id	sid	tid	token	lemma	pos
admet-341	1	1	manuscript	manuscript	PROPN
admet-341	1	2	doi	doi	PROPN
admet-341	1	3	:	:	PUNCT
admet-341	1	4	10.5599	10.5599	NUM
admet-341	1	5	/	/	SYM
admet-341	1	6	admet.4.4.341	admet.4.4.341	PROPN
admet-341	1	7	314	314	NUM
admet-341	1	8	admet	admet	NOUN
admet-341	1	9	&	&	CCONJ
admet-341	1	10	dmpk	dmpk	PROPN
admet-341	1	11	4(4	4(4	NUM
admet-341	1	12	)	)	PUNCT
admet-341	1	13	(	(	PUNCT
admet-341	1	14	2016	2016	NUM
admet-341	1	15	)	)	PUNCT
admet-341	1	16	314	314	NUM
admet-341	1	17	-	-	SYM
admet-341	1	18	326	326	NUM
admet-341	1	19	;	;	PUNCT
admet-341	1	20	doi	doi	NOUN
admet-341	1	21	:	:	PUNCT
admet-341	1	22	10.5599	10.5599	NUM
admet-341	1	23	/	/	SYM
admet-341	1	24	admet.4.4.341	admet.4.4.341	NOUN
admet-341	1	25	open	open	ADJ
admet-341	1	26	access	access	NOUN
admet-341	1	27	:	:	PUNCT
admet-341	1	28	issn	issn	PROPN
admet-341	1	29	:	:	PUNCT
admet-341	1	30	1848	1848	NUM
admet-341	1	31	-	-	SYM
admet-341	1	32	7718	7718	NUM
admet-341	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-341	1	34	original	original	ADJ
admet-341	1	35	scientific	scientific	ADJ
admet-341	1	36	paper	paper	NOUN
admet-341	1	37	preclinical	preclinical	ADJ
admet-341	1	38	formulation	formulation	NOUN
admet-341	1	39	for	for	ADP
admet-341	1	40	the	the	DET
admet-341	1	41	pharmacokinetics	pharmacokinetic	NOUN
admet-341	1	42	and	and	CCONJ
admet-341	1	43	efficacy	efficacy	NOUN
admet-341	1	44	of	of	ADP
admet-341	1	45	gbo-006	gbo-006	NOUN
admet-341	1	46	,	,	PUNCT
admet-341	1	47	a	a	DET
admet-341	1	48	selective	selective	ADJ
admet-341	1	49	polo	polo	NOUN
admet-341	1	50	like	like	ADP
admet-341	1	51	kinase	kinase	PROPN
admet-341	1	52	2	2	PROPN
admet-341	1	53	(	(	PUNCT
admet-341	1	54	plk2	plk2	NOUN
admet-341	1	55	)	)	PUNCT
admet-341	1	56	inhibitor	inhibitor	NOUN
admet-341	1	57	for	for	ADP
admet-341	1	58	the	the	DET
admet-341	1	59	treatment	treatment	NOUN
admet-341	1	60	of	of	ADP
admet-341	1	61	triple	triple	ADJ
admet-341	1	62	negative	negative	ADJ
admet-341	1	63	breast	breast	NOUN
admet-341	1	64	cancer	cancer	NOUN
admet-341	1	65	srinivas	srinivas	PROPN
admet-341	1	66	maddi1	maddi1	PROPN
admet-341	1	67	*	*	PROPN
admet-341	1	68	,	,	PUNCT
admet-341	1	69	ravi	ravi	PROPN
admet-341	1	70	akkireddy1	akkireddy1	PROPN
admet-341	1	71	,	,	PUNCT
admet-341	1	72	srinivas	srinivas	PROPN
admet-341	1	73	lenkalapelly1	lenkalapelly1	PROPN
admet-341	1	74	,	,	PUNCT
admet-341	1	75	pratima	pratima	PROPN
admet-341	1	76	srivastava1	srivastava1	PROPN
admet-341	1	77	,	,	PUNCT
admet-341	1	78	joshodeep	joshodeep	PROPN
admet-341	1	79	boruwa1	boruwa1	NOUN
admet-341	1	80	,	,	PUNCT
admet-341	1	81	chandra	chandra	PROPN
admet-341	1	82	deb1	deb1	PROPN
admet-341	1	83	,	,	PUNCT
admet-341	1	84	arnab	arnab	PROPN
admet-341	1	85	roy	roy	PROPN
admet-341	1	86	chowdhury1	chowdhury1	PROPN
admet-341	1	87	,	,	PUNCT
admet-341	1	88	duraiswamy	duraiswamy	NOUN
admet-341	1	89	a.	a.	NOUN
admet-341	1	90	jeyaraj1	jeyaraj1	PROPN
admet-341	1	91	,	,	PUNCT
admet-341	1	92	ramana	ramana	PROPN
admet-341	1	93	reddy2	reddy2	PROPN
admet-341	1	94	,	,	PUNCT
admet-341	1	95	premkumar	premkumar	PROPN
admet-341	1	96	reddy3	reddy3	PROPN
admet-341	1	97	,	,	PUNCT
admet-341	1	98	manoj	manoj	PROPN
admet-341	1	99	maniar4	maniar4	PROPN
admet-341	1	100	,	,	PUNCT
admet-341	1	101	sachin	sachin	PROPN
admet-341	1	102	bansal5	bansal5	PROPN
admet-341	1	103	and	and	CCONJ
admet-341	1	104	jang	jang	PROPN
admet-341	1	105	b.	b.	PROPN
admet-341	1	106	gupta1	gupta1	PROPN
admet-341	1	107	1	1	NUM
admet-341	1	108	gvk	gvk	PROPN
admet-341	1	109	biosciences	biosciences	PROPN
admet-341	1	110	pvt	pvt	PROPN
admet-341	1	111	ltd	ltd	PROPN
admet-341	1	112	.	.	PROPN
admet-341	1	113	,	,	PUNCT
admet-341	1	114	nacharam	nacharam	PROPN
admet-341	1	115	,	,	PUNCT
admet-341	1	116	hyderabad	hyderabad	NOUN
admet-341	1	117	500076	500076	NUM
admet-341	1	118	,	,	PUNCT
admet-341	1	119	india	india	PROPN
admet-341	1	120	2	2	NUM
admet-341	1	121	department	department	NOUN
admet-341	1	122	of	of	ADP
admet-341	1	123	structural	structural	ADJ
admet-341	1	124	and	and	CCONJ
admet-341	1	125	chemical	chemical	NOUN
admet-341	1	126	biology	biology	NOUN
admet-341	1	127	,	,	PUNCT
admet-341	1	128	mount	mount	PROPN
admet-341	1	129	sinai	sinai	PROPN
admet-341	1	130	school	school	PROPN
admet-341	1	131	of	of	ADP
admet-341	1	132	medicine	medicine	NOUN
admet-341	1	133	,	,	PUNCT
admet-341	1	134	new	new	PROPN
admet-341	1	135	york	york	PROPN
admet-341	1	136	,	,	PUNCT
admet-341	1	137	ny	ny	PROPN
admet-341	1	138	10029	10029	NUM
admet-341	1	139	3	3	NUM
admet-341	1	140	department	department	NOUN
admet-341	1	141	of	of	ADP
admet-341	1	142	oncological	oncological	ADJ
admet-341	1	143	sciences	science	NOUN
admet-341	1	144	,	,	PUNCT
admet-341	1	145	mount	mount	PROPN
admet-341	1	146	sinai	sinai	PROPN
admet-341	1	147	school	school	PROPN
admet-341	1	148	of	of	ADP
admet-341	1	149	medicine	medicine	NOUN
admet-341	1	150	,	,	PUNCT
admet-341	1	151	new	new	PROPN
admet-341	1	152	york	york	PROPN
admet-341	1	153	,	,	PUNCT
admet-341	1	154	ny	ny	PROPN
admet-341	1	155	10029	10029	NUM
admet-341	1	156	4	4	NUM
admet-341	1	157	onconova	onconova	NOUN
admet-341	1	158	therapeutics	therapeutic	NOUN
admet-341	1	159	,	,	PUNCT
admet-341	1	160	newtown	newtown	PROPN
admet-341	1	161	,	,	PUNCT
admet-341	1	162	pa	pa	PROPN
admet-341	1	163	18940	18940	NUM
admet-341	1	164	5	5	NUM
admet-341	1	165	5asb	5asb	NUM
admet-341	1	166	life	life	NOUN
admet-341	1	167	sciences	sciences	PROPN
admet-341	1	168	pvt	pvt	PROPN
admet-341	1	169	ltd	ltd	PROPN
admet-341	1	170	.	.	PROPN
admet-341	1	171	,	,	PUNCT
admet-341	1	172	nacharam	nacharam	PROPN
admet-341	1	173	,	,	PUNCT
admet-341	1	174	hyderabad	hyderabad	NOUN
admet-341	1	175	500076	500076	NUM
admet-341	1	176	,	,	PUNCT
admet-341	1	177	india	india	PROPN
admet-341	1	178	*	*	PUNCT
admet-341	1	179	corresponding	correspond	VERB
admet-341	1	180	author	author	NOUN
admet-341	1	181	:	:	PUNCT
admet-341	1	182	email	email	NOUN
admet-341	1	183	:	:	PUNCT
admet-341	1	184	srinivasarao.maddi@gvkbio.com	srinivasarao.maddi@gvkbio.com	X
admet-341	1	185	;	;	PUNCT
admet-341	2	1	tel	tel	ADP
admet-341	2	2	:	:	PUNCT
admet-341	2	3	919701166299	919701166299	NUM
admet-341	2	4	.	.	PUNCT
admet-341	3	1	received	receive	VERB
admet-341	3	2	:	:	PUNCT
admet-341	3	3	september	september	PROPN
admet-341	3	4	23	23	NUM
admet-341	3	5	,	,	PUNCT
admet-341	3	6	2016	2016	NUM
admet-341	3	7	;	;	PUNCT
admet-341	3	8	revised	revise	VERB
admet-341	3	9	:	:	PUNCT
admet-341	3	10	december	december	PROPN
admet-341	3	11	13	13	NUM
admet-341	3	12	,	,	PUNCT
admet-341	3	13	2016	2016	NUM
admet-341	3	14	;	;	PUNCT
admet-341	3	15	published	publish	VERB
admet-341	3	16	:	:	PUNCT
admet-341	3	17	december	december	PROPN
admet-341	3	18	26	26	NUM
admet-341	3	19	,	,	PUNCT
admet-341	3	20	2016	2016	NUM
admet-341	3	21	abstract	abstract	ADJ
admet-341	3	22	gbo-006	gbo-006	NOUN
admet-341	3	23	was	be	AUX
admet-341	3	24	shown	show	VERB
admet-341	3	25	to	to	PART
admet-341	3	26	be	be	AUX
admet-341	3	27	a	a	DET
admet-341	3	28	highly	highly	ADV
admet-341	3	29	specific	specific	ADJ
admet-341	3	30	and	and	CCONJ
admet-341	3	31	selective	selective	ADJ
admet-341	3	32	plk2	plk2	NOUN
admet-341	3	33	inhibitor	inhibitor	NOUN
admet-341	3	34	that	that	PRON
admet-341	3	35	promoted	promote	VERB
admet-341	3	36	mitotic	mitotic	ADJ
admet-341	3	37	arrest	arrest	NOUN
admet-341	3	38	in	in	ADP
admet-341	3	39	various	various	ADJ
admet-341	3	40	cancer	cancer	NOUN
admet-341	3	41	cell	cell	NOUN
admet-341	3	42	lines	line	NOUN
admet-341	3	43	,	,	PUNCT
admet-341	3	44	subsequently	subsequently	ADV
admet-341	3	45	resulting	result	VERB
admet-341	3	46	in	in	ADP
admet-341	3	47	their	their	PRON
admet-341	3	48	apoptotic	apoptotic	ADJ
admet-341	3	49	death	death	NOUN
admet-341	3	50	.	.	PUNCT
admet-341	4	1	intraperitoneal	intraperitoneal	ADJ
admet-341	4	2	alternate	alternate	ADJ
admet-341	4	3	day	day	NOUN
admet-341	4	4	dosing	dose	VERB
admet-341	4	5	of	of	ADP
admet-341	4	6	gbo-006	gbo-006	NOUN
admet-341	4	7	using	use	VERB
admet-341	4	8	100	100	NUM
admet-341	4	9	%	%	NOUN
admet-341	4	10	dmso	dmso	NOUN
admet-341	4	11	as	as	SCONJ
admet-341	4	12	formulation	formulation	NOUN
admet-341	4	13	showed	show	VERB
admet-341	4	14	significant	significant	ADJ
admet-341	4	15	tumor	tumor	NOUN
admet-341	4	16	regression	regression	NOUN
admet-341	4	17	in	in	ADP
admet-341	4	18	xenograft	xenograft	NOUN
admet-341	4	19	models	model	NOUN
admet-341	4	20	,	,	PUNCT
admet-341	4	21	demonstrating	demonstrate	VERB
admet-341	4	22	proof	proof	NOUN
admet-341	4	23	of	of	ADP
admet-341	4	24	concept	concept	NOUN
admet-341	4	25	of	of	ADP
admet-341	4	26	plk2	plk2	NOUN
admet-341	4	27	inhibition	inhibition	NOUN
admet-341	4	28	in	in	ADP
admet-341	4	29	vivo	vivo	NOUN
admet-341	4	30	.	.	PUNCT
admet-341	5	1	these	these	DET
admet-341	5	2	studies	study	NOUN
admet-341	5	3	necessitated	necessitate	VERB
admet-341	5	4	the	the	DET
admet-341	5	5	development	development	NOUN
admet-341	5	6	of	of	ADP
admet-341	5	7	a	a	DET
admet-341	5	8	suitable	suitable	ADJ
admet-341	5	9	and	and	CCONJ
admet-341	5	10	gras	gras	PROPN
admet-341	5	11	(	(	PUNCT
admet-341	5	12	generally	generally	ADV
admet-341	5	13	considered	consider	VERB
admet-341	5	14	as	as	ADV
admet-341	5	15	safe	safe	ADJ
admet-341	5	16	)	)	PUNCT
admet-341	5	17	preformulation	preformulation	NOUN
admet-341	5	18	for	for	ADP
admet-341	5	19	pharmacokinetic	pharmacokinetic	ADJ
admet-341	5	20	and	and	CCONJ
admet-341	5	21	efficacy	efficacy	NOUN
admet-341	5	22	studies	study	NOUN
admet-341	5	23	.	.	PUNCT
admet-341	6	1	gbo-006	gbo-006	PROPN
admet-341	6	2	possesses	possesse	NOUN
admet-341	6	3	challenging	challenge	VERB
admet-341	6	4	physicochemical	physicochemical	ADJ
admet-341	6	5	and	and	CCONJ
admet-341	6	6	biopharmaceutical	biopharmaceutical	NOUN
admet-341	6	7	properties	property	NOUN
admet-341	6	8	like	like	ADP
admet-341	6	9	poor	poor	ADJ
admet-341	6	10	solubility	solubility	NOUN
admet-341	6	11	in	in	ADP
admet-341	6	12	aqueous	aqueous	ADJ
admet-341	6	13	media	medium	NOUN
admet-341	6	14	,	,	PUNCT
admet-341	6	15	low	low	ADJ
admet-341	6	16	permeability	permeability	NOUN
admet-341	6	17	and	and	CCONJ
admet-341	6	18	a	a	DET
admet-341	6	19	crystalline	crystalline	ADJ
admet-341	6	20	nature	nature	NOUN
admet-341	6	21	.	.	PUNCT
admet-341	7	1	different	different	ADJ
admet-341	7	2	methods	method	NOUN
admet-341	7	3	like	like	ADP
admet-341	7	4	cosolvency	cosolvency	NOUN
admet-341	7	5	,	,	PUNCT
admet-341	7	6	complexation	complexation	NOUN
admet-341	7	7	and	and	CCONJ
admet-341	7	8	micellar	micellar	ADJ
admet-341	7	9	solubilization	solubilization	NOUN
admet-341	7	10	were	be	AUX
admet-341	7	11	employed	employ	VERB
admet-341	7	12	to	to	PART
admet-341	7	13	improve	improve	VERB
admet-341	7	14	the	the	DET
admet-341	7	15	solubility	solubility	NOUN
admet-341	7	16	of	of	ADP
admet-341	7	17	gbo-006	gbo-006	NOUN
admet-341	7	18	.	.	PUNCT
admet-341	8	1	a	a	DET
admet-341	8	2	strategy	strategy	NOUN
admet-341	8	3	of	of	ADP
admet-341	8	4	co	co	NOUN
admet-341	8	5	-	-	NOUN
admet-341	8	6	solvency	solvency	NOUN
admet-341	8	7	is	be	AUX
admet-341	8	8	used	use	VERB
admet-341	8	9	to	to	PART
admet-341	8	10	solubilize	solubilize	VERB
admet-341	8	11	the	the	DET
admet-341	8	12	gbo-006	gbo-006	NOUN
admet-341	8	13	up	up	ADP
admet-341	8	14	to	to	PART
admet-341	8	15	10	10	NUM
admet-341	8	16	mg	mg	NUM
admet-341	8	17	/	/	SYM
admet-341	8	18	ml	ml	NOUN
admet-341	8	19	.	.	PUNCT
admet-341	9	1	a	a	DET
admet-341	9	2	formulation	formulation	NOUN
admet-341	9	3	with	with	ADP
admet-341	9	4	20	20	NUM
admet-341	9	5	%	%	NOUN
admet-341	9	6	dmso	dmso	NOUN
admet-341	9	7	,	,	PUNCT
admet-341	9	8	40	40	NUM
admet-341	9	9	%	%	NOUN
admet-341	9	10	peg	peg	NOUN
admet-341	9	11	400	400	NUM
admet-341	9	12	,	,	PUNCT
admet-341	9	13	30	30	NUM
admet-341	9	14	%	%	NOUN
admet-341	9	15	of	of	ADP
admet-341	9	16	100	100	NUM
admet-341	9	17	mm	mm	NOUN
admet-341	9	18	citrate	citrate	NOUN
admet-341	9	19	buffer	buffer	NOUN
admet-341	9	20	(	(	PUNCT
admet-341	9	21	ph	ph	NOUN
admet-341	9	22	3.0	3.0	NUM
admet-341	9	23	)	)	PUNCT
admet-341	9	24	and	and	CCONJ
admet-341	9	25	10	10	NUM
admet-341	9	26	%	%	NOUN
admet-341	9	27	solutol	solutol	NOUN
admet-341	9	28	displayed	display	VERB
admet-341	9	29	clear	clear	ADJ
admet-341	9	30	solution	solution	NOUN
admet-341	9	31	without	without	ADP
admet-341	9	32	any	any	DET
admet-341	9	33	visual	visual	ADJ
admet-341	9	34	precipitation	precipitation	NOUN
admet-341	9	35	of	of	ADP
admet-341	9	36	the	the	DET
admet-341	9	37	drug	drug	NOUN
admet-341	9	38	even	even	ADV
admet-341	9	39	after	after	ADP
admet-341	9	40	2	2	NUM
admet-341	9	41	weeks	week	NOUN
admet-341	9	42	of	of	ADP
admet-341	9	43	storage	storage	NOUN
admet-341	9	44	.	.	PUNCT
admet-341	10	1	gbo-006	gbo-006	PROPN
admet-341	10	2	showed	show	VERB
admet-341	10	3	moderate	moderate	ADJ
admet-341	10	4	clearance	clearance	NOUN
admet-341	10	5	in	in	ADP
admet-341	10	6	rat	rat	NOUN
admet-341	10	7	and	and	CCONJ
admet-341	10	8	high	high	ADJ
admet-341	10	9	systemic	systemic	ADJ
admet-341	10	10	clearance	clearance	NOUN
admet-341	10	11	in	in	ADP
admet-341	10	12	mouse	mouse	NOUN
admet-341	10	13	and	and	CCONJ
admet-341	10	14	dog	dog	NOUN
admet-341	10	15	.	.	PUNCT
admet-341	11	1	it	it	PRON
admet-341	11	2	showed	show	VERB
admet-341	11	3	poor	poor	ADJ
admet-341	11	4	oral	oral	ADJ
admet-341	11	5	bioavailability	bioavailability	NOUN
admet-341	11	6	across	across	ADP
admet-341	11	7	all	all	DET
admet-341	11	8	species	specie	NOUN
admet-341	11	9	.	.	PUNCT
admet-341	12	1	intraperitoneal	intraperitoneal	ADJ
admet-341	12	2	dosing	dosing	NOUN
admet-341	12	3	of	of	ADP
admet-341	12	4	gbo-006	gbo-006	NOUN
admet-341	12	5	demonstrated	demonstrate	VERB
admet-341	12	6	the	the	DET
admet-341	12	7	linear	linear	PROPN
admet-341	12	8	exposure	exposure	NOUN
admet-341	12	9	.	.	PUNCT
admet-341	13	1	gbo-006	gbo-006	PROPN
admet-341	13	2	showed	show	VERB
admet-341	13	3	significant	significant	ADJ
admet-341	13	4	inhibition	inhibition	NOUN
admet-341	13	5	of	of	ADP
admet-341	13	6	tumor	tumor	NOUN
admet-341	13	7	progression	progression	NOUN
admet-341	13	8	.	.	PUNCT
admet-341	14	1	keywords	keyword	NOUN
admet-341	14	2	gbo-006	gbo-006	NOUN
admet-341	14	3	;	;	PUNCT
admet-341	14	4	plk2	plk2	NOUN
admet-341	14	5	inhibitor	inhibitor	NOUN
admet-341	14	6	;	;	PUNCT
admet-341	14	7	pharmacokinetics	pharmacokinetic	NOUN
admet-341	14	8	;	;	PUNCT
admet-341	14	9	efficacy	efficacy	NOUN
admet-341	14	10	;	;	PUNCT
admet-341	14	11	triple	triple	ADJ
admet-341	14	12	negative	negative	ADJ
admet-341	14	13	breast	breast	NOUN
admet-341	14	14	cancer	cancer	NOUN
admet-341	14	15	introduction	introduction	NOUN
admet-341	14	16	the	the	DET
admet-341	14	17	up	up	ADJ
admet-341	14	18	regulation	regulation	NOUN
admet-341	14	19	of	of	ADP
admet-341	14	20	polo	polo	NOUN
admet-341	14	21	like	like	ADP
admet-341	14	22	kinase	kinase	PROPN
admet-341	14	23	plk1	plk1	PROPN
admet-341	14	24	plays	play	VERB
admet-341	14	25	a	a	DET
admet-341	14	26	key	key	ADJ
admet-341	14	27	role	role	NOUN
admet-341	14	28	in	in	ADP
admet-341	14	29	mitosis	mitosis	NOUN
admet-341	14	30	but	but	CCONJ
admet-341	14	31	little	little	ADJ
admet-341	14	32	is	be	AUX
admet-341	14	33	known	know	VERB
admet-341	14	34	about	about	ADP
admet-341	14	35	the	the	DET
admet-341	14	36	oncogenic	oncogenic	ADJ
admet-341	14	37	significance	significance	NOUN
admet-341	14	38	of	of	ADP
admet-341	14	39	plk2	plk2	NOUN
admet-341	15	1	[	[	X
admet-341	15	2	1	1	NUM
admet-341	15	3	-	-	SYM
admet-341	15	4	2	2	NUM
admet-341	15	5	]	]	PUNCT
admet-341	15	6	.	.	PUNCT
admet-341	16	1	plk2	plk2	PROPN
admet-341	16	2	kinase	kinase	PROPN
admet-341	16	3	activity	activity	NOUN
admet-341	16	4	is	be	AUX
admet-341	16	5	essential	essential	ADJ
admet-341	16	6	for	for	ADP
admet-341	16	7	centriolar	centriolar	ADJ
admet-341	16	8	duplication	duplication	NOUN
admet-341	16	9	and	and	CCONJ
admet-341	16	10	is	be	AUX
admet-341	16	11	also	also	ADV
admet-341	16	12	believed	believe	VERB
admet-341	16	13	to	to	PART
admet-341	16	14	play	play	VERB
admet-341	16	15	a	a	DET
admet-341	16	16	regulatory	regulatory	ADJ
admet-341	16	17	role	role	NOUN
admet-341	16	18	in	in	ADP
admet-341	16	19	the	the	DET
admet-341	16	20	survival	survival	NOUN
admet-341	16	21	pathway	pathway	NOUN
admet-341	17	1	[	[	X
admet-341	17	2	3	3	NUM
admet-341	17	3	-	-	SYM
admet-341	17	4	5	5	NUM
admet-341	17	5	]	]	PUNCT
admet-341	17	6	.	.	PUNCT
admet-341	18	1	protein	protein	NOUN
admet-341	18	2	tyrosine	tyrosine	NOUN
admet-341	18	3	hyper	hyper	NOUN
admet-341	18	4	-	-	NOUN
admet-341	18	5	phosphorylation	phosphorylation	NOUN
admet-341	18	6	and	and	CCONJ
admet-341	18	7	the	the	DET
admet-341	18	8	up	up	ADJ
admet-341	18	9	regulation	regulation	NOUN
admet-341	18	10	of	of	ADP
admet-341	18	11	serine	serine	NOUN
admet-341	18	12	/	/	SYM
admet-341	18	13	threonine	threonine	ADJ
admet-341	18	14	kinases	kinase	NOUN
admet-341	18	15	associated	associate	VERB
admet-341	18	16	with	with	ADP
admet-341	18	17	cell	cell	NOUN
admet-341	18	18	cycle	cycle	NOUN
admet-341	18	19	progression	progression	NOUN
admet-341	18	20	have	have	AUX
admet-341	18	21	been	be	AUX
admet-341	18	22	linked	link	VERB
admet-341	18	23	to	to	ADP
admet-341	18	24	the	the	DET
admet-341	18	25	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-341	18	26	admet	admet	PROPN
admet-341	18	27	&	&	CCONJ
admet-341	18	28	dmpk	dmpk	PROPN
admet-341	18	29	4(4	4(4	NUM
admet-341	18	30	)	)	PUNCT
admet-341	18	31	(	(	PUNCT
admet-341	18	32	2016	2016	NUM
admet-341	18	33	)	)	PUNCT
admet-341	18	34	314	314	NUM
admet-341	18	35	-	-	SYM
admet-341	18	36	326	326	NUM
admet-341	18	37	pharmacokinetics	pharmacokinetic	NOUN
admet-341	18	38	and	and	CCONJ
admet-341	18	39	efficacy	efficacy	NOUN
admet-341	18	40	of	of	ADP
admet-341	18	41	plk2	plk2	PROPN
admet-341	18	42	inhibitor	inhibitor	NOUN
admet-341	18	43	doi	doi	PROPN
admet-341	18	44	:	:	PUNCT
admet-341	18	45	10.5599	10.5599	NUM
admet-341	18	46	/	/	SYM
admet-341	18	47	admet.4.4.341	admet.4.4.341	PROPN
admet-341	18	48	315	315	NUM
admet-341	18	49	etiology	etiology	NOUN
admet-341	18	50	of	of	ADP
admet-341	18	51	cancer	cancer	NOUN
admet-341	18	52	.	.	PUNCT
admet-341	19	1	in	in	ADP
admet-341	19	2	our	our	PRON
admet-341	19	3	attempt	attempt	NOUN
admet-341	19	4	to	to	PART
admet-341	19	5	develop	develop	VERB
admet-341	19	6	atp	atp	NOUN
admet-341	19	7	-	-	PUNCT
admet-341	19	8	mimetic	mimetic	ADJ
admet-341	19	9	compounds	compound	NOUN
admet-341	19	10	that	that	PRON
admet-341	19	11	are	be	AUX
admet-341	19	12	cytotoxic	cytotoxic	ADJ
admet-341	19	13	against	against	ADP
admet-341	19	14	a	a	DET
admet-341	19	15	panel	panel	NOUN
admet-341	19	16	of	of	ADP
admet-341	19	17	cancer	cancer	NOUN
admet-341	19	18	cell	cell	NOUN
admet-341	19	19	lines	line	NOUN
admet-341	19	20	,	,	PUNCT
admet-341	19	21	we	we	PRON
admet-341	19	22	identified	identify	VERB
admet-341	19	23	several	several	ADJ
admet-341	19	24	sulfonyl	sulfonyl	NOUN
admet-341	19	25	pyridopyrimidines	pyridopyrimidine	NOUN
admet-341	19	26	that	that	PRON
admet-341	19	27	exhibit	exhibit	VERB
admet-341	19	28	cyto	cyto	NOUN
admet-341	19	29	-	-	PUNCT
admet-341	19	30	toxicity	toxicity	NOUN
admet-341	19	31	at	at	ADP
admet-341	19	32	nanomolar	nanomolar	ADJ
admet-341	19	33	concentrations	concentration	NOUN
admet-341	19	34	[	[	X
admet-341	19	35	6	6	NUM
admet-341	19	36	-	-	SYM
admet-341	19	37	8	8	NUM
admet-341	19	38	]	]	PUNCT
admet-341	19	39	.	.	PUNCT
admet-341	20	1	the	the	DET
admet-341	20	2	most	most	ADV
admet-341	20	3	potent	potent	NOUN
admet-341	20	4	of	of	ADP
admet-341	20	5	these	these	DET
admet-341	20	6	compounds	compound	NOUN
admet-341	20	7	,	,	PUNCT
admet-341	20	8	gbo-006	gbo-006	NOUN
admet-341	20	9	(	(	PUNCT
admet-341	20	10	2-(1h	2-(1h	PROPN
admet-341	20	11	-	-	PUNCT
admet-341	20	12	indol-5	indol-5	CCONJ
admet-341	20	13	-	-	PUNCT
admet-341	20	14	ylamino)-6-(2,4difluorophenylsulfonyl)-8	ylamino)-6-(2,4difluorophenylsulfonyl)-8	NOUN
admet-341	20	15	-	-	PUNCT
admet-341	20	16	methylpyrido[2,3	methylpyrido[2,3	NOUN
admet-341	20	17	-	-	NOUN
admet-341	20	18	d]pyrimidin-7(8h)-one	d]pyrimidin-7(8h)-one	NOUN
admet-341	20	19	)	)	PUNCT
admet-341	20	20	was	be	AUX
admet-341	20	21	found	find	VERB
admet-341	20	22	to	to	PART
admet-341	20	23	be	be	AUX
admet-341	20	24	a	a	DET
admet-341	20	25	specific	specific	ADJ
admet-341	20	26	plk2	plk2	NOUN
admet-341	20	27	inhibitor	inhibitor	NOUN
admet-341	20	28	when	when	SCONJ
admet-341	20	29	profiled	profile	VERB
admet-341	20	30	against	against	ADP
admet-341	20	31	a	a	DET
admet-341	20	32	panel	panel	NOUN
admet-341	20	33	of	of	ADP
admet-341	20	34	288	288	NUM
admet-341	20	35	wild	wild	ADJ
admet-341	20	36	-	-	PUNCT
admet-341	20	37	type	type	NOUN
admet-341	20	38	,	,	PUNCT
admet-341	20	39	55	55	NUM
admet-341	20	40	mutant	mutant	NOUN
admet-341	20	41	and	and	CCONJ
admet-341	20	42	12	12	NUM
admet-341	20	43	special	special	ADJ
admet-341	20	44	kinases	kinase	NOUN
admet-341	20	45	.	.	PUNCT
admet-341	21	1	in	in	ADP
admet-341	21	2	vitro	vitro	X
admet-341	21	3	testing	testing	NOUN
admet-341	21	4	revealed	reveal	VERB
admet-341	21	5	that	that	SCONJ
admet-341	21	6	gbo-006	gbo-006	NOUN
admet-341	21	7	was	be	AUX
admet-341	21	8	found	find	VERB
admet-341	21	9	to	to	PART
admet-341	21	10	be	be	AUX
admet-341	21	11	plk2	plk2	VERB
admet-341	21	12	specific	specific	ADJ
admet-341	21	13	and	and	CCONJ
admet-341	21	14	selective	selective	ADJ
admet-341	21	15	inhibitor	inhibitor	NOUN
admet-341	21	16	with	with	ADP
admet-341	21	17	nanomolar	nanomolar	ADJ
admet-341	21	18	potency	potency	NOUN
admet-341	21	19	and	and	CCONJ
admet-341	21	20	no	no	DET
admet-341	21	21	inhibitory	inhibitory	ADJ
admet-341	21	22	activity	activity	NOUN
admet-341	21	23	against	against	ADP
admet-341	21	24	plk1	plk1	PROPN
admet-341	21	25	,	,	PUNCT
admet-341	21	26	plk3	plk3	PROPN
admet-341	21	27	and	and	CCONJ
admet-341	21	28	plk4	plk4	PROPN
admet-341	21	29	.	.	PUNCT
admet-341	22	1	the	the	DET
admet-341	22	2	cytotoxic	cytotoxic	ADJ
admet-341	22	3	effect	effect	NOUN
admet-341	22	4	of	of	ADP
admet-341	22	5	the	the	DET
admet-341	22	6	drug	drug	NOUN
admet-341	22	7	is	be	AUX
admet-341	22	8	mediated	mediate	VERB
admet-341	22	9	by	by	ADP
admet-341	22	10	apoptosis	apoptosis	NOUN
admet-341	22	11	as	as	SCONJ
admet-341	22	12	evidenced	evidence	VERB
admet-341	22	13	by	by	ADP
admet-341	22	14	the	the	DET
admet-341	22	15	induction	induction	NOUN
admet-341	22	16	of	of	ADP
admet-341	22	17	caspase	caspase	NOUN
admet-341	22	18	3/7	3/7	NUM
admet-341	22	19	activity	activity	NOUN
admet-341	22	20	and	and	CCONJ
admet-341	22	21	by	by	ADP
admet-341	22	22	the	the	DET
admet-341	22	23	cleavage	cleavage	NOUN
admet-341	22	24	of	of	ADP
admet-341	22	25	parp	parp	NOUN
admet-341	22	26	in	in	ADP
admet-341	22	27	a	a	DET
admet-341	22	28	dose	dose	ADJ
admet-341	22	29	dependent	dependent	ADJ
admet-341	22	30	manner	manner	NOUN
admet-341	23	1	[	[	X
admet-341	23	2	9	9	NUM
admet-341	23	3	]	]	PUNCT
admet-341	23	4	.	.	PUNCT
admet-341	24	1	it	it	PRON
admet-341	24	2	affects	affect	VERB
admet-341	24	3	cell	cell	NOUN
admet-341	24	4	cycle	cycle	NOUN
admet-341	24	5	progression	progression	NOUN
admet-341	24	6	by	by	ADP
admet-341	24	7	blocking	block	VERB
admet-341	24	8	tumor	tumor	NOUN
admet-341	24	9	cells	cell	NOUN
admet-341	24	10	in	in	ADP
admet-341	24	11	the	the	DET
admet-341	24	12	g2	g2	PROPN
admet-341	24	13	/	/	SYM
admet-341	24	14	m	m	PROPN
admet-341	24	15	phase	phase	NOUN
admet-341	24	16	.	.	PUNCT
admet-341	25	1	intraperitoneal	intraperitoneal	ADJ
admet-341	25	2	alternate	alternate	ADJ
admet-341	25	3	day	day	NOUN
admet-341	25	4	dosing	dose	VERB
admet-341	25	5	of	of	ADP
admet-341	25	6	gbo-006	gbo-006	NOUN
admet-341	25	7	using	use	VERB
admet-341	25	8	100	100	NUM
admet-341	25	9	%	%	NOUN
admet-341	25	10	dmso	dmso	NOUN
admet-341	25	11	as	as	ADP
admet-341	25	12	formulation	formulation	NOUN
admet-341	25	13	lead	lead	NOUN
admet-341	25	14	to	to	ADP
admet-341	25	15	significant	significant	ADJ
admet-341	25	16	tumor	tumor	NOUN
admet-341	25	17	regression	regression	NOUN
admet-341	25	18	in	in	ADP
admet-341	25	19	xenograft	xenograft	NOUN
admet-341	25	20	models	model	NOUN
admet-341	25	21	,	,	PUNCT
admet-341	25	22	demonstrating	demonstrate	VERB
admet-341	25	23	proof	proof	NOUN
admet-341	25	24	of	of	ADP
admet-341	25	25	concept	concept	NOUN
admet-341	25	26	of	of	ADP
admet-341	25	27	plk2	plk2	NOUN
admet-341	25	28	inhibition	inhibition	NOUN
admet-341	25	29	in	in	ADP
admet-341	25	30	vivo	vivo	NOUN
admet-341	25	31	.	.	PUNCT
admet-341	26	1	however	however	ADV
admet-341	26	2	,	,	PUNCT
admet-341	26	3	gbo-006	gbo-006	PROPN
admet-341	26	4	showed	show	VERB
admet-341	26	5	poor	poor	ADJ
admet-341	26	6	solubility	solubility	NOUN
admet-341	26	7	in	in	ADP
admet-341	26	8	aqueous	aqueous	ADJ
admet-341	26	9	media	medium	NOUN
admet-341	26	10	(	(	PUNCT
admet-341	26	11	<	<	X
admet-341	26	12	0.1	0.1	NUM
admet-341	26	13	μg	μg	NOUN
admet-341	26	14	/	/	SYM
admet-341	26	15	ml	ml	NOUN
admet-341	26	16	)	)	PUNCT
admet-341	26	17	,	,	PUNCT
admet-341	26	18	had	have	VERB
admet-341	26	19	a	a	DET
admet-341	26	20	low	low	ADJ
admet-341	26	21	permeability	permeability	NOUN
admet-341	26	22	and	and	CCONJ
admet-341	26	23	a	a	DET
admet-341	26	24	crystalline	crystalline	ADJ
admet-341	26	25	nature	nature	NOUN
admet-341	26	26	,	,	PUNCT
admet-341	26	27	making	make	VERB
admet-341	26	28	it	it	PRON
admet-341	26	29	very	very	ADV
admet-341	26	30	hard	hard	ADV
admet-341	26	31	to	to	PART
admet-341	26	32	have	have	VERB
admet-341	26	33	a	a	DET
admet-341	26	34	feasible	feasible	ADJ
admet-341	26	35	formulation	formulation	NOUN
admet-341	26	36	with	with	ADP
admet-341	26	37	moderate	moderate	ADJ
admet-341	26	38	concentration	concentration	NOUN
admet-341	26	39	,	,	PUNCT
admet-341	26	40	prompting	prompt	VERB
admet-341	26	41	studies	study	NOUN
admet-341	26	42	to	to	PART
admet-341	26	43	develop	develop	VERB
admet-341	26	44	a	a	DET
admet-341	26	45	preclinical	preclinical	ADJ
admet-341	26	46	formulation	formulation	NOUN
admet-341	26	47	.	.	PUNCT
admet-341	27	1	in	in	ADP
admet-341	27	2	this	this	DET
admet-341	27	3	paper	paper	NOUN
admet-341	27	4	,	,	PUNCT
admet-341	27	5	we	we	PRON
admet-341	27	6	have	have	AUX
admet-341	27	7	presented	present	VERB
admet-341	27	8	the	the	DET
admet-341	27	9	use	use	NOUN
admet-341	27	10	of	of	ADP
admet-341	27	11	co	co	ADJ
admet-341	27	12	-	-	ADJ
admet-341	27	13	solvent	solvent	ADJ
admet-341	27	14	based	base	VERB
admet-341	27	15	formulation	formulation	NOUN
admet-341	27	16	to	to	PART
admet-341	27	17	increase	increase	VERB
admet-341	27	18	the	the	DET
admet-341	27	19	solubility	solubility	NOUN
admet-341	27	20	of	of	ADP
admet-341	27	21	the	the	DET
admet-341	27	22	compound	compound	NOUN
admet-341	27	23	.	.	PUNCT
admet-341	28	1	the	the	DET
admet-341	28	2	developed	develop	VERB
admet-341	28	3	formulation	formulation	NOUN
admet-341	28	4	was	be	AUX
admet-341	28	5	subsequently	subsequently	ADV
admet-341	28	6	used	use	VERB
admet-341	28	7	to	to	PART
admet-341	28	8	perform	perform	VERB
admet-341	28	9	pharmacokinetic	pharmacokinetic	ADJ
admet-341	28	10	studies	study	NOUN
admet-341	28	11	(	(	PUNCT
admet-341	28	12	mice	mouse	NOUN
admet-341	28	13	,	,	PUNCT
admet-341	28	14	rats	rat	NOUN
admet-341	28	15	and	and	CCONJ
admet-341	28	16	dogs	dog	NOUN
admet-341	28	17	)	)	PUNCT
admet-341	28	18	and	and	CCONJ
admet-341	28	19	efficacy	efficacy	NOUN
admet-341	28	20	studies	study	NOUN
admet-341	28	21	,	,	PUNCT
admet-341	28	22	with	with	ADP
admet-341	28	23	gbo-006	gbo-006	NOUN
admet-341	28	24	as	as	ADP
admet-341	28	25	a	a	DET
admet-341	28	26	single	single	ADJ
admet-341	28	27	agent	agent	NOUN
admet-341	28	28	in	in	ADP
admet-341	28	29	scid	scid	PROPN
admet-341	28	30	beige	beige	PROPN
admet-341	28	31	mouse	mouse	PROPN
admet-341	28	32	xenograft	xenograft	NOUN
admet-341	28	33	models	model	NOUN
admet-341	28	34	.	.	PUNCT
admet-341	29	1	materials	material	NOUN
admet-341	29	2	and	and	CCONJ
admet-341	29	3	methods	method	NOUN
admet-341	29	4	chemicals	chemical	NOUN
admet-341	29	5	and	and	CCONJ
admet-341	29	6	reagents	reagent	NOUN
admet-341	29	7	gbo-006	gbo-006	NOUN
admet-341	29	8	was	be	AUX
admet-341	29	9	synthesized	synthesize	VERB
admet-341	29	10	with	with	ADP
admet-341	29	11	the	the	DET
admet-341	29	12	purity	purity	NOUN
admet-341	29	13	of	of	ADP
admet-341	29	14	99.5	99.5	NUM
admet-341	29	15	%	%	NOUN
admet-341	29	16	in	in	ADP
admet-341	29	17	-	-	PUNCT
admet-341	29	18	house	house	NOUN
admet-341	29	19	(	(	PUNCT
admet-341	29	20	gvk	gvk	PROPN
admet-341	29	21	biosciences	biosciences	PROPN
admet-341	29	22	pvt	pvt	PROPN
admet-341	29	23	.	.	PROPN
admet-341	29	24	ltd	ltd	PROPN
admet-341	29	25	,	,	PUNCT
admet-341	29	26	hyderabad	hyderabad	PROPN
admet-341	29	27	,	,	PUNCT
admet-341	29	28	india	india	PROPN
admet-341	29	29	)	)	PUNCT
admet-341	29	30	.	.	PUNCT
admet-341	30	1	all	all	DET
admet-341	30	2	co	co	NOUN
admet-341	30	3	-	-	NOUN
admet-341	30	4	solvents	solvent	NOUN
admet-341	30	5	,	,	PUNCT
admet-341	30	6	surfactants	surfactant	NOUN
admet-341	30	7	,	,	PUNCT
admet-341	30	8	solutol	solutol	ADJ
admet-341	30	9	,	,	PUNCT
admet-341	30	10	glycerin	glycerin	NOUN
admet-341	30	11	,	,	PUNCT
admet-341	30	12	complexing	complexe	VERB
admet-341	30	13	agents	agent	NOUN
admet-341	30	14	,	,	PUNCT
admet-341	30	15	lipids	lipid	NOUN
admet-341	30	16	and	and	CCONJ
admet-341	30	17	oils	oil	NOUN
admet-341	30	18	were	be	AUX
admet-341	30	19	purchased	purchase	VERB
admet-341	30	20	from	from	ADP
admet-341	30	21	sigma	sigma	PROPN
admet-341	30	22	-	-	PUNCT
admet-341	30	23	aldrich	aldrich	PROPN
admet-341	30	24	(	(	PUNCT
admet-341	30	25	st	st	PROPN
admet-341	30	26	.	.	PROPN
admet-341	30	27	louis	louis	PROPN
admet-341	30	28	,	,	PUNCT
admet-341	30	29	usa	usa	PROPN
admet-341	30	30	)	)	PUNCT
admet-341	30	31	.	.	PUNCT
admet-341	31	1	liquid	liquid	ADJ
admet-341	31	2	chromatography	chromatography	NOUN
admet-341	31	3	grade	grade	NOUN
admet-341	31	4	acetonitrile	acetonitrile	NOUN
admet-341	31	5	,	,	PUNCT
admet-341	31	6	methanol	methanol	NOUN
admet-341	31	7	and	and	CCONJ
admet-341	31	8	ethanol	ethanol	NOUN
admet-341	31	9	were	be	AUX
admet-341	31	10	purchased	purchase	VERB
admet-341	31	11	from	from	ADP
admet-341	31	12	e.	e.	PROPN
admet-341	31	13	merck	merck	PROPN
admet-341	31	14	limited	limited	PROPN
admet-341	31	15	(	(	PUNCT
admet-341	31	16	mumbai	mumbai	PROPN
admet-341	31	17	,	,	PUNCT
admet-341	31	18	india	india	PROPN
admet-341	31	19	)	)	PUNCT
admet-341	31	20	.	.	PUNCT
admet-341	32	1	multi	multi	ADJ
admet-341	32	2	-	-	ADJ
admet-341	32	3	screen	screen	ADJ
admet-341	32	4	solvinert	solvinert	NOUN
admet-341	32	5	inert	inert	NOUN
admet-341	32	6	filter	filter	NOUN
admet-341	32	7	plates	plate	NOUN
admet-341	32	8	(	(	PUNCT
admet-341	32	9	0.45	0.45	NUM
admet-341	32	10	μm	μm	NOUN
admet-341	32	11	,	,	PUNCT
admet-341	32	12	low	low	ADJ
admet-341	32	13	binding	bind	VERB
admet-341	32	14	hydrophilic	hydrophilic	ADJ
admet-341	32	15	ptfe	ptfe	NOUN
admet-341	32	16	)	)	PUNCT
admet-341	32	17	were	be	AUX
admet-341	32	18	purchased	purchase	VERB
admet-341	32	19	from	from	ADP
admet-341	32	20	millipore	millipore	PROPN
admet-341	32	21	.	.	PUNCT
admet-341	33	1	all	all	DET
admet-341	33	2	aqueous	aqueous	ADJ
admet-341	33	3	solutions	solution	NOUN
admet-341	33	4	were	be	AUX
admet-341	33	5	prepared	prepare	VERB
admet-341	33	6	in	in	ADP
admet-341	33	7	mili	mili	NOUN
admet-341	33	8	-	-	PUNCT
admet-341	33	9	q	q	NOUN
admet-341	33	10	water	water	NOUN
admet-341	33	11	(	(	PUNCT
admet-341	33	12	millipore	millipore	PROPN
admet-341	33	13	,	,	PUNCT
admet-341	33	14	ma	ma	PROPN
admet-341	33	15	)	)	PUNCT
admet-341	33	16	.	.	PUNCT
admet-341	34	1	all	all	DET
admet-341	34	2	other	other	ADJ
admet-341	34	3	chemicals	chemical	NOUN
admet-341	34	4	were	be	AUX
admet-341	34	5	of	of	ADP
admet-341	34	6	analytical	analytical	ADJ
admet-341	34	7	grade	grade	NOUN
admet-341	34	8	.	.	PUNCT
admet-341	35	1	matrigel	matrigel	NOUN
admet-341	35	2	was	be	AUX
admet-341	35	3	procured	procure	VERB
admet-341	35	4	from	from	ADP
admet-341	35	5	sigmaaldrich	sigmaaldrich	PROPN
admet-341	35	6	(	(	PUNCT
admet-341	35	7	dlw356235	dlw356235	PROPN
admet-341	35	8	)	)	PUNCT
admet-341	35	9	.	.	PUNCT
admet-341	36	1	solubility	solubility	NOUN
admet-341	36	2	studies	study	NOUN
admet-341	36	3	solubilization	solubilization	NOUN
admet-341	36	4	approach	approach	NOUN
admet-341	36	5	using	use	VERB
admet-341	36	6	co	co	NOUN
admet-341	36	7	-	-	NOUN
admet-341	36	8	solvent(s	solvent(s	NOUN
admet-341	36	9	)	)	PUNCT
admet-341	36	10	and	and	CCONJ
admet-341	36	11	surfactant(s	surfactant(s	NOUN
admet-341	36	12	)	)	PUNCT
admet-341	36	13	were	be	AUX
admet-341	36	14	tried	try	VERB
admet-341	36	15	to	to	PART
admet-341	36	16	optimize	optimize	VERB
admet-341	36	17	the	the	DET
admet-341	36	18	best	good	ADJ
admet-341	36	19	formulation	formulation	NOUN
admet-341	36	20	for	for	ADP
admet-341	36	21	pharmacokinetic	pharmacokinetic	ADJ
admet-341	36	22	and	and	CCONJ
admet-341	36	23	efficacy	efficacy	NOUN
admet-341	36	24	studies	study	NOUN
admet-341	36	25	.	.	PUNCT
admet-341	37	1	to	to	PART
admet-341	37	2	estimate	estimate	VERB
admet-341	37	3	solubility	solubility	NOUN
admet-341	37	4	qualitatively	qualitatively	ADV
admet-341	37	5	,	,	PUNCT
admet-341	37	6	known	know	VERB
admet-341	37	7	amount	amount	NOUN
admet-341	37	8	of	of	ADP
admet-341	37	9	gbo-006	gbo-006	NOUN
admet-341	37	10	was	be	AUX
admet-341	37	11	taken	take	VERB
admet-341	37	12	in	in	ADP
admet-341	37	13	clear	clear	ADJ
admet-341	37	14	glass	glass	NOUN
admet-341	37	15	vial	vial	NOUN
admet-341	37	16	.	.	PUNCT
admet-341	38	1	to	to	ADP
admet-341	38	2	this	this	PRON
admet-341	38	3	,	,	PUNCT
admet-341	38	4	known	known	ADJ
admet-341	38	5	volume	volume	NOUN
admet-341	38	6	of	of	ADP
admet-341	38	7	test	test	NOUN
admet-341	38	8	media	medium	NOUN
admet-341	38	9	was	be	AUX
admet-341	38	10	added	add	VERB
admet-341	38	11	and	and	CCONJ
admet-341	38	12	observed	observe	VERB
admet-341	38	13	for	for	ADP
admet-341	38	14	clarity	clarity	NOUN
admet-341	38	15	.	.	PUNCT
admet-341	39	1	gbo006	gbo006	PROPN
admet-341	39	2	was	be	AUX
admet-341	39	3	dissolved	dissolve	VERB
admet-341	39	4	in	in	ADP
admet-341	39	5	nearly	nearly	ADV
admet-341	39	6	30	30	NUM
admet-341	39	7	-	-	SYM
admet-341	39	8	80	80	NUM
admet-341	39	9	%	%	NOUN
admet-341	39	10	of	of	ADP
admet-341	39	11	mixtures	mixture	NOUN
admet-341	39	12	of	of	ADP
admet-341	39	13	co	co	NOUN
admet-341	39	14	-	-	NOUN
admet-341	39	15	solvents	solvent	NOUN
admet-341	39	16	with	with	ADP
admet-341	39	17	the	the	DET
admet-341	39	18	aid	aid	NOUN
admet-341	39	19	of	of	ADP
admet-341	39	20	heating	heating	NOUN
admet-341	39	21	and	and	CCONJ
admet-341	39	22	bath	bath	NOUN
admet-341	39	23	sonication	sonication	NOUN
admet-341	39	24	as	as	ADP
admet-341	39	25	and	and	CCONJ
admet-341	39	26	when	when	SCONJ
admet-341	39	27	required	require	VERB
admet-341	39	28	.	.	PUNCT
admet-341	40	1	aqueous	aqueous	ADJ
admet-341	40	2	medium	medium	NOUN
admet-341	40	3	was	be	AUX
admet-341	40	4	added	add	VERB
admet-341	40	5	only	only	ADV
admet-341	40	6	if	if	SCONJ
admet-341	40	7	solution	solution	NOUN
admet-341	40	8	was	be	AUX
admet-341	40	9	obtained	obtain	VERB
admet-341	40	10	in	in	ADP
admet-341	40	11	co	co	NOUN
admet-341	40	12	-	-	NOUN
admet-341	40	13	solvents	solvent	NOUN
admet-341	40	14	.	.	PUNCT
admet-341	41	1	aqueous	aqueous	ADJ
admet-341	41	2	medium	medium	NOUN
admet-341	41	3	consisted	consisted	NOUN
admet-341	41	4	of	of	ADP
admet-341	41	5	solution	solution	NOUN
admet-341	41	6	of	of	ADP
admet-341	41	7	anti	anti	ADJ
admet-341	41	8	-	-	ADJ
admet-341	41	9	nucleating	nucleating	ADJ
admet-341	41	10	polymer	polymer	NOUN
admet-341	41	11	and/or	and/or	CCONJ
admet-341	41	12	surfactant	surfactant	NOUN
admet-341	41	13	in	in	ADP
admet-341	41	14	distilled	distil	VERB
admet-341	41	15	water	water	NOUN
admet-341	41	16	or	or	CCONJ
admet-341	41	17	buffer	buffer	NOUN
admet-341	41	18	.	.	PUNCT
admet-341	42	1	if	if	SCONJ
admet-341	42	2	required	require	VERB
admet-341	42	3	,	,	PUNCT
admet-341	42	4	sample	sample	NOUN
admet-341	42	5	was	be	AUX
admet-341	42	6	intermittently	intermittently	ADV
admet-341	42	7	bath	bath	NOUN
admet-341	42	8	sonicated	sonicate	VERB
admet-341	42	9	and	and	CCONJ
admet-341	42	10	heated	heat	VERB
admet-341	42	11	at	at	ADP
admet-341	42	12	60	60	NUM
admet-341	42	13	-	-	SYM
admet-341	42	14	80	80	NUM
admet-341	42	15	°	°	NUM
admet-341	42	16	c	c	X
admet-341	42	17	.	.	PUNCT
admet-341	43	1	test	test	NOUN
admet-341	43	2	media	medium	NOUN
admet-341	43	3	was	be	AUX
admet-341	43	4	added	add	VERB
admet-341	43	5	either	either	CCONJ
admet-341	43	6	till	till	SCONJ
admet-341	43	7	a	a	DET
admet-341	43	8	solution	solution	NOUN
admet-341	43	9	was	be	AUX
admet-341	43	10	obtained	obtain	VERB
admet-341	43	11	or	or	CCONJ
admet-341	43	12	till	till	SCONJ
admet-341	43	13	theoretical	theoretical	ADJ
admet-341	43	14	concentration	concentration	NOUN
admet-341	43	15	was	be	AUX
admet-341	43	16	achieved	achieve	VERB
admet-341	43	17	(	(	PUNCT
admet-341	43	18	data	datum	NOUN
admet-341	43	19	not	not	PART
admet-341	43	20	shown	show	VERB
admet-341	43	21	)	)	PUNCT
admet-341	43	22	.	.	PUNCT
admet-341	44	1	the	the	DET
admet-341	44	2	final	final	ADJ
admet-341	44	3	sample	sample	NOUN
admet-341	44	4	was	be	AUX
admet-341	44	5	observed	observe	VERB
admet-341	44	6	both	both	CCONJ
admet-341	44	7	visually	visually	ADV
admet-341	44	8	and	and	CCONJ
admet-341	44	9	also	also	ADV
admet-341	44	10	by	by	ADP
admet-341	44	11	using	use	VERB
admet-341	44	12	polarized	polarize	VERB
admet-341	44	13	light	light	ADJ
admet-341	44	14	microscopy	microscopy	NOUN
admet-341	44	15	for	for	ADP
admet-341	44	16	better	well	ADJ
admet-341	44	17	clarity	clarity	NOUN
admet-341	44	18	(	(	PUNCT
admet-341	44	19	in	in	ADP
admet-341	44	20	terms	term	NOUN
admet-341	44	21	of	of	ADP
admet-341	44	22	number	number	NOUN
admet-341	44	23	of	of	ADP
admet-341	44	24	visible	visible	ADJ
admet-341	44	25	particles	particle	NOUN
admet-341	44	26	)	)	PUNCT
admet-341	44	27	.	.	PUNCT
admet-341	45	1	pharmacokinetics	pharmacokinetic	NOUN
admet-341	45	2	pharmacokinetics	pharmacokinetic	NOUN
admet-341	45	3	in	in	ADP
admet-341	45	4	rats	rat	NOUN
admet-341	45	5	male	male	ADJ
admet-341	45	6	sprague	sprague	NOUN
admet-341	45	7	dawley	dawley	NOUN
admet-341	45	8	(	(	PUNCT
admet-341	45	9	sd	sd	NOUN
admet-341	45	10	)	)	PUNCT
admet-341	45	11	rats	rat	NOUN
admet-341	45	12	weighing	weigh	VERB
admet-341	45	13	240	240	NUM
admet-341	45	14	-	-	SYM
admet-341	45	15	260	260	NUM
admet-341	45	16	g	g	NOUN
admet-341	45	17	were	be	AUX
admet-341	45	18	obtained	obtain	VERB
admet-341	45	19	from	from	ADP
admet-341	45	20	the	the	DET
admet-341	45	21	taconic	taconic	NOUN
admet-341	45	22	laboratories	laboratory	NOUN
admet-341	45	23	(	(	PUNCT
admet-341	45	24	vivo	vivo	NOUN
admet-341	45	25	biotech	biotech	NOUN
admet-341	45	26	,	,	PUNCT
admet-341	45	27	hyderabad	hyderabad	PROPN
admet-341	45	28	,	,	PUNCT
admet-341	45	29	india	india	PROPN
admet-341	45	30	)	)	PUNCT
admet-341	45	31	.	.	PUNCT
admet-341	46	1	they	they	PRON
admet-341	46	2	were	be	AUX
admet-341	46	3	housed	house	VERB
admet-341	46	4	under	under	ADP
admet-341	46	5	standard	standard	ADJ
admet-341	46	6	conditions	condition	NOUN
admet-341	46	7	and	and	CCONJ
admet-341	46	8	were	be	AUX
admet-341	46	9	maintained	maintain	VERB
admet-341	46	10	under	under	ADP
admet-341	46	11	a	a	DET
admet-341	46	12	12	12	NUM
admet-341	46	13	h	h	NOUN
admet-341	46	14	light	light	ADJ
admet-341	46	15	/	/	SYM
admet-341	46	16	dark	dark	ADJ
admet-341	46	17	cycle	cycle	NOUN
admet-341	46	18	in	in	ADP
admet-341	46	19	the	the	DET
admet-341	46	20	laboratory	laboratory	NOUN
admet-341	46	21	animal	animal	NOUN
admet-341	46	22	resources	resource	NOUN
admet-341	46	23	facilities	facility	NOUN
admet-341	46	24	,	,	PUNCT
admet-341	46	25	gvk	gvk	PROPN
admet-341	46	26	biosciences	biosciences	PROPN
admet-341	46	27	pvt	pvt	PROPN
admet-341	46	28	.	.	PROPN
admet-341	46	29	ltd	ltd	PROPN
admet-341	46	30	,	,	PUNCT
admet-341	46	31	hyderabad	hyderabad	PROPN
admet-341	46	32	,	,	PUNCT
admet-341	46	33	india	india	PROPN
admet-341	46	34	srinivas	srinivas	PROPN
admet-341	46	35	maddi	maddi	PROPN
admet-341	46	36	et	et	PROPN
admet-341	46	37	al	al	PROPN
admet-341	46	38	.	.	PROPN
admet-341	46	39	admet	admet	PROPN
admet-341	46	40	&	&	CCONJ
admet-341	46	41	dmpk	dmpk	PROPN
admet-341	46	42	4(4	4(4	NUM
admet-341	46	43	)	)	PUNCT
admet-341	46	44	(	(	PUNCT
admet-341	46	45	2016	2016	NUM
admet-341	46	46	)	)	PUNCT
admet-341	46	47	314	314	NUM
admet-341	46	48	-	-	SYM
admet-341	46	49	326	326	NUM
admet-341	46	50	316	316	NUM
admet-341	46	51	(	(	PUNCT
admet-341	46	52	aaalac	aaalac	PROPN
admet-341	46	53	accredited	accredit	VERB
admet-341	46	54	)	)	PUNCT
admet-341	46	55	.	.	PUNCT
admet-341	47	1	they	they	PRON
admet-341	47	2	were	be	AUX
admet-341	47	3	allowed	allow	VERB
admet-341	47	4	access	access	NOUN
admet-341	47	5	to	to	ADP
admet-341	47	6	commercial	commercial	ADJ
admet-341	47	7	rodent	rodent	NOUN
admet-341	47	8	chow	chow	NOUN
admet-341	47	9	and	and	CCONJ
admet-341	47	10	water	water	NOUN
admet-341	47	11	ad	ad	NOUN
admet-341	47	12	libitum	libitum	PROPN
admet-341	47	13	.	.	PUNCT
admet-341	48	1	rats	rat	NOUN
admet-341	48	2	were	be	AUX
admet-341	48	3	fasted	fast	VERB
admet-341	48	4	overnight	overnight	ADV
admet-341	48	5	before	before	ADP
admet-341	48	6	dosing	dose	VERB
admet-341	48	7	and	and	CCONJ
admet-341	48	8	then	then	ADV
admet-341	48	9	until	until	ADP
admet-341	48	10	3	3	NUM
admet-341	48	11	h	h	NOUN
admet-341	48	12	after	after	ADP
admet-341	48	13	dosing	dose	VERB
admet-341	48	14	.	.	PUNCT
admet-341	49	1	water	water	NOUN
admet-341	49	2	was	be	AUX
admet-341	49	3	allowed	allow	VERB
admet-341	49	4	ad	ad	NOUN
admet-341	49	5	libitum	libitum	NOUN
admet-341	49	6	during	during	ADP
admet-341	49	7	the	the	DET
admet-341	49	8	fasting	fast	VERB
admet-341	49	9	period	period	NOUN
admet-341	49	10	.	.	PUNCT
admet-341	50	1	rats	rat	NOUN
admet-341	50	2	were	be	AUX
admet-341	50	3	cannulated	cannulate	VERB
admet-341	50	4	at	at	ADP
admet-341	50	5	the	the	DET
admet-341	50	6	jugular	jugular	PROPN
admet-341	50	7	vein	vein	NOUN
admet-341	50	8	for	for	ADP
admet-341	50	9	serial	serial	ADJ
admet-341	50	10	bleeding	bleeding	NOUN
admet-341	50	11	.	.	PUNCT
admet-341	51	1	three	three	NUM
admet-341	51	2	male	male	ADJ
admet-341	51	3	rats	rat	NOUN
admet-341	51	4	per	per	ADP
admet-341	51	5	group	group	NOUN
admet-341	51	6	were	be	AUX
admet-341	51	7	dosed	dose	VERB
admet-341	51	8	via	via	ADP
admet-341	51	9	oral	oral	ADJ
admet-341	51	10	(	(	PUNCT
admet-341	51	11	po	po	NOUN
admet-341	51	12	,	,	PUNCT
admet-341	51	13	5	5	NUM
admet-341	51	14	mg	mg	NUM
admet-341	51	15	/	/	SYM
admet-341	51	16	kg	kg	NOUN
admet-341	51	17	)	)	PUNCT
admet-341	51	18	and	and	CCONJ
admet-341	51	19	intravenous	intravenous	ADJ
admet-341	51	20	(	(	PUNCT
admet-341	51	21	iv	iv	NUM
admet-341	51	22	,	,	PUNCT
admet-341	51	23	1	1	NUM
admet-341	51	24	mg	mg	NUM
admet-341	51	25	/	/	SYM
admet-341	51	26	kg	kg	NOUN
admet-341	51	27	)	)	PUNCT
admet-341	51	28	routes	route	NOUN
admet-341	51	29	for	for	ADP
admet-341	51	30	the	the	DET
admet-341	51	31	determination	determination	NOUN
admet-341	51	32	of	of	ADP
admet-341	51	33	pharmacokinetics	pharmacokinetic	NOUN
admet-341	51	34	of	of	ADP
admet-341	51	35	gbo-006	gbo-006	NOUN
admet-341	51	36	.	.	PUNCT
admet-341	52	1	after	after	ADP
admet-341	52	2	dosing	dose	VERB
admet-341	52	3	,	,	PUNCT
admet-341	52	4	0.3	0.3	NUM
admet-341	52	5	ml	ml	NOUN
admet-341	52	6	specimens	specimen	NOUN
admet-341	52	7	of	of	ADP
admet-341	52	8	blood	blood	NOUN
admet-341	52	9	were	be	AUX
admet-341	52	10	collected	collect	VERB
admet-341	52	11	by	by	ADP
admet-341	52	12	serial	serial	ADJ
admet-341	52	13	sampling	sampling	NOUN
admet-341	52	14	from	from	ADP
admet-341	52	15	the	the	DET
admet-341	52	16	jugular	jugular	ADJ
admet-341	52	17	cannula	cannula	NOUN
admet-341	52	18	at	at	ADP
admet-341	52	19	0.25	0.25	NUM
admet-341	52	20	,	,	PUNCT
admet-341	52	21	0.5	0.5	NUM
admet-341	52	22	,	,	PUNCT
admet-341	52	23	1	1	NUM
admet-341	52	24	,	,	PUNCT
admet-341	52	25	2	2	NUM
admet-341	52	26	,	,	PUNCT
admet-341	52	27	4	4	NUM
admet-341	52	28	,	,	PUNCT
admet-341	52	29	8	8	NUM
admet-341	52	30	and	and	CCONJ
admet-341	52	31	24	24	NUM
admet-341	52	32	h	h	NOUN
admet-341	52	33	after	after	ADP
admet-341	52	34	po	po	NOUN
admet-341	52	35	,	,	PUNCT
admet-341	52	36	and	and	CCONJ
admet-341	52	37	0.08	0.08	NUM
admet-341	52	38	,	,	PUNCT
admet-341	52	39	0.25	0.25	NUM
admet-341	52	40	,	,	PUNCT
admet-341	52	41	0.5	0.5	NUM
admet-341	52	42	,	,	PUNCT
admet-341	52	43	1	1	NUM
admet-341	52	44	,	,	PUNCT
admet-341	52	45	2	2	NUM
admet-341	52	46	,	,	PUNCT
admet-341	52	47	4	4	NUM
admet-341	52	48	,	,	PUNCT
admet-341	52	49	8	8	NUM
admet-341	52	50	,	,	PUNCT
admet-341	52	51	24	24	NUM
admet-341	52	52	h	h	NOUN
admet-341	52	53	after	after	ADP
admet-341	52	54	iv	iv	NUM
admet-341	52	55	route	route	NOUN
admet-341	52	56	,	,	PUNCT
admet-341	52	57	respectively	respectively	ADV
admet-341	52	58	.	.	PUNCT
admet-341	53	1	after	after	ADP
admet-341	53	2	collection	collection	NOUN
admet-341	53	3	,	,	PUNCT
admet-341	53	4	blood	blood	NOUN
admet-341	53	5	was	be	AUX
admet-341	53	6	processed	process	VERB
admet-341	53	7	to	to	AUX
admet-341	53	8	plasma	plasma	VERB
admet-341	53	9	by	by	ADP
admet-341	53	10	centrifugation	centrifugation	NOUN
admet-341	53	11	at	at	ADP
admet-341	53	12	10000	10000	NUM
admet-341	53	13	rpm	rpm	NOUN
admet-341	53	14	for	for	ADP
admet-341	53	15	5	5	NUM
admet-341	53	16	min	min	NOUN
admet-341	53	17	,	,	PUNCT
admet-341	53	18	and	and	CCONJ
admet-341	53	19	samples	sample	NOUN
admet-341	53	20	were	be	AUX
admet-341	53	21	analyzed	analyze	VERB
admet-341	53	22	by	by	ADP
admet-341	53	23	lc	lc	PROPN
admet-341	53	24	-	-	PUNCT
admet-341	53	25	ms	ms	PROPN
admet-341	53	26	/	/	SYM
admet-341	53	27	ms	ms	PROPN
admet-341	53	28	.	.	PROPN
admet-341	53	29	pharmacokinetics	pharmacokinetic	NOUN
admet-341	53	30	in	in	ADP
admet-341	53	31	mice	mouse	NOUN
admet-341	53	32	swiss	swiss	ADJ
admet-341	53	33	albino	albino	NOUN
admet-341	53	34	mice	mouse	NOUN
admet-341	53	35	were	be	AUX
admet-341	53	36	obtained	obtain	VERB
admet-341	53	37	from	from	ADP
admet-341	53	38	taconic	taconic	NOUN
admet-341	53	39	laboratories	laboratory	NOUN
admet-341	53	40	(	(	PUNCT
admet-341	53	41	vivo	vivo	NOUN
admet-341	53	42	biotech	biotech	NOUN
admet-341	53	43	,	,	PUNCT
admet-341	53	44	hyderabad	hyderabad	PROPN
admet-341	53	45	,	,	PUNCT
admet-341	53	46	india	india	PROPN
admet-341	53	47	)	)	PUNCT
admet-341	53	48	.	.	PUNCT
admet-341	54	1	they	they	PRON
admet-341	54	2	were	be	AUX
admet-341	54	3	housed	house	VERB
admet-341	54	4	under	under	ADP
admet-341	54	5	standard	standard	ADJ
admet-341	54	6	conditions	condition	NOUN
admet-341	54	7	and	and	CCONJ
admet-341	54	8	were	be	AUX
admet-341	54	9	maintained	maintain	VERB
admet-341	54	10	under	under	ADP
admet-341	54	11	a	a	DET
admet-341	54	12	12	12	NUM
admet-341	54	13	h	h	NOUN
admet-341	54	14	light	light	ADJ
admet-341	54	15	/	/	SYM
admet-341	54	16	dark	dark	ADJ
admet-341	54	17	cycle	cycle	NOUN
admet-341	54	18	in	in	ADP
admet-341	54	19	the	the	DET
admet-341	54	20	laboratory	laboratory	NOUN
admet-341	54	21	animal	animal	NOUN
admet-341	54	22	resources	resource	NOUN
admet-341	54	23	facilities	facility	NOUN
admet-341	54	24	,	,	PUNCT
admet-341	54	25	gvk	gvk	PROPN
admet-341	54	26	biosciences	biosciences	PROPN
admet-341	54	27	pvt	pvt	PROPN
admet-341	54	28	.	.	PROPN
admet-341	54	29	ltd	ltd	PROPN
admet-341	54	30	,	,	PUNCT
admet-341	54	31	hyderabad	hyderabad	PROPN
admet-341	54	32	,	,	PUNCT
admet-341	54	33	india	india	PROPN
admet-341	55	1	(	(	PUNCT
admet-341	55	2	aaalac	aaalac	PROPN
admet-341	55	3	accredited	accredit	VERB
admet-341	55	4	)	)	PUNCT
admet-341	55	5	.	.	PUNCT
admet-341	56	1	they	they	PRON
admet-341	56	2	were	be	AUX
admet-341	56	3	allowed	allow	VERB
admet-341	56	4	access	access	NOUN
admet-341	56	5	to	to	ADP
admet-341	56	6	commercial	commercial	ADJ
admet-341	56	7	rodent	rodent	NOUN
admet-341	56	8	chow	chow	NOUN
admet-341	56	9	and	and	CCONJ
admet-341	56	10	water	water	NOUN
admet-341	56	11	ad	ad	NOUN
admet-341	56	12	libitum	libitum	X
admet-341	56	13	.	.	PUNCT
admet-341	57	1	mice	mouse	NOUN
admet-341	57	2	were	be	AUX
admet-341	57	3	fasted	fast	VERB
admet-341	57	4	overnight	overnight	ADV
admet-341	57	5	before	before	ADP
admet-341	57	6	dosing	dose	VERB
admet-341	57	7	and	and	CCONJ
admet-341	57	8	then	then	ADV
admet-341	57	9	until	until	ADP
admet-341	57	10	3	3	NUM
admet-341	57	11	h	h	NOUN
admet-341	57	12	after	after	ADP
admet-341	57	13	dosing	dose	VERB
admet-341	57	14	.	.	PUNCT
admet-341	58	1	water	water	NOUN
admet-341	58	2	was	be	AUX
admet-341	58	3	allowed	allow	VERB
admet-341	58	4	ad	ad	NOUN
admet-341	58	5	libitum	libitum	NOUN
admet-341	58	6	during	during	ADP
admet-341	58	7	the	the	DET
admet-341	58	8	fasting	fasting	NOUN
admet-341	58	9	period	period	NOUN
admet-341	58	10	.	.	PUNCT
admet-341	59	1	the	the	DET
admet-341	59	2	bodyweights	bodyweight	NOUN
admet-341	59	3	of	of	ADP
admet-341	59	4	individual	individual	ADJ
admet-341	59	5	mice	mouse	NOUN
admet-341	59	6	,	,	PUNCT
admet-341	59	7	ranging	range	VERB
admet-341	59	8	from	from	ADP
admet-341	59	9	25	25	NUM
admet-341	59	10	to	to	PART
admet-341	59	11	30	30	NUM
admet-341	59	12	g	g	NOUN
admet-341	59	13	,	,	PUNCT
admet-341	59	14	were	be	AUX
admet-341	59	15	determined	determine	VERB
admet-341	59	16	on	on	ADP
admet-341	59	17	the	the	DET
admet-341	59	18	morning	morning	NOUN
admet-341	59	19	of	of	ADP
admet-341	59	20	the	the	DET
admet-341	59	21	study	study	NOUN
admet-341	59	22	.	.	PUNCT
admet-341	60	1	nine	nine	NUM
admet-341	60	2	mice	mouse	NOUN
admet-341	60	3	for	for	ADP
admet-341	60	4	oral	oral	ADJ
admet-341	60	5	route	route	NOUN
admet-341	60	6	and	and	CCONJ
admet-341	60	7	twelve	twelve	NUM
admet-341	60	8	mice	mouse	NOUN
admet-341	60	9	for	for	ADP
admet-341	60	10	i.v	i.v	PROPN
admet-341	60	11	.	.	PUNCT
admet-341	60	12	route	route	PROPN
admet-341	60	13	were	be	AUX
admet-341	60	14	dosed	dose	VERB
admet-341	60	15	.	.	PUNCT
admet-341	61	1	after	after	ADP
admet-341	61	2	dosing	dose	VERB
admet-341	61	3	,	,	PUNCT
admet-341	61	4	0.1	0.1	NUM
admet-341	61	5	ml	ml	ADP
admet-341	61	6	specimens	specimen	NOUN
admet-341	61	7	of	of	ADP
admet-341	61	8	blood	blood	NOUN
admet-341	61	9	were	be	AUX
admet-341	61	10	collected	collect	VERB
admet-341	61	11	by	by	ADP
admet-341	61	12	stagger	stagger	NOUN
admet-341	61	13	sampling	sampling	NOUN
admet-341	61	14	with	with	ADP
admet-341	61	15	two	two	NUM
admet-341	61	16	bleeds	bleed	NOUN
admet-341	61	17	per	per	ADP
admet-341	61	18	mouse	mouse	NOUN
admet-341	61	19	from	from	ADP
admet-341	61	20	the	the	DET
admet-341	61	21	retro	retro	ADJ
admet-341	61	22	orbital	orbital	ADJ
admet-341	61	23	plexus	plexus	NOUN
admet-341	61	24	at	at	ADP
admet-341	61	25	0.5	0.5	NUM
admet-341	61	26	,	,	PUNCT
admet-341	61	27	1	1	NUM
admet-341	61	28	,	,	PUNCT
admet-341	61	29	2	2	NUM
admet-341	61	30	,	,	PUNCT
admet-341	61	31	4	4	NUM
admet-341	61	32	,	,	PUNCT
admet-341	61	33	8	8	NUM
admet-341	61	34	,	,	PUNCT
admet-341	61	35	24	24	NUM
admet-341	61	36	h	h	NOUN
admet-341	61	37	after	after	ADP
admet-341	61	38	po	po	PROPN
admet-341	61	39	route	route	NOUN
admet-341	61	40	and	and	CCONJ
admet-341	61	41	0.08	0.08	NUM
admet-341	61	42	,	,	PUNCT
admet-341	61	43	0.25	0.25	NUM
admet-341	61	44	,	,	PUNCT
admet-341	61	45	0.5	0.5	NUM
admet-341	61	46	,	,	PUNCT
admet-341	61	47	1	1	NUM
admet-341	61	48	,	,	PUNCT
admet-341	61	49	2	2	NUM
admet-341	61	50	,	,	PUNCT
admet-341	61	51	4	4	NUM
admet-341	61	52	,	,	PUNCT
admet-341	61	53	8	8	NUM
admet-341	61	54	,	,	PUNCT
admet-341	61	55	24	24	NUM
admet-341	61	56	h	h	NOUN
admet-341	61	57	after	after	ADP
admet-341	61	58	iv	iv	NUM
admet-341	61	59	route	route	NOUN
admet-341	61	60	respectively	respectively	ADV
admet-341	61	61	.	.	PUNCT
admet-341	62	1	after	after	ADP
admet-341	62	2	collection	collection	NOUN
admet-341	62	3	,	,	PUNCT
admet-341	62	4	blood	blood	NOUN
admet-341	62	5	was	be	AUX
admet-341	62	6	processed	process	VERB
admet-341	62	7	to	to	AUX
admet-341	62	8	plasma	plasma	VERB
admet-341	62	9	by	by	ADP
admet-341	62	10	centrifugation	centrifugation	NOUN
admet-341	62	11	at	at	ADP
admet-341	62	12	10000	10000	NUM
admet-341	62	13	rpm	rpm	NOUN
admet-341	62	14	for	for	ADP
admet-341	62	15	5	5	NUM
admet-341	62	16	min	min	NOUN
admet-341	62	17	,	,	PUNCT
admet-341	62	18	and	and	CCONJ
admet-341	62	19	samples	sample	NOUN
admet-341	62	20	were	be	AUX
admet-341	62	21	analyzed	analyze	VERB
admet-341	62	22	by	by	ADP
admet-341	62	23	lc	lc	PROPN
admet-341	62	24	-	-	PUNCT
admet-341	62	25	ms	ms	PROPN
admet-341	62	26	/	/	SYM
admet-341	62	27	ms	ms	PROPN
admet-341	62	28	.	.	PROPN
admet-341	62	29	dose	dose	PROPN
admet-341	62	30	dependent	dependent	ADJ
admet-341	62	31	intraperitoneal	intraperitoneal	ADJ
admet-341	62	32	pharmacokinetics	pharmacokinetic	NOUN
admet-341	62	33	in	in	ADP
admet-341	62	34	mice	mouse	NOUN
admet-341	62	35	gbo-006	gbo-006	NOUN
admet-341	62	36	was	be	AUX
admet-341	62	37	administered	administer	VERB
admet-341	62	38	in	in	ADP
admet-341	62	39	mice	mouse	NOUN
admet-341	62	40	via	via	ADP
admet-341	62	41	ip	ip	ADJ
admet-341	62	42	route	route	NOUN
admet-341	62	43	at	at	ADP
admet-341	62	44	10	10	NUM
admet-341	62	45	,	,	PUNCT
admet-341	62	46	30	30	NUM
admet-341	62	47	,	,	PUNCT
admet-341	62	48	75	75	NUM
admet-341	62	49	and	and	CCONJ
admet-341	62	50	100	100	NUM
admet-341	62	51	mg	mg	NUM
admet-341	62	52	/	/	SYM
admet-341	62	53	kg	kg	PROPN
admet-341	62	54	dose	dose	VERB
admet-341	62	55	to	to	PART
admet-341	62	56	understand	understand	VERB
admet-341	62	57	the	the	DET
admet-341	62	58	dose	dose	ADJ
admet-341	62	59	dependent	dependent	ADJ
admet-341	62	60	exposure	exposure	NOUN
admet-341	62	61	.	.	PUNCT
admet-341	63	1	after	after	ADP
admet-341	63	2	dosing	dose	VERB
admet-341	63	3	,	,	PUNCT
admet-341	63	4	0.3	0.3	NUM
admet-341	63	5	ml	ml	NOUN
admet-341	63	6	specimens	specimen	NOUN
admet-341	63	7	of	of	ADP
admet-341	63	8	blood	blood	NOUN
admet-341	63	9	were	be	AUX
admet-341	63	10	collected	collect	VERB
admet-341	63	11	by	by	ADP
admet-341	63	12	stagger	stagger	NOUN
admet-341	63	13	sampling	sampling	NOUN
admet-341	63	14	with	with	ADP
admet-341	63	15	two	two	NUM
admet-341	63	16	bleeds	bleed	NOUN
admet-341	63	17	per	per	ADP
admet-341	63	18	mouse	mouse	NOUN
admet-341	63	19	from	from	ADP
admet-341	63	20	the	the	DET
admet-341	63	21	retro	retro	ADJ
admet-341	63	22	orbital	orbital	ADJ
admet-341	63	23	plexus	plexus	NOUN
admet-341	63	24	at	at	ADP
admet-341	63	25	0.5	0.5	NUM
admet-341	63	26	,	,	PUNCT
admet-341	63	27	1	1	NUM
admet-341	63	28	,	,	PUNCT
admet-341	63	29	2	2	NUM
admet-341	63	30	,	,	PUNCT
admet-341	63	31	4	4	NUM
admet-341	63	32	,	,	PUNCT
admet-341	63	33	8	8	NUM
admet-341	63	34	,	,	PUNCT
admet-341	63	35	24	24	NUM
admet-341	63	36	h.	h.	NOUN
admet-341	63	37	blood	blood	NOUN
admet-341	63	38	was	be	AUX
admet-341	63	39	processed	process	VERB
admet-341	63	40	for	for	ADP
admet-341	63	41	plasma	plasma	NOUN
admet-341	63	42	collection	collection	NOUN
admet-341	63	43	by	by	ADP
admet-341	63	44	the	the	DET
admet-341	63	45	process	process	NOUN
admet-341	63	46	mentioned	mention	VERB
admet-341	63	47	in	in	ADP
admet-341	63	48	the	the	DET
admet-341	63	49	above	above	ADJ
admet-341	63	50	pharmacokinetics	pharmacokinetic	NOUN
admet-341	63	51	section	section	NOUN
admet-341	63	52	.	.	PUNCT
admet-341	64	1	pharmacokinetics	pharmacokinetic	NOUN
admet-341	64	2	in	in	ADP
admet-341	64	3	dogs	dog	NOUN
admet-341	64	4	dog	dog	NOUN
admet-341	64	5	studies	study	NOUN
admet-341	64	6	were	be	AUX
admet-341	64	7	performed	perform	VERB
admet-341	64	8	at	at	ADP
admet-341	64	9	palamur	palamur	NOUN
admet-341	64	10	biosciences	bioscience	NOUN
admet-341	64	11	pvt	pvt	PROPN
admet-341	64	12	.	.	PROPN
admet-341	64	13	ltd	ltd	PROPN
admet-341	65	1	(	(	PUNCT
admet-341	65	2	hyderabad	hyderabad	PROPN
admet-341	65	3	,	,	PUNCT
admet-341	65	4	india	india	PROPN
admet-341	65	5	)	)	PUNCT
admet-341	65	6	.	.	PUNCT
admet-341	66	1	six	six	NUM
admet-341	66	2	male	male	ADJ
admet-341	66	3	beagle	beagle	NOUN
admet-341	66	4	dogs	dog	NOUN
admet-341	66	5	were	be	AUX
admet-341	66	6	housed	house	VERB
admet-341	66	7	under	under	ADP
admet-341	66	8	standard	standard	ADJ
admet-341	66	9	conditions	condition	NOUN
admet-341	66	10	and	and	CCONJ
admet-341	66	11	were	be	AUX
admet-341	66	12	maintained	maintain	VERB
admet-341	66	13	under	under	ADP
admet-341	66	14	a	a	DET
admet-341	66	15	12	12	NUM
admet-341	66	16	h	h	NOUN
admet-341	66	17	light	light	ADJ
admet-341	66	18	/	/	SYM
admet-341	66	19	dark	dark	ADJ
admet-341	66	20	cycle	cycle	NOUN
admet-341	66	21	in	in	ADP
admet-341	66	22	the	the	DET
admet-341	66	23	laboratory	laboratory	NOUN
admet-341	66	24	animal	animal	NOUN
admet-341	66	25	resources	resource	NOUN
admet-341	66	26	facilities	facility	NOUN
admet-341	66	27	.	.	PUNCT
admet-341	67	1	they	they	PRON
admet-341	67	2	were	be	AUX
admet-341	67	3	allowed	allow	VERB
admet-341	67	4	access	access	NOUN
admet-341	67	5	to	to	ADP
admet-341	67	6	water	water	NOUN
admet-341	67	7	ad	ad	NOUN
admet-341	67	8	libitum	libitum	X
admet-341	67	9	.	.	PUNCT
admet-341	68	1	dogs	dog	NOUN
admet-341	68	2	were	be	AUX
admet-341	68	3	fasted	fast	VERB
admet-341	68	4	overnight	overnight	ADV
admet-341	68	5	before	before	ADP
admet-341	68	6	po	po	NOUN
admet-341	68	7	dosing	dosing	NOUN
admet-341	68	8	and	and	CCONJ
admet-341	68	9	then	then	ADV
admet-341	68	10	until	until	ADP
admet-341	68	11	4	4	NUM
admet-341	68	12	h	h	NOUN
admet-341	68	13	after	after	ADP
admet-341	68	14	dosing	dose	VERB
admet-341	68	15	.	.	PUNCT
admet-341	69	1	water	water	NOUN
admet-341	69	2	was	be	AUX
admet-341	69	3	allowed	allow	VERB
admet-341	69	4	during	during	ADP
admet-341	69	5	the	the	DET
admet-341	69	6	fasting	fasting	NOUN
admet-341	69	7	period	period	NOUN
admet-341	69	8	.	.	PUNCT
admet-341	70	1	the	the	DET
admet-341	70	2	body	body	NOUN
admet-341	70	3	weight	weight	NOUN
admet-341	70	4	of	of	ADP
admet-341	70	5	the	the	DET
admet-341	70	6	individual	individual	ADJ
admet-341	70	7	dogs	dog	NOUN
admet-341	70	8	ranged	range	VERB
admet-341	70	9	from	from	ADP
admet-341	70	10	9.6	9.6	NUM
admet-341	70	11	to	to	ADP
admet-341	70	12	14.3	14.3	NUM
admet-341	70	13	kg	kg	NOUN
admet-341	70	14	.	.	PUNCT
admet-341	71	1	three	three	NUM
admet-341	71	2	male	male	ADJ
admet-341	71	3	dogs	dog	NOUN
admet-341	71	4	per	per	ADP
admet-341	71	5	group	group	NOUN
admet-341	71	6	were	be	AUX
admet-341	71	7	dosed	dose	VERB
admet-341	71	8	per	per	ADP
admet-341	71	9	oral	oral	ADJ
admet-341	71	10	(	(	PUNCT
admet-341	71	11	po	po	NOUN
admet-341	71	12	)	)	PUNCT
admet-341	71	13	,	,	PUNCT
admet-341	71	14	intravenous	intravenous	ADJ
admet-341	71	15	(	(	PUNCT
admet-341	71	16	iv	iv	X
admet-341	71	17	)	)	PUNCT
admet-341	71	18	at	at	ADP
admet-341	71	19	5	5	NUM
admet-341	71	20	and	and	CCONJ
admet-341	71	21	1	1	NUM
admet-341	71	22	mg	mg	PROPN
admet-341	71	23	/	/	SYM
admet-341	71	24	kg	kg	PROPN
admet-341	71	25	for	for	ADP
admet-341	71	26	the	the	DET
admet-341	71	27	determination	determination	NOUN
admet-341	71	28	of	of	ADP
admet-341	71	29	pharmacokinetics	pharmacokinetic	NOUN
admet-341	71	30	of	of	ADP
admet-341	71	31	gbo-006	gbo-006	NOUN
admet-341	71	32	.	.	PUNCT
admet-341	72	1	after	after	ADP
admet-341	72	2	dosing	dose	VERB
admet-341	72	3	,	,	PUNCT
admet-341	72	4	0.3	0.3	NUM
admet-341	72	5	ml	ml	NOUN
admet-341	72	6	specimens	specimen	NOUN
admet-341	72	7	of	of	ADP
admet-341	72	8	blood	blood	NOUN
admet-341	72	9	were	be	AUX
admet-341	72	10	collected	collect	VERB
admet-341	72	11	by	by	ADP
admet-341	72	12	serial	serial	ADJ
admet-341	72	13	sampling	sampling	NOUN
admet-341	72	14	from	from	ADP
admet-341	72	15	the	the	DET
admet-341	72	16	saphenous	saphenous	ADJ
admet-341	72	17	vein	vein	NOUN
admet-341	72	18	at	at	ADP
admet-341	72	19	0.167	0.167	NUM
admet-341	72	20	,	,	PUNCT
admet-341	72	21	0.5,1	0.5,1	NOUN
admet-341	72	22	,	,	PUNCT
admet-341	72	23	2	2	NUM
admet-341	72	24	,	,	PUNCT
admet-341	72	25	4	4	NUM
admet-341	72	26	,	,	PUNCT
admet-341	72	27	8	8	NUM
admet-341	72	28	,	,	PUNCT
admet-341	72	29	12	12	NUM
admet-341	72	30	,	,	PUNCT
admet-341	72	31	24	24	NUM
admet-341	72	32	h	h	NOUN
admet-341	72	33	after	after	ADP
admet-341	72	34	po	po	PROPN
admet-341	72	35	route	route	NOUN
admet-341	72	36	and	and	CCONJ
admet-341	72	37	0.033	0.033	NUM
admet-341	72	38	,	,	PUNCT
admet-341	72	39	0.167	0.167	NUM
admet-341	72	40	,	,	PUNCT
admet-341	72	41	0.5,1	0.5,1	NOUN
admet-341	72	42	,	,	PUNCT
admet-341	72	43	2	2	NUM
admet-341	72	44	,	,	PUNCT
admet-341	72	45	4	4	NUM
admet-341	72	46	,	,	PUNCT
admet-341	72	47	8	8	NUM
admet-341	72	48	,	,	PUNCT
admet-341	72	49	12	12	NUM
admet-341	72	50	,	,	PUNCT
admet-341	72	51	24	24	NUM
admet-341	72	52	h	h	NOUN
admet-341	72	53	after	after	ADP
admet-341	72	54	iv	iv	NUM
admet-341	72	55	route	route	NOUN
admet-341	72	56	,	,	PUNCT
admet-341	72	57	respectively	respectively	ADV
admet-341	72	58	.	.	PUNCT
admet-341	73	1	after	after	ADP
admet-341	73	2	collection	collection	NOUN
admet-341	73	3	,	,	PUNCT
admet-341	73	4	blood	blood	NOUN
admet-341	73	5	was	be	AUX
admet-341	73	6	processed	process	VERB
admet-341	73	7	to	to	AUX
admet-341	73	8	plasma	plasma	VERB
admet-341	73	9	by	by	ADP
admet-341	73	10	centrifugation	centrifugation	NOUN
admet-341	73	11	at	at	ADP
admet-341	73	12	10000	10000	NUM
admet-341	73	13	rpm	rpm	NOUN
admet-341	73	14	for	for	ADP
admet-341	73	15	5	5	NUM
admet-341	73	16	min	min	NOUN
admet-341	73	17	,	,	PUNCT
admet-341	73	18	and	and	CCONJ
admet-341	73	19	samples	sample	NOUN
admet-341	73	20	were	be	AUX
admet-341	73	21	analyzed	analyze	VERB
admet-341	73	22	by	by	ADP
admet-341	73	23	lc	lc	PROPN
admet-341	73	24	-	-	PUNCT
admet-341	73	25	ms	ms	PROPN
admet-341	73	26	/	/	SYM
admet-341	73	27	ms	ms	PROPN
admet-341	73	28	.	.	PROPN
admet-341	73	29	liquid	liquid	PROPN
admet-341	73	30	chromatography	chromatography	NOUN
admet-341	73	31	mass	mass	NOUN
admet-341	73	32	spectrometry	spectrometry	NOUN
admet-341	73	33	analysis	analysis	NOUN
admet-341	73	34	in	in	ADP
admet-341	73	35	vivo	vivo	ADJ
admet-341	73	36	samples	sample	NOUN
admet-341	73	37	were	be	AUX
admet-341	73	38	prepared	prepare	VERB
admet-341	73	39	by	by	ADP
admet-341	73	40	protein	protein	NOUN
admet-341	73	41	precipitation	precipitation	NOUN
admet-341	73	42	with	with	ADP
admet-341	73	43	the	the	DET
admet-341	73	44	addition	addition	NOUN
admet-341	73	45	of	of	ADP
admet-341	73	46	200	200	NUM
admet-341	73	47	µl	µl	ADP
admet-341	73	48	acetonitrile	acetonitrile	NOUN
admet-341	73	49	containing	contain	VERB
admet-341	73	50	internal	internal	ADJ
admet-341	73	51	standard	standard	NOUN
admet-341	73	52	(	(	PUNCT
admet-341	73	53	telmisartan	telmisartan	NOUN
admet-341	73	54	;	;	PUNCT
admet-341	73	55	200ng	200ng	PROPN
admet-341	73	56	/	/	SYM
admet-341	73	57	ml	ml	NOUN
admet-341	73	58	)	)	PUNCT
admet-341	73	59	to	to	ADP
admet-341	73	60	25	25	NUM
admet-341	73	61	µl	µl	ADP
admet-341	73	62	sample	sample	NOUN
admet-341	73	63	volume	volume	NOUN
admet-341	73	64	.	.	PUNCT
admet-341	74	1	samples	sample	NOUN
admet-341	74	2	were	be	AUX
admet-341	74	3	vortexed	vortexe	VERB
admet-341	74	4	and	and	CCONJ
admet-341	74	5	centrifuged	centrifuge	VERB
admet-341	74	6	at	at	ADP
admet-341	74	7	4000	4000	NUM
admet-341	74	8	rpm	rpm	NOUN
admet-341	74	9	for	for	ADP
admet-341	74	10	10	10	NUM
admet-341	74	11	min	min	NOUN
admet-341	74	12	.	.	PROPN
admet-341	75	1	then	then	ADV
admet-341	75	2	100	100	NUM
admet-341	75	3	µl	µl	NOUN
admet-341	75	4	of	of	ADP
admet-341	75	5	supernatant	supernatant	NOUN
admet-341	75	6	was	be	AUX
admet-341	75	7	diluted	dilute	VERB
admet-341	75	8	with	with	ADP
admet-341	75	9	100	100	NUM
admet-341	75	10	µl	µl	NOUN
admet-341	75	11	of	of	ADP
admet-341	75	12	methanol	methanol	NOUN
admet-341	75	13	:	:	PUNCT
admet-341	75	14	water	water	NOUN
admet-341	75	15	mixture	mixture	NOUN
admet-341	75	16	vortexed	vortexe	VERB
admet-341	75	17	and	and	CCONJ
admet-341	75	18	injected	inject	VERB
admet-341	75	19	for	for	ADP
admet-341	75	20	analysis	analysis	NOUN
admet-341	75	21	.	.	PUNCT
admet-341	76	1	standard	standard	ADJ
admet-341	76	2	and	and	CCONJ
admet-341	76	3	quality	quality	NOUN
admet-341	76	4	control	control	NOUN
admet-341	76	5	samples	sample	NOUN
admet-341	76	6	were	be	AUX
admet-341	76	7	prepared	prepare	VERB
admet-341	76	8	by	by	ADP
admet-341	76	9	adding	add	VERB
admet-341	76	10	1	1	NUM
admet-341	76	11	µl	µl	NOUN
admet-341	76	12	of	of	ADP
admet-341	76	13	aqueous	aqueous	ADJ
admet-341	76	14	known	know	VERB
admet-341	76	15	standard	standard	ADJ
admet-341	76	16	/	/	SYM
admet-341	76	17	quality	quality	NOUN
admet-341	76	18	control	control	NOUN
admet-341	76	19	samples	sample	NOUN
admet-341	76	20	to	to	ADP
admet-341	76	21	24	24	NUM
admet-341	76	22	µl	µl	ADP
admet-341	76	23	of	of	ADP
admet-341	76	24	blank	blank	ADJ
admet-341	76	25	plasma	plasma	NOUN
admet-341	76	26	and	and	CCONJ
admet-341	76	27	processed	process	VERB
admet-341	76	28	as	as	SCONJ
admet-341	76	29	mentioned	mention	VERB
admet-341	76	30	above	above	ADV
admet-341	76	31	.	.	PUNCT
admet-341	77	1	the	the	DET
admet-341	77	2	selected	select	VERB
admet-341	77	3	[	[	X
admet-341	77	4	m+h]+	m+h]+	NOUN
admet-341	77	5	and	and	CCONJ
admet-341	77	6	product	product	NOUN
admet-341	77	7	ions	ion	NOUN
admet-341	77	8	monitored	monitor	VERB
admet-341	77	9	were	be	AUX
admet-341	77	10	m	m	PROPN
admet-341	77	11	/	/	SYM
admet-341	77	12	z	z	PROPN
admet-341	77	13	468.2	468.2	NUM
admet-341	77	14	,	,	PUNCT
admet-341	77	15	290.2	290.2	NUM
admet-341	77	16	for	for	ADP
admet-341	77	17	gbo-006	gbo-006	NOUN
admet-341	77	18	admet	admet	PROPN
admet-341	77	19	&	&	CCONJ
admet-341	77	20	dmpk	dmpk	PROPN
admet-341	77	21	4(4	4(4	NUM
admet-341	77	22	)	)	PUNCT
admet-341	77	23	(	(	PUNCT
admet-341	77	24	2016	2016	NUM
admet-341	77	25	)	)	PUNCT
admet-341	77	26	314	314	NUM
admet-341	77	27	-	-	SYM
admet-341	77	28	326	326	NUM
admet-341	77	29	pharmacokinetics	pharmacokinetic	NOUN
admet-341	77	30	and	and	CCONJ
admet-341	77	31	efficacy	efficacy	NOUN
admet-341	77	32	of	of	ADP
admet-341	77	33	plk2	plk2	PROPN
admet-341	77	34	inhibitor	inhibitor	NOUN
admet-341	77	35	doi	doi	PROPN
admet-341	77	36	:	:	PUNCT
admet-341	77	37	10.5599	10.5599	NUM
admet-341	77	38	/	/	SYM
admet-341	77	39	admet.4.4.341	admet.4.4.341	NOUN
admet-341	77	40	317	317	NUM
admet-341	77	41	(	(	PUNCT
admet-341	77	42	figure	figure	NOUN
admet-341	77	43	1	1	NUM
admet-341	77	44	)	)	PUNCT
admet-341	77	45	and	and	CCONJ
admet-341	77	46	m	m	PROPN
admet-341	77	47	/	/	SYM
admet-341	77	48	z	z	PROPN
admet-341	77	49	515.3	515.3	NUM
admet-341	77	50	,	,	PUNCT
admet-341	77	51	276.1	276.1	NUM
admet-341	77	52	for	for	ADP
admet-341	77	53	telmisartan	telmisartan	NOUN
admet-341	77	54	,	,	PUNCT
admet-341	77	55	respectively	respectively	ADV
admet-341	77	56	.	.	PUNCT
admet-341	78	1	the	the	DET
admet-341	78	2	high	high	ADJ
admet-341	78	3	-	-	PUNCT
admet-341	78	4	performance	performance	NOUN
admet-341	78	5	liquid	liquid	ADJ
admet-341	78	6	chromatography	chromatography	NOUN
admet-341	78	7	column	column	NOUN
admet-341	78	8	was	be	AUX
admet-341	78	9	a	a	DET
admet-341	78	10	c18	c18	NOUN
admet-341	78	11	-	-	PUNCT
admet-341	78	12	xbridge	xbridge	NOUN
admet-341	78	13	column	column	NOUN
admet-341	78	14	(	(	PUNCT
admet-341	78	15	4.6x50	4.6x50	NUM
admet-341	78	16	mm	mm	NOUN
admet-341	78	17	,	,	PUNCT
admet-341	78	18	3.5	3.5	NUM
admet-341	78	19	µm	µm	NOUN
admet-341	78	20	)	)	PUNCT
admet-341	78	21	maintained	maintain	VERB
admet-341	78	22	at	at	ADP
admet-341	78	23	400	400	NUM
admet-341	78	24	c	c	NOUN
admet-341	78	25	with	with	ADP
admet-341	78	26	a	a	DET
admet-341	78	27	flow	flow	NOUN
admet-341	78	28	rate	rate	NOUN
admet-341	78	29	of	of	ADP
admet-341	78	30	1.0	1.0	NUM
admet-341	78	31	ml	ml	NOUN
admet-341	78	32	/	/	SYM
admet-341	78	33	min	min	NOUN
admet-341	78	34	with	with	ADP
admet-341	78	35	the	the	DET
admet-341	78	36	split	split	ADJ
admet-341	78	37	ratio	ratio	NOUN
admet-341	78	38	of	of	ADP
admet-341	78	39	60:40	60:40	NUM
admet-341	78	40	.	.	PUNCT
admet-341	79	1	the	the	DET
admet-341	79	2	mobile	mobile	ADJ
admet-341	79	3	phase	phase	NOUN
admet-341	79	4	consisted	consist	VERB
admet-341	79	5	of	of	ADP
admet-341	79	6	0.1	0.1	NUM
admet-341	79	7	%	%	NOUN
admet-341	79	8	formic	formic	ADJ
admet-341	79	9	acid	acid	NOUN
admet-341	79	10	(	(	PUNCT
admet-341	79	11	a	a	NOUN
admet-341	79	12	)	)	PUNCT
admet-341	79	13	and	and	CCONJ
admet-341	79	14	methanol	methanol	NOUN
admet-341	79	15	(	(	PUNCT
admet-341	79	16	b	b	NOUN
admet-341	79	17	)	)	PUNCT
admet-341	79	18	.	.	PUNCT
admet-341	80	1	the	the	DET
admet-341	80	2	initial	initial	ADJ
admet-341	80	3	mobile	mobile	ADJ
admet-341	80	4	phase	phase	NOUN
admet-341	80	5	composition	composition	NOUN
admet-341	80	6	was	be	AUX
admet-341	80	7	80	80	NUM
admet-341	80	8	%	%	NOUN
admet-341	80	9	a/20	a/20	PROPN
admet-341	80	10	%	%	NOUN
admet-341	80	11	b	b	PROPN
admet-341	80	12	and	and	CCONJ
admet-341	80	13	continued	continue	VERB
admet-341	80	14	until	until	ADP
admet-341	80	15	1.0	1.0	NUM
admet-341	80	16	min	min	NOUN
admet-341	80	17	,	,	PUNCT
admet-341	80	18	then	then	ADV
admet-341	80	19	it	it	PRON
admet-341	80	20	was	be	AUX
admet-341	80	21	changed	change	VERB
admet-341	80	22	to	to	ADP
admet-341	80	23	5	5	NUM
admet-341	80	24	%	%	NOUN
admet-341	80	25	a/95	a/95	NOUN
admet-341	80	26	%	%	NOUN
admet-341	80	27	b	b	NOUN
admet-341	80	28	over	over	ADP
admet-341	80	29	2.1	2.1	NUM
admet-341	80	30	minutes	minute	NOUN
admet-341	80	31	.	.	PUNCT
admet-341	81	1	after	after	ADP
admet-341	81	2	2.1	2.1	NUM
admet-341	81	3	min	min	NOUN
admet-341	81	4	,	,	PUNCT
admet-341	81	5	the	the	DET
admet-341	81	6	mobile	mobile	ADJ
admet-341	81	7	phase	phase	NOUN
admet-341	81	8	is	be	AUX
admet-341	81	9	slowly	slowly	ADV
admet-341	81	10	shifted	shift	VERB
admet-341	81	11	to	to	ADP
admet-341	81	12	80	80	NUM
admet-341	81	13	%	%	NOUN
admet-341	81	14	a/20	a/20	PROPN
admet-341	81	15	%	%	NOUN
admet-341	81	16	b	b	NOUN
admet-341	81	17	by	by	ADP
admet-341	81	18	2.2	2.2	NUM
admet-341	81	19	min	min	NOUN
admet-341	81	20	following	following	ADP
admet-341	81	21	which	which	PRON
admet-341	81	22	it	it	PRON
admet-341	81	23	was	be	AUX
admet-341	81	24	held	hold	VERB
admet-341	81	25	at	at	ADP
admet-341	81	26	same	same	ADJ
admet-341	81	27	for	for	ADP
admet-341	81	28	3.2	3.2	NUM
admet-341	81	29	minutes	minute	NOUN
admet-341	81	30	.	.	PUNCT
admet-341	82	1	the	the	DET
admet-341	82	2	high	high	ADJ
admet-341	82	3	performance	performance	NOUN
admet-341	82	4	liquid	liquid	NOUN
admet-341	82	5	chromatography	chromatography	NOUN
admet-341	82	6	(	(	PUNCT
admet-341	82	7	hplc	hplc	PROPN
admet-341	82	8	)	)	PUNCT
admet-341	82	9	was	be	AUX
admet-341	82	10	interfaced	interface	VERB
admet-341	82	11	to	to	PART
admet-341	82	12	api	api	VERB
admet-341	82	13	4000	4000	NUM
admet-341	82	14	(	(	PUNCT
admet-341	82	15	ab	ab	PROPN
admet-341	82	16	sciex	sciex	PROPN
admet-341	82	17	,	,	PUNCT
admet-341	82	18	ca	ca	NOUN
admet-341	82	19	)	)	PUNCT
admet-341	82	20	mass	mass	NOUN
admet-341	82	21	spectrometer	spectrometer	NOUN
admet-341	82	22	operated	operate	VERB
admet-341	82	23	in	in	ADP
admet-341	82	24	the	the	DET
admet-341	82	25	positive	positive	ADJ
admet-341	82	26	ion	ion	NOUN
admet-341	82	27	electrospray	electrospray	VERB
admet-341	82	28	with	with	ADP
admet-341	82	29	multiple	multiple	ADJ
admet-341	82	30	reaction	reaction	NOUN
admet-341	82	31	monitoring	monitoring	NOUN
admet-341	82	32	(	(	PUNCT
admet-341	82	33	mrm	mrm	PROPN
admet-341	82	34	)	)	PUNCT
admet-341	82	35	mode	mode	NOUN
admet-341	82	36	.	.	PUNCT
admet-341	83	1	the	the	DET
admet-341	83	2	peak	peak	NOUN
admet-341	83	3	area	area	NOUN
admet-341	83	4	ratio	ratio	NOUN
admet-341	83	5	of	of	ADP
admet-341	83	6	analyte	analyte	NOUN
admet-341	83	7	to	to	ADP
admet-341	83	8	internal	internal	ADJ
admet-341	83	9	standard	standard	NOUN
admet-341	83	10	was	be	AUX
admet-341	83	11	plotted	plot	VERB
admet-341	83	12	against	against	ADP
admet-341	83	13	analyte	analyte	NOUN
admet-341	83	14	concentrations	concentration	NOUN
admet-341	83	15	,	,	PUNCT
admet-341	83	16	and	and	CCONJ
admet-341	83	17	the	the	DET
admet-341	83	18	standard	standard	ADJ
admet-341	83	19	curve	curve	NOUN
admet-341	83	20	and	and	CCONJ
admet-341	83	21	was	be	AUX
admet-341	83	22	fitted	fit	VERB
admet-341	83	23	by	by	ADP
admet-341	83	24	weighted	weight	VERB
admet-341	83	25	(	(	PUNCT
admet-341	83	26	1	1	NUM
admet-341	83	27	/	/	SYM
admet-341	83	28	x2	x2	ADJ
admet-341	83	29	)	)	PUNCT
admet-341	83	30	least	least	ADJ
admet-341	83	31	-	-	PUNCT
admet-341	83	32	squares	square	NOUN
admet-341	83	33	linear	linear	PROPN
admet-341	83	34	regression	regression	NOUN
admet-341	83	35	in	in	ADP
admet-341	83	36	the	the	DET
admet-341	83	37	concentration	concentration	NOUN
admet-341	83	38	ranged	range	VERB
admet-341	83	39	from	from	ADP
admet-341	83	40	1	1	NUM
admet-341	83	41	to	to	ADP
admet-341	83	42	1000	1000	NUM
admet-341	83	43	ng	ng	NOUN
admet-341	83	44	/	/	SYM
admet-341	83	45	ml	ml	PROPN
admet-341	83	46	.	.	PUNCT
admet-341	84	1	a	a	DET
admet-341	84	2	correlation	correlation	NOUN
admet-341	84	3	of	of	ADP
admet-341	84	4	0.995	0.995	NUM
admet-341	84	5	was	be	AUX
admet-341	84	6	desirable	desirable	ADJ
admet-341	84	7	for	for	ADP
admet-341	84	8	the	the	DET
admet-341	84	9	calibration	calibration	NOUN
admet-341	84	10	curve	curve	NOUN
admet-341	84	11	.	.	PUNCT
admet-341	85	1	the	the	DET
admet-341	85	2	limit	limit	NOUN
admet-341	85	3	of	of	ADP
admet-341	85	4	quantitation	quantitation	NOUN
admet-341	85	5	for	for	ADP
admet-341	85	6	the	the	DET
admet-341	85	7	purposes	purpose	NOUN
admet-341	85	8	of	of	ADP
admet-341	85	9	this	this	DET
admet-341	85	10	assay	assay	NOUN
admet-341	85	11	was	be	AUX
admet-341	85	12	1	1	NUM
admet-341	85	13	ng	ng	PROPN
admet-341	85	14	/	/	SYM
admet-341	85	15	ml	ml	PROPN
admet-341	85	16	.	.	PUNCT
admet-341	85	17	figure	figure	NOUN
admet-341	85	18	1	1	NUM
admet-341	85	19	.	.	PUNCT
admet-341	85	20	lc	lc	NOUN
admet-341	85	21	-	-	PUNCT
admet-341	85	22	ms	ms	PROPN
admet-341	85	23	spectra	spectra	PROPN
admet-341	85	24	representing	represent	VERB
admet-341	85	25	the	the	DET
admet-341	85	26	product	product	NOUN
admet-341	85	27	ion	ion	NOUN
admet-341	85	28	of	of	ADP
admet-341	85	29	gbo-006	gbo-006	ADJ
admet-341	85	30	pharmacokinetic	pharmacokinetic	ADJ
admet-341	85	31	analysis	analysis	NOUN
admet-341	85	32	the	the	DET
admet-341	85	33	pharmacokinetic	pharmacokinetic	ADJ
admet-341	85	34	parameters	parameter	NOUN
admet-341	85	35	were	be	AUX
admet-341	85	36	obtained	obtain	VERB
admet-341	85	37	by	by	ADP
admet-341	85	38	fitting	fit	VERB
admet-341	85	39	the	the	DET
admet-341	85	40	plasma	plasma	NOUN
admet-341	85	41	concentration	concentration	NOUN
admet-341	85	42	-	-	PUNCT
admet-341	85	43	time	time	NOUN
admet-341	85	44	data	datum	NOUN
admet-341	85	45	to	to	ADP
admet-341	85	46	a	a	DET
admet-341	85	47	noncompartmental	noncompartmental	ADJ
admet-341	85	48	model	model	NOUN
admet-341	85	49	by	by	ADP
admet-341	85	50	using	use	VERB
admet-341	85	51	phoenix	phoenix	PROPN
admet-341	85	52	winnonlin	winnonlin	PROPN
admet-341	85	53	-	-	PUNCT
admet-341	85	54	v6.3.0.395	v6.3.0.395	PROPN
admet-341	85	55	;	;	PUNCT
admet-341	85	56	(	(	PUNCT
admet-341	85	57	pharsight	pharsight	NOUN
admet-341	85	58	,	,	PUNCT
admet-341	85	59	mountain	mountain	NOUN
admet-341	85	60	view	view	NOUN
admet-341	85	61	,	,	PUNCT
admet-341	85	62	ca	ca	NOUN
admet-341	85	63	)	)	PUNCT
admet-341	85	64	.	.	PUNCT
admet-341	86	1	the	the	DET
admet-341	86	2	maximum	maximum	ADJ
admet-341	86	3	plasma	plasma	NOUN
admet-341	86	4	concentration	concentration	NOUN
admet-341	86	5	(	(	PUNCT
admet-341	86	6	cmax	cmax	NOUN
admet-341	86	7	)	)	PUNCT
admet-341	86	8	and	and	CCONJ
admet-341	86	9	the	the	DET
admet-341	86	10	time	time	NOUN
admet-341	86	11	to	to	PART
admet-341	86	12	reach	reach	VERB
admet-341	86	13	the	the	DET
admet-341	86	14	same	same	ADJ
admet-341	86	15	(	(	PUNCT
admet-341	86	16	tmax	tmax	ADV
admet-341	86	17	)	)	PUNCT
admet-341	86	18	were	be	AUX
admet-341	86	19	determined	determine	VERB
admet-341	86	20	by	by	ADP
admet-341	86	21	visually	visually	ADV
admet-341	86	22	inspecting	inspect	VERB
admet-341	86	23	the	the	DET
admet-341	86	24	profiles	profile	NOUN
admet-341	86	25	of	of	ADP
admet-341	86	26	plasma	plasma	NOUN
admet-341	86	27	drug	drug	NOUN
admet-341	86	28	levels	level	NOUN
admet-341	86	29	versus	versus	ADP
admet-341	86	30	time	time	NOUN
admet-341	86	31	.	.	PUNCT
admet-341	87	1	the	the	DET
admet-341	87	2	half	half	ADJ
admet-341	87	3	-	-	PUNCT
admet-341	87	4	life	life	NOUN
admet-341	87	5	of	of	ADP
admet-341	87	6	plasma	plasma	NOUN
admet-341	87	7	drug	drug	NOUN
admet-341	87	8	elimination	elimination	NOUN
admet-341	87	9	(	(	PUNCT
admet-341	87	10	t1/2	t1/2	NOUN
admet-341	87	11	)	)	PUNCT
admet-341	87	12	was	be	AUX
admet-341	87	13	the	the	DET
admet-341	87	14	ratio	ratio	NOUN
admet-341	87	15	of	of	ADP
admet-341	87	16	0.693	0.693	NUM
admet-341	87	17	to	to	ADP
admet-341	87	18	the	the	DET
admet-341	87	19	slope	slope	NOUN
admet-341	87	20	obtained	obtain	VERB
admet-341	87	21	by	by	ADP
admet-341	87	22	log	log	NOUN
admet-341	87	23	-	-	PUNCT
admet-341	87	24	linear	linear	NOUN
admet-341	87	25	regression	regression	NOUN
admet-341	87	26	of	of	ADP
admet-341	87	27	the	the	DET
admet-341	87	28	terminal	terminal	ADJ
admet-341	87	29	phase	phase	NOUN
admet-341	87	30	of	of	ADP
admet-341	87	31	the	the	DET
admet-341	87	32	drug	drug	NOUN
admet-341	87	33	plasma	plasma	NOUN
admet-341	87	34	profile	profile	NOUN
admet-341	87	35	.	.	PUNCT
admet-341	88	1	the	the	DET
admet-341	88	2	area	area	NOUN
admet-341	88	3	under	under	ADP
admet-341	88	4	the	the	DET
admet-341	88	5	concentration	concentration	NOUN
admet-341	88	6	-	-	PUNCT
admet-341	88	7	time	time	NOUN
admet-341	88	8	curve	curve	NOUN
admet-341	88	9	to	to	PART
admet-341	88	10	terminal	terminal	VERB
admet-341	88	11	time	time	NOUN
admet-341	88	12	auc0	auc0	PROPN
admet-341	88	13	-	-	PUNCT
admet-341	88	14	t	t	PROPN
admet-341	88	15	)	)	PUNCT
admet-341	88	16	,	,	PUNCT
admet-341	88	17	(	(	PUNCT
admet-341	88	18	area	area	NOUN
admet-341	88	19	under	under	ADP
admet-341	88	20	the	the	DET
admet-341	88	21	concentration	concentration	NOUN
admet-341	88	22	-	-	PUNCT
admet-341	88	23	time	time	NOUN
admet-341	88	24	curve	curve	NOUN
admet-341	88	25	to	to	PART
admet-341	88	26	infinite	infinite	VERB
admet-341	88	27	time	time	NOUN
admet-341	88	28	(	(	PUNCT
admet-341	88	29	auc0-∞	auc0-∞	NUM
admet-341	88	30	)	)	PUNCT
admet-341	88	31	and	and	CCONJ
admet-341	88	32	the	the	DET
admet-341	88	33	mean	mean	ADJ
admet-341	88	34	residence	residence	NOUN
admet-341	88	35	time	time	NOUN
admet-341	88	36	(	(	PUNCT
admet-341	88	37	mrt	mrt	NOUN
admet-341	88	38	)	)	PUNCT
admet-341	88	39	were	be	AUX
admet-341	88	40	also	also	ADV
admet-341	88	41	evaluated	evaluate	VERB
admet-341	88	42	.	.	PUNCT
admet-341	89	1	auct	auct	PROPN
admet-341	89	2	was	be	AUX
admet-341	89	3	calculated	calculate	VERB
admet-341	89	4	by	by	ADP
admet-341	89	5	the	the	DET
admet-341	89	6	linear	linear	PROPN
admet-341	89	7	/	/	SYM
admet-341	89	8	log	log	NOUN
admet-341	89	9	trapezoidal	trapezoidal	ADJ
admet-341	89	10	rule	rule	NOUN
admet-341	89	11	.	.	PUNCT
admet-341	90	1	other	other	ADJ
admet-341	90	2	pharmacokinetic	pharmacokinetic	ADJ
admet-341	90	3	variables	variable	NOUN
admet-341	90	4	,	,	PUNCT
admet-341	90	5	including	include	VERB
admet-341	90	6	the	the	DET
admet-341	90	7	total	total	ADJ
admet-341	90	8	plasma	plasma	NOUN
admet-341	90	9	clearance	clearance	NOUN
admet-341	90	10	(	(	PUNCT
admet-341	90	11	cl	cl	NOUN
admet-341	90	12	)	)	PUNCT
admet-341	90	13	,	,	PUNCT
admet-341	90	14	steady	steady	ADJ
admet-341	90	15	-	-	PUNCT
admet-341	90	16	state	state	NOUN
admet-341	90	17	volume	volume	NOUN
admet-341	90	18	of	of	ADP
admet-341	90	19	distribution	distribution	NOUN
admet-341	90	20	(	(	PUNCT
admet-341	90	21	vss	vss	NOUN
admet-341	90	22	)	)	PUNCT
admet-341	90	23	,	,	PUNCT
admet-341	90	24	and	and	CCONJ
admet-341	90	25	oral	oral	ADJ
admet-341	90	26	bioavailability	bioavailability	NOUN
admet-341	90	27	(	(	PUNCT
admet-341	90	28	%	%	NOUN
admet-341	90	29	f	f	X
admet-341	90	30	)	)	PUNCT
admet-341	90	31	were	be	AUX
admet-341	90	32	also	also	ADV
admet-341	90	33	calculated	calculate	VERB
admet-341	90	34	.	.	PUNCT
admet-341	91	1	xenograft	xenograft	PROPN
admet-341	91	2	study	study	VERB
admet-341	91	3	all	all	DET
admet-341	91	4	animal	animal	NOUN
admet-341	91	5	studies	study	NOUN
admet-341	91	6	were	be	AUX
admet-341	91	7	performed	perform	VERB
admet-341	91	8	according	accord	VERB
admet-341	91	9	to	to	ADP
admet-341	91	10	the	the	DET
admet-341	91	11	guidelines	guideline	NOUN
admet-341	91	12	and	and	CCONJ
admet-341	91	13	approval	approval	NOUN
admet-341	91	14	of	of	ADP
admet-341	91	15	the	the	DET
admet-341	91	16	appropriate	appropriate	ADJ
admet-341	91	17	animal	animal	NOUN
admet-341	91	18	care	care	NOUN
admet-341	91	19	committees	committee	NOUN
admet-341	91	20	.	.	PUNCT
admet-341	92	1	female	female	ADJ
admet-341	92	2	scid	scid	VERB
admet-341	92	3	beige	beige	ADJ
admet-341	92	4	mice	mouse	NOUN
admet-341	92	5	4–6	4–6	NUM
admet-341	92	6	weeks	week	NOUN
admet-341	92	7	of	of	ADP
admet-341	92	8	age	age	NOUN
admet-341	92	9	were	be	AUX
admet-341	92	10	purchased	purchase	VERB
admet-341	92	11	from	from	ADP
admet-341	92	12	taconic	taconic	NOUN
admet-341	92	13	laboratories	laboratory	NOUN
admet-341	92	14	(	(	PUNCT
admet-341	92	15	vivo	vivo	NOUN
admet-341	92	16	biotech	biotech	NOUN
admet-341	92	17	,	,	PUNCT
admet-341	92	18	hyderabad	hyderabad	PROPN
admet-341	92	19	,	,	PUNCT
admet-341	92	20	india	india	PROPN
admet-341	92	21	)	)	PUNCT
admet-341	92	22	and	and	CCONJ
admet-341	92	23	housed	house	VERB
admet-341	92	24	in	in	ADP
admet-341	92	25	a	a	DET
admet-341	92	26	pathogen	pathogen	NOUN
admet-341	92	27	-	-	PUNCT
admet-341	92	28	free	free	ADJ
admet-341	92	29	environment	environment	NOUN
admet-341	92	30	under	under	ADP
admet-341	92	31	controlled	control	VERB
admet-341	92	32	conditions	condition	NOUN
admet-341	93	1	+	+	PROPN
admet-341	93	2	ms2	ms2	NOUN
admet-341	93	3	(	(	PUNCT
admet-341	93	4	468.30	468.30	NUM
admet-341	93	5	):	):	PUNCT
admet-341	93	6	40.000	40.000	NUM
admet-341	93	7	volts	volt	NOUN
admet-341	93	8	from	from	ADP
admet-341	93	9	sample	sample	NOUN
admet-341	93	10	2	2	NUM
admet-341	93	11	(	(	PUNCT
admet-341	93	12	tunesampleid	tunesampleid	NOUN
admet-341	93	13	)	)	PUNCT
admet-341	93	14	of	of	ADP
admet-341	93	15	gbo-006-q3.wiff	gbo-006-q3.wiff	PROPN
admet-341	93	16	(	(	PUNCT
admet-341	93	17	turbo	turbo	NOUN
admet-341	93	18	spray	spray	NOUN
admet-341	93	19	)	)	PUNCT
admet-341	93	20	,	,	PUNCT
admet-341	93	21	centroided	centroide	VERB
admet-341	93	22	max	max	PROPN
admet-341	93	23	.	.	PROPN
admet-341	94	1	6.9e5	6.9e5	NUM
admet-341	94	2	cps	cps	PROPN
admet-341	94	3	.	.	PROPN
admet-341	95	1	60	60	NUM
admet-341	95	2	80	80	NUM
admet-341	95	3	100	100	NUM
admet-341	95	4	120	120	NUM
admet-341	95	5	140	140	NUM
admet-341	95	6	160	160	NUM
admet-341	95	7	180	180	NUM
admet-341	95	8	200	200	NUM
admet-341	95	9	220	220	NUM
admet-341	95	10	240	240	NUM
admet-341	95	11	260	260	NUM
admet-341	95	12	280	280	NUM
admet-341	95	13	300	300	NUM
admet-341	95	14	320	320	NUM
admet-341	95	15	340	340	NUM
admet-341	95	16	360	360	NUM
admet-341	95	17	380	380	NUM
admet-341	95	18	400	400	NUM
admet-341	95	19	420	420	NUM
admet-341	95	20	440	440	NUM
admet-341	95	21	460	460	NUM
admet-341	95	22	480	480	NUM
admet-341	95	23	500	500	NUM
admet-341	95	24	m	m	PROPN
admet-341	95	25	/	/	SYM
admet-341	96	1	z	z	NOUN
admet-341	96	2	,	,	PUNCT
admet-341	96	3	da	da	PROPN
admet-341	96	4	0.0	0.0	NUM
admet-341	96	5	5.0e4	5.0e4	NUM
admet-341	96	6	1.0e5	1.0e5	NUM
admet-341	96	7	1.5e5	1.5e5	NUM
admet-341	96	8	2.0e5	2.0e5	NUM
admet-341	96	9	2.5e5	2.5e5	NUM
admet-341	96	10	3.0e5	3.0e5	NUM
admet-341	96	11	3.5e5	3.5e5	NUM
admet-341	96	12	4.0e5	4.0e5	NUM
admet-341	96	13	4.5e5	4.5e5	NUM
admet-341	96	14	5.0e5	5.0e5	NUM
admet-341	96	15	5.5e5	5.5e5	NUM
admet-341	96	16	6.0e5	6.0e5	NUM
admet-341	96	17	6.5e5	6.5e5	NUM
admet-341	96	18	6.9e5	6.9e5	NUM
admet-341	97	1	i	i	PRON
admet-341	97	2	n	n	VERB
admet-341	97	3	t	t	X
admet-341	97	4	e	e	NOUN
admet-341	97	5	n	n	X
admet-341	97	6	s	s	VERB
admet-341	97	7	it	it	PRON
admet-341	97	8	y	y	PROPN
admet-341	97	9	,	,	PUNCT
admet-341	97	10	c	c	PROPN
admet-341	98	1	p	p	PROPN
admet-341	98	2	s	s	PROPN
admet-341	98	3	468.0	468.0	NUM
admet-341	98	4	261.9	261.9	NUM
admet-341	98	5	290.2	290.2	NUM
admet-341	98	6	221.3	221.3	NUM
admet-341	98	7	468.8	468.8	NUM
admet-341	98	8	403.1263.3	403.1263.3	NUM
admet-341	98	9	278.0228.8	278.0228.8	NUM
admet-341	98	10	srinivas	srinivas	PROPN
admet-341	98	11	maddi	maddi	PROPN
admet-341	98	12	et	et	PROPN
admet-341	98	13	al	al	PROPN
admet-341	98	14	.	.	PROPN
admet-341	98	15	admet	admet	PROPN
admet-341	98	16	&	&	CCONJ
admet-341	98	17	dmpk	dmpk	PROPN
admet-341	98	18	4(4	4(4	NUM
admet-341	98	19	)	)	PUNCT
admet-341	98	20	(	(	PUNCT
admet-341	98	21	2016	2016	NUM
admet-341	98	22	)	)	PUNCT
admet-341	98	23	314	314	NUM
admet-341	98	24	-	-	SYM
admet-341	98	25	326	326	NUM
admet-341	98	26	318	318	NUM
admet-341	98	27	of	of	ADP
admet-341	98	28	light	light	NOUN
admet-341	98	29	and	and	CCONJ
admet-341	98	30	humidity	humidity	NOUN
admet-341	98	31	and	and	CCONJ
admet-341	98	32	allowed	allow	VERB
admet-341	98	33	free	free	ADJ
admet-341	98	34	access	access	NOUN
admet-341	98	35	to	to	ADP
admet-341	98	36	food	food	NOUN
admet-341	98	37	and	and	CCONJ
admet-341	98	38	water	water	NOUN
admet-341	98	39	.	.	PUNCT
admet-341	99	1	tumors	tumor	NOUN
admet-341	99	2	were	be	AUX
admet-341	99	3	developed	develop	VERB
admet-341	99	4	from	from	ADP
admet-341	99	5	mda	mda	PROPN
admet-341	99	6	-	-	PUNCT
admet-341	99	7	mb231	mb231	ADJ
admet-341	99	8	cells	cell	NOUN
admet-341	99	9	inoculated	inoculate	VERB
admet-341	99	10	subcutaneously	subcutaneously	ADV
admet-341	99	11	(	(	PUNCT
admet-341	99	12	sc	sc	NOUN
admet-341	99	13	)	)	PUNCT
admet-341	99	14	into	into	ADP
admet-341	99	15	each	each	DET
admet-341	99	16	mouse	mouse	NOUN
admet-341	99	17	as	as	SCONJ
admet-341	99	18	previously	previously	ADV
admet-341	99	19	described	describe	VERB
admet-341	99	20	[	[	X
admet-341	99	21	10	10	NUM
admet-341	99	22	]	]	PUNCT
admet-341	99	23	.	.	PUNCT
admet-341	100	1	mda	mda	PROPN
admet-341	100	2	-	-	PUNCT
admet-341	100	3	mb-231	mb-231	PROPN
admet-341	100	4	cells	cell	NOUN
admet-341	100	5	were	be	AUX
admet-341	100	6	grown	grow	VERB
admet-341	100	7	in	in	ADP
admet-341	100	8	rpmi	rpmi	NOUN
admet-341	100	9	1640	1640	NUM
admet-341	100	10	w/	w/	NOUN
admet-341	100	11	10	10	NUM
admet-341	100	12	%	%	NOUN
admet-341	100	13	fbs	fb	VERB
admet-341	100	14	,	,	PUNCT
admet-341	100	15	2	2	NUM
admet-341	100	16	%	%	NOUN
admet-341	100	17	p	p	X
admet-341	100	18	/	/	SYM
admet-341	100	19	s	s	PROPN
admet-341	100	20	,	,	PUNCT
admet-341	100	21	1.25	1.25	NUM
admet-341	100	22	%	%	NOUN
admet-341	100	23	l	l	NOUN
admet-341	100	24	-	-	NOUN
admet-341	100	25	glut	glut	ADJ
admet-341	100	26	,	,	PUNCT
admet-341	100	27	and	and	CCONJ
admet-341	100	28	1	1	NUM
admet-341	100	29	%	%	NOUN
admet-341	100	30	sodium	sodium	NOUN
admet-341	100	31	pyruvate	pyruvate	NOUN
admet-341	100	32	to	to	ADP
admet-341	100	33	80	80	NUM
admet-341	100	34	%	%	NOUN
admet-341	100	35	confluency	confluency	NOUN
admet-341	100	36	.	.	PUNCT
admet-341	101	1	cells	cell	NOUN
admet-341	101	2	were	be	AUX
admet-341	101	3	trypsinized	trypsinize	VERB
admet-341	101	4	with	with	ADP
admet-341	101	5	0.25	0.25	NUM
admet-341	101	6	%	%	NOUN
admet-341	101	7	trypsin	trypsin	NOUN
admet-341	101	8	for	for	ADP
admet-341	101	9	3	3	NUM
admet-341	101	10	-	-	SYM
admet-341	101	11	5	5	NUM
admet-341	101	12	minutes	minute	NOUN
admet-341	101	13	,	,	PUNCT
admet-341	101	14	washed	wash	VERB
admet-341	101	15	and	and	CCONJ
admet-341	101	16	suspended	suspend	VERB
admet-341	101	17	at	at	ADP
admet-341	101	18	100	100	NUM
admet-341	101	19	million	million	NUM
admet-341	101	20	cells	cell	NOUN
admet-341	101	21	per	per	ADP
admet-341	101	22	ml	ml	NOUN
admet-341	101	23	.	.	PUNCT
admet-341	102	1	animals	animal	NOUN
admet-341	102	2	received	receive	VERB
admet-341	102	3	5	5	NUM
admet-341	102	4	million	million	NUM
admet-341	102	5	cells	cell	NOUN
admet-341	102	6	in	in	ADP
admet-341	102	7	matrigel	matrigel	NOUN
admet-341	102	8	(	(	PUNCT
admet-341	102	9	1:1	1:1	NUM
admet-341	102	10	ratio	ratio	NOUN
admet-341	102	11	of	of	ADP
admet-341	102	12	media	medium	NOUN
admet-341	102	13	and	and	CCONJ
admet-341	102	14	matrigel	matrigel	NOUN
admet-341	102	15	)	)	PUNCT
admet-341	102	16	and	and	CCONJ
admet-341	102	17	injected	inject	VERB
admet-341	102	18	subcutaneously	subcutaneously	ADV
admet-341	102	19	at	at	ADP
admet-341	102	20	the	the	DET
admet-341	102	21	flank	flank	NOUN
admet-341	102	22	.	.	PUNCT
admet-341	103	1	tumors	tumor	NOUN
admet-341	103	2	were	be	AUX
admet-341	103	3	measured	measure	VERB
admet-341	103	4	three	three	NUM
admet-341	103	5	times	time	NOUN
admet-341	103	6	a	a	DET
admet-341	103	7	week	week	NOUN
admet-341	103	8	with	with	ADP
admet-341	103	9	vernier	vernier	PROPN
admet-341	103	10	calipers	caliper	NOUN
admet-341	103	11	and	and	CCONJ
admet-341	103	12	tumor	tumor	NOUN
admet-341	103	13	volume	volume	NOUN
admet-341	103	14	measured	measure	VERB
admet-341	103	15	using	use	VERB
admet-341	103	16	the	the	DET
admet-341	103	17	formula	formula	NOUN
admet-341	103	18	length	length	NOUN
admet-341	103	19	x	x	X
admet-341	103	20	width	width	PROPN
admet-341	103	21	2/2	2/2	NUM
admet-341	103	22	.	.	PUNCT
admet-341	104	1	treatment	treatment	NOUN
admet-341	104	2	was	be	AUX
admet-341	104	3	initiated	initiate	VERB
admet-341	104	4	when	when	SCONJ
admet-341	104	5	the	the	DET
admet-341	104	6	tumors	tumor	NOUN
admet-341	104	7	reached	reach	VERB
admet-341	104	8	an	an	DET
admet-341	104	9	average	average	ADJ
admet-341	104	10	volume	volume	NOUN
admet-341	104	11	of	of	ADP
admet-341	104	12	100	100	NUM
admet-341	104	13	mm3	mm3	NOUN
admet-341	104	14	.	.	PUNCT
admet-341	105	1	one	one	NUM
admet-341	105	2	group	group	NOUN
admet-341	105	3	was	be	AUX
admet-341	105	4	dosed	dose	VERB
admet-341	105	5	with	with	ADP
admet-341	105	6	the	the	DET
admet-341	105	7	formulation	formulation	NOUN
admet-341	105	8	{	{	PUNCT
admet-341	105	9	(	(	PUNCT
admet-341	105	10	20	20	NUM
admet-341	105	11	%	%	NOUN
admet-341	105	12	v	v	ADP
admet-341	105	13	/	/	SYM
admet-341	105	14	v	v	NOUN
admet-341	105	15	dmso	dmso	NOUN
admet-341	105	16	+	+	CCONJ
admet-341	105	17	40	40	NUM
admet-341	105	18	%	%	NOUN
admet-341	105	19	w	w	NOUN
admet-341	105	20	/	/	SYM
admet-341	105	21	v	v	NUM
admet-341	105	22	peg	peg	NOUN
admet-341	105	23	400	400	NUM
admet-341	105	24	+	+	CCONJ
admet-341	105	25	10	10	NUM
admet-341	105	26	%	%	NOUN
admet-341	105	27	w	w	NOUN
admet-341	105	28	/	/	SYM
admet-341	105	29	v	v	NOUN
admet-341	105	30	solutol	solutol	NOUN
admet-341	105	31	+	+	CCONJ
admet-341	105	32	30	30	NUM
admet-341	105	33	%	%	NOUN
admet-341	105	34	v	v	ADP
admet-341	105	35	/	/	SYM
admet-341	105	36	v	v	NOUN
admet-341	105	37	citrate	citrate	NOUN
admet-341	105	38	buffer	buffer	NOUN
admet-341	105	39	(	(	PUNCT
admet-341	105	40	100	100	NUM
admet-341	105	41	mm	mm	NOUN
admet-341	105	42	)	)	PUNCT
admet-341	105	43	}	}	PUNCT
admet-341	105	44	with	with	ADP
admet-341	105	45	the	the	DET
admet-341	105	46	dose	dose	NOUN
admet-341	105	47	volume	volume	NOUN
admet-341	105	48	of	of	ADP
admet-341	105	49	10	10	NUM
admet-341	105	50	ml	ml	NOUN
admet-341	105	51	/	/	SYM
admet-341	105	52	kg	kg	PROPN
admet-341	105	53	as	as	ADP
admet-341	105	54	a	a	DET
admet-341	105	55	vehicle	vehicle	NOUN
admet-341	105	56	control	control	NOUN
admet-341	105	57	,	,	PUNCT
admet-341	105	58	whereas	whereas	SCONJ
admet-341	105	59	the	the	DET
admet-341	105	60	two	two	NUM
admet-341	105	61	other	other	ADJ
admet-341	105	62	groups	group	NOUN
admet-341	105	63	were	be	AUX
admet-341	105	64	dosed	dose	VERB
admet-341	105	65	via	via	ADP
admet-341	105	66	intraperitoneal	intraperitoneal	ADJ
admet-341	105	67	route	route	NOUN
admet-341	105	68	with	with	ADP
admet-341	105	69	30	30	NUM
admet-341	105	70	and	and	CCONJ
admet-341	105	71	75	75	NUM
admet-341	105	72	/	/	SYM
admet-341	105	73	mg	mg	PROPN
admet-341	105	74	/	/	SYM
admet-341	105	75	kg	kg	NOUN
admet-341	105	76	gbo-006	gbo-006	NOUN
admet-341	105	77	.	.	PUNCT
admet-341	106	1	all	all	DET
admet-341	106	2	dosing	dose	VERB
admet-341	106	3	were	be	AUX
admet-341	106	4	done	do	VERB
admet-341	106	5	once	once	ADV
admet-341	106	6	daily	daily	ADV
admet-341	106	7	(	(	PUNCT
admet-341	106	8	qd	qd	NOUN
admet-341	106	9	)	)	PUNCT
admet-341	106	10	for	for	ADP
admet-341	106	11	24	24	NUM
admet-341	106	12	days	day	NOUN
admet-341	106	13	.	.	PUNCT
admet-341	107	1	animal	animal	NOUN
admet-341	107	2	body	body	NOUN
admet-341	107	3	weights	weight	NOUN
admet-341	107	4	were	be	AUX
admet-341	107	5	taken	take	VERB
admet-341	107	6	every	every	DET
admet-341	107	7	alternate	alternate	ADJ
admet-341	107	8	day	day	NOUN
admet-341	107	9	,	,	PUNCT
admet-341	107	10	and	and	CCONJ
admet-341	107	11	they	they	PRON
admet-341	107	12	were	be	AUX
admet-341	107	13	monitored	monitor	VERB
admet-341	107	14	for	for	ADP
admet-341	107	15	general	general	ADJ
admet-341	107	16	health	health	NOUN
admet-341	107	17	status	status	NOUN
admet-341	107	18	and	and	CCONJ
admet-341	107	19	any	any	DET
admet-341	107	20	possible	possible	ADJ
admet-341	107	21	signs	sign	NOUN
admet-341	107	22	of	of	ADP
admet-341	107	23	treatment	treatment	NOUN
admet-341	107	24	related	relate	VERB
admet-341	107	25	toxicity	toxicity	NOUN
admet-341	107	26	.	.	PUNCT
admet-341	108	1	results	result	VERB
admet-341	108	2	development	development	NOUN
admet-341	108	3	of	of	ADP
admet-341	108	4	formulation	formulation	NOUN
admet-341	108	5	of	of	ADP
admet-341	108	6	gbo-006	gbo-006	X
admet-341	108	7	various	various	ADJ
admet-341	108	8	percentage	percentage	NOUN
admet-341	108	9	compositions	composition	NOUN
admet-341	108	10	of	of	ADP
admet-341	108	11	water	water	NOUN
admet-341	108	12	soluble	soluble	ADJ
admet-341	108	13	organic	organic	ADJ
admet-341	108	14	cosolvents	cosolvent	NOUN
admet-341	108	15	,	,	PUNCT
admet-341	108	16	surfactants	surfactant	NOUN
admet-341	108	17	were	be	AUX
admet-341	108	18	evaluated	evaluate	VERB
admet-341	108	19	for	for	ADP
admet-341	108	20	an	an	DET
admet-341	108	21	optimized	optimize	VERB
admet-341	108	22	gbo-006	gbo-006	NOUN
admet-341	108	23	formulation	formulation	NOUN
admet-341	108	24	(	(	PUNCT
admet-341	108	25	table	table	NOUN
admet-341	108	26	1	1	NUM
admet-341	108	27	)	)	PUNCT
admet-341	108	28	.	.	PUNCT
admet-341	109	1	gbo-006	gbo-006	NOUN
admet-341	109	2	concentrations	concentration	NOUN
admet-341	109	3	in	in	ADP
admet-341	109	4	these	these	DET
admet-341	109	5	formulations	formulation	NOUN
admet-341	109	6	were	be	AUX
admet-341	109	7	kept	keep	VERB
admet-341	109	8	fixed	fix	VERB
admet-341	109	9	at	at	ADP
admet-341	109	10	10	10	NUM
admet-341	109	11	mg	mg	NUM
admet-341	109	12	/	/	SYM
admet-341	109	13	ml	ml	NOUN
admet-341	109	14	.	.	PUNCT
admet-341	110	1	among	among	ADP
admet-341	110	2	these	these	DET
admet-341	110	3	formulations	formulation	NOUN
admet-341	110	4	(	(	PUNCT
admet-341	110	5	#	#	SYM
admet-341	110	6	a	a	NOUN
admet-341	110	7	-	-	PUNCT
admet-341	110	8	k	k	NOUN
admet-341	110	9	)	)	PUNCT
admet-341	110	10	,	,	PUNCT
admet-341	110	11	gbo-006	gbo-006	NOUN
admet-341	110	12	was	be	AUX
admet-341	110	13	initially	initially	ADV
admet-341	110	14	dissolved	dissolve	VERB
admet-341	110	15	and	and	CCONJ
admet-341	110	16	subsequently	subsequently	ADV
admet-341	110	17	exhibited	exhibit	VERB
admet-341	110	18	various	various	ADJ
admet-341	110	19	degrees	degree	NOUN
admet-341	110	20	of	of	ADP
admet-341	110	21	precipitation	precipitation	NOUN
admet-341	110	22	after	after	ADP
admet-341	110	23	24	24	NUM
admet-341	110	24	h	h	NOUN
admet-341	110	25	storage	storage	NOUN
admet-341	110	26	at	at	ADP
admet-341	110	27	room	room	NOUN
admet-341	110	28	temperature	temperature	NOUN
admet-341	110	29	.	.	PUNCT
admet-341	111	1	however	however	ADV
admet-341	111	2	,	,	PUNCT
admet-341	111	3	formulation	formulation	NOUN
admet-341	111	4	#	#	SYM
admet-341	111	5	l	l	NOUN
admet-341	111	6	with	with	ADP
admet-341	111	7	20	20	NUM
admet-341	111	8	%	%	NOUN
admet-341	111	9	dmso	dmso	NOUN
admet-341	111	10	,	,	PUNCT
admet-341	111	11	40	40	NUM
admet-341	111	12	%	%	NOUN
admet-341	111	13	peg	peg	NOUN
admet-341	111	14	400	400	NUM
admet-341	111	15	,	,	PUNCT
admet-341	111	16	30	30	NUM
admet-341	111	17	%	%	NOUN
admet-341	111	18	of	of	ADP
admet-341	111	19	100	100	NUM
admet-341	111	20	mm	mm	NOUN
admet-341	111	21	citrate	citrate	NOUN
admet-341	111	22	buffer	buffer	NOUN
admet-341	111	23	(	(	PUNCT
admet-341	111	24	ph	ph	NOUN
admet-341	111	25	3.0	3.0	NUM
admet-341	111	26	)	)	PUNCT
admet-341	111	27	and	and	CCONJ
admet-341	111	28	10	10	NUM
admet-341	111	29	%	%	NOUN
admet-341	111	30	solutol	solutol	NOUN
admet-341	111	31	displayed	display	VERB
admet-341	111	32	clear	clear	ADJ
admet-341	111	33	solutions	solution	NOUN
admet-341	111	34	without	without	ADP
admet-341	111	35	any	any	DET
admet-341	111	36	visual	visual	ADJ
admet-341	111	37	precipitation	precipitation	NOUN
admet-341	111	38	of	of	ADP
admet-341	111	39	the	the	DET
admet-341	111	40	drug	drug	NOUN
admet-341	111	41	even	even	ADV
admet-341	111	42	after	after	ADP
admet-341	111	43	2	2	NUM
admet-341	111	44	weeks	week	NOUN
admet-341	111	45	of	of	ADP
admet-341	111	46	storage	storage	NOUN
admet-341	111	47	.	.	PUNCT
admet-341	112	1	therefore	therefore	ADV
admet-341	112	2	,	,	PUNCT
admet-341	112	3	this	this	DET
admet-341	112	4	formulation	formulation	NOUN
admet-341	112	5	was	be	AUX
admet-341	112	6	selected	select	VERB
admet-341	112	7	for	for	ADP
admet-341	112	8	in	in	ADP
admet-341	112	9	vivo	vivo	ADJ
admet-341	112	10	pharmacokinetic	pharmacokinetic	ADJ
admet-341	112	11	and	and	CCONJ
admet-341	112	12	efficacy	efficacy	NOUN
admet-341	112	13	studies	study	NOUN
admet-341	112	14	.	.	PUNCT
admet-341	113	1	table	table	NOUN
admet-341	113	2	1	1	NUM
admet-341	113	3	.	.	PUNCT
admet-341	114	1	formulation	formulation	NOUN
admet-341	114	2	trails	trail	NOUN
admet-341	114	3	for	for	ADP
admet-341	114	4	gbo-006	gbo-006	NOUN
admet-341	114	5	at	at	ADP
admet-341	114	6	10	10	NUM
admet-341	114	7	mg	mg	NUM
admet-341	114	8	/	/	SYM
admet-341	114	9	ml	ml	VERB
admet-341	114	10	by	by	ADP
admet-341	114	11	solvation	solvation	NOUN
admet-341	114	12	strategy	strategy	NOUN
admet-341	114	13	using	use	VERB
admet-341	114	14	co	co	NOUN
admet-341	114	15	-	-	NOUN
admet-341	114	16	solvents	solvent	NOUN
admet-341	114	17	and	and	CCONJ
admet-341	114	18	surfactants	surfactant	NOUN
admet-341	114	19	formula	formula	NOUN
admet-341	114	20	vehicle	vehicle	NOUN
admet-341	114	21	composition	composition	NOUN
admet-341	114	22	appearance	appearance	NOUN
admet-341	114	23	at	at	ADP
admet-341	114	24	crt	crt	ADJ
admet-341	114	25	a	a	DET
admet-341	114	26	20	20	NUM
admet-341	114	27	%	%	NOUN
admet-341	114	28	v	v	ADP
admet-341	114	29	/	/	SYM
admet-341	114	30	v	v	NOUN
admet-341	114	31	nmp	nmp	NOUN
admet-341	114	32	+	+	CCONJ
admet-341	114	33	20	20	NUM
admet-341	114	34	%	%	NOUN
admet-341	114	35	v	v	ADP
admet-341	114	36	/	/	SYM
admet-341	114	37	v	v	NOUN
admet-341	114	38	ethanol	ethanol	NOUN
admet-341	114	39	+	+	CCONJ
admet-341	114	40	20	20	NUM
admet-341	114	41	%	%	NOUN
admet-341	114	42	v	v	ADP
admet-341	114	43	/	/	SYM
admet-341	114	44	v	v	NOUN
admet-341	114	45	peg	peg	NOUN
admet-341	114	46	400	400	NUM
admet-341	114	47	+	+	SYM
admet-341	114	48	10	10	NUM
admet-341	114	49	%	%	NOUN
admet-341	114	50	w	w	NOUN
admet-341	114	51	/	/	SYM
admet-341	114	52	v	v	NUM
admet-341	114	53	tpgs	tpgs	NOUN
admet-341	114	54	+	+	CCONJ
admet-341	114	55	1	1	NUM
admet-341	114	56	%	%	NOUN
admet-341	114	57	w	w	NOUN
admet-341	114	58	/	/	SYM
admet-341	114	59	v	v	NOUN
admet-341	114	60	poloxamer	poloxamer	NOUN
admet-341	114	61	188	188	NUM
admet-341	114	62	+	+	CCONJ
admet-341	114	63	purified	purified	ADJ
admet-341	114	64	water	water	NOUN
admet-341	114	65	q.s	q.s	PROPN
admet-341	114	66	.	.	PUNCT
admet-341	114	67	precipitation	precipitation	NOUN
admet-341	114	68	after	after	ADP
admet-341	114	69	8h	8h	PROPN
admet-341	114	70	b	b	SYM
admet-341	114	71	20	20	NUM
admet-341	114	72	%	%	NOUN
admet-341	114	73	v	v	ADP
admet-341	114	74	/	/	SYM
admet-341	114	75	v	v	NOUN
admet-341	114	76	nmp	nmp	NOUN
admet-341	114	77	+	+	CCONJ
admet-341	114	78	20	20	NUM
admet-341	114	79	%	%	NOUN
admet-341	114	80	w	w	NOUN
admet-341	114	81	/	/	SYM
admet-341	114	82	v	v	NOUN
admet-341	114	83	glycerin+	glycerin+	NUM
admet-341	114	84	20	20	NUM
admet-341	114	85	%	%	NOUN
admet-341	114	86	v	v	ADP
admet-341	114	87	/	/	SYM
admet-341	114	88	v	v	NOUN
admet-341	114	89	peg	peg	NOUN
admet-341	114	90	400	400	NUM
admet-341	114	91	+10	+10	NOUN
admet-341	114	92	%	%	NOUN
admet-341	114	93	w	w	NOUN
admet-341	114	94	/	/	SYM
admet-341	114	95	v	v	NOUN
admet-341	114	96	solutol	solutol	NOUN
admet-341	114	97	hs	hs	PROPN
admet-341	114	98	15	15	NUM
admet-341	114	99	+	+	NUM
admet-341	114	100	10	10	NUM
admet-341	114	101	%	%	NOUN
admet-341	114	102	w	w	NOUN
admet-341	114	103	/	/	SYM
admet-341	114	104	v	v	NOUN
admet-341	114	105	poloxamer	poloxamer	NOUN
admet-341	114	106	188	188	NUM
admet-341	114	107	+	+	ADJ
admet-341	114	108	purified	purified	ADJ
admet-341	114	109	water	water	NOUN
admet-341	114	110	q.s	q.s	PROPN
admet-341	114	111	.	.	PUNCT
admet-341	114	112	precipitation	precipitation	NOUN
admet-341	114	113	after	after	ADP
admet-341	114	114	48h	48h	PROPN
admet-341	114	115	c	c	PROPN
admet-341	114	116	20	20	NUM
admet-341	114	117	%	%	NOUN
admet-341	114	118	v	v	ADP
admet-341	114	119	/	/	SYM
admet-341	114	120	v	v	NOUN
admet-341	114	121	nmp	nmp	NOUN
admet-341	114	122	+	+	CCONJ
admet-341	114	123	20	20	NUM
admet-341	114	124	%	%	NOUN
admet-341	114	125	v	v	ADP
admet-341	114	126	/	/	SYM
admet-341	114	127	v	v	NOUN
admet-341	114	128	ethanol+	ethanol+	SYM
admet-341	114	129	20	20	NUM
admet-341	114	130	%	%	NOUN
admet-341	114	131	v	v	ADP
admet-341	114	132	/	/	SYM
admet-341	114	133	v	v	NOUN
admet-341	114	134	peg	peg	NOUN
admet-341	114	135	400	400	NUM
admet-341	114	136	+10	+10	NOUN
admet-341	114	137	%	%	NOUN
admet-341	114	138	w	w	NOUN
admet-341	114	139	/	/	SYM
admet-341	114	140	v	v	NOUN
admet-341	114	141	solutol	solutol	NOUN
admet-341	114	142	hs	hs	PROPN
admet-341	114	143	15	15	NUM
admet-341	114	144	+	+	NUM
admet-341	114	145	10	10	NUM
admet-341	114	146	%	%	NOUN
admet-341	114	147	w	w	NOUN
admet-341	114	148	/	/	SYM
admet-341	114	149	v	v	NUM
admet-341	114	150	tpgs	tpgs	NOUN
admet-341	114	151	+	+	CCONJ
admet-341	114	152	purified	purified	ADJ
admet-341	114	153	water	water	PROPN
admet-341	114	154	q.s	q.s	PROPN
admet-341	114	155	.	.	PUNCT
admet-341	114	156	precipitation	precipitation	NOUN
admet-341	114	157	after	after	ADP
admet-341	114	158	48h	48h	PROPN
admet-341	114	159	d	d	PROPN
admet-341	114	160	20	20	NUM
admet-341	114	161	%	%	NOUN
admet-341	114	162	v	v	ADP
admet-341	114	163	/	/	SYM
admet-341	114	164	v	v	NOUN
admet-341	114	165	nmp	nmp	NOUN
admet-341	114	166	+	+	CCONJ
admet-341	114	167	20	20	NUM
admet-341	114	168	%	%	NOUN
admet-341	114	169	w	w	NOUN
admet-341	114	170	/	/	SYM
admet-341	114	171	v	v	NOUN
admet-341	114	172	glycerin+	glycerin+	NUM
admet-341	114	173	20	20	NUM
admet-341	114	174	%	%	NOUN
admet-341	114	175	v	v	ADP
admet-341	114	176	/	/	SYM
admet-341	114	177	v	v	NOUN
admet-341	114	178	ethanol	ethanol	NOUN
admet-341	114	179	+10	+10	NOUN
admet-341	114	180	%	%	NOUN
admet-341	114	181	w	w	NOUN
admet-341	114	182	/	/	SYM
admet-341	114	183	v	v	NUM
admet-341	114	184	tpgs	tpgs	NOUN
admet-341	114	185	+	+	CCONJ
admet-341	114	186	10	10	NUM
admet-341	114	187	%	%	NOUN
admet-341	114	188	w	w	NOUN
admet-341	114	189	/	/	SYM
admet-341	114	190	v	v	NOUN
admet-341	114	191	poloxamer	poloxamer	NOUN
admet-341	114	192	188	188	NUM
admet-341	114	193	+	+	CCONJ
admet-341	114	194	purified	purified	ADJ
admet-341	114	195	water	water	NOUN
admet-341	114	196	q.s	q.s	PROPN
admet-341	114	197	.	.	PUNCT
admet-341	114	198	precipitation	precipitation	NOUN
admet-341	114	199	after	after	ADP
admet-341	114	200	12h	12h	PROPN
admet-341	114	201	f	f	PROPN
admet-341	114	202	20	20	NUM
admet-341	114	203	%	%	NOUN
admet-341	114	204	v	v	ADP
admet-341	114	205	/	/	SYM
admet-341	114	206	v	v	NOUN
admet-341	114	207	nmp	nmp	NOUN
admet-341	114	208	+	+	CCONJ
admet-341	114	209	10	10	NUM
admet-341	114	210	%	%	NOUN
admet-341	114	211	v	v	ADP
admet-341	114	212	/	/	SYM
admet-341	114	213	v	v	NOUN
admet-341	114	214	dmso	dmso	NOUN
admet-341	114	215	+	+	CCONJ
admet-341	114	216	30	30	NUM
admet-341	114	217	%	%	NOUN
admet-341	114	218	v	v	ADP
admet-341	114	219	/	/	SYM
admet-341	114	220	v	v	NOUN
admet-341	114	221	peg	peg	NOUN
admet-341	114	222	400	400	NUM
admet-341	114	223	+	+	SYM
admet-341	114	224	20	20	NUM
admet-341	114	225	%	%	NOUN
admet-341	114	226	w	w	NOUN
admet-341	114	227	/	/	SYM
admet-341	114	228	v	v	NOUN
admet-341	114	229	cremophor	cremophor	NOUN
admet-341	114	230	el	el	PROPN
admet-341	114	231	+	+	PROPN
admet-341	114	232	+	+	CCONJ
admet-341	114	233	purified	purified	ADJ
admet-341	114	234	water	water	NOUN
admet-341	114	235	q.s	q.s	PROPN
admet-341	114	236	precipitation	precipitation	NOUN
admet-341	114	237	after	after	ADP
admet-341	114	238	24h	24h	X
admet-341	114	239	g	g	PROPN
admet-341	114	240	20	20	NUM
admet-341	114	241	%	%	NOUN
admet-341	114	242	v	v	ADP
admet-341	114	243	/	/	SYM
admet-341	114	244	v	v	NOUN
admet-341	114	245	nmp	nmp	NOUN
admet-341	114	246	+	+	CCONJ
admet-341	114	247	10	10	NUM
admet-341	114	248	%	%	NOUN
admet-341	114	249	v	v	ADP
admet-341	114	250	/	/	SYM
admet-341	114	251	v	v	NOUN
admet-341	114	252	dmso	dmso	NOUN
admet-341	114	253	+	+	CCONJ
admet-341	114	254	30	30	NUM
admet-341	114	255	%	%	NOUN
admet-341	114	256	v	v	ADP
admet-341	114	257	/	/	SYM
admet-341	114	258	v	v	NOUN
admet-341	114	259	peg	peg	NOUN
admet-341	114	260	400	400	NUM
admet-341	114	261	+	+	SYM
admet-341	114	262	10	10	NUM
admet-341	114	263	%	%	NOUN
admet-341	114	264	w	w	NOUN
admet-341	114	265	/	/	SYM
admet-341	114	266	v	v	NOUN
admet-341	114	267	solutol	solutol	NOUN
admet-341	114	268	hs	hs	PROPN
admet-341	114	269	15	15	NUM
admet-341	114	270	+	+	CCONJ
admet-341	114	271	+	+	CCONJ
admet-341	114	272	purified	purified	ADJ
admet-341	114	273	water	water	NOUN
admet-341	114	274	q.s	q.s	PROPN
admet-341	114	275	precipitation	precipitation	NOUN
admet-341	114	276	after	after	SCONJ
admet-341	114	277	48h	48h	NOUN
admet-341	114	278	h	h	NOUN
admet-341	114	279	20	20	NUM
admet-341	114	280	%	%	NOUN
admet-341	114	281	v	v	ADP
admet-341	114	282	/	/	SYM
admet-341	114	283	v	v	NOUN
admet-341	114	284	nmp	nmp	NOUN
admet-341	114	285	+	+	CCONJ
admet-341	114	286	10	10	NUM
admet-341	114	287	%	%	NOUN
admet-341	114	288	v	v	ADP
admet-341	114	289	/	/	SYM
admet-341	114	290	v	v	NOUN
admet-341	114	291	dmso	dmso	NOUN
admet-341	114	292	+	+	CCONJ
admet-341	114	293	30	30	NUM
admet-341	114	294	%	%	NOUN
admet-341	114	295	v	v	ADP
admet-341	114	296	/	/	SYM
admet-341	114	297	v	v	NOUN
admet-341	114	298	peg	peg	NOUN
admet-341	114	299	400	400	NUM
admet-341	114	300	+	+	SYM
admet-341	114	301	20	20	NUM
admet-341	114	302	%	%	NOUN
admet-341	114	303	w	w	NOUN
admet-341	114	304	/	/	SYM
admet-341	114	305	v	v	NUM
admet-341	114	306	tpgs	tpgs	NOUN
admet-341	114	307	+	+	CCONJ
admet-341	114	308	purified	purified	ADJ
admet-341	114	309	water	water	NOUN
admet-341	114	310	q.s	q.s	PROPN
admet-341	114	311	precipitation	precipitation	NOUN
admet-341	114	312	after	after	ADP
admet-341	114	313	48h	48h	NOUN
admet-341	114	314	i	i	PRON
admet-341	114	315	20	20	NUM
admet-341	114	316	%	%	NOUN
admet-341	114	317	v	v	ADP
admet-341	114	318	/	/	SYM
admet-341	114	319	v	v	NOUN
admet-341	114	320	nmp	nmp	NOUN
admet-341	114	321	+	+	CCONJ
admet-341	114	322	10	10	NUM
admet-341	114	323	%	%	NOUN
admet-341	114	324	v	v	ADP
admet-341	114	325	/	/	SYM
admet-341	114	326	v	v	NOUN
admet-341	114	327	dmso	dmso	NOUN
admet-341	114	328	+	+	CCONJ
admet-341	114	329	30	30	NUM
admet-341	114	330	%	%	NOUN
admet-341	114	331	v	v	ADP
admet-341	114	332	/	/	SYM
admet-341	114	333	v	v	NOUN
admet-341	114	334	peg	peg	NOUN
admet-341	114	335	400	400	NUM
admet-341	114	336	+	+	SYM
admet-341	114	337	20	20	NUM
admet-341	114	338	%	%	NOUN
admet-341	114	339	w	w	NOUN
admet-341	114	340	/	/	SYM
admet-341	114	341	v	v	NOUN
admet-341	114	342	poloxamer	poloxamer	NOUN
admet-341	114	343	188	188	NUM
admet-341	114	344	+	+	CCONJ
admet-341	114	345	purified	purified	ADJ
admet-341	114	346	water	water	NOUN
admet-341	114	347	q.s	q.s	PROPN
admet-341	114	348	precipitation	precipitation	NOUN
admet-341	114	349	after	after	ADP
admet-341	114	350	48h	48h	PROPN
admet-341	114	351	j	j	PROPN
admet-341	114	352	20	20	NUM
admet-341	114	353	%	%	NOUN
admet-341	114	354	v	v	ADP
admet-341	114	355	/	/	SYM
admet-341	114	356	v	v	NOUN
admet-341	114	357	nmp	nmp	NOUN
admet-341	114	358	+	+	CCONJ
admet-341	114	359	20	20	NUM
admet-341	114	360	%	%	NOUN
admet-341	114	361	v	v	ADP
admet-341	114	362	/	/	SYM
admet-341	114	363	v	v	NOUN
admet-341	114	364	dmso	dmso	NOUN
admet-341	114	365	+	+	CCONJ
admet-341	114	366	30	30	NUM
admet-341	114	367	%	%	NOUN
admet-341	114	368	v	v	ADP
admet-341	114	369	/	/	SYM
admet-341	114	370	v	v	NOUN
admet-341	114	371	peg	peg	NOUN
admet-341	114	372	400	400	NUM
admet-341	114	373	+	+	SYM
admet-341	114	374	20	20	NUM
admet-341	114	375	%	%	NOUN
admet-341	114	376	v	v	ADP
admet-341	114	377	/	/	SYM
admet-341	114	378	v	v	NOUN
admet-341	114	379	labrasol	labrasol	NOUN
admet-341	114	380	+	+	CCONJ
admet-341	114	381	purified	purified	ADJ
admet-341	114	382	water	water	NOUN
admet-341	114	383	q.s	q.s	PROPN
admet-341	114	384	precipitation	precipitation	NOUN
admet-341	114	385	after	after	ADP
admet-341	114	386	72	72	NUM
admet-341	114	387	h	h	NOUN
admet-341	114	388	k	k	NOUN
admet-341	114	389	20	20	NUM
admet-341	114	390	%	%	NOUN
admet-341	114	391	v	v	ADP
admet-341	114	392	/	/	SYM
admet-341	114	393	v	v	NOUN
admet-341	114	394	dmso	dmso	NOUN
admet-341	114	395	+	+	CCONJ
admet-341	114	396	30	30	NUM
admet-341	114	397	%	%	NOUN
admet-341	114	398	w	w	NOUN
admet-341	114	399	/	/	SYM
admet-341	114	400	v	v	NUM
admet-341	114	401	peg	peg	NOUN
admet-341	114	402	400	400	NUM
admet-341	114	403	+	+	SYM
admet-341	114	404	10	10	NUM
admet-341	114	405	%	%	NOUN
admet-341	114	406	w	w	NOUN
admet-341	114	407	/	/	SYM
admet-341	114	408	v	v	NOUN
admet-341	114	409	solutol	solutol	NOUN
admet-341	114	410	+	+	CCONJ
admet-341	114	411	30	30	NUM
admet-341	114	412	%	%	NOUN
admet-341	114	413	v	v	ADP
admet-341	114	414	/	/	SYM
admet-341	114	415	v	v	NOUN
admet-341	114	416	citrate	citrate	NOUN
admet-341	114	417	buffer	buffer	NOUN
admet-341	114	418	(	(	PUNCT
admet-341	114	419	100	100	NUM
admet-341	114	420	mm	mm	NOUN
admet-341	114	421	)	)	PUNCT
admet-341	114	422	precipitation	precipitation	NOUN
admet-341	114	423	after	after	ADP
admet-341	114	424	1	1	NUM
admet-341	114	425	week	week	NOUN
admet-341	114	426	l	l	NOUN
admet-341	114	427	20	20	NUM
admet-341	114	428	%	%	NOUN
admet-341	114	429	v	v	ADP
admet-341	114	430	/	/	SYM
admet-341	114	431	v	v	NOUN
admet-341	114	432	dmso	dmso	NOUN
admet-341	114	433	+	+	CCONJ
admet-341	114	434	40	40	NUM
admet-341	114	435	%	%	NOUN
admet-341	114	436	w	w	NOUN
admet-341	114	437	/	/	SYM
admet-341	114	438	v	v	NUM
admet-341	114	439	peg	peg	NOUN
admet-341	114	440	400	400	NUM
admet-341	114	441	+	+	SYM
admet-341	114	442	10	10	NUM
admet-341	114	443	%	%	NOUN
admet-341	114	444	w	w	NOUN
admet-341	114	445	/	/	SYM
admet-341	114	446	v	v	NOUN
admet-341	114	447	solutol	solutol	NOUN
admet-341	114	448	+	+	CCONJ
admet-341	114	449	30	30	NUM
admet-341	114	450	%	%	NOUN
admet-341	114	451	v	v	ADP
admet-341	114	452	/	/	SYM
admet-341	114	453	v	v	NOUN
admet-341	114	454	citrate	citrate	NOUN
admet-341	114	455	buffer	buffer	NOUN
admet-341	114	456	(	(	PUNCT
admet-341	114	457	100	100	NUM
admet-341	114	458	mm	mm	NOUN
admet-341	114	459	)	)	PUNCT
admet-341	115	1	no	no	DET
admet-341	115	2	visual	visual	ADJ
admet-341	115	3	precipitation	precipitation	NOUN
admet-341	115	4	up	up	ADP
admet-341	115	5	to	to	PART
admet-341	115	6	2	2	NUM
admet-341	115	7	weeks	week	NOUN
admet-341	115	8	we	we	PRON
admet-341	115	9	observed	observe	VERB
admet-341	115	10	that	that	SCONJ
admet-341	115	11	the	the	DET
admet-341	115	12	solubility	solubility	NOUN
admet-341	115	13	of	of	ADP
admet-341	115	14	gbo-006	gbo-006	NOUN
admet-341	115	15	in	in	ADP
admet-341	115	16	dmso	dmso	NOUN
admet-341	115	17	,	,	PUNCT
admet-341	115	18	a	a	DET
admet-341	115	19	pharmaceutically	pharmaceutically	ADV
admet-341	115	20	acceptable	acceptable	ADJ
admet-341	115	21	strong	strong	ADJ
admet-341	115	22	solubilizing	solubilize	VERB
admet-341	115	23	agent	agent	NOUN
admet-341	115	24	,	,	PUNCT
admet-341	115	25	was	be	AUX
admet-341	115	26	quite	quite	ADV
admet-341	115	27	high	high	ADJ
admet-341	115	28	.	.	PUNCT
admet-341	116	1	hence	hence	ADV
admet-341	116	2	,	,	PUNCT
admet-341	116	3	dmso	dmso	NOUN
admet-341	116	4	was	be	AUX
admet-341	116	5	chosen	choose	VERB
admet-341	116	6	as	as	ADP
admet-341	116	7	the	the	DET
admet-341	116	8	solubilizing	solubilize	VERB
admet-341	116	9	agent	agent	NOUN
admet-341	116	10	in	in	ADP
admet-341	116	11	our	our	PRON
admet-341	116	12	formulation	formulation	NOUN
admet-341	116	13	.	.	PUNCT
admet-341	117	1	the	the	DET
admet-341	117	2	peg	peg	NOUN
admet-341	117	3	400	400	NUM
admet-341	117	4	(	(	PUNCT
admet-341	117	5	at	at	ADP
admet-341	117	6	40	40	NUM
admet-341	117	7	%	%	NOUN
admet-341	117	8	v	v	ADP
admet-341	117	9	/	/	SYM
admet-341	117	10	v	v	NOUN
admet-341	117	11	)	)	PUNCT
admet-341	117	12	was	be	AUX
admet-341	117	13	found	find	VERB
admet-341	117	14	to	to	PART
admet-341	117	15	be	be	AUX
admet-341	117	16	a	a	DET
admet-341	117	17	suitable	suitable	ADJ
admet-341	117	18	additive	additive	NOUN
admet-341	117	19	in	in	ADP
admet-341	117	20	the	the	DET
admet-341	117	21	formulation	formulation	NOUN
admet-341	117	22	,	,	PUNCT
admet-341	117	23	as	as	SCONJ
admet-341	117	24	we	we	PRON
admet-341	117	25	observed	observe	VERB
admet-341	117	26	a	a	DET
admet-341	117	27	clear	clear	ADJ
admet-341	117	28	solution	solution	NOUN
admet-341	117	29	of	of	ADP
admet-341	117	30	high	high	ADJ
admet-341	117	31	miscibility	miscibility	NOUN
admet-341	117	32	and	and	CCONJ
admet-341	117	33	compatibility	compatibility	NOUN
admet-341	117	34	with	with	ADP
admet-341	117	35	water	water	NOUN
admet-341	117	36	.	.	PUNCT
admet-341	118	1	however	however	ADV
admet-341	118	2	,	,	PUNCT
admet-341	118	3	at	at	ADP
admet-341	118	4	a	a	DET
admet-341	118	5	lower	low	ADJ
admet-341	118	6	concentration	concentration	NOUN
admet-341	118	7	of	of	ADP
admet-341	118	8	10	10	NUM
admet-341	118	9	-	-	SYM
admet-341	118	10	30	30	NUM
admet-341	118	11	%	%	NOUN
admet-341	118	12	v	v	ADP
admet-341	118	13	/	/	SYM
admet-341	118	14	v	v	NOUN
admet-341	118	15	,	,	PUNCT
admet-341	118	16	peg	peg	NOUN
admet-341	118	17	400	400	NUM
admet-341	118	18	was	be	AUX
admet-341	118	19	found	find	VERB
admet-341	118	20	to	to	PART
admet-341	118	21	be	be	AUX
admet-341	118	22	insufficient	insufficient	ADJ
admet-341	118	23	to	to	PART
admet-341	118	24	prevent	prevent	VERB
admet-341	118	25	precipitation	precipitation	NOUN
admet-341	118	26	of	of	ADP
admet-341	118	27	free	free	ADJ
admet-341	118	28	gbo-006	gbo-006	NOUN
admet-341	118	29	,	,	PUNCT
admet-341	118	30	observed	observe	VERB
admet-341	118	31	after	after	ADP
admet-341	118	32	24	24	NUM
admet-341	118	33	h.	h.	PROPN
admet-341	118	34	therefore	therefore	ADV
admet-341	118	35	,	,	PUNCT
admet-341	118	36	peg	peg	NOUN
admet-341	118	37	400	400	NUM
admet-341	118	38	was	be	AUX
admet-341	118	39	fixed	fix	VERB
admet-341	118	40	at	at	ADP
admet-341	118	41	a	a	DET
admet-341	118	42	concentration	concentration	NOUN
admet-341	118	43	of	of	ADP
admet-341	118	44	40	40	NUM
admet-341	118	45	%	%	NOUN
admet-341	118	46	v	v	NOUN
admet-341	118	47	/	/	SYM
admet-341	118	48	v.	v.	CCONJ
admet-341	118	49	admet	admet	PROPN
admet-341	118	50	&	&	CCONJ
admet-341	118	51	dmpk	dmpk	PROPN
admet-341	118	52	4(4	4(4	NUM
admet-341	118	53	)	)	PUNCT
admet-341	118	54	(	(	PUNCT
admet-341	118	55	2016	2016	NUM
admet-341	118	56	)	)	PUNCT
admet-341	118	57	314	314	NUM
admet-341	118	58	-	-	SYM
admet-341	118	59	326	326	NUM
admet-341	118	60	pharmacokinetics	pharmacokinetic	NOUN
admet-341	118	61	and	and	CCONJ
admet-341	118	62	efficacy	efficacy	NOUN
admet-341	118	63	of	of	ADP
admet-341	118	64	plk2	plk2	PROPN
admet-341	118	65	inhibitor	inhibitor	NOUN
admet-341	118	66	doi	doi	PROPN
admet-341	118	67	:	:	PUNCT
admet-341	118	68	10.5599	10.5599	NUM
admet-341	118	69	/	/	SYM
admet-341	118	70	admet.4.4.341	admet.4.4.341	NOUN
admet-341	118	71	319	319	NUM
admet-341	118	72	among	among	ADP
admet-341	118	73	the	the	DET
admet-341	118	74	different	different	ADJ
admet-341	118	75	percentage	percentage	NOUN
admet-341	118	76	compositions	composition	NOUN
admet-341	118	77	of	of	ADP
admet-341	118	78	the	the	DET
admet-341	118	79	nonionic	nonionic	ADJ
admet-341	118	80	surfactants	surfactant	NOUN
admet-341	118	81	considered	consider	VERB
admet-341	118	82	,	,	PUNCT
admet-341	118	83	including	include	VERB
admet-341	118	84	tween	tween	NOUN
admet-341	118	85	80	80	NUM
admet-341	118	86	,	,	PUNCT
admet-341	118	87	cremophor	cremophor	NOUN
admet-341	118	88	,	,	PUNCT
admet-341	118	89	labrasol	labrasol	NOUN
admet-341	118	90	,	,	PUNCT
admet-341	118	91	transcutol	transcutol	ADJ
admet-341	118	92	and	and	CCONJ
admet-341	118	93	solutol	solutol	ADJ
admet-341	118	94	,	,	PUNCT
admet-341	118	95	the	the	DET
admet-341	118	96	latter	latter	ADJ
admet-341	118	97	surfactant	surfactant	NOUN
admet-341	118	98	was	be	AUX
admet-341	118	99	picked	pick	VERB
admet-341	118	100	as	as	ADP
admet-341	118	101	an	an	DET
admet-341	118	102	ingredient	ingredient	NOUN
admet-341	118	103	in	in	ADP
admet-341	118	104	the	the	DET
admet-341	118	105	optimal	optimal	ADJ
admet-341	118	106	formulation	formulation	NOUN
admet-341	118	107	at	at	ADP
admet-341	118	108	a	a	DET
admet-341	118	109	concentration	concentration	NOUN
admet-341	118	110	of	of	ADP
admet-341	118	111	10	10	NUM
admet-341	118	112	%	%	NOUN
admet-341	118	113	w	w	NOUN
admet-341	118	114	/	/	SYM
admet-341	119	1	v.	v.	ADP
admet-341	119	2	this	this	PRON
admet-341	119	3	was	be	AUX
admet-341	119	4	purely	purely	ADV
admet-341	119	5	based	base	VERB
admet-341	119	6	on	on	ADP
admet-341	119	7	the	the	DET
admet-341	119	8	solubility	solubility	NOUN
admet-341	119	9	,	,	PUNCT
admet-341	119	10	clarity	clarity	NOUN
admet-341	119	11	and	and	CCONJ
admet-341	119	12	miscibility	miscibility	NOUN
admet-341	119	13	of	of	ADP
admet-341	119	14	solutol	solutol	NOUN
admet-341	119	15	at	at	ADP
admet-341	119	16	this	this	DET
admet-341	119	17	concentration	concentration	NOUN
admet-341	119	18	with	with	ADP
admet-341	119	19	the	the	DET
admet-341	119	20	rest	rest	NOUN
admet-341	119	21	of	of	ADP
admet-341	119	22	the	the	DET
admet-341	119	23	additives	additive	NOUN
admet-341	119	24	in	in	ADP
admet-341	119	25	the	the	DET
admet-341	119	26	formulation	formulation	NOUN
admet-341	119	27	.	.	PUNCT
admet-341	120	1	it	it	PRON
admet-341	120	2	was	be	AUX
admet-341	120	3	also	also	ADV
admet-341	120	4	found	find	VERB
admet-341	120	5	that	that	SCONJ
admet-341	120	6	a	a	DET
admet-341	120	7	percentage	percentage	NOUN
admet-341	120	8	concentration	concentration	NOUN
admet-341	120	9	of	of	ADP
admet-341	120	10	5	5	NUM
admet-341	120	11	%	%	NOUN
admet-341	120	12	w	w	NOUN
admet-341	120	13	/	/	SYM
admet-341	120	14	v	v	NOUN
admet-341	120	15	is	be	AUX
admet-341	120	16	insufficient	insufficient	ADJ
admet-341	120	17	to	to	PART
admet-341	120	18	prevent	prevent	VERB
admet-341	120	19	the	the	DET
admet-341	120	20	precipitation	precipitation	NOUN
admet-341	120	21	of	of	ADP
admet-341	120	22	the	the	DET
admet-341	120	23	free	free	ADJ
admet-341	120	24	gbo-006	gbo-006	NOUN
admet-341	120	25	.	.	PUNCT
admet-341	121	1	hence	hence	ADV
admet-341	121	2	,	,	PUNCT
admet-341	121	3	we	we	PRON
admet-341	121	4	decided	decide	VERB
admet-341	121	5	to	to	PART
admet-341	121	6	optimize	optimize	VERB
admet-341	121	7	the	the	DET
admet-341	121	8	formulation	formulation	NOUN
admet-341	121	9	with	with	ADP
admet-341	121	10	at	at	ADP
admet-341	121	11	a	a	DET
admet-341	121	12	percentage	percentage	NOUN
admet-341	121	13	concentration	concentration	NOUN
admet-341	121	14	of	of	ADP
admet-341	121	15	10	10	NUM
admet-341	121	16	%	%	NOUN
admet-341	121	17	w	w	PROPN
admet-341	121	18	/	/	SYM
admet-341	121	19	v.	v.	PROPN
admet-341	121	20	lc	lc	PROPN
admet-341	121	21	-	-	PUNCT
admet-341	121	22	ms	ms	PROPN
admet-341	121	23	/	/	SYM
admet-341	121	24	ms	ms	PROPN
admet-341	121	25	analytical	analytical	ADJ
admet-341	121	26	method	method	NOUN
admet-341	121	27	no	no	DET
admet-341	121	28	interfering	interfere	VERB
admet-341	121	29	peaks	peak	NOUN
admet-341	121	30	were	be	AUX
admet-341	121	31	observed	observe	VERB
admet-341	121	32	in	in	ADP
admet-341	121	33	blank	blank	ADJ
admet-341	121	34	plasma	plasma	NOUN
admet-341	121	35	chromatograms	chromatogram	NOUN
admet-341	121	36	at	at	ADP
admet-341	121	37	gbo-006	gbo-006	NOUN
admet-341	121	38	retention	retention	NOUN
admet-341	121	39	time	time	NOUN
admet-341	121	40	(	(	PUNCT
admet-341	121	41	figure	figure	NOUN
admet-341	121	42	2	2	NUM
admet-341	121	43	)	)	PUNCT
admet-341	121	44	.	.	PUNCT
admet-341	122	1	the	the	DET
admet-341	122	2	retention	retention	NOUN
admet-341	122	3	times	time	NOUN
admet-341	122	4	for	for	ADP
admet-341	122	5	gbo-006	gbo-006	NOUN
admet-341	122	6	and	and	CCONJ
admet-341	122	7	internal	internal	ADJ
admet-341	122	8	standard	standard	NOUN
admet-341	122	9	were	be	AUX
admet-341	122	10	1.58	1.58	NUM
admet-341	122	11	and	and	CCONJ
admet-341	122	12	1.80	1.80	NUM
admet-341	122	13	min	min	NOUN
admet-341	122	14	,	,	PUNCT
admet-341	122	15	respectively	respectively	ADV
admet-341	122	16	.	.	PUNCT
admet-341	123	1	the	the	DET
admet-341	123	2	calibration	calibration	NOUN
admet-341	123	3	curves	curve	NOUN
admet-341	123	4	and	and	CCONJ
admet-341	123	5	linearity	linearity	NOUN
admet-341	123	6	was	be	AUX
admet-341	123	7	determined	determine	VERB
admet-341	123	8	using	use	VERB
admet-341	123	9	weighted	weight	VERB
admet-341	123	10	(	(	PUNCT
admet-341	123	11	1	1	NUM
admet-341	123	12	/	/	SYM
admet-341	123	13	x2	x2	ADJ
admet-341	123	14	)	)	PUNCT
admet-341	123	15	linear	linear	ADJ
admet-341	123	16	regression	regression	NOUN
admet-341	123	17	analysis	analysis	NOUN
admet-341	123	18	in	in	ADP
admet-341	123	19	the	the	DET
admet-341	123	20	following	follow	VERB
admet-341	123	21	ranges	range	NOUN
admet-341	123	22	of	of	ADP
admet-341	123	23	1	1	NUM
admet-341	123	24	to	to	ADP
admet-341	123	25	1000	1000	NUM
admet-341	123	26	ng	ng	NOUN
admet-341	123	27	/	/	SYM
admet-341	123	28	ml	ml	X
admet-341	123	29	in	in	ADP
admet-341	123	30	rat	rat	NOUN
admet-341	123	31	,	,	PUNCT
admet-341	123	32	mouse	mouse	NOUN
admet-341	123	33	and	and	CCONJ
admet-341	123	34	dog	dog	NOUN
admet-341	123	35	plasma	plasma	NOUN
admet-341	123	36	.	.	PUNCT
admet-341	124	1	the	the	DET
admet-341	124	2	correlation	correlation	NOUN
admet-341	124	3	coefficients	coefficient	NOUN
admet-341	124	4	were	be	AUX
admet-341	124	5	>	>	X
admet-341	124	6	0.995	0.995	NUM
admet-341	124	7	for	for	ADP
admet-341	124	8	calibration	calibration	NOUN
admet-341	124	9	curves	curve	NOUN
admet-341	124	10	.	.	PUNCT
admet-341	125	1	the	the	DET
admet-341	125	2	batch	batch	NOUN
admet-341	125	3	was	be	AUX
admet-341	125	4	accepted	accept	VERB
admet-341	125	5	once	once	ADV
admet-341	125	6	the	the	DET
admet-341	125	7	low	low	ADJ
admet-341	125	8	,	,	PUNCT
admet-341	125	9	medium	medium	ADJ
admet-341	125	10	and	and	CCONJ
admet-341	125	11	high	high	ADJ
admet-341	125	12	quality	quality	NOUN
admet-341	125	13	control	control	NOUN
admet-341	125	14	(	(	PUNCT
admet-341	125	15	qc	qc	PROPN
admet-341	125	16	)	)	PUNCT
admet-341	125	17	samples	sample	NOUN
admet-341	125	18	and	and	CCONJ
admet-341	125	19	standard	standard	ADJ
admet-341	125	20	samples	sample	NOUN
admet-341	125	21	met	meet	VERB
admet-341	125	22	the	the	DET
admet-341	125	23	acceptance	acceptance	NOUN
admet-341	125	24	criteria	criterion	NOUN
admet-341	125	25	.	.	PUNCT
admet-341	126	1	pharmacokinetics	pharmacokinetic	NOUN
admet-341	126	2	in	in	ADP
admet-341	126	3	rats	rat	NOUN
admet-341	126	4	a	a	DET
admet-341	126	5	plasma	plasma	NOUN
admet-341	126	6	concentration	concentration	NOUN
admet-341	126	7	and	and	CCONJ
admet-341	126	8	time	time	NOUN
admet-341	126	9	profile	profile	NOUN
admet-341	126	10	of	of	ADP
admet-341	126	11	gbo-006	gbo-006	NOUN
admet-341	126	12	obtained	obtain	VERB
admet-341	126	13	is	be	AUX
admet-341	126	14	shown	show	VERB
admet-341	126	15	in	in	ADP
admet-341	126	16	figure	figure	NOUN
admet-341	126	17	3	3	NUM
admet-341	126	18	and	and	CCONJ
admet-341	126	19	corresponding	corresponding	ADJ
admet-341	126	20	pharmacokinetic	pharmacokinetic	ADJ
admet-341	126	21	parameters	parameter	NOUN
admet-341	126	22	are	be	AUX
admet-341	126	23	shown	show	VERB
admet-341	126	24	in	in	ADP
admet-341	126	25	table	table	NOUN
admet-341	126	26	2	2	NUM
admet-341	126	27	.	.	PUNCT
admet-341	127	1	after	after	ADP
admet-341	127	2	intravenous	intravenous	ADJ
admet-341	127	3	bolus	bolus	ADJ
admet-341	127	4	injection	injection	NOUN
admet-341	127	5	,	,	PUNCT
admet-341	127	6	the	the	DET
admet-341	127	7	plasma	plasma	NOUN
admet-341	127	8	concentrations	concentration	NOUN
admet-341	127	9	declined	decline	VERB
admet-341	127	10	by	by	ADP
admet-341	127	11	99	99	NUM
admet-341	127	12	%	%	NOUN
admet-341	127	13	over	over	ADP
admet-341	127	14	the	the	DET
admet-341	127	15	first	first	ADJ
admet-341	127	16	4h	4h	NUM
admet-341	127	17	.	.	PUNCT
admet-341	128	1	gbo-006	gbo-006	PROPN
admet-341	128	2	showed	show	VERB
admet-341	128	3	moderate	moderate	ADJ
admet-341	128	4	clearance	clearance	NOUN
admet-341	128	5	(	(	PUNCT
admet-341	128	6	equivalent	equivalent	ADJ
admet-341	128	7	to	to	ADP
admet-341	128	8	55	55	NUM
admet-341	128	9	%	%	NOUN
admet-341	128	10	of	of	ADP
admet-341	128	11	rat	rat	NOUN
admet-341	128	12	hepatic	hepatic	ADJ
admet-341	128	13	blood	blood	NOUN
admet-341	128	14	flow	flow	NOUN
admet-341	128	15	)	)	PUNCT
admet-341	128	16	with	with	ADP
admet-341	128	17	half	half	ADJ
admet-341	128	18	-	-	PUNCT
admet-341	128	19	life	life	NOUN
admet-341	128	20	of	of	ADP
admet-341	128	21	0.6	0.6	NUM
admet-341	128	22	h	h	NOUN
admet-341	128	23	and	and	CCONJ
admet-341	128	24	extra	extra	ADJ
admet-341	128	25	vascular	vascular	ADJ
admet-341	128	26	distribution	distribution	NOUN
admet-341	128	27	.	.	PUNCT
admet-341	129	1	it	it	PRON
admet-341	129	2	showed	show	VERB
admet-341	129	3	poor	poor	ADJ
admet-341	129	4	oral	oral	ADJ
admet-341	129	5	bioavailability	bioavailability	NOUN
admet-341	129	6	.	.	PUNCT
admet-341	130	1	pharmacokinetics	pharmacokinetic	NOUN
admet-341	130	2	in	in	ADP
admet-341	130	3	mice	mouse	NOUN
admet-341	130	4	following	follow	VERB
admet-341	130	5	iv	iv	NUM
admet-341	130	6	and	and	CCONJ
admet-341	130	7	po	po	PROPN
admet-341	130	8	administration	administration	PROPN
admet-341	130	9	in	in	ADP
admet-341	130	10	mouse	mouse	PROPN
admet-341	130	11	,	,	PUNCT
admet-341	130	12	gbo-006	gbo-006	NOUN
admet-341	130	13	showed	show	VERB
admet-341	130	14	high	high	ADJ
admet-341	130	15	clearance	clearance	NOUN
admet-341	130	16	(	(	PUNCT
admet-341	130	17	77	77	NUM
admet-341	130	18	ml	ml	NOUN
admet-341	130	19	/	/	SYM
admet-341	130	20	min	min	NOUN
admet-341	130	21	/	/	SYM
admet-341	130	22	kg	kg	PROPN
admet-341	130	23	,	,	PUNCT
admet-341	130	24	equivalent	equivalent	ADJ
admet-341	130	25	to	to	ADP
admet-341	130	26	85	85	NUM
admet-341	130	27	%	%	NOUN
admet-341	130	28	of	of	ADP
admet-341	130	29	mouse	mouse	NOUN
admet-341	130	30	hepatic	hepatic	ADJ
admet-341	130	31	blood	blood	NOUN
admet-341	130	32	flow	flow	NOUN
admet-341	130	33	)	)	PUNCT
admet-341	130	34	,	,	PUNCT
admet-341	130	35	short	short	ADJ
admet-341	130	36	terminal	terminal	ADJ
admet-341	130	37	half	half	ADJ
admet-341	130	38	-	-	PUNCT
admet-341	130	39	life	life	NOUN
admet-341	130	40	(	(	PUNCT
admet-341	130	41	0.5	0.5	NUM
admet-341	130	42	h	h	NOUN
admet-341	130	43	)	)	PUNCT
admet-341	130	44	and	and	CCONJ
admet-341	130	45	poor	poor	ADJ
admet-341	130	46	oral	oral	ADJ
admet-341	130	47	bioavailability	bioavailability	NOUN
admet-341	130	48	(	(	PUNCT
admet-341	130	49	table	table	NOUN
admet-341	130	50	3	3	NUM
admet-341	130	51	)	)	PUNCT
admet-341	130	52	.	.	PUNCT
admet-341	131	1	similar	similar	ADJ
admet-341	131	2	to	to	ADP
admet-341	131	3	rat	rat	VERB
admet-341	131	4	,	,	PUNCT
admet-341	131	5	after	after	ADP
admet-341	131	6	intravenous	intravenous	ADJ
admet-341	131	7	bolus	bolus	ADJ
admet-341	131	8	injection	injection	NOUN
admet-341	131	9	the	the	DET
admet-341	131	10	plasma	plasma	NOUN
admet-341	131	11	concentrations	concentration	NOUN
admet-341	131	12	declined	decline	VERB
admet-341	131	13	by	by	ADP
admet-341	131	14	99	99	NUM
admet-341	131	15	%	%	NOUN
admet-341	131	16	over	over	ADP
admet-341	131	17	the	the	DET
admet-341	131	18	first	first	ADJ
admet-341	131	19	4	4	NUM
admet-341	131	20	h	h	NOUN
admet-341	131	21	(	(	PUNCT
admet-341	131	22	figure	figure	NOUN
admet-341	131	23	4	4	NUM
admet-341	131	24	)	)	PUNCT
admet-341	131	25	.	.	PUNCT
admet-341	132	1	dose	dose	VERB
admet-341	132	2	dependent	dependent	ADJ
admet-341	132	3	pharmacokinetic	pharmacokinetic	ADJ
admet-341	132	4	parameters	parameter	NOUN
admet-341	132	5	following	follow	VERB
admet-341	132	6	ip	ip	DET
admet-341	132	7	administration	administration	NOUN
admet-341	132	8	at	at	ADP
admet-341	132	9	three	three	NUM
admet-341	132	10	different	different	ADJ
admet-341	132	11	dose	dose	NOUN
admet-341	132	12	levels	level	NOUN
admet-341	132	13	are	be	AUX
admet-341	132	14	listed	list	VERB
admet-341	132	15	in	in	ADP
admet-341	132	16	table	table	NOUN
admet-341	132	17	4	4	NUM
admet-341	132	18	.	.	PUNCT
admet-341	133	1	as	as	SCONJ
admet-341	133	2	the	the	DET
admet-341	133	3	dose	dose	NOUN
admet-341	133	4	increased	increase	VERB
admet-341	133	5	from	from	ADP
admet-341	133	6	1	1	NUM
admet-341	133	7	to	to	ADP
admet-341	133	8	3	3	NUM
admet-341	133	9	,	,	PUNCT
admet-341	133	10	7.5	7.5	NUM
admet-341	133	11	and	and	CCONJ
admet-341	133	12	10	10	NUM
admet-341	133	13	fold	fold	ADJ
admet-341	133	14	,	,	PUNCT
admet-341	133	15	the	the	DET
admet-341	133	16	area	area	NOUN
admet-341	133	17	under	under	ADP
admet-341	133	18	the	the	DET
admet-341	133	19	curve	curve	NOUN
admet-341	133	20	of	of	ADP
admet-341	133	21	plasma	plasma	NOUN
admet-341	133	22	concentration	concentration	NOUN
admet-341	133	23	versus	versus	ADP
admet-341	133	24	time	time	NOUN
admet-341	133	25	profile	profile	NOUN
admet-341	133	26	increased	increase	VERB
admet-341	133	27	1	1	NUM
admet-341	133	28	to	to	ADP
admet-341	133	29	,	,	PUNCT
admet-341	133	30	5	5	NUM
admet-341	133	31	,	,	PUNCT
admet-341	133	32	8	8	NUM
admet-341	133	33	and	and	CCONJ
admet-341	133	34	10	10	NUM
admet-341	133	35	fold	fold	ADJ
admet-341	133	36	.	.	PUNCT
admet-341	134	1	as	as	SCONJ
admet-341	134	2	demonstrated	demonstrate	VERB
admet-341	134	3	in	in	ADP
admet-341	134	4	figure	figure	NOUN
admet-341	134	5	5	5	NUM
admet-341	134	6	,	,	PUNCT
admet-341	134	7	gbo-006	gbo-006	ADJ
admet-341	134	8	plasma	plasma	NOUN
admet-341	134	9	concentrations	concentration	NOUN
admet-341	134	10	escalates	escalate	VERB
admet-341	134	11	as	as	SCONJ
admet-341	134	12	the	the	DET
admet-341	134	13	dose	dose	NOUN
admet-341	134	14	increased	increase	VERB
admet-341	134	15	,	,	PUNCT
admet-341	134	16	thus	thus	ADV
admet-341	134	17	displaying	display	VERB
admet-341	134	18	linear	linear	ADJ
admet-341	134	19	pharmacokinetics	pharmacokinetic	NOUN
admet-341	134	20	.	.	PUNCT
admet-341	135	1	srinivas	srinivas	PROPN
admet-341	135	2	maddi	maddi	PROPN
admet-341	135	3	et	et	PROPN
admet-341	135	4	al	al	PROPN
admet-341	135	5	.	.	PROPN
admet-341	135	6	admet	admet	PROPN
admet-341	135	7	&	&	CCONJ
admet-341	135	8	dmpk	dmpk	PROPN
admet-341	135	9	4(4	4(4	NUM
admet-341	135	10	)	)	PUNCT
admet-341	135	11	(	(	PUNCT
admet-341	135	12	2016	2016	NUM
admet-341	135	13	)	)	PUNCT
admet-341	135	14	314	314	NUM
admet-341	135	15	-	-	SYM
admet-341	135	16	326	326	NUM
admet-341	135	17	320	320	NUM
admet-341	135	18	figure	figure	NOUN
admet-341	135	19	2	2	NUM
admet-341	135	20	.	.	PUNCT
admet-341	135	21	representative	representative	PROPN
admet-341	135	22	mrm	mrm	PROPN
admet-341	135	23	chromatograms	chromatogram	NOUN
admet-341	135	24	of	of	ADP
admet-341	135	25	gbo-006	gbo-006	NOUN
admet-341	135	26	obtained	obtain	VERB
admet-341	135	27	from	from	ADP
admet-341	135	28	blank	blank	ADJ
admet-341	135	29	plasma	plasma	NOUN
admet-341	135	30	sample	sample	NOUN
admet-341	135	31	(	(	PUNCT
admet-341	135	32	a	a	NOUN
admet-341	135	33	)	)	PUNCT
admet-341	135	34	and	and	CCONJ
admet-341	135	35	calibration	calibration	NOUN
admet-341	135	36	standard	standard	ADJ
admet-341	135	37	plasma	plasma	NOUN
admet-341	135	38	sample	sample	NOUN
admet-341	135	39	of	of	ADP
admet-341	135	40	1	1	NUM
admet-341	135	41	ng	ng	PROPN
admet-341	135	42	/	/	SYM
admet-341	135	43	ml	ml	PROPN
admet-341	135	44	,	,	PUNCT
admet-341	135	45	lloq	lloq	PROPN
admet-341	135	46	(	(	PUNCT
admet-341	135	47	b	b	NOUN
admet-341	135	48	)	)	PUNCT
admet-341	135	49	.	.	PUNCT
admet-341	136	1	figure	figure	VERB
admet-341	136	2	3	3	NUM
admet-341	136	3	.	.	PUNCT
admet-341	137	1	mean	mean	VERB
admet-341	137	2	plasma	plasma	NOUN
admet-341	137	3	concentration	concentration	NOUN
admet-341	137	4	vs.	vs.	ADP
admet-341	137	5	time	time	NOUN
admet-341	137	6	curve	curve	NOUN
admet-341	137	7	of	of	ADP
admet-341	137	8	gbo-006	gbo-006	NOUN
admet-341	137	9	following	follow	VERB
admet-341	137	10	its	its	PRON
admet-341	137	11	intravenous	intravenous	ADJ
admet-341	137	12	and	and	CCONJ
admet-341	137	13	oral	oral	ADJ
admet-341	137	14	administration	administration	NOUN
admet-341	137	15	in	in	ADP
admet-341	137	16	male	male	ADJ
admet-341	137	17	sprague	sprague	PROPN
admet-341	137	18	dawley	dawley	NOUN
admet-341	137	19	rat	rat	PROPN
admet-341	137	20	.	.	PUNCT
admet-341	138	1	each	each	DET
admet-341	138	2	point	point	NOUN
admet-341	138	3	(	(	PUNCT
admet-341	138	4	n=3	n=3	NOUN
admet-341	138	5	)	)	PUNCT
admet-341	138	6	represents	represent	VERB
admet-341	138	7	the	the	DET
admet-341	138	8	mean	mean	ADJ
admet-341	138	9	±	±	NUM
admet-341	138	10	sd	sd	NOUN
admet-341	138	11	.	.	PUNCT
admet-341	139	1	sample	sample	NOUN
admet-341	139	2	name	name	NOUN
admet-341	139	3	:	:	PUNCT
admet-341	139	4	"	"	PUNCT
admet-341	139	5	bl	bl	INTJ
admet-341	139	6	"	"	PUNCT
admet-341	139	7	sample	sample	NOUN
admet-341	139	8	i	i	PROPN
admet-341	139	9	d	d	PROPN
admet-341	139	10	:	:	PUNCT
admet-341	139	11	"	"	PUNCT
admet-341	139	12	"	"	PUNCT
admet-341	139	13	file	file	NOUN
admet-341	139	14	:	:	PUNCT
admet-341	139	15	"	"	PUNCT
admet-341	139	16	001.wiff	001.wiff	NOUN
admet-341	139	17	"	"	PUNCT
admet-341	139	18	peak	peak	NOUN
admet-341	139	19	name	name	NOUN
admet-341	139	20	:	:	PUNCT
admet-341	139	21	"	"	PUNCT
admet-341	139	22	gbo-0061	gbo-0061	NOUN
admet-341	139	23	"	"	PUNCT
admet-341	139	24	mass(es	mass(es	NOUN
admet-341	139	25	):	):	PUNCT
admet-341	139	26	"	"	PUNCT
admet-341	139	27	468.200/290.200	468.200/290.200	NUM
admet-341	139	28	da	da	NOUN
admet-341	139	29	"	"	PUNCT
admet-341	139	30	comment	comment	NOUN
admet-341	139	31	:	:	PUNCT
admet-341	139	32	"	"	PUNCT
admet-341	139	33	"	"	PUNCT
admet-341	139	34	annotation	annotation	NOUN
admet-341	139	35	:	:	PUNCT
admet-341	139	36	"	"	PUNCT
admet-341	139	37	"	"	PUNCT
admet-341	139	38	sample	sample	NOUN
admet-341	139	39	index	index	NOUN
admet-341	139	40	:	:	PUNCT
admet-341	139	41	3	3	NUM
admet-341	139	42	sample	sample	NOUN
admet-341	139	43	type	type	NOUN
admet-341	139	44	:	:	PUNCT
admet-341	139	45	unknown	unknown	ADJ
admet-341	139	46	concentration	concentration	NOUN
admet-341	139	47	:	:	PUNCT
admet-341	139	48	n	n	CCONJ
admet-341	139	49	/	/	SYM
admet-341	139	50	a	a	DET
admet-341	139	51	calculated	calculate	VERB
admet-341	139	52	conc	conc	NOUN
admet-341	139	53	:	:	PUNCT
admet-341	139	54	0.00	0.00	NUM
admet-341	139	55	ng	ng	PROPN
admet-341	139	56	/	/	SYM
admet-341	139	57	ml	ml	PROPN
admet-341	139	58	acq	acq	PROPN
admet-341	139	59	.	.	PROPN
admet-341	139	60	date	date	PROPN
admet-341	139	61	:	:	PUNCT
admet-341	139	62	12/2/2016	12/2/2016	NUM
admet-341	139	63	acq	acq	PROPN
admet-341	139	64	.	.	PROPN
admet-341	139	65	time	time	NOUN
admet-341	139	66	:	:	PUNCT
admet-341	140	1	1:14:50	1:14:50	NUM
admet-341	140	2	pm	pm	NOUN
admet-341	140	3	modified	modify	VERB
admet-341	140	4	:	:	PUNCT
admet-341	140	5	no	no	DET
admet-341	140	6	0.2	0.2	NUM
admet-341	140	7	0.4	0.4	NUM
admet-341	140	8	0.6	0.6	NUM
admet-341	140	9	0.8	0.8	NUM
admet-341	140	10	1.0	1.0	NUM
admet-341	140	11	1.2	1.2	NUM
admet-341	140	12	1.4	1.4	NUM
admet-341	140	13	1.6	1.6	NUM
admet-341	140	14	1.8	1.8	NUM
admet-341	140	15	2.0	2.0	NUM
admet-341	140	16	2.2	2.2	NUM
admet-341	140	17	2.4	2.4	NUM
admet-341	140	18	2.6	2.6	NUM
admet-341	140	19	2.8	2.8	NUM
admet-341	140	20	3.0	3.0	NUM
admet-341	140	21	time	time	NOUN
admet-341	140	22	,	,	PUNCT
admet-341	140	23	min	min	NOUN
admet-341	140	24	0	0	NUM
admet-341	140	25	1	1	NUM
admet-341	140	26	2	2	NUM
admet-341	140	27	3	3	NUM
admet-341	140	28	4	4	NUM
admet-341	140	29	5	5	NUM
admet-341	140	30	6	6	NUM
admet-341	140	31	7	7	NUM
admet-341	140	32	8	8	NUM
admet-341	140	33	9	9	NUM
admet-341	140	34	10	10	NUM
admet-341	140	35	11	11	NUM
admet-341	140	36	12	12	NUM
admet-341	140	37	13	13	NUM
admet-341	140	38	14	14	NUM
admet-341	140	39	15	15	NUM
admet-341	140	40	16	16	NUM
admet-341	140	41	17	17	NUM
admet-341	140	42	18	18	NUM
admet-341	140	43	19	19	NUM
admet-341	140	44	20	20	NUM
admet-341	140	45	21	21	NUM
admet-341	140	46	22	22	NUM
admet-341	140	47	23	23	NUM
admet-341	140	48	24	24	NUM
admet-341	140	49	25	25	NUM
admet-341	140	50	26	26	NUM
admet-341	140	51	27	27	NUM
admet-341	140	52	28	28	NUM
admet-341	140	53	29	29	NUM
admet-341	140	54	30	30	NUM
admet-341	140	55	31	31	NUM
admet-341	140	56	32	32	NUM
admet-341	140	57	33	33	NUM
admet-341	140	58	34	34	NUM
admet-341	140	59	35	35	NUM
admet-341	140	60	36	36	NUM
admet-341	140	61	37	37	NUM
admet-341	140	62	38	38	NUM
admet-341	140	63	39	39	NUM
admet-341	140	64	40	40	NUM
admet-341	140	65	41	41	NUM
admet-341	140	66	42	42	NUM
admet-341	140	67	43	43	NUM
admet-341	140	68	44	44	NUM
admet-341	140	69	45	45	NUM
admet-341	140	70	46	46	NUM
admet-341	140	71	47	47	NUM
admet-341	140	72	48	48	NUM
admet-341	140	73	49	49	NUM
admet-341	140	74	50	50	NUM
admet-341	140	75	in	in	ADP
admet-341	140	76	te	te	PROPN
admet-341	140	77	ns	ns	NUM
admet-341	140	78	ity	ity	PROPN
admet-341	140	79	,	,	PUNCT
admet-341	140	80	c	c	NOUN
admet-341	140	81	ps	ps	PROPN
admet-341	140	82	1.57	1.57	NUM
admet-341	140	83	2.54	2.54	NUM
admet-341	140	84	2.68	2.68	NUM
admet-341	140	85	2.792.31	2.792.31	NUM
admet-341	140	86	1.68	1.68	NUM
admet-341	140	87	1.991.90	1.991.90	NUM
admet-341	140	88	2.95	2.95	NUM
admet-341	140	89	2.43	2.43	NUM
admet-341	140	90	2.21	2.21	NUM
admet-341	140	91	2.10	2.10	NUM
admet-341	140	92	1.48	1.48	NUM
admet-341	140	93	0.44	0.44	NUM
admet-341	140	94	1.04	1.04	NUM
admet-341	140	95	0.50	0.50	NUM
admet-341	140	96	0.71	0.71	NUM
admet-341	140	97	sample	sample	NOUN
admet-341	140	98	name	name	NOUN
admet-341	140	99	:	:	PUNCT
admet-341	140	100	"	"	PUNCT
admet-341	140	101	bl	bl	INTJ
admet-341	140	102	"	"	PUNCT
admet-341	140	103	sample	sample	NOUN
admet-341	140	104	i	i	PROPN
admet-341	140	105	d	d	PROPN
admet-341	140	106	:	:	PUNCT
admet-341	140	107	"	"	PUNCT
admet-341	140	108	"	"	PUNCT
admet-341	140	109	file	file	NOUN
admet-341	140	110	:	:	PUNCT
admet-341	140	111	"	"	PUNCT
admet-341	140	112	001.wiff	001.wiff	NOUN
admet-341	140	113	"	"	PUNCT
admet-341	140	114	peak	peak	NOUN
admet-341	140	115	name	name	NOUN
admet-341	140	116	:	:	PUNCT
admet-341	140	117	"	"	PUNCT
admet-341	140	118	telmisartan(is	telmisartan(i	NOUN
admet-341	140	119	)	)	PUNCT
admet-341	140	120	"	"	PUNCT
admet-341	140	121	mass(es	mass(es	NOUN
admet-341	140	122	):	):	PUNCT
admet-341	140	123	"	"	PUNCT
admet-341	140	124	515.400/276.100	515.400/276.100	NUM
admet-341	140	125	da	da	NOUN
admet-341	140	126	"	"	PUNCT
admet-341	140	127	comment	comment	NOUN
admet-341	140	128	:	:	PUNCT
admet-341	140	129	"	"	PUNCT
admet-341	140	130	"	"	PUNCT
admet-341	140	131	annotation	annotation	NOUN
admet-341	140	132	:	:	PUNCT
admet-341	140	133	"	"	PUNCT
admet-341	140	134	"	"	PUNCT
admet-341	140	135	sample	sample	NOUN
admet-341	140	136	index	index	NOUN
admet-341	140	137	:	:	PUNCT
admet-341	140	138	3	3	NUM
admet-341	140	139	sample	sample	NOUN
admet-341	140	140	type	type	NOUN
admet-341	140	141	:	:	PUNCT
admet-341	140	142	unknown	unknown	ADJ
admet-341	140	143	concentration	concentration	NOUN
admet-341	140	144	:	:	PUNCT
admet-341	140	145	1.00	1.00	NUM
admet-341	140	146	ng	ng	NOUN
admet-341	140	147	/	/	SYM
admet-341	140	148	ml	ml	VERB
admet-341	140	149	calculated	calculate	VERB
admet-341	140	150	conc	conc	NOUN
admet-341	140	151	:	:	PUNCT
admet-341	140	152	n	n	CCONJ
admet-341	140	153	/	/	SYM
admet-341	140	154	a	a	DET
admet-341	140	155	acq	acq	PROPN
admet-341	140	156	.	.	PUNCT
admet-341	140	157	date	date	PROPN
admet-341	140	158	:	:	PUNCT
admet-341	140	159	12/2/2016	12/2/2016	NUM
admet-341	140	160	acq	acq	PROPN
admet-341	140	161	.	.	PROPN
admet-341	140	162	time	time	NOUN
admet-341	140	163	:	:	PUNCT
admet-341	140	164	1:14:50	1:14:50	NUM
admet-341	140	165	pm	pm	NOUN
admet-341	140	166	modified	modify	VERB
admet-341	140	167	:	:	PUNCT
admet-341	140	168	no	no	DET
admet-341	140	169	proc	proc	NOUN
admet-341	140	170	.	.	PUNCT
admet-341	141	1	algorithm	algorithm	NOUN
admet-341	141	2	:	:	PUNCT
admet-341	141	3	analyst	analyst	NOUN
admet-341	141	4	classic	classic	ADJ
admet-341	141	5	bunching	bunch	VERB
admet-341	141	6	factor	factor	NOUN
admet-341	141	7	:	:	PUNCT
admet-341	141	8	1	1	NUM
admet-341	141	9	noise	noise	NOUN
admet-341	141	10	threshold	threshold	NOUN
admet-341	141	11	:	:	PUNCT
admet-341	141	12	20.00	20.00	NUM
admet-341	141	13	cps	cp	NOUN
admet-341	141	14	area	area	NOUN
admet-341	141	15	threshold	threshold	NOUN
admet-341	141	16	:	:	PUNCT
admet-341	141	17	100.00	100.00	NUM
admet-341	141	18	cps	cp	NOUN
admet-341	141	19	,	,	PUNCT
admet-341	141	20	num	num	PROPN
admet-341	141	21	.	.	PUNCT
admet-341	141	22	smooths	smooth	NOUN
admet-341	141	23	:	:	PUNCT
admet-341	141	24	4	4	NUM
admet-341	141	25	sep	sep	NOUN
admet-341	141	26	.	.	PUNCT
admet-341	142	1	width	width	PROPN
admet-341	142	2	:	:	PUNCT
admet-341	142	3	0.20	0.20	NUM
admet-341	142	4	sep	sep	NOUN
admet-341	142	5	.	.	PUNCT
admet-341	143	1	height	height	NOUN
admet-341	143	2	:	:	PUNCT
admet-341	144	1	1.00	1.00	NUM
admet-341	144	2	exp	exp	NOUN
admet-341	144	3	.	.	PUNCT
admet-341	144	4	peak	peak	NOUN
admet-341	144	5	ratio	ratio	NOUN
admet-341	144	6	:	:	PUNCT
admet-341	144	7	5.00	5.00	NUM
admet-341	144	8	exp	exp	NOUN
admet-341	144	9	.	.	PUNCT
admet-341	144	10	adj	adj	PROPN
admet-341	144	11	.	.	PROPN
admet-341	144	12	ratio	ratio	NOUN
admet-341	144	13	:	:	PUNCT
admet-341	144	14	4.00	4.00	NUM
admet-341	144	15	exp	exp	NOUN
admet-341	144	16	.	.	PUNCT
admet-341	145	1	val	val	PROPN
admet-341	145	2	.	.	PUNCT
admet-341	146	1	ratio	ratio	NOUN
admet-341	146	2	:	:	PUNCT
admet-341	146	3	3.00	3.00	NUM
admet-341	146	4	rt	rt	NOUN
admet-341	146	5	window	window	NOUN
admet-341	146	6	:	:	PUNCT
admet-341	146	7	30.0	30.0	NUM
admet-341	146	8	sec	sec	PROPN
admet-341	146	9	expected	expect	VERB
admet-341	146	10	rt	rt	NOUN
admet-341	146	11	:	:	PUNCT
admet-341	146	12	1.78	1.78	NUM
admet-341	146	13	min	min	NOUN
admet-341	146	14	use	use	VERB
admet-341	146	15	relative	relative	ADJ
admet-341	146	16	rt	rt	PROPN
admet-341	146	17	:	:	PUNCT
admet-341	146	18	no	no	DET
admet-341	146	19	int	int	NOUN
admet-341	146	20	.	.	PUNCT
admet-341	147	1	type	type	NOUN
admet-341	147	2	:	:	PUNCT
admet-341	147	3	base	base	NOUN
admet-341	147	4	to	to	PART
admet-341	147	5	base	base	VERB
admet-341	147	6	retention	retention	NOUN
admet-341	147	7	time	time	NOUN
admet-341	147	8	:	:	PUNCT
admet-341	147	9	1.82	1.82	NUM
admet-341	147	10	min	min	NOUN
admet-341	147	11	area	area	NOUN
admet-341	147	12	:	:	PUNCT
admet-341	147	13	413742	413742	NUM
admet-341	147	14	counts	count	VERB
admet-341	147	15	height	height	NOUN
admet-341	147	16	:	:	PUNCT
admet-341	147	17	1.32e+005	1.32e+005	NUM
admet-341	147	18	cps	cp	NOUN
admet-341	147	19	start	start	VERB
admet-341	147	20	time	time	NOUN
admet-341	147	21	:	:	PUNCT
admet-341	147	22	1.73	1.73	NUM
admet-341	147	23	min	min	NOUN
admet-341	147	24	end	end	NOUN
admet-341	147	25	time	time	NOUN
admet-341	147	26	:	:	PUNCT
admet-341	147	27	2.01	2.01	NUM
admet-341	147	28	min	min	NOUN
admet-341	147	29	0.2	0.2	NUM
admet-341	147	30	0.4	0.4	NUM
admet-341	147	31	0.6	0.6	NUM
admet-341	147	32	0.8	0.8	NUM
admet-341	147	33	1.0	1.0	NUM
admet-341	147	34	1.2	1.2	NUM
admet-341	147	35	1.4	1.4	NUM
admet-341	147	36	1.6	1.6	NUM
admet-341	147	37	1.8	1.8	NUM
admet-341	147	38	2.0	2.0	NUM
admet-341	147	39	2.2	2.2	NUM
admet-341	147	40	2.4	2.4	NUM
admet-341	147	41	2.6	2.6	NUM
admet-341	147	42	2.8	2.8	NUM
admet-341	147	43	3.0	3.0	NUM
admet-341	147	44	time	time	NOUN
admet-341	147	45	,	,	PUNCT
admet-341	147	46	min	min	PROPN
admet-341	147	47	0.0	0.0	NUM
admet-341	147	48	5000.0	5000.0	NUM
admet-341	147	49	1.0e4	1.0e4	NUM
admet-341	147	50	1.5e4	1.5e4	NUM
admet-341	147	51	2.0e4	2.0e4	NUM
admet-341	147	52	2.5e4	2.5e4	NUM
admet-341	147	53	3.0e4	3.0e4	NUM
admet-341	147	54	3.5e4	3.5e4	NUM
admet-341	147	55	4.0e4	4.0e4	NUM
admet-341	147	56	4.5e4	4.5e4	NUM
admet-341	147	57	5.0e4	5.0e4	NUM
admet-341	147	58	5.5e4	5.5e4	NUM
admet-341	147	59	6.0e4	6.0e4	NUM
admet-341	147	60	6.5e4	6.5e4	NUM
admet-341	147	61	7.0e4	7.0e4	NUM
admet-341	147	62	7.5e4	7.5e4	NUM
admet-341	147	63	8.0e4	8.0e4	NUM
admet-341	147	64	8.5e4	8.5e4	NUM
admet-341	147	65	9.0e4	9.0e4	NUM
admet-341	147	66	9.5e4	9.5e4	NUM
admet-341	147	67	1.0e5	1.0e5	NUM
admet-341	147	68	1.1e5	1.1e5	NUM
admet-341	147	69	1.1e5	1.1e5	NUM
admet-341	147	70	1.2e5	1.2e5	NUM
admet-341	147	71	1.2e5	1.2e5	NUM
admet-341	147	72	1.3e5	1.3e5	NUM
admet-341	147	73	1.3e5	1.3e5	NUM
admet-341	147	74	in	in	ADP
admet-341	147	75	te	te	PROPN
admet-341	147	76	ns	ns	NUM
admet-341	147	77	ity	ity	PROPN
admet-341	147	78	,	,	PUNCT
admet-341	147	79	c	c	NOUN
admet-341	147	80	ps	ps	PROPN
admet-341	147	81	1.82	1.82	NUM
admet-341	147	82	sample	sample	NOUN
admet-341	147	83	name	name	NOUN
admet-341	147	84	:	:	PUNCT
admet-341	147	85	"	"	PUNCT
admet-341	147	86	gbo-006	gbo-006	NOUN
admet-341	147	87	-	-	PUNCT
admet-341	147	88	std1	std1	NOUN
admet-341	147	89	"	"	PUNCT
admet-341	147	90	sample	sample	NOUN
admet-341	147	91	i	i	PROPN
admet-341	147	92	d	d	PROPN
admet-341	147	93	:	:	PUNCT
admet-341	147	94	"	"	PUNCT
admet-341	147	95	"	"	PUNCT
admet-341	147	96	file	file	NOUN
admet-341	147	97	:	:	PUNCT
admet-341	147	98	"	"	PUNCT
admet-341	147	99	001.wiff	001.wiff	NOUN
admet-341	147	100	"	"	PUNCT
admet-341	147	101	peak	peak	NOUN
admet-341	147	102	name	name	NOUN
admet-341	147	103	:	:	PUNCT
admet-341	147	104	"	"	PUNCT
admet-341	147	105	gbo-0061	gbo-0061	NOUN
admet-341	147	106	"	"	PUNCT
admet-341	147	107	mass(es	mass(es	NOUN
admet-341	147	108	):	):	PUNCT
admet-341	147	109	"	"	PUNCT
admet-341	147	110	468.200/290.200	468.200/290.200	NUM
admet-341	147	111	da	da	NOUN
admet-341	147	112	"	"	PUNCT
admet-341	147	113	comment	comment	NOUN
admet-341	147	114	:	:	PUNCT
admet-341	147	115	"	"	PUNCT
admet-341	147	116	"	"	PUNCT
admet-341	147	117	annotation	annotation	NOUN
admet-341	147	118	:	:	PUNCT
admet-341	147	119	"	"	PUNCT
admet-341	147	120	"	"	PUNCT
admet-341	147	121	sample	sample	NOUN
admet-341	147	122	index	index	NOUN
admet-341	147	123	:	:	PUNCT
admet-341	147	124	5	5	NUM
admet-341	147	125	sample	sample	NOUN
admet-341	147	126	type	type	NOUN
admet-341	147	127	:	:	PUNCT
admet-341	147	128	unknown	unknown	ADJ
admet-341	147	129	concentration	concentration	NOUN
admet-341	147	130	:	:	PUNCT
admet-341	147	131	n	n	CCONJ
admet-341	147	132	/	/	SYM
admet-341	147	133	a	a	DET
admet-341	147	134	calculated	calculate	VERB
admet-341	147	135	conc	conc	NOUN
admet-341	147	136	:	:	PUNCT
admet-341	147	137	0.00	0.00	NUM
admet-341	147	138	ng	ng	PROPN
admet-341	147	139	/	/	SYM
admet-341	147	140	ml	ml	PROPN
admet-341	147	141	acq	acq	PROPN
admet-341	147	142	.	.	PROPN
admet-341	147	143	date	date	PROPN
admet-341	147	144	:	:	PUNCT
admet-341	147	145	12/2/2016	12/2/2016	NUM
admet-341	147	146	acq	acq	PROPN
admet-341	147	147	.	.	PROPN
admet-341	147	148	time	time	NOUN
admet-341	147	149	:	:	PUNCT
admet-341	148	1	1:23:22	1:23:22	NUM
admet-341	148	2	pm	pm	NOUN
admet-341	148	3	modified	modify	VERB
admet-341	148	4	:	:	PUNCT
admet-341	148	5	no	no	DET
admet-341	148	6	proc	proc	NOUN
admet-341	148	7	.	.	PUNCT
admet-341	149	1	algorithm	algorithm	NOUN
admet-341	149	2	:	:	PUNCT
admet-341	149	3	analyst	analyst	NOUN
admet-341	149	4	classic	classic	ADJ
admet-341	149	5	bunching	bunch	VERB
admet-341	149	6	factor	factor	NOUN
admet-341	149	7	:	:	PUNCT
admet-341	149	8	1	1	NUM
admet-341	149	9	noise	noise	NOUN
admet-341	149	10	threshold	threshold	NOUN
admet-341	149	11	:	:	PUNCT
admet-341	149	12	20.00	20.00	NUM
admet-341	149	13	cps	cp	NOUN
admet-341	149	14	area	area	NOUN
admet-341	149	15	threshold	threshold	NOUN
admet-341	149	16	:	:	PUNCT
admet-341	149	17	100.00	100.00	NUM
admet-341	149	18	cps	cp	NOUN
admet-341	149	19	,	,	PUNCT
admet-341	149	20	num	num	PROPN
admet-341	149	21	.	.	PUNCT
admet-341	149	22	smooths	smooth	NOUN
admet-341	149	23	:	:	PUNCT
admet-341	149	24	10	10	NUM
admet-341	149	25	sep	sep	NOUN
admet-341	149	26	.	.	PUNCT
admet-341	150	1	width	width	PROPN
admet-341	150	2	:	:	PUNCT
admet-341	150	3	0.20	0.20	NUM
admet-341	150	4	sep	sep	NOUN
admet-341	150	5	.	.	PUNCT
admet-341	151	1	height	height	NOUN
admet-341	151	2	:	:	PUNCT
admet-341	152	1	1.00	1.00	NUM
admet-341	152	2	exp	exp	NOUN
admet-341	152	3	.	.	PUNCT
admet-341	152	4	peak	peak	NOUN
admet-341	152	5	ratio	ratio	NOUN
admet-341	152	6	:	:	PUNCT
admet-341	152	7	5.00	5.00	NUM
admet-341	152	8	exp	exp	NOUN
admet-341	152	9	.	.	PUNCT
admet-341	152	10	adj	adj	PROPN
admet-341	152	11	.	.	PROPN
admet-341	152	12	ratio	ratio	NOUN
admet-341	152	13	:	:	PUNCT
admet-341	152	14	4.00	4.00	NUM
admet-341	152	15	exp	exp	NOUN
admet-341	152	16	.	.	PUNCT
admet-341	153	1	val	val	PROPN
admet-341	153	2	.	.	PUNCT
admet-341	154	1	ratio	ratio	NOUN
admet-341	154	2	:	:	PUNCT
admet-341	154	3	3.00	3.00	NUM
admet-341	154	4	rt	rt	NOUN
admet-341	154	5	window	window	NOUN
admet-341	154	6	:	:	PUNCT
admet-341	154	7	30.0	30.0	NUM
admet-341	154	8	sec	sec	PROPN
admet-341	154	9	expected	expect	VERB
admet-341	154	10	rt	rt	NOUN
admet-341	154	11	:	:	PUNCT
admet-341	154	12	1.57	1.57	NUM
admet-341	154	13	min	min	NOUN
admet-341	154	14	use	use	VERB
admet-341	154	15	relative	relative	ADJ
admet-341	154	16	rt	rt	PROPN
admet-341	154	17	:	:	PUNCT
admet-341	154	18	no	no	DET
admet-341	154	19	int	int	NOUN
admet-341	154	20	.	.	PUNCT
admet-341	155	1	type	type	NOUN
admet-341	155	2	:	:	PUNCT
admet-341	155	3	base	base	NOUN
admet-341	155	4	to	to	PART
admet-341	155	5	base	base	VERB
admet-341	155	6	retention	retention	NOUN
admet-341	155	7	time	time	NOUN
admet-341	155	8	:	:	PUNCT
admet-341	155	9	1.58	1.58	NUM
admet-341	155	10	min	min	NOUN
admet-341	155	11	area	area	NOUN
admet-341	155	12	:	:	PUNCT
admet-341	155	13	2771	2771	NUM
admet-341	155	14	counts	count	VERB
admet-341	155	15	height	height	NOUN
admet-341	155	16	:	:	PUNCT
admet-341	155	17	7.91e+002	7.91e+002	NUM
admet-341	155	18	cps	cp	NOUN
admet-341	155	19	start	start	VERB
admet-341	155	20	time	time	NOUN
admet-341	155	21	:	:	PUNCT
admet-341	155	22	1.51	1.51	NUM
admet-341	155	23	min	min	NOUN
admet-341	155	24	end	end	NOUN
admet-341	155	25	time	time	NOUN
admet-341	155	26	:	:	PUNCT
admet-341	155	27	1.66	1.66	NUM
admet-341	155	28	min	min	NOUN
admet-341	155	29	0.2	0.2	NUM
admet-341	155	30	0.4	0.4	NUM
admet-341	155	31	0.6	0.6	NUM
admet-341	155	32	0.8	0.8	NUM
admet-341	155	33	1.0	1.0	NUM
admet-341	155	34	1.2	1.2	NUM
admet-341	155	35	1.4	1.4	NUM
admet-341	155	36	1.6	1.6	NUM
admet-341	155	37	1.8	1.8	NUM
admet-341	155	38	2.0	2.0	NUM
admet-341	155	39	2.2	2.2	NUM
admet-341	155	40	2.4	2.4	NUM
admet-341	155	41	2.6	2.6	NUM
admet-341	155	42	2.8	2.8	NUM
admet-341	155	43	3.0	3.0	NUM
admet-341	155	44	time	time	NOUN
admet-341	155	45	,	,	PUNCT
admet-341	155	46	min	min	NOUN
admet-341	155	47	0	0	NUM
admet-341	155	48	20	20	NUM
admet-341	155	49	40	40	NUM
admet-341	155	50	60	60	NUM
admet-341	155	51	80	80	NUM
admet-341	155	52	100	100	NUM
admet-341	155	53	120	120	NUM
admet-341	155	54	140	140	NUM
admet-341	155	55	160	160	NUM
admet-341	155	56	180	180	NUM
admet-341	155	57	200	200	NUM
admet-341	155	58	220	220	NUM
admet-341	155	59	240	240	NUM
admet-341	155	60	260	260	NUM
admet-341	155	61	280	280	NUM
admet-341	155	62	300	300	NUM
admet-341	155	63	320	320	NUM
admet-341	155	64	340	340	NUM
admet-341	155	65	360	360	NUM
admet-341	155	66	380	380	NUM
admet-341	155	67	400	400	NUM
admet-341	155	68	420	420	NUM
admet-341	155	69	440	440	NUM
admet-341	155	70	460	460	NUM
admet-341	155	71	480	480	NUM
admet-341	155	72	500	500	NUM
admet-341	155	73	520	520	NUM
admet-341	155	74	540	540	NUM
admet-341	155	75	560	560	NUM
admet-341	155	76	580	580	NUM
admet-341	155	77	600	600	NUM
admet-341	155	78	620	620	NUM
admet-341	155	79	640	640	NUM
admet-341	155	80	660	660	NUM
admet-341	155	81	680	680	NUM
admet-341	155	82	700	700	NUM
admet-341	155	83	720	720	NUM
admet-341	155	84	740	740	NUM
admet-341	155	85	760	760	NUM
admet-341	155	86	780	780	NUM
admet-341	155	87	800	800	NUM
admet-341	155	88	in	in	ADP
admet-341	155	89	te	te	PROPN
admet-341	155	90	ns	ns	NUM
admet-341	155	91	ity	ity	PROPN
admet-341	155	92	,	,	PUNCT
admet-341	155	93	c	c	PROPN
admet-341	155	94	ps	ps	PROPN
admet-341	155	95	1.58	1.58	NUM
admet-341	155	96	sample	sample	NOUN
admet-341	155	97	name	name	NOUN
admet-341	155	98	:	:	PUNCT
admet-341	155	99	"	"	PUNCT
admet-341	155	100	gbo-006	gbo-006	NOUN
admet-341	155	101	-	-	PUNCT
admet-341	155	102	std1	std1	NOUN
admet-341	155	103	"	"	PUNCT
admet-341	155	104	sample	sample	NOUN
admet-341	155	105	i	i	PROPN
admet-341	155	106	d	d	PROPN
admet-341	155	107	:	:	PUNCT
admet-341	155	108	"	"	PUNCT
admet-341	155	109	"	"	PUNCT
admet-341	155	110	file	file	NOUN
admet-341	155	111	:	:	PUNCT
admet-341	155	112	"	"	PUNCT
admet-341	155	113	001.wiff	001.wiff	NOUN
admet-341	155	114	"	"	PUNCT
admet-341	155	115	peak	peak	NOUN
admet-341	155	116	name	name	NOUN
admet-341	155	117	:	:	PUNCT
admet-341	155	118	"	"	PUNCT
admet-341	155	119	telmisartan(is	telmisartan(i	NOUN
admet-341	155	120	)	)	PUNCT
admet-341	155	121	"	"	PUNCT
admet-341	155	122	mass(es	mass(es	NOUN
admet-341	155	123	):	):	PUNCT
admet-341	155	124	"	"	PUNCT
admet-341	155	125	515.400/276.100	515.400/276.100	NUM
admet-341	155	126	da	da	NOUN
admet-341	155	127	"	"	PUNCT
admet-341	155	128	comment	comment	NOUN
admet-341	155	129	:	:	PUNCT
admet-341	155	130	"	"	PUNCT
admet-341	155	131	"	"	PUNCT
admet-341	155	132	annotation	annotation	NOUN
admet-341	155	133	:	:	PUNCT
admet-341	155	134	"	"	PUNCT
admet-341	155	135	"	"	PUNCT
admet-341	155	136	sample	sample	NOUN
admet-341	155	137	index	index	NOUN
admet-341	155	138	:	:	PUNCT
admet-341	155	139	5	5	NUM
admet-341	155	140	sample	sample	NOUN
admet-341	155	141	type	type	NOUN
admet-341	155	142	:	:	PUNCT
admet-341	155	143	unknown	unknown	ADJ
admet-341	155	144	concentration	concentration	NOUN
admet-341	155	145	:	:	PUNCT
admet-341	155	146	1.00	1.00	NUM
admet-341	155	147	ng	ng	NOUN
admet-341	155	148	/	/	SYM
admet-341	155	149	ml	ml	VERB
admet-341	155	150	calculated	calculate	VERB
admet-341	155	151	conc	conc	NOUN
admet-341	155	152	:	:	PUNCT
admet-341	155	153	n	n	CCONJ
admet-341	155	154	/	/	SYM
admet-341	155	155	a	a	DET
admet-341	155	156	acq	acq	PROPN
admet-341	155	157	.	.	PUNCT
admet-341	155	158	date	date	PROPN
admet-341	155	159	:	:	PUNCT
admet-341	155	160	12/2/2016	12/2/2016	NUM
admet-341	155	161	acq	acq	PROPN
admet-341	155	162	.	.	PROPN
admet-341	155	163	time	time	NOUN
admet-341	155	164	:	:	PUNCT
admet-341	156	1	1:23:22	1:23:22	NUM
admet-341	156	2	pm	pm	NOUN
admet-341	156	3	modified	modify	VERB
admet-341	156	4	:	:	PUNCT
admet-341	156	5	no	no	DET
admet-341	156	6	proc	proc	NOUN
admet-341	156	7	.	.	PUNCT
admet-341	157	1	algorithm	algorithm	NOUN
admet-341	157	2	:	:	PUNCT
admet-341	157	3	analyst	analyst	NOUN
admet-341	157	4	classic	classic	ADJ
admet-341	157	5	bunching	bunch	VERB
admet-341	157	6	factor	factor	NOUN
admet-341	157	7	:	:	PUNCT
admet-341	157	8	1	1	NUM
admet-341	157	9	noise	noise	NOUN
admet-341	157	10	threshold	threshold	NOUN
admet-341	157	11	:	:	PUNCT
admet-341	157	12	20.00	20.00	NUM
admet-341	157	13	cps	cp	NOUN
admet-341	157	14	area	area	NOUN
admet-341	157	15	threshold	threshold	NOUN
admet-341	157	16	:	:	PUNCT
admet-341	157	17	100.00	100.00	NUM
admet-341	157	18	cps	cp	NOUN
admet-341	157	19	,	,	PUNCT
admet-341	157	20	num	num	PROPN
admet-341	157	21	.	.	PUNCT
admet-341	157	22	smooths	smooth	NOUN
admet-341	157	23	:	:	PUNCT
admet-341	157	24	4	4	NUM
admet-341	157	25	sep	sep	NOUN
admet-341	157	26	.	.	PUNCT
admet-341	158	1	width	width	PROPN
admet-341	158	2	:	:	PUNCT
admet-341	158	3	0.20	0.20	NUM
admet-341	158	4	sep	sep	NOUN
admet-341	158	5	.	.	PUNCT
admet-341	159	1	height	height	NOUN
admet-341	159	2	:	:	PUNCT
admet-341	160	1	1.00	1.00	NUM
admet-341	160	2	exp	exp	NOUN
admet-341	160	3	.	.	PUNCT
admet-341	160	4	peak	peak	NOUN
admet-341	160	5	ratio	ratio	NOUN
admet-341	160	6	:	:	PUNCT
admet-341	160	7	5.00	5.00	NUM
admet-341	160	8	exp	exp	NOUN
admet-341	160	9	.	.	PUNCT
admet-341	160	10	adj	adj	PROPN
admet-341	160	11	.	.	PROPN
admet-341	160	12	ratio	ratio	NOUN
admet-341	160	13	:	:	PUNCT
admet-341	160	14	4.00	4.00	NUM
admet-341	160	15	exp	exp	NOUN
admet-341	160	16	.	.	PUNCT
admet-341	161	1	val	val	PROPN
admet-341	161	2	.	.	PUNCT
admet-341	162	1	ratio	ratio	NOUN
admet-341	162	2	:	:	PUNCT
admet-341	162	3	3.00	3.00	NUM
admet-341	162	4	rt	rt	NOUN
admet-341	162	5	window	window	NOUN
admet-341	162	6	:	:	PUNCT
admet-341	162	7	30.0	30.0	NUM
admet-341	162	8	sec	sec	PROPN
admet-341	162	9	expected	expect	VERB
admet-341	162	10	rt	rt	NOUN
admet-341	162	11	:	:	PUNCT
admet-341	162	12	1.78	1.78	NUM
admet-341	162	13	min	min	NOUN
admet-341	162	14	use	use	VERB
admet-341	162	15	relative	relative	ADJ
admet-341	162	16	rt	rt	PROPN
admet-341	162	17	:	:	PUNCT
admet-341	162	18	no	no	DET
admet-341	162	19	int	int	NOUN
admet-341	162	20	.	.	PUNCT
admet-341	163	1	type	type	NOUN
admet-341	163	2	:	:	PUNCT
admet-341	163	3	base	base	NOUN
admet-341	163	4	to	to	PART
admet-341	163	5	base	base	VERB
admet-341	163	6	retention	retention	NOUN
admet-341	163	7	time	time	NOUN
admet-341	163	8	:	:	PUNCT
admet-341	163	9	1.80	1.80	NUM
admet-341	163	10	min	min	NOUN
admet-341	163	11	area	area	NOUN
admet-341	163	12	:	:	PUNCT
admet-341	163	13	639887	639887	NUM
admet-341	163	14	counts	count	VERB
admet-341	163	15	height	height	NOUN
admet-341	163	16	:	:	PUNCT
admet-341	163	17	2.05e+005	2.05e+005	NUM
admet-341	163	18	cps	cp	NOUN
admet-341	163	19	start	start	VERB
admet-341	163	20	time	time	NOUN
admet-341	163	21	:	:	PUNCT
admet-341	163	22	1.69	1.69	NUM
admet-341	163	23	min	min	NOUN
admet-341	163	24	end	end	NOUN
admet-341	163	25	time	time	NOUN
admet-341	163	26	:	:	PUNCT
admet-341	163	27	2.07	2.07	NUM
admet-341	163	28	min	min	NOUN
admet-341	163	29	0.2	0.2	NUM
admet-341	163	30	0.4	0.4	NUM
admet-341	163	31	0.6	0.6	NUM
admet-341	163	32	0.8	0.8	NUM
admet-341	163	33	1.0	1.0	NUM
admet-341	163	34	1.2	1.2	NUM
admet-341	163	35	1.4	1.4	NUM
admet-341	163	36	1.6	1.6	NUM
admet-341	163	37	1.8	1.8	NUM
admet-341	163	38	2.0	2.0	NUM
admet-341	163	39	2.2	2.2	NUM
admet-341	163	40	2.4	2.4	NUM
admet-341	163	41	2.6	2.6	NUM
admet-341	163	42	2.8	2.8	NUM
admet-341	163	43	3.0	3.0	NUM
admet-341	163	44	time	time	NOUN
admet-341	163	45	,	,	PUNCT
admet-341	163	46	min	min	PROPN
admet-341	163	47	0.0	0.0	NUM
admet-341	163	48	5000.0	5000.0	NUM
admet-341	163	49	1.0e4	1.0e4	NUM
admet-341	163	50	1.5e4	1.5e4	NUM
admet-341	163	51	2.0e4	2.0e4	NUM
admet-341	163	52	2.5e4	2.5e4	NUM
admet-341	163	53	3.0e4	3.0e4	NUM
admet-341	163	54	3.5e4	3.5e4	NUM
admet-341	163	55	4.0e4	4.0e4	NUM
admet-341	163	56	4.5e4	4.5e4	NUM
admet-341	163	57	5.0e4	5.0e4	NUM
admet-341	163	58	5.5e4	5.5e4	NUM
admet-341	163	59	6.0e4	6.0e4	NUM
admet-341	163	60	6.5e4	6.5e4	NUM
admet-341	163	61	7.0e4	7.0e4	NUM
admet-341	163	62	7.5e4	7.5e4	NUM
admet-341	163	63	8.0e4	8.0e4	NUM
admet-341	163	64	8.5e4	8.5e4	NUM
admet-341	163	65	9.0e4	9.0e4	NUM
admet-341	163	66	9.5e4	9.5e4	NUM
admet-341	163	67	1.0e5	1.0e5	NUM
admet-341	163	68	1.1e5	1.1e5	NUM
admet-341	163	69	1.1e5	1.1e5	NUM
admet-341	163	70	1.2e5	1.2e5	NUM
admet-341	163	71	1.2e5	1.2e5	NUM
admet-341	163	72	1.3e5	1.3e5	NUM
admet-341	163	73	1.3e5	1.3e5	NUM
admet-341	163	74	1.4e5	1.4e5	NUM
admet-341	163	75	1.4e5	1.4e5	NUM
admet-341	163	76	1.5e5	1.5e5	NUM
admet-341	163	77	1.5e5	1.5e5	NUM
admet-341	163	78	1.6e5	1.6e5	NUM
admet-341	163	79	1.6e5	1.6e5	NUM
admet-341	163	80	1.7e5	1.7e5	NUM
admet-341	163	81	1.7e5	1.7e5	NUM
admet-341	163	82	1.8e5	1.8e5	NUM
admet-341	163	83	1.8e5	1.8e5	NUM
admet-341	163	84	1.9e5	1.9e5	NUM
admet-341	163	85	1.9e5	1.9e5	NUM
admet-341	163	86	2.0e5	2.0e5	NUM
admet-341	163	87	2.0e5	2.0e5	NUM
admet-341	163	88	in	in	ADP
admet-341	163	89	te	te	PROPN
admet-341	163	90	ns	ns	NUM
admet-341	163	91	ity	ity	PROPN
admet-341	163	92	,	,	PUNCT
admet-341	163	93	c	c	NOUN
admet-341	163	94	ps	ps	PROPN
admet-341	163	95	1.80	1.80	NUM
admet-341	163	96	1	1	NUM
admet-341	163	97	10	10	NUM
admet-341	163	98	100	100	NUM
admet-341	163	99	1000	1000	NUM
admet-341	163	100	10000	10000	NUM
admet-341	163	101	0	0	NUM
admet-341	163	102	2	2	NUM
admet-341	163	103	4	4	NUM
admet-341	163	104	6	6	NUM
admet-341	163	105	8	8	NUM
admet-341	163	106	10	10	NUM
admet-341	163	107	12	12	NUM
admet-341	163	108	p	p	NOUN
admet-341	163	109	la	la	X
admet-341	163	110	sm	sm	PROPN
admet-341	163	111	a	a	DET
admet-341	163	112	co	co	X
admet-341	163	113	n	n	PROPN
admet-341	163	114	ce	ce	PROPN
admet-341	163	115	n	n	CCONJ
admet-341	163	116	tr	tr	VERB
admet-341	163	117	at	at	ADP
admet-341	163	118	io	io	X
admet-341	163	119	n	n	CCONJ
admet-341	163	120	(	(	PUNCT
admet-341	163	121	n	n	CCONJ
admet-341	163	122	g/	g/	NOUN
admet-341	163	123	m	m	NOUN
admet-341	163	124	l	l	NOUN
admet-341	163	125	)	)	PUNCT
admet-341	163	126	time	time	NOUN
admet-341	163	127	(	(	PUNCT
admet-341	163	128	h	h	NOUN
admet-341	163	129	)	)	PUNCT
admet-341	163	130	iv	iv	NUM
admet-341	163	131	po	po	INTJ
admet-341	163	132	(	(	PUNCT
admet-341	163	133	a	a	NOUN
admet-341	163	134	)	)	PUNCT
admet-341	163	135	(	(	PUNCT
admet-341	163	136	b	b	X
admet-341	163	137	)	)	PUNCT
admet-341	163	138	admet	admet	PROPN
admet-341	163	139	&	&	CCONJ
admet-341	163	140	dmpk	dmpk	PROPN
admet-341	163	141	4(4	4(4	NUM
admet-341	163	142	)	)	PUNCT
admet-341	163	143	(	(	PUNCT
admet-341	163	144	2016	2016	NUM
admet-341	163	145	)	)	PUNCT
admet-341	163	146	314	314	NUM
admet-341	163	147	-	-	SYM
admet-341	163	148	326	326	NUM
admet-341	163	149	pharmacokinetics	pharmacokinetic	NOUN
admet-341	163	150	and	and	CCONJ
admet-341	163	151	efficacy	efficacy	NOUN
admet-341	163	152	of	of	ADP
admet-341	163	153	plk2	plk2	PROPN
admet-341	163	154	inhibitor	inhibitor	NOUN
admet-341	163	155	doi	doi	PROPN
admet-341	163	156	:	:	PUNCT
admet-341	163	157	10.5599	10.5599	NUM
admet-341	163	158	/	/	SYM
admet-341	163	159	admet.4.4.341	admet.4.4.341	NOUN
admet-341	163	160	321	321	NUM
admet-341	163	161	table	table	NOUN
admet-341	163	162	2	2	NUM
admet-341	163	163	.	.	PUNCT
admet-341	163	164	pharmacokinetic	pharmacokinetic	ADJ
admet-341	163	165	parameters	parameter	NOUN
admet-341	163	166	of	of	ADP
admet-341	163	167	gbo-006	gbo-006	NOUN
admet-341	163	168	following	follow	VERB
admet-341	163	169	its	its	PRON
admet-341	163	170	intravenous	intravenous	ADJ
admet-341	163	171	and	and	CCONJ
admet-341	163	172	oral	oral	ADJ
admet-341	163	173	route	route	NOUN
admet-341	163	174	administration	administration	NOUN
admet-341	163	175	in	in	ADP
admet-341	163	176	male	male	ADJ
admet-341	163	177	sprague	sprague	PROPN
admet-341	163	178	dawley	dawley	PROPN
admet-341	163	179	rat	rat	PROPN
admet-341	163	180	.	.	PROPN
admet-341	163	181	data	datum	NOUN
admet-341	163	182	are	be	AUX
admet-341	163	183	expressed	express	VERB
admet-341	163	184	as	as	ADP
admet-341	163	185	mean	mean	NOUN
admet-341	163	186	±	±	NUM
admet-341	163	187	sd	sd	NOUN
admet-341	163	188	in	in	ADP
admet-341	163	189	three	three	NUM
admet-341	163	190	rats	rat	NOUN
admet-341	163	191	.	.	PUNCT
admet-341	164	1	iv	iv	NUM
admet-341	164	2	po	po	PROPN
admet-341	164	3	dose	dose	NOUN
admet-341	164	4	(	(	PUNCT
admet-341	164	5	mg	mg	PROPN
admet-341	164	6	/	/	SYM
admet-341	164	7	kg	kg	NOUN
admet-341	164	8	)	)	PUNCT
admet-341	164	9	1	1	NUM
admet-341	164	10	5	5	NUM
admet-341	164	11	cmax	cmax	NOUN
admet-341	164	12	(	(	PUNCT
admet-341	164	13	ng	ng	NOUN
admet-341	164	14	/	/	SYM
admet-341	164	15	ml	ml	NOUN
admet-341	164	16	)	)	PUNCT
admet-341	164	17	22	22	NUM
admet-341	164	18	tmax(h	tmax(h	NUM
admet-341	164	19	)	)	PUNCT
admet-341	164	20	1	1	NUM
admet-341	164	21	auc0	auc0	NOUN
admet-341	164	22	-	-	PUNCT
admet-341	164	23	24h	24h	NOUN
admet-341	164	24	(	(	PUNCT
admet-341	164	25	ng	ng	PROPN
admet-341	164	26	h	h	PROPN
admet-341	164	27	/ml	/ml	PUNCT
admet-341	164	28	)	)	PUNCT
admet-341	164	29	535	535	NUM
admet-341	164	30	87	87	NUM
admet-341	164	31	dnauc	dnauc	NOUN
admet-341	164	32	535	535	NUM
admet-341	164	33	17	17	NUM
admet-341	164	34	cl	cl	NOUN
admet-341	164	35	(	(	PUNCT
admet-341	164	36	ml	ml	NOUN
admet-341	164	37	/	/	SYM
admet-341	164	38	min	min	NOUN
admet-341	164	39	/	/	SYM
admet-341	164	40	kg	kg	NOUN
admet-341	164	41	)	)	PUNCT
admet-341	164	42	30	30	NUM
admet-341	164	43	thalf	thalf	NOUN
admet-341	164	44	(	(	PUNCT
admet-341	164	45	h	h	NOUN
admet-341	164	46	)	)	PUNCT
admet-341	164	47	0.6	0.6	NUM
admet-341	164	48	vdss	vdss	ADV
admet-341	164	49	(	(	PUNCT
admet-341	164	50	l	l	NOUN
admet-341	164	51	/	/	SYM
admet-341	164	52	kg	kg	NOUN
admet-341	164	53	)	)	PUNCT
admet-341	164	54	1.5	1.5	NUM
admet-341	164	55	mrt	mrt	NOUN
admet-341	164	56	last	last	ADJ
admet-341	164	57	(	(	PUNCT
admet-341	164	58	h	h	NOUN
admet-341	164	59	)	)	PUNCT
admet-341	164	60	0.5	0.5	NUM
admet-341	164	61	bioavailability	bioavailability	NOUN
admet-341	164	62	(	(	PUNCT
admet-341	164	63	%	%	NOUN
admet-341	164	64	f	f	X
admet-341	164	65	)	)	PUNCT
admet-341	164	66	3	3	NUM
admet-341	164	67	figure	figure	NOUN
admet-341	164	68	4	4	NUM
admet-341	164	69	.	.	PUNCT
admet-341	165	1	mean	mean	VERB
admet-341	165	2	plasma	plasma	NOUN
admet-341	165	3	concentration	concentration	NOUN
admet-341	165	4	vs.	vs.	ADP
admet-341	165	5	time	time	NOUN
admet-341	165	6	following	follow	VERB
admet-341	165	7	intravenous	intravenous	ADJ
admet-341	165	8	and	and	CCONJ
admet-341	165	9	oral	oral	ADJ
admet-341	165	10	administration	administration	NOUN
admet-341	165	11	of	of	ADP
admet-341	165	12	gbo-006	gbo-006	NOUN
admet-341	165	13	in	in	ADP
admet-341	165	14	male	male	ADJ
admet-341	165	15	swiss	swiss	ADJ
admet-341	165	16	albino	albino	NOUN
admet-341	165	17	mice	mouse	NOUN
admet-341	165	18	.	.	PUNCT
admet-341	166	1	table	table	NOUN
admet-341	166	2	3	3	NUM
admet-341	166	3	.	.	PUNCT
admet-341	166	4	pharmacokinetic	pharmacokinetic	ADJ
admet-341	166	5	parameters	parameter	NOUN
admet-341	166	6	of	of	ADP
admet-341	166	7	gbo-006	gbo-006	NOUN
admet-341	166	8	following	follow	VERB
admet-341	166	9	its	its	PRON
admet-341	166	10	intravenous	intravenous	ADJ
admet-341	166	11	and	and	CCONJ
admet-341	166	12	oral	oral	ADJ
admet-341	166	13	route	route	NOUN
admet-341	166	14	of	of	ADP
admet-341	166	15	administration	administration	NOUN
admet-341	166	16	in	in	ADP
admet-341	166	17	mouse	mouse	PROPN
admet-341	166	18	.	.	PUNCT
admet-341	167	1	iv	iv	NUM
admet-341	167	2	po	po	PROPN
admet-341	167	3	dose	dose	NOUN
admet-341	167	4	(	(	PUNCT
admet-341	167	5	mg	mg	PROPN
admet-341	167	6	/	/	SYM
admet-341	167	7	kg	kg	NOUN
admet-341	167	8	)	)	PUNCT
admet-341	167	9	2	2	NUM
admet-341	167	10	5	5	NUM
admet-341	167	11	cl	cl	NOUN
admet-341	167	12	(	(	PUNCT
admet-341	167	13	ml	ml	NOUN
admet-341	167	14	/	/	SYM
admet-341	167	15	min	min	NOUN
admet-341	167	16	/	/	SYM
admet-341	167	17	kg	kg	NOUN
admet-341	167	18	)	)	PUNCT
admet-341	167	19	77	77	NUM
admet-341	167	20	thalf	thalf	NOUN
admet-341	167	21	(	(	PUNCT
admet-341	167	22	h	h	NOUN
admet-341	167	23	)	)	PUNCT
admet-341	167	24	0.5	0.5	NUM
admet-341	167	25	vdss	vdss	ADV
admet-341	167	26	(	(	PUNCT
admet-341	167	27	l	l	NOUN
admet-341	167	28	/	/	SYM
admet-341	167	29	kg	kg	NOUN
admet-341	167	30	)	)	PUNCT
admet-341	167	31	1.7	1.7	NUM
admet-341	167	32	mrt	mrt	PROPN
admet-341	167	33	last	last	ADJ
admet-341	167	34	(	(	PUNCT
admet-341	167	35	h	h	NOUN
admet-341	167	36	)	)	PUNCT
admet-341	167	37	0.4	0.4	NUM
admet-341	167	38	cmax	cmax	NOUN
admet-341	167	39	,	,	PUNCT
admet-341	167	40	po	po	INTJ
admet-341	167	41	(	(	PUNCT
admet-341	167	42	ng	ng	PROPN
admet-341	167	43	/	/	SYM
admet-341	167	44	ml	ml	NOUN
admet-341	167	45	)	)	PUNCT
admet-341	167	46	64	64	NUM
admet-341	167	47	tmax	tmax	NUM
admet-341	167	48	,	,	PUNCT
admet-341	167	49	po	po	INTJ
admet-341	167	50	(	(	PUNCT
admet-341	167	51	h	h	NOUN
admet-341	167	52	)	)	PUNCT
admet-341	167	53	0.25	0.25	NUM
admet-341	167	54	auc0	auc0	NOUN
admet-341	167	55	-	-	PUNCT
admet-341	167	56	24h	24h	PROPN
admet-341	167	57	(	(	PUNCT
admet-341	167	58	ng	ng	PROPN
admet-341	167	59	h	h	PROPN
admet-341	167	60	/ml	/ml	PUNCT
admet-341	167	61	)	)	PUNCT
admet-341	167	62	,	,	PUNCT
admet-341	167	63	iv	iv	X
admet-341	167	64	/	/	SYM
admet-341	167	65	po	po	NOUN
admet-341	167	66	431	431	NUM
admet-341	167	67	25	25	NUM
admet-341	167	68	bioavailability	bioavailability	NOUN
admet-341	167	69	(	(	PUNCT
admet-341	167	70	%	%	NOUN
admet-341	167	71	f	f	X
admet-341	167	72	)	)	PUNCT
admet-341	167	73	2	2	NUM
admet-341	167	74	1	1	NUM
admet-341	167	75	10	10	NUM
admet-341	167	76	100	100	NUM
admet-341	167	77	1.000	1.000	NUM
admet-341	167	78	10.000	10.000	NUM
admet-341	167	79	0	0	NUM
admet-341	167	80	2	2	NUM
admet-341	167	81	4	4	NUM
admet-341	167	82	6	6	NUM
admet-341	167	83	8	8	NUM
admet-341	167	84	10	10	NUM
admet-341	167	85	12	12	NUM
admet-341	167	86	p	p	NOUN
admet-341	167	87	la	la	PROPN
admet-341	167	88	sm	sm	PROPN
admet-341	167	89	a	a	DET
admet-341	167	90	c	c	NOUN
admet-341	167	91	o	o	X
admet-341	167	92	cn	cn	PROPN
admet-341	167	93	e	e	PROPN
admet-341	167	94	tr	tr	VERB
admet-341	167	95	at	at	ADP
admet-341	167	96	io	io	X
admet-341	167	97	n	n	X
admet-341	167	98	(	(	PUNCT
admet-341	167	99	n	n	CCONJ
admet-341	167	100	g/	g/	NOUN
admet-341	167	101	m	m	NOUN
admet-341	167	102	l	l	NOUN
admet-341	167	103	)	)	PUNCT
admet-341	167	104	time	time	NOUN
admet-341	167	105	(	(	PUNCT
admet-341	167	106	h	h	NOUN
admet-341	167	107	)	)	PUNCT
admet-341	167	108	iv	iv	NUM
admet-341	167	109	po	po	PROPN
admet-341	167	110	srinivas	srinivas	PROPN
admet-341	167	111	maddi	maddi	PROPN
admet-341	167	112	et	et	PROPN
admet-341	167	113	al	al	PROPN
admet-341	167	114	.	.	PROPN
admet-341	167	115	admet	admet	PROPN
admet-341	167	116	&	&	CCONJ
admet-341	167	117	dmpk	dmpk	PROPN
admet-341	167	118	4(4	4(4	NUM
admet-341	167	119	)	)	PUNCT
admet-341	167	120	(	(	PUNCT
admet-341	167	121	2016	2016	NUM
admet-341	167	122	)	)	PUNCT
admet-341	167	123	314	314	NUM
admet-341	167	124	-	-	SYM
admet-341	167	125	326	326	NUM
admet-341	167	126	322	322	NUM
admet-341	167	127	table	table	NOUN
admet-341	167	128	4	4	NUM
admet-341	167	129	.	.	PUNCT
admet-341	167	130	pharmacokinetic	pharmacokinetic	ADJ
admet-341	167	131	parameters	parameter	NOUN
admet-341	167	132	of	of	ADP
admet-341	167	133	gbo-006	gbo-006	NOUN
admet-341	167	134	following	follow	VERB
admet-341	167	135	intraperitoneal	intraperitoneal	ADJ
admet-341	167	136	administration	administration	NOUN
admet-341	167	137	in	in	ADP
admet-341	167	138	swiss	swiss	ADJ
admet-341	167	139	albino	albino	NOUN
admet-341	167	140	mouse	mouse	NOUN
admet-341	167	141	at	at	ADP
admet-341	167	142	10	10	NUM
admet-341	167	143	,	,	PUNCT
admet-341	167	144	30	30	NUM
admet-341	167	145	,	,	PUNCT
admet-341	167	146	75	75	NUM
admet-341	167	147	,	,	PUNCT
admet-341	167	148	100	100	NUM
admet-341	167	149	mg	mg	NUM
admet-341	167	150	/	/	SYM
admet-341	167	151	kg	kg	PROPN
admet-341	167	152	dose	dose	NOUN
admet-341	167	153	(	(	PUNCT
admet-341	167	154	mg	mg	PROPN
admet-341	167	155	/	/	SYM
admet-341	167	156	kg	kg	NOUN
admet-341	167	157	)	)	PUNCT
admet-341	167	158	10	10	NUM
admet-341	167	159	30	30	NUM
admet-341	167	160	75	75	NUM
admet-341	167	161	100	100	NUM
admet-341	167	162	formulation	formulation	NOUN
admet-341	167	163	strength	strength	NOUN
admet-341	167	164	(	(	PUNCT
admet-341	167	165	mg	mg	PROPN
admet-341	167	166	/	/	SYM
admet-341	167	167	ml	ml	NOUN
admet-341	167	168	)	)	PUNCT
admet-341	167	169	1	1	NUM
admet-341	167	170	3	3	NUM
admet-341	167	171	7.5	7.5	NUM
admet-341	167	172	10	10	NUM
admet-341	167	173	cmax	cmax	NOUN
admet-341	167	174	(	(	PUNCT
admet-341	167	175	ng	ng	NOUN
admet-341	167	176	/	/	SYM
admet-341	167	177	ml	ml	PROPN
admet-341	167	178	)	)	PUNCT
admet-341	167	179	952	952	NUM
admet-341	167	180	1413	1413	NUM
admet-341	167	181	1354	1354	NUM
admet-341	167	182	1652	1652	NUM
admet-341	167	183	tmax	tmax	ADP
admet-341	167	184	(	(	PUNCT
admet-341	167	185	h	h	NOUN
admet-341	167	186	)	)	PUNCT
admet-341	167	187	0.25	0.25	NUM
admet-341	167	188	4	4	NUM
admet-341	167	189	0.25	0.25	NUM
admet-341	167	190	8	8	NUM
admet-341	167	191	auc0	auc0	NOUN
admet-341	167	192	-	-	PUNCT
admet-341	167	193	24h	24h	NOUN
admet-341	167	194	,	,	PUNCT
admet-341	167	195	(	(	PUNCT
admet-341	167	196	ng	ng	NOUN
admet-341	167	197	/	/	SYM
admet-341	167	198	ml	ml	NOUN
admet-341	167	199	h	h	NOUN
admet-341	167	200	)	)	PUNCT
admet-341	167	201	2451	2451	NUM
admet-341	167	202	13530	13530	NUM
admet-341	167	203	20177	20177	NUM
admet-341	167	204	25592	25592	NUM
admet-341	167	205	auc0-∞(ng	auc0-∞(ng	NOUN
admet-341	167	206	/	/	SYM
admet-341	167	207	ml	ml	NOUN
admet-341	167	208	h	h	NOUN
admet-341	167	209	)	)	PUNCT
admet-341	167	210	2531	2531	NUM
admet-341	167	211	13807	13807	NUM
admet-341	167	212	27067	27067	NUM
admet-341	167	213	33744	33744	NUM
admet-341	167	214	dose	dose	NOUN
admet-341	167	215	normalized	normalize	VERB
admet-341	167	216	auc0-∞	auc0-∞	PUNCT
admet-341	167	217	(	(	PUNCT
admet-341	167	218	ng	ng	PROPN
admet-341	167	219	/ml	/ml	PROPN
admet-341	167	220	h	h	PROPN
admet-341	167	221	)	)	PUNCT
admet-341	167	222	253	253	NUM
admet-341	167	223	460	460	NUM
admet-341	167	224	360	360	NUM
admet-341	167	225	337	337	NUM
admet-341	167	226	figure	figure	NOUN
admet-341	167	227	5	5	NUM
admet-341	167	228	.	.	PUNCT
admet-341	168	1	mean	mean	VERB
admet-341	168	2	plasma	plasma	NOUN
admet-341	168	3	concentration	concentration	NOUN
admet-341	168	4	vs.	vs.	ADP
admet-341	168	5	time	time	NOUN
admet-341	168	6	following	follow	VERB
admet-341	168	7	intraperitoneal	intraperitoneal	ADJ
admet-341	168	8	administration	administration	NOUN
admet-341	168	9	of	of	ADP
admet-341	168	10	gbo-006	gbo-006	NOUN
admet-341	168	11	at	at	ADP
admet-341	168	12	different	different	ADJ
admet-341	168	13	doses	dose	NOUN
admet-341	168	14	in	in	ADP
admet-341	168	15	swiss	swiss	ADJ
admet-341	168	16	albino	albino	NOUN
admet-341	168	17	mice	mouse	NOUN
admet-341	168	18	.	.	PUNCT
admet-341	169	1	pharmacokinetics	pharmacokinetic	NOUN
admet-341	169	2	in	in	ADP
admet-341	169	3	dogs	dog	NOUN
admet-341	169	4	a	a	DET
admet-341	169	5	plasma	plasma	NOUN
admet-341	169	6	concentration	concentration	NOUN
admet-341	169	7	and	and	CCONJ
admet-341	169	8	time	time	NOUN
admet-341	169	9	profile	profile	NOUN
admet-341	169	10	of	of	ADP
admet-341	169	11	gbo-006	gbo-006	NOUN
admet-341	169	12	obtained	obtain	VERB
admet-341	169	13	in	in	ADP
admet-341	169	14	dog	dog	NOUN
admet-341	169	15	is	be	AUX
admet-341	169	16	shown	show	VERB
admet-341	169	17	in	in	ADP
admet-341	169	18	figure	figure	NOUN
admet-341	169	19	6	6	NUM
admet-341	169	20	and	and	CCONJ
admet-341	169	21	corresponding	corresponding	ADJ
admet-341	169	22	pharmacokinetic	pharmacokinetic	ADJ
admet-341	169	23	parameters	parameter	NOUN
admet-341	169	24	are	be	AUX
admet-341	169	25	shown	show	VERB
admet-341	169	26	in	in	ADP
admet-341	169	27	table	table	NOUN
admet-341	169	28	5	5	NUM
admet-341	169	29	.	.	PUNCT
admet-341	169	30	similar	similar	ADJ
admet-341	169	31	to	to	ADP
admet-341	169	32	results	result	NOUN
admet-341	169	33	in	in	ADP
admet-341	169	34	mice	mouse	NOUN
admet-341	169	35	,	,	PUNCT
admet-341	169	36	gbo-006	gbo-006	NOUN
admet-341	169	37	showed	show	VERB
admet-341	169	38	high	high	ADJ
admet-341	169	39	clearance	clearance	NOUN
admet-341	169	40	(	(	PUNCT
admet-341	169	41	47	47	NUM
admet-341	169	42	ml	ml	NOUN
admet-341	169	43	/	/	SYM
admet-341	169	44	min	min	NOUN
admet-341	169	45	/	/	SYM
admet-341	169	46	kg	kg	PROPN
admet-341	169	47	,	,	PUNCT
admet-341	169	48	more	more	ADJ
admet-341	169	49	than	than	ADP
admet-341	169	50	dog	dog	NOUN
admet-341	169	51	hepatic	hepatic	ADJ
admet-341	169	52	blood	blood	NOUN
admet-341	169	53	flow	flow	NOUN
admet-341	169	54	)	)	PUNCT
admet-341	169	55	and	and	CCONJ
admet-341	169	56	short	short	ADJ
admet-341	169	57	plasma	plasma	NOUN
admet-341	169	58	elimination	elimination	NOUN
admet-341	169	59	half	half	ADJ
admet-341	169	60	-	-	PUNCT
admet-341	169	61	life	life	NOUN
admet-341	169	62	(	(	PUNCT
admet-341	169	63	0.7	0.7	NUM
admet-341	169	64	h	h	NOUN
admet-341	169	65	)	)	PUNCT
admet-341	169	66	in	in	ADP
admet-341	169	67	dogs	dog	NOUN
admet-341	169	68	indicating	indicate	VERB
admet-341	169	69	that	that	SCONJ
admet-341	169	70	the	the	DET
admet-341	169	71	compound	compound	NOUN
admet-341	169	72	is	be	AUX
admet-341	169	73	rapidly	rapidly	ADV
admet-341	169	74	eliminated	eliminate	VERB
admet-341	169	75	from	from	ADP
admet-341	169	76	the	the	DET
admet-341	169	77	body	body	NOUN
admet-341	169	78	.	.	PUNCT
admet-341	170	1	the	the	DET
admet-341	170	2	volume	volume	NOUN
admet-341	170	3	of	of	ADP
admet-341	170	4	distribution	distribution	NOUN
admet-341	170	5	of	of	ADP
admet-341	170	6	2.4	2.4	NUM
admet-341	170	7	l	l	NOUN
admet-341	170	8	/	/	SYM
admet-341	170	9	kg	kg	PROPN
admet-341	170	10	provides	provide	VERB
admet-341	170	11	significant	significant	ADJ
admet-341	170	12	distribution	distribution	NOUN
admet-341	170	13	into	into	ADP
admet-341	170	14	extra	extra	ADJ
admet-341	170	15	vascular	vascular	ADJ
admet-341	170	16	space	space	NOUN
admet-341	170	17	.	.	PUNCT
admet-341	171	1	poor	poor	ADJ
admet-341	171	2	bioavailability	bioavailability	NOUN
admet-341	171	3	(	(	PUNCT
admet-341	171	4	6	6	NUM
admet-341	171	5	%	%	NOUN
admet-341	171	6	)	)	PUNCT
admet-341	171	7	after	after	SCONJ
admet-341	171	8	po	po	NOUN
admet-341	171	9	dosing	dosing	NOUN
admet-341	171	10	showed	show	VERB
admet-341	171	11	that	that	SCONJ
admet-341	171	12	the	the	DET
admet-341	171	13	compound	compound	NOUN
admet-341	171	14	did	do	AUX
admet-341	171	15	not	not	PART
admet-341	171	16	show	show	VERB
admet-341	171	17	any	any	DET
admet-341	171	18	absorption	absorption	NOUN
admet-341	171	19	through	through	ADP
admet-341	171	20	gastrointestinal	gastrointestinal	ADJ
admet-341	171	21	tract	tract	NOUN
admet-341	171	22	.	.	PUNCT
admet-341	172	1	10	10	NUM
admet-341	172	2	100	100	NUM
admet-341	172	3	1000	1000	NUM
admet-341	172	4	10000	10000	NUM
admet-341	172	5	0	0	NUM
admet-341	172	6	4	4	NUM
admet-341	172	7	8	8	NUM
admet-341	172	8	12	12	NUM
admet-341	172	9	16	16	NUM
admet-341	172	10	20	20	NUM
admet-341	172	11	24	24	NUM
admet-341	172	12	p	p	NOUN
admet-341	172	13	la	la	PROPN
admet-341	172	14	sm	sm	PROPN
admet-341	172	15	a	a	DET
admet-341	172	16	co	co	X
admet-341	172	17	n	n	PROPN
admet-341	172	18	ce	ce	PROPN
admet-341	172	19	n	n	CCONJ
admet-341	172	20	tr	tr	VERB
admet-341	172	21	at	at	ADP
admet-341	172	22	io	io	X
admet-341	172	23	n	n	X
admet-341	172	24	(	(	PUNCT
admet-341	172	25	n	n	CCONJ
admet-341	172	26	g/	g/	NOUN
admet-341	172	27	m	m	NOUN
admet-341	172	28	l	l	NOUN
admet-341	172	29	)	)	PUNCT
admet-341	172	30	time	time	NOUN
admet-341	172	31	(	(	PUNCT
admet-341	172	32	h	h	NOUN
admet-341	172	33	)	)	PUNCT
admet-341	172	34	100	100	NUM
admet-341	172	35	mg	mg	NUM
admet-341	172	36	/	/	SYM
admet-341	172	37	kg	kg	PROPN
admet-341	172	38	10	10	NUM
admet-341	172	39	mg	mg	PROPN
admet-341	172	40	/	/	SYM
admet-341	172	41	kg	kg	PROPN
admet-341	172	42	30	30	NUM
admet-341	172	43	mg	mg	PROPN
admet-341	172	44	/	/	SYM
admet-341	172	45	kg	kg	NOUN
admet-341	172	46	75mg	75mg	NOUN
admet-341	172	47	/	/	SYM
admet-341	172	48	kg	kg	PROPN
admet-341	172	49	admet	admet	PROPN
admet-341	172	50	&	&	CCONJ
admet-341	172	51	dmpk	dmpk	PROPN
admet-341	172	52	4(4	4(4	NUM
admet-341	172	53	)	)	PUNCT
admet-341	172	54	(	(	PUNCT
admet-341	172	55	2016	2016	NUM
admet-341	172	56	)	)	PUNCT
admet-341	172	57	314	314	NUM
admet-341	172	58	-	-	SYM
admet-341	172	59	326	326	NUM
admet-341	172	60	pharmacokinetics	pharmacokinetic	NOUN
admet-341	172	61	and	and	CCONJ
admet-341	172	62	efficacy	efficacy	NOUN
admet-341	172	63	of	of	ADP
admet-341	172	64	plk2	plk2	PROPN
admet-341	172	65	inhibitor	inhibitor	NOUN
admet-341	172	66	doi	doi	PROPN
admet-341	172	67	:	:	PUNCT
admet-341	172	68	10.5599	10.5599	NUM
admet-341	172	69	/	/	SYM
admet-341	172	70	admet.4.4.341	admet.4.4.341	NOUN
admet-341	172	71	323	323	NUM
admet-341	172	72	figure	figure	NOUN
admet-341	172	73	6	6	NUM
admet-341	172	74	.	.	PUNCT
admet-341	173	1	mean	mean	VERB
admet-341	173	2	plasma	plasma	NOUN
admet-341	173	3	concentration	concentration	NOUN
admet-341	173	4	vs.	vs.	ADP
admet-341	173	5	time	time	NOUN
admet-341	173	6	following	follow	VERB
admet-341	173	7	intravenous	intravenous	ADJ
admet-341	173	8	and	and	CCONJ
admet-341	173	9	oral	oral	ADJ
admet-341	173	10	administration	administration	NOUN
admet-341	173	11	of	of	ADP
admet-341	173	12	gbo-006	gbo-006	NOUN
admet-341	173	13	in	in	ADP
admet-341	173	14	male	male	ADJ
admet-341	173	15	beagle	beagle	NOUN
admet-341	173	16	dog	dog	NOUN
admet-341	173	17	.	.	PUNCT
admet-341	174	1	each	each	DET
admet-341	174	2	point	point	NOUN
admet-341	174	3	(	(	PUNCT
admet-341	174	4	n=3	n=3	NOUN
admet-341	174	5	)	)	PUNCT
admet-341	174	6	represents	represent	VERB
admet-341	174	7	the	the	DET
admet-341	174	8	mean±sd	mean±sd	PROPN
admet-341	174	9	.	.	PUNCT
admet-341	174	10	table	table	NOUN
admet-341	174	11	5	5	NUM
admet-341	174	12	.	.	PUNCT
admet-341	174	13	pharmacokinetic	pharmacokinetic	ADJ
admet-341	174	14	parameters	parameter	NOUN
admet-341	174	15	of	of	ADP
admet-341	174	16	gbo-006	gbo-006	NOUN
admet-341	174	17	following	follow	VERB
admet-341	174	18	its	its	PRON
admet-341	174	19	intravenous	intravenous	ADJ
admet-341	174	20	and	and	CCONJ
admet-341	174	21	oral	oral	ADJ
admet-341	174	22	route	route	NOUN
admet-341	174	23	administration	administration	NOUN
admet-341	174	24	in	in	ADP
admet-341	174	25	beagle	beagle	NOUN
admet-341	174	26	dog	dog	NOUN
admet-341	174	27	.	.	PUNCT
admet-341	175	1	data	datum	NOUN
admet-341	175	2	are	be	AUX
admet-341	175	3	expressed	express	VERB
admet-341	175	4	as	as	ADP
admet-341	175	5	mean	mean	NOUN
admet-341	175	6	±	±	NUM
admet-341	175	7	sd	sd	NOUN
admet-341	175	8	in	in	ADP
admet-341	175	9	three	three	NUM
admet-341	175	10	dogs	dog	NOUN
admet-341	175	11	.	.	PUNCT
admet-341	176	1	iv	iv	NUM
admet-341	176	2	po	po	PROPN
admet-341	176	3	dose	dose	NOUN
admet-341	176	4	(	(	PUNCT
admet-341	176	5	mg	mg	PROPN
admet-341	176	6	/	/	SYM
admet-341	176	7	kg	kg	NOUN
admet-341	176	8	)	)	PUNCT
admet-341	176	9	1	1	NUM
admet-341	176	10	5	5	NUM
admet-341	176	11	cl	cl	NOUN
admet-341	176	12	(	(	PUNCT
admet-341	176	13	ml	ml	NOUN
admet-341	176	14	/	/	SYM
admet-341	176	15	min	min	NOUN
admet-341	176	16	/	/	SYM
admet-341	176	17	kg	kg	NOUN
admet-341	176	18	)	)	PUNCT
admet-341	176	19	47	47	NUM
admet-341	176	20	thalf	thalf	NOUN
admet-341	176	21	(	(	PUNCT
admet-341	176	22	h	h	NOUN
admet-341	176	23	)	)	PUNCT
admet-341	176	24	0.7	0.7	NUM
admet-341	176	25	vdss	vdss	ADV
admet-341	176	26	(	(	PUNCT
admet-341	176	27	l	l	NOUN
admet-341	176	28	/	/	SYM
admet-341	176	29	kg	kg	NOUN
admet-341	176	30	)	)	PUNCT
admet-341	176	31	2.4	2.4	NUM
admet-341	176	32	mrt	mrt	NOUN
admet-341	176	33	last	last	ADJ
admet-341	176	34	(	(	PUNCT
admet-341	176	35	h	h	NOUN
admet-341	176	36	)	)	PUNCT
admet-341	176	37	0.8	0.8	NUM
admet-341	176	38	cmax	cmax	NOUN
admet-341	176	39	,	,	PUNCT
admet-341	176	40	po	po	INTJ
admet-341	176	41	(	(	PUNCT
admet-341	176	42	ng	ng	PROPN
admet-341	176	43	/	/	SYM
admet-341	176	44	ml	ml	NOUN
admet-341	176	45	)	)	PUNCT
admet-341	176	46	70	70	NUM
admet-341	176	47	tmax	tmax	PROPN
admet-341	176	48	,	,	PUNCT
admet-341	176	49	po	po	INTJ
admet-341	176	50	(	(	PUNCT
admet-341	176	51	h	h	NOUN
admet-341	176	52	)	)	PUNCT
admet-341	176	53	0.8	0.8	NUM
admet-341	176	54	auc0	auc0	NOUN
admet-341	176	55	-	-	PUNCT
admet-341	176	56	24h	24h	PROPN
admet-341	176	57	(	(	PUNCT
admet-341	176	58	ng	ng	PROPN
admet-341	176	59	h	h	PROPN
admet-341	176	60	/ml	/ml	PUNCT
admet-341	176	61	)	)	PUNCT
admet-341	176	62	,	,	PUNCT
admet-341	176	63	440	440	NUM
admet-341	176	64	160	160	NUM
admet-341	176	65	bioavailability	bioavailability	NOUN
admet-341	176	66	(	(	PUNCT
admet-341	176	67	%	%	NOUN
admet-341	176	68	f	f	X
admet-341	176	69	)	)	PUNCT
admet-341	176	70	6	6	NUM
admet-341	176	71	xenograft	xenograft	NOUN
admet-341	176	72	model	model	NOUN
admet-341	176	73	gbo-006	gbo-006	PROPN
admet-341	176	74	reduced	reduce	VERB
admet-341	176	75	tumor	tumor	NOUN
admet-341	176	76	volume	volume	NOUN
admet-341	176	77	by	by	ADP
admet-341	176	78	52	52	NUM
admet-341	176	79	and	and	CCONJ
admet-341	176	80	58	58	NUM
admet-341	176	81	%	%	NOUN
admet-341	176	82	at	at	ADP
admet-341	176	83	doses	dose	NOUN
admet-341	176	84	of	of	ADP
admet-341	176	85	30	30	NUM
admet-341	176	86	and	and	CCONJ
admet-341	176	87	75	75	NUM
admet-341	176	88	mg	mg	NUM
admet-341	176	89	/	/	SYM
admet-341	176	90	kg	kg	NOUN
admet-341	176	91	respectively	respectively	ADV
admet-341	176	92	(	(	PUNCT
admet-341	176	93	figure	figure	NOUN
admet-341	176	94	7	7	NUM
admet-341	176	95	)	)	PUNCT
admet-341	176	96	.	.	PUNCT
admet-341	177	1	the	the	DET
admet-341	177	2	tumor	tumor	NOUN
admet-341	177	3	growth	growth	NOUN
admet-341	177	4	inhibition	inhibition	NOUN
admet-341	177	5	at	at	ADP
admet-341	177	6	30	30	NUM
admet-341	177	7	mg	mg	NOUN
admet-341	177	8	/	/	SYM
admet-341	177	9	kg	kg	PROPN
admet-341	177	10	and	and	CCONJ
admet-341	177	11	75	75	NUM
admet-341	177	12	mg	mg	NUM
admet-341	177	13	/	/	SYM
admet-341	177	14	kg	kg	PROPN
admet-341	177	15	dose	dose	NOUN
admet-341	177	16	was	be	AUX
admet-341	177	17	almost	almost	ADV
admet-341	177	18	similar	similar	ADJ
admet-341	177	19	.	.	PUNCT
admet-341	178	1	the	the	DET
admet-341	178	2	lack	lack	NOUN
admet-341	178	3	of	of	ADP
admet-341	178	4	dose	dose	PROPN
admet-341	178	5	dependent	dependent	ADJ
admet-341	178	6	efficacy	efficacy	NOUN
admet-341	178	7	was	be	AUX
admet-341	178	8	not	not	PART
admet-341	178	9	known	know	VERB
admet-341	178	10	at	at	ADP
admet-341	178	11	this	this	DET
admet-341	178	12	movement	movement	NOUN
admet-341	178	13	.	.	PUNCT
admet-341	179	1	no	no	DET
admet-341	179	2	statistically	statistically	ADV
admet-341	179	3	significant	significant	ADJ
admet-341	179	4	weight	weight	NOUN
admet-341	179	5	loss	loss	NOUN
admet-341	179	6	was	be	AUX
admet-341	179	7	found	find	VERB
admet-341	179	8	upon	upon	SCONJ
admet-341	179	9	completion	completion	NOUN
admet-341	179	10	of	of	ADP
admet-341	179	11	the	the	DET
admet-341	179	12	experiment	experiment	NOUN
admet-341	179	13	in	in	ADP
admet-341	179	14	the	the	DET
admet-341	179	15	treated	treat	VERB
admet-341	179	16	groups	group	NOUN
admet-341	179	17	compared	compare	VERB
admet-341	179	18	to	to	ADP
admet-341	179	19	the	the	DET
admet-341	179	20	vehicle	vehicle	NOUN
admet-341	179	21	group	group	NOUN
admet-341	179	22	.	.	PUNCT
admet-341	180	1	there	there	PRON
admet-341	180	2	were	be	VERB
admet-341	180	3	no	no	DET
admet-341	180	4	abnormalities	abnormality	NOUN
admet-341	180	5	found	find	VERB
admet-341	180	6	in	in	ADP
admet-341	180	7	liver	liver	NOUN
admet-341	180	8	,	,	PUNCT
admet-341	180	9	heart	heart	NOUN
admet-341	180	10	,	,	PUNCT
admet-341	180	11	lungs	lung	NOUN
admet-341	180	12	and	and	CCONJ
admet-341	180	13	kidneys	kidney	NOUN
admet-341	180	14	suggesting	suggest	VERB
admet-341	180	15	that	that	SCONJ
admet-341	180	16	the	the	DET
admet-341	180	17	compound	compound	NOUN
admet-341	180	18	was	be	AUX
admet-341	180	19	well	well	ADV
admet-341	180	20	tolerated	tolerate	VERB
admet-341	180	21	up	up	ADP
admet-341	180	22	to	to	PART
admet-341	180	23	75	75	NUM
admet-341	180	24	mg	mg	PROPN
admet-341	180	25	/	/	SYM
admet-341	180	26	kg	kg	PROPN
admet-341	180	27	.	.	NOUN
admet-341	181	1	1	1	NUM
admet-341	181	2	10	10	NUM
admet-341	181	3	100	100	NUM
admet-341	181	4	1000	1000	NUM
admet-341	181	5	0	0	NUM
admet-341	181	6	4	4	NUM
admet-341	181	7	8	8	NUM
admet-341	181	8	12	12	NUM
admet-341	181	9	p	p	PRON
admet-341	181	10	ls	ls	PROPN
admet-341	181	11	am	be	AUX
admet-341	181	12	a	a	DET
admet-341	181	13	co	co	X
admet-341	181	14	n	n	X
admet-341	181	15	ce	ce	PROPN
admet-341	181	16	n	n	CCONJ
admet-341	181	17	tr	tr	VERB
admet-341	181	18	at	at	ADP
admet-341	181	19	io	io	X
admet-341	181	20	n	n	CCONJ
admet-341	181	21	(	(	PUNCT
admet-341	181	22	n	n	CCONJ
admet-341	181	23	g/	g/	NOUN
admet-341	181	24	m	m	NOUN
admet-341	181	25	l	l	NOUN
admet-341	181	26	)	)	PUNCT
admet-341	181	27	time	time	NOUN
admet-341	181	28	(	(	PUNCT
admet-341	181	29	h	h	NOUN
admet-341	181	30	)	)	PUNCT
admet-341	181	31	iv	iv	NUM
admet-341	182	1	po	po	PROPN
admet-341	182	2	srinivas	srinivas	PROPN
admet-341	182	3	maddi	maddi	PROPN
admet-341	182	4	et	et	PROPN
admet-341	182	5	al	al	PROPN
admet-341	182	6	.	.	PROPN
admet-341	182	7	admet	admet	PROPN
admet-341	182	8	&	&	CCONJ
admet-341	182	9	dmpk	dmpk	PROPN
admet-341	182	10	4(4	4(4	NUM
admet-341	182	11	)	)	PUNCT
admet-341	182	12	(	(	PUNCT
admet-341	182	13	2016	2016	NUM
admet-341	182	14	)	)	PUNCT
admet-341	182	15	314	314	NUM
admet-341	182	16	-	-	SYM
admet-341	182	17	326	326	NUM
admet-341	182	18	324	324	NUM
admet-341	182	19	figure	figure	NOUN
admet-341	182	20	7	7	NUM
admet-341	182	21	.	.	PUNCT
admet-341	182	22	scid	scid	NOUN
admet-341	182	23	mice	mouse	NOUN
admet-341	182	24	bearing	bear	VERB
admet-341	182	25	established	establish	VERB
admet-341	182	26	tumors	tumor	NOUN
admet-341	182	27	(	(	PUNCT
admet-341	182	28	100	100	NUM
admet-341	182	29	mm	mm	NOUN
admet-341	182	30	3	3	NUM
admet-341	182	31	)	)	PUNCT
admet-341	182	32	from	from	ADP
admet-341	182	33	mda	mda	PROPN
admet-341	182	34	-	-	PUNCT
admet-341	182	35	mb-231	mb-231	PROPN
admet-341	182	36	cells	cell	NOUN
admet-341	182	37	were	be	AUX
admet-341	182	38	treated	treat	VERB
admet-341	182	39	with	with	ADP
admet-341	182	40	gbo006	gbo006	PROPN
admet-341	182	41	at	at	ADP
admet-341	182	42	30	30	NUM
admet-341	182	43	mg	mg	PROPN
admet-341	182	44	/	/	SYM
admet-341	182	45	kg	kg	PROPN
admet-341	182	46	(	(	PUNCT
admet-341	182	47	triangle	triangle	NOUN
admet-341	182	48	)	)	PUNCT
admet-341	182	49	,	,	PUNCT
admet-341	182	50	75	75	NUM
admet-341	182	51	mg	mg	NUM
admet-341	182	52	/	/	SYM
admet-341	182	53	kg	kg	PROPN
admet-341	182	54	(	(	PUNCT
admet-341	182	55	square	square	NOUN
admet-341	182	56	)	)	PUNCT
admet-341	182	57	,	,	PUNCT
admet-341	182	58	or	or	CCONJ
admet-341	182	59	vehicle	vehicle	NOUN
admet-341	182	60	(	(	PUNCT
admet-341	182	61	circle	circle	PROPN
admet-341	182	62	)	)	PUNCT
admet-341	182	63	for	for	ADP
admet-341	182	64	approximately	approximately	ADV
admet-341	182	65	24	24	NUM
admet-341	182	66	days	day	NOUN
admet-341	182	67	.	.	PUNCT
admet-341	183	1	serial	serial	ADJ
admet-341	183	2	tumor	tumor	NOUN
admet-341	183	3	volumes	volume	NOUN
admet-341	183	4	(	(	PUNCT
admet-341	183	5	mm	mm	NOUN
admet-341	183	6	3	3	NUM
admet-341	183	7	)	)	PUNCT
admet-341	183	8	were	be	AUX
admet-341	183	9	measured	measure	VERB
admet-341	183	10	at	at	ADP
admet-341	183	11	the	the	DET
admet-341	183	12	indicated	indicate	VERB
admet-341	183	13	days	day	NOUN
admet-341	183	14	.	.	PUNCT
admet-341	184	1	each	each	DET
admet-341	184	2	data	datum	NOUN
admet-341	184	3	point	point	NOUN
admet-341	184	4	represents	represent	VERB
admet-341	184	5	the	the	DET
admet-341	184	6	mean	mean	ADJ
admet-341	184	7	tumor	tumor	NOUN
admet-341	184	8	volume	volume	NOUN
admet-341	184	9	of	of	ADP
admet-341	184	10	8	8	NUM
admet-341	184	11	tumors	tumor	NOUN
admet-341	184	12	.	.	PUNCT
admet-341	185	1	discussion	discussion	NOUN
admet-341	185	2	gbo-006	gbo-006	NOUN
admet-341	185	3	is	be	AUX
admet-341	185	4	a	a	DET
admet-341	185	5	small	small	ADJ
admet-341	185	6	plk2	plk2	NOUN
admet-341	185	7	selective	selective	ADJ
admet-341	185	8	kinase	kinase	PROPN
admet-341	185	9	inhibitor	inhibitor	NOUN
admet-341	185	10	which	which	PRON
admet-341	185	11	showed	show	VERB
admet-341	185	12	cytotoxicity	cytotoxicity	NOUN
admet-341	185	13	against	against	ADP
admet-341	185	14	the	the	DET
admet-341	185	15	entire	entire	ADJ
admet-341	185	16	panel	panel	NOUN
admet-341	185	17	of	of	ADP
admet-341	185	18	16	16	NUM
admet-341	185	19	tumor	tumor	NOUN
admet-341	185	20	cell	cell	NOUN
admet-341	185	21	lines	line	NOUN
admet-341	185	22	,	,	PUNCT
admet-341	185	23	with	with	ADP
admet-341	185	24	little	little	ADJ
admet-341	185	25	or	or	CCONJ
admet-341	185	26	no	no	PRON
admet-341	185	27	cytotoxicity	cytotoxicity	NOUN
admet-341	185	28	towards	towards	ADP
admet-341	185	29	normal	normal	ADJ
admet-341	185	30	cells	cell	NOUN
admet-341	185	31	.	.	PUNCT
admet-341	186	1	kinase	kinase	NOUN
admet-341	186	2	inhibition	inhibition	VERB
admet-341	186	3	assays	assay	NOUN
admet-341	186	4	against	against	ADP
admet-341	186	5	a	a	DET
admet-341	186	6	panel	panel	NOUN
admet-341	186	7	of	of	ADP
admet-341	186	8	285	285	NUM
admet-341	186	9	kinases	kinase	NOUN
admet-341	186	10	revealed	reveal	VERB
admet-341	186	11	that	that	SCONJ
admet-341	186	12	this	this	DET
admet-341	186	13	compound	compound	NOUN
admet-341	186	14	had	have	VERB
admet-341	186	15	a	a	DET
admet-341	186	16	remarkable	remarkable	ADJ
admet-341	186	17	specificity	specificity	NOUN
admet-341	186	18	towards	towards	ADP
admet-341	186	19	plk2	plk2	PROPN
admet-341	186	20	/	/	SYM
admet-341	186	21	snk	snk	PROPN
admet-341	186	22	,	,	PUNCT
admet-341	186	23	a	a	DET
admet-341	186	24	kinase	kinase	NOUN
admet-341	186	25	involved	involve	VERB
admet-341	186	26	in	in	ADP
admet-341	186	27	centrosome	centrosome	NOUN
admet-341	186	28	duplication	duplication	NOUN
admet-341	186	29	and	and	CCONJ
admet-341	186	30	mitotic	mitotic	ADJ
admet-341	186	31	progression	progression	NOUN
admet-341	186	32	[	[	X
admet-341	186	33	11	11	NUM
admet-341	186	34	-	-	SYM
admet-341	186	35	13	13	NUM
admet-341	186	36	]	]	PUNCT
admet-341	186	37	.	.	PUNCT
admet-341	187	1	most	most	ADV
admet-341	187	2	importantly	importantly	ADV
admet-341	187	3	,	,	PUNCT
admet-341	187	4	plk2	plk2	PROPN
admet-341	187	5	has	have	AUX
admet-341	187	6	recently	recently	ADV
admet-341	187	7	been	be	AUX
admet-341	187	8	implicated	implicate	VERB
admet-341	187	9	as	as	ADP
admet-341	187	10	one	one	NUM
admet-341	187	11	of	of	ADP
admet-341	187	12	the	the	DET
admet-341	187	13	kinases	kinase	NOUN
admet-341	187	14	that	that	PRON
admet-341	187	15	links	link	VERB
admet-341	187	16	cellular	cellular	ADJ
admet-341	187	17	metabolism	metabolism	NOUN
admet-341	187	18	to	to	ADP
admet-341	187	19	cell	cell	NOUN
admet-341	187	20	cycle	cycle	NOUN
admet-341	187	21	.	.	PUNCT
admet-341	188	1	mitochondrial	mitochondrial	ADJ
admet-341	188	2	dysfunction	dysfunction	NOUN
admet-341	188	3	with	with	ADP
admet-341	188	4	increased	increase	VERB
admet-341	188	5	dependence	dependence	NOUN
admet-341	188	6	on	on	ADP
admet-341	188	7	glycolysis	glycolysis	NOUN
admet-341	188	8	is	be	AUX
admet-341	188	9	frequently	frequently	ADV
admet-341	188	10	observed	observe	VERB
admet-341	188	11	in	in	ADP
admet-341	188	12	cancer	cancer	NOUN
admet-341	188	13	cells	cell	NOUN
admet-341	188	14	(	(	PUNCT
admet-341	188	15	known	know	VERB
admet-341	188	16	as	as	ADP
admet-341	188	17	the	the	DET
admet-341	188	18	warburg	warburg	NOUN
admet-341	188	19	effect	effect	NOUN
admet-341	188	20	)	)	PUNCT
admet-341	188	21	and	and	CCONJ
admet-341	188	22	identification	identification	NOUN
admet-341	188	23	of	of	ADP
admet-341	188	24	pathways	pathway	NOUN
admet-341	188	25	that	that	PRON
admet-341	188	26	promote	promote	VERB
admet-341	188	27	cell	cell	NOUN
admet-341	188	28	survival	survival	NOUN
admet-341	188	29	under	under	ADP
admet-341	188	30	conditions	condition	NOUN
admet-341	188	31	of	of	ADP
admet-341	188	32	mitochondrial	mitochondrial	ADJ
admet-341	188	33	dysfunction	dysfunction	NOUN
admet-341	188	34	has	have	VERB
admet-341	188	35	therapeutic	therapeutic	ADJ
admet-341	188	36	implications	implication	NOUN
admet-341	189	1	[	[	X
admet-341	189	2	14	14	NUM
admet-341	189	3	]	]	PUNCT
admet-341	189	4	.	.	PUNCT
admet-341	190	1	intraperitoneal	intraperitoneal	ADJ
admet-341	190	2	alternate	alternate	ADJ
admet-341	190	3	day	day	NOUN
admet-341	190	4	dosing	dose	VERB
admet-341	190	5	of	of	ADP
admet-341	190	6	gbo-006	gbo-006	NOUN
admet-341	190	7	using	use	VERB
admet-341	190	8	100	100	NUM
admet-341	190	9	%	%	NOUN
admet-341	190	10	dmso	dmso	NOUN
admet-341	190	11	as	as	SCONJ
admet-341	190	12	formulation	formulation	NOUN
admet-341	190	13	caused	cause	VERB
admet-341	190	14	significant	significant	ADJ
admet-341	190	15	tumor	tumor	NOUN
admet-341	190	16	regression	regression	NOUN
admet-341	190	17	in	in	ADP
admet-341	190	18	xenograft	xenograft	NOUN
admet-341	190	19	models	model	NOUN
admet-341	190	20	,	,	PUNCT
admet-341	190	21	demonstrating	demonstrate	VERB
admet-341	190	22	proof	proof	NOUN
admet-341	190	23	of	of	ADP
admet-341	190	24	concept	concept	NOUN
admet-341	190	25	of	of	ADP
admet-341	190	26	plk2	plk2	NOUN
admet-341	190	27	inhibition	inhibition	NOUN
admet-341	190	28	in	in	ADP
admet-341	190	29	vivo	vivo	NOUN
admet-341	190	30	.	.	PUNCT
admet-341	191	1	these	these	DET
admet-341	191	2	studies	study	NOUN
admet-341	191	3	necessitated	necessitate	VERB
admet-341	191	4	the	the	DET
admet-341	191	5	need	need	NOUN
admet-341	191	6	to	to	PART
admet-341	191	7	develop	develop	VERB
admet-341	191	8	a	a	DET
admet-341	191	9	formulation	formulation	NOUN
admet-341	191	10	for	for	ADP
admet-341	191	11	pharmacokinetic	pharmacokinetic	ADJ
admet-341	191	12	and	and	CCONJ
admet-341	191	13	efficacy	efficacy	NOUN
admet-341	191	14	studies	study	NOUN
admet-341	191	15	.	.	PUNCT
admet-341	192	1	the	the	DET
admet-341	192	2	present	present	ADJ
admet-341	192	3	communication	communication	NOUN
admet-341	192	4	describes	describe	VERB
admet-341	192	5	the	the	DET
admet-341	192	6	development	development	NOUN
admet-341	192	7	of	of	ADP
admet-341	192	8	preclinical	preclinical	ADJ
admet-341	192	9	formulation	formulation	NOUN
admet-341	192	10	to	to	PART
admet-341	192	11	characterize	characterize	VERB
admet-341	192	12	the	the	DET
admet-341	192	13	pharmacokinetic	pharmacokinetic	ADJ
admet-341	192	14	properties	property	NOUN
admet-341	192	15	and	and	CCONJ
admet-341	192	16	efficacy	efficacy	NOUN
admet-341	192	17	of	of	ADP
admet-341	192	18	gbo-006	gbo-006	NOUN
admet-341	192	19	in	in	ADP
admet-341	192	20	xenograft	xenograft	NOUN
admet-341	192	21	models	model	NOUN
admet-341	192	22	to	to	PART
admet-341	192	23	determine	determine	VERB
admet-341	192	24	the	the	DET
admet-341	192	25	degree	degree	NOUN
admet-341	192	26	of	of	ADP
admet-341	192	27	inhibition	inhibition	NOUN
admet-341	192	28	of	of	ADP
admet-341	192	29	plk2	plk2	NOUN
admet-341	192	30	that	that	PRON
admet-341	192	31	is	be	AUX
admet-341	192	32	required	require	VERB
admet-341	192	33	for	for	ADP
admet-341	192	34	inhibition	inhibition	NOUN
admet-341	192	35	of	of	ADP
admet-341	192	36	tumor	tumor	NOUN
admet-341	192	37	growth	growth	NOUN
admet-341	192	38	and	and	CCONJ
admet-341	192	39	assess	assess	VERB
admet-341	192	40	how	how	SCONJ
admet-341	192	41	concentrations	concentration	NOUN
admet-341	192	42	are	be	AUX
admet-341	192	43	related	relate	VERB
admet-341	192	44	to	to	ADP
admet-341	192	45	antitumor	antitumor	NOUN
admet-341	192	46	activity	activity	NOUN
admet-341	192	47	of	of	ADP
admet-341	192	48	the	the	DET
admet-341	192	49	compound	compound	NOUN
admet-341	192	50	and	and	CCONJ
admet-341	192	51	to	to	PART
admet-341	192	52	evaluate	evaluate	VERB
admet-341	192	53	the	the	DET
admet-341	192	54	validity	validity	NOUN
admet-341	192	55	of	of	ADP
admet-341	192	56	using	use	VERB
admet-341	192	57	pbmn	pbmn	NOUN
admet-341	192	58	as	as	ADP
admet-341	192	59	surrogates	surrogate	NOUN
admet-341	192	60	.	.	PUNCT
admet-341	193	1	gbo-006	gbo-006	PROPN
admet-341	193	2	possesses	possesse	NOUN
admet-341	193	3	challenging	challenge	VERB
admet-341	193	4	physicochemical	physicochemical	ADJ
admet-341	193	5	and	and	CCONJ
admet-341	193	6	biopharmaceutical	biopharmaceutical	NOUN
admet-341	193	7	properties	property	NOUN
admet-341	193	8	like	like	ADP
admet-341	193	9	poor	poor	ADJ
admet-341	193	10	solubility	solubility	NOUN
admet-341	193	11	in	in	ADP
admet-341	193	12	aqueous	aqueous	ADJ
admet-341	193	13	media	medium	NOUN
admet-341	193	14	,	,	PUNCT
admet-341	193	15	low	low	ADJ
admet-341	193	16	permeability	permeability	NOUN
admet-341	193	17	and	and	CCONJ
admet-341	193	18	a	a	DET
admet-341	193	19	crystalline	crystalline	ADJ
admet-341	193	20	nature	nature	NOUN
admet-341	193	21	.	.	PUNCT
admet-341	194	1	the	the	DET
admet-341	194	2	poor	poor	ADJ
admet-341	194	3	solubility	solubility	NOUN
admet-341	194	4	of	of	ADP
admet-341	194	5	gbo-006	gbo-006	NOUN
admet-341	194	6	in	in	ADP
admet-341	194	7	non	non	ADJ
admet-341	194	8	-	-	ADJ
admet-341	194	9	aqueous	aqueous	ADJ
admet-341	194	10	media	medium	NOUN
admet-341	194	11	including	include	VERB
admet-341	194	12	lipids	lipid	NOUN
admet-341	194	13	&	&	CCONJ
admet-341	194	14	oils	oil	NOUN
admet-341	194	15	,	,	PUNCT
admet-341	194	16	limited	limit	VERB
admet-341	194	17	any	any	DET
admet-341	194	18	further	further	ADJ
admet-341	194	19	usage	usage	NOUN
admet-341	194	20	of	of	ADP
admet-341	194	21	lipid	lipid	NOUN
admet-341	194	22	-	-	PUNCT
admet-341	194	23	based	base	VERB
admet-341	194	24	technologies	technology	NOUN
admet-341	194	25	.	.	PUNCT
admet-341	195	1	gbo-006	gbo-006	PROPN
admet-341	195	2	was	be	AUX
admet-341	195	3	found	find	VERB
admet-341	195	4	to	to	PART
admet-341	195	5	melt	melt	VERB
admet-341	195	6	with	with	ADP
admet-341	195	7	degradation	degradation	NOUN
admet-341	195	8	at	at	ADP
admet-341	195	9	very	very	ADV
admet-341	195	10	high	high	ADJ
admet-341	195	11	temperatures	temperature	NOUN
admet-341	195	12	(	(	PUNCT
admet-341	195	13	~346	~346	PROPN
admet-341	195	14	°	°	PROPN
admet-341	195	15	c	c	NOUN
admet-341	195	16	)	)	PUNCT
admet-341	195	17	,	,	PUNCT
admet-341	195	18	which	which	PRON
admet-341	195	19	limited	limit	VERB
admet-341	195	20	the	the	DET
admet-341	195	21	usage	usage	NOUN
admet-341	195	22	of	of	ADP
admet-341	195	23	any	any	DET
admet-341	195	24	amorphous	amorphous	ADJ
admet-341	195	25	based	base	VERB
admet-341	195	26	strategies	strategy	NOUN
admet-341	195	27	.	.	PUNCT
admet-341	196	1	in	in	ADP
admet-341	196	2	order	order	NOUN
admet-341	196	3	to	to	PART
admet-341	196	4	understand	understand	VERB
admet-341	196	5	the	the	DET
admet-341	196	6	solubility	solubility	NOUN
admet-341	196	7	,	,	PUNCT
admet-341	196	8	initial	initial	ADJ
admet-341	196	9	screening	screening	NOUN
admet-341	196	10	was	be	AUX
admet-341	196	11	conducted	conduct	VERB
admet-341	196	12	in	in	ADP
admet-341	196	13	different	different	ADJ
admet-341	196	14	concentrations	concentration	NOUN
admet-341	196	15	and	and	CCONJ
admet-341	196	16	combinations	combination	NOUN
admet-341	196	17	of	of	ADP
admet-341	196	18	cosolvents	cosolvent	NOUN
admet-341	196	19	and	and	CCONJ
admet-341	196	20	surfactants	surfactant	NOUN
admet-341	196	21	.	.	PUNCT
admet-341	197	1	among	among	ADP
admet-341	197	2	the	the	DET
admet-341	197	3	various	various	ADJ
admet-341	197	4	combinations	combination	NOUN
admet-341	197	5	and	and	CCONJ
admet-341	197	6	various	various	ADJ
admet-341	197	7	solvent	solvent	NOUN
admet-341	197	8	compositions	composition	NOUN
admet-341	197	9	tried	try	VERB
admet-341	197	10	in	in	ADP
admet-341	197	11	our	our	PRON
admet-341	197	12	laboratory	laboratory	NOUN
admet-341	197	13	,	,	PUNCT
admet-341	197	14	a	a	DET
admet-341	197	15	cosolvent	cosolvent	ADJ
admet-341	197	16	system	system	NOUN
admet-341	197	17	was	be	AUX
admet-341	197	18	chosen	choose	VERB
admet-341	197	19	consisting	consist	VERB
admet-341	197	20	of	of	ADP
admet-341	197	21	dmso	dmso	NOUN
admet-341	197	22	,	,	PUNCT
admet-341	197	23	peg	peg	NOUN
admet-341	197	24	400	400	NUM
admet-341	197	25	,	,	PUNCT
admet-341	197	26	solutol	solutol	ADJ
admet-341	197	27	and	and	CCONJ
admet-341	197	28	100	100	NUM
admet-341	197	29	mm	mm	NOUN
admet-341	197	30	citrate	citrate	NOUN
admet-341	197	31	buffer	buffer	NOUN
admet-341	197	32	at	at	ADP
admet-341	197	33	20:40:10:30	20:40:10:30	NOUN
admet-341	197	34	(	(	PUNCT
admet-341	197	35	v	v	NOUN
admet-341	197	36	/	/	SYM
admet-341	197	37	v	v	NOUN
admet-341	197	38	/	/	SYM
admet-341	197	39	v	v	NOUN
admet-341	197	40	/	/	SYM
admet-341	197	41	v	v	NOUN
admet-341	197	42	)	)	PUNCT
admet-341	197	43	ratios	ratio	NOUN
admet-341	197	44	.	.	PUNCT
admet-341	198	1	this	this	DET
admet-341	198	2	system	system	NOUN
admet-341	198	3	showed	show	VERB
admet-341	198	4	10	10	NUM
admet-341	198	5	mg	mg	NUM
admet-341	198	6	/	/	SYM
admet-341	198	7	ml	ml	NOUN
admet-341	198	8	drug	drug	NOUN
admet-341	198	9	solubility	solubility	NOUN
admet-341	198	10	without	without	ADP
admet-341	198	11	drug	drug	NOUN
admet-341	198	12	precipitation	precipitation	NOUN
admet-341	198	13	up	up	ADP
admet-341	198	14	to	to	ADP
admet-341	198	15	storage	storage	NOUN
admet-341	198	16	of	of	ADP
admet-341	198	17	24	24	NUM
admet-341	198	18	h.	h.	PROPN
admet-341	198	19	thus	thus	ADV
admet-341	198	20	,	,	PUNCT
admet-341	198	21	this	this	DET
admet-341	198	22	formulation	formulation	NOUN
admet-341	198	23	was	be	AUX
admet-341	198	24	selected	select	VERB
admet-341	198	25	for	for	ADP
admet-341	198	26	in	in	ADP
admet-341	198	27	0	0	NUM
admet-341	198	28	50	50	NUM
admet-341	198	29	100	100	NUM
admet-341	198	30	150	150	NUM
admet-341	198	31	200	200	NUM
admet-341	198	32	250	250	NUM
admet-341	198	33	300	300	NUM
admet-341	198	34	350	350	NUM
admet-341	198	35	400	400	NUM
admet-341	198	36	450	450	NUM
admet-341	198	37	0	0	NUM
admet-341	198	38	2	2	NUM
admet-341	198	39	4	4	NUM
admet-341	198	40	6	6	NUM
admet-341	198	41	8	8	NUM
admet-341	198	42	10	10	NUM
admet-341	198	43	12	12	NUM
admet-341	198	44	14	14	NUM
admet-341	198	45	16	16	NUM
admet-341	198	46	18	18	NUM
admet-341	198	47	20	20	NUM
admet-341	198	48	22	22	NUM
admet-341	198	49	24	24	NUM
admet-341	198	50	26	26	NUM
admet-341	198	51	a	a	DET
admet-341	198	52	ve	ve	NOUN
admet-341	198	53	ra	ra	PROPN
admet-341	198	54	ge	ge	PROPN
admet-341	199	1	t	t	PROPN
admet-341	199	2	u	u	PROPN
admet-341	199	3	m	m	NOUN
admet-341	199	4	o	o	NOUN
admet-341	199	5	r	r	NOUN
admet-341	199	6	v	v	NOUN
admet-341	199	7	o	o	X
admet-341	200	1	lu	lu	NOUN
admet-341	200	2	m	m	VERB
admet-341	200	3	e	e	NOUN
admet-341	200	4	(	(	PUNCT
admet-341	200	5	m	m	VERB
admet-341	200	6	m	m	VERB
admet-341	200	7	3	3	NUM
admet-341	200	8	)	)	PUNCT
admet-341	200	9	days	day	NOUN
admet-341	200	10	vehicle	vehicle	NOUN
admet-341	200	11	30	30	NUM
admet-341	200	12	mg	mg	PROPN
admet-341	200	13	/	/	SYM
admet-341	200	14	kg	kg	PROPN
admet-341	200	15	75	75	NUM
admet-341	200	16	mg	mg	PROPN
admet-341	200	17	/	/	SYM
admet-341	200	18	kg	kg	PROPN
admet-341	200	19	admet	admet	PROPN
admet-341	200	20	&	&	CCONJ
admet-341	200	21	dmpk	dmpk	PROPN
admet-341	200	22	4(4	4(4	NUM
admet-341	200	23	)	)	PUNCT
admet-341	200	24	(	(	PUNCT
admet-341	200	25	2016	2016	NUM
admet-341	200	26	)	)	PUNCT
admet-341	200	27	314	314	NUM
admet-341	200	28	-	-	SYM
admet-341	200	29	326	326	NUM
admet-341	200	30	pharmacokinetics	pharmacokinetic	NOUN
admet-341	200	31	and	and	CCONJ
admet-341	200	32	efficacy	efficacy	NOUN
admet-341	200	33	of	of	ADP
admet-341	200	34	plk2	plk2	PROPN
admet-341	200	35	inhibitor	inhibitor	NOUN
admet-341	200	36	doi	doi	PROPN
admet-341	200	37	:	:	PUNCT
admet-341	200	38	10.5599	10.5599	NUM
admet-341	200	39	/	/	SYM
admet-341	200	40	admet.4.4.341	admet.4.4.341	NOUN
admet-341	200	41	325	325	NUM
admet-341	200	42	vivo	vivo	ADJ
admet-341	200	43	pharmacokinetic	pharmacokinetic	NOUN
admet-341	200	44	and	and	CCONJ
admet-341	200	45	efficacy	efficacy	NOUN
admet-341	200	46	evaluations	evaluation	NOUN
admet-341	200	47	.	.	PUNCT
admet-341	201	1	dmso	dmso	NOUN
admet-341	201	2	and	and	CCONJ
admet-341	201	3	peg	peg	NOUN
admet-341	201	4	400	400	NUM
admet-341	201	5	are	be	AUX
admet-341	201	6	the	the	DET
admet-341	201	7	major	major	ADJ
admet-341	201	8	pharmaceutical	pharmaceutical	ADJ
admet-341	201	9	cosolvents	cosolvent	NOUN
admet-341	201	10	with	with	ADP
admet-341	201	11	strong	strong	ADJ
admet-341	201	12	solubilizing	solubilizing	NOUN
admet-341	201	13	properties	property	NOUN
admet-341	201	14	and	and	CCONJ
admet-341	201	15	widely	widely	ADV
admet-341	201	16	used	use	VERB
admet-341	201	17	in	in	ADP
admet-341	201	18	oral	oral	ADJ
admet-341	201	19	and	and	CCONJ
admet-341	201	20	parenteral	parenteral	ADJ
admet-341	201	21	formulations	formulation	NOUN
admet-341	201	22	.	.	PUNCT
admet-341	202	1	dmso	dmso	NOUN
admet-341	202	2	is	be	AUX
admet-341	202	3	a	a	DET
admet-341	202	4	water	water	NOUN
admet-341	202	5	miscible	miscible	ADJ
admet-341	202	6	polar	polar	ADJ
admet-341	202	7	aprotic	aprotic	ADJ
admet-341	202	8	solvent	solvent	NOUN
admet-341	202	9	with	with	ADP
admet-341	202	10	high	high	ADJ
admet-341	202	11	interfacial	interfacial	ADJ
admet-341	202	12	activity	activity	NOUN
admet-341	202	13	as	as	ADP
admet-341	202	14	a	a	DET
admet-341	202	15	drug	drug	NOUN
admet-341	202	16	solubilizer	solubilizer	NOUN
admet-341	202	17	and	and	CCONJ
admet-341	202	18	a	a	DET
admet-341	202	19	penetration	penetration	NOUN
admet-341	202	20	enhancer	enhancer	NOUN
admet-341	202	21	[	[	X
admet-341	202	22	15	15	NUM
admet-341	202	23	]	]	PUNCT
admet-341	202	24	.	.	PUNCT
admet-341	203	1	it	it	PRON
admet-341	203	2	also	also	ADV
admet-341	203	3	belongs	belong	VERB
admet-341	203	4	to	to	ADP
admet-341	203	5	the	the	DET
admet-341	203	6	class	class	NOUN
admet-341	203	7	of	of	ADP
admet-341	203	8	dipolar	dipolar	ADJ
admet-341	203	9	aprotic	aprotic	ADJ
admet-341	203	10	solvents	solvent	NOUN
admet-341	203	11	which	which	PRON
admet-341	203	12	includes	include	VERB
admet-341	203	13	dimethylformamide	dimethylformamide	NOUN
admet-341	203	14	and	and	CCONJ
admet-341	203	15	dimethylacetamide	dimethylacetamide	NOUN
admet-341	203	16	.	.	PUNCT
admet-341	204	1	the	the	DET
admet-341	204	2	cosolvent	cosolvent	ADJ
admet-341	204	3	approach	approach	NOUN
admet-341	204	4	is	be	AUX
admet-341	204	5	based	base	VERB
admet-341	204	6	on	on	ADP
admet-341	204	7	the	the	DET
admet-341	204	8	fact	fact	NOUN
admet-341	204	9	that	that	SCONJ
admet-341	204	10	low	low	ADJ
admet-341	204	11	aqueous	aqueous	ADJ
admet-341	204	12	solubility	solubility	NOUN
admet-341	204	13	of	of	ADP
admet-341	204	14	drugs	drug	NOUN
admet-341	204	15	is	be	AUX
admet-341	204	16	due	due	ADJ
admet-341	204	17	to	to	ADP
admet-341	204	18	great	great	ADJ
admet-341	204	19	difference	difference	NOUN
admet-341	204	20	in	in	ADP
admet-341	204	21	polarity	polarity	NOUN
admet-341	204	22	of	of	ADP
admet-341	204	23	the	the	DET
admet-341	204	24	two	two	NUM
admet-341	204	25	components	component	NOUN
admet-341	204	26	.	.	PUNCT
admet-341	205	1	thus	thus	ADV
admet-341	205	2	when	when	SCONJ
admet-341	205	3	a	a	DET
admet-341	205	4	cosolvent	cosolvent	NOUN
admet-341	205	5	having	have	VERB
admet-341	205	6	a	a	DET
admet-341	205	7	polarity	polarity	NOUN
admet-341	205	8	value	value	NOUN
admet-341	205	9	less	less	ADJ
admet-341	205	10	than	than	ADP
admet-341	205	11	that	that	PRON
admet-341	205	12	of	of	ADP
admet-341	205	13	water	water	NOUN
admet-341	205	14	is	be	AUX
admet-341	205	15	added	add	VERB
admet-341	205	16	,	,	PUNCT
admet-341	205	17	the	the	DET
admet-341	205	18	polarity	polarity	NOUN
admet-341	205	19	difference	difference	NOUN
admet-341	205	20	between	between	ADP
admet-341	205	21	the	the	DET
admet-341	205	22	drug	drug	NOUN
admet-341	205	23	and	and	CCONJ
admet-341	205	24	the	the	DET
admet-341	205	25	water	water	NOUN
admet-341	205	26	-	-	PUNCT
admet-341	205	27	co	co	VERB
admet-341	205	28	solvent	solvent	NOUN
admet-341	205	29	system	system	NOUN
admet-341	205	30	reduces	reduce	VERB
admet-341	205	31	thereby	thereby	ADV
admet-341	205	32	increase	increase	VERB
admet-341	205	33	the	the	DET
admet-341	205	34	solubility	solubility	NOUN
admet-341	205	35	of	of	ADP
admet-341	205	36	drug	drug	NOUN
admet-341	205	37	[	[	X
admet-341	205	38	16	16	NUM
admet-341	205	39	]	]	PUNCT
admet-341	205	40	.	.	PUNCT
admet-341	206	1	gbo-006	gbo-006	PROPN
admet-341	206	2	pharmacokinetic	pharmacokinetic	ADJ
admet-341	206	3	studies	study	NOUN
admet-341	206	4	provided	provide	VERB
admet-341	206	5	an	an	DET
admet-341	206	6	overview	overview	NOUN
admet-341	206	7	of	of	ADP
admet-341	206	8	the	the	DET
admet-341	206	9	absorption	absorption	NOUN
admet-341	206	10	and	and	CCONJ
admet-341	206	11	disposition	disposition	NOUN
admet-341	206	12	behavior	behavior	NOUN
admet-341	206	13	in	in	ADP
admet-341	206	14	animal	animal	NOUN
admet-341	206	15	models	model	NOUN
admet-341	206	16	.	.	PUNCT
admet-341	207	1	gbo-006	gbo-006	PROPN
admet-341	207	2	showed	show	VERB
admet-341	207	3	very	very	ADV
admet-341	207	4	poor	poor	ADJ
admet-341	207	5	oral	oral	ADJ
admet-341	207	6	bioavailability	bioavailability	NOUN
admet-341	207	7	(	(	PUNCT
admet-341	207	8	2	2	NUM
admet-341	207	9	-	-	SYM
admet-341	207	10	6	6	NUM
admet-341	207	11	%	%	NOUN
admet-341	207	12	)	)	PUNCT
admet-341	207	13	across	across	ADP
admet-341	207	14	mice	mouse	NOUN
admet-341	207	15	,	,	PUNCT
admet-341	207	16	rats	rat	NOUN
admet-341	207	17	and	and	CCONJ
admet-341	207	18	dogs	dog	NOUN
admet-341	207	19	(	(	PUNCT
admet-341	207	20	figures	figure	NOUN
admet-341	207	21	3	3	NUM
admet-341	207	22	,	,	PUNCT
admet-341	207	23	4	4	NUM
admet-341	207	24	and	and	CCONJ
admet-341	207	25	6	6	NUM
admet-341	207	26	)	)	PUNCT
admet-341	207	27	.	.	PUNCT
admet-341	208	1	potential	potential	ADJ
admet-341	208	2	causes	cause	NOUN
admet-341	208	3	for	for	ADP
admet-341	208	4	the	the	DET
admet-341	208	5	low	low	ADJ
admet-341	208	6	oral	oral	ADJ
admet-341	208	7	bioavailability	bioavailability	NOUN
admet-341	208	8	could	could	AUX
admet-341	208	9	be	be	AUX
admet-341	208	10	due	due	ADJ
admet-341	208	11	to	to	ADP
admet-341	208	12	metabolism	metabolism	NOUN
admet-341	208	13	in	in	ADP
admet-341	208	14	the	the	DET
admet-341	208	15	gut	gut	NOUN
admet-341	208	16	wall	wall	NOUN
admet-341	208	17	,	,	PUNCT
admet-341	208	18	and	and	CCONJ
admet-341	208	19	first	first	ADJ
admet-341	208	20	-	-	PUNCT
admet-341	208	21	pass	pass	VERB
admet-341	208	22	metabolism	metabolism	NOUN
admet-341	208	23	in	in	ADP
admet-341	208	24	the	the	DET
admet-341	208	25	liver	liver	NOUN
admet-341	208	26	[	[	X
admet-341	208	27	17	17	NUM
admet-341	208	28	-	-	SYM
admet-341	208	29	19	19	NUM
admet-341	208	30	]	]	PUNCT
admet-341	208	31	.	.	PUNCT
admet-341	209	1	following	follow	VERB
admet-341	209	2	intravenous	intravenous	ADJ
admet-341	209	3	dosing	dose	VERB
admet-341	209	4	to	to	ADP
admet-341	209	5	mice	mouse	NOUN
admet-341	209	6	,	,	PUNCT
admet-341	209	7	rats	rat	NOUN
admet-341	209	8	and	and	CCONJ
admet-341	209	9	dogs	dog	NOUN
admet-341	209	10	,	,	PUNCT
admet-341	209	11	gbo-006	gbo-006	NOUN
admet-341	209	12	is	be	AUX
admet-341	209	13	rapidly	rapidly	ADV
admet-341	209	14	eliminated	eliminate	VERB
admet-341	209	15	from	from	ADP
admet-341	209	16	plasma	plasma	NOUN
admet-341	209	17	within	within	ADP
admet-341	209	18	the	the	DET
admet-341	209	19	first	first	ADJ
admet-341	209	20	several	several	ADJ
admet-341	209	21	hours	hour	NOUN
admet-341	209	22	with	with	ADP
admet-341	209	23	half	half	ADJ
admet-341	209	24	-	-	PUNCT
admet-341	209	25	life	life	NOUN
admet-341	209	26	estimates	estimate	NOUN
admet-341	209	27	ranging	range	VERB
admet-341	209	28	from	from	ADP
admet-341	209	29	0.5	0.5	NUM
admet-341	209	30	to	to	ADP
admet-341	209	31	0.7	0.7	NUM
admet-341	209	32	h	h	NOUN
admet-341	209	33	over	over	ADP
admet-341	209	34	this	this	DET
admet-341	209	35	period	period	NOUN
admet-341	209	36	.	.	PUNCT
admet-341	210	1	overall	overall	ADV
admet-341	210	2	,	,	PUNCT
admet-341	210	3	gbo-006	gbo-006	ADJ
admet-341	210	4	pharmacokinetics	pharmacokinetic	NOUN
admet-341	210	5	was	be	AUX
admet-341	210	6	comparable	comparable	ADJ
admet-341	210	7	across	across	ADP
admet-341	210	8	the	the	DET
admet-341	210	9	three	three	NUM
admet-341	210	10	species	specie	NOUN
admet-341	210	11	tested	test	VERB
admet-341	210	12	.	.	PUNCT
admet-341	211	1	clearance	clearance	NOUN
admet-341	211	2	,	,	PUNCT
admet-341	211	3	the	the	DET
admet-341	211	4	critical	critical	ADJ
admet-341	211	5	connection	connection	NOUN
admet-341	211	6	between	between	ADP
admet-341	211	7	the	the	DET
admet-341	211	8	administered	administer	VERB
admet-341	211	9	dose	dose	NOUN
admet-341	211	10	and	and	CCONJ
admet-341	211	11	drug	drug	NOUN
admet-341	211	12	exposure	exposure	NOUN
admet-341	211	13	(	(	PUNCT
admet-341	211	14	auc	auc	NOUN
admet-341	211	15	)	)	PUNCT
admet-341	211	16	,	,	PUNCT
admet-341	211	17	was	be	AUX
admet-341	211	18	very	very	ADV
admet-341	211	19	high	high	ADJ
admet-341	211	20	(	(	PUNCT
admet-341	211	21	which	which	PRON
admet-341	211	22	is	be	AUX
admet-341	211	23	more	more	ADJ
admet-341	211	24	than	than	ADP
admet-341	211	25	hepatic	hepatic	ADJ
admet-341	211	26	blood	blood	NOUN
admet-341	211	27	volume	volume	NOUN
admet-341	211	28	)	)	PUNCT
admet-341	211	29	and	and	CCONJ
admet-341	211	30	consistent	consistent	ADJ
admet-341	211	31	among	among	ADP
admet-341	211	32	mouse	mouse	NOUN
admet-341	211	33	and	and	CCONJ
admet-341	211	34	dog	dog	NOUN
admet-341	211	35	.	.	PUNCT
admet-341	212	1	single	single	ADJ
admet-341	212	2	day	day	NOUN
admet-341	212	3	dose	dose	NOUN
admet-341	212	4	escalation	escalation	NOUN
admet-341	212	5	study	study	NOUN
admet-341	212	6	by	by	ADP
admet-341	212	7	intraperitoneal	intraperitoneal	ADJ
admet-341	212	8	route	route	NOUN
admet-341	212	9	demonstrated	demonstrate	VERB
admet-341	212	10	the	the	DET
admet-341	212	11	dose	dose	ADJ
admet-341	212	12	proportional	proportional	ADJ
admet-341	212	13	increase	increase	NOUN
admet-341	212	14	in	in	ADP
admet-341	212	15	auc	auc	NOUN
admet-341	212	16	and	and	CCONJ
admet-341	212	17	cmax	cmax	VERB
admet-341	212	18	,	,	PUNCT
admet-341	212	19	thus	thus	ADV
admet-341	212	20	displaying	display	VERB
admet-341	212	21	linear	linear	ADJ
admet-341	212	22	pharmacokinetics	pharmacokinetic	NOUN
admet-341	212	23	.	.	PUNCT
admet-341	213	1	since	since	SCONJ
admet-341	213	2	linear	linear	PROPN
admet-341	213	3	exposure	exposure	NOUN
admet-341	213	4	was	be	AUX
admet-341	213	5	observed	observe	VERB
admet-341	213	6	in	in	ADP
admet-341	213	7	mice	mouse	NOUN
admet-341	213	8	,	,	PUNCT
admet-341	213	9	30	30	NUM
admet-341	213	10	and	and	CCONJ
admet-341	213	11	75	75	NUM
admet-341	213	12	mg	mg	NUM
admet-341	213	13	/	/	SYM
admet-341	213	14	kg	kg	PROPN
admet-341	213	15	were	be	AUX
admet-341	213	16	selected	select	VERB
admet-341	213	17	for	for	ADP
admet-341	213	18	xenograft	xenograft	NOUN
admet-341	213	19	study	study	PROPN
admet-341	213	20	,	,	PUNCT
admet-341	213	21	where	where	SCONJ
admet-341	213	22	30	30	NUM
admet-341	213	23	mg	mg	NUM
admet-341	213	24	/	/	SYM
admet-341	213	25	kg	kg	PROPN
admet-341	213	26	dose	dose	NOUN
admet-341	213	27	showed	show	VERB
admet-341	213	28	greater	great	ADJ
admet-341	213	29	than	than	ADP
admet-341	213	30	50	50	NUM
admet-341	213	31	%	%	NOUN
admet-341	213	32	tumor	tumor	NOUN
admet-341	213	33	regression	regression	NOUN
admet-341	213	34	.	.	PUNCT
admet-341	214	1	further	further	ADJ
admet-341	214	2	studies	study	NOUN
admet-341	214	3	are	be	AUX
admet-341	214	4	required	require	VERB
admet-341	214	5	to	to	PART
admet-341	214	6	compare	compare	VERB
admet-341	214	7	the	the	DET
admet-341	214	8	efficacy	efficacy	NOUN
admet-341	214	9	dosage	dosage	NOUN
admet-341	214	10	in	in	ADP
admet-341	214	11	mice	mouse	NOUN
admet-341	214	12	to	to	ADP
admet-341	214	13	adverse	adverse	ADJ
admet-341	214	14	dosage	dosage	NOUN
admet-341	214	15	effects	effect	NOUN
admet-341	214	16	in	in	ADP
admet-341	214	17	rat	rat	NOUN
admet-341	214	18	,	,	PUNCT
admet-341	214	19	for	for	ADP
admet-341	214	20	non	non	ADJ
admet-341	214	21	-	-	ADJ
admet-341	214	22	clinical	clinical	ADJ
admet-341	214	23	risk	risk	NOUN
admet-341	214	24	assessment	assessment	NOUN
admet-341	214	25	.	.	PUNCT
admet-341	215	1	current	current	ADJ
admet-341	215	2	efforts	effort	NOUN
admet-341	215	3	are	be	AUX
admet-341	215	4	focusing	focus	VERB
admet-341	215	5	on	on	ADP
admet-341	215	6	formulation	formulation	NOUN
admet-341	215	7	studies	study	NOUN
admet-341	215	8	that	that	PRON
admet-341	215	9	would	would	AUX
admet-341	215	10	enable	enable	VERB
admet-341	215	11	us	we	PRON
admet-341	215	12	to	to	PART
admet-341	215	13	carry	carry	VERB
admet-341	215	14	out	out	ADP
admet-341	215	15	glp	glp	NOUN
admet-341	215	16	tox	tox	NOUN
admet-341	215	17	at	at	ADP
admet-341	215	18	higher	high	ADJ
admet-341	215	19	doses	dose	NOUN
admet-341	215	20	of	of	ADP
admet-341	215	21	gbo-006	gbo-006	NOUN
admet-341	215	22	.	.	PUNCT
admet-341	216	1	acknowledgements	acknowledgement	NOUN
admet-341	216	2	we	we	PRON
admet-341	216	3	gratefully	gratefully	ADV
admet-341	216	4	acknowledge	acknowledge	VERB
admet-341	216	5	the	the	DET
admet-341	216	6	thoughtful	thoughtful	ADJ
admet-341	216	7	suggestions	suggestion	NOUN
admet-341	216	8	and	and	CCONJ
admet-341	216	9	constructive	constructive	ADJ
admet-341	216	10	criticism	criticism	NOUN
admet-341	216	11	from	from	ADP
admet-341	216	12	e.	e.	PROPN
admet-341	216	13	p.	p.	PROPN
admet-341	216	14	reddy	reddy	PROPN
admet-341	216	15	was	be	AUX
admet-341	216	16	supported	support	VERB
admet-341	216	17	by	by	ADP
admet-341	216	18	ca158209	ca158209	NOUN
admet-341	216	19	.	.	PUNCT
admet-341	217	1	conflict	conflict	NOUN
admet-341	217	2	of	of	ADP
admet-341	217	3	interest	interest	NOUN
admet-341	217	4	the	the	DET
admet-341	217	5	authors	author	NOUN
admet-341	217	6	declare	declare	VERB
admet-341	217	7	that	that	SCONJ
admet-341	217	8	they	they	PRON
admet-341	217	9	have	have	VERB
admet-341	217	10	no	no	DET
admet-341	217	11	conflict	conflict	NOUN
admet-341	217	12	of	of	ADP
admet-341	217	13	interest	interest	NOUN
admet-341	217	14	.	.	PUNCT
admet-341	218	1	references	reference	NOUN
admet-341	218	2	[	[	X
admet-341	218	3	1	1	NUM
admet-341	218	4	]	]	X
admet-341	218	5	n.	n.	PROPN
admet-341	218	6	takai	takai	PROPN
admet-341	218	7	,	,	PUNCT
admet-341	218	8	r.	r.	PROPN
admet-341	218	9	hamanaka	hamanaka	PROPN
admet-341	218	10	,	,	PUNCT
admet-341	218	11	j.	j.	PROPN
admet-341	218	12	yoshimatsu	yoshimatsu	PROPN
admet-341	218	13	,	,	PUNCT
admet-341	218	14	i.	i.	PROPN
admet-341	218	15	miyakawa	miyakawa	PROPN
admet-341	218	16	,	,	PUNCT
admet-341	218	17	oncogene	oncogene	NOUN
admet-341	218	18	24	24	NUM
admet-341	218	19	(	(	PUNCT
admet-341	218	20	2005	2005	NUM
admet-341	218	21	)	)	PUNCT
admet-341	219	1	287–291	287–291	NUM
admet-341	219	2	.	.	PUNCT
admet-341	220	1	[	[	X
admet-341	220	2	2	2	NUM
admet-341	220	3	]	]	PUNCT
admet-341	220	4	p.	p.	PROPN
admet-341	220	5	chopra	chopra	PROPN
admet-341	220	6	,	,	PUNCT
admet-341	220	7	g.	g.	PROPN
admet-341	220	8	sethi	sethi	PROPN
admet-341	220	9	,	,	PUNCT
admet-341	220	10	s.g	s.g	PROPN
admet-341	220	11	.	.	PROPN
admet-341	220	12	dastidar	dastidar	PROPN
admet-341	220	13	,	,	PUNCT
admet-341	220	14	a.	a.	NOUN
admet-341	220	15	ray	ray	PROPN
admet-341	220	16	,	,	PUNCT
admet-341	220	17	expert	expert	NOUN
admet-341	220	18	opin	opin	NOUN
admet-341	220	19	.	.	PUNCT
admet-341	220	20	investig	investig	NOUN
admet-341	220	21	.	.	PUNCT
admet-341	221	1	drugs	drug	NOUN
admet-341	221	2	19	19	NUM
admet-341	221	3	(	(	PUNCT
admet-341	221	4	2010	2010	NUM
admet-341	221	5	)	)	PUNCT
admet-341	221	6	27	27	NUM
admet-341	221	7	-	-	SYM
admet-341	221	8	43	43	NUM
admet-341	221	9	.	.	PUNCT
admet-341	222	1	[	[	X
admet-341	222	2	3	3	X
admet-341	222	3	]	]	X
admet-341	222	4	e.m	e.m	PROPN
admet-341	222	5	.	.	PROPN
admet-341	222	6	matthew	matthew	PROPN
admet-341	222	7	,	,	PUNCT
admet-341	222	8	l.s	l.s	PROPN
admet-341	222	9	.	.	PROPN
admet-341	222	10	hart	hart	PROPN
admet-341	222	11	,	,	PUNCT
admet-341	222	12	a.	a.	PROPN
admet-341	222	13	astrinidis	astrinidis	PROPN
admet-341	222	14	,	,	PUNCT
admet-341	222	15	a.	a.	PROPN
admet-341	222	16	navaraj	navaraj	PROPN
admet-341	222	17	,	,	PUNCT
admet-341	222	18	n.g	n.g	PROPN
admet-341	222	19	.	.	PROPN
admet-341	222	20	dolloff	dolloff	PROPN
admet-341	222	21	,	,	PUNCT
admet-341	222	22	d.t	d.t	PROPN
admet-341	222	23	.	.	PROPN
admet-341	222	24	dicker	dicker	PROPN
admet-341	222	25	,	,	PUNCT
admet-341	222	26	e.p	e.p	PROPN
admet-341	222	27	.	.	PROPN
admet-341	222	28	henske	henske	PROPN
admet-341	222	29	,	,	PUNCT
admet-341	222	30	w.s	w.s	PROPN
admet-341	222	31	.	.	PROPN
admet-341	222	32	eldeiry	eldeiry	NOUN
admet-341	222	33	,	,	PUNCT
admet-341	222	34	cell	cell	NOUN
admet-341	222	35	cycle	cycle	NOUN
admet-341	222	36	8	8	NUM
admet-341	222	37	(	(	PUNCT
admet-341	222	38	2009	2009	NUM
admet-341	222	39	)	)	PUNCT
admet-341	222	40	4168–4175	4168–4175	NOUN
admet-341	222	41	.	.	PUNCT
admet-341	223	1	[	[	X
admet-341	223	2	4	4	X
admet-341	223	3	]	]	X
admet-341	223	4	t.f	t.f	PROPN
admet-341	223	5	.	.	PROPN
admet-341	223	6	burns	burn	NOUN
admet-341	223	7	,	,	PUNCT
admet-341	223	8	p.	p.	PROPN
admet-341	223	9	fei	fei	PROPN
admet-341	223	10	,	,	PUNCT
admet-341	223	11	k.a	k.a	PROPN
admet-341	223	12	.	.	PROPN
admet-341	223	13	scata	scata	PROPN
admet-341	223	14	,	,	PUNCT
admet-341	223	15	d.t	d.t	PROPN
admet-341	223	16	.	.	PROPN
admet-341	223	17	dicker	dicker	PROPN
admet-341	223	18	,	,	PUNCT
admet-341	223	19	w.s	w.s	PROPN
admet-341	223	20	.	.	PROPN
admet-341	224	1	el	el	NOUN
admet-341	224	2	-	-	PUNCT
admet-341	224	3	deiry	deiry	PROPN
admet-341	224	4	,	,	PUNCT
admet-341	224	5	mol	mol	NOUN
admet-341	224	6	.	.	PROPN
admet-341	224	7	cell	cell	NOUN
admet-341	224	8	biol	biol	PROPN
admet-341	224	9	.	.	PUNCT
admet-341	225	1	23	23	NUM
admet-341	225	2	(	(	PUNCT
admet-341	225	3	2003	2003	NUM
admet-341	225	4	)	)	PUNCT
admet-341	226	1	5556–5571	5556–5571	NOUN
admet-341	226	2	.	.	PUNCT
admet-341	227	1	[	[	X
admet-341	227	2	5	5	X
admet-341	227	3	]	]	PUNCT
admet-341	227	4	s.	s.	PROPN
admet-341	227	5	warnke	warnke	PROPN
admet-341	227	6	,	,	PUNCT
admet-341	227	7	s.	s.	PROPN
admet-341	227	8	kemmler	kemmler	PROPN
admet-341	227	9	,	,	PUNCT
admet-341	227	10	r.s	r.s	PROPN
admet-341	227	11	.	.	PROPN
admet-341	227	12	hames	hames	PROPN
admet-341	227	13	,	,	PUNCT
admet-341	227	14	h.l	h.l	PROPN
admet-341	227	15	.	.	PROPN
admet-341	227	16	tsai	tsai	PROPN
admet-341	227	17	,	,	PUNCT
admet-341	227	18	u.	u.	PROPN
admet-341	227	19	hoffmann	hoffmann	PROPN
admet-341	227	20	-	-	PUNCT
admet-341	227	21	rohrer	rohrer	PROPN
admet-341	227	22	,	,	PUNCT
admet-341	227	23	a.m.	a.m.	PROPN
admet-341	227	24	fry	fry	PROPN
admet-341	227	25	,	,	PUNCT
admet-341	227	26	curr	curr	PROPN
admet-341	227	27	.	.	PUNCT
admet-341	228	1	biol	biol	PROPN
admet-341	228	2	.	.	PUNCT
admet-341	229	1	14	14	NUM
admet-341	229	2	(	(	PUNCT
admet-341	229	3	2004	2004	NUM
admet-341	229	4	)	)	PUNCT
admet-341	229	5	1200–1207	1200–1207	NUM
admet-341	229	6	.	.	PUNCT
admet-341	230	1	[	[	X
admet-341	230	2	6	6	NUM
admet-341	230	3	]	]	PUNCT
admet-341	230	4	t.	t.	PROPN
admet-341	230	5	lu	lu	PROPN
admet-341	230	6	,	,	PUNCT
admet-341	230	7	c.a	c.a	PROPN
admet-341	230	8	.	.	PROPN
admet-341	230	9	laughton	laughton	PROPN
admet-341	230	10	,	,	PUNCT
admet-341	230	11	s.	s.	PROPN
admet-341	230	12	wang	wang	PROPN
admet-341	230	13	,	,	PUNCT
admet-341	230	14	t.d	t.d	PROPN
admet-341	230	15	.	.	PROPN
admet-341	230	16	bradshaw	bradshaw	PROPN
admet-341	230	17	,	,	PUNCT
admet-341	230	18	mol	mol	PROPN
admet-341	230	19	.	.	PUNCT
admet-341	230	20	pharmacol	pharmacol	PROPN
admet-341	230	21	.	.	PUNCT
admet-341	231	1	87	87	NUM
admet-341	231	2	(	(	PUNCT
admet-341	231	3	2015	2015	NUM
admet-341	231	4	)	)	PUNCT
admet-341	231	5	18	18	NUM
admet-341	231	6	-	-	SYM
admet-341	231	7	30	30	NUM
admet-341	231	8	.	.	PUNCT
admet-341	232	1	[	[	X
admet-341	232	2	7	7	X
admet-341	232	3	]	]	X
admet-341	232	4	j.p	j.p	PROPN
admet-341	232	5	.	.	PROPN
admet-341	232	6	zhang	zhang	PROPN
admet-341	232	7	,	,	PUNCT
admet-341	232	8	j.	j.	PROPN
admet-341	232	9	huang	huang	PROPN
admet-341	232	10	,	,	PUNCT
admet-341	232	11	c.	c.	PROPN
admet-341	232	12	liu	liu	PROPN
admet-341	232	13	,	,	PUNCT
admet-341	232	14	x.f	x.f	PROPN
admet-341	232	15	.	.	PROPN
admet-341	232	16	lu	lu	PROPN
admet-341	232	17	,	,	PUNCT
admet-341	232	18	b.x	b.x	PROPN
admet-341	232	19	.	.	PROPN
admet-341	232	20	wu	wu	PROPN
admet-341	232	21	,	,	PUNCT
admet-341	232	22	l.	l.	PROPN
admet-341	232	23	zhao	zhao	PROPN
admet-341	232	24	,	,	PUNCT
admet-341	232	25	n.	n.	PROPN
admet-341	232	26	lu	lu	PROPN
admet-341	232	27	,	,	PUNCT
admet-341	232	28	q.l	q.l	PROPN
admet-341	232	29	.	.	PUNCT
admet-341	232	30	guo	guo	PROPN
admet-341	232	31	,	,	PUNCT
admet-341	232	32	z.y	z.y	PROPN
admet-341	232	33	.	.	PROPN
admet-341	232	34	li	li	PROPN
admet-341	232	35	,	,	PUNCT
admet-341	232	36	c.	c.	PROPN
admet-341	232	37	jiang	jiang	PROPN
admet-341	232	38	,	,	PUNCT
admet-341	232	39	chinese	chinese	ADJ
admet-341	232	40	chemical	chemical	NOUN
admet-341	232	41	letters	letter	NOUN
admet-341	232	42	25	25	NUM
admet-341	232	43	(	(	PUNCT
admet-341	232	44	2014	2014	NUM
admet-341	232	45	)	)	PUNCT
admet-341	232	46	1025–1028	1025–1028	NUM
admet-341	232	47	.	.	PUNCT
admet-341	233	1	[	[	X
admet-341	233	2	8	8	NUM
admet-341	233	3	]	]	PUNCT
admet-341	233	4	s.	s.	PROPN
admet-341	233	5	cockerill	cockerill	PROPN
admet-341	233	6	,	,	PUNCT
admet-341	233	7	c.	c.	PROPN
admet-341	233	8	stubberfield	stubberfield	PROPN
admet-341	233	9	,	,	PUNCT
admet-341	233	10	j.	j.	PROPN
admet-341	233	11	stables	stables	PROPN
admet-341	233	12	,	,	PUNCT
admet-341	233	13	m.	m.	NOUN
admet-341	233	14	carter	carter	PROPN
admet-341	233	15	,	,	PUNCT
admet-341	233	16	s.	s.	PROPN
admet-341	233	17	guntrip	guntrip	PROPN
admet-341	233	18	,	,	PUNCT
admet-341	233	19	k.	k.	PROPN
admet-341	233	20	smith	smith	PROPN
admet-341	233	21	,	,	PUNCT
admet-341	233	22	s.	s.	PROPN
admet-341	233	23	mckeown	mckeown	PROPN
admet-341	233	24	,	,	PUNCT
admet-341	233	25	r.	r.	PROPN
admet-341	233	26	shaw	shaw	PROPN
admet-341	233	27	,	,	PUNCT
admet-341	233	28	p.	p.	NOUN
admet-341	233	29	topley	topley	NOUN
admet-341	233	30	,	,	PUNCT
admet-341	233	31	l.	l.	PROPN
admet-341	233	32	thomsen	thomsen	PROPN
admet-341	233	33	,	,	PUNCT
admet-341	233	34	k.	k.	PROPN
admet-341	233	35	affleck	affleck	PROPN
admet-341	233	36	,	,	PUNCT
admet-341	233	37	a.	a.	PROPN
admet-341	233	38	jowett	jowett	PROPN
admet-341	233	39	,	,	PUNCT
admet-341	233	40	d.	d.	PROPN
admet-341	233	41	hayes	hayes	PROPN
admet-341	233	42	,	,	PUNCT
admet-341	233	43	m.	m.	PROPN
admet-341	233	44	willson	willson	PROPN
admet-341	233	45	,	,	PUNCT
admet-341	233	46	p.	p.	PROPN
admet-341	233	47	woollard	woollard	PROPN
admet-341	233	48	,	,	PUNCT
admet-341	233	49	d.	d.	PROPN
admet-341	233	50	spalding	spalding	PROPN
admet-341	233	51	,	,	PUNCT
admet-341	233	52	bioorganic	bioorganic	PROPN
admet-341	233	53	&	&	CCONJ
admet-341	233	54	medicinal	medicinal	ADJ
admet-341	233	55	chemistry	chemistry	NOUN
admet-341	233	56	letters	letter	NOUN
admet-341	233	57	11	11	NUM
admet-341	233	58	(	(	PUNCT
admet-341	233	59	2001	2001	NUM
admet-341	233	60	)	)	PUNCT
admet-341	233	61	1401–1405	1401–1405	NUM
admet-341	233	62	.	.	PUNCT
admet-341	234	1	srinivas	srinivas	PROPN
admet-341	234	2	maddi	maddi	PROPN
admet-341	234	3	et	et	PROPN
admet-341	234	4	al	al	PROPN
admet-341	234	5	.	.	PROPN
admet-341	234	6	admet	admet	PROPN
admet-341	234	7	&	&	CCONJ
admet-341	234	8	dmpk	dmpk	PROPN
admet-341	234	9	4(4	4(4	NUM
admet-341	234	10	)	)	PUNCT
admet-341	234	11	(	(	PUNCT
admet-341	234	12	2016	2016	NUM
admet-341	234	13	)	)	PUNCT
admet-341	234	14	314	314	NUM
admet-341	234	15	-	-	SYM
admet-341	234	16	326	326	NUM
admet-341	234	17	326	326	NUM
admet-341	234	18	[	[	PUNCT
admet-341	234	19	9	9	NUM
admet-341	234	20	]	]	X
admet-341	234	21	m.v	m.v	PROPN
admet-341	234	22	.	.	PROPN
admet-341	234	23	reddy	reddy	PROPN
admet-341	234	24	,	,	PUNCT
admet-341	234	25	b.	b.	PROPN
admet-341	234	26	akula	akula	PROPN
admet-341	234	27	,	,	PUNCT
admet-341	234	28	s.	s.	PROPN
admet-341	234	29	jatiani	jatiani	PROPN
admet-341	234	30	,	,	PUNCT
admet-341	234	31	r.	r.	PROPN
admet-341	234	32	vasquez	vasquez	PROPN
admet-341	234	33	-	-	PUNCT
admet-341	234	34	del	del	PROPN
admet-341	234	35	carpio	carpio	NOUN
admet-341	234	36	,	,	PUNCT
admet-341	234	37	v.k	v.k	PROPN
admet-341	234	38	.	.	PROPN
admet-341	234	39	billa	billa	PROPN
admet-341	234	40	,	,	PUNCT
admet-341	234	41	m.r	m.r	PROPN
admet-341	234	42	.	.	PROPN
admet-341	234	43	mallireddigari	mallireddigari	PROPN
admet-341	234	44	,	,	PUNCT
admet-341	234	45	s.c	s.c	PROPN
admet-341	234	46	.	.	PROPN
admet-341	234	47	cosenza	cosenza	PROPN
admet-341	234	48	,	,	PUNCT
admet-341	234	49	d.r	d.r	PROPN
admet-341	234	50	.	.	PROPN
admet-341	234	51	venkata	venkata	PROPN
admet-341	234	52	subbaiah	subbaiah	PROPN
admet-341	234	53	,	,	PUNCT
admet-341	234	54	e.v	e.v	PROPN
admet-341	234	55	.	.	PUNCT
admet-341	234	56	bharathi	bharathi	PROPN
admet-341	234	57	,	,	PUNCT
admet-341	234	58	v.r	v.r	PROPN
admet-341	234	59	.	.	PROPN
admet-341	234	60	pallela	pallela	PROPN
admet-341	234	61	,	,	PUNCT
admet-341	234	62	p.	p.	PROPN
admet-341	234	63	ramkumar	ramkumar	PROPN
admet-341	234	64	,	,	PUNCT
admet-341	234	65	r.	r.	PROPN
admet-341	234	66	jain	jain	PROPN
admet-341	234	67	,	,	PUNCT
admet-341	234	68	a.k	a.k	PROPN
admet-341	234	69	.	.	PROPN
admet-341	234	70	aggarwal	aggarwal	PROPN
admet-341	234	71	,	,	PUNCT
admet-341	234	72	e.p	e.p	PROPN
admet-341	234	73	.	.	PROPN
admet-341	234	74	reddy	reddy	PROPN
admet-341	234	75	,	,	PUNCT
admet-341	234	76	bioorg	bioorg	PROPN
admet-341	234	77	.	.	PUNCT
admet-341	235	1	med	med	PROPN
admet-341	235	2	.	.	PROPN
admet-341	235	3	chem	chem	PROPN
admet-341	235	4	.	.	PUNCT
admet-341	236	1	24	24	NUM
admet-341	236	2	(	(	PUNCT
admet-341	236	3	2016	2016	NUM
admet-341	236	4	)	)	PUNCT
admet-341	236	5	521	521	NUM
admet-341	236	6	-	-	SYM
admet-341	236	7	544	544	NUM
admet-341	236	8	.	.	PUNCT
admet-341	237	1	[	[	X
admet-341	237	2	10	10	NUM
admet-341	237	3	]	]	X
admet-341	237	4	m.k	m.k	X
admet-341	237	5	.	.	PUNCT
admet-341	238	1	you	you	PRON
admet-341	238	2	,	,	PUNCT
admet-341	238	3	m.s	m.s	PROPN
admet-341	238	4	.	.	PROPN
admet-341	238	5	kim	kim	PROPN
admet-341	238	6	,	,	PUNCT
admet-341	238	7	k.s	k.s	PROPN
admet-341	238	8	.	.	PROPN
admet-341	238	9	jeong	jeong	PROPN
admet-341	238	10	,	,	PUNCT
admet-341	238	11	e.	e.	PROPN
admet-341	238	12	kim	kim	PROPN
admet-341	238	13	,	,	PUNCT
admet-341	238	14	y.j	y.j	PROPN
admet-341	238	15	.	.	PUNCT
admet-341	238	16	kim	kim	PROPN
admet-341	238	17	,	,	PUNCT
admet-341	238	18	h.a	h.a	PROPN
admet-341	238	19	.	.	PROPN
admet-341	238	20	kim	kim	PROPN
admet-341	238	21	,	,	PUNCT
admet-341	238	22	nutrition	nutrition	NOUN
admet-341	238	23	research	research	NOUN
admet-341	238	24	and	and	CCONJ
admet-341	238	25	practice	practice	NOUN
admet-341	238	26	10	10	NUM
admet-341	238	27	(	(	PUNCT
admet-341	238	28	2016	2016	NUM
admet-341	238	29	)	)	PUNCT
admet-341	238	30	139	139	NUM
admet-341	238	31	-	-	SYM
admet-341	238	32	147	147	NUM
admet-341	238	33	.	.	PUNCT
admet-341	239	1	[	[	X
admet-341	239	2	11	11	NUM
admet-341	239	3	]	]	X
admet-341	239	4	v.	v.	PROPN
admet-341	239	5	archambault	archambault	PROPN
admet-341	239	6	,	,	PUNCT
admet-341	239	7	d.m	d.m	PROPN
admet-341	239	8	.	.	PROPN
admet-341	239	9	glover	glover	PROPN
admet-341	239	10	,	,	PUNCT
admet-341	239	11	nat	nat	PROPN
admet-341	239	12	.	.	PUNCT
admet-341	239	13	rev	rev	PROPN
admet-341	239	14	.	.	PROPN
admet-341	239	15	mol	mol	PROPN
admet-341	239	16	.	.	PROPN
admet-341	239	17	cell	cell	PROPN
admet-341	239	18	biol	biol	PROPN
admet-341	239	19	.	.	PUNCT
admet-341	240	1	10	10	NUM
admet-341	240	2	(	(	PUNCT
admet-341	240	3	2009	2009	NUM
admet-341	240	4	)	)	PUNCT
admet-341	240	5	265	265	NUM
admet-341	240	6	-	-	SYM
admet-341	240	7	275	275	NUM
admet-341	240	8	.	.	PUNCT
admet-341	241	1	[	[	X
admet-341	241	2	12	12	NUM
admet-341	241	3	]	]	PUNCT
admet-341	241	4	k.	k.	PROPN
admet-341	241	5	strebhardt	strebhardt	PROPN
admet-341	241	6	,	,	PUNCT
admet-341	241	7	nat	nat	PROPN
admet-341	241	8	.	.	PUNCT
admet-341	242	1	rev	rev	PROPN
admet-341	242	2	.	.	PROPN
admet-341	242	3	drug	drug	NOUN
admet-341	242	4	discov	discov	NOUN
admet-341	242	5	.	.	PUNCT
admet-341	243	1	9	9	NUM
admet-341	243	2	(	(	PUNCT
admet-341	243	3	2010	2010	NUM
admet-341	243	4	)	)	PUNCT
admet-341	243	5	643	643	NUM
admet-341	243	6	-	-	SYM
admet-341	243	7	6600	6600	NUM
admet-341	243	8	.	.	PUNCT
admet-341	244	1	[	[	X
admet-341	244	2	13	13	NUM
admet-341	244	3	]	]	X
admet-341	244	4	o.	o.	PROPN
admet-341	244	5	cizmecioglu	cizmecioglu	PROPN
admet-341	244	6	,	,	PUNCT
admet-341	244	7	a.	a.	NOUN
admet-341	244	8	krause	krause	PROPN
admet-341	244	9	,	,	PUNCT
admet-341	244	10	r.	r.	PROPN
admet-341	244	11	bahtz	bahtz	PROPN
admet-341	244	12	,	,	PUNCT
admet-341	244	13	l.	l.	PROPN
admet-341	244	14	ehret	ehret	PROPN
admet-341	244	15	,	,	PUNCT
admet-341	244	16	n.	n.	PROPN
admet-341	244	17	malek	malek	PROPN
admet-341	244	18	,	,	PUNCT
admet-341	244	19	i.	i.	PROPN
admet-341	244	20	hoffmann	hoffmann	PROPN
admet-341	244	21	.	.	PUNCT
admet-341	245	1	j.	j.	PROPN
admet-341	245	2	cell	cell	PROPN
admet-341	245	3	sci	sci	PROPN
admet-341	245	4	.	.	PROPN
admet-341	246	1	125	125	NUM
admet-341	246	2	(	(	PUNCT
admet-341	246	3	2012	2012	NUM
admet-341	246	4	)	)	PUNCT
admet-341	246	5	981	981	NUM
admet-341	246	6	-	-	SYM
admet-341	246	7	992	992	NUM
admet-341	246	8	.	.	PUNCT
admet-341	247	1	[	[	X
admet-341	247	2	14	14	NUM
admet-341	247	3	]	]	PUNCT
admet-341	247	4	t.	t.	PROPN
admet-341	247	5	matsumoto	matsumoto	PROPN
admet-341	247	6	,	,	PUNCT
admet-341	247	7	p.y	p.y	PROPN
admet-341	247	8	.	.	PROPN
admet-341	247	9	wang	wang	PROPN
admet-341	247	10	,	,	PUNCT
admet-341	247	11	w.	w.	PROPN
admet-341	247	12	ma	ma	PROPN
admet-341	247	13	,	,	PUNCT
admet-341	247	14	h.j	h.j	PROPN
admet-341	247	15	.	.	PROPN
admet-341	247	16	sung	sung	PROPN
admet-341	247	17	,	,	PUNCT
admet-341	247	18	s.	s.	PROPN
admet-341	247	19	matoba	matoba	PROPN
admet-341	247	20	,	,	PUNCT
admet-341	247	21	p.m.	p.m.	PROPN
admet-341	247	22	hwang	hwang	PROPN
admet-341	247	23	,	,	PUNCT
admet-341	247	24	proc	proc	PROPN
admet-341	247	25	.	.	PUNCT
admet-341	248	1	natl	natl	PROPN
admet-341	248	2	.	.	PUNCT
admet-341	249	1	acad	acad	PROPN
admet-341	249	2	.	.	PUNCT
admet-341	250	1	sci	sci	PROPN
admet-341	250	2	.	.	PUNCT
admet-341	251	1	u	u	PROPN
admet-341	251	2	s	s	PROPN
admet-341	251	3	a.	a.	NOUN
admet-341	251	4	106	106	NUM
admet-341	251	5	(	(	PUNCT
admet-341	251	6	2009	2009	NUM
admet-341	251	7	)	)	PUNCT
admet-341	251	8	14542	14542	NUM
admet-341	251	9	-	-	SYM
admet-341	251	10	14546	14546	NUM
admet-341	251	11	.	.	PUNCT
admet-341	252	1	[	[	X
admet-341	252	2	15	15	NUM
admet-341	252	3	]	]	X
admet-341	252	4	p.k	p.k	PROPN
admet-341	252	5	.	.	PROPN
admet-341	252	6	gupta	gupta	PROPN
admet-341	252	7	,	,	PUNCT
admet-341	252	8	the	the	DET
admet-341	252	9	science	science	NOUN
admet-341	252	10	and	and	CCONJ
admet-341	252	11	practice	practice	NOUN
admet-341	252	12	of	of	ADP
admet-341	252	13	pharmacy	pharmacy	NOUN
admet-341	252	14	(	(	PUNCT
admet-341	252	15	21st	21st	NOUN
admet-341	252	16	edition	edition	NOUN
admet-341	252	17	)	)	PUNCT
admet-341	252	18	,	,	PUNCT
admet-341	252	19	remington	remington	PROPN
admet-341	252	20	,	,	PUNCT
admet-341	252	21	philadelphia	philadelphia	PROPN
admet-341	252	22	,	,	PUNCT
admet-341	252	23	usa	usa	PROPN
admet-341	252	24	,	,	PUNCT
admet-341	252	25	2005	2005	NUM
admet-341	252	26	.	.	PUNCT
admet-341	253	1	[	[	X
admet-341	253	2	16	16	NUM
admet-341	253	3	]	]	PUNCT
admet-341	253	4	m.	m.	NOUN
admet-341	253	5	sun	sun	PROPN
admet-341	253	6	,	,	PUNCT
admet-341	253	7	l.	l.	PROPN
admet-341	253	8	si	si	PROPN
admet-341	253	9	,	,	PUNCT
admet-341	253	10	x.	x.	PROPN
admet-341	253	11	zhai	zhai	PROPN
admet-341	253	12	,	,	PUNCT
admet-341	253	13	z.	z.	PROPN
admet-341	253	14	fan	fan	PROPN
admet-341	253	15	,	,	PUNCT
admet-341	253	16	y.	y.	PROPN
admet-341	253	17	ma	ma	PROPN
admet-341	253	18	,	,	PUNCT
admet-341	253	19	et	et	PROPN
admet-341	253	20	al	al	PROPN
admet-341	253	21	.	.	PROPN
admet-341	253	22	,	,	PUNCT
admet-341	253	23	drug	drug	PROPN
admet-341	253	24	dev	dev	PROPN
admet-341	253	25	.	.	PUNCT
admet-341	254	1	ind	ind	PROPN
admet-341	254	2	.	.	PUNCT
admet-341	255	1	pharm	pharm	PROPN
admet-341	255	2	.	.	PUNCT
admet-341	256	1	37	37	NUM
admet-341	256	2	(	(	PUNCT
admet-341	256	3	2011	2011	NUM
admet-341	256	4	)	)	PUNCT
admet-341	256	5	986	986	NUM
admet-341	256	6	-	-	SYM
admet-341	256	7	994	994	NUM
admet-341	256	8	.	.	PUNCT
admet-341	257	1	[	[	X
admet-341	257	2	17	17	NUM
admet-341	257	3	]	]	X
admet-341	257	4	b.s	b.s	PROPN
admet-341	257	5	.	.	PROPN
admet-341	257	6	shin	shin	PROPN
admet-341	257	7	,	,	PUNCT
admet-341	257	8	s.d.yoo	s.d.yoo	PROPN
admet-341	257	9	,	,	PUNCT
admet-341	257	10	t.h	t.h	PROPN
admet-341	257	11	.	.	PROPN
admet-341	257	12	kim	kim	PROPN
admet-341	257	13	,	,	PUNCT
admet-341	257	14	drug	drug	NOUN
admet-341	257	15	metab	metab	NOUN
admet-341	257	16	.	.	PUNCT
admet-341	258	1	dispos	dispos	PROPN
admet-341	258	2	.	.	PUNCT
admet-341	259	1	42	42	NUM
admet-341	259	2	(	(	PUNCT
admet-341	259	3	2014	2014	NUM
admet-341	259	4	)	)	PUNCT
admet-341	260	1	974–982	974–982	NUM
admet-341	260	2	.	.	PUNCT
admet-341	261	1	[	[	X
admet-341	261	2	18	18	NUM
admet-341	261	3	]	]	X
admet-341	261	4	j.m	j.m	PROPN
admet-341	261	5	.	.	PROPN
admet-341	261	6	smoliga	smoliga	PROPN
admet-341	261	7	,	,	PUNCT
admet-341	261	8	o.	o.	PROPN
admet-341	261	9	blanchard	blanchard	PROPN
admet-341	261	10	,	,	PUNCT
admet-341	261	11	molecules	molecule	NOUN
admet-341	261	12	19	19	NUM
admet-341	261	13	(	(	PUNCT
admet-341	261	14	2014	2014	NUM
admet-341	261	15	)	)	PUNCT
admet-341	261	16	17154	17154	NUM
admet-341	261	17	-	-	SYM
admet-341	261	18	17172	17172	NUM
admet-341	261	19	.	.	PUNCT
admet-341	262	1	[	[	X
admet-341	262	2	19	19	NUM
admet-341	262	3	]	]	X
admet-341	262	4	d.i	d.i	PROPN
admet-341	262	5	.	.	PROPN
admet-341	262	6	draganov	draganov	PROPN
admet-341	262	7	,	,	PUNCT
admet-341	262	8	d.a	d.a	PROPN
admet-341	262	9	.	.	PROPN
admet-341	262	10	markham	markham	PROPN
admet-341	262	11	,	,	PUNCT
admet-341	262	12	d.	d.	PROPN
admet-341	262	13	beyer	beyer	PROPN
admet-341	262	14	,	,	PUNCT
admet-341	262	15	et.al	et.al	PROPN
admet-341	262	16	.	.	PROPN
admet-341	262	17	,	,	PUNCT
admet-341	262	18	toxicology	toxicology	NOUN
admet-341	262	19	333	333	NUM
admet-341	262	20	(	(	PUNCT
admet-341	262	21	2015	2015	NUM
admet-341	262	22	)	)	PUNCT
admet-341	262	23	168–178	168–178	NUM
admet-341	262	24	.	.	PUNCT
admet-341	263	1	abbreviations	abbreviation	NOUN
admet-341	263	2	definitions	definition	NOUN
admet-341	263	3	dmso	dmso	NOUN
admet-341	263	4	dimethyl	dimethyl	NOUN
admet-341	263	5	sulfoxide	sulfoxide	PROPN
admet-341	263	6	dma	dma	PROPN
admet-341	263	7	n	n	CCONJ
admet-341	263	8	,	,	PUNCT
admet-341	263	9	n	n	CCONJ
admet-341	263	10	-	-	PUNCT
admet-341	263	11	dimethyl	dimethyl	NOUN
admet-341	263	12	acetamide	acetamide	NOUN
admet-341	263	13	lloq	lloq	VERB
admet-341	263	14	lower	low	ADJ
admet-341	263	15	limit	limit	NOUN
admet-341	263	16	of	of	ADP
admet-341	263	17	quantitation	quantitation	NOUN
admet-341	263	18	nmp	nmp	NOUN
admet-341	263	19	n	n	CCONJ
admet-341	263	20	-	-	PUNCT
admet-341	263	21	methyl	methyl	NOUN
admet-341	263	22	pyrrolidine	pyrrolidine	NOUN
admet-341	263	23	pbmn	pbmn	NOUN
admet-341	263	24	peripheral	peripheral	ADJ
admet-341	263	25	blood	blood	NOUN
admet-341	263	26	mononuclear	mononuclear	ADJ
admet-341	263	27	cells	cell	NOUN
admet-341	263	28	peg	peg	VERB
admet-341	263	29	polyethylene	polyethylene	NOUN
admet-341	263	30	glycol	glycol	NOUN
admet-341	263	31	tpgs	tpgs	NOUN
admet-341	263	32	d	d	PROPN
admet-341	263	33	alpha	alpha	NOUN
admet-341	263	34	tocopheryl	tocopheryl	NOUN
admet-341	263	35	polyethylene	polyethylene	NOUN
admet-341	263	36	glycol	glycol	NOUN
admet-341	263	37	1000	1000	NUM
admet-341	263	38	succinate	succinate	NOUN
admet-341	263	39	©	©	PROPN
admet-341	263	40	2016	2016	NUM
admet-341	263	41	by	by	ADP
admet-341	263	42	the	the	DET
admet-341	263	43	authors	author	NOUN
admet-341	263	44	;	;	PUNCT
admet-341	263	45	licensee	licensee	PROPN
admet-341	263	46	iapc	iapc	PROPN
admet-341	263	47	,	,	PUNCT
admet-341	263	48	zagreb	zagreb	PROPN
admet-341	263	49	,	,	PUNCT
admet-341	263	50	croatia	croatia	PROPN
admet-341	263	51	.	.	PUNCT
admet-341	264	1	this	this	DET
admet-341	264	2	article	article	NOUN
admet-341	264	3	is	be	AUX
admet-341	264	4	an	an	DET
admet-341	264	5	open	open	ADJ
admet-341	264	6	-	-	PUNCT
admet-341	264	7	access	access	NOUN
admet-341	264	8	article	article	NOUN
admet-341	264	9	distributed	distribute	VERB
admet-341	264	10	under	under	ADP
admet-341	264	11	the	the	DET
admet-341	264	12	terms	term	NOUN
admet-341	264	13	and	and	CCONJ
admet-341	264	14	conditions	condition	NOUN
admet-341	264	15	of	of	ADP
admet-341	264	16	the	the	DET
admet-341	264	17	creative	creative	ADJ
admet-341	264	18	commons	common	NOUN
admet-341	264	19	attribution	attribution	NOUN
admet-341	264	20	license	license	NOUN
admet-341	264	21	(	(	PUNCT
admet-341	264	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-341	264	23	)	)	PUNCT
admet-341	264	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN