id	sid	tid	token	lemma	pos
admet-36	1	1	doi	doi	NOUN
admet-36	1	2	:	:	PUNCT
admet-36	1	3	10.5599	10.5599	NUM
admet-36	1	4	/	/	SYM
admet-36	1	5	admet.2.2.36	admet.2.2.36	NOUN
admet-36	1	6	115	115	NUM
admet-36	1	7	admet	admet	PROPN
admet-36	1	8	&	&	CCONJ
admet-36	1	9	dmpk	dmpk	PROPN
admet-36	1	10	2(2	2(2	NUM
admet-36	1	11	)	)	PUNCT
admet-36	1	12	(	(	PUNCT
admet-36	1	13	2014	2014	NUM
admet-36	1	14	)	)	PUNCT
admet-36	1	15	115	115	NUM
admet-36	1	16	-	-	SYM
admet-36	1	17	125	125	NUM
admet-36	1	18	;	;	PUNCT
admet-36	1	19	doi	doi	NOUN
admet-36	1	20	:	:	PUNCT
admet-36	1	21	10.5599	10.5599	NUM
admet-36	1	22	/	/	SYM
admet-36	1	23	admet.2.2.36	admet.2.2.36	NOUN
admet-36	1	24	open	open	ADJ
admet-36	1	25	access	access	NOUN
admet-36	1	26	:	:	PUNCT
admet-36	1	27	issn	issn	PROPN
admet-36	1	28	:	:	PUNCT
admet-36	1	29	1848	1848	NUM
admet-36	1	30	-	-	SYM
admet-36	1	31	7718	7718	NUM
admet-36	1	32	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-36	1	33	original	original	ADJ
admet-36	1	34	scientific	scientific	ADJ
admet-36	1	35	paper	paper	NOUN
admet-36	1	36	diagnosing	diagnose	VERB
admet-36	1	37	solubility	solubility	NOUN
admet-36	1	38	limitations	limitation	NOUN
admet-36	1	39	–	–	PUNCT
admet-36	1	40	the	the	DET
admet-36	1	41	example	example	NOUN
admet-36	1	42	of	of	ADP
admet-36	1	43	hydrate	hydrate	ADJ
admet-36	1	44	formation	formation	NOUN
admet-36	1	45	jörg	jörg	PROPN
admet-36	1	46	berghausen	berghausen	PROPN
admet-36	1	47	*	*	PROPN
admet-36	1	48	,	,	PUNCT
admet-36	1	49	bernard	bernard	PROPN
admet-36	1	50	faller	faller	PROPN
admet-36	1	51	novartis	novartis	PROPN
admet-36	1	52	institutes	institutes	PROPN
admet-36	1	53	for	for	ADP
admet-36	1	54	biomedical	biomedical	ADJ
admet-36	1	55	research	research	NOUN
admet-36	1	56	,	,	PUNCT
admet-36	1	57	novartis	novartis	PROPN
admet-36	1	58	campus	campus	NOUN
admet-36	1	59	,	,	PUNCT
admet-36	1	60	ch-4002	ch-4002	NOUN
admet-36	1	61	basel	basel	PROPN
admet-36	1	62	*	*	PUNCT
admet-36	1	63	corresponding	correspond	VERB
admet-36	1	64	author	author	NOUN
admet-36	1	65	:	:	PUNCT
admet-36	1	66	e	e	NOUN
admet-36	1	67	-	-	NOUN
admet-36	1	68	mail	mail	NOUN
admet-36	1	69	:	:	PUNCT
admet-36	1	70	joerg.berghausen@novartis.com	joerg.berghausen@novartis.com	X
admet-36	1	71	;	;	PUNCT
admet-36	1	72	tel	tel	PROPN
admet-36	1	73	.	.	PUNCT
admet-36	1	74	:	:	PUNCT
admet-36	2	1	+41	+41	VERB
admet-36	2	2	-	-	PUNCT
admet-36	2	3	61	61	NUM
admet-36	2	4	-	-	PUNCT
admet-36	2	5	69	69	NUM
admet-36	2	6	-	-	SYM
admet-36	2	7	62335	62335	NUM
admet-36	2	8	received	receive	VERB
admet-36	2	9	:	:	PUNCT
admet-36	2	10	march	march	PROPN
admet-36	2	11	18	18	NUM
admet-36	2	12	,	,	PUNCT
admet-36	2	13	2014	2014	NUM
admet-36	2	14	;	;	PUNCT
admet-36	2	15	revised	revise	VERB
admet-36	2	16	:	:	PUNCT
admet-36	2	17	june	june	PROPN
admet-36	2	18	05	05	NUM
admet-36	2	19	,	,	PUNCT
admet-36	2	20	2014	2014	NUM
admet-36	2	21	;	;	PUNCT
admet-36	2	22	published	publish	VERB
admet-36	2	23	:	:	PUNCT
admet-36	2	24	july	july	PROPN
admet-36	2	25	18	18	NUM
admet-36	2	26	,	,	PUNCT
admet-36	2	27	2014	2014	NUM
admet-36	2	28	abstract	abstract	ADJ
admet-36	2	29	solubility	solubility	NOUN
admet-36	2	30	is	be	AUX
admet-36	2	31	regarded	regard	VERB
admet-36	2	32	as	as	ADP
admet-36	2	33	one	one	NUM
admet-36	2	34	of	of	ADP
admet-36	2	35	the	the	DET
admet-36	2	36	key	key	ADJ
admet-36	2	37	challenges	challenge	NOUN
admet-36	2	38	in	in	ADP
admet-36	2	39	many	many	ADJ
admet-36	2	40	drug	drug	NOUN
admet-36	2	41	discovery	discovery	NOUN
admet-36	2	42	projects	project	NOUN
admet-36	2	43	.	.	PUNCT
admet-36	3	1	thus	thus	ADV
admet-36	3	2	,	,	PUNCT
admet-36	3	3	it	it	PRON
admet-36	3	4	is	be	AUX
admet-36	3	5	essential	essential	ADJ
admet-36	3	6	to	to	PART
admet-36	3	7	support	support	VERB
admet-36	3	8	lead	lead	NOUN
admet-36	3	9	finding	finding	NOUN
admet-36	3	10	and	and	CCONJ
admet-36	3	11	optimization	optimization	NOUN
admet-36	3	12	efforts	effort	NOUN
admet-36	3	13	with	with	ADP
admet-36	3	14	appropriate	appropriate	ADJ
admet-36	3	15	solubility	solubility	NOUN
admet-36	3	16	data	datum	NOUN
admet-36	3	17	.	.	PUNCT
admet-36	4	1	in	in	ADP
admet-36	4	2	silico	silico	NOUN
admet-36	4	3	solubility	solubility	NOUN
admet-36	4	4	prediction	prediction	NOUN
admet-36	4	5	remains	remain	VERB
admet-36	4	6	challenging	challenging	ADJ
admet-36	4	7	and	and	CCONJ
admet-36	4	8	therefore	therefore	ADV
admet-36	4	9	a	a	DET
admet-36	4	10	screening	screening	NOUN
admet-36	4	11	assay	assay	NOUN
admet-36	4	12	is	be	AUX
admet-36	4	13	used	use	VERB
admet-36	4	14	as	as	ADP
admet-36	4	15	a	a	DET
admet-36	4	16	first	first	ADJ
admet-36	4	17	filter	filter	NOUN
admet-36	4	18	,	,	PUNCT
admet-36	4	19	followed	follow	VERB
admet-36	4	20	by	by	ADP
admet-36	4	21	selected	select	VERB
admet-36	4	22	follow	follow	NOUN
admet-36	4	23	-	-	PUNCT
admet-36	4	24	up	up	NOUN
admet-36	4	25	assays	assay	NOUN
admet-36	4	26	to	to	PART
admet-36	4	27	reveal	reveal	VERB
admet-36	4	28	what	what	PRON
admet-36	4	29	causes	cause	VERB
admet-36	4	30	the	the	DET
admet-36	4	31	low	low	ADJ
admet-36	4	32	solubility	solubility	NOUN
admet-36	4	33	of	of	ADP
admet-36	4	34	a	a	DET
admet-36	4	35	specific	specific	ADJ
admet-36	4	36	compound	compound	NOUN
admet-36	4	37	or	or	CCONJ
admet-36	4	38	chemotype	chemotype	NOUN
admet-36	4	39	.	.	PUNCT
admet-36	5	1	results	result	NOUN
admet-36	5	2	from	from	ADP
admet-36	5	3	diagnosing	diagnose	VERB
admet-36	5	4	the	the	DET
admet-36	5	5	underlying	underlying	ADJ
admet-36	5	6	reason	reason	NOUN
admet-36	5	7	for	for	ADP
admet-36	5	8	solubility	solubility	NOUN
admet-36	5	9	limitation	limitation	NOUN
admet-36	5	10	are	be	AUX
admet-36	5	11	discussed	discuss	VERB
admet-36	5	12	.	.	PUNCT
admet-36	6	1	as	as	SCONJ
admet-36	6	2	lipophilicity	lipophilicity	NOUN
admet-36	6	3	and	and	CCONJ
admet-36	6	4	crystal	crystal	NOUN
admet-36	6	5	lattice	lattice	PROPN
admet-36	6	6	forces	force	NOUN
admet-36	6	7	are	be	AUX
admet-36	6	8	regarded	regard	VERB
admet-36	6	9	as	as	ADP
admet-36	6	10	main	main	ADJ
admet-36	6	11	contributors	contributor	NOUN
admet-36	6	12	to	to	ADP
admet-36	6	13	limiting	limit	VERB
admet-36	6	14	solubility	solubility	NOUN
admet-36	6	15	,	,	PUNCT
admet-36	6	16	changes	change	NOUN
admet-36	6	17	in	in	ADP
admet-36	6	18	solid	solid	ADJ
admet-36	6	19	state	state	NOUN
admet-36	6	20	are	be	AUX
admet-36	6	21	important	important	ADJ
admet-36	6	22	to	to	PART
admet-36	6	23	be	be	AUX
admet-36	6	24	recognized	recognize	VERB
admet-36	6	25	.	.	PUNCT
admet-36	7	1	solubility	solubility	NOUN
admet-36	7	2	limitation	limitation	NOUN
admet-36	7	3	by	by	ADP
admet-36	7	4	various	various	ADJ
admet-36	7	5	factors	factor	NOUN
admet-36	7	6	will	will	AUX
admet-36	7	7	be	be	AUX
admet-36	7	8	presented	present	VERB
admet-36	7	9	and	and	CCONJ
admet-36	7	10	the	the	DET
admet-36	7	11	impact	impact	NOUN
admet-36	7	12	of	of	ADP
admet-36	7	13	the	the	DET
admet-36	7	14	solid	solid	ADJ
admet-36	7	15	-	-	PUNCT
admet-36	7	16	state	state	NOUN
admet-36	7	17	is	be	AUX
admet-36	7	18	exemplified	exemplify	VERB
admet-36	7	19	by	by	ADP
admet-36	7	20	compounds	compound	NOUN
admet-36	7	21	that	that	PRON
admet-36	7	22	are	be	AUX
admet-36	7	23	able	able	ADJ
admet-36	7	24	to	to	PART
admet-36	7	25	form	form	VERB
admet-36	7	26	hydrates	hydrate	NOUN
admet-36	7	27	.	.	PUNCT
admet-36	8	1	keywords	keyword	NOUN
admet-36	8	2	:	:	PUNCT
admet-36	8	3	polar	polar	ADJ
admet-36	8	4	surface	surface	NOUN
admet-36	8	5	area	area	NOUN
admet-36	8	6	;	;	PUNCT
admet-36	8	7	lipophilicity	lipophilicity	NOUN
admet-36	8	8	;	;	PUNCT
admet-36	8	9	crystal	crystal	NOUN
admet-36	8	10	lattice	lattice	PROPN
admet-36	8	11	energy	energy	NOUN
admet-36	8	12	introduction	introduction	NOUN
admet-36	8	13	the	the	DET
admet-36	8	14	importance	importance	NOUN
admet-36	8	15	of	of	ADP
admet-36	8	16	solubility	solubility	NOUN
admet-36	8	17	for	for	ADP
admet-36	8	18	a	a	DET
admet-36	8	19	molecule	molecule	NOUN
admet-36	8	20	to	to	PART
admet-36	8	21	become	become	VERB
admet-36	8	22	a	a	DET
admet-36	8	23	successful	successful	ADJ
admet-36	8	24	drug	drug	NOUN
admet-36	8	25	has	have	AUX
admet-36	8	26	been	be	AUX
admet-36	8	27	debated	debate	VERB
admet-36	8	28	for	for	ADP
admet-36	8	29	decades	decade	NOUN
admet-36	8	30	,	,	PUNCT
admet-36	8	31	as	as	SCONJ
admet-36	8	32	compounds	compound	NOUN
admet-36	8	33	with	with	ADP
admet-36	8	34	insufficient	insufficient	ADJ
admet-36	8	35	solubility	solubility	NOUN
admet-36	8	36	bear	bear	VERB
admet-36	8	37	a	a	DET
admet-36	8	38	higher	high	ADJ
admet-36	8	39	risk	risk	NOUN
admet-36	8	40	of	of	ADP
admet-36	8	41	attrition	attrition	NOUN
admet-36	8	42	and	and	CCONJ
admet-36	8	43	are	be	AUX
admet-36	8	44	linked	link	VERB
admet-36	8	45	to	to	ADP
admet-36	8	46	higher	high	ADJ
admet-36	8	47	cost	cost	NOUN
admet-36	8	48	in	in	ADP
admet-36	8	49	drug	drug	NOUN
admet-36	8	50	development	development	NOUN
admet-36	8	51	.	.	PUNCT
admet-36	9	1	solubility	solubility	NOUN
admet-36	9	2	issues	issue	NOUN
admet-36	9	3	have	have	AUX
admet-36	9	4	been	be	AUX
admet-36	9	5	associated	associate	VERB
admet-36	9	6	with	with	ADP
admet-36	9	7	several	several	ADJ
admet-36	9	8	factors	factor	NOUN
admet-36	9	9	,	,	PUNCT
admet-36	9	10	like	like	ADP
admet-36	9	11	increased	increase	VERB
admet-36	9	12	use	use	NOUN
admet-36	9	13	of	of	ADP
admet-36	9	14	highthroughput	highthroughput	ADJ
admet-36	9	15	screening	screening	NOUN
admet-36	9	16	procedures	procedure	NOUN
admet-36	9	17	and	and	CCONJ
admet-36	9	18	thus	thus	ADV
admet-36	9	19	the	the	DET
admet-36	9	20	tendency	tendency	NOUN
admet-36	9	21	to	to	ADP
admet-36	9	22	higher	high	ADJ
admet-36	9	23	lipophilicity	lipophilicity	NOUN
admet-36	9	24	and	and	CCONJ
admet-36	9	25	molecular	molecular	ADJ
admet-36	9	26	weight	weight	NOUN
admet-36	9	27	[	[	X
admet-36	9	28	1	1	NUM
admet-36	9	29	]	]	PUNCT
admet-36	9	30	.	.	PUNCT
admet-36	10	1	furthermore	furthermore	ADV
admet-36	10	2	,	,	PUNCT
admet-36	10	3	there	there	PRON
admet-36	10	4	is	be	VERB
admet-36	10	5	a	a	DET
admet-36	10	6	shift	shift	NOUN
admet-36	10	7	of	of	ADP
admet-36	10	8	therapeutic	therapeutic	ADJ
admet-36	10	9	targets	target	NOUN
admet-36	10	10	from	from	ADP
admet-36	10	11	g	g	NOUN
admet-36	10	12	-	-	PUNCT
admet-36	10	13	protein	protein	NOUN
admet-36	10	14	coupled	couple	VERB
admet-36	10	15	receptors	receptor	NOUN
admet-36	10	16	and	and	CCONJ
admet-36	10	17	enzymes	enzyme	NOUN
admet-36	10	18	to	to	ADP
admet-36	10	19	more	more	ADV
admet-36	10	20	challenging	challenging	ADJ
admet-36	10	21	ones	one	NOUN
admet-36	10	22	,	,	PUNCT
admet-36	10	23	such	such	ADJ
admet-36	10	24	as	as	ADP
admet-36	10	25	kinases	kinase	NOUN
admet-36	10	26	,	,	PUNCT
admet-36	10	27	ion	ion	NOUN
admet-36	10	28	channels	channel	NOUN
admet-36	10	29	,	,	PUNCT
admet-36	10	30	nuclear	nuclear	ADJ
admet-36	10	31	receptors	receptor	NOUN
admet-36	10	32	and	and	CCONJ
admet-36	10	33	protein	protein	NOUN
admet-36	10	34	-	-	PUNCT
admet-36	10	35	protein	protein	NOUN
admet-36	10	36	interactions	interaction	NOUN
admet-36	10	37	.	.	PUNCT
admet-36	11	1	for	for	ADP
admet-36	11	2	these	these	DET
admet-36	11	3	targets	target	NOUN
admet-36	11	4	,	,	PUNCT
admet-36	11	5	often	often	ADV
admet-36	11	6	a	a	DET
admet-36	11	7	higher	high	ADJ
admet-36	11	8	lipophilicity	lipophilicity	NOUN
admet-36	11	9	[	[	X
admet-36	11	10	2	2	NUM
admet-36	11	11	]	]	PUNCT
admet-36	11	12	or	or	CCONJ
admet-36	11	13	strong	strong	ADJ
admet-36	11	14	intermolecular	intermolecular	ADJ
admet-36	11	15	interactions	interaction	NOUN
admet-36	11	16	,	,	PUNCT
admet-36	11	17	such	such	ADJ
admet-36	11	18	as	as	ADP
admet-36	11	19	intermolecular	intermolecular	ADJ
admet-36	11	20	hydrogen	hydrogen	NOUN
admet-36	11	21	bonds	bond	NOUN
admet-36	11	22	,	,	PUNCT
admet-36	11	23	is	be	AUX
admet-36	11	24	required	require	VERB
admet-36	11	25	.	.	PUNCT
admet-36	12	1	both	both	DET
admet-36	12	2	lipophilicity	lipophilicity	NOUN
admet-36	12	3	and	and	CCONJ
admet-36	12	4	intermolecular	intermolecular	ADJ
admet-36	12	5	bonds	bond	NOUN
admet-36	12	6	tend	tend	VERB
admet-36	12	7	to	to	PART
admet-36	12	8	negatively	negatively	ADV
admet-36	12	9	affect	affect	VERB
admet-36	12	10	compound	compound	NOUN
admet-36	12	11	solubility	solubility	NOUN
admet-36	12	12	,	,	PUNCT
admet-36	12	13	and	and	CCONJ
admet-36	12	14	the	the	DET
admet-36	12	15	aim	aim	NOUN
admet-36	12	16	of	of	ADP
admet-36	12	17	this	this	DET
admet-36	12	18	work	work	NOUN
admet-36	12	19	is	be	AUX
admet-36	12	20	to	to	PART
admet-36	12	21	present	present	VERB
admet-36	12	22	a	a	DET
admet-36	12	23	way	way	NOUN
admet-36	12	24	to	to	PART
admet-36	12	25	distinguish	distinguish	VERB
admet-36	12	26	them	they	PRON
admet-36	12	27	using	use	VERB
admet-36	12	28	an	an	DET
admet-36	12	29	example	example	NOUN
admet-36	12	30	in	in	ADP
admet-36	12	31	which	which	PRON
admet-36	12	32	the	the	DET
admet-36	12	33	solid	solid	ADJ
admet-36	12	34	state	state	NOUN
admet-36	12	35	contribution	contribution	NOUN
admet-36	12	36	is	be	AUX
admet-36	12	37	impacted	impact	VERB
admet-36	12	38	by	by	ADP
admet-36	12	39	hydrate	hydrate	ADJ
admet-36	12	40	formation	formation	NOUN
admet-36	12	41	.	.	PUNCT
admet-36	13	1	in	in	ADP
admet-36	13	2	fact	fact	NOUN
admet-36	13	3	,	,	PUNCT
admet-36	13	4	solubility	solubility	NOUN
admet-36	13	5	still	still	ADV
admet-36	13	6	remains	remain	VERB
admet-36	13	7	one	one	NUM
admet-36	13	8	of	of	ADP
admet-36	13	9	the	the	DET
admet-36	13	10	key	key	ADJ
admet-36	13	11	challenges	challenge	NOUN
admet-36	13	12	in	in	ADP
admet-36	13	13	many	many	ADJ
admet-36	13	14	drug	drug	NOUN
admet-36	13	15	discovery	discovery	NOUN
admet-36	13	16	projects	project	NOUN
admet-36	13	17	.	.	PUNCT
admet-36	14	1	thus	thus	ADV
admet-36	14	2	,	,	PUNCT
admet-36	14	3	it	it	PRON
admet-36	14	4	is	be	AUX
admet-36	14	5	essential	essential	ADJ
admet-36	14	6	to	to	PART
admet-36	14	7	support	support	VERB
admet-36	14	8	the	the	DET
admet-36	14	9	lead	lead	NOUN
admet-36	14	10	finding	finding	NOUN
admet-36	14	11	and	and	CCONJ
admet-36	14	12	optimization	optimization	NOUN
admet-36	14	13	efforts	effort	NOUN
admet-36	14	14	with	with	ADP
admet-36	14	15	appropriate	appropriate	ADJ
admet-36	14	16	solubility	solubility	NOUN
admet-36	14	17	data	datum	NOUN
admet-36	14	18	.	.	PUNCT
admet-36	15	1	despite	despite	SCONJ
admet-36	15	2	advancement	advancement	NOUN
admet-36	15	3	in	in	ADP
admet-36	15	4	in	in	ADP
admet-36	15	5	silico	silico	NOUN
admet-36	15	6	solubility	solubility	NOUN
admet-36	15	7	prediction	prediction	NOUN
admet-36	15	8	,	,	PUNCT
admet-36	15	9	it	it	PRON
admet-36	15	10	remains	remain	VERB
admet-36	15	11	a	a	DET
admet-36	15	12	challenging	challenging	ADJ
admet-36	15	13	field	field	NOUN
admet-36	15	14	,	,	PUNCT
admet-36	15	15	mainly	mainly	ADV
admet-36	15	16	due	due	ADP
admet-36	15	17	to	to	ADP
admet-36	15	18	the	the	DET
admet-36	15	19	low	low	ADJ
admet-36	15	20	success	success	NOUN
admet-36	15	21	of	of	ADP
admet-36	15	22	prediction	prediction	NOUN
admet-36	15	23	of	of	ADP
admet-36	15	24	solid	solid	ADJ
admet-36	15	25	state	state	NOUN
admet-36	15	26	contribution	contribution	NOUN
admet-36	15	27	to	to	ADP
admet-36	15	28	the	the	DET
admet-36	15	29	thermodynamic	thermodynamic	ADJ
admet-36	15	30	solubility	solubility	NOUN
admet-36	15	31	of	of	ADP
admet-36	15	32	a	a	DET
admet-36	15	33	crystalline	crystalline	ADJ
admet-36	15	34	drug	drug	NOUN
admet-36	15	35	compound	compound	NOUN
admet-36	15	36	.	.	PUNCT
admet-36	16	1	as	as	ADP
admet-36	16	2	a	a	DET
admet-36	16	3	consequence	consequence	NOUN
admet-36	16	4	,	,	PUNCT
admet-36	16	5	a	a	DET
admet-36	16	6	screening	screening	NOUN
admet-36	16	7	assay	assay	NOUN
admet-36	16	8	is	be	AUX
admet-36	16	9	used	use	VERB
admet-36	16	10	as	as	ADP
admet-36	16	11	a	a	DET
admet-36	16	12	first	first	ADJ
admet-36	16	13	filter	filter	NOUN
admet-36	16	14	in	in	ADP
admet-36	16	15	a	a	DET
admet-36	16	16	modern	modern	ADJ
admet-36	16	17	drug	drug	NOUN
admet-36	16	18	discovery	discovery	NOUN
admet-36	16	19	environment	environment	NOUN
admet-36	16	20	,	,	PUNCT
admet-36	16	21	followed	follow	VERB
admet-36	16	22	by	by	ADP
admet-36	16	23	selected	select	VERB
admet-36	16	24	follow	follow	NOUN
admet-36	16	25	-	-	PUNCT
admet-36	16	26	up	up	NOUN
admet-36	16	27	assays	assay	NOUN
admet-36	16	28	to	to	PART
admet-36	16	29	reveal	reveal	VERB
admet-36	16	30	what	what	PRON
admet-36	16	31	causes	cause	VERB
admet-36	16	32	the	the	DET
admet-36	16	33	low	low	ADJ
admet-36	16	34	solubility	solubility	NOUN
admet-36	16	35	of	of	ADP
admet-36	16	36	a	a	DET
admet-36	16	37	specific	specific	ADJ
admet-36	16	38	compound	compound	NOUN
admet-36	16	39	or	or	CCONJ
admet-36	16	40	chemotype	chemotype	NOUN
admet-36	16	41	.	.	PUNCT
admet-36	17	1	solubility	solubility	NOUN
admet-36	17	2	high	high	ADJ
admet-36	17	3	-	-	PUNCT
admet-36	17	4	throughput	throughput	NOUN
admet-36	17	5	screening	screening	NOUN
admet-36	17	6	assays	assay	NOUN
admet-36	17	7	typically	typically	ADV
admet-36	17	8	allow	allow	VERB
admet-36	17	9	the	the	DET
admet-36	17	10	determination	determination	NOUN
admet-36	17	11	of	of	ADP
admet-36	17	12	solubility	solubility	NOUN
admet-36	17	13	with	with	ADP
admet-36	17	14	a	a	DET
admet-36	17	15	reasonable	reasonable	ADJ
admet-36	17	16	experimental	experimental	ADJ
admet-36	17	17	error	error	NOUN
admet-36	17	18	and	and	CCONJ
admet-36	17	19	within	within	ADP
admet-36	17	20	short	short	ADJ
admet-36	17	21	turn	turn	NOUN
admet-36	17	22	-	-	PUNCT
admet-36	17	23	around	around	ADP
admet-36	17	24	time	time	NOUN
admet-36	17	25	.	.	PUNCT
admet-36	18	1	their	their	PRON
admet-36	18	2	main	main	ADJ
admet-36	18	3	drawback	drawback	NOUN
admet-36	18	4	is	be	AUX
admet-36	18	5	that	that	SCONJ
admet-36	18	6	the	the	DET
admet-36	18	7	solidhttp://www.pub.iapchem.org/ojs/index.php/admet/index	solidhttp://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-36	18	8	mailto:joerg.berghausen@novartis.com	mailto:joerg.berghausen@novartis.com	X
admet-36	18	9	berghausen	berghausen	NOUN
admet-36	18	10	and	and	CCONJ
admet-36	18	11	faller	faller	NOUN
admet-36	18	12	admet	admet	PROPN
admet-36	18	13	&	&	CCONJ
admet-36	18	14	dmpk	dmpk	PROPN
admet-36	18	15	2(2	2(2	NUM
admet-36	18	16	)	)	PUNCT
admet-36	18	17	(	(	PUNCT
admet-36	18	18	2014	2014	NUM
admet-36	18	19	)	)	PUNCT
admet-36	18	20	115	115	NUM
admet-36	18	21	-	-	SYM
admet-36	18	22	125	125	NUM
admet-36	18	23	116	116	NUM
admet-36	18	24	state	state	NOUN
admet-36	18	25	of	of	ADP
admet-36	18	26	the	the	DET
admet-36	18	27	investigated	investigate	VERB
admet-36	18	28	compounds	compound	NOUN
admet-36	18	29	is	be	AUX
admet-36	18	30	either	either	CCONJ
admet-36	18	31	not	not	PART
admet-36	18	32	characterized	characterize	VERB
admet-36	18	33	at	at	ADV
admet-36	18	34	all	all	ADV
admet-36	18	35	or	or	CCONJ
admet-36	18	36	at	at	ADP
admet-36	18	37	best	good	ADJ
admet-36	18	38	by	by	ADP
admet-36	18	39	methods	method	NOUN
admet-36	18	40	that	that	PRON
admet-36	18	41	allow	allow	VERB
admet-36	18	42	a	a	DET
admet-36	18	43	qualitative	qualitative	ADJ
admet-36	18	44	assessment	assessment	NOUN
admet-36	18	45	only	only	ADV
admet-36	18	46	,	,	PUNCT
admet-36	18	47	like	like	ADP
admet-36	18	48	e.g.	e.g.	ADV
admet-36	18	49	birefringence	birefringence	NOUN
admet-36	18	50	or	or	CCONJ
admet-36	18	51	polarized	polarize	VERB
admet-36	18	52	microscopy	microscopy	NOUN
admet-36	18	53	[	[	X
admet-36	18	54	3	3	NUM
admet-36	18	55	]	]	PUNCT
admet-36	18	56	.	.	PUNCT
admet-36	19	1	such	such	ADJ
admet-36	19	2	high	high	ADJ
admet-36	19	3	-	-	PUNCT
admet-36	19	4	throughput	throughput	NOUN
admet-36	19	5	solubility	solubility	NOUN
admet-36	19	6	data	datum	NOUN
admet-36	19	7	allows	allow	VERB
admet-36	19	8	tracking	track	VERB
admet-36	19	9	the	the	DET
admet-36	19	10	development	development	NOUN
admet-36	19	11	of	of	ADP
admet-36	19	12	a	a	DET
admet-36	19	13	chemical	chemical	NOUN
admet-36	19	14	series	series	NOUN
admet-36	19	15	,	,	PUNCT
admet-36	19	16	e	e	PROPN
admet-36	19	17	.g	.g	PROPN
admet-36	19	18	.	.	PUNCT
admet-36	20	1	by	by	ADP
admet-36	20	2	creation	creation	NOUN
admet-36	20	3	of	of	ADP
admet-36	20	4	qsar	qsar	NOUN
admet-36	20	5	models	model	NOUN
admet-36	20	6	[	[	X
admet-36	20	7	4	4	NUM
admet-36	20	8	]	]	PUNCT
admet-36	20	9	.	.	PUNCT
admet-36	21	1	nevertheless	nevertheless	ADV
admet-36	21	2	,	,	PUNCT
admet-36	21	3	to	to	PART
admet-36	21	4	overcome	overcome	VERB
admet-36	21	5	solubility	solubility	NOUN
admet-36	21	6	issues	issue	NOUN
admet-36	21	7	beyond	beyond	ADP
admet-36	21	8	lipophilicity	lipophilicity	NOUN
admet-36	21	9	,	,	PUNCT
admet-36	21	10	guidance	guidance	NOUN
admet-36	21	11	for	for	ADP
admet-36	21	12	the	the	DET
admet-36	21	13	chemistry	chemistry	NOUN
admet-36	21	14	teams	team	NOUN
admet-36	21	15	on	on	ADP
admet-36	21	16	what	what	PRON
admet-36	21	17	is	be	AUX
admet-36	21	18	the	the	DET
admet-36	21	19	root	root	NOUN
admet-36	21	20	cause	cause	NOUN
admet-36	21	21	of	of	ADP
admet-36	21	22	solubility	solubility	NOUN
admet-36	21	23	limitation	limitation	NOUN
admet-36	21	24	is	be	AUX
admet-36	21	25	inevitable	inevitable	ADJ
admet-36	21	26	.	.	PUNCT
admet-36	22	1	for	for	ADP
admet-36	22	2	that	that	PRON
admet-36	22	3	,	,	PUNCT
admet-36	22	4	secondary	secondary	ADJ
admet-36	22	5	assays	assay	NOUN
admet-36	22	6	need	need	VERB
admet-36	22	7	to	to	PART
admet-36	22	8	be	be	AUX
admet-36	22	9	applied	apply	VERB
admet-36	22	10	that	that	PRON
admet-36	22	11	allow	allow	VERB
admet-36	22	12	conclusions	conclusion	NOUN
admet-36	22	13	to	to	PART
admet-36	22	14	be	be	AUX
admet-36	22	15	drawn	draw	VERB
admet-36	22	16	on	on	ADP
admet-36	22	17	the	the	DET
admet-36	22	18	interplay	interplay	NOUN
admet-36	22	19	of	of	ADP
admet-36	22	20	the	the	DET
admet-36	22	21	main	main	ADJ
admet-36	22	22	solubility	solubility	NOUN
admet-36	22	23	limiting	limit	VERB
admet-36	22	24	factors	factor	NOUN
admet-36	22	25	.	.	PUNCT
admet-36	23	1	for	for	ADP
admet-36	23	2	most	most	ADJ
admet-36	23	3	of	of	ADP
admet-36	23	4	the	the	DET
admet-36	23	5	compounds	compound	NOUN
admet-36	23	6	in	in	ADP
admet-36	23	7	the	the	DET
admet-36	23	8	chemical	chemical	NOUN
admet-36	23	9	space	space	NOUN
admet-36	23	10	of	of	ADP
admet-36	23	11	low	low	ADJ
admet-36	23	12	molecular	molecular	ADJ
admet-36	23	13	weight	weight	NOUN
admet-36	23	14	drug	drug	NOUN
admet-36	23	15	candidates	candidate	NOUN
admet-36	23	16	these	these	DET
admet-36	23	17	factors	factor	NOUN
admet-36	23	18	comprise	comprise	VERB
admet-36	23	19	lipophilicity	lipophilicity	NOUN
admet-36	23	20	,	,	PUNCT
admet-36	23	21	crystal	crystal	NOUN
admet-36	23	22	lattice	lattice	PROPN
admet-36	23	23	forces	force	NOUN
admet-36	23	24	and	and	CCONJ
admet-36	23	25	ionization	ionization	NOUN
admet-36	23	26	.	.	PUNCT
admet-36	24	1	in	in	ADP
admet-36	24	2	addition	addition	NOUN
admet-36	24	3	,	,	PUNCT
admet-36	24	4	other	other	ADJ
admet-36	24	5	factors	factor	NOUN
admet-36	24	6	like	like	ADP
admet-36	24	7	common	common	ADJ
admet-36	24	8	ion	ion	NOUN
admet-36	24	9	effect	effect	NOUN
admet-36	24	10	and	and	CCONJ
admet-36	24	11	compound	compound	NOUN
admet-36	24	12	aggregation	aggregation	NOUN
admet-36	24	13	in	in	ADP
admet-36	24	14	solution	solution	NOUN
admet-36	24	15	may	may	AUX
admet-36	24	16	further	far	ADV
admet-36	24	17	limit	limit	VERB
admet-36	24	18	the	the	DET
admet-36	24	19	solubility	solubility	NOUN
admet-36	24	20	of	of	ADP
admet-36	24	21	a	a	DET
admet-36	24	22	molecule	molecule	NOUN
admet-36	24	23	.	.	PUNCT
admet-36	25	1	as	as	ADP
admet-36	25	2	a	a	DET
admet-36	25	3	drawback	drawback	NOUN
admet-36	25	4	,	,	PUNCT
admet-36	25	5	these	these	DET
admet-36	25	6	investigations	investigation	NOUN
admet-36	25	7	require	require	VERB
admet-36	25	8	the	the	DET
admet-36	25	9	availability	availability	NOUN
admet-36	25	10	of	of	ADP
admet-36	25	11	about	about	ADV
admet-36	25	12	20	20	NUM
admet-36	25	13	mg	mg	NOUN
admet-36	25	14	of	of	ADP
admet-36	25	15	crystalline	crystalline	NOUN
admet-36	25	16	material	material	NOUN
admet-36	25	17	and	and	CCONJ
admet-36	25	18	are	be	AUX
admet-36	25	19	carried	carry	VERB
admet-36	25	20	out	out	ADP
admet-36	25	21	at	at	ADP
admet-36	25	22	medium	medium	ADJ
admet-36	25	23	throughput	throughput	NOUN
admet-36	25	24	.	.	PUNCT
admet-36	26	1	consequently	consequently	ADV
admet-36	26	2	,	,	PUNCT
admet-36	26	3	this	this	DET
admet-36	26	4	kind	kind	NOUN
admet-36	26	5	of	of	ADP
admet-36	26	6	solubility	solubility	NOUN
admet-36	26	7	diagnosis	diagnosis	NOUN
admet-36	26	8	can	can	AUX
admet-36	26	9	be	be	AUX
admet-36	26	10	performed	perform	VERB
admet-36	26	11	on	on	ADP
admet-36	26	12	selected	select	VERB
admet-36	26	13	molecules	molecule	NOUN
admet-36	26	14	only	only	ADV
admet-36	26	15	.	.	PUNCT
admet-36	27	1	nevertheless	nevertheless	ADV
admet-36	27	2	,	,	PUNCT
admet-36	27	3	when	when	SCONJ
admet-36	27	4	performed	perform	VERB
admet-36	27	5	early	early	ADV
admet-36	27	6	enough	enough	ADV
admet-36	27	7	during	during	ADP
admet-36	27	8	lead	lead	ADJ
admet-36	27	9	optimization	optimization	NOUN
admet-36	27	10	,	,	PUNCT
admet-36	27	11	solubility	solubility	NOUN
admet-36	27	12	issues	issue	NOUN
admet-36	27	13	of	of	ADP
admet-36	27	14	a	a	DET
admet-36	27	15	chemical	chemical	NOUN
admet-36	27	16	series	series	NOUN
admet-36	27	17	can	can	AUX
admet-36	27	18	be	be	AUX
admet-36	27	19	revealed	reveal	VERB
admet-36	27	20	and	and	CCONJ
admet-36	27	21	the	the	DET
admet-36	27	22	knowledge	knowledge	NOUN
admet-36	27	23	acquired	acquire	VERB
admet-36	27	24	can	can	AUX
admet-36	27	25	be	be	AUX
admet-36	27	26	applied	apply	VERB
admet-36	27	27	to	to	ADP
admet-36	27	28	the	the	DET
admet-36	27	29	optimization	optimization	NOUN
admet-36	27	30	strategy	strategy	NOUN
admet-36	27	31	.	.	PUNCT
admet-36	28	1	acceleration	acceleration	NOUN
admet-36	28	2	of	of	ADP
admet-36	28	3	solubility	solubility	NOUN
admet-36	28	4	diagnosis	diagnosis	NOUN
admet-36	28	5	could	could	AUX
admet-36	28	6	rather	rather	ADV
admet-36	28	7	profit	profit	VERB
admet-36	28	8	from	from	ADP
admet-36	28	9	advancements	advancement	NOUN
admet-36	28	10	in	in	ADP
admet-36	28	11	in	in	ADP
admet-36	28	12	silico	silico	NOUN
admet-36	28	13	prediction	prediction	NOUN
admet-36	28	14	of	of	ADP
admet-36	28	15	properties	property	NOUN
admet-36	28	16	that	that	PRON
admet-36	28	17	are	be	AUX
admet-36	28	18	currently	currently	ADV
admet-36	28	19	not	not	PART
admet-36	28	20	accessible	accessible	ADJ
admet-36	28	21	at	at	ADP
admet-36	28	22	the	the	DET
admet-36	28	23	desired	desire	VERB
admet-36	28	24	level	level	NOUN
admet-36	28	25	of	of	ADP
admet-36	28	26	quality	quality	NOUN
admet-36	28	27	.	.	PUNCT
admet-36	29	1	these	these	PRON
admet-36	29	2	include	include	VERB
admet-36	29	3	the	the	DET
admet-36	29	4	melting	melting	NOUN
admet-36	29	5	point	point	NOUN
admet-36	29	6	and	and	CCONJ
admet-36	29	7	enthalpy	enthalpy	NOUN
admet-36	29	8	of	of	ADP
admet-36	29	9	fusion	fusion	NOUN
admet-36	29	10	as	as	ADP
admet-36	29	11	a	a	DET
admet-36	29	12	surrogate	surrogate	NOUN
admet-36	29	13	for	for	ADP
admet-36	29	14	crystal	crystal	PROPN
admet-36	29	15	lattice	lattice	PROPN
admet-36	29	16	energy	energy	NOUN
admet-36	29	17	,	,	PUNCT
admet-36	29	18	as	as	ADV
admet-36	29	19	well	well	ADV
admet-36	29	20	as	as	ADP
admet-36	29	21	the	the	DET
admet-36	29	22	lipophilicity	lipophilicity	NOUN
admet-36	29	23	.	.	PUNCT
admet-36	30	1	although	although	SCONJ
admet-36	30	2	prediction	prediction	NOUN
admet-36	30	3	of	of	ADP
admet-36	30	4	lipophilicity	lipophilicity	NOUN
admet-36	30	5	is	be	AUX
admet-36	30	6	broadly	broadly	ADV
admet-36	30	7	used	use	VERB
admet-36	30	8	with	with	ADP
admet-36	30	9	sufficient	sufficient	ADJ
admet-36	30	10	accuracy	accuracy	NOUN
admet-36	30	11	in	in	ADP
admet-36	30	12	general	general	ADJ
admet-36	30	13	chemical	chemical	NOUN
admet-36	30	14	space	space	NOUN
admet-36	30	15	,	,	PUNCT
admet-36	30	16	the	the	DET
admet-36	30	17	applicability	applicability	NOUN
admet-36	30	18	of	of	ADP
admet-36	30	19	the	the	DET
admet-36	30	20	selected	select	VERB
admet-36	30	21	prediction	prediction	NOUN
admet-36	30	22	tool	tool	NOUN
admet-36	30	23	for	for	ADP
admet-36	30	24	a	a	DET
admet-36	30	25	specific	specific	ADJ
admet-36	30	26	chemical	chemical	NOUN
admet-36	30	27	series	series	NOUN
admet-36	30	28	needs	need	VERB
admet-36	30	29	to	to	PART
admet-36	30	30	be	be	AUX
admet-36	30	31	confirmed	confirm	VERB
admet-36	30	32	by	by	ADP
admet-36	30	33	high	high	ADJ
admet-36	30	34	quality	quality	NOUN
admet-36	30	35	measurements	measurement	NOUN
admet-36	30	36	.	.	PUNCT
admet-36	31	1	prediction	prediction	NOUN
admet-36	31	2	of	of	ADP
admet-36	31	3	melting	melting	NOUN
admet-36	31	4	point	point	NOUN
admet-36	31	5	and	and	CCONJ
admet-36	31	6	lattice	lattice	NOUN
admet-36	31	7	energy	energy	NOUN
admet-36	31	8	is	be	AUX
admet-36	31	9	currently	currently	ADV
admet-36	31	10	not	not	PART
admet-36	31	11	available	available	ADJ
admet-36	31	12	at	at	ADP
admet-36	31	13	a	a	DET
admet-36	31	14	level	level	NOUN
admet-36	31	15	beyond	beyond	ADP
admet-36	31	16	classification	classification	NOUN
admet-36	31	17	(	(	PUNCT
admet-36	31	18	high	high	ADJ
admet-36	31	19	/	/	SYM
admet-36	31	20	intermediate	intermediate	ADJ
admet-36	31	21	/	/	SYM
admet-36	31	22	low	low	ADJ
admet-36	31	23	)	)	PUNCT
admet-36	32	1	[	[	X
admet-36	32	2	5	5	NUM
admet-36	32	3	]	]	PUNCT
admet-36	32	4	.	.	PUNCT
admet-36	33	1	additionally	additionally	ADV
admet-36	33	2	,	,	PUNCT
admet-36	33	3	it	it	PRON
admet-36	33	4	has	have	AUX
admet-36	33	5	been	be	AUX
admet-36	33	6	attempted	attempt	VERB
admet-36	33	7	to	to	PART
admet-36	33	8	express	express	VERB
admet-36	33	9	the	the	DET
admet-36	33	10	contribution	contribution	NOUN
admet-36	33	11	of	of	ADP
admet-36	33	12	crystal	crystal	NOUN
admet-36	33	13	lattice	lattice	NOUN
admet-36	33	14	by	by	ADP
admet-36	33	15	chemical	chemical	ADJ
admet-36	33	16	descriptors	descriptor	NOUN
admet-36	33	17	[	[	X
admet-36	33	18	6	6	NUM
admet-36	33	19	]	]	PUNCT
admet-36	33	20	;	;	PUNCT
admet-36	33	21	likewise	likewise	ADV
admet-36	33	22	improvements	improvement	NOUN
admet-36	33	23	to	to	ADP
admet-36	33	24	the	the	DET
admet-36	33	25	‘	'	PUNCT
admet-36	33	26	general	general	ADJ
admet-36	33	27	solubility	solubility	NOUN
admet-36	33	28	equation	equation	NOUN
admet-36	33	29	’	'	PUNCT
admet-36	33	30	(	(	PUNCT
admet-36	33	31	gse	gse	PROPN
admet-36	33	32	)	)	PUNCT
admet-36	33	33	by	by	ADP
admet-36	33	34	including	include	VERB
admet-36	33	35	the	the	DET
admet-36	33	36	psa	psa	NOUN
admet-36	33	37	have	have	AUX
admet-36	33	38	been	be	AUX
admet-36	33	39	reported	report	VERB
admet-36	33	40	[	[	X
admet-36	33	41	7	7	NUM
admet-36	33	42	]	]	PUNCT
admet-36	33	43	.	.	PUNCT
admet-36	34	1	in	in	ADP
admet-36	34	2	the	the	DET
admet-36	34	3	present	present	ADJ
admet-36	34	4	work	work	NOUN
admet-36	34	5	,	,	PUNCT
admet-36	34	6	the	the	DET
admet-36	34	7	procedure	procedure	NOUN
admet-36	34	8	to	to	PART
admet-36	34	9	reveal	reveal	VERB
admet-36	34	10	the	the	DET
admet-36	34	11	root	root	NOUN
admet-36	34	12	cause	cause	NOUN
admet-36	34	13	of	of	ADP
admet-36	34	14	solubility	solubility	NOUN
admet-36	34	15	limitation	limitation	NOUN
admet-36	34	16	is	be	AUX
admet-36	34	17	exemplified	exemplify	VERB
admet-36	34	18	by	by	ADP
admet-36	34	19	various	various	ADJ
admet-36	34	20	compounds	compound	NOUN
admet-36	34	21	,	,	PUNCT
admet-36	34	22	including	include	VERB
admet-36	34	23	some	some	PRON
admet-36	34	24	that	that	PRON
admet-36	34	25	are	be	AUX
admet-36	34	26	capable	capable	ADJ
admet-36	34	27	of	of	ADP
admet-36	34	28	forming	form	VERB
admet-36	34	29	hydrates	hydrate	NOUN
admet-36	34	30	.	.	PUNCT
admet-36	35	1	typically	typically	ADV
admet-36	35	2	,	,	PUNCT
admet-36	35	3	the	the	DET
admet-36	35	4	impact	impact	NOUN
admet-36	35	5	of	of	ADP
admet-36	35	6	the	the	DET
admet-36	35	7	solid	solid	ADJ
admet-36	35	8	state	state	NOUN
admet-36	35	9	on	on	ADP
admet-36	35	10	the	the	DET
admet-36	35	11	performance	performance	NOUN
admet-36	35	12	of	of	ADP
admet-36	35	13	a	a	DET
admet-36	35	14	chemical	chemical	NOUN
admet-36	35	15	entity	entity	NOUN
admet-36	35	16	as	as	ADP
admet-36	35	17	a	a	DET
admet-36	35	18	drug	drug	NOUN
admet-36	35	19	is	be	AUX
admet-36	35	20	investigated	investigate	VERB
admet-36	35	21	in	in	ADP
admet-36	35	22	the	the	DET
admet-36	35	23	early	early	ADJ
admet-36	35	24	development	development	NOUN
admet-36	35	25	phase	phase	NOUN
admet-36	35	26	in	in	ADP
admet-36	35	27	the	the	DET
admet-36	35	28	context	context	NOUN
admet-36	35	29	of	of	ADP
admet-36	35	30	clinical	clinical	ADJ
admet-36	35	31	formulation	formulation	NOUN
admet-36	35	32	development	development	NOUN
admet-36	35	33	,	,	PUNCT
admet-36	35	34	rather	rather	ADV
admet-36	35	35	than	than	ADP
admet-36	35	36	during	during	ADP
admet-36	35	37	lead	lead	ADJ
admet-36	35	38	optimization	optimization	NOUN
admet-36	35	39	.	.	PUNCT
admet-36	36	1	however	however	ADV
admet-36	36	2	,	,	PUNCT
admet-36	36	3	solid	solid	ADJ
admet-36	36	4	state	state	NOUN
admet-36	36	5	limitations	limitation	NOUN
admet-36	36	6	pose	pose	VERB
admet-36	36	7	a	a	DET
admet-36	36	8	risk	risk	NOUN
admet-36	36	9	that	that	PRON
admet-36	36	10	needs	need	VERB
admet-36	36	11	to	to	PART
admet-36	36	12	be	be	AUX
admet-36	36	13	identified	identify	VERB
admet-36	36	14	before	before	ADP
admet-36	36	15	compounds	compound	NOUN
admet-36	36	16	are	be	AUX
admet-36	36	17	selected	select	VERB
admet-36	36	18	for	for	ADP
admet-36	36	19	clinical	clinical	ADJ
admet-36	36	20	development	development	NOUN
admet-36	36	21	.	.	PUNCT
admet-36	37	1	as	as	ADP
admet-36	37	2	a	a	DET
admet-36	37	3	consequence	consequence	NOUN
admet-36	37	4	for	for	ADP
admet-36	37	5	oral	oral	ADJ
admet-36	37	6	administration	administration	NOUN
admet-36	37	7	,	,	PUNCT
admet-36	37	8	thermodynamic	thermodynamic	ADJ
admet-36	37	9	driving	drive	VERB
admet-36	37	10	forces	force	NOUN
admet-36	37	11	might	might	AUX
admet-36	37	12	limit	limit	VERB
admet-36	37	13	the	the	DET
admet-36	37	14	absorption	absorption	NOUN
admet-36	37	15	of	of	ADP
admet-36	37	16	a	a	DET
admet-36	37	17	compound	compound	NOUN
admet-36	37	18	in	in	ADP
admet-36	37	19	the	the	DET
admet-36	37	20	human	human	ADJ
admet-36	37	21	gastro	gastro	ADJ
admet-36	37	22	-	-	PUNCT
admet-36	37	23	intestinal	intestinal	ADJ
admet-36	37	24	tract	tract	NOUN
admet-36	37	25	,	,	PUNCT
admet-36	37	26	despite	despite	SCONJ
admet-36	37	27	any	any	DET
admet-36	37	28	formulation	formulation	NOUN
admet-36	37	29	efforts	effort	NOUN
admet-36	37	30	.	.	PUNCT
admet-36	38	1	experimental	experimental	ADJ
admet-36	38	2	solubility	solubility	NOUN
admet-36	38	3	assays	assay	VERB
admet-36	38	4	high	high	ADJ
admet-36	38	5	-	-	PUNCT
admet-36	38	6	throughput	throughput	NOUN
admet-36	38	7	equilibrium	equilibrium	NOUN
admet-36	38	8	solubility	solubility	NOUN
admet-36	38	9	sample	sample	NOUN
admet-36	38	10	preparation	preparation	NOUN
admet-36	38	11	for	for	ADP
admet-36	38	12	high	high	ADJ
admet-36	38	13	-	-	PUNCT
admet-36	38	14	throughput	throughput	NOUN
admet-36	38	15	equilibrium	equilibrium	NOUN
admet-36	38	16	solubility	solubility	NOUN
admet-36	38	17	determination	determination	NOUN
admet-36	38	18	is	be	AUX
admet-36	38	19	performed	perform	VERB
admet-36	38	20	in	in	ADP
admet-36	38	21	microtiter	microtiter	ADJ
admet-36	38	22	plate	plate	NOUN
admet-36	38	23	format	format	NOUN
admet-36	38	24	on	on	ADP
admet-36	38	25	an	an	DET
admet-36	38	26	automated	automate	VERB
admet-36	38	27	platform	platform	NOUN
admet-36	38	28	that	that	PRON
admet-36	38	29	is	be	AUX
admet-36	38	30	based	base	VERB
admet-36	38	31	on	on	ADP
admet-36	38	32	a	a	DET
admet-36	38	33	starplus	starplus	ADJ
admet-36	38	34	module	module	NOUN
admet-36	38	35	(	(	PUNCT
admet-36	38	36	hamilton	hamilton	PROPN
admet-36	38	37	)	)	PUNCT
admet-36	38	38	.	.	PUNCT
admet-36	39	1	in	in	ADP
admet-36	39	2	addition	addition	NOUN
admet-36	39	3	,	,	PUNCT
admet-36	39	4	the	the	DET
admet-36	39	5	platform	platform	NOUN
admet-36	39	6	comprises	comprise	VERB
admet-36	39	7	a	a	DET
admet-36	39	8	centrifuge	centrifuge	NOUN
admet-36	39	9	(	(	PUNCT
admet-36	39	10	rotanta	rotanta	NOUN
admet-36	39	11	,	,	PUNCT
admet-36	39	12	hettich	hettich	PROPN
admet-36	39	13	)	)	PUNCT
admet-36	39	14	,	,	PUNCT
admet-36	39	15	two	two	NUM
admet-36	39	16	plateshakers	plateshaker	NOUN
admet-36	39	17	(	(	PUNCT
admet-36	39	18	timix	timix	NOUN
admet-36	39	19	5	5	NUM
admet-36	39	20	,	,	PUNCT
admet-36	39	21	edmund	edmund	PROPN
admet-36	39	22	bühler	bühler	NOUN
admet-36	39	23	)	)	PUNCT
admet-36	39	24	,	,	PUNCT
admet-36	39	25	a	a	DET
admet-36	39	26	heat	heat	NOUN
admet-36	39	27	sealer	sealer	NOUN
admet-36	39	28	(	(	PUNCT
admet-36	39	29	alps-3000	alps-3000	ADJ
admet-36	39	30	,	,	PUNCT
admet-36	39	31	thermo	thermo	NOUN
admet-36	39	32	scientific	scientific	NOUN
admet-36	39	33	)	)	PUNCT
admet-36	39	34	as	as	ADV
admet-36	39	35	well	well	ADV
admet-36	39	36	as	as	ADP
admet-36	39	37	an	an	DET
admet-36	39	38	evaporator	evaporator	NOUN
admet-36	39	39	(	(	PUNCT
admet-36	39	40	combidancer	combidancer	NOUN
admet-36	39	41	,	,	PUNCT
admet-36	39	42	hettich	hettich	PROPN
admet-36	39	43	)	)	PUNCT
admet-36	39	44	.	.	PUNCT
admet-36	40	1	plates	plate	NOUN
admet-36	40	2	are	be	AUX
admet-36	40	3	handled	handle	VERB
admet-36	40	4	by	by	ADP
admet-36	40	5	a	a	DET
admet-36	40	6	robotic	robotic	ADJ
admet-36	40	7	arm	arm	NOUN
admet-36	40	8	(	(	PUNCT
admet-36	40	9	tx60	tx60	PROPN
admet-36	40	10	l	l	NOUN
admet-36	40	11	,	,	PUNCT
admet-36	40	12	stäubli	stäubli	VERB
admet-36	40	13	)	)	PUNCT
admet-36	40	14	that	that	PRON
admet-36	40	15	allows	allow	VERB
admet-36	40	16	the	the	DET
admet-36	40	17	transfer	transfer	NOUN
admet-36	40	18	between	between	ADP
admet-36	40	19	the	the	DET
admet-36	40	20	starplus	starplus	ADJ
admet-36	40	21	module	module	NOUN
admet-36	40	22	and	and	CCONJ
admet-36	40	23	the	the	DET
admet-36	40	24	various	various	ADJ
admet-36	40	25	instruments	instrument	NOUN
admet-36	40	26	.	.	PUNCT
admet-36	41	1	sample	sample	NOUN
admet-36	41	2	analysis	analysis	NOUN
admet-36	41	3	is	be	AUX
admet-36	41	4	performed	perform	VERB
admet-36	41	5	by	by	ADP
admet-36	41	6	mass	mass	ADJ
admet-36	41	7	spectrometry	spectrometry	NOUN
admet-36	41	8	using	use	VERB
admet-36	41	9	a	a	DET
admet-36	41	10	rapid	rapid	ADJ
admet-36	41	11	-	-	PUNCT
admet-36	41	12	fire	fire	NOUN
admet-36	41	13	-	-	PUNCT
admet-36	41	14	q	q	NOUN
admet-36	41	15	-	-	PUNCT
admet-36	41	16	tof	tof	PRON
admet-36	41	17	combination	combination	NOUN
admet-36	41	18	(	(	PUNCT
admet-36	41	19	agilent	agilent	PROPN
admet-36	41	20	)	)	PUNCT
admet-36	41	21	.	.	PUNCT
admet-36	42	1	results	result	NOUN
admet-36	42	2	are	be	AUX
admet-36	42	3	stored	store	VERB
admet-36	42	4	in	in	ADP
admet-36	42	5	a	a	DET
admet-36	42	6	proprietary	proprietary	ADJ
admet-36	42	7	laboratory	laboratory	NOUN
admet-36	42	8	information	information	NOUN
admet-36	42	9	system	system	NOUN
admet-36	42	10	and	and	CCONJ
admet-36	42	11	data	datum	NOUN
admet-36	42	12	evaluation	evaluation	NOUN
admet-36	42	13	is	be	AUX
admet-36	42	14	performed	perform	VERB
admet-36	42	15	by	by	ADP
admet-36	42	16	excel	excel	PROPN
admet-36	42	17	(	(	PUNCT
admet-36	42	18	microsoft	microsoft	PROPN
admet-36	42	19	)	)	PUNCT
admet-36	42	20	.	.	PUNCT
admet-36	43	1	admet	admet	PROPN
admet-36	43	2	&	&	CCONJ
admet-36	43	3	dmpk	dmpk	PROPN
admet-36	43	4	2(2	2(2	NUM
admet-36	43	5	)	)	PUNCT
admet-36	43	6	(	(	PUNCT
admet-36	43	7	2014	2014	NUM
admet-36	43	8	)	)	PUNCT
admet-36	43	9	115	115	NUM
admet-36	43	10	-	-	SYM
admet-36	43	11	125	125	NUM
admet-36	43	12	diagnosing	diagnosing	NOUN
admet-36	43	13	solubility	solubility	NOUN
admet-36	43	14	limitations	limitation	NOUN
admet-36	43	15	doi	doi	NOUN
admet-36	43	16	:	:	PUNCT
admet-36	43	17	10.5599	10.5599	NUM
admet-36	43	18	/	/	SYM
admet-36	43	19	admet.2.2.36	admet.2.2.36	NOUN
admet-36	43	20	117	117	NUM
admet-36	43	21	secondary	secondary	ADJ
admet-36	43	22	assays	assay	NOUN
admet-36	43	23	equilibrium	equilibrium	NOUN
admet-36	43	24	solubility	solubility	NOUN
admet-36	43	25	is	be	AUX
admet-36	43	26	determined	determine	VERB
admet-36	43	27	using	use	VERB
admet-36	43	28	the	the	DET
admet-36	43	29	shake	shake	NOUN
admet-36	43	30	-	-	PUNCT
admet-36	43	31	flask	flask	NOUN
admet-36	43	32	method	method	NOUN
admet-36	43	33	.	.	PUNCT
admet-36	44	1	about	about	ADV
admet-36	44	2	1.5	1.5	NUM
admet-36	44	3	mg	mg	NOUN
admet-36	44	4	of	of	ADP
admet-36	44	5	compound	compound	NOUN
admet-36	44	6	is	be	AUX
admet-36	44	7	put	put	VERB
admet-36	44	8	into	into	ADP
admet-36	44	9	a	a	DET
admet-36	44	10	vial	vial	ADJ
admet-36	44	11	and	and	CCONJ
admet-36	44	12	0.75	0.75	NUM
admet-36	44	13	ml	ml	NOUN
admet-36	44	14	of	of	ADP
admet-36	44	15	buffer	buffer	NOUN
admet-36	44	16	is	be	AUX
admet-36	44	17	added	add	VERB
admet-36	44	18	.	.	PUNCT
admet-36	45	1	the	the	DET
admet-36	45	2	mixture	mixture	NOUN
admet-36	45	3	is	be	AUX
admet-36	45	4	shaken	shake	VERB
admet-36	45	5	for	for	ADP
admet-36	45	6	20	20	NUM
admet-36	45	7	to	to	PART
admet-36	45	8	24	24	NUM
admet-36	45	9	hours	hour	NOUN
admet-36	45	10	and	and	CCONJ
admet-36	45	11	the	the	DET
admet-36	45	12	solid	solid	ADJ
admet-36	45	13	phase	phase	NOUN
admet-36	45	14	is	be	AUX
admet-36	45	15	separated	separate	VERB
admet-36	45	16	by	by	ADP
admet-36	45	17	centrifugation	centrifugation	NOUN
admet-36	45	18	.	.	PUNCT
admet-36	46	1	concentration	concentration	NOUN
admet-36	46	2	of	of	ADP
admet-36	46	3	the	the	DET
admet-36	46	4	compound	compound	NOUN
admet-36	46	5	in	in	ADP
admet-36	46	6	the	the	DET
admet-36	46	7	supernatant	supernatant	NOUN
admet-36	46	8	is	be	AUX
admet-36	46	9	determined	determine	VERB
admet-36	46	10	by	by	ADP
admet-36	46	11	hplc	hplc	PROPN
admet-36	46	12	-	-	PUNCT
admet-36	46	13	uv	uv	PROPN
admet-36	46	14	(	(	PUNCT
admet-36	46	15	agilent	agilent	PROPN
admet-36	46	16	1200	1200	NUM
admet-36	46	17	)	)	PUNCT
admet-36	46	18	based	base	VERB
admet-36	46	19	on	on	ADP
admet-36	46	20	a	a	DET
admet-36	46	21	calibration	calibration	NOUN
admet-36	46	22	curve	curve	NOUN
admet-36	46	23	.	.	PUNCT
admet-36	47	1	the	the	DET
admet-36	47	2	partition	partition	NOUN
admet-36	47	3	coefficient	coefficient	NOUN
admet-36	47	4	between	between	ADP
admet-36	47	5	aqueous	aqueous	ADJ
admet-36	47	6	phase	phase	NOUN
admet-36	47	7	and	and	CCONJ
admet-36	47	8	1	1	NUM
admet-36	47	9	-	-	PUNCT
admet-36	47	10	octanol	octanol	NOUN
admet-36	47	11	(	(	PUNCT
admet-36	47	12	log	log	NOUN
admet-36	47	13	d	d	NOUN
admet-36	47	14	)	)	PUNCT
admet-36	47	15	is	be	AUX
admet-36	47	16	determined	determine	VERB
admet-36	47	17	by	by	ADP
admet-36	47	18	various	various	ADJ
admet-36	47	19	methods	method	NOUN
admet-36	47	20	.	.	PUNCT
admet-36	48	1	ionizable	ionizable	ADJ
admet-36	48	2	compounds	compound	NOUN
admet-36	48	3	are	be	AUX
admet-36	48	4	analyzed	analyze	VERB
admet-36	48	5	by	by	ADP
admet-36	48	6	potentiometric	potentiometric	ADJ
admet-36	48	7	titration	titration	NOUN
admet-36	48	8	(	(	PUNCT
admet-36	48	9	sirius	sirius	PROPN
admet-36	48	10	t3	t3	PROPN
admet-36	48	11	,	,	PUNCT
admet-36	48	12	sirius	sirius	PROPN
admet-36	48	13	instruments	instruments	PROPN
admet-36	48	14	ltd	ltd	PROPN
admet-36	48	15	.	.	PROPN
admet-36	48	16	)	)	PUNCT
admet-36	48	17	.	.	PUNCT
admet-36	49	1	non	non	ADJ
admet-36	49	2	-	-	ADJ
admet-36	49	3	ionizable	ionizable	ADJ
admet-36	49	4	compounds	compound	NOUN
admet-36	49	5	are	be	AUX
admet-36	49	6	either	either	ADV
admet-36	49	7	analyzed	analyze	VERB
admet-36	49	8	by	by	ADP
admet-36	49	9	a	a	DET
admet-36	49	10	shake	shake	NOUN
admet-36	49	11	flask	flask	NOUN
admet-36	49	12	method	method	NOUN
admet-36	49	13	or	or	CCONJ
admet-36	49	14	by	by	ADP
admet-36	49	15	reverse	reverse	NOUN
admet-36	49	16	-	-	PUNCT
admet-36	49	17	hplc	hplc	NOUN
admet-36	49	18	(	(	PUNCT
admet-36	49	19	elogp	elogp	NOUN
admet-36	49	20	)	)	PUNCT
admet-36	50	1	[	[	X
admet-36	50	2	8	8	NUM
admet-36	50	3	]	]	PUNCT
admet-36	50	4	.	.	PUNCT
admet-36	51	1	determination	determination	NOUN
admet-36	51	2	of	of	ADP
admet-36	51	3	the	the	DET
admet-36	51	4	acid	acid	PROPN
admet-36	51	5	dissociation	dissociation	NOUN
admet-36	51	6	constant	constant	ADJ
admet-36	51	7	(	(	PUNCT
admet-36	51	8	pka	pka	NOUN
admet-36	51	9	)	)	PUNCT
admet-36	51	10	is	be	AUX
admet-36	51	11	also	also	ADV
admet-36	51	12	done	do	VERB
admet-36	51	13	by	by	ADP
admet-36	51	14	potentiometric	potentiometric	ADJ
admet-36	51	15	titration	titration	NOUN
admet-36	51	16	(	(	PUNCT
admet-36	51	17	sirius	sirius	PROPN
admet-36	51	18	t3	t3	PROPN
admet-36	51	19	,	,	PUNCT
admet-36	51	20	sirius	sirius	PROPN
admet-36	51	21	instruments	instruments	PROPN
admet-36	51	22	ltd	ltd	PROPN
admet-36	51	23	.	.	PROPN
admet-36	51	24	)	)	PUNCT
admet-36	51	25	.	.	PUNCT
admet-36	52	1	0.7	0.7	NUM
admet-36	52	2	-	-	SYM
admet-36	52	3	1.2	1.2	NUM
admet-36	52	4	mg	mg	NOUN
admet-36	52	5	of	of	ADP
admet-36	52	6	compound	compound	NOUN
admet-36	52	7	(	(	PUNCT
admet-36	52	8	final	final	ADJ
admet-36	52	9	concentration	concentration	NOUN
admet-36	52	10	1	1	NUM
admet-36	52	11	mm	mm	NOUN
admet-36	52	12	)	)	PUNCT
admet-36	52	13	is	be	AUX
admet-36	52	14	dissolved	dissolve	VERB
admet-36	52	15	in	in	ADP
admet-36	52	16	meoh	meoh	PROPN
admet-36	52	17	/	/	SYM
admet-36	52	18	h2o	h2o	PROPN
admet-36	52	19	(	(	PUNCT
admet-36	52	20	0.15	0.15	NUM
admet-36	52	21	m	m	NOUN
admet-36	52	22	kcl	kcl	NOUN
admet-36	52	23	)	)	PUNCT
admet-36	52	24	.	.	PUNCT
admet-36	53	1	titration	titration	NOUN
admet-36	53	2	is	be	AUX
admet-36	53	3	performed	perform	VERB
admet-36	53	4	in	in	ADP
admet-36	53	5	60/50/40	60/50/40	PROPN
admet-36	53	6	or	or	CCONJ
admet-36	53	7	40/30/20	40/30/20	NUM
admet-36	53	8	%	%	NOUN
admet-36	53	9	w	w	PROPN
admet-36	53	10	/	/	SYM
admet-36	53	11	v	v	NOUN
admet-36	53	12	meoh	meoh	NOUN
admet-36	53	13	depending	depend	VERB
admet-36	53	14	on	on	ADP
admet-36	53	15	the	the	DET
admet-36	53	16	solubility	solubility	NOUN
admet-36	53	17	.	.	PUNCT
admet-36	54	1	the	the	DET
admet-36	54	2	pka	pka	PROPN
admet-36	54	3	is	be	AUX
admet-36	54	4	extrapolated	extrapolate	VERB
admet-36	54	5	to	to	ADP
admet-36	54	6	0	0	NUM
admet-36	54	7	%	%	NOUN
admet-36	54	8	water	water	NOUN
admet-36	54	9	with	with	ADP
admet-36	54	10	the	the	DET
admet-36	54	11	yasuda	yasuda	NOUN
admet-36	54	12	-	-	PUNCT
admet-36	54	13	shedlovsky	shedlovsky	ADJ
admet-36	54	14	extrapolation	extrapolation	NOUN
admet-36	55	1	[	[	X
admet-36	55	2	9	9	NUM
admet-36	55	3	]	]	PUNCT
admet-36	55	4	.	.	PUNCT
admet-36	56	1	intrinsic	intrinsic	ADJ
admet-36	56	2	solubility	solubility	NOUN
admet-36	56	3	(	(	PUNCT
admet-36	56	4	i.e.	i.e.	X
admet-36	56	5	solubility	solubility	NOUN
admet-36	56	6	of	of	ADP
admet-36	56	7	the	the	DET
admet-36	56	8	neutral	neutral	ADJ
admet-36	56	9	species	specie	NOUN
admet-36	56	10	)	)	PUNCT
admet-36	56	11	is	be	AUX
admet-36	56	12	determined	determine	VERB
admet-36	56	13	by	by	ADP
admet-36	56	14	a	a	DET
admet-36	56	15	potentiometric	potentiometric	ADJ
admet-36	56	16	titration	titration	NOUN
admet-36	56	17	approach	approach	NOUN
admet-36	56	18	[	[	X
admet-36	56	19	10	10	NUM
admet-36	56	20	]	]	PUNCT
admet-36	56	21	.	.	PUNCT
admet-36	57	1	0.7	0.7	NUM
admet-36	57	2	-	-	SYM
admet-36	57	3	1.2	1.2	NUM
admet-36	57	4	mg	mg	NOUN
admet-36	57	5	of	of	ADP
admet-36	57	6	compound	compound	NOUN
admet-36	57	7	(	(	PUNCT
admet-36	57	8	final	final	ADJ
admet-36	57	9	concentration	concentration	NOUN
admet-36	57	10	1	1	NUM
admet-36	57	11	mm	mm	NOUN
admet-36	57	12	)	)	PUNCT
admet-36	57	13	is	be	AUX
admet-36	57	14	dissolved	dissolve	VERB
admet-36	57	15	in	in	ADP
admet-36	57	16	aqueous	aqueous	ADJ
admet-36	57	17	buffer	buffer	NOUN
admet-36	57	18	.	.	PUNCT
admet-36	58	1	the	the	DET
admet-36	58	2	intrinsic	intrinsic	ADJ
admet-36	58	3	solubility	solubility	NOUN
admet-36	58	4	is	be	AUX
admet-36	58	5	determined	determine	VERB
admet-36	58	6	by	by	ADP
admet-36	58	7	mathematical	mathematical	ADJ
admet-36	58	8	analysis	analysis	NOUN
admet-36	58	9	of	of	ADP
admet-36	58	10	the	the	DET
admet-36	58	11	titration	titration	NOUN
admet-36	58	12	curve	curve	NOUN
admet-36	58	13	based	base	VERB
admet-36	58	14	on	on	ADP
admet-36	58	15	measured	measure	VERB
admet-36	58	16	pka	pka	PROPN
admet-36	58	17	values	value	NOUN
admet-36	58	18	.	.	PUNCT
admet-36	59	1	ionization	ionization	NOUN
admet-36	59	2	species	specie	NOUN
admet-36	59	3	distribution	distribution	NOUN
admet-36	59	4	is	be	AUX
admet-36	59	5	calculated	calculate	VERB
admet-36	59	6	by	by	ADP
admet-36	59	7	the	the	DET
admet-36	59	8	henderson	henderson	PROPN
admet-36	59	9	–	–	PUNCT
admet-36	59	10	hasselbalch	hasselbalch	PROPN
admet-36	59	11	equation	equation	NOUN
admet-36	59	12	.	.	PUNCT
admet-36	60	1	polar	polar	ADJ
admet-36	60	2	surface	surface	NOUN
admet-36	60	3	area	area	NOUN
admet-36	60	4	(	(	PUNCT
admet-36	60	5	psa	psa	NOUN
admet-36	60	6	)	)	PUNCT
admet-36	60	7	is	be	AUX
admet-36	60	8	calculated	calculate	VERB
admet-36	60	9	by	by	ADP
admet-36	60	10	the	the	DET
admet-36	60	11	topological	topological	ADJ
admet-36	60	12	psa	psa	NOUN
admet-36	60	13	method	method	NOUN
admet-36	60	14	according	accord	VERB
admet-36	60	15	to	to	ADP
admet-36	60	16	ertl	ertl	PROPN
admet-36	60	17	et	et	PROPN
admet-36	60	18	al	al	PROPN
admet-36	60	19	.	.	PUNCT
admet-36	61	1	[	[	X
admet-36	61	2	11	11	NUM
admet-36	61	3	]	]	PUNCT
admet-36	61	4	.	.	PUNCT
admet-36	61	5	melting	melt	VERB
admet-36	61	6	point	point	NOUN
admet-36	61	7	and	and	CCONJ
admet-36	61	8	enthalpy	enthalpy	NOUN
admet-36	61	9	of	of	ADP
admet-36	61	10	fusion	fusion	NOUN
admet-36	61	11	are	be	AUX
admet-36	61	12	determined	determine	VERB
admet-36	61	13	by	by	ADP
admet-36	61	14	differential	differential	NOUN
admet-36	61	15	scanning	scanning	NOUN
admet-36	61	16	calorimetry	calorimetry	NOUN
admet-36	61	17	(	(	PUNCT
admet-36	61	18	dsc	dsc	NOUN
admet-36	61	19	)	)	PUNCT
admet-36	61	20	with	with	ADP
admet-36	61	21	a	a	DET
admet-36	61	22	dsc	dsc	NOUN
admet-36	61	23	q2000	q2000	PROPN
admet-36	61	24	(	(	PUNCT
admet-36	61	25	ta	ta	NOUN
admet-36	61	26	instruments	instrument	NOUN
admet-36	61	27	)	)	PUNCT
admet-36	61	28	.	.	PUNCT
admet-36	62	1	a	a	DET
admet-36	62	2	standard	standard	ADJ
admet-36	62	3	heating	heating	NOUN
admet-36	62	4	rate	rate	NOUN
admet-36	62	5	of	of	ADP
admet-36	62	6	10	10	NUM
admet-36	62	7	k	k	NOUN
admet-36	62	8	/	/	SYM
admet-36	62	9	min	min	NOUN
admet-36	62	10	was	be	AUX
admet-36	62	11	used	use	VERB
admet-36	62	12	.	.	PUNCT
admet-36	63	1	solubility	solubility	NOUN
admet-36	63	2	diagnosis	diagnosis	VERB
admet-36	63	3	the	the	DET
admet-36	63	4	solubility	solubility	NOUN
admet-36	63	5	diagnosis	diagnosis	NOUN
admet-36	63	6	tool	tool	NOUN
admet-36	63	7	is	be	AUX
admet-36	63	8	an	an	DET
admet-36	63	9	advancement	advancement	NOUN
admet-36	63	10	of	of	ADP
admet-36	63	11	the	the	DET
admet-36	63	12	analysis	analysis	NOUN
admet-36	63	13	published	publish	VERB
admet-36	63	14	by	by	ADP
admet-36	63	15	faller	faller	NOUN
admet-36	63	16	and	and	CCONJ
admet-36	63	17	ertl	ertl	PROPN
admet-36	64	1	[	[	X
admet-36	64	2	12	12	NUM
admet-36	64	3	]	]	PUNCT
admet-36	64	4	.	.	PUNCT
admet-36	65	1	the	the	DET
admet-36	65	2	relationship	relationship	NOUN
admet-36	65	3	between	between	ADP
admet-36	65	4	log	log	NOUN
admet-36	65	5	p	p	NOUN
admet-36	65	6	and	and	CCONJ
admet-36	65	7	log	log	VERB
admet-36	65	8	1	1	NUM
admet-36	65	9	/	/	SYM
admet-36	65	10	s0	s0	PROPN
admet-36	65	11	revealed	reveal	VERB
admet-36	65	12	that	that	SCONJ
admet-36	65	13	only	only	ADV
admet-36	65	14	a	a	DET
admet-36	65	15	minority	minority	NOUN
admet-36	65	16	of	of	ADP
admet-36	65	17	compounds	compound	NOUN
admet-36	65	18	show	show	VERB
admet-36	65	19	higher	high	ADJ
admet-36	65	20	solubility	solubility	NOUN
admet-36	65	21	than	than	SCONJ
admet-36	65	22	determined	determine	VERB
admet-36	65	23	by	by	ADP
admet-36	65	24	their	their	PRON
admet-36	65	25	lipophilicity	lipophilicity	NOUN
admet-36	65	26	.	.	PUNCT
admet-36	66	1	many	many	ADJ
admet-36	66	2	potential	potential	ADJ
admet-36	66	3	drug	drug	NOUN
admet-36	66	4	candidates	candidate	NOUN
admet-36	66	5	do	do	AUX
admet-36	66	6	not	not	PART
admet-36	66	7	fall	fall	VERB
admet-36	66	8	on	on	ADP
admet-36	66	9	the	the	DET
admet-36	66	10	unity	unity	NOUN
admet-36	66	11	line	line	NOUN
admet-36	66	12	between	between	ADP
admet-36	66	13	log	log	NOUN
admet-36	66	14	p	p	NOUN
admet-36	66	15	and	and	CCONJ
admet-36	66	16	log	log	VERB
admet-36	66	17	1	1	NUM
admet-36	66	18	/	/	SYM
admet-36	66	19	s0	s0	NOUN
admet-36	66	20	,	,	PUNCT
admet-36	66	21	but	but	CCONJ
admet-36	66	22	show	show	VERB
admet-36	66	23	rather	rather	ADV
admet-36	66	24	lower	low	ADJ
admet-36	66	25	solubility	solubility	NOUN
admet-36	66	26	than	than	SCONJ
admet-36	66	27	predicted	predict	VERB
admet-36	66	28	by	by	ADP
admet-36	66	29	log	log	PROPN
admet-36	66	30	p.	p.	NOUN
admet-36	66	31	therefore	therefore	ADV
admet-36	66	32	,	,	PUNCT
admet-36	66	33	the	the	DET
admet-36	66	34	authors	author	NOUN
admet-36	66	35	[	[	X
admet-36	66	36	12	12	NUM
admet-36	66	37	]	]	PUNCT
admet-36	66	38	introduced	introduce	VERB
admet-36	66	39	the	the	DET
admet-36	66	40	sl	sl	ADJ
admet-36	66	41	parameter	parameter	NOUN
admet-36	66	42	(	(	PUNCT
admet-36	66	43	eq	eq	NOUN
admet-36	66	44	.	.	PROPN
admet-36	66	45	1	1	NUM
admet-36	66	46	)	)	PUNCT
admet-36	66	47	as	as	ADP
admet-36	66	48	a	a	DET
admet-36	66	49	descriptor	descriptor	NOUN
admet-36	66	50	of	of	ADP
admet-36	66	51	additional	additional	ADJ
admet-36	66	52	interactions	interaction	NOUN
admet-36	66	53	that	that	PRON
admet-36	66	54	limit	limit	VERB
admet-36	66	55	solubility	solubility	PRON
admet-36	66	56	.	.	PUNCT
admet-36	67	1	(	(	PUNCT
admet-36	67	2	1	1	X
admet-36	67	3	)	)	PUNCT
admet-36	67	4	in	in	ADP
admet-36	67	5	order	order	NOUN
admet-36	67	6	to	to	PART
admet-36	67	7	quantify	quantify	VERB
admet-36	67	8	the	the	DET
admet-36	67	9	contribution	contribution	NOUN
admet-36	67	10	of	of	ADP
admet-36	67	11	the	the	DET
admet-36	67	12	various	various	ADJ
admet-36	67	13	factors	factor	NOUN
admet-36	67	14	that	that	PRON
admet-36	67	15	contribute	contribute	VERB
admet-36	67	16	to	to	ADP
admet-36	67	17	solubility	solubility	NOUN
admet-36	67	18	limitation	limitation	NOUN
admet-36	67	19	,	,	PUNCT
admet-36	67	20	a	a	DET
admet-36	67	21	table	table	NOUN
admet-36	67	22	has	have	AUX
admet-36	67	23	been	be	AUX
admet-36	67	24	created	create	VERB
admet-36	67	25	that	that	SCONJ
admet-36	67	26	summarizes	summarize	VERB
admet-36	67	27	the	the	DET
admet-36	67	28	solubility	solubility	NOUN
admet-36	67	29	in	in	ADP
admet-36	67	30	the	the	DET
admet-36	67	31	relevant	relevant	ADJ
admet-36	67	32	buffer	buffer	NOUN
admet-36	67	33	medium	medium	NOUN
admet-36	67	34	,	,	PUNCT
admet-36	67	35	ionization	ionization	NOUN
admet-36	67	36	effects	effect	NOUN
admet-36	67	37	,	,	PUNCT
admet-36	67	38	the	the	DET
admet-36	67	39	solute	solute	NOUN
admet-36	67	40	-	-	PUNCT
admet-36	67	41	solvent	solvent	ADJ
admet-36	67	42	interactions	interaction	NOUN
admet-36	67	43	as	as	ADV
admet-36	67	44	well	well	ADV
admet-36	67	45	as	as	ADP
admet-36	67	46	crystal	crystal	PROPN
admet-36	67	47	lattice	lattice	PROPN
admet-36	67	48	energy	energy	NOUN
admet-36	67	49	contributions	contribution	NOUN
admet-36	67	50	(	(	PUNCT
admet-36	67	51	see	see	VERB
admet-36	67	52	table	table	NOUN
admet-36	67	53	1	1	NUM
admet-36	67	54	)	)	PUNCT
admet-36	67	55	.	.	PUNCT
admet-36	68	1	table	table	NOUN
admet-36	68	2	1	1	NUM
admet-36	68	3	.	.	PUNCT
admet-36	69	1	parameters	parameter	NOUN
admet-36	69	2	generated	generate	VERB
admet-36	69	3	for	for	ADP
admet-36	69	4	solubility	solubility	NOUN
admet-36	69	5	diagnosis	diagnosis	NOUN
admet-36	69	6	a	a	DET
admet-36	69	7	b	b	NOUN
admet-36	69	8	c	c	NOUN
admet-36	69	9	d	d	X
admet-36	69	10	e	e	X
admet-36	69	11	f	f	PROPN
admet-36	69	12	g	g	PROPN
admet-36	69	13	h	h	NOUN
admet-36	70	1	i	i	PRON
admet-36	70	2	log	log	VERB
admet-36	70	3	1	1	NUM
admet-36	70	4	/	/	SYM
admet-36	70	5	s6.8	s6.8	NOUN
admet-36	70	6	(	(	PUNCT
admet-36	70	7	measured	measure	VERB
admet-36	70	8	)	)	PUNCT
admet-36	70	9	log	log	VERB
admet-36	70	10	1	1	NUM
admet-36	70	11	/	/	SYM
admet-36	70	12	s6.8	s6.8	NOUN
admet-36	70	13	(	(	PUNCT
admet-36	70	14	extrapolated	extrapolated	ADJ
admet-36	70	15	)	)	PUNCT
admet-36	70	16	log	log	VERB
admet-36	70	17	1	1	NUM
admet-36	70	18	/	/	SYM
admet-36	70	19	s0	s0	X
admet-36	70	20	ip6.8	ip6.8	ADP
admet-36	70	21	elogp	elogp	NOUN
admet-36	70	22	sl	sl	NOUN
admet-36	70	23	tm	tm	PROPN
admet-36	70	24	hf	hf	NOUN
admet-36	70	25	,	,	PUNCT
admet-36	70	26	m	m	VERB
admet-36	70	27	cf	cf	VERB
admet-36	70	28	the	the	DET
admet-36	70	29	solubility	solubility	NOUN
admet-36	70	30	diagnosis	diagnosis	NOUN
admet-36	70	31	mainly	mainly	ADV
admet-36	70	32	helps	help	VERB
admet-36	70	33	to	to	PART
admet-36	70	34	compare	compare	VERB
admet-36	70	35	different	different	ADJ
admet-36	70	36	factors	factor	NOUN
admet-36	70	37	that	that	PRON
admet-36	70	38	contribute	contribute	VERB
admet-36	70	39	to	to	ADP
admet-36	70	40	solubility	solubility	NOUN
admet-36	70	41	limitation	limitation	NOUN
admet-36	70	42	.	.	PUNCT
admet-36	71	1	column	column	NOUN
admet-36	71	2	a	a	DET
admet-36	71	3	and	and	CCONJ
admet-36	71	4	b	b	NOUN
admet-36	71	5	in	in	ADP
admet-36	71	6	table	table	NOUN
admet-36	71	7	1	1	NUM
admet-36	71	8	compare	compare	VERB
admet-36	71	9	the	the	DET
admet-36	71	10	measured	measured	ADJ
admet-36	71	11	solubility	solubility	NOUN
admet-36	71	12	at	at	ADP
admet-36	71	13	ph	ph	PROPN
admet-36	71	14	6.8	6.8	NUM
admet-36	71	15	to	to	ADP
admet-36	71	16	the	the	DET
admet-36	71	17	extrapolated	extrapolated	ADJ
admet-36	71	18	solubility	solubility	NOUN
admet-36	71	19	value	value	NOUN
admet-36	71	20	,	,	PUNCT
admet-36	71	21	based	base	VERB
admet-36	71	22	on	on	ADP
admet-36	71	23	intrinsic	intrinsic	ADJ
admet-36	71	24	solubility	solubility	NOUN
admet-36	71	25	(	(	PUNCT
admet-36	71	26	column	column	NOUN
admet-36	71	27	c	c	NOUN
admet-36	71	28	)	)	PUNCT
admet-36	71	29	and	and	CCONJ
admet-36	71	30	the	the	DET
admet-36	71	31	compound	compound	NOUN
admet-36	71	32	’s	’s	PART
admet-36	71	33	ionization	ionization	NOUN
admet-36	71	34	state	state	NOUN
admet-36	71	35	.	.	PUNCT
admet-36	72	1	column	column	PROPN
admet-36	72	2	d	d	PROPN
admet-36	72	3	contains	contain	VERB
admet-36	72	4	the	the	DET
admet-36	72	5	ionization	ionization	NOUN
admet-36	72	6	parameter	parameter	NOUN
admet-36	72	7	,	,	PUNCT
admet-36	72	8	which	which	PRON
admet-36	72	9	is	be	AUX
admet-36	72	10	a	a	DET
admet-36	72	11	logarithmic	logarithmic	ADJ
admet-36	72	12	parameter	parameter	NOUN
admet-36	72	13	derived	derive	VERB
admet-36	72	14	from	from	ADP
admet-36	72	15	the	the	DET
admet-36	72	16	ionized	ionized	ADJ
admet-36	72	17	fraction	fraction	NOUN
admet-36	72	18	.	.	PUNCT
admet-36	73	1	the	the	DET
admet-36	73	2	latter	latter	ADJ
admet-36	73	3	,	,	PUNCT
admet-36	73	4	in	in	ADP
admet-36	73	5	turn	turn	NOUN
admet-36	73	6	,	,	PUNCT
admet-36	73	7	is	be	AUX
admet-36	73	8	calculated	calculate	VERB
admet-36	73	9	taking	take	VERB
admet-36	73	10	into	into	ADP
admet-36	73	11	account	account	NOUN
admet-36	73	12	the	the	DET
admet-36	73	13	compound	compound	NOUN
admet-36	73	14	formula	formula	NOUN
admet-36	73	15	(	(	PUNCT
admet-36	73	16	column	column	NOUN
admet-36	73	17	i	i	PROPN
admet-36	73	18	)	)	PUNCT
admet-36	73	19	.	.	PUNCT
admet-36	74	1	the	the	DET
admet-36	74	2	sl	sl	ADJ
admet-36	74	3	parameter	parameter	NOUN
admet-36	74	4	in	in	ADP
admet-36	74	5	column	column	PROPN
admet-36	74	6	f	f	PROPN
admet-36	74	7	,	,	PUNCT
admet-36	74	8	berghausen	berghausen	NOUN
admet-36	74	9	and	and	CCONJ
admet-36	74	10	faller	faller	NOUN
admet-36	74	11	admet	admet	PROPN
admet-36	74	12	&	&	CCONJ
admet-36	74	13	dmpk	dmpk	PROPN
admet-36	74	14	2(2	2(2	NUM
admet-36	74	15	)	)	PUNCT
admet-36	74	16	(	(	PUNCT
admet-36	74	17	2014	2014	NUM
admet-36	74	18	)	)	PUNCT
admet-36	74	19	115	115	NUM
admet-36	74	20	-	-	SYM
admet-36	74	21	125	125	NUM
admet-36	74	22	118	118	NUM
admet-36	74	23	according	accord	VERB
admet-36	74	24	to	to	ADP
admet-36	74	25	eq	eq	PROPN
admet-36	74	26	.	.	PUNCT
admet-36	75	1	(	(	PUNCT
admet-36	75	2	1	1	NUM
admet-36	75	3	)	)	PUNCT
admet-36	75	4	,	,	PUNCT
admet-36	75	5	describes	describe	VERB
admet-36	75	6	the	the	DET
admet-36	75	7	solubility	solubility	NOUN
admet-36	75	8	lowering	lower	VERB
admet-36	75	9	effect	effect	NOUN
admet-36	75	10	according	accord	VERB
admet-36	75	11	to	to	ADP
admet-36	75	12	other	other	ADJ
admet-36	75	13	factors	factor	NOUN
admet-36	75	14	than	than	ADP
admet-36	75	15	log	log	VERB
admet-36	75	16	p.	p.	NOUN
admet-36	75	17	one	one	NUM
admet-36	75	18	main	main	ADJ
admet-36	75	19	factor	factor	NOUN
admet-36	75	20	that	that	PRON
admet-36	75	21	limits	limit	VERB
admet-36	75	22	solubility	solubility	NOUN
admet-36	75	23	beyond	beyond	ADP
admet-36	75	24	lipophilicity	lipophilicity	NOUN
admet-36	75	25	is	be	AUX
admet-36	75	26	the	the	DET
admet-36	75	27	contribution	contribution	NOUN
admet-36	75	28	of	of	ADP
admet-36	75	29	crystal	crystal	PROPN
admet-36	75	30	lattice	lattice	PROPN
admet-36	75	31	energy	energy	NOUN
admet-36	75	32	,	,	PUNCT
admet-36	75	33	especially	especially	ADV
admet-36	75	34	for	for	ADP
admet-36	75	35	compounds	compound	NOUN
admet-36	75	36	exhibiting	exhibit	VERB
admet-36	75	37	rather	rather	ADV
admet-36	75	38	high	high	ADJ
admet-36	75	39	melting	melting	NOUN
admet-36	75	40	temperature	temperature	NOUN
admet-36	75	41	.	.	PUNCT
admet-36	76	1	table	table	NOUN
admet-36	76	2	2	2	NUM
admet-36	76	3	.	.	PUNCT
admet-36	76	4	description	description	NOUN
admet-36	76	5	of	of	ADP
admet-36	76	6	parameters	parameter	NOUN
admet-36	76	7	used	use	VERB
admet-36	76	8	for	for	ADP
admet-36	76	9	solubility	solubility	NOUN
admet-36	76	10	diagnosis	diagnosis	NOUN
admet-36	76	11	parameter	parameter	NOUN
admet-36	76	12	description	description	NOUN
admet-36	76	13	remark	remark	NOUN
admet-36	76	14	s0	s0	PROPN
admet-36	76	15	intrinsic	intrinsic	PROPN
admet-36	76	16	solubility	solubility	NOUN
admet-36	76	17	s6.8	s6.8	NOUN
admet-36	76	18	(	(	PUNCT
admet-36	76	19	measured	measure	VERB
admet-36	76	20	)	)	PUNCT
admet-36	76	21	solubility	solubility	NOUN
admet-36	76	22	at	at	ADP
admet-36	76	23	ph	ph	PROPN
admet-36	76	24	6.8	6.8	NUM
admet-36	76	25	measured	measure	VERB
admet-36	76	26	in	in	ADP
admet-36	76	27	buffer	buffer	NOUN
admet-36	76	28	medium	medium	ADJ
admet-36	76	29	s6.8	s6.8	NOUN
admet-36	76	30	(	(	PUNCT
admet-36	76	31	extrapolated	extrapolated	ADJ
admet-36	76	32	)	)	PUNCT
admet-36	76	33	solubility	solubility	NOUN
admet-36	76	34	at	at	ADP
admet-36	76	35	ph6.8	ph6.8	PRON
admet-36	76	36	derived	derive	VERB
admet-36	76	37	from	from	ADP
admet-36	76	38	experimental	experimental	ADJ
admet-36	76	39	pka	pka	PROPN
admet-36	76	40	and	and	CCONJ
admet-36	76	41	logs0	logs0	NOUN
admet-36	76	42	using	use	VERB
admet-36	76	43	the	the	DET
admet-36	76	44	henderson	henderson	PROPN
admet-36	76	45	-	-	PUNCT
admet-36	76	46	hasselbalch	hasselbalch	PROPN
admet-36	76	47	equation	equation	NOUN
admet-36	76	48	fi	fi	NOUN
admet-36	76	49	fraction	fraction	NOUN
admet-36	76	50	ionized	ionize	VERB
admet-36	76	51	ip6.8	ip6.8	ADP
admet-36	76	52	ionization	ionization	NOUN
admet-36	76	53	parameter	parameter	NOUN
admet-36	76	54	at	at	ADP
admet-36	76	55	ph	ph	PROPN
admet-36	76	56	6.8	6.8	NUM
admet-36	76	57	ip	ip	NOUN
admet-36	76	58	=	=	SYM
admet-36	76	59	-log	-log	X
admet-36	76	60	(	(	PUNCT
admet-36	76	61	1	1	NUM
admet-36	76	62	-	-	PUNCT
admet-36	76	63	fi	fi	NOUN
admet-36	76	64	)	)	PUNCT
admet-36	76	65	clogp	clogp	NOUN
admet-36	76	66	calculated	calculate	VERB
admet-36	76	67	logp	logp	NOUN
admet-36	76	68	elogp	elogp	NOUN
admet-36	76	69	experimental	experimental	ADJ
admet-36	76	70	logp	logp	NOUN
admet-36	76	71	sl	sl	NOUN
admet-36	76	72	difference	difference	NOUN
admet-36	76	73	between	between	ADP
admet-36	76	74	solubility	solubility	NOUN
admet-36	76	75	and	and	CCONJ
admet-36	76	76	lipophilicity	lipophilicity	NOUN
admet-36	76	77	sl	sl	NOUN
admet-36	76	78	=	=	SYM
admet-36	76	79	log	log	VERB
admet-36	76	80	1	1	NUM
admet-36	76	81	/	/	SYM
admet-36	76	82	s0	s0	PROPN
admet-36	76	83	–	–	PUNCT
admet-36	76	84	log	log	NOUN
admet-36	76	85	p	p	NOUN
admet-36	76	86	tm	tm	NOUN
admet-36	76	87	melting	melting	NOUN
admet-36	76	88	point	point	NOUN
admet-36	76	89	hf	hf	NOUN
admet-36	76	90	,	,	PUNCT
admet-36	76	91	m	m	PROPN
admet-36	76	92	heat	heat	VERB
admet-36	76	93	of	of	ADP
admet-36	76	94	fusion	fusion	NOUN
admet-36	76	95	at	at	ADP
admet-36	76	96	the	the	DET
admet-36	76	97	melting	melt	VERB
admet-36	76	98	temperature	temperature	NOUN
admet-36	76	99	cf	cf	NOUN
admet-36	76	100	compound	compound	NOUN
admet-36	76	101	formula	formula	NOUN
admet-36	76	102	ah	ah	INTJ
admet-36	76	103	:	:	PUNCT
admet-36	76	104	acid	acid	ADJ
admet-36	76	105	,	,	PUNCT
admet-36	76	106	b	b	NOUN
admet-36	76	107	:	:	PUNCT
admet-36	76	108	base	base	NOUN
admet-36	76	109	,	,	PUNCT
admet-36	76	110	0	0	NUM
admet-36	76	111	:	:	PUNCT
admet-36	76	112	neutral	neutral	ADJ
admet-36	76	113	,	,	PUNCT
admet-36	76	114	xh	xh	PROPN
admet-36	76	115	:	:	PUNCT
admet-36	76	116	ampholyte	ampholyte	ADJ
admet-36	76	117	,	,	PUNCT
admet-36	76	118	zh	zh	PROPN
admet-36	76	119	:	:	PUNCT
admet-36	76	120	zwitterion	zwitterion	NOUN
admet-36	76	121	in	in	ADP
admet-36	76	122	order	order	NOUN
admet-36	76	123	to	to	PART
admet-36	76	124	obtain	obtain	VERB
admet-36	76	125	guidance	guidance	NOUN
admet-36	76	126	in	in	ADP
admet-36	76	127	analyzing	analyze	VERB
admet-36	76	128	the	the	DET
admet-36	76	129	solubility	solubility	NOUN
admet-36	76	130	limiting	limit	VERB
admet-36	76	131	factors	factor	NOUN
admet-36	76	132	of	of	ADP
admet-36	76	133	a	a	DET
admet-36	76	134	given	give	VERB
admet-36	76	135	compound	compound	NOUN
admet-36	76	136	at	at	ADP
admet-36	76	137	a	a	DET
admet-36	76	138	defined	define	VERB
admet-36	76	139	ph	ph	VERB
admet-36	76	140	,	,	PUNCT
admet-36	76	141	table	table	NOUN
admet-36	76	142	3	3	NUM
admet-36	76	143	summarizes	summarize	NOUN
admet-36	76	144	some	some	DET
admet-36	76	145	guidelines	guideline	NOUN
admet-36	76	146	that	that	PRON
admet-36	76	147	help	help	VERB
admet-36	76	148	interpreting	interpret	VERB
admet-36	76	149	the	the	DET
admet-36	76	150	results	result	NOUN
admet-36	76	151	.	.	PUNCT
admet-36	77	1	table	table	NOUN
admet-36	77	2	3	3	NUM
admet-36	77	3	.	.	PUNCT
admet-36	78	1	guidelines	guideline	NOUN
admet-36	78	2	to	to	PART
admet-36	78	3	analyze	analyze	VERB
admet-36	78	4	the	the	DET
admet-36	78	5	solubility	solubility	NOUN
admet-36	78	6	diagnosis	diagnosis	NOUN
admet-36	78	7	dataset	dataset	VERB
admet-36	78	8	column	column	NOUN
admet-36	78	9	guidance	guidance	NOUN
admet-36	78	10	a	a	PRON
admet-36	78	11	and	and	CCONJ
admet-36	78	12	b	b	NOUN
admet-36	78	13	if	if	SCONJ
admet-36	78	14	log	log	VERB
admet-36	78	15	1	1	NUM
admet-36	78	16	/	/	SYM
admet-36	78	17	s6.8	s6.8	NOUN
admet-36	78	18	(	(	PUNCT
admet-36	78	19	measured	measure	VERB
admet-36	78	20	)	)	PUNCT
admet-36	78	21	>	>	PUNCT
admet-36	78	22	>	>	X
admet-36	78	23	log	log	NOUN
admet-36	78	24	1	1	NUM
admet-36	78	25	/	/	SYM
admet-36	78	26	s6.8	s6.8	NOUN
admet-36	78	27	(	(	PUNCT
admet-36	78	28	extrapolated	extrapolated	ADJ
admet-36	78	29	)	)	PUNCT
admet-36	78	30	then	then	ADV
admet-36	78	31	solubility	solubility	NOUN
admet-36	78	32	is	be	AUX
admet-36	78	33	limited	limit	VERB
admet-36	78	34	by	by	ADP
admet-36	78	35	solubility	solubility	NOUN
admet-36	78	36	product	product	NOUN
admet-36	78	37	and/or	and/or	CCONJ
admet-36	78	38	aggregation	aggregation	NOUN
admet-36	78	39	c	c	NOUN
admet-36	78	40	,	,	PUNCT
admet-36	78	41	e	e	PROPN
admet-36	78	42	and	and	CCONJ
admet-36	78	43	f	f	PROPN
admet-36	79	1	if	if	SCONJ
admet-36	79	2	sl	sl	NOUN
admet-36	79	3	>	>	X
admet-36	79	4	2	2	NUM
admet-36	80	1	then	then	ADV
admet-36	80	2	solubility	solubility	NOUN
admet-36	80	3	is	be	AUX
admet-36	80	4	limited	limit	VERB
admet-36	80	5	by	by	ADP
admet-36	80	6	other	other	ADJ
admet-36	80	7	factors	factor	NOUN
admet-36	80	8	than	than	ADP
admet-36	80	9	log	log	VERB
admet-36	80	10	p	p	PROPN
admet-36	80	11	b	b	PROPN
admet-36	80	12	and	and	CCONJ
admet-36	80	13	c	c	NOUN
admet-36	80	14	if	if	SCONJ
admet-36	80	15	log	log	VERB
admet-36	80	16	1	1	NUM
admet-36	80	17	/	/	SYM
admet-36	80	18	s6.8	s6.8	NOUN
admet-36	80	19	(	(	PUNCT
admet-36	80	20	measured	measure	VERB
admet-36	80	21	)	)	PUNCT
admet-36	80	22	or	or	CCONJ
admet-36	80	23	log	log	VERB
admet-36	80	24	1	1	NUM
admet-36	80	25	/	/	SYM
admet-36	80	26	s6.8	s6.8	NOUN
admet-36	80	27	(	(	PUNCT
admet-36	80	28	extrapolated	extrapolate	VERB
admet-36	80	29	)	)	PUNCT
admet-36	80	30	are	be	AUX
admet-36	80	31	close	close	ADJ
admet-36	80	32	to	to	PART
admet-36	80	33	log	log	VERB
admet-36	80	34	1	1	NUM
admet-36	80	35	/	/	SYM
admet-36	80	36	s0	s0	PROPN
admet-36	80	37	then	then	ADV
admet-36	80	38	solubility	solubility	NOUN
admet-36	80	39	is	be	AUX
admet-36	80	40	limited	limit	VERB
admet-36	80	41	by	by	ADP
admet-36	80	42	ionization	ionization	NOUN
admet-36	80	43	f	f	PROPN
admet-36	80	44	and	and	CCONJ
admet-36	80	45	g	g	PROPN
admet-36	80	46	if	if	SCONJ
admet-36	80	47	tm>200	tm>200	NUM
admet-36	80	48	or	or	CCONJ
admet-36	80	49	sl	sl	NOUN
admet-36	81	1	>	>	ADV
admet-36	81	2	2	2	NUM
admet-36	81	3	then	then	ADV
admet-36	81	4	solubility	solubility	NOUN
admet-36	81	5	is	be	AUX
admet-36	81	6	limited	limit	VERB
admet-36	81	7	by	by	ADP
admet-36	81	8	high	high	ADJ
admet-36	81	9	crystal	crystal	PROPN
admet-36	81	10	lattice	lattice	PROPN
admet-36	81	11	energy	energy	PROPN
admet-36	81	12	f	f	PROPN
admet-36	81	13	and	and	CCONJ
admet-36	81	14	g	g	PROPN
admet-36	81	15	tm>200	tm>200	PUNCT
admet-36	81	16	but	but	CCONJ
admet-36	81	17	sl	sl	NOUN
admet-36	81	18	<	<	X
admet-36	81	19	2	2	NUM
admet-36	81	20	indicates	indicate	VERB
admet-36	81	21	possible	possible	ADJ
admet-36	81	22	supersaturation	supersaturation	NOUN
admet-36	81	23	in	in	ADP
admet-36	81	24	the	the	DET
admet-36	81	25	solubility	solubility	NOUN
admet-36	81	26	assay	assay	VERB
admet-36	82	1	i	i	PRON
admet-36	82	2	if	if	SCONJ
admet-36	82	3	compound	compound	NOUN
admet-36	82	4	formula	formula	NOUN
admet-36	82	5	=	=	PUNCT
admet-36	82	6	xh	xh	PROPN
admet-36	82	7	then	then	ADV
admet-36	82	8	solubility	solubility	NOUN
admet-36	82	9	is	be	AUX
admet-36	82	10	usually	usually	ADV
admet-36	82	11	lowest	low	ADJ
admet-36	82	12	at	at	ADP
admet-36	82	13	physiological	physiological	ADJ
admet-36	82	14	ph	ph	NOUN
admet-36	83	1	i	i	PRON
admet-36	83	2	if	if	SCONJ
admet-36	83	3	compound	compound	NOUN
admet-36	83	4	formula	formula	NOUN
admet-36	83	5	=	=	PUNCT
admet-36	83	6	ah	ah	INTJ
admet-36	83	7	then	then	ADV
admet-36	83	8	solubility	solubility	NOUN
admet-36	83	9	is	be	AUX
admet-36	83	10	low	low	ADJ
admet-36	83	11	in	in	ADP
admet-36	83	12	the	the	DET
admet-36	83	13	stomach	stomach	NOUN
admet-36	83	14	admet	admet	PROPN
admet-36	83	15	&	&	CCONJ
admet-36	83	16	dmpk	dmpk	PROPN
admet-36	83	17	2(2	2(2	NUM
admet-36	83	18	)	)	PUNCT
admet-36	83	19	(	(	PUNCT
admet-36	83	20	2014	2014	NUM
admet-36	83	21	)	)	PUNCT
admet-36	83	22	115	115	NUM
admet-36	83	23	-	-	SYM
admet-36	83	24	125	125	NUM
admet-36	83	25	diagnosing	diagnosing	NOUN
admet-36	83	26	solubility	solubility	NOUN
admet-36	83	27	limitations	limitation	NOUN
admet-36	83	28	doi	doi	NOUN
admet-36	83	29	:	:	PUNCT
admet-36	83	30	10.5599	10.5599	NUM
admet-36	83	31	/	/	SYM
admet-36	83	32	admet.2.2.36	admet.2.2.36	VERB
admet-36	83	33	119	119	NUM
admet-36	83	34	results	result	NOUN
admet-36	83	35	and	and	CCONJ
admet-36	83	36	discussion	discussion	NOUN
admet-36	83	37	what	what	DET
admet-36	83	38	factors	factor	NOUN
admet-36	83	39	do	do	VERB
admet-36	83	40	influence	influence	NOUN
admet-36	83	41	compound	compound	NOUN
admet-36	83	42	solubility	solubility	NOUN
admet-36	83	43	?	?	PUNCT
admet-36	84	1	the	the	DET
admet-36	84	2	solubility	solubility	NOUN
admet-36	84	3	of	of	ADP
admet-36	84	4	a	a	DET
admet-36	84	5	compound	compound	NOUN
admet-36	84	6	is	be	AUX
admet-36	84	7	mainly	mainly	ADV
admet-36	84	8	influenced	influence	VERB
admet-36	84	9	by	by	ADP
admet-36	84	10	its	its	PRON
admet-36	84	11	solute	solute	ADJ
admet-36	84	12	-	-	PUNCT
admet-36	84	13	solvent	solvent	NOUN
admet-36	84	14	interaction	interaction	NOUN
admet-36	84	15	,	,	PUNCT
admet-36	84	16	its	its	PRON
admet-36	84	17	solid	solid	ADJ
admet-36	84	18	-	-	PUNCT
admet-36	84	19	state	state	NOUN
admet-36	84	20	interaction	interaction	NOUN
admet-36	84	21	[	[	X
admet-36	84	22	13	13	NUM
admet-36	84	23	]	]	PUNCT
admet-36	84	24	as	as	ADV
admet-36	84	25	well	well	ADV
admet-36	84	26	as	as	ADP
admet-36	84	27	its	its	PRON
admet-36	84	28	ionization	ionization	NOUN
admet-36	84	29	state	state	NOUN
admet-36	84	30	.	.	PUNCT
admet-36	85	1	from	from	ADP
admet-36	85	2	these	these	DET
admet-36	85	3	three	three	NUM
admet-36	85	4	main	main	ADJ
admet-36	85	5	factors	factor	NOUN
admet-36	85	6	,	,	PUNCT
admet-36	85	7	the	the	DET
admet-36	85	8	solute	solute	NOUN
admet-36	85	9	-	-	PUNCT
admet-36	85	10	solvent	solvent	ADJ
admet-36	85	11	interactions	interaction	NOUN
admet-36	85	12	are	be	AUX
admet-36	85	13	typically	typically	ADV
admet-36	85	14	described	describe	VERB
admet-36	85	15	by	by	ADP
admet-36	85	16	the	the	DET
admet-36	85	17	partition	partition	NOUN
admet-36	85	18	coefficient	coefficient	NOUN
admet-36	85	19	log	log	VERB
admet-36	85	20	p	p	PROPN
admet-36	86	1	[	[	X
admet-36	86	2	14	14	NUM
admet-36	86	3	]	]	PUNCT
admet-36	86	4	.	.	PUNCT
admet-36	87	1	the	the	DET
admet-36	87	2	log	log	NOUN
admet-36	87	3	p	p	NOUN
admet-36	87	4	value	value	NOUN
admet-36	87	5	is	be	AUX
admet-36	87	6	an	an	DET
admet-36	87	7	intrinsic	intrinsic	ADJ
admet-36	87	8	property	property	NOUN
admet-36	87	9	of	of	ADP
admet-36	87	10	a	a	DET
admet-36	87	11	molecule	molecule	NOUN
admet-36	87	12	and	and	CCONJ
admet-36	87	13	thus	thus	ADV
admet-36	87	14	depends	depend	VERB
admet-36	87	15	on	on	ADP
admet-36	87	16	its	its	PRON
admet-36	87	17	chemical	chemical	ADJ
admet-36	87	18	constitution	constitution	NOUN
admet-36	87	19	.	.	PUNCT
admet-36	88	1	in	in	ADP
admet-36	88	2	contrast	contrast	NOUN
admet-36	88	3	,	,	PUNCT
admet-36	88	4	solid	solid	ADJ
admet-36	88	5	state	state	NOUN
admet-36	88	6	properties	property	NOUN
admet-36	88	7	are	be	AUX
admet-36	88	8	accessible	accessible	ADJ
admet-36	88	9	to	to	ADP
admet-36	88	10	changes	change	NOUN
admet-36	88	11	of	of	ADP
admet-36	88	12	the	the	DET
admet-36	88	13	solid	solid	ADJ
admet-36	88	14	form	form	NOUN
admet-36	88	15	.	.	PUNCT
admet-36	89	1	various	various	ADJ
admet-36	89	2	solid	solid	ADJ
admet-36	89	3	forms	form	NOUN
admet-36	89	4	comprise	comprise	VERB
admet-36	89	5	the	the	DET
admet-36	89	6	thermodynamically	thermodynamically	ADV
admet-36	89	7	most	most	ADV
admet-36	89	8	stable	stable	ADJ
admet-36	89	9	crystalline	crystalline	NOUN
admet-36	89	10	form	form	NOUN
admet-36	89	11	as	as	ADV
admet-36	89	12	well	well	ADV
admet-36	89	13	as	as	ADP
admet-36	89	14	further	further	ADJ
admet-36	89	15	polymorphic	polymorphic	ADJ
admet-36	89	16	forms	form	NOUN
admet-36	89	17	that	that	PRON
admet-36	89	18	may	may	AUX
admet-36	89	19	exist	exist	VERB
admet-36	89	20	,	,	PUNCT
admet-36	89	21	including	include	VERB
admet-36	89	22	the	the	DET
admet-36	89	23	amorphous	amorphous	ADJ
admet-36	89	24	state	state	NOUN
admet-36	89	25	as	as	ADV
admet-36	89	26	well	well	ADV
admet-36	89	27	as	as	ADP
admet-36	89	28	solvates	solvate	NOUN
admet-36	89	29	and	and	CCONJ
admet-36	89	30	hydrates	hydrate	NOUN
admet-36	89	31	.	.	PUNCT
admet-36	90	1	it	it	PRON
admet-36	90	2	should	should	AUX
admet-36	90	3	therefore	therefore	ADV
admet-36	90	4	be	be	AUX
admet-36	90	5	obvious	obvious	ADJ
admet-36	90	6	that	that	SCONJ
admet-36	90	7	the	the	DET
admet-36	90	8	nature	nature	NOUN
admet-36	90	9	of	of	ADP
admet-36	90	10	the	the	DET
admet-36	90	11	solid	solid	ADJ
admet-36	90	12	form	form	NOUN
admet-36	90	13	has	have	VERB
admet-36	90	14	to	to	PART
admet-36	90	15	be	be	AUX
admet-36	90	16	well	well	ADV
admet-36	90	17	characterized	characterize	VERB
admet-36	90	18	in	in	ADP
admet-36	90	19	order	order	NOUN
admet-36	90	20	to	to	PART
admet-36	90	21	understand	understand	VERB
admet-36	90	22	the	the	DET
admet-36	90	23	solid	solid	ADJ
admet-36	90	24	state	state	NOUN
admet-36	90	25	contribution	contribution	NOUN
admet-36	90	26	to	to	ADP
admet-36	90	27	solubility	solubility	NOUN
admet-36	90	28	limitation	limitation	NOUN
admet-36	90	29	.	.	PUNCT
admet-36	91	1	the	the	DET
admet-36	91	2	ionization	ionization	NOUN
admet-36	91	3	state	state	NOUN
admet-36	91	4	of	of	ADP
admet-36	91	5	a	a	DET
admet-36	91	6	compound	compound	NOUN
admet-36	91	7	is	be	AUX
admet-36	91	8	defined	define	VERB
admet-36	91	9	by	by	ADP
admet-36	91	10	its	its	PRON
admet-36	91	11	chemical	chemical	NOUN
admet-36	91	12	structure	structure	NOUN
admet-36	91	13	and	and	CCONJ
admet-36	91	14	consequently	consequently	ADV
admet-36	91	15	by	by	ADP
admet-36	91	16	its	its	PRON
admet-36	91	17	pka	pka	PROPN
admet-36	91	18	values	value	NOUN
admet-36	91	19	.	.	PUNCT
admet-36	92	1	generally	generally	ADV
admet-36	92	2	,	,	PUNCT
admet-36	92	3	the	the	DET
admet-36	92	4	ionization	ionization	NOUN
admet-36	92	5	state	state	NOUN
admet-36	92	6	of	of	ADP
admet-36	92	7	a	a	DET
admet-36	92	8	molecule	molecule	NOUN
admet-36	92	9	depends	depend	VERB
admet-36	92	10	on	on	ADP
admet-36	92	11	the	the	DET
admet-36	92	12	pka	pka	PROPN
admet-36	92	13	value	value	NOUN
admet-36	92	14	of	of	ADP
admet-36	92	15	the	the	DET
admet-36	92	16	surrounding	surround	VERB
admet-36	92	17	solvent	solvent	NOUN
admet-36	92	18	,	,	PUNCT
admet-36	92	19	too	too	ADV
admet-36	92	20	.	.	PUNCT
admet-36	93	1	in	in	ADP
admet-36	93	2	an	an	DET
admet-36	93	3	aqueous	aqueous	ADJ
admet-36	93	4	environment	environment	NOUN
admet-36	93	5	,	,	PUNCT
admet-36	93	6	its	its	PRON
admet-36	93	7	ionization	ionization	NOUN
admet-36	93	8	state	state	NOUN
admet-36	93	9	is	be	AUX
admet-36	93	10	a	a	DET
admet-36	93	11	function	function	NOUN
admet-36	93	12	of	of	ADP
admet-36	93	13	the	the	DET
admet-36	93	14	ph	ph	ADJ
admet-36	93	15	value	value	NOUN
admet-36	93	16	.	.	PUNCT
admet-36	94	1	thus	thus	ADV
admet-36	94	2	,	,	PUNCT
admet-36	94	3	for	for	ADP
admet-36	94	4	a	a	DET
admet-36	94	5	drug	drug	NOUN
admet-36	94	6	-	-	PUNCT
admet-36	94	7	like	like	ADJ
admet-36	94	8	molecule	molecule	NOUN
admet-36	94	9	,	,	PUNCT
admet-36	94	10	a	a	DET
admet-36	94	11	bio	bio	ADJ
admet-36	94	12	-	-	ADJ
admet-36	94	13	relevant	relevant	ADJ
admet-36	94	14	ph	ph	NOUN
admet-36	94	15	value	value	NOUN
admet-36	94	16	needs	need	VERB
admet-36	94	17	to	to	PART
admet-36	94	18	be	be	AUX
admet-36	94	19	defined	define	VERB
admet-36	94	20	that	that	PRON
admet-36	94	21	is	be	AUX
admet-36	94	22	relevant	relevant	ADJ
admet-36	94	23	for	for	ADP
admet-36	94	24	its	its	PRON
admet-36	94	25	solubility	solubility	NOUN
admet-36	94	26	at	at	ADP
admet-36	94	27	the	the	DET
admet-36	94	28	site	site	NOUN
admet-36	94	29	of	of	ADP
admet-36	94	30	absorption	absorption	NOUN
admet-36	94	31	.	.	PUNCT
admet-36	95	1	here	here	ADV
admet-36	95	2	,	,	PUNCT
admet-36	95	3	a	a	DET
admet-36	95	4	ph	ph	ADJ
admet-36	95	5	value	value	NOUN
admet-36	95	6	of	of	ADP
admet-36	95	7	6.8	6.8	NUM
admet-36	95	8	is	be	AUX
admet-36	95	9	chosen	choose	VERB
admet-36	95	10	even	even	ADV
admet-36	95	11	though	though	SCONJ
admet-36	95	12	a	a	DET
admet-36	95	13	different	different	ADJ
admet-36	95	14	value	value	NOUN
admet-36	95	15	might	might	AUX
admet-36	95	16	be	be	AUX
admet-36	95	17	more	more	ADV
admet-36	95	18	appropriate	appropriate	ADJ
admet-36	95	19	based	base	VERB
admet-36	95	20	on	on	ADP
admet-36	95	21	the	the	DET
admet-36	95	22	ph	ph	ADJ
admet-36	95	23	gradient	gradient	NOUN
admet-36	95	24	in	in	ADP
admet-36	95	25	the	the	DET
admet-36	95	26	gastro	gastro	ADJ
admet-36	95	27	-	-	PUNCT
admet-36	95	28	intestinal	intestinal	ADJ
admet-36	95	29	tract	tract	NOUN
admet-36	95	30	or	or	CCONJ
admet-36	95	31	when	when	SCONJ
admet-36	95	32	a	a	DET
admet-36	95	33	non	non	ADJ
admet-36	95	34	-	-	ADJ
admet-36	95	35	oral	oral	ADJ
admet-36	95	36	route	route	NOUN
admet-36	95	37	of	of	ADP
admet-36	95	38	administration	administration	NOUN
admet-36	95	39	is	be	AUX
admet-36	95	40	considered	consider	VERB
admet-36	95	41	.	.	PUNCT
admet-36	96	1	solid	solid	ADJ
admet-36	96	2	-	-	PUNCT
admet-36	96	3	state	state	NOUN
admet-36	96	4	and	and	CCONJ
admet-36	96	5	lipophilicity	lipophilicity	NOUN
admet-36	96	6	–	–	PUNCT
admet-36	96	7	which	which	DET
admet-36	96	8	one	one	NOUN
admet-36	96	9	is	be	AUX
admet-36	96	10	easier	easy	ADJ
admet-36	96	11	to	to	PART
admet-36	96	12	handle	handle	VERB
admet-36	96	13	?	?	PUNCT
admet-36	97	1	which	which	PRON
admet-36	97	2	of	of	ADP
admet-36	97	3	the	the	DET
admet-36	97	4	hurdles	hurdle	NOUN
admet-36	97	5	contributing	contribute	VERB
admet-36	97	6	to	to	ADP
admet-36	97	7	solubility	solubility	NOUN
admet-36	97	8	limitations	limitation	NOUN
admet-36	97	9	can	can	AUX
admet-36	97	10	be	be	AUX
admet-36	97	11	overcome	overcome	VERB
admet-36	97	12	more	more	ADV
admet-36	97	13	easily	easily	ADV
admet-36	97	14	?	?	PUNCT
admet-36	98	1	in	in	ADP
admet-36	98	2	the	the	DET
admet-36	98	3	case	case	NOUN
admet-36	98	4	of	of	ADP
admet-36	98	5	solute	solute	ADJ
admet-36	98	6	-	-	PUNCT
admet-36	98	7	solvent	solvent	ADJ
admet-36	98	8	interactions	interaction	NOUN
admet-36	98	9	,	,	PUNCT
admet-36	98	10	the	the	DET
admet-36	98	11	only	only	ADJ
admet-36	98	12	way	way	NOUN
admet-36	98	13	to	to	PART
admet-36	98	14	impact	impact	VERB
admet-36	98	15	the	the	DET
admet-36	98	16	log	log	NOUN
admet-36	98	17	p	p	NOUN
admet-36	98	18	is	be	AUX
admet-36	98	19	during	during	ADP
admet-36	98	20	lead	lead	ADJ
admet-36	98	21	optimization	optimization	NOUN
admet-36	98	22	.	.	PUNCT
admet-36	99	1	certainly	certainly	ADV
admet-36	99	2	,	,	PUNCT
admet-36	99	3	the	the	DET
admet-36	99	4	room	room	NOUN
admet-36	99	5	for	for	ADP
admet-36	99	6	maneuver	maneuver	NOUN
admet-36	99	7	is	be	AUX
admet-36	99	8	often	often	ADV
admet-36	99	9	limited	limit	VERB
admet-36	99	10	for	for	ADP
admet-36	99	11	the	the	DET
admet-36	99	12	medicinal	medicinal	ADJ
admet-36	99	13	chemist	chemist	NOUN
admet-36	99	14	due	due	ADP
admet-36	99	15	to	to	ADP
admet-36	99	16	the	the	DET
admet-36	99	17	need	need	NOUN
admet-36	99	18	to	to	PART
admet-36	99	19	balance	balance	VERB
admet-36	99	20	molecular	molecular	ADJ
admet-36	99	21	properties	property	NOUN
admet-36	99	22	,	,	PUNCT
admet-36	99	23	especially	especially	ADV
admet-36	99	24	not	not	PART
admet-36	99	25	to	to	PART
admet-36	99	26	lose	lose	VERB
admet-36	99	27	potency	potency	NOUN
admet-36	99	28	on	on	ADP
admet-36	99	29	the	the	DET
admet-36	99	30	relevant	relevant	ADJ
admet-36	99	31	target	target	NOUN
admet-36	99	32	.	.	PUNCT
admet-36	100	1	in	in	ADP
admet-36	100	2	other	other	ADJ
admet-36	100	3	words	word	NOUN
admet-36	100	4	,	,	PUNCT
admet-36	100	5	medicinal	medicinal	ADJ
admet-36	100	6	chemistry	chemistry	NOUN
admet-36	100	7	will	will	AUX
admet-36	100	8	not	not	PART
admet-36	100	9	be	be	AUX
admet-36	100	10	able	able	ADJ
admet-36	100	11	to	to	PART
admet-36	100	12	avoid	avoid	VERB
admet-36	100	13	a	a	DET
admet-36	100	14	certain	certain	ADJ
admet-36	100	15	level	level	NOUN
admet-36	100	16	of	of	ADP
admet-36	100	17	lipophilicity	lipophilicity	NOUN
admet-36	100	18	.	.	PUNCT
admet-36	101	1	as	as	SCONJ
admet-36	101	2	other	other	ADJ
admet-36	101	3	factors	factor	NOUN
admet-36	101	4	will	will	AUX
admet-36	101	5	add	add	VERB
admet-36	101	6	up	up	ADP
admet-36	101	7	which	which	PRON
admet-36	101	8	further	far	ADV
admet-36	101	9	decrease	decrease	NOUN
admet-36	101	10	solubility	solubility	NOUN
admet-36	101	11	of	of	ADP
admet-36	101	12	a	a	DET
admet-36	101	13	molecule	molecule	NOUN
admet-36	102	1	[	[	X
admet-36	102	2	12	12	NUM
admet-36	102	3	]	]	PUNCT
admet-36	102	4	,	,	PUNCT
admet-36	102	5	it	it	PRON
admet-36	102	6	appears	appear	VERB
admet-36	102	7	a	a	DET
admet-36	102	8	reasonable	reasonable	ADJ
admet-36	102	9	strategy	strategy	NOUN
admet-36	102	10	to	to	PART
admet-36	102	11	avoid	avoid	VERB
admet-36	102	12	further	further	ADJ
admet-36	102	13	contributions	contribution	NOUN
admet-36	102	14	that	that	PRON
admet-36	102	15	negatively	negatively	ADV
admet-36	102	16	affect	affect	VERB
admet-36	102	17	compound	compound	NOUN
admet-36	102	18	solubility	solubility	NOUN
admet-36	102	19	,	,	PUNCT
admet-36	102	20	including	include	VERB
admet-36	102	21	solid	solid	ADJ
admet-36	102	22	state	state	NOUN
admet-36	102	23	contributions	contribution	NOUN
admet-36	102	24	.	.	PUNCT
admet-36	103	1	it	it	PRON
admet-36	103	2	is	be	AUX
admet-36	103	3	worth	worth	ADJ
admet-36	103	4	mentioning	mention	VERB
admet-36	103	5	that	that	SCONJ
admet-36	103	6	solid	solid	ADJ
admet-36	103	7	-	-	PUNCT
admet-36	103	8	state	state	NOUN
admet-36	103	9	properties	property	NOUN
admet-36	103	10	are	be	AUX
admet-36	103	11	determined	determine	VERB
admet-36	103	12	by	by	ADP
admet-36	103	13	molecular	molecular	ADJ
admet-36	103	14	constitution	constitution	NOUN
admet-36	103	15	,	,	PUNCT
admet-36	103	16	as	as	ADV
admet-36	103	17	well	well	ADV
admet-36	103	18	.	.	PUNCT
admet-36	104	1	thus	thus	ADV
admet-36	104	2	,	,	PUNCT
admet-36	104	3	many	many	ADJ
admet-36	104	4	lead	lead	NOUN
admet-36	104	5	structures	structure	NOUN
admet-36	104	6	favor	favor	VERB
admet-36	104	7	strong	strong	ADJ
admet-36	104	8	molecular	molecular	ADJ
admet-36	104	9	interactions	interaction	NOUN
admet-36	104	10	and	and	CCONJ
admet-36	104	11	increasing	increase	VERB
admet-36	104	12	their	their	PRON
admet-36	104	13	solubility	solubility	NOUN
admet-36	104	14	by	by	ADP
admet-36	104	15	lead	lead	NOUN
admet-36	104	16	optimization	optimization	NOUN
admet-36	104	17	will	will	AUX
admet-36	104	18	remain	remain	VERB
admet-36	104	19	a	a	DET
admet-36	104	20	challenging	challenging	ADJ
admet-36	104	21	task	task	NOUN
admet-36	105	1	[	[	X
admet-36	105	2	15][16	15][16	PROPN
admet-36	105	3	]	]	PUNCT
admet-36	105	4	.	.	PUNCT
admet-36	106	1	despite	despite	SCONJ
admet-36	106	2	the	the	DET
admet-36	106	3	fact	fact	NOUN
admet-36	106	4	that	that	SCONJ
admet-36	106	5	the	the	DET
admet-36	106	6	solid	solid	ADJ
admet-36	106	7	state	state	NOUN
admet-36	106	8	can	can	AUX
admet-36	106	9	be	be	AUX
admet-36	106	10	impacted	impact	VERB
admet-36	106	11	by	by	ADP
admet-36	106	12	formulation	formulation	NOUN
admet-36	106	13	efforts	effort	NOUN
admet-36	106	14	,	,	PUNCT
admet-36	106	15	it	it	PRON
admet-36	106	16	has	have	AUX
admet-36	106	17	been	be	AUX
admet-36	106	18	shown	show	VERB
admet-36	106	19	that	that	SCONJ
admet-36	106	20	compounds	compound	VERB
admet-36	106	21	that	that	PRON
admet-36	106	22	show	show	VERB
admet-36	106	23	mainly	mainly	ADV
admet-36	106	24	solvation	solvation	NOUN
admet-36	106	25	limited	limit	VERB
admet-36	106	26	solubility	solubility	NOUN
admet-36	106	27	appear	appear	VERB
admet-36	106	28	to	to	PART
admet-36	106	29	have	have	VERB
admet-36	106	30	a	a	DET
admet-36	106	31	higher	high	ADJ
admet-36	106	32	chance	chance	NOUN
admet-36	106	33	to	to	PART
admet-36	106	34	successfully	successfully	ADV
admet-36	106	35	reach	reach	VERB
admet-36	106	36	the	the	DET
admet-36	106	37	market	market	NOUN
admet-36	106	38	[	[	X
admet-36	106	39	17	17	NUM
admet-36	106	40	]	]	PUNCT
admet-36	106	41	.	.	PUNCT
admet-36	107	1	organic	organic	ADJ
admet-36	107	2	hydrates	hydrate	NOUN
admet-36	107	3	in	in	ADP
admet-36	107	4	solubility	solubility	NOUN
admet-36	107	5	diagnosis	diagnosis	NOUN
admet-36	107	6	in	in	ADP
admet-36	107	7	the	the	DET
admet-36	107	8	lead	lead	ADJ
admet-36	107	9	optimization	optimization	NOUN
admet-36	107	10	phase	phase	NOUN
admet-36	107	11	,	,	PUNCT
admet-36	107	12	solid	solid	ADJ
admet-36	107	13	state	state	NOUN
admet-36	107	14	properties	property	NOUN
admet-36	107	15	are	be	AUX
admet-36	107	16	typically	typically	ADV
admet-36	107	17	not	not	PART
admet-36	107	18	evaluated	evaluate	VERB
admet-36	107	19	in	in	ADP
admet-36	107	20	detail	detail	NOUN
admet-36	107	21	,	,	PUNCT
admet-36	107	22	if	if	SCONJ
admet-36	107	23	at	at	ADV
admet-36	107	24	all	all	ADV
admet-36	107	25	.	.	PUNCT
admet-36	108	1	bearing	bear	VERB
admet-36	108	2	in	in	ADP
admet-36	108	3	mind	mind	NOUN
admet-36	108	4	the	the	DET
admet-36	108	5	awareness	awareness	NOUN
admet-36	108	6	of	of	ADP
admet-36	108	7	solid	solid	ADJ
admet-36	108	8	state	state	NOUN
admet-36	108	9	contributions	contribution	NOUN
admet-36	108	10	to	to	ADP
admet-36	108	11	solubility	solubility	NOUN
admet-36	108	12	limitation	limitation	NOUN
admet-36	108	13	,	,	PUNCT
admet-36	108	14	an	an	DET
admet-36	108	15	attempt	attempt	NOUN
admet-36	108	16	was	be	AUX
admet-36	108	17	made	make	VERB
admet-36	108	18	to	to	PART
admet-36	108	19	understand	understand	VERB
admet-36	108	20	the	the	DET
admet-36	108	21	impact	impact	NOUN
admet-36	108	22	of	of	ADP
admet-36	108	23	such	such	ADJ
admet-36	108	24	solid	solid	ADJ
admet-36	108	25	form	form	NOUN
admet-36	108	26	changes	change	NOUN
admet-36	108	27	on	on	ADP
admet-36	108	28	the	the	DET
admet-36	108	29	solubility	solubility	NOUN
admet-36	108	30	diagnosis	diagnosis	NOUN
admet-36	108	31	results	result	NOUN
admet-36	108	32	.	.	PUNCT
admet-36	109	1	as	as	ADP
admet-36	109	2	an	an	DET
admet-36	109	3	example	example	NOUN
admet-36	109	4	,	,	PUNCT
admet-36	109	5	hydrate	hydrate	ADJ
admet-36	109	6	formation	formation	NOUN
admet-36	109	7	was	be	AUX
admet-36	109	8	selected	select	VERB
admet-36	109	9	.	.	PUNCT
admet-36	110	1	as	as	SCONJ
admet-36	110	2	the	the	DET
admet-36	110	3	performance	performance	NOUN
admet-36	110	4	of	of	ADP
admet-36	110	5	drug	drug	NOUN
admet-36	110	6	compounds	compound	NOUN
admet-36	110	7	is	be	AUX
admet-36	110	8	investigated	investigate	VERB
admet-36	110	9	in	in	ADP
admet-36	110	10	aqueous	aqueous	ADJ
admet-36	110	11	environment	environment	NOUN
admet-36	110	12	where	where	SCONJ
admet-36	110	13	the	the	DET
admet-36	110	14	formation	formation	NOUN
admet-36	110	15	of	of	ADP
admet-36	110	16	hydrate	hydrate	ADJ
admet-36	110	17	forms	form	NOUN
admet-36	110	18	can	can	AUX
admet-36	110	19	negatively	negatively	ADV
admet-36	110	20	impact	impact	VERB
admet-36	110	21	its	its	PRON
admet-36	110	22	solubility	solubility	NOUN
admet-36	110	23	,	,	PUNCT
admet-36	110	24	the	the	DET
admet-36	110	25	stability	stability	NOUN
admet-36	110	26	of	of	ADP
admet-36	110	27	the	the	DET
admet-36	110	28	solid	solid	ADJ
admet-36	110	29	form	form	NOUN
admet-36	110	30	under	under	ADP
admet-36	110	31	investigation	investigation	NOUN
admet-36	110	32	may	may	AUX
admet-36	110	33	implicate	implicate	VERB
admet-36	110	34	the	the	DET
admet-36	110	35	conclusions	conclusion	NOUN
admet-36	110	36	drawn	draw	VERB
admet-36	110	37	on	on	ADP
admet-36	110	38	solubility	solubility	NOUN
admet-36	110	39	limitation	limitation	NOUN
admet-36	110	40	.	.	PUNCT
admet-36	111	1	for	for	ADP
admet-36	111	2	this	this	PRON
admet-36	111	3	,	,	PUNCT
admet-36	111	4	selected	select	VERB
admet-36	111	5	compounds	compound	NOUN
admet-36	111	6	from	from	ADP
admet-36	111	7	in	in	ADP
admet-36	111	8	-	-	PUNCT
admet-36	111	9	house	house	NOUN
admet-36	111	10	lead	lead	NOUN
admet-36	111	11	optimization	optimization	NOUN
admet-36	111	12	projects	project	NOUN
admet-36	111	13	as	as	ADV
admet-36	111	14	well	well	ADV
admet-36	111	15	as	as	ADP
admet-36	111	16	marketed	market	VERB
admet-36	111	17	drugs	drug	NOUN
admet-36	111	18	were	be	AUX
admet-36	111	19	examined	examine	VERB
admet-36	111	20	,	,	PUNCT
admet-36	111	21	which	which	PRON
admet-36	111	22	all	all	PRON
admet-36	111	23	of	of	ADP
admet-36	111	24	them	they	PRON
admet-36	111	25	are	be	AUX
admet-36	111	26	known	know	VERB
admet-36	111	27	to	to	PART
admet-36	111	28	form	form	VERB
admet-36	111	29	hydrates	hydrate	NOUN
admet-36	111	30	.	.	PUNCT
admet-36	112	1	for	for	ADP
admet-36	112	2	proprietary	proprietary	ADJ
admet-36	112	3	compounds	compound	NOUN
admet-36	112	4	,	,	PUNCT
admet-36	112	5	hydrate	hydrate	ADJ
admet-36	112	6	formation	formation	NOUN
admet-36	112	7	has	have	AUX
admet-36	112	8	been	be	AUX
admet-36	112	9	confirmed	confirm	VERB
admet-36	112	10	by	by	ADP
admet-36	112	11	in	in	ADP
admet-36	112	12	-	-	PUNCT
admet-36	112	13	depth	depth	NOUN
admet-36	112	14	solid	solid	ADJ
admet-36	112	15	state	state	NOUN
admet-36	112	16	analysis	analysis	NOUN
admet-36	112	17	.	.	PUNCT
admet-36	113	1	investigation	investigation	NOUN
admet-36	113	2	results	result	VERB
admet-36	113	3	on	on	ADP
admet-36	113	4	nitrofurantoin	nitrofurantoin	NOUN
admet-36	113	5	and	and	CCONJ
admet-36	113	6	carbamazepine	carbamazepine	NOUN
admet-36	113	7	are	be	AUX
admet-36	113	8	publicly	publicly	ADV
admet-36	113	9	available	available	ADJ
admet-36	113	10	.	.	PUNCT
admet-36	114	1	the	the	DET
admet-36	114	2	following	follow	VERB
admet-36	114	3	table	table	NOUN
admet-36	114	4	(	(	PUNCT
admet-36	114	5	table	table	NOUN
admet-36	114	6	4	4	NUM
admet-36	114	7	)	)	PUNCT
admet-36	114	8	summarizes	summarize	VERB
admet-36	114	9	the	the	DET
admet-36	114	10	solubility	solubility	NOUN
admet-36	114	11	diagnosis	diagnosis	NOUN
admet-36	114	12	for	for	ADP
admet-36	114	13	the	the	DET
admet-36	114	14	selected	select	VERB
admet-36	114	15	compounds	compound	NOUN
admet-36	114	16	.	.	PUNCT
admet-36	115	1	in	in	ADP
admet-36	115	2	addition	addition	NOUN
admet-36	115	3	,	,	PUNCT
admet-36	115	4	the	the	DET
admet-36	115	5	psa	psa	NOUN
admet-36	115	6	values	value	NOUN
admet-36	115	7	are	be	AUX
admet-36	115	8	included	include	VERB
admet-36	115	9	to	to	PART
admet-36	115	10	facilitate	facilitate	VERB
admet-36	115	11	discussion	discussion	NOUN
admet-36	115	12	of	of	ADP
admet-36	115	13	figure	figure	NOUN
admet-36	115	14	2	2	NUM
admet-36	115	15	.	.	PUNCT
admet-36	115	16	berghausen	berghausen	NOUN
admet-36	115	17	and	and	CCONJ
admet-36	115	18	faller	faller	NOUN
admet-36	115	19	admet	admet	PROPN
admet-36	115	20	&	&	CCONJ
admet-36	115	21	dmpk	dmpk	PROPN
admet-36	115	22	2(2	2(2	NUM
admet-36	115	23	)	)	PUNCT
admet-36	115	24	(	(	PUNCT
admet-36	115	25	2014	2014	NUM
admet-36	115	26	)	)	PUNCT
admet-36	115	27	115	115	NUM
admet-36	115	28	-	-	SYM
admet-36	115	29	125	125	NUM
admet-36	115	30	120	120	NUM
admet-36	115	31	table	table	NOUN
admet-36	115	32	4	4	NUM
admet-36	115	33	.	.	PUNCT
admet-36	116	1	examples	example	NOUN
admet-36	116	2	of	of	ADP
admet-36	116	3	hydrates	hydrate	NOUN
admet-36	116	4	in	in	ADP
admet-36	116	5	solubility	solubility	NOUN
admet-36	116	6	diagnosis	diagnosis	NOUN
admet-36	116	7	a	a	DET
admet-36	116	8	b	b	NOUN
admet-36	116	9	c	c	NOUN
admet-36	116	10	d	d	X
admet-36	116	11	e	e	X
admet-36	116	12	f	f	PROPN
admet-36	117	1	g	g	NOUN
admet-36	117	2	h	h	NOUN
admet-36	117	3	i	i	PRON
admet-36	117	4	psa	psa	VERB
admet-36	117	5	log1	log1	PROPN
admet-36	117	6	/	/	SYM
admet-36	117	7	s6.8	s6.8	PROPN
admet-36	117	8	(	(	PUNCT
admet-36	117	9	measured	measure	VERB
admet-36	117	10	)	)	PUNCT
admet-36	117	11	log1	log1	PROPN
admet-36	117	12	/	/	SYM
admet-36	117	13	s6.8	s6.8	PROPN
admet-36	117	14	(	(	PUNCT
admet-36	117	15	extrapolated	extrapolated	ADJ
admet-36	117	16	)	)	PUNCT
admet-36	117	17	log1	log1	PROPN
admet-36	117	18	/	/	SYM
admet-36	117	19	s0	s0	PROPN
admet-36	117	20	ip6.8	ip6.8	ADP
admet-36	117	21	elogp	elogp	NOUN
admet-36	117	22	sl	sl	NOUN
admet-36	117	23	tm	tm	PROPN
admet-36	117	24	hf	hf	NOUN
admet-36	117	25	,	,	PUNCT
admet-36	117	26	m	m	PROPN
admet-36	117	27	cf	cf	NOUN
admet-36	117	28	cpd1	cpd1	NOUN
admet-36	117	29	4.4	4.4	NUM
admet-36	117	30	4.4	4.4	NUM
admet-36	117	31	4.9	4.9	NUM
admet-36	117	32	0.48	0.48	NUM
admet-36	117	33	3.8	3.8	NUM
admet-36	117	34	1.1	1.1	NUM
admet-36	117	35	97.1	97.1	NUM
admet-36	117	36	12.6	12.6	NUM
admet-36	117	37	b	b	NUM
admet-36	117	38	113	113	NUM
admet-36	117	39	cpd2	cpd2	NOUN
admet-36	117	40	4.9	4.9	NUM
admet-36	117	41	3.9	3.9	NUM
admet-36	117	42	3.9	3.9	NUM
admet-36	117	43	0.0	0.0	NUM
admet-36	117	44	5.0	5.0	NUM
admet-36	117	45	-1.1	-1.1	NOUN
admet-36	117	46	243.7	243.7	NUM
admet-36	117	47	22.1	22.1	NUM
admet-36	117	48	zh2	zh2	NOUN
admet-36	117	49	57	57	NUM
admet-36	117	50	cpd3	cpd3	VERB
admet-36	117	51	4.0	4.0	NUM
admet-36	117	52	3.5	3.5	NUM
admet-36	117	53	5	5	NUM
admet-36	117	54	1.5	1.5	NUM
admet-36	117	55	4.1	4.1	NUM
admet-36	117	56	0.9	0.9	NUM
admet-36	117	57	177.2	177.2	NUM
admet-36	117	58	29.7	29.7	NUM
admet-36	117	59	ah	ah	INTJ
admet-36	117	60	134	134	NUM
admet-36	117	61	cpd4	cpd4	NOUN
admet-36	117	62	6	6	NUM
admet-36	117	63	6.1	6.1	NUM
admet-36	117	64	6.1	6.1	NUM
admet-36	117	65	0.0	0.0	NUM
admet-36	117	66	3.1	3.1	NUM
admet-36	117	67	3.0	3.0	NUM
admet-36	117	68	133.6	133.6	NUM
admet-36	117	69	8.0	8.0	NUM
admet-36	117	70	b	b	SYM
admet-36	117	71	108	108	NUM
admet-36	117	72	nitrofurantoin	nitrofurantoin	NOUN
admet-36	117	73	3.1	3.1	NUM
admet-36	117	74	3.1	3.1	NUM
admet-36	117	75	3.3	3.3	NUM
admet-36	117	76	0.2	0.2	NUM
admet-36	117	77	-0.1	-0.1	PROPN
admet-36	117	78	3.4	3.4	NUM
admet-36	117	79	269.3	269.3	NUM
admet-36	117	80	14.2	14.2	NUM
admet-36	117	81	ah	ah	INTJ
admet-36	117	82	120	120	NUM
admet-36	117	83	carbamazepine	carbamazepine	NOUN
admet-36	117	84	3.1	3.1	NUM
admet-36	117	85	3.1	3.1	NUM
admet-36	117	86	3.1	3.1	NUM
admet-36	117	87	0.0	0.0	NUM
admet-36	117	88	1.7	1.7	NUM
admet-36	117	89	1.4	1.4	NUM
admet-36	117	90	190.1	190.1	NUM
admet-36	117	91	25.5	25.5	NUM
admet-36	117	92	0	0	NUM
admet-36	117	93	46	46	NUM
admet-36	117	94	compound	compound	NOUN
admet-36	117	95	cpd1	cpd1	NOUN
admet-36	117	96	.	.	PUNCT
admet-36	118	1	the	the	DET
admet-36	118	2	compound	compound	NOUN
admet-36	118	3	is	be	AUX
admet-36	118	4	a	a	DET
admet-36	118	5	base	base	NOUN
admet-36	118	6	with	with	ADP
admet-36	118	7	an	an	DET
admet-36	118	8	experimentally	experimentally	ADV
admet-36	118	9	determined	determine	VERB
admet-36	118	10	log	log	NOUN
admet-36	118	11	p	p	NOUN
admet-36	118	12	value	value	NOUN
admet-36	118	13	of	of	ADP
admet-36	118	14	3.8	3.8	NUM
admet-36	118	15	.	.	PUNCT
admet-36	119	1	melting	melt	VERB
admet-36	119	2	point	point	NOUN
admet-36	119	3	determination	determination	NOUN
admet-36	119	4	by	by	ADP
admet-36	119	5	dsc	dsc	NOUN
admet-36	119	6	revealed	reveal	VERB
admet-36	119	7	a	a	DET
admet-36	119	8	rather	rather	ADV
admet-36	119	9	low	low	ADJ
admet-36	119	10	melting	melting	NOUN
admet-36	119	11	temperature	temperature	NOUN
admet-36	119	12	of	of	ADP
admet-36	119	13	97.1	97.1	NUM
admet-36	119	14	°	°	NOUN
admet-36	119	15	c	c	NOUN
admet-36	119	16	.	.	PUNCT
admet-36	120	1	measured	measure	VERB
admet-36	120	2	and	and	CCONJ
admet-36	120	3	extrapolated	extrapolate	VERB
admet-36	120	4	solubility	solubility	NOUN
admet-36	120	5	are	be	AUX
admet-36	120	6	in	in	ADP
admet-36	120	7	agreement	agreement	NOUN
admet-36	120	8	,	,	PUNCT
admet-36	120	9	the	the	DET
admet-36	120	10	fraction	fraction	NOUN
admet-36	120	11	ionized	ionize	VERB
admet-36	120	12	for	for	ADP
admet-36	120	13	this	this	DET
admet-36	120	14	compound	compound	NOUN
admet-36	120	15	is	be	AUX
admet-36	120	16	0.67	0.67	NUM
admet-36	120	17	.	.	PUNCT
admet-36	121	1	solubility	solubility	NOUN
admet-36	121	2	diagnosis	diagnosis	NOUN
admet-36	121	3	for	for	ADP
admet-36	121	4	this	this	DET
admet-36	121	5	compound	compound	NOUN
admet-36	121	6	reveals	reveal	VERB
admet-36	121	7	that	that	SCONJ
admet-36	121	8	solubility	solubility	NOUN
admet-36	121	9	is	be	AUX
admet-36	121	10	mainly	mainly	ADV
admet-36	121	11	limited	limit	VERB
admet-36	121	12	by	by	ADP
admet-36	121	13	lipophilicity	lipophilicity	NOUN
admet-36	121	14	,	,	PUNCT
admet-36	121	15	as	as	SCONJ
admet-36	121	16	ls	ls	NOUN
admet-36	121	17	is	be	AUX
admet-36	121	18	far	far	ADV
admet-36	121	19	below	below	ADP
admet-36	121	20	2	2	NUM
admet-36	121	21	and	and	CCONJ
admet-36	121	22	melting	melt	VERB
admet-36	121	23	temperature	temperature	NOUN
admet-36	121	24	below	below	ADP
admet-36	121	25	200	200	NUM
admet-36	121	26	°	°	NOUN
admet-36	121	27	c	c	NOUN
admet-36	121	28	.	.	PUNCT
admet-36	122	1	the	the	DET
admet-36	122	2	impact	impact	NOUN
admet-36	122	3	of	of	ADP
admet-36	122	4	the	the	DET
admet-36	122	5	hydrate	hydrate	NOUN
admet-36	122	6	to	to	ADP
admet-36	122	7	solubility	solubility	NOUN
admet-36	122	8	limitation	limitation	NOUN
admet-36	122	9	is	be	AUX
admet-36	122	10	therefore	therefore	ADV
admet-36	122	11	not	not	PART
admet-36	122	12	obvious	obvious	ADJ
admet-36	122	13	.	.	PUNCT
admet-36	123	1	compound	compound	NOUN
admet-36	123	2	cpd2	cpd2	PROPN
admet-36	123	3	.	.	PUNCT
admet-36	124	1	this	this	DET
admet-36	124	2	compound	compound	NOUN
admet-36	124	3	is	be	AUX
admet-36	124	4	practically	practically	ADV
admet-36	124	5	not	not	PART
admet-36	124	6	ionized	ionize	VERB
admet-36	124	7	at	at	ADP
admet-36	124	8	ph	ph	ADJ
admet-36	124	9	6.8	6.8	NUM
admet-36	124	10	,	,	PUNCT
admet-36	124	11	its	its	PRON
admet-36	124	12	extrapolated	extrapolated	ADJ
admet-36	124	13	solubility	solubility	NOUN
admet-36	124	14	is	be	AUX
admet-36	124	15	ten	ten	NUM
admet-36	124	16	times	time	NOUN
admet-36	124	17	higher	high	ADJ
admet-36	124	18	than	than	ADP
admet-36	124	19	the	the	DET
admet-36	124	20	value	value	NOUN
admet-36	124	21	determined	determine	VERB
admet-36	124	22	by	by	ADP
admet-36	124	23	the	the	DET
admet-36	124	24	shake	shake	NOUN
admet-36	124	25	flask	flask	NOUN
admet-36	124	26	method	method	NOUN
admet-36	124	27	.	.	PUNCT
admet-36	125	1	it	it	PRON
admet-36	125	2	’s	’	VERB
admet-36	125	3	a	a	DET
admet-36	125	4	zwitterion	zwitterion	NOUN
admet-36	125	5	with	with	ADP
admet-36	125	6	a	a	DET
admet-36	125	7	log	log	NOUN
admet-36	125	8	p	p	NOUN
admet-36	125	9	of	of	ADP
admet-36	125	10	5.0	5.0	NUM
admet-36	125	11	and	and	CCONJ
admet-36	125	12	the	the	DET
admet-36	125	13	sl	sl	ADJ
admet-36	125	14	value	value	NOUN
admet-36	125	15	reveals	reveal	VERB
admet-36	125	16	additional	additional	ADJ
admet-36	125	17	solubility	solubility	NOUN
admet-36	125	18	limitation	limitation	NOUN
admet-36	125	19	by	by	ADP
admet-36	125	20	roughly	roughly	ADV
admet-36	125	21	1	1	NUM
admet-36	125	22	logarithmic	logarithmic	ADJ
admet-36	125	23	unit	unit	NOUN
admet-36	125	24	.	.	PUNCT
admet-36	126	1	however	however	ADV
admet-36	126	2	,	,	PUNCT
admet-36	126	3	the	the	DET
admet-36	126	4	melting	melting	NOUN
admet-36	126	5	point	point	NOUN
admet-36	126	6	above	above	ADP
admet-36	126	7	200	200	NUM
admet-36	126	8	°	°	NOUN
admet-36	126	9	c	c	NOUN
admet-36	126	10	can	can	AUX
admet-36	126	11	be	be	AUX
admet-36	126	12	regarded	regard	VERB
admet-36	126	13	as	as	ADP
admet-36	126	14	strong	strong	ADJ
admet-36	126	15	indicator	indicator	NOUN
admet-36	126	16	for	for	ADP
admet-36	126	17	solubility	solubility	NOUN
admet-36	126	18	limitation	limitation	NOUN
admet-36	126	19	by	by	ADP
admet-36	126	20	crystal	crystal	PROPN
admet-36	126	21	lattice	lattice	PROPN
admet-36	126	22	forces	force	NOUN
admet-36	126	23	.	.	PUNCT
admet-36	127	1	compound	compound	NOUN
admet-36	127	2	cpd3	cpd3	PROPN
admet-36	127	3	.	.	PUNCT
admet-36	128	1	in	in	ADP
admet-36	128	2	this	this	DET
admet-36	128	3	example	example	NOUN
admet-36	128	4	,	,	PUNCT
admet-36	128	5	an	an	DET
admet-36	128	6	acidic	acidic	ADJ
admet-36	128	7	compound	compound	NOUN
admet-36	128	8	was	be	AUX
admet-36	128	9	investigated	investigate	VERB
admet-36	128	10	.	.	PUNCT
admet-36	129	1	again	again	ADV
admet-36	129	2	,	,	PUNCT
admet-36	129	3	low	low	ADJ
admet-36	129	4	sl	sl	ADJ
admet-36	129	5	and	and	CCONJ
admet-36	129	6	low	low	ADJ
admet-36	129	7	melting	melting	NOUN
admet-36	129	8	temperature	temperature	NOUN
admet-36	129	9	indicate	indicate	VERB
admet-36	129	10	no	no	DET
admet-36	129	11	significant	significant	ADJ
admet-36	129	12	solubility	solubility	NOUN
admet-36	129	13	limitation	limitation	NOUN
admet-36	129	14	by	by	ADP
admet-36	129	15	solid	solid	ADJ
admet-36	129	16	-	-	PUNCT
admet-36	129	17	state	state	NOUN
admet-36	129	18	contributions	contribution	NOUN
admet-36	129	19	.	.	PUNCT
admet-36	130	1	compound	compound	NOUN
admet-36	130	2	cpd4	cpd4	PROPN
admet-36	130	3	.	.	PUNCT
admet-36	131	1	in	in	ADP
admet-36	131	2	this	this	DET
admet-36	131	3	case	case	NOUN
admet-36	131	4	,	,	PUNCT
admet-36	131	5	the	the	DET
admet-36	131	6	compound	compound	NOUN
admet-36	131	7	is	be	AUX
admet-36	131	8	not	not	PART
admet-36	131	9	ionized	ionize	VERB
admet-36	131	10	,	,	PUNCT
admet-36	131	11	but	but	CCONJ
admet-36	131	12	it	it	PRON
admet-36	131	13	is	be	AUX
admet-36	131	14	rather	rather	ADV
admet-36	131	15	insoluble	insoluble	ADJ
admet-36	131	16	.	.	PUNCT
admet-36	132	1	a	a	DET
admet-36	132	2	quite	quite	ADV
admet-36	132	3	high	high	ADJ
admet-36	132	4	sl	sl	NOUN
admet-36	132	5	of	of	ADP
admet-36	132	6	3.0	3.0	NUM
admet-36	132	7	indicates	indicate	VERB
admet-36	132	8	a	a	DET
admet-36	132	9	thousand	thousand	NUM
admet-36	132	10	times	time	NOUN
admet-36	132	11	lower	low	ADJ
admet-36	132	12	solubility	solubility	NOUN
admet-36	132	13	than	than	ADP
admet-36	132	14	what	what	PRON
admet-36	132	15	could	could	AUX
admet-36	132	16	be	be	AUX
admet-36	132	17	expected	expect	VERB
admet-36	132	18	based	base	VERB
admet-36	132	19	on	on	ADP
admet-36	132	20	its	its	PRON
admet-36	132	21	lipophilicity	lipophilicity	NOUN
admet-36	132	22	(	(	PUNCT
admet-36	132	23	log	log	VERB
admet-36	132	24	p	p	PROPN
admet-36	132	25	3.1	3.1	NUM
admet-36	132	26	)	)	PUNCT
admet-36	132	27	.	.	PUNCT
admet-36	133	1	again	again	ADV
admet-36	133	2	,	,	PUNCT
admet-36	133	3	the	the	DET
admet-36	133	4	melting	melt	VERB
admet-36	133	5	temperature	temperature	NOUN
admet-36	133	6	of	of	ADP
admet-36	133	7	133.6	133.6	NUM
admet-36	133	8	°	°	NOUN
admet-36	133	9	c	c	NOUN
admet-36	133	10	does	do	AUX
admet-36	133	11	not	not	PART
admet-36	133	12	indicate	indicate	VERB
admet-36	133	13	a	a	DET
admet-36	133	14	strong	strong	ADJ
admet-36	133	15	crystal	crystal	NOUN
admet-36	133	16	lattice	lattice	PROPN
admet-36	133	17	contribution	contribution	NOUN
admet-36	133	18	.	.	PUNCT
admet-36	134	1	nitrofurantoin	nitrofurantoin	PROPN
admet-36	134	2	.	.	PUNCT
admet-36	135	1	solubility	solubility	NOUN
admet-36	135	2	of	of	ADP
admet-36	135	3	this	this	DET
admet-36	135	4	compound	compound	NOUN
admet-36	135	5	appears	appear	VERB
admet-36	135	6	to	to	PART
admet-36	135	7	be	be	AUX
admet-36	135	8	controlled	control	VERB
admet-36	135	9	mainly	mainly	ADV
admet-36	135	10	by	by	ADP
admet-36	135	11	other	other	ADJ
admet-36	135	12	factors	factor	NOUN
admet-36	135	13	than	than	ADP
admet-36	135	14	lipophilicity	lipophilicity	NOUN
admet-36	135	15	.	.	PUNCT
admet-36	136	1	the	the	DET
admet-36	136	2	compound	compound	NOUN
admet-36	136	3	is	be	AUX
admet-36	136	4	characterized	characterize	VERB
admet-36	136	5	by	by	ADP
admet-36	136	6	a	a	DET
admet-36	136	7	log	log	NOUN
admet-36	136	8	p	p	NOUN
admet-36	136	9	of	of	ADP
admet-36	136	10	-0.1	-0.1	PROPN
admet-36	136	11	and	and	CCONJ
admet-36	136	12	a	a	DET
admet-36	136	13	quite	quite	ADV
admet-36	136	14	high	high	ADJ
admet-36	136	15	melting	melting	NOUN
admet-36	136	16	temperature	temperature	NOUN
admet-36	136	17	around	around	ADP
admet-36	136	18	269	269	NUM
admet-36	136	19	°	°	NOUN
admet-36	136	20	c	c	NOUN
admet-36	136	21	.	.	PUNCT
admet-36	137	1	carbamazepine	carbamazepine	NOUN
admet-36	137	2	.	.	PUNCT
admet-36	138	1	carbamazepine	carbamazepine	NOUN
admet-36	138	2	is	be	AUX
admet-36	138	3	not	not	PART
admet-36	138	4	ionized	ionize	VERB
admet-36	138	5	at	at	ADP
admet-36	138	6	ph	ph	ADJ
admet-36	138	7	6.8	6.8	NUM
admet-36	138	8	,	,	PUNCT
admet-36	138	9	the	the	DET
admet-36	138	10	compound	compound	NOUN
admet-36	138	11	is	be	AUX
admet-36	138	12	not	not	PART
admet-36	138	13	very	very	ADV
admet-36	138	14	lipophilic	lipophilic	ADJ
admet-36	138	15	,	,	PUNCT
admet-36	138	16	as	as	ADP
admet-36	138	17	its	its	PRON
admet-36	138	18	log	log	NOUN
admet-36	138	19	p	p	NOUN
admet-36	138	20	of	of	ADP
admet-36	138	21	1.7	1.7	NUM
admet-36	138	22	suggests	suggest	NOUN
admet-36	138	23	.	.	PUNCT
admet-36	139	1	neither	neither	CCONJ
admet-36	139	2	the	the	DET
admet-36	139	3	sl	sl	ADJ
admet-36	139	4	parameter	parameter	NOUN
admet-36	139	5	of	of	ADP
admet-36	139	6	1.0	1.0	NUM
admet-36	139	7	nor	nor	CCONJ
admet-36	139	8	the	the	DET
admet-36	139	9	melting	melting	NOUN
admet-36	139	10	point	point	NOUN
admet-36	139	11	at	at	ADP
admet-36	139	12	190	190	NUM
admet-36	139	13	°	°	NOUN
admet-36	139	14	c	c	NOUN
admet-36	139	15	necessarily	necessarily	ADV
admet-36	139	16	indicate	indicate	VERB
admet-36	139	17	a	a	DET
admet-36	139	18	significant	significant	ADJ
admet-36	139	19	solid	solid	ADJ
admet-36	139	20	-	-	PUNCT
admet-36	139	21	state	state	NOUN
admet-36	139	22	contribution	contribution	NOUN
admet-36	139	23	to	to	ADP
admet-36	139	24	solubility	solubility	NOUN
admet-36	139	25	limitation	limitation	NOUN
admet-36	139	26	.	.	PUNCT
admet-36	140	1	overall	overall	ADJ
admet-36	140	2	,	,	PUNCT
admet-36	140	3	within	within	ADP
admet-36	140	4	the	the	DET
admet-36	140	5	solubility	solubility	NOUN
admet-36	140	6	diagnosis	diagnosis	NOUN
admet-36	140	7	parameter	parameter	NOUN
admet-36	140	8	set	set	NOUN
admet-36	140	9	,	,	PUNCT
admet-36	140	10	there	there	PRON
admet-36	140	11	is	be	VERB
admet-36	140	12	no	no	DET
admet-36	140	13	direct	direct	ADJ
admet-36	140	14	investigation	investigation	NOUN
admet-36	140	15	of	of	ADP
admet-36	140	16	the	the	DET
admet-36	140	17	nature	nature	NOUN
admet-36	140	18	of	of	ADP
admet-36	140	19	the	the	DET
admet-36	140	20	solid	solid	ADJ
admet-36	140	21	state	state	NOUN
admet-36	140	22	.	.	PUNCT
admet-36	141	1	if	if	SCONJ
admet-36	141	2	a	a	DET
admet-36	141	3	compound	compound	NOUN
admet-36	141	4	has	have	AUX
admet-36	141	5	been	be	AUX
admet-36	141	6	received	receive	VERB
admet-36	141	7	in	in	ADP
admet-36	141	8	the	the	DET
admet-36	141	9	laboratory	laboratory	NOUN
admet-36	141	10	as	as	ADP
admet-36	141	11	hydrated	hydrated	ADJ
admet-36	141	12	or	or	CCONJ
admet-36	141	13	generally	generally	ADV
admet-36	141	14	solvated	solvate	VERB
admet-36	141	15	form	form	NOUN
admet-36	141	16	,	,	PUNCT
admet-36	141	17	one	one	NUM
admet-36	141	18	admet	admet	NOUN
admet-36	141	19	&	&	CCONJ
admet-36	141	20	dmpk	dmpk	PROPN
admet-36	141	21	2(2	2(2	NUM
admet-36	141	22	)	)	PUNCT
admet-36	141	23	(	(	PUNCT
admet-36	141	24	2014	2014	NUM
admet-36	141	25	)	)	PUNCT
admet-36	141	26	115	115	NUM
admet-36	141	27	-	-	SYM
admet-36	141	28	125	125	NUM
admet-36	141	29	diagnosing	diagnosing	NOUN
admet-36	141	30	solubility	solubility	NOUN
admet-36	141	31	limitations	limitation	NOUN
admet-36	141	32	doi	doi	NOUN
admet-36	141	33	:	:	PUNCT
admet-36	141	34	10.5599	10.5599	NUM
admet-36	141	35	/	/	SYM
admet-36	141	36	admet.2.2.36	admet.2.2.36	NOUN
admet-36	141	37	121	121	NUM
admet-36	141	38	may	may	AUX
admet-36	141	39	realize	realize	VERB
admet-36	141	40	from	from	ADP
admet-36	141	41	dsc	dsc	PROPN
admet-36	141	42	measurement	measurement	NOUN
admet-36	141	43	that	that	SCONJ
admet-36	141	44	solvent	solvent	ADJ
admet-36	141	45	evaporation	evaporation	NOUN
admet-36	141	46	has	have	AUX
admet-36	141	47	taken	take	VERB
admet-36	141	48	place	place	NOUN
admet-36	141	49	or	or	CCONJ
admet-36	141	50	other	other	ADJ
admet-36	141	51	solid	solid	ADJ
admet-36	141	52	form	form	NOUN
admet-36	141	53	changes	change	NOUN
admet-36	141	54	have	have	AUX
admet-36	141	55	most	most	ADV
admet-36	141	56	likely	likely	ADV
admet-36	141	57	occurred	occur	VERB
admet-36	141	58	.	.	PUNCT
admet-36	142	1	more	more	ADV
admet-36	142	2	difficult	difficult	ADJ
admet-36	142	3	to	to	PART
admet-36	142	4	judge	judge	VERB
admet-36	142	5	,	,	PUNCT
admet-36	142	6	however	however	ADV
admet-36	142	7	,	,	PUNCT
admet-36	142	8	is	be	AUX
admet-36	142	9	a	a	DET
admet-36	142	10	potential	potential	ADJ
admet-36	142	11	solid	solid	ADJ
admet-36	142	12	form	form	NOUN
admet-36	142	13	change	change	NOUN
admet-36	142	14	during	during	ADP
admet-36	142	15	equilibration	equilibration	NOUN
admet-36	142	16	in	in	ADP
admet-36	142	17	aqueous	aqueous	ADJ
admet-36	142	18	environment	environment	NOUN
admet-36	142	19	.	.	PUNCT
admet-36	143	1	if	if	SCONJ
admet-36	143	2	compounds	compound	NOUN
admet-36	143	3	arrive	arrive	VERB
admet-36	143	4	for	for	ADP
admet-36	143	5	solubility	solubility	NOUN
admet-36	143	6	diagnosis	diagnosis	NOUN
admet-36	143	7	in	in	ADP
admet-36	143	8	anhydrated	anhydrate	VERB
admet-36	143	9	form	form	NOUN
admet-36	143	10	,	,	PUNCT
admet-36	143	11	characterization	characterization	NOUN
admet-36	143	12	of	of	ADP
admet-36	143	13	solid	solid	ADJ
admet-36	143	14	form	form	NOUN
admet-36	143	15	after	after	ADP
admet-36	143	16	equilibration	equilibration	NOUN
admet-36	143	17	would	would	AUX
admet-36	143	18	be	be	AUX
admet-36	143	19	necessary	necessary	ADJ
admet-36	143	20	to	to	PART
admet-36	143	21	identify	identify	VERB
admet-36	143	22	changes	change	NOUN
admet-36	143	23	in	in	ADP
admet-36	143	24	solid	solid	ADJ
admet-36	143	25	state	state	NOUN
admet-36	143	26	.	.	PUNCT
admet-36	144	1	given	give	VERB
admet-36	144	2	the	the	DET
admet-36	144	3	amount	amount	NOUN
admet-36	144	4	of	of	ADP
admet-36	144	5	material	material	NOUN
admet-36	144	6	and	and	CCONJ
admet-36	144	7	the	the	DET
admet-36	144	8	technology	technology	NOUN
admet-36	144	9	needed	need	VERB
admet-36	144	10	,	,	PUNCT
admet-36	144	11	such	such	ADJ
admet-36	144	12	investigations	investigation	NOUN
admet-36	144	13	are	be	AUX
admet-36	144	14	far	far	ADV
admet-36	144	15	beyond	beyond	ADP
admet-36	144	16	the	the	DET
admet-36	144	17	scope	scope	NOUN
admet-36	144	18	of	of	ADP
admet-36	144	19	lead	lead	ADJ
admet-36	144	20	optimization	optimization	NOUN
admet-36	144	21	activities	activity	NOUN
admet-36	144	22	.	.	PUNCT
admet-36	145	1	additionally	additionally	ADV
admet-36	145	2	,	,	PUNCT
admet-36	145	3	salts	salt	NOUN
admet-36	145	4	from	from	ADP
admet-36	145	5	the	the	DET
admet-36	145	6	buffer	buffer	NOUN
admet-36	145	7	solutions	solution	NOUN
admet-36	145	8	complicate	complicate	VERB
admet-36	145	9	solid	solid	ADJ
admet-36	145	10	form	form	NOUN
admet-36	145	11	investigations	investigation	NOUN
admet-36	145	12	after	after	ADP
admet-36	145	13	equilibration	equilibration	NOUN
admet-36	145	14	experiments	experiment	NOUN
admet-36	145	15	.	.	PUNCT
admet-36	146	1	therefore	therefore	ADV
admet-36	146	2	,	,	PUNCT
admet-36	146	3	it	it	PRON
admet-36	146	4	would	would	AUX
admet-36	146	5	be	be	AUX
admet-36	146	6	desirable	desirable	ADJ
admet-36	146	7	to	to	PART
admet-36	146	8	classify	classify	VERB
admet-36	146	9	compounds	compound	NOUN
admet-36	146	10	for	for	ADP
admet-36	146	11	their	their	PRON
admet-36	146	12	possibility	possibility	NOUN
admet-36	146	13	of	of	ADP
admet-36	146	14	hydrate	hydrate	ADJ
admet-36	146	15	formation	formation	NOUN
admet-36	146	16	by	by	ADP
admet-36	146	17	other	other	ADJ
admet-36	146	18	means	mean	NOUN
admet-36	146	19	that	that	PRON
admet-36	146	20	require	require	VERB
admet-36	146	21	less	less	ADJ
admet-36	146	22	experimental	experimental	ADJ
admet-36	146	23	effort	effort	NOUN
admet-36	146	24	,	,	PUNCT
admet-36	146	25	in	in	ADP
admet-36	146	26	order	order	NOUN
admet-36	146	27	to	to	PART
admet-36	146	28	cope	cope	VERB
admet-36	146	29	with	with	ADP
admet-36	146	30	the	the	DET
admet-36	146	31	time	time	NOUN
admet-36	146	32	and	and	CCONJ
admet-36	146	33	material	material	NOUN
admet-36	146	34	constrains	constrain	NOUN
admet-36	146	35	during	during	ADP
admet-36	146	36	compound	compound	NOUN
admet-36	146	37	optimization	optimization	NOUN
admet-36	146	38	phase	phase	NOUN
admet-36	146	39	.	.	PUNCT
admet-36	147	1	ideally	ideally	ADV
admet-36	147	2	,	,	PUNCT
admet-36	147	3	structure	structure	NOUN
admet-36	147	4	based	base	VERB
admet-36	147	5	chemical	chemical	NOUN
admet-36	147	6	descriptors	descriptor	NOUN
admet-36	147	7	would	would	AUX
admet-36	147	8	allow	allow	VERB
admet-36	147	9	at	at	ADP
admet-36	147	10	least	least	ADJ
admet-36	147	11	to	to	PART
admet-36	147	12	point	point	VERB
admet-36	147	13	out	out	ADP
admet-36	147	14	to	to	ADP
admet-36	147	15	a	a	DET
admet-36	147	16	certain	certain	ADJ
admet-36	147	17	possibility	possibility	NOUN
admet-36	147	18	of	of	ADP
admet-36	147	19	hydrate	hydrate	ADJ
admet-36	147	20	formation	formation	NOUN
admet-36	147	21	.	.	PUNCT
admet-36	148	1	according	accord	VERB
admet-36	148	2	to	to	ADP
admet-36	148	3	infantes	infantes	PROPN
admet-36	148	4	et	et	PROPN
admet-36	148	5	al	al	PROPN
admet-36	148	6	.	.	PUNCT
admet-36	149	1	[	[	X
admet-36	149	2	18	18	NUM
admet-36	149	3	]	]	PUNCT
admet-36	149	4	,	,	PUNCT
admet-36	149	5	the	the	DET
admet-36	149	6	probability	probability	NOUN
admet-36	149	7	of	of	ADP
admet-36	149	8	hydrate	hydrate	ADJ
admet-36	149	9	formation	formation	NOUN
admet-36	149	10	is	be	AUX
admet-36	149	11	not	not	PART
admet-36	149	12	correlated	correlate	VERB
admet-36	149	13	to	to	ADP
admet-36	149	14	the	the	DET
admet-36	149	15	ratio	ratio	NOUN
admet-36	149	16	of	of	ADP
admet-36	149	17	hbond	hbond	ADJ
admet-36	149	18	donors	donor	NOUN
admet-36	149	19	to	to	ADP
admet-36	149	20	acceptors	acceptor	NOUN
admet-36	149	21	,	,	PUNCT
admet-36	149	22	but	but	CCONJ
admet-36	149	23	to	to	ADP
admet-36	149	24	the	the	DET
admet-36	149	25	sum	sum	NOUN
admet-36	149	26	thereof	thereof	ADV
admet-36	149	27	.	.	PUNCT
admet-36	150	1	as	as	SCONJ
admet-36	150	2	the	the	DET
admet-36	150	3	sum	sum	NOUN
admet-36	150	4	of	of	ADP
admet-36	150	5	h	h	NOUN
admet-36	150	6	-	-	PUNCT
admet-36	150	7	bond	bond	NOUN
admet-36	150	8	donors	donor	NOUN
admet-36	150	9	and	and	CCONJ
admet-36	150	10	acceptors	acceptor	NOUN
admet-36	150	11	is	be	AUX
admet-36	150	12	highly	highly	ADV
admet-36	150	13	correlated	correlate	VERB
admet-36	150	14	to	to	ADP
admet-36	150	15	the	the	DET
admet-36	150	16	psa	psa	NOUN
admet-36	150	17	,	,	PUNCT
admet-36	150	18	the	the	DET
admet-36	150	19	frequency	frequency	NOUN
admet-36	150	20	of	of	ADP
admet-36	150	21	hydrate	hydrate	ADJ
admet-36	150	22	formation	formation	NOUN
admet-36	150	23	is	be	AUX
admet-36	150	24	found	find	VERB
admet-36	150	25	to	to	PART
admet-36	150	26	increase	increase	VERB
admet-36	150	27	with	with	ADP
admet-36	150	28	psa	psa	NOUN
admet-36	150	29	,	,	PUNCT
admet-36	150	30	too	too	ADV
admet-36	150	31	.	.	PUNCT
admet-36	151	1	in	in	ADP
admet-36	151	2	order	order	NOUN
admet-36	151	3	to	to	PART
admet-36	151	4	review	review	VERB
admet-36	151	5	the	the	DET
admet-36	151	6	contributions	contribution	NOUN
admet-36	151	7	that	that	PRON
admet-36	151	8	h	h	NOUN
admet-36	151	9	-	-	PUNCT
admet-36	151	10	bond	bond	NOUN
admet-36	151	11	donors	donor	NOUN
admet-36	151	12	and	and	CCONJ
admet-36	151	13	acceptors	acceptor	NOUN
admet-36	151	14	provide	provide	VERB
admet-36	151	15	to	to	PART
admet-36	151	16	classify	classify	VERB
admet-36	151	17	compounds	compound	NOUN
admet-36	151	18	during	during	ADP
admet-36	151	19	the	the	DET
admet-36	151	20	lead	lead	ADJ
admet-36	151	21	optimization	optimization	NOUN
admet-36	151	22	process	process	NOUN
admet-36	151	23	without	without	ADP
admet-36	151	24	detailed	detailed	ADJ
admet-36	151	25	analysis	analysis	NOUN
admet-36	151	26	of	of	ADP
admet-36	151	27	solid	solid	ADJ
admet-36	151	28	state	state	NOUN
admet-36	151	29	properties	property	NOUN
admet-36	151	30	,	,	PUNCT
admet-36	151	31	the	the	DET
admet-36	151	32	currently	currently	ADV
admet-36	151	33	available	available	ADJ
admet-36	151	34	in	in	ADP
admet-36	151	35	-	-	PUNCT
admet-36	151	36	house	house	NOUN
admet-36	151	37	dataset	dataset	NOUN
admet-36	151	38	of	of	ADP
admet-36	151	39	solubility	solubility	NOUN
admet-36	151	40	diagnosis	diagnosis	NOUN
admet-36	151	41	was	be	AUX
admet-36	151	42	analyzed	analyze	VERB
admet-36	151	43	.	.	PUNCT
admet-36	152	1	it	it	PRON
admet-36	152	2	comprises	comprise	VERB
admet-36	152	3	about	about	ADP
admet-36	152	4	200	200	NUM
admet-36	152	5	proprietary	proprietary	ADJ
admet-36	152	6	compounds	compound	NOUN
admet-36	152	7	,	,	PUNCT
admet-36	152	8	for	for	ADP
admet-36	152	9	which	which	PRON
admet-36	152	10	the	the	DET
admet-36	152	11	number	number	NOUN
admet-36	152	12	of	of	ADP
admet-36	152	13	known	know	VERB
admet-36	152	14	hydrates	hydrate	NOUN
admet-36	152	15	has	have	AUX
admet-36	152	16	been	be	AUX
admet-36	152	17	counted	count	VERB
admet-36	152	18	.	.	PUNCT
admet-36	153	1	indeed	indeed	ADV
admet-36	153	2	,	,	PUNCT
admet-36	153	3	analysis	analysis	NOUN
admet-36	153	4	revealed	reveal	VERB
admet-36	153	5	that	that	SCONJ
admet-36	153	6	the	the	DET
admet-36	153	7	frequency	frequency	NOUN
admet-36	153	8	of	of	ADP
admet-36	153	9	hydrate	hydrate	ADJ
admet-36	153	10	formation	formation	NOUN
admet-36	153	11	increases	increase	VERB
admet-36	153	12	with	with	ADP
admet-36	153	13	increasing	increase	VERB
admet-36	153	14	sum	sum	NOUN
admet-36	153	15	of	of	ADP
admet-36	153	16	h	h	NOUN
admet-36	153	17	-	-	PUNCT
admet-36	153	18	bond	bond	NOUN
admet-36	153	19	donors	donor	NOUN
admet-36	153	20	and	and	CCONJ
admet-36	153	21	acceptors	acceptor	NOUN
admet-36	153	22	and	and	CCONJ
admet-36	153	23	thus	thus	ADV
admet-36	153	24	also	also	ADV
admet-36	153	25	with	with	ADP
admet-36	153	26	increasing	increase	VERB
admet-36	153	27	psa	psa	NOUN
admet-36	153	28	(	(	PUNCT
admet-36	153	29	see	see	VERB
admet-36	153	30	figure	figure	NOUN
admet-36	153	31	1	1	NUM
admet-36	153	32	)	)	PUNCT
admet-36	153	33	.	.	PUNCT
admet-36	154	1	the	the	DET
admet-36	154	2	results	result	NOUN
admet-36	154	3	are	be	AUX
admet-36	154	4	in	in	ADP
admet-36	154	5	accordance	accordance	NOUN
admet-36	154	6	with	with	ADP
admet-36	154	7	the	the	DET
admet-36	154	8	results	result	NOUN
admet-36	154	9	from	from	ADP
admet-36	154	10	infantes	infante	NOUN
admet-36	154	11	et	et	PROPN
admet-36	154	12	al	al	PROPN
admet-36	154	13	.	.	PUNCT
admet-36	155	1	[	[	X
admet-36	155	2	18	18	NUM
admet-36	155	3	]	]	PUNCT
admet-36	155	4	,	,	PUNCT
admet-36	155	5	and	and	CCONJ
admet-36	155	6	based	base	VERB
admet-36	155	7	on	on	ADP
admet-36	155	8	our	our	PRON
admet-36	155	9	analysis	analysis	NOUN
admet-36	155	10	,	,	PUNCT
admet-36	155	11	an	an	DET
admet-36	155	12	increasing	increase	VERB
admet-36	155	13	number	number	NOUN
admet-36	155	14	of	of	ADP
admet-36	155	15	hydrated	hydrated	ADJ
admet-36	155	16	compounds	compound	NOUN
admet-36	155	17	is	be	AUX
admet-36	155	18	found	find	VERB
admet-36	155	19	when	when	SCONJ
admet-36	155	20	the	the	DET
admet-36	155	21	sum	sum	NOUN
admet-36	155	22	of	of	ADP
admet-36	155	23	h	h	NOUN
admet-36	155	24	-	-	PUNCT
admet-36	155	25	bond	bond	NOUN
admet-36	155	26	donors	donor	NOUN
admet-36	155	27	and	and	CCONJ
admet-36	155	28	h	h	NOUN
admet-36	155	29	-	-	PUNCT
admet-36	155	30	bond	bond	NOUN
admet-36	155	31	acceptors	acceptor	NOUN
admet-36	155	32	is	be	AUX
admet-36	155	33	greater	great	ADJ
admet-36	155	34	than	than	ADP
admet-36	155	35	9	9	NUM
admet-36	155	36	.	.	PUNCT
admet-36	156	1	according	accord	VERB
admet-36	156	2	to	to	ADP
admet-36	156	3	our	our	PRON
admet-36	156	4	dataset	dataset	NOUN
admet-36	156	5	,	,	PUNCT
admet-36	156	6	nearly	nearly	ADV
admet-36	156	7	20	20	NUM
admet-36	156	8	%	%	NOUN
admet-36	156	9	of	of	ADP
admet-36	156	10	the	the	DET
admet-36	156	11	compounds	compound	NOUN
admet-36	156	12	with	with	ADP
admet-36	156	13	a	a	DET
admet-36	156	14	sum	sum	NOUN
admet-36	156	15	of	of	ADP
admet-36	156	16	10	10	NUM
admet-36	156	17	are	be	AUX
admet-36	156	18	found	find	VERB
admet-36	156	19	to	to	PART
admet-36	156	20	form	form	VERB
admet-36	156	21	hydrates	hydrate	NOUN
admet-36	156	22	.	.	PUNCT
admet-36	157	1	although	although	SCONJ
admet-36	157	2	in	in	ADP
admet-36	157	3	this	this	DET
admet-36	157	4	dataset	dataset	NOUN
admet-36	157	5	the	the	DET
admet-36	157	6	number	number	NOUN
admet-36	157	7	of	of	ADP
admet-36	157	8	compounds	compound	NOUN
admet-36	157	9	with	with	ADP
admet-36	157	10	a	a	DET
admet-36	157	11	sum	sum	NOUN
admet-36	157	12	of	of	ADP
admet-36	157	13	more	more	ADJ
admet-36	157	14	than	than	ADP
admet-36	157	15	11	11	NUM
admet-36	157	16	was	be	AUX
admet-36	157	17	rather	rather	ADV
admet-36	157	18	low	low	ADJ
admet-36	157	19	,	,	PUNCT
admet-36	157	20	the	the	DET
admet-36	157	21	frequency	frequency	NOUN
admet-36	157	22	distribution	distribution	NOUN
admet-36	157	23	as	as	ADP
admet-36	157	24	percentage	percentage	NOUN
admet-36	157	25	within	within	ADP
admet-36	157	26	the	the	DET
admet-36	157	27	respective	respective	ADJ
admet-36	157	28	binning	binning	NOUN
admet-36	157	29	showed	show	VERB
admet-36	157	30	a	a	DET
admet-36	157	31	steady	steady	ADJ
admet-36	157	32	increase	increase	NOUN
admet-36	157	33	with	with	ADP
admet-36	157	34	increasing	increase	VERB
admet-36	157	35	sum	sum	NOUN
admet-36	157	36	of	of	ADP
admet-36	157	37	donors	donor	NOUN
admet-36	157	38	and	and	CCONJ
admet-36	157	39	acceptors	acceptor	NOUN
admet-36	157	40	.	.	PUNCT
admet-36	158	1	however	however	ADV
admet-36	158	2	,	,	PUNCT
admet-36	158	3	the	the	DET
admet-36	158	4	total	total	ADJ
admet-36	158	5	number	number	NOUN
admet-36	158	6	of	of	ADP
admet-36	158	7	confirmed	confirm	VERB
admet-36	158	8	hydrates	hydrate	NOUN
admet-36	158	9	at	at	ADP
admet-36	158	10	this	this	DET
admet-36	158	11	stage	stage	NOUN
admet-36	158	12	of	of	ADP
admet-36	158	13	drug	drug	NOUN
admet-36	158	14	development	development	NOUN
admet-36	158	15	is	be	AUX
admet-36	158	16	limited	limited	ADJ
admet-36	158	17	,	,	PUNCT
admet-36	158	18	thus	thus	ADV
admet-36	158	19	the	the	DET
admet-36	158	20	absolute	absolute	ADJ
admet-36	158	21	frequency	frequency	NOUN
admet-36	158	22	of	of	ADP
admet-36	158	23	hydrate	hydrate	ADJ
admet-36	158	24	formation	formation	NOUN
admet-36	158	25	is	be	AUX
admet-36	158	26	likely	likely	ADJ
admet-36	158	27	to	to	PART
admet-36	158	28	be	be	AUX
admet-36	158	29	underestimated	underestimate	VERB
admet-36	158	30	.	.	PUNCT
admet-36	159	1	this	this	PRON
admet-36	159	2	may	may	AUX
admet-36	159	3	explain	explain	VERB
admet-36	159	4	why	why	SCONJ
admet-36	159	5	the	the	DET
admet-36	159	6	overall	overall	ADJ
admet-36	159	7	percentage	percentage	NOUN
admet-36	159	8	of	of	ADP
admet-36	159	9	hydrates	hydrate	NOUN
admet-36	159	10	in	in	ADP
admet-36	159	11	our	our	PRON
admet-36	159	12	proprietary	proprietary	ADJ
admet-36	159	13	dataset	dataset	NOUN
admet-36	159	14	is	be	AUX
admet-36	159	15	lower	low	ADJ
admet-36	159	16	as	as	SCONJ
admet-36	159	17	compared	compare	VERB
admet-36	159	18	to	to	ADP
admet-36	159	19	results	result	NOUN
admet-36	159	20	in	in	ADP
admet-36	159	21	reference	reference	NOUN
admet-36	159	22	[	[	X
admet-36	159	23	18	18	NUM
admet-36	159	24	]	]	PUNCT
admet-36	159	25	.	.	PUNCT
admet-36	160	1	what	what	PRON
admet-36	160	2	can	can	AUX
admet-36	160	3	we	we	PRON
admet-36	160	4	learn	learn	VERB
admet-36	160	5	from	from	ADP
admet-36	160	6	hydrates	hydrate	NOUN
admet-36	160	7	about	about	ADP
admet-36	160	8	solid	solid	ADJ
admet-36	160	9	state	state	NOUN
admet-36	160	10	contribution	contribution	NOUN
admet-36	160	11	to	to	ADP
admet-36	160	12	solubility	solubility	NOUN
admet-36	160	13	limitation	limitation	NOUN
admet-36	160	14	?	?	PUNCT
admet-36	161	1	since	since	SCONJ
admet-36	161	2	the	the	DET
admet-36	161	3	idea	idea	NOUN
admet-36	161	4	of	of	ADP
admet-36	161	5	solubility	solubility	NOUN
admet-36	161	6	diagnosis	diagnosis	NOUN
admet-36	161	7	is	be	AUX
admet-36	161	8	to	to	PART
admet-36	161	9	identify	identify	VERB
admet-36	161	10	the	the	DET
admet-36	161	11	main	main	ADJ
admet-36	161	12	factors	factor	NOUN
admet-36	161	13	that	that	PRON
admet-36	161	14	contribute	contribute	VERB
admet-36	161	15	to	to	ADP
admet-36	161	16	solubility	solubility	NOUN
admet-36	161	17	limitation	limitation	NOUN
admet-36	161	18	,	,	PUNCT
admet-36	161	19	the	the	DET
admet-36	161	20	in	in	ADP
admet-36	161	21	-	-	PUNCT
admet-36	161	22	house	house	NOUN
admet-36	161	23	dataset	dataset	NOUN
admet-36	161	24	was	be	AUX
admet-36	161	25	analyzed	analyze	VERB
admet-36	161	26	in	in	ADP
admet-36	161	27	regard	regard	NOUN
admet-36	161	28	of	of	ADP
admet-36	161	29	the	the	DET
admet-36	161	30	role	role	NOUN
admet-36	161	31	of	of	ADP
admet-36	161	32	psa	psa	NOUN
admet-36	161	33	for	for	ADP
admet-36	161	34	compounds	compound	NOUN
admet-36	161	35	that	that	PRON
admet-36	161	36	are	be	AUX
admet-36	161	37	either	either	ADV
admet-36	161	38	identified	identify	VERB
admet-36	161	39	as	as	ADP
admet-36	161	40	solubility	solubility	NOUN
admet-36	161	41	limited	limit	VERB
admet-36	161	42	by	by	ADP
admet-36	161	43	lipophilicity	lipophilicity	NOUN
admet-36	161	44	or	or	CCONJ
admet-36	161	45	by	by	ADP
admet-36	161	46	crystal	crystal	PROPN
admet-36	161	47	lattice	lattice	PROPN
admet-36	161	48	forces	force	NOUN
admet-36	161	49	.	.	PUNCT
admet-36	162	1	psa	psa	NOUN
admet-36	162	2	is	be	AUX
admet-36	162	3	preferred	prefer	VERB
admet-36	162	4	over	over	ADP
admet-36	162	5	the	the	DET
admet-36	162	6	sum	sum	NOUN
admet-36	162	7	of	of	ADP
admet-36	162	8	hbond	hbond	ADJ
admet-36	162	9	donors	donor	NOUN
admet-36	162	10	and	and	CCONJ
admet-36	162	11	acceptors	acceptor	NOUN
admet-36	162	12	since	since	SCONJ
admet-36	162	13	it	it	PRON
admet-36	162	14	can	can	AUX
admet-36	162	15	be	be	AUX
admet-36	162	16	easily	easily	ADV
admet-36	162	17	calculated	calculate	VERB
admet-36	162	18	as	as	ADP
admet-36	162	19	a	a	DET
admet-36	162	20	descriptor	descriptor	NOUN
admet-36	162	21	for	for	ADP
admet-36	162	22	qsar	qsar	NOUN
admet-36	162	23	modeling	modeling	NOUN
admet-36	162	24	.	.	PUNCT
admet-36	163	1	because	because	SCONJ
admet-36	163	2	an	an	DET
admet-36	163	3	increase	increase	NOUN
admet-36	163	4	of	of	ADP
admet-36	163	5	the	the	DET
admet-36	163	6	sum	sum	NOUN
admet-36	163	7	of	of	ADP
admet-36	163	8	h	h	NOUN
admet-36	163	9	-	-	PUNCT
admet-36	163	10	bond	bond	NOUN
admet-36	163	11	donors	donor	NOUN
admet-36	163	12	and	and	CCONJ
admet-36	163	13	acceptors	acceptor	NOUN
admet-36	163	14	,	,	PUNCT
admet-36	163	15	and	and	CCONJ
admet-36	163	16	thus	thus	ADV
admet-36	163	17	psa	psa	VERB
admet-36	163	18	,	,	PUNCT
admet-36	163	19	has	have	AUX
admet-36	163	20	been	be	AUX
admet-36	163	21	found	find	VERB
admet-36	163	22	to	to	PART
admet-36	163	23	lead	lead	VERB
admet-36	163	24	to	to	ADP
admet-36	163	25	a	a	DET
admet-36	163	26	higher	high	ADJ
admet-36	163	27	frequency	frequency	NOUN
admet-36	163	28	of	of	ADP
admet-36	163	29	hydrate	hydrate	ADJ
admet-36	163	30	formation	formation	NOUN
admet-36	163	31	,	,	PUNCT
admet-36	163	32	an	an	DET
admet-36	163	33	additional	additional	ADJ
admet-36	163	34	effect	effect	NOUN
admet-36	163	35	of	of	ADP
admet-36	163	36	solid	solid	ADJ
admet-36	163	37	-	-	PUNCT
admet-36	163	38	state	state	NOUN
admet-36	163	39	contribution	contribution	NOUN
admet-36	163	40	with	with	ADP
admet-36	163	41	increasing	increase	VERB
admet-36	163	42	polar	polar	ADJ
admet-36	163	43	interactions	interaction	NOUN
admet-36	163	44	could	could	AUX
admet-36	163	45	also	also	ADV
admet-36	163	46	be	be	AUX
admet-36	163	47	suspected	suspect	VERB
admet-36	163	48	.	.	PUNCT
admet-36	164	1	thus	thus	ADV
admet-36	164	2	,	,	PUNCT
admet-36	164	3	the	the	DET
admet-36	164	4	role	role	NOUN
admet-36	164	5	of	of	ADP
admet-36	164	6	polar	polar	ADJ
admet-36	164	7	interactions	interaction	NOUN
admet-36	164	8	on	on	ADP
admet-36	164	9	solubility	solubility	NOUN
admet-36	164	10	limiting	limit	VERB
admet-36	164	11	contributions	contribution	NOUN
admet-36	164	12	within	within	ADP
admet-36	164	13	our	our	PRON
admet-36	164	14	proprietary	proprietary	ADJ
admet-36	164	15	dataset	dataset	NOUN
admet-36	164	16	should	should	AUX
admet-36	164	17	be	be	AUX
admet-36	164	18	elucidated	elucidate	VERB
admet-36	164	19	.	.	PUNCT
admet-36	165	1	for	for	ADP
admet-36	165	2	this	this	PRON
admet-36	165	3	,	,	PUNCT
admet-36	165	4	compounds	compound	VERB
admet-36	165	5	that	that	PRON
admet-36	165	6	were	be	AUX
admet-36	165	7	classified	classify	VERB
admet-36	165	8	by	by	ADP
admet-36	165	9	solubility	solubility	NOUN
admet-36	165	10	diagnosis	diagnosis	NOUN
admet-36	165	11	as	as	ADP
admet-36	165	12	being	be	AUX
admet-36	165	13	mainly	mainly	ADV
admet-36	165	14	limited	limit	VERB
admet-36	165	15	by	by	ADP
admet-36	165	16	either	either	CCONJ
admet-36	165	17	lipophilicity	lipophilicity	NOUN
admet-36	165	18	or	or	CCONJ
admet-36	165	19	crystal	crystal	NOUN
admet-36	165	20	lattice	lattice	PROPN
admet-36	165	21	forces	force	NOUN
admet-36	165	22	have	have	AUX
admet-36	165	23	been	be	AUX
admet-36	165	24	analyzed	analyze	VERB
admet-36	165	25	with	with	ADP
admet-36	165	26	respect	respect	NOUN
admet-36	165	27	to	to	ADP
admet-36	165	28	their	their	PRON
admet-36	165	29	psa	psa	NOUN
admet-36	165	30	values	value	NOUN
admet-36	165	31	.	.	PUNCT
admet-36	166	1	berghausen	berghausen	NOUN
admet-36	166	2	and	and	CCONJ
admet-36	166	3	faller	faller	NOUN
admet-36	166	4	admet	admet	PROPN
admet-36	166	5	&	&	CCONJ
admet-36	166	6	dmpk	dmpk	PROPN
admet-36	166	7	2(2	2(2	NUM
admet-36	166	8	)	)	PUNCT
admet-36	166	9	(	(	PUNCT
admet-36	166	10	2014	2014	NUM
admet-36	166	11	)	)	PUNCT
admet-36	166	12	115	115	NUM
admet-36	166	13	-	-	SYM
admet-36	166	14	125	125	NUM
admet-36	166	15	122	122	NUM
admet-36	166	16	(	(	PUNCT
admet-36	166	17	b	b	NOUN
admet-36	166	18	)	)	PUNCT
admet-36	166	19	(	(	PUNCT
admet-36	166	20	a	a	DET
admet-36	166	21	)	)	PUNCT
admet-36	166	22	figure	figure	NOUN
admet-36	166	23	1	1	NUM
admet-36	166	24	.	.	PUNCT
admet-36	167	1	(	(	PUNCT
admet-36	167	2	a	a	DET
admet-36	167	3	)	)	PUNCT
admet-36	167	4	frequency	frequency	NOUN
admet-36	167	5	distribution	distribution	NOUN
admet-36	167	6	of	of	ADP
admet-36	167	7	hydrates	hydrate	NOUN
admet-36	167	8	vs	vs	ADP
admet-36	167	9	the	the	DET
admet-36	167	10	sum	sum	NOUN
admet-36	167	11	of	of	ADP
admet-36	167	12	h	h	NOUN
admet-36	167	13	-	-	PUNCT
admet-36	167	14	bond	bond	NOUN
admet-36	167	15	donor	donor	NOUN
admet-36	167	16	(	(	PUNCT
admet-36	167	17	hbd	hbd	PROPN
admet-36	167	18	)	)	PUNCT
admet-36	167	19	s	s	PROPN
admet-36	167	20	and	and	CCONJ
admet-36	167	21	h	h	NOUN
admet-36	167	22	-	-	PUNCT
admet-36	167	23	bond	bond	NOUN
admet-36	167	24	acceptors	acceptor	NOUN
admet-36	167	25	(	(	PUNCT
admet-36	167	26	hba	hba	NOUN
admet-36	167	27	)	)	PUNCT
admet-36	167	28	in	in	ADP
admet-36	167	29	the	the	DET
admet-36	167	30	proprietary	proprietary	ADJ
admet-36	167	31	solubility	solubility	NOUN
admet-36	167	32	diagnosis	diagnosis	NOUN
admet-36	167	33	dataset	dataset	NOUN
admet-36	167	34	;	;	PUNCT
admet-36	167	35	total	total	ADJ
admet-36	167	36	numbers	number	NOUN
admet-36	167	37	.	.	PUNCT
admet-36	168	1	(	(	PUNCT
admet-36	168	2	b	b	X
admet-36	168	3	)	)	PUNCT
admet-36	168	4	percentage	percentage	NOUN
admet-36	168	5	of	of	ADP
admet-36	168	6	confirmed	confirm	VERB
admet-36	168	7	hydrates	hydrate	NOUN
admet-36	168	8	within	within	ADP
admet-36	168	9	the	the	DET
admet-36	168	10	respective	respective	ADJ
admet-36	168	11	sum	sum	NOUN
admet-36	168	12	of	of	ADP
admet-36	168	13	h	h	NOUN
admet-36	168	14	-	-	PUNCT
admet-36	168	15	bond	bond	NOUN
admet-36	168	16	donors	donor	NOUN
admet-36	168	17	and	and	CCONJ
admet-36	168	18	acceptors	acceptor	NOUN
admet-36	168	19	.	.	PUNCT
admet-36	169	1	table	table	NOUN
admet-36	169	2	5	5	NUM
admet-36	169	3	summarizes	summarize	NOUN
admet-36	169	4	the	the	DET
admet-36	169	5	average	average	ADJ
admet-36	169	6	and	and	CCONJ
admet-36	169	7	median	median	ADJ
admet-36	169	8	values	value	NOUN
admet-36	169	9	of	of	ADP
admet-36	169	10	compounds	compound	NOUN
admet-36	169	11	from	from	ADP
admet-36	169	12	these	these	DET
admet-36	169	13	classes	class	NOUN
admet-36	169	14	.	.	PUNCT
admet-36	170	1	the	the	DET
admet-36	170	2	analysis	analysis	NOUN
admet-36	170	3	of	of	ADP
admet-36	170	4	both	both	CCONJ
admet-36	170	5	average	average	ADJ
admet-36	170	6	and	and	CCONJ
admet-36	170	7	median	median	ADJ
admet-36	170	8	psa	psa	NOUN
admet-36	170	9	values	value	NOUN
admet-36	170	10	strongly	strongly	ADV
admet-36	170	11	suggests	suggest	VERB
admet-36	170	12	that	that	SCONJ
admet-36	170	13	compounds	compound	VERB
admet-36	170	14	with	with	ADP
admet-36	170	15	a	a	DET
admet-36	170	16	significant	significant	ADJ
admet-36	170	17	crystal	crystal	NOUN
admet-36	170	18	lattice	lattice	NOUN
admet-36	170	19	contribution	contribution	NOUN
admet-36	170	20	to	to	ADP
admet-36	170	21	solubility	solubility	NOUN
admet-36	170	22	limitation	limitation	NOUN
admet-36	170	23	are	be	AUX
admet-36	170	24	characterized	characterize	VERB
admet-36	170	25	by	by	ADP
admet-36	170	26	a	a	DET
admet-36	170	27	higher	high	ADJ
admet-36	170	28	psa	psa	NOUN
admet-36	170	29	value	value	NOUN
admet-36	170	30	.	.	PUNCT
admet-36	171	1	as	as	SCONJ
admet-36	171	2	illustrated	illustrate	VERB
admet-36	171	3	by	by	ADP
admet-36	171	4	the	the	DET
admet-36	171	5	histogram	histogram	NOUN
admet-36	171	6	in	in	ADP
admet-36	171	7	figure	figure	NOUN
admet-36	171	8	2	2	NUM
admet-36	171	9	(	(	PUNCT
admet-36	171	10	a	a	NOUN
admet-36	171	11	)	)	PUNCT
admet-36	171	12	,	,	PUNCT
admet-36	171	13	the	the	DET
admet-36	171	14	majority	majority	NOUN
admet-36	171	15	of	of	ADP
admet-36	171	16	compounds	compound	NOUN
admet-36	171	17	that	that	PRON
admet-36	171	18	reveal	reveal	VERB
admet-36	171	19	a	a	DET
admet-36	171	20	significant	significant	ADJ
admet-36	171	21	crystal	crystal	NOUN
admet-36	171	22	lattice	lattice	NOUN
admet-36	171	23	contribution	contribution	NOUN
admet-36	171	24	to	to	ADP
admet-36	171	25	solubility	solubility	NOUN
admet-36	171	26	limitation	limitation	NOUN
admet-36	171	27	are	be	AUX
admet-36	171	28	characterized	characterize	VERB
admet-36	171	29	by	by	ADP
admet-36	171	30	a	a	DET
admet-36	171	31	psa	psa	NOUN
admet-36	171	32	of	of	ADP
admet-36	171	33	75	75	NUM
admet-36	171	34	å2	å2	NOUN
admet-36	171	35	or	or	CCONJ
admet-36	171	36	more	more	ADJ
admet-36	171	37	.	.	PUNCT
admet-36	172	1	in	in	ADP
admet-36	172	2	case	case	NOUN
admet-36	172	3	of	of	ADP
admet-36	172	4	compounds	compound	NOUN
admet-36	172	5	with	with	ADP
admet-36	172	6	lipophilicity	lipophilicity	NOUN
admet-36	172	7	being	be	AUX
admet-36	172	8	the	the	DET
admet-36	172	9	main	main	ADJ
admet-36	172	10	limiting	limiting	NOUN
admet-36	172	11	factor	factor	NOUN
admet-36	172	12	,	,	PUNCT
admet-36	172	13	this	this	DET
admet-36	172	14	distribution	distribution	NOUN
admet-36	172	15	is	be	AUX
admet-36	172	16	shifted	shift	VERB
admet-36	172	17	towards	towards	ADP
admet-36	172	18	lower	low	ADJ
admet-36	172	19	psa	psa	NOUN
admet-36	172	20	values	value	NOUN
admet-36	172	21	,	,	PUNCT
admet-36	172	22	see	see	VERB
admet-36	172	23	figure	figure	NOUN
admet-36	172	24	2	2	NUM
admet-36	172	25	(	(	PUNCT
admet-36	172	26	b	b	NOUN
admet-36	172	27	)	)	PUNCT
admet-36	172	28	.	.	PUNCT
admet-36	173	1	here	here	ADV
admet-36	173	2	,	,	PUNCT
admet-36	173	3	the	the	DET
admet-36	173	4	majority	majority	NOUN
admet-36	173	5	of	of	ADP
admet-36	173	6	compounds	compound	NOUN
admet-36	173	7	are	be	AUX
admet-36	173	8	characterized	characterize	VERB
admet-36	173	9	by	by	ADP
admet-36	173	10	a	a	DET
admet-36	173	11	psa	psa	NOUN
admet-36	173	12	of	of	ADP
admet-36	173	13	less	less	ADJ
admet-36	173	14	than	than	ADP
admet-36	173	15	75	75	NUM
admet-36	173	16	å2	å2	NOUN
admet-36	173	17	.	.	PUNCT
admet-36	174	1	notably	notably	ADV
admet-36	174	2	,	,	PUNCT
admet-36	174	3	only	only	ADV
admet-36	174	4	few	few	ADJ
admet-36	174	5	compounds	compound	NOUN
admet-36	174	6	in	in	ADP
admet-36	174	7	the	the	DET
admet-36	174	8	current	current	ADJ
admet-36	174	9	dataset	dataset	NOUN
admet-36	174	10	reveal	reveal	VERB
admet-36	174	11	a	a	DET
admet-36	174	12	psa	psa	NOUN
admet-36	174	13	of	of	ADP
admet-36	174	14	greater	great	ADJ
admet-36	174	15	than	than	ADP
admet-36	174	16	100	100	NUM
admet-36	174	17	å2	å2	NOUN
admet-36	174	18	in	in	ADP
admet-36	174	19	cases	case	NOUN
admet-36	174	20	where	where	SCONJ
admet-36	174	21	lipophilicity	lipophilicity	NOUN
admet-36	174	22	dominates	dominate	VERB
admet-36	174	23	solubility	solubility	NOUN
admet-36	174	24	limitation	limitation	NOUN
admet-36	174	25	.	.	PUNCT
admet-36	175	1	table	table	NOUN
admet-36	175	2	5	5	NUM
admet-36	175	3	.	.	PUNCT
admet-36	175	4	average	average	ADJ
admet-36	175	5	and	and	CCONJ
admet-36	175	6	median	median	ADJ
admet-36	175	7	values	value	NOUN
admet-36	175	8	of	of	ADP
admet-36	175	9	psa	psa	NOUN
admet-36	175	10	for	for	ADP
admet-36	175	11	compounds	compound	NOUN
admet-36	175	12	classified	classify	VERB
admet-36	175	13	by	by	ADP
admet-36	175	14	type	type	NOUN
admet-36	175	15	of	of	ADP
admet-36	175	16	solubility	solubility	NOUN
admet-36	175	17	limitation	limitation	NOUN
admet-36	175	18	crystal	crystal	NOUN
admet-36	175	19	lattice	lattice	PROPN
admet-36	175	20	limited	limit	VERB
admet-36	175	21	lipophilicity	lipophilicity	NOUN
admet-36	175	22	limited	limit	VERB
admet-36	175	23	average	average	ADJ
admet-36	175	24	psa	psa	NOUN
admet-36	175	25	/	/	SYM
admet-36	175	26	å2	å2	PROPN
admet-36	175	27	82.3	82.3	NUM
admet-36	175	28	71.4	71.4	NUM
admet-36	175	29	median	median	ADJ
admet-36	175	30	psa	psa	NOUN
admet-36	175	31	/	/	SYM
admet-36	175	32	å2	å2	PROPN
admet-36	175	33	83.1	83.1	NUM
admet-36	175	34	69.8	69.8	NUM
admet-36	175	35	admet	admet	PROPN
admet-36	175	36	&	&	CCONJ
admet-36	175	37	dmpk	dmpk	PROPN
admet-36	175	38	2(2	2(2	NUM
admet-36	175	39	)	)	PUNCT
admet-36	175	40	(	(	PUNCT
admet-36	175	41	2014	2014	NUM
admet-36	175	42	)	)	PUNCT
admet-36	175	43	115	115	NUM
admet-36	175	44	-	-	SYM
admet-36	175	45	125	125	NUM
admet-36	175	46	diagnosing	diagnosing	NOUN
admet-36	175	47	solubility	solubility	NOUN
admet-36	175	48	limitations	limitation	NOUN
admet-36	175	49	doi	doi	NOUN
admet-36	175	50	:	:	PUNCT
admet-36	175	51	10.5599	10.5599	NUM
admet-36	175	52	/	/	SYM
admet-36	175	53	admet.2.2.36	admet.2.2.36	NOUN
admet-36	175	54	123	123	NUM
admet-36	175	55	(	(	PUNCT
admet-36	175	56	a	a	NOUN
admet-36	175	57	)	)	PUNCT
admet-36	175	58	(	(	PUNCT
admet-36	175	59	b	b	X
admet-36	175	60	)	)	PUNCT
admet-36	175	61	figure	figure	NOUN
admet-36	175	62	2	2	NUM
admet-36	175	63	.	.	PUNCT
admet-36	176	1	(	(	PUNCT
admet-36	176	2	a	a	DET
admet-36	176	3	)	)	PUNCT
admet-36	176	4	frequency	frequency	NOUN
admet-36	176	5	distribution	distribution	NOUN
admet-36	176	6	of	of	ADP
admet-36	176	7	psa	psa	NOUN
admet-36	176	8	for	for	ADP
admet-36	176	9	compounds	compound	NOUN
admet-36	176	10	being	be	AUX
admet-36	176	11	mainly	mainly	ADV
admet-36	176	12	solubility	solubility	NOUN
admet-36	176	13	limited	limit	VERB
admet-36	176	14	by	by	ADP
admet-36	176	15	crystal	crystal	PROPN
admet-36	176	16	lattice	lattice	PROPN
admet-36	176	17	fores	fores	PROPN
admet-36	176	18	(	(	PUNCT
admet-36	176	19	b	b	NOUN
admet-36	176	20	)	)	PUNCT
admet-36	176	21	frequency	frequency	NOUN
admet-36	176	22	distribution	distribution	NOUN
admet-36	176	23	of	of	ADP
admet-36	176	24	psa	psa	NOUN
admet-36	176	25	for	for	ADP
admet-36	176	26	compounds	compound	NOUN
admet-36	176	27	with	with	ADP
admet-36	176	28	solubility	solubility	NOUN
admet-36	176	29	mainly	mainly	ADV
admet-36	176	30	limited	limit	VERB
admet-36	176	31	by	by	ADP
admet-36	176	32	lipophilicity	lipophilicity	PROPN
admet-36	176	33	.	.	PUNCT
admet-36	177	1	compounds	compound	NOUN
admet-36	177	2	that	that	PRON
admet-36	177	3	have	have	AUX
admet-36	177	4	undergone	undergo	VERB
admet-36	177	5	solubility	solubility	NOUN
admet-36	177	6	diagnosis	diagnosis	NOUN
admet-36	177	7	so	so	ADV
admet-36	177	8	far	far	ADV
admet-36	177	9	represent	represent	VERB
admet-36	177	10	a	a	DET
admet-36	177	11	molecular	molecular	ADJ
admet-36	177	12	weight	weight	NOUN
admet-36	177	13	range	range	NOUN
admet-36	177	14	of	of	ADP
admet-36	177	15	approximately	approximately	ADV
admet-36	177	16	255	255	NUM
admet-36	177	17	to	to	ADP
admet-36	177	18	600	600	NUM
admet-36	177	19	g	g	NOUN
admet-36	177	20	/	/	SYM
admet-36	177	21	mol	mol	NOUN
admet-36	177	22	and	and	CCONJ
admet-36	177	23	calculated	calculate	VERB
admet-36	177	24	log	log	NOUN
admet-36	177	25	p	p	NOUN
admet-36	177	26	values	value	NOUN
admet-36	177	27	in	in	ADP
admet-36	177	28	the	the	DET
admet-36	177	29	range	range	NOUN
admet-36	177	30	of	of	ADP
admet-36	177	31	approximately	approximately	ADV
admet-36	177	32	0.4	0.4	NUM
admet-36	177	33	to	to	PART
admet-36	177	34	7	7	NUM
admet-36	177	35	.	.	PUNCT
admet-36	178	1	although	although	SCONJ
admet-36	178	2	increasing	increase	VERB
admet-36	178	3	molecular	molecular	ADJ
admet-36	178	4	weight	weight	NOUN
admet-36	178	5	leads	lead	VERB
admet-36	178	6	to	to	ADP
admet-36	178	7	increasing	increase	VERB
admet-36	178	8	psa	psa	NOUN
admet-36	178	9	,	,	PUNCT
admet-36	178	10	see	see	VERB
admet-36	178	11	figure	figure	NOUN
admet-36	178	12	3	3	NUM
admet-36	178	13	(	(	PUNCT
admet-36	178	14	a	a	NOUN
admet-36	178	15	)	)	PUNCT
admet-36	178	16	,	,	PUNCT
admet-36	178	17	most	most	ADJ
admet-36	178	18	of	of	ADP
admet-36	178	19	the	the	DET
admet-36	178	20	compounds	compound	NOUN
admet-36	178	21	cluster	cluster	NOUN
admet-36	178	22	between	between	ADP
admet-36	178	23	a	a	DET
admet-36	178	24	psa	psa	NOUN
admet-36	178	25	of	of	ADP
admet-36	178	26	60	60	NUM
admet-36	178	27	å2	å2	NOUN
admet-36	178	28	and	and	CCONJ
admet-36	178	29	120	120	NUM
admet-36	178	30	å2	å2	NOUN
admet-36	178	31	and	and	CCONJ
admet-36	178	32	comprise	comprise	VERB
admet-36	178	33	the	the	DET
admet-36	178	34	full	full	ADJ
admet-36	178	35	range	range	NOUN
admet-36	178	36	of	of	ADP
admet-36	178	37	molecular	molecular	ADJ
admet-36	178	38	weight	weight	NOUN
admet-36	178	39	represented	represent	VERB
admet-36	178	40	in	in	ADP
admet-36	178	41	the	the	DET
admet-36	178	42	dataset	dataset	NOUN
admet-36	178	43	.	.	PUNCT
admet-36	179	1	similarly	similarly	ADV
admet-36	179	2	,	,	PUNCT
admet-36	179	3	compounds	compound	VERB
admet-36	179	4	with	with	ADP
admet-36	179	5	higher	high	ADJ
admet-36	179	6	psa	psa	NOUN
admet-36	179	7	by	by	ADP
admet-36	179	8	trend	trend	NOUN
admet-36	179	9	are	be	AUX
admet-36	179	10	characterized	characterize	VERB
admet-36	179	11	by	by	ADP
admet-36	179	12	a	a	DET
admet-36	179	13	lower	lower	ADV
admet-36	179	14	calculated	calculate	VERB
admet-36	179	15	log	log	NOUN
admet-36	179	16	p	p	NOUN
admet-36	179	17	,	,	PUNCT
admet-36	179	18	see	see	VERB
admet-36	179	19	figure	figure	NOUN
admet-36	179	20	3	3	NUM
admet-36	179	21	(	(	PUNCT
admet-36	179	22	b	b	NOUN
admet-36	179	23	)	)	PUNCT
admet-36	179	24	.	.	PUNCT
admet-36	180	1	however	however	ADV
admet-36	180	2	,	,	PUNCT
admet-36	180	3	there	there	PRON
admet-36	180	4	is	be	VERB
admet-36	180	5	no	no	DET
admet-36	180	6	strong	strong	ADJ
admet-36	180	7	relationship	relationship	NOUN
admet-36	180	8	found	find	VERB
admet-36	180	9	within	within	ADP
admet-36	180	10	the	the	DET
admet-36	180	11	dataset	dataset	NOUN
admet-36	180	12	that	that	PRON
admet-36	180	13	would	would	AUX
admet-36	180	14	allow	allow	VERB
admet-36	180	15	classifying	classify	VERB
admet-36	180	16	the	the	DET
admet-36	180	17	type	type	NOUN
admet-36	180	18	of	of	ADP
admet-36	180	19	solubility	solubility	NOUN
admet-36	180	20	limitation	limitation	NOUN
admet-36	180	21	based	base	VERB
admet-36	180	22	on	on	ADP
admet-36	180	23	molecular	molecular	ADJ
admet-36	180	24	weight	weight	NOUN
admet-36	180	25	only	only	ADV
admet-36	180	26	.	.	PUNCT
admet-36	181	1	however	however	ADV
admet-36	181	2	,	,	PUNCT
admet-36	181	3	based	base	VERB
admet-36	181	4	on	on	ADP
admet-36	181	5	above	above	ADP
admet-36	181	6	mentioned	mention	VERB
admet-36	181	7	findings	finding	NOUN
admet-36	181	8	,	,	PUNCT
admet-36	181	9	it	it	PRON
admet-36	181	10	becomes	become	VERB
admet-36	181	11	evident	evident	ADJ
admet-36	181	12	that	that	SCONJ
admet-36	181	13	the	the	DET
admet-36	181	14	‘	'	PUNCT
admet-36	181	15	general	general	ADJ
admet-36	181	16	solubility	solubility	NOUN
admet-36	181	17	equation	equation	NOUN
admet-36	181	18	’	'	PUNCT
admet-36	181	19	(	(	PUNCT
admet-36	181	20	gse	gse	PROPN
admet-36	181	21	)	)	PUNCT
admet-36	181	22	can	can	AUX
admet-36	181	23	be	be	AUX
admet-36	181	24	successfully	successfully	ADV
admet-36	181	25	refined	refine	VERB
admet-36	181	26	by	by	ADP
admet-36	181	27	including	include	VERB
admet-36	181	28	the	the	DET
admet-36	181	29	psa	psa	NOUN
admet-36	182	1	[	[	X
admet-36	182	2	7	7	NUM
admet-36	182	3	]	]	PUNCT
admet-36	182	4	.	.	PUNCT
admet-36	183	1	(	(	PUNCT
admet-36	183	2	a	a	X
admet-36	183	3	)	)	PUNCT
admet-36	183	4	(	(	PUNCT
admet-36	183	5	b	b	X
admet-36	183	6	)	)	PUNCT
admet-36	183	7	figure	figure	NOUN
admet-36	183	8	3	3	NUM
admet-36	183	9	.	.	PUNCT
admet-36	184	1	(	(	PUNCT
admet-36	184	2	a	a	X
admet-36	184	3	)	)	PUNCT
admet-36	184	4	molecular	molecular	ADJ
admet-36	184	5	weight	weight	NOUN
admet-36	184	6	as	as	ADP
admet-36	184	7	a	a	DET
admet-36	184	8	function	function	NOUN
admet-36	184	9	of	of	ADP
admet-36	184	10	psa	psa	NOUN
admet-36	184	11	for	for	ADP
admet-36	184	12	the	the	DET
admet-36	184	13	solubility	solubility	NOUN
admet-36	184	14	diagnosis	diagnosis	NOUN
admet-36	184	15	dataset	dataset	VERB
admet-36	184	16	.	.	PUNCT
admet-36	185	1	(	(	PUNCT
admet-36	185	2	b	b	X
admet-36	185	3	)	)	PUNCT
admet-36	185	4	calculated	calculate	VERB
admet-36	185	5	logp	logp	NOUN
admet-36	185	6	as	as	ADP
admet-36	185	7	a	a	DET
admet-36	185	8	function	function	NOUN
admet-36	185	9	of	of	ADP
admet-36	185	10	psa	psa	NOUN
admet-36	185	11	for	for	ADP
admet-36	185	12	the	the	DET
admet-36	185	13	solubility	solubility	NOUN
admet-36	185	14	diagnosis	diagnosis	NOUN
admet-36	185	15	dataset	dataset	VERB
admet-36	185	16	conclusions	conclusion	NOUN
admet-36	185	17	solubility	solubility	NOUN
admet-36	185	18	diagnosis	diagnosis	NOUN
admet-36	185	19	has	have	AUX
admet-36	185	20	proven	prove	VERB
admet-36	185	21	to	to	PART
admet-36	185	22	be	be	AUX
admet-36	185	23	a	a	DET
admet-36	185	24	very	very	ADV
admet-36	185	25	useful	useful	ADJ
admet-36	185	26	tool	tool	NOUN
admet-36	185	27	for	for	ADP
admet-36	185	28	understanding	understand	VERB
admet-36	185	29	the	the	DET
admet-36	185	30	solubility	solubility	NOUN
admet-36	185	31	limiting	limit	VERB
admet-36	185	32	factors	factor	NOUN
admet-36	185	33	of	of	ADP
admet-36	185	34	drug	drug	NOUN
admet-36	185	35	-	-	PUNCT
admet-36	185	36	like	like	ADJ
admet-36	185	37	molecules	molecule	NOUN
admet-36	185	38	.	.	PUNCT
admet-36	186	1	by	by	ADP
admet-36	186	2	comparing	compare	VERB
admet-36	186	3	contributions	contribution	NOUN
admet-36	186	4	from	from	ADP
admet-36	186	5	lipophilicity	lipophilicity	NOUN
admet-36	186	6	,	,	PUNCT
admet-36	186	7	crystal	crystal	NOUN
admet-36	186	8	lattice	lattice	PROPN
admet-36	186	9	energy	energy	NOUN
admet-36	186	10	and	and	CCONJ
admet-36	186	11	ionization	ionization	NOUN
admet-36	186	12	,	,	PUNCT
admet-36	186	13	the	the	DET
admet-36	186	14	dominant	dominant	ADJ
admet-36	186	15	factors	factor	NOUN
admet-36	186	16	that	that	PRON
admet-36	186	17	limit	limit	VERB
admet-36	186	18	solubility	solubility	NOUN
admet-36	186	19	are	be	AUX
admet-36	186	20	identified	identify	VERB
admet-36	186	21	.	.	PUNCT
admet-36	187	1	however	however	ADV
admet-36	187	2	,	,	PUNCT
admet-36	187	3	the	the	DET
admet-36	187	4	solid	solid	ADJ
admet-36	187	5	state	state	NOUN
admet-36	187	6	of	of	ADP
admet-36	187	7	a	a	DET
admet-36	187	8	compound	compound	NOUN
admet-36	187	9	is	be	AUX
admet-36	187	10	typically	typically	ADV
admet-36	187	11	not	not	PART
admet-36	187	12	berghausen	berghausen	VERB
admet-36	187	13	and	and	CCONJ
admet-36	187	14	faller	faller	NOUN
admet-36	187	15	admet	admet	PROPN
admet-36	187	16	&	&	CCONJ
admet-36	187	17	dmpk	dmpk	PROPN
admet-36	187	18	2(2	2(2	NUM
admet-36	187	19	)	)	PUNCT
admet-36	187	20	(	(	PUNCT
admet-36	187	21	2014	2014	NUM
admet-36	187	22	)	)	PUNCT
admet-36	187	23	115	115	NUM
admet-36	187	24	-	-	SYM
admet-36	187	25	125	125	NUM
admet-36	187	26	124	124	NUM
admet-36	187	27	well	well	ADV
admet-36	187	28	understood	understand	VERB
admet-36	187	29	during	during	ADP
admet-36	187	30	lead	lead	ADJ
admet-36	187	31	optimization	optimization	NOUN
admet-36	187	32	efforts	effort	NOUN
admet-36	187	33	.	.	PUNCT
admet-36	188	1	thus	thus	ADV
admet-36	188	2	,	,	PUNCT
admet-36	188	3	changes	change	NOUN
admet-36	188	4	of	of	ADP
admet-36	188	5	solid	solid	ADJ
admet-36	188	6	state	state	NOUN
admet-36	188	7	can	can	AUX
admet-36	188	8	significantly	significantly	ADV
admet-36	188	9	impact	impact	VERB
admet-36	188	10	the	the	DET
admet-36	188	11	conclusions	conclusion	NOUN
admet-36	188	12	drawn	draw	VERB
admet-36	188	13	on	on	ADP
admet-36	188	14	its	its	PRON
admet-36	188	15	contribution	contribution	NOUN
admet-36	188	16	to	to	ADP
admet-36	188	17	solubility	solubility	NOUN
admet-36	188	18	limitation	limitation	NOUN
admet-36	188	19	.	.	PUNCT
admet-36	189	1	in	in	ADP
admet-36	189	2	this	this	DET
admet-36	189	3	work	work	NOUN
admet-36	189	4	,	,	PUNCT
admet-36	189	5	solubility	solubility	NOUN
admet-36	189	6	limitations	limitation	NOUN
admet-36	189	7	of	of	ADP
admet-36	189	8	hydrated	hydrated	ADJ
admet-36	189	9	forms	form	NOUN
admet-36	189	10	of	of	ADP
admet-36	189	11	drug	drug	NOUN
admet-36	189	12	-	-	PUNCT
admet-36	189	13	like	like	ADJ
admet-36	189	14	compounds	compound	NOUN
admet-36	189	15	were	be	AUX
admet-36	189	16	investigated	investigate	VERB
admet-36	189	17	.	.	PUNCT
admet-36	190	1	it	it	PRON
admet-36	190	2	is	be	AUX
admet-36	190	3	concluded	conclude	VERB
admet-36	190	4	that	that	SCONJ
admet-36	190	5	the	the	DET
admet-36	190	6	contribution	contribution	NOUN
admet-36	190	7	of	of	ADP
admet-36	190	8	hydrates	hydrate	NOUN
admet-36	190	9	to	to	ADP
admet-36	190	10	solubility	solubility	NOUN
admet-36	190	11	limitation	limitation	NOUN
admet-36	190	12	might	might	AUX
admet-36	190	13	be	be	AUX
admet-36	190	14	underestimated	underestimate	VERB
admet-36	190	15	and	and	CCONJ
admet-36	190	16	that	that	SCONJ
admet-36	190	17	hydrates	hydrate	NOUN
admet-36	190	18	and	and	CCONJ
admet-36	190	19	solvates	solvate	NOUN
admet-36	190	20	are	be	AUX
admet-36	190	21	special	special	ADJ
admet-36	190	22	cases	case	NOUN
admet-36	190	23	that	that	PRON
admet-36	190	24	are	be	AUX
admet-36	190	25	not	not	PART
admet-36	190	26	necessarily	necessarily	ADV
admet-36	190	27	sufficiently	sufficiently	ADV
admet-36	190	28	characterized	characterize	VERB
admet-36	190	29	during	during	ADP
admet-36	190	30	solubility	solubility	NOUN
admet-36	190	31	diagnosis	diagnosis	NOUN
admet-36	190	32	.	.	PUNCT
admet-36	191	1	this	this	PRON
admet-36	191	2	is	be	AUX
admet-36	191	3	due	due	ADJ
admet-36	191	4	to	to	ADP
admet-36	191	5	the	the	DET
admet-36	191	6	fact	fact	NOUN
admet-36	191	7	,	,	PUNCT
admet-36	191	8	that	that	SCONJ
admet-36	191	9	the	the	DET
admet-36	191	10	melting	melting	NOUN
admet-36	191	11	temperature	temperature	NOUN
admet-36	191	12	is	be	AUX
admet-36	191	13	used	use	VERB
admet-36	191	14	as	as	ADP
admet-36	191	15	a	a	DET
admet-36	191	16	surrogate	surrogate	NOUN
admet-36	191	17	for	for	ADP
admet-36	191	18	crystal	crystal	PROPN
admet-36	191	19	lattice	lattice	PROPN
admet-36	191	20	energy	energy	NOUN
admet-36	191	21	.	.	PUNCT
admet-36	192	1	since	since	SCONJ
admet-36	192	2	hydrates	hydrate	NOUN
admet-36	192	3	may	may	AUX
admet-36	192	4	either	either	CCONJ
admet-36	192	5	decompose	decompose	VERB
admet-36	192	6	during	during	ADP
admet-36	192	7	dsc	dsc	NOUN
admet-36	192	8	measurements	measurement	NOUN
admet-36	192	9	or	or	CCONJ
admet-36	192	10	may	may	AUX
admet-36	192	11	transform	transform	VERB
admet-36	192	12	into	into	ADP
admet-36	192	13	anhydrates	anhydrate	NOUN
admet-36	192	14	during	during	ADP
admet-36	192	15	heating	heating	NOUN
admet-36	192	16	,	,	PUNCT
admet-36	192	17	melting	melt	VERB
admet-36	192	18	temperature	temperature	NOUN
admet-36	192	19	no	no	ADV
admet-36	192	20	longer	long	ADV
admet-36	192	21	allows	allow	VERB
admet-36	192	22	conclusions	conclusion	NOUN
admet-36	192	23	on	on	ADP
admet-36	192	24	solid	solid	ADJ
admet-36	192	25	state	state	NOUN
admet-36	192	26	contributions	contribution	NOUN
admet-36	192	27	.	.	PUNCT
admet-36	193	1	the	the	DET
admet-36	193	2	tendency	tendency	NOUN
admet-36	193	3	of	of	ADP
admet-36	193	4	a	a	DET
admet-36	193	5	compound	compound	NOUN
admet-36	193	6	to	to	PART
admet-36	193	7	exist	exist	VERB
admet-36	193	8	in	in	ADP
admet-36	193	9	hydrated	hydrated	ADJ
admet-36	193	10	,	,	PUNCT
admet-36	193	11	or	or	CCONJ
admet-36	193	12	more	more	ADV
admet-36	193	13	generally	generally	ADV
admet-36	193	14	solvated	solvate	VERB
admet-36	193	15	,	,	PUNCT
admet-36	193	16	forms	form	NOUN
admet-36	193	17	might	might	AUX
admet-36	193	18	help	help	VERB
admet-36	193	19	to	to	PART
admet-36	193	20	understand	understand	VERB
admet-36	193	21	the	the	DET
admet-36	193	22	combination	combination	NOUN
admet-36	193	23	of	of	ADP
admet-36	193	24	a	a	DET
admet-36	193	25	strong	strong	ADJ
admet-36	193	26	solubility	solubility	NOUN
admet-36	193	27	limitation	limitation	NOUN
admet-36	193	28	beyond	beyond	ADP
admet-36	193	29	lipophilicity	lipophilicity	NOUN
admet-36	193	30	,	,	PUNCT
admet-36	193	31	i.e.	i.e.	X
admet-36	193	32	a	a	DET
admet-36	193	33	high	high	ADJ
admet-36	193	34	sl	sl	ADJ
admet-36	193	35	value	value	NOUN
admet-36	193	36	,	,	PUNCT
admet-36	193	37	and	and	CCONJ
admet-36	193	38	a	a	DET
admet-36	193	39	rather	rather	ADV
admet-36	193	40	low	low	ADJ
admet-36	193	41	melting	melting	NOUN
admet-36	193	42	temperature	temperature	NOUN
admet-36	193	43	.	.	PUNCT
admet-36	194	1	therefore	therefore	ADV
admet-36	194	2	,	,	PUNCT
admet-36	194	3	the	the	DET
admet-36	194	4	polar	polar	ADJ
admet-36	194	5	surface	surface	NOUN
admet-36	194	6	area	area	NOUN
admet-36	194	7	(	(	PUNCT
admet-36	194	8	psa	psa	NOUN
admet-36	194	9	)	)	PUNCT
admet-36	194	10	was	be	AUX
admet-36	194	11	introduced	introduce	VERB
admet-36	194	12	as	as	ADP
admet-36	194	13	additional	additional	ADJ
admet-36	194	14	parameter	parameter	NOUN
admet-36	194	15	to	to	PART
admet-36	194	16	deal	deal	VERB
admet-36	194	17	with	with	ADP
admet-36	194	18	the	the	DET
admet-36	194	19	possibility	possibility	NOUN
admet-36	194	20	of	of	ADP
admet-36	194	21	hydrate	hydrate	ADJ
admet-36	194	22	formation	formation	NOUN
admet-36	194	23	.	.	PUNCT
admet-36	195	1	beyond	beyond	ADP
admet-36	195	2	that	that	PRON
admet-36	195	3	,	,	PUNCT
admet-36	195	4	analysis	analysis	NOUN
admet-36	195	5	of	of	ADP
admet-36	195	6	the	the	DET
admet-36	195	7	dataset	dataset	NOUN
admet-36	195	8	comprising	comprising	NOUN
admet-36	195	9	about	about	ADV
admet-36	195	10	200	200	NUM
admet-36	195	11	proprietary	proprietary	ADJ
admet-36	195	12	compounds	compound	NOUN
admet-36	195	13	that	that	PRON
admet-36	195	14	were	be	AUX
admet-36	195	15	run	run	VERB
admet-36	195	16	through	through	ADP
admet-36	195	17	the	the	DET
admet-36	195	18	solubility	solubility	NOUN
admet-36	195	19	diagnosis	diagnosis	NOUN
admet-36	195	20	revealed	reveal	VERB
admet-36	195	21	that	that	SCONJ
admet-36	195	22	the	the	DET
admet-36	195	23	polar	polar	ADJ
admet-36	195	24	surface	surface	NOUN
admet-36	195	25	area	area	NOUN
admet-36	195	26	is	be	AUX
admet-36	195	27	not	not	PART
admet-36	195	28	only	only	ADV
admet-36	195	29	a	a	DET
admet-36	195	30	valuable	valuable	ADJ
admet-36	195	31	descriptor	descriptor	NOUN
admet-36	195	32	to	to	PART
admet-36	195	33	estimate	estimate	VERB
admet-36	195	34	the	the	DET
admet-36	195	35	possibility	possibility	NOUN
admet-36	195	36	of	of	ADP
admet-36	195	37	hydrate	hydrate	ADJ
admet-36	195	38	formation	formation	NOUN
admet-36	195	39	,	,	PUNCT
admet-36	195	40	but	but	CCONJ
admet-36	195	41	can	can	AUX
admet-36	195	42	also	also	ADV
admet-36	195	43	provide	provide	VERB
admet-36	195	44	guidance	guidance	NOUN
admet-36	195	45	to	to	PART
admet-36	195	46	distinguish	distinguish	VERB
admet-36	195	47	the	the	DET
admet-36	195	48	type	type	NOUN
admet-36	195	49	of	of	ADP
admet-36	195	50	solubility	solubility	NOUN
admet-36	195	51	limitation	limitation	NOUN
admet-36	195	52	.	.	PUNCT
admet-36	196	1	a	a	DET
admet-36	196	2	cutoff	cutoff	NOUN
admet-36	196	3	value	value	NOUN
admet-36	196	4	for	for	ADP
admet-36	196	5	psa	psa	NOUN
admet-36	196	6	around	around	ADP
admet-36	196	7	100å2	100å2	NUM
admet-36	196	8	may	may	AUX
admet-36	196	9	be	be	AUX
admet-36	196	10	used	use	VERB
admet-36	196	11	to	to	PART
admet-36	196	12	classify	classify	VERB
admet-36	196	13	compounds	compound	NOUN
admet-36	196	14	with	with	ADP
admet-36	196	15	respect	respect	NOUN
admet-36	196	16	to	to	ADP
admet-36	196	17	their	their	PRON
admet-36	196	18	type	type	NOUN
admet-36	196	19	of	of	ADP
admet-36	196	20	solubility	solubility	NOUN
admet-36	196	21	limitation	limitation	NOUN
admet-36	196	22	.	.	PUNCT
admet-36	197	1	data	datum	NOUN
admet-36	197	2	analysis	analysis	NOUN
admet-36	197	3	has	have	AUX
admet-36	197	4	shown	show	VERB
admet-36	197	5	that	that	SCONJ
admet-36	197	6	for	for	ADP
admet-36	197	7	compounds	compound	NOUN
admet-36	197	8	with	with	ADP
admet-36	197	9	a	a	DET
admet-36	197	10	psa	psa	NOUN
admet-36	197	11	above	above	ADP
admet-36	197	12	this	this	DET
admet-36	197	13	value	value	NOUN
admet-36	197	14	,	,	PUNCT
admet-36	197	15	cases	case	NOUN
admet-36	197	16	of	of	ADP
admet-36	197	17	lipophilicity	lipophilicity	NOUN
admet-36	197	18	dominated	dominate	VERB
admet-36	197	19	solubility	solubility	NOUN
admet-36	197	20	limitation	limitation	NOUN
admet-36	197	21	are	be	AUX
admet-36	197	22	rather	rather	ADV
admet-36	197	23	rare	rare	ADJ
admet-36	197	24	.	.	PUNCT
admet-36	198	1	instead	instead	ADV
admet-36	198	2	,	,	PUNCT
admet-36	198	3	solubility	solubility	NOUN
admet-36	198	4	limitation	limitation	NOUN
admet-36	198	5	by	by	ADP
admet-36	198	6	crystal	crystal	NOUN
admet-36	198	7	lattice	lattice	PROPN
admet-36	198	8	forces	force	NOUN
admet-36	198	9	is	be	AUX
admet-36	198	10	dominant	dominant	ADJ
admet-36	198	11	for	for	ADP
admet-36	198	12	such	such	ADJ
admet-36	198	13	compounds	compound	NOUN
admet-36	198	14	,	,	PUNCT
admet-36	198	15	at	at	ADP
admet-36	198	16	least	least	ADJ
admet-36	198	17	in	in	ADP
admet-36	198	18	the	the	DET
admet-36	198	19	chemical	chemical	NOUN
admet-36	198	20	space	space	NOUN
admet-36	198	21	represented	represent	VERB
admet-36	198	22	by	by	ADP
admet-36	198	23	the	the	DET
admet-36	198	24	investigated	investigate	VERB
admet-36	198	25	dataset	dataset	NOUN
admet-36	198	26	.	.	PUNCT
admet-36	199	1	acknowledgements	acknowledgement	NOUN
admet-36	199	2	:	:	PUNCT
admet-36	199	3	data	datum	NOUN
admet-36	199	4	generation	generation	NOUN
admet-36	199	5	and	and	CCONJ
admet-36	199	6	solid	solid	ADJ
admet-36	199	7	state	state	NOUN
admet-36	199	8	characterization	characterization	NOUN
admet-36	199	9	was	be	AUX
admet-36	199	10	greatly	greatly	ADV
admet-36	199	11	supported	support	VERB
admet-36	199	12	by	by	ADP
admet-36	199	13	stephane	stephane	PROPN
admet-36	199	14	rodde	rodde	PROPN
admet-36	199	15	and	and	CCONJ
admet-36	199	16	daniel	daniel	PROPN
admet-36	199	17	gosling	gosling	PROPN
admet-36	199	18	,	,	PUNCT
admet-36	199	19	and	and	CCONJ
admet-36	199	20	the	the	DET
admet-36	199	21	authors	author	NOUN
admet-36	199	22	would	would	AUX
admet-36	199	23	like	like	VERB
admet-36	199	24	to	to	PART
admet-36	199	25	acknowledge	acknowledge	VERB
admet-36	199	26	their	their	PRON
admet-36	199	27	contribution	contribution	NOUN
admet-36	199	28	to	to	ADP
admet-36	199	29	this	this	DET
admet-36	199	30	publication	publication	NOUN
admet-36	199	31	.	.	PUNCT
admet-36	200	1	references	reference	NOUN
admet-36	200	2	[	[	X
admet-36	200	3	1	1	NUM
admet-36	200	4	]	]	X
admet-36	200	5	c.a	c.a	PROPN
admet-36	200	6	.	.	PROPN
admet-36	200	7	lipinski	lipinski	PROPN
admet-36	200	8	,	,	PUNCT
admet-36	200	9	journal	journal	NOUN
admet-36	200	10	of	of	ADP
admet-36	200	11	pharmacological	pharmacological	ADJ
admet-36	200	12	and	and	CCONJ
admet-36	200	13	toxicological	toxicological	ADJ
admet-36	200	14	methods	method	NOUN
admet-36	200	15	44	44	NUM
admet-36	200	16	(	(	PUNCT
admet-36	200	17	2000	2000	NUM
admet-36	200	18	)	)	PUNCT
admet-36	200	19	235	235	NUM
admet-36	200	20	-	-	SYM
admet-36	200	21	249	249	NUM
admet-36	200	22	[	[	X
admet-36	200	23	2	2	NUM
admet-36	200	24	]	]	X
admet-36	200	25	m.j	m.j	PROPN
admet-36	200	26	.	.	PROPN
admet-36	200	27	waring	waring	NOUN
admet-36	200	28	,	,	PUNCT
admet-36	200	29	expert	expert	ADJ
admet-36	200	30	opinion	opinion	NOUN
admet-36	200	31	on	on	ADP
admet-36	200	32	drug	drug	NOUN
admet-36	200	33	discovery	discovery	NOUN
admet-36	200	34	5	5	NUM
admet-36	200	35	(	(	PUNCT
admet-36	200	36	2010	2010	NUM
admet-36	200	37	)	)	PUNCT
admet-36	200	38	235	235	NUM
admet-36	200	39	-	-	SYM
admet-36	200	40	248	248	NUM
admet-36	201	1	[	[	X
admet-36	201	2	3	3	NUM
admet-36	201	3	]	]	X
admet-36	201	4	c.	c.	PROPN
admet-36	201	5	saal	saal	PROPN
admet-36	201	6	,	,	PUNCT
admet-36	201	7	a.c	a.c	PROPN
admet-36	201	8	.	.	PROPN
admet-36	201	9	petereit	petereit	PROPN
admet-36	201	10	,	,	PUNCT
admet-36	201	11	european	european	ADJ
admet-36	201	12	journal	journal	PROPN
admet-36	201	13	of	of	ADP
admet-36	201	14	pharmaceutical	pharmaceutical	PROPN
admet-36	201	15	sciences	science	NOUN
admet-36	201	16	47	47	NUM
admet-36	201	17	(	(	PUNCT
admet-36	201	18	2012	2012	NUM
admet-36	201	19	)	)	PUNCT
admet-36	201	20	589	589	NUM
admet-36	201	21	-	-	SYM
admet-36	201	22	595	595	NUM
admet-36	202	1	[	[	X
admet-36	202	2	4	4	NUM
admet-36	202	3	]	]	X
admet-36	202	4	j.g	j.g	PROPN
admet-36	202	5	.	.	PROPN
admet-36	202	6	cumming	cumming	PROPN
admet-36	202	7	,	,	PUNCT
admet-36	202	8	a.m.	a.m.	PROPN
admet-36	202	9	davis	davis	PROPN
admet-36	202	10	,	,	PUNCT
admet-36	202	11	s.	s.	PROPN
admet-36	202	12	muresan	muresan	PROPN
admet-36	202	13	,	,	PUNCT
admet-36	202	14	m.	m.	NOUN
admet-36	202	15	haeberlein	haeberlein	PROPN
admet-36	202	16	,	,	PUNCT
admet-36	202	17	h.	h.	PROPN
admet-36	202	18	chen	chen	PROPN
admet-36	202	19	,	,	PUNCT
admet-36	202	20	nature	nature	NOUN
admet-36	202	21	reviews	review	VERB
admet-36	202	22	drug	drug	NOUN
admet-36	202	23	discovery	discovery	NOUN
admet-36	202	24	12	12	NUM
admet-36	202	25	(	(	PUNCT
admet-36	202	26	2013	2013	NUM
admet-36	202	27	)	)	PUNCT
admet-36	202	28	948	948	NUM
admet-36	202	29	-	-	SYM
admet-36	202	30	962	962	NUM
admet-36	203	1	[	[	X
admet-36	203	2	5	5	NUM
admet-36	203	3	]	]	PUNCT
admet-36	203	4	c.a.s	c.a.s	PROPN
admet-36	203	5	.	.	PUNCT
admet-36	203	6	bergström	bergström	PROPN
admet-36	203	7	,	,	PUNCT
admet-36	203	8	c.m	c.m	PROPN
admet-36	203	9	.	.	PROPN
admet-36	203	10	wassvik	wassvik	PROPN
admet-36	203	11	,	,	PUNCT
admet-36	203	12	u.	u.	PROPN
admet-36	203	13	norinder	norinder	PROPN
admet-36	203	14	,	,	PUNCT
admet-36	203	15	k.	k.	PROPN
admet-36	203	16	luthman	luthman	PROPN
admet-36	203	17	,	,	PUNCT
admet-36	203	18	p.	p.	PROPN
admet-36	203	19	artursson	artursson	PROPN
admet-36	203	20	,	,	PUNCT
admet-36	203	21	journal	journal	NOUN
admet-36	203	22	of	of	ADP
admet-36	203	23	chemical	chemical	ADJ
admet-36	203	24	information	information	NOUN
admet-36	203	25	and	and	CCONJ
admet-36	203	26	computer	computer	NOUN
admet-36	203	27	sciences	science	NOUN
admet-36	203	28	44	44	NUM
admet-36	203	29	(	(	PUNCT
admet-36	203	30	2004	2004	NUM
admet-36	203	31	)	)	PUNCT
admet-36	203	32	,	,	PUNCT
admet-36	203	33	1477	1477	NUM
admet-36	203	34	-	-	SYM
admet-36	203	35	1488	1488	NUM
admet-36	203	36	[	[	X
admet-36	203	37	6	6	NUM
admet-36	203	38	]	]	SYM
admet-36	203	39	c.m	c.m	PROPN
admet-36	203	40	.	.	PROPN
admet-36	203	41	wassvik	wassvik	PROPN
admet-36	203	42	,	,	PUNCT
admet-36	203	43	a.g	a.g	PROPN
admet-36	203	44	.	.	PROPN
admet-36	203	45	holmén	holmén	PROPN
admet-36	203	46	,	,	PUNCT
admet-36	203	47	r.	r.	PROPN
admet-36	203	48	draheim	draheim	PROPN
admet-36	203	49	,	,	PUNCT
admet-36	203	50	p.	p.	PROPN
admet-36	203	51	artursson	artursson	PROPN
admet-36	203	52	,	,	PUNCT
admet-36	203	53	c.a.s	c.a.s	PROPN
admet-36	204	1	.	.	PROPN
admet-36	204	2	bergström	bergström	PROPN
admet-36	204	3	,	,	PUNCT
admet-36	204	4	journal	journal	NOUN
admet-36	204	5	of	of	ADP
admet-36	204	6	medicinal	medicinal	ADJ
admet-36	204	7	chemistry	chemistry	NOUN
admet-36	204	8	51	51	NUM
admet-36	204	9	(	(	PUNCT
admet-36	204	10	2008	2008	NUM
admet-36	204	11	)	)	PUNCT
admet-36	204	12	3035	3035	NUM
admet-36	204	13	-	-	SYM
admet-36	204	14	3039	3039	NUM
admet-36	205	1	[	[	X
admet-36	205	2	7	7	NUM
admet-36	205	3	]	]	X
admet-36	205	4	j.	j.	PROPN
admet-36	205	5	ali	ali	PROPN
admet-36	205	6	,	,	PUNCT
admet-36	205	7	p.camilleri	p.camilleri	PROPN
admet-36	205	8	,	,	PUNCT
admet-36	205	9	m.b	m.b	PROPN
admet-36	205	10	.	.	PROPN
admet-36	205	11	brown	brown	PROPN
admet-36	205	12	,	,	PUNCT
admet-36	205	13	a.j	a.j	PROPN
admet-36	205	14	.	.	PROPN
admet-36	205	15	hutt	hutt	PROPN
admet-36	205	16	,	,	PUNCT
admet-36	205	17	s.b	s.b	PROPN
admet-36	205	18	.	.	PROPN
admet-36	205	19	kirton	kirton	PROPN
admet-36	205	20	,	,	PUNCT
admet-36	205	21	journal	journal	NOUN
admet-36	205	22	of	of	ADP
admet-36	205	23	chemical	chemical	ADJ
admet-36	205	24	information	information	NOUN
admet-36	205	25	and	and	CCONJ
admet-36	205	26	modeling	modeling	NOUN
admet-36	205	27	52(2	52(2	NUM
admet-36	205	28	)	)	PUNCT
admet-36	205	29	(	(	PUNCT
admet-36	205	30	2012	2012	NUM
admet-36	205	31	)	)	PUNCT
admet-36	205	32	420	420	NUM
admet-36	205	33	-	-	SYM
admet-36	205	34	428	428	NUM
admet-36	206	1	[	[	SYM
admet-36	206	2	8	8	NUM
admet-36	206	3	]	]	X
admet-36	206	4	f.	f.	PROPN
admet-36	206	5	lombardo	lombardo	PROPN
admet-36	206	6	,	,	PUNCT
admet-36	206	7	m.	m.	NOUN
admet-36	206	8	shalaeva	shalaeva	PROPN
admet-36	206	9	,	,	PUNCT
admet-36	206	10	k.	k.	PROPN
admet-36	206	11	tupper	tupper	PROPN
admet-36	206	12	,	,	PUNCT
admet-36	206	13	f.	f.	PROPN
admet-36	206	14	gao	gao	PROPN
admet-36	206	15	,	,	PUNCT
admet-36	206	16	m.	m.	PROPN
admet-36	206	17	abraham	abraham	PROPN
admet-36	206	18	,	,	PUNCT
admet-36	206	19	journal	journal	NOUN
admet-36	206	20	of	of	ADP
admet-36	206	21	medicinal	medicinal	ADJ
admet-36	206	22	chemistry	chemistry	NOUN
admet-36	206	23	43	43	NUM
admet-36	206	24	(	(	PUNCT
admet-36	206	25	2000	2000	NUM
admet-36	206	26	)	)	PUNCT
admet-36	206	27	,	,	PUNCT
admet-36	206	28	2922	2922	NUM
admet-36	206	29	-	-	SYM
admet-36	206	30	2928	2928	NUM
admet-36	206	31	[	[	X
admet-36	206	32	9	9	NUM
admet-36	206	33	]	]	PUNCT
admet-36	206	34	a.	a.	NOUN
admet-36	206	35	avdeef	avdeef	PROPN
admet-36	206	36	,	,	PUNCT
admet-36	206	37	k.j	k.j	PROPN
admet-36	206	38	.	.	PROPN
admet-36	206	39	box	box	PROPN
admet-36	206	40	,	,	PUNCT
admet-36	206	41	j.e.a	j.e.a	PROPN
admet-36	206	42	.	.	PUNCT
admet-36	206	43	comer	comer	PROPN
admet-36	206	44	,	,	PUNCT
admet-36	206	45	m.	m.	NOUN
admet-36	206	46	gilges	gilge	NOUN
admet-36	206	47	,	,	PUNCT
admet-36	206	48	m.	m.	NOUN
admet-36	206	49	hadley	hadley	PROPN
admet-36	206	50	,	,	PUNCT
admet-36	206	51	c.	c.	PROPN
admet-36	206	52	hibbert	hibbert	PROPN
admet-36	206	53	,	,	PUNCT
admet-36	206	54	w.	w.	PROPN
admet-36	206	55	patterson	patterson	PROPN
admet-36	206	56	and	and	CCONJ
admet-36	206	57	k.y	k.y	PROPN
admet-36	206	58	.	.	PROPN
admet-36	206	59	tam	tam	PROPN
admet-36	206	60	,	,	PUNCT
admet-36	206	61	journal	journal	NOUN
admet-36	206	62	of	of	ADP
admet-36	206	63	pharmaceutical	pharmaceutical	NOUN
admet-36	206	64	and	and	CCONJ
admet-36	206	65	biomedical	biomedical	ADJ
admet-36	206	66	analysis	analysis	NOUN
admet-36	206	67	,	,	PUNCT
admet-36	206	68	20	20	NUM
admet-36	206	69	(	(	PUNCT
admet-36	206	70	1999	1999	NUM
admet-36	206	71	)	)	PUNCT
admet-36	206	72	,	,	PUNCT
admet-36	206	73	631	631	NUM
admet-36	206	74	-	-	SYM
admet-36	206	75	641	641	NUM
admet-36	206	76	[	[	SYM
admet-36	206	77	10	10	NUM
admet-36	206	78	]	]	PUNCT
admet-36	206	79	a.	a.	NOUN
admet-36	206	80	avdeef	avdeef	PROPN
admet-36	206	81	,	,	PUNCT
admet-36	206	82	v.m	v.m	PROPN
admet-36	206	83	.	.	PROPN
admet-36	206	84	berger	berger	PROPN
admet-36	206	85	,	,	PUNCT
admet-36	206	86	c.	c.	PROPN
admet-36	206	87	brownell	brownell	PROPN
admet-36	206	88	,	,	PUNCT
admet-36	206	89	pharmaceutical	pharmaceutical	ADJ
admet-36	206	90	research	research	NOUN
admet-36	206	91	7	7	NUM
admet-36	206	92	(	(	PUNCT
admet-36	206	93	2000	2000	NUM
admet-36	206	94	)	)	PUNCT
admet-36	206	95	85	85	NUM
admet-36	206	96	-	-	SYM
admet-36	206	97	89	89	NUM
admet-36	206	98	[	[	X
admet-36	206	99	11	11	NUM
admet-36	206	100	]	]	X
admet-36	206	101	p.	p.	NOUN
admet-36	206	102	ertl	ertl	PROPN
admet-36	206	103	,	,	PUNCT
admet-36	206	104	b.	b.	PROPN
admet-36	206	105	rohde	rohde	PROPN
admet-36	206	106	,	,	PUNCT
admet-36	206	107	p.	p.	NOUN
admet-36	206	108	selzer	selzer	PROPN
admet-36	206	109	,	,	PUNCT
admet-36	206	110	journal	journal	NOUN
admet-36	206	111	of	of	ADP
admet-36	206	112	medicinal	medicinal	ADJ
admet-36	206	113	chemistry	chemistry	NOUN
admet-36	206	114	43	43	NUM
admet-36	206	115	(	(	PUNCT
admet-36	206	116	2000	2000	NUM
admet-36	206	117	)	)	PUNCT
admet-36	206	118	3714	3714	NUM
admet-36	206	119	-	-	SYM
admet-36	206	120	3717	3717	NUM
admet-36	206	121	[	[	X
admet-36	206	122	12	12	NUM
admet-36	206	123	]	]	X
admet-36	206	124	b.	b.	PROPN
admet-36	206	125	faller	faller	PROPN
admet-36	206	126	,	,	PUNCT
admet-36	206	127	p.	p.	PROPN
admet-36	206	128	ertl	ertl	PROPN
admet-36	206	129	,	,	PUNCT
admet-36	206	130	advanced	advanced	ADJ
admet-36	206	131	drug	drug	NOUN
admet-36	206	132	delivery	delivery	NOUN
admet-36	206	133	reviews	review	VERB
admet-36	206	134	59	59	NUM
admet-36	206	135	(	(	PUNCT
admet-36	206	136	2007	2007	NUM
admet-36	206	137	)	)	PUNCT
admet-36	206	138	533	533	NUM
admet-36	206	139	-	-	SYM
admet-36	206	140	545	545	NUM
admet-36	206	141	admet	admet	NOUN
admet-36	206	142	&	&	CCONJ
admet-36	206	143	dmpk	dmpk	PROPN
admet-36	206	144	2(2	2(2	NUM
admet-36	206	145	)	)	PUNCT
admet-36	206	146	(	(	PUNCT
admet-36	206	147	2014	2014	NUM
admet-36	206	148	)	)	PUNCT
admet-36	206	149	115	115	NUM
admet-36	206	150	-	-	SYM
admet-36	206	151	125	125	NUM
admet-36	206	152	diagnosing	diagnosing	NOUN
admet-36	206	153	solubility	solubility	NOUN
admet-36	206	154	limitations	limitation	NOUN
admet-36	206	155	doi	doi	NOUN
admet-36	206	156	:	:	PUNCT
admet-36	206	157	10.5599	10.5599	NUM
admet-36	206	158	/	/	SYM
admet-36	206	159	admet.2.2.36	admet.2.2.36	NOUN
admet-36	206	160	125	125	NUM
admet-36	207	1	[	[	SYM
admet-36	207	2	13	13	NUM
admet-36	207	3	]	]	SYM
admet-36	207	4	c.m	c.m	PROPN
admet-36	207	5	.	.	PROPN
admet-36	207	6	wassvik	wassvik	PROPN
admet-36	207	7	,	,	PUNCT
admet-36	207	8	a.g	a.g	PROPN
admet-36	207	9	.	.	PROPN
admet-36	207	10	holmén	holmén	PROPN
admet-36	207	11	,	,	PUNCT
admet-36	207	12	c.a.s	c.a.	VERB
admet-36	207	13	.	.	PROPN
admet-36	207	14	bergström	bergström	PROPN
admet-36	207	15	,	,	PUNCT
admet-36	207	16	i.	i.	PROPN
admet-36	207	17	zamora	zamora	PROPN
admet-36	207	18	,	,	PUNCT
admet-36	207	19	p.	p.	PROPN
admet-36	207	20	artursson	artursson	PROPN
admet-36	207	21	,	,	PUNCT
admet-36	207	22	,	,	PUNCT
admet-36	207	23	european	european	PROPN
admet-36	207	24	journal	journal	PROPN
admet-36	207	25	of	of	ADP
admet-36	207	26	pharmaceutical	pharmaceutical	PROPN
admet-36	207	27	sciences	science	NOUN
admet-36	207	28	29	29	NUM
admet-36	207	29	(	(	PUNCT
admet-36	207	30	2006	2006	NUM
admet-36	207	31	)	)	PUNCT
admet-36	207	32	294	294	NUM
admet-36	207	33	-	-	SYM
admet-36	207	34	305	305	NUM
admet-36	208	1	[	[	X
admet-36	208	2	14	14	NUM
admet-36	208	3	]	]	PUNCT
admet-36	208	4	t.	t.	PROPN
admet-36	208	5	suzuki	suzuki	PROPN
admet-36	208	6	,	,	PUNCT
admet-36	208	7	journal	journal	NOUN
admet-36	208	8	of	of	ADP
admet-36	208	9	computer	computer	NOUN
admet-36	208	10	-	-	PUNCT
admet-36	208	11	aided	aid	VERB
admet-36	208	12	molecular	molecular	ADJ
admet-36	208	13	design	design	NOUN
admet-36	208	14	5	5	NUM
admet-36	208	15	(	(	PUNCT
admet-36	208	16	1991	1991	NUM
admet-36	208	17	)	)	PUNCT
admet-36	208	18	149	149	NUM
admet-36	208	19	-	-	SYM
admet-36	208	20	166	166	NUM
admet-36	208	21	[	[	X
admet-36	208	22	15	15	NUM
admet-36	208	23	]	]	X
admet-36	208	24	f.	f.	NOUN
admet-36	208	25	lovering	lovering	PROPN
admet-36	208	26	,	,	PUNCT
admet-36	208	27	j.	j.	PROPN
admet-36	208	28	bikker	bikker	PROPN
admet-36	208	29	,	,	PUNCT
admet-36	208	30	c.	c.	PROPN
admet-36	208	31	humblet	humblet	PROPN
admet-36	208	32	,	,	PUNCT
admet-36	208	33	journal	journal	NOUN
admet-36	208	34	of	of	ADP
admet-36	208	35	medicinal	medicinal	ADJ
admet-36	208	36	chemistry	chemistry	NOUN
admet-36	208	37	52	52	NUM
admet-36	208	38	(	(	PUNCT
admet-36	208	39	2009	2009	NUM
admet-36	208	40	)	)	PUNCT
admet-36	208	41	6752	6752	NUM
admet-36	208	42	-	-	SYM
admet-36	208	43	6756	6756	NUM
admet-36	209	1	[	[	X
admet-36	209	2	16	16	NUM
admet-36	209	3	]	]	PUNCT
admet-36	209	4	m.	m.	NOUN
admet-36	209	5	ishikawa	ishikawa	PROPN
admet-36	209	6	,	,	PUNCT
admet-36	209	7	y.	y.	PROPN
admet-36	209	8	hashimoto	hashimoto	PROPN
admet-36	209	9	,	,	PUNCT
admet-36	209	10	journal	journal	NOUN
admet-36	209	11	of	of	ADP
admet-36	209	12	medicinal	medicinal	ADJ
admet-36	209	13	chemistry	chemistry	NOUN
admet-36	209	14	54	54	NUM
admet-36	209	15	(	(	PUNCT
admet-36	209	16	2011	2011	NUM
admet-36	209	17	)	)	PUNCT
admet-36	209	18	1539	1539	NUM
admet-36	209	19	-	-	SYM
admet-36	209	20	1554	1554	NUM
admet-36	209	21	[	[	X
admet-36	209	22	17	17	NUM
admet-36	209	23	]	]	PUNCT
admet-36	209	24	c.a.s	c.a.s	PROPN
admet-36	209	25	.	.	PROPN
admet-36	209	26	bergström	bergström	PROPN
admet-36	209	27	,	,	PUNCT
admet-36	209	28	c.m	c.m	PROPN
admet-36	209	29	.	.	PROPN
admet-36	209	30	wassvik	wassvik	PROPN
admet-36	209	31	,	,	PUNCT
admet-36	209	32	k.	k.	PROPN
admet-36	209	33	johansson	johansson	PROPN
admet-36	209	34	,	,	PUNCT
admet-36	209	35	i.	i.	PROPN
admet-36	209	36	hubatsch	hubatsch	PROPN
admet-36	209	37	,	,	PUNCT
admet-36	209	38	journal	journal	NOUN
admet-36	209	39	of	of	ADP
admet-36	209	40	medicinal	medicinal	ADJ
admet-36	209	41	chemistry	chemistry	NOUN
admet-36	209	42	50	50	NUM
admet-36	209	43	(	(	PUNCT
admet-36	209	44	2007	2007	NUM
admet-36	209	45	)	)	PUNCT
admet-36	209	46	5858	5858	NUM
admet-36	209	47	-	-	SYM
admet-36	209	48	5862	5862	NUM
admet-36	209	49	[	[	X
admet-36	209	50	18	18	NUM
admet-36	209	51	]	]	X
admet-36	209	52	l.	l.	PROPN
admet-36	209	53	infantes	infantes	PROPN
admet-36	209	54	,	,	PUNCT
admet-36	209	55	l.	l.	PROPN
admet-36	209	56	fabian	fabian	PROPN
admet-36	209	57	,	,	PUNCT
admet-36	209	58	w.d.s	w.d.s	PROPN
admet-36	209	59	.	.	PUNCT
admet-36	210	1	motherwell	motherwell	PROPN
admet-36	210	2	,	,	PUNCT
admet-36	210	3	crystengcomm	crystengcomm	NOUN
admet-36	210	4	9	9	NUM
admet-36	210	5	(	(	PUNCT
admet-36	210	6	2007	2007	NUM
admet-36	210	7	)	)	PUNCT
admet-36	210	8	65	65	NUM
admet-36	210	9	-	-	SYM
admet-36	210	10	71	71	NUM
admet-36	210	11	©	©	PROPN
admet-36	210	12	2014	2014	NUM
admet-36	210	13	by	by	ADP
admet-36	210	14	the	the	DET
admet-36	210	15	authors	author	NOUN
admet-36	210	16	;	;	PUNCT
admet-36	210	17	licensee	licensee	PROPN
admet-36	210	18	iapc	iapc	PROPN
admet-36	210	19	,	,	PUNCT
admet-36	210	20	zagreb	zagreb	PROPN
admet-36	210	21	,	,	PUNCT
admet-36	210	22	croatia	croatia	PROPN
admet-36	210	23	.	.	PUNCT
admet-36	211	1	this	this	DET
admet-36	211	2	article	article	NOUN
admet-36	211	3	is	be	AUX
admet-36	211	4	an	an	DET
admet-36	211	5	open	open	ADJ
admet-36	211	6	-	-	PUNCT
admet-36	211	7	access	access	NOUN
admet-36	211	8	article	article	NOUN
admet-36	211	9	distributed	distribute	VERB
admet-36	211	10	under	under	ADP
admet-36	211	11	the	the	DET
admet-36	211	12	terms	term	NOUN
admet-36	211	13	and	and	CCONJ
admet-36	211	14	conditions	condition	NOUN
admet-36	211	15	of	of	ADP
admet-36	211	16	the	the	DET
admet-36	211	17	creative	creative	ADJ
admet-36	211	18	commons	common	NOUN
admet-36	211	19	attribution	attribution	NOUN
admet-36	211	20	license	license	NOUN
admet-36	211	21	(	(	PUNCT
admet-36	211	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-36	211	23	)	)	PUNCT
admet-36	211	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN