id	sid	tid	token	lemma	pos
admet-373	1	1	manuscript	manuscript	PROPN
admet-373	1	2	doi	doi	PROPN
admet-373	1	3	:	:	PUNCT
admet-373	1	4	10.5599	10.5599	NUM
admet-373	1	5	/	/	SYM
admet-373	1	6	admet.5.1.373	admet.5.1.373	PROPN
admet-373	1	7	14	14	NUM
admet-373	1	8	admet	admet	X
admet-373	1	9	&	&	CCONJ
admet-373	1	10	dmpk	dmpk	PROPN
admet-373	1	11	5(1	5(1	NUM
admet-373	1	12	)	)	PUNCT
admet-373	1	13	(	(	PUNCT
admet-373	1	14	2017	2017	NUM
admet-373	1	15	)	)	PUNCT
admet-373	1	16	14	14	NUM
admet-373	1	17	-	-	SYM
admet-373	1	18	38	38	NUM
admet-373	1	19	;	;	PUNCT
admet-373	1	20	doi	doi	NOUN
admet-373	1	21	:	:	PUNCT
admet-373	1	22	10.5599	10.5599	NUM
admet-373	1	23	/	/	SYM
admet-373	1	24	admet.5.1.373	admet.5.1.373	ADP
admet-373	1	25	open	open	ADJ
admet-373	1	26	access	access	NOUN
admet-373	1	27	:	:	PUNCT
admet-373	1	28	issn	issn	PROPN
admet-373	1	29	:	:	PUNCT
admet-373	1	30	1848	1848	NUM
admet-373	1	31	-	-	SYM
admet-373	1	32	7718	7718	NUM
admet-373	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-373	1	34	original	original	ADJ
admet-373	1	35	scientific	scientific	ADJ
admet-373	1	36	paper	paper	NOUN
admet-373	1	37	in	in	ADP
admet-373	1	38	vitro	vitro	X
admet-373	1	39	membrane	membrane	NOUN
admet-373	1	40	binding	bind	VERB
admet-373	1	41	and	and	CCONJ
admet-373	1	42	protein	protein	NOUN
admet-373	1	43	binding	bind	VERB
admet-373	1	44	(	(	PUNCT
admet-373	1	45	iam	iam	PROPN
admet-373	1	46	mb	mb	PROPN
admet-373	1	47	/	/	SYM
admet-373	1	48	pb	pb	X
admet-373	1	49	technology	technology	NOUN
admet-373	1	50	)	)	PUNCT
admet-373	1	51	to	to	PART
admet-373	1	52	estimate	estimate	VERB
admet-373	1	53	in	in	ADP
admet-373	1	54	vivo	vivo	ADJ
admet-373	1	55	distribution	distribution	NOUN
admet-373	1	56	:	:	PUNCT
admet-373	1	57	applications	application	NOUN
admet-373	1	58	in	in	ADP
admet-373	1	59	early	early	ADJ
admet-373	1	60	drug	drug	NOUN
admet-373	1	61	discovery	discovery	PROPN
admet-373	1	62	klara	klara	PROPN
admet-373	1	63	valko*1	valko*1	PROPN
admet-373	1	64	,	,	PUNCT
admet-373	1	65	simon	simon	PROPN
admet-373	1	66	teague2	teague2	PROPN
admet-373	1	67	,	,	PUNCT
admet-373	1	68	and	and	CCONJ
admet-373	1	69	charles	charles	PROPN
admet-373	1	70	pidgeon3	pidgeon3	PROPN
admet-373	1	71	1	1	NUM
admet-373	1	72	bio	bio	ADJ
admet-373	1	73	-	-	ADJ
admet-373	1	74	mimetic	mimetic	ADJ
admet-373	1	75	chromatography	chromatography	NOUN
admet-373	1	76	,	,	PUNCT
admet-373	1	77	unit	unit	NOUN
admet-373	1	78	5b	5b	PROPN
admet-373	1	79	business	business	NOUN
admet-373	1	80	&	&	CCONJ
admet-373	1	81	technology	technology	PROPN
admet-373	1	82	centre	centre	PROPN
admet-373	1	83	,	,	PUNCT
admet-373	1	84	stevenage	stevenage	PROPN
admet-373	1	85	,	,	PUNCT
admet-373	1	86	sg1	sg1	PROPN
admet-373	1	87	2dx	2dx	PROPN
admet-373	1	88	hertfordshire	hertfordshire	PROPN
admet-373	1	89	united	united	PROPN
admet-373	1	90	kingdom	kingdom	PROPN
admet-373	1	91	2	2	NUM
admet-373	1	92	glaxosmithkline	glaxosmithkline	PROPN
admet-373	1	93	,	,	PUNCT
admet-373	1	94	stevenage	stevenage	PROPN
admet-373	1	95	,	,	PUNCT
admet-373	1	96	united	united	ADJ
admet-373	1	97	kingdom	kingdom	PROPN
admet-373	1	98	3	3	NUM
admet-373	1	99	independent	independent	ADJ
admet-373	1	100	researcher	researcher	NOUN
admet-373	1	101	,	,	PUNCT
admet-373	1	102	affiliate	affiliate	NOUN
admet-373	1	103	of	of	ADP
admet-373	1	104	regis	regis	PROPN
admet-373	1	105	technologies	technologies	PROPN
admet-373	1	106	inc	inc	PROPN
admet-373	1	107	,	,	PUNCT
admet-373	1	108	morton	morton	PROPN
admet-373	1	109	grove	grove	PROPN
admet-373	1	110	,	,	PUNCT
admet-373	1	111	il	il	PROPN
admet-373	1	112	60052	60052	NUM
admet-373	1	113	usa	usa	PROPN
admet-373	1	114	*	*	PUNCT
admet-373	1	115	corresponding	correspond	VERB
admet-373	1	116	author	author	NOUN
admet-373	1	117	:	:	PUNCT
admet-373	1	118	e	e	NOUN
admet-373	1	119	-	-	NOUN
admet-373	1	120	mail	mail	NOUN
admet-373	1	121	:	:	PUNCT
admet-373	1	122	klara_valko@bio-mimetic-chromatography.com	klara_valko@bio-mimetic-chromatography.com	NOUN
admet-373	1	123	;	;	PUNCT
admet-373	1	124	tel	tel	PROPN
admet-373	1	125	.	.	PUNCT
admet-373	1	126	:	:	PUNCT
admet-373	2	1	+44	+44	PROPN
admet-373	2	2	-	-	SYM
admet-373	2	3	7521989558	7521989558	NUM
admet-373	2	4	;	;	PUNCT
admet-373	2	5	received	receive	VERB
admet-373	2	6	:	:	PUNCT
admet-373	2	7	february	february	PROPN
admet-373	2	8	07	07	NUM
admet-373	2	9	,	,	PUNCT
admet-373	2	10	2017	2017	NUM
admet-373	2	11	;	;	PUNCT
admet-373	2	12	revised	revise	VERB
admet-373	2	13	:	:	PUNCT
admet-373	2	14	march	march	PROPN
admet-373	2	15	14	14	NUM
admet-373	2	16	,	,	PUNCT
admet-373	2	17	2017	2017	NUM
admet-373	2	18	;	;	PUNCT
admet-373	2	19	published	publish	VERB
admet-373	2	20	:	:	PUNCT
admet-373	2	21	march	march	PROPN
admet-373	2	22	25	25	NUM
admet-373	2	23	,	,	PUNCT
admet-373	2	24	2017	2017	NUM
admet-373	2	25	abstract	abstract	ADV
admet-373	2	26	the	the	DET
admet-373	2	27	drug	drug	NOUN
admet-373	2	28	discovery	discovery	NOUN
admet-373	2	29	process	process	NOUN
admet-373	2	30	can	can	AUX
admet-373	2	31	be	be	AUX
admet-373	2	32	accelerated	accelerate	VERB
admet-373	2	33	by	by	ADP
admet-373	2	34	chromatographic	chromatographic	ADJ
admet-373	2	35	profiling	profiling	NOUN
admet-373	2	36	of	of	ADP
admet-373	2	37	the	the	DET
admet-373	2	38	analogs	analog	NOUN
admet-373	2	39	to	to	PART
admet-373	2	40	model	model	VERB
admet-373	2	41	in	in	ADP
admet-373	2	42	vivo	vivo	ADJ
admet-373	2	43	distribution	distribution	NOUN
admet-373	2	44	and	and	CCONJ
admet-373	2	45	the	the	DET
admet-373	2	46	major	major	ADJ
admet-373	2	47	non	non	ADJ
admet-373	2	48	-	-	ADJ
admet-373	2	49	specific	specific	ADJ
admet-373	2	50	binding	binding	NOUN
admet-373	2	51	.	.	PUNCT
admet-373	3	1	a	a	DET
admet-373	3	2	balanced	balanced	ADJ
admet-373	3	3	potency	potency	NOUN
admet-373	3	4	and	and	CCONJ
admet-373	3	5	chromatographically	chromatographically	ADV
admet-373	3	6	determined	determine	VERB
admet-373	3	7	membrane	membrane	NOUN
admet-373	3	8	and	and	CCONJ
admet-373	3	9	protein	protein	NOUN
admet-373	3	10	binding	bind	VERB
admet-373	3	11	(	(	PUNCT
admet-373	3	12	iam	iam	PROPN
admet-373	3	13	mb	mb	PROPN
admet-373	3	14	/	/	SYM
admet-373	3	15	pb	pb	NOUN
admet-373	3	16	)	)	PUNCT
admet-373	3	17	data	datum	NOUN
admet-373	3	18	enable	enable	VERB
admet-373	3	19	selecting	select	VERB
admet-373	3	20	drug	drug	NOUN
admet-373	3	21	discovery	discovery	NOUN
admet-373	3	22	compounds	compound	NOUN
admet-373	3	23	for	for	ADP
admet-373	3	24	further	further	ADJ
admet-373	3	25	analysis	analysis	NOUN
admet-373	3	26	that	that	PRON
admet-373	3	27	have	have	VERB
admet-373	3	28	the	the	DET
admet-373	3	29	highest	high	ADJ
admet-373	3	30	probability	probability	NOUN
admet-373	3	31	to	to	PART
admet-373	3	32	show	show	VERB
admet-373	3	33	the	the	DET
admet-373	3	34	desired	desire	VERB
admet-373	3	35	in	in	ADP
admet-373	3	36	vivo	vivo	ADJ
admet-373	3	37	distribution	distribution	NOUN
admet-373	3	38	behavior	behavior	NOUN
admet-373	3	39	for	for	ADP
admet-373	3	40	efficacy	efficacy	NOUN
admet-373	3	41	and	and	CCONJ
admet-373	3	42	reduced	reduce	VERB
admet-373	3	43	chance	chance	NOUN
admet-373	3	44	for	for	ADP
admet-373	3	45	toxicity	toxicity	NOUN
admet-373	3	46	.	.	PUNCT
admet-373	4	1	although	although	SCONJ
admet-373	4	2	the	the	DET
admet-373	4	3	basic	basic	ADJ
admet-373	4	4	principles	principle	NOUN
admet-373	4	5	of	of	ADP
admet-373	4	6	the	the	DET
admet-373	4	7	technology	technology	NOUN
admet-373	4	8	have	have	AUX
admet-373	4	9	already	already	ADV
admet-373	4	10	appeared	appear	VERB
admet-373	4	11	in	in	ADP
admet-373	4	12	numerous	numerous	ADJ
admet-373	4	13	publications	publication	NOUN
admet-373	4	14	,	,	PUNCT
admet-373	4	15	the	the	DET
admet-373	4	16	lack	lack	NOUN
admet-373	4	17	of	of	ADP
admet-373	4	18	standardized	standardized	ADJ
admet-373	4	19	procedures	procedure	NOUN
admet-373	4	20	limited	limit	VERB
admet-373	4	21	its	its	PRON
admet-373	4	22	widespread	widespread	ADJ
admet-373	4	23	applications	application	NOUN
admet-373	4	24	especially	especially	ADV
admet-373	4	25	in	in	ADP
admet-373	4	26	academia	academia	NOUN
admet-373	4	27	and	and	CCONJ
admet-373	4	28	small	small	ADJ
admet-373	4	29	drug	drug	NOUN
admet-373	4	30	discovery	discovery	NOUN
admet-373	4	31	biotech	biotech	NOUN
admet-373	4	32	companies	company	NOUN
admet-373	4	33	.	.	PUNCT
admet-373	5	1	in	in	ADP
admet-373	5	2	this	this	DET
admet-373	5	3	paper	paper	NOUN
admet-373	5	4	,	,	PUNCT
admet-373	5	5	the	the	DET
admet-373	5	6	standardized	standardized	ADJ
admet-373	5	7	procedures	procedure	NOUN
admet-373	5	8	are	be	AUX
admet-373	5	9	described	describe	VERB
admet-373	5	10	that	that	PRON
admet-373	5	11	has	have	AUX
admet-373	5	12	been	be	AUX
admet-373	5	13	trademarked	trademark	VERB
admet-373	5	14	as	as	ADP
admet-373	5	15	regis	regis	PROPN
admet-373	5	16	iam	iam	PROPN
admet-373	5	17	mb	mb	PROPN
admet-373	5	18	/	/	SYM
admet-373	5	19	pb	pb	ADP
admet-373	5	20	technology	technology	NOUN
admet-373	5	21	®	®	PROPN
admet-373	5	22	.	.	PUNCT
admet-373	6	1	comparison	comparison	NOUN
admet-373	6	2	between	between	ADP
admet-373	6	3	the	the	DET
admet-373	6	4	drug	drug	NOUN
admet-373	6	5	efficiency	efficiency	NOUN
admet-373	6	6	index	index	NOUN
admet-373	6	7	(	(	PUNCT
admet-373	6	8	dei	dei	NOUN
admet-373	6	9	=	=	NOUN
admet-373	6	10	pic50	pic50	NOUN
admet-373	6	11	-	-	PUNCT
admet-373	6	12	logvdu+2	logvdu+2	NOUN
admet-373	6	13	)	)	PUNCT
admet-373	6	14	and	and	CCONJ
admet-373	6	15	generally	generally	ADV
admet-373	6	16	used	use	VERB
admet-373	6	17	ligand	ligand	NOUN
admet-373	6	18	lipophilicity	lipophilicity	NOUN
admet-373	6	19	efficiency	efficiency	NOUN
admet-373	6	20	(	(	PUNCT
admet-373	6	21	lle	lle	PROPN
admet-373	6	22	)	)	PUNCT
admet-373	6	23	has	have	AUX
admet-373	6	24	been	be	AUX
admet-373	6	25	made	make	VERB
admet-373	6	26	,	,	PUNCT
admet-373	6	27	demonstrating	demonstrate	VERB
admet-373	6	28	the	the	DET
admet-373	6	29	advantage	advantage	NOUN
admet-373	6	30	of	of	ADP
admet-373	6	31	measured	measure	VERB
admet-373	6	32	iam	iam	PROPN
admet-373	6	33	and	and	CCONJ
admet-373	6	34	hsa	hsa	AUX
admet-373	6	35	binding	bind	VERB
admet-373	6	36	over	over	ADP
admet-373	6	37	calculated	calculate	VERB
admet-373	6	38	log	log	NOUN
admet-373	6	39	p.	p.	NOUN
admet-373	6	40	the	the	DET
admet-373	6	41	power	power	NOUN
admet-373	6	42	of	of	ADP
admet-373	6	43	the	the	DET
admet-373	6	44	proposed	propose	VERB
admet-373	6	45	chromatographic	chromatographic	ADJ
admet-373	6	46	technology	technology	NOUN
admet-373	6	47	is	be	AUX
admet-373	6	48	demonstrated	demonstrate	VERB
admet-373	6	49	using	use	VERB
admet-373	6	50	the	the	DET
admet-373	6	51	data	datum	NOUN
admet-373	6	52	of	of	ADP
admet-373	6	53	marketed	market	VERB
admet-373	6	54	drugs	drug	NOUN
admet-373	6	55	.	.	PUNCT
admet-373	7	1	keywords	keyword	VERB
admet-373	7	2	drug	drug	NOUN
admet-373	7	3	efficiency	efficiency	NOUN
admet-373	7	4	;	;	PUNCT
admet-373	7	5	biomimetic	biomimetic	ADJ
admet-373	7	6	properties	property	NOUN
admet-373	7	7	by	by	ADP
admet-373	7	8	hplc	hplc	NOUN
admet-373	7	9	;	;	PUNCT
admet-373	7	10	unbound	unbound	NOUN
admet-373	7	11	volume	volume	NOUN
admet-373	7	12	of	of	ADP
admet-373	7	13	distribution	distribution	NOUN
admet-373	7	14	;	;	PUNCT
admet-373	7	15	in	in	ADP
admet-373	7	16	vivo	vivo	ADJ
admet-373	7	17	distribution	distribution	NOUN
admet-373	7	18	introduction	introduction	NOUN
admet-373	7	19	medicinal	medicinal	ADJ
admet-373	7	20	chemists	chemist	NOUN
admet-373	7	21	face	face	VERB
admet-373	7	22	multi	multi	ADJ
admet-373	7	23	-	-	ADJ
admet-373	7	24	factorial	factorial	ADJ
admet-373	7	25	challenge	challenge	NOUN
admet-373	7	26	problems	problem	NOUN
admet-373	7	27	when	when	SCONJ
admet-373	7	28	designing	design	VERB
admet-373	7	29	drug	drug	NOUN
admet-373	7	30	molecules	molecule	NOUN
admet-373	7	31	that	that	PRON
admet-373	7	32	can	can	AUX
admet-373	7	33	reduce	reduce	VERB
admet-373	7	34	the	the	DET
admet-373	7	35	impact	impact	NOUN
admet-373	7	36	or	or	CCONJ
admet-373	7	37	cure	cure	VERB
admet-373	7	38	a	a	DET
admet-373	7	39	pathological	pathological	ADJ
admet-373	7	40	condition	condition	NOUN
admet-373	7	41	;	;	PUNCT
admet-373	7	42	drug	drug	NOUN
admet-373	7	43	discovery	discovery	NOUN
admet-373	7	44	scientists	scientist	NOUN
admet-373	7	45	seek	seek	VERB
admet-373	7	46	the	the	DET
admet-373	7	47	smallest	small	ADJ
admet-373	7	48	possible	possible	ADJ
admet-373	7	49	dose	dose	NOUN
admet-373	7	50	with	with	ADP
admet-373	7	51	minimal	minimal	ADJ
admet-373	7	52	side	side	NOUN
admet-373	7	53	effects	effect	NOUN
admet-373	7	54	[	[	X
admet-373	7	55	1	1	NUM
admet-373	7	56	-	-	SYM
admet-373	7	57	4	4	NUM
admet-373	7	58	]	]	PUNCT
admet-373	7	59	.	.	PUNCT
admet-373	8	1	screening	screen	VERB
admet-373	8	2	cascades	cascade	NOUN
admet-373	8	3	often	often	ADV
admet-373	8	4	generate	generate	VERB
admet-373	8	5	vast	vast	ADJ
admet-373	8	6	quantities	quantity	NOUN
admet-373	8	7	of	of	ADP
admet-373	8	8	primarily	primarily	ADV
admet-373	8	9	in	in	ADP
admet-373	8	10	-	-	PUNCT
admet-373	8	11	vitro	vitro	X
admet-373	8	12	data	datum	NOUN
admet-373	8	13	,	,	PUNCT
admet-373	8	14	and	and	CCONJ
admet-373	8	15	in	in	ADP
admet-373	8	16	some	some	DET
admet-373	8	17	cases	case	NOUN
admet-373	8	18	,	,	PUNCT
admet-373	8	19	in	in	ADP
admet-373	8	20	vivo	vivo	ADJ
admet-373	8	21	data	datum	NOUN
admet-373	8	22	on	on	ADP
admet-373	8	23	compounds	compound	NOUN
admet-373	8	24	that	that	PRON
admet-373	8	25	form	form	VERB
admet-373	8	26	a	a	DET
admet-373	8	27	decision	decision	NOUN
admet-373	8	28	on	on	ADP
admet-373	8	29	which	which	PRON
admet-373	8	30	compounds	compound	NOUN
admet-373	8	31	are	be	AUX
admet-373	8	32	selected	select	VERB
admet-373	8	33	for	for	ADP
admet-373	8	34	further	further	ADJ
admet-373	8	35	progression	progression	NOUN
admet-373	8	36	.	.	PUNCT
admet-373	9	1	this	this	DET
admet-373	9	2	paper	paper	NOUN
admet-373	9	3	documents	document	VERB
admet-373	9	4	an	an	DET
admet-373	9	5	alternative	alternative	ADJ
admet-373	9	6	screening	screening	NOUN
admet-373	9	7	triage	triage	NOUN
admet-373	9	8	which	which	PRON
admet-373	9	9	can	can	AUX
admet-373	9	10	help	help	VERB
admet-373	9	11	to	to	PART
admet-373	9	12	avoid	avoid	VERB
admet-373	9	13	the	the	DET
admet-373	9	14	problem	problem	NOUN
admet-373	9	15	of	of	ADP
admet-373	9	16	analysing	analyse	VERB
admet-373	9	17	too	too	ADV
admet-373	9	18	much	much	ADJ
admet-373	9	19	discovery	discovery	NOUN
admet-373	9	20	data	datum	NOUN
admet-373	9	21	when	when	SCONJ
admet-373	9	22	choosing	choose	VERB
admet-373	9	23	lead	lead	NOUN
admet-373	9	24	compounds	compound	NOUN
admet-373	9	25	to	to	PART
admet-373	9	26	pursue	pursue	VERB
admet-373	9	27	.	.	PUNCT
admet-373	10	1	chemical	chemical	NOUN
admet-373	10	2	structure	structure	NOUN
admet-373	10	3	design	design	NOUN
admet-373	10	4	of	of	ADP
admet-373	10	5	discovery	discovery	NOUN
admet-373	10	6	molecules	molecule	NOUN
admet-373	10	7	usually	usually	ADV
admet-373	10	8	focuses	focus	VERB
admet-373	10	9	on	on	ADP
admet-373	10	10	elucidating	elucidate	VERB
admet-373	10	11	the	the	DET
admet-373	10	12	structure	structure	NOUN
admet-373	10	13	–	–	PUNCT
admet-373	10	14	activity	activity	NOUN
admet-373	10	15	relationships	relationship	NOUN
admet-373	10	16	after	after	ADP
admet-373	10	17	identifying	identify	VERB
admet-373	10	18	the	the	DET
admet-373	10	19	target	target	NOUN
admet-373	10	20	enzyme	enzyme	NOUN
admet-373	10	21	/	/	SYM
admet-373	10	22	receptor	receptor	NOUN
admet-373	10	23	followed	follow	VERB
admet-373	10	24	by	by	ADP
admet-373	10	25	the	the	DET
admet-373	10	26	development	development	NOUN
admet-373	10	27	of	of	ADP
admet-373	10	28	a	a	DET
admet-373	10	29	potency	potency	NOUN
admet-373	10	30	screening	screen	VERB
admet-373	10	31	method	method	NOUN
admet-373	10	32	.	.	PUNCT
admet-373	11	1	the	the	DET
admet-373	11	2	active	active	ADJ
admet-373	11	3	molecules	molecule	NOUN
admet-373	11	4	are	be	AUX
admet-373	11	5	then	then	ADV
admet-373	11	6	tested	test	VERB
admet-373	11	7	for	for	ADP
admet-373	11	8	a	a	DET
admet-373	11	9	variety	variety	NOUN
admet-373	11	10	of	of	ADP
admet-373	11	11	assays	assay	NOUN
admet-373	11	12	for	for	ADP
admet-373	11	13	affinity	affinity	NOUN
admet-373	11	14	and	and	CCONJ
admet-373	11	15	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-373	11	16	mailto:name@address.domain	mailto:name@address.domain	PROPN
admet-373	11	17	admet	admet	PROPN
admet-373	11	18	&	&	CCONJ
admet-373	11	19	dmpk	dmpk	PROPN
admet-373	11	20	5(1	5(1	NUM
admet-373	11	21	)	)	PUNCT
admet-373	11	22	(	(	PUNCT
admet-373	11	23	2017	2017	NUM
admet-373	11	24	)	)	PUNCT
admet-373	11	25	14	14	NUM
admet-373	11	26	-	-	SYM
admet-373	11	27	38	38	NUM
admet-373	11	28	in	in	ADP
admet-373	11	29	vitro	vitro	X
admet-373	11	30	membrane	membrane	NOUN
admet-373	11	31	and	and	CCONJ
admet-373	11	32	protein	protein	NOUN
admet-373	11	33	binding	bind	VERB
admet-373	11	34	doi	doi	NOUN
admet-373	11	35	:	:	PUNCT
admet-373	11	36	10.5599	10.5599	NUM
admet-373	11	37	/	/	SYM
admet-373	11	38	admet.5.1.373	admet.5.1.373	NUM
admet-373	11	39	15	15	NUM
admet-373	11	40	developability	developability	NOUN
admet-373	11	41	,	,	PUNCT
admet-373	11	42	such	such	ADJ
admet-373	11	43	as	as	ADP
admet-373	11	44	enzyme	enzyme	NOUN
admet-373	11	45	assays	assay	NOUN
admet-373	11	46	,	,	PUNCT
admet-373	11	47	selectivity	selectivity	NOUN
admet-373	11	48	assays	assay	NOUN
admet-373	11	49	,	,	PUNCT
admet-373	11	50	cellular	cellular	ADJ
admet-373	11	51	assays	assay	NOUN
admet-373	11	52	,	,	PUNCT
admet-373	11	53	caco2	caco2	NOUN
admet-373	11	54	or	or	CCONJ
admet-373	11	55	mdck	mdck	PROPN
admet-373	11	56	cell	cell	NOUN
admet-373	11	57	permeability	permeability	NOUN
admet-373	11	58	,	,	PUNCT
admet-373	11	59	solubility	solubility	NOUN
admet-373	11	60	[	[	X
admet-373	11	61	5	5	NUM
admet-373	11	62	]	]	PUNCT
admet-373	11	63	,	,	PUNCT
admet-373	11	64	lipophilicity	lipophilicity	NOUN
admet-373	11	65	,	,	PUNCT
admet-373	11	66	microsomal	microsomal	ADJ
admet-373	11	67	stability	stability	NOUN
admet-373	11	68	,	,	PUNCT
admet-373	11	69	hep	hep	NOUN
admet-373	11	70	g	g	PROPN
admet-373	11	71	cell	cell	NOUN
admet-373	11	72	hepatotoxicity	hepatotoxicity	NOUN
admet-373	11	73	,	,	PUNCT
admet-373	11	74	cellular	cellular	ADJ
admet-373	11	75	toxicity	toxicity	NOUN
admet-373	11	76	,	,	PUNCT
admet-373	11	77	[	[	X
admet-373	11	78	6	6	NUM
admet-373	11	79	]	]	PUNCT
admet-373	11	80	etc	etc	X
admet-373	11	81	.	.	X
admet-373	12	1	all	all	DET
admet-373	12	2	future	future	ADJ
admet-373	12	3	reference	reference	NOUN
admet-373	12	4	to	to	ADP
admet-373	12	5	receptors	receptor	NOUN
admet-373	12	6	will	will	AUX
admet-373	12	7	have	have	VERB
admet-373	12	8	dual	dual	ADJ
admet-373	12	9	meaning	meaning	NOUN
admet-373	12	10	referring	refer	VERB
admet-373	12	11	to	to	ADP
admet-373	12	12	either	either	CCONJ
admet-373	12	13	receptor	receptor	NOUN
admet-373	12	14	or	or	CCONJ
admet-373	12	15	enzyme	enzyme	NOUN
admet-373	12	16	targets	target	NOUN
admet-373	12	17	,	,	PUNCT
admet-373	12	18	for	for	ADP
admet-373	12	19	simplicity	simplicity	NOUN
admet-373	12	20	.	.	PUNCT
admet-373	13	1	project	project	NOUN
admet-373	13	2	teams	team	NOUN
admet-373	13	3	usually	usually	ADV
admet-373	13	4	design	design	VERB
admet-373	13	5	screening	screen	VERB
admet-373	13	6	cascades	cascade	NOUN
admet-373	13	7	to	to	PART
admet-373	13	8	guide	guide	VERB
admet-373	13	9	the	the	DET
admet-373	13	10	filtering	filter	VERB
admet-373	13	11	process	process	NOUN
admet-373	13	12	of	of	ADP
admet-373	13	13	compounds	compound	NOUN
admet-373	13	14	after	after	ADP
admet-373	13	15	each	each	DET
admet-373	13	16	measurement	measurement	NOUN
admet-373	13	17	,	,	PUNCT
admet-373	13	18	to	to	PART
admet-373	13	19	ensure	ensure	VERB
admet-373	13	20	those	those	DET
admet-373	13	21	compounds	compound	NOUN
admet-373	13	22	that	that	PRON
admet-373	13	23	do	do	AUX
admet-373	13	24	not	not	PART
admet-373	13	25	meet	meet	VERB
admet-373	13	26	pre	pre	ADJ
admet-373	13	27	-	-	ADJ
admet-373	13	28	defined	define	VERB
admet-373	13	29	criteria	criterion	NOUN
admet-373	13	30	in	in	ADP
admet-373	13	31	a	a	DET
admet-373	13	32	particular	particular	ADJ
admet-373	13	33	assay	assay	NOUN
admet-373	13	34	are	be	AUX
admet-373	13	35	eliminated	eliminate	VERB
admet-373	13	36	from	from	ADP
admet-373	13	37	further	further	ADJ
admet-373	13	38	screening	screening	NOUN
admet-373	13	39	.	.	PUNCT
admet-373	14	1	this	this	DET
admet-373	14	2	sequential	sequential	ADJ
admet-373	14	3	screening	screening	NOUN
admet-373	14	4	process	process	NOUN
admet-373	14	5	frequently	frequently	ADV
admet-373	14	6	excludes	exclude	VERB
admet-373	14	7	compounds	compound	NOUN
admet-373	14	8	with	with	ADP
admet-373	14	9	good	good	ADJ
admet-373	14	10	in	in	ADP
admet-373	14	11	vivo	vivo	ADJ
admet-373	14	12	drug	drug	NOUN
admet-373	14	13	properties	property	NOUN
admet-373	14	14	;	;	PUNCT
admet-373	14	15	marketed	market	VERB
admet-373	14	16	drugs	drug	NOUN
admet-373	14	17	have	have	VERB
admet-373	14	18	appropriate	appropriate	ADJ
admet-373	14	19	in	in	ADP
admet-373	14	20	vivo	vivo	ADJ
admet-373	14	21	properties	property	NOUN
admet-373	14	22	for	for	ADP
admet-373	14	23	the	the	DET
admet-373	14	24	disease	disease	NOUN
admet-373	14	25	they	they	PRON
admet-373	14	26	are	be	AUX
admet-373	14	27	being	be	AUX
admet-373	14	28	developed	develop	VERB
admet-373	14	29	to	to	PART
admet-373	14	30	treat	treat	VERB
admet-373	14	31	,	,	PUNCT
admet-373	14	32	along	along	ADP
admet-373	14	33	with	with	ADP
admet-373	14	34	sufficient	sufficient	ADJ
admet-373	14	35	potency	potency	NOUN
admet-373	14	36	to	to	PART
admet-373	14	37	engage	engage	VERB
admet-373	14	38	the	the	DET
admet-373	14	39	target	target	NOUN
admet-373	14	40	and	and	CCONJ
admet-373	14	41	produce	produce	VERB
admet-373	14	42	the	the	DET
admet-373	14	43	desired	desire	VERB
admet-373	14	44	effect	effect	NOUN
admet-373	14	45	.	.	PUNCT
admet-373	15	1	the	the	DET
admet-373	15	2	discovery	discovery	NOUN
admet-373	15	3	challenge	challenge	NOUN
admet-373	15	4	is	be	AUX
admet-373	15	5	to	to	PART
admet-373	15	6	recognise	recognise	VERB
admet-373	15	7	that	that	SCONJ
admet-373	15	8	discovery	discovery	NOUN
admet-373	15	9	compounds	compound	NOUN
admet-373	15	10	may	may	AUX
admet-373	15	11	exhibit	exhibit	VERB
admet-373	15	12	high	high	ADJ
admet-373	15	13	potency	potency	NOUN
admet-373	15	14	,	,	PUNCT
admet-373	15	15	but	but	CCONJ
admet-373	15	16	they	they	PRON
admet-373	15	17	may	may	AUX
admet-373	15	18	lack	lack	VERB
admet-373	15	19	acceptable	acceptable	ADJ
admet-373	15	20	in	in	ADP
admet-373	15	21	vivo	vivo	ADJ
admet-373	15	22	distribution	distribution	NOUN
admet-373	15	23	enabling	enable	VERB
admet-373	15	24	the	the	DET
admet-373	15	25	compound	compound	NOUN
admet-373	15	26	to	to	PART
admet-373	15	27	achieve	achieve	VERB
admet-373	15	28	a	a	DET
admet-373	15	29	therapeutic	therapeutic	ADJ
admet-373	15	30	free	free	ADJ
admet-373	15	31	drug	drug	NOUN
admet-373	15	32	concentration	concentration	NOUN
admet-373	15	33	at	at	ADP
admet-373	15	34	the	the	DET
admet-373	15	35	target	target	NOUN
admet-373	15	36	receptor	receptor	NOUN
admet-373	15	37	in	in	ADP
admet-373	15	38	the	the	DET
admet-373	15	39	target	target	NOUN
admet-373	15	40	tissue(s	tissue(s	NOUN
admet-373	15	41	)	)	PUNCT
admet-373	15	42	in	in	ADP
admet-373	15	43	vivo	vivo	NOUN
admet-373	15	44	.	.	PUNCT
admet-373	16	1	in	in	ADP
admet-373	16	2	vivo	vivo	ADJ
admet-373	16	3	properties	property	NOUN
admet-373	16	4	,	,	PUNCT
admet-373	16	5	particularly	particularly	ADV
admet-373	16	6	distribution	distribution	NOUN
admet-373	16	7	,	,	PUNCT
admet-373	16	8	are	be	AUX
admet-373	16	9	as	as	ADV
admet-373	16	10	important	important	ADJ
admet-373	16	11	as	as	ADP
admet-373	16	12	high	high	ADJ
admet-373	16	13	potency	potency	NOUN
admet-373	16	14	or	or	CCONJ
admet-373	16	15	receptor	receptor	NOUN
admet-373	16	16	occupancy	occupancy	NOUN
admet-373	16	17	.	.	PUNCT
admet-373	17	1	regardless	regardless	ADV
admet-373	17	2	of	of	ADP
admet-373	17	3	this	this	DET
admet-373	17	4	fact	fact	NOUN
admet-373	17	5	,	,	PUNCT
admet-373	17	6	none	none	NOUN
admet-373	17	7	of	of	ADP
admet-373	17	8	the	the	DET
admet-373	17	9	properties	property	NOUN
admet-373	17	10	which	which	PRON
admet-373	17	11	are	be	AUX
admet-373	17	12	typically	typically	ADV
admet-373	17	13	measured	measure	VERB
admet-373	17	14	during	during	ADP
admet-373	17	15	compound	compound	NOUN
admet-373	17	16	screening	screening	NOUN
admet-373	17	17	is	be	AUX
admet-373	17	18	on	on	ADP
admet-373	17	19	their	their	PRON
admet-373	17	20	own	own	ADJ
admet-373	17	21	sufficient	sufficient	ADJ
admet-373	17	22	to	to	PART
admet-373	17	23	predict	predict	VERB
admet-373	17	24	the	the	DET
admet-373	17	25	compound	compound	NOUN
admet-373	17	26	’s	’s	PART
admet-373	17	27	fate	fate	NOUN
admet-373	17	28	in	in	ADP
admet-373	17	29	vivo	vivo	NOUN
admet-373	17	30	or	or	CCONJ
admet-373	17	31	in	in	ADP
admet-373	17	32	human	human	ADJ
admet-373	17	33	clinical	clinical	ADJ
admet-373	17	34	trials	trial	NOUN
admet-373	17	35	.	.	PUNCT
admet-373	18	1	this	this	PRON
admet-373	18	2	must	must	AUX
admet-373	18	3	ultimately	ultimately	ADV
admet-373	18	4	be	be	AUX
admet-373	18	5	measured	measure	VERB
admet-373	18	6	.	.	PUNCT
admet-373	19	1	several	several	ADJ
admet-373	19	2	other	other	ADJ
admet-373	19	3	properties	property	NOUN
admet-373	19	4	should	should	AUX
admet-373	19	5	also	also	ADV
admet-373	19	6	be	be	AUX
admet-373	19	7	measured	measure	VERB
admet-373	19	8	,	,	PUNCT
admet-373	19	9	which	which	PRON
admet-373	19	10	include	include	VERB
admet-373	19	11	target	target	NOUN
admet-373	19	12	binding	binding	ADJ
admet-373	19	13	,	,	PUNCT
admet-373	19	14	selectivity	selectivity	NOUN
admet-373	19	15	,	,	PUNCT
admet-373	19	16	absorption	absorption	NOUN
admet-373	19	17	,	,	PUNCT
admet-373	19	18	distribution	distribution	NOUN
admet-373	19	19	,	,	PUNCT
admet-373	19	20	metabolism	metabolism	NOUN
admet-373	19	21	and	and	CCONJ
admet-373	19	22	elimination	elimination	NOUN
admet-373	19	23	(	(	PUNCT
admet-373	19	24	adme	adme	NOUN
admet-373	19	25	)	)	PUNCT
admet-373	19	26	,	,	PUNCT
admet-373	19	27	pharmacokinetics	pharmacokinetic	NOUN
admet-373	19	28	and	and	CCONJ
admet-373	19	29	pharmacodynamics	pharmacodynamic	NOUN
admet-373	19	30	(	(	PUNCT
admet-373	19	31	pk	pk	NOUN
admet-373	19	32	/	/	SYM
admet-373	19	33	pd	pd	NOUN
admet-373	19	34	)	)	PUNCT
admet-373	19	35	profile	profile	NOUN
admet-373	19	36	,	,	PUNCT
admet-373	19	37	and	and	CCONJ
admet-373	19	38	of	of	ADP
admet-373	19	39	course	course	NOUN
admet-373	19	40	the	the	DET
admet-373	19	41	safety	safety	NOUN
admet-373	19	42	profile	profile	NOUN
admet-373	19	43	.	.	PUNCT
admet-373	20	1	in	in	ADP
admet-373	20	2	order	order	NOUN
admet-373	20	3	to	to	PART
admet-373	20	4	find	find	VERB
admet-373	20	5	good	good	ADJ
admet-373	20	6	absorption	absorption	NOUN
admet-373	20	7	and	and	CCONJ
admet-373	20	8	bioavailability	bioavailability	NOUN
admet-373	20	9	,	,	PUNCT
admet-373	20	10	chemists	chemist	NOUN
admet-373	20	11	have	have	VERB
admet-373	20	12	to	to	PART
admet-373	20	13	design	design	VERB
admet-373	20	14	molecules	molecule	NOUN
admet-373	20	15	which	which	PRON
admet-373	20	16	will	will	AUX
admet-373	20	17	have	have	VERB
admet-373	20	18	good	good	ADJ
admet-373	20	19	solubility	solubility	NOUN
admet-373	20	20	and	and	CCONJ
admet-373	20	21	permeability	permeability	NOUN
admet-373	20	22	,	,	PUNCT
admet-373	20	23	and	and	CCONJ
admet-373	20	24	in	in	ADP
admet-373	20	25	general	general	ADJ
admet-373	20	26	lipophilicity	lipophilicity	NOUN
admet-373	20	27	.	.	PUNCT
admet-373	21	1	designing	design	VERB
admet-373	21	2	a	a	DET
admet-373	21	3	drug	drug	NOUN
admet-373	21	4	candidate	candidate	NOUN
admet-373	21	5	which	which	PRON
admet-373	21	6	has	have	VERB
admet-373	21	7	good	good	ADJ
admet-373	21	8	clinical	clinical	ADJ
admet-373	21	9	adme	adme	NOUN
admet-373	21	10	properties	property	NOUN
admet-373	21	11	,	,	PUNCT
admet-373	21	12	is	be	AUX
admet-373	21	13	often	often	ADV
admet-373	21	14	much	much	ADV
admet-373	21	15	different	different	ADJ
admet-373	21	16	than	than	ADP
admet-373	21	17	designing	design	VERB
admet-373	21	18	discovery	discovery	NOUN
admet-373	21	19	compounds	compound	NOUN
admet-373	21	20	with	with	ADP
admet-373	21	21	simply	simply	ADV
admet-373	21	22	high	high	ADJ
admet-373	21	23	receptor	receptor	NOUN
admet-373	21	24	binding	bind	VERB
admet-373	21	25	or	or	CCONJ
admet-373	21	26	potency	potency	NOUN
admet-373	21	27	.	.	PUNCT
admet-373	22	1	various	various	ADJ
admet-373	22	2	ligand	ligand	ADJ
admet-373	22	3	efficiency	efficiency	NOUN
admet-373	22	4	parameters	parameter	NOUN
admet-373	22	5	have	have	AUX
admet-373	22	6	been	be	AUX
admet-373	22	7	introduced	introduce	VERB
admet-373	22	8	and	and	CCONJ
admet-373	22	9	frequently	frequently	ADV
admet-373	22	10	used	use	VERB
admet-373	22	11	by	by	ADP
admet-373	22	12	medicinal	medicinal	ADJ
admet-373	22	13	chemists	chemist	NOUN
admet-373	22	14	that	that	PRON
admet-373	22	15	relate	relate	VERB
admet-373	22	16	the	the	DET
admet-373	22	17	measured	measured	ADJ
admet-373	22	18	potency	potency	NOUN
admet-373	22	19	to	to	ADP
admet-373	22	20	some	some	DET
admet-373	22	21	calculated	calculate	VERB
admet-373	22	22	properties	property	NOUN
admet-373	22	23	of	of	ADP
admet-373	22	24	the	the	DET
admet-373	22	25	compounds	compound	NOUN
admet-373	22	26	such	such	ADJ
admet-373	22	27	as	as	ADP
admet-373	22	28	,	,	PUNCT
admet-373	22	29	size	size	NOUN
admet-373	22	30	and	and	CCONJ
admet-373	22	31	lipophilicity	lipophilicity	NOUN
admet-373	22	32	as	as	SCONJ
admet-373	22	33	it	it	PRON
admet-373	22	34	has	have	AUX
admet-373	22	35	been	be	AUX
admet-373	22	36	recently	recently	ADV
admet-373	22	37	reviewed	review	VERB
admet-373	22	38	[	[	PUNCT
admet-373	22	39	7	7	NUM
admet-373	22	40	-	-	SYM
admet-373	22	41	8	8	NUM
admet-373	22	42	]	]	PUNCT
admet-373	22	43	.	.	PUNCT
admet-373	23	1	this	this	DET
admet-373	23	2	manuscript	manuscript	NOUN
admet-373	23	3	describes	describe	VERB
admet-373	23	4	how	how	SCONJ
admet-373	23	5	chromatographic	chromatographic	ADJ
admet-373	23	6	analysis	analysis	NOUN
admet-373	23	7	can	can	AUX
admet-373	23	8	efficiently	efficiently	ADV
admet-373	23	9	predict	predict	VERB
admet-373	23	10	or	or	CCONJ
admet-373	23	11	help	help	AUX
admet-373	23	12	select	select	VERB
admet-373	23	13	which	which	DET
admet-373	23	14	compounds	compound	NOUN
admet-373	23	15	have	have	VERB
admet-373	23	16	the	the	DET
admet-373	23	17	greater	great	ADJ
admet-373	23	18	probability	probability	NOUN
admet-373	23	19	of	of	ADP
admet-373	23	20	becoming	become	VERB
admet-373	23	21	lead	lead	ADJ
admet-373	23	22	molecules	molecule	NOUN
admet-373	23	23	by	by	ADP
admet-373	23	24	balancing	balance	VERB
admet-373	23	25	the	the	DET
admet-373	23	26	receptor	receptor	NOUN
admet-373	23	27	binding	bind	VERB
admet-373	23	28	or	or	CCONJ
admet-373	23	29	potency	potency	NOUN
admet-373	23	30	with	with	ADP
admet-373	23	31	optimum	optimum	ADJ
admet-373	23	32	compound	compound	NOUN
admet-373	23	33	distribution	distribution	NOUN
admet-373	23	34	in	in	ADP
admet-373	23	35	vivo	vivo	NOUN
admet-373	23	36	.	.	PUNCT
admet-373	24	1	obviously	obviously	ADV
admet-373	24	2	,	,	PUNCT
admet-373	24	3	achieving	achieve	VERB
admet-373	24	4	good	good	ADJ
admet-373	24	5	oral	oral	ADJ
admet-373	24	6	absorption	absorption	NOUN
admet-373	24	7	alone	alone	ADV
admet-373	24	8	is	be	AUX
admet-373	24	9	not	not	PART
admet-373	24	10	sufficient	sufficient	ADJ
admet-373	24	11	when	when	SCONJ
admet-373	24	12	choosing	choose	VERB
admet-373	24	13	a	a	DET
admet-373	24	14	drug	drug	NOUN
admet-373	24	15	candidate	candidate	NOUN
admet-373	24	16	.	.	PUNCT
admet-373	25	1	overcoming	overcome	VERB
admet-373	25	2	the	the	DET
admet-373	25	3	body	body	NOUN
admet-373	25	4	’s	’s	PART
admet-373	25	5	natural	natural	ADJ
admet-373	25	6	defense	defense	NOUN
admet-373	25	7	mechanisms	mechanism	NOUN
admet-373	25	8	is	be	AUX
admet-373	25	9	also	also	ADV
admet-373	25	10	necessary	necessary	ADJ
admet-373	25	11	to	to	PART
admet-373	25	12	achieve	achieve	VERB
admet-373	25	13	relevant	relevant	ADJ
admet-373	25	14	oral	oral	ADJ
admet-373	25	15	bioavailability	bioavailability	NOUN
admet-373	25	16	as	as	SCONJ
admet-373	25	17	nature	nature	NOUN
admet-373	25	18	has	have	AUX
admet-373	25	19	evolved	evolve	VERB
admet-373	25	20	animal	animal	NOUN
admet-373	25	21	and	and	CCONJ
admet-373	25	22	human	human	ADJ
admet-373	25	23	protection	protection	NOUN
admet-373	25	24	against	against	ADP
admet-373	25	25	potentially	potentially	ADV
admet-373	25	26	harmful	harmful	ADJ
admet-373	25	27	xenobiotics	xenobiotic	NOUN
admet-373	25	28	.	.	PUNCT
admet-373	26	1	some	some	PRON
admet-373	26	2	of	of	ADP
admet-373	26	3	these	these	DET
admet-373	26	4	defense	defense	NOUN
admet-373	26	5	mechanisms	mechanism	NOUN
admet-373	26	6	we	we	PRON
admet-373	26	7	need	need	VERB
admet-373	26	8	to	to	PART
admet-373	26	9	consider	consider	VERB
admet-373	26	10	when	when	SCONJ
admet-373	26	11	developing	develop	VERB
admet-373	26	12	nce	nce	NOUN
admet-373	26	13	’s	’s	PART
admet-373	26	14	are	be	AUX
admet-373	26	15	:	:	PUNCT
admet-373	26	16	(	(	PUNCT
admet-373	26	17	i	i	NOUN
admet-373	26	18	)	)	PUNCT
admet-373	26	19	gut	gut	VERB
admet-373	26	20	metabolism	metabolism	NOUN
admet-373	26	21	,	,	PUNCT
admet-373	26	22	(	(	PUNCT
admet-373	26	23	ii	ii	NOUN
admet-373	26	24	)	)	PUNCT
admet-373	26	25	efflux	efflux	NOUN
admet-373	26	26	processes	process	NOUN
admet-373	26	27	and	and	CCONJ
admet-373	26	28	(	(	PUNCT
admet-373	26	29	iii	iii	NOUN
admet-373	26	30	)	)	PUNCT
admet-373	26	31	first	first	ADV
admet-373	26	32	pass	pass	VERB
admet-373	26	33	metabolism	metabolism	NOUN
admet-373	26	34	.	.	PUNCT
admet-373	27	1	thus	thus	ADV
admet-373	27	2	,	,	PUNCT
admet-373	27	3	ensuring	ensure	VERB
admet-373	27	4	that	that	SCONJ
admet-373	27	5	discovery	discovery	NOUN
admet-373	27	6	molecules	molecule	NOUN
admet-373	27	7	are	be	AUX
admet-373	27	8	not	not	PART
admet-373	27	9	subject	subject	ADJ
admet-373	27	10	to	to	ADP
admet-373	27	11	active	active	ADJ
admet-373	27	12	efflux	efflux	NOUN
admet-373	27	13	and	and	CCONJ
admet-373	27	14	quick	quick	ADJ
admet-373	27	15	elimination	elimination	NOUN
admet-373	27	16	or	or	CCONJ
admet-373	27	17	metabolism	metabolism	NOUN
admet-373	27	18	is	be	AUX
admet-373	27	19	current	current	ADJ
admet-373	27	20	mainstream	mainstream	NOUN
admet-373	27	21	thinking	thinking	NOUN
admet-373	27	22	in	in	ADP
admet-373	27	23	most	most	ADJ
admet-373	27	24	drug	drug	NOUN
admet-373	27	25	discovery	discovery	NOUN
admet-373	27	26	processes	process	NOUN
admet-373	27	27	.	.	PUNCT
admet-373	28	1	the	the	DET
admet-373	28	2	latest	late	ADJ
admet-373	28	3	studies	study	NOUN
admet-373	28	4	show	show	VERB
admet-373	28	5	that	that	SCONJ
admet-373	28	6	the	the	DET
admet-373	28	7	most	most	ADV
admet-373	28	8	significant	significant	ADJ
admet-373	28	9	problem	problem	NOUN
admet-373	28	10	with	with	ADP
admet-373	28	11	the	the	DET
admet-373	28	12	late	late	ADJ
admet-373	28	13	-	-	PUNCT
admet-373	28	14	stage	stage	NOUN
admet-373	28	15	attrition	attrition	NOUN
admet-373	28	16	of	of	ADP
admet-373	28	17	discovery	discovery	NOUN
admet-373	28	18	molecules	molecule	NOUN
admet-373	28	19	is	be	AUX
admet-373	28	20	related	relate	VERB
admet-373	28	21	to	to	ADP
admet-373	28	22	safety	safety	NOUN
admet-373	28	23	and	and	CCONJ
admet-373	28	24	efficacy	efficacy	NOUN
admet-373	28	25	.	.	PUNCT
admet-373	29	1	many	many	ADJ
admet-373	29	2	safety	safety	NOUN
admet-373	29	3	-	-	PUNCT
admet-373	29	4	related	relate	VERB
admet-373	29	5	issues	issue	NOUN
admet-373	29	6	have	have	AUX
admet-373	29	7	been	be	AUX
admet-373	29	8	directly	directly	ADV
admet-373	29	9	attributed	attribute	VERB
admet-373	29	10	to	to	ADP
admet-373	29	11	the	the	DET
admet-373	29	12	lipophilicity	lipophilicity	NOUN
admet-373	29	13	of	of	ADP
admet-373	29	14	compounds	compound	NOUN
admet-373	29	15	[	[	PUNCT
admet-373	29	16	9	9	NUM
admet-373	29	17	-	-	SYM
admet-373	29	18	12	12	NUM
admet-373	29	19	]	]	PUNCT
admet-373	29	20	especially	especially	ADV
admet-373	29	21	when	when	SCONJ
admet-373	29	22	it	it	PRON
admet-373	29	23	is	be	AUX
admet-373	29	24	measured	measure	VERB
admet-373	29	25	using	use	VERB
admet-373	29	26	immobilized	immobilized	ADJ
admet-373	29	27	artificial	artificial	ADJ
admet-373	29	28	membranes	membrane	NOUN
admet-373	29	29	(	(	PUNCT
admet-373	29	30	iams	iam	NOUN
admet-373	29	31	)	)	PUNCT
admet-373	29	32	.	.	PUNCT
admet-373	30	1	high	high	PROPN
admet-373	30	2	iam	iam	PROPN
admet-373	30	3	binding	bind	VERB
admet-373	30	4	is	be	AUX
admet-373	30	5	indicative	indicative	ADJ
admet-373	30	6	of	of	ADP
admet-373	30	7	the	the	DET
admet-373	30	8	compound	compound	NOUN
admet-373	30	9	’s	’s	PART
admet-373	30	10	binding	bind	VERB
admet-373	30	11	to	to	ADP
admet-373	30	12	multiple	multiple	ADJ
admet-373	30	13	targets	target	NOUN
admet-373	30	14	or	or	CCONJ
admet-373	30	15	receptors	receptor	NOUN
admet-373	30	16	,	,	PUNCT
admet-373	30	17	this	this	PRON
admet-373	30	18	is	be	AUX
admet-373	30	19	often	often	ADV
admet-373	30	20	referred	refer	VERB
admet-373	30	21	to	to	ADP
admet-373	30	22	as	as	ADP
admet-373	30	23	compound	compound	NOUN
admet-373	30	24	promiscuity	promiscuity	NOUN
admet-373	30	25	.	.	PUNCT
admet-373	31	1	this	this	PRON
admet-373	31	2	may	may	AUX
admet-373	31	3	cause	cause	VERB
admet-373	31	4	unwanted	unwanted	ADJ
admet-373	31	5	pharmacology	pharmacology	NOUN
admet-373	31	6	or	or	CCONJ
admet-373	31	7	toxicity	toxicity	NOUN
admet-373	31	8	.	.	PUNCT
admet-373	32	1	it	it	PRON
admet-373	32	2	has	have	AUX
admet-373	32	3	previously	previously	ADV
admet-373	32	4	been	be	AUX
admet-373	32	5	shown	show	VERB
admet-373	32	6	that	that	SCONJ
admet-373	32	7	compounds	compound	VERB
admet-373	32	8	that	that	PRON
admet-373	32	9	require	require	VERB
admet-373	32	10	lower	low	ADJ
admet-373	32	11	clinical	clinical	ADJ
admet-373	32	12	dose	dose	NOUN
admet-373	32	13	(	(	PUNCT
admet-373	32	14	ranging	range	VERB
admet-373	32	15	between	between	ADP
admet-373	32	16	1	1	NUM
admet-373	32	17	-	-	SYM
admet-373	32	18	100	100	NUM
admet-373	32	19	mg	mg	NUM
admet-373	32	20	)	)	PUNCT
admet-373	32	21	and	and	CCONJ
admet-373	32	22	therefore	therefore	ADV
admet-373	32	23	lower	low	ADJ
admet-373	32	24	efficacious	efficacious	ADJ
admet-373	32	25	plasma	plasma	NOUN
admet-373	32	26	concentrations	concentration	NOUN
admet-373	32	27	are	be	AUX
admet-373	32	28	less	less	ADV
admet-373	32	29	likely	likely	ADJ
admet-373	32	30	to	to	PART
admet-373	32	31	cause	cause	VERB
admet-373	32	32	toxicity	toxicity	NOUN
admet-373	32	33	[	[	X
admet-373	32	34	9,13	9,13	NUM
admet-373	32	35	]	]	PUNCT
admet-373	32	36	.	.	PUNCT
admet-373	33	1	the	the	DET
admet-373	33	2	root	root	NOUN
admet-373	33	3	cause	cause	NOUN
admet-373	33	4	of	of	ADP
admet-373	33	5	these	these	DET
admet-373	33	6	problems	problem	NOUN
admet-373	33	7	is	be	AUX
admet-373	33	8	partially	partially	ADV
admet-373	33	9	dominated	dominate	VERB
admet-373	33	10	by	by	ADP
admet-373	33	11	the	the	DET
admet-373	33	12	compounds	compound	NOUN
admet-373	33	13	binding	bind	VERB
admet-373	33	14	or	or	CCONJ
admet-373	33	15	partitioning	partition	VERB
admet-373	33	16	into	into	ADP
admet-373	33	17	tissue	tissue	NOUN
admet-373	33	18	which	which	PRON
admet-373	33	19	is	be	AUX
admet-373	33	20	predominantly	predominantly	ADV
admet-373	33	21	comprised	comprise	VERB
admet-373	33	22	of	of	ADP
admet-373	33	23	membrane	membrane	NOUN
admet-373	33	24	phospholipids	phospholipid	NOUN
admet-373	33	25	;	;	PUNCT
admet-373	33	26	when	when	SCONJ
admet-373	33	27	this	this	PRON
admet-373	33	28	happens	happen	VERB
admet-373	33	29	,	,	PUNCT
admet-373	33	30	the	the	DET
admet-373	33	31	drug	drug	NOUN
admet-373	33	32	is	be	AUX
admet-373	33	33	sequestered	sequester	VERB
admet-373	33	34	into	into	ADP
admet-373	33	35	non	non	ADJ
admet-373	33	36	-	-	ADJ
admet-373	33	37	specific	specific	ADJ
admet-373	33	38	phospholipid	phospholipid	NOUN
admet-373	33	39	binding	bind	VERB
admet-373	33	40	sites	site	NOUN
admet-373	33	41	and	and	CCONJ
admet-373	33	42	is	be	AUX
admet-373	33	43	then	then	ADV
admet-373	33	44	less	less	ADV
admet-373	33	45	available	available	ADJ
admet-373	33	46	as	as	ADP
admet-373	33	47	a	a	DET
admet-373	33	48	free	free	ADJ
admet-373	33	49	drug	drug	NOUN
admet-373	33	50	near	near	ADP
admet-373	33	51	the	the	DET
admet-373	33	52	valko	valko	NOUN
admet-373	33	53	,	,	PUNCT
admet-373	33	54	teague	teague	NOUN
admet-373	33	55	and	and	CCONJ
admet-373	33	56	pidgeon	pidgeon	PROPN
admet-373	33	57	admet	admet	PROPN
admet-373	33	58	&	&	CCONJ
admet-373	33	59	dmpk	dmpk	PROPN
admet-373	33	60	5(1	5(1	NUM
admet-373	33	61	)	)	PUNCT
admet-373	33	62	(	(	PUNCT
admet-373	33	63	2017	2017	NUM
admet-373	33	64	)	)	PUNCT
admet-373	33	65	14	14	NUM
admet-373	33	66	-	-	SYM
admet-373	33	67	38	38	NUM
admet-373	33	68	16	16	NUM
admet-373	33	69	target	target	NOUN
admet-373	33	70	of	of	ADP
admet-373	33	71	interest	interest	NOUN
admet-373	33	72	.	.	PUNCT
admet-373	34	1	plasma	plasma	NOUN
admet-373	34	2	proteins	protein	NOUN
admet-373	34	3	can	can	AUX
admet-373	34	4	also	also	ADV
admet-373	34	5	reduce	reduce	VERB
admet-373	34	6	the	the	DET
admet-373	34	7	amount	amount	NOUN
admet-373	34	8	of	of	ADP
admet-373	34	9	free	free	ADJ
admet-373	34	10	drug	drug	NOUN
admet-373	34	11	available	available	ADJ
admet-373	34	12	to	to	PART
admet-373	34	13	interact	interact	VERB
admet-373	34	14	with	with	ADP
admet-373	34	15	enzymes	enzyme	NOUN
admet-373	34	16	/	/	SYM
admet-373	34	17	receptors	receptor	NOUN
admet-373	34	18	(	(	PUNCT
admet-373	34	19	and	and	CCONJ
admet-373	34	20	when	when	SCONJ
admet-373	34	21	this	this	PRON
admet-373	34	22	happens	happen	VERB
admet-373	34	23	an	an	DET
admet-373	34	24	increased	increase	VERB
admet-373	34	25	dose	dose	NOUN
admet-373	34	26	is	be	AUX
admet-373	34	27	essential	essential	ADJ
admet-373	34	28	)	)	PUNCT
admet-373	34	29	.	.	PUNCT
admet-373	35	1	thus	thus	ADV
admet-373	35	2	,	,	PUNCT
admet-373	35	3	the	the	DET
admet-373	35	4	non	non	ADJ
admet-373	35	5	-	-	ADJ
admet-373	35	6	specific	specific	ADJ
admet-373	35	7	binding	bind	VERB
admet-373	35	8	/	/	SYM
admet-373	35	9	partitioning	partitioning	NOUN
admet-373	35	10	of	of	ADP
admet-373	35	11	compounds	compound	NOUN
admet-373	35	12	to	to	ADP
admet-373	35	13	phospholipids	phospholipid	NOUN
admet-373	35	14	and	and	CCONJ
admet-373	35	15	proteins	protein	NOUN
admet-373	35	16	reduce	reduce	VERB
admet-373	35	17	the	the	DET
admet-373	35	18	available	available	ADJ
admet-373	35	19	free	free	ADJ
admet-373	35	20	concentration	concentration	NOUN
admet-373	35	21	at	at	ADP
admet-373	35	22	the	the	DET
admet-373	35	23	site	site	NOUN
admet-373	35	24	of	of	ADP
admet-373	35	25	action	action	NOUN
admet-373	35	26	.	.	PUNCT
admet-373	36	1	thus	thus	ADV
admet-373	36	2	,	,	PUNCT
admet-373	36	3	increased	increase	VERB
admet-373	36	4	doses	dose	NOUN
admet-373	36	5	are	be	AUX
admet-373	36	6	needed	need	VERB
admet-373	36	7	for	for	ADP
admet-373	36	8	activity	activity	NOUN
admet-373	36	9	,	,	PUNCT
admet-373	36	10	but	but	CCONJ
admet-373	36	11	,	,	PUNCT
admet-373	36	12	this	this	PRON
admet-373	36	13	increases	increase	VERB
admet-373	36	14	the	the	DET
admet-373	36	15	possibility	possibility	NOUN
admet-373	36	16	of	of	ADP
admet-373	36	17	undesired	undesired	ADJ
admet-373	36	18	pharmacology	pharmacology	NOUN
admet-373	36	19	or	or	CCONJ
admet-373	36	20	toxicity	toxicity	NOUN
admet-373	36	21	.	.	PUNCT
admet-373	37	1	this	this	DET
admet-373	37	2	paper	paper	NOUN
admet-373	37	3	focuses	focus	VERB
admet-373	37	4	on	on	ADP
admet-373	37	5	the	the	DET
admet-373	37	6	role	role	NOUN
admet-373	37	7	of	of	ADP
admet-373	37	8	distribution	distribution	NOUN
admet-373	37	9	in	in	ADP
admet-373	37	10	the	the	DET
admet-373	37	11	absorption	absorption	NOUN
admet-373	37	12	,	,	PUNCT
admet-373	37	13	distribution	distribution	NOUN
admet-373	37	14	,	,	PUNCT
admet-373	37	15	metabolism	metabolism	NOUN
admet-373	37	16	and	and	CCONJ
admet-373	37	17	elimination	elimination	NOUN
admet-373	37	18	(	(	PUNCT
admet-373	37	19	adme	adme	NOUN
admet-373	37	20	)	)	PUNCT
admet-373	37	21	process	process	NOUN
admet-373	37	22	,	,	PUNCT
admet-373	37	23	without	without	ADP
admet-373	37	24	neglecting	neglect	VERB
admet-373	37	25	the	the	DET
admet-373	37	26	absorption	absorption	NOUN
admet-373	37	27	and	and	CCONJ
admet-373	37	28	clearance	clearance	NOUN
admet-373	37	29	that	that	PRON
admet-373	37	30	regulate	regulate	VERB
admet-373	37	31	the	the	DET
admet-373	37	32	magnitude	magnitude	NOUN
admet-373	37	33	and	and	CCONJ
admet-373	37	34	the	the	DET
admet-373	37	35	frequency	frequency	NOUN
admet-373	37	36	of	of	ADP
admet-373	37	37	dosing	dosing	NOUN
admet-373	37	38	.	.	PUNCT
admet-373	38	1	we	we	PRON
admet-373	38	2	propose	propose	VERB
admet-373	38	3	to	to	PART
admet-373	38	4	design	design	VERB
admet-373	38	5	and	and	CCONJ
admet-373	38	6	triage	triage	NOUN
admet-373	38	7	nces	nce	NOUN
admet-373	38	8	based	base	VERB
admet-373	38	9	on	on	ADP
admet-373	38	10	their	their	PRON
admet-373	38	11	in	in	X
admet-373	38	12	vitro	vitro	X
admet-373	38	13	distribution	distribution	NOUN
admet-373	38	14	behavior	behavior	NOUN
admet-373	38	15	that	that	PRON
admet-373	38	16	determines	determine	VERB
admet-373	38	17	the	the	DET
admet-373	38	18	amount	amount	NOUN
admet-373	38	19	/	/	SYM
admet-373	38	20	concentration	concentration	NOUN
admet-373	38	21	of	of	ADP
admet-373	38	22	compounds	compound	NOUN
admet-373	38	23	in	in	ADP
admet-373	38	24	various	various	ADJ
admet-373	38	25	tissue	tissue	NOUN
admet-373	38	26	compartments	compartment	NOUN
admet-373	38	27	,	,	PUNCT
admet-373	38	28	and	and	CCONJ
admet-373	38	29	the	the	DET
admet-373	38	30	free	free	ADJ
admet-373	38	31	unbound	unbound	NOUN
admet-373	38	32	compartments	compartment	NOUN
admet-373	38	33	that	that	PRON
admet-373	38	34	are	be	AUX
admet-373	38	35	responsible	responsible	ADJ
admet-373	38	36	for	for	ADP
admet-373	38	37	safety	safety	NOUN
admet-373	38	38	issues	issue	NOUN
admet-373	38	39	and	and	CCONJ
admet-373	38	40	efficacy	efficacy	NOUN
admet-373	38	41	,	,	PUNCT
admet-373	38	42	respectively	respectively	ADV
admet-373	38	43	.	.	PUNCT
admet-373	39	1	this	this	PRON
admet-373	39	2	can	can	AUX
admet-373	39	3	be	be	AUX
admet-373	39	4	achieved	achieve	VERB
admet-373	39	5	by	by	ADP
admet-373	39	6	using	use	VERB
admet-373	39	7	some	some	PRON
admet-373	39	8	of	of	ADP
admet-373	39	9	the	the	DET
admet-373	39	10	major	major	ADJ
admet-373	39	11	protein	protein	NOUN
admet-373	39	12	components	component	NOUN
admet-373	39	13	which	which	PRON
admet-373	39	14	make	make	VERB
admet-373	39	15	up	up	ADP
admet-373	39	16	tissues	tissue	NOUN
admet-373	39	17	in	in	ADP
admet-373	39	18	the	the	DET
admet-373	39	19	body	body	NOUN
admet-373	39	20	as	as	ADP
admet-373	39	21	chromatographic	chromatographic	ADJ
admet-373	39	22	stationary	stationary	ADJ
admet-373	39	23	phases	phase	NOUN
admet-373	39	24	,	,	PUNCT
admet-373	39	25	this	this	PRON
admet-373	39	26	is	be	AUX
admet-373	39	27	called	call	VERB
admet-373	39	28	biomimetic	biomimetic	ADJ
admet-373	39	29	chromatography	chromatography	NOUN
admet-373	39	30	and	and	CCONJ
admet-373	39	31	has	have	AUX
admet-373	39	32	been	be	AUX
admet-373	39	33	recently	recently	ADV
admet-373	39	34	reviewed	review	VERB
admet-373	39	35	[	[	PUNCT
admet-373	39	36	14	14	NUM
admet-373	39	37	]	]	PUNCT
admet-373	39	38	.	.	PUNCT
admet-373	40	1	we	we	PRON
admet-373	40	2	also	also	ADV
admet-373	40	3	propose	propose	VERB
admet-373	40	4	that	that	SCONJ
admet-373	40	5	the	the	DET
admet-373	40	6	unbound	unbound	NOUN
admet-373	40	7	volume	volume	NOUN
admet-373	40	8	of	of	ADP
admet-373	40	9	distribution	distribution	NOUN
admet-373	40	10	of	of	ADP
admet-373	40	11	compounds	compound	NOUN
admet-373	40	12	is	be	AUX
admet-373	40	13	an	an	DET
admet-373	40	14	important	important	ADJ
admet-373	40	15	parameter	parameter	NOUN
admet-373	40	16	to	to	PART
admet-373	40	17	consider	consider	VERB
admet-373	40	18	,	,	PUNCT
admet-373	40	19	as	as	SCONJ
admet-373	40	20	this	this	PRON
admet-373	40	21	in	in	ADP
admet-373	40	22	vivo	vivo	NOUN
admet-373	40	23	parameter	parameter	NOUN
admet-373	40	24	describes	describe	VERB
admet-373	40	25	the	the	DET
admet-373	40	26	proportion	proportion	NOUN
admet-373	40	27	of	of	ADP
admet-373	40	28	the	the	DET
admet-373	40	29	dose	dose	NOUN
admet-373	40	30	relative	relative	NOUN
admet-373	40	31	to	to	ADP
admet-373	40	32	the	the	DET
admet-373	40	33	free	free	ADJ
admet-373	40	34	plasma	plasma	NOUN
admet-373	40	35	concentration	concentration	NOUN
admet-373	40	36	of	of	ADP
admet-373	40	37	compounds	compound	NOUN
admet-373	40	38	in	in	ADP
admet-373	40	39	steady	steady	ADJ
admet-373	40	40	state	state	NOUN
admet-373	40	41	[	[	X
admet-373	40	42	15	15	NUM
admet-373	40	43	]	]	PUNCT
admet-373	40	44	.	.	PUNCT
admet-373	41	1	based	base	VERB
admet-373	41	2	on	on	ADP
admet-373	41	3	the	the	DET
admet-373	41	4	free	free	ADJ
admet-373	41	5	drug	drug	NOUN
admet-373	41	6	hypothesis	hypothesis	NOUN
admet-373	41	7	,	,	PUNCT
admet-373	41	8	[	[	X
admet-373	41	9	16	16	NUM
admet-373	41	10	]	]	PUNCT
admet-373	41	11	the	the	DET
admet-373	41	12	free	free	ADJ
admet-373	41	13	plasma	plasma	NOUN
admet-373	41	14	concentration	concentration	NOUN
admet-373	41	15	is	be	AUX
admet-373	41	16	the	the	DET
admet-373	41	17	same	same	ADJ
admet-373	41	18	as	as	ADP
admet-373	41	19	the	the	DET
admet-373	41	20	free	free	ADJ
admet-373	41	21	tissue	tissue	NOUN
admet-373	41	22	concentration	concentration	NOUN
admet-373	41	23	,	,	PUNCT
admet-373	41	24	when	when	SCONJ
admet-373	41	25	no	no	DET
admet-373	41	26	permeability	permeability	NOUN
admet-373	41	27	barrier	barrier	NOUN
admet-373	41	28	or	or	CCONJ
admet-373	41	29	active	active	ADJ
admet-373	41	30	transport	transport	NOUN
admet-373	41	31	distorts	distort	VERB
admet-373	41	32	the	the	DET
admet-373	41	33	thermodynamic	thermodynamic	ADJ
admet-373	41	34	equilibrium	equilibrium	NOUN
admet-373	41	35	,	,	PUNCT
admet-373	41	36	between	between	ADP
admet-373	41	37	plasma	plasma	NOUN
admet-373	41	38	and	and	CCONJ
admet-373	41	39	tissues	tissue	NOUN
admet-373	41	40	which	which	PRON
admet-373	41	41	contain	contain	VERB
admet-373	41	42	the	the	DET
admet-373	41	43	therapeutic	therapeutic	ADJ
admet-373	41	44	targets	target	NOUN
admet-373	41	45	.	.	PUNCT
admet-373	42	1	though	though	SCONJ
admet-373	42	2	active	active	ADJ
admet-373	42	3	transporters	transporter	NOUN
admet-373	42	4	may	may	AUX
admet-373	42	5	have	have	VERB
admet-373	42	6	a	a	DET
admet-373	42	7	significant	significant	ADJ
admet-373	42	8	effect	effect	NOUN
admet-373	42	9	on	on	ADP
admet-373	42	10	the	the	DET
admet-373	42	11	free	free	ADJ
admet-373	42	12	concentration	concentration	NOUN
admet-373	42	13	of	of	ADP
admet-373	42	14	a	a	DET
admet-373	42	15	drug	drug	NOUN
admet-373	42	16	on	on	ADP
admet-373	42	17	the	the	DET
admet-373	42	18	two	two	NUM
admet-373	42	19	sides	side	NOUN
admet-373	42	20	of	of	ADP
admet-373	42	21	the	the	DET
admet-373	42	22	membrane	membrane	NOUN
admet-373	42	23	[	[	X
admet-373	42	24	17	17	NUM
admet-373	42	25	]	]	PUNCT
admet-373	42	26	,	,	PUNCT
admet-373	42	27	the	the	DET
admet-373	42	28	concentration	concentration	NOUN
admet-373	42	29	difference	difference	NOUN
admet-373	42	30	can	can	AUX
admet-373	42	31	be	be	AUX
admet-373	42	32	explained	explain	VERB
admet-373	42	33	by	by	ADP
admet-373	42	34	strong	strong	ADJ
admet-373	42	35	binding	binding	NOUN
admet-373	42	36	of	of	ADP
admet-373	42	37	the	the	DET
admet-373	42	38	drug	drug	NOUN
admet-373	42	39	to	to	ADP
admet-373	42	40	intracellular	intracellular	ADJ
admet-373	42	41	components	component	NOUN
admet-373	42	42	.	.	PUNCT
admet-373	43	1	the	the	DET
admet-373	43	2	free	free	ADJ
admet-373	43	3	concentration	concentration	NOUN
admet-373	43	4	difference	difference	NOUN
admet-373	43	5	is	be	AUX
admet-373	43	6	usually	usually	ADV
admet-373	43	7	not	not	PART
admet-373	43	8	more	more	ADJ
admet-373	43	9	than	than	ADP
admet-373	43	10	an	an	DET
admet-373	43	11	order	order	NOUN
admet-373	43	12	of	of	ADP
admet-373	43	13	magnitude	magnitude	NOUN
admet-373	43	14	on	on	ADP
admet-373	43	15	the	the	DET
admet-373	43	16	two	two	NUM
admet-373	43	17	sides	side	NOUN
admet-373	43	18	of	of	ADP
admet-373	43	19	the	the	DET
admet-373	43	20	membrane	membrane	NOUN
admet-373	43	21	due	due	ADP
admet-373	43	22	to	to	ADP
admet-373	43	23	active	active	ADJ
admet-373	43	24	transporters	transporter	NOUN
admet-373	43	25	that	that	PRON
admet-373	43	26	require	require	VERB
admet-373	43	27	constant	constant	ADJ
admet-373	43	28	energy	energy	NOUN
admet-373	43	29	supply	supply	NOUN
admet-373	43	30	to	to	PART
admet-373	43	31	keep	keep	VERB
admet-373	43	32	the	the	DET
admet-373	43	33	concentration	concentration	NOUN
admet-373	43	34	difference	difference	NOUN
admet-373	43	35	.	.	PUNCT
admet-373	44	1	distorting	distort	VERB
admet-373	44	2	the	the	DET
admet-373	44	3	thermodynamic	thermodynamic	ADJ
admet-373	44	4	equilibrium	equilibrium	NOUN
admet-373	44	5	by	by	ADP
admet-373	44	6	two	two	NUM
admet-373	44	7	to	to	PART
admet-373	44	8	three	three	NUM
admet-373	44	9	orders	order	NOUN
admet-373	44	10	of	of	ADP
admet-373	44	11	magnitude	magnitude	NOUN
admet-373	44	12	would	would	AUX
admet-373	44	13	require	require	VERB
admet-373	44	14	constant	constant	ADJ
admet-373	44	15	energy	energy	NOUN
admet-373	44	16	supply	supply	NOUN
admet-373	44	17	(	(	PUNCT
admet-373	44	18	atp	atp	PROPN
admet-373	44	19	)	)	PUNCT
admet-373	44	20	,	,	PUNCT
admet-373	44	21	and	and	CCONJ
admet-373	44	22	the	the	DET
admet-373	44	23	active	active	ADJ
admet-373	44	24	transporters	transporter	NOUN
admet-373	44	25	may	may	AUX
admet-373	44	26	become	become	VERB
admet-373	44	27	easily	easily	ADV
admet-373	44	28	saturated	saturate	VERB
admet-373	44	29	.	.	PUNCT
admet-373	45	1	the	the	DET
admet-373	45	2	unbound	unbound	NOUN
admet-373	45	3	volume	volume	NOUN
admet-373	45	4	of	of	ADP
admet-373	45	5	distribution	distribution	NOUN
admet-373	45	6	can	can	AUX
admet-373	45	7	be	be	AUX
admet-373	45	8	considered	consider	VERB
admet-373	45	9	as	as	ADP
admet-373	45	10	a	a	DET
admet-373	45	11	proportional	proportional	ADJ
admet-373	45	12	parameter	parameter	NOUN
admet-373	45	13	to	to	ADP
admet-373	45	14	the	the	DET
admet-373	45	15	drug	drug	NOUN
admet-373	45	16	partition	partition	NOUN
admet-373	45	17	coefficient	coefficient	NOUN
admet-373	45	18	between	between	ADP
admet-373	45	19	the	the	DET
admet-373	45	20	free	free	ADJ
admet-373	45	21	and	and	CCONJ
admet-373	45	22	bound	bound	ADJ
admet-373	45	23	compartments	compartment	NOUN
admet-373	45	24	.	.	PUNCT
admet-373	46	1	in	in	ADP
admet-373	46	2	this	this	DET
admet-373	46	3	respect	respect	NOUN
admet-373	46	4	,	,	PUNCT
admet-373	46	5	it	it	PRON
admet-373	46	6	is	be	AUX
admet-373	46	7	very	very	ADV
admet-373	46	8	similar	similar	ADJ
admet-373	46	9	to	to	ADP
admet-373	46	10	the	the	DET
admet-373	46	11	recently	recently	ADV
admet-373	46	12	introduced	introduce	VERB
admet-373	46	13	drug	drug	NOUN
admet-373	46	14	efficiency	efficiency	NOUN
admet-373	46	15	parameter	parameter	NOUN
admet-373	46	16	that	that	PRON
admet-373	46	17	relates	relate	VERB
admet-373	46	18	the	the	DET
admet-373	46	19	free	free	ADJ
admet-373	46	20	bio	bio	NOUN
admet-373	46	21	-	-	ADJ
admet-373	46	22	phase	phase	NOUN
admet-373	46	23	concentration	concentration	NOUN
admet-373	46	24	to	to	ADP
admet-373	46	25	the	the	DET
admet-373	46	26	dose	dose	NOUN
admet-373	46	27	.	.	PUNCT
admet-373	47	1	the	the	DET
admet-373	47	2	drug	drug	NOUN
admet-373	47	3	efficiency	efficiency	NOUN
admet-373	47	4	concept	concept	NOUN
admet-373	47	5	that	that	PRON
admet-373	47	6	was	be	AUX
admet-373	47	7	introduced	introduce	VERB
admet-373	47	8	by	by	ADP
admet-373	47	9	braggio	braggio	NOUN
admet-373	47	10	[	[	X
admet-373	47	11	18	18	NUM
admet-373	47	12	]	]	PUNCT
admet-373	47	13	highlights	highlight	VERB
admet-373	47	14	the	the	DET
admet-373	47	15	importance	importance	NOUN
admet-373	47	16	of	of	ADP
admet-373	47	17	the	the	DET
admet-373	47	18	free	free	ADJ
admet-373	47	19	concentration	concentration	NOUN
admet-373	47	20	of	of	ADP
admet-373	47	21	the	the	DET
admet-373	47	22	drug	drug	NOUN
admet-373	47	23	in	in	ADP
admet-373	47	24	the	the	DET
admet-373	47	25	biophase	biophase	NOUN
admet-373	47	26	near	near	ADP
admet-373	47	27	the	the	DET
admet-373	47	28	target	target	NOUN
admet-373	47	29	relative	relative	ADJ
admet-373	47	30	to	to	ADP
admet-373	47	31	the	the	DET
admet-373	47	32	dose	dose	NOUN
admet-373	47	33	to	to	PART
admet-373	47	34	achieve	achieve	VERB
admet-373	47	35	efficient	efficient	ADJ
admet-373	47	36	pk	pk	PROPN
admet-373	47	37	/	/	SYM
admet-373	47	38	pd	pd	NOUN
admet-373	47	39	of	of	ADP
admet-373	47	40	a	a	DET
admet-373	47	41	drug	drug	NOUN
admet-373	47	42	molecule	molecule	NOUN
admet-373	47	43	.	.	PUNCT
admet-373	48	1	the	the	DET
admet-373	48	2	drug	drug	NOUN
admet-373	48	3	efficiency	efficiency	NOUN
admet-373	48	4	index	index	NOUN
admet-373	48	5	,	,	PUNCT
admet-373	48	6	dei	dei	NOUN
admet-373	48	7	highlights	highlight	NOUN
admet-373	48	8	the	the	DET
admet-373	48	9	importance	importance	NOUN
admet-373	48	10	of	of	ADP
admet-373	48	11	balancing	balance	VERB
admet-373	48	12	the	the	DET
admet-373	48	13	potency	potency	NOUN
admet-373	48	14	and	and	CCONJ
admet-373	48	15	drug	drug	NOUN
admet-373	48	16	efficiency	efficiency	NOUN
admet-373	48	17	of	of	ADP
admet-373	48	18	the	the	DET
admet-373	48	19	molecules	molecule	NOUN
admet-373	48	20	and	and	CCONJ
admet-373	48	21	is	be	AUX
admet-373	48	22	proposed	propose	VERB
admet-373	48	23	as	as	ADP
admet-373	48	24	an	an	DET
admet-373	48	25	alternative	alternative	ADJ
admet-373	48	26	parameter	parameter	NOUN
admet-373	48	27	to	to	PART
admet-373	48	28	simply	simply	ADV
admet-373	48	29	focusing	focus	VERB
admet-373	48	30	on	on	ADP
admet-373	48	31	potency	potency	NOUN
admet-373	48	32	,	,	PUNCT
admet-373	48	33	as	as	SCONJ
admet-373	48	34	other	other	ADJ
admet-373	48	35	ligand	ligand	NOUN
admet-373	48	36	efficiency	efficiency	NOUN
admet-373	48	37	parameters	parameter	NOUN
admet-373	48	38	tend	tend	VERB
admet-373	48	39	to	to	PART
admet-373	48	40	be	be	AUX
admet-373	48	41	biased	bias	VERB
admet-373	48	42	towards	towards	ADP
admet-373	48	43	[	[	X
admet-373	48	44	19	19	NUM
admet-373	48	45	]	]	PUNCT
admet-373	48	46	.	.	PUNCT
admet-373	49	1	the	the	DET
admet-373	49	2	dei	dei	NOUN
admet-373	49	3	concept	concept	NOUN
admet-373	49	4	also	also	ADV
admet-373	49	5	helps	help	VERB
admet-373	49	6	designing	design	VERB
admet-373	49	7	drug	drug	NOUN
admet-373	49	8	molecules	molecule	NOUN
admet-373	49	9	with	with	ADP
admet-373	49	10	a	a	DET
admet-373	49	11	low	low	ADJ
admet-373	49	12	therapeutic	therapeutic	ADJ
admet-373	49	13	dose	dose	NOUN
admet-373	49	14	that	that	SCONJ
admet-373	49	15	in	in	ADP
admet-373	49	16	turn	turn	NOUN
admet-373	49	17	reduce	reduce	VERB
admet-373	49	18	general	general	ADJ
admet-373	49	19	toxicity	toxicity	NOUN
admet-373	49	20	.	.	PUNCT
admet-373	50	1	table	table	NOUN
admet-373	50	2	1	1	NUM
admet-373	50	3	shows	show	VERB
admet-373	50	4	the	the	DET
admet-373	50	5	abbreviations	abbreviation	NOUN
admet-373	50	6	and	and	CCONJ
admet-373	50	7	their	their	PRON
admet-373	50	8	meaning	meaning	NOUN
admet-373	50	9	of	of	ADP
admet-373	50	10	the	the	DET
admet-373	50	11	properties	property	NOUN
admet-373	50	12	that	that	PRON
admet-373	50	13	are	be	AUX
admet-373	50	14	investigated	investigate	VERB
admet-373	50	15	in	in	ADP
admet-373	50	16	this	this	DET
admet-373	50	17	paper	paper	NOUN
admet-373	50	18	,	,	PUNCT
admet-373	50	19	while	while	SCONJ
admet-373	50	20	table	table	NOUN
admet-373	50	21	2	2	NUM
admet-373	50	22	shows	show	VERB
admet-373	50	23	the	the	DET
admet-373	50	24	equations	equation	NOUN
admet-373	50	25	how	how	SCONJ
admet-373	50	26	they	they	PRON
admet-373	50	27	are	be	AUX
admet-373	50	28	calculated	calculate	VERB
admet-373	50	29	and	and	CCONJ
admet-373	50	30	how	how	SCONJ
admet-373	50	31	they	they	PRON
admet-373	50	32	are	be	AUX
admet-373	50	33	related	relate	VERB
admet-373	50	34	to	to	ADP
admet-373	50	35	each	each	DET
admet-373	50	36	other	other	ADJ
admet-373	50	37	.	.	PUNCT
admet-373	51	1	the	the	DET
admet-373	51	2	drug	drug	NOUN
admet-373	51	3	distribution	distribution	NOUN
admet-373	51	4	properties	property	NOUN
admet-373	51	5	are	be	AUX
admet-373	51	6	most	most	ADV
admet-373	51	7	often	often	ADV
admet-373	51	8	characterised	characterise	VERB
admet-373	51	9	by	by	ADP
admet-373	51	10	lipophilicity	lipophilicity	PROPN
admet-373	51	11	.	.	PUNCT
admet-373	52	1	lipophilicity	lipophilicity	NOUN
admet-373	52	2	has	have	AUX
admet-373	52	3	been	be	AUX
admet-373	52	4	recognised	recognise	VERB
admet-373	52	5	for	for	ADP
admet-373	52	6	a	a	DET
admet-373	52	7	long	long	ADJ
admet-373	52	8	time	time	NOUN
admet-373	52	9	as	as	ADP
admet-373	52	10	the	the	DET
admet-373	52	11	principal	principal	ADJ
admet-373	52	12	parameter	parameter	NOUN
admet-373	52	13	that	that	PRON
admet-373	52	14	influences	influence	VERB
admet-373	52	15	solubility	solubility	NOUN
admet-373	52	16	[	[	X
admet-373	52	17	20,21	20,21	NUM
admet-373	52	18	]	]	PUNCT
admet-373	52	19	,	,	PUNCT
admet-373	52	20	permeability	permeability	NOUN
admet-373	53	1	[	[	X
admet-373	53	2	22	22	NUM
admet-373	53	3	]	]	PUNCT
admet-373	53	4	,	,	PUNCT
admet-373	53	5	tissue	tissue	NOUN
admet-373	53	6	binding	bind	VERB
admet-373	53	7	,	,	PUNCT
admet-373	53	8	protein	protein	NOUN
admet-373	53	9	binding	bind	VERB
admet-373	53	10	[	[	X
admet-373	53	11	23,24	23,24	NUM
admet-373	53	12	]	]	PUNCT
admet-373	53	13	,	,	PUNCT
admet-373	53	14	toxicity	toxicity	NOUN
admet-373	53	15	[	[	X
admet-373	53	16	10	10	NUM
admet-373	53	17	]	]	PUNCT
admet-373	53	18	,	,	PUNCT
admet-373	53	19	promiscuity	promiscuity	NOUN
admet-373	54	1	[	[	X
admet-373	54	2	1	1	NUM
admet-373	54	3	]	]	PUNCT
admet-373	54	4	,	,	PUNCT
admet-373	54	5	clearance	clearance	NOUN
admet-373	54	6	[	[	X
admet-373	54	7	25	25	NUM
admet-373	54	8	]	]	PUNCT
admet-373	54	9	etc	etc	X
admet-373	54	10	.	.	X
admet-373	54	11	several	several	ADJ
admet-373	54	12	ligand	ligand	ADJ
admet-373	54	13	efficiency	efficiency	NOUN
admet-373	54	14	parameters	parameter	NOUN
admet-373	54	15	contain	contain	VERB
admet-373	54	16	the	the	DET
admet-373	54	17	lipophilicity	lipophilicity	NOUN
admet-373	54	18	and	and	CCONJ
admet-373	54	19	propose	propose	VERB
admet-373	54	20	to	to	PART
admet-373	54	21	consider	consider	VERB
admet-373	54	22	the	the	DET
admet-373	54	23	potency	potency	NOUN
admet-373	54	24	relative	relative	ADJ
admet-373	54	25	to	to	ADP
admet-373	54	26	the	the	DET
admet-373	54	27	lipophilicity	lipophilicity	NOUN
admet-373	54	28	of	of	ADP
admet-373	54	29	the	the	DET
admet-373	54	30	compounds	compound	NOUN
admet-373	54	31	,	,	PUNCT
admet-373	54	32	such	such	ADJ
admet-373	54	33	as	as	ADP
admet-373	54	34	ligand	ligand	NOUN
admet-373	54	35	lipophilicity	lipophilicity	NOUN
admet-373	54	36	efficiency	efficiency	NOUN
admet-373	54	37	,	,	PUNCT
admet-373	54	38	lle	lle	PROPN
admet-373	55	1	[	[	X
admet-373	55	2	7,26	7,26	NOUN
admet-373	55	3	]	]	PUNCT
admet-373	55	4	.	.	PUNCT
admet-373	56	1	recently	recently	ADV
admet-373	56	2	,	,	PUNCT
admet-373	56	3	the	the	DET
admet-373	56	4	chromatographic	chromatographic	ADJ
admet-373	56	5	lipophilicity	lipophilicity	NOUN
admet-373	56	6	has	have	AUX
admet-373	56	7	been	be	AUX
admet-373	56	8	combined	combine	VERB
admet-373	56	9	with	with	ADP
admet-373	56	10	the	the	DET
admet-373	56	11	number	number	NOUN
admet-373	56	12	of	of	ADP
admet-373	56	13	aromatic	aromatic	ADJ
admet-373	56	14	rings	ring	NOUN
admet-373	56	15	in	in	ADP
admet-373	56	16	the	the	DET
admet-373	56	17	molecules	molecule	NOUN
admet-373	56	18	to	to	PART
admet-373	56	19	derive	derive	VERB
admet-373	56	20	the	the	DET
admet-373	56	21	property	property	NOUN
admet-373	56	22	forecast	forecast	NOUN
admet-373	56	23	index	index	NOUN
admet-373	56	24	(	(	PUNCT
admet-373	56	25	pfi	pfi	NOUN
admet-373	56	26	)	)	PUNCT
admet-373	57	1	[	[	X
admet-373	57	2	27	27	NUM
admet-373	57	3	]	]	PUNCT
admet-373	57	4	.	.	PUNCT
admet-373	58	1	it	it	PRON
admet-373	58	2	has	have	AUX
admet-373	58	3	been	be	AUX
admet-373	58	4	suggested	suggest	VERB
admet-373	58	5	that	that	SCONJ
admet-373	58	6	having	have	VERB
admet-373	58	7	a	a	DET
admet-373	58	8	pfi	pfi	NOUN
admet-373	58	9	value	value	NOUN
admet-373	58	10	less	less	ADJ
admet-373	58	11	than	than	ADP
admet-373	58	12	6	6	NUM
admet-373	58	13	for	for	ADP
admet-373	58	14	admet	admet	PROPN
admet-373	58	15	&	&	CCONJ
admet-373	58	16	dmpk	dmpk	PROPN
admet-373	58	17	5(1	5(1	NUM
admet-373	58	18	)	)	PUNCT
admet-373	58	19	(	(	PUNCT
admet-373	58	20	2017	2017	NUM
admet-373	58	21	)	)	PUNCT
admet-373	58	22	14	14	NUM
admet-373	58	23	-	-	SYM
admet-373	58	24	38	38	NUM
admet-373	58	25	in	in	ADP
admet-373	58	26	vitro	vitro	X
admet-373	58	27	membrane	membrane	NOUN
admet-373	58	28	and	and	CCONJ
admet-373	58	29	protein	protein	NOUN
admet-373	58	30	binding	bind	VERB
admet-373	58	31	doi	doi	NOUN
admet-373	58	32	:	:	PUNCT
admet-373	58	33	10.5599	10.5599	NUM
admet-373	58	34	/	/	SYM
admet-373	58	35	admet.5.1.373	admet.5.1.373	ADP
admet-373	58	36	17	17	NUM
admet-373	58	37	drug	drug	NOUN
admet-373	58	38	discovery	discovery	NOUN
admet-373	58	39	compounds	compound	NOUN
admet-373	58	40	increases	increase	VERB
admet-373	58	41	the	the	DET
admet-373	58	42	probability	probability	NOUN
admet-373	58	43	of	of	ADP
admet-373	58	44	improving	improve	VERB
admet-373	58	45	drug	drug	NOUN
admet-373	58	46	attrition	attrition	NOUN
admet-373	58	47	rates	rate	NOUN
admet-373	58	48	.	.	PUNCT
admet-373	59	1	table	table	NOUN
admet-373	59	2	1	1	NUM
admet-373	59	3	.	.	PUNCT
admet-373	60	1	variables	variable	NOUN
admet-373	60	2	,	,	PUNCT
admet-373	60	3	abbreviations	abbreviation	NOUN
admet-373	60	4	used	use	VERB
admet-373	60	5	throughout	throughout	ADP
admet-373	60	6	the	the	DET
admet-373	60	7	text	text	NOUN
admet-373	60	8	iam	iam	PROPN
admet-373	60	9	immobilized	immobilize	VERB
admet-373	60	10	artificial	artificial	ADJ
admet-373	60	11	membrane	membrane	NOUN
admet-373	60	12	(	(	PUNCT
admet-373	60	13	hplc	hplc	NOUN
admet-373	60	14	stationary	stationary	ADJ
admet-373	60	15	phase	phase	NOUN
admet-373	60	16	_	_	PUNCT
admet-373	61	1	hsa	hsa	VERB
admet-373	61	2	human	human	ADJ
admet-373	61	3	serum	serum	NOUN
admet-373	61	4	albumin	albumin	PROPN
admet-373	61	5	agp	agp	PROPN
admet-373	61	6	alpha-1	alpha-1	NOUN
admet-373	61	7	-	-	PUNCT
admet-373	61	8	acid	acid	NOUN
admet-373	61	9	-	-	PUNCT
admet-373	61	10	glycoprotein	glycoprotein	NOUN
admet-373	61	11	ppb	ppb	NOUN
admet-373	61	12	total	total	ADJ
admet-373	61	13	plasma	plasma	NOUN
admet-373	61	14	protein	protein	NOUN
admet-373	61	15	binding	bind	VERB
admet-373	61	16	mb	mb	ADP
admet-373	61	17	membrane	membrane	NOUN
admet-373	61	18	binding	bind	VERB
admet-373	61	19	(	(	PUNCT
admet-373	61	20	measured	measure	VERB
admet-373	61	21	by	by	ADP
admet-373	61	22	iam	iam	PROPN
admet-373	61	23	)	)	PUNCT
admet-373	61	24	mb	mb	PROPN
admet-373	61	25	/	/	SYM
admet-373	61	26	pb	pb	X
admet-373	61	27	membrane	membrane	NOUN
admet-373	61	28	binding	bind	VERB
admet-373	61	29	and	and	CCONJ
admet-373	61	30	protein	protein	NOUN
admet-373	61	31	binding	bind	VERB
admet-373	61	32	vdss	vdss	ADV
admet-373	61	33	steady	steady	ADJ
admet-373	61	34	state	state	NOUN
admet-373	61	35	volume	volume	NOUN
admet-373	61	36	of	of	ADP
admet-373	61	37	distribution	distribution	NOUN
admet-373	61	38	(	(	PUNCT
admet-373	61	39	dose	dose	NOUN
admet-373	61	40	/	/	SYM
admet-373	61	41	plasma	plasma	NOUN
admet-373	61	42	concentration	concentration	NOUN
admet-373	61	43	)	)	PUNCT
admet-373	62	1	vdu	vdu	PROPN
admet-373	62	2	steady	steady	ADJ
admet-373	62	3	state	state	NOUN
admet-373	62	4	unbound	unbound	NOUN
admet-373	62	5	volume	volume	NOUN
admet-373	62	6	of	of	ADP
admet-373	62	7	distribution	distribution	NOUN
admet-373	62	8	(	(	PUNCT
admet-373	62	9	dose	dose	NOUN
admet-373	62	10	/	/	SYM
admet-373	62	11	free	free	ADJ
admet-373	62	12	plasma	plasma	NOUN
admet-373	62	13	concentration=	concentration=	NUM
admet-373	62	14	vd	vd	NOUN
admet-373	62	15	/	/	SYM
admet-373	62	16	fu	fu	ADJ
admet-373	62	17	)	)	PUNCT
admet-373	62	18	fu	fu	NOUN
admet-373	62	19	unbound	unbound	NOUN
admet-373	62	20	fraction	fraction	NOUN
admet-373	62	21	in	in	ADP
admet-373	62	22	plasma	plasma	NOUN
admet-373	62	23	de	de	X
admet-373	62	24	drug	drug	NOUN
admet-373	62	25	efficiency	efficiency	NOUN
admet-373	62	26	(	(	PUNCT
admet-373	62	27	100	100	NUM
admet-373	62	28	*	*	PUNCT
admet-373	62	29	free	free	ADJ
admet-373	62	30	biophase	biophase	NOUN
admet-373	62	31	conc	conc	VERB
admet-373	62	32	/	/	SYM
admet-373	62	33	dose	dose	NOUN
admet-373	62	34	)	)	PUNCT
admet-373	62	35	demax	demax	NOUN
admet-373	62	36	drug	drug	NOUN
admet-373	62	37	efficiency	efficiency	NOUN
admet-373	62	38	measured	measure	VERB
admet-373	62	39	by	by	ADP
admet-373	62	40	mb	mb	PROPN
admet-373	62	41	/	/	SYM
admet-373	62	42	pb	pb	NOUN
admet-373	62	43	by	by	ADP
admet-373	62	44	hplc	hplc	NOUN
admet-373	62	45	(	(	PUNCT
admet-373	62	46	100*free	100*free	NUM
admet-373	62	47	plasma	plasma	NOUN
admet-373	62	48	conc	conc	NOUN
admet-373	62	49	/	/	SYM
admet-373	62	50	dose	dose	NOUN
admet-373	62	51	)	)	PUNCT
admet-373	62	52	dei	dei	NOUN
admet-373	62	53	drug	drug	NOUN
admet-373	62	54	efficiency	efficiency	NOUN
admet-373	62	55	index	index	NOUN
admet-373	62	56	,	,	PUNCT
admet-373	62	57	potency	potency	NOUN
admet-373	62	58	plus	plus	CCONJ
admet-373	62	59	log	log	NOUN
admet-373	62	60	demax	demax	NOUN
admet-373	62	61	(	(	PUNCT
admet-373	62	62	pic50	pic50	NOUN
admet-373	62	63	+	+	NOUN
admet-373	62	64	log	log	NOUN
admet-373	62	65	de	de	X
admet-373	62	66	)	)	PUNCT
admet-373	62	67	iam	iam	PROPN
admet-373	62	68	mb	mb	ADP
admet-373	62	69	membrane	membrane	NOUN
admet-373	62	70	binding	bind	VERB
admet-373	62	71	index	index	NOUN
admet-373	62	72	,	,	PUNCT
admet-373	62	73	previously	previously	ADV
admet-373	62	74	known	know	VERB
admet-373	62	75	as	as	ADP
admet-373	62	76	chi(iam	chi(iam	NOUN
admet-373	62	77	)	)	PUNCT
admet-373	62	78	clogp	clogp	NOUN
admet-373	62	79	calculated	calculate	VERB
admet-373	62	80	logarithm	logarithm	NOUN
admet-373	62	81	of	of	ADP
admet-373	62	82	octanol	octanol	NOUN
admet-373	62	83	/	/	SYM
admet-373	62	84	water	water	NOUN
admet-373	62	85	partition	partition	NOUN
admet-373	62	86	coefficient	coefficient	NOUN
admet-373	62	87	log	log	VERB
admet-373	63	1	d	d	NOUN
admet-373	63	2	/	/	SYM
admet-373	63	3	p	p	NOUN
admet-373	63	4	logarithm	logarithm	NOUN
admet-373	63	5	of	of	ADP
admet-373	63	6	distribution	distribution	NOUN
admet-373	63	7	/	/	SYM
admet-373	63	8	partition	partition	NOUN
admet-373	63	9	coefficient	coefficient	NOUN
admet-373	63	10	table	table	NOUN
admet-373	63	11	2	2	NUM
admet-373	63	12	.	.	PUNCT
admet-373	64	1	equations	equation	NOUN
admet-373	64	2	used	use	VERB
admet-373	64	3	to	to	PART
admet-373	64	4	predict	predict	VERB
admet-373	64	5	distribution	distribution	NOUN
admet-373	64	6	properties	property	NOUN
admet-373	64	7	log	log	VERB
admet-373	64	8	k(iam	k(iam	PROPN
admet-373	64	9	)	)	PUNCT
admet-373	64	10	;	;	PUNCT
admet-373	65	1	eq	eq	X
admet-373	65	2	.	.	PUNCT
admet-373	66	1	(	(	PUNCT
admet-373	66	2	1	1	X
admet-373	66	3	)	)	PUNCT
admet-373	66	4	=	=	SYM
admet-373	66	5	0.29*e	0.29*e	NUM
admet-373	66	6	(	(	PUNCT
admet-373	66	7	0.026mb+0.42	0.026mb+0.42	NUM
admet-373	66	8	)	)	PUNCT
admet-373	66	9	+0.7	+0.7	NUM
admet-373	66	10	log	log	NOUN
admet-373	66	11	k(hsa	k(hsa	NOUN
admet-373	66	12	)	)	PUNCT
admet-373	66	13	;	;	PUNCT
admet-373	67	1	eq	eq	X
admet-373	67	2	.	.	PUNCT
admet-373	68	1	(	(	PUNCT
admet-373	68	2	2	2	X
admet-373	68	3	)	)	PUNCT
admet-373	68	4	=	=	SYM
admet-373	68	5	e	e	NOUN
admet-373	68	6	log	log	NOUN
admet-373	68	7	k(hsa	k(hsa	NOUN
admet-373	68	8	)	)	PUNCT
admet-373	68	9	log	log	NOUN
admet-373	68	10	k(hsa	k(hsa	NOUN
admet-373	68	11	)	)	PUNCT
admet-373	69	1	=	=	SYM
admet-373	69	2	log(%hsabound/(101%hsa	log(%hsabound/(101%hsa	PROPN
admet-373	69	3	bound	bind	VERB
admet-373	69	4	)	)	PUNCT
admet-373	69	5	)	)	PUNCT
admet-373	70	1	estimated	estimate	VERB
admet-373	70	2	log	log	NOUN
admet-373	70	3	vdss	vdss	ADV
admet-373	70	4	;	;	PUNCT
admet-373	71	1	eq	eq	X
admet-373	71	2	.	.	PUNCT
admet-373	72	1	(	(	PUNCT
admet-373	72	2	3	3	X
admet-373	72	3	)	)	PUNCT
admet-373	72	4	=	=	SYM
admet-373	72	5	0.44*log	0.44*log	PROPN
admet-373	72	6	k(iam	k(iam	PROPN
admet-373	72	7	)	)	PUNCT
admet-373	72	8	-0.22*log	-0.22*log	PUNCT
admet-373	72	9	k(hsa	k(hsa	PROPN
admet-373	72	10	)	)	PUNCT
admet-373	72	11	–	–	PUNCT
admet-373	72	12	0.62	0.62	NUM
admet-373	72	13	estimated	estimate	VERB
admet-373	72	14	log	log	PROPN
admet-373	72	15	vdu	vdu	PROPN
admet-373	72	16	;	;	PUNCT
admet-373	72	17	eq	eq	ADP
admet-373	72	18	.	.	PUNCT
admet-373	73	1	(	(	PUNCT
admet-373	73	2	4	4	X
admet-373	73	3	)	)	PUNCT
admet-373	73	4	=	=	SYM
admet-373	73	5	0.23*log	0.23*log	PROPN
admet-373	73	6	k(hsa	k(hsa	PROPN
admet-373	73	7	)	)	PUNCT
admet-373	73	8	+0.43*log	+0.43*log	PROPN
admet-373	73	9	k(iam	k(iam	PROPN
admet-373	73	10	)	)	PUNCT
admet-373	73	11	-0.72	-0.72	PROPN
admet-373	73	12	demax	demax	NOUN
admet-373	73	13	;	;	PUNCT
admet-373	74	1	eq	eq	X
admet-373	74	2	.	.	PUNCT
admet-373	75	1	(	(	PUNCT
admet-373	75	2	7	7	X
admet-373	75	3	)	)	PUNCT
admet-373	75	4	=	=	SYM
admet-373	75	5	100	100	NUM
admet-373	75	6	/	/	SYM
admet-373	75	7	vdu	vdu	PROPN
admet-373	75	8	lle	lle	PROPN
admet-373	75	9	ligand	ligand	NOUN
admet-373	75	10	lipophilicity	lipophilicity	NOUN
admet-373	75	11	efficiency	efficiency	NOUN
admet-373	75	12	(	(	PUNCT
admet-373	75	13	pic50	pic50	NOUN
admet-373	75	14	-clogp	-clogp	NOUN
admet-373	75	15	)	)	PUNCT
admet-373	75	16	log	log	NOUN
admet-373	75	17	k	k	PROPN
admet-373	75	18	(	(	PUNCT
admet-373	75	19	ppb	ppb	NOUN
admet-373	75	20	)	)	PUNCT
admet-373	75	21	(	(	PUNCT
admet-373	75	22	8)	8)	NUM
admet-373	75	23	0.87	0.87	NUM
admet-373	75	24	∗	∗	NOUN
admet-373	75	25	log	log	NOUN
admet-373	75	26	𝑘(𝐻𝑆𝐴	𝑘(𝐻𝑆𝐴	PROPN
admet-373	75	27	)	)	PUNCT
admet-373	75	28	+	+	NUM
admet-373	75	29	0.17	0.17	NUM
admet-373	75	30	∗	∗	NOUN
admet-373	75	31	log	log	NOUN
admet-373	75	32	𝑘(𝐴𝐺𝑃	𝑘(𝐴𝐺𝑃	NOUN
admet-373	75	33	)	)	PUNCT
admet-373	76	1	+	+	CCONJ
admet-373	76	2	0.06	0.06	NUM
admet-373	76	3	∗	∗	NOUN
admet-373	76	4	𝑐𝑀𝑅	𝑐𝑀𝑅	CCONJ
admet-373	76	5	−	−	PROPN
admet-373	76	6	0.27	0.27	NUM
admet-373	76	7	lipophilicity	lipophilicity	NOUN
admet-373	76	8	has	have	AUX
admet-373	76	9	been	be	AUX
admet-373	76	10	historically	historically	ADV
admet-373	76	11	characterised	characterise	VERB
admet-373	76	12	by	by	ADP
admet-373	76	13	the	the	DET
admet-373	76	14	octanol	octanol	NOUN
admet-373	76	15	/	/	SYM
admet-373	76	16	water	water	NOUN
admet-373	76	17	partition	partition	NOUN
admet-373	76	18	coefficient	coefficient	NOUN
admet-373	76	19	,	,	PUNCT
admet-373	76	20	log	log	VERB
admet-373	76	21	p	p	NOUN
admet-373	76	22	,	,	PUNCT
admet-373	76	23	for	for	ADP
admet-373	76	24	the	the	DET
admet-373	76	25	neutral	neutral	ADJ
admet-373	76	26	form	form	NOUN
admet-373	76	27	of	of	ADP
admet-373	76	28	the	the	DET
admet-373	76	29	molecules	molecule	NOUN
admet-373	76	30	and	and	CCONJ
admet-373	76	31	by	by	ADP
admet-373	76	32	the	the	DET
admet-373	76	33	distribution	distribution	NOUN
admet-373	76	34	coefficient	coefficient	NOUN
admet-373	76	35	,	,	PUNCT
admet-373	76	36	log	log	PROPN
admet-373	76	37	d	d	PROPN
admet-373	76	38	,	,	PUNCT
admet-373	76	39	measured	measure	VERB
admet-373	76	40	at	at	ADP
admet-373	76	41	different	different	ADJ
admet-373	76	42	phs	phs	NOUN
admet-373	76	43	,	,	PUNCT
admet-373	76	44	mainly	mainly	ADV
admet-373	76	45	at	at	ADP
admet-373	76	46	ph	ph	PROPN
admet-373	76	47	7.4	7.4	NUM
admet-373	76	48	.	.	PUNCT
admet-373	77	1	log	log	NOUN
admet-373	77	2	p	p	NOUN
admet-373	77	3	is	be	AUX
admet-373	77	4	widely	widely	ADV
admet-373	77	5	used	use	VERB
admet-373	77	6	since	since	SCONJ
admet-373	77	7	the	the	DET
admet-373	77	8	work	work	NOUN
admet-373	77	9	of	of	ADP
admet-373	77	10	hansch	hansch	NOUN
admet-373	78	1	[	[	X
admet-373	78	2	28	28	NUM
admet-373	78	3	]	]	PUNCT
admet-373	78	4	who	who	PRON
admet-373	78	5	suggested	suggest	VERB
admet-373	78	6	log	log	NOUN
admet-373	78	7	p	p	NOUN
admet-373	78	8	to	to	PART
admet-373	78	9	describe	describe	VERB
admet-373	78	10	the	the	DET
admet-373	78	11	so	so	ADV
admet-373	78	12	-	-	PUNCT
admet-373	78	13	called	call	VERB
admet-373	78	14	“	"	PUNCT
admet-373	78	15	random	random	ADJ
admet-373	78	16	”	"	PUNCT
admet-373	78	17	walk	walk	NOUN
admet-373	78	18	of	of	ADP
admet-373	78	19	the	the	DET
admet-373	78	20	drug	drug	NOUN
admet-373	78	21	molecule	molecule	NOUN
admet-373	78	22	that	that	PRON
admet-373	78	23	reduces	reduce	VERB
admet-373	78	24	its	its	PRON
admet-373	78	25	free	free	ADJ
admet-373	78	26	concentration	concentration	NOUN
admet-373	78	27	near	near	ADP
admet-373	78	28	the	the	DET
admet-373	78	29	receptor	receptor	NOUN
admet-373	78	30	.	.	PUNCT
admet-373	79	1	lipophilic	lipophilic	ADJ
admet-373	79	2	compounds	compound	NOUN
admet-373	79	3	energetically	energetically	ADV
admet-373	79	4	do	do	AUX
admet-373	79	5	not	not	PART
admet-373	79	6	favour	favour	VERB
admet-373	79	7	residing	reside	VERB
admet-373	79	8	in	in	ADP
admet-373	79	9	the	the	DET
admet-373	79	10	aqueous	aqueous	ADJ
admet-373	79	11	environment	environment	NOUN
admet-373	79	12	and	and	CCONJ
admet-373	79	13	have	have	VERB
admet-373	79	14	a	a	DET
admet-373	79	15	preference	preference	NOUN
admet-373	79	16	to	to	PART
admet-373	79	17	“	"	PUNCT
admet-373	79	18	stick	stick	VERB
admet-373	79	19	”	"	PUNCT
admet-373	79	20	to	to	ADP
admet-373	79	21	any	any	DET
admet-373	79	22	hydrophobic	hydrophobic	NOUN
admet-373	79	23	surface	surface	NOUN
admet-373	79	24	in	in	ADP
admet-373	79	25	the	the	DET
admet-373	79	26	body	body	NOUN
admet-373	79	27	.	.	PUNCT
admet-373	80	1	the	the	DET
admet-373	80	2	octanol	octanol	NOUN
admet-373	80	3	/	/	SYM
admet-373	80	4	water	water	NOUN
admet-373	80	5	system	system	NOUN
admet-373	80	6	is	be	AUX
admet-373	80	7	able	able	ADJ
admet-373	80	8	to	to	PART
admet-373	80	9	partially	partially	ADV
admet-373	80	10	mimic	mimic	VERB
admet-373	80	11	the	the	DET
admet-373	80	12	polar	polar	ADJ
admet-373	80	13	groups	group	NOUN
admet-373	80	14	with	with	ADP
admet-373	80	15	hydrogen	hydrogen	NOUN
admet-373	80	16	bond	bond	NOUN
admet-373	80	17	donor	donor	NOUN
admet-373	80	18	and	and	CCONJ
admet-373	80	19	acceptor	acceptor	NOUN
admet-373	80	20	properties	property	NOUN
admet-373	80	21	that	that	PRON
admet-373	80	22	may	may	AUX
admet-373	80	23	be	be	AUX
admet-373	80	24	present	present	ADJ
admet-373	80	25	in	in	ADP
admet-373	80	26	the	the	DET
admet-373	80	27	lipophilic	lipophilic	ADJ
admet-373	80	28	environment	environment	NOUN
admet-373	80	29	in	in	ADP
admet-373	80	30	the	the	DET
admet-373	80	31	body	body	NOUN
admet-373	80	32	and	and	CCONJ
admet-373	80	33	therefore	therefore	ADV
admet-373	80	34	serve	serve	VERB
admet-373	80	35	as	as	ADP
admet-373	80	36	a	a	DET
admet-373	80	37	good	good	ADJ
admet-373	80	38	model	model	NOUN
admet-373	80	39	to	to	PART
admet-373	80	40	describe	describe	VERB
admet-373	80	41	biological	biological	ADJ
admet-373	80	42	distribution	distribution	NOUN
admet-373	80	43	.	.	PUNCT
admet-373	81	1	however	however	ADV
admet-373	81	2	,	,	PUNCT
admet-373	81	3	the	the	DET
admet-373	81	4	octanol	octanol	NOUN
admet-373	81	5	/	/	SYM
admet-373	81	6	water	water	NOUN
admet-373	81	7	lipophilicity	lipophilicity	NOUN
admet-373	81	8	and	and	CCONJ
admet-373	81	9	any	any	DET
admet-373	81	10	other	other	ADJ
admet-373	81	11	lipophilicity	lipophilicity	NOUN
admet-373	81	12	measure	measure	NOUN
admet-373	81	13	that	that	PRON
admet-373	81	14	does	do	AUX
admet-373	81	15	not	not	PART
admet-373	81	16	include	include	VERB
admet-373	81	17	cellular	cellular	ADJ
admet-373	81	18	membranes	membrane	NOUN
admet-373	81	19	and	and	CCONJ
admet-373	81	20	proteins	protein	NOUN
admet-373	81	21	,	,	PUNCT
admet-373	81	22	fails	fail	VERB
admet-373	81	23	to	to	PART
admet-373	81	24	explain	explain	VERB
admet-373	81	25	the	the	DET
admet-373	81	26	biological	biological	ADJ
admet-373	81	27	distribution	distribution	NOUN
admet-373	81	28	of	of	ADP
admet-373	81	29	molecules	molecule	NOUN
admet-373	81	30	when	when	SCONJ
admet-373	81	31	they	they	PRON
admet-373	81	32	have	have	AUX
admet-373	81	33	charge	charge	NOUN
admet-373	81	34	or	or	CCONJ
admet-373	81	35	special	special	ADJ
admet-373	81	36	shape	shape	NOUN
admet-373	81	37	.	.	PUNCT
admet-373	82	1	an	an	DET
admet-373	82	2	example	example	NOUN
admet-373	82	3	is	be	AUX
admet-373	82	4	the	the	DET
admet-373	82	5	comparison	comparison	NOUN
admet-373	82	6	of	of	ADP
admet-373	82	7	nifedipine	nifedipine	NOUN
admet-373	82	8	and	and	CCONJ
admet-373	82	9	amlodipine	amlodipine	NOUN
admet-373	82	10	(	(	PUNCT
admet-373	82	11	see	see	VERB
admet-373	82	12	figure	figure	NOUN
admet-373	82	13	1	1	NUM
admet-373	82	14	)	)	PUNCT
admet-373	82	15	.	.	PUNCT
admet-373	83	1	nifedipine	nifedipine	PROPN
admet-373	83	2	is	be	AUX
admet-373	83	3	more	more	ADV
admet-373	83	4	lipophilic	lipophilic	ADJ
admet-373	83	5	at	at	ADP
admet-373	83	6	physiological	physiological	ADJ
admet-373	83	7	ph	ph	NOUN
admet-373	83	8	but	but	CCONJ
admet-373	83	9	still	still	ADV
admet-373	83	10	,	,	PUNCT
admet-373	83	11	the	the	DET
admet-373	83	12	volume	volume	NOUN
admet-373	83	13	of	of	ADP
admet-373	83	14	distribution	distribution	NOUN
admet-373	83	15	of	of	ADP
admet-373	83	16	amlodipine	amlodipine	NOUN
admet-373	83	17	is	be	AUX
admet-373	83	18	30	30	NUM
admet-373	83	19	times	time	NOUN
admet-373	83	20	higher	high	ADJ
admet-373	83	21	,	,	PUNCT
admet-373	83	22	indicating	indicate	VERB
admet-373	83	23	30	30	NUM
admet-373	83	24	times	time	NOUN
admet-373	83	25	higher	high	ADJ
admet-373	83	26	partitioning	partitioning	NOUN
admet-373	83	27	to	to	ADP
admet-373	83	28	tissues	tissue	NOUN
admet-373	83	29	then	then	ADV
admet-373	83	30	nifedipine	nifedipine	PROPN
admet-373	83	31	.	.	PUNCT
admet-373	84	1	the	the	DET
admet-373	84	2	clearance	clearance	NOUN
admet-373	84	3	of	of	ADP
admet-373	84	4	nifedipine	nifedipine	NOUN
admet-373	84	5	is	be	AUX
admet-373	84	6	9.8	9.8	NUM
admet-373	84	7	ml	ml	NOUN
admet-373	84	8	/	/	SYM
admet-373	84	9	min	min	NOUN
admet-373	84	10	/	/	SYM
admet-373	84	11	kg	kg	PROPN
admet-373	85	1	[	[	X
admet-373	85	2	29	29	NUM
admet-373	85	3	]	]	PUNCT
admet-373	85	4	,	,	PUNCT
admet-373	85	5	and	and	CCONJ
admet-373	85	6	clearance	clearance	NOUN
admet-373	85	7	of	of	ADP
admet-373	85	8	amlodipine	amlodipine	NOUN
admet-373	85	9	is	be	AUX
admet-373	85	10	in	in	ADP
admet-373	85	11	a	a	DET
admet-373	85	12	similar	similar	ADJ
admet-373	85	13	range	range	NOUN
admet-373	85	14	,	,	PUNCT
admet-373	85	15	7	7	NUM
admet-373	85	16	ml	ml	NOUN
admet-373	85	17	/	/	SYM
admet-373	85	18	min	min	NOUN
admet-373	85	19	/	/	SYM
admet-373	85	20	kg	kg	PROPN
admet-373	86	1	[	[	X
admet-373	86	2	30	30	NUM
admet-373	86	3	]	]	PUNCT
admet-373	86	4	.	.	PUNCT
admet-373	87	1	the	the	DET
admet-373	87	2	major	major	ADJ
admet-373	87	3	difference	difference	NOUN
admet-373	87	4	between	between	ADP
admet-373	87	5	the	the	DET
admet-373	87	6	two	two	NUM
admet-373	87	7	valko	valko	NOUN
admet-373	87	8	,	,	PUNCT
admet-373	87	9	teague	teague	NOUN
admet-373	87	10	and	and	CCONJ
admet-373	87	11	pidgeon	pidgeon	PROPN
admet-373	87	12	admet	admet	PROPN
admet-373	87	13	&	&	CCONJ
admet-373	87	14	dmpk	dmpk	PROPN
admet-373	87	15	5(1	5(1	NUM
admet-373	87	16	)	)	PUNCT
admet-373	87	17	(	(	PUNCT
admet-373	87	18	2017	2017	NUM
admet-373	87	19	)	)	PUNCT
admet-373	87	20	14	14	NUM
admet-373	87	21	-	-	SYM
admet-373	87	22	38	38	NUM
admet-373	87	23	18	18	NUM
admet-373	87	24	molecules	molecule	NOUN
admet-373	87	25	is	be	AUX
admet-373	87	26	a	a	DET
admet-373	87	27	basic	basic	ADJ
admet-373	87	28	amine	amine	ADJ
admet-373	87	29	group	group	NOUN
admet-373	87	30	on	on	ADP
admet-373	87	31	amlodipine	amlodipine	NOUN
admet-373	87	32	.	.	PUNCT
admet-373	88	1	the	the	DET
admet-373	88	2	basic	basic	ADJ
admet-373	88	3	group	group	NOUN
admet-373	88	4	results	result	VERB
admet-373	88	5	in	in	ADP
admet-373	88	6	amlodipine	amlodipine	NOUN
admet-373	88	7	having	have	VERB
admet-373	88	8	a	a	DET
admet-373	88	9	stronger	strong	ADJ
admet-373	88	10	binding	binding	NOUN
admet-373	88	11	to	to	ADP
admet-373	88	12	phospholipids	phospholipid	NOUN
admet-373	88	13	than	than	ADP
admet-373	88	14	albumin	albumin	NOUN
admet-373	88	15	,	,	PUNCT
admet-373	88	16	and	and	CCONJ
admet-373	88	17	this	this	DET
admet-373	88	18	results	result	NOUN
admet-373	88	19	in	in	ADP
admet-373	88	20	a	a	DET
admet-373	88	21	large	large	ADJ
admet-373	88	22	difference	difference	NOUN
admet-373	88	23	in	in	ADP
admet-373	88	24	their	their	PRON
admet-373	88	25	volumes	volume	NOUN
admet-373	88	26	of	of	ADP
admet-373	88	27	distribution	distribution	NOUN
admet-373	88	28	.	.	PUNCT
admet-373	89	1	figure	figure	NOUN
admet-373	89	2	1	1	NUM
admet-373	89	3	.	.	PUNCT
admet-373	89	4	physico	physico	NOUN
admet-373	89	5	-	-	PUNCT
admet-373	89	6	chemical	chemical	ADJ
admet-373	89	7	and	and	CCONJ
admet-373	89	8	biomimetic	biomimetic	ADJ
admet-373	89	9	properties	property	NOUN
admet-373	89	10	of	of	ADP
admet-373	89	11	nifedipine	nifedipine	NOUN
admet-373	89	12	and	and	CCONJ
admet-373	89	13	amlodipine	amlodipine	NOUN
admet-373	89	14	besides	besides	SCONJ
admet-373	89	15	measuring	measure	VERB
admet-373	89	16	the	the	DET
admet-373	89	17	octanol	octanol	NOUN
admet-373	89	18	/	/	SYM
admet-373	89	19	water	water	NOUN
admet-373	89	20	partition	partition	NOUN
admet-373	89	21	coefficients	coefficient	NOUN
admet-373	89	22	we	we	PRON
admet-373	89	23	propose	propose	VERB
admet-373	89	24	a	a	DET
admet-373	89	25	method	method	NOUN
admet-373	89	26	of	of	ADP
admet-373	89	27	measuring	measure	VERB
admet-373	89	28	the	the	DET
admet-373	89	29	protein	protein	NOUN
admet-373	89	30	and	and	CCONJ
admet-373	89	31	phospholipid	phospholipid	NOUN
admet-373	89	32	binding	bind	VERB
admet-373	89	33	of	of	ADP
admet-373	89	34	the	the	DET
admet-373	89	35	compounds	compound	NOUN
admet-373	89	36	using	use	VERB
admet-373	89	37	reverse	reverse	NOUN
admet-373	89	38	phase	phase	NOUN
admet-373	89	39	high	high	ADJ
admet-373	89	40	-	-	PUNCT
admet-373	89	41	performance	performance	NOUN
admet-373	89	42	liquid	liquid	ADJ
admet-373	89	43	chromatography	chromatography	NOUN
admet-373	89	44	in	in	ADP
admet-373	89	45	conjunction	conjunction	NOUN
admet-373	89	46	with	with	ADP
admet-373	89	47	the	the	DET
admet-373	89	48	membrane	membrane	NOUN
admet-373	89	49	binding	bind	VERB
admet-373	89	50	/	/	SYM
admet-373	89	51	protein	protein	NOUN
admet-373	89	52	binding	bind	VERB
admet-373	89	53	technology	technology	NOUN
admet-373	89	54	(	(	PUNCT
admet-373	89	55	mb	mb	NOUN
admet-373	89	56	/	/	SYM
admet-373	89	57	pb	pb	ADP
admet-373	89	58	technology	technology	NOUN
admet-373	89	59	®	®	NOUN
admet-373	89	60	)	)	PUNCT
admet-373	89	61	registered	register	VERB
admet-373	89	62	to	to	ADP
admet-373	89	63	regis	regis	PROPN
admet-373	89	64	technologies	technologies	PROPN
admet-373	89	65	inc	inc	PROPN
admet-373	89	66	.	.	PROPN
admet-373	89	67	using	use	VERB
admet-373	89	68	this	this	DET
admet-373	89	69	approach	approach	NOUN
admet-373	89	70	,	,	PUNCT
admet-373	89	71	we	we	PRON
admet-373	89	72	can	can	AUX
admet-373	89	73	measure	measure	VERB
admet-373	89	74	compounds	compound	VERB
admet-373	89	75	interaction	interaction	NOUN
admet-373	89	76	with	with	ADP
admet-373	89	77	phosphatidylcholine	phosphatidylcholine	NOUN
admet-373	89	78	membrane	membrane	NOUN
admet-373	89	79	(	(	PUNCT
admet-373	89	80	iam	iam	PROPN
admet-373	89	81	)	)	PUNCT
admet-373	89	82	,	,	PUNCT
admet-373	89	83	human	human	ADJ
admet-373	89	84	serum	serum	NOUN
admet-373	89	85	albumin	albumin	PROPN
admet-373	89	86	(	(	PUNCT
admet-373	89	87	hsa	hsa	PROPN
admet-373	89	88	)	)	PUNCT
admet-373	89	89	and	and	CCONJ
admet-373	89	90	alpha-1	alpha-1	NOUN
admet-373	89	91	-	-	PUNCT
admet-373	89	92	acid	acid	NOUN
admet-373	89	93	glycoprotein	glycoprotein	NOUN
admet-373	89	94	(	(	PUNCT
admet-373	89	95	agp	agp	NOUN
admet-373	89	96	)	)	PUNCT
admet-373	89	97	.	.	PUNCT
admet-373	90	1	these	these	PRON
admet-373	90	2	are	be	AUX
admet-373	90	3	commercially	commercially	ADV
admet-373	90	4	available	available	ADJ
admet-373	90	5	hplc	hplc	NOUN
admet-373	90	6	stationary	stationary	ADJ
admet-373	90	7	phases	phase	NOUN
admet-373	90	8	that	that	PRON
admet-373	90	9	contain	contain	VERB
admet-373	90	10	or	or	CCONJ
admet-373	90	11	mimic	mimic	VERB
admet-373	90	12	these	these	DET
admet-373	90	13	constituents	constituent	NOUN
admet-373	90	14	of	of	ADP
admet-373	90	15	the	the	DET
admet-373	90	16	body	body	NOUN
admet-373	90	17	.	.	PUNCT
admet-373	91	1	these	these	PRON
admet-373	91	2	include	include	VERB
admet-373	91	3	(	(	PUNCT
admet-373	91	4	i	i	NOUN
admet-373	91	5	)	)	PUNCT
admet-373	91	6	iams	iam	NOUN
admet-373	91	7	,	,	PUNCT
admet-373	91	8	(	(	PUNCT
admet-373	91	9	ii	ii	NOUN
admet-373	91	10	)	)	PUNCT
admet-373	91	11	chiral	chiral	ADJ
admet-373	91	12	hsa	hsa	PROPN
admet-373	91	13	and	and	CCONJ
admet-373	91	14	(	(	PUNCT
admet-373	91	15	iii	iii	NOUN
admet-373	91	16	)	)	PUNCT
admet-373	91	17	chrial	chrial	ADJ
admet-373	91	18	agp	agp	PROPN
admet-373	91	19	.	.	PUNCT
admet-373	92	1	the	the	DET
admet-373	92	2	iam	iam	PROPN
admet-373	92	3	concept	concept	NOUN
admet-373	92	4	was	be	AUX
admet-373	92	5	introduced	introduce	VERB
admet-373	92	6	by	by	ADP
admet-373	92	7	pidgeon	pidgeon	NOUN
admet-373	92	8	et	et	PROPN
admet-373	92	9	al	al	PROPN
admet-373	92	10	.	.	PUNCT
admet-373	93	1	[	[	X
admet-373	93	2	31	31	NUM
admet-373	93	3	-	-	SYM
admet-373	93	4	33	33	NUM
admet-373	93	5	]	]	PUNCT
admet-373	93	6	and	and	CCONJ
admet-373	93	7	it	it	PRON
admet-373	93	8	was	be	AUX
admet-373	93	9	the	the	DET
admet-373	93	10	first	first	ADJ
admet-373	93	11	attempt	attempt	NOUN
admet-373	93	12	to	to	PART
admet-373	93	13	emulate	emulate	VERB
admet-373	93	14	the	the	DET
admet-373	93	15	biological	biological	ADJ
admet-373	93	16	membrane	membrane	NOUN
admet-373	93	17	on	on	ADP
admet-373	93	18	a	a	DET
admet-373	93	19	solid	solid	ADJ
admet-373	93	20	surface	surface	NOUN
admet-373	93	21	.	.	PUNCT
admet-373	94	1	hplc	hplc	NOUN
admet-373	94	2	columns	column	NOUN
admet-373	94	3	with	with	ADP
admet-373	94	4	iam	iam	PROPN
admet-373	94	5	stationary	stationary	ADJ
admet-373	94	6	phase	phase	NOUN
admet-373	94	7	where	where	SCONJ
admet-373	94	8	the	the	DET
admet-373	94	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-373	94	10	moiety	moiety	NOUN
admet-373	94	11	is	be	AUX
admet-373	94	12	chemically	chemically	ADV
admet-373	94	13	bonded	bond	VERB
admet-373	94	14	to	to	ADP
admet-373	94	15	a	a	DET
admet-373	94	16	solid	solid	ADJ
admet-373	94	17	surface	surface	NOUN
admet-373	94	18	mimic	mimic	VERB
admet-373	94	19	the	the	DET
admet-373	94	20	density	density	NOUN
admet-373	94	21	of	of	ADP
admet-373	94	22	phosphatidylcholine	phosphatidylcholine	NOUN
admet-373	94	23	in	in	ADP
admet-373	94	24	the	the	DET
admet-373	94	25	biological	biological	ADJ
admet-373	94	26	membrane	membrane	NOUN
admet-373	94	27	bi	bi	NOUN
admet-373	94	28	-	-	NOUN
admet-373	94	29	layer	layer	NOUN
admet-373	94	30	.	.	PUNCT
admet-373	95	1	other	other	ADJ
admet-373	95	2	approaches	approach	NOUN
admet-373	95	3	do	do	AUX
admet-373	95	4	exist	exist	VERB
admet-373	95	5	for	for	ADP
admet-373	95	6	measuring	measure	VERB
admet-373	95	7	membrane	membrane	NOUN
admet-373	95	8	binding	bind	VERB
admet-373	95	9	such	such	ADJ
admet-373	95	10	as	as	ADP
admet-373	95	11	using	use	VERB
admet-373	95	12	liposome	liposome	NOUN
admet-373	95	13	partition	partition	NOUN
admet-373	95	14	measurements	measurement	NOUN
admet-373	95	15	or	or	CCONJ
admet-373	95	16	micellar	micellar	ADJ
admet-373	95	17	electrophoresis	electrophoresis	NOUN
admet-373	95	18	[	[	X
admet-373	95	19	35	35	NUM
admet-373	95	20	-	-	SYM
admet-373	95	21	36	36	NUM
admet-373	95	22	]	]	PUNCT
admet-373	95	23	.	.	PUNCT
admet-373	96	1	however	however	ADV
admet-373	96	2	,	,	PUNCT
admet-373	96	3	they	they	PRON
admet-373	96	4	have	have	VERB
admet-373	96	5	their	their	PRON
admet-373	96	6	limitations	limitation	NOUN
admet-373	96	7	and	and	CCONJ
admet-373	96	8	are	be	AUX
admet-373	96	9	also	also	ADV
admet-373	96	10	very	very	ADV
admet-373	96	11	time	time	NOUN
admet-373	96	12	-	-	PUNCT
admet-373	96	13	consuming	consume	VERB
admet-373	96	14	.	.	PUNCT
admet-373	97	1	biomimetic	biomimetic	ADJ
admet-373	97	2	stationary	stationary	ADJ
admet-373	97	3	phases	phase	NOUN
admet-373	97	4	have	have	AUX
admet-373	97	5	been	be	AUX
admet-373	97	6	validated	validate	VERB
admet-373	97	7	by	by	ADP
admet-373	97	8	comparing	compare	VERB
admet-373	97	9	the	the	DET
admet-373	97	10	retention	retention	NOUN
admet-373	97	11	times	time	NOUN
admet-373	97	12	obtained	obtain	VERB
admet-373	97	13	on	on	ADP
admet-373	97	14	the	the	DET
admet-373	97	15	commercially	commercially	ADV
admet-373	97	16	available	available	ADJ
admet-373	97	17	chiralpak	chiralpak	NOUN
admet-373	97	18	-	-	PUNCT
admet-373	97	19	hsa	hsa	PROPN
admet-373	97	20	[	[	X
admet-373	97	21	37	37	NUM
admet-373	97	22	-	-	SYM
admet-373	97	23	39	39	NUM
admet-373	97	24	]	]	PUNCT
admet-373	97	25	and	and	CCONJ
admet-373	97	26	chiralpak	chiralpak	PROPN
admet-373	97	27	-	-	ADJ
admet-373	97	28	agp	agp	PROPN
admet-373	97	29	[	[	X
admet-373	97	30	40	40	NUM
admet-373	97	31	-	-	SYM
admet-373	97	32	41	41	NUM
admet-373	97	33	]	]	PUNCT
admet-373	97	34	stationary	stationary	ADJ
admet-373	97	35	phases	phase	NOUN
admet-373	97	36	result	result	VERB
admet-373	97	37	in	in	ADP
admet-373	97	38	binding	bind	VERB
admet-373	97	39	values	value	NOUN
admet-373	97	40	that	that	PRON
admet-373	97	41	are	be	AUX
admet-373	97	42	proportional	proportional	ADJ
admet-373	97	43	to	to	ADP
admet-373	97	44	the	the	DET
admet-373	97	45	albumin	albumin	NOUN
admet-373	97	46	and	and	CCONJ
admet-373	97	47	agp	agp	NOUN
admet-373	97	48	binding	binding	NOUN
admet-373	97	49	of	of	ADP
admet-373	97	50	compounds	compound	NOUN
admet-373	97	51	obtained	obtain	VERB
admet-373	97	52	by	by	ADP
admet-373	97	53	equilibrium	equilibrium	NOUN
admet-373	97	54	dialysis	dialysis	NOUN
admet-373	97	55	.	.	PUNCT
admet-373	98	1	when	when	SCONJ
admet-373	98	2	using	use	VERB
admet-373	98	3	biomimetic	biomimetic	ADJ
admet-373	98	4	stationary	stationary	ADJ
admet-373	98	5	phases	phase	NOUN
admet-373	98	6	the	the	DET
admet-373	98	7	retention	retention	NOUN
admet-373	98	8	time	time	NOUN
admet-373	98	9	of	of	ADP
admet-373	98	10	the	the	DET
admet-373	98	11	compounds	compound	NOUN
admet-373	98	12	is	be	AUX
admet-373	98	13	directly	directly	ADV
admet-373	98	14	proportional	proportional	ADJ
admet-373	98	15	to	to	ADP
admet-373	98	16	the	the	DET
admet-373	98	17	dynamic	dynamic	ADJ
admet-373	98	18	equilibrium	equilibrium	NOUN
admet-373	98	19	constant	constant	ADJ
admet-373	98	20	between	between	ADP
admet-373	98	21	the	the	DET
admet-373	98	22	mobile	mobile	ADJ
admet-373	98	23	phase	phase	NOUN
admet-373	98	24	(	(	PUNCT
admet-373	98	25	buffer	buffer	NOUN
admet-373	98	26	at	at	ADP
admet-373	98	27	physiological	physiological	ADJ
admet-373	98	28	ph	ph	NOUN
admet-373	98	29	)	)	PUNCT
admet-373	98	30	and	and	CCONJ
admet-373	98	31	the	the	DET
admet-373	98	32	actual	actual	ADJ
admet-373	98	33	body	body	NOUN
admet-373	98	34	component	component	NOUN
admet-373	98	35	(	(	PUNCT
admet-373	98	36	membrane	membrane	NOUN
admet-373	98	37	and	and	CCONJ
admet-373	98	38	proteins	protein	NOUN
admet-373	98	39	)	)	PUNCT
admet-373	98	40	in	in	ADP
admet-373	98	41	the	the	DET
admet-373	98	42	stationary	stationary	ADJ
admet-373	98	43	phase	phase	NOUN
admet-373	98	44	.	.	PUNCT
admet-373	99	1	the	the	DET
admet-373	99	2	process	process	NOUN
admet-373	99	3	is	be	AUX
admet-373	99	4	very	very	ADV
admet-373	99	5	similar	similar	ADJ
admet-373	99	6	to	to	ADP
admet-373	99	7	the	the	DET
admet-373	99	8	biological	biological	ADJ
admet-373	99	9	distribution	distribution	NOUN
admet-373	99	10	processes	process	NOUN
admet-373	99	11	that	that	PRON
admet-373	99	12	are	be	AUX
admet-373	99	13	also	also	ADV
admet-373	99	14	dynamic	dynamic	ADJ
admet-373	99	15	(	(	PUNCT
admet-373	99	16	never	never	ADV
admet-373	99	17	in	in	ADP
admet-373	99	18	real	real	ADJ
admet-373	99	19	equilibrium	equilibrium	NOUN
admet-373	99	20	unless	unless	SCONJ
admet-373	99	21	at	at	ADP
admet-373	99	22	steady	steady	ADJ
admet-373	99	23	state	state	NOUN
admet-373	99	24	)	)	PUNCT
admet-373	99	25	and	and	CCONJ
admet-373	99	26	occurs	occur	VERB
admet-373	99	27	on	on	ADP
admet-373	99	28	the	the	DET
admet-373	99	29	surfaces	surface	NOUN
admet-373	99	30	of	of	ADP
admet-373	99	31	the	the	DET
admet-373	99	32	biomimetic	biomimetic	ADJ
admet-373	99	33	stationary	stationary	ADJ
admet-373	99	34	phases	phase	NOUN
admet-373	99	35	.	.	PUNCT
admet-373	100	1	the	the	DET
admet-373	100	2	measured	measured	ADJ
admet-373	100	3	membrane	membrane	NOUN
admet-373	100	4	binding	bind	VERB
admet-373	100	5	parameters	parameter	NOUN
admet-373	100	6	reflect	reflect	VERB
admet-373	100	7	the	the	DET
admet-373	100	8	threedimensional	threedimensional	ADJ
admet-373	100	9	nature	nature	NOUN
admet-373	100	10	of	of	ADP
admet-373	100	11	the	the	DET
admet-373	100	12	molecule	molecule	NOUN
admet-373	100	13	’s	’s	PART
admet-373	100	14	interaction	interaction	NOUN
admet-373	100	15	within	within	ADP
admet-373	100	16	an	an	DET
admet-373	100	17	in	in	ADP
admet-373	100	18	vivo	vivo	NOUN
admet-373	100	19	system	system	NOUN
admet-373	100	20	(	(	PUNCT
admet-373	100	21	the	the	DET
admet-373	100	22	drug	drug	NOUN
admet-373	100	23	,	,	PUNCT
admet-373	100	24	membrane	membrane	NOUN
admet-373	100	25	and	and	CCONJ
admet-373	100	26	protein	protein	NOUN
admet-373	100	27	admet	admet	NOUN
admet-373	100	28	&	&	CCONJ
admet-373	100	29	dmpk	dmpk	PROPN
admet-373	100	30	5(1	5(1	NUM
admet-373	100	31	)	)	PUNCT
admet-373	100	32	(	(	PUNCT
admet-373	100	33	2017	2017	NUM
admet-373	100	34	)	)	PUNCT
admet-373	100	35	14	14	NUM
admet-373	100	36	-	-	SYM
admet-373	100	37	38	38	NUM
admet-373	100	38	in	in	ADP
admet-373	100	39	vitro	vitro	X
admet-373	100	40	membrane	membrane	NOUN
admet-373	100	41	and	and	CCONJ
admet-373	100	42	protein	protein	NOUN
admet-373	100	43	binding	bind	VERB
admet-373	100	44	doi	doi	NOUN
admet-373	100	45	:	:	PUNCT
admet-373	100	46	10.5599	10.5599	NUM
admet-373	100	47	/	/	SYM
admet-373	100	48	admet.5.1.373	admet.5.1.373	NUM
admet-373	100	49	19	19	NUM
admet-373	100	50	stationary	stationary	ADJ
admet-373	100	51	phase	phase	NOUN
admet-373	100	52	)	)	PUNCT
admet-373	100	53	that	that	PRON
admet-373	100	54	has	have	AUX
admet-373	100	55	been	be	AUX
admet-373	100	56	demonstrated	demonstrate	VERB
admet-373	100	57	in	in	ADP
admet-373	100	58	the	the	DET
admet-373	100	59	literature	literature	NOUN
admet-373	100	60	[	[	X
admet-373	100	61	14	14	NUM
admet-373	100	62	]	]	PUNCT
admet-373	100	63	.	.	PUNCT
admet-373	101	1	the	the	DET
admet-373	101	2	chromatographic	chromatographic	ADJ
admet-373	101	3	technique	technique	NOUN
admet-373	101	4	to	to	PART
admet-373	101	5	measure	measure	VERB
admet-373	101	6	these	these	DET
admet-373	101	7	biomimetic	biomimetic	ADJ
admet-373	101	8	properties	property	NOUN
admet-373	101	9	has	have	VERB
admet-373	101	10	several	several	ADJ
admet-373	101	11	other	other	ADJ
admet-373	101	12	technical	technical	ADJ
admet-373	101	13	advantages	advantage	NOUN
admet-373	101	14	.	.	PUNCT
admet-373	102	1	it	it	PRON
admet-373	102	2	can	can	AUX
admet-373	102	3	be	be	AUX
admet-373	102	4	easily	easily	ADV
admet-373	102	5	automated	automate	VERB
admet-373	102	6	;	;	PUNCT
admet-373	102	7	there	there	PRON
admet-373	102	8	is	be	VERB
admet-373	102	9	no	no	DET
admet-373	102	10	need	need	NOUN
admet-373	102	11	for	for	ADP
admet-373	102	12	concentration	concentration	NOUN
admet-373	102	13	determination	determination	NOUN
admet-373	102	14	and	and	CCONJ
admet-373	102	15	measurements	measurement	NOUN
admet-373	102	16	.	.	PUNCT
admet-373	103	1	the	the	DET
admet-373	103	2	important	important	ADJ
admet-373	103	3	thing	thing	NOUN
admet-373	103	4	is	be	AUX
admet-373	103	5	,	,	PUNCT
admet-373	103	6	however	however	ADV
admet-373	103	7	,	,	PUNCT
admet-373	103	8	to	to	PART
admet-373	103	9	standardise	standardise	VERB
admet-373	103	10	the	the	DET
admet-373	103	11	retention	retention	NOUN
admet-373	103	12	times	time	NOUN
admet-373	103	13	and	and	CCONJ
admet-373	103	14	binding	bind	VERB
admet-373	103	15	data	datum	NOUN
admet-373	103	16	by	by	ADP
admet-373	103	17	measuring	measure	VERB
admet-373	103	18	a	a	DET
admet-373	103	19	calibration	calibration	NOUN
admet-373	103	20	set	set	NOUN
admet-373	103	21	of	of	ADP
admet-373	103	22	compounds	compound	NOUN
admet-373	103	23	with	with	ADP
admet-373	103	24	each	each	DET
admet-373	103	25	compound	compound	NOUN
admet-373	103	26	set	set	VERB
admet-373	103	27	to	to	PART
admet-373	103	28	be	be	AUX
admet-373	103	29	able	able	ADJ
admet-373	103	30	to	to	PART
admet-373	103	31	get	get	AUX
admet-373	103	32	normalised	normalise	VERB
admet-373	103	33	retention	retention	NOUN
admet-373	103	34	times	time	NOUN
admet-373	103	35	for	for	ADP
admet-373	103	36	each	each	PRON
admet-373	103	37	of	of	ADP
admet-373	103	38	the	the	DET
admet-373	103	39	stationary	stationary	ADJ
admet-373	103	40	phases	phase	NOUN
admet-373	103	41	being	be	AUX
admet-373	103	42	used	use	VERB
admet-373	103	43	to	to	PART
admet-373	103	44	generate	generate	VERB
admet-373	103	45	binding	binding	ADJ
admet-373	103	46	data	datum	NOUN
admet-373	103	47	(	(	PUNCT
admet-373	103	48	iam	iam	PROPN
admet-373	103	49	,	,	PUNCT
admet-373	103	50	hsa	hsa	PROPN
admet-373	103	51	and	and	CCONJ
admet-373	103	52	agp	agp	NOUN
admet-373	103	53	)	)	PUNCT
admet-373	103	54	.	.	PUNCT
admet-373	104	1	a	a	DET
admet-373	104	2	detailed	detailed	ADJ
admet-373	104	3	description	description	NOUN
admet-373	104	4	of	of	ADP
admet-373	104	5	the	the	DET
admet-373	104	6	standardised	standardised	ADJ
admet-373	104	7	methodology	methodology	NOUN
admet-373	104	8	for	for	ADP
admet-373	104	9	each	each	PRON
admet-373	104	10	of	of	ADP
admet-373	104	11	the	the	DET
admet-373	104	12	iam	iam	PROPN
admet-373	104	13	mb	mb	PROPN
admet-373	104	14	/	/	SYM
admet-373	104	15	pb	pb	X
admet-373	104	16	stationary	stationary	ADJ
admet-373	104	17	phases	phase	NOUN
admet-373	104	18	has	have	AUX
admet-373	104	19	recently	recently	ADV
admet-373	104	20	been	be	AUX
admet-373	104	21	published	publish	VERB
admet-373	104	22	[	[	PUNCT
admet-373	104	23	14	14	NUM
admet-373	104	24	]	]	PUNCT
admet-373	104	25	.	.	PUNCT
admet-373	105	1	there	there	PRON
admet-373	105	2	are	be	VERB
admet-373	105	3	several	several	ADJ
admet-373	105	4	publications	publication	NOUN
admet-373	105	5	establishing	establish	VERB
admet-373	105	6	the	the	DET
admet-373	105	7	usefulness	usefulness	NOUN
admet-373	105	8	of	of	ADP
admet-373	105	9	the	the	DET
admet-373	105	10	iam	iam	PROPN
admet-373	105	11	mb	mb	PROPN
admet-373	105	12	/	/	SYM
admet-373	105	13	pb	pb	ADP
admet-373	105	14	technology	technology	NOUN
admet-373	105	15	to	to	PART
admet-373	105	16	model	model	VERB
admet-373	105	17	in	in	ADP
admet-373	105	18	vivo	vivo	ADJ
admet-373	105	19	drug	drug	NOUN
admet-373	105	20	distribution	distribution	NOUN
admet-373	105	21	,	,	PUNCT
admet-373	105	22	such	such	ADJ
admet-373	105	23	as	as	ADP
admet-373	105	24	the	the	DET
admet-373	105	25	volume	volume	NOUN
admet-373	105	26	of	of	ADP
admet-373	105	27	distribution	distribution	NOUN
admet-373	105	28	model	model	NOUN
admet-373	105	29	[	[	X
admet-373	105	30	42	42	NUM
admet-373	105	31	]	]	PUNCT
admet-373	105	32	,	,	PUNCT
admet-373	105	33	unbound	unbound	ADJ
admet-373	105	34	volume	volume	NOUN
admet-373	105	35	of	of	ADP
admet-373	105	36	distribution	distribution	NOUN
admet-373	105	37	model	model	NOUN
admet-373	105	38	[	[	X
admet-373	105	39	43	43	NUM
admet-373	105	40	-	-	SYM
admet-373	105	41	44	44	NUM
admet-373	105	42	]	]	PUNCT
admet-373	105	43	and	and	CCONJ
admet-373	105	44	how	how	SCONJ
admet-373	105	45	they	they	PRON
admet-373	105	46	can	can	AUX
admet-373	105	47	be	be	AUX
admet-373	105	48	used	use	VERB
admet-373	105	49	to	to	PART
admet-373	105	50	screen	screen	VERB
admet-373	105	51	compounds	compound	NOUN
admet-373	105	52	in	in	ADP
admet-373	105	53	early	early	ADJ
admet-373	105	54	drug	drug	NOUN
admet-373	105	55	discovery	discovery	NOUN
admet-373	106	1	[	[	X
admet-373	106	2	45	45	NUM
admet-373	106	3	]	]	PUNCT
admet-373	106	4	.	.	PUNCT
admet-373	107	1	it	it	PRON
admet-373	107	2	was	be	AUX
admet-373	107	3	found	find	VERB
admet-373	107	4	that	that	SCONJ
admet-373	107	5	strong	strong	ADJ
admet-373	107	6	iam	iam	PROPN
admet-373	107	7	mb	mb	PROPN
admet-373	107	8	(	(	PUNCT
admet-373	107	9	chi	chi	PROPN
admet-373	107	10	iam	iam	PROPN
admet-373	107	11	>	>	X
admet-373	107	12	50	50	NUM
admet-373	107	13	)	)	PUNCT
admet-373	107	14	can	can	AUX
admet-373	107	15	be	be	AUX
admet-373	107	16	related	relate	VERB
admet-373	107	17	to	to	ADP
admet-373	107	18	phospholipidosis	phospholipidosis	NOUN
admet-373	107	19	[	[	X
admet-373	107	20	46	46	NUM
admet-373	107	21	-	-	SYM
admet-373	107	22	47	47	NUM
admet-373	107	23	]	]	PUNCT
admet-373	107	24	,	,	PUNCT
admet-373	107	25	as	as	ADV
admet-373	107	26	well	well	ADV
admet-373	107	27	as	as	ADP
admet-373	107	28	high	high	ADJ
admet-373	107	29	volume	volume	NOUN
admet-373	107	30	of	of	ADP
admet-373	107	31	distribution	distribution	NOUN
admet-373	107	32	and	and	CCONJ
admet-373	107	33	tissue	tissue	NOUN
admet-373	107	34	partitioning	partition	VERB
admet-373	107	35	[	[	X
admet-373	107	36	43	43	NUM
admet-373	107	37	]	]	PUNCT
admet-373	107	38	.	.	PUNCT
admet-373	108	1	recently	recently	ADV
admet-373	108	2	,	,	PUNCT
admet-373	108	3	it	it	PRON
admet-373	108	4	was	be	AUX
admet-373	108	5	found	find	VERB
admet-373	108	6	that	that	SCONJ
admet-373	108	7	promiscuity	promiscuity	NOUN
admet-373	108	8	(	(	PUNCT
admet-373	108	9	i.e.	i.e.	X
admet-373	108	10	,	,	PUNCT
admet-373	108	11	a	a	DET
admet-373	108	12	discovery	discovery	NOUN
admet-373	108	13	compound	compound	NOUN
admet-373	108	14	binding	bind	VERB
admet-373	108	15	to	to	ADP
admet-373	108	16	multiple	multiple	ADJ
admet-373	108	17	receptors	receptor	NOUN
admet-373	108	18	)	)	PUNCT
admet-373	108	19	showed	show	VERB
admet-373	108	20	good	good	ADJ
admet-373	108	21	correlation	correlation	NOUN
admet-373	108	22	to	to	ADP
admet-373	108	23	the	the	DET
admet-373	108	24	iam	iam	PROPN
admet-373	108	25	mb	mb	PROPN
admet-373	108	26	of	of	ADP
admet-373	108	27	drug	drug	NOUN
admet-373	108	28	discovery	discovery	NOUN
admet-373	108	29	compounds	compound	NOUN
admet-373	108	30	.	.	PUNCT
admet-373	109	1	the	the	DET
admet-373	109	2	iam	iam	PROPN
admet-373	109	3	mb	mb	PROPN
admet-373	109	4	data	datum	NOUN
admet-373	109	5	showed	show	VERB
admet-373	109	6	a	a	DET
admet-373	109	7	good	good	ADJ
admet-373	109	8	correlation	correlation	NOUN
admet-373	109	9	with	with	ADP
admet-373	109	10	the	the	DET
admet-373	109	11	intracellular	intracellular	ADJ
admet-373	109	12	concentration	concentration	NOUN
admet-373	109	13	of	of	ADP
admet-373	109	14	compounds	compound	NOUN
admet-373	109	15	,	,	PUNCT
admet-373	109	16	indicating	indicate	VERB
admet-373	109	17	that	that	SCONJ
admet-373	109	18	membrane	membrane	NOUN
admet-373	109	19	binding	binding	NOUN
admet-373	109	20	is	be	AUX
admet-373	109	21	important	important	ADJ
admet-373	109	22	to	to	PART
admet-373	109	23	get	get	VERB
admet-373	109	24	compounds	compound	NOUN
admet-373	109	25	into	into	ADP
admet-373	109	26	the	the	DET
admet-373	109	27	cell	cell	NOUN
admet-373	109	28	[	[	X
admet-373	109	29	48	48	NUM
admet-373	109	30	]	]	PUNCT
admet-373	109	31	.	.	PUNCT
admet-373	110	1	estimating	estimate	VERB
admet-373	110	2	the	the	DET
admet-373	110	3	potential	potential	ADJ
admet-373	110	4	clinical	clinical	ADJ
admet-373	110	5	dose	dose	NOUN
admet-373	110	6	as	as	ADV
admet-373	110	7	early	early	ADV
admet-373	110	8	as	as	ADP
admet-373	110	9	possible	possible	ADJ
admet-373	110	10	is	be	AUX
admet-373	110	11	an	an	DET
admet-373	110	12	important	important	ADJ
admet-373	110	13	aspect	aspect	NOUN
admet-373	110	14	of	of	ADP
admet-373	110	15	the	the	DET
admet-373	110	16	drug	drug	NOUN
admet-373	110	17	discovery	discovery	NOUN
admet-373	110	18	process	process	NOUN
admet-373	110	19	to	to	PART
admet-373	110	20	help	help	VERB
admet-373	110	21	select	select	VERB
admet-373	110	22	the	the	DET
admet-373	110	23	optimal	optimal	ADJ
admet-373	110	24	compound	compound	NOUN
admet-373	110	25	profile	profile	NOUN
admet-373	110	26	and	and	CCONJ
admet-373	110	27	highest	high	ADJ
admet-373	110	28	probability	probability	NOUN
admet-373	110	29	of	of	ADP
admet-373	110	30	successful	successful	ADJ
admet-373	110	31	progression	progression	NOUN
admet-373	110	32	to	to	ADP
admet-373	110	33	the	the	DET
admet-373	110	34	clinic	clinic	NOUN
admet-373	110	35	[	[	X
admet-373	110	36	49	49	NUM
admet-373	110	37	-	-	SYM
admet-373	110	38	50	50	NUM
admet-373	110	39	]	]	PUNCT
admet-373	110	40	.	.	PUNCT
admet-373	111	1	valko	valko	PROPN
admet-373	111	2	et	et	PROPN
admet-373	111	3	al	al	PROPN
admet-373	111	4	.	.	PUNCT
admet-373	112	1	[	[	X
admet-373	112	2	51	51	NUM
admet-373	112	3	]	]	PUNCT
admet-373	112	4	highlighted	highlight	VERB
admet-373	112	5	that	that	SCONJ
admet-373	112	6	the	the	DET
admet-373	112	7	maximum	maximum	ADJ
admet-373	112	8	achievable	achievable	ADJ
admet-373	112	9	drug	drug	NOUN
admet-373	112	10	efficiency	efficiency	NOUN
admet-373	112	11	(	(	PUNCT
admet-373	112	12	demax	demax	NOUN
admet-373	112	13	)	)	PUNCT
admet-373	112	14	that	that	PRON
admet-373	112	15	can	can	AUX
admet-373	112	16	be	be	AUX
admet-373	112	17	obtained	obtain	VERB
admet-373	112	18	assuming	assume	VERB
admet-373	112	19	(	(	PUNCT
admet-373	112	20	i	i	NOUN
admet-373	112	21	)	)	PUNCT
admet-373	112	22	100	100	NUM
admet-373	112	23	%	%	NOUN
admet-373	112	24	bioavailability	bioavailability	NOUN
admet-373	112	25	,	,	PUNCT
admet-373	112	26	(	(	PUNCT
admet-373	112	27	ii	ii	NOUN
admet-373	112	28	)	)	PUNCT
admet-373	112	29	no	no	DET
admet-373	112	30	permeability	permeability	NOUN
admet-373	112	31	barrier	barrier	NOUN
admet-373	112	32	and	and	CCONJ
admet-373	112	33	(	(	PUNCT
admet-373	112	34	iii	iii	NOUN
admet-373	112	35	)	)	PUNCT
admet-373	112	36	no	no	DET
admet-373	112	37	active	active	ADJ
admet-373	112	38	transport	transport	NOUN
admet-373	112	39	could	could	AUX
admet-373	112	40	be	be	AUX
admet-373	112	41	calculated	calculate	VERB
admet-373	112	42	using	use	VERB
admet-373	112	43	in	in	ADP
admet-373	112	44	vitro	vitro	X
admet-373	112	45	biomimetic	biomimetic	ADJ
admet-373	112	46	measurements	measurement	NOUN
admet-373	112	47	,	,	PUNCT
admet-373	112	48	essentially	essentially	ADV
admet-373	112	49	the	the	DET
admet-373	112	50	regis	regis	PROPN
admet-373	112	51	iam	iam	PROPN
admet-373	112	52	mb	mb	PROPN
admet-373	112	53	/	/	SYM
admet-373	112	54	pb	pb	ADP
admet-373	112	55	technology	technology	NOUN
admet-373	112	56	®	®	NOUN
admet-373	112	57	that	that	PRON
admet-373	112	58	we	we	PRON
admet-373	112	59	are	be	AUX
admet-373	112	60	proposing	propose	VERB
admet-373	112	61	in	in	ADP
admet-373	112	62	this	this	DET
admet-373	112	63	paper	paper	NOUN
admet-373	112	64	as	as	ADP
admet-373	112	65	a	a	DET
admet-373	112	66	useful	useful	ADJ
admet-373	112	67	tool	tool	NOUN
admet-373	112	68	in	in	ADP
admet-373	112	69	early	early	ADJ
admet-373	112	70	drug	drug	NOUN
admet-373	112	71	discovery	discovery	NOUN
admet-373	112	72	[	[	X
admet-373	112	73	51	51	NUM
admet-373	112	74	]	]	PUNCT
admet-373	112	75	.	.	PUNCT
admet-373	113	1	the	the	DET
admet-373	113	2	drug	drug	NOUN
admet-373	113	3	efficiency	efficiency	NOUN
admet-373	113	4	concept	concept	NOUN
admet-373	113	5	as	as	ADP
admet-373	113	6	a	a	DET
admet-373	113	7	design	design	NOUN
admet-373	113	8	parameter	parameter	NOUN
admet-373	113	9	has	have	VERB
admet-373	113	10	the	the	DET
admet-373	113	11	advantage	advantage	NOUN
admet-373	113	12	that	that	SCONJ
admet-373	113	13	it	it	PRON
admet-373	113	14	can	can	AUX
admet-373	113	15	be	be	AUX
admet-373	113	16	estimated	estimate	VERB
admet-373	113	17	from	from	ADP
admet-373	113	18	in	in	ADP
admet-373	113	19	vitro	vitro	X
admet-373	113	20	measurements	measurement	NOUN
admet-373	113	21	,	,	PUNCT
admet-373	113	22	and	and	CCONJ
admet-373	113	23	can	can	AUX
admet-373	113	24	be	be	AUX
admet-373	113	25	monitored	monitor	VERB
admet-373	113	26	during	during	ADP
admet-373	113	27	the	the	DET
admet-373	113	28	drug	drug	NOUN
admet-373	113	29	development	development	NOUN
admet-373	113	30	process	process	NOUN
admet-373	113	31	to	to	PART
admet-373	113	32	see	see	VERB
admet-373	113	33	how	how	SCONJ
admet-373	113	34	the	the	DET
admet-373	113	35	early	early	ADJ
admet-373	113	36	estimation	estimation	NOUN
admet-373	113	37	performs	perform	VERB
admet-373	113	38	when	when	SCONJ
admet-373	113	39	in	in	ADP
admet-373	113	40	vivo	vivo	ADJ
admet-373	113	41	measurements	measurement	NOUN
admet-373	113	42	become	become	VERB
admet-373	113	43	available	available	ADJ
admet-373	113	44	pre	pre	ADJ
admet-373	113	45	-	-	ADJ
admet-373	113	46	clinically	clinically	ADV
admet-373	113	47	,	,	PUNCT
admet-373	113	48	or	or	CCONJ
admet-373	113	49	from	from	ADP
admet-373	113	50	human	human	ADJ
admet-373	113	51	clinical	clinical	ADJ
admet-373	113	52	trials	trial	NOUN
admet-373	113	53	.	.	PUNCT
admet-373	114	1	in	in	ADP
admet-373	114	2	this	this	DET
admet-373	114	3	paper	paper	NOUN
admet-373	114	4	,	,	PUNCT
admet-373	114	5	the	the	DET
admet-373	114	6	intention	intention	NOUN
admet-373	114	7	is	be	AUX
admet-373	114	8	to	to	PART
admet-373	114	9	show	show	VERB
admet-373	114	10	the	the	DET
admet-373	114	11	models	model	NOUN
admet-373	114	12	and	and	CCONJ
admet-373	114	13	the	the	DET
admet-373	114	14	applicability	applicability	NOUN
admet-373	114	15	of	of	ADP
admet-373	114	16	the	the	DET
admet-373	114	17	regis	regis	PROPN
admet-373	114	18	iam	iam	PROPN
admet-373	114	19	mb	mb	PROPN
admet-373	114	20	/	/	SYM
admet-373	114	21	pb	pb	ADP
admet-373	114	22	technology	technology	NOUN
admet-373	114	23	®	®	NOUN
admet-373	114	24	in	in	ADP
admet-373	114	25	early	early	ADJ
admet-373	114	26	drug	drug	NOUN
admet-373	114	27	discovery	discovery	NOUN
admet-373	114	28	.	.	PUNCT
admet-373	115	1	it	it	PRON
admet-373	115	2	is	be	AUX
admet-373	115	3	also	also	ADV
admet-373	115	4	important	important	ADJ
admet-373	115	5	to	to	PART
admet-373	115	6	have	have	VERB
admet-373	115	7	the	the	DET
admet-373	115	8	ability	ability	NOUN
admet-373	115	9	to	to	PART
admet-373	115	10	estimate	estimate	VERB
admet-373	115	11	these	these	PRON
admet-373	115	12	in	in	ADP
admet-373	115	13	vitro	vitro	X
admet-373	115	14	properties	property	NOUN
admet-373	115	15	from	from	ADP
admet-373	115	16	the	the	DET
admet-373	115	17	chemical	chemical	NOUN
admet-373	115	18	structure	structure	NOUN
admet-373	115	19	thus	thus	ADV
admet-373	115	20	helping	help	VERB
admet-373	115	21	the	the	DET
admet-373	115	22	design	design	NOUN
admet-373	115	23	stage	stage	NOUN
admet-373	115	24	of	of	ADP
admet-373	115	25	the	the	DET
admet-373	115	26	molecules	molecule	NOUN
admet-373	115	27	too	too	ADV
admet-373	115	28	.	.	PUNCT
admet-373	116	1	it	it	PRON
admet-373	116	2	has	have	AUX
admet-373	116	3	been	be	AUX
admet-373	116	4	shown	show	VERB
admet-373	116	5	that	that	SCONJ
admet-373	116	6	the	the	DET
admet-373	116	7	retention	retention	NOUN
admet-373	116	8	of	of	ADP
admet-373	116	9	compounds	compound	NOUN
admet-373	116	10	obtained	obtain	VERB
admet-373	116	11	on	on	ADP
admet-373	116	12	the	the	DET
admet-373	116	13	proposed	propose	VERB
admet-373	116	14	biomimetic	biomimetic	ADJ
admet-373	116	15	stationary	stationary	ADJ
admet-373	116	16	phases	phase	NOUN
admet-373	116	17	can	can	AUX
admet-373	116	18	be	be	AUX
admet-373	116	19	estimated	estimate	VERB
admet-373	116	20	in	in	ADP
admet-373	116	21	silico	silico	NOUN
admet-373	116	22	[	[	X
admet-373	116	23	52	52	NUM
admet-373	116	24	-	-	SYM
admet-373	116	25	55	55	NUM
admet-373	116	26	]	]	PUNCT
admet-373	116	27	,	,	PUNCT
admet-373	116	28	however	however	ADV
admet-373	116	29	it	it	PRON
admet-373	116	30	is	be	AUX
admet-373	116	31	worth	worth	ADJ
admet-373	116	32	noting	note	VERB
admet-373	116	33	that	that	SCONJ
admet-373	116	34	the	the	DET
admet-373	116	35	in	in	ADP
admet-373	116	36	silico	silico	NOUN
admet-373	116	37	models	model	NOUN
admet-373	116	38	use	use	VERB
admet-373	116	39	2d	2d	NUM
admet-373	116	40	molecular	molecular	ADJ
admet-373	116	41	descriptors	descriptor	NOUN
admet-373	116	42	that	that	PRON
admet-373	116	43	are	be	AUX
admet-373	116	44	not	not	PART
admet-373	116	45	sufficient	sufficient	ADJ
admet-373	116	46	to	to	PART
admet-373	116	47	estimate	estimate	VERB
admet-373	116	48	the	the	DET
admet-373	116	49	3d	3d	PROPN
admet-373	116	50	contribution	contribution	NOUN
admet-373	116	51	of	of	ADP
admet-373	116	52	the	the	DET
admet-373	116	53	molecules	molecule	NOUN
admet-373	116	54	binding	bind	VERB
admet-373	116	55	to	to	ADP
admet-373	116	56	proteins	protein	NOUN
admet-373	116	57	,	,	PUNCT
admet-373	116	58	therefore	therefore	ADV
admet-373	116	59	they	they	PRON
admet-373	116	60	can	can	AUX
admet-373	116	61	be	be	AUX
admet-373	116	62	used	use	VERB
admet-373	116	63	only	only	ADV
admet-373	116	64	as	as	ADP
admet-373	116	65	a	a	DET
admet-373	116	66	rough	rough	ADJ
admet-373	116	67	estimations	estimation	NOUN
admet-373	116	68	.	.	PUNCT
admet-373	117	1	phospholipids	phospholipid	NOUN
admet-373	117	2	constitute	constitute	VERB
admet-373	117	3	approximately	approximately	ADV
admet-373	117	4	40	40	NUM
admet-373	117	5	%	%	NOUN
admet-373	117	6	of	of	ADP
admet-373	117	7	the	the	DET
admet-373	117	8	human	human	ADJ
admet-373	117	9	body	body	NOUN
admet-373	117	10	,	,	PUNCT
admet-373	117	11	therefore	therefore	ADV
admet-373	117	12	,	,	PUNCT
admet-373	117	13	the	the	DET
admet-373	117	14	phospholipid	phospholipid	NOUN
admet-373	117	15	binding	bind	VERB
admet-373	117	16	of	of	ADP
admet-373	117	17	compounds	compound	NOUN
admet-373	117	18	are	be	AUX
admet-373	117	19	a	a	DET
admet-373	117	20	very	very	ADV
admet-373	117	21	important	important	ADJ
admet-373	117	22	parameter	parameter	NOUN
admet-373	117	23	that	that	PRON
admet-373	117	24	should	should	AUX
admet-373	117	25	not	not	PART
admet-373	117	26	be	be	AUX
admet-373	117	27	ignored	ignore	VERB
admet-373	117	28	in	in	ADP
admet-373	117	29	the	the	DET
admet-373	117	30	drug	drug	NOUN
admet-373	117	31	design	design	NOUN
admet-373	117	32	process	process	NOUN
admet-373	117	33	.	.	PUNCT
admet-373	118	1	it	it	PRON
admet-373	118	2	was	be	AUX
admet-373	118	3	found	find	VERB
admet-373	118	4	that	that	SCONJ
admet-373	118	5	mb	mb	PROPN
admet-373	118	6	iam	iam	PROPN
admet-373	118	7	values	value	NOUN
admet-373	118	8	above	above	ADP
admet-373	118	9	50	50	NUM
admet-373	118	10	indicate	indicate	VERB
admet-373	118	11	promiscuous	promiscuous	ADJ
admet-373	118	12	binding	bind	VERB
admet-373	118	13	[	[	X
admet-373	118	14	57	57	NUM
admet-373	118	15	]	]	PUNCT
admet-373	118	16	,	,	PUNCT
admet-373	118	17	and	and	CCONJ
admet-373	119	1	higher	high	ADJ
admet-373	119	2	phospholipidotic	phospholipidotic	ADJ
admet-373	119	3	potential	potential	NOUN
admet-373	119	4	[	[	X
admet-373	119	5	56	56	NUM
admet-373	119	6	-	-	SYM
admet-373	119	7	59	59	NUM
admet-373	119	8	]	]	PUNCT
admet-373	119	9	for	for	ADP
admet-373	119	10	discovery	discovery	NOUN
admet-373	119	11	compound	compound	NOUN
admet-373	119	12	.	.	PUNCT
admet-373	120	1	it	it	PRON
admet-373	120	2	was	be	AUX
admet-373	120	3	also	also	ADV
admet-373	120	4	found	find	VERB
admet-373	120	5	that	that	SCONJ
admet-373	120	6	mb	mb	PROPN
admet-373	120	7	iam	iam	PROPN
admet-373	120	8	showed	show	VERB
admet-373	120	9	a	a	DET
admet-373	120	10	good	good	ADJ
admet-373	120	11	correlation	correlation	NOUN
admet-373	120	12	with	with	ADP
admet-373	120	13	the	the	DET
admet-373	120	14	total	total	ADJ
admet-373	120	15	cellular	cellular	ADJ
admet-373	120	16	concentration	concentration	NOUN
admet-373	120	17	of	of	ADP
admet-373	120	18	discovery	discovery	NOUN
admet-373	120	19	compounds	compound	NOUN
admet-373	120	20	[	[	X
admet-373	120	21	60	60	NUM
admet-373	120	22	]	]	PUNCT
admet-373	120	23	.	.	PUNCT
admet-373	121	1	in	in	ADP
admet-373	121	2	this	this	DET
admet-373	121	3	paper	paper	NOUN
admet-373	121	4	,	,	PUNCT
admet-373	121	5	we	we	PRON
admet-373	121	6	present	present	VERB
admet-373	121	7	the	the	DET
admet-373	121	8	models	model	NOUN
admet-373	121	9	for	for	ADP
admet-373	121	10	human	human	ADJ
admet-373	121	11	clinical	clinical	ADJ
admet-373	121	12	unbound	unbound	NOUN
admet-373	121	13	volume	volume	NOUN
admet-373	121	14	of	of	ADP
admet-373	121	15	distribution	distribution	NOUN
admet-373	121	16	and	and	CCONJ
admet-373	121	17	drug	drug	NOUN
admet-373	121	18	efficiency	efficiency	NOUN
admet-373	121	19	using	use	VERB
admet-373	121	20	measured	measure	VERB
admet-373	121	21	biomimetic	biomimetic	ADJ
admet-373	121	22	properties	property	NOUN
admet-373	121	23	,	,	PUNCT
admet-373	121	24	and	and	CCONJ
admet-373	121	25	we	we	PRON
admet-373	121	26	describe	describe	VERB
admet-373	121	27	a	a	DET
admet-373	121	28	protocol	protocol	NOUN
admet-373	121	29	how	how	SCONJ
admet-373	121	30	to	to	PART
admet-373	121	31	use	use	VERB
admet-373	121	32	these	these	DET
admet-373	121	33	data	datum	NOUN
admet-373	121	34	in	in	ADP
admet-373	121	35	early	early	ADJ
admet-373	121	36	lead	lead	ADJ
admet-373	121	37	optimisation	optimisation	NOUN
admet-373	121	38	.	.	PUNCT
admet-373	122	1	experimental	experimental	ADJ
admet-373	122	2	the	the	DET
admet-373	122	3	values	value	NOUN
admet-373	122	4	for	for	ADP
admet-373	122	5	dose	dose	NOUN
admet-373	122	6	,	,	PUNCT
admet-373	122	7	potency	potency	NOUN
admet-373	122	8	(	(	PUNCT
admet-373	122	9	pic50	pic50	NOUN
admet-373	122	10	)	)	PUNCT
admet-373	122	11	,	,	PUNCT
admet-373	122	12	the	the	DET
admet-373	122	13	volume	volume	NOUN
admet-373	122	14	of	of	ADP
admet-373	122	15	distribution	distribution	NOUN
admet-373	122	16	,	,	PUNCT
admet-373	122	17	clearance	clearance	NOUN
admet-373	122	18	,	,	PUNCT
admet-373	122	19	the	the	DET
admet-373	122	20	half	half	ADJ
admet-373	122	21	-	-	PUNCT
admet-373	122	22	life	life	NOUN
admet-373	122	23	of	of	ADP
admet-373	122	24	the	the	DET
admet-373	122	25	known	know	VERB
admet-373	122	26	drugs	drug	NOUN
admet-373	122	27	were	be	AUX
admet-373	122	28	obtained	obtain	VERB
admet-373	122	29	from	from	ADP
admet-373	122	30	various	various	ADJ
admet-373	122	31	databases	database	NOUN
admet-373	122	32	(	(	PUNCT
admet-373	122	33	www.drugbank.ca/drugs	www.drugbank.ca/drugs	PROPN
admet-373	122	34	and	and	CCONJ
admet-373	122	35	www.drugs.com	www.drugs.com	NUM
admet-373	122	36	)	)	PUNCT
admet-373	122	37	and	and	CCONJ
admet-373	122	38	listed	list	VERB
admet-373	122	39	in	in	ADP
admet-373	122	40	table	table	NOUN
admet-373	122	41	a1	a1	NOUN
admet-373	122	42	.	.	PUNCT
admet-373	123	1	the	the	DET
admet-373	123	2	measured	measure	VERB
admet-373	123	3	iam	iam	PROPN
admet-373	123	4	mb	mb	PROPN
admet-373	123	5	/	/	SYM
admet-373	123	6	pb	pb	NOUN
admet-373	123	7	data	datum	NOUN
admet-373	123	8	are	be	AUX
admet-373	123	9	published	publish	VERB
admet-373	123	10	in	in	ADP
admet-373	123	11	the	the	DET
admet-373	123	12	book	book	NOUN
admet-373	123	13	by	by	ADP
admet-373	123	14	valko	valko	NOUN
admet-373	124	1	[	[	X
admet-373	124	2	45	45	NUM
admet-373	124	3	]	]	PUNCT
admet-373	124	4	and	and	CCONJ
admet-373	124	5	listed	list	VERB
admet-373	124	6	in	in	ADP
admet-373	124	7	table	table	NOUN
admet-373	124	8	a2	a2	PROPN
admet-373	124	9	.	.	PUNCT
admet-373	124	10	table	table	NOUN
admet-373	124	11	a2	a2	PROPN
admet-373	124	12	contains	contain	VERB
admet-373	124	13	the	the	DET
admet-373	124	14	estimated	estimate	VERB
admet-373	124	15	volume	volume	NOUN
admet-373	124	16	of	of	ADP
admet-373	124	17	distribution	distribution	NOUN
admet-373	124	18	(	(	PUNCT
admet-373	124	19	iam	iam	PROPN
admet-373	124	20	mb	mb	PROPN
admet-373	124	21	/	/	SYM
admet-373	124	22	pb	pb	X
admet-373	124	23	log	log	NOUN
admet-373	124	24	vdss	vdss	ADV
admet-373	124	25	)	)	PUNCT
admet-373	124	26	and	and	CCONJ
admet-373	124	27	the	the	DET
admet-373	124	28	estimated	estimate	VERB
admet-373	124	29	unbound	unbound	NOUN
admet-373	124	30	http://www.drugbank.ca/drugs	http://www.drugbank.ca/drug	NOUN
admet-373	124	31	http://www.drugs.com/	http://www.drugs.com/	PROPN
admet-373	124	32	valko	valko	PROPN
admet-373	124	33	,	,	PUNCT
admet-373	124	34	teague	teague	NOUN
admet-373	124	35	and	and	CCONJ
admet-373	124	36	pidgeon	pidgeon	PROPN
admet-373	124	37	admet	admet	PROPN
admet-373	124	38	&	&	CCONJ
admet-373	124	39	dmpk	dmpk	PROPN
admet-373	124	40	5(1	5(1	NUM
admet-373	124	41	)	)	PUNCT
admet-373	124	42	(	(	PUNCT
admet-373	124	43	2017	2017	NUM
admet-373	124	44	)	)	PUNCT
admet-373	124	45	14	14	NUM
admet-373	124	46	-	-	SYM
admet-373	124	47	38	38	NUM
admet-373	124	48	20	20	NUM
admet-373	124	49	volume	volume	NOUN
admet-373	124	50	of	of	ADP
admet-373	124	51	distribution	distribution	NOUN
admet-373	124	52	(	(	PUNCT
admet-373	124	53	iam	iam	PROPN
admet-373	124	54	mb	mb	PROPN
admet-373	124	55	/	/	SYM
admet-373	124	56	pb	pb	X
admet-373	124	57	log	log	NOUN
admet-373	124	58	vdu	vdu	PROPN
admet-373	124	59	)	)	PUNCT
admet-373	124	60	using	use	VERB
admet-373	124	61	the	the	DET
admet-373	124	62	published	publish	VERB
admet-373	124	63	models	model	NOUN
admet-373	124	64	[	[	X
admet-373	124	65	42	42	NUM
admet-373	124	66	-	-	SYM
admet-373	124	67	43	43	NUM
admet-373	124	68	]	]	PUNCT
admet-373	124	69	,	,	PUNCT
admet-373	124	70	and	and	CCONJ
admet-373	124	71	the	the	DET
admet-373	124	72	regis	regis	PROPN
admet-373	124	73	iam	iam	PROPN
admet-373	124	74	mb	mb	PROPN
admet-373	124	75	/	/	SYM
admet-373	124	76	pb	pb	ADP
admet-373	124	77	technology	technology	NOUN
admet-373	124	78	®	®	PROPN
admet-373	124	79	.	.	PUNCT
admet-373	125	1	the	the	DET
admet-373	125	2	same	same	ADJ
admet-373	125	3	technology	technology	NOUN
admet-373	125	4	has	have	AUX
admet-373	125	5	been	be	AUX
admet-373	125	6	applied	apply	VERB
admet-373	125	7	to	to	PART
admet-373	125	8	estimate	estimate	VERB
admet-373	125	9	the	the	DET
admet-373	125	10	maximum	maximum	ADJ
admet-373	125	11	drug	drug	NOUN
admet-373	125	12	efficiency	efficiency	NOUN
admet-373	125	13	(	(	PUNCT
admet-373	125	14	hplc	hplc	NOUN
admet-373	125	15	demax	demax	NOUN
admet-373	125	16	)	)	PUNCT
admet-373	125	17	value	value	NOUN
admet-373	125	18	,	,	PUNCT
admet-373	125	19	that	that	PRON
admet-373	125	20	represents	represent	VERB
admet-373	125	21	the	the	DET
admet-373	125	22	maximum	maximum	ADJ
admet-373	125	23	drug	drug	NOUN
admet-373	125	24	efficiency	efficiency	NOUN
admet-373	125	25	that	that	PRON
admet-373	125	26	can	can	AUX
admet-373	125	27	be	be	AUX
admet-373	125	28	achieved	achieve	VERB
admet-373	125	29	when	when	SCONJ
admet-373	125	30	the	the	DET
admet-373	125	31	bioavailability	bioavailability	NOUN
admet-373	125	32	is	be	AUX
admet-373	125	33	100	100	NUM
admet-373	125	34	%	%	NOUN
admet-373	125	35	,	,	PUNCT
admet-373	125	36	and	and	CCONJ
admet-373	125	37	there	there	PRON
admet-373	125	38	is	be	VERB
admet-373	125	39	no	no	DET
admet-373	125	40	permeability	permeability	NOUN
admet-373	125	41	barrier	barrier	NOUN
admet-373	125	42	or	or	CCONJ
admet-373	125	43	active	active	ADJ
admet-373	125	44	transport	transport	NOUN
admet-373	125	45	to	to	PART
admet-373	125	46	disturb	disturb	VERB
admet-373	125	47	the	the	DET
admet-373	125	48	steady	steady	ADJ
admet-373	125	49	state	state	NOUN
admet-373	125	50	equilibrium	equilibrium	NOUN
admet-373	125	51	.	.	PUNCT
admet-373	126	1	this	this	PRON
admet-373	126	2	can	can	AUX
admet-373	126	3	be	be	AUX
admet-373	126	4	expressed	express	VERB
admet-373	126	5	as	as	ADP
admet-373	126	6	the	the	DET
admet-373	126	7	reciprocal	reciprocal	ADJ
admet-373	126	8	value	value	NOUN
admet-373	126	9	of	of	ADP
admet-373	126	10	the	the	DET
admet-373	126	11	steady	steady	ADJ
admet-373	126	12	-	-	PUNCT
admet-373	126	13	state	state	NOUN
admet-373	126	14	unbound	unbound	NOUN
admet-373	126	15	volume	volume	NOUN
admet-373	126	16	of	of	ADP
admet-373	126	17	distribution	distribution	NOUN
admet-373	126	18	[	[	X
admet-373	126	19	51	51	NUM
admet-373	126	20	]	]	PUNCT
admet-373	126	21	.	.	PUNCT
admet-373	127	1	the	the	DET
admet-373	127	2	iam	iam	PROPN
admet-373	127	3	mb	mb	PROPN
admet-373	127	4	data	datum	NOUN
admet-373	127	5	were	be	AUX
admet-373	127	6	obtained	obtain	VERB
admet-373	127	7	using	use	VERB
admet-373	127	8	iam	iam	PROPN
admet-373	127	9	pc.dd2	pc.dd2	PROPN
admet-373	127	10	hplc	hplc	NOUN
admet-373	127	11	column	column	NOUN
admet-373	127	12	(	(	PUNCT
admet-373	127	13	regis	regis	PROPN
admet-373	127	14	technologies	technologies	PROPN
admet-373	127	15	,	,	PUNCT
admet-373	127	16	inc	inc	PROPN
admet-373	127	17	.	.	PROPN
admet-373	127	18	,	,	PUNCT
admet-373	127	19	il	il	PROPN
admet-373	127	20	,	,	PUNCT
admet-373	127	21	usa	usa	PROPN
admet-373	127	22	)	)	PUNCT
admet-373	127	23	with	with	ADP
admet-373	127	24	the	the	DET
admet-373	127	25	dimensions	dimension	NOUN
admet-373	127	26	of	of	ADP
admet-373	127	27	100	100	NUM
admet-373	127	28	x	x	SYM
admet-373	127	29	3	3	NUM
admet-373	127	30	mm	mm	NOUN
admet-373	127	31	.	.	PUNCT
admet-373	128	1	mobile	mobile	ADJ
admet-373	128	2	phase	phase	NOUN
admet-373	128	3	a	a	PRON
admet-373	128	4	was	be	AUX
admet-373	128	5	50	50	NUM
admet-373	128	6	mm	mm	NOUN
admet-373	128	7	ammonium	ammonium	NOUN
admet-373	128	8	acetate	acetate	NOUN
admet-373	128	9	adjusted	adjust	VERB
admet-373	128	10	to	to	ADP
admet-373	128	11	ph	ph	PROPN
admet-373	128	12	7.4	7.4	NUM
admet-373	128	13	,	,	PUNCT
admet-373	128	14	while	while	SCONJ
admet-373	128	15	mobile	mobile	ADJ
admet-373	128	16	phase	phase	NOUN
admet-373	128	17	b	b	NOUN
admet-373	128	18	was	be	AUX
admet-373	128	19	100	100	NUM
admet-373	128	20	%	%	NOUN
admet-373	128	21	acetonitrile	acetonitrile	NOUN
admet-373	128	22	.	.	PUNCT
admet-373	129	1	the	the	DET
admet-373	129	2	flow	flow	NOUN
admet-373	129	3	rate	rate	NOUN
admet-373	129	4	was	be	AUX
admet-373	129	5	1.5	1.5	NUM
admet-373	129	6	ml/	ml/	NOUN
admet-373	129	7	min	min	PROPN
admet-373	129	8	,	,	PUNCT
admet-373	129	9	the	the	DET
admet-373	129	10	linear	linear	ADJ
admet-373	129	11	gradient	gradient	NOUN
admet-373	129	12	was	be	AUX
admet-373	129	13	0	0	NUM
admet-373	129	14	to	to	PART
admet-373	129	15	80	80	NUM
admet-373	129	16	%	%	NOUN
admet-373	129	17	acetonitrile	acetonitrile	NOUN
admet-373	129	18	in	in	ADP
admet-373	129	19	0	0	NUM
admet-373	129	20	to	to	PART
admet-373	129	21	5	5	NUM
admet-373	129	22	min	min	NOUN
admet-373	129	23	,	,	PUNCT
admet-373	129	24	5	5	NUM
admet-373	129	25	to	to	PART
admet-373	129	26	5.25	5.25	NUM
admet-373	129	27	min	min	NOUN
admet-373	129	28	80	80	NUM
admet-373	129	29	%	%	NOUN
admet-373	129	30	acetonitrile	acetonitrile	NOUN
admet-373	129	31	then	then	ADV
admet-373	129	32	back	back	ADV
admet-373	129	33	to	to	ADP
admet-373	129	34	0	0	NUM
admet-373	129	35	%	%	NOUN
admet-373	129	36	acetonitrile	acetonitrile	NOUN
admet-373	129	37	by	by	ADP
admet-373	129	38	5.5	5.5	NUM
admet-373	129	39	min	min	NOUN
admet-373	129	40	.	.	PUNCT
admet-373	130	1	the	the	DET
admet-373	130	2	total	total	ADJ
admet-373	130	3	run	run	NOUN
admet-373	130	4	time	time	NOUN
admet-373	130	5	is	be	AUX
admet-373	130	6	7	7	NUM
admet-373	130	7	min	min	NOUN
admet-373	130	8	.	.	PUNCT
admet-373	131	1	the	the	DET
admet-373	131	2	calibration	calibration	NOUN
admet-373	131	3	set	set	NOUN
admet-373	131	4	of	of	ADP
admet-373	131	5	compounds	compound	NOUN
admet-373	131	6	are	be	AUX
admet-373	131	7	listed	list	VERB
admet-373	131	8	in	in	ADP
admet-373	131	9	table	table	NOUN
admet-373	131	10	3	3	NUM
admet-373	131	11	and	and	CCONJ
admet-373	131	12	the	the	DET
admet-373	131	13	calibration	calibration	NOUN
admet-373	131	14	test	test	NOUN
admet-373	131	15	solution	solution	NOUN
admet-373	131	16	is	be	AUX
admet-373	131	17	available	available	ADJ
admet-373	131	18	from	from	ADP
admet-373	131	19	bio	bio	ADJ
admet-373	131	20	-	-	ADJ
admet-373	131	21	mimetic	mimetic	ADJ
admet-373	131	22	chromatography	chromatography	NOUN
admet-373	131	23	,	,	PUNCT
admet-373	131	24	uk	uk	PROPN
admet-373	131	25	(	(	PUNCT
admet-373	131	26	www.bio-mimetic-chromatography.com	www.bio-mimetic-chromatography.com	X
admet-373	131	27	)	)	PUNCT
admet-373	131	28	.	.	PUNCT
admet-373	132	1	a	a	DET
admet-373	132	2	typical	typical	ADJ
admet-373	132	3	chromatogram	chromatogram	NOUN
admet-373	132	4	is	be	AUX
admet-373	132	5	shown	show	VERB
admet-373	132	6	in	in	ADP
admet-373	132	7	figure	figure	NOUN
admet-373	132	8	2	2	NUM
admet-373	132	9	.	.	PUNCT
admet-373	133	1	it	it	PRON
admet-373	133	2	is	be	AUX
admet-373	133	3	essential	essential	ADJ
admet-373	133	4	to	to	PART
admet-373	133	5	obtain	obtain	VERB
admet-373	133	6	a	a	DET
admet-373	133	7	straight	straight	ADJ
admet-373	133	8	line	line	NOUN
admet-373	133	9	between	between	ADP
admet-373	133	10	the	the	DET
admet-373	133	11	retention	retention	NOUN
admet-373	133	12	times	time	NOUN
admet-373	133	13	and	and	CCONJ
admet-373	133	14	the	the	DET
admet-373	133	15	iam	iam	PROPN
admet-373	133	16	mb	mb	PROPN
admet-373	133	17	index	index	NOUN
admet-373	133	18	of	of	ADP
admet-373	133	19	the	the	DET
admet-373	133	20	calibration	calibration	NOUN
admet-373	133	21	set	set	NOUN
admet-373	133	22	of	of	ADP
admet-373	133	23	compounds	compound	NOUN
admet-373	133	24	.	.	PUNCT
admet-373	134	1	moreover	moreover	ADV
admet-373	134	2	,	,	PUNCT
admet-373	134	3	it	it	PRON
admet-373	134	4	is	be	AUX
admet-373	134	5	essential	essential	ADJ
admet-373	134	6	to	to	PART
admet-373	134	7	run	run	VERB
admet-373	134	8	a	a	DET
admet-373	134	9	system	system	NOUN
admet-373	134	10	suitability	suitability	NOUN
admet-373	134	11	test	test	NOUN
admet-373	134	12	of	of	ADP
admet-373	134	13	compounds	compound	NOUN
admet-373	134	14	(	(	PUNCT
admet-373	134	15	2	2	NUM
admet-373	134	16	neutral	neutral	ADJ
admet-373	134	17	,	,	PUNCT
admet-373	134	18	2	2	NUM
admet-373	134	19	basic	basic	ADJ
admet-373	134	20	and	and	CCONJ
admet-373	134	21	2	2	NUM
admet-373	134	22	acidic	acidic	ADJ
admet-373	134	23	compounds	compound	NOUN
admet-373	134	24	)	)	PUNCT
admet-373	134	25	listed	list	VERB
admet-373	134	26	in	in	ADP
admet-373	134	27	table	table	NOUN
admet-373	134	28	4	4	NUM
admet-373	134	29	,	,	PUNCT
admet-373	134	30	and	and	CCONJ
admet-373	134	31	check	check	VERB
admet-373	134	32	that	that	SCONJ
admet-373	134	33	the	the	DET
admet-373	134	34	measured	measured	ADJ
admet-373	134	35	iam	iam	PROPN
admet-373	134	36	mb	mb	PROPN
admet-373	134	37	data	datum	NOUN
admet-373	134	38	are	be	AUX
admet-373	134	39	the	the	DET
admet-373	134	40	same	same	ADJ
admet-373	134	41	+	+	NOUN
admet-373	134	42	/5	/5	NOUN
admet-373	134	43	units	unit	NOUN
admet-373	134	44	listed	list	VERB
admet-373	134	45	in	in	ADP
admet-373	134	46	the	the	DET
admet-373	134	47	table	table	NOUN
admet-373	134	48	.	.	PUNCT
admet-373	135	1	this	this	PRON
admet-373	135	2	ensures	ensure	VERB
admet-373	135	3	that	that	SCONJ
admet-373	135	4	the	the	DET
admet-373	135	5	iam	iam	PROPN
admet-373	135	6	phospholipid	phospholipid	NOUN
admet-373	135	7	immobilised	immobilise	VERB
admet-373	135	8	phase	phase	NOUN
admet-373	135	9	is	be	AUX
admet-373	135	10	maintained	maintain	VERB
admet-373	135	11	,	,	PUNCT
admet-373	135	12	preserving	preserve	VERB
admet-373	135	13	the	the	DET
admet-373	135	14	natural	natural	ADJ
admet-373	135	15	phospholipid	phospholipid	NOUN
admet-373	135	16	density	density	NOUN
admet-373	135	17	on	on	ADP
admet-373	135	18	the	the	DET
admet-373	135	19	column	column	NOUN
admet-373	135	20	.	.	PUNCT
admet-373	136	1	figure	figure	NOUN
admet-373	136	2	2	2	NUM
admet-373	136	3	.	.	PUNCT
admet-373	137	1	a	a	DET
admet-373	137	2	typical	typical	ADJ
admet-373	137	3	chromatogram	chromatogram	NOUN
admet-373	137	4	obtained	obtain	VERB
admet-373	137	5	on	on	ADP
admet-373	137	6	iam	iam	PROPN
admet-373	137	7	pc.dd2	pc.dd2	PROPN
admet-373	138	1	100	100	NUM
admet-373	138	2	x	x	SYM
admet-373	138	3	3	3	NUM
admet-373	138	4	mm	mm	PROPN
admet-373	138	5	hplc	hplc	NOUN
admet-373	138	6	column	column	NOUN
admet-373	138	7	.	.	PUNCT
admet-373	139	1	flow	flow	NOUN
admet-373	139	2	rate	rate	NOUN
admet-373	139	3	:	:	PUNCT
admet-373	139	4	1.5	1.5	NUM
admet-373	139	5	ml	ml	NOUN
admet-373	139	6	/	/	SYM
admet-373	139	7	min	min	NOUN
admet-373	139	8	,	,	PUNCT
admet-373	139	9	mobile	mobile	ADJ
admet-373	139	10	phase	phase	NOUN
admet-373	139	11	a	a	PRON
admet-373	139	12	;	;	PUNCT
admet-373	139	13	50	50	NUM
admet-373	139	14	mm	mm	NOUN
admet-373	139	15	ammonium	ammonium	NOUN
admet-373	139	16	acetate	acetate	NOUN
admet-373	139	17	adjusted	adjust	VERB
admet-373	139	18	to	to	ADP
admet-373	139	19	ph	ph	PROPN
admet-373	139	20	7.4	7.4	NUM
admet-373	139	21	,	,	PUNCT
admet-373	139	22	b	b	NOUN
admet-373	139	23	:	:	PUNCT
admet-373	139	24	acetonitrile	acetonitrile	ADJ
admet-373	139	25	.	.	PUNCT
admet-373	140	1	run	run	VERB
admet-373	140	2	time	time	NOUN
admet-373	140	3	7	7	NUM
admet-373	140	4	min	min	NOUN
admet-373	140	5	;	;	PUNCT
admet-373	140	6	gradient	gradient	NOUN
admet-373	140	7	:	:	PUNCT
admet-373	140	8	0	0	NUM
admet-373	140	9	to	to	PART
admet-373	140	10	5	5	NUM
admet-373	140	11	min	min	NOUN
admet-373	140	12	0	0	NUM
admet-373	140	13	to	to	ADP
admet-373	140	14	80	80	NUM
admet-373	140	15	%	%	NOUN
admet-373	140	16	b	b	NOUN
admet-373	140	17	,	,	PUNCT
admet-373	140	18	5	5	NUM
admet-373	140	19	to	to	PART
admet-373	140	20	5.25	5.25	NUM
admet-373	140	21	min	min	NOUN
admet-373	140	22	80	80	NUM
admet-373	140	23	%	%	NOUN
admet-373	140	24	b	b	NOUN
admet-373	140	25	,	,	PUNCT
admet-373	140	26	5.25	5.25	NUM
admet-373	140	27	to	to	ADP
admet-373	140	28	5.5	5.5	NUM
admet-373	140	29	min	min	NOUN
admet-373	141	1	0	0	NUM
admet-373	141	2	%	%	NOUN
admet-373	141	3	b	b	NOUN
admet-373	142	1	it	it	PRON
admet-373	142	2	was	be	AUX
admet-373	142	3	found	find	VERB
admet-373	142	4	that	that	SCONJ
admet-373	142	5	the	the	DET
admet-373	142	6	log	log	NOUN
admet-373	142	7	k(iam	k(iam	PROPN
admet-373	142	8	)	)	PUNCT
admet-373	142	9	shows	show	VERB
admet-373	142	10	a	a	DET
admet-373	142	11	non	non	ADJ
admet-373	142	12	-	-	ADJ
admet-373	142	13	linear	linear	ADJ
admet-373	142	14	relationship	relationship	NOUN
admet-373	142	15	with	with	ADP
admet-373	142	16	log	log	NOUN
admet-373	142	17	p	p	NOUN
admet-373	142	18	octanol	octanol	NOUN
admet-373	142	19	/	/	SYM
admet-373	142	20	water	water	NOUN
admet-373	142	21	values	value	NOUN
admet-373	142	22	[	[	X
admet-373	142	23	42	42	NUM
admet-373	142	24	]	]	PUNCT
admet-373	142	25	.	.	PUNCT
admet-373	143	1	to	to	PART
admet-373	143	2	convert	convert	VERB
admet-373	143	3	the	the	DET
admet-373	143	4	log	log	NOUN
admet-373	143	5	k(iam	k(iam	PROPN
admet-373	143	6	)	)	PUNCT
admet-373	143	7	scale	scale	NOUN
admet-373	143	8	to	to	ADP
admet-373	143	9	the	the	DET
admet-373	143	10	log	log	NOUN
admet-373	143	11	p	p	NOUN
admet-373	143	12	scale	scale	NOUN
admet-373	143	13	we	we	PRON
admet-373	143	14	need	need	VERB
admet-373	143	15	the	the	DET
admet-373	143	16	transformation	transformation	NOUN
admet-373	143	17	as	as	SCONJ
admet-373	143	18	shown	show	VERB
admet-373	143	19	by	by	ADP
admet-373	143	20	equation	equation	NOUN
admet-373	143	21	(	(	PUNCT
admet-373	143	22	1	1	NUM
admet-373	143	23	)	)	PUNCT
admet-373	143	24	.	.	PUNCT
admet-373	144	1	the	the	DET
admet-373	144	2	converted	convert	VERB
admet-373	144	3	log	log	NOUN
admet-373	144	4	k(iam	k(iam	PROPN
admet-373	144	5	)	)	PUNCT
admet-373	144	6	data	datum	NOUN
admet-373	144	7	is	be	AUX
admet-373	144	8	equivalent	equivalent	ADJ
admet-373	144	9	to	to	ADP
admet-373	144	10	the	the	DET
admet-373	144	11	partition	partition	NOUN
admet-373	144	12	coefficient	coefficient	NOUN
admet-373	144	13	of	of	ADP
admet-373	144	14	the	the	DET
admet-373	144	15	compound	compound	NOUN
admet-373	144	16	between	between	ADP
admet-373	144	17	the	the	DET
admet-373	144	18	ph	ph	ADJ
admet-373	144	19	7.4	7.4	NUM
admet-373	144	20	buffer	buffer	NOUN
admet-373	144	21	and	and	CCONJ
admet-373	144	22	the	the	DET
admet-373	144	23	phospholipid	phospholipid	NOUN
admet-373	144	24	phase	phase	NOUN
admet-373	144	25	.	.	PUNCT
admet-373	145	1	log	log	VERB
admet-373	145	2	k(iam)=	k(iam)=	PROPN
admet-373	145	3	0.29	0.29	NUM
admet-373	145	4	*	*	SYM
admet-373	145	5	e(0.046*mb	e(0.046*mb	ADP
admet-373	145	6	iam+0.42	iam+0.42	PROPN
admet-373	145	7	)	)	PUNCT
admet-373	145	8	+	+	CCONJ
admet-373	145	9	0.70	0.70	NUM
admet-373	145	10	(	(	PUNCT
admet-373	145	11	1	1	NUM
admet-373	145	12	)	)	PUNCT
admet-373	145	13	this	this	DET
admet-373	145	14	data	datum	NOUN
admet-373	145	15	are	be	AUX
admet-373	145	16	then	then	ADV
admet-373	145	17	be	be	AUX
admet-373	145	18	used	use	VERB
admet-373	145	19	in	in	ADP
admet-373	145	20	the	the	DET
admet-373	145	21	models	model	NOUN
admet-373	145	22	for	for	ADP
admet-373	145	23	the	the	DET
admet-373	145	24	volume	volume	NOUN
admet-373	145	25	of	of	ADP
admet-373	145	26	distribution	distribution	NOUN
admet-373	145	27	,	,	PUNCT
admet-373	145	28	unbound	unbound	NOUN
admet-373	145	29	volume	volume	NOUN
admet-373	145	30	of	of	ADP
admet-373	145	31	distribution	distribution	NOUN
admet-373	145	32	and	and	CCONJ
admet-373	145	33	the	the	DET
admet-373	145	34	in	in	ADV
admet-373	145	35	vitro	vitro	X
admet-373	145	36	maximum	maximum	ADJ
admet-373	145	37	drug	drug	NOUN
admet-373	145	38	efficiency	efficiency	NOUN
admet-373	145	39	(	(	PUNCT
admet-373	145	40	hplc	hplc	NOUN
admet-373	145	41	demax	demax	PROPN
admet-373	145	42	)	)	PUNCT
admet-373	145	43	.	.	PUNCT
admet-373	146	1	http://www.bio-mimetic-chromatography.com/	http://www.bio-mimetic-chromatography.com/	PROPN
admet-373	146	2	admet	admet	PROPN
admet-373	146	3	&	&	CCONJ
admet-373	146	4	dmpk	dmpk	PROPN
admet-373	146	5	5(1	5(1	NUM
admet-373	146	6	)	)	PUNCT
admet-373	146	7	(	(	PUNCT
admet-373	146	8	2017	2017	NUM
admet-373	146	9	)	)	PUNCT
admet-373	146	10	14	14	NUM
admet-373	146	11	-	-	SYM
admet-373	146	12	38	38	NUM
admet-373	146	13	in	in	ADP
admet-373	146	14	vitro	vitro	X
admet-373	146	15	membrane	membrane	NOUN
admet-373	146	16	and	and	CCONJ
admet-373	146	17	protein	protein	NOUN
admet-373	146	18	binding	bind	VERB
admet-373	146	19	doi	doi	NOUN
admet-373	146	20	:	:	PUNCT
admet-373	146	21	10.5599	10.5599	NUM
admet-373	146	22	/	/	SYM
admet-373	146	23	admet.5.1.373	admet.5.1.373	ADP
admet-373	146	24	21	21	NUM
admet-373	146	25	table	table	NOUN
admet-373	146	26	3	3	NUM
admet-373	146	27	.	.	PUNCT
admet-373	147	1	the	the	DET
admet-373	147	2	calibration	calibration	NOUN
admet-373	147	3	set	set	NOUN
admet-373	147	4	of	of	ADP
admet-373	147	5	compounds	compound	NOUN
admet-373	147	6	and	and	CCONJ
admet-373	147	7	their	their	PRON
admet-373	147	8	standard	standard	ADJ
admet-373	147	9	iam	iam	PROPN
admet-373	147	10	mb	mb	ADP
admet-373	147	11	score	score	NOUN
admet-373	147	12	on	on	ADP
admet-373	147	13	iam.pc.dd2	iam.pc.dd2	PROPN
admet-373	147	14	column	column	PROPN
admet-373	147	15	.	.	PUNCT
admet-373	148	1	the	the	DET
admet-373	148	2	iam	iam	PROPN
admet-373	148	3	mb	mb	PROPN
admet-373	148	4	data	data	PROPN
admet-373	148	5	approximate	approximate	VERB
admet-373	148	6	to	to	ADP
admet-373	148	7	the	the	DET
admet-373	148	8	acetonitrile	acetonitrile	ADJ
admet-373	148	9	concentration	concentration	NOUN
admet-373	148	10	in	in	ADP
admet-373	148	11	the	the	DET
admet-373	148	12	mobile	mobile	ADJ
admet-373	148	13	phase	phase	NOUN
admet-373	148	14	when	when	SCONJ
admet-373	148	15	the	the	DET
admet-373	148	16	compound	compound	NOUN
admet-373	148	17	elutes	elute	NOUN
admet-373	148	18	using	use	VERB
admet-373	148	19	the	the	DET
admet-373	148	20	gradient	gradient	ADJ
admet-373	148	21	conditions	condition	NOUN
admet-373	148	22	.	.	PUNCT
admet-373	149	1	the	the	DET
admet-373	149	2	log	log	PROPN
admet-373	149	3	k(iam	k(iam	PROPN
admet-373	149	4	)	)	PUNCT
admet-373	149	5	values	value	NOUN
admet-373	149	6	obtained	obtain	VERB
admet-373	149	7	as	as	ADP
admet-373	149	8	0.046iam	0.046iam	PROPN
admet-373	149	9	mb+0.42	mb+0.42	ADP
admet-373	149	10	where	where	SCONJ
admet-373	149	11	the	the	DET
admet-373	149	12	constants	constant	NOUN
admet-373	149	13	have	have	AUX
admet-373	149	14	been	be	AUX
admet-373	149	15	derived	derive	VERB
admet-373	149	16	by	by	ADP
admet-373	149	17	plotting	plot	VERB
admet-373	149	18	isocratic	isocratic	ADJ
admet-373	149	19	log	log	NOUN
admet-373	149	20	k(iam	k(iam	PROPN
admet-373	149	21	)	)	PUNCT
admet-373	149	22	data	datum	NOUN
admet-373	149	23	extrapolated	extrapolate	VERB
admet-373	149	24	to	to	ADP
admet-373	149	25	0	0	NUM
admet-373	149	26	%	%	NOUN
admet-373	149	27	acetonitrile	acetonitrile	ADJ
admet-373	149	28	mobile	mobile	ADJ
admet-373	149	29	phase	phase	NOUN
admet-373	149	30	using	use	VERB
admet-373	149	31	isocratic	isocratic	ADJ
admet-373	149	32	measurements	measurement	NOUN
admet-373	149	33	[	[	X
admet-373	149	34	52	52	NUM
admet-373	149	35	]	]	PUNCT
admet-373	149	36	.	.	PUNCT
admet-373	150	1	compound	compound	NOUN
admet-373	150	2	typical	typical	ADJ
admet-373	150	3	tr	tr	PRON
admet-373	150	4	(	(	PUNCT
admet-373	150	5	min	min	NOUN
admet-373	150	6	)	)	PUNCT
admet-373	150	7	iam	iam	PROPN
admet-373	151	1	mb	mb	AUX
admet-373	151	2	log	log	PROPN
admet-373	151	3	k(iam	k(iam	PROPN
admet-373	151	4	)	)	PUNCT
admet-373	151	5	octanophenone	octanophenone	VERB
admet-373	151	6	3.18	3.18	NUM
admet-373	151	7	49.4	49.4	NUM
admet-373	151	8	2.69	2.69	NUM
admet-373	151	9	heptanophenone	heptanophenone	NOUN
admet-373	151	10	3.07	3.07	NUM
admet-373	151	11	45.7	45.7	NUM
admet-373	151	12	2.52	2.52	NUM
admet-373	151	13	hexanophenone	hexanophenone	NOUN
admet-373	151	14	2.94	2.94	NUM
admet-373	151	15	41.8	41.8	NUM
admet-373	151	16	2.34	2.34	NUM
admet-373	151	17	valerophenone	valerophenone	NOUN
admet-373	151	18	2.79	2.79	NUM
admet-373	151	19	37.3	37.3	NUM
admet-373	151	20	2.14	2.14	NUM
admet-373	151	21	butyrophenone	butyrophenone	NOUN
admet-373	151	22	2.58	2.58	NUM
admet-373	151	23	32	32	NUM
admet-373	151	24	1.89	1.89	NUM
admet-373	151	25	propiophenone	propiophenone	NOUN
admet-373	151	26	2.35	2.35	NUM
admet-373	151	27	25.9	25.9	NUM
admet-373	151	28	1.61	1.61	NUM
admet-373	151	29	acetophenone	acetophenone	NOUN
admet-373	151	30	2.04	2.04	NUM
admet-373	151	31	17.2	17.2	NUM
admet-373	151	32	1.21	1.21	NUM
admet-373	151	33	acetanilide	acetanilide	ADV
admet-373	151	34	1.85	1.85	NUM
admet-373	151	35	11.5	11.5	NUM
admet-373	151	36	0.95	0.95	NUM
admet-373	151	37	paracetamol	paracetamol	NOUN
admet-373	151	38	1.62	1.62	NUM
admet-373	151	39	2.9	2.9	NUM
admet-373	151	40	0.55	0.55	NUM
admet-373	151	41	table	table	NOUN
admet-373	151	42	4	4	NUM
admet-373	151	43	.	.	PUNCT
admet-373	151	44	system	system	NOUN
admet-373	151	45	suitability	suitability	NOUN
admet-373	151	46	test	test	NOUN
admet-373	151	47	compounds	compound	NOUN
admet-373	151	48	and	and	CCONJ
admet-373	151	49	their	their	PRON
admet-373	151	50	expected	expect	VERB
admet-373	151	51	iam	iam	PROPN
admet-373	151	52	mb	mb	PROPN
admet-373	151	53	data	data	PROPN
admet-373	151	54	.	.	PUNCT
admet-373	152	1	the	the	DET
admet-373	152	2	measured	measured	ADJ
admet-373	152	3	values	value	NOUN
admet-373	152	4	should	should	AUX
admet-373	152	5	be	be	AUX
admet-373	152	6	within	within	ADP
admet-373	152	7	5	5	NUM
admet-373	152	8	iam	iam	PROPN
admet-373	152	9	mb	mb	ADP
admet-373	152	10	value	value	NOUN
admet-373	152	11	agreements	agreement	NOUN
admet-373	152	12	with	with	ADP
admet-373	152	13	the	the	DET
admet-373	152	14	values	value	NOUN
admet-373	152	15	in	in	ADP
admet-373	152	16	the	the	DET
admet-373	152	17	table	table	NOUN
admet-373	152	18	.	.	PUNCT
admet-373	153	1	further	further	ADJ
admet-373	153	2	drug	drug	NOUN
admet-373	153	3	molecules	molecule	NOUN
admet-373	153	4	data	datum	NOUN
admet-373	153	5	can	can	AUX
admet-373	153	6	be	be	AUX
admet-373	153	7	found	find	VERB
admet-373	153	8	in	in	ADP
admet-373	153	9	reference	reference	NOUN
admet-373	153	10	[	[	X
admet-373	153	11	45	45	NUM
admet-373	153	12	]	]	PUNCT
admet-373	153	13	.	.	PUNCT
admet-373	154	1	compound	compound	NOUN
admet-373	154	2	acid	acid	NOUN
admet-373	154	3	/	/	SYM
admet-373	154	4	base	base	NOUN
admet-373	154	5	iam	iam	PROPN
admet-373	154	6	mb	mb	ADP
admet-373	154	7	carbamazepine	carbamazepine	PROPN
admet-373	154	8	neutral	neutral	ADJ
admet-373	154	9	26.5	26.5	NUM
admet-373	154	10	colchicine	colchicine	PROPN
admet-373	154	11	neutral	neutral	ADJ
admet-373	154	12	18.0	18.0	NUM
admet-373	154	13	warfarin	warfarin	NOUN
admet-373	154	14	acidic	acidic	ADJ
admet-373	154	15	16.0	16.0	NUM
admet-373	154	16	indomethacin	indomethacin	NOUN
admet-373	154	17	acidic	acidic	ADJ
admet-373	154	18	24.5	24.5	NUM
admet-373	154	19	nicardipine	nicardipine	NOUN
admet-373	154	20	basic	basic	ADJ
admet-373	154	21	45.1	45.1	NUM
admet-373	154	22	propranolol	propranolol	NOUN
admet-373	154	23	basic	basic	ADJ
admet-373	154	24	46.8	46.8	NUM
admet-373	154	25	the	the	PRON
admet-373	154	26	pb	pb	ADP
admet-373	154	27	data	datum	NOUN
admet-373	154	28	are	be	AUX
admet-373	154	29	obtained	obtain	VERB
admet-373	154	30	on	on	ADP
admet-373	154	31	chiralpack	chiralpack	NOUN
admet-373	154	32	-	-	PUNCT
admet-373	154	33	hsa	hsa	NOUN
admet-373	154	34	and	and	CCONJ
admet-373	154	35	chiralpack	chiralpack	VERB
admet-373	154	36	agp	agp	NOUN
admet-373	154	37	columns	column	NOUN
admet-373	154	38	with	with	ADP
admet-373	154	39	the	the	DET
admet-373	154	40	dimensions	dimension	NOUN
admet-373	154	41	of	of	ADP
admet-373	154	42	50	50	NUM
admet-373	154	43	x	x	SYM
admet-373	154	44	3	3	NUM
admet-373	154	45	mm	mm	NOUN
admet-373	154	46	.	.	PUNCT
admet-373	155	1	the	the	DET
admet-373	155	2	flow	flow	NOUN
admet-373	155	3	rate	rate	NOUN
admet-373	155	4	was	be	AUX
admet-373	155	5	1.5	1.5	NUM
admet-373	155	6	ml	ml	NOUN
admet-373	155	7	/	/	SYM
admet-373	155	8	min	min	NOUN
admet-373	155	9	and	and	CCONJ
admet-373	155	10	2	2	NUM
admet-373	155	11	-	-	PUNCT
admet-373	155	12	propanol	propanol	NOUN
admet-373	155	13	was	be	AUX
admet-373	155	14	used	use	VERB
admet-373	155	15	as	as	ADP
admet-373	155	16	mobile	mobile	ADJ
admet-373	155	17	phase	phase	NOUN
admet-373	155	18	b	b	NOUN
admet-373	155	19	,	,	PUNCT
admet-373	155	20	while	while	SCONJ
admet-373	155	21	mobile	mobile	ADJ
admet-373	155	22	phase	phase	NOUN
admet-373	155	23	a	a	PRON
admet-373	155	24	is	be	AUX
admet-373	155	25	50	50	NUM
admet-373	155	26	mm	mm	NOUN
admet-373	155	27	ammonium	ammonium	NOUN
admet-373	155	28	acetate	acetate	NOUN
admet-373	155	29	adjusted	adjust	VERB
admet-373	155	30	ph	ph	PROPN
admet-373	155	31	to	to	ADP
admet-373	155	32	7.4	7.4	NUM
admet-373	155	33	.	.	PUNCT
admet-373	156	1	the	the	DET
admet-373	156	2	calibration	calibration	NOUN
admet-373	156	3	set	set	NOUN
admet-373	156	4	of	of	ADP
admet-373	156	5	compounds	compound	NOUN
admet-373	156	6	and	and	CCONJ
admet-373	156	7	their	their	PRON
admet-373	156	8	log	log	NOUN
admet-373	156	9	k(hsa	k(hsa	NOUN
admet-373	156	10	)	)	PUNCT
admet-373	156	11	and	and	CCONJ
admet-373	156	12	log	log	VERB
admet-373	156	13	k(agp	k(agp	PROPN
admet-373	156	14	)	)	PUNCT
admet-373	156	15	data	datum	NOUN
admet-373	156	16	are	be	AUX
admet-373	156	17	listed	list	VERB
admet-373	156	18	in	in	ADP
admet-373	156	19	table	table	NOUN
admet-373	156	20	5a	5a	NUM
admet-373	156	21	and	and	CCONJ
admet-373	156	22	5b	5b	NUM
admet-373	156	23	.	.	PUNCT
admet-373	157	1	these	these	DET
admet-373	157	2	data	datum	NOUN
admet-373	157	3	are	be	AUX
admet-373	157	4	derived	derive	VERB
admet-373	157	5	from	from	ADP
admet-373	157	6	literature	literature	NOUN
admet-373	157	7	%	%	NOUN
admet-373	157	8	hsa	hsa	NOUN
admet-373	157	9	and	and	CCONJ
admet-373	157	10	%	%	INTJ
admet-373	157	11	agp	agp	NOUN
admet-373	157	12	binding	bind	VERB
admet-373	157	13	data	datum	NOUN
admet-373	157	14	obtained	obtain	VERB
admet-373	157	15	by	by	ADP
admet-373	157	16	other	other	ADJ
admet-373	157	17	methodology	methodology	NOUN
admet-373	157	18	(	(	PUNCT
admet-373	157	19	equilibrium	equilibrium	NOUN
admet-373	157	20	dialysis	dialysis	NOUN
admet-373	157	21	and	and	CCONJ
admet-373	157	22	ultrafiltration	ultrafiltration	NOUN
admet-373	157	23	)	)	PUNCT
admet-373	157	24	.	.	PUNCT
admet-373	158	1	these	these	DET
admet-373	158	2	data	datum	NOUN
admet-373	158	3	are	be	AUX
admet-373	158	4	used	use	VERB
admet-373	158	5	to	to	PART
admet-373	158	6	calibrate	calibrate	VERB
admet-373	158	7	the	the	DET
admet-373	158	8	gradient	gradient	ADJ
admet-373	158	9	retention	retention	NOUN
admet-373	158	10	times	time	NOUN
admet-373	158	11	on	on	ADP
admet-373	158	12	the	the	DET
admet-373	158	13	protein	protein	NOUN
admet-373	158	14	column	column	NOUN
admet-373	158	15	so	so	SCONJ
admet-373	158	16	that	that	SCONJ
admet-373	158	17	the	the	DET
admet-373	158	18	binding	bind	VERB
admet-373	158	19	data	datum	NOUN
admet-373	158	20	obtained	obtain	VERB
admet-373	158	21	from	from	ADP
admet-373	158	22	the	the	DET
admet-373	158	23	retention	retention	NOUN
admet-373	158	24	times	time	NOUN
admet-373	158	25	are	be	AUX
admet-373	158	26	comparable	comparable	ADJ
admet-373	158	27	with	with	ADP
admet-373	158	28	binding	bind	VERB
admet-373	158	29	data	datum	NOUN
admet-373	158	30	obtained	obtain	VERB
admet-373	158	31	by	by	ADP
admet-373	158	32	other	other	ADJ
admet-373	158	33	methodologies	methodology	NOUN
admet-373	158	34	.	.	PUNCT
admet-373	159	1	the	the	DET
admet-373	159	2	typical	typical	ADJ
admet-373	159	3	retention	retention	NOUN
admet-373	159	4	times	time	NOUN
admet-373	159	5	were	be	AUX
admet-373	159	6	obtained	obtain	VERB
admet-373	159	7	using	use	VERB
admet-373	159	8	a	a	DET
admet-373	159	9	6	6	NUM
admet-373	159	10	min	min	NOUN
admet-373	159	11	gradient	gradient	NOUN
admet-373	159	12	run	run	NOUN
admet-373	159	13	:	:	PUNCT
admet-373	159	14	0	0	NUM
admet-373	159	15	to	to	PART
admet-373	159	16	3	3	NUM
admet-373	159	17	min	min	NOUN
admet-373	159	18	0	0	NUM
admet-373	159	19	to	to	PART
admet-373	159	20	35	35	NUM
admet-373	159	21	%	%	NOUN
admet-373	159	22	2	2	NUM
admet-373	159	23	-	-	PUNCT
admet-373	159	24	propanol	propanol	NOUN
admet-373	159	25	,	,	PUNCT
admet-373	159	26	3	3	NUM
admet-373	159	27	to	to	PART
admet-373	159	28	4	4	NUM
admet-373	159	29	min	min	NOUN
admet-373	159	30	35	35	NUM
admet-373	159	31	%	%	NOUN
admet-373	159	32	2propanol	2propanol	NUM
admet-373	159	33	,	,	PUNCT
admet-373	159	34	4	4	NUM
admet-373	159	35	to	to	PART
admet-373	159	36	4.2	4.2	NUM
admet-373	159	37	min	min	NOUN
admet-373	159	38	back	back	ADV
admet-373	159	39	to	to	ADP
admet-373	159	40	0	0	NUM
admet-373	159	41	%	%	NOUN
admet-373	159	42	2	2	NUM
admet-373	159	43	-	-	PUNCT
admet-373	159	44	propanol	propanol	NOUN
admet-373	159	45	.	.	PUNCT
admet-373	160	1	typical	typical	ADJ
admet-373	160	2	calibration	calibration	NOUN
admet-373	160	3	plots	plot	NOUN
admet-373	160	4	and	and	CCONJ
admet-373	160	5	chromatograms	chromatogram	NOUN
admet-373	160	6	have	have	AUX
admet-373	160	7	been	be	AUX
admet-373	160	8	published	publish	VERB
admet-373	160	9	previously	previously	ADV
admet-373	160	10	[	[	X
admet-373	160	11	14	14	NUM
admet-373	160	12	]	]	PUNCT
admet-373	160	13	.	.	PUNCT
admet-373	161	1	it	it	PRON
admet-373	161	2	was	be	AUX
admet-373	161	3	found	find	VERB
admet-373	161	4	that	that	SCONJ
admet-373	161	5	the	the	DET
admet-373	161	6	obtained	obtain	VERB
admet-373	161	7	log	log	NOUN
admet-373	161	8	k(hsa	k(hsa	NOUN
admet-373	161	9	)	)	PUNCT
admet-373	161	10	showed	show	VERB
admet-373	161	11	a	a	DET
admet-373	161	12	non	non	ADJ
admet-373	161	13	-	-	ADJ
admet-373	161	14	linear	linear	ADJ
admet-373	161	15	relationship	relationship	NOUN
admet-373	161	16	with	with	ADP
admet-373	161	17	the	the	DET
admet-373	161	18	log	log	NOUN
admet-373	161	19	p	p	NOUN
admet-373	161	20	values	value	NOUN
admet-373	161	21	of	of	ADP
admet-373	161	22	acetophenone	acetophenone	NOUN
admet-373	161	23	homologues	homologue	NOUN
admet-373	161	24	[	[	X
admet-373	161	25	42	42	NUM
admet-373	161	26	]	]	PUNCT
admet-373	161	27	.	.	PUNCT
admet-373	162	1	to	to	PART
admet-373	162	2	convert	convert	VERB
admet-373	162	3	the	the	DET
admet-373	162	4	log	log	NOUN
admet-373	162	5	k(hsa	k(hsa	NOUN
admet-373	162	6	)	)	PUNCT
admet-373	162	7	data	datum	NOUN
admet-373	162	8	to	to	ADP
admet-373	162	9	the	the	DET
admet-373	162	10	log	log	NOUN
admet-373	162	11	p	p	NOUN
admet-373	162	12	scale	scale	NOUN
admet-373	162	13	we	we	PRON
admet-373	162	14	need	need	VERB
admet-373	162	15	to	to	PART
admet-373	162	16	transform	transform	VERB
admet-373	162	17	them	they	PRON
admet-373	162	18	using	use	VERB
admet-373	162	19	equation	equation	NOUN
admet-373	162	20	2	2	NUM
admet-373	162	21	.	.	PUNCT
admet-373	163	1	the	the	DET
admet-373	163	2	so	so	ADV
admet-373	163	3	obtained	obtain	VERB
admet-373	163	4	log	log	PROPN
admet-373	163	5	k(hsa	k(hsa	NOUN
admet-373	163	6	)	)	PUNCT
admet-373	163	7	data	datum	NOUN
admet-373	163	8	are	be	AUX
admet-373	163	9	used	use	VERB
admet-373	163	10	in	in	ADP
admet-373	163	11	the	the	DET
admet-373	163	12	models	model	NOUN
admet-373	163	13	.	.	PUNCT
admet-373	164	1	log	log	VERB
admet-373	164	2	k(hsa	k(hsa	NOUN
admet-373	164	3	)	)	PUNCT
admet-373	164	4	=	=	SYM
admet-373	164	5	elog	elog	NOUN
admet-373	164	6	k(hsa	k(hsa	PROPN
admet-373	164	7	)	)	PUNCT
admet-373	164	8	(	(	PUNCT
admet-373	164	9	2	2	X
admet-373	164	10	)	)	PUNCT
admet-373	164	11	the	the	DET
admet-373	164	12	published	publish	VERB
admet-373	164	13	in	in	ADP
admet-373	164	14	vivo	vivo	NOUN
admet-373	164	15	models	model	NOUN
admet-373	164	16	used	use	VERB
admet-373	164	17	the	the	DET
admet-373	164	18	above	above	ADV
admet-373	164	19	-	-	PUNCT
admet-373	164	20	described	describe	VERB
admet-373	164	21	mb	mb	NOUN
admet-373	164	22	/	/	SYM
admet-373	164	23	pb	pb	ADP
admet-373	164	24	data	datum	NOUN
admet-373	164	25	using	use	VERB
admet-373	164	26	the	the	DET
admet-373	164	27	following	follow	VERB
admet-373	164	28	equations	equation	NOUN
admet-373	164	29	below	below	ADV
admet-373	164	30	:	:	PUNCT
admet-373	164	31	mb	mb	X
admet-373	164	32	/	/	SYM
admet-373	164	33	pb	pb	NOUN
admet-373	164	34	log	log	NOUN
admet-373	164	35	vdss=	vdss=	NUM
admet-373	164	36	0.44*log	0.44*log	PROPN
admet-373	164	37	k(iam)-0.22*log	k(iam)-0.22*log	PROPN
admet-373	164	38	k(hsa	k(hsa	PROPN
admet-373	164	39	)	)	PUNCT
admet-373	164	40	0.66	0.66	NUM
admet-373	164	41	(	(	PUNCT
admet-373	164	42	3	3	NUM
admet-373	164	43	)	)	PUNCT
admet-373	164	44	n=179	n=179	PROPN
admet-373	164	45	r2=0.76	r2=0.76	PROPN
admet-373	164	46	s=0.33	s=0.33	PROPN
admet-373	164	47	valko	valko	PROPN
admet-373	164	48	,	,	PUNCT
admet-373	164	49	teague	teague	NOUN
admet-373	164	50	and	and	CCONJ
admet-373	164	51	pidgeon	pidgeon	PROPN
admet-373	164	52	admet	admet	PROPN
admet-373	164	53	&	&	CCONJ
admet-373	164	54	dmpk	dmpk	PROPN
admet-373	164	55	5(1	5(1	NUM
admet-373	164	56	)	)	PUNCT
admet-373	164	57	(	(	PUNCT
admet-373	164	58	2017	2017	NUM
admet-373	164	59	)	)	PUNCT
admet-373	164	60	14	14	NUM
admet-373	164	61	-	-	SYM
admet-373	164	62	38	38	NUM
admet-373	164	63	22	22	NUM
admet-373	164	64	where	where	SCONJ
admet-373	164	65	mb	mb	NOUN
admet-373	164	66	/	/	SYM
admet-373	164	67	pb	pb	X
admet-373	164	68	log	log	NOUN
admet-373	164	69	vdss	vdss	ADV
admet-373	164	70	is	be	AUX
admet-373	164	71	the	the	DET
admet-373	164	72	estimated	estimate	VERB
admet-373	164	73	in	in	ADP
admet-373	164	74	vivo	vivo	ADJ
admet-373	164	75	steady	steady	ADJ
admet-373	164	76	state	state	NOUN
admet-373	164	77	volume	volume	NOUN
admet-373	164	78	of	of	ADP
admet-373	164	79	distribution	distribution	NOUN
admet-373	164	80	based	base	VERB
admet-373	164	81	on	on	ADP
admet-373	164	82	179	179	NUM
admet-373	164	83	known	know	VERB
admet-373	164	84	drugs	drug	NOUN
admet-373	164	85	human	human	ADJ
admet-373	164	86	clinical	clinical	ADJ
admet-373	164	87	data	datum	NOUN
admet-373	165	1	[	[	X
admet-373	165	2	42	42	NUM
admet-373	165	3	]	]	PUNCT
admet-373	165	4	.	.	PUNCT
admet-373	166	1	the	the	DET
admet-373	166	2	model	model	NOUN
admet-373	166	3	for	for	ADP
admet-373	166	4	the	the	DET
admet-373	166	5	unbound	unbound	NOUN
admet-373	166	6	volume	volume	NOUN
admet-373	166	7	of	of	ADP
admet-373	166	8	distribution	distribution	NOUN
admet-373	166	9	has	have	AUX
admet-373	166	10	also	also	ADV
admet-373	166	11	been	be	AUX
admet-373	166	12	published	publish	VERB
admet-373	166	13	previously	previously	ADV
admet-373	166	14	using	use	VERB
admet-373	166	15	the	the	DET
admet-373	166	16	available	available	ADJ
admet-373	166	17	data	datum	NOUN
admet-373	166	18	for	for	ADP
admet-373	166	19	70	70	NUM
admet-373	166	20	marketed	market	VERB
admet-373	166	21	drugs	drug	NOUN
admet-373	166	22	[	[	X
admet-373	166	23	43	43	NUM
admet-373	166	24	]	]	PUNCT
admet-373	166	25	and	and	CCONJ
admet-373	166	26	shown	show	VERB
admet-373	166	27	by	by	ADP
admet-373	166	28	equation	equation	NOUN
admet-373	166	29	4	4	NUM
admet-373	166	30	.	.	PUNCT
admet-373	167	1	mb	mb	NOUN
admet-373	167	2	/	/	SYM
admet-373	167	3	pb	pb	X
admet-373	167	4	log	log	NOUN
admet-373	167	5	vdu	vdu	PROPN
admet-373	167	6	=	=	PROPN
admet-373	167	7	0.23	0.23	NUM
admet-373	167	8	log	log	NOUN
admet-373	167	9	k(hsa	k(hsa	PROPN
admet-373	167	10	)	)	PUNCT
admet-373	167	11	+	+	NUM
admet-373	167	12	0.43	0.43	NUM
admet-373	167	13	log	log	NOUN
admet-373	167	14	k(iam	k(iam	PROPN
admet-373	167	15	)	)	PUNCT
admet-373	167	16	0.72	0.72	NUM
admet-373	167	17	(	(	PUNCT
admet-373	167	18	4	4	NUM
admet-373	167	19	)	)	PUNCT
admet-373	167	20	n=70	n=70	ADJ
admet-373	167	21	r2=	r2=	PROPN
admet-373	167	22	0.84	0.84	NUM
admet-373	167	23	s=0.32	s=0.32	ADP
admet-373	167	24	the	the	DET
admet-373	167	25	hplc	hplc	NOUN
admet-373	167	26	demax	demax	NOUN
admet-373	167	27	data	datum	NOUN
admet-373	167	28	were	be	AUX
admet-373	167	29	calculated	calculate	VERB
admet-373	167	30	using	use	VERB
admet-373	167	31	the	the	DET
admet-373	167	32	reciprocal	reciprocal	ADJ
admet-373	167	33	value	value	NOUN
admet-373	167	34	of	of	ADP
admet-373	167	35	the	the	DET
admet-373	167	36	mb	mb	NOUN
admet-373	167	37	/	/	SYM
admet-373	167	38	pb	pb	NOUN
admet-373	167	39	log	log	NOUN
admet-373	167	40	vdu	vdu	PROPN
admet-373	167	41	data	datum	NOUN
admet-373	167	42	and	and	CCONJ
admet-373	167	43	validated	validate	VERB
admet-373	167	44	against	against	ADP
admet-373	167	45	human	human	ADJ
admet-373	167	46	clinical	clinical	ADJ
admet-373	167	47	demax	demax	NOUN
admet-373	167	48	data	datum	NOUN
admet-373	168	1	[	[	X
admet-373	168	2	51	51	NUM
admet-373	168	3	]	]	PUNCT
admet-373	168	4	.	.	PUNCT
admet-373	169	1	table	table	NOUN
admet-373	169	2	5	5	NUM
admet-373	169	3	.	.	PUNCT
admet-373	170	1	the	the	DET
admet-373	170	2	literature	literature	NOUN
admet-373	170	3	%	%	NOUN
admet-373	170	4	binding	bind	VERB
admet-373	170	5	data	datum	NOUN
admet-373	170	6	and	and	CCONJ
admet-373	170	7	the	the	DET
admet-373	170	8	log	log	NOUN
admet-373	170	9	k(hsa	k(hsa	PROPN
admet-373	170	10	)	)	PUNCT
admet-373	170	11	(	(	PUNCT
admet-373	170	12	a	a	X
admet-373	170	13	)	)	PUNCT
admet-373	170	14	and	and	CCONJ
admet-373	170	15	log	log	VERB
admet-373	170	16	k(agp	k(agp	PROPN
admet-373	170	17	)	)	PUNCT
admet-373	170	18	(	(	PUNCT
admet-373	170	19	b	b	X
admet-373	170	20	)	)	PUNCT
admet-373	170	21	data	datum	NOUN
admet-373	170	22	for	for	ADP
admet-373	170	23	the	the	DET
admet-373	170	24	calibration	calibration	NOUN
admet-373	170	25	set	set	NOUN
admet-373	170	26	of	of	ADP
admet-373	170	27	compounds	compound	NOUN
admet-373	170	28	.	.	PUNCT
admet-373	171	1	the	the	DET
admet-373	171	2	logarithmic	logarithmic	ADJ
admet-373	171	3	retention	retention	NOUN
admet-373	171	4	times	time	NOUN
admet-373	171	5	measured	measure	VERB
admet-373	171	6	under	under	ADP
admet-373	171	7	a	a	DET
admet-373	171	8	given	give	VERB
admet-373	171	9	condition	condition	NOUN
admet-373	171	10	should	should	AUX
admet-373	171	11	result	result	VERB
admet-373	171	12	in	in	ADP
admet-373	171	13	a	a	DET
admet-373	171	14	straight	straight	ADJ
admet-373	171	15	line	line	NOUN
admet-373	171	16	when	when	SCONJ
admet-373	171	17	plotted	plot	VERB
admet-373	171	18	against	against	ADP
admet-373	171	19	the	the	DET
admet-373	171	20	log	log	NOUN
admet-373	171	21	k	k	PROPN
admet-373	171	22	data	data	PROPN
admet-373	171	23	.	.	PUNCT
admet-373	172	1	the	the	DET
admet-373	172	2	regression	regression	NOUN
admet-373	172	3	coefficient	coefficient	NOUN
admet-373	172	4	should	should	AUX
admet-373	172	5	be	be	AUX
admet-373	172	6	above	above	ADP
admet-373	172	7	0.96	0.96	NUM
admet-373	172	8	and	and	CCONJ
admet-373	172	9	the	the	DET
admet-373	172	10	warfarin	warfarin	NOUN
admet-373	172	11	enantiomers	enantiomer	NOUN
admet-373	172	12	should	should	AUX
admet-373	172	13	be	be	AUX
admet-373	172	14	baseline	baseline	VERB
admet-373	172	15	separated	separate	VERB
admet-373	172	16	in	in	ADP
admet-373	172	17	order	order	NOUN
admet-373	172	18	to	to	PART
admet-373	172	19	pass	pass	VERB
admet-373	172	20	the	the	DET
admet-373	172	21	suitability	suitability	NOUN
admet-373	172	22	of	of	ADP
admet-373	172	23	the	the	DET
admet-373	172	24	column	column	NOUN
admet-373	172	25	for	for	ADP
admet-373	172	26	protein	protein	NOUN
admet-373	172	27	binding	bind	VERB
admet-373	172	28	determination	determination	NOUN
admet-373	172	29	.	.	PUNCT
admet-373	173	1	(	(	PUNCT
admet-373	173	2	a	a	X
admet-373	173	3	)	)	PUNCT
admet-373	173	4	bio	bio	ADJ
admet-373	173	5	-	-	ADJ
admet-373	173	6	mimetic	mimetic	ADJ
admet-373	173	7	chromatography	chromatography	NOUN
admet-373	173	8	calibration	calibration	NOUN
admet-373	173	9	set	set	NOUN
admet-373	173	10	of	of	ADP
admet-373	173	11	compounds	compound	NOUN
admet-373	173	12	typical	typical	ADJ
admet-373	173	13	tr	tr	NOUN
admet-373	173	14	(	(	PUNCT
admet-373	173	15	min	min	NOUN
admet-373	173	16	)	)	PUNCT
admet-373	173	17	log	log	NOUN
admet-373	173	18	tr	tr	NOUN
admet-373	173	19	%	%	NOUN
admet-373	173	20	hsa	hsa	NOUN
admet-373	173	21	from	from	ADP
admet-373	173	22	literature	literature	NOUN
admet-373	173	23	plasma	plasma	NOUN
admet-373	173	24	protein	protein	NOUN
admet-373	173	25	binding	bind	VERB
admet-373	173	26	log	log	NOUN
admet-373	173	27	k(hsa	k(hsa	NOUN
admet-373	173	28	)	)	PUNCT
admet-373	173	29	(	(	PUNCT
admet-373	173	30	as	as	ADP
admet-373	173	31	log(%hsa/(101%hsa	log(%hsa/(101%hsa	NOUN
admet-373	173	32	)	)	PUNCT
admet-373	173	33	)	)	PUNCT
admet-373	173	34	warfarin	warfarin	NOUN
admet-373	173	35	3.267	3.267	NUM
admet-373	173	36	0.51	0.51	NUM
admet-373	173	37	97.90	97.90	NUM
admet-373	173	38	1.50	1.50	NUM
admet-373	173	39	paracetamol	paracetamol	NOUN
admet-373	173	40	0.285	0.285	NUM
admet-373	173	41	-0.55	-0.55	NUM
admet-373	173	42	14.00	14.00	NUM
admet-373	173	43	-0.79	-0.79	NOUN
admet-373	173	44	nizatidine	nizatidine	NOUN
admet-373	173	45	0.293	0.293	NUM
admet-373	173	46	-0.53	-0.53	NUM
admet-373	173	47	20.40	20.40	NUM
admet-373	173	48	-0.60	-0.60	NUM
admet-373	173	49	trimethoprim	trimethoprim	VERB
admet-373	173	50	0.512	0.512	DET
admet-373	173	51	-0.29	-0.29	NOUN
admet-373	173	52	37.60	37.60	NUM
admet-373	173	53	-0.23	-0.23	NUM
admet-373	173	54	propranolol	propranolol	PROPN
admet-373	173	55	0.895	0.895	NUM
admet-373	173	56	-0.05	-0.05	NUM
admet-373	173	57	66.60	66.60	NUM
admet-373	173	58	0.29	0.29	NUM
admet-373	173	59	carbamazepine	carbamazepine	NOUN
admet-373	173	60	1.216	1.216	NUM
admet-373	173	61	0.08	0.08	NUM
admet-373	173	62	75.00	75.00	NUM
admet-373	173	63	0.46	0.46	NUM
admet-373	173	64	nicardipine	nicardipine	NOUN
admet-373	173	65	2.374	2.374	NUM
admet-373	173	66	0.38	0.38	NUM
admet-373	173	67	95.00	95.00	NUM
admet-373	173	68	1.20	1.20	NUM
admet-373	173	69	indomethacin	indomethacin	VERB
admet-373	173	70	4.117	4.117	NUM
admet-373	173	71	0.61	0.61	NUM
admet-373	173	72	99.50	99.50	NUM
admet-373	173	73	1.82	1.82	NUM
admet-373	173	74	diclofenac	diclofenac	NOUN
admet-373	173	75	3.879	3.879	NUM
admet-373	173	76	0.59	0.59	NUM
admet-373	173	77	99.80	99.80	NUM
admet-373	173	78	1.92	1.92	NUM
admet-373	173	79	(	(	PUNCT
admet-373	173	80	b	b	NOUN
admet-373	173	81	)	)	PUNCT
admet-373	173	82	bio	bio	ADJ
admet-373	173	83	-	-	ADJ
admet-373	173	84	mimetic	mimetic	ADJ
admet-373	173	85	chromatography	chromatography	NOUN
admet-373	173	86	calibration	calibration	NOUN
admet-373	173	87	set	set	NOUN
admet-373	173	88	of	of	ADP
admet-373	173	89	compounds	compound	NOUN
admet-373	173	90	typical	typical	ADJ
admet-373	173	91	tr	tr	PUNCT
admet-373	173	92	min	min	NOUN
admet-373	173	93	log	log	NOUN
admet-373	173	94	tr	tr	NOUN
admet-373	173	95	%	%	NOUN
admet-373	173	96	agp	agp	NOUN
admet-373	173	97	(	(	PUNCT
admet-373	173	98	obtained	obtain	VERB
admet-373	173	99	by	by	ADP
admet-373	173	100	ultrafiltration	ultrafiltration	NOUN
admet-373	173	101	[	[	X
admet-373	173	102	45	45	NUM
admet-373	173	103	]	]	PUNCT
admet-373	173	104	)	)	PUNCT
admet-373	173	105	log	log	PROPN
admet-373	173	106	k(agp	k(agp	PROPN
admet-373	173	107	)	)	PUNCT
admet-373	173	108	(	(	PUNCT
admet-373	173	109	expressed	express	VERB
admet-373	173	110	from	from	ADP
admet-373	173	111	%	%	INTJ
admet-373	173	112	agp	agp	PROPN
admet-373	173	113	as	as	ADP
admet-373	173	114	log	log	NOUN
admet-373	173	115	(	(	PUNCT
admet-373	173	116	%	%	NOUN
admet-373	173	117	agp/(101-%agp	agp/(101-%agp	ADJ
admet-373	173	118	)	)	PUNCT
admet-373	173	119	)	)	PUNCT
admet-373	173	120	warfarin	warfarin	NOUN
admet-373	173	121	3.72	3.72	NUM
admet-373	173	122	0.57	0.57	NUM
admet-373	173	123	83.2	83.2	NUM
admet-373	173	124	0.67	0.67	NUM
admet-373	173	125	acetaminophen	acetaminophen	NOUN
admet-373	173	126	1.16	1.16	NUM
admet-373	173	127	0.06	0.06	NUM
admet-373	173	128	3.2	3.2	NUM
admet-373	173	129	-1.49	-1.49	NOUN
admet-373	173	130	nizatidine	nizatidine	NOUN
admet-373	173	131	2.19	2.19	NUM
admet-373	173	132	0.34	0.34	NUM
admet-373	173	133	37.1	37.1	NUM
admet-373	173	134	-0.24	-0.24	NOUN
admet-373	173	135	trimethoprim	trimethoprim	NOUN
admet-373	173	136	2.50	2.50	NUM
admet-373	173	137	0.40	0.40	NUM
admet-373	173	138	46.2	46.2	NUM
admet-373	173	139	-0.07	-0.07	NUM
admet-373	173	140	propranolol	propranolol	PROPN
admet-373	173	141	3.86	3.86	NUM
admet-373	173	142	0.59	0.59	NUM
admet-373	173	143	86	86	NUM
admet-373	173	144	0.76	0.76	NUM
admet-373	173	145	carbamazepine	carbamazepine	NOUN
admet-373	173	146	3.21	3.21	NUM
admet-373	173	147	0.51	0.51	NUM
admet-373	173	148	73.2	73.2	NUM
admet-373	173	149	0.42	0.42	NUM
admet-373	173	150	nicardipine	nicardipine	NOUN
admet-373	173	151	4.08	4.08	NUM
admet-373	173	152	0.61	0.61	NUM
admet-373	173	153	92	92	NUM
admet-373	173	154	1.01	1.01	NUM
admet-373	173	155	indomethacin	indomethacin	VERB
admet-373	173	156	2.98	2.98	NUM
admet-373	173	157	0.47	0.47	NUM
admet-373	173	158	52.9	52.9	NUM
admet-373	173	159	0.04	0.04	NUM
admet-373	173	160	diclofenac	diclofenac	NOUN
admet-373	173	161	3.09	3.09	NUM
admet-373	173	162	0.49	0.49	NUM
admet-373	173	163	69.3	69.3	NUM
admet-373	173	164	0.34	0.34	NUM
admet-373	173	165	for	for	ADP
admet-373	173	166	the	the	DET
admet-373	173	167	calculation	calculation	NOUN
admet-373	173	168	of	of	ADP
admet-373	173	169	the	the	DET
admet-373	173	170	stepwise	stepwise	PROPN
admet-373	173	171	regression	regression	NOUN
admet-373	173	172	equations	equation	NOUN
admet-373	173	173	,	,	PUNCT
admet-373	173	174	the	the	DET
admet-373	173	175	academic	academic	ADJ
admet-373	173	176	version	version	NOUN
admet-373	173	177	of	of	ADP
admet-373	173	178	jmp	jmp	PROPN
admet-373	173	179	(	(	PUNCT
admet-373	173	180	sas	sas	PROPN
admet-373	173	181	institute	institute	PROPN
admet-373	173	182	)	)	PUNCT
admet-373	173	183	software	software	NOUN
admet-373	173	184	has	have	AUX
admet-373	173	185	been	be	AUX
admet-373	173	186	used	use	VERB
admet-373	173	187	.	.	PUNCT
admet-373	174	1	the	the	DET
admet-373	174	2	calculation	calculation	NOUN
admet-373	174	3	of	of	ADP
admet-373	174	4	the	the	DET
admet-373	174	5	physicochemical	physicochemical	ADJ
admet-373	174	6	parameters	parameter	NOUN
admet-373	174	7	the	the	DET
admet-373	174	8	chemaxon	chemaxon	NOUN
admet-373	174	9	and	and	CCONJ
admet-373	174	10	acd	acd	NOUN
admet-373	174	11	software	software	NOUN
admet-373	174	12	were	be	AUX
admet-373	174	13	used	use	VERB
admet-373	174	14	.	.	PUNCT
admet-373	175	1	for	for	ADP
admet-373	175	2	creating	create	VERB
admet-373	175	3	the	the	DET
admet-373	175	4	plots	plot	NOUN
admet-373	175	5	the	the	DET
admet-373	175	6	sentira	sentira	PROPN
admet-373	175	7	version	version	PROPN
admet-373	175	8	1.0.0.6	1.0.0.6	NUM
admet-373	175	9	(	(	PUNCT
admet-373	175	10	optibrium	optibrium	NOUN
admet-373	175	11	2014	2014	NUM
admet-373	175	12	)	)	PUNCT
admet-373	175	13	software	software	NOUN
admet-373	175	14	has	have	AUX
admet-373	175	15	been	be	AUX
admet-373	175	16	used	use	VERB
admet-373	175	17	.	.	PUNCT
admet-373	176	1	admet	admet	PROPN
admet-373	176	2	&	&	CCONJ
admet-373	176	3	dmpk	dmpk	PROPN
admet-373	176	4	5(1	5(1	NUM
admet-373	176	5	)	)	PUNCT
admet-373	176	6	(	(	PUNCT
admet-373	176	7	2017	2017	NUM
admet-373	176	8	)	)	PUNCT
admet-373	176	9	14	14	NUM
admet-373	176	10	-	-	SYM
admet-373	176	11	38	38	NUM
admet-373	176	12	in	in	ADP
admet-373	176	13	vitro	vitro	X
admet-373	176	14	membrane	membrane	NOUN
admet-373	176	15	and	and	CCONJ
admet-373	176	16	protein	protein	NOUN
admet-373	176	17	binding	bind	VERB
admet-373	176	18	doi	doi	NOUN
admet-373	176	19	:	:	PUNCT
admet-373	176	20	10.5599	10.5599	NUM
admet-373	176	21	/	/	SYM
admet-373	176	22	admet.5.1.373	admet.5.1.373	ADP
admet-373	176	23	23	23	NUM
admet-373	176	24	results	result	NOUN
admet-373	176	25	and	and	CCONJ
admet-373	176	26	discussion	discussion	VERB
admet-373	176	27	the	the	DET
admet-373	176	28	importance	importance	NOUN
admet-373	176	29	of	of	ADP
admet-373	176	30	the	the	DET
admet-373	176	31	unbound	unbound	NOUN
admet-373	176	32	volume	volume	NOUN
admet-373	176	33	of	of	ADP
admet-373	176	34	distribution	distribution	NOUN
admet-373	176	35	and	and	CCONJ
admet-373	176	36	the	the	DET
admet-373	176	37	drug	drug	NOUN
admet-373	176	38	efficiency	efficiency	NOUN
admet-373	176	39	in	in	ADP
admet-373	176	40	the	the	DET
admet-373	176	41	drug	drug	NOUN
admet-373	176	42	discovery	discovery	NOUN
admet-373	176	43	process	process	NOUN
admet-373	176	44	has	have	AUX
admet-373	176	45	been	be	AUX
admet-373	176	46	discussed	discuss	VERB
admet-373	176	47	in	in	ADP
admet-373	176	48	several	several	ADJ
admet-373	176	49	recent	recent	ADJ
admet-373	176	50	papers	paper	NOUN
admet-373	176	51	focusing	focus	VERB
admet-373	176	52	on	on	ADP
admet-373	176	53	the	the	DET
admet-373	176	54	clearance	clearance	NOUN
admet-373	176	55	and	and	CCONJ
admet-373	176	56	plasma	plasma	NOUN
admet-373	176	57	protein	protein	NOUN
admet-373	176	58	binding	bind	VERB
admet-373	176	59	[	[	PUNCT
admet-373	176	60	15	15	NUM
admet-373	176	61	-	-	SYM
admet-373	176	62	16	16	NUM
admet-373	176	63	]	]	PUNCT
admet-373	176	64	.	.	PUNCT
admet-373	177	1	there	there	PRON
admet-373	177	2	is	be	VERB
admet-373	177	3	a	a	DET
admet-373	177	4	general	general	ADJ
admet-373	177	5	consensus	consensus	NOUN
admet-373	177	6	that	that	SCONJ
admet-373	177	7	the	the	DET
admet-373	177	8	free	free	ADJ
admet-373	177	9	concentration	concentration	NOUN
admet-373	177	10	of	of	ADP
admet-373	177	11	the	the	DET
admet-373	177	12	compound	compound	NOUN
admet-373	177	13	at	at	ADP
admet-373	177	14	the	the	DET
admet-373	177	15	site	site	NOUN
admet-373	177	16	of	of	ADP
admet-373	177	17	action	action	NOUN
admet-373	177	18	drives	drive	VERB
admet-373	177	19	clinical	clinical	ADJ
admet-373	177	20	efficacy	efficacy	NOUN
admet-373	177	21	together	together	ADV
admet-373	177	22	with	with	ADP
admet-373	177	23	the	the	DET
admet-373	177	24	high	high	ADJ
admet-373	177	25	affinity	affinity	NOUN
admet-373	177	26	for	for	ADP
admet-373	177	27	the	the	DET
admet-373	177	28	target	target	NOUN
admet-373	177	29	receptor	receptor	NOUN
admet-373	177	30	.	.	PUNCT
admet-373	178	1	however	however	ADV
admet-373	178	2	,	,	PUNCT
admet-373	178	3	a	a	DET
admet-373	178	4	significant	significant	ADJ
admet-373	178	5	debate	debate	NOUN
admet-373	178	6	remains	remain	VERB
admet-373	178	7	regarding	regard	VERB
admet-373	178	8	what	what	PRON
admet-373	178	9	determines	determine	VERB
admet-373	178	10	the	the	DET
admet-373	178	11	free	free	ADJ
admet-373	178	12	concentration	concentration	NOUN
admet-373	178	13	;	;	PUNCT
admet-373	178	14	the	the	DET
admet-373	178	15	dose	dose	NOUN
admet-373	178	16	,	,	PUNCT
admet-373	178	17	dosing	dosing	ADJ
admet-373	178	18	frequency	frequency	NOUN
admet-373	178	19	,	,	PUNCT
admet-373	178	20	intrinsic	intrinsic	ADJ
admet-373	178	21	clearance	clearance	NOUN
admet-373	178	22	,	,	PUNCT
admet-373	178	23	plasma	plasma	NOUN
admet-373	178	24	protein	protein	NOUN
admet-373	178	25	binding	bind	VERB
admet-373	178	26	or	or	CCONJ
admet-373	178	27	volume	volume	NOUN
admet-373	178	28	of	of	ADP
admet-373	178	29	distribution	distribution	NOUN
admet-373	178	30	,	,	PUNCT
admet-373	178	31	all	all	PRON
admet-373	178	32	are	be	AUX
admet-373	178	33	important	important	ADJ
admet-373	178	34	factors	factor	NOUN
admet-373	178	35	that	that	PRON
admet-373	178	36	should	should	AUX
admet-373	178	37	be	be	AUX
admet-373	178	38	considered	consider	VERB
admet-373	178	39	.	.	PUNCT
admet-373	179	1	we	we	PRON
admet-373	179	2	can	can	AUX
admet-373	179	3	depict	depict	VERB
admet-373	179	4	a	a	DET
admet-373	179	5	simplified	simplified	ADJ
admet-373	179	6	model	model	NOUN
admet-373	179	7	as	as	SCONJ
admet-373	179	8	it	it	PRON
admet-373	179	9	was	be	AUX
admet-373	179	10	described	describe	VERB
admet-373	179	11	by	by	ADP
admet-373	179	12	stepensky	stepensky	ADJ
admet-373	179	13	[	[	X
admet-373	179	14	15,61	15,61	X
admet-373	179	15	]	]	PUNCT
admet-373	179	16	and	and	CCONJ
admet-373	179	17	consider	consider	VERB
admet-373	179	18	that	that	SCONJ
admet-373	179	19	the	the	DET
admet-373	179	20	dosing	dosing	NOUN
admet-373	179	21	amount	amount	NOUN
admet-373	179	22	and	and	CCONJ
admet-373	179	23	frequency	frequency	NOUN
admet-373	179	24	required	require	VERB
admet-373	179	25	to	to	PART
admet-373	179	26	balance	balance	VERB
admet-373	179	27	the	the	DET
admet-373	179	28	elimination	elimination	NOUN
admet-373	179	29	rate	rate	NOUN
admet-373	179	30	of	of	ADP
admet-373	179	31	a	a	DET
admet-373	179	32	compound	compound	NOUN
admet-373	179	33	determines	determine	VERB
admet-373	179	34	the	the	DET
admet-373	179	35	amount	amount	NOUN
admet-373	179	36	of	of	ADP
admet-373	179	37	drug	drug	NOUN
admet-373	179	38	in	in	ADP
admet-373	179	39	the	the	DET
admet-373	179	40	body	body	NOUN
admet-373	179	41	.	.	PUNCT
admet-373	180	1	while	while	SCONJ
admet-373	180	2	the	the	DET
admet-373	180	3	volume	volume	NOUN
admet-373	180	4	of	of	ADP
admet-373	180	5	distribution	distribution	NOUN
admet-373	180	6	describes	describe	VERB
admet-373	180	7	how	how	SCONJ
admet-373	180	8	the	the	DET
admet-373	180	9	total	total	ADJ
admet-373	180	10	amount	amount	NOUN
admet-373	180	11	of	of	ADP
admet-373	180	12	drug	drug	NOUN
admet-373	180	13	distributes	distribute	VERB
admet-373	180	14	between	between	ADP
admet-373	180	15	the	the	DET
admet-373	180	16	tissue	tissue	NOUN
admet-373	180	17	and	and	CCONJ
admet-373	180	18	plasma	plasma	NOUN
admet-373	180	19	compartment	compartment	NOUN
admet-373	180	20	,	,	PUNCT
admet-373	180	21	unbound	unbound	NOUN
admet-373	180	22	volume	volume	NOUN
admet-373	180	23	of	of	ADP
admet-373	180	24	distribution	distribution	NOUN
admet-373	180	25	describes	describe	VERB
admet-373	180	26	the	the	DET
admet-373	180	27	drug	drug	NOUN
admet-373	180	28	distribution	distribution	NOUN
admet-373	180	29	between	between	ADP
admet-373	180	30	the	the	DET
admet-373	180	31	free	free	ADJ
admet-373	180	32	and	and	CCONJ
admet-373	180	33	bound	bound	ADJ
admet-373	180	34	compartments	compartment	NOUN
admet-373	180	35	regardless	regardless	ADV
admet-373	180	36	of	of	ADP
admet-373	180	37	the	the	DET
admet-373	180	38	location	location	NOUN
admet-373	180	39	where	where	SCONJ
admet-373	180	40	the	the	DET
admet-373	180	41	drug	drug	NOUN
admet-373	180	42	binds	bind	VERB
admet-373	180	43	(	(	PUNCT
admet-373	180	44	tissues	tissue	NOUN
admet-373	180	45	or	or	CCONJ
admet-373	180	46	plasma	plasma	NOUN
admet-373	180	47	proteins	protein	NOUN
admet-373	180	48	,	,	PUNCT
admet-373	180	49	see	see	VERB
admet-373	180	50	figure	figure	NOUN
admet-373	180	51	3	3	NUM
admet-373	180	52	)	)	PUNCT
admet-373	180	53	.	.	PUNCT
admet-373	181	1	while	while	SCONJ
admet-373	181	2	investigating	investigate	VERB
admet-373	181	3	known	known	ADJ
admet-373	181	4	drugs	drug	NOUN
admet-373	181	5	it	it	PRON
admet-373	181	6	was	be	AUX
admet-373	181	7	clear	clear	ADJ
admet-373	181	8	that	that	SCONJ
admet-373	181	9	the	the	DET
admet-373	181	10	volume	volume	NOUN
admet-373	181	11	of	of	ADP
admet-373	181	12	distribution	distribution	NOUN
admet-373	181	13	showed	show	VERB
admet-373	181	14	no	no	DET
admet-373	181	15	correlation	correlation	NOUN
admet-373	181	16	alone	alone	ADV
admet-373	181	17	to	to	PART
admet-373	181	18	clearance	clearance	VERB
admet-373	181	19	or	or	CCONJ
admet-373	181	20	half	half	ADJ
admet-373	181	21	-	-	PUNCT
admet-373	181	22	life	life	NOUN
admet-373	181	23	.	.	PUNCT
admet-373	182	1	however	however	ADV
admet-373	182	2	,	,	PUNCT
admet-373	182	3	it	it	PRON
admet-373	182	4	did	do	AUX
admet-373	182	5	show	show	VERB
admet-373	182	6	a	a	DET
admet-373	182	7	good	good	ADJ
admet-373	182	8	correlation	correlation	NOUN
admet-373	182	9	with	with	ADP
admet-373	182	10	the	the	DET
admet-373	182	11	product	product	NOUN
admet-373	182	12	term	term	NOUN
admet-373	182	13	(	(	PUNCT
admet-373	182	14	or	or	CCONJ
admet-373	182	15	the	the	DET
admet-373	182	16	sum	sum	NOUN
admet-373	182	17	of	of	ADP
admet-373	182	18	their	their	PRON
admet-373	182	19	logarithmic	logarithmic	ADJ
admet-373	182	20	values	value	NOUN
admet-373	182	21	clearance	clearance	NOUN
admet-373	182	22	and	and	CCONJ
admet-373	182	23	half	half	ADJ
admet-373	182	24	-	-	PUNCT
admet-373	182	25	life	life	NOUN
admet-373	182	26	)	)	PUNCT
admet-373	182	27	as	as	SCONJ
admet-373	182	28	is	be	AUX
admet-373	182	29	shown	show	VERB
admet-373	182	30	in	in	ADP
admet-373	182	31	figure	figure	NOUN
admet-373	182	32	4a	4a	NUM
admet-373	182	33	,	,	PUNCT
admet-373	182	34	b	b	PROPN
admet-373	182	35	and	and	CCONJ
admet-373	182	36	c.	c.	PROPN
admet-373	182	37	the	the	DET
admet-373	182	38	data	data	NOUN
admet-373	182	39	supports	support	VERB
admet-373	182	40	the	the	DET
admet-373	182	41	statement	statement	NOUN
admet-373	182	42	that	that	SCONJ
admet-373	182	43	the	the	DET
admet-373	182	44	distribution	distribution	NOUN
admet-373	182	45	properties	property	NOUN
admet-373	182	46	of	of	ADP
admet-373	182	47	compounds	compound	NOUN
admet-373	182	48	are	be	AUX
admet-373	182	49	an	an	DET
admet-373	182	50	independent	independent	ADJ
admet-373	182	51	parameter	parameter	NOUN
admet-373	182	52	from	from	ADP
admet-373	182	53	the	the	DET
admet-373	182	54	clearance	clearance	NOUN
admet-373	182	55	.	.	PUNCT
admet-373	183	1	figure	figure	NOUN
admet-373	183	2	3	3	NUM
admet-373	183	3	.	.	PUNCT
admet-373	184	1	the	the	DET
admet-373	184	2	schematic	schematic	ADJ
admet-373	184	3	absorption	absorption	NOUN
admet-373	184	4	,	,	PUNCT
admet-373	184	5	distribution	distribution	NOUN
admet-373	184	6	and	and	CCONJ
admet-373	184	7	elimination	elimination	NOUN
admet-373	184	8	process	process	NOUN
admet-373	184	9	the	the	DET
admet-373	184	10	tissue	tissue	NOUN
admet-373	184	11	/	/	SYM
admet-373	184	12	plasma	plasma	NOUN
admet-373	184	13	partition	partition	NOUN
admet-373	184	14	coefficient	coefficient	NOUN
admet-373	184	15	of	of	ADP
admet-373	184	16	a	a	DET
admet-373	184	17	compound	compound	NOUN
admet-373	184	18	can	can	AUX
admet-373	184	19	be	be	AUX
admet-373	184	20	defined	define	VERB
admet-373	184	21	as	as	ADP
admet-373	184	22	the	the	DET
admet-373	184	23	tissue	tissue	NOUN
admet-373	184	24	concentration	concentration	NOUN
admet-373	184	25	divided	divide	VERB
admet-373	184	26	by	by	ADP
admet-373	184	27	the	the	DET
admet-373	184	28	plasma	plasma	NOUN
admet-373	184	29	concentration	concentration	NOUN
admet-373	184	30	of	of	ADP
admet-373	184	31	the	the	DET
admet-373	184	32	compounds	compound	NOUN
admet-373	184	33	.	.	PUNCT
admet-373	185	1	the	the	DET
admet-373	185	2	concentration	concentration	NOUN
admet-373	185	3	can	can	AUX
admet-373	185	4	be	be	AUX
admet-373	185	5	expressed	express	VERB
admet-373	185	6	as	as	ADP
admet-373	185	7	the	the	DET
admet-373	185	8	amount	amount	NOUN
admet-373	185	9	of	of	ADP
admet-373	185	10	drug	drug	NOUN
admet-373	185	11	in	in	ADP
admet-373	185	12	the	the	DET
admet-373	185	13	tissue	tissue	NOUN
admet-373	185	14	and	and	CCONJ
admet-373	185	15	plasma	plasma	NOUN
admet-373	185	16	volume	volume	NOUN
admet-373	185	17	respectively	respectively	ADV
admet-373	185	18	,	,	PUNCT
admet-373	185	19	so	so	ADV
admet-373	185	20	ktissue	ktissue	NOUN
admet-373	185	21	/	/	SYM
admet-373	185	22	plasma	plasma	NOUN
admet-373	185	23	can	can	AUX
admet-373	185	24	be	be	AUX
admet-373	185	25	described	describe	VERB
admet-373	185	26	by	by	ADP
admet-373	185	27	equation	equation	NOUN
admet-373	185	28	5	5	NUM
admet-373	185	29	:	:	PUNCT
admet-373	186	1	𝐾𝑡𝑖𝑠𝑠𝑢𝑒	𝐾𝑡𝑖𝑠𝑠𝑢𝑒	PROPN
admet-373	186	2	𝑝𝑙𝑎𝑠𝑚𝑎⁄	𝑝𝑙𝑎𝑠𝑚𝑎⁄	X
admet-373	186	3	=	=	PUNCT
admet-373	186	4	(	(	PUNCT
admet-373	186	5	𝐷𝑜𝑠𝑒−𝐴𝑝	𝐷𝑜𝑠𝑒−𝐴𝑝	NOUN
admet-373	186	6	)	)	PUNCT
admet-373	186	7	𝑉𝑡⁄	𝑉𝑡⁄	PUNCT
admet-373	187	1	𝐴𝑝	𝐴𝑝	X
admet-373	187	2	𝑉𝑝⁄	𝑉𝑝⁄	X
admet-373	187	3	(	(	PUNCT
admet-373	187	4	5	5	NUM
admet-373	187	5	)	)	PUNCT
admet-373	187	6	where	where	SCONJ
admet-373	187	7	the	the	DET
admet-373	187	8	amount	amount	NOUN
admet-373	187	9	of	of	ADP
admet-373	187	10	drug	drug	NOUN
admet-373	187	11	in	in	ADP
admet-373	187	12	tissues	tissue	NOUN
admet-373	187	13	equals	equal	VERB
admet-373	187	14	the	the	DET
admet-373	187	15	dose	dose	NOUN
admet-373	187	16	minus	minus	ADP
admet-373	187	17	the	the	DET
admet-373	187	18	amount	amount	NOUN
admet-373	187	19	in	in	ADP
admet-373	187	20	plasma	plasma	NOUN
admet-373	187	21	(	(	PUNCT
admet-373	187	22	ap	ap	PROPN
admet-373	187	23	)	)	PUNCT
admet-373	187	24	,	,	PUNCT
admet-373	187	25	vt	vt	PROPN
admet-373	187	26	is	be	AUX
admet-373	187	27	the	the	DET
admet-373	187	28	tissue	tissue	NOUN
admet-373	187	29	volume	volume	NOUN
admet-373	187	30	,	,	PUNCT
admet-373	187	31	vp	vp	PROPN
admet-373	187	32	is	be	AUX
admet-373	187	33	the	the	DET
admet-373	187	34	plasma	plasma	NOUN
admet-373	187	35	volume	volume	NOUN
admet-373	187	36	.	.	PUNCT
admet-373	188	1	as	as	ADP
admet-373	188	2	the	the	DET
admet-373	188	3	steady	steady	ADJ
admet-373	188	4	-	-	PUNCT
admet-373	188	5	state	state	NOUN
admet-373	188	6	volume	volume	NOUN
admet-373	188	7	of	of	ADP
admet-373	188	8	distribution	distribution	NOUN
admet-373	188	9	(	(	PUNCT
admet-373	188	10	vdss	vdss	ADV
admet-373	188	11	)	)	PUNCT
admet-373	188	12	equals	equal	VERB
admet-373	188	13	the	the	DET
admet-373	188	14	dose	dose	NOUN
admet-373	188	15	over	over	ADP
admet-373	188	16	the	the	DET
admet-373	188	17	valko	valko	NOUN
admet-373	188	18	,	,	PUNCT
admet-373	188	19	teague	teague	NOUN
admet-373	188	20	and	and	CCONJ
admet-373	188	21	pidgeon	pidgeon	PROPN
admet-373	188	22	admet	admet	PROPN
admet-373	188	23	&	&	CCONJ
admet-373	188	24	dmpk	dmpk	PROPN
admet-373	188	25	5(1	5(1	NUM
admet-373	188	26	)	)	PUNCT
admet-373	188	27	(	(	PUNCT
admet-373	188	28	2017	2017	NUM
admet-373	188	29	)	)	PUNCT
admet-373	188	30	14	14	NUM
admet-373	188	31	-	-	SYM
admet-373	188	32	38	38	NUM
admet-373	188	33	24	24	NUM
admet-373	188	34	plasma	plasma	NOUN
admet-373	188	35	concentration	concentration	NOUN
admet-373	188	36	,	,	PUNCT
admet-373	188	37	introducing	introduce	VERB
admet-373	188	38	that	that	PRON
admet-373	188	39	into	into	ADP
admet-373	188	40	equation	equation	NOUN
admet-373	188	41	5	5	NUM
admet-373	188	42	we	we	PRON
admet-373	188	43	can	can	AUX
admet-373	188	44	express	express	VERB
admet-373	188	45	the	the	DET
admet-373	188	46	tissue	tissue	NOUN
admet-373	188	47	plasma	plasma	NOUN
admet-373	188	48	partition	partition	NOUN
admet-373	188	49	as	as	ADP
admet-373	188	50	a	a	DET
admet-373	188	51	proportionality	proportionality	NOUN
admet-373	188	52	term	term	NOUN
admet-373	188	53	to	to	ADP
admet-373	188	54	the	the	DET
admet-373	188	55	steady	steady	ADJ
admet-373	188	56	state	state	NOUN
admet-373	188	57	volume	volume	NOUN
admet-373	188	58	of	of	ADP
admet-373	188	59	distribution	distribution	NOUN
admet-373	188	60	shown	show	VERB
admet-373	188	61	in	in	ADP
admet-373	188	62	equation	equation	NOUN
admet-373	188	63	6	6	NUM
admet-373	188	64	.	.	PUNCT
admet-373	189	1	𝐾𝑡𝑖𝑠𝑠𝑢𝑒	𝐾𝑡𝑖𝑠𝑠𝑢𝑒	PROPN
admet-373	189	2	𝑝𝑙𝑎𝑠𝑚𝑎⁄	𝑝𝑙𝑎𝑠𝑚𝑎⁄	X
admet-373	189	3	=	=	X
admet-373	189	4	𝑉𝑑𝑠𝑠−𝑉𝑝	𝑉𝑑𝑠𝑠−𝑉𝑝	PROPN
admet-373	189	5	𝑉𝑡	𝑉𝑡	PROPN
admet-373	189	6	(	(	PUNCT
admet-373	189	7	6	6	NUM
admet-373	189	8	)	)	PUNCT
admet-373	189	9	in	in	ADP
admet-373	189	10	turn	turn	NOUN
admet-373	189	11	,	,	PUNCT
admet-373	189	12	the	the	DET
admet-373	189	13	volume	volume	NOUN
admet-373	189	14	of	of	ADP
admet-373	189	15	distribution	distribution	NOUN
admet-373	189	16	of	of	ADP
admet-373	189	17	marketed	market	VERB
admet-373	189	18	drugs	drug	NOUN
admet-373	189	19	could	could	AUX
admet-373	189	20	be	be	AUX
admet-373	189	21	modeled	model	VERB
admet-373	189	22	by	by	ADP
admet-373	189	23	the	the	DET
admet-373	189	24	difference	difference	NOUN
admet-373	189	25	in	in	ADP
admet-373	189	26	the	the	DET
admet-373	189	27	membrane	membrane	NOUN
admet-373	189	28	and	and	CCONJ
admet-373	189	29	the	the	DET
admet-373	189	30	protein	protein	NOUN
admet-373	189	31	binding	bind	VERB
admet-373	189	32	of	of	ADP
admet-373	189	33	compounds	compound	NOUN
admet-373	189	34	as	as	SCONJ
admet-373	189	35	described	describe	VERB
admet-373	189	36	by	by	ADP
admet-373	189	37	equation	equation	NOUN
admet-373	189	38	3	3	NUM
admet-373	189	39	and	and	CCONJ
admet-373	189	40	shown	show	VERB
admet-373	189	41	in	in	ADP
admet-373	189	42	figure	figure	NOUN
admet-373	189	43	5	5	NUM
admet-373	189	44	for	for	ADP
admet-373	189	45	the	the	DET
admet-373	189	46	investigated	investigate	VERB
admet-373	189	47	compounds	compound	NOUN
admet-373	189	48	.	.	PUNCT
admet-373	190	1	there	there	PRON
admet-373	190	2	are	be	VERB
admet-373	190	3	only	only	ADV
admet-373	190	4	40	40	NUM
admet-373	190	5	compounds	compound	NOUN
admet-373	190	6	that	that	PRON
admet-373	190	7	have	have	AUX
admet-373	190	8	been	be	AUX
admet-373	190	9	included	include	VERB
admet-373	190	10	in	in	ADP
admet-373	190	11	the	the	DET
admet-373	190	12	training	training	NOUN
admet-373	190	13	set	set	NOUN
admet-373	190	14	,	,	PUNCT
admet-373	190	15	the	the	DET
admet-373	190	16	majority	majority	NOUN
admet-373	190	17	of	of	ADP
admet-373	190	18	the	the	DET
admet-373	190	19	compounds	compound	NOUN
admet-373	190	20	were	be	AUX
admet-373	190	21	not	not	PART
admet-373	190	22	included	include	VERB
admet-373	190	23	in	in	ADP
admet-373	190	24	the	the	DET
admet-373	190	25	original	original	ADJ
admet-373	190	26	model	model	NOUN
admet-373	190	27	.	.	PUNCT
admet-373	191	1	that	that	PRON
admet-373	191	2	explains	explain	VERB
admet-373	191	3	that	that	SCONJ
admet-373	191	4	the	the	DET
admet-373	191	5	statistics	statistic	NOUN
admet-373	191	6	are	be	AUX
admet-373	191	7	slightly	slightly	ADV
admet-373	191	8	worse	bad	ADJ
admet-373	191	9	(	(	PUNCT
admet-373	191	10	r2	r2	NOUN
admet-373	191	11	=	=	SYM
admet-373	191	12	0.76	0.76	NUM
admet-373	191	13	;	;	PUNCT
admet-373	191	14	root	root	NOUN
admet-373	191	15	mean	mean	VERB
admet-373	191	16	square	square	NOUN
admet-373	191	17	error	error	NOUN
admet-373	191	18	=	=	NOUN
admet-373	191	19	0.33	0.33	NUM
admet-373	191	20	in	in	ADP
admet-373	191	21	the	the	DET
admet-373	191	22	original	original	ADJ
admet-373	191	23	model	model	NOUN
admet-373	191	24	,	,	PUNCT
admet-373	191	25	while	while	SCONJ
admet-373	191	26	here	here	ADV
admet-373	191	27	the	the	DET
admet-373	191	28	r2	r2	PROPN
admet-373	191	29	=	=	PROPN
admet-373	191	30	0.57	0.57	NUM
admet-373	191	31	and	and	CCONJ
admet-373	191	32	root	root	NOUN
admet-373	191	33	mean	mean	NOUN
admet-373	191	34	square	square	NOUN
admet-373	191	35	error	error	NOUN
admet-373	191	36	=	=	NOUN
admet-373	191	37	0.40	0.40	NUM
admet-373	191	38	)	)	PUNCT
admet-373	191	39	.	.	PUNCT
admet-373	192	1	figure	figure	VERB
admet-373	192	2	4	4	NUM
admet-373	192	3	.	.	PUNCT
admet-373	193	1	the	the	DET
admet-373	193	2	plot	plot	NOUN
admet-373	193	3	of	of	ADP
admet-373	193	4	log	log	NOUN
admet-373	193	5	vdss	vdss	ADV
admet-373	193	6	vs	vs	ADP
admet-373	193	7	log	log	NOUN
admet-373	193	8	in	in	ADP
admet-373	193	9	vivo	vivo	NOUN
admet-373	193	10	cl	cl	NOUN
admet-373	193	11	(	(	PUNCT
admet-373	193	12	a	a	X
admet-373	193	13	)	)	PUNCT
admet-373	193	14	,	,	PUNCT
admet-373	193	15	log	log	VERB
admet-373	193	16	vdss	vdss	ADV
admet-373	193	17	vs	vs	ADP
admet-373	193	18	log	log	NOUN
admet-373	193	19	t½	t½	PROPN
admet-373	193	20	(	(	PUNCT
admet-373	193	21	b	b	NOUN
admet-373	193	22	)	)	PUNCT
admet-373	193	23	and	and	CCONJ
admet-373	193	24	log	log	VERB
admet-373	193	25	vdss	vdss	ADV
admet-373	193	26	vs	vs	ADP
admet-373	193	27	the	the	DET
admet-373	193	28	sum	sum	NOUN
admet-373	193	29	of	of	ADP
admet-373	193	30	log	log	NOUN
admet-373	193	31	cl	cl	NOUN
admet-373	193	32	and	and	CCONJ
admet-373	193	33	log	log	VERB
admet-373	193	34	t½.	t½.	ADP
admet-373	193	35	the	the	DET
admet-373	193	36	unbound	unbound	NOUN
admet-373	193	37	volume	volume	NOUN
admet-373	193	38	of	of	ADP
admet-373	193	39	distribution	distribution	NOUN
admet-373	193	40	is	be	AUX
admet-373	193	41	in	in	ADP
admet-373	193	42	principle	principle	NOUN
admet-373	193	43	the	the	DET
admet-373	193	44	reciprocal	reciprocal	ADJ
admet-373	193	45	value	value	NOUN
admet-373	193	46	of	of	ADP
admet-373	193	47	the	the	DET
admet-373	193	48	maximum	maximum	ADJ
admet-373	193	49	drug	drug	NOUN
admet-373	193	50	efficiency	efficiency	NOUN
admet-373	193	51	(	(	PUNCT
admet-373	193	52	demax	demax	NOUN
admet-373	193	53	)	)	PUNCT
admet-373	193	54	defined	define	VERB
admet-373	193	55	by	by	ADP
admet-373	193	56	braggio	braggio	NOUN
admet-373	193	57	et	et	PROPN
admet-373	193	58	al	al	PROPN
admet-373	193	59	.	.	PUNCT
admet-373	194	1	[	[	X
admet-373	194	2	18	18	NUM
admet-373	194	3	]	]	PUNCT
admet-373	194	4	,	,	PUNCT
admet-373	194	5	that	that	PRON
admet-373	194	6	is	be	AUX
admet-373	194	7	defined	define	VERB
admet-373	194	8	by	by	ADP
admet-373	194	9	the	the	DET
admet-373	194	10	proportion	proportion	NOUN
admet-373	194	11	of	of	ADP
admet-373	194	12	the	the	DET
admet-373	194	13	free	free	ADJ
admet-373	194	14	bio	bio	NOUN
admet-373	194	15	-	-	ADJ
admet-373	194	16	phase	phase	NOUN
admet-373	194	17	concentration	concentration	NOUN
admet-373	194	18	and	and	CCONJ
admet-373	194	19	the	the	DET
admet-373	194	20	dose	dose	NOUN
admet-373	194	21	.	.	PUNCT
admet-373	195	1	if	if	SCONJ
admet-373	195	2	the	the	DET
admet-373	195	3	free	free	ADJ
admet-373	195	4	drug	drug	NOUN
admet-373	195	5	hypothesis	hypothesis	NOUN
admet-373	195	6	is	be	AUX
admet-373	195	7	true	true	ADJ
admet-373	195	8	,	,	PUNCT
admet-373	195	9	which	which	PRON
admet-373	195	10	means	mean	VERB
admet-373	195	11	the	the	DET
admet-373	195	12	free	free	ADJ
admet-373	195	13	plasma	plasma	NOUN
admet-373	195	14	concentration	concentration	NOUN
admet-373	195	15	if	if	SCONJ
admet-373	195	16	similar	similar	ADJ
admet-373	195	17	to	to	ADP
admet-373	195	18	(	(	PUNCT
admet-373	195	19	a	a	X
admet-373	195	20	)	)	PUNCT
admet-373	195	21	(	(	PUNCT
admet-373	195	22	b	b	X
admet-373	195	23	)	)	PUNCT
admet-373	195	24	(	(	PUNCT
admet-373	195	25	c	c	X
admet-373	195	26	)	)	PUNCT
admet-373	195	27	admet	admet	PROPN
admet-373	195	28	&	&	CCONJ
admet-373	195	29	dmpk	dmpk	PROPN
admet-373	195	30	5(1	5(1	NUM
admet-373	195	31	)	)	PUNCT
admet-373	195	32	(	(	PUNCT
admet-373	195	33	2017	2017	NUM
admet-373	195	34	)	)	PUNCT
admet-373	195	35	14	14	NUM
admet-373	195	36	-	-	SYM
admet-373	195	37	38	38	NUM
admet-373	195	38	in	in	ADP
admet-373	195	39	vitro	vitro	X
admet-373	195	40	membrane	membrane	NOUN
admet-373	195	41	and	and	CCONJ
admet-373	195	42	protein	protein	NOUN
admet-373	195	43	binding	bind	VERB
admet-373	195	44	doi	doi	NOUN
admet-373	195	45	:	:	PUNCT
admet-373	195	46	10.5599	10.5599	NUM
admet-373	195	47	/	/	SYM
admet-373	195	48	admet.5.1.373	admet.5.1.373	ADP
admet-373	195	49	25	25	NUM
admet-373	195	50	the	the	DET
admet-373	195	51	free	free	ADJ
admet-373	195	52	tissue	tissue	NOUN
admet-373	195	53	concentration	concentration	NOUN
admet-373	195	54	of	of	ADP
admet-373	195	55	the	the	DET
admet-373	195	56	compounds	compound	NOUN
admet-373	195	57	when	when	SCONJ
admet-373	195	58	no	no	DET
admet-373	195	59	permeability	permeability	NOUN
admet-373	195	60	barrier	barrier	NOUN
admet-373	195	61	or	or	CCONJ
admet-373	195	62	active	active	ADJ
admet-373	195	63	transport	transport	NOUN
admet-373	195	64	distorts	distort	VERB
admet-373	195	65	the	the	DET
admet-373	195	66	equilibrium	equilibrium	NOUN
admet-373	195	67	,	,	PUNCT
admet-373	195	68	then	then	ADV
admet-373	195	69	the	the	DET
admet-373	195	70	model	model	NOUN
admet-373	195	71	for	for	ADP
admet-373	195	72	the	the	DET
admet-373	195	73	unbound	unbound	NOUN
admet-373	195	74	volume	volume	NOUN
admet-373	195	75	of	of	ADP
admet-373	195	76	distribution	distribution	NOUN
admet-373	195	77	can	can	AUX
admet-373	195	78	be	be	AUX
admet-373	195	79	used	use	VERB
admet-373	195	80	to	to	PART
admet-373	195	81	estimate	estimate	VERB
admet-373	195	82	the	the	DET
admet-373	195	83	maximum	maximum	ADJ
admet-373	195	84	drug	drug	NOUN
admet-373	195	85	efficiency	efficiency	NOUN
admet-373	195	86	(	(	PUNCT
admet-373	195	87	demax	demax	NOUN
admet-373	195	88	)	)	PUNCT
admet-373	195	89	of	of	ADP
admet-373	195	90	the	the	DET
admet-373	195	91	compounds	compound	NOUN
admet-373	195	92	.	.	PUNCT
admet-373	196	1	based	base	VERB
admet-373	196	2	on	on	ADP
admet-373	196	3	the	the	DET
admet-373	196	4	definition	definition	NOUN
admet-373	196	5	of	of	ADP
admet-373	196	6	the	the	DET
admet-373	196	7	vdu	vdu	PROPN
admet-373	196	8	and	and	CCONJ
admet-373	196	9	demax	demax	PROPN
admet-373	196	10	,	,	PUNCT
admet-373	196	11	their	their	PRON
admet-373	196	12	relationship	relationship	NOUN
admet-373	196	13	can	can	AUX
admet-373	196	14	be	be	AUX
admet-373	196	15	described	describe	VERB
admet-373	196	16	by	by	ADP
admet-373	196	17	equation	equation	NOUN
admet-373	196	18	7	7	NUM
admet-373	196	19	.	.	PUNCT
admet-373	197	1	𝐷𝐸𝑚𝑎𝑥	𝐷𝐸𝑚𝑎𝑥	PROPN
admet-373	197	2	=	=	PUNCT
admet-373	197	3	100	100	NUM
admet-373	197	4	𝑉𝑑𝑢	𝑉𝑑𝑢	PROPN
admet-373	197	5	(	(	PUNCT
admet-373	197	6	7	7	NUM
admet-373	197	7	)	)	PUNCT
admet-373	197	8	figure	figure	NOUN
admet-373	197	9	6	6	NUM
admet-373	197	10	shows	show	VERB
admet-373	197	11	the	the	DET
admet-373	197	12	unbound	unbound	NOUN
admet-373	197	13	volume	volume	NOUN
admet-373	197	14	of	of	ADP
admet-373	197	15	distribution	distribution	NOUN
admet-373	197	16	and	and	CCONJ
admet-373	197	17	the	the	DET
admet-373	197	18	estimated	estimate	VERB
admet-373	197	19	demax	demax	NOUN
admet-373	197	20	of	of	ADP
admet-373	197	21	the	the	DET
admet-373	197	22	marketed	market	VERB
admet-373	197	23	drugs	drug	NOUN
admet-373	197	24	listed	list	VERB
admet-373	197	25	in	in	ADP
admet-373	197	26	table	table	NOUN
admet-373	197	27	a1	a1	NOUN
admet-373	197	28	.	.	PUNCT
admet-373	198	1	in	in	ADP
admet-373	198	2	this	this	DET
admet-373	198	3	case	case	NOUN
admet-373	198	4	,	,	PUNCT
admet-373	198	5	only	only	ADV
admet-373	198	6	10	10	NUM
admet-373	198	7	compounds	compound	NOUN
admet-373	198	8	overlapped	overlap	VERB
admet-373	198	9	with	with	ADP
admet-373	198	10	the	the	DET
admet-373	198	11	original	original	ADJ
admet-373	198	12	training	training	NOUN
admet-373	198	13	set	set	NOUN
admet-373	198	14	.	.	PUNCT
admet-373	199	1	most	most	ADJ
admet-373	199	2	of	of	ADP
admet-373	199	3	the	the	DET
admet-373	199	4	compounds	compound	NOUN
admet-373	199	5	can	can	AUX
admet-373	199	6	be	be	AUX
admet-373	199	7	considered	consider	VERB
admet-373	199	8	as	as	ADP
admet-373	199	9	a	a	DET
admet-373	199	10	test	test	NOUN
admet-373	199	11	set	set	NOUN
admet-373	199	12	.	.	PUNCT
admet-373	200	1	the	the	DET
admet-373	200	2	root	root	NOUN
admet-373	200	3	-	-	PUNCT
admet-373	200	4	mean	mean	ADJ
admet-373	200	5	-	-	PUNCT
admet-373	200	6	square	square	NOUN
admet-373	200	7	error	error	NOUN
admet-373	200	8	increased	increase	VERB
admet-373	200	9	from	from	ADP
admet-373	200	10	0.32	0.32	NUM
admet-373	200	11	to	to	ADP
admet-373	200	12	0.45	0.45	NUM
admet-373	200	13	while	while	SCONJ
admet-373	200	14	the	the	DET
admet-373	200	15	r2	r2	NOUN
admet-373	200	16	dropped	drop	VERB
admet-373	200	17	from	from	ADP
admet-373	200	18	0.84	0.84	NUM
admet-373	200	19	to	to	ADP
admet-373	200	20	0.66	0.66	NUM
admet-373	200	21	.	.	PUNCT
admet-373	201	1	the	the	DET
admet-373	201	2	statistics	statistic	NOUN
admet-373	201	3	for	for	ADP
admet-373	201	4	the	the	DET
admet-373	201	5	training	training	NOUN
admet-373	201	6	set	set	NOUN
admet-373	201	7	is	be	AUX
admet-373	201	8	r2	r2	NOUN
admet-373	201	9	=	=	PUNCT
admet-373	201	10	0.76	0.76	NUM
admet-373	201	11	and	and	CCONJ
admet-373	201	12	the	the	DET
admet-373	201	13	standard	standard	ADJ
admet-373	201	14	error	error	NOUN
admet-373	201	15	of	of	ADP
admet-373	201	16	the	the	DET
admet-373	201	17	estimate	estimate	NOUN
admet-373	201	18	is	be	AUX
admet-373	201	19	s	s	NOUN
admet-373	201	20	=	=	NOUN
admet-373	201	21	0.33	0.33	NUM
admet-373	201	22	.	.	PUNCT
admet-373	202	1	the	the	DET
admet-373	202	2	estimates	estimate	NOUN
admet-373	202	3	can	can	AUX
admet-373	202	4	be	be	AUX
admet-373	202	5	considered	consider	VERB
admet-373	202	6	as	as	ADP
admet-373	202	7	very	very	ADV
admet-373	202	8	predictive	predictive	ADJ
admet-373	202	9	,	,	PUNCT
admet-373	202	10	as	as	SCONJ
admet-373	202	11	we	we	PRON
admet-373	202	12	have	have	AUX
admet-373	202	13	just	just	ADV
admet-373	202	14	used	use	VERB
admet-373	202	15	two	two	NUM
admet-373	202	16	major	major	ADJ
admet-373	202	17	binding	bind	VERB
admet-373	202	18	components	component	NOUN
admet-373	202	19	in	in	ADP
admet-373	202	20	the	the	DET
admet-373	202	21	body	body	NOUN
admet-373	202	22	to	to	PART
admet-373	202	23	describe	describe	VERB
admet-373	202	24	the	the	DET
admet-373	202	25	total	total	ADJ
admet-373	202	26	non	non	ADJ
admet-373	202	27	-	-	ADJ
admet-373	202	28	specific	specific	ADJ
admet-373	202	29	binding	binding	NOUN
admet-373	202	30	of	of	ADP
admet-373	202	31	the	the	DET
admet-373	202	32	compounds	compound	NOUN
admet-373	202	33	to	to	ADP
admet-373	202	34	the	the	DET
admet-373	202	35	phospholipids	phospholipid	NOUN
admet-373	202	36	and	and	CCONJ
admet-373	202	37	albumin	albumin	ADJ
admet-373	202	38	type	type	NOUN
admet-373	202	39	of	of	ADP
admet-373	202	40	proteins	protein	NOUN
admet-373	202	41	.	.	PUNCT
admet-373	203	1	figure	figure	NOUN
admet-373	203	2	5	5	NUM
admet-373	203	3	.	.	PUNCT
admet-373	204	1	the	the	DET
admet-373	204	2	observed	observed	ADJ
admet-373	204	3	in	in	ADP
admet-373	204	4	vivo	vivo	NOUN
admet-373	204	5	log	log	NOUN
admet-373	204	6	vdss	vdss	ADV
admet-373	204	7	vs	vs	ADP
admet-373	204	8	the	the	DET
admet-373	204	9	estimated	estimate	VERB
admet-373	204	10	vdss	vdss	ADV
admet-373	204	11	by	by	ADP
admet-373	204	12	the	the	DET
admet-373	204	13	iam	iam	PROPN
admet-373	204	14	mb	mb	PROPN
admet-373	204	15	/	/	SYM
admet-373	204	16	pb	pb	ADP
admet-373	204	17	technology	technology	NOUN
admet-373	204	18	®	®	NOUN
admet-373	204	19	using	use	VERB
admet-373	204	20	equation	equation	NOUN
admet-373	204	21	3	3	NUM
admet-373	204	22	.	.	PUNCT
admet-373	204	23	figure	figure	NOUN
admet-373	204	24	6	6	NUM
admet-373	204	25	.	.	PUNCT
admet-373	205	1	the	the	DET
admet-373	205	2	plot	plot	NOUN
admet-373	205	3	of	of	ADP
admet-373	205	4	the	the	DET
admet-373	205	5	human	human	ADJ
admet-373	205	6	unbound	unbound	NOUN
admet-373	205	7	volume	volume	NOUN
admet-373	205	8	of	of	ADP
admet-373	205	9	distribution	distribution	NOUN
admet-373	205	10	and	and	CCONJ
admet-373	205	11	the	the	DET
admet-373	205	12	estimated	estimate	VERB
admet-373	205	13	demax	demax	NOUN
admet-373	205	14	using	use	VERB
admet-373	205	15	the	the	DET
admet-373	205	16	iam	iam	PROPN
admet-373	205	17	mb	mb	PROPN
admet-373	205	18	/	/	SYM
admet-373	205	19	pb	pb	X
admet-373	205	20	technology	technology	NOUN
admet-373	205	21	and	and	CCONJ
admet-373	205	22	equation	equation	NOUN
admet-373	205	23	4	4	NUM
admet-373	205	24	.	.	PUNCT
admet-373	205	25	valko	valko	PROPN
admet-373	205	26	,	,	PUNCT
admet-373	205	27	teague	teague	NOUN
admet-373	205	28	and	and	CCONJ
admet-373	205	29	pidgeon	pidgeon	PROPN
admet-373	205	30	admet	admet	PROPN
admet-373	205	31	&	&	CCONJ
admet-373	205	32	dmpk	dmpk	PROPN
admet-373	205	33	5(1	5(1	NUM
admet-373	205	34	)	)	PUNCT
admet-373	205	35	(	(	PUNCT
admet-373	205	36	2017	2017	NUM
admet-373	205	37	)	)	PUNCT
admet-373	205	38	14	14	NUM
admet-373	205	39	-	-	SYM
admet-373	205	40	38	38	NUM
admet-373	205	41	26	26	NUM
admet-373	205	42	it	it	PRON
admet-373	205	43	is	be	AUX
admet-373	205	44	interesting	interesting	ADJ
admet-373	205	45	to	to	PART
admet-373	205	46	observe	observe	VERB
admet-373	205	47	that	that	SCONJ
admet-373	205	48	the	the	DET
admet-373	205	49	estimated	estimate	VERB
admet-373	205	50	demax	demax	NOUN
admet-373	205	51	of	of	ADP
admet-373	205	52	the	the	DET
admet-373	205	53	marketed	market	VERB
admet-373	205	54	drugs	drug	NOUN
admet-373	205	55	is	be	AUX
admet-373	205	56	typically	typically	ADV
admet-373	205	57	1	1	NUM
admet-373	205	58	%	%	NOUN
admet-373	205	59	or	or	CCONJ
admet-373	205	60	just	just	ADV
admet-373	205	61	above	above	ADV
admet-373	205	62	.	.	PUNCT
admet-373	206	1	this	this	PRON
admet-373	206	2	also	also	ADV
admet-373	206	3	means	mean	VERB
admet-373	206	4	that	that	SCONJ
admet-373	206	5	the	the	DET
admet-373	206	6	unbound	unbound	NOUN
admet-373	206	7	volume	volume	NOUN
admet-373	206	8	of	of	ADP
admet-373	206	9	distribution	distribution	NOUN
admet-373	206	10	of	of	ADP
admet-373	206	11	marketed	market	VERB
admet-373	206	12	drugs	drug	NOUN
admet-373	206	13	is	be	AUX
admet-373	206	14	typically	typically	ADV
admet-373	206	15	less	less	ADJ
admet-373	206	16	than	than	ADP
admet-373	206	17	100	100	NUM
admet-373	206	18	l	l	NOUN
admet-373	206	19	/	/	SYM
admet-373	206	20	kg	kg	PROPN
admet-373	206	21	.	.	PUNCT
admet-373	207	1	thus	thus	ADV
admet-373	207	2	,	,	PUNCT
admet-373	207	3	when	when	SCONJ
admet-373	207	4	we	we	PRON
admet-373	207	5	plot	plot	VERB
admet-373	207	6	the	the	DET
admet-373	207	7	potency	potency	NOUN
admet-373	207	8	(	(	PUNCT
admet-373	207	9	pic50	pic50	NOUN
admet-373	207	10	)	)	PUNCT
admet-373	207	11	values	value	NOUN
admet-373	207	12	in	in	ADP
admet-373	207	13	the	the	DET
admet-373	207	14	function	function	NOUN
admet-373	207	15	of	of	ADP
admet-373	207	16	the	the	DET
admet-373	207	17	drug	drug	NOUN
admet-373	207	18	efficiency	efficiency	NOUN
admet-373	207	19	index	index	NOUN
admet-373	207	20	(	(	PUNCT
admet-373	207	21	dei	dei	NOUN
admet-373	207	22	)	)	PUNCT
admet-373	207	23	,	,	PUNCT
admet-373	207	24	which	which	PRON
admet-373	207	25	is	be	AUX
admet-373	207	26	the	the	DET
admet-373	207	27	sum	sum	NOUN
admet-373	207	28	of	of	ADP
admet-373	207	29	the	the	DET
admet-373	207	30	pic50	pic50	NOUN
admet-373	207	31	and	and	CCONJ
admet-373	207	32	the	the	DET
admet-373	207	33	log	log	NOUN
admet-373	207	34	de	de	PROPN
admet-373	207	35	,	,	PUNCT
admet-373	207	36	the	the	DET
admet-373	207	37	marketed	market	VERB
admet-373	207	38	drugs	drug	NOUN
admet-373	207	39	are	be	AUX
admet-373	207	40	around	around	ADP
admet-373	207	41	the	the	DET
admet-373	207	42	line	line	NOUN
admet-373	207	43	of	of	ADP
admet-373	207	44	unity	unity	NOUN
admet-373	207	45	(	(	PUNCT
admet-373	207	46	see	see	VERB
admet-373	207	47	figure	figure	NOUN
admet-373	207	48	7	7	NUM
admet-373	207	49	)	)	PUNCT
admet-373	207	50	.	.	PUNCT
admet-373	208	1	it	it	PRON
admet-373	208	2	has	have	AUX
admet-373	208	3	been	be	AUX
admet-373	208	4	observed	observe	VERB
admet-373	208	5	[	[	X
admet-373	208	6	51	51	NUM
admet-373	208	7	]	]	PUNCT
admet-373	208	8	that	that	PRON
admet-373	208	9	discovery	discovery	NOUN
admet-373	208	10	compounds	compound	NOUN
admet-373	208	11	usually	usually	ADV
admet-373	208	12	have	have	VERB
admet-373	208	13	very	very	ADV
admet-373	208	14	narrow	narrow	ADJ
admet-373	208	15	potency	potency	NOUN
admet-373	208	16	range	range	NOUN
admet-373	208	17	(	(	PUNCT
admet-373	208	18	pic50	pic50	NOUN
admet-373	208	19	between	between	ADP
admet-373	208	20	7	7	NUM
admet-373	208	21	to	to	ADP
admet-373	208	22	9	9	NUM
admet-373	208	23	)	)	PUNCT
admet-373	208	24	,	,	PUNCT
admet-373	208	25	but	but	CCONJ
admet-373	208	26	a	a	DET
admet-373	208	27	much	much	ADV
admet-373	208	28	broader	broad	ADJ
admet-373	208	29	range	range	NOUN
admet-373	208	30	of	of	ADP
admet-373	208	31	drug	drug	NOUN
admet-373	208	32	efficiency	efficiency	NOUN
admet-373	208	33	index	index	NOUN
admet-373	208	34	.	.	PUNCT
admet-373	209	1	based	base	VERB
admet-373	209	2	on	on	ADP
admet-373	209	3	the	the	DET
admet-373	209	4	retrospective	retrospective	ADJ
admet-373	209	5	analysis	analysis	NOUN
admet-373	209	6	it	it	PRON
admet-373	209	7	turned	turn	VERB
admet-373	209	8	out	out	ADP
admet-373	209	9	that	that	SCONJ
admet-373	209	10	compounds	compound	VERB
admet-373	209	11	that	that	PRON
admet-373	209	12	are	be	AUX
admet-373	209	13	on	on	ADP
admet-373	209	14	the	the	DET
admet-373	209	15	right	right	ADJ
admet-373	209	16	side	side	NOUN
admet-373	209	17	of	of	ADP
admet-373	209	18	the	the	DET
admet-373	209	19	line	line	NOUN
admet-373	209	20	of	of	ADP
admet-373	209	21	unity	unity	NOUN
admet-373	209	22	survived	survive	VERB
admet-373	209	23	the	the	DET
admet-373	209	24	strict	strict	ADJ
admet-373	209	25	candidate	candidate	NOUN
admet-373	209	26	selection	selection	NOUN
admet-373	209	27	procedure	procedure	NOUN
admet-373	209	28	and	and	CCONJ
admet-373	209	29	showed	show	VERB
admet-373	209	30	a	a	DET
admet-373	209	31	good	good	ADJ
admet-373	209	32	pk	pk	NOUN
admet-373	209	33	/	/	SYM
admet-373	209	34	pd	pd	NOUN
admet-373	209	35	profile	profile	NOUN
admet-373	210	1	[	[	X
admet-373	210	2	51	51	NUM
admet-373	210	3	]	]	PUNCT
admet-373	210	4	.	.	PUNCT
admet-373	211	1	figure	figure	NOUN
admet-373	211	2	7	7	NUM
admet-373	211	3	.	.	PUNCT
admet-373	212	1	the	the	DET
admet-373	212	2	plot	plot	NOUN
admet-373	212	3	of	of	ADP
admet-373	212	4	potency	potency	NOUN
admet-373	212	5	in	in	ADP
admet-373	212	6	the	the	DET
admet-373	212	7	function	function	NOUN
admet-373	212	8	of	of	ADP
admet-373	212	9	dei	dei	PROPN
admet-373	212	10	.	.	PUNCT
admet-373	213	1	the	the	DET
admet-373	213	2	line	line	NOUN
admet-373	213	3	of	of	ADP
admet-373	213	4	unity	unity	NOUN
admet-373	213	5	represents	represent	VERB
admet-373	213	6	when	when	SCONJ
admet-373	213	7	the	the	DET
admet-373	213	8	drug	drug	NOUN
admet-373	213	9	efficiency	efficiency	NOUN
admet-373	213	10	de=1	de=1	X
admet-373	213	11	%	%	NOUN
admet-373	213	12	.	.	PUNCT
admet-373	214	1	the	the	DET
admet-373	214	2	logarithm	logarithm	NOUN
admet-373	214	3	of	of	ADP
admet-373	214	4	1	1	NUM
admet-373	214	5	is	be	AUX
admet-373	214	6	zero	zero	NUM
admet-373	214	7	,	,	PUNCT
admet-373	214	8	thus	thus	ADV
admet-373	214	9	,	,	PUNCT
admet-373	214	10	dei	dei	NOUN
admet-373	214	11	=	=	SYM
admet-373	214	12	pic50	pic50	NOUN
admet-373	214	13	.	.	PUNCT
admet-373	215	1	the	the	DET
admet-373	215	2	yellow	yellow	ADJ
admet-373	215	3	squares	square	NOUN
admet-373	215	4	show	show	VERB
admet-373	215	5	project	project	NOUN
admet-373	215	6	compounds	compound	VERB
admet-373	215	7	[	[	X
admet-373	215	8	51	51	NUM
admet-373	215	9	]	]	PUNCT
admet-373	215	10	,	,	PUNCT
admet-373	215	11	having	have	VERB
admet-373	215	12	the	the	DET
admet-373	215	13	same	same	ADJ
admet-373	215	14	good	good	ADJ
admet-373	215	15	potency	potency	NOUN
admet-373	215	16	but	but	CCONJ
admet-373	215	17	a	a	DET
admet-373	215	18	range	range	NOUN
admet-373	215	19	of	of	ADP
admet-373	215	20	dei	dei	NOUN
admet-373	215	21	.	.	PUNCT
admet-373	216	1	the	the	DET
admet-373	216	2	candidate	candidate	NOUN
admet-373	216	3	molecules	molecule	NOUN
admet-373	216	4	(	(	PUNCT
admet-373	216	5	red	red	ADJ
admet-373	216	6	stars	star	NOUN
admet-373	216	7	)	)	PUNCT
admet-373	216	8	are	be	AUX
admet-373	216	9	on	on	ADP
admet-373	216	10	the	the	DET
admet-373	216	11	right	right	ADJ
admet-373	216	12	-	-	PUNCT
admet-373	216	13	hand	hand	NOUN
admet-373	216	14	side	side	NOUN
admet-373	216	15	of	of	ADP
admet-373	216	16	the	the	DET
admet-373	216	17	line	line	NOUN
admet-373	216	18	where	where	SCONJ
admet-373	216	19	most	most	ADJ
admet-373	216	20	of	of	ADP
admet-373	216	21	the	the	DET
admet-373	216	22	marketed	market	VERB
admet-373	216	23	drugs	drug	NOUN
admet-373	216	24	are	be	AUX
admet-373	216	25	.	.	PUNCT
admet-373	217	1	it	it	PRON
admet-373	217	2	is	be	AUX
admet-373	217	3	interesting	interesting	ADJ
admet-373	217	4	to	to	PART
admet-373	217	5	note	note	VERB
admet-373	217	6	that	that	SCONJ
admet-373	217	7	we	we	PRON
admet-373	217	8	could	could	AUX
admet-373	217	9	not	not	PART
admet-373	217	10	find	find	VERB
admet-373	217	11	any	any	DET
admet-373	217	12	marketed	market	VERB
admet-373	217	13	drugs	drug	NOUN
admet-373	217	14	with	with	ADP
admet-373	217	15	drug	drug	NOUN
admet-373	217	16	efficiencies	efficiency	NOUN
admet-373	217	17	higher	high	ADJ
admet-373	217	18	than	than	ADP
admet-373	217	19	1015	1015	NUM
admet-373	217	20	%	%	NOUN
admet-373	217	21	.	.	PUNCT
admet-373	218	1	this	this	PRON
admet-373	218	2	suggests	suggest	VERB
admet-373	218	3	that	that	SCONJ
admet-373	218	4	there	there	PRON
admet-373	218	5	should	should	AUX
admet-373	218	6	be	be	AUX
admet-373	218	7	an	an	DET
admet-373	218	8	optimum	optimum	ADJ
admet-373	218	9	proportion	proportion	NOUN
admet-373	218	10	of	of	ADP
admet-373	218	11	the	the	DET
admet-373	218	12	dose	dose	NOUN
admet-373	218	13	and	and	CCONJ
admet-373	218	14	free	free	ADJ
admet-373	218	15	bio	bio	NOUN
admet-373	218	16	-	-	ADJ
admet-373	218	17	phase	phase	NOUN
admet-373	218	18	concentration	concentration	NOUN
admet-373	218	19	that	that	PRON
admet-373	218	20	is	be	AUX
admet-373	218	21	less	less	ADJ
admet-373	218	22	than	than	ADP
admet-373	218	23	10	10	NUM
admet-373	218	24	-	-	SYM
admet-373	218	25	15	15	NUM
admet-373	218	26	%	%	NOUN
admet-373	218	27	drug	drug	NOUN
admet-373	218	28	efficiency	efficiency	NOUN
admet-373	218	29	.	.	PUNCT
admet-373	219	1	it	it	PRON
admet-373	219	2	is	be	AUX
admet-373	219	3	very	very	ADV
admet-373	219	4	likely	likely	ADJ
admet-373	219	5	,	,	PUNCT
admet-373	219	6	that	that	SCONJ
admet-373	219	7	when	when	SCONJ
admet-373	219	8	the	the	DET
admet-373	219	9	high	high	ADJ
admet-373	219	10	proportion	proportion	NOUN
admet-373	219	11	of	of	ADP
admet-373	219	12	the	the	DET
admet-373	219	13	administered	administer	VERB
admet-373	219	14	amount	amount	NOUN
admet-373	219	15	of	of	ADP
admet-373	219	16	compound	compound	NOUN
admet-373	219	17	is	be	AUX
admet-373	219	18	free	free	ADJ
admet-373	219	19	then	then	ADV
admet-373	219	20	the	the	DET
admet-373	219	21	elimination	elimination	NOUN
admet-373	219	22	rate	rate	NOUN
admet-373	219	23	/	/	SYM
admet-373	219	24	clearance	clearance	NOUN
admet-373	219	25	will	will	AUX
admet-373	219	26	be	be	AUX
admet-373	219	27	high	high	ADJ
admet-373	219	28	and	and	CCONJ
admet-373	219	29	the	the	DET
admet-373	219	30	various	various	ADJ
admet-373	219	31	total	total	ADJ
admet-373	219	32	tissue	tissue	NOUN
admet-373	219	33	concentrations	concentration	NOUN
admet-373	219	34	may	may	AUX
admet-373	219	35	be	be	AUX
admet-373	219	36	low	low	ADJ
admet-373	219	37	.	.	PUNCT
admet-373	220	1	therefore	therefore	ADV
admet-373	220	2	,	,	PUNCT
admet-373	220	3	we	we	PRON
admet-373	220	4	can	can	AUX
admet-373	220	5	optimise	optimise	VERB
admet-373	220	6	drug	drug	NOUN
admet-373	220	7	discovery	discovery	NOUN
admet-373	220	8	compounds	compound	NOUN
admet-373	220	9	and	and	CCONJ
admet-373	220	10	triage	triage	VERB
admet-373	220	11	them	they	PRON
admet-373	220	12	to	to	PART
admet-373	220	13	have	have	VERB
admet-373	220	14	reasonably	reasonably	ADV
admet-373	220	15	good	good	ADJ
admet-373	220	16	potency	potency	NOUN
admet-373	220	17	if	if	SCONJ
admet-373	220	18	the	the	DET
admet-373	220	19	drug	drug	NOUN
admet-373	220	20	efficiency	efficiency	NOUN
admet-373	220	21	is	be	AUX
admet-373	220	22	approximately	approximately	ADV
admet-373	220	23	1	1	NUM
admet-373	220	24	to	to	PART
admet-373	220	25	5	5	NUM
admet-373	220	26	%	%	NOUN
admet-373	220	27	.	.	PUNCT
admet-373	221	1	the	the	DET
admet-373	221	2	regis	regis	PROPN
admet-373	221	3	iam	iam	PROPN
admet-373	221	4	mb	mb	PROPN
admet-373	221	5	/	/	SYM
admet-373	221	6	pb	pb	ADP
admet-373	221	7	technology	technology	NOUN
admet-373	221	8	®	®	NOUN
admet-373	221	9	that	that	PRON
admet-373	221	10	use	use	VERB
admet-373	221	11	biomimetic	biomimetic	ADJ
admet-373	221	12	hplc	hplc	NOUN
admet-373	221	13	stationary	stationary	ADJ
admet-373	221	14	phases	phase	NOUN
admet-373	221	15	to	to	PART
admet-373	221	16	measure	measure	VERB
admet-373	221	17	the	the	DET
admet-373	221	18	dynamic	dynamic	ADJ
admet-373	221	19	equilibrium	equilibrium	NOUN
admet-373	221	20	constants	constant	NOUN
admet-373	221	21	of	of	ADP
admet-373	221	22	the	the	DET
admet-373	221	23	compounds	compound	NOUN
admet-373	221	24	with	with	ADP
admet-373	221	25	the	the	DET
admet-373	221	26	major	major	ADJ
admet-373	221	27	binding	bind	VERB
admet-373	221	28	components	component	NOUN
admet-373	221	29	of	of	ADP
admet-373	221	30	the	the	DET
admet-373	221	31	body	body	NOUN
admet-373	221	32	enables	enable	VERB
admet-373	221	33	the	the	DET
admet-373	221	34	estimation	estimation	NOUN
admet-373	221	35	of	of	ADP
admet-373	221	36	volume	volume	NOUN
admet-373	221	37	distribution	distribution	NOUN
admet-373	221	38	and	and	CCONJ
admet-373	221	39	unbound	unbound	NOUN
admet-373	221	40	volume	volume	NOUN
admet-373	221	41	of	of	ADP
admet-373	221	42	distribution	distribution	NOUN
admet-373	221	43	without	without	ADP
admet-373	221	44	using	use	VERB
admet-373	221	45	in	in	ADP
admet-373	221	46	vivo	vivo	ADJ
admet-373	221	47	experimentation	experimentation	NOUN
admet-373	221	48	for	for	ADP
admet-373	221	49	the	the	DET
admet-373	221	50	fraction	fraction	NOUN
admet-373	221	51	of	of	ADP
admet-373	221	52	the	the	DET
admet-373	221	53	cost	cost	NOUN
admet-373	221	54	and	and	CCONJ
admet-373	221	55	time	time	NOUN
admet-373	221	56	.	.	PUNCT
admet-373	222	1	it	it	PRON
admet-373	222	2	is	be	AUX
admet-373	222	3	also	also	ADV
admet-373	222	4	interesting	interesting	ADJ
admet-373	222	5	to	to	PART
admet-373	222	6	note	note	VERB
admet-373	222	7	that	that	SCONJ
admet-373	222	8	the	the	DET
admet-373	222	9	demax	demax	NOUN
admet-373	222	10	values	value	NOUN
admet-373	222	11	representing	represent	VERB
admet-373	222	12	the	the	DET
admet-373	222	13	sum	sum	NOUN
admet-373	222	14	of	of	ADP
admet-373	222	15	the	the	DET
admet-373	222	16	albumin	albumin	NOUN
admet-373	222	17	and	and	CCONJ
admet-373	222	18	phospholipid	phospholipid	NOUN
admet-373	222	19	binding	binding	NOUN
admet-373	222	20	showed	show	VERB
admet-373	222	21	very	very	ADV
admet-373	222	22	good	good	ADJ
admet-373	222	23	inverse	inverse	NOUN
admet-373	222	24	correlation	correlation	NOUN
admet-373	222	25	with	with	ADP
admet-373	222	26	clogp	clogp	NOUN
admet-373	222	27	(	(	PUNCT
admet-373	222	28	much	much	ADV
admet-373	222	29	better	well	ADJ
admet-373	222	30	than	than	ADP
admet-373	222	31	with	with	ADP
admet-373	222	32	clogd	clogd	NOUN
admet-373	222	33	)	)	PUNCT
admet-373	223	1	[	[	X
admet-373	223	2	51	51	NUM
admet-373	223	3	]	]	PUNCT
admet-373	223	4	.	.	PUNCT
admet-373	224	1	this	this	PRON
admet-373	224	2	is	be	AUX
admet-373	224	3	because	because	SCONJ
admet-373	224	4	the	the	DET
admet-373	224	5	log	log	NOUN
admet-373	224	6	d	d	NOUN
admet-373	224	7	drops	drop	VERB
admet-373	224	8	whatever	whatever	DET
admet-373	224	9	charge	charge	NOUN
admet-373	224	10	is	be	AUX
admet-373	224	11	present	present	ADJ
admet-373	224	12	on	on	ADP
admet-373	224	13	the	the	DET
admet-373	224	14	molecule	molecule	NOUN
admet-373	224	15	at	at	ADP
admet-373	224	16	ph	ph	PROPN
admet-373	224	17	7.4	7.4	NUM
admet-373	224	18	,	,	PUNCT
admet-373	224	19	however	however	ADV
admet-373	224	20	the	the	DET
admet-373	224	21	sum	sum	NOUN
admet-373	224	22	of	of	ADP
admet-373	224	23	albumin	albumin	NOUN
admet-373	224	24	and	and	CCONJ
admet-373	224	25	phospholipid	phospholipid	NOUN
admet-373	224	26	binding	bind	VERB
admet-373	224	27	change	change	NOUN
admet-373	224	28	very	very	ADV
admet-373	224	29	little	little	ADJ
admet-373	224	30	with	with	ADP
admet-373	224	31	the	the	DET
admet-373	224	32	presence	presence	NOUN
admet-373	224	33	of	of	ADP
admet-373	224	34	charge	charge	NOUN
admet-373	224	35	.	.	PUNCT
admet-373	225	1	it	it	PRON
admet-373	225	2	is	be	AUX
admet-373	225	3	because	because	SCONJ
admet-373	225	4	positively	positively	ADV
admet-373	225	5	charged	charge	VERB
admet-373	225	6	compounds	compound	NOUN
admet-373	225	7	bind	bind	VERB
admet-373	225	8	more	more	ADV
admet-373	225	9	strongly	strongly	ADV
admet-373	225	10	to	to	ADP
admet-373	225	11	iam	iam	PROPN
admet-373	225	12	(	(	PUNCT
admet-373	225	13	phospholipids	phospholipid	NOUN
admet-373	225	14	)	)	PUNCT
admet-373	225	15	while	while	SCONJ
admet-373	225	16	negatively	negatively	ADV
admet-373	225	17	charged	charge	VERB
admet-373	225	18	compounds	compound	NOUN
admet-373	225	19	have	have	VERB
admet-373	225	20	admet	admet	NOUN
admet-373	225	21	&	&	CCONJ
admet-373	225	22	dmpk	dmpk	PROPN
admet-373	225	23	5(1	5(1	NUM
admet-373	225	24	)	)	PUNCT
admet-373	225	25	(	(	PUNCT
admet-373	225	26	2017	2017	NUM
admet-373	225	27	)	)	PUNCT
admet-373	225	28	14	14	NUM
admet-373	225	29	-	-	SYM
admet-373	225	30	38	38	NUM
admet-373	225	31	in	in	ADP
admet-373	225	32	vitro	vitro	X
admet-373	225	33	membrane	membrane	NOUN
admet-373	225	34	and	and	CCONJ
admet-373	225	35	protein	protein	NOUN
admet-373	225	36	binding	bind	VERB
admet-373	225	37	doi	doi	NOUN
admet-373	225	38	:	:	PUNCT
admet-373	225	39	10.5599	10.5599	NUM
admet-373	225	40	/	/	SYM
admet-373	225	41	admet.5.1.373	admet.5.1.373	ADP
admet-373	225	42	27	27	NUM
admet-373	225	43	a	a	DET
admet-373	225	44	stronger	strong	ADJ
admet-373	225	45	affinity	affinity	NOUN
admet-373	225	46	to	to	ADP
admet-373	225	47	albumin	albumin	ADJ
admet-373	225	48	type	type	NOUN
admet-373	225	49	of	of	ADP
admet-373	225	50	proteins	protein	NOUN
admet-373	225	51	.	.	PUNCT
admet-373	226	1	that	that	PRON
admet-373	226	2	is	be	AUX
admet-373	226	3	why	why	SCONJ
admet-373	226	4	log	log	VERB
admet-373	226	5	p	p	NOUN
admet-373	226	6	is	be	AUX
admet-373	226	7	a	a	DET
admet-373	226	8	better	well	ADJ
admet-373	226	9	model	model	NOUN
admet-373	226	10	to	to	PART
admet-373	226	11	use	use	VERB
admet-373	226	12	than	than	ADP
admet-373	226	13	log	log	NOUN
admet-373	226	14	d	d	PROPN
admet-373	227	1	[	[	X
admet-373	227	2	51	51	NUM
admet-373	227	3	]	]	PUNCT
admet-373	227	4	.	.	PUNCT
admet-373	228	1	therefore	therefore	ADV
admet-373	228	2	,	,	PUNCT
admet-373	228	3	there	there	PRON
admet-373	228	4	is	be	VERB
admet-373	228	5	a	a	DET
admet-373	228	6	connection	connection	NOUN
admet-373	228	7	between	between	ADP
admet-373	228	8	dei	dei	NOUN
admet-373	228	9	and	and	CCONJ
admet-373	228	10	lle	lle	PROPN
admet-373	228	11	.	.	PUNCT
admet-373	229	1	demax	demax	PROPN
admet-373	229	2	determined	determine	VERB
admet-373	229	3	by	by	ADP
admet-373	229	4	the	the	DET
admet-373	229	5	iam	iam	PROPN
admet-373	229	6	mb	mb	PROPN
admet-373	229	7	/	/	SYM
admet-373	229	8	pb	pb	PRON
admet-373	229	9	technology	technology	NOUN
admet-373	229	10	is	be	AUX
admet-373	229	11	a	a	DET
admet-373	229	12	better	well	ADJ
admet-373	229	13	representation	representation	NOUN
admet-373	229	14	of	of	ADP
admet-373	229	15	the	the	DET
admet-373	229	16	nonspecific	nonspecific	ADJ
admet-373	229	17	binding	binding	NOUN
admet-373	229	18	of	of	ADP
admet-373	229	19	the	the	DET
admet-373	229	20	compounds	compound	NOUN
admet-373	229	21	than	than	ADP
admet-373	229	22	log	log	VERB
admet-373	229	23	p	p	NOUN
admet-373	229	24	as	as	SCONJ
admet-373	229	25	it	it	PRON
admet-373	229	26	is	be	AUX
admet-373	229	27	based	base	VERB
admet-373	229	28	on	on	ADP
admet-373	229	29	real	real	ADJ
admet-373	229	30	albumin	albumin	NOUN
admet-373	229	31	and	and	CCONJ
admet-373	229	32	iam	iam	PROPN
admet-373	229	33	affinity	affinity	NOUN
admet-373	229	34	of	of	ADP
admet-373	229	35	the	the	DET
admet-373	229	36	compounds	compound	NOUN
admet-373	229	37	.	.	PUNCT
admet-373	230	1	in	in	ADP
admet-373	230	2	our	our	PRON
admet-373	230	3	earlier	early	ADJ
admet-373	230	4	paper	paper	NOUN
admet-373	230	5	,	,	PUNCT
admet-373	230	6	we	we	PRON
admet-373	230	7	have	have	AUX
admet-373	230	8	shown	show	VERB
admet-373	230	9	that	that	SCONJ
admet-373	230	10	iam	iam	PROPN
admet-373	230	11	mb	mb	PROPN
admet-373	230	12	/	/	SYM
admet-373	230	13	pb	pb	NOUN
admet-373	230	14	deimax	deimax	NOUN
admet-373	230	15	showed	show	VERB
admet-373	230	16	a	a	DET
admet-373	230	17	better	well	ADJ
admet-373	230	18	correlation	correlation	NOUN
admet-373	230	19	with	with	ADP
admet-373	230	20	in	in	ADP
admet-373	230	21	vivo	vivo	NOUN
admet-373	230	22	log	log	NOUN
admet-373	230	23	deimax	deimax	NOUN
admet-373	230	24	than	than	ADP
admet-373	230	25	lle	lle	PROPN
admet-373	230	26	as	as	SCONJ
admet-373	230	27	it	it	PRON
admet-373	230	28	shown	show	VERB
admet-373	230	29	in	in	ADP
admet-373	230	30	figure	figure	NOUN
admet-373	230	31	8a	8a	NUM
admet-373	230	32	and	and	CCONJ
admet-373	230	33	8b	8b	NUM
admet-373	230	34	.	.	PUNCT
admet-373	231	1	figure	figure	NOUN
admet-373	231	2	8	8	NUM
admet-373	231	3	.	.	PUNCT
admet-373	231	4	comparison	comparison	NOUN
admet-373	231	5	of	of	ADP
admet-373	231	6	the	the	DET
admet-373	231	7	relationship	relationship	NOUN
admet-373	231	8	between	between	ADP
admet-373	231	9	in	in	ADP
admet-373	231	10	vivo	vivo	ADJ
admet-373	231	11	log	log	NOUN
admet-373	231	12	deimax	deimax	PROPN
admet-373	231	13	vs	vs	ADP
admet-373	231	14	lle	lle	PROPN
admet-373	231	15	(	(	PUNCT
admet-373	231	16	a	a	NOUN
admet-373	231	17	)	)	PUNCT
admet-373	231	18	and	and	CCONJ
admet-373	231	19	iam	iam	PROPN
admet-373	231	20	mb	mb	PROPN
admet-373	231	21	/	/	SYM
admet-373	231	22	pb	pb	X
admet-373	231	23	log	log	NOUN
admet-373	231	24	deimax	deimax	PROPN
admet-373	231	25	(	(	PUNCT
admet-373	231	26	b	b	NOUN
admet-373	231	27	)	)	PUNCT
admet-373	231	28	,	,	PUNCT
admet-373	231	29	respectively	respectively	ADV
admet-373	231	30	based	base	VERB
admet-373	231	31	on	on	ADP
admet-373	231	32	the	the	DET
admet-373	231	33	analysis	analysis	NOUN
admet-373	231	34	in	in	ADP
admet-373	231	35	reference	reference	NOUN
admet-373	231	36	[	[	X
admet-373	231	37	51	51	NUM
admet-373	231	38	]	]	PUNCT
admet-373	231	39	.	.	PUNCT
admet-373	232	1	the	the	DET
admet-373	232	2	better	well	ADJ
admet-373	232	3	fit	fit	NOUN
admet-373	232	4	is	be	AUX
admet-373	232	5	not	not	PART
admet-373	232	6	surprising	surprising	ADJ
admet-373	232	7	,	,	PUNCT
admet-373	232	8	as	as	SCONJ
admet-373	232	9	log	log	NOUN
admet-373	232	10	p	p	NOUN
admet-373	232	11	was	be	AUX
admet-373	232	12	intended	intend	VERB
admet-373	232	13	to	to	PART
admet-373	232	14	model	model	VERB
admet-373	232	15	the	the	DET
admet-373	232	16	non	non	ADJ
admet-373	232	17	-	-	ADJ
admet-373	232	18	specific	specific	ADJ
admet-373	232	19	binding	binding	NOUN
admet-373	232	20	in	in	ADP
admet-373	232	21	the	the	DET
admet-373	232	22	body	body	NOUN
admet-373	232	23	caused	cause	VERB
admet-373	232	24	by	by	ADP
admet-373	232	25	lipophilicity	lipophilicity	NOUN
admet-373	232	26	of	of	ADP
admet-373	232	27	the	the	DET
admet-373	232	28	compounds	compound	NOUN
admet-373	232	29	.	.	PUNCT
admet-373	233	1	the	the	DET
admet-373	233	2	iam	iam	PROPN
admet-373	233	3	mb	mb	PROPN
admet-373	233	4	/	/	SYM
admet-373	233	5	pb	pb	PRON
admet-373	233	6	technology	technology	NOUN
admet-373	233	7	provides	provide	VERB
admet-373	233	8	the	the	DET
admet-373	233	9	direct	direct	ADJ
admet-373	233	10	measurements	measurement	NOUN
admet-373	233	11	of	of	ADP
admet-373	233	12	the	the	DET
admet-373	233	13	major	major	ADJ
admet-373	233	14	types	type	NOUN
admet-373	233	15	of	of	ADP
admet-373	233	16	body	body	NOUN
admet-373	233	17	components	component	NOUN
admet-373	233	18	.	.	PUNCT
admet-373	234	1	though	though	SCONJ
admet-373	234	2	agp	agp	PROPN
admet-373	234	3	was	be	AUX
admet-373	234	4	not	not	PART
admet-373	234	5	used	use	VERB
admet-373	234	6	in	in	ADP
admet-373	234	7	the	the	DET
admet-373	234	8	models	model	NOUN
admet-373	234	9	described	describe	VERB
admet-373	234	10	above	above	ADV
admet-373	234	11	,	,	PUNCT
admet-373	234	12	it	it	PRON
admet-373	234	13	is	be	AUX
admet-373	234	14	mainly	mainly	ADV
admet-373	234	15	due	due	ADJ
admet-373	234	16	to	to	ADP
admet-373	234	17	statistical	statistical	ADJ
admet-373	234	18	reasons	reason	NOUN
admet-373	234	19	.	.	PUNCT
admet-373	235	1	the	the	DET
admet-373	235	2	agp	agp	NOUN
admet-373	235	3	binding	binding	NOUN
admet-373	235	4	and	and	CCONJ
admet-373	235	5	iam	iam	PROPN
admet-373	235	6	mb	mb	ADP
admet-373	235	7	binding	binding	PROPN
admet-373	235	8	showed	show	VERB
admet-373	235	9	a	a	DET
admet-373	235	10	significant	significant	ADJ
admet-373	235	11	correlation	correlation	NOUN
admet-373	235	12	,	,	PUNCT
admet-373	235	13	so	so	CCONJ
admet-373	235	14	it	it	PRON
admet-373	235	15	was	be	AUX
admet-373	235	16	not	not	PART
admet-373	235	17	possible	possible	ADJ
admet-373	235	18	to	to	PART
admet-373	235	19	use	use	VERB
admet-373	235	20	both	both	PRON
admet-373	235	21	as	as	ADP
admet-373	235	22	independent	independent	ADJ
admet-373	235	23	variables	variable	NOUN
admet-373	235	24	in	in	ADP
admet-373	235	25	the	the	DET
admet-373	235	26	regression	regression	NOUN
admet-373	235	27	equations	equation	NOUN
admet-373	235	28	.	.	PUNCT
admet-373	236	1	agp	agp	PROPN
admet-373	236	2	binds	bind	VERB
admet-373	236	3	also	also	ADV
admet-373	236	4	the	the	DET
admet-373	236	5	positively	positively	ADV
admet-373	236	6	charged	charge	VERB
admet-373	236	7	compounds	compound	NOUN
admet-373	236	8	,	,	PUNCT
admet-373	236	9	however	however	ADV
admet-373	236	10	,	,	PUNCT
admet-373	236	11	there	there	PRON
admet-373	236	12	is	be	VERB
admet-373	236	13	a	a	DET
admet-373	236	14	different	different	ADJ
admet-373	236	15	steric	steric	ADJ
admet-373	236	16	hindrance	hindrance	NOUN
admet-373	236	17	for	for	ADP
admet-373	236	18	molecules	molecule	NOUN
admet-373	236	19	that	that	PRON
admet-373	236	20	have	have	VERB
admet-373	236	21	bulky	bulky	ADJ
admet-373	236	22	substitutions	substitution	NOUN
admet-373	236	23	near	near	ADP
admet-373	236	24	the	the	DET
admet-373	236	25	positive	positive	ADJ
admet-373	236	26	charge	charge	NOUN
admet-373	236	27	[	[	X
admet-373	236	28	62	62	NUM
admet-373	236	29	]	]	PUNCT
admet-373	236	30	.	.	PUNCT
admet-373	237	1	although	although	SCONJ
admet-373	237	2	agp	agp	PROPN
admet-373	237	3	can	can	AUX
admet-373	237	4	be	be	AUX
admet-373	237	5	found	find	VERB
admet-373	237	6	in	in	ADP
admet-373	237	7	human	human	ADJ
admet-373	237	8	plasma	plasma	NOUN
admet-373	237	9	at	at	ADP
admet-373	237	10	low	low	ADJ
admet-373	237	11	concentrations	concentration	NOUN
admet-373	237	12	(	(	PUNCT
admet-373	237	13	approximately	approximately	ADV
admet-373	237	14	1.5	1.5	NUM
admet-373	237	15	%	%	NOUN
admet-373	237	16	)	)	PUNCT
admet-373	237	17	it	it	PRON
admet-373	237	18	may	may	AUX
admet-373	237	19	be	be	AUX
admet-373	237	20	significant	significant	ADJ
admet-373	237	21	in	in	ADP
admet-373	237	22	clinical	clinical	ADJ
admet-373	237	23	investigations	investigation	NOUN
admet-373	237	24	as	as	SCONJ
admet-373	237	25	its	its	PRON
admet-373	237	26	concentration	concentration	NOUN
admet-373	237	27	depends	depend	VERB
admet-373	237	28	on	on	ADP
admet-373	237	29	the	the	DET
admet-373	237	30	disease	disease	NOUN
admet-373	237	31	state	state	NOUN
admet-373	237	32	and	and	CCONJ
admet-373	237	33	can	can	AUX
admet-373	237	34	increase	increase	VERB
admet-373	237	35	significantly	significantly	ADV
admet-373	237	36	[	[	X
admet-373	237	37	63	63	NUM
admet-373	237	38	]	]	PUNCT
admet-373	237	39	.	.	PUNCT
admet-373	238	1	therefore	therefore	ADV
admet-373	238	2	compounds	compound	VERB
admet-373	238	3	’	'	PUNCT
admet-373	238	4	strong	strong	ADJ
admet-373	238	5	binding	bind	VERB
admet-373	238	6	to	to	ADP
admet-373	238	7	agp	agp	NOUN
admet-373	238	8	should	should	AUX
admet-373	238	9	be	be	AUX
admet-373	238	10	avoided	avoid	VERB
admet-373	238	11	as	as	SCONJ
admet-373	238	12	it	it	PRON
admet-373	238	13	may	may	AUX
admet-373	238	14	cause	cause	VERB
admet-373	238	15	variable	variable	ADJ
admet-373	238	16	free	free	ADJ
admet-373	238	17	concentrations	concentration	NOUN
admet-373	238	18	of	of	ADP
admet-373	238	19	the	the	DET
admet-373	238	20	drug	drug	NOUN
admet-373	238	21	in	in	ADP
admet-373	238	22	patients	patient	NOUN
admet-373	238	23	with	with	ADP
admet-373	238	24	various	various	ADJ
admet-373	238	25	diseases	disease	NOUN
admet-373	238	26	.	.	PUNCT
admet-373	239	1	the	the	DET
admet-373	239	2	model	model	NOUN
admet-373	239	3	to	to	PART
admet-373	239	4	estimate	estimate	VERB
admet-373	239	5	total	total	ADJ
admet-373	239	6	plasma	plasma	NOUN
admet-373	239	7	protein	protein	NOUN
admet-373	239	8	binding	bind	VERB
admet-373	239	9	(	(	PUNCT
admet-373	239	10	log	log	PROPN
admet-373	239	11	k(ppb	k(ppb	PROPN
admet-373	239	12	)	)	PUNCT
admet-373	239	13	)	)	PUNCT
admet-373	239	14	includes	include	VERB
admet-373	239	15	the	the	DET
admet-373	239	16	agp	agp	NOUN
admet-373	239	17	binding	binding	NOUN
admet-373	239	18	as	as	SCONJ
admet-373	239	19	is	be	AUX
admet-373	239	20	shown	show	VERB
admet-373	239	21	by	by	ADP
admet-373	239	22	equation	equation	NOUN
admet-373	239	23	8	8	NUM
admet-373	240	1	[	[	X
admet-373	240	2	64	64	NUM
admet-373	240	3	]	]	PUNCT
admet-373	240	4	.	.	PUNCT
admet-373	241	1	log	log	VERB
admet-373	241	2	𝑘	𝑘	PROPN
admet-373	241	3	(	(	PUNCT
admet-373	241	4	𝑃𝑃𝐵	𝑃𝑃𝐵	PROPN
admet-373	241	5	)	)	PUNCT
admet-373	241	6	=	=	SYM
admet-373	241	7	0.87	0.87	NUM
admet-373	241	8	∗	∗	NOUN
admet-373	241	9	log	log	NOUN
admet-373	241	10	𝑘(𝐻𝑆𝐴	𝑘(𝐻𝑆𝐴	PROPN
admet-373	241	11	)	)	PUNCT
admet-373	242	1	+	+	NUM
admet-373	242	2	0.17	0.17	NUM
admet-373	242	3	∗	∗	NOUN
admet-373	242	4	log	log	NOUN
admet-373	242	5	𝑘(𝐴𝐺𝑃	𝑘(𝐴𝐺𝑃	NOUN
admet-373	242	6	)	)	PUNCT
admet-373	243	1	+	+	CCONJ
admet-373	243	2	0.06	0.06	NUM
admet-373	243	3	∗	∗	NOUN
admet-373	243	4	𝑐𝑀𝑅	𝑐𝑀𝑅	CCONJ
admet-373	243	5	−	−	PROPN
admet-373	243	6	0.27	0.27	NUM
admet-373	243	7	(	(	PUNCT
admet-373	243	8	8)	8)	NUM
admet-373	243	9	n	n	NOUN
admet-373	243	10	=	=	SYM
admet-373	243	11	55	55	NUM
admet-373	243	12	r2	r2	NOUN
admet-373	243	13	=	=	SYM
admet-373	243	14	0.85	0.85	NUM
admet-373	243	15	s=0.36	s=0.36	NOUN
admet-373	243	16	cmr	cmr	NOUN
admet-373	243	17	is	be	AUX
admet-373	243	18	the	the	DET
admet-373	243	19	calculated	calculated	ADJ
admet-373	243	20	molar	molar	ADJ
admet-373	243	21	refraction	refraction	NOUN
admet-373	243	22	of	of	ADP
admet-373	243	23	the	the	DET
admet-373	243	24	compounds	compound	NOUN
admet-373	243	25	related	relate	VERB
admet-373	243	26	to	to	ADP
admet-373	243	27	the	the	DET
admet-373	243	28	size	size	NOUN
admet-373	243	29	of	of	ADP
admet-373	243	30	the	the	DET
admet-373	243	31	molecules	molecule	NOUN
admet-373	243	32	and	and	CCONJ
admet-373	243	33	accounts	account	NOUN
admet-373	243	34	for	for	ADP
admet-373	243	35	the	the	DET
admet-373	243	36	non	non	ADJ
admet-373	243	37	-	-	ADJ
admet-373	243	38	specific	specific	ADJ
admet-373	243	39	binding	binding	NOUN
admet-373	243	40	of	of	ADP
admet-373	243	41	the	the	DET
admet-373	243	42	compounds	compound	NOUN
admet-373	243	43	to	to	ADP
admet-373	243	44	immunoglobulins	immunoglobulin	NOUN
admet-373	243	45	in	in	ADP
admet-373	243	46	the	the	DET
admet-373	243	47	plasma	plasma	NOUN
admet-373	243	48	.	.	PUNCT
admet-373	244	1	agp	agp	PROPN
admet-373	244	2	also	also	ADV
admet-373	244	3	represents	represent	VERB
admet-373	244	4	important	important	ADJ
admet-373	244	5	cellular	cellular	ADJ
admet-373	244	6	components	component	NOUN
admet-373	244	7	such	such	ADJ
admet-373	244	8	as	as	ADP
admet-373	244	9	glycoprotein	glycoprotein	NOUN
admet-373	244	10	in	in	ADP
admet-373	244	11	general	general	ADJ
admet-373	244	12	.	.	PUNCT
admet-373	245	1	there	there	PRON
admet-373	245	2	has	have	AUX
admet-373	245	3	been	be	AUX
admet-373	245	4	observed	observe	VERB
admet-373	245	5	overlapping	overlap	VERB
admet-373	245	6	binding	bind	VERB
admet-373	245	7	between	between	ADP
admet-373	245	8	agp	agp	PROPN
admet-373	245	9	and	and	CCONJ
admet-373	245	10	p	p	NOUN
admet-373	245	11	-	-	PUNCT
admet-373	245	12	glycoprotein	glycoprotein	NOUN
admet-373	245	13	[	[	X
admet-373	245	14	65	65	NUM
admet-373	245	15	]	]	PUNCT
admet-373	245	16	.	.	PUNCT
admet-373	246	1	also	also	ADV
admet-373	246	2	,	,	PUNCT
admet-373	246	3	the	the	DET
admet-373	246	4	mucus	mucus	NOUN
admet-373	246	5	in	in	ADP
admet-373	246	6	human	human	ADJ
admet-373	246	7	airways	airways	PROPN
admet-373	246	8	is	be	AUX
admet-373	246	9	composed	compose	VERB
admet-373	246	10	predominantly	predominantly	ADV
admet-373	246	11	of	of	ADP
admet-373	246	12	glycoproteins	glycoprotein	NOUN
admet-373	246	13	.	.	PUNCT
admet-373	247	1	several	several	ADJ
admet-373	247	2	tissue	tissue	NOUN
admet-373	247	3	binding	bind	VERB
admet-373	247	4	models	model	NOUN
admet-373	247	5	include	include	VERB
admet-373	247	6	the	the	DET
admet-373	247	7	agp	agp	NOUN
admet-373	247	8	binding	binding	NOUN
admet-373	247	9	,	,	PUNCT
admet-373	247	10	such	such	ADJ
admet-373	247	11	as	as	ADP
admet-373	247	12	valko	valko	NOUN
admet-373	247	13	,	,	PUNCT
admet-373	247	14	teague	teague	NOUN
admet-373	247	15	and	and	CCONJ
admet-373	247	16	pidgeon	pidgeon	PROPN
admet-373	247	17	admet	admet	PROPN
admet-373	247	18	&	&	CCONJ
admet-373	247	19	dmpk	dmpk	PROPN
admet-373	247	20	5(1	5(1	NUM
admet-373	247	21	)	)	PUNCT
admet-373	247	22	(	(	PUNCT
admet-373	247	23	2017	2017	NUM
admet-373	247	24	)	)	PUNCT
admet-373	247	25	14	14	NUM
admet-373	247	26	-	-	SYM
admet-373	247	27	38	38	NUM
admet-373	247	28	28	28	NUM
admet-373	247	29	mucus	mucus	NOUN
admet-373	247	30	binding	binding	NOUN
admet-373	247	31	showed	show	VERB
admet-373	247	32	good	good	ADJ
admet-373	247	33	correlation	correlation	NOUN
admet-373	247	34	to	to	ADP
admet-373	247	35	agp	agp	PROPN
admet-373	247	36	binding	bind	VERB
admet-373	247	37	(	(	PUNCT
admet-373	247	38	r2	r2	PROPN
admet-373	247	39	=	=	PUNCT
admet-373	247	40	0.85	0.85	NUM
admet-373	247	41	)	)	PUNCT
admet-373	248	1	[	[	X
admet-373	248	2	66	66	NUM
admet-373	248	3	]	]	PUNCT
admet-373	248	4	and	and	CCONJ
admet-373	248	5	lung	lung	NOUN
admet-373	248	6	tissue	tissue	NOUN
admet-373	248	7	binding	binding	NOUN
admet-373	248	8	showed	show	VERB
admet-373	248	9	good	good	ADJ
admet-373	248	10	correlations	correlation	NOUN
admet-373	248	11	with	with	ADP
admet-373	248	12	the	the	DET
admet-373	248	13	weighted	weight	VERB
admet-373	248	14	sum	sum	NOUN
admet-373	248	15	of	of	ADP
admet-373	248	16	hsa	hsa	PROPN
admet-373	248	17	and	and	CCONJ
admet-373	248	18	agp	agp	NOUN
admet-373	248	19	bindings	binding	NOUN
admet-373	248	20	[	[	X
admet-373	248	21	67	67	NUM
admet-373	248	22	]	]	PUNCT
admet-373	248	23	.	.	PUNCT
admet-373	249	1	conclusions	conclusion	NOUN
admet-373	249	2	established	establish	VERB
admet-373	249	3	screening	screening	NOUN
admet-373	249	4	procedures	procedure	NOUN
admet-373	249	5	in	in	ADP
admet-373	249	6	pharmaceutical	pharmaceutical	ADJ
admet-373	249	7	drug	drug	NOUN
admet-373	249	8	discovery	discovery	NOUN
admet-373	249	9	companies	company	NOUN
admet-373	249	10	cause	cause	VERB
admet-373	249	11	significant	significant	ADJ
admet-373	249	12	delays	delay	NOUN
admet-373	249	13	in	in	ADP
admet-373	249	14	getting	get	VERB
admet-373	249	15	a	a	DET
admet-373	249	16	compound	compound	NOUN
admet-373	249	17	to	to	ADP
admet-373	249	18	market	market	NOUN
admet-373	249	19	.	.	PUNCT
admet-373	250	1	one	one	NUM
admet-373	250	2	reason	reason	NOUN
admet-373	250	3	is	be	AUX
admet-373	250	4	that	that	SCONJ
admet-373	250	5	the	the	DET
admet-373	250	6	initial	initial	ADJ
admet-373	250	7	discovery	discovery	NOUN
admet-373	250	8	phase	phase	NOUN
admet-373	250	9	typically	typically	ADV
admet-373	250	10	prioritises	prioritise	VERB
admet-373	250	11	optimising	optimise	VERB
admet-373	250	12	discovery	discovery	NOUN
admet-373	250	13	molecules	molecule	NOUN
admet-373	250	14	to	to	PART
admet-373	250	15	bind	bind	VERB
admet-373	250	16	with	with	ADP
admet-373	250	17	high	high	ADJ
admet-373	250	18	affinity	affinity	NOUN
admet-373	250	19	to	to	ADP
admet-373	250	20	the	the	DET
admet-373	250	21	target	target	NOUN
admet-373	250	22	receptor	receptor	NOUN
admet-373	250	23	.	.	PUNCT
admet-373	251	1	drug	drug	NOUN
admet-373	251	2	analogues	analogue	NOUN
admet-373	251	3	typically	typically	ADV
admet-373	251	4	possess	possess	VERB
admet-373	251	5	high	high	ADJ
admet-373	251	6	receptor	receptor	NOUN
admet-373	251	7	occupancy	occupancy	NOUN
admet-373	251	8	,	,	PUNCT
admet-373	251	9	which	which	PRON
admet-373	251	10	is	be	AUX
admet-373	251	11	anticipated	anticipate	VERB
admet-373	251	12	to	to	PART
admet-373	251	13	have	have	VERB
admet-373	251	14	better	well	ADJ
admet-373	251	15	efficacy	efficacy	NOUN
admet-373	251	16	and	and	CCONJ
admet-373	251	17	selectivity	selectivity	NOUN
admet-373	251	18	,	,	PUNCT
admet-373	251	19	i.e.	i.e.	X
admet-373	251	20	,	,	PUNCT
admet-373	251	21	reduced	reduce	VERB
admet-373	251	22	off	off	ADP
admet-373	251	23	-	-	PUNCT
admet-373	251	24	target	target	NOUN
admet-373	251	25	pharmacology	pharmacology	NOUN
admet-373	251	26	.	.	PUNCT
admet-373	252	1	the	the	DET
admet-373	252	2	insight	insight	NOUN
admet-373	252	3	lacking	lack	VERB
admet-373	252	4	during	during	ADP
admet-373	252	5	this	this	DET
admet-373	252	6	process	process	NOUN
admet-373	252	7	is	be	AUX
admet-373	252	8	that	that	SCONJ
admet-373	252	9	all	all	DET
admet-373	252	10	the	the	DET
admet-373	252	11	potent	potent	ADJ
admet-373	252	12	analogues	analogue	NOUN
admet-373	252	13	may	may	AUX
admet-373	252	14	not	not	PART
admet-373	252	15	have	have	VERB
admet-373	252	16	the	the	DET
admet-373	252	17	adme	adme	NOUN
admet-373	252	18	properties	property	NOUN
admet-373	252	19	to	to	PART
admet-373	252	20	elicit	elicit	VERB
admet-373	252	21	sufficient	sufficient	ADJ
admet-373	252	22	free	free	ADJ
admet-373	252	23	concentration	concentration	NOUN
admet-373	252	24	of	of	ADP
admet-373	252	25	the	the	DET
admet-373	252	26	drug	drug	NOUN
admet-373	252	27	near	near	ADP
admet-373	252	28	the	the	DET
admet-373	252	29	receptor	receptor	NOUN
admet-373	252	30	.	.	PUNCT
admet-373	253	1	we	we	PRON
admet-373	253	2	have	have	AUX
admet-373	253	3	presented	present	VERB
admet-373	253	4	an	an	DET
admet-373	253	5	hplc	hplc	NOUN
admet-373	253	6	based	base	VERB
admet-373	253	7	technology	technology	NOUN
admet-373	253	8	by	by	ADP
admet-373	253	9	which	which	PRON
admet-373	253	10	the	the	DET
admet-373	253	11	drug	drug	NOUN
admet-373	253	12	discovery	discovery	NOUN
admet-373	253	13	process	process	NOUN
admet-373	253	14	can	can	AUX
admet-373	253	15	be	be	AUX
admet-373	253	16	accelerated	accelerate	VERB
admet-373	253	17	by	by	ADP
admet-373	253	18	chromatographic	chromatographic	ADJ
admet-373	253	19	profiling	profiling	NOUN
admet-373	253	20	of	of	ADP
admet-373	253	21	the	the	DET
admet-373	253	22	analogues	analogue	NOUN
admet-373	253	23	to	to	PART
admet-373	253	24	model	model	VERB
admet-373	253	25	the	the	DET
admet-373	253	26	in	in	ADP
admet-373	253	27	vivo	vivo	ADJ
admet-373	253	28	drug	drug	NOUN
admet-373	253	29	disposition	disposition	NOUN
admet-373	253	30	.	.	PUNCT
admet-373	254	1	the	the	DET
admet-373	254	2	proposed	propose	VERB
admet-373	254	3	methodology	methodology	NOUN
admet-373	254	4	is	be	AUX
admet-373	254	5	able	able	ADJ
admet-373	254	6	to	to	PART
admet-373	254	7	identify	identify	VERB
admet-373	254	8	compounds	compound	NOUN
admet-373	254	9	that	that	PRON
admet-373	254	10	have	have	VERB
admet-373	254	11	a	a	DET
admet-373	254	12	greater	great	ADJ
admet-373	254	13	probability	probability	NOUN
admet-373	254	14	of	of	ADP
admet-373	254	15	having	have	VERB
admet-373	254	16	acceptable	acceptable	ADJ
admet-373	254	17	in	in	ADP
admet-373	254	18	vivo	vivo	ADJ
admet-373	254	19	properties	property	NOUN
admet-373	254	20	.	.	PUNCT
admet-373	255	1	the	the	DET
admet-373	255	2	methodology	methodology	NOUN
admet-373	255	3	has	have	AUX
admet-373	255	4	been	be	AUX
admet-373	255	5	compared	compare	VERB
admet-373	255	6	to	to	PART
admet-373	255	7	ligand	ligand	VERB
admet-373	255	8	lipophilicity	lipophilicity	NOUN
admet-373	255	9	efficiency	efficiency	NOUN
admet-373	255	10	(	(	PUNCT
admet-373	255	11	lle	lle	NOUN
admet-373	255	12	)	)	PUNCT
admet-373	255	13	parameter	parameter	NOUN
admet-373	255	14	that	that	PRON
admet-373	255	15	is	be	AUX
admet-373	255	16	used	use	VERB
admet-373	255	17	early	early	ADV
admet-373	255	18	in	in	ADP
admet-373	255	19	the	the	DET
admet-373	255	20	lead	lead	ADJ
admet-373	255	21	optimization	optimization	NOUN
admet-373	255	22	process	process	NOUN
admet-373	255	23	.	.	PUNCT
admet-373	256	1	there	there	PRON
admet-373	256	2	is	be	VERB
admet-373	256	3	an	an	DET
admet-373	256	4	inverse	inverse	ADJ
admet-373	256	5	correlation	correlation	NOUN
admet-373	256	6	between	between	ADP
admet-373	256	7	the	the	DET
admet-373	256	8	maximum	maximum	ADJ
admet-373	256	9	drug	drug	NOUN
admet-373	256	10	efficiency	efficiency	NOUN
admet-373	256	11	and	and	CCONJ
admet-373	256	12	clogp	clogp	ADJ
admet-373	256	13	,	,	PUNCT
admet-373	256	14	thus	thus	ADV
admet-373	256	15	lle	lle	NOUN
admet-373	256	16	incorporates	incorporate	VERB
admet-373	256	17	similar	similar	ADJ
admet-373	256	18	efficiency	efficiency	NOUN
admet-373	256	19	metrics	metric	NOUN
admet-373	256	20	as	as	ADP
admet-373	256	21	dei	dei	NOUN
admet-373	256	22	.	.	PUNCT
admet-373	257	1	while	while	SCONJ
admet-373	257	2	clogp	clogp	NOUN
admet-373	257	3	can	can	AUX
admet-373	257	4	be	be	AUX
admet-373	257	5	easily	easily	ADV
admet-373	257	6	calculated	calculate	VERB
admet-373	257	7	and	and	CCONJ
admet-373	257	8	the	the	DET
admet-373	257	9	drug	drug	NOUN
admet-373	257	10	efficiency	efficiency	NOUN
admet-373	257	11	requires	require	VERB
admet-373	257	12	simple	simple	ADJ
admet-373	257	13	hplc	hplc	NOUN
admet-373	257	14	based	base	VERB
admet-373	257	15	measurements	measurement	NOUN
admet-373	257	16	,	,	PUNCT
admet-373	257	17	the	the	DET
admet-373	257	18	advantage	advantage	NOUN
admet-373	257	19	is	be	AUX
admet-373	257	20	that	that	SCONJ
admet-373	257	21	it	it	PRON
admet-373	257	22	mimics	mimic	VERB
admet-373	257	23	the	the	DET
admet-373	257	24	biological	biological	ADJ
admet-373	257	25	non	non	ADJ
admet-373	257	26	-	-	ADJ
admet-373	257	27	specific	specific	ADJ
admet-373	257	28	binding	binding	NOUN
admet-373	257	29	more	more	ADV
admet-373	257	30	accurately	accurately	ADV
admet-373	257	31	than	than	ADP
admet-373	257	32	calculated	calculated	ADJ
admet-373	257	33	octanol	octanol	NOUN
admet-373	257	34	/	/	SYM
admet-373	257	35	water	water	NOUN
admet-373	257	36	lipophilicity	lipophilicity	NOUN
admet-373	257	37	.	.	PUNCT
admet-373	258	1	the	the	DET
admet-373	258	2	measured	measure	VERB
admet-373	258	3	iam	iam	PROPN
admet-373	258	4	mb	mb	NOUN
admet-373	258	5	/	/	SYM
admet-373	258	6	pb	pb	X
admet-373	258	7	incorporates	incorporate	VERB
admet-373	258	8	the	the	DET
admet-373	258	9	effect	effect	NOUN
admet-373	258	10	of	of	ADP
admet-373	258	11	charge	charge	NOUN
admet-373	258	12	and	and	CCONJ
admet-373	258	13	shape	shape	NOUN
admet-373	258	14	of	of	ADP
admet-373	258	15	the	the	DET
admet-373	258	16	molecules	molecule	NOUN
admet-373	258	17	on	on	ADP
admet-373	258	18	the	the	DET
admet-373	258	19	binding	binding	NOUN
admet-373	258	20	to	to	ADP
admet-373	258	21	real	real	ADJ
admet-373	258	22	body	body	NOUN
admet-373	258	23	components	component	NOUN
admet-373	258	24	which	which	PRON
admet-373	258	25	are	be	AUX
admet-373	258	26	not	not	PART
admet-373	258	27	reflected	reflect	VERB
admet-373	258	28	in	in	ADP
admet-373	258	29	their	their	PRON
admet-373	258	30	distribution	distribution	NOUN
admet-373	258	31	in	in	ADP
admet-373	258	32	octanol	octanol	NOUN
admet-373	258	33	and	and	CCONJ
admet-373	258	34	water	water	NOUN
admet-373	258	35	.	.	PUNCT
admet-373	259	1	the	the	DET
admet-373	259	2	technology	technology	NOUN
admet-373	259	3	is	be	AUX
admet-373	259	4	suitable	suitable	ADJ
admet-373	259	5	for	for	ADP
admet-373	259	6	estimating	estimate	VERB
admet-373	259	7	the	the	DET
admet-373	259	8	tissue	tissue	NOUN
admet-373	259	9	binding	bind	VERB
admet-373	259	10	,	,	PUNCT
admet-373	259	11	plasma	plasma	NOUN
admet-373	259	12	protein	protein	NOUN
admet-373	259	13	binding	bind	VERB
admet-373	259	14	,	,	PUNCT
admet-373	259	15	volume	volume	NOUN
admet-373	259	16	of	of	ADP
admet-373	259	17	distribution	distribution	NOUN
admet-373	259	18	,	,	PUNCT
admet-373	259	19	unbound	unbound	NOUN
admet-373	259	20	volume	volume	NOUN
admet-373	259	21	of	of	ADP
admet-373	259	22	distribution	distribution	NOUN
admet-373	259	23	,	,	PUNCT
admet-373	259	24	drug	drug	NOUN
admet-373	259	25	efficiency	efficiency	NOUN
admet-373	259	26	,	,	PUNCT
admet-373	259	27	promiscuity	promiscuity	NOUN
admet-373	259	28	,	,	PUNCT
admet-373	259	29	phospholipidotic	phospholipidotic	ADJ
admet-373	259	30	potential	potential	NOUN
admet-373	259	31	,	,	PUNCT
admet-373	259	32	etc	etc	X
admet-373	259	33	.	.	X
admet-373	259	34	therefore	therefore	ADV
admet-373	259	35	,	,	PUNCT
admet-373	259	36	this	this	DET
admet-373	259	37	technology	technology	NOUN
admet-373	259	38	is	be	AUX
admet-373	259	39	recommended	recommend	VERB
admet-373	259	40	for	for	ADP
admet-373	259	41	use	use	NOUN
admet-373	259	42	in	in	ADP
admet-373	259	43	early	early	ADJ
admet-373	259	44	drug	drug	NOUN
admet-373	259	45	discovery	discovery	NOUN
admet-373	259	46	programmes	programme	NOUN
admet-373	259	47	to	to	PART
admet-373	259	48	aid	aid	VERB
admet-373	259	49	the	the	DET
admet-373	259	50	compound	compound	NOUN
admet-373	259	51	triage	triage	NOUN
admet-373	259	52	process	process	NOUN
admet-373	259	53	so	so	SCONJ
admet-373	259	54	that	that	SCONJ
admet-373	259	55	only	only	ADV
admet-373	259	56	compounds	compound	VERB
admet-373	259	57	with	with	ADP
admet-373	259	58	a	a	DET
admet-373	259	59	higher	high	ADJ
admet-373	259	60	probability	probability	NOUN
admet-373	259	61	of	of	ADP
admet-373	259	62	having	have	VERB
admet-373	259	63	good	good	ADJ
admet-373	259	64	affinity	affinity	NOUN
admet-373	259	65	along	along	ADP
admet-373	259	66	with	with	ADP
admet-373	259	67	good	good	ADJ
admet-373	259	68	adme	adme	NOUN
admet-373	259	69	properties	property	NOUN
admet-373	259	70	are	be	AUX
admet-373	259	71	selected	select	VERB
admet-373	259	72	for	for	ADP
admet-373	259	73	progression	progression	NOUN
admet-373	259	74	to	to	ADP
admet-373	259	75	expensive	expensive	ADJ
admet-373	259	76	animal	animal	NOUN
admet-373	259	77	studies	study	NOUN
admet-373	259	78	.	.	PUNCT
admet-373	260	1	the	the	DET
admet-373	260	2	technology	technology	NOUN
admet-373	260	3	is	be	AUX
admet-373	260	4	commercially	commercially	ADV
admet-373	260	5	available	available	ADJ
admet-373	260	6	;	;	PUNCT
admet-373	260	7	the	the	DET
admet-373	260	8	models	model	NOUN
admet-373	260	9	have	have	AUX
admet-373	260	10	been	be	AUX
admet-373	260	11	published	publish	VERB
admet-373	260	12	in	in	ADP
admet-373	260	13	a	a	DET
admet-373	260	14	book	book	NOUN
admet-373	260	15	titled	title	VERB
admet-373	260	16	“	"	PUNCT
admet-373	260	17	physicochemical	physicochemical	ADJ
admet-373	260	18	and	and	CCONJ
admet-373	260	19	biomimetic	biomimetic	ADJ
admet-373	260	20	properties	property	NOUN
admet-373	260	21	in	in	ADP
admet-373	260	22	drug	drug	NOUN
admet-373	260	23	discovery	discovery	NOUN
admet-373	260	24	:	:	PUNCT
admet-373	260	25	chromatographic	chromatographic	ADJ
admet-373	260	26	techniques	technique	NOUN
admet-373	260	27	for	for	ADP
admet-373	260	28	lead	lead	ADJ
admet-373	260	29	optimisation	optimisation	NOUN
admet-373	260	30	”	"	PUNCT
admet-373	261	1	[	[	X
admet-373	261	2	45	45	NUM
admet-373	261	3	]	]	PUNCT
admet-373	261	4	and	and	CCONJ
admet-373	261	5	are	be	AUX
admet-373	261	6	encouraged	encourage	VERB
admet-373	261	7	to	to	PART
admet-373	261	8	be	be	AUX
admet-373	261	9	routinely	routinely	ADV
admet-373	261	10	used	use	VERB
admet-373	261	11	in	in	ADP
admet-373	261	12	the	the	DET
admet-373	261	13	early	early	ADJ
admet-373	261	14	drug	drug	NOUN
admet-373	261	15	discovery	discovery	NOUN
admet-373	261	16	process	process	NOUN
admet-373	261	17	.	.	PUNCT
admet-373	262	1	the	the	DET
admet-373	262	2	conclusion	conclusion	NOUN
admet-373	262	3	is	be	AUX
admet-373	262	4	that	that	SCONJ
admet-373	262	5	in	in	ADP
admet-373	262	6	vivo	vivo	ADJ
admet-373	262	7	data	datum	NOUN
admet-373	262	8	should	should	AUX
admet-373	262	9	not	not	PART
admet-373	262	10	be	be	AUX
admet-373	262	11	generated	generate	VERB
admet-373	262	12	until	until	SCONJ
admet-373	262	13	the	the	DET
admet-373	262	14	compounds	compound	NOUN
admet-373	262	15	have	have	AUX
admet-373	262	16	been	be	AUX
admet-373	262	17	analysed	analyse	VERB
admet-373	262	18	by	by	ADP
admet-373	262	19	chromatographic	chromatographic	ADJ
admet-373	262	20	techniques	technique	NOUN
admet-373	262	21	,	,	PUNCT
admet-373	262	22	and	and	CCONJ
admet-373	262	23	only	only	ADV
admet-373	262	24	compounds	compound	NOUN
admet-373	262	25	that	that	PRON
admet-373	262	26	are	be	AUX
admet-373	262	27	predicted	predict	VERB
admet-373	262	28	to	to	PART
admet-373	262	29	have	have	VERB
admet-373	262	30	optimal	optimal	ADJ
admet-373	262	31	in	in	ADP
admet-373	262	32	vivo	vivo	ADJ
admet-373	262	33	properties	property	NOUN
admet-373	262	34	should	should	AUX
admet-373	262	35	be	be	AUX
admet-373	262	36	progressed	progress	VERB
admet-373	262	37	for	for	ADP
admet-373	262	38	further	further	ADJ
admet-373	262	39	analysis	analysis	NOUN
admet-373	262	40	.	.	PUNCT
admet-373	263	1	the	the	DET
admet-373	263	2	proposed	propose	VERB
admet-373	263	3	alternate	alternate	ADJ
admet-373	263	4	drug	drug	NOUN
admet-373	263	5	discovery	discovery	NOUN
admet-373	263	6	process	process	NOUN
admet-373	263	7	should	should	AUX
admet-373	263	8	include	include	VERB
admet-373	263	9	(	(	PUNCT
admet-373	263	10	i	i	NOUN
admet-373	263	11	)	)	PUNCT
admet-373	263	12	potency	potency	NOUN
admet-373	263	13	evaluation	evaluation	NOUN
admet-373	263	14	or	or	CCONJ
admet-373	263	15	receptor	receptor	NOUN
admet-373	263	16	binding	bind	VERB
admet-373	263	17	and	and	CCONJ
admet-373	263	18	(	(	PUNCT
admet-373	263	19	ii	ii	NOUN
admet-373	263	20	)	)	PUNCT
admet-373	263	21	predictive	predictive	NOUN
admet-373	263	22	in	in	ADP
admet-373	263	23	vivo	vivo	ADJ
admet-373	263	24	properties	property	NOUN
admet-373	263	25	of	of	ADP
admet-373	263	26	each	each	DET
admet-373	263	27	analogues	analogue	NOUN
admet-373	263	28	.	.	PUNCT
admet-373	264	1	only	only	ADV
admet-373	264	2	after	after	SCONJ
admet-373	264	3	both	both	PRON
admet-373	264	4	of	of	ADP
admet-373	264	5	these	these	DET
admet-373	264	6	steps	step	NOUN
admet-373	264	7	are	be	AUX
admet-373	264	8	completed	complete	VERB
admet-373	264	9	should	should	AUX
admet-373	264	10	compounds	compound	NOUN
admet-373	264	11	be	be	AUX
admet-373	264	12	chosen	choose	VERB
admet-373	264	13	for	for	ADP
admet-373	264	14	further	further	ADJ
admet-373	264	15	development	development	NOUN
admet-373	264	16	by	by	ADP
admet-373	264	17	extensive	extensive	ADJ
admet-373	264	18	testing	testing	NOUN
admet-373	264	19	both	both	CCONJ
admet-373	264	20	in	in	ADP
admet-373	264	21	vitro	vitro	X
admet-373	264	22	and	and	CCONJ
admet-373	264	23	in	in	ADP
admet-373	264	24	vivo	vivo	NOUN
admet-373	264	25	.	.	PUNCT
admet-373	265	1	using	use	VERB
admet-373	265	2	this	this	DET
admet-373	265	3	approach	approach	NOUN
admet-373	265	4	will	will	AUX
admet-373	265	5	eliminate	eliminate	VERB
admet-373	265	6	numerous	numerous	ADJ
admet-373	265	7	candidates	candidate	NOUN
admet-373	265	8	from	from	ADP
admet-373	265	9	the	the	DET
admet-373	265	10	pool	pool	NOUN
admet-373	265	11	of	of	ADP
admet-373	265	12	active	active	ADJ
admet-373	265	13	analogues	analogue	NOUN
admet-373	265	14	and	and	CCONJ
admet-373	265	15	has	have	VERB
admet-373	265	16	the	the	DET
admet-373	265	17	potential	potential	NOUN
admet-373	265	18	to	to	PART
admet-373	265	19	help	help	VERB
admet-373	265	20	save	save	VERB
admet-373	265	21	considerable	considerable	ADJ
admet-373	265	22	amounts	amount	NOUN
admet-373	265	23	of	of	ADP
admet-373	265	24	time	time	NOUN
admet-373	265	25	and	and	CCONJ
admet-373	265	26	money	money	NOUN
admet-373	265	27	during	during	ADP
admet-373	265	28	the	the	DET
admet-373	265	29	process	process	NOUN
admet-373	265	30	of	of	ADP
admet-373	265	31	getting	get	VERB
admet-373	265	32	nce	nce	NOUN
admet-373	265	33	’s	’s	X
admet-373	265	34	to	to	ADP
admet-373	265	35	market	market	NOUN
admet-373	265	36	.	.	PUNCT
admet-373	266	1	even	even	ADV
admet-373	266	2	if	if	SCONJ
admet-373	266	3	only	only	ADV
admet-373	266	4	5	5	NUM
admet-373	266	5	-	-	SYM
admet-373	266	6	10	10	NUM
admet-373	266	7	compounds	compound	NOUN
admet-373	266	8	are	be	AUX
admet-373	266	9	immediately	immediately	ADV
admet-373	266	10	eliminated	eliminate	VERB
admet-373	266	11	as	as	ADP
admet-373	266	12	drug	drug	NOUN
admet-373	266	13	candidates	candidate	NOUN
admet-373	266	14	,	,	PUNCT
admet-373	266	15	this	this	PRON
admet-373	266	16	potentially	potentially	ADV
admet-373	266	17	saves	save	VERB
admet-373	266	18	millions	million	NOUN
admet-373	266	19	of	of	ADP
admet-373	266	20	dollars	dollar	NOUN
admet-373	266	21	in	in	ADP
admet-373	266	22	the	the	DET
admet-373	266	23	cost	cost	NOUN
admet-373	266	24	to	to	PART
admet-373	266	25	get	get	VERB
admet-373	266	26	a	a	DET
admet-373	266	27	drug	drug	NOUN
admet-373	266	28	to	to	ADP
admet-373	266	29	market	market	NOUN
admet-373	266	30	.	.	PUNCT
admet-373	267	1	references	reference	NOUN
admet-373	267	2	[	[	X
admet-373	267	3	1	1	X
admet-373	267	4	]	]	PUNCT
admet-373	267	5	e.	e.	PROPN
admet-373	267	6	perola	perola	PROPN
admet-373	267	7	.	.	PUNCT
admet-373	268	1	j.	j.	PROPN
admet-373	268	2	med	med	PROPN
admet-373	268	3	.	.	PROPN
admet-373	268	4	chem	chem	PROPN
admet-373	268	5	.	.	PUNCT
admet-373	269	1	53(7	53(7	NUM
admet-373	269	2	)	)	PUNCT
admet-373	269	3	(	(	PUNCT
admet-373	269	4	2010	2010	NUM
admet-373	269	5	)	)	PUNCT
admet-373	269	6	2986–2997	2986–2997	NUM
admet-373	269	7	.	.	PUNCT
admet-373	270	1	[	[	X
admet-373	270	2	2	2	NUM
admet-373	270	3	]	]	PUNCT
admet-373	270	4	a.	a.	NOUN
admet-373	270	5	cheng	cheng	PROPN
admet-373	270	6	,	,	PUNCT
admet-373	270	7	d.j	d.j	PROPN
admet-373	270	8	.	.	PROPN
admet-373	270	9	diller	diller	PROPN
admet-373	270	10	,	,	PUNCT
admet-373	270	11	s.l	s.l	PROPN
admet-373	270	12	.	.	PROPN
admet-373	270	13	dixon	dixon	PROPN
admet-373	270	14	,	,	PUNCT
admet-373	270	15	w.j	w.j	PROPN
admet-373	270	16	.	.	PROPN
admet-373	270	17	egan	egan	PROPN
admet-373	270	18	,	,	PUNCT
admet-373	270	19	g.	g.	PROPN
admet-373	270	20	lauri	lauri	PROPN
admet-373	270	21	,	,	PUNCT
admet-373	270	22	k.m	k.m	PROPN
admet-373	270	23	.	.	PROPN
admet-373	270	24	merz	merz	PROPN
admet-373	270	25	.	.	PUNCT
admet-373	271	1	j.	j.	PROPN
admet-373	271	2	comput	comput	PROPN
admet-373	271	3	.	.	PUNCT
admet-373	272	1	chem	chem	NOUN
admet-373	272	2	.	.	PUNCT
admet-373	273	1	23(1	23(1	X
admet-373	273	2	)	)	PUNCT
admet-373	273	3	(	(	PUNCT
admet-373	273	4	2002	2002	NUM
admet-373	273	5	)	)	PUNCT
admet-373	273	6	172	172	NUM
admet-373	273	7	–	–	PUNCT
admet-373	273	8	183	183	NUM
admet-373	273	9	.	.	PUNCT
admet-373	274	1	[	[	X
admet-373	274	2	3	3	X
admet-373	274	3	]	]	X
admet-373	274	4	h.	h.	PROPN
admet-373	274	5	van	van	PROPN
admet-373	274	6	de	de	PROPN
admet-373	274	7	waterbeemd	waterbeemd	PROPN
admet-373	274	8	,	,	PUNCT
admet-373	274	9	d.a	d.a	PROPN
admet-373	274	10	.	.	PROPN
admet-373	274	11	smith	smith	PROPN
admet-373	274	12	,	,	PUNCT
admet-373	274	13	k.	k.	PROPN
admet-373	274	14	beaumont	beaumont	PROPN
admet-373	274	15	,	,	PUNCT
admet-373	274	16	d.k	d.k	PROPN
admet-373	274	17	.	.	PROPN
admet-373	274	18	walker	walker	PROPN
admet-373	274	19	.	.	PUNCT
admet-373	275	1	j.	j.	PROPN
admet-373	275	2	med	med	PROPN
admet-373	275	3	.	.	PROPN
admet-373	275	4	chem	chem	PROPN
admet-373	275	5	.	.	PUNCT
admet-373	276	1	44(9	44(9	NUM
admet-373	276	2	)	)	PUNCT
admet-373	276	3	(	(	PUNCT
admet-373	276	4	2001	2001	NUM
admet-373	276	5	)	)	PUNCT
admet-373	276	6	1313	1313	NUM
admet-373	276	7	–	–	PUNCT
admet-373	276	8	1333	1333	NUM
admet-373	276	9	.	.	PUNCT
admet-373	277	1	[	[	X
admet-373	277	2	4	4	NUM
admet-373	277	3	]	]	X
admet-373	277	4	i.	i.	PROPN
admet-373	277	5	collins	collins	PROPN
admet-373	277	6	,	,	PUNCT
admet-373	277	7	p.	p.	NOUN
admet-373	277	8	workman	workman	NOUN
admet-373	277	9	.	.	PUNCT
admet-373	278	1	nat	nat	PROPN
admet-373	278	2	.	.	PUNCT
admet-373	279	1	chem	chem	PROPN
admet-373	279	2	.	.	PUNCT
admet-373	280	1	biol	biol	PROPN
admet-373	280	2	.	.	PUNCT
admet-373	281	1	2(12	2(12	NUM
admet-373	281	2	)	)	PUNCT
admet-373	281	3	(	(	PUNCT
admet-373	281	4	2006	2006	NUM
admet-373	281	5	)	)	PUNCT
admet-373	282	1	689–700	689–700	NUM
admet-373	282	2	.	.	PUNCT
admet-373	283	1	admet	admet	PROPN
admet-373	283	2	&	&	CCONJ
admet-373	283	3	dmpk	dmpk	PROPN
admet-373	283	4	5(1	5(1	NUM
admet-373	283	5	)	)	PUNCT
admet-373	283	6	(	(	PUNCT
admet-373	283	7	2017	2017	NUM
admet-373	283	8	)	)	PUNCT
admet-373	283	9	14	14	NUM
admet-373	283	10	-	-	SYM
admet-373	283	11	38	38	NUM
admet-373	283	12	in	in	ADP
admet-373	283	13	vitro	vitro	X
admet-373	283	14	membrane	membrane	NOUN
admet-373	283	15	and	and	CCONJ
admet-373	283	16	protein	protein	NOUN
admet-373	283	17	binding	bind	VERB
admet-373	283	18	doi	doi	NOUN
admet-373	283	19	:	:	PUNCT
admet-373	283	20	10.5599	10.5599	NUM
admet-373	283	21	/	/	SYM
admet-373	283	22	admet.5.1.373	admet.5.1.373	NUM
admet-373	283	23	29	29	NUM
admet-373	283	24	[	[	SYM
admet-373	283	25	5	5	NUM
admet-373	283	26	]	]	PUNCT
admet-373	283	27	a.	a.	NOUN
admet-373	283	28	avdeef	avdeef	PROPN
admet-373	283	29	.	.	PUNCT
admet-373	284	1	admet	admet	PROPN
admet-373	284	2	dmpk	dmpk	PROPN
admet-373	284	3	3(2	3(2	NUM
admet-373	284	4	)	)	PUNCT
admet-373	284	5	(	(	PUNCT
admet-373	284	6	2015	2015	NUM
admet-373	284	7	)	)	PUNCT
admet-373	284	8	84–109	84–109	NUM
admet-373	284	9	.	.	PUNCT
admet-373	285	1	[	[	X
admet-373	285	2	6	6	NUM
admet-373	285	3	]	]	PUNCT
admet-373	285	4	j.	j.	PROPN
admet-373	285	5	hughes	hughes	PROPN
admet-373	285	6	,	,	PUNCT
admet-373	285	7	s.	s.	PROPN
admet-373	285	8	rees	rees	PROPN
admet-373	285	9	,	,	PUNCT
admet-373	285	10	s.	s.	PROPN
admet-373	285	11	kalindjian	kalindjian	PROPN
admet-373	285	12	,	,	PUNCT
admet-373	285	13	k.	k.	PROPN
admet-373	285	14	philpott	philpott	PROPN
admet-373	285	15	.	.	PUNCT
admet-373	286	1	br	br	PROPN
admet-373	286	2	.	.	PUNCT
admet-373	287	1	j.	j.	PROPN
admet-373	287	2	pharmacol	pharmacol	PROPN
admet-373	287	3	.	.	PUNCT
admet-373	288	1	162(6	162(6	NUM
admet-373	288	2	)	)	PUNCT
admet-373	288	3	(	(	PUNCT
admet-373	288	4	2011	2011	NUM
admet-373	288	5	)	)	PUNCT
admet-373	288	6	1239–1249	1239–1249	NUM
admet-373	288	7	.	.	PUNCT
admet-373	289	1	[	[	X
admet-373	289	2	7	7	X
admet-373	289	3	]	]	X
admet-373	289	4	c.w	c.w	PROPN
admet-373	289	5	.	.	PROPN
admet-373	289	6	murray	murray	PROPN
admet-373	289	7	,	,	PUNCT
admet-373	289	8	d.a	d.a	PROPN
admet-373	289	9	.	.	PROPN
admet-373	289	10	erlanson	erlanson	PROPN
admet-373	289	11	,	,	PUNCT
admet-373	289	12	a.l	a.l	PROPN
admet-373	289	13	.	.	PROPN
admet-373	289	14	hopkins	hopkins	PROPN
admet-373	289	15	,	,	PUNCT
admet-373	289	16	g.m	g.m	PROPN
admet-373	289	17	.	.	PROPN
admet-373	289	18	keserü	keserü	PROPN
admet-373	289	19	,	,	PUNCT
admet-373	289	20	p.d	p.d	PROPN
admet-373	289	21	.	.	PROPN
admet-373	289	22	leeson	leeson	PROPN
admet-373	289	23	,	,	PUNCT
admet-373	289	24	d.c	d.c	PROPN
admet-373	289	25	.	.	PROPN
admet-373	289	26	rees	rees	PROPN
admet-373	289	27	,	,	PUNCT
admet-373	289	28	c.h	c.h	PROPN
admet-373	289	29	.	.	PROPN
admet-373	289	30	reynolds	reynolds	PROPN
admet-373	289	31	,	,	PUNCT
admet-373	289	32	n.j	n.j	PROPN
admet-373	289	33	.	.	PROPN
admet-373	289	34	richmond	richmond	PROPN
admet-373	289	35	.	.	PUNCT
admet-373	290	1	acs	acs	PROPN
admet-373	290	2	med	med	PROPN
admet-373	290	3	.	.	PUNCT
admet-373	291	1	chem	chem	PROPN
admet-373	291	2	.	.	PUNCT
admet-373	292	1	lett	lett	PROPN
admet-373	292	2	.	.	PUNCT
admet-373	293	1	5(6	5(6	NUM
admet-373	293	2	)	)	PUNCT
admet-373	293	3	(	(	PUNCT
admet-373	293	4	2014	2014	NUM
admet-373	293	5	)	)	PUNCT
admet-373	293	6	616	616	NUM
admet-373	293	7	-	-	SYM
admet-373	293	8	618	618	NUM
admet-373	293	9	.	.	PUNCT
admet-373	294	1	[	[	X
admet-373	294	2	8	8	NUM
admet-373	294	3	]	]	X
admet-373	294	4	a.l	a.l	PROPN
admet-373	294	5	.	.	PROPN
admet-373	294	6	hopkins	hopkins	PROPN
admet-373	294	7	,	,	PUNCT
admet-373	294	8	g.m	g.m	PROPN
admet-373	294	9	.	.	PROPN
admet-373	294	10	keserü	keserü	PROPN
admet-373	294	11	,	,	PUNCT
admet-373	294	12	p.d	p.d	PROPN
admet-373	294	13	.	.	PROPN
admet-373	294	14	leeson	leeson	PROPN
admet-373	294	15	,	,	PUNCT
admet-373	294	16	d.c	d.c	PROPN
admet-373	294	17	.	.	PROPN
admet-373	294	18	rees	rees	PROPN
admet-373	294	19	,	,	PUNCT
admet-373	294	20	c.h	c.h	PROPN
admet-373	294	21	.	.	PROPN
admet-373	294	22	reynolds	reynolds	PROPN
admet-373	294	23	.	.	PUNCT
admet-373	295	1	nature	nature	PROPN
admet-373	295	2	rev	rev	VERB
admet-373	295	3	.	.	PROPN
admet-373	295	4	drug	drug	NOUN
admet-373	295	5	discov	discov	NOUN
admet-373	295	6	.	.	PUNCT
admet-373	296	1	13(2	13(2	NOUN
admet-373	296	2	)	)	PUNCT
admet-373	296	3	(	(	PUNCT
admet-373	296	4	2014	2014	NUM
admet-373	296	5	)	)	PUNCT
admet-373	296	6	105	105	NUM
admet-373	296	7	-	-	SYM
admet-373	296	8	121	121	NUM
admet-373	296	9	.	.	PUNCT
admet-373	297	1	[	[	X
admet-373	297	2	9	9	NUM
admet-373	297	3	]	]	SYM
admet-373	297	4	j.d	j.d	PROPN
admet-373	297	5	.	.	PROPN
admet-373	297	6	hughes	hughes	PROPN
admet-373	297	7	,	,	PUNCT
admet-373	297	8	j.	j.	PROPN
admet-373	297	9	blagg	blagg	PROPN
admet-373	297	10	,	,	PUNCT
admet-373	297	11	d.a	d.a	PROPN
admet-373	297	12	.	.	PROPN
admet-373	297	13	price	price	NOUN
admet-373	297	14	,	,	PUNCT
admet-373	297	15	s.	s.	PROPN
admet-373	297	16	bailey	bailey	PROPN
admet-373	297	17	,	,	PUNCT
admet-373	297	18	g.a	g.a	PROPN
admet-373	297	19	.	.	PROPN
admet-373	297	20	decrescenzo	decrescenzo	PROPN
admet-373	297	21	,	,	PUNCT
admet-373	297	22	r.v	r.v	PROPN
admet-373	297	23	.	.	PROPN
admet-373	297	24	devraj	devraj	PROPN
admet-373	297	25	,	,	PUNCT
admet-373	298	1	et	et	PROPN
admet-373	298	2	al	al	PROPN
admet-373	298	3	.	.	PROPN
admet-373	298	4	bioorg	bioorg	PROPN
admet-373	298	5	.	.	PUNCT
admet-373	299	1	med	med	PROPN
admet-373	299	2	.	.	PROPN
admet-373	299	3	chem	chem	PROPN
admet-373	299	4	.	.	PUNCT
admet-373	300	1	lett	lett	PROPN
admet-373	300	2	.	.	PUNCT
admet-373	301	1	18(17	18(17	PROPN
admet-373	301	2	)	)	PUNCT
admet-373	301	3	(	(	PUNCT
admet-373	301	4	2008	2008	NUM
admet-373	301	5	)	)	PUNCT
admet-373	301	6	4872–4875	4872–4875	NUM
admet-373	301	7	.	.	PUNCT
admet-373	302	1	[	[	X
admet-373	302	2	10	10	NUM
admet-373	302	3	]	]	X
admet-373	302	4	a.a	a.a	PROPN
admet-373	302	5	.	.	PROPN
admet-373	302	6	nava	nava	PROPN
admet-373	302	7	-	-	PUNCT
admet-373	302	8	ocampo	ocampo	PROPN
admet-373	302	9	,	,	PUNCT
admet-373	302	10	a.m.	a.m.	PROPN
admet-373	302	11	bello	bello	PROPN
admet-373	302	12	-	-	PUNCT
admet-373	302	13	ramírez	ramírez	NOUN
admet-373	302	14	.	.	PUNCT
admet-373	303	1	clin	clin	PROPN
admet-373	303	2	.	.	PUNCT
admet-373	304	1	exp	exp	PROPN
admet-373	304	2	.	.	PUNCT
admet-373	304	3	pharmacol	pharmacol	PROPN
admet-373	304	4	.	.	PUNCT
admet-373	304	5	physiol	physiol	PROPN
admet-373	304	6	.	.	PUNCT
admet-373	305	1	31	31	NUM
admet-373	305	2	(	(	PUNCT
admet-373	305	3	2004	2004	NUM
admet-373	305	4	)	)	PUNCT
admet-373	306	1	116–118	116–118	NUM
admet-373	306	2	.	.	PUNCT
admet-373	307	1	[	[	X
admet-373	307	2	11	11	NUM
admet-373	307	3	]	]	X
admet-373	307	4	n.a	n.a	PROPN
admet-373	307	5	.	.	PROPN
admet-373	307	6	meanwell	meanwell	PROPN
admet-373	307	7	.	.	PUNCT
admet-373	308	1	chem	chem	NOUN
admet-373	308	2	.	.	PUNCT
admet-373	309	1	res	re	NOUN
admet-373	309	2	.	.	PUNCT
admet-373	310	1	toxicol	toxicol	PROPN
admet-373	310	2	.	.	PUNCT
admet-373	311	1	24(9	24(9	NUM
admet-373	311	2	)	)	PUNCT
admet-373	312	1	(	(	PUNCT
admet-373	312	2	2011	2011	NUM
admet-373	312	3	)	)	PUNCT
admet-373	312	4	1420–1456	1420–1456	NUM
admet-373	312	5	.	.	PUNCT
admet-373	313	1	[	[	X
admet-373	313	2	12	12	NUM
admet-373	313	3	]	]	X
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admet-373	315	8	)	)	PUNCT
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admet-373	315	10	.	.	PUNCT
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admet-373	316	3	]	]	X
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admet-373	317	2	.	.	PUNCT
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admet-373	318	2	.	.	PUNCT
admet-373	319	1	drug	drug	NOUN
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admet-373	319	3	.	.	PUNCT
admet-373	320	1	devel	devel	NOUN
admet-373	320	2	.	.	PUNCT
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admet-373	321	5	)	)	PUNCT
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admet-373	322	2	.	.	PUNCT
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admet-373	326	2	(	(	PUNCT
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admet-373	326	4	)	)	PUNCT
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admet-373	327	3	]	]	X
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admet-373	329	1	j.	j.	PROPN
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admet-373	330	1	sci	sci	PROPN
admet-373	330	2	.	.	PUNCT
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admet-373	331	2	-	-	PUNCT
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admet-373	331	4	)	)	PUNCT
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admet-373	331	7	)	)	PUNCT
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admet-373	331	9	.	.	PUNCT
admet-373	332	1	[	[	X
admet-373	332	2	16	16	NUM
admet-373	332	3	]	]	X
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admet-373	333	2	.	.	PUNCT
admet-373	334	1	rev	rev	PROPN
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admet-373	334	4	discov	discov	NOUN
admet-373	334	5	.	.	PUNCT
admet-373	335	1	9(12	9(12	NUM
admet-373	335	2	)	)	PUNCT
admet-373	335	3	(	(	PUNCT
admet-373	335	4	2010	2010	NUM
admet-373	335	5	)	)	PUNCT
admet-373	336	1	929–939	929–939	NUM
admet-373	336	2	.	.	PUNCT
admet-373	337	1	[	[	X
admet-373	337	2	17	17	NUM
admet-373	337	3	]	]	X
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admet-373	337	9	.	.	PROPN
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admet-373	337	11	.	.	PUNCT
admet-373	338	1	nat	nat	PROPN
admet-373	338	2	.	.	PUNCT
admet-373	339	1	rev	rev	PROPN
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admet-373	339	3	.	.	PUNCT
admet-373	340	1	7(3	7(3	NUM
admet-373	340	2	)	)	PUNCT
admet-373	340	3	(	(	PUNCT
admet-373	340	4	2008	2008	NUM
admet-373	340	5	)	)	PUNCT
admet-373	341	1	205–20	205–20	NUM
admet-373	341	2	.	.	PUNCT
admet-373	342	1	[	[	X
admet-373	342	2	18	18	NUM
admet-373	342	3	]	]	X
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admet-373	342	9	,	,	PUNCT
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admet-373	342	13	e.	e.	PROPN
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admet-373	342	15	.	.	PUNCT
admet-373	343	1	expert	expert	NOUN
admet-373	343	2	opin	opin	NOUN
admet-373	343	3	.	.	PUNCT
admet-373	344	1	drug	drug	NOUN
admet-373	344	2	discov	discov	NOUN
admet-373	344	3	.	.	PUNCT
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admet-373	345	2	(	(	PUNCT
admet-373	345	3	2010	2010	NUM
admet-373	345	4	)	)	PUNCT
admet-373	346	1	609–618	609–618	NUM
admet-373	346	2	.	.	PUNCT
admet-373	347	1	[	[	X
admet-373	347	2	19	19	NUM
admet-373	347	3	]	]	X
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admet-373	347	7	e.	e.	PROPN
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admet-373	347	9	,	,	PUNCT
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admet-373	347	11	.	.	PROPN
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admet-373	347	13	,	,	PUNCT
admet-373	347	14	s.	s.	PROPN
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admet-373	347	16	,	,	PUNCT
admet-373	347	17	r.	r.	PROPN
admet-373	347	18	longhi	longhi	PROPN
admet-373	347	19	,	,	PUNCT
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admet-373	348	1	k	k	PROPN
admet-373	348	2	,	,	PUNCT
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admet-373	348	8	.	.	PUNCT
admet-373	349	1	drug	drug	NOUN
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admet-373	350	3	(	(	PUNCT
admet-373	350	4	2011	2011	NUM
admet-373	350	5	)	)	PUNCT
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admet-373	351	2	.	.	PUNCT
admet-373	352	1	[	[	X
admet-373	352	2	20	20	NUM
admet-373	352	3	]	]	SYM
admet-373	352	4	k.a	k.a	PROPN
admet-373	352	5	.	.	PROPN
admet-373	352	6	youdim	youdim	PROPN
admet-373	352	7	,	,	PUNCT
admet-373	352	8	a.	a.	PROPN
admet-373	352	9	avdeef	avdeef	PROPN
admet-373	352	10	,	,	PUNCT
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admet-373	352	12	.	.	PROPN
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admet-373	353	1	drug	drug	PROPN
admet-373	353	2	discov	discov	PROPN
admet-373	353	3	.	.	PUNCT
admet-373	354	1	today	today	NOUN
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admet-373	354	3	)	)	PUNCT
admet-373	354	4	(	(	PUNCT
admet-373	354	5	2003	2003	NUM
admet-373	354	6	)	)	PUNCT
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admet-373	354	8	.	.	PUNCT
admet-373	355	1	[	[	X
admet-373	355	2	21	21	NUM
admet-373	355	3	]	]	X
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admet-373	355	8	,	,	PUNCT
admet-373	355	9	l.	l.	PROPN
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admet-373	355	11	,	,	PUNCT
admet-373	355	12	h.	h.	PROPN
admet-373	355	13	xhaard	xhaard	PROPN
admet-373	355	14	,	,	PUNCT
admet-373	355	15	m.	m.	NOUN
admet-373	355	16	yliperttula	yliperttula	PROPN
admet-373	355	17	,	,	PUNCT
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admet-373	355	20	,	,	PUNCT
admet-373	355	21	h.	h.	PROPN
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admet-373	355	23	.	.	PUNCT
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admet-373	356	4	)	)	PUNCT
admet-373	356	5	(	(	PUNCT
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admet-373	356	7	)	)	PUNCT
admet-373	356	8	1	1	NUM
admet-373	356	9	-	-	SYM
admet-373	356	10	12	12	NUM
admet-373	356	11	.	.	PUNCT
admet-373	357	1	[	[	X
admet-373	357	2	22	22	NUM
admet-373	357	3	]	]	PUNCT
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admet-373	357	6	,	,	PUNCT
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admet-373	357	10	,	,	PUNCT
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admet-373	357	12	.	.	PROPN
admet-373	357	13	dexter	dexter	PROPN
admet-373	357	14	,	,	PUNCT
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admet-373	357	19	s.	s.	PROPN
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admet-373	357	25	,	,	PUNCT
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admet-373	358	4	.	.	PUNCT
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admet-373	359	2	)	)	PUNCT
admet-373	359	3	(	(	PUNCT
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admet-373	359	5	)	)	PUNCT
admet-373	360	1	322–327	322–327	NUM
admet-373	360	2	.	.	PUNCT
admet-373	361	1	[	[	X
admet-373	361	2	23	23	NUM
admet-373	361	3	]	]	X
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admet-373	361	10	.	.	PUNCT
admet-373	362	1	nat	nat	PROPN
admet-373	362	2	.	.	PUNCT
admet-373	363	1	rev	rev	PROPN
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admet-373	364	2	)	)	PUNCT
admet-373	364	3	(	(	PUNCT
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admet-373	364	5	)	)	PUNCT
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admet-373	365	2	.	.	PUNCT
admet-373	366	1	[	[	X
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admet-373	366	3	]	]	PUNCT
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admet-373	366	9	,	,	PUNCT
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admet-373	366	11	reist	reist	PROPN
admet-373	366	12	,	,	PUNCT
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admet-373	366	16	perspect	perspect	VERB
admet-373	366	17	.	.	PUNCT
admet-373	367	1	drug	drug	NOUN
admet-373	367	2	discovery	discovery	PROPN
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admet-373	367	6	(	(	PUNCT
admet-373	367	7	2000	2000	NUM
admet-373	367	8	)	)	PUNCT
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admet-373	367	10	.	.	PUNCT
admet-373	368	1	[	[	X
admet-373	368	2	25	25	NUM
admet-373	368	3	]	]	PUNCT
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admet-373	368	9	,	,	PUNCT
admet-373	368	10	s.	s.	PROPN
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admet-373	368	12	,	,	PUNCT
admet-373	368	13	b.	b.	PROPN
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admet-373	368	16	a.	a.	PROPN
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admet-373	368	20	roberts	roberts	PROPN
admet-373	368	21	,	,	PUNCT
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admet-373	368	23	al	al	PROPN
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admet-373	369	2	.	.	PUNCT
admet-373	370	1	38(2	38(2	NUM
admet-373	370	2	)	)	PUNCT
admet-373	370	3	(	(	PUNCT
admet-373	370	4	2010	2010	NUM
admet-373	370	5	)	)	PUNCT
admet-373	371	1	223–331	223–331	NUM
admet-373	371	2	.	.	PUNCT
admet-373	372	1	[	[	X
admet-373	372	2	26	26	NUM
admet-373	372	3	]	]	X
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admet-373	372	5	.	.	PROPN
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admet-373	372	7	,	,	PUNCT
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admet-373	372	11	.	.	PUNCT
admet-373	373	1	nat	nat	PROPN
admet-373	373	2	.	.	PUNCT
admet-373	374	1	rev	rev	PROPN
admet-373	374	2	.	.	PROPN
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admet-373	374	5	.	.	PUNCT
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admet-373	375	2	)	)	PUNCT
admet-373	375	3	(	(	PUNCT
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admet-373	375	5	)	)	PUNCT
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admet-373	376	2	.	.	PUNCT
admet-373	377	1	[	[	X
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admet-373	377	9	.	.	PUNCT
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admet-373	377	13	.	.	PROPN
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admet-373	377	17	.	.	PROPN
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admet-373	377	19	.	.	PUNCT
admet-373	378	1	drug	drug	NOUN
admet-373	378	2	discov	discov	NOUN
admet-373	378	3	.	.	PUNCT
admet-373	379	1	today	today	NOUN
admet-373	379	2	16(17	16(17	PROPN
admet-373	379	3	-	-	SYM
admet-373	379	4	18	18	NUM
admet-373	379	5	)	)	PUNCT
admet-373	379	6	(	(	PUNCT
admet-373	379	7	2011	2011	NUM
admet-373	379	8	)	)	PUNCT
admet-373	380	1	822–830	822–830	NUM
admet-373	380	2	.	.	PUNCT
admet-373	381	1	[	[	X
admet-373	381	2	28	28	NUM
admet-373	381	3	]	]	X
admet-373	381	4	c.	c.	PROPN
admet-373	381	5	hansch	hansch	PROPN
admet-373	381	6	,	,	PUNCT
admet-373	381	7	t.	t.	PROPN
admet-373	381	8	fujita	fujita	PROPN
admet-373	381	9	.	.	PUNCT
admet-373	382	1	p	p	X
admet-373	382	2	-σ	-σ	NOUN
admet-373	382	3	-	-	PUNCT
admet-373	382	4	π	π	NOUN
admet-373	382	5	analysis	analysis	NOUN
admet-373	382	6	.	.	PUNCT
admet-373	383	1	j.	j.	PROPN
admet-373	383	2	am	am	PROPN
admet-373	383	3	.	.	PUNCT
admet-373	384	1	chem	chem	NOUN
admet-373	384	2	.	.	PUNCT
admet-373	385	1	soc	soc	PROPN
admet-373	385	2	.	.	PUNCT
admet-373	386	1	86(8	86(8	NUM
admet-373	386	2	)	)	PUNCT
admet-373	386	3	(	(	PUNCT
admet-373	386	4	1964	1964	NUM
admet-373	386	5	)	)	PUNCT
admet-373	386	6	1616–1626	1616–1626	NUM
admet-373	386	7	.	.	PUNCT
admet-373	387	1	[	[	X
admet-373	387	2	29	29	NUM
admet-373	387	3	]	]	X
admet-373	387	4	m.d	m.d	PROPN
admet-373	387	5	.	.	PROPN
admet-373	387	6	donovan	donovan	PROPN
admet-373	387	7	.	.	PUNCT
admet-373	388	1	j.	j.	PROPN
admet-373	388	2	womens	womens	PROPN
admet-373	388	3	health	health	PROPN
admet-373	388	4	14(1	14(1	NUM
admet-373	388	5	)	)	PUNCT
admet-373	388	6	(	(	PUNCT
admet-373	388	7	2005	2005	NUM
admet-373	388	8	)	)	PUNCT
admet-373	389	1	30–37	30–37	NUM
admet-373	389	2	.	.	PUNCT
admet-373	390	1	[	[	X
admet-373	390	2	30	30	NUM
admet-373	390	3	]	]	X
admet-373	390	4	j.	j.	PROPN
admet-373	390	5	faulkner	faulkner	PROPN
admet-373	390	6	,	,	PUNCT
admet-373	390	7	d.	d.	PROPN
admet-373	390	8	mcgibney	mcgibney	PROPN
admet-373	390	9	,	,	PUNCT
admet-373	390	10	l.	l.	PROPN
admet-373	390	11	chasseaud	chasseaud	PROPN
admet-373	390	12	,	,	PUNCT
admet-373	390	13	j.	j.	PROPN
admet-373	390	14	perry	perry	PROPN
admet-373	390	15	,	,	PUNCT
admet-373	390	16	i.	i.	PROPN
admet-373	390	17	taylor	taylor	PROPN
admet-373	390	18	.	.	PUNCT
admet-373	391	1	br	br	PROPN
admet-373	391	2	.	.	PUNCT
admet-373	392	1	j.	j.	PROPN
admet-373	392	2	clin	clin	PROPN
admet-373	392	3	.	.	PUNCT
admet-373	393	1	pharmacol	pharmacol	PROPN
admet-373	393	2	.	.	PUNCT
admet-373	394	1	22(1	22(1	NUM
admet-373	394	2	)	)	PUNCT
admet-373	395	1	(	(	PUNCT
admet-373	395	2	1986	1986	NUM
admet-373	395	3	)	)	PUNCT
admet-373	395	4	21–25	21–25	NUM
admet-373	395	5	.	.	PUNCT
admet-373	396	1	[	[	X
admet-373	396	2	31	31	NUM
admet-373	396	3	]	]	PUNCT
admet-373	396	4	c.	c.	NOUN
admet-373	396	5	pidgeon	pidgeon	PROPN
admet-373	396	6	,	,	PUNCT
admet-373	396	7	s.	s.	PROPN
admet-373	396	8	ong	ong	PROPN
admet-373	396	9	,	,	PUNCT
admet-373	396	10	h.	h.	PROPN
admet-373	396	11	choi	choi	PROPN
admet-373	396	12	,	,	PUNCT
admet-373	396	13	h.	h.	PROPN
admet-373	396	14	liu	liu	PROPN
admet-373	396	15	.	.	PUNCT
admet-373	397	1	anal	anal	PROPN
admet-373	397	2	.	.	PUNCT
admet-373	398	1	chem	chem	NOUN
admet-373	398	2	.	.	PUNCT
admet-373	399	1	66(17	66(17	NUM
admet-373	399	2	)	)	PUNCT
admet-373	399	3	(	(	PUNCT
admet-373	399	4	1994	1994	NUM
admet-373	399	5	)	)	PUNCT
admet-373	399	6	2701–2709	2701–2709	NOUN
admet-373	399	7	.	.	PUNCT
admet-373	400	1	[	[	X
admet-373	400	2	32	32	NUM
admet-373	400	3	]	]	X
admet-373	400	4	c.y	c.y	PROPN
admet-373	400	5	.	.	PROPN
admet-373	400	6	yang	yang	PROPN
admet-373	400	7	,	,	PUNCT
admet-373	400	8	s.j	s.j	PROPN
admet-373	400	9	.	.	PROPN
admet-373	400	10	cai	cai	PROPN
admet-373	400	11	,	,	PUNCT
admet-373	400	12	h.	h.	PROPN
admet-373	400	13	liu	liu	PROPN
admet-373	400	14	,	,	PUNCT
admet-373	400	15	c.	c.	PROPN
admet-373	400	16	pidgeon	pidgeon	PROPN
admet-373	400	17	.	.	PUNCT
admet-373	401	1	adv	adv	PROPN
admet-373	401	2	.	.	PUNCT
admet-373	401	3	drug	drug	PROPN
admet-373	401	4	deliv	deliv	PROPN
admet-373	401	5	.	.	PUNCT
admet-373	402	1	rev	rev	PROPN
admet-373	402	2	.	.	PROPN
admet-373	403	1	23(96	23(96	NUM
admet-373	403	2	)	)	PUNCT
admet-373	403	3	(	(	PUNCT
admet-373	403	4	1996	1996	NUM
admet-373	403	5	)	)	PUNCT
admet-373	404	1	229–256	229–256	NUM
admet-373	404	2	.	.	PUNCT
admet-373	405	1	[	[	X
admet-373	405	2	33	33	NUM
admet-373	405	3	]	]	PUNCT
admet-373	405	4	c.	c.	NOUN
admet-373	405	5	pidgeon	pidgeon	PROPN
admet-373	405	6	.	.	PUNCT
admet-373	406	1	ep0408585a1	ep0408585a1	PROPN
admet-373	406	2	immobilized	immobilize	VERB
admet-373	406	3	artificial	artificial	ADJ
admet-373	406	4	membranes	membrane	NOUN
admet-373	406	5	,	,	PUNCT
admet-373	406	6	int	int	NOUN
admet-373	406	7	pub	pub	NOUN
admet-373	406	8	patent	patent	NOUN
admet-373	407	1	no	no	DET
admet-373	407	2	wo	will	AUX
admet-373	407	3	89/08/30	89/08/30	NUM
admet-373	407	4	,	,	PUNCT
admet-373	407	5	filing	filing	NOUN
admet-373	407	6	:	:	PUNCT
admet-373	407	7	21	21	NUM
admet-373	407	8	february	february	NOUN
admet-373	407	9	1989	1989	NUM
admet-373	407	10	.	.	PUNCT
admet-373	408	1	[	[	X
admet-373	408	2	34	34	NUM
admet-373	408	3	]	]	X
admet-373	408	4	s.k	s.k	PROPN
admet-373	408	5	.	.	PROPN
admet-373	408	6	wiedmer	wiedmer	PROPN
admet-373	408	7	,	,	PUNCT
admet-373	408	8	m.l	m.l	PROPN
admet-373	408	9	.	.	PROPN
admet-373	408	10	riekkola	riekkola	PROPN
admet-373	408	11	,	,	PUNCT
admet-373	408	12	m.s	m.s	PROPN
admet-373	408	13	.	.	PROPN
admet-373	408	14	jussila	jussila	PROPN
admet-373	408	15	.	.	PUNCT
admet-373	409	1	trends	trend	NOUN
admet-373	409	2	anal	anal	PROPN
admet-373	409	3	.	.	PUNCT
admet-373	410	1	chem	chem	PROPN
admet-373	410	2	.	.	PUNCT
admet-373	411	1	23(8	23(8	NUM
admet-373	411	2	)	)	PUNCT
admet-373	411	3	(	(	PUNCT
admet-373	411	4	2004	2004	NUM
admet-373	411	5	)	)	PUNCT
admet-373	412	1	562–582	562–582	NUM
admet-373	412	2	.	.	PUNCT
admet-373	413	1	[	[	X
admet-373	413	2	35	35	NUM
admet-373	413	3	]	]	X
admet-373	413	4	y.	y.	PROPN
admet-373	413	5	kumada	kumada	PROPN
admet-373	413	6	,	,	PUNCT
admet-373	413	7	m.	m.	NOUN
admet-373	413	8	nogami	nogami	PROPN
admet-373	413	9	,	,	PUNCT
admet-373	413	10	n.	n.	PROPN
admet-373	413	11	minami	minami	PROPN
admet-373	413	12	,	,	PUNCT
admet-373	413	13	m.	m.	NOUN
admet-373	413	14	maehara	maehara	PROPN
admet-373	413	15	,	,	PUNCT
admet-373	413	16	s.	s.	PROPN
admet-373	413	17	katoh	katoh	PROPN
admet-373	413	18	.	.	PUNCT
admet-373	414	1	j.	j.	PROPN
admet-373	414	2	chromatogr	chromatogr	PROPN
admet-373	414	3	.	.	PUNCT
admet-373	415	1	a	a	DET
admet-373	415	2	1080(1	1080(1	NUM
admet-373	415	3	)	)	PUNCT
admet-373	415	4	(	(	PUNCT
admet-373	415	5	2005	2005	NUM
admet-373	415	6	)	)	PUNCT
admet-373	415	7	22–28	22–28	NUM
admet-373	415	8	.	.	PUNCT
admet-373	416	1	[	[	X
admet-373	416	2	36	36	NUM
admet-373	416	3	]	]	X
admet-373	416	4	x.y	x.y	PROPN
admet-373	416	5	.	.	PROPN
admet-373	416	6	liu	liu	PROPN
admet-373	416	7	,	,	PUNCT
admet-373	416	8	q.	q.	PROPN
admet-373	416	9	yang	yang	PROPN
admet-373	416	10	,	,	PUNCT
admet-373	416	11	n.	n.	PROPN
admet-373	416	12	kamo	kamo	PROPN
admet-373	416	13	,	,	PUNCT
admet-373	416	14	j.	j.	PROPN
admet-373	416	15	miyake	miyake	PROPN
admet-373	416	16	.	.	PUNCT
admet-373	417	1	j.	j.	PROPN
admet-373	417	2	chromatogr	chromatogr	PROPN
admet-373	417	3	.	.	PUNCT
admet-373	418	1	a	a	DET
admet-373	418	2	913	913	NUM
admet-373	418	3	(	(	PUNCT
admet-373	418	4	2001	2001	NUM
admet-373	418	5	)	)	PUNCT
admet-373	418	6	123–131	123–131	NUM
admet-373	418	7	.	.	PUNCT
admet-373	419	1	[	[	X
admet-373	419	2	37	37	NUM
admet-373	419	3	]	]	PUNCT
admet-373	419	4	k.	k.	PROPN
admet-373	419	5	valko	valko	PROPN
admet-373	419	6	,	,	PUNCT
admet-373	419	7	s.	s.	PROPN
admet-373	419	8	nunhuck	nunhuck	PROPN
admet-373	419	9	,	,	PUNCT
admet-373	419	10	c.	c.	PROPN
admet-373	419	11	bevan	bevan	PROPN
admet-373	419	12	,	,	PUNCT
admet-373	419	13	m.h	m.h	PROPN
admet-373	419	14	.	.	PROPN
admet-373	419	15	abraham	abraham	PROPN
admet-373	419	16	,	,	PUNCT
admet-373	419	17	d.p	d.p	PROPN
admet-373	419	18	.	.	PROPN
admet-373	419	19	reynolds	reynolds	PROPN
admet-373	419	20	.	.	PUNCT
admet-373	420	1	j.	j.	PROPN
admet-373	420	2	pharm	pharm	PROPN
admet-373	420	3	.	.	PUNCT
admet-373	421	1	sci	sci	PROPN
admet-373	421	2	.	.	PUNCT
admet-373	422	1	92(11	92(11	NUM
admet-373	422	2	)	)	PUNCT
admet-373	422	3	(	(	PUNCT
admet-373	422	4	2003	2003	NUM
admet-373	422	5	)	)	PUNCT
admet-373	422	6	2236–2248	2236–2248	NUM
admet-373	422	7	.	.	PUNCT
admet-373	423	1	[	[	X
admet-373	423	2	38	38	NUM
admet-373	423	3	]	]	PUNCT
admet-373	423	4	j.	j.	PROPN
admet-373	423	5	reilly	reilly	PROPN
admet-373	423	6	,	,	PUNCT
admet-373	423	7	d.	d.	PROPN
admet-373	423	8	etheridge	etheridge	PROPN
admet-373	423	9	,	,	PUNCT
admet-373	423	10	b.	b.	PROPN
admet-373	423	11	everatt	everatt	PROPN
admet-373	423	12	,	,	PUNCT
admet-373	423	13	z.	z.	PROPN
admet-373	423	14	jiang	jiang	PROPN
admet-373	423	15	,	,	PUNCT
admet-373	423	16	c.	c.	PROPN
admet-373	423	17	aldcroft	aldcroft	PROPN
admet-373	423	18	,	,	PUNCT
admet-373	423	19	p.	p.	PROPN
admet-373	423	20	wright	wright	PROPN
admet-373	423	21	,	,	PUNCT
admet-373	423	22	et	et	PROPN
admet-373	423	23	al	al	PROPN
admet-373	423	24	.	.	PUNCT
admet-373	424	1	j.	j.	PROPN
admet-373	424	2	liq	liq	PROPN
admet-373	424	3	.	.	PUNCT
admet-373	425	1	chromatogr	chromatogr	PROPN
admet-373	425	2	.	.	PUNCT
admet-373	426	1	relat	relat	PROPN
admet-373	426	2	.	.	PUNCT
admet-373	427	1	technol	technol	NOUN
admet-373	427	2	.	.	PUNCT
admet-373	428	1	34(4	34(4	NUM
admet-373	428	2	)	)	PUNCT
admet-373	428	3	(	(	PUNCT
admet-373	428	4	2011	2011	NUM
admet-373	428	5	)	)	PUNCT
admet-373	429	1	317–327	317–327	NUM
admet-373	429	2	.	.	PUNCT
admet-373	430	1	[	[	X
admet-373	430	2	39	39	NUM
admet-373	430	3	]	]	PUNCT
admet-373	430	4	f.	f.	PROPN
admet-373	430	5	beaudry	beaudry	PROPN
admet-373	430	6	,	,	PUNCT
admet-373	430	7	m.	m.	PROPN
admet-373	430	8	coutu	coutu	PROPN
admet-373	430	9	,	,	PUNCT
admet-373	430	10	n.k	n.k	PROPN
admet-373	430	11	.	.	PROPN
admet-373	430	12	brown	brown	PROPN
admet-373	430	13	.	.	PUNCT
admet-373	430	14	biomed	biome	VERB
admet-373	430	15	.	.	PUNCT
admet-373	431	1	chromatogr	chromatogr	PROPN
admet-373	431	2	.	.	PUNCT
admet-373	432	1	13(6	13(6	NUM
admet-373	432	2	)	)	PUNCT
admet-373	432	3	(	(	PUNCT
admet-373	432	4	1999	1999	NUM
admet-373	432	5	)	)	PUNCT
admet-373	433	1	401–406	401–406	NUM
admet-373	433	2	.	.	PUNCT
admet-373	434	1	[	[	X
admet-373	434	2	40	40	NUM
admet-373	434	3	]	]	PUNCT
admet-373	434	4	m.	m.	NOUN
admet-373	434	5	chrysanthakopoulos	chrysanthakopoulo	NOUN
admet-373	434	6	,	,	PUNCT
admet-373	434	7	t.	t.	NOUN
admet-373	434	8	vallianatou	vallianatou	NOUN
admet-373	434	9	,	,	PUNCT
admet-373	434	10	c.	c.	PROPN
admet-373	434	11	giaginis	giaginis	PROPN
admet-373	434	12	,	,	PUNCT
admet-373	434	13	a.	a.	NOUN
admet-373	434	14	tsantili	tsantili	NOUN
admet-373	434	15	-	-	PUNCT
admet-373	434	16	kakoulidou	kakoulidou	NOUN
admet-373	434	17	.	.	PUNCT
admet-373	435	1	eur	eur	PROPN
admet-373	435	2	.	.	PUNCT
admet-373	436	1	j.	j.	PROPN
admet-373	436	2	pharm	pharm	PROPN
admet-373	436	3	.	.	PUNCT
admet-373	437	1	sci	sci	PROPN
admet-373	437	2	.	.	PROPN
admet-373	438	1	60	60	NUM
admet-373	438	2	(	(	PUNCT
admet-373	438	3	2014	2014	NUM
admet-373	438	4	)	)	PUNCT
admet-373	438	5	24–31	24–31	NUM
admet-373	438	6	.	.	PUNCT
admet-373	439	1	[	[	X
admet-373	439	2	41	41	NUM
admet-373	439	3	]	]	X
admet-373	439	4	s.	s.	PROPN
admet-373	439	5	taheri	taheri	PROPN
admet-373	439	6	,	,	PUNCT
admet-373	439	7	l.p	l.p	PROPN
admet-373	439	8	.	.	PROPN
admet-373	439	9	cogswell	cogswell	PROPN
admet-373	439	10	,	,	PUNCT
admet-373	439	11	a.	a.	NOUN
admet-373	439	12	gent	gent	NOUN
admet-373	439	13	,	,	PUNCT
admet-373	439	14	g.r	g.r	PROPN
admet-373	439	15	.	.	PROPN
admet-373	439	16	strichartz	strichartz	PROPN
admet-373	439	17	.	.	PUNCT
admet-373	440	1	j.	j.	PROPN
admet-373	440	2	pharmacol	pharmacol	PROPN
admet-373	440	3	.	.	PUNCT
admet-373	441	1	exp	exp	PROPN
admet-373	441	2	.	.	PUNCT
admet-373	442	1	ther	ther	PROPN
admet-373	442	2	.	.	PUNCT
admet-373	443	1	304(1	304(1	NUM
admet-373	443	2	)	)	PUNCT
admet-373	443	3	(	(	PUNCT
admet-373	443	4	2003	2003	NUM
admet-373	443	5	)	)	PUNCT
admet-373	444	1	71–80	71–80	NUM
admet-373	444	2	.	.	PUNCT
admet-373	445	1	valko	valko	PROPN
admet-373	445	2	,	,	PUNCT
admet-373	445	3	teague	teague	NOUN
admet-373	445	4	and	and	CCONJ
admet-373	445	5	pidgeon	pidgeon	PROPN
admet-373	445	6	admet	admet	PROPN
admet-373	445	7	&	&	CCONJ
admet-373	445	8	dmpk	dmpk	PROPN
admet-373	445	9	5(1	5(1	NUM
admet-373	445	10	)	)	PUNCT
admet-373	445	11	(	(	PUNCT
admet-373	445	12	2017	2017	NUM
admet-373	445	13	)	)	PUNCT
admet-373	445	14	14	14	NUM
admet-373	445	15	-	-	SYM
admet-373	445	16	38	38	NUM
admet-373	445	17	30	30	NUM
admet-373	445	18	[	[	SYM
admet-373	445	19	42	42	NUM
admet-373	445	20	]	]	PUNCT
admet-373	445	21	f.	f.	PROPN
admet-373	445	22	hollosy	hollosy	PROPN
admet-373	445	23	,	,	PUNCT
admet-373	445	24	k.	k.	PROPN
admet-373	445	25	valko	valko	PROPN
admet-373	445	26	,	,	PUNCT
admet-373	445	27	a.	a.	PROPN
admet-373	445	28	hersey	hersey	PROPN
admet-373	445	29	,	,	PUNCT
admet-373	445	30	s.	s.	PROPN
admet-373	445	31	nunhuck	nunhuck	PROPN
admet-373	445	32	,	,	PUNCT
admet-373	445	33	g.	g.	PROPN
admet-373	445	34	keri	keri	PROPN
admet-373	445	35	,	,	PUNCT
admet-373	445	36	c.	c.	PROPN
admet-373	445	37	bevan	bevan	PROPN
admet-373	445	38	,	,	PUNCT
admet-373	445	39	et	et	PROPN
admet-373	445	40	al	al	PROPN
admet-373	445	41	.	.	PUNCT
admet-373	446	1	j.	j.	PROPN
admet-373	446	2	med	med	PROPN
admet-373	446	3	.	.	PROPN
admet-373	446	4	chem	chem	PROPN
admet-373	446	5	.	.	PUNCT
admet-373	447	1	49(24	49(24	NUM
admet-373	447	2	)	)	PUNCT
admet-373	447	3	(	(	PUNCT
admet-373	447	4	2006	2006	NUM
admet-373	447	5	)	)	PUNCT
admet-373	447	6	6958	6958	NUM
admet-373	447	7	–	–	PUNCT
admet-373	447	8	6971	6971	NUM
admet-373	447	9	.	.	PUNCT
admet-373	448	1	[	[	X
admet-373	448	2	43	43	NUM
admet-373	448	3	]	]	X
admet-373	448	4	k.l	k.l	PROPN
admet-373	448	5	.	.	PROPN
admet-373	448	6	valkó	valkó	PROPN
admet-373	448	7	,	,	PUNCT
admet-373	448	8	s.b	s.b	PROPN
admet-373	448	9	.	.	PROPN
admet-373	448	10	nunhuck	nunhuck	PROPN
admet-373	448	11	,	,	PUNCT
admet-373	448	12	a.p	a.p	PROPN
admet-373	448	13	.	.	PROPN
admet-373	448	14	hill	hill	PROPN
admet-373	448	15	.	.	PUNCT
admet-373	449	1	j.	j.	PROPN
admet-373	449	2	pharm	pharm	PROPN
admet-373	449	3	.	.	PUNCT
admet-373	450	1	sci	sci	PROPN
admet-373	450	2	.	.	PUNCT
admet-373	451	1	100(3	100(3	NUM
admet-373	451	2	)	)	PUNCT
admet-373	451	3	(	(	PUNCT
admet-373	451	4	2011	2011	NUM
admet-373	451	5	)	)	PUNCT
admet-373	452	1	849–862	849–862	NUM
admet-373	452	2	.	.	PUNCT
admet-373	453	1	[	[	X
admet-373	453	2	44	44	NUM
admet-373	453	3	]	]	PUNCT
admet-373	453	4	x.	x.	NOUN
admet-373	453	5	zhao	zhao	PROPN
admet-373	453	6	,	,	PUNCT
admet-373	453	7	w.	w.	PROPN
admet-373	453	8	chen	chen	PROPN
admet-373	453	9	,	,	PUNCT
admet-373	453	10	z.	z.	PROPN
admet-373	453	11	zhou	zhou	PROPN
admet-373	453	12	,	,	PUNCT
admet-373	453	13	q.	q.	PROPN
admet-373	453	14	wang	wang	PROPN
admet-373	453	15	,	,	PUNCT
admet-373	453	16	z.	z.	PROPN
admet-373	453	17	liu	liu	PROPN
admet-373	453	18	,	,	PUNCT
admet-373	453	19	r.	r.	PROPN
admet-373	453	20	moaddel	moaddel	PROPN
admet-373	453	21	,	,	PUNCT
admet-373	453	22	et	et	PROPN
admet-373	453	23	al	al	PROPN
admet-373	453	24	.	.	PUNCT
admet-373	454	1	j.	j.	PROPN
admet-373	454	2	chromatogr	chromatogr	PROPN
admet-373	454	3	.	.	PUNCT
admet-373	455	1	a	a	DET
admet-373	455	2	1407	1407	NUM
admet-373	455	3	(	(	PUNCT
admet-373	455	4	2015	2015	NUM
admet-373	455	5	)	)	PUNCT
admet-373	455	6	176–183	176–183	NUM
admet-373	455	7	.	.	PUNCT
admet-373	456	1	[	[	X
admet-373	456	2	45	45	NUM
admet-373	456	3	]	]	PUNCT
admet-373	456	4	k.	k.	PROPN
admet-373	456	5	valko	valko	PROPN
admet-373	456	6	.	.	PUNCT
admet-373	457	1	physicochemical	physicochemical	ADJ
admet-373	457	2	and	and	CCONJ
admet-373	457	3	biomimetic	biomimetic	ADJ
admet-373	457	4	properties	property	NOUN
admet-373	457	5	in	in	ADP
admet-373	457	6	drug	drug	NOUN
admet-373	457	7	discovery	discovery	NOUN
admet-373	457	8	:	:	PUNCT
admet-373	457	9	chromatographic	chromatographic	ADJ
admet-373	457	10	techniques	technique	NOUN
admet-373	457	11	for	for	ADP
admet-373	457	12	lead	lead	ADJ
admet-373	457	13	optimization	optimization	NOUN
admet-373	457	14	.	.	PUNCT
admet-373	458	1	wiley	wiley	PROPN
admet-373	458	2	hoboken	hoboken	PROPN
admet-373	458	3	nj	nj	PROPN
admet-373	458	4	;	;	PUNCT
admet-373	458	5	2014	2014	NUM
admet-373	458	6	.	.	PUNCT
admet-373	459	1	226	226	NUM
admet-373	459	2	p.	p.	NOUN
admet-373	460	1	[	[	X
admet-373	460	2	46	46	NUM
admet-373	460	3	]	]	X
admet-373	460	4	k.m	k.m	PROPN
admet-373	460	5	.	.	PROPN
admet-373	460	6	wasan	wasan	PROPN
admet-373	460	7	,	,	PUNCT
admet-373	460	8	d.r	d.r	PROPN
admet-373	460	9	.	.	PROPN
admet-373	460	10	brocks	brocks	PROPN
admet-373	460	11	,	,	PUNCT
admet-373	460	12	s.d	s.d	PROPN
admet-373	460	13	.	.	PROPN
admet-373	460	14	lee	lee	PROPN
admet-373	460	15	,	,	PUNCT
admet-373	460	16	k.	k.	PROPN
admet-373	460	17	sachs	sachs	PROPN
admet-373	460	18	-	-	PUNCT
admet-373	460	19	barrable	barrable	ADJ
admet-373	460	20	,	,	PUNCT
admet-373	460	21	s.j	s.j	PROPN
admet-373	460	22	.	.	PROPN
admet-373	460	23	thornton	thornton	PROPN
admet-373	460	24	.	.	PUNCT
admet-373	461	1	nat	nat	PROPN
admet-373	461	2	.	.	PUNCT
admet-373	462	1	rev	rev	PROPN
admet-373	462	2	.	.	PROPN
admet-373	462	3	drug	drug	NOUN
admet-373	462	4	discov	discov	NOUN
admet-373	462	5	.	.	PUNCT
admet-373	463	1	7(1	7(1	NUM
admet-373	463	2	)	)	PUNCT
admet-373	463	3	(	(	PUNCT
admet-373	463	4	2008	2008	NUM
admet-373	463	5	)	)	PUNCT
admet-373	463	6	84–99	84–99	NUM
admet-373	463	7	.	.	PUNCT
admet-373	464	1	[	[	X
admet-373	464	2	47	47	NUM
admet-373	464	3	]	]	PUNCT
admet-373	464	4	a.	a.	NOUN
admet-373	464	5	casartelli	casartelli	PROPN
admet-373	464	6	,	,	PUNCT
admet-373	464	7	m.	m.	NOUN
admet-373	464	8	bonato	bonato	PROPN
admet-373	464	9	,	,	PUNCT
admet-373	464	10	p.	p.	PROPN
admet-373	464	11	cristofori	cristofori	PROPN
admet-373	464	12	,	,	PUNCT
admet-373	464	13	f.	f.	PROPN
admet-373	464	14	crivellente	crivellente	PROPN
admet-373	464	15	,	,	PUNCT
admet-373	464	16	g.	g.	PROPN
admet-373	464	17	dal	dal	PROPN
admet-373	464	18	negro	negro	PROPN
admet-373	464	19	,	,	PUNCT
admet-373	464	20	i.	i.	NOUN
admet-373	464	21	masotto	masotto	PROPN
admet-373	464	22	,	,	PUNCT
admet-373	464	23	et	et	PROPN
admet-373	464	24	al	al	PROPN
admet-373	464	25	.	.	PROPN
admet-373	464	26	cell	cell	PROPN
admet-373	464	27	biol	biol	PROPN
admet-373	464	28	.	.	PUNCT
admet-373	465	1	toxicol	toxicol	PROPN
admet-373	465	2	.	.	PUNCT
admet-373	466	1	19(3	19(3	NUM
admet-373	466	2	)	)	PUNCT
admet-373	466	3	(	(	PUNCT
admet-373	466	4	2003	2003	NUM
admet-373	466	5	)	)	PUNCT
admet-373	467	1	161–176	161–176	NUM
admet-373	467	2	.	.	PUNCT
admet-373	468	1	[	[	X
admet-373	468	2	48	48	NUM
admet-373	468	3	]	]	X
admet-373	468	4	l.j	l.j	PROPN
admet-373	468	5	.	.	PROPN
admet-373	468	6	gordon	gordon	PROPN
admet-373	468	7	,	,	PUNCT
admet-373	468	8	m.	m.	NOUN
admet-373	468	9	allen	allen	PROPN
admet-373	468	10	,	,	PUNCT
admet-373	468	11	p.	p.	PROPN
admet-373	468	12	artursson	artursson	PROPN
admet-373	468	13	,	,	PUNCT
admet-373	468	14	m.m	m.m	PROPN
admet-373	468	15	.	.	PROPN
admet-373	468	16	hann	hann	PROPN
admet-373	468	17	,	,	PUNCT
admet-373	468	18	b.j	b.j	PROPN
admet-373	468	19	.	.	PROPN
admet-373	468	20	leavens	leaven	VERB
admet-373	468	21	,	,	PUNCT
admet-373	468	22	a.	a.	NOUN
admet-373	468	23	mateus	mateus	PROPN
admet-373	468	24	,	,	PUNCT
admet-373	468	25	et	et	PROPN
admet-373	468	26	al	al	PROPN
admet-373	468	27	.	.	PUNCT
admet-373	468	28	j.	j.	PROPN
admet-373	468	29	biomol	biomol	PROPN
admet-373	468	30	.	.	PUNCT
admet-373	469	1	screen	screen	NOUN
admet-373	469	2	.	.	PUNCT
admet-373	470	1	21(2	21(2	NUM
admet-373	470	2	)	)	PUNCT
admet-373	470	3	(	(	PUNCT
admet-373	470	4	2016	2016	NUM
admet-373	470	5	)	)	PUNCT
admet-373	470	6	156–164	156–164	NUM
admet-373	470	7	.	.	PUNCT
admet-373	471	1	[	[	X
admet-373	471	2	49	49	NUM
admet-373	471	3	]	]	X
admet-373	471	4	k.m	k.m	PROPN
admet-373	471	5	.	.	PROPN
admet-373	471	6	page	page	PROPN
admet-373	471	7	.	.	PUNCT
admet-373	472	1	mol	mol	PROPN
admet-373	472	2	.	.	PUNCT
admet-373	472	3	pharm	pharm	PROPN
admet-373	472	4	.	.	PUNCT
admet-373	473	1	13(2	13(2	NOUN
admet-373	473	2	)	)	PUNCT
admet-373	473	3	(	(	PUNCT
admet-373	473	4	2016	2016	NUM
admet-373	473	5	)	)	PUNCT
admet-373	473	6	609	609	NUM
admet-373	473	7	-	-	SYM
admet-373	473	8	620	620	NUM
admet-373	473	9	.	.	PUNCT
admet-373	474	1	[	[	X
admet-373	474	2	50	50	NUM
admet-373	474	3	]	]	PUNCT
admet-373	474	4	k.	k.	PROPN
admet-373	474	5	tam	tam	PROPN
admet-373	474	6	.	.	PROPN
admet-373	475	1	admet	admet	PROPN
admet-373	475	2	dmpk	dmpk	PROPN
admet-373	475	3	1(4	1(4	NUM
admet-373	475	4	)	)	PUNCT
admet-373	475	5	(	(	PUNCT
admet-373	475	6	2013	2013	NUM
admet-373	475	7	)	)	PUNCT
admet-373	475	8	63–75	63–75	NUM
admet-373	475	9	.	.	PUNCT
admet-373	476	1	[	[	X
admet-373	476	2	51	51	NUM
admet-373	476	3	]	]	PUNCT
admet-373	476	4	k.	k.	PROPN
admet-373	476	5	valko	valko	PROPN
admet-373	476	6	,	,	PUNCT
admet-373	476	7	e.	e.	PROPN
admet-373	476	8	chiarparin	chiarparin	PROPN
admet-373	476	9	,	,	PUNCT
admet-373	476	10	s.	s.	PROPN
admet-373	476	11	nunhuck	nunhuck	PROPN
admet-373	476	12	,	,	PUNCT
admet-373	476	13	d.	d.	PROPN
admet-373	476	14	montanari	montanari	PROPN
admet-373	476	15	.	.	PUNCT
admet-373	477	1	j.	j.	PROPN
admet-373	477	2	pharm	pharm	PROPN
admet-373	477	3	.	.	PUNCT
admet-373	478	1	sci	sci	PROPN
admet-373	478	2	.	.	PROPN
admet-373	479	1	101(11	101(11	NUM
admet-373	479	2	)	)	PUNCT
admet-373	479	3	(	(	PUNCT
admet-373	479	4	2012	2012	NUM
admet-373	479	5	)	)	PUNCT
admet-373	479	6	4155–4169	4155–4169	NUM
admet-373	479	7	.	.	PUNCT
admet-373	480	1	[	[	X
admet-373	480	2	52	52	NUM
admet-373	480	3	]	]	PUNCT
admet-373	480	4	k.	k.	PROPN
admet-373	480	5	valko	valko	PROPN
admet-373	480	6	,	,	PUNCT
admet-373	480	7	c.m	c.m	PROPN
admet-373	480	8	.	.	PROPN
admet-373	480	9	du	du	PROPN
admet-373	480	10	,	,	PUNCT
admet-373	480	11	c.d	c.d	PROPN
admet-373	480	12	.	.	PROPN
admet-373	480	13	bevan	bevan	PROPN
admet-373	480	14	,	,	PUNCT
admet-373	480	15	d.p	d.p	PROPN
admet-373	480	16	.	.	PROPN
admet-373	480	17	reynolds	reynolds	PROPN
admet-373	480	18	,	,	PUNCT
admet-373	480	19	m.h	m.h	PROPN
admet-373	480	20	.	.	PROPN
admet-373	480	21	abraham	abraham	PROPN
admet-373	480	22	,	,	PUNCT
admet-373	480	23	j.	j.	PROPN
admet-373	480	24	pharm	pharm	PROPN
admet-373	480	25	.	.	PUNCT
admet-373	481	1	sci	sci	PROPN
admet-373	481	2	.	.	PUNCT
admet-373	481	3	89(8	89(8	PROPN
admet-373	481	4	)	)	PUNCT
admet-373	481	5	(	(	PUNCT
admet-373	481	6	2000	2000	NUM
admet-373	481	7	)	)	PUNCT
admet-373	481	8	1085	1085	NUM
admet-373	481	9	-	-	SYM
admet-373	481	10	1096	1096	NUM
admet-373	481	11	.	.	PUNCT
admet-373	482	1	[	[	X
admet-373	482	2	53	53	NUM
admet-373	482	3	]	]	PUNCT
admet-373	482	4	g.	g.	PROPN
admet-373	482	5	russo	russo	PROPN
admet-373	482	6	,	,	PUNCT
admet-373	482	7	l.	l.	PROPN
admet-373	482	8	grumetto	grumetto	PROPN
admet-373	482	9	,	,	PUNCT
admet-373	482	10	f.	f.	PROPN
admet-373	482	11	barbato	barbato	PROPN
admet-373	482	12	,	,	PUNCT
admet-373	482	13	g.	g.	PROPN
admet-373	482	14	vistoli	vistoli	PROPN
admet-373	482	15	,	,	PUNCT
admet-373	482	16	a.	a.	NOUN
admet-373	482	17	pedretti	pedretti	PROPN
admet-373	482	18	.	.	PUNCT
admet-373	483	1	eur	eur	PROPN
admet-373	483	2	.	.	PUNCT
admet-373	484	1	j.	j.	PROPN
admet-373	484	2	pharm	pharm	PROPN
admet-373	484	3	.	.	PUNCT
admet-373	485	1	sci	sci	PROPN
admet-373	485	2	.	.	PROPN
admet-373	486	1	99	99	NUM
admet-373	486	2	(	(	PUNCT
admet-373	486	3	2017	2017	NUM
admet-373	486	4	)	)	PUNCT
admet-373	487	1	173–184	173–184	NUM
admet-373	487	2	.	.	PUNCT
admet-373	488	1	[	[	X
admet-373	488	2	54	54	NUM
admet-373	488	3	]	]	X
admet-373	488	4	g.	g.	PROPN
admet-373	488	5	colmenarejo	colmenarejo	PROPN
admet-373	488	6	.	.	PROPN
admet-373	488	7	med	med	PROPN
admet-373	488	8	.	.	PUNCT
admet-373	489	1	res	re	NOUN
admet-373	489	2	.	.	PUNCT
admet-373	490	1	rev	rev	PROPN
admet-373	490	2	.	.	PROPN
admet-373	490	3	23(3	23(3	NUM
admet-373	490	4	)	)	PUNCT
admet-373	490	5	(	(	PUNCT
admet-373	490	6	2003	2003	NUM
admet-373	490	7	)	)	PUNCT
admet-373	491	1	275–301	275–301	NUM
admet-373	491	2	.	.	PUNCT
admet-373	492	1	[	[	X
admet-373	492	2	55	55	NUM
admet-373	492	3	]	]	X
admet-373	492	4	g.	g.	PROPN
admet-373	492	5	lambrinidis	lambrinidis	PROPN
admet-373	492	6	,	,	PUNCT
admet-373	492	7	t.	t.	NOUN
admet-373	492	8	vallianatou	vallianatou	PROPN
admet-373	492	9	,	,	PUNCT
admet-373	492	10	a.	a.	NOUN
admet-373	492	11	tsantili	tsantili	NOUN
admet-373	492	12	-	-	PUNCT
admet-373	492	13	kakoulidou	kakoulidou	NOUN
admet-373	492	14	.	.	PUNCT
admet-373	493	1	adv	adv	PROPN
admet-373	493	2	.	.	PUNCT
admet-373	493	3	drug	drug	PROPN
admet-373	493	4	deliv	deliv	PROPN
admet-373	493	5	.	.	PUNCT
admet-373	494	1	rev	rev	PROPN
admet-373	494	2	.	.	PROPN
admet-373	494	3	86	86	NUM
admet-373	494	4	(	(	PUNCT
admet-373	494	5	2015	2015	NUM
admet-373	494	6	)	)	PUNCT
admet-373	494	7	27–45	27–45	NUM
admet-373	494	8	.	.	PUNCT
admet-373	495	1	[	[	X
admet-373	495	2	56	56	NUM
admet-373	495	3	]	]	X
admet-373	495	4	p.n	p.n	PROPN
admet-373	495	5	.	.	PROPN
admet-373	495	6	mortenson	mortenson	PROPN
admet-373	495	7	,	,	PUNCT
admet-373	495	8	c.w	c.w	PROPN
admet-373	495	9	.	.	PROPN
admet-373	495	10	murray	murray	PROPN
admet-373	495	11	.	.	PUNCT
admet-373	496	1	j.	j.	PROPN
admet-373	496	2	comput	comput	PROPN
admet-373	496	3	.	.	PUNCT
admet-373	496	4	aided	aid	VERB
admet-373	496	5	mol	mol	PROPN
admet-373	496	6	.	.	PUNCT
admet-373	497	1	des	des	PROPN
admet-373	497	2	.	.	PROPN
admet-373	497	3	25(7	25(7	NUM
admet-373	497	4	)	)	PUNCT
admet-373	497	5	(	(	PUNCT
admet-373	497	6	2011	2011	NUM
admet-373	497	7	)	)	PUNCT
admet-373	498	1	663–667	663–667	NUM
admet-373	498	2	.	.	PUNCT
admet-373	499	1	[	[	X
admet-373	499	2	57	57	NUM
admet-373	499	3	]	]	X
admet-373	499	4	u.m	u.m	PROPN
admet-373	499	5	.	.	PROPN
admet-373	499	6	hanumegowda	hanumegowda	PROPN
admet-373	499	7	,	,	PUNCT
admet-373	499	8	g.	g.	PROPN
admet-373	499	9	wenke	wenke	NOUN
admet-373	499	10	,	,	PUNCT
admet-373	499	11	a.	a.	NOUN
admet-373	499	12	regueiro	regueiro	NOUN
admet-373	499	13	-	-	PUNCT
admet-373	499	14	ren	ren	PROPN
admet-373	499	15	,	,	PUNCT
admet-373	499	16	r.	r.	PROPN
admet-373	499	17	yordanova	yordanova	PROPN
admet-373	499	18	,	,	PUNCT
admet-373	499	19	j.p	j.p	PROPN
admet-373	499	20	.	.	PROPN
admet-373	499	21	corradi	corradi	PROPN
admet-373	499	22	,	,	PUNCT
admet-373	499	23	s.p	s.p	PROPN
admet-373	499	24	.	.	PROPN
admet-373	499	25	adams	adams	PROPN
admet-373	499	26	.	.	PUNCT
admet-373	499	27	chem	chem	PROPN
admet-373	499	28	.	.	PUNCT
admet-373	500	1	res	re	NOUN
admet-373	500	2	.	.	PUNCT
admet-373	501	1	toxicol	toxicol	PROPN
admet-373	501	2	.	.	PUNCT
admet-373	502	1	23(4	23(4	NOUN
admet-373	502	2	)	)	PUNCT
admet-373	502	3	(	(	PUNCT
admet-373	502	4	2010	2010	NUM
admet-373	502	5	)	)	PUNCT
admet-373	503	1	749–755	749–755	NUM
admet-373	503	2	.	.	PUNCT
admet-373	504	1	[	[	X
admet-373	504	2	58	58	NUM
admet-373	504	3	]	]	X
admet-373	504	4	d.	d.	PROPN
admet-373	504	5	price	price	PROPN
admet-373	504	6	,	,	PUNCT
admet-373	504	7	j.	j.	PROPN
admet-373	504	8	blagg	blagg	PROPN
admet-373	504	9	,	,	PUNCT
admet-373	504	10	l.	l.	PROPN
admet-373	504	11	jones	jones	PROPN
admet-373	504	12	,	,	PUNCT
admet-373	504	13	n.	n.	PROPN
admet-373	504	14	greene	greene	PROPN
admet-373	504	15	,	,	PUNCT
admet-373	504	16	t.	t.	NOUN
admet-373	504	17	wager	wager	NOUN
admet-373	504	18	.	.	PUNCT
admet-373	505	1	expert	expert	NOUN
admet-373	505	2	opin	opin	NOUN
admet-373	505	3	.	.	PUNCT
admet-373	506	1	drug	drug	NOUN
admet-373	506	2	metab	metab	NOUN
admet-373	506	3	.	.	PUNCT
admet-373	507	1	toxicol	toxicol	PROPN
admet-373	507	2	.	.	PUNCT
admet-373	508	1	5(8	5(8	NUM
admet-373	508	2	)	)	PUNCT
admet-373	508	3	(	(	PUNCT
admet-373	508	4	2009	2009	NUM
admet-373	508	5	)	)	PUNCT
admet-373	508	6	921	921	NUM
admet-373	508	7	–	–	PUNCT
admet-373	508	8	931	931	NUM
admet-373	508	9	.	.	PUNCT
admet-373	509	1	[	[	X
admet-373	509	2	59	59	NUM
admet-373	509	3	]	]	PUNCT
admet-373	509	4	a.	a.	NOUN
admet-373	509	5	casartelli	casartelli	PROPN
admet-373	509	6	,	,	PUNCT
admet-373	509	7	a.	a.	PROPN
admet-373	509	8	lanzoni	lanzoni	PROPN
admet-373	509	9	,	,	PUNCT
admet-373	509	10	r.	r.	PROPN
admet-373	509	11	comelli	comelli	PROPN
admet-373	509	12	,	,	PUNCT
admet-373	509	13	f.	f.	PROPN
admet-373	509	14	crivellente	crivellente	PROPN
admet-373	509	15	,	,	PUNCT
admet-373	509	16	r.	r.	PROPN
admet-373	509	17	defazio	defazio	PROPN
admet-373	509	18	,	,	PUNCT
admet-373	509	19	r.	r.	PROPN
admet-373	509	20	dorigatti	dorigatti	PROPN
admet-373	509	21	,	,	PUNCT
admet-373	510	1	et	et	PROPN
admet-373	510	2	al	al	PROPN
admet-373	510	3	.	.	PROPN
admet-373	511	1	toxicol	toxicol	PROPN
admet-373	511	2	.	.	PUNCT
admet-373	512	1	pathol	pathol	PROPN
admet-373	512	2	.	.	PUNCT
admet-373	513	1	39(2	39(2	X
admet-373	513	2	)	)	PUNCT
admet-373	513	3	(	(	PUNCT
admet-373	513	4	2011	2011	NUM
admet-373	513	5	)	)	PUNCT
admet-373	514	1	361–371	361–371	NUM
admet-373	514	2	.	.	PUNCT
admet-373	515	1	[	[	X
admet-373	515	2	60	60	NUM
admet-373	515	3	]	]	X
admet-373	515	4	l.j	l.j	PROPN
admet-373	515	5	.	.	PROPN
admet-373	515	6	gordon	gordon	PROPN
admet-373	515	7	,	,	PUNCT
admet-373	515	8	m.	m.	NOUN
admet-373	515	9	allen	allen	PROPN
admet-373	515	10	,	,	PUNCT
admet-373	515	11	p.	p.	PROPN
admet-373	515	12	artursson	artursson	PROPN
admet-373	515	13	,	,	PUNCT
admet-373	515	14	m.m	m.m	PROPN
admet-373	515	15	.	.	PROPN
admet-373	515	16	hann	hann	PROPN
admet-373	515	17	,	,	PUNCT
admet-373	515	18	b.j	b.j	PROPN
admet-373	515	19	.	.	PROPN
admet-373	515	20	leavens	leaven	VERB
admet-373	515	21	,	,	PUNCT
admet-373	515	22	a.	a.	NOUN
admet-373	515	23	mateus	mateus	PROPN
admet-373	515	24	,	,	PUNCT
admet-373	515	25	et	et	PROPN
admet-373	515	26	al	al	PROPN
admet-373	515	27	.	.	PUNCT
admet-373	515	28	j.	j.	PROPN
admet-373	515	29	biomol	biomol	PROPN
admet-373	515	30	.	.	PUNCT
admet-373	516	1	screen	screen	NOUN
admet-373	516	2	.	.	PUNCT
admet-373	517	1	21(2	21(2	NUM
admet-373	517	2	)	)	PUNCT
admet-373	517	3	2016	2016	NUM
admet-373	517	4	156	156	NUM
admet-373	517	5	-	-	SYM
admet-373	517	6	164	164	NUM
admet-373	517	7	.	.	PUNCT
admet-373	518	1	[	[	X
admet-373	518	2	61	61	NUM
admet-373	518	3	]	]	X
admet-373	518	4	d.	d.	PROPN
admet-373	518	5	stepensky	stepensky	PROPN
admet-373	518	6	.	.	PUNCT
admet-373	519	1	expert	expert	NOUN
admet-373	519	2	opin	opin	NOUN
admet-373	519	3	.	.	PUNCT
admet-373	520	1	drug	drug	NOUN
admet-373	520	2	metab	metab	NOUN
admet-373	520	3	.	.	PUNCT
admet-373	521	1	toxicol	toxicol	PROPN
admet-373	521	2	.	.	PUNCT
admet-373	522	1	7(10	7(10	NUM
admet-373	522	2	)	)	PUNCT
admet-373	522	3	(	(	PUNCT
admet-373	522	4	2011	2011	NUM
admet-373	522	5	)	)	PUNCT
admet-373	522	6	1233–1243	1233–1243	NUM
admet-373	522	7	.	.	PUNCT
admet-373	523	1	[	[	X
admet-373	523	2	62	62	NUM
admet-373	523	3	]	]	PUNCT
admet-373	523	4	r.	r.	PROPN
admet-373	523	5	kaliszan	kaliszan	PROPN
admet-373	523	6	,	,	PUNCT
admet-373	523	7	a.	a.	NOUN
admet-373	523	8	nasal	nasal	PROPN
admet-373	523	9	,	,	PUNCT
admet-373	523	10	m.	m.	NOUN
admet-373	523	11	turowski	turowski	PROPN
admet-373	523	12	.	.	PUNCT
admet-373	523	13	biomed	biome	VERB
admet-373	523	14	.	.	PUNCT
admet-373	524	1	chromatogr	chromatogr	NOUN
admet-373	524	2	.	.	PUNCT
admet-373	525	1	9(5	9(5	NUM
admet-373	525	2	)	)	PUNCT
admet-373	525	3	(	(	PUNCT
admet-373	525	4	1995	1995	NUM
admet-373	525	5	)	)	PUNCT
admet-373	526	1	211–215	211–215	NUM
admet-373	526	2	.	.	PUNCT
admet-373	527	1	[	[	X
admet-373	527	2	63	63	NUM
admet-373	527	3	]	]	PUNCT
admet-373	527	4	t.	t.	NOUN
admet-373	527	5	fournier	fournier	NOUN
admet-373	527	6	,	,	PUNCT
admet-373	527	7	n.	n.	PROPN
admet-373	527	8	medjoubi	medjoubi	PROPN
admet-373	527	9	,	,	PUNCT
admet-373	527	10	d.	d.	PROPN
admet-373	527	11	porquet	porquet	PROPN
admet-373	527	12	.	.	PUNCT
admet-373	528	1	biochim	biochim	PROPN
admet-373	528	2	.	.	PUNCT
admet-373	529	1	biophys	biophy	NOUN
admet-373	529	2	.	.	PUNCT
admet-373	530	1	acta	acta	PROPN
admet-373	530	2	1482	1482	NUM
admet-373	530	3	(	(	PUNCT
admet-373	530	4	2000	2000	NUM
admet-373	530	5	)	)	PUNCT
admet-373	530	6	157–171	157–171	NUM
admet-373	530	7	.	.	PUNCT
admet-373	531	1	[	[	X
admet-373	531	2	64	64	NUM
admet-373	531	3	]	]	PUNCT
admet-373	531	4	k.	k.	PROPN
admet-373	531	5	valko	valko	PROPN
admet-373	531	6	.	.	PUNCT
admet-373	532	1	physicochemical	physicochemical	ADJ
admet-373	532	2	and	and	CCONJ
admet-373	532	3	biomimetic	biomimetic	ADJ
admet-373	532	4	properties	property	NOUN
admet-373	532	5	in	in	ADP
admet-373	532	6	drug	drug	NOUN
admet-373	532	7	discovery	discovery	NOUN
admet-373	532	8	:	:	PUNCT
admet-373	532	9	chromatographic	chromatographic	ADJ
admet-373	532	10	techniques	technique	NOUN
admet-373	532	11	for	for	ADP
admet-373	532	12	lead	lead	ADJ
admet-373	532	13	optimization	optimization	NOUN
admet-373	532	14	.	.	PUNCT
admet-373	533	1	wiley	wiley	PROPN
admet-373	533	2	hoboken	hoboken	PROPN
admet-373	533	3	nj	nj	PROPN
admet-373	533	4	,	,	PUNCT
admet-373	533	5	(	(	PUNCT
admet-373	533	6	2014	2014	NUM
admet-373	533	7	)	)	PUNCT
admet-373	533	8	,	,	PUNCT
admet-373	533	9	chapter	chapter	NOUN
admet-373	533	10	11	11	NUM
admet-373	533	11	,	,	PUNCT
admet-373	533	12	p.	p.	NOUN
admet-373	533	13	294	294	NUM
admet-373	533	14	-	-	SYM
admet-373	533	15	310	310	NUM
admet-373	533	16	.	.	PUNCT
admet-373	534	1	[	[	X
admet-373	534	2	65	65	NUM
admet-373	534	3	]	]	X
admet-373	534	4	f.	f.	PROPN
admet-373	534	5	zsila	zsila	PROPN
admet-373	534	6	.	.	PUNCT
admet-373	535	1	curr	curr	PROPN
admet-373	535	2	.	.	PUNCT
admet-373	535	3	drug	drug	PROPN
admet-373	535	4	metab	metab	NOUN
admet-373	535	5	.	.	PUNCT
admet-373	536	1	8	8	NUM
admet-373	536	2	(	(	PUNCT
admet-373	536	3	2007	2007	NUM
admet-373	536	4	)	)	PUNCT
admet-373	537	1	563–593	563–593	NUM
admet-373	537	2	.	.	PUNCT
admet-373	538	1	[	[	X
admet-373	538	2	66	66	NUM
admet-373	538	3	]	]	PUNCT
admet-373	538	4	k.	k.	PROPN
admet-373	538	5	valko	valko	PROPN
admet-373	538	6	.	.	PUNCT
admet-373	539	1	physicochemical	physicochemical	ADJ
admet-373	539	2	and	and	CCONJ
admet-373	539	3	biomimetic	biomimetic	ADJ
admet-373	539	4	properties	property	NOUN
admet-373	539	5	in	in	ADP
admet-373	539	6	drug	drug	NOUN
admet-373	539	7	discovery	discovery	NOUN
admet-373	539	8	:	:	PUNCT
admet-373	539	9	chromatographic	chromatographic	ADJ
admet-373	539	10	techniques	technique	NOUN
admet-373	539	11	for	for	ADP
admet-373	539	12	lead	lead	ADJ
admet-373	539	13	optimization	optimization	NOUN
admet-373	539	14	.	.	PUNCT
admet-373	540	1	wiley	wiley	PROPN
admet-373	540	2	hoboken	hoboken	PROPN
admet-373	540	3	nj	nj	PROPN
admet-373	540	4	,	,	PUNCT
admet-373	540	5	(	(	PUNCT
admet-373	540	6	2014	2014	NUM
admet-373	540	7	)	)	PUNCT
admet-373	540	8	chapter	chapter	NOUN
admet-373	540	9	11	11	NUM
admet-373	540	10	,	,	PUNCT
admet-373	540	11	p.	p.	NOUN
admet-373	540	12	295	295	NUM
admet-373	540	13	.	.	PUNCT
admet-373	541	1	[	[	X
admet-373	541	2	67	67	NUM
admet-373	541	3	]	]	PUNCT
admet-373	541	4	k.	k.	PROPN
admet-373	541	5	valko	valko	PROPN
admet-373	541	6	.	.	PUNCT
admet-373	542	1	physicochemical	physicochemical	ADJ
admet-373	542	2	and	and	CCONJ
admet-373	542	3	biomimetic	biomimetic	ADJ
admet-373	542	4	properties	property	NOUN
admet-373	542	5	in	in	ADP
admet-373	542	6	drug	drug	NOUN
admet-373	542	7	discovery	discovery	NOUN
admet-373	542	8	:	:	PUNCT
admet-373	542	9	chromatographic	chromatographic	ADJ
admet-373	542	10	techniques	technique	NOUN
admet-373	542	11	for	for	ADP
admet-373	542	12	lead	lead	ADJ
admet-373	542	13	optimization	optimization	NOUN
admet-373	542	14	.	.	PUNCT
admet-373	543	1	wiley	wiley	PROPN
admet-373	543	2	hoboken	hoboken	PROPN
admet-373	543	3	nj	nj	PROPN
admet-373	543	4	,	,	PUNCT
admet-373	543	5	(	(	PUNCT
admet-373	543	6	2014	2014	NUM
admet-373	543	7	)	)	PUNCT
admet-373	543	8	,	,	PUNCT
admet-373	543	9	chapter	chapter	NOUN
admet-373	543	10	11	11	NUM
admet-373	543	11	,	,	PUNCT
admet-373	543	12	p.	p.	NOUN
admet-373	543	13	296	296	NUM
admet-373	543	14	.	.	PUNCT
admet-373	544	1	admet	admet	PROPN
admet-373	544	2	&	&	CCONJ
admet-373	544	3	dmpk	dmpk	PROPN
admet-373	544	4	5(1	5(1	NUM
admet-373	544	5	)	)	PUNCT
admet-373	544	6	(	(	PUNCT
admet-373	544	7	2017	2017	NUM
admet-373	544	8	)	)	PUNCT
admet-373	544	9	14	14	NUM
admet-373	544	10	-	-	SYM
admet-373	544	11	38	38	NUM
admet-373	544	12	in	in	ADP
admet-373	544	13	vitro	vitro	X
admet-373	544	14	membrane	membrane	NOUN
admet-373	544	15	and	and	CCONJ
admet-373	544	16	protein	protein	NOUN
admet-373	544	17	binding	bind	VERB
admet-373	544	18	doi	doi	NOUN
admet-373	544	19	:	:	PUNCT
admet-373	544	20	10.5599	10.5599	NUM
admet-373	544	21	/	/	SYM
admet-373	544	22	admet.5.1.373	admet.5.1.373	CCONJ
admet-373	544	23	31	31	NUM
admet-373	544	24	appendix	appendix	NOUN
admet-373	544	25	table	table	NOUN
admet-373	544	26	a1	a1	NOUN
admet-373	544	27	.	.	PUNCT
admet-373	545	1	the	the	DET
admet-373	545	2	in	in	ADP
admet-373	545	3	vivo	vivo	ADJ
admet-373	545	4	human	human	ADJ
admet-373	545	5	data	datum	NOUN
admet-373	545	6	for	for	ADP
admet-373	545	7	the	the	DET
admet-373	545	8	investigated	investigate	VERB
admet-373	545	9	marketed	market	VERB
admet-373	545	10	drugs	drug	NOUN
admet-373	545	11	.	.	PUNCT
admet-373	546	1	training	training	NOUN
admet-373	546	2	set	set	NOUN
admet-373	546	3	marked	mark	VERB
admet-373	546	4	from	from	ADP
admet-373	546	5	the	the	DET
admet-373	546	6	vd	vd	NOUN
admet-373	546	7	model	model	NOUN
admet-373	546	8	[	[	X
admet-373	546	9	42	42	NUM
admet-373	546	10	]	]	PUNCT
admet-373	546	11	.	.	PUNCT
admet-373	547	1	drug	drug	PROPN
admet-373	547	2	te	te	PROPN
admet-373	547	3	st	st	PROPN
admet-373	547	4	s	s	PROPN
admet-373	547	5	e	e	PROPN
admet-373	547	6	t	t	PROPN
admet-373	547	7	/	/	PUNCT
admet-373	547	8	tr	tr	VERB
admet-373	547	9	ai	ai	VERB
admet-373	547	10	n	n	ADV
admet-373	547	11	in	in	ADP
admet-373	547	12	g	g	PROPN
admet-373	547	13	se	se	PROPN
admet-373	547	14	t	t	PROPN
admet-373	548	1	a	a	DET
admet-373	548	2	ct	ct	PROPN
admet-373	548	3	u	u	NOUN
admet-373	548	4	al	al	PROPN
admet-373	548	5	d	d	PROPN
admet-373	548	6	ai	ai	VERB
admet-373	548	7	ly	ly	X
admet-373	548	8	d	d	X
admet-373	548	9	o	o	X
admet-373	548	10	se	se	X
admet-373	548	11	pic	pic	PROPN
admet-373	549	1	50	50	NUM
admet-373	549	2	d	d	NOUN
admet-373	549	3	o	o	X
admet-373	549	4	si	si	X
admet-373	549	5	n	n	CCONJ
admet-373	549	6	g	g	PROPN
admet-373	549	7	/	/	SYM
admet-373	549	8	d	d	NOUN
admet-373	549	9	ay	ay	NOUN
admet-373	549	10	in	in	ADP
admet-373	549	11	v	v	NUM
admet-373	549	12	iv	iv	NOUN
admet-373	549	13	o	o	NOUN
admet-373	549	14	h	h	NOUN
admet-373	549	15	u	u	NOUN
admet-373	549	16	m	m	VERB
admet-373	549	17	an	an	DET
admet-373	549	18	v	v	NOUN
admet-373	549	19	d	d	X
admet-373	549	20	ss	ss	NOUN
admet-373	549	21	(	(	PUNCT
admet-373	549	22	l/	l/	PROPN
admet-373	549	23	kg	kg	NOUN
admet-373	549	24	)	)	PUNCT
admet-373	550	1	in	in	ADP
admet-373	550	2	v	v	NUM
admet-373	550	3	iv	iv	NUM
admet-373	550	4	o	o	NOUN
admet-373	551	1	lo	lo	NOUN
admet-373	552	1	g	g	NOUN
admet-373	552	2	v	v	PROPN
admet-373	552	3	d	d	X
admet-373	552	4	ss	ss	NOUN
admet-373	552	5	in	in	ADP
admet-373	552	6	v	v	NUM
admet-373	552	7	iv	iv	NOUN
admet-373	552	8	o	o	NOUN
admet-373	552	9	v	v	NOUN
admet-373	552	10	d	d	X
admet-373	552	11	u	u	NOUN
admet-373	552	12	(	(	PUNCT
admet-373	552	13	l	l	NOUN
admet-373	552	14	/k	/k	PUNCT
admet-373	552	15	g	g	NOUN
admet-373	552	16	)	)	PUNCT
admet-373	552	17	in	in	ADP
admet-373	552	18	v	v	NUM
admet-373	553	1	iv	iv	NUM
admet-373	553	2	o	o	NOUN
admet-373	553	3	lo	lo	NOUN
admet-373	553	4	g	g	NOUN
admet-373	553	5	v	v	PROPN
admet-373	553	6	d	d	X
admet-373	553	7	u	u	NOUN
admet-373	553	8	in	in	ADP
admet-373	553	9	v	v	NUM
admet-373	553	10	iv	iv	NOUN
admet-373	554	1	o	o	NOUN
admet-373	554	2	c	c	NOUN
admet-373	554	3	l	l	PROPN
admet-373	554	4	m	m	VERB
admet-373	554	5	l/	l/	NOUN
admet-373	554	6	m	m	VERB
admet-373	554	7	in	in	ADP
admet-373	554	8	/k	/k	ADP
admet-373	554	9	g	g	NOUN
admet-373	554	10	in	in	ADP
admet-373	554	11	v	v	NUM
admet-373	555	1	iv	iv	NUM
admet-373	555	2	o	o	NOUN
admet-373	555	3	lo	lo	NOUN
admet-373	555	4	g	g	NOUN
admet-373	555	5	c	c	PROPN
admet-373	555	6	l	l	NOUN
admet-373	555	7	t1/2	t1/2	PROPN
admet-373	555	8	(	(	PUNCT
admet-373	555	9	h	h	NOUN
admet-373	555	10	)	)	PUNCT
admet-373	555	11	log	log	NOUN
admet-373	555	12	t1/2	t1/2	NOUN
admet-373	555	13	(	(	PUNCT
admet-373	555	14	h	h	NOUN
admet-373	555	15	)	)	PUNCT
admet-373	555	16	abacavir	abacavir	VERB
admet-373	555	17	test	test	VERB
admet-373	555	18	600	600	NUM
admet-373	555	19	7.2	7.2	NUM
admet-373	555	20	2	2	NUM
admet-373	555	21	0.84	0.84	NUM
admet-373	555	22	-0.08	-0.08	NUM
admet-373	555	23	1.68	1.68	NUM
admet-373	555	24	0.23	0.23	NUM
admet-373	555	25	13.00	13.00	NUM
admet-373	555	26	1.11	1.11	NUM
admet-373	555	27	1.00	1.00	NUM
admet-373	555	28	0.00	0.00	NUM
admet-373	555	29	acebutolol	acebutolol	NOUN
admet-373	555	30	hydrochloride	hydrochloride	NOUN
admet-373	555	31	test	test	NOUN
admet-373	555	32	400	400	NUM
admet-373	555	33	6.8	6.8	NUM
admet-373	555	34	2	2	NUM
admet-373	555	35	1.7	1.7	NUM
admet-373	555	36	0.23	0.23	NUM
admet-373	555	37	2.30	2.30	NUM
admet-373	555	38	0.36	0.36	NUM
admet-373	555	39	10.00	10.00	NUM
admet-373	555	40	1.00	1.00	NUM
admet-373	555	41	3.50	3.50	NUM
admet-373	555	42	0.54	0.54	NUM
admet-373	555	43	acetylsalicylic	acetylsalicylic	NOUN
admet-373	555	44	acid	acid	PROPN
admet-373	555	45	train	train	NOUN
admet-373	555	46	.	.	PUNCT
admet-373	556	1	1200	1200	NUM
admet-373	556	2	5.5	5.5	NUM
admet-373	556	3	3	3	NUM
admet-373	556	4	0.22	0.22	NUM
admet-373	556	5	-0.66	-0.66	NUM
admet-373	556	6	0.32	0.32	NUM
admet-373	556	7	-0.49	-0.49	ADP
admet-373	556	8	12.00	12.00	NUM
admet-373	556	9	1.08	1.08	NUM
admet-373	556	10	acrivastine	acrivastine	ADJ
admet-373	556	11	test	test	NOUN
admet-373	556	12	32	32	NUM
admet-373	556	13	8.5	8.5	NUM
admet-373	556	14	4	4	NUM
admet-373	556	15	1.50	1.50	NUM
admet-373	556	16	0.18	0.18	NUM
admet-373	556	17	albuterol	albuterol	NOUN
admet-373	556	18	sulfate	sulfate	NOUN
admet-373	556	19	test	test	NOUN
admet-373	556	20	8	8	NUM
admet-373	556	21	7.4	7.4	NUM
admet-373	556	22	4	4	NUM
admet-373	556	23	1.9	1.9	NUM
admet-373	556	24	0.28	0.28	NUM
admet-373	556	25	2.07	2.07	NUM
admet-373	556	26	0.31	0.31	NUM
admet-373	556	27	7.80	7.80	NUM
admet-373	556	28	0.89	0.89	NUM
admet-373	556	29	2.40	2.40	NUM
admet-373	556	30	0.38	0.38	NUM
admet-373	556	31	allopurinol	allopurinol	NOUN
admet-373	556	32	test	test	NOUN
admet-373	556	33	300	300	NUM
admet-373	556	34	5.3	5.3	NUM
admet-373	556	35	1	1	NUM
admet-373	556	36	0.58	0.58	NUM
admet-373	556	37	-0.24	-0.24	NUM
admet-373	556	38	0.60	0.60	NUM
admet-373	556	39	-0.22	-0.22	NUM
admet-373	556	40	11.00	11.00	NUM
admet-373	556	41	1.04	1.04	NUM
admet-373	556	42	0.80	0.80	NUM
admet-373	556	43	-0.10	-0.10	PRON
admet-373	556	44	alosetron	alosetron	ADJ
admet-373	556	45	hydrochloride	hydrochloride	NOUN
admet-373	556	46	train	train	NOUN
admet-373	556	47	.	.	PUNCT
admet-373	557	1	1	1	NUM
admet-373	557	2	7.3	7.3	NUM
admet-373	557	3	2	2	NUM
admet-373	557	4	1.1	1.1	NUM
admet-373	557	5	0.04	0.04	NUM
admet-373	557	6	6.11	6.11	NUM
admet-373	557	7	0.79	0.79	NUM
admet-373	557	8	8.70	8.70	NUM
admet-373	557	9	0.94	0.94	NUM
admet-373	557	10	1.60	1.60	NUM
admet-373	557	11	0.20	0.20	NUM
admet-373	557	12	amiloride	amiloride	ADJ
admet-373	557	13	hydrochloride	hydrochloride	NOUN
admet-373	557	14	test	test	NOUN
admet-373	557	15	5	5	NUM
admet-373	557	16	5.5	5.5	NUM
admet-373	557	17	1	1	NUM
admet-373	557	18	5	5	NUM
admet-373	557	19	0.70	0.70	NUM
admet-373	557	20	7.50	7.50	NUM
admet-373	557	21	0.88	0.88	NUM
admet-373	557	22	aminoglutethimide	aminoglutethimide	ADJ
admet-373	557	23	test	test	NOUN
admet-373	557	24	500	500	NUM
admet-373	557	25	4.9	4.9	NUM
admet-373	557	26	2	2	NUM
admet-373	557	27	12.50	12.50	NUM
admet-373	557	28	1.10	1.10	NUM
admet-373	557	29	amitriptyline	amitriptyline	NOUN
admet-373	557	30	hydrochloride	hydrochloride	NOUN
admet-373	557	31	test	test	NOUN
admet-373	558	1	50	50	NUM
admet-373	558	2	6.2	6.2	NUM
admet-373	558	3	1	1	NUM
admet-373	558	4	8.7	8.7	NUM
admet-373	558	5	0.94	0.94	NUM
admet-373	558	6	124.29	124.29	NUM
admet-373	558	7	2.09	2.09	NUM
admet-373	558	8	6.10	6.10	NUM
admet-373	558	9	0.79	0.79	NUM
admet-373	558	10	17.00	17.00	NUM
admet-373	558	11	1.23	1.23	NUM
admet-373	558	12	amoxapine	amoxapine	NOUN
admet-373	558	13	train	train	NOUN
admet-373	558	14	.	.	PUNCT
admet-373	559	1	300	300	NUM
admet-373	559	2	6.5	6.5	NUM
admet-373	559	3	3	3	NUM
admet-373	559	4	aripiprazole	aripiprazole	NOUN
admet-373	559	5	test	test	NOUN
admet-373	559	6	10	10	NUM
admet-373	559	7	9.7	9.7	NUM
admet-373	559	8	1	1	NUM
admet-373	559	9	4.9	4.9	NUM
admet-373	559	10	0.69	0.69	NUM
admet-373	559	11	490.00	490.00	NUM
admet-373	559	12	2.69	2.69	NUM
admet-373	559	13	0.83	0.83	NUM
admet-373	559	14	-0.08	-0.08	NUM
admet-373	559	15	75.00	75.00	NUM
admet-373	559	16	1.88	1.88	NUM
admet-373	559	17	atomoxetine	atomoxetine	NOUN
admet-373	559	18	hydrochloride1	hydrochloride1	NOUN
admet-373	559	19	test	test	NOUN
admet-373	559	20	40	40	NUM
admet-373	559	21	8.7	8.7	NUM
admet-373	559	22	1	1	NUM
admet-373	559	23	0.85	0.85	NUM
admet-373	559	24	-0.07	-0.07	NUM
admet-373	559	25	42.50	42.50	NUM
admet-373	559	26	1.63	1.63	NUM
admet-373	559	27	9.30	9.30	NUM
admet-373	559	28	0.97	0.97	NUM
admet-373	559	29	5.20	5.20	NUM
admet-373	559	30	0.72	0.72	NUM
admet-373	559	31	bendroflumethiazide	bendroflumethiazide	NOUN
admet-373	559	32	test	test	NOUN
admet-373	559	33	3	3	NUM
admet-373	559	34	3.4	3.4	NUM
admet-373	559	35	1	1	NUM
admet-373	559	36	8.50	8.50	NUM
admet-373	559	37	0.93	0.93	NUM
admet-373	559	38	bicalutamide	bicalutamide	NOUN
admet-373	559	39	test	test	NOUN
admet-373	559	40	50	50	NUM
admet-373	559	41	6.1	6.1	NUM
admet-373	559	42	1	1	NUM
admet-373	559	43	144.00	144.00	NUM
admet-373	559	44	2.16	2.16	NUM
admet-373	559	45	bupropion	bupropion	NOUN
admet-373	559	46	hydrochloride	hydrochloride	NOUN
admet-373	559	47	test	test	NOUN
admet-373	559	48	300	300	NUM
admet-373	559	49	6.3	6.3	NUM
admet-373	559	50	1	1	NUM
admet-373	559	51	24.00	24.00	NUM
admet-373	559	52	1.38	1.38	NUM
admet-373	559	53	cabergoline	cabergoline	NOUN
admet-373	559	54	test	test	NOUN
admet-373	559	55	0	0	NUM
admet-373	559	56	10	10	NUM
admet-373	559	57	0	0	NUM
admet-373	559	58	45.71	45.71	NUM
admet-373	559	59	1.66	1.66	NUM
admet-373	559	60	65.00	65.00	NUM
admet-373	559	61	1.81	1.81	NUM
admet-373	559	62	caffeine	caffeine	NOUN
admet-373	559	63	test	test	NOUN
admet-373	559	64	150	150	NUM
admet-373	559	65	4.7	4.7	NUM
admet-373	559	66	3	3	NUM
admet-373	559	67	0.63	0.63	NUM
admet-373	559	68	-0.20	-0.20	NUM
admet-373	559	69	0.98	0.98	NUM
admet-373	559	70	-0.01	-0.01	NUM
admet-373	559	71	1.40	1.40	NUM
admet-373	559	72	0.15	0.15	NUM
admet-373	559	73	4.90	4.90	NUM
admet-373	559	74	0.69	0.69	NUM
admet-373	559	75	candesartan	candesartan	PROPN
admet-373	559	76	cilexetil	cilexetil	PROPN
admet-373	559	77	test	test	NOUN
admet-373	559	78	8	8	NUM
admet-373	559	79	10.5	10.5	NUM
admet-373	559	80	1	1	NUM
admet-373	559	81	0.13	0.13	NUM
admet-373	559	82	-0.89	-0.89	NUM
admet-373	559	83	13.00	13.00	NUM
admet-373	559	84	1.11	1.11	NUM
admet-373	559	85	0.37	0.37	NUM
admet-373	559	86	-0.43	-0.43	NUM
admet-373	559	87	9.00	9.00	NUM
admet-373	559	88	0.95	0.95	NUM
admet-373	559	89	carbamazepine	carbamazepine	NOUN
admet-373	559	90	train	train	NOUN
admet-373	559	91	.	.	PUNCT
admet-373	560	1	800	800	NUM
admet-373	560	2	4.6	4.6	NUM
admet-373	560	3	1	1	NUM
admet-373	560	4	17.00	17.00	NUM
admet-373	560	5	1.23	1.23	NUM
admet-373	560	6	celecoxib	celecoxib	NOUN
admet-373	560	7	test	test	NOUN
admet-373	560	8	400	400	NUM
admet-373	560	9	8.5	8.5	NUM
admet-373	560	10	2	2	NUM
admet-373	560	11	6.13	6.13	NUM
admet-373	560	12	0.79	0.79	NUM
admet-373	560	13	204.33	204.33	NUM
admet-373	560	14	2.31	2.31	NUM
admet-373	560	15	6.59	6.59	NUM
admet-373	560	16	0.82	0.82	NUM
admet-373	560	17	11.00	11.00	NUM
admet-373	560	18	1.04	1.04	NUM
admet-373	560	19	cilostazol	cilostazol	ADJ
admet-373	560	20	test	test	NOUN
admet-373	560	21	200	200	NUM
admet-373	560	22	6.7	6.7	NUM
admet-373	560	23	2	2	NUM
admet-373	560	24	12.00	12.00	NUM
admet-373	560	25	1.08	1.08	NUM
admet-373	560	26	citalopram	citalopram	PROPN
admet-373	560	27	hydrobromide	hydrobromide	PROPN
admet-373	560	28	test	test	NOUN
admet-373	560	29	20	20	NUM
admet-373	560	30	8.3	8.3	NUM
admet-373	560	31	1	1	NUM
admet-373	560	32	12	12	NUM
admet-373	560	33	1.08	1.08	NUM
admet-373	560	34	60.00	60.00	NUM
admet-373	560	35	1.78	1.78	NUM
admet-373	560	36	4.30	4.30	NUM
admet-373	560	37	0.63	0.63	NUM
admet-373	560	38	33.00	33.00	NUM
admet-373	560	39	1.52	1.52	NUM
admet-373	560	40	clomipramine	clomipramine	NOUN
admet-373	560	41	hydrochloride	hydrochloride	NOUN
admet-373	560	42	test	test	NOUN
admet-373	560	43	25	25	NUM
admet-373	560	44	7.9	7.9	NUM
admet-373	560	45	1	1	NUM
admet-373	560	46	13	13	NUM
admet-373	560	47	1.11	1.11	NUM
admet-373	560	48	433.33	433.33	NUM
admet-373	560	49	2.64	2.64	NUM
admet-373	560	50	8.20	8.20	NUM
admet-373	560	51	0.91	0.91	NUM
admet-373	560	52	26.00	26.00	NUM
admet-373	560	53	1.41	1.41	NUM
admet-373	560	54	clonidine	clonidine	NOUN
admet-373	560	55	hydrochloride	hydrochloride	NOUN
admet-373	560	56	train	train	NOUN
admet-373	560	57	.	.	PUNCT
admet-373	561	1	0	0	NUM
admet-373	562	1	8.5	8.5	NUM
admet-373	562	2	1	1	NUM
admet-373	562	3	3.3	3.3	NUM
admet-373	562	4	0.52	0.52	NUM
admet-373	562	5	5.89	5.89	NUM
admet-373	562	6	0.77	0.77	NUM
admet-373	562	7	4.00	4.00	NUM
admet-373	562	8	0.60	0.60	NUM
admet-373	562	9	7.60	7.60	NUM
admet-373	562	10	0.88	0.88	NUM
admet-373	562	11	dapsone	dapsone	NOUN
admet-373	562	12	test	test	NOUN
admet-373	562	13	100	100	NUM
admet-373	562	14	4.8	4.8	NUM
admet-373	562	15	1	1	NUM
admet-373	562	16	0.83	0.83	NUM
admet-373	562	17	-0.08	-0.08	NUM
admet-373	562	18	3.32	3.32	NUM
admet-373	562	19	0.52	0.52	NUM
admet-373	562	20	0.48	0.48	NUM
admet-373	562	21	-0.32	-0.32	NUM
admet-373	562	22	22.00	22.00	NUM
admet-373	562	23	1.34	1.34	NUM
admet-373	562	24	desloratadine	desloratadine	NOUN
admet-373	562	25	test	test	NOUN
admet-373	562	26	5	5	NUM
admet-373	562	27	9.4	9.4	NUM
admet-373	562	28	1	1	NUM
admet-373	562	29	50.00	50.00	NUM
admet-373	562	30	1.70	1.70	NUM
admet-373	562	31	valko	valko	NOUN
admet-373	562	32	,	,	PUNCT
admet-373	562	33	teague	teague	NOUN
admet-373	562	34	and	and	CCONJ
admet-373	562	35	pidgeon	pidgeon	PROPN
admet-373	562	36	admet	admet	PROPN
admet-373	562	37	&	&	CCONJ
admet-373	562	38	dmpk	dmpk	PROPN
admet-373	562	39	5(1	5(1	NUM
admet-373	562	40	)	)	PUNCT
admet-373	562	41	(	(	PUNCT
admet-373	562	42	2017	2017	NUM
admet-373	562	43	)	)	PUNCT
admet-373	562	44	14	14	NUM
admet-373	562	45	-	-	SYM
admet-373	562	46	38	38	NUM
admet-373	562	47	32	32	NUM
admet-373	562	48	diazoxide	diazoxide	NOUN
admet-373	562	49	train	train	NOUN
admet-373	562	50	.	.	PUNCT
admet-373	563	1	150	150	NUM
admet-373	563	2	4.7	4.7	NUM
admet-373	563	3	3	3	NUM
admet-373	563	4	0.21	0.21	NUM
admet-373	563	5	-0.68	-0.68	NOUN
admet-373	563	6	3.50	3.50	NUM
admet-373	563	7	0.54	0.54	NUM
admet-373	563	8	0.06	0.06	NUM
admet-373	563	9	-1.22	-1.22	ADP
admet-373	563	10	48.00	48.00	NUM
admet-373	563	11	1.68	1.68	NUM
admet-373	563	12	didanosine	didanosine	NOUN
admet-373	563	13	test	test	NOUN
admet-373	563	14	250	250	NUM
admet-373	563	15	8	8	NUM
admet-373	563	16	2	2	NUM
admet-373	563	17	0.77	0.77	NUM
admet-373	563	18	-0.11	-0.11	NUM
admet-373	563	19	0.81	0.81	NUM
admet-373	563	20	-0.09	-0.09	NUM
admet-373	563	21	11.00	11.00	NUM
admet-373	563	22	1.04	1.04	NUM
admet-373	563	23	1.40	1.40	NUM
admet-373	563	24	0.15	0.15	NUM
admet-373	563	25	diflunisal	diflunisal	NOUN
admet-373	563	26	train	train	NOUN
admet-373	563	27	.	.	PUNCT
admet-373	564	1	1000	1000	NUM
admet-373	564	2	4.2	4.2	NUM
admet-373	564	3	2	2	NUM
admet-373	564	4	0.1	0.1	NUM
admet-373	564	5	-1.00	-1.00	NUM
admet-373	564	6	0.10	0.10	NUM
admet-373	564	7	-1.00	-1.00	NUM
admet-373	564	8	10.00	10.00	NUM
admet-373	564	9	1.00	1.00	NUM
admet-373	564	10	diphenhydramine	diphenhydramine	NOUN
admet-373	564	11	hydrochloride	hydrochloride	NOUN
admet-373	564	12	train	train	NOUN
admet-373	564	13	.	.	PUNCT
admet-373	565	1	75	75	NUM
admet-373	565	2	8.1	8.1	NUM
admet-373	565	3	3	3	NUM
admet-373	565	4	6.5	6.5	NUM
admet-373	565	5	0.81	0.81	NUM
admet-373	565	6	34.21	34.21	NUM
admet-373	565	7	1.53	1.53	NUM
admet-373	565	8	9.80	9.80	NUM
admet-373	565	9	0.99	0.99	NUM
admet-373	565	10	9.30	9.30	NUM
admet-373	565	11	0.97	0.97	NUM
admet-373	565	12	dipyridamole	dipyridamole	NOUN
admet-373	565	13	train	train	NOUN
admet-373	565	14	.	.	PUNCT
admet-373	566	1	200	200	NUM
admet-373	566	2	6.7	6.7	NUM
admet-373	566	3	2	2	NUM
admet-373	566	4	1.75	1.75	NUM
admet-373	566	5	0.24	0.24	NUM
admet-373	566	6	175.00	175.00	NUM
admet-373	566	7	2.24	2.24	NUM
admet-373	566	8	3.00	3.00	NUM
admet-373	566	9	0.48	0.48	NUM
admet-373	566	10	0.70	0.70	NUM
admet-373	566	11	-0.15	-0.15	NOUN
admet-373	566	12	domperidone	domperidone	NOUN
admet-373	566	13	test	test	NOUN
admet-373	566	14	30	30	NUM
admet-373	566	15	9.8	9.8	NUM
admet-373	566	16	3	3	NUM
admet-373	566	17	3.4	3.4	NUM
admet-373	566	18	0.53	0.53	NUM
admet-373	566	19	42.50	42.50	NUM
admet-373	566	20	1.63	1.63	NUM
admet-373	566	21	9.50	9.50	NUM
admet-373	566	22	0.98	0.98	NUM
admet-373	566	23	7.50	7.50	NUM
admet-373	566	24	0.88	0.88	NUM
admet-373	566	25	donepezil	donepezil	NOUN
admet-373	566	26	hydrochloride	hydrochloride	NOUN
admet-373	566	27	test	test	NOUN
admet-373	566	28	5	5	NUM
admet-373	566	29	8.2	8.2	NUM
admet-373	566	30	1	1	NUM
admet-373	566	31	12	12	NUM
admet-373	566	32	1.08	1.08	NUM
admet-373	566	33	300.00	300.00	NUM
admet-373	566	34	2.48	2.48	NUM
admet-373	566	35	2.17	2.17	NUM
admet-373	566	36	0.34	0.34	NUM
admet-373	566	37	70.00	70.00	NUM
admet-373	566	38	1.85	1.85	NUM
admet-373	566	39	efavirenz	efavirenz	NOUN
admet-373	566	40	test	test	NOUN
admet-373	566	41	600	600	NUM
admet-373	566	42	8.9	8.9	NUM
admet-373	566	43	1	1	NUM
admet-373	566	44	47.00	47.00	NUM
admet-373	566	45	1.67	1.67	NUM
admet-373	566	46	etodolac	etodolac	PROPN
admet-373	566	47	test	test	NOUN
admet-373	566	48	600	600	NUM
admet-373	566	49	6.2	6.2	NUM
admet-373	566	50	2	2	NUM
admet-373	566	51	0.39	0.39	NUM
admet-373	566	52	-0.41	-0.41	ADP
admet-373	566	53	39.00	39.00	NUM
admet-373	566	54	1.59	1.59	NUM
admet-373	566	55	0.82	0.82	NUM
admet-373	566	56	-0.09	-0.09	NUM
admet-373	566	57	7.30	7.30	NUM
admet-373	566	58	0.86	0.86	NUM
admet-373	566	59	felbamate	felbamate	NOUN
admet-373	566	60	train	train	NOUN
admet-373	566	61	.	.	PUNCT
admet-373	567	1	1200	1200	NUM
admet-373	567	2	3.4	3.4	NUM
admet-373	567	3	3	3	NUM
admet-373	567	4	0.76	0.76	NUM
admet-373	567	5	-0.12	-0.12	NUM
admet-373	567	6	1.09	1.09	NUM
admet-373	567	7	0.04	0.04	NUM
admet-373	567	8	0.50	0.50	NUM
admet-373	567	9	-0.30	-0.30	VERB
admet-373	567	10	22.00	22.00	NUM
admet-373	567	11	1.34	1.34	NUM
admet-373	567	12	felodipine	felodipine	NOUN
admet-373	567	13	train	train	NOUN
admet-373	567	14	.	.	PUNCT
admet-373	568	1	5	5	NUM
admet-373	568	2	9.8	9.8	NUM
admet-373	568	3	1	1	NUM
admet-373	568	4	4.4	4.4	NUM
admet-373	568	5	0.64	0.64	NUM
admet-373	568	6	11.00	11.00	NUM
admet-373	568	7	1.04	1.04	NUM
admet-373	568	8	10.00	10.00	NUM
admet-373	568	9	1.00	1.00	NUM
admet-373	568	10	fexofenadine	fexofenadine	NOUN
admet-373	568	11	hydrochloride	hydrochloride	NOUN
admet-373	568	12	test	test	NOUN
admet-373	568	13	60	60	NUM
admet-373	568	14	7.3	7.3	NUM
admet-373	568	15	2	2	NUM
admet-373	568	16	14.40	14.40	NUM
admet-373	568	17	1.16	1.16	NUM
admet-373	568	18	finasteride	finasteride	ADJ
admet-373	568	19	train	train	NOUN
admet-373	568	20	.	.	PUNCT
admet-373	569	1	5	5	NUM
admet-373	569	2	7.3	7.3	NUM
admet-373	569	3	1	1	NUM
admet-373	569	4	0.89	0.89	NUM
admet-373	569	5	-0.05	-0.05	NUM
admet-373	569	6	5.56	5.56	NUM
admet-373	569	7	0.75	0.75	NUM
admet-373	569	8	4.70	4.70	NUM
admet-373	569	9	0.67	0.67	NUM
admet-373	569	10	3.00	3.00	NUM
admet-373	569	11	0.48	0.48	NUM
admet-373	569	12	fluoxetine	fluoxetine	NOUN
admet-373	569	13	hydrochloride	hydrochloride	NOUN
admet-373	569	14	train	train	NOUN
admet-373	569	15	.	.	PUNCT
admet-373	570	1	60	60	NUM
admet-373	570	2	8.6	8.6	NUM
admet-373	570	3	1	1	NUM
admet-373	570	4	32.5	32.5	NUM
admet-373	570	5	1.51	1.51	NUM
admet-373	570	6	541.67	541.67	NUM
admet-373	570	7	2.73	2.73	NUM
admet-373	570	8	48.00	48.00	NUM
admet-373	570	9	1.68	1.68	NUM
admet-373	570	10	flurbiprofen	flurbiprofen	NOUN
admet-373	570	11	train	train	NOUN
admet-373	570	12	.	.	PUNCT
admet-373	571	1	200	200	NUM
admet-373	571	2	6.2	6.2	NUM
admet-373	571	3	4	4	NUM
admet-373	571	4	0.12	0.12	NUM
admet-373	571	5	-0.92	-0.92	ADP
admet-373	571	6	5.00	5.00	NUM
admet-373	571	7	0.70	0.70	NUM
admet-373	571	8	flutamide	flutamide	NOUN
admet-373	571	9	test	test	NOUN
admet-373	571	10	750	750	NUM
admet-373	571	11	5.9	5.9	NUM
admet-373	571	12	3	3	NUM
admet-373	571	13	6.00	6.00	NUM
admet-373	571	14	0.78	0.78	NUM
admet-373	571	15	fluvoxamine	fluvoxamine	PROPN
admet-373	571	16	maleate	maleate	PROPN
admet-373	571	17	test	test	NOUN
admet-373	571	18	50	50	NUM
admet-373	571	19	8.3	8.3	NUM
admet-373	571	20	1	1	NUM
admet-373	571	21	25	25	NUM
admet-373	571	22	1.40	1.40	NUM
admet-373	571	23	125.00	125.00	NUM
admet-373	571	24	2.10	2.10	NUM
admet-373	571	25	15.60	15.60	NUM
admet-373	571	26	1.19	1.19	NUM
admet-373	571	27	furosemide	furosemide	ADJ
admet-373	571	28	train	train	NOUN
admet-373	571	29	.	.	PUNCT
admet-373	572	1	80	80	NUM
admet-373	572	2	5	5	NUM
admet-373	572	3	2	2	NUM
admet-373	572	4	0.12	0.12	NUM
admet-373	572	5	-0.92	-0.92	ADP
admet-373	572	6	12.00	12.00	NUM
admet-373	572	7	1.08	1.08	NUM
admet-373	572	8	1.60	1.60	NUM
admet-373	572	9	0.20	0.20	NUM
admet-373	572	10	2.50	2.50	NUM
admet-373	572	11	0.40	0.40	NUM
admet-373	572	12	glibenclamide	glibenclamide	NOUN
admet-373	572	13	test	test	NOUN
admet-373	572	14	3	3	NUM
admet-373	572	15	5.3	5.3	NUM
admet-373	572	16	1	1	NUM
admet-373	572	17	0.13	0.13	NUM
admet-373	572	18	-0.89	-0.89	NUM
admet-373	572	19	13.00	13.00	NUM
admet-373	572	20	1.11	1.11	NUM
admet-373	572	21	1.30	1.30	NUM
admet-373	572	22	0.11	0.11	NUM
admet-373	572	23	1.60	1.60	NUM
admet-373	572	24	0.20	0.20	NUM
admet-373	572	25	glimepiride	glimepiride	NOUN
admet-373	572	26	test	test	NOUN
admet-373	572	27	1	1	NUM
admet-373	572	28	5.4	5.4	NUM
admet-373	572	29	1	1	NUM
admet-373	572	30	0.19	0.19	NUM
admet-373	572	31	-0.72	-0.72	NUM
admet-373	572	32	19.00	19.00	NUM
admet-373	572	33	1.28	1.28	NUM
admet-373	572	34	0.50	0.50	NUM
admet-373	572	35	-0.30	-0.30	VERB
admet-373	572	36	10.00	10.00	NUM
admet-373	572	37	1.00	1.00	NUM
admet-373	572	38	glipizide	glipizide	NOUN
admet-373	572	39	train	train	NOUN
admet-373	572	40	.	.	PUNCT
admet-373	573	1	3	3	NUM
admet-373	573	2	5.5	5.5	NUM
admet-373	573	3	1	1	NUM
admet-373	573	4	0.16	0.16	NUM
admet-373	573	5	-0.80	-0.80	VERB
admet-373	573	6	8.00	8.00	NUM
admet-373	573	7	0.90	0.90	NUM
admet-373	573	8	0.56	0.56	NUM
admet-373	573	9	-0.25	-0.25	NUM
admet-373	573	10	3.30	3.30	NUM
admet-373	573	11	0.52	0.52	NUM
admet-373	573	12	granisetron	granisetron	ADJ
admet-373	573	13	hydrochloride	hydrochloride	NOUN
admet-373	573	14	test	test	NOUN
admet-373	573	15	2	2	NUM
admet-373	573	16	9.9	9.9	NUM
admet-373	573	17	2	2	NUM
admet-373	573	18	3.7	3.7	NUM
admet-373	573	19	0.57	0.57	NUM
admet-373	573	20	10.57	10.57	NUM
admet-373	573	21	1.02	1.02	NUM
admet-373	573	22	9.10	9.10	NUM
admet-373	573	23	0.96	0.96	NUM
admet-373	573	24	5.20	5.20	NUM
admet-373	573	25	0.72	0.72	NUM
admet-373	573	26	guanabenz	guanabenz	PROPN
admet-373	573	27	acetate	acetate	PROPN
admet-373	573	28	test	test	NOUN
admet-373	573	29	8	8	NUM
admet-373	573	30	8.2	8.2	NUM
admet-373	573	31	2	2	NUM
admet-373	573	32	6.00	6.00	NUM
admet-373	573	33	0.78	0.78	NUM
admet-373	573	34	haloperidol	haloperidol	ADJ
admet-373	573	35	test	test	NOUN
admet-373	573	36	2	2	NUM
admet-373	573	37	10	10	NUM
admet-373	573	38	2	2	NUM
admet-373	573	39	17	17	NUM
admet-373	573	40	1.23	1.23	NUM
admet-373	573	41	212.50	212.50	NUM
admet-373	573	42	2.33	2.33	NUM
admet-373	573	43	7.80	7.80	NUM
admet-373	573	44	0.89	0.89	NUM
admet-373	573	45	35.00	35.00	NUM
admet-373	573	46	1.54	1.54	NUM
admet-373	573	47	hydrochlorothia	hydrochlorothia	NOUN
admet-373	573	48	zide	zide	PROPN
admet-373	573	49	test	test	NOUN
admet-373	573	50	50	50	NUM
admet-373	573	51	4.7	4.7	NUM
admet-373	573	52	2	2	NUM
admet-373	573	53	8.00	8.00	NUM
admet-373	573	54	0.90	0.90	NUM
admet-373	573	55	imipramine	imipramine	ADJ
admet-373	573	56	hydrochloride	hydrochloride	NOUN
admet-373	573	57	train	train	NOUN
admet-373	573	58	.	.	PUNCT
admet-373	574	1	75	75	NUM
admet-373	574	2	6.6	6.6	NUM
admet-373	574	3	1	1	NUM
admet-373	574	4	12	12	NUM
admet-373	574	5	1.08	1.08	NUM
admet-373	574	6	150.00	150.00	NUM
admet-373	574	7	2.18	2.18	NUM
admet-373	574	8	13.00	13.00	NUM
admet-373	574	9	1.11	1.11	NUM
admet-373	574	10	16.00	16.00	NUM
admet-373	574	11	1.20	1.20	NUM
admet-373	574	12	indapamide	indapamide	NOUN
admet-373	574	13	test	test	NOUN
admet-373	574	14	1	1	NUM
admet-373	574	15	4.2	4.2	NUM
admet-373	574	16	1	1	NUM
admet-373	574	17	14.00	14.00	NUM
admet-373	574	18	1.15	1.15	NUM
admet-373	574	19	indomethacin	indomethacin	NOUN
admet-373	574	20	train	train	NOUN
admet-373	574	21	.	.	PUNCT
admet-373	575	1	75	75	NUM
admet-373	575	2	6.5	6.5	NUM
admet-373	575	3	3	3	NUM
admet-373	575	4	0.1	0.1	NUM
admet-373	575	5	-1.00	-1.00	NUM
admet-373	575	6	10.00	10.00	NUM
admet-373	575	7	1.00	1.00	NUM
admet-373	575	8	1.30	1.30	NUM
admet-373	575	9	0.11	0.11	NUM
admet-373	575	10	1.40	1.40	NUM
admet-373	575	11	0.15	0.15	NUM
admet-373	575	12	irbesartan	irbesartan	ADJ
admet-373	575	13	test	test	NOUN
admet-373	575	14	150	150	NUM
admet-373	575	15	9.3	9.3	NUM
admet-373	575	16	1	1	NUM
admet-373	575	17	0.94	0.94	NUM
admet-373	575	18	-0.03	-0.03	NUM
admet-373	575	19	9.40	9.40	NUM
admet-373	575	20	0.97	0.97	NUM
admet-373	575	21	2.30	2.30	NUM
admet-373	575	22	0.36	0.36	NUM
admet-373	575	23	14.00	14.00	NUM
admet-373	575	24	1.15	1.15	NUM
admet-373	575	25	isradipine	isradipine	PROPN
admet-373	575	26	test	test	NOUN
admet-373	575	27	5	5	NUM
admet-373	575	28	6.6	6.6	NUM
admet-373	575	29	2	2	NUM
admet-373	575	30	1.5	1.5	NUM
admet-373	575	31	0.18	0.18	NUM
admet-373	575	32	37.50	37.50	NUM
admet-373	575	33	1.57	1.57	NUM
admet-373	575	34	26.00	26.00	NUM
admet-373	575	35	1.41	1.41	NUM
admet-373	575	36	3.30	3.30	NUM
admet-373	575	37	0.52	0.52	NUM
admet-373	575	38	ketoconazole	ketoconazole	NOUN
admet-373	575	39	train	train	NOUN
admet-373	575	40	.	.	PUNCT
admet-373	576	1	200	200	NUM
admet-373	576	2	4.7	4.7	NUM
admet-373	576	3	1	1	NUM
admet-373	576	4	2.00	2.00	NUM
admet-373	576	5	0.30	0.30	NUM
admet-373	576	6	ketoprofen	ketoprofen	NOUN
admet-373	576	7	train	train	NOUN
admet-373	576	8	.	.	PUNCT
admet-373	577	1	225	225	NUM
admet-373	577	2	7.6	7.6	NUM
admet-373	577	3	3	3	NUM
admet-373	577	4	0.13	0.13	NUM
admet-373	577	5	-0.89	-0.89	NUM
admet-373	577	6	1.63	1.63	NUM
admet-373	577	7	0.21	0.21	NUM
admet-373	577	8	1.60	1.60	NUM
admet-373	577	9	0.20	0.20	NUM
admet-373	577	10	2.10	2.10	NUM
admet-373	577	11	0.32	0.32	NUM
admet-373	577	12	lamotrigine	lamotrigine	PROPN
admet-373	577	13	test	test	NOUN
admet-373	577	14	25	25	NUM
admet-373	577	15	4	4	NUM
admet-373	577	16	1	1	NUM
admet-373	577	17	1.1	1.1	NUM
admet-373	577	18	0.04	0.04	NUM
admet-373	577	19	2.44	2.44	NUM
admet-373	577	20	0.39	0.39	NUM
admet-373	577	21	0.58	0.58	NUM
admet-373	577	22	-0.24	-0.24	NUM
admet-373	577	23	25.00	25.00	NUM
admet-373	577	24	1.40	1.40	NUM
admet-373	577	25	lansoprazole	lansoprazole	NOUN
admet-373	577	26	test	test	NOUN
admet-373	577	27	15	15	NUM
admet-373	577	28	7.1	7.1	NUM
admet-373	577	29	1	1	NUM
admet-373	577	30	0.28	0.28	NUM
admet-373	577	31	-0.55	-0.55	NUM
admet-373	577	32	14.00	14.00	NUM
admet-373	577	33	1.15	1.15	NUM
admet-373	577	34	4.40	4.40	NUM
admet-373	577	35	0.64	0.64	NUM
admet-373	577	36	1.00	1.00	NUM
admet-373	577	37	0.00	0.00	NUM
admet-373	577	38	leflunomide	leflunomide	ADJ
admet-373	577	39	test	test	NOUN
admet-373	577	40	100	100	NUM
admet-373	577	41	4.9	4.9	NUM
admet-373	577	42	1	1	NUM
admet-373	577	43	0.13	0.13	NUM
admet-373	577	44	-0.89	-0.89	NUM
admet-373	577	45	13.00	13.00	NUM
admet-373	577	46	1.11	1.11	NUM
admet-373	577	47	336.00	336.00	NUM
admet-373	577	48	2.53	2.53	NUM
admet-373	577	49	admet	admet	NOUN
admet-373	577	50	&	&	CCONJ
admet-373	577	51	dmpk	dmpk	PROPN
admet-373	577	52	5(1	5(1	NUM
admet-373	577	53	)	)	PUNCT
admet-373	577	54	(	(	PUNCT
admet-373	577	55	2017	2017	NUM
admet-373	577	56	)	)	PUNCT
admet-373	577	57	14	14	NUM
admet-373	577	58	-	-	SYM
admet-373	577	59	38	38	NUM
admet-373	577	60	in	in	ADP
admet-373	577	61	vitro	vitro	X
admet-373	577	62	membrane	membrane	NOUN
admet-373	577	63	and	and	CCONJ
admet-373	577	64	protein	protein	NOUN
admet-373	577	65	binding	bind	VERB
admet-373	577	66	doi	doi	NOUN
admet-373	577	67	:	:	PUNCT
admet-373	577	68	10.5599	10.5599	NUM
admet-373	577	69	/	/	SYM
admet-373	577	70	admet.5.1.373	admet.5.1.373	ADP
admet-373	577	71	33	33	NUM
admet-373	577	72	letrozole	letrozole	NOUN
admet-373	577	73	test	test	NOUN
admet-373	578	1	3	3	NUM
admet-373	578	2	7.9	7.9	NUM
admet-373	578	3	1	1	NUM
admet-373	578	4	1.9	1.9	NUM
admet-373	578	5	0.28	0.28	NUM
admet-373	578	6	4.63	4.63	NUM
admet-373	578	7	0.67	0.67	NUM
admet-373	578	8	0.57	0.57	NUM
admet-373	578	9	-0.24	-0.24	NUM
admet-373	578	10	45.00	45.00	NUM
admet-373	578	11	1.65	1.65	NUM
admet-373	578	12	lorazepam	lorazepam	NOUN
admet-373	578	13	train	train	NOUN
admet-373	578	14	.	.	PUNCT
admet-373	579	1	3	3	NUM
admet-373	579	2	8.9	8.9	NUM
admet-373	579	3	3	3	NUM
admet-373	579	4	1.3	1.3	NUM
admet-373	579	5	0.11	0.11	NUM
admet-373	579	6	14.44	14.44	NUM
admet-373	579	7	1.16	1.16	NUM
admet-373	579	8	1.00	1.00	NUM
admet-373	579	9	0.00	0.00	NUM
admet-373	579	10	17.00	17.00	NUM
admet-373	579	11	1.23	1.23	NUM
admet-373	579	12	lovastatin	lovastatin	PROPN
admet-373	579	13	test	test	NOUN
admet-373	579	14	10	10	NUM
admet-373	579	15	9.5	9.5	NUM
admet-373	579	16	1	1	NUM
admet-373	579	17	0.87	0.87	NUM
admet-373	579	18	-0.06	-0.06	NUM
admet-373	579	19	21.75	21.75	NUM
admet-373	579	20	1.34	1.34	NUM
admet-373	579	21	7.20	7.20	NUM
admet-373	579	22	0.86	0.86	NUM
admet-373	579	23	1.40	1.40	NUM
admet-373	579	24	0.15	0.15	NUM
admet-373	579	25	loxapine	loxapine	NOUN
admet-373	579	26	succinate	succinate	NOUN
admet-373	579	27	test	test	NOUN
admet-373	579	28	40	40	NUM
admet-373	579	29	8.3	8.3	NUM
admet-373	579	30	2	2	NUM
admet-373	579	31	4.00	4.00	NUM
admet-373	579	32	0.60	0.60	NUM
admet-373	579	33	maprotiline	maprotiline	ADJ
admet-373	579	34	hydrochloride	hydrochloride	NOUN
admet-373	579	35	train	train	NOUN
admet-373	579	36	.	.	PUNCT
admet-373	580	1	75	75	NUM
admet-373	580	2	4.4	4.4	NUM
admet-373	580	3	3	3	NUM
admet-373	580	4	45	45	NUM
admet-373	580	5	1.65	1.65	NUM
admet-373	580	6	409.09	409.09	NUM
admet-373	580	7	2.61	2.61	NUM
admet-373	580	8	14.00	14.00	NUM
admet-373	580	9	1.15	1.15	NUM
admet-373	580	10	51.00	51.00	NUM
admet-373	580	11	1.71	1.71	NUM
admet-373	580	12	mebendazole	mebendazole	NOUN
admet-373	580	13	train	train	NOUN
admet-373	580	14	.	.	PUNCT
admet-373	581	1	200	200	NUM
admet-373	581	2	6.7	6.7	NUM
admet-373	581	3	2	2	NUM
admet-373	581	4	1.2	1.2	NUM
admet-373	581	5	0.08	0.08	NUM
admet-373	581	6	13.33	13.33	NUM
admet-373	581	7	1.12	1.12	NUM
admet-373	581	8	15.00	15.00	NUM
admet-373	581	9	1.18	1.18	NUM
admet-373	581	10	1.10	1.10	NUM
admet-373	581	11	0.04	0.04	NUM
admet-373	581	12	mercaptopurine	mercaptopurine	NOUN
admet-373	581	13	test	test	NOUN
admet-373	581	14	3	3	NUM
admet-373	581	15	4.8	4.8	NUM
admet-373	581	16	1	1	NUM
admet-373	581	17	1	1	NUM
admet-373	581	18	0.00	0.00	NUM
admet-373	581	19	1.18	1.18	NUM
admet-373	581	20	0.07	0.07	NUM
admet-373	581	21	15.00	15.00	NUM
admet-373	581	22	1.18	1.18	NUM
admet-373	581	23	1.00	1.00	NUM
admet-373	581	24	0.00	0.00	NUM
admet-373	581	25	methylprednisolone	methylprednisolone	ADJ
admet-373	581	26	train	train	NOUN
admet-373	581	27	.	.	PUNCT
admet-373	582	1	4	4	NUM
admet-373	582	2	6.3	6.3	NUM
admet-373	582	3	1	1	NUM
admet-373	582	4	1.2	1.2	NUM
admet-373	582	5	0.08	0.08	NUM
admet-373	582	6	5.22	5.22	NUM
admet-373	582	7	0.72	0.72	NUM
admet-373	582	8	6.10	6.10	NUM
admet-373	582	9	0.79	0.79	NUM
admet-373	582	10	2.30	2.30	NUM
admet-373	582	11	0.36	0.36	NUM
admet-373	582	12	metoclopramide	metoclopramide	NOUN
admet-373	582	13	hydrochloride	hydrochloride	NOUN
admet-373	582	14	test	test	NOUN
admet-373	582	15	20	20	NUM
admet-373	582	16	8.4	8.4	NUM
admet-373	582	17	2	2	NUM
admet-373	582	18	3.2	3.2	NUM
admet-373	582	19	0.51	0.51	NUM
admet-373	582	20	5.33	5.33	NUM
admet-373	582	21	0.73	0.73	NUM
admet-373	582	22	5.70	5.70	NUM
admet-373	582	23	0.76	0.76	NUM
admet-373	582	24	7.20	7.20	NUM
admet-373	582	25	0.86	0.86	NUM
admet-373	582	26	metolazone	metolazone	NOUN
admet-373	582	27	test	test	NOUN
admet-373	582	28	3	3	NUM
admet-373	582	29	5.7	5.7	NUM
admet-373	582	30	1	1	NUM
admet-373	582	31	14.00	14.00	NUM
admet-373	582	32	1.15	1.15	NUM
admet-373	582	33	mianserin	mianserin	NOUN
admet-373	582	34	train	train	NOUN
admet-373	582	35	.	.	PUNCT
admet-373	583	1	60	60	NUM
admet-373	583	2	8.1	8.1	NUM
admet-373	583	3	2	2	NUM
admet-373	583	4	13.50	13.50	NUM
admet-373	583	5	1.13	1.13	NUM
admet-373	583	6	mibefradil	mibefradil	NOUN
admet-373	583	7	dihydrochloride	dihydrochloride	NOUN
admet-373	583	8	test	test	VERB
admet-373	583	9	50	50	NUM
admet-373	583	10	6.2	6.2	NUM
admet-373	583	11	1	1	NUM
admet-373	583	12	3.1	3.1	NUM
admet-373	583	13	0.49	0.49	NUM
admet-373	583	14	310.00	310.00	NUM
admet-373	583	15	2.49	2.49	NUM
admet-373	583	16	4.00	4.00	NUM
admet-373	583	17	0.60	0.60	NUM
admet-373	583	18	13.00	13.00	NUM
admet-373	583	19	1.11	1.11	NUM
admet-373	583	20	mifepristone	mifepristone	NOUN
admet-373	583	21	test	test	NOUN
admet-373	583	22	600	600	NUM
admet-373	583	23	8	8	NUM
admet-373	583	24	1	1	NUM
admet-373	583	25	18.00	18.00	NUM
admet-373	583	26	1.26	1.26	NUM
admet-373	583	27	mycophenolic	mycophenolic	ADJ
admet-373	583	28	acid	acid	NOUN
admet-373	583	29	test	test	NOUN
admet-373	583	30	1440	1440	NUM
admet-373	583	31	8	8	NUM
admet-373	583	32	2	2	NUM
admet-373	583	33	0.77	0.77	NUM
admet-373	583	34	-0.11	-0.11	NUM
admet-373	583	35	38.50	38.50	NUM
admet-373	583	36	1.59	1.59	NUM
admet-373	583	37	2.00	2.00	NUM
admet-373	583	38	0.30	0.30	NUM
admet-373	583	39	12.00	12.00	NUM
admet-373	583	40	1.08	1.08	NUM
admet-373	583	41	nadolol	nadolol	NOUN
admet-373	583	42	train	train	NOUN
admet-373	583	43	.	.	PUNCT
admet-373	584	1	40	40	NUM
admet-373	584	2	8.9	8.9	NUM
admet-373	584	3	1	1	NUM
admet-373	584	4	1.9	1.9	NUM
admet-373	584	5	0.28	0.28	NUM
admet-373	584	6	13.57	13.57	NUM
admet-373	584	7	1.13	1.13	NUM
admet-373	584	8	2.90	2.90	NUM
admet-373	584	9	0.46	0.46	NUM
admet-373	584	10	9.20	9.20	NUM
admet-373	584	11	0.96	0.96	NUM
admet-373	584	12	naproxen	naproxen	NOUN
admet-373	584	13	train	train	NOUN
admet-373	584	14	.	.	PUNCT
admet-373	585	1	1000	1000	NUM
admet-373	585	2	5.2	5.2	NUM
admet-373	585	3	2	2	NUM
admet-373	585	4	15.00	15.00	NUM
admet-373	585	5	1.18	1.18	NUM
admet-373	585	6	neostigmine	neostigmine	NOUN
admet-373	585	7	bromide	bromide	NOUN
admet-373	585	8	train	train	NOUN
admet-373	585	9	.	.	PUNCT
admet-373	586	1	15	15	NUM
admet-373	586	2	7.4	7.4	NUM
admet-373	586	3	1	1	NUM
admet-373	586	4	0.74	0.74	NUM
admet-373	586	5	-0.13	-0.13	NUM
admet-373	586	6	9.20	9.20	NUM
admet-373	586	7	0.96	0.96	NUM
admet-373	586	8	1.30	1.30	NUM
admet-373	586	9	0.11	0.11	NUM
admet-373	586	10	nevirapine	nevirapine	ADJ
admet-373	586	11	test	test	NOUN
admet-373	586	12	200	200	NUM
admet-373	586	13	8	8	NUM
admet-373	586	14	1	1	NUM
admet-373	586	15	1.3	1.3	NUM
admet-373	586	16	0.11	0.11	NUM
admet-373	586	17	4.06	4.06	NUM
admet-373	586	18	0.61	0.61	NUM
admet-373	586	19	0.30	0.30	NUM
admet-373	586	20	-0.52	-0.52	NUM
admet-373	586	21	53.00	53.00	NUM
admet-373	586	22	1.72	1.72	NUM
admet-373	586	23	nicardipine	nicardipine	NOUN
admet-373	586	24	hydrochloride	hydrochloride	NOUN
admet-373	586	25	train	train	NOUN
admet-373	586	26	.	.	PUNCT
admet-373	587	1	60	60	NUM
admet-373	587	2	5.6	5.6	NUM
admet-373	587	3	2	2	NUM
admet-373	587	4	1	1	NUM
admet-373	587	5	0.00	0.00	NUM
admet-373	587	6	100.00	100.00	NUM
admet-373	587	7	2.00	2.00	NUM
admet-373	587	8	11.00	11.00	NUM
admet-373	587	9	1.04	1.04	NUM
admet-373	587	10	4.10	4.10	NUM
admet-373	587	11	0.61	0.61	NUM
admet-373	587	12	nimesulide	nimesulide	ADP
admet-373	587	13	test	test	NOUN
admet-373	587	14	400	400	NUM
admet-373	587	15	4.4	4.4	NUM
admet-373	587	16	2	2	NUM
admet-373	587	17	2.80	2.80	NUM
admet-373	587	18	0.45	0.45	NUM
admet-373	587	19	nimodipine	nimodipine	ADJ
admet-373	587	20	test	test	NOUN
admet-373	587	21	120	120	NUM
admet-373	587	22	9.6	9.6	NUM
admet-373	587	23	4	4	NUM
admet-373	587	24	1.1	1.1	NUM
admet-373	587	25	0.04	0.04	NUM
admet-373	587	26	55.00	55.00	NUM
admet-373	587	27	1.74	1.74	NUM
admet-373	587	28	15.00	15.00	NUM
admet-373	587	29	1.18	1.18	NUM
admet-373	587	30	1.30	1.30	NUM
admet-373	587	31	0.11	0.11	NUM
admet-373	587	32	nisoldipine	nisoldipine	NOUN
admet-373	587	33	test	test	NOUN
admet-373	587	34	20	20	NUM
admet-373	587	35	9.8	9.8	NUM
admet-373	587	36	1	1	NUM
admet-373	587	37	5.5	5.5	NUM
admet-373	587	38	0.74	0.74	NUM
admet-373	587	39	15.00	15.00	NUM
admet-373	587	40	1.18	1.18	NUM
admet-373	587	41	11.00	11.00	NUM
admet-373	587	42	1.04	1.04	NUM
admet-373	587	43	nitrendipine	nitrendipine	ADJ
admet-373	587	44	test	test	NOUN
admet-373	588	1	20	20	NUM
admet-373	588	2	7.6	7.6	NUM
admet-373	588	3	2	2	NUM
admet-373	588	4	6.1	6.1	NUM
admet-373	588	5	0.79	0.79	NUM
admet-373	588	6	305.0	305.0	NUM
admet-373	588	7	2.48	2.48	NUM
admet-373	588	8	25.00	25.00	NUM
admet-373	588	9	1.40	1.40	NUM
admet-373	588	10	8.20	8.20	NUM
admet-373	588	11	0.91	0.91	NUM
admet-373	588	12	nortriptyline	nortriptyline	NOUN
admet-373	588	13	hydrochloride	hydrochloride	NOUN
admet-373	588	14	train	train	NOUN
admet-373	588	15	.	.	PUNCT
admet-373	589	1	75	75	NUM
admet-373	589	2	9	9	NUM
admet-373	589	3	3	3	NUM
admet-373	589	4	22	22	NUM
admet-373	589	5	1.34	1.34	NUM
admet-373	589	6	183.33	183.33	NUM
admet-373	589	7	2.26	2.26	NUM
admet-373	589	8	10.00	10.00	NUM
admet-373	589	9	1.00	1.00	NUM
admet-373	589	10	30.00	30.00	NUM
admet-373	589	11	1.48	1.48	NUM
admet-373	589	12	olanzapine	olanzapine	PROPN
admet-373	589	13	test	test	NOUN
admet-373	589	14	10	10	NUM
admet-373	589	15	7.5	7.5	NUM
admet-373	589	16	1	1	NUM
admet-373	589	17	14.3	14.3	NUM
admet-373	589	18	1.16	1.16	NUM
admet-373	589	19	204.29	204.29	NUM
admet-373	589	20	2.31	2.31	NUM
admet-373	589	21	7.14	7.14	NUM
admet-373	589	22	0.85	0.85	NUM
admet-373	589	23	37.50	37.50	NUM
admet-373	589	24	1.57	1.57	NUM
admet-373	589	25	pentoxifylline	pentoxifylline	NOUN
admet-373	589	26	train	train	NOUN
admet-373	589	27	.	.	PUNCT
admet-373	590	1	800	800	NUM
admet-373	590	2	3.7	3.7	NUM
admet-373	590	3	2	2	NUM
admet-373	590	4	1.8	1.8	NUM
admet-373	590	5	0.26	0.26	NUM
admet-373	590	6	6.00	6.00	NUM
admet-373	590	7	0.78	0.78	NUM
admet-373	590	8	39.00	39.00	NUM
admet-373	590	9	1.59	1.59	NUM
admet-373	590	10	1.20	1.20	NUM
admet-373	590	11	0.08	0.08	NUM
admet-373	590	12	pergolide	pergolide	NOUN
admet-373	590	13	mesylate	mesylate	NOUN
admet-373	590	14	test	test	NOUN
admet-373	590	15	0	0	NUM
admet-373	590	16	8.9	8.9	NUM
admet-373	590	17	1	1	NUM
admet-373	590	18	27.00	27.00	NUM
admet-373	590	19	1.43	1.43	NUM
admet-373	590	20	phenytoin	phenytoin	NOUN
admet-373	590	21	train	train	NOUN
admet-373	590	22	.	.	PUNCT
admet-373	591	1	90	90	NUM
admet-373	591	2	4.2	4.2	NUM
admet-373	591	3	1	1	NUM
admet-373	591	4	22.00	22.00	NUM
admet-373	591	5	1.34	1.34	NUM
admet-373	591	6	pimozide	pimozide	ADJ
admet-373	591	7	test	test	NOUN
admet-373	591	8	8	8	NUM
admet-373	591	9	9.6	9.6	NUM
admet-373	591	10	2	2	NUM
admet-373	591	11	29.30	29.30	NUM
admet-373	591	12	1.47	1.47	NUM
admet-373	591	13	pioglitazone	pioglitazone	NOUN
admet-373	591	14	hydrochloride	hydrochloride	NOUN
admet-373	591	15	test	test	NOUN
admet-373	591	16	15	15	NUM
admet-373	591	17	4.5	4.5	NUM
admet-373	591	18	1	1	NUM
admet-373	591	19	0.63	0.63	NUM
admet-373	591	20	-0.20	-0.20	NUM
admet-373	591	21	63.00	63.00	NUM
admet-373	591	22	1.80	1.80	NUM
admet-373	591	23	5.00	5.00	NUM
admet-373	591	24	0.70	0.70	NUM
admet-373	591	25	piroxicam	piroxicam	NOUN
admet-373	591	26	train	train	NOUN
admet-373	591	27	.	.	PUNCT
admet-373	592	1	20	20	NUM
admet-373	592	2	6.7	6.7	NUM
admet-373	592	3	1	1	NUM
admet-373	592	4	0.14	0.14	NUM
admet-373	592	5	-0.85	-0.85	NUM
admet-373	592	6	2.33	2.33	NUM
admet-373	592	7	0.37	0.37	NUM
admet-373	592	8	58.00	58.00	NUM
admet-373	592	9	1.76	1.76	NUM
admet-373	592	10	pravastatin	pravastatin	NOUN
admet-373	592	11	sodium	sodium	NOUN
admet-373	592	12	test	test	NOUN
admet-373	592	13	40	40	NUM
admet-373	592	14	8.2	8.2	NUM
admet-373	592	15	1	1	NUM
admet-373	592	16	0.46	0.46	NUM
admet-373	592	17	-0.34	-0.34	NOUN
admet-373	592	18	0.92	0.92	NUM
admet-373	592	19	-0.04	-0.04	NUM
admet-373	592	20	14.00	14.00	NUM
admet-373	592	21	1.15	1.15	NUM
admet-373	592	22	0.80	0.80	NUM
admet-373	592	23	-0.10	-0.10	NUM
admet-373	592	24	prazosin	prazosin	NOUN
admet-373	592	25	hydrochloride	hydrochloride	NOUN
admet-373	592	26	train	train	NOUN
admet-373	592	27	.	.	PUNCT
admet-373	593	1	2	2	NUM
admet-373	593	2	8.9	8.9	NUM
admet-373	593	3	3	3	NUM
admet-373	593	4	0.73	0.73	NUM
admet-373	593	5	-0.14	-0.14	NUM
admet-373	593	6	12.17	12.17	NUM
admet-373	593	7	1.09	1.09	NUM
admet-373	593	8	4.70	4.70	NUM
admet-373	593	9	0.67	0.67	NUM
admet-373	593	10	2.00	2.00	NUM
admet-373	593	11	0.30	0.30	NUM
admet-373	593	12	primaquine	primaquine	NOUN
admet-373	593	13	phosphate	phosphate	NOUN
admet-373	593	14	test	test	NOUN
admet-373	593	15	15	15	NUM
admet-373	593	16	5.4	5.4	NUM
admet-373	593	17	1	1	NUM
admet-373	593	18	4	4	NUM
admet-373	593	19	0.60	0.60	NUM
admet-373	593	20	5.80	5.80	NUM
admet-373	593	21	0.76	0.76	NUM
admet-373	593	22	7.10	7.10	NUM
admet-373	593	23	0.85	0.85	NUM
admet-373	593	24	valko	valko	NOUN
admet-373	593	25	,	,	PUNCT
admet-373	593	26	teague	teague	NOUN
admet-373	593	27	and	and	CCONJ
admet-373	593	28	pidgeon	pidgeon	PROPN
admet-373	593	29	admet	admet	PROPN
admet-373	593	30	&	&	CCONJ
admet-373	593	31	dmpk	dmpk	PROPN
admet-373	593	32	5(1	5(1	NUM
admet-373	593	33	)	)	PUNCT
admet-373	593	34	(	(	PUNCT
admet-373	593	35	2017	2017	NUM
admet-373	593	36	)	)	PUNCT
admet-373	593	37	14	14	NUM
admet-373	593	38	-	-	SYM
admet-373	593	39	38	38	NUM
admet-373	593	40	34	34	NUM
admet-373	593	41	probenecid	probenecid	PROPN
admet-373	593	42	train	train	NOUN
admet-373	593	43	.	.	PUNCT
admet-373	594	1	1000	1000	NUM
admet-373	594	2	3.8	3.8	NUM
admet-373	594	3	2	2	NUM
admet-373	594	4	0.13	0.13	NUM
admet-373	594	5	-0.89	-0.89	NUM
admet-373	594	6	1.00	1.00	NUM
admet-373	594	7	0.00	0.00	NUM
admet-373	594	8	0.25	0.25	NUM
admet-373	594	9	-0.60	-0.60	NUM
admet-373	594	10	5.90	5.90	NUM
admet-373	594	11	0.77	0.77	NUM
admet-373	594	12	prochlorperazin	prochlorperazin	NOUN
admet-373	594	13	e	e	NOUN
admet-373	594	14	maleate	maleate	NOUN
admet-373	594	15	test	test	NOUN
admet-373	594	16	15	15	NUM
admet-373	594	17	8.5	8.5	NUM
admet-373	594	18	3	3	NUM
admet-373	594	19	22	22	NUM
admet-373	594	20	1.34	1.34	NUM
admet-373	594	21	16.00	16.00	NUM
admet-373	594	22	1.20	1.20	NUM
admet-373	594	23	9.00	9.00	NUM
admet-373	594	24	0.95	0.95	NUM
admet-373	594	25	procyclidine	procyclidine	NOUN
admet-373	594	26	hydrochloride	hydrochloride	NOUN
admet-373	594	27	test	test	NOUN
admet-373	594	28	8	8	NUM
admet-373	594	29	8.6	8.6	NUM
admet-373	594	30	3	3	NUM
admet-373	594	31	0.74	0.74	NUM
admet-373	594	32	-0.13	-0.13	NUM
admet-373	594	33	0.86	0.86	NUM
admet-373	594	34	-0.07	-0.07	NUM
admet-373	594	35	12.00	12.00	NUM
admet-373	594	36	1.08	1.08	NUM
admet-373	594	37	promethazine	promethazine	NOUN
admet-373	594	38	hydrochloride	hydrochloride	NOUN
admet-373	594	39	test	test	NOUN
admet-373	594	40	50	50	NUM
admet-373	594	41	8.2	8.2	NUM
admet-373	594	42	2	2	NUM
admet-373	594	43	14	14	NUM
admet-373	594	44	1.15	1.15	NUM
admet-373	594	45	155.56	155.56	NUM
admet-373	594	46	2.19	2.19	NUM
admet-373	594	47	14.00	14.00	NUM
admet-373	594	48	1.15	1.15	NUM
admet-373	594	49	14.00	14.00	NUM
admet-373	594	50	1.15	1.15	NUM
admet-373	594	51	propafenone	propafenone	NOUN
admet-373	594	52	hydrochloride	hydrochloride	NOUN
admet-373	594	53	test	test	NOUN
admet-373	594	54	450	450	NUM
admet-373	594	55	5.7	5.7	NUM
admet-373	594	56	3	3	NUM
admet-373	594	57	2.2	2.2	NUM
admet-373	594	58	0.34	0.34	NUM
admet-373	594	59	55.00	55.00	NUM
admet-373	594	60	1.74	1.74	NUM
admet-373	594	61	16.00	16.00	NUM
admet-373	594	62	1.20	1.20	NUM
admet-373	594	63	2.10	2.10	NUM
admet-373	594	64	0.32	0.32	NUM
admet-373	594	65	propranolol	propranolol	PROPN
admet-373	594	66	hcl	hcl	PROPN
admet-373	594	67	train	train	NOUN
admet-373	594	68	.	.	PUNCT
admet-373	595	1	160	160	NUM
admet-373	595	2	9.4	9.4	NUM
admet-373	595	3	2	2	NUM
admet-373	595	4	3.1	3.1	NUM
admet-373	595	5	0.49	0.49	NUM
admet-373	595	6	23.85	23.85	NUM
admet-373	595	7	1.38	1.38	NUM
admet-373	595	8	12.00	12.00	NUM
admet-373	595	9	1.08	1.08	NUM
admet-373	595	10	3.40	3.40	NUM
admet-373	595	11	0.53	0.53	NUM
admet-373	595	12	protriptyline	protriptyline	NOUN
admet-373	595	13	hydrochloride	hydrochloride	NOUN
admet-373	595	14	test	test	NOUN
admet-373	595	15	15	15	NUM
admet-373	595	16	5.6	5.6	NUM
admet-373	595	17	3	3	NUM
admet-373	595	18	22	22	NUM
admet-373	595	19	1.34	1.34	NUM
admet-373	595	20	quinine	quinine	NOUN
admet-373	595	21	sulfate	sulfate	NOUN
admet-373	595	22	train	train	NOUN
admet-373	595	23	.	.	PUNCT
admet-373	596	1	1800	1800	NUM
admet-373	596	2	6.3	6.3	NUM
admet-373	596	3	6	6	NUM
admet-373	596	4	1.8	1.8	NUM
admet-373	596	5	0.26	0.26	NUM
admet-373	596	6	6.00	6.00	NUM
admet-373	596	7	0.78	0.78	NUM
admet-373	596	8	1.90	1.90	NUM
admet-373	596	9	0.28	0.28	NUM
admet-373	596	10	11.00	11.00	NUM
admet-373	596	11	1.04	1.04	NUM
admet-373	596	12	riluzole	riluzole	NOUN
admet-373	596	13	test	test	NOUN
admet-373	596	14	100	100	NUM
admet-373	596	15	4.4	4.4	NUM
admet-373	596	16	2	2	NUM
admet-373	596	17	12.00	12.00	NUM
admet-373	596	18	1.08	1.08	NUM
admet-373	596	19	roxithromycin	roxithromycin	NOUN
admet-373	596	20	test	test	NOUN
admet-373	596	21	450	450	NUM
admet-373	596	22	6.8	6.8	NUM
admet-373	596	23	3	3	NUM
admet-373	596	24	0.00	0.00	NUM
admet-373	596	25	12.00	12.00	NUM
admet-373	596	26	1.08	1.08	NUM
admet-373	596	27	saquinavir	saquinavir	NOUN
admet-373	596	28	test	test	NOUN
admet-373	596	29	2000	2000	NUM
admet-373	596	30	8.3	8.3	NUM
admet-373	596	31	2	2	NUM
admet-373	596	32	3.6	3.6	NUM
admet-373	596	33	0.56	0.56	NUM
admet-373	596	34	120.00	120.00	NUM
admet-373	596	35	2.08	2.08	NUM
admet-373	596	36	13.00	13.00	NUM
admet-373	596	37	1.11	1.11	NUM
admet-373	596	38	13.00	13.00	NUM
admet-373	596	39	1.11	1.11	NUM
admet-373	596	40	simvastatin	simvastatin	ADJ
admet-373	596	41	test	test	NOUN
admet-373	596	42	40	40	NUM
admet-373	596	43	8.4	8.4	NUM
admet-373	596	44	1	1	NUM
admet-373	596	45	3.00	3.00	NUM
admet-373	596	46	0.48	0.48	NUM
admet-373	596	47	sulfinpyrazone	sulfinpyrazone	NOUN
admet-373	596	48	train	train	NOUN
admet-373	596	49	.	.	PUNCT
admet-373	597	1	100	100	NUM
admet-373	597	2	3.3	3.3	NUM
admet-373	597	3	1	1	NUM
admet-373	597	4	0.12	0.12	NUM
admet-373	597	5	-0.92	-0.92	ADP
admet-373	597	6	6.00	6.00	NUM
admet-373	597	7	0.78	0.78	NUM
admet-373	597	8	0.34	0.34	NUM
admet-373	597	9	-0.47	-0.47	DET
admet-373	597	10	6.20	6.20	NUM
admet-373	597	11	0.79	0.79	NUM
admet-373	597	12	sumatriptan	sumatriptan	ADJ
admet-373	597	13	test	test	NOUN
admet-373	597	14	75	75	NUM
admet-373	597	15	8.1	8.1	NUM
admet-373	597	16	3	3	NUM
admet-373	597	17	1.7	1.7	NUM
admet-373	597	18	0.23	0.23	NUM
admet-373	597	19	2.05	2.05	NUM
admet-373	597	20	0.31	0.31	NUM
admet-373	597	21	19.00	19.00	NUM
admet-373	597	22	1.28	1.28	NUM
admet-373	597	23	1.70	1.70	NUM
admet-373	597	24	0.23	0.23	NUM
admet-373	597	25	tamsulosin	tamsulosin	NOUN
admet-373	597	26	hydrochloride	hydrochloride	NOUN
admet-373	597	27	test	test	NOUN
admet-373	597	28	2	2	NUM
admet-373	597	29	11	11	NUM
admet-373	597	30	2	2	NUM
admet-373	597	31	0.21	0.21	NUM
admet-373	597	32	-0.68	-0.68	NOUN
admet-373	597	33	21.00	21.00	NUM
admet-373	597	34	1.32	1.32	NUM
admet-373	597	35	0.62	0.62	NUM
admet-373	597	36	-0.21	-0.21	NUM
admet-373	597	37	6.80	6.80	NUM
admet-373	597	38	0.83	0.83	NUM
admet-373	597	39	trazodone	trazodone	NOUN
admet-373	597	40	hydrochloride	hydrochloride	NOUN
admet-373	597	41	train	train	NOUN
admet-373	597	42	.	.	PUNCT
admet-373	598	1	150	150	NUM
admet-373	598	2	6.3	6.3	NUM
admet-373	598	3	1	1	NUM
admet-373	598	4	0.52	0.52	NUM
admet-373	598	5	-0.28	-0.28	NUM
admet-373	598	6	1.40	1.40	NUM
admet-373	598	7	0.15	0.15	NUM
admet-373	598	8	7.30	7.30	NUM
admet-373	598	9	0.86	0.86	NUM
admet-373	598	10	venlafaxine	venlafaxine	ADJ
admet-373	598	11	hydrochloride	hydrochloride	NOUN
admet-373	598	12	test	test	NOUN
admet-373	598	13	75	75	NUM
admet-373	598	14	7.7	7.7	NUM
admet-373	598	15	2	2	NUM
admet-373	598	16	4.4	4.4	NUM
admet-373	598	17	0.64	0.64	NUM
admet-373	598	18	6.03	6.03	NUM
admet-373	598	19	0.78	0.78	NUM
admet-373	598	20	14.00	14.00	NUM
admet-373	598	21	1.15	1.15	NUM
admet-373	598	22	5.00	5.00	NUM
admet-373	598	23	0.70	0.70	NUM
admet-373	598	24	verapamil	verapamil	NOUN
admet-373	598	25	hydrochloride	hydrochloride	NOUN
admet-373	598	26	test	test	NOUN
admet-373	598	27	120	120	NUM
admet-373	598	28	6.9	6.9	NUM
admet-373	598	29	3	3	NUM
admet-373	598	30	3.7	3.7	NUM
admet-373	598	31	0.57	0.57	NUM
admet-373	598	32	41.11	41.11	NUM
admet-373	598	33	1.61	1.61	NUM
admet-373	598	34	18.00	18.00	NUM
admet-373	598	35	1.26	1.26	NUM
admet-373	598	36	2.80	2.80	NUM
admet-373	598	37	0.45	0.45	NUM
admet-373	598	38	table	table	NOUN
admet-373	598	39	a2	a2	PROPN
admet-373	598	40	.	.	PUNCT
admet-373	599	1	measured	measure	VERB
admet-373	599	2	biomimetic	biomimetic	ADJ
admet-373	599	3	properties	property	NOUN
admet-373	599	4	and	and	CCONJ
admet-373	599	5	estimated	estimate	VERB
admet-373	599	6	volume	volume	NOUN
admet-373	599	7	of	of	ADP
admet-373	599	8	distribution	distribution	NOUN
admet-373	599	9	,	,	PUNCT
admet-373	599	10	unbound	unbound	NOUN
admet-373	599	11	volume	volume	NOUN
admet-373	599	12	of	of	ADP
admet-373	599	13	distribution	distribution	NOUN
admet-373	599	14	based	base	VERB
admet-373	599	15	on	on	ADP
admet-373	599	16	the	the	DET
admet-373	599	17	published	publish	VERB
admet-373	599	18	models	model	NOUN
admet-373	599	19	.	.	PUNCT
admet-373	600	1	%	%	INTJ
admet-373	600	2	hsa	hsa	PROPN
admet-373	600	3	binding	bind	VERB
admet-373	600	4	is	be	AUX
admet-373	600	5	obtained	obtain	VERB
admet-373	600	6	from	from	ADP
admet-373	600	7	the	the	DET
admet-373	600	8	log	log	NOUN
admet-373	600	9	tr	tr	VERB
admet-373	600	10	vs	vs	ADP
admet-373	600	11	log	log	NOUN
admet-373	600	12	k(hsa	k(hsa	NOUN
admet-373	600	13	)	)	PUNCT
admet-373	600	14	calibration	calibration	NOUN
admet-373	600	15	plot	plot	NOUN
admet-373	600	16	using	use	VERB
admet-373	600	17	%	%	NOUN
admet-373	600	18	hsa=	hsa=	VERB
admet-373	600	19	101	101	NUM
admet-373	600	20	*	*	SYM
admet-373	600	21	10	10	NUM
admet-373	600	22	logk(hsa	logk(hsa	NOUN
admet-373	600	23	)	)	PUNCT
admet-373	600	24	/(1	/(1	PUNCT
admet-373	601	1	+	+	PROPN
admet-373	601	2	10	10	NUM
admet-373	601	3	logk(hsa	logk(hsa	NOUN
admet-373	601	4	)	)	PUNCT
admet-373	601	5	)	)	PUNCT
admet-373	601	6	,	,	PUNCT
admet-373	601	7	log	log	PROPN
admet-373	601	8	k(hsa)=	k(hsa)=	PROPN
admet-373	601	9	exp(logk(hsa	exp(logk(hsa	PROPN
admet-373	601	10	)	)	PUNCT
admet-373	601	11	;	;	PUNCT
admet-373	601	12	log	log	PROPN
admet-373	601	13	k(iam	k(iam	PROPN
admet-373	601	14	)	)	PUNCT
admet-373	601	15	obtained	obtain	VERB
admet-373	601	16	from	from	ADP
admet-373	601	17	measured	measure	VERB
admet-373	601	18	iam	iam	PROPN
admet-373	601	19	mb	mb	PROPN
admet-373	601	20	as	as	SCONJ
admet-373	601	21	described	describe	VERB
admet-373	601	22	by	by	ADP
admet-373	601	23	equation	equation	NOUN
admet-373	601	24	(	(	PUNCT
admet-373	601	25	1	1	NUM
admet-373	601	26	)	)	PUNCT
admet-373	601	27	;	;	PUNCT
admet-373	601	28	iam	iam	PROPN
admet-373	601	29	mb	mb	PROPN
admet-373	601	30	/	/	SYM
admet-373	601	31	pb	pb	ADP
admet-373	601	32	demax	demax	NOUN
admet-373	601	33	is	be	AUX
admet-373	601	34	calculated	calculate	VERB
admet-373	601	35	from	from	ADP
admet-373	601	36	vdu	vdu	PROPN
admet-373	601	37	as	as	ADP
admet-373	601	38	100	100	NUM
admet-373	601	39	/	/	SYM
admet-373	601	40	vdu	vdu	PROPN
admet-373	601	41	where	where	SCONJ
admet-373	601	42	log	log	PROPN
admet-373	601	43	vdu	vdu	PROPN
admet-373	601	44	is	be	AUX
admet-373	601	45	obtained	obtain	VERB
admet-373	601	46	as	as	ADP
admet-373	601	47	a	a	DET
admet-373	601	48	sum	sum	NOUN
admet-373	601	49	of	of	ADP
admet-373	601	50	log	log	NOUN
admet-373	601	51	k(iam	k(iam	PROPN
admet-373	601	52	)	)	PUNCT
admet-373	601	53	and	and	CCONJ
admet-373	601	54	log	log	VERB
admet-373	601	55	k(hsa	k(hsa	NOUN
admet-373	601	56	)	)	PUNCT
admet-373	601	57	according	accord	VERB
admet-373	601	58	to	to	ADP
admet-373	601	59	equation	equation	NOUN
admet-373	601	60	(	(	PUNCT
admet-373	601	61	4	4	NUM
admet-373	601	62	)	)	PUNCT
admet-373	601	63	;	;	PUNCT
admet-373	601	64	iam	iam	PROPN
admet-373	601	65	mb	mb	PROPN
admet-373	601	66	/	/	SYM
admet-373	601	67	pb	pb	X
admet-373	601	68	log	log	NOUN
admet-373	601	69	vdss	vdss	ADV
admet-373	601	70	is	be	AUX
admet-373	601	71	obtained	obtain	VERB
admet-373	601	72	from	from	ADP
admet-373	601	73	the	the	DET
admet-373	601	74	difference	difference	NOUN
admet-373	601	75	between	between	ADP
admet-373	601	76	log	log	NOUN
admet-373	601	77	k(iam	k(iam	PROPN
admet-373	601	78	)	)	PUNCT
admet-373	601	79	and	and	CCONJ
admet-373	601	80	log	log	VERB
admet-373	601	81	k(hsa	k(hsa	NOUN
admet-373	601	82	)	)	PUNCT
admet-373	601	83	as	as	SCONJ
admet-373	601	84	described	describe	VERB
admet-373	601	85	by	by	ADP
admet-373	601	86	equation	equation	NOUN
admet-373	601	87	3	3	NUM
admet-373	601	88	.	.	PUNCT
admet-373	602	1	the	the	DET
admet-373	602	2	test	test	NOUN
admet-373	602	3	/	/	SYM
admet-373	602	4	training	training	NOUN
admet-373	602	5	marks	mark	NOUN
admet-373	602	6	are	be	AUX
admet-373	602	7	based	base	VERB
admet-373	602	8	whether	whether	SCONJ
admet-373	602	9	it	it	PRON
admet-373	602	10	was	be	AUX
admet-373	602	11	used	use	VERB
admet-373	602	12	in	in	ADP
admet-373	602	13	the	the	DET
admet-373	602	14	model	model	NOUN
admet-373	602	15	building	building	NOUN
admet-373	602	16	for	for	ADP
admet-373	602	17	vdu	vdu	PROPN
admet-373	603	1	[	[	X
admet-373	603	2	43	43	NUM
admet-373	603	3	]	]	PUNCT
admet-373	603	4	.	.	PUNCT
admet-373	604	1	drug	drug	NOUN
admet-373	604	2	test	test	NOUN
admet-373	604	3	or	or	CCONJ
admet-373	604	4	training	training	NOUN
admet-373	604	5	set	set	NOUN
admet-373	604	6	of	of	ADP
admet-373	604	7	compound	compound	NOUN
admet-373	604	8	%	%	NOUN
admet-373	604	9	hsa	hsa	AUX
admet-373	604	10	binding	bind	VERB
admet-373	604	11	log	log	NOUN
admet-373	604	12	k(has	k(ha	NOUN
admet-373	604	13	)	)	PUNCT
admet-373	604	14	converted	convert	VERB
admet-373	604	15	to	to	PART
admet-373	604	16	log	log	VERB
admet-373	604	17	p	p	NOUN
admet-373	604	18	scale	scale	NOUN
admet-373	604	19	log	log	NOUN
admet-373	604	20	k	k	PROPN
admet-373	604	21	(	(	PUNCT
admet-373	604	22	iam	iam	PROPN
admet-373	604	23	)	)	PUNCT
admet-373	604	24	converted	convert	VERB
admet-373	604	25	to	to	PART
admet-373	604	26	log	log	VERB
admet-373	604	27	p	p	NOUN
admet-373	604	28	scale	scale	NOUN
admet-373	604	29	iam	iam	PROPN
admet-373	604	30	mb	mb	PROPN
admet-373	604	31	/	/	SYM
admet-373	604	32	pb	pb	ADP
admet-373	604	33	demax	demax	NOUN
admet-373	604	34	(	(	PUNCT
admet-373	604	35	%	%	INTJ
admet-373	604	36	)	)	PUNCT
admet-373	604	37	iam	iam	PROPN
admet-373	604	38	mb	mb	PROPN
admet-373	604	39	/	/	SYM
admet-373	604	40	pb	pb	NOUN
admet-373	604	41	log	log	NOUN
admet-373	604	42	vdu	vdu	PROPN
admet-373	604	43	iam	iam	PROPN
admet-373	604	44	mb	mb	PROPN
admet-373	604	45	/	/	SYM
admet-373	604	46	pb	pb	ADP
admet-373	604	47	logvdss	logvdss	NOUN
admet-373	604	48	acid	acid	NOUN
admet-373	604	49	/	/	SYM
admet-373	604	50	base	base	NOUN
admet-373	604	51	character	character	NOUN
admet-373	604	52	abacavir	abacavir	AUX
admet-373	604	53	test	test	VERB
admet-373	604	54	31.9	31.9	NUM
admet-373	604	55	0.71	0.71	NUM
admet-373	604	56	1.77	1.77	NUM
admet-373	604	57	60.9	60.9	NUM
admet-373	604	58	0.21	0.21	NUM
admet-373	604	59	-0.04	-0.04	NUM
admet-373	604	60	weak	weak	ADJ
admet-373	604	61	base	base	NOUN
admet-373	604	62	acebutolol	acebutolol	NOUN
admet-373	604	63	hydrochloride	hydrochloride	NOUN
admet-373	604	64	test	test	NOUN
admet-373	604	65	32.7	32.7	NUM
admet-373	604	66	0.73	0.73	NUM
admet-373	604	67	1.59	1.59	NUM
admet-373	604	68	72.1	72.1	NUM
admet-373	604	69	0.13	0.13	NUM
admet-373	604	70	-0.12	-0.12	NUM
admet-373	604	71	basic	basic	ADJ
admet-373	604	72	acetylsalicylic	acetylsalicylic	NOUN
admet-373	604	73	acid	acid	PROPN
admet-373	604	74	test	test	NOUN
admet-373	604	75	66.4	66.4	NUM
admet-373	604	76	1.33	1.33	NUM
admet-373	604	77	acidic	acidic	ADJ
admet-373	604	78	acrivastine	acrivastine	ADJ
admet-373	604	79	test	test	NOUN
admet-373	604	80	82.5	82.5	NUM
admet-373	604	81	1.91	1.91	NUM
admet-373	604	82	2.68	2.68	NUM
admet-373	604	83	13.2	13.2	NUM
admet-373	604	84	0.87	0.87	NUM
admet-373	604	85	0.10	0.10	NUM
admet-373	604	86	weak	weak	ADJ
admet-373	604	87	base	base	NOUN
admet-373	604	88	admet	admet	NOUN
admet-373	604	89	&	&	CCONJ
admet-373	604	90	dmpk	dmpk	PROPN
admet-373	604	91	5(1	5(1	NUM
admet-373	604	92	)	)	PUNCT
admet-373	604	93	(	(	PUNCT
admet-373	604	94	2017	2017	NUM
admet-373	604	95	)	)	PUNCT
admet-373	604	96	14	14	NUM
admet-373	604	97	-	-	SYM
admet-373	604	98	38	38	NUM
admet-373	604	99	in	in	ADP
admet-373	604	100	vitro	vitro	X
admet-373	604	101	membrane	membrane	NOUN
admet-373	604	102	and	and	CCONJ
admet-373	604	103	protein	protein	NOUN
admet-373	604	104	binding	bind	VERB
admet-373	604	105	doi	doi	NOUN
admet-373	604	106	:	:	PUNCT
admet-373	604	107	10.5599	10.5599	NUM
admet-373	604	108	/	/	SYM
admet-373	604	109	admet.5.1.373	admet.5.1.373	ADP
admet-373	604	110	35	35	NUM
admet-373	604	111	albuterol	albuterol	NOUN
admet-373	604	112	sulfate	sulfate	NOUN
admet-373	604	113	test	test	NOUN
admet-373	604	114	22	22	NUM
admet-373	604	115	0.57	0.57	NUM
admet-373	604	116	1.55	1.55	NUM
admet-373	604	117	81.6	81.6	NUM
admet-373	604	118	0.08	0.08	NUM
admet-373	604	119	-0.10	-0.10	NUM
admet-373	604	120	basic	basic	ADJ
admet-373	604	121	allopurinol	allopurinol	NOUN
admet-373	604	122	19.2	19.2	NUM
admet-373	604	123	0.53	0.53	NUM
admet-373	604	124	2	2	NUM
admet-373	604	125	54.9	54.9	NUM
admet-373	604	126	0.26	0.26	NUM
admet-373	604	127	0.10	0.10	NUM
admet-373	604	128	acidic	acidic	ADJ
admet-373	604	129	alosetron	alosetron	ADJ
admet-373	604	130	hydrochloride	hydrochloride	NOUN
admet-373	604	131	test	test	NOUN
admet-373	604	132	75.5	75.5	NUM
admet-373	604	133	1.60	1.60	NUM
admet-373	604	134	2.68	2.68	NUM
admet-373	604	135	15.8	15.8	NUM
admet-373	604	136	0.80	0.80	NUM
admet-373	604	137	0.17	0.17	NUM
admet-373	604	138	weak	weak	ADJ
admet-373	604	139	base	base	NOUN
admet-373	604	140	amiloride	amiloride	ADJ
admet-373	604	141	hydrochloride	hydrochloride	NOUN
admet-373	604	142	training	train	VERB
admet-373	604	143	38.6	38.6	NUM
admet-373	604	144	0.81	0.81	NUM
admet-373	604	145	2.56	2.56	NUM
admet-373	604	146	27.3	27.3	NUM
admet-373	604	147	0.57	0.57	NUM
admet-373	604	148	0.29	0.29	NUM
admet-373	604	149	acidic	acidic	ADJ
admet-373	604	150	aminoglutethimide	aminoglutethimide	NOUN
admet-373	604	151	training	train	VERB
admet-373	604	152	25.9	25.9	NUM
admet-373	604	153	0.63	0.63	NUM
admet-373	604	154	1.53	1.53	NUM
admet-373	605	1	81	81	NUM
admet-373	605	2	0.08	0.08	NUM
admet-373	605	3	-0.13	-0.13	NUM
admet-373	605	4	weak	weak	ADJ
admet-373	605	5	base	base	NOUN
admet-373	605	6	amitriptyline	amitriptyline	NOUN
admet-373	605	7	hydrochloride	hydrochloride	NOUN
admet-373	605	8	test	test	NOUN
admet-373	605	9	90.1	90.1	NUM
admet-373	605	10	2.50	2.50	NUM
admet-373	605	11	6.3	6.3	NUM
admet-373	605	12	0.308	0.308	NUM
admet-373	605	13	2.56	2.56	NUM
admet-373	605	14	1.56	1.56	NUM
admet-373	605	15	basic	basic	ADJ
admet-373	605	16	amoxapine	amoxapine	PROPN
admet-373	605	17	test	test	NOUN
admet-373	605	18	88.4	88.4	NUM
admet-373	605	19	2.33	2.33	NUM
admet-373	605	20	6.64	6.64	NUM
admet-373	605	21	0.24	0.24	NUM
admet-373	605	22	2.67	2.67	NUM
admet-373	605	23	1.75	1.75	NUM
admet-373	605	24	basic	basic	ADJ
admet-373	605	25	aripiprazole	aripiprazole	NOUN
admet-373	605	26	test	test	NOUN
admet-373	605	27	97.8	97.8	NUM
admet-373	605	28	4.42	4.42	NUM
admet-373	605	29	6.08	6.08	NUM
admet-373	605	30	0.129	0.129	NUM
admet-373	605	31	2.91	2.91	NUM
admet-373	605	32	1.04	1.04	NUM
admet-373	605	33	basic	basic	ADJ
admet-373	605	34	atomoxetine	atomoxetine	NOUN
admet-373	605	35	hydrochloride1	hydrochloride1	NOUN
admet-373	605	36	test	test	NOUN
admet-373	605	37	87.5	87.5	NUM
admet-373	605	38	2.25	2.25	NUM
admet-373	605	39	5.28	5.28	NUM
admet-373	605	40	0.922	0.922	NUM
admet-373	605	41	2.07	2.07	NUM
admet-373	605	42	1.17	1.17	NUM
admet-373	605	43	basic	basic	ADJ
admet-373	605	44	bendroflumethiazide	bendroflumethiazide	NOUN
admet-373	605	45	test	test	NOUN
admet-373	605	46	64.4	64.4	NUM
admet-373	605	47	1.28	1.28	NUM
admet-373	605	48	2.95	2.95	NUM
admet-373	605	49	12.7	12.7	NUM
admet-373	605	50	0.84	0.84	NUM
admet-373	605	51	0.36	0.36	NUM
admet-373	605	52	weak	weak	ADJ
admet-373	605	53	acid	acid	NOUN
admet-373	605	54	bicalutamide	bicalutamide	NOUN
admet-373	605	55	test	test	NOUN
admet-373	606	1	96.8	96.8	NUM
admet-373	606	2	3.91	3.91	NUM
admet-373	606	3	3.21	3.21	NUM
admet-373	606	4	2.66	2.66	NUM
admet-373	606	5	1.56	1.56	NUM
admet-373	606	6	-0.11	-0.11	ADJ
admet-373	606	7	neutral	neutral	ADJ
admet-373	606	8	bupropion	bupropion	NOUN
admet-373	606	9	hydrochloride	hydrochloride	NOUN
admet-373	606	10	test	test	NOUN
admet-373	606	11	73.9	73.9	NUM
admet-373	606	12	1.55	1.55	NUM
admet-373	606	13	3.21	3.21	NUM
admet-373	606	14	9.7	9.7	NUM
admet-373	606	15	1.02	1.02	NUM
admet-373	606	16	0.41	0.41	NUM
admet-373	606	17	basic	basic	ADJ
admet-373	606	18	cabergoline	cabergoline	NOUN
admet-373	606	19	test	test	NOUN
admet-373	606	20	83.6	83.6	NUM
admet-373	606	21	1.98	1.98	NUM
admet-373	606	22	6.41	6.41	NUM
admet-373	606	23	0.366	0.366	NUM
admet-373	606	24	2.49	2.49	NUM
admet-373	606	25	1.73	1.73	NUM
admet-373	606	26	basic	basic	ADJ
admet-373	606	27	caffeine	caffeine	NOUN
admet-373	606	28	test	test	NOUN
admet-373	606	29	26.8	26.8	NUM
admet-373	606	30	0.64	0.64	NUM
admet-373	606	31	1.22	1.22	NUM
admet-373	606	32	108	108	NUM
admet-373	606	33	-0.05	-0.05	NUM
admet-373	606	34	-0.26	-0.26	X
admet-373	606	35	neutral	neutral	ADJ
admet-373	606	36	candesartan	candesartan	PROPN
admet-373	606	37	cilexetil	cilexetil	PROPN
admet-373	606	38	test	test	NOUN
admet-373	606	39	97.9	97.9	NUM
admet-373	606	40	4.48	4.48	NUM
admet-373	606	41	3.8	3.8	NUM
admet-373	606	42	1.07	1.07	NUM
admet-373	606	43	1.94	1.94	NUM
admet-373	606	44	0.03	0.03	NUM
admet-373	606	45	acidic	acidic	ADJ
admet-373	606	46	carbamazepine	carbamazepine	NOUN
admet-373	606	47	test	test	NOUN
admet-373	606	48	79.9	79.9	NUM
admet-373	606	49	1.78	1.78	NUM
admet-373	606	50	2.34	2.34	NUM
admet-373	606	51	19.7	19.7	NUM
admet-373	606	52	0.70	0.70	NUM
admet-373	606	53	-0.02	-0.02	NUM
admet-373	606	54	neutral	neutral	ADJ
admet-373	606	55	celecoxib	celecoxib	NOUN
admet-373	606	56	test	test	NOUN
admet-373	606	57	97.1	97.1	NUM
admet-373	606	58	4.04	4.04	NUM
admet-373	606	59	3.9	3.9	NUM
admet-373	606	60	1.24	1.24	NUM
admet-373	606	61	1.89	1.89	NUM
admet-373	606	62	0.17	0.17	NUM
admet-373	606	63	neutral	neutral	ADJ
admet-373	606	64	cilostazol	cilostazol	ADJ
admet-373	606	65	test	test	NOUN
admet-373	606	66	89.9	89.9	NUM
admet-373	606	67	2.48	2.48	NUM
admet-373	606	68	3.02	3.02	NUM
admet-373	606	69	6.97	6.97	NUM
admet-373	606	70	1.15	1.15	NUM
admet-373	606	71	0.12	0.12	NUM
admet-373	606	72	citalopram	citalopram	PROPN
admet-373	606	73	hydrobromide	hydrobromide	PROPN
admet-373	606	74	test	test	NOUN
admet-373	606	75	72.4	72.4	NUM
admet-373	606	76	1.50	1.50	NUM
admet-373	606	77	4.85	4.85	NUM
admet-373	606	78	2.12	2.12	NUM
admet-373	606	79	1.71	1.71	NUM
admet-373	606	80	1.14	1.14	NUM
admet-373	606	81	basic	basic	ADJ
admet-373	606	82	clomipramine	clomipramine	NOUN
admet-373	606	83	hydrochloride	hydrochloride	NOUN
admet-373	606	84	test	test	NOUN
admet-373	606	85	94.4	94.4	NUM
admet-373	606	86	3.18	3.18	NUM
admet-373	606	87	7.6	7.6	NUM
admet-373	606	88	0.06	0.06	NUM
admet-373	606	89	3.28	3.28	NUM
admet-373	606	90	1.99	1.99	NUM
admet-373	606	91	basic	basic	ADJ
admet-373	606	92	clonidine	clonidine	NOUN
admet-373	606	93	hydrochloride	hydrochloride	NOUN
admet-373	606	94	test	test	NOUN
admet-373	606	95	37.7	37.7	NUM
admet-373	606	96	0.80	0.80	NUM
admet-373	606	97	1.96	1.96	NUM
admet-373	606	98	48.9	48.9	NUM
admet-373	606	99	0.31	0.31	NUM
admet-373	606	100	0.03	0.03	NUM
admet-373	606	101	basic	basic	ADJ
admet-373	606	102	dapsone	dapsone	NOUN
admet-373	606	103	test	test	NOUN
admet-373	606	104	80.6	80.6	NUM
admet-373	606	105	1.82	1.82	NUM
admet-373	606	106	2.07	2.07	NUM
admet-373	606	107	25	25	NUM
admet-373	606	108	0.59	0.59	NUM
admet-373	606	109	-0.15	-0.15	NUM
admet-373	606	110	neutral	neutral	ADJ
admet-373	606	111	desloratadine	desloratadine	PROPN
admet-373	606	112	test	test	NOUN
admet-373	606	113	88.5	88.5	NUM
admet-373	606	114	2.34	2.34	NUM
admet-373	606	115	6.13	6.13	NUM
admet-373	606	116	0.39	0.39	NUM
admet-373	606	117	2.45	2.45	NUM
admet-373	606	118	1.52	1.52	NUM
admet-373	606	119	basic	basic	ADJ
admet-373	606	120	diazoxide	diazoxide	NOUN
admet-373	606	121	training	train	VERB
admet-373	606	122	77.6	77.6	NUM
admet-373	606	123	1.68	1.68	NUM
admet-373	606	124	2.05	2.05	NUM
admet-373	606	125	27.3	27.3	NUM
admet-373	606	126	0.55	0.55	NUM
admet-373	606	127	-0.13	-0.13	NUM
admet-373	606	128	acidic	acidic	ADJ
admet-373	606	129	didanosine	didanosine	PROPN
admet-373	606	130	test	test	NOUN
admet-373	606	131	27.5	27.5	NUM
admet-373	606	132	0.65	0.65	NUM
admet-373	606	133	weak	weak	ADJ
admet-373	606	134	acid	acid	NOUN
admet-373	606	135	diflunisal	diflunisal	NOUN
admet-373	606	136	test	test	NOUN
admet-373	606	137	98.8	98.8	NUM
admet-373	606	138	5.22	5.22	NUM
admet-373	606	139	2.49	2.49	NUM
admet-373	606	140	2.57	2.57	NUM
admet-373	606	141	1.55	1.55	NUM
admet-373	606	142	-0.71	-0.71	NOUN
admet-373	606	143	acidic	acidic	ADJ
admet-373	606	144	diphenhydramine	diphenhydramine	NOUN
admet-373	606	145	hydrochloride	hydrochloride	NOUN
admet-373	606	146	test	test	NOUN
admet-373	606	147	68.7	68.7	NUM
admet-373	606	148	1.39	1.39	NUM
admet-373	606	149	2.98	2.98	NUM
admet-373	606	150	13.3	13.3	NUM
admet-373	606	151	0.88	0.88	NUM
admet-373	606	152	0.35	0.35	NUM
admet-373	606	153	basic	basic	ADJ
admet-373	606	154	dipyridamole	dipyridamole	NOUN
admet-373	606	155	test	test	NOUN
admet-373	606	156	88.2	88.2	NUM
admet-373	606	157	2.31	2.31	NUM
admet-373	606	158	4.03	4.03	NUM
admet-373	606	159	2.93	2.93	NUM
admet-373	606	160	1.54	1.54	NUM
admet-373	606	161	0.60	0.60	NUM
admet-373	606	162	weak	weak	ADJ
admet-373	606	163	base	base	NOUN
admet-373	606	164	domperidone	domperidone	NOUN
admet-373	606	165	test	test	NOUN
admet-373	606	166	92.2	92.2	NUM
admet-373	606	167	2.77	2.77	NUM
admet-373	606	168	3.96	3.96	NUM
admet-373	606	169	2.43	2.43	NUM
admet-373	606	170	1.62	1.62	NUM
admet-373	606	171	0.47	0.47	NUM
admet-373	606	172	basic	basic	ADJ
admet-373	606	173	donepezil	donepezil	NOUN
admet-373	606	174	hydrochloride	hydrochloride	NOUN
admet-373	606	175	test	test	NOUN
admet-373	606	176	86.1	86.1	NUM
admet-373	606	177	2.14	2.14	NUM
admet-373	606	178	3.68	3.68	NUM
admet-373	606	179	4.45	4.45	NUM
admet-373	606	180	1.36	1.36	NUM
admet-373	606	181	0.49	0.49	NUM
admet-373	606	182	basic	basic	ADJ
admet-373	606	183	efavirenz	efavirenz	NOUN
admet-373	606	184	test	test	NOUN
admet-373	606	185	97.3	97.3	NUM
admet-373	606	186	4.14	4.14	NUM
admet-373	606	187	4.34	4.34	NUM
admet-373	606	188	0.777	0.777	NUM
admet-373	606	189	2.10	2.10	NUM
admet-373	606	190	0.34	0.34	NUM
admet-373	606	191	etodolac	etodolac	NOUN
admet-373	606	192	test	test	NOUN
admet-373	606	193	95.6	95.6	NUM
admet-373	606	194	3.48	3.48	NUM
admet-373	606	195	2.51	2.51	NUM
admet-373	606	196	6.52	6.52	NUM
admet-373	606	197	1.16	1.16	NUM
admet-373	606	198	-0.32	-0.32	VERB
admet-373	606	199	acidic	acidic	ADJ
admet-373	606	200	felbamate	felbamate	NOUN
admet-373	606	201	test	test	NOUN
admet-373	606	202	68.7	68.7	NUM
admet-373	606	203	1.39	1.39	NUM
admet-373	606	204	1.76	1.76	NUM
admet-373	606	205	42.3	42.3	NUM
admet-373	606	206	0.36	0.36	NUM
admet-373	606	207	-0.19	-0.19	NUM
admet-373	606	208	neutral	neutral	ADJ
admet-373	606	209	felodipine	felodipine	ADJ
admet-373	606	210	test	test	NOUN
admet-373	606	211	95.9	95.9	NUM
admet-373	606	212	3.58	3.58	NUM
admet-373	606	213	4.45	4.45	NUM
admet-373	606	214	0.965	0.965	NUM
admet-373	606	215	2.02	2.02	NUM
admet-373	606	216	0.51	0.51	NUM
admet-373	606	217	neutral	neutral	ADJ
admet-373	606	218	valko	valko	NOUN
admet-373	606	219	,	,	PUNCT
admet-373	606	220	teague	teague	NOUN
admet-373	606	221	and	and	CCONJ
admet-373	606	222	pidgeon	pidgeon	PROPN
admet-373	606	223	admet	admet	PROPN
admet-373	606	224	&	&	CCONJ
admet-373	606	225	dmpk	dmpk	PROPN
admet-373	606	226	5(1	5(1	NUM
admet-373	606	227	)	)	PUNCT
admet-373	606	228	(	(	PUNCT
admet-373	606	229	2017	2017	NUM
admet-373	606	230	)	)	PUNCT
admet-373	606	231	14	14	NUM
admet-373	606	232	-	-	SYM
admet-373	606	233	38	38	NUM
admet-373	606	234	36	36	NUM
admet-373	606	235	fexofenadine	fexofenadine	NOUN
admet-373	606	236	hydrochloride	hydrochloride	NOUN
admet-373	606	237	test	test	NOUN
admet-373	606	238	74.1	74.1	NUM
admet-373	606	239	1.55	1.55	NUM
admet-373	606	240	2.64	2.64	NUM
admet-373	606	241	16.6	16.6	NUM
admet-373	606	242	0.77	0.77	NUM
admet-373	606	243	0.16	0.16	NUM
admet-373	606	244	basic	basic	ADJ
admet-373	606	245	finasteride	finasteride	ADJ
admet-373	606	246	test	test	NOUN
admet-373	606	247	88.4	88.4	NUM
admet-373	606	248	2.33	2.33	NUM
admet-373	606	249	3.34	3.34	NUM
admet-373	606	250	5.55	5.55	NUM
admet-373	606	251	1.25	1.25	NUM
admet-373	606	252	0.30	0.30	NUM
admet-373	606	253	fluoxetine	fluoxetine	NOUN
admet-373	606	254	hydrochloride	hydrochloride	NOUN
admet-373	606	255	test	test	NOUN
admet-373	606	256	91.2	91.2	NUM
admet-373	606	257	2.63	2.63	NUM
admet-373	606	258	6.19	6.19	NUM
admet-373	606	259	0.305	0.305	NUM
admet-373	606	260	2.55	2.55	NUM
admet-373	606	261	1.48	1.48	NUM
admet-373	606	262	basic	basic	ADJ
admet-373	606	263	flurbiprofen	flurbiprofen	NOUN
admet-373	606	264	test	test	NOUN
admet-373	606	265	98.6	98.6	NUM
admet-373	606	266	5.02	5.02	NUM
admet-373	606	267	1.99	1.99	NUM
admet-373	606	268	4.77	4.77	NUM
admet-373	606	269	1.29	1.29	NUM
admet-373	606	270	-0.89	-0.89	NUM
admet-373	606	271	acidic	acidic	ADJ
admet-373	606	272	flutamide	flutamide	NOUN
admet-373	606	273	test	test	NOUN
admet-373	606	274	94.3	94.3	NUM
admet-373	606	275	3.15	3.15	NUM
admet-373	606	276	3.48	3.48	NUM
admet-373	606	277	3.11	3.11	NUM
admet-373	606	278	1.50	1.50	NUM
admet-373	606	279	0.18	0.18	NUM
admet-373	606	280	neutral	neutral	ADJ
admet-373	606	281	fluvoxamine	fluvoxamine	PROPN
admet-373	606	282	maleate	maleate	PROPN
admet-373	606	283	test	test	NOUN
admet-373	606	284	72.3	72.3	NUM
admet-373	606	285	1.49	1.49	NUM
admet-373	606	286	5.15	5.15	NUM
admet-373	606	287	1.59	1.59	NUM
admet-373	606	288	1.84	1.84	NUM
admet-373	606	289	1.28	1.28	NUM
admet-373	606	290	basic	basic	ADJ
admet-373	606	291	furosemide	furosemide	ADJ
admet-373	606	292	test	test	NOUN
admet-373	606	293	89.7	89.7	NUM
admet-373	606	294	2.46	2.46	NUM
admet-373	606	295	2.14	2.14	NUM
admet-373	606	296	12.4	12.4	NUM
admet-373	606	297	0.77	0.77	NUM
admet-373	606	298	-0.26	-0.26	NOUN
admet-373	606	299	acidic	acidic	ADJ
admet-373	606	300	glibenclamide	glibenclamide	ADJ
admet-373	606	301	test	test	NOUN
admet-373	606	302	98	98	NUM
admet-373	606	303	4.55	4.55	NUM
admet-373	606	304	2.7	2.7	NUM
admet-373	606	305	2.99	2.99	NUM
admet-373	606	306	1.49	1.49	NUM
admet-373	606	307	-0.47	-0.47	DET
admet-373	606	308	acidic	acidic	ADJ
admet-373	606	309	glimepiride	glimepiride	NOUN
admet-373	606	310	test	test	NOUN
admet-373	606	311	98	98	NUM
admet-373	606	312	4.55	4.55	NUM
admet-373	606	313	2.53	2.53	NUM
admet-373	606	314	3.61	3.61	NUM
admet-373	606	315	1.41	1.41	NUM
admet-373	606	316	-0.55	-0.55	NOUN
admet-373	606	317	acidic	acidic	ADJ
admet-373	606	318	glipizide	glipizide	ADJ
admet-373	606	319	test	test	NOUN
admet-373	606	320	95.8	95.8	NUM
admet-373	606	321	3.54	3.54	NUM
admet-373	606	322	1.83	1.83	NUM
admet-373	606	323	12	12	NUM
admet-373	606	324	0.88	0.88	NUM
admet-373	606	325	-0.63	-0.63	NOUN
admet-373	606	326	acidic	acidic	ADJ
admet-373	606	327	granisetron	granisetron	ADJ
admet-373	606	328	hydrochloride	hydrochloride	NOUN
admet-373	606	329	test	test	NOUN
admet-373	606	330	69	69	NUM
admet-373	606	331	1.40	1.40	NUM
admet-373	606	332	4.34	4.34	NUM
admet-373	606	333	3.57	3.57	NUM
admet-373	606	334	1.47	1.47	NUM
admet-373	606	335	0.94	0.94	NUM
admet-373	606	336	basic	basic	ADJ
admet-373	606	337	guanabenz	guanabenz	PROPN
admet-373	606	338	acetate	acetate	PROPN
admet-373	606	339	test	test	NOUN
admet-373	606	340	88.1	88.1	NUM
admet-373	606	341	2.30	2.30	NUM
admet-373	606	342	4.85	4.85	NUM
admet-373	606	343	1.36	1.36	NUM
admet-373	606	344	1.90	1.90	NUM
admet-373	606	345	0.97	0.97	NUM
admet-373	606	346	basic	basic	ADJ
admet-373	606	347	haloperidol	haloperidol	NOUN
admet-373	606	348	test	test	NOUN
admet-373	606	349	90.4	90.4	NUM
admet-373	606	350	2.54	2.54	NUM
admet-373	606	351	4.6	4.6	NUM
admet-373	606	352	1.46	1.46	NUM
admet-373	606	353	1.84	1.84	NUM
admet-373	606	354	0.81	0.81	NUM
admet-373	606	355	basic	basic	ADJ
admet-373	606	356	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-373	606	357	test	test	NOUN
admet-373	606	358	45.4	45.4	NUM
admet-373	606	359	0.92	0.92	NUM
admet-373	606	360	1.62	1.62	NUM
admet-373	606	361	63.3	63.3	NUM
admet-373	606	362	0.19	0.19	NUM
admet-373	606	363	-0.15	-0.15	NUM
admet-373	606	364	imipramine	imipramine	PROPN
admet-373	606	365	hydrochloride	hydrochloride	NOUN
admet-373	606	366	test	test	NOUN
admet-373	606	367	86.3	86.3	NUM
admet-373	606	368	2.16	2.16	NUM
admet-373	606	369	4.23	4.23	NUM
admet-373	606	370	2.63	2.63	NUM
admet-373	606	371	1.59	1.59	NUM
admet-373	606	372	0.73	0.73	NUM
admet-373	606	373	basic	basic	ADJ
admet-373	606	374	indapamide	indapamide	NOUN
admet-373	606	375	test	test	NOUN
admet-373	606	376	75.1	75.1	NUM
admet-373	606	377	1.59	1.59	NUM
admet-373	606	378	2.6	2.6	NUM
admet-373	606	379	17.1	17.1	NUM
admet-373	606	380	0.76	0.76	NUM
admet-373	606	381	0.13	0.13	NUM
admet-373	606	382	weak	weak	ADJ
admet-373	606	383	acid	acid	NOUN
admet-373	606	384	indometacin	indometacin	ADJ
admet-373	606	385	test	test	NOUN
admet-373	606	386	98.6	98.6	NUM
admet-373	606	387	5.02	5.02	NUM
admet-373	606	388	2.34	2.34	NUM
admet-373	606	389	3.33	3.33	NUM
admet-373	606	390	1.44	1.44	NUM
admet-373	606	391	-0.74	-0.74	ADJ
admet-373	606	392	acidic	acidic	ADJ
admet-373	606	393	irbesartan	irbesartan	ADJ
admet-373	606	394	test	test	NOUN
admet-373	606	395	96.1	96.1	NUM
admet-373	606	396	3.64	3.64	NUM
admet-373	606	397	2.17	2.17	NUM
admet-373	606	398	8.18	8.18	NUM
admet-373	606	399	1.05	1.05	NUM
admet-373	606	400	-0.51	-0.51	NOUN
admet-373	606	401	acidic	acidic	ADJ
admet-373	606	402	isradipine	isradipine	PROPN
admet-373	606	403	test	test	NOUN
admet-373	606	404	94.4	94.4	NUM
admet-373	606	405	3.18	3.18	NUM
admet-373	606	406	3.48	3.48	NUM
admet-373	606	407	3.05	3.05	NUM
admet-373	606	408	1.51	1.51	NUM
admet-373	606	409	0.17	0.17	NUM
admet-373	606	410	neutral	neutral	ADJ
admet-373	606	411	ketoconazole	ketoconazole	NOUN
admet-373	606	412	training	train	VERB
admet-373	606	413	94.6	94.6	NUM
admet-373	606	414	3.22	3.22	NUM
admet-373	606	415	3.59	3.59	NUM
admet-373	606	416	2.69	2.69	NUM
admet-373	607	1	1.56	1.56	NUM
admet-373	607	2	0.21	0.21	NUM
admet-373	607	3	weak	weak	ADJ
admet-373	607	4	base	base	NOUN
admet-373	607	5	ketoprofen	ketoprofen	NOUN
admet-373	607	6	test	test	NOUN
admet-373	607	7	98.4	98.4	NUM
admet-373	607	8	4.85	4.85	NUM
admet-373	607	9	2.18	2.18	NUM
admet-373	607	10	4.3	4.3	NUM
admet-373	607	11	1.33	1.33	NUM
admet-373	607	12	-0.77	-0.77	NUM
admet-373	607	13	acidic	acidic	ADJ
admet-373	607	14	lamotrigine	lamotrigine	PROPN
admet-373	607	15	test	test	NOUN
admet-373	607	16	59.5	59.5	NUM
admet-373	607	17	1.17	1.17	NUM
admet-373	607	18	1.99	1.99	NUM
admet-373	607	19	38.5	38.5	NUM
admet-373	607	20	0.40	0.40	NUM
admet-373	607	21	-0.04	-0.04	NUM
admet-373	607	22	weak	weak	ADJ
admet-373	607	23	base	base	NOUN
admet-373	607	24	lansoprazole	lansoprazole	NOUN
admet-373	607	25	test	test	NOUN
admet-373	608	1	90.5	90.5	NUM
admet-373	608	2	2.55	2.55	NUM
admet-373	608	3	2.66	2.66	NUM
admet-373	608	4	9.45	9.45	NUM
admet-373	608	5	1.01	1.01	NUM
admet-373	608	6	-0.05	-0.05	NUM
admet-373	608	7	leflunomide	leflunomide	ADJ
admet-373	608	8	test	test	NOUN
admet-373	608	9	92.6	92.6	NUM
admet-373	608	10	2.84	2.84	NUM
admet-373	608	11	3.37	3.37	NUM
admet-373	608	12	4.07	4.07	NUM
admet-373	608	13	1.38	1.38	NUM
admet-373	608	14	0.20	0.20	NUM
admet-373	608	15	neutral	neutral	ADJ
admet-373	608	16	letrozole	letrozole	NOUN
admet-373	608	17	test	test	NOUN
admet-373	608	18	59.3	59.3	NUM
admet-373	608	19	1.17	1.17	NUM
admet-373	608	20	2.42	2.42	NUM
admet-373	608	21	25.7	25.7	NUM
admet-373	608	22	0.59	0.59	NUM
admet-373	608	23	0.15	0.15	NUM
admet-373	608	24	neutral	neutral	ADJ
admet-373	608	25	lorazepam	lorazepam	PROPN
admet-373	608	26	test	test	NOUN
admet-373	608	27	91.1	91.1	NUM
admet-373	608	28	2.62	2.62	NUM
admet-373	608	29	3.16	3.16	NUM
admet-373	608	30	5.67	5.67	NUM
admet-373	608	31	1.24	1.24	NUM
admet-373	608	32	0.15	0.15	NUM
admet-373	608	33	neutral	neutral	ADJ
admet-373	608	34	lovastatin	lovastatin	PROPN
admet-373	608	35	test	test	NOUN
admet-373	608	36	95.5	95.5	NUM
admet-373	608	37	3.45	3.45	NUM
admet-373	608	38	4.09	4.09	NUM
admet-373	608	39	1.47	1.47	NUM
admet-373	608	40	1.83	1.83	NUM
admet-373	608	41	0.38	0.38	NUM
admet-373	608	42	neutral	neutral	ADJ
admet-373	608	43	loxapine	loxapine	NOUN
admet-373	608	44	succinate	succinate	PROPN
admet-373	608	45	test	test	NOUN
admet-373	608	46	92.7	92.7	NUM
admet-373	608	47	2.85	2.85	NUM
admet-373	608	48	5.28	5.28	NUM
admet-373	608	49	0.658	0.658	NUM
admet-373	608	50	2.21	2.21	NUM
admet-373	608	51	1.04	1.04	NUM
admet-373	608	52	basic	basic	ADJ
admet-373	608	53	maprotiline	maprotiline	ADJ
admet-373	608	54	hydrochloride	hydrochloride	NOUN
admet-373	608	55	training	training	NOUN
admet-373	608	56	86	86	NUM
admet-373	608	57	2.13	2.13	NUM
admet-373	608	58	6.7	6.7	NUM
admet-373	608	59	0.25	0.25	NUM
admet-373	608	60	2.65	2.65	NUM
admet-373	608	61	1.82	1.82	NUM
admet-373	608	62	basic	basic	ADJ
admet-373	608	63	mebendazole	mebendazole	NOUN
admet-373	608	64	test	test	NOUN
admet-373	608	65	92.9	92.9	NUM
admet-373	608	66	2.89	2.89	NUM
admet-373	608	67	3.07	3.07	NUM
admet-373	608	68	5.25	5.25	NUM
admet-373	608	69	1.26	1.26	NUM
admet-373	608	70	0.06	0.06	NUM
admet-373	608	71	weak	weak	ADJ
admet-373	608	72	base	base	NOUN
admet-373	608	73	mercaptopurine	mercaptopurine	NOUN
admet-373	608	74	test	test	VERB
admet-373	608	75	41.2	41.2	NUM
admet-373	608	76	0.85	0.85	NUM
admet-373	608	77	methylprednisolone	methylprednisolone	ADJ
admet-373	608	78	test	test	NOUN
admet-373	608	79	71.9	71.9	NUM
admet-373	608	80	1.48	1.48	NUM
admet-373	608	81	2.6	2.6	NUM
admet-373	608	82	18.2	18.2	NUM
admet-373	608	83	0.74	0.74	NUM
admet-373	608	84	0.16	0.16	NUM
admet-373	608	85	neutral	neutral	ADJ
admet-373	608	86	metoclopramide	metoclopramide	NOUN
admet-373	608	87	hydrochloride	hydrochloride	NOUN
admet-373	608	88	test	test	NOUN
admet-373	608	89	58.9	58.9	NUM
admet-373	608	90	1.16	1.16	NUM
admet-373	608	91	3.54	3.54	NUM
admet-373	608	92	8.87	8.87	NUM
admet-373	608	93	1.07	1.07	NUM
admet-373	608	94	0.64	0.64	NUM
admet-373	608	95	basic	basic	ADJ
admet-373	608	96	metolazone	metolazone	NOUN
admet-373	608	97	test	test	NOUN
admet-373	608	98	83.8	83.8	NUM
admet-373	608	99	1.99	1.99	NUM
admet-373	608	100	2.49	2.49	NUM
admet-373	608	101	15.2	15.2	NUM
admet-373	608	102	0.81	0.81	NUM
admet-373	608	103	0.00	0.00	NUM
admet-373	608	104	neutral	neutral	ADJ
admet-373	608	105	mianserin	mianserin	NOUN
admet-373	608	106	test	test	NOUN
admet-373	608	107	91.9	91.9	NUM
admet-373	608	108	2.73	2.73	NUM
admet-373	608	109	5.47	5.47	NUM
admet-373	608	110	0.595	0.595	NUM
admet-373	608	111	2.26	2.26	NUM
admet-373	608	112	1.15	1.15	NUM
admet-373	608	113	basic	basic	ADJ
admet-373	608	114	mibefradil	mibefradil	NOUN
admet-373	608	115	dihydrochloride	dihydrochloride	NOUN
admet-373	608	116	test	test	VERB
admet-373	608	117	93.6	93.6	NUM
admet-373	608	118	3.01	3.01	NUM
admet-373	608	119	6.3	6.3	NUM
admet-373	608	120	0.231	0.231	NUM
admet-373	608	121	2.68	2.68	NUM
admet-373	608	122	1.45	1.45	NUM
admet-373	608	123	basic	basic	ADJ
admet-373	608	124	mifepristone	mifepristone	NOUN
admet-373	608	125	test	test	NOUN
admet-373	608	126	95.5	95.5	NUM
admet-373	608	127	3.45	3.45	NUM
admet-373	608	128	4.2	4.2	NUM
admet-373	608	129	1.33	1.33	NUM
admet-373	608	130	1.88	1.88	NUM
admet-373	608	131	0.43	0.43	NUM
admet-373	608	132	admet	admet	NOUN
admet-373	608	133	&	&	CCONJ
admet-373	608	134	dmpk	dmpk	PROPN
admet-373	608	135	5(1	5(1	NUM
admet-373	608	136	)	)	PUNCT
admet-373	608	137	(	(	PUNCT
admet-373	608	138	2017	2017	NUM
admet-373	608	139	)	)	PUNCT
admet-373	608	140	14	14	NUM
admet-373	608	141	-	-	SYM
admet-373	608	142	38	38	NUM
admet-373	608	143	in	in	ADP
admet-373	608	144	vitro	vitro	X
admet-373	608	145	membrane	membrane	NOUN
admet-373	608	146	and	and	CCONJ
admet-373	608	147	protein	protein	NOUN
admet-373	608	148	binding	bind	VERB
admet-373	608	149	doi	doi	NOUN
admet-373	608	150	:	:	PUNCT
admet-373	608	151	10.5599	10.5599	NUM
admet-373	608	152	/	/	SYM
admet-373	608	153	admet.5.1.373	admet.5.1.373	ADP
admet-373	608	154	37	37	NUM
admet-373	608	155	mycophenolic	mycophenolic	ADJ
admet-373	608	156	acid	acid	NOUN
admet-373	608	157	test	test	NOUN
admet-373	608	158	95.5	95.5	NUM
admet-373	608	159	3.45	3.45	NUM
admet-373	608	160	1.83	1.83	NUM
admet-373	608	161	12.7	12.7	NUM
admet-373	608	162	0.86	0.86	NUM
admet-373	608	163	-0.61	-0.61	NOUN
admet-373	608	164	acidic	acidic	ADJ
admet-373	608	165	nadolol	nadolol	PROPN
admet-373	608	166	test	test	VERB
admet-373	608	167	39.7	39.7	NUM
admet-373	608	168	0.83	0.83	NUM
admet-373	608	169	1.76	1.76	NUM
admet-373	608	170	58.5	58.5	NUM
admet-373	608	171	0.23	0.23	NUM
admet-373	608	172	-0.07	-0.07	NUM
admet-373	608	173	naproxen	naproxen	PROPN
admet-373	608	174	test	test	NOUN
admet-373	609	1	99.9	99.9	NUM
admet-373	609	2	7.09	7.09	NUM
admet-373	609	3	1.96	1.96	NUM
admet-373	609	4	1.55	1.55	NUM
admet-373	609	5	1.75	1.75	NUM
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admet-373	609	7	acidic	acidic	ADJ
admet-373	609	8	neostigmine	neostigmine	NOUN
admet-373	609	9	bromide	bromide	NOUN
admet-373	609	10	test	test	NOUN
admet-373	609	11	87.6	87.6	NUM
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admet-373	609	13	1.68	1.68	NUM
admet-373	609	14	28.1	28.1	NUM
admet-373	609	15	0.52	0.52	NUM
admet-373	609	16	-0.42	-0.42	NUM
admet-373	609	17	basic	basic	ADJ
admet-373	609	18	nevirapine	nevirapine	ADJ
admet-373	609	19	test	test	NOUN
admet-373	609	20	54	54	NUM
admet-373	609	21	1.06	1.06	NUM
admet-373	609	22	1.89	1.89	NUM
admet-373	609	23	45	45	NUM
admet-373	609	24	0.34	0.34	NUM
admet-373	609	25	-0.06	-0.06	NUM
admet-373	609	26	neutral	neutral	ADJ
admet-373	609	27	nicardipine	nicardipine	NOUN
admet-373	609	28	hydrochloride	hydrochloride	NOUN
admet-373	609	29	test	test	NOUN
admet-373	609	30	95.8	95.8	NUM
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admet-373	609	32	4.23	4.23	NUM
admet-373	609	33	1.21	1.21	NUM
admet-373	609	34	1.91	1.91	NUM
admet-373	609	35	0.42	0.42	NUM
admet-373	609	36	weak	weak	ADJ
admet-373	609	37	base	base	NOUN
admet-373	609	38	nimesulide	nimesulide	NOUN
admet-373	609	39	test	test	NOUN
admet-373	609	40	98	98	NUM
admet-373	609	41	4.55	4.55	NUM
admet-373	609	42	2.32	2.32	NUM
admet-373	609	43	4.4	4.4	NUM
admet-373	609	44	1.32	1.32	NUM
admet-373	609	45	-0.64	-0.64	NUM
admet-373	609	46	acidic	acidic	ADJ
admet-373	609	47	nimodipine	nimodipine	ADJ
admet-373	609	48	test	test	NOUN
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admet-373	609	50	2.74	2.74	NUM
admet-373	609	51	3.09	3.09	NUM
admet-373	609	52	5.64	5.64	NUM
admet-373	609	53	1.24	1.24	NUM
admet-373	609	54	0.10	0.10	NUM
admet-373	609	55	neutral	neutral	ADJ
admet-373	609	56	nisoldipine	nisoldipine	NOUN
admet-373	609	57	test	test	NOUN
admet-373	609	58	91	91	NUM
admet-373	609	59	2.61	2.61	NUM
admet-373	609	60	3.16	3.16	NUM
admet-373	609	61	5.67	5.67	NUM
admet-373	609	62	1.24	1.24	NUM
admet-373	609	63	0.16	0.16	NUM
admet-373	609	64	neutral	neutral	ADJ
admet-373	609	65	nitrendipine	nitrendipine	ADJ
admet-373	609	66	test	test	NOUN
admet-373	609	67	93.9	93.9	NUM
admet-373	609	68	3.07	3.07	NUM
admet-373	609	69	3.59	3.59	NUM
admet-373	609	70	2.88	2.88	NUM
admet-373	609	71	1.53	1.53	NUM
admet-373	609	72	0.24	0.24	NUM
admet-373	609	73	neutral	neutral	ADJ
admet-373	609	74	nortriptyline	nortriptyline	NOUN
admet-373	609	75	hydrochloride	hydrochloride	NOUN
admet-373	609	76	training	train	VERB
admet-373	609	77	86.2	86.2	NUM
admet-373	609	78	2.15	2.15	NUM
admet-373	609	79	5.66	5.66	NUM
admet-373	609	80	0.673	0.673	NUM
admet-373	609	81	2.21	2.21	NUM
admet-373	609	82	1.36	1.36	NUM
admet-373	609	83	basic	basic	ADJ
admet-373	609	84	olanzapine	olanzapine	NOUN
admet-373	609	85	test	test	NOUN
admet-373	609	86	86.2	86.2	NUM
admet-373	609	87	2.15	2.15	NUM
admet-373	609	88	5.06	5.06	NUM
admet-373	609	89	1.2	1.2	NUM
admet-373	609	90	1.95	1.95	NUM
admet-373	609	91	1.09	1.09	NUM
admet-373	609	92	basic	basic	ADJ
admet-373	609	93	pentoxifylline	pentoxifylline	NOUN
admet-373	609	94	test	test	NOUN
admet-373	609	95	25.9	25.9	NUM
admet-373	609	96	0.63	0.63	NUM
admet-373	609	97	1.47	1.47	NUM
admet-373	609	98	85.5	85.5	NUM
admet-373	609	99	0.06	0.06	NUM
admet-373	609	100	-0.15	-0.15	NUM
admet-373	609	101	neutral	neutral	ADJ
admet-373	609	102	pergolide	pergolide	NOUN
admet-373	609	103	mesylate	mesylate	NOUN
admet-373	609	104	test	test	NOUN
admet-373	609	105	85.2	85.2	NUM
admet-373	609	106	2.08	2.08	NUM
admet-373	609	107	5.71	5.71	NUM
admet-373	609	108	0.672	0.672	NUM
admet-373	609	109	2.21	2.21	NUM
admet-373	609	110	1.40	1.40	NUM
admet-373	609	111	basic	basic	ADJ
admet-373	609	112	phenytoin	phenytoin	NOUN
admet-373	609	113	test	test	NOUN
admet-373	609	114	83.4	83.4	NUM
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admet-373	609	116	2.51	2.51	NUM
admet-373	609	117	15.1	15.1	NUM
admet-373	609	118	0.81	0.81	NUM
admet-373	609	119	0.01	0.01	NUM
admet-373	609	120	weak	weak	ADJ
admet-373	609	121	acid	acid	NOUN
admet-373	609	122	pimozide	pimozide	ADJ
admet-373	609	123	test	test	NOUN
admet-373	609	124	98.6	98.6	NUM
admet-373	609	125	5.02	5.02	NUM
admet-373	609	126	5.61	5.61	NUM
admet-373	609	127	0.142	0.142	NUM
admet-373	609	128	2.85	2.85	NUM
admet-373	609	129	0.70	0.70	NUM
admet-373	609	130	basic	basic	ADJ
admet-373	609	131	pioglitazone	pioglitazone	NOUN
admet-373	609	132	hydrochloride	hydrochloride	NOUN
admet-373	609	133	test	test	NOUN
admet-373	609	134	97.9	97.9	NUM
admet-373	609	135	4.48	4.48	NUM
admet-373	609	136	2.76	2.76	NUM
admet-373	609	137	2.97	2.97	NUM
admet-373	609	138	1.50	1.50	NUM
admet-373	609	139	-0.43	-0.43	NUM
admet-373	609	140	piroxicam	piroxicam	PROPN
admet-373	609	141	test	test	NOUN
admet-373	609	142	97.3	97.3	NUM
admet-373	609	143	4.14	4.14	NUM
admet-373	609	144	1.9	1.9	NUM
admet-373	609	145	8.14	8.14	NUM
admet-373	609	146	1.05	1.05	NUM
admet-373	609	147	-0.73	-0.73	ADP
admet-373	609	148	acidic	acidic	ADJ
admet-373	609	149	pravastatin	pravastatin	NOUN
admet-373	609	150	sodium	sodium	NOUN
admet-373	609	151	test	test	NOUN
admet-373	609	152	40.3	40.3	NUM
admet-373	609	153	0.84	0.84	NUM
admet-373	609	154	1.83	1.83	NUM
admet-373	609	155	54	54	NUM
admet-373	609	156	0.26	0.26	NUM
admet-373	609	157	-0.04	-0.04	NUM
admet-373	609	158	acidic	acidic	ADJ
admet-373	609	159	prazosin	prazosin	NOUN
admet-373	609	160	hydrochloride	hydrochloride	NOUN
admet-373	609	161	test	test	NOUN
admet-373	609	162	85.2	85.2	NUM
admet-373	609	163	2.08	2.08	NUM
admet-373	609	164	2.47	2.47	NUM
admet-373	609	165	14.6	14.6	NUM
admet-373	609	166	0.82	0.82	NUM
admet-373	609	167	-0.03	-0.03	NUM
admet-373	609	168	weak	weak	ADJ
admet-373	609	169	base	base	NOUN
admet-373	609	170	primaquine	primaquine	NOUN
admet-373	609	171	phosphate	phosphate	NOUN
admet-373	609	172	test	test	NOUN
admet-373	609	173	79.2	79.2	NUM
admet-373	609	174	1.75	1.75	NUM
admet-373	609	175	4.6	4.6	NUM
admet-373	609	176	2.31	2.31	NUM
admet-373	609	177	1.66	1.66	NUM
admet-373	609	178	0.98	0.98	NUM
admet-373	609	179	basic	basic	ADJ
admet-373	609	180	probenecid	probenecid	NOUN
admet-373	609	181	training	train	VERB
admet-373	609	182	95.4	95.4	NUM
admet-373	609	183	3.43	3.43	NUM
admet-373	609	184	1.81	1.81	NUM
admet-373	609	185	13.2	13.2	NUM
admet-373	609	186	0.85	0.85	NUM
admet-373	609	187	-0.62	-0.62	NUM
admet-373	609	188	acidic	acidic	ADJ
admet-373	609	189	prochlorperazine	prochlorperazine	NOUN
admet-373	609	190	maleate	maleate	NOUN
admet-373	609	191	test	test	NOUN
admet-373	609	192	96.9	96.9	NUM
admet-373	609	193	3.95	3.95	NUM
admet-373	609	194	7.67	7.67	NUM
admet-373	609	195	0.037	0.037	NUM
admet-373	609	196	3.49	3.49	NUM
admet-373	609	197	1.85	1.85	NUM
admet-373	609	198	basic	basic	ADJ
admet-373	609	199	procyclidine	procyclidine	NOUN
admet-373	609	200	hydrochloride	hydrochloride	NOUN
admet-373	609	201	test	test	NOUN
admet-373	609	202	86.1	86.1	NUM
admet-373	609	203	2.14	2.14	NUM
admet-373	609	204	4.49	4.49	NUM
admet-373	609	205	1.72	1.72	NUM
admet-373	609	206	1.70	1.70	NUM
admet-373	609	207	0.84	0.84	NUM
admet-373	609	208	neutral	neutral	ADJ
admet-373	609	209	promethazine	promethazine	NOUN
admet-373	609	210	hydrochloride	hydrochloride	NOUN
admet-373	609	211	test	test	NOUN
admet-373	609	212	92.5	92.5	NUM
admet-373	609	213	2.82	2.82	NUM
admet-373	609	214	7.2	7.2	NUM
admet-373	609	215	0.107	0.107	NUM
admet-373	609	216	3.02	3.02	NUM
admet-373	609	217	1.89	1.89	NUM
admet-373	609	218	basic	basic	ADJ
admet-373	609	219	propafenone	propafenone	NOUN
admet-373	609	220	hydrochloride	hydrochloride	NOUN
admet-373	609	221	training	training	NOUN
admet-373	609	222	88	88	NUM
admet-373	609	223	2.29	2.29	NUM
admet-373	609	224	4.38	4.38	NUM
admet-373	609	225	2.1	2.1	NUM
admet-373	609	226	1.69	1.69	NUM
admet-373	609	227	0.76	0.76	NUM
admet-373	609	228	basic	basic	ADJ
admet-373	609	229	propranolol	propranolol	NOUN
admet-373	609	230	hcl	hcl	PROPN
admet-373	609	231	test	test	NOUN
admet-373	609	232	72.7	72.7	NUM
admet-373	609	233	1.51	1.51	NUM
admet-373	609	234	4.45	4.45	NUM
admet-373	609	235	3.04	3.04	NUM
admet-373	609	236	1.54	1.54	NUM
admet-373	609	237	0.97	0.97	NUM
admet-373	609	238	basic	basic	ADJ
admet-373	609	239	protriptyline	protriptyline	NOUN
admet-373	609	240	hydrochloride	hydrochloride	NOUN
admet-373	609	241	test	test	NOUN
admet-373	609	242	83.8	83.8	NUM
admet-373	609	243	1.99	1.99	NUM
admet-373	609	244	5.42	5.42	NUM
admet-373	609	245	0.929	0.929	NUM
admet-373	609	246	2.07	2.07	NUM
admet-373	609	247	1.29	1.29	NUM
admet-373	609	248	basic	basic	ADJ
admet-373	609	249	quinine	quinine	ADJ
admet-373	609	250	sulfate	sulfate	NOUN
admet-373	609	251	test	test	NOUN
admet-373	609	252	78.1	78.1	NUM
admet-373	609	253	1.70	1.70	NUM
admet-373	609	254	5.19	5.19	NUM
admet-373	609	255	1.35	1.35	NUM
admet-373	609	256	1.90	1.90	NUM
admet-373	609	257	1.25	1.25	NUM
admet-373	609	258	basic	basic	ADJ
admet-373	609	259	riluzole	riluzole	NOUN
admet-373	609	260	test	test	NOUN
admet-373	609	261	94.2	94.2	NUM
admet-373	609	262	3.13	3.13	NUM
admet-373	609	263	3.29	3.29	NUM
admet-373	609	264	3.71	3.71	NUM
admet-373	609	265	1.41	1.41	NUM
admet-373	609	266	0.10	0.10	NUM
admet-373	609	267	weak	weak	ADJ
admet-373	609	268	base	base	NOUN
admet-373	609	269	roxithromycin	roxithromycin	NOUN
admet-373	609	270	test	test	VERB
admet-373	609	271	46.6	46.6	NUM
admet-373	609	272	0.93	0.93	NUM
admet-373	609	273	5.37	5.37	NUM
admet-373	609	274	1.88	1.88	NUM
admet-373	609	275	1.80	1.80	NUM
admet-373	609	276	1.50	1.50	NUM
admet-373	610	1	saquinavir	saquinavir	NOUN
admet-373	611	1	test	test	VERB
admet-373	611	2	95.2	95.2	NUM
admet-373	611	3	3.37	3.37	NUM
admet-373	611	4	3.77	3.77	NUM
admet-373	611	5	2.07	2.07	NUM
admet-373	611	6	1.68	1.68	NUM
admet-373	611	7	0.26	0.26	NUM
admet-373	611	8	weak	weak	ADJ
admet-373	611	9	base	base	NOUN
admet-373	611	10	simvastatin	simvastatin	NOUN
admet-373	611	11	test	test	NOUN
admet-373	611	12	96.6	96.6	NUM
admet-373	611	13	3.82	3.82	NUM
admet-373	611	14	4.49	4.49	NUM
admet-373	611	15	0.823	0.823	NUM
admet-373	611	16	2.09	2.09	NUM
admet-373	611	17	0.47	0.47	NUM
admet-373	611	18	sulfinpyrazone	sulfinpyrazone	NOUN
admet-373	611	19	training	train	VERB
admet-373	611	20	97.2	97.2	NUM
admet-373	611	21	4.09	4.09	NUM
admet-373	611	22	2.11	2.11	NUM
admet-373	611	23	6.83	6.83	NUM
admet-373	611	24	1.13	1.13	NUM
admet-373	611	25	-0.63	-0.63	NUM
admet-373	611	26	acidic	acidic	ADJ
admet-373	611	27	sumatriptan	sumatriptan	ADJ
admet-373	611	28	test	test	NOUN
admet-373	611	29	28	28	NUM
admet-373	611	30	0.66	0.66	NUM
admet-373	611	31	2.68	2.68	NUM
admet-373	611	32	26.5	26.5	NUM
admet-373	611	33	0.58	0.58	NUM
admet-373	611	34	0.37	0.37	NUM
admet-373	611	35	basic	basic	ADJ
admet-373	611	36	valko	valko	NOUN
admet-373	611	37	,	,	PUNCT
admet-373	611	38	teague	teague	NOUN
admet-373	611	39	and	and	CCONJ
admet-373	611	40	pidgeon	pidgeon	PROPN
admet-373	611	41	admet	admet	PROPN
admet-373	611	42	&	&	CCONJ
admet-373	611	43	dmpk	dmpk	PROPN
admet-373	611	44	5(1	5(1	NUM
admet-373	611	45	)	)	PUNCT
admet-373	611	46	(	(	PUNCT
admet-373	611	47	2017	2017	NUM
admet-373	611	48	)	)	PUNCT
admet-373	611	49	14	14	NUM
admet-373	611	50	-	-	SYM
admet-373	611	51	38	38	NUM
admet-373	611	52	38	38	NUM
admet-373	611	53	tamsulosin	tamsulosin	NOUN
admet-373	611	54	hydrochloride	hydrochloride	NOUN
admet-373	611	55	test	test	NOUN
admet-373	611	56	68.9	68.9	NUM
admet-373	611	57	1.39	1.39	NUM
admet-373	611	58	2.84	2.84	NUM
admet-373	611	59	14.8	14.8	NUM
admet-373	611	60	0.82	0.82	NUM
admet-373	611	61	0.28	0.28	NUM
admet-373	611	62	basic	basic	ADJ
admet-373	611	63	trazodone	trazodone	NOUN
admet-373	611	64	hydrochloride	hydrochloride	NOUN
admet-373	611	65	test	test	NOUN
admet-373	611	66	92	92	NUM
admet-373	611	67	2.74	2.74	NUM
admet-373	611	68	3.04	3.04	NUM
admet-373	611	69	5.81	5.81	NUM
admet-373	611	70	1.22	1.22	NUM
admet-373	611	71	0.07	0.07	NUM
admet-373	611	72	weak	weak	ADJ
admet-373	611	73	base	base	NOUN
admet-373	611	74	venlafaxine	venlafaxine	ADJ
admet-373	611	75	hydrochloride	hydrochloride	NOUN
admet-373	611	76	test	test	NOUN
admet-373	611	77	35	35	NUM
admet-373	611	78	0.76	0.76	NUM
admet-373	611	79	3.19	3.19	NUM
admet-373	611	80	15.5	15.5	NUM
admet-373	611	81	0.83	0.83	NUM
admet-373	611	82	0.58	0.58	NUM
admet-373	611	83	basic	basic	ADJ
admet-373	611	84	verapamil	verapamil	NOUN
admet-373	611	85	hydrochloride	hydrochloride	NOUN
admet-373	611	86	test	test	NOUN
admet-373	611	87	88.1	88.1	NUM
admet-373	611	88	2.30	2.30	NUM
admet-373	611	89	3.59	3.59	NUM
admet-373	611	90	3.93	3.93	NUM
admet-373	611	91	1.35	1.35	NUM
admet-373	611	92	0.41	0.41	NUM
admet-373	611	93	basic	basic	ADJ
admet-373	611	94	zafirlukast	zafirlukast	NOUN
admet-373	611	95	test	test	NOUN
admet-373	611	96	99.1	99.1	NUM
admet-373	611	97	5.57	5.57	NUM
admet-373	611	98	3.67	3.67	NUM
admet-373	611	99	0.789	0.789	NUM
admet-373	611	100	2.14	2.14	NUM
admet-373	611	101	-0.27	-0.27	PROPN
admet-373	611	102	acidic	acidic	PROPN
admet-373	611	103	zalcitabine	zalcitabine	PROPN
admet-373	611	104	test	test	VERB
admet-373	611	105	23.6	23.6	NUM
admet-373	611	106	0.60	0.60	NUM
admet-373	611	107	zwitterionic	zwitterionic	ADJ
admet-373	611	108	zidovudine	zidovudine	PROPN
admet-373	611	109	test	test	VERB
admet-373	611	110	11.9	11.9	NUM
admet-373	611	111	0.42	0.42	NUM
admet-373	611	112	1.17	1.17	NUM
admet-373	611	113	127	127	NUM
admet-373	611	114	-0.12	-0.12	NUM
admet-373	611	115	-0.24	-0.24	ADJ
admet-373	611	116	weak	weak	ADJ
admet-373	611	117	acid	acid	NOUN
admet-373	611	118	zileuton	zileuton	NOUN
admet-373	611	119	training	training	NOUN
admet-373	611	120	89.7	89.7	NUM
admet-373	611	121	2.46	2.46	NUM
admet-373	611	122	2.53	2.53	NUM
admet-373	611	123	10.46	10.46	NUM
admet-373	611	124	0.93	0.93	NUM
admet-373	611	125	-0.09	-0.09	NUM
admet-373	611	126	neutral	neutral	ADJ
admet-373	611	127	ziprasidone	ziprasidone	NOUN
admet-373	611	128	hydrochloride	hydrochloride	NOUN
admet-373	611	129	training	train	VERB
admet-373	611	130	97.2	97.2	NUM
admet-373	611	131	4.09	4.09	NUM
admet-373	611	132	4.64	4.64	NUM
admet-373	611	133	0.596	0.596	NUM
admet-373	611	134	2.22	2.22	NUM
admet-373	611	135	0.48	0.48	NUM
admet-373	611	136	weak	weak	ADJ
admet-373	611	137	base	base	NOUN
admet-373	611	138	zolmitriptan	zolmitriptan	PROPN
admet-373	611	139	training	train	VERB
admet-373	611	140	61.4	61.4	NUM
admet-373	611	141	1.21	1.21	NUM
admet-373	611	142	2.78	2.78	NUM
admet-373	611	143	16.3	16.3	NUM
admet-373	611	144	0.75	0.75	NUM
admet-373	611	145	0.30	0.30	NUM
admet-373	611	146	basic	basic	ADJ
admet-373	611	147	©	©	PROPN
admet-373	611	148	2017	2017	NUM
admet-373	611	149	by	by	ADP
admet-373	611	150	the	the	DET
admet-373	611	151	authors	author	NOUN
admet-373	611	152	;	;	PUNCT
admet-373	611	153	licensee	licensee	PROPN
admet-373	611	154	iapc	iapc	PROPN
admet-373	611	155	,	,	PUNCT
admet-373	611	156	zagreb	zagreb	PROPN
admet-373	611	157	,	,	PUNCT
admet-373	611	158	croatia	croatia	PROPN
admet-373	611	159	.	.	PUNCT
admet-373	612	1	this	this	DET
admet-373	612	2	article	article	NOUN
admet-373	612	3	is	be	AUX
admet-373	612	4	an	an	DET
admet-373	612	5	open	open	ADJ
admet-373	612	6	-	-	PUNCT
admet-373	612	7	access	access	NOUN
admet-373	612	8	article	article	NOUN
admet-373	612	9	distributed	distribute	VERB
admet-373	612	10	under	under	ADP
admet-373	612	11	the	the	DET
admet-373	612	12	terms	term	NOUN
admet-373	612	13	and	and	CCONJ
admet-373	612	14	conditions	condition	NOUN
admet-373	612	15	of	of	ADP
admet-373	612	16	the	the	DET
admet-373	612	17	creative	creative	ADJ
admet-373	612	18	commons	common	NOUN
admet-373	612	19	attribution	attribution	NOUN
admet-373	612	20	license	license	NOUN
admet-373	612	21	(	(	PUNCT
admet-373	612	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-373	612	23	)	)	PUNCT
admet-373	612	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN