id	sid	tid	token	lemma	pos
admet-317	1	1	manuscript	manuscript	PROPN
admet-317	1	2	doi	doi	PROPN
admet-317	1	3	:	:	PUNCT
admet-317	1	4	10.5599	10.5599	NUM
admet-317	1	5	/	/	SYM
admet-317	1	6	admet.4.2.317	admet.4.2.317	PROPN
admet-317	1	7	114	114	NUM
admet-317	1	8	admet	admet	NOUN
admet-317	1	9	&	&	CCONJ
admet-317	1	10	dmpk	dmpk	PROPN
admet-317	1	11	4(2	4(2	NUM
admet-317	1	12	)	)	PUNCT
admet-317	1	13	(	(	PUNCT
admet-317	1	14	2016	2016	NUM
admet-317	1	15	)	)	PUNCT
admet-317	1	16	114	114	NUM
admet-317	1	17	-	-	SYM
admet-317	1	18	116	116	NUM
admet-317	1	19	;	;	PUNCT
admet-317	1	20	doi	doi	NOUN
admet-317	1	21	:	:	PUNCT
admet-317	1	22	10.5599	10.5599	NUM
admet-317	1	23	/	/	SYM
admet-317	1	24	admet.4.2.317	admet.4.2.317	PRON
admet-317	1	25	open	open	ADJ
admet-317	1	26	access	access	NOUN
admet-317	1	27	:	:	PUNCT
admet-317	1	28	issn	issn	PROPN
admet-317	1	29	:	:	PUNCT
admet-317	1	30	1848	1848	NUM
admet-317	1	31	-	-	SYM
admet-317	1	32	7718	7718	NUM
admet-317	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-317	1	34	opinion	opinion	NOUN
admet-317	1	35	is	be	AUX
admet-317	1	36	there	there	PRON
admet-317	1	37	a	a	DET
admet-317	1	38	paradigm	paradigm	NOUN
admet-317	1	39	shift	shift	NOUN
admet-317	1	40	in	in	ADP
admet-317	1	41	use	use	NOUN
admet-317	1	42	of	of	ADP
admet-317	1	43	microsomes	microsome	NOUN
admet-317	1	44	and	and	CCONJ
admet-317	1	45	hepatocytes	hepatocyte	NOUN
admet-317	1	46	in	in	ADP
admet-317	1	47	drug	drug	NOUN
admet-317	1	48	discovery	discovery	NOUN
admet-317	1	49	and	and	CCONJ
admet-317	1	50	development	development	NOUN
admet-317	1	51	?	?	PUNCT
admet-317	2	1	sumit	sumit	PROPN
admet-317	2	2	basu	basu	PROPN
admet-317	2	3	,	,	PUNCT
admet-317	2	4	abdul	abdul	PROPN
admet-317	2	5	naveed	naveed	PROPN
admet-317	2	6	shaik	shaik	PROPN
admet-317	2	7	*	*	PROPN
admet-317	2	8	center	center	PROPN
admet-317	2	9	for	for	ADP
admet-317	2	10	pharmacometrics	pharmacometric	NOUN
admet-317	2	11	and	and	CCONJ
admet-317	2	12	systems	system	NOUN
admet-317	2	13	pharmacology	pharmacology	NOUN
admet-317	2	14	,	,	PUNCT
admet-317	2	15	department	department	NOUN
admet-317	2	16	of	of	ADP
admet-317	2	17	pharmaceutics	pharmaceutic	NOUN
admet-317	2	18	,	,	PUNCT
admet-317	2	19	university	university	PROPN
admet-317	2	20	of	of	ADP
admet-317	2	21	florida	florida	PROPN
admet-317	2	22	.	.	PUNCT
admet-317	3	1	orlando	orlando	PROPN
admet-317	3	2	fl	fl	PROPN
admet-317	3	3	.	.	PUNCT
admet-317	4	1	*	*	PUNCT
admet-317	4	2	corresponding	correspond	VERB
admet-317	4	3	author	author	NOUN
admet-317	4	4	:	:	PUNCT
admet-317	4	5	e	e	NOUN
admet-317	4	6	-	-	NOUN
admet-317	4	7	mail	mail	NOUN
admet-317	4	8	:	:	PUNCT
admet-317	4	9	naveedshaik@gmail.com	naveedshaik@gmail.com	NUM
admet-317	4	10	;	;	PUNCT
admet-317	4	11	tel	tel	PROPN
admet-317	4	12	.	.	PUNCT
admet-317	4	13	:	:	PUNCT
admet-317	5	1	+1	+1	ADJ
admet-317	5	2	-	-	PUNCT
admet-317	5	3	407	407	NUM
admet-317	5	4	-	-	PUNCT
admet-317	5	5	313	313	NUM
admet-317	5	6	-	-	SYM
admet-317	5	7	7009	7009	NUM
admet-317	5	8	.	.	PUNCT
admet-317	6	1	received	receive	VERB
admet-317	6	2	:	:	PUNCT
admet-317	6	3	june	june	PROPN
admet-317	6	4	13	13	NUM
admet-317	6	5	,	,	PUNCT
admet-317	6	6	2016	2016	NUM
admet-317	6	7	;	;	PUNCT
admet-317	6	8	revised	revise	VERB
admet-317	6	9	:	:	PUNCT
admet-317	6	10	june	june	PROPN
admet-317	6	11	20	20	NUM
admet-317	6	12	,	,	PUNCT
admet-317	6	13	2016	2016	NUM
admet-317	6	14	;	;	PUNCT
admet-317	6	15	published	publish	VERB
admet-317	6	16	:	:	PUNCT
admet-317	6	17	june	june	PROPN
admet-317	6	18	29	29	NUM
admet-317	6	19	,	,	PUNCT
admet-317	6	20	2016	2016	NUM
admet-317	6	21	in	in	ADP
admet-317	6	22	last	last	ADJ
admet-317	6	23	two	two	NUM
admet-317	6	24	decades	decade	NOUN
admet-317	6	25	,	,	PUNCT
admet-317	6	26	the	the	DET
admet-317	6	27	field	field	NOUN
admet-317	6	28	of	of	ADP
admet-317	6	29	drug	drug	NOUN
admet-317	6	30	metabolism	metabolism	NOUN
admet-317	6	31	and	and	CCONJ
admet-317	6	32	pharmacokinetics	pharmacokinetic	NOUN
admet-317	6	33	(	(	PUNCT
admet-317	6	34	dmpk	dmpk	NOUN
admet-317	6	35	)	)	PUNCT
admet-317	6	36	has	have	AUX
admet-317	6	37	been	be	AUX
admet-317	6	38	considerably	considerably	ADV
admet-317	6	39	improved	improve	VERB
admet-317	6	40	due	due	ADJ
admet-317	6	41	to	to	ADP
admet-317	6	42	various	various	ADJ
admet-317	6	43	reasons	reason	NOUN
admet-317	6	44	,	,	PUNCT
admet-317	6	45	i.e.	i.e.	X
admet-317	6	46	,	,	PUNCT
admet-317	6	47	routine	routine	ADJ
admet-317	6	48	incorporation	incorporation	NOUN
admet-317	6	49	of	of	ADP
admet-317	6	50	dmpk	dmpk	NOUN
admet-317	6	51	into	into	ADP
admet-317	6	52	early	early	ADJ
admet-317	6	53	drug	drug	NOUN
admet-317	6	54	discovery	discovery	NOUN
admet-317	6	55	,	,	PUNCT
admet-317	6	56	better	well	ADJ
admet-317	6	57	understanding	understanding	NOUN
admet-317	6	58	of	of	ADP
admet-317	6	59	drug	drug	NOUN
admet-317	6	60	dispositional	dispositional	ADJ
admet-317	6	61	elements	element	NOUN
admet-317	6	62	(	(	PUNCT
admet-317	6	63	drug	drug	NOUN
admet-317	6	64	metabolizing	metabolize	VERB
admet-317	6	65	enzymes	enzyme	NOUN
admet-317	6	66	and	and	CCONJ
admet-317	6	67	uptake	uptake	ADJ
admet-317	6	68	/	/	SYM
admet-317	6	69	efflux	efflux	NOUN
admet-317	6	70	transporters	transporter	NOUN
admet-317	6	71	)	)	PUNCT
admet-317	6	72	and	and	CCONJ
admet-317	6	73	implementation	implementation	NOUN
admet-317	6	74	of	of	ADP
admet-317	6	75	optimized	optimize	VERB
admet-317	6	76	dmpk	dmpk	NOUN
admet-317	6	77	properties	property	NOUN
admet-317	6	78	in	in	ADP
admet-317	6	79	preclinical	preclinical	ADJ
admet-317	6	80	drug	drug	NOUN
admet-317	6	81	discovery	discovery	NOUN
admet-317	6	82	and	and	CCONJ
admet-317	6	83	development	development	NOUN
admet-317	6	84	.	.	PUNCT
admet-317	7	1	in	in	ADP
admet-317	7	2	this	this	DET
admet-317	7	3	regard	regard	NOUN
admet-317	7	4	,	,	PUNCT
admet-317	7	5	both	both	PRON
admet-317	7	6	in	in	ADP
admet-317	7	7	vitro	vitro	X
admet-317	7	8	and	and	CCONJ
admet-317	7	9	in	in	ADP
admet-317	7	10	vivo	vivo	ADJ
admet-317	7	11	experimental	experimental	ADJ
admet-317	7	12	tools	tool	NOUN
admet-317	7	13	play	play	VERB
admet-317	7	14	significant	significant	ADJ
admet-317	7	15	role	role	NOUN
admet-317	7	16	to	to	PART
admet-317	7	17	understand	understand	VERB
admet-317	7	18	different	different	ADJ
admet-317	7	19	critical	critical	ADJ
admet-317	7	20	absorption	absorption	NOUN
admet-317	7	21	,	,	PUNCT
admet-317	7	22	distribution	distribution	NOUN
admet-317	7	23	,	,	PUNCT
admet-317	7	24	metabolism	metabolism	NOUN
admet-317	7	25	and	and	CCONJ
admet-317	7	26	elimination	elimination	NOUN
admet-317	7	27	(	(	PUNCT
admet-317	7	28	adme	adme	NOUN
admet-317	7	29	)	)	PUNCT
admet-317	7	30	parameters	parameter	NOUN
admet-317	7	31	which	which	PRON
admet-317	7	32	accelerated	accelerate	VERB
admet-317	7	33	tremendously	tremendously	ADV
admet-317	7	34	the	the	DET
admet-317	7	35	lead	lead	ADJ
admet-317	7	36	selection	selection	NOUN
admet-317	7	37	,	,	PUNCT
admet-317	7	38	lead	lead	VERB
admet-317	7	39	optimization	optimization	NOUN
admet-317	7	40	and	and	CCONJ
admet-317	7	41	the	the	DET
admet-317	7	42	preclinical	preclinical	ADJ
admet-317	7	43	development	development	NOUN
admet-317	7	44	of	of	ADP
admet-317	7	45	the	the	DET
admet-317	7	46	drug	drug	NOUN
admet-317	7	47	candidate	candidate	NOUN
admet-317	7	48	prior	prior	ADV
admet-317	7	49	to	to	ADP
admet-317	7	50	the	the	DET
admet-317	7	51	clinical	clinical	ADJ
admet-317	7	52	trials	trial	NOUN
admet-317	7	53	.	.	PUNCT
admet-317	8	1	among	among	ADP
admet-317	8	2	these	these	DET
admet-317	8	3	experimental	experimental	ADJ
admet-317	8	4	tools	tool	NOUN
admet-317	8	5	,	,	PUNCT
admet-317	8	6	in	in	ADP
admet-317	8	7	vitro	vitro	X
admet-317	8	8	assays	assay	NOUN
admet-317	8	9	are	be	AUX
admet-317	8	10	quite	quite	ADV
admet-317	8	11	advantageous	advantageous	ADJ
admet-317	8	12	in	in	ADP
admet-317	8	13	comparison	comparison	NOUN
admet-317	8	14	to	to	ADP
admet-317	8	15	the	the	DET
admet-317	8	16	in	in	ADP
admet-317	8	17	vivo	vivo	NOUN
admet-317	8	18	models	model	NOUN
admet-317	8	19	because	because	SCONJ
admet-317	8	20	of	of	ADP
admet-317	8	21	its	its	PRON
admet-317	8	22	convenient	convenient	ADJ
admet-317	8	23	and	and	CCONJ
admet-317	8	24	economical	economical	ADJ
admet-317	8	25	way	way	NOUN
admet-317	8	26	to	to	PART
admet-317	8	27	address	address	VERB
admet-317	8	28	the	the	DET
admet-317	8	29	specific	specific	ADJ
admet-317	8	30	questions	question	NOUN
admet-317	8	31	in	in	ADP
admet-317	8	32	short	short	ADJ
admet-317	8	33	time	time	NOUN
admet-317	8	34	period	period	NOUN
admet-317	8	35	.	.	PUNCT
admet-317	9	1	these	these	DET
admet-317	9	2	in	in	ADP
admet-317	9	3	vitro	vitro	X
admet-317	9	4	experimental	experimental	ADJ
admet-317	9	5	models	model	NOUN
admet-317	9	6	are	be	AUX
admet-317	9	7	often	often	ADV
admet-317	9	8	employed	employ	VERB
admet-317	9	9	to	to	PART
admet-317	9	10	determine	determine	VERB
admet-317	9	11	the	the	DET
admet-317	9	12	nature	nature	NOUN
admet-317	9	13	of	of	ADP
admet-317	9	14	enzyme	enzyme	NOUN
admet-317	9	15	induction	induction	NOUN
admet-317	9	16	/	/	SYM
admet-317	9	17	inhibition	inhibition	NOUN
admet-317	9	18	(	(	PUNCT
admet-317	9	19	mainly	mainly	ADV
admet-317	9	20	cyps	cyps	PROPN
admet-317	9	21	)	)	PUNCT
admet-317	9	22	in	in	ADP
admet-317	9	23	drug	drug	NOUN
admet-317	9	24	-	-	PUNCT
admet-317	9	25	drug	drug	NOUN
admet-317	9	26	interaction	interaction	NOUN
admet-317	9	27	(	(	PUNCT
admet-317	9	28	ddi	ddi	PROPN
admet-317	9	29	)	)	PUNCT
admet-317	9	30	studies	study	NOUN
admet-317	9	31	,	,	PUNCT
admet-317	9	32	metabolite	metabolite	NOUN
admet-317	9	33	identification	identification	NOUN
admet-317	9	34	,	,	PUNCT
admet-317	9	35	reaction	reaction	NOUN
admet-317	9	36	phenotyping	phenotyping	NOUN
admet-317	9	37	and	and	CCONJ
admet-317	9	38	elucidation	elucidation	NOUN
admet-317	9	39	of	of	ADP
admet-317	9	40	the	the	DET
admet-317	9	41	biotransformation	biotransformation	NOUN
admet-317	9	42	/	/	SYM
admet-317	9	43	metabolic	metabolic	NOUN
admet-317	9	44	pathway	pathway	NOUN
admet-317	9	45	of	of	ADP
admet-317	9	46	new	new	ADJ
admet-317	9	47	chemical	chemical	NOUN
admet-317	9	48	entities	entity	NOUN
admet-317	9	49	(	(	PUNCT
admet-317	9	50	nces	nce	NOUN
admet-317	9	51	)	)	PUNCT
admet-317	10	1	[	[	X
admet-317	10	2	1	1	NUM
admet-317	10	3	,	,	PUNCT
admet-317	10	4	2	2	NUM
admet-317	10	5	]	]	PUNCT
admet-317	10	6	.	.	PUNCT
admet-317	11	1	although	although	SCONJ
admet-317	11	2	it	it	PRON
admet-317	11	3	has	have	AUX
admet-317	11	4	been	be	AUX
admet-317	11	5	shown	show	VERB
admet-317	11	6	that	that	SCONJ
admet-317	11	7	due	due	ADP
admet-317	11	8	to	to	ADP
admet-317	11	9	species	specie	NOUN
admet-317	11	10	related	relate	VERB
admet-317	11	11	differences	difference	NOUN
admet-317	11	12	,	,	PUNCT
admet-317	11	13	preclinical	preclinical	ADJ
admet-317	11	14	species	specie	NOUN
admet-317	11	15	can	can	AUX
admet-317	11	16	not	not	PART
admet-317	11	17	always	always	ADV
admet-317	11	18	predict	predict	VERB
admet-317	11	19	human	human	ADJ
admet-317	11	20	cyp	cyp	ADJ
admet-317	11	21	induction	induction	NOUN
admet-317	11	22	/	/	SYM
admet-317	11	23	inhibition	inhibition	NOUN
admet-317	11	24	;	;	PUNCT
admet-317	11	25	nonetheless	nonetheless	ADV
admet-317	11	26	a	a	DET
admet-317	11	27	good	good	NOUN
admet-317	11	28	in	in	ADP
admet-317	11	29	vitro	vitro	NOUN
admet-317	11	30	-	-	PUNCT
admet-317	11	31	in	in	ADP
admet-317	11	32	vivo	vivo	NOUN
admet-317	11	33	correlation	correlation	NOUN
admet-317	11	34	has	have	AUX
admet-317	11	35	always	always	ADV
admet-317	11	36	been	be	AUX
admet-317	11	37	observed	observe	VERB
admet-317	11	38	when	when	SCONJ
admet-317	11	39	human	human	ADJ
admet-317	11	40	based	base	VERB
admet-317	11	41	in	in	ADP
admet-317	11	42	-	-	PUNCT
admet-317	11	43	vitro	vitro	X
admet-317	11	44	assays	assay	NOUN
admet-317	11	45	have	have	AUX
admet-317	11	46	been	be	AUX
admet-317	11	47	employed	employ	VERB
admet-317	11	48	[	[	X
admet-317	11	49	3	3	NUM
admet-317	11	50	]	]	PUNCT
admet-317	11	51	.	.	PUNCT
admet-317	12	1	in	in	ADP
admet-317	12	2	case	case	NOUN
admet-317	12	3	of	of	ADP
admet-317	12	4	metabolite	metabolite	NOUN
admet-317	12	5	identification	identification	NOUN
admet-317	12	6	and	and	CCONJ
admet-317	12	7	enzyme	enzyme	NOUN
admet-317	12	8	kinetic	kinetic	ADJ
admet-317	12	9	studies	study	NOUN
admet-317	12	10	,	,	PUNCT
admet-317	12	11	the	the	DET
admet-317	12	12	best	good	ADJ
admet-317	12	13	way	way	NOUN
admet-317	12	14	to	to	PART
admet-317	12	15	investigate	investigate	VERB
admet-317	12	16	the	the	DET
admet-317	12	17	metabolic	metabolic	NOUN
admet-317	12	18	profile	profile	NOUN
admet-317	12	19	of	of	ADP
admet-317	12	20	the	the	DET
admet-317	12	21	drug	drug	NOUN
admet-317	12	22	in	in	ADP
admet-317	12	23	a	a	DET
admet-317	12	24	certain	certain	ADJ
admet-317	12	25	tissue	tissue	NOUN
admet-317	12	26	is	be	AUX
admet-317	12	27	to	to	PART
admet-317	12	28	procure	procure	VERB
admet-317	12	29	the	the	DET
admet-317	12	30	tissue	tissue	NOUN
admet-317	12	31	specimen	speciman	NOUN
admet-317	12	32	and	and	CCONJ
admet-317	12	33	evaluate	evaluate	VERB
admet-317	12	34	the	the	DET
admet-317	12	35	activity	activity	NOUN
admet-317	12	36	.	.	PUNCT
admet-317	13	1	in	in	ADP
admet-317	13	2	case	case	NOUN
admet-317	13	3	of	of	ADP
admet-317	13	4	liver	liver	NOUN
admet-317	13	5	,	,	PUNCT
admet-317	13	6	this	this	DET
admet-317	13	7	particular	particular	ADJ
admet-317	13	8	method	method	NOUN
admet-317	13	9	has	have	AUX
admet-317	13	10	been	be	AUX
admet-317	13	11	applied	apply	VERB
admet-317	13	12	successfully	successfully	ADV
admet-317	13	13	and	and	CCONJ
admet-317	13	14	undoubtedly	undoubtedly	ADV
admet-317	13	15	this	this	PRON
admet-317	13	16	is	be	AUX
admet-317	13	17	the	the	DET
admet-317	13	18	method	method	NOUN
admet-317	13	19	of	of	ADP
admet-317	13	20	choice	choice	NOUN
admet-317	13	21	to	to	PART
admet-317	13	22	gain	gain	VERB
admet-317	13	23	information	information	NOUN
admet-317	13	24	on	on	ADP
admet-317	13	25	hepatic	hepatic	ADJ
admet-317	13	26	drug	drug	NOUN
admet-317	13	27	metabolism	metabolism	NOUN
admet-317	13	28	.	.	PUNCT
admet-317	14	1	however	however	ADV
admet-317	14	2	,	,	PUNCT
admet-317	14	3	in	in	ADP
admet-317	14	4	order	order	NOUN
admet-317	14	5	to	to	PART
admet-317	14	6	extrapolate	extrapolate	VERB
admet-317	14	7	the	the	DET
admet-317	14	8	research	research	NOUN
admet-317	14	9	findings	finding	NOUN
admet-317	14	10	in	in	ADP
admet-317	14	11	human	human	NOUN
admet-317	14	12	,	,	PUNCT
admet-317	14	13	we	we	PRON
admet-317	14	14	need	need	VERB
admet-317	14	15	to	to	PART
admet-317	14	16	consider	consider	VERB
admet-317	14	17	additional	additional	ADJ
admet-317	14	18	factors	factor	NOUN
admet-317	14	19	such	such	ADJ
admet-317	14	20	as	as	ADP
admet-317	14	21	ethics	ethic	NOUN
admet-317	14	22	,	,	PUNCT
admet-317	14	23	sampling	sample	VERB
admet-317	14	24	procedure	procedure	NOUN
admet-317	14	25	and	and	CCONJ
admet-317	14	26	bioanalysis	bioanalysis	NOUN
admet-317	14	27	etc	etc	X
admet-317	14	28	.	.	X
admet-317	15	1	in	in	ADP
admet-317	15	2	addition	addition	NOUN
admet-317	15	3	,	,	PUNCT
admet-317	15	4	although	although	SCONJ
admet-317	15	5	a	a	DET
admet-317	15	6	normal	normal	ADJ
admet-317	15	7	liver	liver	NOUN
admet-317	15	8	is	be	AUX
admet-317	15	9	imperative	imperative	ADJ
admet-317	15	10	for	for	ADP
admet-317	15	11	the	the	DET
admet-317	15	12	research	research	NOUN
admet-317	15	13	purpose	purpose	NOUN
admet-317	15	14	,	,	PUNCT
admet-317	15	15	in	in	ADP
admet-317	15	16	reality	reality	NOUN
admet-317	15	17	most	most	ADJ
admet-317	15	18	of	of	ADP
admet-317	15	19	the	the	DET
admet-317	15	20	human	human	ADJ
admet-317	15	21	liver	liver	NOUN
admet-317	15	22	material	material	NOUN
admet-317	15	23	is	be	AUX
admet-317	15	24	pathological	pathological	ADJ
admet-317	15	25	to	to	ADP
admet-317	15	26	some	some	DET
admet-317	15	27	extent	extent	NOUN
admet-317	15	28	.	.	PUNCT
admet-317	16	1	depending	depend	VERB
admet-317	16	2	on	on	ADP
admet-317	16	3	what	what	PRON
admet-317	16	4	kind	kind	NOUN
admet-317	16	5	of	of	ADP
admet-317	16	6	questions	question	NOUN
admet-317	16	7	we	we	PRON
admet-317	16	8	want	want	VERB
admet-317	16	9	to	to	PART
admet-317	16	10	address	address	VERB
admet-317	16	11	,	,	PUNCT
admet-317	16	12	a	a	DET
admet-317	16	13	variety	variety	NOUN
admet-317	16	14	of	of	ADP
admet-317	16	15	different	different	ADJ
admet-317	16	16	preparations	preparation	NOUN
admet-317	16	17	can	can	AUX
admet-317	16	18	be	be	AUX
admet-317	16	19	used	use	VERB
admet-317	16	20	,	,	PUNCT
admet-317	16	21	such	such	ADJ
admet-317	16	22	as	as	ADP
admet-317	16	23	a	a	DET
admet-317	16	24	fully	fully	ADV
admet-317	16	25	physiological	physiological	ADJ
admet-317	16	26	preparation	preparation	NOUN
admet-317	16	27	(	(	PUNCT
admet-317	16	28	e.g.	e.g.	ADV
admet-317	16	29	a	a	DET
admet-317	16	30	whole	whole	ADJ
admet-317	16	31	perfused	perfuse	VERB
admet-317	16	32	liver	liver	NOUN
admet-317	16	33	)	)	PUNCT
admet-317	16	34	or	or	CCONJ
admet-317	16	35	a	a	DET
admet-317	16	36	strictly	strictly	ADV
admet-317	16	37	biochemical	biochemical	ADJ
admet-317	16	38	preparation	preparation	NOUN
admet-317	16	39	(	(	PUNCT
admet-317	16	40	e.g.	e.g.	ADV
admet-317	16	41	cellular	cellular	ADJ
admet-317	16	42	sub	sub	NOUN
admet-317	16	43	-	-	NOUN
admet-317	16	44	fractions	fraction	NOUN
admet-317	16	45	such	such	ADJ
admet-317	16	46	as	as	ADP
admet-317	16	47	microsomes	microsome	NOUN
admet-317	16	48	)	)	PUNCT
admet-317	16	49	or	or	CCONJ
admet-317	16	50	a	a	DET
admet-317	16	51	compromise	compromise	NOUN
admet-317	16	52	situation	situation	NOUN
admet-317	16	53	(	(	PUNCT
admet-317	16	54	e.g.	e.g.	ADV
admet-317	16	55	liver	liver	NOUN
admet-317	16	56	slices	slice	NOUN
admet-317	16	57	,	,	PUNCT
admet-317	16	58	cubes	cube	NOUN
admet-317	16	59	and	and	CCONJ
admet-317	16	60	hepatocytes	hepatocyte	NOUN
admet-317	16	61	etc	etc	X
admet-317	16	62	.	.	PUNCT
admet-317	16	63	)	)	PUNCT
admet-317	16	64	.	.	PUNCT
admet-317	17	1	among	among	ADP
admet-317	17	2	all	all	DET
admet-317	17	3	the	the	DET
admet-317	17	4	established	establish	VERB
admet-317	17	5	in	in	ADP
admet-317	17	6	vitro	vitro	X
admet-317	17	7	experimental	experimental	ADJ
admet-317	17	8	tools	tool	NOUN
admet-317	17	9	,	,	PUNCT
admet-317	17	10	microsomes	microsome	NOUN
admet-317	17	11	are	be	AUX
admet-317	17	12	the	the	DET
admet-317	17	13	mostly	mostly	ADV
admet-317	17	14	widely	widely	ADV
admet-317	17	15	used	use	VERB
admet-317	17	16	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-317	17	17	admet	admet	PROPN
admet-317	17	18	&	&	CCONJ
admet-317	17	19	dmpk	dmpk	PROPN
admet-317	17	20	4(2	4(2	NUM
admet-317	17	21	)	)	PUNCT
admet-317	17	22	(	(	PUNCT
admet-317	17	23	2016	2016	NUM
admet-317	17	24	)	)	PUNCT
admet-317	17	25	114	114	NUM
admet-317	17	26	-	-	SYM
admet-317	17	27	116	116	NUM
admet-317	17	28	use	use	NOUN
admet-317	17	29	of	of	ADP
admet-317	17	30	microsomes	microsome	NOUN
admet-317	17	31	and	and	CCONJ
admet-317	17	32	hepatocytes	hepatocyte	NOUN
admet-317	17	33	in	in	ADP
admet-317	17	34	drug	drug	NOUN
admet-317	17	35	discovery	discovery	NOUN
admet-317	17	36	and	and	CCONJ
admet-317	17	37	development	development	NOUN
admet-317	17	38	doi	doi	PROPN
admet-317	17	39	:	:	PUNCT
admet-317	17	40	10.5599	10.5599	NUM
admet-317	17	41	/	/	SYM
admet-317	17	42	admet.4.2.317	admet.4.2.317	NUM
admet-317	17	43	115	115	NUM
admet-317	17	44	subcellular	subcellular	ADJ
admet-317	17	45	fractions	fraction	NOUN
admet-317	17	46	for	for	ADP
admet-317	17	47	drug	drug	NOUN
admet-317	17	48	metabolism	metabolism	NOUN
admet-317	17	49	studies	study	NOUN
admet-317	17	50	as	as	SCONJ
admet-317	17	51	it	it	PRON
admet-317	17	52	is	be	AUX
admet-317	17	53	inexpensive	inexpensive	ADJ
admet-317	17	54	and	and	CCONJ
admet-317	17	55	easy	easy	ADJ
admet-317	17	56	to	to	PART
admet-317	17	57	handle	handle	VERB
admet-317	17	58	[	[	X
admet-317	17	59	4	4	NUM
admet-317	17	60	]	]	PUNCT
admet-317	17	61	.	.	PUNCT
admet-317	18	1	microsomal	microsomal	ADJ
admet-317	18	2	assays	assay	NOUN
admet-317	18	3	are	be	AUX
admet-317	18	4	the	the	DET
admet-317	18	5	default	default	NOUN
admet-317	18	6	assays	assay	NOUN
admet-317	18	7	for	for	ADP
admet-317	18	8	metabolism	metabolism	NOUN
admet-317	18	9	and	and	CCONJ
admet-317	18	10	ddi	ddi	PROPN
admet-317	18	11	studies	study	NOUN
admet-317	18	12	at	at	ADP
admet-317	18	13	the	the	DET
admet-317	18	14	drug	drug	NOUN
admet-317	18	15	discovery	discovery	NOUN
admet-317	18	16	stage	stage	NOUN
admet-317	18	17	[	[	X
admet-317	18	18	5	5	NUM
admet-317	18	19	]	]	PUNCT
admet-317	18	20	.	.	PUNCT
admet-317	19	1	in	in	ADP
admet-317	19	2	order	order	NOUN
admet-317	19	3	to	to	PART
admet-317	19	4	determine	determine	VERB
admet-317	19	5	intrinsic	intrinsic	ADJ
admet-317	19	6	clearance	clearance	NOUN
admet-317	19	7	of	of	ADP
admet-317	19	8	nces	nce	NOUN
admet-317	19	9	,	,	PUNCT
admet-317	19	10	which	which	PRON
admet-317	19	11	is	be	AUX
admet-317	19	12	a	a	DET
admet-317	19	13	useful	useful	ADJ
admet-317	19	14	parameter	parameter	NOUN
admet-317	19	15	for	for	ADP
admet-317	19	16	screening	screen	VERB
admet-317	19	17	process	process	NOUN
admet-317	19	18	of	of	ADP
admet-317	19	19	stable	stable	ADJ
admet-317	19	20	compounds	compound	NOUN
admet-317	19	21	and	and	CCONJ
admet-317	19	22	for	for	ADP
admet-317	19	23	establishing	establish	VERB
admet-317	19	24	an	an	DET
admet-317	19	25	in	in	ADP
admet-317	19	26	vitro	vitro	X
admet-317	19	27	correlation	correlation	NOUN
admet-317	19	28	between	between	ADP
admet-317	19	29	animals	animal	NOUN
admet-317	19	30	and	and	CCONJ
admet-317	19	31	humans	human	NOUN
admet-317	19	32	,	,	PUNCT
admet-317	19	33	microsomal	microsomal	ADJ
admet-317	19	34	assays	assay	NOUN
admet-317	19	35	play	play	VERB
admet-317	19	36	significant	significant	ADJ
admet-317	19	37	role	role	NOUN
admet-317	19	38	.	.	PUNCT
admet-317	20	1	in	in	ADP
admet-317	20	2	addition	addition	NOUN
admet-317	20	3	,	,	PUNCT
admet-317	20	4	this	this	PRON
admet-317	20	5	assay	assay	NOUN
admet-317	20	6	can	can	AUX
admet-317	20	7	also	also	ADV
admet-317	20	8	be	be	AUX
admet-317	20	9	utilized	utilize	VERB
admet-317	20	10	to	to	PART
admet-317	20	11	assess	assess	VERB
admet-317	20	12	extra	extra	ADJ
admet-317	20	13	-	-	ADJ
admet-317	20	14	hepatic	hepatic	ADJ
admet-317	20	15	metabolism	metabolism	NOUN
admet-317	20	16	and	and	CCONJ
admet-317	20	17	determine	determine	VERB
admet-317	20	18	the	the	DET
admet-317	20	19	ddi	ddi	ADJ
admet-317	20	20	potential	potential	NOUN
admet-317	20	21	of	of	ADP
admet-317	20	22	the	the	DET
admet-317	20	23	drug	drug	NOUN
admet-317	20	24	candidate	candidate	NOUN
admet-317	20	25	in	in	ADP
admet-317	20	26	preclinical	preclinical	ADJ
admet-317	20	27	phase	phase	NOUN
admet-317	20	28	[	[	X
admet-317	20	29	6	6	NUM
admet-317	20	30	]	]	PUNCT
admet-317	20	31	.	.	PUNCT
admet-317	21	1	apart	apart	ADV
admet-317	21	2	from	from	ADP
admet-317	21	3	liver	liver	NOUN
admet-317	21	4	,	,	PUNCT
admet-317	21	5	microsomes	microsome	NOUN
admet-317	21	6	can	can	AUX
admet-317	21	7	also	also	ADV
admet-317	21	8	be	be	AUX
admet-317	21	9	utilized	utilize	VERB
admet-317	21	10	to	to	PART
admet-317	21	11	focus	focus	VERB
admet-317	21	12	on	on	ADP
admet-317	21	13	the	the	DET
admet-317	21	14	region	region	NOUN
admet-317	21	15	-	-	PUNCT
admet-317	21	16	specific	specific	ADJ
admet-317	21	17	activity	activity	NOUN
admet-317	21	18	of	of	ADP
admet-317	21	19	the	the	DET
admet-317	21	20	intestinal	intestinal	ADJ
admet-317	21	21	enzymes	enzyme	NOUN
admet-317	21	22	.	.	PUNCT
admet-317	22	1	in	in	ADP
admet-317	22	2	general	general	ADJ
admet-317	22	3	,	,	PUNCT
admet-317	22	4	the	the	DET
admet-317	22	5	experimental	experimental	ADJ
admet-317	22	6	conditions	condition	NOUN
admet-317	22	7	utilizing	utilize	VERB
admet-317	22	8	microsomes	microsome	NOUN
admet-317	22	9	can	can	AUX
admet-317	22	10	be	be	AUX
admet-317	22	11	easily	easily	ADV
admet-317	22	12	controlled	control	VERB
admet-317	22	13	in	in	ADP
admet-317	22	14	comparison	comparison	NOUN
admet-317	22	15	to	to	ADP
admet-317	22	16	in	in	ADP
admet-317	22	17	vivo	vivo	NOUN
admet-317	22	18	and	and	CCONJ
admet-317	22	19	in	in	ADP
admet-317	22	20	situ	situ	ADJ
admet-317	22	21	models	model	NOUN
admet-317	22	22	.	.	PUNCT
admet-317	23	1	moreover	moreover	ADV
admet-317	23	2	,	,	PUNCT
admet-317	23	3	these	these	DET
admet-317	23	4	methods	method	NOUN
admet-317	23	5	are	be	AUX
admet-317	23	6	theoretically	theoretically	ADV
admet-317	23	7	applicable	applicable	ADJ
admet-317	23	8	to	to	ADP
admet-317	23	9	all	all	DET
admet-317	23	10	species	specie	NOUN
admet-317	23	11	and	and	CCONJ
admet-317	23	12	can	can	AUX
admet-317	23	13	be	be	AUX
admet-317	23	14	used	use	VERB
admet-317	23	15	to	to	PART
admet-317	23	16	study	study	VERB
admet-317	23	17	phase	phase	NOUN
admet-317	23	18	i	i	PRON
admet-317	23	19	and	and	CCONJ
admet-317	23	20	phase	phase	NOUN
admet-317	23	21	ii	ii	NOUN
admet-317	23	22	drug	drug	NOUN
admet-317	23	23	metabolism	metabolism	NOUN
admet-317	23	24	to	to	PART
admet-317	23	25	get	get	VERB
admet-317	23	26	the	the	DET
admet-317	23	27	enzyme	enzyme	NOUN
admet-317	23	28	isoforms	isoform	NOUN
admet-317	23	29	activity	activity	NOUN
admet-317	23	30	profile	profile	NOUN
admet-317	23	31	[	[	X
admet-317	23	32	7	7	NUM
admet-317	23	33	,	,	PUNCT
admet-317	23	34	8	8	NUM
admet-317	23	35	]	]	PUNCT
admet-317	23	36	.	.	PUNCT
admet-317	24	1	there	there	PRON
admet-317	24	2	are	be	VERB
admet-317	24	3	few	few	ADJ
admet-317	24	4	limitations	limitation	NOUN
admet-317	24	5	of	of	ADP
admet-317	24	6	microsomes	microsome	NOUN
admet-317	24	7	,	,	PUNCT
admet-317	24	8	for	for	ADP
admet-317	24	9	instance	instance	NOUN
admet-317	24	10	,	,	PUNCT
admet-317	24	11	they	they	PRON
admet-317	24	12	have	have	VERB
admet-317	24	13	to	to	PART
admet-317	24	14	be	be	AUX
admet-317	24	15	supplied	supply	VERB
admet-317	24	16	with	with	ADP
admet-317	24	17	co	co	NOUN
admet-317	24	18	-	-	NOUN
admet-317	24	19	factors	factor	NOUN
admet-317	24	20	like	like	ADP
admet-317	24	21	nadph	nadph	ADJ
admet-317	24	22	,	,	PUNCT
admet-317	24	23	or	or	CCONJ
admet-317	24	24	udpga	udpga	NOUN
admet-317	24	25	for	for	SCONJ
admet-317	24	26	the	the	DET
admet-317	24	27	metabolic	metabolic	NOUN
admet-317	24	28	reactions	reaction	NOUN
admet-317	24	29	to	to	PART
admet-317	24	30	initiate	initiate	VERB
admet-317	24	31	,	,	PUNCT
admet-317	24	32	and	and	CCONJ
admet-317	24	33	lack	lack	VERB
admet-317	24	34	the	the	DET
admet-317	24	35	cell	cell	NOUN
admet-317	24	36	membranes	membrane	NOUN
admet-317	24	37	to	to	PART
admet-317	24	38	mimic	mimic	VERB
admet-317	24	39	the	the	DET
admet-317	24	40	physiological	physiological	ADJ
admet-317	24	41	environment	environment	NOUN
admet-317	24	42	in	in	ADP
admet-317	24	43	hepatocytes	hepatocyte	NOUN
admet-317	25	1	[	[	X
admet-317	25	2	7	7	NUM
admet-317	25	3	,	,	PUNCT
admet-317	25	4	8	8	NUM
admet-317	25	5	]	]	PUNCT
admet-317	25	6	.	.	PUNCT
admet-317	26	1	in	in	ADP
admet-317	26	2	addition	addition	NOUN
admet-317	26	3	,	,	PUNCT
admet-317	26	4	it	it	PRON
admet-317	26	5	suffers	suffer	VERB
admet-317	26	6	from	from	ADP
admet-317	26	7	its	its	PRON
admet-317	26	8	non	non	ADJ
admet-317	26	9	-	-	ADJ
admet-317	26	10	physiological	physiological	ADJ
admet-317	26	11	nature	nature	NOUN
admet-317	26	12	due	due	ADP
admet-317	26	13	to	to	ADP
admet-317	26	14	the	the	DET
admet-317	26	15	absence	absence	NOUN
admet-317	26	16	of	of	ADP
admet-317	26	17	cellular	cellular	ADJ
admet-317	26	18	metabolism	metabolism	NOUN
admet-317	26	19	,	,	PUNCT
admet-317	26	20	membrane	membrane	NOUN
admet-317	26	21	transport	transport	NOUN
admet-317	26	22	and	and	CCONJ
admet-317	26	23	production	production	NOUN
admet-317	26	24	of	of	ADP
admet-317	26	25	co	co	NOUN
admet-317	26	26	-	-	NOUN
admet-317	26	27	factor	factor	NOUN
admet-317	26	28	[	[	NOUN
admet-317	26	29	3	3	NUM
admet-317	26	30	,	,	PUNCT
admet-317	26	31	9	9	NUM
admet-317	26	32	]	]	PUNCT
admet-317	26	33	.	.	PUNCT
admet-317	27	1	furthermore	furthermore	ADV
admet-317	27	2	,	,	PUNCT
admet-317	27	3	this	this	DET
admet-317	27	4	tissue	tissue	NOUN
admet-317	27	5	preparation	preparation	NOUN
admet-317	27	6	can	can	AUX
admet-317	27	7	not	not	PART
admet-317	27	8	provide	provide	VERB
admet-317	27	9	the	the	DET
admet-317	27	10	information	information	NOUN
admet-317	27	11	on	on	ADP
admet-317	27	12	the	the	DET
admet-317	27	13	activities	activity	NOUN
admet-317	27	14	of	of	ADP
admet-317	27	15	the	the	DET
admet-317	27	16	transporters	transporter	NOUN
admet-317	27	17	along	along	ADP
admet-317	27	18	the	the	DET
admet-317	27	19	intestine	intestine	NOUN
admet-317	27	20	,	,	PUNCT
admet-317	27	21	which	which	PRON
admet-317	27	22	can	can	AUX
admet-317	27	23	be	be	AUX
admet-317	27	24	critical	critical	ADJ
admet-317	27	25	for	for	ADP
admet-317	27	26	the	the	DET
admet-317	27	27	investigation	investigation	NOUN
admet-317	27	28	of	of	ADP
admet-317	27	29	gut	gut	NOUN
admet-317	27	30	metabolism	metabolism	NOUN
admet-317	27	31	to	to	PART
admet-317	27	32	rationalize	rationalize	VERB
admet-317	27	33	the	the	DET
admet-317	27	34	absorption	absorption	NOUN
admet-317	27	35	and	and	CCONJ
admet-317	27	36	permeability	permeability	NOUN
admet-317	27	37	of	of	ADP
admet-317	27	38	the	the	DET
admet-317	27	39	compound	compound	NOUN
admet-317	27	40	.	.	PUNCT
admet-317	28	1	the	the	DET
admet-317	28	2	preparations	preparation	NOUN
admet-317	28	3	of	of	ADP
admet-317	28	4	intestinal	intestinal	ADJ
admet-317	28	5	microsomes	microsome	NOUN
admet-317	28	6	are	be	AUX
admet-317	28	7	more	more	ADV
admet-317	28	8	prone	prone	ADJ
admet-317	28	9	to	to	ADP
admet-317	28	10	artefacts	artefact	NOUN
admet-317	28	11	in	in	ADP
admet-317	28	12	comparison	comparison	NOUN
admet-317	28	13	to	to	ADP
admet-317	28	14	the	the	DET
admet-317	28	15	preparation	preparation	NOUN
admet-317	28	16	of	of	ADP
admet-317	28	17	the	the	DET
admet-317	28	18	liver	liver	NOUN
admet-317	28	19	microsomes	microsome	NOUN
admet-317	28	20	.	.	PUNCT
admet-317	29	1	several	several	ADJ
admet-317	29	2	attempts	attempt	NOUN
admet-317	29	3	have	have	AUX
admet-317	29	4	been	be	AUX
admet-317	29	5	made	make	VERB
admet-317	29	6	to	to	PART
admet-317	29	7	reach	reach	VERB
admet-317	29	8	a	a	DET
admet-317	29	9	mid	mid	NOUN
admet-317	29	10	-	-	NOUN
admet-317	29	11	point	point	NOUN
admet-317	29	12	between	between	ADP
admet-317	29	13	the	the	DET
admet-317	29	14	physiological	physiological	ADJ
admet-317	29	15	complexity	complexity	NOUN
admet-317	29	16	and	and	CCONJ
admet-317	29	17	biochemical	biochemical	ADJ
admet-317	29	18	ease	ease	NOUN
admet-317	29	19	.	.	PUNCT
admet-317	30	1	for	for	ADP
admet-317	30	2	that	that	DET
admet-317	30	3	effort	effort	NOUN
admet-317	30	4	,	,	PUNCT
admet-317	30	5	liver	liver	NOUN
admet-317	30	6	slices	slice	NOUN
admet-317	30	7	as	as	ADV
admet-317	30	8	well	well	ADV
admet-317	30	9	as	as	ADP
admet-317	30	10	isolated	isolate	VERB
admet-317	30	11	cells	cell	NOUN
admet-317	30	12	have	have	AUX
admet-317	30	13	been	be	AUX
admet-317	30	14	used	use	VERB
admet-317	30	15	.	.	PUNCT
admet-317	31	1	liver	liver	NOUN
admet-317	31	2	slices	slice	NOUN
admet-317	31	3	have	have	VERB
admet-317	31	4	the	the	DET
admet-317	31	5	physiological	physiological	ADJ
admet-317	31	6	cell	cell	NOUN
admet-317	31	7	to	to	ADP
admet-317	31	8	cell	cell	NOUN
admet-317	31	9	contact	contact	NOUN
admet-317	31	10	needed	need	VERB
admet-317	31	11	for	for	ADP
admet-317	31	12	the	the	DET
admet-317	31	13	liver	liver	NOUN
admet-317	31	14	preparation	preparation	NOUN
admet-317	31	15	but	but	CCONJ
admet-317	31	16	are	be	AUX
admet-317	31	17	somewhat	somewhat	ADV
admet-317	31	18	unsatisfactory	unsatisfactory	ADJ
admet-317	31	19	due	due	ADP
admet-317	31	20	to	to	ADP
admet-317	31	21	the	the	DET
admet-317	31	22	inability	inability	NOUN
admet-317	31	23	to	to	PART
admet-317	31	24	get	get	VERB
admet-317	31	25	access	access	NOUN
admet-317	31	26	of	of	ADP
admet-317	31	27	the	the	DET
admet-317	31	28	substrate	substrate	NOUN
admet-317	31	29	and	and	CCONJ
admet-317	31	30	nutrient	nutrient	NOUN
admet-317	31	31	to	to	ADP
admet-317	31	32	the	the	DET
admet-317	31	33	centre	centre	NOUN
admet-317	31	34	of	of	ADP
admet-317	31	35	the	the	DET
admet-317	31	36	preparation	preparation	NOUN
admet-317	31	37	.	.	PUNCT
admet-317	32	1	in	in	ADP
admet-317	32	2	comparison	comparison	NOUN
admet-317	32	3	,	,	PUNCT
admet-317	32	4	isolated	isolate	VERB
admet-317	32	5	liver	liver	NOUN
admet-317	32	6	cells	cell	NOUN
admet-317	32	7	are	be	AUX
admet-317	32	8	regarded	regard	VERB
admet-317	32	9	as	as	ADP
admet-317	32	10	the	the	DET
admet-317	32	11	best	good	ADJ
admet-317	32	12	alternate	alternate	NOUN
admet-317	32	13	,	,	PUNCT
admet-317	32	14	as	as	SCONJ
admet-317	32	15	they	they	PRON
admet-317	32	16	can	can	AUX
admet-317	32	17	be	be	AUX
admet-317	32	18	stored	store	VERB
admet-317	32	19	in	in	ADP
admet-317	32	20	cultures	culture	NOUN
admet-317	32	21	for	for	ADP
admet-317	32	22	extended	extended	ADJ
admet-317	32	23	periods	period	NOUN
admet-317	32	24	of	of	ADP
admet-317	32	25	time	time	NOUN
admet-317	32	26	without	without	ADP
admet-317	32	27	losing	lose	VERB
admet-317	32	28	their	their	PRON
admet-317	32	29	differentiated	differentiated	ADJ
admet-317	32	30	functions	function	NOUN
admet-317	32	31	.	.	PUNCT
admet-317	33	1	due	due	ADP
admet-317	33	2	to	to	ADP
admet-317	33	3	the	the	DET
admet-317	33	4	presence	presence	NOUN
admet-317	33	5	of	of	ADP
admet-317	33	6	various	various	ADJ
admet-317	33	7	uptake	uptake	NOUN
admet-317	33	8	or	or	CCONJ
admet-317	33	9	efflux	efflux	VERB
admet-317	33	10	transporters	transporter	NOUN
admet-317	33	11	in	in	ADP
admet-317	33	12	hepatocyte	hepatocyte	NOUN
admet-317	33	13	cell	cell	NOUN
admet-317	33	14	membranes	membrane	NOUN
admet-317	33	15	,	,	PUNCT
admet-317	33	16	this	this	DET
admet-317	33	17	particular	particular	ADJ
admet-317	33	18	subcellular	subcellular	ADJ
admet-317	33	19	fraction	fraction	NOUN
admet-317	33	20	can	can	AUX
admet-317	33	21	be	be	AUX
admet-317	33	22	used	use	VERB
admet-317	33	23	to	to	PART
admet-317	33	24	determine	determine	VERB
admet-317	33	25	the	the	DET
admet-317	33	26	role	role	NOUN
admet-317	33	27	of	of	ADP
admet-317	33	28	transporter	transporter	NOUN
admet-317	33	29	on	on	ADP
admet-317	33	30	the	the	DET
admet-317	33	31	disposition	disposition	NOUN
admet-317	33	32	of	of	ADP
admet-317	33	33	nce	nce	NOUN
admet-317	33	34	in	in	ADP
admet-317	33	35	preclinical	preclinical	ADJ
admet-317	33	36	discovery	discovery	NOUN
admet-317	33	37	phase	phase	NOUN
admet-317	33	38	.	.	PUNCT
admet-317	34	1	the	the	DET
admet-317	34	2	primary	primary	ADJ
admet-317	34	3	culture	culture	NOUN
admet-317	34	4	of	of	ADP
admet-317	34	5	hepatocytes	hepatocytes	PROPN
admet-317	34	6	provides	provide	VERB
admet-317	34	7	a	a	DET
admet-317	34	8	physiological	physiological	ADJ
admet-317	34	9	environment	environment	NOUN
admet-317	34	10	that	that	PRON
admet-317	34	11	closely	closely	ADV
admet-317	34	12	mimics	mimic	VERB
admet-317	34	13	the	the	DET
admet-317	34	14	in	in	ADP
admet-317	34	15	vivo	vivo	ADJ
admet-317	34	16	conditions	condition	NOUN
admet-317	34	17	as	as	SCONJ
admet-317	34	18	it	it	PRON
admet-317	34	19	contains	contain	VERB
admet-317	34	20	enzyme	enzyme	NOUN
admet-317	34	21	and	and	CCONJ
admet-317	34	22	co	co	NOUN
admet-317	34	23	-	-	NOUN
admet-317	34	24	factors	factor	NOUN
admet-317	34	25	at	at	ADP
admet-317	34	26	physiological	physiological	ADJ
admet-317	34	27	concentrations	concentration	NOUN
admet-317	34	28	.	.	PUNCT
admet-317	35	1	in	in	ADP
admet-317	35	2	drug	drug	NOUN
admet-317	35	3	discovery	discovery	NOUN
admet-317	35	4	,	,	PUNCT
admet-317	35	5	hepatocytes	hepatocyte	NOUN
admet-317	35	6	are	be	AUX
admet-317	35	7	mainly	mainly	ADV
admet-317	35	8	used	use	VERB
admet-317	35	9	as	as	ADP
admet-317	35	10	sandwich	sandwich	NOUN
admet-317	35	11	cultures	culture	NOUN
admet-317	35	12	or	or	CCONJ
admet-317	35	13	suspensions	suspension	NOUN
admet-317	35	14	which	which	PRON
admet-317	35	15	are	be	AUX
admet-317	35	16	primarily	primarily	ADV
admet-317	35	17	used	use	VERB
admet-317	35	18	for	for	ADP
admet-317	35	19	the	the	DET
admet-317	35	20	study	study	NOUN
admet-317	35	21	of	of	ADP
admet-317	35	22	metabolic	metabolic	NOUN
admet-317	35	23	stability	stability	NOUN
admet-317	35	24	or	or	CCONJ
admet-317	35	25	transporter	transporter	NOUN
admet-317	35	26	-	-	PUNCT
admet-317	35	27	mediated	mediate	VERB
admet-317	35	28	uptake	uptake	NOUN
admet-317	35	29	of	of	ADP
admet-317	35	30	drug	drug	NOUN
admet-317	35	31	candidates	candidate	NOUN
admet-317	35	32	.	.	PUNCT
admet-317	36	1	like	like	ADP
admet-317	36	2	microsomes	microsome	NOUN
admet-317	36	3	,	,	PUNCT
admet-317	36	4	hepatocytes	hepatocyte	NOUN
admet-317	36	5	can	can	AUX
admet-317	36	6	also	also	ADV
admet-317	36	7	be	be	AUX
admet-317	36	8	used	use	VERB
admet-317	36	9	in	in	ADP
admet-317	36	10	ddi	ddi	ADJ
admet-317	36	11	predictions	prediction	NOUN
admet-317	36	12	and	and	CCONJ
admet-317	36	13	in	in	ADP
admet-317	36	14	determining	determine	VERB
admet-317	36	15	intrinsic	intrinsic	ADJ
admet-317	36	16	clearance	clearance	NOUN
admet-317	36	17	.	.	PUNCT
admet-317	37	1	however	however	ADV
admet-317	37	2	,	,	PUNCT
admet-317	37	3	the	the	DET
admet-317	37	4	major	major	ADJ
admet-317	37	5	application	application	NOUN
admet-317	37	6	of	of	ADP
admet-317	37	7	cultured	cultured	ADJ
admet-317	37	8	hepatocytes	hepatocyte	NOUN
admet-317	37	9	is	be	AUX
admet-317	37	10	in	in	ADP
admet-317	37	11	cyp	cyp	ADJ
admet-317	37	12	induction	induction	NOUN
admet-317	37	13	studies	study	NOUN
admet-317	37	14	as	as	SCONJ
admet-317	37	15	enzyme	enzyme	NOUN
admet-317	37	16	induction	induction	NOUN
admet-317	37	17	may	may	AUX
admet-317	37	18	involve	involve	VERB
admet-317	37	19	gene	gene	NOUN
admet-317	37	20	transcription	transcription	NOUN
admet-317	37	21	and	and	CCONJ
admet-317	37	22	translation	translation	NOUN
admet-317	38	1	[	[	X
admet-317	38	2	10	10	NUM
admet-317	38	3	]	]	PUNCT
admet-317	38	4	.	.	PUNCT
admet-317	39	1	despite	despite	SCONJ
admet-317	39	2	hepatocytes	hepatocyte	NOUN
admet-317	39	3	playing	play	VERB
admet-317	39	4	a	a	DET
admet-317	39	5	significant	significant	ADJ
admet-317	39	6	role	role	NOUN
admet-317	39	7	in	in	ADP
admet-317	39	8	drug	drug	NOUN
admet-317	39	9	discovery	discovery	NOUN
admet-317	39	10	,	,	PUNCT
admet-317	39	11	their	their	PRON
admet-317	39	12	application	application	NOUN
admet-317	39	13	is	be	AUX
admet-317	39	14	to	to	ADP
admet-317	39	15	some	some	DET
admet-317	39	16	extent	extent	NOUN
admet-317	39	17	limited	limit	VERB
admet-317	39	18	because	because	SCONJ
admet-317	39	19	they	they	PRON
admet-317	39	20	are	be	AUX
admet-317	39	21	not	not	PART
admet-317	39	22	readily	readily	ADV
admet-317	39	23	available	available	ADJ
admet-317	39	24	and	and	CCONJ
admet-317	39	25	difficult	difficult	ADJ
admet-317	39	26	to	to	PART
admet-317	39	27	reproduce	reproduce	VERB
admet-317	39	28	the	the	DET
admet-317	39	29	results	result	NOUN
admet-317	39	30	due	due	ADP
admet-317	39	31	to	to	ADP
admet-317	39	32	high	high	ADJ
admet-317	39	33	inter	inter	ADJ
admet-317	39	34	individual	individual	ADJ
admet-317	39	35	variability	variability	NOUN
admet-317	39	36	between	between	ADP
admet-317	39	37	human	human	ADJ
admet-317	39	38	liver	liver	NOUN
admet-317	39	39	donors	donor	NOUN
admet-317	39	40	.	.	PUNCT
admet-317	40	1	of	of	ADP
admet-317	40	2	late	late	ADV
admet-317	40	3	,	,	PUNCT
admet-317	40	4	freshly	freshly	ADV
admet-317	40	5	isolated	isolate	VERB
admet-317	40	6	,	,	PUNCT
admet-317	40	7	pooled	pool	VERB
admet-317	40	8	cryopreserved	cryopreserve	VERB
admet-317	40	9	hepatocytes	hepatocyte	NOUN
admet-317	40	10	are	be	AUX
admet-317	40	11	being	be	AUX
admet-317	40	12	used	use	VERB
admet-317	40	13	to	to	PART
admet-317	40	14	circumvent	circumvent	VERB
admet-317	40	15	this	this	DET
admet-317	40	16	problem	problem	NOUN
admet-317	40	17	which	which	PRON
admet-317	40	18	allows	allow	VERB
admet-317	40	19	researchers	researcher	NOUN
admet-317	40	20	to	to	PART
admet-317	40	21	use	use	VERB
admet-317	40	22	the	the	DET
admet-317	40	23	same	same	ADJ
admet-317	40	24	lot	lot	NOUN
admet-317	40	25	of	of	ADP
admet-317	40	26	cells	cell	NOUN
admet-317	40	27	over	over	ADP
admet-317	40	28	a	a	DET
admet-317	40	29	period	period	NOUN
admet-317	40	30	of	of	ADP
admet-317	40	31	time	time	NOUN
admet-317	40	32	.	.	PUNCT
admet-317	41	1	however	however	ADV
admet-317	41	2	,	,	PUNCT
admet-317	41	3	improving	improve	VERB
admet-317	41	4	long	long	ADJ
admet-317	41	5	term	term	NOUN
admet-317	41	6	culture	culture	NOUN
admet-317	41	7	of	of	ADP
admet-317	41	8	hepatocyte	hepatocyte	NOUN
admet-317	41	9	has	have	AUX
admet-317	41	10	been	be	AUX
admet-317	41	11	an	an	DET
admet-317	41	12	area	area	NOUN
admet-317	41	13	of	of	ADP
admet-317	41	14	research	research	NOUN
admet-317	41	15	focus	focus	NOUN
admet-317	41	16	in	in	ADP
admet-317	41	17	the	the	DET
admet-317	41	18	last	last	ADJ
admet-317	41	19	decade	decade	NOUN
admet-317	41	20	.	.	PUNCT
admet-317	42	1	in	in	ADP
admet-317	42	2	the	the	DET
admet-317	42	3	cell	cell	NOUN
admet-317	42	4	system	system	NOUN
admet-317	42	5	,	,	PUNCT
admet-317	42	6	drugs	drug	NOUN
admet-317	42	7	never	never	ADV
admet-317	42	8	have	have	VERB
admet-317	42	9	easy	easy	ADJ
admet-317	42	10	access	access	NOUN
admet-317	42	11	to	to	ADP
admet-317	42	12	the	the	DET
admet-317	42	13	drug	drug	NOUN
admet-317	42	14	metabolizing	metabolize	VERB
admet-317	42	15	enzymes	enzyme	NOUN
admet-317	42	16	.	.	PUNCT
admet-317	43	1	they	they	PRON
admet-317	43	2	have	have	VERB
admet-317	43	3	to	to	PART
admet-317	43	4	pass	pass	VERB
admet-317	43	5	through	through	ADP
admet-317	43	6	barriers	barrier	NOUN
admet-317	43	7	containing	contain	VERB
admet-317	43	8	drug	drug	NOUN
admet-317	43	9	transporters	transporter	NOUN
admet-317	43	10	which	which	PRON
admet-317	43	11	facilitate	facilitate	VERB
admet-317	43	12	the	the	DET
admet-317	43	13	movement	movement	NOUN
admet-317	43	14	of	of	ADP
admet-317	43	15	these	these	DET
admet-317	43	16	drugs	drug	NOUN
admet-317	43	17	across	across	ADP
admet-317	43	18	the	the	DET
admet-317	43	19	membrane	membrane	NOUN
admet-317	43	20	either	either	CCONJ
admet-317	43	21	concentrating	concentrate	VERB
admet-317	43	22	the	the	DET
admet-317	43	23	cell	cell	NOUN
admet-317	43	24	via	via	ADP
admet-317	43	25	influx	influx	NOUN
admet-317	43	26	transporters	transporter	NOUN
admet-317	43	27	,	,	PUNCT
admet-317	43	28	or	or	CCONJ
admet-317	43	29	dispersing	disperse	VERB
admet-317	43	30	the	the	DET
admet-317	43	31	drug	drug	NOUN
admet-317	43	32	through	through	ADP
admet-317	43	33	efflux	efflux	NOUN
admet-317	43	34	transporters	transporter	NOUN
admet-317	43	35	denying	deny	VERB
admet-317	43	36	access	access	NOUN
admet-317	43	37	of	of	ADP
admet-317	43	38	enzymes	enzyme	NOUN
admet-317	43	39	to	to	ADP
admet-317	43	40	the	the	DET
admet-317	43	41	drug	drug	NOUN
admet-317	43	42	[	[	X
admet-317	43	43	11	11	NUM
admet-317	43	44	]	]	PUNCT
admet-317	43	45	.	.	PUNCT
admet-317	44	1	due	due	ADP
admet-317	44	2	to	to	ADP
admet-317	44	3	the	the	DET
admet-317	44	4	involvement	involvement	NOUN
admet-317	44	5	of	of	ADP
admet-317	44	6	these	these	DET
admet-317	44	7	drug	drug	NOUN
admet-317	44	8	transporters	transporter	NOUN
admet-317	44	9	,	,	PUNCT
admet-317	44	10	in	in	ADP
admet-317	44	11	drug	drug	NOUN
admet-317	44	12	disposition	disposition	NOUN
admet-317	44	13	and	and	CCONJ
admet-317	44	14	ddis	ddi	NOUN
admet-317	44	15	,	,	PUNCT
admet-317	44	16	there	there	PRON
admet-317	44	17	has	have	AUX
admet-317	44	18	been	be	AUX
admet-317	44	19	major	major	ADJ
admet-317	44	20	interest	interest	NOUN
admet-317	44	21	in	in	ADP
admet-317	44	22	the	the	DET
admet-317	44	23	past	past	ADJ
admet-317	44	24	decade	decade	NOUN
admet-317	44	25	to	to	PART
admet-317	44	26	study	study	VERB
admet-317	44	27	the	the	DET
admet-317	44	28	role	role	NOUN
admet-317	44	29	of	of	ADP
admet-317	44	30	these	these	DET
admet-317	44	31	transporters	transporter	NOUN
admet-317	44	32	in	in	ADP
admet-317	44	33	drug	drug	NOUN
admet-317	44	34	discovery	discovery	NOUN
admet-317	44	35	and	and	CCONJ
admet-317	44	36	development	development	NOUN
admet-317	44	37	.	.	PUNCT
admet-317	45	1	hepatocytes	hepatocytes	PROPN
admet-317	45	2	have	have	VERB
admet-317	45	3	a	a	DET
admet-317	45	4	cellular	cellular	ADJ
admet-317	45	5	organization	organization	NOUN
admet-317	45	6	basu	basu	PROPN
admet-317	45	7	and	and	CCONJ
admet-317	45	8	shaik	shaik	PROPN
admet-317	45	9	admet	admet	PROPN
admet-317	45	10	&	&	CCONJ
admet-317	45	11	dmpk	dmpk	PROPN
admet-317	45	12	4(2	4(2	NUM
admet-317	45	13	)	)	PUNCT
admet-317	45	14	(	(	PUNCT
admet-317	45	15	2016	2016	NUM
admet-317	45	16	)	)	PUNCT
admet-317	45	17	114	114	NUM
admet-317	45	18	-	-	SYM
admet-317	45	19	116	116	NUM
admet-317	45	20	116	116	NUM
admet-317	45	21	containing	contain	VERB
admet-317	45	22	the	the	DET
admet-317	45	23	necessary	necessary	ADJ
admet-317	45	24	co	co	NOUN
admet-317	45	25	-	-	NOUN
admet-317	45	26	factors	factor	NOUN
admet-317	45	27	and	and	CCONJ
admet-317	45	28	membranes	membrane	NOUN
admet-317	45	29	transporters	transporter	NOUN
admet-317	45	30	,	,	PUNCT
admet-317	45	31	which	which	PRON
admet-317	45	32	represent	represent	VERB
admet-317	45	33	a	a	DET
admet-317	45	34	more	more	ADV
admet-317	45	35	complete	complete	ADJ
admet-317	45	36	system	system	NOUN
admet-317	45	37	to	to	PART
admet-317	45	38	study	study	VERB
admet-317	45	39	drug	drug	NOUN
admet-317	45	40	metabolism	metabolism	NOUN
admet-317	45	41	.	.	PUNCT
admet-317	46	1	due	due	ADP
admet-317	46	2	to	to	ADP
admet-317	46	3	the	the	DET
admet-317	46	4	high	high	ADJ
admet-317	46	5	cost	cost	NOUN
admet-317	46	6	and	and	CCONJ
admet-317	46	7	the	the	DET
admet-317	46	8	complexity	complexity	NOUN
admet-317	46	9	in	in	ADP
admet-317	46	10	conducting	conduct	VERB
admet-317	46	11	experiments	experiment	NOUN
admet-317	46	12	with	with	ADP
admet-317	46	13	hepatocytes	hepatocyte	NOUN
admet-317	46	14	,	,	PUNCT
admet-317	46	15	microsomes	microsome	NOUN
admet-317	46	16	still	still	ADV
admet-317	46	17	remain	remain	VERB
admet-317	46	18	the	the	DET
admet-317	46	19	tool	tool	NOUN
admet-317	46	20	of	of	ADP
admet-317	46	21	choice	choice	NOUN
admet-317	46	22	for	for	ADP
admet-317	46	23	early	early	ADJ
admet-317	46	24	drug	drug	NOUN
admet-317	46	25	discovery	discovery	NOUN
admet-317	46	26	studies	study	NOUN
admet-317	46	27	.	.	PUNCT
admet-317	47	1	due	due	ADP
admet-317	47	2	to	to	ADP
admet-317	47	3	the	the	DET
admet-317	47	4	advancement	advancement	NOUN
admet-317	47	5	of	of	ADP
admet-317	47	6	technology	technology	NOUN
admet-317	47	7	,	,	PUNCT
admet-317	47	8	commercial	commercial	ADJ
admet-317	47	9	companies	company	NOUN
admet-317	47	10	and	and	CCONJ
admet-317	47	11	research	research	NOUN
admet-317	47	12	organizations	organization	NOUN
admet-317	47	13	can	can	AUX
admet-317	47	14	now	now	ADV
admet-317	47	15	obtain	obtain	VERB
admet-317	47	16	human	human	ADJ
admet-317	47	17	livers	liver	NOUN
admet-317	47	18	,	,	PUNCT
admet-317	47	19	make	make	VERB
admet-317	47	20	and	and	CCONJ
admet-317	47	21	store	store	VERB
admet-317	47	22	deep	deep	ADJ
admet-317	47	23	frozen	frozen	ADJ
admet-317	47	24	slices	slice	NOUN
admet-317	47	25	and	and	CCONJ
admet-317	47	26	isolated	isolated	ADJ
admet-317	47	27	hepatocytes	hepatocyte	NOUN
admet-317	47	28	in	in	ADP
admet-317	47	29	research	research	NOUN
admet-317	47	30	and	and	CCONJ
admet-317	47	31	drug	drug	NOUN
admet-317	47	32	testing	testing	NOUN
admet-317	47	33	.	.	PUNCT
admet-317	48	1	from	from	ADP
admet-317	48	2	the	the	DET
admet-317	48	3	literature	literature	NOUN
admet-317	48	4	studies	study	NOUN
admet-317	48	5	it	it	PRON
admet-317	48	6	is	be	AUX
admet-317	48	7	quite	quite	ADV
admet-317	48	8	evident	evident	ADJ
admet-317	48	9	that	that	SCONJ
admet-317	48	10	instead	instead	ADV
admet-317	48	11	of	of	ADP
admet-317	48	12	following	follow	VERB
admet-317	48	13	a	a	DET
admet-317	48	14	general	general	ADJ
admet-317	48	15	method	method	NOUN
admet-317	48	16	to	to	PART
admet-317	48	17	procure	procure	VERB
admet-317	48	18	and	and	CCONJ
admet-317	48	19	utilizing	utilize	VERB
admet-317	48	20	the	the	DET
admet-317	48	21	tissue	tissue	NOUN
admet-317	48	22	,	,	PUNCT
admet-317	48	23	a	a	DET
admet-317	48	24	case	case	NOUN
admet-317	48	25	by	by	ADP
admet-317	48	26	case	case	NOUN
admet-317	48	27	approach	approach	NOUN
admet-317	48	28	has	have	AUX
admet-317	48	29	always	always	ADV
admet-317	48	30	been	be	AUX
admet-317	48	31	taken	take	VERB
admet-317	48	32	depending	depend	VERB
admet-317	48	33	on	on	ADP
admet-317	48	34	what	what	PRON
admet-317	48	35	kind	kind	NOUN
admet-317	48	36	of	of	ADP
admet-317	48	37	questions	question	NOUN
admet-317	48	38	we	we	PRON
admet-317	48	39	would	would	AUX
admet-317	48	40	like	like	VERB
admet-317	48	41	to	to	PART
admet-317	48	42	answer	answer	VERB
admet-317	48	43	,	,	PUNCT
admet-317	48	44	physiological	physiological	ADJ
admet-317	48	45	or	or	CCONJ
admet-317	48	46	biochemical	biochemical	ADJ
admet-317	48	47	.	.	PUNCT
admet-317	49	1	for	for	ADP
admet-317	49	2	an	an	DET
admet-317	49	3	example	example	NOUN
admet-317	49	4	,	,	PUNCT
admet-317	49	5	in	in	ADP
admet-317	49	6	order	order	NOUN
admet-317	49	7	to	to	PART
admet-317	49	8	measure	measure	VERB
admet-317	49	9	the	the	DET
admet-317	49	10	change	change	NOUN
admet-317	49	11	of	of	ADP
admet-317	49	12	phase	phase	NOUN
admet-317	49	13	i	i	PRON
admet-317	49	14	or	or	CCONJ
admet-317	49	15	ii	ii	NOUN
admet-317	49	16	drug	drug	NOUN
admet-317	49	17	metabolizing	metabolize	VERB
admet-317	49	18	enzyme	enzyme	NOUN
admet-317	49	19	content	content	NOUN
admet-317	49	20	,	,	PUNCT
admet-317	49	21	the	the	DET
admet-317	49	22	usage	usage	NOUN
admet-317	49	23	of	of	ADP
admet-317	49	24	microsomes	microsome	NOUN
admet-317	49	25	or	or	CCONJ
admet-317	49	26	other	other	ADJ
admet-317	49	27	subcellular	subcellular	ADJ
admet-317	49	28	fraction	fraction	NOUN
admet-317	49	29	is	be	AUX
admet-317	49	30	appropriate	appropriate	ADJ
admet-317	49	31	.	.	PUNCT
admet-317	50	1	on	on	ADP
admet-317	50	2	the	the	DET
admet-317	50	3	other	other	ADJ
admet-317	50	4	hand	hand	NOUN
admet-317	50	5	,	,	PUNCT
admet-317	50	6	to	to	PART
admet-317	50	7	assess	assess	VERB
admet-317	50	8	the	the	DET
admet-317	50	9	impact	impact	NOUN
admet-317	50	10	of	of	ADP
admet-317	50	11	transporters	transporter	NOUN
admet-317	50	12	on	on	ADP
admet-317	50	13	the	the	DET
admet-317	50	14	disposition	disposition	NOUN
admet-317	50	15	of	of	ADP
admet-317	50	16	nces	nce	NOUN
admet-317	50	17	in	in	ADP
admet-317	50	18	discovery	discovery	NOUN
admet-317	50	19	phase	phase	NOUN
admet-317	50	20	as	as	ADV
admet-317	50	21	well	well	ADV
admet-317	50	22	as	as	ADP
admet-317	50	23	to	to	PART
admet-317	50	24	investigate	investigate	VERB
admet-317	50	25	the	the	DET
admet-317	50	26	presence	presence	NOUN
admet-317	50	27	or	or	CCONJ
admet-317	50	28	nature	nature	NOUN
admet-317	50	29	of	of	ADP
admet-317	50	30	hepatotoxicity	hepatotoxicity	NOUN
admet-317	50	31	,	,	PUNCT
admet-317	50	32	hepatocytes	hepatocyte	NOUN
admet-317	50	33	or	or	CCONJ
admet-317	50	34	whole	whole	ADJ
admet-317	50	35	liver	liver	NOUN
admet-317	50	36	preparation	preparation	NOUN
admet-317	50	37	will	will	AUX
admet-317	50	38	be	be	AUX
admet-317	50	39	more	more	ADV
admet-317	50	40	useful	useful	ADJ
admet-317	50	41	.	.	PUNCT
admet-317	51	1	reverting	revert	VERB
admet-317	51	2	back	back	ADV
admet-317	51	3	to	to	ADP
admet-317	51	4	the	the	DET
admet-317	51	5	title	title	NOUN
admet-317	51	6	of	of	ADP
admet-317	51	7	this	this	DET
admet-317	51	8	opinion	opinion	NOUN
admet-317	51	9	“	"	PUNCT
admet-317	51	10	is	be	AUX
admet-317	51	11	there	there	PRON
admet-317	51	12	a	a	DET
admet-317	51	13	paradigm	paradigm	NOUN
admet-317	51	14	shift	shift	NOUN
admet-317	51	15	in	in	ADP
admet-317	51	16	use	use	NOUN
admet-317	51	17	of	of	ADP
admet-317	51	18	microsomes	microsome	NOUN
admet-317	51	19	and	and	CCONJ
admet-317	51	20	hepatocytes	hepatocyte	NOUN
admet-317	51	21	in	in	ADP
admet-317	51	22	drug	drug	NOUN
admet-317	51	23	discovery	discovery	NOUN
admet-317	51	24	and	and	CCONJ
admet-317	51	25	development	development	NOUN
admet-317	51	26	?	?	PUNCT
admet-317	51	27	”	"	PUNCT
admet-317	51	28	;	;	PUNCT
admet-317	51	29	based	base	VERB
admet-317	51	30	on	on	ADP
admet-317	51	31	the	the	DET
admet-317	51	32	literature	literature	NOUN
admet-317	51	33	,	,	PUNCT
admet-317	51	34	even	even	ADV
admet-317	51	35	though	though	SCONJ
admet-317	51	36	utilization	utilization	NOUN
admet-317	51	37	of	of	ADP
admet-317	51	38	hepatocytes	hepatocyte	NOUN
admet-317	51	39	in	in	ADP
admet-317	51	40	drug	drug	NOUN
admet-317	51	41	discovery	discovery	NOUN
admet-317	51	42	and	and	CCONJ
admet-317	51	43	development	development	NOUN
admet-317	51	44	has	have	AUX
admet-317	51	45	been	be	AUX
admet-317	51	46	increasing	increase	VERB
admet-317	51	47	in	in	ADP
admet-317	51	48	the	the	DET
admet-317	51	49	last	last	ADJ
admet-317	51	50	decade	decade	NOUN
admet-317	51	51	,	,	PUNCT
admet-317	51	52	the	the	DET
admet-317	51	53	choice	choice	NOUN
admet-317	51	54	of	of	ADP
admet-317	51	55	in	in	ADP
admet-317	51	56	vitro	vitro	X
admet-317	51	57	tool	tool	NOUN
admet-317	51	58	mainly	mainly	ADV
admet-317	51	59	depends	depend	VERB
admet-317	51	60	on	on	ADP
admet-317	51	61	the	the	DET
admet-317	51	62	type	type	NOUN
admet-317	51	63	of	of	ADP
admet-317	51	64	study	study	NOUN
admet-317	51	65	performed	perform	VERB
admet-317	51	66	.	.	PUNCT
admet-317	52	1	references	reference	NOUN
admet-317	52	2	[	[	X
admet-317	52	3	1	1	NUM
admet-317	52	4	]	]	X
admet-317	52	5	a.s	a.s	PROPN
admet-317	52	6	.	.	PROPN
admet-317	52	7	kalgutkar	kalgutkar	PROPN
admet-317	52	8	,	,	PUNCT
admet-317	52	9	r.s	r.s	PROPN
admet-317	52	10	.	.	PROPN
admet-317	52	11	obach	obach	PROPN
admet-317	52	12	,	,	PUNCT
admet-317	52	13	t.s	t.s	PROPN
admet-317	52	14	.	.	PROPN
admet-317	52	15	maurer	maurer	PROPN
admet-317	52	16	,	,	PUNCT
admet-317	52	17	current	current	ADJ
admet-317	52	18	drug	drug	NOUN
admet-317	52	19	metabolism	metabolism	NOUN
admet-317	52	20	8	8	NUM
admet-317	52	21	(	(	PUNCT
admet-317	52	22	2007	2007	NUM
admet-317	52	23	)	)	PUNCT
admet-317	52	24	407	407	NUM
admet-317	52	25	-	-	SYM
admet-317	52	26	447	447	NUM
admet-317	52	27	.	.	PUNCT
admet-317	53	1	[	[	X
admet-317	53	2	2	2	NUM
admet-317	53	3	]	]	X
admet-317	53	4	a.n	a.n	PROPN
admet-317	53	5	.	.	PROPN
admet-317	53	6	shaik	shaik	PROPN
admet-317	53	7	,	,	PUNCT
admet-317	53	8	t.	t.	PROPN
admet-317	53	9	bohnert	bohnert	NOUN
admet-317	53	10	,	,	PUNCT
admet-317	53	11	d.a	d.a	PROPN
admet-317	53	12	.	.	PROPN
admet-317	53	13	williams	williams	PROPN
admet-317	53	14	,	,	PUNCT
admet-317	53	15	l.l	l.l	PROPN
admet-317	53	16	.	.	PROPN
admet-317	53	17	gan	gan	PROPN
admet-317	53	18	,	,	PUNCT
admet-317	53	19	b.w	b.w	PROPN
admet-317	53	20	.	.	PROPN
admet-317	53	21	leduc	leduc	PROPN
admet-317	53	22	,	,	PUNCT
admet-317	53	23	journal	journal	NOUN
admet-317	53	24	of	of	ADP
admet-317	53	25	pharmaceutical	pharmaceutical	PROPN
admet-317	53	26	sciences	science	NOUN
admet-317	53	27	105	105	NUM
admet-317	53	28	(	(	PUNCT
admet-317	53	29	2016	2016	NUM
admet-317	53	30	)	)	PUNCT
admet-317	53	31	1976	1976	NUM
admet-317	53	32	-	-	SYM
admet-317	53	33	1986	1986	NUM
admet-317	53	34	.	.	PUNCT
admet-317	54	1	[	[	X
admet-317	54	2	3	3	X
admet-317	54	3	]	]	X
admet-317	54	4	r.s	r.s	PROPN
admet-317	54	5	.	.	PROPN
admet-317	54	6	obach	obach	PROPN
admet-317	54	7	,	,	PUNCT
admet-317	54	8	drug	drug	NOUN
admet-317	54	9	metabolism	metabolism	NOUN
admet-317	54	10	and	and	CCONJ
admet-317	54	11	disposition	disposition	NOUN
admet-317	54	12	:	:	PUNCT
admet-317	54	13	the	the	DET
admet-317	54	14	biological	biological	ADJ
admet-317	54	15	fate	fate	NOUN
admet-317	54	16	of	of	ADP
admet-317	54	17	chemicals	chemical	NOUN
admet-317	54	18	27	27	NUM
admet-317	54	19	(	(	PUNCT
admet-317	54	20	1999	1999	NUM
admet-317	54	21	)	)	PUNCT
admet-317	54	22	1350	1350	NUM
admet-317	54	23	-	-	SYM
admet-317	54	24	1359	1359	NUM
admet-317	54	25	.	.	PUNCT
admet-317	55	1	[	[	X
admet-317	55	2	4	4	X
admet-317	55	3	]	]	X
admet-317	55	4	d.	d.	PROPN
admet-317	55	5	zhang	zhang	PROPN
admet-317	55	6	,	,	PUNCT
admet-317	55	7	g.	g.	PROPN
admet-317	55	8	luo	luo	PROPN
admet-317	55	9	,	,	PUNCT
admet-317	55	10	x.	x.	PROPN
admet-317	55	11	ding	ding	PROPN
admet-317	55	12	,	,	PUNCT
admet-317	55	13	c.	c.	PROPN
admet-317	55	14	lu	lu	PROPN
admet-317	55	15	,	,	PUNCT
admet-317	55	16	acta	acta	PROPN
admet-317	55	17	pharmaceutica	pharmaceutica	PROPN
admet-317	55	18	sinica	sinica	PROPN
admet-317	55	19	b	b	PROPN
admet-317	55	20	2	2	NUM
admet-317	55	21	(	(	PUNCT
admet-317	55	22	2012	2012	NUM
admet-317	55	23	)	)	PUNCT
admet-317	55	24	549	549	NUM
admet-317	55	25	-	-	SYM
admet-317	55	26	561	561	NUM
admet-317	55	27	.	.	PUNCT
admet-317	56	1	[	[	X
admet-317	56	2	5	5	NUM
admet-317	56	3	]	]	X
admet-317	56	4	a.n	a.n	PROPN
admet-317	56	5	.	.	PROPN
admet-317	56	6	shaik	shaik	PROPN
admet-317	56	7	,	,	PUNCT
admet-317	56	8	r.	r.	PROPN
admet-317	56	9	grater	grater	PROPN
admet-317	56	10	,	,	PUNCT
admet-317	56	11	m.	m.	NOUN
admet-317	56	12	lulla	lulla	PROPN
admet-317	56	13	,	,	PUNCT
admet-317	56	14	d.a	d.a	PROPN
admet-317	56	15	.	.	PROPN
admet-317	56	16	williams	williams	PROPN
admet-317	56	17	,	,	PUNCT
admet-317	56	18	l.l	l.l	PROPN
admet-317	56	19	.	.	PROPN
admet-317	56	20	gan	gan	PROPN
admet-317	56	21	,	,	PUNCT
admet-317	56	22	t.	t.	PROPN
admet-317	56	23	bohnert	bohnert	PROPN
admet-317	56	24	,	,	PUNCT
admet-317	56	25	b.w	b.w	PROPN
admet-317	56	26	.	.	PROPN
admet-317	56	27	leduc	leduc	PROPN
admet-317	56	28	,	,	PUNCT
admet-317	56	29	journal	journal	NOUN
admet-317	56	30	of	of	ADP
admet-317	56	31	chromatography	chromatography	PROPN
admet-317	56	32	b	b	PROPN
admet-317	56	33	,	,	PUNCT
admet-317	56	34	analytical	analytical	ADJ
admet-317	56	35	technologies	technology	NOUN
admet-317	56	36	in	in	ADP
admet-317	56	37	the	the	DET
admet-317	56	38	biomedical	biomedical	ADJ
admet-317	56	39	and	and	CCONJ
admet-317	56	40	life	life	NOUN
admet-317	56	41	sciences	science	NOUN
admet-317	56	42	1008	1008	NUM
admet-317	56	43	(	(	PUNCT
admet-317	56	44	2016	2016	NUM
admet-317	56	45	)	)	PUNCT
admet-317	56	46	164	164	NUM
admet-317	56	47	-	-	SYM
admet-317	56	48	173	173	NUM
admet-317	56	49	.	.	PUNCT
admet-317	57	1	[	[	X
admet-317	57	2	6	6	NUM
admet-317	57	3	]	]	X
admet-317	57	4	a.n	a.n	PROPN
admet-317	57	5	.	.	PROPN
admet-317	57	6	shaik	shaik	PROPN
admet-317	57	7	,	,	PUNCT
admet-317	57	8	m.y	m.y	PROPN
admet-317	57	9	.	.	PROPN
admet-317	57	10	mahat	mahat	PROPN
admet-317	57	11	,	,	PUNCT
admet-317	57	12	k.	k.	PROPN
admet-317	57	13	kandasamy	kandasamy	PROPN
admet-317	57	14	,	,	PUNCT
admet-317	57	15	b.w	b.w	PROPN
admet-317	57	16	.	.	PROPN
admet-317	57	17	leduc	leduc	PROPN
admet-317	57	18	,	,	PUNCT
admet-317	57	19	a.a	a.a	PROPN
admet-317	57	20	.	.	PROPN
admet-317	57	21	khan	khan	PROPN
admet-317	57	22	,	,	PUNCT
admet-317	57	23	azoles	azole	NOUN
admet-317	57	24	as	as	ADP
admet-317	57	25	novel	novel	ADJ
admet-317	57	26	inhibitors	inhibitor	NOUN
admet-317	57	27	of	of	ADP
admet-317	57	28	monoamine	monoamine	ADJ
admet-317	57	29	oxidase	oxidase	NOUN
admet-317	57	30	(	(	PUNCT
admet-317	57	31	mao	mao	PROPN
admet-317	57	32	)	)	PUNCT
admet-317	58	1	a	a	DET
admet-317	58	2	and	and	CCONJ
admet-317	58	3	b	b	NUM
admet-317	58	4	isozymes	isozyme	NOUN
admet-317	58	5	,	,	PUNCT
admet-317	58	6	drug	drug	NOUN
admet-317	58	7	metabolism	metabolism	NOUN
admet-317	58	8	reviews	review	NOUN
admet-317	58	9	,	,	PUNCT
admet-317	58	10	taylor	taylor	PROPN
admet-317	58	11	&	&	CCONJ
admet-317	58	12	francis	francis	PROPN
admet-317	58	13	ltd	ltd	PROPN
admet-317	58	14	4	4	NUM
admet-317	58	15	park	park	NOUN
admet-317	58	16	square	square	NOUN
admet-317	58	17	,	,	PUNCT
admet-317	58	18	milton	milton	PROPN
admet-317	58	19	park	park	PROPN
admet-317	58	20	,	,	PUNCT
admet-317	58	21	abingdon	abingdon	PROPN
admet-317	58	22	ox14	ox14	PROPN
admet-317	58	23	4rn	4rn	PROPN
admet-317	58	24	,	,	PUNCT
admet-317	58	25	oxon	oxon	PROPN
admet-317	58	26	,	,	PUNCT
admet-317	58	27	england	england	PROPN
admet-317	58	28	,	,	PUNCT
admet-317	58	29	2015	2015	NUM
admet-317	58	30	,	,	PUNCT
admet-317	58	31	pp	pp	ADJ
admet-317	58	32	.	.	PUNCT
admet-317	59	1	204	204	NUM
admet-317	59	2	-	-	SYM
admet-317	59	3	204	204	NUM
admet-317	59	4	.	.	PUNCT
admet-317	60	1	[	[	X
admet-317	60	2	7	7	X
admet-317	60	3	]	]	PUNCT
admet-317	60	4	b.	b.	PROPN
admet-317	60	5	wu	wu	PROPN
admet-317	60	6	,	,	PUNCT
admet-317	60	7	k.	k.	PROPN
admet-317	60	8	kulkarni	kulkarni	PROPN
admet-317	60	9	,	,	PUNCT
admet-317	60	10	s.	s.	PROPN
admet-317	60	11	basu	basu	PROPN
admet-317	60	12	,	,	PUNCT
admet-317	60	13	s.	s.	PROPN
admet-317	60	14	zhang	zhang	PROPN
admet-317	60	15	,	,	PUNCT
admet-317	60	16	m.	m.	PROPN
admet-317	60	17	hu	hu	PROPN
admet-317	60	18	,	,	PUNCT
admet-317	60	19	journal	journal	NOUN
admet-317	60	20	of	of	ADP
admet-317	60	21	pharmaceutical	pharmaceutical	PROPN
admet-317	60	22	sciences	science	NOUN
admet-317	60	23	100	100	NUM
admet-317	60	24	(	(	PUNCT
admet-317	60	25	2011	2011	NUM
admet-317	60	26	)	)	PUNCT
admet-317	60	27	36553681	36553681	NUM
admet-317	60	28	.	.	PUNCT
admet-317	61	1	[	[	X
admet-317	61	2	8	8	NUM
admet-317	61	3	]	]	PUNCT
admet-317	61	4	b.	b.	PROPN
admet-317	61	5	wu	wu	PROPN
admet-317	61	6	,	,	PUNCT
admet-317	61	7	s.	s.	PROPN
admet-317	61	8	basu	basu	PROPN
admet-317	61	9	,	,	PUNCT
admet-317	61	10	s.	s.	PROPN
admet-317	61	11	meng	meng	PROPN
admet-317	61	12	,	,	PUNCT
admet-317	61	13	x.	x.	PROPN
admet-317	61	14	wang	wang	PROPN
admet-317	61	15	,	,	PUNCT
admet-317	61	16	m.	m.	PROPN
admet-317	61	17	hu	hu	PROPN
admet-317	61	18	,	,	PUNCT
admet-317	61	19	current	current	ADJ
admet-317	61	20	drug	drug	NOUN
admet-317	61	21	metabolism	metabolism	NOUN
admet-317	61	22	12	12	NUM
admet-317	61	23	(	(	PUNCT
admet-317	61	24	2011	2011	NUM
admet-317	61	25	)	)	PUNCT
admet-317	61	26	900	900	NUM
admet-317	61	27	-	-	SYM
admet-317	61	28	916	916	NUM
admet-317	61	29	.	.	PUNCT
admet-317	62	1	[	[	X
admet-317	62	2	9	9	NUM
admet-317	62	3	]	]	X
admet-317	62	4	d.m	d.m	X
admet-317	62	5	.	.	PROPN
admet-317	62	6	cross	cross	PROPN
admet-317	62	7	,	,	PUNCT
admet-317	62	8	m.k	m.k	PROPN
admet-317	62	9	.	.	PROPN
admet-317	62	10	bayliss	bayliss	PROPN
admet-317	62	11	,	,	PUNCT
admet-317	62	12	drug	drug	NOUN
admet-317	62	13	metabolism	metabolism	NOUN
admet-317	62	14	reviews	review	NOUN
admet-317	62	15	32	32	NUM
admet-317	62	16	(	(	PUNCT
admet-317	62	17	2000	2000	NUM
admet-317	62	18	)	)	PUNCT
admet-317	62	19	219	219	NUM
admet-317	62	20	-	-	SYM
admet-317	62	21	240	240	NUM
admet-317	62	22	.	.	PUNCT
admet-317	63	1	[	[	X
admet-317	63	2	10	10	NUM
admet-317	63	3	]	]	X
admet-317	63	4	g.	g.	PROPN
admet-317	63	5	luo	luo	PROPN
admet-317	63	6	,	,	PUNCT
admet-317	63	7	m.	m.	PROPN
admet-317	63	8	cunningham	cunningham	PROPN
admet-317	63	9	,	,	PUNCT
admet-317	63	10	s.	s.	PROPN
admet-317	63	11	kim	kim	PROPN
admet-317	63	12	,	,	PUNCT
admet-317	63	13	t.	t.	PROPN
admet-317	63	14	burn	burn	NOUN
admet-317	63	15	,	,	PUNCT
admet-317	63	16	j.	j.	PROPN
admet-317	63	17	lin	lin	PROPN
admet-317	63	18	,	,	PUNCT
admet-317	63	19	m.	m.	NOUN
admet-317	63	20	sinz	sinz	PROPN
admet-317	63	21	,	,	PUNCT
admet-317	63	22	g.	g.	PROPN
admet-317	63	23	hamilton	hamilton	PROPN
admet-317	63	24	,	,	PUNCT
admet-317	63	25	c.	c.	PROPN
admet-317	63	26	rizzo	rizzo	PROPN
admet-317	63	27	,	,	PUNCT
admet-317	63	28	s.	s.	PROPN
admet-317	63	29	jolley	jolley	PROPN
admet-317	63	30	,	,	PUNCT
admet-317	63	31	d.	d.	PROPN
admet-317	63	32	gilbert	gilbert	PROPN
admet-317	63	33	,	,	PUNCT
admet-317	63	34	a.	a.	PROPN
admet-317	63	35	downey	downey	PROPN
admet-317	63	36	,	,	PUNCT
admet-317	63	37	d.	d.	PROPN
admet-317	63	38	mudra	mudra	PROPN
admet-317	63	39	,	,	PUNCT
admet-317	63	40	r.	r.	PROPN
admet-317	63	41	graham	graham	PROPN
admet-317	63	42	,	,	PUNCT
admet-317	63	43	k.	k.	PROPN
admet-317	63	44	carroll	carroll	PROPN
admet-317	63	45	,	,	PUNCT
admet-317	63	46	j.	j.	PROPN
admet-317	63	47	xie	xie	PROPN
admet-317	63	48	,	,	PUNCT
admet-317	63	49	a.	a.	PROPN
admet-317	63	50	madan	madan	PROPN
admet-317	63	51	,	,	PUNCT
admet-317	63	52	a.	a.	NOUN
admet-317	63	53	parkinson	parkinson	NOUN
admet-317	63	54	,	,	PUNCT
admet-317	63	55	d.	d.	PROPN
admet-317	63	56	christ	christ	PROPN
admet-317	63	57	,	,	PUNCT
admet-317	63	58	b.	b.	PROPN
admet-317	63	59	selling	selling	PROPN
admet-317	63	60	,	,	PUNCT
admet-317	63	61	e.	e.	PROPN
admet-317	63	62	lecluyse	lecluyse	PROPN
admet-317	63	63	,	,	PUNCT
admet-317	63	64	l.s	l.s	PROPN
admet-317	63	65	.	.	PROPN
admet-317	63	66	gan	gan	PROPN
admet-317	63	67	,	,	PUNCT
admet-317	63	68	drug	drug	NOUN
admet-317	63	69	metabolism	metabolism	NOUN
admet-317	63	70	and	and	CCONJ
admet-317	63	71	disposition	disposition	NOUN
admet-317	63	72	:	:	PUNCT
admet-317	63	73	the	the	DET
admet-317	63	74	biological	biological	ADJ
admet-317	63	75	fate	fate	NOUN
admet-317	63	76	of	of	ADP
admet-317	63	77	chemicals	chemical	NOUN
admet-317	63	78	30	30	NUM
admet-317	63	79	(	(	PUNCT
admet-317	63	80	2002	2002	NUM
admet-317	63	81	)	)	PUNCT
admet-317	63	82	795804	795804	NUM
admet-317	63	83	.	.	PUNCT
admet-317	64	1	[	[	X
admet-317	64	2	11	11	NUM
admet-317	64	3	]	]	PUNCT
admet-317	64	4	s.	s.	PROPN
admet-317	64	5	gao	gao	PROPN
admet-317	64	6	,	,	PUNCT
admet-317	64	7	s.	s.	PROPN
admet-317	64	8	basu	basu	PROPN
admet-317	64	9	,	,	PUNCT
admet-317	64	10	z.	z.	PROPN
admet-317	64	11	yang	yang	PROPN
admet-317	64	12	,	,	PUNCT
admet-317	64	13	a.	a.	PROPN
admet-317	64	14	deb	deb	PROPN
admet-317	64	15	,	,	PUNCT
admet-317	64	16	m.	m.	PROPN
admet-317	64	17	hu	hu	PROPN
admet-317	64	18	,	,	PUNCT
admet-317	64	19	current	current	ADJ
admet-317	64	20	drug	drug	NOUN
admet-317	64	21	targets	target	NOUN
admet-317	64	22	13	13	NUM
admet-317	64	23	(	(	PUNCT
admet-317	64	24	2012	2012	NUM
admet-317	64	25	)	)	PUNCT
admet-317	64	26	1885	1885	NUM
admet-317	64	27	-	-	SYM
admet-317	64	28	1899	1899	NUM
admet-317	64	29	.	.	PUNCT
admet-317	65	1	©	©	PROPN
admet-317	65	2	2016	2016	NUM
admet-317	65	3	by	by	ADP
admet-317	65	4	the	the	DET
admet-317	65	5	authors	author	NOUN
admet-317	65	6	;	;	PUNCT
admet-317	65	7	licensee	licensee	PROPN
admet-317	65	8	iapc	iapc	PROPN
admet-317	65	9	,	,	PUNCT
admet-317	65	10	zagreb	zagreb	PROPN
admet-317	65	11	,	,	PUNCT
admet-317	65	12	croatia	croatia	PROPN
admet-317	65	13	.	.	PUNCT
admet-317	66	1	this	this	DET
admet-317	66	2	article	article	NOUN
admet-317	66	3	is	be	AUX
admet-317	66	4	an	an	DET
admet-317	66	5	open	open	ADJ
admet-317	66	6	-	-	PUNCT
admet-317	66	7	access	access	NOUN
admet-317	66	8	article	article	NOUN
admet-317	66	9	distributed	distribute	VERB
admet-317	66	10	under	under	ADP
admet-317	66	11	the	the	DET
admet-317	66	12	terms	term	NOUN
admet-317	66	13	and	and	CCONJ
admet-317	66	14	conditions	condition	NOUN
admet-317	66	15	of	of	ADP
admet-317	66	16	the	the	DET
admet-317	66	17	creative	creative	ADJ
admet-317	66	18	commons	common	NOUN
admet-317	66	19	attribution	attribution	NOUN
admet-317	66	20	license	license	NOUN
admet-317	66	21	(	(	PUNCT
admet-317	66	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-317	66	23	)	)	PUNCT
admet-317	66	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN