receptor	NOUN
admet-3091	395	11	blocking	block	VERB
admet-3091	395	12	peptide	peptide	NOUN
admet-3091	395	13	carriers	carrier	NOUN
admet-3091	395	14	:	:	PUNCT
admet-3091	395	15	preparation	preparation	NOUN
admet-3091	395	16	,	,	PUNCT
admet-3091	395	17	characterization	characterization	NOUN
admet-3091	395	18	and	and	CCONJ
admet-3091	395	19	release	release	NOUN
admet-3091	395	20	in	in	ADP
admet-3091	395	21	vitro	vitro	X
admet-3091	395	22	.	.	PUNCT
admet-3091	396	1	journal	journal	PROPN
admet-3091	396	2	of	of	ADP
admet-3091	396	3	wuhan	wuhan	PROPN
admet-3091	396	4	university	university	PROPN
admet-3091	396	5	of	of	ADP
admet-3091	396	6	technology	technology	NOUN
admet-3091	396	7	-	-	PUNCT
admet-3091	396	8	mater	mater	NOUN
admet-3091	396	9	.	.	PUNCT
admet-3091	397	1	sci	sci	PROPN
admet-3091	397	2	.	.	PUNCT
admet-3091	398	1	ed	ed	NOUN
admet-3091	398	2	.	.	PROPN
admet-3091	399	1	22	22	NUM
admet-3091	399	2	(	(	PUNCT
admet-3091	399	3	2007	2007	NUM
admet-3091	399	4	)	)	PUNCT
admet-3091	399	5	112	112	NUM
admet-3091	399	6	-	-	SYM
admet-3091	399	7	116	116	NUM
admet-3091	399	8	.	.	PUNCT
admet-3091	400	1	https://doi.org/10.1007/s11595005-1112-4	https://doi.org/10.1007/s11595005-1112-4	PROPN
admet-3091	400	2	[	[	X
admet-3091	400	3	39	39	NUM
admet-3091	400	4	]	]	X
admet-3091	400	5	a.p.d	a.p.d	PROPN
admet-3091	400	6	.	.	PROPN
admet-3091	400	7	santos	santos	PROPN
admet-3091	400	8	,	,	PUNCT
admet-3091	400	9	r.c.r.d	r.c.r.d	PROPN
admet-3091	400	10	oliveira	oliveira	PROPN
admet-3091	400	11	,	,	PUNCT
admet-3091	400	12	b.o	b.o	PROPN
admet-3091	400	13	.	.	PROPN
admet-3091	400	14	louchard	louchard	PROPN
admet-3091	400	15	,	,	PUNCT
admet-3091	401	1	a.f.j	a.f.j	NOUN
admet-3091	401	2	.	.	PUNCT
admet-3091	401	3	uchoa	uchoa	NOUN
admet-3091	401	4	,	,	PUNCT
admet-3091	401	5	n.m.p.s	n.m.p.s	PROPN
admet-3091	401	6	ricardo	ricardo	PROPN
admet-3091	401	7	,	,	PUNCT
admet-3091	401	8	l.k.a.m	l.k.a.m	PROPN
admet-3091	401	9	.	.	PROPN
admet-3091	401	10	leal	leal	PROPN
admet-3091	401	11	,	,	PUNCT
admet-3091	401	12	g.	g.	PROPN
admet-3091	401	13	rádisbaptista	rádisbaptista	PROPN
admet-3091	401	14	,	,	PUNCT
admet-3091	401	15	t.g.d	t.g.d	NOUN
admet-3091	401	16	.	.	PUNCT
admet-3091	401	17	araújo	araújo	PROPN
admet-3091	401	18	.	.	PUNCT
admet-3091	402	1	preparation	preparation	NOUN
admet-3091	402	2	of	of	ADP
admet-3091	402	3	plga	plga	NOUN
admet-3091	402	4	nanoparticles	nanoparticle	NOUN
admet-3091	402	5	loaded	load	VERB
admet-3091	402	6	with	with	ADP
admet-3091	402	7	the	the	DET
admet-3091	402	8	anti	anti	ADJ
admet-3091	402	9	-	-	ADJ
admet-3091	402	10	infective	infective	ADJ
admet-3091	402	11	ctn	ctn	NOUN
admet-3091	402	12	[	[	X
admet-3091	402	13	15	15	NUM
admet-3091	402	14	-	-	SYM
admet-3091	402	15	34	34	NUM
admet-3091	402	16	]	]	PUNCT
admet-3091	402	17	peptide	peptide	NOUN
admet-3091	402	18	for	for	ADP
admet-3091	402	19	antifungal	antifungal	ADJ
admet-3091	402	20	application	application	NOUN
admet-3091	402	21	.	.	PUNCT
admet-3091	403	1	brazilian	brazilian	ADJ
admet-3091	403	2	archives	archive	NOUN
admet-3091	403	3	of	of	ADP
admet-3091	403	4	biology	biology	NOUN
admet-3091	403	5	and	and	CCONJ
admet-3091	403	6	technology	technology	NOUN
admet-3091	403	7	66	66	NUM
admet-3091	403	8	(	(	PUNCT
admet-3091	403	9	2023	2023	NUM
admet-3091	403	10	)	)	PUNCT
admet-3091	403	11	20220775	20220775	NUM
admet-3091	403	12	.	.	PUNCT
admet-3091	404	1	https://doi.org/10.1590/1678-4324-2023220775	https://doi.org/10.1590/1678-4324-2023220775	VERB
admet-3091	405	1	[	[	X
admet-3091	405	2	40	40	NUM
admet-3091	405	3	]	]	X
admet-3091	405	4	e.a	e.a	PROPN
admet-3091	405	5	.	.	PROPN
admet-3091	405	6	gosselin	gosselin	PROPN
admet-3091	405	7	,	,	PUNCT
admet-3091	405	8	m.	m.	NOUN
admet-3091	405	9	noshin	noshin	PROPN
admet-3091	405	10	,	,	PUNCT
admet-3091	406	1	s.k	s.k	PROPN
admet-3091	406	2	.	.	PROPN
admet-3091	406	3	black	black	PROPN
admet-3091	406	4	,	,	PUNCT
admet-3091	406	5	c.m	c.m	PROPN
admet-3091	406	6	.	.	PROPN
admet-3091	406	7	jewell	jewell	PROPN
admet-3091	406	8	.	.	PUNCT
admet-3091	406	9	impact	impact	NOUN
admet-3091	406	10	of	of	ADP
admet-3091	406	11	excipients	excipient	NOUN
admet-3091	406	12	on	on	ADP
admet-3091	406	13	stability	stability	NOUN
admet-3091	406	14	of	of	ADP
admet-3091	406	15	polymer	polymer	NOUN
admet-3091	406	16	microparticles	microparticle	NOUN
admet-3091	406	17	for	for	ADP
admet-3091	406	18	autoimmune	autoimmune	ADJ
admet-3091	406	19	therapy	therapy	NOUN
admet-3091	406	20	.	.	PUNCT
admet-3091	407	1	frontiers	frontier	NOUN
admet-3091	407	2	in	in	ADP
admet-3091	407	3	bioengineering	bioengineering	NOUN
admet-3091	407	4	and	and	CCONJ
admet-3091	407	5	biotechnology	biotechnology	NOUN
admet-3091	407	6	8	8	NUM
admet-3091	407	7	(	(	PUNCT
admet-3091	407	8	2021	2021	NUM
admet-3091	407	9	)	)	PUNCT
admet-3091	407	10	609577	609577	NUM
admet-3091	407	11	.	.	PUNCT
admet-3091	408	1	https://doi.org/10.3389/fbioe.2020.609577	https://doi.org/10.3389/fbioe.2020.609577	PROPN
admet-3091	409	1	[	[	X
admet-3091	409	2	41	41	NUM
admet-3091	409	3	]	]	X
admet-3091	409	4	d.	d.	PROPN
admet-3091	409	5	rahmani	rahmani	PROPN
admet-3091	409	6	,	,	PUNCT
admet-3091	409	7	r.a	r.a	PROPN
admet-3091	409	8	.	.	PROPN
admet-3091	409	9	taheri	taheri	PROPN
admet-3091	409	10	,	,	PUNCT
admet-3091	409	11	m.	m.	NOUN
admet-3091	409	12	moosazadeh	moosazadeh	NOUN
admet-3091	409	13	moghaddam	moghaddam	NOUN
admet-3091	409	14	.	.	PUNCT
admet-3091	410	1	targeted	target	VERB
admet-3091	410	2	delivery	delivery	NOUN
admet-3091	410	3	of	of	ADP
admet-3091	410	4	curcumin	curcumin	NOUN
admet-3091	410	5	and	and	CCONJ
admet-3091	410	6	cm11	cm11	PROPN
admet-3091	410	7	peptide	peptide	NOUN
admet-3091	410	8	against	against	ADP
admet-3091	410	9	hepatocellular	hepatocellular	ADJ
admet-3091	410	10	carcinoma	carcinoma	NOUN
admet-3091	410	11	cells	cell	NOUN
admet-3091	410	12	based	base	VERB
admet-3091	410	13	on	on	ADP
admet-3091	410	14	binding	bind	VERB
admet-3091	410	15	affinity	affinity	NOUN
admet-3091	410	16	of	of	ADP
admet-3091	410	17	pres1	pres1	NOUN
admet-3091	410	18	-	-	PUNCT
admet-3091	410	19	coated	coat	VERB
admet-3091	410	20	chitosan	chitosan	NOUN
admet-3091	410	21	nanoparticles	nanoparticle	NOUN
admet-3091	410	22	to	to	ADP
admet-3091	410	23	sb3	sb3	PROPN
admet-3091	410	24	protein	protein	NOUN
admet-3091	410	25	.	.	PUNCT
admet-3091	411	1	amino	amino	ADJ
admet-3091	411	2	acids	acid	NOUN
admet-3091	411	3	57	57	NUM
admet-3091	411	4	(	(	PUNCT
admet-3091	411	5	2025	2025	NUM
admet-3091	411	6	)	)	PUNCT
admet-3091	411	7	12	12	NUM
admet-3091	411	8	.	.	PUNCT
admet-3091	412	1	https://doi.org/10.1007/s00726-024-03438-x	https://doi.org/10.1007/s00726-024-03438-x	PROPN
admet-3091	413	1	[	[	X
admet-3091	413	2	42	42	NUM
admet-3091	413	3	]	]	PUNCT
admet-3091	413	4	f.	f.	PROPN
admet-3091	413	5	bayat	bayat	PROPN
admet-3091	413	6	,	,	PUNCT
admet-3091	413	7	m.	m.	NOUN
admet-3091	413	8	pourmadadi	pourmadadi	PROPN
admet-3091	413	9	,	,	PUNCT
admet-3091	413	10	m.m	m.m	PROPN
admet-3091	413	11	.	.	PROPN
admet-3091	413	12	eshaghi	eshaghi	PROPN
admet-3091	413	13	,	,	PUNCT
admet-3091	413	14	f.	f.	PROPN
admet-3091	413	15	yazdian	yazdian	PROPN
admet-3091	413	16	,	,	PUNCT
admet-3091	413	17	h.	h.	PROPN
admet-3091	413	18	rashedi	rashedi	PROPN
admet-3091	413	19	.	.	PUNCT
admet-3091	414	1	improving	improve	VERB
admet-3091	414	2	release	release	NOUN
admet-3091	414	3	profile	profile	NOUN
admet-3091	414	4	and	and	CCONJ
admet-3091	414	5	anticancer	anticancer	NOUN
admet-3091	414	6	activity	activity	NOUN
admet-3091	414	7	of	of	ADP
admet-3091	414	8	5	5	NUM
admet-3091	414	9	-	-	PUNCT
admet-3091	414	10	fluorouracil	fluorouracil	NOUN
admet-3091	414	11	for	for	ADP
admet-3091	414	12	breast	breast	NOUN
admet-3091	414	13	cancer	cancer	NOUN
admet-3091	414	14	therapy	therapy	NOUN
admet-3091	414	15	using	use	VERB
admet-3091	414	16	a	a	DET
admet-3091	414	17	double	double	ADJ
admet-3091	414	18	drug	drug	NOUN
admet-3091	414	19	delivery	delivery	NOUN
admet-3091	414	20	system	system	NOUN
admet-3091	414	21	:	:	PUNCT
admet-3091	414	22	chitosan	chitosan	NOUN
admet-3091	414	23	/	/	SYM
admet-3091	414	24	agarose	agarose	NOUN
admet-3091	414	25	/	/	SYM
admet-3091	414	26	γ	γ	NOUN
admet-3091	414	27	-	-	PUNCT
admet-3091	414	28	alumina	alumina	NOUN
admet-3091	414	29	nanocomposite@	nanocomposite@	ADV
admet-3091	414	30	double	double	ADJ
admet-3091	414	31	emulsion	emulsion	NOUN
admet-3091	414	32	.	.	PUNCT
admet-3091	415	1	journal	journal	PROPN
admet-3091	415	2	of	of	ADP
admet-3091	415	3	cluster	cluster	NOUN
admet-3091	415	4	science	science	NOUN
admet-3091	415	5	34	34	NUM
admet-3091	415	6	(	(	PUNCT
admet-3091	415	7	2023	2023	NUM
admet-3091	415	8	)	)	PUNCT
admet-3091	415	9	2565	2565	NUM
admet-3091	415	10	-	-	SYM
admet-3091	415	11	2577	2577	NUM
admet-3091	415	12	.	.	PUNCT
admet-3091	416	1	https://doi.org/10.1007/s10876-023-02405-y	https://doi.org/10.1007/s10876-023-02405-y	PROPN
admet-3091	416	2	[	[	X
admet-3091	416	3	43	43	NUM
admet-3091	416	4	]	]	PUNCT
admet-3091	416	5	b.	b.	PROPN
admet-3091	416	6	devrim	devrim	PROPN
admet-3091	416	7	,	,	PUNCT
admet-3091	416	8	a.	a.	NOUN
admet-3091	416	9	bozkır	bozkır	PROPN
admet-3091	416	10	.	.	PUNCT
admet-3091	417	1	preparation	preparation	NOUN
admet-3091	417	2	and	and	CCONJ
admet-3091	417	3	in	in	ADP
admet-3091	417	4	vitro	vitro	X
admet-3091	417	5	evaluation	evaluation	NOUN
admet-3091	417	6	of	of	ADP
admet-3091	417	7	surface	surface	NOUN
admet-3091	417	8	-	-	PUNCT
admet-3091	417	9	modified	modify	VERB
admet-3091	417	10	poly	poly	ADJ
admet-3091	417	11	(	(	PUNCT
admet-3091	417	12	lactide	lactide	ADV
admet-3091	417	13	-	-	PUNCT
admet-3091	417	14	coglycolide	coglycolide	NOUN
admet-3091	417	15	)	)	PUNCT
admet-3091	417	16	microparticles	microparticle	NOUN
admet-3091	417	17	as	as	ADP
admet-3091	417	18	biodegradable	biodegradable	ADJ
admet-3091	417	19	drug	drug	NOUN
admet-3091	417	20	carriers	carrier	NOUN
admet-3091	417	21	for	for	ADP
admet-3091	417	22	pulmonary	pulmonary	ADJ
admet-3091	417	23	peptide	peptide	NOUN
admet-3091	417	24	and	and	CCONJ
admet-3091	417	25	protein	protein	NOUN
admet-3091	417	26	delivery	delivery	NOUN
admet-3091	417	27	.	.	PUNCT
admet-3091	418	1	journal	journal	NOUN
admet-3091	418	2	of	of	ADP
admet-3091	418	3	microencapsulation	microencapsulation	NOUN
admet-3091	418	4	31	31	NUM
admet-3091	418	5	(	(	PUNCT
admet-3091	418	6	2014	2014	NUM
admet-3091	418	7	)	)	PUNCT
admet-3091	418	8	355	355	NUM
admet-3091	418	9	-	-	SYM
admet-3091	418	10	362	362	NUM
admet-3091	418	11	.	.	PUNCT
admet-3091	418	12	https://doi.org/10.3109/02652048.2013.858791	https://doi.org/10.3109/02652048.2013.858791	PUNCT
admet-3091	419	1	[	[	X
admet-3091	419	2	44	44	NUM
admet-3091	419	3	]	]	SYM
admet-3091	419	4	h.k	h.k	PROPN
admet-3091	419	5	.	.	PROPN
admet-3091	419	6	büyükbayraktar	büyükbayraktar	PROPN
admet-3091	419	7	,	,	PUNCT
admet-3091	419	8	p.p	p.p	PROPN
admet-3091	419	9	.	.	PROPN
admet-3091	419	10	arayıcı	arayıcı	PROPN
admet-3091	419	11	,	,	PUNCT
admet-3091	419	12	m.	m.	NOUN
admet-3091	419	13	ihlamur	ihlamur	PROPN
admet-3091	419	14	,	,	PUNCT
admet-3091	419	15	d.	d.	PROPN
admet-3091	419	16	gökkaya	gökkaya	PROPN
admet-3091	419	17	,	,	PUNCT
admet-3091	419	18	m.	m.	PROPN
admet-3091	419	19	karahan	karahan	PROPN
admet-3091	419	20	,	,	PUNCT
admet-3091	419	21	e.s	e.s	PROPN
admet-3091	419	22	.	.	PROPN
admet-3091	419	23	abamor	abamor	PROPN
admet-3091	419	24	,	,	PUNCT
admet-3091	419	25	m.	m.	NOUN
admet-3091	419	26	topuzoğulları	topuzoğulları	PROPN
admet-3091	419	27	.	.	PUNCT
admet-3091	420	1	effect	effect	NOUN
admet-3091	420	2	of	of	ADP
admet-3091	420	3	polycation	polycation	NOUN
admet-3091	420	4	coating	coat	VERB
admet-3091	420	5	on	on	ADP
admet-3091	420	6	the	the	DET
admet-3091	420	7	long	long	ADJ
admet-3091	420	8	-	-	PUNCT
admet-3091	420	9	term	term	NOUN
admet-3091	420	10	pulsatile	pulsatile	NOUN
admet-3091	420	11	release	release	NOUN
admet-3091	420	12	of	of	ADP
admet-3091	420	13	antigenic	antigenic	ADJ
admet-3091	420	14	esat-61–20	esat-61–20	NOUN
admet-3091	420	15	peptide	peptide	NOUN
admet-3091	420	16	from	from	ADP
admet-3091	420	17	plga	plga	NOUN
admet-3091	420	18	nanoparticles	nanoparticle	NOUN
admet-3091	420	19	.	.	PUNCT
admet-3091	421	1	colloids	colloid	NOUN
admet-3091	421	2	and	and	CCONJ
admet-3091	421	3	surfaces	surface	NOUN
admet-3091	421	4	b	b	PROPN
admet-3091	421	5	228	228	NUM
admet-3091	421	6	(	(	PUNCT
admet-3091	421	7	2023	2023	NUM
admet-3091	421	8	)	)	PUNCT
admet-3091	421	9	113421	113421	NUM
admet-3091	421	10	.	.	PUNCT
admet-3091	422	1	https://doi.org/10.1016/j.colsurfb.2023.113421	https://doi.org/10.1016/j.colsurfb.2023.113421	NOUN
admet-3091	422	2	[	[	X
admet-3091	422	3	45	45	NUM
admet-3091	422	4	]	]	PUNCT
admet-3091	422	5	k.	k.	NOUN
admet-3091	422	6	michaelides	michaelides	PROPN
admet-3091	422	7	,	,	PUNCT
admet-3091	422	8	m.a	m.a	PROPN
admet-3091	422	9	.	.	PROPN
admet-3091	422	10	al	al	PROPN
admet-3091	422	11	tahan	tahan	PROPN
admet-3091	422	12	,	,	PUNCT
admet-3091	422	13	y.	y.	PROPN
admet-3091	422	14	zhou	zhou	PROPN
admet-3091	422	15	,	,	PUNCT
admet-3091	422	16	g.f	g.f	PROPN
admet-3091	422	17	.	.	PROPN
admet-3091	422	18	trindade	trindade	PROPN
admet-3091	422	19	,	,	PUNCT
admet-3091	422	20	d.j	d.j	PROPN
admet-3091	422	21	.	.	PROPN
admet-3091	422	22	ca	can	AUX
admet-3091	422	23	nt	not	PART
admet-3091	422	24	,	,	PUNCT
admet-3091	422	25	y.	y.	PROPN
admet-3091	422	26	pei	pei	PROPN
admet-3091	422	27	,	,	PUNCT
admet-3091	422	28	p.	p.	PROPN
admet-3091	422	29	dulal	dulal	PROPN
admet-3091	422	30	,	,	PUNCT
admet-3091	422	31	a.	a.	PROPN
admet-3091	422	32	al	al	PROPN
admet-3091	422	33	-	-	PUNCT
admet-3091	422	34	khattawi	khattawi	PROPN
admet-3091	422	35	.	.	PUNCT
admet-3091	423	1	new	new	ADJ
admet-3091	423	2	insights	insight	NOUN
admet-3091	423	3	on	on	ADP
admet-3091	423	4	the	the	DET
admet-3091	423	5	burst	burst	ADJ
admet-3091	423	6	release	release	NOUN
admet-3091	423	7	kinetics	kinetic	NOUN
admet-3091	423	8	of	of	ADP
admet-3091	423	9	spray	spray	NOUN
admet-3091	423	10	-	-	PUNCT
admet-3091	423	11	dried	dry	VERB
admet-3091	423	12	plga	plga	NOUN
admet-3091	423	13	microspheres	microsphere	NOUN
admet-3091	423	14	.	.	PUNCT
admet-3091	424	1	molecular	molecular	ADJ
admet-3091	424	2	pharmaceutics	pharmaceutic	NOUN
admet-3091	424	3	21	21	NUM
admet-3091	424	4	(	(	PUNCT
admet-3091	424	5	2024	2024	NUM
admet-3091	424	6	)	)	PUNCT
admet-3091	424	7	6245	6245	NUM
admet-3091	424	8	-	-	SYM
admet-3091	424	9	6256	6256	NUM
admet-3091	424	10	.	.	PUNCT
admet-3091	425	1	https://doi.org/10.1021/acs.molpharmaceut.4c00686	https://doi.org/10.1021/acs.molpharmaceut.4c00686	DET
admet-3091	425	2	[	[	X
admet-3091	425	3	46	46	NUM
admet-3091	425	4	]	]	X
admet-3091	425	5	c.	c.	PROPN
admet-3091	425	6	busatto	busatto	PROPN
admet-3091	425	7	,	,	PUNCT
admet-3091	425	8	j.	j.	PROPN
admet-3091	425	9	pesoa	pesoa	PROPN
admet-3091	425	10	,	,	PUNCT
admet-3091	425	11	i.	i.	PROPN
admet-3091	425	12	helbling	helbling	PROPN
admet-3091	425	13	,	,	PUNCT
admet-3091	425	14	j.	j.	PROPN
admet-3091	425	15	luna	luna	PROPN
admet-3091	425	16	,	,	PUNCT
admet-3091	425	17	d.	d.	PROPN
admet-3091	425	18	estenoz	estenoz	PROPN
admet-3091	425	19	.	.	PUNCT
admet-3091	426	1	effect	effect	NOUN
admet-3091	426	2	of	of	ADP
admet-3091	426	3	particle	particle	NOUN
admet-3091	426	4	size	size	NOUN
admet-3091	426	5	,	,	PUNCT
admet-3091	426	6	polydispersity	polydispersity	NOUN
admet-3091	426	7	and	and	CCONJ
admet-3091	426	8	polymer	polymer	NOUN
admet-3091	426	9	degradation	degradation	NOUN
admet-3091	426	10	on	on	ADP
admet-3091	426	11	progesterone	progesterone	NOUN
admet-3091	426	12	release	release	NOUN
admet-3091	426	13	from	from	ADP
admet-3091	426	14	plga	plga	NOUN
admet-3091	426	15	microparticles	microparticle	NOUN
admet-3091	426	16	:	:	PUNCT
admet-3091	426	17	experimental	experimental	ADJ
admet-3091	426	18	and	and	CCONJ
admet-3091	426	19	mathematical	mathematical	ADJ
admet-3091	426	20	modeling	modeling	NOUN
admet-3091	426	21	.	.	PUNCT
admet-3091	427	1	international	international	ADJ
admet-3091	427	2	journal	journal	PROPN
admet-3091	427	3	of	of	ADP
admet-3091	427	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	427	5	536	536	NUM
admet-3091	427	6	(	(	PUNCT
admet-3091	427	7	2018	2018	NUM
admet-3091	427	8	)	)	PUNCT
admet-3091	427	9	360	360	NUM
admet-3091	427	10	-	-	SYM
admet-3091	427	11	369	369	NUM
admet-3091	427	12	.	.	PUNCT
admet-3091	428	1	https://doi.org/10.1016/j.ijpharm.2017.12.006	https://doi.org/10.1016/j.ijpharm.2017.12.006	NOUN
admet-3091	428	2	[	[	X
admet-3091	428	3	47	47	NUM
admet-3091	428	4	]	]	PUNCT
admet-3091	428	5	f.	f.	PROPN
admet-3091	428	6	khademi	khademi	PROPN
admet-3091	428	7	,	,	PUNCT
admet-3091	428	8	a.	a.	PROPN
admet-3091	428	9	sahebkar	sahebkar	PROPN
admet-3091	428	10	,	,	PUNCT
admet-3091	428	11	m.	m.	NOUN
admet-3091	428	12	fasihi‐ramandi	fasihi‐ramandi	PROPN
admet-3091	428	13	,	,	PUNCT
admet-3091	428	14	r.a	r.a	PROPN
admet-3091	428	15	.	.	PROPN
admet-3091	428	16	taheri	taheri	PROPN
admet-3091	428	17	.	.	PUNCT
admet-3091	429	1	induction	induction	NOUN
admet-3091	429	2	of	of	ADP
admet-3091	429	3	strong	strong	ADJ
admet-3091	429	4	immune	immune	ADJ
admet-3091	429	5	response	response	NOUN
admet-3091	429	6	against	against	ADP
admet-3091	429	7	a	a	DET
admet-3091	429	8	multicomponent	multicomponent	ADJ
admet-3091	429	9	antigen	antigen	NOUN
admet-3091	429	10	of	of	ADP
admet-3091	429	11	mycobacterium	mycobacterium	NOUN
admet-3091	429	12	tuberculosis	tuberculosis	NOUN
admet-3091	429	13	in	in	ADP
admet-3091	429	14	balb	balb	ADJ
admet-3091	429	15	/	/	SYM
admet-3091	429	16	c	c	NOUN
admet-3091	429	17	mice	mouse	NOUN
admet-3091	429	18	using	use	VERB
admet-3091	429	19	plga	plga	NOUN
admet-3091	429	20	and	and	CCONJ
admet-3091	429	21	dotap	dotap	ADJ
admet-3091	429	22	adjuvant	adjuvant	NOUN
admet-3091	429	23	.	.	PUNCT
admet-3091	430	1	apmis	apmis	PROPN
admet-3091	430	2	126	126	NUM
admet-3091	430	3	(	(	PUNCT
admet-3091	430	4	2018	2018	NUM
admet-3091	430	5	)	)	PUNCT
admet-3091	430	6	509	509	NUM
admet-3091	430	7	-	-	SYM
admet-3091	430	8	514	514	NUM
admet-3091	430	9	.	.	PUNCT
admet-3091	431	1	https://doi.org/10.1111/apm.12851	https://doi.org/10.1111/apm.12851	PROPN
admet-3091	431	2	[	[	X
admet-3091	431	3	48	48	NUM
admet-3091	431	4	]	]	PUNCT
admet-3091	431	5	f.	f.	PROPN
admet-3091	431	6	wan	wan	PROPN
admet-3091	431	7	,	,	PUNCT
admet-3091	431	8	m.	m.	PROPN
admet-3091	431	9	yang	yang	PROPN
admet-3091	431	10	.	.	PROPN
admet-3091	431	11	2016	2016	NUM
admet-3091	431	12	.	.	PUNCT
admet-3091	432	1	design	design	NOUN
admet-3091	432	2	of	of	ADP
admet-3091	432	3	plga	plga	NOUN
admet-3091	432	4	-	-	PUNCT
admet-3091	432	5	based	base	VERB
admet-3091	432	6	depot	depot	NOUN
admet-3091	432	7	delivery	delivery	NOUN
admet-3091	432	8	systems	system	NOUN
admet-3091	432	9	for	for	ADP
admet-3091	432	10	biopharmaceuticals	biopharmaceutical	NOUN
admet-3091	432	11	prepared	prepare	VERB
admet-3091	432	12	by	by	ADP
admet-3091	432	13	spray	spray	NOUN
admet-3091	432	14	drying	dry	VERB
admet-3091	432	15	.	.	PUNCT
admet-3091	433	1	international	international	ADJ
admet-3091	433	2	journal	journal	PROPN
admet-3091	433	3	of	of	ADP
admet-3091	433	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	433	5	498	498	NUM
admet-3091	433	6	(	(	PUNCT
admet-3091	433	7	2016	2016	NUM
admet-3091	433	8	)	)	PUNCT
admet-3091	433	9	82	82	NUM
admet-3091	433	10	-	-	SYM
admet-3091	433	11	95	95	NUM
admet-3091	433	12	.	.	PUNCT
admet-3091	434	1	https://doi.org/10.1016/j.ijpharm.2015.12.025	https://doi.org/10.1016/j.ijpharm.2015.12.025	NOUN
admet-3091	434	2	[	[	X
admet-3091	434	3	49	49	NUM
admet-3091	434	4	]	]	PUNCT
admet-3091	434	5	s.	s.	PROPN
admet-3091	434	6	marquina	marquina	PROPN
admet-3091	434	7	,	,	PUNCT
admet-3091	434	8	m.	m.	NOUN
admet-3091	434	9	ozgul	ozgul	PROPN
admet-3091	434	10	,	,	PUNCT
admet-3091	434	11	k.	k.	PROPN
admet-3091	434	12	robertson	robertson	PROPN
admet-3091	434	13	-	-	PUNCT
admet-3091	434	14	brown	brown	PROPN
admet-3091	434	15	,	,	PUNCT
admet-3091	434	16	m.c	m.c	PROPN
admet-3091	434	17	.	.	PROPN
admet-3091	434	18	kenney	kenney	PROPN
admet-3091	434	19	.	.	PUNCT
admet-3091	435	1	a	a	DET
admet-3091	435	2	review	review	NOUN
admet-3091	435	3	on	on	ADP
admet-3091	435	4	plga	plga	NOUN
admet-3091	435	5	particles	particle	NOUN
admet-3091	435	6	as	as	ADP
admet-3091	435	7	a	a	DET
admet-3091	435	8	sustained	sustained	ADJ
admet-3091	435	9	drug	drug	NOUN
admet-3091	435	10	-	-	PUNCT
admet-3091	435	11	delivery	delivery	NOUN
admet-3091	435	12	system	system	NOUN
admet-3091	435	13	and	and	CCONJ
admet-3091	435	14	its	its	PRON
admet-3091	435	15	effect	effect	NOUN
admet-3091	435	16	on	on	ADP
admet-3091	435	17	the	the	DET
admet-3091	435	18	retina	retina	NOUN
admet-3091	435	19	.	.	PUNCT
admet-3091	436	1	experimental	experimental	ADJ
admet-3091	436	2	eye	eye	PROPN
admet-3091	436	3	research	research	NOUN
admet-3091	436	4	235	235	NUM
admet-3091	436	5	(	(	PUNCT
admet-3091	436	6	2023	2023	NUM
admet-3091	436	7	)	)	PUNCT
admet-3091	436	8	109626	109626	NUM
admet-3091	436	9	.	.	PUNCT
admet-3091	437	1	https://doi.org/10.1016/j.exer.2023.109626	https://doi.org/10.1016/j.exer.2023.109626	NOUN
admet-3091	438	1	[	[	X
admet-3091	438	2	50	50	NUM
admet-3091	438	3	]	]	PUNCT
admet-3091	438	4	p.	p.	PROPN
admet-3091	438	5	girotra	girotra	PROPN
admet-3091	438	6	,	,	PUNCT
admet-3091	438	7	s.k	s.k	PROPN
admet-3091	438	8	.	.	PROPN
admet-3091	438	9	singh	singh	PROPN
admet-3091	438	10	,	,	PUNCT
admet-3091	438	11	k.	k.	PROPN
admet-3091	438	12	nagpal	nagpal	PROPN
admet-3091	438	13	.	.	PUNCT
admet-3091	439	1	supercritical	supercritical	ADJ
admet-3091	439	2	fluid	fluid	ADJ
admet-3091	439	3	technology	technology	NOUN
admet-3091	439	4	:	:	PUNCT
admet-3091	439	5	a	a	DET
admet-3091	439	6	promising	promising	ADJ
admet-3091	439	7	approach	approach	NOUN
admet-3091	439	8	in	in	ADP
admet-3091	439	9	pharmaceutical	pharmaceutical	ADJ
admet-3091	439	10	research	research	NOUN
admet-3091	439	11	.	.	PUNCT
admet-3091	440	1	pharmaceutical	pharmaceutical	NOUN
admet-3091	440	2	development	development	NOUN
admet-3091	440	3	and	and	CCONJ
admet-3091	440	4	technology	technology	NOUN
admet-3091	440	5	18	18	NUM
admet-3091	440	6	(	(	PUNCT
admet-3091	440	7	2013	2013	NUM
admet-3091	440	8	)	)	PUNCT
admet-3091	440	9	22	22	NUM
admet-3091	440	10	-	-	SYM
admet-3091	440	11	38	38	NUM
admet-3091	440	12	.	.	PUNCT
admet-3091	440	13	https://doi.org/10.3109/10837450.2012.726998	https://doi.org/10.3109/10837450.2012.726998	PUNCT
admet-3091	441	1	[	[	X
admet-3091	441	2	51	51	NUM
admet-3091	441	3	]	]	PUNCT
admet-3091	441	4	t.	t.	PROPN
admet-3091	441	5	ren	ren	PROPN
admet-3091	441	6	,	,	PUNCT
admet-3091	441	7	x.	x.	PROPN
admet-3091	441	8	zheng	zheng	PROPN
admet-3091	441	9	,	,	PUNCT
admet-3091	441	10	r.	r.	PROPN
admet-3091	441	11	bai	bai	PROPN
admet-3091	441	12	,	,	PUNCT
admet-3091	441	13	y.	y.	PROPN
admet-3091	441	14	yang	yang	PROPN
admet-3091	441	15	,	,	PUNCT
admet-3091	441	16	l.	l.	PROPN
admet-3091	441	17	jian	jian	PROPN
admet-3091	441	18	.	.	PUNCT
admet-3091	442	1	utilization	utilization	NOUN
admet-3091	442	2	of	of	ADP
admet-3091	442	3	plga	plga	NOUN
admet-3091	442	4	nanoparticles	nanoparticle	NOUN
admet-3091	442	5	in	in	ADP
admet-3091	442	6	yeast	yeast	NOUN
admet-3091	442	7	cell	cell	NOUN
admet-3091	442	8	wall	wall	NOUN
admet-3091	442	9	particle	particle	NOUN
admet-3091	442	10	system	system	NOUN
admet-3091	442	11	for	for	ADP
admet-3091	442	12	oral	oral	ADJ
admet-3091	442	13	targeted	target	VERB
admet-3091	442	14	delivery	delivery	NOUN
admet-3091	442	15	of	of	ADP
admet-3091	442	16	exenatide	exenatide	NOUN
admet-3091	442	17	to	to	PART
admet-3091	442	18	improve	improve	VERB
admet-3091	442	19	its	its	PRON
admet-3091	442	20	hypoglycemic	hypoglycemic	ADJ
admet-3091	442	21	efficacy	efficacy	NOUN
admet-3091	442	22	.	.	PUNCT
admet-3091	443	1	international	international	ADJ
admet-3091	443	2	journal	journal	PROPN
admet-3091	443	3	of	of	ADP
admet-3091	443	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	443	5	601	601	NUM
admet-3091	443	6	(	(	PUNCT
admet-3091	443	7	2021	2021	NUM
admet-3091	443	8	)	)	PUNCT
admet-3091	443	9	120583	120583	NUM
admet-3091	443	10	.	.	PUNCT
admet-3091	444	1	https://doi.org/10.1016/j.ijpharm.2021.120583	https://doi.org/10.1016/j.ijpharm.2021.120583	NOUN
admet-3091	445	1	[	[	X
admet-3091	445	2	52	52	NUM
admet-3091	445	3	]	]	PUNCT
admet-3091	445	4	j.	j.	PROPN
admet-3091	445	5	yuan	yuan	PROPN
admet-3091	445	6	,	,	PUNCT
admet-3091	445	7	m.	m.	NOUN
admet-3091	445	8	guo	guo	PROPN
admet-3091	445	9	,	,	PUNCT
admet-3091	445	10	s.	s.	PROPN
admet-3091	445	11	zhao	zhao	PROPN
admet-3091	445	12	,	,	PUNCT
admet-3091	445	13	j.	j.	PROPN
admet-3091	445	14	li	li	PROPN
admet-3091	445	15	,	,	PUNCT
admet-3091	445	16	x.	x.	PROPN
admet-3091	445	17	wang	wang	PROPN
admet-3091	445	18	,	,	PUNCT
admet-3091	445	19	j.	j.	PROPN
admet-3091	445	20	yang	yang	PROPN
admet-3091	445	21	,	,	PUNCT
admet-3091	445	22	z.	z.	PROPN
admet-3091	445	23	jin	jin	PROPN
admet-3091	445	24	x.	x.	PROPN
admet-3091	445	25	song	song	PROPN
admet-3091	445	26	.	.	PUNCT
admet-3091	446	1	core	core	NOUN
admet-3091	446	2	-	-	PUNCT
admet-3091	446	3	shell	shell	NOUN
admet-3091	446	4	lipid	lipid	NOUN
admet-3091	446	5	-	-	PUNCT
admet-3091	446	6	polymeric	polymeric	ADJ
admet-3091	446	7	nanoparticles	nanoparticle	NOUN
admet-3091	446	8	for	for	ADP
admet-3091	446	9	enhanced	enhanced	ADJ
admet-3091	446	10	oral	oral	ADJ
admet-3091	446	11	bioavailability	bioavailability	NOUN
admet-3091	446	12	and	and	CCONJ
admet-3091	446	13	antihypertensive	antihypertensive	ADJ
admet-3091	446	14	efficacy	efficacy	NOUN
admet-3091	446	15	of	of	ADP
admet-3091	446	16	ky5	ky5	PROPN
admet-3091	446	17	peptide	peptide	NOUN
admet-3091	446	18	.	.	PUNCT
admet-3091	447	1	chinese	chinese	ADJ
admet-3091	447	2	chemical	chemical	PROPN
admet-3091	447	3	letters	letter	NOUN
admet-3091	447	4	34	34	NUM
admet-3091	447	5	(	(	PUNCT
admet-3091	447	6	2023	2023	NUM
admet-3091	447	7	)	)	PUNCT
admet-3091	447	8	107943	107943	NUM
admet-3091	447	9	.	.	PUNCT
admet-3091	448	1	https://doi.org/10.1016/j.cclet.2022.107943	https://doi.org/10.1016/j.cclet.2022.107943	NOUN
admet-3091	448	2	https://doi.org/10.1007/s11595-005-1112-4	https://doi.org/10.1007/s11595-005-1112-4	VERB
admet-3091	448	3	https://doi.org/10.1007/s11595-005-1112-4	https://doi.org/10.1007/s11595-005-1112-4	NUM
admet-3091	448	4	https://doi.org/10.1590/1678-4324-2023220775	https://doi.org/10.1590/1678-4324-2023220775	VERB
admet-3091	449	1	https://doi.org/10.3389/fbioe.2020.609577	https://doi.org/10.3389/fbioe.2020.609577	PROPN
admet-3091	449	2	https://doi.org/10.1007/s00726-024-03438-x	https://doi.org/10.1007/s00726-024-03438-x	PROPN
admet-3091	449	3	https://doi.org/10.1007/s10876-023-02405-y	https://doi.org/10.1007/s10876-023-02405-y	PROPN
admet-3091	449	4	https://doi.org/10.3109/02652048.2013.858791	https://doi.org/10.3109/02652048.2013.858791	PROPN
admet-3091	450	1	https://doi.org/10.1016/j.colsurfb.2023.113421	https://doi.org/10.1016/j.colsurfb.2023.113421	VERB
admet-3091	450	2	https://doi.org/10.1021/acs.molpharmaceut.4c00686	https://doi.org/10.1021/acs.molpharmaceut.4c00686	PRON
admet-3091	450	3	https://doi.org/10.1016/j.ijpharm.2017.12.006	https://doi.org/10.1016/j.ijpharm.2017.12.006	ADJ
admet-3091	450	4	https://doi.org/10.1111/apm.12851	https://doi.org/10.1111/apm.12851	NOUN
admet-3091	450	5	https://doi.org/10.1016/j.ijpharm.2015.12.025	https://doi.org/10.1016/j.ijpharm.2015.12.025	VERB
admet-3091	450	6	https://doi.org/10.1016/j.exer.2023.109626	https://doi.org/10.1016/j.exer.2023.109626	PROPN
admet-3091	450	7	https://doi.org/10.3109/10837450.2012.726998	https://doi.org/10.3109/10837450.2012.726998	PROPN
admet-3091	451	1	https://doi.org/10.1016/j.ijpharm.2021.120583	https://doi.org/10.1016/j.ijpharm.2021.120583	PROPN
admet-3091	451	2	https://doi.org/10.1016/j.cclet.2022.107943	https://doi.org/10.1016/j.cclet.2022.107943	PROPN
admet-3091	451	3	admet	admet	PROPN
admet-3091	451	4	&	&	CCONJ
admet-3091	451	5	dmpk	dmpk	PROPN
admet-3091	451	6	00(0	00(0	PROPN
admet-3091	451	7	)	)	PUNCT
admet-3091	451	8	(	(	PUNCT
admet-3091	451	9	2025	2025	NUM
admet-3091	451	10	)	)	PUNCT
admet-3091	451	11	3091	3091	NUM
admet-3091	451	12	plga	plga	NOUN
admet-3091	451	13	nanoparticles	nanoparticle	NOUN
admet-3091	451	14	and	and	CCONJ
admet-3091	451	15	microparticles	microparticle	NOUN
admet-3091	451	16	for	for	ADP
admet-3091	451	17	peptide	peptide	ADJ
admet-3091	451	18	delivery	delivery	NOUN
admet-3091	451	19	doi	doi	NOUN
admet-3091	451	20	:	:	PUNCT
admet-3091	451	21	https://doi.org/10.5599/admet.3091	https://doi.org/10.5599/admet.3091	NOUN
admet-3091	451	22	17	17	NUM
admet-3091	452	1	[	[	X
admet-3091	452	2	53	53	NUM
admet-3091	452	3	]	]	PUNCT
admet-3091	452	4	h.	h.	PROPN
admet-3091	452	5	sun	sun	PROPN
admet-3091	452	6	,	,	PUNCT
admet-3091	452	7	d.	d.	PROPN
admet-3091	452	8	liu	liu	PROPN
admet-3091	452	9	,	,	PUNCT
admet-3091	452	10	y.	y.	PROPN
admet-3091	452	11	li	li	PROPN
admet-3091	452	12	,	,	PUNCT
admet-3091	452	13	x	x	PROPN
admet-3091	452	14	..	..	PUNCT
admet-3091	452	15	tang	tang	PROPN
admet-3091	452	16	,	,	PUNCT
admet-3091	452	17	y.	y.	PROPN
admet-3091	452	18	cong	cong	PROPN
admet-3091	452	19	.	.	PUNCT
admet-3091	453	1	preparation	preparation	NOUN
admet-3091	453	2	and	and	CCONJ
admet-3091	453	3	in	in	ADP
admet-3091	453	4	vitro	vitro	X
admet-3091	453	5	/	/	SYM
admet-3091	453	6	in	in	ADP
admet-3091	453	7	vivo	vivo	ADJ
admet-3091	453	8	characterization	characterization	NOUN
admet-3091	453	9	of	of	ADP
admet-3091	453	10	entericcoated	entericcoate	VERB
admet-3091	453	11	nanoparticles	nanoparticle	NOUN
admet-3091	453	12	loaded	load	VERB
admet-3091	453	13	with	with	ADP
admet-3091	453	14	the	the	DET
admet-3091	453	15	antihypertensive	antihypertensive	ADJ
admet-3091	453	16	peptide	peptide	NOUN
admet-3091	453	17	vlpvpr	vlpvpr	NOUN
admet-3091	453	18	.	.	PUNCT
admet-3091	454	1	international	international	ADJ
admet-3091	454	2	journal	journal	PROPN
admet-3091	454	3	of	of	ADP
admet-3091	454	4	nanomedicine	nanomedicine	NOUN
admet-3091	454	5	9	9	NUM
admet-3091	454	6	(	(	PUNCT
admet-3091	454	7	2014	2014	NUM
admet-3091	454	8	)	)	PUNCT
admet-3091	454	9	1709	1709	NUM
admet-3091	454	10	-	-	SYM
admet-3091	454	11	1716	1716	NUM
admet-3091	454	12	.	.	PUNCT
admet-3091	455	1	https://doi.org/10.2147/ijn.s56092	https://doi.org/10.2147/ijn.s56092	X
admet-3091	456	1	[	[	X
admet-3091	456	2	54	54	NUM
admet-3091	456	3	]	]	X
admet-3091	456	4	y.	y.	PROPN
admet-3091	456	5	wang	wang	PROPN
admet-3091	456	6	,	,	PUNCT
admet-3091	456	7	a.	a.	PROPN
admet-3091	456	8	otte	otte	PROPN
admet-3091	456	9	,	,	PUNCT
admet-3091	456	10	h.	h.	PROPN
admet-3091	456	11	park	park	PROPN
admet-3091	456	12	,	,	PUNCT
admet-3091	456	13	k.	k.	PROPN
admet-3091	456	14	park	park	PROPN
admet-3091	456	15	.	.	PUNCT
admet-3091	457	1	in	in	ADP
admet-3091	457	2	vitro	vitro	NOUN
admet-3091	457	3	-	-	PUNCT
admet-3091	457	4	in	in	ADP
admet-3091	457	5	vivo	vivo	NOUN
admet-3091	457	6	correlation	correlation	NOUN
admet-3091	457	7	(	(	PUNCT
admet-3091	457	8	ivivc	ivivc	PROPN
admet-3091	457	9	)	)	PUNCT
admet-3091	457	10	development	development	NOUN
admet-3091	457	11	for	for	ADP
admet-3091	457	12	long	long	ADV
admet-3091	457	13	-	-	PUNCT
admet-3091	457	14	acting	act	VERB
admet-3091	457	15	injectable	injectable	ADJ
admet-3091	457	16	drug	drug	NOUN
admet-3091	457	17	products	product	NOUN
admet-3091	457	18	based	base	VERB
admet-3091	457	19	on	on	ADP
admet-3091	457	20	poly	poly	ADJ
admet-3091	457	21	(	(	PUNCT
admet-3091	457	22	lactide	lactide	ADV
admet-3091	457	23	-	-	PUNCT
admet-3091	457	24	co	co	NOUN
admet-3091	457	25	-	-	NOUN
admet-3091	457	26	glycolide	glycolide	ADJ
admet-3091	457	27	)	)	PUNCT
admet-3091	457	28	.	.	PUNCT
admet-3091	458	1	journal	journal	PROPN
admet-3091	458	2	of	of	ADP
admet-3091	458	3	controlled	control	VERB
admet-3091	458	4	release	release	NOUN
admet-3091	458	5	377	377	NUM
admet-3091	458	6	(	(	PUNCT
admet-3091	458	7	2025	2025	NUM
admet-3091	458	8	)	)	PUNCT
admet-3091	458	9	186	186	NUM
admet-3091	458	10	-	-	SYM
admet-3091	458	11	196	196	NUM
admet-3091	458	12	.	.	PUNCT
admet-3091	459	1	https://doi.org/10.1016/j.jconrel.2024.11.021	https://doi.org/10.1016/j.jconrel.2024.11.021	NOUN
admet-3091	460	1	[	[	X
admet-3091	460	2	55	55	NUM
admet-3091	460	3	]	]	X
admet-3091	460	4	r.	r.	PROPN
admet-3091	460	5	sharifi	sharifi	PROPN
admet-3091	460	6	,	,	PUNCT
admet-3091	460	7	m.	m.	NOUN
admet-3091	460	8	soloway	soloway	PROPN
admet-3091	460	9	,	,	PUNCT
admet-3091	460	10	r.j	r.j	PROPN
admet-3091	460	11	.	.	PROPN
admet-3091	460	12	correa	correa	PROPN
admet-3091	460	13	jr	jr	PROPN
admet-3091	460	14	,	,	PUNCT
admet-3091	460	15	a.g	a.g	PROPN
admet-3091	460	16	.	.	PROPN
admet-3091	460	17	glass	glass	PROPN
admet-3091	460	18	,	,	PUNCT
admet-3091	460	19	p.d	p.d	PROPN
admet-3091	460	20	.	.	PROPN
admet-3091	460	21	guinan	guinan	PROPN
admet-3091	460	22	,	,	PUNCT
admet-3091	460	23	m.b	m.b	PROPN
admet-3091	460	24	.	.	PROPN
admet-3091	460	25	garnick	garnick	PROPN
admet-3091	460	26	,	,	PUNCT
admet-3091	460	27	l.m	l.m	PROPN
admet-3091	460	28	.	.	PROPN
admet-3091	460	29	glode	glode	PROPN
admet-3091	460	30	,	,	PUNCT
admet-3091	460	31	j.a	j.a	PROPN
admet-3091	460	32	.	.	PROPN
admet-3091	460	33	smith	smith	PROPN
admet-3091	460	34	,	,	PUNCT
admet-3091	460	35	b.s	b.s	PROPN
admet-3091	460	36	.	.	PROPN
admet-3091	460	37	stein	stein	PROPN
admet-3091	460	38	.	.	PUNCT
admet-3091	461	1	clinical	clinical	ADJ
admet-3091	461	2	study	study	NOUN
admet-3091	461	3	of	of	ADP
admet-3091	461	4	leuprolide	leuprolide	NOUN
admet-3091	461	5	depot	depot	NOUN
admet-3091	461	6	formulation	formulation	NOUN
admet-3091	461	7	in	in	ADP
admet-3091	461	8	the	the	DET
admet-3091	461	9	treatment	treatment	NOUN
admet-3091	461	10	of	of	ADP
admet-3091	461	11	advanced	advanced	ADJ
admet-3091	461	12	prostate	prostate	NOUN
admet-3091	461	13	cancer	cancer	NOUN
admet-3091	461	14	.	.	PUNCT
admet-3091	462	1	the	the	DET
admet-3091	462	2	journal	journal	NOUN
admet-3091	462	3	of	of	ADP
admet-3091	462	4	urology	urology	NOUN
admet-3091	462	5	143	143	NUM
admet-3091	462	6	(	(	PUNCT
admet-3091	462	7	1990	1990	NUM
admet-3091	462	8	)	)	PUNCT
admet-3091	462	9	68	68	NUM
admet-3091	462	10	-	-	SYM
admet-3091	462	11	71	71	NUM
admet-3091	462	12	.	.	PUNCT
admet-3091	463	1	https://doi.org/10.1016/s0022-5347(17)39868-3	https://doi.org/10.1016/s0022-5347(17)39868-3	NOUN
admet-3091	464	1	[	[	X
admet-3091	464	2	56	56	NUM
admet-3091	464	3	]	]	X
admet-3091	464	4	d.	d.	PROPN
admet-3091	464	5	modi	modi	PROPN
admet-3091	464	6	,	,	PUNCT
admet-3091	464	7	m.s	m.s	PROPN
admet-3091	464	8	.	.	PROPN
admet-3091	464	9	hussain	hussain	PROPN
admet-3091	464	10	,	,	PUNCT
admet-3091	464	11	s.	s.	PROPN
admet-3091	464	12	ainampudi	ainampudi	PROPN
admet-3091	464	13	,	,	PUNCT
admet-3091	464	14	b.g	b.g	PROPN
admet-3091	464	15	.	.	PROPN
admet-3091	464	16	prajapati	prajapati	PROPN
admet-3091	464	17	.	.	PUNCT
admet-3091	465	1	long	long	ADJ
admet-3091	465	2	acting	act	VERB
admet-3091	465	3	injectables	injectable	NOUN
admet-3091	465	4	for	for	ADP
admet-3091	465	5	the	the	DET
admet-3091	465	6	treatment	treatment	NOUN
admet-3091	465	7	of	of	ADP
admet-3091	465	8	prostate	prostate	NOUN
admet-3091	465	9	cancer	cancer	NOUN
admet-3091	465	10	.	.	PUNCT
admet-3091	466	1	journal	journal	PROPN
admet-3091	466	2	of	of	ADP
admet-3091	466	3	drug	drug	NOUN
admet-3091	466	4	delivery	delivery	NOUN
admet-3091	466	5	science	science	NOUN
admet-3091	466	6	and	and	CCONJ
admet-3091	466	7	technology	technology	NOUN
admet-3091	466	8	100	100	NUM
admet-3091	466	9	(	(	PUNCT
admet-3091	466	10	2024	2024	NUM
admet-3091	466	11	)	)	PUNCT
admet-3091	466	12	105996	105996	NUM
admet-3091	466	13	.	.	PUNCT
admet-3091	467	1	https://doi.org/10.1016/j.jddst.2024.105996	https://doi.org/10.1016/j.jddst.2024.105996	PROPN
admet-3091	467	2	[	[	X
admet-3091	467	3	57	57	NUM
admet-3091	467	4	]	]	X
admet-3091	467	5	b.l	b.l	PROPN
admet-3091	467	6	.	.	PROPN
admet-3091	467	7	silverman	silverman	PROPN
admet-3091	467	8	,	,	PUNCT
admet-3091	467	9	s.	s.	PROPN
admet-3091	467	10	l.	l.	PROPN
admet-3091	467	11	,	,	PUNCT
admet-3091	467	12	blethen	blethen	ADV
admet-3091	467	13	,	,	PUNCT
admet-3091	467	14	e.o	e.o	PROPN
admet-3091	467	15	.	.	PROPN
admet-3091	467	16	reiter	reiter	PROPN
admet-3091	467	17	,	,	PUNCT
admet-3091	467	18	k.m	k.m	PROPN
admet-3091	467	19	.	.	PROPN
admet-3091	467	20	attie	attie	PROPN
admet-3091	467	21	,	,	PUNCT
admet-3091	467	22	r.b	r.b	PROPN
admet-3091	467	23	.	.	PROPN
admet-3091	467	24	neuwirth	neuwirth	PROPN
admet-3091	467	25	,	,	PUNCT
admet-3091	467	26	k.m	k.m	PROPN
admet-3091	467	27	.	.	PROPN
admet-3091	467	28	ford	ford	PROPN
admet-3091	467	29	.	.	PUNCT
admet-3091	468	1	a	a	DET
admet-3091	468	2	long	long	ADV
admet-3091	468	3	-	-	PUNCT
admet-3091	468	4	acting	act	VERB
admet-3091	468	5	human	human	ADJ
admet-3091	468	6	growth	growth	NOUN
admet-3091	468	7	hormone	hormone	NOUN
admet-3091	468	8	(	(	PUNCT
admet-3091	468	9	nutropin	nutropin	NOUN
admet-3091	468	10	depot	depot	NOUN
admet-3091	468	11	®	®	NOUN
admet-3091	468	12	):	):	PUNCT
admet-3091	468	13	efficacy	efficacy	NOUN
admet-3091	468	14	and	and	CCONJ
admet-3091	468	15	safety	safety	NOUN
admet-3091	468	16	following	follow	VERB
admet-3091	468	17	two	two	NUM
admet-3091	468	18	years	year	NOUN
admet-3091	468	19	of	of	ADP
admet-3091	468	20	treatment	treatment	NOUN
admet-3091	468	21	in	in	ADP
admet-3091	468	22	children	child	NOUN
admet-3091	468	23	with	with	ADP
admet-3091	468	24	growth	growth	NOUN
admet-3091	468	25	hormone	hormone	NOUN
admet-3091	468	26	deficiency	deficiency	NOUN
admet-3091	468	27	.	.	PUNCT
admet-3091	469	1	journal	journal	NOUN
admet-3091	469	2	of	of	ADP
admet-3091	469	3	pediatric	pediatric	ADJ
admet-3091	469	4	endocrinology	endocrinology	NOUN
admet-3091	469	5	and	and	CCONJ
admet-3091	469	6	metabolism	metabolism	NOUN
admet-3091	469	7	15	15	NUM
admet-3091	469	8	(	(	PUNCT
admet-3091	469	9	2002	2002	NUM
admet-3091	469	10	)	)	PUNCT
admet-3091	469	11	715722	715722	NUM
admet-3091	469	12	.	.	PUNCT
admet-3091	470	1	https://doi.org/10.1515/jpem.2002.15.s2.715	https://doi.org/10.1515/jpem.2002.15.s2.715	PROPN
admet-3091	470	2	[	[	X
admet-3091	470	3	58	58	NUM
admet-3091	470	4	]	]	PUNCT
admet-3091	470	5	i.	i.	PROPN
admet-3091	470	6	lancranjan	lancranjan	PROPN
admet-3091	470	7	,	,	PUNCT
admet-3091	470	8	c.	c.	PROPN
admet-3091	470	9	bruns	bruns	PROPN
admet-3091	470	10	,	,	PUNCT
admet-3091	470	11	p.	p.	NOUN
admet-3091	470	12	grass	grass	NOUN
admet-3091	470	13	,	,	PUNCT
admet-3091	470	14	p.jaquet	p.jaquet	NOUN
admet-3091	470	15	,	,	PUNCT
admet-3091	470	16	j.	j.	PROPN
admet-3091	470	17	jervell	jervell	PROPN
admet-3091	470	18	,	,	PUNCT
admet-3091	470	19	p.	p.	PROPN
admet-3091	470	20	kendall	kendall	PROPN
admet-3091	470	21	-	-	PUNCT
admet-3091	470	22	taylor	taylor	PROPN
admet-3091	470	23	,	,	PUNCT
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admet-3091	471	2	.	.	PUNCT
admet-3091	471	3	lamberts	lamberts	PROPN
admet-3091	471	4	,	,	PUNCT
admet-3091	471	5	p.	p.	NOUN
admet-3091	471	6	marbach	marbach	NOUN
admet-3091	471	7	,	,	PUNCT
admet-3091	471	8	h.	h.	PROPN
admet-3091	471	9	ørskov	ørskov	PROPN
admet-3091	471	10	,	,	PUNCT
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admet-3091	471	12	pagani	pagani	PROPN
admet-3091	471	13	,	,	PUNCT
admet-3091	471	14	m.	m.	NOUN
admet-3091	471	15	sheppard	sheppard	PROPN
admet-3091	471	16	.	.	PUNCT
admet-3091	472	1	sandostatin	sandostatin	PROPN
admet-3091	472	2	®	®	PROPN
admet-3091	472	3	lar	lar	PROPN
admet-3091	472	4	®	®	PROPN
admet-3091	472	5	:	:	PUNCT
admet-3091	472	6	a	a	DET
admet-3091	472	7	promising	promising	ADJ
admet-3091	472	8	therapeutic	therapeutic	ADJ
admet-3091	472	9	tool	tool	NOUN
admet-3091	472	10	in	in	ADP
admet-3091	472	11	the	the	DET
admet-3091	472	12	management	management	NOUN
admet-3091	472	13	of	of	ADP
admet-3091	472	14	acromegalic	acromegalic	ADJ
admet-3091	472	15	patients	patient	NOUN
admet-3091	472	16	.	.	PUNCT
admet-3091	473	1	metabolism	metabolism	NOUN
admet-3091	473	2	45	45	NUM
admet-3091	473	3	(	(	PUNCT
admet-3091	473	4	1996	1996	NUM
admet-3091	473	5	)	)	PUNCT
admet-3091	473	6	67	67	NUM
admet-3091	473	7	-	-	SYM
admet-3091	473	8	71	71	NUM
admet-3091	473	9	.	.	PUNCT
admet-3091	474	1	https://doi.org/10.1016/s0026-0495(96)90087-6	https://doi.org/10.1016/s0026-0495(96)90087-6	PROPN
admet-3091	475	1	[	[	X
admet-3091	475	2	59	59	NUM
admet-3091	475	3	]	]	X
admet-3091	475	4	l.p	l.p	PROPN
admet-3091	475	5	.	.	PROPN
admet-3091	475	6	icart	icart	PROPN
admet-3091	475	7	,	,	PUNCT
admet-3091	475	8	f.g	f.g	PROPN
admet-3091	475	9	.	.	PROPN
admet-3091	475	10	souza	souza	PROPN
admet-3091	475	11	jr	jr	PROPN
admet-3091	475	12	,	,	PUNCT
admet-3091	475	13	l.m.t	l.m.t	PROPN
admet-3091	475	14	.	.	PUNCT
admet-3091	476	1	lima	lima	PROPN
admet-3091	476	2	.	.	PUNCT
admet-3091	477	1	polymeric	polymeric	ADJ
admet-3091	477	2	microparticle	microparticle	NOUN
admet-3091	477	3	systems	system	NOUN
admet-3091	477	4	for	for	ADP
admet-3091	477	5	modified	modify	VERB
admet-3091	477	6	release	release	NOUN
admet-3091	477	7	of	of	ADP
admet-3091	477	8	glucagon	glucagon	NOUN
admet-3091	477	9	-	-	PUNCT
admet-3091	477	10	like	like	ADP
admet-3091	477	11	-	-	PUNCT
admet-3091	477	12	peptide-1	peptide-1	NOUN
admet-3091	477	13	receptor	receptor	NOUN
admet-3091	477	14	agonists	agonist	NOUN
admet-3091	477	15	.	.	PUNCT
admet-3091	478	1	journal	journal	NOUN
admet-3091	478	2	of	of	ADP
admet-3091	478	3	microencapsulation	microencapsulation	NOUN
admet-3091	478	4	38	38	NUM
admet-3091	478	5	(	(	PUNCT
admet-3091	478	6	2021	2021	NUM
admet-3091	478	7	)	)	PUNCT
admet-3091	478	8	249	249	NUM
admet-3091	478	9	-	-	SYM
admet-3091	478	10	261	261	NUM
admet-3091	478	11	.	.	PUNCT
admet-3091	478	12	https://doi.org/10.1080/02652048.2021.1889059	https://doi.org/10.1080/02652048.2021.1889059	PUNCT
admet-3091	479	1	[	[	X
admet-3091	479	2	60	60	NUM
admet-3091	479	3	]	]	X
admet-3091	479	4	m.c	m.c	PROPN
admet-3091	479	5	.	.	PROPN
admet-3091	479	6	operti	operti	PROPN
admet-3091	479	7	,	,	PUNCT
admet-3091	479	8	a.	a.	PROPN
admet-3091	479	9	bernhardt	bernhardt	PROPN
admet-3091	479	10	,	,	PUNCT
admet-3091	479	11	s.	s.	PROPN
admet-3091	479	12	grimm	grimm	PROPN
admet-3091	479	13	,	,	PUNCT
admet-3091	479	14	a.	a.	PROPN
admet-3091	479	15	engel	engel	PROPN
admet-3091	479	16	,	,	PUNCT
admet-3091	479	17	c.g	c.g	PROPN
admet-3091	479	18	.	.	PROPN
admet-3091	479	19	figdor	figdor	PROPN
admet-3091	479	20	,	,	PUNCT
admet-3091	479	21	o.	o.	PROPN
admet-3091	479	22	tagit	tagit	PROPN
admet-3091	479	23	.	.	PUNCT
admet-3091	480	1	plga	plga	NOUN
admet-3091	480	2	-	-	PUNCT
admet-3091	480	3	based	base	VERB
admet-3091	480	4	nanomedicines	nanomedicine	NOUN
admet-3091	480	5	manufacturing	manufacturing	NOUN
admet-3091	480	6	:	:	PUNCT
admet-3091	480	7	technologies	technology	NOUN
admet-3091	480	8	overview	overview	VERB
admet-3091	480	9	and	and	CCONJ
admet-3091	480	10	challenges	challenge	NOUN
admet-3091	480	11	in	in	ADP
admet-3091	480	12	industrial	industrial	ADJ
admet-3091	480	13	scale	scale	NOUN
admet-3091	480	14	-	-	PUNCT
admet-3091	480	15	up	up	NOUN
admet-3091	480	16	.	.	PUNCT
admet-3091	481	1	international	international	ADJ
admet-3091	481	2	journal	journal	PROPN
admet-3091	481	3	of	of	ADP
admet-3091	481	4	pharmaceutics	pharmaceutic	NOUN
admet-3091	481	5	605	605	NUM
admet-3091	481	6	(	(	PUNCT
admet-3091	481	7	2021	2021	NUM
admet-3091	481	8	)	)	PUNCT
admet-3091	481	9	120807	120807	NUM
admet-3091	481	10	.	.	PUNCT
admet-3091	482	1	https://doi.org/10.1016/j.ijpharm.2021.120807	https://doi.org/10.1016/j.ijpharm.2021.120807	PROPN
admet-3091	482	2	©	©	PROPN
admet-3091	482	3	2025	2025	NUM
admet-3091	482	4	by	by	ADP
admet-3091	482	5	the	the	DET
admet-3091	482	6	authors	author	NOUN
admet-3091	482	7	;	;	PUNCT
admet-3091	482	8	licensee	licensee	PROPN
admet-3091	482	9	iapc	iapc	PROPN
admet-3091	482	10	,	,	PUNCT
admet-3091	482	11	zagreb	zagreb	PROPN
admet-3091	482	12	,	,	PUNCT
admet-3091	482	13	croatia	croatia	PROPN
admet-3091	482	14	.	.	PUNCT
admet-3091	483	1	this	this	DET
admet-3091	483	2	article	article	NOUN
admet-3091	483	3	is	be	AUX
admet-3091	483	4	an	an	DET
admet-3091	483	5	open	open	ADJ
admet-3091	483	6	-	-	PUNCT
admet-3091	483	7	access	access	NOUN
admet-3091	483	8	article	article	NOUN
admet-3091	483	9	distributed	distribute	VERB
admet-3091	483	10	under	under	ADP
admet-3091	483	11	the	the	DET
admet-3091	483	12	terms	term	NOUN
admet-3091	483	13	and	and	CCONJ
admet-3091	483	14	conditions	condition	NOUN
admet-3091	483	15	of	of	ADP
admet-3091	483	16	the	the	DET
admet-3091	483	17	creative	creative	ADJ
admet-3091	483	18	commons	common	NOUN
admet-3091	483	19	attribution	attribution	NOUN
admet-3091	483	20	license	license	NOUN
admet-3091	483	21	(	(	PUNCT
admet-3091	483	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-3091	483	23	)	)	PUNCT
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admet-3091	483	27	https://doi.org/10.1016/s0022-5347(17)39868-3	https://doi.org/10.1016/s0022-5347(17)39868-3	PROPN
admet-3091	483	28	https://doi.org/10.1016/j.jddst.2024.105996	https://doi.org/10.1016/j.jddst.2024.105996	NOUN
admet-3091	483	29	https://doi.org/10.1515/jpem.2002.15.s2.715	https://doi.org/10.1515/jpem.2002.15.s2.715	PROPN
admet-3091	483	30	https://doi.org/10.1016/s0026-0495(96)90087-6	https://doi.org/10.1016/s0026-0495(96)90087-6	NOUN
admet-3091	483	31	https://doi.org/10.1080/02652048.2021.1889059	https://doi.org/10.1080/02652048.2021.1889059	PROPN
admet-3091	484	1	https://doi.org/10.1016/j.ijpharm.2021.120807	https://doi.org/10.1016/j.ijpharm.2021.120807	VERB
admet-3091	484	2	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN