id	sid	tid	token	lemma	pos
admet-31	1	1	manuscript	manuscript	PROPN
admet-31	1	2	doi	doi	PROPN
admet-31	1	3	:	:	PUNCT
admet-31	1	4	10.5599	10.5599	NUM
admet-31	1	5	/	/	SYM
admet-31	1	6	admet.2.1.31	admet.2.1.31	PROPN
admet-31	1	7	43	43	NUM
admet-31	1	8	admet	admet	NOUN
admet-31	1	9	&	&	CCONJ
admet-31	1	10	dmpk	dmpk	PROPN
admet-31	1	11	2(1	2(1	NUM
admet-31	1	12	)	)	PUNCT
admet-31	1	13	(	(	PUNCT
admet-31	1	14	2014	2014	NUM
admet-31	1	15	)	)	PUNCT
admet-31	1	16	43	43	NUM
admet-31	1	17	-	-	SYM
admet-31	1	18	55	55	NUM
admet-31	1	19	;	;	PUNCT
admet-31	1	20	doi	doi	NOUN
admet-31	1	21	:	:	PUNCT
admet-31	1	22	10.5599	10.5599	NUM
admet-31	1	23	/	/	SYM
admet-31	1	24	admet.2.1.31	admet.2.1.31	NOUN
admet-31	1	25	open	open	ADJ
admet-31	1	26	access	access	NOUN
admet-31	1	27	:	:	PUNCT
admet-31	1	28	issn	issn	PROPN
admet-31	1	29	:	:	PUNCT
admet-31	1	30	1848	1848	NUM
admet-31	1	31	-	-	SYM
admet-31	1	32	7718	7718	NUM
admet-31	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-31	1	34	original	original	ADJ
admet-31	1	35	scientific	scientific	ADJ
admet-31	1	36	paper	paper	NOUN
admet-31	1	37	phosphate	phosphate	NOUN
admet-31	1	38	precipitates	precipitate	NOUN
admet-31	1	39	and	and	CCONJ
admet-31	1	40	water	water	NOUN
admet-31	1	41	-	-	PUNCT
admet-31	1	42	soluble	soluble	ADJ
admet-31	1	43	aggregates	aggregate	NOUN
admet-31	1	44	in	in	ADP
admet-31	1	45	re	re	ADJ
admet-31	1	46	-	-	VERB
admet-31	1	47	analyzed	analyze	VERB
admet-31	1	48	solubility	solubility	NOUN
admet-31	1	49	-	-	PUNCT
admet-31	1	50	ph	ph	ADJ
admet-31	1	51	data	datum	NOUN
admet-31	1	52	of	of	ADP
admet-31	1	53	twenty	twenty	NUM
admet-31	1	54	-	-	PUNCT
admet-31	1	55	five	five	NUM
admet-31	1	56	basic	basic	ADJ
admet-31	1	57	drugs	drug	NOUN
admet-31	1	58	alex	alex	PROPN
admet-31	1	59	avdeef	avdeef	PROPN
admet-31	1	60	in	in	ADP
admet-31	1	61	-	-	PUNCT
admet-31	1	62	adme	adme	NOUN
admet-31	1	63	research	research	NOUN
admet-31	1	64	,	,	PUNCT
admet-31	1	65	1732	1732	NUM
admet-31	1	66	first	first	ADJ
admet-31	1	67	avenue	avenue	PROPN
admet-31	1	68	,	,	PUNCT
admet-31	1	69	#	#	SYM
admet-31	1	70	102	102	NUM
admet-31	1	71	,	,	PUNCT
admet-31	1	72	new	new	PROPN
admet-31	1	73	york	york	PROPN
admet-31	1	74	,	,	PUNCT
admet-31	1	75	ny	ny	PROPN
admet-31	1	76	10128	10128	NUM
admet-31	1	77	,	,	PUNCT
admet-31	1	78	usa	usa	PROPN
admet-31	1	79	e	e	PROPN
admet-31	1	80	-	-	NOUN
admet-31	1	81	mail	mail	NOUN
admet-31	1	82	:	:	PUNCT
admet-31	1	83	alex@in-adme.com	alex@in-adme.com	NOUN
admet-31	1	84	;	;	PUNCT
admet-31	1	85	tel	tel	PROPN
admet-31	1	86	.	.	PUNCT
admet-31	1	87	:	:	PUNCT
admet-31	2	1	+1	+1	PROPN
admet-31	2	2	646	646	NUM
admet-31	2	3	678	678	NUM
admet-31	2	4	5713	5713	NUM
admet-31	2	5	received	receive	VERB
admet-31	2	6	:	:	PUNCT
admet-31	2	7	february	february	NOUN
admet-31	2	8	15	15	NUM
admet-31	2	9	,	,	PUNCT
admet-31	2	10	2014	2014	NUM
admet-31	2	11	;	;	PUNCT
admet-31	2	12	revised	revise	VERB
admet-31	2	13	:	:	PUNCT
admet-31	2	14	march	march	PROPN
admet-31	2	15	12	12	NUM
admet-31	2	16	,	,	PUNCT
admet-31	2	17	2014	2014	NUM
admet-31	2	18	;	;	PUNCT
admet-31	2	19	published	publish	VERB
admet-31	2	20	:	:	PUNCT
admet-31	2	21	april	april	PROPN
admet-31	2	22	01	01	NUM
admet-31	2	23	,	,	PUNCT
admet-31	2	24	2014	2014	NUM
admet-31	2	25	abstract	abstract	NOUN
admet-31	2	26	the	the	DET
admet-31	2	27	purpose	purpose	NOUN
admet-31	2	28	of	of	ADP
admet-31	2	29	the	the	DET
admet-31	2	30	study	study	NOUN
admet-31	2	31	was	be	AUX
admet-31	2	32	to	to	PART
admet-31	2	33	assess	assess	VERB
admet-31	2	34	the	the	DET
admet-31	2	35	stoichiometries	stoichiometry	NOUN
admet-31	2	36	of	of	ADP
admet-31	2	37	phosphate	phosphate	ADJ
admet-31	2	38	precipitates	precipitate	NOUN
admet-31	2	39	and	and	CCONJ
admet-31	2	40	determine	determine	VERB
admet-31	2	41	the	the	DET
admet-31	2	42	intrinsic	intrinsic	ADJ
admet-31	2	43	solubilities	solubility	NOUN
admet-31	2	44	,	,	PUNCT
admet-31	2	45	s0	s0	PROPN
admet-31	2	46	,	,	PUNCT
admet-31	2	47	of	of	ADP
admet-31	2	48	25	25	NUM
admet-31	2	49	basic	basic	ADJ
admet-31	2	50	drugs	drug	NOUN
admet-31	2	51	from	from	ADP
admet-31	2	52	their	their	PRON
admet-31	2	53	published	publish	VERB
admet-31	2	54	solubility	solubility	NOUN
admet-31	2	55	-	-	PUNCT
admet-31	2	56	ph	ph	ADJ
admet-31	2	57	profiles	profile	NOUN
admet-31	2	58	in	in	ADP
admet-31	2	59	the	the	DET
admet-31	2	60	landmark	landmark	NOUN
admet-31	2	61	study	study	NOUN
admet-31	2	62	of	of	ADP
admet-31	2	63	bergström	bergström	NOUN
admet-31	2	64	et	et	PROPN
admet-31	2	65	al	al	PROPN
admet-31	2	66	.	.	PROPN
admet-31	2	67	(	(	PUNCT
admet-31	2	68	2004	2004	NUM
admet-31	2	69	)	)	PUNCT
admet-31	2	70	,	,	PUNCT
admet-31	2	71	where	where	SCONJ
admet-31	2	72	0.15	0.15	NUM
admet-31	2	73	m	m	NOUN
admet-31	2	74	phosphate	phosphate	NOUN
admet-31	2	75	buffer	buffer	NOUN
admet-31	2	76	media	medium	NOUN
admet-31	2	77	had	have	AUX
admet-31	2	78	been	be	AUX
admet-31	2	79	used	use	VERB
admet-31	2	80	.	.	PUNCT
admet-31	3	1	a	a	DET
admet-31	3	2	secondary	secondary	ADJ
admet-31	3	3	purpose	purpose	NOUN
admet-31	3	4	of	of	ADP
admet-31	3	5	this	this	DET
admet-31	3	6	study	study	NOUN
admet-31	3	7	was	be	AUX
admet-31	3	8	to	to	PART
admet-31	3	9	attempt	attempt	VERB
admet-31	3	10	to	to	PART
admet-31	3	11	predict	predict	VERB
admet-31	3	12	phosphate	phosphate	PROPN
admet-31	3	13	1:1	1:1	NUM
admet-31	3	14	and	and	CCONJ
admet-31	3	15	2:1	2:1	NUM
admet-31	3	16	solubility	solubility	NOUN
admet-31	3	17	products	product	NOUN
admet-31	3	18	,	,	PUNCT
admet-31	3	19	ksp	ksp	PROPN
admet-31	3	20	,	,	PUNCT
admet-31	3	21	from	from	ADP
admet-31	3	22	knowledge	knowledge	NOUN
admet-31	3	23	of	of	ADP
admet-31	3	24	s0	s0	PROPN
admet-31	3	25	.	.	PUNCT
admet-31	4	1	the	the	DET
admet-31	4	2	published	publish	VERB
admet-31	4	3	data	datum	NOUN
admet-31	4	4	have	have	AUX
admet-31	4	5	been	be	AUX
admet-31	4	6	re	re	VERB
admet-31	4	7	-	-	VERB
admet-31	4	8	analyzed	analyze	VERB
admet-31	4	9	using	use	VERB
admet-31	4	10	a	a	DET
admet-31	4	11	novel	novel	ADJ
admet-31	4	12	solubility	solubility	NOUN
admet-31	4	13	-	-	PUNCT
admet-31	4	14	ph	ph	NOUN
admet-31	4	15	analysis	analysis	NOUN
admet-31	4	16	computer	computer	NOUN
admet-31	4	17	program	program	NOUN
admet-31	4	18	,	,	PUNCT
admet-31	4	19	pdisol	pdisol	NOUN
admet-31	4	20	-	-	PUNCT
admet-31	4	21	x	x	NOUN
admet-31	4	22	tm	tm	NOUN
admet-31	4	23	.	.	PUNCT
admet-31	5	1	the	the	DET
admet-31	5	2	program	program	NOUN
admet-31	5	3	internally	internally	ADV
admet-31	5	4	derives	derive	VERB
admet-31	5	5	implicit	implicit	ADJ
admet-31	5	6	solubility	solubility	NOUN
admet-31	5	7	equations	equation	NOUN
admet-31	5	8	,	,	PUNCT
admet-31	5	9	given	give	VERB
admet-31	5	10	a	a	DET
admet-31	5	11	set	set	NOUN
admet-31	5	12	of	of	ADP
admet-31	5	13	proposed	propose	VERB
admet-31	5	14	equilibria	equilibrium	NOUN
admet-31	5	15	and	and	CCONJ
admet-31	5	16	constants	constant	NOUN
admet-31	5	17	(	(	PUNCT
admet-31	5	18	which	which	PRON
admet-31	5	19	are	be	AUX
admet-31	5	20	then	then	ADV
admet-31	5	21	iteratively	iteratively	ADV
admet-31	5	22	refined	refine	VERB
admet-31	5	23	by	by	ADP
admet-31	5	24	weighted	weight	VERB
admet-31	5	25	nonlinear	nonlinear	ADJ
admet-31	5	26	regression	regression	NOUN
admet-31	5	27	)	)	PUNCT
admet-31	5	28	,	,	PUNCT
admet-31	5	29	and	and	CCONJ
admet-31	5	30	does	do	AUX
admet-31	5	31	not	not	PART
admet-31	5	32	require	require	VERB
admet-31	5	33	explicit	explicit	ADJ
admet-31	5	34	henderson	henderson	PROPN
admet-31	5	35	-	-	PUNCT
admet-31	5	36	hasselbalch	hasselbalch	PROPN
admet-31	5	37	equations	equation	NOUN
admet-31	5	38	.	.	PUNCT
admet-31	6	1	the	the	DET
admet-31	6	2	data	datum	NOUN
admet-31	6	3	were	be	AUX
admet-31	6	4	tested	test	VERB
admet-31	6	5	for	for	ADP
admet-31	6	6	the	the	DET
admet-31	6	7	presence	presence	NOUN
admet-31	6	8	of	of	ADP
admet-31	6	9	phosphate	phosphate	ADJ
admet-31	6	10	precipitates	precipitate	NOUN
admet-31	6	11	of	of	ADP
admet-31	6	12	various	various	ADJ
admet-31	6	13	stoichiometries	stoichiometry	NOUN
admet-31	6	14	,	,	PUNCT
admet-31	6	15	as	as	ADV
admet-31	6	16	well	well	ADV
admet-31	6	17	as	as	ADP
admet-31	6	18	the	the	DET
admet-31	6	19	simultaneous	simultaneous	ADJ
admet-31	6	20	presence	presence	NOUN
admet-31	6	21	of	of	ADP
admet-31	6	22	aggregated	aggregate	VERB
admet-31	6	23	species	specie	NOUN
admet-31	6	24	,	,	PUNCT
admet-31	6	25	either	either	CCONJ
admet-31	6	26	cationic	cationic	ADJ
admet-31	6	27	or	or	CCONJ
admet-31	6	28	neutral	neutral	ADJ
admet-31	6	29	.	.	PUNCT
admet-31	7	1	the	the	DET
admet-31	7	2	presence	presence	NOUN
admet-31	7	3	of	of	ADP
admet-31	7	4	particular	particular	ADJ
admet-31	7	5	species	specie	NOUN
admet-31	7	6	was	be	AUX
admet-31	7	7	suggested	suggest	VERB
admet-31	7	8	by	by	ADP
admet-31	7	9	the	the	DET
admet-31	7	10	slope	slope	NOUN
admet-31	7	11	characteristics	characteristic	NOUN
admet-31	7	12	of	of	ADP
admet-31	7	13	the	the	DET
admet-31	7	14	log	log	NOUN
admet-31	7	15	s	s	X
admet-31	7	16	vs.	vs.	ADP
admet-31	7	17	ph	ph	ADJ
admet-31	7	18	curves	curve	NOUN
admet-31	7	19	.	.	PUNCT
admet-31	8	1	considerably	considerably	ADV
admet-31	8	2	different	different	ADJ
admet-31	8	3	intrinsic	intrinsic	ADJ
admet-31	8	4	solubility	solubility	NOUN
admet-31	8	5	constants	constant	NOUN
admet-31	8	6	were	be	AUX
admet-31	8	7	found	find	VERB
admet-31	8	8	,	,	PUNCT
admet-31	8	9	compared	compare	VERB
admet-31	8	10	to	to	ADP
admet-31	8	11	those	those	PRON
admet-31	8	12	originally	originally	ADV
admet-31	8	13	reported	report	VERB
admet-31	8	14	,	,	PUNCT
admet-31	8	15	for	for	ADP
admet-31	8	16	several	several	ADJ
admet-31	8	17	drugs	drug	NOUN
admet-31	8	18	(	(	PUNCT
admet-31	8	19	e.g.	e.g.	ADV
admet-31	8	20	,	,	PUNCT
admet-31	8	21	celiprolol	celiprolol	NOUN
admet-31	8	22	,	,	PUNCT
admet-31	8	23	desipramine	desipramine	NOUN
admet-31	8	24	,	,	PUNCT
admet-31	8	25	haloperidol	haloperidol	NOUN
admet-31	8	26	)	)	PUNCT
admet-31	8	27	.	.	PUNCT
admet-31	9	1	the	the	DET
admet-31	9	2	least	least	ADV
admet-31	9	3	soluble	soluble	ADJ
admet-31	9	4	molecule	molecule	NOUN
admet-31	9	5	,	,	PUNCT
admet-31	9	6	amiodarone	amiodarone	NOUN
admet-31	9	7	,	,	PUNCT
admet-31	9	8	analyzed	analyze	VERB
admet-31	9	9	to	to	PART
admet-31	9	10	have	have	VERB
admet-31	9	11	the	the	DET
admet-31	9	12	extraordinarily	extraordinarily	ADV
admet-31	9	13	low	low	ADJ
admet-31	9	14	intrinsic	intrinsic	ADJ
admet-31	9	15	solubility	solubility	NOUN
admet-31	9	16	of	of	ADP
admet-31	9	17	2	2	NUM
admet-31	9	18	picograms	picogram	NOUN
admet-31	9	19	/	/	SYM
admet-31	9	20	ml	ml	NOUN
admet-31	9	21	,	,	PUNCT
admet-31	9	22	a	a	DET
admet-31	9	23	moderate	moderate	ADJ
admet-31	9	24	salt	salt	NOUN
admet-31	9	25	solubility	solubility	NOUN
admet-31	9	26	of	of	ADP
admet-31	9	27	0.82	0.82	NUM
admet-31	9	28	mg	mg	NOUN
admet-31	9	29	/	/	SYM
admet-31	9	30	ml	ml	NOUN
admet-31	9	31	at	at	ADP
admet-31	9	32	the	the	DET
admet-31	9	33	gibbs	gibbs	PROPN
admet-31	9	34	-	-	PUNCT
admet-31	9	35	pka	pka	PROPN
admet-31	9	36	5.4	5.4	NUM
admet-31	9	37	,	,	PUNCT
admet-31	9	38	corresponding	correspond	VERB
admet-31	9	39	to	to	ADP
admet-31	9	40	the	the	DET
admet-31	9	41	species	specie	NOUN
admet-31	9	42	bh∙h2po4(s	bh∙h2po4(s	NOUN
admet-31	9	43	)	)	PUNCT
admet-31	9	44	,	,	PUNCT
admet-31	9	45	and	and	CCONJ
admet-31	9	46	a	a	DET
admet-31	9	47	substantial	substantial	ADJ
admet-31	9	48	presence	presence	NOUN
admet-31	9	49	of	of	ADP
admet-31	9	50	the	the	DET
admet-31	9	51	positively	positively	ADV
admet-31	9	52	-	-	PUNCT
admet-31	9	53	charged	charge	VERB
admet-31	9	54	pentameric	pentameric	NOUN
admet-31	9	55	aggregate	aggregate	NOUN
admet-31	9	56	,	,	PUNCT
admet-31	9	57	(	(	PUNCT
admet-31	9	58	bh)5	bh)5	NOUN
admet-31	9	59	.	.	PUNCT
admet-31	10	1	keywords	keyword	NOUN
admet-31	10	2	sparingly	sparingly	ADV
admet-31	10	3	-	-	PUNCT
admet-31	10	4	soluble	soluble	ADJ
admet-31	10	5	drugs	drug	NOUN
admet-31	10	6	;	;	PUNCT
admet-31	10	7	ph	ph	ADJ
admet-31	10	8	-	-	PUNCT
admet-31	10	9	dependent	dependent	ADJ
admet-31	10	10	solubility	solubility	NOUN
admet-31	10	11	;	;	PUNCT
admet-31	10	12	salt	salt	NOUN
admet-31	10	13	solubility	solubility	NOUN
admet-31	10	14	products	product	NOUN
admet-31	10	15	;	;	PUNCT
admet-31	10	16	prediction	prediction	NOUN
admet-31	10	17	of	of	ADP
admet-31	10	18	solubility	solubility	NOUN
admet-31	10	19	products	product	NOUN
admet-31	10	20	;	;	PUNCT
admet-31	10	21	solubility	solubility	NOUN
admet-31	10	22	equations	equation	NOUN
admet-31	10	23	;	;	PUNCT
admet-31	10	24	aggregation	aggregation	NOUN
admet-31	10	25	;	;	PUNCT
admet-31	10	26	miniaturized	miniaturize	VERB
admet-31	10	27	shake	shake	NOUN
admet-31	10	28	-	-	PUNCT
admet-31	10	29	flask	flask	NOUN
admet-31	10	30	method	method	NOUN
admet-31	10	31	.	.	PUNCT
admet-31	11	1	introduction	introduction	NOUN
admet-31	11	2	when	when	SCONJ
admet-31	11	3	sparingly	sparingly	ADV
admet-31	11	4	soluble	soluble	ADJ
admet-31	11	5	basic	basic	ADJ
admet-31	11	6	drugs	drug	NOUN
admet-31	11	7	are	be	AUX
admet-31	11	8	added	add	VERB
admet-31	11	9	in	in	ADP
admet-31	11	10	substantial	substantial	ADJ
admet-31	11	11	amount	amount	NOUN
admet-31	11	12	to	to	PART
admet-31	11	13	phosphate	phosphate	VERB
admet-31	11	14	-	-	PUNCT
admet-31	11	15	containing	contain	VERB
admet-31	11	16	buffer	buffer	NOUN
admet-31	11	17	solutions	solution	NOUN
admet-31	11	18	,	,	PUNCT
admet-31	11	19	there	there	PRON
admet-31	11	20	is	be	VERB
admet-31	11	21	likelihood	likelihood	NOUN
admet-31	11	22	that	that	SCONJ
admet-31	11	23	some	some	DET
admet-31	11	24	drugs	drug	NOUN
admet-31	11	25	will	will	AUX
admet-31	11	26	precipitate	precipitate	VERB
admet-31	11	27	as	as	ADP
admet-31	11	28	phosphate	phosphate	ADJ
admet-31	11	29	salts	salt	NOUN
admet-31	11	30	in	in	ADP
admet-31	11	31	neutral	neutral	ADJ
admet-31	11	32	or	or	CCONJ
admet-31	11	33	acidic	acidic	ADJ
admet-31	11	34	solutions	solution	NOUN
admet-31	11	35	.	.	PUNCT
admet-31	12	1	because	because	SCONJ
admet-31	12	2	the	the	DET
admet-31	12	3	buffer	buffer	NOUN
admet-31	12	4	can	can	AUX
admet-31	12	5	exist	exist	VERB
admet-31	12	6	in	in	ADP
admet-31	12	7	three	three	NUM
admet-31	12	8	negatively	negatively	ADV
admet-31	12	9	charged	charge	VERB
admet-31	12	10	overlapping	overlap	VERB
admet-31	12	11	forms	form	NOUN
admet-31	12	12	in	in	ADP
admet-31	12	13	solution	solution	NOUN
admet-31	12	14	,	,	PUNCT
admet-31	12	15	different	different	ADJ
admet-31	12	16	phosphate	phosphate	NOUN
admet-31	12	17	precipitates	precipitate	NOUN
admet-31	12	18	can	can	AUX
admet-31	12	19	form	form	VERB
admet-31	12	20	with	with	ADP
admet-31	12	21	positively	positively	ADV
admet-31	12	22	charged	charge	VERB
admet-31	12	23	ionizable	ionizable	ADJ
admet-31	12	24	drugs	drug	NOUN
admet-31	12	25	.	.	PUNCT
admet-31	13	1	the	the	DET
admet-31	13	2	process	process	NOUN
admet-31	13	3	is	be	AUX
admet-31	13	4	influenced	influence	VERB
admet-31	13	5	by	by	ADP
admet-31	13	6	the	the	DET
admet-31	13	7	solution	solution	NOUN
admet-31	13	8	ph	ph	VERB
admet-31	13	9	in	in	ADP
admet-31	13	10	relation	relation	NOUN
admet-31	13	11	to	to	ADP
admet-31	13	12	the	the	DET
admet-31	13	13	pka	pka	NOUN
admet-31	13	14	of	of	ADP
admet-31	13	15	the	the	DET
admet-31	13	16	drug	drug	NOUN
admet-31	13	17	.	.	PUNCT
admet-31	14	1	if	if	SCONJ
admet-31	14	2	an	an	DET
admet-31	14	3	appreciable	appreciable	ADJ
admet-31	14	4	amount	amount	NOUN
admet-31	14	5	of	of	ADP
admet-31	14	6	chloride	chloride	NOUN
admet-31	14	7	is	be	AUX
admet-31	14	8	also	also	ADV
admet-31	14	9	present	present	ADJ
admet-31	14	10	in	in	ADP
admet-31	14	11	solution	solution	NOUN
admet-31	14	12	,	,	PUNCT
admet-31	14	13	drug	drug	NOUN
admet-31	14	14	-	-	PUNCT
admet-31	14	15	chloride	chloride	NOUN
admet-31	14	16	precipitates	precipitate	NOUN
admet-31	14	17	may	may	AUX
admet-31	14	18	form	form	VERB
admet-31	14	19	in	in	ADP
admet-31	14	20	lieu	lieu	NOUN
admet-31	14	21	of	of	ADP
admet-31	14	22	,	,	PUNCT
admet-31	14	23	or	or	CCONJ
admet-31	14	24	along	along	ADP
admet-31	14	25	with	with	ADP
admet-31	14	26	phosphate	phosphate	ADJ
admet-31	14	27	precipitates	precipitate	NOUN
admet-31	14	28	.	.	PUNCT
admet-31	15	1	furthermore	furthermore	ADV
admet-31	15	2	,	,	PUNCT
admet-31	15	3	in	in	ADP
admet-31	15	4	parallel	parallel	NOUN
admet-31	15	5	to	to	ADP
admet-31	15	6	precipitation	precipitation	NOUN
admet-31	15	7	,	,	PUNCT
admet-31	15	8	formation	formation	NOUN
admet-31	15	9	of	of	ADP
admet-31	15	10	water	water	NOUN
admet-31	15	11	-	-	PUNCT
admet-31	15	12	soluble	soluble	ADJ
admet-31	15	13	oligomeric	oligomeric	ADJ
admet-31	15	14	drug	drug	NOUN
admet-31	15	15	and	and	CCONJ
admet-31	15	16	micelle	micelle	PROPN
admet-31	15	17	species	species	PROPN
admet-31	15	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-31	15	19	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-31	15	20	avdeef	avdeef	PROPN
admet-31	15	21	admet	admet	PROPN
admet-31	15	22	&	&	CCONJ
admet-31	15	23	dmpk	dmpk	PROPN
admet-31	15	24	2(1	2(1	NUM
admet-31	15	25	)	)	PUNCT
admet-31	15	26	(	(	PUNCT
admet-31	15	27	2014	2014	NUM
admet-31	15	28	)	)	PUNCT
admet-31	15	29	43	43	NUM
admet-31	15	30	-	-	SYM
admet-31	15	31	55	55	NUM
admet-31	15	32	44	44	NUM
admet-31	15	33	can	can	AUX
admet-31	15	34	substantially	substantially	ADV
admet-31	15	35	complicate	complicate	VERB
admet-31	15	36	the	the	DET
admet-31	15	37	interpretation	interpretation	NOUN
admet-31	15	38	of	of	ADP
admet-31	15	39	the	the	DET
admet-31	15	40	solubility	solubility	NOUN
admet-31	15	41	measurements	measurement	NOUN
admet-31	15	42	,	,	PUNCT
admet-31	15	43	especially	especially	ADV
admet-31	15	44	when	when	SCONJ
admet-31	15	45	the	the	DET
admet-31	15	46	drugs	drug	NOUN
admet-31	15	47	have	have	VERB
admet-31	15	48	more	more	ADJ
admet-31	15	49	than	than	ADP
admet-31	15	50	one	one	NUM
admet-31	15	51	pka	pka	NOUN
admet-31	15	52	.	.	PUNCT
admet-31	16	1	although	although	SCONJ
admet-31	16	2	such	such	ADJ
admet-31	16	3	systems	system	NOUN
admet-31	16	4	had	have	AUX
admet-31	16	5	been	be	AUX
admet-31	16	6	studied	study	VERB
admet-31	16	7	on	on	ADP
admet-31	16	8	a	a	DET
admet-31	16	9	specific	specific	ADJ
admet-31	16	10	case	case	NOUN
admet-31	16	11	-	-	PUNCT
admet-31	16	12	by	by	ADP
admet-31	16	13	-	-	PUNCT
admet-31	16	14	case	case	NOUN
admet-31	16	15	basis	basis	NOUN
admet-31	16	16	,	,	PUNCT
admet-31	16	17	general	general	ADJ
admet-31	16	18	computational	computational	ADJ
admet-31	16	19	approaches	approach	NOUN
admet-31	16	20	suitable	suitable	ADJ
admet-31	16	21	to	to	PART
admet-31	16	22	tackle	tackle	VERB
admet-31	16	23	the	the	DET
admet-31	16	24	above	above	ADJ
admet-31	16	25	complexity	complexity	NOUN
admet-31	16	26	had	have	AUX
admet-31	16	27	been	be	AUX
admet-31	16	28	scarce	scarce	ADJ
admet-31	16	29	.	.	PUNCT
admet-31	17	1	perhaps	perhaps	ADV
admet-31	17	2	as	as	ADP
admet-31	17	3	a	a	DET
admet-31	17	4	result	result	NOUN
admet-31	17	5	,	,	PUNCT
admet-31	17	6	the	the	DET
admet-31	17	7	need	need	NOUN
admet-31	17	8	for	for	ADP
admet-31	17	9	such	such	ADJ
admet-31	17	10	analyses	analysis	NOUN
admet-31	17	11	had	have	AUX
admet-31	17	12	not	not	PART
admet-31	17	13	been	be	AUX
admet-31	17	14	widely	widely	ADV
admet-31	17	15	appreciated	appreciate	VERB
admet-31	17	16	.	.	PUNCT
admet-31	18	1	yet	yet	ADV
admet-31	18	2	,	,	PUNCT
admet-31	18	3	quantitative	quantitative	ADJ
admet-31	18	4	analysis	analysis	NOUN
admet-31	18	5	of	of	ADP
admet-31	18	6	such	such	ADJ
admet-31	18	7	complex	complex	ADJ
admet-31	18	8	reactions	reaction	NOUN
admet-31	18	9	clearly	clearly	ADV
admet-31	18	10	would	would	AUX
admet-31	18	11	have	have	VERB
admet-31	18	12	beneficial	beneficial	ADJ
admet-31	18	13	impact	impact	NOUN
admet-31	18	14	in	in	ADP
admet-31	18	15	early	early	ADJ
admet-31	18	16	drug	drug	NOUN
admet-31	18	17	development	development	NOUN
admet-31	18	18	in	in	ADP
admet-31	18	19	terms	term	NOUN
admet-31	18	20	of	of	ADP
admet-31	18	21	clearer	clear	ADJ
admet-31	18	22	interpretations	interpretation	NOUN
admet-31	18	23	of	of	ADP
admet-31	18	24	mechanistic	mechanistic	ADJ
admet-31	18	25	dissolution	dissolution	NOUN
admet-31	18	26	studies	study	NOUN
admet-31	18	27	involving	involve	VERB
admet-31	18	28	salts	salt	NOUN
admet-31	18	29	of	of	ADP
admet-31	18	30	sparingly	sparingly	ADV
admet-31	18	31	soluble	soluble	ADJ
admet-31	18	32	drugs	drug	NOUN
admet-31	18	33	in	in	ADP
admet-31	18	34	complex	complex	ADJ
admet-31	18	35	media	medium	NOUN
admet-31	18	36	with	with	ADP
admet-31	18	37	which	which	PRON
admet-31	18	38	the	the	DET
admet-31	18	39	drugs	drug	NOUN
admet-31	18	40	can	can	AUX
admet-31	18	41	directly	directly	ADV
admet-31	18	42	interact	interact	VERB
admet-31	18	43	(	(	PUNCT
admet-31	18	44	e.g.	e.g.	ADV
admet-31	18	45	,	,	PUNCT
admet-31	18	46	such	such	ADJ
admet-31	18	47	as	as	ADP
admet-31	18	48	simulated	simulated	ADJ
admet-31	18	49	intestinal	intestinal	ADJ
admet-31	18	50	fluids	fluid	NOUN
admet-31	18	51	)	)	PUNCT
admet-31	19	1	[	[	X
admet-31	19	2	1	1	NUM
admet-31	19	3	-	-	SYM
admet-31	19	4	5	5	NUM
admet-31	19	5	]	]	PUNCT
admet-31	19	6	.	.	PUNCT
admet-31	20	1	since	since	SCONJ
admet-31	20	2	salt	salt	NOUN
admet-31	20	3	solubility	solubility	NOUN
admet-31	20	4	is	be	AUX
admet-31	20	5	a	a	DET
admet-31	20	6	conditional	conditional	ADJ
admet-31	20	7	constant	constant	ADJ
admet-31	20	8	,	,	PUNCT
admet-31	20	9	depending	depend	VERB
admet-31	20	10	on	on	ADP
admet-31	20	11	the	the	DET
admet-31	20	12	drug	drug	NOUN
admet-31	20	13	and	and	CCONJ
admet-31	20	14	the	the	DET
admet-31	20	15	specific	specific	ADJ
admet-31	20	16	counterion	counterion	NOUN
admet-31	20	17	concentrations	concentration	NOUN
admet-31	20	18	,	,	PUNCT
admet-31	20	19	the	the	DET
admet-31	20	20	determination	determination	NOUN
admet-31	20	21	of	of	ADP
admet-31	20	22	the	the	DET
admet-31	20	23	thermodynamic	thermodynamic	ADJ
admet-31	20	24	solubility	solubility	NOUN
admet-31	20	25	product	product	NOUN
admet-31	20	26	allows	allow	VERB
admet-31	20	27	for	for	ADP
admet-31	20	28	scalability	scalability	NOUN
admet-31	20	29	of	of	ADP
admet-31	20	30	salt	salt	NOUN
admet-31	20	31	effects	effect	NOUN
admet-31	20	32	across	across	ADP
admet-31	20	33	a	a	DET
admet-31	20	34	wide	wide	ADJ
admet-31	20	35	range	range	NOUN
admet-31	20	36	of	of	ADP
admet-31	20	37	concentrations	concentration	NOUN
admet-31	20	38	of	of	ADP
admet-31	20	39	substituents	substituent	NOUN
admet-31	20	40	in	in	ADP
admet-31	20	41	formulation	formulation	NOUN
admet-31	20	42	research	research	NOUN
admet-31	20	43	.	.	PUNCT
admet-31	21	1	in	in	ADP
admet-31	21	2	addition	addition	NOUN
admet-31	21	3	,	,	PUNCT
admet-31	21	4	the	the	DET
admet-31	21	5	formation	formation	NOUN
admet-31	21	6	of	of	ADP
admet-31	21	7	drug	drug	NOUN
admet-31	21	8	aggregates	aggregate	NOUN
admet-31	21	9	can	can	AUX
admet-31	21	10	have	have	VERB
admet-31	21	11	significant	significant	ADJ
admet-31	21	12	impact	impact	NOUN
admet-31	21	13	on	on	ADP
admet-31	21	14	measured	measure	VERB
admet-31	21	15	in	in	ADP
admet-31	21	16	vitro	vitro	X
admet-31	21	17	permeability	permeability	NOUN
admet-31	21	18	,	,	PUNCT
admet-31	21	19	since	since	SCONJ
admet-31	21	20	aqueous	aqueous	ADJ
admet-31	21	21	diffusivity	diffusivity	NOUN
admet-31	21	22	of	of	ADP
admet-31	21	23	compounds	compound	NOUN
admet-31	21	24	depends	depend	VERB
admet-31	21	25	on	on	ADP
admet-31	21	26	their	their	PRON
admet-31	21	27	size	size	NOUN
admet-31	21	28	,	,	PUNCT
admet-31	21	29	e.g.	e.g.	ADV
admet-31	21	30	,	,	PUNCT
admet-31	21	31	as	as	SCONJ
admet-31	21	32	was	be	AUX
admet-31	21	33	suggested	suggest	VERB
admet-31	21	34	in	in	ADP
admet-31	21	35	the	the	DET
admet-31	21	36	caco-2	caco-2	NUM
admet-31	21	37	study	study	NOUN
admet-31	21	38	of	of	ADP
admet-31	21	39	retinoic	retinoic	PROPN
admet-31	21	40	acid	acid	NOUN
admet-31	21	41	in	in	ADP
admet-31	21	42	neutral	neutral	ADJ
admet-31	21	43	solution	solution	NOUN
admet-31	22	1	[	[	X
admet-31	22	2	6	6	NUM
admet-31	22	3	]	]	PUNCT
admet-31	22	4	.	.	PUNCT
admet-31	23	1	there	there	PRON
admet-31	23	2	are	be	VERB
admet-31	23	3	numerous	numerous	ADJ
admet-31	23	4	reports	report	NOUN
admet-31	23	5	of	of	ADP
admet-31	23	6	aggregation	aggregation	NOUN
admet-31	23	7	forming	form	VERB
admet-31	23	8	systems	system	NOUN
admet-31	23	9	[	[	X
admet-31	23	10	1,5	1,5	NUM
admet-31	23	11	-	-	SYM
admet-31	23	12	12	12	NUM
admet-31	23	13	]	]	PUNCT
admet-31	23	14	.	.	PUNCT
admet-31	24	1	for	for	ADP
admet-31	24	2	example	example	NOUN
admet-31	24	3	,	,	PUNCT
admet-31	24	4	doxycycline	doxycycline	NOUN
admet-31	25	1	[	[	X
admet-31	25	2	8	8	NUM
admet-31	25	3	]	]	PUNCT
admet-31	25	4	,	,	PUNCT
admet-31	25	5	with	with	ADP
admet-31	25	6	intrinsic	intrinsic	ADJ
admet-31	25	7	solubility	solubility	NOUN
admet-31	25	8	s0	s0	PROPN
admet-31	25	9	0.72	0.72	NUM
admet-31	25	10	mg∙ml-1	mg∙ml-1	NOUN
admet-31	25	11	,	,	PUNCT
admet-31	25	12	at	at	ADP
admet-31	25	13	25	25	NUM
admet-31	25	14	°	°	NOUN
admet-31	25	15	c	c	NOUN
admet-31	25	16	in	in	ADP
admet-31	25	17	1	1	NUM
admet-31	25	18	m	m	NOUN
admet-31	25	19	nacl	nacl	ADJ
admet-31	25	20	/	/	SYM
admet-31	25	21	hcl	hcl	PROPN
admet-31	25	22	acidic	acidic	ADJ
admet-31	25	23	solutions	solution	NOUN
admet-31	25	24	,	,	PUNCT
admet-31	25	25	forms	form	VERB
admet-31	25	26	dimers	dimer	NOUN
admet-31	25	27	with	with	ADP
admet-31	25	28	k2	k2	PROPN
admet-31	25	29	=	=	PROPN
admet-31	25	30	24	24	NUM
admet-31	25	31	m-1	m-1	NUM
admet-31	25	32	.	.	PUNCT
admet-31	26	1	such	such	ADJ
admet-31	26	2	aggregates	aggregate	NOUN
admet-31	26	3	were	be	AUX
admet-31	26	4	found	find	VERB
admet-31	26	5	to	to	PART
admet-31	26	6	have	have	VERB
admet-31	26	7	unusually	unusually	ADV
admet-31	26	8	high	high	ADJ
admet-31	26	9	solubility	solubility	NOUN
admet-31	26	10	,	,	PUNCT
admet-31	26	11	sensitively	sensitively	ADV
admet-31	26	12	dependent	dependent	ADJ
admet-31	26	13	on	on	ADP
admet-31	26	14	temperature	temperature	NOUN
admet-31	26	15	.	.	PUNCT
admet-31	27	1	zhu	zhu	PROPN
admet-31	27	2	and	and	CCONJ
admet-31	27	3	streng	streng	PROPN
admet-31	28	1	[	[	X
admet-31	28	2	9	9	NUM
admet-31	28	3	]	]	PUNCT
admet-31	28	4	found	find	VERB
admet-31	28	5	that	that	SCONJ
admet-31	28	6	the	the	DET
admet-31	28	7	self	self	NOUN
admet-31	28	8	-	-	PUNCT
admet-31	28	9	association	association	NOUN
admet-31	28	10	of	of	ADP
admet-31	28	11	dolasetron	dolasetron	NOUN
admet-31	28	12	to	to	PART
admet-31	28	13	form	form	VERB
admet-31	28	14	cationic	cationic	ADJ
admet-31	28	15	dimers	dimer	NOUN
admet-31	28	16	and	and	CCONJ
admet-31	28	17	trimers	trimer	NOUN
admet-31	28	18	was	be	AUX
admet-31	28	19	enthalpy	enthalpy	NOUN
admet-31	28	20	driven	drive	VERB
admet-31	28	21	(	(	PUNCT
admet-31	28	22	h	h	NOUN
admet-31	28	23	-	-	PUNCT
admet-31	28	24	bond	bond	NOUN
admet-31	28	25	/	/	SYM
admet-31	28	26	aromatic	aromatic	ADJ
admet-31	28	27	ring	ring	NOUN
admet-31	28	28	rather	rather	ADV
admet-31	28	29	than	than	ADP
admet-31	28	30	hydrophobic	hydrophobic	NOUN
admet-31	28	31	/	/	SYM
admet-31	28	32	electrostatic	electrostatic	ADJ
admet-31	28	33	interactions	interaction	NOUN
admet-31	28	34	)	)	PUNCT
admet-31	28	35	,	,	PUNCT
admet-31	28	36	with	with	ADP
admet-31	28	37	the	the	DET
admet-31	28	38	aggregation	aggregation	NOUN
admet-31	28	39	constants	constant	NOUN
admet-31	28	40	,	,	PUNCT
admet-31	28	41	k2	k2	NOUN
admet-31	28	42	-	-	PUNCT
admet-31	28	43	3	3	NUM
admet-31	28	44	,	,	PUNCT
admet-31	28	45	ranging	range	VERB
admet-31	28	46	from	from	ADP
admet-31	28	47	4	4	NUM
admet-31	28	48	to	to	PART
admet-31	28	49	50	50	NUM
admet-31	28	50	m	m	NOUN
admet-31	28	51	-1	-1	ADJ
admet-31	28	52	at	at	ADP
admet-31	28	53	25	25	NUM
admet-31	28	54	°	°	NOUN
admet-31	28	55	c	c	NOUN
admet-31	28	56	.	.	PUNCT
admet-31	29	1	many	many	ADJ
admet-31	29	2	nonsteroidal	nonsteroidal	NOUN
admet-31	29	3	antiinflammatory	antiinflammatory	NOUN
admet-31	29	4	drugs	drug	NOUN
admet-31	29	5	[	[	X
admet-31	29	6	10	10	NUM
admet-31	29	7	]	]	X
admet-31	29	8	,	,	PUNCT
admet-31	29	9	such	such	ADJ
admet-31	29	10	as	as	ADP
admet-31	29	11	indomethacin	indomethacin	NOUN
admet-31	29	12	,	,	PUNCT
admet-31	29	13	diclofenac	diclofenac	NOUN
admet-31	29	14	,	,	PUNCT
admet-31	29	15	ibuprofen	ibuprofen	NOUN
admet-31	29	16	,	,	PUNCT
admet-31	29	17	ketoprofen	ketoprofen	NOUN
admet-31	29	18	,	,	PUNCT
admet-31	29	19	naproxen	naproxen	NOUN
admet-31	29	20	,	,	PUNCT
admet-31	29	21	and	and	CCONJ
admet-31	29	22	sulindac	sulindac	NOUN
admet-31	29	23	,	,	PUNCT
admet-31	29	24	can	can	AUX
admet-31	29	25	self	self	NOUN
admet-31	29	26	-	-	PUNCT
admet-31	29	27	associate	associate	NOUN
admet-31	29	28	by	by	ADP
admet-31	29	29	forming	form	VERB
admet-31	29	30	mixed	mixed	ADJ
admet-31	29	31	-	-	PUNCT
admet-31	29	32	charge	charge	NOUN
admet-31	29	33	micelle	micelle	NOUN
admet-31	29	34	or	or	CCONJ
admet-31	29	35	micelle	micelle	NOUN
admet-31	29	36	-	-	PUNCT
admet-31	29	37	like	like	ADJ
admet-31	29	38	structures	structure	NOUN
admet-31	29	39	.	.	PUNCT
admet-31	30	1	the	the	DET
admet-31	30	2	reported	report	VERB
admet-31	30	3	cmc	cmc	NOUN
admet-31	30	4	of	of	ADP
admet-31	30	5	diclofenac	diclofenac	NOUN
admet-31	30	6	is	be	AUX
admet-31	30	7	about	about	ADV
admet-31	30	8	25	25	NUM
admet-31	30	9	mm	mm	NOUN
admet-31	30	10	and	and	CCONJ
admet-31	30	11	of	of	ADP
admet-31	30	12	ketoprofen	ketoprofen	NOUN
admet-31	30	13	is	be	AUX
admet-31	30	14	about	about	ADV
admet-31	30	15	160	160	NUM
admet-31	30	16	mm	mm	NOUN
admet-31	31	1	[	[	X
admet-31	31	2	10	10	NUM
admet-31	31	3	]	]	PUNCT
admet-31	31	4	.	.	PUNCT
admet-31	32	1	the	the	DET
admet-31	32	2	re	re	NOUN
admet-31	32	3	-	-	NOUN
admet-31	32	4	analysis	analysis	NOUN
admet-31	32	5	of	of	ADP
admet-31	32	6	the	the	DET
admet-31	32	7	data	datum	NOUN
admet-31	32	8	of	of	ADP
admet-31	32	9	higuchi	higuchi	PROPN
admet-31	32	10	et	et	PROPN
admet-31	32	11	al	al	PROPN
admet-31	32	12	.	.	PUNCT
admet-31	33	1	[	[	X
admet-31	33	2	7	7	X
admet-31	33	3	]	]	PUNCT
admet-31	33	4	indicated	indicate	VERB
admet-31	33	5	that	that	SCONJ
admet-31	33	6	barbital	barbital	ADJ
admet-31	33	7	and	and	CCONJ
admet-31	33	8	phenobarbital	phenobarbital	ADJ
admet-31	33	9	likely	likely	ADV
admet-31	33	10	formed	form	VERB
admet-31	33	11	anionic	anionic	ADJ
admet-31	33	12	dimers	dimer	NOUN
admet-31	33	13	(	(	PUNCT
admet-31	33	14	reaching	reach	VERB
admet-31	33	15	peak	peak	NOUN
admet-31	33	16	concentrations	concentration	NOUN
admet-31	33	17	near	near	ADP
admet-31	33	18	ph	ph	ADJ
admet-31	33	19	8)	8)	NUM
admet-31	33	20	,	,	PUNCT
admet-31	33	21	whereas	whereas	SCONJ
admet-31	33	22	oxytetracycline	oxytetracycline	NOUN
admet-31	33	23	showed	show	VERB
admet-31	33	24	a	a	DET
admet-31	33	25	pronounced	pronounced	ADJ
admet-31	33	26	tendency	tendency	NOUN
admet-31	33	27	to	to	PART
admet-31	33	28	form	form	VERB
admet-31	33	29	a	a	DET
admet-31	33	30	cationic	cationic	ADJ
admet-31	33	31	dimer	dimer	NOUN
admet-31	33	32	(	(	PUNCT
admet-31	33	33	peaking	peak	VERB
admet-31	33	34	near	near	ADP
admet-31	33	35	ph	ph	ADJ
admet-31	33	36	2	2	NUM
admet-31	33	37	)	)	PUNCT
admet-31	34	1	[	[	X
admet-31	34	2	11	11	NUM
admet-31	34	3	]	]	PUNCT
admet-31	34	4	.	.	PUNCT
admet-31	35	1	saturated	saturate	VERB
admet-31	35	2	alkaline	alkaline	NOUN
admet-31	35	3	solutions	solution	NOUN
admet-31	35	4	of	of	ADP
admet-31	35	5	diprenorphine	diprenorphine	NOUN
admet-31	35	6	(	(	PUNCT
admet-31	35	7	ph	ph	NOUN
admet-31	35	8	>	>	X
admet-31	35	9	9	9	NUM
admet-31	35	10	)	)	PUNCT
admet-31	35	11	appeared	appear	VERB
admet-31	35	12	to	to	PART
admet-31	35	13	suggest	suggest	VERB
admet-31	35	14	the	the	DET
admet-31	35	15	formation	formation	NOUN
admet-31	35	16	of	of	ADP
admet-31	35	17	a	a	DET
admet-31	35	18	mixedcharge	mixedcharge	NOUN
admet-31	35	19	anionic	anionic	ADJ
admet-31	35	20	dimer	dimer	NOUN
admet-31	36	1	[	[	X
admet-31	36	2	12	12	NUM
admet-31	36	3	]	]	PUNCT
admet-31	36	4	.	.	PUNCT
admet-31	37	1	in	in	ADP
admet-31	37	2	these	these	DET
admet-31	37	3	and	and	CCONJ
admet-31	37	4	many	many	ADJ
admet-31	37	5	other	other	ADJ
admet-31	37	6	similar	similar	ADJ
admet-31	37	7	studies	study	NOUN
admet-31	37	8	,	,	PUNCT
admet-31	37	9	it	it	PRON
admet-31	37	10	is	be	AUX
admet-31	37	11	evident	evident	ADJ
admet-31	37	12	that	that	SCONJ
admet-31	37	13	the	the	DET
admet-31	37	14	solubility	solubility	NOUN
admet-31	37	15	-	-	PUNCT
admet-31	37	16	ph	ph	NOUN
admet-31	37	17	profiles	profile	NOUN
admet-31	37	18	can	can	AUX
admet-31	37	19	not	not	PART
admet-31	37	20	be	be	AUX
admet-31	37	21	described	describe	VERB
admet-31	37	22	accurately	accurately	ADV
admet-31	37	23	with	with	ADP
admet-31	37	24	the	the	DET
admet-31	37	25	henderson	henderson	PROPN
admet-31	37	26	-	-	PUNCT
admet-31	37	27	hasselbalch	hasselbalch	PROPN
admet-31	37	28	equation	equation	NOUN
admet-31	37	29	when	when	SCONJ
admet-31	37	30	aggregates	aggregate	NOUN
admet-31	37	31	form	form	VERB
admet-31	37	32	[	[	X
admet-31	37	33	1,5,11	1,5,11	NUM
admet-31	37	34	-	-	SYM
admet-31	37	35	13	13	NUM
admet-31	37	36	]	]	PUNCT
admet-31	37	37	.	.	PUNCT
admet-31	38	1	this	this	DET
admet-31	38	2	manuscript	manuscript	NOUN
admet-31	38	3	is	be	AUX
admet-31	38	4	the	the	DET
admet-31	38	5	third	third	ADJ
admet-31	38	6	contribution	contribution	NOUN
admet-31	38	7	in	in	ADP
admet-31	38	8	a	a	DET
admet-31	38	9	series	series	NOUN
admet-31	38	10	of	of	ADP
admet-31	38	11	studies	study	NOUN
admet-31	38	12	applying	apply	VERB
admet-31	38	13	a	a	DET
admet-31	38	14	new	new	ADJ
admet-31	38	15	salt	salt	NOUN
admet-31	38	16	solubility	solubility	NOUN
admet-31	38	17	analysis	analysis	NOUN
admet-31	38	18	,	,	PUNCT
admet-31	38	19	refinement	refinement	NOUN
admet-31	38	20	,	,	PUNCT
admet-31	38	21	and	and	CCONJ
admet-31	38	22	simulation	simulation	NOUN
admet-31	38	23	computer	computer	NOUN
admet-31	38	24	program	program	NOUN
admet-31	38	25	,	,	PUNCT
admet-31	38	26	pdisol	pdisol	ADV
admet-31	38	27	-	-	PUNCT
admet-31	38	28	xtm	xtm	PROPN
admet-31	38	29	(	(	PUNCT
admet-31	38	30	in	in	ADP
admet-31	38	31	-	-	PUNCT
admet-31	38	32	adme	adme	NOUN
admet-31	38	33	research	research	NOUN
admet-31	38	34	)	)	PUNCT
admet-31	38	35	,	,	PUNCT
admet-31	38	36	to	to	ADP
admet-31	38	37	the	the	DET
admet-31	38	38	study	study	NOUN
admet-31	38	39	of	of	ADP
admet-31	38	40	nonhenderson	nonhenderson	NOUN
admet-31	38	41	-	-	PUNCT
admet-31	38	42	hasselbalch	hasselbalch	NOUN
admet-31	38	43	behaving	behave	VERB
admet-31	38	44	solubility	solubility	NOUN
admet-31	38	45	systems	system	NOUN
admet-31	38	46	[	[	X
admet-31	38	47	11,12	11,12	NUM
admet-31	38	48	]	]	PUNCT
admet-31	38	49	.	.	PUNCT
admet-31	39	1	the	the	DET
admet-31	39	2	main	main	ADJ
admet-31	39	3	objective	objective	NOUN
admet-31	39	4	of	of	ADP
admet-31	39	5	this	this	DET
admet-31	39	6	brief	brief	ADJ
admet-31	39	7	commentary	commentary	NOUN
admet-31	39	8	is	be	AUX
admet-31	39	9	to	to	PART
admet-31	39	10	assess	assess	VERB
admet-31	39	11	the	the	DET
admet-31	39	12	stoichiometries	stoichiometry	NOUN
admet-31	39	13	of	of	ADP
admet-31	39	14	phosphate	phosphate	ADJ
admet-31	39	15	precipitates	precipitate	NOUN
admet-31	39	16	and	and	CCONJ
admet-31	39	17	determine	determine	VERB
admet-31	39	18	the	the	DET
admet-31	39	19	intrinsic	intrinsic	ADJ
admet-31	39	20	solubilities	solubility	NOUN
admet-31	39	21	,	,	PUNCT
admet-31	39	22	s0	s0	PROPN
admet-31	39	23	,	,	PUNCT
admet-31	39	24	of	of	ADP
admet-31	39	25	25	25	NUM
admet-31	39	26	basic	basic	ADJ
admet-31	39	27	drugs	drug	NOUN
admet-31	39	28	from	from	ADP
admet-31	39	29	their	their	PRON
admet-31	39	30	published	publish	VERB
admet-31	39	31	solubility	solubility	NOUN
admet-31	39	32	-	-	PUNCT
admet-31	39	33	ph	ph	ADJ
admet-31	39	34	profiles	profile	NOUN
admet-31	39	35	in	in	ADP
admet-31	39	36	the	the	DET
admet-31	39	37	landmark	landmark	NOUN
admet-31	39	38	study	study	NOUN
admet-31	39	39	of	of	ADP
admet-31	39	40	bergström	bergström	NOUN
admet-31	39	41	et	et	PROPN
admet-31	39	42	al	al	PROPN
admet-31	39	43	.	.	PUNCT
admet-31	40	1	[	[	X
admet-31	40	2	13	13	NUM
admet-31	40	3	]	]	PUNCT
admet-31	40	4	,	,	PUNCT
admet-31	40	5	where	where	SCONJ
admet-31	40	6	0.15	0.15	NUM
admet-31	40	7	m	m	NOUN
admet-31	40	8	phosphate	phosphate	NOUN
admet-31	40	9	buffer	buffer	NOUN
admet-31	40	10	media	medium	NOUN
admet-31	40	11	had	have	AUX
admet-31	40	12	been	be	AUX
admet-31	40	13	used	use	VERB
admet-31	40	14	.	.	PUNCT
admet-31	41	1	a	a	DET
admet-31	41	2	parallel	parallel	ADJ
admet-31	41	3	purpose	purpose	NOUN
admet-31	41	4	of	of	ADP
admet-31	41	5	the	the	DET
admet-31	41	6	study	study	NOUN
admet-31	41	7	was	be	AUX
admet-31	41	8	to	to	PART
admet-31	41	9	attempt	attempt	VERB
admet-31	41	10	to	to	PART
admet-31	41	11	predict	predict	VERB
admet-31	41	12	the	the	DET
admet-31	41	13	1:1	1:1	NUM
admet-31	41	14	and	and	CCONJ
admet-31	41	15	2:1	2:1	NUM
admet-31	41	16	phosphate	phosphate	NOUN
admet-31	41	17	solubility	solubility	NOUN
admet-31	41	18	products	product	NOUN
admet-31	41	19	,	,	PUNCT
admet-31	41	20	ksp	ksp	PROPN
admet-31	41	21	,	,	PUNCT
admet-31	41	22	from	from	ADP
admet-31	41	23	knowledge	knowledge	NOUN
admet-31	41	24	of	of	ADP
admet-31	41	25	s0	s0	PROPN
admet-31	41	26	,	,	PUNCT
admet-31	41	27	something	something	PRON
admet-31	41	28	that	that	PRON
admet-31	41	29	had	have	AUX
admet-31	41	30	not	not	PART
admet-31	41	31	been	be	AUX
admet-31	41	32	done	do	VERB
admet-31	41	33	hitherto	hitherto	NOUN
admet-31	41	34	,	,	PUNCT
admet-31	41	35	as	as	ADV
admet-31	41	36	far	far	ADV
admet-31	41	37	as	as	SCONJ
admet-31	41	38	we	we	PRON
admet-31	41	39	know	know	VERB
admet-31	41	40	.	.	PUNCT
admet-31	42	1	experimental	experimental	ADJ
admet-31	42	2	legacy	legacy	NOUN
admet-31	42	3	data	datum	NOUN
admet-31	42	4	in	in	ADP
admet-31	42	5	the	the	DET
admet-31	42	6	bergström	bergström	NOUN
admet-31	42	7	et	et	PROPN
admet-31	42	8	al	al	PROPN
admet-31	42	9	.	.	PUNCT
admet-31	43	1	[	[	X
admet-31	43	2	13	13	NUM
admet-31	43	3	]	]	PUNCT
admet-31	43	4	study	study	NOUN
admet-31	43	5	,	,	PUNCT
admet-31	43	6	the	the	DET
admet-31	43	7	solubility	solubility	NOUN
admet-31	43	8	experiments	experiment	NOUN
admet-31	43	9	were	be	AUX
admet-31	43	10	performed	perform	VERB
admet-31	43	11	at	at	ADP
admet-31	43	12	23	23	NUM
admet-31	43	13	°	°	NOUN
admet-31	43	14	c	c	NOUN
admet-31	43	15	,	,	PUNCT
admet-31	43	16	using	use	VERB
admet-31	43	17	a	a	DET
admet-31	43	18	miniaturized	miniaturize	VERB
admet-31	43	19	shake	shake	NOUN
admet-31	43	20	flask	flask	NOUN
admet-31	43	21	method	method	NOUN
admet-31	43	22	.	.	PUNCT
admet-31	44	1	each	each	DET
admet-31	44	2	drug	drug	NOUN
admet-31	44	3	was	be	AUX
admet-31	44	4	added	add	VERB
admet-31	44	5	in	in	ADP
admet-31	44	6	excess	excess	ADJ
admet-31	44	7	to	to	PART
admet-31	44	8	0.05	0.05	NUM
admet-31	44	9	-	-	PUNCT
admet-31	44	10	0.2	0.2	NUM
admet-31	44	11	�	�	NOUN
admet-31	44	12	ml	ml	ADP
admet-31	44	13	of	of	ADP
admet-31	44	14	0.15	0.15	NUM
admet-31	44	15	m	m	NOUN
admet-31	44	16	phosphate	phosphate	ADJ
admet-31	44	17	buffer	buffer	NOUN
admet-31	44	18	.	.	PUNCT
admet-31	45	1	the	the	DET
admet-31	45	2	ph	ph	NOUN
admet-31	45	3	of	of	ADP
admet-31	45	4	each	each	DET
admet-31	45	5	drug	drug	NOUN
admet-31	45	6	suspension	suspension	NOUN
admet-31	45	7	was	be	AUX
admet-31	45	8	then	then	ADV
admet-31	45	9	adjusted	adjust	VERB
admet-31	45	10	using	use	VERB
admet-31	45	11	solutions	solution	NOUN
admet-31	45	12	of	of	ADP
admet-31	45	13	h3po4	h3po4	NOUN
admet-31	45	14	or	or	CCONJ
admet-31	45	15	koh	koh	PROPN
admet-31	45	16	to	to	ADP
admet-31	45	17	a	a	DET
admet-31	45	18	selected	select	VERB
admet-31	45	19	ph	ph	NOUN
admet-31	45	20	(	(	PUNCT
admet-31	45	21	in	in	ADP
admet-31	45	22	some	some	DET
admet-31	45	23	cases	case	NOUN
admet-31	45	24	as	as	ADV
admet-31	45	25	low	low	ADJ
admet-31	45	26	as	as	ADP
admet-31	45	27	1.5	1.5	NUM
admet-31	45	28	and	and	CCONJ
admet-31	45	29	as	as	ADV
admet-31	45	30	high	high	ADJ
admet-31	45	31	as	as	ADP
admet-31	45	32	12	12	NUM
admet-31	45	33	)	)	PUNCT
admet-31	45	34	.	.	PUNCT
admet-31	46	1	the	the	DET
admet-31	46	2	suspensions	suspension	NOUN
admet-31	46	3	were	be	AUX
admet-31	46	4	then	then	ADV
admet-31	46	5	agitated	agitated	ADJ
admet-31	46	6	at	at	ADP
admet-31	46	7	300	300	NUM
admet-31	46	8	rpm	rpm	NOUN
admet-31	46	9	on	on	ADP
admet-31	46	10	a	a	DET
admet-31	46	11	admet	admet	NOUN
admet-31	46	12	&	&	CCONJ
admet-31	46	13	dmpk	dmpk	PROPN
admet-31	46	14	2(1	2(1	NUM
admet-31	46	15	)	)	PUNCT
admet-31	46	16	(	(	PUNCT
admet-31	46	17	2014	2014	NUM
admet-31	46	18	)	)	PUNCT
admet-31	46	19	43	43	NUM
admet-31	46	20	-	-	SYM
admet-31	46	21	55	55	NUM
admet-31	46	22	phosphate	phosphate	NOUN
admet-31	46	23	precipitates	precipitate	NOUN
admet-31	46	24	&	&	CCONJ
admet-31	46	25	aggregates	aggregate	NOUN
admet-31	46	26	of	of	ADP
admet-31	46	27	basic	basic	ADJ
admet-31	46	28	drugs	drug	NOUN
admet-31	46	29	doi	doi	NOUN
admet-31	46	30	:	:	PUNCT
admet-31	46	31	10.5599	10.5599	NUM
admet-31	46	32	/	/	SYM
admet-31	46	33	admet.2.1.31	admet.2.1.31	PROPN
admet-31	46	34	45	45	NUM
admet-31	46	35	plate	plate	NOUN
admet-31	46	36	shaker	shaker	NOUN
admet-31	46	37	for	for	ADP
admet-31	46	38	24	24	NUM
admet-31	46	39	h	h	NOUN
admet-31	46	40	,	,	PUNCT
admet-31	46	41	the	the	DET
admet-31	46	42	assigned	assign	VERB
admet-31	46	43	equilibration	equilibration	NOUN
admet-31	46	44	time	time	NOUN
admet-31	46	45	.	.	PUNCT
admet-31	47	1	after	after	ADP
admet-31	47	2	24	24	NUM
admet-31	47	3	h	h	NOUN
admet-31	47	4	,	,	PUNCT
admet-31	47	5	the	the	DET
admet-31	47	6	samples	sample	NOUN
admet-31	47	7	were	be	AUX
admet-31	47	8	centrifuged	centrifuge	VERB
admet-31	47	9	to	to	PART
admet-31	47	10	separate	separate	VERB
admet-31	47	11	the	the	DET
admet-31	47	12	precipitate	precipitate	NOUN
admet-31	47	13	from	from	ADP
admet-31	47	14	the	the	DET
admet-31	47	15	solution	solution	NOUN
admet-31	47	16	.	.	PUNCT
admet-31	48	1	the	the	DET
admet-31	48	2	drug	drug	NOUN
admet-31	48	3	concentration	concentration	NOUN
admet-31	48	4	in	in	ADP
admet-31	48	5	the	the	DET
admet-31	48	6	supernatant	supernatant	NOUN
admet-31	48	7	was	be	AUX
admet-31	48	8	analyzed	analyze	VERB
admet-31	48	9	by	by	ADP
admet-31	48	10	hplc	hplc	NOUN
admet-31	48	11	(	(	PUNCT
admet-31	48	12	uv	uv	NOUN
admet-31	48	13	/	/	SYM
admet-31	48	14	fluorescence	fluorescence	NOUN
admet-31	48	15	detection	detection	NOUN
admet-31	48	16	)	)	PUNCT
admet-31	48	17	.	.	PUNCT
admet-31	49	1	light	light	ADJ
admet-31	49	2	scattering	scatter	VERB
admet-31	49	3	measurements	measurement	NOUN
admet-31	49	4	did	do	AUX
admet-31	49	5	not	not	PART
admet-31	49	6	find	find	VERB
admet-31	49	7	colloidal	colloidal	NOUN
admet-31	49	8	particulates	particulate	NOUN
admet-31	49	9	or	or	CCONJ
admet-31	49	10	agglomerates	agglomerate	NOUN
admet-31	49	11	in	in	ADP
admet-31	49	12	the	the	DET
admet-31	49	13	supernatant	supernatant	NOUN
admet-31	49	14	.	.	PUNCT
admet-31	50	1	practically	practically	ADV
admet-31	50	2	insoluble	insoluble	ADJ
admet-31	50	3	amiodarone	amiodarone	NOUN
admet-31	50	4	,	,	PUNCT
admet-31	50	5	carvedilol	carvedilol	NOUN
admet-31	50	6	and	and	CCONJ
admet-31	50	7	mifepristone	mifepristone	NOUN
admet-31	50	8	could	could	AUX
admet-31	50	9	not	not	PART
admet-31	50	10	be	be	AUX
admet-31	50	11	detected	detect	VERB
admet-31	50	12	directly	directly	ADV
admet-31	50	13	by	by	ADP
admet-31	50	14	hplc	hplc	PROPN
admet-31	50	15	.	.	PUNCT
admet-31	51	1	subsequently	subsequently	ADV
admet-31	51	2	,	,	PUNCT
admet-31	51	3	these	these	DET
admet-31	51	4	drugs	drug	NOUN
admet-31	51	5	were	be	AUX
admet-31	51	6	studied	study	VERB
admet-31	51	7	in	in	ADP
admet-31	51	8	6	6	NUM
admet-31	51	9	–	–	SYM
admet-31	51	10	24	24	NUM
admet-31	51	11	%	%	NOUN
admet-31	51	12	w	w	PROPN
admet-31	51	13	/	/	SYM
admet-31	51	14	w	w	NOUN
admet-31	51	15	methanol	methanol	NOUN
admet-31	51	16	-	-	PUNCT
admet-31	51	17	water	water	NOUN
admet-31	51	18	mixtures	mixture	NOUN
admet-31	51	19	.	.	PUNCT
admet-31	52	1	the	the	DET
admet-31	52	2	corresponding	corresponding	ADJ
admet-31	52	3	intrinsic	intrinsic	ADJ
admet-31	52	4	solubilities	solubility	NOUN
admet-31	52	5	,	,	PUNCT
admet-31	52	6	s0	s0	PROPN
admet-31	52	7	,	,	PUNCT
admet-31	52	8	were	be	AUX
admet-31	52	9	determined	determine	VERB
admet-31	52	10	by	by	ADP
admet-31	52	11	extrapolation	extrapolation	NOUN
admet-31	52	12	of	of	ADP
admet-31	52	13	the	the	DET
admet-31	52	14	watercosolvent	watercosolvent	NOUN
admet-31	52	15	solubilities	solubility	NOUN
admet-31	52	16	to	to	ADP
admet-31	52	17	zero	zero	NUM
admet-31	52	18	cosolvent	cosolvent	NOUN
admet-31	52	19	.	.	PUNCT
admet-31	53	1	in	in	ADP
admet-31	53	2	most	most	ADJ
admet-31	53	3	cases	case	NOUN
admet-31	53	4	,	,	PUNCT
admet-31	53	5	the	the	DET
admet-31	53	6	value	value	NOUN
admet-31	53	7	of	of	ADP
admet-31	53	8	s0	s0	PROPN
admet-31	53	9	was	be	AUX
admet-31	53	10	assigned	assign	VERB
admet-31	53	11	to	to	ADP
admet-31	53	12	the	the	DET
admet-31	53	13	drug	drug	NOUN
admet-31	53	14	solubility	solubility	NOUN
admet-31	53	15	at	at	ADP
admet-31	53	16	ph	ph	PROPN
admet-31	53	17	≈	≈	PROPN
admet-31	53	18	pka	pka	PROPN
admet-31	53	19	+	+	PROPN
admet-31	53	20	2	2	NUM
admet-31	53	21	,	,	PUNCT
admet-31	53	22	where	where	SCONJ
admet-31	53	23	the	the	DET
admet-31	53	24	drug	drug	NOUN
admet-31	53	25	was	be	AUX
admet-31	53	26	expected	expect	VERB
admet-31	53	27	to	to	PART
admet-31	53	28	be	be	AUX
admet-31	53	29	predominantly	predominantly	ADV
admet-31	53	30	uncharged	uncharge	VERB
admet-31	53	31	.	.	PUNCT
admet-31	54	1	the	the	DET
admet-31	54	2	assays	assay	NOUN
admet-31	54	3	appeared	appear	VERB
admet-31	54	4	to	to	PART
admet-31	54	5	be	be	AUX
admet-31	54	6	well	well	ADV
admet-31	54	7	designed	design	VERB
admet-31	54	8	.	.	PUNCT
admet-31	55	1	however	however	ADV
admet-31	55	2	,	,	PUNCT
admet-31	55	3	it	it	PRON
admet-31	55	4	would	would	AUX
admet-31	55	5	have	have	AUX
admet-31	55	6	been	be	AUX
admet-31	55	7	helpful	helpful	ADJ
admet-31	55	8	presently	presently	ADV
admet-31	55	9	to	to	PART
admet-31	55	10	have	have	VERB
admet-31	55	11	access	access	NOUN
admet-31	55	12	to	to	ADP
admet-31	55	13	the	the	DET
admet-31	55	14	actual	actual	ADJ
admet-31	55	15	amounts	amount	NOUN
admet-31	55	16	of	of	ADP
admet-31	55	17	drug	drug	NOUN
admet-31	55	18	added	add	VERB
admet-31	55	19	per	per	ADP
admet-31	55	20	ml	ml	NOUN
admet-31	55	21	of	of	ADP
admet-31	55	22	buffer	buffer	NOUN
admet-31	55	23	in	in	ADP
admet-31	55	24	the	the	DET
admet-31	55	25	original	original	ADJ
admet-31	55	26	study	study	NOUN
admet-31	55	27	.	.	PUNCT
admet-31	56	1	in	in	ADP
admet-31	56	2	addition	addition	NOUN
admet-31	56	3	,	,	PUNCT
admet-31	56	4	it	it	PRON
admet-31	56	5	is	be	AUX
admet-31	56	6	plausible	plausible	ADJ
admet-31	56	7	that	that	SCONJ
admet-31	56	8	some	some	PRON
admet-31	56	9	of	of	ADP
admet-31	56	10	the	the	DET
admet-31	56	11	practically	practically	ADV
admet-31	56	12	insoluble	insoluble	ADJ
admet-31	56	13	drugs	drug	NOUN
admet-31	56	14	had	have	AUX
admet-31	56	15	not	not	PART
admet-31	56	16	reached	reach	VERB
admet-31	56	17	true	true	ADJ
admet-31	56	18	thermodynamic	thermodynamic	ADJ
admet-31	56	19	equilibrium	equilibrium	NOUN
admet-31	56	20	in	in	ADP
admet-31	56	21	24	24	NUM
admet-31	56	22	h.	h.	NOUN
admet-31	56	23	this	this	PRON
admet-31	56	24	could	could	AUX
admet-31	56	25	be	be	AUX
admet-31	56	26	a	a	DET
admet-31	56	27	topic	topic	NOUN
admet-31	56	28	of	of	ADP
admet-31	56	29	further	further	ADJ
admet-31	56	30	study	study	NOUN
admet-31	56	31	.	.	PUNCT
admet-31	57	1	refinement	refinement	NOUN
admet-31	57	2	of	of	ADP
admet-31	57	3	intrinsic	intrinsic	ADJ
admet-31	57	4	and	and	CCONJ
admet-31	57	5	salt	salt	NOUN
admet-31	57	6	solubility	solubility	NOUN
admet-31	57	7	and	and	CCONJ
admet-31	57	8	aggregation	aggregation	NOUN
admet-31	57	9	constants	constant	NOUN
admet-31	57	10	the	the	DET
admet-31	57	11	new	new	ADJ
admet-31	57	12	data	datum	NOUN
admet-31	57	13	analysis	analysis	NOUN
admet-31	57	14	method	method	NOUN
admet-31	57	15	uses	use	VERB
admet-31	57	16	log	log	PROPN
admet-31	57	17	s	s	NOUN
admet-31	57	18	ph	ph	NOUN
admet-31	57	19	as	as	ADP
admet-31	57	20	measured	measure	VERB
admet-31	57	21	input	input	NOUN
admet-31	57	22	data	datum	NOUN
admet-31	57	23	(	(	PUNCT
admet-31	57	24	along	along	ADP
admet-31	57	25	with	with	ADP
admet-31	57	26	the	the	DET
admet-31	57	27	standard	standard	ADJ
admet-31	57	28	deviations	deviation	NOUN
admet-31	57	29	in	in	ADP
admet-31	57	30	log	log	PROPN
admet-31	57	31	s	s	NOUN
admet-31	57	32	)	)	PUNCT
admet-31	57	33	into	into	ADP
admet-31	57	34	the	the	DET
admet-31	57	35	pdisol	pdisol	ADJ
admet-31	57	36	-	-	PUNCT
admet-31	57	37	x	x	NOUN
admet-31	57	38	computer	computer	NOUN
admet-31	57	39	program	program	NOUN
admet-31	57	40	,	,	PUNCT
admet-31	57	41	as	as	SCONJ
admet-31	57	42	described	describe	VERB
admet-31	57	43	previously	previously	ADV
admet-31	57	44	[	[	X
admet-31	57	45	11,12	11,12	NOUN
admet-31	57	46	]	]	PUNCT
admet-31	57	47	.	.	PUNCT
admet-31	58	1	solubility	solubility	NOUN
admet-31	58	2	values	value	NOUN
admet-31	58	3	from	from	ADP
admet-31	58	4	literature	literature	NOUN
admet-31	58	5	sources	source	NOUN
admet-31	58	6	are	be	AUX
admet-31	58	7	converted	convert	VERB
admet-31	58	8	to	to	ADP
admet-31	58	9	molarity	molarity	NOUN
admet-31	58	10	units	unit	NOUN
admet-31	58	11	for	for	ADP
admet-31	58	12	processing	processing	NOUN
admet-31	58	13	by	by	ADP
admet-31	58	14	the	the	DET
admet-31	58	15	program	program	NOUN
admet-31	58	16	.	.	PUNCT
admet-31	59	1	briefly	briefly	NOUN
admet-31	59	2	,	,	PUNCT
admet-31	59	3	an	an	DET
admet-31	59	4	algorithm	algorithm	NOUN
admet-31	59	5	was	be	AUX
admet-31	59	6	developed	develop	VERB
admet-31	59	7	which	which	PRON
admet-31	59	8	considers	consider	VERB
admet-31	59	9	the	the	DET
admet-31	59	10	contributions	contribution	NOUN
admet-31	59	11	of	of	ADP
admet-31	59	12	all	all	DET
admet-31	59	13	species	specie	NOUN
admet-31	59	14	present	present	ADJ
admet-31	59	15	in	in	ADP
admet-31	59	16	solution	solution	NOUN
admet-31	59	17	,	,	PUNCT
admet-31	59	18	including	include	VERB
admet-31	59	19	all	all	DET
admet-31	59	20	components	component	NOUN
admet-31	59	21	of	of	ADP
admet-31	59	22	buffers	buffer	NOUN
admet-31	59	23	or	or	CCONJ
admet-31	59	24	mixtures	mixture	NOUN
admet-31	59	25	thereof	thereof	ADV
admet-31	59	26	.	.	PUNCT
admet-31	60	1	the	the	DET
admet-31	60	2	approach	approach	NOUN
admet-31	60	3	does	do	AUX
admet-31	60	4	not	not	PART
admet-31	60	5	depend	depend	VERB
admet-31	60	6	on	on	ADP
admet-31	60	7	any	any	DET
admet-31	60	8	explicitly	explicitly	ADV
admet-31	60	9	derived	derive	VERB
admet-31	60	10	extensions	extension	NOUN
admet-31	60	11	of	of	ADP
admet-31	60	12	the	the	DET
admet-31	60	13	henderson	henderson	PROPN
admet-31	60	14	-	-	PUNCT
admet-31	60	15	hasselbalch	hasselbalch	PROPN
admet-31	60	16	equations	equation	NOUN
admet-31	60	17	[	[	X
admet-31	60	18	1	1	NUM
admet-31	60	19	]	]	PUNCT
admet-31	60	20	.	.	PUNCT
admet-31	61	1	the	the	DET
admet-31	61	2	uniqueness	uniqueness	NOUN
admet-31	61	3	of	of	ADP
admet-31	61	4	the	the	DET
admet-31	61	5	computational	computational	ADJ
admet-31	61	6	algorithm	algorithm	NOUN
admet-31	61	7	is	be	AUX
admet-31	61	8	that	that	SCONJ
admet-31	61	9	it	it	PRON
admet-31	61	10	derives	derive	VERB
admet-31	61	11	its	its	PRON
admet-31	61	12	own	own	ADJ
admet-31	61	13	implicit	implicit	ADJ
admet-31	61	14	equations	equation	NOUN
admet-31	61	15	internally	internally	ADV
admet-31	61	16	,	,	PUNCT
admet-31	61	17	given	give	VERB
admet-31	61	18	any	any	DET
admet-31	61	19	practical	practical	ADJ
admet-31	61	20	number	number	NOUN
admet-31	61	21	of	of	ADP
admet-31	61	22	equilibria	equilibrium	NOUN
admet-31	61	23	and	and	CCONJ
admet-31	61	24	estimated	estimated	ADJ
admet-31	61	25	constants	constant	NOUN
admet-31	61	26	,	,	PUNCT
admet-31	61	27	which	which	PRON
admet-31	61	28	are	be	AUX
admet-31	61	29	subsequently	subsequently	ADV
admet-31	61	30	refined	refine	VERB
admet-31	61	31	by	by	ADP
admet-31	61	32	weighted	weight	VERB
admet-31	61	33	nonlinear	nonlinear	ADJ
admet-31	61	34	least	least	ADJ
admet-31	61	35	-	-	PUNCT
admet-31	61	36	squares	square	NOUN
admet-31	61	37	regression	regression	NOUN
admet-31	61	38	.	.	PUNCT
admet-31	62	1	drug	drug	NOUN
admet-31	62	2	-	-	PUNCT
admet-31	62	3	salt	salt	NOUN
admet-31	62	4	precipitates	precipitate	NOUN
admet-31	62	5	,	,	PUNCT
admet-31	62	6	-aggregates	-aggregate	NOUN
admet-31	62	7	,	,	PUNCT
admet-31	62	8	-complexes	-complexe	NOUN
admet-31	62	9	,	,	PUNCT
admet-31	62	10	bile	bile	NOUN
admet-31	62	11	salt	salt	NOUN
admet-31	62	12	and	and	CCONJ
admet-31	62	13	-surfactant	-surfactant	ADJ
admet-31	62	14	species	specie	NOUN
admet-31	62	15	can	can	AUX
admet-31	62	16	be	be	AUX
admet-31	62	17	modeled	model	VERB
admet-31	62	18	[	[	PUNCT
admet-31	62	19	1,5	1,5	NUM
admet-31	62	20	]	]	PUNCT
admet-31	62	21	.	.	PUNCT
admet-31	63	1	the	the	DET
admet-31	63	2	presence	presence	NOUN
admet-31	63	3	of	of	ADP
admet-31	63	4	specific	specific	ADJ
admet-31	63	5	buffer	buffer	NOUN
admet-31	63	6	-	-	PUNCT
admet-31	63	7	drug	drug	NOUN
admet-31	63	8	formed	form	VERB
admet-31	63	9	species	specie	NOUN
admet-31	63	10	can	can	AUX
admet-31	63	11	be	be	AUX
admet-31	63	12	tested	test	VERB
admet-31	63	13	.	.	PUNCT
admet-31	64	1	the	the	DET
admet-31	64	2	computer	computer	NOUN
admet-31	64	3	program	program	NOUN
admet-31	64	4	calculates	calculate	VERB
admet-31	64	5	the	the	DET
admet-31	64	6	distribution	distribution	NOUN
admet-31	64	7	of	of	ADP
admet-31	64	8	species	specie	NOUN
admet-31	64	9	corresponding	correspond	VERB
admet-31	64	10	to	to	ADP
admet-31	64	11	a	a	DET
admet-31	64	12	sequence	sequence	NOUN
admet-31	64	13	of	of	ADP
admet-31	64	14	additions	addition	NOUN
admet-31	64	15	of	of	ADP
admet-31	64	16	standardized	standardized	ADJ
admet-31	64	17	strong	strong	ADJ
admet-31	64	18	-	-	PUNCT
admet-31	64	19	acid	acid	NOUN
admet-31	64	20	titrant	titrant	NOUN
admet-31	64	21	hcl	hcl	PROPN
admet-31	64	22	(	(	PUNCT
admet-31	64	23	or	or	CCONJ
admet-31	64	24	weak	weak	ADJ
admet-31	64	25	-	-	PUNCT
admet-31	64	26	acid	acid	ADJ
admet-31	64	27	titrants	titrant	NOUN
admet-31	64	28	,	,	PUNCT
admet-31	64	29	e.g.	e.g.	ADV
admet-31	64	30	,	,	PUNCT
admet-31	64	31	h3po4	h3po4	NOUN
admet-31	64	32	)	)	PUNCT
admet-31	64	33	to	to	PART
admet-31	64	34	simulate	simulate	VERB
admet-31	64	35	the	the	DET
admet-31	64	36	speciation	speciation	NOUN
admet-31	64	37	in	in	ADP
admet-31	64	38	the	the	DET
admet-31	64	39	suspension	suspension	NOUN
admet-31	64	40	down	down	ADP
admet-31	64	41	to	to	ADP
admet-31	64	42	ph	ph	PROPN
admet-31	64	43	~	~	PUNCT
admet-31	64	44	0	0	X
admet-31	64	45	.	.	PUNCT
admet-31	65	1	subsequently	subsequently	ADV
admet-31	65	2	,	,	PUNCT
admet-31	65	3	a	a	DET
admet-31	65	4	sequence	sequence	NOUN
admet-31	65	5	of	of	ADP
admet-31	65	6	perturbations	perturbation	NOUN
admet-31	65	7	with	with	ADP
admet-31	65	8	standardized	standardized	ADJ
admet-31	65	9	naoh	naoh	NOUN
admet-31	65	10	(	(	PUNCT
admet-31	65	11	or	or	CCONJ
admet-31	65	12	,	,	PUNCT
admet-31	65	13	e.g.	e.g.	ADV
admet-31	65	14	,	,	PUNCT
admet-31	65	15	koh	koh	PROPN
admet-31	65	16	)	)	PUNCT
admet-31	65	17	is	be	AUX
admet-31	65	18	simulated	simulate	VERB
admet-31	65	19	,	,	PUNCT
admet-31	65	20	and	and	CCONJ
admet-31	65	21	solubility	solubility	NOUN
admet-31	65	22	calculated	calculate	VERB
admet-31	65	23	at	at	ADP
admet-31	65	24	each	each	DET
admet-31	65	25	point	point	NOUN
admet-31	65	26	(	(	PUNCT
admet-31	65	27	in	in	ADP
admet-31	65	28	ph	ph	ADJ
admet-31	65	29	steps	step	NOUN
admet-31	65	30	of	of	ADP
admet-31	65	31	0.005	0.005	NUM
admet-31	65	32	-	-	PUNCT
admet-31	65	33	0.2	0.2	NUM
admet-31	65	34	)	)	PUNCT
admet-31	65	35	,	,	PUNCT
admet-31	65	36	up	up	ADP
admet-31	65	37	to	to	ADP
admet-31	65	38	ph	ph	PROPN
admet-31	65	39	~	~	PUNCT
admet-31	65	40	13	13	NUM
admet-31	65	41	.	.	PUNCT
admet-31	66	1	the	the	DET
admet-31	66	2	ionic	ionic	ADJ
admet-31	66	3	strength	strength	NOUN
admet-31	66	4	is	be	AUX
admet-31	66	5	rigorously	rigorously	ADV
admet-31	66	6	calculated	calculate	VERB
admet-31	66	7	at	at	ADP
admet-31	66	8	each	each	DET
admet-31	66	9	step	step	NOUN
admet-31	66	10	,	,	PUNCT
admet-31	66	11	and	and	CCONJ
admet-31	66	12	pka	pka	PROPN
admet-31	66	13	values	value	NOUN
admet-31	66	14	(	(	PUNCT
admet-31	66	15	as	as	ADV
admet-31	66	16	well	well	ADV
admet-31	66	17	as	as	ADP
admet-31	66	18	solubility	solubility	NOUN
admet-31	66	19	products	product	NOUN
admet-31	66	20	,	,	PUNCT
admet-31	66	21	aggregation	aggregation	NOUN
admet-31	66	22	constants	constant	NOUN
admet-31	66	23	)	)	PUNCT
admet-31	66	24	are	be	AUX
admet-31	66	25	accordingly	accordingly	ADV
admet-31	66	26	adjusted	adjust	VERB
admet-31	66	27	[	[	PUNCT
admet-31	66	28	11	11	NUM
admet-31	66	29	]	]	PUNCT
admet-31	66	30	.	.	PUNCT
admet-31	67	1	at	at	ADP
admet-31	67	2	the	the	DET
admet-31	67	3	end	end	NOUN
admet-31	67	4	of	of	ADP
admet-31	67	5	the	the	DET
admet-31	67	6	speciation	speciation	NOUN
admet-31	67	7	simulation	simulation	NOUN
admet-31	67	8	,	,	PUNCT
admet-31	67	9	the	the	DET
admet-31	67	10	calculated	calculate	VERB
admet-31	67	11	log	log	NOUN
admet-31	67	12	s	s	PART
admet-31	67	13	vs.	vs.	X
admet-31	67	14	ph	ph	NOUN
admet-31	67	15	curve	curve	NOUN
admet-31	67	16	is	be	AUX
admet-31	67	17	compared	compare	VERB
admet-31	67	18	to	to	ADP
admet-31	67	19	actual	actual	ADJ
admet-31	67	20	measured	measure	VERB
admet-31	67	21	log	log	NOUN
admet-31	67	22	s	s	PROPN
admet-31	67	23	vs.	vs.	X
admet-31	67	24	ph	ph	PROPN
admet-31	67	25	.	.	PUNCT
admet-31	68	1	a	a	DET
admet-31	68	2	log	log	NOUN
admet-31	68	3	s	s	NOUN
admet-31	68	4	-	-	PUNCT
admet-31	68	5	weighted	weight	VERB
admet-31	68	6	nonlinear	nonlinear	ADJ
admet-31	68	7	least	least	ADJ
admet-31	68	8	squares	square	NOUN
admet-31	68	9	procedure	procedure	NOUN
admet-31	68	10	refines	refine	VERB
admet-31	68	11	the	the	DET
admet-31	68	12	proposed	propose	VERB
admet-31	68	13	equilibrium	equilibrium	NOUN
admet-31	68	14	model	model	NOUN
admet-31	68	15	,	,	PUNCT
admet-31	68	16	using	use	VERB
admet-31	68	17	analytical	analytical	ADJ
admet-31	68	18	expressions	expression	NOUN
admet-31	68	19	for	for	ADP
admet-31	68	20	the	the	DET
admet-31	68	21	differential	differential	ADJ
admet-31	68	22	equations	equation	NOUN
admet-31	68	23	.	.	PUNCT
admet-31	69	1	the	the	DET
admet-31	69	2	process	process	NOUN
admet-31	69	3	is	be	AUX
admet-31	69	4	repeated	repeat	VERB
admet-31	69	5	until	until	SCONJ
admet-31	69	6	the	the	DET
admet-31	69	7	differences	difference	NOUN
admet-31	69	8	between	between	ADP
admet-31	69	9	calculated	calculate	VERB
admet-31	69	10	and	and	CCONJ
admet-31	69	11	measured	measure	VERB
admet-31	69	12	log	log	NOUN
admet-31	69	13	s	s	PART
admet-31	69	14	values	value	NOUN
admet-31	69	15	reach	reach	VERB
admet-31	69	16	a	a	DET
admet-31	69	17	minimum	minimum	NOUN
admet-31	69	18	,	,	PUNCT
admet-31	69	19	as	as	SCONJ
admet-31	69	20	described	describe	VERB
admet-31	69	21	elsewhere	elsewhere	ADV
admet-31	69	22	in	in	ADP
admet-31	69	23	detail	detail	NOUN
admet-31	69	24	[	[	X
admet-31	69	25	11	11	NUM
admet-31	69	26	]	]	PUNCT
admet-31	69	27	.	.	PUNCT
admet-31	70	1	the	the	DET
admet-31	70	2	analysis	analysis	NOUN
admet-31	70	3	of	of	ADP
admet-31	70	4	the	the	DET
admet-31	70	5	bergström	bergström	NOUN
admet-31	70	6	log	log	NOUN
admet-31	70	7	s	s	PART
admet-31	70	8	ph	ph	NOUN
admet-31	70	9	data	datum	NOUN
admet-31	70	10	tested	test	VERB
admet-31	70	11	for	for	ADP
admet-31	70	12	the	the	DET
admet-31	70	13	presence	presence	NOUN
admet-31	70	14	of	of	ADP
admet-31	70	15	solid	solid	ADJ
admet-31	70	16	species	specie	NOUN
admet-31	70	17	b(s	b(	NOUN
admet-31	70	18	)	)	PUNCT
admet-31	70	19	,	,	PUNCT
admet-31	70	20	bh∙cl(s	bh∙cl(s	ADJ
admet-31	70	21	)	)	PUNCT
admet-31	70	22	,	,	PUNCT
admet-31	70	23	bhb∙cl(s	bhb∙cl(s	PROPN
admet-31	70	24	)	)	PUNCT
admet-31	70	25	,	,	PUNCT
admet-31	70	26	bh∙h2po4(s	bh∙h2po4(s	PROPN
admet-31	70	27	)	)	PUNCT
admet-31	70	28	,	,	PUNCT
admet-31	70	29	(	(	PUNCT
admet-31	70	30	bh)2∙hpo4(s	bh)2∙hpo4(s	NOUN
admet-31	70	31	)	)	PUNCT
admet-31	70	32	,	,	PUNCT
admet-31	70	33	bhb∙h2po4(s	bhb∙h2po4(s	NOUN
admet-31	70	34	)	)	PUNCT
admet-31	70	35	,	,	PUNCT
admet-31	70	36	(	(	PUNCT
admet-31	70	37	bhb)2∙hpo4(s	bhb)2∙hpo4(s	NOUN
admet-31	70	38	)	)	PUNCT
admet-31	70	39	,	,	PUNCT
admet-31	70	40	(	(	PUNCT
admet-31	70	41	bh)3∙h2po4∙hpo4(s	bh)3∙h2po4∙hpo4(s	NOUN
admet-31	70	42	)	)	PUNCT
admet-31	70	43	,	,	PUNCT
admet-31	70	44	as	as	ADV
admet-31	70	45	well	well	ADV
admet-31	70	46	as	as	ADP
admet-31	70	47	water	water	NOUN
admet-31	70	48	soluble	soluble	ADJ
admet-31	70	49	cationic	cationic	ADJ
admet-31	70	50	aggregates	aggregate	NOUN
admet-31	70	51	(	(	PUNCT
admet-31	70	52	bh)n	bh)n	PROPN
admet-31	70	53	and	and	CCONJ
admet-31	70	54	(	(	PUNCT
admet-31	70	55	bhb)n	bhb)n	PROPN
admet-31	70	56	,	,	PUNCT
admet-31	70	57	n	n	NOUN
admet-31	70	58	=	=	SYM
admet-31	70	59	1	1	NUM
admet-31	70	60	-	-	SYM
admet-31	70	61	6	6	NUM
admet-31	70	62	,	,	PUNCT
admet-31	70	63	and	and	CCONJ
admet-31	70	64	the	the	DET
admet-31	70	65	uncharged	uncharged	ADJ
admet-31	70	66	aggregate	aggregate	ADJ
admet-31	70	67	b2	b2	NOUN
admet-31	70	68	.	.	PUNCT
admet-31	71	1	up	up	ADP
admet-31	71	2	to	to	PART
admet-31	71	3	three	three	NUM
admet-31	71	4	different	different	ADJ
admet-31	71	5	solids	solid	NOUN
admet-31	71	6	could	could	AUX
admet-31	71	7	be	be	AUX
admet-31	71	8	tested	test	VERB
admet-31	71	9	in	in	ADP
admet-31	71	10	a	a	DET
admet-31	71	11	single	single	ADJ
admet-31	71	12	calculation	calculation	NOUN
admet-31	71	13	.	.	PUNCT
admet-31	72	1	the	the	DET
admet-31	72	2	presence	presence	NOUN
admet-31	72	3	of	of	ADP
admet-31	72	4	particular	particular	ADJ
admet-31	72	5	species	specie	NOUN
admet-31	72	6	was	be	AUX
admet-31	72	7	suggested	suggest	VERB
admet-31	72	8	by	by	ADP
admet-31	72	9	the	the	DET
admet-31	72	10	slope	slope	NOUN
admet-31	72	11	characteristics	characteristic	NOUN
admet-31	72	12	of	of	ADP
admet-31	72	13	the	the	DET
admet-31	72	14	log	log	NOUN
admet-31	72	15	s	s	NOUN
admet-31	72	16	ph	ph	NOUN
admet-31	72	17	curve	curve	NOUN
admet-31	72	18	[	[	X
admet-31	72	19	1,5,7	1,5,7	NUM
admet-31	72	20	-	-	SYM
admet-31	72	21	11	11	NUM
admet-31	72	22	]	]	PUNCT
admet-31	72	23	.	.	PUNCT
admet-31	73	1	avdeef	avdeef	PROPN
admet-31	73	2	admet	admet	PROPN
admet-31	73	3	&	&	CCONJ
admet-31	73	4	dmpk	dmpk	PROPN
admet-31	73	5	2(1	2(1	NUM
admet-31	73	6	)	)	PUNCT
admet-31	73	7	(	(	PUNCT
admet-31	73	8	2014	2014	NUM
admet-31	73	9	)	)	PUNCT
admet-31	73	10	43	43	NUM
admet-31	73	11	-	-	SYM
admet-31	73	12	55	55	NUM
admet-31	73	13	46	46	NUM
admet-31	73	14	results	result	NOUN
admet-31	73	15	and	and	CCONJ
admet-31	73	16	discussion	discussion	NOUN
admet-31	73	17	based	base	VERB
admet-31	73	18	on	on	ADP
admet-31	73	19	the	the	DET
admet-31	73	20	results	result	NOUN
admet-31	73	21	of	of	ADP
admet-31	73	22	the	the	DET
admet-31	73	23	analysis	analysis	NOUN
admet-31	73	24	,	,	PUNCT
admet-31	73	25	the	the	DET
admet-31	73	26	25	25	NUM
admet-31	73	27	drugs	drug	NOUN
admet-31	73	28	were	be	AUX
admet-31	73	29	divided	divide	VERB
admet-31	73	30	into	into	ADP
admet-31	73	31	six	six	NUM
admet-31	73	32	groups	group	NOUN
admet-31	73	33	,	,	PUNCT
admet-31	73	34	according	accord	VERB
admet-31	73	35	to	to	ADP
admet-31	73	36	the	the	DET
admet-31	73	37	type	type	NOUN
admet-31	73	38	of	of	ADP
admet-31	73	39	deviations	deviation	NOUN
admet-31	73	40	from	from	ADP
admet-31	73	41	the	the	DET
admet-31	73	42	henderson	henderson	PROPN
admet-31	73	43	-	-	PUNCT
admet-31	73	44	hasselbalch	hasselbalch	PROPN
admet-31	73	45	equation	equation	NOUN
admet-31	73	46	in	in	ADP
admet-31	73	47	the	the	DET
admet-31	73	48	non	non	ADJ
admet-31	73	49	-	-	ADJ
admet-31	73	50	salt	salt	ADJ
admet-31	73	51	regions	region	NOUN
admet-31	73	52	(	(	PUNCT
admet-31	73	53	ph	ph	X
admet-31	73	54	>	>	X
admet-31	73	55	pka	pka	PROPN
admet-31	73	56	gibbs	gibbs	PROPN
admet-31	74	1	[	[	X
admet-31	74	2	14,15	14,15	NUM
admet-31	74	3	]	]	PUNCT
admet-31	74	4	)	)	PUNCT
admet-31	74	5	of	of	ADP
admet-31	74	6	the	the	DET
admet-31	74	7	log	log	NOUN
admet-31	74	8	s	s	PART
admet-31	74	9	–	–	PUNCT
admet-31	74	10	ph	ph	ADJ
admet-31	74	11	curves	curve	NOUN
admet-31	74	12	,	,	PUNCT
admet-31	74	13	as	as	SCONJ
admet-31	74	14	discussed	discuss	VERB
admet-31	74	15	at	at	ADP
admet-31	74	16	length	length	NOUN
admet-31	74	17	by	by	ADP
admet-31	74	18	avdeef	avdeef	NOUN
admet-31	74	19	[	[	X
admet-31	74	20	1	1	NUM
admet-31	74	21	]	]	PUNCT
admet-31	74	22	.	.	PUNCT
admet-31	75	1			PRON
admet-31	75	2	case	case	NOUN
admet-31	75	3	0	0	PUNCT
admet-31	75	4	(	(	PUNCT
admet-31	75	5	24	24	NUM
admet-31	75	6	%	%	NOUN
admet-31	75	7	of	of	ADP
admet-31	75	8	all	all	DET
admet-31	75	9	drugs	drug	NOUN
admet-31	75	10	):	):	PUNCT
admet-31	75	11	follow	follow	PROPN
admet-31	75	12	henderson	henderson	PROPN
admet-31	75	13	-	-	PUNCT
admet-31	75	14	hasselbalch	hasselbalch	PROPN
admet-31	75	15	equation	equation	NOUN
admet-31	75	16	,	,	PUNCT
admet-31	75	17	and	and	CCONJ
admet-31	75	18	apparent	apparent	ADJ
admet-31	75	19	s0	s0	NOUN
admet-31	75	20	=	=	PUNCT
admet-31	75	21	true	true	ADJ
admet-31	75	22	s0	s0	PROPN
admet-31	75	23	.	.	PUNCT
admet-31	76	1			PRON
admet-31	76	2	case	case	NOUN
admet-31	76	3	1b	1b	NUM
admet-31	76	4	(	(	PUNCT
admet-31	76	5	24	24	NUM
admet-31	76	6	%	%	NOUN
admet-31	76	7	):	):	PUNCT
admet-31	76	8	apparent	apparent	ADJ
admet-31	76	9	pka	pka	PROPN
admet-31	76	10	<	<	X
admet-31	76	11	true	true	ADJ
admet-31	76	12	pka	pka	PROPN
admet-31	76	13	and	and	CCONJ
admet-31	76	14	apparent	apparent	ADJ
admet-31	76	15	s0	s0	PROPN
admet-31	76	16	>	>	PUNCT
admet-31	76	17	true	true	ADJ
admet-31	76	18	s0	s0	PROPN
admet-31	76	19	,	,	PUNCT
admet-31	76	20	which	which	PRON
admet-31	76	21	is	be	AUX
admet-31	76	22	consistent	consistent	ADJ
admet-31	76	23	with	with	ADP
admet-31	76	24	the	the	DET
admet-31	76	25	formation	formation	NOUN
admet-31	76	26	of	of	ADP
admet-31	76	27	water	water	NOUN
admet-31	76	28	-	-	PUNCT
admet-31	76	29	soluble	soluble	ADJ
admet-31	76	30	uncharged	uncharged	ADJ
admet-31	76	31	aggregates	aggregate	NOUN
admet-31	76	32	;	;	PUNCT
admet-31	76	33	degree	degree	NOUN
admet-31	76	34	of	of	ADP
admet-31	76	35	aggregation	aggregation	NOUN
admet-31	76	36	can	can	AUX
admet-31	76	37	not	not	PART
admet-31	76	38	be	be	AUX
admet-31	76	39	determined	determine	VERB
admet-31	76	40	from	from	ADP
admet-31	76	41	ph	ph	ADJ
admet-31	76	42	-	-	NOUN
admet-31	76	43	dependence	dependence	NOUN
admet-31	76	44	.	.	PUNCT
admet-31	77	1			PRON
admet-31	77	2	case	case	NOUN
admet-31	77	3	2b	2b	NUM
admet-31	77	4	(	(	PUNCT
admet-31	77	5	16	16	NUM
admet-31	77	6	%	%	NOUN
admet-31	77	7	):	):	PUNCT
admet-31	77	8	diagonal	diagonal	ADJ
admet-31	77	9	region	region	NOUN
admet-31	77	10	of	of	ADP
admet-31	77	11	the	the	DET
admet-31	77	12	log	log	NOUN
admet-31	77	13	s	s	PART
admet-31	77	14	–	–	PUNCT
admet-31	77	15	ph	ph	ADJ
admet-31	77	16	profile	profile	NOUN
admet-31	77	17	has	have	VERB
admet-31	77	18	non	non	ADJ
admet-31	77	19	-	-	ADJ
admet-31	77	20	unit	unit	ADJ
admet-31	77	21	slope	slope	NOUN
admet-31	77	22	,	,	PUNCT
admet-31	77	23	indicative	indicative	ADJ
admet-31	77	24	of	of	ADP
admet-31	77	25	cationic	cationic	ADJ
admet-31	77	26	aggregates	aggregate	NOUN
admet-31	77	27	,	,	PUNCT
admet-31	77	28	where	where	SCONJ
admet-31	77	29	the	the	DET
admet-31	77	30	average	average	ADJ
admet-31	77	31	degree	degree	NOUN
admet-31	77	32	of	of	ADP
admet-31	77	33	aggregation	aggregation	NOUN
admet-31	77	34	defined	define	VERB
admet-31	77	35	by	by	ADP
admet-31	77	36	the	the	DET
admet-31	77	37	value	value	NOUN
admet-31	77	38	of	of	ADP
admet-31	77	39	the	the	DET
admet-31	77	40	slope	slope	NOUN
admet-31	77	41	;	;	PUNCT
admet-31	77	42	apparent	apparent	ADJ
admet-31	77	43	s0	s0	NOUN
admet-31	77	44	=	=	PUNCT
admet-31	77	45	true	true	ADJ
admet-31	77	46	s0	s0	PROPN
admet-31	77	47	.	.	PUNCT
admet-31	78	1			PRON
admet-31	78	2	case	case	NOUN
admet-31	78	3	3b	3b	NUM
admet-31	78	4	(	(	PUNCT
admet-31	78	5	16	16	NUM
admet-31	78	6	%	%	NOUN
admet-31	78	7	):	):	PUNCT
admet-31	78	8	diagonal	diagonal	ADJ
admet-31	78	9	region	region	NOUN
admet-31	78	10	of	of	ADP
admet-31	78	11	the	the	DET
admet-31	78	12	log	log	NOUN
admet-31	78	13	s	s	PART
admet-31	78	14	–	–	PUNCT
admet-31	78	15	ph	ph	ADJ
admet-31	78	16	profile	profile	NOUN
admet-31	78	17	(	(	PUNCT
admet-31	78	18	slope	slope	NOUN
admet-31	78	19	=	=	SYM
admet-31	78	20	-1	-1	PRON
admet-31	78	21	)	)	PUNCT
admet-31	78	22	shifted	shift	VERB
admet-31	78	23	to	to	ADP
admet-31	78	24	higher	high	ADJ
admet-31	78	25	ph	ph	NOUN
admet-31	78	26	than	than	SCONJ
admet-31	78	27	predicted	predict	VERB
admet-31	78	28	by	by	ADP
admet-31	78	29	henderson	henderson	PROPN
admet-31	78	30	-	-	PUNCT
admet-31	78	31	hasselbalch	hasselbalch	PROPN
admet-31	78	32	equation	equation	NOUN
admet-31	78	33	(	(	PUNCT
admet-31	78	34	i.e.	i.e.	X
admet-31	78	35	,	,	PUNCT
admet-31	78	36	apparent	apparent	ADJ
admet-31	78	37	pka	pka	PROPN
admet-31	78	38	>	>	X
admet-31	78	39	true	true	ADJ
admet-31	78	40	pka	pka	PROPN
admet-31	78	41	)	)	PUNCT
admet-31	78	42	,	,	PUNCT
admet-31	78	43	indicative	indicative	ADJ
admet-31	78	44	of	of	ADP
admet-31	78	45	mixed	mixed	ADJ
admet-31	78	46	-	-	PUNCT
admet-31	78	47	charge	charge	NOUN
admet-31	78	48	dimeric	dimeric	ADJ
admet-31	78	49	aggregates	aggregate	NOUN
admet-31	78	50	,	,	PUNCT
admet-31	78	51	bhb	bhb	ADJ
admet-31	78	52	+	+	CCONJ
admet-31	78	53	,	,	PUNCT
admet-31	78	54	or	or	CCONJ
admet-31	78	55	higher	high	ADJ
admet-31	78	56	order	order	NOUN
admet-31	78	57	oligomers	oligomer	NOUN
admet-31	78	58	of	of	ADP
admet-31	78	59	the	the	DET
admet-31	78	60	same	same	ADJ
admet-31	78	61	stoichiometric	stoichiometric	NOUN
admet-31	78	62	ratio	ratio	NOUN
admet-31	78	63	;	;	PUNCT
admet-31	78	64	apparent	apparent	ADJ
admet-31	78	65	s0	s0	NOUN
admet-31	78	66	=	=	PUNCT
admet-31	78	67	true	true	ADJ
admet-31	78	68	s0	s0	PROPN
admet-31	78	69	.	.	PUNCT
admet-31	79	1			NOUN
admet-31	79	2	two	two	NUM
admet-31	79	3	group	group	NOUN
admet-31	79	4	of	of	ADP
admet-31	79	5	compounds	compound	NOUN
admet-31	79	6	showed	show	VERB
admet-31	79	7	combined	combined	ADJ
admet-31	79	8	case	case	NOUN
admet-31	79	9	1b+2b	1b+2b	NUM
admet-31	79	10	(	(	PUNCT
admet-31	79	11	8	8	NUM
admet-31	79	12	%	%	NOUN
admet-31	79	13	)	)	PUNCT
admet-31	79	14	and	and	CCONJ
admet-31	79	15	case	case	NOUN
admet-31	79	16	2b+3b	2b+3b	NUM
admet-31	79	17	(	(	PUNCT
admet-31	79	18	12	12	NUM
admet-31	79	19	%	%	NOUN
admet-31	79	20	)	)	PUNCT
admet-31	79	21	.	.	PUNCT
admet-31	80	1	the	the	DET
admet-31	80	2	results	result	NOUN
admet-31	80	3	of	of	ADP
admet-31	80	4	the	the	DET
admet-31	80	5	analysis	analysis	NOUN
admet-31	80	6	of	of	ADP
admet-31	80	7	the	the	DET
admet-31	80	8	bergström	bergström	NOUN
admet-31	80	9	et	et	PROPN
admet-31	80	10	al	al	PROPN
admet-31	80	11	.	.	PROPN
admet-31	80	12	data	datum	NOUN
admet-31	80	13	are	be	AUX
admet-31	80	14	summarized	summarize	VERB
admet-31	80	15	in	in	ADP
admet-31	80	16	table	table	NOUN
admet-31	80	17	1	1	NUM
admet-31	80	18	,	,	PUNCT
admet-31	80	19	with	with	ADP
admet-31	80	20	all	all	DET
admet-31	80	21	constants	constant	NOUN
admet-31	80	22	presented	present	VERB
admet-31	80	23	in	in	ADP
admet-31	80	24	molarity	molarity	NOUN
admet-31	80	25	or	or	CCONJ
admet-31	80	26	molarity	molarity	NOUN
admet-31	80	27	related	relate	VERB
admet-31	80	28	units	unit	NOUN
admet-31	80	29	.	.	PUNCT
admet-31	81	1	figure	figure	NOUN
admet-31	81	2	1	1	NUM
admet-31	81	3	compares	compare	VERB
admet-31	81	4	intrinsic	intrinsic	ADJ
admet-31	81	5	solubility	solubility	NOUN
admet-31	81	6	,	,	PUNCT
admet-31	81	7	ps0	ps0	PROPN
admet-31	81	8	(	(	PUNCT
admet-31	81	9	-log10	-log10	X
admet-31	81	10	s0	s0	PROPN
admet-31	81	11	)	)	PUNCT
admet-31	81	12	,	,	PUNCT
admet-31	81	13	of	of	ADP
admet-31	81	14	the	the	DET
admet-31	81	15	compounds	compound	NOUN
admet-31	81	16	determined	determine	VERB
admet-31	81	17	in	in	ADP
admet-31	81	18	this	this	DET
admet-31	81	19	study	study	NOUN
admet-31	81	20	to	to	ADP
admet-31	81	21	that	that	PRON
admet-31	81	22	reported	report	VERB
admet-31	81	23	by	by	ADP
admet-31	81	24	bergström	bergström	NOUN
admet-31	81	25	et	et	PROPN
admet-31	81	26	al	al	PROPN
admet-31	81	27	.	.	PUNCT
admet-31	82	1	[	[	X
admet-31	82	2	13	13	NUM
admet-31	82	3	]	]	PUNCT
admet-31	82	4	.	.	PUNCT
admet-31	83	1	amiodarone	amiodarone	NOUN
admet-31	83	2	is	be	AUX
admet-31	83	3	not	not	PART
admet-31	83	4	shown	show	VERB
admet-31	83	5	in	in	ADP
admet-31	83	6	figure	figure	NOUN
admet-31	83	7	1	1	NUM
admet-31	83	8	,	,	PUNCT
admet-31	83	9	since	since	SCONJ
admet-31	83	10	the	the	DET
admet-31	83	11	previously	previously	ADV
admet-31	83	12	reported	report	VERB
admet-31	83	13	value	value	NOUN
admet-31	83	14	was	be	AUX
admet-31	83	15	stated	state	VERB
admet-31	83	16	conditionally	conditionally	ADV
admet-31	83	17	(	(	PUNCT
admet-31	83	18	table	table	NOUN
admet-31	83	19	1	1	NUM
admet-31	83	20	)	)	PUNCT
admet-31	83	21	.	.	PUNCT
admet-31	84	1	the	the	DET
admet-31	84	2	eight	eight	NUM
admet-31	84	3	compounds	compound	NOUN
admet-31	84	4	in	in	ADP
admet-31	84	5	figure	figure	NOUN
admet-31	84	6	1	1	NUM
admet-31	84	7	represented	represent	VERB
admet-31	84	8	as	as	ADP
admet-31	84	9	checkered	checker	VERB
admet-31	84	10	circles	circle	NOUN
admet-31	84	11	are	be	AUX
admet-31	84	12	all	all	PRON
admet-31	84	13	examples	example	NOUN
admet-31	84	14	of	of	ADP
admet-31	84	15	case	case	NOUN
admet-31	84	16	1b	1b	NUM
admet-31	84	17	,	,	PUNCT
admet-31	84	18	and	and	CCONJ
admet-31	84	19	showed	show	VERB
admet-31	84	20	the	the	DET
admet-31	84	21	largest	large	ADJ
admet-31	84	22	variances	variance	NOUN
admet-31	84	23	from	from	ADP
admet-31	84	24	the	the	DET
admet-31	84	25	reported	report	VERB
admet-31	84	26	intrinsic	intrinsic	ADJ
admet-31	84	27	solubility	solubility	NOUN
admet-31	84	28	values	value	NOUN
admet-31	84	29	.	.	PUNCT
admet-31	85	1	on	on	ADP
admet-31	85	2	the	the	DET
admet-31	85	3	other	other	ADJ
admet-31	85	4	hand	hand	NOUN
admet-31	85	5	,	,	PUNCT
admet-31	85	6	the	the	DET
admet-31	85	7	agreement	agreement	NOUN
admet-31	85	8	between	between	ADP
admet-31	85	9	the	the	DET
admet-31	85	10	filled	fill	VERB
admet-31	85	11	circle	circle	NOUN
admet-31	85	12	compounds	compound	NOUN
admet-31	85	13	(	(	PUNCT
admet-31	85	14	corresponding	correspond	VERB
admet-31	85	15	to	to	ADP
admet-31	85	16	other	other	ADJ
admet-31	85	17	cases	case	NOUN
admet-31	85	18	)	)	PUNCT
admet-31	85	19	determined	determine	VERB
admet-31	85	20	here	here	ADV
admet-31	85	21	and	and	CCONJ
admet-31	85	22	reported	report	VERB
admet-31	85	23	previously	previously	ADV
admet-31	85	24	is	be	AUX
admet-31	85	25	very	very	ADV
admet-31	85	26	good	good	ADJ
admet-31	85	27	:	:	PUNCT
admet-31	85	28	ps0	ps0	VERB
admet-31	85	29	bergström	bergström	NOUN
admet-31	85	30	=	=	NOUN
admet-31	85	31	0.02	0.02	NUM
admet-31	85	32	+	+	CCONJ
admet-31	85	33	1.007	1.007	NUM
admet-31	85	34	ps0	ps0	ADJ
admet-31	85	35	pdisol	pdisol	ADJ
admet-31	85	36	-	-	PUNCT
admet-31	85	37	x	x	NOUN
admet-31	85	38	,	,	PUNCT
admet-31	85	39	r2=0.99	r2=0.99	NOUN
admet-31	85	40	,	,	PUNCT
admet-31	85	41	s=0.17	s=0.17	PROPN
admet-31	85	42	,	,	PUNCT
admet-31	85	43	f=1014	f=1014	PROPN
admet-31	85	44	,	,	PUNCT
admet-31	85	45	n=16	n=16	NOUN
admet-31	85	46	.	.	PUNCT
admet-31	85	47	table	table	NOUN
admet-31	85	48	1	1	NUM
admet-31	85	49	.	.	PUNCT
admet-31	86	1	summary	summary	NOUN
admet-31	86	2	of	of	ADP
admet-31	86	3	the	the	DET
admet-31	86	4	results	result	NOUN
admet-31	86	5	of	of	ADP
admet-31	86	6	the	the	DET
admet-31	86	7	re	re	NOUN
admet-31	86	8	-	-	NOUN
admet-31	86	9	analysis	analysis	NOUN
admet-31	86	10	of	of	ADP
admet-31	86	11	the	the	DET
admet-31	86	12	bergstrom	bergstrom	PROPN
admet-31	86	13	et	et	PROPN
admet-31	86	14	al	al	PROPN
admet-31	86	15	.	.	PUNCT
admet-31	87	1	[	[	X
admet-31	87	2	13	13	NUM
admet-31	87	3	]	]	PUNCT
admet-31	87	4	data	datum	NOUN
admet-31	87	5	.	.	PUNCT
admet-31	88	1	admet	admet	PROPN
admet-31	88	2	&	&	CCONJ
admet-31	88	3	dmpk	dmpk	PROPN
admet-31	88	4	2(1	2(1	NUM
admet-31	88	5	)	)	PUNCT
admet-31	88	6	(	(	PUNCT
admet-31	88	7	2014	2014	NUM
admet-31	88	8	)	)	PUNCT
admet-31	88	9	43	43	NUM
admet-31	88	10	-	-	SYM
admet-31	88	11	55	55	NUM
admet-31	88	12	phosphate	phosphate	NOUN
admet-31	88	13	precipitates	precipitate	NOUN
admet-31	88	14	&	&	CCONJ
admet-31	88	15	aggregates	aggregate	NOUN
admet-31	88	16	of	of	ADP
admet-31	88	17	basic	basic	ADJ
admet-31	88	18	drugs	drug	NOUN
admet-31	88	19	doi	doi	NOUN
admet-31	88	20	:	:	PUNCT
admet-31	88	21	10.5599	10.5599	NUM
admet-31	88	22	/	/	SYM
admet-31	88	23	admet.2.1.31	admet.2.1.31	PROPN
admet-31	88	24	47	47	NUM
admet-31	88	25	figure	figure	NOUN
admet-31	88	26	1	1	NUM
admet-31	88	27	.	.	PUNCT
admet-31	88	28	comparison	comparison	NOUN
admet-31	88	29	of	of	ADP
admet-31	88	30	previously	previously	ADV
admet-31	88	31	reported	report	VERB
admet-31	88	32	intrinsic	intrinsic	ADJ
admet-31	88	33	solubility	solubility	NOUN
admet-31	88	34	values	value	NOUN
admet-31	88	35	,	,	PUNCT
admet-31	88	36	ps0	ps0	X
admet-31	88	37	(	(	PUNCT
admet-31	88	38	molarity	molarity	NOUN
admet-31	88	39	based	base	VERB
admet-31	88	40	units	unit	NOUN
admet-31	88	41	)	)	PUNCT
admet-31	88	42	,	,	PUNCT
admet-31	88	43	to	to	ADP
admet-31	88	44	those	those	PRON
admet-31	88	45	determined	determine	VERB
admet-31	88	46	here	here	ADV
admet-31	88	47	.	.	PUNCT
admet-31	89	1	aggregation	aggregation	NOUN
admet-31	89	2	reactions	reaction	NOUN
admet-31	89	3	case	case	NOUN
admet-31	89	4	0	0	NUM
admet-31	89	5	–	–	PUNCT
admet-31	89	6	no	no	DET
admet-31	89	7	aggregation	aggregation	NOUN
admet-31	89	8	;	;	PUNCT
admet-31	89	9	henderson	henderson	PROPN
admet-31	89	10	-	-	PUNCT
admet-31	89	11	hasselbalch	hasselbalch	PROPN
admet-31	89	12	equation	equation	NOUN
admet-31	89	13	accurate	accurate	ADJ
admet-31	89	14	for	for	ADP
admet-31	89	15	ph	ph	PROPN
admet-31	89	16	>	>	X
admet-31	89	17	pka	pka	PROPN
admet-31	89	18	gibbs	gibbs	PROPN
admet-31	89	19	figure	figure	NOUN
admet-31	89	20	2	2	NUM
admet-31	89	21	shows	show	VERB
admet-31	89	22	the	the	DET
admet-31	89	23	six	six	NUM
admet-31	89	24	compounds	compound	NOUN
admet-31	89	25	which	which	PRON
admet-31	89	26	show	show	VERB
admet-31	89	27	no	no	DET
admet-31	89	28	appreciable	appreciable	ADJ
admet-31	89	29	deviation	deviation	NOUN
admet-31	89	30	from	from	ADP
admet-31	89	31	the	the	DET
admet-31	89	32	log	log	NOUN
admet-31	89	33	s	s	PART
admet-31	89	34	–	–	PUNCT
admet-31	89	35	ph	ph	ADJ
admet-31	89	36	curves	curve	NOUN
admet-31	89	37	calculated	calculate	VERB
admet-31	89	38	by	by	ADP
admet-31	89	39	the	the	DET
admet-31	89	40	henderson	henderson	PROPN
admet-31	89	41	-	-	PUNCT
admet-31	89	42	hasselbalch	hasselbalch	PROPN
admet-31	89	43	equation	equation	NOUN
admet-31	89	44	(	(	PUNCT
admet-31	89	45	non	non	ADJ
admet-31	89	46	-	-	ADJ
admet-31	89	47	salt	salt	ADJ
admet-31	89	48	region	region	NOUN
admet-31	89	49	:	:	PUNCT
admet-31	89	50	ph	ph	PROPN
admet-31	89	51	>	>	X
admet-31	89	52	pka	pka	PROPN
admet-31	89	53	gibbs	gibbs	PROPN
admet-31	89	54	)	)	PUNCT
admet-31	89	55	.	.	PUNCT
admet-31	90	1	the	the	DET
admet-31	90	2	compounds	compound	NOUN
admet-31	90	3	are	be	AUX
admet-31	90	4	arranged	arrange	VERB
admet-31	90	5	in	in	ADP
admet-31	90	6	the	the	DET
admet-31	90	7	order	order	NOUN
admet-31	90	8	of	of	ADP
admet-31	90	9	decreasing	decrease	VERB
admet-31	90	10	intrinsic	intrinsic	ADJ
admet-31	90	11	solubility	solubility	NOUN
admet-31	90	12	.	.	PUNCT
admet-31	91	1	carvedilol	carvedilol	PROPN
admet-31	91	2	and	and	CCONJ
admet-31	91	3	chlorprothixene	chlorprothixene	PROPN
admet-31	91	4	indicated	indicate	VERB
admet-31	91	5	the	the	DET
admet-31	91	6	lowest	low	ADJ
admet-31	91	7	intrinsic	intrinsic	ADJ
admet-31	91	8	solubility	solubility	NOUN
admet-31	91	9	,	,	PUNCT
admet-31	91	10	with	with	ADP
admet-31	91	11	values	value	NOUN
admet-31	91	12	<	<	X
admet-31	91	13	0.5	0.5	NUM
admet-31	91	14	µg∙ml-1	µg∙ml-1	PROPN
admet-31	91	15	.	.	PUNCT
admet-31	92	1	the	the	DET
admet-31	92	2	most	most	ADV
admet-31	92	3	soluble	soluble	ADJ
admet-31	92	4	molecule	molecule	NOUN
admet-31	92	5	is	be	AUX
admet-31	92	6	lidocaine	lidocaine	NOUN
admet-31	92	7	,	,	PUNCT
admet-31	92	8	with	with	SCONJ
admet-31	92	9	s0	s0	PROPN
admet-31	92	10	=	=	SYM
admet-31	92	11	2.5	2.5	NUM
admet-31	92	12	mg∙ml-1	mg∙ml-1	NOUN
admet-31	92	13	.	.	PUNCT
admet-31	93	1	the	the	DET
admet-31	93	2	ph	ph	NOUN
admet-31	93	3	at	at	ADP
admet-31	93	4	the	the	DET
admet-31	93	5	point	point	NOUN
admet-31	93	6	of	of	ADP
admet-31	93	7	discontinuity	discontinuity	NOUN
admet-31	93	8	between	between	ADP
admet-31	93	9	the	the	DET
admet-31	93	10	(	(	PUNCT
admet-31	93	11	most	most	ADV
admet-31	93	12	-	-	PUNCT
admet-31	93	13	often	often	ADV
admet-31	93	14	flat	flat	ADJ
admet-31	93	15	)	)	PUNCT
admet-31	93	16	salt	salt	NOUN
admet-31	93	17	region	region	NOUN
admet-31	93	18	and	and	CCONJ
admet-31	93	19	the	the	DET
admet-31	93	20	diagonal	diagonal	ADJ
admet-31	93	21	slope	slope	NOUN
admet-31	93	22	=	=	SYM
admet-31	93	23	-1	-1	NOUN
admet-31	93	24	curve	curve	NOUN
admet-31	93	25	is	be	AUX
admet-31	93	26	called	call	VERB
admet-31	93	27	pka	pka	PROPN
admet-31	93	28	gibbs	gibbs	PROPN
admet-31	94	1	[	[	X
admet-31	94	2	14,15	14,15	NUM
admet-31	94	3	]	]	X
admet-31	94	4	.	.	PUNCT
admet-31	95	1	for	for	ADP
admet-31	95	2	example	example	NOUN
admet-31	95	3	,	,	PUNCT
admet-31	95	4	pka	pka	PROPN
admet-31	95	5	gibbs	gibbs	PROPN
admet-31	95	6	=	=	PROPN
admet-31	95	7	6.2	6.2	NUM
admet-31	95	8	,	,	PUNCT
admet-31	95	9	9.2	9.2	NUM
admet-31	95	10	,	,	PUNCT
admet-31	95	11	7.0	7.0	NUM
admet-31	95	12	,	,	PUNCT
admet-31	95	13	2.9	2.9	NUM
admet-31	95	14	,	,	PUNCT
admet-31	95	15	6.7	6.7	NUM
admet-31	95	16	,	,	PUNCT
admet-31	95	17	6.0	6.0	NUM
admet-31	95	18	for	for	ADP
admet-31	95	19	the	the	DET
admet-31	95	20	drugs	drug	NOUN
admet-31	95	21	in	in	ADP
admet-31	95	22	figure	figure	NOUN
admet-31	95	23	2	2	NUM
admet-31	95	24	,	,	PUNCT
admet-31	95	25	in	in	ADP
admet-31	95	26	the	the	DET
admet-31	95	27	order	order	NOUN
admet-31	95	28	of	of	ADP
admet-31	95	29	their	their	PRON
admet-31	95	30	appearance	appearance	NOUN
admet-31	95	31	.	.	PUNCT
admet-31	96	1	with	with	ADP
admet-31	96	2	the	the	DET
admet-31	96	3	exception	exception	NOUN
admet-31	96	4	of	of	ADP
admet-31	96	5	verapamil	verapamil	NOUN
admet-31	96	6	and	and	CCONJ
admet-31	96	7	carvedilol	carvedilol	NOUN
admet-31	96	8	,	,	PUNCT
admet-31	96	9	simple	simple	ADJ
admet-31	96	10	2:1	2:1	NUM
admet-31	96	11	and/or	and/or	CCONJ
admet-31	96	12	1:1	1:1	NUM
admet-31	96	13	phosphate	phosphate	NOUN
admet-31	96	14	salts	salt	NOUN
admet-31	96	15	appear	appear	VERB
admet-31	96	16	to	to	PART
admet-31	96	17	form	form	VERB
admet-31	96	18	with	with	ADP
admet-31	96	19	this	this	DET
admet-31	96	20	class	class	NOUN
admet-31	96	21	of	of	ADP
admet-31	96	22	compounds	compound	NOUN
admet-31	96	23	.	.	PUNCT
admet-31	97	1	verapamil	verapamil	NOUN
admet-31	97	2	data	datum	NOUN
admet-31	97	3	in	in	ADP
admet-31	97	4	the	the	DET
admet-31	97	5	salt	salt	NOUN
admet-31	97	6	region	region	NOUN
admet-31	97	7	(	(	PUNCT
admet-31	97	8	ph	ph	X
admet-31	97	9	<	<	X
admet-31	97	10	pka	pka	PROPN
admet-31	97	11	gibbs	gibbs	PROPN
admet-31	97	12	)	)	PUNCT
admet-31	97	13	are	be	AUX
admet-31	97	14	consistent	consistent	ADJ
admet-31	97	15	with	with	ADP
admet-31	97	16	the	the	DET
admet-31	97	17	formation	formation	NOUN
admet-31	97	18	of	of	ADP
admet-31	97	19	a	a	DET
admet-31	97	20	chloride	chloride	NOUN
admet-31	97	21	salt	salt	NOUN
admet-31	97	22	with	with	ADP
admet-31	97	23	the	the	DET
admet-31	97	24	mixed	mix	VERB
admet-31	97	25	-	-	PUNCT
admet-31	97	26	charge	charge	NOUN
admet-31	97	27	dimer	dimer	NOUN
admet-31	97	28	of	of	ADP
admet-31	97	29	verapamil	verapamil	NOUN
admet-31	97	30	,	,	PUNCT
admet-31	97	31	(	(	PUNCT
admet-31	97	32	bhb+)∙cl-(s	bhb+)∙cl-(s	NUM
admet-31	97	33	)	)	PUNCT
admet-31	97	34	.	.	PUNCT
admet-31	98	1	the	the	DET
admet-31	98	2	region	region	NOUN
admet-31	98	3	below	below	ADP
admet-31	98	4	ph	ph	PROPN
admet-31	98	5	7	7	NUM
admet-31	98	6	displays	display	NOUN
admet-31	98	7	a	a	DET
admet-31	98	8	slope	slope	NOUN
admet-31	98	9	=	=	SYM
admet-31	98	10	-0.5	-0.5	PROPN
admet-31	98	11	,	,	PUNCT
admet-31	98	12	characteristic	characteristic	ADJ
admet-31	98	13	of	of	ADP
admet-31	98	14	such	such	DET
admet-31	98	15	a	a	DET
admet-31	98	16	stoichiometry	stoichiometry	NOUN
admet-31	98	17	.	.	PUNCT
admet-31	99	1	carvedilol	carvedilol	PROPN
admet-31	99	2	salt	salt	PROPN
admet-31	99	3	region	region	NOUN
admet-31	99	4	is	be	AUX
admet-31	99	5	best	well	ADV
admet-31	99	6	fit	fit	ADJ
admet-31	99	7	with	with	ADP
admet-31	99	8	a	a	DET
admet-31	99	9	diphosphate	diphosphate	ADJ
admet-31	99	10	stoichiometry	stoichiometry	NOUN
admet-31	99	11	:	:	PUNCT
admet-31	99	12	3	3	NUM
admet-31	99	13	bh+	bh+	NOUN
admet-31	99	14	+	+	CCONJ
admet-31	99	15	h2po4	h2po4	ADJ
admet-31	99	16	+	+	CCONJ
admet-31	99	17	hpo4	hpo4	NOUN
admet-31	99	18	2	2	NUM
admet-31	99	19	(	(	PUNCT
admet-31	99	20	bh)3h3(po4)2(s	bh)3h3(po4)2(s	NOUN
admet-31	99	21	)	)	PUNCT
admet-31	99	22	.	.	PUNCT
admet-31	100	1	verapamil	verapamil	NOUN
admet-31	100	2	and	and	CCONJ
admet-31	100	3	carvedilol	carvedilol	NOUN
admet-31	100	4	(	(	PUNCT
admet-31	100	5	and	and	CCONJ
admet-31	100	6	mifepristone	mifepristone	NOUN
admet-31	100	7	,	,	PUNCT
admet-31	100	8	below	below	ADV
admet-31	100	9	)	)	PUNCT
admet-31	100	10	illustrate	illustrate	VERB
admet-31	100	11	why	why	SCONJ
admet-31	100	12	it	it	PRON
admet-31	100	13	is	be	AUX
admet-31	100	14	better	well	ADJ
admet-31	100	15	to	to	PART
admet-31	100	16	designate	designate	VERB
admet-31	100	17	the	the	DET
admet-31	100	18	ph	ph	NOUN
admet-31	100	19	of	of	ADP
admet-31	100	20	discontinuity	discontinuity	NOUN
admet-31	100	21	as	as	ADP
admet-31	100	22	pka	pka	PROPN
admet-31	100	23	gibbs	gibbs	PROPN
admet-31	100	24	,	,	PUNCT
admet-31	100	25	rather	rather	ADV
admet-31	100	26	than	than	ADP
admet-31	100	27	“	"	PUNCT
admet-31	100	28	phmax	phmax	ADV
admet-31	100	29	,	,	PUNCT
admet-31	100	30	”	"	PUNCT
admet-31	100	31	since	since	SCONJ
admet-31	100	32	the	the	DET
admet-31	100	33	discontinuity	discontinuity	NOUN
admet-31	100	34	can	can	AUX
admet-31	100	35	occur	occur	VERB
admet-31	100	36	at	at	ADP
admet-31	100	37	a	a	DET
admet-31	100	38	ph	ph	NOUN
admet-31	100	39	where	where	SCONJ
admet-31	100	40	the	the	DET
admet-31	100	41	solubility	solubility	NOUN
admet-31	100	42	is	be	AUX
admet-31	100	43	not	not	PART
admet-31	100	44	at	at	ADV
admet-31	100	45	all	all	ADV
admet-31	100	46	at	at	ADP
admet-31	100	47	its	its	PRON
admet-31	100	48	maximum	maximum	ADJ
admet-31	100	49	value	value	NOUN
admet-31	100	50	[	[	X
admet-31	100	51	14,15	14,15	NUM
admet-31	100	52	]	]	PUNCT
admet-31	100	53	.	.	PUNCT
admet-31	101	1	avdeef	avdeef	PROPN
admet-31	101	2	admet	admet	PROPN
admet-31	101	3	&	&	CCONJ
admet-31	101	4	dmpk	dmpk	PROPN
admet-31	101	5	2(1	2(1	NUM
admet-31	101	6	)	)	PUNCT
admet-31	101	7	(	(	PUNCT
admet-31	101	8	2014	2014	NUM
admet-31	101	9	)	)	PUNCT
admet-31	101	10	43	43	NUM
admet-31	101	11	-	-	SYM
admet-31	101	12	55	55	NUM
admet-31	101	13	48	48	NUM
admet-31	101	14	figure	figure	NOUN
admet-31	101	15	2	2	NUM
admet-31	101	16	.	.	PUNCT
admet-31	101	17	case	case	NOUN
admet-31	101	18	0	0	NUM
admet-31	101	19	compounds	compound	NOUN
admet-31	101	20	which	which	PRON
admet-31	101	21	show	show	VERB
admet-31	101	22	henderson	henderson	PROPN
admet-31	101	23	-	-	PUNCT
admet-31	101	24	hasselbalch	hasselbalch	PROPN
admet-31	101	25	form	form	NOUN
admet-31	101	26	log	log	NOUN
admet-31	101	27	s	s	PART
admet-31	101	28	–	–	PUNCT
admet-31	101	29	ph	ph	ADJ
admet-31	101	30	curves	curve	NOUN
admet-31	101	31	in	in	ADP
admet-31	101	32	the	the	DET
admet-31	101	33	non	non	ADJ
admet-31	101	34	-	-	ADJ
admet-31	101	35	salt	salt	ADJ
admet-31	101	36	region	region	NOUN
admet-31	101	37	.	.	PUNCT
admet-31	102	1	case	case	NOUN
admet-31	102	2	1b	1b	NUM
admet-31	102	3	–	–	PUNCT
admet-31	102	4	neutral	neutral	ADJ
admet-31	102	5	aggregates	aggregate	NOUN
admet-31	102	6	;	;	PUNCT
admet-31	102	7	henderson	henderson	PROPN
admet-31	102	8	-	-	PUNCT
admet-31	102	9	hasselbalch	hasselbalch	PROPN
admet-31	102	10	equation	equation	NOUN
admet-31	102	11	not	not	PART
admet-31	102	12	accurate	accurate	ADJ
admet-31	102	13	figure	figure	NOUN
admet-31	102	14	3	3	NUM
admet-31	102	15	shows	show	VERB
admet-31	102	16	the	the	DET
admet-31	102	17	six	six	NUM
admet-31	102	18	compounds	compound	NOUN
admet-31	102	19	with	with	ADP
admet-31	102	20	apparent	apparent	ADJ
admet-31	102	21	pka	pka	PROPN
admet-31	102	22	<	<	X
admet-31	102	23	true	true	PROPN
admet-31	102	24	pka	pka	PROPN
admet-31	102	25	,	,	PUNCT
admet-31	102	26	which	which	PRON
admet-31	102	27	is	be	AUX
admet-31	102	28	consistent	consistent	ADJ
admet-31	102	29	with	with	ADP
admet-31	102	30	the	the	DET
admet-31	102	31	formation	formation	NOUN
admet-31	102	32	of	of	ADP
admet-31	102	33	water	water	NOUN
admet-31	102	34	-	-	PUNCT
admet-31	102	35	soluble	soluble	ADJ
admet-31	102	36	uncharged	uncharged	ADJ
admet-31	102	37	aggregates	aggregate	NOUN
admet-31	102	38	.	.	PUNCT
admet-31	103	1	the	the	DET
admet-31	103	2	henderson	henderson	PROPN
admet-31	103	3	-	-	PUNCT
admet-31	103	4	hasselbalch	hasselbalch	PROPN
admet-31	103	5	equation	equation	NOUN
admet-31	103	6	does	do	AUX
admet-31	103	7	not	not	PART
admet-31	103	8	accurately	accurately	ADV
admet-31	103	9	predict	predict	VERB
admet-31	103	10	the	the	DET
admet-31	103	11	log	log	NOUN
admet-31	103	12	s	s	PART
admet-31	103	13	–	–	PUNCT
admet-31	103	14	ph	ph	ADJ
admet-31	103	15	curves	curve	NOUN
admet-31	103	16	across	across	ADP
admet-31	103	17	the	the	DET
admet-31	103	18	entire	entire	ADJ
admet-31	103	19	ph	ph	ADJ
admet-31	103	20	range	range	NOUN
admet-31	103	21	.	.	PUNCT
admet-31	104	1	for	for	ADP
admet-31	104	2	case	case	NOUN
admet-31	104	3	1b	1b	NUM
admet-31	104	4	drugs	drug	NOUN
admet-31	104	5	,	,	PUNCT
admet-31	104	6	the	the	DET
admet-31	104	7	apparent	apparent	ADJ
admet-31	104	8	s0	s0	NOUN
admet-31	104	9	>	>	PUNCT
admet-31	104	10	true	true	ADJ
admet-31	104	11	s0	s0	PROPN
admet-31	104	12	.	.	PUNCT
admet-31	105	1	the	the	DET
admet-31	105	2	degree	degree	NOUN
admet-31	105	3	of	of	ADP
admet-31	105	4	aggregation	aggregation	NOUN
admet-31	105	5	can	can	AUX
admet-31	105	6	not	not	PART
admet-31	105	7	be	be	AUX
admet-31	105	8	determined	determine	VERB
admet-31	105	9	from	from	ADP
admet-31	105	10	ph	ph	ADJ
admet-31	105	11	-	-	NOUN
admet-31	105	12	dependence	dependence	NOUN
admet-31	105	13	,	,	PUNCT
admet-31	105	14	since	since	SCONJ
admet-31	105	15	the	the	DET
admet-31	105	16	aggregated	aggregate	VERB
admet-31	105	17	compound	compound	NOUN
admet-31	105	18	is	be	AUX
admet-31	105	19	in	in	ADP
admet-31	105	20	the	the	DET
admet-31	105	21	uncharged	uncharged	ADJ
admet-31	105	22	form	form	NOUN
admet-31	105	23	.	.	PUNCT
admet-31	106	1	the	the	DET
admet-31	106	2	compounds	compound	NOUN
admet-31	106	3	in	in	ADP
admet-31	106	4	figure	figure	NOUN
admet-31	106	5	3	3	NUM
admet-31	106	6	are	be	AUX
admet-31	106	7	arranged	arrange	VERB
admet-31	106	8	in	in	ADP
admet-31	106	9	the	the	DET
admet-31	106	10	increasing	increase	VERB
admet-31	106	11	order	order	NOUN
admet-31	106	12	of	of	ADP
admet-31	106	13	aggregation	aggregation	NOUN
admet-31	106	14	strength	strength	NOUN
admet-31	106	15	.	.	PUNCT
admet-31	107	1	figure	figure	VERB
admet-31	107	2	3	3	NUM
admet-31	107	3	.	.	PUNCT
admet-31	107	4	case	case	NOUN
admet-31	107	5	1b	1b	NUM
admet-31	107	6	compounds	compound	VERB
admet-31	107	7	:	:	PUNCT
admet-31	107	8	log	log	PROPN
admet-31	107	9	s	s	PART
admet-31	107	10	–	–	PUNCT
admet-31	107	11	ph	ph	ADJ
admet-31	107	12	curve	curve	NOUN
admet-31	107	13	distortions	distortion	NOUN
admet-31	107	14	consistent	consistent	ADJ
admet-31	107	15	with	with	ADP
admet-31	107	16	the	the	DET
admet-31	107	17	formation	formation	NOUN
admet-31	107	18	of	of	ADP
admet-31	107	19	neutral	neutral	ADJ
admet-31	107	20	aggregates	aggregate	NOUN
admet-31	107	21	.	.	PUNCT
admet-31	108	1	admet	admet	PROPN
admet-31	108	2	&	&	CCONJ
admet-31	108	3	dmpk	dmpk	PROPN
admet-31	108	4	2(1	2(1	NUM
admet-31	108	5	)	)	PUNCT
admet-31	108	6	(	(	PUNCT
admet-31	108	7	2014	2014	NUM
admet-31	108	8	)	)	PUNCT
admet-31	108	9	43	43	NUM
admet-31	108	10	-	-	SYM
admet-31	108	11	55	55	NUM
admet-31	108	12	phosphate	phosphate	NOUN
admet-31	108	13	precipitates	precipitate	NOUN
admet-31	108	14	&	&	CCONJ
admet-31	108	15	aggregates	aggregate	NOUN
admet-31	108	16	of	of	ADP
admet-31	108	17	basic	basic	ADJ
admet-31	108	18	drugs	drug	NOUN
admet-31	108	19	doi	doi	NOUN
admet-31	108	20	:	:	PUNCT
admet-31	108	21	10.5599	10.5599	NUM
admet-31	108	22	/	/	SYM
admet-31	108	23	admet.2.1.31	admet.2.1.31	PROPN
admet-31	108	24	49	49	NUM
admet-31	108	25	the	the	DET
admet-31	108	26	compounds	compound	NOUN
admet-31	108	27	in	in	ADP
admet-31	108	28	the	the	DET
admet-31	108	29	figure	figure	NOUN
admet-31	108	30	3	3	NUM
admet-31	108	31	either	either	ADV
admet-31	108	32	(	(	PUNCT
admet-31	108	33	i	i	NOUN
admet-31	108	34	)	)	PUNCT
admet-31	108	35	form	form	VERB
admet-31	108	36	stable	stable	ADJ
admet-31	108	37	water	water	NOUN
admet-31	108	38	-	-	PUNCT
admet-31	108	39	soluble	soluble	ADJ
admet-31	108	40	aggregates	aggregate	NOUN
admet-31	108	41	of	of	ADP
admet-31	108	42	the	the	DET
admet-31	108	43	uncharged	uncharged	ADJ
admet-31	108	44	drug	drug	NOUN
admet-31	108	45	,	,	PUNCT
admet-31	108	46	or	or	CCONJ
admet-31	108	47	(	(	PUNCT
admet-31	108	48	ii	ii	NOUN
admet-31	108	49	)	)	PUNCT
admet-31	108	50	the	the	DET
admet-31	108	51	compounds	compound	NOUN
admet-31	108	52	show	show	VERB
admet-31	108	53	a	a	DET
admet-31	108	54	pattern	pattern	NOUN
admet-31	108	55	of	of	ADP
admet-31	108	56	curve	curve	NOUN
admet-31	108	57	distortion	distortion	NOUN
admet-31	108	58	,	,	PUNCT
admet-31	108	59	which	which	PRON
admet-31	108	60	is	be	AUX
admet-31	108	61	characteristic	characteristic	ADJ
admet-31	108	62	of	of	ADP
admet-31	108	63	a	a	DET
admet-31	108	64	system	system	NOUN
admet-31	108	65	that	that	PRON
admet-31	108	66	had	have	AUX
admet-31	108	67	not	not	PART
admet-31	108	68	reached	reach	VERB
admet-31	108	69	a	a	DET
admet-31	108	70	true	true	ADJ
admet-31	108	71	state	state	NOUN
admet-31	108	72	of	of	ADP
admet-31	108	73	thermodynamic	thermodynamic	ADJ
admet-31	108	74	equilibrium	equilibrium	NOUN
admet-31	108	75	at	at	ADP
admet-31	108	76	the	the	DET
admet-31	108	77	24	24	NUM
admet-31	108	78	h	h	NOUN
admet-31	108	79	time	time	NOUN
admet-31	108	80	point	point	NOUN
admet-31	108	81	.	.	PUNCT
admet-31	109	1	that	that	PRON
admet-31	109	2	is	be	AUX
admet-31	109	3	,	,	PUNCT
admet-31	109	4	neutral	neutral	ADJ
admet-31	109	5	aggregates	aggregate	NOUN
admet-31	109	6	may	may	AUX
admet-31	109	7	be	be	AUX
admet-31	109	8	thermodynamically	thermodynamically	ADV
admet-31	109	9	unstable	unstable	ADJ
admet-31	109	10	and	and	CCONJ
admet-31	109	11	are	be	AUX
admet-31	109	12	very	very	ADV
admet-31	109	13	slowly	slowly	ADV
admet-31	109	14	coalescing	coalesce	VERB
admet-31	109	15	into	into	ADP
admet-31	109	16	solid	solid	ADJ
admet-31	109	17	form	form	NOUN
admet-31	109	18	.	.	PUNCT
admet-31	110	1	examples	example	NOUN
admet-31	110	2	of	of	ADP
admet-31	110	3	the	the	DET
admet-31	110	4	former	former	ADJ
admet-31	110	5	(	(	PUNCT
admet-31	110	6	i	i	NOUN
admet-31	110	7	)	)	PUNCT
admet-31	110	8	effect	effect	NOUN
admet-31	110	9	have	have	AUX
admet-31	110	10	been	be	AUX
admet-31	110	11	reported	report	VERB
admet-31	110	12	with	with	ADP
admet-31	110	13	molecules	molecule	NOUN
admet-31	110	14	like	like	ADP
admet-31	110	15	piroxicam	piroxicam	NOUN
admet-31	110	16	[	[	X
admet-31	110	17	1,5	1,5	NUM
admet-31	110	18	]	]	PUNCT
admet-31	110	19	,	,	PUNCT
admet-31	110	20	and	and	CCONJ
admet-31	110	21	cases	case	NOUN
admet-31	110	22	of	of	ADP
admet-31	110	23	the	the	DET
admet-31	110	24	latter	latter	ADJ
admet-31	110	25	(	(	PUNCT
admet-31	110	26	ii	ii	NOUN
admet-31	110	27	)	)	PUNCT
admet-31	110	28	effect	effect	NOUN
admet-31	110	29	have	have	AUX
admet-31	110	30	been	be	AUX
admet-31	110	31	reported	report	VERB
admet-31	110	32	for	for	ADP
admet-31	110	33	terfenadine	terfenadine	NOUN
admet-31	110	34	,	,	PUNCT
admet-31	110	35	which	which	PRON
admet-31	110	36	at	at	ADP
admet-31	110	37	24	24	NUM
admet-31	110	38	h	h	NOUN
admet-31	110	39	showed	show	VERB
admet-31	110	40	more	more	ADV
admet-31	110	41	pronounced	pronounced	ADJ
admet-31	110	42	distortion	distortion	NOUN
admet-31	110	43	that	that	SCONJ
admet-31	110	44	at	at	ADP
admet-31	110	45	68	68	NUM
admet-31	110	46	h	h	NOUN
admet-31	110	47	[	[	X
admet-31	110	48	1,5	1,5	NUM
admet-31	110	49	]	]	PUNCT
admet-31	110	50	(	(	PUNCT
admet-31	110	51	it	it	PRON
admet-31	110	52	would	would	AUX
admet-31	110	53	be	be	AUX
admet-31	110	54	useful	useful	ADJ
admet-31	110	55	to	to	PART
admet-31	110	56	repeat	repeat	VERB
admet-31	110	57	the	the	DET
admet-31	110	58	measurements	measurement	NOUN
admet-31	110	59	of	of	ADP
admet-31	110	60	the	the	DET
admet-31	110	61	six	six	NUM
admet-31	110	62	drugs	drug	NOUN
admet-31	110	63	in	in	ADP
admet-31	110	64	figure	figure	NOUN
admet-31	110	65	3	3	NUM
admet-31	110	66	at	at	ADP
admet-31	110	67	much	much	ADV
admet-31	110	68	longer	long	ADJ
admet-31	110	69	equilibration	equilibration	NOUN
admet-31	110	70	times	time	NOUN
admet-31	110	71	than	than	ADP
admet-31	110	72	the	the	DET
admet-31	110	73	24	24	NUM
admet-31	110	74	h	h	NOUN
admet-31	110	75	actually	actually	ADV
admet-31	110	76	used	use	VERB
admet-31	110	77	)	)	PUNCT
admet-31	110	78	.	.	PUNCT
admet-31	111	1	it	it	PRON
admet-31	111	2	is	be	AUX
admet-31	111	3	evident	evident	ADJ
admet-31	111	4	that	that	SCONJ
admet-31	111	5	to	to	PART
admet-31	111	6	analyze	analyze	VERB
admet-31	111	7	case	case	NOUN
admet-31	111	8	1b	1b	NUM
admet-31	111	9	compounds	compound	VERB
admet-31	111	10	,	,	PUNCT
admet-31	111	11	it	it	PRON
admet-31	111	12	is	be	AUX
admet-31	111	13	necessary	necessary	ADJ
admet-31	111	14	to	to	PART
admet-31	111	15	know	know	VERB
admet-31	111	16	the	the	DET
admet-31	111	17	true	true	ADJ
admet-31	111	18	pka	pka	PROPN
admet-31	111	19	accurately	accurately	ADV
admet-31	111	20	.	.	PUNCT
admet-31	112	1	it	it	PRON
admet-31	112	2	is	be	AUX
admet-31	112	3	with	with	ADP
admet-31	112	4	this	this	DET
admet-31	112	5	class	class	NOUN
admet-31	112	6	of	of	ADP
admet-31	112	7	compounds	compound	NOUN
admet-31	112	8	that	that	SCONJ
admet-31	112	9	there	there	PRON
admet-31	112	10	were	be	VERB
admet-31	112	11	the	the	DET
admet-31	112	12	largest	large	ADJ
admet-31	112	13	deviations	deviation	NOUN
admet-31	112	14	in	in	ADP
admet-31	112	15	figure	figure	NOUN
admet-31	112	16	1	1	NUM
admet-31	112	17	.	.	PUNCT
admet-31	113	1	apparently	apparently	ADV
admet-31	113	2	,	,	PUNCT
admet-31	113	3	the	the	DET
admet-31	113	4	published	publish	VERB
admet-31	113	5	intrinsic	intrinsic	ADJ
admet-31	113	6	values	value	NOUN
admet-31	113	7	[	[	X
admet-31	113	8	13	13	NUM
admet-31	113	9	]	]	PUNCT
admet-31	113	10	ascribed	ascribe	VERB
admet-31	113	11	the	the	DET
admet-31	113	12	reported	report	VERB
admet-31	113	13	intrinsic	intrinsic	ADJ
admet-31	113	14	solubility	solubility	NOUN
admet-31	113	15	to	to	ADP
admet-31	113	16	the	the	DET
admet-31	113	17	apparent	apparent	ADJ
admet-31	113	18	intrinsic	intrinsic	ADJ
admet-31	113	19	values	value	NOUN
admet-31	113	20	(	(	PUNCT
admet-31	113	21	the	the	DET
admet-31	113	22	minimum	minimum	ADJ
admet-31	113	23	red	red	ADJ
admet-31	113	24	(	(	PUNCT
admet-31	113	25	solid	solid	ADJ
admet-31	113	26	)	)	PUNCT
admet-31	113	27	curve	curve	NOUN
admet-31	113	28	value	value	NOUN
admet-31	113	29	rather	rather	ADV
admet-31	113	30	than	than	ADP
admet-31	113	31	the	the	DET
admet-31	113	32	minimum	minimum	NOUN
admet-31	113	33	dashed	dash	VERB
admet-31	113	34	curve	curve	NOUN
admet-31	113	35	value	value	NOUN
admet-31	113	36	)	)	PUNCT
admet-31	113	37	.	.	PUNCT
admet-31	114	1	the	the	DET
admet-31	114	2	six	six	NUM
admet-31	114	3	examples	example	NOUN
admet-31	114	4	in	in	ADP
admet-31	114	5	the	the	DET
admet-31	114	6	above	above	ADJ
admet-31	114	7	figure	figure	NOUN
admet-31	114	8	show	show	VERB
admet-31	114	9	flat	flat	ADJ
admet-31	114	10	curves	curve	NOUN
admet-31	114	11	in	in	ADP
admet-31	114	12	the	the	DET
admet-31	114	13	salt	salt	NOUN
admet-31	114	14	region	region	NOUN
admet-31	114	15	,	,	PUNCT
admet-31	114	16	corresponding	correspond	VERB
admet-31	114	17	to	to	ADP
admet-31	114	18	simple	simple	ADJ
admet-31	114	19	stoichiometry	stoichiometry	NOUN
admet-31	114	20	phosphate	phosphate	NOUN
admet-31	114	21	or	or	CCONJ
admet-31	114	22	chloride	chloride	NOUN
admet-31	114	23	salts	salt	NOUN
admet-31	114	24	.	.	PUNCT
admet-31	115	1	case	case	NOUN
admet-31	115	2	2b	2b	NOUN
admet-31	115	3	–	–	PUNCT
admet-31	115	4	cationic	cationic	ADJ
admet-31	115	5	aggregates	aggregate	NOUN
admet-31	115	6	;	;	PUNCT
admet-31	115	7	henderson	henderson	PROPN
admet-31	115	8	-	-	PUNCT
admet-31	115	9	hasselbalch	hasselbalch	PROPN
admet-31	115	10	equation	equation	NOUN
admet-31	115	11	not	not	PART
admet-31	115	12	accurate	accurate	ADJ
admet-31	115	13	figure	figure	NOUN
admet-31	115	14	4	4	NUM
admet-31	115	15	shows	show	VERB
admet-31	115	16	four	four	NUM
admet-31	115	17	compounds	compound	NOUN
admet-31	115	18	which	which	PRON
admet-31	115	19	show	show	VERB
admet-31	115	20	non	non	ADJ
admet-31	115	21	-	-	ADJ
admet-31	115	22	unit	unit	ADJ
admet-31	115	23	slopes	slope	NOUN
admet-31	115	24	in	in	ADP
admet-31	115	25	a	a	DET
admet-31	115	26	part	part	NOUN
admet-31	115	27	of	of	ADP
admet-31	115	28	the	the	DET
admet-31	115	29	diagonal	diagonal	ADJ
admet-31	115	30	region	region	NOUN
admet-31	115	31	of	of	ADP
admet-31	115	32	the	the	DET
admet-31	115	33	log	log	NOUN
admet-31	115	34	s	s	NOUN
admet-31	115	35	ph	ph	NOUN
admet-31	115	36	profile	profile	NOUN
admet-31	115	37	.	.	PUNCT
admet-31	116	1	this	this	PRON
admet-31	116	2	is	be	AUX
admet-31	116	3	consistent	consistent	ADJ
admet-31	116	4	with	with	ADP
admet-31	116	5	the	the	DET
admet-31	116	6	formation	formation	NOUN
admet-31	116	7	cationic	cationic	ADJ
admet-31	116	8	aggregates	aggregate	NOUN
admet-31	116	9	.	.	PUNCT
admet-31	117	1	the	the	DET
admet-31	117	2	average	average	ADJ
admet-31	117	3	degree	degree	NOUN
admet-31	117	4	of	of	ADP
admet-31	117	5	aggregation	aggregation	NOUN
admet-31	117	6	is	be	AUX
admet-31	117	7	defined	define	VERB
admet-31	117	8	by	by	ADP
admet-31	117	9	the	the	DET
admet-31	117	10	value	value	NOUN
admet-31	117	11	of	of	ADP
admet-31	117	12	the	the	DET
admet-31	117	13	slope	slope	NOUN
admet-31	117	14	.	.	PUNCT
admet-31	118	1	apparent	apparent	ADJ
admet-31	118	2	s0	s0	PROPN
admet-31	118	3	=	=	PUNCT
admet-31	118	4	true	true	ADJ
admet-31	118	5	s0	s0	PROPN
admet-31	118	6	.	.	PUNCT
admet-31	118	7	figure	figure	NOUN
admet-31	118	8	4	4	NUM
admet-31	118	9	.	.	PUNCT
admet-31	118	10	case	case	NOUN
admet-31	118	11	2b	2b	NUM
admet-31	118	12	compounds	compound	NOUN
admet-31	118	13	which	which	PRON
admet-31	118	14	show	show	VERB
admet-31	118	15	log	log	NOUN
admet-31	118	16	s	s	PART
admet-31	118	17	–	–	PUNCT
admet-31	118	18	ph	ph	ADJ
admet-31	118	19	curve	curve	NOUN
admet-31	118	20	distortions	distortion	NOUN
admet-31	118	21	consistent	consistent	ADJ
admet-31	118	22	with	with	ADP
admet-31	118	23	the	the	DET
admet-31	118	24	formation	formation	NOUN
admet-31	118	25	of	of	ADP
admet-31	118	26	cationic	cationic	ADJ
admet-31	118	27	aggregates	aggregate	NOUN
admet-31	118	28	.	.	PUNCT
admet-31	119	1	bupivacaine	bupivacaine	NOUN
admet-31	119	2	analyzed	analyze	VERB
admet-31	119	3	as	as	ADP
admet-31	119	4	consisting	consist	VERB
admet-31	119	5	of	of	ADP
admet-31	119	6	(	(	PUNCT
admet-31	119	7	bh+)2	bh+)2	ADJ
admet-31	119	8	cationic	cationic	ADJ
admet-31	119	9	dimers	dimer	NOUN
admet-31	119	10	for	for	ADP
admet-31	119	11	ph	ph	NOUN
admet-31	119	12	<	<	X
admet-31	119	13	7	7	NUM
admet-31	119	14	,	,	PUNCT
admet-31	119	15	co	co	VERB
admet-31	119	16	-	-	VERB
admet-31	119	17	existing	exist	VERB
admet-31	119	18	with	with	ADP
admet-31	119	19	the	the	DET
admet-31	119	20	1:1	1:1	NUM
admet-31	119	21	phosphate	phosphate	NOUN
admet-31	119	22	precipitate	precipitate	NOUN
admet-31	119	23	.	.	PUNCT
admet-31	120	1	this	this	PRON
admet-31	120	2	raises	raise	VERB
admet-31	120	3	the	the	DET
admet-31	120	4	observed	observed	ADJ
admet-31	120	5	solubility	solubility	NOUN
admet-31	120	6	in	in	ADP
admet-31	120	7	the	the	DET
admet-31	120	8	salt	salt	NOUN
admet-31	120	9	region	region	NOUN
admet-31	120	10	,	,	PUNCT
admet-31	120	11	due	due	ADP
admet-31	120	12	to	to	ADP
admet-31	120	13	competition	competition	NOUN
admet-31	120	14	between	between	ADP
admet-31	120	15	avdeef	avdeef	PROPN
admet-31	120	16	admet	admet	PROPN
admet-31	120	17	&	&	CCONJ
admet-31	120	18	dmpk	dmpk	PROPN
admet-31	120	19	2(1	2(1	NUM
admet-31	120	20	)	)	PUNCT
admet-31	120	21	(	(	PUNCT
admet-31	120	22	2014	2014	NUM
admet-31	120	23	)	)	PUNCT
admet-31	120	24	43	43	NUM
admet-31	120	25	-	-	SYM
admet-31	120	26	55	55	NUM
admet-31	120	27	50	50	NUM
admet-31	120	28	the	the	DET
admet-31	120	29	drug	drug	NOUN
admet-31	120	30	in	in	ADP
admet-31	120	31	the	the	DET
admet-31	120	32	solid	solid	ADJ
admet-31	120	33	and	and	CCONJ
admet-31	120	34	aggregated	aggregated	ADJ
admet-31	120	35	states	state	NOUN
admet-31	120	36	.	.	PUNCT
admet-31	121	1	consequently	consequently	ADV
admet-31	121	2	,	,	PUNCT
admet-31	121	3	greater	great	ADJ
admet-31	121	4	amount	amount	NOUN
admet-31	121	5	of	of	ADP
admet-31	121	6	compound	compound	NOUN
admet-31	121	7	added	add	VERB
admet-31	121	8	to	to	ADP
admet-31	121	9	solution	solution	NOUN
admet-31	121	10	makes	make	VERB
admet-31	121	11	the	the	DET
admet-31	121	12	compound	compound	NOUN
admet-31	121	13	more	more	ADV
admet-31	121	14	soluble	soluble	ADJ
admet-31	121	15	in	in	ADP
admet-31	121	16	the	the	DET
admet-31	121	17	salt	salt	NOUN
admet-31	121	18	region	region	NOUN
admet-31	121	19	.	.	PUNCT
admet-31	122	1	the	the	DET
admet-31	122	2	data	data	NOUN
admet-31	122	3	shape	shape	NOUN
admet-31	122	4	of	of	ADP
admet-31	122	5	the	the	DET
admet-31	122	6	other	other	ADJ
admet-31	122	7	three	three	NUM
admet-31	122	8	molecules	molecule	NOUN
admet-31	122	9	was	be	AUX
admet-31	122	10	most	most	ADV
admet-31	122	11	consistent	consistent	ADJ
admet-31	122	12	with	with	ADP
admet-31	122	13	the	the	DET
admet-31	122	14	presence	presence	NOUN
admet-31	122	15	of	of	ADP
admet-31	122	16	pentameric	pentameric	NOUN
admet-31	122	17	or	or	CCONJ
admet-31	122	18	hexameric	hexameric	ADJ
admet-31	122	19	cationic	cationic	ADJ
admet-31	122	20	aggregates	aggregate	NOUN
admet-31	122	21	.	.	PUNCT
admet-31	123	1	it	it	PRON
admet-31	123	2	was	be	AUX
admet-31	123	3	possible	possible	ADJ
admet-31	123	4	to	to	PART
admet-31	123	5	rationalize	rationalize	VERB
admet-31	123	6	the	the	DET
admet-31	123	7	amiodarone	amiodarone	NOUN
admet-31	123	8	log	log	NOUN
admet-31	123	9	s	s	PART
admet-31	123	10	–	–	PUNCT
admet-31	123	11	ph	ph	NOUN
admet-31	123	12	profile	profile	NOUN
admet-31	123	13	as	as	ADP
admet-31	123	14	being	be	AUX
admet-31	123	15	distorted	distort	VERB
admet-31	123	16	from	from	ADP
admet-31	123	17	the	the	DET
admet-31	123	18	shape	shape	NOUN
admet-31	123	19	predicted	predict	VERB
admet-31	123	20	by	by	ADP
admet-31	123	21	the	the	DET
admet-31	123	22	henderson	henderson	PROPN
admet-31	123	23	-	-	PUNCT
admet-31	123	24	hasselbalch	hasselbalch	PROPN
admet-31	123	25	equation	equation	NOUN
admet-31	123	26	due	due	ADP
admet-31	123	27	to	to	ADP
admet-31	123	28	the	the	DET
admet-31	123	29	formation	formation	NOUN
admet-31	123	30	of	of	ADP
admet-31	123	31	the	the	DET
admet-31	123	32	pentamer	pentamer	NOUN
admet-31	123	33	(	(	PUNCT
admet-31	123	34	bh	bh	NOUN
admet-31	123	35	+	+	CCONJ
admet-31	123	36	)	)	PUNCT
admet-31	123	37	5	5	X
admet-31	123	38	.	.	PUNCT
admet-31	124	1	if	if	SCONJ
admet-31	124	2	this	this	PRON
admet-31	124	3	were	be	AUX
admet-31	124	4	a	a	DET
admet-31	124	5	valid	valid	ADJ
admet-31	124	6	interpretation	interpretation	NOUN
admet-31	124	7	of	of	ADP
admet-31	124	8	the	the	DET
admet-31	124	9	data	datum	NOUN
admet-31	124	10	,	,	PUNCT
admet-31	124	11	then	then	ADV
admet-31	124	12	there	there	PRON
admet-31	124	13	are	be	VERB
admet-31	124	14	some	some	DET
admet-31	124	15	very	very	ADV
admet-31	124	16	interesting	interesting	ADJ
admet-31	124	17	consequences	consequence	NOUN
admet-31	124	18	.	.	PUNCT
admet-31	125	1	in	in	ADP
admet-31	125	2	the	the	DET
admet-31	125	3	analysis	analysis	NOUN
admet-31	125	4	of	of	ADP
admet-31	125	5	the	the	DET
admet-31	125	6	amiodarone	amiodarone	NOUN
admet-31	125	7	data	datum	NOUN
admet-31	125	8	,	,	PUNCT
admet-31	125	9	it	it	PRON
admet-31	125	10	was	be	AUX
admet-31	125	11	assumed	assume	VERB
admet-31	125	12	that	that	SCONJ
admet-31	125	13	5	5	NUM
admet-31	125	14	mg	mg	NOUN
admet-31	125	15	of	of	ADP
admet-31	125	16	drug	drug	NOUN
admet-31	125	17	were	be	AUX
admet-31	125	18	added	add	VERB
admet-31	125	19	to	to	ADP
admet-31	125	20	1	1	NUM
admet-31	125	21	ml	ml	NOUN
admet-31	125	22	of	of	ADP
admet-31	125	23	buffer	buffer	NOUN
admet-31	125	24	.	.	PUNCT
admet-31	126	1	the	the	DET
admet-31	126	2	ph	ph	NOUN
admet-31	126	3	<	<	X
admet-31	126	4	5	5	NUM
admet-31	126	5	region	region	NOUN
admet-31	126	6	of	of	ADP
admet-31	126	7	solubility	solubility	NOUN
admet-31	126	8	curve	curve	NOUN
admet-31	126	9	(	(	PUNCT
admet-31	126	10	fig	fig	NOUN
admet-31	126	11	.	.	PUNCT
admet-31	127	1	4c	4c	NOUN
admet-31	127	2	)	)	PUNCT
admet-31	127	3	depends	depend	VERB
admet-31	127	4	on	on	ADP
admet-31	127	5	both	both	CCONJ
admet-31	127	6	the	the	DET
admet-31	127	7	presence	presence	NOUN
admet-31	127	8	of	of	ADP
admet-31	127	9	the	the	DET
admet-31	127	10	cationic	cationic	ADJ
admet-31	127	11	aggregate	aggregate	NOUN
admet-31	127	12	and	and	CCONJ
admet-31	127	13	the	the	DET
admet-31	127	14	phosphate	phosphate	ADJ
admet-31	127	15	precipitate	precipitate	NOUN
admet-31	127	16	.	.	PUNCT
admet-31	128	1	since	since	SCONJ
admet-31	128	2	the	the	DET
admet-31	128	3	concentration	concentration	NOUN
admet-31	128	4	of	of	ADP
admet-31	128	5	the	the	DET
admet-31	128	6	aggregate	aggregate	NOUN
admet-31	128	7	depends	depend	VERB
admet-31	128	8	steeply	steeply	ADV
admet-31	128	9	on	on	ADP
admet-31	128	10	the	the	DET
admet-31	128	11	amount	amount	NOUN
admet-31	128	12	of	of	ADP
admet-31	128	13	amiodarone	amiodarone	NOUN
admet-31	128	14	added	add	VERB
admet-31	128	15	to	to	ADP
admet-31	128	16	the	the	DET
admet-31	128	17	buffer	buffer	NOUN
admet-31	128	18	,	,	PUNCT
admet-31	128	19	a	a	DET
admet-31	128	20	series	series	NOUN
admet-31	128	21	of	of	ADP
admet-31	128	22	simulations	simulation	NOUN
admet-31	128	23	with	with	ADP
admet-31	128	24	decreasing	decrease	VERB
admet-31	128	25	amounts	amount	NOUN
admet-31	128	26	of	of	ADP
admet-31	128	27	amiodarone	amiodarone	NOUN
admet-31	128	28	results	result	NOUN
admet-31	128	29	in	in	ADP
admet-31	128	30	lowering	lower	VERB
admet-31	128	31	the	the	DET
admet-31	128	32	solubility	solubility	NOUN
admet-31	128	33	in	in	ADP
admet-31	128	34	the	the	DET
admet-31	128	35	salt	salt	NOUN
admet-31	128	36	region	region	NOUN
admet-31	128	37	.	.	PUNCT
admet-31	129	1	in	in	ADP
admet-31	129	2	the	the	DET
admet-31	129	3	extreme	extreme	ADJ
admet-31	129	4	,	,	PUNCT
admet-31	129	5	maximum	maximum	ADJ
admet-31	129	6	solubility	solubility	NOUN
admet-31	129	7	can	can	AUX
admet-31	129	8	decrease	decrease	VERB
admet-31	129	9	from	from	ADP
admet-31	129	10	about	about	ADV
admet-31	129	11	10	10	NUM
admet-31	129	12	-	-	SYM
admet-31	129	13	2	2	NUM
admet-31	129	14	(	(	PUNCT
admet-31	129	15	fig	fig	NOUN
admet-31	129	16	.	.	PUNCT
admet-31	129	17	4c	4c	NOUN
admet-31	129	18	)	)	PUNCT
admet-31	129	19	to	to	ADP
admet-31	129	20	10	10	NUM
admet-31	129	21	-7	-7	NOUN
admet-31	129	22	m	m	PROPN
admet-31	129	23	(	(	PUNCT
admet-31	129	24	not	not	PART
admet-31	129	25	shown	show	VERB
admet-31	129	26	)	)	PUNCT
admet-31	129	27	.	.	PUNCT
admet-31	130	1	this	this	PRON
admet-31	130	2	suggests	suggest	VERB
admet-31	130	3	that	that	SCONJ
admet-31	130	4	a	a	DET
admet-31	130	5	parenteral	parenteral	ADJ
admet-31	130	6	injectable	injectable	ADJ
admet-31	130	7	solution	solution	NOUN
admet-31	130	8	can	can	AUX
admet-31	130	9	show	show	VERB
admet-31	130	10	solubility	solubility	NOUN
admet-31	130	11	as	as	ADV
admet-31	130	12	high	high	ADJ
admet-31	130	13	as	as	ADP
admet-31	130	14	5	5	NUM
admet-31	130	15	mg∙ml	mg∙ml	NOUN
admet-31	130	16	-1	-1	NOUN
admet-31	130	17	in	in	ADP
admet-31	130	18	the	the	DET
admet-31	130	19	ph	ph	ADJ
admet-31	130	20	1	1	NUM
admet-31	130	21	-	-	SYM
admet-31	130	22	5	5	NUM
admet-31	130	23	region	region	NOUN
admet-31	130	24	,	,	PUNCT
admet-31	130	25	provided	provide	VERB
admet-31	130	26	enough	enough	ADJ
admet-31	130	27	drug	drug	NOUN
admet-31	130	28	were	be	AUX
admet-31	130	29	present	present	ADJ
admet-31	130	30	in	in	ADP
admet-31	130	31	the	the	DET
admet-31	130	32	formulation	formulation	NOUN
admet-31	130	33	.	.	PUNCT
admet-31	131	1	however	however	ADV
admet-31	131	2	,	,	PUNCT
admet-31	131	3	if	if	SCONJ
admet-31	131	4	a	a	DET
admet-31	131	5	much	much	ADV
admet-31	131	6	smaller	small	ADJ
admet-31	131	7	amount	amount	NOUN
admet-31	131	8	of	of	ADP
admet-31	131	9	drug	drug	NOUN
admet-31	131	10	were	be	AUX
admet-31	131	11	added	add	VERB
admet-31	131	12	,	,	PUNCT
admet-31	131	13	then	then	ADV
admet-31	131	14	the	the	DET
admet-31	131	15	solubility	solubility	NOUN
admet-31	131	16	could	could	AUX
admet-31	131	17	be	be	AUX
admet-31	131	18	limited	limit	VERB
admet-31	131	19	by	by	ADP
admet-31	131	20	the	the	DET
admet-31	131	21	apparent	apparent	ADJ
admet-31	131	22	minimum	minimum	NOUN
admet-31	131	23	pksp,1:1	pksp,1:1	NOUN
admet-31	131	24	(	(	PUNCT
admet-31	131	25	-log10	-log10	X
admet-31	131	26	ksp,1:1	ksp,1:1	PROPN
admet-31	131	27	)	)	PUNCT
admet-31	131	28	,	,	PUNCT
admet-31	131	29	to	to	ADP
admet-31	131	30	about	about	ADV
admet-31	131	31	14	14	NUM
admet-31	131	32	ng∙ml-1	ng∙ml-1	PROPN
admet-31	131	33	,	,	PUNCT
admet-31	131	34	with	with	ADP
admet-31	131	35	no	no	DET
admet-31	131	36	influence	influence	NOUN
admet-31	131	37	of	of	ADP
admet-31	131	38	the	the	DET
admet-31	131	39	aggregate	aggregate	NOUN
admet-31	131	40	,	,	PUNCT
admet-31	131	41	according	accord	VERB
admet-31	131	42	to	to	ADP
admet-31	131	43	the	the	DET
admet-31	131	44	pdisol	pdisol	ADJ
admet-31	131	45	-	-	PUNCT
admet-31	131	46	x	x	SYM
admet-31	131	47	simulation	simulation	NOUN
admet-31	131	48	calculation	calculation	NOUN
admet-31	131	49	.	.	PUNCT
admet-31	132	1	amiodarone	amiodarone	NOUN
admet-31	132	2	is	be	AUX
admet-31	132	3	the	the	DET
admet-31	132	4	drug	drug	NOUN
admet-31	132	5	of	of	ADP
admet-31	132	6	choice	choice	NOUN
admet-31	132	7	in	in	ADP
admet-31	132	8	the	the	DET
admet-31	132	9	treatment	treatment	NOUN
admet-31	132	10	of	of	ADP
admet-31	132	11	arrhythmia	arrhythmia	NOUN
admet-31	132	12	,	,	PUNCT
admet-31	132	13	but	but	CCONJ
admet-31	132	14	it	it	PRON
admet-31	132	15	has	have	VERB
admet-31	132	16	side	side	ADJ
admet-31	132	17	effects	effect	NOUN
admet-31	132	18	that	that	PRON
admet-31	132	19	limit	limit	VERB
admet-31	132	20	its	its	PRON
admet-31	132	21	long	long	ADJ
admet-31	132	22	-	-	PUNCT
admet-31	132	23	term	term	NOUN
admet-31	132	24	use	use	NOUN
admet-31	132	25	.	.	PUNCT
admet-31	133	1	in	in	ADP
admet-31	133	2	the	the	DET
admet-31	133	3	treatment	treatment	NOUN
admet-31	133	4	of	of	ADP
admet-31	133	5	chronic	chronic	ADJ
admet-31	133	6	arrhythmia	arrhythmia	NOUN
admet-31	133	7	,	,	PUNCT
admet-31	133	8	oral	oral	ADJ
admet-31	133	9	doses	dose	NOUN
admet-31	133	10	of	of	ADP
admet-31	133	11	amiodarone	amiodarone	NOUN
admet-31	133	12	may	may	AUX
admet-31	133	13	take	take	VERB
admet-31	133	14	30	30	NUM
admet-31	133	15	days	day	NOUN
admet-31	133	16	to	to	PART
admet-31	133	17	develop	develop	VERB
admet-31	133	18	full	full	ADJ
admet-31	133	19	therapeutic	therapeutic	ADJ
admet-31	133	20	effect	effect	NOUN
admet-31	133	21	because	because	SCONJ
admet-31	133	22	of	of	ADP
admet-31	133	23	the	the	DET
admet-31	133	24	extreme	extreme	ADJ
admet-31	133	25	hydrophobicity	hydrophobicity	NOUN
admet-31	133	26	of	of	ADP
admet-31	133	27	the	the	DET
admet-31	133	28	drug	drug	NOUN
admet-31	133	29	.	.	PUNCT
admet-31	134	1	once	once	SCONJ
admet-31	134	2	treatment	treatment	NOUN
admet-31	134	3	is	be	AUX
admet-31	134	4	discontinued	discontinue	VERB
admet-31	134	5	,	,	PUNCT
admet-31	134	6	it	it	PRON
admet-31	134	7	may	may	AUX
admet-31	134	8	take	take	VERB
admet-31	134	9	1	1	NUM
admet-31	134	10	-	-	SYM
admet-31	134	11	2	2	NUM
admet-31	134	12	months	month	NOUN
admet-31	134	13	to	to	PART
admet-31	134	14	wash	wash	VERB
admet-31	134	15	out	out	ADP
admet-31	134	16	the	the	DET
admet-31	134	17	drug	drug	NOUN
admet-31	134	18	completely	completely	ADV
admet-31	134	19	.	.	PUNCT
admet-31	135	1	on	on	ADP
admet-31	135	2	the	the	DET
admet-31	135	3	other	other	ADJ
admet-31	135	4	hand	hand	NOUN
admet-31	135	5	,	,	PUNCT
admet-31	135	6	during	during	ADP
admet-31	135	7	recovery	recovery	NOUN
admet-31	135	8	from	from	ADP
admet-31	135	9	heart	heart	NOUN
admet-31	135	10	surgery	surgery	NOUN
admet-31	135	11	,	,	PUNCT
admet-31	135	12	the	the	DET
admet-31	135	13	atrium	atrium	NOUN
admet-31	135	14	can	can	AUX
admet-31	135	15	start	start	VERB
admet-31	135	16	to	to	PART
admet-31	135	17	fibrillate	fibrillate	VERB
admet-31	135	18	dangerously	dangerously	ADV
admet-31	135	19	.	.	PUNCT
admet-31	136	1	one	one	NUM
admet-31	136	2	remedy	remedy	NOUN
admet-31	136	3	is	be	AUX
admet-31	136	4	to	to	PART
admet-31	136	5	inject	inject	VERB
admet-31	136	6	an	an	DET
admet-31	136	7	amiodarone	amiodarone	NOUN
admet-31	136	8	parenteral	parenteral	ADJ
admet-31	136	9	formulation	formulation	NOUN
admet-31	136	10	[	[	X
admet-31	136	11	16	16	NUM
admet-31	136	12	]	]	PUNCT
admet-31	136	13	into	into	ADP
admet-31	136	14	a	a	DET
admet-31	136	15	vessel	vessel	NOUN
admet-31	136	16	carrying	carry	VERB
admet-31	136	17	blood	blood	NOUN
admet-31	136	18	into	into	ADP
admet-31	136	19	the	the	DET
admet-31	136	20	heart	heart	NOUN
admet-31	136	21	.	.	PUNCT
admet-31	137	1	within	within	ADP
admet-31	137	2	a	a	DET
admet-31	137	3	few	few	ADJ
admet-31	137	4	minutes	minute	NOUN
admet-31	137	5	,	,	PUNCT
admet-31	137	6	the	the	DET
admet-31	137	7	drug	drug	NOUN
admet-31	137	8	can	can	AUX
admet-31	137	9	take	take	VERB
admet-31	137	10	effect	effect	NOUN
admet-31	137	11	.	.	PUNCT
admet-31	138	1	the	the	DET
admet-31	138	2	analysis	analysis	NOUN
admet-31	138	3	of	of	ADP
admet-31	138	4	the	the	DET
admet-31	138	5	log	log	NOUN
admet-31	138	6	s	s	PART
admet-31	138	7	–	–	PUNCT
admet-31	138	8	ph	ph	ADJ
admet-31	138	9	profile	profile	NOUN
admet-31	138	10	of	of	ADP
admet-31	138	11	amiodarone	amiodarone	NOUN
admet-31	138	12	can	can	AUX
admet-31	138	13	shed	shed	VERB
admet-31	138	14	light	light	NOUN
admet-31	138	15	on	on	ADP
admet-31	138	16	the	the	DET
admet-31	138	17	above	above	ADJ
admet-31	138	18	two	two	NUM
admet-31	138	19	seemingly	seemingly	ADV
admet-31	138	20	incompatible	incompatible	ADJ
admet-31	138	21	circumstances	circumstance	NOUN
admet-31	138	22	.	.	PUNCT
admet-31	139	1	hydralazine	hydralazine	PROPN
admet-31	139	2	was	be	AUX
admet-31	139	3	problematic	problematic	ADJ
admet-31	139	4	to	to	PART
admet-31	139	5	analyze	analyze	VERB
admet-31	139	6	.	.	PUNCT
admet-31	140	1	figure	figure	NOUN
admet-31	140	2	4d	4d	PROPN
admet-31	140	3	shows	show	VERB
admet-31	140	4	a	a	DET
admet-31	140	5	red	red	ADJ
admet-31	140	6	(	(	PUNCT
admet-31	140	7	solid	solid	ADJ
admet-31	140	8	)	)	PUNCT
admet-31	140	9	curve	curve	NOUN
admet-31	140	10	based	base	VERB
admet-31	140	11	on	on	ADP
admet-31	140	12	the	the	DET
admet-31	140	13	assumed	assumed	ADJ
admet-31	140	14	presence	presence	NOUN
admet-31	140	15	of	of	ADP
admet-31	140	16	a	a	DET
admet-31	140	17	hexameric	hexameric	NOUN
admet-31	140	18	(	(	PUNCT
admet-31	140	19	bh+)6	bh+)6	NOUN
admet-31	140	20	species	specie	NOUN
admet-31	140	21	,	,	PUNCT
admet-31	140	22	which	which	PRON
admet-31	140	23	is	be	AUX
admet-31	140	24	most	most	ADV
admet-31	140	25	consistent	consistent	ADJ
admet-31	140	26	with	with	ADP
admet-31	140	27	the	the	DET
admet-31	140	28	data	datum	NOUN
admet-31	140	29	that	that	PRON
admet-31	140	30	deviates	deviate	VERB
admet-31	140	31	most	most	ADV
admet-31	140	32	from	from	ADP
admet-31	140	33	the	the	DET
admet-31	140	34	dashed	dash	VERB
admet-31	140	35	line	line	NOUN
admet-31	140	36	in	in	ADP
admet-31	140	37	the	the	DET
admet-31	140	38	non	non	ADJ
admet-31	140	39	-	-	ADJ
admet-31	140	40	salt	salt	ADJ
admet-31	140	41	region	region	NOUN
admet-31	140	42	.	.	PUNCT
admet-31	141	1	however	however	ADV
admet-31	141	2	,	,	PUNCT
admet-31	141	3	the	the	DET
admet-31	141	4	consequence	consequence	NOUN
admet-31	141	5	of	of	ADP
admet-31	141	6	such	such	DET
admet-31	141	7	a	a	DET
admet-31	141	8	species	specie	NOUN
admet-31	141	9	being	be	AUX
admet-31	141	10	present	present	ADJ
admet-31	141	11	in	in	ADP
admet-31	141	12	parallel	parallel	NOUN
admet-31	141	13	with	with	ADP
admet-31	141	14	the	the	DET
admet-31	141	15	phosphate	phosphate	ADJ
admet-31	141	16	precipitate	precipitate	NOUN
admet-31	141	17	is	be	AUX
admet-31	141	18	that	that	SCONJ
admet-31	141	19	the	the	DET
admet-31	141	20	pksp,1:1	pksp,1:1	PROPN
admet-31	141	21	would	would	AUX
admet-31	141	22	analyze	analyze	VERB
admet-31	141	23	as	as	ADP
admet-31	141	24	5.12	5.12	NUM
admet-31	141	25	±	±	NUM
admet-31	141	26	0.24	0.24	NUM
admet-31	141	27	(	(	PUNCT
admet-31	141	28	the	the	DET
admet-31	141	29	value	value	NOUN
admet-31	141	30	in	in	ADP
admet-31	141	31	table	table	NOUN
admet-31	141	32	1	1	NUM
admet-31	141	33	)	)	PUNCT
admet-31	141	34	.	.	PUNCT
admet-31	142	1	since	since	SCONJ
admet-31	142	2	the	the	DET
admet-31	142	3	ps0	ps0	ADJ
admet-31	142	4	value	value	NOUN
admet-31	142	5	is	be	AUX
admet-31	142	6	unaffected	unaffected	ADJ
admet-31	142	7	by	by	ADP
admet-31	142	8	the	the	DET
admet-31	142	9	cationic	cationic	ADJ
admet-31	142	10	aggregate	aggregate	NOUN
admet-31	142	11	,	,	PUNCT
admet-31	142	12	the	the	DET
admet-31	142	13	relationship	relationship	NOUN
admet-31	142	14	between	between	ADP
admet-31	142	15	the	the	DET
admet-31	142	16	ksp	ksp	PROPN
admet-31	142	17	and	and	CCONJ
admet-31	142	18	s0	s0	PROPN
admet-31	142	19	can	can	AUX
admet-31	142	20	be	be	AUX
admet-31	142	21	dependent	dependent	ADJ
admet-31	142	22	on	on	ADP
admet-31	142	23	the	the	DET
admet-31	142	24	aggregation	aggregation	NOUN
admet-31	142	25	model	model	NOUN
admet-31	142	26	.	.	PUNCT
admet-31	143	1	it	it	PRON
admet-31	143	2	will	will	AUX
admet-31	143	3	be	be	AUX
admet-31	143	4	suggested	suggest	VERB
admet-31	143	5	below	below	ADP
admet-31	143	6	that	that	SCONJ
admet-31	143	7	it	it	PRON
admet-31	143	8	may	may	AUX
admet-31	143	9	be	be	AUX
admet-31	143	10	more	more	ADV
admet-31	143	11	meaningful	meaningful	ADJ
admet-31	143	12	to	to	PART
admet-31	143	13	assume	assume	VERB
admet-31	143	14	that	that	SCONJ
admet-31	143	15	the	the	DET
admet-31	143	16	data	datum	NOUN
admet-31	143	17	in	in	ADP
admet-31	143	18	the	the	DET
admet-31	143	19	deviation	deviation	NOUN
admet-31	143	20	region	region	NOUN
admet-31	143	21	ph	ph	VERB
admet-31	143	22	6	6	NUM
admet-31	143	23	-	-	SYM
admet-31	143	24	7	7	NUM
admet-31	143	25	is	be	AUX
admet-31	143	26	not	not	PART
admet-31	143	27	at	at	ADP
admet-31	143	28	equilibrium	equilibrium	NOUN
admet-31	143	29	.	.	PUNCT
admet-31	144	1	when	when	SCONJ
admet-31	144	2	the	the	DET
admet-31	144	3	data	datum	NOUN
admet-31	144	4	are	be	AUX
admet-31	144	5	excluded	exclude	VERB
admet-31	144	6	from	from	ADP
admet-31	144	7	the	the	DET
admet-31	144	8	analysis	analysis	NOUN
admet-31	144	9	and	and	CCONJ
admet-31	144	10	no	no	DET
admet-31	144	11	stable	stable	ADJ
admet-31	144	12	aggregate	aggregate	NOUN
admet-31	144	13	is	be	AUX
admet-31	144	14	assumed	assume	VERB
admet-31	144	15	present	present	ADJ
admet-31	144	16	,	,	PUNCT
admet-31	144	17	then	then	ADV
admet-31	144	18	pksp,1:1	pksp,1:1	X
admet-31	144	19	analyzes	analyze	VERB
admet-31	144	20	as	as	ADP
admet-31	144	21	2.74	2.74	NUM
admet-31	144	22	±	±	NUM
admet-31	144	23	0.04	0.04	NUM
admet-31	144	24	.	.	PUNCT
admet-31	145	1	the	the	DET
admet-31	145	2	latter	latter	ADJ
admet-31	145	3	value	value	NOUN
admet-31	145	4	,	,	PUNCT
admet-31	145	5	which	which	PRON
admet-31	145	6	follows	follow	VERB
admet-31	145	7	the	the	DET
admet-31	145	8	relationship	relationship	NOUN
admet-31	145	9	in	in	ADP
admet-31	145	10	figure	figure	NOUN
admet-31	145	11	8a	8a	NUM
admet-31	145	12	more	more	ADV
admet-31	145	13	closely	closely	ADV
admet-31	145	14	,	,	PUNCT
admet-31	145	15	was	be	AUX
admet-31	145	16	used	use	VERB
admet-31	145	17	in	in	ADP
admet-31	145	18	the	the	DET
admet-31	145	19	plot	plot	NOUN
admet-31	145	20	and	and	CCONJ
admet-31	145	21	regression	regression	VERB
admet-31	145	22	analysis	analysis	NOUN
admet-31	145	23	.	.	PUNCT
admet-31	146	1	case	case	NOUN
admet-31	146	2	3b	3b	NUM
admet-31	146	3	–	–	PUNCT
admet-31	146	4	mixed	mixed	ADJ
admet-31	146	5	-	-	PUNCT
admet-31	146	6	charge	charge	NOUN
admet-31	146	7	cationic	cationic	ADJ
admet-31	146	8	dimers	dimer	NOUN
admet-31	146	9	;	;	PUNCT
admet-31	146	10	henderson	henderson	PROPN
admet-31	146	11	-	-	PUNCT
admet-31	146	12	hasselbalch	hasselbalch	PROPN
admet-31	146	13	equation	equation	NOUN
admet-31	146	14	not	not	PART
admet-31	146	15	accurate	accurate	ADJ
admet-31	146	16	figure	figure	NOUN
admet-31	146	17	5	5	NUM
admet-31	146	18	shows	show	VERB
admet-31	146	19	four	four	NUM
admet-31	146	20	examples	example	NOUN
admet-31	146	21	of	of	ADP
admet-31	146	22	case	case	NOUN
admet-31	146	23	3b	3b	NUM
admet-31	146	24	log	log	NOUN
admet-31	146	25	s	s	PART
admet-31	146	26	–	–	PUNCT
admet-31	146	27	ph	ph	ADJ
admet-31	146	28	profiles	profile	NOUN
admet-31	146	29	.	.	PUNCT
admet-31	147	1	these	these	PRON
admet-31	147	2	are	be	AUX
admet-31	147	3	characterized	characterize	VERB
admet-31	147	4	by	by	ADP
admet-31	147	5	the	the	DET
admet-31	147	6	(	(	PUNCT
admet-31	147	7	slope	slope	NOUN
admet-31	147	8	=	=	SYM
admet-31	147	9	-1	-1	ADJ
admet-31	147	10	)	)	PUNCT
admet-31	147	11	diagonal	diagonal	ADJ
admet-31	147	12	region	region	NOUN
admet-31	147	13	of	of	ADP
admet-31	147	14	the	the	DET
admet-31	147	15	log	log	NOUN
admet-31	147	16	s	s	PART
admet-31	147	17	–	–	PUNCT
admet-31	147	18	ph	ph	ADJ
admet-31	147	19	profile	profile	NOUN
admet-31	147	20	shifted	shift	VERB
admet-31	147	21	to	to	ADP
admet-31	147	22	higher	high	ADJ
admet-31	147	23	ph	ph	NOUN
admet-31	147	24	(	(	PUNCT
admet-31	147	25	i.e.	i.e.	X
admet-31	147	26	,	,	PUNCT
admet-31	147	27	apparent	apparent	ADJ
admet-31	147	28	pka	pka	PROPN
admet-31	147	29	>	>	X
admet-31	147	30	true	true	ADJ
admet-31	147	31	pka	pka	PROPN
admet-31	147	32	)	)	PUNCT
admet-31	147	33	than	than	SCONJ
admet-31	147	34	predicted	predict	VERB
admet-31	147	35	by	by	ADP
admet-31	147	36	henderson	henderson	PROPN
admet-31	147	37	-	-	PUNCT
admet-31	147	38	hasselbalch	hasselbalch	PROPN
admet-31	147	39	equation	equation	NOUN
admet-31	147	40	,	,	PUNCT
admet-31	147	41	indicative	indicative	ADJ
admet-31	147	42	of	of	ADP
admet-31	147	43	mixed	mixed	ADJ
admet-31	147	44	-	-	PUNCT
admet-31	147	45	charge	charge	NOUN
admet-31	147	46	dimeric	dimeric	ADJ
admet-31	147	47	aggregates	aggregate	NOUN
admet-31	147	48	,	,	PUNCT
admet-31	147	49	bhb+	bhb+	PROPN
admet-31	147	50	.	.	PUNCT
admet-31	148	1	in	in	ADP
admet-31	148	2	such	such	ADJ
admet-31	148	3	cases	case	NOUN
admet-31	148	4	,	,	PUNCT
admet-31	148	5	the	the	DET
admet-31	148	6	apparent	apparent	ADJ
admet-31	148	7	s0	s0	NOUN
admet-31	148	8	is	be	AUX
admet-31	148	9	the	the	DET
admet-31	148	10	same	same	ADJ
admet-31	148	11	as	as	ADP
admet-31	148	12	the	the	DET
admet-31	148	13	true	true	ADJ
admet-31	148	14	s0	s0	PROPN
admet-31	148	15	.	.	PUNCT
admet-31	149	1	the	the	DET
admet-31	149	2	compounds	compound	NOUN
admet-31	149	3	are	be	AUX
admet-31	149	4	arranged	arrange	VERB
admet-31	149	5	in	in	ADP
admet-31	149	6	the	the	DET
admet-31	149	7	order	order	NOUN
admet-31	149	8	of	of	ADP
admet-31	149	9	increasing	increase	VERB
admet-31	149	10	dimerization	dimerization	NOUN
admet-31	149	11	formation	formation	NOUN
admet-31	149	12	constant	constant	ADJ
admet-31	149	13	,	,	PUNCT
admet-31	149	14	with	with	ADP
admet-31	149	15	trimethoprim	trimethoprim	NOUN
admet-31	149	16	nearly	nearly	ADV
admet-31	149	17	showing	show	VERB
admet-31	149	18	henderson	henderson	PROPN
admet-31	149	19	-	-	PUNCT
admet-31	149	20	hasselbalch	hasselbalch	NOUN
admet-31	149	21	characteristic	characteristic	NOUN
admet-31	149	22	of	of	ADP
admet-31	149	23	case	case	NOUN
admet-31	149	24	0	0	NUM
admet-31	149	25	.	.	PUNCT
admet-31	150	1	mifepristone	mifepristone	PROPN
admet-31	150	2	appears	appear	VERB
admet-31	150	3	to	to	PART
admet-31	150	4	admet	admet	PROPN
admet-31	150	5	&	&	CCONJ
admet-31	150	6	dmpk	dmpk	PROPN
admet-31	150	7	2(1	2(1	NUM
admet-31	150	8	)	)	PUNCT
admet-31	150	9	(	(	PUNCT
admet-31	150	10	2014	2014	NUM
admet-31	150	11	)	)	PUNCT
admet-31	150	12	43	43	NUM
admet-31	150	13	-	-	SYM
admet-31	150	14	55	55	NUM
admet-31	150	15	phosphate	phosphate	NOUN
admet-31	150	16	precipitates	precipitate	NOUN
admet-31	150	17	&	&	CCONJ
admet-31	150	18	aggregates	aggregate	NOUN
admet-31	150	19	of	of	ADP
admet-31	150	20	basic	basic	ADJ
admet-31	150	21	drugs	drug	NOUN
admet-31	150	22	doi	doi	NOUN
admet-31	150	23	:	:	PUNCT
admet-31	150	24	10.5599	10.5599	NUM
admet-31	150	25	/	/	SYM
admet-31	150	26	admet.2.1.31	admet.2.1.31	PROPN
admet-31	150	27	51	51	NUM
admet-31	150	28	show	show	VERB
admet-31	150	29	a	a	DET
admet-31	150	30	phosphate	phosphate	ADJ
admet-31	150	31	salt	salt	NOUN
admet-31	150	32	formation	formation	NOUN
admet-31	150	33	stoichiometry	stoichiometry	NOUN
admet-31	150	34	(	(	PUNCT
admet-31	150	35	bhb	bhb	ADJ
admet-31	150	36	+	+	CCONJ
admet-31	150	37	)	)	PUNCT
admet-31	150	38	∙b∙(h2po4	∙b∙(h2po4	NOUN
admet-31	150	39	)	)	PUNCT
admet-31	150	40	(	(	PUNCT
admet-31	150	41	s	s	NOUN
admet-31	150	42	)	)	PUNCT
admet-31	150	43	,	,	PUNCT
admet-31	150	44	characterized	characterize	VERB
admet-31	150	45	by	by	ADP
admet-31	150	46	an	an	DET
admet-31	150	47	average	average	ADJ
admet-31	150	48	slope	slope	NOUN
admet-31	150	49	-0.53	-0.53	NOUN
admet-31	150	50	±	±	NUM
admet-31	150	51	0.06	0.06	NUM
admet-31	150	52	in	in	ADP
admet-31	150	53	the	the	DET
admet-31	150	54	ph	ph	ADJ
admet-31	150	55	1.0	1.0	NUM
admet-31	150	56	–	–	PUNCT
admet-31	150	57	3.4	3.4	NUM
admet-31	150	58	salt	salt	NOUN
admet-31	150	59	region	region	NOUN
admet-31	150	60	,	,	PUNCT
admet-31	150	61	similar	similar	ADJ
admet-31	150	62	to	to	ADP
admet-31	150	63	the	the	DET
admet-31	150	64	case	case	NOUN
admet-31	150	65	of	of	ADP
admet-31	150	66	verapamil	verapamil	NOUN
admet-31	150	67	(	(	PUNCT
admet-31	150	68	fig	fig	NOUN
admet-31	150	69	.	.	PUNCT
admet-31	151	1	2c	2c	NUM
admet-31	151	2	)	)	PUNCT
admet-31	151	3	.	.	PUNCT
admet-31	152	1	trimethoprim	trimethoprim	PROPN
admet-31	152	2	and	and	CCONJ
admet-31	152	3	promethazine.hcl	promethazine.hcl	PRON
admet-31	152	4	show	show	VERB
admet-31	152	5	simple	simple	ADJ
admet-31	152	6	1:1	1:1	NUM
admet-31	152	7	and	and	CCONJ
admet-31	152	8	2:1	2:1	NUM
admet-31	152	9	phosphate	phosphate	ADJ
admet-31	152	10	salts	salt	NOUN
admet-31	152	11	.	.	PUNCT
admet-31	153	1	figure	figure	VERB
admet-31	153	2	5	5	NUM
admet-31	153	3	.	.	PUNCT
admet-31	154	1	case	case	NOUN
admet-31	154	2	3b	3b	NUM
admet-31	154	3	compounds	compound	NOUN
admet-31	154	4	which	which	PRON
admet-31	154	5	show	show	VERB
admet-31	154	6	log	log	NOUN
admet-31	154	7	s	s	PART
admet-31	154	8	–	–	PUNCT
admet-31	154	9	ph	ph	ADJ
admet-31	154	10	curve	curve	NOUN
admet-31	154	11	distortions	distortion	NOUN
admet-31	154	12	consistent	consistent	ADJ
admet-31	154	13	with	with	ADP
admet-31	154	14	the	the	DET
admet-31	154	15	formation	formation	NOUN
admet-31	154	16	of	of	ADP
admet-31	154	17	mixed	mixed	ADJ
admet-31	154	18	-	-	PUNCT
admet-31	154	19	charge	charge	NOUN
admet-31	154	20	dimeric	dimeric	ADJ
admet-31	154	21	aggregates	aggregate	NOUN
admet-31	154	22	.	.	PUNCT
admet-31	155	1	mixtures	mixture	NOUN
admet-31	155	2	of	of	ADP
admet-31	155	3	cases	case	NOUN
admet-31	155	4	;	;	PUNCT
admet-31	155	5	henderson	henderson	PROPN
admet-31	155	6	-	-	PUNCT
admet-31	155	7	hasselbalch	hasselbalch	PROPN
admet-31	155	8	equation	equation	NOUN
admet-31	155	9	not	not	PART
admet-31	155	10	accurate	accurate	ADJ
admet-31	155	11	figures	figure	NOUN
admet-31	155	12	6	6	NUM
admet-31	155	13	and	and	CCONJ
admet-31	155	14	7	7	NUM
admet-31	155	15	show	show	VERB
admet-31	155	16	examples	example	NOUN
admet-31	155	17	of	of	ADP
admet-31	155	18	mixtures	mixture	NOUN
admet-31	155	19	of	of	ADP
admet-31	155	20	case	case	NOUN
admet-31	155	21	1b+2b	1b+2b	NUM
admet-31	155	22	and	and	CCONJ
admet-31	155	23	2b+3b	2b+3b	NUM
admet-31	155	24	,	,	PUNCT
admet-31	155	25	respectively	respectively	ADV
admet-31	155	26	.	.	PUNCT
admet-31	156	1	the	the	DET
admet-31	156	2	case	case	NOUN
admet-31	156	3	1b	1b	NUM
admet-31	156	4	distortion	distortion	NOUN
admet-31	156	5	in	in	ADP
admet-31	156	6	thioridazine	thioridazine	PROPN
admet-31	156	7	may	may	AUX
admet-31	156	8	be	be	AUX
admet-31	156	9	due	due	ADJ
admet-31	156	10	to	to	ADP
admet-31	156	11	incomplete	incomplete	ADJ
admet-31	156	12	equilibration	equilibration	NOUN
admet-31	156	13	time	time	NOUN
admet-31	156	14	.	.	PUNCT
admet-31	157	1	figure	figure	VERB
admet-31	157	2	6	6	NUM
admet-31	157	3	.	.	PUNCT
admet-31	158	1	two	two	NUM
admet-31	158	2	examples	example	NOUN
admet-31	158	3	of	of	ADP
admet-31	158	4	compounds	compound	NOUN
admet-31	158	5	showing	show	VERB
admet-31	158	6	two	two	NUM
admet-31	158	7	overlapping	overlap	VERB
admet-31	158	8	distortion	distortion	NOUN
admet-31	158	9	types	type	NOUN
admet-31	158	10	:	:	PUNCT
admet-31	158	11	case	case	NOUN
admet-31	158	12	1b	1b	NUM
admet-31	158	13	(	(	PUNCT
admet-31	158	14	neutral	neutral	ADJ
admet-31	158	15	aggregates	aggregate	NOUN
admet-31	158	16	)	)	PUNCT
admet-31	158	17	and	and	CCONJ
admet-31	158	18	case	case	NOUN
admet-31	158	19	2b	2b	NUM
admet-31	158	20	(	(	PUNCT
admet-31	158	21	cationic	cationic	ADJ
admet-31	158	22	aggregates	aggregate	NOUN
admet-31	158	23	)	)	PUNCT
admet-31	158	24	.	.	PUNCT
admet-31	159	1	avdeef	avdeef	PROPN
admet-31	159	2	admet	admet	PROPN
admet-31	159	3	&	&	CCONJ
admet-31	159	4	dmpk	dmpk	PROPN
admet-31	159	5	2(1	2(1	NUM
admet-31	159	6	)	)	PUNCT
admet-31	159	7	(	(	PUNCT
admet-31	159	8	2014	2014	NUM
admet-31	159	9	)	)	PUNCT
admet-31	159	10	43	43	NUM
admet-31	159	11	-	-	SYM
admet-31	159	12	55	55	NUM
admet-31	159	13	52	52	NUM
admet-31	159	14	figure	figure	NOUN
admet-31	159	15	7	7	NUM
admet-31	159	16	.	.	NOUN
admet-31	160	1	three	three	NUM
admet-31	160	2	examples	example	NOUN
admet-31	160	3	of	of	ADP
admet-31	160	4	compounds	compound	NOUN
admet-31	160	5	showing	show	VERB
admet-31	160	6	two	two	NUM
admet-31	160	7	overlapping	overlap	VERB
admet-31	160	8	distortion	distortion	NOUN
admet-31	160	9	types	type	NOUN
admet-31	160	10	:	:	PUNCT
admet-31	160	11	case	case	NOUN
admet-31	160	12	2b	2b	NUM
admet-31	160	13	(	(	PUNCT
admet-31	160	14	cationic	cationic	ADJ
admet-31	160	15	aggregates	aggregate	NOUN
admet-31	160	16	)	)	PUNCT
admet-31	160	17	and	and	CCONJ
admet-31	160	18	case	case	NOUN
admet-31	160	19	3b	3b	NUM
admet-31	160	20	(	(	PUNCT
admet-31	160	21	mixed	mix	VERB
admet-31	160	22	-	-	PUNCT
admet-31	160	23	charge	charge	NOUN
admet-31	160	24	dimers	dimer	NOUN
admet-31	160	25	)	)	PUNCT
admet-31	160	26	.	.	PUNCT
admet-31	161	1	relationships	relationship	NOUN
admet-31	161	2	between	between	ADP
admet-31	161	3	intrinsic	intrinsic	ADJ
admet-31	161	4	solubility	solubility	NOUN
admet-31	161	5	and	and	CCONJ
admet-31	161	6	the	the	DET
admet-31	161	7	two	two	NUM
admet-31	161	8	phosphate	phosphate	NOUN
admet-31	161	9	solubility	solubility	NOUN
admet-31	161	10	products	product	NOUN
admet-31	161	11	relationship	relationship	NOUN
admet-31	161	12	between	between	ADP
admet-31	161	13	pksp,1:1	pksp,1:1	NOUN
admet-31	162	1	and	and	CCONJ
admet-31	162	2	ps0	ps0	VERB
admet-31	162	3	just	just	ADV
admet-31	162	4	18	18	NUM
admet-31	162	5	of	of	ADP
admet-31	162	6	the	the	DET
admet-31	162	7	25	25	NUM
admet-31	162	8	drugs	drug	NOUN
admet-31	162	9	considered	consider	VERB
admet-31	162	10	were	be	AUX
admet-31	162	11	interpreted	interpret	VERB
admet-31	162	12	to	to	PART
admet-31	162	13	include	include	VERB
admet-31	162	14	1:1	1:1	NUM
admet-31	162	15	bh∙h2po4	bh∙h2po4	ADJ
admet-31	162	16	salt	salt	NOUN
admet-31	162	17	formations	formation	NOUN
admet-31	162	18	.	.	PUNCT
admet-31	163	1	the	the	DET
admet-31	163	2	other	other	ADJ
admet-31	163	3	seven	seven	NUM
admet-31	163	4	drugs	drug	NOUN
admet-31	163	5	were	be	AUX
admet-31	163	6	either	either	CCONJ
admet-31	163	7	salts	salt	NOUN
admet-31	163	8	with	with	ADP
admet-31	163	9	complicated	complicated	ADJ
admet-31	163	10	phosphate	phosphate	ADJ
admet-31	163	11	stoichiometry	stoichiometry	NOUN
admet-31	163	12	or	or	CCONJ
admet-31	163	13	chloride	chloride	NOUN
admet-31	163	14	salts	salt	NOUN
admet-31	163	15	(	(	PUNCT
admet-31	163	16	for	for	ADP
admet-31	163	17	very	very	ADV
admet-31	163	18	soluble	soluble	ADJ
admet-31	163	19	drugs	drug	NOUN
admet-31	163	20	introduced	introduce	VERB
admet-31	163	21	as	as	ADP
admet-31	163	22	hydrochlorides	hydrochloride	NOUN
admet-31	163	23	)	)	PUNCT
admet-31	163	24	.	.	PUNCT
admet-31	164	1	the	the	DET
admet-31	164	2	average	average	NOUN
admet-31	164	3	of	of	ADP
admet-31	164	4	the	the	DET
admet-31	164	5	ratio	ratio	NOUN
admet-31	164	6	values	value	NOUN
admet-31	164	7	pksp,1:1	pksp,1:1	X
admet-31	164	8	/	/	PUNCT
admet-31	164	9	ps0	ps0	NOUN
admet-31	164	10	is	be	AUX
admet-31	164	11	0.73	0.73	NUM
admet-31	164	12	±	±	NUM
admet-31	164	13	0.34	0.34	NUM
admet-31	164	14	.	.	PUNCT
admet-31	165	1	figure	figure	NOUN
admet-31	165	2	8a	8a	PROPN
admet-31	165	3	shows	show	VERB
admet-31	165	4	the	the	DET
admet-31	165	5	empirical	empirical	ADJ
admet-31	165	6	correlation	correlation	NOUN
admet-31	165	7	between	between	ADP
admet-31	165	8	the	the	DET
admet-31	165	9	pksp,1:1	pksp,1:1	PROPN
admet-31	165	10	constant	constant	ADJ
admet-31	165	11	and	and	CCONJ
admet-31	165	12	the	the	DET
admet-31	165	13	intrinsic	intrinsic	ADJ
admet-31	165	14	solubility	solubility	NOUN
admet-31	165	15	ps0	ps0	NOUN
admet-31	165	16	for	for	ADP
admet-31	165	17	the	the	DET
admet-31	165	18	18	18	NUM
admet-31	165	19	compounds	compound	NOUN
admet-31	165	20	.	.	PUNCT
admet-31	166	1	a	a	DET
admet-31	166	2	trend	trend	NOUN
admet-31	166	3	is	be	AUX
admet-31	166	4	evident	evident	ADJ
admet-31	166	5	,	,	PUNCT
admet-31	166	6	in	in	ADP
admet-31	166	7	that	that	SCONJ
admet-31	166	8	the	the	DET
admet-31	166	9	less	less	ADV
admet-31	166	10	soluble	soluble	ADJ
admet-31	166	11	the	the	DET
admet-31	166	12	uncharged	uncharged	ADJ
admet-31	166	13	form	form	NOUN
admet-31	166	14	of	of	ADP
admet-31	166	15	the	the	DET
admet-31	166	16	drug	drug	NOUN
admet-31	166	17	,	,	PUNCT
admet-31	166	18	the	the	DET
admet-31	166	19	lower	low	ADJ
admet-31	166	20	is	be	AUX
admet-31	166	21	the	the	DET
admet-31	166	22	ksp	ksp	PROPN
admet-31	166	23	value	value	NOUN
admet-31	166	24	.	.	PUNCT
admet-31	167	1	although	although	SCONJ
admet-31	167	2	the	the	DET
admet-31	167	3	variance	variance	NOUN
admet-31	167	4	is	be	AUX
admet-31	167	5	relatively	relatively	ADV
admet-31	167	6	large	large	ADJ
admet-31	167	7	,	,	PUNCT
admet-31	167	8	the	the	DET
admet-31	167	9	relationship	relationship	NOUN
admet-31	167	10	can	can	AUX
admet-31	167	11	still	still	ADV
admet-31	167	12	be	be	AUX
admet-31	167	13	a	a	DET
admet-31	167	14	valuable	valuable	ADJ
admet-31	167	15	basis	basis	NOUN
admet-31	167	16	for	for	ADP
admet-31	167	17	prediction	prediction	NOUN
admet-31	167	18	of	of	ADP
admet-31	167	19	the	the	DET
admet-31	167	20	phosphate	phosphate	NOUN
admet-31	167	21	solubility	solubility	NOUN
admet-31	167	22	product	product	NOUN
admet-31	167	23	in	in	ADP
admet-31	167	24	the	the	DET
admet-31	167	25	absence	absence	NOUN
admet-31	167	26	of	of	ADP
admet-31	167	27	measurement	measurement	NOUN
admet-31	167	28	.	.	PUNCT
admet-31	168	1	figure	figure	NOUN
admet-31	168	2	8	8	NUM
admet-31	168	3	.	.	PUNCT
admet-31	169	1	(	(	PUNCT
admet-31	169	2	a	a	X
admet-31	169	3	)	)	PUNCT
admet-31	169	4	correlations	correlation	NOUN
admet-31	169	5	between	between	ADP
admet-31	169	6	the	the	DET
admet-31	169	7	1:1	1:1	NUM
admet-31	169	8	salt	salt	NOUN
admet-31	169	9	solubility	solubility	NOUN
admet-31	169	10	products	product	NOUN
admet-31	169	11	and	and	CCONJ
admet-31	169	12	the	the	DET
admet-31	169	13	intrinsic	intrinsic	ADJ
admet-31	169	14	solubility	solubility	NOUN
admet-31	169	15	constants	constant	NOUN
admet-31	169	16	for	for	ADP
admet-31	169	17	18	18	NUM
admet-31	169	18	of	of	ADP
admet-31	169	19	the	the	DET
admet-31	169	20	studied	study	VERB
admet-31	169	21	compounds	compound	NOUN
admet-31	169	22	.	.	PUNCT
admet-31	170	1	(	(	PUNCT
admet-31	170	2	b	b	X
admet-31	170	3	)	)	PUNCT
admet-31	170	4	correlation	correlation	NOUN
admet-31	170	5	between	between	ADP
admet-31	170	6	1:1	1:1	NUM
admet-31	170	7	and	and	CCONJ
admet-31	170	8	2:1	2:1	NUM
admet-31	170	9	drug	drug	NOUN
admet-31	170	10	-	-	PUNCT
admet-31	170	11	phosphate	phosphate	NOUN
admet-31	170	12	solubility	solubility	NOUN
admet-31	170	13	products	product	NOUN
admet-31	170	14	for	for	ADP
admet-31	170	15	9	9	NUM
admet-31	170	16	of	of	ADP
admet-31	170	17	the	the	DET
admet-31	170	18	studied	study	VERB
admet-31	170	19	compounds	compound	NOUN
admet-31	170	20	.	.	PUNCT
admet-31	171	1	the	the	DET
admet-31	171	2	bracket	bracket	ADJ
admet-31	171	3	concentration	concentration	NOUN
admet-31	171	4	products	product	NOUN
admet-31	171	5	(	(	PUNCT
admet-31	171	6	molarity	molarity	NOUN
admet-31	171	7	related	relate	VERB
admet-31	171	8	units	unit	NOUN
admet-31	171	9	)	)	PUNCT
admet-31	171	10	in	in	ADP
admet-31	171	11	the	the	DET
admet-31	171	12	labels	label	NOUN
admet-31	171	13	have	have	VERB
admet-31	171	14	–	–	PUNCT
admet-31	171	15	log10	log10	PROPN
admet-31	171	16	implied	imply	VERB
admet-31	171	17	.	.	PUNCT
admet-31	172	1	relationship	relationship	NOUN
admet-31	172	2	between	between	ADP
admet-31	172	3	pksp,1:1	pksp,1:1	NOUN
admet-31	172	4	and	and	CCONJ
admet-31	172	5	pksp,2:1	pksp,2:1	CCONJ
admet-31	172	6	nine	nine	NUM
admet-31	172	7	of	of	ADP
admet-31	172	8	the	the	DET
admet-31	172	9	25	25	NUM
admet-31	172	10	drugs	drug	NOUN
admet-31	172	11	were	be	AUX
admet-31	172	12	interpreted	interpret	VERB
admet-31	172	13	to	to	PART
admet-31	172	14	have	have	VERB
admet-31	172	15	both	both	DET
admet-31	172	16	1:1	1:1	NUM
admet-31	172	17	and	and	CCONJ
admet-31	172	18	2:1	2:1	NUM
admet-31	172	19	phosphate	phosphate	ADJ
admet-31	172	20	salt	salt	NOUN
admet-31	172	21	precipitation	precipitation	NOUN
admet-31	172	22	.	.	PUNCT
admet-31	173	1	figure	figure	VERB
admet-31	173	2	8b	8b	PROPN
admet-31	173	3	shows	show	VERB
admet-31	173	4	an	an	DET
admet-31	173	5	extraordinarily	extraordinarily	ADV
admet-31	173	6	high	high	ADJ
admet-31	173	7	correlation	correlation	NOUN
admet-31	173	8	between	between	ADP
admet-31	173	9	the	the	DET
admet-31	173	10	two	two	NUM
admet-31	173	11	salt	salt	NOUN
admet-31	173	12	solubility	solubility	NOUN
admet-31	173	13	products	product	NOUN
admet-31	173	14	.	.	PUNCT
admet-31	174	1	this	this	PRON
admet-31	174	2	is	be	AUX
admet-31	174	3	probably	probably	ADV
admet-31	174	4	expected	expect	VERB
admet-31	174	5	from	from	ADP
admet-31	174	6	equilibrium	equilibrium	NOUN
admet-31	174	7	equation	equation	NOUN
admet-31	174	8	considerations	consideration	NOUN
admet-31	174	9	,	,	PUNCT
admet-31	174	10	since	since	SCONJ
admet-31	174	11	the	the	DET
admet-31	174	12	slope	slope	NOUN
admet-31	174	13	of	of	ADP
admet-31	174	14	0.46	0.46	NUM
admet-31	174	15	is	be	AUX
admet-31	174	16	so	so	ADV
admet-31	174	17	close	close	ADJ
admet-31	174	18	to	to	ADP
admet-31	174	19	the	the	DET
admet-31	174	20	one	one	NUM
admet-31	174	21	-	-	PUNCT
admet-31	174	22	to	to	ADP
admet-31	174	23	-	-	PUNCT
admet-31	174	24	two	two	NUM
admet-31	174	25	ratio	ratio	NOUN
admet-31	174	26	of	of	ADP
admet-31	174	27	stoichiometries	stoichiometry	NOUN
admet-31	174	28	.	.	PUNCT
admet-31	175	1	the	the	DET
admet-31	175	2	average	average	ADJ
admet-31	175	3	ratio	ratio	NOUN
admet-31	175	4	of	of	ADP
admet-31	175	5	the	the	DET
admet-31	175	6	two	two	NUM
admet-31	175	7	pksp	pksp	ADJ
admet-31	175	8	constants	constant	NOUN
admet-31	175	9	is	be	AUX
admet-31	175	10	0.50	0.50	NUM
admet-31	175	11	±	±	NUM
admet-31	175	12	0.04	0.04	NUM
admet-31	175	13	in	in	ADP
admet-31	175	14	figure	figure	NOUN
admet-31	175	15	8b	8b	NUM
admet-31	175	16	.	.	PUNCT
admet-31	176	1	admet	admet	PROPN
admet-31	176	2	&	&	CCONJ
admet-31	176	3	dmpk	dmpk	PROPN
admet-31	176	4	2(1	2(1	NUM
admet-31	176	5	)	)	PUNCT
admet-31	176	6	(	(	PUNCT
admet-31	176	7	2014	2014	NUM
admet-31	176	8	)	)	PUNCT
admet-31	176	9	43	43	NUM
admet-31	176	10	-	-	SYM
admet-31	176	11	55	55	NUM
admet-31	176	12	phosphate	phosphate	NOUN
admet-31	176	13	precipitates	precipitate	NOUN
admet-31	176	14	&	&	CCONJ
admet-31	176	15	aggregates	aggregate	NOUN
admet-31	176	16	of	of	ADP
admet-31	176	17	basic	basic	ADJ
admet-31	176	18	drugs	drug	NOUN
admet-31	176	19	doi	doi	NOUN
admet-31	176	20	:	:	PUNCT
admet-31	176	21	10.5599	10.5599	NUM
admet-31	176	22	/	/	SYM
admet-31	176	23	admet.2.1.31	admet.2.1.31	PROPN
admet-31	176	24	53	53	NUM
admet-31	176	25	prediction	prediction	NOUN
admet-31	176	26	equations	equation	NOUN
admet-31	176	27	for	for	ADP
admet-31	176	28	phosphate	phosphate	ADJ
admet-31	176	29	salts	salt	NOUN
admet-31	176	30	from	from	ADP
admet-31	176	31	the	the	DET
admet-31	176	32	correlation	correlation	NOUN
admet-31	176	33	relationships	relationship	NOUN
admet-31	176	34	in	in	ADP
admet-31	176	35	figure	figure	NOUN
admet-31	176	36	8	8	NUM
admet-31	176	37	,	,	PUNCT
admet-31	176	38	two	two	NUM
admet-31	176	39	useful	useful	ADJ
admet-31	176	40	empirical	empirical	ADJ
admet-31	176	41	equations	equation	NOUN
admet-31	176	42	may	may	AUX
admet-31	176	43	be	be	AUX
admet-31	176	44	derived	derive	VERB
admet-31	176	45	:	:	PUNCT
admet-31	176	46	pksp,1:1	pksp,1:1	ADJ
admet-31	177	1	=	=	PUNCT
admet-31	177	2	0.525	0.525	NUM
admet-31	177	3	+	+	CCONJ
admet-31	177	4	0.554	0.554	NUM
admet-31	177	5	ps0	ps0	ADJ
admet-31	177	6	(	(	PUNCT
admet-31	177	7	1	1	NUM
admet-31	177	8	)	)	PUNCT
admet-31	177	9	pksp,2:1	pksp,2:1	NOUN
admet-31	178	1	=	=	NOUN
admet-31	178	2	0.744	0.744	NUM
admet-31	179	1	+	+	NUM
admet-31	179	2	1.207	1.207	NUM
admet-31	179	3	ps0	ps0	NOUN
admet-31	179	4	=	=	SYM
admet-31	179	5	-0.4002	-0.4002	NOUN
admet-31	179	6	+2.1796	+2.1796	X
admet-31	179	7	pksp,1:1	pksp,1:1	PROPN
admet-31	180	1	(	(	PUNCT
admet-31	180	2	2	2	X
admet-31	180	3	)	)	PUNCT
admet-31	180	4	these	these	DET
admet-31	180	5	equations	equation	NOUN
admet-31	180	6	were	be	AUX
admet-31	180	7	used	use	VERB
admet-31	180	8	to	to	PART
admet-31	180	9	fill	fill	VERB
admet-31	180	10	in	in	ADP
admet-31	180	11	the	the	DET
admet-31	180	12	“	"	PUNCT
admet-31	180	13	missing	missing	ADJ
admet-31	180	14	”	"	PUNCT
admet-31	180	15	values	value	NOUN
admet-31	180	16	in	in	ADP
admet-31	180	17	table	table	NOUN
admet-31	180	18	1	1	NUM
admet-31	180	19	,	,	PUNCT
admet-31	180	20	indicated	indicate	VERB
admet-31	180	21	in	in	ADP
admet-31	180	22	red	red	ADJ
admet-31	180	23	italic	italic	ADJ
admet-31	180	24	numbers	number	NOUN
admet-31	180	25	.	.	PUNCT
admet-31	181	1	chloride	chloride	NOUN
admet-31	181	2	salts	salt	NOUN
admet-31	181	3	since	since	SCONJ
admet-31	181	4	some	some	DET
admet-31	181	5	relatively	relatively	ADV
admet-31	181	6	soluble	soluble	ADJ
admet-31	181	7	salts	salt	NOUN
admet-31	181	8	were	be	AUX
admet-31	181	9	introduced	introduce	VERB
admet-31	181	10	as	as	ADP
admet-31	181	11	drug	drug	NOUN
admet-31	181	12	hydrochlorides	hydrochloride	NOUN
admet-31	181	13	,	,	PUNCT
admet-31	181	14	the	the	DET
admet-31	181	15	solubility	solubility	NOUN
admet-31	181	16	data	datum	NOUN
admet-31	181	17	were	be	AUX
admet-31	181	18	tested	test	VERB
admet-31	181	19	for	for	ADP
admet-31	181	20	the	the	DET
admet-31	181	21	possibility	possibility	NOUN
admet-31	181	22	of	of	ADP
admet-31	181	23	chloride	chloride	NOUN
admet-31	181	24	precipitates	precipitate	NOUN
admet-31	181	25	.	.	PUNCT
admet-31	182	1	the	the	DET
admet-31	182	2	log	log	NOUN
admet-31	182	3	s	s	PART
admet-31	182	4	–	–	PUNCT
admet-31	182	5	ph	ph	ADJ
admet-31	182	6	plots	plot	NOUN
admet-31	182	7	for	for	ADP
admet-31	182	8	celiprolol	celiprolol	NOUN
admet-31	182	9	,	,	PUNCT
admet-31	182	10	orphenadrine	orphenadrine	NOUN
admet-31	182	11	,	,	PUNCT
admet-31	182	12	terazosin	terazosin	NOUN
admet-31	182	13	and	and	CCONJ
admet-31	182	14	pramoxine	pramoxine	NOUN
admet-31	182	15	appeared	appear	VERB
admet-31	182	16	to	to	PART
admet-31	182	17	be	be	AUX
admet-31	182	18	consistent	consistent	ADJ
admet-31	182	19	with	with	ADP
admet-31	182	20	the	the	DET
admet-31	182	21	formation	formation	NOUN
admet-31	182	22	of	of	ADP
admet-31	182	23	1:1	1:1	NUM
admet-31	182	24	chloride	chloride	NOUN
admet-31	182	25	salts	salt	NOUN
admet-31	182	26	.	.	PUNCT
admet-31	183	1	the	the	DET
admet-31	183	2	salt	salt	NOUN
admet-31	183	3	region	region	NOUN
admet-31	183	4	in	in	ADP
admet-31	183	5	the	the	DET
admet-31	183	6	solubility	solubility	NOUN
admet-31	183	7	plot	plot	NOUN
admet-31	183	8	is	be	AUX
admet-31	183	9	expected	expect	VERB
admet-31	183	10	to	to	PART
admet-31	183	11	be	be	AUX
admet-31	183	12	a	a	DET
admet-31	183	13	horizontal	horizontal	ADJ
admet-31	183	14	line	line	NOUN
admet-31	183	15	,	,	PUNCT
admet-31	183	16	since	since	SCONJ
admet-31	183	17	the	the	DET
admet-31	183	18	common	common	ADJ
admet-31	183	19	ion	ion	NOUN
admet-31	183	20	effect	effect	NOUN
admet-31	183	21	is	be	AUX
admet-31	183	22	not	not	PART
admet-31	183	23	expected	expect	VERB
admet-31	183	24	when	when	SCONJ
admet-31	183	25	the	the	DET
admet-31	183	26	ph	ph	NOUN
admet-31	183	27	is	be	AUX
admet-31	183	28	adjusted	adjust	VERB
admet-31	183	29	using	use	VERB
admet-31	183	30	h3po4	h3po4	NOUN
admet-31	183	31	.	.	PUNCT
admet-31	184	1	however	however	ADV
admet-31	184	2	,	,	PUNCT
admet-31	184	3	the	the	DET
admet-31	184	4	above	above	ADJ
admet-31	184	5	assignments	assignment	NOUN
admet-31	184	6	are	be	AUX
admet-31	184	7	tentative	tentative	ADJ
admet-31	184	8	without	without	ADP
admet-31	184	9	additional	additional	ADJ
admet-31	184	10	data	datum	NOUN
admet-31	184	11	collected	collect	VERB
admet-31	184	12	at	at	ADP
admet-31	184	13	different	different	ADJ
admet-31	184	14	added	add	VERB
admet-31	184	15	amounts	amount	NOUN
admet-31	184	16	of	of	ADP
admet-31	184	17	these	these	DET
admet-31	184	18	drugs	drug	NOUN
admet-31	184	19	,	,	PUNCT
admet-31	184	20	especially	especially	ADV
admet-31	184	21	with	with	ADP
admet-31	184	22	data	datum	NOUN
admet-31	184	23	taken	take	VERB
admet-31	184	24	to	to	ADP
admet-31	184	25	very	very	ADV
admet-31	184	26	low	low	ADJ
admet-31	184	27	ph	ph	ADJ
admet-31	184	28	values	value	NOUN
admet-31	184	29	.	.	PUNCT
admet-31	185	1	how	how	SCONJ
admet-31	185	2	constant	constant	ADJ
admet-31	185	3	are	be	AUX
admet-31	185	4	solubility	solubility	NOUN
admet-31	185	5	products	product	NOUN
admet-31	185	6	?	?	PUNCT
admet-31	186	1	the	the	DET
admet-31	186	2	pdisol	pdisol	ADJ
admet-31	186	3	-	-	PUNCT
admet-31	186	4	x	x	NOUN
admet-31	186	5	program	program	NOUN
admet-31	186	6	calculates	calculate	VERB
admet-31	186	7	the	the	DET
admet-31	186	8	ionic	ionic	ADJ
admet-31	186	9	strength	strength	NOUN
admet-31	186	10	at	at	ADP
admet-31	186	11	each	each	DET
admet-31	186	12	ph	ph	ADJ
admet-31	186	13	point	point	NOUN
admet-31	186	14	in	in	ADP
admet-31	186	15	the	the	DET
admet-31	186	16	processing	processing	NOUN
admet-31	186	17	of	of	ADP
admet-31	186	18	the	the	DET
admet-31	186	19	log	log	NOUN
admet-31	186	20	s	s	PART
admet-31	186	21	–	–	PUNCT
admet-31	186	22	ph	ph	ADJ
admet-31	186	23	data	datum	NOUN
admet-31	186	24	,	,	PUNCT
admet-31	186	25	as	as	SCONJ
admet-31	186	26	described	describe	VERB
admet-31	186	27	in	in	ADP
admet-31	186	28	detail	detail	NOUN
admet-31	186	29	elsewhere	elsewhere	ADV
admet-31	186	30	[	[	X
admet-31	186	31	11	11	NUM
admet-31	186	32	]	]	PUNCT
admet-31	186	33	.	.	PUNCT
admet-31	187	1	figure	figure	NOUN
admet-31	187	2	9	9	NUM
admet-31	187	3	shows	show	VERB
admet-31	187	4	the	the	DET
admet-31	187	5	speciation	speciation	NOUN
admet-31	187	6	analysis	analysis	NOUN
admet-31	187	7	of	of	ADP
admet-31	187	8	disopyramide	disopyramide	NOUN
admet-31	187	9	in	in	ADP
admet-31	187	10	the	the	DET
admet-31	187	11	phosphate	phosphate	ADJ
admet-31	187	12	salt	salt	NOUN
admet-31	187	13	region	region	NOUN
admet-31	187	14	,	,	PUNCT
admet-31	187	15	ph	ph	X
admet-31	187	16	2	2	NUM
admet-31	187	17	–	–	PUNCT
admet-31	187	18	9	9	NUM
admet-31	187	19	.	.	X
admet-31	187	20	figure	figure	NOUN
admet-31	187	21	9b	9b	PROPN
admet-31	187	22	shows	show	VERB
admet-31	187	23	that	that	SCONJ
admet-31	187	24	the	the	DET
admet-31	187	25	ionic	ionic	ADJ
admet-31	187	26	strength	strength	NOUN
admet-31	187	27	varies	vary	VERB
admet-31	187	28	from	from	ADP
admet-31	187	29	about	about	ADV
admet-31	187	30	0.1	0.1	NUM
admet-31	187	31	to	to	PART
admet-31	187	32	0.4	0.4	NUM
admet-31	187	33	m	m	NOUN
admet-31	187	34	as	as	ADP
admet-31	187	35	the	the	DET
admet-31	187	36	ph	ph	ADJ
admet-31	187	37	changes	change	NOUN
admet-31	187	38	from	from	ADP
admet-31	187	39	2	2	NUM
admet-31	187	40	to	to	ADP
admet-31	187	41	9	9	NUM
admet-31	187	42	.	.	PUNCT
admet-31	188	1	the	the	DET
admet-31	188	2	vertical	vertical	ADJ
admet-31	188	3	dotted	dotted	ADJ
admet-31	188	4	line	line	NOUN
admet-31	188	5	near	near	ADP
admet-31	188	6	ph	ph	PROPN
admet-31	188	7	6	6	NUM
admet-31	188	8	in	in	ADP
admet-31	188	9	figure	figure	NOUN
admet-31	188	10	9a	9a	NOUN
admet-31	188	11	indicates	indicate	VERB
admet-31	188	12	the	the	DET
admet-31	188	13	transition	transition	NOUN
admet-31	188	14	ph	ph	NOUN
admet-31	188	15	between	between	ADP
admet-31	188	16	the	the	DET
admet-31	188	17	1:1	1:1	NUM
admet-31	188	18	and	and	CCONJ
admet-31	188	19	the	the	DET
admet-31	188	20	2:1	2:1	NUM
admet-31	188	21	phosphate	phosphate	ADJ
admet-31	188	22	salts	salt	NOUN
admet-31	188	23	.	.	PUNCT
admet-31	189	1	the	the	DET
admet-31	189	2	ionic	ionic	ADJ
admet-31	189	3	strength	strength	NOUN
admet-31	189	4	dependence	dependence	NOUN
admet-31	189	5	of	of	ADP
admet-31	189	6	the	the	DET
admet-31	189	7	two	two	NUM
admet-31	189	8	ksp	ksp	PROPN
admet-31	189	9	constants	constant	NOUN
admet-31	189	10	differs	differ	NOUN
admet-31	189	11	,	,	PUNCT
admet-31	189	12	which	which	PRON
admet-31	189	13	affects	affect	VERB
admet-31	189	14	the	the	DET
admet-31	189	15	calculated	calculated	ADJ
admet-31	189	16	concentrations	concentration	NOUN
admet-31	189	17	.	.	PUNCT
admet-31	190	1	the	the	DET
admet-31	190	2	result	result	NOUN
admet-31	190	3	of	of	ADP
admet-31	190	4	this	this	PRON
admet-31	190	5	is	be	AUX
admet-31	190	6	that	that	SCONJ
admet-31	190	7	the	the	DET
admet-31	190	8	solubility	solubility	NOUN
admet-31	190	9	product	product	NOUN
admet-31	190	10	above	above	ADP
admet-31	190	11	ph	ph	PROPN
admet-31	190	12	6	6	NUM
admet-31	190	13	is	be	AUX
admet-31	190	14	not	not	PART
admet-31	190	15	exactly	exactly	ADV
admet-31	190	16	constant	constant	ADJ
admet-31	190	17	,	,	PUNCT
admet-31	190	18	due	due	ADP
admet-31	190	19	to	to	ADP
admet-31	190	20	the	the	DET
admet-31	190	21	effect	effect	NOUN
admet-31	190	22	of	of	ADP
admet-31	190	23	ionic	ionic	ADJ
admet-31	190	24	strength	strength	NOUN
admet-31	190	25	.	.	PUNCT
admet-31	191	1	the	the	DET
admet-31	191	2	analysis	analysis	NOUN
admet-31	191	3	program	program	NOUN
admet-31	191	4	is	be	AUX
admet-31	191	5	particularly	particularly	ADV
admet-31	191	6	well	well	ADV
admet-31	191	7	suited	suited	ADJ
admet-31	191	8	to	to	PART
admet-31	191	9	explore	explore	VERB
admet-31	191	10	the	the	DET
admet-31	191	11	consequences	consequence	NOUN
admet-31	191	12	of	of	ADP
admet-31	191	13	the	the	DET
admet-31	191	14	choices	choice	NOUN
admet-31	191	15	of	of	ADP
admet-31	191	16	various	various	ADJ
admet-31	191	17	species	specie	NOUN
admet-31	191	18	tested	test	VERB
admet-31	191	19	in	in	ADP
admet-31	191	20	the	the	DET
admet-31	191	21	solubility	solubility	NOUN
admet-31	191	22	model	model	NOUN
admet-31	191	23	.	.	PUNCT
admet-31	192	1	avdeef	avdeef	PROPN
admet-31	192	2	admet	admet	PROPN
admet-31	192	3	&	&	CCONJ
admet-31	192	4	dmpk	dmpk	PROPN
admet-31	192	5	2(1	2(1	NUM
admet-31	192	6	)	)	PUNCT
admet-31	192	7	(	(	PUNCT
admet-31	192	8	2014	2014	NUM
admet-31	192	9	)	)	PUNCT
admet-31	192	10	43	43	NUM
admet-31	192	11	-	-	SYM
admet-31	192	12	55	55	NUM
admet-31	192	13	54	54	NUM
admet-31	192	14	figure	figure	NOUN
admet-31	192	15	9	9	NUM
admet-31	192	16	.	.	PUNCT
admet-31	193	1	the	the	DET
admet-31	193	2	effect	effect	NOUN
admet-31	193	3	of	of	ADP
admet-31	193	4	the	the	DET
admet-31	193	5	ionic	ionic	ADJ
admet-31	193	6	strength	strength	NOUN
admet-31	193	7	on	on	ADP
admet-31	193	8	the	the	DET
admet-31	193	9	constancy	constancy	NOUN
admet-31	193	10	of	of	ADP
admet-31	193	11	the	the	DET
admet-31	193	12	solubility	solubility	NOUN
admet-31	193	13	product	product	NOUN
admet-31	193	14	.	.	PUNCT
admet-31	194	1	conclusions	conclusion	NOUN
admet-31	194	2	evidently	evidently	ADV
admet-31	194	3	,	,	PUNCT
admet-31	194	4	concentrated	concentrated	ADJ
admet-31	194	5	phosphate	phosphate	NOUN
admet-31	194	6	buffers	buffer	NOUN
admet-31	194	7	(	(	PUNCT
admet-31	194	8	0.15	0.15	NUM
admet-31	194	9	m	m	VERB
admet-31	194	10	)	)	PUNCT
admet-31	194	11	can	can	AUX
admet-31	194	12	dramatically	dramatically	ADV
admet-31	194	13	influence	influence	VERB
admet-31	194	14	the	the	DET
admet-31	194	15	solubility	solubility	NOUN
admet-31	194	16	profiles	profile	NOUN
admet-31	194	17	of	of	ADP
admet-31	194	18	sparingly	sparingly	ADV
admet-31	194	19	soluble	soluble	ADJ
admet-31	194	20	drugs	drug	NOUN
admet-31	194	21	.	.	PUNCT
admet-31	195	1	clearly	clearly	ADV
admet-31	195	2	,	,	PUNCT
admet-31	195	3	the	the	DET
admet-31	195	4	bergström	bergström	NOUN
admet-31	195	5	et	et	PROPN
admet-31	195	6	al	al	PROPN
admet-31	195	7	.	.	PUNCT
admet-31	196	1	[	[	X
admet-31	196	2	13	13	NUM
admet-31	196	3	]	]	PUNCT
admet-31	196	4	data	datum	NOUN
admet-31	196	5	for	for	ADP
admet-31	196	6	the	the	DET
admet-31	196	7	25	25	NUM
admet-31	196	8	compounds	compound	NOUN
admet-31	196	9	studied	study	VERB
admet-31	196	10	could	could	AUX
admet-31	196	11	not	not	PART
admet-31	196	12	be	be	AUX
admet-31	196	13	explained	explain	VERB
admet-31	196	14	by	by	ADP
admet-31	196	15	the	the	DET
admet-31	196	16	simple	simple	ADJ
admet-31	196	17	henderson	henderson	PROPN
admet-31	196	18	-	-	PUNCT
admet-31	196	19	hasselbalch	hasselbalch	PROPN
admet-31	196	20	equation	equation	NOUN
admet-31	196	21	in	in	ADP
admet-31	196	22	all	all	PRON
admet-31	196	23	but	but	CCONJ
admet-31	196	24	six	six	NUM
admet-31	196	25	cases	case	NOUN
admet-31	196	26	.	.	PUNCT
admet-31	197	1	apparently	apparently	ADV
admet-31	197	2	,	,	PUNCT
admet-31	197	3	the	the	DET
admet-31	197	4	aggregated	aggregate	VERB
admet-31	197	5	species	specie	NOUN
admet-31	197	6	proposed	propose	VERB
admet-31	197	7	here	here	ADV
admet-31	197	8	were	be	AUX
admet-31	197	9	either	either	PRON
admet-31	197	10	not	not	PART
admet-31	197	11	recognized	recognize	VERB
admet-31	197	12	originally	originally	ADV
admet-31	197	13	,	,	PUNCT
admet-31	197	14	or	or	CCONJ
admet-31	197	15	were	be	AUX
admet-31	197	16	not	not	PART
admet-31	197	17	fully	fully	ADV
admet-31	197	18	explored	explore	VERB
admet-31	197	19	.	.	PUNCT
admet-31	198	1	such	such	ADJ
admet-31	198	2	anomalies	anomaly	NOUN
admet-31	198	3	may	may	AUX
admet-31	198	4	be	be	AUX
admet-31	198	5	common	common	ADJ
admet-31	198	6	with	with	ADP
admet-31	198	7	sparingly	sparingly	ADV
admet-31	198	8	soluble	soluble	ADJ
admet-31	198	9	drugs	drug	NOUN
admet-31	198	10	,	,	PUNCT
admet-31	198	11	but	but	CCONJ
admet-31	198	12	are	be	AUX
admet-31	198	13	not	not	PART
admet-31	198	14	always	always	ADV
admet-31	198	15	easy	easy	ADJ
admet-31	198	16	to	to	PART
admet-31	198	17	recognize	recognize	VERB
admet-31	198	18	.	.	PUNCT
admet-31	199	1	pdisol	pdisol	ADJ
admet-31	199	2	-	-	PUNCT
admet-31	199	3	x	x	PRON
admet-31	199	4	could	could	AUX
admet-31	199	5	be	be	AUX
admet-31	199	6	a	a	DET
admet-31	199	7	helpful	helpful	ADJ
admet-31	199	8	new	new	ADJ
admet-31	199	9	tool	tool	NOUN
admet-31	199	10	in	in	ADP
admet-31	199	11	early	early	ADJ
admet-31	199	12	development	development	NOUN
admet-31	199	13	to	to	PART
admet-31	199	14	further	further	ADJ
admet-31	199	15	aid	aid	NOUN
admet-31	199	16	in	in	ADP
admet-31	199	17	the	the	DET
admet-31	199	18	analysis	analysis	NOUN
admet-31	199	19	of	of	ADP
admet-31	199	20	dissolution	dissolution	ADJ
admet-31	199	21	mechanisms	mechanism	NOUN
admet-31	199	22	of	of	ADP
admet-31	199	23	sparingly	sparingly	ADV
admet-31	199	24	soluble	soluble	ADJ
admet-31	199	25	drugs	drug	NOUN
admet-31	199	26	,	,	PUNCT
admet-31	199	27	which	which	PRON
admet-31	199	28	depend	depend	VERB
admet-31	199	29	on	on	ADP
admet-31	199	30	the	the	DET
admet-31	199	31	stoichiometry	stoichiometry	NOUN
admet-31	199	32	and	and	CCONJ
admet-31	199	33	solubility	solubility	NOUN
admet-31	199	34	of	of	ADP
admet-31	199	35	drug	drug	NOUN
admet-31	199	36	species	specie	NOUN
admet-31	199	37	,	,	PUNCT
admet-31	199	38	especially	especially	ADV
admet-31	199	39	of	of	ADP
admet-31	199	40	salts	salt	NOUN
admet-31	199	41	.	.	PUNCT
admet-31	200	1	acknowledgements	acknowledgement	NOUN
admet-31	200	2	helpful	helpful	ADJ
admet-31	200	3	discussions	discussion	NOUN
admet-31	200	4	with	with	ADP
admet-31	200	5	christel	christel	PROPN
admet-31	200	6	bergström	bergström	PROPN
admet-31	200	7	of	of	ADP
admet-31	200	8	uppsala	uppsala	PROPN
admet-31	200	9	university	university	PROPN
admet-31	200	10	,	,	PUNCT
admet-31	200	11	and	and	CCONJ
admet-31	200	12	gergely	gergely	ADV
admet-31	200	13	völgyi	völgyi	NOUN
admet-31	200	14	and	and	CCONJ
admet-31	200	15	krisztina	krisztina	VERB
admet-31	200	16	takács	takács	PROPN
admet-31	200	17	-	-	PUNCT
admet-31	200	18	novák	novák	NOUN
admet-31	200	19	of	of	ADP
admet-31	200	20	semmelweis	semmelweis	PROPN
admet-31	200	21	university	university	PROPN
admet-31	200	22	(	(	PUNCT
admet-31	200	23	budapest	budapest	ADJ
admet-31	200	24	)	)	PUNCT
admet-31	200	25	are	be	AUX
admet-31	200	26	greatly	greatly	ADV
admet-31	200	27	appreciated	appreciate	VERB
admet-31	200	28	.	.	PUNCT
admet-31	201	1	admet	admet	PROPN
admet-31	201	2	&	&	CCONJ
admet-31	201	3	dmpk	dmpk	PROPN
admet-31	201	4	2(1	2(1	NUM
admet-31	201	5	)	)	PUNCT
admet-31	201	6	(	(	PUNCT
admet-31	201	7	2014	2014	NUM
admet-31	201	8	)	)	PUNCT
admet-31	201	9	43	43	NUM
admet-31	201	10	-	-	SYM
admet-31	201	11	55	55	NUM
admet-31	201	12	phosphate	phosphate	NOUN
admet-31	201	13	precipitates	precipitate	NOUN
admet-31	201	14	&	&	CCONJ
admet-31	201	15	aggregates	aggregate	NOUN
admet-31	201	16	of	of	ADP
admet-31	201	17	basic	basic	ADJ
admet-31	201	18	drugs	drug	NOUN
admet-31	201	19	doi	doi	NOUN
admet-31	201	20	:	:	PUNCT
admet-31	201	21	10.5599	10.5599	NUM
admet-31	201	22	/	/	SYM
admet-31	201	23	admet.2.1.31	admet.2.1.31	PROPN
admet-31	201	24	55	55	NUM
admet-31	201	25	references	reference	NOUN
admet-31	201	26	[	[	X
admet-31	201	27	1	1	NUM
admet-31	201	28	]	]	PUNCT
admet-31	201	29	a.	a.	NOUN
admet-31	201	30	avdeef	avdeef	PROPN
admet-31	201	31	.	.	PUNCT
admet-31	202	1	absorption	absorption	NOUN
admet-31	202	2	and	and	CCONJ
admet-31	202	3	drug	drug	NOUN
admet-31	202	4	development	development	PROPN
admet-31	202	5	second	second	PROPN
admet-31	202	6	edition	edition	NOUN
admet-31	202	7	,	,	PUNCT
admet-31	202	8	wiley	wiley	NOUN
admet-31	202	9	-	-	PUNCT
admet-31	202	10	interscience	interscience	PROPN
admet-31	202	11	,	,	PUNCT
admet-31	202	12	hoboken	hoboken	PROPN
admet-31	202	13	,	,	PUNCT
admet-31	202	14	nj	nj	PROPN
admet-31	202	15	,	,	PUNCT
admet-31	202	16	2012	2012	NUM
admet-31	202	17	,	,	PUNCT
admet-31	202	18	pp	pp	ADV
admet-31	202	19	.	.	PUNCT
admet-31	203	1	251	251	NUM
admet-31	203	2	-	-	SYM
admet-31	203	3	318	318	NUM
admet-31	203	4	.	.	PUNCT
admet-31	204	1	[	[	X
admet-31	204	2	2	2	NUM
admet-31	204	3	]	]	PUNCT
admet-31	204	4	a.	a.	NOUN
admet-31	204	5	glomme	glomme	PROPN
admet-31	204	6	,	,	PUNCT
admet-31	204	7	j.	j.	PROPN
admet-31	204	8	märz	märz	PROPN
admet-31	204	9	,	,	PUNCT
admet-31	204	10	j.b	j.b	PROPN
admet-31	204	11	.	.	PROPN
admet-31	204	12	dressman	dressman	PROPN
admet-31	204	13	.	.	PUNCT
admet-31	205	1	in	in	ADP
admet-31	205	2	:	:	PUNCT
admet-31	205	3	b.	b.	PROPN
admet-31	205	4	testa	testa	PROPN
admet-31	205	5	,	,	PUNCT
admet-31	205	6	s.d	s.d	PROPN
admet-31	205	7	.	.	PROPN
admet-31	205	8	krämer	krämer	PROPN
admet-31	205	9	,	,	PUNCT
admet-31	205	10	h.	h.	PROPN
admet-31	205	11	wunderli	wunderli	NOUN
admet-31	205	12	-	-	PUNCT
admet-31	205	13	allenspach	allenspach	NOUN
admet-31	205	14	,	,	PUNCT
admet-31	205	15	g.	g.	PROPN
admet-31	205	16	folkers	folker	NOUN
admet-31	205	17	(	(	PUNCT
admet-31	205	18	eds	ed	NOUN
admet-31	205	19	.	.	PUNCT
admet-31	205	20	)	)	PUNCT
admet-31	205	21	,	,	PUNCT
admet-31	205	22	pharmacokinetic	pharmacokinetic	ADJ
admet-31	205	23	profiling	profiling	NOUN
admet-31	205	24	in	in	ADP
admet-31	205	25	drug	drug	NOUN
admet-31	205	26	research	research	NOUN
admet-31	205	27	:	:	PUNCT
admet-31	205	28	biological	biological	ADJ
admet-31	205	29	,	,	PUNCT
admet-31	205	30	physicochemical	physicochemical	ADJ
admet-31	205	31	,	,	PUNCT
admet-31	205	32	and	and	CCONJ
admet-31	205	33	computational	computational	ADJ
admet-31	205	34	strategies	strategy	NOUN
admet-31	205	35	,	,	PUNCT
admet-31	205	36	wiley	wiley	PROPN
admet-31	205	37	-	-	PUNCT
admet-31	205	38	vch	vch	PROPN
admet-31	205	39	,	,	PUNCT
admet-31	205	40	weinheim	weinheim	PROPN
admet-31	205	41	,	,	PUNCT
admet-31	205	42	2006	2006	NUM
admet-31	205	43	,	,	PUNCT
admet-31	205	44	pp	pp	ADV
admet-31	205	45	.	.	PUNCT
admet-31	206	1	259–280	259–280	NUM
admet-31	206	2	.	.	PUNCT
admet-31	207	1	[	[	X
admet-31	207	2	3	3	X
admet-31	207	3	]	]	X
admet-31	207	4	j.h	j.h	PROPN
admet-31	207	5	.	.	PROPN
admet-31	207	6	fagerberg	fagerberg	PROPN
admet-31	207	7	,	,	PUNCT
admet-31	207	8	o.	o.	PROPN
admet-31	207	9	tsinman	tsinman	PROPN
admet-31	207	10	,	,	PUNCT
admet-31	207	11	k.	k.	PROPN
admet-31	207	12	tsinman	tsinman	PROPN
admet-31	207	13	,	,	PUNCT
admet-31	207	14	n.	n.	PROPN
admet-31	207	15	sun	sun	PROPN
admet-31	207	16	,	,	PUNCT
admet-31	207	17	a.	a.	NOUN
admet-31	207	18	avdeef	avdeef	PROPN
admet-31	207	19	,	,	PUNCT
admet-31	207	20	c.a.s	c.a.	VERB
admet-31	207	21	.	.	PROPN
admet-31	207	22	bergström	bergström	PROPN
admet-31	207	23	.	.	PUNCT
admet-31	208	1	mol	mol	PROPN
admet-31	208	2	.	.	PUNCT
admet-31	209	1	pharmaceutics	pharmaceutic	NOUN
admet-31	209	2	7	7	NUM
admet-31	209	3	,	,	PUNCT
admet-31	209	4	(	(	PUNCT
admet-31	209	5	2010	2010	NUM
admet-31	209	6	)	)	PUNCT
admet-31	209	7	1419	1419	NUM
admet-31	209	8	-	-	SYM
admet-31	209	9	1430	1430	NUM
admet-31	209	10	.	.	PUNCT
admet-31	210	1	[	[	X
admet-31	210	2	4	4	NUM
admet-31	210	3	]	]	PUNCT
admet-31	210	4	a.	a.	NOUN
admet-31	210	5	avdeef	avdeef	PROPN
admet-31	210	6	,	,	PUNCT
admet-31	210	7	o.	o.	PROPN
admet-31	210	8	tsinman	tsinman	NOUN
admet-31	210	9	.	.	PUNCT
admet-31	211	1	pharm	pharm	PROPN
admet-31	211	2	.	.	PUNCT
admet-31	212	1	res	re	NOUN
admet-31	212	2	.	.	PROPN
admet-31	213	1	25	25	NUM
admet-31	213	2	(	(	PUNCT
admet-31	213	3	2008	2008	NUM
admet-31	213	4	)	)	PUNCT
admet-31	213	5	2613	2613	NUM
admet-31	213	6	-	-	SYM
admet-31	213	7	2627	2627	NUM
admet-31	213	8	.	.	PUNCT
admet-31	214	1	[	[	X
admet-31	214	2	5	5	NUM
admet-31	214	3	]	]	PUNCT
admet-31	214	4	a.	a.	NOUN
admet-31	214	5	avdeef	avdeef	PROPN
admet-31	214	6	.	.	PUNCT
admet-31	215	1	adv	adv	PROPN
admet-31	215	2	.	.	PUNCT
admet-31	215	3	drug	drug	PROPN
admet-31	215	4	deliv	deliv	PROPN
admet-31	215	5	.	.	PUNCT
admet-31	216	1	rev	rev	PROPN
admet-31	216	2	.	.	PROPN
admet-31	216	3	59	59	NUM
admet-31	216	4	(	(	PUNCT
admet-31	216	5	2007	2007	NUM
admet-31	216	6	)	)	PUNCT
admet-31	216	7	568	568	NUM
admet-31	216	8	-	-	SYM
admet-31	216	9	590	590	NUM
admet-31	216	10	.	.	PUNCT
admet-31	217	1	[	[	X
admet-31	217	2	6	6	NUM
admet-31	217	3	]	]	PUNCT
admet-31	217	4	a.	a.	NOUN
admet-31	217	5	avdeef	avdeef	PROPN
admet-31	217	6	,	,	PUNCT
admet-31	217	7	k.y	k.y	PROPN
admet-31	217	8	.	.	PROPN
admet-31	217	9	tam	tam	PROPN
admet-31	217	10	.	.	PUNCT
admet-31	217	11	j.	j.	PROPN
admet-31	217	12	med	med	PROPN
admet-31	217	13	.	.	PROPN
admet-31	217	14	chem	chem	PROPN
admet-31	217	15	.	.	PUNCT
admet-31	218	1	53	53	NUM
admet-31	218	2	(	(	PUNCT
admet-31	218	3	2010	2010	NUM
admet-31	218	4	)	)	PUNCT
admet-31	218	5	3566	3566	NUM
admet-31	218	6	-	-	SYM
admet-31	218	7	3584	3584	NUM
admet-31	218	8	.	.	PUNCT
admet-31	219	1	[	[	X
admet-31	219	2	7	7	X
admet-31	219	3	]	]	X
admet-31	219	4	t.	t.	PROPN
admet-31	219	5	higuchi	higuchi	PROPN
admet-31	219	6	,	,	PUNCT
admet-31	219	7	m.	m.	NOUN
admet-31	219	8	gupta	gupta	PROPN
admet-31	219	9	,	,	PUNCT
admet-31	219	10	l.w	l.w	PROPN
admet-31	219	11	.	.	PROPN
admet-31	219	12	busse	busse	PROPN
admet-31	219	13	.	.	PUNCT
admet-31	220	1	j.	j.	PROPN
admet-31	220	2	am	am	PROPN
admet-31	220	3	.	.	PUNCT
admet-31	221	1	pharm	pharm	PROPN
admet-31	221	2	.	.	PUNCT
admet-31	222	1	assoc	assoc	PROPN
admet-31	222	2	.	.	PUNCT
admet-31	223	1	42	42	NUM
admet-31	223	2	(	(	PUNCT
admet-31	223	3	1953	1953	NUM
admet-31	223	4	)	)	PUNCT
admet-31	223	5	157	157	NUM
admet-31	223	6	-	-	SYM
admet-31	223	7	161	161	NUM
admet-31	223	8	.	.	PUNCT
admet-31	224	1	[	[	X
admet-31	224	2	8	8	NUM
admet-31	224	3	]	]	X
admet-31	224	4	j.b	j.b	PROPN
admet-31	224	5	.	.	PROPN
admet-31	224	6	bogardus	bogardus	PROPN
admet-31	224	7	,	,	PUNCT
admet-31	224	8	r.k	r.k	PROPN
admet-31	224	9	.	.	PROPN
admet-31	224	10	blackwood	blackwood	PROPN
admet-31	224	11	,	,	PUNCT
admet-31	224	12	jr	jr	PROPN
admet-31	224	13	.	.	PUNCT
admet-31	224	14	j.	j.	PROPN
admet-31	224	15	pharm	pharm	PROPN
admet-31	224	16	.	.	PUNCT
admet-31	225	1	sci	sci	PROPN
admet-31	225	2	.	.	PROPN
admet-31	226	1	68	68	NUM
admet-31	226	2	(	(	PUNCT
admet-31	226	3	1979	1979	NUM
admet-31	226	4	)	)	PUNCT
admet-31	226	5	188	188	NUM
admet-31	226	6	-	-	SYM
admet-31	226	7	194	194	NUM
admet-31	226	8	.	.	PUNCT
admet-31	227	1	[	[	X
admet-31	227	2	9	9	NUM
admet-31	227	3	]	]	PUNCT
admet-31	227	4	c.	c.	PROPN
admet-31	227	5	zhu	zhu	PROPN
admet-31	227	6	,	,	PUNCT
admet-31	227	7	w.h	w.h	PROPN
admet-31	227	8	.	.	PROPN
admet-31	227	9	streng	streng	PROPN
admet-31	227	10	.	.	PUNCT
admet-31	228	1	int	int	NOUN
admet-31	228	2	.	.	PUNCT
admet-31	229	1	j.	j.	PROPN
admet-31	229	2	pharm	pharm	PROPN
admet-31	229	3	.	.	PUNCT
admet-31	230	1	130	130	NUM
admet-31	230	2	(	(	PUNCT
admet-31	230	3	1996	1996	NUM
admet-31	230	4	)	)	PUNCT
admet-31	230	5	159	159	NUM
admet-31	230	6	-	-	SYM
admet-31	230	7	168	168	NUM
admet-31	230	8	.	.	PUNCT
admet-31	231	1	[	[	X
admet-31	231	2	10	10	NUM
admet-31	231	3	]	]	PUNCT
admet-31	231	4	a.	a.	NOUN
admet-31	231	5	fini	fini	PROPN
admet-31	231	6	,	,	PUNCT
admet-31	231	7	g.	g.	PROPN
admet-31	231	8	fazio	fazio	PROPN
admet-31	231	9	,	,	PUNCT
admet-31	231	10	g.	g.	PROPN
admet-31	231	11	feroci	feroci	PROPN
admet-31	231	12	.	.	PUNCT
admet-31	232	1	int	int	NOUN
admet-31	232	2	.	.	PUNCT
admet-31	233	1	j.	j.	PROPN
admet-31	233	2	pharm	pharm	PROPN
admet-31	233	3	.	.	PUNCT
admet-31	234	1	126	126	NUM
admet-31	234	2	(	(	PUNCT
admet-31	234	3	1995	1995	NUM
admet-31	234	4	)	)	PUNCT
admet-31	234	5	95	95	NUM
admet-31	234	6	-	-	SYM
admet-31	234	7	102	102	NUM
admet-31	234	8	.	.	PUNCT
admet-31	235	1	[	[	X
admet-31	235	2	11	11	NUM
admet-31	235	3	]	]	X
admet-31	235	4	g.	g.	PROPN
admet-31	235	5	völgyi	völgyi	PROPN
admet-31	235	6	,	,	PUNCT
admet-31	235	7	a.	a.	NOUN
admet-31	235	8	marosi	marosi	PROPN
admet-31	235	9	,	,	PUNCT
admet-31	235	10	k.	k.	PROPN
admet-31	235	11	takács	takács	PROPN
admet-31	235	12	-	-	PUNCT
admet-31	235	13	novák	novák	PROPN
admet-31	235	14	,	,	PUNCT
admet-31	235	15	a.	a.	PROPN
admet-31	235	16	avdeef	avdeef	PROPN
admet-31	235	17	.	.	PUNCT
admet-31	236	1	admet	admet	PROPN
admet-31	236	2	&	&	CCONJ
admet-31	236	3	dmpk	dmpk	PROPN
admet-31	236	4	1(4	1(4	NUM
admet-31	236	5	)	)	PUNCT
admet-31	236	6	(	(	PUNCT
admet-31	236	7	2013	2013	NUM
admet-31	236	8	)	)	PUNCT
admet-31	236	9	48	48	NUM
admet-31	236	10	-	-	SYM
admet-31	236	11	62	62	NUM
admet-31	236	12	.	.	PUNCT
admet-31	237	1	[	[	X
admet-31	237	2	12	12	NUM
admet-31	237	3	]	]	PUNCT
admet-31	237	4	a.	a.	NOUN
admet-31	237	5	avdeef	avdeef	PROPN
admet-31	237	6	.	.	PUNCT
admet-31	238	1	admet	admet	PROPN
admet-31	238	2	&	&	CCONJ
admet-31	238	3	dmpk	dmpk	PROPN
admet-31	238	4	2	2	NUM
admet-31	238	5	(	(	PUNCT
admet-31	238	6	2014	2014	NUM
admet-31	238	7	)	)	PUNCT
admet-31	238	8	33	33	NUM
admet-31	238	9	-	-	SYM
admet-31	238	10	42	42	NUM
admet-31	239	1	[	[	X
admet-31	239	2	13	13	NUM
admet-31	239	3	]	]	PUNCT
admet-31	239	4	bergström	bergström	NOUN
admet-31	239	5	cas	cas	PROPN
admet-31	239	6	,	,	PUNCT
admet-31	239	7	luthman	luthman	PROPN
admet-31	239	8	k	k	PROPN
admet-31	239	9	,	,	PUNCT
admet-31	239	10	artursson	artursson	PROPN
admet-31	239	11	p.	p.	PROPN
admet-31	239	12	eur	eur	PROPN
admet-31	239	13	.	.	PUNCT
admet-31	240	1	j.	j.	PROPN
admet-31	240	2	pharm	pharm	PROPN
admet-31	240	3	.	.	PUNCT
admet-31	241	1	sci	sci	PROPN
admet-31	241	2	.	.	PROPN
admet-31	242	1	24	24	NUM
admet-31	242	2	(	(	PUNCT
admet-31	242	3	2004	2004	NUM
admet-31	242	4	)	)	PUNCT
admet-31	242	5	387	387	NUM
admet-31	242	6	-	-	SYM
admet-31	242	7	398	398	NUM
admet-31	242	8	.	.	PUNCT
admet-31	243	1	[	[	X
admet-31	243	2	14	14	NUM
admet-31	243	3	]	]	X
admet-31	243	4	w.h	w.h	PROPN
admet-31	243	5	.	.	PROPN
admet-31	243	6	streng	streng	PROPN
admet-31	243	7	.	.	PUNCT
admet-31	244	1	int	int	NOUN
admet-31	244	2	.	.	PUNCT
admet-31	245	1	j.	j.	PROPN
admet-31	245	2	pharm	pharm	PROPN
admet-31	245	3	.	.	PUNCT
admet-31	246	1	186	186	NUM
admet-31	246	2	(	(	PUNCT
admet-31	246	3	1999	1999	NUM
admet-31	246	4	)	)	PUNCT
admet-31	246	5	137–140	137–140	NUM
admet-31	246	6	.	.	PUNCT
admet-31	247	1	[	[	X
admet-31	247	2	15	15	NUM
admet-31	247	3	]	]	X
admet-31	247	4	a.	a.	NOUN
admet-31	247	5	avdeef	avdeef	PROPN
admet-31	247	6	.	.	PUNCT
admet-31	248	1	pharm	pharm	PROPN
admet-31	248	2	.	.	PUNCT
admet-31	249	1	pharmacol	pharmacol	PROPN
admet-31	249	2	.	.	PUNCT
admet-31	250	1	commun	commun	PROPN
admet-31	250	2	.	.	PUNCT
admet-31	251	1	4	4	NUM
admet-31	251	2	(	(	PUNCT
admet-31	251	3	1998	1998	NUM
admet-31	251	4	)	)	PUNCT
admet-31	251	5	165	165	NUM
admet-31	251	6	-	-	SYM
admet-31	251	7	178	178	NUM
admet-31	251	8	.	.	PUNCT
admet-31	252	1	[	[	X
admet-31	252	2	16	16	NUM
admet-31	252	3	]	]	X
admet-31	252	4	amiodarone	amiodarone	NOUN
admet-31	252	5	-	-	PUNCT
admet-31	252	6	containing	contain	VERB
admet-31	252	7	parenteral	parenteral	ADJ
admet-31	252	8	solution	solution	NOUN
admet-31	252	9	patent	patent	NOUN
admet-31	252	10	:	:	PUNCT
admet-31	252	11	ep	ep	PROPN
admet-31	252	12	1	1	NUM
admet-31	252	13	267	267	NUM
admet-31	252	14	865	865	NUM
admet-31	252	15	b1	b1	NOUN
admet-31	252	16	(	(	PUNCT
admet-31	252	17	15	15	NUM
admet-31	252	18	feb	feb	NOUN
admet-31	252	19	2006	2006	NUM
admet-31	252	20	)	)	PUNCT
admet-31	252	21	.	.	PUNCT
admet-31	253	1	©	©	PROPN
admet-31	253	2	2014	2014	NUM
admet-31	253	3	by	by	ADP
admet-31	253	4	the	the	DET
admet-31	253	5	authors	author	NOUN
admet-31	253	6	;	;	PUNCT
admet-31	253	7	licensee	licensee	PROPN
admet-31	253	8	iapc	iapc	PROPN
admet-31	253	9	,	,	PUNCT
admet-31	253	10	zagreb	zagreb	PROPN
admet-31	253	11	,	,	PUNCT
admet-31	253	12	croatia	croatia	PROPN
admet-31	253	13	.	.	PUNCT
admet-31	254	1	this	this	DET
admet-31	254	2	article	article	NOUN
admet-31	254	3	is	be	AUX
admet-31	254	4	an	an	DET
admet-31	254	5	open	open	ADJ
admet-31	254	6	-	-	PUNCT
admet-31	254	7	access	access	NOUN
admet-31	254	8	article	article	NOUN
admet-31	254	9	distributed	distribute	VERB
admet-31	254	10	under	under	ADP
admet-31	254	11	the	the	DET
admet-31	254	12	terms	term	NOUN
admet-31	254	13	and	and	CCONJ
admet-31	254	14	conditions	condition	NOUN
admet-31	254	15	of	of	ADP
admet-31	254	16	the	the	DET
admet-31	254	17	creative	creative	ADJ
admet-31	254	18	commons	common	NOUN
admet-31	254	19	attribution	attribution	NOUN
admet-31	254	20	license	license	NOUN
admet-31	254	21	(	(	PUNCT
admet-31	254	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-31	254	23	)	)	PUNCT
admet-31	254	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN