id	sid	tid	token	lemma	pos
admet-327	1	1	manuscript	manuscript	PROPN
admet-327	1	2	doi	doi	PROPN
admet-327	1	3	:	:	PUNCT
admet-327	1	4	10.5599	10.5599	NUM
admet-327	1	5	/	/	SYM
admet-327	1	6	admet.0000.0000	admet.0000.0000	PROPN
admet-327	1	7	47	47	NUM
admet-327	1	8	admet	admet	X
admet-327	1	9	&	&	CCONJ
admet-327	1	10	dmpk	dmpk	PROPN
admet-327	1	11	5(1	5(1	NUM
admet-327	1	12	)	)	PUNCT
admet-327	1	13	(	(	PUNCT
admet-327	1	14	2017	2017	NUM
admet-327	1	15	)	)	PUNCT
admet-327	1	16	47	47	NUM
admet-327	1	17	-	-	SYM
admet-327	1	18	56	56	NUM
admet-327	1	19	;	;	PUNCT
admet-327	1	20	doi	doi	NOUN
admet-327	1	21	:	:	PUNCT
admet-327	1	22	10.5599	10.5599	NUM
admet-327	1	23	/	/	SYM
admet-327	1	24	admet.5.1.327	admet.5.1.327	NOUN
admet-327	1	25	open	open	ADJ
admet-327	1	26	access	access	NOUN
admet-327	1	27	:	:	PUNCT
admet-327	1	28	issn	issn	PROPN
admet-327	1	29	:	:	PUNCT
admet-327	1	30	1848	1848	NUM
admet-327	1	31	-	-	SYM
admet-327	1	32	7718	7718	NUM
admet-327	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-327	1	34	original	original	ADJ
admet-327	1	35	scientific	scientific	ADJ
admet-327	1	36	paper	paper	NOUN
admet-327	1	37	the	the	DET
admet-327	1	38	inhibition	inhibition	NOUN
admet-327	1	39	of	of	ADP
admet-327	1	40	adenylate	adenylate	ADJ
admet-327	1	41	kinase	kinase	NOUN
admet-327	1	42	by	by	ADP
admet-327	1	43	2,4	2,4	NUM
admet-327	1	44	-	-	PUNCT
admet-327	1	45	thiazolidinedione	thiazolidinedione	NOUN
admet-327	1	46	evaluated	evaluate	VERB
admet-327	1	47	by	by	ADP
admet-327	1	48	protein	protein	NOUN
admet-327	1	49	-	-	PUNCT
admet-327	1	50	ligand	ligand	NOUN
admet-327	1	51	docking	docking	NOUN
admet-327	1	52	mihaela	mihaela	PROPN
admet-327	1	53	ileana	ileana	PROPN
admet-327	1	54	ionescu	ionescu	PROPN
admet-327	1	55	iuliu	iuliu	PROPN
admet-327	1	56	hatieganu	hatieganu	PROPN
admet-327	1	57	university	university	PROPN
admet-327	1	58	of	of	ADP
admet-327	1	59	medicine	medicine	NOUN
admet-327	1	60	and	and	CCONJ
admet-327	1	61	pharmacy	pharmacy	NOUN
admet-327	1	62	,	,	PUNCT
admet-327	1	63	department	department	NOUN
admet-327	1	64	of	of	ADP
admet-327	1	65	microbiology	microbiology	NOUN
admet-327	1	66	,	,	PUNCT
admet-327	1	67	6	6	NUM
admet-327	1	68	pasteur	pasteur	NOUN
admet-327	1	69	,	,	PUNCT
admet-327	1	70	cluj	cluj	PROPN
admet-327	1	71	-	-	PUNCT
admet-327	1	72	napoca	napoca	NOUN
admet-327	1	73	,	,	PUNCT
admet-327	1	74	romania	romania	PROPN
admet-327	1	75	corresponding	corresponding	PROPN
admet-327	1	76	author	author	NOUN
admet-327	1	77	:	:	PUNCT
admet-327	1	78	e	e	NOUN
admet-327	1	79	-	-	NOUN
admet-327	1	80	mail	mail	NOUN
admet-327	1	81	:	:	PUNCT
admet-327	1	82	mionescu@umfcluj.ro	mionescu@umfcluj.ro	NOUN
admet-327	1	83	received	receive	VERB
admet-327	1	84	:	:	PUNCT
admet-327	1	85	july	july	PROPN
admet-327	1	86	14	14	NUM
admet-327	1	87	,	,	PUNCT
admet-327	1	88	2016	2016	NUM
admet-327	1	89	;	;	PUNCT
admet-327	1	90	revised	revise	VERB
admet-327	1	91	:	:	PUNCT
admet-327	1	92	february	february	PROPN
admet-327	1	93	16	16	NUM
admet-327	1	94	,	,	PUNCT
admet-327	1	95	2017	2017	NUM
admet-327	1	96	;	;	PUNCT
admet-327	1	97	published	publish	VERB
admet-327	1	98	:	:	PUNCT
admet-327	1	99	march	march	PROPN
admet-327	1	100	25	25	NUM
admet-327	1	101	,	,	PUNCT
admet-327	1	102	2017	2017	NUM
admet-327	1	103	abstract	abstract	ADJ
admet-327	1	104	due	due	ADP
admet-327	1	105	to	to	ADP
admet-327	1	106	its	its	PRON
admet-327	1	107	crucial	crucial	ADJ
admet-327	1	108	role	role	NOUN
admet-327	1	109	in	in	ADP
admet-327	1	110	nucleotide	nucleotide	ADJ
admet-327	1	111	metabolism	metabolism	NOUN
admet-327	1	112	,	,	PUNCT
admet-327	1	113	adenylate	adenylate	ADJ
admet-327	1	114	kinase	kinase	NOUN
admet-327	1	115	deserves	deserve	VERB
admet-327	1	116	a	a	DET
admet-327	1	117	special	special	ADJ
admet-327	1	118	attention	attention	NOUN
admet-327	1	119	in	in	ADP
admet-327	1	120	screening	screening	NOUN
admet-327	1	121	of	of	ADP
admet-327	1	122	potential	potential	ADJ
admet-327	1	123	inhibitors	inhibitor	NOUN
admet-327	1	124	.	.	PUNCT
admet-327	2	1	herein	herein	NOUN
admet-327	2	2	,	,	PUNCT
admet-327	2	3	we	we	PRON
admet-327	2	4	report	report	VERB
admet-327	2	5	the	the	DET
admet-327	2	6	assessment	assessment	NOUN
admet-327	2	7	of	of	ADP
admet-327	2	8	the	the	DET
admet-327	2	9	relative	relative	ADJ
admet-327	2	10	orientation	orientation	NOUN
admet-327	2	11	of	of	ADP
admet-327	2	12	the	the	DET
admet-327	2	13	ligand	ligand	NOUN
admet-327	2	14	2,4thiazolidinedione	2,4thiazolidinedione	NUM
admet-327	2	15	to	to	PART
admet-327	2	16	adenylate	adenylate	VERB
admet-327	2	17	kinase	kinase	NOUN
admet-327	2	18	crystallized	crystallize	VERB
admet-327	2	19	in	in	ADP
admet-327	2	20	closed	closed	ADJ
admet-327	2	21	conformation	conformation	NOUN
admet-327	2	22	.	.	PUNCT
admet-327	3	1	protein	protein	NOUN
admet-327	3	2	-	-	PUNCT
admet-327	3	3	ligand	ligand	NOUN
admet-327	3	4	docking	docking	NOUN
admet-327	3	5	was	be	AUX
admet-327	3	6	performed	perform	VERB
admet-327	3	7	to	to	PART
admet-327	3	8	estimate	estimate	VERB
admet-327	3	9	the	the	DET
admet-327	3	10	binding	bind	VERB
admet-327	3	11	energy	energy	NOUN
admet-327	3	12	and	and	CCONJ
admet-327	3	13	inhibition	inhibition	NOUN
admet-327	3	14	constant	constant	ADJ
admet-327	3	15	of	of	ADP
admet-327	3	16	2,4	2,4	NUM
admet-327	3	17	-	-	PUNCT
admet-327	3	18	thiazolidinedione	thiazolidinedione	NOUN
admet-327	3	19	to	to	ADP
admet-327	3	20	the	the	DET
admet-327	3	21	adenylate	adenylate	ADJ
admet-327	3	22	kinases	kinase	NOUN
admet-327	3	23	’	'	PUNCT
admet-327	3	24	active	active	ADJ
admet-327	3	25	sites	site	NOUN
admet-327	3	26	from	from	ADP
admet-327	3	27	different	different	ADJ
admet-327	3	28	organisms	organism	NOUN
admet-327	3	29	.	.	PUNCT
admet-327	4	1	our	our	PRON
admet-327	4	2	results	result	NOUN
admet-327	4	3	revealed	reveal	VERB
admet-327	4	4	the	the	DET
admet-327	4	5	best	good	ADJ
admet-327	4	6	orientation	orientation	NOUN
admet-327	4	7	of	of	ADP
admet-327	4	8	2,4thiazolidinedione	2,4thiazolidinedione	NUM
admet-327	4	9	is	be	AUX
admet-327	4	10	with	with	ADP
admet-327	4	11	gram	gram	NOUN
admet-327	4	12	-	-	PUNCT
admet-327	4	13	positive	positive	ADJ
admet-327	4	14	and	and	CCONJ
admet-327	4	15	acid	acid	ADJ
admet-327	4	16	fast	fast	ADJ
admet-327	4	17	bacteria	bacteria	NOUN
admet-327	4	18	adenylate	adenylate	ADJ
admet-327	4	19	kinase	kinase	NOUN
admet-327	4	20	–	–	PUNCT
admet-327	4	21	ki	ki	PROPN
admet-327	5	1	=	=	PUNCT
admet-327	5	2	0.76±0.1	0.76±0.1	PROPN
admet-327	5	3	mm	mm	NOUN
admet-327	5	4	and	and	CCONJ
admet-327	5	5	binding	bind	VERB
admet-327	5	6	energy	energy	NOUN
admet-327	5	7	-4.26±0.08	-4.26±0.08	PROPN
admet-327	5	8	kcal	kcal	PROPN
admet-327	5	9	/	/	SYM
admet-327	5	10	mol	mol	PROPN
admet-327	5	11	.	.	PUNCT
admet-327	6	1	human	human	ADJ
admet-327	6	2	adenylate	adenylate	ADJ
admet-327	6	3	kinases	kinase	NOUN
admet-327	6	4	display	display	VERB
admet-327	6	5	unfavourable	unfavourable	ADJ
admet-327	6	6	interactions	interaction	NOUN
admet-327	6	7	,	,	PUNCT
admet-327	6	8	the	the	DET
admet-327	6	9	binding	bind	VERB
admet-327	6	10	affinity	affinity	NOUN
admet-327	6	11	fluctuating	fluctuate	VERB
admet-327	6	12	among	among	ADP
admet-327	6	13	ki=0.84	ki=0.84	PROPN
admet-327	6	14	mm	mm	PROPN
admet-327	6	15	and	and	CCONJ
admet-327	6	16	8.8	8.8	NUM
admet-327	6	17	mm	mm	NOUN
admet-327	6	18	(	(	PUNCT
admet-327	6	19	3.88±3.51	3.88±3.51	NOUN
admet-327	6	20	)	)	PUNCT
admet-327	6	21	;	;	PUNCT
admet-327	6	22	the	the	DET
admet-327	6	23	energy	energy	NOUN
admet-327	6	24	binding	bind	VERB
admet-327	6	25	-3.56±0.57	-3.56±0.57	PROPN
admet-327	6	26	.	.	PUNCT
admet-327	7	1	from	from	ADP
admet-327	7	2	the	the	DET
admet-327	7	3	three	three	NUM
admet-327	7	4	human	human	ADJ
admet-327	7	5	adenylate	adenylate	ADJ
admet-327	7	6	kinases	kinase	NOUN
admet-327	7	7	analysed	analyse	VERB
admet-327	7	8	,	,	PUNCT
admet-327	7	9	only	only	ADV
admet-327	7	10	isoenzyme	isoenzyme	NOUN
admet-327	7	11	2	2	NUM
admet-327	7	12	shows	show	VERB
admet-327	7	13	a	a	DET
admet-327	7	14	binding	bind	VERB
admet-327	7	15	conformation	conformation	NOUN
admet-327	7	16	similar	similar	ADJ
admet-327	7	17	to	to	ADP
admet-327	7	18	its	its	PRON
admet-327	7	19	counterpart	counterpart	NOUN
admet-327	7	20	from	from	ADP
admet-327	7	21	e.	e.	PROPN
admet-327	7	22	coli	coli	PROPN
admet-327	7	23	.	.	PUNCT
admet-327	8	1	adenylate	adenylate	ADJ
admet-327	8	2	kinase	kinase	NOUN
admet-327	8	3	this	this	DET
admet-327	8	4	small	small	ADJ
admet-327	8	5	enzyme	enzyme	NOUN
admet-327	8	6	needed	need	VERB
admet-327	8	7	for	for	ADP
admet-327	8	8	survival	survival	NOUN
admet-327	8	9	of	of	ADP
admet-327	8	10	every	every	DET
admet-327	8	11	organisms	organism	NOUN
admet-327	8	12	interacts	interact	VERB
admet-327	8	13	differently	differently	ADV
admet-327	8	14	with	with	ADP
admet-327	8	15	2,4	2,4	NUM
admet-327	8	16	-	-	PUNCT
admet-327	8	17	thiazolidinedione	thiazolidinedione	ADJ
admet-327	8	18	,	,	PUNCT
admet-327	8	19	this	this	DET
admet-327	8	20	selectivity	selectivity	NOUN
admet-327	8	21	being	be	AUX
admet-327	8	22	the	the	DET
admet-327	8	23	most	most	ADV
admet-327	8	24	important	important	ADJ
admet-327	8	25	evidence	evidence	NOUN
admet-327	8	26	of	of	ADP
admet-327	8	27	the	the	DET
admet-327	8	28	present	present	ADJ
admet-327	8	29	study	study	NOUN
admet-327	8	30	.	.	PUNCT
admet-327	9	1	keywords	keyword	VERB
admet-327	9	2	molecular	molecular	ADJ
admet-327	9	3	docking	docking	NOUN
admet-327	9	4	;	;	PUNCT
admet-327	9	5	2	2	NUM
admet-327	9	6	,	,	PUNCT
admet-327	9	7	4	4	NUM
admet-327	9	8	-	-	PUNCT
admet-327	9	9	thiazolidinedione	thiazolidinedione	NUM
admet-327	9	10	introduction	introduction	NOUN
admet-327	9	11	bacterial	bacterial	ADJ
admet-327	9	12	resistance	resistance	NOUN
admet-327	9	13	to	to	ADP
admet-327	9	14	antibiotics	antibiotic	NOUN
admet-327	9	15	is	be	AUX
admet-327	9	16	an	an	DET
admet-327	9	17	evolving	evolve	VERB
admet-327	9	18	problem	problem	NOUN
admet-327	9	19	of	of	ADP
admet-327	9	20	medical	medical	ADJ
admet-327	9	21	practice	practice	NOUN
admet-327	9	22	[	[	X
admet-327	9	23	1,2	1,2	NUM
admet-327	9	24	]	]	PUNCT
admet-327	9	25	.	.	PUNCT
admet-327	10	1	discovery	discovery	NOUN
admet-327	10	2	of	of	ADP
admet-327	10	3	new	new	ADJ
admet-327	10	4	antibacterial	antibacterial	ADJ
admet-327	10	5	agents	agent	NOUN
admet-327	10	6	and/or	and/or	CCONJ
admet-327	10	7	reevaluating	reevaluate	VERB
admet-327	10	8	of	of	ADP
admet-327	10	9	different	different	ADJ
admet-327	10	10	targets	target	NOUN
admet-327	10	11	are	be	AUX
admet-327	10	12	impetuously	impetuously	ADV
admet-327	10	13	needed	need	VERB
admet-327	10	14	[	[	PUNCT
admet-327	10	15	3	3	NUM
admet-327	10	16	]	]	PUNCT
admet-327	10	17	,	,	PUNCT
admet-327	10	18	[	[	X
admet-327	10	19	4	4	NUM
admet-327	10	20	]	]	PUNCT
admet-327	10	21	.	.	PUNCT
admet-327	11	1	these	these	DET
admet-327	11	2	kinds	kind	NOUN
admet-327	11	3	of	of	ADP
admet-327	11	4	studies	study	NOUN
admet-327	11	5	are	be	AUX
admet-327	11	6	usually	usually	ADV
admet-327	11	7	constructed	construct	VERB
admet-327	11	8	by	by	ADP
admet-327	11	9	comparison	comparison	NOUN
admet-327	11	10	of	of	ADP
admet-327	11	11	well	well	ADV
admet-327	11	12	characterized	characterize	VERB
admet-327	11	13	pathogens	pathogen	NOUN
admet-327	11	14	.	.	PUNCT
admet-327	11	15	escherichia	escherichia	NOUN
admet-327	11	16	coli	coli	NOUN
admet-327	11	17	(	(	PUNCT
admet-327	11	18	e.	e.	NOUN
admet-327	11	19	coli	coli	PROPN
admet-327	11	20	)	)	PUNCT
admet-327	11	21	is	be	AUX
admet-327	11	22	an	an	DET
admet-327	11	23	opportunistic	opportunistic	ADJ
admet-327	11	24	gram	gram	NOUN
admet-327	11	25	-	-	PUNCT
admet-327	11	26	negative	negative	ADJ
admet-327	11	27	pathogen	pathogen	NOUN
admet-327	11	28	,	,	PUNCT
admet-327	11	29	widely	widely	ADV
admet-327	11	30	isolated	isolate	VERB
admet-327	11	31	from	from	ADP
admet-327	11	32	nosocomial	nosocomial	ADJ
admet-327	11	33	infections	infection	NOUN
admet-327	11	34	[	[	X
admet-327	11	35	5	5	NUM
admet-327	11	36	]	]	PUNCT
admet-327	11	37	.	.	PUNCT
admet-327	12	1	streptococcus	streptococcus	VERB
admet-327	12	2	pneumoniae	pneumoniae	ADJ
admet-327	12	3	(	(	PUNCT
admet-327	12	4	s.	s.	PROPN
admet-327	12	5	pneumoniae	pneumoniae	PROPN
admet-327	12	6	)	)	PUNCT
admet-327	12	7	–	–	PUNCT
admet-327	12	8	a	a	DET
admet-327	12	9	gram	gram	NOUN
admet-327	12	10	-	-	PUNCT
admet-327	12	11	positive	positive	ADJ
admet-327	12	12	cocci	cocci	NOUN
admet-327	12	13	–	–	PUNCT
admet-327	12	14	is	be	AUX
admet-327	12	15	an	an	DET
admet-327	12	16	extracellular	extracellular	ADJ
admet-327	12	17	organism	organism	NOUN
admet-327	12	18	responsible	responsible	ADJ
admet-327	12	19	for	for	ADP
admet-327	12	20	pneumoniae	pneumoniae	NOUN
admet-327	12	21	,	,	PUNCT
admet-327	12	22	otitis	otitis	NOUN
admet-327	12	23	media	medium	NOUN
admet-327	12	24	,	,	PUNCT
admet-327	12	25	meningitis	meningitis	NOUN
admet-327	12	26	and	and	CCONJ
admet-327	12	27	even	even	ADV
admet-327	12	28	sepsis	sepsis	NOUN
admet-327	12	29	in	in	ADP
admet-327	12	30	very	very	ADV
admet-327	12	31	young	young	ADJ
admet-327	12	32	children	child	NOUN
admet-327	12	33	and	and	CCONJ
admet-327	12	34	adults	adult	NOUN
admet-327	12	35	above	above	ADP
admet-327	12	36	65	65	NUM
admet-327	12	37	years	year	NOUN
admet-327	13	1	[	[	X
admet-327	13	2	6,7	6,7	NUM
admet-327	13	3	]	]	PUNCT
admet-327	13	4	.	.	PUNCT
admet-327	14	1	tuberculosis	tuberculosis	NOUN
admet-327	14	2	treatment	treatment	NOUN
admet-327	14	3	remains	remain	VERB
admet-327	14	4	one	one	NUM
admet-327	14	5	of	of	ADP
admet-327	14	6	the	the	DET
admet-327	14	7	most	most	ADV
admet-327	14	8	challenging	challenging	ADJ
admet-327	14	9	problems	problem	NOUN
admet-327	14	10	for	for	ADP
admet-327	14	11	clinicians	clinician	NOUN
admet-327	14	12	;	;	PUNCT
admet-327	14	13	multidrugresistant	multidrugresistant	ADJ
admet-327	14	14	mycobacterium	mycobacterium	NOUN
admet-327	14	15	tuberculosis	tuberculosis	NOUN
admet-327	14	16	(	(	PUNCT
admet-327	14	17	m.	m.	NOUN
admet-327	14	18	tuberculosis	tuberculosis	NOUN
admet-327	14	19	)	)	PUNCT
admet-327	14	20	strains	strain	VERB
admet-327	14	21	considerably	considerably	ADV
admet-327	14	22	diminish	diminish	VERB
admet-327	14	23	treatment	treatment	NOUN
admet-327	14	24	options	option	NOUN
admet-327	14	25	[	[	X
admet-327	14	26	8	8	NUM
admet-327	14	27	]	]	PUNCT
admet-327	14	28	.	.	PUNCT
admet-327	15	1	adenylate	adenylate	ADJ
admet-327	15	2	kinase	kinase	NOUN
admet-327	15	3	(	(	PUNCT
admet-327	15	4	ak	ak	PROPN
admet-327	15	5	)	)	PUNCT
admet-327	15	6	–	–	PUNCT
admet-327	15	7	atp	atp	PROPN
admet-327	15	8	:	:	PUNCT
admet-327	15	9	amp	amp	PROPN
admet-327	15	10	phosphotransferase	phosphotransferase	NOUN
admet-327	15	11	;	;	PUNCT
admet-327	15	12	ec	ec	PROPN
admet-327	15	13	2.7.3.4	2.7.3.4	NUM
admet-327	15	14	–	–	PUNCT
admet-327	15	15	belong	belong	VERB
admet-327	15	16	to	to	ADP
admet-327	15	17	the	the	DET
admet-327	15	18	nucleotide	nucleotide	NOUN
admet-327	15	19	kinase	kinase	PROPN
admet-327	15	20	super	super	PROPN
admet-327	15	21	family	family	NOUN
admet-327	15	22	which	which	PRON
admet-327	15	23	catalyzes	catalyze	VERB
admet-327	15	24	conversion	conversion	NOUN
admet-327	15	25	between	between	ADP
admet-327	15	26	adenylate	adenylate	ADJ
admet-327	15	27	nucleotide	nucleotide	NOUN
admet-327	15	28	by	by	ADP
admet-327	15	29	the	the	DET
admet-327	15	30	following	follow	VERB
admet-327	15	31	reaction	reaction	NOUN
admet-327	15	32	:	:	PUNCT
admet-327	15	33	mg2	mg2	PROPN
admet-327	15	34	+	+	PROPN
admet-327	15	35	atp	atp	PROPN
admet-327	15	36	+	+	CCONJ
admet-327	15	37	amp	amp	PROPN
admet-327	15	38	↔	↔	PROPN
admet-327	15	39	mg2	mg2	PROPN
admet-327	15	40	+	+	CCONJ
admet-327	15	41	adp	adp	PROPN
admet-327	15	42	+	+	PROPN
admet-327	15	43	adp	adp	PROPN
admet-327	15	44	.	.	PROPN
admet-327	15	45	ak	ak	PROPN
admet-327	15	46	is	be	AUX
admet-327	15	47	widely	widely	ADV
admet-327	15	48	studied	study	VERB
admet-327	15	49	due	due	ADP
admet-327	15	50	to	to	ADP
admet-327	15	51	its	its	PRON
admet-327	15	52	implication	implication	NOUN
admet-327	15	53	in	in	ADP
admet-327	15	54	nucleotide	nucleotide	ADJ
admet-327	15	55	metabolism	metabolism	NOUN
admet-327	15	56	and	and	CCONJ
admet-327	15	57	to	to	ADP
admet-327	15	58	its	its	PRON
admet-327	15	59	ubiquities	ubiquity	NOUN
admet-327	15	60	–	–	PUNCT
admet-327	15	61	it	it	PRON
admet-327	15	62	is	be	AUX
admet-327	15	63	described	describe	VERB
admet-327	15	64	in	in	ADP
admet-327	15	65	archaea	archaea	ADJ
admet-327	15	66	,	,	PUNCT
admet-327	15	67	prokaryotes	prokaryote	NOUN
admet-327	15	68	and	and	CCONJ
admet-327	15	69	eukaryotes	eukaryote	NOUN
admet-327	15	70	.	.	PUNCT
admet-327	16	1	some	some	DET
admet-327	16	2	aks	ak	NOUN
admet-327	16	3	are	be	AUX
admet-327	16	4	very	very	ADV
admet-327	16	5	well	well	ADV
admet-327	16	6	characterized	characterize	VERB
admet-327	16	7	,	,	PUNCT
admet-327	16	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-327	16	9	mailto:mionescu@umfcluj.ro	mailto:mionescu@umfcluj.ro	NOUN
admet-327	16	10	mihaela	mihaela	PROPN
admet-327	16	11	i.	i.	PROPN
admet-327	16	12	ionescu	ionescu	PROPN
admet-327	16	13	admet	admet	PROPN
admet-327	16	14	&	&	CCONJ
admet-327	16	15	dmpk	dmpk	PROPN
admet-327	16	16	5(1	5(1	NUM
admet-327	16	17	)	)	PUNCT
admet-327	16	18	(	(	PUNCT
admet-327	16	19	2017	2017	NUM
admet-327	16	20	)	)	PUNCT
admet-327	16	21	47	47	NUM
admet-327	16	22	-	-	SYM
admet-327	16	23	56	56	NUM
admet-327	16	24	48	48	NUM
admet-327	16	25	many	many	ADJ
admet-327	16	26	of	of	ADP
admet-327	16	27	them	they	PRON
admet-327	16	28	have	have	VERB
admet-327	16	29	the	the	DET
admet-327	16	30	crystal	crystal	NOUN
admet-327	16	31	structures	structure	NOUN
admet-327	16	32	solved	solve	VERB
admet-327	16	33	and	and	CCONJ
admet-327	16	34	biochemical	biochemical	ADJ
admet-327	16	35	parameters	parameter	NOUN
admet-327	16	36	established	establish	VERB
admet-327	16	37	.	.	PUNCT
admet-327	17	1	ak	ak	PROPN
admet-327	17	2	is	be	AUX
admet-327	17	3	a	a	DET
admet-327	17	4	flexible	flexible	ADJ
admet-327	17	5	protein	protein	NOUN
admet-327	17	6	,	,	PUNCT
admet-327	17	7	which	which	PRON
admet-327	17	8	can	can	AUX
admet-327	17	9	adopt	adopt	VERB
admet-327	17	10	different	different	ADJ
admet-327	17	11	conformations	conformation	NOUN
admet-327	17	12	during	during	ADP
admet-327	17	13	catalytic	catalytic	ADJ
admet-327	17	14	process	process	NOUN
admet-327	17	15	[	[	X
admet-327	17	16	9,10	9,10	NUM
admet-327	17	17	]	]	X
admet-327	17	18	.	.	PUNCT
admet-327	18	1	ak	ak	PROPN
admet-327	18	2	is	be	AUX
admet-327	18	3	,	,	PUNCT
admet-327	18	4	due	due	ADP
admet-327	18	5	to	to	ADP
admet-327	18	6	its	its	PRON
admet-327	18	7	universality	universality	NOUN
admet-327	18	8	and	and	CCONJ
admet-327	18	9	its	its	PRON
admet-327	18	10	flexibility	flexibility	NOUN
admet-327	18	11	,	,	PUNCT
admet-327	18	12	an	an	DET
admet-327	18	13	attractive	attractive	ADJ
admet-327	18	14	target	target	NOUN
admet-327	18	15	for	for	ADP
admet-327	18	16	screening	screening	NOUN
admet-327	18	17	of	of	ADP
admet-327	18	18	new	new	ADJ
admet-327	18	19	inhibitors	inhibitor	NOUN
admet-327	18	20	.	.	PUNCT
admet-327	19	1	thiazolidinediones	thiazolidinedione	NOUN
admet-327	19	2	(	(	PUNCT
admet-327	19	3	tzds	tzds	ADJ
admet-327	19	4	)	)	PUNCT
admet-327	19	5	derivates	derivate	NOUN
admet-327	19	6	–	–	PUNCT
admet-327	19	7	synthetic	synthetic	ADJ
admet-327	19	8	agonists	agonist	NOUN
admet-327	19	9	for	for	ADP
admet-327	19	10	the	the	DET
admet-327	19	11	peroxisome	peroxisome	PROPN
admet-327	19	12	proliferator	proliferator	PROPN
admet-327	19	13	-	-	PUNCT
admet-327	19	14	activating	activate	VERB
admet-327	19	15	receptorgamma	receptorgamma	NOUN
admet-327	19	16	receptor	receptor	NOUN
admet-327	19	17	–	–	PUNCT
admet-327	19	18	were	be	AUX
admet-327	19	19	demonstrated	demonstrate	VERB
admet-327	19	20	as	as	ADP
admet-327	19	21	potential	potential	ADJ
admet-327	19	22	inhibitors	inhibitor	NOUN
admet-327	19	23	of	of	ADP
admet-327	19	24	s.	s.	PROPN
admet-327	19	25	pneumoniae	pneumoniae	VERB
admet-327	19	26	out	out	ADJ
admet-327	19	27	-	-	PUNCT
admet-327	19	28	growth	growth	NOUN
admet-327	19	29	[	[	X
admet-327	19	30	11	11	NUM
admet-327	19	31	]	]	PUNCT
admet-327	19	32	.	.	PUNCT
admet-327	20	1	as	as	SCONJ
admet-327	20	2	we	we	PRON
admet-327	20	3	are	be	AUX
admet-327	20	4	interested	interested	ADJ
admet-327	20	5	in	in	ADP
admet-327	20	6	inhibition	inhibition	NOUN
admet-327	20	7	of	of	ADP
admet-327	20	8	ak	ak	PROPN
admet-327	20	9	by	by	ADP
admet-327	20	10	thiazolidine	thiazolidine	PROPN
admet-327	20	11	derivates	derivate	NOUN
admet-327	21	1	[	[	X
admet-327	21	2	12	12	NUM
admet-327	21	3	]	]	PUNCT
admet-327	21	4	,	,	PUNCT
admet-327	21	5	the	the	DET
admet-327	21	6	present	present	ADJ
admet-327	21	7	study	study	NOUN
admet-327	21	8	is	be	AUX
admet-327	21	9	focused	focus	VERB
admet-327	21	10	on	on	ADP
admet-327	21	11	2,4thiazolidinedione	2,4thiazolidinedione	NUM
admet-327	21	12	interaction	interaction	NOUN
admet-327	21	13	with	with	ADP
admet-327	21	14	the	the	DET
admet-327	21	15	active	active	ADJ
admet-327	21	16	site	site	NOUN
admet-327	21	17	of	of	ADP
admet-327	21	18	bacterial	bacterial	ADJ
admet-327	21	19	and	and	CCONJ
admet-327	21	20	human	human	ADJ
admet-327	21	21	aks	ak	NOUN
admet-327	21	22	.	.	PUNCT
admet-327	22	1	materials	material	NOUN
admet-327	22	2	and	and	CCONJ
admet-327	22	3	methods	method	NOUN
admet-327	22	4	data	datum	NOUN
admet-327	22	5	collection	collection	NOUN
admet-327	22	6	and	and	CCONJ
admet-327	22	7	design	design	VERB
admet-327	22	8	the	the	DET
admet-327	22	9	sequences	sequence	NOUN
admet-327	22	10	and	and	CCONJ
admet-327	22	11	annotations	annotation	NOUN
admet-327	22	12	for	for	ADP
admet-327	22	13	the	the	DET
admet-327	22	14	proteins	protein	NOUN
admet-327	22	15	examined	examine	VERB
admet-327	22	16	were	be	AUX
admet-327	22	17	collected	collect	VERB
admet-327	22	18	from	from	ADP
admet-327	22	19	ncbi	ncbi	PROPN
admet-327	22	20	protein	protein	NOUN
admet-327	22	21	database	database	NOUN
admet-327	22	22	(	(	PUNCT
admet-327	22	23	http://www.ncbi.nlm.nih.gov/protein	http://www.ncbi.nlm.nih.gov/protein	PROPN
admet-327	22	24	)	)	PUNCT
admet-327	22	25	.	.	PUNCT
admet-327	23	1	aks	aks	PROPN
admet-327	23	2	x	x	X
admet-327	23	3	-	-	NOUN
admet-327	23	4	ray	ray	ADJ
admet-327	23	5	3d	3d	PROPN
admet-327	23	6	structures	structure	NOUN
admet-327	23	7	were	be	AUX
admet-327	23	8	downloaded	download	VERB
admet-327	23	9	from	from	ADP
admet-327	23	10	the	the	DET
admet-327	23	11	protein	protein	NOUN
admet-327	23	12	data	datum	NOUN
admet-327	23	13	bank	bank	NOUN
admet-327	23	14	(	(	PUNCT
admet-327	23	15	http://www.rcsb.org/pdb	http://www.rcsb.org/pdb	PROPN
admet-327	23	16	)	)	PUNCT
admet-327	23	17	.	.	PUNCT
admet-327	24	1	aks	aks	PROPN
admet-327	24	2	co	co	VERB
admet-327	24	3	-	-	VERB
admet-327	24	4	crystallized	crystallize	VERB
admet-327	24	5	with	with	ADP
admet-327	24	6	the	the	DET
admet-327	24	7	substrates	substrate	NOUN
admet-327	24	8	or	or	CCONJ
admet-327	24	9	substrates	substrate	NOUN
admet-327	24	10	analogs	analog	NOUN
admet-327	24	11	like	like	ADP
admet-327	24	12	the	the	DET
admet-327	24	13	inhibitor	inhibitor	NOUN
admet-327	24	14	p1,p5	p1,p5	PROPN
admet-327	24	15	-	-	PUNCT
admet-327	24	16	di(adenosine-5')pentaphosphate	di(adenosine-5')pentaphosphate	NOUN
admet-327	24	17	(	(	PUNCT
admet-327	24	18	ap5a	ap5a	PROPN
admet-327	24	19	)	)	PUNCT
admet-327	24	20	(	(	PUNCT
admet-327	24	21	c20h29n10o22p5	c20h29n10o22p5	NOUN
admet-327	24	22	)	)	PUNCT
admet-327	24	23	,	,	PUNCT
admet-327	24	24	were	be	AUX
admet-327	24	25	stored	store	VERB
admet-327	24	26	for	for	ADP
admet-327	24	27	further	further	ADJ
admet-327	24	28	procedures	procedure	NOUN
admet-327	24	29	.	.	PUNCT
admet-327	25	1	the	the	DET
admet-327	25	2	structure	structure	NOUN
admet-327	25	3	of	of	ADP
admet-327	25	4	the	the	DET
admet-327	25	5	ligand	ligand	ADJ
admet-327	25	6	2,4	2,4	NUM
admet-327	25	7	-	-	PUNCT
admet-327	25	8	thiazolidinedione	thiazolidinedione	ADJ
admet-327	25	9	(	(	PUNCT
admet-327	25	10	c3h3no2s	c3h3no2s	PROPN
admet-327	25	11	)	)	PUNCT
admet-327	25	12	was	be	AUX
admet-327	25	13	retrieved	retrieve	VERB
admet-327	25	14	from	from	ADP
admet-327	25	15	the	the	DET
admet-327	25	16	open	open	ADJ
admet-327	25	17	chemistry	chemistry	NOUN
admet-327	25	18	database	database	NOUN
admet-327	25	19	–	–	PUNCT
admet-327	25	20	national	national	ADJ
admet-327	25	21	center	center	NOUN
admet-327	25	22	for	for	ADP
admet-327	25	23	biotechnology	biotechnology	NOUN
admet-327	25	24	information	information	NOUN
admet-327	25	25	pubchem	pubchem	NOUN
admet-327	25	26	compound	compound	NOUN
admet-327	25	27	database	database	NOUN
admet-327	25	28	;	;	PUNCT
admet-327	25	29	cid=5437	cid=5437	NUM
admet-327	25	30	,	,	PUNCT
admet-327	25	31	https://pubchem.ncbi.nlm.nih.gov/compound/5437	https://pubchem.ncbi.nlm.nih.gov/compound/5437	PROPN
admet-327	25	32	.	.	PUNCT
admet-327	26	1	this	this	DET
admet-327	26	2	open	open	ADJ
admet-327	26	3	database	database	NOUN
admet-327	26	4	provided	provide	VERB
admet-327	26	5	chemicals	chemical	NOUN
admet-327	26	6	as	as	ADP
admet-327	26	7	sdf	sdf	NOUN
admet-327	26	8	files	file	NOUN
admet-327	26	9	.	.	PUNCT
admet-327	27	1	protein	protein	NOUN
admet-327	27	2	-	-	PUNCT
admet-327	27	3	ligand	ligand	NOUN
admet-327	27	4	docking	docking	NOUN
admet-327	27	5	to	to	PART
admet-327	27	6	analyze	analyze	VERB
admet-327	27	7	the	the	DET
admet-327	27	8	binding	binding	NOUN
admet-327	27	9	of	of	ADP
admet-327	27	10	2,4	2,4	NUM
admet-327	27	11	-	-	PUNCT
admet-327	27	12	thiazolidinedione	thiazolidinedione	NOUN
admet-327	27	13	,	,	PUNCT
admet-327	27	14	we	we	PRON
admet-327	27	15	performed	perform	VERB
admet-327	27	16	protein	protein	NOUN
admet-327	27	17	-	-	PUNCT
admet-327	27	18	ligand	ligand	NOUN
admet-327	27	19	docking	docking	NOUN
admet-327	27	20	by	by	ADP
admet-327	27	21	autodock4	autodock4	PROPN
admet-327	27	22	,	,	PUNCT
admet-327	27	23	a	a	DET
admet-327	27	24	widely	widely	ADV
admet-327	27	25	used	use	VERB
admet-327	27	26	non	non	ADJ
admet-327	27	27	-	-	ADJ
admet-327	27	28	commercial	commercial	ADJ
admet-327	27	29	program	program	NOUN
admet-327	27	30	,	,	PUNCT
admet-327	27	31	which	which	PRON
admet-327	27	32	provided	provide	VERB
admet-327	27	33	useful	useful	ADJ
admet-327	27	34	instruments	instrument	NOUN
admet-327	27	35	for	for	ADP
admet-327	27	36	accurate	accurate	ADJ
admet-327	27	37	prediction	prediction	NOUN
admet-327	27	38	of	of	ADP
admet-327	27	39	binding	bind	VERB
admet-327	27	40	interaction	interaction	NOUN
admet-327	27	41	[	[	X
admet-327	27	42	13–15	13–15	NUM
admet-327	27	43	]	]	PUNCT
admet-327	27	44	.	.	PUNCT
admet-327	28	1	the	the	DET
admet-327	28	2	autodocktools	autodocktools	PROPN
admet-327	28	3	(	(	PUNCT
admet-327	28	4	http://mgltools.scripps.edu/downloads	http://mgltools.scripps.edu/download	NOUN
admet-327	28	5	)	)	PUNCT
admet-327	28	6	offer	offer	VERB
admet-327	28	7	an	an	DET
admet-327	28	8	excellent	excellent	ADJ
admet-327	28	9	interface	interface	NOUN
admet-327	28	10	for	for	ADP
admet-327	28	11	non	non	NOUN
admet-327	28	12	-	-	NOUN
admet-327	28	13	bioinformaticians	bioinformatician	NOUN
admet-327	28	14	.	.	PUNCT
admet-327	29	1	interpreting	interpret	VERB
admet-327	29	2	the	the	DET
admet-327	29	3	docking	docking	NOUN
admet-327	29	4	data	datum	NOUN
admet-327	29	5	was	be	AUX
admet-327	29	6	possible	possible	ADJ
admet-327	29	7	by	by	ADP
admet-327	29	8	employing	employ	VERB
admet-327	29	9	of	of	ADP
admet-327	29	10	free	free	ADJ
admet-327	29	11	3d	3d	NUM
admet-327	29	12	molecular	molecular	ADJ
admet-327	29	13	visualization	visualization	NOUN
admet-327	29	14	tools	tool	NOUN
admet-327	29	15	–	–	PUNCT
admet-327	29	16	biovia	biovia	NOUN
admet-327	29	17	discovery	discovery	PROPN
admet-327	29	18	studio	studio	PROPN
admet-327	29	19	visualizer	visualizer	PROPN
admet-327	29	20	2016	2016	NUM
admet-327	29	21	(	(	PUNCT
admet-327	29	22	ds	ds	ADJ
admet-327	29	23	visualizer	visualizer	NOUN
admet-327	29	24	2016	2016	NUM
admet-327	29	25	)	)	PUNCT
admet-327	29	26	;	;	PUNCT
admet-327	29	27	(	(	PUNCT
admet-327	29	28	http://accelrys.com/products/discovery-studio/visualization-download.php	http://accelrys.com/products/discovery-studio/visualization-download.php	NOUN
admet-327	29	29	)	)	PUNCT
admet-327	29	30	.	.	PUNCT
admet-327	30	1	aks	ak	NOUN
admet-327	30	2	included	include	VERB
admet-327	30	3	in	in	ADP
admet-327	30	4	the	the	DET
admet-327	30	5	present	present	ADJ
admet-327	30	6	study	study	NOUN
admet-327	30	7	were	be	AUX
admet-327	30	8	presented	present	VERB
admet-327	30	9	in	in	ADP
admet-327	30	10	the	the	DET
admet-327	30	11	table	table	NOUN
admet-327	30	12	1	1	NUM
admet-327	30	13	.	.	PUNCT
admet-327	31	1	firstly	firstly	ADV
admet-327	31	2	,	,	PUNCT
admet-327	31	3	from	from	ADP
admet-327	31	4	the	the	DET
admet-327	31	5	3d	3d	NUM
admet-327	31	6	structure	structure	NOUN
admet-327	31	7	,	,	PUNCT
admet-327	31	8	substrate	substrate	NOUN
admet-327	31	9	or	or	CCONJ
admet-327	31	10	substrate	substrate	NOUN
admet-327	31	11	analogs	analog	NOUN
admet-327	31	12	(	(	PUNCT
admet-327	31	13	ap5a	ap5a	PROPN
admet-327	31	14	)	)	PUNCT
admet-327	31	15	and	and	CCONJ
admet-327	31	16	all	all	DET
admet-327	31	17	solvent	solvent	ADJ
admet-327	31	18	molecules	molecule	NOUN
admet-327	31	19	were	be	AUX
admet-327	31	20	removed	remove	VERB
admet-327	31	21	and	and	CCONJ
admet-327	31	22	a	a	DET
admet-327	31	23	closed	closed	ADJ
admet-327	31	24	conformation	conformation	NOUN
admet-327	31	25	was	be	AUX
admet-327	31	26	obtained	obtain	VERB
admet-327	31	27	,	,	PUNCT
admet-327	31	28	which	which	PRON
admet-327	31	29	allows	allow	VERB
admet-327	31	30	an	an	DET
admet-327	31	31	algorithm	algorithm	NOUN
admet-327	31	32	based	base	VERB
admet-327	31	33	on	on	ADP
admet-327	31	34	a	a	DET
admet-327	31	35	rigid	rigid	ADJ
admet-327	31	36	protein	protein	NOUN
admet-327	31	37	structure	structure	NOUN
admet-327	31	38	.	.	PUNCT
admet-327	32	1	in	in	ADP
admet-327	32	2	our	our	PRON
admet-327	32	3	case	case	NOUN
admet-327	32	4	,	,	PUNCT
admet-327	32	5	this	this	DET
admet-327	32	6	docking	docking	NOUN
admet-327	32	7	algorithm	algorithm	NOUN
admet-327	32	8	was	be	AUX
admet-327	32	9	sufficient	sufficient	ADJ
admet-327	32	10	to	to	PART
admet-327	32	11	obtain	obtain	VERB
admet-327	32	12	reliable	reliable	ADJ
admet-327	32	13	data	datum	NOUN
admet-327	32	14	.	.	PUNCT
admet-327	33	1	the	the	DET
admet-327	33	2	lamarckian	lamarckian	ADJ
admet-327	33	3	genetic	genetic	ADJ
admet-327	33	4	algorithm	algorithm	NOUN
admet-327	33	5	(	(	PUNCT
admet-327	33	6	lga	lga	NOUN
admet-327	33	7	)	)	PUNCT
admet-327	33	8	,	,	PUNCT
admet-327	33	9	with	with	ADP
admet-327	33	10	a	a	DET
admet-327	33	11	maximum	maximum	NOUN
admet-327	33	12	of	of	ADP
admet-327	33	13	2,500,000	2,500,000	NUM
admet-327	33	14	energy	energy	NOUN
admet-327	33	15	evaluations	evaluation	NOUN
admet-327	33	16	,	,	PUNCT
admet-327	33	17	was	be	AUX
admet-327	33	18	choose	choose	VERB
admet-327	33	19	as	as	ADP
admet-327	33	20	searching	search	VERB
admet-327	33	21	parameter	parameter	NOUN
admet-327	34	1	[	[	X
admet-327	34	2	16	16	NUM
admet-327	34	3	]	]	PUNCT
admet-327	34	4	.	.	PUNCT
admet-327	35	1	multiple	multiple	ADJ
admet-327	35	2	sequence	sequence	NOUN
admet-327	35	3	alignment	alignment	NOUN
admet-327	35	4	multiple	multiple	ADJ
admet-327	35	5	sequence	sequence	NOUN
admet-327	35	6	alignment	alignment	NOUN
admet-327	35	7	was	be	AUX
admet-327	35	8	performed	perform	VERB
admet-327	35	9	using	use	VERB
admet-327	35	10	clustal	clustal	ADJ
admet-327	35	11	omega	omega	NOUN
admet-327	35	12	program	program	NOUN
admet-327	35	13	(	(	PUNCT
admet-327	35	14	http://www.ebi.ac.uk/tools/msa/clustalo	http://www.ebi.ac.uk/tools/msa/clustalo	NOUN
admet-327	35	15	)	)	PUNCT
admet-327	35	16	,	,	PUNCT
admet-327	35	17	an	an	DET
admet-327	35	18	open	open	ADJ
admet-327	35	19	access	access	NOUN
admet-327	35	20	tool	tool	NOUN
admet-327	35	21	provided	provide	VERB
admet-327	35	22	by	by	ADP
admet-327	35	23	the	the	DET
admet-327	35	24	european	european	PROPN
admet-327	35	25	bioinformatics	bioinformatics	PROPN
admet-327	35	26	institute	institute	PROPN
admet-327	35	27	–	–	PUNCT
admet-327	35	28	embl	embl	NOUN
admet-327	35	29	-	-	PUNCT
admet-327	35	30	ebi	ebi	NOUN
admet-327	36	1	[	[	X
admet-327	36	2	21,22	21,22	NOUN
admet-327	36	3	]	]	X
admet-327	36	4	.	.	PUNCT
admet-327	37	1	statistical	statistical	ADJ
admet-327	37	2	evaluations	evaluation	NOUN
admet-327	37	3	:	:	PUNCT
admet-327	37	4	data	datum	NOUN
admet-327	37	5	were	be	AUX
admet-327	37	6	expressed	express	VERB
admet-327	37	7	as	as	ADP
admet-327	37	8	mean	mean	NOUN
admet-327	37	9	±	±	NUM
admet-327	37	10	sd	sd	NOUN
admet-327	37	11	.	.	PUNCT
admet-327	38	1	inclusion	inclusion	NOUN
admet-327	38	2	criteria	criterion	NOUN
admet-327	38	3	:	:	PUNCT
admet-327	38	4	aks	ak	NOUN
admet-327	38	5	from	from	ADP
admet-327	38	6	any	any	DET
admet-327	38	7	microorganism	microorganism	NOUN
admet-327	38	8	or	or	CCONJ
admet-327	38	9	from	from	ADP
admet-327	38	10	human	human	ADJ
admet-327	38	11	origin	origin	NOUN
admet-327	38	12	with	with	ADP
admet-327	38	13	crystal	crystal	NOUN
admet-327	38	14	structure	structure	NOUN
admet-327	38	15	determined	determine	VERB
admet-327	38	16	by	by	ADP
admet-327	38	17	x	x	NOUN
admet-327	38	18	-	-	NOUN
admet-327	38	19	ray	ray	NOUN
admet-327	38	20	crystallography	crystallography	NOUN
admet-327	38	21	co	co	VERB
admet-327	38	22	-	-	VERB
admet-327	38	23	crystallized	crystallize	VERB
admet-327	38	24	with	with	ADP
admet-327	38	25	substrate	substrate	NOUN
admet-327	38	26	or	or	CCONJ
admet-327	38	27	substrate	substrate	NOUN
admet-327	38	28	analogs	analog	NOUN
admet-327	38	29	,	,	PUNCT
admet-327	38	30	so	so	SCONJ
admet-327	38	31	a	a	DET
admet-327	38	32	closed	closed	ADJ
admet-327	38	33	conformation	conformation	NOUN
admet-327	38	34	is	be	AUX
admet-327	38	35	provided	provide	VERB
admet-327	38	36	.	.	PUNCT
admet-327	39	1	exclusion	exclusion	NOUN
admet-327	39	2	criteria	criterion	NOUN
admet-327	39	3	:	:	PUNCT
admet-327	39	4	aks	ak	NOUN
admet-327	39	5	with	with	ADP
admet-327	39	6	no	no	DET
admet-327	39	7	crystal	crystal	NOUN
admet-327	39	8	structure	structure	NOUN
admet-327	39	9	recorded	record	VERB
admet-327	39	10	in	in	ADP
admet-327	39	11	protein	protein	NOUN
admet-327	39	12	databases	database	NOUN
admet-327	39	13	or	or	CCONJ
admet-327	39	14	3d	3d	NUM
admet-327	39	15	structure	structure	NOUN
admet-327	39	16	in	in	ADP
admet-327	39	17	open	open	ADJ
admet-327	39	18	conformation	conformation	NOUN
admet-327	39	19	.	.	PUNCT
admet-327	40	1	http://www.ncbi.nlm.nih.gov/protein	http://www.ncbi.nlm.nih.gov/protein	ADV
admet-327	40	2	http://www.rcsb.org/pdb	http://www.rcsb.org/pdb	PROPN
admet-327	40	3	http://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=c3h3no2s&sort=mw&sort_dir=asc	http://pubchem.ncbi.nlm.nih.gov/search/#collection=compounds&query_type=mf&query=c3h3no2s&sort=mw&sort_dir=asc	PUNCT
admet-327	41	1	https://pubchem.ncbi.nlm.nih.gov/compound/5437	https://pubchem.ncbi.nlm.nih.gov/compound/5437	PROPN
admet-327	41	2	http://mgltools.scripps.edu/downloads	http://mgltools.scripps.edu/download	VERB
admet-327	41	3	http://accelrys.com/products/discovery-studio/visualization-download.php	http://accelrys.com/products/discovery-studio/visualization-download.php	VERB
admet-327	41	4	http://www.ebi.ac.uk/tools/msa/clustalo	http://www.ebi.ac.uk/tools/msa/clustalo	NOUN
admet-327	41	5	admet	admet	X
admet-327	41	6	&	&	CCONJ
admet-327	41	7	dmpk	dmpk	PROPN
admet-327	41	8	5(1	5(1	NUM
admet-327	41	9	)	)	PUNCT
admet-327	41	10	(	(	PUNCT
admet-327	41	11	2017	2017	NUM
admet-327	41	12	)	)	PUNCT
admet-327	41	13	47	47	NUM
admet-327	41	14	-	-	SYM
admet-327	41	15	56	56	NUM
admet-327	41	16	adenylate	adenylate	ADJ
admet-327	41	17	kinase	kinase	NOUN
admet-327	41	18	inhibition	inhibition	NOUN
admet-327	41	19	by	by	ADP
admet-327	41	20	2,4	2,4	NUM
admet-327	41	21	-	-	PUNCT
admet-327	41	22	thiazolidinedione	thiazolidinedione	ADJ
admet-327	41	23	doi	doi	NOUN
admet-327	41	24	:	:	PUNCT
admet-327	41	25	10.5599	10.5599	NUM
admet-327	41	26	/	/	SYM
admet-327	41	27	admet.5.1.327	admet.5.1.327	PROPN
admet-327	41	28	49	49	NUM
admet-327	41	29	table	table	NOUN
admet-327	41	30	1	1	NUM
admet-327	41	31	the	the	DET
admet-327	41	32	main	main	ADJ
admet-327	41	33	characteristics	characteristic	NOUN
admet-327	41	34	of	of	ADP
admet-327	41	35	the	the	DET
admet-327	41	36	aks	ak	NOUN
admet-327	41	37	used	use	VERB
admet-327	41	38	in	in	ADP
admet-327	41	39	protein	protein	NOUN
admet-327	41	40	-	-	PUNCT
admet-327	41	41	ligand	ligand	NOUN
admet-327	41	42	docking	docking	NOUN
admet-327	41	43	accession	accession	NOUN
admet-327	41	44	number	number	NOUN
admet-327	41	45	source	source	NOUN
admet-327	41	46	co	co	NOUN
admet-327	41	47	-	-	VERB
admet-327	41	48	crystallized	crystallize	VERB
admet-327	41	49	with	with	ADP
admet-327	41	50	substrate	substrate	NOUN
admet-327	41	51	or	or	CCONJ
admet-327	41	52	substrate	substrate	NOUN
admet-327	41	53	analogs	analog	NOUN
admet-327	41	54	no	no	NOUN
admet-327	41	55	.	.	NOUN
admet-327	41	56	of	of	ADP
admet-327	41	57	residues	residue	NOUN
admet-327	41	58	references	reference	NOUN
admet-327	41	59	bacterial	bacterial	ADJ
admet-327	41	60	source	source	NOUN
admet-327	41	61	3hpq	3hpq	PROPN
admet-327	41	62	e.	e.	PROPN
admet-327	41	63	coli	coli	NOUN
admet-327	41	64	ap5a	ap5a	PROPN
admet-327	41	65	214	214	NUM
admet-327	42	1	[	[	X
admet-327	42	2	17	17	NUM
admet-327	42	3	]	]	X
admet-327	42	4	1ank	1ank	NUM
admet-327	42	5	e.	e.	PROPN
admet-327	42	6	coli	coli	PROPN
admet-327	42	7	amp	amp	PROPN
admet-327	42	8	,	,	PUNCT
admet-327	42	9	amppnp	amppnp	VERB
admet-327	42	10	214	214	NUM
admet-327	42	11	[	[	X
admet-327	42	12	18	18	NUM
admet-327	42	13	]	]	SYM
admet-327	42	14	4w5j	4w5j	NOUN
admet-327	42	15	s.	s.	PROPN
admet-327	42	16	pneumoniae	pneumoniae	ADP
admet-327	42	17	ap5a	ap5a	PROPN
admet-327	42	18	,	,	PUNCT
admet-327	42	19	mg	mg	PROPN
admet-327	42	20	2	2	NUM
admet-327	42	21	+	+	NUM
admet-327	42	22	217	217	NUM
admet-327	43	1	[	[	X
admet-327	43	2	19	19	NUM
admet-327	43	3	]	]	SYM
admet-327	43	4	1zip	1zip	PROPN
admet-327	43	5	b.	b.	PROPN
admet-327	43	6	stearothermophilus	stearothermophilus	PROPN
admet-327	43	7	ap5a	ap5a	PROPN
admet-327	43	8	,	,	PUNCT
admet-327	43	9	mn	mn	PROPN
admet-327	43	10	2	2	NUM
admet-327	43	11	+	+	CCONJ
admet-327	43	12	,	,	PUNCT
admet-327	43	13	and	and	CCONJ
admet-327	43	14	mg	mg	PROPN
admet-327	43	15	2	2	NUM
admet-327	43	16	+	+	NUM
admet-327	43	17	217	217	NUM
admet-327	44	1	[	[	X
admet-327	44	2	9	9	NUM
admet-327	44	3	]	]	SYM
admet-327	44	4	2cdn	2cdn	NUM
admet-327	44	5	m.	m.	NOUN
admet-327	44	6	tuberculosis	tuberculosis	NOUN
admet-327	44	7	two	two	NUM
admet-327	44	8	adp	adp	PROPN
admet-327	44	9	molecules	molecule	NOUN
admet-327	44	10	and	and	CCONJ
admet-327	44	11	mg	mg	PROPN
admet-327	44	12	2	2	NUM
admet-327	44	13	+	+	NUM
admet-327	44	14	201	201	NUM
admet-327	44	15	[	[	SYM
admet-327	44	16	20	20	NUM
admet-327	44	17	]	]	X
admet-327	44	18	2rgx	2rgx	PROPN
admet-327	44	19	aquifex	aquifex	PROPN
admet-327	44	20	aeolicus	aeolicus	PROPN
admet-327	44	21	ap5a	ap5a	PROPN
admet-327	44	22	,	,	PUNCT
admet-327	44	23	zn	zn	PROPN
admet-327	44	24	2	2	NUM
admet-327	44	25	+	+	NUM
admet-327	44	26	206	206	NUM
admet-327	44	27	[	[	SYM
admet-327	44	28	10	10	NUM
admet-327	44	29	]	]	PUNCT
admet-327	44	30	homo	homo	NOUN
admet-327	44	31	sapiens	sapien	VERB
admet-327	44	32	2c95	2c95	NOUN
admet-327	44	33	(	(	PUNCT
admet-327	44	34	chain	chain	VERB
admet-327	44	35	a	a	DET
admet-327	44	36	–	–	PUNCT
admet-327	44	37	ak1	ak1	NOUN
admet-327	44	38	)	)	PUNCT
admet-327	44	39	bis(adenosine)-5'-tetraphosphate	bis(adenosine)-5'-tetraphosphate	NUM
admet-327	44	40	;	;	PUNCT
admet-327	44	41	malonate	malonate	VERB
admet-327	44	42	ion	ion	NOUN
admet-327	44	43	196	196	NUM
admet-327	44	44	unpublished	unpublished	ADJ
admet-327	44	45	2c9y	2c9y	NOUN
admet-327	44	46	(	(	PUNCT
admet-327	44	47	chain	chain	NOUN
admet-327	44	48	a	a	DET
admet-327	44	49	–	–	PUNCT
admet-327	44	50	ak2	ak2	NOUN
admet-327	44	51	)	)	PUNCT
admet-327	44	52	bis(adenosine)-5'tetraphosphate	bis(adenosine)-5'tetraphosphate	NOUN
admet-327	44	53	;	;	PUNCT
admet-327	44	54	ethylene	ethylene	NOUN
admet-327	44	55	glycol	glycol	NOUN
admet-327	44	56	242	242	NUM
admet-327	44	57	unpublished	unpublished	ADJ
admet-327	44	58	2bwj	2bwj	NOUN
admet-327	44	59	(	(	PUNCT
admet-327	44	60	chain	chain	NOUN
admet-327	44	61	a	a	DET
admet-327	44	62	–	–	PUNCT
admet-327	44	63	ak5	ak5	NOUN
admet-327	44	64	)	)	PUNCT
admet-327	44	65	amp	amp	PROPN
admet-327	44	66	,	,	PUNCT
admet-327	44	67	cl	cl	INTJ
admet-327	44	68	,	,	PUNCT
admet-327	44	69	so4	so4	PROPN
admet-327	44	70	2	2	NUM
admet-327	44	71	199	199	NUM
admet-327	44	72	unpublished	unpublished	ADJ
admet-327	44	73	results	result	NOUN
admet-327	44	74	and	and	CCONJ
admet-327	44	75	discussion	discussion	NOUN
admet-327	44	76	protein	protein	NOUN
admet-327	44	77	-	-	PUNCT
admet-327	44	78	ligand	ligand	NOUN
admet-327	44	79	docking	docking	NOUN
admet-327	44	80	aks	ak	NOUN
admet-327	44	81	from	from	ADP
admet-327	44	82	different	different	ADJ
admet-327	44	83	sources	source	NOUN
admet-327	44	84	were	be	AUX
admet-327	44	85	subjected	subject	VERB
admet-327	44	86	to	to	ADP
admet-327	44	87	docking	dock	VERB
admet-327	44	88	with	with	ADP
admet-327	44	89	2,4	2,4	NUM
admet-327	44	90	-	-	PUNCT
admet-327	44	91	thiazolidinedione	thiazolidinedione	NOUN
admet-327	44	92	.	.	PUNCT
admet-327	45	1	it	it	PRON
admet-327	45	2	is	be	AUX
admet-327	45	3	already	already	ADV
admet-327	45	4	established	establish	VERB
admet-327	45	5	that	that	SCONJ
admet-327	45	6	ak	ak	PROPN
admet-327	45	7	is	be	AUX
admet-327	45	8	a	a	DET
admet-327	45	9	natural	natural	ADJ
admet-327	45	10	flexible	flexible	ADJ
admet-327	45	11	protein	protein	NOUN
admet-327	45	12	,	,	PUNCT
admet-327	45	13	binding	bind	VERB
admet-327	45	14	and	and	CCONJ
admet-327	45	15	releasing	releasing	NOUN
admet-327	45	16	of	of	ADP
admet-327	45	17	its	its	PRON
admet-327	45	18	substrates	substrate	NOUN
admet-327	45	19	are	be	AUX
admet-327	45	20	followed	follow	VERB
admet-327	45	21	by	by	ADP
admet-327	45	22	motions	motion	NOUN
admet-327	45	23	of	of	ADP
admet-327	45	24	the	the	DET
admet-327	45	25	amp	amp	NOUN
admet-327	45	26	-	-	PUNCT
admet-327	45	27	binding	bind	VERB
admet-327	45	28	domain	domain	NOUN
admet-327	45	29	and	and	CCONJ
admet-327	45	30	lid	lid	NOUN
admet-327	45	31	domain	domain	NOUN
admet-327	45	32	.	.	PUNCT
admet-327	46	1	as	as	ADP
admet-327	46	2	a	a	DET
admet-327	46	3	result	result	NOUN
admet-327	46	4	of	of	ADP
admet-327	46	5	sophisticated	sophisticated	ADJ
admet-327	46	6	conformational	conformational	ADJ
admet-327	46	7	transitions	transition	NOUN
admet-327	46	8	a	a	DET
admet-327	46	9	so	so	ADV
admet-327	46	10	-	-	PUNCT
admet-327	46	11	called	call	VERB
admet-327	46	12	closed	closed	ADJ
admet-327	46	13	conformation	conformation	NOUN
admet-327	46	14	results	result	NOUN
admet-327	46	15	during	during	ADP
admet-327	46	16	catalytic	catalytic	ADJ
admet-327	46	17	process	process	NOUN
admet-327	46	18	[	[	X
admet-327	46	19	23,24	23,24	ADP
admet-327	46	20	]	]	PUNCT
admet-327	46	21	.	.	PUNCT
admet-327	47	1	starting	start	VERB
admet-327	47	2	from	from	ADP
admet-327	47	3	these	these	DET
admet-327	47	4	premises	premise	NOUN
admet-327	47	5	,	,	PUNCT
admet-327	47	6	rigid	rigid	ADJ
admet-327	47	7	protein	protein	NOUN
admet-327	47	8	structures	structure	NOUN
admet-327	47	9	were	be	AUX
admet-327	47	10	considered	consider	VERB
admet-327	47	11	for	for	ADP
admet-327	47	12	further	further	ADJ
admet-327	47	13	docking	docking	NOUN
admet-327	47	14	algorithm	algorithm	NOUN
admet-327	47	15	.	.	PUNCT
admet-327	48	1	for	for	ADP
admet-327	48	2	each	each	DET
admet-327	48	3	ak	ak	PROPN
admet-327	48	4	,	,	PUNCT
admet-327	48	5	ten	ten	NUM
admet-327	48	6	conformations	conformation	NOUN
admet-327	48	7	were	be	AUX
admet-327	48	8	obtained	obtain	VERB
admet-327	48	9	as	as	ADP
admet-327	48	10	a	a	DET
admet-327	48	11	result	result	NOUN
admet-327	48	12	of	of	ADP
admet-327	48	13	docking	docking	NOUN
admet-327	48	14	process	process	NOUN
admet-327	48	15	.	.	PUNCT
admet-327	49	1	the	the	DET
admet-327	49	2	conformation	conformation	NOUN
admet-327	49	3	with	with	ADP
admet-327	49	4	the	the	DET
admet-327	49	5	smallest	small	ADJ
admet-327	49	6	binding	bind	VERB
admet-327	49	7	energy	energy	NOUN
admet-327	49	8	(	(	PUNCT
admet-327	49	9	∆g	∆g	PROPN
admet-327	49	10	)	)	PUNCT
admet-327	49	11	and	and	CCONJ
admet-327	49	12	the	the	DET
admet-327	49	13	smallest	small	ADJ
admet-327	49	14	inhibition	inhibition	NOUN
admet-327	49	15	constant	constant	ADJ
admet-327	49	16	(	(	PUNCT
admet-327	49	17	ki	ki	INTJ
admet-327	49	18	)	)	PUNCT
admet-327	49	19	was	be	AUX
admet-327	49	20	considered	consider	VERB
admet-327	49	21	the	the	DET
admet-327	49	22	best	good	ADJ
admet-327	49	23	.	.	PUNCT
admet-327	50	1	as	as	SCONJ
admet-327	50	2	it	it	PRON
admet-327	50	3	is	be	AUX
admet-327	50	4	shown	show	VERB
admet-327	50	5	in	in	ADP
admet-327	50	6	the	the	DET
admet-327	50	7	table	table	NOUN
admet-327	50	8	2	2	NUM
admet-327	50	9	,	,	PUNCT
admet-327	50	10	regarding	regard	VERB
admet-327	50	11	aks	ak	NOUN
admet-327	50	12	from	from	ADP
admet-327	50	13	gram	gram	NOUN
admet-327	50	14	-	-	PUNCT
admet-327	50	15	positive	positive	ADJ
admet-327	50	16	and	and	CCONJ
admet-327	50	17	acid	acid	ADJ
admet-327	50	18	fast	fast	ADJ
admet-327	50	19	species	specie	NOUN
admet-327	50	20	,	,	PUNCT
admet-327	50	21	∆g	∆g	PROPN
admet-327	50	22	values	value	NOUN
admet-327	50	23	are	be	AUX
admet-327	50	24	almost	almost	ADV
admet-327	50	25	the	the	DET
admet-327	50	26	same	same	ADJ
admet-327	50	27	with	with	ADP
admet-327	50	28	a	a	DET
admet-327	50	29	mean	mean	NOUN
admet-327	50	30	of	of	ADP
admet-327	50	31	-4.26±0.08	-4.26±0.08	PROPN
admet-327	50	32	kcal	kcal	PROPN
admet-327	50	33	/	/	SYM
admet-327	50	34	mol	mol	PROPN
admet-327	50	35	,	,	PUNCT
admet-327	50	36	and	and	CCONJ
admet-327	50	37	ki	ki	PROPN
admet-327	50	38	are	be	AUX
admet-327	50	39	clustered	cluster	VERB
admet-327	50	40	around	around	ADP
admet-327	50	41	the	the	DET
admet-327	50	42	mean	mean	NOUN
admet-327	50	43	0.76±0.1	0.76±0.1	NOUN
admet-327	51	1	mm	mm	INTJ
admet-327	51	2	.	.	PUNCT
admet-327	52	1	on	on	ADP
admet-327	52	2	the	the	DET
admet-327	52	3	other	other	ADJ
admet-327	52	4	hand	hand	NOUN
admet-327	52	5	,	,	PUNCT
admet-327	52	6	the	the	DET
admet-327	52	7	human	human	ADJ
admet-327	52	8	counterpart	counterpart	NOUN
admet-327	52	9	aks	ak	NOUN
admet-327	52	10	exhibit	exhibit	VERB
admet-327	52	11	more	more	ADV
admet-327	52	12	diverse	diverse	ADJ
admet-327	52	13	values	value	NOUN
admet-327	52	14	.	.	PUNCT
admet-327	53	1	human	human	ADJ
admet-327	53	2	ak	ak	PROPN
admet-327	53	3	isoenzyme	isoenzyme	NOUN
admet-327	53	4	2	2	NUM
admet-327	53	5	(	(	PUNCT
admet-327	53	6	2c9y	2c9y	NOUN
admet-327	53	7	)	)	PUNCT
admet-327	53	8	–	–	PUNCT
admet-327	53	9	mitochondrial	mitochondrial	ADJ
admet-327	53	10	origin	origin	NOUN
admet-327	53	11	–	–	PUNCT
admet-327	53	12	exhibits	exhibit	VERB
admet-327	53	13	values	value	NOUN
admet-327	53	14	similar	similar	ADJ
admet-327	53	15	to	to	ADP
admet-327	53	16	enzymes	enzyme	NOUN
admet-327	53	17	of	of	ADP
admet-327	53	18	bacterial	bacterial	ADJ
admet-327	53	19	sources	source	NOUN
admet-327	53	20	.	.	PUNCT
admet-327	54	1	active	active	ADJ
admet-327	54	2	sites	site	NOUN
admet-327	54	3	residues	residue	NOUN
admet-327	54	4	which	which	PRON
admet-327	54	5	interact	interact	VERB
admet-327	54	6	with	with	ADP
admet-327	54	7	the	the	DET
admet-327	54	8	ligand	ligand	ADJ
admet-327	54	9	2,4	2,4	NUM
admet-327	54	10	-	-	PUNCT
admet-327	54	11	thiazolidinedione	thiazolidinedione	NOUN
admet-327	54	12	are	be	AUX
admet-327	54	13	shown	show	VERB
admet-327	54	14	in	in	ADP
admet-327	54	15	the	the	DET
admet-327	54	16	table	table	NOUN
admet-327	54	17	3	3	NUM
admet-327	54	18	.	.	PUNCT
admet-327	55	1	the	the	DET
admet-327	55	2	most	most	ADV
admet-327	55	3	striking	striking	ADJ
admet-327	55	4	observation	observation	NOUN
admet-327	55	5	is	be	AUX
admet-327	55	6	related	relate	VERB
admet-327	55	7	to	to	ADP
admet-327	55	8	aks	ak	NOUN
admet-327	55	9	of	of	ADP
admet-327	55	10	human	human	ADJ
admet-327	55	11	origin	origin	NOUN
admet-327	55	12	,	,	PUNCT
admet-327	55	13	as	as	SCONJ
admet-327	55	14	it	it	PRON
admet-327	55	15	is	be	AUX
admet-327	55	16	illustrated	illustrate	VERB
admet-327	55	17	in	in	ADP
admet-327	55	18	the	the	DET
admet-327	55	19	figures	figure	NOUN
admet-327	55	20	1	1	NUM
admet-327	55	21	and	and	CCONJ
admet-327	55	22	2	2	NUM
admet-327	55	23	.	.	X
admet-327	56	1	the	the	DET
admet-327	56	2	ak5	ak5	NOUN
admet-327	56	3	(	(	PUNCT
admet-327	56	4	2bwj	2bwj	NUM
admet-327	56	5	)	)	PUNCT
admet-327	56	6	–	–	PUNCT
admet-327	56	7	expressed	express	VERB
admet-327	56	8	exclusively	exclusively	ADV
admet-327	56	9	in	in	ADP
admet-327	56	10	the	the	DET
admet-327	56	11	brain	brain	NOUN
admet-327	57	1	[	[	X
admet-327	57	2	25	25	NUM
admet-327	57	3	]	]	PUNCT
admet-327	57	4	–	–	PUNCT
admet-327	57	5	is	be	AUX
admet-327	57	6	clearly	clearly	ADV
admet-327	57	7	a	a	DET
admet-327	57	8	poor	poor	ADJ
admet-327	57	9	target	target	NOUN
admet-327	57	10	,	,	PUNCT
admet-327	57	11	none	none	NOUN
admet-327	57	12	of	of	ADP
admet-327	57	13	the	the	DET
admet-327	57	14	residues	residue	NOUN
admet-327	57	15	from	from	ADP
admet-327	57	16	the	the	DET
admet-327	57	17	active	active	ADJ
admet-327	57	18	site	site	NOUN
admet-327	57	19	being	be	AUX
admet-327	57	20	involved	involve	VERB
admet-327	57	21	in	in	ADP
admet-327	57	22	2,4	2,4	NUM
admet-327	57	23	-	-	PUNCT
admet-327	57	24	thiazolidinedione	thiazolidinedione	ADJ
admet-327	57	25	binding	binding	NOUN
admet-327	57	26	.	.	PUNCT
admet-327	58	1	further	far	ADV
admet-327	58	2	,	,	PUNCT
admet-327	58	3	in	in	ADP
admet-327	58	4	the	the	DET
admet-327	58	5	case	case	NOUN
admet-327	58	6	of	of	ADP
admet-327	58	7	ak2	ak2	NOUN
admet-327	58	8	(	(	PUNCT
admet-327	58	9	2c9y	2c9y	NOUN
admet-327	58	10	)	)	PUNCT
admet-327	58	11	,	,	PUNCT
admet-327	58	12	the	the	DET
admet-327	58	13	ligand	ligand	NOUN
admet-327	58	14	forms	form	VERB
admet-327	58	15	standard	standard	ADJ
admet-327	58	16	hydrogen	hydrogen	NOUN
admet-327	58	17	bonds	bond	NOUN
admet-327	58	18	with	with	ADP
admet-327	58	19	two	two	NUM
admet-327	58	20	nonpolar	nonpolar	ADJ
admet-327	58	21	residues	residue	NOUN
admet-327	58	22	from	from	ADP
admet-327	58	23	amp	amp	NOUN
admet-327	58	24	-	-	PUNCT
admet-327	58	25	binding	bind	VERB
admet-327	58	26	region	region	NOUN
admet-327	58	27	(	(	PUNCT
admet-327	58	28	gly100	gly100	NOUN
admet-327	58	29	and	and	CCONJ
admet-327	58	30	phe101	phe101	PROPN
admet-327	58	31	)	)	PUNCT
admet-327	58	32	and	and	CCONJ
admet-327	58	33	with	with	ADP
admet-327	58	34	lys28	lys28	PROPN
admet-327	58	35	from	from	ADP
admet-327	58	36	atp	atp	NOUN
admet-327	58	37	-	-	PUNCT
admet-327	58	38	binding	bind	VERB
admet-327	58	39	domain	domain	NOUN
admet-327	58	40	.	.	PUNCT
admet-327	59	1	besides	besides	SCONJ
admet-327	59	2	,	,	PUNCT
admet-327	59	3	from	from	ADP
admet-327	59	4	the	the	DET
admet-327	59	5	aks	ak	NOUN
admet-327	59	6	examined	examine	VERB
admet-327	59	7	in	in	ADP
admet-327	59	8	the	the	DET
admet-327	59	9	present	present	ADJ
admet-327	59	10	study	study	NOUN
admet-327	59	11	,	,	PUNCT
admet-327	59	12	ak2	ak2	NOUN
admet-327	59	13	and	and	CCONJ
admet-327	59	14	one	one	NUM
admet-327	59	15	ak	ak	PROPN
admet-327	59	16	from	from	ADP
admet-327	59	17	e.	e.	PROPN
admet-327	59	18	coli	coli	PROPN
admet-327	59	19	3hpq	3hpq	PROPN
admet-327	59	20	are	be	AUX
admet-327	59	21	the	the	DET
admet-327	59	22	only	only	ADJ
admet-327	59	23	ones	one	NOUN
admet-327	59	24	which	which	PRON
admet-327	59	25	bind	bind	VERB
admet-327	59	26	2,4	2,4	NUM
admet-327	59	27	-	-	PUNCT
admet-327	59	28	thiazolidinedione	thiazolidinedione	NOUN
admet-327	59	29	with	with	ADP
admet-327	59	30	p	p	NOUN
admet-327	59	31	-	-	PUNCT
admet-327	59	32	loop	loop	NOUN
admet-327	59	33	domain	domain	NOUN
admet-327	59	34	residues	residue	NOUN
admet-327	59	35	(	(	PUNCT
admet-327	59	36	lys28	lys28	NOUN
admet-327	59	37	and	and	CCONJ
admet-327	59	38	lys13	lys13	PROPN
admet-327	59	39	,	,	PUNCT
admet-327	59	40	respectively	respectively	ADV
admet-327	59	41	)	)	PUNCT
admet-327	59	42	.	.	PUNCT
admet-327	60	1	notably	notably	ADV
admet-327	60	2	,	,	PUNCT
admet-327	60	3	the	the	DET
admet-327	60	4	same	same	ADJ
admet-327	60	5	oxygen	oxygen	NOUN
admet-327	60	6	atom	atom	NOUN
admet-327	60	7	(	(	PUNCT
admet-327	60	8	o2	o2	PROPN
admet-327	60	9	)	)	PUNCT
admet-327	60	10	(	(	PUNCT
admet-327	60	11	scheme	scheme	NOUN
admet-327	60	12	1	1	NUM
admet-327	60	13	)	)	PUNCT
admet-327	60	14	of	of	ADP
admet-327	60	15	the	the	DET
admet-327	60	16	ligand	ligand	NOUN
admet-327	60	17	forms	form	VERB
admet-327	60	18	hydrogen	hydrogen	NOUN
admet-327	60	19	bond	bond	NOUN
admet-327	60	20	with	with	ADP
admet-327	60	21	lysine	lysine	NOUN
admet-327	60	22	but	but	CCONJ
admet-327	60	23	different	different	ADJ
admet-327	60	24	atoms	atom	NOUN
admet-327	60	25	are	be	AUX
admet-327	60	26	involved	involve	VERB
admet-327	60	27	–	–	PUNCT
admet-327	60	28	nz	nz	PROPN
admet-327	60	29	regarding	regard	VERB
admet-327	60	30	2c9y	2c9y	PROPN
admet-327	60	31	and	and	CCONJ
admet-327	60	32	ce	ce	PROPN
admet-327	60	33	for	for	ADP
admet-327	60	34	3hpq	3hpq	PROPN
admet-327	60	35	(	(	PUNCT
admet-327	60	36	figures	figure	NOUN
admet-327	60	37	3	3	NUM
admet-327	60	38	and	and	CCONJ
admet-327	60	39	4	4	NUM
admet-327	60	40	)	)	PUNCT
admet-327	60	41	.	.	PUNCT
admet-327	61	1	on	on	ADP
admet-327	61	2	the	the	DET
admet-327	61	3	contrary	contrary	NOUN
admet-327	61	4	,	,	PUNCT
admet-327	61	5	apart	apart	ADV
admet-327	61	6	from	from	ADP
admet-327	61	7	the	the	DET
admet-327	61	8	residues	residue	NOUN
admet-327	61	9	involved	involve	VERB
admet-327	61	10	in	in	ADP
admet-327	61	11	amp	amp	NOUN
admet-327	61	12	-	-	PUNCT
admet-327	61	13	binding	bind	VERB
admet-327	61	14	,	,	PUNCT
admet-327	61	15	ak1	ak1	PROPN
admet-327	61	16	shows	show	VERB
admet-327	61	17	only	only	ADV
admet-327	61	18	a	a	DET
admet-327	61	19	glycine	glycine	NOUN
admet-327	61	20	from	from	ADP
admet-327	61	21	nmp	nmp	NOUN
admet-327	61	22	-	-	PUNCT
admet-327	61	23	binding	bind	VERB
admet-327	61	24	domain	domain	NOUN
admet-327	61	25	which	which	PRON
admet-327	61	26	binds	bind	VERB
admet-327	61	27	the	the	DET
admet-327	61	28	ligand	ligand	NOUN
admet-327	61	29	.	.	PUNCT
admet-327	62	1	this	this	PRON
admet-327	62	2	might	might	AUX
admet-327	62	3	be	be	AUX
admet-327	62	4	a	a	DET
admet-327	62	5	reasonable	reasonable	ADJ
admet-327	62	6	explanation	explanation	NOUN
admet-327	62	7	of	of	ADP
admet-327	62	8	almost	almost	ADV
admet-327	62	9	twofold	twofold	ADV
admet-327	62	10	value	value	NOUN
admet-327	62	11	ki	ki	PROPN
admet-327	62	12	of	of	ADP
admet-327	62	13	ak1	ak1	PROPN
admet-327	62	14	(	(	PUNCT
admet-327	62	15	1.99	1.99	NUM
admet-327	62	16	mm	mm	NOUN
admet-327	62	17	)	)	PUNCT
admet-327	62	18	compared	compare	VERB
admet-327	62	19	with	with	ADP
admet-327	62	20	ak2	ak2	NOUN
admet-327	62	21	(	(	PUNCT
admet-327	62	22	0.84	0.84	NUM
admet-327	62	23	mm	mm	NOUN
admet-327	62	24	)	)	PUNCT
admet-327	62	25	.	.	PUNCT
admet-327	63	1	a	a	DET
admet-327	63	2	unique	unique	ADJ
admet-327	63	3	detail	detail	NOUN
admet-327	63	4	is	be	AUX
admet-327	63	5	observed	observe	VERB
admet-327	63	6	in	in	ADP
admet-327	63	7	the	the	DET
admet-327	63	8	case	case	NOUN
admet-327	63	9	of	of	ADP
admet-327	63	10	gram	gram	NOUN
admet-327	63	11	-	-	PUNCT
admet-327	63	12	positive	positive	ADJ
admet-327	63	13	and	and	CCONJ
admet-327	63	14	acid	acid	ADJ
admet-327	63	15	fast	fast	ADJ
admet-327	63	16	aks	ak	NOUN
admet-327	63	17	–	–	PUNCT
admet-327	63	18	a	a	DET
admet-327	63	19	favorable	favorable	ADJ
admet-327	63	20	interaction	interaction	NOUN
admet-327	63	21	between	between	ADP
admet-327	63	22	pi	pi	NOUN
admet-327	63	23	-	-	PUNCT
admet-327	63	24	sulfur	sulfur	NOUN
admet-327	63	25	of	of	ADP
admet-327	63	26	the	the	DET
admet-327	63	27	ligand	ligand	NOUN
admet-327	63	28	and	and	CCONJ
admet-327	63	29	the	the	DET
admet-327	63	30	nonpolar	nonpolar	ADJ
admet-327	63	31	residue	residue	NOUN
admet-327	63	32	phe35	phe35	NOUN
admet-327	63	33	from	from	ADP
admet-327	63	34	nmp	nmp	NOUN
admet-327	63	35	-	-	PUNCT
admet-327	63	36	binding	bind	VERB
admet-327	63	37	domain	domain	NOUN
admet-327	63	38	(	(	PUNCT
admet-327	63	39	figures	figure	NOUN
admet-327	63	40	5	5	NUM
admet-327	63	41	and	and	CCONJ
admet-327	63	42	mihaela	mihaela	PROPN
admet-327	63	43	i.	i.	PROPN
admet-327	63	44	ionescu	ionescu	PROPN
admet-327	63	45	admet	admet	PROPN
admet-327	63	46	&	&	CCONJ
admet-327	63	47	dmpk	dmpk	PROPN
admet-327	63	48	5(1	5(1	NUM
admet-327	63	49	)	)	PUNCT
admet-327	63	50	(	(	PUNCT
admet-327	63	51	2017	2017	NUM
admet-327	63	52	)	)	PUNCT
admet-327	63	53	47	47	NUM
admet-327	63	54	-	-	SYM
admet-327	63	55	56	56	NUM
admet-327	63	56	50	50	NUM
admet-327	63	57	6	6	NUM
admet-327	63	58	)	)	PUNCT
admet-327	63	59	might	might	AUX
admet-327	63	60	play	play	VERB
admet-327	63	61	an	an	DET
admet-327	63	62	important	important	ADJ
admet-327	63	63	role	role	NOUN
admet-327	63	64	in	in	ADP
admet-327	63	65	stabilization	stabilization	NOUN
admet-327	63	66	of	of	ADP
admet-327	63	67	ak-2,4	ak-2,4	ADJ
admet-327	63	68	-	-	PUNCT
admet-327	63	69	thiazolidinedione	thiazolidinedione	ADJ
admet-327	63	70	complex	complex	NOUN
admet-327	64	1	[	[	X
admet-327	64	2	26	26	NUM
admet-327	64	3	]	]	PUNCT
admet-327	64	4	.	.	PUNCT
admet-327	65	1	multiple	multiple	ADJ
admet-327	65	2	sequence	sequence	NOUN
admet-327	65	3	alignment	alignment	NOUN
admet-327	65	4	exhibits	exhibit	VERB
admet-327	65	5	a	a	DET
admet-327	65	6	conservative	conservative	ADJ
admet-327	65	7	replacement	replacement	NOUN
admet-327	65	8	of	of	ADP
admet-327	65	9	phe35	phe35	PROPN
admet-327	65	10	with	with	ADP
admet-327	65	11	leucine	leucine	NOUN
admet-327	65	12	on	on	ADP
admet-327	65	13	other	other	ADJ
admet-327	65	14	aks	ak	NOUN
admet-327	65	15	.	.	PUNCT
admet-327	66	1	moreover	moreover	ADV
admet-327	66	2	,	,	PUNCT
admet-327	66	3	in	in	ADP
admet-327	66	4	a.	a.	PROPN
admet-327	66	5	aeolicus	aeolicus	PROPN
admet-327	66	6	’	'	PUNCT
admet-327	66	7	ak	ak	PROPN
admet-327	66	8	,	,	PUNCT
admet-327	66	9	van	van	PROPN
admet-327	66	10	der	der	NOUN
admet-327	66	11	waals	waal	NOUN
admet-327	66	12	’	'	PUNCT
admet-327	66	13	forces	force	NOUN
admet-327	66	14	between	between	ADP
admet-327	66	15	leu35	leu35	PROPN
admet-327	66	16	and	and	CCONJ
admet-327	66	17	the	the	DET
admet-327	66	18	only	only	ADJ
admet-327	66	19	sulfur	sulfur	NOUN
admet-327	66	20	atom	atom	NOUN
admet-327	66	21	of	of	ADP
admet-327	66	22	the	the	DET
admet-327	66	23	ligand	ligand	NOUN
admet-327	66	24	are	be	AUX
admet-327	66	25	noticed	notice	VERB
admet-327	66	26	.	.	PUNCT
admet-327	67	1	table	table	NOUN
admet-327	67	2	2	2	NUM
admet-327	67	3	.	.	PUNCT
admet-327	68	1	energy	energy	NOUN
admet-327	68	2	binding	bind	VERB
admet-327	68	3	and	and	CCONJ
admet-327	68	4	inhibition	inhibition	VERB
admet-327	68	5	constant	constant	ADJ
admet-327	68	6	(	(	PUNCT
admet-327	68	7	ki	ki	PROPN
admet-327	68	8	)	)	PUNCT
admet-327	68	9	of	of	ADP
admet-327	68	10	the	the	DET
admet-327	68	11	best	good	ADJ
admet-327	68	12	conformation	conformation	NOUN
admet-327	68	13	of	of	ADP
admet-327	68	14	the	the	DET
admet-327	68	15	complex	complex	ADJ
admet-327	68	16	ak2	ak2	NOUN
admet-327	68	17	,	,	PUNCT
admet-327	68	18	4	4	NUM
admet-327	68	19	-	-	SYM
admet-327	68	20	thiazolidinedione	thiazolidinedione	NUM
admet-327	68	21	ak	ak	PROPN
admet-327	68	22	∆g	∆g	PROPN
admet-327	68	23	,	,	PUNCT
admet-327	68	24	kcal	kcal	PROPN
admet-327	68	25	/	/	SYM
admet-327	68	26	mol	mol	ADP
admet-327	68	27	ki	ki	PROPN
admet-327	68	28	,	,	PUNCT
admet-327	68	29	mm	mm	PROPN
admet-327	68	30	scheme	scheme	NOUN
admet-327	68	31	1	1	NUM
admet-327	68	32	.	.	PUNCT
admet-327	69	1	the	the	DET
admet-327	69	2	numbering	numbering	NOUN
admet-327	69	3	of	of	ADP
admet-327	69	4	2,4	2,4	NUM
admet-327	69	5	-	-	PUNCT
admet-327	69	6	thiazolidinedione	thiazolidinedione	ADJ
admet-327	69	7	atoms	atom	NOUN
admet-327	69	8	gram	gram	NOUN
admet-327	69	9	-	-	PUNCT
admet-327	69	10	negative	negative	ADJ
admet-327	69	11	bacteria	bacteria	NOUN
admet-327	69	12	3hpq	3hpq	PROPN
admet-327	69	13	-4.0	-4.0	PROPN
admet-327	69	14	1.17	1.17	NUM
admet-327	69	15	1ank	1ank	NUM
admet-327	69	16	-4.18	-4.18	NUM
admet-327	69	17	0.86	0.86	NUM
admet-327	69	18	2rgx	2rgx	PROPN
admet-327	69	19	-4.22	-4.22	NUM
admet-327	69	20	0.81	0.81	NUM
admet-327	69	21	mean	mean	NOUN
admet-327	69	22	±	±	NUM
admet-327	69	23	sd	sd	ADP
admet-327	69	24	-4.13±0.09	-4.13±0.09	NUM
admet-327	69	25	0.94±0.16	0.94±0.16	PROPN
admet-327	69	26	gram	gram	PROPN
admet-327	69	27	-	-	PUNCT
admet-327	69	28	positive	positive	ADJ
admet-327	69	29	and	and	CCONJ
admet-327	69	30	acid	acid	ADJ
admet-327	69	31	fast	fast	ADJ
admet-327	69	32	bacteria	bacteria	NOUN
admet-327	69	33	1zip	1zip	NUM
admet-327	69	34	-4.36	-4.36	NUM
admet-327	69	35	0.64	0.64	NUM
admet-327	69	36	4w5j	4w5j	NOUN
admet-327	69	37	-4.27	-4.27	NOUN
admet-327	70	1	0.77	0.77	NUM
admet-327	70	2	2cdn	2cdn	NUM
admet-327	70	3	-4.16	-4.16	NUM
admet-327	70	4	0.89	0.89	NUM
admet-327	70	5	mean	mean	NOUN
admet-327	70	6	±	±	NUM
admet-327	70	7	sd	sd	ADP
admet-327	70	8	-4.26±0.08	-4.26±0.08	PROPN
admet-327	70	9	0.76±0.1	0.76±0.1	NUM
admet-327	70	10	homo	homo	NOUN
admet-327	70	11	sapiens	sapien	VERB
admet-327	70	12	2c95	2c95	NUM
admet-327	70	13	-3.68	-3.68	NUM
admet-327	70	14	1.99	1.99	NUM
admet-327	70	15	2c9y	2c9y	NOUN
admet-327	70	16	-4.19	-4.19	NUM
admet-327	70	17	0.84	0.84	NUM
admet-327	70	18	2bwj	2bwj	NUM
admet-327	70	19	-2.8	-2.8	NOUN
admet-327	70	20	8.8	8.8	NUM
admet-327	70	21	mean	mean	NOUN
admet-327	70	22	±	±	NUM
admet-327	70	23	sd	sd	ADP
admet-327	70	24	-3.56±0.57	-3.56±0.57	PROPN
admet-327	70	25	3.88±3.51	3.88±3.51	NUM
admet-327	70	26	total	total	ADJ
admet-327	70	27	mean	mean	NOUN
admet-327	70	28	±	±	PROPN
admet-327	70	29	sd	sd	ADP
admet-327	70	30	-3.98	-3.98	NUM
admet-327	70	31	±	±	NUM
admet-327	70	32	0.46	0.46	NUM
admet-327	70	33	1.86	1.86	NUM
admet-327	70	34	±	±	NUM
admet-327	70	35	2.48	2.48	NUM
admet-327	70	36	table	table	NOUN
admet-327	70	37	3	3	NUM
admet-327	70	38	.	.	NOUN
admet-327	70	39	residues	residue	NOUN
admet-327	70	40	of	of	ADP
admet-327	70	41	substrate	substrate	NOUN
admet-327	70	42	binding	bind	VERB
admet-327	70	43	domains	domain	NOUN
admet-327	70	44	,	,	PUNCT
admet-327	70	45	according	accord	VERB
admet-327	70	46	to	to	ADP
admet-327	70	47	protein	protein	NOUN
admet-327	70	48	database	database	NOUN
admet-327	70	49	(	(	PUNCT
admet-327	70	50	www.rcsb.org/pdb/home/home.do	www.rcsb.org/pdb/home/home.do	NOUN
admet-327	70	51	)	)	PUNCT
admet-327	70	52	details	detail	NOUN
admet-327	70	53	code	code	NOUN
admet-327	70	54	color	color	NOUN
admet-327	70	55	for	for	ADP
admet-327	70	56	interactions	interaction	NOUN
admet-327	70	57	with	with	ADP
admet-327	70	58	2,4	2,4	NUM
admet-327	70	59	-	-	PUNCT
admet-327	70	60	thiazolidinedione	thiazolidinedione	NOUN
admet-327	70	61	:	:	PUNCT
admet-327	70	62	in	in	ADP
admet-327	70	63	green	green	ADJ
admet-327	70	64	are	be	AUX
admet-327	70	65	shown	show	VERB
admet-327	70	66	conventional	conventional	ADJ
admet-327	70	67	hydrogen	hydrogen	NOUN
admet-327	70	68	bonds	bond	NOUN
admet-327	70	69	;	;	PUNCT
admet-327	70	70	blue	blue	ADJ
admet-327	70	71	–	–	PUNCT
admet-327	70	72	van	van	PROPN
admet-327	70	73	der	der	NOUN
admet-327	70	74	waals	waal	NOUN
admet-327	70	75	’	'	PUNCT
admet-327	70	76	forces	force	NOUN
admet-327	70	77	,	,	PUNCT
admet-327	70	78	brown	brown	ADJ
admet-327	70	79	–	–	PUNCT
admet-327	70	80	carbon	carbon	NOUN
admet-327	70	81	hydrogen	hydrogen	NOUN
admet-327	70	82	bonds	bond	NOUN
admet-327	70	83	;	;	PUNCT
admet-327	71	1	orange	orange	ADJ
admet-327	71	2	–	–	PUNCT
admet-327	71	3	pi	pi	NOUN
admet-327	71	4	-	-	PUNCT
admet-327	71	5	sulfur	sulfur	NOUN
admet-327	71	6	,	,	PUNCT
admet-327	71	7	red	red	ADJ
admet-327	71	8	–	–	PUNCT
admet-327	71	9	unfavorable	unfavorable	ADJ
admet-327	71	10	acceptor	acceptor	NOUN
admet-327	71	11	-	-	PUNCT
admet-327	71	12	acceptor	acceptor	NOUN
admet-327	71	13	ak	ak	PROPN
admet-327	71	14	nmp	nmp	PROPN
admet-327	71	15	-	-	PUNCT
admet-327	71	16	binding	bind	VERB
admet-327	71	17	domain	domain	NOUN
admet-327	71	18	amp	amp	NOUN
admet-327	71	19	binding	bind	VERB
admet-327	71	20	lid	lid	NOUN
admet-327	71	21	domain	domain	NOUN
admet-327	71	22	atp	atp	NOUN
admet-327	71	23	binding	bind	VERB
admet-327	71	24	(	(	PUNCT
admet-327	71	25	p	p	NOUN
admet-327	71	26	-	-	PUNCT
admet-327	71	27	loop	loop	NOUN
admet-327	71	28	)	)	PUNCT
admet-327	71	29	3hpq	3hpq	PROPN
admet-327	71	30	ser30	ser30	ADJ
admet-327	71	31	-	-	PUNCT
admet-327	71	32	val60	val60	VERB
admet-327	71	33	lys57	lys57	PROPN
admet-327	71	34	-	-	PUNCT
admet-327	71	35	val59	val59	PROPN
admet-327	71	36	,	,	PUNCT
admet-327	71	37	gly85-(phe86	gly85-(phe86	PROPN
admet-327	71	38	,	,	PUNCT
admet-327	71	39	pro87)arg88	pro87)arg88	ADJ
admet-327	71	40	,	,	PUNCT
admet-327	71	41	thr31	thr31	NOUN
admet-327	71	42	,	,	PUNCT
admet-327	71	43	arg36	arg36	PROPN
admet-327	71	44	,	,	PUNCT
admet-327	71	45	gln92	gln92	PROPN
admet-327	71	46	,	,	PUNCT
admet-327	71	47	arg167	arg167	PROPN
admet-327	71	48	gly122	gly122	PROPN
admet-327	71	49	-	-	PUNCT
admet-327	71	50	asp159	asp159	PROPN
admet-327	71	51	gly10-(lys13)-thr15	gly10-(lys13)-thr15	PROPN
admet-327	71	52	,	,	PUNCT
admet-327	71	53	val132tyr133	val132tyr133	PROPN
admet-327	71	54	,	,	PUNCT
admet-327	71	55	arg119	arg119	PROPN
admet-327	71	56	,	,	PUNCT
admet-327	71	57	arg123	arg123	NOUN
admet-327	71	58	,	,	PUNCT
admet-327	71	59	lys200	lys200	PROPN
admet-327	71	60	1ank	1ank	NUM
admet-327	71	61	ser30-(leu58)val59	ser30-(leu58)val59	PROPN
admet-327	71	62	lys57-(leu58)-val59	lys57-(leu58)-val59	PROPN
admet-327	71	63	,	,	PUNCT
admet-327	71	64	gly85-(phe86)arg88	gly85-(phe86)arg88	NOUN
admet-327	71	65	,	,	PUNCT
admet-327	71	66	thr31	thr31	NOUN
admet-327	71	67	,	,	PUNCT
admet-327	71	68	arg36	arg36	PROPN
admet-327	71	69	,	,	PUNCT
admet-327	71	70	gln92	gln92	PROPN
admet-327	71	71	,	,	PUNCT
admet-327	71	72	thr156	thr156	PROPN
admet-327	71	73	,	,	PUNCT
admet-327	71	74	arg167	arg167	PROPN
admet-327	71	75	gly122	gly122	PROPN
admet-327	71	76	-	-	PUNCT
admet-327	71	77	asp159	asp159	PROPN
admet-327	71	78	gly10	gly10	NOUN
admet-327	71	79	-	-	PUNCT
admet-327	71	80	thr15	thr15	NOUN
admet-327	71	81	,	,	PUNCT
admet-327	71	82	val132	val132	PROPN
admet-327	71	83	-	-	PUNCT
admet-327	71	84	tyr133	tyr133	PROPN
admet-327	71	85	,	,	PUNCT
admet-327	71	86	arg119	arg119	PROPN
admet-327	71	87	,	,	PUNCT
admet-327	71	88	arg123	arg123	NOUN
admet-327	71	89	,	,	PUNCT
admet-327	71	90	lys200	lys200	PROPN
admet-327	71	91	2rgx	2rgx	PROPN
admet-327	71	92	ser30-(thr31	ser30-(thr31	PROPN
admet-327	71	93	/	/	SYM
admet-327	71	94	thr31	thr31	NOUN
admet-327	71	95	,	,	PUNCT
admet-327	71	96	leu35	leu35	PROPN
admet-327	71	97	,	,	PUNCT
admet-327	71	98	leu58)-val59	leu58)-val59	PROPN
admet-327	71	99	glu57	glu57	PROPN
admet-327	71	100	-	-	PUNCT
admet-327	71	101	val59	val59	PROPN
admet-327	71	102	,	,	PUNCT
admet-327	71	103	gly82	gly82	NOUN
admet-327	71	104	,	,	PUNCT
admet-327	71	105	phe83	phe83	PROPN
admet-327	71	106	,	,	PUNCT
admet-327	71	107	pro84	pro84	NOUN
admet-327	71	108	,	,	PUNCT
admet-327	71	109	arg85	arg85	NOUN
admet-327	71	110	,	,	PUNCT
admet-327	71	111	thr31	thr31	ADJ
admet-327	71	112	/	/	SYM
admet-327	71	113	thr31	thr31	NOUN
admet-327	71	114	,	,	PUNCT
admet-327	71	115	gln89	gln89	PROPN
admet-327	71	116	,	,	PUNCT
admet-327	71	117	arg131	arg131	PROPN
admet-327	71	118	gly123	gly123	PROPN
admet-327	71	119	-	-	PUNCT
admet-327	71	120	asp153	asp153	PROPN
admet-327	71	121	gly10	gly10	NOUN
admet-327	71	122	-	-	PUNCT
admet-327	71	123	thr15	thr15	NOUN
admet-327	71	124	,	,	PUNCT
admet-327	71	125	val133	val133	PROPN
admet-327	71	126	-	-	PUNCT
admet-327	71	127	tyr134	tyr134	PROPN
admet-327	71	128	,	,	PUNCT
admet-327	71	129	arg120	arg120	PROPN
admet-327	71	130	,	,	PUNCT
admet-327	71	131	arg124	arg124	PROPN
admet-327	71	132	,	,	PUNCT
admet-327	71	133	lys189	lys189	PROPN
admet-327	71	134	1zip	1zip	NUM
admet-327	71	135	ser30-(thr31	ser30-(thr31	PROPN
admet-327	71	136	,	,	PUNCT
admet-327	71	137	phe35	phe35	PROPN
admet-327	71	138	,	,	PUNCT
admet-327	71	139	leu58)-val59	leu58)-val59	PROPN
admet-327	71	140	asp57-(leu58)-val59	asp57-(leu58)-val59	PROPN
admet-327	71	141	,	,	PUNCT
admet-327	71	142	gly85	gly85	NOUN
admet-327	71	143	-	-	PUNCT
admet-327	71	144	arg88	arg88	NOUN
admet-327	71	145	,	,	PUNCT
admet-327	71	146	ser30	ser30	ADJ
admet-327	71	147	,	,	PUNCT
admet-327	71	148	arg36	arg36	PROPN
admet-327	71	149	,	,	PUNCT
admet-327	71	150	gln92	gln92	PROPN
admet-327	71	151	,	,	PUNCT
admet-327	71	152	gln159	gln159	PROPN
admet-327	71	153	,	,	PUNCT
admet-327	71	154	arg171	arg171	PROPN
admet-327	71	155	gly126	gly126	NOUN
admet-327	71	156	-	-	PUNCT
admet-327	71	157	asp163	asp163	ADJ
admet-327	71	158	gly10	gly10	NOUN
admet-327	71	159	-	-	PUNCT
admet-327	71	160	thr15	thr15	NOUN
admet-327	71	161	,	,	PUNCT
admet-327	71	162	thr136	thr136	NOUN
admet-327	71	163	-	-	PUNCT
admet-327	71	164	tyr137	tyr137	NOUN
admet-327	71	165	,	,	PUNCT
admet-327	71	166	arg127	arg127	PROPN
admet-327	71	167	,	,	PUNCT
admet-327	71	168	gln199	gln199	PROPN
admet-327	71	169	4w5j	4w5j	NOUN
admet-327	71	170	ser30-(phe35)val59	ser30-(phe35)val59	NUM
admet-327	71	171	glu57-(leu58)-val59	glu57-(leu58)-val59	PROPN
admet-327	71	172	,	,	PUNCT
admet-327	71	173	gly85-(gly86	gly85-(gly86	PROPN
admet-327	71	174	,	,	PUNCT
admet-327	71	175	tyr87)-arg88	tyr87)-arg88	PROPN
admet-327	71	176	,	,	PUNCT
admet-327	71	177	thr31	thr31	NOUN
admet-327	71	178	,	,	PUNCT
admet-327	71	179	arg36	arg36	PROPN
admet-327	71	180	,	,	PUNCT
admet-327	71	181	gln93	gln93	NOUN
admet-327	71	182	,	,	PUNCT
admet-327	71	183	arg156	arg156	NOUN
admet-327	71	184	,	,	PUNCT
admet-327	71	185	arg167	arg167	PROPN
admet-327	71	186	gly127	gly127	PROPN
admet-327	71	187	-	-	PUNCT
admet-327	71	188	asp159	asp159	NOUN
admet-327	71	189	gly10	gly10	NOUN
admet-327	71	190	-	-	PUNCT
admet-327	71	191	thr15	thr15	NOUN
admet-327	71	192	,	,	PUNCT
admet-327	71	193	thr137	thr137	PROPN
admet-327	71	194	-	-	PUNCT
admet-327	71	195	phe138	phe138	PROPN
admet-327	71	196	,	,	PUNCT
admet-327	71	197	arg128	arg128	NOUN
admet-327	71	198	,	,	PUNCT
admet-327	71	199	gln195	gln195	PROPN
admet-327	71	200	2cdn	2cdn	PROPN
admet-327	71	201	ser30-(phe35	ser30-(phe35	PROPN
admet-327	71	202	,	,	PUNCT
admet-327	71	203	leu58)val59	leu58)val59	PROPN
admet-327	71	204	asp57-(leu58)-val59	asp57-(leu58)-val59	PROPN
admet-327	71	205	,	,	PUNCT
admet-327	71	206	gly85-(tyr86)arg88	gly85-(tyr86)arg88	NOUN
admet-327	71	207	,	,	PUNCT
admet-327	71	208	thr31	thr31	NOUN
admet-327	71	209	,	,	PUNCT
admet-327	71	210	arg36	arg36	PROPN
admet-327	71	211	,	,	PUNCT
admet-327	71	212	gln92	gln92	PROPN
admet-327	71	213	,	,	PUNCT
admet-327	71	214	arg129	arg129	PROPN
admet-327	71	215	,	,	PUNCT
admet-327	71	216	arg140	arg140	PROPN
admet-327	71	217	gly126	gly126	PROPN
admet-327	71	218	-	-	PUNCT
admet-327	71	219	asp132	asp132	PROPN
admet-327	71	220	gly10	gly10	NOUN
admet-327	71	221	-	-	PUNCT
admet-327	71	222	thr15	thr15	NOUN
admet-327	71	223	,	,	PUNCT
admet-327	71	224	arg127	arg127	PROPN
admet-327	71	225	,	,	PUNCT
admet-327	71	226	gly166	gly166	PROPN
admet-327	71	227	2c95	2c95	ADV
admet-327	71	228	ser38-(gly40)val67	ser38-(gly40)val67	NUM
admet-327	71	229	gln65	gln65	NOUN
admet-327	71	230	-	-	PUNCT
admet-327	71	231	val67	val67	ADJ
admet-327	71	232	,	,	PUNCT
admet-327	71	233	gly94	gly94	NOUN
admet-327	71	234	-	-	PUNCT
admet-327	71	235	arg97	arg97	NOUN
admet-327	71	236	,	,	PUNCT
admet-327	71	237	thr39	thr39	ADJ
admet-327	71	238	,	,	PUNCT
admet-327	71	239	arg44	arg44	PROPN
admet-327	71	240	,	,	PUNCT
admet-327	71	241	gln101	gln101	PROPN
admet-327	71	242	,	,	PUNCT
admet-327	71	243	arg138	arg138	PROPN
admet-327	71	244	,	,	PUNCT
admet-327	71	245	arg149	arg149	PROPN
admet-327	71	246	lys131	lys131	PROPN
admet-327	71	247	-	-	PUNCT
admet-327	71	248	asp141	asp141	PROPN
admet-327	71	249	gly18	gly18	NOUN
admet-327	71	250	-	-	PUNCT
admet-327	71	251	thr23	thr23	NOUN
admet-327	71	252	,	,	PUNCT
admet-327	71	253	arg132	arg132	PROPN
admet-327	71	254	,	,	PUNCT
admet-327	71	255	gly177	gly177	PROPN
admet-327	71	256	2c9y	2c9y	NOUN
admet-327	71	257	ala45	ala45	NOUN
admet-327	71	258	-	-	PUNCT
admet-327	71	259	val74	val74	NOUN
admet-327	71	260	lys72	lys72	NOUN
admet-327	71	261	-	-	PUNCT
admet-327	71	262	val74	val74	NOUN
admet-327	71	263	,	,	PUNCT
admet-327	71	264	gly100	gly100	PROPN
admet-327	71	265	,	,	PUNCT
admet-327	71	266	phe101	phe101	PROPN
admet-327	71	267	,	,	PUNCT
admet-327	71	268	pro102	pro102	PROPN
admet-327	71	269	,	,	PUNCT
admet-327	71	270	arg103	arg103	PROPN
admet-327	71	271	,	,	PUNCT
admet-327	71	272	thr46	thr46	PROPN
admet-327	71	273	,	,	PUNCT
admet-327	71	274	arg51	arg51	PROPN
admet-327	71	275	,	,	PUNCT
admet-327	71	276	gln107	gln107	PROPN
admet-327	71	277	,	,	PUNCT
admet-327	71	278	arg175	arg175	PROPN
admet-327	71	279	,	,	PUNCT
admet-327	71	280	arg186	arg186	PROPN
admet-327	71	281	gly141	gly141	PROPN
admet-327	71	282	-	-	PUNCT
admet-327	71	283	asp178	asp178	PROPN
admet-327	71	284	gly25-(lys28)-thr30	gly25-(lys28)-thr30	PROPN
admet-327	71	285	,	,	PUNCT
admet-327	71	286	ser151tyr152	ser151tyr152	PROPN
admet-327	71	287	,	,	PUNCT
admet-327	71	288	arg138	arg138	PROPN
admet-327	71	289	,	,	PUNCT
admet-327	71	290	arg142	arg142	PROPN
admet-327	71	291	,	,	PUNCT
admet-327	71	292	gln214	gln214	PROPN
admet-327	71	293	2bwj	2bwj	NUM
admet-327	71	294	ser41	ser41	PROPN
admet-327	71	295	-	-	PUNCT
admet-327	71	296	val70	val70	NOUN
admet-327	71	297	asp68	asp68	NOUN
admet-327	71	298	-	-	PUNCT
admet-327	71	299	val70	val70	NOUN
admet-327	71	300	,	,	PUNCT
admet-327	71	301	gly97	gly97	NOUN
admet-327	71	302	-	-	PUNCT
admet-327	71	303	arg100	arg100	PROPN
admet-327	71	304	,	,	PUNCT
admet-327	71	305	thr42	thr42	PROPN
admet-327	71	306	,	,	PUNCT
admet-327	71	307	arg47	arg47	PROPN
admet-327	71	308	,	,	PUNCT
admet-327	71	309	arg104	arg104	PROPN
admet-327	71	310	,	,	PUNCT
admet-327	71	311	arg152	arg152	PROPN
admet-327	71	312	gln136	gln136	PROPN
admet-327	71	313	-	-	PUNCT
admet-327	71	314	asp144	asp144	PROPN
admet-327	71	315	gly21	gly21	PROPN
admet-327	71	316	-	-	PUNCT
admet-327	71	317	thr26	thr26	NOUN
admet-327	71	318	,	,	PUNCT
admet-327	71	319	arg135	arg135	PROPN
admet-327	71	320	,	,	PUNCT
admet-327	71	321	gly180	gly180	PROPN
admet-327	71	322	http://www.rcsb.org/pdb/home/home.do	http://www.rcsb.org/pdb/home/home.do	PROPN
admet-327	71	323	admet	admet	PROPN
admet-327	71	324	&	&	CCONJ
admet-327	71	325	dmpk	dmpk	PROPN
admet-327	71	326	5(1	5(1	NUM
admet-327	71	327	)	)	PUNCT
admet-327	71	328	(	(	PUNCT
admet-327	71	329	2017	2017	NUM
admet-327	71	330	)	)	PUNCT
admet-327	71	331	47	47	NUM
admet-327	71	332	-	-	SYM
admet-327	71	333	56	56	NUM
admet-327	71	334	adenylate	adenylate	ADJ
admet-327	71	335	kinase	kinase	NOUN
admet-327	71	336	inhibition	inhibition	NOUN
admet-327	71	337	by	by	ADP
admet-327	71	338	2,4	2,4	NUM
admet-327	71	339	-	-	PUNCT
admet-327	71	340	thiazolidinedione	thiazolidinedione	ADJ
admet-327	71	341	doi	doi	NOUN
admet-327	71	342	:	:	PUNCT
admet-327	71	343	10.5599	10.5599	NUM
admet-327	71	344	/	/	SYM
admet-327	71	345	admet.5.1.327	admet.5.1.327	PROPN
admet-327	71	346	51	51	NUM
admet-327	71	347	the	the	DET
admet-327	71	348	interactions	interaction	NOUN
admet-327	71	349	of	of	ADP
admet-327	71	350	2,4	2,4	NUM
admet-327	71	351	-	-	PUNCT
admet-327	71	352	thiazolidinedione	thiazolidinedione	NOUN
admet-327	71	353	with	with	ADP
admet-327	71	354	aks	ak	NOUN
admet-327	71	355	of	of	ADP
admet-327	71	356	gram	gram	NOUN
admet-327	71	357	-	-	PUNCT
admet-327	71	358	negative	negative	ADJ
admet-327	71	359	bacteria	bacteria	NOUN
admet-327	71	360	a.	a.	NOUN
admet-327	71	361	aeolicus	aeolicus	PROPN
admet-327	71	362	–	–	PUNCT
admet-327	71	363	a	a	DET
admet-327	71	364	hyperthermophilic	hyperthermophilic	ADJ
admet-327	71	365	species	specie	NOUN
admet-327	71	366	–	–	PUNCT
admet-327	71	367	and	and	CCONJ
admet-327	71	368	two	two	NUM
admet-327	71	369	structures	structure	NOUN
admet-327	71	370	from	from	ADP
admet-327	71	371	e.	e.	PROPN
admet-327	71	372	coli	coli	NOUN
admet-327	71	373	are	be	AUX
admet-327	71	374	shown	show	VERB
admet-327	71	375	in	in	ADP
admet-327	71	376	the	the	DET
admet-327	71	377	figures	figure	NOUN
admet-327	71	378	3	3	NUM
admet-327	71	379	and	and	CCONJ
admet-327	71	380	4	4	NUM
admet-327	71	381	.	.	X
admet-327	72	1	in	in	ADP
admet-327	72	2	the	the	DET
admet-327	72	3	latter	latter	ADJ
admet-327	72	4	cases	case	NOUN
admet-327	72	5	,	,	PUNCT
admet-327	72	6	even	even	ADV
admet-327	72	7	though	though	SCONJ
admet-327	72	8	the	the	DET
admet-327	72	9	aminoacid	aminoacid	NOUN
admet-327	72	10	sequences	sequence	NOUN
admet-327	72	11	and	and	CCONJ
admet-327	72	12	the	the	DET
admet-327	72	13	structures	structure	NOUN
admet-327	72	14	are	be	AUX
admet-327	72	15	identical	identical	ADJ
admet-327	72	16	,	,	PUNCT
admet-327	72	17	different	different	ADJ
admet-327	72	18	ligand	ligand	ADJ
admet-327	72	19	orientations	orientation	NOUN
admet-327	72	20	were	be	AUX
admet-327	72	21	observed	observe	VERB
admet-327	72	22	.	.	PUNCT
admet-327	73	1	2c95	2c95	NUM
admet-327	73	2	2c9y	2c9y	NUM
admet-327	73	3	2bwj	2bwj	NUM
admet-327	73	4	figure	figure	NOUN
admet-327	73	5	1	1	NUM
admet-327	73	6	.	.	PUNCT
admet-327	74	1	human	human	ADJ
admet-327	74	2	aks	ak	NOUN
admet-327	74	3	docked	dock	VERB
admet-327	74	4	with	with	ADP
admet-327	74	5	2,4	2,4	NUM
admet-327	74	6	-	-	PUNCT
admet-327	74	7	thiazolidinedione	thiazolidinedione	ADJ
admet-327	74	8	.	.	PUNCT
admet-327	75	1	2c95	2c95	NUM
admet-327	75	2	-	-	PUNCT
admet-327	75	3	ak1	ak1	NOUN
admet-327	75	4	;	;	PUNCT
admet-327	75	5	2c9y	2c9y	X
admet-327	75	6	-	-	PUNCT
admet-327	75	7	ak2	ak2	NOUN
admet-327	75	8	;	;	PUNCT
admet-327	75	9	2bwj	2bwj	NUM
admet-327	75	10	-	-	PUNCT
admet-327	75	11	ak5	ak5	ADJ
admet-327	75	12	code	code	NOUN
admet-327	75	13	color	color	NOUN
admet-327	75	14	for	for	ADP
admet-327	75	15	interactions	interaction	NOUN
admet-327	75	16	:	:	PUNCT
admet-327	75	17	in	in	ADP
admet-327	75	18	green	green	NOUN
admet-327	75	19	are	be	AUX
admet-327	75	20	shown	show	VERB
admet-327	75	21	conventional	conventional	ADJ
admet-327	75	22	hydrogen	hydrogen	NOUN
admet-327	75	23	bonds	bond	NOUN
admet-327	75	24	;	;	PUNCT
admet-327	75	25	yellow	yellow	ADJ
admet-327	75	26	–	–	PUNCT
admet-327	75	27	carbon	carbon	NOUN
admet-327	75	28	hydrogen	hydrogen	NOUN
admet-327	75	29	bonds	bond	NOUN
admet-327	75	30	;	;	PUNCT
admet-327	75	31	red	red	ADJ
admet-327	75	32	–	–	PUNCT
admet-327	75	33	unfavorable	unfavorable	ADJ
admet-327	75	34	bump	bump	VERB
admet-327	75	35	2c95	2c95	NUM
admet-327	75	36	2c9y	2c9y	NOUN
admet-327	75	37	2bwj	2bwj	NUM
admet-327	75	38	figure	figure	NOUN
admet-327	75	39	2	2	NUM
admet-327	75	40	.	.	NOUN
admet-327	75	41	interaction	interaction	NOUN
admet-327	75	42	2,4	2,4	NUM
admet-327	75	43	-	-	PUNCT
admet-327	75	44	thiazolidinedione	thiazolidinedione	NOUN
admet-327	75	45	with	with	ADP
admet-327	75	46	of	of	ADP
admet-327	75	47	human	human	ADJ
admet-327	75	48	aks	ak	NOUN
admet-327	75	49	3hpq	3hpq	PROPN
admet-327	75	50	1ank	1ank	PROPN
admet-327	75	51	2rgx	2rgx	PROPN
admet-327	75	52	figure	figure	VERB
admet-327	75	53	3	3	NUM
admet-327	75	54	.	.	PUNCT
admet-327	75	55	interaction	interaction	NOUN
admet-327	75	56	2,4	2,4	NUM
admet-327	75	57	-	-	PUNCT
admet-327	75	58	thiazolidinedione	thiazolidinedione	NOUN
admet-327	75	59	with	with	ADP
admet-327	75	60	of	of	ADP
admet-327	75	61	aks	ak	NOUN
admet-327	75	62	from	from	ADP
admet-327	75	63	gram	gram	NOUN
admet-327	75	64	-	-	PUNCT
admet-327	75	65	negative	negative	ADJ
admet-327	75	66	microorganisms	microorganism	NOUN
admet-327	75	67	mihaela	mihaela	PROPN
admet-327	75	68	i.	i.	PROPN
admet-327	75	69	ionescu	ionescu	PROPN
admet-327	75	70	admet	admet	PROPN
admet-327	75	71	&	&	CCONJ
admet-327	75	72	dmpk	dmpk	PROPN
admet-327	75	73	5(1	5(1	NUM
admet-327	75	74	)	)	PUNCT
admet-327	75	75	(	(	PUNCT
admet-327	75	76	2017	2017	NUM
admet-327	75	77	)	)	PUNCT
admet-327	75	78	47	47	NUM
admet-327	75	79	-	-	SYM
admet-327	75	80	56	56	NUM
admet-327	75	81	52	52	NUM
admet-327	75	82	3hpq	3hpq	PROPN
admet-327	75	83	1ank	1ank	NUM
admet-327	75	84	2rgx	2rgx	PROPN
admet-327	75	85	figure	figure	VERB
admet-327	75	86	4	4	NUM
admet-327	75	87	.	.	NOUN
admet-327	75	88	aks	ak	NOUN
admet-327	75	89	from	from	ADP
admet-327	75	90	gram	gram	NOUN
admet-327	75	91	-	-	PUNCT
admet-327	75	92	negative	negative	ADJ
admet-327	75	93	microorganisms	microorganism	NOUN
admet-327	75	94	docked	dock	VERB
admet-327	75	95	with	with	ADP
admet-327	75	96	2,4	2,4	NUM
admet-327	75	97	-	-	PUNCT
admet-327	75	98	thiazolidinedione	thiazolidinedione	ADJ
admet-327	75	99	.	.	PUNCT
admet-327	76	1	3hpq	3hpq	PROPN
admet-327	76	2	-	-	PUNCT
admet-327	76	3	e.	e.	PROPN
admet-327	76	4	coli	coli	NOUN
admet-327	76	5	;	;	PUNCT
admet-327	76	6	1anke	1anke	NUM
admet-327	76	7	.	.	X
admet-327	76	8	coli	coli	NOUN
admet-327	76	9	;	;	PUNCT
admet-327	77	1	2rgxa	2rgxa	NUM
admet-327	77	2	.	.	PUNCT
admet-327	77	3	aeolicus	aeolicus	PROPN
admet-327	77	4	.	.	PUNCT
admet-327	78	1	code	code	NOUN
admet-327	78	2	color	color	NOUN
admet-327	78	3	for	for	ADP
admet-327	78	4	interactions	interaction	NOUN
admet-327	78	5	:	:	PUNCT
admet-327	78	6	in	in	ADP
admet-327	78	7	green	green	NOUN
admet-327	78	8	are	be	AUX
admet-327	78	9	shown	show	VERB
admet-327	78	10	conventional	conventional	ADJ
admet-327	78	11	hydrogen	hydrogen	NOUN
admet-327	78	12	bonds	bond	NOUN
admet-327	78	13	;	;	PUNCT
admet-327	78	14	yellow	yellow	ADJ
admet-327	78	15	–	–	PUNCT
admet-327	78	16	carbon	carbon	NOUN
admet-327	78	17	hydrogen	hydrogen	NOUN
admet-327	78	18	bonds	bond	NOUN
admet-327	78	19	;	;	PUNCT
admet-327	78	20	orange	orange	ADJ
admet-327	78	21	–	–	PUNCT
admet-327	78	22	sulfur	sulfur	NOUN
admet-327	78	23	-	-	PUNCT
admet-327	78	24	x	x	NOUN
admet-327	78	25	;	;	PUNCT
admet-327	78	26	red	red	ADJ
admet-327	78	27	–	–	PUNCT
admet-327	78	28	unfavorable	unfavorable	ADJ
admet-327	78	29	acceptor	acceptor	NOUN
admet-327	78	30	-	-	PUNCT
admet-327	78	31	acceptor	acceptor	NOUN
admet-327	78	32	one	one	NUM
admet-327	78	33	explanation	explanation	NOUN
admet-327	78	34	could	could	AUX
admet-327	78	35	reside	reside	VERB
admet-327	78	36	on	on	ADP
admet-327	78	37	the	the	DET
admet-327	78	38	fact	fact	NOUN
admet-327	78	39	that	that	SCONJ
admet-327	78	40	the	the	DET
admet-327	78	41	two	two	NUM
admet-327	78	42	enzymes	enzyme	NOUN
admet-327	78	43	being	be	AUX
admet-327	78	44	co	co	VERB
admet-327	78	45	-	-	VERB
admet-327	78	46	crystallized	crystallize	VERB
admet-327	78	47	with	with	ADP
admet-327	78	48	different	different	ADJ
admet-327	78	49	substrate	substrate	NOUN
admet-327	78	50	analogs	analog	NOUN
admet-327	78	51	(	(	PUNCT
admet-327	78	52	table	table	NOUN
admet-327	78	53	1	1	NUM
admet-327	78	54	)	)	PUNCT
admet-327	78	55	.	.	PUNCT
admet-327	79	1	it	it	PRON
admet-327	79	2	is	be	AUX
admet-327	79	3	well	well	ADV
admet-327	79	4	known	know	VERB
admet-327	79	5	that	that	SCONJ
admet-327	79	6	ak	ak	PROPN
admet-327	79	7	is	be	AUX
admet-327	79	8	a	a	DET
admet-327	79	9	flexible	flexible	ADJ
admet-327	79	10	enzyme	enzyme	NOUN
admet-327	79	11	,	,	PUNCT
admet-327	79	12	the	the	DET
admet-327	79	13	lid	lid	NOUN
admet-327	79	14	domain	domain	NOUN
admet-327	79	15	and	and	CCONJ
admet-327	79	16	nmp	nmp	NOUN
admet-327	79	17	-	-	PUNCT
admet-327	79	18	binding	bind	VERB
admet-327	79	19	domain	domain	NOUN
admet-327	79	20	being	be	AUX
admet-327	79	21	highly	highly	ADV
admet-327	79	22	dynamic	dynamic	ADJ
admet-327	79	23	.	.	PUNCT
admet-327	80	1	therefore	therefore	ADV
admet-327	80	2	,	,	PUNCT
admet-327	80	3	the	the	DET
admet-327	80	4	transition	transition	NOUN
admet-327	80	5	between	between	ADP
admet-327	80	6	open	open	ADJ
admet-327	80	7	and	and	CCONJ
admet-327	80	8	closed	closed	ADJ
admet-327	80	9	states	state	NOUN
admet-327	80	10	is	be	AUX
admet-327	80	11	characterized	characterize	VERB
admet-327	80	12	by	by	ADP
admet-327	80	13	important	important	ADJ
admet-327	80	14	conformational	conformational	ADJ
admet-327	80	15	fluctuations	fluctuation	NOUN
admet-327	80	16	(	(	PUNCT
admet-327	80	17	dynamics	dynamic	NOUN
admet-327	80	18	)	)	PUNCT
admet-327	80	19	.	.	PUNCT
admet-327	81	1	studies	study	NOUN
admet-327	81	2	performed	perform	VERB
admet-327	81	3	with	with	ADP
admet-327	81	4	ak	ak	PROPN
admet-327	81	5	mutated	mutate	VERB
admet-327	81	6	in	in	ADP
admet-327	81	7	the	the	DET
admet-327	81	8	residues	residue	NOUN
admet-327	81	9	which	which	PRON
admet-327	81	10	do	do	AUX
admet-327	81	11	not	not	PART
admet-327	81	12	alter	alter	VERB
admet-327	81	13	its	its	PRON
admet-327	81	14	structure	structure	NOUN
admet-327	81	15	,	,	PUNCT
admet-327	81	16	demonstrated	demonstrate	VERB
admet-327	81	17	that	that	SCONJ
admet-327	81	18	the	the	DET
admet-327	81	19	binding	bind	VERB
admet-327	81	20	interactions	interaction	NOUN
admet-327	81	21	of	of	ADP
admet-327	81	22	different	different	ADJ
admet-327	81	23	ligands	ligand	NOUN
admet-327	81	24	affect	affect	VERB
admet-327	81	25	the	the	DET
admet-327	81	26	dynamics	dynamic	NOUN
admet-327	81	27	of	of	ADP
admet-327	81	28	ak	ak	PROPN
admet-327	81	29	,	,	PUNCT
admet-327	81	30	without	without	ADP
admet-327	81	31	accompanying	accompany	VERB
admet-327	81	32	structural	structural	ADJ
admet-327	81	33	changes	change	NOUN
admet-327	81	34	of	of	ADP
admet-327	81	35	the	the	DET
admet-327	81	36	enzyme	enzyme	NOUN
admet-327	81	37	[	[	NOUN
admet-327	81	38	23,27,28	23,27,28	NUM
admet-327	81	39	]	]	PUNCT
admet-327	81	40	.	.	PUNCT
admet-327	82	1	a.	a.	PROPN
admet-327	82	2	aeolicus	aeolicus	PROPN
admet-327	82	3	’s	’s	PROPN
admet-327	82	4	ak	ak	PROPN
admet-327	82	5	(	(	PUNCT
admet-327	82	6	2rgx	2rgx	PROPN
admet-327	82	7	)	)	PUNCT
admet-327	82	8	shows	show	VERB
admet-327	82	9	particularly	particularly	ADV
admet-327	82	10	comparable	comparable	ADJ
admet-327	82	11	docking	docking	NOUN
admet-327	82	12	with	with	ADP
admet-327	82	13	s.	s.	PROPN
admet-327	82	14	pneumoniae	pneumoniae	PROPN
admet-327	82	15	(	(	PUNCT
admet-327	82	16	4w5j	4w5j	ADJ
admet-327	82	17	)	)	PUNCT
admet-327	82	18	and	and	CCONJ
admet-327	82	19	m.	m.	NOUN
admet-327	82	20	tuberculosis	tuberculosis	NOUN
admet-327	82	21	(	(	PUNCT
admet-327	82	22	2cdn	2cdn	NUM
admet-327	82	23	)	)	PUNCT
admet-327	82	24	counterparts	counterpart	NOUN
admet-327	82	25	.	.	PUNCT
admet-327	83	1	the	the	DET
admet-327	83	2	exception	exception	NOUN
admet-327	83	3	is	be	AUX
admet-327	83	4	phe35	phe35	PROPN
admet-327	83	5	residue	residue	NOUN
admet-327	83	6	which	which	PRON
admet-327	83	7	is	be	AUX
admet-327	83	8	not	not	PART
admet-327	83	9	present	present	ADJ
admet-327	83	10	in	in	ADP
admet-327	83	11	gram	gram	NOUN
admet-327	83	12	-	-	PUNCT
admet-327	83	13	negative	negative	ADJ
admet-327	83	14	aks	ak	NOUN
admet-327	83	15	.	.	PUNCT
admet-327	84	1	on	on	ADP
admet-327	84	2	the	the	DET
admet-327	84	3	contrary	contrary	NOUN
admet-327	84	4	,	,	PUNCT
admet-327	84	5	2rgk	2rgk	PROPN
admet-327	84	6	binds	bind	VERB
admet-327	84	7	the	the	DET
admet-327	84	8	sulfur	sulfur	NOUN
admet-327	84	9	from	from	ADP
admet-327	84	10	2,4	2,4	NUM
admet-327	84	11	-	-	PUNCT
admet-327	84	12	thiazolidinedione	thiazolidinedione	ADJ
admet-327	84	13	structure	structure	NOUN
admet-327	84	14	to	to	ADP
admet-327	84	15	thr31	thr31	ADJ
admet-327	84	16	residue	residue	NOUN
admet-327	84	17	.	.	PUNCT
admet-327	85	1	moreover	moreover	ADV
admet-327	85	2	,	,	PUNCT
admet-327	85	3	glutamine	glutamine	NOUN
admet-327	85	4	,	,	PUNCT
admet-327	85	5	a	a	DET
admet-327	85	6	polar	polar	ADJ
admet-327	85	7	residue	residue	NOUN
admet-327	85	8	strictly	strictly	ADV
admet-327	85	9	conserved	conserve	VERB
admet-327	85	10	in	in	ADP
admet-327	85	11	aks	ak	NOUN
admet-327	85	12	–	–	PUNCT
admet-327	85	13	the	the	DET
admet-327	85	14	last	last	ADJ
admet-327	85	15	residue	residue	NOUN
admet-327	85	16	of	of	ADP
admet-327	85	17	the	the	DET
admet-327	85	18	consensus	consensus	NOUN
admet-327	85	19	sequence	sequence	NOUN
admet-327	85	20	motif	motif	NOUN
admet-327	86	1	[	[	X
admet-327	86	2	livmfywca	livmfywca	NOUN
admet-327	86	3	]	]	X
admet-327	86	4	–	–	PUNCT
admet-327	86	5	[	[	X
admet-327	86	6	livmfyw	livmfyw	X
admet-327	86	7	]	]	X
admet-327	86	8	(	(	PUNCT
admet-327	86	9	2)–d	2)–d	NUM
admet-327	86	10	–	–	PUNCT
admet-327	86	11	g–[fy]–p	g–[fy]–p	NOUN
admet-327	86	12	–	–	PUNCT
admet-327	86	13	r	r	NOUN
admet-327	86	14	–	–	PUNCT
admet-327	86	15	x(3	x(3	NOUN
admet-327	86	16	)	)	PUNCT
admet-327	86	17	–	–	PUNCT
admet-327	87	1	[	[	X
admet-327	87	2	nq	nq	X
admet-327	87	3	]	]	PUNCT
admet-327	87	4	–	–	PUNCT
admet-327	87	5	promotes	promote	VERB
admet-327	87	6	hydrogen	hydrogen	NOUN
admet-327	87	7	bonds	bond	NOUN
admet-327	87	8	with	with	ADP
admet-327	87	9	o2	o2	PROPN
admet-327	87	10	/	/	SYM
admet-327	87	11	o3	o3	PROPN
admet-327	87	12	in	in	ADP
admet-327	87	13	a.	a.	PROPN
admet-327	87	14	aeolicus	aeolicus	PROPN
admet-327	87	15	,	,	PUNCT
admet-327	87	16	e.	e.	PROPN
admet-327	87	17	coli	coli	PROPN
admet-327	87	18	(	(	PUNCT
admet-327	87	19	1ank	1ank	NUM
admet-327	87	20	)	)	PUNCT
admet-327	87	21	,	,	PUNCT
admet-327	87	22	ak1	ak1	PROPN
admet-327	87	23	,	,	PUNCT
admet-327	87	24	m.	m.	NOUN
admet-327	87	25	tuberculosis	tuberculosis	NOUN
admet-327	87	26	,	,	PUNCT
admet-327	87	27	and	and	CCONJ
admet-327	87	28	gram	gram	NOUN
admet-327	87	29	-	-	PUNCT
admet-327	87	30	positive	positive	ADJ
admet-327	87	31	aks	ak	NOUN
admet-327	87	32	.	.	PUNCT
admet-327	88	1	on	on	ADP
admet-327	88	2	these	these	DET
admet-327	88	3	six	six	NUM
admet-327	88	4	aks	ak	NOUN
admet-327	88	5	,	,	PUNCT
admet-327	88	6	sulfur	sulfur	NOUN
admet-327	88	7	atom	atom	NOUN
admet-327	88	8	contributes	contribute	VERB
admet-327	88	9	to	to	ADP
admet-327	88	10	protein	protein	NOUN
admet-327	88	11	-	-	PUNCT
admet-327	88	12	ligand	ligand	ADJ
admet-327	88	13	complex	complex	ADJ
admet-327	88	14	stabilization	stabilization	NOUN
admet-327	88	15	also	also	ADV
admet-327	88	16	.	.	PUNCT
admet-327	89	1	contrary	contrary	ADJ
admet-327	89	2	to	to	ADP
admet-327	89	3	aks	ak	NOUN
admet-327	89	4	of	of	ADP
admet-327	89	5	gram	gram	NOUN
admet-327	89	6	-	-	PUNCT
admet-327	89	7	positive	positive	ADJ
admet-327	89	8	and	and	CCONJ
admet-327	89	9	acid	acid	ADJ
admet-327	89	10	fast	fast	ADJ
admet-327	89	11	bacteria	bacteria	NOUN
admet-327	89	12	where	where	SCONJ
admet-327	89	13	pi	pi	NOUN
admet-327	89	14	-	-	PUNCT
admet-327	89	15	sulfur	sulfur	NOUN
admet-327	89	16	interactions	interaction	NOUN
admet-327	89	17	were	be	AUX
admet-327	89	18	observed	observe	VERB
admet-327	89	19	,	,	PUNCT
admet-327	89	20	hydrogen	hydrogen	NOUN
admet-327	89	21	bonds	bond	NOUN
admet-327	89	22	were	be	AUX
admet-327	89	23	noticed	notice	VERB
admet-327	89	24	for	for	ADP
admet-327	89	25	the	the	DET
admet-327	89	26	rest	rest	NOUN
admet-327	89	27	.	.	PUNCT
admet-327	90	1	regarding	regard	VERB
admet-327	90	2	1ank	1ank	NUM
admet-327	90	3	and	and	CCONJ
admet-327	90	4	ak1	ak1	NOUN
admet-327	90	5	,	,	PUNCT
admet-327	90	6	the	the	DET
admet-327	90	7	valine	valine	NOUN
admet-327	90	8	residue	residue	NOUN
admet-327	90	9	val59	val59	NOUN
admet-327	90	10	,	,	PUNCT
admet-327	90	11	respectively	respectively	ADV
admet-327	90	12	val67	val67	ADJ
admet-327	90	13	,	,	PUNCT
admet-327	90	14	strictly	strictly	ADV
admet-327	90	15	conserved	conserve	VERB
admet-327	90	16	in	in	ADP
admet-327	90	17	aks	ak	NOUN
admet-327	90	18	,	,	PUNCT
admet-327	90	19	participates	participate	VERB
admet-327	90	20	in	in	ADP
admet-327	90	21	hydrogen	hydrogen	NOUN
admet-327	90	22	bonding	bonding	NOUN
admet-327	90	23	with	with	ADP
admet-327	90	24	sulfur	sulfur	NOUN
admet-327	90	25	atom	atom	NOUN
admet-327	90	26	.	.	PUNCT
admet-327	91	1	admet	admet	PROPN
admet-327	91	2	&	&	CCONJ
admet-327	91	3	dmpk	dmpk	PROPN
admet-327	91	4	5(1	5(1	NUM
admet-327	91	5	)	)	PUNCT
admet-327	91	6	(	(	PUNCT
admet-327	91	7	2017	2017	NUM
admet-327	91	8	)	)	PUNCT
admet-327	91	9	47	47	NUM
admet-327	91	10	-	-	SYM
admet-327	91	11	56	56	NUM
admet-327	91	12	adenylate	adenylate	ADJ
admet-327	91	13	kinase	kinase	NOUN
admet-327	91	14	inhibition	inhibition	NOUN
admet-327	91	15	by	by	ADP
admet-327	91	16	2,4	2,4	NUM
admet-327	91	17	-	-	PUNCT
admet-327	91	18	thiazolidinedione	thiazolidinedione	ADJ
admet-327	91	19	doi	doi	NOUN
admet-327	91	20	:	:	PUNCT
admet-327	91	21	10.5599	10.5599	NUM
admet-327	91	22	/	/	SYM
admet-327	91	23	admet.5.1.327	admet.5.1.327	PROPN
admet-327	91	24	53	53	NUM
admet-327	91	25	4w5j	4w5j	NOUN
admet-327	91	26	1zip	1zip	NUM
admet-327	91	27	2cdn	2cdn	NUM
admet-327	91	28	figure	figure	NOUN
admet-327	91	29	5	5	NUM
admet-327	91	30	.	.	PUNCT
admet-327	91	31	interaction	interaction	NOUN
admet-327	91	32	2,4	2,4	NUM
admet-327	91	33	-	-	PUNCT
admet-327	91	34	thiazolidinedione	thiazolidinedione	NOUN
admet-327	91	35	with	with	ADP
admet-327	91	36	of	of	ADP
admet-327	91	37	aks	ak	NOUN
admet-327	91	38	from	from	ADP
admet-327	91	39	gram	gram	NOUN
admet-327	91	40	-	-	PUNCT
admet-327	91	41	positive	positive	ADJ
admet-327	91	42	and	and	CCONJ
admet-327	91	43	acid	acid	ADJ
admet-327	91	44	fast	fast	ADJ
admet-327	91	45	microorganisms	microorganism	NOUN
admet-327	91	46	4w5j	4w5j	NOUN
admet-327	92	1	1zip	1zip	NUM
admet-327	92	2	2cdn	2cdn	NUM
admet-327	92	3	figure	figure	NOUN
admet-327	92	4	6	6	NUM
admet-327	92	5	.	.	PUNCT
admet-327	92	6	aks	ak	NOUN
admet-327	92	7	from	from	ADP
admet-327	92	8	gram	gram	NOUN
admet-327	92	9	-	-	PUNCT
admet-327	92	10	positive	positive	ADJ
admet-327	92	11	and	and	CCONJ
admet-327	92	12	acid	acid	ADJ
admet-327	92	13	fast	fast	ADJ
admet-327	92	14	microorganisms	microorganism	NOUN
admet-327	92	15	docked	dock	VERB
admet-327	92	16	with	with	ADP
admet-327	92	17	2,4	2,4	NUM
admet-327	92	18	-	-	PUNCT
admet-327	92	19	thiazolidinedione	thiazolidinedione	NOUN
admet-327	92	20	.	.	PUNCT
admet-327	93	1	4w5js	4w5js	NUM
admet-327	93	2	.	.	PUNCT
admet-327	94	1	pneumoniae	pneumoniae	ADJ
admet-327	94	2	;	;	PUNCT
admet-327	94	3	1zipb	1zipb	NUM
admet-327	94	4	.	.	NOUN
admet-327	94	5	stearothermophilus	stearothermophilus	PROPN
admet-327	94	6	;	;	PUNCT
admet-327	94	7	2cdnm	2cdnm	NUM
admet-327	94	8	.	.	X
admet-327	95	1	tuberculosis	tuberculosis	NOUN
admet-327	95	2	.	.	PUNCT
admet-327	96	1	code	code	NOUN
admet-327	96	2	color	color	NOUN
admet-327	96	3	for	for	ADP
admet-327	96	4	interactions	interaction	NOUN
admet-327	96	5	:	:	PUNCT
admet-327	96	6	in	in	ADP
admet-327	96	7	green	green	NOUN
admet-327	96	8	are	be	AUX
admet-327	96	9	shown	show	VERB
admet-327	96	10	conventional	conventional	ADJ
admet-327	96	11	hydrogen	hydrogen	NOUN
admet-327	96	12	bonds	bond	NOUN
admet-327	96	13	;	;	PUNCT
admet-327	96	14	yellow	yellow	ADJ
admet-327	96	15	–	–	PUNCT
admet-327	96	16	carbon	carbon	NOUN
admet-327	96	17	hydrogen	hydrogen	NOUN
admet-327	96	18	bonds	bond	NOUN
admet-327	96	19	;	;	PUNCT
admet-327	96	20	orange	orange	ADJ
admet-327	96	21	–	–	PUNCT
admet-327	96	22	pi	pi	NOUN
admet-327	96	23	-	-	PUNCT
admet-327	96	24	sulfur	sulfur	NOUN
admet-327	96	25	in	in	ADP
admet-327	96	26	gram	gram	NOUN
admet-327	96	27	-	-	PUNCT
admet-327	96	28	negative	negative	ADJ
admet-327	96	29	microorganisms	microorganism	NOUN
admet-327	96	30	,	,	PUNCT
admet-327	96	31	the	the	DET
admet-327	96	32	ligand	ligand	ADJ
admet-327	96	33	2,4	2,4	NUM
admet-327	96	34	-	-	PUNCT
admet-327	96	35	thiazolidinedione	thiazolidinedione	NOUN
admet-327	96	36	binds	bind	VERB
admet-327	96	37	different	different	ADJ
admet-327	96	38	residues	residue	NOUN
admet-327	96	39	.	.	PUNCT
admet-327	97	1	looking	look	VERB
admet-327	97	2	at	at	ADP
admet-327	97	3	e.	e.	PROPN
admet-327	97	4	coli	coli	PROPN
admet-327	97	5	’s	’s	PART
admet-327	97	6	aks	ak	NOUN
admet-327	97	7	,	,	PUNCT
admet-327	97	8	we	we	PRON
admet-327	97	9	noticed	notice	VERB
admet-327	97	10	that	that	SCONJ
admet-327	97	11	gly85	gly85	NOUN
admet-327	97	12	,	,	PUNCT
admet-327	97	13	another	another	DET
admet-327	97	14	residue	residue	NOUN
admet-327	97	15	strictly	strictly	ADV
admet-327	97	16	conserved	conserve	VERB
admet-327	97	17	from	from	ADP
admet-327	97	18	the	the	DET
admet-327	97	19	consensus	consensus	NOUN
admet-327	97	20	sequence	sequence	NOUN
admet-327	97	21	motif	motif	NOUN
admet-327	97	22	,	,	PUNCT
admet-327	97	23	promotes	promote	VERB
admet-327	97	24	a	a	DET
admet-327	97	25	hydrogen	hydrogen	NOUN
admet-327	97	26	bonding	bonding	NOUN
admet-327	97	27	with	with	ADP
admet-327	97	28	the	the	DET
admet-327	97	29	sulfur	sulfur	NOUN
admet-327	97	30	in	in	ADP
admet-327	97	31	the	the	DET
admet-327	97	32	instance	instance	NOUN
admet-327	97	33	of	of	ADP
admet-327	97	34	3hpq	3hpq	NUM
admet-327	97	35	,	,	PUNCT
admet-327	97	36	but	but	CCONJ
admet-327	97	37	failed	fail	VERB
admet-327	97	38	to	to	PART
admet-327	97	39	establish	establish	VERB
admet-327	97	40	a	a	DET
admet-327	97	41	valid	valid	ADJ
admet-327	97	42	interaction	interaction	NOUN
admet-327	97	43	in	in	ADP
admet-327	97	44	1ank	1ank	NUM
admet-327	97	45	.	.	PUNCT
admet-327	98	1	on	on	ADP
admet-327	98	2	the	the	DET
admet-327	98	3	contrary	contrary	NOUN
admet-327	98	4	,	,	PUNCT
admet-327	98	5	in	in	ADP
admet-327	98	6	human	human	ADJ
admet-327	98	7	ak2	ak2	NOUN
admet-327	98	8	,	,	PUNCT
admet-327	98	9	this	this	DET
admet-327	98	10	residue	residue	NOUN
admet-327	98	11	(	(	PUNCT
admet-327	98	12	gly100	gly100	NOUN
admet-327	98	13	)	)	PUNCT
admet-327	98	14	interacts	interact	VERB
admet-327	98	15	with	with	ADP
admet-327	98	16	the	the	DET
admet-327	98	17	o2	o2	ADJ
admet-327	98	18	atom	atom	NOUN
admet-327	98	19	from	from	ADP
admet-327	98	20	the	the	DET
admet-327	98	21	2,4	2,4	NUM
admet-327	98	22	-	-	PUNCT
admet-327	98	23	thiazolidinedione	thiazolidinedione	NUM
admet-327	98	24	structure	structure	NOUN
admet-327	98	25	.	.	PUNCT
admet-327	99	1	as	as	SCONJ
admet-327	99	2	it	it	PRON
admet-327	99	3	is	be	AUX
admet-327	99	4	demonstrated	demonstrate	VERB
admet-327	99	5	in	in	ADP
admet-327	99	6	the	the	DET
admet-327	99	7	figures	figure	NOUN
admet-327	99	8	5	5	NUM
admet-327	99	9	and	and	CCONJ
admet-327	99	10	6	6	NUM
admet-327	99	11	and	and	CCONJ
admet-327	99	12	in	in	ADP
admet-327	99	13	multiple	multiple	ADJ
admet-327	99	14	sequence	sequence	NOUN
admet-327	99	15	alignment	alignment	NOUN
admet-327	99	16	(	(	PUNCT
admet-327	99	17	figure	figure	NOUN
admet-327	99	18	7	7	NUM
admet-327	99	19	)	)	PUNCT
admet-327	99	20	,	,	PUNCT
admet-327	99	21	aks	ak	NOUN
admet-327	99	22	from	from	ADP
admet-327	99	23	gram	gram	NOUN
admet-327	99	24	-	-	PUNCT
admet-327	99	25	positive	positive	ADJ
admet-327	99	26	and	and	CCONJ
admet-327	99	27	acid	acid	ADJ
admet-327	99	28	fast	fast	ADJ
admet-327	99	29	microorganisms	microorganism	NOUN
admet-327	99	30	,	,	PUNCT
admet-327	99	31	bind	bind	VERB
admet-327	99	32	almost	almost	ADV
admet-327	99	33	in	in	ADP
admet-327	99	34	the	the	DET
admet-327	99	35	same	same	ADJ
admet-327	99	36	manner	manner	NOUN
admet-327	99	37	the	the	DET
admet-327	99	38	residues	residue	NOUN
admet-327	99	39	involved	involve	VERB
admet-327	99	40	in	in	ADP
admet-327	99	41	ampbinding	ampbinde	VERB
admet-327	99	42	(	(	PUNCT
admet-327	99	43	thr31	thr31	ADJ
admet-327	99	44	,	,	PUNCT
admet-327	99	45	gln93	gln93	NOUN
admet-327	99	46	,	,	PUNCT
admet-327	99	47	and	and	CCONJ
admet-327	99	48	phe35	phe35	PROPN
admet-327	99	49	)	)	PUNCT
admet-327	99	50	,	,	PUNCT
admet-327	99	51	a	a	DET
admet-327	99	52	notable	notable	ADJ
admet-327	99	53	difference	difference	NOUN
admet-327	99	54	is	be	AUX
admet-327	99	55	for	for	SCONJ
admet-327	99	56	ak	ak	PROPN
admet-327	99	57	from	from	ADP
admet-327	99	58	b.	b.	PROPN
admet-327	99	59	stearothermophilus	stearothermophilus	PROPN
admet-327	99	60	in	in	ADP
admet-327	99	61	this	this	DET
admet-327	99	62	latter	latter	ADJ
admet-327	99	63	instance	instance	NOUN
admet-327	99	64	,	,	PUNCT
admet-327	99	65	the	the	DET
admet-327	99	66	smallest	small	ADJ
admet-327	99	67	binding	bind	VERB
admet-327	99	68	affinity	affinity	NOUN
admet-327	99	69	is	be	AUX
admet-327	99	70	noticed	notice	VERB
admet-327	99	71	–	–	PUNCT
admet-327	99	72	ki	ki	X
admet-327	99	73	=	=	PUNCT
admet-327	99	74	0.64	0.64	NUM
admet-327	99	75	mm	mm	NOUN
admet-327	99	76	.	.	PUNCT
admet-327	100	1	one	one	PRON
admet-327	100	2	can	can	AUX
admet-327	100	3	speculate	speculate	VERB
admet-327	100	4	other	other	ADJ
admet-327	100	5	gram	gram	NOUN
admet-327	100	6	-	-	PUNCT
admet-327	100	7	positive	positive	ADJ
admet-327	100	8	pathogens	pathogen	NOUN
admet-327	100	9	aks	ak	NOUN
admet-327	100	10	’	'	PUNCT
admet-327	100	11	have	have	VERB
admet-327	100	12	the	the	DET
admet-327	100	13	same	same	ADJ
admet-327	100	14	inhibition	inhibition	NOUN
admet-327	100	15	pattern	pattern	NOUN
admet-327	100	16	.	.	PUNCT
admet-327	101	1	aks	ak	NOUN
admet-327	101	2	of	of	ADP
admet-327	101	3	human	human	ADJ
admet-327	101	4	origin	origin	NOUN
admet-327	101	5	display	display	VERB
admet-327	101	6	unfavorable	unfavorable	ADJ
admet-327	101	7	interactions	interaction	NOUN
admet-327	101	8	,	,	PUNCT
admet-327	101	9	the	the	DET
admet-327	101	10	binding	bind	VERB
admet-327	101	11	affinity	affinity	NOUN
admet-327	101	12	fluctuating	fluctuate	VERB
admet-327	101	13	among	among	ADP
admet-327	101	14	0.84	0.84	NUM
admet-327	101	15	mm	mm	NOUN
admet-327	101	16	mihaela	mihaela	PROPN
admet-327	101	17	i.	i.	PROPN
admet-327	101	18	ionescu	ionescu	PROPN
admet-327	101	19	admet	admet	PROPN
admet-327	101	20	&	&	CCONJ
admet-327	101	21	dmpk	dmpk	PROPN
admet-327	101	22	5(1	5(1	NUM
admet-327	101	23	)	)	PUNCT
admet-327	101	24	(	(	PUNCT
admet-327	101	25	2017	2017	NUM
admet-327	101	26	)	)	PUNCT
admet-327	101	27	47	47	NUM
admet-327	101	28	-	-	SYM
admet-327	101	29	56	56	NUM
admet-327	101	30	54	54	NUM
admet-327	101	31	and	and	CCONJ
admet-327	101	32	8.8	8.8	NUM
admet-327	101	33	mm	mm	NOUN
admet-327	101	34	.	.	PUNCT
admet-327	102	1	mitochondrial	mitochondrial	ADJ
admet-327	102	2	isoenzyme	isoenzyme	NOUN
admet-327	102	3	2	2	NUM
admet-327	102	4	of	of	ADP
admet-327	102	5	ak	ak	PROPN
admet-327	102	6	behaves	behave	NOUN
admet-327	102	7	in	in	ADP
admet-327	102	8	the	the	DET
admet-327	102	9	same	same	ADJ
admet-327	102	10	manner	manner	NOUN
admet-327	102	11	as	as	ADP
admet-327	102	12	one	one	NUM
admet-327	102	13	e.	e.	PROPN
admet-327	102	14	coli	coli	PROPN
admet-327	102	15	’s	’s	PART
admet-327	102	16	ak	ak	PROPN
admet-327	102	17	3hpq	3hpq	PROPN
admet-327	102	18	.	.	PUNCT
admet-327	103	1	as	as	SCONJ
admet-327	103	2	demonstrated	demonstrate	VERB
admet-327	103	3	in	in	ADP
admet-327	103	4	the	the	DET
admet-327	103	5	figure	figure	NOUN
admet-327	103	6	7	7	NUM
admet-327	103	7	,	,	PUNCT
admet-327	103	8	they	they	PRON
admet-327	103	9	bind	bind	VERB
admet-327	103	10	the	the	DET
admet-327	103	11	same	same	ADJ
admet-327	103	12	residues	residue	NOUN
admet-327	103	13	and	and	CCONJ
admet-327	103	14	have	have	VERB
admet-327	103	15	comparable	comparable	ADJ
admet-327	103	16	binding	binding	ADJ
admet-327	103	17	affinity	affinity	NOUN
admet-327	103	18	,	,	PUNCT
admet-327	103	19	ki	ki	PROPN
admet-327	103	20	=	=	PUNCT
admet-327	104	1	0.84	0.84	NUM
admet-327	104	2	mm	mm	NOUN
admet-327	104	3	and	and	CCONJ
admet-327	104	4	0.86	0.86	NUM
admet-327	104	5	mm	mm	NOUN
admet-327	104	6	(	(	PUNCT
admet-327	104	7	table	table	NOUN
admet-327	104	8	2	2	NUM
admet-327	104	9	)	)	PUNCT
admet-327	104	10	.	.	PUNCT
admet-327	105	1	on	on	ADP
admet-327	105	2	the	the	DET
admet-327	105	3	contrary	contrary	NOUN
admet-327	105	4	,	,	PUNCT
admet-327	105	5	even	even	ADV
admet-327	105	6	though	though	SCONJ
admet-327	105	7	ak2	ak2	NOUN
admet-327	105	8	has	have	VERB
admet-327	105	9	energy	energy	NOUN
admet-327	105	10	binding	bind	VERB
admet-327	105	11	and	and	CCONJ
admet-327	105	12	ki	ki	PROPN
admet-327	105	13	comparable	comparable	ADJ
admet-327	105	14	to	to	ADP
admet-327	105	15	gram	gram	NOUN
admet-327	105	16	-	-	PUNCT
admet-327	105	17	positive	positive	ADJ
admet-327	105	18	microorganisms	microorganism	NOUN
admet-327	105	19	,	,	PUNCT
admet-327	105	20	2,4	2,4	NUM
admet-327	105	21	-	-	PUNCT
admet-327	105	22	thiazolidinedione	thiazolidinedione	NOUN
admet-327	105	23	binds	bind	VERB
admet-327	105	24	amp	amp	NOUN
admet-327	105	25	-	-	PUNCT
admet-327	105	26	binding	bind	VERB
admet-327	105	27	pocket	pocket	NOUN
admet-327	105	28	and	and	CCONJ
admet-327	105	29	atp	atp	NOUN
admet-327	105	30	-	-	PUNCT
admet-327	105	31	binding	bind	VERB
admet-327	105	32	domain	domain	NOUN
admet-327	105	33	simultaneously	simultaneously	ADV
admet-327	105	34	.	.	PUNCT
admet-327	106	1	considering	consider	VERB
admet-327	106	2	these	these	DET
admet-327	106	3	different	different	ADJ
admet-327	106	4	binding	bind	VERB
admet-327	106	5	patterns	pattern	NOUN
admet-327	106	6	of	of	ADP
admet-327	106	7	human	human	ADJ
admet-327	106	8	aks	ak	NOUN
admet-327	106	9	the	the	DET
admet-327	106	10	selectivity	selectivity	NOUN
admet-327	106	11	of	of	ADP
admet-327	106	12	2,4thiazolidinedione	2,4thiazolidinedione	NUM
admet-327	106	13	is	be	AUX
admet-327	106	14	an	an	DET
admet-327	106	15	advantage	advantage	NOUN
admet-327	106	16	in	in	ADP
admet-327	106	17	the	the	DET
admet-327	106	18	context	context	NOUN
admet-327	106	19	of	of	ADP
admet-327	106	20	antimicrobial	antimicrobial	ADJ
admet-327	106	21	treatment	treatment	NOUN
admet-327	106	22	.	.	PUNCT
admet-327	107	1	multiple	multiple	ADJ
admet-327	107	2	sequence	sequence	NOUN
admet-327	107	3	alignment	alignment	NOUN
admet-327	107	4	primary	primary	ADJ
admet-327	107	5	structure	structure	NOUN
admet-327	107	6	offers	offer	VERB
admet-327	107	7	useful	useful	ADJ
admet-327	107	8	details	detail	NOUN
admet-327	107	9	;	;	PUNCT
admet-327	107	10	comparisons	comparison	NOUN
admet-327	107	11	of	of	ADP
admet-327	107	12	even	even	ADV
admet-327	107	13	small	small	ADJ
admet-327	107	14	identities	identity	NOUN
admet-327	107	15	could	could	AUX
admet-327	107	16	be	be	AUX
admet-327	107	17	exploited	exploit	VERB
admet-327	107	18	for	for	ADP
admet-327	107	19	finding	find	VERB
admet-327	107	20	interesting	interesting	ADJ
admet-327	107	21	patterns	pattern	NOUN
admet-327	107	22	.	.	PUNCT
admet-327	108	1	it	it	PRON
admet-327	108	2	would	would	AUX
admet-327	108	3	be	be	AUX
admet-327	108	4	of	of	ADP
admet-327	108	5	interest	interest	NOUN
admet-327	108	6	to	to	PART
admet-327	108	7	speculate	speculate	VERB
admet-327	108	8	that	that	SCONJ
admet-327	108	9	enzymes	enzyme	NOUN
admet-327	108	10	with	with	ADP
admet-327	108	11	similar	similar	ADJ
admet-327	108	12	primary	primary	ADJ
admet-327	108	13	structure	structure	NOUN
admet-327	108	14	,	,	PUNCT
admet-327	108	15	behave	behave	VERB
admet-327	108	16	the	the	DET
admet-327	108	17	same	same	ADJ
admet-327	108	18	with	with	ADP
admet-327	108	19	otherwise	otherwise	ADV
admet-327	108	20	well	well	ADV
admet-327	108	21	characterized	characterize	VERB
admet-327	108	22	enzyme	enzyme	NOUN
admet-327	108	23	.	.	PUNCT
admet-327	109	1	sometimes	sometimes	ADV
admet-327	109	2	,	,	PUNCT
admet-327	109	3	observing	observe	VERB
admet-327	109	4	minute	minute	ADJ
admet-327	109	5	details	detail	NOUN
admet-327	109	6	on	on	ADP
admet-327	109	7	primary	primary	ADJ
admet-327	109	8	structure	structure	NOUN
admet-327	109	9	has	have	VERB
admet-327	109	10	a	a	DET
admet-327	109	11	major	major	ADJ
admet-327	109	12	impact	impact	NOUN
admet-327	109	13	in	in	ADP
admet-327	109	14	decipher	decipher	ADJ
admet-327	109	15	intriguing	intriguing	ADJ
admet-327	109	16	mechanism	mechanism	NOUN
admet-327	109	17	of	of	ADP
admet-327	109	18	a	a	DET
admet-327	109	19	particular	particular	ADJ
admet-327	109	20	protein	protein	NOUN
admet-327	109	21	.	.	PUNCT
admet-327	110	1	the	the	DET
admet-327	110	2	ligand	ligand	NOUN
admet-327	110	3	chooses	choose	VERB
admet-327	110	4	for	for	ADP
admet-327	110	5	the	the	DET
admet-327	110	6	present	present	ADJ
admet-327	110	7	work	work	NOUN
admet-327	110	8	,	,	PUNCT
admet-327	110	9	2,4	2,4	NUM
admet-327	110	10	-	-	PUNCT
admet-327	110	11	thiazolidinedione	thiazolidinedione	NOUN
admet-327	110	12	,	,	PUNCT
admet-327	110	13	has	have	AUX
admet-327	110	14	proven	prove	VERB
admet-327	110	15	to	to	PART
admet-327	110	16	bind	bind	VERB
admet-327	110	17	important	important	ADJ
admet-327	110	18	residues	residue	NOUN
admet-327	110	19	involved	involve	VERB
admet-327	110	20	in	in	ADP
admet-327	110	21	amp	amp	NOUN
admet-327	110	22	-	-	PUNCT
admet-327	110	23	binding	bind	VERB
admet-327	110	24	.	.	PUNCT
admet-327	111	1	figure	figure	NOUN
admet-327	111	2	7	7	NUM
admet-327	111	3	.	.	PUNCT
admet-327	111	4	multiple	multiple	ADJ
admet-327	111	5	sequence	sequence	NOUN
admet-327	111	6	alignment	alignment	NOUN
admet-327	111	7	.	.	PUNCT
admet-327	112	1	in	in	ADP
admet-327	112	2	gray	gray	ADJ
admet-327	112	3	background	background	NOUN
admet-327	112	4	is	be	AUX
admet-327	112	5	marked	mark	VERB
admet-327	112	6	atp	atp	NOUN
admet-327	112	7	-	-	PUNCT
admet-327	112	8	binding	bind	VERB
admet-327	112	9	domain	domain	NOUN
admet-327	112	10	–	–	PUNCT
admet-327	112	11	the	the	DET
admet-327	112	12	walker	walker	NOUN
admet-327	112	13	a	a	DET
admet-327	112	14	motif	motif	NOUN
admet-327	112	15	gxxxxgkgt	gxxxxgkgt	X
admet-327	112	16	/	/	SYM
admet-327	112	17	s	s	PROPN
admet-327	112	18	;	;	PUNCT
admet-327	112	19	in	in	ADP
admet-327	112	20	blue	blue	ADJ
admet-327	112	21	background	background	NOUN
admet-327	112	22	are	be	AUX
admet-327	112	23	shown	show	VERB
admet-327	112	24	leucine	leucine	NOUN
admet-327	112	25	and	and	CCONJ
admet-327	112	26	valine	valine	NOUN
admet-327	112	27	residues	residue	NOUN
admet-327	112	28	,	,	PUNCT
admet-327	112	29	very	very	ADV
admet-327	112	30	well	well	ADV
admet-327	112	31	conserved	conserve	VERB
admet-327	112	32	in	in	ADP
admet-327	112	33	aks	ak	NOUN
admet-327	112	34	family	family	NOUN
admet-327	112	35	;	;	PUNCT
admet-327	112	36	in	in	ADP
admet-327	112	37	green	green	ADJ
admet-327	112	38	background	background	NOUN
admet-327	112	39	is	be	AUX
admet-327	112	40	highlighted	highlight	VERB
admet-327	112	41	the	the	DET
admet-327	112	42	consensus	consensus	NOUN
admet-327	112	43	sequence	sequence	NOUN
admet-327	113	1	[	[	X
admet-327	113	2	livmfywca	livmfywca	X
admet-327	113	3	]	]	X
admet-327	113	4	–	–	PUNCT
admet-327	113	5	[	[	X
admet-327	113	6	livmfyw	livmfyw	X
admet-327	113	7	]	]	X
admet-327	113	8	(	(	PUNCT
admet-327	113	9	2)–d	2)–d	NUM
admet-327	113	10	–	–	PUNCT
admet-327	113	11	g–[fy	g–[fy	VERB
admet-327	113	12	]	]	PUNCT
admet-327	113	13	–	–	PUNCT
admet-327	113	14	p	p	X
admet-327	113	15	–	–	PUNCT
admet-327	113	16	r	r	NOUN
admet-327	113	17	–	–	PUNCT
admet-327	113	18	x(3)–[nq	x(3)–[nq	NOUN
admet-327	113	19	]	]	PUNCT
admet-327	113	20	,	,	PUNCT
admet-327	113	21	were	be	AUX
admet-327	113	22	aspartic	aspartic	ADJ
admet-327	113	23	acid	acid	NOUN
admet-327	113	24	and	and	CCONJ
admet-327	113	25	arginine	arginine	NOUN
admet-327	113	26	,	,	PUNCT
admet-327	113	27	strictly	strictly	ADV
admet-327	113	28	conserved	conserve	VERB
admet-327	113	29	in	in	ADP
admet-327	113	30	aks	ak	NOUN
admet-327	113	31	family	family	NOUN
admet-327	113	32	,	,	PUNCT
admet-327	113	33	are	be	AUX
admet-327	113	34	bolded	bolde	VERB
admet-327	113	35	;	;	PUNCT
admet-327	113	36	in	in	ADP
admet-327	113	37	red	red	NOUN
admet-327	113	38	are	be	AUX
admet-327	113	39	colored	color	VERB
admet-327	113	40	the	the	DET
admet-327	113	41	residues	residue	NOUN
admet-327	113	42	which	which	PRON
admet-327	113	43	interact	interact	VERB
admet-327	113	44	with	with	ADP
admet-327	113	45	2,4	2,4	NUM
admet-327	113	46	-	-	PUNCT
admet-327	113	47	thiazolidinedione	thiazolidinedione	NOUN
admet-327	113	48	the	the	DET
admet-327	113	49	main	main	ADJ
admet-327	113	50	limitation	limitation	NOUN
admet-327	113	51	of	of	ADP
admet-327	113	52	the	the	DET
admet-327	113	53	present	present	ADJ
admet-327	113	54	work	work	NOUN
admet-327	113	55	is	be	AUX
admet-327	113	56	the	the	DET
admet-327	113	57	availability	availability	NOUN
admet-327	113	58	of	of	ADP
admet-327	113	59	aks	ak	NOUN
admet-327	113	60	’	'	PUNCT
admet-327	113	61	crystal	crystal	NOUN
admet-327	113	62	structures	structure	NOUN
admet-327	113	63	deposited	deposit	VERB
admet-327	113	64	in	in	ADP
admet-327	113	65	the	the	DET
admet-327	113	66	public	public	ADJ
admet-327	113	67	databases	database	NOUN
admet-327	113	68	.	.	PUNCT
admet-327	114	1	even	even	ADV
admet-327	114	2	though	though	SCONJ
admet-327	114	3	some	some	DET
admet-327	114	4	databases	database	NOUN
admet-327	114	5	have	have	VERB
admet-327	114	6	some	some	DET
admet-327	114	7	weaknesses	weakness	NOUN
admet-327	114	8	–	–	PUNCT
admet-327	114	9	some	some	PRON
admet-327	114	10	of	of	ADP
admet-327	114	11	them	they	PRON
admet-327	114	12	being	be	AUX
admet-327	114	13	redundant	redundant	ADJ
admet-327	114	14	–	–	PUNCT
admet-327	114	15	they	they	PRON
admet-327	114	16	remain	remain	VERB
admet-327	114	17	a	a	DET
admet-327	114	18	powerful	powerful	ADJ
admet-327	114	19	tool	tool	NOUN
admet-327	114	20	in	in	ADP
admet-327	114	21	fundamental	fundamental	ADJ
admet-327	114	22	research	research	NOUN
admet-327	114	23	.	.	PUNCT
admet-327	115	1	unfortunately	unfortunately	ADV
admet-327	115	2	,	,	PUNCT
admet-327	115	3	kinetic	kinetic	ADJ
admet-327	115	4	experiments	experiment	NOUN
admet-327	115	5	were	be	AUX
admet-327	115	6	not	not	PART
admet-327	115	7	admet	admet	ADJ
admet-327	115	8	&	&	CCONJ
admet-327	115	9	dmpk	dmpk	PROPN
admet-327	115	10	5(1	5(1	NUM
admet-327	115	11	)	)	PUNCT
admet-327	115	12	(	(	PUNCT
admet-327	115	13	2017	2017	NUM
admet-327	115	14	)	)	PUNCT
admet-327	115	15	47	47	NUM
admet-327	115	16	-	-	SYM
admet-327	115	17	56	56	NUM
admet-327	115	18	adenylate	adenylate	ADJ
admet-327	115	19	kinase	kinase	NOUN
admet-327	115	20	inhibition	inhibition	NOUN
admet-327	115	21	by	by	ADP
admet-327	115	22	2,4	2,4	NUM
admet-327	115	23	-	-	PUNCT
admet-327	115	24	thiazolidinedione	thiazolidinedione	ADJ
admet-327	115	25	doi	doi	NOUN
admet-327	115	26	:	:	PUNCT
admet-327	115	27	10.5599	10.5599	NUM
admet-327	115	28	/	/	SYM
admet-327	115	29	admet.5.1.327	admet.5.1.327	PROPN
admet-327	115	30	55	55	NUM
admet-327	115	31	performed	perform	VERB
admet-327	115	32	,	,	PUNCT
admet-327	115	33	which	which	PRON
admet-327	115	34	was	be	AUX
admet-327	115	35	another	another	DET
admet-327	115	36	limit	limit	NOUN
admet-327	115	37	of	of	ADP
admet-327	115	38	the	the	DET
admet-327	115	39	present	present	ADJ
admet-327	115	40	study	study	NOUN
admet-327	115	41	.	.	PUNCT
admet-327	116	1	but	but	CCONJ
admet-327	116	2	the	the	DET
admet-327	116	3	biochemical	biochemical	ADJ
admet-327	116	4	characterization	characterization	NOUN
admet-327	116	5	of	of	ADP
admet-327	116	6	a	a	DET
admet-327	116	7	particular	particular	ADJ
admet-327	116	8	enzyme	enzyme	NOUN
admet-327	116	9	,	,	PUNCT
admet-327	116	10	not	not	PART
admet-327	116	11	always	always	ADV
admet-327	116	12	deciphers	decipher	VERB
admet-327	116	13	all	all	DET
admet-327	116	14	capabilities	capability	NOUN
admet-327	116	15	of	of	ADP
admet-327	116	16	the	the	DET
admet-327	116	17	protein	protein	NOUN
admet-327	116	18	of	of	ADP
admet-327	116	19	interest	interest	NOUN
admet-327	116	20	.	.	PUNCT
admet-327	117	1	to	to	PART
admet-327	117	2	put	put	VERB
admet-327	117	3	these	these	DET
admet-327	117	4	findings	finding	NOUN
admet-327	117	5	in	in	ADP
admet-327	117	6	perspective	perspective	NOUN
admet-327	117	7	,	,	PUNCT
admet-327	117	8	two	two	NUM
admet-327	117	9	approaches	approach	NOUN
admet-327	117	10	could	could	AUX
admet-327	117	11	be	be	AUX
admet-327	117	12	taken	take	VERB
admet-327	117	13	in	in	ADP
admet-327	117	14	consideration	consideration	NOUN
admet-327	117	15	.	.	PUNCT
admet-327	118	1	either	either	CCONJ
admet-327	118	2	the	the	DET
admet-327	118	3	screening	screening	NOUN
admet-327	118	4	of	of	ADP
admet-327	118	5	library	library	ADJ
admet-327	118	6	protein	protein	NOUN
admet-327	118	7	molecules	molecule	NOUN
admet-327	118	8	[	[	X
admet-327	118	9	28	28	NUM
admet-327	118	10	]	]	PUNCT
admet-327	118	11	to	to	PART
admet-327	118	12	find	find	VERB
admet-327	118	13	receptors	receptor	NOUN
admet-327	118	14	to	to	ADP
admet-327	118	15	the	the	DET
admet-327	118	16	highest	high	ADJ
admet-327	118	17	affinity	affinity	NOUN
admet-327	118	18	to	to	ADP
admet-327	118	19	2,4	2,4	NUM
admet-327	118	20	-	-	PUNCT
admet-327	118	21	thiazolidinedione	thiazolidinedione	ADJ
admet-327	118	22	,	,	PUNCT
admet-327	118	23	or	or	CCONJ
admet-327	118	24	design	design	NOUN
admet-327	118	25	novel	novel	ADJ
admet-327	118	26	tzds	tzds	ADJ
admet-327	118	27	derivates	derivate	NOUN
admet-327	118	28	with	with	ADP
admet-327	118	29	better	well	ADJ
admet-327	118	30	binding	bind	VERB
admet-327	118	31	affinity	affinity	NOUN
admet-327	118	32	.	.	PUNCT
admet-327	119	1	inevitably	inevitably	ADV
admet-327	119	2	,	,	PUNCT
admet-327	119	3	inhibitors	inhibitor	NOUN
admet-327	119	4	used	use	VERB
admet-327	119	5	for	for	ADP
admet-327	119	6	bacterial	bacterial	ADJ
admet-327	119	7	infections	infection	NOUN
admet-327	119	8	could	could	AUX
admet-327	119	9	interact	interact	VERB
admet-327	119	10	with	with	ADP
admet-327	119	11	human	human	ADJ
admet-327	119	12	counterpart	counterpart	NOUN
admet-327	119	13	’s	’s	PART
admet-327	119	14	target	target	NOUN
admet-327	119	15	.	.	PUNCT
admet-327	120	1	although	although	SCONJ
admet-327	120	2	these	these	DET
admet-327	120	3	evidences	evidence	NOUN
admet-327	120	4	are	be	AUX
admet-327	120	5	not	not	PART
admet-327	120	6	strong	strong	ADJ
admet-327	120	7	enough	enough	ADV
admet-327	120	8	to	to	PART
admet-327	120	9	persuade	persuade	VERB
admet-327	120	10	us	we	PRON
admet-327	120	11	that	that	SCONJ
admet-327	120	12	2,4	2,4	NUM
admet-327	120	13	-	-	PUNCT
admet-327	120	14	thiazolidinedione	thiazolidinedione	NOUN
admet-327	120	15	is	be	AUX
admet-327	120	16	selective	selective	ADJ
admet-327	120	17	inhibitors	inhibitor	NOUN
admet-327	120	18	for	for	ADP
admet-327	120	19	bacterial	bacterial	ADJ
admet-327	120	20	aks	ak	NOUN
admet-327	120	21	,	,	PUNCT
admet-327	120	22	a	a	DET
admet-327	120	23	novel	novel	ADJ
admet-327	120	24	perspective	perspective	NOUN
admet-327	120	25	of	of	ADP
admet-327	120	26	ak	ak	PROPN
admet-327	120	27	potentiality	potentiality	NOUN
admet-327	120	28	is	be	AUX
admet-327	120	29	revealed	reveal	VERB
admet-327	120	30	.	.	PUNCT
admet-327	121	1	results	result	NOUN
admet-327	121	2	obtained	obtain	VERB
admet-327	121	3	in	in	ADP
admet-327	121	4	this	this	DET
admet-327	121	5	study	study	NOUN
admet-327	121	6	lead	lead	VERB
admet-327	121	7	us	we	PRON
admet-327	121	8	to	to	ADP
admet-327	121	9	the	the	DET
admet-327	121	10	conclusion	conclusion	NOUN
admet-327	121	11	that	that	SCONJ
admet-327	121	12	refining	refine	VERB
admet-327	121	13	the	the	DET
admet-327	121	14	structure	structure	NOUN
admet-327	121	15	of	of	ADP
admet-327	121	16	2,4	2,4	NUM
admet-327	121	17	-	-	PUNCT
admet-327	121	18	thazolidinedione	thazolidinedione	NOUN
admet-327	121	19	could	could	AUX
admet-327	121	20	be	be	AUX
admet-327	121	21	a	a	DET
admet-327	121	22	viable	viable	ADJ
admet-327	121	23	idea	idea	NOUN
admet-327	121	24	in	in	ADP
admet-327	121	25	developing	develop	VERB
admet-327	121	26	potential	potential	ADJ
admet-327	121	27	inhibitors	inhibitor	NOUN
admet-327	121	28	for	for	ADP
admet-327	121	29	vital	vital	ADJ
admet-327	121	30	enzymes	enzyme	NOUN
admet-327	121	31	like	like	ADP
admet-327	121	32	ak	ak	PROPN
admet-327	121	33	.	.	PROPN
admet-327	121	34	conclusions	conclusion	NOUN
admet-327	121	35	this	this	DET
admet-327	121	36	study	study	NOUN
admet-327	121	37	demonstrated	demonstrate	VERB
admet-327	121	38	an	an	DET
admet-327	121	39	effort	effort	NOUN
admet-327	121	40	to	to	PART
admet-327	121	41	reveal	reveal	VERB
admet-327	121	42	interactions	interaction	NOUN
admet-327	121	43	of	of	ADP
admet-327	121	44	ak	ak	PROPN
admet-327	121	45	of	of	ADP
admet-327	121	46	bacterial	bacterial	ADJ
admet-327	121	47	/	/	SYM
admet-327	121	48	human	human	ADJ
admet-327	121	49	origin	origin	NOUN
admet-327	121	50	with	with	ADP
admet-327	121	51	2,4thiazolidinedione	2,4thiazolidinedione	NUM
admet-327	121	52	.	.	PUNCT
admet-327	122	1	the	the	DET
admet-327	122	2	most	most	ADV
admet-327	122	3	noteworthy	noteworthy	ADJ
admet-327	122	4	evidences	evidence	NOUN
admet-327	122	5	were	be	AUX
admet-327	122	6	achieved	achieve	VERB
admet-327	122	7	referring	refer	VERB
admet-327	122	8	to	to	ADP
admet-327	122	9	gram	gram	NOUN
admet-327	122	10	-	-	PUNCT
admet-327	122	11	positive	positive	ADJ
admet-327	122	12	and	and	CCONJ
admet-327	122	13	acid	acid	ADJ
admet-327	122	14	fast	fast	ADJ
admet-327	122	15	bacteria	bacteria	NOUN
admet-327	122	16	’s	’s	PART
admet-327	122	17	aks	ak	NOUN
admet-327	122	18	;	;	PUNCT
admet-327	122	19	2,4	2,4	NUM
admet-327	122	20	-	-	PUNCT
admet-327	122	21	thiazolidinedione	thiazolidinedione	NOUN
admet-327	122	22	interacts	interact	VERB
admet-327	122	23	with	with	ADP
admet-327	122	24	the	the	DET
admet-327	122	25	same	same	ADJ
admet-327	122	26	residues	residue	NOUN
admet-327	122	27	belonging	belong	VERB
admet-327	122	28	to	to	ADP
admet-327	122	29	nmp	nmp	NOUN
admet-327	122	30	-	-	PUNCT
admet-327	122	31	binding	bind	VERB
admet-327	122	32	region	region	NOUN
admet-327	122	33	.	.	PUNCT
admet-327	123	1	further	far	ADV
admet-327	123	2	,	,	PUNCT
admet-327	123	3	the	the	DET
admet-327	123	4	complex	complex	ADJ
admet-327	123	5	comprising	comprising	NOUN
admet-327	123	6	aks	ak	NOUN
admet-327	123	7	of	of	ADP
admet-327	123	8	s.	s.	PROPN
admet-327	123	9	pneumoniae	pneumoniae	PROPN
admet-327	123	10	and	and	CCONJ
admet-327	123	11	m.	m.	NOUN
admet-327	123	12	tuberculosis	tuberculosis	NOUN
admet-327	123	13	exhibit	exhibit	VERB
admet-327	123	14	the	the	DET
admet-327	123	15	same	same	ADJ
admet-327	123	16	ligand	ligand	ADJ
admet-327	123	17	-	-	PUNCT
admet-327	123	18	protein	protein	NOUN
admet-327	123	19	pattern	pattern	NOUN
admet-327	123	20	.	.	PUNCT
admet-327	124	1	human	human	ADJ
admet-327	124	2	aks	ak	NOUN
admet-327	124	3	interactions	interaction	NOUN
admet-327	124	4	with	with	ADP
admet-327	124	5	2,4	2,4	NUM
admet-327	124	6	-	-	PUNCT
admet-327	124	7	thiazolidinedione	thiazolidinedione	NOUN
admet-327	124	8	are	be	AUX
admet-327	124	9	divergent	divergent	ADJ
admet-327	124	10	;	;	PUNCT
admet-327	124	11	a	a	DET
admet-327	124	12	single	single	ADJ
admet-327	124	13	notable	notable	ADJ
admet-327	124	14	connection	connection	NOUN
admet-327	124	15	being	be	AUX
admet-327	124	16	observed	observe	VERB
admet-327	124	17	in	in	ADP
admet-327	124	18	case	case	NOUN
admet-327	124	19	of	of	ADP
admet-327	124	20	mitochondrial	mitochondrial	ADJ
admet-327	124	21	isoenzyme	isoenzyme	NOUN
admet-327	124	22	2	2	NUM
admet-327	124	23	and	and	CCONJ
admet-327	124	24	its	its	PRON
admet-327	124	25	counterpart	counterpart	NOUN
admet-327	124	26	from	from	ADP
admet-327	124	27	e.	e.	PROPN
admet-327	124	28	coli	coli	PROPN
admet-327	124	29	.	.	PUNCT
admet-327	125	1	ak	ak	PROPN
admet-327	125	2	,	,	PUNCT
admet-327	125	3	a	a	DET
admet-327	125	4	small	small	ADJ
admet-327	125	5	enzyme	enzyme	NOUN
admet-327	125	6	needed	need	VERB
admet-327	125	7	for	for	ADP
admet-327	125	8	survival	survival	NOUN
admet-327	125	9	,	,	PUNCT
admet-327	125	10	could	could	AUX
admet-327	125	11	be	be	AUX
admet-327	125	12	an	an	DET
admet-327	125	13	attractive	attractive	ADJ
admet-327	125	14	target	target	NOUN
admet-327	125	15	for	for	ADP
admet-327	125	16	tzds	tzds	ADJ
admet-327	125	17	derivates	derivate	NOUN
admet-327	125	18	,	,	PUNCT
admet-327	125	19	at	at	ADP
admet-327	125	20	least	least	ADJ
admet-327	125	21	in	in	ADP
admet-327	125	22	case	case	NOUN
admet-327	125	23	of	of	ADP
admet-327	125	24	m.	m.	NOUN
admet-327	125	25	tuberculosis	tuberculosis	NOUN
admet-327	125	26	and	and	CCONJ
admet-327	125	27	gram	gram	NOUN
admet-327	125	28	-	-	PUNCT
admet-327	125	29	positive	positive	ADJ
admet-327	125	30	microorganisms	microorganism	NOUN
admet-327	125	31	.	.	PUNCT
admet-327	126	1	acknowledgements	acknowledgement	NOUN
admet-327	126	2	:	:	PUNCT
admet-327	126	3	the	the	DET
admet-327	126	4	author	author	NOUN
admet-327	126	5	would	would	AUX
admet-327	126	6	like	like	VERB
admet-327	126	7	to	to	PART
admet-327	126	8	thank	thank	VERB
admet-327	126	9	the	the	DET
admet-327	126	10	referees	referee	NOUN
admet-327	126	11	for	for	ADP
admet-327	126	12	their	their	PRON
admet-327	126	13	courteously	courteously	ADV
admet-327	126	14	comments	comment	NOUN
admet-327	126	15	.	.	PUNCT
admet-327	127	1	references	reference	NOUN
admet-327	127	2	[	[	X
admet-327	127	3	1	1	NUM
admet-327	127	4	]	]	X
admet-327	127	5	v.d	v.d	PROPN
admet-327	127	6	.	.	PROPN
admet-327	127	7	rosenthal	rosenthal	PROPN
admet-327	127	8	,	,	PUNCT
admet-327	127	9	am	be	AUX
admet-327	127	10	.	.	PUNCT
admet-327	128	1	j.	j.	PROPN
admet-327	128	2	infect	infect	PROPN
admet-327	128	3	.	.	PUNCT
admet-327	129	1	control	control	PROPN
admet-327	129	2	44(6	44(6	PROPN
admet-327	129	3	)	)	PUNCT
admet-327	129	4	(	(	PUNCT
admet-327	129	5	2016	2016	NUM
admet-327	129	6	)	)	PUNCT
admet-327	129	7	e81	e81	NOUN
admet-327	129	8	–	–	PUNCT
admet-327	129	9	e90	e90	NOUN
admet-327	129	10	.	.	PUNCT
admet-327	130	1	[	[	X
admet-327	130	2	2	2	X
admet-327	130	3	]	]	PUNCT
admet-327	130	4	j.	j.	PROPN
admet-327	130	5	perry	perry	PROPN
admet-327	130	6	,	,	PUNCT
admet-327	130	7	n.	n.	PROPN
admet-327	130	8	waglechner	waglechner	PROPN
admet-327	130	9	,	,	PUNCT
admet-327	130	10	g.	g.	PROPN
admet-327	130	11	wright	wright	PROPN
admet-327	130	12	,	,	PUNCT
admet-327	130	13	cold	cold	ADJ
admet-327	130	14	spring	spring	NOUN
admet-327	130	15	harb	harb	PROPN
admet-327	130	16	.	.	PUNCT
admet-327	131	1	perspect	perspect	PROPN
admet-327	131	2	.	.	PUNCT
admet-327	132	1	med	med	PROPN
admet-327	132	2	.	.	PUNCT
admet-327	133	1	6(6	6(6	NUM
admet-327	133	2	)	)	PUNCT
admet-327	133	3	(	(	PUNCT
admet-327	133	4	2016	2016	NUM
admet-327	133	5	)	)	PUNCT
admet-327	133	6	1	1	NUM
admet-327	133	7	-	-	SYM
admet-327	133	8	9	9	NUM
admet-327	133	9	.	.	PUNCT
admet-327	134	1	[	[	X
admet-327	134	2	3	3	X
admet-327	134	3	]	]	PUNCT
admet-327	134	4	m.	m.	NOUN
admet-327	134	5	jamal	jamal	PROPN
admet-327	134	6	,	,	PUNCT
admet-327	134	7	t.	t.	PROPN
admet-327	134	8	hussain	hussain	PROPN
admet-327	134	9	,	,	PUNCT
admet-327	134	10	c.	c.	PROPN
admet-327	134	11	rajanna	rajanna	PROPN
admet-327	134	12	das	das	PROPN
admet-327	134	13	,	,	PUNCT
admet-327	134	14	s.	s.	PROPN
admet-327	134	15	andleeb	andleeb	PROPN
admet-327	134	16	,	,	PUNCT
admet-327	134	17	jundishapur	jundishapur	PROPN
admet-327	134	18	j.	j.	PROPN
admet-327	134	19	microbiol	microbiol	PROPN
admet-327	134	20	.	.	PUNCT
admet-327	135	1	8(11	8(11	NUM
admet-327	135	2	)	)	PUNCT
admet-327	136	1	(	(	PUNCT
admet-327	136	2	2015	2015	NUM
admet-327	136	3	)	)	PUNCT
admet-327	136	4	e25917	e25917	NOUN
admet-327	136	5	.	.	PUNCT
admet-327	137	1	[	[	X
admet-327	137	2	4	4	NUM
admet-327	137	3	]	]	X
admet-327	137	4	g.	g.	NOUN
admet-327	137	5	dinos	dinos	PROPN
admet-327	137	6	,	,	PUNCT
admet-327	137	7	c.	c.	PROPN
admet-327	137	8	athanassopoulos	athanassopoulos	PROPN
admet-327	137	9	,	,	PUNCT
admet-327	137	10	d.	d.	PROPN
admet-327	137	11	missiri	missiri	PROPN
admet-327	137	12	,	,	PUNCT
admet-327	137	13	p.	p.	PROPN
admet-327	137	14	giannopoulou	giannopoulou	PROPN
admet-327	137	15	,	,	PUNCT
admet-327	137	16	i.	i.	PROPN
admet-327	137	17	vlachogiannis	vlachogiannis	PROPN
admet-327	137	18	,	,	PUNCT
admet-327	137	19	g.	g.	PROPN
admet-327	137	20	papadopoulos	papadopoulos	PROPN
admet-327	137	21	,	,	PUNCT
admet-327	137	22	d.	d.	PROPN
admet-327	137	23	papaioannou	papaioannou	PROPN
admet-327	137	24	,	,	PUNCT
admet-327	137	25	d.	d.	PROPN
admet-327	137	26	kalpaxis	kalpaxis	PROPN
admet-327	137	27	,	,	PUNCT
admet-327	137	28	antibiotics	antibiotic	NOUN
admet-327	137	29	5(2	5(2	NUM
admet-327	137	30	)	)	PUNCT
admet-327	137	31	(	(	PUNCT
admet-327	137	32	2016	2016	NUM
admet-327	137	33	)	)	PUNCT
admet-327	137	34	1	1	NUM
admet-327	137	35	-	-	SYM
admet-327	137	36	21	21	NUM
admet-327	137	37	.	.	PUNCT
admet-327	138	1	[	[	X
admet-327	138	2	5	5	X
admet-327	138	3	]	]	PUNCT
admet-327	138	4	j.	j.	PROPN
admet-327	138	5	xia	xia	PROPN
admet-327	138	6	,	,	PUNCT
admet-327	138	7	j.	j.	PROPN
admet-327	138	8	gao	gao	PROPN
admet-327	138	9	,	,	PUNCT
admet-327	138	10	w.	w.	PROPN
admet-327	138	11	tang	tang	PROPN
admet-327	138	12	,	,	PUNCT
admet-327	138	13	biosci	biosci	PROPN
admet-327	138	14	.	.	PUNCT
admet-327	139	1	trends	trend	NOUN
admet-327	139	2	10(1	10(1	NUM
admet-327	139	3	)	)	PUNCT
admet-327	139	4	(	(	PUNCT
admet-327	139	5	2016	2016	NUM
admet-327	139	6	)	)	PUNCT
admet-327	139	7	14–21	14–21	NUM
admet-327	139	8	.	.	PUNCT
admet-327	140	1	[	[	X
admet-327	140	2	6	6	NUM
admet-327	140	3	]	]	X
admet-327	140	4	m.t	m.t	PROPN
admet-327	140	5	.	.	PROPN
admet-327	140	6	htar	htar	PROPN
admet-327	140	7	,	,	PUNCT
admet-327	140	8	d.	d.	PROPN
admet-327	140	9	christopoulou	christopoulou	PROPN
admet-327	140	10	,	,	PUNCT
admet-327	140	11	h.-j	h.-j	PROPN
admet-327	140	12	.	.	PUNCT
admet-327	140	13	schmitt	schmitt	PROPN
admet-327	140	14	,	,	PUNCT
admet-327	140	15	bmc	bmc	NOUN
admet-327	140	16	infect	infect	NOUN
admet-327	140	17	.	.	PUNCT
admet-327	141	1	dis	dis	PROPN
admet-327	141	2	.	.	PROPN
admet-327	142	1	15	15	NUM
admet-327	142	2	(	(	PUNCT
admet-327	142	3	2015	2015	NUM
admet-327	142	4	)	)	PUNCT
admet-327	142	5	1	1	NUM
admet-327	142	6	-	-	SYM
admet-327	142	7	10	10	NUM
admet-327	142	8	.	.	PUNCT
admet-327	143	1	[	[	X
admet-327	143	2	7	7	X
admet-327	143	3	]	]	X
admet-327	143	4	c.	c.	PROPN
admet-327	143	5	trucchi	trucchi	PROPN
admet-327	143	6	,	,	PUNCT
admet-327	143	7	c.	c.	NOUN
admet-327	143	8	paganino	paganino	PROPN
admet-327	143	9	,	,	PUNCT
admet-327	143	10	f.	f.	PROPN
admet-327	143	11	ansaldi	ansaldi	PROPN
admet-327	143	12	,	,	PUNCT
admet-327	143	13	j.	j.	PROPN
admet-327	143	14	prev	prev	PROPN
admet-327	143	15	.	.	PUNCT
admet-327	143	16	med	med	PROPN
admet-327	143	17	.	.	PUNCT
admet-327	144	1	hyg	hyg	PROPN
admet-327	144	2	.	.	PUNCT
admet-327	144	3	56(3	56(3	NUM
admet-327	144	4	)	)	PUNCT
admet-327	144	5	(	(	PUNCT
admet-327	144	6	2015	2015	NUM
admet-327	144	7	)	)	PUNCT
admet-327	145	1	e144	e144	PROPN
admet-327	145	2	–	–	PUNCT
admet-327	145	3	e149	e149	NUM
admet-327	145	4	.	.	PUNCT
admet-327	146	1	[	[	X
admet-327	146	2	8	8	NUM
admet-327	146	3	]	]	PUNCT
admet-327	146	4	t.	t.	NOUN
admet-327	146	5	maitre	maitre	PROPN
admet-327	146	6	,	,	PUNCT
admet-327	146	7	a.	a.	PROPN
admet-327	146	8	aubry	aubry	PROPN
admet-327	146	9	,	,	PUNCT
admet-327	146	10	v.	v.	PROPN
admet-327	146	11	jarlier	jarlier	NOUN
admet-327	146	12	,	,	PUNCT
admet-327	146	13	j.	j.	PROPN
admet-327	146	14	robert	robert	PROPN
admet-327	146	15	,	,	PUNCT
admet-327	146	16	n.	n.	PROPN
admet-327	146	17	veziris	veziris	NOUN
admet-327	146	18	,	,	PUNCT
admet-327	146	19	and	and	CCONJ
admet-327	146	20	cnr	cnr	PROPN
admet-327	146	21	-	-	PUNCT
admet-327	146	22	myrma	myrma	PROPN
admet-327	146	23	,	,	PUNCT
admet-327	146	24	med	med	ADJ
admet-327	146	25	.	.	PUNCT
admet-327	147	1	mal	mal	ADJ
admet-327	147	2	.	.	PUNCT
admet-327	148	1	infect	infect	VERB
admet-327	148	2	.	.	PUNCT
admet-327	149	1	47(1	47(1	NUM
admet-327	149	2	)	)	PUNCT
admet-327	149	3	(	(	PUNCT
admet-327	149	4	2016	2016	NUM
admet-327	149	5	)	)	PUNCT
admet-327	149	6	3	3	NUM
admet-327	149	7	-	-	SYM
admet-327	149	8	10	10	NUM
admet-327	149	9	.	.	PUNCT
admet-327	150	1	[	[	X
admet-327	150	2	9	9	NUM
admet-327	150	3	]	]	X
admet-327	150	4	m.b	m.b	PROPN
admet-327	150	5	.	.	PROPN
admet-327	150	6	berry	berry	NOUN
admet-327	150	7	,	,	PUNCT
admet-327	150	8	g.n.j	g.n.j	PROPN
admet-327	150	9	.	.	PUNCT
admet-327	150	10	phillips	phillips	PROPN
admet-327	150	11	,	,	PUNCT
admet-327	150	12	proteins	protein	NOUN
admet-327	150	13	struct	struct	NOUN
admet-327	150	14	.	.	PUNCT
admet-327	151	1	funct	funct	PROPN
admet-327	151	2	.	.	PUNCT
admet-327	152	1	genet	genet	NOUN
admet-327	152	2	,	,	PUNCT
admet-327	152	3	32(3	32(3	NUM
admet-327	152	4	)	)	PUNCT
admet-327	152	5	(	(	PUNCT
admet-327	152	6	1998	1998	NUM
admet-327	152	7	)	)	PUNCT
admet-327	152	8	276–288	276–288	NUM
admet-327	152	9	.	.	PUNCT
admet-327	153	1	[	[	X
admet-327	153	2	10	10	NUM
admet-327	153	3	]	]	X
admet-327	153	4	k.a	k.a	PROPN
admet-327	153	5	.	.	PROPN
admet-327	153	6	henzler	henzler	PROPN
admet-327	153	7	-	-	PUNCT
admet-327	153	8	wildman	wildman	PROPN
admet-327	153	9	,	,	PUNCT
admet-327	153	10	v.	v.	PROPN
admet-327	153	11	thai	thai	PROPN
admet-327	153	12	,	,	PUNCT
admet-327	153	13	m.	m.	PROPN
admet-327	153	14	lei	lei	PROPN
admet-327	153	15	,	,	PUNCT
admet-327	153	16	m.	m.	PROPN
admet-327	153	17	ott	ott	PROPN
admet-327	153	18	,	,	PUNCT
admet-327	153	19	m.	m.	NOUN
admet-327	153	20	wolf	wolf	NOUN
admet-327	153	21	-	-	PUNCT
admet-327	153	22	watz	watz	NOUN
admet-327	153	23	,	,	PUNCT
admet-327	153	24	t.	t.	PROPN
admet-327	153	25	fenn	fenn	PROPN
admet-327	153	26	,	,	PUNCT
admet-327	153	27	e.	e.	PROPN
admet-327	153	28	pozharski	pozharski	PROPN
admet-327	153	29	,	,	PUNCT
admet-327	153	30	m.a	m.a	PROPN
admet-327	153	31	.	.	PROPN
admet-327	153	32	wilson	wilson	PROPN
admet-327	153	33	,	,	PUNCT
admet-327	153	34	g.a	g.a	PROPN
admet-327	153	35	.	.	PROPN
admet-327	153	36	petsko	petsko	PROPN
admet-327	153	37	,	,	PUNCT
admet-327	153	38	m.	m.	NOUN
admet-327	153	39	karplus	karplus	PROPN
admet-327	153	40	,	,	PUNCT
admet-327	153	41	c.g	c.g	PROPN
admet-327	153	42	.	.	PROPN
admet-327	153	43	hübner	hübner	PROPN
admet-327	153	44	,	,	PUNCT
admet-327	153	45	d.	d.	PROPN
admet-327	153	46	kern	kern	PROPN
admet-327	153	47	,	,	PUNCT
admet-327	153	48	nature	nature	NOUN
admet-327	153	49	450(7171	450(7171	NUM
admet-327	153	50	)	)	PUNCT
admet-327	153	51	(	(	PUNCT
admet-327	153	52	2007	2007	NUM
admet-327	153	53	)	)	PUNCT
admet-327	153	54	838–844	838–844	NUM
admet-327	153	55	.	.	PUNCT
admet-327	154	1	[	[	X
admet-327	154	2	11	11	NUM
admet-327	154	3	]	]	X
admet-327	154	4	m.e	m.e	PROPN
admet-327	154	5	.	.	PROPN
admet-327	154	6	stegenga	stegenga	PROPN
admet-327	154	7	,	,	PUNCT
admet-327	154	8	s.	s.	PROPN
admet-327	154	9	florquin	florquin	PROPN
admet-327	154	10	,	,	PUNCT
admet-327	154	11	a.f	a.f	PROPN
admet-327	154	12	.	.	PROPN
admet-327	154	13	de	de	PROPN
admet-327	154	14	vos	vos	PROPN
admet-327	154	15	,	,	PUNCT
admet-327	154	16	t.	t.	PROPN
admet-327	154	17	van	van	PROPN
admet-327	154	18	der	der	PROPN
admet-327	154	19	poll	poll	NOUN
admet-327	154	20	,	,	PUNCT
admet-327	154	21	crit	crit	PROPN
admet-327	154	22	.	.	PUNCT
admet-327	154	23	care	care	PROPN
admet-327	154	24	med	med	PROPN
admet-327	154	25	.	.	PUNCT
admet-327	155	1	37(2	37(2	PRON
admet-327	155	2	)	)	PUNCT
admet-327	155	3	(	(	PUNCT
admet-327	155	4	2009	2009	NUM
admet-327	155	5	)	)	PUNCT
admet-327	156	1	614–618	614–618	NUM
admet-327	156	2	.	.	PUNCT
admet-327	157	1	[	[	X
admet-327	157	2	12	12	NUM
admet-327	157	3	]	]	X
admet-327	157	4	m.i	m.i	PROPN
admet-327	157	5	.	.	PROPN
admet-327	157	6	ionescu	ionescu	PROPN
admet-327	157	7	,	,	PUNCT
admet-327	157	8	a.z	a.z	PROPN
admet-327	157	9	.	.	PROPN
admet-327	157	10	costache	costache	PROPN
admet-327	157	11	,	,	PUNCT
admet-327	157	12	o.oniga	o.oniga	ADV
admet-327	157	13	,	,	PUNCT
admet-327	157	14	h.l	h.l	PROPN
admet-327	157	15	.	.	PROPN
admet-327	157	16	banciu	banciu	PROPN
admet-327	157	17	,	,	PUNCT
admet-327	157	18	i.lupan	i.lupan	PROPN
admet-327	157	19	,	,	PUNCT
admet-327	157	20	i.	i.	PROPN
admet-327	157	21	lupan	lupan	PROPN
admet-327	157	22	,	,	PUNCT
admet-327	157	23	rom	rom	PROPN
admet-327	157	24	.	.	PUNCT
admet-327	157	25	rev	rev	PROPN
admet-327	157	26	.	.	PROPN
admet-327	158	1	lab	lab	PROPN
admet-327	158	2	.	.	PUNCT
admet-327	159	1	med	med	PROPN
admet-327	159	2	.	.	PUNCT
admet-327	160	1	21(1	21(1	NUM
admet-327	160	2	)	)	PUNCT
admet-327	160	3	(	(	PUNCT
admet-327	160	4	2013	2013	NUM
admet-327	160	5	)	)	PUNCT
admet-327	160	6	93–99	93–99	NUM
admet-327	160	7	.	.	PUNCT
admet-327	161	1	[	[	X
admet-327	161	2	13	13	NUM
admet-327	161	3	]	]	X
admet-327	161	4	d.s	d.s	PROPN
admet-327	161	5	.	.	PROPN
admet-327	161	6	goodsell	goodsell	PROPN
admet-327	161	7	,	,	PUNCT
admet-327	161	8	a.j	a.j	PROPN
admet-327	161	9	.	.	PROPN
admet-327	161	10	olson	olson	PROPN
admet-327	161	11	,	,	PUNCT
admet-327	161	12	proteins	protein	NOUN
admet-327	161	13	struct	struct	NOUN
admet-327	161	14	.	.	PUNCT
admet-327	162	1	funct	funct	PROPN
admet-327	162	2	.	.	PUNCT
admet-327	163	1	genet	genet	NOUN
admet-327	163	2	.	.	PUNCT
admet-327	164	1	8(3	8(3	NUM
admet-327	164	2	)	)	PUNCT
admet-327	164	3	(	(	PUNCT
admet-327	164	4	1990	1990	NUM
admet-327	164	5	)	)	PUNCT
admet-327	165	1	195–202	195–202	NUM
admet-327	165	2	.	.	PUNCT
admet-327	166	1	[	[	X
admet-327	166	2	14	14	NUM
admet-327	166	3	]	]	X
admet-327	166	4	g.m	g.m	PROPN
admet-327	166	5	.	.	PROPN
admet-327	166	6	morris	morris	PROPN
admet-327	166	7	,	,	PUNCT
admet-327	166	8	r.	r.	PROPN
admet-327	166	9	huey	huey	PROPN
admet-327	166	10	,	,	PUNCT
admet-327	166	11	w.	w.	PROPN
admet-327	166	12	lindstrom	lindstrom	PROPN
admet-327	166	13	,	,	PUNCT
admet-327	166	14	m.f	m.f	PROPN
admet-327	166	15	.	.	PROPN
admet-327	166	16	sanner	sanner	PROPN
admet-327	166	17	,	,	PUNCT
admet-327	166	18	r.k	r.k	PROPN
admet-327	166	19	.	.	PROPN
admet-327	166	20	belew	belew	PROPN
admet-327	166	21	,	,	PUNCT
admet-327	166	22	d.s	d.s	PROPN
admet-327	166	23	.	.	PROPN
admet-327	166	24	goodsell	goodsell	PROPN
admet-327	166	25	,	,	PUNCT
admet-327	166	26	a.j	a.j	PROPN
admet-327	166	27	.	.	PROPN
admet-327	166	28	olson	olson	PROPN
admet-327	166	29	,	,	PUNCT
admet-327	166	30	j.	j.	PROPN
admet-327	166	31	comput	comput	PROPN
admet-327	166	32	.	.	PUNCT
admet-327	167	1	chem	chem	NOUN
admet-327	167	2	.	.	PUNCT
admet-327	168	1	30(16	30(16	VERB
admet-327	168	2	)	)	PUNCT
admet-327	168	3	(	(	PUNCT
admet-327	168	4	2009	2009	NUM
admet-327	168	5	)	)	PUNCT
admet-327	168	6	2785–2791	2785–2791	NUM
admet-327	168	7	.	.	PUNCT
admet-327	169	1	[	[	X
admet-327	169	2	15	15	NUM
admet-327	169	3	]	]	X
admet-327	169	4	s.m	s.m	PROPN
admet-327	169	5	.	.	PROPN
admet-327	169	6	rizvi	rizvi	PROPN
admet-327	169	7	,	,	PUNCT
admet-327	169	8	s.	s.	PROPN
admet-327	169	9	shakil	shakil	PROPN
admet-327	169	10	,	,	PUNCT
admet-327	169	11	m.	m.	NOUN
admet-327	169	12	haneef	haneef	PROPN
admet-327	169	13	,	,	PUNCT
admet-327	169	14	excli	excli	PROPN
admet-327	169	15	j.	j.	PROPN
admet-327	169	16	23(12	23(12	PROPN
admet-327	169	17	)	)	PUNCT
admet-327	169	18	(	(	PUNCT
admet-327	169	19	2013	2013	NUM
admet-327	169	20	)	)	PUNCT
admet-327	169	21	831–857	831–857	NUM
admet-327	169	22	.	.	PUNCT
admet-327	170	1	[	[	X
admet-327	170	2	16	16	NUM
admet-327	170	3	]	]	X
admet-327	170	4	g.m	g.m	PROPN
admet-327	170	5	.	.	PROPN
admet-327	170	6	morris	morris	PROPN
admet-327	170	7	,	,	PUNCT
admet-327	170	8	d.s	d.s	PROPN
admet-327	170	9	.	.	PROPN
admet-327	170	10	goodsell	goodsell	PROPN
admet-327	170	11	,	,	PUNCT
admet-327	170	12	r.s	r.s	PROPN
admet-327	170	13	.	.	PROPN
admet-327	170	14	halliday	halliday	PROPN
admet-327	170	15	,	,	PUNCT
admet-327	170	16	r.	r.	PROPN
admet-327	170	17	huey	huey	PROPN
admet-327	170	18	,	,	PUNCT
admet-327	170	19	w.e	w.e	PROPN
admet-327	170	20	.	.	PROPN
admet-327	170	21	hart	hart	PROPN
admet-327	170	22	,	,	PUNCT
admet-327	170	23	r.k	r.k	PROPN
admet-327	170	24	.	.	PROPN
admet-327	170	25	belew	belew	PROPN
admet-327	170	26	,	,	PUNCT
admet-327	170	27	a.j	a.j	PROPN
admet-327	170	28	.	.	PROPN
admet-327	170	29	olson	olson	PROPN
admet-327	170	30	,	,	PUNCT
admet-327	170	31	j.	j.	PROPN
admet-327	170	32	comput	comput	PROPN
admet-327	170	33	.	.	PUNCT
admet-327	171	1	chem	chem	NOUN
admet-327	171	2	.	.	PUNCT
admet-327	172	1	19(14	19(14	NOUN
admet-327	172	2	)	)	PUNCT
admet-327	172	3	(	(	PUNCT
admet-327	172	4	2015	2015	NUM
admet-327	172	5	)	)	PUNCT
admet-327	173	1	e1004586	e1004586	PROPN
admet-327	173	2	.	.	PUNCT
admet-327	174	1	mihaela	mihaela	PROPN
admet-327	174	2	i.	i.	PROPN
admet-327	174	3	ionescu	ionescu	PROPN
admet-327	174	4	admet	admet	PROPN
admet-327	174	5	&	&	CCONJ
admet-327	174	6	dmpk	dmpk	PROPN
admet-327	174	7	5(1	5(1	NUM
admet-327	174	8	)	)	PUNCT
admet-327	174	9	(	(	PUNCT
admet-327	174	10	2017	2017	NUM
admet-327	174	11	)	)	PUNCT
admet-327	174	12	47	47	NUM
admet-327	174	13	-	-	SYM
admet-327	174	14	56	56	NUM
admet-327	174	15	56	56	NUM
admet-327	174	16	[	[	X
admet-327	174	17	17	17	NUM
admet-327	174	18	]	]	X
admet-327	174	19	t.p	t.p	PROPN
admet-327	174	20	.	.	PROPN
admet-327	174	21	schrank	schrank	PROPN
admet-327	174	22	,	,	PUNCT
admet-327	174	23	d.w	d.w	PROPN
admet-327	174	24	.	.	PROPN
admet-327	174	25	bolen	bolen	PROPN
admet-327	174	26	,	,	PUNCT
admet-327	174	27	v.j	v.j	PROPN
admet-327	174	28	.	.	PROPN
admet-327	174	29	hilser	hilser	NOUN
admet-327	174	30	,	,	PUNCT
admet-327	174	31	proc	proc	PROPN
admet-327	174	32	.	.	PUNCT
admet-327	175	1	natl	natl	PROPN
admet-327	175	2	.	.	PUNCT
admet-327	176	1	acad	acad	PROPN
admet-327	176	2	.	.	PUNCT
admet-327	177	1	sci	sci	PROPN
admet-327	177	2	.	.	PUNCT
admet-327	177	3	u.	u.	PROPN
admet-327	177	4	s.	s.	PROPN
admet-327	177	5	a.	a.	PROPN
admet-327	177	6	106(40	106(40	PROPN
admet-327	177	7	)	)	PUNCT
admet-327	177	8	(	(	PUNCT
admet-327	177	9	2009	2009	NUM
admet-327	177	10	)	)	PUNCT
admet-327	177	11	16984–16989	16984–16989	NUM
admet-327	177	12	.	.	PUNCT
admet-327	178	1	[	[	X
admet-327	178	2	18	18	NUM
admet-327	178	3	]	]	X
admet-327	178	4	m.b	m.b	PROPN
admet-327	178	5	.	.	PROPN
admet-327	178	6	berry	berry	PROPN
admet-327	178	7	,	,	PUNCT
admet-327	178	8	b.	b.	PROPN
admet-327	178	9	meador	meador	PROPN
admet-327	178	10	,	,	PUNCT
admet-327	178	11	t.	t.	NOUN
admet-327	178	12	bilderback	bilderback	NOUN
admet-327	178	13	,	,	PUNCT
admet-327	178	14	p.	p.	PROPN
admet-327	178	15	liang	liang	PROPN
admet-327	178	16	,	,	PUNCT
admet-327	178	17	m.	m.	PROPN
admet-327	178	18	glaser	glaser	PROPN
admet-327	178	19	,	,	PUNCT
admet-327	178	20	g.n	g.n	PROPN
admet-327	178	21	.	.	PROPN
admet-327	178	22	phillips	phillips	PROPN
admet-327	178	23	,	,	PUNCT
admet-327	178	24	proteins	protein	NOUN
admet-327	178	25	19(3	19(3	NUM
admet-327	178	26	)	)	PUNCT
admet-327	178	27	(	(	PUNCT
admet-327	178	28	1994	1994	NUM
admet-327	178	29	)	)	PUNCT
admet-327	178	30	183	183	NUM
admet-327	178	31	–	–	SYM
admet-327	178	32	198	198	NUM
admet-327	178	33	.	.	PUNCT
admet-327	179	1	[	[	X
admet-327	179	2	19	19	NUM
admet-327	179	3	]	]	X
admet-327	179	4	t.t	t.t	PROPN
admet-327	179	5	.	.	PROPN
admet-327	179	6	thach	thach	PROPN
admet-327	179	7	,	,	PUNCT
admet-327	179	8	s.	s.	PROPN
admet-327	179	9	lee	lee	PROPN
admet-327	179	10	,	,	PUNCT
admet-327	179	11	acta	acta	PROPN
admet-327	179	12	crystallogr	crystallogr	PROPN
admet-327	179	13	.	.	PUNCT
admet-327	180	1	sect	sect	NOUN
admet-327	180	2	.	.	PUNCT
admet-327	181	1	f	f	PROPN
admet-327	181	2	struct	struct	NOUN
admet-327	181	3	.	.	PUNCT
admet-327	182	1	biol	biol	PROPN
admet-327	182	2	.	.	PUNCT
admet-327	183	1	commun	commun	PROPN
admet-327	183	2	.	.	PUNCT
admet-327	184	1	70(11	70(11	NUM
admet-327	184	2	)	)	PUNCT
admet-327	184	3	(	(	PUNCT
admet-327	184	4	2014	2014	NUM
admet-327	184	5	)	)	PUNCT
admet-327	184	6	1468–1471	1468–1471	NUM
admet-327	184	7	.	.	PUNCT
admet-327	185	1	[	[	X
admet-327	185	2	20	20	NUM
admet-327	185	3	]	]	PUNCT
admet-327	185	4	m.	m.	NOUN
admet-327	185	5	bellinzoni	bellinzoni	NOUN
admet-327	185	6	,	,	PUNCT
admet-327	185	7	a.	a.	NOUN
admet-327	185	8	haouz	haouz	NOUN
admet-327	185	9	,	,	PUNCT
admet-327	185	10	m.	m.	NOUN
admet-327	185	11	graña	graña	ADJ
admet-327	185	12	,	,	PUNCT
admet-327	185	13	h.	h.	PROPN
admet-327	185	14	munier	munier	PROPN
admet-327	185	15	-	-	PUNCT
admet-327	185	16	lehmann	lehmann	PROPN
admet-327	185	17	,	,	PUNCT
admet-327	185	18	w.	w.	PROPN
admet-327	185	19	shepard	shepard	PROPN
admet-327	185	20	,	,	PUNCT
admet-327	185	21	p.m.	p.m.	NOUN
admet-327	185	22	alzari	alzari	PROPN
admet-327	185	23	,	,	PUNCT
admet-327	185	24	protein	protein	NOUN
admet-327	185	25	sci	sci	PROPN
admet-327	185	26	.	.	PUNCT
admet-327	186	1	15(6	15(6	NUM
admet-327	186	2	)	)	PUNCT
admet-327	186	3	(	(	PUNCT
admet-327	186	4	2006	2006	NUM
admet-327	186	5	)	)	PUNCT
admet-327	187	1	1489–1493	1489–1493	NUM
admet-327	187	2	.	.	PUNCT
admet-327	188	1	[	[	X
admet-327	188	2	21	21	NUM
admet-327	188	3	]	]	X
admet-327	188	4	w.	w.	PROPN
admet-327	188	5	li	li	PROPN
admet-327	188	6	,	,	PUNCT
admet-327	188	7	a.	a.	PROPN
admet-327	188	8	cowley	cowley	PROPN
admet-327	188	9	,	,	PUNCT
admet-327	188	10	m.	m.	NOUN
admet-327	188	11	uludag	uludag	PROPN
admet-327	188	12	,	,	PUNCT
admet-327	188	13	t.	t.	PROPN
admet-327	188	14	gur	gur	PROPN
admet-327	188	15	,	,	PUNCT
admet-327	188	16	h.	h.	PROPN
admet-327	188	17	mcwilliam	mcwilliam	PROPN
admet-327	188	18	,	,	PUNCT
admet-327	188	19	s.	s.	PROPN
admet-327	188	20	squizzato	squizzato	PROPN
admet-327	188	21	,	,	PUNCT
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admet-327	188	23	.	.	PROPN
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admet-327	188	25	,	,	PUNCT
admet-327	188	26	n.	n.	PROPN
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admet-327	188	28	,	,	PUNCT
admet-327	188	29	r.	r.	PROPN
admet-327	188	30	lopez	lopez	PROPN
admet-327	188	31	,	,	PUNCT
admet-327	188	32	nucleic	nucleic	ADJ
admet-327	188	33	acids	acid	NOUN
admet-327	188	34	res	re	NOUN
admet-327	188	35	.	.	PUNCT
admet-327	189	1	43	43	NUM
admet-327	189	2	(	(	PUNCT
admet-327	189	3	2015	2015	NUM
admet-327	189	4	)	)	PUNCT
admet-327	189	5	w580–584	w580–584	PROPN
admet-327	189	6	.	.	PUNCT
admet-327	190	1	[	[	X
admet-327	190	2	22	22	NUM
admet-327	190	3	]	]	X
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admet-327	190	5	sievers	sievers	PROPN
admet-327	190	6	,	,	PUNCT
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admet-327	190	11	dineen	dineen	PROPN
admet-327	190	12	,	,	PUNCT
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admet-327	190	14	.	.	PROPN
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admet-327	190	16	,	,	PUNCT
admet-327	190	17	k.	k.	PROPN
admet-327	190	18	karplus	karplus	PROPN
admet-327	190	19	,	,	PUNCT
admet-327	190	20	w.	w.	PROPN
admet-327	190	21	li	li	PROPN
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admet-327	190	24	lopez	lopez	PROPN
admet-327	190	25	,	,	PUNCT
admet-327	190	26	h.	h.	PROPN
admet-327	190	27	mcwilliam	mcwilliam	PROPN
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admet-327	190	30	remmert	remmert	PROPN
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admet-327	190	33	söding	söding	PROPN
admet-327	190	34	,	,	PUNCT
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admet-327	190	38	,	,	PUNCT
admet-327	190	39	d.g	d.g	PROPN
admet-327	190	40	.	.	PROPN
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admet-327	192	2	,	,	PUNCT
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admet-327	192	5	)	)	PUNCT
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admet-327	193	2	.	.	PUNCT
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admet-327	194	2	23	23	NUM
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admet-327	194	5	.	.	PROPN
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admet-327	194	7	,	,	PUNCT
admet-327	194	8	g.e	g.e	PROPN
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admet-327	194	10	schulz	schulz	PROPN
admet-327	194	11	,	,	PUNCT
admet-327	194	12	j.	j.	PROPN
admet-327	194	13	mol	mol	PROPN
admet-327	194	14	.	.	PUNCT
admet-327	194	15	biol	biol	PROPN
admet-327	194	16	.	.	PUNCT
admet-327	195	1	224(1	224(1	NUM
admet-327	195	2	)	)	PUNCT
admet-327	195	3	(	(	PUNCT
admet-327	195	4	1992	1992	NUM
admet-327	195	5	)	)	PUNCT
admet-327	196	1	159–177	159–177	NUM
admet-327	196	2	.	.	PUNCT
admet-327	197	1	[	[	X
admet-327	197	2	24	24	NUM
admet-327	197	3	]	]	X
admet-327	197	4	s.	s.	PROPN
admet-327	197	5	esteban	esteban	PROPN
admet-327	197	6	-	-	PUNCT
admet-327	197	7	martín	martín	PROPN
admet-327	197	8	,	,	PUNCT
admet-327	197	9	r.	r.	PROPN
admet-327	197	10	b.	b.	PROPN
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admet-327	197	18	,	,	PUNCT
admet-327	197	19	c.	c.	PROPN
admet-327	197	20	w.	w.	PROPN
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admet-327	197	22	,	,	PUNCT
admet-327	197	23	v.	v.	ADP
admet-327	197	24	guallar	guallar	ADJ
admet-327	197	25	,	,	PUNCT
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admet-327	197	27	wolf	wolf	NOUN
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admet-327	197	31	x.	x.	NOUN
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admet-327	199	2	)	)	PUNCT
admet-327	199	3	(	(	PUNCT
admet-327	199	4	2014	2014	NUM
admet-327	199	5	)	)	PUNCT
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admet-327	199	7	.	.	PUNCT
admet-327	200	1	[	[	X
admet-327	200	2	25	25	NUM
admet-327	200	3	]	]	X
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admet-327	201	2	,	,	PUNCT
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admet-327	201	14	,	,	PUNCT
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admet-327	202	5	)	)	PUNCT
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admet-327	202	8	35	35	NUM
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admet-327	203	2	26	26	NUM
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admet-327	203	19	)	)	PUNCT
admet-327	203	20	(	(	PUNCT
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admet-327	203	22	)	)	PUNCT
admet-327	203	23	2216–2223	2216–2223	NUM
admet-327	203	24	.	.	PUNCT
admet-327	204	1	[	[	X
admet-327	204	2	27	27	NUM
admet-327	204	3	]	]	X
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admet-327	204	12	,	,	PUNCT
admet-327	204	13	plos	plos	PROPN
admet-327	204	14	comput	comput	PROPN
admet-327	204	15	biol	biol	PROPN
admet-327	204	16	.	.	PUNCT
admet-327	205	1	10(11	10(11	NUM
admet-327	205	2	)	)	PUNCT
admet-327	205	3	(	(	PUNCT
admet-327	205	4	2014	2014	NUM
admet-327	205	5	)	)	PUNCT
admet-327	205	6	e1003938	e1003938	NUM
admet-327	205	7	.	.	PUNCT
admet-327	206	1	[	[	X
admet-327	206	2	28	28	NUM
admet-327	206	3	]	]	X
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admet-327	206	17	.	.	PROPN
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admet-327	206	20	j.m	j.m	PROPN
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admet-327	206	23	,	,	PUNCT
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admet-327	207	2	.	.	PUNCT
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admet-327	208	2	)	)	PUNCT
admet-327	208	3	(	(	PUNCT
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admet-327	208	5	)	)	PUNCT
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admet-327	210	2	2017	2017	NUM
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admet-327	210	4	the	the	DET
admet-327	210	5	authors	author	NOUN
admet-327	210	6	;	;	PUNCT
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admet-327	210	8	iapc	iapc	PROPN
admet-327	210	9	,	,	PUNCT
admet-327	210	10	zagreb	zagreb	PROPN
admet-327	210	11	,	,	PUNCT
admet-327	210	12	croatia	croatia	PROPN
admet-327	210	13	.	.	PUNCT
admet-327	211	1	this	this	DET
admet-327	211	2	article	article	NOUN
admet-327	211	3	is	be	AUX
admet-327	211	4	an	an	DET
admet-327	211	5	open	open	ADJ
admet-327	211	6	-	-	PUNCT
admet-327	211	7	access	access	NOUN
admet-327	211	8	article	article	NOUN
admet-327	211	9	distributed	distribute	VERB
admet-327	211	10	under	under	ADP
admet-327	211	11	the	the	DET
admet-327	211	12	terms	term	NOUN
admet-327	211	13	and	and	CCONJ
admet-327	211	14	conditions	condition	NOUN
admet-327	211	15	of	of	ADP
admet-327	211	16	the	the	DET
admet-327	211	17	creative	creative	ADJ
admet-327	211	18	commons	common	NOUN
admet-327	211	19	attribution	attribution	NOUN
admet-327	211	20	license	license	NOUN
admet-327	211	21	(	(	PUNCT
admet-327	211	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-327	211	23	)	)	PUNCT
admet-327	211	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN