id	sid	tid	token	lemma	pos
admet-376	1	1	manuscript	manuscript	PROPN
admet-376	1	2	doi	doi	PROPN
admet-376	1	3	:	:	PUNCT
admet-376	1	4	10.5599	10.5599	NUM
admet-376	1	5	/	/	SYM
admet-376	1	6	admet.5.2.376	admet.5.2.376	PROPN
admet-376	1	7	85	85	NUM
admet-376	1	8	admet	admet	X
admet-376	1	9	&	&	CCONJ
admet-376	1	10	dmpk	dmpk	PROPN
admet-376	1	11	5(2	5(2	NUM
admet-376	1	12	)	)	PUNCT
admet-376	1	13	(	(	PUNCT
admet-376	1	14	2017	2017	NUM
admet-376	1	15	)	)	PUNCT
admet-376	1	16	85	85	NUM
admet-376	1	17	-	-	SYM
admet-376	1	18	125	125	NUM
admet-376	1	19	;	;	PUNCT
admet-376	1	20	doi	doi	NOUN
admet-376	1	21	:	:	PUNCT
admet-376	1	22	10.5599	10.5599	NUM
admet-376	1	23	/	/	SYM
admet-376	1	24	admet.5.2.376	admet.5.2.376	PROPN
admet-376	1	25	open	open	ADJ
admet-376	1	26	access	access	NOUN
admet-376	1	27	:	:	PUNCT
admet-376	1	28	issn	issn	PROPN
admet-376	1	29	:	:	PUNCT
admet-376	1	30	1848	1848	NUM
admet-376	1	31	-	-	SYM
admet-376	1	32	7718	7718	NUM
admet-376	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-376	1	34	original	original	ADJ
admet-376	1	35	scientific	scientific	ADJ
admet-376	1	36	paper	paper	NOUN
admet-376	1	37	consensus	consensus	NOUN
admet-376	1	38	rank	rank	NOUN
admet-376	1	39	orderings	ordering	NOUN
admet-376	1	40	of	of	ADP
admet-376	1	41	molecular	molecular	ADJ
admet-376	1	42	fingerprints	fingerprint	NOUN
admet-376	1	43	illustrate	illustrate	VERB
admet-376	1	44	the	the	DET
admet-376	1	45	‘	'	PUNCT
admet-376	1	46	most	most	ADV
admet-376	1	47	genuine	genuine	ADJ
admet-376	1	48	’	'	PUNCT
admet-376	1	49	similarities	similarity	NOUN
admet-376	1	50	between	between	ADP
admet-376	1	51	marketed	market	VERB
admet-376	1	52	drugs	drug	NOUN
admet-376	1	53	and	and	CCONJ
admet-376	1	54	small	small	ADJ
admet-376	1	55	endogenous	endogenous	ADJ
admet-376	1	56	human	human	ADJ
admet-376	1	57	metabolites	metabolite	NOUN
admet-376	1	58	,	,	PUNCT
admet-376	1	59	but	but	CCONJ
admet-376	1	60	highlight	highlight	VERB
admet-376	1	61	exogenous	exogenous	ADJ
admet-376	1	62	natural	natural	ADJ
admet-376	1	63	products	product	NOUN
admet-376	1	64	as	as	SCONJ
admet-376	1	65	the	the	DET
admet-376	1	66	most	most	ADV
admet-376	1	67	important	important	ADJ
admet-376	1	68	‘	'	PUNCT
admet-376	1	69	natural	natural	ADJ
admet-376	1	70	’	'	PUNCT
admet-376	1	71	drug	drug	NOUN
admet-376	1	72	transporter	transporter	NOUN
admet-376	1	73	substrates	substrate	VERB
admet-376	1	74	steve	steve	PROPN
admet-376	1	75	o’hagan1,2	o’hagan1,2	PROPN
admet-376	1	76	,	,	PUNCT
admet-376	1	77	douglas	douglas	PROPN
admet-376	1	78	b.	b.	PROPN
admet-376	1	79	kell1,2,3	kell1,2,3	PROPN
admet-376	1	80	,	,	PUNCT
admet-376	1	81	*	*	PROPN
admet-376	1	82	1	1	NUM
admet-376	1	83	school	school	NOUN
admet-376	1	84	of	of	ADP
admet-376	1	85	chemistry	chemistry	NOUN
admet-376	1	86	,	,	PUNCT
admet-376	1	87	2	2	NUM
admet-376	1	88	manchester	manchester	PROPN
admet-376	1	89	institute	institute	PROPN
admet-376	1	90	of	of	ADP
admet-376	1	91	biotechnology	biotechnology	NOUN
admet-376	1	92	,	,	PUNCT
admet-376	1	93	3	3	NUM
admet-376	1	94	centre	centre	NOUN
admet-376	1	95	for	for	ADP
admet-376	1	96	the	the	DET
admet-376	1	97	synthetic	synthetic	ADJ
admet-376	1	98	biology	biology	NOUN
admet-376	1	99	of	of	ADP
admet-376	1	100	fine	fine	ADJ
admet-376	1	101	and	and	CCONJ
admet-376	1	102	speciality	speciality	NOUN
admet-376	1	103	chemicals	chemical	NOUN
admet-376	1	104	(	(	PUNCT
admet-376	1	105	synbiochem	synbiochem	PROPN
admet-376	1	106	)	)	PUNCT
admet-376	1	107	,	,	PUNCT
admet-376	1	108	the	the	DET
admet-376	1	109	university	university	PROPN
admet-376	1	110	of	of	ADP
admet-376	1	111	manchester	manchester	PROPN
admet-376	1	112	,	,	PUNCT
admet-376	1	113	131	131	NUM
admet-376	1	114	princess	princess	PROPN
admet-376	1	115	st	st	PROPN
admet-376	1	116	,	,	PUNCT
admet-376	1	117	manchester	manchester	PROPN
admet-376	1	118	m1	m1	PROPN
admet-376	1	119	7dn	7dn	NOUN
admet-376	1	120	,	,	PUNCT
admet-376	1	121	uk	uk	PROPN
admet-376	1	122	*	*	PUNCT
admet-376	1	123	corresponding	correspond	VERB
admet-376	1	124	author	author	NOUN
admet-376	1	125	:	:	PUNCT
admet-376	1	126	e	e	NOUN
admet-376	1	127	-	-	NOUN
admet-376	1	128	mail	mail	NOUN
admet-376	1	129	:	:	PUNCT
admet-376	1	130	dbk@manchester.ac.uk	dbk@manchester.ac.uk	PROPN
admet-376	1	131	;	;	PUNCT
admet-376	1	132	tel	tel	PROPN
admet-376	1	133	.	.	PUNCT
admet-376	1	134	:	:	PUNCT
admet-376	2	1	+44	+44	PROPN
admet-376	2	2	-	-	PUNCT
admet-376	2	3	161	161	NUM
admet-376	2	4	-	-	PUNCT
admet-376	2	5	306	306	NUM
admet-376	2	6	-	-	SYM
admet-376	2	7	4492	4492	NUM
admet-376	2	8	http://dbkgroup.org/	http://dbkgroup.org/	PROPN
admet-376	2	9	@dbkell	@dbkell	PROPN
admet-376	2	10	received	receive	VERB
admet-376	2	11	:	:	PUNCT
admet-376	2	12	february	february	PROPN
admet-376	2	13	20	20	NUM
admet-376	2	14	,	,	PUNCT
admet-376	2	15	2017	2017	NUM
admet-376	2	16	;	;	PUNCT
admet-376	2	17	revised	revise	VERB
admet-376	2	18	:	:	PUNCT
admet-376	2	19	june	june	PROPN
admet-376	2	20	05	05	NUM
admet-376	2	21	,	,	PUNCT
admet-376	2	22	2017	2017	NUM
admet-376	2	23	;	;	PUNCT
admet-376	2	24	published	publish	VERB
admet-376	2	25	:	:	PUNCT
admet-376	2	26	june	june	PROPN
admet-376	2	27	22	22	NUM
admet-376	2	28	,	,	PUNCT
admet-376	2	29	2017	2017	NUM
admet-376	2	30	abstract	abstract	NOUN
admet-376	2	31	we	we	PRON
admet-376	2	32	compare	compare	VERB
admet-376	2	33	several	several	ADJ
admet-376	2	34	molecular	molecular	ADJ
admet-376	2	35	fingerprint	fingerprint	NOUN
admet-376	2	36	encodings	encoding	NOUN
admet-376	2	37	for	for	ADP
admet-376	2	38	marketed	market	VERB
admet-376	2	39	,	,	PUNCT
admet-376	2	40	small	small	ADJ
admet-376	2	41	molecule	molecule	NOUN
admet-376	2	42	drugs	drug	NOUN
admet-376	2	43	,	,	PUNCT
admet-376	2	44	and	and	CCONJ
admet-376	2	45	assess	assess	VERB
admet-376	2	46	how	how	SCONJ
admet-376	2	47	their	their	PRON
admet-376	2	48	rank	rank	NOUN
admet-376	2	49	order	order	NOUN
admet-376	2	50	varies	vary	VERB
admet-376	2	51	with	with	ADP
admet-376	2	52	the	the	DET
admet-376	2	53	fingerprint	fingerprint	NOUN
admet-376	2	54	in	in	ADP
admet-376	2	55	terms	term	NOUN
admet-376	2	56	of	of	ADP
admet-376	2	57	the	the	DET
admet-376	2	58	tanimoto	tanimoto	NOUN
admet-376	2	59	similarity	similarity	NOUN
admet-376	2	60	to	to	ADP
admet-376	2	61	the	the	DET
admet-376	2	62	most	most	ADV
admet-376	2	63	similar	similar	ADJ
admet-376	2	64	endogenous	endogenous	ADJ
admet-376	2	65	human	human	ADJ
admet-376	2	66	metabolite	metabolite	NOUN
admet-376	2	67	as	as	SCONJ
admet-376	2	68	taken	take	VERB
admet-376	2	69	from	from	ADP
admet-376	2	70	recon2	recon2	NOUN
admet-376	2	71	.	.	PUNCT
admet-376	3	1	for	for	ADP
admet-376	3	2	the	the	DET
admet-376	3	3	great	great	ADJ
admet-376	3	4	majority	majority	NOUN
admet-376	3	5	of	of	ADP
admet-376	3	6	drugs	drug	NOUN
admet-376	3	7	,	,	PUNCT
admet-376	3	8	the	the	DET
admet-376	3	9	rank	rank	NOUN
admet-376	3	10	order	order	NOUN
admet-376	3	11	varies	vary	VERB
admet-376	3	12	very	very	ADV
admet-376	3	13	greatly	greatly	ADV
admet-376	3	14	depending	depend	VERB
admet-376	3	15	on	on	ADP
admet-376	3	16	the	the	DET
admet-376	3	17	encoding	encoding	NOUN
admet-376	3	18	used	use	VERB
admet-376	3	19	,	,	PUNCT
admet-376	3	20	and	and	CCONJ
admet-376	3	21	also	also	ADV
admet-376	3	22	somewhat	somewhat	ADV
admet-376	3	23	when	when	SCONJ
admet-376	3	24	the	the	DET
admet-376	3	25	tanimoto	tanimoto	PROPN
admet-376	3	26	similarity	similarity	NOUN
admet-376	3	27	(	(	PUNCT
admet-376	3	28	ts	ts	NOUN
admet-376	3	29	)	)	PUNCT
admet-376	3	30	is	be	AUX
admet-376	3	31	replaced	replace	VERB
admet-376	3	32	by	by	ADP
admet-376	3	33	the	the	DET
admet-376	3	34	tversky	tversky	PROPN
admet-376	3	35	similarity	similarity	NOUN
admet-376	3	36	.	.	PUNCT
admet-376	4	1	however	however	ADV
admet-376	4	2	,	,	PUNCT
admet-376	4	3	for	for	ADP
admet-376	4	4	a	a	DET
admet-376	4	5	subset	subset	NOUN
admet-376	4	6	of	of	ADP
admet-376	4	7	such	such	ADJ
admet-376	4	8	drugs	drug	NOUN
admet-376	4	9	,	,	PUNCT
admet-376	4	10	amounting	amount	VERB
admet-376	4	11	to	to	ADP
admet-376	4	12	some	some	DET
admet-376	4	13	10	10	NUM
admet-376	4	14	%	%	NOUN
admet-376	4	15	of	of	ADP
admet-376	4	16	the	the	DET
admet-376	4	17	set	set	NOUN
admet-376	4	18	and	and	CCONJ
admet-376	4	19	a	a	DET
admet-376	4	20	tanimoto	tanimoto	NOUN
admet-376	4	21	similarity	similarity	NOUN
admet-376	4	22	of	of	ADP
admet-376	4	23	~0.8	~0.8	NOUN
admet-376	4	24	or	or	CCONJ
admet-376	4	25	greater	great	ADJ
admet-376	4	26	,	,	PUNCT
admet-376	4	27	the	the	DET
admet-376	4	28	similarity	similarity	NOUN
admet-376	4	29	coefficient	coefficient	NOUN
admet-376	4	30	is	be	AUX
admet-376	4	31	relatively	relatively	ADV
admet-376	4	32	robust	robust	ADJ
admet-376	4	33	to	to	ADP
admet-376	4	34	the	the	DET
admet-376	4	35	encoding	encoding	NOUN
admet-376	4	36	used	use	VERB
admet-376	4	37	.	.	PUNCT
admet-376	5	1	this	this	PRON
admet-376	5	2	leads	lead	VERB
admet-376	5	3	to	to	ADP
admet-376	5	4	a	a	DET
admet-376	5	5	metric	metric	NOUN
admet-376	5	6	that	that	PRON
admet-376	5	7	,	,	PUNCT
admet-376	5	8	while	while	SCONJ
admet-376	5	9	arbitrary	arbitrary	ADJ
admet-376	5	10	,	,	PUNCT
admet-376	5	11	suggests	suggest	VERB
admet-376	5	12	that	that	SCONJ
admet-376	5	13	a	a	DET
admet-376	5	14	tanimoto	tanimoto	NOUN
admet-376	5	15	similarity	similarity	NOUN
admet-376	5	16	of	of	ADP
admet-376	5	17	0.75	0.75	NUM
admet-376	5	18	-	-	SYM
admet-376	5	19	0.8	0.8	NUM
admet-376	5	20	or	or	CCONJ
admet-376	5	21	greater	great	ADJ
admet-376	5	22	genuinely	genuinely	ADV
admet-376	5	23	does	do	AUX
admet-376	5	24	imply	imply	VERB
admet-376	5	25	a	a	DET
admet-376	5	26	considerable	considerable	ADJ
admet-376	5	27	structural	structural	ADJ
admet-376	5	28	similarity	similarity	NOUN
admet-376	5	29	of	of	ADP
admet-376	5	30	two	two	NUM
admet-376	5	31	molecules	molecule	NOUN
admet-376	5	32	in	in	ADP
admet-376	5	33	the	the	DET
admet-376	5	34	drug	drug	NOUN
admet-376	5	35	-	-	PUNCT
admet-376	5	36	endogenite	endogenite	NOUN
admet-376	5	37	space	space	NOUN
admet-376	5	38	.	.	PUNCT
admet-376	6	1	although	although	SCONJ
admet-376	6	2	comparatively	comparatively	ADV
admet-376	6	3	few	few	ADJ
admet-376	6	4	(	(	PUNCT
admet-376	6	5	<	<	X
admet-376	6	6	10	10	NUM
admet-376	6	7	%	%	NOUN
admet-376	6	8	of	of	ADP
admet-376	6	9	)	)	PUNCT
admet-376	6	10	marketed	market	VERB
admet-376	6	11	drugs	drug	NOUN
admet-376	6	12	are	be	AUX
admet-376	6	13	,	,	PUNCT
admet-376	6	14	in	in	ADP
admet-376	6	15	this	this	DET
admet-376	6	16	sense	sense	NOUN
admet-376	6	17	,	,	PUNCT
admet-376	6	18	robustly	robustly	ADV
admet-376	6	19	similar	similar	ADJ
admet-376	6	20	to	to	ADP
admet-376	6	21	an	an	DET
admet-376	6	22	endogenite	endogenite	NOUN
admet-376	6	23	,	,	PUNCT
admet-376	6	24	there	there	PRON
admet-376	6	25	is	be	VERB
admet-376	6	26	often	often	ADV
admet-376	6	27	at	at	ADP
admet-376	6	28	least	least	ADJ
admet-376	6	29	one	one	NUM
admet-376	6	30	encoding	encoding	NOUN
admet-376	6	31	with	with	ADP
admet-376	6	32	which	which	PRON
admet-376	6	33	they	they	PRON
admet-376	6	34	are	be	AUX
admet-376	6	35	genuinely	genuinely	ADV
admet-376	6	36	similar	similar	ADJ
admet-376	6	37	(	(	PUNCT
admet-376	6	38	e.g.	e.g.	ADV
admet-376	6	39	ts	ts	X
admet-376	6	40	>	>	X
admet-376	6	41	0.75	0.75	NUM
admet-376	6	42	)	)	PUNCT
admet-376	6	43	.	.	PUNCT
admet-376	7	1	this	this	PRON
admet-376	7	2	is	be	AUX
admet-376	7	3	referred	refer	VERB
admet-376	7	4	to	to	ADP
admet-376	7	5	as	as	ADP
admet-376	7	6	the	the	DET
admet-376	7	7	take	take	NOUN
admet-376	7	8	your	your	PRON
admet-376	7	9	pick	pick	NOUN
admet-376	7	10	improved	improve	VERB
admet-376	7	11	cheminformatic	cheminformatic	ADJ
admet-376	7	12	analytical	analytical	ADJ
admet-376	7	13	likeness	likeness	NOUN
admet-376	7	14	or	or	CCONJ
admet-376	7	15	typical	typical	ADJ
admet-376	7	16	encoding	encoding	NOUN
admet-376	7	17	,	,	PUNCT
admet-376	7	18	and	and	CCONJ
admet-376	7	19	on	on	ADP
admet-376	7	20	this	this	DET
admet-376	7	21	basis	basis	NOUN
admet-376	7	22	some	some	DET
admet-376	7	23	66	66	NUM
admet-376	7	24	%	%	NOUN
admet-376	7	25	of	of	ADP
admet-376	7	26	drugs	drug	NOUN
admet-376	7	27	are	be	AUX
admet-376	7	28	within	within	ADP
admet-376	7	29	a	a	DET
admet-376	7	30	ts	ts	NOUN
admet-376	7	31	of	of	ADP
admet-376	7	32	0.75	0.75	NUM
admet-376	7	33	to	to	ADP
admet-376	7	34	an	an	DET
admet-376	7	35	endogenite	endogenite	NOUN
admet-376	7	36	.	.	PUNCT
admet-376	8	1	we	we	PRON
admet-376	8	2	next	next	VERB
admet-376	8	3	explicitly	explicitly	ADV
admet-376	8	4	recognise	recognise	VERB
admet-376	8	5	that	that	SCONJ
admet-376	8	6	natural	natural	ADJ
admet-376	8	7	evolution	evolution	NOUN
admet-376	8	8	will	will	AUX
admet-376	8	9	have	have	AUX
admet-376	8	10	selected	select	VERB
admet-376	8	11	for	for	ADP
admet-376	8	12	the	the	DET
admet-376	8	13	ability	ability	NOUN
admet-376	8	14	to	to	PART
admet-376	8	15	transport	transport	VERB
admet-376	8	16	dietary	dietary	ADJ
admet-376	8	17	substances	substance	NOUN
admet-376	8	18	,	,	PUNCT
admet-376	8	19	including	include	VERB
admet-376	8	20	plant	plant	NOUN
admet-376	8	21	,	,	PUNCT
admet-376	8	22	animal	animal	NOUN
admet-376	8	23	and	and	CCONJ
admet-376	8	24	microbial	microbial	ADJ
admet-376	8	25	‘	'	PUNCT
admet-376	8	26	secondary	secondary	ADJ
admet-376	8	27	’	'	PUNCT
admet-376	8	28	metabolites	metabolite	NOUN
admet-376	8	29	,	,	PUNCT
admet-376	8	30	that	that	PRON
admet-376	8	31	are	be	AUX
admet-376	8	32	of	of	ADP
admet-376	8	33	benefit	benefit	NOUN
admet-376	8	34	to	to	ADP
admet-376	8	35	the	the	DET
admet-376	8	36	host	host	NOUN
admet-376	8	37	.	.	PUNCT
admet-376	9	1	these	these	PRON
admet-376	9	2	should	should	AUX
admet-376	9	3	also	also	ADV
admet-376	9	4	be	be	AUX
admet-376	9	5	explored	explore	VERB
admet-376	9	6	in	in	ADP
admet-376	9	7	terms	term	NOUN
admet-376	9	8	of	of	ADP
admet-376	9	9	their	their	PRON
admet-376	9	10	closeness	closeness	NOUN
admet-376	9	11	to	to	ADP
admet-376	9	12	marketed	market	VERB
admet-376	9	13	drugs	drug	NOUN
admet-376	9	14	.	.	PUNCT
admet-376	10	1	we	we	PRON
admet-376	10	2	thus	thus	ADV
admet-376	10	3	compared	compare	VERB
admet-376	10	4	the	the	DET
admet-376	10	5	ts	ts	NOUN
admet-376	10	6	of	of	ADP
admet-376	10	7	marketed	market	VERB
admet-376	10	8	drugs	drug	NOUN
admet-376	10	9	with	with	ADP
admet-376	10	10	the	the	DET
admet-376	10	11	contents	content	NOUN
admet-376	10	12	of	of	ADP
admet-376	10	13	various	various	ADJ
admet-376	10	14	databases	database	NOUN
admet-376	10	15	of	of	ADP
admet-376	10	16	natural	natural	ADJ
admet-376	10	17	products	product	NOUN
admet-376	10	18	.	.	PUNCT
admet-376	11	1	when	when	SCONJ
admet-376	11	2	this	this	PRON
admet-376	11	3	is	be	AUX
admet-376	11	4	done	do	VERB
admet-376	11	5	,	,	PUNCT
admet-376	11	6	we	we	PRON
admet-376	11	7	find	find	VERB
admet-376	11	8	that	that	SCONJ
admet-376	11	9	some	some	DET
admet-376	11	10	80	80	NUM
admet-376	11	11	%	%	NOUN
admet-376	11	12	of	of	ADP
admet-376	11	13	marketed	market	VERB
admet-376	11	14	drugs	drug	NOUN
admet-376	11	15	are	be	AUX
admet-376	11	16	within	within	ADP
admet-376	11	17	a	a	DET
admet-376	11	18	ts	ts	NOUN
admet-376	11	19	of	of	ADP
admet-376	11	20	0.7	0.7	NUM
admet-376	11	21	to	to	ADP
admet-376	11	22	a	a	DET
admet-376	11	23	natural	natural	ADJ
admet-376	11	24	product	product	NOUN
admet-376	11	25	,	,	PUNCT
admet-376	11	26	even	even	ADV
admet-376	11	27	using	use	VERB
admet-376	11	28	just	just	ADV
admet-376	11	29	the	the	DET
admet-376	11	30	maccs	maccs	PROPN
admet-376	11	31	encoding	encoding	PROPN
admet-376	11	32	.	.	PUNCT
admet-376	12	1	for	for	ADP
admet-376	12	2	patterned	patterned	ADJ
admet-376	12	3	and	and	CCONJ
admet-376	12	4	typical	typical	ADJ
admet-376	12	5	encodings	encoding	NOUN
admet-376	12	6	,	,	PUNCT
admet-376	12	7	80	80	NUM
admet-376	12	8	%	%	NOUN
admet-376	12	9	and	and	CCONJ
admet-376	12	10	98	98	NUM
admet-376	12	11	%	%	NOUN
admet-376	12	12	of	of	ADP
admet-376	12	13	drugs	drug	NOUN
admet-376	12	14	are	be	AUX
admet-376	12	15	within	within	ADP
admet-376	12	16	a	a	DET
admet-376	12	17	ts	ts	NOUN
admet-376	12	18	of	of	ADP
admet-376	12	19	0.8	0.8	NUM
admet-376	12	20	to	to	PART
admet-376	12	21	(	(	PUNCT
admet-376	12	22	an	an	DET
admet-376	12	23	endogenite	endogenite	NOUN
admet-376	12	24	or	or	CCONJ
admet-376	12	25	)	)	PUNCT
admet-376	12	26	an	an	DET
admet-376	12	27	exogenous	exogenous	ADJ
admet-376	12	28	natural	natural	ADJ
admet-376	12	29	product	product	NOUN
admet-376	12	30	.	.	PUNCT
admet-376	13	1	this	this	PRON
admet-376	13	2	implies	imply	VERB
admet-376	13	3	strongly	strongly	ADV
admet-376	13	4	that	that	SCONJ
admet-376	13	5	it	it	PRON
admet-376	13	6	is	be	AUX
admet-376	13	7	these	these	DET
admet-376	13	8	exogeneous	exogeneous	ADJ
admet-376	13	9	(	(	PUNCT
admet-376	13	10	dietary	dietary	ADJ
admet-376	13	11	and	and	CCONJ
admet-376	13	12	medicinal	medicinal	ADJ
admet-376	13	13	)	)	PUNCT
admet-376	13	14	natural	natural	ADJ
admet-376	13	15	products	product	NOUN
admet-376	13	16	that	that	PRON
admet-376	13	17	are	be	AUX
admet-376	13	18	more	more	ADJ
admet-376	13	19	to	to	PART
admet-376	13	20	be	be	AUX
admet-376	13	21	seen	see	VERB
admet-376	13	22	as	as	ADP
admet-376	13	23	the	the	DET
admet-376	13	24	‘	'	PUNCT
admet-376	13	25	natural	natural	ADJ
admet-376	13	26	’	'	PUNCT
admet-376	13	27	substrates	substrate	NOUN
admet-376	13	28	of	of	ADP
admet-376	13	29	drug	drug	NOUN
admet-376	13	30	transporters	transporter	NOUN
admet-376	13	31	(	(	PUNCT
admet-376	13	32	as	as	SCONJ
admet-376	13	33	is	be	AUX
admet-376	13	34	recognised	recognise	VERB
admet-376	13	35	,	,	PUNCT
admet-376	13	36	for	for	ADP
admet-376	13	37	instance	instance	NOUN
admet-376	13	38	,	,	PUNCT
admet-376	13	39	for	for	ADP
admet-376	13	40	the	the	DET
admet-376	13	41	solute	solute	NOUN
admet-376	13	42	carrier	carrier	NOUN
admet-376	13	43	slc22a4	slc22a4	PROPN
admet-376	13	44	and	and	CCONJ
admet-376	13	45	ergothioneine	ergothioneine	NOUN
admet-376	13	46	)	)	PUNCT
admet-376	13	47	.	.	PUNCT
admet-376	14	1	this	this	DET
admet-376	14	2	novel	novel	ADJ
admet-376	14	3	analysis	analysis	NOUN
admet-376	14	4	casts	cast	VERB
admet-376	14	5	an	an	DET
admet-376	14	6	entirely	entirely	ADV
admet-376	14	7	different	different	ADJ
admet-376	14	8	light	light	NOUN
admet-376	14	9	on	on	ADP
admet-376	14	10	the	the	DET
admet-376	14	11	kinds	kind	NOUN
admet-376	14	12	of	of	ADP
admet-376	14	13	natural	natural	ADJ
admet-376	14	14	molecules	molecule	NOUN
admet-376	14	15	that	that	PRON
admet-376	14	16	are	be	AUX
admet-376	14	17	to	to	PART
admet-376	14	18	be	be	AUX
admet-376	14	19	seen	see	VERB
admet-376	14	20	as	as	ADV
admet-376	14	21	most	most	ADJ
admet-376	14	22	like	like	ADP
admet-376	14	23	marketed	market	VERB
admet-376	14	24	drugs	drug	NOUN
admet-376	14	25	,	,	PUNCT
admet-376	14	26	and	and	CCONJ
admet-376	14	27	hence	hence	ADV
admet-376	14	28	potential	potential	ADJ
admet-376	14	29	transporter	transporter	NOUN
admet-376	14	30	substrates	substrate	NOUN
admet-376	14	31	,	,	PUNCT
admet-376	14	32	and	and	CCONJ
admet-376	14	33	further	far	ADV
admet-376	14	34	suggests	suggest	VERB
admet-376	14	35	that	that	SCONJ
admet-376	14	36	a	a	DET
admet-376	14	37	renewed	renew	VERB
admet-376	14	38	exploitation	exploitation	NOUN
admet-376	14	39	of	of	ADP
admet-376	14	40	natural	natural	ADJ
admet-376	14	41	products	product	NOUN
admet-376	14	42	as	as	ADP
admet-376	14	43	drug	drug	NOUN
admet-376	14	44	scaffolds	scaffold	NOUN
admet-376	14	45	would	would	AUX
admet-376	14	46	be	be	AUX
admet-376	14	47	amply	amply	ADV
admet-376	14	48	rewarded	reward	VERB
admet-376	14	49	.	.	PUNCT
admet-376	15	1	keywords	keyword	VERB
admet-376	15	2	drug	drug	NOUN
admet-376	15	3	transporters	transporter	NOUN
admet-376	15	4	;	;	PUNCT
admet-376	15	5	cheminformatics	cheminformatic	NOUN
admet-376	15	6	;	;	PUNCT
admet-376	15	7	endogenites	endogenite	NOUN
admet-376	15	8	;	;	PUNCT
admet-376	15	9	metabolomics	metabolomic	NOUN
admet-376	15	10	;	;	PUNCT
admet-376	15	11	encodings	encoding	NOUN
admet-376	15	12	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-376	15	13	mailto:dbk@manchester.ac.uk	mailto:dbk@manchester.ac.uk	VERB
admet-376	15	14	http://dbkgroup.org/	http://dbkgroup.org/	PROPN
admet-376	15	15	o'hagan	o'hagan	PROPN
admet-376	15	16	&	&	CCONJ
admet-376	15	17	kell	kell	PROPN
admet-376	15	18	admet	admet	PROPN
admet-376	15	19	&	&	CCONJ
admet-376	15	20	dmpk	dmpk	PROPN
admet-376	15	21	5(2	5(2	NUM
admet-376	15	22	)	)	PUNCT
admet-376	15	23	(	(	PUNCT
admet-376	15	24	2017	2017	NUM
admet-376	15	25	)	)	PUNCT
admet-376	15	26	85	85	NUM
admet-376	15	27	-	-	SYM
admet-376	15	28	125	125	NUM
admet-376	15	29	86	86	NUM
admet-376	15	30	introduction	introduction	NOUN
admet-376	15	31	given	give	VERB
admet-376	15	32	the	the	DET
admet-376	15	33	overwhelming	overwhelming	ADJ
admet-376	15	34	evidence	evidence	NOUN
admet-376	15	35	[	[	X
admet-376	15	36	1	1	NUM
admet-376	15	37	-	-	SYM
admet-376	15	38	20	20	NUM
admet-376	15	39	]	]	PUNCT
admet-376	15	40	that	that	SCONJ
admet-376	15	41	pharmaceutical	pharmaceutical	ADJ
admet-376	15	42	drugs	drug	NOUN
admet-376	15	43	must	must	AUX
admet-376	15	44	and	and	CCONJ
admet-376	15	45	do	do	AUX
admet-376	15	46	exploit	exploit	VERB
admet-376	15	47	endogenous	endogenous	ADJ
admet-376	15	48	transporters	transporter	NOUN
admet-376	15	49	that	that	PRON
admet-376	15	50	normally	normally	ADV
admet-376	15	51	transport	transport	VERB
admet-376	15	52	biological	biological	ADJ
admet-376	15	53	metabolites	metabolite	NOUN
admet-376	15	54	,	,	PUNCT
admet-376	15	55	and	and	CCONJ
admet-376	15	56	that	that	SCONJ
admet-376	15	57	normally	normally	ADV
admet-376	15	58	any	any	DET
admet-376	15	59	diffusion	diffusion	NOUN
admet-376	15	60	of	of	ADP
admet-376	15	61	such	such	ADJ
admet-376	15	62	drugs	drug	NOUN
admet-376	15	63	through	through	ADP
admet-376	15	64	the	the	DET
admet-376	15	65	phospholipid	phospholipid	NOUN
admet-376	15	66	bilayer	bilayer	NOUN
admet-376	15	67	portions	portion	NOUN
admet-376	15	68	of	of	ADP
admet-376	15	69	undamaged	undamaged	ADJ
admet-376	15	70	biological	biological	ADJ
admet-376	15	71	membranes	membrane	NOUN
admet-376	15	72	is	be	AUX
admet-376	15	73	negligible	negligible	ADJ
admet-376	15	74	[	[	X
admet-376	15	75	1	1	NUM
admet-376	15	76	,	,	PUNCT
admet-376	15	77	3	3	NUM
admet-376	15	78	,	,	PUNCT
admet-376	15	79	5	5	NUM
admet-376	15	80	-	-	SYM
admet-376	15	81	7	7	NUM
admet-376	15	82	,	,	PUNCT
admet-376	15	83	10	10	NUM
admet-376	15	84	,	,	PUNCT
admet-376	15	85	11	11	NUM
admet-376	15	86	,	,	PUNCT
admet-376	15	87	13	13	NUM
admet-376	15	88	,	,	PUNCT
admet-376	15	89	21	21	NUM
admet-376	15	90	]	]	PUNCT
admet-376	15	91	,	,	PUNCT
admet-376	15	92	we	we	PRON
admet-376	15	93	[	[	X
admet-376	15	94	2	2	NUM
admet-376	15	95	,	,	PUNCT
admet-376	15	96	22	22	NUM
admet-376	15	97	-	-	SYM
admet-376	15	98	24	24	NUM
admet-376	15	99	]	]	PUNCT
admet-376	15	100	and	and	CCONJ
admet-376	15	101	others	other	NOUN
admet-376	15	102	(	(	PUNCT
admet-376	15	103	e.g.	e.g.	ADV
admet-376	15	104	[	[	X
admet-376	15	105	16	16	NUM
admet-376	15	106	,	,	PUNCT
admet-376	15	107	25	25	NUM
admet-376	15	108	-	-	SYM
admet-376	15	109	30	30	NUM
admet-376	15	110	]	]	PUNCT
admet-376	15	111	)	)	PUNCT
admet-376	15	112	have	have	AUX
admet-376	15	113	been	be	AUX
admet-376	15	114	assessing	assess	VERB
admet-376	15	115	the	the	DET
admet-376	15	116	extent	extent	NOUN
admet-376	15	117	to	to	PART
admet-376	15	118	which	which	PRON
admet-376	15	119	marketed	market	VERB
admet-376	15	120	(	(	PUNCT
admet-376	15	121	hence	hence	ADV
admet-376	15	122	successful	successful	ADJ
admet-376	15	123	)	)	PUNCT
admet-376	15	124	xenobiotic	xenobiotic	ADJ
admet-376	15	125	drugs	drug	NOUN
admet-376	15	126	are	be	AUX
admet-376	15	127	similar	similar	ADJ
admet-376	15	128	in	in	ADP
admet-376	15	129	structural	structural	ADJ
admet-376	15	130	terms	term	NOUN
admet-376	15	131	to	to	ADP
admet-376	15	132	endogenous	endogenous	ADJ
admet-376	15	133	human	human	ADJ
admet-376	15	134	metabolites	metabolite	NOUN
admet-376	15	135	(	(	PUNCT
admet-376	15	136	that	that	SCONJ
admet-376	15	137	we	we	PRON
admet-376	15	138	sometimes	sometimes	ADV
admet-376	15	139	refer	refer	VERB
admet-376	15	140	to	to	ADP
admet-376	15	141	as	as	ADP
admet-376	15	142	‘	'	PUNCT
admet-376	15	143	endogenites	endogenite	NOUN
admet-376	15	144	’	'	PUNCT
admet-376	15	145	)	)	PUNCT
admet-376	15	146	.	.	PUNCT
admet-376	16	1	chemical	chemical	NOUN
admet-376	16	2	similarity	similarity	NOUN
admet-376	16	3	is	be	AUX
admet-376	16	4	a	a	DET
admet-376	16	5	slippery	slippery	ADJ
admet-376	16	6	concept	concept	NOUN
admet-376	16	7	(	(	PUNCT
admet-376	16	8	see	see	VERB
admet-376	17	1	e.g.	e.g.	ADV
admet-376	17	2	[	[	X
admet-376	17	3	31	31	NUM
admet-376	17	4	-	-	SYM
admet-376	17	5	35	35	NUM
admet-376	17	6	]	]	PUNCT
admet-376	17	7	and	and	CCONJ
admet-376	17	8	below	below	ADV
admet-376	17	9	)	)	PUNCT
admet-376	17	10	but	but	CCONJ
admet-376	17	11	,	,	PUNCT
admet-376	17	12	leaving	leave	VERB
admet-376	17	13	aside	aside	ADV
admet-376	17	14	descriptor	descriptor	NOUN
admet-376	17	15	-	-	PUNCT
admet-376	17	16	based	base	VERB
admet-376	17	17	vectors	vector	NOUN
admet-376	17	18	[	[	X
admet-376	17	19	36	36	NUM
admet-376	17	20	]	]	PUNCT
admet-376	17	21	,	,	PUNCT
admet-376	17	22	it	it	PRON
admet-376	17	23	is	be	AUX
admet-376	17	24	most	most	ADV
admet-376	17	25	commonly	commonly	ADV
admet-376	17	26	assessed	assess	VERB
admet-376	17	27	by	by	ADP
admet-376	17	28	encoding	encode	VERB
admet-376	17	29	the	the	DET
admet-376	17	30	molecules	molecule	NOUN
admet-376	17	31	of	of	ADP
admet-376	17	32	interest	interest	NOUN
admet-376	17	33	into	into	ADP
admet-376	17	34	one	one	NUM
admet-376	17	35	or	or	CCONJ
admet-376	17	36	more	more	ADJ
admet-376	17	37	fingerprints	fingerprint	NOUN
admet-376	17	38	expressed	express	VERB
admet-376	17	39	as	as	ADP
admet-376	17	40	bitstrings	bitstring	NOUN
admet-376	17	41	,	,	PUNCT
admet-376	17	42	then	then	ADV
admet-376	17	43	comparing	compare	VERB
admet-376	17	44	the	the	DET
admet-376	17	45	bitstrings	bitstring	NOUN
admet-376	17	46	,	,	PUNCT
admet-376	17	47	again	again	ADV
admet-376	17	48	most	most	ADV
admet-376	17	49	commonly	commonly	ADV
admet-376	17	50	in	in	ADP
admet-376	17	51	terms	term	NOUN
admet-376	17	52	of	of	ADP
admet-376	17	53	their	their	PRON
admet-376	17	54	jaccard	jaccard	ADJ
admet-376	17	55	or	or	CCONJ
admet-376	17	56	tanimoto	tanimoto	NOUN
admet-376	17	57	similarity	similarity	NOUN
admet-376	17	58	[	[	X
admet-376	17	59	37	37	NUM
admet-376	17	60	-	-	SYM
admet-376	17	61	39	39	NUM
admet-376	17	62	]	]	PUNCT
admet-376	17	63	.	.	PUNCT
admet-376	18	1	our	our	PRON
admet-376	18	2	first	first	ADJ
admet-376	18	3	detailed	detailed	ADJ
admet-376	18	4	study	study	NOUN
admet-376	18	5	[	[	X
admet-376	18	6	22	22	NUM
admet-376	18	7	]	]	PUNCT
admet-376	18	8	noted	note	VERB
admet-376	18	9	that	that	SCONJ
admet-376	18	10	the	the	DET
admet-376	18	11	quantitative	quantitative	ADJ
admet-376	18	12	(	(	PUNCT
admet-376	18	13	jaccard	jaccard	PROPN
admet-376	18	14	/	/	SYM
admet-376	18	15	tanimoto	tanimoto	NOUN
admet-376	18	16	)	)	PUNCT
admet-376	18	17	similarity	similarity	NOUN
admet-376	18	18	varied	vary	VERB
admet-376	18	19	markedly	markedly	ADV
admet-376	18	20	with	with	ADP
admet-376	18	21	the	the	DET
admet-376	18	22	different	different	ADJ
admet-376	18	23	(	(	PUNCT
admet-376	18	24	fingerprint	fingerprint	NOUN
admet-376	18	25	-	-	PUNCT
admet-376	18	26	based	base	VERB
admet-376	18	27	)	)	PUNCT
admet-376	18	28	encodings	encoding	NOUN
admet-376	18	29	used	use	VERB
admet-376	18	30	(	(	PUNCT
admet-376	18	31	and	and	CCONJ
admet-376	18	32	we	we	PRON
admet-376	18	33	reproduce	reproduce	VERB
admet-376	18	34	the	the	DET
admet-376	18	35	essential	essential	ADJ
admet-376	18	36	and	and	CCONJ
admet-376	18	37	open	open	ADJ
admet-376	18	38	access	access	NOUN
admet-376	18	39	findings	finding	NOUN
admet-376	18	40	in	in	ADP
admet-376	18	41	figure	figure	NOUN
admet-376	18	42	1a	1a	NOUN
admet-376	18	43	,	,	PUNCT
admet-376	18	44	below	below	ADV
admet-376	18	45	)	)	PUNCT
admet-376	18	46	,	,	PUNCT
admet-376	18	47	just	just	ADV
admet-376	18	48	as	as	SCONJ
admet-376	18	49	does	do	VERB
admet-376	18	50	the	the	DET
admet-376	18	51	appearance	appearance	NOUN
admet-376	18	52	or	or	CCONJ
admet-376	18	53	otherwise	otherwise	ADV
admet-376	18	54	of	of	ADP
admet-376	18	55	‘	'	PUNCT
admet-376	18	56	activity	activity	NOUN
admet-376	18	57	cliffs	cliff	NOUN
admet-376	18	58	’	'	PUNCT
admet-376	19	1	[	[	X
admet-376	19	2	40	40	NUM
admet-376	19	3	-	-	SYM
admet-376	19	4	42	42	NUM
admet-376	19	5	]	]	PUNCT
admet-376	19	6	.	.	PUNCT
admet-376	20	1	to	to	ADP
admet-376	20	2	a	a	DET
admet-376	20	3	certain	certain	ADJ
admet-376	20	4	degree	degree	NOUN
admet-376	20	5	,	,	PUNCT
admet-376	20	6	the	the	DET
admet-376	20	7	shape	shape	NOUN
admet-376	20	8	of	of	ADP
admet-376	20	9	the	the	DET
admet-376	20	10	profiles	profile	NOUN
admet-376	20	11	of	of	ADP
admet-376	20	12	rank	rank	NOUN
admet-376	20	13	-	-	PUNCT
admet-376	20	14	ordered	order	VERB
admet-376	20	15	drugs	drug	NOUN
admet-376	20	16	vs	vs	ADP
admet-376	20	17	their	their	PRON
admet-376	20	18	tanimoto	tanimoto	NOUN
admet-376	20	19	similarity	similarity	NOUN
admet-376	20	20	to	to	ADP
admet-376	20	21	the	the	DET
admet-376	20	22	closest	close	ADJ
admet-376	20	23	endogenous	endogenous	ADJ
admet-376	20	24	metabolite	metabolite	NOUN
admet-376	20	25	were	be	AUX
admet-376	20	26	smooth	smooth	ADJ
admet-376	20	27	curves	curve	NOUN
admet-376	20	28	that	that	PRON
admet-376	20	29	differed	differ	VERB
admet-376	20	30	somewhat	somewhat	ADV
admet-376	20	31	.	.	PUNCT
admet-376	21	1	however	however	ADV
admet-376	21	2	,	,	PUNCT
admet-376	21	3	this	this	PRON
admet-376	21	4	of	of	ADP
admet-376	21	5	itself	itself	PRON
admet-376	21	6	did	do	AUX
admet-376	21	7	not	not	PART
admet-376	21	8	tell	tell	VERB
admet-376	21	9	us	we	PRON
admet-376	21	10	–	–	PUNCT
admet-376	21	11	notwithstanding	notwithstanding	ADP
admet-376	21	12	the	the	DET
admet-376	21	13	numerical	numerical	ADJ
admet-376	21	14	variation	variation	NOUN
admet-376	21	15	in	in	ADP
admet-376	21	16	tanimoto	tanimoto	NOUN
admet-376	21	17	similarity	similarity	NOUN
admet-376	21	18	with	with	ADP
admet-376	21	19	each	each	DET
admet-376	21	20	encoding	encoding	NOUN
admet-376	21	21	–	–	PUNCT
admet-376	21	22	whether	whether	SCONJ
admet-376	21	23	the	the	DET
admet-376	21	24	rank	rank	NOUN
admet-376	21	25	order	order	NOUN
admet-376	21	26	of	of	ADP
admet-376	21	27	individual	individual	ADJ
admet-376	21	28	drugs	drug	NOUN
admet-376	21	29	themselves	themselves	PRON
admet-376	21	30	was	be	AUX
admet-376	21	31	more	more	ADV
admet-376	21	32	or	or	CCONJ
admet-376	21	33	less	less	ADV
admet-376	21	34	well	well	ADV
admet-376	21	35	preserved	preserve	VERB
admet-376	21	36	for	for	ADP
admet-376	21	37	each	each	DET
admet-376	21	38	encoding	encoding	NOUN
admet-376	21	39	.	.	PUNCT
admet-376	22	1	in	in	ADP
admet-376	22	2	other	other	ADJ
admet-376	22	3	words	word	NOUN
admet-376	22	4	was	be	AUX
admet-376	22	5	the	the	DET
admet-376	22	6	drug	drug	NOUN
admet-376	22	7	that	that	PRON
admet-376	22	8	was	be	AUX
admet-376	22	9	numerically	numerically	ADV
admet-376	22	10	most	most	ADV
admet-376	22	11	similar	similar	ADJ
admet-376	22	12	to	to	ADP
admet-376	22	13	an	an	DET
admet-376	22	14	endogenite	endogenite	NOUN
admet-376	22	15	under	under	ADP
admet-376	22	16	the	the	DET
admet-376	22	17	maccs	maccs	PROPN
admet-376	22	18	encoding	encoding	NOUN
admet-376	22	19	also	also	ADV
admet-376	22	20	most	most	ADV
admet-376	22	21	similar	similar	ADJ
admet-376	22	22	under	under	ADV
admet-376	22	23	(	(	PUNCT
admet-376	22	24	say	say	INTJ
admet-376	22	25	)	)	PUNCT
admet-376	22	26	the	the	DET
admet-376	22	27	atom	atom	NOUN
admet-376	22	28	pair	pair	NOUN
admet-376	22	29	encoding	encoding	NOUN
admet-376	22	30	?	?	PUNCT
admet-376	23	1	the	the	DET
admet-376	23	2	tanimoto	tanimoto	PROPN
admet-376	23	3	similarity	similarity	NOUN
admet-376	23	4	is	be	AUX
admet-376	23	5	a	a	DET
admet-376	23	6	true	true	ADJ
admet-376	23	7	metric	metric	NOUN
admet-376	23	8	,	,	PUNCT
admet-376	23	9	and	and	CCONJ
admet-376	23	10	while	while	SCONJ
admet-376	23	11	it	it	PRON
admet-376	23	12	returns	return	VERB
admet-376	23	13	a	a	DET
admet-376	23	14	numerical	numerical	ADJ
admet-376	23	15	value	value	NOUN
admet-376	23	16	between	between	ADP
admet-376	23	17	0	0	NUM
admet-376	23	18	and	and	CCONJ
admet-376	23	19	1	1	NUM
admet-376	23	20	the	the	DET
admet-376	23	21	question	question	NOUN
admet-376	23	22	also	also	ADV
admet-376	23	23	arises	arise	VERB
admet-376	23	24	as	as	ADP
admet-376	23	25	to	to	ADP
admet-376	23	26	which	which	PRON
admet-376	23	27	values	value	NOUN
admet-376	23	28	of	of	ADP
admet-376	23	29	the	the	DET
admet-376	23	30	tanimoto	tanimoto	NOUN
admet-376	23	31	similarity	similarity	NOUN
admet-376	23	32	genuinely	genuinely	ADV
admet-376	23	33	count	count	VERB
admet-376	23	34	as	as	ADP
admet-376	23	35	‘	'	PUNCT
admet-376	23	36	significantly	significantly	ADV
admet-376	23	37	similar	similar	ADJ
admet-376	23	38	’	'	PUNCT
admet-376	24	1	[	[	X
admet-376	24	2	34	34	NUM
admet-376	24	3	]	]	PUNCT
admet-376	24	4	from	from	ADP
admet-376	24	5	a	a	DET
admet-376	24	6	utilitarian	utilitarian	ADJ
admet-376	24	7	point	point	NOUN
admet-376	24	8	of	of	ADP
admet-376	24	9	view	view	NOUN
admet-376	24	10	.	.	PUNCT
admet-376	25	1	unlike	unlike	ADP
admet-376	25	2	qsar	qsar	NOUN
admet-376	25	3	and	and	CCONJ
admet-376	25	4	other	other	ADJ
admet-376	25	5	‘	'	PUNCT
admet-376	25	6	supervised	supervised	ADJ
admet-376	25	7	’	'	PUNCT
admet-376	25	8	methods	method	NOUN
admet-376	25	9	where	where	SCONJ
admet-376	25	10	there	there	PRON
admet-376	25	11	is	be	VERB
admet-376	25	12	an	an	DET
admet-376	25	13	objective	objective	ADJ
admet-376	25	14	function	function	NOUN
admet-376	25	15	,	,	PUNCT
admet-376	25	16	for	for	ADP
admet-376	25	17	which	which	PRON
admet-376	25	18	the	the	DET
admet-376	25	19	predictions	prediction	NOUN
admet-376	25	20	of	of	ADP
admet-376	25	21	the	the	DET
admet-376	25	22	model	model	NOUN
admet-376	25	23	can	can	AUX
admet-376	25	24	be	be	AUX
admet-376	25	25	tested	test	VERB
admet-376	25	26	on	on	ADP
admet-376	25	27	unseen	unseen	ADJ
admet-376	25	28	data	datum	NOUN
admet-376	25	29	(	(	PUNCT
admet-376	25	30	e.g.	e.g.	ADV
admet-376	25	31	where	where	SCONJ
admet-376	25	32	a	a	DET
admet-376	25	33	tanimoto	tanimoto	NOUN
admet-376	25	34	similarity	similarity	NOUN
admet-376	25	35	of	of	ADP
admet-376	25	36	0.85	0.85	NUM
admet-376	25	37	to	to	ADP
admet-376	25	38	a	a	DET
admet-376	25	39	‘	'	PUNCT
admet-376	25	40	hit	hit	NOUN
admet-376	25	41	’	'	PUNCT
admet-376	25	42	in	in	ADP
admet-376	25	43	a	a	DET
admet-376	25	44	drug	drug	NOUN
admet-376	25	45	discovery	discovery	NOUN
admet-376	25	46	assay	assay	NOUN
admet-376	25	47	increases	increase	VERB
admet-376	25	48	the	the	DET
admet-376	25	49	chance	chance	NOUN
admet-376	25	50	of	of	ADP
admet-376	25	51	another	another	DET
admet-376	25	52	hit	hit	NOUN
admet-376	25	53	by	by	ADP
admet-376	25	54	30	30	NUM
admet-376	25	55	-	-	NOUN
admet-376	25	56	fold	fold	ADJ
admet-376	25	57	[	[	X
admet-376	25	58	43	43	NUM
admet-376	25	59	]	]	NUM
admet-376	25	60	)	)	PUNCT
admet-376	25	61	,	,	PUNCT
admet-376	25	62	the	the	DET
admet-376	25	63	pure	pure	ADJ
admet-376	25	64	notion	notion	NOUN
admet-376	25	65	of	of	ADP
admet-376	25	66	chemical	chemical	ADJ
admet-376	25	67	similarity	similarity	NOUN
admet-376	25	68	is	be	AUX
admet-376	25	69	really	really	ADV
admet-376	25	70	an	an	DET
admet-376	25	71	‘	'	PUNCT
admet-376	25	72	unsupervised	unsupervised	ADJ
admet-376	25	73	’	'	PUNCT
admet-376	25	74	method	method	NOUN
admet-376	25	75	,	,	PUNCT
admet-376	25	76	and	and	CCONJ
admet-376	25	77	its	its	PRON
admet-376	25	78	numerical	numerical	ADJ
admet-376	25	79	value	value	NOUN
admet-376	25	80	is	be	AUX
admet-376	25	81	simply	simply	ADV
admet-376	25	82	that	that	PRON
admet-376	25	83	.	.	PUNCT
admet-376	26	1	previously	previously	ADV
admet-376	26	2	,	,	PUNCT
admet-376	26	3	apart	apart	ADV
admet-376	26	4	from	from	ADP
admet-376	26	5	the	the	DET
admet-376	26	6	addition	addition	NOUN
admet-376	26	7	of	of	ADP
admet-376	26	8	vitamins	vitamin	NOUN
admet-376	26	9	,	,	PUNCT
admet-376	26	10	we	we	PRON
admet-376	26	11	were	be	AUX
admet-376	26	12	rather	rather	ADV
admet-376	26	13	restrictive	restrictive	ADJ
admet-376	26	14	about	about	ADP
admet-376	26	15	what	what	PRON
admet-376	26	16	might	might	AUX
admet-376	26	17	constitute	constitute	VERB
admet-376	26	18	an	an	DET
admet-376	26	19	endogenous	endogenous	ADJ
admet-376	26	20	metabolite	metabolite	NOUN
admet-376	26	21	or	or	CCONJ
admet-376	26	22	‘	'	PUNCT
admet-376	26	23	endogenite	endogenite	NOUN
admet-376	26	24	’	'	PUNCT
admet-376	26	25	,	,	PUNCT
admet-376	26	26	and	and	CCONJ
admet-376	26	27	we	we	PRON
admet-376	26	28	here	here	ADV
admet-376	26	29	recognise	recognise	VERB
admet-376	26	30	that	that	SCONJ
admet-376	26	31	this	this	DET
admet-376	26	32	restriction	restriction	NOUN
admet-376	26	33	was	be	AUX
admet-376	26	34	not	not	PART
admet-376	26	35	only	only	ADV
admet-376	26	36	unnecessary	unnecessary	ADJ
admet-376	26	37	but	but	CCONJ
admet-376	26	38	potentially	potentially	ADV
admet-376	26	39	very	very	ADV
admet-376	26	40	misleading	misleading	ADJ
admet-376	26	41	,	,	PUNCT
admet-376	26	42	as	as	ADP
admet-376	26	43	any	any	DET
admet-376	26	44	natural	natural	ADJ
admet-376	26	45	molecule	molecule	NOUN
admet-376	26	46	with	with	ADP
admet-376	26	47	a	a	DET
admet-376	26	48	high	high	ADJ
admet-376	26	49	kcat	kcat	NOUN
admet-376	26	50	or	or	CCONJ
admet-376	26	51	kcat	kcat	NOUN
admet-376	26	52	/	/	SYM
admet-376	26	53	km	km	NOUN
admet-376	27	1	[	[	PUNCT
admet-376	27	2	44	44	NUM
admet-376	27	3	-	-	SYM
admet-376	27	4	47	47	NUM
admet-376	27	5	]	]	PUNCT
admet-376	27	6	for	for	ADP
admet-376	27	7	a	a	DET
admet-376	27	8	particular	particular	ADJ
admet-376	27	9	transporter	transporter	NOUN
admet-376	27	10	might	might	AUX
admet-376	27	11	reasonably	reasonably	ADV
admet-376	27	12	be	be	AUX
admet-376	27	13	regarded	regard	VERB
admet-376	27	14	as	as	ADP
admet-376	27	15	a	a	DET
admet-376	27	16	‘	'	PUNCT
admet-376	27	17	natural	natural	ADJ
admet-376	27	18	’	'	PUNCT
admet-376	27	19	substrate	substrate	NOUN
admet-376	27	20	for	for	ADP
admet-376	27	21	it	it	PRON
admet-376	27	22	.	.	PUNCT
admet-376	28	1	in	in	ADP
admet-376	28	2	particular	particular	ADJ
admet-376	28	3	,	,	PUNCT
admet-376	28	4	we	we	PRON
admet-376	28	5	may	may	AUX
admet-376	28	6	suppose	suppose	VERB
admet-376	28	7	that	that	SCONJ
admet-376	28	8	there	there	PRON
admet-376	28	9	are	be	VERB
admet-376	28	10	or	or	CCONJ
admet-376	28	11	have	have	AUX
admet-376	28	12	been	be	AUX
admet-376	28	13	natural	natural	ADJ
admet-376	28	14	,	,	PUNCT
admet-376	28	15	bioactive	bioactive	ADJ
admet-376	28	16	/	/	SYM
admet-376	28	17	psychoactive	psychoactive	ADJ
admet-376	28	18	dietary	dietary	ADJ
admet-376	28	19	and	and	CCONJ
admet-376	28	20	medicinal	medicinal	ADJ
admet-376	28	21	components	component	NOUN
admet-376	28	22	(	(	PUNCT
admet-376	28	23	and	and	CCONJ
admet-376	28	24	their	their	PRON
admet-376	28	25	and	and	CCONJ
admet-376	28	26	other	other	ADJ
admet-376	28	27	microbiome	microbiome	NOUN
admet-376	28	28	-	-	PUNCT
admet-376	28	29	derived	derive	VERB
admet-376	28	30	products	product	NOUN
admet-376	28	31	)	)	PUNCT
admet-376	28	32	that	that	PRON
admet-376	28	33	are	be	AUX
admet-376	28	34	both	both	PRON
admet-376	28	35	beneficial	beneficial	ADJ
admet-376	28	36	and	and	CCONJ
admet-376	28	37	common	common	ADJ
admet-376	28	38	enough	enough	ADV
admet-376	28	39	that	that	SCONJ
admet-376	28	40	the	the	DET
admet-376	28	41	host	host	NOUN
admet-376	28	42	has	have	AUX
admet-376	28	43	essentially	essentially	ADV
admet-376	28	44	been	be	AUX
admet-376	28	45	exposed	expose	VERB
admet-376	28	46	to	to	ADP
admet-376	28	47	them	they	PRON
admet-376	28	48	more	more	ADV
admet-376	28	49	or	or	CCONJ
admet-376	28	50	less	less	ADV
admet-376	28	51	regularly	regularly	ADV
admet-376	28	52	through	through	ADP
admet-376	28	53	evolutionary	evolutionary	ADJ
admet-376	28	54	time	time	NOUN
admet-376	28	55	,	,	PUNCT
admet-376	28	56	albeit	albeit	SCONJ
admet-376	28	57	they	they	PRON
admet-376	28	58	do	do	AUX
admet-376	28	59	not	not	PART
admet-376	28	60	appear	appear	VERB
admet-376	28	61	in	in	ADP
admet-376	28	62	the	the	DET
admet-376	28	63	common	common	ADJ
admet-376	28	64	models	model	NOUN
admet-376	28	65	of	of	ADP
admet-376	28	66	human	human	ADJ
admet-376	28	67	metabolism	metabolism	NOUN
admet-376	28	68	.	.	PUNCT
admet-376	29	1	since	since	SCONJ
admet-376	29	2	useful	useful	ADJ
admet-376	29	3	bioactivity	bioactivity	NOUN
admet-376	29	4	in	in	ADP
admet-376	29	5	tissues	tissue	NOUN
admet-376	29	6	implies	imply	VERB
admet-376	29	7	uptake	uptake	ADJ
admet-376	29	8	,	,	PUNCT
admet-376	29	9	natural	natural	ADJ
admet-376	29	10	selection	selection	NOUN
admet-376	29	11	would	would	AUX
admet-376	29	12	then	then	ADV
admet-376	29	13	ensure	ensure	VERB
admet-376	29	14	that	that	SCONJ
admet-376	29	15	we	we	PRON
admet-376	29	16	had	have	AUX
admet-376	29	17	actually	actually	ADV
admet-376	29	18	evolved	evolve	VERB
admet-376	29	19	transporters	transporter	NOUN
admet-376	29	20	for	for	ADP
admet-376	29	21	them	they	PRON
admet-376	29	22	,	,	PUNCT
admet-376	29	23	and	and	CCONJ
admet-376	29	24	that	that	SCONJ
admet-376	29	25	these	these	DET
admet-376	29	26	molecules	molecule	NOUN
admet-376	29	27	,	,	PUNCT
admet-376	29	28	despite	despite	SCONJ
admet-376	29	29	not	not	PART
admet-376	29	30	being	be	AUX
admet-376	29	31	synthesised	synthesise	VERB
admet-376	29	32	by	by	ADP
admet-376	29	33	the	the	DET
admet-376	29	34	host	host	NOUN
admet-376	29	35	,	,	PUNCT
admet-376	29	36	are	be	AUX
admet-376	29	37	properly	properly	ADV
admet-376	29	38	to	to	PART
admet-376	29	39	be	be	AUX
admet-376	29	40	seen	see	VERB
admet-376	29	41	as	as	ADP
admet-376	29	42	‘	'	PUNCT
admet-376	29	43	natural	natural	ADJ
admet-376	29	44	substrates	substrate	NOUN
admet-376	29	45	’	'	PUNCT
admet-376	29	46	of	of	ADP
admet-376	29	47	such	such	ADJ
admet-376	29	48	transporters	transporter	NOUN
admet-376	29	49	.	.	PUNCT
admet-376	30	1	l	l	X
admet-376	30	2	-	-	PUNCT
admet-376	30	3	ergothioneine	ergothioneine	NOUN
admet-376	30	4	is	be	AUX
admet-376	30	5	a	a	DET
admet-376	30	6	particularly	particularly	ADV
admet-376	30	7	clear	clear	ADJ
admet-376	30	8	example	example	NOUN
admet-376	30	9	of	of	ADP
admet-376	30	10	this	this	PRON
admet-376	30	11	.	.	PUNCT
admet-376	31	1	some	some	DET
admet-376	31	2	mammalian	mammalian	ADJ
admet-376	31	3	transporters	transporter	NOUN
admet-376	31	4	with	with	ADP
admet-376	31	5	known	know	VERB
admet-376	31	6	selectivity	selectivity	NOUN
admet-376	31	7	for	for	ADP
admet-376	31	8	exogenous	exogenous	ADJ
admet-376	31	9	natural	natural	ADJ
admet-376	31	10	products	product	NOUN
admet-376	31	11	l	l	NOUN
admet-376	31	12	-	-	NOUN
admet-376	31	13	ergothioneine	ergothioneine	ADJ
admet-376	31	14	(	(	PUNCT
admet-376	31	15	2	2	NUM
admet-376	31	16	-	-	PUNCT
admet-376	31	17	mercaptohistidine	mercaptohistidine	NOUN
admet-376	31	18	trimethylbetaine	trimethylbetaine	NOUN
admet-376	31	19	;	;	PUNCT
admet-376	31	20	iupac	iupac	PROPN
admet-376	31	21	name	name	NOUN
admet-376	31	22	(	(	PUNCT
admet-376	31	23	2s)-3-(2	2s)-3-(2	NUM
admet-376	31	24	-	-	PUNCT
admet-376	31	25	thioxo-2,3	thioxo-2,3	NUM
admet-376	31	26	-	-	PUNCT
admet-376	31	27	dihydro-1himidazol-4	dihydro-1himidazol-4	NOUN
admet-376	31	28	-	-	PUNCT
admet-376	31	29	yl)-2-(trimethylammonio)propanoate	yl)-2-(trimethylammonio)propanoate	NOUN
admet-376	31	30	)	)	PUNCT
admet-376	31	31	is	be	AUX
admet-376	31	32	not	not	PART
admet-376	31	33	synthesised	synthesise	VERB
admet-376	31	34	by	by	ADP
admet-376	31	35	mammals	mammal	NOUN
admet-376	31	36	,	,	PUNCT
admet-376	31	37	but	but	CCONJ
admet-376	31	38	exists	exist	VERB
admet-376	31	39	in	in	ADP
admet-376	31	40	a	a	DET
admet-376	31	41	wide	wide	ADJ
admet-376	31	42	range	range	NOUN
admet-376	31	43	of	of	ADP
admet-376	31	44	foodstuffs	foodstuff	NOUN
admet-376	31	45	(	(	PUNCT
admet-376	31	46	especially	especially	ADV
admet-376	31	47	mushrooms	mushroom	NOUN
admet-376	31	48	)	)	PUNCT
admet-376	31	49	and	and	CCONJ
admet-376	31	50	may	may	AUX
admet-376	31	51	be	be	AUX
admet-376	31	52	highly	highly	ADV
admet-376	31	53	concentrated	concentrated	ADJ
admet-376	31	54	in	in	ADP
admet-376	31	55	mammalian	mammalian	ADJ
admet-376	31	56	tissues	tissue	NOUN
admet-376	32	1	[	[	X
admet-376	32	2	48	48	NUM
admet-376	32	3	,	,	PUNCT
admet-376	32	4	49	49	NUM
admet-376	32	5	]	]	PUNCT
admet-376	32	6	.	.	PUNCT
admet-376	33	1	several	several	ADJ
admet-376	33	2	types	type	NOUN
admet-376	33	3	of	of	ADP
admet-376	33	4	evidence	evidence	NOUN
admet-376	33	5	imply	imply	VERB
admet-376	33	6	that	that	SCONJ
admet-376	33	7	it	it	PRON
admet-376	33	8	has	have	VERB
admet-376	33	9	an	an	DET
admet-376	33	10	important	important	ADJ
admet-376	33	11	role	role	NOUN
admet-376	33	12	in	in	ADP
admet-376	33	13	vivo	vivo	NOUN
admet-376	33	14	as	as	ADP
admet-376	33	15	a	a	DET
admet-376	33	16	natural	natural	ADJ
admet-376	33	17	antioxidant	antioxidant	NOUN
admet-376	34	1	[	[	X
admet-376	34	2	50	50	NUM
admet-376	34	3	-	-	SYM
admet-376	34	4	52	52	NUM
admet-376	34	5	]	]	PUNCT
admet-376	34	6	.	.	PUNCT
admet-376	35	1	first	first	ADV
admet-376	35	2	this	this	DET
admet-376	35	3	activity	activity	NOUN
admet-376	35	4	may	may	AUX
admet-376	35	5	be	be	AUX
admet-376	35	6	measured	measure	VERB
admet-376	35	7	directly	directly	ADV
admet-376	35	8	[	[	X
admet-376	35	9	53	53	NUM
admet-376	35	10	-	-	SYM
admet-376	35	11	55	55	NUM
admet-376	35	12	]	]	PUNCT
admet-376	35	13	.	.	PUNCT
admet-376	36	1	secondly	secondly	ADV
admet-376	36	2	,	,	PUNCT
admet-376	36	3	decreasing	decrease	VERB
admet-376	36	4	it	it	PRON
admet-376	36	5	leads	lead	VERB
admet-376	36	6	to	to	ADP
admet-376	36	7	the	the	DET
admet-376	36	8	accumulation	accumulation	NOUN
admet-376	36	9	of	of	ADP
admet-376	36	10	the	the	DET
admet-376	36	11	admet	admet	PROPN
admet-376	36	12	&	&	CCONJ
admet-376	36	13	dmpk	dmpk	PROPN
admet-376	36	14	5(2	5(2	NUM
admet-376	36	15	)	)	PUNCT
admet-376	36	16	(	(	PUNCT
admet-376	36	17	2017	2017	NUM
admet-376	36	18	)	)	PUNCT
admet-376	36	19	85	85	NUM
admet-376	36	20	-	-	SYM
admet-376	36	21	125	125	NUM
admet-376	36	22	exogenous	exogenous	ADJ
admet-376	36	23	natural	natural	ADJ
admet-376	36	24	products	product	NOUN
admet-376	36	25	as	as	ADP
admet-376	36	26	‘	'	PUNCT
admet-376	36	27	natural	natural	ADJ
admet-376	36	28	’	'	PUNCT
admet-376	36	29	drug	drug	NOUN
admet-376	36	30	transporter	transporter	NOUN
admet-376	36	31	substrates	substrate	VERB
admet-376	36	32	doi	doi	NOUN
admet-376	36	33	:	:	PUNCT
admet-376	36	34	10.5599	10.5599	NUM
admet-376	36	35	/	/	SYM
admet-376	36	36	admet.5.2.376	admet.5.2.376	PROPN
admet-376	36	37	87	87	NUM
admet-376	36	38	products	product	NOUN
admet-376	36	39	of	of	ADP
admet-376	36	40	the	the	DET
admet-376	36	41	interaction	interaction	NOUN
admet-376	36	42	of	of	ADP
admet-376	36	43	macromolecules	macromolecule	NOUN
admet-376	36	44	with	with	ADP
admet-376	36	45	hydroxyl	hydroxyl	NOUN
admet-376	36	46	radicals	radical	NOUN
admet-376	36	47	[	[	X
admet-376	36	48	56	56	NUM
admet-376	36	49	-	-	SYM
admet-376	36	50	58	58	NUM
admet-376	36	51	]	]	PUNCT
admet-376	36	52	and	and	CCONJ
admet-376	36	53	a	a	DET
admet-376	36	54	decreased	decrease	VERB
admet-376	36	55	lifespan	lifespan	NOUN
admet-376	36	56	in	in	ADP
admet-376	36	57	model	model	NOUN
admet-376	36	58	organisms	organism	NOUN
admet-376	36	59	[	[	X
admet-376	36	60	59	59	NUM
admet-376	36	61	]	]	PUNCT
admet-376	36	62	.	.	PUNCT
admet-376	37	1	thirdly	thirdly	ADV
admet-376	37	2	,	,	PUNCT
admet-376	37	3	it	it	PRON
admet-376	37	4	acts	act	VERB
admet-376	37	5	as	as	ADP
admet-376	37	6	a	a	DET
admet-376	37	7	cytoprotectant	cytoprotectant	NOUN
admet-376	37	8	[	[	X
admet-376	37	9	48	48	NUM
admet-376	37	10	,	,	PUNCT
admet-376	37	11	60	60	NUM
admet-376	37	12	-	-	SYM
admet-376	37	13	64	64	NUM
admet-376	37	14	]	]	PUNCT
admet-376	37	15	.	.	PUNCT
admet-376	38	1	our	our	PRON
admet-376	38	2	interest	interest	NOUN
admet-376	38	3	in	in	ADP
admet-376	38	4	it	it	PRON
admet-376	38	5	here	here	ADV
admet-376	38	6	comes	come	VERB
admet-376	38	7	from	from	ADP
admet-376	38	8	the	the	DET
admet-376	38	9	fact	fact	NOUN
admet-376	38	10	that	that	SCONJ
admet-376	38	11	it	it	PRON
admet-376	38	12	has	have	AUX
admet-376	38	13	been	be	AUX
admet-376	38	14	found	find	VERB
admet-376	38	15	to	to	PART
admet-376	38	16	be	be	AUX
admet-376	38	17	the	the	DET
admet-376	38	18	natural	natural	ADJ
admet-376	38	19	(	(	PUNCT
admet-376	38	20	or	or	CCONJ
admet-376	38	21	at	at	ADP
admet-376	38	22	least	least	ADJ
admet-376	38	23	most	most	ADV
admet-376	38	24	active	active	ADJ
admet-376	38	25	)	)	PUNCT
admet-376	38	26	substrate	substrate	NOUN
admet-376	38	27	of	of	ADP
admet-376	38	28	the	the	DET
admet-376	38	29	concentrative	concentrative	NOUN
admet-376	38	30	,	,	PUNCT
admet-376	38	31	na+-dependent	na+-dependent	NUM
admet-376	38	32	transporter	transporter	NOUN
admet-376	38	33	slc22a4	slc22a4	NOUN
admet-376	38	34	[	[	X
admet-376	38	35	65	65	NUM
admet-376	38	36	-	-	SYM
admet-376	38	37	67	67	NUM
admet-376	38	38	]	]	PUNCT
admet-376	38	39	(	(	PUNCT
admet-376	38	40	once	once	ADV
admet-376	38	41	referred	refer	VERB
admet-376	38	42	to	to	ADP
admet-376	38	43	as	as	ADP
admet-376	38	44	octn1	octn1	ADJ
admet-376	38	45	,	,	PUNCT
admet-376	38	46	now	now	ADV
admet-376	38	47	the	the	DET
admet-376	38	48	ergothioneine	ergothioneine	NOUN
admet-376	38	49	transporter	transporter	NOUN
admet-376	38	50	,	,	PUNCT
admet-376	38	51	which	which	PRON
admet-376	38	52	is	be	AUX
admet-376	38	53	also	also	ADV
admet-376	38	54	capable	capable	ADJ
admet-376	38	55	of	of	ADP
admet-376	38	56	transporting	transport	VERB
admet-376	38	57	drugs	drug	NOUN
admet-376	38	58	such	such	ADJ
admet-376	38	59	as	as	ADP
admet-376	38	60	the	the	DET
admet-376	38	61	antidiabetic	antidiabetic	ADJ
admet-376	38	62	metformin	metformin	NOUN
admet-376	38	63	[	[	X
admet-376	38	64	68	68	NUM
admet-376	38	65	]	]	PUNCT
admet-376	38	66	)	)	PUNCT
admet-376	38	67	(	(	PUNCT
admet-376	38	68	for	for	SCONJ
admet-376	38	69	slc	slc	PROPN
admet-376	38	70	terminology	terminology	NOUN
admet-376	38	71	see	see	VERB
admet-376	38	72	[	[	X
admet-376	38	73	69	69	NUM
admet-376	38	74	]	]	PUNCT
admet-376	38	75	and	and	CCONJ
admet-376	38	76	http://bioparadigms.org/	http://bioparadigms.org/	NOUN
admet-376	38	77	)	)	PUNCT
admet-376	38	78	.	.	PUNCT
admet-376	39	1	it	it	PRON
admet-376	39	2	was	be	AUX
admet-376	39	3	known	know	VERB
admet-376	39	4	that	that	SCONJ
admet-376	39	5	octn1	octn1	ADJ
admet-376	39	6	transported	transport	VERB
admet-376	39	7	organic	organic	ADJ
admet-376	39	8	cations	cation	NOUN
admet-376	39	9	,	,	PUNCT
admet-376	39	10	but	but	CCONJ
admet-376	39	11	not	not	PART
admet-376	39	12	what	what	PRON
admet-376	39	13	the	the	DET
admet-376	39	14	‘	'	PUNCT
admet-376	39	15	natural	natural	ADJ
admet-376	39	16	substrate	substrate	NOUN
admet-376	39	17	’	'	PUNCT
admet-376	39	18	might	might	AUX
admet-376	39	19	be	be	AUX
admet-376	39	20	.	.	PUNCT
admet-376	40	1	thus	thus	ADV
admet-376	40	2	,	,	PUNCT
admet-376	40	3	gründemann	gründemann	PROPN
admet-376	40	4	and	and	CCONJ
admet-376	40	5	colleagues	colleague	NOUN
admet-376	41	1	[	[	X
admet-376	41	2	65	65	NUM
admet-376	41	3	]	]	PUNCT
admet-376	41	4	incubated	incubate	VERB
admet-376	41	5	cells	cell	NOUN
admet-376	41	6	with	with	ADP
admet-376	41	7	and	and	CCONJ
admet-376	41	8	without	without	ADP
admet-376	41	9	recombinant	recombinant	ADJ
admet-376	41	10	octn1	octn1	ADJ
admet-376	41	11	transporter	transporter	NOUN
admet-376	41	12	expression	expression	NOUN
admet-376	41	13	in	in	ADP
admet-376	41	14	paired	pair	VERB
admet-376	41	15	assays	assay	NOUN
admet-376	41	16	with	with	ADP
admet-376	41	17	diluted	diluted	ADJ
admet-376	41	18	plasma	plasma	NOUN
admet-376	41	19	(	(	PUNCT
admet-376	41	20	taken	take	VERB
admet-376	41	21	to	to	PART
admet-376	41	22	contain	contain	VERB
admet-376	41	23	all	all	DET
admet-376	41	24	candidate	candidate	NOUN
admet-376	41	25	substrate	substrate	NOUN
admet-376	41	26	molecules	molecule	NOUN
admet-376	41	27	)	)	PUNCT
admet-376	41	28	and	and	CCONJ
admet-376	41	29	compared	compare	VERB
admet-376	41	30	differences	difference	NOUN
admet-376	41	31	in	in	ADP
admet-376	41	32	the	the	DET
admet-376	41	33	uptake	uptake	NOUN
admet-376	41	34	of	of	ADP
admet-376	41	35	the	the	DET
admet-376	41	36	various	various	ADJ
admet-376	41	37	compounds	compound	NOUN
admet-376	41	38	by	by	ADP
admet-376	41	39	mass	mass	ADJ
admet-376	41	40	spectrometry	spectrometry	NOUN
admet-376	41	41	.	.	PUNCT
admet-376	42	1	the	the	DET
admet-376	42	2	first	first	ADJ
admet-376	42	3	substance	substance	NOUN
admet-376	42	4	identified	identify	VERB
admet-376	42	5	was	be	AUX
admet-376	42	6	proline	proline	NOUN
admet-376	42	7	betaine	betaine	NOUN
admet-376	42	8	(	(	PUNCT
admet-376	42	9	stachydrine	stachydrine	NOUN
admet-376	42	10	)	)	PUNCT
admet-376	42	11	.	.	PUNCT
admet-376	43	1	subsequent	subsequent	ADJ
admet-376	43	2	tests	test	NOUN
admet-376	43	3	on	on	ADP
admet-376	43	4	structurally	structurally	ADV
admet-376	43	5	related	relate	VERB
admet-376	43	6	molecules	molecule	NOUN
admet-376	43	7	showed	show	VERB
admet-376	43	8	that	that	SCONJ
admet-376	43	9	ergothioneine	ergothioneine	NOUN
admet-376	43	10	was	be	AUX
admet-376	43	11	much	much	ADV
admet-376	43	12	the	the	DET
admet-376	43	13	best	good	ADJ
admet-376	43	14	substrate	substrate	NOUN
admet-376	43	15	,	,	PUNCT
admet-376	43	16	with	with	ADP
admet-376	43	17	an	an	DET
admet-376	43	18	uptake	uptake	ADJ
admet-376	43	19	activity	activity	NOUN
admet-376	43	20	almost	almost	ADV
admet-376	43	21	100	100	NUM
admet-376	43	22	-	-	NUM
admet-376	43	23	fold	fold	VERB
admet-376	43	24	higher	high	ADJ
admet-376	43	25	than	than	ADP
admet-376	43	26	those	those	PRON
admet-376	43	27	for	for	ADP
admet-376	43	28	tetraethyl	tetraethyl	NOUN
admet-376	43	29	ammonium	ammonium	NOUN
admet-376	43	30	and	and	CCONJ
admet-376	43	31	carnitine	carnitine	NOUN
admet-376	43	32	[	[	X
admet-376	43	33	65	65	NUM
admet-376	43	34	]	]	PUNCT
admet-376	43	35	(	(	PUNCT
admet-376	43	36	that	that	PRON
admet-376	43	37	were	be	AUX
admet-376	43	38	previously	previously	ADV
admet-376	43	39	believed	believe	VERB
admet-376	43	40	to	to	PART
admet-376	43	41	be	be	AUX
admet-376	43	42	the	the	DET
admet-376	43	43	‘	'	PUNCT
admet-376	43	44	main	main	ADJ
admet-376	43	45	’	'	PUNCT
admet-376	43	46	substrates	substrate	NOUN
admet-376	43	47	)	)	PUNCT
admet-376	43	48	,	,	PUNCT
admet-376	43	49	and	and	CCONJ
admet-376	43	50	that	that	SCONJ
admet-376	43	51	cells	cell	NOUN
admet-376	43	52	lacking	lack	VERB
admet-376	43	53	the	the	DET
admet-376	43	54	transporter	transporter	NOUN
admet-376	43	55	were	be	AUX
admet-376	43	56	virtually	virtually	ADV
admet-376	43	57	impermeable	impermeable	ADJ
admet-376	43	58	to	to	ADP
admet-376	43	59	ergothioneine	ergothioneine	NOUN
admet-376	43	60	.	.	PUNCT
admet-376	44	1	since	since	SCONJ
admet-376	44	2	it	it	PRON
admet-376	44	3	does	do	AUX
admet-376	44	4	not	not	PART
admet-376	44	5	seem	seem	VERB
admet-376	44	6	to	to	PART
admet-376	44	7	be	be	AUX
admet-376	44	8	essential	essential	ADJ
admet-376	44	9	for	for	ADP
admet-376	44	10	the	the	DET
admet-376	44	11	growth	growth	NOUN
admet-376	44	12	of	of	ADP
admet-376	44	13	the	the	DET
admet-376	44	14	host	host	NOUN
admet-376	44	15	it	it	PRON
admet-376	44	16	has	have	AUX
admet-376	44	17	not	not	PART
admet-376	44	18	attained	attain	VERB
admet-376	44	19	the	the	DET
admet-376	44	20	status	status	NOUN
admet-376	44	21	of	of	ADP
admet-376	44	22	a	a	DET
admet-376	44	23	vitamin	vitamin	NOUN
admet-376	44	24	,	,	PUNCT
admet-376	44	25	but	but	CCONJ
admet-376	44	26	it	it	PRON
admet-376	44	27	is	be	AUX
admet-376	44	28	clearly	clearly	ADV
admet-376	44	29	highly	highly	ADV
admet-376	44	30	beneficial	beneficial	ADJ
admet-376	44	31	.	.	PUNCT
admet-376	45	1	(	(	PUNCT
admet-376	45	2	its	its	PRON
admet-376	45	3	presence	presence	NOUN
admet-376	45	4	in	in	ADP
admet-376	45	5	almost	almost	ADV
admet-376	45	6	all	all	PRON
admet-376	45	7	foodstuffs	foodstuff	NOUN
admet-376	45	8	means	mean	VERB
admet-376	45	9	that	that	SCONJ
admet-376	45	10	starvation	starvation	NOUN
admet-376	45	11	for	for	ADP
admet-376	45	12	it	it	PRON
admet-376	45	13	specifically	specifically	ADV
admet-376	45	14	,	,	PUNCT
admet-376	45	15	the	the	DET
admet-376	45	16	usual	usual	ADJ
admet-376	45	17	means	mean	NOUN
admet-376	45	18	of	of	ADP
admet-376	45	19	discovering	discover	VERB
admet-376	45	20	or	or	CCONJ
admet-376	45	21	identifying	identify	VERB
admet-376	45	22	a	a	DET
admet-376	45	23	vitamin	vitamin	NOUN
admet-376	45	24	,	,	PUNCT
admet-376	45	25	has	have	AUX
admet-376	45	26	probably	probably	ADV
admet-376	45	27	never	never	ADV
admet-376	45	28	occurred	occur	VERB
admet-376	45	29	.	.	PUNCT
admet-376	45	30	)	)	PUNCT
admet-376	46	1	the	the	DET
admet-376	46	2	same	same	ADJ
admet-376	46	3	may	may	AUX
admet-376	46	4	generally	generally	ADV
admet-376	46	5	be	be	AUX
admet-376	46	6	said	say	VERB
admet-376	46	7	to	to	PART
admet-376	46	8	be	be	AUX
admet-376	46	9	true	true	ADJ
admet-376	46	10	of	of	ADP
admet-376	46	11	other	other	ADJ
admet-376	46	12	nutritionally	nutritionally	ADV
admet-376	46	13	beneficial	beneficial	ADJ
admet-376	46	14	molecules	molecule	NOUN
admet-376	46	15	of	of	ADP
admet-376	46	16	plant	plant	NOUN
admet-376	46	17	origin	origin	NOUN
admet-376	46	18	,	,	PUNCT
admet-376	46	19	of	of	ADP
admet-376	46	20	which	which	PRON
admet-376	46	21	the	the	DET
admet-376	46	22	flavonoids	flavonoid	NOUN
admet-376	46	23	are	be	AUX
admet-376	46	24	among	among	ADP
admet-376	46	25	the	the	DET
admet-376	46	26	best	well	ADV
admet-376	46	27	known	know	VERB
admet-376	46	28	.	.	PUNCT
admet-376	47	1	indeed	indeed	ADV
admet-376	47	2	,	,	PUNCT
admet-376	47	3	in	in	ADP
admet-376	47	4	a	a	DET
admet-376	47	5	similar	similar	ADJ
admet-376	47	6	way	way	NOUN
admet-376	47	7	,	,	PUNCT
admet-376	47	8	it	it	PRON
admet-376	47	9	appears	appear	VERB
admet-376	47	10	that	that	SCONJ
admet-376	47	11	specific	specific	ADJ
admet-376	47	12	transporters	transporter	NOUN
admet-376	47	13	for	for	ADP
admet-376	47	14	flavonoid	flavonoid	NOUN
admet-376	47	15	-	-	PUNCT
admet-376	47	16	type	type	NOUN
admet-376	47	17	molecules	molecule	NOUN
admet-376	47	18	also	also	ADV
admet-376	47	19	exist	exist	VERB
admet-376	47	20	[	[	PRON
admet-376	47	21	7072	7072	NUM
admet-376	47	22	]	]	PUNCT
admet-376	47	23	,	,	PUNCT
admet-376	47	24	albeit	albeit	SCONJ
admet-376	47	25	their	their	PRON
admet-376	47	26	molecular	molecular	ADJ
admet-376	47	27	taxonomy	taxonomy	NOUN
admet-376	47	28	remains	remain	VERB
admet-376	47	29	unclear	unclear	ADJ
admet-376	47	30	[	[	X
admet-376	47	31	73	73	NUM
admet-376	47	32	]	]	PUNCT
admet-376	47	33	.	.	PUNCT
admet-376	48	1	this	this	PRON
admet-376	48	2	said	say	VERB
admet-376	48	3	,	,	PUNCT
admet-376	48	4	a	a	DET
admet-376	48	5	transporter	transporter	NOUN
admet-376	48	6	in	in	ADP
admet-376	48	7	plants	plant	NOUN
admet-376	48	8	[	[	X
admet-376	48	9	74	74	NUM
admet-376	48	10	]	]	PUNCT
admet-376	48	11	shows	show	VERB
admet-376	48	12	significant	significant	ADJ
admet-376	48	13	homology	homology	NOUN
admet-376	48	14	to	to	PART
admet-376	48	15	bilitranslocase	bilitranslocase	VERB
admet-376	48	16	,	,	PUNCT
admet-376	48	17	a	a	DET
admet-376	48	18	liver	liver	NOUN
admet-376	48	19	uptake	uptake	ADJ
admet-376	48	20	transporter	transporter	NOUN
admet-376	48	21	for	for	ADP
admet-376	48	22	blood	blood	NOUN
admet-376	48	23	-	-	PUNCT
admet-376	48	24	derived	derive	VERB
admet-376	48	25	bilirubin	bilirubin	NOUN
admet-376	48	26	,	,	PUNCT
admet-376	48	27	and	and	CCONJ
admet-376	48	28	bilitranslocase	bilitranslocase	NOUN
admet-376	48	29	has	have	AUX
admet-376	48	30	been	be	AUX
admet-376	48	31	shown	show	VERB
admet-376	48	32	to	to	PART
admet-376	48	33	transport	transport	VERB
admet-376	48	34	dietary	dietary	ADJ
admet-376	48	35	flavonoids	flavonoid	NOUN
admet-376	48	36	[	[	X
admet-376	48	37	75	75	NUM
admet-376	48	38	]	]	PUNCT
admet-376	48	39	,	,	PUNCT
admet-376	48	40	in	in	ADP
admet-376	48	41	particular	particular	ADJ
admet-376	48	42	anthocyanins	anthocyanin	NOUN
admet-376	48	43	[	[	X
admet-376	48	44	76	76	NUM
admet-376	48	45	-	-	SYM
admet-376	48	46	79	79	NUM
admet-376	48	47	]	]	PUNCT
admet-376	48	48	.	.	PUNCT
admet-376	49	1	thus	thus	ADV
admet-376	49	2	we	we	PRON
admet-376	49	3	are	be	AUX
admet-376	49	4	led	lead	VERB
admet-376	49	5	to	to	ADP
admet-376	49	6	the	the	DET
admet-376	49	7	view	view	NOUN
admet-376	49	8	that	that	SCONJ
admet-376	49	9	we	we	PRON
admet-376	49	10	should	should	AUX
admet-376	49	11	consider	consider	VERB
admet-376	49	12	as	as	ADP
admet-376	49	13	substrates	substrate	NOUN
admet-376	49	14	for	for	ADP
admet-376	49	15	mammalian	mammalian	ADJ
admet-376	49	16	transporters	transporter	NOUN
admet-376	49	17	not	not	PART
admet-376	49	18	only	only	ADV
admet-376	49	19	the	the	DET
admet-376	49	20	known	know	VERB
admet-376	49	21	intermediary	intermediary	ADJ
admet-376	49	22	metabolites	metabolite	NOUN
admet-376	49	23	,	,	PUNCT
admet-376	49	24	but	but	CCONJ
admet-376	49	25	also	also	ADV
admet-376	49	26	a	a	DET
admet-376	49	27	variety	variety	NOUN
admet-376	49	28	of	of	ADP
admet-376	49	29	(	(	PUNCT
admet-376	49	30	mainly	mainly	ADV
admet-376	49	31	plant	plant	NOUN
admet-376	49	32	and	and	CCONJ
admet-376	49	33	microbial	microbial	ADJ
admet-376	49	34	)	)	PUNCT
admet-376	49	35	dietary	dietary	ADJ
admet-376	49	36	molecules	molecule	NOUN
admet-376	49	37	that	that	PRON
admet-376	49	38	are	be	AUX
admet-376	49	39	bioactive	bioactive	ADJ
admet-376	49	40	and	and	CCONJ
admet-376	49	41	beneficial	beneficial	ADJ
admet-376	49	42	,	,	PUNCT
admet-376	49	43	even	even	ADV
admet-376	49	44	if	if	SCONJ
admet-376	49	45	not	not	PART
admet-376	49	46	essential	essential	ADJ
admet-376	49	47	.	.	PUNCT
admet-376	50	1	this	this	PRON
admet-376	50	2	is	be	AUX
admet-376	50	3	because	because	SCONJ
admet-376	50	4	organisms	organism	NOUN
admet-376	50	5	will	will	AUX
admet-376	50	6	have	have	AUX
admet-376	50	7	coevolved	coevolve	VERB
admet-376	50	8	with	with	ADP
admet-376	50	9	them	they	PRON
admet-376	50	10	for	for	ADP
admet-376	50	11	millions	million	NOUN
admet-376	50	12	of	of	ADP
admet-376	50	13	years	year	NOUN
admet-376	50	14	since	since	SCONJ
admet-376	50	15	‘	'	PUNCT
admet-376	50	16	animals	animal	NOUN
admet-376	50	17	’	'	PUNCT
admet-376	50	18	began	begin	VERB
admet-376	50	19	to	to	PART
admet-376	50	20	consume	consume	VERB
admet-376	50	21	plants	plant	NOUN
admet-376	50	22	[	[	X
admet-376	50	23	80	80	NUM
admet-376	50	24	-	-	SYM
admet-376	50	25	83	83	NUM
admet-376	50	26	]	]	PUNCT
admet-376	50	27	and	and	CCONJ
admet-376	50	28	to	to	PART
admet-376	50	29	harbour	harbour	VERB
admet-376	50	30	microbes	microbe	NOUN
admet-376	50	31	[	[	X
admet-376	50	32	84	84	NUM
admet-376	50	33	,	,	PUNCT
admet-376	50	34	85	85	NUM
admet-376	50	35	]	]	PUNCT
admet-376	50	36	.	.	PUNCT
admet-376	51	1	even	even	ADV
admet-376	51	2	stronger	strong	ADJ
admet-376	51	3	natural	natural	ADJ
admet-376	51	4	selection	selection	NOUN
admet-376	51	5	may	may	AUX
admet-376	51	6	be	be	AUX
admet-376	51	7	expected	expect	VERB
admet-376	51	8	since	since	SCONJ
admet-376	51	9	the	the	DET
admet-376	51	10	time	time	NOUN
admet-376	51	11	that	that	PRON
admet-376	51	12	such	such	ADJ
admet-376	51	13	plants	plant	NOUN
admet-376	51	14	actually	actually	ADV
admet-376	51	15	began	begin	VERB
admet-376	51	16	to	to	PART
admet-376	51	17	be	be	AUX
admet-376	51	18	utilised	utilise	VERB
admet-376	51	19	in	in	ADP
admet-376	51	20	agriculture	agriculture	NOUN
admet-376	51	21	[	[	X
admet-376	51	22	86	86	NUM
admet-376	51	23	]	]	PUNCT
admet-376	51	24	or	or	CCONJ
admet-376	51	25	prescribed	prescribe	VERB
admet-376	51	26	for	for	ADP
admet-376	51	27	medical	medical	ADJ
admet-376	51	28	benefit	benefit	NOUN
admet-376	51	29	[	[	X
admet-376	51	30	87	87	NUM
admet-376	51	31	,	,	PUNCT
admet-376	51	32	88	88	NUM
admet-376	51	33	]	]	PUNCT
admet-376	51	34	,	,	PUNCT
admet-376	51	35	as	as	ADP
admet-376	51	36	in	in	ADP
admet-376	51	37	ayurvedic	ayurvedic	NOUN
admet-376	51	38	[	[	X
admet-376	51	39	89	89	NUM
admet-376	51	40	-	-	SYM
admet-376	51	41	91	91	NUM
admet-376	51	42	]	]	PUNCT
admet-376	51	43	and	and	CCONJ
admet-376	51	44	chinese	chinese	ADJ
admet-376	51	45	herbal	herbal	ADJ
admet-376	51	46	medicine	medicine	NOUN
admet-376	52	1	[	[	X
admet-376	52	2	90	90	NUM
admet-376	52	3	,	,	PUNCT
admet-376	52	4	92	92	NUM
admet-376	52	5	,	,	PUNCT
admet-376	52	6	93	93	NUM
admet-376	52	7	]	]	PUNCT
admet-376	52	8	(	(	PUNCT
admet-376	52	9	ca	ca	NOUN
admet-376	52	10	5	5	NUM
admet-376	52	11	-	-	PUNCT
admet-376	52	12	8000y	8000y	NUM
admet-376	52	13	bp	bp	NOUN
admet-376	52	14	)	)	PUNCT
admet-376	52	15	.	.	PUNCT
admet-376	53	1	if	if	SCONJ
admet-376	53	2	this	this	PRON
admet-376	53	3	is	be	AUX
admet-376	53	4	the	the	DET
admet-376	53	5	case	case	NOUN
admet-376	53	6	,	,	PUNCT
admet-376	53	7	we	we	PRON
admet-376	53	8	would	would	AUX
admet-376	53	9	expect	expect	VERB
admet-376	53	10	to	to	PART
admet-376	53	11	find	find	VERB
admet-376	53	12	even	even	ADV
admet-376	53	13	more	more	ADJ
admet-376	53	14	structural	structural	ADJ
admet-376	53	15	similarities	similarity	NOUN
admet-376	53	16	between	between	ADP
admet-376	53	17	drugs	drug	NOUN
admet-376	53	18	and	and	CCONJ
admet-376	53	19	such	such	ADJ
admet-376	53	20	natural	natural	ADJ
admet-376	53	21	products	product	NOUN
admet-376	53	22	when	when	SCONJ
admet-376	53	23	these	these	PRON
admet-376	53	24	are	be	AUX
admet-376	53	25	compared	compare	VERB
admet-376	53	26	to	to	ADP
admet-376	53	27	drugendogenite	drugendogenite	PROPN
admet-376	53	28	similarities	similarity	NOUN
admet-376	53	29	(	(	PUNCT
admet-376	53	30	and	and	CCONJ
admet-376	53	31	actually	actually	ADV
admet-376	53	32	this	this	PRON
admet-376	53	33	proved	prove	VERB
admet-376	53	34	to	to	PART
admet-376	53	35	be	be	AUX
admet-376	53	36	the	the	DET
admet-376	53	37	case	case	NOUN
admet-376	53	38	in	in	ADP
admet-376	53	39	a	a	DET
admet-376	53	40	pilot	pilot	NOUN
admet-376	53	41	study	study	NOUN
admet-376	53	42	;	;	PUNCT
admet-376	53	43	figure	figure	VERB
admet-376	53	44	5c	5c	NOUN
admet-376	53	45	of	of	ADP
admet-376	53	46	[	[	X
admet-376	53	47	22	22	NUM
admet-376	53	48	]	]	PUNCT
admet-376	53	49	)	)	PUNCT
admet-376	53	50	.	.	PUNCT
admet-376	54	1	one	one	NUM
admet-376	54	2	purpose	purpose	NOUN
admet-376	54	3	of	of	ADP
admet-376	54	4	the	the	DET
admet-376	54	5	present	present	ADJ
admet-376	54	6	paper	paper	NOUN
admet-376	54	7	was	be	AUX
admet-376	54	8	to	to	PART
admet-376	54	9	test	test	VERB
admet-376	54	10	this	this	DET
admet-376	54	11	idea	idea	NOUN
admet-376	54	12	explicitly	explicitly	ADV
admet-376	54	13	and	and	CCONJ
admet-376	54	14	in	in	ADP
admet-376	54	15	much	much	ADV
admet-376	54	16	more	more	ADJ
admet-376	54	17	detail	detail	NOUN
admet-376	54	18	.	.	PUNCT
admet-376	55	1	indeed	indeed	ADV
admet-376	55	2	,	,	PUNCT
admet-376	55	3	it	it	PRON
admet-376	55	4	transpires	transpire	VERB
admet-376	55	5	(	(	PUNCT
admet-376	55	6	see	see	VERB
admet-376	55	7	a	a	DET
admet-376	55	8	detailed	detailed	ADJ
admet-376	55	9	analysis	analysis	NOUN
admet-376	55	10	in	in	ADP
admet-376	55	11	the	the	DET
admet-376	55	12	body	body	NOUN
admet-376	55	13	of	of	ADP
admet-376	55	14	this	this	DET
admet-376	55	15	paper	paper	NOUN
admet-376	55	16	)	)	PUNCT
admet-376	55	17	that	that	SCONJ
admet-376	55	18	many	many	ADJ
admet-376	55	19	of	of	ADP
admet-376	55	20	the	the	DET
admet-376	55	21	least	least	ADJ
admet-376	55	22	human	human	NOUN
admet-376	55	23	-	-	PUNCT
admet-376	55	24	endogenite	endogenite	NOUN
admet-376	55	25	-	-	PUNCT
admet-376	55	26	like	like	NOUN
admet-376	55	27	marketed	market	VERB
admet-376	55	28	drugs	drug	NOUN
admet-376	55	29	are	be	AUX
admet-376	55	30	considerably	considerably	ADV
admet-376	55	31	closer	close	ADJ
admet-376	55	32	in	in	ADP
admet-376	55	33	structure	structure	NOUN
admet-376	55	34	to	to	ADP
admet-376	55	35	common	common	ADJ
admet-376	55	36	plant	plant	NOUN
admet-376	55	37	and	and	CCONJ
admet-376	55	38	microbial	microbial	ADJ
admet-376	55	39	secondary	secondary	ADJ
admet-376	55	40	products	product	NOUN
admet-376	55	41	than	than	SCONJ
admet-376	55	42	they	they	PRON
admet-376	55	43	are	be	AUX
admet-376	55	44	to	to	ADP
admet-376	55	45	endogenites	endogenite	NOUN
admet-376	55	46	.	.	PUNCT
admet-376	56	1	if	if	SCONJ
admet-376	56	2	we	we	PRON
admet-376	56	3	take	take	VERB
admet-376	56	4	the	the	DET
admet-376	56	5	term	term	NOUN
admet-376	56	6	‘	'	PUNCT
admet-376	56	7	natural	natural	ADJ
admet-376	56	8	substrate	substrate	NOUN
admet-376	56	9	’	'	PUNCT
admet-376	56	10	to	to	PART
admet-376	56	11	mean	mean	VERB
admet-376	56	12	a	a	DET
admet-376	56	13	substance	substance	NOUN
admet-376	56	14	to	to	PART
admet-376	56	15	which	which	PRON
admet-376	56	16	an	an	DET
admet-376	56	17	organism	organism	NOUN
admet-376	56	18	has	have	AUX
admet-376	56	19	been	be	AUX
admet-376	56	20	exposed	expose	VERB
admet-376	56	21	and	and	CCONJ
admet-376	56	22	for	for	ADP
admet-376	56	23	which	which	PRON
admet-376	56	24	a	a	DET
admet-376	56	25	transporter	transporter	NOUN
admet-376	56	26	has	have	VERB
admet-376	56	27	a	a	DET
admet-376	56	28	particularly	particularly	ADV
admet-376	56	29	high	high	ADJ
admet-376	56	30	kcat	kcat	NOUN
admet-376	56	31	or	or	CCONJ
admet-376	56	32	kcat	kcat	NOUN
admet-376	56	33	/	/	SYM
admet-376	56	34	km	km	NOUN
admet-376	56	35	,	,	PUNCT
admet-376	56	36	it	it	PRON
admet-376	56	37	is	be	AUX
admet-376	56	38	reasonable	reasonable	ADJ
admet-376	56	39	to	to	PART
admet-376	56	40	refer	refer	VERB
admet-376	56	41	to	to	ADP
admet-376	56	42	such	such	DET
admet-376	56	43	a	a	DET
admet-376	56	44	molecule	molecule	NOUN
admet-376	56	45	as	as	ADP
admet-376	56	46	a	a	DET
admet-376	56	47	‘	'	PUNCT
admet-376	56	48	natural	natural	ADJ
admet-376	56	49	substrate	substrate	NOUN
admet-376	56	50	’	'	PUNCT
admet-376	56	51	,	,	PUNCT
admet-376	56	52	as	as	ADP
admet-376	56	53	in	in	ADP
admet-376	56	54	the	the	DET
admet-376	56	55	ergothioneine	ergothioneine	NOUN
admet-376	56	56	/	/	SYM
admet-376	56	57	slc22a4	slc22a4	PROPN
admet-376	56	58	example	example	NOUN
admet-376	56	59	above	above	ADV
admet-376	56	60	.	.	PUNCT
admet-376	57	1	another	another	DET
admet-376	57	2	exogenous	exogenous	ADJ
admet-376	57	3	molecule	molecule	NOUN
admet-376	57	4	that	that	PRON
admet-376	57	5	seems	seem	VERB
admet-376	57	6	similarly	similarly	ADV
admet-376	57	7	valuable	valuable	ADJ
admet-376	57	8	to	to	ADP
admet-376	57	9	mammals	mammal	NOUN
admet-376	57	10	[	[	X
admet-376	57	11	94	94	NUM
admet-376	57	12	-	-	SYM
admet-376	57	13	105	105	NUM
admet-376	57	14	]	]	PUNCT
admet-376	57	15	and	and	CCONJ
admet-376	57	16	other	other	ADJ
admet-376	57	17	organisms	organism	NOUN
admet-376	57	18	[	[	X
admet-376	57	19	106	106	NUM
admet-376	57	20	]	]	X
admet-376	57	21	,	,	PUNCT
admet-376	57	22	albeit	albeit	SCONJ
admet-376	57	23	its	its	PRON
admet-376	57	24	uptake	uptake	ADJ
admet-376	57	25	transporter	transporter	NOUN
admet-376	57	26	is	be	AUX
admet-376	57	27	not	not	PART
admet-376	57	28	yet	yet	ADV
admet-376	57	29	known	know	VERB
admet-376	57	30	,	,	PUNCT
admet-376	57	31	is	be	AUX
admet-376	57	32	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	57	33	quinone	quinone	NOUN
admet-376	57	34	(	(	PUNCT
admet-376	57	35	pqq	pqq	NOUN
admet-376	57	36	)	)	PUNCT
admet-376	58	1	[	[	X
admet-376	58	2	107	107	NUM
admet-376	58	3	]	]	PUNCT
admet-376	58	4	,	,	PUNCT
admet-376	58	5	also	also	ADV
admet-376	58	6	known	know	VERB
admet-376	58	7	as	as	ADP
admet-376	58	8	methoxatin	methoxatin	NOUN
admet-376	58	9	,	,	PUNCT
admet-376	58	10	a	a	DET
admet-376	58	11	redox	redox	ADJ
admet-376	58	12	cofactor	cofactor	NOUN
admet-376	58	13	normally	normally	ADV
admet-376	58	14	associated	associate	VERB
admet-376	58	15	with	with	ADP
admet-376	58	16	prokaryotes	prokaryote	NOUN
admet-376	58	17	[	[	X
admet-376	58	18	108	108	NUM
admet-376	58	19	,	,	PUNCT
admet-376	58	20	109	109	NUM
admet-376	58	21	]	]	PUNCT
admet-376	58	22	.	.	PUNCT
admet-376	59	1	how	how	SCONJ
admet-376	59	2	similar	similar	ADJ
admet-376	59	3	is	be	AUX
admet-376	59	4	similar	similar	ADJ
admet-376	59	5	?	?	PUNCT
admet-376	60	1	although	although	SCONJ
admet-376	60	2	the	the	DET
admet-376	60	3	concept	concept	NOUN
admet-376	60	4	of	of	ADP
admet-376	60	5	what	what	PRON
admet-376	60	6	counts	count	VERB
admet-376	60	7	as	as	ADP
admet-376	60	8	‘	'	PUNCT
admet-376	60	9	significantly	significantly	ADV
admet-376	60	10	similar	similar	ADJ
admet-376	60	11	’	'	PUNCT
admet-376	60	12	must	must	AUX
admet-376	60	13	be	be	AUX
admet-376	60	14	recognised	recognise	VERB
admet-376	60	15	as	as	ADP
admet-376	60	16	highly	highly	ADV
admet-376	60	17	important	important	ADJ
admet-376	60	18	in	in	ADP
admet-376	60	19	cheminformatics	cheminformatic	NOUN
admet-376	60	20	,	,	PUNCT
admet-376	60	21	there	there	PRON
admet-376	60	22	has	have	AUX
admet-376	60	23	been	be	AUX
admet-376	60	24	surprisingly	surprisingly	ADV
admet-376	60	25	little	little	ADJ
admet-376	60	26	work	work	NOUN
admet-376	60	27	done	do	VERB
admet-376	60	28	on	on	ADP
admet-376	60	29	it	it	PRON
admet-376	60	30	;	;	PUNCT
admet-376	60	31	most	most	ADJ
admet-376	60	32	of	of	ADP
admet-376	60	33	it	it	PRON
admet-376	60	34	has	have	AUX
admet-376	60	35	involved	involve	VERB
admet-376	60	36	assessing	assess	VERB
admet-376	60	37	the	the	DET
admet-376	60	38	likelihood	likelihood	NOUN
admet-376	60	39	that	that	SCONJ
admet-376	60	40	a	a	DET
admet-376	60	41	given	give	VERB
admet-376	60	42	similarity	similarity	NOUN
admet-376	60	43	could	could	AUX
admet-376	60	44	be	be	AUX
admet-376	60	45	achieved	achieve	VERB
admet-376	60	46	from	from	ADP
admet-376	60	47	a	a	DET
admet-376	60	48	(	(	PUNCT
admet-376	60	49	more	more	ADJ
admet-376	60	50	or	or	CCONJ
admet-376	60	51	less	less	ADV
admet-376	60	52	random	random	ADJ
admet-376	60	53	)	)	PUNCT
admet-376	60	54	distribution	distribution	NOUN
admet-376	60	55	of	of	ADP
admet-376	60	56	chemicals	chemical	NOUN
admet-376	60	57	http://bioparadigms.org/	http://bioparadigms.org/	PROPN
admet-376	60	58	o'hagan	o'hagan	PROPN
admet-376	60	59	&	&	CCONJ
admet-376	60	60	kell	kell	PROPN
admet-376	60	61	admet	admet	PROPN
admet-376	60	62	&	&	CCONJ
admet-376	60	63	dmpk	dmpk	PROPN
admet-376	60	64	5(2	5(2	NUM
admet-376	60	65	)	)	PUNCT
admet-376	60	66	(	(	PUNCT
admet-376	60	67	2017	2017	NUM
admet-376	60	68	)	)	PUNCT
admet-376	60	69	85	85	NUM
admet-376	60	70	-	-	SYM
admet-376	60	71	125	125	NUM
admet-376	60	72	88	88	NUM
admet-376	61	1	[	[	SYM
admet-376	61	2	34	34	NUM
admet-376	61	3	,	,	PUNCT
admet-376	61	4	110	110	NUM
admet-376	61	5	-	-	SYM
admet-376	61	6	114	114	NUM
admet-376	61	7	]	]	PUNCT
admet-376	61	8	.	.	PUNCT
admet-376	62	1	given	give	VERB
admet-376	62	2	that	that	SCONJ
admet-376	62	3	our	our	PRON
admet-376	62	4	original	original	ADJ
admet-376	62	5	,	,	PUNCT
admet-376	62	6	underlying	underlying	ADJ
admet-376	62	7	interest	interest	NOUN
admet-376	62	8	is	be	AUX
admet-376	62	9	in	in	ADP
admet-376	62	10	understanding	understand	VERB
admet-376	62	11	those	those	DET
admet-376	62	12	features	feature	NOUN
admet-376	62	13	of	of	ADP
admet-376	62	14	drug	drug	NOUN
admet-376	62	15	and	and	CCONJ
admet-376	62	16	endogenous	endogenous	ADJ
admet-376	62	17	metabolite	metabolite	NOUN
admet-376	62	18	structures	structure	NOUN
admet-376	62	19	that	that	PRON
admet-376	62	20	tend	tend	VERB
admet-376	62	21	to	to	PART
admet-376	62	22	determine	determine	VERB
admet-376	62	23	whether	whether	SCONJ
admet-376	62	24	a	a	DET
admet-376	62	25	drug	drug	NOUN
admet-376	62	26	is	be	AUX
admet-376	62	27	closer	close	ADJ
admet-376	62	28	to	to	ADP
admet-376	62	29	or	or	CCONJ
admet-376	62	30	far	far	ADV
admet-376	62	31	from	from	ADP
admet-376	62	32	being	be	AUX
admet-376	62	33	most	most	ADV
admet-376	62	34	similar	similar	ADJ
admet-376	62	35	to	to	ADP
admet-376	62	36	a	a	DET
admet-376	62	37	specific	specific	ADJ
admet-376	62	38	endogenous	endogenous	ADJ
admet-376	62	39	(	(	PUNCT
admet-376	62	40	or	or	CCONJ
admet-376	62	41	other	other	ADJ
admet-376	62	42	)	)	PUNCT
admet-376	62	43	metabolite	metabolite	NOUN
admet-376	62	44	,	,	PUNCT
admet-376	62	45	the	the	DET
admet-376	62	46	question	question	NOUN
admet-376	62	47	is	be	AUX
admet-376	62	48	important	important	ADJ
admet-376	62	49	(	(	PUNCT
admet-376	62	50	but	but	CCONJ
admet-376	62	51	the	the	DET
admet-376	62	52	distribution	distribution	NOUN
admet-376	62	53	of	of	ADP
admet-376	62	54	chemical	chemical	NOUN
admet-376	62	55	structures	structure	NOUN
admet-376	62	56	is	be	AUX
admet-376	62	57	far	far	ADV
admet-376	62	58	from	from	ADP
admet-376	62	59	random	random	ADJ
admet-376	62	60	,	,	PUNCT
admet-376	62	61	one	one	NUM
admet-376	62	62	having	having	AUX
admet-376	62	63	been	be	AUX
admet-376	62	64	selected	select	VERB
admet-376	62	65	by	by	ADP
admet-376	62	66	natural	natural	ADJ
admet-376	62	67	evolution	evolution	NOUN
admet-376	62	68	,	,	PUNCT
admet-376	62	69	the	the	DET
admet-376	62	70	other	other	ADJ
admet-376	62	71	via	via	ADP
admet-376	62	72	the	the	DET
admet-376	62	73	processes	process	NOUN
admet-376	62	74	of	of	ADP
admet-376	62	75	drug	drug	NOUN
admet-376	62	76	discovery	discovery	NOUN
admet-376	62	77	)	)	PUNCT
admet-376	62	78	.	.	PUNCT
admet-376	63	1	thus	thus	ADV
admet-376	63	2	,	,	PUNCT
admet-376	63	3	the	the	DET
admet-376	63	4	first	first	ADJ
admet-376	63	5	part	part	NOUN
admet-376	63	6	of	of	ADP
admet-376	63	7	the	the	DET
admet-376	63	8	present	present	ADJ
admet-376	63	9	paper	paper	NOUN
admet-376	63	10	analyses	analysis	NOUN
admet-376	63	11	that	that	DET
admet-376	63	12	question	question	NOUN
admet-376	63	13	.	.	PUNCT
admet-376	64	1	the	the	DET
admet-376	64	2	conclusion	conclusion	NOUN
admet-376	64	3	is	be	AUX
admet-376	64	4	that	that	SCONJ
admet-376	64	5	the	the	DET
admet-376	64	6	rank	rank	NOUN
admet-376	64	7	order	order	NOUN
admet-376	64	8	is	be	AUX
admet-376	64	9	reasonably	reasonably	ADV
admet-376	64	10	preserved	preserve	VERB
admet-376	64	11	for	for	ADP
admet-376	64	12	only	only	ADV
admet-376	64	13	a	a	DET
admet-376	64	14	small	small	ADJ
admet-376	64	15	fraction	fraction	NOUN
admet-376	64	16	–	–	PUNCT
admet-376	64	17	some	some	DET
admet-376	64	18	5	5	NUM
admet-376	64	19	-	-	SYM
admet-376	64	20	10	10	NUM
admet-376	64	21	%	%	NOUN
admet-376	64	22	–	–	PUNCT
admet-376	64	23	of	of	ADP
admet-376	64	24	those	those	DET
admet-376	64	25	drugs	drug	NOUN
admet-376	64	26	that	that	PRON
admet-376	64	27	are	be	AUX
admet-376	64	28	most	most	ADV
admet-376	64	29	similar	similar	ADJ
admet-376	64	30	to	to	ADP
admet-376	64	31	an	an	DET
admet-376	64	32	endogenite	endogenite	NOUN
admet-376	64	33	,	,	PUNCT
admet-376	64	34	but	but	CCONJ
admet-376	64	35	that	that	SCONJ
admet-376	64	36	for	for	ADP
admet-376	64	37	the	the	DET
admet-376	64	38	vast	vast	ADJ
admet-376	64	39	majority	majority	NOUN
admet-376	64	40	of	of	ADP
admet-376	64	41	drugs	drug	NOUN
admet-376	64	42	not	not	PART
admet-376	64	43	only	only	ADV
admet-376	64	44	the	the	DET
admet-376	64	45	numerical	numerical	ADJ
admet-376	64	46	value	value	NOUN
admet-376	64	47	of	of	ADP
admet-376	64	48	the	the	DET
admet-376	64	49	(	(	PUNCT
admet-376	64	50	tanimoto	tanimoto	NOUN
admet-376	64	51	)	)	PUNCT
admet-376	64	52	similarity	similarity	NOUN
admet-376	64	53	but	but	CCONJ
admet-376	64	54	also	also	ADV
admet-376	64	55	the	the	DET
admet-376	64	56	rank	rank	NOUN
admet-376	64	57	order	order	NOUN
admet-376	64	58	depends	depend	VERB
admet-376	64	59	very	very	ADV
admet-376	64	60	strongly	strongly	ADV
admet-376	64	61	indeed	indeed	ADV
admet-376	64	62	on	on	ADP
admet-376	64	63	the	the	DET
admet-376	64	64	encoding	encoding	NOUN
admet-376	64	65	used	use	VERB
admet-376	64	66	.	.	PUNCT
admet-376	65	1	however	however	ADV
admet-376	65	2	,	,	PUNCT
admet-376	65	3	the	the	DET
admet-376	65	4	fraction	fraction	NOUN
admet-376	65	5	of	of	ADP
admet-376	65	6	drugs	drug	NOUN
admet-376	65	7	for	for	ADP
admet-376	65	8	which	which	PRON
admet-376	65	9	different	different	ADJ
admet-376	65	10	fingerprinting	fingerprint	VERB
admet-376	65	11	methods	method	NOUN
admet-376	65	12	of	of	ADP
admet-376	65	13	encoding	encode	VERB
admet-376	65	14	do	do	AUX
admet-376	65	15	give	give	VERB
admet-376	65	16	consensual	consensual	ADJ
admet-376	65	17	answers	answer	NOUN
admet-376	65	18	(	(	PUNCT
admet-376	65	19	tanimoto	tanimoto	NOUN
admet-376	65	20	similarity	similarity	NOUN
admet-376	65	21	≥	≥	NUM
admet-376	65	22	0.8	0.8	NUM
admet-376	65	23	,	,	PUNCT
admet-376	65	24	for	for	ADP
admet-376	65	25	instance	instance	NOUN
admet-376	65	26	)	)	PUNCT
admet-376	65	27	provides	provide	VERB
admet-376	65	28	a	a	DET
admet-376	65	29	defensible	defensible	ADJ
admet-376	65	30	cut	cut	NOUN
admet-376	65	31	-	-	PUNCT
admet-376	65	32	off	off	NOUN
admet-376	65	33	for	for	ADP
admet-376	65	34	what	what	PRON
admet-376	65	35	really	really	ADV
admet-376	65	36	counts	count	VERB
admet-376	65	37	as	as	ADP
admet-376	65	38	‘	'	PUNCT
admet-376	65	39	significantly	significantly	ADV
admet-376	65	40	similar	similar	ADJ
admet-376	65	41	’	'	PUNCT
admet-376	65	42	.	.	PUNCT
admet-376	66	1	this	this	PRON
admet-376	66	2	leads	lead	VERB
admet-376	66	3	to	to	ADP
admet-376	66	4	a	a	DET
admet-376	66	5	second	second	ADJ
admet-376	66	6	part	part	NOUN
admet-376	66	7	,	,	PUNCT
admet-376	66	8	where	where	SCONJ
admet-376	66	9	we	we	PRON
admet-376	66	10	establish	establish	VERB
admet-376	66	11	that	that	DET
admet-376	66	12	plantand	plantand	NOUN
admet-376	66	13	microbially	microbially	ADV
admet-376	66	14	derived	derive	VERB
admet-376	66	15	natural	natural	ADJ
admet-376	66	16	products	product	NOUN
admet-376	66	17	have	have	VERB
admet-376	66	18	a	a	DET
admet-376	66	19	much	much	ADV
admet-376	66	20	greater	great	ADJ
admet-376	66	21	similarity	similarity	NOUN
admet-376	66	22	to	to	AUX
admet-376	66	23	marketed	market	VERB
admet-376	66	24	drugs	drug	NOUN
admet-376	66	25	than	than	SCONJ
admet-376	66	26	do	do	VERB
admet-376	66	27	the	the	DET
admet-376	66	28	endogenous	endogenous	ADJ
admet-376	66	29	metabolites	metabolite	NOUN
admet-376	66	30	of	of	ADP
admet-376	66	31	recon2	recon2	NOUN
admet-376	66	32	,	,	PUNCT
admet-376	66	33	and	and	CCONJ
admet-376	66	34	that	that	SCONJ
admet-376	66	35	they	they	PRON
admet-376	66	36	are	be	AUX
admet-376	66	37	in	in	ADP
admet-376	66	38	fact	fact	NOUN
admet-376	66	39	almost	almost	ADV
admet-376	66	40	certainly	certainly	ADV
admet-376	66	41	the	the	DET
admet-376	66	42	more	more	ADV
admet-376	66	43	common	common	ADJ
admet-376	66	44	‘	'	PUNCT
admet-376	66	45	natural	natural	ADJ
admet-376	66	46	’	'	PUNCT
admet-376	66	47	substrates	substrate	NOUN
admet-376	66	48	of	of	ADP
admet-376	66	49	the	the	DET
admet-376	66	50	transporters	transporter	NOUN
admet-376	66	51	on	on	ADP
admet-376	66	52	which	which	PRON
admet-376	66	53	pharmaceutical	pharmaceutical	ADJ
admet-376	66	54	drugs	drug	NOUN
admet-376	66	55	hitchhike	hitchhike	VERB
admet-376	66	56	.	.	PUNCT
admet-376	67	1	this	this	PRON
admet-376	67	2	has	have	VERB
admet-376	67	3	profound	profound	ADJ
admet-376	67	4	implication	implication	NOUN
admet-376	67	5	for	for	ADP
admet-376	67	6	our	our	PRON
admet-376	67	7	understanding	understanding	NOUN
admet-376	67	8	of	of	ADP
admet-376	67	9	the	the	DET
admet-376	67	10	nature	nature	NOUN
admet-376	67	11	and	and	CCONJ
admet-376	67	12	evolution	evolution	NOUN
admet-376	67	13	of	of	ADP
admet-376	67	14	human	human	ADJ
admet-376	67	15	drug	drug	NOUN
admet-376	67	16	transporters	transporter	NOUN
admet-376	67	17	.	.	PUNCT
admet-376	68	1	experimental	experimental	ADJ
admet-376	68	2	as	as	ADP
admet-376	68	3	previously	previously	ADV
admet-376	68	4	[	[	X
admet-376	68	5	22	22	NUM
admet-376	68	6	-	-	SYM
admet-376	68	7	24	24	NUM
admet-376	68	8	,	,	PUNCT
admet-376	68	9	115	115	NUM
admet-376	68	10	]	]	PUNCT
admet-376	68	11	,	,	PUNCT
admet-376	68	12	we	we	PRON
admet-376	68	13	used	use	VERB
admet-376	68	14	the	the	DET
admet-376	68	15	list	list	NOUN
admet-376	68	16	of	of	ADP
admet-376	68	17	1381	1381	NUM
admet-376	68	18	marketed	market	VERB
admet-376	68	19	drugs	drug	NOUN
admet-376	68	20	and	and	CCONJ
admet-376	68	21	1113	1113	NUM
admet-376	68	22	recon2	recon2	NOUN
admet-376	68	23	-	-	PUNCT
admet-376	68	24	based	base	VERB
admet-376	68	25	endogenous	endogenous	ADJ
admet-376	68	26	metabolites	metabolite	NOUN
admet-376	68	27	as	as	SCONJ
admet-376	68	28	provided	provide	VERB
admet-376	68	29	in	in	ADP
admet-376	68	30	the	the	DET
admet-376	68	31	supplementary	supplementary	ADJ
admet-376	68	32	information	information	NOUN
admet-376	68	33	to	to	ADP
admet-376	68	34	[	[	X
admet-376	68	35	22	22	NUM
admet-376	68	36	]	]	PUNCT
admet-376	68	37	.	.	PUNCT
admet-376	69	1	a	a	DET
admet-376	69	2	number	number	NOUN
admet-376	69	3	of	of	ADP
admet-376	69	4	natural	natural	ADJ
admet-376	69	5	products	product	NOUN
admet-376	69	6	and	and	CCONJ
admet-376	69	7	other	other	ADJ
admet-376	69	8	databases	database	NOUN
admet-376	69	9	exist	exist	VERB
admet-376	69	10	[	[	X
admet-376	69	11	116	116	NUM
admet-376	69	12	-	-	SYM
admet-376	69	13	121	121	NUM
admet-376	69	14	]	]	PUNCT
admet-376	69	15	.	.	PUNCT
admet-376	70	1	we	we	PRON
admet-376	70	2	have	have	AUX
admet-376	70	3	here	here	ADV
admet-376	70	4	used	use	VERB
admet-376	70	5	the	the	DET
admet-376	70	6	dataset	dataset	NOUN
admet-376	70	7	for	for	ADP
admet-376	70	8	measured	measure	VERB
admet-376	70	9	serum	serum	NOUN
admet-376	70	10	metabolites	metabolite	NOUN
admet-376	70	11	kindly	kindly	ADV
admet-376	70	12	provided	provide	VERB
admet-376	70	13	by	by	ADP
admet-376	70	14	prof	prof	PROPN
admet-376	70	15	david	david	PROPN
admet-376	70	16	wishart	wishart	PROPN
admet-376	70	17	and	and	CCONJ
admet-376	70	18	colleagues	colleague	NOUN
admet-376	70	19	[	[	X
admet-376	70	20	122	122	NUM
admet-376	70	21	]	]	PUNCT
admet-376	70	22	,	,	PUNCT
admet-376	70	23	but	but	CCONJ
admet-376	70	24	removed	remove	VERB
admet-376	70	25	all	all	DET
admet-376	70	26	substances	substance	NOUN
admet-376	70	27	marked	mark	VERB
admet-376	70	28	as	as	ADP
admet-376	70	29	drugs	drug	NOUN
admet-376	70	30	or	or	CCONJ
admet-376	70	31	that	that	PRON
admet-376	70	32	were	be	AUX
admet-376	70	33	in	in	ADP
admet-376	70	34	recon2	recon2	NOUN
admet-376	70	35	.	.	PUNCT
admet-376	71	1	in	in	ADP
admet-376	71	2	addition	addition	NOUN
admet-376	71	3	,	,	PUNCT
admet-376	71	4	where	where	SCONJ
admet-376	71	5	noted	note	VERB
admet-376	71	6	,	,	PUNCT
admet-376	71	7	we	we	PRON
admet-376	71	8	also	also	ADV
admet-376	71	9	studied	study	VERB
admet-376	71	10	datasets	dataset	NOUN
admet-376	71	11	such	such	ADJ
admet-376	71	12	as	as	ADP
admet-376	71	13	unpd	unpd	NOUN
admet-376	71	14	http://pkuxxj.pku.edu.cn/unpd/	http://pkuxxj.pku.edu.cn/unpd/	PROPN
admet-376	71	15	[	[	X
admet-376	71	16	123	123	NUM
admet-376	71	17	]	]	PUNCT
admet-376	71	18	and	and	CCONJ
admet-376	71	19	zinc	zinc	NOUN
admet-376	71	20	[	[	X
admet-376	71	21	124	124	NUM
admet-376	71	22	,	,	PUNCT
admet-376	71	23	125	125	NUM
admet-376	71	24	]	]	PUNCT
admet-376	71	25	.	.	PUNCT
admet-376	72	1	we	we	PRON
admet-376	72	2	also	also	ADV
admet-376	72	3	obtained	obtain	VERB
admet-376	72	4	a	a	DET
admet-376	72	5	license	license	NOUN
admet-376	72	6	for	for	ADP
admet-376	72	7	the	the	DET
admet-376	72	8	(	(	PUNCT
admet-376	72	9	commercial	commercial	ADJ
admet-376	72	10	)	)	PUNCT
admet-376	72	11	dictionary	dictionary	NOUN
admet-376	72	12	of	of	ADP
admet-376	72	13	natural	natural	ADJ
admet-376	72	14	products	product	NOUN
admet-376	72	15	[	[	X
admet-376	72	16	126	126	NUM
admet-376	72	17	]	]	PUNCT
admet-376	72	18	http://dnp.chemnetbase.com/intro/.	http://dnp.chemnetbase.com/intro/.	PRON
admet-376	72	19	all	all	DET
admet-376	72	20	comparisons	comparison	NOUN
admet-376	72	21	were	be	AUX
admet-376	72	22	done	do	VERB
admet-376	72	23	using	use	VERB
admet-376	72	24	knime	knime	NOUN
admet-376	72	25	-	-	PUNCT
admet-376	72	26	based	base	VERB
admet-376	72	27	workflows	workflow	NOUN
admet-376	72	28	(	(	PUNCT
admet-376	72	29	[	[	X
admet-376	72	30	127	127	NUM
admet-376	72	31	-	-	SYM
admet-376	72	32	129	129	NUM
admet-376	72	33	]	]	PUNCT
admet-376	72	34	and	and	CCONJ
admet-376	72	35	www.knime.org/	www.knime.org/	NOUN
admet-376	72	36	)	)	PUNCT
admet-376	72	37	,	,	PUNCT
admet-376	72	38	and	and	CCONJ
admet-376	72	39	in	in	ADP
admet-376	72	40	particular	particular	ADJ
admet-376	72	41	we	we	PRON
admet-376	72	42	made	make	VERB
admet-376	72	43	use	use	NOUN
admet-376	72	44	of	of	ADP
admet-376	72	45	the	the	DET
admet-376	72	46	rdkit	rdkit	ADJ
admet-376	72	47	nodes	node	NOUN
admet-376	72	48	[	[	X
admet-376	72	49	113	113	NUM
admet-376	72	50	,	,	PUNCT
admet-376	72	51	130	130	NUM
admet-376	72	52	]	]	PUNCT
admet-376	72	53	(	(	PUNCT
admet-376	72	54	http://rdkit.org/	http://rdkit.org/	NOUN
admet-376	72	55	)	)	PUNCT
admet-376	72	56	.	.	PUNCT
admet-376	73	1	results	result	NOUN
admet-376	73	2	and	and	CCONJ
admet-376	73	3	discussion	discussion	NOUN
admet-376	73	4	variance	variance	NOUN
admet-376	73	5	in	in	ADP
admet-376	73	6	‘	'	PUNCT
admet-376	73	7	similarity	similarity	NOUN
admet-376	73	8	’	'	PUNCT
admet-376	73	9	with	with	ADP
admet-376	73	10	different	different	ADJ
admet-376	73	11	fingerprint	fingerprint	NOUN
admet-376	73	12	encodings	encoding	NOUN
admet-376	73	13	leaving	leave	VERB
admet-376	73	14	aside	aside	ADV
admet-376	73	15	molecules	molecule	NOUN
admet-376	73	16	that	that	PRON
admet-376	73	17	are	be	AUX
admet-376	73	18	actually	actually	ADV
admet-376	73	19	both	both	CCONJ
admet-376	73	20	drugs	drug	NOUN
admet-376	73	21	and	and	CCONJ
admet-376	73	22	metabolites	metabolite	NOUN
admet-376	73	23	,	,	PUNCT
admet-376	73	24	some	some	DET
admet-376	73	25	drugs	drug	NOUN
admet-376	73	26	are	be	AUX
admet-376	73	27	clearly	clearly	ADV
admet-376	73	28	much	much	ADV
admet-376	73	29	more	more	ADV
admet-376	73	30	similar	similar	ADJ
admet-376	73	31	to	to	ADP
admet-376	73	32	one	one	NUM
admet-376	73	33	or	or	CCONJ
admet-376	73	34	more	more	ADV
admet-376	73	35	endogenous	endogenous	ADJ
admet-376	73	36	metabolites	metabolite	NOUN
admet-376	73	37	than	than	SCONJ
admet-376	73	38	are	be	AUX
admet-376	73	39	others	other	NOUN
admet-376	73	40	,	,	PUNCT
admet-376	73	41	and	and	CCONJ
admet-376	73	42	this	this	PRON
admet-376	73	43	is	be	AUX
admet-376	73	44	true	true	ADJ
admet-376	73	45	for	for	ADP
admet-376	73	46	a	a	DET
admet-376	73	47	variety	variety	NOUN
admet-376	73	48	of	of	ADP
admet-376	73	49	fingerprint	fingerprint	NOUN
admet-376	73	50	encodings	encoding	NOUN
admet-376	73	51	[	[	PUNCT
admet-376	73	52	22	22	NUM
admet-376	73	53	-	-	SYM
admet-376	73	54	24	24	NUM
admet-376	73	55	]	]	PUNCT
admet-376	73	56	as	as	SCONJ
admet-376	73	57	provided	provide	VERB
admet-376	73	58	via	via	ADP
admet-376	73	59	rdkit	rdkit	ADJ
admet-376	73	60	[	[	X
admet-376	73	61	113	113	NUM
admet-376	73	62	,	,	PUNCT
admet-376	73	63	130	130	NUM
admet-376	73	64	]	]	PUNCT
admet-376	73	65	.	.	PUNCT
admet-376	74	1	the	the	DET
admet-376	74	2	question	question	NOUN
admet-376	74	3	thus	thus	ADV
admet-376	74	4	arose	arise	VERB
admet-376	74	5	as	as	ADP
admet-376	74	6	to	to	ADP
admet-376	74	7	whether	whether	SCONJ
admet-376	74	8	these	these	DET
admet-376	74	9	similarities	similarity	NOUN
admet-376	74	10	extended	extend	VERB
admet-376	74	11	to	to	ADP
admet-376	74	12	the	the	DET
admet-376	74	13	actual	actual	ADJ
admet-376	74	14	rank	rank	NOUN
admet-376	74	15	orders	order	NOUN
admet-376	74	16	of	of	ADP
admet-376	74	17	the	the	DET
admet-376	74	18	drugs	drug	NOUN
admet-376	74	19	(	(	PUNCT
admet-376	74	20	with	with	ADP
admet-376	74	21	1	1	NUM
admet-376	74	22	always	always	ADV
admet-376	74	23	being	be	AUX
admet-376	74	24	the	the	DET
admet-376	74	25	drug	drug	NOUN
admet-376	74	26	most	most	ADV
admet-376	74	27	similar	similar	ADJ
admet-376	74	28	to	to	ADP
admet-376	74	29	an	an	DET
admet-376	74	30	endogenite	endogenite	NOUN
admet-376	74	31	)	)	PUNCT
admet-376	74	32	.	.	PUNCT
admet-376	75	1	in	in	ADP
admet-376	75	2	other	other	ADJ
admet-376	75	3	words	word	NOUN
admet-376	75	4	,	,	PUNCT
admet-376	75	5	was	be	AUX
admet-376	75	6	the	the	DET
admet-376	75	7	drug	drug	NOUN
admet-376	75	8	that	that	PRON
admet-376	75	9	was	be	AUX
admet-376	75	10	most	most	ADV
admet-376	75	11	similar	similar	ADJ
admet-376	75	12	to	to	ADP
admet-376	75	13	an	an	DET
admet-376	75	14	endogenite	endogenite	NOUN
admet-376	75	15	when	when	SCONJ
admet-376	75	16	these	these	PRON
admet-376	75	17	were	be	AUX
admet-376	75	18	represented	represent	VERB
admet-376	75	19	using	use	VERB
admet-376	75	20	the	the	DET
admet-376	75	21	maccs	maccs	NOUN
admet-376	75	22	encoding	encoding	NOUN
admet-376	75	23	also	also	ADV
admet-376	75	24	most	most	ADV
admet-376	75	25	similar	similar	ADJ
admet-376	75	26	with	with	ADP
admet-376	75	27	say	say	VERB
admet-376	75	28	the	the	DET
admet-376	75	29	atom	atom	NOUN
admet-376	75	30	pair	pair	NOUN
admet-376	75	31	encoding	encoding	NOUN
admet-376	75	32	?	?	PUNCT
admet-376	76	1	for	for	ADP
admet-376	76	2	ease	ease	NOUN
admet-376	76	3	of	of	ADP
admet-376	76	4	assessment	assessment	NOUN
admet-376	76	5	,	,	PUNCT
admet-376	76	6	figure	figure	NOUN
admet-376	76	7	1a	1a	PROPN
admet-376	76	8	recapitulates	recapitulate	VERB
admet-376	76	9	the	the	DET
admet-376	76	10	original	original	ADJ
admet-376	76	11	analysis	analysis	NOUN
admet-376	76	12	[	[	X
admet-376	76	13	22	22	NUM
admet-376	76	14	]	]	PUNCT
admet-376	76	15	(	(	PUNCT
admet-376	76	16	freely	freely	ADV
admet-376	76	17	available	available	ADJ
admet-376	76	18	under	under	ADP
admet-376	76	19	a	a	DET
admet-376	76	20	cc	cc	NOUN
admet-376	76	21	-	-	PUNCT
admet-376	76	22	by	by	ADP
admet-376	76	23	license	license	NOUN
admet-376	76	24	)	)	PUNCT
admet-376	76	25	.	.	PUNCT
admet-376	77	1	the	the	DET
admet-376	77	2	three	three	NUM
admet-376	77	3	encodings	encoding	NOUN
admet-376	77	4	that	that	PRON
admet-376	77	5	seemed	seem	VERB
admet-376	77	6	to	to	PART
admet-376	77	7	maximise	maximise	VERB
admet-376	77	8	the	the	DET
admet-376	77	9	endogenite	endogenite	NOUN
admet-376	77	10	-	-	PUNCT
admet-376	77	11	likeness	likeness	NOUN
admet-376	77	12	of	of	ADP
admet-376	77	13	marketed	market	VERB
admet-376	77	14	drugs	drug	NOUN
admet-376	77	15	in	in	ADP
admet-376	77	16	the	the	DET
admet-376	77	17	earlier	early	ADJ
admet-376	77	18	paper	paper	NOUN
admet-376	78	1	[	[	X
admet-376	78	2	22	22	NUM
admet-376	78	3	]	]	PUNCT
admet-376	78	4	were	be	AUX
admet-376	78	5	the	the	DET
admet-376	78	6	maccs	maccs	NOUN
admet-376	78	7	,	,	PUNCT
admet-376	78	8	layered	layered	ADJ
admet-376	78	9	and	and	CCONJ
admet-376	78	10	rdkit	rdkit	ADJ
admet-376	78	11	encodings	encoding	NOUN
admet-376	78	12	in	in	ADP
admet-376	78	13	rdkit	rdkit	NOUN
admet-376	78	14	.	.	PUNCT
admet-376	79	1	thus	thus	ADV
admet-376	79	2	figure	figure	VERB
admet-376	79	3	1b	1b	NUM
admet-376	79	4	and	and	CCONJ
admet-376	79	5	1c	1c	NUM
admet-376	79	6	show	show	NOUN
admet-376	79	7	,	,	PUNCT
admet-376	79	8	respectively	respectively	ADV
admet-376	79	9	,	,	PUNCT
admet-376	79	10	the	the	DET
admet-376	79	11	relative	relative	ADJ
admet-376	79	12	rank	rank	NOUN
admet-376	79	13	orders	order	NOUN
admet-376	79	14	of	of	ADP
admet-376	79	15	layered	layered	NOUN
admet-376	79	16	and	and	CCONJ
admet-376	79	17	rdkit	rdkit	ADJ
admet-376	79	18	vs	vs	ADP
admet-376	79	19	maccs	maccs	NOUN
admet-376	79	20	,	,	PUNCT
admet-376	79	21	all	all	PRON
admet-376	79	22	using	use	VERB
admet-376	79	23	tanimoto	tanimoto	NOUN
admet-376	79	24	as	as	ADP
admet-376	79	25	the	the	DET
admet-376	79	26	metric	metric	NOUN
admet-376	79	27	of	of	ADP
admet-376	79	28	similarity	similarity	NOUN
admet-376	79	29	.	.	PUNCT
admet-376	80	1	it	it	PRON
admet-376	80	2	is	be	AUX
admet-376	80	3	clear	clear	ADJ
admet-376	80	4	that	that	SCONJ
admet-376	80	5	while	while	SCONJ
admet-376	80	6	a	a	DET
admet-376	80	7	small	small	ADJ
admet-376	80	8	subset	subset	NOUN
admet-376	80	9	of	of	ADP
admet-376	80	10	the	the	DET
admet-376	80	11	most	most	ADV
admet-376	80	12	endogenite	endogenite	NOUN
admet-376	80	13	-	-	PUNCT
admet-376	80	14	like	like	ADJ
admet-376	80	15	drugs	drug	NOUN
admet-376	80	16	preserve	preserve	VERB
admet-376	80	17	their	their	PRON
admet-376	80	18	rank	rank	NOUN
admet-376	80	19	order	order	NOUN
admet-376	80	20	between	between	ADP
admet-376	80	21	encodings	encoding	NOUN
admet-376	80	22	,	,	PUNCT
admet-376	80	23	the	the	DET
admet-376	80	24	rank	rank	NOUN
admet-376	80	25	order	order	NOUN
admet-376	80	26	for	for	ADP
admet-376	80	27	the	the	DET
admet-376	80	28	vast	vast	ADJ
admet-376	80	29	majority	majority	NOUN
admet-376	80	30	depends	depend	VERB
admet-376	80	31	very	very	ADV
admet-376	80	32	strongly	strongly	ADV
admet-376	80	33	on	on	ADP
admet-376	80	34	the	the	DET
admet-376	80	35	encoding	encoding	NOUN
admet-376	80	36	used	use	VERB
admet-376	80	37	(	(	PUNCT
admet-376	80	38	cf	cf	NOUN
admet-376	80	39	.	.	PUNCT
admet-376	81	1	[	[	X
admet-376	81	2	113	113	NUM
admet-376	81	3	]	]	PUNCT
admet-376	81	4	)	)	PUNCT
admet-376	81	5	.	.	PUNCT
admet-376	82	1	also	also	ADV
admet-376	82	2	shown	show	VERB
admet-376	82	3	for	for	ADP
admet-376	82	4	layered	layered	ADJ
admet-376	82	5	and	and	CCONJ
admet-376	82	6	rdkit	rdkit	ADJ
admet-376	82	7	(	(	PUNCT
admet-376	82	8	figures	figure	NOUN
admet-376	82	9	1b	1b	NUM
admet-376	82	10	,	,	PUNCT
admet-376	82	11	1c	1c	NOUN
admet-376	82	12	)	)	PUNCT
admet-376	82	13	are	be	AUX
admet-376	82	14	the	the	DET
admet-376	82	15	names	name	NOUN
admet-376	82	16	of	of	ADP
admet-376	82	17	a	a	DET
admet-376	82	18	few	few	ADJ
admet-376	82	19	drugs	drug	NOUN
admet-376	82	20	for	for	ADP
admet-376	82	21	which	which	PRON
admet-376	82	22	the	the	DET
admet-376	82	23	differences	difference	NOUN
admet-376	82	24	in	in	ADP
admet-376	82	25	rank	rank	NOUN
admet-376	82	26	order	order	NOUN
admet-376	82	27	are	be	AUX
admet-376	82	28	most	most	ADV
admet-376	82	29	extreme	extreme	ADJ
admet-376	82	30	.	.	PUNCT
admet-376	83	1	the	the	DET
admet-376	83	2	same	same	ADJ
admet-376	83	3	kind	kind	NOUN
admet-376	83	4	of	of	ADP
admet-376	83	5	phenomena	phenomenon	NOUN
admet-376	83	6	are	be	AUX
admet-376	83	7	true	true	ADJ
admet-376	83	8	for	for	ADP
admet-376	83	9	torsion	torsion	NOUN
admet-376	83	10	vs	vs	ADP
admet-376	83	11	maccs	maccs	NOUN
admet-376	83	12	(	(	PUNCT
admet-376	83	13	figure	figure	NOUN
admet-376	83	14	1d	1d	NUM
admet-376	83	15	)	)	PUNCT
admet-376	83	16	and	and	CCONJ
admet-376	83	17	indeed	indeed	ADV
admet-376	83	18	for	for	ADP
admet-376	83	19	all	all	DET
admet-376	83	20	the	the	DET
admet-376	83	21	other	other	ADJ
admet-376	83	22	comparisons	comparison	NOUN
admet-376	83	23	tested	test	VERB
admet-376	83	24	(	(	PUNCT
admet-376	83	25	data	datum	NOUN
admet-376	83	26	not	not	PART
admet-376	83	27	shown	show	VERB
admet-376	83	28	,	,	PUNCT
admet-376	83	29	but	but	CCONJ
admet-376	83	30	all	all	PRON
admet-376	83	31	of	of	ADP
admet-376	83	32	these	these	DET
admet-376	83	33	data	datum	NOUN
admet-376	83	34	are	be	AUX
admet-376	83	35	provided	provide	VERB
admet-376	83	36	as	as	ADP
admet-376	83	37	a	a	DET
admet-376	83	38	spreadsheet	spreadsheet	NOUN
admet-376	83	39	via	via	ADP
admet-376	83	40	the	the	DET
admet-376	83	41	http://pkuxxj.pku.edu.cn/unpd/	http://pkuxxj.pku.edu.cn/unpd/	PROPN
admet-376	83	42	http://dnp.chemnetbase.com/intro/	http://dnp.chemnetbase.com/intro/	X
admet-376	83	43	http://www.knime.org/	http://www.knime.org/	NOUN
admet-376	83	44	http://rdkit.org/	http://rdkit.org/	PROPN
admet-376	83	45	admet	admet	PROPN
admet-376	83	46	&	&	CCONJ
admet-376	83	47	dmpk	dmpk	PROPN
admet-376	83	48	5(2	5(2	NUM
admet-376	83	49	)	)	PUNCT
admet-376	83	50	(	(	PUNCT
admet-376	83	51	2017	2017	NUM
admet-376	83	52	)	)	PUNCT
admet-376	83	53	85	85	NUM
admet-376	83	54	-	-	SYM
admet-376	83	55	125	125	NUM
admet-376	83	56	exogenous	exogenous	ADJ
admet-376	83	57	natural	natural	ADJ
admet-376	83	58	products	product	NOUN
admet-376	83	59	as	as	ADP
admet-376	83	60	‘	'	PUNCT
admet-376	83	61	natural	natural	ADJ
admet-376	83	62	’	'	PUNCT
admet-376	83	63	drug	drug	NOUN
admet-376	83	64	transporter	transporter	NOUN
admet-376	83	65	substrates	substrate	VERB
admet-376	83	66	doi	doi	NOUN
admet-376	83	67	:	:	PUNCT
admet-376	83	68	10.5599	10.5599	NUM
admet-376	83	69	/	/	SYM
admet-376	83	70	admet.5.2.376	admet.5.2.376	PROPN
admet-376	83	71	89	89	NUM
admet-376	83	72	supplementary	supplementary	ADJ
admet-376	83	73	information	information	NOUN
admet-376	83	74	(	(	PUNCT
admet-376	83	75	dvsmdrugranks_full_w_descriptors_hits_with_maccs_ts.xls	dvsmdrugranks_full_w_descriptors_hits_with_maccs_ts.xls	NOUN
admet-376	83	76	)	)	PUNCT
admet-376	83	77	)	)	PUNCT
admet-376	83	78	.	.	PUNCT
admet-376	84	1	overall	overall	ADV
admet-376	84	2	,	,	PUNCT
admet-376	84	3	while	while	SCONJ
admet-376	84	4	the	the	DET
admet-376	84	5	generation	generation	NOUN
admet-376	84	6	of	of	ADP
admet-376	84	7	fingerprints	fingerprint	NOUN
admet-376	84	8	is	be	AUX
admet-376	84	9	entirely	entirely	ADV
admet-376	84	10	deterministic	deterministic	ADJ
admet-376	84	11	,	,	PUNCT
admet-376	84	12	we	we	PRON
admet-376	84	13	could	could	AUX
admet-376	84	14	discern	discern	VERB
admet-376	84	15	no	no	DET
admet-376	84	16	real	real	ADJ
admet-376	84	17	molecular	molecular	ADJ
admet-376	84	18	properties	property	NOUN
admet-376	84	19	that	that	PRON
admet-376	84	20	would	would	AUX
admet-376	84	21	predict	predict	VERB
admet-376	84	22	which	which	PRON
admet-376	84	23	ts	ts	ADP
admet-376	84	24	values	value	NOUN
admet-376	84	25	for	for	ADP
admet-376	84	26	a	a	DET
admet-376	84	27	given	give	VERB
admet-376	84	28	drug	drug	NOUN
admet-376	84	29	would	would	AUX
admet-376	84	30	be	be	AUX
admet-376	84	31	‘	'	PUNCT
admet-376	84	32	high	high	ADJ
admet-376	84	33	’	'	PUNCT
admet-376	84	34	or	or	CCONJ
admet-376	84	35	‘	'	PUNCT
admet-376	84	36	low	low	ADJ
admet-376	84	37	’	'	PUNCT
admet-376	84	38	for	for	ADP
admet-376	84	39	the	the	DET
admet-376	84	40	set	set	NOUN
admet-376	84	41	of	of	ADP
admet-376	84	42	endogenites	endogenite	NOUN
admet-376	84	43	.	.	PUNCT
admet-376	85	1	this	this	PRON
admet-376	85	2	could	could	AUX
admet-376	85	3	be	be	AUX
admet-376	85	4	seen	see	VERB
admet-376	85	5	as	as	ADP
admet-376	85	6	giving	give	VERB
admet-376	85	7	weight	weight	NOUN
admet-376	85	8	to	to	PART
admet-376	85	9	view	view	VERB
admet-376	85	10	that	that	SCONJ
admet-376	85	11	each	each	PRON
admet-376	85	12	is	be	AUX
admet-376	85	13	of	of	ADP
admet-376	85	14	value	value	NOUN
admet-376	85	15	and	and	CCONJ
admet-376	85	16	might	might	AUX
admet-376	85	17	be	be	AUX
admet-376	85	18	used	use	VERB
admet-376	85	19	as	as	ADP
admet-376	85	20	required	require	VERB
admet-376	85	21	.	.	PUNCT
admet-376	86	1	we	we	PRON
admet-376	86	2	also	also	ADV
admet-376	86	3	compared	compare	VERB
admet-376	86	4	the	the	DET
admet-376	86	5	tversky	tversky	ADJ
admet-376	86	6	similarities	similarity	NOUN
admet-376	86	7	(	(	PUNCT
admet-376	86	8	=0.2	=0.2	ADJ
admet-376	86	9	,	,	PUNCT
admet-376	86	10	=0.8	=0.8	NOUN
admet-376	86	11	)	)	PUNCT
admet-376	86	12	(	(	PUNCT
admet-376	86	13	see	see	VERB
admet-376	86	14	[	[	X
admet-376	86	15	24	24	NUM
admet-376	86	16	,	,	PUNCT
admet-376	86	17	115	115	NUM
admet-376	86	18	]	]	PUNCT
admet-376	86	19	)	)	PUNCT
admet-376	86	20	for	for	ADP
admet-376	86	21	the	the	DET
admet-376	86	22	different	different	ADJ
admet-376	86	23	encodings	encoding	NOUN
admet-376	86	24	,	,	PUNCT
admet-376	86	25	with	with	ADP
admet-376	86	26	figure	figure	NOUN
admet-376	86	27	1e	1e	NOUN
admet-376	86	28	illustrating	illustrate	VERB
admet-376	86	29	its	its	PRON
admet-376	86	30	comparison	comparison	NOUN
admet-376	86	31	with	with	ADP
admet-376	86	32	the	the	DET
admet-376	86	33	rank	rank	NOUN
admet-376	86	34	-	-	PUNCT
admet-376	86	35	ordered	order	VERB
admet-376	86	36	tanimoto	tanimoto	NOUN
admet-376	86	37	similarity	similarity	NOUN
admet-376	86	38	for	for	ADP
admet-376	86	39	the	the	DET
admet-376	86	40	maccs	maccs	PROPN
admet-376	86	41	encoding	encoding	NOUN
admet-376	86	42	.	.	PUNCT
admet-376	87	1	it	it	PRON
admet-376	87	2	may	may	AUX
admet-376	87	3	again	again	ADV
admet-376	87	4	be	be	AUX
admet-376	87	5	concluded	conclude	VERB
admet-376	87	6	that	that	SCONJ
admet-376	87	7	while	while	SCONJ
admet-376	87	8	some	some	DET
admet-376	87	9	drugs	drug	NOUN
admet-376	87	10	appear	appear	VERB
admet-376	87	11	numerically	numerically	ADV
admet-376	87	12	similar	similar	ADJ
admet-376	87	13	to	to	ADP
admet-376	87	14	a	a	DET
admet-376	87	15	given	give	VERB
admet-376	87	16	metabolite	metabolite	NOUN
admet-376	87	17	under	under	ADP
admet-376	87	18	the	the	DET
admet-376	87	19	different	different	ADJ
admet-376	87	20	metrics	metric	NOUN
admet-376	87	21	,	,	PUNCT
admet-376	87	22	many	many	ADJ
admet-376	87	23	do	do	VERB
admet-376	87	24	not	not	PART
admet-376	87	25	.	.	PUNCT
admet-376	88	1	however	however	ADV
admet-376	88	2	,	,	PUNCT
admet-376	88	3	in	in	ADP
admet-376	88	4	this	this	DET
admet-376	88	5	case	case	NOUN
admet-376	88	6	the	the	DET
admet-376	88	7	correlation	correlation	NOUN
admet-376	88	8	(	(	PUNCT
admet-376	88	9	r2	r2	NOUN
admet-376	88	10	=	=	NOUN
admet-376	88	11	0.76	0.76	NUM
admet-376	88	12	)	)	PUNCT
admet-376	88	13	is	be	AUX
admet-376	88	14	considerably	considerably	ADV
admet-376	88	15	better	well	ADJ
admet-376	88	16	than	than	ADP
admet-376	88	17	that	that	PRON
admet-376	88	18	for	for	ADP
admet-376	88	19	comparisons	comparison	NOUN
admet-376	88	20	of	of	ADP
admet-376	88	21	the	the	DET
admet-376	88	22	different	different	ADJ
admet-376	88	23	encodings	encoding	NOUN
admet-376	88	24	.	.	PUNCT
admet-376	89	1	finally	finally	ADV
admet-376	89	2	,	,	PUNCT
admet-376	89	3	we	we	PRON
admet-376	89	4	illustrate	illustrate	VERB
admet-376	89	5	several	several	ADJ
admet-376	89	6	correlation	correlation	NOUN
admet-376	89	7	plots	plot	NOUN
admet-376	89	8	together	together	ADV
admet-376	89	9	(	(	PUNCT
admet-376	89	10	figure	figure	NOUN
admet-376	89	11	1f	1f	NUM
admet-376	89	12	)	)	PUNCT
admet-376	89	13	.	.	PUNCT
admet-376	90	1	figure	figure	NOUN
admet-376	90	2	1	1	NUM
admet-376	90	3	.	.	PUNCT
admet-376	90	4	continued	continue	VERB
admet-376	90	5	on	on	ADP
admet-376	90	6	the	the	DET
admet-376	90	7	next	next	ADJ
admet-376	90	8	page	page	NOUN
admet-376	90	9	…	…	PUNCT
admet-376	90	10	o'hagan	o'hagan	PROPN
admet-376	90	11	&	&	CCONJ
admet-376	90	12	kell	kell	PROPN
admet-376	90	13	admet	admet	PROPN
admet-376	90	14	&	&	CCONJ
admet-376	90	15	dmpk	dmpk	PROPN
admet-376	90	16	5(2	5(2	NUM
admet-376	90	17	)	)	PUNCT
admet-376	90	18	(	(	PUNCT
admet-376	90	19	2017	2017	NUM
admet-376	90	20	)	)	PUNCT
admet-376	90	21	85	85	NUM
admet-376	90	22	-	-	SYM
admet-376	90	23	125	125	NUM
admet-376	90	24	90	90	NUM
admet-376	90	25	figure	figure	NOUN
admet-376	90	26	1	1	NUM
admet-376	90	27	.	.	PUNCT
admet-376	91	1	…	…	PUNCT
admet-376	91	2	continued	continue	VERB
admet-376	91	3	on	on	ADP
admet-376	91	4	the	the	DET
admet-376	91	5	next	next	ADJ
admet-376	91	6	page	page	NOUN
admet-376	91	7	…	…	PUNCT
admet-376	91	8	admet	admet	PROPN
admet-376	91	9	&	&	CCONJ
admet-376	91	10	dmpk	dmpk	PROPN
admet-376	91	11	5(2	5(2	NUM
admet-376	91	12	)	)	PUNCT
admet-376	91	13	(	(	PUNCT
admet-376	91	14	2017	2017	NUM
admet-376	91	15	)	)	PUNCT
admet-376	91	16	85	85	NUM
admet-376	91	17	-	-	SYM
admet-376	91	18	125	125	NUM
admet-376	91	19	exogenous	exogenous	ADJ
admet-376	91	20	natural	natural	ADJ
admet-376	91	21	products	product	NOUN
admet-376	91	22	as	as	ADP
admet-376	91	23	‘	'	PUNCT
admet-376	91	24	natural	natural	ADJ
admet-376	91	25	’	'	PUNCT
admet-376	91	26	drug	drug	NOUN
admet-376	91	27	transporter	transporter	NOUN
admet-376	91	28	substrates	substrate	VERB
admet-376	91	29	doi	doi	NOUN
admet-376	91	30	:	:	PUNCT
admet-376	91	31	10.5599	10.5599	NUM
admet-376	91	32	/	/	SYM
admet-376	91	33	admet.5.2.376	admet.5.2.376	PROPN
admet-376	91	34	91	91	NUM
admet-376	91	35	figure	figure	NOUN
admet-376	91	36	1	1	NUM
admet-376	91	37	.	.	PUNCT
admet-376	91	38	…	…	PUNCT
admet-376	91	39	continued	continue	VERB
admet-376	91	40	on	on	ADP
admet-376	91	41	the	the	DET
admet-376	91	42	next	next	ADJ
admet-376	91	43	page	page	NOUN
admet-376	91	44	…	…	PUNCT
admet-376	91	45	o'hagan	o'hagan	PROPN
admet-376	91	46	&	&	CCONJ
admet-376	91	47	kell	kell	PROPN
admet-376	91	48	admet	admet	PROPN
admet-376	91	49	&	&	CCONJ
admet-376	91	50	dmpk	dmpk	PROPN
admet-376	91	51	5(2	5(2	NUM
admet-376	91	52	)	)	PUNCT
admet-376	91	53	(	(	PUNCT
admet-376	91	54	2017	2017	NUM
admet-376	91	55	)	)	PUNCT
admet-376	91	56	85	85	NUM
admet-376	91	57	-	-	SYM
admet-376	91	58	125	125	NUM
admet-376	91	59	92	92	NUM
admet-376	91	60	figure	figure	NOUN
admet-376	91	61	1	1	NUM
admet-376	91	62	.	.	PUNCT
admet-376	91	63	cumulative	cumulative	ADJ
admet-376	91	64	similarity	similarity	NOUN
admet-376	91	65	and	and	CCONJ
admet-376	91	66	rank	rank	NOUN
admet-376	91	67	order	order	NOUN
admet-376	91	68	of	of	ADP
admet-376	91	69	various	various	ADJ
admet-376	91	70	encodings	encoding	NOUN
admet-376	91	71	.	.	PUNCT
admet-376	92	1	a.	a.	PROPN
admet-376	92	2	cumulative	cumulative	PROPN
admet-376	92	3	rank	rank	NOUN
admet-376	92	4	order	order	NOUN
admet-376	92	5	(	(	PUNCT
admet-376	92	6	most	most	ADV
admet-376	92	7	similar	similar	ADJ
admet-376	92	8	on	on	ADP
admet-376	92	9	the	the	DET
admet-376	92	10	right	right	NOUN
admet-376	92	11	)	)	PUNCT
admet-376	92	12	of	of	ADP
admet-376	92	13	a	a	DET
admet-376	92	14	drug	drug	NOUN
admet-376	92	15	to	to	ADP
admet-376	92	16	its	its	PRON
admet-376	92	17	closest	close	ADJ
admet-376	92	18	endogenite	endogenite	NOUN
admet-376	92	19	for	for	ADP
admet-376	92	20	a	a	DET
admet-376	92	21	series	series	NOUN
admet-376	92	22	of	of	ADP
admet-376	92	23	encodings	encoding	NOUN
admet-376	92	24	,	,	PUNCT
admet-376	92	25	redrawn	redrawn	NOUN
admet-376	92	26	(	(	PUNCT
admet-376	92	27	under	under	ADP
admet-376	92	28	a	a	DET
admet-376	92	29	cc	cc	NOUN
admet-376	92	30	-	-	PUNCT
admet-376	92	31	by	by	ADP
admet-376	92	32	license	license	NOUN
admet-376	92	33	)	)	PUNCT
admet-376	92	34	from	from	ADP
admet-376	92	35	[	[	X
admet-376	92	36	22	22	NUM
admet-376	92	37	]	]	PUNCT
admet-376	92	38	.	.	PUNCT
admet-376	93	1	for	for	ADP
admet-376	93	2	the	the	DET
admet-376	93	3	other	other	ADJ
admet-376	93	4	parts	part	NOUN
admet-376	93	5	of	of	ADP
admet-376	93	6	this	this	DET
admet-376	93	7	figure	figure	NOUN
admet-376	93	8	,	,	PUNCT
admet-376	93	9	each	each	DET
admet-376	93	10	symbol	symbol	NOUN
admet-376	93	11	represents	represent	VERB
admet-376	93	12	the	the	DET
admet-376	93	13	rank	rank	NOUN
admet-376	93	14	order	order	NOUN
admet-376	93	15	of	of	ADP
admet-376	93	16	the	the	DET
admet-376	93	17	encodings	encoding	NOUN
admet-376	93	18	specified	specify	VERB
admet-376	93	19	.	.	PUNCT
admet-376	94	1	in	in	ADP
admet-376	94	2	addition	addition	NOUN
admet-376	94	3	,	,	PUNCT
admet-376	94	4	although	although	SCONJ
admet-376	94	5	there	there	PRON
admet-376	94	6	were	be	VERB
admet-376	94	7	no	no	DET
admet-376	94	8	observable	observable	ADJ
admet-376	94	9	trends	trend	NOUN
admet-376	94	10	,	,	PUNCT
admet-376	94	11	symbol	symbol	NOUN
admet-376	94	12	size	size	NOUN
admet-376	94	13	encodes	encode	NOUN
admet-376	94	14	total	total	ADJ
admet-376	94	15	polar	polar	ADJ
admet-376	94	16	surface	surface	NOUN
admet-376	94	17	area	area	NOUN
admet-376	94	18	,	,	PUNCT
admet-376	94	19	while	while	SCONJ
admet-376	94	20	colour	colour	NOUN
admet-376	94	21	encodes	encode	VERB
admet-376	94	22	the	the	DET
admet-376	94	23	number	number	NOUN
admet-376	94	24	of	of	ADP
admet-376	94	25	aromatic	aromatic	ADJ
admet-376	94	26	rings	ring	NOUN
admet-376	94	27	in	in	ADP
admet-376	94	28	the	the	DET
admet-376	94	29	drug	drug	NOUN
admet-376	94	30	(	(	PUNCT
admet-376	94	31	0	0	NUM
admet-376	94	32	blue	blue	ADJ
admet-376	94	33	,	,	PUNCT
admet-376	94	34	1	1	NUM
admet-376	94	35	emerald	emerald	NOUN
admet-376	94	36	,	,	PUNCT
admet-376	94	37	2	2	NUM
admet-376	94	38	red	red	ADJ
admet-376	94	39	,	,	PUNCT
admet-376	94	40	3	3	NUM
admet-376	94	41	yellow	yellow	ADJ
admet-376	94	42	,	,	PUNCT
admet-376	94	43	4	4	NUM
admet-376	94	44	lilac	lilac	NOUN
admet-376	94	45	,	,	PUNCT
admet-376	94	46	5	5	NUM
admet-376	94	47	orange	orange	ADJ
admet-376	94	48	,	,	PUNCT
admet-376	94	49	6	6	NUM
admet-376	94	50	sapphire	sapphire	NOUN
admet-376	94	51	,	,	PUNCT
admet-376	94	52	8	8	NUM
admet-376	94	53	cyan	cyan	NOUN
admet-376	94	54	)	)	PUNCT
admet-376	94	55	,	,	PUNCT
admet-376	94	56	and	and	CCONJ
admet-376	94	57	these	these	PRON
admet-376	94	58	can	can	AUX
admet-376	94	59	help	help	VERB
admet-376	94	60	to	to	PART
admet-376	94	61	identify	identify	VERB
admet-376	94	62	individual	individual	ADJ
admet-376	94	63	molecules	molecule	NOUN
admet-376	94	64	in	in	ADP
admet-376	94	65	different	different	ADJ
admet-376	94	66	encodings	encoding	NOUN
admet-376	94	67	.	.	PUNCT
admet-376	95	1	b.	b.	PROPN
admet-376	95	2	layered	layer	VERB
admet-376	95	3	vs	vs	ADP
admet-376	95	4	maccs	maccs	PROPN
admet-376	95	5	encoding	encoding	PROPN
admet-376	95	6	,	,	PUNCT
admet-376	95	7	tanimoto	tanimoto	PROPN
admet-376	95	8	similarities	similarity	NOUN
admet-376	95	9	,	,	PUNCT
admet-376	95	10	r	r	NOUN
admet-376	95	11	2	2	NUM
admet-376	95	12	=	=	SYM
admet-376	95	13	0.38	0.38	NUM
admet-376	95	14	.	.	PUNCT
admet-376	96	1	c.	c.	PROPN
admet-376	96	2	rdkit	rdkit	PROPN
admet-376	96	3	vs	vs	ADP
admet-376	96	4	maccs	maccs	PROPN
admet-376	96	5	encoding	encoding	PROPN
admet-376	96	6	,	,	PUNCT
admet-376	96	7	tanimoto	tanimoto	PROPN
admet-376	96	8	similarities	similarity	NOUN
admet-376	96	9	,	,	PUNCT
admet-376	96	10	r	r	NOUN
admet-376	96	11	2	2	NUM
admet-376	96	12	=	=	SYM
admet-376	96	13	0.16	0.16	NUM
admet-376	96	14	.	.	PUNCT
admet-376	97	1	d.	d.	PROPN
admet-376	97	2	torsion	torsion	PROPN
admet-376	97	3	vs	vs	ADP
admet-376	97	4	maccs	maccs	PROPN
admet-376	97	5	encoding	encoding	PROPN
admet-376	97	6	,	,	PUNCT
admet-376	97	7	tanimoto	tanimoto	PROPN
admet-376	97	8	similarities	similarity	NOUN
admet-376	97	9	,	,	PUNCT
admet-376	97	10	r	r	NOUN
admet-376	97	11	2	2	NUM
admet-376	97	12	=	=	SYM
admet-376	97	13	0.20	0.20	NUM
admet-376	97	14	.	.	PUNCT
admet-376	98	1	e.	e.	PROPN
admet-376	98	2	tversky	tversky	PROPN
admet-376	98	3	(	(	PUNCT
admet-376	98	4	=0.2	=0.2	ADJ
admet-376	98	5	,	,	PUNCT
admet-376	98	6	=0.8	=0.8	NOUN
admet-376	98	7	)	)	PUNCT
admet-376	98	8	similarity	similarity	NOUN
admet-376	98	9	vs	vs	ADP
admet-376	98	10	tanimoto	tanimoto	PROPN
admet-376	98	11	similarity	similarity	PROPN
admet-376	98	12	for	for	ADP
admet-376	98	13	maccs	maccs	PROPN
admet-376	98	14	encoding	encoding	NOUN
admet-376	98	15	.	.	PUNCT
admet-376	99	1	r	r	NOUN
admet-376	99	2	2	2	NUM
admet-376	99	3	=	=	SYM
admet-376	99	4	0.76	0.76	NUM
admet-376	99	5	.	.	PUNCT
admet-376	100	1	f.	f.	PROPN
admet-376	100	2	plot	plot	PROPN
admet-376	100	3	of	of	ADP
admet-376	100	4	multiple	multiple	ADJ
admet-376	100	5	comparisons	comparison	NOUN
admet-376	100	6	(	(	PUNCT
admet-376	100	7	blue	blue	ADJ
admet-376	100	8	best	good	ADJ
admet-376	100	9	linear	linear	ADJ
admet-376	100	10	fit	fit	ADJ
admet-376	100	11	,	,	PUNCT
admet-376	100	12	red	red	ADJ
admet-376	100	13	best	good	ADJ
admet-376	100	14	loess	loess	NOUN
admet-376	100	15	fit	fit	PROPN
admet-376	100	16	)	)	PUNCT
admet-376	100	17	.	.	PUNCT
admet-376	101	1	to	to	PART
admet-376	101	2	encapsulate	encapsulate	VERB
admet-376	101	3	and	and	CCONJ
admet-376	101	4	to	to	PART
admet-376	101	5	summarise	summarise	VERB
admet-376	101	6	all	all	PRON
admet-376	101	7	of	of	ADP
admet-376	101	8	the	the	DET
admet-376	101	9	rdkit	rdkit	ADJ
admet-376	101	10	encodings	encoding	NOUN
admet-376	101	11	used	use	VERB
admet-376	101	12	in	in	ADP
admet-376	101	13	one	one	NUM
admet-376	101	14	graph	graph	NOUN
admet-376	101	15	,	,	PUNCT
admet-376	101	16	we	we	PRON
admet-376	101	17	compared	compare	VERB
admet-376	101	18	the	the	DET
admet-376	101	19	sum	sum	NOUN
admet-376	101	20	of	of	ADP
admet-376	101	21	all	all	DET
admet-376	101	22	the	the	DET
admet-376	101	23	rank	rank	NOUN
admet-376	101	24	orders	order	NOUN
admet-376	101	25	with	with	ADP
admet-376	101	26	their	their	PRON
admet-376	101	27	range	range	NOUN
admet-376	101	28	(	(	PUNCT
admet-376	101	29	figure	figure	NOUN
admet-376	101	30	2a	2a	NUM
admet-376	101	31	)	)	PUNCT
admet-376	101	32	.	.	PUNCT
admet-376	102	1	thus	thus	ADV
admet-376	102	2	those	those	PRON
admet-376	102	3	at	at	ADP
admet-376	102	4	the	the	DET
admet-376	102	5	top	top	ADJ
admet-376	102	6	right	right	NOUN
admet-376	102	7	of	of	ADP
admet-376	102	8	the	the	DET
admet-376	102	9	plot	plot	NOUN
admet-376	102	10	(	(	PUNCT
admet-376	102	11	figure	figure	NOUN
admet-376	102	12	2b	2b	NOUN
admet-376	102	13	)	)	PUNCT
admet-376	102	14	are	be	AUX
admet-376	102	15	those	those	DET
admet-376	102	16	drugs	drug	NOUN
admet-376	102	17	that	that	PRON
admet-376	102	18	are	be	AUX
admet-376	102	19	reliably	reliably	ADV
admet-376	102	20	of	of	ADP
admet-376	102	21	high	high	ADJ
admet-376	102	22	rank	rank	NOUN
admet-376	102	23	order	order	NOUN
admet-376	102	24	(	(	PUNCT
admet-376	102	25	most	most	ADV
admet-376	102	26	similar	similar	ADJ
admet-376	102	27	)	)	PUNCT
admet-376	102	28	whatever	whatever	PRON
admet-376	102	29	the	the	DET
admet-376	102	30	encoding	encoding	NOUN
admet-376	102	31	;	;	PUNCT
admet-376	102	32	there	there	PRON
admet-376	102	33	are	be	VERB
admet-376	102	34	only	only	ADV
admet-376	102	35	44	44	NUM
admet-376	102	36	where	where	SCONJ
admet-376	102	37	the	the	DET
admet-376	102	38	cut	cut	NOUN
admet-376	102	39	-	-	PUNCT
admet-376	102	40	off	off	NOUN
admet-376	102	41	was	be	AUX
admet-376	102	42	(	(	PUNCT
admet-376	102	43	somewhat	somewhat	ADV
admet-376	102	44	arbitrarily	arbitrarily	ADV
admet-376	102	45	)	)	PUNCT
admet-376	102	46	drawn	draw	VERB
admet-376	102	47	.	.	PUNCT
admet-376	103	1	similarly	similarly	ADV
admet-376	103	2	,	,	PUNCT
admet-376	103	3	a	a	DET
admet-376	103	4	small	small	ADJ
admet-376	103	5	subset	subset	NOUN
admet-376	103	6	are	be	AUX
admet-376	103	7	reliably	reliably	ADV
admet-376	103	8	of	of	ADP
admet-376	103	9	low	low	ADJ
admet-376	103	10	rank	rank	NOUN
admet-376	103	11	order	order	NOUN
admet-376	103	12	whatever	whatever	PRON
admet-376	103	13	the	the	DET
admet-376	103	14	encoding	encoding	NOUN
admet-376	103	15	(	(	PUNCT
admet-376	103	16	and	and	CCONJ
admet-376	103	17	include	include	VERB
admet-376	103	18	in	in	ADP
admet-376	103	19	particular	particular	ADJ
admet-376	103	20	‘	'	PUNCT
admet-376	103	21	drugs	drug	NOUN
admet-376	103	22	’	'	PUNCT
admet-376	103	23	such	such	ADJ
admet-376	103	24	as	as	ADP
admet-376	103	25	fluorinated	fluorinate	VERB
admet-376	103	26	inhalational	inhalational	ADJ
admet-376	103	27	anaesthetics	anaesthetic	NOUN
admet-376	103	28	that	that	PRON
admet-376	103	29	are	be	AUX
admet-376	103	30	clearly	clearly	ADV
admet-376	103	31	very	very	ADV
admet-376	103	32	far	far	ADV
admet-376	103	33	from	from	ADP
admet-376	103	34	endogenites	endogenite	NOUN
admet-376	103	35	)	)	PUNCT
admet-376	103	36	(	(	PUNCT
admet-376	103	37	figure	figure	NOUN
admet-376	103	38	2b	2b	NOUN
admet-376	103	39	)	)	PUNCT
admet-376	103	40	.	.	PUNCT
admet-376	104	1	another	another	DET
admet-376	104	2	subset	subset	NOUN
admet-376	104	3	(	(	PUNCT
admet-376	104	4	arbitrarily	arbitrarily	ADV
admet-376	104	5	picked	pick	VERB
admet-376	104	6	and	and	CCONJ
admet-376	104	7	illustrated	illustrate	VERB
admet-376	104	8	in	in	ADP
admet-376	104	9	figure	figure	NOUN
admet-376	104	10	2c	2c	NUM
admet-376	104	11	)	)	PUNCT
admet-376	104	12	contains	contain	VERB
admet-376	104	13	drugs	drug	NOUN
admet-376	104	14	that	that	PRON
admet-376	104	15	are	be	AUX
admet-376	104	16	mainly	mainly	ADV
admet-376	104	17	not	not	PART
admet-376	104	18	seen	see	VERB
admet-376	104	19	as	as	ADP
admet-376	104	20	very	very	ADV
admet-376	104	21	endogenite	endogenite	NOUN
admet-376	104	22	-	-	PUNCT
admet-376	104	23	like	like	ADJ
admet-376	104	24	except	except	SCONJ
admet-376	104	25	in	in	ADP
admet-376	104	26	one	one	NUM
admet-376	104	27	or	or	CCONJ
admet-376	104	28	two	two	NUM
admet-376	104	29	encodings	encoding	NOUN
admet-376	104	30	.	.	PUNCT
admet-376	105	1	however	however	ADV
admet-376	105	2	,	,	PUNCT
admet-376	105	3	it	it	PRON
admet-376	105	4	is	be	AUX
admet-376	105	5	obvious	obvious	ADJ
admet-376	105	6	that	that	SCONJ
admet-376	105	7	for	for	ADP
admet-376	105	8	the	the	DET
admet-376	105	9	vast	vast	ADJ
admet-376	105	10	majority	majority	NOUN
admet-376	105	11	of	of	ADP
admet-376	105	12	other	other	ADJ
admet-376	105	13	drugs	drug	NOUN
admet-376	105	14	the	the	DET
admet-376	105	15	rank	rank	NOUN
admet-376	105	16	order	order	NOUN
admet-376	105	17	(	(	PUNCT
admet-376	105	18	and	and	CCONJ
admet-376	105	19	hence	hence	ADV
admet-376	105	20	endogenite	endogenite	NOUN
admet-376	105	21	-	-	PUNCT
admet-376	105	22	likeness	likeness	NOUN
admet-376	105	23	)	)	PUNCT
admet-376	105	24	depends	depend	VERB
admet-376	105	25	very	very	ADV
admet-376	105	26	strongly	strongly	ADV
admet-376	105	27	upon	upon	SCONJ
admet-376	105	28	the	the	DET
admet-376	105	29	exact	exact	ADJ
admet-376	105	30	encoding	encoding	NOUN
admet-376	105	31	used	use	VERB
admet-376	105	32	.	.	PUNCT
admet-376	106	1	for	for	ADP
admet-376	106	2	these	these	PRON
admet-376	106	3	,	,	PUNCT
admet-376	106	4	endogenite	endogenite	NOUN
admet-376	106	5	-	-	PUNCT
admet-376	106	6	likeness	likeness	NOUN
admet-376	106	7	is	be	AUX
admet-376	106	8	not	not	PART
admet-376	106	9	therefore	therefore	ADV
admet-376	106	10	a	a	DET
admet-376	106	11	property	property	NOUN
admet-376	106	12	of	of	ADP
admet-376	106	13	the	the	DET
admet-376	106	14	drug	drug	NOUN
admet-376	106	15	per	per	X
admet-376	106	16	se	se	X
admet-376	106	17	but	but	CCONJ
admet-376	106	18	additionally	additionally	ADV
admet-376	106	19	(	(	PUNCT
admet-376	106	20	even	even	ADV
admet-376	106	21	particularly	particularly	ADV
admet-376	106	22	)	)	PUNCT
admet-376	106	23	of	of	ADP
admet-376	106	24	its	its	PRON
admet-376	106	25	encoding	encoding	NOUN
admet-376	106	26	into	into	ADP
admet-376	106	27	whichever	whichever	DET
admet-376	106	28	fingerprint	fingerprint	NOUN
admet-376	106	29	is	be	AUX
admet-376	106	30	chosen	choose	VERB
admet-376	106	31	.	.	PUNCT
admet-376	107	1	by	by	ADP
admet-376	107	2	contrast	contrast	NOUN
admet-376	107	3	,	,	PUNCT
admet-376	107	4	the	the	DET
admet-376	107	5	top	top	ADJ
admet-376	107	6	10	10	NUM
admet-376	107	7	%	%	NOUN
admet-376	107	8	or	or	CCONJ
admet-376	107	9	so	so	ADV
admet-376	107	10	of	of	ADP
admet-376	107	11	drugs	drug	NOUN
admet-376	107	12	,	,	PUNCT
admet-376	107	13	that	that	PRON
admet-376	107	14	are	be	AUX
admet-376	107	15	within	within	ADP
admet-376	107	16	a	a	DET
admet-376	107	17	maccs	maccs	PROPN
admet-376	107	18	tanimoto	tanimoto	PROPN
admet-376	107	19	similarity	similarity	PROPN
admet-376	107	20	of	of	ADP
admet-376	107	21	~0.8	~0.8	NOUN
admet-376	107	22	to	to	PART
admet-376	107	23	at	at	ADV
admet-376	107	24	least	least	ADV
admet-376	107	25	one	one	NUM
admet-376	107	26	endogenite	endogenite	NOUN
admet-376	107	27	,	,	PUNCT
admet-376	107	28	are	be	AUX
admet-376	107	29	relatively	relatively	ADV
admet-376	107	30	robust	robust	ADJ
admet-376	107	31	to	to	ADP
admet-376	107	32	the	the	DET
admet-376	107	33	different	different	ADJ
admet-376	107	34	encodings	encoding	NOUN
admet-376	107	35	(	(	PUNCT
admet-376	107	36	figure	figure	NOUN
admet-376	107	37	2d	2d	NOUN
admet-376	107	38	)	)	PUNCT
admet-376	107	39	,	,	PUNCT
admet-376	107	40	and	and	CCONJ
admet-376	107	41	one	one	PRON
admet-376	107	42	could	could	AUX
admet-376	107	43	argue	argue	VERB
admet-376	107	44	that	that	SCONJ
admet-376	107	45	this	this	DET
admet-376	107	46	relative	relative	ADJ
admet-376	107	47	independence	independence	NOUN
admet-376	107	48	from	from	ADP
admet-376	107	49	the	the	DET
admet-376	107	50	nature	nature	NOUN
admet-376	107	51	of	of	ADP
admet-376	107	52	the	the	DET
admet-376	107	53	encoding	encoding	NOUN
admet-376	107	54	does	do	AUX
admet-376	107	55	seem	seem	VERB
admet-376	107	56	to	to	PART
admet-376	107	57	be	be	AUX
admet-376	107	58	a	a	DET
admet-376	107	59	good	good	ADJ
admet-376	107	60	metric	metric	NOUN
admet-376	107	61	of	of	ADP
admet-376	107	62	“	"	PUNCT
admet-376	107	63	similarity	similarity	NOUN
admet-376	107	64	”	"	PUNCT
admet-376	107	65	.	.	PUNCT
admet-376	108	1	although	although	SCONJ
admet-376	108	2	this	this	PRON
admet-376	108	3	is	be	AUX
admet-376	108	4	something	something	PRON
admet-376	108	5	of	of	ADP
admet-376	108	6	a	a	DET
admet-376	108	7	self	self	NOUN
admet-376	108	8	-	-	PUNCT
admet-376	108	9	fulfilling	fulfil	VERB
admet-376	108	10	prophecy	prophecy	NOUN
admet-376	108	11	,	,	PUNCT
admet-376	108	12	inspection	inspection	NOUN
admet-376	108	13	of	of	ADP
admet-376	108	14	those	those	DET
admet-376	108	15	drugs	drug	NOUN
admet-376	108	16	also	also	ADV
admet-376	108	17	clearly	clearly	ADV
admet-376	108	18	does	do	AUX
admet-376	108	19	show	show	VERB
admet-376	108	20	a	a	DET
admet-376	108	21	admet	admet	NOUN
admet-376	108	22	&	&	CCONJ
admet-376	108	23	dmpk	dmpk	PROPN
admet-376	108	24	5(2	5(2	NUM
admet-376	108	25	)	)	PUNCT
admet-376	108	26	(	(	PUNCT
admet-376	108	27	2017	2017	NUM
admet-376	108	28	)	)	PUNCT
admet-376	108	29	85	85	NUM
admet-376	108	30	-	-	SYM
admet-376	108	31	125	125	NUM
admet-376	108	32	exogenous	exogenous	ADJ
admet-376	108	33	natural	natural	ADJ
admet-376	108	34	products	product	NOUN
admet-376	108	35	as	as	ADP
admet-376	108	36	‘	'	PUNCT
admet-376	108	37	natural	natural	ADJ
admet-376	108	38	’	'	PUNCT
admet-376	108	39	drug	drug	NOUN
admet-376	108	40	transporter	transporter	NOUN
admet-376	108	41	substrates	substrate	VERB
admet-376	108	42	doi	doi	NOUN
admet-376	108	43	:	:	PUNCT
admet-376	108	44	10.5599	10.5599	NUM
admet-376	108	45	/	/	SYM
admet-376	108	46	admet.5.2.376	admet.5.2.376	PROPN
admet-376	108	47	93	93	NUM
admet-376	108	48	metabolite	metabolite	NOUN
admet-376	108	49	-	-	PUNCT
admet-376	108	50	likeness	likeness	NOUN
admet-376	108	51	,	,	PUNCT
admet-376	108	52	especially	especially	ADV
admet-376	108	53	to	to	ADP
admet-376	108	54	endogenites	endogenite	NOUN
admet-376	108	55	such	such	ADJ
admet-376	108	56	as	as	ADP
admet-376	108	57	nucleobases	nucleobase	NOUN
admet-376	108	58	and	and	CCONJ
admet-376	108	59	sterols	sterol	NOUN
admet-376	108	60	(	(	PUNCT
admet-376	108	61	figure	figure	NOUN
admet-376	108	62	2e	2e	NUM
admet-376	108	63	)	)	PUNCT
admet-376	108	64	.	.	PUNCT
admet-376	109	1	in	in	ADP
admet-376	109	2	a	a	DET
admet-376	109	3	similar	similar	ADJ
admet-376	109	4	vein	vein	NOUN
admet-376	109	5	,	,	PUNCT
admet-376	109	6	although	although	SCONJ
admet-376	109	7	individual	individual	ADJ
admet-376	109	8	encodings	encoding	NOUN
admet-376	109	9	can	can	AUX
admet-376	109	10	vary	vary	VERB
admet-376	109	11	significantly	significantly	ADV
admet-376	109	12	,	,	PUNCT
admet-376	109	13	there	there	PRON
admet-376	109	14	is	be	VERB
admet-376	109	15	a	a	DET
admet-376	109	16	good	good	ADJ
admet-376	109	17	correlation	correlation	NOUN
admet-376	109	18	between	between	ADP
admet-376	109	19	the	the	DET
admet-376	109	20	average	average	ADJ
admet-376	109	21	tanimoto	tanimoto	PROPN
admet-376	109	22	similarity	similarity	NOUN
admet-376	109	23	(	(	PUNCT
admet-376	109	24	for	for	ADP
admet-376	109	25	the	the	DET
admet-376	109	26	morgan	morgan	PROPN
admet-376	109	27	,	,	PUNCT
admet-376	109	28	featmorgan	featmorgan	NOUN
admet-376	109	29	,	,	PUNCT
admet-376	109	30	atompair	atompair	NOUN
admet-376	109	31	,	,	PUNCT
admet-376	109	32	torsion	torsion	NOUN
admet-376	109	33	,	,	PUNCT
admet-376	109	34	rdkit	rdkit	NOUN
admet-376	109	35	,	,	PUNCT
admet-376	109	36	avalon	avalon	PROPN
admet-376	109	37	,	,	PUNCT
admet-376	109	38	layered	layer	VERB
admet-376	109	39	,	,	PUNCT
admet-376	109	40	maccs	maccs	NOUN
admet-376	109	41	and	and	CCONJ
admet-376	109	42	pattern	pattern	NOUN
admet-376	109	43	encodings	encoding	NOUN
admet-376	109	44	in	in	ADP
admet-376	109	45	rdkit	rdkit	NOUN
admet-376	109	46	)	)	PUNCT
admet-376	109	47	and	and	CCONJ
admet-376	109	48	the	the	DET
admet-376	109	49	drugs	drug	NOUN
admet-376	109	50	that	that	PRON
admet-376	109	51	have	have	VERB
admet-376	109	52	a	a	DET
admet-376	109	53	tanimoto	tanimoto	NOUN
admet-376	109	54	similarity	similarity	NOUN
admet-376	109	55	≥	≥	NUM
admet-376	109	56	0.8	0.8	NUM
admet-376	109	57	in	in	ADP
admet-376	109	58	the	the	DET
admet-376	109	59	maccs	maccs	NOUN
admet-376	109	60	encoding	encoding	NOUN
admet-376	109	61	(	(	PUNCT
admet-376	109	62	our	our	PRON
admet-376	109	63	standard	standard	ADJ
admet-376	109	64	benchmark	benchmark	NOUN
admet-376	109	65	)	)	PUNCT
admet-376	109	66	(	(	PUNCT
admet-376	109	67	figure	figure	NOUN
admet-376	109	68	2f	2f	NUM
admet-376	109	69	)	)	PUNCT
admet-376	109	70	.	.	PUNCT
admet-376	110	1	in	in	ADP
admet-376	110	2	figure	figure	NOUN
admet-376	110	3	2f	2f	NOUN
admet-376	110	4	,	,	PUNCT
admet-376	110	5	the	the	DET
admet-376	110	6	overall	overall	ADJ
admet-376	110	7	correlation	correlation	NOUN
admet-376	110	8	(	(	PUNCT
admet-376	110	9	r2	r2	PROPN
admet-376	110	10	)	)	PUNCT
admet-376	110	11	=	=	SYM
admet-376	110	12	0.77	0.77	NUM
admet-376	110	13	(	(	PUNCT
admet-376	110	14	slope	slope	NOUN
admet-376	110	15	=	=	SYM
admet-376	110	16	0.75	0.75	NUM
admet-376	110	17	)	)	PUNCT
admet-376	110	18	,	,	PUNCT
admet-376	110	19	and	and	CCONJ
admet-376	110	20	the	the	DET
admet-376	110	21	variance	variance	NOUN
admet-376	110	22	is	be	AUX
admet-376	110	23	much	much	ADV
admet-376	110	24	less	less	ADJ
admet-376	110	25	than	than	ADP
admet-376	110	26	that	that	PRON
admet-376	110	27	of	of	ADP
admet-376	110	28	the	the	DET
admet-376	110	29	rank	rank	NOUN
admet-376	110	30	order	order	NOUN
admet-376	110	31	.	.	PUNCT
admet-376	111	1	choosing	choose	VERB
admet-376	111	2	the	the	DET
admet-376	111	3	closest	close	ADJ
admet-376	111	4	encoding	encoding	NOUN
admet-376	111	5	for	for	ADP
admet-376	111	6	each	each	DET
admet-376	111	7	comparison	comparison	NOUN
admet-376	111	8	inspection	inspection	NOUN
admet-376	111	9	of	of	ADP
admet-376	111	10	figures	figure	NOUN
admet-376	111	11	2a-2c	2a-2c	PROPN
admet-376	111	12	shows	show	VERB
admet-376	111	13	a	a	DET
admet-376	111	14	very	very	ADV
admet-376	111	15	considerable	considerable	ADJ
admet-376	111	16	range	range	NOUN
admet-376	111	17	for	for	ADP
admet-376	111	18	the	the	DET
admet-376	111	19	majority	majority	NOUN
admet-376	111	20	of	of	ADP
admet-376	111	21	molecules	molecule	NOUN
admet-376	111	22	,	,	PUNCT
admet-376	111	23	implying	imply	VERB
admet-376	111	24	that	that	SCONJ
admet-376	111	25	for	for	ADP
admet-376	111	26	each	each	DET
admet-376	111	27	molecule	molecule	NOUN
admet-376	111	28	there	there	PRON
admet-376	111	29	is	be	VERB
admet-376	111	30	at	at	ADV
admet-376	111	31	least	least	ADJ
admet-376	111	32	one	one	NUM
admet-376	111	33	encoding	encoding	NOUN
admet-376	111	34	that	that	PRON
admet-376	111	35	is	be	AUX
admet-376	111	36	seen	see	VERB
admet-376	111	37	as	as	ADP
admet-376	111	38	having	have	VERB
admet-376	111	39	an	an	DET
admet-376	111	40	especially	especially	ADV
admet-376	111	41	close	close	ADJ
admet-376	111	42	value	value	NOUN
admet-376	111	43	of	of	ADP
admet-376	111	44	the	the	DET
admet-376	111	45	tanimoto	tanimoto	NOUN
admet-376	111	46	similarity	similarity	NOUN
admet-376	111	47	for	for	ADP
admet-376	111	48	a	a	DET
admet-376	111	49	particular	particular	ADJ
admet-376	111	50	drug	drug	NOUN
admet-376	111	51	-	-	PUNCT
admet-376	111	52	endogenite	endogenite	NOUN
admet-376	111	53	pair	pair	NOUN
admet-376	111	54	.	.	PUNCT
admet-376	112	1	this	this	DET
admet-376	112	2	best	good	ADJ
admet-376	112	3	or	or	CCONJ
admet-376	112	4	largest	large	ADJ
admet-376	112	5	value	value	NOUN
admet-376	112	6	is	be	AUX
admet-376	112	7	here	here	ADV
admet-376	112	8	referred	refer	VERB
admet-376	112	9	to	to	ADP
admet-376	112	10	as	as	SCONJ
admet-376	112	11	the	the	DET
admet-376	112	12	take	take	NOUN
admet-376	112	13	your	your	PRON
admet-376	112	14	pick	pick	NOUN
admet-376	112	15	improved	improve	VERB
admet-376	112	16	cheminformatic	cheminformatic	ADJ
admet-376	112	17	analytical	analytical	ADJ
admet-376	112	18	likeness	likeness	NOUN
admet-376	112	19	or	or	CCONJ
admet-376	112	20	typical	typical	ADJ
admet-376	112	21	encoding	encoding	NOUN
admet-376	112	22	/	/	SYM
admet-376	112	23	similarity	similarity	NOUN
admet-376	112	24	.	.	PUNCT
admet-376	113	1	figure	figure	NOUN
admet-376	113	2	2	2	NUM
admet-376	113	3	g	g	NOUN
admet-376	113	4	shows	show	VERB
admet-376	113	5	a	a	DET
admet-376	113	6	heatmap	heatmap	NOUN
admet-376	113	7	of	of	ADP
admet-376	113	8	the	the	DET
admet-376	113	9	similarities	similarity	NOUN
admet-376	113	10	of	of	ADP
admet-376	113	11	drugs	drug	NOUN
admet-376	113	12	and	and	CCONJ
admet-376	113	13	metabolites	metabolite	NOUN
admet-376	113	14	using	use	VERB
admet-376	113	15	the	the	DET
admet-376	113	16	typical	typical	ADJ
admet-376	113	17	encoding	encoding	NOUN
admet-376	113	18	(	(	PUNCT
admet-376	113	19	four	four	NUM
admet-376	113	20	molecules	molecule	NOUN
admet-376	113	21	are	be	AUX
admet-376	113	22	dropped	drop	VERB
admet-376	113	23	because	because	SCONJ
admet-376	113	24	of	of	ADP
admet-376	113	25	a	a	DET
admet-376	113	26	curiosity	curiosity	NOUN
admet-376	113	27	with	with	ADP
admet-376	113	28	the	the	DET
admet-376	113	29	torsion	torsion	NOUN
admet-376	113	30	encoding	encoding	NOUN
admet-376	113	31	)	)	PUNCT
admet-376	113	32	.	.	PUNCT
admet-376	114	1	under	under	ADP
admet-376	114	2	these	these	DET
admet-376	114	3	circumstances	circumstance	NOUN
admet-376	114	4	,	,	PUNCT
admet-376	114	5	the	the	DET
admet-376	114	6	percentages	percentage	NOUN
admet-376	114	7	of	of	ADP
admet-376	114	8	drugs	drug	NOUN
admet-376	114	9	having	have	VERB
admet-376	114	10	a	a	DET
admet-376	114	11	typical	typical	ADJ
admet-376	114	12	similarity	similarity	NOUN
admet-376	114	13	to	to	ADP
admet-376	114	14	an	an	DET
admet-376	114	15	endogenite	endogenite	NOUN
admet-376	114	16	of	of	ADP
admet-376	114	17	0.8	0.8	NUM
admet-376	114	18	,	,	PUNCT
admet-376	114	19	0.75	0.75	NUM
admet-376	114	20	and	and	CCONJ
admet-376	114	21	0.7	0.7	NUM
admet-376	114	22	are	be	AUX
admet-376	114	23	,	,	PUNCT
admet-376	114	24	respectively	respectively	ADV
admet-376	114	25	,	,	PUNCT
admet-376	114	26	45	45	NUM
admet-376	114	27	%	%	NOUN
admet-376	114	28	,	,	PUNCT
admet-376	114	29	66	66	NUM
admet-376	114	30	%	%	NOUN
admet-376	114	31	and	and	CCONJ
admet-376	114	32	88	88	NUM
admet-376	114	33	%	%	NOUN
admet-376	114	34	,	,	PUNCT
admet-376	114	35	as	as	SCONJ
admet-376	114	36	may	may	AUX
admet-376	114	37	also	also	ADV
admet-376	114	38	be	be	AUX
admet-376	114	39	observed	observe	VERB
admet-376	114	40	in	in	ADP
admet-376	114	41	the	the	DET
admet-376	114	42	cumulative	cumulative	ADJ
admet-376	114	43	plot	plot	NOUN
admet-376	114	44	of	of	ADP
admet-376	114	45	figure	figure	NOUN
admet-376	114	46	2	2	NUM
admet-376	114	47	g	g	NOUN
admet-376	114	48	shown	show	VERB
admet-376	114	49	in	in	ADP
admet-376	114	50	figure	figure	NOUN
admet-376	114	51	2h	2h	NUM
admet-376	114	52	.	.	PUNCT
admet-376	115	1	finally	finally	ADV
admet-376	115	2	,	,	PUNCT
admet-376	115	3	figure	figure	NOUN
admet-376	115	4	2i	2i	NOUN
admet-376	115	5	shows	show	VERB
admet-376	115	6	evidence	evidence	NOUN
admet-376	115	7	that	that	SCONJ
admet-376	115	8	a	a	DET
admet-376	115	9	suitable	suitable	ADJ
admet-376	115	10	cut	cut	NOUN
admet-376	115	11	-	-	PUNCT
admet-376	115	12	off	off	ADP
admet-376	115	13	value	value	NOUN
admet-376	115	14	of	of	ADP
admet-376	115	15	ts	ts	NOUN
admet-376	115	16	with	with	ADP
admet-376	115	17	a	a	DET
admet-376	115	18	standard	standard	ADJ
admet-376	115	19	encoding	encoding	NOUN
admet-376	115	20	for	for	ADP
admet-376	115	21	‘	'	PUNCT
admet-376	115	22	genuine	genuine	ADJ
admet-376	115	23	similarity	similarity	NOUN
admet-376	115	24	’	'	PUNCT
admet-376	115	25	is	be	AUX
admet-376	115	26	in	in	ADP
admet-376	115	27	the	the	DET
admet-376	115	28	range	range	NOUN
admet-376	115	29	0.75	0.75	NUM
admet-376	115	30	-	-	SYM
admet-376	115	31	0.8	0.8	NUM
admet-376	115	32	.	.	PUNCT
admet-376	116	1	use	use	NOUN
admet-376	116	2	of	of	ADP
admet-376	116	3	the	the	DET
admet-376	116	4	maximum	maximum	ADJ
admet-376	116	5	common	common	ADJ
admet-376	116	6	substructure	substructure	NOUN
admet-376	116	7	another	another	DET
admet-376	116	8	means	mean	NOUN
admet-376	116	9	of	of	ADP
admet-376	116	10	comparing	compare	VERB
admet-376	116	11	structural	structural	ADJ
admet-376	116	12	similarities	similarity	NOUN
admet-376	116	13	(	(	PUNCT
admet-376	116	14	and	and	CCONJ
admet-376	116	15	hence	hence	ADV
admet-376	116	16	rank	rank	NOUN
admet-376	116	17	orders	order	NOUN
admet-376	116	18	)	)	PUNCT
admet-376	116	19	,	,	PUNCT
admet-376	116	20	and	and	CCONJ
admet-376	116	21	one	one	NUM
admet-376	116	22	that	that	PRON
admet-376	116	23	does	do	AUX
admet-376	116	24	not	not	PART
admet-376	116	25	depend	depend	VERB
admet-376	116	26	nearly	nearly	ADV
admet-376	116	27	as	as	ADV
admet-376	116	28	much	much	ADJ
admet-376	116	29	(	(	PUNCT
admet-376	116	30	but	but	CCONJ
admet-376	116	31	see	see	VERB
admet-376	116	32	[	[	X
admet-376	116	33	131	131	NUM
admet-376	116	34	]	]	PUNCT
admet-376	116	35	)	)	PUNCT
admet-376	116	36	on	on	ADP
admet-376	116	37	the	the	DET
admet-376	116	38	fingerprint	fingerprint	NOUN
admet-376	116	39	encoding	encoding	NOUN
admet-376	116	40	used	use	VERB
admet-376	116	41	,	,	PUNCT
admet-376	116	42	is	be	AUX
admet-376	116	43	according	accord	VERB
admet-376	116	44	to	to	ADP
admet-376	116	45	the	the	DET
admet-376	116	46	size	size	NOUN
admet-376	116	47	of	of	ADP
admet-376	116	48	their	their	PRON
admet-376	116	49	maximum	maximum	ADJ
admet-376	116	50	common	common	ADJ
admet-376	116	51	substructure	substructure	NOUN
admet-376	116	52	(	(	PUNCT
admet-376	116	53	mcs	mcs	NOUN
admet-376	116	54	)	)	PUNCT
admet-376	116	55	.	.	PUNCT
admet-376	117	1	as	as	ADP
admet-376	117	2	before	before	ADP
admet-376	117	3	[	[	X
admet-376	117	4	24	24	NUM
admet-376	117	5	]	]	PUNCT
admet-376	117	6	,	,	PUNCT
admet-376	117	7	we	we	PRON
admet-376	117	8	have	have	AUX
admet-376	117	9	here	here	ADV
admet-376	117	10	done	do	VERB
admet-376	117	11	this	this	PRON
admet-376	117	12	using	use	VERB
admet-376	117	13	a	a	DET
admet-376	117	14	series	series	NOUN
admet-376	117	15	of	of	ADP
admet-376	117	16	values	value	NOUN
admet-376	117	17	of	of	ADP
admet-376	117	18	the	the	DET
admet-376	117	19	tversky	tversky	ADJ
admet-376	117	20	similarity	similarity	NOUN
admet-376	117	21	,	,	PUNCT
admet-376	117	22	varying	vary	VERB
admet-376	117	23	the	the	DET
admet-376	117	24	tversky	tversky	ADJ
admet-376	117	25	similarity	similarity	NOUN
admet-376	117	26	parameters	parameter	NOUN
admet-376	117	27	(	(	PUNCT
admet-376	117	28	and	and	NOUN
admet-376	117	29			NOUN
admet-376	117	30	)	)	PUNCT
admet-376	117	31	such	such	ADJ
admet-376	117	32	that	that	SCONJ
admet-376	117	33	their	their	PRON
admet-376	117	34	sum	sum	NOUN
admet-376	117	35	was	be	AUX
admet-376	117	36	either	either	CCONJ
admet-376	117	37	1	1	NUM
admet-376	117	38	(	(	PUNCT
admet-376	117	39	figure	figure	NOUN
admet-376	117	40	3a	3a	NUM
admet-376	117	41	)	)	PUNCT
admet-376	117	42	or	or	CCONJ
admet-376	117	43	2	2	NUM
admet-376	117	44	(	(	PUNCT
admet-376	117	45	figure	figure	NOUN
admet-376	117	46	3b	3b	NUM
admet-376	117	47	)	)	PUNCT
admet-376	117	48	.	.	PUNCT
admet-376	118	1	since	since	SCONJ
admet-376	118	2	the	the	DET
admet-376	118	3	encoding	encoding	NOUN
admet-376	118	4	is	be	AUX
admet-376	118	5	the	the	DET
admet-376	118	6	same	same	ADJ
admet-376	118	7	,	,	PUNCT
admet-376	118	8	the	the	DET
admet-376	118	9	correlations	correlation	NOUN
admet-376	118	10	between	between	ADP
admet-376	118	11	the	the	DET
admet-376	118	12	rank	rank	NOUN
admet-376	118	13	orders	order	NOUN
admet-376	118	14	for	for	ADP
admet-376	118	15	different	different	ADJ
admet-376	118	16	values	value	NOUN
admet-376	118	17	of	of	ADP
admet-376	118	18	and	and	NOUN
admet-376	118	19			PROPN
admet-376	118	20	are	be	AUX
admet-376	118	21	much	much	ADV
admet-376	118	22	higher	high	ADJ
admet-376	118	23	than	than	ADP
admet-376	118	24	for	for	ADP
admet-376	118	25	the	the	DET
admet-376	118	26	different	different	ADJ
admet-376	118	27	encodings	encoding	NOUN
admet-376	118	28	,	,	PUNCT
admet-376	118	29	with	with	ADP
admet-376	118	30	a	a	DET
admet-376	118	31	clear	clear	ADJ
admet-376	118	32	trend	trend	NOUN
admet-376	118	33	of	of	ADP
admet-376	118	34	similarities	similarity	NOUN
admet-376	118	35	being	be	AUX
admet-376	118	36	visible	visible	ADJ
admet-376	118	37	in	in	ADP
admet-376	118	38	the	the	DET
admet-376	118	39	violin	violin	NOUN
admet-376	118	40	plot	plot	NOUN
admet-376	118	41	of	of	ADP
admet-376	118	42	figure	figure	NOUN
admet-376	118	43	3c	3c	NUM
admet-376	118	44	.	.	PUNCT
admet-376	119	1	finally	finally	ADV
admet-376	119	2	,	,	PUNCT
admet-376	119	3	here	here	ADV
admet-376	119	4	,	,	PUNCT
admet-376	119	5	we	we	PRON
admet-376	119	6	illustrate	illustrate	VERB
admet-376	119	7	a	a	DET
admet-376	119	8	comparison	comparison	NOUN
admet-376	119	9	of	of	ADP
admet-376	119	10	the	the	DET
admet-376	119	11	mcs	mcs	PROPN
admet-376	119	12	with	with	ADP
admet-376	119	13	a	a	DET
admet-376	119	14	dice	dice	NOUN
admet-376	119	15	coefficient	coefficient	NOUN
admet-376	119	16	(	(	PUNCT
admet-376	119	17	=	=	NOUN
admet-376	119	18			NOUN
admet-376	119	19	=	=	NOUN
admet-376	119	20	0.5	0.5	NUM
admet-376	119	21	)	)	PUNCT
admet-376	119	22	and	and	CCONJ
admet-376	119	23	the	the	DET
admet-376	119	24	maccs_tanimoto	maccs_tanimoto	NOUN
admet-376	119	25	;	;	PUNCT
admet-376	119	26	again	again	ADV
admet-376	119	27	for	for	ADP
admet-376	119	28	the	the	DET
admet-376	119	29	drugs	drug	NOUN
admet-376	119	30	with	with	ADP
admet-376	119	31	the	the	DET
admet-376	119	32	highest	high	ADJ
admet-376	119	33	values	value	NOUN
admet-376	119	34	of	of	ADP
admet-376	119	35	ts	t	NOUN
admet-376	119	36	to	to	ADP
admet-376	119	37	a	a	DET
admet-376	119	38	metabolite	metabolite	NOUN
admet-376	119	39	(	(	PUNCT
admet-376	119	40	we	we	PRON
admet-376	119	41	illustrate	illustrate	VERB
admet-376	119	42	those	those	PRON
admet-376	119	43	over	over	ADP
admet-376	119	44	0.85	0.85	NUM
admet-376	119	45	this	this	DET
admet-376	119	46	time	time	NOUN
admet-376	119	47	)	)	PUNCT
admet-376	119	48	there	there	PRON
admet-376	119	49	is	be	VERB
admet-376	119	50	a	a	DET
admet-376	119	51	clear	clear	ADJ
admet-376	119	52	consistency	consistency	NOUN
admet-376	119	53	of	of	ADP
admet-376	119	54	the	the	DET
admet-376	119	55	metabolitelikeness	metabolitelikeness	NOUN
admet-376	119	56	of	of	ADP
admet-376	119	57	their	their	PRON
admet-376	119	58	fingerprint	fingerprint	NOUN
admet-376	119	59	-	-	PUNCT
admet-376	119	60	based	base	VERB
admet-376	119	61	maccs	maccs	NOUN
admet-376	119	62	encoding	encoding	NOUN
admet-376	119	63	and	and	CCONJ
admet-376	119	64	their	their	PRON
admet-376	119	65	mcs	mcs	NOUN
admet-376	119	66	with	with	ADP
admet-376	119	67	a	a	DET
admet-376	119	68	tversky	tversky	ADJ
admet-376	119	69	similarity	similarity	NOUN
admet-376	119	70	.	.	PUNCT
admet-376	120	1	o'hagan	o'hagan	PROPN
admet-376	120	2	&	&	CCONJ
admet-376	120	3	kell	kell	PROPN
admet-376	120	4	admet	admet	PROPN
admet-376	120	5	&	&	CCONJ
admet-376	120	6	dmpk	dmpk	PROPN
admet-376	120	7	5(2	5(2	NUM
admet-376	120	8	)	)	PUNCT
admet-376	120	9	(	(	PUNCT
admet-376	120	10	2017	2017	NUM
admet-376	120	11	)	)	PUNCT
admet-376	120	12	85	85	NUM
admet-376	120	13	-	-	SYM
admet-376	120	14	125	125	NUM
admet-376	120	15	94	94	NUM
admet-376	120	16	figure	figure	NOUN
admet-376	120	17	2	2	NUM
admet-376	120	18	.	.	NUM
admet-376	120	19	continued	continue	VERB
admet-376	120	20	on	on	ADP
admet-376	120	21	the	the	DET
admet-376	120	22	next	next	ADJ
admet-376	120	23	page	page	NOUN
admet-376	120	24	…	…	PUNCT
admet-376	120	25	admet	admet	PROPN
admet-376	120	26	&	&	CCONJ
admet-376	120	27	dmpk	dmpk	PROPN
admet-376	120	28	5(2	5(2	NUM
admet-376	120	29	)	)	PUNCT
admet-376	120	30	(	(	PUNCT
admet-376	120	31	2017	2017	NUM
admet-376	120	32	)	)	PUNCT
admet-376	120	33	85	85	NUM
admet-376	120	34	-	-	SYM
admet-376	120	35	125	125	NUM
admet-376	120	36	exogenous	exogenous	ADJ
admet-376	120	37	natural	natural	ADJ
admet-376	120	38	products	product	NOUN
admet-376	120	39	as	as	ADP
admet-376	120	40	‘	'	PUNCT
admet-376	120	41	natural	natural	ADJ
admet-376	120	42	’	'	PUNCT
admet-376	120	43	drug	drug	NOUN
admet-376	120	44	transporter	transporter	NOUN
admet-376	120	45	substrates	substrate	VERB
admet-376	120	46	doi	doi	NOUN
admet-376	120	47	:	:	PUNCT
admet-376	120	48	10.5599	10.5599	NUM
admet-376	120	49	/	/	SYM
admet-376	120	50	admet.5.2.376	admet.5.2.376	PROPN
admet-376	120	51	95	95	NUM
admet-376	120	52	figure	figure	NOUN
admet-376	120	53	2	2	NUM
admet-376	120	54	.	.	NUM
admet-376	120	55	…	…	PUNCT
admet-376	120	56	continued	continue	VERB
admet-376	120	57	on	on	ADP
admet-376	120	58	the	the	DET
admet-376	120	59	next	next	ADJ
admet-376	120	60	page	page	NOUN
admet-376	120	61	…	…	PUNCT
admet-376	120	62	o'hagan	o'hagan	PROPN
admet-376	120	63	&	&	CCONJ
admet-376	120	64	kell	kell	PROPN
admet-376	120	65	admet	admet	PROPN
admet-376	120	66	&	&	CCONJ
admet-376	120	67	dmpk	dmpk	PROPN
admet-376	120	68	5(2	5(2	NUM
admet-376	120	69	)	)	PUNCT
admet-376	120	70	(	(	PUNCT
admet-376	120	71	2017	2017	NUM
admet-376	120	72	)	)	PUNCT
admet-376	120	73	85	85	NUM
admet-376	120	74	-	-	SYM
admet-376	120	75	125	125	NUM
admet-376	120	76	96	96	NUM
admet-376	120	77	figure	figure	NOUN
admet-376	120	78	2	2	NUM
admet-376	120	79	.	.	NUM
admet-376	120	80	…	…	PUNCT
admet-376	120	81	continued	continue	VERB
admet-376	120	82	on	on	ADP
admet-376	120	83	the	the	DET
admet-376	120	84	next	next	ADJ
admet-376	120	85	page	page	NOUN
admet-376	120	86	…	…	PUNCT
admet-376	120	87	admet	admet	PROPN
admet-376	120	88	&	&	CCONJ
admet-376	120	89	dmpk	dmpk	PROPN
admet-376	120	90	5(2	5(2	NUM
admet-376	120	91	)	)	PUNCT
admet-376	120	92	(	(	PUNCT
admet-376	120	93	2017	2017	NUM
admet-376	120	94	)	)	PUNCT
admet-376	120	95	85	85	NUM
admet-376	120	96	-	-	SYM
admet-376	120	97	125	125	NUM
admet-376	120	98	exogenous	exogenous	ADJ
admet-376	120	99	natural	natural	ADJ
admet-376	120	100	products	product	NOUN
admet-376	120	101	as	as	ADP
admet-376	120	102	‘	'	PUNCT
admet-376	120	103	natural	natural	ADJ
admet-376	120	104	’	'	PUNCT
admet-376	120	105	drug	drug	NOUN
admet-376	120	106	transporter	transporter	NOUN
admet-376	120	107	substrates	substrate	VERB
admet-376	120	108	doi	doi	NOUN
admet-376	120	109	:	:	PUNCT
admet-376	120	110	10.5599	10.5599	NUM
admet-376	120	111	/	/	SYM
admet-376	120	112	admet.5.2.376	admet.5.2.376	PROPN
admet-376	120	113	97	97	NUM
admet-376	120	114	figure	figure	NOUN
admet-376	120	115	2	2	NUM
admet-376	120	116	.	.	NUM
admet-376	120	117	…	…	PUNCT
admet-376	120	118	continued	continue	VERB
admet-376	120	119	on	on	ADP
admet-376	120	120	the	the	DET
admet-376	120	121	next	next	ADJ
admet-376	120	122	page	page	NOUN
admet-376	120	123	…	…	PUNCT
admet-376	120	124	o'hagan	o'hagan	PROPN
admet-376	120	125	&	&	CCONJ
admet-376	120	126	kell	kell	PROPN
admet-376	120	127	admet	admet	PROPN
admet-376	120	128	&	&	CCONJ
admet-376	120	129	dmpk	dmpk	PROPN
admet-376	120	130	5(2	5(2	NUM
admet-376	120	131	)	)	PUNCT
admet-376	120	132	(	(	PUNCT
admet-376	120	133	2017	2017	NUM
admet-376	120	134	)	)	PUNCT
admet-376	120	135	85	85	NUM
admet-376	120	136	-	-	SYM
admet-376	120	137	125	125	NUM
admet-376	120	138	98	98	NUM
admet-376	120	139	figure	figure	NOUN
admet-376	120	140	2	2	NUM
admet-376	120	141	.	.	X
admet-376	120	142	relationship	relationship	NOUN
admet-376	120	143	between	between	ADP
admet-376	120	144	the	the	DET
admet-376	120	145	sum	sum	NOUN
admet-376	120	146	and	and	CCONJ
admet-376	120	147	the	the	DET
admet-376	120	148	range	range	NOUN
admet-376	120	149	of	of	ADP
admet-376	120	150	the	the	DET
admet-376	120	151	rank	rank	NOUN
admet-376	120	152	order	order	NOUN
admet-376	120	153	of	of	ADP
admet-376	120	154	the	the	DET
admet-376	120	155	different	different	ADJ
admet-376	120	156	encodings	encoding	NOUN
admet-376	120	157	.	.	PUNCT
admet-376	121	1	a.	a.	NOUN
admet-376	121	2	overview	overview	NOUN
admet-376	121	3	of	of	ADP
admet-376	121	4	the	the	DET
admet-376	121	5	shape	shape	NOUN
admet-376	121	6	of	of	ADP
admet-376	121	7	the	the	DET
admet-376	121	8	plot	plot	NOUN
admet-376	121	9	.	.	PUNCT
admet-376	122	1	b.	b.	NOUN
admet-376	122	2	names	name	NOUN
admet-376	122	3	of	of	ADP
admet-376	122	4	marketed	market	VERB
admet-376	122	5	drugs	drug	NOUN
admet-376	122	6	that	that	PRON
admet-376	122	7	are	be	AUX
admet-376	122	8	reliably	reliably	ADV
admet-376	122	9	most	most	ADV
admet-376	122	10	or	or	CCONJ
admet-376	122	11	least	least	ADJ
admet-376	122	12	like	like	ADP
admet-376	122	13	an	an	DET
admet-376	122	14	endogenite	endogenite	NOUN
admet-376	122	15	whatever	whatever	PRON
admet-376	122	16	the	the	DET
admet-376	122	17	encoding	encoding	NOUN
admet-376	122	18	.	.	PUNCT
admet-376	123	1	c.	c.	NOUN
admet-376	123	2	names	name	NOUN
admet-376	123	3	of	of	ADP
admet-376	123	4	drugs	drug	NOUN
admet-376	123	5	for	for	ADP
admet-376	123	6	which	which	PRON
admet-376	123	7	there	there	PRON
admet-376	123	8	is	be	VERB
admet-376	123	9	at	at	ADV
admet-376	123	10	least	least	ADJ
admet-376	123	11	one	one	NUM
admet-376	123	12	reasonably	reasonably	ADV
admet-376	123	13	high	high	ADJ
admet-376	123	14	rank	rank	NOUN
admet-376	123	15	order	order	NOUN
admet-376	123	16	but	but	CCONJ
admet-376	123	17	for	for	ADP
admet-376	123	18	which	which	PRON
admet-376	123	19	mostly	mostly	ADV
admet-376	123	20	they	they	PRON
admet-376	123	21	are	be	AUX
admet-376	123	22	not	not	PART
admet-376	123	23	encoded	encode	VERB
admet-376	123	24	as	as	ADP
admet-376	123	25	that	that	DET
admet-376	123	26	endogenite	endogenite	NOUN
admet-376	123	27	-	-	PUNCT
admet-376	123	28	like	like	ADJ
admet-376	123	29	.	.	PUNCT
admet-376	124	1	d.	d.	NOUN
admet-376	124	2	names	name	NOUN
admet-376	124	3	of	of	ADP
admet-376	124	4	top	top	ADJ
admet-376	124	5	138	138	NUM
admet-376	124	6	drugs	drug	NOUN
admet-376	124	7	(	(	PUNCT
admet-376	124	8	for	for	AUX
admet-376	124	9	which	which	PRON
admet-376	124	10	ts	ts	ADP
admet-376	124	11	≥	≥	NOUN
admet-376	124	12	0.8	0.8	NUM
admet-376	124	13	)	)	PUNCT
admet-376	124	14	judged	judge	VERB
admet-376	124	15	by	by	ADP
admet-376	124	16	maccs	maccs	PROPN
admet-376	124	17	similarity	similarity	NOUN
admet-376	124	18	in	in	ADP
admet-376	124	19	rank	rank	NOUN
admet-376	124	20	order	order	NOUN
admet-376	124	21	.	.	PUNCT
admet-376	125	1	e.	e.	PROPN
admet-376	125	2	names	name	NOUN
admet-376	125	3	of	of	ADP
admet-376	125	4	metabolites	metabolite	NOUN
admet-376	125	5	most	most	ADV
admet-376	125	6	similar	similar	ADJ
admet-376	125	7	to	to	ADP
admet-376	125	8	the	the	DET
admet-376	125	9	most	most	ADV
admet-376	125	10	metabolite	metabolite	NOUN
admet-376	125	11	-	-	PUNCT
admet-376	125	12	similar	similar	ADJ
admet-376	125	13	138	138	NUM
admet-376	125	14	drugs	drug	NOUN
admet-376	125	15	(	(	PUNCT
admet-376	125	16	for	for	ADP
admet-376	125	17	which	which	PRON
admet-376	125	18	ts	ts	ADP
admet-376	125	19	≥	≥	NOUN
admet-376	125	20	0.8	0.8	NUM
admet-376	125	21	)	)	PUNCT
admet-376	125	22	as	as	SCONJ
admet-376	125	23	judged	judge	VERB
admet-376	125	24	by	by	ADP
admet-376	125	25	maccs	maccs	PROPN
admet-376	125	26	similarity	similarity	PROPN
admet-376	125	27	.	.	PUNCT
admet-376	126	1	f.	f.	PROPN
admet-376	126	2	average	average	ADJ
admet-376	126	3	value	value	NOUN
admet-376	126	4	of	of	ADP
admet-376	126	5	ts	t	NOUN
admet-376	126	6	for	for	ADP
admet-376	126	7	multiple	multiple	ADJ
admet-376	126	8	encodings	encoding	NOUN
admet-376	126	9	vs	vs	ADP
admet-376	126	10	maccs	maccs	NOUN
admet-376	126	11	-	-	PUNCT
admet-376	126	12	encoded	encode	VERB
admet-376	126	13	tanimoto	tanimoto	NOUN
admet-376	126	14	similarity	similarity	NOUN
admet-376	126	15	.	.	PUNCT
admet-376	127	1	g.	g.	PROPN
admet-376	127	2	heatmap	heatmap	PROPN
admet-376	127	3	of	of	ADP
admet-376	127	4	similarities	similarity	NOUN
admet-376	127	5	of	of	ADP
admet-376	127	6	drugs	drug	NOUN
admet-376	127	7	vs	vs	ADP
admet-376	127	8	endogenites	endogenite	NOUN
admet-376	127	9	using	use	VERB
admet-376	127	10	the	the	DET
admet-376	127	11	typical	typical	ADJ
admet-376	127	12	encoding	encoding	NOUN
admet-376	127	13	.	.	PUNCT
admet-376	128	1	h.	h.	PROPN
admet-376	128	2	cumulative	cumulative	ADJ
admet-376	128	3	plot	plot	NOUN
admet-376	128	4	of	of	ADP
admet-376	128	5	heatmap	heatmap	NOUN
admet-376	128	6	data	datum	NOUN
admet-376	128	7	of	of	ADP
admet-376	128	8	g.	g.	PROPN
admet-376	128	9	i.	i.	PROPN
admet-376	128	10	evidence	evidence	NOUN
admet-376	128	11	that	that	SCONJ
admet-376	128	12	0.75	0.75	NUM
admet-376	128	13	-	-	SYM
admet-376	128	14	0.8	0.8	NUM
admet-376	128	15	is	be	AUX
admet-376	128	16	a	a	DET
admet-376	128	17	suitable	suitable	ADJ
admet-376	128	18	cut	cut	NOUN
admet-376	128	19	-	-	PUNCT
admet-376	128	20	off	off	ADP
admet-376	128	21	value	value	NOUN
admet-376	128	22	of	of	ADP
admet-376	128	23	ts	t	NOUN
admet-376	128	24	for	for	ADP
admet-376	128	25	‘	'	PUNCT
admet-376	128	26	genuine	genuine	ADJ
admet-376	128	27	’	'	PUNCT
admet-376	128	28	similarity	similarity	NOUN
admet-376	128	29	.	.	PUNCT
admet-376	129	1	assessment	assessment	NOUN
admet-376	129	2	of	of	ADP
admet-376	129	3	contribution	contribution	NOUN
admet-376	129	4	of	of	ADP
admet-376	129	5	descriptors	descriptor	NOUN
admet-376	129	6	to	to	ADP
admet-376	129	7	rank	rank	NOUN
admet-376	129	8	orders	order	NOUN
admet-376	129	9	using	use	VERB
admet-376	129	10	random	random	ADJ
admet-376	129	11	forest	forest	NOUN
admet-376	129	12	regression	regression	NOUN
admet-376	129	13	in	in	ADP
admet-376	129	14	order	order	NOUN
admet-376	129	15	to	to	PART
admet-376	129	16	understand	understand	VERB
admet-376	129	17	the	the	DET
admet-376	129	18	structural	structural	ADJ
admet-376	129	19	bases	basis	NOUN
admet-376	129	20	for	for	ADP
admet-376	129	21	some	some	PRON
admet-376	129	22	of	of	ADP
admet-376	129	23	the	the	DET
admet-376	129	24	rank	rank	NOUN
admet-376	129	25	orders	order	NOUN
admet-376	129	26	,	,	PUNCT
admet-376	129	27	we	we	PRON
admet-376	129	28	set	set	VERB
admet-376	129	29	up	up	ADP
admet-376	129	30	a	a	DET
admet-376	129	31	random	random	ADJ
admet-376	129	32	forest	forest	NOUN
admet-376	129	33	regression	regression	NOUN
admet-376	129	34	(	(	PUNCT
admet-376	129	35	see	see	VERB
admet-376	130	1	e.g.	e.g.	ADV
admet-376	130	2	[	[	X
admet-376	130	3	132	132	NUM
admet-376	130	4	,	,	PUNCT
admet-376	130	5	133	133	NUM
admet-376	130	6	]	]	PUNCT
admet-376	130	7	)	)	PUNCT
admet-376	130	8	to	to	PART
admet-376	130	9	assess	assess	VERB
admet-376	130	10	whether	whether	SCONJ
admet-376	130	11	we	we	PRON
admet-376	130	12	can	can	AUX
admet-376	130	13	indeed	indeed	ADV
admet-376	130	14	predict	predict	VERB
admet-376	130	15	the	the	DET
admet-376	130	16	rank	rank	NOUN
admet-376	130	17	of	of	ADP
admet-376	130	18	a	a	DET
admet-376	130	19	particular	particular	ADJ
admet-376	130	20	drug	drug	NOUN
admet-376	130	21	molecule	molecule	NOUN
admet-376	130	22	in	in	ADP
admet-376	130	23	terms	term	NOUN
admet-376	130	24	of	of	ADP
admet-376	130	25	the	the	DET
admet-376	130	26	tanimoto	tanimoto	NOUN
admet-376	130	27	similarity	similarity	NOUN
admet-376	130	28	of	of	ADP
admet-376	130	29	its	its	PRON
admet-376	130	30	closest	close	ADJ
admet-376	130	31	endogenous	endogenous	ADJ
admet-376	130	32	metabolite	metabolite	NOUN
admet-376	130	33	.	.	PUNCT
admet-376	131	1	as	as	SCONJ
admet-376	131	2	this	this	PRON
admet-376	131	3	is	be	AUX
admet-376	131	4	a	a	DET
admet-376	131	5	supervised	supervised	ADJ
admet-376	131	6	method	method	NOUN
admet-376	131	7	,	,	PUNCT
admet-376	131	8	we	we	PRON
admet-376	131	9	trained	train	VERB
admet-376	131	10	on	on	ADP
admet-376	131	11	a	a	DET
admet-376	131	12	subset	subset	NOUN
admet-376	131	13	of	of	ADP
admet-376	131	14	examples	example	NOUN
admet-376	131	15	to	to	PART
admet-376	131	16	see	see	VERB
admet-376	131	17	if	if	SCONJ
admet-376	131	18	we	we	PRON
admet-376	131	19	can	can	AUX
admet-376	131	20	predict	predict	VERB
admet-376	131	21	an	an	DET
admet-376	131	22	out	out	ADV
admet-376	131	23	-	-	PUNCT
admet-376	131	24	of	of	ADP
admet-376	131	25	-	-	PUNCT
admet-376	131	26	the	the	DET
admet-376	131	27	-	-	PUNCT
admet-376	131	28	box	box	NOUN
admet-376	131	29	set	set	NOUN
admet-376	131	30	.	.	PUNCT
admet-376	132	1	the	the	DET
admet-376	132	2	results	result	NOUN
admet-376	132	3	are	be	AUX
admet-376	132	4	shown	show	VERB
admet-376	132	5	in	in	ADP
admet-376	132	6	figure	figure	NOUN
admet-376	132	7	4a	4a	NOUN
admet-376	132	8	,	,	PUNCT
admet-376	132	9	indicating	indicate	VERB
admet-376	132	10	a	a	DET
admet-376	132	11	reasonable	reasonable	ADJ
admet-376	132	12	degree	degree	NOUN
admet-376	132	13	of	of	ADP
admet-376	132	14	success	success	NOUN
admet-376	132	15	.	.	PUNCT
admet-376	133	1	to	to	PART
admet-376	133	2	ensure	ensure	VERB
admet-376	133	3	that	that	SCONJ
admet-376	133	4	this	this	PRON
admet-376	133	5	was	be	AUX
admet-376	133	6	not	not	PART
admet-376	133	7	due	due	ADJ
admet-376	133	8	to	to	ADP
admet-376	133	9	any	any	DET
admet-376	133	10	kind	kind	NOUN
admet-376	133	11	of	of	ADP
admet-376	133	12	overtraining	overtraining	NOUN
admet-376	133	13	,	,	PUNCT
admet-376	133	14	we	we	PRON
admet-376	133	15	performed	perform	VERB
admet-376	133	16	target	target	NOUN
admet-376	133	17	permutation	permutation	NOUN
admet-376	133	18	i.e.	i.e.	X
admet-376	133	19	we	we	PRON
admet-376	133	20	randomised	randomise	VERB
admet-376	133	21	statistically	statistically	ADV
admet-376	133	22	the	the	DET
admet-376	133	23	values	value	NOUN
admet-376	133	24	of	of	ADP
admet-376	133	25	the	the	DET
admet-376	133	26	target	target	NOUN
admet-376	133	27	column	column	NOUN
admet-376	133	28	one	one	NUM
admet-376	133	29	thousand	thousand	NUM
admet-376	133	30	times	time	NOUN
admet-376	133	31	(	(	PUNCT
admet-376	133	32	data	datum	NOUN
admet-376	133	33	not	not	PART
admet-376	133	34	shown	show	VERB
admet-376	133	35	)	)	PUNCT
admet-376	133	36	.	.	PUNCT
admet-376	134	1	this	this	PRON
admet-376	134	2	served	serve	VERB
admet-376	134	3	to	to	PART
admet-376	134	4	break	break	VERB
admet-376	134	5	any	any	DET
admet-376	134	6	true	true	ADJ
admet-376	134	7	correlations	correlation	NOUN
admet-376	134	8	between	between	ADP
admet-376	134	9	the	the	DET
admet-376	134	10	features	feature	NOUN
admet-376	134	11	and	and	CCONJ
admet-376	134	12	the	the	DET
admet-376	134	13	targets	target	NOUN
admet-376	134	14	,	,	PUNCT
admet-376	134	15	showing	show	VERB
admet-376	134	16	that	that	SCONJ
admet-376	134	17	the	the	DET
admet-376	134	18	observed	observed	ADJ
admet-376	134	19	correlations	correlation	NOUN
admet-376	134	20	were	be	AUX
admet-376	134	21	indeed	indeed	ADV
admet-376	134	22	real	real	ADJ
admet-376	134	23	.	.	PUNCT
admet-376	135	1	figure	figure	VERB
admet-376	135	2	4b	4b	PROPN
admet-376	135	3	shows	show	VERB
admet-376	135	4	an	an	DET
admet-376	135	5	equivalent	equivalent	ADJ
admet-376	135	6	permutation	permutation	NOUN
admet-376	135	7	on	on	ADP
admet-376	135	8	the	the	DET
admet-376	135	9	features	feature	NOUN
admet-376	135	10	(	(	PUNCT
admet-376	135	11	i.e.	i.e.	X
admet-376	135	12	the	the	DET
admet-376	135	13	rdkit	rdkit	ADJ
admet-376	135	14	descriptors	descriptor	NOUN
admet-376	135	15	)	)	PUNCT
admet-376	135	16	,	,	PUNCT
admet-376	135	17	to	to	PART
admet-376	135	18	assess	assess	VERB
admet-376	135	19	those	those	PRON
admet-376	135	20	which	which	PRON
admet-376	135	21	most	most	ADV
admet-376	135	22	contributed	contribute	VERB
admet-376	135	23	to	to	ADP
admet-376	135	24	the	the	DET
admet-376	135	25	observed	observed	ADJ
admet-376	135	26	correlations	correlation	NOUN
admet-376	135	27	.	.	PUNCT
admet-376	136	1	finally	finally	ADV
admet-376	136	2	,	,	PUNCT
admet-376	136	3	figure	figure	VERB
admet-376	136	4	4c	4c	NOUN
admet-376	136	5	shows	show	VERB
admet-376	136	6	the	the	DET
admet-376	136	7	improvement	improvement	NOUN
admet-376	136	8	in	in	ADP
admet-376	136	9	correlation	correlation	NOUN
admet-376	136	10	that	that	PRON
admet-376	136	11	was	be	AUX
admet-376	136	12	observed	observe	VERB
admet-376	136	13	(	(	PUNCT
admet-376	136	14	in	in	ADP
admet-376	136	15	out	out	ADV
admet-376	136	16	-	-	PUNCT
admet-376	136	17	of	of	ADP
admet-376	136	18	-	-	PUNCT
admet-376	136	19	the	the	DET
admet-376	136	20	-	-	PUNCT
admet-376	136	21	box	box	NOUN
admet-376	136	22	data	datum	NOUN
admet-376	136	23	)	)	PUNCT
admet-376	136	24	as	as	SCONJ
admet-376	136	25	the	the	DET
admet-376	136	26	number	number	NOUN
admet-376	136	27	of	of	ADP
admet-376	136	28	features	feature	NOUN
admet-376	136	29	was	be	AUX
admet-376	136	30	increased	increase	VERB
admet-376	136	31	;	;	PUNCT
admet-376	136	32	evidently	evidently	ADV
admet-376	136	33	ten	ten	NUM
admet-376	136	34	features	feature	NOUN
admet-376	136	35	were	be	AUX
admet-376	136	36	sufficient	sufficient	ADJ
admet-376	136	37	to	to	PART
admet-376	136	38	achieve	achieve	VERB
admet-376	136	39	the	the	DET
admet-376	136	40	maximum	maximum	ADJ
admet-376	136	41	correlation	correlation	NOUN
admet-376	136	42	observed	observe	VERB
admet-376	136	43	.	.	PUNCT
admet-376	137	1	admet	admet	PROPN
admet-376	137	2	&	&	CCONJ
admet-376	137	3	dmpk	dmpk	PROPN
admet-376	137	4	5(2	5(2	NUM
admet-376	137	5	)	)	PUNCT
admet-376	137	6	(	(	PUNCT
admet-376	137	7	2017	2017	NUM
admet-376	137	8	)	)	PUNCT
admet-376	137	9	85	85	NUM
admet-376	137	10	-	-	SYM
admet-376	137	11	125	125	NUM
admet-376	137	12	exogenous	exogenous	ADJ
admet-376	137	13	natural	natural	ADJ
admet-376	137	14	products	product	NOUN
admet-376	137	15	as	as	ADP
admet-376	137	16	‘	'	PUNCT
admet-376	137	17	natural	natural	ADJ
admet-376	137	18	’	'	PUNCT
admet-376	137	19	drug	drug	NOUN
admet-376	137	20	transporter	transporter	NOUN
admet-376	137	21	substrates	substrate	VERB
admet-376	137	22	doi	doi	NOUN
admet-376	137	23	:	:	PUNCT
admet-376	137	24	10.5599	10.5599	NUM
admet-376	137	25	/	/	SYM
admet-376	137	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	137	27	99	99	NUM
admet-376	137	28	figure	figure	NOUN
admet-376	137	29	3	3	NUM
admet-376	137	30	.	.	PUNCT
admet-376	137	31	continued	continue	VERB
admet-376	137	32	on	on	ADP
admet-376	137	33	the	the	DET
admet-376	137	34	next	next	ADJ
admet-376	137	35	page	page	NOUN
admet-376	137	36	…	…	PUNCT
admet-376	137	37	o'hagan	o'hagan	PROPN
admet-376	137	38	&	&	CCONJ
admet-376	137	39	kell	kell	PROPN
admet-376	137	40	admet	admet	PROPN
admet-376	137	41	&	&	CCONJ
admet-376	137	42	dmpk	dmpk	PROPN
admet-376	137	43	5(2	5(2	NUM
admet-376	137	44	)	)	PUNCT
admet-376	137	45	(	(	PUNCT
admet-376	137	46	2017	2017	NUM
admet-376	137	47	)	)	PUNCT
admet-376	137	48	85	85	NUM
admet-376	137	49	-	-	SYM
admet-376	137	50	125	125	NUM
admet-376	137	51	100	100	NUM
admet-376	137	52	figure	figure	NOUN
admet-376	137	53	3	3	NUM
admet-376	137	54	.	.	NOUN
admet-376	137	55	rank	rank	NOUN
admet-376	137	56	order	order	NOUN
admet-376	137	57	of	of	ADP
admet-376	137	58	drug	drug	NOUN
admet-376	137	59	-	-	PUNCT
admet-376	137	60	endogenite	endogenite	NOUN
admet-376	137	61	similarities	similarity	NOUN
admet-376	137	62	as	as	SCONJ
admet-376	137	63	judged	judge	VERB
admet-376	137	64	by	by	ADP
admet-376	137	65	the	the	DET
admet-376	137	66	size	size	NOUN
admet-376	137	67	of	of	ADP
admet-376	137	68	their	their	PRON
admet-376	137	69	maximum	maximum	ADJ
admet-376	137	70	common	common	ADJ
admet-376	137	71	substructures	substructure	NOUN
admet-376	137	72	(	(	PUNCT
admet-376	137	73	mcs	mcs	NOUN
admet-376	137	74	)	)	PUNCT
admet-376	137	75	,	,	PUNCT
admet-376	137	76	for	for	ADP
admet-376	137	77	varying	vary	VERB
admet-376	137	78	values	value	NOUN
admet-376	137	79	of	of	ADP
admet-376	137	80	the	the	DET
admet-376	137	81	tversky	tversky	ADJ
admet-376	137	82	similarities	similarity	NOUN
admet-376	137	83	(	(	PUNCT
admet-376	137	84	and	and	PROPN
admet-376	137	85	)	)	PUNCT
admet-376	137	86	.	.	PUNCT
admet-376	138	1	a.	a.	NOUN
admet-376	138	2	sum	sum	NOUN
admet-376	138	3	of	of	ADP
admet-376	138	4	and=	and=	NOUN
admet-376	138	5	1	1	X
admet-376	138	6	.	.	X
admet-376	138	7	b.	b.	PROPN
admet-376	138	8	sum	sum	NOUN
admet-376	138	9	of	of	ADP
admet-376	138	10	and=	and=	NOUN
admet-376	138	11	2	2	X
admet-376	138	12	.	.	PUNCT
admet-376	138	13	c.	c.	NOUN
admet-376	138	14	distribution	distribution	NOUN
admet-376	138	15	of	of	ADP
admet-376	138	16	values	value	NOUN
admet-376	138	17	of	of	ADP
admet-376	138	18	the	the	DET
admet-376	138	19	mcs	mcs	NOUN
admet-376	138	20	for	for	ADP
admet-376	138	21	varying	vary	VERB
admet-376	138	22	values	value	NOUN
admet-376	138	23	of	of	ADP
admet-376	138	24	sum	sum	NOUN
admet-376	138	25	of	of	ADP
admet-376	138	26	andwhen	andwhen	NOUN
admet-376	138	27	their	their	PRON
admet-376	138	28	sum	sum	NOUN
admet-376	138	29	is	be	AUX
admet-376	138	30	2	2	NUM
admet-376	138	31	.	.	PUNCT
admet-376	138	32	d.	d.	PROPN
admet-376	138	33	mcs	mcs	PROPN
admet-376	138	34	dice	dice	PROPN
admet-376	138	35	coefficient	coefficient	NOUN
admet-376	138	36	against	against	ADP
admet-376	138	37	maccs	maccs	PROPN
admet-376	138	38	tanimoto	tanimoto	PROPN
admet-376	138	39	similarity	similarity	PROPN
admet-376	138	40	.	.	PUNCT
admet-376	139	1	admet	admet	PROPN
admet-376	139	2	&	&	CCONJ
admet-376	139	3	dmpk	dmpk	PROPN
admet-376	139	4	5(2	5(2	NUM
admet-376	139	5	)	)	PUNCT
admet-376	139	6	(	(	PUNCT
admet-376	139	7	2017	2017	NUM
admet-376	139	8	)	)	PUNCT
admet-376	139	9	85	85	NUM
admet-376	139	10	-	-	SYM
admet-376	139	11	125	125	NUM
admet-376	139	12	exogenous	exogenous	ADJ
admet-376	139	13	natural	natural	ADJ
admet-376	139	14	products	product	NOUN
admet-376	139	15	as	as	ADP
admet-376	139	16	‘	'	PUNCT
admet-376	139	17	natural	natural	ADJ
admet-376	139	18	’	'	PUNCT
admet-376	139	19	drug	drug	NOUN
admet-376	139	20	transporter	transporter	NOUN
admet-376	139	21	substrates	substrate	VERB
admet-376	139	22	doi	doi	NOUN
admet-376	139	23	:	:	PUNCT
admet-376	139	24	10.5599	10.5599	NUM
admet-376	139	25	/	/	SYM
admet-376	139	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	139	27	101	101	NUM
admet-376	139	28	figure	figure	NOUN
admet-376	139	29	4	4	NUM
admet-376	139	30	.	.	PUNCT
admet-376	139	31	continued	continue	VERB
admet-376	139	32	on	on	ADP
admet-376	139	33	the	the	DET
admet-376	139	34	next	next	ADJ
admet-376	139	35	page	page	NOUN
admet-376	139	36	…	…	PUNCT
admet-376	139	37	o'hagan	o'hagan	PROPN
admet-376	139	38	&	&	CCONJ
admet-376	139	39	kell	kell	PROPN
admet-376	139	40	admet	admet	PROPN
admet-376	139	41	&	&	CCONJ
admet-376	139	42	dmpk	dmpk	PROPN
admet-376	139	43	5(2	5(2	NUM
admet-376	139	44	)	)	PUNCT
admet-376	139	45	(	(	PUNCT
admet-376	139	46	2017	2017	NUM
admet-376	139	47	)	)	PUNCT
admet-376	139	48	85	85	NUM
admet-376	139	49	-	-	SYM
admet-376	139	50	125	125	NUM
admet-376	139	51	102	102	NUM
admet-376	139	52	figure	figure	NOUN
admet-376	139	53	4	4	NUM
admet-376	139	54	.	.	PUNCT
admet-376	139	55	random	random	ADJ
admet-376	139	56	forest	forest	NOUN
admet-376	139	57	regression	regression	NOUN
admet-376	139	58	of	of	ADP
admet-376	139	59	rdkit	rdkit	ADJ
admet-376	139	60	features	feature	NOUN
admet-376	139	61	on	on	ADP
admet-376	139	62	the	the	DET
admet-376	139	63	rank	rank	NOUN
admet-376	139	64	order	order	NOUN
admet-376	139	65	prediction	prediction	NOUN
admet-376	139	66	of	of	ADP
admet-376	139	67	the	the	DET
admet-376	139	68	tanimoto	tanimoto	PROPN
admet-376	139	69	similarity	similarity	NOUN
admet-376	139	70	of	of	ADP
admet-376	139	71	a	a	DET
admet-376	139	72	given	give	VERB
admet-376	139	73	drug	drug	NOUN
admet-376	139	74	molecule	molecule	NOUN
admet-376	139	75	,	,	PUNCT
admet-376	139	76	using	use	VERB
admet-376	139	77	the	the	DET
admet-376	139	78	rdkit	rdkit	ADJ
admet-376	139	79	fingerprint	fingerprint	NOUN
admet-376	139	80	encoding	encoding	NOUN
admet-376	139	81	(	(	PUNCT
admet-376	139	82	a	a	DET
admet-376	139	83	graph	graph	NOUN
admet-376	139	84	-	-	PUNCT
admet-376	139	85	based	base	VERB
admet-376	139	86	method	method	NOUN
admet-376	139	87	that	that	PRON
admet-376	139	88	should	should	AUX
admet-376	139	89	not	not	PART
admet-376	139	90	of	of	ADP
admet-376	139	91	itself	itself	PRON
admet-376	139	92	be	be	AUX
admet-376	139	93	related	relate	VERB
admet-376	139	94	to	to	ADP
admet-376	139	95	physicochemical	physicochemical	ADJ
admet-376	139	96	descriptors	descriptor	NOUN
admet-376	139	97	)	)	PUNCT
admet-376	139	98	and	and	CCONJ
admet-376	139	99	the	the	DET
admet-376	139	100	tanimoto	tanimoto	NOUN
admet-376	139	101	similarity	similarity	NOUN
admet-376	139	102	.	.	PUNCT
admet-376	140	1	a.	a.	PROPN
admet-376	140	2	predicted	predict	VERB
admet-376	140	3	against	against	ADP
admet-376	140	4	actual	actual	ADJ
admet-376	140	5	.	.	PUNCT
admet-376	141	1	b.	b.	PROPN
admet-376	141	2	ranked	rank	VERB
admet-376	141	3	order	order	NOUN
admet-376	141	4	of	of	ADP
admet-376	141	5	relevant	relevant	ADJ
admet-376	141	6	features	feature	NOUN
admet-376	141	7	.	.	PUNCT
admet-376	142	1	c.	c.	PROPN
admet-376	142	2	stepwise	stepwise	PROPN
admet-376	142	3	improvement	improvement	NOUN
admet-376	142	4	in	in	ADP
admet-376	142	5	regression	regression	NOUN
admet-376	142	6	as	as	SCONJ
admet-376	142	7	features	feature	NOUN
admet-376	142	8	are	be	AUX
admet-376	142	9	added	add	VERB
admet-376	142	10	in	in	ADP
admet-376	142	11	the	the	DET
admet-376	142	12	order	order	NOUN
admet-376	142	13	of	of	ADP
admet-376	142	14	those	those	PRON
admet-376	142	15	seen	see	VERB
admet-376	142	16	in	in	ADP
admet-376	142	17	b.	b.	PROPN
admet-376	142	18	how	how	SCONJ
admet-376	142	19	similar	similar	ADJ
admet-376	142	20	are	be	AUX
admet-376	142	21	drugs	drug	NOUN
admet-376	142	22	to	to	ADP
admet-376	142	23	dietary	dietary	ADJ
admet-376	142	24	and	and	CCONJ
admet-376	142	25	medicinal	medicinal	ADJ
admet-376	142	26	natural	natural	ADJ
admet-376	142	27	products	product	NOUN
admet-376	142	28	from	from	ADP
admet-376	142	29	plants	plant	NOUN
admet-376	142	30	and	and	CCONJ
admet-376	142	31	microbes	microbe	NOUN
admet-376	142	32	?	?	PUNCT
admet-376	143	1	as	as	SCONJ
admet-376	143	2	mentioned	mention	VERB
admet-376	143	3	in	in	ADP
admet-376	143	4	the	the	DET
admet-376	143	5	introduction	introduction	NOUN
admet-376	143	6	,	,	PUNCT
admet-376	143	7	and	and	CCONJ
admet-376	143	8	leaving	leave	VERB
admet-376	143	9	aside	aside	ADV
admet-376	143	10	molecules	molecule	NOUN
admet-376	143	11	that	that	PRON
admet-376	143	12	are	be	AUX
admet-376	143	13	actually	actually	ADV
admet-376	143	14	both	both	CCONJ
admet-376	143	15	drugs	drug	NOUN
admet-376	143	16	and	and	CCONJ
admet-376	143	17	metabolites	metabolite	NOUN
admet-376	143	18	,	,	PUNCT
admet-376	143	19	some	some	DET
admet-376	143	20	drugs	drug	NOUN
admet-376	143	21	are	be	AUX
admet-376	143	22	clearly	clearly	ADV
admet-376	143	23	much	much	ADV
admet-376	143	24	more	more	ADV
admet-376	143	25	similar	similar	ADJ
admet-376	143	26	to	to	ADP
admet-376	143	27	one	one	NUM
admet-376	143	28	or	or	CCONJ
admet-376	143	29	more	more	ADV
admet-376	143	30	endogenous	endogenous	ADJ
admet-376	143	31	metabolites	metabolite	NOUN
admet-376	143	32	than	than	SCONJ
admet-376	143	33	are	be	AUX
admet-376	143	34	others	other	NOUN
admet-376	143	35	,	,	PUNCT
admet-376	143	36	and	and	CCONJ
admet-376	143	37	this	this	PRON
admet-376	143	38	is	be	AUX
admet-376	143	39	true	true	ADJ
admet-376	143	40	for	for	ADP
admet-376	143	41	a	a	DET
admet-376	143	42	variety	variety	NOUN
admet-376	143	43	of	of	ADP
admet-376	143	44	fingerprint	fingerprint	NOUN
admet-376	143	45	encodings	encoding	NOUN
admet-376	143	46	[	[	X
admet-376	143	47	22	22	NUM
admet-376	143	48	]	]	PUNCT
admet-376	143	49	.	.	PUNCT
admet-376	144	1	one	one	NUM
admet-376	144	2	question	question	NOUN
admet-376	144	3	that	that	PRON
admet-376	144	4	we	we	PRON
admet-376	144	5	have	have	AUX
admet-376	144	6	not	not	PART
admet-376	144	7	previously	previously	ADV
admet-376	144	8	asked	ask	VERB
admet-376	144	9	is	be	AUX
admet-376	144	10	about	about	ADP
admet-376	144	11	how	how	SCONJ
admet-376	144	12	much	much	ADV
admet-376	144	13	better	well	ADJ
admet-376	144	14	our	our	PRON
admet-376	144	15	‘	'	PUNCT
admet-376	144	16	similarities	similarity	NOUN
admet-376	144	17	’	'	PUNCT
admet-376	144	18	might	might	AUX
admet-376	144	19	be	be	AUX
admet-376	144	20	if	if	SCONJ
admet-376	144	21	we	we	PRON
admet-376	144	22	also	also	ADV
admet-376	144	23	used	use	VERB
admet-376	144	24	dietary	dietary	ADJ
admet-376	144	25	or	or	CCONJ
admet-376	144	26	bioactive	bioactive	ADJ
admet-376	144	27	molecules	molecule	NOUN
admet-376	144	28	that	that	PRON
admet-376	144	29	are	be	AUX
admet-376	144	30	not	not	PART
admet-376	144	31	in	in	ADP
admet-376	144	32	recon2	recon2	NOUN
admet-376	144	33	.	.	PUNCT
admet-376	145	1	specifically	specifically	ADV
admet-376	145	2	,	,	PUNCT
admet-376	145	3	including	include	VERB
admet-376	145	4	for	for	ADP
admet-376	145	5	evolutionary	evolutionary	ADJ
admet-376	145	6	reasons	reason	NOUN
admet-376	145	7	rehearsed	rehearse	VERB
admet-376	145	8	in	in	ADP
admet-376	145	9	the	the	DET
admet-376	145	10	introduction	introduction	NOUN
admet-376	145	11	,	,	PUNCT
admet-376	145	12	the	the	DET
admet-376	145	13	question	question	NOUN
admet-376	145	14	thus	thus	ADV
admet-376	145	15	arose	arise	VERB
admet-376	145	16	as	as	ADP
admet-376	145	17	to	to	ADP
admet-376	145	18	whether	whether	SCONJ
admet-376	145	19	these	these	DET
admet-376	145	20	similarities	similarity	NOUN
admet-376	145	21	could	could	AUX
admet-376	145	22	be	be	AUX
admet-376	145	23	increased	increase	VERB
admet-376	145	24	,	,	PUNCT
admet-376	145	25	especially	especially	ADV
admet-376	145	26	for	for	ADP
admet-376	145	27	the	the	DET
admet-376	145	28	“	"	PUNCT
admet-376	145	29	less	less	ADV
admet-376	145	30	similar	similar	ADJ
admet-376	145	31	”	"	PUNCT
admet-376	145	32	drugs	drug	NOUN
admet-376	145	33	,	,	PUNCT
admet-376	145	34	when	when	SCONJ
admet-376	145	35	we	we	PRON
admet-376	145	36	began	begin	VERB
admet-376	145	37	to	to	PART
admet-376	145	38	include	include	VERB
admet-376	145	39	bacterial	bacterial	ADJ
admet-376	145	40	,	,	PUNCT
admet-376	145	41	plant	plant	NOUN
admet-376	145	42	,	,	PUNCT
admet-376	145	43	and	and	CCONJ
admet-376	145	44	fungus	fungus	NOUN
admet-376	145	45	-	-	PUNCT
admet-376	145	46	derived	derive	VERB
admet-376	145	47	secondary	secondary	ADJ
admet-376	145	48	metabolites	metabolite	NOUN
admet-376	145	49	.	.	PUNCT
admet-376	146	1	we	we	PRON
admet-376	146	2	recognise	recognise	VERB
admet-376	146	3	that	that	SCONJ
admet-376	146	4	we	we	PRON
admet-376	146	5	must	must	AUX
admet-376	146	6	,	,	PUNCT
admet-376	146	7	so	so	ADV
admet-376	146	8	far	far	ADV
admet-376	146	9	as	as	SCONJ
admet-376	146	10	is	be	AUX
admet-376	146	11	reasonable	reasonable	ADJ
admet-376	146	12	,	,	PUNCT
admet-376	146	13	compare	compare	VERB
admet-376	146	14	like	like	ADP
admet-376	146	15	with	with	ADP
admet-376	146	16	like	like	INTJ
admet-376	146	17	,	,	PUNCT
admet-376	146	18	and	and	CCONJ
admet-376	146	19	certainly	certainly	ADV
admet-376	146	20	it	it	PRON
admet-376	146	21	can	can	AUX
admet-376	146	22	always	always	ADV
admet-376	146	23	be	be	AUX
admet-376	146	24	claimed	claim	VERB
admet-376	146	25	that	that	SCONJ
admet-376	146	26	there	there	PRON
admet-376	146	27	is	be	VERB
admet-376	146	28	a	a	DET
admet-376	146	29	greater	great	ADJ
admet-376	146	30	likelihood	likelihood	NOUN
admet-376	146	31	of	of	ADP
admet-376	146	32	finding	find	VERB
admet-376	146	33	a	a	DET
admet-376	146	34	molecule	molecule	NOUN
admet-376	146	35	with	with	ADP
admet-376	146	36	a	a	DET
admet-376	146	37	greater	great	ADJ
admet-376	146	38	similarity	similarity	NOUN
admet-376	146	39	(	(	PUNCT
admet-376	146	40	in	in	ADP
admet-376	146	41	a	a	DET
admet-376	146	42	given	give	VERB
admet-376	146	43	encoding	encoding	NOUN
admet-376	146	44	)	)	PUNCT
admet-376	146	45	as	as	SCONJ
admet-376	146	46	the	the	DET
admet-376	146	47	size	size	NOUN
admet-376	146	48	of	of	ADP
admet-376	146	49	a	a	DET
admet-376	146	50	database	database	NOUN
admet-376	146	51	is	be	AUX
admet-376	146	52	increased	increase	VERB
admet-376	146	53	per	per	ADP
admet-376	146	54	se	se	X
admet-376	146	55	.	.	PUNCT
admet-376	147	1	the	the	DET
admet-376	147	2	normal	normal	ADJ
admet-376	147	3	way	way	NOUN
admet-376	147	4	of	of	ADP
admet-376	147	5	dealing	deal	VERB
admet-376	147	6	with	with	ADP
admet-376	147	7	this	this	PRON
admet-376	147	8	is	be	AUX
admet-376	147	9	simply	simply	ADV
admet-376	147	10	to	to	PART
admet-376	147	11	quantify	quantify	VERB
admet-376	147	12	the	the	DET
admet-376	147	13	likelihood	likelihood	NOUN
admet-376	147	14	that	that	SCONJ
admet-376	147	15	a	a	DET
admet-376	147	16	given	give	VERB
admet-376	147	17	similarity	similarity	NOUN
admet-376	147	18	could	could	AUX
admet-376	147	19	be	be	AUX
admet-376	147	20	achieved	achieve	VERB
admet-376	147	21	from	from	ADP
admet-376	147	22	a	a	DET
admet-376	147	23	(	(	PUNCT
admet-376	147	24	more	more	ADJ
admet-376	147	25	or	or	CCONJ
admet-376	147	26	less	less	ADV
admet-376	147	27	random	random	ADJ
admet-376	147	28	)	)	PUNCT
admet-376	147	29	distribution	distribution	NOUN
admet-376	147	30	of	of	ADP
admet-376	147	31	chemicals	chemical	NOUN
admet-376	147	32	taken	take	VERB
admet-376	147	33	from	from	ADP
admet-376	147	34	that	that	DET
admet-376	147	35	database	database	NOUN
admet-376	147	36	[	[	X
admet-376	147	37	34	34	NUM
admet-376	147	38	,	,	PUNCT
admet-376	147	39	110	110	NUM
admet-376	147	40	-	-	SYM
admet-376	147	41	114	114	NUM
admet-376	147	42	]	]	PUNCT
admet-376	147	43	.	.	PUNCT
admet-376	148	1	this	this	PRON
admet-376	148	2	is	be	AUX
admet-376	148	3	not	not	PART
admet-376	148	4	entirely	entirely	ADV
admet-376	148	5	logical	logical	ADJ
admet-376	148	6	from	from	ADP
admet-376	148	7	a	a	DET
admet-376	148	8	biological	biological	ADJ
admet-376	148	9	point	point	NOUN
admet-376	148	10	of	of	ADP
admet-376	148	11	view	view	NOUN
admet-376	148	12	,	,	PUNCT
admet-376	148	13	however	however	ADV
admet-376	148	14	,	,	PUNCT
admet-376	148	15	since	since	SCONJ
admet-376	148	16	such	such	ADJ
admet-376	148	17	samples	sample	NOUN
admet-376	148	18	are	be	AUX
admet-376	148	19	not	not	PART
admet-376	148	20	(	(	PUNCT
admet-376	148	21	from	from	ADP
admet-376	148	22	)	)	PUNCT
admet-376	148	23	a	a	DET
admet-376	148	24	random	random	ADJ
admet-376	148	25	distribution	distribution	NOUN
admet-376	148	26	but	but	CCONJ
admet-376	148	27	are	be	AUX
admet-376	148	28	the	the	DET
admet-376	148	29	products	product	NOUN
admet-376	148	30	of	of	ADP
admet-376	148	31	evolutionary	evolutionary	ADJ
admet-376	148	32	selection	selection	NOUN
admet-376	148	33	.	.	PUNCT
admet-376	149	1	thus	thus	ADV
admet-376	149	2	we	we	PRON
admet-376	149	3	prefer	prefer	VERB
admet-376	149	4	other	other	ADJ
admet-376	149	5	arguments	argument	NOUN
admet-376	149	6	,	,	PUNCT
admet-376	149	7	based	base	VERB
admet-376	149	8	on	on	ADP
admet-376	149	9	comparing	compare	VERB
admet-376	149	10	biologically	biologically	ADV
admet-376	149	11	relevant	relevant	ADJ
admet-376	149	12	databases	database	NOUN
admet-376	149	13	.	.	PUNCT
admet-376	150	1	we	we	PRON
admet-376	150	2	do	do	VERB
admet-376	150	3	,	,	PUNCT
admet-376	150	4	however	however	ADV
admet-376	150	5	,	,	PUNCT
admet-376	150	6	also	also	ADV
admet-376	150	7	recognise	recognise	VERB
admet-376	150	8	that	that	SCONJ
admet-376	150	9	the	the	DET
admet-376	150	10	gross	gross	ADJ
admet-376	150	11	distribution	distribution	NOUN
admet-376	150	12	of	of	ADP
admet-376	150	13	properties	property	NOUN
admet-376	150	14	such	such	ADJ
admet-376	150	15	as	as	ADP
admet-376	150	16	mw	mw	PROPN
admet-376	150	17	,	,	PUNCT
admet-376	150	18	log	log	VERB
admet-376	150	19	p	p	NOUN
admet-376	150	20	,	,	PUNCT
admet-376	150	21	total	total	ADJ
admet-376	150	22	polar	polar	ADJ
admet-376	150	23	surface	surface	NOUN
admet-376	150	24	area	area	NOUN
admet-376	150	25	(	(	PUNCT
admet-376	150	26	tpsa	tpsa	NOUN
admet-376	150	27	)	)	PUNCT
admet-376	150	28	and	and	CCONJ
admet-376	150	29	so	so	ADV
admet-376	150	30	on	on	ADP
admet-376	150	31	differs	differ	NOUN
admet-376	150	32	between	between	ADP
admet-376	150	33	the	the	DET
admet-376	150	34	different	different	ADJ
admet-376	150	35	databases	database	NOUN
admet-376	150	36	,	,	PUNCT
admet-376	150	37	and	and	CCONJ
admet-376	150	38	we	we	PRON
admet-376	150	39	will	will	AUX
admet-376	150	40	need	need	VERB
admet-376	150	41	to	to	PART
admet-376	150	42	ensure	ensure	VERB
admet-376	150	43	that	that	SCONJ
admet-376	150	44	this	this	PRON
admet-376	150	45	is	be	AUX
admet-376	150	46	not	not	PART
admet-376	150	47	a	a	DET
admet-376	150	48	trivial	trivial	ADJ
admet-376	150	49	cause	cause	NOUN
admet-376	150	50	of	of	ADP
admet-376	150	51	any	any	DET
admet-376	150	52	differences	difference	NOUN
admet-376	150	53	observed	observe	VERB
admet-376	150	54	.	.	PUNCT
admet-376	151	1	thus	thus	ADV
admet-376	151	2	in	in	ADP
admet-376	151	3	some	some	DET
admet-376	151	4	cases	case	NOUN
admet-376	151	5	we	we	PRON
admet-376	151	6	used	use	VERB
admet-376	151	7	the	the	DET
admet-376	151	8	matchit	matchit	ADJ
admet-376	151	9	algorithm	algorithm	NOUN
admet-376	151	10	[	[	X
admet-376	151	11	134	134	NUM
admet-376	151	12	,	,	PUNCT
admet-376	151	13	135	135	NUM
admet-376	151	14	]	]	PUNCT
admet-376	151	15	(	(	PUNCT
admet-376	151	16	and	and	CCONJ
admet-376	151	17	its	its	PRON
admet-376	151	18	attendant	attendant	NOUN
admet-376	151	19	r	r	PROPN
admet-376	151	20	code	code	NOUN
admet-376	151	21	)	)	PUNCT
admet-376	151	22	to	to	PART
admet-376	151	23	select	select	VERB
admet-376	151	24	subsets	subset	NOUN
admet-376	151	25	from	from	ADP
admet-376	151	26	the	the	DET
admet-376	151	27	various	various	ADJ
admet-376	151	28	databases	database	NOUN
admet-376	151	29	with	with	ADP
admet-376	151	30	the	the	DET
admet-376	151	31	same	same	ADJ
admet-376	151	32	distributions	distribution	NOUN
admet-376	151	33	of	of	ADP
admet-376	151	34	properties	property	NOUN
admet-376	151	35	as	as	ADP
admet-376	151	36	admet	admet	PROPN
admet-376	151	37	&	&	CCONJ
admet-376	151	38	dmpk	dmpk	PROPN
admet-376	151	39	5(2	5(2	NUM
admet-376	151	40	)	)	PUNCT
admet-376	151	41	(	(	PUNCT
admet-376	151	42	2017	2017	NUM
admet-376	151	43	)	)	PUNCT
admet-376	151	44	85	85	NUM
admet-376	151	45	-	-	SYM
admet-376	151	46	125	125	NUM
admet-376	151	47	exogenous	exogenous	ADJ
admet-376	151	48	natural	natural	ADJ
admet-376	151	49	products	product	NOUN
admet-376	151	50	as	as	ADP
admet-376	151	51	‘	'	PUNCT
admet-376	151	52	natural	natural	ADJ
admet-376	151	53	’	'	PUNCT
admet-376	151	54	drug	drug	NOUN
admet-376	151	55	transporter	transporter	NOUN
admet-376	151	56	substrates	substrate	VERB
admet-376	151	57	doi	doi	NOUN
admet-376	151	58	:	:	PUNCT
admet-376	151	59	10.5599	10.5599	NUM
admet-376	151	60	/	/	SYM
admet-376	151	61	admet.5.2.376	admet.5.2.376	PROPN
admet-376	151	62	103	103	NUM
admet-376	151	63	those	those	PRON
admet-376	151	64	of	of	ADP
admet-376	151	65	endogenites	endogenite	NOUN
admet-376	151	66	.	.	PUNCT
admet-376	152	1	the	the	DET
admet-376	152	2	“	"	PUNCT
admet-376	152	3	universal	universal	ADJ
admet-376	152	4	natural	natural	ADJ
admet-376	152	5	products	product	NOUN
admet-376	152	6	database	database	NOUN
admet-376	152	7	”	"	PUNCT
admet-376	152	8	(	(	PUNCT
admet-376	152	9	unpd	unpd	PROPN
admet-376	152	10	)	)	PUNCT
admet-376	152	11	(	(	PUNCT
admet-376	152	12	http://pkuxxj.pku.edu.cn/unpd	http://pkuxxj.pku.edu.cn/unpd	NOUN
admet-376	152	13	)	)	PUNCT
admet-376	152	14	is	be	AUX
admet-376	152	15	said	say	VERB
admet-376	152	16	[	[	X
admet-376	152	17	123	123	NUM
admet-376	152	18	]	]	PUNCT
admet-376	152	19	to	to	PART
admet-376	152	20	be	be	AUX
admet-376	152	21	the	the	DET
admet-376	152	22	largest	large	ADJ
admet-376	152	23	noncommercial	noncommercial	ADJ
admet-376	152	24	and	and	CCONJ
admet-376	152	25	freely	freely	ADV
admet-376	152	26	available	available	ADJ
admet-376	152	27	database	database	NOUN
admet-376	152	28	for	for	ADP
admet-376	152	29	natural	natural	ADJ
admet-376	152	30	products	product	NOUN
admet-376	152	31	.	.	PUNCT
admet-376	153	1	at	at	ADP
admet-376	153	2	the	the	DET
admet-376	153	3	time	time	NOUN
admet-376	153	4	of	of	ADP
admet-376	153	5	its	its	PRON
admet-376	153	6	original	original	ADJ
admet-376	153	7	publication	publication	NOUN
admet-376	153	8	[	[	X
admet-376	153	9	123	123	NUM
admet-376	153	10	]	]	X
admet-376	153	11	unpd	unpd	NOUN
admet-376	153	12	comprised	comprise	VERB
admet-376	153	13	197,201	197,201	NUM
admet-376	153	14	natural	natural	ADJ
admet-376	153	15	products	product	NOUN
admet-376	153	16	from	from	ADP
admet-376	153	17	plants	plant	NOUN
admet-376	153	18	,	,	PUNCT
admet-376	153	19	animals	animal	NOUN
admet-376	153	20	and	and	CCONJ
admet-376	153	21	microorganisms	microorganism	NOUN
admet-376	153	22	.	.	PUNCT
admet-376	154	1	our	our	PRON
admet-376	154	2	first	first	ADJ
admet-376	154	3	task	task	NOUN
admet-376	154	4	here	here	ADV
admet-376	154	5	involved	involve	VERB
admet-376	154	6	regularising	regularise	VERB
admet-376	154	7	or	or	CCONJ
admet-376	154	8	‘	'	PUNCT
admet-376	154	9	cleaning	cleaning	NOUN
admet-376	154	10	’	'	PUNCT
admet-376	154	11	the	the	DET
admet-376	154	12	unpd	unpd	NOUN
admet-376	154	13	for	for	ADP
admet-376	154	14	our	our	PRON
admet-376	154	15	purposes	purpose	NOUN
admet-376	154	16	.	.	PUNCT
admet-376	155	1	cleaning	cleaning	NOUN
admet-376	155	2	was	be	AUX
admet-376	155	3	perfomed	perfome	VERB
admet-376	155	4	using	use	VERB
admet-376	155	5	a	a	DET
admet-376	155	6	knime	knime	ADJ
admet-376	155	7	workflow	workflow	NOUN
admet-376	155	8	and	and	CCONJ
admet-376	155	9	lowered	lower	VERB
admet-376	155	10	the	the	DET
admet-376	155	11	number	number	NOUN
admet-376	155	12	of	of	ADP
admet-376	155	13	molecules	molecule	NOUN
admet-376	155	14	included	include	VERB
admet-376	155	15	from	from	ADP
admet-376	155	16	the	the	DET
admet-376	155	17	ca	ca	NOUN
admet-376	155	18	229,000	229,000	NUM
admet-376	155	19	initially	initially	ADV
admet-376	155	20	logged	log	VERB
admet-376	155	21	when	when	SCONJ
admet-376	155	22	we	we	PRON
admet-376	155	23	downloaded	download	VERB
admet-376	155	24	it	it	PRON
admet-376	155	25	in	in	ADP
admet-376	155	26	december	december	PROPN
admet-376	155	27	2016	2016	NUM
admet-376	155	28	to	to	ADP
admet-376	155	29	155,048	155,048	NUM
admet-376	155	30	.	.	PUNCT
admet-376	156	1	the	the	DET
admet-376	156	2	main	main	ADJ
admet-376	156	3	‘	'	PUNCT
admet-376	156	4	loss	loss	NOUN
admet-376	156	5	’	'	PUNCT
admet-376	156	6	was	be	AUX
admet-376	156	7	due	due	ADJ
admet-376	156	8	to	to	ADP
admet-376	156	9	the	the	DET
admet-376	156	10	loss	loss	NOUN
admet-376	156	11	of	of	ADP
admet-376	156	12	(	(	PUNCT
admet-376	156	13	what	what	PRON
admet-376	156	14	we	we	PRON
admet-376	156	15	could	could	AUX
admet-376	156	16	not	not	PART
admet-376	156	17	deconvolve	deconvolve	VERB
admet-376	156	18	as	as	ADP
admet-376	156	19	)	)	PUNCT
admet-376	156	20	duplicates	duplicate	NOUN
admet-376	156	21	.	.	PUNCT
admet-376	157	1	some	some	PRON
admet-376	157	2	of	of	ADP
admet-376	157	3	these	these	PRON
admet-376	157	4	may	may	AUX
admet-376	157	5	have	have	AUX
admet-376	157	6	been	be	AUX
admet-376	157	7	stereoisomers	stereoisomer	NOUN
admet-376	157	8	,	,	PUNCT
admet-376	157	9	but	but	CCONJ
admet-376	157	10	the	the	DET
admet-376	157	11	2d	2d	PROPN
admet-376	157	12	connection	connection	NOUN
admet-376	157	13	table	table	NOUN
admet-376	157	14	provided	provide	VERB
admet-376	157	15	contained	contain	VERB
admet-376	157	16	no	no	DET
admet-376	157	17	stereochemistry	stereochemistry	NOUN
admet-376	157	18	.	.	PUNCT
admet-376	158	1	figure	figure	NOUN
admet-376	158	2	5	5	NUM
admet-376	158	3	shows	show	VERB
admet-376	158	4	the	the	DET
admet-376	158	5	distributions	distribution	NOUN
admet-376	158	6	of	of	ADP
admet-376	158	7	four	four	NUM
admet-376	158	8	properties	property	NOUN
admet-376	158	9	between	between	ADP
admet-376	158	10	the	the	DET
admet-376	158	11	endogenous	endogenous	ADJ
admet-376	158	12	metabolites	metabolite	NOUN
admet-376	158	13	of	of	ADP
admet-376	158	14	recon2	recon2	NOUN
admet-376	158	15	and	and	CCONJ
admet-376	158	16	the	the	DET
admet-376	158	17	contents	content	NOUN
admet-376	158	18	[	[	X
admet-376	158	19	123	123	NUM
admet-376	158	20	]	]	PUNCT
admet-376	158	21	of	of	ADP
admet-376	158	22	the	the	DET
admet-376	158	23	‘	'	PUNCT
admet-376	158	24	cleaned	clean	VERB
admet-376	158	25	’	'	PUNCT
admet-376	158	26	unpd	unpd	PROPN
admet-376	158	27	natural	natural	ADJ
admet-376	158	28	products	product	NOUN
admet-376	158	29	database	database	NOUN
admet-376	158	30	.	.	PUNCT
admet-376	159	1	although	although	SCONJ
admet-376	159	2	there	there	PRON
admet-376	159	3	are	be	VERB
admet-376	159	4	clear	clear	ADJ
admet-376	159	5	differences	difference	NOUN
admet-376	159	6	,	,	PUNCT
admet-376	159	7	they	they	PRON
admet-376	159	8	are	be	AUX
admet-376	159	9	in	in	ADP
admet-376	159	10	fact	fact	NOUN
admet-376	159	11	surprisingly	surprisingly	ADV
admet-376	159	12	similar	similar	ADJ
admet-376	159	13	(	(	PUNCT
admet-376	159	14	see	see	VERB
admet-376	159	15	also	also	ADV
admet-376	159	16	[	[	X
admet-376	159	17	22	22	NUM
admet-376	159	18	,	,	PUNCT
admet-376	159	19	123	123	NUM
admet-376	159	20	]	]	PUNCT
admet-376	159	21	)	)	PUNCT
admet-376	159	22	,	,	PUNCT
admet-376	159	23	and	and	CCONJ
admet-376	159	24	as	as	SCONJ
admet-376	159	25	noted	note	VERB
admet-376	159	26	above	above	ADV
admet-376	159	27	,	,	PUNCT
admet-376	159	28	individual	individual	ADJ
admet-376	159	29	descriptors	descriptor	NOUN
admet-376	159	30	had	have	VERB
admet-376	159	31	only	only	ADV
admet-376	159	32	a	a	DET
admet-376	159	33	minor	minor	ADJ
admet-376	159	34	influence	influence	NOUN
admet-376	159	35	on	on	ADP
admet-376	159	36	the	the	DET
admet-376	159	37	random	random	ADJ
admet-376	159	38	forest	forest	NOUN
admet-376	159	39	model	model	NOUN
admet-376	159	40	.	.	PUNCT
admet-376	160	1	we	we	PRON
admet-376	160	2	next	next	ADV
admet-376	160	3	(	(	PUNCT
admet-376	160	4	figure	figure	VERB
admet-376	160	5	6a	6a	NOUN
admet-376	160	6	)	)	PUNCT
admet-376	160	7	compared	compare	VERB
admet-376	160	8	the	the	DET
admet-376	160	9	ordered	order	VERB
admet-376	160	10	results	result	NOUN
admet-376	160	11	of	of	ADP
admet-376	160	12	the	the	DET
admet-376	160	13	tanimoto	tanimoto	NOUN
admet-376	160	14	similarity	similarity	NOUN
admet-376	160	15	of	of	ADP
admet-376	160	16	the	the	DET
admet-376	160	17	various	various	ADJ
admet-376	160	18	marketed	market	VERB
admet-376	160	19	drugs	drug	NOUN
admet-376	160	20	to	to	ADP
admet-376	160	21	those	those	PRON
admet-376	160	22	of	of	ADP
admet-376	160	23	the	the	DET
admet-376	160	24	nearest	near	ADJ
admet-376	160	25	representative	representative	NOUN
admet-376	160	26	in	in	ADP
admet-376	160	27	our	our	PRON
admet-376	160	28	‘	'	PUNCT
admet-376	160	29	cleaned	clean	VERB
admet-376	160	30	’	'	PUNCT
admet-376	160	31	version	version	NOUN
admet-376	160	32	of	of	ADP
admet-376	160	33	unpd	unpd	NOUN
admet-376	160	34	.	.	PUNCT
admet-376	161	1	the	the	DET
admet-376	161	2	results	result	NOUN
admet-376	161	3	are	be	AUX
admet-376	161	4	absolutely	absolutely	ADV
admet-376	161	5	striking	striking	ADJ
admet-376	161	6	;	;	PUNCT
admet-376	161	7	while	while	SCONJ
admet-376	161	8	90	90	NUM
admet-376	161	9	%	%	NOUN
admet-376	161	10	of	of	ADP
admet-376	161	11	marketed	market	VERB
admet-376	161	12	drugs	drug	NOUN
admet-376	161	13	had	have	VERB
admet-376	161	14	an	an	DET
admet-376	161	15	endogenite	endogenite	NOUN
admet-376	161	16	with	with	ADP
admet-376	161	17	a	a	DET
admet-376	161	18	ts	ts	X
admet-376	161	19	>	>	X
admet-376	161	20	0.5	0.5	NUM
admet-376	161	21	,	,	PUNCT
admet-376	161	22	the	the	DET
admet-376	161	23	corresponding	corresponding	ADJ
admet-376	161	24	value	value	NOUN
admet-376	161	25	for	for	ADP
admet-376	161	26	unpd	unpd	NOUN
admet-376	161	27	of	of	ADP
admet-376	161	28	90	90	NUM
admet-376	161	29	%	%	NOUN
admet-376	161	30	was	be	AUX
admet-376	161	31	a	a	DET
admet-376	161	32	ts	ts	NOUN
admet-376	161	33	of	of	ADP
admet-376	161	34	0.7	0.7	NUM
admet-376	161	35	.	.	PUNCT
admet-376	161	36	table	table	NOUN
admet-376	161	37	1	1	NUM
admet-376	161	38	shows	show	VERB
admet-376	161	39	the	the	DET
admet-376	161	40	%	%	NOUN
admet-376	161	41	age	age	NOUN
admet-376	161	42	of	of	ADP
admet-376	161	43	drugs	drug	NOUN
admet-376	161	44	with	with	ADP
admet-376	161	45	a	a	DET
admet-376	161	46	closest	close	ADJ
admet-376	161	47	molecule	molecule	NOUN
admet-376	161	48	with	with	ADP
admet-376	161	49	a	a	DET
admet-376	161	50	ts	ts	ADP
admet-376	161	51	exceeding	exceed	VERB
admet-376	161	52	various	various	ADJ
admet-376	161	53	values	value	NOUN
admet-376	161	54	(	(	PUNCT
admet-376	161	55	maccs	maccs	PROPN
admet-376	161	56	encoding	encoding	NOUN
admet-376	161	57	)	)	PUNCT
admet-376	161	58	for	for	ADP
admet-376	161	59	endogenites	endogenite	NOUN
admet-376	161	60	and	and	CCONJ
admet-376	161	61	unpd	unpd	NOUN
admet-376	161	62	library	library	NOUN
admet-376	161	63	members	member	NOUN
admet-376	161	64	.	.	PUNCT
admet-376	162	1	fairly	fairly	ADV
admet-376	162	2	obviously	obviously	ADV
admet-376	162	3	,	,	PUNCT
admet-376	162	4	the	the	DET
admet-376	162	5	chance	chance	NOUN
admet-376	162	6	of	of	ADP
admet-376	162	7	finding	find	VERB
admet-376	162	8	a	a	DET
admet-376	162	9	close	close	ADJ
admet-376	162	10	homologue	homologue	NOUN
admet-376	162	11	is	be	AUX
admet-376	162	12	massively	massively	ADV
admet-376	162	13	greater	great	ADJ
admet-376	162	14	(	(	PUNCT
admet-376	162	15	often	often	ADV
admet-376	162	16	four	four	NUM
admet-376	162	17	-	-	ADJ
admet-376	162	18	fold	fold	ADJ
admet-376	162	19	or	or	CCONJ
admet-376	162	20	more	more	ADJ
admet-376	162	21	)	)	PUNCT
admet-376	162	22	for	for	ADP
admet-376	162	23	the	the	DET
admet-376	162	24	latter	latter	ADJ
admet-376	162	25	,	,	PUNCT
admet-376	162	26	especially	especially	ADV
admet-376	162	27	for	for	ADP
admet-376	162	28	ts	ts	ADP
admet-376	162	29	values	value	NOUN
admet-376	162	30	greater	great	ADJ
admet-376	162	31	than	than	ADP
admet-376	162	32	about	about	ADP
admet-376	162	33	0.7	0.7	NUM
admet-376	162	34	.	.	PUNCT
admet-376	163	1	figure	figure	NOUN
admet-376	163	2	5	5	NUM
admet-376	163	3	.	.	PUNCT
admet-376	164	1	distribution	distribution	NOUN
admet-376	164	2	of	of	ADP
admet-376	164	3	four	four	NUM
admet-376	164	4	properties	property	NOUN
admet-376	164	5	between	between	ADP
admet-376	164	6	the	the	DET
admet-376	164	7	endogenous	endogenous	ADJ
admet-376	164	8	metabolites	metabolite	NOUN
admet-376	164	9	of	of	ADP
admet-376	164	10	recon	recon	NOUN
admet-376	164	11	2	2	NUM
admet-376	165	1	[	[	X
admet-376	165	2	136	136	NUM
admet-376	165	3	]	]	PUNCT
admet-376	165	4	and	and	CCONJ
admet-376	165	5	the	the	DET
admet-376	165	6	cleaned	clean	VERB
admet-376	165	7	version	version	NOUN
admet-376	165	8	of	of	ADP
admet-376	165	9	unpd	unpd	NOUN
admet-376	165	10	[	[	X
admet-376	165	11	123	123	NUM
admet-376	165	12	]	]	PUNCT
admet-376	165	13	.	.	PUNCT
admet-376	166	1	the	the	DET
admet-376	166	2	original	original	ADJ
admet-376	166	3	unpd	unpd	NOUN
admet-376	166	4	file	file	NOUN
admet-376	166	5	as	as	SCONJ
admet-376	166	6	downloaded	download	VERB
admet-376	166	7	contained	contain	VERB
admet-376	166	8	229,358	229,358	NUM
admet-376	166	9	molecules	molecule	NOUN
admet-376	166	10	.	.	PUNCT
admet-376	167	1	‘	'	PUNCT
admet-376	167	2	cleaning	clean	VERB
admet-376	167	3	’	'	PUNCT
admet-376	167	4	removed	remove	VERB
admet-376	167	5	duplicates	duplicate	NOUN
admet-376	167	6	as	as	ADV
admet-376	167	7	well	well	ADV
admet-376	167	8	as	as	ADP
admet-376	167	9	molecules	molecule	NOUN
admet-376	167	10	that	that	PRON
admet-376	167	11	were	be	AUX
admet-376	167	12	in	in	ADP
admet-376	167	13	either	either	DET
admet-376	167	14	recon2	recon2	NOUN
admet-376	167	15	or	or	CCONJ
admet-376	167	16	in	in	ADP
admet-376	167	17	the	the	DET
admet-376	167	18	list	list	NOUN
admet-376	167	19	of	of	ADP
admet-376	167	20	marketed	market	VERB
admet-376	167	21	drugs	drug	NOUN
admet-376	167	22	,	,	PUNCT
admet-376	167	23	both	both	PRON
admet-376	167	24	of	of	ADP
admet-376	167	25	which	which	PRON
admet-376	167	26	were	be	AUX
admet-376	167	27	precisely	precisely	ADV
admet-376	167	28	as	as	ADV
admet-376	167	29	described	describe	VERB
admet-376	167	30	and	and	CCONJ
admet-376	167	31	used	use	VERB
admet-376	167	32	previously	previously	ADV
admet-376	167	33	[	[	X
admet-376	167	34	22	22	NUM
admet-376	167	35	-	-	SYM
admet-376	167	36	24	24	NUM
admet-376	167	37	]	]	PUNCT
admet-376	167	38	.	.	PUNCT
admet-376	168	1	the	the	DET
admet-376	168	2	resulting	result	VERB
admet-376	168	3	spreadsheet	spreadsheet	NOUN
admet-376	168	4	retained	retain	VERB
admet-376	168	5	resulted	result	VERB
admet-376	168	6	in	in	ADP
admet-376	168	7	a	a	DET
admet-376	168	8	total	total	NOUN
admet-376	168	9	of	of	ADP
admet-376	168	10	155,048	155,048	NUM
admet-376	168	11	molecules	molecule	NOUN
admet-376	168	12	.	.	PUNCT
admet-376	169	1	the	the	DET
admet-376	169	2	smoothed	smoothed	ADJ
admet-376	169	3	version	version	NOUN
admet-376	169	4	is	be	AUX
admet-376	169	5	the	the	DET
admet-376	169	6	probability	probability	NOUN
admet-376	169	7	density	density	NOUN
admet-376	169	8	as	as	SCONJ
admet-376	169	9	derived	derive	VERB
admet-376	169	10	from	from	ADP
admet-376	169	11	the	the	DET
admet-376	169	12	r	r	NOUN
admet-376	169	13	-	-	PUNCT
admet-376	169	14	encoded	encode	VERB
admet-376	169	15	kernel	kernel	PROPN
admet-376	169	16	density	density	NOUN
admet-376	169	17	estimator	estimator	NOUN
admet-376	169	18	at	at	ADP
admet-376	169	19	https://www.rdocumentation.org/packages/stats/versions/3.3.2/topics/density	https://www.rdocumentation.org/packages/stats/versions/3.3.2/topics/density	PROPN
admet-376	169	20	.	.	PUNCT
admet-376	170	1	http://pkuxxj.pku.edu.cn/unpd	http://pkuxxj.pku.edu.cn/unpd	PROPN
admet-376	170	2	https://www.rdocumentation.org/packages/stats/versions/3.3.2/topics/density	https://www.rdocumentation.org/packages/stats/versions/3.3.2/topics/density	PROPN
admet-376	170	3	o'hagan	o'hagan	PROPN
admet-376	170	4	&	&	CCONJ
admet-376	170	5	kell	kell	PROPN
admet-376	170	6	admet	admet	PROPN
admet-376	170	7	&	&	CCONJ
admet-376	170	8	dmpk	dmpk	PROPN
admet-376	170	9	5(2	5(2	NUM
admet-376	170	10	)	)	PUNCT
admet-376	170	11	(	(	PUNCT
admet-376	170	12	2017	2017	NUM
admet-376	170	13	)	)	PUNCT
admet-376	170	14	85	85	NUM
admet-376	170	15	-	-	SYM
admet-376	170	16	125	125	NUM
admet-376	170	17	104	104	NUM
admet-376	170	18	figure	figure	NOUN
admet-376	170	19	6	6	NUM
admet-376	170	20	.	.	PUNCT
admet-376	170	21	relationship	relationship	NOUN
admet-376	170	22	between	between	ADP
admet-376	170	23	the	the	DET
admet-376	170	24	normalised	normalise	VERB
admet-376	170	25	rank	rank	NOUN
admet-376	170	26	order	order	NOUN
admet-376	170	27	of	of	ADP
admet-376	170	28	the	the	DET
admet-376	170	29	nearest	near	ADJ
admet-376	170	30	database	database	NOUN
admet-376	170	31	molecule	molecule	NOUN
admet-376	170	32	to	to	ADP
admet-376	170	33	marketed	market	VERB
admet-376	170	34	drugs	drug	NOUN
admet-376	170	35	for	for	ADP
admet-376	170	36	(	(	PUNCT
admet-376	170	37	red	red	PROPN
admet-376	170	38	)	)	PUNCT
admet-376	170	39	the	the	DET
admet-376	170	40	cleaned	clean	VERB
admet-376	170	41	version	version	NOUN
admet-376	170	42	of	of	ADP
admet-376	170	43	unpd	unpd	NOUN
admet-376	170	44	[	[	X
admet-376	170	45	123	123	NUM
admet-376	170	46	]	]	PUNCT
admet-376	170	47	and	and	CCONJ
admet-376	170	48	(	(	PUNCT
admet-376	170	49	blue	blue	ADJ
admet-376	170	50	)	)	PUNCT
admet-376	170	51	recon2	recon2	NOUN
admet-376	170	52	.	.	PUNCT
admet-376	171	1	‘	'	PUNCT
admet-376	171	2	cleaning	clean	VERB
admet-376	171	3	’	'	PUNCT
admet-376	171	4	removed	remove	VERB
admet-376	171	5	duplicates	duplicate	NOUN
admet-376	171	6	as	as	ADV
admet-376	171	7	well	well	ADV
admet-376	171	8	as	as	ADP
admet-376	171	9	molecules	molecule	NOUN
admet-376	171	10	that	that	PRON
admet-376	171	11	were	be	AUX
admet-376	171	12	in	in	ADP
admet-376	171	13	either	either	DET
admet-376	171	14	recon2	recon2	NOUN
admet-376	171	15	or	or	CCONJ
admet-376	171	16	in	in	ADP
admet-376	171	17	the	the	DET
admet-376	171	18	list	list	NOUN
admet-376	171	19	of	of	ADP
admet-376	171	20	marketed	market	VERB
admet-376	171	21	drugs	drug	NOUN
admet-376	171	22	,	,	PUNCT
admet-376	171	23	both	both	PRON
admet-376	171	24	of	of	ADP
admet-376	171	25	which	which	PRON
admet-376	171	26	were	be	AUX
admet-376	171	27	precisely	precisely	ADV
admet-376	171	28	as	as	ADV
admet-376	171	29	described	describe	VERB
admet-376	171	30	and	and	CCONJ
admet-376	171	31	used	use	VERB
admet-376	171	32	previously	previously	ADV
admet-376	171	33	[	[	X
admet-376	171	34	22	22	NUM
admet-376	171	35	-	-	SYM
admet-376	171	36	24	24	NUM
admet-376	171	37	]	]	PUNCT
admet-376	171	38	.	.	PUNCT
admet-376	172	1	a.	a.	PROPN
admet-376	172	2	full	full	ADJ
admet-376	172	3	,	,	PUNCT
admet-376	172	4	cleaned	clean	VERB
admet-376	172	5	version	version	NOUN
admet-376	172	6	of	of	ADP
admet-376	172	7	unpd	unpd	NOUN
admet-376	172	8	.	.	PUNCT
admet-376	173	1	b.	b.	PROPN
admet-376	173	2	a	a	DET
admet-376	173	3	sampled	sample	VERB
admet-376	173	4	version	version	NOUN
admet-376	173	5	of	of	ADP
admet-376	173	6	unpd	unpd	NOUN
admet-376	173	7	using	use	VERB
admet-376	173	8	the	the	DET
admet-376	173	9	same	same	ADJ
admet-376	173	10	number	number	NOUN
admet-376	173	11	of	of	ADP
admet-376	173	12	molecules	molecule	NOUN
admet-376	173	13	as	as	ADP
admet-376	173	14	those	those	PRON
admet-376	173	15	in	in	ADP
admet-376	173	16	recon2	recon2	NOUN
admet-376	173	17	sampled	sample	VERB
admet-376	173	18	as	as	ADP
admet-376	173	19	per	per	ADP
admet-376	173	20	the	the	DET
admet-376	173	21	distributions	distribution	NOUN
admet-376	173	22	in	in	ADP
admet-376	173	23	figure	figure	NOUN
admet-376	173	24	5	5	NUM
admet-376	173	25	.	.	PUNCT
admet-376	173	26	table	table	NOUN
admet-376	173	27	1	1	NUM
admet-376	173	28	.	.	X
admet-376	174	1	tabulation	tabulation	NOUN
admet-376	174	2	of	of	ADP
admet-376	174	3	data	datum	NOUN
admet-376	174	4	from	from	ADP
admet-376	174	5	figure	figure	NOUN
admet-376	174	6	6a	6a	NOUN
admet-376	174	7	.	.	PUNCT
admet-376	175	1	ts	ts	X
admet-376	175	2	>	>	X
admet-376	175	3	at	at	ADP
admet-376	175	4	least	least	ADJ
admet-376	175	5	drugs	drug	NOUN
admet-376	175	6	/	/	SYM
admet-376	175	7	endogenites	endogenite	NOUN
admet-376	175	8	(	(	PUNCT
admet-376	175	9	%	%	NOUN
admet-376	175	10	drugs	drug	NOUN
admet-376	175	11	)	)	PUNCT
admet-376	175	12	drugs	drug	NOUN
admet-376	175	13	/	/	SYM
admet-376	175	14	unpd	unpd	NOUN
admet-376	175	15	(	(	PUNCT
admet-376	175	16	%	%	NOUN
admet-376	175	17	drugs	drug	NOUN
admet-376	175	18	)	)	PUNCT
admet-376	175	19	0.5	0.5	NUM
admet-376	175	20	1185	1185	NUM
admet-376	175	21	(	(	PUNCT
admet-376	175	22	85.8	85.8	NUM
admet-376	175	23	%	%	NOUN
admet-376	175	24	)	)	PUNCT
admet-376	175	25	1375	1375	NUM
admet-376	175	26	(	(	PUNCT
admet-376	175	27	99.6	99.6	NUM
admet-376	175	28	%	%	NOUN
admet-376	175	29	)	)	PUNCT
admet-376	175	30	0.55	0.55	NUM
admet-376	175	31	941	941	NUM
admet-376	175	32	(	(	PUNCT
admet-376	175	33	68.1	68.1	NUM
admet-376	175	34	%	%	NOUN
admet-376	175	35	)	)	PUNCT
admet-376	175	36	1368	1368	NUM
admet-376	175	37	(	(	PUNCT
admet-376	175	38	99.1	99.1	NUM
admet-376	175	39	%	%	NOUN
admet-376	175	40	)	)	PUNCT
admet-376	175	41	0.6	0.6	NUM
admet-376	175	42	708	708	NUM
admet-376	175	43	(	(	PUNCT
admet-376	175	44	51.3	51.3	NUM
admet-376	175	45	%	%	NOUN
admet-376	175	46	)	)	PUNCT
admet-376	175	47	1339	1339	NUM
admet-376	175	48	(	(	PUNCT
admet-376	175	49	97.0	97.0	NUM
admet-376	175	50	%	%	NOUN
admet-376	175	51	)	)	PUNCT
admet-376	175	52	0.65	0.65	NUM
admet-376	175	53	486	486	NUM
admet-376	175	54	(	(	PUNCT
admet-376	175	55	35.2	35.2	NUM
admet-376	175	56	%	%	NOUN
admet-376	175	57	)	)	PUNCT
admet-376	175	58	1289	1289	NUM
admet-376	175	59	(	(	PUNCT
admet-376	175	60	93.3	93.3	NUM
admet-376	175	61	%	%	NOUN
admet-376	175	62	)	)	PUNCT
admet-376	175	63	0.7	0.7	NUM
admet-376	175	64	322	322	NUM
admet-376	175	65	(	(	PUNCT
admet-376	175	66	23.3	23.3	NUM
admet-376	175	67	%	%	NOUN
admet-376	175	68	)	)	PUNCT
admet-376	175	69	1113	1113	NUM
admet-376	175	70	(	(	PUNCT
admet-376	175	71	80.6	80.6	NUM
admet-376	175	72	%	%	NOUN
admet-376	175	73	)	)	PUNCT
admet-376	175	74	0.75	0.75	NUM
admet-376	175	75	201	201	NUM
admet-376	175	76	(	(	PUNCT
admet-376	175	77	14.6	14.6	NUM
admet-376	175	78	%	%	NOUN
admet-376	175	79	)	)	PUNCT
admet-376	175	80	830	830	NUM
admet-376	175	81	(	(	PUNCT
admet-376	175	82	60.1	60.1	NUM
admet-376	175	83	%	%	NOUN
admet-376	175	84	)	)	PUNCT
admet-376	175	85	0.8	0.8	NUM
admet-376	175	86	138	138	NUM
admet-376	175	87	(	(	PUNCT
admet-376	175	88	10.0	10.0	NUM
admet-376	175	89	%	%	NOUN
admet-376	175	90	)	)	PUNCT
admet-376	176	1	614	614	NUM
admet-376	176	2	(	(	PUNCT
admet-376	176	3	44.5	44.5	NUM
admet-376	176	4	%	%	NOUN
admet-376	176	5	)	)	PUNCT
admet-376	176	6	0.85	0.85	NUM
admet-376	176	7	93	93	NUM
admet-376	176	8	(	(	PUNCT
admet-376	176	9	6.7	6.7	NUM
admet-376	176	10	%	%	NOUN
admet-376	176	11	)	)	PUNCT
admet-376	176	12	447	447	NUM
admet-376	176	13	(	(	PUNCT
admet-376	176	14	32.4	32.4	NUM
admet-376	176	15	%	%	NOUN
admet-376	176	16	)	)	PUNCT
admet-376	176	17	0.9	0.9	NUM
admet-376	176	18	53	53	NUM
admet-376	176	19	(	(	PUNCT
admet-376	176	20	3.8	3.8	NUM
admet-376	176	21	%	%	NOUN
admet-376	176	22	)	)	PUNCT
admet-376	176	23	314	314	NUM
admet-376	176	24	(	(	PUNCT
admet-376	176	25	22.7	22.7	NUM
admet-376	176	26	%	%	NOUN
admet-376	176	27	)	)	PUNCT
admet-376	176	28	one	one	NUM
admet-376	176	29	obvious	obvious	ADJ
admet-376	176	30	point	point	NOUN
admet-376	176	31	is	be	AUX
admet-376	176	32	that	that	SCONJ
admet-376	176	33	the	the	DET
admet-376	176	34	number	number	NOUN
admet-376	176	35	of	of	ADP
admet-376	176	36	molecules	molecule	NOUN
admet-376	176	37	in	in	ADP
admet-376	176	38	the	the	DET
admet-376	176	39	cleaned	clean	VERB
admet-376	176	40	unpd	unpd	NOUN
admet-376	176	41	is	be	AUX
admet-376	176	42	roughly	roughly	ADV
admet-376	176	43	100x	100x	NUM
admet-376	176	44	greater	great	ADJ
admet-376	176	45	than	than	ADP
admet-376	176	46	the	the	DET
admet-376	176	47	number	number	NOUN
admet-376	176	48	of	of	ADP
admet-376	176	49	those	those	PRON
admet-376	176	50	in	in	ADP
admet-376	176	51	recon2	recon2	NOUN
admet-376	176	52	,	,	PUNCT
admet-376	176	53	so	so	SCONJ
admet-376	176	54	it	it	PRON
admet-376	176	55	could	could	AUX
admet-376	176	56	be	be	AUX
admet-376	176	57	argued	argue	VERB
admet-376	176	58	that	that	SCONJ
admet-376	176	59	this	this	DET
admet-376	176	60	alone	alone	ADJ
admet-376	176	61	means	mean	VERB
admet-376	176	62	statistically	statistically	ADV
admet-376	176	63	that	that	SCONJ
admet-376	176	64	there	there	PRON
admet-376	176	65	is	be	VERB
admet-376	176	66	simply	simply	ADV
admet-376	176	67	a	a	DET
admet-376	176	68	greater	great	ADJ
admet-376	176	69	likelihood	likelihood	NOUN
admet-376	176	70	of	of	ADP
admet-376	176	71	finding	find	VERB
admet-376	176	72	a	a	DET
admet-376	176	73	‘	'	PUNCT
admet-376	176	74	closer	close	ADJ
admet-376	176	75	’	'	PUNCT
admet-376	176	76	molecule	molecule	NOUN
admet-376	176	77	.	.	PUNCT
admet-376	177	1	while	while	SCONJ
admet-376	177	2	true	true	ADJ
admet-376	177	3	,	,	PUNCT
admet-376	177	4	this	this	PRON
admet-376	177	5	ignores	ignore	VERB
admet-376	177	6	the	the	DET
admet-376	177	7	biology	biology	NOUN
admet-376	177	8	(	(	PUNCT
admet-376	177	9	and	and	CCONJ
admet-376	177	10	the	the	DET
admet-376	177	11	fact	fact	NOUN
admet-376	177	12	is	be	AUX
admet-376	177	13	that	that	SCONJ
admet-376	177	14	we	we	PRON
admet-376	177	15	did	do	AUX
admet-376	177	16	find	find	VERB
admet-376	177	17	massively	massively	ADV
admet-376	177	18	more	more	ADV
admet-376	177	19	structurally	structurally	ADV
admet-376	177	20	close	close	ADJ
admet-376	177	21	natural	natural	ADJ
admet-376	177	22	products	product	NOUN
admet-376	177	23	than	than	ADP
admet-376	177	24	endogenites	endogenite	NOUN
admet-376	177	25	for	for	ADP
admet-376	177	26	a	a	DET
admet-376	177	27	given	give	VERB
admet-376	177	28	drug	drug	NOUN
admet-376	177	29	)	)	PUNCT
admet-376	177	30	,	,	PUNCT
admet-376	177	31	but	but	CCONJ
admet-376	177	32	we	we	PRON
admet-376	177	33	report	report	VERB
admet-376	177	34	both	both	DET
admet-376	177	35	analyses	analysis	NOUN
admet-376	177	36	.	.	PUNCT
admet-376	178	1	thus	thus	ADV
admet-376	178	2	,	,	PUNCT
admet-376	178	3	figure	figure	NOUN
admet-376	178	4	6b	6b	PROPN
admet-376	178	5	shows	show	VERB
admet-376	178	6	the	the	DET
admet-376	178	7	same	same	ADJ
admet-376	178	8	comparison	comparison	NOUN
admet-376	178	9	as	as	ADP
admet-376	178	10	that	that	PRON
admet-376	178	11	of	of	ADP
admet-376	178	12	figure	figure	NOUN
admet-376	178	13	6a	6a	NOUN
admet-376	178	14	save	save	VERB
admet-376	178	15	that	that	SCONJ
admet-376	178	16	the	the	DET
admet-376	178	17	unpd	unpd	NOUN
admet-376	178	18	molecules	molecule	NOUN
admet-376	178	19	are	be	AUX
admet-376	178	20	sampled	sample	VERB
admet-376	178	21	so	so	ADV
admet-376	178	22	as	as	SCONJ
admet-376	178	23	to	to	PART
admet-376	178	24	be	be	AUX
admet-376	178	25	numerically	numerically	ADV
admet-376	178	26	equal	equal	ADJ
admet-376	178	27	to	to	ADP
admet-376	178	28	those	those	PRON
admet-376	178	29	of	of	ADP
admet-376	178	30	recon2	recon2	NOUN
admet-376	178	31	,	,	PUNCT
admet-376	178	32	and	and	CCONJ
admet-376	178	33	to	to	PART
admet-376	178	34	share	share	VERB
admet-376	178	35	its	its	PRON
admet-376	178	36	distribution	distribution	NOUN
admet-376	178	37	of	of	ADP
admet-376	178	38	the	the	DET
admet-376	178	39	four	four	NUM
admet-376	178	40	molecular	molecular	ADJ
admet-376	178	41	properties	property	NOUN
admet-376	178	42	shown	show	VERB
admet-376	178	43	in	in	ADP
admet-376	178	44	figure	figure	NOUN
admet-376	178	45	1	1	NUM
admet-376	178	46	.	.	PUNCT
admet-376	179	1	in	in	ADP
admet-376	179	2	this	this	DET
admet-376	179	3	case	case	NOUN
admet-376	179	4	,	,	PUNCT
admet-376	179	5	the	the	DET
admet-376	179	6	‘	'	PUNCT
admet-376	179	7	advantage	advantage	NOUN
admet-376	179	8	’	'	PUNCT
admet-376	179	9	of	of	ADP
admet-376	179	10	unpd	unpd	NOUN
admet-376	179	11	is	be	AUX
admet-376	179	12	clearly	clearly	ADV
admet-376	179	13	diminished	diminish	VERB
admet-376	179	14	,	,	PUNCT
admet-376	179	15	albeit	albeit	SCONJ
admet-376	179	16	still	still	ADV
admet-376	179	17	substantial	substantial	ADJ
admet-376	179	18	,	,	PUNCT
admet-376	179	19	with	with	ADP
admet-376	179	20	70	70	NUM
admet-376	179	21	,	,	PUNCT
admet-376	179	22	124	124	NUM
admet-376	179	23	,	,	PUNCT
admet-376	179	24	197	197	NUM
admet-376	179	25	,	,	PUNCT
admet-376	179	26	282	282	NUM
admet-376	179	27	and	and	CCONJ
admet-376	179	28	417	417	NUM
admet-376	179	29	molecules	molecule	NOUN
admet-376	179	30	with	with	ADP
admet-376	179	31	a	a	DET
admet-376	179	32	ts	ts	X
admet-376	179	33	>	>	X
admet-376	179	34	0.9	0.9	NUM
admet-376	179	35	,	,	PUNCT
admet-376	179	36	0.85	0.85	NUM
admet-376	179	37	,	,	PUNCT
admet-376	179	38	0.8	0.8	NUM
admet-376	179	39	,	,	PUNCT
admet-376	179	40	0.75	0.75	NUM
admet-376	179	41	and	and	CCONJ
admet-376	179	42	0.7	0.7	NUM
admet-376	179	43	for	for	ADP
admet-376	179	44	unpd	unpd	NOUN
admet-376	179	45	,	,	PUNCT
admet-376	179	46	but	but	CCONJ
admet-376	179	47	only	only	ADV
admet-376	179	48	57	57	NUM
admet-376	179	49	,	,	PUNCT
admet-376	179	50	93	93	NUM
admet-376	179	51	,	,	PUNCT
admet-376	179	52	130	130	NUM
admet-376	179	53	,	,	PUNCT
admet-376	179	54	209	209	NUM
admet-376	179	55	and	and	CCONJ
admet-376	179	56	329	329	NUM
admet-376	179	57	equivalently	equivalently	ADV
admet-376	179	58	for	for	ADP
admet-376	179	59	recon2	recon2	NOUN
admet-376	179	60	.	.	PUNCT
admet-376	180	1	thus	thus	ADV
admet-376	180	2	for	for	ADP
admet-376	180	3	some	some	DET
admet-376	180	4	values	value	NOUN
admet-376	180	5	of	of	ADP
admet-376	180	6	ts	ts	PROPN
admet-376	180	7	,	,	PUNCT
admet-376	180	8	unpd	unpd	NOUN
admet-376	180	9	can	can	AUX
admet-376	180	10	enjoy	enjoy	VERB
admet-376	180	11	a	a	DET
admet-376	180	12	50	50	NUM
admet-376	180	13	%	%	NOUN
admet-376	180	14	advantage	advantage	NOUN
admet-376	180	15	over	over	ADP
admet-376	180	16	recon2	recon2	NOUN
admet-376	180	17	even	even	ADV
admet-376	180	18	when	when	SCONJ
admet-376	180	19	comparisons	comparison	NOUN
admet-376	180	20	are	be	AUX
admet-376	180	21	strictly	strictly	ADV
admet-376	180	22	scaled	scale	VERB
admet-376	180	23	to	to	ADP
admet-376	180	24	numbers	number	NOUN
admet-376	180	25	,	,	PUNCT
admet-376	180	26	whatever	whatever	PRON
admet-376	180	27	the	the	DET
admet-376	180	28	biology	biology	NOUN
admet-376	180	29	.	.	PUNCT
admet-376	181	1	we	we	PRON
admet-376	181	2	also	also	ADV
admet-376	181	3	ran	run	VERB
admet-376	181	4	the	the	DET
admet-376	181	5	sampled	sample	VERB
admet-376	181	6	version	version	NOUN
admet-376	181	7	multiple	multiple	ADJ
admet-376	181	8	times	time	NOUN
admet-376	181	9	,	,	PUNCT
admet-376	181	10	to	to	PART
admet-376	181	11	look	look	VERB
admet-376	181	12	at	at	ADP
admet-376	181	13	the	the	DET
admet-376	181	14	‘	'	PUNCT
admet-376	181	15	range	range	NOUN
admet-376	181	16	’	'	PUNCT
admet-376	181	17	,	,	PUNCT
admet-376	181	18	but	but	CCONJ
admet-376	181	19	the	the	DET
admet-376	181	20	numbers	number	NOUN
admet-376	181	21	involved	involve	VERB
admet-376	181	22	were	be	AUX
admet-376	181	23	great	great	ADJ
admet-376	181	24	enough	enough	ADV
admet-376	181	25	that	that	SCONJ
admet-376	181	26	this	this	PRON
admet-376	181	27	made	make	VERB
admet-376	181	28	negligible	negligible	ADJ
admet-376	181	29	difference	difference	NOUN
admet-376	181	30	.	.	PUNCT
admet-376	182	1	note	note	VERB
admet-376	182	2	that	that	SCONJ
admet-376	182	3	recon2	recon2	NOUN
admet-376	182	4	does	do	AUX
admet-376	182	5	not	not	PART
admet-376	182	6	contain	contain	VERB
admet-376	182	7	the	the	DET
admet-376	182	8	thousands	thousand	NOUN
admet-376	182	9	of	of	ADP
admet-376	182	10	permutations	permutation	NOUN
admet-376	182	11	of	of	ADP
admet-376	182	12	triglycerides	triglyceride	NOUN
admet-376	182	13	and	and	CCONJ
admet-376	182	14	the	the	DET
admet-376	182	15	like	like	ADJ
admet-376	182	16	[	[	X
admet-376	182	17	137	137	NUM
admet-376	182	18	]	]	PUNCT
admet-376	182	19	,	,	PUNCT
admet-376	182	20	that	that	PRON
admet-376	182	21	would	would	AUX
admet-376	182	22	increase	increase	VERB
admet-376	182	23	its	its	PRON
admet-376	182	24	size	size	NOUN
admet-376	182	25	substantially	substantially	ADV
admet-376	182	26	but	but	CCONJ
admet-376	182	27	not	not	PART
admet-376	182	28	provide	provide	VERB
admet-376	182	29	significantly	significantly	ADV
admet-376	182	30	better	well	ADJ
admet-376	182	31	hits	hit	NOUN
admet-376	182	32	(	(	PUNCT
admet-376	182	33	i.e.	i.e.	X
admet-376	182	34	the	the	DET
admet-376	182	35	‘	'	PUNCT
admet-376	182	36	100x	100x	NUM
admet-376	182	37	’	'	PUNCT
admet-376	182	38	figure	figure	NOUN
admet-376	182	39	above	above	ADV
admet-376	182	40	is	be	AUX
admet-376	182	41	rather	rather	ADV
admet-376	182	42	a	a	DET
admet-376	182	43	substantial	substantial	ADJ
admet-376	182	44	overestimate	overestimate	NOUN
admet-376	182	45	of	of	ADP
admet-376	182	46	the	the	DET
admet-376	182	47	differences	difference	NOUN
admet-376	182	48	in	in	ADP
admet-376	182	49	true	true	ADJ
admet-376	182	50	size	size	NOUN
admet-376	182	51	)	)	PUNCT
admet-376	182	52	,	,	PUNCT
admet-376	182	53	and	and	CCONJ
admet-376	182	54	we	we	PRON
admet-376	182	55	also	also	ADV
admet-376	182	56	know	know	VERB
admet-376	182	57	of	of	ADP
admet-376	182	58	many	many	ADJ
admet-376	182	59	more	more	ADJ
admet-376	182	60	endogenites	endogenite	NOUN
admet-376	182	61	that	that	PRON
admet-376	182	62	are	be	AUX
admet-376	182	63	not	not	PART
admet-376	182	64	yet	yet	ADV
admet-376	182	65	in	in	ADP
admet-376	182	66	recon2	recon2	NOUN
admet-376	182	67	(	(	PUNCT
admet-376	182	68	see	see	VERB
admet-376	182	69	e.g.	e.g.	ADV
admet-376	182	70	[	[	X
admet-376	182	71	9	9	NUM
admet-376	182	72	]	]	SYM
admet-376	182	73	)	)	PUNCT
admet-376	182	74	.	.	PUNCT
admet-376	183	1	figure	figure	NOUN
admet-376	183	2	7a	7a	NOUN
admet-376	183	3	shows	show	VERB
admet-376	183	4	a	a	DET
admet-376	183	5	similar	similar	ADJ
admet-376	183	6	comparison	comparison	NOUN
admet-376	183	7	for	for	ADP
admet-376	183	8	the	the	DET
admet-376	183	9	natural	natural	ADJ
admet-376	183	10	products	product	NOUN
admet-376	183	11	in	in	ADP
admet-376	183	12	a	a	DET
admet-376	183	13	cleaned	clean	VERB
admet-376	183	14	-	-	PUNCT
admet-376	183	15	up	up	ADP
admet-376	183	16	version	version	NOUN
admet-376	183	17	(	(	PUNCT
admet-376	183	18	see	see	VERB
admet-376	183	19	materials	material	NOUN
admet-376	183	20	admet	admet	X
admet-376	183	21	&	&	CCONJ
admet-376	183	22	dmpk	dmpk	PROPN
admet-376	183	23	5(2	5(2	NUM
admet-376	183	24	)	)	PUNCT
admet-376	183	25	(	(	PUNCT
admet-376	183	26	2017	2017	NUM
admet-376	183	27	)	)	PUNCT
admet-376	183	28	85	85	NUM
admet-376	183	29	-	-	SYM
admet-376	183	30	125	125	NUM
admet-376	183	31	exogenous	exogenous	ADJ
admet-376	183	32	natural	natural	ADJ
admet-376	183	33	products	product	NOUN
admet-376	183	34	as	as	ADP
admet-376	183	35	‘	'	PUNCT
admet-376	183	36	natural	natural	ADJ
admet-376	183	37	’	'	PUNCT
admet-376	183	38	drug	drug	NOUN
admet-376	183	39	transporter	transporter	NOUN
admet-376	183	40	substrates	substrate	VERB
admet-376	183	41	doi	doi	NOUN
admet-376	183	42	:	:	PUNCT
admet-376	183	43	10.5599	10.5599	NUM
admet-376	183	44	/	/	SYM
admet-376	183	45	admet.5.2.376	admet.5.2.376	PROPN
admet-376	183	46	105	105	NUM
admet-376	183	47	and	and	CCONJ
admet-376	183	48	methods	method	NOUN
admet-376	183	49	)	)	PUNCT
admet-376	183	50	of	of	ADP
admet-376	183	51	the	the	DET
admet-376	183	52	dictionary	dictionary	NOUN
admet-376	183	53	of	of	ADP
admet-376	183	54	natural	natural	ADJ
admet-376	183	55	products	product	NOUN
admet-376	183	56	(	(	PUNCT
admet-376	183	57	dnp	dnp	PROPN
admet-376	183	58	)	)	PUNCT
admet-376	184	1	[	[	X
admet-376	184	2	126	126	NUM
admet-376	184	3	]	]	PUNCT
admet-376	184	4	,	,	PUNCT
admet-376	184	5	seen	see	VERB
admet-376	184	6	as	as	ADP
admet-376	184	7	a	a	DET
admet-376	184	8	fair	fair	ADJ
admet-376	184	9	comparison	comparison	NOUN
admet-376	184	10	[	[	X
admet-376	184	11	138	138	NUM
admet-376	184	12	]	]	PUNCT
admet-376	184	13	,	,	PUNCT
admet-376	184	14	and	and	CCONJ
admet-376	184	15	again	again	ADV
admet-376	184	16	using	use	VERB
admet-376	184	17	the	the	DET
admet-376	184	18	maccs	maccs	PROPN
admet-376	184	19	encoding	encoding	NOUN
admet-376	184	20	.	.	PUNCT
admet-376	185	1	our	our	PRON
admet-376	185	2	cleaned	clean	VERB
admet-376	185	3	dnp	dnp	PROPN
admet-376	185	4	(	(	PUNCT
admet-376	185	5	with	with	ADP
admet-376	185	6	marketed	market	VERB
admet-376	185	7	drugs	drug	NOUN
admet-376	185	8	,	,	PUNCT
admet-376	185	9	endogenites	endogenite	NOUN
admet-376	185	10	and	and	CCONJ
admet-376	185	11	duplicates	duplicate	NOUN
admet-376	185	12	removed	remove	VERB
admet-376	185	13	)	)	PUNCT
admet-376	185	14	contains	contain	VERB
admet-376	185	15	72,442	72,442	NUM
admet-376	185	16	molecules	molecule	NOUN
admet-376	185	17	,	,	PUNCT
admet-376	185	18	including	include	VERB
admet-376	185	19	32,390	32,390	NUM
admet-376	185	20	that	that	PRON
admet-376	185	21	are	be	AUX
admet-376	185	22	already	already	ADV
admet-376	185	23	in	in	ADP
admet-376	185	24	unpd	unpd	NOUN
admet-376	185	25	(	(	PUNCT
admet-376	185	26	implying	imply	VERB
admet-376	185	27	41,228	41,228	NUM
admet-376	185	28	that	that	PRON
admet-376	185	29	are	be	AUX
admet-376	185	30	‘	'	PUNCT
admet-376	185	31	new	new	ADJ
admet-376	185	32	’	'	PUNCT
admet-376	185	33	,	,	PUNCT
admet-376	185	34	but	but	CCONJ
admet-376	185	35	also	also	ADV
admet-376	185	36	implying	imply	VERB
admet-376	185	37	123,443	123,443	NUM
admet-376	185	38	that	that	PRON
admet-376	185	39	are	be	AUX
admet-376	185	40	in	in	ADP
admet-376	185	41	our	our	PRON
admet-376	185	42	unpd	unpd	NOUN
admet-376	185	43	but	but	CCONJ
admet-376	185	44	not	not	PART
admet-376	185	45	in	in	ADP
admet-376	185	46	our	our	PRON
admet-376	185	47	dnp	dnp	PROPN
admet-376	185	48	)	)	PUNCT
admet-376	185	49	.	.	PUNCT
admet-376	186	1	here	here	ADV
admet-376	186	2	there	there	PRON
admet-376	186	3	are	be	VERB
admet-376	186	4	at	at	ADV
admet-376	186	5	least	least	ADV
admet-376	186	6	37	37	NUM
admet-376	186	7	%	%	NOUN
admet-376	186	8	of	of	ADP
admet-376	186	9	drugs	drug	NOUN
admet-376	186	10	that	that	PRON
admet-376	186	11	have	have	VERB
admet-376	186	12	a	a	DET
admet-376	186	13	ts	ts	ADV
admet-376	186	14	greater	great	ADJ
admet-376	186	15	than	than	ADP
admet-376	186	16	0.8	0.8	NUM
admet-376	186	17	to	to	ADP
admet-376	186	18	the	the	DET
admet-376	186	19	nearest	near	ADJ
admet-376	186	20	database	database	NOUN
admet-376	186	21	member	member	NOUN
admet-376	186	22	,	,	PUNCT
admet-376	186	23	and	and	CCONJ
admet-376	186	24	50	50	NUM
admet-376	186	25	%	%	NOUN
admet-376	186	26	have	have	VERB
admet-376	186	27	a	a	DET
admet-376	186	28	ts	ts	ADV
admet-376	186	29	greater	great	ADJ
admet-376	186	30	than	than	ADP
admet-376	186	31	0.75	0.75	NUM
admet-376	186	32	,	,	PUNCT
admet-376	186	33	contrasting	contrast	VERB
admet-376	186	34	with	with	ADP
admet-376	186	35	values	value	NOUN
admet-376	186	36	for	for	ADP
admet-376	186	37	recon2	recon2	NOUN
admet-376	186	38	of	of	ADP
admet-376	186	39	just	just	ADV
admet-376	186	40	10	10	NUM
admet-376	186	41	%	%	NOUN
admet-376	186	42	and	and	CCONJ
admet-376	186	43	15	15	NUM
admet-376	186	44	%	%	NOUN
admet-376	186	45	,	,	PUNCT
admet-376	186	46	respectively	respectively	ADV
admet-376	186	47	.	.	PUNCT
admet-376	187	1	these	these	DET
admet-376	187	2	findings	finding	NOUN
admet-376	187	3	are	be	AUX
admet-376	187	4	roughly	roughly	ADV
admet-376	187	5	similar	similar	ADJ
admet-376	187	6	to	to	ADP
admet-376	187	7	(	(	PUNCT
admet-376	187	8	but	but	CCONJ
admet-376	187	9	the	the	DET
admet-376	187	10	similarities	similarity	NOUN
admet-376	187	11	slightly	slightly	ADV
admet-376	187	12	lower	low	ADJ
admet-376	187	13	than	than	ADP
admet-376	187	14	)	)	PUNCT
admet-376	187	15	those	those	PRON
admet-376	187	16	from	from	ADP
admet-376	187	17	unpd	unpd	NOUN
admet-376	187	18	,	,	PUNCT
admet-376	187	19	indicating	indicate	VERB
admet-376	187	20	that	that	SCONJ
admet-376	187	21	at	at	ADP
admet-376	187	22	least	least	ADJ
admet-376	187	23	some	some	PRON
admet-376	187	24	‘	'	PUNCT
admet-376	187	25	winners	winner	NOUN
admet-376	187	26	’	'	PUNCT
admet-376	187	27	are	be	AUX
admet-376	187	28	unique	unique	ADJ
admet-376	187	29	to	to	ADP
admet-376	187	30	unpd	unpd	NOUN
admet-376	187	31	and	and	CCONJ
admet-376	187	32	some	some	PRON
admet-376	187	33	to	to	ADP
admet-376	187	34	dnp	dnp	PROPN
admet-376	187	35	.	.	PUNCT
admet-376	188	1	in	in	ADP
admet-376	188	2	a	a	DET
admet-376	188	3	similar	similar	ADJ
admet-376	188	4	vein	vein	NOUN
admet-376	188	5	,	,	PUNCT
admet-376	188	6	figure	figure	NOUN
admet-376	188	7	7b	7b	PROPN
admet-376	188	8	shows	show	VERB
admet-376	188	9	the	the	DET
admet-376	188	10	sampled	sample	VERB
admet-376	188	11	version	version	NOUN
admet-376	188	12	,	,	PUNCT
admet-376	188	13	with	with	ADP
admet-376	188	14	little	little	ADJ
admet-376	188	15	impact	impact	NOUN
admet-376	188	16	.	.	PUNCT
admet-376	189	1	figure	figure	NOUN
admet-376	189	2	7	7	NUM
admet-376	189	3	.	.	PUNCT
admet-376	189	4	relationship	relationship	NOUN
admet-376	189	5	between	between	ADP
admet-376	189	6	the	the	DET
admet-376	189	7	normalised	normalise	VERB
admet-376	189	8	rank	rank	NOUN
admet-376	189	9	order	order	NOUN
admet-376	189	10	of	of	ADP
admet-376	189	11	the	the	DET
admet-376	189	12	nearest	near	ADJ
admet-376	189	13	database	database	NOUN
admet-376	189	14	molecule	molecule	NOUN
admet-376	189	15	to	to	ADP
admet-376	189	16	marketed	market	VERB
admet-376	189	17	drugs	drug	NOUN
admet-376	189	18	for	for	ADP
admet-376	189	19	(	(	PUNCT
admet-376	189	20	red	red	PROPN
admet-376	189	21	)	)	PUNCT
admet-376	189	22	the	the	DET
admet-376	189	23	cleaned	clean	VERB
admet-376	189	24	version	version	NOUN
admet-376	189	25	of	of	ADP
admet-376	189	26	the	the	DET
admet-376	189	27	dictionary	dictionary	NOUN
admet-376	189	28	of	of	ADP
admet-376	189	29	natural	natural	ADJ
admet-376	189	30	products	product	NOUN
admet-376	189	31	(	(	PUNCT
admet-376	189	32	dnp	dnp	PROPN
admet-376	189	33	)	)	PUNCT
admet-376	190	1	[	[	X
admet-376	190	2	126	126	NUM
admet-376	190	3	]	]	PUNCT
admet-376	190	4	and	and	CCONJ
admet-376	190	5	(	(	PUNCT
admet-376	190	6	blue	blue	ADJ
admet-376	190	7	)	)	PUNCT
admet-376	190	8	recon2	recon2	NOUN
admet-376	190	9	.	.	PUNCT
admet-376	191	1	‘	'	PUNCT
admet-376	191	2	cleaning	clean	VERB
admet-376	191	3	’	'	PUNCT
admet-376	191	4	removed	remove	VERB
admet-376	191	5	duplicates	duplicate	NOUN
admet-376	191	6	as	as	ADV
admet-376	191	7	well	well	ADV
admet-376	191	8	as	as	ADP
admet-376	191	9	molecules	molecule	NOUN
admet-376	191	10	that	that	PRON
admet-376	191	11	were	be	AUX
admet-376	191	12	in	in	ADP
admet-376	191	13	either	either	DET
admet-376	191	14	recon2	recon2	NOUN
admet-376	191	15	or	or	CCONJ
admet-376	191	16	in	in	ADP
admet-376	191	17	the	the	DET
admet-376	191	18	list	list	NOUN
admet-376	191	19	of	of	ADP
admet-376	191	20	marketed	market	VERB
admet-376	191	21	drugs	drug	NOUN
admet-376	191	22	,	,	PUNCT
admet-376	191	23	both	both	PRON
admet-376	191	24	of	of	ADP
admet-376	191	25	which	which	PRON
admet-376	191	26	were	be	AUX
admet-376	191	27	precisely	precisely	ADV
admet-376	191	28	as	as	ADV
admet-376	191	29	described	describe	VERB
admet-376	191	30	and	and	CCONJ
admet-376	191	31	used	use	VERB
admet-376	191	32	previously	previously	ADV
admet-376	191	33	[	[	X
admet-376	191	34	22	22	NUM
admet-376	191	35	-	-	SYM
admet-376	191	36	24	24	NUM
admet-376	191	37	]	]	PUNCT
admet-376	191	38	.	.	PUNCT
admet-376	192	1	a.	a.	PROPN
admet-376	192	2	full	full	ADJ
admet-376	192	3	,	,	PUNCT
admet-376	192	4	cleaned	clean	VERB
admet-376	192	5	version	version	NOUN
admet-376	192	6	of	of	ADP
admet-376	192	7	dnp	dnp	PROPN
admet-376	192	8	.	.	PROPN
admet-376	192	9	b.	b.	PROPN
admet-376	193	1	a	a	DET
admet-376	193	2	sampled	sample	VERB
admet-376	193	3	version	version	NOUN
admet-376	193	4	of	of	ADP
admet-376	193	5	dnp	dnp	PROPN
admet-376	193	6	using	use	VERB
admet-376	193	7	the	the	DET
admet-376	193	8	same	same	ADJ
admet-376	193	9	number	number	NOUN
admet-376	193	10	of	of	ADP
admet-376	193	11	molecules	molecule	NOUN
admet-376	193	12	as	as	ADP
admet-376	193	13	those	those	PRON
admet-376	193	14	in	in	ADP
admet-376	193	15	recon2	recon2	NOUN
admet-376	193	16	sampled	sample	VERB
admet-376	193	17	as	as	ADP
admet-376	193	18	per	per	ADP
admet-376	193	19	the	the	DET
admet-376	193	20	distribution	distribution	NOUN
admet-376	193	21	of	of	ADP
admet-376	193	22	the	the	DET
admet-376	193	23	properties	property	NOUN
admet-376	193	24	in	in	ADP
admet-376	193	25	figure	figure	NOUN
admet-376	193	26	5	5	NUM
admet-376	193	27	.	.	PUNCT
admet-376	193	28	figure	figure	NOUN
admet-376	193	29	8	8	NUM
admet-376	193	30	shows	show	VERB
admet-376	193	31	the	the	DET
admet-376	193	32	effects	effect	NOUN
admet-376	193	33	of	of	ADP
admet-376	193	34	cleaning	cleaning	NOUN
admet-376	193	35	and	and	CCONJ
admet-376	193	36	the	the	DET
admet-376	193	37	degree	degree	NOUN
admet-376	193	38	of	of	ADP
admet-376	193	39	overlap	overlap	NOUN
admet-376	193	40	of	of	ADP
admet-376	193	41	molecules	molecule	NOUN
admet-376	193	42	in	in	ADP
admet-376	193	43	our	our	PRON
admet-376	193	44	cleaned	clean	VERB
admet-376	193	45	versions	version	NOUN
admet-376	193	46	of	of	ADP
admet-376	193	47	unpd	unpd	NOUN
admet-376	193	48	and	and	CCONJ
admet-376	193	49	dnp	dnp	PROPN
admet-376	193	50	.	.	PROPN
admet-376	193	51	figure	figure	PROPN
admet-376	193	52	8	8	NUM
admet-376	193	53	.	.	PUNCT
admet-376	194	1	overlaps	overlap	NOUN
admet-376	194	2	between	between	ADP
admet-376	194	3	unpd	unpd	NOUN
admet-376	194	4	and	and	CCONJ
admet-376	194	5	dnp	dnp	PROPN
admet-376	194	6	databases	database	NOUN
admet-376	194	7	.	.	PUNCT
admet-376	195	1	‘	'	PUNCT
admet-376	195	2	cleaning	clean	VERB
admet-376	195	3	’	'	PUNCT
admet-376	195	4	removed	remove	VERB
admet-376	195	5	duplicates	duplicate	NOUN
admet-376	195	6	as	as	ADV
admet-376	195	7	well	well	ADV
admet-376	195	8	as	as	ADP
admet-376	195	9	molecules	molecule	NOUN
admet-376	195	10	that	that	PRON
admet-376	195	11	were	be	AUX
admet-376	195	12	in	in	ADP
admet-376	195	13	either	either	DET
admet-376	195	14	recon2	recon2	NOUN
admet-376	195	15	or	or	CCONJ
admet-376	195	16	in	in	ADP
admet-376	195	17	the	the	DET
admet-376	195	18	list	list	NOUN
admet-376	195	19	of	of	ADP
admet-376	195	20	marketed	market	VERB
admet-376	195	21	drugs	drug	NOUN
admet-376	195	22	,	,	PUNCT
admet-376	195	23	both	both	PRON
admet-376	195	24	of	of	ADP
admet-376	195	25	which	which	PRON
admet-376	195	26	were	be	AUX
admet-376	195	27	precisely	precisely	ADV
admet-376	195	28	as	as	ADV
admet-376	195	29	described	describe	VERB
admet-376	195	30	and	and	CCONJ
admet-376	195	31	used	use	VERB
admet-376	195	32	previously	previously	ADV
admet-376	195	33	[	[	X
admet-376	195	34	22	22	NUM
admet-376	195	35	-	-	SYM
admet-376	195	36	24	24	NUM
admet-376	195	37	]	]	PUNCT
admet-376	195	38	.	.	PUNCT
admet-376	195	39	o'hagan	o'hagan	PROPN
admet-376	195	40	&	&	CCONJ
admet-376	195	41	kell	kell	PROPN
admet-376	195	42	admet	admet	PROPN
admet-376	195	43	&	&	CCONJ
admet-376	195	44	dmpk	dmpk	PROPN
admet-376	195	45	5(2	5(2	NUM
admet-376	195	46	)	)	PUNCT
admet-376	195	47	(	(	PUNCT
admet-376	195	48	2017	2017	NUM
admet-376	195	49	)	)	PUNCT
admet-376	195	50	85	85	NUM
admet-376	195	51	-	-	SYM
admet-376	195	52	125	125	NUM
admet-376	195	53	106	106	NUM
admet-376	195	54	the	the	DET
admet-376	195	55	zinc	zinc	NOUN
admet-376	195	56	database	database	NOUN
admet-376	196	1	[	[	X
admet-376	196	2	124	124	NUM
admet-376	196	3	]	]	PUNCT
admet-376	196	4	includes	include	VERB
admet-376	196	5	a	a	DET
admet-376	196	6	very	very	ADV
admet-376	196	7	large	large	ADJ
admet-376	196	8	number	number	NOUN
admet-376	196	9	(	(	PUNCT
admet-376	196	10	ca	ca	PROPN
admet-376	196	11	16	16	NUM
admet-376	196	12	m	m	NOUN
admet-376	196	13	)	)	PUNCT
admet-376	196	14	and	and	CCONJ
admet-376	196	15	variety	variety	NOUN
admet-376	196	16	of	of	ADP
admet-376	196	17	synthetic	synthetic	ADJ
admet-376	196	18	molecules	molecule	NOUN
admet-376	196	19	.	.	PUNCT
admet-376	197	1	as	as	ADP
admet-376	197	2	usual	usual	ADJ
admet-376	197	3	,	,	PUNCT
admet-376	197	4	we	we	PRON
admet-376	197	5	cleaned	clean	VERB
admet-376	197	6	it	it	PRON
admet-376	197	7	to	to	PART
admet-376	197	8	remove	remove	VERB
admet-376	197	9	any	any	DET
admet-376	197	10	molecules	molecule	NOUN
admet-376	197	11	that	that	PRON
admet-376	197	12	were	be	AUX
admet-376	197	13	marketed	market	VERB
admet-376	197	14	drugs	drug	NOUN
admet-376	197	15	or	or	CCONJ
admet-376	197	16	recon	recon	NOUN
admet-376	197	17	2	2	NUM
admet-376	197	18	metabolites	metabolite	NOUN
admet-376	197	19	,	,	PUNCT
admet-376	197	20	and	and	CCONJ
admet-376	197	21	ran	run	VERB
admet-376	197	22	it	it	PRON
admet-376	197	23	(	(	PUNCT
admet-376	197	24	and	and	CCONJ
admet-376	197	25	recon	recon	NOUN
admet-376	197	26	2	2	NUM
admet-376	197	27	)	)	PUNCT
admet-376	197	28	against	against	ADP
admet-376	197	29	drugs	drug	NOUN
admet-376	197	30	as	as	ADP
admet-376	197	31	above	above	ADV
admet-376	197	32	.	.	PUNCT
admet-376	198	1	this	this	DET
admet-376	198	2	time	time	NOUN
admet-376	198	3	we	we	PRON
admet-376	198	4	ran	run	VERB
admet-376	198	5	it	it	PRON
admet-376	198	6	as	as	ADP
admet-376	198	7	50	50	NUM
admet-376	198	8	subsets	subset	NOUN
admet-376	198	9	,	,	PUNCT
admet-376	198	10	each	each	PRON
admet-376	198	11	of	of	ADP
admet-376	198	12	some	some	DET
admet-376	198	13	148,000	148,000	NUM
admet-376	198	14	,	,	PUNCT
admet-376	198	15	to	to	PART
admet-376	198	16	show	show	VERB
admet-376	198	17	the	the	DET
admet-376	198	18	range	range	NOUN
admet-376	198	19	of	of	ADP
admet-376	198	20	curves	curve	NOUN
admet-376	198	21	that	that	SCONJ
admet-376	198	22	we	we	PRON
admet-376	198	23	could	could	AUX
admet-376	198	24	get	get	VERB
admet-376	198	25	.	.	PUNCT
admet-376	199	1	thus	thus	ADV
admet-376	199	2	the	the	DET
admet-376	199	3	percentage	percentage	NOUN
admet-376	199	4	of	of	ADP
admet-376	199	5	zinc	zinc	NOUN
admet-376	199	6	samples	sample	NOUN
admet-376	199	7	that	that	PRON
admet-376	199	8	had	have	VERB
admet-376	199	9	a	a	DET
admet-376	199	10	member	member	NOUN
admet-376	199	11	that	that	PRON
admet-376	199	12	was	be	AUX
admet-376	199	13	within	within	ADP
admet-376	199	14	a	a	DET
admet-376	199	15	ts	ts	NOUN
admet-376	199	16	of	of	ADP
admet-376	199	17	0.8	0.8	NUM
admet-376	199	18	to	to	ADP
admet-376	199	19	drugs	drug	NOUN
admet-376	199	20	is	be	AUX
admet-376	199	21	between	between	ADP
admet-376	199	22	35	35	NUM
admet-376	199	23	and	and	CCONJ
admet-376	199	24	45	45	NUM
admet-376	199	25	%	%	NOUN
admet-376	199	26	depending	depend	VERB
admet-376	199	27	on	on	ADP
admet-376	199	28	the	the	DET
admet-376	199	29	sample	sample	NOUN
admet-376	199	30	,	,	PUNCT
admet-376	199	31	while	while	SCONJ
admet-376	199	32	that	that	PRON
admet-376	199	33	for	for	ADP
admet-376	199	34	a	a	DET
admet-376	199	35	ts	ts	NOUN
admet-376	199	36	of	of	ADP
admet-376	199	37	0.75	0.75	NUM
admet-376	199	38	or	or	CCONJ
admet-376	199	39	greater	great	ADJ
admet-376	199	40	varied	varied	ADJ
admet-376	199	41	from	from	ADP
admet-376	199	42	0.59	0.59	NUM
admet-376	199	43	to	to	ADP
admet-376	199	44	0.74	0.74	NUM
admet-376	199	45	.	.	PUNCT
admet-376	200	1	this	this	PRON
admet-376	200	2	implies	imply	VERB
admet-376	200	3	a	a	DET
admet-376	200	4	considerably	considerably	ADV
admet-376	200	5	greater	great	ADJ
admet-376	200	6	variation	variation	NOUN
admet-376	200	7	than	than	ADP
admet-376	200	8	that	that	PRON
admet-376	200	9	for	for	ADP
admet-376	200	10	the	the	DET
admet-376	200	11	natural	natural	ADJ
admet-376	200	12	products	product	NOUN
admet-376	200	13	.	.	PUNCT
admet-376	201	1	figure	figure	NOUN
admet-376	201	2	9	9	NUM
admet-376	201	3	.	.	PUNCT
admet-376	201	4	zinc	zinc	NOUN
admet-376	201	5	database	database	NOUN
admet-376	201	6	.	.	PUNCT
admet-376	202	1	relationship	relationship	NOUN
admet-376	202	2	between	between	ADP
admet-376	202	3	the	the	DET
admet-376	202	4	normalised	normalise	VERB
admet-376	202	5	rank	rank	NOUN
admet-376	202	6	order	order	NOUN
admet-376	202	7	of	of	ADP
admet-376	202	8	the	the	DET
admet-376	202	9	nearest	near	ADJ
admet-376	202	10	database	database	NOUN
admet-376	202	11	molecule	molecule	NOUN
admet-376	202	12	to	to	ADP
admet-376	202	13	marketed	market	VERB
admet-376	202	14	drugs	drug	NOUN
admet-376	202	15	for	for	ADP
admet-376	202	16	the	the	DET
admet-376	202	17	zinc	zinc	NOUN
admet-376	202	18	database	database	NOUN
admet-376	202	19	(	(	PUNCT
admet-376	202	20	zinc	zinc	NOUN
admet-376	202	21	)	)	PUNCT
admet-376	203	1	[	[	X
admet-376	203	2	124	124	NUM
admet-376	203	3	]	]	X
admet-376	203	4	(	(	PUNCT
admet-376	203	5	red	red	ADJ
admet-376	203	6	)	)	PUNCT
admet-376	203	7	and	and	CCONJ
admet-376	203	8	recon	recon	PROPN
admet-376	203	9	2	2	NUM
admet-376	203	10	(	(	PUNCT
admet-376	203	11	blue	blue	NOUN
admet-376	203	12	)	)	PUNCT
admet-376	203	13	.	.	PUNCT
admet-376	204	1	the	the	DET
admet-376	204	2	zinc	zinc	NOUN
admet-376	204	3	database	database	NOUN
admet-376	204	4	was	be	AUX
admet-376	204	5	‘	'	PUNCT
admet-376	204	6	cleaned	clean	VERB
admet-376	204	7	’	'	PUNCT
admet-376	204	8	to	to	PART
admet-376	204	9	remove	remove	VERB
admet-376	204	10	molecules	molecule	NOUN
admet-376	204	11	that	that	PRON
admet-376	204	12	were	be	AUX
admet-376	204	13	in	in	ADP
admet-376	204	14	either	either	DET
admet-376	204	15	recon2	recon2	NOUN
admet-376	204	16	or	or	CCONJ
admet-376	204	17	in	in	ADP
admet-376	204	18	the	the	DET
admet-376	204	19	list	list	NOUN
admet-376	204	20	of	of	ADP
admet-376	204	21	marketed	market	VERB
admet-376	204	22	drugs	drug	NOUN
admet-376	204	23	.	.	PUNCT
admet-376	205	1	another	another	DET
admet-376	205	2	source	source	NOUN
admet-376	205	3	of	of	ADP
admet-376	205	4	candidate	candidate	NOUN
admet-376	205	5	transporter	transporter	NOUN
admet-376	205	6	substrates	substrate	NOUN
admet-376	205	7	was	be	AUX
admet-376	205	8	the	the	DET
admet-376	205	9	list	list	NOUN
admet-376	205	10	of	of	ADP
admet-376	205	11	molecules	molecule	NOUN
admet-376	205	12	observed	observe	VERB
admet-376	205	13	in	in	ADP
admet-376	205	14	serum	serum	NOUN
admet-376	205	15	as	as	ADV
admet-376	205	16	catalogued	catalogue	VERB
admet-376	205	17	at	at	ADP
admet-376	205	18	http://www.serummetabolome.ca/	http://www.serummetabolome.ca/	NUM
admet-376	205	19	,	,	PUNCT
admet-376	205	20	on	on	ADP
admet-376	205	21	the	the	DET
admet-376	205	22	grounds	ground	NOUN
admet-376	205	23	that	that	SCONJ
admet-376	205	24	if	if	SCONJ
admet-376	205	25	they	they	PRON
admet-376	205	26	had	have	AUX
admet-376	205	27	reached	reach	VERB
admet-376	205	28	the	the	DET
admet-376	205	29	bloodstream	bloodstream	NOUN
admet-376	205	30	they	they	PRON
admet-376	205	31	must	must	AUX
admet-376	205	32	have	have	AUX
admet-376	205	33	been	be	AUX
admet-376	205	34	transported	transport	VERB
admet-376	205	35	there	there	ADV
admet-376	205	36	.	.	PUNCT
admet-376	206	1	we	we	PRON
admet-376	206	2	produced	produce	VERB
admet-376	206	3	a	a	DET
admet-376	206	4	version	version	NOUN
admet-376	206	5	of	of	ADP
admet-376	206	6	this	this	PRON
admet-376	206	7	that	that	PRON
admet-376	206	8	again	again	ADV
admet-376	206	9	lacked	lack	VERB
admet-376	206	10	all	all	PRON
admet-376	206	11	marketed	market	VERB
admet-376	206	12	drugs	drug	NOUN
admet-376	206	13	and	and	CCONJ
admet-376	206	14	recon2	recon2	NOUN
admet-376	206	15	metabolites	metabolite	NOUN
admet-376	206	16	,	,	PUNCT
admet-376	206	17	amounting	amount	VERB
admet-376	206	18	to	to	ADP
admet-376	206	19	some	some	DET
admet-376	206	20	1480	1480	NUM
admet-376	206	21	molecules	molecule	NOUN
admet-376	206	22	.	.	PUNCT
admet-376	207	1	inspection	inspection	NOUN
admet-376	207	2	of	of	ADP
admet-376	207	3	these	these	PRON
admet-376	207	4	indicated	indicate	VERB
admet-376	207	5	that	that	SCONJ
admet-376	207	6	they	they	PRON
admet-376	207	7	were	be	AUX
admet-376	207	8	mainly	mainly	ADV
admet-376	207	9	nutrients	nutrient	NOUN
admet-376	207	10	and	and	CCONJ
admet-376	207	11	their	their	PRON
admet-376	207	12	metabolites	metabolite	NOUN
admet-376	207	13	,	,	PUNCT
admet-376	207	14	along	along	ADP
admet-376	207	15	with	with	ADP
admet-376	207	16	the	the	DET
admet-376	207	17	metabolites	metabolite	NOUN
admet-376	207	18	of	of	ADP
admet-376	207	19	various	various	ADJ
admet-376	207	20	medicines	medicine	NOUN
admet-376	207	21	.	.	PUNCT
admet-376	208	1	of	of	ADP
admet-376	208	2	course	course	NOUN
admet-376	208	3	what	what	PRON
admet-376	208	4	is	be	AUX
admet-376	208	5	in	in	ADP
admet-376	208	6	serum	serum	NOUN
admet-376	208	7	largely	largely	ADV
admet-376	208	8	reflects	reflect	VERB
admet-376	208	9	what	what	PRON
admet-376	208	10	was	be	AUX
admet-376	208	11	recently	recently	ADV
admet-376	208	12	ingested	ingest	VERB
admet-376	208	13	,	,	PUNCT
admet-376	208	14	and	and	CCONJ
admet-376	208	15	so	so	ADV
admet-376	208	16	it	it	PRON
admet-376	208	17	can	can	AUX
admet-376	208	18	hardly	hardly	ADV
admet-376	208	19	be	be	AUX
admet-376	208	20	expected	expect	VERB
admet-376	208	21	to	to	PART
admet-376	208	22	include	include	VERB
admet-376	208	23	all	all	DET
admet-376	208	24	the	the	DET
admet-376	208	25	natural	natural	ADJ
admet-376	208	26	products	product	NOUN
admet-376	208	27	listed	list	VERB
admet-376	208	28	in	in	ADP
admet-376	208	29	unpd	unpd	NOUN
admet-376	208	30	and	and	CCONJ
admet-376	208	31	dnp	dnp	PROPN
admet-376	208	32	.	.	PUNCT
admet-376	209	1	the	the	DET
admet-376	209	2	curves	curve	NOUN
admet-376	209	3	are	be	AUX
admet-376	209	4	shown	show	VERB
admet-376	209	5	for	for	ADP
admet-376	209	6	both	both	CCONJ
admet-376	209	7	the	the	DET
admet-376	209	8	subset	subset	NOUN
admet-376	209	9	normalized	normalize	VERB
admet-376	209	10	to	to	ADP
admet-376	209	11	the	the	DET
admet-376	209	12	size	size	NOUN
admet-376	209	13	of	of	ADP
admet-376	209	14	recon	recon	NOUN
admet-376	209	15	2	2	NUM
admet-376	209	16	(	(	PUNCT
admet-376	209	17	figure	figure	NOUN
admet-376	209	18	10a	10a	NUM
admet-376	209	19	)	)	PUNCT
admet-376	209	20	and	and	CCONJ
admet-376	209	21	the	the	DET
admet-376	209	22	full	full	ADJ
admet-376	209	23	set	set	NOUN
admet-376	209	24	(	(	PUNCT
admet-376	209	25	figure	figure	NOUN
admet-376	209	26	1b	1b	NUM
admet-376	209	27	)	)	PUNCT
admet-376	209	28	.	.	PUNCT
admet-376	210	1	clearly	clearly	ADV
admet-376	210	2	,	,	PUNCT
admet-376	210	3	again	again	ADV
admet-376	210	4	,	,	PUNCT
admet-376	210	5	there	there	PRON
admet-376	210	6	are	be	VERB
admet-376	210	7	a	a	DET
admet-376	210	8	significant	significant	ADJ
admet-376	210	9	number	number	NOUN
admet-376	210	10	of	of	ADP
admet-376	210	11	‘	'	PUNCT
admet-376	210	12	serum	serum	NOUN
admet-376	210	13	’	'	PUNCT
admet-376	210	14	molecules	molecule	NOUN
admet-376	210	15	that	that	PRON
admet-376	210	16	are	be	AUX
admet-376	210	17	not	not	PART
admet-376	210	18	in	in	ADP
admet-376	210	19	recon2	recon2	NOUN
admet-376	210	20	yet	yet	ADV
admet-376	210	21	are	be	AUX
admet-376	210	22	structurally	structurally	ADV
admet-376	210	23	closer	close	ADJ
admet-376	210	24	to	to	ADP
admet-376	210	25	drugs	drug	NOUN
admet-376	210	26	.	.	PUNCT
admet-376	211	1	a	a	DET
admet-376	211	2	detailed	detailed	ADJ
admet-376	211	3	analysis	analysis	NOUN
admet-376	211	4	beyond	beyond	ADP
admet-376	211	5	this	this	PRON
admet-376	211	6	is	be	AUX
admet-376	211	7	not	not	PART
admet-376	211	8	particularly	particularly	ADV
admet-376	211	9	pointful	pointful	ADJ
admet-376	211	10	,	,	PUNCT
admet-376	211	11	since	since	SCONJ
admet-376	211	12	clearly	clearly	ADV
admet-376	211	13	what	what	PRON
admet-376	211	14	is	be	AUX
admet-376	211	15	in	in	ADP
admet-376	211	16	serum	serum	NOUN
admet-376	211	17	reflects	reflect	VERB
admet-376	211	18	recent	recent	ADJ
admet-376	211	19	ingestion	ingestion	NOUN
admet-376	211	20	only	only	ADV
admet-376	211	21	,	,	PUNCT
admet-376	211	22	and	and	CCONJ
admet-376	211	23	this	this	PRON
admet-376	211	24	is	be	AUX
admet-376	211	25	only	only	ADV
admet-376	211	26	a	a	DET
admet-376	211	27	small	small	ADJ
admet-376	211	28	subset	subset	NOUN
admet-376	211	29	of	of	ADP
admet-376	211	30	the	the	DET
admet-376	211	31	contents	content	NOUN
admet-376	211	32	of	of	ADP
admet-376	211	33	unpd	unpd	NOUN
admet-376	211	34	and	and	CCONJ
admet-376	211	35	dnp	dnp	PROPN
admet-376	211	36	(	(	PUNCT
admet-376	211	37	figure	figure	NOUN
admet-376	211	38	10c	10c	NOUN
admet-376	211	39	)	)	PUNCT
admet-376	211	40	.	.	PUNCT
admet-376	212	1	the	the	DET
admet-376	212	2	union	union	NOUN
admet-376	212	3	of	of	ADP
admet-376	212	4	the	the	DET
admet-376	212	5	unpd	unpd	NOUN
admet-376	212	6	and	and	CCONJ
admet-376	212	7	dnp	dnp	PROPN
admet-376	212	8	databases	database	NOUN
admet-376	212	9	since	since	SCONJ
admet-376	212	10	there	there	PRON
admet-376	212	11	was	be	VERB
admet-376	212	12	(	(	PUNCT
admet-376	212	13	surprisingly	surprisingly	ADV
admet-376	212	14	)	)	PUNCT
admet-376	212	15	little	little	ADJ
admet-376	212	16	overlap	overlap	NOUN
admet-376	212	17	in	in	ADP
admet-376	212	18	the	the	DET
admet-376	212	19	contents	content	NOUN
admet-376	212	20	of	of	ADP
admet-376	212	21	the	the	DET
admet-376	212	22	‘	'	PUNCT
admet-376	212	23	cleaned	clean	VERB
admet-376	212	24	’	'	PUNCT
admet-376	212	25	versions	version	NOUN
admet-376	212	26	of	of	ADP
admet-376	212	27	unpd	unpd	NOUN
admet-376	212	28	and	and	CCONJ
admet-376	212	29	dnp	dnp	PROPN
admet-376	212	30	(	(	PUNCT
admet-376	212	31	figures	figure	NOUN
admet-376	212	32	8	8	NUM
admet-376	212	33	,	,	PUNCT
admet-376	212	34	10c	10c	NOUN
admet-376	212	35	)	)	PUNCT
admet-376	212	36	,	,	PUNCT
admet-376	212	37	it	it	PRON
admet-376	212	38	was	be	AUX
admet-376	212	39	of	of	ADP
admet-376	212	40	especial	especial	ADJ
admet-376	212	41	interest	interest	NOUN
admet-376	212	42	to	to	PART
admet-376	212	43	run	run	VERB
admet-376	212	44	the	the	DET
admet-376	212	45	analysis	analysis	NOUN
admet-376	212	46	on	on	ADP
admet-376	212	47	their	their	PRON
admet-376	212	48	union	union	NOUN
admet-376	212	49	,	,	PUNCT
admet-376	212	50	a	a	DET
admet-376	212	51	set	set	NOUN
admet-376	212	52	of	of	ADP
admet-376	212	53	some	some	DET
admet-376	212	54	195,285	195,285	NUM
admet-376	212	55	molecules	molecule	NOUN
admet-376	212	56	.	.	PUNCT
admet-376	213	1	the	the	DET
admet-376	213	2	results	result	NOUN
admet-376	213	3	are	be	AUX
admet-376	213	4	shown	show	VERB
admet-376	213	5	in	in	ADP
admet-376	213	6	figure	figure	NOUN
admet-376	213	7	11a	11a	NOUN
admet-376	213	8	for	for	ADP
admet-376	213	9	the	the	DET
admet-376	213	10	full	full	ADJ
admet-376	213	11	set	set	NOUN
admet-376	213	12	for	for	ADP
admet-376	213	13	the	the	DET
admet-376	213	14	maccs	maccs	PROPN
admet-376	213	15	rank	rank	NOUN
admet-376	213	16	order	order	NOUN
admet-376	213	17	and	and	CCONJ
admet-376	213	18	tanimoto	tanimoto	NOUN
admet-376	213	19	similarities	similarity	NOUN
admet-376	213	20	,	,	PUNCT
admet-376	213	21	and	and	CCONJ
admet-376	213	22	for	for	ADP
admet-376	213	23	each	each	PRON
admet-376	213	24	of	of	ADP
admet-376	213	25	the	the	DET
admet-376	213	26	standard	standard	ADJ
admet-376	213	27	rdkit	rdkit	ADJ
admet-376	213	28	encodings	encoding	NOUN
admet-376	213	29	in	in	ADP
admet-376	213	30	figure	figure	NOUN
admet-376	213	31	11b	11b	NOUN
admet-376	213	32	for	for	ADP
admet-376	213	33	a	a	DET
admet-376	213	34	148k	148k	NUM
admet-376	213	35	subset	subset	NOUN
admet-376	213	36	.	.	PUNCT
admet-376	214	1	the	the	DET
admet-376	214	2	results	result	NOUN
admet-376	214	3	(	(	PUNCT
admet-376	214	4	figure	figure	NOUN
admet-376	214	5	11a	11a	NOUN
admet-376	214	6	,	,	PUNCT
admet-376	214	7	b	b	X
admet-376	214	8	)	)	PUNCT
admet-376	214	9	are	be	AUX
admet-376	214	10	absolutely	absolutely	ADV
admet-376	214	11	striking	striking	ADJ
admet-376	214	12	:	:	PUNCT
admet-376	214	13	for	for	ADP
admet-376	214	14	the	the	DET
admet-376	214	15	maccs	maccs	PROPN
admet-376	214	16	encoding	encoding	PROPN
admet-376	214	17	,	,	PUNCT
admet-376	214	18	45	45	NUM
admet-376	214	19	%	%	NOUN
admet-376	214	20	,	,	PUNCT
admet-376	214	21	60	60	NUM
admet-376	214	22	%	%	NOUN
admet-376	214	23	and	and	CCONJ
admet-376	214	24	80	80	NUM
admet-376	214	25	%	%	NOUN
admet-376	214	26	of	of	ADP
admet-376	214	27	marketed	market	VERB
admet-376	214	28	drugs	drug	NOUN
admet-376	214	29	are	be	AUX
admet-376	214	30	within	within	ADP
admet-376	214	31	a	a	DET
admet-376	214	32	ts	ts	NOUN
admet-376	214	33	of	of	ADP
admet-376	214	34	0.8	0.8	NUM
admet-376	214	35	,	,	PUNCT
admet-376	214	36	0.75	0.75	NUM
admet-376	214	37	and	and	CCONJ
admet-376	214	38	0.7	0.7	NUM
admet-376	214	39	to	to	PART
admet-376	214	40	at	at	ADV
admet-376	214	41	least	least	ADV
admet-376	214	42	one	one	NUM
admet-376	214	43	inhabitant	inhabitant	NOUN
admet-376	214	44	of	of	ADP
admet-376	214	45	the	the	DET
admet-376	214	46	union	union	NOUN
admet-376	214	47	of	of	ADP
admet-376	214	48	the	the	DET
admet-376	214	49	unpd	unpd	NOUN
admet-376	214	50	and	and	CCONJ
admet-376	214	51	dnp	dnp	PROPN
admet-376	214	52	databases	database	NOUN
admet-376	214	53	,	,	PUNCT
admet-376	214	54	regardless	regardless	ADV
admet-376	214	55	of	of	ADP
admet-376	214	56	the	the	DET
admet-376	214	57	inclusion	inclusion	NOUN
admet-376	214	58	of	of	ADP
admet-376	214	59	recon2	recon2	NOUN
admet-376	214	60	metabolites	metabolite	NOUN
admet-376	214	61	.	.	PUNCT
admet-376	215	1	figure	figure	NOUN
admet-376	215	2	11c	11c	NOUN
admet-376	215	3	shows	show	VERB
admet-376	215	4	the	the	DET
admet-376	215	5	data	datum	NOUN
admet-376	215	6	for	for	ADP
admet-376	215	7	the	the	DET
admet-376	215	8	multiple	multiple	ADJ
admet-376	215	9	encodings	encoding	NOUN
admet-376	215	10	.	.	PUNCT
admet-376	216	1	on	on	ADP
admet-376	216	2	this	this	DET
admet-376	216	3	basis	basis	NOUN
admet-376	216	4	,	,	PUNCT
admet-376	216	5	80	80	NUM
admet-376	216	6	%	%	NOUN
admet-376	216	7	of	of	ADP
admet-376	216	8	all	all	DET
admet-376	216	9	drugs	drug	NOUN
admet-376	216	10	are	be	AUX
admet-376	216	11	within	within	ADP
admet-376	216	12	a	a	DET
admet-376	216	13	ts	ts	NOUN
admet-376	216	14	of	of	ADP
admet-376	216	15	0.8	0.8	NUM
admet-376	216	16	of	of	ADP
admet-376	216	17	a	a	DET
admet-376	216	18	natural	natural	ADJ
admet-376	216	19	product	product	NOUN
admet-376	216	20	for	for	ADP
admet-376	216	21	the	the	DET
admet-376	216	22	patterned	pattern	VERB
admet-376	216	23	encoding	encoding	NOUN
admet-376	216	24	,	,	PUNCT
admet-376	216	25	and	and	CCONJ
admet-376	216	26	http://www.serummetabolome.ca/	http://www.serummetabolome.ca/	NUM
admet-376	216	27	admet	admet	PROPN
admet-376	216	28	&	&	CCONJ
admet-376	216	29	dmpk	dmpk	PROPN
admet-376	216	30	5(2	5(2	NUM
admet-376	216	31	)	)	PUNCT
admet-376	216	32	(	(	PUNCT
admet-376	216	33	2017	2017	NUM
admet-376	216	34	)	)	PUNCT
admet-376	216	35	85	85	NUM
admet-376	216	36	-	-	SYM
admet-376	216	37	125	125	NUM
admet-376	216	38	exogenous	exogenous	ADJ
admet-376	216	39	natural	natural	ADJ
admet-376	216	40	products	product	NOUN
admet-376	216	41	as	as	ADP
admet-376	216	42	‘	'	PUNCT
admet-376	216	43	natural	natural	ADJ
admet-376	216	44	’	'	PUNCT
admet-376	216	45	drug	drug	NOUN
admet-376	216	46	transporter	transporter	NOUN
admet-376	216	47	substrates	substrate	VERB
admet-376	216	48	doi	doi	NOUN
admet-376	216	49	:	:	PUNCT
admet-376	216	50	10.5599	10.5599	NUM
admet-376	216	51	/	/	SYM
admet-376	216	52	admet.5.2.376	admet.5.2.376	PROPN
admet-376	216	53	107	107	NUM
admet-376	216	54	almost	almost	ADV
admet-376	216	55	all	all	DET
admet-376	216	56	the	the	DET
admet-376	216	57	‘	'	PUNCT
admet-376	216	58	missing	missing	ADJ
admet-376	216	59	’	'	PUNCT
admet-376	216	60	molecules	molecule	NOUN
admet-376	216	61	with	with	ADP
admet-376	216	62	similarities	similarity	NOUN
admet-376	216	63	above	above	ADV
admet-376	216	64	say	say	VERB
admet-376	216	65	0.75	0.75	NUM
admet-376	216	66	are	be	AUX
admet-376	216	67	natural	natural	ADJ
admet-376	216	68	products	product	NOUN
admet-376	216	69	.	.	PUNCT
admet-376	217	1	this	this	PRON
admet-376	217	2	becomes	become	VERB
admet-376	217	3	even	even	ADV
admet-376	217	4	clearer	clear	ADJ
admet-376	217	5	in	in	ADP
admet-376	217	6	figure	figure	NOUN
admet-376	217	7	11d	11d	NOUN
admet-376	217	8	,	,	PUNCT
admet-376	217	9	where	where	SCONJ
admet-376	217	10	we	we	PRON
admet-376	217	11	chose	choose	VERB
admet-376	217	12	the	the	DET
admet-376	217	13	typical	typical	ADJ
admet-376	217	14	encoding	encoding	NOUN
admet-376	217	15	,	,	PUNCT
admet-376	217	16	i.e.	i.e.	X
admet-376	217	17	that	that	PRON
admet-376	217	18	which	which	PRON
admet-376	217	19	maximises	maximise	VERB
admet-376	217	20	the	the	DET
admet-376	217	21	ts	ts	NOUN
admet-376	217	22	between	between	ADP
admet-376	217	23	a	a	DET
admet-376	217	24	drug	drug	NOUN
admet-376	217	25	and	and	CCONJ
admet-376	217	26	a	a	DET
admet-376	217	27	comparator	comparator	NOUN
admet-376	217	28	molecule	molecule	NOUN
admet-376	217	29	,	,	PUNCT
admet-376	217	30	regardless	regardless	ADV
admet-376	217	31	of	of	ADP
admet-376	217	32	the	the	DET
admet-376	217	33	encoding	encoding	NOUN
admet-376	217	34	,	,	PUNCT
admet-376	217	35	and	and	CCONJ
admet-376	217	36	performed	perform	VERB
admet-376	217	37	this	this	PRON
admet-376	217	38	on	on	ADP
admet-376	217	39	the	the	DET
admet-376	217	40	full	full	ADJ
admet-376	217	41	combined	combined	ADJ
admet-376	217	42	natural	natural	ADJ
admet-376	217	43	proucts	prouct	NOUN
admet-376	217	44	dataset	dataset	NOUN
admet-376	217	45	of	of	ADP
admet-376	217	46	~196,000	~196,000	PUNCT
admet-376	217	47	molecules	molecule	NOUN
admet-376	217	48	.	.	PUNCT
admet-376	218	1	the	the	DET
admet-376	218	2	result	result	NOUN
admet-376	218	3	was	be	AUX
admet-376	218	4	that	that	SCONJ
admet-376	218	5	92	92	NUM
admet-376	218	6	%	%	NOUN
admet-376	218	7	,	,	PUNCT
admet-376	218	8	98	98	NUM
admet-376	218	9	%	%	NOUN
admet-376	218	10	and	and	CCONJ
admet-376	218	11	99.5	99.5	NUM
admet-376	218	12	%	%	NOUN
admet-376	218	13	are	be	AUX
admet-376	218	14	within	within	ADP
admet-376	218	15	a	a	DET
admet-376	218	16	ts	ts	NOUN
admet-376	218	17	of	of	ADP
admet-376	218	18	a	a	DET
admet-376	218	19	natural	natural	ADJ
admet-376	218	20	product	product	NOUN
admet-376	218	21	of	of	ADP
admet-376	218	22	0.9	0.9	NUM
admet-376	218	23	,	,	PUNCT
admet-376	218	24	0.85	0.85	NUM
admet-376	218	25	and	and	CCONJ
admet-376	218	26	0.8	0.8	NUM
admet-376	218	27	,	,	PUNCT
admet-376	218	28	respectively	respectively	ADV
admet-376	218	29	.	.	PUNCT
admet-376	219	1	figure	figure	NOUN
admet-376	219	2	11e	11e	NOUN
admet-376	219	3	shows	show	VERB
admet-376	219	4	the	the	DET
admet-376	219	5	rather	rather	ADV
admet-376	219	6	widespread	widespread	ADJ
admet-376	219	7	distribution	distribution	NOUN
admet-376	219	8	of	of	ADP
admet-376	219	9	‘	'	PUNCT
admet-376	219	10	winning	win	VERB
admet-376	219	11	’	'	PUNCT
admet-376	219	12	similarities	similarity	NOUN
admet-376	219	13	between	between	ADP
admet-376	219	14	the	the	DET
admet-376	219	15	different	different	ADJ
admet-376	219	16	encodings	encoding	NOUN
admet-376	219	17	.	.	PUNCT
admet-376	220	1	each	each	PRON
admet-376	220	2	is	be	AUX
admet-376	220	3	represented	represent	VERB
admet-376	220	4	at	at	ADP
admet-376	220	5	least	least	ADJ
admet-376	220	6	once	once	ADV
admet-376	220	7	,	,	PUNCT
admet-376	220	8	and	and	CCONJ
admet-376	220	9	,	,	PUNCT
admet-376	220	10	interestingly	interestingly	ADV
admet-376	220	11	(	(	PUNCT
admet-376	220	12	as	as	SCONJ
admet-376	220	13	is	be	AUX
admet-376	220	14	also	also	ADV
admet-376	220	15	clear	clear	ADJ
admet-376	220	16	from	from	ADP
admet-376	220	17	figure	figure	NOUN
admet-376	220	18	11c	11c	NOUN
admet-376	220	19	)	)	PUNCT
admet-376	220	20	,	,	PUNCT
admet-376	220	21	‘	'	PUNCT
admet-376	220	22	patterned	pattern	VERB
admet-376	220	23	’	'	PUNCT
admet-376	220	24	is	be	AUX
admet-376	220	25	the	the	DET
admet-376	220	26	most	most	ADV
admet-376	220	27	common	common	ADJ
admet-376	220	28	.	.	PUNCT
admet-376	221	1	this	this	PRON
admet-376	221	2	is	be	AUX
admet-376	221	3	a	a	DET
admet-376	221	4	more	more	ADV
admet-376	221	5	recent	recent	ADJ
admet-376	221	6	addition	addition	NOUN
admet-376	221	7	to	to	ADP
admet-376	221	8	the	the	DET
admet-376	221	9	rdkit	rdkit	ADJ
admet-376	221	10	stable	stable	ADJ
admet-376	221	11	,	,	PUNCT
admet-376	221	12	and	and	CCONJ
admet-376	221	13	was	be	AUX
admet-376	221	14	not	not	PART
admet-376	221	15	available	available	ADJ
admet-376	221	16	when	when	SCONJ
admet-376	221	17	the	the	DET
admet-376	221	18	comparison	comparison	NOUN
admet-376	221	19	in	in	ADP
admet-376	221	20	figure	figure	NOUN
admet-376	221	21	1	1	NUM
admet-376	221	22	was	be	AUX
admet-376	221	23	done	do	VERB
admet-376	221	24	[	[	PUNCT
admet-376	221	25	22	22	NUM
admet-376	221	26	]	]	PUNCT
admet-376	221	27	.	.	PUNCT
admet-376	222	1	however	however	ADV
admet-376	222	2	,	,	PUNCT
admet-376	222	3	the	the	DET
admet-376	222	4	next	next	ADJ
admet-376	222	5	most	most	ADV
admet-376	222	6	used	use	VERB
admet-376	222	7	are	be	AUX
admet-376	222	8	rdkit	rdkit	NOUN
admet-376	222	9	,	,	PUNCT
admet-376	222	10	maccs	maccs	PROPN
admet-376	222	11	,	,	PUNCT
admet-376	222	12	layered	layer	VERB
admet-376	222	13	,	,	PUNCT
admet-376	222	14	and	and	CCONJ
admet-376	222	15	morgan	morgan	PROPN
admet-376	222	16	;	;	PUNCT
admet-376	222	17	with	with	ADP
admet-376	222	18	the	the	DET
admet-376	222	19	exception	exception	NOUN
admet-376	222	20	of	of	ADP
admet-376	222	21	the	the	DET
admet-376	222	22	latter	latter	ADJ
admet-376	222	23	,	,	PUNCT
admet-376	222	24	the	the	DET
admet-376	222	25	same	same	ADJ
admet-376	222	26	may	may	AUX
admet-376	222	27	also	also	ADV
admet-376	222	28	be	be	AUX
admet-376	222	29	inferred	infer	VERB
admet-376	222	30	from	from	ADP
admet-376	222	31	the	the	DET
admet-376	222	32	endogenite	endogenite	NOUN
admet-376	222	33	-	-	PUNCT
admet-376	222	34	only	only	ADV
admet-376	222	35	data	datum	NOUN
admet-376	222	36	in	in	ADP
admet-376	222	37	figure	figure	NOUN
admet-376	222	38	1	1	NUM
admet-376	222	39	.	.	PUNCT
admet-376	223	1	there	there	PRON
admet-376	223	2	were	be	VERB
admet-376	223	3	exactly	exactly	ADV
admet-376	223	4	500	500	NUM
admet-376	223	5	occasions	occasion	NOUN
admet-376	223	6	on	on	ADP
admet-376	223	7	which	which	PRON
admet-376	223	8	at	at	ADP
admet-376	223	9	least	least	ADV
admet-376	223	10	one	one	NUM
admet-376	223	11	endogenite	endogenite	NOUN
admet-376	223	12	was	be	AUX
admet-376	223	13	the	the	DET
admet-376	223	14	closest	close	ADJ
admet-376	223	15	in	in	ADP
admet-376	223	16	at	at	ADV
admet-376	223	17	least	least	ADV
admet-376	223	18	one	one	NUM
admet-376	223	19	encoding	encoding	NOUN
admet-376	223	20	.	.	PUNCT
admet-376	224	1	however	however	ADV
admet-376	224	2	,	,	PUNCT
admet-376	224	3	when	when	SCONJ
admet-376	224	4	the	the	DET
admet-376	224	5	typical	typical	ADJ
admet-376	224	6	encoding	encoding	NOUN
admet-376	224	7	used	use	VERB
admet-376	224	8	,	,	PUNCT
admet-376	224	9	each	each	PRON
admet-376	224	10	of	of	ADP
admet-376	224	11	the	the	DET
admet-376	224	12	1381	1381	NUM
admet-376	224	13	drugs	drug	NOUN
admet-376	224	14	was	be	AUX
admet-376	224	15	closer	close	ADJ
admet-376	224	16	to	to	ADP
admet-376	224	17	(	(	PUNCT
admet-376	224	18	or	or	CCONJ
admet-376	224	19	equal	equal	ADJ
admet-376	224	20	with	with	ADP
admet-376	224	21	)	)	PUNCT
admet-376	224	22	at	at	ADP
admet-376	224	23	least	least	ADJ
admet-376	224	24	one	one	NUM
admet-376	224	25	exogenous	exogenous	ADJ
admet-376	224	26	natural	natural	ADJ
admet-376	224	27	product	product	NOUN
admet-376	224	28	that	that	PRON
admet-376	224	29	is	be	AUX
admet-376	224	30	in	in	ADP
admet-376	224	31	either	either	PRON
admet-376	224	32	or	or	CCONJ
admet-376	224	33	both	both	PRON
admet-376	224	34	of	of	ADP
admet-376	224	35	unpd	unpd	NOUN
admet-376	224	36	and	and	CCONJ
admet-376	224	37	dnp	dnp	PROPN
admet-376	224	38	than	than	SCONJ
admet-376	224	39	it	it	PRON
admet-376	224	40	is	be	AUX
admet-376	224	41	to	to	ADP
admet-376	224	42	an	an	DET
admet-376	224	43	endogenite	endogenite	NOUN
admet-376	224	44	(	(	PUNCT
admet-376	224	45	data	datum	NOUN
admet-376	224	46	not	not	PART
admet-376	224	47	shown	show	VERB
admet-376	224	48	)	)	PUNCT
admet-376	224	49	.	.	PUNCT
admet-376	225	1	finally	finally	ADV
admet-376	225	2	,	,	PUNCT
admet-376	225	3	in	in	ADP
admet-376	225	4	previous	previous	ADJ
admet-376	225	5	work	work	NOUN
admet-376	225	6	[	[	X
admet-376	225	7	15	15	NUM
admet-376	225	8	]	]	PUNCT
admet-376	225	9	,	,	PUNCT
admet-376	225	10	we	we	PRON
admet-376	225	11	had	have	AUX
admet-376	225	12	compared	compare	VERB
admet-376	225	13	a	a	DET
admet-376	225	14	meta	meta	ADJ
admet-376	225	15	-	-	PUNCT
admet-376	225	16	analysis	analysis	NOUN
admet-376	225	17	of	of	ADP
admet-376	225	18	680	680	NUM
admet-376	225	19	caco-2	caco-2	NUM
admet-376	225	20	cell	cell	NOUN
admet-376	225	21	permeabilities	permeability	NOUN
admet-376	225	22	of	of	ADP
admet-376	225	23	187	187	NUM
admet-376	225	24	marketed	market	VERB
admet-376	225	25	drugs	drug	NOUN
admet-376	225	26	with	with	ADP
admet-376	225	27	their	their	PRON
admet-376	225	28	endogenitelikeness	endogenitelikeness	ADJ
admet-376	225	29	(	(	PUNCT
admet-376	225	30	finding	find	VERB
admet-376	225	31	none	none	NOUN
admet-376	225	32	)	)	PUNCT
admet-376	225	33	.	.	PUNCT
admet-376	226	1	neither	neither	CCONJ
admet-376	226	2	did	do	AUX
admet-376	226	3	we	we	PRON
admet-376	226	4	find	find	VERB
admet-376	226	5	any	any	DET
admet-376	226	6	relationship	relationship	NOUN
admet-376	226	7	between	between	ADP
admet-376	226	8	caco-2	caco-2	NUM
admet-376	226	9	permeability	permeability	NOUN
admet-376	226	10	and	and	CCONJ
admet-376	226	11	any	any	DET
admet-376	226	12	analysis	analysis	NOUN
admet-376	226	13	of	of	ADP
admet-376	226	14	closeness	closeness	NOUN
admet-376	226	15	to	to	ADP
admet-376	226	16	the	the	DET
admet-376	226	17	union	union	NOUN
admet-376	226	18	of	of	ADP
admet-376	226	19	the	the	DET
admet-376	226	20	unpd	unpd	NOUN
admet-376	226	21	and	and	CCONJ
admet-376	226	22	dnp	dnp	PROPN
admet-376	226	23	databases	database	NOUN
admet-376	226	24	;	;	PUNCT
admet-376	226	25	as	as	ADP
admet-376	226	26	an	an	DET
admet-376	226	27	illustration	illustration	NOUN
admet-376	226	28	,	,	PUNCT
admet-376	226	29	figure	figure	NOUN
admet-376	226	30	11f	11f	NUM
admet-376	226	31	compares	compare	VERB
admet-376	226	32	the	the	DET
admet-376	226	33	same	same	ADJ
admet-376	226	34	permeabilities	permeability	NOUN
admet-376	226	35	with	with	ADP
admet-376	226	36	the	the	DET
admet-376	226	37	maximum	maximum	ADJ
admet-376	226	38	pattern	pattern	NOUN
admet-376	226	39	ts	ts	X
admet-376	226	40	.	.	PUNCT
admet-376	227	1	clearly	clearly	ADV
admet-376	227	2	any	any	DET
admet-376	227	3	causal	causal	ADJ
admet-376	227	4	relationship	relationship	NOUN
admet-376	227	5	that	that	PRON
admet-376	227	6	may	may	AUX
admet-376	227	7	exist	exist	VERB
admet-376	227	8	is	be	AUX
admet-376	227	9	overwhelmed	overwhelm	VERB
admet-376	227	10	by	by	ADP
admet-376	227	11	the	the	DET
admet-376	227	12	unknown	unknown	ADJ
admet-376	227	13	variance	variance	NOUN
admet-376	227	14	[	[	X
admet-376	227	15	14	14	NUM
admet-376	227	16	]	]	PUNCT
admet-376	227	17	in	in	ADP
admet-376	227	18	kcat	kcat	PROPN
admet-376	227	19	,	,	PUNCT
admet-376	227	20	promiscuity	promiscuity	NOUN
admet-376	227	21	,	,	PUNCT
admet-376	227	22	and	and	CCONJ
admet-376	227	23	transporter	transporter	NOUN
admet-376	227	24	expression	expression	NOUN
admet-376	227	25	levels	level	NOUN
admet-376	227	26	.	.	PUNCT
admet-376	228	1	figure	figure	NOUN
admet-376	228	2	10	10	NUM
admet-376	228	3	.	.	PUNCT
admet-376	229	1	human	human	ADJ
admet-376	229	2	serum	serum	PROPN
admet-376	229	3	metabolome	metabolome	PROPN
admet-376	229	4	.	.	PUNCT
admet-376	230	1	relationship	relationship	NOUN
admet-376	230	2	between	between	ADP
admet-376	230	3	the	the	DET
admet-376	230	4	normalised	normalise	VERB
admet-376	230	5	rank	rank	NOUN
admet-376	230	6	order	order	NOUN
admet-376	230	7	of	of	ADP
admet-376	230	8	the	the	DET
admet-376	230	9	nearest	near	ADJ
admet-376	230	10	molecule	molecule	NOUN
admet-376	230	11	to	to	AUX
admet-376	230	12	marketed	market	VERB
admet-376	230	13	drugs	drug	NOUN
admet-376	230	14	for	for	ADP
admet-376	230	15	the	the	DET
admet-376	230	16	‘	'	PUNCT
admet-376	230	17	human	human	ADJ
admet-376	230	18	serum	serum	NOUN
admet-376	230	19	metabolome	metabolome	NOUN
admet-376	230	20	’	'	PUNCT
admet-376	230	21	database	database	NOUN
admet-376	230	22	[	[	X
admet-376	230	23	122	122	NUM
admet-376	230	24	]	]	X
admet-376	230	25	(	(	PUNCT
admet-376	230	26	green	green	NOUN
admet-376	230	27	)	)	PUNCT
admet-376	230	28	and	and	CCONJ
admet-376	230	29	recon	recon	PROPN
admet-376	230	30	2	2	NUM
admet-376	230	31	(	(	PUNCT
admet-376	230	32	blue	blue	NOUN
admet-376	230	33	)	)	PUNCT
admet-376	230	34	.	.	PUNCT
admet-376	231	1	the	the	DET
admet-376	231	2	human	human	ADJ
admet-376	231	3	serum	serum	NOUN
admet-376	231	4	metabolome	metabolome	PROPN
admet-376	231	5	database	database	NOUN
admet-376	231	6	was	be	AUX
admet-376	231	7	‘	'	PUNCT
admet-376	231	8	cleaned	clean	VERB
admet-376	231	9	’	'	PUNCT
admet-376	231	10	to	to	PART
admet-376	231	11	remove	remove	VERB
admet-376	231	12	molecules	molecule	NOUN
admet-376	231	13	that	that	PRON
admet-376	231	14	were	be	AUX
admet-376	231	15	in	in	ADP
admet-376	231	16	either	either	DET
admet-376	231	17	recon2	recon2	NOUN
admet-376	231	18	or	or	CCONJ
admet-376	231	19	in	in	ADP
admet-376	231	20	the	the	DET
admet-376	231	21	list	list	NOUN
admet-376	231	22	of	of	ADP
admet-376	231	23	marketed	market	VERB
admet-376	231	24	drugs	drug	NOUN
admet-376	231	25	.	.	PUNCT
admet-376	232	1	a.	a.	NOUN
admet-376	232	2	sampled	sample	VERB
admet-376	232	3	subset	subset	VERB
admet-376	232	4	to	to	PART
admet-376	232	5	be	be	AUX
admet-376	232	6	the	the	DET
admet-376	232	7	same	same	ADJ
admet-376	232	8	size	size	NOUN
admet-376	232	9	and	and	CCONJ
admet-376	232	10	property	property	NOUN
admet-376	232	11	distribution	distribution	NOUN
admet-376	232	12	as	as	ADP
admet-376	232	13	that	that	PRON
admet-376	232	14	of	of	ADP
admet-376	232	15	recon2	recon2	NOUN
admet-376	232	16	.	.	PUNCT
admet-376	233	1	b.	b.	PROPN
admet-376	233	2	full	full	ADJ
admet-376	233	3	set	set	NOUN
admet-376	233	4	of	of	ADP
admet-376	233	5	‘	'	PUNCT
admet-376	233	6	human	human	ADJ
admet-376	233	7	serum	serum	NOUN
admet-376	233	8	metabolome	metabolome	NOUN
admet-376	233	9	’	'	PUNCT
admet-376	233	10	molecules	molecule	NOUN
admet-376	233	11	after	after	ADP
admet-376	233	12	cleaning	clean	VERB
admet-376	233	13	.	.	PUNCT
admet-376	234	1	c.	c.	PROPN
admet-376	234	2	venn	venn	PROPN
admet-376	234	3	diagram	diagram	PROPN
admet-376	234	4	of	of	ADP
admet-376	234	5	the	the	DET
admet-376	234	6	co	co	NOUN
admet-376	234	7	-	-	NOUN
admet-376	234	8	distributions	distribution	NOUN
admet-376	234	9	of	of	ADP
admet-376	234	10	molecules	molecule	NOUN
admet-376	234	11	in	in	ADP
admet-376	234	12	the	the	DET
admet-376	234	13	cleaned	clean	VERB
admet-376	234	14	versions	version	NOUN
admet-376	234	15	of	of	ADP
admet-376	234	16	unpd	unpd	NOUN
admet-376	234	17	,	,	PUNCT
admet-376	234	18	dnp	dnp	PROPN
admet-376	234	19	and	and	CCONJ
admet-376	234	20	the	the	DET
admet-376	234	21	human	human	ADJ
admet-376	234	22	serum	serum	NOUN
admet-376	234	23	metabolome	metabolome	NOUN
admet-376	234	24	databases	database	NOUN
admet-376	234	25	.	.	PUNCT
admet-376	235	1	o'hagan	o'hagan	PROPN
admet-376	235	2	&	&	CCONJ
admet-376	235	3	kell	kell	PROPN
admet-376	235	4	admet	admet	PROPN
admet-376	235	5	&	&	CCONJ
admet-376	235	6	dmpk	dmpk	PROPN
admet-376	235	7	5(2	5(2	NUM
admet-376	235	8	)	)	PUNCT
admet-376	235	9	(	(	PUNCT
admet-376	235	10	2017	2017	NUM
admet-376	235	11	)	)	PUNCT
admet-376	235	12	85	85	NUM
admet-376	235	13	-	-	SYM
admet-376	235	14	125	125	NUM
admet-376	235	15	108	108	NUM
admet-376	235	16	figure	figure	NOUN
admet-376	235	17	11	11	NUM
admet-376	235	18	.	.	PUNCT
admet-376	235	19	continued	continue	VERB
admet-376	235	20	on	on	ADP
admet-376	235	21	the	the	DET
admet-376	235	22	next	next	ADJ
admet-376	235	23	page	page	NOUN
admet-376	235	24	…	…	PUNCT
admet-376	235	25	admet	admet	PROPN
admet-376	235	26	&	&	CCONJ
admet-376	235	27	dmpk	dmpk	PROPN
admet-376	235	28	5(2	5(2	NUM
admet-376	235	29	)	)	PUNCT
admet-376	235	30	(	(	PUNCT
admet-376	235	31	2017	2017	NUM
admet-376	235	32	)	)	PUNCT
admet-376	235	33	85	85	NUM
admet-376	235	34	-	-	SYM
admet-376	235	35	125	125	NUM
admet-376	235	36	exogenous	exogenous	ADJ
admet-376	235	37	natural	natural	ADJ
admet-376	235	38	products	product	NOUN
admet-376	235	39	as	as	ADP
admet-376	235	40	‘	'	PUNCT
admet-376	235	41	natural	natural	ADJ
admet-376	235	42	’	'	PUNCT
admet-376	235	43	drug	drug	NOUN
admet-376	235	44	transporter	transporter	NOUN
admet-376	235	45	substrates	substrate	VERB
admet-376	235	46	doi	doi	NOUN
admet-376	235	47	:	:	PUNCT
admet-376	235	48	10.5599	10.5599	NUM
admet-376	235	49	/	/	SYM
admet-376	235	50	admet.5.2.376	admet.5.2.376	PROPN
admet-376	235	51	109	109	NUM
admet-376	235	52	figure	figure	NOUN
admet-376	235	53	11	11	NUM
admet-376	235	54	.	.	PUNCT
admet-376	236	1	…	…	PUNCT
admet-376	236	2	continued	continue	VERB
admet-376	236	3	on	on	ADP
admet-376	236	4	the	the	DET
admet-376	236	5	next	next	ADJ
admet-376	236	6	page	page	NOUN
admet-376	236	7	…	…	PUNCT
admet-376	236	8	o'hagan	o'hagan	PROPN
admet-376	236	9	&	&	CCONJ
admet-376	236	10	kell	kell	PROPN
admet-376	236	11	admet	admet	PROPN
admet-376	236	12	&	&	CCONJ
admet-376	236	13	dmpk	dmpk	PROPN
admet-376	236	14	5(2	5(2	NUM
admet-376	236	15	)	)	PUNCT
admet-376	236	16	(	(	PUNCT
admet-376	236	17	2017	2017	NUM
admet-376	236	18	)	)	PUNCT
admet-376	236	19	85	85	NUM
admet-376	236	20	-	-	SYM
admet-376	236	21	125	125	NUM
admet-376	236	22	110	110	NUM
admet-376	236	23	figure	figure	NOUN
admet-376	236	24	11	11	NUM
admet-376	236	25	.	.	PUNCT
admet-376	237	1	a.	a.	NOUN
admet-376	237	2	relationship	relationship	NOUN
admet-376	237	3	between	between	ADP
admet-376	237	4	the	the	DET
admet-376	237	5	normalised	normalise	VERB
admet-376	237	6	rank	rank	NOUN
admet-376	237	7	order	order	NOUN
admet-376	237	8	of	of	ADP
admet-376	237	9	the	the	DET
admet-376	237	10	nearest	near	ADJ
admet-376	237	11	molecule	molecule	NOUN
admet-376	237	12	to	to	AUX
admet-376	237	13	marketed	market	VERB
admet-376	237	14	drugs	drug	NOUN
admet-376	237	15	for	for	ADP
admet-376	237	16	the	the	DET
admet-376	237	17	union	union	NOUN
admet-376	237	18	of	of	ADP
admet-376	237	19	the	the	DET
admet-376	237	20	unpd	unpd	NOUN
admet-376	237	21	and	and	CCONJ
admet-376	237	22	dnp	dnp	PROPN
admet-376	237	23	natural	natural	ADJ
admet-376	237	24	products	product	NOUN
admet-376	237	25	databases	database	NOUN
admet-376	237	26	(	(	PUNCT
admet-376	237	27	green	green	ADJ
admet-376	237	28	)	)	PUNCT
admet-376	237	29	and	and	CCONJ
admet-376	237	30	recon	recon	PROPN
admet-376	237	31	2	2	NUM
admet-376	237	32	(	(	PUNCT
admet-376	237	33	blue	blue	NOUN
admet-376	237	34	)	)	PUNCT
admet-376	237	35	.	.	PUNCT
admet-376	238	1	the	the	DET
admet-376	238	2	unpd	unpd	NOUN
admet-376	238	3	and	and	CCONJ
admet-376	238	4	dnp	dnp	PROPN
admet-376	238	5	databases	database	NOUN
admet-376	238	6	were	be	AUX
admet-376	238	7	‘	'	PUNCT
admet-376	238	8	cleaned	clean	VERB
admet-376	238	9	’	'	PUNCT
admet-376	238	10	to	to	PART
admet-376	238	11	remove	remove	VERB
admet-376	238	12	molecules	molecule	NOUN
admet-376	238	13	that	that	PRON
admet-376	238	14	were	be	AUX
admet-376	238	15	in	in	ADP
admet-376	238	16	either	either	DET
admet-376	238	17	recon2	recon2	NOUN
admet-376	238	18	or	or	CCONJ
admet-376	238	19	in	in	ADP
admet-376	238	20	the	the	DET
admet-376	238	21	list	list	NOUN
admet-376	238	22	of	of	ADP
admet-376	238	23	marketed	market	VERB
admet-376	238	24	drugs	drug	NOUN
admet-376	238	25	.	.	PUNCT
admet-376	239	1	b.	b.	PROPN
admet-376	239	2	similar	similar	ADJ
admet-376	239	3	data	datum	NOUN
admet-376	239	4	plotted	plot	VERB
admet-376	239	5	for	for	ADP
admet-376	239	6	a	a	DET
admet-376	239	7	148k	148k	NUM
admet-376	239	8	normalised	normalise	VERB
admet-376	239	9	subset	subset	NOUN
admet-376	239	10	,	,	PUNCT
admet-376	239	11	also	also	ADV
admet-376	239	12	lacking	lack	VERB
admet-376	239	13	marketed	market	VERB
admet-376	239	14	drugs	drug	NOUN
admet-376	239	15	.	.	PUNCT
admet-376	240	1	c.	c.	NOUN
admet-376	240	2	the	the	DET
admet-376	240	3	same	same	ADJ
admet-376	240	4	,	,	PUNCT
admet-376	240	5	for	for	ADP
admet-376	240	6	each	each	PRON
admet-376	240	7	of	of	ADP
admet-376	240	8	the	the	DET
admet-376	240	9	standard	standard	ADJ
admet-376	240	10	rdkit	rdkit	ADJ
admet-376	240	11	encodings	encoding	NOUN
admet-376	240	12	.	.	PUNCT
admet-376	241	1	d.	d.	PROPN
admet-376	241	2	the	the	DET
admet-376	241	3	same	same	ADJ
admet-376	241	4	for	for	ADP
admet-376	241	5	the	the	DET
admet-376	241	6	typical	typical	ADJ
admet-376	241	7	encoding	encoding	NOUN
admet-376	241	8	.	.	PUNCT
admet-376	242	1	e.	e.	PROPN
admet-376	242	2	distribution	distribution	NOUN
admet-376	242	3	of	of	ADP
admet-376	242	4	encodings	encoding	NOUN
admet-376	242	5	used	use	VERB
admet-376	242	6	in	in	ADP
admet-376	242	7	the	the	DET
admet-376	242	8	winning	win	VERB
admet-376	242	9	molecules	molecule	NOUN
admet-376	242	10	that	that	PRON
admet-376	242	11	contributed	contribute	VERB
admet-376	242	12	to	to	ADP
admet-376	242	13	the	the	DET
admet-376	242	14	typical	typical	ADJ
admet-376	242	15	encoding	encoding	NOUN
admet-376	242	16	(	(	PUNCT
admet-376	242	17	the	the	DET
admet-376	242	18	encodings	encoding	NOUN
admet-376	242	19	are	be	AUX
admet-376	242	20	named	name	VERB
admet-376	242	21	according	accord	VERB
admet-376	242	22	to	to	ADP
admet-376	242	23	those	those	PRON
admet-376	242	24	provided	provide	VERB
admet-376	242	25	in	in	ADP
admet-376	242	26	rdkit	rdkit	NOUN
admet-376	242	27	as	as	ADP
admet-376	242	28	part	part	NOUN
admet-376	242	29	of	of	ADP
admet-376	242	30	the	the	DET
admet-376	242	31	knime	knime	PROPN
admet-376	242	32	environment	environment	NOUN
admet-376	242	33	)	)	PUNCT
admet-376	242	34	.	.	PUNCT
admet-376	243	1	f.	f.	PROPN
admet-376	243	2	lack	lack	NOUN
admet-376	243	3	of	of	ADP
admet-376	243	4	relationship	relationship	NOUN
admet-376	243	5	between	between	ADP
admet-376	243	6	caco-2	caco-2	NUM
admet-376	243	7	permeability	permeability	NOUN
admet-376	243	8	and	and	CCONJ
admet-376	243	9	maximum	maximum	NOUN
admet-376	243	10	ts	ts	ADP
admet-376	243	11	of	of	ADP
admet-376	243	12	the	the	DET
admet-376	243	13	union	union	NOUN
admet-376	243	14	of	of	ADP
admet-376	243	15	the	the	DET
admet-376	243	16	unpd	unpd	NOUN
admet-376	243	17	and	and	CCONJ
admet-376	243	18	dnp	dnp	PROPN
admet-376	243	19	databases	database	NOUN
admet-376	243	20	using	use	VERB
admet-376	243	21	the	the	DET
admet-376	243	22	pattern	pattern	NOUN
admet-376	243	23	encoding	encoding	NOUN
admet-376	243	24	(	(	PUNCT
admet-376	243	25	slope	slope	NOUN
admet-376	243	26	=	=	SYM
admet-376	243	27	-1.02	-1.02	NOUN
admet-376	243	28	,	,	PUNCT
admet-376	243	29	r	r	NOUN
admet-376	243	30	2	2	NUM
admet-376	243	31	=	=	SYM
admet-376	243	32	0.011	0.011	NUM
admet-376	243	33	.	.	PUNCT
admet-376	244	1	drugs	drug	NOUN
admet-376	244	2	are	be	AUX
admet-376	244	3	coloured	colour	VERB
admet-376	244	4	according	accord	VERB
admet-376	244	5	to	to	ADP
admet-376	244	6	the	the	DET
admet-376	244	7	encoding	encoding	NOUN
admet-376	244	8	with	with	ADP
admet-376	244	9	the	the	DET
admet-376	244	10	largest	large	ADJ
admet-376	244	11	ts	ts	NOUN
admet-376	244	12	.	.	PUNCT
admet-376	244	13	admet	admet	PROPN
admet-376	244	14	&	&	CCONJ
admet-376	244	15	dmpk	dmpk	PROPN
admet-376	244	16	5(2	5(2	NUM
admet-376	244	17	)	)	PUNCT
admet-376	244	18	(	(	PUNCT
admet-376	244	19	2017	2017	NUM
admet-376	244	20	)	)	PUNCT
admet-376	244	21	85	85	NUM
admet-376	244	22	-	-	SYM
admet-376	244	23	125	125	NUM
admet-376	244	24	exogenous	exogenous	ADJ
admet-376	244	25	natural	natural	ADJ
admet-376	244	26	products	product	NOUN
admet-376	244	27	as	as	ADP
admet-376	244	28	‘	'	PUNCT
admet-376	244	29	natural	natural	ADJ
admet-376	244	30	’	'	PUNCT
admet-376	244	31	drug	drug	NOUN
admet-376	244	32	transporter	transporter	NOUN
admet-376	244	33	substrates	substrate	VERB
admet-376	244	34	doi	doi	NOUN
admet-376	244	35	:	:	PUNCT
admet-376	244	36	10.5599	10.5599	NUM
admet-376	244	37	/	/	SYM
admet-376	244	38	admet.5.2.376	admet.5.2.376	PROPN
admet-376	244	39	111	111	NUM
admet-376	244	40	discussion	discussion	NOUN
admet-376	244	41	different	different	ADJ
admet-376	244	42	similarities	similarity	NOUN
admet-376	244	43	from	from	ADP
admet-376	244	44	different	different	ADJ
admet-376	244	45	encodings	encoding	NOUN
admet-376	244	46	as	as	SCONJ
admet-376	244	47	we	we	PRON
admet-376	244	48	continue	continue	VERB
admet-376	244	49	to	to	PART
admet-376	244	50	analyse	analyse	VERB
admet-376	244	51	the	the	DET
admet-376	244	52	structural	structural	ADJ
admet-376	244	53	‘	'	PUNCT
admet-376	244	54	similarities	similarity	NOUN
admet-376	244	55	’	'	PUNCT
admet-376	244	56	of	of	ADP
admet-376	244	57	drugs	drug	NOUN
admet-376	244	58	and	and	CCONJ
admet-376	244	59	endogenites	endogenite	NOUN
admet-376	244	60	in	in	ADP
admet-376	244	61	different	different	ADJ
admet-376	244	62	ways	way	NOUN
admet-376	244	63	[	[	X
admet-376	244	64	14	14	NUM
admet-376	244	65	,	,	PUNCT
admet-376	244	66	15	15	NUM
admet-376	244	67	,	,	PUNCT
admet-376	244	68	22	22	NUM
admet-376	244	69	-	-	SYM
admet-376	244	70	24	24	NUM
admet-376	244	71	,	,	PUNCT
admet-376	244	72	115	115	NUM
admet-376	244	73	]	]	PUNCT
admet-376	244	74	,	,	PUNCT
admet-376	244	75	it	it	PRON
admet-376	244	76	is	be	AUX
admet-376	244	77	becoming	become	VERB
admet-376	244	78	increasingly	increasingly	ADV
admet-376	244	79	clear	clear	ADJ
admet-376	244	80	that	that	SCONJ
admet-376	244	81	a	a	DET
admet-376	244	82	given	give	VERB
admet-376	244	83	drug	drug	NOUN
admet-376	244	84	-	-	PUNCT
admet-376	244	85	endogenite	endogenite	NOUN
admet-376	244	86	pair	pair	NOUN
admet-376	244	87	can	can	AUX
admet-376	244	88	have	have	VERB
admet-376	244	89	a	a	DET
admet-376	244	90	highly	highly	ADV
admet-376	244	91	variable	variable	ADJ
admet-376	244	92	numerical	numerical	ADJ
admet-376	244	93	similarity	similarity	NOUN
admet-376	244	94	depending	depend	VERB
admet-376	244	95	on	on	ADP
admet-376	244	96	which	which	PRON
admet-376	244	97	fingerprint	fingerprint	NOUN
admet-376	244	98	encoding	encoding	NOUN
admet-376	244	99	or	or	CCONJ
admet-376	244	100	metric	metric	NOUN
admet-376	244	101	of	of	ADP
admet-376	244	102	similarity	similarity	NOUN
admet-376	244	103	is	be	AUX
admet-376	244	104	used	use	VERB
admet-376	244	105	.	.	PUNCT
admet-376	245	1	in	in	ADP
admet-376	245	2	the	the	DET
admet-376	245	3	present	present	ADJ
admet-376	245	4	work	work	NOUN
admet-376	245	5	,	,	PUNCT
admet-376	245	6	we	we	PRON
admet-376	245	7	extend	extend	VERB
admet-376	245	8	this	this	DET
admet-376	245	9	recognition	recognition	NOUN
admet-376	245	10	to	to	ADP
admet-376	245	11	the	the	DET
admet-376	245	12	fact	fact	NOUN
admet-376	245	13	that	that	SCONJ
admet-376	245	14	–	–	PUNCT
admet-376	245	15	apart	apart	ADV
admet-376	245	16	from	from	ADP
admet-376	245	17	a	a	DET
admet-376	245	18	very	very	ADV
admet-376	245	19	small	small	ADJ
admet-376	245	20	subset	subset	NOUN
admet-376	245	21	of	of	ADP
admet-376	245	22	‘	'	PUNCT
admet-376	245	23	reliably	reliably	ADJ
admet-376	245	24	’	'	PUNCT
admet-376	245	25	endogenitesimilar	endogenitesimilar	ADJ
admet-376	245	26	drugs	drug	NOUN
admet-376	245	27	–	–	PUNCT
admet-376	245	28	the	the	DET
admet-376	245	29	degree	degree	NOUN
admet-376	245	30	of	of	ADP
admet-376	245	31	similarity	similarity	NOUN
admet-376	245	32	and	and	CCONJ
admet-376	245	33	its	its	PRON
admet-376	245	34	rank	rank	NOUN
admet-376	245	35	order	order	NOUN
admet-376	245	36	can	can	AUX
admet-376	245	37	be	be	AUX
admet-376	245	38	dominated	dominate	VERB
admet-376	245	39	by	by	ADP
admet-376	245	40	the	the	DET
admet-376	245	41	encoding	encoding	NOUN
admet-376	245	42	used	use	VERB
admet-376	245	43	.	.	PUNCT
admet-376	246	1	this	this	PRON
admet-376	246	2	was	be	AUX
admet-376	246	3	largely	largely	ADV
admet-376	246	4	not	not	PART
admet-376	246	5	the	the	DET
admet-376	246	6	case	case	NOUN
admet-376	246	7	in	in	ADP
admet-376	246	8	the	the	DET
admet-376	246	9	analysis	analysis	NOUN
admet-376	246	10	of	of	ADP
admet-376	246	11	riniker	riniker	NOUN
admet-376	246	12	and	and	CCONJ
admet-376	246	13	landrum	landrum	PROPN
admet-376	246	14	[	[	X
admet-376	246	15	113	113	NUM
admet-376	246	16	]	]	PUNCT
admet-376	246	17	,	,	PUNCT
admet-376	246	18	who	who	PRON
admet-376	246	19	compared	compare	VERB
admet-376	246	20	the	the	DET
admet-376	246	21	similarity	similarity	NOUN
admet-376	246	22	of	of	ADP
admet-376	246	23	fingerprints	fingerprint	NOUN
admet-376	246	24	of	of	ADP
admet-376	246	25	larger	large	ADJ
admet-376	246	26	and	and	CCONJ
admet-376	246	27	very	very	ADV
admet-376	246	28	different	different	ADJ
admet-376	246	29	datasets	dataset	NOUN
admet-376	246	30	of	of	ADP
admet-376	246	31	library	library	NOUN
admet-376	246	32	compounds	compound	NOUN
admet-376	246	33	.	.	PUNCT
admet-376	247	1	we	we	PRON
admet-376	247	2	also	also	ADV
admet-376	247	3	noted	note	VERB
admet-376	247	4	that	that	SCONJ
admet-376	247	5	we	we	PRON
admet-376	247	6	could	could	AUX
admet-376	247	7	predict	predict	VERB
admet-376	247	8	the	the	DET
admet-376	247	9	rank	rank	NOUN
admet-376	247	10	order	order	NOUN
admet-376	247	11	using	use	VERB
admet-376	247	12	random	random	ADJ
admet-376	247	13	forest	forest	NOUN
admet-376	247	14	regression	regression	NOUN
admet-376	247	15	,	,	PUNCT
admet-376	247	16	so	so	SCONJ
admet-376	247	17	it	it	PRON
admet-376	247	18	was	be	AUX
admet-376	247	19	,	,	PUNCT
admet-376	247	20	as	as	SCONJ
admet-376	247	21	expected	expect	VERB
admet-376	247	22	,	,	PUNCT
admet-376	247	23	a	a	DET
admet-376	247	24	deterministic	deterministic	ADJ
admet-376	247	25	property	property	NOUN
admet-376	247	26	.	.	PUNCT
admet-376	248	1	willett	willett	PROPN
admet-376	248	2	and	and	CCONJ
admet-376	248	3	colleagues	colleague	NOUN
admet-376	248	4	have	have	AUX
admet-376	248	5	suggested	suggest	VERB
admet-376	248	6	that	that	SCONJ
admet-376	248	7	‘	'	PUNCT
admet-376	248	8	fusing	fuse	VERB
admet-376	248	9	’	'	PUNCT
admet-376	248	10	the	the	DET
admet-376	248	11	results	result	NOUN
admet-376	248	12	of	of	ADP
admet-376	248	13	different	different	ADJ
admet-376	248	14	fingerprint	fingerprint	NOUN
admet-376	248	15	encodings	encoding	NOUN
admet-376	248	16	may	may	AUX
admet-376	248	17	give	give	VERB
admet-376	248	18	more	more	ADV
admet-376	248	19	robust	robust	ADJ
admet-376	248	20	analyses	analysis	NOUN
admet-376	248	21	[	[	X
admet-376	248	22	139	139	NUM
admet-376	248	23	-	-	SYM
admet-376	248	24	145	145	NUM
admet-376	248	25	]	]	PUNCT
admet-376	248	26	.	.	PUNCT
admet-376	249	1	our	our	PRON
admet-376	249	2	strategy	strategy	NOUN
admet-376	249	3	is	be	AUX
admet-376	249	4	somewhat	somewhat	ADV
admet-376	249	5	similar	similar	ADJ
admet-376	249	6	in	in	SCONJ
admet-376	249	7	that	that	SCONJ
admet-376	249	8	we	we	PRON
admet-376	249	9	recognise	recognise	VERB
admet-376	249	10	the	the	DET
admet-376	249	11	highly	highly	ADV
admet-376	249	12	variable	variable	ADJ
admet-376	249	13	rank	rank	NOUN
admet-376	249	14	orders	order	NOUN
admet-376	249	15	(	(	PUNCT
admet-376	249	16	and	and	CCONJ
admet-376	249	17	tanimoto	tanimoto	PROPN
admet-376	249	18	similarities	similarity	NOUN
admet-376	249	19	)	)	PUNCT
admet-376	249	20	that	that	PRON
admet-376	249	21	result	result	VERB
admet-376	249	22	from	from	ADP
admet-376	249	23	the	the	DET
admet-376	249	24	different	different	ADJ
admet-376	249	25	encodings	encoding	NOUN
admet-376	249	26	,	,	PUNCT
admet-376	249	27	such	such	ADJ
admet-376	249	28	that	that	SCONJ
admet-376	249	29	their	their	PRON
admet-376	249	30	variance	variance	NOUN
admet-376	249	31	tends	tend	VERB
admet-376	249	32	to	to	PART
admet-376	249	33	increase	increase	VERB
admet-376	249	34	with	with	ADP
admet-376	249	35	their	their	PRON
admet-376	249	36	mean	mean	ADJ
admet-376	249	37	rank	rank	NOUN
admet-376	249	38	order	order	NOUN
admet-376	249	39	.	.	PUNCT
admet-376	250	1	summing	sum	VERB
admet-376	250	2	(	(	PUNCT
admet-376	250	3	equivalently	equivalently	ADV
admet-376	250	4	,	,	PUNCT
admet-376	250	5	averaging	average	VERB
admet-376	250	6	)	)	PUNCT
admet-376	250	7	the	the	DET
admet-376	250	8	rank	rank	NOUN
admet-376	250	9	orders	order	NOUN
admet-376	250	10	(	(	PUNCT
admet-376	250	11	see	see	VERB
admet-376	250	12	also	also	ADV
admet-376	250	13	[	[	X
admet-376	250	14	139	139	NUM
admet-376	250	15	,	,	PUNCT
admet-376	250	16	145	145	NUM
admet-376	250	17	]	]	PUNCT
admet-376	250	18	)	)	PUNCT
admet-376	250	19	was	be	AUX
admet-376	250	20	a	a	DET
admet-376	250	21	particularly	particularly	ADV
admet-376	250	22	convenient	convenient	ADJ
admet-376	250	23	means	mean	NOUN
admet-376	250	24	of	of	ADP
admet-376	250	25	combining	combine	VERB
admet-376	250	26	the	the	DET
admet-376	250	27	data	datum	NOUN
admet-376	250	28	.	.	PUNCT
admet-376	251	1	when	when	SCONJ
admet-376	251	2	this	this	PRON
admet-376	251	3	was	be	AUX
admet-376	251	4	done	do	VERB
admet-376	251	5	,	,	PUNCT
admet-376	251	6	there	there	PRON
admet-376	251	7	was	be	VERB
admet-376	251	8	a	a	DET
admet-376	251	9	clear	clear	ADJ
admet-376	251	10	trend	trend	NOUN
admet-376	251	11	to	to	ADP
admet-376	251	12	the	the	DET
admet-376	251	13	effect	effect	NOUN
admet-376	251	14	that	that	SCONJ
admet-376	251	15	there	there	PRON
admet-376	251	16	was	be	VERB
admet-376	251	17	much	much	ADV
admet-376	251	18	less	less	ADJ
admet-376	251	19	variance	variance	NOUN
admet-376	251	20	among	among	ADP
admet-376	251	21	those	those	DET
admet-376	251	22	molecules	molecule	NOUN
admet-376	251	23	with	with	ADP
admet-376	251	24	the	the	DET
admet-376	251	25	most	most	ADV
admet-376	251	26	reliably	reliably	ADV
admet-376	251	27	high	high	ADJ
admet-376	251	28	rank	rank	NOUN
admet-376	251	29	order	order	NOUN
admet-376	251	30	(	(	PUNCT
admet-376	251	31	numerically	numerically	ADV
admet-376	251	32	small	small	ADJ
admet-376	251	33	values	value	NOUN
admet-376	251	34	)	)	PUNCT
admet-376	251	35	,	,	PUNCT
admet-376	251	36	leading	lead	VERB
admet-376	251	37	to	to	ADP
admet-376	251	38	a	a	DET
admet-376	251	39	conclusion	conclusion	NOUN
admet-376	251	40	that	that	SCONJ
admet-376	251	41	for	for	ADP
admet-376	251	42	tanimoto	tanimoto	PROPN
admet-376	251	43	similarity	similarity	NOUN
admet-376	251	44	values	value	NOUN
admet-376	251	45	over	over	ADP
admet-376	251	46	~0.75	~0.75	PROPN
admet-376	251	47	or	or	CCONJ
admet-376	251	48	0.8	0.8	NUM
admet-376	251	49	the	the	DET
admet-376	251	50	similarities	similarity	NOUN
admet-376	251	51	are	be	AUX
admet-376	251	52	fairly	fairly	ADV
admet-376	251	53	robust	robust	ADJ
admet-376	251	54	to	to	ADP
admet-376	251	55	the	the	DET
admet-376	251	56	specific	specific	ADJ
admet-376	251	57	encoding	encoding	NOUN
admet-376	251	58	used	use	VERB
admet-376	251	59	,	,	PUNCT
admet-376	251	60	and	and	CCONJ
admet-376	251	61	on	on	ADP
admet-376	251	62	that	that	DET
admet-376	251	63	basis	basis	NOUN
admet-376	251	64	may	may	AUX
admet-376	251	65	reasonably	reasonably	ADV
admet-376	251	66	be	be	AUX
admet-376	251	67	considered	consider	VERB
admet-376	251	68	‘	'	PUNCT
admet-376	251	69	reliable	reliable	ADJ
admet-376	251	70	’	'	PUNCT
admet-376	251	71	or	or	CCONJ
admet-376	251	72	‘	'	PUNCT
admet-376	251	73	significant	significant	ADJ
admet-376	251	74	’	'	PUNCT
admet-376	251	75	.	.	PUNCT
admet-376	252	1	this	this	PRON
admet-376	252	2	said	say	VERB
admet-376	252	3	,	,	PUNCT
admet-376	252	4	there	there	PRON
admet-376	252	5	was	be	VERB
admet-376	252	6	often	often	ADV
admet-376	252	7	at	at	ADP
admet-376	252	8	least	least	ADJ
admet-376	252	9	one	one	NUM
admet-376	252	10	encoding	encoding	NOUN
admet-376	252	11	for	for	ADP
admet-376	252	12	which	which	PRON
admet-376	252	13	the	the	DET
admet-376	252	14	ts	ts	NOUN
admet-376	252	15	between	between	ADP
admet-376	252	16	a	a	DET
admet-376	252	17	given	give	VERB
admet-376	252	18	drug	drug	NOUN
admet-376	252	19	and	and	CCONJ
admet-376	252	20	at	at	ADV
admet-376	252	21	least	least	ADV
admet-376	252	22	one	one	NUM
admet-376	252	23	endogenite	endogenite	NOUN
admet-376	252	24	exceeded	exceed	VERB
admet-376	252	25	0.75	0.75	NUM
admet-376	252	26	,	,	PUNCT
admet-376	252	27	such	such	ADJ
admet-376	252	28	that	that	SCONJ
admet-376	252	29	taking	take	VERB
admet-376	252	30	the	the	DET
admet-376	252	31	maximum	maximum	NOUN
admet-376	252	32	of	of	ADP
admet-376	252	33	these	these	PRON
admet-376	252	34	regardless	regardless	ADV
admet-376	252	35	of	of	ADP
admet-376	252	36	the	the	DET
admet-376	252	37	encoding	encoding	NOUN
admet-376	252	38	did	do	AUX
admet-376	252	39	increase	increase	VERB
admet-376	252	40	the	the	DET
admet-376	252	41	number	number	NOUN
admet-376	252	42	of	of	ADP
admet-376	252	43	‘	'	PUNCT
admet-376	252	44	similar	similar	ADJ
admet-376	252	45	’	'	PUNCT
admet-376	252	46	endogenites	endogenite	NOUN
admet-376	252	47	.	.	PUNCT
admet-376	253	1	unfortunately	unfortunately	ADV
admet-376	253	2	,	,	PUNCT
admet-376	253	3	with	with	ADP
admet-376	253	4	occasional	occasional	ADJ
admet-376	253	5	exceptions	exception	NOUN
admet-376	253	6	[	[	X
admet-376	253	7	146	146	NUM
admet-376	253	8	,	,	PUNCT
admet-376	253	9	147	147	NUM
admet-376	253	10	]	]	PUNCT
admet-376	253	11	,	,	PUNCT
admet-376	253	12	our	our	PRON
admet-376	253	13	knowledge	knowledge	NOUN
admet-376	253	14	of	of	ADP
admet-376	253	15	the	the	DET
admet-376	253	16	substrate	substrate	NOUN
admet-376	253	17	specificities	specificity	NOUN
admet-376	253	18	of	of	ADP
admet-376	253	19	individual	individual	ADJ
admet-376	253	20	transporters	transporter	NOUN
admet-376	253	21	is	be	AUX
admet-376	253	22	inadequate	inadequate	ADJ
admet-376	253	23	to	to	ADP
admet-376	253	24	the	the	DET
admet-376	253	25	task	task	NOUN
admet-376	253	26	of	of	ADP
admet-376	253	27	assessing	assess	VERB
admet-376	253	28	whether	whether	SCONJ
admet-376	253	29	the	the	DET
admet-376	253	30	‘	'	PUNCT
admet-376	253	31	nearest	near	ADJ
admet-376	253	32	’	'	PUNCT
admet-376	253	33	(	(	PUNCT
admet-376	253	34	or	or	CCONJ
admet-376	253	35	a	a	DET
admet-376	253	36	nearby	nearby	ADJ
admet-376	253	37	)	)	PUNCT
admet-376	253	38	metabolite	metabolite	NOUN
admet-376	253	39	is	be	AUX
admet-376	253	40	actually	actually	ADV
admet-376	253	41	the	the	DET
admet-376	253	42	‘	'	PUNCT
admet-376	253	43	natural	natural	ADJ
admet-376	253	44	’	'	PUNCT
admet-376	253	45	or	or	CCONJ
admet-376	253	46	endogenous	endogenous	ADJ
admet-376	253	47	substrate	substrate	NOUN
admet-376	254	1	[	[	X
admet-376	254	2	12	12	NUM
admet-376	254	3	]	]	PUNCT
admet-376	254	4	;	;	PUNCT
admet-376	254	5	by	by	ADP
admet-376	254	6	and	and	CCONJ
admet-376	254	7	large	large	ADJ
admet-376	254	8	,	,	PUNCT
admet-376	254	9	that	that	PRON
admet-376	254	10	will	will	AUX
admet-376	254	11	have	have	VERB
admet-376	254	12	to	to	PART
admet-376	254	13	await	await	VERB
admet-376	254	14	further	further	ADJ
admet-376	254	15	experimentation	experimentation	NOUN
admet-376	255	1	[	[	X
admet-376	255	2	12	12	NUM
admet-376	255	3	]	]	PUNCT
admet-376	255	4	.	.	PUNCT
admet-376	256	1	natural	natural	ADJ
admet-376	256	2	products	product	NOUN
admet-376	256	3	that	that	PRON
admet-376	256	4	are	be	AUX
admet-376	256	5	nutrients	nutrient	NOUN
admet-376	256	6	or	or	CCONJ
admet-376	256	7	bioactive	bioactive	ADJ
admet-376	256	8	drugs	drug	NOUN
admet-376	256	9	must	must	AUX
admet-376	256	10	necessarily	necessarily	ADV
admet-376	256	11	be	be	AUX
admet-376	256	12	transported	transport	VERB
admet-376	256	13	as	as	SCONJ
admet-376	256	14	was	be	AUX
admet-376	256	15	recognized	recognize	VERB
admet-376	256	16	from	from	ADP
admet-376	256	17	its	its	PRON
admet-376	256	18	inception	inception	NOUN
admet-376	257	1	[	[	X
admet-376	257	2	148	148	NUM
admet-376	257	3	]	]	PUNCT
admet-376	257	4	,	,	PUNCT
admet-376	257	5	the	the	DET
admet-376	257	6	‘	'	PUNCT
admet-376	257	7	rule	rule	NOUN
admet-376	257	8	of	of	ADP
admet-376	257	9	5	5	NUM
admet-376	257	10	’	'	PUNCT
admet-376	258	1	[	[	X
admet-376	258	2	148	148	NUM
admet-376	258	3	-	-	SYM
admet-376	258	4	154	154	NUM
admet-376	258	5	]	]	PUNCT
admet-376	258	6	is	be	AUX
admet-376	258	7	taken	take	VERB
admet-376	258	8	not	not	PART
admet-376	258	9	to	to	PART
admet-376	258	10	apply	apply	VERB
admet-376	258	11	to	to	ADP
admet-376	258	12	large	large	ADJ
admet-376	258	13	,	,	PUNCT
admet-376	258	14	natural	natural	ADJ
admet-376	258	15	products	product	NOUN
admet-376	258	16	,	,	PUNCT
admet-376	258	17	and	and	CCONJ
admet-376	258	18	also	also	ADV
admet-376	258	19	does	do	AUX
admet-376	258	20	not	not	PART
admet-376	258	21	apply	apply	VERB
admet-376	258	22	if	if	SCONJ
admet-376	258	23	transporters	transporter	NOUN
admet-376	258	24	are	be	AUX
admet-376	258	25	involved	involve	VERB
admet-376	258	26	in	in	ADP
admet-376	258	27	the	the	DET
admet-376	258	28	uptake	uptake	NOUN
admet-376	258	29	.	.	PUNCT
admet-376	259	1	natural	natural	ADJ
admet-376	259	2	products	product	NOUN
admet-376	259	3	have	have	AUX
admet-376	259	4	been	be	AUX
admet-376	259	5	and	and	CCONJ
admet-376	259	6	remain	remain	VERB
admet-376	259	7	a	a	DET
admet-376	259	8	major	major	ADJ
admet-376	259	9	source	source	NOUN
admet-376	259	10	of	of	ADP
admet-376	259	11	successful	successful	ADJ
admet-376	259	12	(	(	PUNCT
admet-376	259	13	marketed	market	VERB
admet-376	259	14	)	)	PUNCT
admet-376	259	15	pharmaceutical	pharmaceutical	ADJ
admet-376	259	16	drugs	drug	NOUN
admet-376	259	17	[	[	X
admet-376	259	18	155	155	NUM
admet-376	259	19	-	-	SYM
admet-376	259	20	162	162	NUM
admet-376	259	21	]	]	PUNCT
admet-376	259	22	,	,	PUNCT
admet-376	259	23	indeed	indeed	ADV
admet-376	259	24	,	,	PUNCT
admet-376	259	25	about	about	ADV
admet-376	259	26	one	one	NUM
admet-376	259	27	half	half	NOUN
admet-376	259	28	of	of	ADP
admet-376	259	29	new	new	ADJ
admet-376	259	30	drugs	drug	NOUN
admet-376	259	31	are	be	AUX
admet-376	259	32	based	base	VERB
admet-376	259	33	closely	closely	ADV
admet-376	259	34	on	on	ADP
admet-376	259	35	natural	natural	ADJ
admet-376	259	36	products	product	NOUN
admet-376	259	37	[	[	X
admet-376	259	38	157	157	NUM
admet-376	259	39	,	,	PUNCT
admet-376	259	40	158	158	NUM
admet-376	259	41	]	]	PUNCT
admet-376	259	42	,	,	PUNCT
admet-376	259	43	and	and	CCONJ
admet-376	259	44	many	many	ADJ
admet-376	259	45	transporters	transporter	NOUN
admet-376	259	46	exist	exist	VERB
admet-376	259	47	for	for	ADP
admet-376	259	48	them	they	PRON
admet-376	260	1	[	[	X
admet-376	260	2	163	163	NUM
admet-376	260	3	-	-	SYM
admet-376	260	4	166	166	NUM
admet-376	260	5	]	]	PUNCT
admet-376	260	6	.	.	PUNCT
admet-376	261	1	it	it	PRON
admet-376	261	2	is	be	AUX
admet-376	261	3	to	to	PART
admet-376	261	4	be	be	AUX
admet-376	261	5	assumed	assume	VERB
admet-376	261	6	that	that	SCONJ
admet-376	261	7	anything	anything	PRON
admet-376	261	8	that	that	PRON
admet-376	261	9	is	be	AUX
admet-376	261	10	of	of	ADP
admet-376	261	11	eventual	eventual	ADJ
admet-376	261	12	benefit	benefit	NOUN
admet-376	261	13	to	to	ADP
admet-376	261	14	(	(	PUNCT
admet-376	261	15	the	the	DET
admet-376	261	16	reproductive	reproductive	PROPN
admet-376	261	17	fitness	fitness	PROPN
admet-376	261	18	of	of	ADP
admet-376	261	19	)	)	PUNCT
admet-376	261	20	an	an	DET
admet-376	261	21	organism	organism	NOUN
admet-376	261	22	is	be	AUX
admet-376	261	23	likely	likely	ADJ
admet-376	261	24	to	to	PART
admet-376	261	25	be	be	AUX
admet-376	261	26	a	a	DET
admet-376	261	27	subject	subject	NOUN
admet-376	261	28	of	of	ADP
admet-376	261	29	natural	natural	ADJ
admet-376	261	30	selection	selection	NOUN
admet-376	261	31	and	and	CCONJ
admet-376	261	32	adaptive	adaptive	ADJ
admet-376	261	33	evolution	evolution	NOUN
admet-376	261	34	,	,	PUNCT
admet-376	261	35	even	even	ADV
admet-376	261	36	in	in	ADP
admet-376	261	37	the	the	DET
admet-376	261	38	laboratory	laboratory	NOUN
admet-376	262	1	[	[	X
admet-376	262	2	167	167	NUM
admet-376	262	3	]	]	PUNCT
admet-376	262	4	,	,	PUNCT
admet-376	262	5	in	in	ADP
admet-376	262	6	vitro	vitro	X
admet-376	262	7	[	[	X
admet-376	262	8	168	168	NUM
admet-376	262	9	]	]	PUNCT
admet-376	262	10	,	,	PUNCT
admet-376	262	11	and	and	CCONJ
admet-376	262	12	in	in	ADP
admet-376	262	13	silico	silico	NOUN
admet-376	262	14	[	[	X
admet-376	262	15	169	169	NUM
admet-376	262	16	]	]	PUNCT
admet-376	262	17	.	.	PUNCT
admet-376	263	1	thus	thus	ADV
admet-376	263	2	,	,	PUNCT
admet-376	263	3	if	if	SCONJ
admet-376	263	4	the	the	DET
admet-376	263	5	eating	eating	NOUN
admet-376	263	6	by	by	ADP
admet-376	263	7	a	a	DET
admet-376	263	8	mammal	mammal	NOUN
admet-376	263	9	of	of	ADP
admet-376	263	10	say	say	VERB
admet-376	263	11	a	a	DET
admet-376	263	12	plant	plant	NOUN
admet-376	263	13	or	or	CCONJ
admet-376	263	14	fungus	fungus	NOUN
admet-376	263	15	has	have	VERB
admet-376	263	16	beneficial	beneficial	ADJ
admet-376	263	17	properties	property	NOUN
admet-376	263	18	in	in	ADP
admet-376	263	19	terms	term	NOUN
admet-376	263	20	of	of	ADP
admet-376	263	21	improving	improve	VERB
admet-376	263	22	the	the	DET
admet-376	263	23	mammal	mammal	NOUN
admet-376	263	24	’s	’s	PART
admet-376	263	25	reproductive	reproductive	ADJ
admet-376	263	26	longevity	longevity	NOUN
admet-376	263	27	,	,	PUNCT
admet-376	263	28	selection	selection	NOUN
admet-376	263	29	will	will	AUX
admet-376	263	30	act	act	VERB
admet-376	263	31	to	to	PART
admet-376	263	32	enhance	enhance	VERB
admet-376	263	33	the	the	DET
admet-376	263	34	uptake	uptake	NOUN
admet-376	263	35	of	of	ADP
admet-376	263	36	the	the	DET
admet-376	263	37	bioactive	bioactive	ADJ
admet-376	263	38	principles	principle	NOUN
admet-376	263	39	,	,	PUNCT
admet-376	263	40	at	at	ADP
admet-376	263	41	least	least	ADJ
admet-376	263	42	to	to	ADP
admet-376	263	43	a	a	DET
admet-376	263	44	non	non	ADJ
admet-376	263	45	-	-	ADJ
admet-376	263	46	toxic	toxic	ADJ
admet-376	263	47	level	level	NOUN
admet-376	263	48	.	.	PUNCT
admet-376	264	1	certainly	certainly	ADV
admet-376	264	2	,	,	PUNCT
admet-376	264	3	as	as	SCONJ
admet-376	264	4	mentioned	mention	VERB
admet-376	264	5	,	,	PUNCT
admet-376	264	6	it	it	PRON
admet-376	264	7	is	be	AUX
admet-376	264	8	well	well	ADV
admet-376	264	9	established	establish	VERB
admet-376	264	10	that	that	DET
admet-376	264	11	natural	natural	ADJ
admet-376	264	12	products	product	NOUN
admet-376	264	13	themselves	themselves	PRON
admet-376	264	14	contribute	contribute	VERB
admet-376	264	15	importantly	importantly	ADV
admet-376	264	16	to	to	ADP
admet-376	264	17	the	the	DET
admet-376	264	18	development	development	NOUN
admet-376	264	19	of	of	ADP
admet-376	264	20	successful	successful	ADJ
admet-376	264	21	drugs	drug	NOUN
admet-376	264	22	(	(	PUNCT
admet-376	264	23	e.g.	e.g.	ADV
admet-376	264	24	[	[	X
admet-376	264	25	155	155	NUM
admet-376	264	26	-	-	SYM
admet-376	264	27	157	157	NUM
admet-376	264	28	,	,	PUNCT
admet-376	264	29	159162	159162	NUM
admet-376	264	30	,	,	PUNCT
admet-376	264	31	170	170	NUM
admet-376	264	32	-	-	SYM
admet-376	264	33	173	173	NUM
admet-376	264	34	]	]	PUNCT
admet-376	264	35	)	)	PUNCT
admet-376	264	36	.	.	PUNCT
admet-376	265	1	consequently	consequently	ADV
admet-376	265	2	it	it	PRON
admet-376	265	3	is	be	AUX
admet-376	265	4	clear	clear	ADJ
admet-376	265	5	that	that	SCONJ
admet-376	265	6	a	a	PRON
admet-376	265	7	or	or	CCONJ
admet-376	265	8	the	the	DET
admet-376	265	9	‘	'	PUNCT
admet-376	265	10	natural	natural	ADJ
admet-376	265	11	’	'	PUNCT
admet-376	265	12	substrate	substrate	NOUN
admet-376	265	13	of	of	ADP
admet-376	265	14	at	at	ADV
admet-376	265	15	least	least	ADJ
admet-376	265	16	some	some	PRON
admet-376	265	17	transporters	transporter	NOUN
admet-376	265	18	is	be	AUX
admet-376	265	19	in	in	ADP
admet-376	265	20	fact	fact	NOUN
admet-376	265	21	likely	likely	ADJ
admet-376	265	22	to	to	PART
admet-376	265	23	be	be	AUX
admet-376	265	24	an	an	DET
admet-376	265	25	exogenous	exogenous	ADJ
admet-376	265	26	molecule	molecule	NOUN
admet-376	265	27	that	that	PRON
admet-376	265	28	imparts	impart	VERB
admet-376	265	29	health	health	NOUN
admet-376	265	30	benefits	benefit	NOUN
admet-376	265	31	,	,	PUNCT
admet-376	265	32	and	and	CCONJ
admet-376	265	33	ergothioneine	ergothioneine	NOUN
admet-376	265	34	and	and	CCONJ
admet-376	265	35	its	its	PRON
admet-376	265	36	uptake	uptake	NOUN
admet-376	265	37	by	by	ADP
admet-376	265	38	slc22a4	slc22a4	PROPN
admet-376	265	39	seem	seem	VERB
admet-376	265	40	to	to	PART
admet-376	265	41	provide	provide	VERB
admet-376	265	42	a	a	DET
admet-376	265	43	very	very	ADV
admet-376	265	44	clear	clear	ADJ
admet-376	265	45	example	example	NOUN
admet-376	266	1	[	[	X
admet-376	266	2	49	49	NUM
admet-376	266	3	,	,	PUNCT
admet-376	266	4	50	50	NUM
admet-376	266	5	,	,	PUNCT
admet-376	266	6	59	59	NUM
admet-376	266	7	,	,	PUNCT
admet-376	266	8	65	65	NUM
admet-376	266	9	,	,	PUNCT
admet-376	266	10	66	66	NUM
admet-376	266	11	]	]	PUNCT
admet-376	266	12	.	.	PUNCT
admet-376	267	1	the	the	DET
admet-376	267	2	acquisition	acquisition	NOUN
admet-376	267	3	of	of	ADP
admet-376	267	4	the	the	DET
admet-376	267	5	ability	ability	NOUN
admet-376	267	6	to	to	PART
admet-376	267	7	maintain	maintain	VERB
admet-376	267	8	lactase	lactase	NOUN
admet-376	267	9	into	into	ADP
admet-376	267	10	adulthood	adulthood	NOUN
admet-376	267	11	(	(	PUNCT
admet-376	267	12	hence	hence	ADV
admet-376	267	13	to	to	PART
admet-376	267	14	tolerate	tolerate	VERB
admet-376	267	15	lactose	lactose	NOUN
admet-376	267	16	and	and	CCONJ
admet-376	267	17	dairy	dairy	NOUN
admet-376	267	18	products	product	NOUN
admet-376	267	19	)	)	PUNCT
admet-376	267	20	is	be	AUX
admet-376	267	21	highly	highly	ADV
admet-376	267	22	heterogeneous	heterogeneous	ADJ
admet-376	267	23	and	and	CCONJ
admet-376	267	24	of	of	ADP
admet-376	267	25	recent	recent	ADJ
admet-376	267	26	evolutionary	evolutionary	ADJ
admet-376	267	27	origin	origin	NOUN
admet-376	267	28	(	(	PUNCT
admet-376	267	29	~5000y	~5000y	PROPN
admet-376	267	30	bp	bp	PROPN
admet-376	267	31	[	[	X
admet-376	267	32	174	174	NUM
admet-376	267	33	-	-	SYM
admet-376	267	34	178	178	NUM
admet-376	267	35	]	]	PUNCT
admet-376	267	36	)	)	PUNCT
admet-376	267	37	.	.	PUNCT
admet-376	268	1	similarly	similarly	ADV
admet-376	268	2	,	,	PUNCT
admet-376	268	3	the	the	DET
admet-376	268	4	o'hagan	o'hagan	PROPN
admet-376	268	5	&	&	CCONJ
admet-376	268	6	kell	kell	PROPN
admet-376	268	7	admet	admet	PROPN
admet-376	268	8	&	&	CCONJ
admet-376	268	9	dmpk	dmpk	PROPN
admet-376	268	10	5(2	5(2	NUM
admet-376	268	11	)	)	PUNCT
admet-376	268	12	(	(	PUNCT
admet-376	268	13	2017	2017	NUM
admet-376	268	14	)	)	PUNCT
admet-376	268	15	85	85	NUM
admet-376	268	16	-	-	SYM
admet-376	268	17	125	125	NUM
admet-376	268	18	112	112	NUM
admet-376	268	19	actual	actual	ADJ
admet-376	268	20	human	human	ADJ
admet-376	268	21	selection	selection	NOUN
admet-376	268	22	and	and	CCONJ
admet-376	268	23	prescription	prescription	NOUN
admet-376	268	24	of	of	ADP
admet-376	268	25	plants	plant	NOUN
admet-376	268	26	as	as	ADP
admet-376	268	27	medications	medication	NOUN
admet-376	268	28	is	be	AUX
admet-376	268	29	of	of	ADP
admet-376	268	30	similar	similar	ADJ
admet-376	268	31	vintage	vintage	NOUN
admet-376	268	32	[	[	X
admet-376	268	33	89	89	NUM
admet-376	268	34	,	,	PUNCT
admet-376	268	35	91	91	NUM
admet-376	268	36	-	-	SYM
admet-376	268	37	93	93	NUM
admet-376	268	38	]	]	PUNCT
admet-376	268	39	,	,	PUNCT
admet-376	268	40	albeit	albeit	SCONJ
admet-376	268	41	hominids	hominid	NOUN
admet-376	268	42	and	and	CCONJ
admet-376	268	43	their	their	PRON
admet-376	268	44	evolutionary	evolutionary	ADJ
admet-376	268	45	predecessors	predecessor	NOUN
admet-376	268	46	have	have	AUX
admet-376	268	47	been	be	AUX
admet-376	268	48	eating	eat	VERB
admet-376	268	49	plants	plant	NOUN
admet-376	268	50	and	and	CCONJ
admet-376	268	51	fungi	fungus	NOUN
admet-376	268	52	for	for	ADP
admet-376	268	53	many	many	ADJ
admet-376	268	54	more	more	ADJ
admet-376	268	55	millennia	millennia	NOUN
admet-376	268	56	(	(	PUNCT
admet-376	268	57	angiosperms	angiosperm	NOUN
admet-376	268	58	appear	appear	VERB
admet-376	268	59	50	50	NUM
admet-376	268	60	-	-	PUNCT
admet-376	268	61	100my	100my	NOUN
admet-376	268	62	ago	ago	ADV
admet-376	268	63	)	)	PUNCT
admet-376	268	64	.	.	PUNCT
admet-376	269	1	hence	hence	ADV
admet-376	269	2	,	,	PUNCT
admet-376	269	3	while	while	SCONJ
admet-376	269	4	it	it	PRON
admet-376	269	5	is	be	AUX
admet-376	269	6	not	not	PART
admet-376	269	7	possible	possible	ADJ
admet-376	269	8	to	to	PART
admet-376	269	9	replay	replay	VERB
admet-376	269	10	the	the	DET
admet-376	269	11	evolutionary	evolutionary	ADJ
admet-376	269	12	tape	tape	NOUN
admet-376	269	13	,	,	PUNCT
admet-376	269	14	it	it	PRON
admet-376	269	15	is	be	AUX
admet-376	269	16	entirely	entirely	ADV
admet-376	269	17	reasonable	reasonable	ADJ
admet-376	269	18	that	that	SCONJ
admet-376	269	19	many	many	ADJ
admet-376	269	20	of	of	ADP
admet-376	269	21	the	the	DET
admet-376	269	22	several	several	ADJ
admet-376	269	23	hundred	hundred	NUM
admet-376	269	24	human	human	ADJ
admet-376	269	25	uptake	uptake	ADJ
admet-376	269	26	transporters	transporter	NOUN
admet-376	269	27	[	[	X
admet-376	269	28	69	69	NUM
admet-376	269	29	]	]	PUNCT
admet-376	269	30	were	be	AUX
admet-376	269	31	in	in	ADP
admet-376	269	32	fact	fact	NOUN
admet-376	269	33	selected	select	VERB
admet-376	269	34	,	,	PUNCT
admet-376	269	35	at	at	ADP
admet-376	269	36	least	least	ADJ
admet-376	269	37	in	in	ADP
admet-376	269	38	part	part	NOUN
admet-376	269	39	,	,	PUNCT
admet-376	269	40	precisely	precisely	ADV
admet-376	269	41	to	to	PART
admet-376	269	42	transport	transport	VERB
admet-376	269	43	exogenous	exogenous	ADJ
admet-376	269	44	secondary	secondary	ADJ
admet-376	269	45	metabolites	metabolite	NOUN
admet-376	269	46	.	.	PUNCT
admet-376	270	1	indeed	indeed	ADV
admet-376	270	2	,	,	PUNCT
admet-376	270	3	mammalian	mammalian	ADJ
admet-376	270	4	transporters	transporter	NOUN
admet-376	270	5	are	be	AUX
admet-376	270	6	well	well	ADV
admet-376	270	7	known	known	ADJ
admet-376	270	8	for	for	ADP
admet-376	270	9	their	their	PRON
admet-376	270	10	ability	ability	NOUN
admet-376	270	11	to	to	PART
admet-376	270	12	transport	transport	VERB
admet-376	270	13	many	many	ADJ
admet-376	270	14	exogenous	exogenous	ADJ
admet-376	270	15	natural	natural	ADJ
admet-376	270	16	product	product	NOUN
admet-376	270	17	drugs	drug	NOUN
admet-376	270	18	,	,	PUNCT
admet-376	270	19	e.g.	e.g.	ADV
admet-376	270	20	,	,	PUNCT
admet-376	270	21	slco	slco	ADV
admet-376	270	22	family	family	NOUN
admet-376	270	23	members	member	NOUN
admet-376	270	24	for	for	ADP
admet-376	270	25	penicillins	penicillin	NOUN
admet-376	270	26	[	[	X
admet-376	270	27	179	179	NUM
admet-376	270	28	,	,	PUNCT
admet-376	270	29	180	180	NUM
admet-376	270	30	]	]	PUNCT
admet-376	270	31	,	,	PUNCT
admet-376	270	32	cephalosporins	cephalosporin	VERB
admet-376	270	33	[	[	X
admet-376	270	34	181	181	NUM
admet-376	270	35	,	,	PUNCT
admet-376	270	36	182	182	NUM
admet-376	270	37	]	]	PUNCT
admet-376	270	38	,	,	PUNCT
admet-376	270	39	tetracycline	tetracycline	NOUN
admet-376	271	1	[	[	X
admet-376	271	2	183	183	NUM
admet-376	271	3	]	]	PUNCT
admet-376	271	4	,	,	PUNCT
admet-376	271	5	caffeine	caffeine	NOUN
admet-376	271	6	,	,	PUNCT
admet-376	271	7	theobromine	theobromine	NOUN
admet-376	271	8	and	and	CCONJ
admet-376	271	9	theophylline	theophylline	NOUN
admet-376	272	1	[	[	X
admet-376	272	2	184	184	NUM
admet-376	272	3	]	]	PUNCT
admet-376	272	4	and	and	CCONJ
admet-376	272	5	digoxin	digoxin	NOUN
admet-376	272	6	[	[	X
admet-376	272	7	185	185	NUM
admet-376	272	8	]	]	PUNCT
admet-376	272	9	,	,	PUNCT
admet-376	272	10	slc22	slc22	NOUN
admet-376	272	11	for	for	ADP
admet-376	272	12	berberine	berberine	NOUN
admet-376	272	13	[	[	X
admet-376	272	14	186	186	NUM
admet-376	272	15	]	]	PUNCT
admet-376	272	16	and	and	CCONJ
admet-376	272	17	protoberberines	protoberberine	NOUN
admet-376	273	1	[	[	X
admet-376	273	2	187	187	NUM
admet-376	273	3	]	]	PUNCT
admet-376	273	4	,	,	PUNCT
admet-376	273	5	morphine	morphine	NOUN
admet-376	274	1	[	[	X
admet-376	274	2	188	188	NUM
admet-376	274	3	]	]	PUNCT
admet-376	274	4	,	,	PUNCT
admet-376	274	5	erythromycin	erythromycin	VERB
admet-376	274	6	[	[	X
admet-376	274	7	189	189	NUM
admet-376	274	8	]	]	PUNCT
admet-376	274	9	and	and	CCONJ
admet-376	274	10	theophylline	theophylline	NOUN
admet-376	275	1	[	[	X
admet-376	275	2	189	189	NUM
admet-376	275	3	]	]	PUNCT
admet-376	275	4	,	,	PUNCT
admet-376	275	5	slc15	slc15	NOUN
admet-376	275	6	for	for	ADP
admet-376	275	7	penicillins	penicillin	NOUN
admet-376	275	8	and	and	CCONJ
admet-376	275	9	cephalosporins	cephalosporin	NOUN
admet-376	275	10	[	[	X
admet-376	275	11	190	190	NUM
admet-376	275	12	,	,	PUNCT
admet-376	275	13	191	191	NUM
admet-376	275	14	]	]	PUNCT
admet-376	275	15	,	,	PUNCT
admet-376	275	16	slc6	slc6	PROPN
admet-376	275	17	family	family	NOUN
admet-376	275	18	(	(	PUNCT
admet-376	275	19	norepinephrine	norepinephrine	NOUN
admet-376	275	20	transporters	transporter	NOUN
admet-376	275	21	)	)	PUNCT
admet-376	276	1	[	[	X
admet-376	276	2	192	192	NUM
admet-376	276	3	]	]	PUNCT
admet-376	276	4	for	for	ADP
admet-376	276	5	ephedrine	ephedrine	NOUN
admet-376	276	6	derivatives	derivative	NOUN
admet-376	276	7	[	[	X
admet-376	276	8	193	193	NUM
admet-376	276	9	]	]	PUNCT
admet-376	276	10	,	,	PUNCT
admet-376	276	11	and	and	CCONJ
admet-376	276	12	slc36	slc36	NOUN
admet-376	276	13	for	for	ADP
admet-376	276	14	arecaidine	arecaidine	NOUN
admet-376	276	15	(	(	PUNCT
admet-376	276	16	an	an	DET
admet-376	276	17	active	active	ADJ
admet-376	276	18	constituent	constituent	NOUN
admet-376	276	19	of	of	ADP
admet-376	276	20	the	the	DET
admet-376	276	21	areca	areca	PROPN
admet-376	276	22	nut	nut	NOUN
admet-376	276	23	,	,	PUNCT
admet-376	276	24	often	often	ADV
admet-376	276	25	wrongly	wrongly	ADV
admet-376	276	26	referred	refer	VERB
admet-376	276	27	to	to	ADP
admet-376	276	28	as	as	ADP
admet-376	276	29	the	the	DET
admet-376	276	30	betel	betel	NOUN
admet-376	276	31	nut	nut	NOUN
admet-376	276	32	)	)	PUNCT
admet-376	277	1	[	[	X
admet-376	277	2	194	194	NUM
admet-376	277	3	]	]	PUNCT
admet-376	277	4	.	.	PUNCT
admet-376	278	1	of	of	ADP
admet-376	278	2	necessity	necessity	NOUN
admet-376	278	3	,	,	PUNCT
admet-376	278	4	there	there	PRON
admet-376	278	5	are	be	VERB
admet-376	278	6	transporters	transporter	NOUN
admet-376	278	7	for	for	ADP
admet-376	278	8	exogenous	exogenous	ADJ
admet-376	278	9	natural	natural	ADJ
admet-376	278	10	products	product	NOUN
admet-376	278	11	that	that	PRON
admet-376	278	12	serve	serve	VERB
admet-376	278	13	as	as	ADP
admet-376	278	14	vitamins	vitamin	NOUN
admet-376	278	15	,	,	PUNCT
admet-376	278	16	such	such	ADJ
admet-376	278	17	as	as	ADP
admet-376	278	18	ascorbate	ascorbate	NOUN
admet-376	278	19	(	(	PUNCT
admet-376	278	20	slc23	slc23	ADJ
admet-376	278	21	family	family	NOUN
admet-376	278	22	[	[	X
admet-376	278	23	195	195	NUM
admet-376	278	24	,	,	PUNCT
admet-376	278	25	196	196	NUM
admet-376	278	26	]	]	PUNCT
admet-376	278	27	)	)	PUNCT
admet-376	278	28	,	,	PUNCT
admet-376	278	29	folate	folate	NOUN
admet-376	278	30	(	(	PUNCT
admet-376	278	31	slc19	slc19	NOUN
admet-376	278	32	and	and	CCONJ
admet-376	278	33	slc46	slc46	PROPN
admet-376	278	34	[	[	X
admet-376	278	35	197	197	NUM
admet-376	278	36	-	-	SYM
admet-376	278	37	199	199	NUM
admet-376	278	38	]	]	PUNCT
admet-376	278	39	)	)	PUNCT
admet-376	278	40	,	,	PUNCT
admet-376	278	41	biotin	biotin	NOUN
admet-376	278	42	and	and	CCONJ
admet-376	278	43	pantothenate	pantothenate	NOUN
admet-376	278	44	(	(	PUNCT
admet-376	278	45	slc5	slc5	PROPN
admet-376	279	1	[	[	X
admet-376	279	2	200	200	NUM
admet-376	279	3	]	]	NUM
admet-376	279	4	)	)	PUNCT
admet-376	279	5	,	,	PUNCT
admet-376	279	6	nicotinate	nicotinate	ADJ
admet-376	279	7	[	[	X
admet-376	279	8	201	201	NUM
admet-376	279	9	]	]	PUNCT
admet-376	279	10	,	,	PUNCT
admet-376	279	11	thiamine	thiamine	NOUN
admet-376	279	12	(	(	PUNCT
admet-376	279	13	slc19	slc19	NOUN
admet-376	279	14	and	and	CCONJ
admet-376	279	15	slco	slco	ADV
admet-376	280	1	[	[	X
admet-376	280	2	202	202	NUM
admet-376	280	3	-	-	SYM
admet-376	280	4	205	205	NUM
admet-376	280	5	]	]	PUNCT
admet-376	280	6	)	)	PUNCT
admet-376	280	7	,	,	PUNCT
admet-376	280	8	and	and	CCONJ
admet-376	280	9	riboflavin	riboflavin	NOUN
admet-376	280	10	(	(	PUNCT
admet-376	280	11	slc52	slc52	VERB
admet-376	280	12	[	[	PRON
admet-376	280	13	206	206	NUM
admet-376	280	14	-	-	SYM
admet-376	280	15	210	210	NUM
admet-376	280	16	]	]	PUNCT
admet-376	280	17	)	)	PUNCT
admet-376	280	18	.	.	PUNCT
admet-376	281	1	in	in	ADP
admet-376	281	2	other	other	ADJ
admet-376	281	3	cases	case	NOUN
admet-376	281	4	the	the	DET
admet-376	281	5	role	role	NOUN
admet-376	281	6	of	of	ADP
admet-376	281	7	human	human	ADJ
admet-376	281	8	protein	protein	NOUN
admet-376	281	9	transporters	transporter	NOUN
admet-376	281	10	of	of	ADP
admet-376	281	11	natural	natural	ADJ
admet-376	281	12	products	product	NOUN
admet-376	281	13	is	be	AUX
admet-376	281	14	well	well	ADV
admet-376	281	15	established	establish	VERB
admet-376	281	16	,	,	PUNCT
admet-376	281	17	but	but	CCONJ
admet-376	281	18	their	their	PRON
admet-376	281	19	molecular	molecular	ADJ
admet-376	281	20	nature	nature	NOUN
admet-376	281	21	(	(	PUNCT
admet-376	281	22	i.e.	i.e.	X
admet-376	281	23	identity	identity	NOUN
admet-376	281	24	)	)	PUNCT
admet-376	281	25	has	have	AUX
admet-376	281	26	not	not	PART
admet-376	281	27	yet	yet	ADV
admet-376	281	28	been	be	AUX
admet-376	281	29	determined	determine	VERB
admet-376	281	30	,	,	PUNCT
admet-376	281	31	e.g.	e.g.	ADV
admet-376	281	32	those	those	PRON
admet-376	281	33	for	for	ADP
admet-376	281	34	psychoactive	psychoactive	ADJ
admet-376	281	35	alkaloids	alkaloid	NOUN
admet-376	281	36	such	such	ADJ
admet-376	281	37	as	as	ADP
admet-376	281	38	cocaine	cocaine	NOUN
admet-376	281	39	[	[	X
admet-376	281	40	211	211	NUM
admet-376	281	41	]	]	PUNCT
admet-376	281	42	and	and	CCONJ
admet-376	281	43	nicotine	nicotine	VERB
admet-376	281	44	[	[	X
admet-376	281	45	212	212	NUM
admet-376	281	46	-	-	SYM
admet-376	281	47	216	216	NUM
admet-376	281	48	]	]	PUNCT
admet-376	281	49	and	and	CCONJ
admet-376	281	50	opioids	opioid	NOUN
admet-376	282	1	[	[	X
admet-376	282	2	217	217	NUM
admet-376	282	3	,	,	PUNCT
admet-376	282	4	218	218	NUM
admet-376	282	5	]	]	PUNCT
admet-376	282	6	.	.	PUNCT
admet-376	283	1	of	of	ADV
admet-376	283	2	course	course	NOUN
admet-376	283	3	many	many	ADJ
admet-376	283	4	transporters	transporter	NOUN
admet-376	283	5	are	be	AUX
admet-376	283	6	known	know	VERB
admet-376	283	7	in	in	ADP
admet-376	283	8	the	the	DET
admet-376	283	9	producer	producer	NOUN
admet-376	283	10	plants	plant	VERB
admet-376	283	11	themselves	themselves	PRON
admet-376	284	1	[	[	X
admet-376	284	2	163	163	NUM
admet-376	284	3	-	-	SYM
admet-376	284	4	165	165	NUM
admet-376	284	5	]	]	PUNCT
admet-376	284	6	.	.	PUNCT
admet-376	285	1	following	follow	VERB
admet-376	285	2	this	this	DET
admet-376	285	3	logic	logic	NOUN
admet-376	285	4	,	,	PUNCT
admet-376	285	5	the	the	DET
admet-376	285	6	prediction	prediction	NOUN
admet-376	285	7	,	,	PUNCT
admet-376	285	8	as	as	SCONJ
admet-376	285	9	tested	test	VERB
admet-376	285	10	here	here	ADV
admet-376	285	11	,	,	PUNCT
admet-376	285	12	is	be	AUX
admet-376	285	13	that	that	SCONJ
admet-376	285	14	at	at	ADV
admet-376	285	15	least	least	ADJ
admet-376	285	16	some	some	PRON
admet-376	285	17	successful	successful	ADJ
admet-376	285	18	marketed	market	VERB
admet-376	285	19	drugs	drug	NOUN
admet-376	285	20	should	should	AUX
admet-376	285	21	be	be	AUX
admet-376	285	22	much	much	ADV
admet-376	285	23	closer	close	ADJ
admet-376	285	24	to	to	ADP
admet-376	285	25	these	these	DET
admet-376	285	26	plant	plant	NOUN
admet-376	285	27	and	and	CCONJ
admet-376	285	28	microbial	microbial	ADJ
admet-376	285	29	molecules	molecule	NOUN
admet-376	285	30	in	in	ADP
admet-376	285	31	structural	structural	ADJ
admet-376	285	32	terms	term	NOUN
admet-376	285	33	than	than	SCONJ
admet-376	285	34	are	be	AUX
admet-376	285	35	the	the	DET
admet-376	285	36	intermediary	intermediary	ADJ
admet-376	285	37	metabolites	metabolite	NOUN
admet-376	285	38	that	that	PRON
admet-376	285	39	are	be	AUX
admet-376	285	40	part	part	NOUN
admet-376	285	41	of	of	ADP
admet-376	285	42	recon2	recon2	NOUN
admet-376	285	43	.	.	PUNCT
admet-376	286	1	the	the	DET
admet-376	286	2	prediction	prediction	NOUN
admet-376	286	3	was	be	AUX
admet-376	286	4	amply	amply	ADV
admet-376	286	5	demonstrated	demonstrate	VERB
admet-376	286	6	,	,	PUNCT
admet-376	286	7	and	and	CCONJ
admet-376	286	8	serves	serve	VERB
admet-376	286	9	to	to	PART
admet-376	286	10	account	account	VERB
admet-376	286	11	for	for	ADP
admet-376	286	12	the	the	DET
admet-376	286	13	otherwise	otherwise	ADV
admet-376	286	14	anomalous	anomalous	ADJ
admet-376	286	15	finding	finding	NOUN
admet-376	286	16	that	that	SCONJ
admet-376	286	17	only	only	ADV
admet-376	286	18	a	a	DET
admet-376	286	19	rather	rather	ADV
admet-376	286	20	small	small	ADJ
admet-376	286	21	fraction	fraction	NOUN
admet-376	286	22	of	of	ADP
admet-376	286	23	intermediary	intermediary	ADJ
admet-376	286	24	human	human	ADJ
admet-376	286	25	metabolites	metabolite	NOUN
admet-376	286	26	are	be	AUX
admet-376	286	27	reliably	reliably	ADV
admet-376	286	28	‘	'	PUNCT
admet-376	286	29	similar	similar	ADJ
admet-376	286	30	’	'	PUNCT
admet-376	286	31	(	(	PUNCT
admet-376	286	32	using	use	VERB
admet-376	286	33	the	the	DET
admet-376	286	34	maccs	maccs	NOUN
admet-376	286	35	/	/	SYM
admet-376	286	36	ts	ts	NOUN
admet-376	286	37	metric	metric	NOUN
admet-376	286	38	)	)	PUNCT
admet-376	286	39	to	to	PART
admet-376	286	40	marketed	market	VERB
admet-376	286	41	drugs	drug	NOUN
admet-376	286	42	at	at	ADP
admet-376	286	43	the	the	DET
admet-376	286	44	level	level	NOUN
admet-376	286	45	of	of	ADP
admet-376	286	46	0.75	0.75	NUM
admet-376	286	47	or	or	CCONJ
admet-376	286	48	0.8	0.8	NUM
admet-376	286	49	.	.	PUNCT
admet-376	287	1	however	however	ADV
admet-376	287	2	,	,	PUNCT
admet-376	287	3	by	by	ADP
admet-376	287	4	contrast	contrast	NOUN
admet-376	287	5	,	,	PUNCT
admet-376	287	6	we	we	PRON
admet-376	287	7	find	find	VERB
admet-376	287	8	that	that	SCONJ
admet-376	287	9	as	as	ADV
admet-376	287	10	many	many	ADJ
admet-376	287	11	as	as	ADP
admet-376	287	12	80	80	NUM
admet-376	287	13	%	%	NOUN
admet-376	287	14	of	of	ADP
admet-376	287	15	natural	natural	ADJ
admet-376	287	16	products	product	NOUN
admet-376	287	17	show	show	VERB
admet-376	287	18	such	such	DET
admet-376	287	19	a	a	DET
admet-376	287	20	similarity	similarity	NOUN
admet-376	287	21	when	when	SCONJ
admet-376	287	22	surveyed	survey	VERB
admet-376	287	23	extensively	extensively	ADV
admet-376	287	24	.	.	PUNCT
admet-376	288	1	this	this	PRON
admet-376	288	2	is	be	AUX
admet-376	288	3	consistent	consistent	ADJ
admet-376	288	4	with	with	ADP
admet-376	288	5	the	the	DET
admet-376	288	6	earlier	early	ADJ
admet-376	288	7	,	,	PUNCT
admet-376	288	8	pilot	pilot	NOUN
admet-376	288	9	findings	finding	NOUN
admet-376	288	10	(	(	PUNCT
admet-376	288	11	figure	figure	VERB
admet-376	288	12	5c	5c	NOUN
admet-376	288	13	of	of	ADP
admet-376	288	14	[	[	X
admet-376	288	15	22	22	NUM
admet-376	288	16	]	]	PUNCT
admet-376	288	17	)	)	PUNCT
admet-376	288	18	,	,	PUNCT
admet-376	288	19	and	and	CCONJ
admet-376	288	20	with	with	ADP
admet-376	288	21	the	the	DET
admet-376	288	22	fact	fact	NOUN
admet-376	288	23	that	that	SCONJ
admet-376	288	24	caco2	caco2	NOUN
admet-376	288	25	permeability	permeability	NOUN
admet-376	288	26	was	be	AUX
admet-376	288	27	poorly	poorly	ADV
admet-376	288	28	correlated	correlate	VERB
admet-376	288	29	with	with	ADP
admet-376	288	30	(	(	PUNCT
admet-376	288	31	the	the	DET
admet-376	288	32	maccs	maccs	PROPN
admet-376	288	33	encoding	encoding	PROPN
admet-376	288	34	of	of	ADP
admet-376	288	35	)	)	PUNCT
admet-376	288	36	endogenite	endogenite	NOUN
admet-376	288	37	-	-	PUNCT
admet-376	288	38	likeness	likeness	NOUN
admet-376	289	1	[	[	X
admet-376	289	2	15	15	NUM
admet-376	289	3	]	]	PUNCT
admet-376	289	4	.	.	PUNCT
admet-376	290	1	evolutionary	evolutionary	ADJ
admet-376	290	2	aspects	aspect	NOUN
admet-376	290	3	of	of	ADP
admet-376	290	4	‘	'	PUNCT
admet-376	290	5	secondary	secondary	ADJ
admet-376	290	6	metabolites	metabolite	NOUN
admet-376	290	7	’	'	PUNCT
admet-376	290	8	and	and	CCONJ
admet-376	290	9	other	other	ADJ
admet-376	290	10	natural	natural	ADJ
admet-376	290	11	products	product	NOUN
admet-376	290	12	the	the	DET
admet-376	290	13	question	question	NOUN
admet-376	290	14	of	of	ADP
admet-376	290	15	what	what	PRON
admet-376	290	16	roles	role	NOUN
admet-376	290	17	might	might	AUX
admet-376	290	18	be	be	AUX
admet-376	290	19	played	play	VERB
admet-376	290	20	by	by	ADP
admet-376	290	21	secondary	secondary	ADJ
admet-376	290	22	metabolites	metabolite	NOUN
admet-376	290	23	in	in	ADP
admet-376	290	24	evolutionary	evolutionary	ADJ
admet-376	290	25	terms	term	NOUN
admet-376	290	26	is	be	AUX
admet-376	290	27	an	an	DET
admet-376	290	28	old	old	ADJ
admet-376	290	29	one	one	NOUN
admet-376	290	30	,	,	PUNCT
admet-376	290	31	and	and	CCONJ
admet-376	290	32	almost	almost	ADV
admet-376	290	33	certainly	certainly	ADV
admet-376	290	34	does	do	AUX
admet-376	290	35	not	not	PART
admet-376	290	36	have	have	VERB
admet-376	290	37	a	a	DET
admet-376	290	38	unitary	unitary	ADJ
admet-376	290	39	answer	answer	NOUN
admet-376	290	40	.	.	PUNCT
admet-376	291	1	note	note	VERB
admet-376	291	2	that	that	SCONJ
admet-376	291	3	the	the	DET
admet-376	291	4	original	original	ADJ
admet-376	291	5	definition	definition	NOUN
admet-376	291	6	of	of	ADP
admet-376	291	7	‘	'	PUNCT
admet-376	291	8	secondary	secondary	ADJ
admet-376	291	9	metabolites	metabolite	NOUN
admet-376	291	10	’	'	PUNCT
admet-376	291	11	was	be	AUX
admet-376	291	12	to	to	ADP
admet-376	291	13	the	the	DET
admet-376	291	14	effect	effect	NOUN
admet-376	291	15	that	that	SCONJ
admet-376	291	16	only	only	ADV
admet-376	291	17	a	a	DET
admet-376	291	18	small	small	ADJ
admet-376	291	19	number	number	NOUN
admet-376	291	20	of	of	ADP
admet-376	291	21	organisms	organism	NOUN
admet-376	291	22	made	make	VERB
admet-376	291	23	a	a	DET
admet-376	291	24	given	give	VERB
admet-376	291	25	such	such	ADJ
admet-376	291	26	molecule	molecule	NOUN
admet-376	291	27	[	[	X
admet-376	291	28	219	219	NUM
admet-376	291	29	]	]	PUNCT
admet-376	291	30	.	.	PUNCT
admet-376	292	1	however	however	ADV
admet-376	292	2	,	,	PUNCT
admet-376	292	3	most	most	ADJ
admet-376	292	4	of	of	ADP
admet-376	292	5	this	this	DET
admet-376	292	6	literature	literature	NOUN
admet-376	292	7	on	on	ADP
admet-376	292	8	secondary	secondary	ADJ
admet-376	292	9	metabolites	metabolite	NOUN
admet-376	292	10	,	,	PUNCT
admet-376	292	11	taken	take	VERB
admet-376	292	12	as	as	ADP
admet-376	292	13	virtually	virtually	ADV
admet-376	292	14	synonymous	synonymous	ADJ
admet-376	292	15	with	with	ADP
admet-376	292	16	‘	'	PUNCT
admet-376	292	17	natural	natural	ADJ
admet-376	292	18	products	product	NOUN
admet-376	292	19	’	'	PUNCT
admet-376	292	20	,	,	PUNCT
admet-376	292	21	focuses	focus	VERB
admet-376	292	22	on	on	ADP
admet-376	292	23	the	the	DET
admet-376	292	24	benefits	benefit	NOUN
admet-376	292	25	to	to	PART
admet-376	292	26	be	be	AUX
admet-376	292	27	gained	gain	VERB
admet-376	292	28	by	by	ADP
admet-376	292	29	the	the	DET
admet-376	292	30	producer	producer	NOUN
admet-376	292	31	organisms	organism	NOUN
admet-376	292	32	themselves	themselves	PRON
admet-376	292	33	.	.	PUNCT
admet-376	293	1	to	to	ADP
admet-376	293	2	this	this	DET
admet-376	293	3	end	end	NOUN
admet-376	293	4	,	,	PUNCT
admet-376	293	5	there	there	PRON
admet-376	293	6	is	be	VERB
admet-376	293	7	abundant	abundant	ADJ
admet-376	293	8	evidence	evidence	NOUN
admet-376	293	9	that	that	SCONJ
admet-376	293	10	at	at	ADV
admet-376	293	11	least	least	ADJ
admet-376	293	12	some	some	DET
admet-376	293	13	natural	natural	ADJ
admet-376	293	14	products	product	NOUN
admet-376	293	15	are	be	AUX
admet-376	293	16	used	use	VERB
admet-376	293	17	as	as	ADP
admet-376	293	18	signals	signal	NOUN
admet-376	293	19	by	by	ADP
admet-376	293	20	(	(	PUNCT
admet-376	293	21	and	and	CCONJ
admet-376	293	22	towards	towards	ADP
admet-376	293	23	)	)	PUNCT
admet-376	293	24	other	other	ADJ
admet-376	293	25	individuals	individual	NOUN
admet-376	293	26	of	of	ADP
admet-376	293	27	the	the	DET
admet-376	293	28	same	same	ADJ
admet-376	293	29	species	specie	NOUN
admet-376	293	30	,	,	PUNCT
admet-376	293	31	and	and	CCONJ
admet-376	293	32	are	be	AUX
admet-376	293	33	thus	thus	ADV
admet-376	293	34	pheromones	pheromone	NOUN
admet-376	293	35	[	[	X
admet-376	293	36	220	220	NUM
admet-376	293	37	]	]	PUNCT
admet-376	293	38	.	.	PUNCT
admet-376	294	1	necessarily	necessarily	ADV
admet-376	294	2	,	,	PUNCT
admet-376	294	3	evolutionarily	evolutionarily	ADV
admet-376	294	4	early	early	ADJ
admet-376	294	5	variants	variant	NOUN
admet-376	294	6	of	of	ADP
admet-376	294	7	natural	natural	ADJ
admet-376	294	8	products	product	NOUN
admet-376	294	9	may	may	AUX
admet-376	294	10	lack	lack	VERB
admet-376	294	11	potency	potency	NOUN
admet-376	294	12	at	at	ADP
admet-376	294	13	the	the	DET
admet-376	294	14	concentrations	concentration	NOUN
admet-376	294	15	expressed	express	VERB
admet-376	294	16	[	[	X
admet-376	294	17	221	221	NUM
admet-376	294	18	]	]	PUNCT
admet-376	294	19	and	and	CCONJ
admet-376	294	20	the	the	DET
admet-376	294	21	fact	fact	NOUN
admet-376	294	22	that	that	SCONJ
admet-376	294	23	the	the	PRON
admet-376	294	24	wider	wide	ADJ
admet-376	294	25	the	the	DET
admet-376	294	26	number	number	NOUN
admet-376	294	27	produced	produce	VERB
admet-376	294	28	,	,	PUNCT
admet-376	294	29	the	the	PRON
admet-376	294	30	greater	great	ADJ
admet-376	294	31	the	the	DET
admet-376	294	32	likelihood	likelihood	NOUN
admet-376	294	33	of	of	ADP
admet-376	294	34	their	their	PRON
admet-376	294	35	selection	selection	NOUN
admet-376	294	36	[	[	X
admet-376	294	37	222	222	NUM
admet-376	294	38	]	]	PUNCT
admet-376	294	39	can	can	AUX
admet-376	294	40	explain	explain	VERB
admet-376	294	41	why	why	SCONJ
admet-376	294	42	the	the	DET
admet-376	294	43	selection	selection	NOUN
admet-376	294	44	pressure	pressure	NOUN
admet-376	294	45	,	,	PUNCT
admet-376	294	46	in	in	ADP
admet-376	294	47	terms	term	NOUN
admet-376	294	48	of	of	ADP
admet-376	294	49	benefitting	benefit	VERB
admet-376	294	50	the	the	DET
admet-376	294	51	producer	producer	NOUN
admet-376	294	52	,	,	PUNCT
admet-376	294	53	may	may	AUX
admet-376	294	54	often	often	ADV
admet-376	294	55	be	be	AUX
admet-376	294	56	quite	quite	ADV
admet-376	294	57	modest	modest	ADJ
admet-376	294	58	.	.	PUNCT
admet-376	295	1	however	however	ADV
admet-376	295	2	,	,	PUNCT
admet-376	295	3	our	our	PRON
admet-376	295	4	focus	focus	NOUN
admet-376	295	5	here	here	ADV
admet-376	295	6	is	be	AUX
admet-376	295	7	on	on	ADP
admet-376	295	8	the	the	DET
admet-376	295	9	benefits	benefit	NOUN
admet-376	295	10	to	to	ADP
admet-376	295	11	consumer	consumer	NOUN
admet-376	295	12	organisms	organism	NOUN
admet-376	295	13	.	.	PUNCT
admet-376	296	1	it	it	PRON
admet-376	296	2	now	now	ADV
admet-376	296	3	seems	seem	VERB
admet-376	296	4	clear	clear	ADJ
admet-376	296	5	that	that	SCONJ
admet-376	296	6	our	our	PRON
admet-376	296	7	earlier	early	ADJ
admet-376	296	8	focus	focus	NOUN
admet-376	296	9	[	[	X
admet-376	296	10	22	22	NUM
admet-376	296	11	-	-	SYM
admet-376	296	12	24	24	NUM
admet-376	296	13	,	,	PUNCT
admet-376	296	14	115	115	NUM
admet-376	296	15	]	]	PUNCT
admet-376	296	16	on	on	ADP
admet-376	296	17	transporters	transporter	NOUN
admet-376	296	18	just	just	ADV
admet-376	296	19	of	of	ADP
admet-376	296	20	human	human	NOUN
admet-376	296	21	-	-	PUNCT
admet-376	296	22	encoded	encode	VERB
admet-376	296	23	intermediary	intermediary	ADJ
admet-376	296	24	metabolites	metabolite	NOUN
admet-376	296	25	as	as	ADP
admet-376	296	26	the	the	DET
admet-376	296	27	potential	potential	ADJ
admet-376	296	28	source	source	NOUN
admet-376	296	29	of	of	ADP
admet-376	296	30	the	the	DET
admet-376	296	31	‘	'	PUNCT
admet-376	296	32	natural	natural	ADJ
admet-376	296	33	’	'	PUNCT
admet-376	296	34	substrates	substrate	NOUN
admet-376	296	35	of	of	ADP
admet-376	296	36	the	the	DET
admet-376	296	37	transporters	transporter	NOUN
admet-376	296	38	on	on	ADP
admet-376	296	39	which	which	PRON
admet-376	296	40	pharmaceutical	pharmaceutical	ADJ
admet-376	296	41	drugs	drug	NOUN
admet-376	296	42	hitchhike	hitchhike	VERB
admet-376	296	43	was	be	AUX
admet-376	296	44	somewhat	somewhat	ADV
admet-376	296	45	misplaced	misplaced	ADJ
admet-376	296	46	.	.	PUNCT
admet-376	297	1	this	this	PRON
admet-376	297	2	is	be	AUX
admet-376	297	3	because	because	SCONJ
admet-376	297	4	humans	human	NOUN
admet-376	297	5	,	,	PUNCT
admet-376	297	6	and	and	CCONJ
admet-376	297	7	at	at	ADP
admet-376	297	8	least	least	ADJ
admet-376	297	9	their	their	PRON
admet-376	297	10	vertebrate	vertebrate	NOUN
admet-376	297	11	(	(	PUNCT
admet-376	297	12	and	and	CCONJ
admet-376	297	13	indeed	indeed	ADV
admet-376	297	14	invertebrate	invertebrate	VERB
admet-376	297	15	)	)	PUNCT
admet-376	297	16	evolutionary	evolutionary	ADJ
admet-376	297	17	predecessors	predecessor	NOUN
admet-376	297	18	,	,	PUNCT
admet-376	297	19	have	have	AUX
admet-376	297	20	been	be	AUX
admet-376	297	21	exposed	expose	VERB
admet-376	297	22	for	for	ADP
admet-376	297	23	millions	million	NOUN
admet-376	297	24	of	of	ADP
admet-376	297	25	years	year	NOUN
admet-376	297	26	to	to	PART
admet-376	297	27	plantand	plantand	VERB
admet-376	297	28	microbe	microbe	NOUN
admet-376	297	29	-	-	PUNCT
admet-376	297	30	based	base	VERB
admet-376	297	31	dietary	dietary	ADJ
admet-376	297	32	substances	substance	NOUN
admet-376	297	33	that	that	PRON
admet-376	297	34	had	have	VERB
admet-376	297	35	bioactivities	bioactivitie	NOUN
admet-376	297	36	of	of	ADP
admet-376	297	37	various	various	ADJ
admet-376	297	38	kinds	kind	NOUN
admet-376	297	39	,	,	PUNCT
admet-376	297	40	many	many	ADJ
admet-376	297	41	of	of	ADP
admet-376	297	42	which	which	PRON
admet-376	297	43	must	must	AUX
admet-376	297	44	admet	admet	PROPN
admet-376	297	45	&	&	CCONJ
admet-376	297	46	dmpk	dmpk	PROPN
admet-376	297	47	5(2	5(2	NUM
admet-376	297	48	)	)	PUNCT
admet-376	297	49	(	(	PUNCT
admet-376	297	50	2017	2017	NUM
admet-376	297	51	)	)	PUNCT
admet-376	297	52	85	85	NUM
admet-376	297	53	-	-	SYM
admet-376	297	54	125	125	NUM
admet-376	297	55	exogenous	exogenous	ADJ
admet-376	297	56	natural	natural	ADJ
admet-376	297	57	products	product	NOUN
admet-376	297	58	as	as	ADP
admet-376	297	59	‘	'	PUNCT
admet-376	297	60	natural	natural	ADJ
admet-376	297	61	’	'	PUNCT
admet-376	297	62	drug	drug	NOUN
admet-376	297	63	transporter	transporter	NOUN
admet-376	297	64	substrates	substrate	VERB
admet-376	297	65	doi	doi	NOUN
admet-376	297	66	:	:	PUNCT
admet-376	297	67	10.5599	10.5599	NUM
admet-376	297	68	/	/	SYM
admet-376	297	69	admet.5.2.376	admet.5.2.376	PROPN
admet-376	297	70	113	113	NUM
admet-376	297	71	have	have	AUX
admet-376	297	72	been	be	AUX
admet-376	297	73	beneficial	beneficial	ADJ
admet-376	297	74	and	and	CCONJ
admet-376	297	75	thus	thus	ADV
admet-376	297	76	conferred	confer	VERB
admet-376	297	77	a	a	DET
admet-376	297	78	selective	selective	ADJ
admet-376	297	79	advantage	advantage	NOUN
admet-376	297	80	,	,	PUNCT
admet-376	297	81	however	however	ADV
admet-376	297	82	small	small	ADJ
admet-376	297	83	[	[	X
admet-376	297	84	223	223	NUM
admet-376	297	85	,	,	PUNCT
admet-376	297	86	224	224	NUM
admet-376	297	87	]	]	PUNCT
admet-376	297	88	,	,	PUNCT
admet-376	297	89	on	on	ADP
admet-376	297	90	the	the	DET
admet-376	297	91	host	host	NOUN
admet-376	297	92	.	.	PUNCT
admet-376	298	1	the	the	DET
admet-376	298	2	origins	origin	NOUN
admet-376	298	3	of	of	ADP
admet-376	298	4	this	this	PRON
admet-376	298	5	remain	remain	VERB
admet-376	298	6	uncertain	uncertain	ADJ
admet-376	298	7	,	,	PUNCT
admet-376	298	8	but	but	CCONJ
admet-376	298	9	the	the	DET
admet-376	298	10	early	early	ADJ
admet-376	298	11	ones	one	NOUN
admet-376	298	12	(	(	PUNCT
admet-376	298	13	ca	ca	PROPN
admet-376	298	14	1.8gy	1.8gy	PROPN
admet-376	298	15	bp	bp	PROPN
admet-376	298	16	)	)	PUNCT
admet-376	298	17	may	may	AUX
admet-376	298	18	have	have	AUX
admet-376	298	19	involved	involve	VERB
admet-376	298	20	simple	simple	ADJ
admet-376	298	21	engulfment	engulfment	NOUN
admet-376	299	1	[	[	X
admet-376	299	2	225	225	NUM
admet-376	299	3	]	]	PUNCT
admet-376	299	4	,	,	PUNCT
admet-376	299	5	with	with	ADP
admet-376	299	6	major	major	ADJ
admet-376	299	7	eukaryote	eukaryote	NOUN
admet-376	299	8	diversity	diversity	NOUN
admet-376	299	9	set	set	VERB
admet-376	299	10	in	in	ADP
admet-376	299	11	place	place	NOUN
admet-376	299	12	by	by	ADP
admet-376	299	13	800my	800my	PROPN
admet-376	299	14	bp	bp	PROPN
admet-376	300	1	[	[	X
admet-376	300	2	226	226	NUM
admet-376	300	3	]	]	PUNCT
admet-376	300	4	.	.	PUNCT
admet-376	301	1	even	even	ADV
admet-376	301	2	if	if	SCONJ
admet-376	301	3	one	one	PRON
admet-376	301	4	considers	consider	VERB
admet-376	301	5	only	only	ADJ
admet-376	301	6	angiosperms	angiosperm	NOUN
admet-376	301	7	as	as	ADP
admet-376	301	8	potential	potential	ADJ
admet-376	301	9	sources	source	NOUN
admet-376	301	10	of	of	ADP
admet-376	301	11	nutrients	nutrient	NOUN
admet-376	301	12	,	,	PUNCT
admet-376	301	13	these	these	PRON
admet-376	301	14	begin	begin	VERB
admet-376	301	15	to	to	PART
admet-376	301	16	arise	arise	VERB
admet-376	301	17	ca	can	AUX
admet-376	301	18	133	133	NUM
admet-376	301	19	my	my	PRON
admet-376	301	20	bp	bp	PROPN
admet-376	302	1	[	[	X
admet-376	302	2	227	227	NUM
admet-376	302	3	]	]	PUNCT
admet-376	302	4	(	(	PUNCT
admet-376	302	5	with	with	ADP
admet-376	302	6	solanaceae	solanaceae	NOUN
admet-376	302	7	at	at	ADP
admet-376	302	8	around	around	ADP
admet-376	302	9	half	half	DET
admet-376	302	10	that	that	DET
admet-376	302	11	period	period	NOUN
admet-376	302	12	bp	bp	PROPN
admet-376	303	1	[	[	X
admet-376	303	2	228	228	NUM
admet-376	303	3	]	]	PUNCT
admet-376	303	4	)	)	PUNCT
admet-376	303	5	.	.	PUNCT
admet-376	304	1	thus	thus	ADV
admet-376	304	2	,	,	PUNCT
admet-376	304	3	the	the	DET
admet-376	304	4	need	need	NOUN
admet-376	304	5	(	(	PUNCT
admet-376	304	6	and	and	CCONJ
admet-376	304	7	ability	ability	NOUN
admet-376	304	8	)	)	PUNCT
admet-376	304	9	to	to	PART
admet-376	304	10	take	take	VERB
admet-376	304	11	up	up	ADP
admet-376	304	12	plant	plant	NOUN
admet-376	304	13	and	and	CCONJ
admet-376	304	14	microbial	microbial	ADJ
admet-376	304	15	metabolites	metabolite	NOUN
admet-376	304	16	is	be	AUX
admet-376	304	17	likely	likely	ADJ
admet-376	304	18	a	a	DET
admet-376	304	19	trait	trait	NOUN
admet-376	304	20	of	of	ADP
admet-376	304	21	rather	rather	ADV
admet-376	304	22	ancient	ancient	ADJ
admet-376	304	23	origin	origin	NOUN
admet-376	304	24	.	.	PUNCT
admet-376	305	1	transporter	transporter	NOUN
admet-376	305	2	phylogenetics	phylogenetic	NOUN
admet-376	305	3	transporter	transporter	NOUN
admet-376	305	4	phylogenetics	phylogenetic	NOUN
admet-376	305	5	is	be	AUX
admet-376	305	6	an	an	DET
admet-376	305	7	area	area	NOUN
admet-376	305	8	that	that	PRON
admet-376	305	9	is	be	AUX
admet-376	305	10	still	still	ADV
admet-376	305	11	highly	highly	ADV
admet-376	305	12	under	under	ADV
admet-376	305	13	-	-	PUNCT
admet-376	305	14	researched	research	VERB
admet-376	305	15	[	[	X
admet-376	305	16	229	229	NUM
admet-376	305	17	]	]	PUNCT
admet-376	305	18	(	(	PUNCT
admet-376	305	19	as	as	SCONJ
admet-376	305	20	are	be	AUX
admet-376	305	21	transporters	transporter	NOUN
admet-376	305	22	in	in	ADP
admet-376	305	23	general	general	ADJ
admet-376	305	24	[	[	X
admet-376	305	25	12	12	NUM
admet-376	305	26	]	]	NUM
admet-376	305	27	)	)	PUNCT
admet-376	305	28	,	,	PUNCT
admet-376	305	29	and	and	CCONJ
admet-376	305	30	indeed	indeed	ADV
admet-376	305	31	nearly	nearly	ADV
admet-376	305	32	100	100	NUM
admet-376	305	33	new	new	ADJ
admet-376	305	34	families	family	NOUN
admet-376	305	35	are	be	AUX
admet-376	305	36	introduced	introduce	VERB
admet-376	305	37	into	into	ADP
admet-376	305	38	the	the	DET
admet-376	305	39	transporter	transporter	NOUN
admet-376	305	40	classification	classification	NOUN
admet-376	305	41	database	database	NOUN
admet-376	305	42	(	(	PUNCT
admet-376	305	43	tcdb	tcdb	NOUN
admet-376	305	44	)	)	PUNCT
admet-376	305	45	every	every	DET
admet-376	305	46	year	year	NOUN
admet-376	305	47	[	[	X
admet-376	305	48	230	230	NUM
admet-376	305	49	]	]	PUNCT
admet-376	305	50	.	.	PUNCT
admet-376	306	1	this	this	PRON
admet-376	306	2	is	be	AUX
admet-376	306	3	not	not	PART
admet-376	306	4	the	the	DET
admet-376	306	5	place	place	NOUN
admet-376	306	6	to	to	PART
admet-376	306	7	pursue	pursue	VERB
admet-376	306	8	that	that	DET
admet-376	306	9	issue	issue	NOUN
admet-376	306	10	in	in	ADP
admet-376	306	11	detail	detail	NOUN
admet-376	306	12	,	,	PUNCT
admet-376	306	13	so	so	CCONJ
admet-376	306	14	a	a	DET
admet-376	306	15	single	single	ADJ
admet-376	306	16	example	example	NOUN
admet-376	306	17	will	will	AUX
admet-376	306	18	suffice	suffice	VERB
admet-376	306	19	:	:	PUNCT
admet-376	306	20	a	a	DET
admet-376	306	21	blast	blast	NOUN
admet-376	306	22	search	search	NOUN
admet-376	306	23	of	of	ADP
admet-376	306	24	the	the	DET
admet-376	306	25	sequence	sequence	NOUN
admet-376	306	26	for	for	ADP
admet-376	306	27	human	human	ADJ
admet-376	306	28	slc22a4	slc22a4	NOUN
admet-376	306	29	,	,	PUNCT
admet-376	306	30	the	the	DET
admet-376	306	31	ergothioneine	ergothioneine	NOUN
admet-376	306	32	transporter	transporter	NOUN
admet-376	306	33	,	,	PUNCT
admet-376	306	34	reveals	reveal	VERB
admet-376	306	35	(	(	PUNCT
admet-376	306	36	data	datum	NOUN
admet-376	306	37	not	not	PART
admet-376	306	38	shown	show	VERB
admet-376	306	39	)	)	PUNCT
admet-376	306	40	that	that	SCONJ
admet-376	306	41	it	it	PRON
admet-376	306	42	is	be	AUX
admet-376	306	43	widespread	widespread	ADJ
admet-376	306	44	among	among	ADP
admet-376	306	45	modern	modern	ADJ
admet-376	306	46	mammals	mammal	NOUN
admet-376	306	47	,	,	PUNCT
admet-376	306	48	but	but	CCONJ
admet-376	306	49	obvious	obvious	ADJ
admet-376	306	50	homologues	homologue	NOUN
admet-376	306	51	are	be	AUX
admet-376	306	52	not	not	PART
admet-376	306	53	to	to	PART
admet-376	306	54	be	be	AUX
admet-376	306	55	found	find	VERB
admet-376	306	56	in	in	ADP
admet-376	306	57	reptiles	reptile	NOUN
admet-376	306	58	,	,	PUNCT
admet-376	306	59	fishes	fish	NOUN
admet-376	306	60	,	,	PUNCT
admet-376	306	61	or	or	CCONJ
admet-376	306	62	lower	low	ADJ
admet-376	306	63	taxa	taxa	NOUN
admet-376	306	64	.	.	PUNCT
admet-376	307	1	we	we	PRON
admet-376	307	2	also	also	ADV
admet-376	307	3	note	note	VERB
admet-376	307	4	here	here	ADV
admet-376	307	5	that	that	SCONJ
admet-376	307	6	we	we	PRON
admet-376	307	7	have	have	AUX
admet-376	307	8	confined	confine	VERB
admet-376	307	9	our	our	PRON
admet-376	307	10	thinking	thinking	NOUN
admet-376	307	11	here	here	ADV
admet-376	307	12	to	to	ADP
admet-376	307	13	‘	'	PUNCT
admet-376	307	14	uptake	uptake	ADJ
admet-376	307	15	’	'	PUNCT
admet-376	307	16	transporters	transporter	NOUN
admet-376	307	17	of	of	ADP
admet-376	307	18	the	the	DET
admet-376	307	19	slc	slc	PROPN
admet-376	307	20	families	family	NOUN
admet-376	307	21	,	,	PUNCT
admet-376	307	22	and	and	CCONJ
admet-376	307	23	not	not	PART
admet-376	307	24	discussed	discuss	VERB
admet-376	307	25	the	the	DET
admet-376	307	26	abc	abc	PROPN
admet-376	307	27	families	family	NOUN
admet-376	307	28	mainly	mainly	ADV
admet-376	307	29	involved	involve	VERB
admet-376	307	30	in	in	ADP
admet-376	307	31	efflux	efflux	NOUN
admet-376	307	32	(	(	PUNCT
admet-376	308	1	e.g.	e.g.	ADV
admet-376	308	2	[	[	X
admet-376	308	3	231	231	NUM
admet-376	308	4	-	-	SYM
admet-376	308	5	234	234	NUM
admet-376	308	6	]	]	PUNCT
admet-376	308	7	)	)	PUNCT
admet-376	308	8	.	.	PUNCT
admet-376	309	1	we	we	PRON
admet-376	309	2	have	have	AUX
admet-376	309	3	also	also	ADV
admet-376	309	4	ignored	ignore	VERB
admet-376	309	5	completely	completely	ADV
admet-376	309	6	the	the	DET
admet-376	309	7	highly	highly	ADV
admet-376	309	8	heterogeneous	heterogeneous	ADJ
admet-376	309	9	tissue	tissue	NOUN
admet-376	309	10	distributions	distribution	NOUN
admet-376	309	11	of	of	ADP
admet-376	309	12	the	the	DET
admet-376	309	13	different	different	ADJ
admet-376	309	14	transporters	transporter	NOUN
admet-376	309	15	(	(	PUNCT
admet-376	309	16	e.g.	e.g.	ADV
admet-376	309	17	[	[	X
admet-376	309	18	235	235	NUM
admet-376	309	19	,	,	PUNCT
admet-376	309	20	236	236	NUM
admet-376	309	21	]	]	PUNCT
admet-376	309	22	)	)	PUNCT
admet-376	309	23	.	.	PUNCT
admet-376	310	1	future	future	ADJ
admet-376	310	2	work	work	NOUN
admet-376	310	3	will	will	AUX
admet-376	310	4	benefit	benefit	VERB
admet-376	310	5	from	from	ADP
admet-376	310	6	incorporation	incorporation	NOUN
admet-376	310	7	of	of	ADP
admet-376	310	8	both	both	DET
admet-376	310	9	these	these	DET
admet-376	310	10	features	feature	NOUN
admet-376	310	11	.	.	PUNCT
admet-376	311	1	drugs	drug	NOUN
admet-376	311	2	and	and	CCONJ
admet-376	311	3	natural	natural	ADJ
admet-376	311	4	products	product	NOUN
admet-376	311	5	it	it	PRON
admet-376	311	6	is	be	AUX
admet-376	311	7	,	,	PUNCT
admet-376	311	8	of	of	ADP
admet-376	311	9	course	course	NOUN
admet-376	311	10	,	,	PUNCT
admet-376	311	11	well	well	INTJ
admet-376	311	12	known	know	VERB
admet-376	311	13	that	that	SCONJ
admet-376	311	14	many	many	ADJ
admet-376	311	15	natural	natural	ADJ
admet-376	311	16	products	product	NOUN
admet-376	311	17	can	can	AUX
admet-376	311	18	serve	serve	VERB
admet-376	311	19	as	as	ADP
admet-376	311	20	medicines	medicine	NOUN
admet-376	311	21	[	[	X
admet-376	311	22	88	88	NUM
admet-376	311	23	,	,	PUNCT
admet-376	311	24	237	237	NUM
admet-376	311	25	]	]	PUNCT
admet-376	311	26	,	,	PUNCT
admet-376	311	27	and	and	CCONJ
admet-376	311	28	that	that	SCONJ
admet-376	311	29	many	many	ADJ
admet-376	311	30	purified	purified	ADJ
admet-376	311	31	substances	substance	NOUN
admet-376	311	32	derived	derive	VERB
admet-376	311	33	therefrom	therefrom	NOUN
admet-376	311	34	are	be	AUX
admet-376	311	35	the	the	DET
admet-376	311	36	basis	basis	NOUN
admet-376	311	37	of	of	ADP
admet-376	311	38	a	a	DET
admet-376	311	39	significant	significant	ADJ
admet-376	311	40	fraction	fraction	NOUN
admet-376	311	41	–	–	PUNCT
admet-376	311	42	probably	probably	ADV
admet-376	311	43	35	35	NUM
admet-376	311	44	-	-	SYM
admet-376	311	45	60	60	NUM
admet-376	311	46	%	%	NOUN
admet-376	311	47	depending	depend	VERB
admet-376	311	48	on	on	ADP
admet-376	311	49	how	how	SCONJ
admet-376	311	50	one	one	NUM
admet-376	311	51	counts	count	NOUN
admet-376	311	52	–	–	PUNCT
admet-376	311	53	of	of	ADP
admet-376	311	54	marketed	market	VERB
admet-376	311	55	drugs	drug	NOUN
admet-376	311	56	(	(	PUNCT
admet-376	311	57	see	see	VERB
admet-376	311	58	above	above	ADV
admet-376	311	59	,	,	PUNCT
admet-376	311	60	and	and	CCONJ
admet-376	311	61	[	[	X
admet-376	311	62	158	158	NUM
admet-376	311	63	,	,	PUNCT
admet-376	311	64	238	238	NUM
admet-376	311	65	-	-	SYM
admet-376	311	66	240	240	NUM
admet-376	311	67	]	]	PUNCT
admet-376	311	68	)	)	PUNCT
admet-376	311	69	.	.	PUNCT
admet-376	312	1	we	we	PRON
admet-376	312	2	think	think	VERB
admet-376	312	3	that	that	SCONJ
admet-376	312	4	the	the	DET
admet-376	312	5	present	present	ADJ
admet-376	312	6	work	work	NOUN
admet-376	312	7	highlights	highlight	NOUN
admet-376	312	8	even	even	ADV
admet-376	312	9	more	more	ADV
admet-376	312	10	clearly	clearly	ADV
admet-376	312	11	how	how	SCONJ
admet-376	312	12	important	important	ADJ
admet-376	312	13	natural	natural	ADJ
admet-376	312	14	products	product	NOUN
admet-376	312	15	and	and	CCONJ
admet-376	312	16	their	their	PRON
admet-376	312	17	derivatives	derivative	NOUN
admet-376	312	18	are	be	AUX
admet-376	312	19	likely	likely	ADJ
admet-376	312	20	to	to	PART
admet-376	312	21	be	be	AUX
admet-376	312	22	in	in	ADP
admet-376	312	23	terms	term	NOUN
admet-376	312	24	of	of	ADP
admet-376	312	25	producing	produce	VERB
admet-376	312	26	novel	novel	NOUN
admet-376	312	27	,	,	PUNCT
admet-376	312	28	safe	safe	ADJ
admet-376	312	29	and	and	CCONJ
admet-376	312	30	efficacious	efficacious	ADJ
admet-376	312	31	drugs	drug	NOUN
admet-376	312	32	.	.	PUNCT
admet-376	313	1	conclusions	conclusion	NOUN
admet-376	313	2	the	the	DET
admet-376	313	3	present	present	ADJ
admet-376	313	4	analysis	analysis	NOUN
admet-376	313	5	takes	take	VERB
admet-376	313	6	forward	forward	ADV
admet-376	313	7	our	our	PRON
admet-376	313	8	continuing	continue	VERB
admet-376	313	9	analysis	analysis	NOUN
admet-376	313	10	of	of	ADP
admet-376	313	11	the	the	DET
admet-376	313	12	structural	structural	ADJ
admet-376	313	13	similarities	similarity	NOUN
admet-376	313	14	between	between	ADP
admet-376	313	15	marketed	market	VERB
admet-376	313	16	drugs	drug	NOUN
admet-376	313	17	and	and	CCONJ
admet-376	313	18	naturally	naturally	ADV
admet-376	313	19	occurring	occur	VERB
admet-376	313	20	substances	substance	NOUN
admet-376	313	21	in	in	ADP
admet-376	313	22	two	two	NUM
admet-376	313	23	major	major	ADJ
admet-376	313	24	ways	way	NOUN
admet-376	313	25	.	.	PUNCT
admet-376	314	1	first	first	ADV
admet-376	314	2	,	,	PUNCT
admet-376	314	3	by	by	ADP
admet-376	314	4	looking	look	VERB
admet-376	314	5	at	at	ADP
admet-376	314	6	rank	rank	NOUN
admet-376	314	7	orders	order	NOUN
admet-376	314	8	of	of	ADP
admet-376	314	9	similarities	similarity	NOUN
admet-376	314	10	between	between	ADP
admet-376	314	11	encodings	encoding	NOUN
admet-376	314	12	,	,	PUNCT
admet-376	314	13	we	we	PRON
admet-376	314	14	find	find	VERB
admet-376	314	15	very	very	ADV
admet-376	314	16	major	major	ADJ
admet-376	314	17	differences	difference	NOUN
admet-376	314	18	,	,	PUNCT
admet-376	314	19	such	such	ADJ
admet-376	314	20	that	that	SCONJ
admet-376	314	21	the	the	DET
admet-376	314	22	metabolite	metabolite	NOUN
admet-376	314	23	with	with	ADP
admet-376	314	24	the	the	DET
admet-376	314	25	closest	close	ADJ
admet-376	314	26	ts	ts	NOUN
admet-376	314	27	to	to	ADP
admet-376	314	28	a	a	DET
admet-376	314	29	drug	drug	NOUN
admet-376	314	30	in	in	ADP
admet-376	314	31	one	one	NUM
admet-376	314	32	encoding	encoding	NOUN
admet-376	314	33	may	may	AUX
admet-376	314	34	be	be	AUX
admet-376	314	35	very	very	ADV
admet-376	314	36	different	different	ADJ
admet-376	314	37	in	in	ADP
admet-376	314	38	both	both	PRON
admet-376	314	39	nature	nature	NOUN
admet-376	314	40	and	and	CCONJ
admet-376	314	41	ts	ts	ADP
admet-376	314	42	value	value	NOUN
admet-376	314	43	from	from	ADP
admet-376	314	44	that	that	PRON
admet-376	314	45	when	when	SCONJ
admet-376	314	46	compared	compare	VERB
admet-376	314	47	with	with	ADP
admet-376	314	48	another	another	DET
admet-376	314	49	encoding	encoding	NOUN
admet-376	314	50	.	.	PUNCT
admet-376	315	1	there	there	PRON
admet-376	315	2	is	be	VERB
admet-376	315	3	no	no	DET
admet-376	315	4	encoding	encoding	NOUN
admet-376	315	5	that	that	PRON
admet-376	315	6	seems	seem	VERB
admet-376	315	7	to	to	ADP
admet-376	315	8	us	we	PRON
admet-376	315	9	to	to	PART
admet-376	315	10	have	have	VERB
admet-376	315	11	any	any	DET
admet-376	315	12	special	special	ADJ
admet-376	315	13	intellectual	intellectual	ADJ
admet-376	315	14	privileges	privilege	NOUN
admet-376	315	15	,	,	PUNCT
admet-376	315	16	and	and	CCONJ
admet-376	315	17	as	as	SCONJ
admet-376	315	18	stressed	stress	VERB
admet-376	315	19	by	by	ADP
admet-376	315	20	everitt	everitt	PROPN
admet-376	315	21	[	[	X
admet-376	315	22	241	241	NUM
admet-376	315	23	]	]	X
admet-376	315	24	unsupervised	unsupervised	ADJ
admet-376	315	25	analyses	analysis	NOUN
admet-376	315	26	should	should	AUX
admet-376	315	27	anyway	anyway	ADV
admet-376	315	28	best	well	ADV
admet-376	315	29	be	be	AUX
admet-376	315	30	judged	judge	VERB
admet-376	315	31	simply	simply	ADV
admet-376	315	32	on	on	ADP
admet-376	315	33	their	their	PRON
admet-376	315	34	utility	utility	NOUN
admet-376	315	35	.	.	PUNCT
admet-376	316	1	on	on	ADP
admet-376	316	2	this	this	DET
admet-376	316	3	basis	basis	NOUN
admet-376	316	4	,	,	PUNCT
admet-376	316	5	we	we	PRON
admet-376	316	6	consider	consider	VERB
admet-376	316	7	it	it	PRON
admet-376	316	8	entirely	entirely	ADV
admet-376	316	9	legitimate	legitimate	ADJ
admet-376	316	10	to	to	PART
admet-376	316	11	pick	pick	VERB
admet-376	316	12	and	and	CCONJ
admet-376	316	13	choose	choose	VERB
admet-376	316	14	encodings	encoding	NOUN
admet-376	316	15	to	to	PART
admet-376	316	16	maximise	maximise	VERB
admet-376	316	17	apparent	apparent	ADJ
admet-376	316	18	similarities	similarity	NOUN
admet-376	316	19	,	,	PUNCT
admet-376	316	20	as	as	ADP
admet-376	316	21	a	a	DET
admet-376	316	22	guide	guide	NOUN
admet-376	316	23	to	to	ADP
admet-376	316	24	testing	testing	NOUN
admet-376	316	25	,	,	PUNCT
admet-376	316	26	for	for	ADP
admet-376	316	27	instance	instance	NOUN
admet-376	316	28	,	,	PUNCT
admet-376	316	29	which	which	PRON
admet-376	316	30	other	other	ADJ
admet-376	316	31	substances	substance	NOUN
admet-376	316	32	are	be	AUX
admet-376	316	33	competing	compete	VERB
admet-376	316	34	substrates	substrate	NOUN
admet-376	316	35	for	for	ADP
admet-376	316	36	the	the	DET
admet-376	316	37	transport	transport	NOUN
admet-376	316	38	of	of	ADP
admet-376	316	39	a	a	DET
admet-376	316	40	particular	particular	ADJ
admet-376	316	41	drug	drug	NOUN
admet-376	316	42	.	.	PUNCT
admet-376	317	1	previously	previously	ADV
admet-376	317	2	,	,	PUNCT
admet-376	317	3	we	we	PRON
admet-376	317	4	focussed	focusse	VERB
admet-376	317	5	solely	solely	ADV
admet-376	317	6	on	on	ADP
admet-376	317	7	human	human	ADJ
admet-376	317	8	endogenites	endogenite	NOUN
admet-376	317	9	and	and	CCONJ
admet-376	317	10	the	the	DET
admet-376	317	11	contents	content	NOUN
admet-376	317	12	of	of	ADP
admet-376	317	13	recon2	recon2	NOUN
admet-376	317	14	when	when	SCONJ
admet-376	317	15	making	make	VERB
admet-376	317	16	these	these	DET
admet-376	317	17	comparisons	comparison	NOUN
admet-376	317	18	.	.	PUNCT
admet-376	318	1	however	however	ADV
admet-376	318	2	,	,	PUNCT
admet-376	318	3	not	not	PART
admet-376	318	4	least	least	ADJ
admet-376	318	5	because	because	SCONJ
admet-376	318	6	of	of	ADP
admet-376	318	7	the	the	DET
admet-376	318	8	discovery	discovery	NOUN
admet-376	318	9	by	by	ADP
admet-376	318	10	gründemann	gründemann	PROPN
admet-376	318	11	and	and	CCONJ
admet-376	318	12	colleagues	colleague	NOUN
admet-376	319	1	[	[	X
admet-376	319	2	65	65	NUM
admet-376	319	3	,	,	PUNCT
admet-376	319	4	66	66	NUM
admet-376	319	5	]	]	PUNCT
admet-376	319	6	that	that	SCONJ
admet-376	319	7	slc22a4	slc22a4	PROPN
admet-376	319	8	is	be	AUX
admet-376	319	9	in	in	ADP
admet-376	319	10	fact	fact	NOUN
admet-376	319	11	an	an	DET
admet-376	319	12	ergothioneine	ergothioneine	NOUN
admet-376	319	13	transporter	transporter	NOUN
admet-376	319	14	,	,	PUNCT
admet-376	319	15	we	we	PRON
admet-376	319	16	now	now	ADV
admet-376	319	17	recognise	recognise	VERB
admet-376	319	18	that	that	SCONJ
admet-376	319	19	we	we	PRON
admet-376	319	20	should	should	AUX
admet-376	319	21	include	include	VERB
admet-376	319	22	all	all	DET
admet-376	319	23	kinds	kind	NOUN
admet-376	319	24	of	of	ADP
admet-376	319	25	plant	plant	NOUN
admet-376	319	26	and	and	CCONJ
admet-376	319	27	microbial	microbial	ADJ
admet-376	319	28	(	(	PUNCT
admet-376	319	29	and	and	CCONJ
admet-376	319	30	any	any	DET
admet-376	319	31	other	other	ADJ
admet-376	319	32	)	)	PUNCT
admet-376	319	33	natural	natural	ADJ
admet-376	319	34	products	product	NOUN
admet-376	319	35	to	to	PART
admet-376	319	36	which	which	PRON
admet-376	319	37	humans	human	NOUN
admet-376	319	38	might	might	AUX
admet-376	319	39	have	have	AUX
admet-376	319	40	been	be	AUX
admet-376	319	41	exposed	expose	VERB
admet-376	319	42	in	in	ADP
admet-376	319	43	evolution	evolution	NOUN
admet-376	319	44	,	,	PUNCT
admet-376	319	45	and	and	CCONJ
admet-376	319	46	transport	transport	NOUN
admet-376	319	47	of	of	ADP
admet-376	319	48	whose	whose	DET
admet-376	319	49	bioactive	bioactive	ADJ
admet-376	319	50	principles	principle	NOUN
admet-376	319	51	might	might	AUX
admet-376	319	52	have	have	AUX
admet-376	319	53	been	be	AUX
admet-376	319	54	selected	select	VERB
admet-376	319	55	adaptively	adaptively	ADV
admet-376	319	56	on	on	ADP
admet-376	319	57	the	the	DET
admet-376	319	58	basis	basis	NOUN
admet-376	319	59	of	of	ADP
admet-376	319	60	their	their	PRON
admet-376	319	61	nutritional	nutritional	ADJ
admet-376	319	62	or	or	CCONJ
admet-376	319	63	medicinal	medicinal	ADJ
admet-376	319	64	activities	activity	NOUN
admet-376	319	65	and	and	CCONJ
admet-376	319	66	benefits	benefit	NOUN
admet-376	319	67	.	.	PUNCT
admet-376	320	1	clearly	clearly	ADV
admet-376	320	2	,	,	PUNCT
admet-376	320	3	natural	natural	ADJ
admet-376	320	4	evolution	evolution	NOUN
admet-376	320	5	may	may	AUX
admet-376	320	6	be	be	AUX
admet-376	320	7	expected	expect	VERB
admet-376	320	8	to	to	PART
admet-376	320	9	have	have	AUX
admet-376	320	10	selected	select	VERB
admet-376	320	11	for	for	ADP
admet-376	320	12	the	the	DET
admet-376	320	13	ability	ability	NOUN
admet-376	320	14	to	to	PART
admet-376	320	15	transport	transport	VERB
admet-376	320	16	molecules	molecule	NOUN
admet-376	320	17	that	that	PRON
admet-376	320	18	in	in	ADP
admet-376	320	19	kind	kind	NOUN
admet-376	320	20	and	and	CCONJ
admet-376	320	21	amount	amount	NOUN
admet-376	320	22	were	be	AUX
admet-376	320	23	of	of	ADP
admet-376	320	24	benefit	benefit	NOUN
admet-376	320	25	to	to	ADP
admet-376	320	26	the	the	DET
admet-376	320	27	host	host	NOUN
admet-376	320	28	.	.	PUNCT
admet-376	321	1	when	when	SCONJ
admet-376	321	2	we	we	PRON
admet-376	321	3	include	include	VERB
admet-376	321	4	such	such	ADJ
admet-376	321	5	natural	natural	ADJ
admet-376	321	6	products	product	NOUN
admet-376	321	7	,	,	PUNCT
admet-376	321	8	we	we	PRON
admet-376	321	9	find	find	VERB
admet-376	321	10	that	that	SCONJ
admet-376	321	11	the	the	DET
admet-376	321	12	closeness	closeness	NOUN
admet-376	321	13	of	of	ADP
admet-376	321	14	at	at	ADV
admet-376	321	15	least	least	ADJ
admet-376	321	16	one	one	NUM
admet-376	321	17	of	of	ADP
admet-376	321	18	them	they	PRON
admet-376	321	19	,	,	PUNCT
admet-376	321	20	using	use	VERB
admet-376	321	21	one	one	NUM
admet-376	321	22	or	or	CCONJ
admet-376	321	23	more	more	ADJ
admet-376	321	24	encodings	encoding	NOUN
admet-376	321	25	,	,	PUNCT
admet-376	321	26	to	to	PART
admet-376	321	27	marketed	market	VERB
admet-376	321	28	drugs	drug	NOUN
admet-376	321	29	is	be	AUX
admet-376	321	30	increased	increase	VERB
admet-376	321	31	massively	massively	ADV
admet-376	321	32	.	.	PUNCT
admet-376	322	1	this	this	PRON
admet-376	322	2	at	at	ADP
admet-376	322	3	once	once	ADV
admet-376	322	4	hereby	hereby	ADV
admet-376	322	5	points	point	VERB
admet-376	322	6	us	we	PRON
admet-376	322	7	at	at	ADP
admet-376	322	8	substances	substance	NOUN
admet-376	322	9	that	that	PRON
admet-376	322	10	might	might	AUX
admet-376	322	11	be	be	AUX
admet-376	322	12	the	the	DET
admet-376	322	13	‘	'	PUNCT
admet-376	322	14	natural	natural	ADJ
admet-376	322	15	’	'	PUNCT
admet-376	322	16	substrates	substrate	NOUN
admet-376	322	17	of	of	ADP
admet-376	322	18	a	a	DET
admet-376	322	19	given	give	VERB
admet-376	322	20	drug	drug	NOUN
admet-376	322	21	transporter	transporter	NOUN
admet-376	322	22	,	,	PUNCT
admet-376	322	23	suggests	suggest	VERB
admet-376	322	24	molecules	molecule	NOUN
admet-376	322	25	for	for	ADP
admet-376	322	26	qsar	qsar	NOUN
admet-376	322	27	studies	study	NOUN
admet-376	322	28	thereon	thereon	NOUN
admet-376	322	29	,	,	PUNCT
admet-376	322	30	and	and	CCONJ
admet-376	322	31	o'hagan	o'hagan	PROPN
admet-376	322	32	&	&	CCONJ
admet-376	322	33	kell	kell	PROPN
admet-376	322	34	admet	admet	PROPN
admet-376	322	35	&	&	CCONJ
admet-376	322	36	dmpk	dmpk	PROPN
admet-376	322	37	5(2	5(2	NUM
admet-376	322	38	)	)	PUNCT
admet-376	322	39	(	(	PUNCT
admet-376	322	40	2017	2017	NUM
admet-376	322	41	)	)	PUNCT
admet-376	322	42	85	85	NUM
admet-376	322	43	-	-	SYM
admet-376	322	44	125	125	NUM
admet-376	322	45	114	114	NUM
admet-376	322	46	potentially	potentially	ADV
admet-376	322	47	provides	provide	VERB
admet-376	322	48	novel	novel	ADJ
admet-376	322	49	scaffolds	scaffold	NOUN
admet-376	322	50	for	for	ADP
admet-376	322	51	pharmaceutical	pharmaceutical	ADJ
admet-376	322	52	drug	drug	NOUN
admet-376	322	53	discovery	discovery	NOUN
admet-376	322	54	.	.	PUNCT
admet-376	323	1	acknowledgements	acknowledgement	NOUN
admet-376	323	2	:	:	PUNCT
admet-376	323	3	we	we	PRON
admet-376	323	4	thank	thank	VERB
admet-376	323	5	the	the	DET
admet-376	323	6	bbsrc	bbsrc	NOUN
admet-376	323	7	for	for	ADP
admet-376	323	8	financial	financial	ADJ
admet-376	323	9	support	support	NOUN
admet-376	323	10	(	(	PUNCT
admet-376	323	11	grants	grant	NOUN
admet-376	323	12	bb	bb	NOUN
admet-376	323	13	/	/	SYM
admet-376	323	14	k019783/1	k019783/1	NOUN
admet-376	323	15	,	,	PUNCT
admet-376	323	16	bb	bb	NOUN
admet-376	323	17	/	/	SYM
admet-376	323	18	p009042/1	p009042/1	NOUN
admet-376	323	19	and	and	CCONJ
admet-376	323	20	bb	bb	NOUN
admet-376	323	21	/	/	SYM
admet-376	323	22	m017702/1	m017702/1	NOUN
admet-376	323	23	)	)	PUNCT
admet-376	323	24	,	,	PUNCT
admet-376	323	25	and	and	CCONJ
admet-376	323	26	professor	professor	PROPN
admet-376	323	27	david	david	PROPN
admet-376	323	28	wishart	wishart	PROPN
admet-376	323	29	and	and	CCONJ
admet-376	323	30	colleagues	colleague	NOUN
admet-376	323	31	for	for	ADP
admet-376	323	32	providing	provide	VERB
admet-376	323	33	their	their	PRON
admet-376	323	34	serum	serum	NOUN
admet-376	323	35	metabolome	metabolome	PROPN
admet-376	323	36	database	database	NOUN
admet-376	323	37	in	in	ADP
admet-376	323	38	a	a	DET
admet-376	323	39	particularly	particularly	ADV
admet-376	323	40	convenient	convenient	ADJ
admet-376	323	41	format	format	NOUN
admet-376	323	42	.	.	PUNCT
admet-376	324	1	references	reference	NOUN
admet-376	324	2	[	[	X
admet-376	324	3	1	1	NUM
admet-376	324	4	]	]	X
admet-376	324	5	p.d	p.d	PROPN
admet-376	324	6	.	.	PROPN
admet-376	324	7	dobson	dobson	PROPN
admet-376	324	8	,	,	PUNCT
admet-376	324	9	d.b	d.b	PROPN
admet-376	324	10	.	.	PROPN
admet-376	324	11	kell	kell	PROPN
admet-376	324	12	.	.	PUNCT
admet-376	325	1	carrier	carrier	NOUN
admet-376	325	2	-	-	PUNCT
admet-376	325	3	mediated	mediate	VERB
admet-376	325	4	cellular	cellular	ADJ
admet-376	325	5	uptake	uptake	NOUN
admet-376	325	6	of	of	ADP
admet-376	325	7	pharmaceutical	pharmaceutical	ADJ
admet-376	325	8	drugs	drug	NOUN
admet-376	325	9	:	:	PUNCT
admet-376	325	10	an	an	DET
admet-376	325	11	exception	exception	NOUN
admet-376	325	12	or	or	CCONJ
admet-376	325	13	the	the	DET
admet-376	325	14	rule	rule	NOUN
admet-376	325	15	?	?	PUNCT
admet-376	326	1	,	,	PUNCT
admet-376	326	2	nat	nat	PROPN
admet-376	326	3	rev	rev	VERB
admet-376	326	4	drug	drug	NOUN
admet-376	326	5	disc	disc	VERB
admet-376	326	6	7	7	NUM
admet-376	326	7	(	(	PUNCT
admet-376	326	8	2008	2008	NUM
admet-376	326	9	)	)	PUNCT
admet-376	326	10	205	205	NUM
admet-376	326	11	-	-	SYM
admet-376	326	12	220	220	NUM
admet-376	326	13	.	.	PUNCT
admet-376	327	1	[	[	X
admet-376	327	2	2	2	NUM
admet-376	327	3	]	]	X
admet-376	327	4	p.d	p.d	PROPN
admet-376	327	5	.	.	PROPN
admet-376	327	6	dobson	dobson	PROPN
admet-376	327	7	,	,	PUNCT
admet-376	327	8	y.	y.	PROPN
admet-376	327	9	patel	patel	PROPN
admet-376	327	10	,	,	PUNCT
admet-376	327	11	d.b	d.b	PROPN
admet-376	327	12	.	.	PROPN
admet-376	327	13	kell	kell	PROPN
admet-376	327	14	.	.	PUNCT
admet-376	328	1	"	"	PUNCT
admet-376	328	2	metabolite	metabolite	NOUN
admet-376	328	3	-	-	PUNCT
admet-376	328	4	likeness	likeness	NOUN
admet-376	328	5	"	"	PUNCT
admet-376	328	6	as	as	ADP
admet-376	328	7	a	a	DET
admet-376	328	8	criterion	criterion	NOUN
admet-376	328	9	in	in	ADP
admet-376	328	10	the	the	DET
admet-376	328	11	design	design	NOUN
admet-376	328	12	and	and	CCONJ
admet-376	328	13	selection	selection	NOUN
admet-376	328	14	of	of	ADP
admet-376	328	15	pharmaceutical	pharmaceutical	ADJ
admet-376	328	16	drug	drug	NOUN
admet-376	328	17	libraries	library	NOUN
admet-376	328	18	,	,	PUNCT
admet-376	328	19	drug	drug	NOUN
admet-376	328	20	disc	disc	NOUN
admet-376	328	21	today	today	NOUN
admet-376	328	22	14	14	NUM
admet-376	328	23	(	(	PUNCT
admet-376	328	24	2009	2009	NUM
admet-376	328	25	)	)	PUNCT
admet-376	328	26	31	31	NUM
admet-376	328	27	-	-	SYM
admet-376	328	28	40	40	NUM
admet-376	328	29	.	.	PUNCT
admet-376	329	1	[	[	X
admet-376	329	2	3	3	X
admet-376	329	3	]	]	X
admet-376	329	4	p.	p.	PROPN
admet-376	329	5	dobson	dobson	PROPN
admet-376	329	6	,	,	PUNCT
admet-376	329	7	k.	k.	PROPN
admet-376	329	8	lanthaler	lanthaler	PROPN
admet-376	329	9	,	,	PUNCT
admet-376	329	10	s.g	s.g	PROPN
admet-376	329	11	.	.	PROPN
admet-376	329	12	oliver	oliver	PROPN
admet-376	329	13	,	,	PUNCT
admet-376	329	14	d.b	d.b	PROPN
admet-376	329	15	.	.	PROPN
admet-376	329	16	kell	kell	PROPN
admet-376	329	17	.	.	PUNCT
admet-376	330	1	implications	implication	NOUN
admet-376	330	2	of	of	ADP
admet-376	330	3	the	the	DET
admet-376	330	4	dominant	dominant	ADJ
admet-376	330	5	role	role	NOUN
admet-376	330	6	of	of	ADP
admet-376	330	7	cellular	cellular	ADJ
admet-376	330	8	transporters	transporter	NOUN
admet-376	330	9	in	in	ADP
admet-376	330	10	drug	drug	NOUN
admet-376	330	11	uptake	uptake	NOUN
admet-376	330	12	,	,	PUNCT
admet-376	330	13	curr	curr	PROPN
admet-376	330	14	top	top	ADJ
admet-376	330	15	med	med	ADJ
admet-376	330	16	chem	chem	NOUN
admet-376	330	17	9	9	NUM
admet-376	330	18	(	(	PUNCT
admet-376	330	19	2009	2009	NUM
admet-376	330	20	)	)	PUNCT
admet-376	330	21	163	163	NUM
admet-376	330	22	-	-	SYM
admet-376	330	23	184	184	NUM
admet-376	330	24	.	.	PUNCT
admet-376	331	1	[	[	X
admet-376	331	2	4	4	NUM
admet-376	331	3	]	]	X
admet-376	331	4	k.m	k.m	PROPN
admet-376	331	5	.	.	PROPN
admet-376	331	6	giacomini	giacomini	PROPN
admet-376	331	7	,	,	PUNCT
admet-376	331	8	s.m	s.m	PROPN
admet-376	331	9	.	.	PROPN
admet-376	331	10	huang	huang	PROPN
admet-376	331	11	,	,	PUNCT
admet-376	331	12	d.j	d.j	PROPN
admet-376	331	13	.	.	PROPN
admet-376	331	14	tweedie	tweedie	PROPN
admet-376	331	15	,	,	PUNCT
admet-376	331	16	l.z	l.z	PROPN
admet-376	331	17	.	.	PROPN
admet-376	331	18	benet	benet	PROPN
admet-376	331	19	,	,	PUNCT
admet-376	331	20	k.l	k.l	PROPN
admet-376	331	21	.	.	PROPN
admet-376	331	22	brouwer	brouwer	PROPN
admet-376	331	23	,	,	PUNCT
admet-376	331	24	x.	x.	PROPN
admet-376	331	25	chu	chu	PROPN
admet-376	331	26	,	,	PUNCT
admet-376	331	27	a.	a.	PROPN
admet-376	331	28	dahlin	dahlin	PROPN
admet-376	331	29	,	,	PUNCT
admet-376	331	30	r.	r.	PROPN
admet-376	331	31	evers	evers	PROPN
admet-376	331	32	,	,	PUNCT
admet-376	331	33	v.	v.	CCONJ
admet-376	331	34	fischer	fischer	PROPN
admet-376	331	35	,	,	PUNCT
admet-376	331	36	k.m	k.m	PROPN
admet-376	331	37	.	.	PROPN
admet-376	331	38	hillgren	hillgren	PROPN
admet-376	331	39	,	,	PUNCT
admet-376	331	40	k.a	k.a	PROPN
admet-376	331	41	.	.	PROPN
admet-376	331	42	hoffmaster	hoffmaster	PROPN
admet-376	331	43	,	,	PUNCT
admet-376	331	44	t.	t.	PROPN
admet-376	331	45	ishikawa	ishikawa	PROPN
admet-376	331	46	,	,	PUNCT
admet-376	331	47	d.	d.	PROPN
admet-376	331	48	keppler	keppler	PROPN
admet-376	331	49	,	,	PUNCT
admet-376	331	50	r.b	r.b	PROPN
admet-376	331	51	.	.	PROPN
admet-376	331	52	kim	kim	PROPN
admet-376	331	53	,	,	PUNCT
admet-376	331	54	c.a	c.a	PROPN
admet-376	331	55	.	.	PROPN
admet-376	331	56	lee	lee	PROPN
admet-376	331	57	,	,	PUNCT
admet-376	331	58	m.	m.	PROPN
admet-376	331	59	niemi	niemi	PROPN
admet-376	331	60	,	,	PUNCT
admet-376	331	61	j.w	j.w	PROPN
admet-376	331	62	.	.	PROPN
admet-376	331	63	polli	polli	PROPN
admet-376	331	64	,	,	PUNCT
admet-376	331	65	y.	y.	PROPN
admet-376	331	66	sugiyama	sugiyama	PROPN
admet-376	331	67	,	,	PUNCT
admet-376	331	68	p.w	p.w	PROPN
admet-376	331	69	.	.	PROPN
admet-376	331	70	swaan	swaan	PROPN
admet-376	331	71	,	,	PUNCT
admet-376	331	72	j.a	j.a	PROPN
admet-376	331	73	.	.	PROPN
admet-376	331	74	ware	ware	PROPN
admet-376	331	75	,	,	PUNCT
admet-376	331	76	s.h	s.h	PROPN
admet-376	331	77	.	.	PROPN
admet-376	331	78	wright	wright	PROPN
admet-376	331	79	,	,	PUNCT
admet-376	331	80	s.	s.	PROPN
admet-376	331	81	wah	wah	PROPN
admet-376	331	82	yee	yee	PROPN
admet-376	331	83	,	,	PUNCT
admet-376	331	84	m.j	m.j	PROPN
admet-376	331	85	.	.	PROPN
admet-376	331	86	zamek	zamek	PROPN
admet-376	331	87	-	-	PUNCT
admet-376	331	88	gliszczynski	gliszczynski	PROPN
admet-376	331	89	,	,	PUNCT
admet-376	331	90	l.	l.	PROPN
admet-376	331	91	zhang	zhang	PROPN
admet-376	331	92	.	.	PUNCT
admet-376	332	1	membrane	membrane	NOUN
admet-376	332	2	transporters	transporter	NOUN
admet-376	332	3	in	in	ADP
admet-376	332	4	drug	drug	NOUN
admet-376	332	5	development	development	NOUN
admet-376	333	1	,	,	PUNCT
admet-376	333	2	nat	nat	PROPN
admet-376	333	3	rev	rev	VERB
admet-376	333	4	drug	drug	PROPN
admet-376	333	5	discov	discov	PROPN
admet-376	333	6	9	9	NUM
admet-376	333	7	(	(	PUNCT
admet-376	333	8	2010	2010	NUM
admet-376	333	9	)	)	PUNCT
admet-376	333	10	215	215	NUM
admet-376	333	11	-	-	SYM
admet-376	333	12	236	236	NUM
admet-376	333	13	.	.	PUNCT
admet-376	334	1	[	[	X
admet-376	334	2	5	5	NUM
admet-376	334	3	]	]	SYM
admet-376	334	4	d.b	d.b	PROPN
admet-376	334	5	.	.	PROPN
admet-376	334	6	kell	kell	PROPN
admet-376	334	7	,	,	PUNCT
admet-376	334	8	p.d	p.d	PROPN
admet-376	334	9	.	.	PROPN
admet-376	334	10	dobson	dobson	PROPN
admet-376	334	11	,	,	PUNCT
admet-376	334	12	s.g	s.g	PROPN
admet-376	334	13	.	.	PROPN
admet-376	334	14	oliver	oliver	PROPN
admet-376	334	15	.	.	PUNCT
admet-376	334	16	pharmaceutical	pharmaceutical	PROPN
admet-376	334	17	drug	drug	NOUN
admet-376	334	18	transport	transport	NOUN
admet-376	334	19	:	:	PUNCT
admet-376	334	20	the	the	DET
admet-376	334	21	issues	issue	NOUN
admet-376	334	22	and	and	CCONJ
admet-376	334	23	the	the	DET
admet-376	334	24	implications	implication	NOUN
admet-376	334	25	that	that	SCONJ
admet-376	334	26	it	it	PRON
admet-376	334	27	is	be	AUX
admet-376	334	28	essentially	essentially	ADV
admet-376	334	29	carrier	carrier	NOUN
admet-376	334	30	-	-	PUNCT
admet-376	334	31	mediated	mediate	VERB
admet-376	334	32	only	only	ADV
admet-376	334	33	.	.	PUNCT
admet-376	334	34	,	,	PUNCT
admet-376	334	35	drug	drug	NOUN
admet-376	334	36	disc	disc	NOUN
admet-376	334	37	today	today	NOUN
admet-376	334	38	16	16	NUM
admet-376	334	39	(	(	PUNCT
admet-376	334	40	2011	2011	NUM
admet-376	334	41	)	)	PUNCT
admet-376	334	42	704	704	NUM
admet-376	334	43	-	-	SYM
admet-376	334	44	714	714	NUM
admet-376	334	45	.	.	PUNCT
admet-376	335	1	[	[	X
admet-376	335	2	6	6	NUM
admet-376	335	3	]	]	SYM
admet-376	335	4	d.b	d.b	PROPN
admet-376	335	5	.	.	PROPN
admet-376	335	6	kell	kell	PROPN
admet-376	335	7	,	,	PUNCT
admet-376	335	8	p.d	p.d	PROPN
admet-376	335	9	.	.	PROPN
admet-376	335	10	dobson	dobson	PROPN
admet-376	335	11	,	,	PUNCT
admet-376	335	12	e.	e.	PROPN
admet-376	335	13	bilsland	bilsland	PROPN
admet-376	335	14	,	,	PUNCT
admet-376	335	15	s.g	s.g	PROPN
admet-376	335	16	.	.	PROPN
admet-376	335	17	oliver	oliver	PROPN
admet-376	335	18	.	.	PUNCT
admet-376	336	1	the	the	DET
admet-376	336	2	promiscuous	promiscuous	ADJ
admet-376	336	3	binding	binding	NOUN
admet-376	336	4	of	of	ADP
admet-376	336	5	pharmaceutical	pharmaceutical	ADJ
admet-376	336	6	drugs	drug	NOUN
admet-376	336	7	and	and	CCONJ
admet-376	336	8	their	their	PRON
admet-376	336	9	transporter	transporter	NOUN
admet-376	336	10	-	-	PUNCT
admet-376	336	11	mediated	mediate	VERB
admet-376	336	12	uptake	uptake	NOUN
admet-376	336	13	into	into	ADP
admet-376	336	14	cells	cell	NOUN
admet-376	336	15	:	:	PUNCT
admet-376	336	16	what	what	PRON
admet-376	336	17	we	we	PRON
admet-376	336	18	(	(	PUNCT
admet-376	336	19	need	need	VERB
admet-376	336	20	to	to	PART
admet-376	336	21	)	)	PUNCT
admet-376	336	22	know	know	VERB
admet-376	336	23	and	and	CCONJ
admet-376	336	24	how	how	SCONJ
admet-376	336	25	we	we	PRON
admet-376	336	26	can	can	AUX
admet-376	336	27	do	do	VERB
admet-376	336	28	so	so	ADV
admet-376	336	29	,	,	PUNCT
admet-376	336	30	drug	drug	NOUN
admet-376	336	31	disc	disc	NOUN
admet-376	336	32	today	today	NOUN
admet-376	336	33	18	18	NUM
admet-376	336	34	(	(	PUNCT
admet-376	336	35	2013	2013	NUM
admet-376	336	36	)	)	PUNCT
admet-376	336	37	218	218	NUM
admet-376	336	38	-	-	SYM
admet-376	336	39	239	239	NUM
admet-376	336	40	.	.	PUNCT
admet-376	337	1	[	[	X
admet-376	337	2	7	7	NUM
admet-376	337	3	]	]	X
admet-376	337	4	d.b	d.b	PROPN
admet-376	337	5	.	.	PROPN
admet-376	337	6	kell	kell	PROPN
admet-376	337	7	.	.	PUNCT
admet-376	338	1	finding	find	VERB
admet-376	338	2	novel	novel	ADJ
admet-376	338	3	pharmaceuticals	pharmaceutical	NOUN
admet-376	338	4	in	in	ADP
admet-376	338	5	the	the	DET
admet-376	338	6	systems	system	NOUN
admet-376	338	7	biology	biology	NOUN
admet-376	338	8	era	era	NOUN
admet-376	338	9	using	use	VERB
admet-376	338	10	multiple	multiple	ADJ
admet-376	338	11	effective	effective	ADJ
admet-376	338	12	drug	drug	NOUN
admet-376	338	13	targets	target	NOUN
admet-376	338	14	,	,	PUNCT
admet-376	338	15	phenotypic	phenotypic	ADJ
admet-376	338	16	screening	screening	NOUN
admet-376	338	17	,	,	PUNCT
admet-376	338	18	and	and	CCONJ
admet-376	338	19	knowledge	knowledge	NOUN
admet-376	338	20	of	of	ADP
admet-376	338	21	transporters	transporter	NOUN
admet-376	338	22	:	:	PUNCT
admet-376	338	23	where	where	SCONJ
admet-376	338	24	drug	drug	NOUN
admet-376	338	25	discovery	discovery	NOUN
admet-376	338	26	went	go	VERB
admet-376	338	27	wrong	wrong	ADJ
admet-376	338	28	and	and	CCONJ
admet-376	338	29	how	how	SCONJ
admet-376	338	30	to	to	PART
admet-376	338	31	fix	fix	VERB
admet-376	338	32	it	it	PRON
admet-376	338	33	,	,	PUNCT
admet-376	338	34	febs	febs	VERB
admet-376	338	35	j	j	PROPN
admet-376	338	36	280	280	NUM
admet-376	338	37	(	(	PUNCT
admet-376	338	38	2013	2013	NUM
admet-376	338	39	)	)	PUNCT
admet-376	338	40	5957	5957	NUM
admet-376	338	41	-	-	SYM
admet-376	338	42	5980	5980	NUM
admet-376	338	43	.	.	PUNCT
admet-376	339	1	[	[	X
admet-376	339	2	8	8	NUM
admet-376	339	3	]	]	X
admet-376	339	4	y.	y.	PROPN
admet-376	339	5	sugiyama	sugiyama	PROPN
admet-376	339	6	,	,	PUNCT
admet-376	339	7	b.	b.	PROPN
admet-376	339	8	steffansen	steffansen	PROPN
admet-376	339	9	,	,	PUNCT
admet-376	339	10	transporters	transporter	NOUN
admet-376	339	11	in	in	ADP
admet-376	339	12	drug	drug	NOUN
admet-376	339	13	development	development	NOUN
admet-376	339	14	:	:	PUNCT
admet-376	339	15	discovery	discovery	NOUN
admet-376	339	16	,	,	PUNCT
admet-376	339	17	optimization	optimization	NOUN
admet-376	339	18	,	,	PUNCT
admet-376	339	19	clinical	clinical	ADJ
admet-376	339	20	study	study	NOUN
admet-376	339	21	and	and	CCONJ
admet-376	339	22	regulation	regulation	NOUN
admet-376	339	23	,	,	PUNCT
admet-376	339	24	aaps	aap	NOUN
admet-376	339	25	/	/	SYM
admet-376	339	26	springer	springer	NOUN
admet-376	339	27	,	,	PUNCT
admet-376	339	28	new	new	PROPN
admet-376	339	29	york	york	PROPN
admet-376	339	30	,	,	PUNCT
admet-376	339	31	2013	2013	NUM
admet-376	339	32	.	.	PUNCT
admet-376	340	1	[	[	X
admet-376	340	2	9	9	NUM
admet-376	340	3	]	]	SYM
admet-376	340	4	d.b	d.b	PROPN
admet-376	340	5	.	.	PROPN
admet-376	340	6	kell	kell	PROPN
admet-376	340	7	,	,	PUNCT
admet-376	340	8	r.	r.	PROPN
admet-376	340	9	goodacre	goodacre	PROPN
admet-376	340	10	.	.	PUNCT
admet-376	341	1	metabolomics	metabolomic	NOUN
admet-376	341	2	and	and	CCONJ
admet-376	341	3	systems	system	NOUN
admet-376	341	4	pharmacology	pharmacology	NOUN
admet-376	341	5	:	:	PUNCT
admet-376	341	6	why	why	SCONJ
admet-376	341	7	and	and	CCONJ
admet-376	341	8	how	how	SCONJ
admet-376	341	9	to	to	PART
admet-376	341	10	model	model	VERB
admet-376	341	11	the	the	DET
admet-376	341	12	human	human	PROPN
admet-376	341	13	metabolic	metabolic	NOUN
admet-376	341	14	network	network	NOUN
admet-376	341	15	for	for	ADP
admet-376	341	16	drug	drug	NOUN
admet-376	341	17	discovery	discovery	NOUN
admet-376	341	18	,	,	PUNCT
admet-376	341	19	drug	drug	NOUN
admet-376	341	20	disc	disc	NOUN
admet-376	341	21	today	today	NOUN
admet-376	341	22	19	19	NUM
admet-376	341	23	(	(	PUNCT
admet-376	341	24	2014	2014	NUM
admet-376	341	25	)	)	PUNCT
admet-376	341	26	171	171	NUM
admet-376	341	27	-	-	SYM
admet-376	341	28	182	182	NUM
admet-376	341	29	.	.	PUNCT
admet-376	342	1	[	[	X
admet-376	342	2	10	10	NUM
admet-376	342	3	]	]	X
admet-376	342	4	d.b	d.b	PROPN
admet-376	342	5	.	.	PROPN
admet-376	342	6	kell	kell	PROPN
admet-376	342	7	,	,	PUNCT
admet-376	342	8	s.g	s.g	PROPN
admet-376	342	9	.	.	PROPN
admet-376	342	10	oliver	oliver	PROPN
admet-376	342	11	.	.	PUNCT
admet-376	343	1	how	how	SCONJ
admet-376	343	2	drugs	drug	NOUN
admet-376	343	3	get	get	VERB
admet-376	343	4	into	into	ADP
admet-376	343	5	cells	cell	NOUN
admet-376	343	6	:	:	PUNCT
admet-376	343	7	tested	test	VERB
admet-376	343	8	and	and	CCONJ
admet-376	343	9	testable	testable	ADJ
admet-376	343	10	predictions	prediction	NOUN
admet-376	343	11	to	to	PART
admet-376	343	12	help	help	VERB
admet-376	343	13	discriminate	discriminate	VERB
admet-376	343	14	between	between	ADP
admet-376	343	15	transporter	transporter	NOUN
admet-376	343	16	-	-	PUNCT
admet-376	343	17	mediated	mediate	VERB
admet-376	343	18	uptake	uptake	NOUN
admet-376	343	19	and	and	CCONJ
admet-376	343	20	lipoidal	lipoidal	ADJ
admet-376	343	21	bilayer	bilayer	NOUN
admet-376	343	22	diffusion	diffusion	NOUN
admet-376	343	23	,	,	PUNCT
admet-376	343	24	front	front	ADJ
admet-376	343	25	pharmacol	pharmacol	NOUN
admet-376	343	26	5	5	NUM
admet-376	343	27	(	(	PUNCT
admet-376	343	28	2014	2014	NUM
admet-376	343	29	)	)	PUNCT
admet-376	343	30	231	231	NUM
admet-376	343	31	.	.	PUNCT
admet-376	344	1	[	[	X
admet-376	344	2	11	11	NUM
admet-376	344	3	]	]	X
admet-376	344	4	g.e	g.e	PROPN
admet-376	344	5	.	.	PROPN
admet-376	344	6	winter	winter	PROPN
admet-376	344	7	,	,	PUNCT
admet-376	344	8	b.	b.	PROPN
admet-376	344	9	radic	radic	PROPN
admet-376	344	10	,	,	PUNCT
admet-376	344	11	c.	c.	PROPN
admet-376	344	12	mayor	mayor	PROPN
admet-376	344	13	-	-	PUNCT
admet-376	344	14	ruiz	ruiz	NOUN
admet-376	344	15	,	,	PUNCT
admet-376	344	16	v.a	v.a	PROPN
admet-376	344	17	.	.	PROPN
admet-376	344	18	blomen	blomen	PROPN
admet-376	344	19	,	,	PUNCT
admet-376	344	20	c.	c.	PROPN
admet-376	344	21	trefzer	trefzer	NOUN
admet-376	344	22	,	,	PUNCT
admet-376	344	23	r.k	r.k	PROPN
admet-376	344	24	.	.	PROPN
admet-376	344	25	kandasamy	kandasamy	PROPN
admet-376	344	26	,	,	PUNCT
admet-376	344	27	k.v.m	k.v.m	NOUN
admet-376	344	28	.	.	PUNCT
admet-376	345	1	huber	huber	PROPN
admet-376	345	2	,	,	PUNCT
admet-376	345	3	m.	m.	NOUN
admet-376	345	4	gridling	gridling	NOUN
admet-376	345	5	,	,	PUNCT
admet-376	345	6	d.	d.	PROPN
admet-376	345	7	chen	chen	PROPN
admet-376	345	8	,	,	PUNCT
admet-376	345	9	t.	t.	PROPN
admet-376	345	10	klampfl	klampfl	PROPN
admet-376	345	11	,	,	PUNCT
admet-376	345	12	r.	r.	PROPN
admet-376	345	13	kralovics	kralovics	PROPN
admet-376	345	14	,	,	PUNCT
admet-376	345	15	s.	s.	PROPN
admet-376	345	16	kubicek	kubicek	PROPN
admet-376	345	17	,	,	PUNCT
admet-376	345	18	o.	o.	PROPN
admet-376	345	19	fernandez	fernandez	PROPN
admet-376	345	20	-	-	PUNCT
admet-376	345	21	capetillo	capetillo	PROPN
admet-376	345	22	,	,	PUNCT
admet-376	345	23	t.r	t.r	PROPN
admet-376	345	24	.	.	PROPN
admet-376	345	25	brummelkamp	brummelkamp	PROPN
admet-376	345	26	,	,	PUNCT
admet-376	345	27	g.	g.	PROPN
admet-376	345	28	superti	superti	PROPN
admet-376	345	29	-	-	PUNCT
admet-376	345	30	furga	furga	NOUN
admet-376	345	31	.	.	PUNCT
admet-376	346	1	the	the	DET
admet-376	346	2	solute	solute	ADJ
admet-376	346	3	carrier	carrier	NOUN
admet-376	346	4	slc35f2	slc35f2	VERB
admet-376	346	5	enables	enable	VERB
admet-376	346	6	ym155	ym155	NOUN
admet-376	346	7	-	-	PUNCT
admet-376	346	8	mediated	mediate	VERB
admet-376	346	9	dna	dna	NOUN
admet-376	346	10	damage	damage	NOUN
admet-376	346	11	toxicity	toxicity	NOUN
admet-376	346	12	,	,	PUNCT
admet-376	346	13	nat	nat	PROPN
admet-376	346	14	chem	chem	NOUN
admet-376	346	15	biol	biol	NOUN
admet-376	346	16	10	10	NUM
admet-376	346	17	(	(	PUNCT
admet-376	346	18	2014	2014	NUM
admet-376	346	19	)	)	PUNCT
admet-376	346	20	768	768	NUM
admet-376	346	21	-	-	SYM
admet-376	346	22	773	773	NUM
admet-376	346	23	.	.	PUNCT
admet-376	347	1	[	[	X
admet-376	347	2	12	12	NUM
admet-376	347	3	]	]	PUNCT
admet-376	347	4	a.	a.	NOUN
admet-376	347	5	césar	césar	PROPN
admet-376	347	6	-	-	PUNCT
admet-376	347	7	razquin	razquin	PROPN
admet-376	347	8	,	,	PUNCT
admet-376	347	9	b.	b.	PROPN
admet-376	347	10	snijder	snijder	PROPN
admet-376	347	11	,	,	PUNCT
admet-376	347	12	t.	t.	PROPN
admet-376	347	13	frappier	frappier	PROPN
admet-376	347	14	-	-	PUNCT
admet-376	347	15	brinton	brinton	PROPN
admet-376	347	16	,	,	PUNCT
admet-376	347	17	r.	r.	PROPN
admet-376	347	18	isserlin	isserlin	PROPN
admet-376	347	19	,	,	PUNCT
admet-376	347	20	g.	g.	PROPN
admet-376	347	21	gyimesi	gyimesi	PROPN
admet-376	347	22	,	,	PUNCT
admet-376	347	23	x.	x.	PROPN
admet-376	347	24	bai	bai	PROPN
admet-376	347	25	,	,	PUNCT
admet-376	347	26	r.a	r.a	PROPN
admet-376	347	27	.	.	PROPN
admet-376	347	28	reithmeier	reithmeier	PROPN
admet-376	347	29	,	,	PUNCT
admet-376	347	30	d.	d.	PROPN
admet-376	347	31	hepworth	hepworth	PROPN
admet-376	347	32	,	,	PUNCT
admet-376	347	33	m.a	m.a	PROPN
admet-376	347	34	.	.	PROPN
admet-376	347	35	hediger	hediger	PROPN
admet-376	347	36	,	,	PUNCT
admet-376	347	37	a.m.	a.m.	PROPN
admet-376	347	38	edwards	edwards	PROPN
admet-376	347	39	,	,	PUNCT
admet-376	347	40	g.	g.	PROPN
admet-376	347	41	superti	superti	PROPN
admet-376	347	42	-	-	PUNCT
admet-376	347	43	furga	furga	NOUN
admet-376	347	44	.	.	PUNCT
admet-376	348	1	a	a	DET
admet-376	348	2	call	call	NOUN
admet-376	348	3	for	for	ADP
admet-376	348	4	systematic	systematic	ADJ
admet-376	348	5	research	research	NOUN
admet-376	348	6	on	on	ADP
admet-376	348	7	solute	solute	NOUN
admet-376	348	8	carriers	carrier	NOUN
admet-376	348	9	,	,	PUNCT
admet-376	348	10	cell	cell	NOUN
admet-376	348	11	162	162	NUM
admet-376	348	12	(	(	PUNCT
admet-376	348	13	2015	2015	NUM
admet-376	348	14	)	)	PUNCT
admet-376	348	15	478	478	NUM
admet-376	348	16	-	-	SYM
admet-376	348	17	487	487	NUM
admet-376	348	18	.	.	PUNCT
admet-376	349	1	[	[	X
admet-376	349	2	13	13	NUM
admet-376	349	3	]	]	SYM
admet-376	349	4	d.b	d.b	PROPN
admet-376	349	5	.	.	PROPN
admet-376	349	6	kell	kell	PROPN
admet-376	349	7	.	.	PUNCT
admet-376	350	1	what	what	PRON
admet-376	350	2	would	would	AUX
admet-376	350	3	be	be	AUX
admet-376	350	4	the	the	DET
admet-376	350	5	observable	observable	ADJ
admet-376	350	6	consequences	consequence	NOUN
admet-376	350	7	if	if	SCONJ
admet-376	350	8	phospholipid	phospholipid	NOUN
admet-376	350	9	bilayer	bilayer	NOUN
admet-376	350	10	diffusion	diffusion	NOUN
admet-376	350	11	of	of	ADP
admet-376	350	12	drugs	drug	NOUN
admet-376	350	13	into	into	ADP
admet-376	350	14	cells	cell	NOUN
admet-376	350	15	is	be	AUX
admet-376	350	16	negligible	negligible	ADJ
admet-376	350	17	?	?	PUNCT
admet-376	350	18	,	,	PUNCT
admet-376	350	19	trends	trend	NOUN
admet-376	350	20	pharmacol	pharmacol	VERB
admet-376	350	21	sci	sci	PROPN
admet-376	350	22	36	36	NUM
admet-376	350	23	(	(	PUNCT
admet-376	350	24	2015	2015	NUM
admet-376	350	25	)	)	PUNCT
admet-376	350	26	15	15	NUM
admet-376	350	27	-	-	SYM
admet-376	350	28	21	21	NUM
admet-376	350	29	.	.	PUNCT
admet-376	351	1	[	[	X
admet-376	351	2	14	14	NUM
admet-376	351	3	]	]	PUNCT
admet-376	351	4	p.	p.	NOUN
admet-376	351	5	mendes	mende	NOUN
admet-376	351	6	,	,	PUNCT
admet-376	351	7	s.g	s.g	PROPN
admet-376	351	8	.	.	PROPN
admet-376	351	9	oliver	oliver	PROPN
admet-376	351	10	,	,	PUNCT
admet-376	351	11	d.b	d.b	PROPN
admet-376	351	12	.	.	PROPN
admet-376	351	13	kell	kell	PROPN
admet-376	351	14	.	.	PUNCT
admet-376	352	1	fitting	fitting	ADJ
admet-376	352	2	transporter	transporter	NOUN
admet-376	352	3	activities	activity	NOUN
admet-376	352	4	to	to	ADP
admet-376	352	5	cellular	cellular	ADJ
admet-376	352	6	drug	drug	NOUN
admet-376	352	7	concentrations	concentration	NOUN
admet-376	352	8	and	and	CCONJ
admet-376	352	9	fluxes	flux	NOUN
admet-376	352	10	:	:	PUNCT
admet-376	352	11	why	why	SCONJ
admet-376	352	12	the	the	DET
admet-376	352	13	bumblebee	bumblebee	NOUN
admet-376	352	14	can	can	AUX
admet-376	352	15	fly	fly	VERB
admet-376	352	16	,	,	PUNCT
admet-376	352	17	trends	trend	NOUN
admet-376	352	18	pharmacol	pharmacol	PROPN
admet-376	352	19	sci	sci	PROPN
admet-376	352	20	36	36	NUM
admet-376	352	21	(	(	PUNCT
admet-376	352	22	2015	2015	NUM
admet-376	352	23	)	)	PUNCT
admet-376	352	24	710	710	NUM
admet-376	352	25	-	-	SYM
admet-376	352	26	723	723	NUM
admet-376	352	27	.	.	PUNCT
admet-376	353	1	[	[	X
admet-376	353	2	15	15	NUM
admet-376	353	3	]	]	X
admet-376	353	4	s.	s.	PROPN
admet-376	353	5	o'hagan	o'hagan	PROPN
admet-376	353	6	,	,	PUNCT
admet-376	353	7	d.b	d.b	PROPN
admet-376	353	8	.	.	PROPN
admet-376	353	9	kell	kell	PROPN
admet-376	353	10	.	.	PUNCT
admet-376	354	1	the	the	DET
admet-376	354	2	apparent	apparent	ADJ
admet-376	354	3	permeabilities	permeability	NOUN
admet-376	354	4	of	of	ADP
admet-376	354	5	caco-2	caco-2	NUM
admet-376	354	6	cells	cell	NOUN
admet-376	354	7	to	to	ADP
admet-376	354	8	marketed	market	VERB
admet-376	354	9	drugs	drug	NOUN
admet-376	354	10	:	:	PUNCT
admet-376	354	11	magnitude	magnitude	NOUN
admet-376	354	12	,	,	PUNCT
admet-376	354	13	and	and	CCONJ
admet-376	354	14	independence	independence	NOUN
admet-376	354	15	from	from	ADP
admet-376	354	16	both	both	DET
admet-376	354	17	biophysical	biophysical	ADJ
admet-376	354	18	properties	property	NOUN
admet-376	354	19	and	and	CCONJ
admet-376	354	20	endogenite	endogenite	NOUN
admet-376	354	21	similarities	similarity	NOUN
admet-376	354	22	peerj	peerj	VERB
admet-376	354	23	3	3	NUM
admet-376	354	24	(	(	PUNCT
admet-376	354	25	2015	2015	NUM
admet-376	354	26	)	)	PUNCT
admet-376	354	27	e1405	e1405	PROPN
admet-376	354	28	.	.	PUNCT
admet-376	355	1	[	[	X
admet-376	355	2	16	16	NUM
admet-376	355	3	]	]	X
admet-376	355	4	d.b	d.b	PROPN
admet-376	355	5	.	.	PROPN
admet-376	355	6	kell	kell	PROPN
admet-376	355	7	.	.	PUNCT
admet-376	356	1	implications	implication	NOUN
admet-376	356	2	of	of	ADP
admet-376	356	3	endogenous	endogenous	ADJ
admet-376	356	4	roles	role	NOUN
admet-376	356	5	of	of	ADP
admet-376	356	6	transporters	transporter	NOUN
admet-376	356	7	for	for	ADP
admet-376	356	8	drug	drug	NOUN
admet-376	356	9	discovery	discovery	NOUN
admet-376	356	10	:	:	PUNCT
admet-376	356	11	hitchhiking	hitchhike	VERB
admet-376	356	12	and	and	CCONJ
admet-376	356	13	metabolite	metabolite	NOUN
admet-376	356	14	-	-	PUNCT
admet-376	356	15	likeness	likeness	NOUN
admet-376	356	16	,	,	PUNCT
admet-376	356	17	nat	nat	PROPN
admet-376	356	18	rev	rev	PROPN
admet-376	356	19	drug	drug	NOUN
admet-376	356	20	disc	disc	VERB
admet-376	356	21	15	15	NUM
admet-376	356	22	(	(	PUNCT
admet-376	356	23	2016	2016	NUM
admet-376	356	24	)	)	PUNCT
admet-376	356	25	143	143	NUM
admet-376	356	26	-	-	SYM
admet-376	356	27	144	144	NUM
admet-376	356	28	.	.	PUNCT
admet-376	357	1	[	[	X
admet-376	357	2	17	17	NUM
admet-376	357	3	]	]	X
admet-376	357	4	d.b	d.b	PROPN
admet-376	357	5	.	.	PROPN
admet-376	357	6	kell	kell	PROPN
admet-376	357	7	.	.	PUNCT
admet-376	358	1	how	how	SCONJ
admet-376	358	2	drugs	drug	NOUN
admet-376	358	3	pass	pass	VERB
admet-376	358	4	through	through	ADP
admet-376	358	5	biological	biological	ADJ
admet-376	358	6	cell	cell	NOUN
admet-376	358	7	membranes	membrane	NOUN
admet-376	358	8	–	–	PUNCT
admet-376	358	9	a	a	DET
admet-376	358	10	paradigm	paradigm	NOUN
admet-376	358	11	shift	shift	NOUN
admet-376	358	12	in	in	ADP
admet-376	358	13	our	our	PRON
admet-376	358	14	understanding	understanding	NOUN
admet-376	358	15	?	?	PUNCT
admet-376	358	16	,	,	PUNCT
admet-376	358	17	beilstein	beilstein	PROPN
admet-376	358	18	magazine	magazine	NOUN
admet-376	358	19	2	2	NUM
admet-376	358	20	(	(	PUNCT
admet-376	358	21	2016	2016	NUM
admet-376	358	22	)	)	PUNCT
admet-376	358	23	http://www.beilsteininstitut.de/download/628/609_kell.pdf	http://www.beilsteininstitut.de/download/628/609_kell.pdf	NOUN
admet-376	358	24	.	.	PUNCT
admet-376	359	1	http://www.beilstein-institut.de/download/628/609_kell.pdf	http://www.beilstein-institut.de/download/628/609_kell.pdf	PROPN
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admet-376	359	3	admet	admet	PROPN
admet-376	359	4	&	&	CCONJ
admet-376	359	5	dmpk	dmpk	PROPN
admet-376	359	6	5(2	5(2	NUM
admet-376	359	7	)	)	PUNCT
admet-376	359	8	(	(	PUNCT
admet-376	359	9	2017	2017	NUM
admet-376	359	10	)	)	PUNCT
admet-376	359	11	85	85	NUM
admet-376	359	12	-	-	SYM
admet-376	359	13	125	125	NUM
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admet-376	359	15	natural	natural	ADJ
admet-376	359	16	products	product	NOUN
admet-376	359	17	as	as	ADP
admet-376	359	18	‘	'	PUNCT
admet-376	359	19	natural	natural	ADJ
admet-376	359	20	’	'	PUNCT
admet-376	359	21	drug	drug	NOUN
admet-376	359	22	transporter	transporter	NOUN
admet-376	359	23	substrates	substrate	VERB
admet-376	359	24	doi	doi	NOUN
admet-376	359	25	:	:	PUNCT
admet-376	359	26	10.5599	10.5599	NUM
admet-376	359	27	/	/	SYM
admet-376	359	28	admet.5.2.376	admet.5.2.376	PROPN
admet-376	359	29	115	115	NUM
admet-376	360	1	[	[	X
admet-376	360	2	18	18	NUM
admet-376	360	3	]	]	X
admet-376	360	4	m.g	m.g	PROPN
admet-376	360	5	.	.	PROPN
admet-376	360	6	mooij	mooij	PROPN
admet-376	360	7	,	,	PUNCT
admet-376	360	8	a.t	a.t	PROPN
admet-376	360	9	.	.	PROPN
admet-376	360	10	nies	ny	NOUN
admet-376	360	11	,	,	PUNCT
admet-376	360	12	c.a.j	c.a.j	NOUN
admet-376	360	13	.	.	PUNCT
admet-376	360	14	knibbe	knibbe	PROPN
admet-376	360	15	,	,	PUNCT
admet-376	360	16	e.	e.	PROPN
admet-376	360	17	schaeffeler	schaeffeler	PROPN
admet-376	360	18	,	,	PUNCT
admet-376	360	19	d.	d.	PROPN
admet-376	360	20	tibboel	tibboel	PROPN
admet-376	360	21	,	,	PUNCT
admet-376	360	22	m.	m.	NOUN
admet-376	360	23	schwab	schwab	PROPN
admet-376	360	24	,	,	PUNCT
admet-376	360	25	s.n	s.n	PROPN
admet-376	360	26	.	.	PROPN
admet-376	360	27	de	de	X
admet-376	360	28	wildt	wildt	PROPN
admet-376	360	29	.	.	PUNCT
admet-376	361	1	development	development	NOUN
admet-376	361	2	of	of	ADP
admet-376	361	3	human	human	ADJ
admet-376	361	4	membrane	membrane	NOUN
admet-376	361	5	transporters	transporter	NOUN
admet-376	361	6	:	:	PUNCT
admet-376	361	7	drug	drug	NOUN
admet-376	361	8	disposition	disposition	NOUN
admet-376	361	9	and	and	CCONJ
admet-376	361	10	pharmacogenetics	pharmacogenetic	NOUN
admet-376	361	11	,	,	PUNCT
admet-376	361	12	clin	clin	PROPN
admet-376	361	13	pharmacokinet	pharmacokinet	PROPN
admet-376	361	14	55	55	NUM
admet-376	361	15	(	(	PUNCT
admet-376	361	16	2016	2016	NUM
admet-376	361	17	)	)	PUNCT
admet-376	361	18	507	507	NUM
admet-376	361	19	-	-	SYM
admet-376	361	20	524	524	NUM
admet-376	361	21	.	.	PUNCT
admet-376	362	1	[	[	X
admet-376	362	2	19	19	NUM
admet-376	362	3	]	]	X
admet-376	362	4	r.	r.	PROPN
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admet-376	362	6	,	,	PUNCT
admet-376	362	7	a.	a.	NOUN
admet-376	362	8	sparreboom	sparreboom	NOUN
admet-376	362	9	.	.	PUNCT
admet-376	363	1	drug	drug	NOUN
admet-376	363	2	transporters	transporter	NOUN
admet-376	363	3	:	:	PUNCT
admet-376	363	4	advances	advance	NOUN
admet-376	363	5	and	and	CCONJ
admet-376	363	6	opportunities	opportunity	NOUN
admet-376	363	7	,	,	PUNCT
admet-376	363	8	clin	clin	PROPN
admet-376	363	9	pharmacol	pharmacol	PROPN
admet-376	363	10	ther	ther	ADV
admet-376	363	11	100	100	NUM
admet-376	363	12	(	(	PUNCT
admet-376	363	13	2016	2016	NUM
admet-376	363	14	)	)	PUNCT
admet-376	363	15	398	398	NUM
admet-376	363	16	-	-	SYM
admet-376	363	17	403	403	NUM
admet-376	363	18	.	.	PUNCT
admet-376	364	1	[	[	X
admet-376	364	2	20	20	NUM
admet-376	364	3	]	]	PUNCT
admet-376	364	4	j.	j.	PROPN
admet-376	364	5	grixti	grixti	PROPN
admet-376	364	6	,	,	PUNCT
admet-376	364	7	s.	s.	PROPN
admet-376	364	8	o'hagan	o'hagan	PROPN
admet-376	364	9	,	,	PUNCT
admet-376	364	10	p.j	p.j	PROPN
admet-376	364	11	.	.	PROPN
admet-376	364	12	day	day	PROPN
admet-376	364	13	,	,	PUNCT
admet-376	364	14	d.b	d.b	PROPN
admet-376	364	15	.	.	PROPN
admet-376	364	16	kell	kell	PROPN
admet-376	364	17	.	.	PUNCT
admet-376	365	1	enhancing	enhance	VERB
admet-376	365	2	drug	drug	NOUN
admet-376	365	3	efficacy	efficacy	NOUN
admet-376	365	4	and	and	CCONJ
admet-376	365	5	therapeutic	therapeutic	ADJ
admet-376	365	6	index	index	NOUN
admet-376	365	7	through	through	ADP
admet-376	365	8	cheminformatics	cheminformatic	NOUN
admet-376	365	9	-	-	PUNCT
admet-376	365	10	based	base	VERB
admet-376	365	11	selection	selection	NOUN
admet-376	365	12	of	of	ADP
admet-376	365	13	small	small	ADJ
admet-376	365	14	molecule	molecule	NOUN
admet-376	365	15	binary	binary	ADJ
admet-376	365	16	weapons	weapon	NOUN
admet-376	365	17	that	that	PRON
admet-376	365	18	improve	improve	VERB
admet-376	365	19	transportermediated	transportermediate	VERB
admet-376	365	20	targeting	target	VERB
admet-376	365	21	:	:	PUNCT
admet-376	365	22	a	a	DET
admet-376	365	23	cytotoxicity	cytotoxicity	NOUN
admet-376	365	24	system	system	NOUN
admet-376	365	25	based	base	VERB
admet-376	365	26	on	on	ADP
admet-376	365	27	gemcitabine	gemcitabine	NOUN
admet-376	365	28	,	,	PUNCT
admet-376	365	29	front	front	ADJ
admet-376	365	30	pharmacol	pharmacol	NOUN
admet-376	365	31	8	8	NUM
admet-376	365	32	(	(	PUNCT
admet-376	365	33	2017	2017	NUM
admet-376	365	34	)	)	PUNCT
admet-376	365	35	155	155	NUM
admet-376	365	36	.	.	PUNCT
admet-376	366	1	[	[	X
admet-376	366	2	21	21	NUM
admet-376	366	3	]	]	SYM
admet-376	366	4	d.b	d.b	PROPN
admet-376	366	5	.	.	PROPN
admet-376	366	6	kell	kell	PROPN
admet-376	366	7	.	.	PUNCT
admet-376	367	1	the	the	DET
admet-376	367	2	transporter	transporter	NOUN
admet-376	367	3	-	-	PUNCT
admet-376	367	4	mediated	mediate	VERB
admet-376	367	5	cellular	cellular	ADJ
admet-376	367	6	uptake	uptake	NOUN
admet-376	367	7	of	of	ADP
admet-376	367	8	pharmaceutical	pharmaceutical	ADJ
admet-376	367	9	drugs	drug	NOUN
admet-376	367	10	is	be	AUX
admet-376	367	11	based	base	VERB
admet-376	367	12	on	on	ADP
admet-376	367	13	their	their	PRON
admet-376	367	14	metabolite	metabolite	NOUN
admet-376	367	15	-	-	PUNCT
admet-376	367	16	likeness	likeness	NOUN
admet-376	367	17	and	and	CCONJ
admet-376	367	18	not	not	PART
admet-376	367	19	on	on	ADP
admet-376	367	20	their	their	PRON
admet-376	367	21	bulk	bulk	ADJ
admet-376	367	22	biophysical	biophysical	ADJ
admet-376	367	23	properties	property	NOUN
admet-376	367	24	:	:	PUNCT
admet-376	367	25	towards	towards	ADP
admet-376	367	26	a	a	DET
admet-376	367	27	systems	system	NOUN
admet-376	367	28	pharmacology	pharmacology	NOUN
admet-376	367	29	perspect	perspect	NOUN
admet-376	367	30	sci	sci	PROPN
admet-376	367	31	6	6	NUM
admet-376	367	32	(	(	PUNCT
admet-376	367	33	2015	2015	NUM
admet-376	367	34	)	)	PUNCT
admet-376	367	35	66	66	NUM
admet-376	367	36	-	-	SYM
admet-376	367	37	83	83	NUM
admet-376	367	38	.	.	PUNCT
admet-376	368	1	[	[	X
admet-376	368	2	22	22	NUM
admet-376	368	3	]	]	X
admet-376	368	4	s.	s.	PROPN
admet-376	368	5	o'hagan	o'hagan	PROPN
admet-376	368	6	,	,	PUNCT
admet-376	368	7	n.	n.	PROPN
admet-376	368	8	swainston	swainston	PROPN
admet-376	368	9	,	,	PUNCT
admet-376	368	10	j.	j.	PROPN
admet-376	368	11	handl	handl	PROPN
admet-376	368	12	,	,	PUNCT
admet-376	368	13	d.b	d.b	PROPN
admet-376	368	14	.	.	PROPN
admet-376	368	15	kell	kell	PROPN
admet-376	368	16	.	.	PUNCT
admet-376	369	1	a	a	DET
admet-376	369	2	‘	'	PUNCT
admet-376	369	3	rule	rule	NOUN
admet-376	369	4	of	of	ADP
admet-376	369	5	0.5′	0.5′	NUM
admet-376	369	6	for	for	ADP
admet-376	369	7	the	the	DET
admet-376	369	8	metabolite	metabolite	NOUN
admet-376	369	9	-	-	PUNCT
admet-376	369	10	likeness	likeness	NOUN
admet-376	369	11	of	of	ADP
admet-376	369	12	approved	approve	VERB
admet-376	369	13	pharmaceutical	pharmaceutical	ADJ
admet-376	369	14	drugs	drug	NOUN
admet-376	369	15	.	.	PUNCT
admet-376	369	16	,	,	PUNCT
admet-376	369	17	metabolomics	metabolomic	NOUN
admet-376	369	18	11	11	NUM
admet-376	369	19	(	(	PUNCT
admet-376	369	20	2015	2015	NUM
admet-376	369	21	)	)	PUNCT
admet-376	369	22	323	323	NUM
admet-376	369	23	-	-	SYM
admet-376	369	24	339	339	NUM
admet-376	369	25	.	.	PUNCT
admet-376	370	1	[	[	X
admet-376	370	2	23	23	NUM
admet-376	370	3	]	]	X
admet-376	370	4	s.	s.	PROPN
admet-376	370	5	o'hagan	o'hagan	PROPN
admet-376	370	6	,	,	PUNCT
admet-376	370	7	d.b	d.b	PROPN
admet-376	370	8	.	.	PROPN
admet-376	370	9	kell	kell	PROPN
admet-376	370	10	.	.	PUNCT
admet-376	371	1	understanding	understand	VERB
admet-376	371	2	the	the	DET
admet-376	371	3	foundations	foundation	NOUN
admet-376	371	4	of	of	ADP
admet-376	371	5	the	the	DET
admet-376	371	6	structural	structural	ADJ
admet-376	371	7	similarities	similarity	NOUN
admet-376	371	8	between	between	ADP
admet-376	371	9	marketed	market	VERB
admet-376	371	10	drugs	drug	NOUN
admet-376	371	11	and	and	CCONJ
admet-376	371	12	endogenous	endogenous	ADJ
admet-376	371	13	human	human	ADJ
admet-376	371	14	metabolites	metabolite	NOUN
admet-376	371	15	,	,	PUNCT
admet-376	371	16	front	front	ADJ
admet-376	371	17	pharmacol	pharmacol	NOUN
admet-376	371	18	6	6	NUM
admet-376	371	19	(	(	PUNCT
admet-376	371	20	2015	2015	NUM
admet-376	371	21	)	)	PUNCT
admet-376	371	22	105	105	NUM
admet-376	371	23	.	.	PUNCT
admet-376	372	1	[	[	X
admet-376	372	2	24	24	NUM
admet-376	372	3	]	]	X
admet-376	372	4	s.	s.	PROPN
admet-376	372	5	o'hagan	o'hagan	PROPN
admet-376	372	6	,	,	PUNCT
admet-376	372	7	d.b	d.b	PROPN
admet-376	372	8	.	.	PROPN
admet-376	372	9	kell	kell	PROPN
admet-376	372	10	.	.	PUNCT
admet-376	373	1	metmaxstruct	metmaxstruct	NOUN
admet-376	373	2	:	:	PUNCT
admet-376	373	3	a	a	DET
admet-376	373	4	tversky	tversky	ADJ
admet-376	373	5	-	-	PUNCT
admet-376	373	6	similarity	similarity	NOUN
admet-376	373	7	-	-	PUNCT
admet-376	373	8	based	base	VERB
admet-376	373	9	strategy	strategy	NOUN
admet-376	373	10	for	for	ADP
admet-376	373	11	analysing	analyse	VERB
admet-376	373	12	the	the	DET
admet-376	373	13	(	(	PUNCT
admet-376	373	14	sub)structural	sub)structural	ADJ
admet-376	373	15	similarities	similarity	NOUN
admet-376	373	16	of	of	ADP
admet-376	373	17	drugs	drug	NOUN
admet-376	373	18	and	and	CCONJ
admet-376	373	19	endogenous	endogenous	ADJ
admet-376	373	20	metabolites	metabolite	NOUN
admet-376	373	21	,	,	PUNCT
admet-376	373	22	front	front	ADJ
admet-376	373	23	pharmacol	pharmacol	NOUN
admet-376	373	24	7	7	NUM
admet-376	373	25	(	(	PUNCT
admet-376	373	26	2016	2016	NUM
admet-376	373	27	)	)	PUNCT
admet-376	373	28	266	266	NUM
admet-376	373	29	.	.	PUNCT
admet-376	374	1	[	[	X
admet-376	374	2	25	25	NUM
admet-376	374	3	]	]	PUNCT
admet-376	374	4	e.	e.	PROPN
admet-376	374	5	karakoc	karakoc	PROPN
admet-376	374	6	,	,	PUNCT
admet-376	374	7	s.c	s.c	PROPN
admet-376	374	8	.	.	PROPN
admet-376	374	9	sahinalp	sahinalp	PROPN
admet-376	374	10	,	,	PUNCT
admet-376	374	11	a.	a.	NOUN
admet-376	374	12	cherkasov	cherkasov	PROPN
admet-376	374	13	.	.	PUNCT
admet-376	375	1	comparative	comparative	ADJ
admet-376	375	2	qsarand	qsarand	NOUN
admet-376	375	3	fragments	fragment	VERB
admet-376	375	4	distribution	distribution	NOUN
admet-376	375	5	analysis	analysis	NOUN
admet-376	375	6	of	of	ADP
admet-376	375	7	drugs	drug	NOUN
admet-376	375	8	,	,	PUNCT
admet-376	375	9	druglikes	druglike	NOUN
admet-376	375	10	,	,	PUNCT
admet-376	375	11	metabolic	metabolic	NOUN
admet-376	375	12	substances	substance	NOUN
admet-376	375	13	,	,	PUNCT
admet-376	375	14	and	and	CCONJ
admet-376	375	15	antimicrobial	antimicrobial	ADJ
admet-376	375	16	compounds	compound	NOUN
admet-376	375	17	,	,	PUNCT
admet-376	375	18	j	j	PROPN
admet-376	375	19	chem	chem	PROPN
admet-376	375	20	inf	inf	PROPN
admet-376	375	21	model	model	NOUN
admet-376	375	22	46	46	NUM
admet-376	375	23	(	(	PUNCT
admet-376	375	24	2006	2006	NUM
admet-376	375	25	)	)	PUNCT
admet-376	375	26	2167	2167	NUM
admet-376	375	27	-	-	SYM
admet-376	375	28	2182	2182	NUM
admet-376	375	29	.	.	PUNCT
admet-376	376	1	[	[	X
admet-376	376	2	26	26	NUM
admet-376	376	3	]	]	X
admet-376	376	4	s.	s.	PROPN
admet-376	376	5	gupta	gupta	PROPN
admet-376	376	6	,	,	PUNCT
admet-376	376	7	j.	j.	PROPN
admet-376	376	8	aires	aires	PROPN
admet-376	376	9	-	-	PUNCT
admet-376	376	10	de	de	NOUN
admet-376	376	11	-	-	NOUN
admet-376	376	12	sousa	sousa	NOUN
admet-376	376	13	.	.	PUNCT
admet-376	376	14	comparing	compare	VERB
admet-376	376	15	the	the	DET
admet-376	376	16	chemical	chemical	ADJ
admet-376	376	17	spaces	space	NOUN
admet-376	376	18	of	of	ADP
admet-376	376	19	metabolites	metabolite	NOUN
admet-376	376	20	and	and	CCONJ
admet-376	376	21	available	available	ADJ
admet-376	376	22	chemicals	chemical	NOUN
admet-376	376	23	:	:	PUNCT
admet-376	376	24	models	model	NOUN
admet-376	376	25	of	of	ADP
admet-376	376	26	metabolite	metabolite	NOUN
admet-376	376	27	-	-	PUNCT
admet-376	376	28	likeness	likeness	NOUN
admet-376	376	29	,	,	PUNCT
admet-376	376	30	mol	mol	ADP
admet-376	376	31	divers	diver	NOUN
admet-376	376	32	11	11	NUM
admet-376	376	33	(	(	PUNCT
admet-376	376	34	2007	2007	NUM
admet-376	376	35	)	)	PUNCT
admet-376	376	36	23	23	NUM
admet-376	376	37	-	-	SYM
admet-376	376	38	36	36	NUM
admet-376	376	39	.	.	PUNCT
admet-376	377	1	[	[	X
admet-376	377	2	27	27	NUM
admet-376	377	3	]	]	X
admet-376	377	4	v.	v.	CCONJ
admet-376	377	5	khanna	khanna	PROPN
admet-376	377	6	,	,	PUNCT
admet-376	377	7	s.	s.	PROPN
admet-376	377	8	ranganathan	ranganathan	PROPN
admet-376	377	9	.	.	PUNCT
admet-376	378	1	physicochemical	physicochemical	ADJ
admet-376	378	2	property	property	NOUN
admet-376	378	3	space	space	NOUN
admet-376	378	4	distribution	distribution	NOUN
admet-376	378	5	among	among	ADP
admet-376	378	6	human	human	ADJ
admet-376	378	7	metabolites	metabolite	NOUN
admet-376	378	8	,	,	PUNCT
admet-376	378	9	drugs	drug	NOUN
admet-376	378	10	and	and	CCONJ
admet-376	378	11	toxins	toxin	NOUN
admet-376	378	12	,	,	PUNCT
admet-376	378	13	bmc	bmc	ADJ
admet-376	378	14	bioinformatics	bioinformatics	NOUN
admet-376	378	15	10	10	NUM
admet-376	378	16	(	(	PUNCT
admet-376	378	17	2009	2009	NUM
admet-376	378	18	)	)	PUNCT
admet-376	378	19	s10	s10	NOUN
admet-376	378	20	.	.	PUNCT
admet-376	379	1	[	[	X
admet-376	379	2	28	28	NUM
admet-376	379	3	]	]	X
admet-376	379	4	j.e	j.e	PROPN
admet-376	379	5	.	.	PROPN
admet-376	379	6	peironcely	peironcely	ADV
admet-376	379	7	,	,	PUNCT
admet-376	379	8	t.	t.	NOUN
admet-376	379	9	reijmers	reijmer	NOUN
admet-376	379	10	,	,	PUNCT
admet-376	379	11	l.	l.	PROPN
admet-376	379	12	coulier	coulier	PROPN
admet-376	379	13	,	,	PUNCT
admet-376	379	14	a.	a.	NOUN
admet-376	379	15	bender	bender	PROPN
admet-376	379	16	,	,	PUNCT
admet-376	379	17	t.	t.	NOUN
admet-376	379	18	hankemeier	hankemeier	NOUN
admet-376	379	19	.	.	PUNCT
admet-376	380	1	understanding	understanding	NOUN
admet-376	380	2	and	and	CCONJ
admet-376	380	3	classifying	classify	VERB
admet-376	380	4	metabolite	metabolite	NOUN
admet-376	380	5	space	space	NOUN
admet-376	380	6	and	and	CCONJ
admet-376	380	7	metabolite	metabolite	NOUN
admet-376	380	8	-	-	PUNCT
admet-376	380	9	likeness	likeness	NOUN
admet-376	380	10	,	,	PUNCT
admet-376	380	11	plos	plos	PROPN
admet-376	380	12	one	one	NUM
admet-376	380	13	6	6	NUM
admet-376	380	14	(	(	PUNCT
admet-376	380	15	2011	2011	NUM
admet-376	380	16	)	)	PUNCT
admet-376	380	17	e28966	e28966	NOUN
admet-376	380	18	.	.	PUNCT
admet-376	381	1	[	[	X
admet-376	381	2	29	29	NUM
admet-376	381	3	]	]	X
admet-376	381	4	m.a	m.a	PROPN
admet-376	381	5	.	.	PROPN
admet-376	381	6	hamdalla	hamdalla	PROPN
admet-376	381	7	,	,	PUNCT
admet-376	381	8	mandoiu	mandoiu	NOUN
admet-376	381	9	,	,	PUNCT
admet-376	381	10	ii	ii	PROPN
admet-376	381	11	,	,	PUNCT
admet-376	381	12	d.w	d.w	PROPN
admet-376	381	13	.	.	PROPN
admet-376	381	14	hill	hill	PROPN
admet-376	381	15	,	,	PUNCT
admet-376	381	16	s.	s.	PROPN
admet-376	381	17	rajasekaran	rajasekaran	PROPN
admet-376	381	18	,	,	PUNCT
admet-376	381	19	d.f	d.f	PROPN
admet-376	381	20	.	.	PROPN
admet-376	381	21	grant	grant	PROPN
admet-376	381	22	.	.	PUNCT
admet-376	381	23	biosm	biosm	NOUN
admet-376	381	24	:	:	PUNCT
admet-376	381	25	metabolomics	metabolomic	NOUN
admet-376	381	26	tool	tool	NOUN
admet-376	381	27	for	for	ADP
admet-376	381	28	identifying	identify	VERB
admet-376	381	29	endogenous	endogenous	ADJ
admet-376	381	30	mammalian	mammalian	ADJ
admet-376	381	31	biochemical	biochemical	ADJ
admet-376	381	32	structures	structure	NOUN
admet-376	381	33	in	in	ADP
admet-376	381	34	chemical	chemical	ADJ
admet-376	381	35	structure	structure	NOUN
admet-376	381	36	space	space	NOUN
admet-376	381	37	,	,	PUNCT
admet-376	381	38	j	j	PROPN
admet-376	381	39	chem	chem	PROPN
admet-376	381	40	inf	inf	PROPN
admet-376	381	41	model	model	NOUN
admet-376	381	42	53	53	NUM
admet-376	381	43	(	(	PUNCT
admet-376	381	44	2013	2013	NUM
admet-376	381	45	)	)	PUNCT
admet-376	381	46	601	601	NUM
admet-376	381	47	-	-	NUM
admet-376	381	48	612	612	NUM
admet-376	381	49	.	.	PUNCT
admet-376	382	1	[	[	X
admet-376	382	2	30	30	NUM
admet-376	382	3	]	]	X
admet-376	382	4	s.k	s.k	PROPN
admet-376	382	5	.	.	PROPN
admet-376	382	6	nigam	nigam	PROPN
admet-376	382	7	.	.	PUNCT
admet-376	383	1	what	what	PRON
admet-376	383	2	do	do	AUX
admet-376	383	3	drug	drug	NOUN
admet-376	383	4	transporters	transporter	NOUN
admet-376	383	5	really	really	ADV
admet-376	383	6	do	do	VERB
admet-376	383	7	?	?	PUNCT
admet-376	383	8	,	,	PUNCT
admet-376	383	9	nat	nat	PROPN
admet-376	383	10	rev	rev	VERB
admet-376	383	11	drug	drug	PROPN
admet-376	383	12	discov	discov	PROPN
admet-376	383	13	14	14	NUM
admet-376	383	14	(	(	PUNCT
admet-376	383	15	2015	2015	NUM
admet-376	383	16	)	)	PUNCT
admet-376	383	17	29	29	NUM
admet-376	383	18	-	-	SYM
admet-376	383	19	44	44	NUM
admet-376	383	20	.	.	PUNCT
admet-376	384	1	[	[	X
admet-376	384	2	31	31	NUM
admet-376	384	3	]	]	X
admet-376	384	4	m.a	m.a	PROPN
admet-376	384	5	.	.	PROPN
admet-376	384	6	johnson	johnson	PROPN
admet-376	384	7	,	,	PUNCT
admet-376	384	8	g.m	g.m	PROPN
admet-376	384	9	.	.	PROPN
admet-376	384	10	maggiora	maggiora	PROPN
admet-376	384	11	,	,	PUNCT
admet-376	384	12	concepts	concept	NOUN
admet-376	384	13	and	and	CCONJ
admet-376	384	14	applications	application	NOUN
admet-376	384	15	of	of	ADP
admet-376	384	16	molecular	molecular	ADJ
admet-376	384	17	similarity	similarity	NOUN
admet-376	384	18	,	,	PUNCT
admet-376	384	19	wiley	wiley	NOUN
admet-376	384	20	,	,	PUNCT
admet-376	384	21	new	new	PROPN
admet-376	384	22	york	york	PROPN
admet-376	384	23	,	,	PUNCT
admet-376	384	24	1990	1990	NUM
admet-376	384	25	.	.	PUNCT
admet-376	385	1	[	[	X
admet-376	385	2	32	32	NUM
admet-376	385	3	]	]	PUNCT
admet-376	385	4	h.	h.	PROPN
admet-376	385	5	kubinyi	kubinyi	PROPN
admet-376	385	6	.	.	PUNCT
admet-376	385	7	similarity	similarity	NOUN
admet-376	385	8	and	and	CCONJ
admet-376	385	9	dissimilarity	dissimilarity	NOUN
admet-376	385	10	:	:	PUNCT
admet-376	385	11	a	a	DET
admet-376	385	12	medicinal	medicinal	ADJ
admet-376	385	13	chemist	chemist	NOUN
admet-376	385	14	's	's	PART
admet-376	385	15	view	view	NOUN
admet-376	385	16	,	,	PUNCT
admet-376	385	17	perspect	perspect	VERB
admet-376	385	18	drug	drug	NOUN
admet-376	385	19	discov	discov	NOUN
admet-376	385	20	des	des	PROPN
admet-376	385	21	9	9	NUM
admet-376	385	22	-	-	SYM
admet-376	385	23	11	11	NUM
admet-376	385	24	(	(	PUNCT
admet-376	385	25	1998	1998	NUM
admet-376	385	26	)	)	PUNCT
admet-376	385	27	225	225	NUM
admet-376	385	28	-	-	SYM
admet-376	385	29	252	252	NUM
admet-376	385	30	.	.	PUNCT
admet-376	386	1	[	[	X
admet-376	386	2	33	33	NUM
admet-376	386	3	]	]	X
admet-376	386	4	s.m	s.m	PROPN
admet-376	386	5	.	.	PROPN
admet-376	386	6	arif	arif	PROPN
admet-376	386	7	,	,	PUNCT
admet-376	386	8	j.d	j.d	PROPN
admet-376	386	9	.	.	PROPN
admet-376	386	10	holliday	holliday	PROPN
admet-376	386	11	,	,	PUNCT
admet-376	386	12	p.	p.	PROPN
admet-376	386	13	willett	willett	PROPN
admet-376	386	14	.	.	PUNCT
admet-376	387	1	comparison	comparison	NOUN
admet-376	387	2	of	of	ADP
admet-376	387	3	chemical	chemical	NOUN
admet-376	387	4	similarity	similarity	NOUN
admet-376	387	5	measures	measure	NOUN
admet-376	387	6	using	use	VERB
admet-376	387	7	different	different	ADJ
admet-376	387	8	numbers	number	NOUN
admet-376	387	9	of	of	ADP
admet-376	387	10	query	query	NOUN
admet-376	387	11	structures	structure	NOUN
admet-376	387	12	,	,	PUNCT
admet-376	387	13	j	j	PROPN
admet-376	387	14	inf	inf	PROPN
admet-376	387	15	sci	sci	PROPN
admet-376	387	16	39	39	NUM
admet-376	387	17	(	(	PUNCT
admet-376	387	18	2013	2013	NUM
admet-376	387	19	)	)	PUNCT
admet-376	387	20	7	7	NUM
admet-376	387	21	-	-	SYM
admet-376	387	22	14	14	NUM
admet-376	387	23	.	.	PUNCT
admet-376	388	1	[	[	X
admet-376	388	2	34	34	NUM
admet-376	388	3	]	]	X
admet-376	388	4	p.	p.	PROPN
admet-376	388	5	baldi	baldi	PROPN
admet-376	388	6	,	,	PUNCT
admet-376	388	7	r.	r.	PROPN
admet-376	388	8	nasr	nasr	PROPN
admet-376	388	9	.	.	PUNCT
admet-376	389	1	when	when	SCONJ
admet-376	389	2	is	be	AUX
admet-376	389	3	chemical	chemical	ADJ
admet-376	389	4	similarity	similarity	NOUN
admet-376	389	5	significant	significant	ADJ
admet-376	389	6	?	?	PUNCT
admet-376	390	1	the	the	DET
admet-376	390	2	statistical	statistical	ADJ
admet-376	390	3	distribution	distribution	NOUN
admet-376	390	4	of	of	ADP
admet-376	390	5	chemical	chemical	ADJ
admet-376	390	6	similarity	similarity	NOUN
admet-376	390	7	scores	score	NOUN
admet-376	390	8	and	and	CCONJ
admet-376	390	9	its	its	PRON
admet-376	390	10	extreme	extreme	ADJ
admet-376	390	11	values	value	NOUN
admet-376	390	12	,	,	PUNCT
admet-376	390	13	j	j	PROPN
admet-376	390	14	chem	chem	PROPN
admet-376	390	15	inf	inf	PROPN
admet-376	390	16	model	model	NOUN
admet-376	390	17	50	50	NUM
admet-376	390	18	(	(	PUNCT
admet-376	390	19	2010	2010	NUM
admet-376	390	20	)	)	PUNCT
admet-376	390	21	1205	1205	NUM
admet-376	390	22	-	-	SYM
admet-376	390	23	1222	1222	NUM
admet-376	390	24	.	.	PUNCT
admet-376	391	1	[	[	X
admet-376	391	2	35	35	NUM
admet-376	391	3	]	]	X
admet-376	391	4	r.p	r.p	PROPN
admet-376	391	5	.	.	PROPN
admet-376	391	6	sheridan	sheridan	PROPN
admet-376	391	7	.	.	PUNCT
admet-376	392	1	chemical	chemical	PROPN
admet-376	392	2	similarity	similarity	NOUN
admet-376	392	3	searches	search	NOUN
admet-376	392	4	:	:	PUNCT
admet-376	392	5	when	when	SCONJ
admet-376	392	6	is	be	AUX
admet-376	392	7	complexity	complexity	NOUN
admet-376	392	8	justified	justify	VERB
admet-376	392	9	?	?	PUNCT
admet-376	392	10	,	,	PUNCT
admet-376	392	11	expert	expert	NOUN
admet-376	392	12	opin	opin	NOUN
admet-376	392	13	drug	drug	NOUN
admet-376	392	14	discov	discov	NOUN
admet-376	392	15	2	2	NUM
admet-376	392	16	(	(	PUNCT
admet-376	392	17	2007	2007	NUM
admet-376	392	18	)	)	PUNCT
admet-376	392	19	423	423	NUM
admet-376	392	20	-	-	SYM
admet-376	392	21	430	430	NUM
admet-376	392	22	.	.	PUNCT
admet-376	393	1	[	[	X
admet-376	393	2	36	36	NUM
admet-376	393	3	]	]	X
admet-376	393	4	r.	r.	PROPN
admet-376	393	5	todeschini	todeschini	PROPN
admet-376	393	6	,	,	PUNCT
admet-376	393	7	v.	v.	PROPN
admet-376	393	8	consonni	consonni	PROPN
admet-376	393	9	,	,	PUNCT
admet-376	393	10	molecular	molecular	ADJ
admet-376	393	11	descriptors	descriptor	NOUN
admet-376	393	12	for	for	ADP
admet-376	393	13	cheminformatics	cheminformatic	NOUN
admet-376	393	14	,	,	PUNCT
admet-376	393	15	wiley	wiley	PROPN
admet-376	393	16	-	-	PUNCT
admet-376	393	17	vch	vch	PROPN
admet-376	393	18	verlag	verlag	PROPN
admet-376	393	19	gmbh	gmbh	PROPN
admet-376	393	20	,	,	PUNCT
admet-376	393	21	weinheim	weinheim	PROPN
admet-376	393	22	,	,	PUNCT
admet-376	393	23	2009	2009	NUM
admet-376	393	24	.	.	PUNCT
admet-376	394	1	[	[	X
admet-376	394	2	37	37	NUM
admet-376	394	3	]	]	X
admet-376	394	4	p.	p.	NOUN
admet-376	394	5	willett	willett	PROPN
admet-376	394	6	,	,	PUNCT
admet-376	394	7	j.m	j.m	PROPN
admet-376	394	8	.	.	PROPN
admet-376	394	9	barnard	barnard	PROPN
admet-376	394	10	,	,	PUNCT
admet-376	394	11	g.m	g.m	PROPN
admet-376	394	12	.	.	PROPN
admet-376	394	13	downs	down	NOUN
admet-376	394	14	.	.	PUNCT
admet-376	395	1	chemical	chemical	NOUN
admet-376	395	2	similarity	similarity	PROPN
admet-376	395	3	searching	searching	NOUN
admet-376	395	4	,	,	PUNCT
admet-376	395	5	j	j	PROPN
admet-376	395	6	chem	chem	PROPN
admet-376	395	7	inf	inf	PROPN
admet-376	395	8	comp	comp	NOUN
admet-376	395	9	sci	sci	PROPN
admet-376	395	10	38	38	NUM
admet-376	395	11	(	(	PUNCT
admet-376	395	12	1998	1998	NUM
admet-376	395	13	)	)	PUNCT
admet-376	395	14	983	983	NUM
admet-376	395	15	-	-	SYM
admet-376	395	16	996	996	NUM
admet-376	395	17	.	.	PUNCT
admet-376	396	1	[	[	X
admet-376	396	2	38	38	NUM
admet-376	396	3	]	]	PUNCT
admet-376	396	4	d.	d.	PROPN
admet-376	396	5	stumpfe	stumpfe	PROPN
admet-376	396	6	,	,	PUNCT
admet-376	396	7	j.	j.	PROPN
admet-376	396	8	bajorath	bajorath	PROPN
admet-376	396	9	.	.	PUNCT
admet-376	397	1	similarity	similarity	NOUN
admet-376	397	2	searching	searching	NOUN
admet-376	397	3	,	,	PUNCT
admet-376	397	4	wires	wire	NOUN
admet-376	397	5	comput	comput	VERB
admet-376	397	6	mol	mol	ADP
admet-376	397	7	sci	sci	PROPN
admet-376	397	8	1	1	NUM
admet-376	397	9	(	(	PUNCT
admet-376	397	10	2011	2011	NUM
admet-376	397	11	)	)	PUNCT
admet-376	397	12	260	260	NUM
admet-376	397	13	-	-	SYM
admet-376	397	14	282	282	NUM
admet-376	397	15	.	.	PUNCT
admet-376	398	1	[	[	X
admet-376	398	2	39	39	NUM
admet-376	398	3	]	]	PUNCT
admet-376	398	4	p.	p.	NOUN
admet-376	398	5	willett	willett	PROPN
admet-376	398	6	.	.	PUNCT
admet-376	399	1	the	the	DET
admet-376	399	2	calculation	calculation	NOUN
admet-376	399	3	of	of	ADP
admet-376	399	4	molecular	molecular	ADJ
admet-376	399	5	structural	structural	ADJ
admet-376	399	6	similarity	similarity	NOUN
admet-376	399	7	:	:	PUNCT
admet-376	399	8	principles	principle	NOUN
admet-376	399	9	and	and	CCONJ
admet-376	399	10	practice	practice	NOUN
admet-376	399	11	,	,	PUNCT
admet-376	399	12	mol	mol	ADP
admet-376	399	13	inform	inform	NOUN
admet-376	399	14	33	33	NUM
admet-376	399	15	(	(	PUNCT
admet-376	399	16	2014	2014	NUM
admet-376	399	17	)	)	PUNCT
admet-376	399	18	403	403	NUM
admet-376	399	19	-	-	SYM
admet-376	399	20	413	413	NUM
admet-376	399	21	.	.	PUNCT
admet-376	399	22	o'hagan	o'hagan	PROPN
admet-376	399	23	&	&	CCONJ
admet-376	399	24	kell	kell	PROPN
admet-376	399	25	admet	admet	PROPN
admet-376	399	26	&	&	CCONJ
admet-376	399	27	dmpk	dmpk	PROPN
admet-376	399	28	5(2	5(2	NUM
admet-376	399	29	)	)	PUNCT
admet-376	399	30	(	(	PUNCT
admet-376	399	31	2017	2017	NUM
admet-376	399	32	)	)	PUNCT
admet-376	399	33	85	85	NUM
admet-376	399	34	-	-	SYM
admet-376	399	35	125	125	NUM
admet-376	399	36	116	116	NUM
admet-376	399	37	[	[	X
admet-376	399	38	40	40	NUM
admet-376	399	39	]	]	PUNCT
admet-376	399	40	l.	l.	PROPN
admet-376	399	41	peltason	peltason	PROPN
admet-376	399	42	,	,	PUNCT
admet-376	399	43	p.	p.	PROPN
admet-376	399	44	iyer	iyer	PROPN
admet-376	399	45	,	,	PUNCT
admet-376	399	46	j.	j.	PROPN
admet-376	399	47	bajorath	bajorath	PROPN
admet-376	399	48	.	.	PUNCT
admet-376	400	1	rationalizing	rationalize	VERB
admet-376	400	2	three	three	NUM
admet-376	400	3	-	-	PUNCT
admet-376	400	4	dimensional	dimensional	ADJ
admet-376	400	5	activity	activity	NOUN
admet-376	400	6	landscapes	landscape	NOUN
admet-376	400	7	and	and	CCONJ
admet-376	400	8	the	the	DET
admet-376	400	9	influence	influence	NOUN
admet-376	400	10	of	of	ADP
admet-376	400	11	molecular	molecular	ADJ
admet-376	400	12	representations	representation	NOUN
admet-376	400	13	on	on	ADP
admet-376	400	14	landscape	landscape	NOUN
admet-376	400	15	topology	topology	NOUN
admet-376	400	16	and	and	CCONJ
admet-376	400	17	the	the	DET
admet-376	400	18	formation	formation	NOUN
admet-376	400	19	of	of	ADP
admet-376	400	20	activity	activity	NOUN
admet-376	400	21	cliffs	cliff	NOUN
admet-376	400	22	,	,	PUNCT
admet-376	400	23	j	j	PROPN
admet-376	400	24	chem	chem	PROPN
admet-376	400	25	inf	inf	PROPN
admet-376	400	26	model	model	NOUN
admet-376	400	27	50	50	NUM
admet-376	400	28	(	(	PUNCT
admet-376	400	29	2010	2010	NUM
admet-376	400	30	)	)	PUNCT
admet-376	400	31	1021	1021	NUM
admet-376	400	32	-	-	SYM
admet-376	400	33	1033	1033	NUM
admet-376	400	34	.	.	PUNCT
admet-376	401	1	[	[	X
admet-376	401	2	41	41	NUM
admet-376	401	3	]	]	X
admet-376	401	4	a.m.	a.m.	NOUN
admet-376	401	5	wassermann	wassermann	PROPN
admet-376	401	6	,	,	PUNCT
admet-376	401	7	m.	m.	NOUN
admet-376	401	8	wawer	wawer	NOUN
admet-376	401	9	,	,	PUNCT
admet-376	401	10	j.	j.	PROPN
admet-376	401	11	bajorath	bajorath	PROPN
admet-376	401	12	.	.	PUNCT
admet-376	402	1	activity	activity	NOUN
admet-376	402	2	landscape	landscape	NOUN
admet-376	402	3	representations	representation	NOUN
admet-376	402	4	for	for	ADP
admet-376	402	5	structure	structure	NOUN
admet-376	402	6	-	-	PUNCT
admet-376	402	7	activity	activity	NOUN
admet-376	402	8	relationship	relationship	NOUN
admet-376	402	9	analysis	analysis	NOUN
admet-376	402	10	,	,	PUNCT
admet-376	402	11	j	j	PROPN
admet-376	402	12	med	med	PROPN
admet-376	402	13	chem	chem	NOUN
admet-376	402	14	(	(	PUNCT
admet-376	402	15	2010	2010	NUM
admet-376	402	16	)	)	PUNCT
admet-376	402	17	.	.	PUNCT
admet-376	403	1	[	[	X
admet-376	403	2	42	42	NUM
admet-376	403	3	]	]	PUNCT
admet-376	403	4	m.	m.	NOUN
admet-376	403	5	cruz	cruz	PROPN
admet-376	403	6	-	-	PUNCT
admet-376	403	7	monteagudo	monteagudo	PROPN
admet-376	403	8	,	,	PUNCT
admet-376	403	9	j.l	j.l	PROPN
admet-376	403	10	.	.	PROPN
admet-376	403	11	medina	medina	PROPN
admet-376	403	12	-	-	PUNCT
admet-376	403	13	franco	franco	PROPN
admet-376	403	14	,	,	PUNCT
admet-376	403	15	y.	y.	PROPN
admet-376	403	16	pérez	pérez	PROPN
admet-376	403	17	-	-	PUNCT
admet-376	403	18	castillo	castillo	PROPN
admet-376	403	19	,	,	PUNCT
admet-376	403	20	o.	o.	PROPN
admet-376	403	21	nicolotti	nicolotti	PROPN
admet-376	403	22	,	,	PUNCT
admet-376	403	23	m.n.d.s	m.n.d.s	PROPN
admet-376	403	24	.	.	PUNCT
admet-376	403	25	cordeiro	cordeiro	PROPN
admet-376	403	26	,	,	PUNCT
admet-376	403	27	f.	f.	PROPN
admet-376	403	28	borges	borges	PROPN
admet-376	403	29	.	.	PUNCT
admet-376	404	1	activity	activity	NOUN
admet-376	404	2	cliffs	cliff	NOUN
admet-376	404	3	in	in	ADP
admet-376	404	4	drug	drug	NOUN
admet-376	404	5	discovery	discovery	NOUN
admet-376	404	6	:	:	PUNCT
admet-376	404	7	dr	dr	PROPN
admet-376	404	8	jekyll	jekyll	PROPN
admet-376	404	9	or	or	CCONJ
admet-376	404	10	mr	mr	PROPN
admet-376	404	11	hyde	hyde	PROPN
admet-376	404	12	?	?	PROPN
admet-376	404	13	,	,	PUNCT
admet-376	404	14	drug	drug	NOUN
admet-376	404	15	discov	discov	NOUN
admet-376	404	16	today	today	NOUN
admet-376	404	17	19	19	NUM
admet-376	404	18	(	(	PUNCT
admet-376	404	19	2014	2014	NUM
admet-376	404	20	)	)	PUNCT
admet-376	404	21	1069	1069	NUM
admet-376	404	22	-	-	SYM
admet-376	404	23	1080	1080	NUM
admet-376	404	24	.	.	PUNCT
admet-376	405	1	[	[	X
admet-376	405	2	43	43	NUM
admet-376	405	3	]	]	X
admet-376	405	4	y.c	y.c	PROPN
admet-376	405	5	.	.	PROPN
admet-376	405	6	martin	martin	PROPN
admet-376	405	7	,	,	PUNCT
admet-376	405	8	j.l	j.l	PROPN
admet-376	405	9	.	.	PROPN
admet-376	405	10	kofron	kofron	PROPN
admet-376	405	11	,	,	PUNCT
admet-376	405	12	l.m	l.m	PROPN
admet-376	405	13	.	.	PROPN
admet-376	405	14	traphagen	traphagen	PROPN
admet-376	405	15	.	.	PUNCT
admet-376	406	1	do	do	AUX
admet-376	406	2	structurally	structurally	ADV
admet-376	406	3	similar	similar	ADJ
admet-376	406	4	molecules	molecule	NOUN
admet-376	406	5	have	have	VERB
admet-376	406	6	similar	similar	ADJ
admet-376	406	7	biological	biological	ADJ
admet-376	406	8	activity	activity	NOUN
admet-376	406	9	?	?	PUNCT
admet-376	406	10	,	,	PUNCT
admet-376	406	11	j	j	PROPN
admet-376	406	12	med	med	PROPN
admet-376	406	13	chem	chem	NOUN
admet-376	406	14	45	45	NUM
admet-376	406	15	(	(	PUNCT
admet-376	406	16	2002	2002	NUM
admet-376	406	17	)	)	PUNCT
admet-376	406	18	4350	4350	NUM
admet-376	406	19	-	-	SYM
admet-376	406	20	4358	4358	NUM
admet-376	406	21	.	.	PUNCT
admet-376	407	1	[	[	X
admet-376	407	2	44	44	NUM
admet-376	407	3	]	]	X
admet-376	407	4	w.j	w.j	PROPN
admet-376	407	5	.	.	PROPN
admet-376	407	6	albery	albery	PROPN
admet-376	407	7	,	,	PUNCT
admet-376	407	8	j.r	j.r	PROPN
admet-376	407	9	.	.	PROPN
admet-376	407	10	knowles	knowles	PROPN
admet-376	407	11	.	.	PUNCT
admet-376	408	1	evolution	evolution	NOUN
admet-376	408	2	of	of	ADP
admet-376	408	3	enzyme	enzyme	NOUN
admet-376	408	4	function	function	NOUN
admet-376	408	5	and	and	CCONJ
admet-376	408	6	the	the	DET
admet-376	408	7	development	development	NOUN
admet-376	408	8	of	of	ADP
admet-376	408	9	catalytic	catalytic	ADJ
admet-376	408	10	efficiency	efficiency	NOUN
admet-376	408	11	,	,	PUNCT
admet-376	408	12	biochemistry	biochemistry	NOUN
admet-376	408	13	15	15	NUM
admet-376	408	14	(	(	PUNCT
admet-376	408	15	1976	1976	NUM
admet-376	408	16	)	)	PUNCT
admet-376	408	17	5631	5631	NUM
admet-376	408	18	-	-	SYM
admet-376	408	19	5640	5640	NUM
admet-376	408	20	.	.	PUNCT
admet-376	409	1	[	[	X
admet-376	409	2	45	45	NUM
admet-376	409	3	]	]	PUNCT
admet-376	409	4	a.	a.	NOUN
admet-376	409	5	fersht	fersht	NOUN
admet-376	409	6	,	,	PUNCT
admet-376	409	7	enzyme	enzyme	NOUN
admet-376	409	8	structure	structure	NOUN
admet-376	409	9	and	and	CCONJ
admet-376	409	10	mechanism	mechanism	NOUN
admet-376	409	11	,	,	PUNCT
admet-376	409	12	2nd	2nd	ADJ
admet-376	409	13	ed	ed	NOUN
admet-376	409	14	.	.	PROPN
admet-376	409	15	,	,	PUNCT
admet-376	409	16	w.h	w.h	PROPN
admet-376	409	17	.	.	PROPN
admet-376	409	18	freeman	freeman	PROPN
admet-376	409	19	,	,	PUNCT
admet-376	409	20	san	san	PROPN
admet-376	409	21	francisco	francisco	PROPN
admet-376	409	22	,	,	PUNCT
admet-376	409	23	1977	1977	NUM
admet-376	409	24	.	.	PUNCT
admet-376	410	1	[	[	X
admet-376	410	2	46	46	NUM
admet-376	410	3	]	]	PUNCT
admet-376	410	4	t.	t.	PROPN
admet-376	410	5	keleti	keleti	PROPN
admet-376	410	6	,	,	PUNCT
admet-376	410	7	basic	basic	ADJ
admet-376	410	8	enzyme	enzyme	NOUN
admet-376	410	9	kinetics	kinetic	NOUN
admet-376	410	10	,	,	PUNCT
admet-376	410	11	akadémiai	akadémiai	ADJ
admet-376	410	12	kiadó	kiadó	PROPN
admet-376	410	13	,	,	PUNCT
admet-376	410	14	budapest	budapest	PROPN
admet-376	410	15	,	,	PUNCT
admet-376	410	16	1986	1986	NUM
admet-376	410	17	.	.	PUNCT
admet-376	411	1	[	[	X
admet-376	411	2	47	47	NUM
admet-376	411	3	]	]	X
admet-376	411	4	a.	a.	PROPN
admet-376	411	5	cornish	cornish	PROPN
admet-376	411	6	-	-	PUNCT
admet-376	411	7	bowden	bowden	PROPN
admet-376	411	8	,	,	PUNCT
admet-376	411	9	fundamentals	fundamental	NOUN
admet-376	411	10	of	of	ADP
admet-376	411	11	enzyme	enzyme	NOUN
admet-376	411	12	kinetics	kinetic	NOUN
admet-376	411	13	,	,	PUNCT
admet-376	411	14	2nd	2nd	ADJ
admet-376	411	15	ed	ed	NOUN
admet-376	411	16	.	.	PROPN
admet-376	411	17	,	,	PUNCT
admet-376	411	18	portland	portland	PROPN
admet-376	411	19	press	press	PROPN
admet-376	411	20	,	,	PUNCT
admet-376	411	21	london	london	PROPN
admet-376	411	22	,	,	PUNCT
admet-376	411	23	1995	1995	NUM
admet-376	411	24	.	.	PUNCT
admet-376	412	1	[	[	X
admet-376	412	2	48	48	NUM
admet-376	412	3	]	]	X
admet-376	412	4	b.d	b.d	PROPN
admet-376	412	5	.	.	PROPN
admet-376	412	6	paul	paul	PROPN
admet-376	412	7	,	,	PUNCT
admet-376	412	8	s.h	s.h	PROPN
admet-376	412	9	.	.	PROPN
admet-376	412	10	snyder	snyder	PROPN
admet-376	412	11	.	.	PUNCT
admet-376	413	1	the	the	DET
admet-376	413	2	unusual	unusual	ADJ
admet-376	413	3	amino	amino	NOUN
admet-376	413	4	acid	acid	NOUN
admet-376	413	5	l	l	NOUN
admet-376	413	6	-	-	NOUN
admet-376	413	7	ergothioneine	ergothioneine	NOUN
admet-376	413	8	is	be	AUX
admet-376	413	9	a	a	DET
admet-376	413	10	physiologic	physiologic	ADJ
admet-376	413	11	cytoprotectant	cytoprotectant	NOUN
admet-376	413	12	,	,	PUNCT
admet-376	413	13	cell	cell	NOUN
admet-376	413	14	death	death	NOUN
admet-376	413	15	differ	differ	VERB
admet-376	413	16	17	17	NUM
admet-376	413	17	(	(	PUNCT
admet-376	413	18	2010	2010	NUM
admet-376	413	19	)	)	PUNCT
admet-376	413	20	1134	1134	NUM
admet-376	413	21	-	-	SYM
admet-376	413	22	1140	1140	NUM
admet-376	413	23	.	.	PUNCT
admet-376	414	1	[	[	X
admet-376	414	2	49	49	NUM
admet-376	414	3	]	]	X
admet-376	414	4	i.k	i.k	PROPN
admet-376	414	5	.	.	PROPN
admet-376	414	6	cheah	cheah	PROPN
admet-376	414	7	,	,	PUNCT
admet-376	414	8	b.	b.	PROPN
admet-376	414	9	halliwell	halliwell	PROPN
admet-376	414	10	.	.	PUNCT
admet-376	414	11	ergothioneine	ergothioneine	PROPN
admet-376	414	12	;	;	PUNCT
admet-376	414	13	antioxidant	antioxidant	ADJ
admet-376	414	14	potential	potential	NOUN
admet-376	414	15	,	,	PUNCT
admet-376	414	16	physiological	physiological	ADJ
admet-376	414	17	function	function	NOUN
admet-376	414	18	and	and	CCONJ
admet-376	414	19	role	role	NOUN
admet-376	414	20	in	in	ADP
admet-376	414	21	disease	disease	NOUN
admet-376	414	22	,	,	PUNCT
admet-376	414	23	biochim	biochim	PROPN
admet-376	414	24	biophys	biophy	NOUN
admet-376	414	25	acta	acta	PROPN
admet-376	414	26	1822	1822	NUM
admet-376	414	27	(	(	PUNCT
admet-376	414	28	2012	2012	NUM
admet-376	414	29	)	)	PUNCT
admet-376	414	30	784	784	NUM
admet-376	414	31	-	-	SYM
admet-376	414	32	793	793	NUM
admet-376	414	33	.	.	PUNCT
admet-376	415	1	[	[	X
admet-376	415	2	50	50	NUM
admet-376	415	3	]	]	PUNCT
admet-376	415	4	b.	b.	PROPN
admet-376	415	5	halliwell	halliwell	PROPN
admet-376	415	6	,	,	PUNCT
admet-376	415	7	i.k	i.k	PROPN
admet-376	415	8	.	.	PROPN
admet-376	415	9	cheah	cheah	PROPN
admet-376	415	10	,	,	PUNCT
admet-376	415	11	c.l	c.l	PROPN
admet-376	415	12	.	.	PROPN
admet-376	415	13	drum	drum	PROPN
admet-376	415	14	.	.	PUNCT
admet-376	415	15	ergothioneine	ergothioneine	NOUN
admet-376	415	16	,	,	PUNCT
admet-376	415	17	an	an	DET
admet-376	415	18	adaptive	adaptive	ADJ
admet-376	415	19	antioxidant	antioxidant	NOUN
admet-376	415	20	for	for	ADP
admet-376	415	21	the	the	DET
admet-376	415	22	protection	protection	NOUN
admet-376	415	23	of	of	ADP
admet-376	415	24	injured	injured	ADJ
admet-376	415	25	tissues	tissue	NOUN
admet-376	415	26	?	?	PUNCT
admet-376	416	1	a	a	DET
admet-376	416	2	hypothesis	hypothesis	NOUN
admet-376	416	3	,	,	PUNCT
admet-376	416	4	biochem	biochem	PROPN
admet-376	416	5	biophys	biophy	NOUN
admet-376	416	6	res	re	NOUN
admet-376	416	7	commun	commun	PROPN
admet-376	416	8	470	470	NUM
admet-376	416	9	(	(	PUNCT
admet-376	416	10	2016	2016	NUM
admet-376	416	11	)	)	PUNCT
admet-376	416	12	245	245	NUM
admet-376	416	13	-	-	SYM
admet-376	416	14	250	250	NUM
admet-376	416	15	.	.	PUNCT
admet-376	417	1	[	[	X
admet-376	417	2	51	51	NUM
admet-376	417	3	]	]	SYM
admet-376	417	4	c.d	c.d	PROPN
admet-376	417	5	.	.	PROPN
admet-376	417	6	den	den	PROPN
admet-376	417	7	hengst	hengst	PROPN
admet-376	417	8	,	,	PUNCT
admet-376	417	9	m.j	m.j	PROPN
admet-376	417	10	.	.	PROPN
admet-376	417	11	buttner	buttner	PROPN
admet-376	417	12	.	.	PUNCT
admet-376	418	1	redox	redox	ADJ
admet-376	418	2	control	control	NOUN
admet-376	418	3	in	in	ADP
admet-376	418	4	actinobacteria	actinobacteria	NOUN
admet-376	418	5	,	,	PUNCT
admet-376	418	6	biochim	biochim	PROPN
admet-376	418	7	biophys	biophy	NOUN
admet-376	418	8	acta	acta	PROPN
admet-376	418	9	1780	1780	NUM
admet-376	418	10	(	(	PUNCT
admet-376	418	11	2008	2008	NUM
admet-376	418	12	)	)	PUNCT
admet-376	418	13	1201	1201	NUM
admet-376	418	14	-	-	SYM
admet-376	418	15	1216	1216	NUM
admet-376	418	16	.	.	PUNCT
admet-376	419	1	[	[	X
admet-376	419	2	52	52	NUM
admet-376	419	3	]	]	X
admet-376	419	4	i.k	i.k	PROPN
admet-376	419	5	.	.	PROPN
admet-376	419	6	cheah	cheah	PROPN
admet-376	419	7	,	,	PUNCT
admet-376	419	8	r.m.y	r.m.y	PROPN
admet-376	419	9	.	.	PROPN
admet-376	419	10	tang	tang	PROPN
admet-376	419	11	,	,	PUNCT
admet-376	419	12	t.s.z	t.s.z	PROPN
admet-376	419	13	.	.	PROPN
admet-376	419	14	yew	yew	PROPN
admet-376	419	15	,	,	PUNCT
admet-376	419	16	k.h.c	k.h.c	PROPN
admet-376	419	17	.	.	PUNCT
admet-376	420	1	lim	lim	PROPN
admet-376	420	2	,	,	PUNCT
admet-376	420	3	b.	b.	PROPN
admet-376	420	4	halliwell	halliwell	PROPN
admet-376	420	5	.	.	PUNCT
admet-376	421	1	administration	administration	NOUN
admet-376	421	2	of	of	ADP
admet-376	421	3	pure	pure	ADJ
admet-376	421	4	ergothioneine	ergothioneine	NOUN
admet-376	421	5	to	to	PART
admet-376	421	6	healthy	healthy	ADJ
admet-376	421	7	human	human	ADJ
admet-376	421	8	subjects	subject	NOUN
admet-376	421	9	:	:	PUNCT
admet-376	421	10	uptake	uptake	ADJ
admet-376	421	11	,	,	PUNCT
admet-376	421	12	metabolism	metabolism	NOUN
admet-376	421	13	,	,	PUNCT
admet-376	421	14	and	and	CCONJ
admet-376	421	15	effects	effect	NOUN
admet-376	421	16	on	on	ADP
admet-376	421	17	biomarkers	biomarker	NOUN
admet-376	421	18	of	of	ADP
admet-376	421	19	oxidative	oxidative	ADJ
admet-376	421	20	damage	damage	NOUN
admet-376	421	21	and	and	CCONJ
admet-376	421	22	inflammation	inflammation	NOUN
admet-376	421	23	,	,	PUNCT
admet-376	421	24	antioxid	antioxid	VERB
admet-376	421	25	redox	redox	NOUN
admet-376	421	26	signal	signal	NOUN
admet-376	421	27	26	26	NUM
admet-376	421	28	(	(	PUNCT
admet-376	421	29	2017	2017	NUM
admet-376	421	30	)	)	PUNCT
admet-376	421	31	193	193	NUM
admet-376	421	32	-	-	SYM
admet-376	421	33	206	206	NUM
admet-376	421	34	.	.	PUNCT
admet-376	422	1	[	[	X
admet-376	422	2	53	53	NUM
admet-376	422	3	]	]	PUNCT
admet-376	422	4	d.	d.	PROPN
admet-376	422	5	akanmu	akanmu	PROPN
admet-376	422	6	,	,	PUNCT
admet-376	422	7	r.	r.	PROPN
admet-376	422	8	cecchini	cecchini	PROPN
admet-376	422	9	,	,	PUNCT
admet-376	422	10	o.i	o.i	PROPN
admet-376	422	11	.	.	PROPN
admet-376	422	12	aruoma	aruoma	PROPN
admet-376	422	13	,	,	PUNCT
admet-376	422	14	b.	b.	PROPN
admet-376	422	15	halliwell	halliwell	PROPN
admet-376	422	16	.	.	PUNCT
admet-376	423	1	the	the	DET
admet-376	423	2	antioxidant	antioxidant	ADJ
admet-376	423	3	action	action	NOUN
admet-376	423	4	of	of	ADP
admet-376	423	5	ergothioneine	ergothioneine	NOUN
admet-376	423	6	,	,	PUNCT
admet-376	423	7	arch	arch	ADJ
admet-376	423	8	biochem	biochem	NOUN
admet-376	423	9	biophys	biophy	VERB
admet-376	423	10	288	288	NUM
admet-376	423	11	(	(	PUNCT
admet-376	423	12	1991	1991	NUM
admet-376	423	13	)	)	PUNCT
admet-376	423	14	10	10	NUM
admet-376	423	15	-	-	SYM
admet-376	423	16	16	16	NUM
admet-376	423	17	.	.	PUNCT
admet-376	424	1	[	[	X
admet-376	424	2	54	54	NUM
admet-376	424	3	]	]	X
admet-376	424	4	o.i	o.i	PROPN
admet-376	424	5	.	.	PROPN
admet-376	424	6	aruoma	aruoma	PROPN
admet-376	424	7	,	,	PUNCT
admet-376	424	8	m.	m.	NOUN
admet-376	424	9	whiteman	whiteman	PROPN
admet-376	424	10	,	,	PUNCT
admet-376	424	11	t.g	t.g	PROPN
admet-376	424	12	.	.	PROPN
admet-376	424	13	england	england	PROPN
admet-376	424	14	,	,	PUNCT
admet-376	424	15	b.	b.	PROPN
admet-376	424	16	halliwell	halliwell	PROPN
admet-376	424	17	.	.	PUNCT
admet-376	425	1	antioxidant	antioxidant	ADJ
admet-376	425	2	action	action	NOUN
admet-376	425	3	of	of	ADP
admet-376	425	4	ergothioneine	ergothioneine	NOUN
admet-376	425	5	:	:	PUNCT
admet-376	425	6	assessment	assessment	NOUN
admet-376	425	7	of	of	ADP
admet-376	425	8	its	its	PRON
admet-376	425	9	ability	ability	NOUN
admet-376	425	10	to	to	PART
admet-376	425	11	scavenge	scavenge	VERB
admet-376	425	12	peroxynitrite	peroxynitrite	ADJ
admet-376	425	13	,	,	PUNCT
admet-376	425	14	biochem	biochem	PROPN
admet-376	425	15	biophys	biophy	NOUN
admet-376	425	16	res	re	NOUN
admet-376	425	17	commun	commun	PROPN
admet-376	425	18	231	231	NUM
admet-376	425	19	(	(	PUNCT
admet-376	425	20	1997	1997	NUM
admet-376	425	21	)	)	PUNCT
admet-376	425	22	389391	389391	NUM
admet-376	425	23	.	.	PUNCT
admet-376	426	1	[	[	X
admet-376	426	2	55	55	NUM
admet-376	426	3	]	]	PUNCT
admet-376	426	4	t.	t.	PROPN
admet-376	426	5	asahi	asahi	PROPN
admet-376	426	6	,	,	PUNCT
admet-376	426	7	x.	x.	PROPN
admet-376	426	8	wu	wu	PROPN
admet-376	426	9	,	,	PUNCT
admet-376	426	10	h.	h.	PROPN
admet-376	426	11	shimoda	shimoda	PROPN
admet-376	426	12	,	,	PUNCT
admet-376	426	13	s.	s.	PROPN
admet-376	426	14	hisaka	hisaka	PROPN
admet-376	426	15	,	,	PUNCT
admet-376	426	16	e.	e.	PROPN
admet-376	426	17	harada	harada	PROPN
admet-376	426	18	,	,	PUNCT
admet-376	426	19	t.	t.	PROPN
admet-376	426	20	kanno	kanno	PROPN
admet-376	426	21	,	,	PUNCT
admet-376	426	22	y.	y.	PROPN
admet-376	426	23	nakamura	nakamura	PROPN
admet-376	426	24	,	,	PUNCT
admet-376	426	25	y.	y.	PROPN
admet-376	426	26	kato	kato	PROPN
admet-376	426	27	,	,	PUNCT
admet-376	426	28	t.	t.	PROPN
admet-376	426	29	osawa	osawa	PROPN
admet-376	426	30	.	.	PUNCT
admet-376	427	1	a	a	DET
admet-376	427	2	mushroom	mushroom	NOUN
admet-376	427	3	-	-	PUNCT
admet-376	427	4	derived	derive	VERB
admet-376	427	5	amino	amino	NOUN
admet-376	427	6	acid	acid	NOUN
admet-376	427	7	,	,	PUNCT
admet-376	427	8	ergothioneine	ergothioneine	NOUN
admet-376	427	9	,	,	PUNCT
admet-376	427	10	is	be	AUX
admet-376	427	11	a	a	DET
admet-376	427	12	potential	potential	ADJ
admet-376	427	13	inhibitor	inhibitor	NOUN
admet-376	427	14	of	of	ADP
admet-376	427	15	inflammation	inflammation	NOUN
admet-376	427	16	-	-	PUNCT
admet-376	427	17	related	relate	VERB
admet-376	427	18	dna	dna	NOUN
admet-376	427	19	halogenation	halogenation	NOUN
admet-376	427	20	,	,	PUNCT
admet-376	427	21	biosci	biosci	PROPN
admet-376	427	22	biotechnol	biotechnol	PROPN
admet-376	427	23	biochem	biochem	NOUN
admet-376	427	24	80	80	NUM
admet-376	427	25	(	(	PUNCT
admet-376	427	26	2016	2016	NUM
admet-376	427	27	)	)	PUNCT
admet-376	427	28	313	313	NUM
admet-376	427	29	-	-	SYM
admet-376	427	30	317	317	NUM
admet-376	427	31	.	.	PUNCT
admet-376	428	1	[	[	X
admet-376	428	2	56	56	NUM
admet-376	428	3	]	]	X
admet-376	428	4	a.j	a.j	PROPN
admet-376	428	5	.	.	PROPN
admet-376	428	6	weigand	weigand	PROPN
admet-376	428	7	-	-	PUNCT
admet-376	428	8	heller	heller	NOUN
admet-376	428	9	,	,	PUNCT
admet-376	428	10	p.m.	p.m.	NOUN
admet-376	428	11	kris	kris	PROPN
admet-376	428	12	-	-	PUNCT
admet-376	428	13	etherton	etherton	PROPN
admet-376	428	14	,	,	PUNCT
admet-376	428	15	r.b	r.b	PROPN
admet-376	428	16	.	.	PROPN
admet-376	428	17	beelman	beelman	PROPN
admet-376	428	18	.	.	PUNCT
admet-376	429	1	the	the	DET
admet-376	429	2	bioavailability	bioavailability	NOUN
admet-376	429	3	of	of	ADP
admet-376	429	4	ergothioneine	ergothioneine	NOUN
admet-376	429	5	from	from	ADP
admet-376	429	6	mushrooms	mushroom	NOUN
admet-376	429	7	(	(	PUNCT
admet-376	429	8	agaricus	agaricus	NOUN
admet-376	429	9	bisporus	bisporus	NOUN
admet-376	429	10	)	)	PUNCT
admet-376	429	11	and	and	CCONJ
admet-376	429	12	the	the	DET
admet-376	429	13	acute	acute	ADJ
admet-376	429	14	effects	effect	NOUN
admet-376	429	15	on	on	ADP
admet-376	429	16	antioxidant	antioxidant	ADJ
admet-376	429	17	capacity	capacity	NOUN
admet-376	429	18	and	and	CCONJ
admet-376	429	19	biomarkers	biomarker	NOUN
admet-376	429	20	of	of	ADP
admet-376	429	21	inflammation	inflammation	NOUN
admet-376	429	22	,	,	PUNCT
admet-376	429	23	prev	prev	X
admet-376	429	24	med	me	VERB
admet-376	429	25	54	54	NUM
admet-376	429	26	suppl	suppl	ADJ
admet-376	429	27	(	(	PUNCT
admet-376	429	28	2012	2012	NUM
admet-376	429	29	)	)	PUNCT
admet-376	429	30	s75	s75	NOUN
admet-376	429	31	-	-	PUNCT
admet-376	429	32	78	78	NUM
admet-376	429	33	.	.	PUNCT
admet-376	430	1	[	[	X
admet-376	430	2	57	57	NUM
admet-376	430	3	]	]	X
admet-376	430	4	i.k	i.k	PROPN
admet-376	430	5	.	.	PROPN
admet-376	430	6	cheah	cheah	PROPN
admet-376	430	7	,	,	PUNCT
admet-376	430	8	r.	r.	PROPN
admet-376	430	9	tang	tang	PROPN
admet-376	430	10	,	,	PUNCT
admet-376	430	11	p.	p.	NOUN
admet-376	430	12	ye	ye	NOUN
admet-376	430	13	,	,	PUNCT
admet-376	430	14	t.s	t.s	PROPN
admet-376	430	15	.	.	PROPN
admet-376	430	16	yew	yew	PROPN
admet-376	430	17	,	,	PUNCT
admet-376	430	18	k.h	k.h	PROPN
admet-376	430	19	.	.	PROPN
admet-376	430	20	lim	lim	PROPN
admet-376	430	21	,	,	PUNCT
admet-376	430	22	b.	b.	PROPN
admet-376	430	23	halliwell	halliwell	PROPN
admet-376	430	24	.	.	PUNCT
admet-376	431	1	liver	liver	NOUN
admet-376	431	2	ergothioneine	ergothioneine	NOUN
admet-376	431	3	accumulation	accumulation	NOUN
admet-376	431	4	in	in	ADP
admet-376	431	5	a	a	DET
admet-376	431	6	guinea	guinea	NOUN
admet-376	431	7	pig	pig	NOUN
admet-376	431	8	model	model	NOUN
admet-376	431	9	of	of	ADP
admet-376	431	10	non	non	ADJ
admet-376	431	11	-	-	ADJ
admet-376	431	12	alcoholic	alcoholic	ADJ
admet-376	431	13	fatty	fatty	NOUN
admet-376	431	14	liver	liver	NOUN
admet-376	431	15	disease	disease	NOUN
admet-376	431	16	.	.	PUNCT
admet-376	432	1	a	a	DET
admet-376	432	2	possible	possible	ADJ
admet-376	432	3	mechanism	mechanism	NOUN
admet-376	432	4	of	of	ADP
admet-376	432	5	defence	defence	NOUN
admet-376	432	6	?	?	PUNCT
admet-376	432	7	,	,	PUNCT
admet-376	432	8	free	free	ADJ
admet-376	432	9	radic	radic	NOUN
admet-376	432	10	res	re	VERB
admet-376	432	11	50	50	NUM
admet-376	432	12	(	(	PUNCT
admet-376	432	13	2016	2016	NUM
admet-376	432	14	)	)	PUNCT
admet-376	432	15	14	14	NUM
admet-376	432	16	-	-	SYM
admet-376	432	17	25	25	NUM
admet-376	432	18	.	.	PUNCT
admet-376	433	1	[	[	X
admet-376	433	2	58	58	NUM
admet-376	433	3	]	]	X
admet-376	433	4	n.	n.	PROPN
admet-376	433	5	d'onofrio	d'onofrio	PROPN
admet-376	433	6	,	,	PUNCT
admet-376	433	7	l.	l.	PROPN
admet-376	433	8	servillo	servillo	PROPN
admet-376	433	9	,	,	PUNCT
admet-376	433	10	a.	a.	NOUN
admet-376	433	11	giovane	giovane	PROPN
admet-376	433	12	,	,	PUNCT
admet-376	433	13	r.	r.	PROPN
admet-376	433	14	casale	casale	PROPN
admet-376	433	15	,	,	PUNCT
admet-376	433	16	m.	m.	NOUN
admet-376	433	17	vitiello	vitiello	PROPN
admet-376	433	18	,	,	PUNCT
admet-376	433	19	r.	r.	PROPN
admet-376	433	20	marfella	marfella	PROPN
admet-376	433	21	,	,	PUNCT
admet-376	433	22	g.	g.	PROPN
admet-376	433	23	paolisso	paolisso	PROPN
admet-376	433	24	,	,	PUNCT
admet-376	433	25	m.l	m.l	PROPN
admet-376	433	26	.	.	PROPN
admet-376	433	27	balestrieri	balestrieri	PROPN
admet-376	433	28	.	.	PUNCT
admet-376	434	1	ergothioneine	ergothioneine	PROPN
admet-376	434	2	oxidation	oxidation	NOUN
admet-376	434	3	in	in	ADP
admet-376	434	4	the	the	DET
admet-376	434	5	protection	protection	NOUN
admet-376	434	6	against	against	ADP
admet-376	434	7	high	high	ADJ
admet-376	434	8	-	-	PUNCT
admet-376	434	9	glucose	glucose	NOUN
admet-376	434	10	induced	induce	VERB
admet-376	434	11	endothelial	endothelial	ADJ
admet-376	434	12	senescence	senescence	NOUN
admet-376	434	13	:	:	PUNCT
admet-376	434	14	involvement	involvement	NOUN
admet-376	434	15	of	of	ADP
admet-376	434	16	sirt1	sirt1	NOUN
admet-376	434	17	and	and	CCONJ
admet-376	434	18	sirt6	sirt6	NOUN
admet-376	434	19	,	,	PUNCT
admet-376	434	20	free	free	ADJ
admet-376	434	21	radic	radic	ADJ
admet-376	434	22	biol	biol	NOUN
admet-376	434	23	med	me	VERB
admet-376	434	24	96	96	NUM
admet-376	434	25	(	(	PUNCT
admet-376	434	26	2016	2016	NUM
admet-376	434	27	)	)	PUNCT
admet-376	434	28	211	211	NUM
admet-376	434	29	-	-	SYM
admet-376	434	30	222	222	NUM
admet-376	434	31	.	.	PUNCT
admet-376	435	1	[	[	X
admet-376	435	2	59	59	NUM
admet-376	435	3	]	]	SYM
admet-376	435	4	i.k	i.k	PROPN
admet-376	435	5	.	.	PROPN
admet-376	435	6	cheah	cheah	PROPN
admet-376	435	7	,	,	PUNCT
admet-376	435	8	r.l	r.l	PROPN
admet-376	435	9	.	.	PROPN
admet-376	435	10	ong	ong	PROPN
admet-376	435	11	,	,	PUNCT
admet-376	435	12	j.	j.	PROPN
admet-376	435	13	gruber	gruber	PROPN
admet-376	435	14	,	,	PUNCT
admet-376	435	15	t.s	t.s	PROPN
admet-376	435	16	.	.	PROPN
admet-376	435	17	yew	yew	PROPN
admet-376	435	18	,	,	PUNCT
admet-376	435	19	l.f	l.f	PROPN
admet-376	435	20	.	.	PROPN
admet-376	435	21	ng	ng	PROPN
admet-376	435	22	,	,	PUNCT
admet-376	435	23	c.b	c.b	PROPN
admet-376	435	24	.	.	PROPN
admet-376	435	25	chen	chen	PROPN
admet-376	435	26	,	,	PUNCT
admet-376	435	27	b.	b.	PROPN
admet-376	435	28	halliwell	halliwell	PROPN
admet-376	435	29	.	.	PUNCT
admet-376	436	1	knockout	knockout	NOUN
admet-376	436	2	of	of	ADP
admet-376	436	3	a	a	DET
admet-376	436	4	putative	putative	ADJ
admet-376	436	5	ergothioneine	ergothioneine	NOUN
admet-376	436	6	transporter	transporter	NOUN
admet-376	436	7	in	in	ADP
admet-376	436	8	caenorhabditis	caenorhabditis	ADJ
admet-376	436	9	elegans	elegan	NOUN
admet-376	436	10	decreases	decrease	VERB
admet-376	436	11	lifespan	lifespan	ADJ
admet-376	436	12	and	and	CCONJ
admet-376	436	13	increases	increase	VERB
admet-376	436	14	susceptibility	susceptibility	NOUN
admet-376	436	15	to	to	PART
admet-376	436	16	oxidative	oxidative	ADJ
admet-376	436	17	damage	damage	NOUN
admet-376	436	18	,	,	PUNCT
admet-376	436	19	free	free	ADJ
admet-376	436	20	radic	radic	NOUN
admet-376	436	21	res	re	VERB
admet-376	436	22	47	47	NUM
admet-376	436	23	(	(	PUNCT
admet-376	436	24	2013	2013	NUM
admet-376	436	25	)	)	PUNCT
admet-376	436	26	1036	1036	NUM
admet-376	436	27	-	-	SYM
admet-376	436	28	1045	1045	NUM
admet-376	436	29	.	.	PUNCT
admet-376	437	1	[	[	X
admet-376	437	2	60	60	NUM
admet-376	437	3	]	]	X
admet-376	437	4	o.i	o.i	PROPN
admet-376	437	5	.	.	PROPN
admet-376	437	6	aruoma	aruoma	PROPN
admet-376	437	7	,	,	PUNCT
admet-376	437	8	j.p.e	j.p.e	PROPN
admet-376	437	9	.	.	PROPN
admet-376	437	10	spencer	spencer	PROPN
admet-376	437	11	,	,	PUNCT
admet-376	437	12	n.	n.	PROPN
admet-376	437	13	mahmood	mahmood	PROPN
admet-376	437	14	.	.	PUNCT
admet-376	438	1	protection	protection	NOUN
admet-376	438	2	against	against	ADP
admet-376	438	3	oxidative	oxidative	ADJ
admet-376	438	4	damage	damage	NOUN
admet-376	438	5	and	and	CCONJ
admet-376	438	6	cell	cell	NOUN
admet-376	438	7	death	death	NOUN
admet-376	438	8	by	by	ADP
admet-376	438	9	the	the	DET
admet-376	438	10	natural	natural	ADJ
admet-376	438	11	antioxidant	antioxidant	NOUN
admet-376	438	12	ergothioneine	ergothioneine	NOUN
admet-376	438	13	,	,	PUNCT
admet-376	438	14	food	food	NOUN
admet-376	438	15	chem	chem	NOUN
admet-376	438	16	toxicol	toxicol	PROPN
admet-376	438	17	37	37	NUM
admet-376	438	18	(	(	PUNCT
admet-376	438	19	1999	1999	NUM
admet-376	438	20	)	)	PUNCT
admet-376	438	21	1043	1043	NUM
admet-376	438	22	-	-	SYM
admet-376	438	23	1053	1053	NUM
admet-376	438	24	.	.	PUNCT
admet-376	439	1	[	[	X
admet-376	439	2	61	61	NUM
admet-376	439	3	]	]	X
admet-376	439	4	j.h	j.h	PROPN
admet-376	439	5	.	.	PROPN
admet-376	439	6	jang	jang	PROPN
admet-376	439	7	,	,	PUNCT
admet-376	439	8	o.i	o.i	PROPN
admet-376	439	9	.	.	PROPN
admet-376	439	10	aruoma	aruoma	PROPN
admet-376	439	11	,	,	PUNCT
admet-376	439	12	l.s	l.s	PROPN
admet-376	439	13	.	.	PROPN
admet-376	439	14	jen	jen	PROPN
admet-376	439	15	,	,	PUNCT
admet-376	439	16	h.y	h.y	PROPN
admet-376	439	17	.	.	PROPN
admet-376	439	18	chung	chung	PROPN
admet-376	439	19	,	,	PUNCT
admet-376	439	20	y.j	y.j	PROPN
admet-376	439	21	.	.	PROPN
admet-376	439	22	surh	surh	PROPN
admet-376	439	23	.	.	PUNCT
admet-376	440	1	ergothioneine	ergothioneine	NOUN
admet-376	440	2	rescues	rescue	VERB
admet-376	440	3	pc12	pc12	PROPN
admet-376	440	4	cells	cell	NOUN
admet-376	440	5	from	from	ADP
admet-376	440	6	betaamyloid	betaamyloid	NOUN
admet-376	440	7	-	-	PUNCT
admet-376	440	8	induced	induce	VERB
admet-376	440	9	apoptotic	apoptotic	ADJ
admet-376	440	10	death	death	NOUN
admet-376	440	11	,	,	PUNCT
admet-376	440	12	free	free	ADJ
admet-376	440	13	radic	radic	ADJ
admet-376	440	14	biol	biol	PROPN
admet-376	440	15	med	me	VERB
admet-376	440	16	36	36	NUM
admet-376	440	17	(	(	PUNCT
admet-376	440	18	2004	2004	NUM
admet-376	440	19	)	)	PUNCT
admet-376	440	20	288	288	NUM
admet-376	440	21	-	-	SYM
admet-376	440	22	299	299	NUM
admet-376	440	23	.	.	PUNCT
admet-376	441	1	admet	admet	PROPN
admet-376	441	2	&	&	CCONJ
admet-376	441	3	dmpk	dmpk	PROPN
admet-376	441	4	5(2	5(2	NUM
admet-376	441	5	)	)	PUNCT
admet-376	441	6	(	(	PUNCT
admet-376	441	7	2017	2017	NUM
admet-376	441	8	)	)	PUNCT
admet-376	441	9	85	85	NUM
admet-376	441	10	-	-	SYM
admet-376	441	11	125	125	NUM
admet-376	441	12	exogenous	exogenous	ADJ
admet-376	441	13	natural	natural	ADJ
admet-376	441	14	products	product	NOUN
admet-376	441	15	as	as	ADP
admet-376	441	16	‘	'	PUNCT
admet-376	441	17	natural	natural	ADJ
admet-376	441	18	’	'	PUNCT
admet-376	441	19	drug	drug	NOUN
admet-376	441	20	transporter	transporter	NOUN
admet-376	441	21	substrates	substrate	VERB
admet-376	441	22	doi	doi	NOUN
admet-376	441	23	:	:	PUNCT
admet-376	441	24	10.5599	10.5599	NUM
admet-376	441	25	/	/	SYM
admet-376	441	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	441	27	117	117	NUM
admet-376	441	28	[	[	X
admet-376	441	29	62	62	NUM
admet-376	441	30	]	]	X
admet-376	441	31	j.e	j.e	PROPN
admet-376	441	32	.	.	PROPN
admet-376	441	33	repine	repine	PROPN
admet-376	441	34	,	,	PUNCT
admet-376	441	35	n.d	n.d	PROPN
admet-376	441	36	.	.	PROPN
admet-376	441	37	elkins	elkins	PROPN
admet-376	441	38	.	.	PUNCT
admet-376	442	1	effect	effect	NOUN
admet-376	442	2	of	of	ADP
admet-376	442	3	ergothioneine	ergothioneine	NOUN
admet-376	442	4	on	on	ADP
admet-376	442	5	acute	acute	ADJ
admet-376	442	6	lung	lung	NOUN
admet-376	442	7	injury	injury	NOUN
admet-376	442	8	and	and	CCONJ
admet-376	442	9	inflammation	inflammation	NOUN
admet-376	442	10	in	in	ADP
admet-376	442	11	cytokine	cytokine	NOUN
admet-376	442	12	insufflated	insufflate	VERB
admet-376	442	13	rats	rat	NOUN
admet-376	442	14	,	,	PUNCT
admet-376	442	15	prev	prev	X
admet-376	442	16	med	me	VERB
admet-376	442	17	54	54	NUM
admet-376	442	18	suppl	suppl	ADJ
admet-376	442	19	(	(	PUNCT
admet-376	442	20	2012	2012	NUM
admet-376	442	21	)	)	PUNCT
admet-376	442	22	s79	s79	NOUN
admet-376	442	23	-	-	PUNCT
admet-376	442	24	82	82	NUM
admet-376	442	25	.	.	PUNCT
admet-376	443	1	[	[	X
admet-376	443	2	63	63	NUM
admet-376	443	3	]	]	X
admet-376	443	4	k.j	k.j	PROPN
admet-376	443	5	.	.	PROPN
admet-376	443	6	sheridan	sheridan	PROPN
admet-376	443	7	,	,	PUNCT
admet-376	443	8	b.e	b.e	PROPN
admet-376	443	9	.	.	PROPN
admet-376	443	10	lechner	lechner	PROPN
admet-376	443	11	,	,	PUNCT
admet-376	443	12	g.o	g.o	PROPN
admet-376	443	13	.	.	PROPN
admet-376	443	14	keeffe	keeffe	PROPN
admet-376	443	15	,	,	PUNCT
admet-376	443	16	m.a	m.a	PROPN
admet-376	443	17	.	.	PROPN
admet-376	443	18	keller	keller	PROPN
admet-376	443	19	,	,	PUNCT
admet-376	443	20	e.r	e.r	PROPN
admet-376	443	21	.	.	PROPN
admet-376	443	22	werner	werner	PROPN
admet-376	443	23	,	,	PUNCT
admet-376	443	24	h.	h.	PROPN
admet-376	443	25	lindner	lindner	PROPN
admet-376	443	26	,	,	PUNCT
admet-376	443	27	g.w	g.w	PROPN
admet-376	443	28	.	.	PROPN
admet-376	443	29	jones	jones	PROPN
admet-376	443	30	,	,	PUNCT
admet-376	443	31	h.	h.	PROPN
admet-376	443	32	haas	haas	PROPN
admet-376	443	33	,	,	PUNCT
admet-376	443	34	s.	s.	PROPN
admet-376	443	35	doyle	doyle	PROPN
admet-376	443	36	.	.	PUNCT
admet-376	443	37	ergothioneine	ergothioneine	PROPN
admet-376	443	38	biosynthesis	biosynthesis	NOUN
admet-376	443	39	and	and	CCONJ
admet-376	443	40	functionality	functionality	NOUN
admet-376	443	41	in	in	ADP
admet-376	443	42	the	the	DET
admet-376	443	43	opportunistic	opportunistic	ADJ
admet-376	443	44	fungal	fungal	ADJ
admet-376	443	45	pathogen	pathogen	NOUN
admet-376	443	46	,	,	PUNCT
admet-376	443	47	aspergillus	aspergillus	NOUN
admet-376	443	48	fumigatus	fumigatus	NOUN
admet-376	443	49	,	,	PUNCT
admet-376	443	50	sci	sci	PROPN
admet-376	443	51	rep	rep	PROPN
admet-376	443	52	6	6	NUM
admet-376	443	53	(	(	PUNCT
admet-376	443	54	2016	2016	NUM
admet-376	443	55	)	)	PUNCT
admet-376	443	56	35306	35306	NUM
admet-376	443	57	.	.	PUNCT
admet-376	444	1	[	[	X
admet-376	444	2	64	64	NUM
admet-376	444	3	]	]	X
admet-376	444	4	k.m	k.m	PROPN
admet-376	444	5	.	.	PROPN
admet-376	444	6	alamgir	alamgir	PROPN
admet-376	444	7	,	,	PUNCT
admet-376	444	8	s.	s.	PROPN
admet-376	444	9	masuda	masuda	PROPN
admet-376	444	10	,	,	PUNCT
admet-376	444	11	y.	y.	PROPN
admet-376	444	12	fujitani	fujitani	PROPN
admet-376	444	13	,	,	PUNCT
admet-376	444	14	f.	f.	PROPN
admet-376	444	15	fukuda	fukuda	PROPN
admet-376	444	16	,	,	PUNCT
admet-376	444	17	a.	a.	NOUN
admet-376	444	18	tani	tani	PROPN
admet-376	444	19	.	.	PUNCT
admet-376	445	1	production	production	NOUN
admet-376	445	2	of	of	ADP
admet-376	445	3	ergothioneine	ergothioneine	NOUN
admet-376	445	4	by	by	ADP
admet-376	445	5	methylobacterium	methylobacterium	NOUN
admet-376	445	6	species	specie	NOUN
admet-376	445	7	,	,	PUNCT
admet-376	445	8	front	front	ADJ
admet-376	445	9	microbiol	microbiol	NOUN
admet-376	445	10	6	6	NUM
admet-376	445	11	(	(	PUNCT
admet-376	445	12	2015	2015	NUM
admet-376	445	13	)	)	PUNCT
admet-376	445	14	1185	1185	NUM
admet-376	445	15	.	.	PUNCT
admet-376	446	1	[	[	X
admet-376	446	2	65	65	NUM
admet-376	446	3	]	]	X
admet-376	446	4	d.	d.	PROPN
admet-376	446	5	gründemann	gründemann	PROPN
admet-376	446	6	,	,	PUNCT
admet-376	446	7	s.	s.	PROPN
admet-376	446	8	harlfinger	harlfinger	PROPN
admet-376	446	9	,	,	PUNCT
admet-376	446	10	s.	s.	PROPN
admet-376	446	11	golz	golz	PROPN
admet-376	446	12	,	,	PUNCT
admet-376	446	13	a.	a.	NOUN
admet-376	446	14	geerts	geerts	PROPN
admet-376	446	15	,	,	PUNCT
admet-376	446	16	a.	a.	PROPN
admet-376	446	17	lazar	lazar	PROPN
admet-376	446	18	,	,	PUNCT
admet-376	446	19	r.	r.	PROPN
admet-376	446	20	berkels	berkels	PROPN
admet-376	446	21	,	,	PUNCT
admet-376	446	22	n.	n.	PROPN
admet-376	446	23	jung	jung	PROPN
admet-376	446	24	,	,	PUNCT
admet-376	446	25	a.	a.	NOUN
admet-376	446	26	rubbert	rubbert	PROPN
admet-376	446	27	,	,	PUNCT
admet-376	446	28	e.	e.	PROPN
admet-376	446	29	schömig	schömig	PROPN
admet-376	446	30	.	.	PUNCT
admet-376	447	1	discovery	discovery	NOUN
admet-376	447	2	of	of	ADP
admet-376	447	3	the	the	DET
admet-376	447	4	ergothioneine	ergothioneine	NOUN
admet-376	447	5	transporter	transporter	NOUN
admet-376	447	6	,	,	PUNCT
admet-376	447	7	proc	proc	PROPN
admet-376	447	8	natl	natl	PROPN
admet-376	447	9	acad	acad	PROPN
admet-376	447	10	sci	sci	PROPN
admet-376	447	11	u	u	PROPN
admet-376	447	12	s	s	PROPN
admet-376	447	13	a	a	DET
admet-376	447	14	102	102	NUM
admet-376	447	15	(	(	PUNCT
admet-376	447	16	2005	2005	NUM
admet-376	447	17	)	)	PUNCT
admet-376	447	18	5256	5256	NUM
admet-376	447	19	-	-	SYM
admet-376	447	20	5261	5261	NUM
admet-376	447	21	.	.	PUNCT
admet-376	448	1	[	[	X
admet-376	448	2	66	66	NUM
admet-376	448	3	]	]	X
admet-376	448	4	d.	d.	PROPN
admet-376	448	5	gründemann	gründemann	PROPN
admet-376	448	6	.	.	PUNCT
admet-376	449	1	the	the	DET
admet-376	449	2	ergothioneine	ergothioneine	NOUN
admet-376	449	3	transporter	transporter	NOUN
admet-376	449	4	controls	control	NOUN
admet-376	449	5	and	and	CCONJ
admet-376	449	6	indicates	indicate	VERB
admet-376	449	7	ergothioneine	ergothioneine	NOUN
admet-376	449	8	activity	activity	NOUN
admet-376	449	9	--	--	PUNCT
admet-376	449	10	a	a	DET
admet-376	449	11	review	review	NOUN
admet-376	449	12	,	,	PUNCT
admet-376	449	13	prev	prev	X
admet-376	449	14	med	me	VERB
admet-376	449	15	54	54	NUM
admet-376	449	16	suppl	suppl	ADJ
admet-376	449	17	(	(	PUNCT
admet-376	449	18	2012	2012	NUM
admet-376	449	19	)	)	PUNCT
admet-376	449	20	s71	s71	NOUN
admet-376	449	21	-	-	PUNCT
admet-376	449	22	74	74	NUM
admet-376	449	23	.	.	PUNCT
admet-376	450	1	[	[	X
admet-376	450	2	67	67	NUM
admet-376	450	3	]	]	PUNCT
admet-376	450	4	t.	t.	PROPN
admet-376	450	5	shimizu	shimizu	PROPN
admet-376	450	6	,	,	PUNCT
admet-376	450	7	y.	y.	PROPN
admet-376	450	8	masuo	masuo	PROPN
admet-376	450	9	,	,	PUNCT
admet-376	450	10	s.	s.	PROPN
admet-376	450	11	takahashi	takahashi	PROPN
admet-376	450	12	,	,	PUNCT
admet-376	450	13	n.	n.	PROPN
admet-376	450	14	nakamichi	nakamichi	PROPN
admet-376	450	15	,	,	PUNCT
admet-376	450	16	y.	y.	PROPN
admet-376	450	17	kato	kato	PROPN
admet-376	450	18	.	.	PUNCT
admet-376	451	1	organic	organic	ADJ
admet-376	451	2	cation	cation	NOUN
admet-376	451	3	transporter	transporter	NOUN
admet-376	451	4	octn1mediated	octn1mediate	VERB
admet-376	451	5	uptake	uptake	NOUN
admet-376	451	6	of	of	ADP
admet-376	451	7	food	food	NOUN
admet-376	451	8	-	-	PUNCT
admet-376	451	9	derived	derive	VERB
admet-376	451	10	antioxidant	antioxidant	NOUN
admet-376	451	11	ergothioneine	ergothioneine	NOUN
admet-376	451	12	into	into	ADP
admet-376	451	13	infiltrating	infiltrate	VERB
admet-376	451	14	macrophages	macrophage	NOUN
admet-376	451	15	during	during	ADP
admet-376	451	16	intestinal	intestinal	ADJ
admet-376	451	17	inflammation	inflammation	NOUN
admet-376	451	18	in	in	ADP
admet-376	451	19	mice	mouse	NOUN
admet-376	451	20	,	,	PUNCT
admet-376	451	21	drug	drug	NOUN
admet-376	451	22	metab	metab	NOUN
admet-376	451	23	pharmacokinet	pharmacokinet	NOUN
admet-376	451	24	30	30	NUM
admet-376	451	25	(	(	PUNCT
admet-376	451	26	2015	2015	NUM
admet-376	451	27	)	)	PUNCT
admet-376	451	28	231	231	NUM
admet-376	451	29	-	-	SYM
admet-376	451	30	239	239	NUM
admet-376	451	31	.	.	PUNCT
admet-376	452	1	[	[	X
admet-376	452	2	68	68	NUM
admet-376	452	3	]	]	X
admet-376	452	4	n.	n.	PROPN
admet-376	452	5	nakamichi	nakamichi	PROPN
admet-376	452	6	,	,	PUNCT
admet-376	452	7	h.	h.	PROPN
admet-376	452	8	shima	shima	PROPN
admet-376	452	9	,	,	PUNCT
admet-376	452	10	s.	s.	PROPN
admet-376	452	11	asano	asano	PROPN
admet-376	452	12	,	,	PUNCT
admet-376	452	13	t.	t.	NOUN
admet-376	452	14	ishimoto	ishimoto	NOUN
admet-376	452	15	,	,	PUNCT
admet-376	452	16	t.	t.	NOUN
admet-376	452	17	sugiura	sugiura	NOUN
admet-376	452	18	,	,	PUNCT
admet-376	452	19	k.	k.	PROPN
admet-376	452	20	matsubara	matsubara	PROPN
admet-376	452	21	,	,	PUNCT
admet-376	452	22	h.	h.	PROPN
admet-376	452	23	kusuhara	kusuhara	PROPN
admet-376	452	24	,	,	PUNCT
admet-376	452	25	y.	y.	PROPN
admet-376	452	26	sugiyama	sugiyama	PROPN
admet-376	452	27	,	,	PUNCT
admet-376	452	28	y.	y.	PROPN
admet-376	452	29	sai	sai	PROPN
admet-376	452	30	,	,	PUNCT
admet-376	452	31	k.	k.	PROPN
admet-376	452	32	miyamoto	miyamoto	PROPN
admet-376	452	33	,	,	PUNCT
admet-376	452	34	a.	a.	PROPN
admet-376	452	35	tsuji	tsuji	PROPN
admet-376	452	36	,	,	PUNCT
admet-376	452	37	y.	y.	PROPN
admet-376	452	38	kato	kato	PROPN
admet-376	452	39	.	.	PUNCT
admet-376	453	1	involvement	involvement	NOUN
admet-376	453	2	of	of	ADP
admet-376	453	3	carnitine	carnitine	NOUN
admet-376	453	4	/	/	SYM
admet-376	453	5	organic	organic	ADJ
admet-376	453	6	cation	cation	NOUN
admet-376	453	7	transporter	transporter	NOUN
admet-376	453	8	octn1	octn1	ADJ
admet-376	453	9	/	/	SYM
admet-376	453	10	slc22a4	slc22a4	NOUN
admet-376	453	11	in	in	ADP
admet-376	453	12	gastrointestinal	gastrointestinal	ADJ
admet-376	453	13	absorption	absorption	NOUN
admet-376	453	14	of	of	ADP
admet-376	453	15	metformin	metformin	PROPN
admet-376	453	16	,	,	PUNCT
admet-376	453	17	j	j	PROPN
admet-376	453	18	pharm	pharm	PROPN
admet-376	453	19	sci	sci	PROPN
admet-376	453	20	102	102	NUM
admet-376	453	21	(	(	PUNCT
admet-376	453	22	2013	2013	NUM
admet-376	453	23	)	)	PUNCT
admet-376	453	24	3407	3407	NUM
admet-376	453	25	-	-	SYM
admet-376	453	26	3417	3417	NUM
admet-376	453	27	.	.	PUNCT
admet-376	454	1	[	[	X
admet-376	454	2	69	69	NUM
admet-376	454	3	]	]	X
admet-376	454	4	m.a	m.a	PROPN
admet-376	454	5	.	.	PROPN
admet-376	454	6	hediger	hediger	PROPN
admet-376	454	7	,	,	PUNCT
admet-376	454	8	b.	b.	PROPN
admet-376	454	9	clemencon	clemencon	PROPN
admet-376	454	10	,	,	PUNCT
admet-376	454	11	r.e	r.e	PROPN
admet-376	454	12	.	.	PROPN
admet-376	454	13	burrier	burry	ADJ
admet-376	454	14	,	,	PUNCT
admet-376	454	15	e.a	e.a	PROPN
admet-376	454	16	.	.	PROPN
admet-376	454	17	bruford	bruford	PROPN
admet-376	454	18	.	.	PUNCT
admet-376	455	1	the	the	DET
admet-376	455	2	abcs	abc	NOUN
admet-376	455	3	of	of	ADP
admet-376	455	4	membrane	membrane	NOUN
admet-376	455	5	transporters	transporter	NOUN
admet-376	455	6	in	in	ADP
admet-376	455	7	health	health	NOUN
admet-376	455	8	and	and	CCONJ
admet-376	455	9	disease	disease	NOUN
admet-376	455	10	(	(	PUNCT
admet-376	455	11	slc	slc	PROPN
admet-376	455	12	series	series	PROPN
admet-376	455	13	):	):	PUNCT
admet-376	455	14	introduction	introduction	NOUN
admet-376	455	15	,	,	PUNCT
admet-376	455	16	mol	mol	ADP
admet-376	455	17	aspects	aspect	NOUN
admet-376	455	18	med	me	VERB
admet-376	455	19	34	34	NUM
admet-376	455	20	(	(	PUNCT
admet-376	455	21	2013	2013	NUM
admet-376	455	22	)	)	PUNCT
admet-376	455	23	95	95	NUM
admet-376	455	24	-	-	SYM
admet-376	455	25	107	107	NUM
admet-376	455	26	.	.	PUNCT
admet-376	456	1	[	[	X
admet-376	456	2	70	70	X
admet-376	456	3	]	]	X
admet-376	456	4	j.y	j.y	PROPN
admet-376	456	5	.	.	PROPN
admet-376	456	6	dai	dai	PROPN
admet-376	456	7	,	,	PUNCT
admet-376	456	8	j.l	j.l	PROPN
admet-376	456	9	.	.	PROPN
admet-376	456	10	yang	yang	PROPN
admet-376	456	11	,	,	PUNCT
admet-376	456	12	c.	c.	PROPN
admet-376	456	13	li	li	PROPN
admet-376	456	14	.	.	PROPN
admet-376	456	15	transport	transport	NOUN
admet-376	456	16	and	and	CCONJ
admet-376	456	17	metabolism	metabolism	NOUN
admet-376	456	18	of	of	ADP
admet-376	456	19	flavonoids	flavonoid	NOUN
admet-376	456	20	from	from	ADP
admet-376	456	21	chinese	chinese	ADJ
admet-376	456	22	herbal	herbal	ADJ
admet-376	456	23	remedy	remedy	NOUN
admet-376	456	24	xiaochaihutang	xiaochaihutang	PROPN
admet-376	456	25	across	across	ADP
admet-376	456	26	human	human	ADJ
admet-376	456	27	intestinal	intestinal	ADJ
admet-376	456	28	caco-2	caco-2	NUM
admet-376	456	29	cell	cell	NOUN
admet-376	456	30	monolayers	monolayer	NOUN
admet-376	456	31	,	,	PUNCT
admet-376	456	32	acta	acta	PROPN
admet-376	456	33	pharmacol	pharmacol	PROPN
admet-376	456	34	sin	sin	NOUN
admet-376	456	35	29	29	NUM
admet-376	456	36	(	(	PUNCT
admet-376	456	37	2008	2008	NUM
admet-376	456	38	)	)	PUNCT
admet-376	456	39	10861093	10861093	NUM
admet-376	456	40	.	.	PUNCT
admet-376	457	1	[	[	X
admet-376	457	2	71	71	NUM
admet-376	457	3	]	]	PUNCT
admet-376	457	4	a.	a.	NOUN
admet-376	457	5	maestro	maestro	NOUN
admet-376	457	6	,	,	PUNCT
admet-376	457	7	m.	m.	NOUN
admet-376	457	8	terdoslavich	terdoslavich	PROPN
admet-376	457	9	,	,	PUNCT
admet-376	457	10	a.	a.	NOUN
admet-376	457	11	vanzo	vanzo	PROPN
admet-376	457	12	,	,	PUNCT
admet-376	457	13	a.	a.	PROPN
admet-376	457	14	kuku	kuku	PROPN
admet-376	457	15	,	,	PUNCT
admet-376	457	16	f.	f.	PROPN
admet-376	457	17	tramer	tramer	PROPN
admet-376	457	18	,	,	PUNCT
admet-376	457	19	v.	v.	PROPN
admet-376	457	20	nicolin	nicolin	PROPN
admet-376	457	21	,	,	PUNCT
admet-376	457	22	f.	f.	PROPN
admet-376	457	23	micali	micali	PROPN
admet-376	457	24	,	,	PUNCT
admet-376	457	25	g.	g.	PROPN
admet-376	457	26	decorti	decorti	PROPN
admet-376	457	27	,	,	PUNCT
admet-376	457	28	s.	s.	PROPN
admet-376	457	29	passamonti	passamonti	PROPN
admet-376	457	30	.	.	PUNCT
admet-376	458	1	expression	expression	NOUN
admet-376	458	2	of	of	ADP
admet-376	458	3	bilitranslocase	bilitranslocase	NOUN
admet-376	458	4	in	in	ADP
admet-376	458	5	the	the	DET
admet-376	458	6	vascular	vascular	ADJ
admet-376	458	7	endothelium	endothelium	NOUN
admet-376	458	8	and	and	CCONJ
admet-376	458	9	its	its	PRON
admet-376	458	10	function	function	NOUN
admet-376	458	11	as	as	ADP
admet-376	458	12	a	a	DET
admet-376	458	13	flavonoid	flavonoid	NOUN
admet-376	458	14	transporter	transporter	NOUN
admet-376	458	15	,	,	PUNCT
admet-376	458	16	cardiovasc	cardiovasc	PROPN
admet-376	458	17	res	re	VERB
admet-376	458	18	85	85	NUM
admet-376	458	19	(	(	PUNCT
admet-376	458	20	2010	2010	NUM
admet-376	458	21	)	)	PUNCT
admet-376	458	22	175	175	NUM
admet-376	458	23	-	-	SYM
admet-376	458	24	183	183	NUM
admet-376	458	25	.	.	PUNCT
admet-376	459	1	[	[	X
admet-376	459	2	72	72	NUM
admet-376	459	3	]	]	X
admet-376	459	4	l.	l.	PROPN
admet-376	459	5	ziberna	ziberna	PROPN
admet-376	459	6	,	,	PUNCT
admet-376	459	7	s.	s.	PROPN
admet-376	459	8	fornasaro	fornasaro	PROPN
admet-376	459	9	,	,	PUNCT
admet-376	459	10	j.	j.	PROPN
admet-376	459	11	čvorović	čvorović	PROPN
admet-376	459	12	,	,	PUNCT
admet-376	459	13	f.	f.	PROPN
admet-376	459	14	tramer	tramer	PROPN
admet-376	459	15	,	,	PUNCT
admet-376	459	16	s.	s.	PROPN
admet-376	459	17	passamonti	passamonti	PROPN
admet-376	459	18	,	,	PUNCT
admet-376	459	19	bioavailability	bioavailability	NOUN
admet-376	459	20	of	of	ADP
admet-376	459	21	flavonoids	flavonoid	NOUN
admet-376	459	22	:	:	PUNCT
admet-376	459	23	the	the	DET
admet-376	459	24	role	role	NOUN
admet-376	459	25	of	of	ADP
admet-376	459	26	cell	cell	NOUN
admet-376	459	27	membrane	membrane	NOUN
admet-376	459	28	transporters	transporter	NOUN
admet-376	459	29	,	,	PUNCT
admet-376	459	30	in	in	ADP
admet-376	459	31	:	:	PUNCT
admet-376	459	32	r.r	r.r	PROPN
admet-376	459	33	.	.	PROPN
admet-376	459	34	watson	watson	PROPN
admet-376	459	35	,	,	PUNCT
admet-376	459	36	v.r	v.r	PROPN
admet-376	459	37	.	.	PROPN
admet-376	459	38	preedy	preedy	PROPN
admet-376	459	39	,	,	PUNCT
admet-376	459	40	s.	s.	PROPN
admet-376	459	41	zibadi	zibadi	PROPN
admet-376	459	42	(	(	PUNCT
admet-376	459	43	eds	ed	NOUN
admet-376	459	44	.	.	PUNCT
admet-376	459	45	)	)	PUNCT
admet-376	459	46	polyphenols	polyphenol	NOUN
admet-376	459	47	in	in	ADP
admet-376	459	48	human	human	ADJ
admet-376	459	49	health	health	NOUN
admet-376	459	50	and	and	CCONJ
admet-376	459	51	disease	disease	NOUN
admet-376	459	52	,	,	PUNCT
admet-376	459	53	elsevier	elsevier	NOUN
admet-376	459	54	,	,	PUNCT
admet-376	459	55	amsterdam	amsterdam	PROPN
admet-376	459	56	,	,	PUNCT
admet-376	459	57	2014	2014	NUM
admet-376	459	58	,	,	PUNCT
admet-376	459	59	pp	pp	ADJ
admet-376	459	60	.	.	PUNCT
admet-376	460	1	489	489	NUM
admet-376	460	2	-	-	SYM
admet-376	460	3	511	511	NUM
admet-376	460	4	.	.	PUNCT
admet-376	461	1	[	[	X
admet-376	461	2	73	73	NUM
admet-376	461	3	]	]	PUNCT
admet-376	461	4	b.	b.	PROPN
admet-376	461	5	lies	lies	PROPN
admet-376	461	6	,	,	PUNCT
admet-376	461	7	s.	s.	PROPN
admet-376	461	8	martens	martens	PROPN
admet-376	461	9	,	,	PUNCT
admet-376	461	10	s.	s.	PROPN
admet-376	461	11	schmidt	schmidt	PROPN
admet-376	461	12	,	,	PUNCT
admet-376	461	13	m.	m.	NOUN
admet-376	461	14	boll	boll	PROPN
admet-376	461	15	,	,	PUNCT
admet-376	461	16	u.	u.	PROPN
admet-376	461	17	wenzel	wenzel	PROPN
admet-376	461	18	.	.	PUNCT
admet-376	462	1	flavone	flavone	PROPN
admet-376	462	2	potently	potently	ADV
admet-376	462	3	stimulates	stimulate	VERB
admet-376	462	4	an	an	DET
admet-376	462	5	apical	apical	ADJ
admet-376	462	6	transporter	transporter	NOUN
admet-376	462	7	for	for	ADP
admet-376	462	8	flavonoids	flavonoid	NOUN
admet-376	462	9	in	in	ADP
admet-376	462	10	human	human	ADJ
admet-376	462	11	intestinal	intestinal	ADJ
admet-376	462	12	caco-2	caco-2	NUM
admet-376	462	13	cells	cell	NOUN
admet-376	462	14	,	,	PUNCT
admet-376	462	15	mol	mol	ADP
admet-376	462	16	nutr	nutr	NOUN
admet-376	462	17	food	food	NOUN
admet-376	462	18	res	re	NOUN
admet-376	462	19	56	56	NUM
admet-376	462	20	(	(	PUNCT
admet-376	462	21	2012	2012	NUM
admet-376	462	22	)	)	PUNCT
admet-376	462	23	1627	1627	NUM
admet-376	462	24	-	-	SYM
admet-376	462	25	1635	1635	NUM
admet-376	462	26	.	.	PUNCT
admet-376	463	1	[	[	X
admet-376	463	2	74	74	NUM
admet-376	463	3	]	]	PUNCT
admet-376	463	4	e.	e.	PROPN
admet-376	463	5	braidot	braidot	PROPN
admet-376	463	6	,	,	PUNCT
admet-376	463	7	e.	e.	PROPN
admet-376	463	8	petrussa	petrussa	PROPN
admet-376	463	9	,	,	PUNCT
admet-376	463	10	a.	a.	NOUN
admet-376	463	11	bertolini	bertolini	PROPN
admet-376	463	12	,	,	PUNCT
admet-376	463	13	c.	c.	PROPN
admet-376	463	14	peresson	peresson	PROPN
admet-376	463	15	,	,	PUNCT
admet-376	463	16	p.	p.	PROPN
admet-376	463	17	ermacora	ermacora	PROPN
admet-376	463	18	,	,	PUNCT
admet-376	463	19	n.	n.	PROPN
admet-376	463	20	loi	loi	PROPN
admet-376	463	21	,	,	PUNCT
admet-376	463	22	m.	m.	NOUN
admet-376	463	23	terdoslavich	terdoslavich	PROPN
admet-376	463	24	,	,	PUNCT
admet-376	463	25	s.	s.	PROPN
admet-376	463	26	passamonti	passamonti	PROPN
admet-376	463	27	,	,	PUNCT
admet-376	463	28	f.	f.	PROPN
admet-376	463	29	macri	macri	PROPN
admet-376	463	30	,	,	PUNCT
admet-376	463	31	a.	a.	NOUN
admet-376	463	32	vianello	vianello	PROPN
admet-376	463	33	.	.	PUNCT
admet-376	464	1	evidence	evidence	NOUN
admet-376	464	2	for	for	ADP
admet-376	464	3	a	a	DET
admet-376	464	4	putative	putative	ADJ
admet-376	464	5	flavonoid	flavonoid	NOUN
admet-376	464	6	translocator	translocator	NOUN
admet-376	464	7	similar	similar	ADJ
admet-376	464	8	to	to	ADP
admet-376	464	9	mammalian	mammalian	NOUN
admet-376	464	10	bilitranslocase	bilitranslocase	NOUN
admet-376	464	11	in	in	ADP
admet-376	464	12	grape	grape	NOUN
admet-376	464	13	berries	berry	NOUN
admet-376	464	14	(	(	PUNCT
admet-376	464	15	vitis	vitis	ADJ
admet-376	464	16	vinifera	vinifera	NOUN
admet-376	464	17	l.	l.	NOUN
admet-376	464	18	)	)	PUNCT
admet-376	464	19	during	during	ADP
admet-376	464	20	ripening	ripening	NOUN
admet-376	464	21	,	,	PUNCT
admet-376	464	22	planta	planta	NOUN
admet-376	464	23	228	228	NUM
admet-376	464	24	(	(	PUNCT
admet-376	464	25	2008	2008	NUM
admet-376	464	26	)	)	PUNCT
admet-376	464	27	203	203	NUM
admet-376	464	28	-	-	SYM
admet-376	464	29	213	213	NUM
admet-376	464	30	.	.	PUNCT
admet-376	465	1	[	[	X
admet-376	465	2	75	75	NUM
admet-376	465	3	]	]	PUNCT
admet-376	465	4	a.	a.	NOUN
admet-376	465	5	karawajczyk	karawajczyk	PROPN
admet-376	465	6	,	,	PUNCT
admet-376	465	7	v.	v.	ADP
admet-376	465	8	drgan	drgan	PROPN
admet-376	465	9	,	,	PUNCT
admet-376	465	10	n.	n.	NOUN
admet-376	465	11	medic	medic	NOUN
admet-376	465	12	,	,	PUNCT
admet-376	465	13	g.	g.	PROPN
admet-376	465	14	oboh	oboh	PROPN
admet-376	465	15	,	,	PUNCT
admet-376	465	16	s.	s.	PROPN
admet-376	465	17	passamonti	passamonti	PROPN
admet-376	465	18	,	,	PUNCT
admet-376	465	19	m.	m.	NOUN
admet-376	465	20	novič	novič	ADJ
admet-376	465	21	.	.	PUNCT
admet-376	466	1	properties	property	NOUN
admet-376	466	2	of	of	ADP
admet-376	466	3	flavonoids	flavonoid	NOUN
admet-376	466	4	influencing	influence	VERB
admet-376	466	5	the	the	DET
admet-376	466	6	binding	binding	NOUN
admet-376	466	7	to	to	PART
admet-376	466	8	bilitranslocase	bilitranslocase	VERB
admet-376	466	9	investigated	investigate	VERB
admet-376	466	10	by	by	ADP
admet-376	466	11	neural	neural	ADJ
admet-376	466	12	network	network	NOUN
admet-376	466	13	modelling	modelling	NOUN
admet-376	466	14	,	,	PUNCT
admet-376	466	15	biochem	biochem	PROPN
admet-376	466	16	pharmacol	pharmacol	VERB
admet-376	466	17	73	73	NUM
admet-376	466	18	(	(	PUNCT
admet-376	466	19	2007	2007	NUM
admet-376	466	20	)	)	PUNCT
admet-376	466	21	308	308	NUM
admet-376	466	22	-	-	SYM
admet-376	466	23	320	320	NUM
admet-376	466	24	.	.	PUNCT
admet-376	467	1	[	[	X
admet-376	467	2	76	76	NUM
admet-376	467	3	]	]	X
admet-376	467	4	s.	s.	PROPN
admet-376	467	5	passamonti	passamonti	PROPN
admet-376	467	6	,	,	PUNCT
admet-376	467	7	u.	u.	PROPN
admet-376	467	8	vrhovsek	vrhovsek	PROPN
admet-376	467	9	,	,	PUNCT
admet-376	467	10	f.	f.	PROPN
admet-376	467	11	mattivi	mattivi	PROPN
admet-376	467	12	.	.	PUNCT
admet-376	468	1	the	the	DET
admet-376	468	2	interaction	interaction	NOUN
admet-376	468	3	of	of	ADP
admet-376	468	4	anthocyanins	anthocyanin	NOUN
admet-376	468	5	with	with	ADP
admet-376	468	6	bilitranslocase	bilitranslocase	NOUN
admet-376	468	7	,	,	PUNCT
admet-376	468	8	biochem	biochem	PROPN
admet-376	468	9	biophys	biophy	NOUN
admet-376	468	10	res	re	NOUN
admet-376	468	11	commun	commun	PROPN
admet-376	468	12	296	296	NUM
admet-376	468	13	(	(	PUNCT
admet-376	468	14	2002	2002	NUM
admet-376	468	15	)	)	PUNCT
admet-376	468	16	631	631	NUM
admet-376	468	17	-	-	SYM
admet-376	468	18	636	636	NUM
admet-376	468	19	.	.	PUNCT
admet-376	469	1	[	[	X
admet-376	469	2	77	77	NUM
admet-376	469	3	]	]	X
admet-376	469	4	s.	s.	PROPN
admet-376	469	5	passamonti	passamonti	PROPN
admet-376	469	6	,	,	PUNCT
admet-376	469	7	a.	a.	NOUN
admet-376	469	8	vanzo	vanzo	PROPN
admet-376	469	9	,	,	PUNCT
admet-376	469	10	u.	u.	NOUN
admet-376	469	11	vrhovsek	vrhovsek	PROPN
admet-376	469	12	,	,	PUNCT
admet-376	469	13	m.	m.	NOUN
admet-376	469	14	terdoslavich	terdoslavich	PROPN
admet-376	469	15	,	,	PUNCT
admet-376	469	16	a.	a.	PROPN
admet-376	469	17	cocolo	cocolo	PROPN
admet-376	469	18	,	,	PUNCT
admet-376	469	19	g.	g.	PROPN
admet-376	469	20	decorti	decorti	PROPN
admet-376	469	21	,	,	PUNCT
admet-376	469	22	f.	f.	PROPN
admet-376	469	23	mattivi	mattivi	PROPN
admet-376	469	24	.	.	PUNCT
admet-376	470	1	hepatic	hepatic	ADJ
admet-376	470	2	uptake	uptake	NOUN
admet-376	470	3	of	of	ADP
admet-376	470	4	grape	grape	NOUN
admet-376	470	5	anthocyanins	anthocyanin	NOUN
admet-376	470	6	and	and	CCONJ
admet-376	470	7	the	the	DET
admet-376	470	8	role	role	NOUN
admet-376	470	9	of	of	ADP
admet-376	470	10	bilitranslocase	bilitranslocase	NOUN
admet-376	470	11	,	,	PUNCT
admet-376	470	12	food	food	NOUN
admet-376	470	13	res	re	NOUN
admet-376	470	14	internat	internat	NOUN
admet-376	470	15	38	38	NUM
admet-376	470	16	(	(	PUNCT
admet-376	470	17	2005	2005	NUM
admet-376	470	18	)	)	PUNCT
admet-376	470	19	953	953	NUM
admet-376	470	20	-	-	SYM
admet-376	470	21	960	960	NUM
admet-376	470	22	.	.	PUNCT
admet-376	471	1	[	[	X
admet-376	471	2	78	78	NUM
admet-376	471	3	]	]	PUNCT
admet-376	471	4	a.	a.	NOUN
admet-376	471	5	vanzo	vanzo	PROPN
admet-376	471	6	,	,	PUNCT
admet-376	471	7	m.	m.	NOUN
admet-376	471	8	terdoslavich	terdoslavich	PROPN
admet-376	471	9	,	,	PUNCT
admet-376	471	10	a.	a.	NOUN
admet-376	471	11	brandoni	brandoni	PROPN
admet-376	471	12	,	,	PUNCT
admet-376	471	13	a.m.	a.m.	PROPN
admet-376	471	14	torres	torre	VERB
admet-376	471	15	,	,	PUNCT
admet-376	471	16	u.	u.	PROPN
admet-376	471	17	vrhovsek	vrhovsek	PROPN
admet-376	471	18	,	,	PUNCT
admet-376	471	19	s.	s.	PROPN
admet-376	471	20	passamonti	passamonti	PROPN
admet-376	471	21	.	.	PUNCT
admet-376	472	1	uptake	uptake	ADJ
admet-376	472	2	of	of	ADP
admet-376	472	3	grape	grape	NOUN
admet-376	472	4	anthocyanins	anthocyanin	NOUN
admet-376	472	5	into	into	ADP
admet-376	472	6	the	the	DET
admet-376	472	7	rat	rat	NOUN
admet-376	472	8	kidney	kidney	NOUN
admet-376	472	9	and	and	CCONJ
admet-376	472	10	the	the	DET
admet-376	472	11	involvement	involvement	NOUN
admet-376	472	12	of	of	ADP
admet-376	472	13	bilitranslocase	bilitranslocase	NOUN
admet-376	472	14	,	,	PUNCT
admet-376	472	15	mol	mol	ADP
admet-376	472	16	nutr	nutr	NOUN
admet-376	472	17	food	food	NOUN
admet-376	472	18	res	re	NOUN
admet-376	472	19	52	52	NUM
admet-376	472	20	(	(	PUNCT
admet-376	472	21	2008	2008	NUM
admet-376	472	22	)	)	PUNCT
admet-376	472	23	1106	1106	NUM
admet-376	472	24	-	-	SYM
admet-376	472	25	1116	1116	NUM
admet-376	472	26	.	.	PUNCT
admet-376	473	1	[	[	X
admet-376	473	2	79	79	NUM
admet-376	473	3	]	]	PUNCT
admet-376	473	4	s.	s.	PROPN
admet-376	473	5	passamonti	passamonti	PROPN
admet-376	473	6	,	,	PUNCT
admet-376	473	7	m.	m.	NOUN
admet-376	473	8	terdoslavich	terdoslavich	PROPN
admet-376	473	9	,	,	PUNCT
admet-376	473	10	r.	r.	PROPN
admet-376	473	11	franca	franca	PROPN
admet-376	473	12	,	,	PUNCT
admet-376	473	13	a.	a.	NOUN
admet-376	473	14	vanzo	vanzo	PROPN
admet-376	473	15	,	,	PUNCT
admet-376	473	16	f.	f.	PROPN
admet-376	473	17	tramer	tramer	PROPN
admet-376	473	18	,	,	PUNCT
admet-376	473	19	e.	e.	PROPN
admet-376	473	20	braidot	braidot	PROPN
admet-376	473	21	,	,	PUNCT
admet-376	473	22	e.	e.	PROPN
admet-376	473	23	petrussa	petrussa	PROPN
admet-376	473	24	,	,	PUNCT
admet-376	473	25	a.	a.	NOUN
admet-376	473	26	vianello	vianello	PROPN
admet-376	473	27	.	.	PUNCT
admet-376	474	1	bioavailability	bioavailability	NOUN
admet-376	474	2	of	of	ADP
admet-376	474	3	flavonoids	flavonoid	NOUN
admet-376	474	4	:	:	PUNCT
admet-376	474	5	a	a	DET
admet-376	474	6	review	review	NOUN
admet-376	474	7	of	of	ADP
admet-376	474	8	their	their	PRON
admet-376	474	9	membrane	membrane	NOUN
admet-376	474	10	transport	transport	NOUN
admet-376	474	11	and	and	CCONJ
admet-376	474	12	the	the	DET
admet-376	474	13	function	function	NOUN
admet-376	474	14	of	of	ADP
admet-376	474	15	bilitranslocase	bilitranslocase	NOUN
admet-376	474	16	in	in	ADP
admet-376	474	17	animal	animal	NOUN
admet-376	474	18	and	and	CCONJ
admet-376	474	19	plant	plant	NOUN
admet-376	474	20	organisms	organism	NOUN
admet-376	474	21	,	,	PUNCT
admet-376	474	22	curr	curr	PROPN
admet-376	474	23	drug	drug	NOUN
admet-376	474	24	metab	metab	PROPN
admet-376	474	25	10	10	NUM
admet-376	474	26	(	(	PUNCT
admet-376	474	27	2009	2009	NUM
admet-376	474	28	)	)	PUNCT
admet-376	474	29	369	369	NUM
admet-376	474	30	-	-	SYM
admet-376	474	31	394	394	NUM
admet-376	474	32	.	.	PUNCT
admet-376	475	1	[	[	X
admet-376	475	2	80	80	NUM
admet-376	475	3	]	]	X
admet-376	475	4	f.	f.	PROPN
admet-376	475	5	jackson	jackson	PROPN
admet-376	475	6	.	.	PUNCT
admet-376	476	1	the	the	DET
admet-376	476	2	coevolutionary	coevolutionary	PROPN
admet-376	476	3	relationship	relationship	NOUN
admet-376	476	4	of	of	ADP
admet-376	476	5	humans	human	NOUN
admet-376	476	6	and	and	CCONJ
admet-376	476	7	domesticated	domesticate	VERB
admet-376	476	8	plants	plant	NOUN
admet-376	476	9	,	,	PUNCT
admet-376	476	10	yearbook	yearbook	NOUN
admet-376	476	11	of	of	ADP
admet-376	476	12	physical	physical	ADJ
admet-376	476	13	anthropology	anthropology	NOUN
admet-376	476	14	39	39	NUM
admet-376	476	15	(	(	PUNCT
admet-376	476	16	1996	1996	NUM
admet-376	476	17	)	)	PUNCT
admet-376	476	18	161	161	NUM
admet-376	476	19	-	-	SYM
admet-376	476	20	176	176	NUM
admet-376	476	21	.	.	PUNCT
admet-376	477	1	[	[	X
admet-376	477	2	81	81	NUM
admet-376	477	3	]	]	PUNCT
admet-376	477	4	t.	t.	PROPN
admet-376	477	5	johns	johns	PROPN
admet-376	477	6	.	.	PUNCT
admet-376	478	1	the	the	DET
admet-376	478	2	chemical	chemical	ADJ
admet-376	478	3	ecology	ecology	NOUN
admet-376	478	4	of	of	ADP
admet-376	478	5	human	human	ADJ
admet-376	478	6	ingestive	ingestive	ADJ
admet-376	478	7	behaviors	behavior	NOUN
admet-376	478	8	,	,	PUNCT
admet-376	478	9	ann	ann	PROPN
admet-376	478	10	rev	rev	PROPN
admet-376	478	11	anthropol	anthropol	PROPN
admet-376	478	12	28	28	NUM
admet-376	478	13	(	(	PUNCT
admet-376	478	14	1999	1999	NUM
admet-376	478	15	)	)	PUNCT
admet-376	478	16	27	27	NUM
admet-376	478	17	-	-	SYM
admet-376	478	18	50	50	NUM
admet-376	478	19	.	.	PUNCT
admet-376	478	20	o'hagan	o'hagan	PROPN
admet-376	478	21	&	&	CCONJ
admet-376	478	22	kell	kell	PROPN
admet-376	478	23	admet	admet	PROPN
admet-376	478	24	&	&	CCONJ
admet-376	478	25	dmpk	dmpk	PROPN
admet-376	478	26	5(2	5(2	NUM
admet-376	478	27	)	)	PUNCT
admet-376	478	28	(	(	PUNCT
admet-376	478	29	2017	2017	NUM
admet-376	478	30	)	)	PUNCT
admet-376	478	31	85	85	NUM
admet-376	478	32	-	-	SYM
admet-376	478	33	125	125	NUM
admet-376	478	34	118	118	NUM
admet-376	478	35	[	[	X
admet-376	478	36	82	82	NUM
admet-376	478	37	]	]	X
admet-376	478	38	r.j	r.j	PROPN
admet-376	478	39	.	.	PROPN
admet-376	478	40	sullivan	sullivan	PROPN
admet-376	478	41	,	,	PUNCT
admet-376	478	42	e.h	e.h	PROPN
admet-376	478	43	.	.	PROPN
admet-376	478	44	hagen	hagen	PROPN
admet-376	478	45	,	,	PUNCT
admet-376	478	46	p.	p.	PROPN
admet-376	478	47	hammerstein	hammerstein	PROPN
admet-376	478	48	.	.	PUNCT
admet-376	479	1	revealing	reveal	VERB
admet-376	479	2	the	the	DET
admet-376	479	3	paradox	paradox	NOUN
admet-376	479	4	of	of	ADP
admet-376	479	5	drug	drug	NOUN
admet-376	479	6	reward	reward	NOUN
admet-376	479	7	in	in	ADP
admet-376	479	8	human	human	ADJ
admet-376	479	9	evolution	evolution	NOUN
admet-376	479	10	,	,	PUNCT
admet-376	479	11	p	p	PROPN
admet-376	479	12	roy	roy	PROPN
admet-376	479	13	soc	soc	PROPN
admet-376	479	14	b	b	PROPN
admet-376	479	15	-	-	PUNCT
admet-376	479	16	biol	biol	ADJ
admet-376	479	17	sci	sci	PROPN
admet-376	479	18	275	275	NUM
admet-376	479	19	(	(	PUNCT
admet-376	479	20	2008	2008	NUM
admet-376	479	21	)	)	PUNCT
admet-376	479	22	1231	1231	NUM
admet-376	479	23	-	-	SYM
admet-376	479	24	1241	1241	NUM
admet-376	479	25	.	.	PUNCT
admet-376	480	1	[	[	X
admet-376	480	2	83	83	NUM
admet-376	480	3	]	]	X
admet-376	480	4	o.	o.	NOUN
admet-376	480	5	arjamaa	arjamaa	PROPN
admet-376	480	6	,	,	PUNCT
admet-376	480	7	t.	t.	NOUN
admet-376	480	8	vuorisalo	vuorisalo	NOUN
admet-376	480	9	.	.	PUNCT
admet-376	481	1	gene	gene	NOUN
admet-376	481	2	-	-	PUNCT
admet-376	481	3	culture	culture	NOUN
admet-376	481	4	coevolution	coevolution	NOUN
admet-376	481	5	and	and	CCONJ
admet-376	481	6	human	human	ADJ
admet-376	481	7	diet	diet	NOUN
admet-376	481	8	,	,	PUNCT
admet-376	481	9	am	be	AUX
admet-376	481	10	sci	sci	PROPN
admet-376	481	11	98	98	NUM
admet-376	481	12	(	(	PUNCT
admet-376	481	13	2010	2010	NUM
admet-376	481	14	)	)	PUNCT
admet-376	481	15	140	140	NUM
admet-376	481	16	-	-	SYM
admet-376	481	17	147	147	NUM
admet-376	481	18	.	.	PUNCT
admet-376	482	1	[	[	X
admet-376	482	2	84	84	NUM
admet-376	482	3	]	]	X
admet-376	482	4	r.e	r.e	PROPN
admet-376	482	5	.	.	PROPN
admet-376	482	6	ley	ley	PROPN
admet-376	482	7	,	,	PUNCT
admet-376	482	8	m.	m.	NOUN
admet-376	482	9	hamady	hamady	PROPN
admet-376	482	10	,	,	PUNCT
admet-376	482	11	c.	c.	PROPN
admet-376	482	12	lozupone	lozupone	PROPN
admet-376	482	13	,	,	PUNCT
admet-376	482	14	p.j	p.j	PROPN
admet-376	482	15	.	.	PROPN
admet-376	482	16	turnbaugh	turnbaugh	PROPN
admet-376	482	17	,	,	PUNCT
admet-376	482	18	r.r	r.r	PROPN
admet-376	482	19	.	.	PROPN
admet-376	482	20	ramey	ramey	PROPN
admet-376	482	21	,	,	PUNCT
admet-376	482	22	j.s	j.s	PROPN
admet-376	482	23	.	.	PROPN
admet-376	482	24	bircher	bircher	PROPN
admet-376	482	25	,	,	PUNCT
admet-376	482	26	m.l	m.l	PROPN
admet-376	482	27	.	.	PROPN
admet-376	482	28	schlegel	schlegel	PROPN
admet-376	482	29	,	,	PUNCT
admet-376	482	30	t.a	t.a	PROPN
admet-376	482	31	.	.	PROPN
admet-376	482	32	tucker	tucker	PROPN
admet-376	482	33	,	,	PUNCT
admet-376	482	34	m.d	m.d	PROPN
admet-376	482	35	.	.	PROPN
admet-376	482	36	schrenzel	schrenzel	PROPN
admet-376	482	37	,	,	PUNCT
admet-376	482	38	r.	r.	PROPN
admet-376	482	39	knight	knight	PROPN
admet-376	482	40	,	,	PUNCT
admet-376	482	41	j.i	j.i	PROPN
admet-376	482	42	.	.	PROPN
admet-376	482	43	gordon	gordon	PROPN
admet-376	482	44	.	.	PUNCT
admet-376	483	1	evolution	evolution	NOUN
admet-376	483	2	of	of	ADP
admet-376	483	3	mammals	mammal	NOUN
admet-376	483	4	and	and	CCONJ
admet-376	483	5	their	their	PRON
admet-376	483	6	gut	gut	NOUN
admet-376	483	7	microbes	microbe	NOUN
admet-376	483	8	,	,	PUNCT
admet-376	483	9	science	science	NOUN
admet-376	483	10	320	320	NUM
admet-376	483	11	(	(	PUNCT
admet-376	483	12	2008	2008	NUM
admet-376	483	13	)	)	PUNCT
admet-376	483	14	1647	1647	NUM
admet-376	483	15	-	-	SYM
admet-376	483	16	1651	1651	NUM
admet-376	483	17	.	.	PUNCT
admet-376	484	1	[	[	X
admet-376	484	2	85	85	NUM
admet-376	484	3	]	]	X
admet-376	484	4	b.d	b.d	PROPN
admet-376	484	5	.	.	PROPN
admet-376	484	6	muegge	muegge	PROPN
admet-376	484	7	,	,	PUNCT
admet-376	484	8	j.	j.	PROPN
admet-376	484	9	kuczynski	kuczynski	PROPN
admet-376	484	10	,	,	PUNCT
admet-376	484	11	d.	d.	PROPN
admet-376	484	12	knights	knights	PROPN
admet-376	484	13	,	,	PUNCT
admet-376	484	14	j.c	j.c	PROPN
admet-376	484	15	.	.	PROPN
admet-376	484	16	clemente	clemente	PROPN
admet-376	484	17	,	,	PUNCT
admet-376	484	18	a.	a.	PROPN
admet-376	484	19	gonzález	gonzález	PROPN
admet-376	484	20	,	,	PUNCT
admet-376	484	21	l.	l.	PROPN
admet-376	484	22	fontana	fontana	PROPN
admet-376	484	23	,	,	PUNCT
admet-376	484	24	b.	b.	PROPN
admet-376	484	25	henrissat	henrissat	PROPN
admet-376	484	26	,	,	PUNCT
admet-376	484	27	r.	r.	PROPN
admet-376	484	28	knight	knight	PROPN
admet-376	484	29	,	,	PUNCT
admet-376	484	30	j.i	j.i	PROPN
admet-376	484	31	.	.	PROPN
admet-376	484	32	gordon	gordon	PROPN
admet-376	484	33	.	.	PUNCT
admet-376	485	1	diet	diet	PROPN
admet-376	485	2	drives	drive	VERB
admet-376	485	3	convergence	convergence	NOUN
admet-376	485	4	in	in	ADP
admet-376	485	5	gut	gut	NOUN
admet-376	485	6	microbiome	microbiome	NOUN
admet-376	485	7	functions	function	NOUN
admet-376	485	8	across	across	ADP
admet-376	485	9	mammalian	mammalian	ADJ
admet-376	485	10	phylogeny	phylogeny	NOUN
admet-376	485	11	and	and	CCONJ
admet-376	485	12	within	within	ADP
admet-376	485	13	humans	human	NOUN
admet-376	485	14	,	,	PUNCT
admet-376	485	15	science	science	NOUN
admet-376	485	16	332	332	NUM
admet-376	485	17	(	(	PUNCT
admet-376	485	18	2011	2011	NUM
admet-376	485	19	)	)	PUNCT
admet-376	485	20	970	970	NUM
admet-376	485	21	-	-	SYM
admet-376	485	22	974	974	NUM
admet-376	485	23	.	.	PUNCT
admet-376	486	1	[	[	X
admet-376	486	2	86	86	NUM
admet-376	486	3	]	]	X
admet-376	486	4	p.j	p.j	PROPN
admet-376	486	5	.	.	PROPN
admet-376	486	6	richerson	richerson	PROPN
admet-376	486	7	,	,	PUNCT
admet-376	486	8	r.	r.	PROPN
admet-376	486	9	boyd	boyd	PROPN
admet-376	486	10	,	,	PUNCT
admet-376	486	11	j.	j.	PROPN
admet-376	486	12	henrich	henrich	PROPN
admet-376	486	13	.	.	PUNCT
admet-376	487	1	gene	gene	NOUN
admet-376	487	2	-	-	PUNCT
admet-376	487	3	culture	culture	NOUN
admet-376	487	4	coevolution	coevolution	NOUN
admet-376	487	5	in	in	ADP
admet-376	487	6	the	the	DET
admet-376	487	7	age	age	NOUN
admet-376	487	8	of	of	ADP
admet-376	487	9	genomics	genomic	NOUN
admet-376	487	10	,	,	PUNCT
admet-376	487	11	proc	proc	PROPN
admet-376	487	12	natl	natl	PROPN
admet-376	487	13	acad	acad	PROPN
admet-376	487	14	sci	sci	PROPN
admet-376	487	15	u	u	PROPN
admet-376	487	16	s	s	PROPN
admet-376	487	17	a	a	DET
admet-376	487	18	107	107	NUM
admet-376	487	19	suppl	suppl	ADJ
admet-376	487	20	2	2	NUM
admet-376	487	21	(	(	PUNCT
admet-376	487	22	2010	2010	NUM
admet-376	487	23	)	)	PUNCT
admet-376	487	24	8985	8985	NUM
admet-376	487	25	-	-	SYM
admet-376	487	26	8992	8992	NUM
admet-376	487	27	.	.	PUNCT
admet-376	488	1	[	[	X
admet-376	488	2	87	87	NUM
admet-376	488	3	]	]	PUNCT
admet-376	488	4	a.	a.	NOUN
admet-376	488	5	de	de	X
admet-376	488	6	pasquale	pasquale	PROPN
admet-376	488	7	.	.	PUNCT
admet-376	489	1	pharmacognosy	pharmacognosy	NOUN
admet-376	489	2	:	:	PUNCT
admet-376	489	3	the	the	DET
admet-376	489	4	oldest	old	ADJ
admet-376	489	5	modern	modern	ADJ
admet-376	489	6	science	science	NOUN
admet-376	489	7	,	,	PUNCT
admet-376	489	8	j	j	PROPN
admet-376	489	9	ethnopharmacol	ethnopharmacol	PROPN
admet-376	489	10	11	11	NUM
admet-376	489	11	(	(	PUNCT
admet-376	489	12	1984	1984	NUM
admet-376	489	13	)	)	PUNCT
admet-376	489	14	1	1	NUM
admet-376	489	15	-	-	SYM
admet-376	489	16	16	16	NUM
admet-376	489	17	.	.	PUNCT
admet-376	490	1	[	[	X
admet-376	490	2	88	88	NUM
admet-376	490	3	]	]	PUNCT
admet-376	490	4	a.	a.	NOUN
admet-376	490	5	gurib	gurib	PROPN
admet-376	490	6	-	-	PUNCT
admet-376	490	7	fakim	fakim	NOUN
admet-376	490	8	.	.	PUNCT
admet-376	491	1	medicinal	medicinal	ADJ
admet-376	491	2	plants	plant	NOUN
admet-376	491	3	:	:	PUNCT
admet-376	491	4	traditions	tradition	NOUN
admet-376	491	5	of	of	ADP
admet-376	491	6	yesterday	yesterday	NOUN
admet-376	491	7	and	and	CCONJ
admet-376	491	8	drugs	drug	NOUN
admet-376	491	9	of	of	ADP
admet-376	491	10	tomorrow	tomorrow	NOUN
admet-376	491	11	,	,	PUNCT
admet-376	491	12	mol	mol	ADP
admet-376	491	13	aspects	aspect	NOUN
admet-376	491	14	med	me	VERB
admet-376	491	15	27	27	NUM
admet-376	491	16	(	(	PUNCT
admet-376	491	17	2006	2006	NUM
admet-376	491	18	)	)	PUNCT
admet-376	491	19	1	1	NUM
admet-376	491	20	-	-	SYM
admet-376	491	21	93	93	NUM
admet-376	491	22	.	.	PUNCT
admet-376	492	1	[	[	X
admet-376	492	2	89	89	NUM
admet-376	492	3	]	]	X
admet-376	492	4	v.	v.	CCONJ
admet-376	492	5	narayanaswamy	narayanaswamy	PROPN
admet-376	492	6	.	.	PUNCT
admet-376	492	7	origin	origin	NOUN
admet-376	492	8	and	and	CCONJ
admet-376	492	9	development	development	NOUN
admet-376	492	10	of	of	ADP
admet-376	492	11	ayurveda	ayurveda	NOUN
admet-376	492	12	:	:	PUNCT
admet-376	492	13	(	(	PUNCT
admet-376	492	14	a	a	DET
admet-376	492	15	brief	brief	ADJ
admet-376	492	16	history	history	NOUN
admet-376	492	17	)	)	PUNCT
admet-376	492	18	,	,	PUNCT
admet-376	492	19	anc	anc	PROPN
admet-376	492	20	sci	sci	PROPN
admet-376	492	21	life	life	NOUN
admet-376	492	22	1	1	NUM
admet-376	492	23	(	(	PUNCT
admet-376	492	24	1981	1981	NUM
admet-376	492	25	)	)	PUNCT
admet-376	492	26	1	1	NUM
admet-376	492	27	-	-	SYM
admet-376	492	28	7	7	NUM
admet-376	492	29	.	.	PUNCT
admet-376	493	1	[	[	X
admet-376	493	2	90	90	NUM
admet-376	493	3	]	]	PUNCT
admet-376	493	4	f.	f.	PROPN
admet-376	493	5	mohd	mohd	PROPN
admet-376	493	6	fauzi	fauzi	PROPN
admet-376	493	7	,	,	PUNCT
admet-376	493	8	a.	a.	PROPN
admet-376	493	9	koutsoukas	koutsoukas	PROPN
admet-376	493	10	,	,	PUNCT
admet-376	493	11	r.	r.	PROPN
admet-376	493	12	lowe	lowe	PROPN
admet-376	493	13	,	,	PUNCT
admet-376	493	14	k.	k.	PROPN
admet-376	493	15	joshi	joshi	PROPN
admet-376	493	16	,	,	PUNCT
admet-376	493	17	t.p	t.p	PROPN
admet-376	493	18	.	.	PROPN
admet-376	493	19	fan	fan	PROPN
admet-376	493	20	,	,	PUNCT
admet-376	493	21	r.c	r.c	PROPN
admet-376	493	22	.	.	PROPN
admet-376	493	23	glen	glen	PROPN
admet-376	493	24	,	,	PUNCT
admet-376	493	25	a.	a.	NOUN
admet-376	493	26	bender	bender	PROPN
admet-376	493	27	.	.	PUNCT
admet-376	494	1	chemogenomics	chemogenomic	NOUN
admet-376	494	2	approaches	approach	NOUN
admet-376	494	3	to	to	ADP
admet-376	494	4	rationalizing	rationalize	VERB
admet-376	494	5	the	the	DET
admet-376	494	6	mode	mode	NOUN
admet-376	494	7	-	-	PUNCT
admet-376	494	8	of	of	ADP
admet-376	494	9	-	-	PUNCT
admet-376	494	10	action	action	NOUN
admet-376	494	11	of	of	ADP
admet-376	494	12	traditional	traditional	ADJ
admet-376	494	13	chinese	chinese	PROPN
admet-376	494	14	and	and	CCONJ
admet-376	494	15	ayurvedic	ayurvedic	ADJ
admet-376	494	16	medicines	medicine	NOUN
admet-376	494	17	,	,	PUNCT
admet-376	494	18	j	j	PROPN
admet-376	494	19	chem	chem	PROPN
admet-376	494	20	inf	inf	PROPN
admet-376	494	21	model	model	NOUN
admet-376	494	22	53	53	NUM
admet-376	494	23	(	(	PUNCT
admet-376	494	24	2013	2013	NUM
admet-376	494	25	)	)	PUNCT
admet-376	494	26	661	661	NUM
admet-376	494	27	-	-	SYM
admet-376	494	28	673	673	NUM
admet-376	494	29	.	.	PUNCT
admet-376	495	1	[	[	X
admet-376	495	2	91	91	NUM
admet-376	495	3	]	]	X
admet-376	495	4	v.k	v.k	PROPN
admet-376	495	5	.	.	PROPN
admet-376	495	6	joshi	joshi	PROPN
admet-376	495	7	,	,	PUNCT
admet-376	495	8	a.	a.	PROPN
admet-376	495	9	joshi	joshi	PROPN
admet-376	495	10	,	,	PUNCT
admet-376	495	11	k.s	k.s	PROPN
admet-376	495	12	.	.	PROPN
admet-376	495	13	dhiman	dhiman	NOUN
admet-376	495	14	.	.	PUNCT
admet-376	496	1	the	the	DET
admet-376	496	2	ayurvedic	ayurvedic	ADJ
admet-376	496	3	pharmacopoeia	pharmacopoeia	NOUN
admet-376	496	4	of	of	ADP
admet-376	496	5	india	india	PROPN
admet-376	496	6	,	,	PUNCT
admet-376	496	7	development	development	NOUN
admet-376	496	8	and	and	CCONJ
admet-376	496	9	perspectives	perspective	NOUN
admet-376	496	10	,	,	PUNCT
admet-376	496	11	j	j	PROPN
admet-376	496	12	ethnopharmacol	ethnopharmacol	PROPN
admet-376	496	13	(	(	PUNCT
admet-376	496	14	2016	2016	NUM
admet-376	496	15	)	)	PUNCT
admet-376	496	16	.	.	PUNCT
admet-376	497	1	[	[	X
admet-376	497	2	92	92	NUM
admet-376	497	3	]	]	X
admet-376	497	4	y.	y.	PROPN
admet-376	497	5	jaiswal	jaiswal	PROPN
admet-376	497	6	,	,	PUNCT
admet-376	497	7	z.	z.	PROPN
admet-376	497	8	liang	liang	PROPN
admet-376	497	9	,	,	PUNCT
admet-376	497	10	z.	z.	PROPN
admet-376	497	11	zhao	zhao	PROPN
admet-376	497	12	.	.	PUNCT
admet-376	498	1	botanical	botanical	ADJ
admet-376	498	2	drugs	drug	NOUN
admet-376	498	3	in	in	ADP
admet-376	498	4	ayurveda	ayurveda	NOUN
admet-376	498	5	and	and	CCONJ
admet-376	498	6	traditional	traditional	ADJ
admet-376	498	7	chinese	chinese	ADJ
admet-376	498	8	medicine	medicine	NOUN
admet-376	498	9	,	,	PUNCT
admet-376	498	10	j	j	PROPN
admet-376	498	11	ethnopharmacol	ethnopharmacol	PROPN
admet-376	498	12	(	(	PUNCT
admet-376	498	13	2016	2016	NUM
admet-376	498	14	)	)	PUNCT
admet-376	498	15	.	.	PUNCT
admet-376	499	1	[	[	X
admet-376	499	2	93	93	NUM
admet-376	499	3	]	]	X
admet-376	499	4	g.l	g.l	PROPN
admet-376	499	5	.	.	PROPN
admet-376	499	6	yang	yang	PROPN
admet-376	499	7	,	,	PUNCT
admet-376	499	8	w.	w.	PROPN
admet-376	499	9	gu	gu	PROPN
admet-376	499	10	,	,	PUNCT
admet-376	499	11	h.q	h.q	PROPN
admet-376	499	12	.	.	PROPN
admet-376	499	13	zhang	zhang	PROPN
admet-376	499	14	,	,	PUNCT
admet-376	499	15	x.f	x.f	PROPN
admet-376	500	1	.	.	PROPN
admet-376	500	2	zhai	zhai	PROPN
admet-376	500	3	,	,	PUNCT
admet-376	500	4	x.q	x.q	PROPN
admet-376	500	5	.	.	PROPN
admet-376	500	6	li	li	PROPN
admet-376	500	7	,	,	PUNCT
admet-376	500	8	c.q	c.q	PROPN
admet-376	500	9	.	.	PROPN
admet-376	500	10	ling	ling	PROPN
admet-376	500	11	.	.	PUNCT
admet-376	501	1	the	the	DET
admet-376	501	2	application	application	NOUN
admet-376	501	3	status	status	NOUN
admet-376	501	4	of	of	ADP
admet-376	501	5	chinese	chinese	ADJ
admet-376	501	6	herbal	herbal	ADJ
admet-376	501	7	medicine	medicine	NOUN
admet-376	501	8	in	in	ADP
admet-376	501	9	military	military	ADJ
admet-376	501	10	health	health	NOUN
admet-376	501	11	service	service	NOUN
admet-376	501	12	in	in	ADP
admet-376	501	13	china	china	PROPN
admet-376	501	14	,	,	PUNCT
admet-376	501	15	chinese	chinese	ADJ
admet-376	501	16	journal	journal	NOUN
admet-376	501	17	of	of	ADP
admet-376	501	18	integrative	integrative	ADJ
admet-376	501	19	medicine	medicine	NOUN
admet-376	501	20	22	22	NUM
admet-376	501	21	(	(	PUNCT
admet-376	501	22	2016	2016	NUM
admet-376	501	23	)	)	PUNCT
admet-376	501	24	555560	555560	NUM
admet-376	501	25	.	.	PUNCT
admet-376	502	1	[	[	X
admet-376	502	2	94	94	X
admet-376	502	3	]	]	X
admet-376	502	4	j.	j.	PROPN
admet-376	502	5	killgore	killgore	PROPN
admet-376	502	6	,	,	PUNCT
admet-376	502	7	c.	c.	PROPN
admet-376	502	8	smidt	smidt	PROPN
admet-376	502	9	,	,	PUNCT
admet-376	502	10	l.	l.	PROPN
admet-376	502	11	duich	duich	PROPN
admet-376	502	12	,	,	PUNCT
admet-376	502	13	n.	n.	PROPN
admet-376	502	14	romero	romero	PROPN
admet-376	502	15	-	-	PUNCT
admet-376	502	16	chapman	chapman	PROPN
admet-376	502	17	,	,	PUNCT
admet-376	502	18	d.	d.	PROPN
admet-376	502	19	tinker	tinker	PROPN
admet-376	502	20	,	,	PUNCT
admet-376	502	21	k.	k.	PROPN
admet-376	502	22	reiser	reiser	PROPN
admet-376	502	23	,	,	PUNCT
admet-376	502	24	m.	m.	PROPN
admet-376	502	25	melko	melko	PROPN
admet-376	502	26	,	,	PUNCT
admet-376	502	27	d.	d.	PROPN
admet-376	502	28	hyde	hyde	PROPN
admet-376	502	29	,	,	PUNCT
admet-376	502	30	r.b	r.b	PROPN
admet-376	502	31	.	.	PROPN
admet-376	502	32	rucker	rucker	PROPN
admet-376	502	33	.	.	PUNCT
admet-376	503	1	nutritional	nutritional	ADJ
admet-376	503	2	importance	importance	NOUN
admet-376	503	3	of	of	ADP
admet-376	503	4	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	503	5	quinone	quinone	NOUN
admet-376	503	6	,	,	PUNCT
admet-376	503	7	science	science	NOUN
admet-376	503	8	245	245	NUM
admet-376	503	9	(	(	PUNCT
admet-376	503	10	1989	1989	NUM
admet-376	503	11	)	)	PUNCT
admet-376	503	12	850	850	NUM
admet-376	503	13	-	-	SYM
admet-376	503	14	852	852	NUM
admet-376	503	15	.	.	PUNCT
admet-376	504	1	[	[	X
admet-376	504	2	95	95	NUM
admet-376	504	3	]	]	X
admet-376	504	4	t.e	t.e	PROPN
admet-376	504	5	.	.	PROPN
admet-376	504	6	stites	stites	PROPN
admet-376	504	7	,	,	PUNCT
admet-376	504	8	a.e	a.e	PROPN
admet-376	504	9	.	.	PROPN
admet-376	504	10	mitchell	mitchell	PROPN
admet-376	504	11	,	,	PUNCT
admet-376	504	12	r.b	r.b	PROPN
admet-376	504	13	.	.	PROPN
admet-376	504	14	rucker	rucker	PROPN
admet-376	504	15	.	.	PUNCT
admet-376	505	1	physiological	physiological	ADJ
admet-376	505	2	importance	importance	NOUN
admet-376	505	3	of	of	ADP
admet-376	505	4	quinoenzymes	quinoenzyme	NOUN
admet-376	505	5	and	and	CCONJ
admet-376	505	6	the	the	DET
admet-376	505	7	o	o	NOUN
admet-376	505	8	-	-	ADJ
admet-376	505	9	quinone	quinone	ADJ
admet-376	505	10	family	family	NOUN
admet-376	505	11	of	of	ADP
admet-376	505	12	cofactors	cofactor	NOUN
admet-376	505	13	,	,	PUNCT
admet-376	505	14	j	j	PROPN
admet-376	505	15	nutr	nutr	PROPN
admet-376	505	16	130	130	NUM
admet-376	505	17	(	(	PUNCT
admet-376	505	18	2000	2000	NUM
admet-376	505	19	)	)	PUNCT
admet-376	505	20	719	719	NUM
admet-376	505	21	-	-	SYM
admet-376	505	22	727	727	NUM
admet-376	505	23	.	.	PUNCT
admet-376	506	1	[	[	X
admet-376	506	2	96	96	NUM
admet-376	506	3	]	]	X
admet-376	506	4	f.	f.	PROPN
admet-376	506	5	steinberg	steinberg	PROPN
admet-376	506	6	,	,	PUNCT
admet-376	506	7	t.e	t.e	PROPN
admet-376	506	8	.	.	PROPN
admet-376	506	9	stites	stite	NOUN
admet-376	506	10	,	,	PUNCT
admet-376	506	11	p.	p.	PROPN
admet-376	506	12	anderson	anderson	PROPN
admet-376	506	13	,	,	PUNCT
admet-376	506	14	d.	d.	PROPN
admet-376	506	15	storms	storms	PROPN
admet-376	506	16	,	,	PUNCT
admet-376	506	17	i.	i.	PROPN
admet-376	506	18	chan	chan	PROPN
admet-376	506	19	,	,	PUNCT
admet-376	506	20	s.	s.	PROPN
admet-376	506	21	eghbali	eghbali	PROPN
admet-376	506	22	,	,	PUNCT
admet-376	506	23	r.	r.	PROPN
admet-376	506	24	rucker	rucker	PROPN
admet-376	506	25	.	.	PUNCT
admet-376	506	26	pyrroloquinoline	pyrroloquinoline	PROPN
admet-376	506	27	quinone	quinone	NOUN
admet-376	506	28	improves	improve	VERB
admet-376	506	29	growth	growth	NOUN
admet-376	506	30	and	and	CCONJ
admet-376	506	31	reproductive	reproductive	ADJ
admet-376	506	32	performance	performance	NOUN
admet-376	506	33	in	in	ADP
admet-376	506	34	mice	mouse	NOUN
admet-376	506	35	fed	feed	VERB
admet-376	506	36	chemically	chemically	ADV
admet-376	506	37	defined	define	VERB
admet-376	506	38	diets	diet	NOUN
admet-376	506	39	,	,	PUNCT
admet-376	506	40	exp	exp	NOUN
admet-376	506	41	biol	biol	PROPN
admet-376	506	42	med	med	PROPN
admet-376	506	43	(	(	PUNCT
admet-376	506	44	maywood	maywood	PROPN
admet-376	506	45	)	)	PUNCT
admet-376	506	46	228	228	NUM
admet-376	506	47	(	(	PUNCT
admet-376	506	48	2003	2003	NUM
admet-376	506	49	)	)	PUNCT
admet-376	506	50	160	160	NUM
admet-376	506	51	-	-	SYM
admet-376	506	52	166	166	NUM
admet-376	506	53	.	.	PUNCT
admet-376	507	1	[	[	X
admet-376	507	2	97	97	NUM
admet-376	507	3	]	]	PUNCT
admet-376	507	4	r.	r.	PROPN
admet-376	507	5	tao	tao	PROPN
admet-376	507	6	,	,	PUNCT
admet-376	507	7	j.s	j.s	PROPN
admet-376	507	8	.	.	PROPN
admet-376	507	9	karliner	karliner	PROPN
admet-376	507	10	,	,	PUNCT
admet-376	507	11	u.	u.	PROPN
admet-376	507	12	simonis	simonis	PROPN
admet-376	507	13	,	,	PUNCT
admet-376	507	14	j.	j.	PROPN
admet-376	507	15	zheng	zheng	PROPN
admet-376	507	16	,	,	PUNCT
admet-376	507	17	j.	j.	PROPN
admet-376	507	18	zhang	zhang	PROPN
admet-376	507	19	,	,	PUNCT
admet-376	507	20	n.	n.	PROPN
admet-376	507	21	honbo	honbo	PROPN
admet-376	507	22	,	,	PUNCT
admet-376	507	23	c.c	c.c	PROPN
admet-376	507	24	.	.	PROPN
admet-376	507	25	alano	alano	PROPN
admet-376	507	26	.	.	PUNCT
admet-376	508	1	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	508	2	quinone	quinone	NOUN
admet-376	508	3	preserves	preserve	VERB
admet-376	508	4	mitochondrial	mitochondrial	ADJ
admet-376	508	5	function	function	NOUN
admet-376	508	6	and	and	CCONJ
admet-376	508	7	prevents	prevent	VERB
admet-376	508	8	oxidative	oxidative	ADJ
admet-376	508	9	injury	injury	NOUN
admet-376	508	10	in	in	ADP
admet-376	508	11	adult	adult	NOUN
admet-376	508	12	rat	rat	NOUN
admet-376	508	13	cardiac	cardiac	ADJ
admet-376	508	14	myocytes	myocyte	NOUN
admet-376	508	15	,	,	PUNCT
admet-376	508	16	biochem	biochem	PROPN
admet-376	508	17	biophys	biophy	VERB
admet-376	508	18	res	re	NOUN
admet-376	508	19	commun	commun	PROPN
admet-376	508	20	363	363	NUM
admet-376	508	21	(	(	PUNCT
admet-376	508	22	2007	2007	NUM
admet-376	508	23	)	)	PUNCT
admet-376	508	24	257	257	NUM
admet-376	508	25	-	-	SYM
admet-376	508	26	262	262	NUM
admet-376	508	27	.	.	PUNCT
admet-376	509	1	[	[	X
admet-376	509	2	98	98	NUM
admet-376	509	3	]	]	X
admet-376	509	4	r.	r.	PROPN
admet-376	509	5	rucker	rucker	PROPN
admet-376	509	6	,	,	PUNCT
admet-376	509	7	w.	w.	PROPN
admet-376	509	8	chowanadisai	chowanadisai	PROPN
admet-376	509	9	,	,	PUNCT
admet-376	509	10	m.	m.	PROPN
admet-376	509	11	nakano	nakano	PROPN
admet-376	509	12	.	.	PUNCT
admet-376	510	1	potential	potential	ADJ
admet-376	510	2	physiological	physiological	ADJ
admet-376	510	3	importance	importance	NOUN
admet-376	510	4	of	of	ADP
admet-376	510	5	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	510	6	quinone	quinone	NOUN
admet-376	510	7	,	,	PUNCT
admet-376	510	8	altern	altern	PROPN
admet-376	510	9	med	med	PROPN
admet-376	510	10	rev	rev	VERB
admet-376	510	11	14	14	NUM
admet-376	510	12	(	(	PUNCT
admet-376	510	13	2009	2009	NUM
admet-376	510	14	)	)	PUNCT
admet-376	510	15	268	268	NUM
admet-376	510	16	-	-	SYM
admet-376	510	17	277	277	NUM
admet-376	510	18	.	.	PUNCT
admet-376	511	1	[	[	X
admet-376	511	2	99	99	NUM
admet-376	511	3	]	]	X
admet-376	511	4	h.s	h.s	PROPN
admet-376	511	5	.	.	PROPN
admet-376	511	6	misra	misra	PROPN
admet-376	511	7	,	,	PUNCT
admet-376	511	8	y.s	y.s	PROPN
admet-376	511	9	.	.	PROPN
admet-376	511	10	rajpurohit	rajpurohit	PROPN
admet-376	511	11	,	,	PUNCT
admet-376	511	12	n.p	n.p	PROPN
admet-376	511	13	.	.	PROPN
admet-376	511	14	khairnar	khairnar	PROPN
admet-376	511	15	.	.	PUNCT
admet-376	512	1	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	512	2	-	-	PUNCT
admet-376	512	3	quinone	quinone	NOUN
admet-376	512	4	and	and	CCONJ
admet-376	512	5	its	its	PRON
admet-376	512	6	versatile	versatile	ADJ
admet-376	512	7	roles	role	NOUN
admet-376	512	8	in	in	ADP
admet-376	512	9	biological	biological	ADJ
admet-376	512	10	processes	process	NOUN
admet-376	512	11	,	,	PUNCT
admet-376	512	12	journal	journal	NOUN
admet-376	512	13	of	of	ADP
admet-376	512	14	biosciences	bioscience	NOUN
admet-376	512	15	37	37	NUM
admet-376	512	16	(	(	PUNCT
admet-376	512	17	2012	2012	NUM
admet-376	512	18	)	)	PUNCT
admet-376	512	19	313	313	NUM
admet-376	512	20	-	-	SYM
admet-376	512	21	325	325	NUM
admet-376	512	22	.	.	PUNCT
admet-376	513	1	[	[	X
admet-376	513	2	100	100	NUM
admet-376	513	3	]	]	X
admet-376	513	4	c.b	c.b	PROPN
admet-376	513	5	.	.	PROPN
admet-376	513	6	harris	harris	PROPN
admet-376	513	7	,	,	PUNCT
admet-376	513	8	w.	w.	PROPN
admet-376	513	9	chowanadisai	chowanadisai	PROPN
admet-376	513	10	,	,	PUNCT
admet-376	513	11	d.o	d.o	PROPN
admet-376	513	12	.	.	PROPN
admet-376	513	13	mishchuk	mishchuk	PROPN
admet-376	513	14	,	,	PUNCT
admet-376	513	15	m.a	m.a	PROPN
admet-376	513	16	.	.	PROPN
admet-376	513	17	satre	satre	PROPN
admet-376	513	18	,	,	PUNCT
admet-376	513	19	c.m	c.m	PROPN
admet-376	513	20	.	.	PROPN
admet-376	513	21	slupsky	slupsky	PROPN
admet-376	513	22	,	,	PUNCT
admet-376	513	23	r.b	r.b	PROPN
admet-376	513	24	.	.	PROPN
admet-376	513	25	rucker	rucker	PROPN
admet-376	513	26	.	.	PUNCT
admet-376	514	1	dietary	dietary	ADJ
admet-376	514	2	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	514	3	quinone	quinone	NOUN
admet-376	514	4	(	(	PUNCT
admet-376	514	5	pqq	pqq	NOUN
admet-376	514	6	)	)	PUNCT
admet-376	514	7	alters	alter	VERB
admet-376	514	8	indicators	indicator	NOUN
admet-376	514	9	of	of	ADP
admet-376	514	10	inflammation	inflammation	NOUN
admet-376	514	11	and	and	CCONJ
admet-376	514	12	mitochondrial	mitochondrial	ADJ
admet-376	514	13	-	-	PUNCT
admet-376	514	14	related	relate	VERB
admet-376	514	15	metabolism	metabolism	NOUN
admet-376	514	16	in	in	ADP
admet-376	514	17	human	human	ADJ
admet-376	514	18	subjects	subject	NOUN
admet-376	514	19	,	,	PUNCT
admet-376	514	20	j	j	PROPN
admet-376	514	21	nutr	nutr	PROPN
admet-376	514	22	biochem	biochem	PROPN
admet-376	514	23	24	24	NUM
admet-376	514	24	(	(	PUNCT
admet-376	514	25	2013	2013	NUM
admet-376	514	26	)	)	PUNCT
admet-376	514	27	2076	2076	NUM
admet-376	514	28	-	-	PUNCT
admet-376	514	29	2084	2084	NUM
admet-376	514	30	.	.	PUNCT
admet-376	515	1	[	[	X
admet-376	515	2	101	101	NUM
admet-376	515	3	]	]	PUNCT
admet-376	515	4	m.	m.	NOUN
admet-376	515	5	akagawa	akagawa	PROPN
admet-376	515	6	,	,	PUNCT
admet-376	515	7	m.	m.	PROPN
admet-376	515	8	nakano	nakano	PROPN
admet-376	515	9	,	,	PUNCT
admet-376	515	10	k.	k.	PROPN
admet-376	515	11	ikemoto	ikemoto	PROPN
admet-376	515	12	.	.	PUNCT
admet-376	516	1	recent	recent	ADJ
admet-376	516	2	progress	progress	NOUN
admet-376	516	3	in	in	ADP
admet-376	516	4	studies	study	NOUN
admet-376	516	5	on	on	ADP
admet-376	516	6	the	the	DET
admet-376	516	7	health	health	NOUN
admet-376	516	8	benefits	benefit	NOUN
admet-376	516	9	of	of	ADP
admet-376	516	10	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	516	11	quinone	quinone	NOUN
admet-376	516	12	,	,	PUNCT
admet-376	516	13	biosci	biosci	PROPN
admet-376	516	14	biotechnol	biotechnol	PROPN
admet-376	516	15	biochem	biochem	NOUN
admet-376	516	16	80	80	NUM
admet-376	516	17	(	(	PUNCT
admet-376	516	18	2015	2015	NUM
admet-376	516	19	)	)	PUNCT
admet-376	516	20	13	13	NUM
admet-376	516	21	-	-	SYM
admet-376	516	22	22	22	NUM
admet-376	516	23	.	.	PUNCT
admet-376	517	1	[	[	X
admet-376	517	2	102	102	NUM
admet-376	517	3	]	]	X
admet-376	517	4	n.	n.	PROPN
admet-376	517	5	kumar	kumar	PROPN
admet-376	517	6	,	,	PUNCT
admet-376	517	7	a.	a.	PROPN
admet-376	517	8	kar	kar	PROPN
admet-376	517	9	.	.	PUNCT
admet-376	518	1	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	518	2	quinone	quinone	NOUN
admet-376	518	3	(	(	PUNCT
admet-376	518	4	pqq	pqq	NOUN
admet-376	518	5	)	)	PUNCT
admet-376	518	6	has	have	VERB
admet-376	518	7	potential	potential	NOUN
admet-376	518	8	to	to	PART
admet-376	518	9	ameliorate	ameliorate	VERB
admet-376	518	10	streptozotocin	streptozotocin	NOUN
admet-376	518	11	-	-	PUNCT
admet-376	518	12	induced	induce	VERB
admet-376	518	13	diabetes	diabetes	NOUN
admet-376	518	14	mellitus	mellitus	NOUN
admet-376	518	15	and	and	CCONJ
admet-376	518	16	oxidative	oxidative	ADJ
admet-376	518	17	stress	stress	NOUN
admet-376	518	18	in	in	ADP
admet-376	518	19	mice	mouse	NOUN
admet-376	518	20	:	:	PUNCT
admet-376	518	21	a	a	DET
admet-376	518	22	histopathological	histopathological	ADJ
admet-376	518	23	and	and	CCONJ
admet-376	518	24	biochemical	biochemical	ADJ
admet-376	518	25	study	study	NOUN
admet-376	518	26	,	,	PUNCT
admet-376	518	27	chem	chem	NOUN
admet-376	518	28	biol	biol	NOUN
admet-376	518	29	interact	interact	VERB
admet-376	518	30	240	240	NUM
admet-376	518	31	(	(	PUNCT
admet-376	518	32	2015	2015	NUM
admet-376	518	33	)	)	PUNCT
admet-376	518	34	278	278	NUM
admet-376	518	35	-	-	SYM
admet-376	518	36	290	290	NUM
admet-376	518	37	.	.	PUNCT
admet-376	519	1	admet	admet	PROPN
admet-376	519	2	&	&	CCONJ
admet-376	519	3	dmpk	dmpk	PROPN
admet-376	519	4	5(2	5(2	NUM
admet-376	519	5	)	)	PUNCT
admet-376	519	6	(	(	PUNCT
admet-376	519	7	2017	2017	NUM
admet-376	519	8	)	)	PUNCT
admet-376	519	9	85	85	NUM
admet-376	519	10	-	-	SYM
admet-376	519	11	125	125	NUM
admet-376	519	12	exogenous	exogenous	ADJ
admet-376	519	13	natural	natural	ADJ
admet-376	519	14	products	product	NOUN
admet-376	519	15	as	as	ADP
admet-376	519	16	‘	'	PUNCT
admet-376	519	17	natural	natural	ADJ
admet-376	519	18	’	'	PUNCT
admet-376	519	19	drug	drug	NOUN
admet-376	519	20	transporter	transporter	NOUN
admet-376	519	21	substrates	substrate	VERB
admet-376	519	22	doi	doi	NOUN
admet-376	519	23	:	:	PUNCT
admet-376	519	24	10.5599	10.5599	NUM
admet-376	519	25	/	/	SYM
admet-376	519	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	519	27	119	119	NUM
admet-376	520	1	[	[	X
admet-376	520	2	103	103	NUM
admet-376	520	3	]	]	PUNCT
admet-376	520	4	j.	j.	PROPN
admet-376	520	5	qin	qin	PROPN
admet-376	520	6	,	,	PUNCT
admet-376	520	7	m.	m.	PROPN
admet-376	520	8	wu	wu	PROPN
admet-376	520	9	,	,	PUNCT
admet-376	520	10	s.	s.	PROPN
admet-376	520	11	yu	yu	PROPN
admet-376	520	12	,	,	PUNCT
admet-376	520	13	x.	x.	PROPN
admet-376	520	14	gao	gao	PROPN
admet-376	520	15	,	,	PUNCT
admet-376	520	16	j.	j.	PROPN
admet-376	520	17	zhang	zhang	PROPN
admet-376	520	18	,	,	PUNCT
admet-376	520	19	x.	x.	PROPN
admet-376	520	20	dong	dong	PROPN
admet-376	520	21	,	,	PUNCT
admet-376	520	22	j.	j.	PROPN
admet-376	520	23	ji	ji	PROPN
admet-376	520	24	,	,	PUNCT
admet-376	520	25	y.	y.	PROPN
admet-376	520	26	zhang	zhang	PROPN
admet-376	520	27	,	,	PUNCT
admet-376	520	28	l.	l.	PROPN
admet-376	520	29	zhou	zhou	PROPN
admet-376	520	30	,	,	PUNCT
admet-376	520	31	q.	q.	PROPN
admet-376	520	32	zhang	zhang	PROPN
admet-376	520	33	,	,	PUNCT
admet-376	520	34	f.	f.	PROPN
admet-376	520	35	ding	ding	PROPN
admet-376	520	36	.	.	PUNCT
admet-376	521	1	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	521	2	quinone	quinone	NOUN
admet-376	521	3	-	-	PUNCT
admet-376	521	4	conferred	confer	VERB
admet-376	521	5	neuroprotection	neuroprotection	NOUN
admet-376	521	6	in	in	ADP
admet-376	521	7	rotenone	rotenone	NOUN
admet-376	521	8	models	model	NOUN
admet-376	521	9	of	of	ADP
admet-376	521	10	parkinson	parkinson	NOUN
admet-376	521	11	's	's	PART
admet-376	521	12	disease	disease	NOUN
admet-376	521	13	,	,	PUNCT
admet-376	521	14	toxicol	toxicol	PROPN
admet-376	521	15	lett	lett	NOUN
admet-376	521	16	238	238	NUM
admet-376	521	17	(	(	PUNCT
admet-376	521	18	2015	2015	NUM
admet-376	521	19	)	)	PUNCT
admet-376	521	20	70	70	NUM
admet-376	521	21	-	-	SYM
admet-376	521	22	82	82	NUM
admet-376	521	23	.	.	PUNCT
admet-376	522	1	[	[	X
admet-376	522	2	104	104	X
admet-376	522	3	]	]	X
admet-376	522	4	k.r	k.r	PROPN
admet-376	522	5	.	.	PROPN
admet-376	522	6	jonscher	jonscher	PROPN
admet-376	522	7	,	,	PUNCT
admet-376	522	8	m.s	m.s	PROPN
admet-376	522	9	.	.	PROPN
admet-376	522	10	stewart	stewart	PROPN
admet-376	522	11	,	,	PUNCT
admet-376	522	12	a.	a.	PROPN
admet-376	522	13	alfonso	alfonso	PROPN
admet-376	522	14	-	-	PUNCT
admet-376	522	15	garcia	garcia	PROPN
admet-376	522	16	,	,	PUNCT
admet-376	522	17	b.c	b.c	PROPN
admet-376	522	18	.	.	PROPN
admet-376	522	19	defelice	defelice	PROPN
admet-376	522	20	,	,	PUNCT
admet-376	522	21	x.x	x.x	PROPN
admet-376	522	22	.	.	PROPN
admet-376	522	23	wang	wang	PROPN
admet-376	522	24	,	,	PUNCT
admet-376	522	25	y.	y.	PROPN
admet-376	522	26	luo	luo	PROPN
admet-376	522	27	,	,	PUNCT
admet-376	522	28	m.	m.	PROPN
admet-376	522	29	levi	levi	PROPN
admet-376	522	30	,	,	PUNCT
admet-376	522	31	m.j	m.j	PROPN
admet-376	522	32	.	.	PROPN
admet-376	522	33	heerwagen	heerwagen	PROPN
admet-376	522	34	,	,	PUNCT
admet-376	522	35	r.c	r.c	PROPN
admet-376	522	36	.	.	PROPN
admet-376	522	37	janssen	janssen	PROPN
admet-376	522	38	,	,	PUNCT
admet-376	522	39	b.a	b.a	PROPN
admet-376	522	40	.	.	PROPN
admet-376	522	41	de	de	PROPN
admet-376	522	42	la	la	PROPN
admet-376	522	43	houssaye	houssaye	PROPN
admet-376	522	44	,	,	PUNCT
admet-376	522	45	e.	e.	PROPN
admet-376	522	46	wiitala	wiitala	PROPN
admet-376	522	47	,	,	PUNCT
admet-376	522	48	g.	g.	PROPN
admet-376	522	49	florey	florey	PROPN
admet-376	522	50	,	,	PUNCT
admet-376	522	51	r.l	r.l	PROPN
admet-376	522	52	.	.	PROPN
admet-376	522	53	jonscher	jonscher	PROPN
admet-376	522	54	,	,	PUNCT
admet-376	522	55	e.o	e.o	PROPN
admet-376	522	56	.	.	PROPN
admet-376	522	57	potma	potma	PROPN
admet-376	522	58	,	,	PUNCT
admet-376	522	59	o.	o.	PROPN
admet-376	522	60	fiehn	fiehn	PROPN
admet-376	522	61	,	,	PUNCT
admet-376	522	62	j.e	j.e	PROPN
admet-376	522	63	.	.	PROPN
admet-376	522	64	friedman	friedman	PROPN
admet-376	522	65	.	.	PUNCT
admet-376	523	1	early	early	ADJ
admet-376	523	2	pqq	pqq	NOUN
admet-376	523	3	supplementation	supplementation	NOUN
admet-376	523	4	has	have	VERB
admet-376	523	5	persistent	persistent	ADJ
admet-376	523	6	long	long	ADJ
admet-376	523	7	-	-	PUNCT
admet-376	523	8	term	term	NOUN
admet-376	523	9	protective	protective	ADJ
admet-376	523	10	effects	effect	NOUN
admet-376	523	11	on	on	ADP
admet-376	523	12	developmental	developmental	ADJ
admet-376	523	13	programming	programming	NOUN
admet-376	523	14	of	of	ADP
admet-376	523	15	hepatic	hepatic	ADJ
admet-376	523	16	lipotoxicity	lipotoxicity	NOUN
admet-376	523	17	and	and	CCONJ
admet-376	523	18	inflammation	inflammation	NOUN
admet-376	523	19	in	in	ADP
admet-376	523	20	obese	obese	ADJ
admet-376	523	21	mice	mouse	NOUN
admet-376	523	22	,	,	PUNCT
admet-376	523	23	faseb	faseb	PROPN
admet-376	523	24	j	j	PROPN
admet-376	523	25	(	(	PUNCT
admet-376	523	26	2016	2016	NUM
admet-376	523	27	)	)	PUNCT
admet-376	523	28	.	.	PUNCT
admet-376	524	1	[	[	X
admet-376	524	2	105	105	NUM
admet-376	524	3	]	]	X
admet-376	524	4	q.	q.	PROPN
admet-376	524	5	zhang	zhang	PROPN
admet-376	524	6	,	,	PUNCT
admet-376	524	7	s.	s.	PROPN
admet-376	524	8	chen	chen	PROPN
admet-376	524	9	,	,	PUNCT
admet-376	524	10	s.	s.	PROPN
admet-376	524	11	yu	yu	PROPN
admet-376	524	12	,	,	PUNCT
admet-376	524	13	j.	j.	PROPN
admet-376	524	14	qin	qin	PROPN
admet-376	524	15	,	,	PUNCT
admet-376	524	16	j.	j.	PROPN
admet-376	524	17	zhang	zhang	PROPN
admet-376	524	18	,	,	PUNCT
admet-376	524	19	q.	q.	PROPN
admet-376	524	20	cheng	cheng	PROPN
admet-376	524	21	,	,	PUNCT
admet-376	524	22	k.	k.	PROPN
admet-376	524	23	ke	ke	PROPN
admet-376	524	24	,	,	PUNCT
admet-376	524	25	f.	f.	PROPN
admet-376	524	26	ding	ding	PROPN
admet-376	524	27	.	.	PUNCT
admet-376	525	1	neuroprotective	neuroprotective	ADJ
admet-376	525	2	effects	effect	NOUN
admet-376	525	3	of	of	ADP
admet-376	525	4	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	525	5	quinone	quinone	NOUN
admet-376	525	6	against	against	ADP
admet-376	525	7	rotenone	rotenone	NOUN
admet-376	525	8	injury	injury	NOUN
admet-376	525	9	in	in	ADP
admet-376	525	10	primary	primary	ADJ
admet-376	525	11	cultured	cultured	ADJ
admet-376	525	12	midbrain	midbrain	NOUN
admet-376	525	13	neurons	neuron	NOUN
admet-376	525	14	and	and	CCONJ
admet-376	525	15	in	in	ADP
admet-376	525	16	a	a	DET
admet-376	525	17	rat	rat	NOUN
admet-376	525	18	model	model	NOUN
admet-376	525	19	of	of	ADP
admet-376	525	20	parkinson	parkinson	NOUN
admet-376	525	21	's	's	PART
admet-376	525	22	disease	disease	NOUN
admet-376	525	23	,	,	PUNCT
admet-376	525	24	neuropharmacology	neuropharmacology	NOUN
admet-376	525	25	108	108	NUM
admet-376	525	26	(	(	PUNCT
admet-376	525	27	2016	2016	NUM
admet-376	525	28	)	)	PUNCT
admet-376	525	29	238	238	NUM
admet-376	525	30	-	-	SYM
admet-376	525	31	251	251	NUM
admet-376	525	32	.	.	PUNCT
admet-376	526	1	[	[	X
admet-376	526	2	106	106	X
admet-376	526	3	]	]	X
admet-376	526	4	j.z	j.z	PROPN
admet-376	526	5	.	.	PROPN
admet-376	526	6	wu	wu	PROPN
admet-376	526	7	,	,	PUNCT
admet-376	526	8	j.h	j.h	PROPN
admet-376	526	9	.	.	PROPN
admet-376	526	10	huang	huang	PROPN
admet-376	526	11	,	,	PUNCT
admet-376	526	12	r.	r.	PROPN
admet-376	526	13	khanabdali	khanabdali	PROPN
admet-376	526	14	,	,	PUNCT
admet-376	526	15	b.	b.	PROPN
admet-376	526	16	kalionis	kalionis	PROPN
admet-376	526	17	,	,	PUNCT
admet-376	526	18	s.j	s.j	PROPN
admet-376	526	19	.	.	PROPN
admet-376	526	20	xia	xia	PROPN
admet-376	526	21	,	,	PUNCT
admet-376	526	22	w.j	w.j	PROPN
admet-376	526	23	.	.	PROPN
admet-376	526	24	cai	cai	PROPN
admet-376	526	25	.	.	PUNCT
admet-376	526	26	pyrroloquinoline	pyrroloquinoline	NOUN
admet-376	526	27	quinone	quinone	NOUN
admet-376	526	28	enhances	enhance	VERB
admet-376	526	29	the	the	DET
admet-376	526	30	resistance	resistance	NOUN
admet-376	526	31	to	to	PART
admet-376	526	32	oxidative	oxidative	ADJ
admet-376	526	33	stress	stress	NOUN
admet-376	526	34	and	and	CCONJ
admet-376	526	35	extends	extend	VERB
admet-376	526	36	lifespan	lifespan	VERB
admet-376	526	37	upon	upon	SCONJ
admet-376	526	38	daf-16	daf-16	NUM
admet-376	526	39	and	and	CCONJ
admet-376	526	40	skn-1	skn-1	PUNCT
admet-376	526	41	activities	activity	NOUN
admet-376	526	42	in	in	ADP
admet-376	526	43	c.	c.	PROPN
admet-376	526	44	elegans	elegan	NOUN
admet-376	526	45	,	,	PUNCT
admet-376	526	46	exp	exp	NOUN
admet-376	526	47	gerontol	gerontol	NOUN
admet-376	526	48	80	80	NUM
admet-376	526	49	(	(	PUNCT
admet-376	526	50	2016	2016	NUM
admet-376	526	51	)	)	PUNCT
admet-376	526	52	43	43	NUM
admet-376	526	53	-	-	SYM
admet-376	526	54	50	50	NUM
admet-376	526	55	.	.	PUNCT
admet-376	527	1	[	[	X
admet-376	527	2	107	107	NUM
admet-376	527	3	]	]	X
admet-376	527	4	s.a	s.a	PROPN
admet-376	527	5	.	.	PROPN
admet-376	527	6	salisbury	salisbury	PROPN
admet-376	527	7	,	,	PUNCT
admet-376	527	8	h.s	h.s	PROPN
admet-376	527	9	.	.	PROPN
admet-376	527	10	forrest	forrest	PROPN
admet-376	527	11	,	,	PUNCT
admet-376	527	12	w.b	w.b	PROPN
admet-376	527	13	.	.	PROPN
admet-376	527	14	cruse	cruse	PROPN
admet-376	527	15	,	,	PUNCT
admet-376	527	16	o.	o.	PROPN
admet-376	527	17	kennard	kennard	PROPN
admet-376	527	18	.	.	PUNCT
admet-376	528	1	a	a	DET
admet-376	528	2	novel	novel	ADJ
admet-376	528	3	coenzyme	coenzyme	NOUN
admet-376	528	4	from	from	ADP
admet-376	528	5	bacterial	bacterial	ADJ
admet-376	528	6	primary	primary	ADJ
admet-376	528	7	alcohol	alcohol	NOUN
admet-376	528	8	dehydrogenases	dehydrogenase	NOUN
admet-376	528	9	,	,	PUNCT
admet-376	528	10	nature	nature	NOUN
admet-376	528	11	280	280	NUM
admet-376	528	12	(	(	PUNCT
admet-376	528	13	1979	1979	NUM
admet-376	528	14	)	)	PUNCT
admet-376	528	15	843	843	NUM
admet-376	528	16	-	-	SYM
admet-376	528	17	844	844	NUM
admet-376	528	18	.	.	PUNCT
admet-376	529	1	[	[	X
admet-376	529	2	108	108	NUM
admet-376	529	3	]	]	X
admet-376	529	4	j.a	j.a	PROPN
admet-376	529	5	.	.	PROPN
admet-376	529	6	duine	duine	PROPN
admet-376	529	7	.	.	PUNCT
admet-376	530	1	pqq	pqq	VERB
admet-376	530	2	and	and	CCONJ
admet-376	530	3	quinoprotein	quinoprotein	ADJ
admet-376	530	4	research	research	NOUN
admet-376	530	5	--	--	PUNCT
admet-376	530	6	the	the	DET
admet-376	530	7	first	first	ADJ
admet-376	530	8	decade	decade	NOUN
admet-376	530	9	,	,	PUNCT
admet-376	530	10	biofactors	biofactor	NOUN
admet-376	530	11	2	2	NUM
admet-376	530	12	(	(	PUNCT
admet-376	530	13	1989	1989	NUM
admet-376	530	14	)	)	PUNCT
admet-376	530	15	87	87	NUM
admet-376	530	16	-	-	SYM
admet-376	530	17	94	94	NUM
admet-376	530	18	.	.	PUNCT
admet-376	531	1	[	[	X
admet-376	531	2	109	109	NUM
admet-376	531	3	]	]	PUNCT
admet-376	531	4	c.	c.	PROPN
admet-376	531	5	anthony	anthony	PROPN
admet-376	531	6	.	.	PUNCT
admet-376	531	7	pyrroloquinoline	pyrroloquinoline	PROPN
admet-376	531	8	quinone	quinone	NOUN
admet-376	531	9	(	(	PUNCT
admet-376	531	10	pqq	pqq	NOUN
admet-376	531	11	)	)	PUNCT
admet-376	531	12	and	and	CCONJ
admet-376	531	13	quinoprotein	quinoprotein	ADJ
admet-376	531	14	enzymes	enzyme	NOUN
admet-376	531	15	,	,	PUNCT
admet-376	531	16	antioxid	antioxid	VERB
admet-376	531	17	redox	redox	NOUN
admet-376	531	18	signal	signal	NOUN
admet-376	531	19	3	3	NUM
admet-376	531	20	(	(	PUNCT
admet-376	531	21	2001	2001	NUM
admet-376	531	22	)	)	PUNCT
admet-376	531	23	757	757	PROPN
admet-376	531	24	-	-	PUNCT
admet-376	531	25	774	774	NUM
admet-376	531	26	.	.	PUNCT
admet-376	532	1	[	[	X
admet-376	532	2	110	110	NUM
admet-376	532	3	]	]	PUNCT
admet-376	532	4	m.	m.	NOUN
admet-376	532	5	vogt	vogt	PROPN
admet-376	532	6	,	,	PUNCT
admet-376	532	7	j.	j.	PROPN
admet-376	532	8	bajorath	bajorath	PROPN
admet-376	532	9	.	.	PUNCT
admet-376	533	1	introduction	introduction	NOUN
admet-376	533	2	of	of	ADP
admet-376	533	3	the	the	DET
admet-376	533	4	conditional	conditional	ADJ
admet-376	533	5	correlated	correlate	VERB
admet-376	533	6	bernoulli	bernoulli	PROPN
admet-376	533	7	model	model	NOUN
admet-376	533	8	of	of	ADP
admet-376	533	9	similarity	similarity	NOUN
admet-376	533	10	value	value	NOUN
admet-376	533	11	distributions	distribution	NOUN
admet-376	533	12	and	and	CCONJ
admet-376	533	13	its	its	PRON
admet-376	533	14	application	application	NOUN
admet-376	533	15	to	to	ADP
admet-376	533	16	the	the	DET
admet-376	533	17	prospective	prospective	ADJ
admet-376	533	18	prediction	prediction	NOUN
admet-376	533	19	of	of	ADP
admet-376	533	20	fingerprint	fingerprint	NOUN
admet-376	533	21	search	search	NOUN
admet-376	533	22	performance	performance	NOUN
admet-376	533	23	,	,	PUNCT
admet-376	533	24	j	j	PROPN
admet-376	533	25	chem	chem	PROPN
admet-376	533	26	inf	inf	PROPN
admet-376	533	27	model	model	NOUN
admet-376	533	28	51	51	NUM
admet-376	533	29	(	(	PUNCT
admet-376	533	30	2011	2011	NUM
admet-376	533	31	)	)	PUNCT
admet-376	533	32	2496	2496	NUM
admet-376	533	33	-	-	SYM
admet-376	533	34	2506	2506	NUM
admet-376	533	35	.	.	PUNCT
admet-376	534	1	[	[	X
admet-376	534	2	111	111	NUM
admet-376	534	3	]	]	PUNCT
admet-376	534	4	m.	m.	NOUN
admet-376	534	5	vogt	vogt	PROPN
admet-376	534	6	,	,	PUNCT
admet-376	534	7	j.	j.	PROPN
admet-376	534	8	bajorath	bajorath	PROPN
admet-376	534	9	.	.	PUNCT
admet-376	535	1	predicting	predict	VERB
admet-376	535	2	the	the	DET
admet-376	535	3	performance	performance	NOUN
admet-376	535	4	of	of	ADP
admet-376	535	5	fingerprint	fingerprint	NOUN
admet-376	535	6	similarity	similarity	NOUN
admet-376	535	7	searching	searching	NOUN
admet-376	535	8	,	,	PUNCT
admet-376	535	9	methods	method	NOUN
admet-376	535	10	mol	mol	ADP
admet-376	535	11	biol	biol	PROPN
admet-376	535	12	672	672	NUM
admet-376	535	13	(	(	PUNCT
admet-376	535	14	2011	2011	NUM
admet-376	535	15	)	)	PUNCT
admet-376	535	16	159	159	NUM
admet-376	535	17	-	-	SYM
admet-376	535	18	173	173	NUM
admet-376	535	19	.	.	PUNCT
admet-376	536	1	[	[	X
admet-376	536	2	112	112	NUM
admet-376	536	3	]	]	PUNCT
admet-376	536	4	v.	v.	CCONJ
admet-376	536	5	hähnke	hähnke	NOUN
admet-376	536	6	,	,	PUNCT
admet-376	536	7	m.	m.	NOUN
admet-376	536	8	rupp	rupp	PROPN
admet-376	536	9	,	,	PUNCT
admet-376	536	10	a.k	a.k	PROPN
admet-376	536	11	.	.	PROPN
admet-376	536	12	hartmann	hartmann	PROPN
admet-376	536	13	,	,	PUNCT
admet-376	536	14	g.	g.	PROPN
admet-376	536	15	schneider	schneider	PROPN
admet-376	536	16	.	.	PUNCT
admet-376	537	1	pharmacophore	pharmacophore	ADJ
admet-376	537	2	alignment	alignment	NOUN
admet-376	537	3	search	search	NOUN
admet-376	537	4	tool	tool	NOUN
admet-376	537	5	(	(	PUNCT
admet-376	537	6	phast	phast	NOUN
admet-376	537	7	):	):	PUNCT
admet-376	537	8	significance	significance	NOUN
admet-376	537	9	assessment	assessment	NOUN
admet-376	537	10	of	of	ADP
admet-376	537	11	chemical	chemical	ADJ
admet-376	537	12	similarity	similarity	NOUN
admet-376	537	13	,	,	PUNCT
admet-376	537	14	mol	mol	ADP
admet-376	537	15	inform	inform	NOUN
admet-376	537	16	32	32	NUM
admet-376	537	17	(	(	PUNCT
admet-376	537	18	2013	2013	NUM
admet-376	537	19	)	)	PUNCT
admet-376	537	20	625	625	NUM
admet-376	537	21	-	-	SYM
admet-376	537	22	646	646	NUM
admet-376	537	23	.	.	PUNCT
admet-376	538	1	[	[	X
admet-376	538	2	113	113	NUM
admet-376	538	3	]	]	PUNCT
admet-376	538	4	s.	s.	PROPN
admet-376	538	5	riniker	riniker	PROPN
admet-376	538	6	,	,	PUNCT
admet-376	538	7	g.a	g.a	PROPN
admet-376	538	8	.	.	PROPN
admet-376	538	9	landrum	landrum	PROPN
admet-376	538	10	.	.	PUNCT
admet-376	539	1	open	open	ADJ
admet-376	539	2	-	-	PUNCT
admet-376	539	3	source	source	NOUN
admet-376	539	4	platform	platform	NOUN
admet-376	539	5	to	to	ADP
admet-376	539	6	benchmark	benchmark	NOUN
admet-376	539	7	fingerprints	fingerprint	NOUN
admet-376	539	8	for	for	ADP
admet-376	539	9	ligand	ligand	NOUN
admet-376	539	10	-	-	PUNCT
admet-376	539	11	based	base	VERB
admet-376	539	12	virtual	virtual	ADJ
admet-376	539	13	screening	screening	NOUN
admet-376	539	14	,	,	PUNCT
admet-376	539	15	j	j	PROPN
admet-376	539	16	cheminform	cheminform	PROPN
admet-376	539	17	5	5	NUM
admet-376	539	18	(	(	PUNCT
admet-376	539	19	2013	2013	NUM
admet-376	539	20	)	)	PUNCT
admet-376	539	21	26	26	NUM
admet-376	539	22	.	.	PUNCT
admet-376	540	1	[	[	X
admet-376	540	2	114	114	NUM
admet-376	540	3	]	]	SYM
admet-376	540	4	n.m	n.m	PROPN
admet-376	540	5	.	.	PROPN
admet-376	540	6	o'boyle	o'boyle	PROPN
admet-376	540	7	,	,	PUNCT
admet-376	540	8	r.a	r.a	PROPN
admet-376	540	9	.	.	PROPN
admet-376	540	10	sayle	sayle	PROPN
admet-376	540	11	.	.	PUNCT
admet-376	541	1	comparing	compare	VERB
admet-376	541	2	structural	structural	ADJ
admet-376	541	3	fingerprints	fingerprint	NOUN
admet-376	541	4	using	use	VERB
admet-376	541	5	a	a	DET
admet-376	541	6	literature	literature	NOUN
admet-376	541	7	-	-	PUNCT
admet-376	541	8	based	base	VERB
admet-376	541	9	similarity	similarity	NOUN
admet-376	541	10	benchmark	benchmark	NOUN
admet-376	541	11	,	,	PUNCT
admet-376	541	12	j	j	PROPN
admet-376	541	13	cheminform	cheminform	PROPN
admet-376	541	14	8	8	NUM
admet-376	541	15	(	(	PUNCT
admet-376	541	16	2016	2016	NUM
admet-376	541	17	)	)	PUNCT
admet-376	541	18	36	36	NUM
admet-376	541	19	.	.	PUNCT
admet-376	542	1	[	[	X
admet-376	542	2	115	115	NUM
admet-376	542	3	]	]	PUNCT
admet-376	542	4	s.	s.	PROPN
admet-376	542	5	o'hagan	o'hagan	PROPN
admet-376	542	6	,	,	PUNCT
admet-376	542	7	d.b	d.b	PROPN
admet-376	542	8	.	.	PROPN
admet-376	542	9	kell	kell	PROPN
admet-376	542	10	.	.	PUNCT
admet-376	543	1	analysis	analysis	NOUN
admet-376	543	2	of	of	ADP
admet-376	543	3	drug	drug	NOUN
admet-376	543	4	-	-	PUNCT
admet-376	543	5	endogenous	endogenous	ADJ
admet-376	543	6	human	human	ADJ
admet-376	543	7	metabolite	metabolite	NOUN
admet-376	543	8	similarities	similarity	NOUN
admet-376	543	9	in	in	ADP
admet-376	543	10	terms	term	NOUN
admet-376	543	11	of	of	ADP
admet-376	543	12	their	their	PRON
admet-376	543	13	maximum	maximum	ADJ
admet-376	543	14	common	common	ADJ
admet-376	543	15	substructures	substructure	NOUN
admet-376	543	16	,	,	PUNCT
admet-376	543	17	j	j	PROPN
admet-376	543	18	cheminform	cheminform	PROPN
admet-376	543	19	9	9	NUM
admet-376	543	20	(	(	PUNCT
admet-376	543	21	2017	2017	NUM
admet-376	543	22	)	)	PUNCT
admet-376	543	23	18	18	NUM
admet-376	543	24	.	.	PUNCT
admet-376	544	1	[	[	X
admet-376	544	2	116	116	X
admet-376	544	3	]	]	X
admet-376	544	4	a.l	a.l	PROPN
admet-376	544	5	.	.	PROPN
admet-376	544	6	harvey	harvey	PROPN
admet-376	544	7	,	,	PUNCT
admet-376	544	8	r.	r.	PROPN
admet-376	544	9	edrada	edrada	PROPN
admet-376	544	10	-	-	PUNCT
admet-376	544	11	ebel	ebel	PROPN
admet-376	544	12	,	,	PUNCT
admet-376	544	13	r.j	r.j	PROPN
admet-376	544	14	.	.	PROPN
admet-376	544	15	quinn	quinn	PROPN
admet-376	544	16	.	.	PUNCT
admet-376	545	1	the	the	DET
admet-376	545	2	re	re	NOUN
admet-376	545	3	-	-	NOUN
admet-376	545	4	emergence	emergence	NOUN
admet-376	545	5	of	of	ADP
admet-376	545	6	natural	natural	ADJ
admet-376	545	7	products	product	NOUN
admet-376	545	8	for	for	ADP
admet-376	545	9	drug	drug	NOUN
admet-376	545	10	discovery	discovery	NOUN
admet-376	545	11	in	in	ADP
admet-376	545	12	the	the	DET
admet-376	545	13	genomics	genomics	NOUN
admet-376	545	14	era	era	NOUN
admet-376	545	15	,	,	PUNCT
admet-376	545	16	nat	nat	PROPN
admet-376	545	17	rev	rev	VERB
admet-376	545	18	drug	drug	PROPN
admet-376	545	19	discov	discov	PROPN
admet-376	545	20	14	14	NUM
admet-376	545	21	(	(	PUNCT
admet-376	545	22	2015	2015	NUM
admet-376	545	23	)	)	PUNCT
admet-376	545	24	111	111	NUM
admet-376	545	25	-	-	SYM
admet-376	545	26	129	129	NUM
admet-376	545	27	.	.	PUNCT
admet-376	546	1	[	[	X
admet-376	546	2	117	117	NUM
admet-376	546	3	]	]	PUNCT
admet-376	546	4	m.	m.	NOUN
admet-376	546	5	füllbeck	füllbeck	PROPN
admet-376	546	6	,	,	PUNCT
admet-376	546	7	e.	e.	PROPN
admet-376	546	8	michalsky	michalsky	PROPN
admet-376	546	9	,	,	PUNCT
admet-376	546	10	m.	m.	NOUN
admet-376	546	11	dunkel	dunkel	NOUN
admet-376	546	12	,	,	PUNCT
admet-376	546	13	r.	r.	PROPN
admet-376	546	14	preissner	preissner	PROPN
admet-376	546	15	.	.	PUNCT
admet-376	547	1	natural	natural	ADJ
admet-376	547	2	products	product	NOUN
admet-376	547	3	:	:	PUNCT
admet-376	547	4	sources	source	NOUN
admet-376	547	5	and	and	CCONJ
admet-376	547	6	databases	database	NOUN
admet-376	547	7	,	,	PUNCT
admet-376	547	8	nat	nat	PROPN
admet-376	547	9	prod	prod	PROPN
admet-376	547	10	rep	rep	PROPN
admet-376	547	11	23	23	NUM
admet-376	547	12	(	(	PUNCT
admet-376	547	13	2006	2006	NUM
admet-376	547	14	)	)	PUNCT
admet-376	547	15	347	347	NUM
admet-376	547	16	-	-	SYM
admet-376	547	17	356	356	NUM
admet-376	547	18	.	.	PUNCT
admet-376	548	1	[	[	X
admet-376	548	2	118	118	NUM
admet-376	548	3	]	]	X
admet-376	548	4	s.r	s.r	PROPN
admet-376	548	5	.	.	PROPN
admet-376	548	6	johnson	johnson	PROPN
admet-376	548	7	,	,	PUNCT
admet-376	548	8	b.m	b.m	PROPN
admet-376	548	9	.	.	PROPN
admet-376	548	10	lange	lange	PROPN
admet-376	548	11	.	.	PUNCT
admet-376	548	12	open	open	ADJ
admet-376	548	13	-	-	PUNCT
admet-376	548	14	access	access	NOUN
admet-376	548	15	metabolomics	metabolomic	NOUN
admet-376	548	16	databases	database	NOUN
admet-376	548	17	for	for	ADP
admet-376	548	18	natural	natural	ADJ
admet-376	548	19	product	product	NOUN
admet-376	548	20	research	research	NOUN
admet-376	548	21	:	:	PUNCT
admet-376	548	22	present	present	ADJ
admet-376	548	23	capabilities	capability	NOUN
admet-376	548	24	and	and	CCONJ
admet-376	548	25	future	future	ADJ
admet-376	548	26	potential	potential	NOUN
admet-376	548	27	,	,	PUNCT
admet-376	548	28	front	front	ADJ
admet-376	548	29	bioeng	bioeng	PROPN
admet-376	548	30	biotechnol	biotechnol	NOUN
admet-376	548	31	3	3	NUM
admet-376	548	32	(	(	PUNCT
admet-376	548	33	2015	2015	NUM
admet-376	548	34	)	)	PUNCT
admet-376	548	35	22	22	NUM
admet-376	548	36	.	.	PUNCT
admet-376	549	1	[	[	X
admet-376	549	2	119	119	NUM
admet-376	549	3	]	]	X
admet-376	549	4	c.w	c.w	PROPN
admet-376	549	5	.	.	PROPN
admet-376	549	6	tung	tung	PROPN
admet-376	549	7	.	.	PUNCT
admet-376	550	1	public	public	ADJ
admet-376	550	2	databases	database	NOUN
admet-376	550	3	of	of	ADP
admet-376	550	4	plant	plant	NOUN
admet-376	550	5	natural	natural	ADJ
admet-376	550	6	products	product	NOUN
admet-376	550	7	for	for	ADP
admet-376	550	8	computational	computational	ADJ
admet-376	550	9	drug	drug	NOUN
admet-376	550	10	discovery	discovery	NOUN
admet-376	550	11	,	,	PUNCT
admet-376	550	12	curr	curr	PROPN
admet-376	550	13	comput	comput	PROPN
admet-376	550	14	aided	aid	VERB
admet-376	550	15	drug	drug	NOUN
admet-376	550	16	des	des	X
admet-376	550	17	10	10	NUM
admet-376	550	18	(	(	PUNCT
admet-376	550	19	2014	2014	NUM
admet-376	550	20	)	)	PUNCT
admet-376	550	21	191	191	NUM
admet-376	550	22	-	-	SYM
admet-376	550	23	196	196	NUM
admet-376	550	24	.	.	PUNCT
admet-376	551	1	[	[	X
admet-376	551	2	120	120	NUM
admet-376	551	3	]	]	SYM
admet-376	551	4	a.b	a.b	PROPN
admet-376	551	5	.	.	PROPN
admet-376	551	6	yongye	yongye	PROPN
admet-376	551	7	,	,	PUNCT
admet-376	551	8	j.	j.	PROPN
admet-376	551	9	waddell	waddell	PROPN
admet-376	551	10	,	,	PUNCT
admet-376	551	11	j.l	j.l	PROPN
admet-376	551	12	.	.	PROPN
admet-376	551	13	medina	medina	PROPN
admet-376	551	14	-	-	PUNCT
admet-376	551	15	franco	franco	PROPN
admet-376	551	16	.	.	PUNCT
admet-376	552	1	molecular	molecular	ADJ
admet-376	552	2	scaffold	scaffold	NOUN
admet-376	552	3	analysis	analysis	NOUN
admet-376	552	4	of	of	ADP
admet-376	552	5	natural	natural	ADJ
admet-376	552	6	products	product	NOUN
admet-376	552	7	databases	database	NOUN
admet-376	552	8	in	in	ADP
admet-376	552	9	the	the	DET
admet-376	552	10	public	public	ADJ
admet-376	552	11	domain	domain	NOUN
admet-376	552	12	,	,	PUNCT
admet-376	552	13	chem	chem	NOUN
admet-376	552	14	biol	biol	NOUN
admet-376	552	15	drug	drug	PROPN
admet-376	552	16	des	des	X
admet-376	552	17	80	80	NUM
admet-376	552	18	(	(	PUNCT
admet-376	552	19	2012	2012	NUM
admet-376	552	20	)	)	PUNCT
admet-376	552	21	717	717	NUM
admet-376	552	22	-	-	SYM
admet-376	552	23	724	724	NUM
admet-376	552	24	.	.	PUNCT
admet-376	553	1	[	[	X
admet-376	553	2	121	121	NUM
admet-376	553	3	]	]	X
admet-376	553	4	j.l	j.l	PROPN
admet-376	553	5	.	.	PUNCT
admet-376	553	6	medina	medina	PROPN
admet-376	553	7	-	-	PUNCT
admet-376	553	8	franco	franco	PROPN
admet-376	553	9	,	,	PUNCT
admet-376	553	10	discovery	discovery	NOUN
admet-376	553	11	and	and	CCONJ
admet-376	553	12	development	development	NOUN
admet-376	553	13	of	of	ADP
admet-376	553	14	lead	lead	ADJ
admet-376	553	15	compounds	compound	NOUN
admet-376	553	16	from	from	ADP
admet-376	553	17	natural	natural	ADJ
admet-376	553	18	sources	source	NOUN
admet-376	553	19	using	use	VERB
admet-376	553	20	computational	computational	ADJ
admet-376	553	21	approaches	approach	NOUN
admet-376	553	22	,	,	PUNCT
admet-376	553	23	in	in	ADP
admet-376	553	24	:	:	PUNCT
admet-376	553	25	p.k	p.k	PROPN
admet-376	553	26	.	.	PROPN
admet-376	553	27	mukherjee	mukherjee	PROPN
admet-376	553	28	(	(	PUNCT
admet-376	553	29	ed	ed	NOUN
admet-376	553	30	.	.	PUNCT
admet-376	553	31	)	)	PUNCT
admet-376	553	32	evidence	evidence	NOUN
admet-376	553	33	-	-	PUNCT
admet-376	553	34	based	base	VERB
admet-376	553	35	validation	validation	NOUN
admet-376	553	36	of	of	ADP
admet-376	553	37	herbal	herbal	ADJ
admet-376	553	38	medicine	medicine	NOUN
admet-376	553	39	,	,	PUNCT
admet-376	553	40	elsevier	elsevier	NOUN
admet-376	553	41	,	,	PUNCT
admet-376	553	42	amsterdam	amsterdam	PROPN
admet-376	553	43	,	,	PUNCT
admet-376	553	44	2015	2015	NUM
admet-376	553	45	,	,	PUNCT
admet-376	553	46	pp	pp	ADV
admet-376	553	47	.	.	PUNCT
admet-376	553	48	455	455	NUM
admet-376	553	49	-	-	SYM
admet-376	553	50	475	475	NUM
admet-376	553	51	.	.	PUNCT
admet-376	554	1	[	[	X
admet-376	554	2	122	122	NUM
admet-376	554	3	]	]	X
admet-376	554	4	n.	n.	NOUN
admet-376	554	5	psychogios	psychogios	PROPN
admet-376	554	6	,	,	PUNCT
admet-376	554	7	d.d	d.d	PROPN
admet-376	554	8	.	.	PROPN
admet-376	554	9	hau	hau	PROPN
admet-376	554	10	,	,	PUNCT
admet-376	554	11	j.	j.	PROPN
admet-376	554	12	peng	peng	PROPN
admet-376	554	13	,	,	PUNCT
admet-376	554	14	a.c	a.c	PROPN
admet-376	554	15	.	.	PROPN
admet-376	554	16	guo	guo	PROPN
admet-376	554	17	,	,	PUNCT
admet-376	554	18	r.	r.	PROPN
admet-376	554	19	mandal	mandal	PROPN
admet-376	554	20	,	,	PUNCT
admet-376	554	21	s.	s.	PROPN
admet-376	554	22	bouatra	bouatra	PROPN
admet-376	554	23	,	,	PUNCT
admet-376	554	24	i.	i.	PROPN
admet-376	554	25	sinelnikov	sinelnikov	PROPN
admet-376	554	26	,	,	PUNCT
admet-376	554	27	r.	r.	PROPN
admet-376	554	28	krishnamurthy	krishnamurthy	PROPN
admet-376	554	29	,	,	PUNCT
admet-376	554	30	r.	r.	PROPN
admet-376	554	31	eisner	eisner	PROPN
admet-376	554	32	,	,	PUNCT
admet-376	554	33	b.	b.	PROPN
admet-376	554	34	gautam	gautam	PROPN
admet-376	554	35	,	,	PUNCT
admet-376	554	36	n.	n.	PROPN
admet-376	554	37	young	young	PROPN
admet-376	554	38	,	,	PUNCT
admet-376	554	39	j.	j.	PROPN
admet-376	554	40	xia	xia	PROPN
admet-376	554	41	,	,	PUNCT
admet-376	554	42	c.	c.	PROPN
admet-376	554	43	knox	knox	PROPN
admet-376	554	44	,	,	PUNCT
admet-376	554	45	e.	e.	PROPN
admet-376	554	46	dong	dong	PROPN
admet-376	554	47	,	,	PUNCT
admet-376	554	48	p.	p.	PROPN
admet-376	554	49	huang	huang	PROPN
admet-376	554	50	,	,	PUNCT
admet-376	554	51	z.	z.	PROPN
admet-376	554	52	hollander	hollander	PROPN
admet-376	554	53	,	,	PUNCT
admet-376	554	54	t.l	t.l	PROPN
admet-376	554	55	.	.	PUNCT
admet-376	554	56	pedersen	pedersen	PROPN
admet-376	554	57	,	,	PUNCT
admet-376	554	58	s.r	s.r	PROPN
admet-376	554	59	.	.	PROPN
admet-376	554	60	smith	smith	PROPN
admet-376	554	61	,	,	PUNCT
admet-376	554	62	f.	f.	PROPN
admet-376	554	63	bamforth	bamforth	PROPN
admet-376	554	64	,	,	PUNCT
admet-376	554	65	r.	r.	PROPN
admet-376	554	66	greiner	greiner	PROPN
admet-376	554	67	,	,	PUNCT
admet-376	554	68	b.	b.	PROPN
admet-376	554	69	mcmanus	mcmanus	PROPN
admet-376	554	70	,	,	PUNCT
admet-376	554	71	j.w	j.w	PROPN
admet-376	554	72	.	.	PROPN
admet-376	554	73	newman	newman	PROPN
admet-376	554	74	,	,	PUNCT
admet-376	554	75	t.	t.	PROPN
admet-376	554	76	goodfriend	goodfriend	PROPN
admet-376	554	77	,	,	PUNCT
admet-376	554	78	d.s	d.s	PROPN
admet-376	554	79	.	.	PROPN
admet-376	554	80	wishart	wishart	PROPN
admet-376	554	81	.	.	PUNCT
admet-376	555	1	the	the	DET
admet-376	555	2	human	human	ADJ
admet-376	555	3	serum	serum	PROPN
admet-376	555	4	metabolome	metabolome	PROPN
admet-376	555	5	,	,	PUNCT
admet-376	555	6	plos	plos	PROPN
admet-376	555	7	one	one	NUM
admet-376	555	8	6	6	NUM
admet-376	555	9	(	(	PUNCT
admet-376	555	10	2011	2011	NUM
admet-376	555	11	)	)	PUNCT
admet-376	555	12	e16957	e16957	NOUN
admet-376	555	13	.	.	PUNCT
admet-376	555	14	o'hagan	o'hagan	PROPN
admet-376	555	15	&	&	CCONJ
admet-376	555	16	kell	kell	PROPN
admet-376	555	17	admet	admet	PROPN
admet-376	555	18	&	&	CCONJ
admet-376	555	19	dmpk	dmpk	PROPN
admet-376	555	20	5(2	5(2	NUM
admet-376	555	21	)	)	PUNCT
admet-376	555	22	(	(	PUNCT
admet-376	555	23	2017	2017	NUM
admet-376	555	24	)	)	PUNCT
admet-376	555	25	85	85	NUM
admet-376	555	26	-	-	SYM
admet-376	555	27	125	125	NUM
admet-376	555	28	120	120	NUM
admet-376	555	29	[	[	X
admet-376	555	30	123	123	NUM
admet-376	555	31	]	]	X
admet-376	555	32	j.y	j.y	PROPN
admet-376	555	33	.	.	PROPN
admet-376	555	34	gu	gu	PROPN
admet-376	555	35	,	,	PUNCT
admet-376	555	36	y.s	y.s	PROPN
admet-376	555	37	.	.	PROPN
admet-376	555	38	gui	gui	PROPN
admet-376	555	39	,	,	PUNCT
admet-376	555	40	l.r	l.r	PROPN
admet-376	555	41	.	.	PROPN
admet-376	555	42	chen	chen	PROPN
admet-376	555	43	,	,	PUNCT
admet-376	555	44	g.	g.	PROPN
admet-376	555	45	yuan	yuan	PROPN
admet-376	555	46	,	,	PUNCT
admet-376	555	47	h.z	h.z	PROPN
admet-376	555	48	.	.	PROPN
admet-376	555	49	lu	lu	PROPN
admet-376	555	50	,	,	PUNCT
admet-376	555	51	x.j	x.j	PROPN
admet-376	555	52	.	.	PUNCT
admet-376	555	53	xu	xu	PROPN
admet-376	555	54	.	.	PUNCT
admet-376	556	1	use	use	NOUN
admet-376	556	2	of	of	ADP
admet-376	556	3	natural	natural	ADJ
admet-376	556	4	products	product	NOUN
admet-376	556	5	as	as	ADP
admet-376	556	6	chemical	chemical	NOUN
admet-376	556	7	library	library	NOUN
admet-376	556	8	for	for	ADP
admet-376	556	9	drug	drug	NOUN
admet-376	556	10	discovery	discovery	NOUN
admet-376	556	11	and	and	CCONJ
admet-376	556	12	network	network	NOUN
admet-376	556	13	pharmacology	pharmacology	NOUN
admet-376	556	14	,	,	PUNCT
admet-376	556	15	plos	plos	PROPN
admet-376	556	16	one	one	NUM
admet-376	556	17	8	8	NUM
admet-376	556	18	(	(	PUNCT
admet-376	556	19	2013	2013	NUM
admet-376	556	20	)	)	PUNCT
admet-376	556	21	e62839	e62839	NOUN
admet-376	556	22	.	.	PUNCT
admet-376	557	1	[	[	X
admet-376	557	2	124	124	NUM
admet-376	557	3	]	]	X
admet-376	557	4	j.j	j.j	PROPN
admet-376	557	5	.	.	PROPN
admet-376	557	6	irwin	irwin	PROPN
admet-376	557	7	,	,	PUNCT
admet-376	557	8	t.	t.	PROPN
admet-376	557	9	sterling	sterling	PROPN
admet-376	557	10	,	,	PUNCT
admet-376	557	11	m.m	m.m	PROPN
admet-376	557	12	.	.	PROPN
admet-376	557	13	mysinger	mysinger	PROPN
admet-376	557	14	,	,	PUNCT
admet-376	557	15	e.s	e.s	PROPN
admet-376	557	16	.	.	PROPN
admet-376	557	17	bolstad	bolstad	PROPN
admet-376	557	18	,	,	PUNCT
admet-376	557	19	r.g	r.g	PROPN
admet-376	557	20	.	.	PROPN
admet-376	557	21	coleman	coleman	PROPN
admet-376	557	22	.	.	PUNCT
admet-376	558	1	zinc	zinc	NOUN
admet-376	558	2	:	:	PUNCT
admet-376	558	3	a	a	DET
admet-376	558	4	free	free	ADJ
admet-376	558	5	tool	tool	NOUN
admet-376	558	6	to	to	PART
admet-376	558	7	discover	discover	VERB
admet-376	558	8	chemistry	chemistry	NOUN
admet-376	558	9	for	for	ADP
admet-376	558	10	biology	biology	NOUN
admet-376	558	11	,	,	PUNCT
admet-376	558	12	j	j	PROPN
admet-376	558	13	chem	chem	PROPN
admet-376	558	14	inf	inf	PROPN
admet-376	558	15	model	model	NOUN
admet-376	558	16	52	52	NUM
admet-376	558	17	(	(	PUNCT
admet-376	558	18	2012	2012	NUM
admet-376	558	19	)	)	PUNCT
admet-376	558	20	1757	1757	NUM
admet-376	558	21	-	-	SYM
admet-376	558	22	1768	1768	NUM
admet-376	558	23	.	.	PUNCT
admet-376	559	1	[	[	X
admet-376	559	2	125	125	NUM
admet-376	559	3	]	]	PUNCT
admet-376	559	4	t.	t.	NOUN
admet-376	559	5	sterling	sterling	PROPN
admet-376	559	6	,	,	PUNCT
admet-376	559	7	j.j	j.j	PROPN
admet-376	559	8	.	.	PROPN
admet-376	559	9	irwin	irwin	PROPN
admet-376	559	10	.	.	PUNCT
admet-376	559	11	zinc	zinc	NOUN
admet-376	559	12	15	15	NUM
admet-376	559	13	ligand	ligand	NOUN
admet-376	559	14	discovery	discovery	NOUN
admet-376	559	15	for	for	ADP
admet-376	559	16	everyone	everyone	PRON
admet-376	559	17	,	,	PUNCT
admet-376	559	18	j	j	PROPN
admet-376	559	19	chem	chem	PROPN
admet-376	559	20	inf	inf	PROPN
admet-376	559	21	model	model	NOUN
admet-376	559	22	55	55	NUM
admet-376	559	23	(	(	PUNCT
admet-376	559	24	2015	2015	NUM
admet-376	559	25	)	)	PUNCT
admet-376	559	26	2324	2324	NUM
admet-376	559	27	-	-	SYM
admet-376	559	28	2337	2337	NUM
admet-376	559	29	.	.	PUNCT
admet-376	560	1	[	[	X
admet-376	560	2	126	126	NUM
admet-376	560	3	]	]	X
admet-376	560	4	r.a	r.a	PROPN
admet-376	560	5	.	.	PROPN
admet-376	560	6	hill	hill	PROPN
admet-376	560	7	,	,	PUNCT
admet-376	560	8	dictionary	dictionary	NOUN
admet-376	560	9	of	of	ADP
admet-376	560	10	natural	natural	ADJ
admet-376	560	11	products	product	NOUN
admet-376	560	12	,	,	PUNCT
admet-376	560	13	crc	crc	NOUN
admet-376	560	14	press	press	PROPN
admet-376	560	15	,	,	PUNCT
admet-376	560	16	boca	boca	PROPN
admet-376	560	17	raton	raton	PROPN
admet-376	560	18	,	,	PUNCT
admet-376	560	19	2016	2016	NUM
admet-376	560	20	.	.	PUNCT
admet-376	561	1	[	[	X
admet-376	561	2	127	127	NUM
admet-376	561	3	]	]	X
admet-376	561	4	m.r	m.r	PROPN
admet-376	561	5	.	.	PROPN
admet-376	561	6	berthold	berthold	PROPN
admet-376	561	7	,	,	PUNCT
admet-376	561	8	n.	n.	NOUN
admet-376	561	9	cebron	cebron	PROPN
admet-376	561	10	,	,	PUNCT
admet-376	561	11	f.	f.	PROPN
admet-376	561	12	dill	dill	PROPN
admet-376	561	13	,	,	PUNCT
admet-376	561	14	t.r	t.r	PROPN
admet-376	561	15	.	.	PROPN
admet-376	561	16	gabriel	gabriel	PROPN
admet-376	561	17	,	,	PUNCT
admet-376	561	18	t.	t.	PROPN
admet-376	561	19	kötter	kötter	PROPN
admet-376	561	20	,	,	PUNCT
admet-376	561	21	t.	t.	PROPN
admet-376	561	22	meinl	meinl	NOUN
admet-376	561	23	,	,	PUNCT
admet-376	561	24	p.	p.	NOUN
admet-376	561	25	ohl	ohl	PROPN
admet-376	561	26	,	,	PUNCT
admet-376	561	27	c.	c.	PROPN
admet-376	561	28	sieb	sieb	PROPN
admet-376	561	29	,	,	PUNCT
admet-376	561	30	k.	k.	PROPN
admet-376	561	31	thiel	thiel	PROPN
admet-376	561	32	,	,	PUNCT
admet-376	561	33	b.	b.	PROPN
admet-376	561	34	wiswedel	wiswedel	PROPN
admet-376	561	35	,	,	PUNCT
admet-376	561	36	knime	knime	ADJ
admet-376	561	37	:	:	PUNCT
admet-376	561	38	the	the	DET
admet-376	561	39	konstanz	konstanz	PROPN
admet-376	561	40	information	information	NOUN
admet-376	561	41	miner	miner	NOUN
admet-376	561	42	,	,	PUNCT
admet-376	561	43	in	in	ADP
admet-376	561	44	:	:	PUNCT
admet-376	561	45	c.	c.	PROPN
admet-376	561	46	preisach	preisach	PROPN
admet-376	561	47	,	,	PUNCT
admet-376	561	48	h.	h.	PROPN
admet-376	561	49	burkhardt	burkhardt	PROPN
admet-376	561	50	,	,	PUNCT
admet-376	561	51	l.	l.	PROPN
admet-376	561	52	schmidt	schmidt	PROPN
admet-376	561	53	-	-	PUNCT
admet-376	561	54	thieme	thieme	NOUN
admet-376	561	55	,	,	PUNCT
admet-376	561	56	r.	r.	PROPN
admet-376	561	57	decker	decker	PROPN
admet-376	561	58	(	(	PUNCT
admet-376	561	59	eds	eds	PROPN
admet-376	561	60	.	.	PUNCT
admet-376	561	61	)	)	PUNCT
admet-376	561	62	data	datum	NOUN
admet-376	561	63	analysis	analysis	NOUN
admet-376	561	64	,	,	PUNCT
admet-376	561	65	machine	machine	NOUN
admet-376	561	66	learning	learning	NOUN
admet-376	561	67	and	and	CCONJ
admet-376	561	68	applications	application	NOUN
admet-376	561	69	,	,	PUNCT
admet-376	561	70	springer	springer	NOUN
admet-376	561	71	,	,	PUNCT
admet-376	561	72	berlin	berlin	PROPN
admet-376	561	73	,	,	PUNCT
admet-376	561	74	2008	2008	NUM
admet-376	561	75	,	,	PUNCT
admet-376	561	76	pp	pp	ADJ
admet-376	561	77	.	.	PUNCT
admet-376	562	1	319	319	NUM
admet-376	562	2	-	-	SYM
admet-376	562	3	326	326	NUM
admet-376	562	4	.	.	PUNCT
admet-376	563	1	[	[	X
admet-376	563	2	128	128	NUM
admet-376	563	3	]	]	X
admet-376	563	4	m.p	m.p	PROPN
admet-376	563	5	.	.	PROPN
admet-376	563	6	mazanetz	mazanetz	PROPN
admet-376	563	7	,	,	PUNCT
admet-376	563	8	r.j	r.j	PROPN
admet-376	563	9	.	.	PROPN
admet-376	563	10	marmon	marmon	PROPN
admet-376	563	11	,	,	PUNCT
admet-376	563	12	c.b.t	c.b.t	PROPN
admet-376	563	13	.	.	PUNCT
admet-376	564	1	reisser	reisser	PROPN
admet-376	564	2	,	,	PUNCT
admet-376	564	3	i.	i.	PROPN
admet-376	564	4	morao	morao	PROPN
admet-376	564	5	.	.	PUNCT
admet-376	565	1	drug	drug	NOUN
admet-376	565	2	discovery	discovery	NOUN
admet-376	565	3	applications	application	NOUN
admet-376	565	4	for	for	ADP
admet-376	565	5	knime	knime	NOUN
admet-376	565	6	:	:	PUNCT
admet-376	565	7	an	an	DET
admet-376	565	8	open	open	ADJ
admet-376	565	9	source	source	NOUN
admet-376	565	10	data	data	NOUN
admet-376	565	11	mining	mining	NOUN
admet-376	565	12	platform	platform	NOUN
admet-376	565	13	,	,	PUNCT
admet-376	565	14	curr	curr	PROPN
admet-376	565	15	top	top	ADJ
admet-376	565	16	med	med	ADJ
admet-376	565	17	chem	chem	NOUN
admet-376	565	18	12	12	NUM
admet-376	565	19	(	(	PUNCT
admet-376	565	20	2012	2012	NUM
admet-376	565	21	)	)	PUNCT
admet-376	565	22	1965	1965	NUM
admet-376	565	23	-	-	SYM
admet-376	565	24	1979	1979	NUM
admet-376	565	25	.	.	PUNCT
admet-376	566	1	[	[	X
admet-376	566	2	129	129	NUM
admet-376	566	3	]	]	PUNCT
admet-376	566	4	s.	s.	PROPN
admet-376	566	5	o'hagan	o'hagan	PROPN
admet-376	566	6	,	,	PUNCT
admet-376	566	7	d.b	d.b	PROPN
admet-376	566	8	.	.	PROPN
admet-376	566	9	kell	kell	PROPN
admet-376	566	10	.	.	PUNCT
admet-376	567	1	the	the	DET
admet-376	567	2	knime	knime	ADJ
admet-376	567	3	workflow	workflow	NOUN
admet-376	567	4	environment	environment	NOUN
admet-376	567	5	and	and	CCONJ
admet-376	567	6	its	its	PRON
admet-376	567	7	applications	application	NOUN
admet-376	567	8	in	in	ADP
admet-376	567	9	genetic	genetic	ADJ
admet-376	567	10	programming	programming	NOUN
admet-376	567	11	and	and	CCONJ
admet-376	567	12	machine	machine	NOUN
admet-376	567	13	learning	learning	NOUN
admet-376	567	14	,	,	PUNCT
admet-376	567	15	genetic	genetic	ADJ
admet-376	567	16	progr	progr	NOUN
admet-376	567	17	evol	evol	NOUN
admet-376	567	18	mach	mach	NOUN
admet-376	567	19	16	16	NUM
admet-376	567	20	(	(	PUNCT
admet-376	567	21	2015	2015	NUM
admet-376	567	22	)	)	PUNCT
admet-376	567	23	387	387	NUM
admet-376	567	24	-	-	SYM
admet-376	567	25	391	391	NUM
admet-376	567	26	.	.	PUNCT
admet-376	568	1	[	[	X
admet-376	568	2	130	130	NUM
admet-376	568	3	]	]	X
admet-376	568	4	g.a	g.a	PROPN
admet-376	568	5	.	.	PROPN
admet-376	568	6	landrum	landrum	PROPN
admet-376	568	7	,	,	PUNCT
admet-376	568	8	j.e	j.e	PROPN
admet-376	568	9	.	.	PROPN
admet-376	568	10	penzotti	penzotti	PROPN
admet-376	568	11	,	,	PUNCT
admet-376	568	12	s.	s.	PROPN
admet-376	568	13	putta	putta	PROPN
admet-376	568	14	.	.	PUNCT
admet-376	568	15	feature	feature	NOUN
admet-376	568	16	-	-	PUNCT
admet-376	568	17	map	map	NOUN
admet-376	568	18	vectors	vector	NOUN
admet-376	568	19	:	:	PUNCT
admet-376	568	20	a	a	DET
admet-376	568	21	new	new	ADJ
admet-376	568	22	class	class	NOUN
admet-376	568	23	of	of	ADP
admet-376	568	24	informative	informative	ADJ
admet-376	568	25	descriptors	descriptor	NOUN
admet-376	568	26	for	for	ADP
admet-376	568	27	computational	computational	ADJ
admet-376	568	28	drug	drug	NOUN
admet-376	568	29	discovery	discovery	NOUN
admet-376	568	30	,	,	PUNCT
admet-376	568	31	j	j	PROPN
admet-376	568	32	comput	comput	NOUN
admet-376	568	33	aided	aid	VERB
admet-376	568	34	mol	mol	ADP
admet-376	568	35	des	des	PROPN
admet-376	568	36	20	20	NUM
admet-376	568	37	(	(	PUNCT
admet-376	568	38	2006	2006	NUM
admet-376	568	39	)	)	PUNCT
admet-376	568	40	751	751	NUM
admet-376	568	41	-	-	SYM
admet-376	568	42	762	762	NUM
admet-376	568	43	.	.	PUNCT
admet-376	569	1	[	[	X
admet-376	569	2	131	131	X
admet-376	569	3	]	]	PUNCT
admet-376	569	4	t.	t.	PROPN
admet-376	569	5	kawabata	kawabata	PROPN
admet-376	569	6	.	.	PUNCT
admet-376	570	1	build	build	VERB
admet-376	570	2	-	-	PUNCT
admet-376	570	3	up	up	ADP
admet-376	570	4	algorithm	algorithm	NOUN
admet-376	570	5	for	for	ADP
admet-376	570	6	atomic	atomic	ADJ
admet-376	570	7	correspondence	correspondence	NOUN
admet-376	570	8	between	between	ADP
admet-376	570	9	chemical	chemical	NOUN
admet-376	570	10	structures	structure	NOUN
admet-376	570	11	,	,	PUNCT
admet-376	570	12	j	j	PROPN
admet-376	570	13	chem	chem	PROPN
admet-376	570	14	inf	inf	PROPN
admet-376	570	15	model	model	NOUN
admet-376	570	16	51	51	NUM
admet-376	570	17	(	(	PUNCT
admet-376	570	18	2011	2011	NUM
admet-376	570	19	)	)	PUNCT
admet-376	570	20	1775	1775	NUM
admet-376	570	21	-	-	SYM
admet-376	570	22	1787	1787	NUM
admet-376	570	23	.	.	PUNCT
admet-376	571	1	[	[	X
admet-376	571	2	132	132	NUM
admet-376	571	3	]	]	X
admet-376	571	4	l.	l.	PROPN
admet-376	571	5	breiman	breiman	PROPN
admet-376	571	6	.	.	PUNCT
admet-376	572	1	random	random	ADJ
admet-376	572	2	forests	forest	NOUN
admet-376	572	3	,	,	PUNCT
admet-376	572	4	machine	machine	NOUN
admet-376	572	5	learning	learn	VERB
admet-376	572	6	45	45	NUM
admet-376	572	7	(	(	PUNCT
admet-376	572	8	2001	2001	NUM
admet-376	572	9	)	)	PUNCT
admet-376	572	10	5	5	NUM
admet-376	572	11	-	-	SYM
admet-376	572	12	32	32	NUM
admet-376	572	13	.	.	PUNCT
admet-376	573	1	[	[	X
admet-376	573	2	133	133	NUM
admet-376	573	3	]	]	X
admet-376	573	4	c.g	c.g	PROPN
admet-376	573	5	.	.	PROPN
admet-376	573	6	knight	knight	PROPN
admet-376	573	7	,	,	PUNCT
admet-376	573	8	m.	m.	NOUN
admet-376	573	9	platt	platt	PROPN
admet-376	573	10	,	,	PUNCT
admet-376	573	11	w.	w.	PROPN
admet-376	573	12	rowe	rowe	PROPN
admet-376	573	13	,	,	PUNCT
admet-376	573	14	d.c	d.c	PROPN
admet-376	573	15	.	.	PROPN
admet-376	573	16	wedge	wedge	PROPN
admet-376	573	17	,	,	PUNCT
admet-376	573	18	f.	f.	PROPN
admet-376	573	19	khan	khan	PROPN
admet-376	573	20	,	,	PUNCT
admet-376	573	21	p.	p.	PROPN
admet-376	573	22	day	day	PROPN
admet-376	573	23	,	,	PUNCT
admet-376	573	24	a.	a.	PROPN
admet-376	573	25	mcshea	mcshea	PROPN
admet-376	573	26	,	,	PUNCT
admet-376	573	27	j.	j.	PROPN
admet-376	573	28	knowles	knowles	PROPN
admet-376	573	29	,	,	PUNCT
admet-376	573	30	d.b	d.b	PROPN
admet-376	573	31	.	.	PROPN
admet-376	573	32	kell	kell	PROPN
admet-376	573	33	.	.	PROPN
admet-376	573	34	arraybased	arraybase	VERB
admet-376	573	35	evolution	evolution	NOUN
admet-376	573	36	of	of	ADP
admet-376	573	37	dna	dna	PROPN
admet-376	573	38	aptamers	aptamer	NOUN
admet-376	573	39	allows	allow	VERB
admet-376	573	40	modelling	modelling	NOUN
admet-376	573	41	of	of	ADP
admet-376	573	42	an	an	DET
admet-376	573	43	explicit	explicit	ADJ
admet-376	573	44	sequence	sequence	NOUN
admet-376	573	45	-	-	PUNCT
admet-376	573	46	fitness	fitness	NOUN
admet-376	573	47	landscape	landscape	NOUN
admet-376	573	48	,	,	PUNCT
admet-376	573	49	nucleic	nucleic	ADJ
admet-376	573	50	acids	acid	NOUN
admet-376	573	51	res	re	NOUN
admet-376	573	52	37	37	NUM
admet-376	573	53	(	(	PUNCT
admet-376	573	54	2009	2009	NUM
admet-376	573	55	)	)	PUNCT
admet-376	573	56	e6	e6	NOUN
admet-376	573	57	.	.	PUNCT
admet-376	574	1	[	[	X
admet-376	574	2	134	134	NUM
admet-376	574	3	]	]	X
admet-376	574	4	d.e	d.e	PROPN
admet-376	574	5	.	.	PROPN
admet-376	574	6	ho	ho	PROPN
admet-376	574	7	,	,	PUNCT
admet-376	574	8	k.	k.	PROPN
admet-376	574	9	imai	imai	PROPN
admet-376	574	10	,	,	PUNCT
admet-376	574	11	g.	g.	PROPN
admet-376	574	12	king	king	PROPN
admet-376	574	13	,	,	PUNCT
admet-376	574	14	e.a	e.a	PROPN
admet-376	574	15	.	.	PROPN
admet-376	574	16	stuart	stuart	PROPN
admet-376	574	17	.	.	PUNCT
admet-376	575	1	matching	match	VERB
admet-376	575	2	as	as	ADP
admet-376	575	3	nonparametric	nonparametric	NOUN
admet-376	575	4	preprocessing	preprocessing	NOUN
admet-376	575	5	for	for	ADP
admet-376	575	6	reducing	reduce	VERB
admet-376	575	7	model	model	NOUN
admet-376	575	8	dependence	dependence	NOUN
admet-376	575	9	in	in	ADP
admet-376	575	10	parametric	parametric	ADJ
admet-376	575	11	causal	causal	PROPN
admet-376	575	12	inference	inference	PROPN
admet-376	575	13	,	,	PUNCT
admet-376	575	14	polit	polit	PROPN
admet-376	575	15	anal	anal	ADJ
admet-376	575	16	15	15	NUM
admet-376	575	17	(	(	PUNCT
admet-376	575	18	2007	2007	NUM
admet-376	575	19	)	)	PUNCT
admet-376	575	20	199	199	NUM
admet-376	575	21	-	-	SYM
admet-376	575	22	236	236	NUM
admet-376	575	23	.	.	PUNCT
admet-376	576	1	[	[	X
admet-376	576	2	135	135	NUM
admet-376	576	3	]	]	X
admet-376	576	4	d.e	d.e	PROPN
admet-376	576	5	.	.	PROPN
admet-376	576	6	ho	ho	PROPN
admet-376	576	7	,	,	PUNCT
admet-376	576	8	k.	k.	PROPN
admet-376	576	9	imai	imai	PROPN
admet-376	576	10	,	,	PUNCT
admet-376	576	11	g.	g.	PROPN
admet-376	576	12	king	king	PROPN
admet-376	576	13	,	,	PUNCT
admet-376	576	14	e.a	e.a	PROPN
admet-376	576	15	.	.	PROPN
admet-376	576	16	stuart	stuart	PROPN
admet-376	576	17	.	.	PUNCT
admet-376	577	1	matchit	matchit	PROPN
admet-376	577	2	:	:	PUNCT
admet-376	577	3	nonparametric	nonparametric	NOUN
admet-376	577	4	preprocessing	preprocessing	NOUN
admet-376	577	5	for	for	ADP
admet-376	577	6	parametric	parametric	ADJ
admet-376	577	7	causal	causal	PROPN
admet-376	577	8	inference	inference	NOUN
admet-376	577	9	,	,	PUNCT
admet-376	577	10	j	j	PROPN
admet-376	577	11	stat	stat	PROPN
admet-376	577	12	software	software	PROPN
admet-376	577	13	42	42	NUM
admet-376	577	14	(	(	PUNCT
admet-376	577	15	2011	2011	NUM
admet-376	577	16	)	)	PUNCT
admet-376	577	17	.	.	PUNCT
admet-376	578	1	[	[	X
admet-376	578	2	136	136	NUM
admet-376	578	3	]	]	PUNCT
admet-376	578	4	i.	i.	PROPN
admet-376	578	5	thiele	thiele	PROPN
admet-376	578	6	,	,	PUNCT
admet-376	578	7	n.	n.	PROPN
admet-376	578	8	swainston	swainston	PROPN
admet-376	578	9	,	,	PUNCT
admet-376	578	10	r.m.t	r.m.t	PROPN
admet-376	578	11	.	.	PROPN
admet-376	578	12	fleming	fleming	PROPN
admet-376	578	13	,	,	PUNCT
admet-376	578	14	a.	a.	PROPN
admet-376	578	15	hoppe	hoppe	PROPN
admet-376	578	16	,	,	PUNCT
admet-376	578	17	s.	s.	PROPN
admet-376	578	18	sahoo	sahoo	PROPN
admet-376	578	19	,	,	PUNCT
admet-376	578	20	m.k	m.k	PROPN
admet-376	578	21	.	.	PROPN
admet-376	578	22	aurich	aurich	PROPN
admet-376	578	23	,	,	PUNCT
admet-376	578	24	h.	h.	PROPN
admet-376	578	25	haraldsdottír	haraldsdottír	PROPN
admet-376	578	26	,	,	PUNCT
admet-376	578	27	m.l	m.l	PROPN
admet-376	578	28	.	.	PROPN
admet-376	578	29	mo	mo	PROPN
admet-376	578	30	,	,	PUNCT
admet-376	578	31	o.	o.	PROPN
admet-376	578	32	rolfsson	rolfsson	PROPN
admet-376	578	33	,	,	PUNCT
admet-376	578	34	m.d	m.d	PROPN
admet-376	578	35	.	.	PROPN
admet-376	578	36	stobbe	stobbe	PROPN
admet-376	578	37	,	,	PUNCT
admet-376	578	38	s.g	s.g	PROPN
admet-376	578	39	.	.	PROPN
admet-376	578	40	thorleifsson	thorleifsson	PROPN
admet-376	578	41	,	,	PUNCT
admet-376	578	42	r.	r.	PROPN
admet-376	578	43	agren	agren	PROPN
admet-376	578	44	,	,	PUNCT
admet-376	578	45	c.	c.	PROPN
admet-376	578	46	bölling	bölling	PROPN
admet-376	578	47	,	,	PUNCT
admet-376	578	48	s.	s.	PROPN
admet-376	578	49	bordel	bordel	PROPN
admet-376	578	50	,	,	PUNCT
admet-376	578	51	a.k	a.k	PROPN
admet-376	578	52	.	.	PROPN
admet-376	578	53	chavali	chavali	PROPN
admet-376	578	54	,	,	PUNCT
admet-376	578	55	p.	p.	PROPN
admet-376	578	56	dobson	dobson	PROPN
admet-376	578	57	,	,	PUNCT
admet-376	578	58	w.b	w.b	PROPN
admet-376	578	59	.	.	PROPN
admet-376	578	60	dunn	dunn	PROPN
admet-376	578	61	,	,	PUNCT
admet-376	578	62	l.	l.	PROPN
admet-376	578	63	endler	endler	PROPN
admet-376	578	64	,	,	PUNCT
admet-376	578	65	i.	i.	NOUN
admet-376	578	66	goryanin	goryanin	PROPN
admet-376	578	67	,	,	PUNCT
admet-376	578	68	d.	d.	PROPN
admet-376	578	69	hala	hala	PROPN
admet-376	578	70	,	,	PUNCT
admet-376	578	71	m.	m.	PROPN
admet-376	578	72	hucka	hucka	PROPN
admet-376	578	73	,	,	PUNCT
admet-376	578	74	d.	d.	PROPN
admet-376	578	75	hull	hull	PROPN
admet-376	578	76	,	,	PUNCT
admet-376	578	77	d.	d.	PROPN
admet-376	578	78	jameson	jameson	PROPN
admet-376	578	79	,	,	PUNCT
admet-376	578	80	n.	n.	PROPN
admet-376	578	81	jamshidi	jamshidi	PROPN
admet-376	578	82	,	,	PUNCT
admet-376	578	83	j.	j.	PROPN
admet-376	578	84	jones	jones	PROPN
admet-376	578	85	,	,	PUNCT
admet-376	578	86	j.j	j.j	PROPN
admet-376	578	87	.	.	PROPN
admet-376	578	88	jonsson	jonsson	PROPN
admet-376	578	89	,	,	PUNCT
admet-376	578	90	n.	n.	PROPN
admet-376	578	91	juty	juty	PROPN
admet-376	578	92	,	,	PUNCT
admet-376	578	93	s.	s.	PROPN
admet-376	578	94	keating	keating	PROPN
admet-376	578	95	,	,	PUNCT
admet-376	578	96	i.	i.	PROPN
admet-376	578	97	nookaew	nookaew	PROPN
admet-376	578	98	,	,	PUNCT
admet-376	578	99	n.	n.	PROPN
admet-376	578	100	le	le	PROPN
admet-376	578	101	novère	novère	PROPN
admet-376	578	102	,	,	PUNCT
admet-376	578	103	n.	n.	PROPN
admet-376	578	104	malys	malys	PROPN
admet-376	578	105	,	,	PUNCT
admet-376	578	106	a.	a.	NOUN
admet-376	578	107	mazein	mazein	PROPN
admet-376	578	108	,	,	PUNCT
admet-376	578	109	j.a	j.a	PROPN
admet-376	578	110	.	.	PROPN
admet-376	578	111	papin	papin	PROPN
admet-376	578	112	,	,	PUNCT
admet-376	578	113	y.	y.	PROPN
admet-376	578	114	patel	patel	PROPN
admet-376	578	115	,	,	PUNCT
admet-376	578	116	n.d	n.d	PROPN
admet-376	578	117	.	.	PROPN
admet-376	578	118	price	price	PROPN
admet-376	578	119	,	,	PUNCT
admet-376	578	120	e.	e.	PROPN
admet-376	578	121	selkov	selkov	PROPN
admet-376	578	122	sr	sr	PROPN
admet-376	578	123	.	.	PROPN
admet-376	578	124	,	,	PUNCT
admet-376	578	125	m.i	m.i	PROPN
admet-376	578	126	.	.	PROPN
admet-376	578	127	sigurdsson	sigurdsson	PROPN
admet-376	578	128	,	,	PUNCT
admet-376	578	129	e.	e.	PROPN
admet-376	578	130	simeonidis	simeonidis	PROPN
admet-376	578	131	,	,	PUNCT
admet-376	578	132	n.	n.	PROPN
admet-376	578	133	sonnenschein	sonnenschein	PROPN
admet-376	578	134	,	,	PUNCT
admet-376	578	135	k.	k.	PROPN
admet-376	578	136	smallbone	smallbone	PROPN
admet-376	578	137	,	,	PUNCT
admet-376	578	138	a.	a.	PROPN
admet-376	578	139	sorokin	sorokin	PROPN
admet-376	578	140	,	,	PUNCT
admet-376	578	141	h.v	h.v	PROPN
admet-376	578	142	.	.	PROPN
admet-376	578	143	beek	beek	PROPN
admet-376	578	144	,	,	PUNCT
admet-376	578	145	d.	d.	PROPN
admet-376	578	146	weichart	weichart	PROPN
admet-376	578	147	,	,	PUNCT
admet-376	578	148	j.b	j.b	PROPN
admet-376	578	149	.	.	PROPN
admet-376	578	150	nielsen	nielsen	PROPN
admet-376	578	151	,	,	PUNCT
admet-376	578	152	h.v	h.v	PROPN
admet-376	578	153	.	.	PROPN
admet-376	578	154	westerhoff	westerhoff	PROPN
admet-376	578	155	,	,	PUNCT
admet-376	578	156	d.b	d.b	PROPN
admet-376	578	157	.	.	PROPN
admet-376	578	158	kell	kell	PROPN
admet-376	578	159	,	,	PUNCT
admet-376	578	160	p.	p.	PROPN
admet-376	578	161	mendes	mende	NOUN
admet-376	578	162	,	,	PUNCT
admet-376	578	163	b.ø	b.ø	PROPN
admet-376	578	164	.	.	PROPN
admet-376	578	165	palsson	palsson	PROPN
admet-376	578	166	.	.	PUNCT
admet-376	579	1	a	a	DET
admet-376	579	2	community	community	NOUN
admet-376	579	3	-	-	PUNCT
admet-376	579	4	driven	drive	VERB
admet-376	579	5	global	global	ADJ
admet-376	579	6	reconstruction	reconstruction	NOUN
admet-376	579	7	of	of	ADP
admet-376	579	8	human	human	ADJ
admet-376	579	9	metabolism	metabolism	NOUN
admet-376	579	10	,	,	PUNCT
admet-376	579	11	nat	nat	PROPN
admet-376	579	12	biotechnol	biotechnol	NOUN
admet-376	579	13	.	.	PUNCT
admet-376	580	1	31	31	NUM
admet-376	580	2	(	(	PUNCT
admet-376	580	3	2013	2013	NUM
admet-376	580	4	)	)	PUNCT
admet-376	580	5	419	419	NUM
admet-376	580	6	-	-	SYM
admet-376	580	7	425	425	NUM
admet-376	580	8	.	.	PUNCT
admet-376	581	1	[	[	X
admet-376	581	2	137	137	NUM
admet-376	581	3	]	]	PUNCT
admet-376	581	4	e.	e.	PROPN
admet-376	581	5	fahy	fahy	PROPN
admet-376	581	6	,	,	PUNCT
admet-376	581	7	s.	s.	PROPN
admet-376	581	8	subramaniam	subramaniam	PROPN
admet-376	581	9	,	,	PUNCT
admet-376	581	10	r.c	r.c	PROPN
admet-376	581	11	.	.	PROPN
admet-376	581	12	murphy	murphy	PROPN
admet-376	581	13	,	,	PUNCT
admet-376	581	14	m.	m.	PROPN
admet-376	581	15	nishijima	nishijima	PROPN
admet-376	581	16	,	,	PUNCT
admet-376	581	17	c.r	c.r	PROPN
admet-376	581	18	.	.	PROPN
admet-376	581	19	raetz	raetz	PROPN
admet-376	581	20	,	,	PUNCT
admet-376	581	21	t.	t.	PROPN
admet-376	581	22	shimizu	shimizu	PROPN
admet-376	581	23	,	,	PUNCT
admet-376	581	24	f.	f.	PROPN
admet-376	581	25	spener	spener	PROPN
admet-376	581	26	,	,	PUNCT
admet-376	581	27	g.	g.	PROPN
admet-376	581	28	van	van	PROPN
admet-376	581	29	meer	meer	PROPN
admet-376	581	30	,	,	PUNCT
admet-376	581	31	m.j	m.j	PROPN
admet-376	581	32	.	.	PROPN
admet-376	581	33	wakelam	wakelam	PROPN
admet-376	581	34	,	,	PUNCT
admet-376	581	35	e.a	e.a	PROPN
admet-376	581	36	.	.	PROPN
admet-376	581	37	dennis	dennis	PROPN
admet-376	581	38	.	.	PUNCT
admet-376	582	1	update	update	NOUN
admet-376	582	2	of	of	ADP
admet-376	582	3	the	the	DET
admet-376	582	4	lipid	lipid	NOUN
admet-376	582	5	maps	map	VERB
admet-376	582	6	comprehensive	comprehensive	ADJ
admet-376	582	7	classification	classification	NOUN
admet-376	582	8	system	system	NOUN
admet-376	582	9	for	for	ADP
admet-376	582	10	lipids	lipid	NOUN
admet-376	582	11	,	,	PUNCT
admet-376	582	12	j	j	PROPN
admet-376	582	13	lipid	lipid	NOUN
admet-376	582	14	res	re	VERB
admet-376	582	15	50	50	NUM
admet-376	582	16	suppl	suppl	ADJ
admet-376	582	17	(	(	PUNCT
admet-376	582	18	2009	2009	NUM
admet-376	582	19	)	)	PUNCT
admet-376	582	20	s9	s9	NOUN
admet-376	582	21	-	-	PUNCT
admet-376	582	22	14	14	NUM
admet-376	582	23	.	.	PUNCT
admet-376	583	1	[	[	X
admet-376	583	2	138	138	NUM
admet-376	583	3	]	]	PUNCT
admet-376	583	4	m.	m.	NOUN
admet-376	583	5	whittle	whittle	NOUN
admet-376	583	6	,	,	PUNCT
admet-376	583	7	p.	p.	NOUN
admet-376	583	8	willett	willett	PROPN
admet-376	583	9	,	,	PUNCT
admet-376	583	10	w.	w.	PROPN
admet-376	583	11	klaffke	klaffke	PROPN
admet-376	583	12	,	,	PUNCT
admet-376	583	13	p.	p.	PROPN
admet-376	583	14	van	van	PROPN
admet-376	583	15	noort	noort	NOUN
admet-376	583	16	.	.	PUNCT
admet-376	584	1	evaluation	evaluation	NOUN
admet-376	584	2	of	of	ADP
admet-376	584	3	similarity	similarity	NOUN
admet-376	584	4	measures	measure	NOUN
admet-376	584	5	for	for	ADP
admet-376	584	6	searching	search	VERB
admet-376	584	7	the	the	DET
admet-376	584	8	dictionary	dictionary	NOUN
admet-376	584	9	of	of	ADP
admet-376	584	10	natural	natural	ADJ
admet-376	584	11	products	product	NOUN
admet-376	584	12	database	database	NOUN
admet-376	584	13	,	,	PUNCT
admet-376	584	14	j	j	PROPN
admet-376	584	15	chem	chem	PROPN
admet-376	584	16	inf	inf	PROPN
admet-376	584	17	comput	comput	VERB
admet-376	584	18	sci	sci	PROPN
admet-376	584	19	43	43	NUM
admet-376	584	20	(	(	PUNCT
admet-376	584	21	2003	2003	NUM
admet-376	584	22	)	)	PUNCT
admet-376	584	23	449	449	NUM
admet-376	584	24	-	-	SYM
admet-376	584	25	457	457	NUM
admet-376	584	26	.	.	PUNCT
admet-376	585	1	[	[	X
admet-376	585	2	139	139	NUM
admet-376	585	3	]	]	X
admet-376	585	4	b.n	b.n	PROPN
admet-376	585	5	.	.	PROPN
admet-376	585	6	chen	chen	PROPN
admet-376	585	7	,	,	PUNCT
admet-376	585	8	c.	c.	PROPN
admet-376	585	9	mueller	mueller	PROPN
admet-376	585	10	,	,	PUNCT
admet-376	585	11	p.	p.	PROPN
admet-376	585	12	willett	willett	PROPN
admet-376	585	13	.	.	PUNCT
admet-376	586	1	combination	combination	NOUN
admet-376	586	2	rules	rule	NOUN
admet-376	586	3	for	for	ADP
admet-376	586	4	group	group	NOUN
admet-376	586	5	fusion	fusion	NOUN
admet-376	586	6	in	in	ADP
admet-376	586	7	similarity	similarity	NOUN
admet-376	586	8	-	-	PUNCT
admet-376	586	9	based	base	VERB
admet-376	586	10	virtual	virtual	ADJ
admet-376	586	11	screening	screening	NOUN
admet-376	586	12	,	,	PUNCT
admet-376	586	13	mol	mol	ADP
admet-376	586	14	inform	inform	NOUN
admet-376	586	15	29	29	NUM
admet-376	586	16	(	(	PUNCT
admet-376	586	17	2010	2010	NUM
admet-376	586	18	)	)	PUNCT
admet-376	586	19	533	533	NUM
admet-376	586	20	-	-	SYM
admet-376	586	21	541	541	NUM
admet-376	586	22	.	.	PUNCT
admet-376	587	1	[	[	X
admet-376	587	2	140	140	NUM
admet-376	587	3	]	]	X
admet-376	587	4	e.	e.	PROPN
admet-376	587	5	duesbury	duesbury	PROPN
admet-376	587	6	,	,	PUNCT
admet-376	587	7	j.	j.	PROPN
admet-376	587	8	holliday	holliday	PROPN
admet-376	587	9	,	,	PUNCT
admet-376	587	10	p.	p.	PROPN
admet-376	587	11	willett	willett	PROPN
admet-376	587	12	.	.	PUNCT
admet-376	588	1	maximum	maximum	ADJ
admet-376	588	2	common	common	ADJ
admet-376	588	3	substructure	substructure	NOUN
admet-376	588	4	-	-	PUNCT
admet-376	588	5	based	base	VERB
admet-376	588	6	data	datum	NOUN
admet-376	588	7	fusion	fusion	NOUN
admet-376	588	8	in	in	ADP
admet-376	588	9	similarity	similarity	NOUN
admet-376	588	10	searching	searching	NOUN
admet-376	588	11	,	,	PUNCT
admet-376	588	12	j	j	PROPN
admet-376	588	13	chem	chem	PROPN
admet-376	588	14	inf	inf	PROPN
admet-376	588	15	model	model	NOUN
admet-376	588	16	55	55	NUM
admet-376	588	17	(	(	PUNCT
admet-376	588	18	2015	2015	NUM
admet-376	588	19	)	)	PUNCT
admet-376	588	20	222	222	NUM
admet-376	588	21	-	-	SYM
admet-376	588	22	230	230	NUM
admet-376	588	23	.	.	PUNCT
admet-376	589	1	[	[	X
admet-376	589	2	141	141	NUM
admet-376	589	3	]	]	SYM
admet-376	589	4	c.m.r	c.m.r	NOUN
admet-376	589	5	.	.	PROPN
admet-376	589	6	ginn	ginn	PROPN
admet-376	589	7	,	,	PUNCT
admet-376	589	8	p.	p.	PROPN
admet-376	589	9	willett	willett	PROPN
admet-376	589	10	,	,	PUNCT
admet-376	589	11	j.	j.	PROPN
admet-376	589	12	bradshaw	bradshaw	PROPN
admet-376	589	13	.	.	PUNCT
admet-376	590	1	combination	combination	NOUN
admet-376	590	2	of	of	ADP
admet-376	590	3	molecular	molecular	ADJ
admet-376	590	4	similarity	similarity	NOUN
admet-376	590	5	measures	measure	NOUN
admet-376	590	6	using	use	VERB
admet-376	590	7	data	datum	NOUN
admet-376	590	8	fusion	fusion	NOUN
admet-376	590	9	,	,	PUNCT
admet-376	590	10	perspect	perspect	ADJ
admet-376	590	11	drug	drug	NOUN
admet-376	590	12	discov	discov	NOUN
admet-376	590	13	20	20	NUM
admet-376	590	14	(	(	PUNCT
admet-376	590	15	2000	2000	NUM
admet-376	590	16	)	)	PUNCT
admet-376	590	17	1	1	NUM
admet-376	590	18	-	-	SYM
admet-376	590	19	16	16	NUM
admet-376	590	20	.	.	PUNCT
admet-376	591	1	[	[	X
admet-376	591	2	142	142	NUM
admet-376	591	3	]	]	PUNCT
admet-376	591	4	n.	n.	PROPN
admet-376	591	5	salim	salim	PROPN
admet-376	591	6	,	,	PUNCT
admet-376	591	7	j.	j.	PROPN
admet-376	591	8	holliday	holliday	PROPN
admet-376	591	9	,	,	PUNCT
admet-376	591	10	p.	p.	PROPN
admet-376	591	11	willett	willett	PROPN
admet-376	591	12	.	.	PUNCT
admet-376	591	13	combination	combination	NOUN
admet-376	591	14	of	of	ADP
admet-376	591	15	fingerprint	fingerprint	NOUN
admet-376	591	16	-	-	PUNCT
admet-376	591	17	based	base	VERB
admet-376	591	18	similarity	similarity	NOUN
admet-376	591	19	coefficients	coefficient	NOUN
admet-376	591	20	using	use	VERB
admet-376	591	21	data	datum	NOUN
admet-376	591	22	fusion	fusion	NOUN
admet-376	591	23	,	,	PUNCT
admet-376	591	24	j	j	PROPN
admet-376	591	25	chem	chem	PROPN
admet-376	591	26	inf	inf	PROPN
admet-376	591	27	comp	comp	NOUN
admet-376	591	28	sci	sci	PROPN
admet-376	591	29	43	43	NUM
admet-376	591	30	(	(	PUNCT
admet-376	591	31	2003	2003	NUM
admet-376	591	32	)	)	PUNCT
admet-376	591	33	435	435	NUM
admet-376	591	34	-	-	SYM
admet-376	591	35	442	442	NUM
admet-376	591	36	.	.	PUNCT
admet-376	592	1	[	[	X
admet-376	592	2	143	143	NUM
admet-376	592	3	]	]	X
admet-376	592	4	m.	m.	NOUN
admet-376	592	5	whittle	whittle	NOUN
admet-376	592	6	,	,	PUNCT
admet-376	592	7	v.j	v.j	PROPN
admet-376	592	8	.	.	PROPN
admet-376	592	9	gillet	gillet	PROPN
admet-376	592	10	,	,	PUNCT
admet-376	592	11	p.	p.	NOUN
admet-376	592	12	willett	willett	PROPN
admet-376	592	13	,	,	PUNCT
admet-376	592	14	j.	j.	PROPN
admet-376	592	15	loesel	loesel	PROPN
admet-376	592	16	.	.	PUNCT
admet-376	593	1	analysis	analysis	NOUN
admet-376	593	2	of	of	ADP
admet-376	593	3	data	datum	NOUN
admet-376	593	4	fusion	fusion	NOUN
admet-376	593	5	methods	method	NOUN
admet-376	593	6	in	in	ADP
admet-376	593	7	virtual	virtual	ADJ
admet-376	593	8	screening	screening	NOUN
admet-376	593	9	:	:	PUNCT
admet-376	593	10	theoretical	theoretical	ADJ
admet-376	593	11	model	model	NOUN
admet-376	593	12	,	,	PUNCT
admet-376	593	13	j	j	PROPN
admet-376	593	14	chem	chem	PROPN
admet-376	593	15	inf	inf	PROPN
admet-376	593	16	model	model	NOUN
admet-376	593	17	46	46	NUM
admet-376	593	18	(	(	PUNCT
admet-376	593	19	2006	2006	NUM
admet-376	593	20	)	)	PUNCT
admet-376	593	21	2193	2193	NUM
admet-376	593	22	-	-	SYM
admet-376	593	23	2205	2205	NUM
admet-376	593	24	.	.	PUNCT
admet-376	594	1	[	[	X
admet-376	594	2	144	144	NUM
admet-376	594	3	]	]	X
admet-376	594	4	p.	p.	NOUN
admet-376	594	5	willett	willett	PROPN
admet-376	594	6	.	.	PUNCT
admet-376	595	1	combination	combination	NOUN
admet-376	595	2	of	of	ADP
admet-376	595	3	similarity	similarity	NOUN
admet-376	595	4	rankings	ranking	NOUN
admet-376	595	5	using	use	VERB
admet-376	595	6	data	datum	NOUN
admet-376	595	7	fusion	fusion	NOUN
admet-376	595	8	,	,	PUNCT
admet-376	595	9	j	j	PROPN
admet-376	595	10	chem	chem	PROPN
admet-376	595	11	inf	inf	PROPN
admet-376	595	12	model	model	NOUN
admet-376	595	13	53	53	NUM
admet-376	595	14	(	(	PUNCT
admet-376	595	15	2013	2013	NUM
admet-376	595	16	)	)	PUNCT
admet-376	595	17	1	1	NUM
admet-376	595	18	-	-	SYM
admet-376	595	19	10	10	NUM
admet-376	595	20	.	.	PUNCT
admet-376	596	1	admet	admet	PROPN
admet-376	596	2	&	&	CCONJ
admet-376	596	3	dmpk	dmpk	PROPN
admet-376	596	4	5(2	5(2	NUM
admet-376	596	5	)	)	PUNCT
admet-376	596	6	(	(	PUNCT
admet-376	596	7	2017	2017	NUM
admet-376	596	8	)	)	PUNCT
admet-376	596	9	85	85	NUM
admet-376	596	10	-	-	SYM
admet-376	596	11	125	125	NUM
admet-376	596	12	exogenous	exogenous	ADJ
admet-376	596	13	natural	natural	ADJ
admet-376	596	14	products	product	NOUN
admet-376	596	15	as	as	ADP
admet-376	596	16	‘	'	PUNCT
admet-376	596	17	natural	natural	ADJ
admet-376	596	18	’	'	PUNCT
admet-376	596	19	drug	drug	NOUN
admet-376	596	20	transporter	transporter	NOUN
admet-376	596	21	substrates	substrate	VERB
admet-376	596	22	doi	doi	NOUN
admet-376	596	23	:	:	PUNCT
admet-376	596	24	10.5599	10.5599	NUM
admet-376	596	25	/	/	SYM
admet-376	596	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	596	27	121	121	NUM
admet-376	596	28	[	[	X
admet-376	596	29	145	145	NUM
admet-376	596	30	]	]	SYM
admet-376	596	31	v.j	v.j	PROPN
admet-376	596	32	.	.	PROPN
admet-376	596	33	gillet	gillet	PROPN
admet-376	596	34	,	,	PUNCT
admet-376	596	35	j.d	j.d	PROPN
admet-376	596	36	.	.	PROPN
admet-376	596	37	holliday	holliday	PROPN
admet-376	596	38	,	,	PUNCT
admet-376	596	39	p.	p.	PROPN
admet-376	596	40	willett	willett	PROPN
admet-376	596	41	.	.	PUNCT
admet-376	597	1	chemoinformatics	chemoinformatic	NOUN
admet-376	597	2	at	at	ADP
admet-376	597	3	the	the	DET
admet-376	597	4	university	university	PROPN
admet-376	597	5	of	of	ADP
admet-376	597	6	sheffield	sheffield	PROPN
admet-376	597	7	2002	2002	NUM
admet-376	597	8	-	-	SYM
admet-376	597	9	2014	2014	NUM
admet-376	597	10	,	,	PUNCT
admet-376	597	11	mol	mol	ADP
admet-376	597	12	inform	inform	NOUN
admet-376	597	13	34	34	NUM
admet-376	597	14	(	(	PUNCT
admet-376	597	15	2015	2015	NUM
admet-376	597	16	)	)	PUNCT
admet-376	597	17	598	598	NUM
admet-376	597	18	-	-	SYM
admet-376	597	19	607	607	NUM
admet-376	597	20	.	.	PUNCT
admet-376	598	1	[	[	X
admet-376	598	2	146	146	NUM
admet-376	598	3	]	]	X
admet-376	598	4	h.c	h.c	PROPN
admet-376	598	5	.	.	PUNCT
admet-376	598	6	liu	liu	PROPN
admet-376	598	7	,	,	PUNCT
admet-376	598	8	n.	n.	PROPN
admet-376	598	9	jamshidi	jamshidi	PROPN
admet-376	598	10	,	,	PUNCT
admet-376	598	11	y.	y.	PROPN
admet-376	598	12	chen	chen	PROPN
admet-376	598	13	,	,	PUNCT
admet-376	598	14	s.a	s.a	PROPN
admet-376	598	15	.	.	PROPN
admet-376	598	16	eraly	eraly	PROPN
admet-376	598	17	,	,	PUNCT
admet-376	598	18	s.y	s.y	PROPN
admet-376	598	19	.	.	PROPN
admet-376	598	20	cho	cho	PROPN
admet-376	598	21	,	,	PUNCT
admet-376	598	22	v.	v.	PROPN
admet-376	598	23	bhatnagar	bhatnagar	PROPN
admet-376	598	24	,	,	PUNCT
admet-376	598	25	w.	w.	PROPN
admet-376	598	26	wu	wu	PROPN
admet-376	598	27	,	,	PUNCT
admet-376	598	28	k.t	k.t	PROPN
admet-376	598	29	.	.	PROPN
admet-376	598	30	bush	bush	PROPN
admet-376	598	31	,	,	PUNCT
admet-376	598	32	r.	r.	PROPN
admet-376	598	33	abagyan	abagyan	PROPN
admet-376	598	34	,	,	PUNCT
admet-376	598	35	b.o	b.o	PROPN
admet-376	598	36	.	.	PROPN
admet-376	598	37	palsson	palsson	PROPN
admet-376	598	38	,	,	PUNCT
admet-376	598	39	s.k	s.k	PROPN
admet-376	598	40	.	.	PROPN
admet-376	598	41	nigam	nigam	PROPN
admet-376	598	42	.	.	PUNCT
admet-376	599	1	an	an	DET
admet-376	599	2	organic	organic	ADJ
admet-376	599	3	anion	anion	NOUN
admet-376	599	4	transporter	transporter	NOUN
admet-376	599	5	1	1	NUM
admet-376	599	6	(	(	PUNCT
admet-376	599	7	oat1)-centered	oat1)-centere	VERB
admet-376	599	8	metabolic	metabolic	NOUN
admet-376	599	9	network	network	NOUN
admet-376	599	10	,	,	PUNCT
admet-376	599	11	j	j	PROPN
admet-376	599	12	biol	biol	PROPN
admet-376	599	13	chem	chem	NOUN
admet-376	599	14	291	291	NUM
admet-376	599	15	(	(	PUNCT
admet-376	599	16	2016	2016	NUM
admet-376	599	17	)	)	PUNCT
admet-376	599	18	19474	19474	NUM
admet-376	599	19	-	-	SYM
admet-376	599	20	19486	19486	NUM
admet-376	599	21	.	.	PUNCT
admet-376	600	1	[	[	X
admet-376	600	2	147	147	NUM
admet-376	600	3	]	]	X
admet-376	600	4	f.	f.	PROPN
admet-376	600	5	samsudin	samsudin	PROPN
admet-376	600	6	,	,	PUNCT
admet-376	600	7	j.l	j.l	PROPN
admet-376	600	8	.	.	PROPN
admet-376	600	9	parker	parker	PROPN
admet-376	600	10	,	,	PUNCT
admet-376	600	11	m.s.p	m.s.p	PROPN
admet-376	600	12	.	.	PUNCT
admet-376	601	1	sansom	sansom	PROPN
admet-376	601	2	,	,	PUNCT
admet-376	601	3	s.	s.	PROPN
admet-376	601	4	newstead	newstead	PROPN
admet-376	601	5	,	,	PUNCT
admet-376	601	6	p.w	p.w	PROPN
admet-376	601	7	.	.	PROPN
admet-376	601	8	fowler	fowler	PROPN
admet-376	601	9	.	.	PUNCT
admet-376	602	1	accurate	accurate	ADJ
admet-376	602	2	prediction	prediction	NOUN
admet-376	602	3	of	of	ADP
admet-376	602	4	ligand	ligand	ADJ
admet-376	602	5	affinities	affinity	NOUN
admet-376	602	6	for	for	ADP
admet-376	602	7	a	a	DET
admet-376	602	8	proton	proton	NOUN
admet-376	602	9	-	-	PUNCT
admet-376	602	10	dependent	dependent	ADJ
admet-376	602	11	oligopeptide	oligopeptide	NOUN
admet-376	602	12	transporter	transporter	NOUN
admet-376	602	13	,	,	PUNCT
admet-376	602	14	cell	cell	NOUN
admet-376	602	15	chem	chem	NOUN
admet-376	602	16	biol	biol	NOUN
admet-376	602	17	23	23	NUM
admet-376	602	18	(	(	PUNCT
admet-376	602	19	2016	2016	NUM
admet-376	602	20	)	)	PUNCT
admet-376	602	21	299	299	NUM
admet-376	602	22	-	-	SYM
admet-376	602	23	309	309	NUM
admet-376	602	24	.	.	PUNCT
admet-376	603	1	[	[	X
admet-376	603	2	148	148	NUM
admet-376	603	3	]	]	X
admet-376	603	4	c.a	c.a	PROPN
admet-376	603	5	.	.	PROPN
admet-376	603	6	lipinski	lipinski	PROPN
admet-376	603	7	,	,	PUNCT
admet-376	603	8	f.	f.	PROPN
admet-376	603	9	lombardo	lombardo	PROPN
admet-376	603	10	,	,	PUNCT
admet-376	603	11	b.w	b.w	PROPN
admet-376	603	12	.	.	PROPN
admet-376	603	13	dominy	dominy	PROPN
admet-376	603	14	,	,	PUNCT
admet-376	603	15	p.j	p.j	PROPN
admet-376	603	16	.	.	PROPN
admet-376	603	17	feeney	feeney	PROPN
admet-376	603	18	.	.	PUNCT
admet-376	604	1	experimental	experimental	ADJ
admet-376	604	2	and	and	CCONJ
admet-376	604	3	computational	computational	ADJ
admet-376	604	4	approaches	approach	NOUN
admet-376	604	5	to	to	PART
admet-376	604	6	estimate	estimate	VERB
admet-376	604	7	solubility	solubility	NOUN
admet-376	604	8	and	and	CCONJ
admet-376	604	9	permeability	permeability	NOUN
admet-376	604	10	in	in	ADP
admet-376	604	11	drug	drug	NOUN
admet-376	604	12	discovery	discovery	NOUN
admet-376	604	13	and	and	CCONJ
admet-376	604	14	development	development	NOUN
admet-376	604	15	settings	setting	NOUN
admet-376	604	16	,	,	PUNCT
admet-376	604	17	adv	adv	PROPN
admet-376	604	18	drug	drug	NOUN
admet-376	604	19	deliv	deliv	NOUN
admet-376	604	20	rev	rev	VERB
admet-376	604	21	23	23	NUM
admet-376	604	22	(	(	PUNCT
admet-376	604	23	1997	1997	NUM
admet-376	604	24	)	)	PUNCT
admet-376	604	25	3	3	NUM
admet-376	604	26	-	-	SYM
admet-376	604	27	25	25	NUM
admet-376	604	28	.	.	PUNCT
admet-376	605	1	[	[	X
admet-376	605	2	149	149	NUM
admet-376	605	3	]	]	PUNCT
admet-376	605	4	j.	j.	PROPN
admet-376	605	5	clardy	clardy	PROPN
admet-376	605	6	,	,	PUNCT
admet-376	605	7	c.	c.	PROPN
admet-376	605	8	walsh	walsh	PROPN
admet-376	605	9	.	.	PUNCT
admet-376	606	1	lessons	lesson	NOUN
admet-376	606	2	from	from	ADP
admet-376	606	3	natural	natural	ADJ
admet-376	606	4	molecules	molecule	NOUN
admet-376	606	5	,	,	PUNCT
admet-376	606	6	nature	nature	NOUN
admet-376	606	7	432	432	NUM
admet-376	606	8	(	(	PUNCT
admet-376	606	9	2004	2004	NUM
admet-376	606	10	)	)	PUNCT
admet-376	606	11	829	829	NUM
admet-376	606	12	-	-	SYM
admet-376	606	13	837	837	NUM
admet-376	606	14	.	.	PUNCT
admet-376	607	1	[	[	X
admet-376	607	2	150	150	NUM
admet-376	607	3	]	]	PUNCT
admet-376	607	4	c.	c.	PROPN
admet-376	607	5	abad	abad	PROPN
admet-376	607	6	-	-	PUNCT
admet-376	607	7	zapatero	zapatero	PROPN
admet-376	607	8	.	.	PUNCT
admet-376	608	1	a	a	DET
admet-376	608	2	sorcerer	sorcerer	NOUN
admet-376	608	3	's	's	PART
admet-376	608	4	apprentice	apprentice	NOUN
admet-376	608	5	and	and	CCONJ
admet-376	608	6	the	the	DET
admet-376	608	7	rule	rule	NOUN
admet-376	608	8	of	of	ADP
admet-376	608	9	five	five	NUM
admet-376	608	10	:	:	PUNCT
admet-376	608	11	from	from	ADP
admet-376	608	12	rule	rule	NOUN
admet-376	608	13	-	-	PUNCT
admet-376	608	14	of	of	ADP
admet-376	608	15	-	-	PUNCT
admet-376	608	16	thumb	thumb	NOUN
admet-376	608	17	to	to	PART
admet-376	608	18	commandment	commandment	VERB
admet-376	608	19	and	and	CCONJ
admet-376	608	20	beyond	beyond	ADP
admet-376	608	21	,	,	PUNCT
admet-376	608	22	drug	drug	NOUN
admet-376	608	23	discov	discov	NOUN
admet-376	608	24	today	today	NOUN
admet-376	608	25	12	12	NUM
admet-376	608	26	(	(	PUNCT
admet-376	608	27	2007	2007	NUM
admet-376	608	28	)	)	PUNCT
admet-376	608	29	995	995	NUM
admet-376	608	30	-	-	SYM
admet-376	608	31	997	997	NUM
admet-376	608	32	.	.	PUNCT
admet-376	609	1	[	[	X
admet-376	609	2	151	151	NUM
admet-376	609	3	]	]	SYM
admet-376	609	4	s.b	s.b	PROPN
admet-376	609	5	.	.	PROPN
admet-376	609	6	singh	singh	PROPN
admet-376	609	7	,	,	PUNCT
admet-376	609	8	f.	f.	PROPN
admet-376	609	9	pelaez	pelaez	PROPN
admet-376	609	10	.	.	PUNCT
admet-376	610	1	biodiversity	biodiversity	NOUN
admet-376	610	2	,	,	PUNCT
admet-376	610	3	chemical	chemical	NOUN
admet-376	610	4	diversity	diversity	NOUN
admet-376	610	5	and	and	CCONJ
admet-376	610	6	drug	drug	NOUN
admet-376	610	7	discovery	discovery	NOUN
admet-376	610	8	,	,	PUNCT
admet-376	610	9	prog	prog	NOUN
admet-376	610	10	drug	drug	NOUN
admet-376	610	11	res	re	NOUN
admet-376	610	12	65	65	NUM
admet-376	610	13	(	(	PUNCT
admet-376	610	14	2008	2008	NUM
admet-376	610	15	)	)	PUNCT
admet-376	610	16	141	141	NUM
admet-376	610	17	,	,	PUNCT
admet-376	610	18	143	143	NUM
admet-376	610	19	-	-	SYM
admet-376	610	20	174	174	NUM
admet-376	610	21	.	.	PUNCT
admet-376	611	1	[	[	X
admet-376	611	2	152	152	NUM
admet-376	611	3	]	]	X
admet-376	611	4	b.c	b.c	PROPN
admet-376	611	5	.	.	PROPN
admet-376	611	6	doak	doak	PROPN
admet-376	611	7	,	,	PUNCT
admet-376	611	8	b.	b.	PROPN
admet-376	611	9	over	over	PROPN
admet-376	611	10	,	,	PUNCT
admet-376	611	11	f.	f.	PROPN
admet-376	611	12	giordanetto	giordanetto	PROPN
admet-376	611	13	,	,	PUNCT
admet-376	611	14	j.	j.	PROPN
admet-376	611	15	kihlberg	kihlberg	PROPN
admet-376	611	16	.	.	PUNCT
admet-376	612	1	oral	oral	ADJ
admet-376	612	2	druggable	druggable	ADJ
admet-376	612	3	space	space	NOUN
admet-376	612	4	beyond	beyond	ADP
admet-376	612	5	the	the	DET
admet-376	612	6	rule	rule	NOUN
admet-376	612	7	of	of	ADP
admet-376	612	8	5	5	NUM
admet-376	612	9	:	:	PUNCT
admet-376	612	10	insights	insight	NOUN
admet-376	612	11	from	from	ADP
admet-376	612	12	drugs	drug	NOUN
admet-376	612	13	and	and	CCONJ
admet-376	612	14	clinical	clinical	ADJ
admet-376	612	15	candidates	candidate	NOUN
admet-376	612	16	,	,	PUNCT
admet-376	612	17	chem	chem	NOUN
admet-376	612	18	biol	biol	NOUN
admet-376	612	19	21	21	NUM
admet-376	612	20	(	(	PUNCT
admet-376	612	21	2014	2014	NUM
admet-376	612	22	)	)	PUNCT
admet-376	612	23	1115	1115	NUM
admet-376	612	24	-	-	SYM
admet-376	612	25	1142	1142	NUM
admet-376	612	26	.	.	PUNCT
admet-376	613	1	[	[	X
admet-376	613	2	153	153	NUM
admet-376	613	3	]	]	PUNCT
admet-376	613	4	j.	j.	PROPN
admet-376	613	5	petit	petit	PROPN
admet-376	613	6	,	,	PUNCT
admet-376	613	7	n.	n.	PROPN
admet-376	613	8	meurice	meurice	PROPN
admet-376	613	9	,	,	PUNCT
admet-376	613	10	c.	c.	PROPN
admet-376	613	11	kaiser	kaiser	PROPN
admet-376	613	12	,	,	PUNCT
admet-376	613	13	g.	g.	PROPN
admet-376	613	14	maggiora	maggiora	PROPN
admet-376	613	15	.	.	PUNCT
admet-376	614	1	softening	soften	VERB
admet-376	614	2	the	the	DET
admet-376	614	3	rule	rule	NOUN
admet-376	614	4	of	of	ADP
admet-376	614	5	five	five	NUM
admet-376	614	6	-	-	PUNCT
admet-376	614	7	where	where	SCONJ
admet-376	614	8	to	to	PART
admet-376	614	9	draw	draw	VERB
admet-376	614	10	the	the	DET
admet-376	614	11	line	line	NOUN
admet-376	614	12	?	?	PUNCT
admet-376	614	13	,	,	PUNCT
admet-376	614	14	bioorg	bioorg	PROPN
admet-376	614	15	med	med	ADJ
admet-376	614	16	chem	chem	NOUN
admet-376	614	17	20	20	NUM
admet-376	614	18	(	(	PUNCT
admet-376	614	19	2012	2012	NUM
admet-376	614	20	)	)	PUNCT
admet-376	614	21	5343	5343	NUM
admet-376	614	22	-	-	PUNCT
admet-376	614	23	5351	5351	NUM
admet-376	614	24	.	.	PUNCT
admet-376	615	1	[	[	X
admet-376	615	2	154	154	NUM
admet-376	615	3	]	]	X
admet-376	615	4	p.d	p.d	PROPN
admet-376	615	5	.	.	PROPN
admet-376	615	6	leeson	leeson	PROPN
admet-376	615	7	.	.	PUNCT
admet-376	616	1	molecular	molecular	ADJ
admet-376	616	2	inflation	inflation	NOUN
admet-376	616	3	,	,	PUNCT
admet-376	616	4	attrition	attrition	NOUN
admet-376	616	5	and	and	CCONJ
admet-376	616	6	the	the	DET
admet-376	616	7	rule	rule	NOUN
admet-376	616	8	of	of	ADP
admet-376	616	9	five	five	NUM
admet-376	616	10	,	,	PUNCT
admet-376	616	11	adv	adv	PROPN
admet-376	616	12	drug	drug	NOUN
admet-376	616	13	deliv	deliv	NOUN
admet-376	616	14	rev	rev	VERB
admet-376	616	15	101	101	NUM
admet-376	616	16	(	(	PUNCT
admet-376	616	17	2016	2016	NUM
admet-376	616	18	)	)	PUNCT
admet-376	616	19	22	22	NUM
admet-376	616	20	-	-	SYM
admet-376	616	21	33	33	NUM
admet-376	616	22	.	.	PUNCT
admet-376	617	1	[	[	X
admet-376	617	2	155	155	NUM
admet-376	617	3	]	]	X
admet-376	617	4	r.	r.	NOUN
admet-376	617	5	gozalbes	gozalbe	NOUN
admet-376	617	6	,	,	PUNCT
admet-376	617	7	a.	a.	PROPN
admet-376	617	8	pineda	pineda	PROPN
admet-376	617	9	-	-	PUNCT
admet-376	617	10	lucena	lucena	PROPN
admet-376	617	11	.	.	PUNCT
admet-376	618	1	small	small	ADJ
admet-376	618	2	molecule	molecule	NOUN
admet-376	618	3	databases	database	NOUN
admet-376	618	4	and	and	CCONJ
admet-376	618	5	chemical	chemical	NOUN
admet-376	618	6	descriptors	descriptor	NOUN
admet-376	618	7	useful	useful	ADJ
admet-376	618	8	in	in	ADP
admet-376	618	9	chemoinformatics	chemoinformatic	NOUN
admet-376	618	10	:	:	PUNCT
admet-376	618	11	an	an	DET
admet-376	618	12	overview	overview	NOUN
admet-376	618	13	,	,	PUNCT
admet-376	618	14	comb	comb	VERB
admet-376	618	15	chem	chem	NOUN
admet-376	618	16	high	high	ADJ
admet-376	618	17	throughput	throughput	NOUN
admet-376	618	18	screen	screen	NOUN
admet-376	618	19	14	14	NUM
admet-376	618	20	(	(	PUNCT
admet-376	618	21	2011	2011	NUM
admet-376	618	22	)	)	PUNCT
admet-376	618	23	548	548	NUM
admet-376	618	24	-	-	SYM
admet-376	618	25	558	558	NUM
admet-376	618	26	.	.	PUNCT
admet-376	619	1	[	[	X
admet-376	619	2	156	156	NUM
admet-376	619	3	]	]	X
admet-376	619	4	g.a	g.a	PROPN
admet-376	619	5	.	.	PROPN
admet-376	619	6	holdgate	holdgate	PROPN
admet-376	619	7	.	.	PUNCT
admet-376	620	1	thermodynamics	thermodynamic	NOUN
admet-376	620	2	of	of	ADP
admet-376	620	3	binding	bind	VERB
admet-376	620	4	interactions	interaction	NOUN
admet-376	620	5	in	in	ADP
admet-376	620	6	the	the	DET
admet-376	620	7	rational	rational	ADJ
admet-376	620	8	drug	drug	NOUN
admet-376	620	9	design	design	NOUN
admet-376	620	10	process	process	NOUN
admet-376	620	11	,	,	PUNCT
admet-376	620	12	expert	expert	ADJ
admet-376	620	13	opinion	opinion	NOUN
admet-376	620	14	on	on	ADP
admet-376	620	15	drug	drug	NOUN
admet-376	620	16	discovery	discovery	NOUN
admet-376	620	17	2	2	NUM
admet-376	620	18	(	(	PUNCT
admet-376	620	19	2007	2007	NUM
admet-376	620	20	)	)	PUNCT
admet-376	620	21	1103	1103	NUM
admet-376	620	22	-	-	SYM
admet-376	620	23	1114	1114	NUM
admet-376	620	24	.	.	PUNCT
admet-376	621	1	[	[	X
admet-376	621	2	157	157	NUM
admet-376	621	3	]	]	X
admet-376	621	4	d.j	d.j	PROPN
admet-376	621	5	.	.	PROPN
admet-376	621	6	newman	newman	PROPN
admet-376	621	7	,	,	PUNCT
admet-376	621	8	g.m	g.m	PROPN
admet-376	621	9	.	.	PROPN
admet-376	621	10	cragg	cragg	PROPN
admet-376	621	11	.	.	PUNCT
admet-376	622	1	natural	natural	ADJ
admet-376	622	2	products	product	NOUN
admet-376	622	3	as	as	ADP
admet-376	622	4	sources	source	NOUN
admet-376	622	5	of	of	ADP
admet-376	622	6	new	new	ADJ
admet-376	622	7	drugs	drug	NOUN
admet-376	622	8	over	over	ADP
admet-376	622	9	the	the	DET
admet-376	622	10	30	30	NUM
admet-376	622	11	years	year	NOUN
admet-376	622	12	from	from	ADP
admet-376	622	13	1981	1981	NUM
admet-376	622	14	to	to	ADP
admet-376	622	15	2010	2010	NUM
admet-376	622	16	,	,	PUNCT
admet-376	622	17	j	j	PROPN
admet-376	622	18	nat	nat	PROPN
admet-376	622	19	prod	prod	VERB
admet-376	622	20	75	75	NUM
admet-376	622	21	(	(	PUNCT
admet-376	622	22	2012	2012	NUM
admet-376	622	23	)	)	PUNCT
admet-376	622	24	311	311	NUM
admet-376	622	25	-	-	SYM
admet-376	622	26	335	335	NUM
admet-376	622	27	.	.	PUNCT
admet-376	623	1	[	[	X
admet-376	623	2	158	158	NUM
admet-376	623	3	]	]	X
admet-376	623	4	d.j	d.j	PROPN
admet-376	623	5	.	.	PROPN
admet-376	623	6	newman	newman	PROPN
admet-376	623	7	,	,	PUNCT
admet-376	623	8	g.m	g.m	PROPN
admet-376	623	9	.	.	PROPN
admet-376	623	10	cragg	cragg	PROPN
admet-376	623	11	.	.	PUNCT
admet-376	623	12	natural	natural	ADJ
admet-376	623	13	products	product	NOUN
admet-376	623	14	as	as	ADP
admet-376	623	15	sources	source	NOUN
admet-376	623	16	of	of	ADP
admet-376	623	17	new	new	ADJ
admet-376	623	18	drugs	drug	NOUN
admet-376	623	19	from	from	ADP
admet-376	623	20	1981	1981	NUM
admet-376	623	21	to	to	ADP
admet-376	623	22	2014	2014	NUM
admet-376	623	23	,	,	PUNCT
admet-376	623	24	j	j	PROPN
admet-376	623	25	nat	nat	PROPN
admet-376	623	26	prod	prod	VERB
admet-376	623	27	79	79	NUM
admet-376	623	28	(	(	PUNCT
admet-376	623	29	2016	2016	NUM
admet-376	623	30	)	)	PUNCT
admet-376	623	31	629	629	NUM
admet-376	623	32	-	-	SYM
admet-376	623	33	661	661	NUM
admet-376	623	34	.	.	PUNCT
admet-376	624	1	[	[	X
admet-376	624	2	159	159	NUM
admet-376	624	3	]	]	X
admet-376	624	4	t.i	t.i	PROPN
admet-376	624	5	.	.	PROPN
admet-376	624	6	oprea	oprea	PROPN
admet-376	624	7	,	,	PUNCT
admet-376	624	8	a.m.	a.m.	PROPN
admet-376	624	9	davis	davis	PROPN
admet-376	624	10	,	,	PUNCT
admet-376	624	11	s.j	s.j	PROPN
admet-376	624	12	.	.	PROPN
admet-376	624	13	teague	teague	PROPN
admet-376	624	14	,	,	PUNCT
admet-376	624	15	p.d	p.d	PROPN
admet-376	624	16	.	.	PROPN
admet-376	624	17	leeson	leeson	PROPN
admet-376	624	18	.	.	PUNCT
admet-376	624	19	is	be	AUX
admet-376	624	20	there	there	PRON
admet-376	624	21	a	a	DET
admet-376	624	22	difference	difference	NOUN
admet-376	624	23	between	between	ADP
admet-376	624	24	leads	lead	NOUN
admet-376	624	25	and	and	CCONJ
admet-376	624	26	drugs	drug	NOUN
admet-376	624	27	?	?	PUNCT
admet-376	625	1	a	a	DET
admet-376	625	2	historical	historical	ADJ
admet-376	625	3	perspective	perspective	NOUN
admet-376	625	4	,	,	PUNCT
admet-376	625	5	j	j	PROPN
admet-376	625	6	chem	chem	PROPN
admet-376	625	7	inf	inf	PROPN
admet-376	625	8	comp	comp	NOUN
admet-376	625	9	sci	sci	PROPN
admet-376	625	10	41	41	NUM
admet-376	625	11	(	(	PUNCT
admet-376	625	12	2001	2001	NUM
admet-376	625	13	)	)	PUNCT
admet-376	625	14	1308	1308	NUM
admet-376	625	15	-	-	SYM
admet-376	625	16	1315	1315	NUM
admet-376	625	17	.	.	PUNCT
admet-376	626	1	[	[	X
admet-376	626	2	160	160	NUM
admet-376	626	3	]	]	X
admet-376	626	4	t.i	t.i	PROPN
admet-376	626	5	.	.	PROPN
admet-376	626	6	oprea	oprea	PROPN
admet-376	626	7	,	,	PUNCT
admet-376	626	8	t.k	t.k	PROPN
admet-376	626	9	.	.	PROPN
admet-376	626	10	allu	allu	PROPN
admet-376	626	11	,	,	PUNCT
admet-376	626	12	d.c	d.c	PROPN
admet-376	626	13	.	.	PROPN
admet-376	626	14	fara	fara	PROPN
admet-376	626	15	,	,	PUNCT
admet-376	626	16	r.f	r.f	PROPN
admet-376	626	17	.	.	PROPN
admet-376	626	18	rad	rad	PROPN
admet-376	626	19	,	,	PUNCT
admet-376	626	20	l.	l.	PROPN
admet-376	626	21	ostopovici	ostopovici	PROPN
admet-376	626	22	,	,	PUNCT
admet-376	626	23	c.g	c.g	PROPN
admet-376	626	24	.	.	PROPN
admet-376	626	25	bologa	bologa	NOUN
admet-376	626	26	.	.	PUNCT
admet-376	627	1	lead	lead	NOUN
admet-376	627	2	-	-	PUNCT
admet-376	627	3	like	like	ADJ
admet-376	627	4	,	,	PUNCT
admet-376	627	5	drug	drug	NOUN
admet-376	627	6	-	-	PUNCT
admet-376	627	7	like	like	ADJ
admet-376	627	8	or	or	CCONJ
admet-376	627	9	"	"	PUNCT
admet-376	627	10	pub	pub	NOUN
admet-376	627	11	-	-	PUNCT
admet-376	627	12	like	like	ADJ
admet-376	627	13	"	"	PUNCT
admet-376	627	14	:	:	PUNCT
admet-376	627	15	how	how	SCONJ
admet-376	627	16	different	different	ADJ
admet-376	627	17	are	be	AUX
admet-376	627	18	they	they	PRON
admet-376	627	19	?	?	PUNCT
admet-376	627	20	,	,	PUNCT
admet-376	627	21	j	j	PROPN
admet-376	627	22	comput	comput	NOUN
admet-376	627	23	aided	aid	VERB
admet-376	627	24	mol	mol	ADP
admet-376	627	25	des	des	PROPN
admet-376	627	26	21	21	NUM
admet-376	627	27	(	(	PUNCT
admet-376	627	28	2007	2007	NUM
admet-376	627	29	)	)	PUNCT
admet-376	627	30	113	113	NUM
admet-376	627	31	-	-	SYM
admet-376	627	32	119	119	NUM
admet-376	627	33	.	.	PUNCT
admet-376	628	1	[	[	X
admet-376	628	2	161	161	NUM
admet-376	628	3	]	]	PUNCT
admet-376	628	4	r.	r.	PROPN
admet-376	628	5	van	van	PROPN
admet-376	628	6	deursen	deursen	PROPN
admet-376	628	7	,	,	PUNCT
admet-376	628	8	l.c	l.c	PROPN
admet-376	628	9	.	.	PROPN
admet-376	628	10	blum	blum	PROPN
admet-376	628	11	,	,	PUNCT
admet-376	628	12	j.l	j.l	PROPN
admet-376	628	13	.	.	PROPN
admet-376	628	14	reymond	reymond	PROPN
admet-376	628	15	.	.	PUNCT
admet-376	629	1	visualisation	visualisation	NOUN
admet-376	629	2	of	of	ADP
admet-376	629	3	the	the	DET
admet-376	629	4	chemical	chemical	NOUN
admet-376	629	5	space	space	NOUN
admet-376	629	6	of	of	ADP
admet-376	629	7	fragments	fragment	NOUN
admet-376	629	8	,	,	PUNCT
admet-376	629	9	lead	lead	NOUN
admet-376	629	10	-	-	PUNCT
admet-376	629	11	like	like	ADP
admet-376	629	12	and	and	CCONJ
admet-376	629	13	drug	drug	NOUN
admet-376	629	14	-	-	PUNCT
admet-376	629	15	like	like	ADJ
admet-376	629	16	molecules	molecule	NOUN
admet-376	629	17	in	in	ADP
admet-376	629	18	pubchem	pubchem	NOUN
admet-376	629	19	,	,	PUNCT
admet-376	629	20	j	j	PROPN
admet-376	629	21	comput	comput	NOUN
admet-376	629	22	aided	aid	VERB
admet-376	629	23	mol	mol	ADP
admet-376	629	24	des	des	PROPN
admet-376	629	25	25	25	NUM
admet-376	629	26	(	(	PUNCT
admet-376	629	27	2011	2011	NUM
admet-376	629	28	)	)	PUNCT
admet-376	629	29	649	649	NUM
admet-376	629	30	-	-	SYM
admet-376	629	31	662	662	NUM
admet-376	629	32	.	.	PUNCT
admet-376	630	1	[	[	X
admet-376	630	2	162	162	NUM
admet-376	630	3	]	]	PUNCT
admet-376	630	4	t.	t.	PROPN
admet-376	630	5	wunberg	wunberg	PROPN
admet-376	630	6	,	,	PUNCT
admet-376	630	7	m.	m.	NOUN
admet-376	630	8	hendrix	hendrix	PROPN
admet-376	630	9	,	,	PUNCT
admet-376	630	10	a.	a.	NOUN
admet-376	630	11	hillisch	hillisch	PROPN
admet-376	630	12	,	,	PUNCT
admet-376	630	13	m.	m.	NOUN
admet-376	630	14	lobell	lobell	PROPN
admet-376	630	15	,	,	PUNCT
admet-376	630	16	h.	h.	PROPN
admet-376	630	17	meier	meier	PROPN
admet-376	630	18	,	,	PUNCT
admet-376	630	19	c.	c.	PROPN
admet-376	630	20	schmeck	schmeck	PROPN
admet-376	630	21	,	,	PUNCT
admet-376	630	22	h.	h.	PROPN
admet-376	630	23	wild	wild	PROPN
admet-376	630	24	,	,	PUNCT
admet-376	630	25	b.	b.	PROPN
admet-376	630	26	hinzen	hinzen	PROPN
admet-376	630	27	.	.	PUNCT
admet-376	631	1	improving	improve	VERB
admet-376	631	2	the	the	DET
admet-376	631	3	hit	hit	NOUN
admet-376	631	4	-	-	PUNCT
admet-376	631	5	to	to	ADP
admet-376	631	6	-	-	PUNCT
admet-376	631	7	lead	lead	NOUN
admet-376	631	8	process	process	NOUN
admet-376	631	9	:	:	PUNCT
admet-376	631	10	data	data	NOUN
admet-376	631	11	-	-	PUNCT
admet-376	631	12	driven	drive	VERB
admet-376	631	13	assessment	assessment	NOUN
admet-376	631	14	of	of	ADP
admet-376	631	15	drug	drug	NOUN
admet-376	631	16	-	-	PUNCT
admet-376	631	17	like	like	ADJ
admet-376	631	18	and	and	CCONJ
admet-376	631	19	lead	lead	NOUN
admet-376	631	20	-	-	PUNCT
admet-376	631	21	like	like	ADJ
admet-376	631	22	screening	screening	NOUN
admet-376	631	23	hits	hit	NOUN
admet-376	631	24	,	,	PUNCT
admet-376	631	25	drug	drug	NOUN
admet-376	631	26	discov	discov	NOUN
admet-376	631	27	today	today	NOUN
admet-376	631	28	11	11	NUM
admet-376	631	29	(	(	PUNCT
admet-376	631	30	2006	2006	NUM
admet-376	631	31	)	)	PUNCT
admet-376	631	32	175	175	NUM
admet-376	631	33	-	-	SYM
admet-376	631	34	180	180	NUM
admet-376	631	35	.	.	PUNCT
admet-376	632	1	[	[	X
admet-376	632	2	163	163	NUM
admet-376	632	3	]	]	PUNCT
admet-376	632	4	b.	b.	PROPN
admet-376	632	5	schulz	schulz	PROPN
admet-376	632	6	,	,	PUNCT
admet-376	632	7	h.ü	h.ü	PROPN
admet-376	632	8	.	.	PROPN
admet-376	632	9	kolukisaoglu	kolukisaoglu	PROPN
admet-376	632	10	.	.	PUNCT
admet-376	633	1	genomics	genomic	NOUN
admet-376	633	2	of	of	ADP
admet-376	633	3	plant	plant	NOUN
admet-376	633	4	abc	abc	PROPN
admet-376	633	5	transporters	transporter	NOUN
admet-376	633	6	:	:	PUNCT
admet-376	633	7	the	the	DET
admet-376	633	8	alphabet	alphabet	NOUN
admet-376	633	9	of	of	ADP
admet-376	633	10	photosynthetic	photosynthetic	ADJ
admet-376	633	11	life	life	NOUN
admet-376	633	12	forms	form	NOUN
admet-376	633	13	or	or	CCONJ
admet-376	633	14	just	just	ADV
admet-376	633	15	holes	hole	NOUN
admet-376	633	16	in	in	ADP
admet-376	633	17	membranes	membrane	NOUN
admet-376	633	18	?	?	PUNCT
admet-376	633	19	,	,	PUNCT
admet-376	633	20	febs	febs	NOUN
admet-376	633	21	lett	lett	PROPN
admet-376	633	22	580	580	NUM
admet-376	633	23	(	(	PUNCT
admet-376	633	24	2006	2006	NUM
admet-376	633	25	)	)	PUNCT
admet-376	633	26	1010	1010	NUM
admet-376	633	27	-	-	SYM
admet-376	633	28	1016	1016	NUM
admet-376	633	29	.	.	PUNCT
admet-376	634	1	[	[	X
admet-376	634	2	164	164	NUM
admet-376	634	3	]	]	X
admet-376	634	4	n.	n.	NOUN
admet-376	634	5	shitan	shitan	PROPN
admet-376	634	6	,	,	PUNCT
admet-376	634	7	k.	k.	PROPN
admet-376	634	8	yazaki	yazaki	PROPN
admet-376	634	9	.	.	PUNCT
admet-376	635	1	new	new	ADJ
admet-376	635	2	insights	insight	NOUN
admet-376	635	3	into	into	ADP
admet-376	635	4	the	the	DET
admet-376	635	5	transport	transport	NOUN
admet-376	635	6	mechanisms	mechanism	NOUN
admet-376	635	7	in	in	ADP
admet-376	635	8	plant	plant	NOUN
admet-376	635	9	vacuoles	vacuole	NOUN
admet-376	635	10	,	,	PUNCT
admet-376	635	11	int	int	NOUN
admet-376	635	12	rev	rev	PROPN
admet-376	635	13	cell	cell	NOUN
admet-376	635	14	mol	mol	ADP
admet-376	635	15	biol	biol	PROPN
admet-376	635	16	305	305	NUM
admet-376	635	17	(	(	PUNCT
admet-376	635	18	2013	2013	NUM
admet-376	635	19	)	)	PUNCT
admet-376	635	20	383	383	NUM
admet-376	635	21	-	-	SYM
admet-376	635	22	433	433	NUM
admet-376	635	23	.	.	PUNCT
admet-376	636	1	[	[	X
admet-376	636	2	165	165	NUM
admet-376	636	3	]	]	PUNCT
admet-376	636	4	k.	k.	NOUN
admet-376	636	5	yazaki	yazaki	PROPN
admet-376	636	6	.	.	PUNCT
admet-376	637	1	abc	abc	PROPN
admet-376	637	2	transporters	transporter	NOUN
admet-376	637	3	involved	involve	VERB
admet-376	637	4	in	in	ADP
admet-376	637	5	the	the	DET
admet-376	637	6	transport	transport	NOUN
admet-376	637	7	of	of	ADP
admet-376	637	8	plant	plant	NOUN
admet-376	637	9	secondary	secondary	ADJ
admet-376	637	10	metabolites	metabolite	NOUN
admet-376	637	11	,	,	PUNCT
admet-376	637	12	febs	febs	NOUN
admet-376	637	13	lett	lett	NOUN
admet-376	637	14	580	580	NUM
admet-376	637	15	(	(	PUNCT
admet-376	637	16	2006	2006	NUM
admet-376	637	17	)	)	PUNCT
admet-376	637	18	1183	1183	NUM
admet-376	637	19	-	-	SYM
admet-376	637	20	1191	1191	NUM
admet-376	637	21	.	.	PUNCT
admet-376	638	1	[	[	X
admet-376	638	2	166	166	NUM
admet-376	638	3	]	]	X
admet-376	638	4	j.j	j.j	PROPN
admet-376	638	5	.	.	PROPN
admet-376	638	6	mousa	mousa	PROPN
admet-376	638	7	,	,	PUNCT
admet-376	638	8	s.d	s.d	PROPN
admet-376	638	9	.	.	PROPN
admet-376	638	10	bruner	bruner	PROPN
admet-376	638	11	.	.	PUNCT
admet-376	639	1	structural	structural	ADJ
admet-376	639	2	and	and	CCONJ
admet-376	639	3	mechanistic	mechanistic	ADJ
admet-376	639	4	diversity	diversity	NOUN
admet-376	639	5	of	of	ADP
admet-376	639	6	multidrug	multidrug	NOUN
admet-376	639	7	transporters	transporter	NOUN
admet-376	639	8	,	,	PUNCT
admet-376	639	9	nat	nat	PROPN
admet-376	639	10	prod	prod	PROPN
admet-376	639	11	rep	rep	PROPN
admet-376	639	12	33	33	NUM
admet-376	639	13	(	(	PUNCT
admet-376	639	14	2016	2016	NUM
admet-376	639	15	)	)	PUNCT
admet-376	639	16	1255	1255	NUM
admet-376	639	17	-	-	SYM
admet-376	639	18	1267	1267	NUM
admet-376	639	19	.	.	PUNCT
admet-376	640	1	[	[	X
admet-376	640	2	167	167	NUM
admet-376	640	3	]	]	X
admet-376	640	4	r.e	r.e	PROPN
admet-376	640	5	.	.	PROPN
admet-376	640	6	lenski	lenski	PROPN
admet-376	640	7	,	,	PUNCT
admet-376	640	8	c.	c.	PROPN
admet-376	640	9	ofria	ofria	PROPN
admet-376	640	10	,	,	PUNCT
admet-376	640	11	r.t	r.t	PROPN
admet-376	640	12	.	.	PROPN
admet-376	640	13	pennock	pennock	PROPN
admet-376	640	14	,	,	PUNCT
admet-376	640	15	c.	c.	PROPN
admet-376	640	16	adami	adami	PROPN
admet-376	640	17	.	.	PUNCT
admet-376	641	1	the	the	DET
admet-376	641	2	evolutionary	evolutionary	ADJ
admet-376	641	3	origin	origin	NOUN
admet-376	641	4	of	of	ADP
admet-376	641	5	complex	complex	ADJ
admet-376	641	6	features	feature	NOUN
admet-376	641	7	,	,	PUNCT
admet-376	641	8	nature	nature	NOUN
admet-376	641	9	423	423	NUM
admet-376	641	10	(	(	PUNCT
admet-376	641	11	2003	2003	NUM
admet-376	641	12	)	)	PUNCT
admet-376	641	13	139	139	NUM
admet-376	641	14	-	-	SYM
admet-376	641	15	144	144	NUM
admet-376	641	16	.	.	PUNCT
admet-376	642	1	[	[	X
admet-376	642	2	168	168	NUM
admet-376	642	3	]	]	PUNCT
admet-376	642	4	a.	a.	NOUN
admet-376	642	5	currin	currin	NOUN
admet-376	642	6	,	,	PUNCT
admet-376	642	7	n.	n.	PROPN
admet-376	642	8	swainston	swainston	PROPN
admet-376	642	9	,	,	PUNCT
admet-376	642	10	p.j	p.j	PROPN
admet-376	642	11	.	.	PROPN
admet-376	642	12	day	day	PROPN
admet-376	642	13	,	,	PUNCT
admet-376	642	14	d.b	d.b	PROPN
admet-376	642	15	.	.	PROPN
admet-376	642	16	kell	kell	PROPN
admet-376	642	17	.	.	PUNCT
admet-376	643	1	synthetic	synthetic	ADJ
admet-376	643	2	biology	biology	NOUN
admet-376	643	3	for	for	ADP
admet-376	643	4	the	the	DET
admet-376	643	5	directed	direct	VERB
admet-376	643	6	evolution	evolution	NOUN
admet-376	643	7	of	of	ADP
admet-376	643	8	protein	protein	NOUN
admet-376	643	9	biocatalysts	biocatalyst	NOUN
admet-376	643	10	:	:	PUNCT
admet-376	643	11	navigating	navigate	VERB
admet-376	643	12	sequence	sequence	NOUN
admet-376	643	13	space	space	NOUN
admet-376	643	14	intelligently	intelligently	ADV
admet-376	643	15	,	,	PUNCT
admet-376	643	16	chem	chem	NOUN
admet-376	643	17	soc	soc	NOUN
admet-376	643	18	rev	rev	VERB
admet-376	643	19	44	44	NUM
admet-376	643	20	(	(	PUNCT
admet-376	643	21	2015	2015	NUM
admet-376	643	22	)	)	PUNCT
admet-376	643	23	1172	1172	NUM
admet-376	643	24	-	-	SYM
admet-376	643	25	1239	1239	NUM
admet-376	643	26	.	.	PUNCT
admet-376	643	27	o'hagan	o'hagan	PROPN
admet-376	643	28	&	&	CCONJ
admet-376	643	29	kell	kell	PROPN
admet-376	643	30	admet	admet	PROPN
admet-376	643	31	&	&	CCONJ
admet-376	643	32	dmpk	dmpk	PROPN
admet-376	643	33	5(2	5(2	NUM
admet-376	643	34	)	)	PUNCT
admet-376	643	35	(	(	PUNCT
admet-376	643	36	2017	2017	NUM
admet-376	643	37	)	)	PUNCT
admet-376	643	38	85	85	NUM
admet-376	643	39	-	-	SYM
admet-376	643	40	125	125	NUM
admet-376	643	41	122	122	NUM
admet-376	643	42	[	[	SYM
admet-376	643	43	169	169	NUM
admet-376	643	44	]	]	X
admet-376	643	45	o.	o.	PROPN
admet-376	643	46	tenaillon	tenaillon	PROPN
admet-376	643	47	,	,	PUNCT
admet-376	643	48	j.e	j.e	PROPN
admet-376	643	49	.	.	PROPN
admet-376	643	50	barrick	barrick	PROPN
admet-376	643	51	,	,	PUNCT
admet-376	643	52	n.	n.	PROPN
admet-376	643	53	ribeck	ribeck	PROPN
admet-376	643	54	,	,	PUNCT
admet-376	643	55	d.e	d.e	PROPN
admet-376	643	56	.	.	PROPN
admet-376	643	57	deatherage	deatherage	NOUN
admet-376	643	58	,	,	PUNCT
admet-376	643	59	j.l	j.l	PROPN
admet-376	643	60	.	.	PROPN
admet-376	643	61	blanchard	blanchard	PROPN
admet-376	643	62	,	,	PUNCT
admet-376	643	63	a.	a.	PROPN
admet-376	643	64	dasgupta	dasgupta	PROPN
admet-376	643	65	,	,	PUNCT
admet-376	643	66	g.c	g.c	PROPN
admet-376	643	67	.	.	PROPN
admet-376	643	68	wu	wu	PROPN
admet-376	643	69	,	,	PUNCT
admet-376	643	70	s.	s.	PROPN
admet-376	643	71	wielgoss	wielgoss	PROPN
admet-376	643	72	,	,	PUNCT
admet-376	643	73	s.	s.	PROPN
admet-376	643	74	cruveiller	cruveiller	PROPN
admet-376	643	75	,	,	PUNCT
admet-376	643	76	c.	c.	PROPN
admet-376	643	77	médigue	médigue	PROPN
admet-376	643	78	,	,	PUNCT
admet-376	643	79	d.	d.	PROPN
admet-376	643	80	schneider	schneider	PROPN
admet-376	643	81	,	,	PUNCT
admet-376	643	82	r.e	r.e	PROPN
admet-376	643	83	.	.	PROPN
admet-376	643	84	lenski	lenski	PROPN
admet-376	643	85	.	.	PUNCT
admet-376	644	1	tempo	tempo	NOUN
admet-376	644	2	and	and	CCONJ
admet-376	644	3	mode	mode	NOUN
admet-376	644	4	of	of	ADP
admet-376	644	5	genome	genome	NOUN
admet-376	644	6	evolution	evolution	NOUN
admet-376	644	7	in	in	ADP
admet-376	644	8	a	a	DET
admet-376	644	9	50,000	50,000	NUM
admet-376	644	10	-	-	PUNCT
admet-376	644	11	generation	generation	NOUN
admet-376	644	12	experiment	experiment	NOUN
admet-376	644	13	,	,	PUNCT
admet-376	644	14	nature	nature	NOUN
admet-376	644	15	(	(	PUNCT
admet-376	644	16	2016	2016	NUM
admet-376	644	17	)	)	PUNCT
admet-376	644	18	.	.	PUNCT
admet-376	645	1	[	[	X
admet-376	645	2	170	170	NUM
admet-376	645	3	]	]	X
admet-376	645	4	p.	p.	NOUN
admet-376	645	5	ertl	ertl	PROPN
admet-376	645	6	,	,	PUNCT
admet-376	645	7	a.	a.	NOUN
admet-376	645	8	schuffenhauer	schuffenhauer	NOUN
admet-376	645	9	.	.	PUNCT
admet-376	646	1	cheminformatics	cheminformatic	NOUN
admet-376	646	2	analysis	analysis	NOUN
admet-376	646	3	of	of	ADP
admet-376	646	4	natural	natural	ADJ
admet-376	646	5	products	product	NOUN
admet-376	646	6	:	:	PUNCT
admet-376	646	7	lessons	lesson	NOUN
admet-376	646	8	from	from	ADP
admet-376	646	9	nature	nature	NOUN
admet-376	646	10	inspiring	inspire	VERB
admet-376	646	11	the	the	DET
admet-376	646	12	design	design	NOUN
admet-376	646	13	of	of	ADP
admet-376	646	14	new	new	ADJ
admet-376	646	15	drugs	drug	NOUN
admet-376	646	16	,	,	PUNCT
admet-376	646	17	prog	prog	NOUN
admet-376	646	18	drug	drug	NOUN
admet-376	646	19	res	re	NOUN
admet-376	646	20	66	66	NUM
admet-376	646	21	(	(	PUNCT
admet-376	646	22	2008	2008	NUM
admet-376	646	23	)	)	PUNCT
admet-376	646	24	217	217	NUM
admet-376	646	25	,	,	PUNCT
admet-376	646	26	219	219	NUM
admet-376	646	27	-	-	SYM
admet-376	646	28	235	235	NUM
admet-376	646	29	.	.	PUNCT
admet-376	647	1	[	[	X
admet-376	647	2	171	171	NUM
admet-376	647	3	]	]	X
admet-376	647	4	p.	p.	NOUN
admet-376	647	5	ertl	ertl	PROPN
admet-376	647	6	,	,	PUNCT
admet-376	647	7	s.	s.	PROPN
admet-376	647	8	roggo	roggo	PROPN
admet-376	647	9	,	,	PUNCT
admet-376	647	10	a.	a.	NOUN
admet-376	647	11	schuffenhauer	schuffenhauer	NOUN
admet-376	647	12	.	.	PUNCT
admet-376	647	13	natural	natural	ADJ
admet-376	647	14	product	product	NOUN
admet-376	647	15	-	-	PUNCT
admet-376	647	16	likeness	likeness	NOUN
admet-376	647	17	score	score	NOUN
admet-376	647	18	and	and	CCONJ
admet-376	647	19	its	its	PRON
admet-376	647	20	application	application	NOUN
admet-376	647	21	for	for	ADP
admet-376	647	22	prioritization	prioritization	NOUN
admet-376	647	23	of	of	ADP
admet-376	647	24	compound	compound	NOUN
admet-376	647	25	libraries	library	NOUN
admet-376	647	26	,	,	PUNCT
admet-376	647	27	j	j	PROPN
admet-376	647	28	chem	chem	PROPN
admet-376	647	29	inf	inf	PROPN
admet-376	647	30	model	model	NOUN
admet-376	647	31	48	48	NUM
admet-376	647	32	(	(	PUNCT
admet-376	647	33	2008	2008	NUM
admet-376	647	34	)	)	PUNCT
admet-376	647	35	68	68	NUM
admet-376	647	36	-	-	SYM
admet-376	647	37	74	74	NUM
admet-376	647	38	.	.	PUNCT
admet-376	648	1	[	[	X
admet-376	648	2	172	172	NUM
admet-376	648	3	]	]	X
admet-376	648	4	d.j	d.j	PROPN
admet-376	648	5	.	.	PROPN
admet-376	648	6	newman	newman	PROPN
admet-376	648	7	,	,	PUNCT
admet-376	648	8	g.m	g.m	PROPN
admet-376	648	9	.	.	PROPN
admet-376	648	10	cragg	cragg	PROPN
admet-376	648	11	,	,	PUNCT
admet-376	648	12	natural	natural	ADJ
admet-376	648	13	product	product	NOUN
admet-376	648	14	scaffolds	scaffold	NOUN
admet-376	648	15	of	of	ADP
admet-376	648	16	value	value	NOUN
admet-376	648	17	in	in	ADP
admet-376	648	18	medicinal	medicinal	ADJ
admet-376	648	19	chemistry	chemistry	NOUN
admet-376	648	20	in	in	ADP
admet-376	648	21	:	:	PUNCT
admet-376	648	22	s.	s.	PROPN
admet-376	648	23	bräse	bräse	PROPN
admet-376	648	24	(	(	PUNCT
admet-376	648	25	ed	ed	NOUN
admet-376	648	26	.	.	PUNCT
admet-376	648	27	)	)	PUNCT
admet-376	649	1	privileged	privileged	ADJ
admet-376	649	2	scaffolds	scaffold	NOUN
admet-376	649	3	in	in	ADP
admet-376	649	4	medicinal	medicinal	ADJ
admet-376	649	5	chemistry	chemistry	NOUN
admet-376	649	6	:	:	PUNCT
admet-376	649	7	design	design	NOUN
admet-376	649	8	,	,	PUNCT
admet-376	649	9	synthesis	synthesis	NOUN
admet-376	649	10	,	,	PUNCT
admet-376	649	11	evaluation	evaluation	NOUN
admet-376	649	12	,	,	PUNCT
admet-376	649	13	rsc	rsc	PROPN
admet-376	649	14	,	,	PUNCT
admet-376	649	15	london	london	PROPN
admet-376	649	16	,	,	PUNCT
admet-376	649	17	2016	2016	NUM
admet-376	649	18	,	,	PUNCT
admet-376	649	19	pp	pp	ADJ
admet-376	649	20	.	.	PUNCT
admet-376	650	1	348	348	NUM
admet-376	650	2	-	-	SYM
admet-376	650	3	378	378	NUM
admet-376	650	4	.	.	PUNCT
admet-376	651	1	[	[	X
admet-376	651	2	173	173	NUM
admet-376	651	3	]	]	X
admet-376	651	4	b.m	b.m	PROPN
admet-376	651	5	.	.	PROPN
admet-376	651	6	schmidt	schmidt	PROPN
admet-376	651	7	,	,	PUNCT
admet-376	651	8	d.m	d.m	PROPN
admet-376	651	9	.	.	PUNCT
admet-376	652	1	ribnicky	ribnicky	PROPN
admet-376	652	2	,	,	PUNCT
admet-376	652	3	p.e	p.e	PROPN
admet-376	652	4	.	.	PROPN
admet-376	652	5	lipsky	lipsky	PROPN
admet-376	652	6	,	,	PUNCT
admet-376	652	7	i.	i.	PROPN
admet-376	652	8	raskin	raskin	PROPN
admet-376	652	9	.	.	PUNCT
admet-376	653	1	revisiting	revisit	VERB
admet-376	653	2	the	the	DET
admet-376	653	3	ancient	ancient	ADJ
admet-376	653	4	concept	concept	NOUN
admet-376	653	5	of	of	ADP
admet-376	653	6	botanical	botanical	ADJ
admet-376	653	7	therapeutics	therapeutic	NOUN
admet-376	653	8	,	,	PUNCT
admet-376	653	9	nat	nat	PROPN
admet-376	653	10	chem	chem	NOUN
admet-376	653	11	biol	biol	NOUN
admet-376	653	12	3	3	NUM
admet-376	653	13	(	(	PUNCT
admet-376	653	14	2007	2007	NUM
admet-376	653	15	)	)	PUNCT
admet-376	653	16	360	360	NUM
admet-376	653	17	-	-	SYM
admet-376	653	18	366	366	NUM
admet-376	653	19	.	.	PUNCT
admet-376	654	1	[	[	X
admet-376	654	2	174	174	NUM
admet-376	654	3	]	]	PUNCT
admet-376	654	4	t.	t.	PROPN
admet-376	654	5	bersaglieri	bersaglieri	PROPN
admet-376	654	6	,	,	PUNCT
admet-376	654	7	p.c	p.c	PROPN
admet-376	654	8	.	.	PROPN
admet-376	654	9	sabeti	sabeti	PROPN
admet-376	654	10	,	,	PUNCT
admet-376	654	11	n.	n.	PROPN
admet-376	654	12	patterson	patterson	PROPN
admet-376	654	13	,	,	PUNCT
admet-376	654	14	t.	t.	PROPN
admet-376	654	15	vanderploeg	vanderploeg	PROPN
admet-376	654	16	,	,	PUNCT
admet-376	654	17	s.f	s.f	PROPN
admet-376	654	18	.	.	PROPN
admet-376	654	19	schaffner	schaffner	PROPN
admet-376	654	20	,	,	PUNCT
admet-376	654	21	j.a	j.a	PROPN
admet-376	654	22	.	.	PROPN
admet-376	654	23	drake	drake	PROPN
admet-376	654	24	,	,	PUNCT
admet-376	654	25	m.	m.	NOUN
admet-376	654	26	rhodes	rhodes	PROPN
admet-376	654	27	,	,	PUNCT
admet-376	654	28	d.e	d.e	PROPN
admet-376	654	29	.	.	PROPN
admet-376	654	30	reich	reich	PROPN
admet-376	654	31	,	,	PUNCT
admet-376	654	32	j.n	j.n	PROPN
admet-376	654	33	.	.	PROPN
admet-376	654	34	hirschhorn	hirschhorn	PROPN
admet-376	654	35	.	.	PUNCT
admet-376	655	1	genetic	genetic	ADJ
admet-376	655	2	signatures	signature	NOUN
admet-376	655	3	of	of	ADP
admet-376	655	4	strong	strong	ADJ
admet-376	655	5	recent	recent	ADJ
admet-376	655	6	positive	positive	ADJ
admet-376	655	7	selection	selection	NOUN
admet-376	655	8	at	at	ADP
admet-376	655	9	the	the	DET
admet-376	655	10	lactase	lactase	NOUN
admet-376	655	11	gene	gene	NOUN
admet-376	655	12	,	,	PUNCT
admet-376	655	13	am	be	AUX
admet-376	655	14	j	j	PROPN
admet-376	655	15	hum	hum	PROPN
admet-376	655	16	genet	genet	PROPN
admet-376	655	17	74	74	NUM
admet-376	655	18	(	(	PUNCT
admet-376	655	19	2004	2004	NUM
admet-376	655	20	)	)	PUNCT
admet-376	655	21	1111	1111	NUM
admet-376	655	22	-	-	SYM
admet-376	655	23	1120	1120	NUM
admet-376	655	24	.	.	PUNCT
admet-376	656	1	[	[	X
admet-376	656	2	175	175	NUM
admet-376	656	3	]	]	X
admet-376	656	4	e.e	e.e	PROPN
admet-376	656	5	.	.	PROPN
admet-376	656	6	harris	harris	PROPN
admet-376	656	7	,	,	PUNCT
admet-376	656	8	d.	d.	PROPN
admet-376	656	9	meyer	meyer	PROPN
admet-376	656	10	.	.	PUNCT
admet-376	657	1	the	the	DET
admet-376	657	2	molecular	molecular	ADJ
admet-376	657	3	signature	signature	NOUN
admet-376	657	4	of	of	ADP
admet-376	657	5	selection	selection	NOUN
admet-376	657	6	underlying	underlie	VERB
admet-376	657	7	human	human	ADJ
admet-376	657	8	adaptations	adaptation	NOUN
admet-376	657	9	,	,	PUNCT
admet-376	657	10	am	be	AUX
admet-376	657	11	j	j	PROPN
admet-376	657	12	phys	phy	NOUN
admet-376	657	13	anthropol	anthropol	NOUN
admet-376	657	14	suppl	suppl	PROPN
admet-376	657	15	43	43	NUM
admet-376	657	16	(	(	PUNCT
admet-376	657	17	2006	2006	NUM
admet-376	657	18	)	)	PUNCT
admet-376	657	19	89	89	NUM
admet-376	657	20	-	-	SYM
admet-376	657	21	130	130	NUM
admet-376	657	22	.	.	PUNCT
admet-376	658	1	[	[	X
admet-376	658	2	176	176	X
admet-376	658	3	]	]	X
admet-376	658	4	p.	p.	NOUN
admet-376	658	5	gerbault	gerbault	PROPN
admet-376	658	6	,	,	PUNCT
admet-376	658	7	a.	a.	PROPN
admet-376	658	8	liebert	liebert	PROPN
admet-376	658	9	,	,	PUNCT
admet-376	658	10	y.	y.	PROPN
admet-376	658	11	itan	itan	PROPN
admet-376	658	12	,	,	PUNCT
admet-376	658	13	a.	a.	NOUN
admet-376	658	14	powell	powell	PROPN
admet-376	658	15	,	,	PUNCT
admet-376	658	16	m.	m.	NOUN
admet-376	658	17	currat	currat	PROPN
admet-376	658	18	,	,	PUNCT
admet-376	658	19	j.	j.	PROPN
admet-376	658	20	burger	burger	PROPN
admet-376	658	21	,	,	PUNCT
admet-376	658	22	d.m	d.m	PROPN
admet-376	658	23	.	.	PUNCT
admet-376	659	1	swallow	swallow	PROPN
admet-376	659	2	,	,	PUNCT
admet-376	659	3	m.g	m.g	PROPN
admet-376	659	4	.	.	PROPN
admet-376	659	5	thomas	thomas	PROPN
admet-376	659	6	.	.	PUNCT
admet-376	660	1	evolution	evolution	NOUN
admet-376	660	2	of	of	ADP
admet-376	660	3	lactase	lactase	NOUN
admet-376	660	4	persistence	persistence	NOUN
admet-376	660	5	:	:	PUNCT
admet-376	660	6	an	an	DET
admet-376	660	7	example	example	NOUN
admet-376	660	8	of	of	ADP
admet-376	660	9	human	human	ADJ
admet-376	660	10	niche	niche	NOUN
admet-376	660	11	construction	construction	NOUN
admet-376	660	12	,	,	PUNCT
admet-376	660	13	philos	philo	VERB
admet-376	660	14	trans	trans	PROPN
admet-376	660	15	r	r	PROPN
admet-376	660	16	soc	soc	PROPN
admet-376	660	17	lond	lond	PROPN
admet-376	660	18	b	b	PROPN
admet-376	660	19	biol	biol	PROPN
admet-376	660	20	sci	sci	PROPN
admet-376	660	21	366	366	NUM
admet-376	660	22	(	(	PUNCT
admet-376	660	23	2011	2011	NUM
admet-376	660	24	)	)	PUNCT
admet-376	660	25	863	863	NUM
admet-376	660	26	-	-	SYM
admet-376	660	27	877	877	NUM
admet-376	660	28	.	.	PUNCT
admet-376	661	1	[	[	X
admet-376	661	2	177	177	NUM
admet-376	661	3	]	]	PUNCT
admet-376	661	4	j.	j.	PROPN
admet-376	661	5	walter	walter	PROPN
admet-376	661	6	,	,	PUNCT
admet-376	661	7	r.	r.	PROPN
admet-376	661	8	ley	ley	PROPN
admet-376	661	9	.	.	PUNCT
admet-376	662	1	the	the	DET
admet-376	662	2	human	human	ADJ
admet-376	662	3	gut	gut	NOUN
admet-376	662	4	microbiome	microbiome	NOUN
admet-376	662	5	:	:	PUNCT
admet-376	662	6	ecology	ecology	NOUN
admet-376	662	7	and	and	CCONJ
admet-376	662	8	recent	recent	ADJ
admet-376	662	9	evolutionary	evolutionary	ADJ
admet-376	662	10	changes	change	NOUN
admet-376	662	11	,	,	PUNCT
admet-376	662	12	annu	annu	X
admet-376	662	13	rev	rev	VERB
admet-376	662	14	microbiol	microbiol	PROPN
admet-376	662	15	65	65	NUM
admet-376	662	16	(	(	PUNCT
admet-376	662	17	2011	2011	NUM
admet-376	662	18	)	)	PUNCT
admet-376	662	19	411	411	NUM
admet-376	662	20	-	-	SYM
admet-376	662	21	429	429	NUM
admet-376	662	22	.	.	PUNCT
admet-376	663	1	[	[	X
admet-376	663	2	178	178	NUM
admet-376	663	3	]	]	X
admet-376	663	4	y.	y.	NOUN
admet-376	663	5	field	field	PROPN
admet-376	663	6	,	,	PUNCT
admet-376	663	7	e.a	e.a	PROPN
admet-376	663	8	.	.	PROPN
admet-376	663	9	boyle	boyle	PROPN
admet-376	663	10	,	,	PUNCT
admet-376	663	11	n.	n.	PROPN
admet-376	663	12	telis	telis	PROPN
admet-376	663	13	,	,	PUNCT
admet-376	663	14	z.	z.	PROPN
admet-376	663	15	gao	gao	PROPN
admet-376	663	16	,	,	PUNCT
admet-376	663	17	k.j	k.j	PROPN
admet-376	663	18	.	.	PROPN
admet-376	663	19	gaulton	gaulton	PROPN
admet-376	663	20	,	,	PUNCT
admet-376	663	21	d.	d.	PROPN
admet-376	663	22	golan	golan	PROPN
admet-376	663	23	,	,	PUNCT
admet-376	663	24	l.	l.	PROPN
admet-376	663	25	yengo	yengo	PROPN
admet-376	663	26	,	,	PUNCT
admet-376	663	27	g.	g.	PROPN
admet-376	663	28	rocheleau	rocheleau	PROPN
admet-376	663	29	,	,	PUNCT
admet-376	663	30	p.	p.	NOUN
admet-376	663	31	froguel	froguel	NOUN
admet-376	663	32	,	,	PUNCT
admet-376	663	33	m.i	m.i	PROPN
admet-376	663	34	.	.	PROPN
admet-376	663	35	mccarthy	mccarthy	PROPN
admet-376	663	36	,	,	PUNCT
admet-376	663	37	j.k	j.k	PROPN
admet-376	663	38	.	.	PROPN
admet-376	663	39	pritchard	pritchard	PROPN
admet-376	663	40	.	.	PUNCT
admet-376	664	1	detection	detection	NOUN
admet-376	664	2	of	of	ADP
admet-376	664	3	human	human	ADJ
admet-376	664	4	adaptation	adaptation	NOUN
admet-376	664	5	during	during	ADP
admet-376	664	6	the	the	DET
admet-376	664	7	past	past	ADJ
admet-376	664	8	2000	2000	NUM
admet-376	664	9	years	year	NOUN
admet-376	664	10	,	,	PUNCT
admet-376	664	11	science	science	NOUN
admet-376	664	12	354	354	NUM
admet-376	664	13	(	(	PUNCT
admet-376	664	14	2016	2016	NUM
admet-376	664	15	)	)	PUNCT
admet-376	664	16	760	760	NUM
admet-376	664	17	-	-	SYM
admet-376	664	18	764	764	NUM
admet-376	664	19	.	.	PUNCT
admet-376	665	1	[	[	X
admet-376	665	2	179	179	NUM
admet-376	665	3	]	]	X
admet-376	665	4	s.	s.	PROPN
admet-376	665	5	jariyawat	jariyawat	PROPN
admet-376	665	6	,	,	PUNCT
admet-376	665	7	t.	t.	PROPN
admet-376	665	8	sekine	sekine	PROPN
admet-376	665	9	,	,	PUNCT
admet-376	665	10	m.	m.	NOUN
admet-376	665	11	takeda	takeda	PROPN
admet-376	665	12	,	,	PUNCT
admet-376	665	13	n.	n.	PROPN
admet-376	665	14	apiwattanakul	apiwattanakul	PROPN
admet-376	665	15	,	,	PUNCT
admet-376	665	16	y.	y.	PROPN
admet-376	665	17	kanai	kanai	PROPN
admet-376	665	18	,	,	PUNCT
admet-376	665	19	s.	s.	PROPN
admet-376	665	20	sophasan	sophasan	PROPN
admet-376	665	21	,	,	PUNCT
admet-376	665	22	h.	h.	PROPN
admet-376	665	23	endou	endou	NOUN
admet-376	665	24	.	.	PUNCT
admet-376	666	1	the	the	DET
admet-376	666	2	interaction	interaction	NOUN
admet-376	666	3	and	and	CCONJ
admet-376	666	4	transport	transport	NOUN
admet-376	666	5	of	of	ADP
admet-376	666	6	beta	beta	NOUN
admet-376	666	7	-	-	PUNCT
admet-376	666	8	lactam	lactam	NOUN
admet-376	666	9	antibiotics	antibiotic	NOUN
admet-376	666	10	with	with	ADP
admet-376	666	11	the	the	DET
admet-376	666	12	cloned	clone	VERB
admet-376	666	13	rat	rat	NOUN
admet-376	666	14	renal	renal	ADJ
admet-376	666	15	organic	organic	ADJ
admet-376	666	16	anion	anion	NOUN
admet-376	666	17	transporter	transporter	NOUN
admet-376	666	18	1	1	NUM
admet-376	666	19	,	,	PUNCT
admet-376	666	20	j	j	PROPN
admet-376	666	21	pharmacol	pharmacol	PROPN
admet-376	666	22	exp	exp	NOUN
admet-376	666	23	ther	ther	NOUN
admet-376	666	24	290	290	NUM
admet-376	666	25	(	(	PUNCT
admet-376	666	26	1999	1999	NUM
admet-376	666	27	)	)	PUNCT
admet-376	666	28	672	672	NUM
admet-376	666	29	-	-	SYM
admet-376	666	30	677	677	NUM
admet-376	666	31	.	.	PUNCT
admet-376	667	1	[	[	X
admet-376	667	2	180	180	NUM
admet-376	667	3	]	]	X
admet-376	667	4	a.l	a.l	PROPN
admet-376	667	5	.	.	PROPN
admet-376	667	6	vanwert	vanwert	PROPN
admet-376	667	7	,	,	PUNCT
admet-376	667	8	r.m	r.m	PROPN
admet-376	667	9	.	.	PROPN
admet-376	667	10	bailey	bailey	PROPN
admet-376	667	11	,	,	PUNCT
admet-376	667	12	d.h	d.h	PROPN
admet-376	667	13	.	.	PROPN
admet-376	667	14	sweet	sweet	ADJ
admet-376	667	15	.	.	PUNCT
admet-376	668	1	organic	organic	ADJ
admet-376	668	2	anion	anion	NOUN
admet-376	668	3	transporter	transporter	NOUN
admet-376	668	4	3	3	NUM
admet-376	668	5	(	(	PUNCT
admet-376	668	6	oat3	oat3	NOUN
admet-376	668	7	/	/	SYM
admet-376	668	8	slc22a8	slc22a8	NOUN
admet-376	668	9	)	)	PUNCT
admet-376	668	10	knockout	knockout	NOUN
admet-376	668	11	mice	mouse	NOUN
admet-376	668	12	exhibit	exhibit	VERB
admet-376	668	13	altered	alter	VERB
admet-376	668	14	clearance	clearance	NOUN
admet-376	668	15	and	and	CCONJ
admet-376	668	16	distribution	distribution	NOUN
admet-376	668	17	of	of	ADP
admet-376	668	18	penicillin	penicillin	NOUN
admet-376	668	19	g	g	PROPN
admet-376	668	20	,	,	PUNCT
admet-376	668	21	am	be	AUX
admet-376	668	22	j	j	PROPN
admet-376	668	23	physiol	physiol	PROPN
admet-376	668	24	renal	renal	PROPN
admet-376	668	25	physiol	physiol	PROPN
admet-376	668	26	293	293	NUM
admet-376	668	27	(	(	PUNCT
admet-376	668	28	2007	2007	NUM
admet-376	668	29	)	)	PUNCT
admet-376	668	30	f13321341	f13321341	NOUN
admet-376	668	31	.	.	PUNCT
admet-376	669	1	[	[	X
admet-376	669	2	181	181	NUM
admet-376	669	3	]	]	X
admet-376	669	4	s.	s.	PROPN
admet-376	669	5	khamdang	khamdang	PROPN
admet-376	669	6	,	,	PUNCT
admet-376	669	7	m.	m.	NOUN
admet-376	669	8	takeda	takeda	PROPN
admet-376	669	9	,	,	PUNCT
admet-376	669	10	e.	e.	PROPN
admet-376	669	11	babu	babu	PROPN
admet-376	669	12	,	,	PUNCT
admet-376	669	13	r.	r.	PROPN
admet-376	669	14	noshiro	noshiro	PROPN
admet-376	669	15	,	,	PUNCT
admet-376	669	16	m.l	m.l	PROPN
admet-376	669	17	.	.	PROPN
admet-376	669	18	onozato	onozato	PROPN
admet-376	669	19	,	,	PUNCT
admet-376	669	20	a.	a.	PROPN
admet-376	669	21	tojo	tojo	PROPN
admet-376	669	22	,	,	PUNCT
admet-376	669	23	a.	a.	NOUN
admet-376	669	24	enomoto	enomoto	NOUN
admet-376	669	25	,	,	PUNCT
admet-376	669	26	x.l	x.l	PROPN
admet-376	669	27	.	.	PROPN
admet-376	669	28	huang	huang	PROPN
admet-376	669	29	,	,	PUNCT
admet-376	669	30	s.	s.	PROPN
admet-376	669	31	narikawa	narikawa	PROPN
admet-376	669	32	,	,	PUNCT
admet-376	669	33	n.	n.	PROPN
admet-376	669	34	anzai	anzai	NOUN
admet-376	669	35	,	,	PUNCT
admet-376	669	36	p.	p.	NOUN
admet-376	669	37	piyachaturawat	piyachaturawat	PROPN
admet-376	669	38	,	,	PUNCT
admet-376	669	39	h.	h.	PROPN
admet-376	669	40	endou	endou	NOUN
admet-376	669	41	.	.	PUNCT
admet-376	670	1	interaction	interaction	NOUN
admet-376	670	2	of	of	ADP
admet-376	670	3	human	human	ADJ
admet-376	670	4	and	and	CCONJ
admet-376	670	5	rat	rat	NOUN
admet-376	670	6	organic	organic	ADJ
admet-376	670	7	anion	anion	NOUN
admet-376	670	8	transporter	transporter	NOUN
admet-376	670	9	2	2	NUM
admet-376	670	10	with	with	ADP
admet-376	670	11	various	various	ADJ
admet-376	670	12	cephalosporin	cephalosporin	NOUN
admet-376	670	13	antibiotics	antibiotic	NOUN
admet-376	670	14	,	,	PUNCT
admet-376	670	15	eur	eur	PROPN
admet-376	670	16	j	j	PROPN
admet-376	670	17	pharmacol	pharmacol	PROPN
admet-376	670	18	465	465	NUM
admet-376	670	19	(	(	PUNCT
admet-376	670	20	2003	2003	NUM
admet-376	670	21	)	)	PUNCT
admet-376	670	22	1	1	NUM
admet-376	670	23	-	-	SYM
admet-376	670	24	7	7	NUM
admet-376	670	25	.	.	PUNCT
admet-376	671	1	[	[	X
admet-376	671	2	182	182	NUM
admet-376	671	3	]	]	PUNCT
admet-376	671	4	h.	h.	PROPN
admet-376	671	5	ueo	ueo	PROPN
admet-376	671	6	,	,	PUNCT
admet-376	671	7	h.	h.	PROPN
admet-376	671	8	motohashi	motohashi	NOUN
admet-376	671	9	,	,	PUNCT
admet-376	671	10	t.	t.	PROPN
admet-376	671	11	katsura	katsura	PROPN
admet-376	671	12	,	,	PUNCT
admet-376	671	13	k.	k.	PROPN
admet-376	671	14	inui	inui	PROPN
admet-376	671	15	.	.	PUNCT
admet-376	672	1	human	human	ADJ
admet-376	672	2	organic	organic	ADJ
admet-376	672	3	anion	anion	NOUN
admet-376	672	4	transporter	transporter	NOUN
admet-376	672	5	hoat3	hoat3	NOUN
admet-376	672	6	is	be	AUX
admet-376	672	7	a	a	DET
admet-376	672	8	potent	potent	ADJ
admet-376	672	9	transporter	transporter	NOUN
admet-376	672	10	of	of	ADP
admet-376	672	11	cephalosporin	cephalosporin	NOUN
admet-376	672	12	antibiotics	antibiotic	NOUN
admet-376	672	13	,	,	PUNCT
admet-376	672	14	in	in	ADP
admet-376	672	15	comparison	comparison	NOUN
admet-376	672	16	with	with	ADP
admet-376	672	17	hoat1	hoat1	NOUN
admet-376	672	18	,	,	PUNCT
admet-376	672	19	biochem	biochem	PROPN
admet-376	672	20	pharmacol	pharmacol	VERB
admet-376	672	21	70	70	NUM
admet-376	672	22	(	(	PUNCT
admet-376	672	23	2005	2005	NUM
admet-376	672	24	)	)	PUNCT
admet-376	672	25	1104	1104	NUM
admet-376	672	26	-	-	SYM
admet-376	672	27	1113	1113	NUM
admet-376	672	28	.	.	PUNCT
admet-376	673	1	[	[	X
admet-376	673	2	183	183	NUM
admet-376	673	3	]	]	PUNCT
admet-376	673	4	e.	e.	PROPN
admet-376	673	5	babu	babu	PROPN
admet-376	673	6	,	,	PUNCT
admet-376	673	7	m.	m.	NOUN
admet-376	673	8	takeda	takeda	PROPN
admet-376	673	9	,	,	PUNCT
admet-376	673	10	s.	s.	PROPN
admet-376	673	11	narikawa	narikawa	PROPN
admet-376	673	12	,	,	PUNCT
admet-376	673	13	y.	y.	PROPN
admet-376	673	14	kobayashi	kobayashi	PROPN
admet-376	673	15	,	,	PUNCT
admet-376	673	16	t.	t.	PROPN
admet-376	673	17	yamamoto	yamamoto	PROPN
admet-376	673	18	,	,	PUNCT
admet-376	673	19	s.h	s.h	PROPN
admet-376	673	20	.	.	PROPN
admet-376	673	21	cha	cha	PROPN
admet-376	673	22	,	,	PUNCT
admet-376	673	23	t.	t.	PROPN
admet-376	673	24	sekine	sekine	PROPN
admet-376	673	25	,	,	PUNCT
admet-376	673	26	d.	d.	PROPN
admet-376	673	27	sakthisekaran	sakthisekaran	PROPN
admet-376	673	28	,	,	PUNCT
admet-376	673	29	h.	h.	PROPN
admet-376	673	30	endou	endou	NOUN
admet-376	673	31	.	.	PUNCT
admet-376	674	1	human	human	ADJ
admet-376	674	2	organic	organic	ADJ
admet-376	674	3	anion	anion	NOUN
admet-376	674	4	transporters	transporter	NOUN
admet-376	674	5	mediate	mediate	VERB
admet-376	674	6	the	the	DET
admet-376	674	7	transport	transport	NOUN
admet-376	674	8	of	of	ADP
admet-376	674	9	tetracycline	tetracycline	NOUN
admet-376	674	10	,	,	PUNCT
admet-376	674	11	jpn	jpn	PROPN
admet-376	674	12	j	j	PROPN
admet-376	674	13	pharmacol	pharmacol	PROPN
admet-376	674	14	88	88	NUM
admet-376	674	15	(	(	PUNCT
admet-376	674	16	2002	2002	NUM
admet-376	674	17	)	)	PUNCT
admet-376	674	18	69	69	NUM
admet-376	674	19	-	-	SYM
admet-376	674	20	76	76	NUM
admet-376	674	21	.	.	PUNCT
admet-376	675	1	[	[	X
admet-376	675	2	184	184	NUM
admet-376	675	3	]	]	PUNCT
admet-376	675	4	m.	m.	NOUN
admet-376	675	5	sugawara	sugawara	NOUN
admet-376	675	6	,	,	PUNCT
admet-376	675	7	t.	t.	PROPN
admet-376	675	8	mochizuki	mochizuki	PROPN
admet-376	675	9	,	,	PUNCT
admet-376	675	10	y.	y.	PROPN
admet-376	675	11	takekuma	takekuma	PROPN
admet-376	675	12	,	,	PUNCT
admet-376	675	13	k.	k.	PROPN
admet-376	675	14	miyazaki	miyazaki	PROPN
admet-376	675	15	.	.	PUNCT
admet-376	676	1	structure	structure	NOUN
admet-376	676	2	-	-	PUNCT
admet-376	676	3	affinity	affinity	NOUN
admet-376	676	4	relationship	relationship	NOUN
admet-376	676	5	in	in	ADP
admet-376	676	6	the	the	DET
admet-376	676	7	interactions	interaction	NOUN
admet-376	676	8	of	of	ADP
admet-376	676	9	human	human	ADJ
admet-376	676	10	organic	organic	ADJ
admet-376	676	11	anion	anion	NOUN
admet-376	676	12	transporter	transporter	NOUN
admet-376	676	13	1	1	NUM
admet-376	676	14	with	with	ADP
admet-376	676	15	caffeine	caffeine	NOUN
admet-376	676	16	,	,	PUNCT
admet-376	676	17	theophylline	theophylline	NOUN
admet-376	676	18	,	,	PUNCT
admet-376	676	19	theobromine	theobromine	NOUN
admet-376	676	20	and	and	CCONJ
admet-376	676	21	their	their	PRON
admet-376	676	22	metabolites	metabolite	NOUN
admet-376	676	23	,	,	PUNCT
admet-376	676	24	biochim	biochim	NOUN
admet-376	676	25	biophys	biophy	NOUN
admet-376	676	26	acta	acta	PROPN
admet-376	676	27	1714	1714	NUM
admet-376	676	28	(	(	PUNCT
admet-376	676	29	2005	2005	NUM
admet-376	676	30	)	)	PUNCT
admet-376	676	31	85	85	NUM
admet-376	676	32	-	-	SYM
admet-376	676	33	92	92	NUM
admet-376	676	34	.	.	PUNCT
admet-376	677	1	[	[	X
admet-376	677	2	185	185	NUM
admet-376	677	3	]	]	PUNCT
admet-376	677	4	t.	t.	NOUN
admet-376	677	5	mikkaichi	mikkaichi	PROPN
admet-376	677	6	,	,	PUNCT
admet-376	677	7	t.	t.	PROPN
admet-376	677	8	suzuki	suzuki	PROPN
admet-376	677	9	,	,	PUNCT
admet-376	677	10	t.	t.	PROPN
admet-376	677	11	onogawa	onogawa	PROPN
admet-376	677	12	,	,	PUNCT
admet-376	677	13	m.	m.	NOUN
admet-376	677	14	tanemoto	tanemoto	PROPN
admet-376	677	15	,	,	PUNCT
admet-376	677	16	h.	h.	PROPN
admet-376	677	17	mizutamari	mizutamari	PROPN
admet-376	677	18	,	,	PUNCT
admet-376	677	19	m.	m.	NOUN
admet-376	677	20	okada	okada	PROPN
admet-376	677	21	,	,	PUNCT
admet-376	677	22	t.	t.	PROPN
admet-376	677	23	chaki	chaki	PROPN
admet-376	677	24	,	,	PUNCT
admet-376	677	25	s.	s.	PROPN
admet-376	677	26	masuda	masuda	PROPN
admet-376	677	27	,	,	PUNCT
admet-376	677	28	t.	t.	NOUN
admet-376	677	29	tokui	tokui	PROPN
admet-376	677	30	,	,	PUNCT
admet-376	677	31	n.	n.	PROPN
admet-376	677	32	eto	eto	PROPN
admet-376	677	33	,	,	PUNCT
admet-376	677	34	m.	m.	PROPN
admet-376	677	35	abe	abe	PROPN
admet-376	677	36	,	,	PUNCT
admet-376	677	37	f.	f.	PROPN
admet-376	677	38	satoh	satoh	PROPN
admet-376	677	39	,	,	PUNCT
admet-376	677	40	m.	m.	NOUN
admet-376	677	41	unno	unno	NOUN
admet-376	677	42	,	,	PUNCT
admet-376	677	43	t.	t.	PROPN
admet-376	677	44	hishinuma	hishinuma	PROPN
admet-376	677	45	,	,	PUNCT
admet-376	677	46	k.	k.	PROPN
admet-376	677	47	inui	inui	PROPN
admet-376	677	48	,	,	PUNCT
admet-376	677	49	s.	s.	PROPN
admet-376	677	50	ito	ito	PROPN
admet-376	677	51	,	,	PUNCT
admet-376	677	52	j.	j.	PROPN
admet-376	677	53	goto	goto	PROPN
admet-376	677	54	,	,	PUNCT
admet-376	677	55	t.	t.	PROPN
admet-376	677	56	abe	abe	PROPN
admet-376	677	57	.	.	PUNCT
admet-376	678	1	isolation	isolation	NOUN
admet-376	678	2	and	and	CCONJ
admet-376	678	3	characterization	characterization	NOUN
admet-376	678	4	of	of	ADP
admet-376	678	5	a	a	DET
admet-376	678	6	digoxin	digoxin	NOUN
admet-376	678	7	transporter	transporter	NOUN
admet-376	678	8	and	and	CCONJ
admet-376	678	9	its	its	PRON
admet-376	678	10	rat	rat	NOUN
admet-376	678	11	homologue	homologue	NOUN
admet-376	678	12	expressed	express	VERB
admet-376	678	13	in	in	ADP
admet-376	678	14	the	the	DET
admet-376	678	15	kidney	kidney	NOUN
admet-376	678	16	,	,	PUNCT
admet-376	678	17	proc	proc	PROPN
admet-376	678	18	natl	natl	PROPN
admet-376	678	19	acad	acad	PROPN
admet-376	678	20	sci	sci	PROPN
admet-376	678	21	u	u	PROPN
admet-376	678	22	s	s	PROPN
admet-376	678	23	a	a	DET
admet-376	678	24	101	101	NUM
admet-376	678	25	(	(	PUNCT
admet-376	678	26	2004	2004	NUM
admet-376	678	27	)	)	PUNCT
admet-376	678	28	3569	3569	NUM
admet-376	678	29	-	-	SYM
admet-376	678	30	3574	3574	NUM
admet-376	678	31	.	.	PUNCT
admet-376	679	1	[	[	X
admet-376	679	2	186	186	NUM
admet-376	679	3	]	]	X
admet-376	679	4	a.t	a.t	PROPN
admet-376	679	5	.	.	PROPN
admet-376	679	6	nies	nies	PROPN
admet-376	679	7	,	,	PUNCT
admet-376	679	8	e.	e.	PROPN
admet-376	679	9	herrmann	herrmann	PROPN
admet-376	679	10	,	,	PUNCT
admet-376	679	11	m.	m.	NOUN
admet-376	679	12	brom	brom	PROPN
admet-376	679	13	,	,	PUNCT
admet-376	679	14	d.	d.	PROPN
admet-376	679	15	keppler	keppler	PROPN
admet-376	679	16	.	.	PUNCT
admet-376	680	1	vectorial	vectorial	ADJ
admet-376	680	2	transport	transport	NOUN
admet-376	680	3	of	of	ADP
admet-376	680	4	the	the	DET
admet-376	680	5	plant	plant	NOUN
admet-376	680	6	alkaloid	alkaloid	PROPN
admet-376	680	7	berberine	berberine	NOUN
admet-376	680	8	by	by	ADP
admet-376	680	9	double	double	ADJ
admet-376	680	10	-	-	PUNCT
admet-376	680	11	transfected	transfecte	VERB
admet-376	680	12	cells	cell	NOUN
admet-376	680	13	expressing	express	VERB
admet-376	680	14	the	the	DET
admet-376	680	15	human	human	ADJ
admet-376	680	16	organic	organic	ADJ
admet-376	680	17	cation	cation	NOUN
admet-376	680	18	transporter	transporter	NOUN
admet-376	680	19	1	1	NUM
admet-376	680	20	(	(	PUNCT
admet-376	680	21	oct1	oct1	NOUN
admet-376	680	22	,	,	PUNCT
admet-376	680	23	slc22a1	slc22a1	PROPN
admet-376	680	24	)	)	PUNCT
admet-376	680	25	and	and	CCONJ
admet-376	680	26	the	the	DET
admet-376	680	27	admet	admet	PROPN
admet-376	680	28	&	&	CCONJ
admet-376	680	29	dmpk	dmpk	PROPN
admet-376	680	30	5(2	5(2	NUM
admet-376	680	31	)	)	PUNCT
admet-376	680	32	(	(	PUNCT
admet-376	680	33	2017	2017	NUM
admet-376	680	34	)	)	PUNCT
admet-376	680	35	85	85	NUM
admet-376	680	36	-	-	SYM
admet-376	680	37	125	125	NUM
admet-376	680	38	exogenous	exogenous	ADJ
admet-376	680	39	natural	natural	ADJ
admet-376	680	40	products	product	NOUN
admet-376	680	41	as	as	ADP
admet-376	680	42	‘	'	PUNCT
admet-376	680	43	natural	natural	ADJ
admet-376	680	44	’	'	PUNCT
admet-376	680	45	drug	drug	NOUN
admet-376	680	46	transporter	transporter	NOUN
admet-376	680	47	substrates	substrate	VERB
admet-376	680	48	doi	doi	NOUN
admet-376	680	49	:	:	PUNCT
admet-376	680	50	10.5599	10.5599	NUM
admet-376	680	51	/	/	SYM
admet-376	680	52	admet.5.2.376	admet.5.2.376	PROPN
admet-376	680	53	123	123	NUM
admet-376	680	54	efflux	efflux	NOUN
admet-376	680	55	pump	pump	NOUN
admet-376	680	56	mdr1	mdr1	PROPN
admet-376	680	57	p	p	NOUN
admet-376	680	58	-	-	PUNCT
admet-376	680	59	glycoprotein	glycoprotein	NOUN
admet-376	680	60	(	(	PUNCT
admet-376	680	61	abcb1	abcb1	NOUN
admet-376	680	62	)	)	PUNCT
admet-376	680	63	,	,	PUNCT
admet-376	680	64	naunyn	naunyn	PROPN
admet-376	680	65	schmiedebergs	schmiedeberg	VERB
admet-376	680	66	arch	arch	PROPN
admet-376	680	67	pharmacol	pharmacol	PROPN
admet-376	680	68	376	376	NUM
admet-376	680	69	(	(	PUNCT
admet-376	680	70	2008	2008	NUM
admet-376	680	71	)	)	PUNCT
admet-376	680	72	449461	449461	NUM
admet-376	680	73	.	.	PUNCT
admet-376	681	1	[	[	X
admet-376	681	2	187	187	NUM
admet-376	681	3	]	]	PUNCT
admet-376	681	4	l.	l.	PROPN
admet-376	681	5	li	li	PROPN
admet-376	681	6	,	,	PUNCT
admet-376	681	7	s.	s.	PROPN
admet-376	681	8	sun	sun	PROPN
admet-376	681	9	,	,	PUNCT
admet-376	681	10	y.	y.	PROPN
admet-376	681	11	weng	weng	PROPN
admet-376	681	12	,	,	PUNCT
admet-376	681	13	f.	f.	PROPN
admet-376	681	14	song	song	PROPN
admet-376	681	15	,	,	PUNCT
admet-376	681	16	s.	s.	PROPN
admet-376	681	17	zhou	zhou	PROPN
admet-376	681	18	,	,	PUNCT
admet-376	681	19	m.	m.	PROPN
admet-376	681	20	bai	bai	PROPN
admet-376	681	21	,	,	PUNCT
admet-376	681	22	h.	h.	PROPN
admet-376	681	23	zhou	zhou	PROPN
admet-376	681	24	,	,	PUNCT
admet-376	681	25	s.	s.	PROPN
admet-376	681	26	zeng	zeng	PROPN
admet-376	681	27	,	,	PUNCT
admet-376	681	28	h.	h.	PROPN
admet-376	681	29	jiang	jiang	PROPN
admet-376	681	30	.	.	PUNCT
admet-376	682	1	interaction	interaction	NOUN
admet-376	682	2	of	of	ADP
admet-376	682	3	six	six	NUM
admet-376	682	4	protoberberine	protoberberine	NOUN
admet-376	682	5	alkaloids	alkaloid	NOUN
admet-376	682	6	with	with	ADP
admet-376	682	7	human	human	ADJ
admet-376	682	8	organic	organic	ADJ
admet-376	682	9	cation	cation	NOUN
admet-376	682	10	transporters	transporter	NOUN
admet-376	682	11	1	1	NUM
admet-376	682	12	,	,	PUNCT
admet-376	682	13	2	2	NUM
admet-376	682	14	and	and	CCONJ
admet-376	682	15	3	3	NUM
admet-376	682	16	,	,	PUNCT
admet-376	682	17	xenobiotica	xenobiotica	PROPN
admet-376	682	18	46	46	NUM
admet-376	682	19	(	(	PUNCT
admet-376	682	20	2016	2016	NUM
admet-376	682	21	)	)	PUNCT
admet-376	682	22	175	175	NUM
admet-376	682	23	-	-	SYM
admet-376	682	24	183	183	NUM
admet-376	682	25	.	.	PUNCT
admet-376	683	1	[	[	X
admet-376	683	2	188	188	NUM
admet-376	683	3	]	]	X
admet-376	683	4	m.v	m.v	PROPN
admet-376	683	5	.	.	PROPN
admet-376	683	6	tzvetkov	tzvetkov	PROPN
admet-376	683	7	,	,	PUNCT
admet-376	683	8	j.n.d	j.n.d	NOUN
admet-376	683	9	.	.	PUNCT
admet-376	684	1	pereira	pereira	PROPN
admet-376	684	2	,	,	PUNCT
admet-376	684	3	i.	i.	PROPN
admet-376	684	4	meineke	meineke	PROPN
admet-376	684	5	,	,	PUNCT
admet-376	684	6	a.r	a.r	PROPN
admet-376	684	7	.	.	PROPN
admet-376	684	8	saadatmand	saadatmand	PROPN
admet-376	684	9	,	,	PUNCT
admet-376	684	10	j.c	j.c	PROPN
admet-376	684	11	.	.	PROPN
admet-376	684	12	stingl	stingl	PROPN
admet-376	684	13	,	,	PUNCT
admet-376	684	14	j.	j.	PROPN
admet-376	684	15	brockmöller	brockmöller	PROPN
admet-376	684	16	.	.	PUNCT
admet-376	685	1	morphine	morphine	PROPN
admet-376	685	2	is	be	AUX
admet-376	685	3	a	a	DET
admet-376	685	4	substrate	substrate	NOUN
admet-376	685	5	of	of	ADP
admet-376	685	6	the	the	DET
admet-376	685	7	organic	organic	ADJ
admet-376	685	8	cation	cation	NOUN
admet-376	685	9	transporter	transporter	NOUN
admet-376	685	10	oct1	oct1	NOUN
admet-376	685	11	and	and	CCONJ
admet-376	685	12	polymorphisms	polymorphism	NOUN
admet-376	685	13	in	in	ADP
admet-376	685	14	oct1	oct1	NOUN
admet-376	685	15	gene	gene	NOUN
admet-376	685	16	affect	affect	VERB
admet-376	685	17	morphine	morphine	NOUN
admet-376	685	18	pharmacokinetics	pharmacokinetic	NOUN
admet-376	685	19	after	after	ADP
admet-376	685	20	codeine	codeine	PROPN
admet-376	685	21	administration	administration	PROPN
admet-376	685	22	,	,	PUNCT
admet-376	685	23	biochem	biochem	PROPN
admet-376	685	24	pharmacol	pharmacol	VERB
admet-376	685	25	86	86	NUM
admet-376	685	26	(	(	PUNCT
admet-376	685	27	2013	2013	NUM
admet-376	685	28	)	)	PUNCT
admet-376	685	29	666	666	NUM
admet-376	685	30	-	-	SYM
admet-376	685	31	678	678	NUM
admet-376	685	32	.	.	PUNCT
admet-376	686	1	[	[	X
admet-376	686	2	189	189	NUM
admet-376	686	3	]	]	X
admet-376	686	4	y.	y.	PROPN
admet-376	686	5	kobayashi	kobayashi	PROPN
admet-376	686	6	,	,	PUNCT
admet-376	686	7	r.	r.	PROPN
admet-376	686	8	sakai	sakai	PROPN
admet-376	686	9	,	,	PUNCT
admet-376	686	10	n.	n.	PROPN
admet-376	686	11	ohshiro	ohshiro	NOUN
admet-376	686	12	,	,	PUNCT
admet-376	686	13	m.	m.	NOUN
admet-376	686	14	ohbayashi	ohbayashi	PROPN
admet-376	686	15	,	,	PUNCT
admet-376	686	16	n.	n.	PROPN
admet-376	686	17	kohyama	kohyama	PROPN
admet-376	686	18	,	,	PUNCT
admet-376	686	19	t.	t.	PROPN
admet-376	686	20	yamamoto	yamamoto	PROPN
admet-376	686	21	.	.	PUNCT
admet-376	687	1	possible	possible	ADJ
admet-376	687	2	involvement	involvement	NOUN
admet-376	687	3	of	of	ADP
admet-376	687	4	organic	organic	ADJ
admet-376	687	5	anion	anion	NOUN
admet-376	687	6	transporter	transporter	NOUN
admet-376	687	7	2	2	NUM
admet-376	687	8	on	on	ADP
admet-376	687	9	the	the	DET
admet-376	687	10	interaction	interaction	NOUN
admet-376	687	11	of	of	ADP
admet-376	687	12	theophylline	theophylline	NOUN
admet-376	687	13	with	with	ADP
admet-376	687	14	erythromycin	erythromycin	NOUN
admet-376	687	15	in	in	ADP
admet-376	687	16	the	the	DET
admet-376	687	17	human	human	ADJ
admet-376	687	18	liver	liver	NOUN
admet-376	687	19	,	,	PUNCT
admet-376	687	20	drug	drug	NOUN
admet-376	687	21	metab	metab	NOUN
admet-376	687	22	dispos	dispos	PROPN
admet-376	687	23	33	33	NUM
admet-376	687	24	(	(	PUNCT
admet-376	687	25	2005	2005	NUM
admet-376	687	26	)	)	PUNCT
admet-376	687	27	619	619	NUM
admet-376	687	28	-	-	SYM
admet-376	687	29	622	622	NUM
admet-376	687	30	.	.	PUNCT
admet-376	688	1	[	[	X
admet-376	688	2	190	190	NUM
admet-376	688	3	]	]	PUNCT
admet-376	688	4	m.	m.	NOUN
admet-376	688	5	li	li	PROPN
admet-376	688	6	,	,	PUNCT
admet-376	688	7	g.d	g.d	PROPN
admet-376	688	8	.	.	PROPN
admet-376	688	9	anderson	anderson	PROPN
admet-376	688	10	,	,	PUNCT
admet-376	688	11	b.r	b.r	PROPN
admet-376	688	12	.	.	PROPN
admet-376	688	13	phillips	phillips	PROPN
admet-376	688	14	,	,	PUNCT
admet-376	688	15	w.	w.	PROPN
admet-376	688	16	kong	kong	PROPN
admet-376	688	17	,	,	PUNCT
admet-376	688	18	d.d	d.d	PROPN
admet-376	688	19	.	.	PROPN
admet-376	688	20	shen	shen	PROPN
admet-376	688	21	,	,	PUNCT
admet-376	688	22	j.	j.	PROPN
admet-376	688	23	wang	wang	PROPN
admet-376	688	24	.	.	PUNCT
admet-376	688	25	interactions	interaction	NOUN
admet-376	688	26	of	of	ADP
admet-376	688	27	amoxicillin	amoxicillin	NOUN
admet-376	688	28	and	and	CCONJ
admet-376	688	29	cefaclor	cefaclor	NOUN
admet-376	688	30	with	with	ADP
admet-376	688	31	human	human	ADJ
admet-376	688	32	renal	renal	ADJ
admet-376	688	33	organic	organic	ADJ
admet-376	688	34	anion	anion	NOUN
admet-376	688	35	and	and	CCONJ
admet-376	688	36	peptide	peptide	NOUN
admet-376	688	37	transporters	transporter	NOUN
admet-376	688	38	,	,	PUNCT
admet-376	688	39	drug	drug	NOUN
admet-376	688	40	metab	metab	NOUN
admet-376	688	41	dispos	dispos	PROPN
admet-376	688	42	34	34	NUM
admet-376	688	43	(	(	PUNCT
admet-376	688	44	2006	2006	NUM
admet-376	688	45	)	)	PUNCT
admet-376	688	46	547555	547555	NUM
admet-376	688	47	.	.	PUNCT
admet-376	689	1	[	[	X
admet-376	689	2	191	191	NUM
admet-376	689	3	]	]	PUNCT
admet-376	689	4	m.	m.	NOUN
admet-376	689	5	sala	sala	PROPN
admet-376	689	6	-	-	PUNCT
admet-376	689	7	rabanal	rabanal	ADJ
admet-376	689	8	,	,	PUNCT
admet-376	689	9	d.d	d.d	PROPN
admet-376	689	10	.	.	PROPN
admet-376	689	11	loo	loo	PROPN
admet-376	689	12	,	,	PUNCT
admet-376	689	13	b.a	b.a	PROPN
admet-376	689	14	.	.	PROPN
admet-376	689	15	hirayama	hirayama	PROPN
admet-376	689	16	,	,	PUNCT
admet-376	689	17	e.	e.	PROPN
admet-376	689	18	turk	turk	PROPN
admet-376	689	19	,	,	PUNCT
admet-376	689	20	e.m	e.m	PROPN
admet-376	689	21	.	.	PROPN
admet-376	689	22	wright	wright	PROPN
admet-376	689	23	.	.	PUNCT
admet-376	690	1	molecular	molecular	ADJ
admet-376	690	2	interactions	interaction	NOUN
admet-376	690	3	between	between	ADP
admet-376	690	4	dipeptides	dipeptide	NOUN
admet-376	690	5	,	,	PUNCT
admet-376	690	6	drugs	drug	NOUN
admet-376	690	7	and	and	CCONJ
admet-376	690	8	the	the	DET
admet-376	690	9	human	human	ADJ
admet-376	690	10	intestinal	intestinal	ADJ
admet-376	690	11	h+	h+	PUNCT
admet-376	690	12	-oligopeptide	-oligopeptide	ADJ
admet-376	690	13	cotransporter	cotransporter	NOUN
admet-376	690	14	hpept1	hpept1	NOUN
admet-376	690	15	,	,	PUNCT
admet-376	690	16	j	j	PROPN
admet-376	690	17	physiol	physiol	PROPN
admet-376	690	18	574	574	NUM
admet-376	690	19	(	(	PUNCT
admet-376	690	20	2006	2006	NUM
admet-376	690	21	)	)	PUNCT
admet-376	690	22	149	149	NUM
admet-376	690	23	-	-	SYM
admet-376	690	24	166	166	NUM
admet-376	690	25	.	.	PUNCT
admet-376	691	1	[	[	X
admet-376	691	2	192	192	NUM
admet-376	691	3	]	]	PUNCT
admet-376	691	4	s.	s.	PROPN
admet-376	691	5	bröer	bröer	PROPN
admet-376	691	6	,	,	PUNCT
admet-376	691	7	u.	u.	PROPN
admet-376	691	8	gether	gether	PROPN
admet-376	691	9	.	.	PUNCT
admet-376	692	1	the	the	DET
admet-376	692	2	solute	solute	ADJ
admet-376	692	3	carrier	carrier	NOUN
admet-376	692	4	6	6	NUM
admet-376	692	5	family	family	NOUN
admet-376	692	6	of	of	ADP
admet-376	692	7	transporters	transporter	NOUN
admet-376	692	8	,	,	PUNCT
admet-376	692	9	br	br	PROPN
admet-376	692	10	j	j	PROPN
admet-376	692	11	pharmacol	pharmacol	PROPN
admet-376	692	12	167	167	NUM
admet-376	692	13	(	(	PUNCT
admet-376	692	14	2012	2012	NUM
admet-376	692	15	)	)	PUNCT
admet-376	692	16	256	256	NUM
admet-376	692	17	-	-	SYM
admet-376	692	18	278	278	NUM
admet-376	692	19	.	.	PUNCT
admet-376	693	1	[	[	X
admet-376	693	2	193	193	NUM
admet-376	693	3	]	]	X
admet-376	693	4	d.m	d.m	PROPN
admet-376	693	5	.	.	PROPN
admet-376	693	6	raffel	raffel	PROPN
admet-376	693	7	,	,	PUNCT
admet-376	693	8	w.	w.	PROPN
admet-376	693	9	chen	chen	PROPN
admet-376	693	10	,	,	PUNCT
admet-376	693	11	y.w	y.w	PROPN
admet-376	693	12	.	.	PROPN
admet-376	693	13	jung	jung	PROPN
admet-376	693	14	,	,	PUNCT
admet-376	693	15	k.s	k.s	PROPN
admet-376	693	16	.	.	PROPN
admet-376	693	17	jang	jang	PROPN
admet-376	693	18	,	,	PUNCT
admet-376	693	19	g.	g.	PROPN
admet-376	693	20	gu	gu	PROPN
admet-376	693	21	,	,	PUNCT
admet-376	693	22	n.v	n.v	PROPN
admet-376	693	23	.	.	PUNCT
admet-376	693	24	cozzi	cozzi	PROPN
admet-376	693	25	.	.	PUNCT
admet-376	694	1	radiotracers	radiotracer	NOUN
admet-376	694	2	for	for	ADP
admet-376	694	3	cardiac	cardiac	ADJ
admet-376	694	4	sympathetic	sympathetic	ADJ
admet-376	694	5	innervation	innervation	NOUN
admet-376	694	6	:	:	PUNCT
admet-376	694	7	transport	transport	NOUN
admet-376	694	8	kinetics	kinetic	NOUN
admet-376	694	9	and	and	CCONJ
admet-376	694	10	binding	bind	VERB
admet-376	694	11	affinities	affinity	NOUN
admet-376	694	12	for	for	ADP
admet-376	694	13	the	the	DET
admet-376	694	14	human	human	ADJ
admet-376	694	15	norepinephrine	norepinephrine	NOUN
admet-376	694	16	transporter	transporter	NOUN
admet-376	694	17	,	,	PUNCT
admet-376	694	18	nucl	nucl	NOUN
admet-376	694	19	med	med	ADJ
admet-376	694	20	biol	biol	NOUN
admet-376	694	21	40	40	NUM
admet-376	694	22	(	(	PUNCT
admet-376	694	23	2013	2013	NUM
admet-376	694	24	)	)	PUNCT
admet-376	694	25	331	331	NUM
admet-376	694	26	-	-	SYM
admet-376	694	27	337	337	NUM
admet-376	694	28	.	.	PUNCT
admet-376	695	1	[	[	X
admet-376	695	2	194	194	NUM
admet-376	695	3	]	]	PUNCT
admet-376	695	4	v.	v.	X
admet-376	695	5	voigt	voigt	PROPN
admet-376	695	6	,	,	PUNCT
admet-376	695	7	l.	l.	PROPN
admet-376	695	8	laug	laug	PROPN
admet-376	695	9	,	,	PUNCT
admet-376	695	10	k.	k.	PROPN
admet-376	695	11	zebisch	zebisch	PROPN
admet-376	695	12	,	,	PUNCT
admet-376	695	13	i.	i.	PROPN
admet-376	695	14	thondorf	thondorf	PROPN
admet-376	695	15	,	,	PUNCT
admet-376	695	16	f.	f.	PROPN
admet-376	695	17	markwardt	markwardt	PROPN
admet-376	695	18	,	,	PUNCT
admet-376	695	19	m.	m.	NOUN
admet-376	695	20	brandsch	brandsch	PROPN
admet-376	695	21	.	.	PUNCT
admet-376	696	1	transport	transport	NOUN
admet-376	696	2	of	of	ADP
admet-376	696	3	the	the	DET
admet-376	696	4	areca	areca	PROPN
admet-376	696	5	nut	nut	PROPN
admet-376	696	6	alkaloid	alkaloid	PROPN
admet-376	696	7	arecaidine	arecaidine	NOUN
admet-376	696	8	by	by	ADP
admet-376	696	9	the	the	DET
admet-376	696	10	human	human	ADJ
admet-376	696	11	proton	proton	NOUN
admet-376	696	12	-	-	PUNCT
admet-376	696	13	coupled	couple	VERB
admet-376	696	14	amino	amino	NOUN
admet-376	696	15	acid	acid	NOUN
admet-376	696	16	transporter	transporter	NOUN
admet-376	696	17	1	1	NUM
admet-376	696	18	(	(	PUNCT
admet-376	696	19	hpat1	hpat1	NOUN
admet-376	696	20	)	)	PUNCT
admet-376	696	21	,	,	PUNCT
admet-376	696	22	j	j	PROPN
admet-376	696	23	pharm	pharm	PROPN
admet-376	696	24	pharmacol	pharmacol	PROPN
admet-376	696	25	65	65	NUM
admet-376	696	26	(	(	PUNCT
admet-376	696	27	2013	2013	NUM
admet-376	696	28	)	)	PUNCT
admet-376	696	29	582	582	NUM
admet-376	696	30	-	-	SYM
admet-376	696	31	590	590	NUM
admet-376	696	32	.	.	PUNCT
admet-376	697	1	[	[	X
admet-376	697	2	195	195	NUM
admet-376	697	3	]	]	X
admet-376	697	4	h.	h.	PROPN
admet-376	697	5	tsukaguchi	tsukaguchi	PROPN
admet-376	697	6	,	,	PUNCT
admet-376	697	7	t.	t.	PROPN
admet-376	697	8	tokui	tokui	PROPN
admet-376	697	9	,	,	PUNCT
admet-376	697	10	b.	b.	PROPN
admet-376	697	11	mackenzie	mackenzie	PROPN
admet-376	697	12	,	,	PUNCT
admet-376	697	13	u.v	u.v	PROPN
admet-376	697	14	.	.	PROPN
admet-376	697	15	berger	berger	PROPN
admet-376	697	16	,	,	PUNCT
admet-376	697	17	x.z	x.z	PROPN
admet-376	697	18	.	.	PROPN
admet-376	697	19	chen	chen	PROPN
admet-376	697	20	,	,	PUNCT
admet-376	697	21	y.	y.	PROPN
admet-376	697	22	wang	wang	PROPN
admet-376	697	23	,	,	PUNCT
admet-376	697	24	r.f	r.f	PROPN
admet-376	697	25	.	.	PROPN
admet-376	697	26	brubaker	brubaker	PROPN
admet-376	697	27	,	,	PUNCT
admet-376	697	28	m.a	m.a	PROPN
admet-376	697	29	.	.	PROPN
admet-376	697	30	hediger	hediger	PROPN
admet-376	697	31	.	.	PUNCT
admet-376	698	1	a	a	DET
admet-376	698	2	family	family	NOUN
admet-376	698	3	of	of	ADP
admet-376	698	4	mammalian	mammalian	ADJ
admet-376	698	5	na+-dependent	na+-dependent	PROPN
admet-376	698	6	l	l	ADJ
admet-376	698	7	-	-	ADJ
admet-376	698	8	ascorbic	ascorbic	ADJ
admet-376	698	9	acid	acid	NOUN
admet-376	698	10	transporters	transporter	NOUN
admet-376	698	11	,	,	PUNCT
admet-376	698	12	nature	nature	NOUN
admet-376	698	13	399	399	NUM
admet-376	698	14	(	(	PUNCT
admet-376	698	15	1999	1999	NUM
admet-376	698	16	)	)	PUNCT
admet-376	698	17	70	70	NUM
admet-376	698	18	-	-	SYM
admet-376	698	19	75	75	NUM
admet-376	698	20	.	.	PUNCT
admet-376	699	1	[	[	X
admet-376	699	2	196	196	NUM
admet-376	699	3	]	]	X
admet-376	699	4	j.m	j.m	PROPN
admet-376	699	5	.	.	PROPN
admet-376	699	6	may	may	AUX
admet-376	699	7	.	.	PUNCT
admet-376	700	1	the	the	DET
admet-376	700	2	slc23	slc23	PROPN
admet-376	700	3	family	family	NOUN
admet-376	700	4	of	of	ADP
admet-376	700	5	ascorbate	ascorbate	NOUN
admet-376	700	6	transporters	transporter	NOUN
admet-376	700	7	:	:	PUNCT
admet-376	700	8	ensuring	ensure	VERB
admet-376	700	9	that	that	SCONJ
admet-376	700	10	you	you	PRON
admet-376	700	11	get	get	VERB
admet-376	700	12	and	and	CCONJ
admet-376	700	13	keep	keep	VERB
admet-376	700	14	your	your	PRON
admet-376	700	15	daily	daily	ADJ
admet-376	700	16	dose	dose	NOUN
admet-376	700	17	of	of	ADP
admet-376	700	18	vitamin	vitamin	NOUN
admet-376	700	19	c	c	NOUN
admet-376	700	20	,	,	PUNCT
admet-376	700	21	br	br	PROPN
admet-376	700	22	j	j	PROPN
admet-376	700	23	pharmacol	pharmacol	PROPN
admet-376	700	24	164	164	NUM
admet-376	700	25	(	(	PUNCT
admet-376	700	26	2011	2011	NUM
admet-376	700	27	)	)	PUNCT
admet-376	700	28	1793	1793	NUM
admet-376	700	29	-	-	SYM
admet-376	700	30	1801	1801	NUM
admet-376	700	31	.	.	PUNCT
admet-376	701	1	[	[	X
admet-376	701	2	197	197	NUM
admet-376	701	3	]	]	PUNCT
admet-376	701	4	z.	z.	PROPN
admet-376	701	5	hou	hou	PROPN
admet-376	701	6	,	,	PUNCT
admet-376	701	7	l.h	l.h	PROPN
admet-376	701	8	.	.	PROPN
admet-376	701	9	matherly	matherly	ADV
admet-376	701	10	.	.	PUNCT
admet-376	702	1	biology	biology	NOUN
admet-376	702	2	of	of	ADP
admet-376	702	3	the	the	DET
admet-376	702	4	major	major	ADJ
admet-376	702	5	facilitative	facilitative	ADJ
admet-376	702	6	folate	folate	NOUN
admet-376	702	7	transporters	transporter	NOUN
admet-376	702	8	slc19a1	slc19a1	ADJ
admet-376	702	9	and	and	CCONJ
admet-376	702	10	slc46a1	slc46a1	ADJ
admet-376	702	11	,	,	PUNCT
admet-376	702	12	curr	curr	X
admet-376	702	13	top	top	ADJ
admet-376	702	14	membr	membr	NOUN
admet-376	702	15	73	73	NUM
admet-376	702	16	(	(	PUNCT
admet-376	702	17	2014	2014	NUM
admet-376	702	18	)	)	PUNCT
admet-376	702	19	175	175	NUM
admet-376	702	20	-	-	SYM
admet-376	702	21	204	204	NUM
admet-376	702	22	.	.	PUNCT
admet-376	703	1	[	[	X
admet-376	703	2	198	198	NUM
admet-376	703	3	]	]	X
admet-376	703	4	a.h	a.h	PROPN
admet-376	703	5	.	.	PROPN
admet-376	703	6	laftah	laftah	PROPN
admet-376	703	7	,	,	PUNCT
admet-376	703	8	g.o	g.o	PROPN
admet-376	703	9	.	.	PROPN
admet-376	703	10	latunde	latunde	PROPN
admet-376	703	11	-	-	PUNCT
admet-376	703	12	dada	dada	PROPN
admet-376	703	13	,	,	PUNCT
admet-376	703	14	s.	s.	PROPN
admet-376	703	15	fakih	fakih	PROPN
admet-376	703	16	,	,	PUNCT
admet-376	703	17	r.c	r.c	PROPN
admet-376	703	18	.	.	PROPN
admet-376	703	19	hider	hider	PROPN
admet-376	703	20	,	,	PUNCT
admet-376	703	21	r.j	r.j	PROPN
admet-376	703	22	.	.	PROPN
admet-376	703	23	simpson	simpson	PROPN
admet-376	703	24	,	,	PUNCT
admet-376	703	25	a.t	a.t	PROPN
admet-376	703	26	.	.	PROPN
admet-376	703	27	mckie	mckie	PROPN
admet-376	703	28	.	.	PUNCT
admet-376	704	1	haem	haem	NOUN
admet-376	704	2	and	and	CCONJ
admet-376	704	3	folate	folate	NOUN
admet-376	704	4	transport	transport	NOUN
admet-376	704	5	by	by	ADP
admet-376	704	6	proton	proton	NOUN
admet-376	704	7	-	-	PUNCT
admet-376	704	8	coupled	couple	VERB
admet-376	704	9	folate	folate	NOUN
admet-376	704	10	transporter	transporter	NOUN
admet-376	704	11	/	/	SYM
admet-376	704	12	haem	haem	NOUN
admet-376	704	13	carrier	carrier	NOUN
admet-376	704	14	protein	protein	NOUN
admet-376	704	15	1	1	NUM
admet-376	704	16	(	(	PUNCT
admet-376	704	17	slc46a1	slc46a1	ADJ
admet-376	704	18	)	)	PUNCT
admet-376	704	19	,	,	PUNCT
admet-376	704	20	br	br	PROPN
admet-376	704	21	j	j	PROPN
admet-376	704	22	nutr	nutr	PROPN
admet-376	704	23	101	101	NUM
admet-376	704	24	(	(	PUNCT
admet-376	704	25	2009	2009	NUM
admet-376	704	26	)	)	PUNCT
admet-376	704	27	1150	1150	NUM
admet-376	704	28	-	-	SYM
admet-376	704	29	1156	1156	NUM
admet-376	704	30	.	.	PUNCT
admet-376	705	1	[	[	X
admet-376	705	2	199	199	NUM
admet-376	705	3	]	]	X
admet-376	705	4	l.h	l.h	PROPN
admet-376	705	5	.	.	PROPN
admet-376	706	1	matherly	matherly	ADV
admet-376	706	2	,	,	PUNCT
admet-376	706	3	m.r	m.r	PROPN
admet-376	706	4	.	.	PROPN
admet-376	706	5	wilson	wilson	PROPN
admet-376	706	6	,	,	PUNCT
admet-376	706	7	z.	z.	PROPN
admet-376	706	8	hou	hou	PROPN
admet-376	706	9	.	.	PUNCT
admet-376	707	1	the	the	DET
admet-376	707	2	major	major	ADJ
admet-376	707	3	facilitative	facilitative	ADJ
admet-376	707	4	folate	folate	NOUN
admet-376	707	5	transporters	transporter	NOUN
admet-376	707	6	solute	solute	ADJ
admet-376	707	7	carrier	carrier	NOUN
admet-376	707	8	19a1	19a1	PROPN
admet-376	707	9	and	and	CCONJ
admet-376	707	10	solute	solute	ADJ
admet-376	707	11	carrier	carrier	NOUN
admet-376	707	12	46a1	46a1	NUM
admet-376	707	13	:	:	PUNCT
admet-376	707	14	biology	biology	NOUN
admet-376	707	15	and	and	CCONJ
admet-376	707	16	role	role	NOUN
admet-376	707	17	in	in	ADP
admet-376	707	18	antifolate	antifolate	NOUN
admet-376	707	19	chemotherapy	chemotherapy	NOUN
admet-376	707	20	of	of	ADP
admet-376	707	21	cancer	cancer	NOUN
admet-376	707	22	,	,	PUNCT
admet-376	707	23	drug	drug	NOUN
admet-376	707	24	metab	metab	NOUN
admet-376	707	25	dispos	dispos	PROPN
admet-376	707	26	42	42	NUM
admet-376	707	27	(	(	PUNCT
admet-376	707	28	2014	2014	NUM
admet-376	707	29	)	)	PUNCT
admet-376	707	30	632	632	NUM
admet-376	707	31	-	-	SYM
admet-376	707	32	649	649	NUM
admet-376	707	33	.	.	PUNCT
admet-376	708	1	[	[	X
admet-376	708	2	200	200	NUM
admet-376	708	3	]	]	X
admet-376	708	4	y.	y.	PROPN
admet-376	708	5	uchida	uchida	PROPN
admet-376	708	6	,	,	PUNCT
admet-376	708	7	k.	k.	PROPN
admet-376	708	8	ito	ito	PROPN
admet-376	708	9	,	,	PUNCT
admet-376	708	10	s.	s.	PROPN
admet-376	708	11	ohtsuki	ohtsuki	PROPN
admet-376	708	12	,	,	PUNCT
admet-376	708	13	y.	y.	PROPN
admet-376	708	14	kubo	kubo	PROPN
admet-376	708	15	,	,	PUNCT
admet-376	708	16	t.	t.	PROPN
admet-376	708	17	suzuki	suzuki	PROPN
admet-376	708	18	,	,	PUNCT
admet-376	708	19	t.	t.	PROPN
admet-376	708	20	terasaki	terasaki	PROPN
admet-376	708	21	.	.	PUNCT
admet-376	709	1	major	major	ADJ
admet-376	709	2	involvement	involvement	NOUN
admet-376	709	3	of	of	ADP
admet-376	709	4	na+	na+	NOUN
admet-376	709	5	-dependent	-dependent	ADJ
admet-376	709	6	multivitamin	multivitamin	NOUN
admet-376	709	7	transporter	transporter	NOUN
admet-376	709	8	(	(	PUNCT
admet-376	709	9	slc5a6	slc5a6	NOUN
admet-376	709	10	/	/	SYM
admet-376	709	11	smvt	smvt	NOUN
admet-376	709	12	)	)	PUNCT
admet-376	709	13	in	in	ADP
admet-376	709	14	uptake	uptake	NOUN
admet-376	709	15	of	of	ADP
admet-376	709	16	biotin	biotin	NOUN
admet-376	709	17	and	and	CCONJ
admet-376	709	18	pantothenic	pantothenic	ADJ
admet-376	709	19	acid	acid	NOUN
admet-376	709	20	by	by	ADP
admet-376	709	21	human	human	ADJ
admet-376	709	22	brain	brain	NOUN
admet-376	709	23	capillary	capillary	ADJ
admet-376	709	24	endothelial	endothelial	ADJ
admet-376	709	25	cells	cell	NOUN
admet-376	709	26	,	,	PUNCT
admet-376	709	27	j	j	PROPN
admet-376	709	28	neurochem	neurochem	ADV
admet-376	709	29	134	134	NUM
admet-376	709	30	(	(	PUNCT
admet-376	709	31	2015	2015	NUM
admet-376	709	32	)	)	PUNCT
admet-376	709	33	97	97	NUM
admet-376	709	34	-	-	SYM
admet-376	709	35	112	112	NUM
admet-376	709	36	.	.	PUNCT
admet-376	710	1	[	[	X
admet-376	710	2	201	201	NUM
admet-376	710	3	]	]	X
admet-376	710	4	l.	l.	PROPN
admet-376	710	5	jeanguenin	jeanguenin	PROPN
admet-376	710	6	,	,	PUNCT
admet-376	710	7	a.	a.	PROPN
admet-376	710	8	lara	lara	PROPN
admet-376	710	9	-	-	PUNCT
admet-376	710	10	nunez	nunez	PROPN
admet-376	710	11	,	,	PUNCT
admet-376	710	12	d.a	d.a	PROPN
admet-376	710	13	.	.	PROPN
admet-376	710	14	rodionov	rodionov	PROPN
admet-376	710	15	,	,	PUNCT
admet-376	710	16	a.l	a.l	PROPN
admet-376	710	17	.	.	PROPN
admet-376	710	18	osterman	osterman	PROPN
admet-376	710	19	,	,	PUNCT
admet-376	710	20	n.y	n.y	PROPN
admet-376	710	21	.	.	PROPN
admet-376	710	22	komarova	komarova	PROPN
admet-376	710	23	,	,	PUNCT
admet-376	710	24	d.	d.	PROPN
admet-376	710	25	rentsch	rentsch	PROPN
admet-376	710	26	,	,	PUNCT
admet-376	710	27	j.f	j.f	PROPN
admet-376	710	28	.	.	PROPN
admet-376	710	29	gregory	gregory	PROPN
admet-376	710	30	,	,	PUNCT
admet-376	710	31	3rd	3rd	PROPN
admet-376	710	32	,	,	PUNCT
admet-376	710	33	a.d	a.d	PROPN
admet-376	710	34	.	.	PROPN
admet-376	710	35	hanson	hanson	PROPN
admet-376	710	36	.	.	PUNCT
admet-376	711	1	comparative	comparative	ADJ
admet-376	711	2	genomics	genomic	NOUN
admet-376	711	3	and	and	CCONJ
admet-376	711	4	functional	functional	ADJ
admet-376	711	5	analysis	analysis	NOUN
admet-376	711	6	of	of	ADP
admet-376	711	7	the	the	DET
admet-376	711	8	niap	niap	PROPN
admet-376	711	9	family	family	NOUN
admet-376	711	10	uncover	uncover	VERB
admet-376	711	11	nicotinate	nicotinate	ADJ
admet-376	711	12	transporters	transporter	NOUN
admet-376	711	13	from	from	ADP
admet-376	711	14	bacteria	bacteria	NOUN
admet-376	711	15	,	,	PUNCT
admet-376	711	16	plants	plant	NOUN
admet-376	711	17	,	,	PUNCT
admet-376	711	18	and	and	CCONJ
admet-376	711	19	mammals	mammal	NOUN
admet-376	711	20	,	,	PUNCT
admet-376	711	21	funct	funct	ADJ
admet-376	711	22	integr	integr	NOUN
admet-376	711	23	genomics	genomics	PROPN
admet-376	711	24	12	12	NUM
admet-376	711	25	(	(	PUNCT
admet-376	711	26	2012	2012	NUM
admet-376	711	27	)	)	PUNCT
admet-376	711	28	25	25	NUM
admet-376	711	29	-	-	SYM
admet-376	711	30	34	34	NUM
admet-376	711	31	.	.	PUNCT
admet-376	712	1	[	[	X
admet-376	712	2	202	202	NUM
admet-376	712	3	]	]	PUNCT
admet-376	712	4	l.	l.	PROPN
admet-376	712	5	chen	chen	PROPN
admet-376	712	6	,	,	PUNCT
admet-376	712	7	y.	y.	PROPN
admet-376	712	8	shu	shu	PROPN
admet-376	712	9	,	,	PUNCT
admet-376	712	10	x.	x.	PROPN
admet-376	712	11	liang	liang	PROPN
admet-376	712	12	,	,	PUNCT
admet-376	712	13	e.c	e.c	PROPN
admet-376	712	14	.	.	PROPN
admet-376	712	15	chen	chen	PROPN
admet-376	712	16	,	,	PUNCT
admet-376	712	17	s.w	s.w	PROPN
admet-376	712	18	.	.	PROPN
admet-376	712	19	yee	yee	PROPN
admet-376	712	20	,	,	PUNCT
admet-376	712	21	a.a	a.a	PROPN
admet-376	712	22	.	.	PROPN
admet-376	712	23	zur	zur	PROPN
admet-376	712	24	,	,	PUNCT
admet-376	712	25	s.	s.	PROPN
admet-376	712	26	li	li	PROPN
admet-376	712	27	,	,	PUNCT
admet-376	712	28	l.	l.	PROPN
admet-376	712	29	xu	xu	PROPN
admet-376	712	30	,	,	PUNCT
admet-376	712	31	k.r	k.r	PROPN
admet-376	712	32	.	.	PROPN
admet-376	712	33	keshari	keshari	PROPN
admet-376	712	34	,	,	PUNCT
admet-376	712	35	m.j	m.j	PROPN
admet-376	712	36	.	.	PROPN
admet-376	712	37	lin	lin	PROPN
admet-376	712	38	,	,	PUNCT
admet-376	712	39	h.c	h.c	PROPN
admet-376	712	40	.	.	PROPN
admet-376	712	41	chien	chien	PROPN
admet-376	712	42	,	,	PUNCT
admet-376	712	43	y.	y.	PROPN
admet-376	712	44	zhang	zhang	PROPN
admet-376	712	45	,	,	PUNCT
admet-376	712	46	k.m	k.m	PROPN
admet-376	712	47	.	.	PROPN
admet-376	712	48	morrissey	morrissey	PROPN
admet-376	712	49	,	,	PUNCT
admet-376	712	50	j.	j.	PROPN
admet-376	712	51	liu	liu	PROPN
admet-376	712	52	,	,	PUNCT
admet-376	712	53	j.	j.	PROPN
admet-376	712	54	ostrem	ostrem	PROPN
admet-376	712	55	,	,	PUNCT
admet-376	712	56	n.s	n.s	PROPN
admet-376	712	57	.	.	PROPN
admet-376	712	58	younger	young	ADJ
admet-376	712	59	,	,	PUNCT
admet-376	712	60	j.	j.	PROPN
admet-376	712	61	kurhanewicz	kurhanewicz	PROPN
admet-376	712	62	,	,	PUNCT
admet-376	712	63	k.m	k.m	PROPN
admet-376	712	64	.	.	PROPN
admet-376	712	65	shokat	shokat	PROPN
admet-376	712	66	,	,	PUNCT
admet-376	712	67	k.	k.	PROPN
admet-376	712	68	ashrafi	ashrafi	PROPN
admet-376	712	69	,	,	PUNCT
admet-376	712	70	k.m	k.m	PROPN
admet-376	712	71	.	.	PROPN
admet-376	712	72	giacomini	giacomini	PROPN
admet-376	712	73	.	.	PUNCT
admet-376	712	74	oct1	oct1	PROPN
admet-376	712	75	is	be	AUX
admet-376	712	76	a	a	DET
admet-376	712	77	high	high	ADJ
admet-376	712	78	-	-	PUNCT
admet-376	712	79	capacity	capacity	NOUN
admet-376	712	80	thiamine	thiamine	NOUN
admet-376	712	81	transporter	transporter	NOUN
admet-376	712	82	that	that	PRON
admet-376	712	83	regulates	regulate	VERB
admet-376	712	84	hepatic	hepatic	ADJ
admet-376	712	85	steatosis	steatosis	NOUN
admet-376	712	86	and	and	CCONJ
admet-376	712	87	is	be	AUX
admet-376	712	88	a	a	DET
admet-376	712	89	target	target	NOUN
admet-376	712	90	of	of	ADP
admet-376	712	91	metformin	metformin	NOUN
admet-376	712	92	,	,	PUNCT
admet-376	712	93	proc	proc	PROPN
admet-376	712	94	natl	natl	PROPN
admet-376	712	95	acad	acad	PROPN
admet-376	712	96	sci	sci	PROPN
admet-376	712	97	u	u	PROPN
admet-376	712	98	s	s	PROPN
admet-376	712	99	a	a	DET
admet-376	712	100	111	111	NUM
admet-376	712	101	(	(	PUNCT
admet-376	712	102	2014	2014	NUM
admet-376	712	103	)	)	PUNCT
admet-376	712	104	9983	9983	NUM
admet-376	712	105	-	-	SYM
admet-376	712	106	9988	9988	NUM
admet-376	712	107	.	.	PUNCT
admet-376	713	1	[	[	X
admet-376	713	2	203	203	NUM
admet-376	713	3	]	]	X
admet-376	713	4	v.	v.	ADP
admet-376	713	5	ganapathy	ganapathy	PROPN
admet-376	713	6	,	,	PUNCT
admet-376	713	7	s.b	s.b	PROPN
admet-376	713	8	.	.	PROPN
admet-376	713	9	smith	smith	PROPN
admet-376	713	10	,	,	PUNCT
admet-376	713	11	p.d	p.d	PROPN
admet-376	713	12	.	.	PROPN
admet-376	713	13	prasad	prasad	PROPN
admet-376	713	14	.	.	PUNCT
admet-376	714	1	slc19	slc19	NOUN
admet-376	714	2	:	:	PUNCT
admet-376	714	3	the	the	DET
admet-376	714	4	folate	folate	NOUN
admet-376	714	5	/	/	SYM
admet-376	714	6	thiamine	thiamine	NOUN
admet-376	714	7	transporter	transporter	NOUN
admet-376	714	8	family	family	NOUN
admet-376	714	9	,	,	PUNCT
admet-376	714	10	pflugers	pfluger	NOUN
admet-376	714	11	arch	arch	VERB
admet-376	714	12	447	447	NUM
admet-376	714	13	(	(	PUNCT
admet-376	714	14	2004	2004	NUM
admet-376	714	15	)	)	PUNCT
admet-376	714	16	641	641	NUM
admet-376	714	17	-	-	SYM
admet-376	714	18	646	646	NUM
admet-376	714	19	.	.	PUNCT
admet-376	715	1	[	[	X
admet-376	715	2	204	204	NUM
admet-376	715	3	]	]	PUNCT
admet-376	715	4	r.	r.	PROPN
admet-376	715	5	zhao	zhao	PROPN
admet-376	715	6	,	,	PUNCT
admet-376	715	7	i.d	i.d	PROPN
admet-376	715	8	.	.	PROPN
admet-376	715	9	goldman	goldman	PROPN
admet-376	715	10	.	.	PUNCT
admet-376	716	1	folate	folate	NOUN
admet-376	716	2	and	and	CCONJ
admet-376	716	3	thiamine	thiamine	NOUN
admet-376	716	4	transporters	transporter	NOUN
admet-376	716	5	mediated	mediate	VERB
admet-376	716	6	by	by	ADP
admet-376	716	7	facilitative	facilitative	ADJ
admet-376	716	8	carriers	carrier	NOUN
admet-376	716	9	(	(	PUNCT
admet-376	716	10	slc19a1	slc19a1	PROPN
admet-376	716	11	-	-	PUNCT
admet-376	716	12	3	3	NUM
admet-376	716	13	and	and	CCONJ
admet-376	716	14	slc46a1	slc46a1	ADJ
admet-376	716	15	)	)	PUNCT
admet-376	716	16	and	and	CCONJ
admet-376	716	17	folate	folate	NOUN
admet-376	716	18	receptors	receptor	NOUN
admet-376	716	19	,	,	PUNCT
admet-376	716	20	mol	mol	ADP
admet-376	716	21	aspects	aspect	NOUN
admet-376	716	22	med	me	VERB
admet-376	716	23	34	34	NUM
admet-376	716	24	(	(	PUNCT
admet-376	716	25	2013	2013	NUM
admet-376	716	26	)	)	PUNCT
admet-376	716	27	373	373	NUM
admet-376	716	28	-	-	SYM
admet-376	716	29	385	385	NUM
admet-376	716	30	.	.	PUNCT
admet-376	716	31	o'hagan	o'hagan	PROPN
admet-376	716	32	&	&	CCONJ
admet-376	716	33	kell	kell	PROPN
admet-376	716	34	admet	admet	PROPN
admet-376	716	35	&	&	CCONJ
admet-376	716	36	dmpk	dmpk	PROPN
admet-376	716	37	5(2	5(2	NUM
admet-376	716	38	)	)	PUNCT
admet-376	716	39	(	(	PUNCT
admet-376	716	40	2017	2017	NUM
admet-376	716	41	)	)	PUNCT
admet-376	716	42	85	85	NUM
admet-376	716	43	-	-	SYM
admet-376	716	44	125	125	NUM
admet-376	716	45	124	124	NUM
admet-376	716	46	[	[	X
admet-376	716	47	205	205	NUM
admet-376	716	48	]	]	X
admet-376	716	49	j.d	j.d	PROPN
admet-376	716	50	.	.	PROPN
admet-376	716	51	ortigoza	ortigoza	PROPN
admet-376	716	52	-	-	PUNCT
admet-376	716	53	escobar	escobar	PROPN
admet-376	716	54	,	,	PUNCT
admet-376	716	55	m.	m.	NOUN
admet-376	716	56	molero	molero	PROPN
admet-376	716	57	-	-	PUNCT
admet-376	716	58	luis	luis	PROPN
admet-376	716	59	,	,	PUNCT
admet-376	716	60	a.	a.	NOUN
admet-376	716	61	arias	arias	PROPN
admet-376	716	62	,	,	PUNCT
admet-376	716	63	a.	a.	NOUN
admet-376	716	64	oyarzabal	oyarzabal	PROPN
admet-376	716	65	,	,	PUNCT
admet-376	716	66	n.	n.	PROPN
admet-376	716	67	darin	darin	PROPN
admet-376	716	68	,	,	PUNCT
admet-376	716	69	m.	m.	NOUN
admet-376	716	70	serrano	serrano	PROPN
admet-376	716	71	,	,	PUNCT
admet-376	716	72	a.	a.	PROPN
admet-376	716	73	garcia	garcia	PROPN
admet-376	716	74	-	-	PUNCT
admet-376	716	75	cazorla	cazorla	PROPN
admet-376	716	76	,	,	PUNCT
admet-376	716	77	m.	m.	NOUN
admet-376	716	78	tondo	tondo	PROPN
admet-376	716	79	,	,	PUNCT
admet-376	716	80	m.	m.	NOUN
admet-376	716	81	hernández	hernández	PROPN
admet-376	716	82	,	,	PUNCT
admet-376	716	83	j.	j.	PROPN
admet-376	716	84	garcia	garcia	PROPN
admet-376	716	85	-	-	PUNCT
admet-376	716	86	villoria	villoria	PROPN
admet-376	716	87	,	,	PUNCT
admet-376	716	88	m.	m.	NOUN
admet-376	716	89	casado	casado	PROPN
admet-376	716	90	,	,	PUNCT
admet-376	716	91	l.	l.	PROPN
admet-376	716	92	gort	gort	PROPN
admet-376	716	93	,	,	PUNCT
admet-376	716	94	j.a	j.a	PROPN
admet-376	716	95	.	.	PROPN
admet-376	716	96	mayr	mayr	PROPN
admet-376	716	97	,	,	PUNCT
admet-376	716	98	p.	p.	PROPN
admet-376	716	99	rodríguez	rodríguez	PROPN
admet-376	716	100	-	-	PUNCT
admet-376	716	101	pombo	pombo	PROPN
admet-376	716	102	,	,	PUNCT
admet-376	716	103	a.	a.	NOUN
admet-376	716	104	ribes	ribe	NOUN
admet-376	716	105	,	,	PUNCT
admet-376	716	106	r.	r.	PROPN
admet-376	716	107	artuch	artuch	PROPN
admet-376	716	108	,	,	PUNCT
admet-376	716	109	b.	b.	PROPN
admet-376	716	110	pérez	pérez	NOUN
admet-376	716	111	-	-	PUNCT
admet-376	716	112	dueñas	dueñas	NOUN
admet-376	716	113	.	.	PUNCT
admet-376	717	1	free	free	ADJ
admet-376	717	2	-	-	PUNCT
admet-376	717	3	thiamine	thiamine	NOUN
admet-376	717	4	is	be	AUX
admet-376	717	5	a	a	DET
admet-376	717	6	potential	potential	ADJ
admet-376	717	7	biomarker	biomarker	NOUN
admet-376	717	8	of	of	ADP
admet-376	717	9	thiamine	thiamine	NOUN
admet-376	717	10	transporter-2	transporter-2	NUM
admet-376	717	11	deficiency	deficiency	NOUN
admet-376	717	12	:	:	PUNCT
admet-376	717	13	a	a	DET
admet-376	717	14	treatable	treatable	ADJ
admet-376	717	15	cause	cause	NOUN
admet-376	717	16	of	of	ADP
admet-376	717	17	leigh	leigh	PROPN
admet-376	717	18	syndrome	syndrome	NOUN
admet-376	717	19	,	,	PUNCT
admet-376	717	20	brain	brain	NOUN
admet-376	717	21	139	139	NUM
admet-376	717	22	(	(	PUNCT
admet-376	717	23	2016	2016	NUM
admet-376	717	24	)	)	PUNCT
admet-376	717	25	31	31	NUM
admet-376	717	26	-	-	SYM
admet-376	717	27	38	38	NUM
admet-376	717	28	.	.	PUNCT
admet-376	718	1	[	[	X
admet-376	718	2	206	206	NUM
admet-376	718	3	]	]	PUNCT
admet-376	718	4	m.	m.	NOUN
admet-376	718	5	fujimura	fujimura	PROPN
admet-376	718	6	,	,	PUNCT
admet-376	718	7	s.	s.	PROPN
admet-376	718	8	yamamoto	yamamoto	PROPN
admet-376	718	9	,	,	PUNCT
admet-376	718	10	t.	t.	PROPN
admet-376	718	11	murata	murata	PROPN
admet-376	718	12	,	,	PUNCT
admet-376	718	13	t.	t.	PROPN
admet-376	718	14	yasujima	yasujima	PROPN
admet-376	718	15	,	,	PUNCT
admet-376	718	16	k.	k.	PROPN
admet-376	718	17	inoue	inoue	PROPN
admet-376	718	18	,	,	PUNCT
admet-376	718	19	k.y	k.y	PROPN
admet-376	718	20	.	.	PROPN
admet-376	718	21	ohta	ohta	PROPN
admet-376	718	22	,	,	PUNCT
admet-376	718	23	h.	h.	PROPN
admet-376	718	24	yuasa	yuasa	PROPN
admet-376	718	25	.	.	PUNCT
admet-376	719	1	functional	functional	ADJ
admet-376	719	2	characteristics	characteristic	NOUN
admet-376	719	3	of	of	ADP
admet-376	719	4	the	the	DET
admet-376	719	5	human	human	ADJ
admet-376	719	6	ortholog	ortholog	NOUN
admet-376	719	7	of	of	ADP
admet-376	719	8	riboflavin	riboflavin	NOUN
admet-376	719	9	transporter	transporter	NOUN
admet-376	719	10	2	2	NUM
admet-376	719	11	and	and	CCONJ
admet-376	719	12	riboflavin	riboflavin	NOUN
admet-376	719	13	-	-	PUNCT
admet-376	719	14	responsive	responsive	ADJ
admet-376	719	15	expression	expression	NOUN
admet-376	719	16	of	of	ADP
admet-376	719	17	its	its	PRON
admet-376	719	18	rat	rat	NOUN
admet-376	719	19	ortholog	ortholog	NOUN
admet-376	719	20	in	in	ADP
admet-376	719	21	the	the	DET
admet-376	719	22	small	small	ADJ
admet-376	719	23	intestine	intestine	NOUN
admet-376	719	24	indicate	indicate	VERB
admet-376	719	25	its	its	PRON
admet-376	719	26	involvement	involvement	NOUN
admet-376	719	27	in	in	ADP
admet-376	719	28	riboflavin	riboflavin	NOUN
admet-376	719	29	absorption	absorption	NOUN
admet-376	719	30	,	,	PUNCT
admet-376	719	31	j	j	PROPN
admet-376	719	32	nutr	nutr	PROPN
admet-376	719	33	140	140	NUM
admet-376	719	34	(	(	PUNCT
admet-376	719	35	2010	2010	NUM
admet-376	719	36	)	)	PUNCT
admet-376	719	37	1722	1722	NUM
admet-376	719	38	-	-	SYM
admet-376	719	39	1727	1727	NUM
admet-376	719	40	.	.	PUNCT
admet-376	720	1	[	[	X
admet-376	720	2	207	207	NUM
admet-376	720	3	]	]	X
admet-376	720	4	y.	y.	PROPN
admet-376	720	5	moriyama	moriyama	PROPN
admet-376	720	6	.	.	PUNCT
admet-376	721	1	riboflavin	riboflavin	NOUN
admet-376	721	2	transporter	transporter	NOUN
admet-376	721	3	is	be	AUX
admet-376	721	4	finally	finally	ADV
admet-376	721	5	identified	identify	VERB
admet-376	721	6	,	,	PUNCT
admet-376	721	7	journal	journal	NOUN
admet-376	721	8	of	of	ADP
admet-376	721	9	biochemistry	biochemistry	NOUN
admet-376	721	10	150	150	NUM
admet-376	721	11	(	(	PUNCT
admet-376	721	12	2011	2011	NUM
admet-376	721	13	)	)	PUNCT
admet-376	721	14	341	341	NUM
admet-376	721	15	-	-	NUM
admet-376	721	16	343	343	NUM
admet-376	721	17	.	.	PUNCT
admet-376	722	1	[	[	X
admet-376	722	2	208	208	NUM
admet-376	722	3	]	]	PUNCT
admet-376	722	4	a.	a.	NOUN
admet-376	722	5	yonezawa	yonezawa	PROPN
admet-376	722	6	,	,	PUNCT
admet-376	722	7	k.	k.	PROPN
admet-376	722	8	inui	inui	PROPN
admet-376	722	9	.	.	PUNCT
admet-376	723	1	novel	novel	ADJ
admet-376	723	2	riboflavin	riboflavin	NOUN
admet-376	723	3	transporter	transporter	NOUN
admet-376	723	4	family	family	NOUN
admet-376	723	5	rfvt	rfvt	NOUN
admet-376	723	6	/	/	SYM
admet-376	723	7	slc52	slc52	ADJ
admet-376	723	8	:	:	PUNCT
admet-376	723	9	identification	identification	NOUN
admet-376	723	10	,	,	PUNCT
admet-376	723	11	nomenclature	nomenclature	NOUN
admet-376	723	12	,	,	PUNCT
admet-376	723	13	functional	functional	ADJ
admet-376	723	14	characterization	characterization	NOUN
admet-376	723	15	and	and	CCONJ
admet-376	723	16	genetic	genetic	ADJ
admet-376	723	17	diseases	disease	NOUN
admet-376	723	18	of	of	ADP
admet-376	723	19	rfvt	rfvt	NOUN
admet-376	723	20	/	/	SYM
admet-376	723	21	slc52	slc52	NOUN
admet-376	723	22	,	,	PUNCT
admet-376	723	23	mol	mol	ADP
admet-376	723	24	aspects	aspect	NOUN
admet-376	723	25	med	me	VERB
admet-376	723	26	34	34	NUM
admet-376	723	27	(	(	PUNCT
admet-376	723	28	2013	2013	NUM
admet-376	723	29	)	)	PUNCT
admet-376	723	30	693	693	NUM
admet-376	723	31	-	-	SYM
admet-376	723	32	701	701	NUM
admet-376	723	33	.	.	PUNCT
admet-376	724	1	[	[	X
admet-376	724	2	209	209	NUM
admet-376	724	3	]	]	X
admet-376	724	4	s.	s.	PROPN
admet-376	724	5	sabui	sabui	PROPN
admet-376	724	6	,	,	PUNCT
admet-376	724	7	a.	a.	PROPN
admet-376	724	8	ghosal	ghosal	PROPN
admet-376	724	9	,	,	PUNCT
admet-376	724	10	h.m	h.m	PROPN
admet-376	724	11	.	.	PROPN
admet-376	724	12	said	say	VERB
admet-376	724	13	.	.	PUNCT
admet-376	725	1	identification	identification	NOUN
admet-376	725	2	and	and	CCONJ
admet-376	725	3	characterization	characterization	NOUN
admet-376	725	4	of	of	ADP
admet-376	725	5	5'-flanking	5'-flanke	VERB
admet-376	725	6	region	region	NOUN
admet-376	725	7	of	of	ADP
admet-376	725	8	the	the	DET
admet-376	725	9	human	human	ADJ
admet-376	725	10	riboflavin	riboflavin	NOUN
admet-376	725	11	transporter	transporter	NOUN
admet-376	725	12	1	1	NUM
admet-376	725	13	gene	gene	NOUN
admet-376	725	14	(	(	PUNCT
admet-376	725	15	slc52a1	slc52a1	PROPN
admet-376	725	16	)	)	PUNCT
admet-376	725	17	,	,	PUNCT
admet-376	725	18	gene	gene	NOUN
admet-376	725	19	553	553	NUM
admet-376	725	20	(	(	PUNCT
admet-376	725	21	2014	2014	NUM
admet-376	725	22	)	)	PUNCT
admet-376	725	23	49	49	NUM
admet-376	725	24	-	-	SYM
admet-376	725	25	56	56	NUM
admet-376	725	26	.	.	PUNCT
admet-376	726	1	[	[	X
admet-376	726	2	210	210	NUM
admet-376	726	3	]	]	PUNCT
admet-376	726	4	a.	a.	NOUN
admet-376	726	5	ghosal	ghosal	PROPN
admet-376	726	6	,	,	PUNCT
admet-376	726	7	s.	s.	PROPN
admet-376	726	8	sabui	sabui	PROPN
admet-376	726	9	,	,	PUNCT
admet-376	726	10	h.m	h.m	PROPN
admet-376	726	11	.	.	PROPN
admet-376	726	12	said	say	VERB
admet-376	726	13	.	.	PUNCT
admet-376	727	1	identification	identification	NOUN
admet-376	727	2	and	and	CCONJ
admet-376	727	3	characterization	characterization	NOUN
admet-376	727	4	of	of	ADP
admet-376	727	5	the	the	DET
admet-376	727	6	minimal	minimal	ADJ
admet-376	727	7	5'-regulatory	5'-regulatory	ADJ
admet-376	727	8	region	region	NOUN
admet-376	727	9	of	of	ADP
admet-376	727	10	the	the	DET
admet-376	727	11	human	human	ADJ
admet-376	727	12	riboflavin	riboflavin	NOUN
admet-376	727	13	transporter-3	transporter-3	NUM
admet-376	727	14	(	(	PUNCT
admet-376	727	15	slc52a3	slc52a3	PROPN
admet-376	727	16	)	)	PUNCT
admet-376	727	17	in	in	ADP
admet-376	727	18	intestinal	intestinal	ADJ
admet-376	727	19	epithelial	epithelial	ADJ
admet-376	727	20	cells	cell	NOUN
admet-376	727	21	,	,	PUNCT
admet-376	727	22	am	be	AUX
admet-376	727	23	j	j	PROPN
admet-376	727	24	physiol	physiol	PROPN
admet-376	727	25	cell	cell	PROPN
admet-376	727	26	physiol	physiol	PROPN
admet-376	727	27	308	308	NUM
admet-376	727	28	(	(	PUNCT
admet-376	727	29	2015	2015	NUM
admet-376	727	30	)	)	PUNCT
admet-376	727	31	c189	c189	PROPN
admet-376	727	32	-	-	SYM
admet-376	727	33	196	196	NUM
admet-376	727	34	.	.	PUNCT
admet-376	728	1	[	[	X
admet-376	728	2	211	211	NUM
admet-376	728	3	]	]	PUNCT
admet-376	728	4	h.	h.	NOUN
admet-376	728	5	chapy	chapy	PROPN
admet-376	728	6	,	,	PUNCT
admet-376	728	7	m.	m.	NOUN
admet-376	728	8	smirnova	smirnova	PROPN
admet-376	728	9	,	,	PUNCT
admet-376	728	10	p.	p.	PROPN
admet-376	728	11	andre	andre	PROPN
admet-376	728	12	,	,	PUNCT
admet-376	728	13	j.	j.	PROPN
admet-376	728	14	schlatter	schlatter	PROPN
admet-376	728	15	,	,	PUNCT
admet-376	728	16	f.	f.	PROPN
admet-376	728	17	chiadmi	chiadmi	PROPN
admet-376	728	18	,	,	PUNCT
admet-376	728	19	p.o	p.o	PROPN
admet-376	728	20	.	.	PROPN
admet-376	728	21	couraud	couraud	PROPN
admet-376	728	22	,	,	PUNCT
admet-376	728	23	j.m	j.m	PROPN
admet-376	728	24	.	.	PROPN
admet-376	728	25	scherrmann	scherrmann	PROPN
admet-376	728	26	,	,	PUNCT
admet-376	728	27	x.	x.	NOUN
admet-376	728	28	decleves	decleve	NOUN
admet-376	728	29	,	,	PUNCT
admet-376	728	30	s.	s.	PROPN
admet-376	728	31	cisternino	cisternino	PROPN
admet-376	728	32	.	.	PUNCT
admet-376	729	1	carrier	carrier	NOUN
admet-376	729	2	-	-	PUNCT
admet-376	729	3	mediated	mediate	VERB
admet-376	729	4	cocaine	cocaine	NOUN
admet-376	729	5	transport	transport	NOUN
admet-376	729	6	at	at	ADP
admet-376	729	7	the	the	DET
admet-376	729	8	blood	blood	NOUN
admet-376	729	9	-	-	PUNCT
admet-376	729	10	brain	brain	NOUN
admet-376	729	11	barrier	barrier	NOUN
admet-376	729	12	as	as	ADP
admet-376	729	13	a	a	DET
admet-376	729	14	putative	putative	ADJ
admet-376	729	15	mechanism	mechanism	NOUN
admet-376	729	16	in	in	ADP
admet-376	729	17	addiction	addiction	NOUN
admet-376	729	18	liability	liability	NOUN
admet-376	729	19	,	,	PUNCT
admet-376	729	20	int	int	PROPN
admet-376	729	21	j	j	PROPN
admet-376	729	22	neuropsychopharmacol	neuropsychopharmacol	NOUN
admet-376	729	23	18	18	NUM
admet-376	729	24	(	(	PUNCT
admet-376	729	25	2015	2015	NUM
admet-376	729	26	)	)	PUNCT
admet-376	729	27	.	.	PUNCT
admet-376	730	1	[	[	X
admet-376	730	2	212	212	NUM
admet-376	730	3	]	]	PUNCT
admet-376	730	4	a.	a.	NOUN
admet-376	730	5	fukada	fukada	PROPN
admet-376	730	6	,	,	PUNCT
admet-376	730	7	h.	h.	PROPN
admet-376	730	8	saito	saito	PROPN
admet-376	730	9	,	,	PUNCT
admet-376	730	10	k.	k.	PROPN
admet-376	730	11	inui	inui	PROPN
admet-376	730	12	.	.	PUNCT
admet-376	731	1	transport	transport	NOUN
admet-376	731	2	mechanisms	mechanism	NOUN
admet-376	731	3	of	of	ADP
admet-376	731	4	nicotine	nicotine	NOUN
admet-376	731	5	across	across	ADP
admet-376	731	6	the	the	DET
admet-376	731	7	human	human	ADJ
admet-376	731	8	intestinal	intestinal	ADJ
admet-376	731	9	epithelial	epithelial	ADJ
admet-376	731	10	cell	cell	NOUN
admet-376	731	11	line	line	NOUN
admet-376	731	12	caco-2	caco-2	PROPN
admet-376	731	13	,	,	PUNCT
admet-376	731	14	j	j	PROPN
admet-376	731	15	pharmacol	pharmacol	PROPN
admet-376	731	16	exp	exp	NOUN
admet-376	731	17	ther	ther	ADV
admet-376	731	18	302	302	NUM
admet-376	731	19	(	(	PUNCT
admet-376	731	20	2002	2002	NUM
admet-376	731	21	)	)	PUNCT
admet-376	731	22	532	532	NUM
admet-376	731	23	-	-	SYM
admet-376	731	24	538	538	NUM
admet-376	731	25	.	.	PUNCT
admet-376	732	1	[	[	X
admet-376	732	2	213	213	NUM
admet-376	732	3	]	]	X
admet-376	732	4	y.	y.	PROPN
admet-376	732	5	tega	tega	PROPN
admet-376	732	6	,	,	PUNCT
admet-376	732	7	y.	y.	PROPN
admet-376	732	8	kubo	kubo	PROPN
admet-376	732	9	,	,	PUNCT
admet-376	732	10	c.	c.	PROPN
admet-376	732	11	yuzurihara	yuzurihara	PROPN
admet-376	732	12	,	,	PUNCT
admet-376	732	13	s.	s.	PROPN
admet-376	732	14	akanuma	akanuma	PROPN
admet-376	732	15	,	,	PUNCT
admet-376	732	16	k.	k.	PROPN
admet-376	732	17	hosoya	hosoya	PROPN
admet-376	732	18	.	.	PUNCT
admet-376	733	1	carrier	carrier	NOUN
admet-376	733	2	-	-	PUNCT
admet-376	733	3	mediated	mediate	VERB
admet-376	733	4	transport	transport	NOUN
admet-376	733	5	of	of	ADP
admet-376	733	6	nicotine	nicotine	NOUN
admet-376	733	7	across	across	ADP
admet-376	733	8	the	the	DET
admet-376	733	9	inner	inner	ADJ
admet-376	733	10	blood	blood	NOUN
admet-376	733	11	-	-	PUNCT
admet-376	733	12	retinal	retinal	ADJ
admet-376	733	13	barrier	barrier	NOUN
admet-376	733	14	:	:	PUNCT
admet-376	733	15	involvement	involvement	NOUN
admet-376	733	16	of	of	ADP
admet-376	733	17	a	a	DET
admet-376	733	18	novel	novel	ADJ
admet-376	733	19	organic	organic	ADJ
admet-376	733	20	cation	cation	NOUN
admet-376	733	21	transporter	transporter	NOUN
admet-376	733	22	driven	drive	VERB
admet-376	733	23	by	by	ADP
admet-376	733	24	an	an	DET
admet-376	733	25	outward	outward	ADJ
admet-376	733	26	h+	h+	PUNCT
admet-376	733	27	gradient	gradient	NOUN
admet-376	733	28	,	,	PUNCT
admet-376	733	29	j	j	PROPN
admet-376	733	30	pharm	pharm	PROPN
admet-376	733	31	sci	sci	PROPN
admet-376	733	32	104	104	NUM
admet-376	733	33	(	(	PUNCT
admet-376	733	34	2015	2015	NUM
admet-376	733	35	)	)	PUNCT
admet-376	733	36	3069	3069	NUM
admet-376	733	37	-	-	SYM
admet-376	733	38	3075	3075	NUM
admet-376	733	39	.	.	PUNCT
admet-376	734	1	[	[	X
admet-376	734	2	214	214	X
admet-376	734	3	]	]	X
admet-376	734	4	y.	y.	PROPN
admet-376	734	5	tega	tega	PROPN
admet-376	734	6	,	,	PUNCT
admet-376	734	7	s.	s.	PROPN
admet-376	734	8	akanuma	akanuma	PROPN
admet-376	734	9	,	,	PUNCT
admet-376	734	10	y.	y.	PROPN
admet-376	734	11	kubo	kubo	PROPN
admet-376	734	12	,	,	PUNCT
admet-376	734	13	k.	k.	PROPN
admet-376	734	14	hosoya	hosoya	PROPN
admet-376	734	15	.	.	PUNCT
admet-376	735	1	involvement	involvement	NOUN
admet-376	735	2	of	of	ADP
admet-376	735	3	the	the	DET
admet-376	735	4	h+/organic	h+/organic	ADJ
admet-376	735	5	cation	cation	NOUN
admet-376	735	6	antiporter	antiporter	NOUN
admet-376	735	7	in	in	ADP
admet-376	735	8	nicotine	nicotine	NOUN
admet-376	735	9	transport	transport	NOUN
admet-376	735	10	in	in	ADP
admet-376	735	11	rat	rat	NOUN
admet-376	735	12	liver	liver	NOUN
admet-376	735	13	,	,	PUNCT
admet-376	735	14	drug	drug	NOUN
admet-376	735	15	metab	metab	NOUN
admet-376	735	16	dispos	dispos	PROPN
admet-376	735	17	43	43	NUM
admet-376	735	18	(	(	PUNCT
admet-376	735	19	2015	2015	NUM
admet-376	735	20	)	)	PUNCT
admet-376	735	21	89	89	NUM
admet-376	735	22	-	-	SYM
admet-376	735	23	92	92	NUM
admet-376	735	24	.	.	PUNCT
admet-376	736	1	[	[	X
admet-376	736	2	215	215	NUM
admet-376	736	3	]	]	PUNCT
admet-376	736	4	m.	m.	NOUN
admet-376	736	5	takano	takano	PROPN
admet-376	736	6	,	,	PUNCT
admet-376	736	7	m.	m.	NOUN
admet-376	736	8	nagahiro	nagahiro	PROPN
admet-376	736	9	,	,	PUNCT
admet-376	736	10	r.	r.	PROPN
admet-376	736	11	yumoto	yumoto	NOUN
admet-376	736	12	.	.	PUNCT
admet-376	737	1	transport	transport	NOUN
admet-376	737	2	mechanism	mechanism	NOUN
admet-376	737	3	of	of	ADP
admet-376	737	4	nicotine	nicotine	NOUN
admet-376	737	5	in	in	ADP
admet-376	737	6	primary	primary	ADJ
admet-376	737	7	cultured	cultured	ADJ
admet-376	737	8	alveolar	alveolar	ADJ
admet-376	737	9	epithelial	epithelial	ADJ
admet-376	737	10	cells	cell	NOUN
admet-376	737	11	,	,	PUNCT
admet-376	737	12	j	j	PROPN
admet-376	737	13	pharm	pharm	PROPN
admet-376	737	14	sci	sci	PROPN
admet-376	737	15	105	105	NUM
admet-376	737	16	(	(	PUNCT
admet-376	737	17	2016	2016	NUM
admet-376	737	18	)	)	PUNCT
admet-376	737	19	982	982	NUM
admet-376	737	20	-	-	PUNCT
admet-376	737	21	988	988	NUM
admet-376	737	22	.	.	PUNCT
admet-376	738	1	[	[	X
admet-376	738	2	216	216	NUM
admet-376	738	3	]	]	X
admet-376	738	4	y.	y.	PROPN
admet-376	738	5	tega	tega	PROPN
admet-376	738	6	,	,	PUNCT
admet-376	738	7	c.	c.	PROPN
admet-376	738	8	yuzurihara	yuzurihara	PROPN
admet-376	738	9	,	,	PUNCT
admet-376	738	10	y.	y.	PROPN
admet-376	738	11	kubo	kubo	PROPN
admet-376	738	12	,	,	PUNCT
admet-376	738	13	s.	s.	PROPN
admet-376	738	14	akanuma	akanuma	PROPN
admet-376	738	15	,	,	PUNCT
admet-376	738	16	c.	c.	PROPN
admet-376	738	17	ehrhardt	ehrhardt	PROPN
admet-376	738	18	,	,	PUNCT
admet-376	738	19	k.	k.	PROPN
admet-376	738	20	hosoya	hosoya	PROPN
admet-376	738	21	.	.	PUNCT
admet-376	739	1	functional	functional	ADJ
admet-376	739	2	expression	expression	NOUN
admet-376	739	3	of	of	ADP
admet-376	739	4	nicotine	nicotine	NOUN
admet-376	739	5	influx	influx	NOUN
admet-376	739	6	transporter	transporter	NOUN
admet-376	739	7	in	in	ADP
admet-376	739	8	a549	a549	PROPN
admet-376	739	9	human	human	ADJ
admet-376	739	10	alveolar	alveolar	ADJ
admet-376	739	11	epithelial	epithelial	ADJ
admet-376	739	12	cells	cell	NOUN
admet-376	739	13	,	,	PUNCT
admet-376	739	14	drug	drug	NOUN
admet-376	739	15	metab	metab	NOUN
admet-376	739	16	pharmacokinet	pharmacokinet	NOUN
admet-376	739	17	31	31	NUM
admet-376	739	18	(	(	PUNCT
admet-376	739	19	2016	2016	NUM
admet-376	739	20	)	)	PUNCT
admet-376	739	21	99101	99101	NUM
admet-376	739	22	.	.	PUNCT
admet-376	740	1	[	[	X
admet-376	740	2	217	217	NUM
admet-376	740	3	]	]	X
admet-376	740	4	m.w	m.w	PROPN
admet-376	740	5	.	.	PROPN
admet-376	740	6	sadiq	sadiq	PROPN
admet-376	740	7	,	,	PUNCT
admet-376	740	8	e.	e.	PROPN
admet-376	740	9	bostrom	bostrom	PROPN
admet-376	740	10	,	,	PUNCT
admet-376	740	11	r.	r.	PROPN
admet-376	740	12	keizer	keizer	PROPN
admet-376	740	13	,	,	PUNCT
admet-376	740	14	s.	s.	PROPN
admet-376	740	15	bjorkman	bjorkman	PROPN
admet-376	740	16	,	,	PUNCT
admet-376	740	17	m.	m.	NOUN
admet-376	740	18	hammarlund	hammarlund	PROPN
admet-376	740	19	-	-	PUNCT
admet-376	740	20	udenaes	udenaes	PROPN
admet-376	740	21	.	.	PUNCT
admet-376	741	1	oxymorphone	oxymorphone	VERB
admet-376	741	2	active	active	ADJ
admet-376	741	3	uptake	uptake	NOUN
admet-376	741	4	at	at	ADP
admet-376	741	5	the	the	DET
admet-376	741	6	blood	blood	NOUN
admet-376	741	7	-	-	PUNCT
admet-376	741	8	brain	brain	NOUN
admet-376	741	9	barrier	barrier	NOUN
admet-376	741	10	and	and	CCONJ
admet-376	741	11	population	population	NOUN
admet-376	741	12	modeling	modeling	NOUN
admet-376	741	13	of	of	ADP
admet-376	741	14	its	its	PRON
admet-376	741	15	pharmacokinetic	pharmacokinetic	ADJ
admet-376	741	16	-	-	PUNCT
admet-376	741	17	pharmacodynamic	pharmacodynamic	ADJ
admet-376	741	18	relationship	relationship	NOUN
admet-376	741	19	,	,	PUNCT
admet-376	741	20	j	j	PROPN
admet-376	741	21	pharm	pharm	PROPN
admet-376	741	22	sci	sci	PROPN
admet-376	741	23	102	102	NUM
admet-376	741	24	(	(	PUNCT
admet-376	741	25	2013	2013	NUM
admet-376	741	26	)	)	PUNCT
admet-376	741	27	3320	3320	NUM
admet-376	741	28	-	-	SYM
admet-376	741	29	3331	3331	NUM
admet-376	741	30	.	.	PUNCT
admet-376	742	1	[	[	X
admet-376	742	2	218	218	NUM
admet-376	742	3	]	]	PUNCT
admet-376	742	4	r.	r.	PROPN
admet-376	742	5	gharavi	gharavi	PROPN
admet-376	742	6	,	,	PUNCT
admet-376	742	7	w.	w.	PROPN
admet-376	742	8	hedrich	hedrich	PROPN
admet-376	742	9	,	,	PUNCT
admet-376	742	10	h.	h.	PROPN
admet-376	742	11	wang	wang	PROPN
admet-376	742	12	,	,	PUNCT
admet-376	742	13	h.e	h.e	PROPN
admet-376	742	14	.	.	PUNCT
admet-376	742	15	hassan	hassan	PROPN
admet-376	742	16	.	.	PUNCT
admet-376	743	1	transporter	transporter	NOUN
admet-376	743	2	-	-	PUNCT
admet-376	743	3	mediated	mediate	VERB
admet-376	743	4	disposition	disposition	NOUN
admet-376	743	5	of	of	ADP
admet-376	743	6	opioids	opioid	NOUN
admet-376	743	7	:	:	PUNCT
admet-376	743	8	implications	implication	NOUN
admet-376	743	9	for	for	ADP
admet-376	743	10	clinical	clinical	ADJ
admet-376	743	11	drug	drug	NOUN
admet-376	743	12	interactions	interaction	NOUN
admet-376	743	13	,	,	PUNCT
admet-376	743	14	pharm	pharm	NOUN
admet-376	743	15	res	re	NOUN
admet-376	743	16	32	32	NUM
admet-376	743	17	(	(	PUNCT
admet-376	743	18	2015	2015	NUM
admet-376	743	19	)	)	PUNCT
admet-376	743	20	2477	2477	NUM
admet-376	743	21	-	-	SYM
admet-376	743	22	2502	2502	NUM
admet-376	743	23	.	.	PUNCT
admet-376	744	1	[	[	X
admet-376	744	2	219	219	NUM
admet-376	744	3	]	]	X
admet-376	744	4	j.d	j.d	PROPN
admet-376	744	5	.	.	PROPN
admet-376	744	6	bu'lock	bu'lock	PROPN
admet-376	744	7	.	.	PUNCT
admet-376	744	8	intermediary	intermediary	ADJ
admet-376	744	9	metabolism	metabolism	NOUN
admet-376	744	10	and	and	CCONJ
admet-376	744	11	antibiotic	antibiotic	ADJ
admet-376	744	12	synthesis	synthesis	NOUN
admet-376	744	13	.	.	PUNCT
admet-376	744	14	,	,	PUNCT
admet-376	744	15	adv	adv	PROPN
admet-376	744	16	.	.	PUNCT
admet-376	744	17	microbial	microbial	ADJ
admet-376	744	18	physiol	physiol	PROPN
admet-376	744	19	.	.	PUNCT
admet-376	745	1	3	3	NUM
admet-376	745	2	(	(	PUNCT
admet-376	745	3	1961	1961	NUM
admet-376	745	4	)	)	PUNCT
admet-376	745	5	293333	293333	NUM
admet-376	745	6	.	.	PUNCT
admet-376	746	1	[	[	X
admet-376	746	2	220	220	NUM
admet-376	746	3	]	]	SYM
admet-376	746	4	d.b	d.b	PROPN
admet-376	746	5	.	.	PROPN
admet-376	746	6	kell	kell	PROPN
admet-376	746	7	,	,	PUNCT
admet-376	746	8	a.s	a.s	PROPN
admet-376	746	9	.	.	PROPN
admet-376	746	10	kaprelyants	kaprelyant	NOUN
admet-376	746	11	,	,	PUNCT
admet-376	746	12	a.	a.	NOUN
admet-376	746	13	grafen	grafen	NOUN
admet-376	746	14	.	.	PUNCT
admet-376	747	1	on	on	ADP
admet-376	747	2	pheromones	pheromone	NOUN
admet-376	747	3	,	,	PUNCT
admet-376	747	4	social	social	ADJ
admet-376	747	5	behaviour	behaviour	NOUN
admet-376	747	6	and	and	CCONJ
admet-376	747	7	the	the	DET
admet-376	747	8	functions	function	NOUN
admet-376	747	9	of	of	ADP
admet-376	747	10	secondary	secondary	ADJ
admet-376	747	11	metabolism	metabolism	NOUN
admet-376	747	12	in	in	ADP
admet-376	747	13	bacteria	bacteria	NOUN
admet-376	747	14	,	,	PUNCT
admet-376	747	15	trends	trend	VERB
admet-376	747	16	ecol	ecol	PRON
admet-376	747	17	.	.	PUNCT
admet-376	748	1	evolution	evolution	NOUN
admet-376	748	2	10	10	NUM
admet-376	748	3	(	(	PUNCT
admet-376	748	4	1995	1995	NUM
admet-376	748	5	)	)	PUNCT
admet-376	748	6	126	126	NUM
admet-376	748	7	-	-	SYM
admet-376	748	8	129	129	NUM
admet-376	748	9	.	.	PUNCT
admet-376	749	1	[	[	X
admet-376	749	2	221	221	NUM
admet-376	749	3	]	]	X
admet-376	749	4	g.	g.	PROPN
admet-376	749	5	yim	yim	PROPN
admet-376	749	6	,	,	PUNCT
admet-376	749	7	h.h	h.h	PROPN
admet-376	749	8	.	.	PROPN
admet-376	749	9	wang	wang	PROPN
admet-376	749	10	,	,	PUNCT
admet-376	749	11	j.	j.	PROPN
admet-376	749	12	davies	davies	PROPN
admet-376	749	13	.	.	PUNCT
admet-376	750	1	the	the	DET
admet-376	750	2	truth	truth	NOUN
admet-376	750	3	about	about	ADP
admet-376	750	4	antibiotics	antibiotic	NOUN
admet-376	750	5	,	,	PUNCT
admet-376	750	6	int	int	PROPN
admet-376	750	7	j	j	PROPN
admet-376	750	8	med	med	PROPN
admet-376	750	9	microbiol	microbiol	NOUN
admet-376	750	10	296	296	NUM
admet-376	750	11	(	(	PUNCT
admet-376	750	12	2006	2006	NUM
admet-376	750	13	)	)	PUNCT
admet-376	750	14	163	163	NUM
admet-376	750	15	-	-	SYM
admet-376	750	16	170	170	NUM
admet-376	750	17	.	.	PUNCT
admet-376	751	1	[	[	X
admet-376	751	2	222	222	NUM
admet-376	751	3	]	]	X
admet-376	751	4	r.d	r.d	PROPN
admet-376	751	5	.	.	PROPN
admet-376	751	6	firn	firn	PROPN
admet-376	751	7	,	,	PUNCT
admet-376	751	8	c.g	c.g	PROPN
admet-376	751	9	.	.	PROPN
admet-376	751	10	jones	jones	PROPN
admet-376	751	11	.	.	PUNCT
admet-376	752	1	natural	natural	ADJ
admet-376	752	2	products	product	NOUN
admet-376	752	3	--	--	PUNCT
admet-376	752	4	a	a	DET
admet-376	752	5	simple	simple	ADJ
admet-376	752	6	model	model	NOUN
admet-376	752	7	to	to	PART
admet-376	752	8	explain	explain	VERB
admet-376	752	9	chemical	chemical	ADJ
admet-376	752	10	diversity	diversity	NOUN
admet-376	752	11	,	,	PUNCT
admet-376	752	12	nat	nat	PROPN
admet-376	752	13	prod	prod	PROPN
admet-376	752	14	rep	rep	PROPN
admet-376	752	15	20	20	NUM
admet-376	752	16	(	(	PUNCT
admet-376	752	17	2003	2003	NUM
admet-376	752	18	)	)	PUNCT
admet-376	752	19	382	382	NUM
admet-376	752	20	-	-	SYM
admet-376	752	21	391	391	NUM
admet-376	752	22	.	.	PUNCT
admet-376	753	1	[	[	X
admet-376	753	2	223	223	NUM
admet-376	753	3	]	]	PUNCT
admet-376	753	4	m.	m.	NOUN
admet-376	753	5	kimura	kimura	NOUN
admet-376	753	6	,	,	PUNCT
admet-376	753	7	the	the	DET
admet-376	753	8	neutral	neutral	ADJ
admet-376	753	9	theory	theory	NOUN
admet-376	753	10	of	of	ADP
admet-376	753	11	molecular	molecular	ADJ
admet-376	753	12	evolution	evolution	NOUN
admet-376	753	13	,	,	PUNCT
admet-376	753	14	cambridge	cambridge	PROPN
admet-376	753	15	university	university	PROPN
admet-376	753	16	press	press	PROPN
admet-376	753	17	,	,	PUNCT
admet-376	753	18	cambridge	cambridge	PROPN
admet-376	753	19	,	,	PUNCT
admet-376	753	20	1983	1983	NUM
admet-376	753	21	.	.	PUNCT
admet-376	754	1	[	[	X
admet-376	754	2	224	224	NUM
admet-376	754	3	]	]	PUNCT
admet-376	754	4	r.	r.	NOUN
admet-376	754	5	dawkins	dawkins	PROPN
admet-376	754	6	,	,	PUNCT
admet-376	754	7	the	the	DET
admet-376	754	8	selfish	selfish	ADJ
admet-376	754	9	gene	gene	NOUN
admet-376	754	10	:	:	PUNCT
admet-376	754	11	30th	30th	ADJ
admet-376	754	12	anniversary	anniversary	NOUN
admet-376	754	13	edition	edition	NOUN
admet-376	754	14	,	,	PUNCT
admet-376	754	15	oxford	oxford	PROPN
admet-376	754	16	university	university	PROPN
admet-376	754	17	press	press	NOUN
admet-376	754	18	,	,	PUNCT
admet-376	754	19	oxford	oxford	PROPN
admet-376	754	20	,	,	PUNCT
admet-376	754	21	2006	2006	NUM
admet-376	754	22	.	.	PUNCT
admet-376	755	1	[	[	X
admet-376	755	2	225	225	NUM
admet-376	755	3	]	]	X
admet-376	755	4	a.h	a.h	PROPN
admet-376	755	5	.	.	PROPN
admet-376	755	6	knoll	knoll	PROPN
admet-376	755	7	,	,	PUNCT
admet-376	755	8	e.j	e.j	PROPN
admet-376	755	9	.	.	PROPN
admet-376	755	10	javaux	javaux	PROPN
admet-376	755	11	,	,	PUNCT
admet-376	755	12	d.	d.	PROPN
admet-376	755	13	hewitt	hewitt	PROPN
admet-376	755	14	,	,	PUNCT
admet-376	755	15	p.	p.	PROPN
admet-376	755	16	cohen	cohen	PROPN
admet-376	755	17	.	.	PUNCT
admet-376	756	1	eukaryotic	eukaryotic	ADJ
admet-376	756	2	organisms	organism	NOUN
admet-376	756	3	in	in	ADP
admet-376	756	4	proterozoic	proterozoic	ADJ
admet-376	756	5	oceans	ocean	NOUN
admet-376	756	6	,	,	PUNCT
admet-376	756	7	philos	philo	VERB
admet-376	756	8	trans	trans	PROPN
admet-376	756	9	r	r	PROPN
admet-376	756	10	soc	soc	PROPN
admet-376	756	11	lond	lond	PROPN
admet-376	756	12	b	b	PROPN
admet-376	756	13	biol	biol	PROPN
admet-376	756	14	sci	sci	PROPN
admet-376	756	15	361	361	NUM
admet-376	756	16	(	(	PUNCT
admet-376	756	17	2006	2006	NUM
admet-376	756	18	)	)	PUNCT
admet-376	756	19	1023	1023	NUM
admet-376	756	20	-	-	SYM
admet-376	756	21	1038	1038	NUM
admet-376	756	22	.	.	PUNCT
admet-376	757	1	[	[	X
admet-376	757	2	226	226	NUM
admet-376	757	3	]	]	X
admet-376	757	4	a.h	a.h	PROPN
admet-376	757	5	.	.	PROPN
admet-376	757	6	knoll	knoll	PROPN
admet-376	757	7	.	.	PUNCT
admet-376	758	1	paleobiological	paleobiological	ADJ
admet-376	758	2	perspectives	perspective	NOUN
admet-376	758	3	on	on	ADP
admet-376	758	4	early	early	ADJ
admet-376	758	5	eukaryotic	eukaryotic	ADJ
admet-376	758	6	evolution	evolution	NOUN
admet-376	758	7	,	,	PUNCT
admet-376	758	8	cold	cold	ADJ
admet-376	758	9	spring	spring	NOUN
admet-376	758	10	harb	harb	PROPN
admet-376	758	11	perspect	perspect	VERB
admet-376	758	12	biol	biol	PROPN
admet-376	758	13	6	6	NUM
admet-376	758	14	(	(	PUNCT
admet-376	758	15	2014	2014	NUM
admet-376	758	16	)	)	PUNCT
admet-376	758	17	.	.	PUNCT
admet-376	759	1	admet	admet	PROPN
admet-376	759	2	&	&	CCONJ
admet-376	759	3	dmpk	dmpk	PROPN
admet-376	759	4	5(2	5(2	NUM
admet-376	759	5	)	)	PUNCT
admet-376	759	6	(	(	PUNCT
admet-376	759	7	2017	2017	NUM
admet-376	759	8	)	)	PUNCT
admet-376	759	9	85	85	NUM
admet-376	759	10	-	-	SYM
admet-376	759	11	125	125	NUM
admet-376	759	12	exogenous	exogenous	ADJ
admet-376	759	13	natural	natural	ADJ
admet-376	759	14	products	product	NOUN
admet-376	759	15	as	as	ADP
admet-376	759	16	‘	'	PUNCT
admet-376	759	17	natural	natural	ADJ
admet-376	759	18	’	'	PUNCT
admet-376	759	19	drug	drug	NOUN
admet-376	759	20	transporter	transporter	NOUN
admet-376	759	21	substrates	substrate	VERB
admet-376	759	22	doi	doi	NOUN
admet-376	759	23	:	:	PUNCT
admet-376	759	24	10.5599	10.5599	NUM
admet-376	759	25	/	/	SYM
admet-376	759	26	admet.5.2.376	admet.5.2.376	PROPN
admet-376	759	27	125	125	NUM
admet-376	759	28	[	[	X
admet-376	759	29	227	227	NUM
admet-376	759	30	]	]	X
admet-376	759	31	l.w	l.w	PROPN
admet-376	759	32	.	.	PROPN
admet-376	759	33	parfrey	parfrey	PROPN
admet-376	759	34	,	,	PUNCT
admet-376	759	35	d.j	d.j	PROPN
admet-376	759	36	.	.	PROPN
admet-376	759	37	lahr	lahr	PROPN
admet-376	759	38	,	,	PUNCT
admet-376	759	39	a.h	a.h	PROPN
admet-376	759	40	.	.	PROPN
admet-376	759	41	knoll	knoll	PROPN
admet-376	759	42	,	,	PUNCT
admet-376	759	43	l.a	l.a	PROPN
admet-376	759	44	.	.	PROPN
admet-376	759	45	katz	katz	PROPN
admet-376	759	46	.	.	PUNCT
admet-376	760	1	estimating	estimate	VERB
admet-376	760	2	the	the	DET
admet-376	760	3	timing	timing	NOUN
admet-376	760	4	of	of	ADP
admet-376	760	5	early	early	ADJ
admet-376	760	6	eukaryotic	eukaryotic	ADJ
admet-376	760	7	diversification	diversification	NOUN
admet-376	760	8	with	with	ADP
admet-376	760	9	multigene	multigene	ADJ
admet-376	760	10	molecular	molecular	ADJ
admet-376	760	11	clocks	clock	NOUN
admet-376	760	12	,	,	PUNCT
admet-376	760	13	proc	proc	PROPN
admet-376	760	14	natl	natl	PROPN
admet-376	760	15	acad	acad	PROPN
admet-376	760	16	sci	sci	PROPN
admet-376	760	17	u	u	PROPN
admet-376	760	18	s	s	PROPN
admet-376	760	19	a	a	DET
admet-376	760	20	108	108	NUM
admet-376	760	21	(	(	PUNCT
admet-376	760	22	2011	2011	NUM
admet-376	760	23	)	)	PUNCT
admet-376	760	24	13624	13624	NUM
admet-376	760	25	-	-	SYM
admet-376	760	26	13629	13629	NUM
admet-376	760	27	.	.	PUNCT
admet-376	761	1	[	[	X
admet-376	761	2	228	228	NUM
admet-376	761	3	]	]	PUNCT
admet-376	761	4	p.	p.	NOUN
admet-376	761	5	wilf	wilf	PROPN
admet-376	761	6	,	,	PUNCT
admet-376	761	7	m.r	m.r	PROPN
admet-376	761	8	.	.	PROPN
admet-376	761	9	carvalho	carvalho	PROPN
admet-376	761	10	,	,	PUNCT
admet-376	761	11	m.a	m.a	PROPN
admet-376	761	12	.	.	PROPN
admet-376	761	13	gandolfo	gandolfo	PROPN
admet-376	761	14	,	,	PUNCT
admet-376	761	15	n.r	n.r	PROPN
admet-376	761	16	.	.	PROPN
admet-376	761	17	cúneo	cúneo	PROPN
admet-376	761	18	.	.	PUNCT
admet-376	762	1	eocene	eocene	PROPN
admet-376	762	2	lantern	lantern	ADJ
admet-376	762	3	fruits	fruit	NOUN
admet-376	762	4	from	from	ADP
admet-376	762	5	gondwanan	gondwanan	PROPN
admet-376	762	6	patagonia	patagonia	PROPN
admet-376	762	7	and	and	CCONJ
admet-376	762	8	the	the	DET
admet-376	762	9	early	early	ADJ
admet-376	762	10	origins	origin	NOUN
admet-376	762	11	of	of	ADP
admet-376	762	12	solanaceae	solanaceae	PROPN
admet-376	762	13	,	,	PUNCT
admet-376	762	14	science	science	NOUN
admet-376	762	15	355	355	NUM
admet-376	762	16	(	(	PUNCT
admet-376	762	17	2017	2017	NUM
admet-376	762	18	)	)	PUNCT
admet-376	762	19	71	71	NUM
admet-376	762	20	-	-	SYM
admet-376	762	21	75	75	NUM
admet-376	762	22	.	.	PUNCT
admet-376	763	1	[	[	X
admet-376	763	2	229	229	NUM
admet-376	763	3	]	]	X
admet-376	763	4	e.	e.	PROPN
admet-376	763	5	perland	perland	PROPN
admet-376	763	6	,	,	PUNCT
admet-376	763	7	r.	r.	PROPN
admet-376	763	8	fredriksson	fredriksson	PROPN
admet-376	763	9	.	.	PUNCT
admet-376	764	1	classification	classification	NOUN
admet-376	764	2	systems	system	NOUN
admet-376	764	3	of	of	ADP
admet-376	764	4	secondary	secondary	ADJ
admet-376	764	5	active	active	ADJ
admet-376	764	6	transporters	transporter	NOUN
admet-376	764	7	,	,	PUNCT
admet-376	764	8	trends	trend	NOUN
admet-376	764	9	pharmacol	pharmacol	VERB
admet-376	764	10	sci	sci	PROPN
admet-376	764	11	38	38	NUM
admet-376	764	12	(	(	PUNCT
admet-376	764	13	2017	2017	NUM
admet-376	764	14	)	)	PUNCT
admet-376	764	15	305	305	NUM
admet-376	764	16	-	-	SYM
admet-376	764	17	315	315	NUM
admet-376	764	18	.	.	PUNCT
admet-376	765	1	[	[	X
admet-376	765	2	230	230	NUM
admet-376	765	3	]	]	X
admet-376	765	4	m.h	m.h	PROPN
admet-376	765	5	.	.	PROPN
admet-376	765	6	saier	saier	PROPN
admet-376	765	7	,	,	PUNCT
admet-376	765	8	jr	jr	PROPN
admet-376	765	9	.	.	PROPN
admet-376	765	10	,	,	PUNCT
admet-376	765	11	v.s.	v.s.	PROPN
admet-376	765	12	reddy	reddy	PROPN
admet-376	765	13	,	,	PUNCT
admet-376	765	14	b.v	b.v	PROPN
admet-376	765	15	.	.	PROPN
admet-376	765	16	tsu	tsu	PROPN
admet-376	765	17	,	,	PUNCT
admet-376	765	18	m.s	m.s	PROPN
admet-376	765	19	.	.	PROPN
admet-376	765	20	ahmed	ahmed	PROPN
admet-376	765	21	,	,	PUNCT
admet-376	765	22	c.	c.	PROPN
admet-376	765	23	li	li	PROPN
admet-376	765	24	,	,	PUNCT
admet-376	765	25	g.	g.	PROPN
admet-376	765	26	moreno	moreno	PROPN
admet-376	765	27	-	-	PUNCT
admet-376	765	28	hagelsieb	hagelsieb	PROPN
admet-376	765	29	.	.	PUNCT
admet-376	766	1	the	the	DET
admet-376	766	2	transporter	transporter	NOUN
admet-376	766	3	classification	classification	NOUN
admet-376	766	4	database	database	NOUN
admet-376	766	5	(	(	PUNCT
admet-376	766	6	tcdb	tcdb	NOUN
admet-376	766	7	):	):	PUNCT
admet-376	766	8	recent	recent	ADJ
admet-376	766	9	advances	advance	NOUN
admet-376	766	10	,	,	PUNCT
admet-376	766	11	nucleic	nucleic	ADJ
admet-376	766	12	acids	acid	NOUN
admet-376	766	13	res	re	NOUN
admet-376	766	14	44	44	NUM
admet-376	766	15	(	(	PUNCT
admet-376	766	16	2016	2016	NUM
admet-376	766	17	)	)	PUNCT
admet-376	766	18	d372	d372	PROPN
admet-376	766	19	-	-	SYM
admet-376	766	20	379	379	NUM
admet-376	766	21	.	.	PUNCT
admet-376	767	1	[	[	X
admet-376	767	2	231	231	NUM
admet-376	767	3	]	]	SYM
admet-376	767	4	d.c	d.c	PROPN
admet-376	767	5	.	.	PUNCT
admet-376	767	6	rees	rees	PROPN
admet-376	767	7	,	,	PUNCT
admet-376	767	8	e.	e.	PROPN
admet-376	767	9	johnson	johnson	PROPN
admet-376	767	10	,	,	PUNCT
admet-376	767	11	o.	o.	PROPN
admet-376	767	12	lewinson	lewinson	PROPN
admet-376	767	13	.	.	PUNCT
admet-376	768	1	abc	abc	PROPN
admet-376	768	2	transporters	transporter	NOUN
admet-376	768	3	:	:	PUNCT
admet-376	768	4	the	the	DET
admet-376	768	5	power	power	NOUN
admet-376	768	6	to	to	PART
admet-376	768	7	change	change	VERB
admet-376	768	8	,	,	PUNCT
admet-376	768	9	nat	nat	PROPN
admet-376	768	10	rev	rev	VERB
admet-376	768	11	mol	mol	ADP
admet-376	768	12	cell	cell	NOUN
admet-376	768	13	biol	biol	NOUN
admet-376	768	14	10	10	NUM
admet-376	768	15	(	(	PUNCT
admet-376	768	16	2009	2009	NUM
admet-376	768	17	)	)	PUNCT
admet-376	768	18	218	218	NUM
admet-376	768	19	-	-	SYM
admet-376	768	20	227	227	NUM
admet-376	768	21	.	.	PUNCT
admet-376	769	1	[	[	X
admet-376	769	2	232	232	X
admet-376	769	3	]	]	X
admet-376	769	4	l.n	l.n	PROPN
admet-376	769	5	.	.	PROPN
admet-376	769	6	eadie	eadie	PROPN
admet-376	769	7	,	,	PUNCT
admet-376	769	8	t.p	t.p	PROPN
admet-376	769	9	.	.	PROPN
admet-376	769	10	hughes	hughes	PROPN
admet-376	769	11	,	,	PUNCT
admet-376	769	12	d.l	d.l	PROPN
admet-376	769	13	.	.	PROPN
admet-376	769	14	white	white	PROPN
admet-376	769	15	.	.	PUNCT
admet-376	770	1	interaction	interaction	NOUN
admet-376	770	2	of	of	ADP
admet-376	770	3	the	the	DET
admet-376	770	4	efflux	efflux	ADJ
admet-376	770	5	transporters	transporter	NOUN
admet-376	770	6	abcb1	abcb1	NOUN
admet-376	770	7	and	and	CCONJ
admet-376	770	8	abcg2	abcg2	NOUN
admet-376	770	9	with	with	ADP
admet-376	770	10	imatinib	imatinib	NOUN
admet-376	770	11	,	,	PUNCT
admet-376	770	12	nilotinib	nilotinib	NOUN
admet-376	770	13	,	,	PUNCT
admet-376	770	14	and	and	CCONJ
admet-376	770	15	dasatinib	dasatinib	NOUN
admet-376	770	16	,	,	PUNCT
admet-376	770	17	clin	clin	PROPN
admet-376	770	18	pharmacol	pharmacol	PROPN
admet-376	770	19	ther	ther	ADV
admet-376	770	20	95	95	NUM
admet-376	770	21	(	(	PUNCT
admet-376	770	22	2014	2014	NUM
admet-376	770	23	)	)	PUNCT
admet-376	770	24	294	294	NUM
admet-376	770	25	-	-	SYM
admet-376	770	26	306	306	NUM
admet-376	770	27	.	.	PUNCT
admet-376	771	1	[	[	X
admet-376	771	2	233	233	NUM
admet-376	771	3	]	]	PUNCT
admet-376	771	4	f.	f.	PROPN
admet-376	771	5	montanari	montanari	PROPN
admet-376	771	6	,	,	PUNCT
admet-376	771	7	g.f	g.f	PROPN
admet-376	771	8	.	.	PROPN
admet-376	771	9	ecker	ecker	PROPN
admet-376	771	10	.	.	PUNCT
admet-376	771	11	prediction	prediction	NOUN
admet-376	771	12	of	of	ADP
admet-376	771	13	drug	drug	NOUN
admet-376	771	14	-	-	PUNCT
admet-376	771	15	abc	abc	PROPN
admet-376	771	16	transporter	transporter	NOUN
admet-376	771	17	interaction	interaction	NOUN
admet-376	771	18	recent	recent	ADJ
admet-376	771	19	advances	advance	NOUN
admet-376	771	20	and	and	CCONJ
admet-376	771	21	future	future	ADJ
admet-376	771	22	challenges	challenge	NOUN
admet-376	771	23	,	,	PUNCT
admet-376	771	24	adv	adv	PROPN
admet-376	771	25	drug	drug	NOUN
admet-376	771	26	deliv	deliv	NOUN
admet-376	771	27	rev	rev	X
admet-376	771	28	(	(	PUNCT
admet-376	771	29	2015	2015	NUM
admet-376	771	30	)	)	PUNCT
admet-376	771	31	.	.	PUNCT
admet-376	772	1	[	[	X
admet-376	772	2	234	234	NUM
admet-376	772	3	]	]	PUNCT
admet-376	772	4	z.	z.	PROPN
admet-376	772	5	chen	chen	PROPN
admet-376	772	6	,	,	PUNCT
admet-376	772	7	t.	t.	PROPN
admet-376	772	8	shi	shi	PROPN
admet-376	772	9	,	,	PUNCT
admet-376	772	10	l.	l.	PROPN
admet-376	772	11	zhang	zhang	PROPN
admet-376	772	12	,	,	PUNCT
admet-376	772	13	p.	p.	PROPN
admet-376	772	14	zhu	zhu	PROPN
admet-376	772	15	,	,	PUNCT
admet-376	772	16	m.	m.	PROPN
admet-376	772	17	deng	deng	PROPN
admet-376	772	18	,	,	PUNCT
admet-376	772	19	c.	c.	PROPN
admet-376	772	20	huang	huang	PROPN
admet-376	772	21	,	,	PUNCT
admet-376	772	22	t.	t.	PROPN
admet-376	772	23	hu	hu	PROPN
admet-376	772	24	,	,	PUNCT
admet-376	772	25	l.	l.	PROPN
admet-376	772	26	jiang	jiang	PROPN
admet-376	772	27	,	,	PUNCT
admet-376	772	28	j.	j.	PROPN
admet-376	772	29	li	li	PROPN
admet-376	772	30	.	.	PROPN
admet-376	773	1	mammalian	mammalian	ADJ
admet-376	773	2	drug	drug	NOUN
admet-376	773	3	efflux	efflux	VERB
admet-376	773	4	transporters	transporter	NOUN
admet-376	773	5	of	of	ADP
admet-376	773	6	the	the	DET
admet-376	773	7	atp	atp	NOUN
admet-376	773	8	binding	bind	VERB
admet-376	773	9	cassette	cassette	NOUN
admet-376	773	10	(	(	PUNCT
admet-376	773	11	abc	abc	PROPN
admet-376	773	12	)	)	PUNCT
admet-376	773	13	family	family	NOUN
admet-376	773	14	in	in	ADP
admet-376	773	15	multidrug	multidrug	NOUN
admet-376	773	16	resistance	resistance	NOUN
admet-376	773	17	:	:	PUNCT
admet-376	773	18	a	a	DET
admet-376	773	19	review	review	NOUN
admet-376	773	20	of	of	ADP
admet-376	773	21	the	the	DET
admet-376	773	22	past	past	ADJ
admet-376	773	23	decade	decade	NOUN
admet-376	773	24	,	,	PUNCT
admet-376	773	25	cancer	cancer	NOUN
admet-376	773	26	lett	lett	NOUN
admet-376	773	27	370	370	NUM
admet-376	773	28	(	(	PUNCT
admet-376	773	29	2016	2016	NUM
admet-376	773	30	)	)	PUNCT
admet-376	773	31	153	153	NUM
admet-376	773	32	-	-	SYM
admet-376	773	33	164	164	NUM
admet-376	773	34	.	.	PUNCT
admet-376	774	1	[	[	X
admet-376	774	2	235	235	NUM
admet-376	774	3	]	]	PUNCT
admet-376	774	4	m.	m.	NOUN
admet-376	774	5	uhlén	uhlén	PROPN
admet-376	774	6	,	,	PUNCT
admet-376	774	7	l.	l.	PROPN
admet-376	774	8	fagerberg	fagerberg	PROPN
admet-376	774	9	,	,	PUNCT
admet-376	774	10	b.m	b.m	PROPN
admet-376	774	11	.	.	PROPN
admet-376	774	12	hallstrom	hallstrom	PROPN
admet-376	774	13	,	,	PUNCT
admet-376	774	14	c.	c.	PROPN
admet-376	774	15	lindskog	lindskog	PROPN
admet-376	774	16	,	,	PUNCT
admet-376	774	17	p.	p.	NOUN
admet-376	774	18	oksvold	oksvold	NOUN
admet-376	774	19	,	,	PUNCT
admet-376	774	20	a.	a.	NOUN
admet-376	774	21	mardinoglu	mardinoglu	PROPN
admet-376	774	22	,	,	PUNCT
admet-376	774	23	ǻ	ǻ	PROPN
admet-376	774	24	.	.	PUNCT
admet-376	774	25	sivertsson	sivertsson	PROPN
admet-376	774	26	,	,	PUNCT
admet-376	774	27	c.	c.	PROPN
admet-376	774	28	kampf	kampf	PROPN
admet-376	774	29	,	,	PUNCT
admet-376	774	30	e.	e.	PROPN
admet-376	774	31	sjöstedt	sjöstedt	PROPN
admet-376	774	32	,	,	PUNCT
admet-376	774	33	a.	a.	NOUN
admet-376	774	34	asplund	asplund	PROPN
admet-376	774	35	,	,	PUNCT
admet-376	774	36	i.	i.	PROPN
admet-376	774	37	olsson	olsson	PROPN
admet-376	774	38	,	,	PUNCT
admet-376	774	39	k.	k.	PROPN
admet-376	774	40	edlund	edlund	PROPN
admet-376	774	41	,	,	PUNCT
admet-376	774	42	e.	e.	PROPN
admet-376	774	43	lundberg	lundberg	PROPN
admet-376	774	44	,	,	PUNCT
admet-376	774	45	s.	s.	PROPN
admet-376	774	46	navani	navani	PROPN
admet-376	774	47	,	,	PUNCT
admet-376	774	48	c.a	c.a	PROPN
admet-376	774	49	.	.	PROPN
admet-376	774	50	szigyarto	szigyarto	PROPN
admet-376	774	51	,	,	PUNCT
admet-376	774	52	j.	j.	PROPN
admet-376	774	53	odeberg	odeberg	PROPN
admet-376	774	54	,	,	PUNCT
admet-376	774	55	d.	d.	PROPN
admet-376	774	56	djureinovic	djureinovic	PROPN
admet-376	774	57	,	,	PUNCT
admet-376	774	58	j.o	j.o	PROPN
admet-376	774	59	.	.	PROPN
admet-376	774	60	takanen	takanen	PROPN
admet-376	774	61	,	,	PUNCT
admet-376	774	62	s.	s.	PROPN
admet-376	774	63	hober	hober	PROPN
admet-376	774	64	,	,	PUNCT
admet-376	774	65	t.	t.	PROPN
admet-376	774	66	alm	alm	PROPN
admet-376	774	67	,	,	PUNCT
admet-376	774	68	p.h	p.h	PROPN
admet-376	774	69	.	.	PROPN
admet-376	774	70	edqvist	edqvist	PROPN
admet-376	774	71	,	,	PUNCT
admet-376	774	72	h.	h.	PROPN
admet-376	774	73	berling	berling	PROPN
admet-376	774	74	,	,	PUNCT
admet-376	774	75	h.	h.	PROPN
admet-376	774	76	tegel	tegel	PROPN
admet-376	774	77	,	,	PUNCT
admet-376	774	78	j.	j.	PROPN
admet-376	774	79	mulder	mulder	PROPN
admet-376	774	80	,	,	PUNCT
admet-376	774	81	j.	j.	PROPN
admet-376	774	82	rockberg	rockberg	PROPN
admet-376	774	83	,	,	PUNCT
admet-376	775	1	p.	p.	PROPN
admet-376	775	2	nilsson	nilsson	PROPN
admet-376	775	3	,	,	PUNCT
admet-376	775	4	j.m	j.m	PROPN
admet-376	775	5	.	.	PROPN
admet-376	775	6	schwenk	schwenk	PROPN
admet-376	775	7	,	,	PUNCT
admet-376	775	8	m.	m.	NOUN
admet-376	775	9	hamsten	hamsten	PROPN
admet-376	775	10	,	,	PUNCT
admet-376	775	11	k.	k.	PROPN
admet-376	775	12	von	von	PROPN
admet-376	775	13	feilitzen	feilitzen	PROPN
admet-376	775	14	,	,	PUNCT
admet-376	775	15	m.	m.	NOUN
admet-376	775	16	forsberg	forsberg	PROPN
admet-376	775	17	,	,	PUNCT
admet-376	775	18	l.	l.	PROPN
admet-376	775	19	persson	persson	PROPN
admet-376	775	20	,	,	PUNCT
admet-376	775	21	f.	f.	PROPN
admet-376	775	22	johansson	johansson	PROPN
admet-376	775	23	,	,	PUNCT
admet-376	775	24	m.	m.	NOUN
admet-376	775	25	zwahlen	zwahlen	PROPN
admet-376	775	26	,	,	PUNCT
admet-376	775	27	g.	g.	PROPN
admet-376	775	28	von	von	PROPN
admet-376	775	29	heijne	heijne	PROPN
admet-376	775	30	,	,	PUNCT
admet-376	775	31	j.	j.	PROPN
admet-376	775	32	nielsen	nielsen	PROPN
admet-376	775	33	,	,	PUNCT
admet-376	775	34	f.	f.	PROPN
admet-376	775	35	pontén	pontén	PROPN
admet-376	775	36	.	.	PUNCT
admet-376	776	1	tissue	tissue	NOUN
admet-376	776	2	-	-	PUNCT
admet-376	776	3	based	base	VERB
admet-376	776	4	map	map	NOUN
admet-376	776	5	of	of	ADP
admet-376	776	6	the	the	DET
admet-376	776	7	human	human	ADJ
admet-376	776	8	proteome	proteome	NOUN
admet-376	776	9	,	,	PUNCT
admet-376	776	10	science	science	NOUN
admet-376	776	11	347	347	NUM
admet-376	776	12	(	(	PUNCT
admet-376	776	13	2015	2015	NUM
admet-376	776	14	)	)	PUNCT
admet-376	776	15	1260419	1260419	NUM
admet-376	776	16	.	.	PUNCT
admet-376	777	1	[	[	X
admet-376	777	2	236	236	NUM
admet-376	777	3	]	]	X
admet-376	777	4	p.j	p.j	PROPN
admet-376	777	5	.	.	PROPN
admet-376	777	6	thul	thul	PROPN
admet-376	777	7	,	,	PUNCT
admet-376	777	8	l.	l.	PROPN
admet-376	777	9	åkesson	åkesson	PROPN
admet-376	777	10	,	,	PUNCT
admet-376	777	11	m.	m.	NOUN
admet-376	777	12	wiking	wiking	PROPN
admet-376	777	13	,	,	PUNCT
admet-376	777	14	d.	d.	PROPN
admet-376	777	15	mahdessian	mahdessian	PROPN
admet-376	777	16	,	,	PUNCT
admet-376	777	17	a.	a.	NOUN
admet-376	777	18	geladaki	geladaki	NOUN
admet-376	777	19	,	,	PUNCT
admet-376	777	20	h.	h.	PROPN
admet-376	777	21	ait	ait	PROPN
admet-376	777	22	blal	blal	PROPN
admet-376	777	23	,	,	PUNCT
admet-376	777	24	t.	t.	PROPN
admet-376	777	25	alm	alm	PROPN
admet-376	777	26	,	,	PUNCT
admet-376	777	27	a.	a.	NOUN
admet-376	777	28	asplund	asplund	PROPN
admet-376	777	29	,	,	PUNCT
admet-376	777	30	l.	l.	PROPN
admet-376	777	31	björk	björk	PROPN
admet-376	777	32	,	,	PUNCT
admet-376	777	33	l.m	l.m	PROPN
admet-376	777	34	.	.	PROPN
admet-376	777	35	breckels	breckel	NOUN
admet-376	777	36	,	,	PUNCT
admet-376	777	37	a.	a.	NOUN
admet-376	777	38	bäckström	bäckström	NOUN
admet-376	777	39	,	,	PUNCT
admet-376	777	40	f.	f.	PROPN
admet-376	777	41	danielsson	danielsson	PROPN
admet-376	777	42	,	,	PUNCT
admet-376	777	43	l.	l.	PROPN
admet-376	777	44	fagerberg	fagerberg	PROPN
admet-376	777	45	,	,	PUNCT
admet-376	777	46	j.	j.	PROPN
admet-376	777	47	fall	fall	PROPN
admet-376	777	48	,	,	PUNCT
admet-376	777	49	l.	l.	PROPN
admet-376	777	50	gatto	gatto	PROPN
admet-376	777	51	,	,	PUNCT
admet-376	777	52	c.	c.	PROPN
admet-376	777	53	gnann	gnann	PROPN
admet-376	777	54	,	,	PUNCT
admet-376	777	55	s.	s.	PROPN
admet-376	777	56	hober	hober	PROPN
admet-376	777	57	,	,	PUNCT
admet-376	777	58	m.	m.	PROPN
admet-376	777	59	hjelmare	hjelmare	PROPN
admet-376	777	60	,	,	PUNCT
admet-376	777	61	f.	f.	PROPN
admet-376	777	62	johansson	johansson	PROPN
admet-376	777	63	,	,	PUNCT
admet-376	777	64	s.	s.	PROPN
admet-376	777	65	lee	lee	PROPN
admet-376	777	66	,	,	PUNCT
admet-376	777	67	c.	c.	PROPN
admet-376	777	68	lindskog	lindskog	PROPN
admet-376	777	69	,	,	PUNCT
admet-376	777	70	j.	j.	PROPN
admet-376	777	71	mulder	mulder	PROPN
admet-376	777	72	,	,	PUNCT
admet-376	777	73	c.m	c.m	PROPN
admet-376	777	74	.	.	PROPN
admet-376	777	75	mulvey	mulvey	PROPN
admet-376	777	76	,	,	PUNCT
admet-376	777	77	p.	p.	PROPN
admet-376	777	78	nilsson	nilsson	PROPN
admet-376	777	79	,	,	PUNCT
admet-376	777	80	p.	p.	PROPN
admet-376	777	81	oksvold	oksvold	NOUN
admet-376	777	82	,	,	PUNCT
admet-376	777	83	j.	j.	PROPN
admet-376	777	84	rockberg	rockberg	PROPN
admet-376	777	85	,	,	PUNCT
admet-376	777	86	r.	r.	PROPN
admet-376	777	87	schutten	schutten	PROPN
admet-376	777	88	,	,	PUNCT
admet-376	777	89	j.m	j.m	PROPN
admet-376	777	90	.	.	PROPN
admet-376	777	91	schwenk	schwenk	PROPN
admet-376	777	92	,	,	PUNCT
admet-376	777	93	å	å	PROPN
admet-376	777	94	.	.	PUNCT
admet-376	777	95	sivertsson	sivertsson	PROPN
admet-376	777	96	,	,	PUNCT
admet-376	777	97	e.	e.	PROPN
admet-376	777	98	sjöstedt	sjöstedt	PROPN
admet-376	777	99	,	,	PUNCT
admet-376	777	100	m.	m.	NOUN
admet-376	777	101	skogs	skog	NOUN
admet-376	777	102	,	,	PUNCT
admet-376	777	103	c.	c.	PROPN
admet-376	777	104	stadler	stadler	PROPN
admet-376	777	105	,	,	PUNCT
admet-376	777	106	d.p	d.p	PROPN
admet-376	777	107	.	.	PROPN
admet-376	777	108	sullivan	sullivan	PROPN
admet-376	777	109	,	,	PUNCT
admet-376	777	110	h.	h.	PROPN
admet-376	777	111	tegel	tegel	PROPN
admet-376	777	112	,	,	PUNCT
admet-376	777	113	c.	c.	PROPN
admet-376	777	114	winsnes	winsnes	PROPN
admet-376	777	115	,	,	PUNCT
admet-376	777	116	c.	c.	PROPN
admet-376	777	117	zhang	zhang	PROPN
admet-376	777	118	,	,	PUNCT
admet-376	777	119	m.	m.	NOUN
admet-376	777	120	zwahlen	zwahlen	PROPN
admet-376	777	121	,	,	PUNCT
admet-376	777	122	a.	a.	NOUN
admet-376	777	123	mardinoglu	mardinoglu	PROPN
admet-376	777	124	,	,	PUNCT
admet-376	777	125	f.	f.	PROPN
admet-376	777	126	pontén	pontén	PROPN
admet-376	777	127	,	,	PUNCT
admet-376	777	128	k.	k.	PROPN
admet-376	777	129	von	von	PROPN
admet-376	777	130	feilitzen	feilitzen	PROPN
admet-376	777	131	,	,	PUNCT
admet-376	777	132	k.s	k.s	PROPN
admet-376	777	133	.	.	PROPN
admet-376	777	134	lilley	lilley	PROPN
admet-376	777	135	,	,	PUNCT
admet-376	777	136	m.	m.	NOUN
admet-376	777	137	uhlén	uhlén	PROPN
admet-376	777	138	,	,	PUNCT
admet-376	777	139	e.	e.	PROPN
admet-376	777	140	lundberg	lundberg	PROPN
admet-376	777	141	.	.	PUNCT
admet-376	778	1	a	a	DET
admet-376	778	2	subcellular	subcellular	ADJ
admet-376	778	3	map	map	NOUN
admet-376	778	4	of	of	ADP
admet-376	778	5	the	the	DET
admet-376	778	6	human	human	ADJ
admet-376	778	7	proteome	proteome	NOUN
admet-376	778	8	,	,	PUNCT
admet-376	778	9	science	science	NOUN
admet-376	778	10	356	356	NUM
admet-376	778	11	(	(	PUNCT
admet-376	778	12	2017	2017	NUM
admet-376	778	13	)	)	PUNCT
admet-376	778	14	.	.	PUNCT
admet-376	779	1	[	[	X
admet-376	779	2	237	237	NUM
admet-376	779	3	]	]	PUNCT
admet-376	779	4	m.	m.	NOUN
admet-376	779	5	lahlou	lahlou	PROPN
admet-376	779	6	.	.	PUNCT
admet-376	780	1	the	the	DET
admet-376	780	2	success	success	NOUN
admet-376	780	3	of	of	ADP
admet-376	780	4	natural	natural	ADJ
admet-376	780	5	products	product	NOUN
admet-376	780	6	in	in	ADP
admet-376	780	7	drug	drug	NOUN
admet-376	780	8	discovery	discovery	NOUN
admet-376	780	9	,	,	PUNCT
admet-376	780	10	pharmacol	pharmacol	NOUN
admet-376	780	11	pharm	pharm	NOUN
admet-376	780	12	4	4	NUM
admet-376	780	13	(	(	PUNCT
admet-376	780	14	2013	2013	NUM
admet-376	780	15	)	)	PUNCT
admet-376	780	16	17	17	NUM
admet-376	780	17	-	-	SYM
admet-376	780	18	31	31	NUM
admet-376	780	19	.	.	PUNCT
admet-376	781	1	[	[	X
admet-376	781	2	238	238	NUM
admet-376	781	3	]	]	X
admet-376	781	4	j.w.-h	j.w.-h	PROPN
admet-376	781	5	.	.	PUNCT
admet-376	782	1	li	li	PROPN
admet-376	782	2	,	,	PUNCT
admet-376	782	3	j.c	j.c	PROPN
admet-376	782	4	.	.	PROPN
admet-376	782	5	vederas	vederas	PROPN
admet-376	782	6	.	.	PUNCT
admet-376	782	7	drug	drug	NOUN
admet-376	782	8	discovery	discovery	PROPN
admet-376	782	9	and	and	CCONJ
admet-376	782	10	natural	natural	ADJ
admet-376	782	11	products	product	NOUN
admet-376	782	12	:	:	PUNCT
admet-376	782	13	end	end	NOUN
admet-376	782	14	of	of	ADP
admet-376	782	15	an	an	DET
admet-376	782	16	era	era	NOUN
admet-376	782	17	or	or	CCONJ
admet-376	782	18	an	an	DET
admet-376	782	19	endless	endless	ADJ
admet-376	782	20	frontier	frontier	NOUN
admet-376	782	21	?	?	PUNCT
admet-376	782	22	,	,	PUNCT
admet-376	782	23	science	science	NOUN
admet-376	782	24	325	325	NUM
admet-376	782	25	(	(	PUNCT
admet-376	782	26	2009	2009	NUM
admet-376	782	27	)	)	PUNCT
admet-376	782	28	161	161	NUM
admet-376	782	29	-	-	SYM
admet-376	782	30	165	165	NUM
admet-376	782	31	.	.	PUNCT
admet-376	783	1	[	[	X
admet-376	783	2	239	239	NUM
admet-376	783	3	]	]	X
admet-376	783	4	g.	g.	PROPN
admet-376	783	5	molinari	molinari	PROPN
admet-376	783	6	.	.	PUNCT
admet-376	783	7	natural	natural	ADJ
admet-376	783	8	products	product	NOUN
admet-376	783	9	in	in	ADP
admet-376	783	10	drug	drug	NOUN
admet-376	783	11	discovery	discovery	NOUN
admet-376	783	12	:	:	PUNCT
admet-376	783	13	present	present	ADJ
admet-376	783	14	status	status	NOUN
admet-376	783	15	and	and	CCONJ
admet-376	783	16	perspectives	perspective	NOUN
admet-376	783	17	,	,	PUNCT
admet-376	783	18	adv	adv	PROPN
admet-376	783	19	exp	exp	NOUN
admet-376	783	20	med	med	ADJ
admet-376	783	21	biol	biol	NOUN
admet-376	783	22	655	655	NUM
admet-376	783	23	(	(	PUNCT
admet-376	783	24	2009	2009	NUM
admet-376	783	25	)	)	PUNCT
admet-376	783	26	13	13	NUM
admet-376	783	27	-	-	SYM
admet-376	783	28	27	27	NUM
admet-376	783	29	.	.	PUNCT
admet-376	784	1	[	[	X
admet-376	784	2	240	240	NUM
admet-376	784	3	]	]	X
admet-376	784	4	e.f	e.f	PROPN
admet-376	784	5	.	.	PROPN
admet-376	784	6	van	van	PROPN
admet-376	784	7	herwerden	herwerden	PROPN
admet-376	784	8	,	,	PUNCT
admet-376	784	9	r.d	r.d	PROPN
admet-376	784	10	.	.	PROPN
admet-376	784	11	süssmuth	süssmuth	NOUN
admet-376	784	12	.	.	PUNCT
admet-376	785	1	sources	source	NOUN
admet-376	785	2	for	for	ADP
admet-376	785	3	leads	lead	NOUN
admet-376	785	4	:	:	PUNCT
admet-376	785	5	natural	natural	ADJ
admet-376	785	6	products	product	NOUN
admet-376	785	7	and	and	CCONJ
admet-376	785	8	libraries	library	NOUN
admet-376	785	9	,	,	PUNCT
admet-376	785	10	handb	handb	VERB
admet-376	785	11	exp	exp	NOUN
admet-376	785	12	pharmacol	pharmacol	PROPN
admet-376	785	13	232	232	NUM
admet-376	785	14	(	(	PUNCT
admet-376	785	15	2016	2016	NUM
admet-376	785	16	)	)	PUNCT
admet-376	785	17	91	91	NUM
admet-376	785	18	-	-	SYM
admet-376	785	19	123	123	NUM
admet-376	785	20	.	.	PUNCT
admet-376	786	1	[	[	X
admet-376	786	2	241	241	X
admet-376	786	3	]	]	X
admet-376	786	4	b.s	b.s	PROPN
admet-376	786	5	.	.	PROPN
admet-376	786	6	everitt	everitt	PROPN
admet-376	786	7	,	,	PUNCT
admet-376	786	8	cluster	cluster	NOUN
admet-376	786	9	analysis	analysis	NOUN
admet-376	786	10	,	,	PUNCT
admet-376	786	11	edward	edward	PROPN
admet-376	786	12	arnold	arnold	PROPN
admet-376	786	13	,	,	PUNCT
admet-376	786	14	london	london	PROPN
admet-376	786	15	,	,	PUNCT
admet-376	786	16	1993	1993	NUM
admet-376	786	17	.	.	PUNCT
admet-376	787	1	©	©	PROPN
admet-376	787	2	2017	2017	NUM
admet-376	787	3	by	by	ADP
admet-376	787	4	the	the	DET
admet-376	787	5	authors	author	NOUN
admet-376	787	6	;	;	PUNCT
admet-376	787	7	licensee	licensee	PROPN
admet-376	787	8	iapc	iapc	PROPN
admet-376	787	9	,	,	PUNCT
admet-376	787	10	zagreb	zagreb	PROPN
admet-376	787	11	,	,	PUNCT
admet-376	787	12	croatia	croatia	PROPN
admet-376	787	13	.	.	PUNCT
admet-376	788	1	this	this	DET
admet-376	788	2	article	article	NOUN
admet-376	788	3	is	be	AUX
admet-376	788	4	an	an	DET
admet-376	788	5	open	open	ADJ
admet-376	788	6	-	-	PUNCT
admet-376	788	7	access	access	NOUN
admet-376	788	8	article	article	NOUN
admet-376	788	9	distributed	distribute	VERB
admet-376	788	10	under	under	ADP
admet-376	788	11	the	the	DET
admet-376	788	12	terms	term	NOUN
admet-376	788	13	and	and	CCONJ
admet-376	788	14	conditions	condition	NOUN
admet-376	788	15	of	of	ADP
admet-376	788	16	the	the	DET
admet-376	788	17	creative	creative	ADJ
admet-376	788	18	commons	common	NOUN
admet-376	788	19	attribution	attribution	NOUN
admet-376	788	20	license	license	NOUN
admet-376	788	21	(	(	PUNCT
admet-376	788	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-376	788	23	)	)	PUNCT
admet-376	788	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN