id	sid	tid	token	lemma	pos
admet-387	1	1	manuscript	manuscript	PROPN
admet-387	1	2	doi	doi	PROPN
admet-387	1	3	:	:	PUNCT
admet-387	1	4	10.5599	10.5599	NUM
admet-387	1	5	/	/	SYM
admet-387	1	6	admet.5.1.387	admet.5.1.387	PROPN
admet-387	1	7	59	59	NUM
admet-387	1	8	admet	admet	X
admet-387	1	9	&	&	CCONJ
admet-387	1	10	dmpk	dmpk	PROPN
admet-387	1	11	5(2	5(2	NUM
admet-387	1	12	)	)	PUNCT
admet-387	1	13	(	(	PUNCT
admet-387	1	14	2017	2017	NUM
admet-387	1	15	)	)	PUNCT
admet-387	1	16	59	59	NUM
admet-387	1	17	-	-	SYM
admet-387	1	18	74	74	NUM
admet-387	1	19	;	;	PUNCT
admet-387	1	20	doi	doi	NOUN
admet-387	1	21	:	:	PUNCT
admet-387	1	22	10.5599	10.5599	NUM
admet-387	1	23	/	/	SYM
admet-387	1	24	admet.5.2.387	admet.5.2.387	NOUN
admet-387	1	25	open	open	ADJ
admet-387	1	26	access	access	NOUN
admet-387	1	27	:	:	PUNCT
admet-387	1	28	issn	issn	PROPN
admet-387	1	29	:	:	PUNCT
admet-387	1	30	1848	1848	NUM
admet-387	1	31	-	-	SYM
admet-387	1	32	7718	7718	NUM
admet-387	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-387	1	34	review	review	NOUN
admet-387	1	35	uric	uric	ADJ
admet-387	1	36	acid	acid	NOUN
admet-387	1	37	transporter	transporter	NOUN
admet-387	1	38	inhibitors	inhibitor	NOUN
admet-387	1	39	for	for	ADP
admet-387	1	40	gout	gout	PROPN
admet-387	1	41	philip	philip	PROPN
admet-387	1	42	k.	k.	PROPN
admet-387	1	43	tan	tan	PROPN
admet-387	1	44	and	and	CCONJ
admet-387	1	45	jeffrey	jeffrey	PROPN
admet-387	1	46	n.	n.	PROPN
admet-387	1	47	miner	miner	PROPN
admet-387	1	48	*	*	PROPN
admet-387	1	49	pharmadiscovery	pharmadiscovery	NOUN
admet-387	1	50	consulting	consulting	NOUN
admet-387	1	51	llc	llc	PROPN
admet-387	1	52	,	,	PUNCT
admet-387	1	53	san	san	PROPN
admet-387	1	54	diego	diego	PROPN
admet-387	1	55	,	,	PUNCT
admet-387	1	56	ca	ca	PROPN
admet-387	1	57	92122	92122	NUM
admet-387	1	58	*	*	PUNCT
admet-387	1	59	corresponding	correspond	VERB
admet-387	1	60	author	author	NOUN
admet-387	1	61	:	:	PUNCT
admet-387	1	62	e	e	NOUN
admet-387	1	63	-	-	NOUN
admet-387	1	64	mail	mail	NOUN
admet-387	1	65	:	:	PUNCT
admet-387	1	66	pharmadiscoveryconsulting@gmail.com	pharmadiscoveryconsulting@gmail.com	X
admet-387	1	67	;	;	PUNCT
admet-387	1	68	received	receive	VERB
admet-387	1	69	:	:	PUNCT
admet-387	1	70	april	april	PROPN
admet-387	1	71	20	20	NUM
admet-387	1	72	,	,	PUNCT
admet-387	1	73	2017	2017	NUM
admet-387	1	74	;	;	PUNCT
admet-387	1	75	revised	revise	VERB
admet-387	1	76	:	:	PUNCT
admet-387	1	77	may	may	AUX
admet-387	1	78	21	21	NUM
admet-387	1	79	,	,	PUNCT
admet-387	1	80	2017	2017	NUM
admet-387	1	81	;	;	PUNCT
admet-387	1	82	published	publish	VERB
admet-387	1	83	:	:	PUNCT
admet-387	1	84	june	june	PROPN
admet-387	1	85	22	22	NUM
admet-387	1	86	,	,	PUNCT
admet-387	1	87	2017	2017	NUM
admet-387	1	88	abstract	abstract	ADJ
admet-387	1	89	gout	gout	NOUN
admet-387	1	90	is	be	AUX
admet-387	1	91	a	a	DET
admet-387	1	92	common	common	ADJ
admet-387	1	93	inflammatory	inflammatory	ADJ
admet-387	1	94	arthritis	arthritis	NOUN
admet-387	1	95	that	that	PRON
admet-387	1	96	is	be	AUX
admet-387	1	97	caused	cause	VERB
admet-387	1	98	by	by	ADP
admet-387	1	99	chronically	chronically	ADV
admet-387	1	100	-	-	PUNCT
admet-387	1	101	elevated	elevate	VERB
admet-387	1	102	serum	serum	NOUN
admet-387	1	103	uric	uric	ADJ
admet-387	1	104	acid	acid	PROPN
admet-387	1	105	(	(	PUNCT
admet-387	1	106	sua	sua	NOUN
admet-387	1	107	)	)	PUNCT
admet-387	1	108	levels	level	NOUN
admet-387	1	109	(	(	PUNCT
admet-387	1	110	hyperuricemia	hyperuricemia	NOUN
admet-387	1	111	)	)	PUNCT
admet-387	1	112	.	.	PUNCT
admet-387	2	1	in	in	ADP
admet-387	2	2	humans	human	NOUN
admet-387	2	3	,	,	PUNCT
admet-387	2	4	sua	sua	PROPN
admet-387	2	5	levels	level	NOUN
admet-387	2	6	are	be	AUX
admet-387	2	7	predominantly	predominantly	ADV
admet-387	2	8	controlled	control	VERB
admet-387	2	9	by	by	ADP
admet-387	2	10	a	a	DET
admet-387	2	11	variety	variety	NOUN
admet-387	2	12	of	of	ADP
admet-387	2	13	transporters	transporter	NOUN
admet-387	2	14	that	that	PRON
admet-387	2	15	mediate	mediate	VERB
admet-387	2	16	the	the	DET
admet-387	2	17	elimination	elimination	NOUN
admet-387	2	18	of	of	ADP
admet-387	2	19	uric	uric	ADJ
admet-387	2	20	acid	acid	NOUN
admet-387	2	21	through	through	ADP
admet-387	2	22	the	the	DET
admet-387	2	23	kidneys	kidney	NOUN
admet-387	2	24	and	and	CCONJ
admet-387	2	25	intestines	intestine	NOUN
admet-387	2	26	,	,	PUNCT
admet-387	2	27	a	a	DET
admet-387	2	28	process	process	NOUN
admet-387	2	29	that	that	PRON
admet-387	2	30	is	be	AUX
admet-387	2	31	altered	alter	VERB
admet-387	2	32	in	in	ADP
admet-387	2	33	most	most	ADJ
admet-387	2	34	gout	gout	NOUN
admet-387	2	35	patients	patient	NOUN
admet-387	2	36	.	.	PUNCT
admet-387	3	1	in	in	ADP
admet-387	3	2	this	this	DET
admet-387	3	3	review	review	NOUN
admet-387	3	4	,	,	PUNCT
admet-387	3	5	we	we	PRON
admet-387	3	6	highlight	highlight	VERB
admet-387	3	7	our	our	PRON
admet-387	3	8	current	current	ADJ
admet-387	3	9	understanding	understanding	NOUN
admet-387	3	10	of	of	ADP
admet-387	3	11	uric	uric	ADJ
admet-387	3	12	acid	acid	NOUN
admet-387	3	13	handling	handling	NOUN
admet-387	3	14	in	in	ADP
admet-387	3	15	healthy	healthy	ADJ
admet-387	3	16	individuals	individual	NOUN
admet-387	3	17	and	and	CCONJ
admet-387	3	18	gout	gout	NOUN
admet-387	3	19	patients	patient	NOUN
admet-387	3	20	,	,	PUNCT
admet-387	3	21	therapies	therapy	NOUN
admet-387	3	22	for	for	ADP
admet-387	3	23	gout	gout	NOUN
admet-387	3	24	that	that	PRON
admet-387	3	25	target	target	VERB
admet-387	3	26	uric	uric	ADJ
admet-387	3	27	acid	acid	NOUN
admet-387	3	28	transporters	transporter	NOUN
admet-387	3	29	,	,	PUNCT
admet-387	3	30	and	and	CCONJ
admet-387	3	31	the	the	DET
admet-387	3	32	mechanism	mechanism	NOUN
admet-387	3	33	of	of	ADP
admet-387	3	34	other	other	ADJ
admet-387	3	35	therapies	therapy	NOUN
admet-387	3	36	that	that	PRON
admet-387	3	37	alter	alter	PROPN
admet-387	3	38	sua	sua	PROPN
admet-387	3	39	levels	level	NOUN
admet-387	3	40	through	through	ADP
admet-387	3	41	interactions	interaction	NOUN
admet-387	3	42	with	with	ADP
admet-387	3	43	uric	uric	ADJ
admet-387	3	44	acid	acid	NOUN
admet-387	3	45	transporters	transporter	NOUN
admet-387	3	46	.	.	PUNCT
admet-387	4	1	keywords	keyword	VERB
admet-387	4	2	gout	gout	NOUN
admet-387	4	3	;	;	PUNCT
admet-387	4	4	hyperuricemia	hyperuricemia	ADV
admet-387	4	5	;	;	PUNCT
admet-387	4	6	uricase	uricase	ADJ
admet-387	4	7	;	;	PUNCT
admet-387	4	8	urat1	urat1	PROPN
admet-387	4	9	;	;	PUNCT
admet-387	4	10	coevolution	coevolution	NOUN
admet-387	4	11	;	;	PUNCT
admet-387	4	12	urate	urate	NOUN
admet-387	4	13	transporters	transporter	NOUN
admet-387	4	14	for	for	ADP
admet-387	4	15	urate	urate	NOUN
admet-387	4	16	homeostasis	homeostasis	NOUN
admet-387	4	17	overview	overview	NOUN
admet-387	4	18	gout	gout	NOUN
admet-387	4	19	and	and	CCONJ
admet-387	4	20	hyperuricemia	hyperuricemia	NOUN
admet-387	4	21	gout	gout	NOUN
admet-387	4	22	is	be	AUX
admet-387	4	23	a	a	DET
admet-387	4	24	debilitating	debilitate	VERB
admet-387	4	25	inflammatory	inflammatory	ADJ
admet-387	4	26	arthritis	arthritis	NOUN
admet-387	4	27	of	of	ADP
admet-387	4	28	increasing	increase	VERB
admet-387	4	29	prevalence	prevalence	NOUN
admet-387	4	30	that	that	PRON
admet-387	4	31	is	be	AUX
admet-387	4	32	caused	cause	VERB
admet-387	4	33	by	by	ADP
admet-387	4	34	chronically	chronically	ADV
admet-387	4	35	elevated	elevate	VERB
admet-387	4	36	levels	level	NOUN
admet-387	4	37	of	of	ADP
admet-387	4	38	serum	serum	PROPN
admet-387	4	39	uric	uric	ADJ
admet-387	4	40	acid	acid	PROPN
admet-387	4	41	(	(	PUNCT
admet-387	4	42	sua	sua	NOUN
admet-387	4	43	)	)	PUNCT
admet-387	4	44	,	,	PUNCT
admet-387	4	45	or	or	CCONJ
admet-387	4	46	hyperuricemia	hyperuricemia	NOUN
admet-387	4	47	,	,	PUNCT
admet-387	4	48	defined	define	VERB
admet-387	4	49	as	as	ADP
admet-387	4	50	concentrations	concentration	NOUN
admet-387	4	51	exceeding	exceed	VERB
admet-387	4	52	6.8	6.8	NUM
admet-387	4	53	mg	mg	PROPN
admet-387	4	54	/	/	SYM
admet-387	4	55	dl	dl	PROPN
admet-387	5	1	(	(	PUNCT
admet-387	5	2	408	408	NUM
admet-387	5	3	μm	μm	NUM
admet-387	5	4	)	)	PUNCT
admet-387	5	5	.	.	PUNCT
admet-387	6	1	in	in	ADP
admet-387	6	2	healthy	healthy	ADJ
admet-387	6	3	nongouty	nongouty	PROPN
admet-387	6	4	individuals	individual	NOUN
admet-387	6	5	,	,	PUNCT
admet-387	6	6	serum	serum	NOUN
admet-387	6	7	urate	urate	NOUN
admet-387	6	8	levels	level	NOUN
admet-387	6	9	are	be	AUX
admet-387	6	10	normally	normally	ADV
admet-387	6	11	in	in	ADP
admet-387	6	12	the	the	DET
admet-387	6	13	range	range	NOUN
admet-387	6	14	of	of	ADP
admet-387	6	15	3.5	3.5	NUM
admet-387	6	16	-	-	SYM
admet-387	6	17	7	7	NUM
admet-387	6	18	mg	mg	PROPN
admet-387	6	19	/	/	SYM
admet-387	6	20	dl	dl	PROPN
admet-387	6	21	(	(	PUNCT
admet-387	6	22	210	210	NUM
admet-387	6	23	–	–	SYM
admet-387	6	24	420	420	NUM
admet-387	6	25	μm	μm	NOUN
admet-387	6	26	)	)	PUNCT
admet-387	7	1	[	[	X
admet-387	7	2	1	1	NUM
admet-387	7	3	]	]	PUNCT
admet-387	7	4	.	.	PUNCT
admet-387	8	1	prolonged	prolong	VERB
admet-387	8	2	hyperuricemia	hyperuricemia	NOUN
admet-387	8	3	can	can	AUX
admet-387	8	4	initiate	initiate	VERB
admet-387	8	5	the	the	DET
admet-387	8	6	precipitation	precipitation	NOUN
admet-387	8	7	of	of	ADP
admet-387	8	8	the	the	DET
admet-387	8	9	uric	uric	ADJ
admet-387	8	10	acid	acid	NOUN
admet-387	8	11	in	in	ADP
admet-387	8	12	joints	joint	NOUN
admet-387	8	13	and	and	CCONJ
admet-387	8	14	other	other	ADJ
admet-387	8	15	tissues	tissue	NOUN
admet-387	8	16	,	,	PUNCT
admet-387	8	17	and	and	CCONJ
admet-387	8	18	these	these	DET
admet-387	8	19	deposits	deposit	NOUN
admet-387	8	20	can	can	AUX
admet-387	8	21	trigger	trigger	VERB
admet-387	8	22	an	an	DET
admet-387	8	23	acute	acute	ADJ
admet-387	8	24	and	and	CCONJ
admet-387	8	25	painful	painful	ADJ
admet-387	8	26	immune	immune	ADJ
admet-387	8	27	response	response	NOUN
admet-387	8	28	known	know	VERB
admet-387	8	29	as	as	ADP
admet-387	8	30	a	a	DET
admet-387	8	31	gout	gout	NOUN
admet-387	8	32	flare	flare	NOUN
admet-387	8	33	.	.	PUNCT
admet-387	9	1	hyperuricemia	hyperuricemia	NOUN
admet-387	9	2	is	be	AUX
admet-387	9	3	also	also	ADV
admet-387	9	4	strongly	strongly	ADV
admet-387	9	5	and	and	CCONJ
admet-387	9	6	independently	independently	ADV
admet-387	9	7	associated	associate	VERB
admet-387	9	8	with	with	ADP
admet-387	9	9	a	a	DET
admet-387	9	10	number	number	NOUN
admet-387	9	11	of	of	ADP
admet-387	9	12	other	other	ADJ
admet-387	9	13	important	important	ADJ
admet-387	9	14	disorders	disorder	NOUN
admet-387	9	15	including	include	VERB
admet-387	9	16	hypertension	hypertension	NOUN
admet-387	9	17	,	,	PUNCT
admet-387	9	18	cardiovascular	cardiovascular	ADJ
admet-387	9	19	disease	disease	NOUN
admet-387	9	20	and	and	CCONJ
admet-387	9	21	metabolic	metabolic	NOUN
admet-387	9	22	syndrome	syndrome	NOUN
admet-387	10	1	[	[	X
admet-387	10	2	2	2	NUM
admet-387	10	3	]	]	PUNCT
admet-387	10	4	.	.	PUNCT
admet-387	11	1	a	a	DET
admet-387	11	2	number	number	NOUN
admet-387	11	3	of	of	ADP
admet-387	11	4	therapies	therapy	NOUN
admet-387	11	5	for	for	ADP
admet-387	11	6	gout	gout	NOUN
admet-387	11	7	that	that	PRON
admet-387	11	8	lower	low	ADJ
admet-387	11	9	sua	sua	PROPN
admet-387	11	10	levels	level	NOUN
admet-387	11	11	target	target	VERB
admet-387	11	12	transporters	transporter	NOUN
admet-387	11	13	for	for	ADP
admet-387	11	14	uric	uric	ADJ
admet-387	11	15	acid	acid	NOUN
admet-387	11	16	,	,	PUNCT
admet-387	11	17	some	some	PRON
admet-387	11	18	which	which	PRON
admet-387	11	19	are	be	AUX
admet-387	11	20	also	also	ADV
admet-387	11	21	important	important	ADJ
admet-387	11	22	drug	drug	NOUN
admet-387	11	23	transporters	transporter	NOUN
admet-387	11	24	.	.	PUNCT
admet-387	12	1	uric	uric	ADJ
admet-387	12	2	acid	acid	NOUN
admet-387	12	3	homeostasis	homeostasis	NOUN
admet-387	12	4	in	in	ADP
admet-387	12	5	humans	human	NOUN
admet-387	12	6	in	in	ADP
admet-387	12	7	health	health	NOUN
admet-387	12	8	and	and	CCONJ
admet-387	12	9	disease	disease	NOUN
admet-387	12	10	uric	uric	ADJ
admet-387	12	11	acid	acid	PROPN
admet-387	12	12	is	be	AUX
admet-387	12	13	produced	produce	VERB
admet-387	12	14	mainly	mainly	ADV
admet-387	12	15	in	in	ADP
admet-387	12	16	the	the	DET
admet-387	12	17	liver	liver	NOUN
admet-387	12	18	and	and	CCONJ
admet-387	12	19	gastrointestinal	gastrointestinal	ADJ
admet-387	12	20	tract	tract	NOUN
admet-387	12	21	by	by	ADP
admet-387	12	22	the	the	DET
admet-387	12	23	degradation	degradation	NOUN
admet-387	12	24	of	of	ADP
admet-387	12	25	endogenous	endogenous	ADJ
admet-387	12	26	and	and	CCONJ
admet-387	12	27	dietary	dietary	ADJ
admet-387	12	28	purines	purine	NOUN
admet-387	12	29	.	.	PUNCT
admet-387	13	1	sources	source	NOUN
admet-387	13	2	of	of	ADP
admet-387	13	3	endogenous	endogenous	ADJ
admet-387	13	4	purines	purine	NOUN
admet-387	13	5	include	include	VERB
admet-387	13	6	nucleotides	nucleotide	NOUN
admet-387	13	7	such	such	ADJ
admet-387	13	8	as	as	ADP
admet-387	13	9	atp	atp	PROPN
admet-387	13	10	,	,	PUNCT
admet-387	13	11	and	and	CCONJ
admet-387	13	12	dna	dna	PROPN
admet-387	13	13	and	and	CCONJ
admet-387	13	14	rna	rna	NOUN
admet-387	13	15	that	that	PRON
admet-387	13	16	are	be	AUX
admet-387	13	17	recovered	recover	VERB
admet-387	13	18	from	from	ADP
admet-387	13	19	dying	die	VERB
admet-387	13	20	cells	cell	NOUN
admet-387	13	21	.	.	PUNCT
admet-387	14	1	these	these	DET
admet-387	14	2	purines	purine	NOUN
admet-387	14	3	are	be	AUX
admet-387	14	4	degraded	degrade	VERB
admet-387	14	5	into	into	ADP
admet-387	14	6	uric	uric	ADJ
admet-387	14	7	acid	acid	NOUN
admet-387	14	8	by	by	ADP
admet-387	14	9	xanthine	xanthine	NOUN
admet-387	14	10	oxidase	oxidase	NOUN
admet-387	14	11	in	in	ADP
admet-387	14	12	the	the	DET
admet-387	14	13	liver	liver	NOUN
admet-387	14	14	.	.	PUNCT
admet-387	15	1	dietary	dietary	ADJ
admet-387	15	2	purines	purine	NOUN
admet-387	15	3	are	be	AUX
admet-387	15	4	absorbed	absorb	VERB
admet-387	15	5	in	in	ADP
admet-387	15	6	the	the	DET
admet-387	15	7	gut	gut	NOUN
admet-387	15	8	by	by	ADP
admet-387	15	9	the	the	DET
admet-387	15	10	cnt2	cnt2	NOUN
admet-387	15	11	transporter	transporter	NOUN
admet-387	15	12	and	and	CCONJ
admet-387	15	13	are	be	AUX
admet-387	15	14	quantitatively	quantitatively	ADV
admet-387	15	15	metabolized	metabolize	VERB
admet-387	15	16	to	to	ADP
admet-387	15	17	uric	uric	ADJ
admet-387	15	18	acid	acid	NOUN
admet-387	15	19	by	by	ADP
admet-387	15	20	endogenous	endogenous	ADJ
admet-387	15	21	xanthine	xanthine	NOUN
admet-387	15	22	oxidase	oxidase	NOUN
admet-387	15	23	within	within	ADP
admet-387	15	24	intestinal	intestinal	ADJ
admet-387	15	25	enterocytes	enterocyte	NOUN
admet-387	15	26	(	(	PUNCT
admet-387	15	27	see	see	VERB
admet-387	15	28	figure	figure	NOUN
admet-387	15	29	1b	1b	NUM
admet-387	15	30	)	)	PUNCT
admet-387	15	31	.	.	PUNCT
admet-387	16	1	in	in	ADP
admet-387	16	2	non	non	ADJ
admet-387	16	3	-	-	ADJ
admet-387	16	4	primate	primate	ADJ
admet-387	16	5	mammals	mammal	NOUN
admet-387	16	6	,	,	PUNCT
admet-387	16	7	uric	uric	ADJ
admet-387	16	8	acid	acid	NOUN
admet-387	16	9	is	be	AUX
admet-387	16	10	converted	convert	VERB
admet-387	16	11	to	to	ADP
admet-387	16	12	more	more	ADV
admet-387	16	13	highly	highly	ADV
admet-387	16	14	soluble	soluble	ADJ
admet-387	16	15	allantoin	allantoin	NOUN
admet-387	16	16	by	by	ADP
admet-387	16	17	urate	urate	NOUN
admet-387	16	18	oxidase	oxidase	NOUN
admet-387	16	19	(	(	PUNCT
admet-387	16	20	uricase	uricase	NOUN
admet-387	16	21	)	)	PUNCT
admet-387	16	22	.	.	PUNCT
admet-387	17	1	in	in	ADP
admet-387	17	2	primates	primate	NOUN
admet-387	17	3	including	include	VERB
admet-387	17	4	humans	human	NOUN
admet-387	17	5	,	,	PUNCT
admet-387	17	6	however	however	ADV
admet-387	17	7	,	,	PUNCT
admet-387	17	8	uric	uric	ADJ
admet-387	17	9	acid	acid	NOUN
admet-387	17	10	is	be	AUX
admet-387	17	11	the	the	DET
admet-387	17	12	end	end	NOUN
admet-387	17	13	product	product	NOUN
admet-387	17	14	of	of	ADP
admet-387	17	15	purine	purine	NOUN
admet-387	17	16	catabolism	catabolism	NOUN
admet-387	17	17	due	due	ADP
admet-387	17	18	to	to	ADP
admet-387	17	19	the	the	DET
admet-387	17	20	progressive	progressive	ADJ
admet-387	17	21	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-387	17	22	mailto:pharmadiscoveryconsulting@gmail.com	mailto:pharmadiscoveryconsulting@gmail.com	PROPN
admet-387	17	23	tan	tan	PROPN
admet-387	17	24	and	and	CCONJ
admet-387	17	25	miner	miner	PROPN
admet-387	17	26	admet	admet	PROPN
admet-387	17	27	&	&	CCONJ
admet-387	17	28	dmpk	dmpk	PROPN
admet-387	17	29	5(2	5(2	NUM
admet-387	17	30	)	)	PUNCT
admet-387	17	31	(	(	PUNCT
admet-387	17	32	2017	2017	NUM
admet-387	17	33	)	)	PUNCT
admet-387	17	34	59	59	NUM
admet-387	17	35	-	-	SYM
admet-387	17	36	74	74	NUM
admet-387	17	37	60	60	NUM
admet-387	17	38	inactivation	inactivation	NOUN
admet-387	17	39	of	of	ADP
admet-387	17	40	uricase	uricase	NOUN
admet-387	17	41	in	in	ADP
admet-387	17	42	primate	primate	ADJ
admet-387	17	43	evolution	evolution	NOUN
admet-387	17	44	[	[	X
admet-387	17	45	3	3	NUM
admet-387	17	46	]	]	PUNCT
admet-387	17	47	hence	hence	ADV
admet-387	17	48	primates	primate	NOUN
admet-387	17	49	have	have	VERB
admet-387	17	50	sua	sua	NOUN
admet-387	17	51	levels	level	NOUN
admet-387	17	52	that	that	PRON
admet-387	17	53	are	be	AUX
admet-387	17	54	3	3	NUM
admet-387	17	55	-	-	SYM
admet-387	17	56	10	10	NUM
admet-387	17	57	times	time	NOUN
admet-387	17	58	higher	high	ADJ
admet-387	17	59	than	than	ADP
admet-387	17	60	other	other	ADJ
admet-387	17	61	mammals	mammal	NOUN
admet-387	17	62	.	.	PUNCT
admet-387	18	1	the	the	DET
admet-387	18	2	xanthine	xanthine	NOUN
admet-387	18	3	oxidase	oxidase	NOUN
admet-387	18	4	inhibitor	inhibitor	NOUN
admet-387	18	5	(	(	PUNCT
admet-387	18	6	xoi	xoi	NOUN
admet-387	18	7	)	)	PUNCT
admet-387	18	8	class	class	NOUN
admet-387	18	9	of	of	ADP
admet-387	18	10	urate	urate	NOUN
admet-387	18	11	-	-	PUNCT
admet-387	18	12	lowering	lower	VERB
admet-387	18	13	therapies	therapy	NOUN
admet-387	18	14	for	for	ADP
admet-387	18	15	gout	gout	NOUN
admet-387	18	16	(	(	PUNCT
admet-387	18	17	allopurinol	allopurinol	NOUN
admet-387	18	18	and	and	CCONJ
admet-387	18	19	febuxostat	febuxostat	NOUN
admet-387	18	20	)	)	PUNCT
admet-387	18	21	block	block	VERB
admet-387	18	22	the	the	DET
admet-387	18	23	enzyme	enzyme	NOUN
admet-387	18	24	xanthine	xanthine	NOUN
admet-387	18	25	oxidase	oxidase	NOUN
admet-387	18	26	that	that	PRON
admet-387	18	27	produces	produce	VERB
admet-387	18	28	uric	uric	ADJ
admet-387	18	29	acid	acid	NOUN
admet-387	18	30	in	in	ADP
admet-387	18	31	the	the	DET
admet-387	18	32	last	last	ADJ
admet-387	18	33	step	step	NOUN
admet-387	18	34	of	of	ADP
admet-387	18	35	purine	purine	NOUN
admet-387	18	36	catabolism	catabolism	NOUN
admet-387	18	37	in	in	ADP
admet-387	18	38	primates	primate	NOUN
admet-387	18	39	[	[	X
admet-387	18	40	4	4	NUM
admet-387	18	41	]	]	PUNCT
admet-387	18	42	.	.	PUNCT
admet-387	19	1	uric	uric	ADJ
admet-387	19	2	acid	acid	NOUN
admet-387	19	3	production	production	NOUN
admet-387	19	4	is	be	AUX
admet-387	19	5	balanced	balance	VERB
admet-387	19	6	by	by	ADP
admet-387	19	7	elimination	elimination	NOUN
admet-387	19	8	,	,	PUNCT
admet-387	19	9	which	which	PRON
admet-387	19	10	in	in	ADP
admet-387	19	11	humans	human	NOUN
admet-387	19	12	occurs	occur	VERB
admet-387	19	13	mainly	mainly	ADV
admet-387	19	14	through	through	ADP
admet-387	19	15	the	the	DET
admet-387	19	16	kidneys	kidney	NOUN
admet-387	19	17	(	(	PUNCT
admet-387	19	18	70	70	NUM
admet-387	19	19	%	%	NOUN
admet-387	19	20	of	of	ADP
admet-387	19	21	the	the	DET
admet-387	19	22	total	total	NOUN
admet-387	19	23	eliminated	eliminate	VERB
admet-387	19	24	uric	uric	ADJ
admet-387	19	25	acid	acid	NOUN
admet-387	19	26	)	)	PUNCT
admet-387	19	27	but	but	CCONJ
admet-387	19	28	also	also	ADV
admet-387	19	29	through	through	ADP
admet-387	19	30	the	the	DET
admet-387	19	31	intestines	intestine	NOUN
admet-387	19	32	(	(	PUNCT
admet-387	19	33	30	30	NUM
admet-387	19	34	%	%	NOUN
admet-387	19	35	of	of	ADP
admet-387	19	36	the	the	DET
admet-387	19	37	total	total	NOUN
admet-387	19	38	eliminated	eliminate	VERB
admet-387	19	39	uric	uric	ADJ
admet-387	19	40	acid	acid	NOUN
admet-387	19	41	)	)	PUNCT
admet-387	19	42	.	.	PUNCT
admet-387	20	1	with	with	ADP
admet-387	20	2	a	a	DET
admet-387	20	3	pka	pka	NOUN
admet-387	20	4	of	of	ADP
admet-387	20	5	5.35	5.35	NUM
admet-387	20	6	[	[	X
admet-387	20	7	5	5	NUM
admet-387	20	8	]	]	PUNCT
admet-387	20	9	,	,	PUNCT
admet-387	20	10	uric	uric	ADJ
admet-387	20	11	acid	acid	PROPN
admet-387	20	12	is	be	AUX
admet-387	20	13	the	the	DET
admet-387	20	14	negatively	negatively	ADV
admet-387	20	15	charged	charge	VERB
admet-387	20	16	organic	organic	ADJ
admet-387	20	17	anion	anion	NOUN
admet-387	20	18	urate	urate	NOUN
admet-387	20	19	at	at	ADP
admet-387	20	20	physiological	physiological	ADJ
admet-387	20	21	ph	ph	NOUN
admet-387	20	22	and	and	CCONJ
admet-387	20	23	so	so	ADV
admet-387	20	24	requires	require	VERB
admet-387	20	25	transporters	transporter	NOUN
admet-387	20	26	for	for	ADP
admet-387	20	27	passage	passage	NOUN
admet-387	20	28	through	through	ADP
admet-387	20	29	cell	cell	NOUN
admet-387	20	30	membranes	membrane	NOUN
admet-387	20	31	.	.	PUNCT
admet-387	21	1	genetic	genetic	ADJ
admet-387	21	2	studies	study	NOUN
admet-387	21	3	show	show	VERB
admet-387	21	4	that	that	SCONJ
admet-387	21	5	a	a	DET
admet-387	21	6	large	large	ADJ
admet-387	21	7	number	number	NOUN
admet-387	21	8	of	of	ADP
admet-387	21	9	urate	urate	NOUN
admet-387	21	10	transporters	transporter	NOUN
admet-387	21	11	(	(	PUNCT
admet-387	21	12	glut9	glut9	NOUN
admet-387	21	13	,	,	PUNCT
admet-387	21	14	abcg2	abcg2	NOUN
admet-387	21	15	,	,	PUNCT
admet-387	21	16	npt1/3/4	npt1/3/4	PROPN
admet-387	21	17	,	,	PUNCT
admet-387	21	18	urat1	urat1	PROPN
admet-387	21	19	,	,	PUNCT
admet-387	21	20	oat4	oat4	NOUN
admet-387	21	21	,	,	PUNCT
admet-387	21	22	mrp4	mrp4	PROPN
admet-387	21	23	)	)	PUNCT
admet-387	21	24	are	be	AUX
admet-387	21	25	important	important	ADJ
admet-387	21	26	for	for	ADP
admet-387	21	27	urate	urate	NOUN
admet-387	21	28	homeostasis	homeostasis	NOUN
admet-387	21	29	in	in	ADP
admet-387	21	30	humans	human	NOUN
admet-387	21	31	[	[	X
admet-387	21	32	6	6	NUM
admet-387	21	33	-	-	SYM
admet-387	21	34	8	8	NUM
admet-387	21	35	]	]	PUNCT
admet-387	21	36	which	which	PRON
admet-387	21	37	are	be	AUX
admet-387	21	38	expressed	express	VERB
admet-387	21	39	in	in	ADP
admet-387	21	40	the	the	DET
admet-387	21	41	organs	organ	NOUN
admet-387	21	42	that	that	PRON
admet-387	21	43	eliminate	eliminate	VERB
admet-387	21	44	uric	uric	ADJ
admet-387	21	45	acid	acid	NOUN
admet-387	21	46	.	.	PUNCT
admet-387	22	1	in	in	ADP
admet-387	22	2	the	the	DET
admet-387	22	3	kidney	kidney	NOUN
admet-387	22	4	nephrons	nephron	NOUN
admet-387	22	5	,	,	PUNCT
admet-387	22	6	uric	uric	ADJ
admet-387	22	7	acid	acid	NOUN
admet-387	22	8	handling	handling	NOUN
admet-387	22	9	occurs	occur	VERB
admet-387	22	10	in	in	ADP
admet-387	22	11	a	a	DET
admet-387	22	12	complex	complex	ADJ
admet-387	22	13	process	process	NOUN
admet-387	22	14	involving	involve	VERB
admet-387	22	15	complete	complete	ADJ
admet-387	22	16	and	and	CCONJ
admet-387	22	17	free	free	ADJ
admet-387	22	18	filtration	filtration	NOUN
admet-387	22	19	into	into	ADP
admet-387	22	20	the	the	DET
admet-387	22	21	glomerulus	glomerulus	NOUN
admet-387	22	22	,	,	PUNCT
admet-387	22	23	followed	follow	VERB
admet-387	22	24	by	by	ADP
admet-387	22	25	near	near	ADP
admet-387	22	26	complete	complete	ADJ
admet-387	22	27	90	90	NUM
admet-387	22	28	-	-	SYM
admet-387	22	29	95	95	NUM
admet-387	22	30	%	%	NOUN
admet-387	22	31	reabsorption	reabsorption	NOUN
admet-387	22	32	in	in	ADP
admet-387	22	33	the	the	DET
admet-387	22	34	proximal	proximal	ADJ
admet-387	22	35	tubules	tubule	NOUN
admet-387	22	36	back	back	ADV
admet-387	22	37	to	to	ADP
admet-387	22	38	the	the	DET
admet-387	22	39	bloodstream	bloodstream	NOUN
admet-387	22	40	(	(	PUNCT
admet-387	22	41	figure	figure	NOUN
admet-387	22	42	1a	1a	NOUN
admet-387	22	43	)	)	PUNCT
admet-387	22	44	.	.	PUNCT
admet-387	23	1	uric	uric	ADJ
admet-387	23	2	acid	acid	NOUN
admet-387	23	3	that	that	PRON
admet-387	23	4	is	be	AUX
admet-387	23	5	not	not	PART
admet-387	23	6	reabsorbed	reabsorb	VERB
admet-387	23	7	in	in	ADP
admet-387	23	8	the	the	DET
admet-387	23	9	proximal	proximal	ADJ
admet-387	23	10	tubule	tubule	NOUN
admet-387	23	11	(	(	PUNCT
admet-387	23	12	5	5	NUM
admet-387	23	13	-	-	SYM
admet-387	23	14	10	10	NUM
admet-387	23	15	%	%	NOUN
admet-387	23	16	of	of	ADP
admet-387	23	17	the	the	DET
admet-387	23	18	glomerular	glomerular	ADJ
admet-387	23	19	-	-	PUNCT
admet-387	23	20	filtered	filter	VERB
admet-387	23	21	uric	uric	ADJ
admet-387	23	22	acid	acid	NOUN
admet-387	23	23	)	)	PUNCT
admet-387	23	24	passes	pass	VERB
admet-387	23	25	through	through	ADP
admet-387	23	26	the	the	DET
admet-387	23	27	nephron	nephron	NOUN
admet-387	23	28	and	and	CCONJ
admet-387	23	29	is	be	AUX
admet-387	23	30	excreted	excrete	VERB
admet-387	23	31	into	into	ADP
admet-387	23	32	the	the	DET
admet-387	23	33	urine	urine	NOUN
admet-387	23	34	,	,	PUNCT
admet-387	23	35	and	and	CCONJ
admet-387	23	36	there	there	PRON
admet-387	23	37	is	be	VERB
admet-387	23	38	little	little	ADJ
admet-387	23	39	evidence	evidence	NOUN
admet-387	23	40	that	that	SCONJ
admet-387	23	41	uric	uric	ADJ
admet-387	23	42	acid	acid	NOUN
admet-387	23	43	can	can	AUX
admet-387	23	44	pass	pass	VERB
admet-387	23	45	through	through	ADP
admet-387	23	46	the	the	DET
admet-387	23	47	walls	wall	NOUN
admet-387	23	48	of	of	ADP
admet-387	23	49	the	the	DET
admet-387	23	50	more	more	ADV
admet-387	23	51	distal	distal	ADJ
admet-387	23	52	segments	segment	NOUN
admet-387	23	53	of	of	ADP
admet-387	23	54	the	the	DET
admet-387	23	55	nephron	nephron	NOUN
admet-387	23	56	.	.	PUNCT
admet-387	24	1	the	the	DET
admet-387	24	2	transporters	transporter	NOUN
admet-387	24	3	involved	involve	VERB
admet-387	24	4	in	in	ADP
admet-387	24	5	the	the	DET
admet-387	24	6	proximal	proximal	ADJ
admet-387	24	7	tubule	tubule	NOUN
admet-387	24	8	handling	handling	NOUN
admet-387	24	9	of	of	ADP
admet-387	24	10	uric	uric	ADJ
admet-387	24	11	acid	acid	NOUN
admet-387	24	12	are	be	AUX
admet-387	24	13	shown	show	VERB
admet-387	24	14	in	in	ADP
admet-387	24	15	figure	figure	NOUN
admet-387	24	16	1a	1a	NOUN
admet-387	24	17	and	and	CCONJ
admet-387	24	18	are	be	AUX
admet-387	24	19	described	describe	VERB
admet-387	24	20	in	in	ADP
admet-387	24	21	detail	detail	NOUN
admet-387	24	22	below	below	ADV
admet-387	24	23	.	.	PUNCT
admet-387	25	1	a	a	DET
admet-387	25	2	)	)	PUNCT
admet-387	25	3	b	b	NOUN
admet-387	25	4	)	)	PUNCT
admet-387	25	5	figure	figure	NOUN
admet-387	25	6	1	1	NUM
admet-387	25	7	.	.	PUNCT
admet-387	26	1	organization	organization	NOUN
admet-387	26	2	of	of	ADP
admet-387	26	3	urate	urate	NOUN
admet-387	26	4	transporters	transporter	NOUN
admet-387	26	5	in	in	ADP
admet-387	26	6	polarized	polarize	VERB
admet-387	26	7	epithelial	epithelial	ADJ
admet-387	26	8	cells	cell	NOUN
admet-387	26	9	of	of	ADP
admet-387	26	10	the	the	DET
admet-387	26	11	kidney	kidney	NOUN
admet-387	26	12	(	(	PUNCT
admet-387	26	13	a	a	NOUN
admet-387	26	14	)	)	PUNCT
admet-387	26	15	and	and	CCONJ
admet-387	26	16	intestine	intestine	NOUN
admet-387	26	17	(	(	PUNCT
admet-387	26	18	b	b	NOUN
admet-387	26	19	)	)	PUNCT
admet-387	26	20	.	.	PUNCT
admet-387	27	1	transporters	transporter	NOUN
admet-387	27	2	involved	involve	VERB
admet-387	27	3	in	in	ADP
admet-387	27	4	reabsorption	reabsorption	NOUN
admet-387	27	5	/	/	SYM
admet-387	27	6	absorption	absorption	NOUN
admet-387	27	7	of	of	ADP
admet-387	27	8	urate	urate	NOUN
admet-387	27	9	are	be	AUX
admet-387	27	10	shown	show	VERB
admet-387	27	11	in	in	ADP
admet-387	27	12	green	green	NOUN
admet-387	27	13	,	,	PUNCT
admet-387	27	14	while	while	SCONJ
admet-387	27	15	those	those	PRON
admet-387	27	16	involved	involve	VERB
admet-387	27	17	in	in	ADP
admet-387	27	18	secretion	secretion	NOUN
admet-387	27	19	are	be	AUX
admet-387	27	20	shown	show	VERB
admet-387	27	21	in	in	ADP
admet-387	27	22	red	red	PROPN
admet-387	27	23	.	.	PUNCT
admet-387	28	1	transporters	transporter	NOUN
admet-387	28	2	in	in	ADP
admet-387	28	3	ovals	oval	NOUN
admet-387	28	4	are	be	AUX
admet-387	28	5	genetically	genetically	ADV
admet-387	28	6	-	-	PUNCT
admet-387	28	7	associated	associate	VERB
admet-387	28	8	with	with	ADP
admet-387	28	9	sua	sua	PROPN
admet-387	28	10	levels	level	NOUN
admet-387	28	11	,	,	PUNCT
admet-387	28	12	while	while	SCONJ
admet-387	28	13	transporters	transporter	NOUN
admet-387	28	14	in	in	ADP
admet-387	28	15	boxes	box	NOUN
admet-387	28	16	have	have	VERB
admet-387	28	17	no	no	DET
admet-387	28	18	genetic	genetic	ADJ
admet-387	28	19	association	association	NOUN
admet-387	28	20	with	with	ADP
admet-387	28	21	sua	sua	PROPN
admet-387	28	22	levels	level	NOUN
admet-387	28	23	,	,	PUNCT
admet-387	28	24	but	but	CCONJ
admet-387	28	25	transport	transport	NOUN
admet-387	28	26	urate	urate	NOUN
admet-387	28	27	in	in	ADP
admet-387	28	28	vitro	vitro	X
admet-387	28	29	.	.	PUNCT
admet-387	29	1	specific	specific	ADJ
admet-387	29	2	urate	urate	NOUN
admet-387	29	3	transporters	transporter	NOUN
admet-387	29	4	in	in	ADP
admet-387	29	5	the	the	DET
admet-387	29	6	intestine	intestine	NOUN
admet-387	29	7	,	,	PUNCT
admet-387	29	8	particularly	particularly	ADV
admet-387	29	9	on	on	ADP
admet-387	29	10	the	the	DET
admet-387	29	11	basolateral	basolateral	ADJ
admet-387	29	12	membrane	membrane	NOUN
admet-387	29	13	,	,	PUNCT
admet-387	29	14	are	be	AUX
admet-387	29	15	unknown	unknown	ADJ
admet-387	29	16	.	.	PUNCT
admet-387	30	1	intestinal	intestinal	ADJ
admet-387	30	2	cnt2	cnt2	NOUN
admet-387	30	3	is	be	AUX
admet-387	30	4	involved	involve	VERB
admet-387	30	5	in	in	ADP
admet-387	30	6	import	import	NOUN
admet-387	30	7	of	of	ADP
admet-387	30	8	dietary	dietary	ADJ
admet-387	30	9	purines	purine	NOUN
admet-387	30	10	from	from	ADP
admet-387	30	11	the	the	DET
admet-387	30	12	intestinal	intestinal	ADJ
admet-387	30	13	lumen	luman	NOUN
admet-387	30	14	,	,	PUNCT
admet-387	30	15	which	which	PRON
admet-387	30	16	are	be	AUX
admet-387	30	17	efficiently	efficiently	ADV
admet-387	30	18	metabolized	metabolize	VERB
admet-387	30	19	to	to	ADP
admet-387	30	20	urate	urate	NOUN
admet-387	30	21	by	by	ADP
admet-387	30	22	the	the	DET
admet-387	30	23	enterocytes	enterocyte	NOUN
admet-387	30	24	.	.	PUNCT
admet-387	31	1	admet	admet	PROPN
admet-387	31	2	&	&	CCONJ
admet-387	31	3	dmpk	dmpk	PROPN
admet-387	31	4	5(2	5(2	NUM
admet-387	31	5	)	)	PUNCT
admet-387	31	6	(	(	PUNCT
admet-387	31	7	2017	2017	NUM
admet-387	31	8	)	)	PUNCT
admet-387	31	9	59	59	NUM
admet-387	31	10	-	-	SYM
admet-387	31	11	74	74	NUM
admet-387	31	12	uric	uric	ADJ
admet-387	31	13	acid	acid	NOUN
admet-387	31	14	transporter	transporter	NOUN
admet-387	31	15	inhibitors	inhibitor	NOUN
admet-387	31	16	for	for	ADP
admet-387	31	17	gout	gout	NOUN
admet-387	31	18	doi	doi	NOUN
admet-387	31	19	:	:	PUNCT
admet-387	31	20	10.5599	10.5599	NUM
admet-387	31	21	/	/	SYM
admet-387	31	22	admet.5.1.387	admet.5.1.387	PRON
admet-387	31	23	61	61	NUM
admet-387	31	24	in	in	ADP
admet-387	31	25	the	the	DET
admet-387	31	26	intestine	intestine	NOUN
admet-387	31	27	,	,	PUNCT
admet-387	31	28	uric	uric	ADJ
admet-387	31	29	acid	acid	NOUN
admet-387	31	30	permeability	permeability	NOUN
admet-387	31	31	from	from	ADP
admet-387	31	32	mucosal	mucosal	NOUN
admet-387	31	33	to	to	AUX
admet-387	31	34	serosal	serosal	VERB
admet-387	31	35	(	(	PUNCT
admet-387	31	36	absorption	absorption	NOUN
admet-387	31	37	)	)	PUNCT
admet-387	31	38	and	and	CCONJ
admet-387	31	39	serosal	serosal	NOUN
admet-387	31	40	to	to	ADP
admet-387	31	41	mucosal	mucosal	NOUN
admet-387	31	42	(	(	PUNCT
admet-387	31	43	secretion	secretion	NOUN
admet-387	31	44	)	)	PUNCT
admet-387	31	45	has	have	AUX
admet-387	31	46	been	be	AUX
admet-387	31	47	documented	document	VERB
admet-387	31	48	,	,	PUNCT
admet-387	31	49	but	but	CCONJ
admet-387	31	50	the	the	DET
admet-387	31	51	identities	identity	NOUN
admet-387	31	52	of	of	ADP
admet-387	31	53	the	the	DET
admet-387	31	54	responsible	responsible	ADJ
admet-387	31	55	transporters	transporter	NOUN
admet-387	31	56	in	in	ADP
admet-387	31	57	humans	human	NOUN
admet-387	31	58	are	be	AUX
admet-387	31	59	,	,	PUNCT
admet-387	31	60	for	for	ADP
admet-387	31	61	the	the	DET
admet-387	31	62	most	most	ADJ
admet-387	31	63	part	part	NOUN
admet-387	31	64	,	,	PUNCT
admet-387	31	65	unknown	unknown	ADJ
admet-387	31	66	(	(	PUNCT
admet-387	31	67	figure	figure	NOUN
admet-387	31	68	1b	1b	NUM
admet-387	31	69	)	)	PUNCT
admet-387	31	70	.	.	PUNCT
admet-387	32	1	the	the	DET
admet-387	32	2	important	important	ADJ
admet-387	32	3	drug	drug	NOUN
admet-387	32	4	transporter	transporter	NOUN
admet-387	32	5	breast	breast	NOUN
admet-387	32	6	cancer	cancer	NOUN
admet-387	32	7	resistance	resistance	NOUN
admet-387	32	8	protein	protein	NOUN
admet-387	32	9	(	(	PUNCT
admet-387	32	10	bcrp	bcrp	ADV
admet-387	32	11	,	,	PUNCT
admet-387	32	12	encoded	encode	VERB
admet-387	32	13	by	by	ADP
admet-387	32	14	the	the	DET
admet-387	32	15	abcg2	abcg2	NOUN
admet-387	32	16	gene	gene	NOUN
admet-387	32	17	)	)	PUNCT
admet-387	32	18	is	be	AUX
admet-387	32	19	highly	highly	ADV
admet-387	32	20	expressed	express	VERB
admet-387	32	21	on	on	ADP
admet-387	32	22	the	the	DET
admet-387	32	23	apical	apical	ADJ
admet-387	32	24	surface	surface	NOUN
admet-387	32	25	of	of	ADP
admet-387	32	26	intestinal	intestinal	ADJ
admet-387	32	27	epithelial	epithelial	ADJ
admet-387	32	28	cells	cell	NOUN
admet-387	32	29	and	and	CCONJ
admet-387	32	30	is	be	AUX
admet-387	32	31	also	also	ADV
admet-387	32	32	an	an	DET
admet-387	32	33	important	important	ADJ
admet-387	32	34	urate	urate	NOUN
admet-387	32	35	transporter	transporter	NOUN
admet-387	32	36	involved	involve	VERB
admet-387	32	37	in	in	ADP
admet-387	32	38	intestinal	intestinal	ADJ
admet-387	32	39	urate	urate	NOUN
admet-387	32	40	secretion	secretion	NOUN
admet-387	33	1	[	[	X
admet-387	33	2	9	9	NUM
admet-387	33	3	-	-	SYM
admet-387	33	4	12	12	NUM
admet-387	33	5	]	]	PUNCT
admet-387	33	6	.	.	PUNCT
admet-387	34	1	dietary	dietary	ADJ
admet-387	34	2	purines	purine	NOUN
admet-387	34	3	are	be	AUX
admet-387	34	4	imported	import	VERB
admet-387	34	5	from	from	ADP
admet-387	34	6	the	the	DET
admet-387	34	7	lumen	luman	NOUN
admet-387	34	8	of	of	ADP
admet-387	34	9	intestinal	intestinal	ADJ
admet-387	34	10	enterocytes	enterocyte	NOUN
admet-387	34	11	by	by	ADP
admet-387	34	12	the	the	DET
admet-387	34	13	nucleoside	nucleoside	ADJ
admet-387	34	14	transporter	transporter	NOUN
admet-387	34	15	cnt2	cnt2	NOUN
admet-387	34	16	/	/	SYM
admet-387	34	17	slc28a2	slc28a2	PROPN
admet-387	34	18	,	,	PUNCT
admet-387	34	19	which	which	PRON
admet-387	34	20	are	be	AUX
admet-387	34	21	then	then	ADV
admet-387	34	22	converted	convert	VERB
admet-387	34	23	to	to	ADP
admet-387	34	24	uric	uric	ADJ
admet-387	34	25	acid	acid	NOUN
admet-387	34	26	by	by	ADP
admet-387	34	27	intestinal	intestinal	ADJ
admet-387	34	28	xanthine	xanthine	NOUN
admet-387	34	29	oxidase	oxidase	NOUN
admet-387	34	30	.	.	PUNCT
admet-387	35	1	inhibitors	inhibitor	NOUN
admet-387	35	2	of	of	ADP
admet-387	35	3	cnt2	cnt2	NOUN
admet-387	35	4	have	have	AUX
admet-387	35	5	been	be	AUX
admet-387	35	6	shown	show	VERB
admet-387	35	7	to	to	PART
admet-387	35	8	reduce	reduce	VERB
admet-387	35	9	sua	sua	PROPN
admet-387	35	10	levels	level	NOUN
admet-387	35	11	in	in	ADP
admet-387	35	12	non	non	ADJ
admet-387	35	13	-	-	ADJ
admet-387	35	14	human	human	ADJ
admet-387	35	15	primates	primate	NOUN
admet-387	35	16	and	and	CCONJ
admet-387	35	17	are	be	AUX
admet-387	35	18	therefore	therefore	ADV
admet-387	35	19	possible	possible	ADJ
admet-387	35	20	candidates	candidate	NOUN
admet-387	35	21	for	for	ADP
admet-387	35	22	new	new	ADJ
admet-387	35	23	urate	urate	NOUN
admet-387	35	24	-	-	PUNCT
admet-387	35	25	lowering	lower	VERB
admet-387	35	26	therapies	therapy	NOUN
admet-387	35	27	[	[	X
admet-387	35	28	13	13	NUM
admet-387	35	29	]	]	PUNCT
admet-387	35	30	.	.	PUNCT
admet-387	36	1	the	the	DET
admet-387	36	2	chronically	chronically	ADV
admet-387	36	3	elevated	elevated	ADJ
admet-387	36	4	concentrations	concentration	NOUN
admet-387	36	5	of	of	ADP
admet-387	36	6	sua	sua	NOUN
admet-387	36	7	in	in	ADP
admet-387	36	8	gout	gout	NOUN
admet-387	36	9	patients	patient	NOUN
admet-387	36	10	are	be	AUX
admet-387	36	11	caused	cause	VERB
admet-387	36	12	by	by	ADP
admet-387	36	13	increased	increase	VERB
admet-387	36	14	uric	uric	ADJ
admet-387	36	15	acid	acid	NOUN
admet-387	36	16	production	production	NOUN
admet-387	36	17	,	,	PUNCT
admet-387	36	18	decreased	decrease	VERB
admet-387	36	19	uric	uric	ADJ
admet-387	36	20	acid	acid	NOUN
admet-387	36	21	elimination	elimination	NOUN
admet-387	36	22	,	,	PUNCT
admet-387	36	23	or	or	CCONJ
admet-387	36	24	a	a	DET
admet-387	36	25	combination	combination	NOUN
admet-387	36	26	of	of	ADP
admet-387	36	27	the	the	DET
admet-387	36	28	two	two	NUM
admet-387	36	29	.	.	PUNCT
admet-387	37	1	in	in	ADP
admet-387	37	2	most	most	ADJ
admet-387	37	3	gout	gout	NOUN
admet-387	37	4	patients	patient	NOUN
admet-387	37	5	,	,	PUNCT
admet-387	37	6	high	high	ADJ
admet-387	37	7	sua	sua	PROPN
admet-387	37	8	levels	level	NOUN
admet-387	37	9	are	be	AUX
admet-387	37	10	due	due	ADJ
admet-387	37	11	to	to	AUX
admet-387	37	12	decreased	decrease	VERB
admet-387	37	13	uric	uric	ADJ
admet-387	37	14	acid	acid	NOUN
admet-387	37	15	elimination	elimination	NOUN
admet-387	37	16	in	in	ADP
admet-387	37	17	the	the	DET
admet-387	37	18	kidneys	kidney	NOUN
admet-387	37	19	,	,	PUNCT
admet-387	37	20	recently	recently	ADV
admet-387	37	21	confirmed	confirm	VERB
admet-387	37	22	with	with	ADP
admet-387	37	23	clinical	clinical	ADJ
admet-387	37	24	trial	trial	NOUN
admet-387	37	25	results	result	NOUN
admet-387	37	26	[	[	X
admet-387	37	27	14	14	NUM
admet-387	37	28	]	]	PUNCT
admet-387	37	29	.	.	PUNCT
admet-387	38	1	we	we	PRON
admet-387	38	2	also	also	ADV
admet-387	38	3	discovered	discover	VERB
admet-387	38	4	that	that	SCONJ
admet-387	38	5	gout	gout	NOUN
admet-387	38	6	patients	patient	NOUN
admet-387	38	7	have	have	VERB
admet-387	38	8	an	an	DET
admet-387	38	9	altered	alter	VERB
admet-387	38	10	renal	renal	ADJ
admet-387	38	11	urate	urate	NOUN
admet-387	38	12	reabsorption	reabsorption	NOUN
admet-387	38	13	profile	profile	NOUN
admet-387	38	14	in	in	ADP
admet-387	38	15	response	response	NOUN
admet-387	38	16	to	to	ADP
admet-387	38	17	xoi	xoi	NOUN
admet-387	38	18	urate	urate	NOUN
admet-387	38	19	lowering	lower	VERB
admet-387	38	20	therapies	therapy	NOUN
admet-387	38	21	,	,	PUNCT
admet-387	38	22	relative	relative	ADJ
admet-387	38	23	to	to	ADP
admet-387	38	24	healthy	healthy	ADJ
admet-387	38	25	individuals	individual	NOUN
admet-387	38	26	.	.	PUNCT
admet-387	39	1	these	these	DET
admet-387	39	2	differences	difference	NOUN
admet-387	39	3	in	in	ADP
admet-387	39	4	the	the	DET
admet-387	39	5	renal	renal	ADJ
admet-387	39	6	urate	urate	NOUN
admet-387	39	7	reabsorption	reabsorption	NOUN
admet-387	39	8	in	in	ADP
admet-387	39	9	gout	gout	NOUN
admet-387	39	10	patients	patient	NOUN
admet-387	39	11	are	be	AUX
admet-387	39	12	likely	likely	ADJ
admet-387	39	13	due	due	ADP
admet-387	39	14	to	to	ADP
admet-387	39	15	differences	difference	NOUN
admet-387	39	16	in	in	ADP
admet-387	39	17	the	the	DET
admet-387	39	18	activities	activity	NOUN
admet-387	39	19	of	of	ADP
admet-387	39	20	renal	renal	ADJ
admet-387	39	21	urate	urate	NOUN
admet-387	39	22	transporters	transporter	NOUN
admet-387	39	23	.	.	PUNCT
admet-387	40	1	it	it	PRON
admet-387	40	2	is	be	AUX
admet-387	40	3	possible	possible	ADJ
admet-387	40	4	that	that	SCONJ
admet-387	40	5	transporters	transporter	NOUN
admet-387	40	6	involved	involve	VERB
admet-387	40	7	in	in	ADP
admet-387	40	8	reabsorption	reabsorption	NOUN
admet-387	40	9	(	(	PUNCT
admet-387	40	10	colored	color	VERB
admet-387	40	11	green	green	ADJ
admet-387	40	12	in	in	ADP
admet-387	40	13	figure	figure	NOUN
admet-387	40	14	1a	1a	NOUN
admet-387	40	15	)	)	PUNCT
admet-387	40	16	are	be	AUX
admet-387	40	17	more	more	ADV
admet-387	40	18	active	active	ADJ
admet-387	40	19	,	,	PUNCT
admet-387	40	20	leading	lead	VERB
admet-387	40	21	to	to	ADP
admet-387	40	22	enhanced	enhanced	ADJ
admet-387	40	23	reabsorption	reabsorption	NOUN
admet-387	40	24	of	of	ADP
admet-387	40	25	urate	urate	NOUN
admet-387	40	26	,	,	PUNCT
admet-387	40	27	or	or	CCONJ
admet-387	40	28	that	that	SCONJ
admet-387	40	29	transporters	transporter	NOUN
admet-387	40	30	involved	involve	VERB
admet-387	40	31	in	in	ADP
admet-387	40	32	urate	urate	NOUN
admet-387	40	33	secretion	secretion	NOUN
admet-387	40	34	(	(	PUNCT
admet-387	40	35	colored	color	VERB
admet-387	40	36	red	red	ADJ
admet-387	40	37	in	in	ADP
admet-387	40	38	figure	figure	NOUN
admet-387	40	39	1a	1a	NOUN
admet-387	40	40	)	)	PUNCT
admet-387	40	41	are	be	AUX
admet-387	40	42	less	less	ADV
admet-387	40	43	active	active	ADJ
admet-387	40	44	,	,	PUNCT
admet-387	40	45	or	or	CCONJ
admet-387	40	46	some	some	DET
admet-387	40	47	combination	combination	NOUN
admet-387	40	48	of	of	ADP
admet-387	40	49	the	the	DET
admet-387	40	50	above	above	ADJ
admet-387	40	51	two	two	NUM
admet-387	40	52	scenarios	scenario	NOUN
admet-387	40	53	[	[	X
admet-387	40	54	14	14	NUM
admet-387	40	55	]	]	PUNCT
admet-387	40	56	.	.	PUNCT
admet-387	41	1	it	it	PRON
admet-387	41	2	is	be	AUX
admet-387	41	3	also	also	ADV
admet-387	41	4	now	now	ADV
admet-387	41	5	known	know	VERB
admet-387	41	6	that	that	SCONJ
admet-387	41	7	many	many	ADJ
admet-387	41	8	drugs	drug	NOUN
admet-387	41	9	and	and	CCONJ
admet-387	41	10	metabolic	metabolic	NOUN
admet-387	41	11	anomalies	anomaly	NOUN
admet-387	41	12	increase	increase	VERB
admet-387	41	13	or	or	CCONJ
admet-387	41	14	decrease	decrease	VERB
admet-387	41	15	sua	sua	NOUN
admet-387	41	16	levels	level	NOUN
admet-387	41	17	by	by	ADP
admet-387	41	18	altering	alter	VERB
admet-387	41	19	the	the	DET
admet-387	41	20	activities	activity	NOUN
admet-387	41	21	of	of	ADP
admet-387	41	22	urate	urate	NOUN
admet-387	41	23	transporters	transporter	NOUN
admet-387	41	24	,	,	PUNCT
admet-387	41	25	and	and	CCONJ
admet-387	41	26	this	this	PRON
admet-387	41	27	is	be	AUX
admet-387	41	28	explained	explain	VERB
admet-387	41	29	in	in	ADP
admet-387	41	30	the	the	DET
admet-387	41	31	following	follow	VERB
admet-387	41	32	section	section	NOUN
admet-387	41	33	.	.	PUNCT
admet-387	42	1	uric	uric	ADJ
admet-387	42	2	acid	acid	PROPN
admet-387	42	3	transporters	transporter	NOUN
admet-387	42	4	and	and	CCONJ
admet-387	42	5	drug	drug	NOUN
admet-387	42	6	interactions	interaction	NOUN
admet-387	42	7	urat1	urat1	ADP
admet-387	43	1	the	the	DET
admet-387	43	2	renal	renal	ADJ
admet-387	43	3	uric	uric	ADJ
admet-387	43	4	acid	acid	NOUN
admet-387	43	5	transporter	transporter	NOUN
admet-387	43	6	type	type	NOUN
admet-387	43	7	1	1	NUM
admet-387	43	8	(	(	PUNCT
admet-387	43	9	urat1	urat1	NOUN
admet-387	43	10	/	/	SYM
admet-387	43	11	slc22a12	slc22a12	NOUN
admet-387	43	12	)	)	PUNCT
admet-387	43	13	is	be	AUX
admet-387	43	14	expressed	express	VERB
admet-387	43	15	on	on	ADP
admet-387	43	16	the	the	DET
admet-387	43	17	apical	apical	ADJ
admet-387	43	18	membranes	membrane	NOUN
admet-387	43	19	of	of	ADP
admet-387	43	20	renal	renal	ADJ
admet-387	43	21	proximal	proximal	ADJ
admet-387	43	22	tubule	tubule	NOUN
admet-387	43	23	epithelial	epithelial	ADJ
admet-387	43	24	cells	cell	NOUN
admet-387	43	25	(	(	PUNCT
admet-387	43	26	rptecs	rptec	NOUN
admet-387	43	27	)	)	PUNCT
admet-387	43	28	and	and	CCONJ
admet-387	43	29	is	be	AUX
admet-387	43	30	required	require	VERB
admet-387	43	31	for	for	ADP
admet-387	43	32	the	the	DET
admet-387	43	33	first	first	ADJ
admet-387	43	34	step	step	NOUN
admet-387	43	35	in	in	ADP
admet-387	43	36	reabsorption	reabsorption	NOUN
admet-387	43	37	of	of	ADP
admet-387	43	38	uric	uric	ADJ
admet-387	43	39	acid	acid	NOUN
admet-387	43	40	from	from	ADP
admet-387	43	41	the	the	DET
admet-387	43	42	lumen	luman	NOUN
admet-387	43	43	of	of	ADP
admet-387	43	44	the	the	DET
admet-387	43	45	proximal	proximal	ADJ
admet-387	43	46	tubule	tubule	NOUN
admet-387	43	47	to	to	ADP
admet-387	43	48	the	the	DET
admet-387	43	49	bloodstream	bloodstream	NOUN
admet-387	43	50	(	(	PUNCT
admet-387	43	51	figure	figure	NOUN
admet-387	43	52	1a	1a	NOUN
admet-387	43	53	)	)	PUNCT
admet-387	43	54	.	.	PUNCT
admet-387	44	1	individuals	individual	NOUN
admet-387	44	2	carrying	carry	VERB
admet-387	44	3	inactivating	inactivate	VERB
admet-387	44	4	mutations	mutation	NOUN
admet-387	44	5	of	of	ADP
admet-387	44	6	urat1	urat1	NOUN
admet-387	44	7	have	have	VERB
admet-387	44	8	high	high	ADJ
admet-387	44	9	levels	level	NOUN
admet-387	44	10	of	of	ADP
admet-387	44	11	urinary	urinary	ADJ
admet-387	44	12	uric	uric	ADJ
admet-387	44	13	acid	acid	NOUN
admet-387	44	14	excretion	excretion	NOUN
admet-387	44	15	and	and	CCONJ
admet-387	44	16	low	low	ADJ
admet-387	44	17	levels	level	NOUN
admet-387	44	18	of	of	ADP
admet-387	44	19	sua	sua	PROPN
admet-387	44	20	(	(	PUNCT
admet-387	44	21	renal	renal	PROPN
admet-387	44	22	hypouricemia	hypouricemia	NOUN
admet-387	44	23	)	)	PUNCT
admet-387	44	24	due	due	ADP
admet-387	44	25	to	to	ADP
admet-387	44	26	reduced	reduce	VERB
admet-387	44	27	uric	uric	ADJ
admet-387	44	28	acid	acid	NOUN
admet-387	44	29	reabsorption	reabsorption	NOUN
admet-387	44	30	from	from	ADP
admet-387	44	31	the	the	DET
admet-387	44	32	proximal	proximal	ADJ
admet-387	44	33	tubules	tubule	NOUN
admet-387	44	34	,	,	PUNCT
admet-387	44	35	showing	show	VERB
admet-387	44	36	that	that	SCONJ
admet-387	44	37	urat1	urat1	PROPN
admet-387	44	38	is	be	AUX
admet-387	44	39	essential	essential	ADJ
admet-387	44	40	for	for	ADP
admet-387	44	41	efficient	efficient	ADJ
admet-387	44	42	renal	renal	ADJ
admet-387	44	43	reabsorption	reabsorption	NOUN
admet-387	44	44	of	of	ADP
admet-387	44	45	uric	uric	ADJ
admet-387	44	46	acid	acid	NOUN
admet-387	45	1	[	[	X
admet-387	45	2	15	15	NUM
admet-387	45	3	]	]	PUNCT
admet-387	45	4	.	.	PUNCT
admet-387	46	1	the	the	DET
admet-387	46	2	uricosuric	uricosuric	ADJ
admet-387	46	3	class	class	NOUN
admet-387	46	4	of	of	ADP
admet-387	46	5	urate	urate	NOUN
admet-387	46	6	-	-	PUNCT
admet-387	46	7	lowering	lower	VERB
admet-387	46	8	therapies	therapy	NOUN
admet-387	46	9	(	(	PUNCT
admet-387	46	10	lesinurad	lesinurad	PROPN
admet-387	46	11	,	,	PUNCT
admet-387	46	12	probenecid	probenecid	PROPN
admet-387	46	13	,	,	PUNCT
admet-387	46	14	and	and	CCONJ
admet-387	46	15	benzbromarone	benzbromarone	NOUN
admet-387	46	16	)	)	PUNCT
admet-387	46	17	for	for	ADP
admet-387	46	18	the	the	DET
admet-387	46	19	treatment	treatment	NOUN
admet-387	46	20	of	of	ADP
admet-387	46	21	gout	gout	NOUN
admet-387	46	22	lower	low	ADJ
admet-387	46	23	sua	sua	PROPN
admet-387	46	24	concentrations	concentration	NOUN
admet-387	46	25	by	by	ADP
admet-387	46	26	inhibiting	inhibit	VERB
admet-387	46	27	urat1	urat1	NOUN
admet-387	46	28	.	.	PUNCT
admet-387	47	1	other	other	ADJ
admet-387	47	2	drugs	drug	NOUN
admet-387	47	3	indicated	indicate	VERB
admet-387	47	4	primarily	primarily	ADV
admet-387	47	5	for	for	ADP
admet-387	47	6	other	other	ADJ
admet-387	47	7	therapies	therapy	NOUN
admet-387	47	8	(	(	PUNCT
admet-387	47	9	losartan	losartan	ADJ
admet-387	47	10	,	,	PUNCT
admet-387	47	11	hypertension	hypertension	NOUN
admet-387	47	12	;	;	PUNCT
admet-387	47	13	fenofibrate	fenofibrate	NOUN
admet-387	47	14	,	,	PUNCT
admet-387	47	15	hyperlipidemia	hyperlipidemia	NOUN
admet-387	47	16	)	)	PUNCT
admet-387	47	17	are	be	AUX
admet-387	47	18	considered	consider	VERB
admet-387	47	19	secondary	secondary	ADJ
admet-387	47	20	uricosurics	uricosuric	NOUN
admet-387	47	21	because	because	SCONJ
admet-387	47	22	they	they	PRON
admet-387	47	23	also	also	ADV
admet-387	47	24	inhibit	inhibit	VERB
admet-387	47	25	urat1	urat1	NOUN
admet-387	48	1	[	[	X
admet-387	48	2	16	16	NUM
admet-387	48	3	,	,	PUNCT
admet-387	48	4	17	17	NUM
admet-387	48	5	]	]	PUNCT
admet-387	48	6	.	.	PUNCT
admet-387	49	1	urat1	urat1	PROPN
admet-387	49	2	is	be	AUX
admet-387	49	3	a	a	DET
admet-387	49	4	member	member	NOUN
admet-387	49	5	of	of	ADP
admet-387	49	6	the	the	DET
admet-387	49	7	organic	organic	ADJ
admet-387	49	8	anion	anion	NOUN
admet-387	49	9	transporter	transporter	NOUN
admet-387	49	10	(	(	PUNCT
admet-387	49	11	oat	oat	NOUN
admet-387	49	12	)	)	PUNCT
admet-387	49	13	subtype	subtype	NOUN
admet-387	49	14	of	of	ADP
admet-387	49	15	solute	solute	NOUN
admet-387	49	16	carrier	carrier	NOUN
admet-387	49	17	(	(	PUNCT
admet-387	49	18	slc	slc	PROPN
admet-387	49	19	)	)	PUNCT
admet-387	49	20	type	type	NOUN
admet-387	49	21	22a	22a	NUM
admet-387	49	22	family	family	NOUN
admet-387	49	23	(	(	PUNCT
admet-387	49	24	slc22a	slc22a	PROPN
admet-387	49	25	)	)	PUNCT
admet-387	49	26	of	of	ADP
admet-387	49	27	transporters	transporter	NOUN
admet-387	49	28	,	,	PUNCT
admet-387	49	29	which	which	PRON
admet-387	49	30	typically	typically	ADV
admet-387	49	31	function	function	VERB
admet-387	49	32	as	as	ADP
admet-387	49	33	organic	organic	ADJ
admet-387	49	34	anion	anion	NOUN
admet-387	49	35	exchangers	exchanger	NOUN
admet-387	49	36	.	.	PUNCT
admet-387	50	1	specifically	specifically	ADV
admet-387	50	2	,	,	PUNCT
admet-387	50	3	urat1	urat1	NOUN
admet-387	50	4	imports	import	NOUN
admet-387	50	5	urate	urate	VERB
admet-387	50	6	in	in	ADP
admet-387	50	7	exchange	exchange	NOUN
admet-387	50	8	for	for	ADP
admet-387	50	9	export	export	NOUN
admet-387	50	10	of	of	ADP
admet-387	50	11	small	small	ADJ
admet-387	50	12	anionic	anionic	ADJ
admet-387	50	13	counterions	counterion	NOUN
admet-387	50	14	such	such	ADJ
admet-387	50	15	as	as	ADP
admet-387	50	16	lactate	lactate	NOUN
admet-387	50	17	(	(	PUNCT
admet-387	50	18	figure	figure	NOUN
admet-387	50	19	2	2	NUM
admet-387	50	20	)	)	PUNCT
admet-387	50	21	.	.	PUNCT
admet-387	51	1	the	the	DET
admet-387	51	2	activity	activity	NOUN
admet-387	51	3	of	of	ADP
admet-387	51	4	urat1	urat1	NOUN
admet-387	51	5	depends	depend	VERB
admet-387	51	6	on	on	ADP
admet-387	51	7	these	these	DET
admet-387	51	8	counterions	counterion	NOUN
admet-387	51	9	,	,	PUNCT
admet-387	51	10	and	and	CCONJ
admet-387	51	11	certain	certain	ADJ
admet-387	51	12	pathophysiological	pathophysiological	ADJ
admet-387	51	13	conditions	condition	NOUN
admet-387	51	14	and	and	CCONJ
admet-387	51	15	drugs	drug	NOUN
admet-387	51	16	alter	alter	VERB
admet-387	51	17	sua	sua	PROPN
admet-387	51	18	levels	level	NOUN
admet-387	51	19	by	by	ADP
admet-387	51	20	altering	alter	VERB
admet-387	51	21	the	the	DET
admet-387	51	22	activity	activity	NOUN
admet-387	51	23	of	of	ADP
admet-387	51	24	urat1	urat1	PROPN
admet-387	51	25	.	.	PUNCT
admet-387	52	1	increased	increase	VERB
admet-387	52	2	concentrations	concentration	NOUN
admet-387	52	3	of	of	ADP
admet-387	52	4	counterions	counterion	NOUN
admet-387	52	5	can	can	AUX
admet-387	52	6	stimulate	stimulate	VERB
admet-387	52	7	the	the	DET
admet-387	52	8	counterion	counterion	NOUN
admet-387	52	9	transport	transport	NOUN
admet-387	52	10	of	of	ADP
admet-387	52	11	urat1	urat1	PROPN
admet-387	52	12	,	,	PUNCT
admet-387	52	13	leading	lead	VERB
admet-387	52	14	to	to	ADP
admet-387	52	15	increased	increase	VERB
admet-387	52	16	uric	uric	ADJ
admet-387	52	17	acid	acid	NOUN
admet-387	52	18	transport	transport	NOUN
admet-387	52	19	of	of	ADP
admet-387	52	20	urat1	urat1	NOUN
admet-387	52	21	in	in	ADP
admet-387	52	22	a	a	DET
admet-387	52	23	process	process	NOUN
admet-387	52	24	called	call	VERB
admet-387	52	25	trans	tran	NOUN
admet-387	52	26	-	-	NOUN
admet-387	52	27	stimulation	stimulation	NOUN
admet-387	52	28	.	.	PUNCT
admet-387	53	1	alcohol	alcohol	NOUN
admet-387	53	2	poisoning	poisoning	NOUN
admet-387	53	3	(	(	PUNCT
admet-387	53	4	lactic	lactic	ADJ
admet-387	53	5	acidosis	acidosis	NOUN
admet-387	53	6	)	)	PUNCT
admet-387	53	7	and	and	CCONJ
admet-387	53	8	diabetic	diabetic	ADJ
admet-387	53	9	ketoacidosis	ketoacidosis	NOUN
admet-387	53	10	elevate	elevate	VERB
admet-387	53	11	sua	sua	PROPN
admet-387	53	12	levels	level	NOUN
admet-387	53	13	due	due	ADP
admet-387	53	14	to	to	ADP
admet-387	53	15	elevated	elevated	ADJ
admet-387	53	16	levels	level	NOUN
admet-387	53	17	of	of	ADP
admet-387	53	18	the	the	DET
admet-387	53	19	urat1	urat1	PROPN
admet-387	53	20	counterions	counterion	NOUN
admet-387	53	21	lactate	lactate	NOUN
admet-387	53	22	and	and	CCONJ
admet-387	53	23	ketoacids	ketoacid	NOUN
admet-387	53	24	(	(	PUNCT
admet-387	53	25	acetoacetate	acetoacetate	NOUN
admet-387	53	26	and	and	CCONJ
admet-387	53	27	β	β	NOUN
admet-387	53	28	-	-	NOUN
admet-387	53	29	hydroxybutyrate	hydroxybutyrate	NOUN
admet-387	53	30	)	)	PUNCT
admet-387	53	31	,	,	PUNCT
admet-387	53	32	respectively	respectively	ADV
admet-387	53	33	[	[	X
admet-387	53	34	18	18	NUM
admet-387	53	35	,	,	PUNCT
admet-387	53	36	19	19	NUM
admet-387	53	37	]	]	PUNCT
admet-387	53	38	.	.	PUNCT
admet-387	54	1	furthermore	furthermore	ADV
admet-387	54	2	,	,	PUNCT
admet-387	54	3	salicylate	salicylate	NOUN
admet-387	54	4	(	(	PUNCT
admet-387	54	5	at	at	ADP
admet-387	54	6	low	low	ADJ
admet-387	54	7	doses	dose	NOUN
admet-387	54	8	)	)	PUNCT
admet-387	54	9	,	,	PUNCT
admet-387	54	10	niacin	niacin	NOUN
admet-387	54	11	or	or	CCONJ
admet-387	54	12	nicotinate	nicotinate	NOUN
admet-387	54	13	(	(	PUNCT
admet-387	54	14	for	for	ADP
admet-387	54	15	treatment	treatment	NOUN
admet-387	54	16	of	of	ADP
admet-387	54	17	hyperlipidemia	hyperlipidemia	NOUN
admet-387	54	18	)	)	PUNCT
admet-387	54	19	,	,	PUNCT
admet-387	54	20	and	and	CCONJ
admet-387	54	21	pyrazinoate	pyrazinoate	NOUN
admet-387	54	22	(	(	PUNCT
admet-387	54	23	the	the	DET
admet-387	54	24	primary	primary	ADJ
admet-387	54	25	metabolite	metabolite	NOUN
admet-387	54	26	of	of	ADP
admet-387	54	27	the	the	DET
admet-387	54	28	tuberculosis	tuberculosis	NOUN
admet-387	54	29	therapy	therapy	NOUN
admet-387	54	30	pyrazinamide	pyrazinamide	NOUN
admet-387	54	31	)	)	PUNCT
admet-387	54	32	function	function	NOUN
admet-387	54	33	as	as	ADP
admet-387	54	34	pharmacological	pharmacological	NOUN
admet-387	54	35	urat1	urat1	NOUN
admet-387	54	36	counterions	counterion	NOUN
admet-387	54	37	and	and	CCONJ
admet-387	54	38	also	also	ADV
admet-387	54	39	elevate	elevate	VERB
admet-387	54	40	sua	sua	PROPN
admet-387	54	41	levels	level	NOUN
admet-387	54	42	through	through	ADP
admet-387	54	43	trans	tran	NOUN
admet-387	54	44	-	-	NOUN
admet-387	54	45	stimulation	stimulation	NOUN
admet-387	54	46	of	of	ADP
admet-387	54	47	urat1	urat1	PROPN
admet-387	54	48	.	.	PUNCT
admet-387	55	1	high	high	ADJ
admet-387	55	2	doses	dose	NOUN
admet-387	55	3	of	of	ADP
admet-387	55	4	tan	tan	PROPN
admet-387	55	5	and	and	CCONJ
admet-387	55	6	miner	miner	NOUN
admet-387	55	7	admet	admet	PROPN
admet-387	55	8	&	&	CCONJ
admet-387	55	9	dmpk	dmpk	PROPN
admet-387	55	10	5(2	5(2	NUM
admet-387	55	11	)	)	PUNCT
admet-387	55	12	(	(	PUNCT
admet-387	55	13	2017	2017	NUM
admet-387	55	14	)	)	PUNCT
admet-387	55	15	59	59	NUM
admet-387	55	16	-	-	SYM
admet-387	55	17	74	74	NUM
admet-387	55	18	62	62	NUM
admet-387	55	19	salicylate	salicylate	NOUN
admet-387	55	20	,	,	PUNCT
admet-387	55	21	on	on	ADP
admet-387	55	22	the	the	DET
admet-387	55	23	other	other	ADJ
admet-387	55	24	hand	hand	NOUN
admet-387	55	25	,	,	PUNCT
admet-387	55	26	inhibit	inhibit	VERB
admet-387	55	27	the	the	DET
admet-387	55	28	urate	urate	NOUN
admet-387	55	29	transport	transport	NOUN
admet-387	55	30	activity	activity	NOUN
admet-387	55	31	of	of	ADP
admet-387	55	32	urat1	urat1	NOUN
admet-387	55	33	(	(	PUNCT
admet-387	55	34	cis	cis	NOUN
admet-387	55	35	-	-	PUNCT
admet-387	55	36	inhibition	inhibition	NOUN
admet-387	55	37	)	)	PUNCT
admet-387	55	38	to	to	PART
admet-387	55	39	lower	low	ADJ
admet-387	55	40	sua	sua	PROPN
admet-387	55	41	levels	level	NOUN
admet-387	55	42	.	.	PUNCT
admet-387	56	1	therefore	therefore	ADV
admet-387	56	2	,	,	PUNCT
admet-387	56	3	the	the	DET
admet-387	56	4	paradoxical	paradoxical	ADJ
admet-387	56	5	effect	effect	NOUN
admet-387	56	6	of	of	ADP
admet-387	56	7	salicylate	salicylate	ADJ
admet-387	56	8	dosage	dosage	NOUN
admet-387	56	9	on	on	ADP
admet-387	56	10	sua	sua	PROPN
admet-387	56	11	levels	level	NOUN
admet-387	56	12	is	be	AUX
admet-387	56	13	explained	explain	VERB
admet-387	56	14	through	through	ADP
admet-387	56	15	different	different	ADJ
admet-387	56	16	dose	dose	NOUN
admet-387	56	17	-	-	PUNCT
admet-387	56	18	dependent	dependent	ADJ
admet-387	56	19	interactions	interaction	NOUN
admet-387	56	20	with	with	ADP
admet-387	56	21	urat1	urat1	PROPN
admet-387	56	22	.	.	PUNCT
admet-387	56	23	figure	figure	NOUN
admet-387	57	1	2	2	NUM
admet-387	57	2	.	.	PUNCT
admet-387	57	3	effects	effect	NOUN
admet-387	57	4	of	of	ADP
admet-387	57	5	xenobiotics	xenobiotics	PROPN
admet-387	57	6	and	and	CCONJ
admet-387	57	7	endobiotics	endobiotic	NOUN
admet-387	57	8	on	on	ADP
admet-387	57	9	urate	urate	NOUN
admet-387	57	10	transport	transport	NOUN
admet-387	57	11	in	in	ADP
admet-387	57	12	the	the	DET
admet-387	57	13	kidney	kidney	NOUN
admet-387	57	14	proximal	proximal	ADJ
admet-387	57	15	tubule	tubule	NOUN
admet-387	57	16	.	.	PUNCT
admet-387	58	1	for	for	ADP
admet-387	58	2	each	each	DET
admet-387	58	3	transporter	transporter	NOUN
admet-387	58	4	,	,	PUNCT
admet-387	58	5	endogenous	endogenous	ADJ
admet-387	58	6	substrates	substrate	NOUN
admet-387	58	7	are	be	AUX
admet-387	58	8	in	in	ADP
admet-387	58	9	normal	normal	ADJ
admet-387	58	10	case	case	NOUN
admet-387	58	11	,	,	PUNCT
admet-387	58	12	while	while	SCONJ
admet-387	58	13	drugs	drug	NOUN
admet-387	58	14	are	be	AUX
admet-387	58	15	in	in	ADP
admet-387	58	16	bold	bold	ADJ
admet-387	58	17	(	(	PUNCT
admet-387	58	18	nicotinate	nicotinate	NOUN
admet-387	58	19	is	be	AUX
admet-387	58	20	an	an	DET
admet-387	58	21	endogenous	endogenous	ADJ
admet-387	58	22	substrate	substrate	NOUN
admet-387	58	23	for	for	ADP
admet-387	58	24	urat1	urat1	NOUN
admet-387	58	25	but	but	CCONJ
admet-387	58	26	is	be	AUX
admet-387	58	27	also	also	ADV
admet-387	58	28	used	use	VERB
admet-387	58	29	as	as	ADP
admet-387	58	30	a	a	DET
admet-387	58	31	therapy	therapy	NOUN
admet-387	58	32	for	for	ADP
admet-387	58	33	hyperlipidemia	hyperlipidemia	NOUN
admet-387	58	34	)	)	PUNCT
admet-387	58	35	.	.	PUNCT
admet-387	59	1	the	the	DET
admet-387	59	2	proposed	propose	VERB
admet-387	59	3	direction	direction	NOUN
admet-387	59	4	of	of	ADP
admet-387	59	5	urate	urate	NOUN
admet-387	59	6	transport	transport	NOUN
admet-387	59	7	is	be	AUX
admet-387	59	8	shown	show	VERB
admet-387	59	9	for	for	ADP
admet-387	59	10	each	each	DET
admet-387	59	11	transporter	transporter	NOUN
admet-387	59	12	.	.	PUNCT
admet-387	60	1	drugs	drug	NOUN
admet-387	60	2	that	that	PRON
admet-387	60	3	stimulate	stimulate	VERB
admet-387	60	4	transport	transport	NOUN
admet-387	60	5	of	of	ADP
admet-387	60	6	urate	urate	NOUN
admet-387	60	7	are	be	AUX
admet-387	60	8	not	not	PART
admet-387	60	9	italicized	italicize	VERB
admet-387	60	10	,	,	PUNCT
admet-387	60	11	while	while	SCONJ
admet-387	60	12	drugs	drug	NOUN
admet-387	60	13	that	that	PRON
admet-387	60	14	inhibit	inhibit	VERB
admet-387	60	15	urate	urate	NOUN
admet-387	60	16	transport	transport	NOUN
admet-387	60	17	are	be	AUX
admet-387	60	18	italicized	italicize	VERB
admet-387	60	19	.	.	PUNCT
admet-387	61	1	see	see	VERB
admet-387	61	2	text	text	NOUN
admet-387	61	3	for	for	ADP
admet-387	61	4	more	more	ADJ
admet-387	61	5	details	detail	NOUN
admet-387	61	6	.	.	PUNCT
admet-387	62	1	α	α	X
admet-387	62	2	-	-	PUNCT
admet-387	62	3	kg	kg	ADJ
admet-387	62	4	,	,	PUNCT
admet-387	62	5	alpha	alpha	NOUN
admet-387	62	6	-	-	PUNCT
admet-387	62	7	ketoglutarate	ketoglutarate	NOUN
admet-387	62	8	.	.	PUNCT
admet-387	63	1	urat1	urat1	PROPN
admet-387	63	2	is	be	AUX
admet-387	63	3	classified	classify	VERB
admet-387	63	4	as	as	ADP
admet-387	63	5	a	a	DET
admet-387	63	6	tertiary	tertiary	ADJ
admet-387	63	7	active	active	ADJ
admet-387	63	8	transporter	transporter	NOUN
admet-387	63	9	,	,	PUNCT
admet-387	63	10	as	as	SCONJ
admet-387	63	11	its	its	PRON
admet-387	63	12	activity	activity	NOUN
admet-387	63	13	is	be	AUX
admet-387	63	14	dependent	dependent	ADJ
admet-387	63	15	on	on	ADP
admet-387	63	16	counterion	counterion	NOUN
admet-387	63	17	and	and	CCONJ
admet-387	63	18	sodium	sodium	NOUN
admet-387	63	19	gradients	gradient	NOUN
admet-387	63	20	generated	generate	VERB
admet-387	63	21	by	by	ADP
admet-387	63	22	secondary	secondary	ADJ
admet-387	63	23	active	active	ADJ
admet-387	63	24	transporters	transporter	NOUN
admet-387	63	25	(	(	PUNCT
admet-387	63	26	na+/monocarboxylate	na+/monocarboxylate	ADP
admet-387	63	27	cotransporters	cotransporter	NOUN
admet-387	63	28	smct1/2	smct1/2	ADJ
admet-387	63	29	)	)	PUNCT
admet-387	63	30	and	and	CCONJ
admet-387	63	31	the	the	DET
admet-387	63	32	primary	primary	ADJ
admet-387	63	33	active	active	ADJ
admet-387	63	34	transporter	transporter	NOUN
admet-387	63	35	(	(	PUNCT
admet-387	63	36	na+/k+	na+/k+	NOUN
admet-387	63	37	atpase	atpase	PROPN
admet-387	63	38	)	)	PUNCT
admet-387	63	39	,	,	PUNCT
admet-387	63	40	respectively	respectively	ADV
admet-387	63	41	(	(	PUNCT
admet-387	63	42	figure	figure	NOUN
admet-387	63	43	3	3	NUM
admet-387	63	44	)	)	PUNCT
admet-387	63	45	.	.	PUNCT
admet-387	64	1	urat1	urat1	PROPN
admet-387	64	2	and	and	CCONJ
admet-387	64	3	smct1/2	smct1/2	PROPN
admet-387	64	4	also	also	ADV
admet-387	64	5	interact	interact	VERB
admet-387	64	6	with	with	ADP
admet-387	64	7	pdzk1	pdzk1	PROPN
admet-387	64	8	,	,	PUNCT
admet-387	64	9	a	a	DET
admet-387	64	10	protein	protein	NOUN
admet-387	64	11	involved	involve	VERB
admet-387	64	12	in	in	ADP
admet-387	64	13	the	the	DET
admet-387	64	14	localization	localization	NOUN
admet-387	64	15	of	of	ADP
admet-387	64	16	apical	apical	ADJ
admet-387	64	17	membrane	membrane	NOUN
admet-387	64	18	proteins	protein	NOUN
admet-387	64	19	in	in	ADP
admet-387	64	20	kidney	kidney	NOUN
admet-387	64	21	and	and	CCONJ
admet-387	64	22	intestinal	intestinal	ADJ
admet-387	64	23	epithelial	epithelial	ADJ
admet-387	64	24	cells	cell	NOUN
admet-387	64	25	.	.	PUNCT
admet-387	65	1	these	these	DET
admet-387	65	2	transporters	transporter	NOUN
admet-387	65	3	,	,	PUNCT
admet-387	65	4	including	include	VERB
admet-387	65	5	many	many	ADJ
admet-387	65	6	other	other	ADJ
admet-387	65	7	urate	urate	NOUN
admet-387	65	8	transporters	transporter	NOUN
admet-387	65	9	,	,	PUNCT
admet-387	65	10	interact	interact	VERB
admet-387	65	11	with	with	ADP
admet-387	65	12	pdzk1	pdzk1	NOUN
admet-387	65	13	through	through	ADP
admet-387	65	14	specific	specific	ADJ
admet-387	65	15	c	c	NOUN
admet-387	65	16	-	-	PUNCT
admet-387	65	17	terminal	terminal	ADJ
admet-387	65	18	binding	bind	VERB
admet-387	65	19	sequences	sequence	NOUN
admet-387	65	20	(	(	PUNCT
admet-387	65	21	table	table	NOUN
admet-387	65	22	1	1	NUM
admet-387	65	23	)	)	PUNCT
admet-387	65	24	.	.	PUNCT
admet-387	66	1	pdzk1	pdzk1	NOUN
admet-387	66	2	has	have	VERB
admet-387	66	3	a	a	DET
admet-387	66	4	strong	strong	ADJ
admet-387	66	5	genetic	genetic	ADJ
admet-387	66	6	association	association	NOUN
admet-387	66	7	with	with	ADP
admet-387	66	8	sua	sua	PROPN
admet-387	66	9	levels	level	NOUN
admet-387	66	10	,	,	PUNCT
admet-387	66	11	suggesting	suggest	VERB
admet-387	66	12	that	that	SCONJ
admet-387	66	13	pdzk1	pdzk1	NOUN
admet-387	66	14	functions	function	NOUN
admet-387	66	15	as	as	ADP
admet-387	66	16	a	a	DET
admet-387	66	17	scaffolding	scaffolding	NOUN
admet-387	66	18	protein	protein	NOUN
admet-387	66	19	to	to	PART
admet-387	66	20	assemble	assemble	VERB
admet-387	66	21	the	the	DET
admet-387	66	22	various	various	ADJ
admet-387	66	23	transporters	transporter	NOUN
admet-387	66	24	into	into	ADP
admet-387	66	25	a	a	DET
admet-387	66	26	“	"	PUNCT
admet-387	66	27	uric	uric	ADJ
admet-387	66	28	acid	acid	NOUN
admet-387	66	29	transportasome	transportasome	NOUN
admet-387	66	30	”	"	PUNCT
admet-387	66	31	for	for	ADP
admet-387	66	32	efficient	efficient	ADJ
admet-387	66	33	control	control	NOUN
admet-387	66	34	of	of	ADP
admet-387	66	35	urate	urate	NOUN
admet-387	66	36	transport	transport	NOUN
admet-387	66	37	and	and	CCONJ
admet-387	66	38	homeostasis	homeostasis	NOUN
admet-387	66	39	(	(	PUNCT
admet-387	66	40	figure	figure	NOUN
admet-387	66	41	3	3	NUM
admet-387	66	42	)	)	PUNCT
admet-387	67	1	[	[	X
admet-387	67	2	20	20	NUM
admet-387	67	3	]	]	PUNCT
admet-387	67	4	.	.	PUNCT
admet-387	68	1	the	the	DET
admet-387	68	2	urate	urate	NOUN
admet-387	68	3	transport	transport	NOUN
admet-387	68	4	activity	activity	NOUN
admet-387	68	5	of	of	ADP
admet-387	68	6	urat1	urat1	NOUN
admet-387	68	7	depends	depend	VERB
admet-387	68	8	on	on	ADP
admet-387	68	9	a	a	DET
admet-387	68	10	system	system	NOUN
admet-387	68	11	of	of	ADP
admet-387	68	12	other	other	ADJ
admet-387	68	13	transporters	transporter	NOUN
admet-387	68	14	(	(	PUNCT
admet-387	68	15	yellow	yellow	ADJ
admet-387	68	16	in	in	ADP
admet-387	68	17	figure	figure	NOUN
admet-387	68	18	3	3	NUM
admet-387	68	19	)	)	PUNCT
admet-387	68	20	.	.	PUNCT
admet-387	69	1	the	the	DET
admet-387	69	2	primary	primary	ADJ
admet-387	69	3	active	active	ADJ
admet-387	69	4	transporter	transporter	NOUN
admet-387	69	5	na+/k+	na+/k+	PROPN
admet-387	69	6	atpase	atpase	PROPN
admet-387	69	7	provides	provide	VERB
admet-387	69	8	an	an	DET
admet-387	69	9	inward	inward	ADJ
admet-387	69	10	sodium	sodium	NOUN
admet-387	69	11	ion	ion	NOUN
admet-387	69	12	gradient	gradient	NOUN
admet-387	69	13	(	(	PUNCT
admet-387	69	14	higher	high	ADJ
admet-387	69	15	concentration	concentration	NOUN
admet-387	69	16	of	of	ADP
admet-387	69	17	extracellular	extracellular	ADJ
admet-387	69	18	sodium	sodium	NOUN
admet-387	69	19	ions	ion	NOUN
admet-387	69	20	)	)	PUNCT
admet-387	69	21	.	.	PUNCT
admet-387	70	1	the	the	DET
admet-387	70	2	secondary	secondary	ADJ
admet-387	70	3	active	active	ADJ
admet-387	70	4	transporters	transporter	NOUN
admet-387	70	5	,	,	PUNCT
admet-387	70	6	the	the	DET
admet-387	70	7	sodium	sodium	NOUN
admet-387	70	8	monocarboxylate	monocarboxylate	ADJ
admet-387	70	9	cotransporters	cotransporter	NOUN
admet-387	70	10	smct1	smct1	NOUN
admet-387	70	11	/	/	SYM
admet-387	70	12	slc5a8	slc5a8	NOUN
admet-387	70	13	and	and	CCONJ
admet-387	70	14	smct2	smct2	NOUN
admet-387	70	15	/	/	SYM
admet-387	70	16	slc5a12	slc5a12	ADV
admet-387	70	17	,	,	PUNCT
admet-387	70	18	use	use	VERB
admet-387	70	19	the	the	DET
admet-387	70	20	sodium	sodium	NOUN
admet-387	70	21	ion	ion	NOUN
admet-387	70	22	gradient	gradient	NOUN
admet-387	70	23	for	for	ADP
admet-387	70	24	the	the	DET
admet-387	70	25	inward	inward	ADJ
admet-387	70	26	cotransport	cotransport	NOUN
admet-387	70	27	of	of	ADP
admet-387	70	28	lactate	lactate	NOUN
admet-387	70	29	and	and	CCONJ
admet-387	70	30	other	other	ADJ
admet-387	70	31	monocarboxylates	monocarboxylate	NOUN
admet-387	70	32	.	.	PUNCT
admet-387	71	1	finally	finally	ADV
admet-387	71	2	,	,	PUNCT
admet-387	71	3	urat1	urat1	PROPN
admet-387	71	4	is	be	AUX
admet-387	71	5	the	the	DET
admet-387	71	6	tertiary	tertiary	ADJ
admet-387	71	7	active	active	ADJ
admet-387	71	8	transporter	transporter	NOUN
admet-387	71	9	in	in	ADP
admet-387	71	10	this	this	DET
admet-387	71	11	system	system	NOUN
admet-387	71	12	,	,	PUNCT
admet-387	71	13	requiring	require	VERB
admet-387	71	14	the	the	DET
admet-387	71	15	counterion	counterion	NOUN
admet-387	71	16	lactate	lactate	NOUN
admet-387	71	17	/	/	SYM
admet-387	71	18	monocarboxylate	monocarboxylate	PROPN
admet-387	71	19	gradient	gradient	NOUN
admet-387	71	20	generated	generate	VERB
admet-387	71	21	by	by	ADP
admet-387	71	22	smct1/2	smct1/2	ADJ
admet-387	71	23	for	for	ADP
admet-387	71	24	the	the	DET
admet-387	71	25	inward	inward	ADJ
admet-387	71	26	transport	transport	NOUN
admet-387	71	27	of	of	ADP
admet-387	71	28	urate	urate	NOUN
admet-387	71	29	.	.	PUNCT
admet-387	72	1	furthermore	furthermore	ADV
admet-387	72	2	,	,	PUNCT
admet-387	72	3	we	we	PRON
admet-387	72	4	suggest	suggest	VERB
admet-387	72	5	that	that	SCONJ
admet-387	72	6	the	the	DET
admet-387	72	7	sodium	sodium	NOUN
admet-387	72	8	/	/	SYM
admet-387	72	9	proton	proton	NOUN
admet-387	72	10	exchanger	exchanger	NOUN
admet-387	72	11	nhe3	nhe3	PROPN
admet-387	72	12	/	/	SYM
admet-387	72	13	slc9a3	slc9a3	PROPN
admet-387	72	14	,	,	PUNCT
admet-387	72	15	which	which	PRON
admet-387	72	16	imports	import	VERB
admet-387	72	17	sodium	sodium	NOUN
admet-387	72	18	ions	ion	NOUN
admet-387	72	19	and	and	CCONJ
admet-387	72	20	exports	export	NOUN
admet-387	72	21	protons	proton	NOUN
admet-387	72	22	,	,	PUNCT
admet-387	72	23	may	may	AUX
admet-387	72	24	also	also	ADV
admet-387	72	25	be	be	AUX
admet-387	72	26	important	important	ADJ
admet-387	72	27	for	for	ADP
admet-387	72	28	urat1	urat1	NOUN
admet-387	72	29	activity	activity	NOUN
admet-387	72	30	.	.	PUNCT
admet-387	73	1	this	this	DET
admet-387	73	2	system	system	NOUN
admet-387	73	3	of	of	ADP
admet-387	73	4	transporters	transporter	NOUN
admet-387	73	5	that	that	PRON
admet-387	73	6	is	be	AUX
admet-387	73	7	indirectly	indirectly	ADV
admet-387	73	8	involved	involve	VERB
admet-387	73	9	in	in	ADP
admet-387	73	10	import	import	NOUN
admet-387	73	11	of	of	ADP
admet-387	73	12	urate	urate	NOUN
admet-387	73	13	from	from	ADP
admet-387	73	14	the	the	DET
admet-387	73	15	lumen	luman	NOUN
admet-387	73	16	of	of	ADP
admet-387	73	17	the	the	DET
admet-387	73	18	proximal	proximal	ADJ
admet-387	73	19	tubule	tubule	NOUN
admet-387	73	20	are	be	AUX
admet-387	73	21	admet	admet	PROPN
admet-387	73	22	&	&	CCONJ
admet-387	73	23	dmpk	dmpk	PROPN
admet-387	73	24	5(2	5(2	NUM
admet-387	73	25	)	)	PUNCT
admet-387	73	26	(	(	PUNCT
admet-387	73	27	2017	2017	NUM
admet-387	73	28	)	)	PUNCT
admet-387	73	29	59	59	NUM
admet-387	73	30	-	-	SYM
admet-387	73	31	74	74	NUM
admet-387	73	32	uric	uric	ADJ
admet-387	73	33	acid	acid	NOUN
admet-387	73	34	transporter	transporter	NOUN
admet-387	73	35	inhibitors	inhibitor	NOUN
admet-387	73	36	for	for	ADP
admet-387	73	37	gout	gout	NOUN
admet-387	73	38	doi	doi	NOUN
admet-387	73	39	:	:	PUNCT
admet-387	73	40	10.5599	10.5599	NUM
admet-387	73	41	/	/	SYM
admet-387	73	42	admet.5.1.387	admet.5.1.387	PRON
admet-387	73	43	63	63	NUM
admet-387	73	44	sensitive	sensitive	ADJ
admet-387	73	45	to	to	ADP
admet-387	73	46	certain	certain	ADJ
admet-387	73	47	drugs	drug	NOUN
admet-387	73	48	that	that	PRON
admet-387	73	49	elevate	elevate	VERB
admet-387	73	50	sua	sua	NOUN
admet-387	73	51	levels	level	NOUN
admet-387	73	52	by	by	ADP
admet-387	73	53	increasing	increase	VERB
admet-387	73	54	the	the	DET
admet-387	73	55	urate	urate	NOUN
admet-387	73	56	transport	transport	NOUN
admet-387	73	57	activity	activity	NOUN
admet-387	73	58	of	of	ADP
admet-387	73	59	urat1	urat1	PROPN
admet-387	73	60	.	.	PUNCT
admet-387	74	1	for	for	ADP
admet-387	74	2	example	example	NOUN
admet-387	74	3	,	,	PUNCT
admet-387	74	4	diuretics	diuretic	NOUN
admet-387	74	5	reduce	reduce	VERB
admet-387	74	6	the	the	DET
admet-387	74	7	urinary	urinary	ADJ
admet-387	74	8	excretion	excretion	NOUN
admet-387	74	9	of	of	ADP
admet-387	74	10	urate	urate	NOUN
admet-387	74	11	and	and	CCONJ
admet-387	74	12	elevate	elevate	VERB
admet-387	74	13	sua	sua	PROPN
admet-387	74	14	levels	level	NOUN
admet-387	74	15	,	,	PUNCT
admet-387	74	16	possibly	possibly	ADV
admet-387	74	17	through	through	ADP
admet-387	74	18	enhanced	enhanced	ADJ
admet-387	74	19	sodium	sodium	NOUN
admet-387	74	20	reabsorption	reabsorption	NOUN
admet-387	74	21	in	in	ADP
admet-387	74	22	the	the	DET
admet-387	74	23	proximal	proximal	ADJ
admet-387	74	24	tubule	tubule	NOUN
admet-387	74	25	.	.	PUNCT
admet-387	75	1	this	this	DET
admet-387	75	2	effect	effect	NOUN
admet-387	75	3	would	would	AUX
admet-387	75	4	elevate	elevate	VERB
admet-387	75	5	the	the	DET
admet-387	75	6	intracellular	intracellular	ADJ
admet-387	75	7	levels	level	NOUN
admet-387	75	8	of	of	ADP
admet-387	75	9	lactate	lactate	NOUN
admet-387	75	10	within	within	ADP
admet-387	75	11	the	the	DET
admet-387	75	12	renal	renal	ADJ
admet-387	75	13	proximal	proximal	ADJ
admet-387	75	14	epithelial	epithelial	ADJ
admet-387	75	15	cells	cell	NOUN
admet-387	75	16	(	(	PUNCT
admet-387	75	17	through	through	ADP
admet-387	75	18	slc5a8/12	slc5a8/12	NOUN
admet-387	75	19	)	)	PUNCT
admet-387	75	20	and	and	CCONJ
admet-387	75	21	also	also	ADV
admet-387	75	22	lower	lower	VERB
admet-387	75	23	the	the	DET
admet-387	75	24	extracellular	extracellular	ADJ
admet-387	75	25	ph	ph	NOUN
admet-387	75	26	(	(	PUNCT
admet-387	75	27	through	through	ADP
admet-387	75	28	nhe3	nhe3	PROPN
admet-387	75	29	)	)	PUNCT
admet-387	75	30	,	,	PUNCT
admet-387	75	31	enhancing	enhance	VERB
admet-387	75	32	the	the	DET
admet-387	75	33	reabsorption	reabsorption	NOUN
admet-387	75	34	of	of	ADP
admet-387	75	35	urate	urate	NOUN
admet-387	75	36	by	by	ADP
admet-387	75	37	urat1	urat1	PROPN
admet-387	75	38	.	.	PUNCT
admet-387	75	39	figure	figure	NOUN
admet-387	75	40	3	3	NUM
admet-387	75	41	.	.	PUNCT
admet-387	76	1	the	the	DET
admet-387	76	2	scaffolding	scaffold	VERB
admet-387	76	3	protein	protein	NOUN
admet-387	76	4	nherf3	nherf3	NOUN
admet-387	76	5	/	/	SYM
admet-387	76	6	pdzk1	pdzk1	NOUN
admet-387	76	7	clusters	cluster	NOUN
admet-387	76	8	apical	apical	ADJ
admet-387	76	9	membrane	membrane	NOUN
admet-387	76	10	urate	urate	NOUN
admet-387	76	11	transporters	transporter	NOUN
admet-387	76	12	into	into	ADP
admet-387	76	13	a	a	DET
admet-387	76	14	“	"	PUNCT
admet-387	76	15	urate	urate	NOUN
admet-387	76	16	transportasome	transportasome	NOUN
admet-387	76	17	”	"	PUNCT
admet-387	76	18	for	for	ADP
admet-387	76	19	more	more	ADV
admet-387	76	20	efficient	efficient	ADJ
admet-387	76	21	urate	urate	NOUN
admet-387	76	22	handling	handling	NOUN
admet-387	76	23	in	in	ADP
admet-387	76	24	the	the	DET
admet-387	76	25	kidney	kidney	NOUN
admet-387	76	26	.	.	PUNCT
admet-387	77	1	transporters	transporter	NOUN
admet-387	77	2	indicated	indicate	VERB
admet-387	77	3	in	in	ADP
admet-387	77	4	yellow	yellow	ADJ
admet-387	77	5	do	do	AUX
admet-387	77	6	not	not	PART
admet-387	77	7	transport	transport	VERB
admet-387	77	8	urate	urate	NOUN
admet-387	77	9	,	,	PUNCT
admet-387	77	10	but	but	CCONJ
admet-387	77	11	are	be	AUX
admet-387	77	12	important	important	ADJ
admet-387	77	13	for	for	ADP
admet-387	77	14	the	the	DET
admet-387	77	15	transport	transport	NOUN
admet-387	77	16	of	of	ADP
admet-387	77	17	urate	urate	NOUN
admet-387	77	18	by	by	ADP
admet-387	77	19	urat1	urat1	PROPN
admet-387	77	20	(	(	PUNCT
admet-387	77	21	see	see	VERB
admet-387	77	22	text	text	NOUN
admet-387	77	23	for	for	ADP
admet-387	77	24	further	further	ADJ
admet-387	77	25	details	detail	NOUN
admet-387	77	26	)	)	PUNCT
admet-387	77	27	.	.	PUNCT
admet-387	78	1	for	for	ADP
admet-387	78	2	simplicity	simplicity	NOUN
admet-387	78	3	,	,	PUNCT
admet-387	78	4	certain	certain	ADJ
admet-387	78	5	transporters	transporter	NOUN
admet-387	78	6	are	be	AUX
admet-387	78	7	grouped	group	VERB
admet-387	78	8	together	together	ADV
admet-387	78	9	(	(	PUNCT
admet-387	78	10	e.g.	e.g.	ADV
admet-387	78	11	npt1	npt1	NOUN
admet-387	78	12	and	and	CCONJ
admet-387	78	13	npt4	npt4	NOUN
admet-387	78	14	)	)	PUNCT
admet-387	78	15	.	.	PUNCT
admet-387	79	1	glut9	glut9	NOUN
admet-387	80	1	the	the	DET
admet-387	80	2	slc	slc	PROPN
admet-387	80	3	family	family	PROPN
admet-387	80	4	2a	2a	NUM
admet-387	80	5	,	,	PUNCT
admet-387	80	6	facilitated	facilitate	VERB
admet-387	80	7	glucose	glucose	NOUN
admet-387	80	8	transporter	transporter	NOUN
admet-387	80	9	member	member	NOUN
admet-387	80	10	9	9	NUM
admet-387	80	11	(	(	PUNCT
admet-387	80	12	glut9	glut9	NOUN
admet-387	80	13	/	/	SYM
admet-387	80	14	slc2a9	slc2a9	NOUN
admet-387	80	15	)	)	PUNCT
admet-387	80	16	,	,	PUNCT
admet-387	80	17	like	like	ADP
admet-387	80	18	urat1	urat1	PROPN
admet-387	80	19	,	,	PUNCT
admet-387	80	20	is	be	AUX
admet-387	80	21	also	also	ADV
admet-387	80	22	essential	essential	ADJ
admet-387	80	23	for	for	ADP
admet-387	80	24	the	the	DET
admet-387	80	25	efficient	efficient	ADJ
admet-387	80	26	reabsorption	reabsorption	NOUN
admet-387	80	27	of	of	ADP
admet-387	80	28	urate	urate	NOUN
admet-387	80	29	from	from	ADP
admet-387	80	30	the	the	DET
admet-387	80	31	renal	renal	ADJ
admet-387	80	32	proximal	proximal	ADJ
admet-387	80	33	tubule	tubule	NOUN
admet-387	80	34	(	(	PUNCT
admet-387	80	35	figure	figure	NOUN
admet-387	80	36	1a	1a	NOUN
admet-387	80	37	)	)	PUNCT
admet-387	80	38	.	.	PUNCT
admet-387	81	1	individuals	individual	NOUN
admet-387	81	2	carrying	carry	VERB
admet-387	81	3	inactivating	inactivate	VERB
admet-387	81	4	mutations	mutation	NOUN
admet-387	81	5	in	in	ADP
admet-387	81	6	glut9	glut9	NOUN
admet-387	81	7	have	have	VERB
admet-387	81	8	renal	renal	ADJ
admet-387	81	9	hypouricemia	hypouricemia	PROPN
admet-387	81	10	and	and	CCONJ
admet-387	81	11	very	very	ADV
admet-387	81	12	high	high	ADJ
admet-387	81	13	levels	level	NOUN
admet-387	81	14	of	of	ADP
admet-387	81	15	urinary	urinary	ADJ
admet-387	81	16	uric	uric	ADJ
admet-387	81	17	acid	acid	NOUN
admet-387	81	18	excretion	excretion	NOUN
admet-387	81	19	.	.	PUNCT
admet-387	82	1	in	in	ADP
admet-387	82	2	some	some	DET
admet-387	82	3	individuals	individual	NOUN
admet-387	82	4	with	with	ADP
admet-387	82	5	inactivating	inactivating	ADJ
admet-387	82	6	glut9	glut9	NOUN
admet-387	82	7	mutations	mutation	NOUN
admet-387	82	8	,	,	PUNCT
admet-387	82	9	the	the	DET
admet-387	82	10	fractional	fractional	ADJ
admet-387	82	11	excretion	excretion	NOUN
admet-387	82	12	of	of	ADP
admet-387	82	13	uric	uric	ADJ
admet-387	82	14	acid	acid	NOUN
admet-387	82	15	exceeds	exceed	VERB
admet-387	82	16	100	100	NUM
admet-387	82	17	%	%	NOUN
admet-387	82	18	(	(	PUNCT
admet-387	82	19	meaning	mean	VERB
admet-387	82	20	that	that	SCONJ
admet-387	82	21	the	the	DET
admet-387	82	22	amount	amount	NOUN
admet-387	82	23	of	of	ADP
admet-387	82	24	renally	renally	ADV
admet-387	82	25	excreted	excrete	VERB
admet-387	82	26	uric	uric	ADJ
admet-387	82	27	acid	acid	NOUN
admet-387	82	28	exceeds	exceed	VERB
admet-387	82	29	the	the	DET
admet-387	82	30	amount	amount	NOUN
admet-387	82	31	of	of	ADP
admet-387	82	32	glomerularfiltered	glomerularfiltere	VERB
admet-387	82	33	uric	uric	ADJ
admet-387	82	34	acid	acid	NOUN
admet-387	82	35	)	)	PUNCT
admet-387	82	36	,	,	PUNCT
admet-387	82	37	providing	provide	VERB
admet-387	82	38	evidence	evidence	NOUN
admet-387	82	39	that	that	SCONJ
admet-387	82	40	uric	uric	ADJ
admet-387	82	41	acid	acid	NOUN
admet-387	82	42	is	be	AUX
admet-387	82	43	actively	actively	ADV
admet-387	82	44	secreted	secrete	VERB
admet-387	82	45	in	in	ADP
admet-387	82	46	the	the	DET
admet-387	82	47	kidneys	kidney	NOUN
admet-387	82	48	(	(	PUNCT
admet-387	82	49	red	red	ADJ
admet-387	82	50	arrow	arrow	NOUN
admet-387	82	51	in	in	ADP
admet-387	82	52	figure	figure	NOUN
admet-387	82	53	1	1	NUM
admet-387	82	54	)	)	PUNCT
admet-387	82	55	.	.	PUNCT
admet-387	83	1	the	the	DET
admet-387	83	2	long	long	ADJ
admet-387	83	3	isoform	isoform	NOUN
admet-387	83	4	of	of	ADP
admet-387	83	5	glut9	glut9	NOUN
admet-387	83	6	(	(	PUNCT
admet-387	83	7	glut9a	glut9a	NOUN
admet-387	83	8	or	or	CCONJ
admet-387	83	9	-l	-l	NUM
admet-387	83	10	)	)	PUNCT
admet-387	83	11	is	be	AUX
admet-387	83	12	localized	localize	VERB
admet-387	83	13	to	to	ADP
admet-387	83	14	the	the	DET
admet-387	83	15	basolateral	basolateral	ADJ
admet-387	83	16	membrane	membrane	NOUN
admet-387	83	17	of	of	ADP
admet-387	83	18	rptecs	rptec	NOUN
admet-387	83	19	,	,	PUNCT
admet-387	83	20	and	and	CCONJ
admet-387	83	21	transports	transport	VERB
admet-387	83	22	uric	uric	ADJ
admet-387	83	23	acid	acid	NOUN
admet-387	83	24	along	along	ADP
admet-387	83	25	its	its	PRON
admet-387	83	26	concentration	concentration	NOUN
admet-387	83	27	gradient	gradient	NOUN
admet-387	83	28	from	from	ADP
admet-387	83	29	inside	inside	ADP
admet-387	83	30	the	the	DET
admet-387	83	31	cells	cell	NOUN
admet-387	83	32	to	to	ADP
admet-387	83	33	the	the	DET
admet-387	83	34	blood	blood	NOUN
admet-387	83	35	,	,	PUNCT
admet-387	83	36	completing	complete	VERB
admet-387	83	37	the	the	DET
admet-387	83	38	process	process	NOUN
admet-387	83	39	of	of	ADP
admet-387	83	40	uric	uric	ADJ
admet-387	83	41	acid	acid	NOUN
admet-387	83	42	reabsorption	reabsorption	NOUN
admet-387	83	43	that	that	PRON
admet-387	83	44	is	be	AUX
admet-387	83	45	initiated	initiate	VERB
admet-387	83	46	by	by	ADP
admet-387	83	47	urat1	urat1	NOUN
admet-387	83	48	(	(	PUNCT
admet-387	83	49	figure	figure	NOUN
admet-387	83	50	1a	1a	NOUN
admet-387	83	51	)	)	PUNCT
admet-387	83	52	.	.	PUNCT
admet-387	84	1	unlike	unlike	ADP
admet-387	84	2	urat1	urat1	PROPN
admet-387	84	3	,	,	PUNCT
admet-387	84	4	there	there	PRON
admet-387	84	5	are	be	VERB
admet-387	84	6	no	no	DET
admet-387	84	7	medications	medication	NOUN
admet-387	84	8	that	that	PRON
admet-387	84	9	target	target	VERB
admet-387	84	10	glut9	glut9	NOUN
admet-387	84	11	.	.	PUNCT
admet-387	85	1	similar	similar	ADJ
admet-387	85	2	to	to	ADP
admet-387	85	3	other	other	ADJ
admet-387	85	4	members	member	NOUN
admet-387	85	5	of	of	ADP
admet-387	85	6	the	the	DET
admet-387	85	7	slc2	slc2	PROPN
admet-387	85	8	family	family	NOUN
admet-387	85	9	,	,	PUNCT
admet-387	85	10	glut9	glut9	NOUN
admet-387	85	11	has	have	AUX
admet-387	85	12	been	be	AUX
admet-387	85	13	shown	show	VERB
admet-387	85	14	to	to	PART
admet-387	85	15	transport	transport	VERB
admet-387	85	16	glucose	glucose	NOUN
admet-387	85	17	and	and	CCONJ
admet-387	85	18	other	other	ADJ
admet-387	85	19	sugars	sugar	NOUN
admet-387	85	20	,	,	PUNCT
admet-387	85	21	although	although	SCONJ
admet-387	85	22	this	this	PRON
admet-387	85	23	has	have	AUX
admet-387	85	24	recently	recently	ADV
admet-387	85	25	been	be	AUX
admet-387	85	26	questioned	question	VERB
admet-387	85	27	[	[	X
admet-387	85	28	21	21	NUM
admet-387	85	29	]	]	PUNCT
admet-387	85	30	.	.	PUNCT
admet-387	86	1	however	however	ADV
admet-387	86	2	,	,	PUNCT
admet-387	86	3	sugars	sugar	NOUN
admet-387	86	4	may	may	AUX
admet-387	86	5	influence	influence	VERB
admet-387	86	6	the	the	DET
admet-387	86	7	transport	transport	NOUN
admet-387	86	8	of	of	ADP
admet-387	86	9	urate	urate	NOUN
admet-387	86	10	by	by	ADP
admet-387	86	11	glut9	glut9	NOUN
admet-387	87	1	[	[	X
admet-387	87	2	22	22	NUM
admet-387	87	3	]	]	PUNCT
admet-387	87	4	,	,	PUNCT
admet-387	87	5	suggesting	suggest	VERB
admet-387	87	6	that	that	SCONJ
admet-387	87	7	dietary	dietary	ADJ
admet-387	87	8	sugars	sugar	NOUN
admet-387	87	9	can	can	AUX
admet-387	87	10	influence	influence	VERB
admet-387	87	11	sua	sua	NOUN
admet-387	87	12	levels	level	NOUN
admet-387	87	13	through	through	ADP
admet-387	87	14	glut9	glut9	NOUN
admet-387	87	15	.	.	PUNCT
admet-387	88	1	a	a	DET
admet-387	88	2	short	short	ADJ
admet-387	88	3	isoform	isoform	NOUN
admet-387	88	4	of	of	ADP
admet-387	88	5	glut9	glut9	NOUN
admet-387	88	6	(	(	PUNCT
admet-387	88	7	glut9b	glut9b	ADJ
admet-387	88	8	or	or	CCONJ
admet-387	88	9	–	–	PUNCT
admet-387	88	10	s	s	X
admet-387	88	11	)	)	PUNCT
admet-387	88	12	differs	differ	VERB
admet-387	88	13	at	at	ADP
admet-387	88	14	the	the	DET
admet-387	88	15	amino	amino	ADJ
admet-387	88	16	terminus	terminus	NOUN
admet-387	88	17	from	from	ADP
admet-387	88	18	the	the	DET
admet-387	88	19	longer	long	ADJ
admet-387	88	20	isoform	isoform	NOUN
admet-387	88	21	due	due	ADP
admet-387	88	22	to	to	ADP
admet-387	88	23	alternative	alternative	ADJ
admet-387	88	24	splicing	splicing	NOUN
admet-387	88	25	.	.	PUNCT
admet-387	89	1	an	an	DET
admet-387	89	2	antibody	antibody	NOUN
admet-387	89	3	raised	raise	VERB
admet-387	89	4	against	against	ADP
admet-387	89	5	the	the	DET
admet-387	89	6	unique	unique	ADJ
admet-387	89	7	21	21	NUM
admet-387	89	8	amino	amino	NOUN
admet-387	89	9	terminal	terminal	NOUN
admet-387	89	10	amino	amino	NOUN
admet-387	89	11	acids	acid	NOUN
admet-387	89	12	of	of	ADP
admet-387	89	13	glut9b	glut9b	PROPN
admet-387	89	14	detected	detect	VERB
admet-387	89	15	this	this	DET
admet-387	89	16	variant	variant	NOUN
admet-387	89	17	on	on	ADP
admet-387	89	18	membranes	membrane	NOUN
admet-387	89	19	of	of	ADP
admet-387	89	20	epithelial	epithelial	ADJ
admet-387	89	21	cells	cell	NOUN
admet-387	89	22	in	in	ADP
admet-387	89	23	the	the	DET
admet-387	89	24	collecting	collect	VERB
admet-387	89	25	duct	duct	NOUN
admet-387	89	26	[	[	X
admet-387	89	27	23	23	NUM
admet-387	89	28	]	]	PUNCT
admet-387	89	29	,	,	PUNCT
admet-387	89	30	suggesting	suggest	VERB
admet-387	89	31	the	the	DET
admet-387	89	32	possibility	possibility	NOUN
admet-387	89	33	that	that	SCONJ
admet-387	89	34	this	this	DET
admet-387	89	35	distal	distal	ADJ
admet-387	89	36	segment	segment	NOUN
admet-387	89	37	of	of	ADP
admet-387	89	38	the	the	DET
admet-387	89	39	nephron	nephron	NOUN
admet-387	89	40	handles	handle	VERB
admet-387	89	41	urate	urate	NOUN
admet-387	89	42	.	.	PUNCT
admet-387	90	1	interestingly	interestingly	ADV
admet-387	90	2	,	,	PUNCT
admet-387	90	3	this	this	DET
admet-387	90	4	antibody	antibody	NOUN
admet-387	90	5	did	do	AUX
admet-387	90	6	not	not	PART
admet-387	90	7	detect	detect	VERB
admet-387	90	8	glut9b	glut9b	PROPN
admet-387	90	9	on	on	ADP
admet-387	90	10	the	the	DET
admet-387	90	11	proximal	proximal	ADJ
admet-387	90	12	tubule	tubule	NOUN
admet-387	90	13	.	.	PUNCT
admet-387	91	1	tan	tan	PROPN
admet-387	91	2	and	and	CCONJ
admet-387	91	3	miner	miner	PROPN
admet-387	91	4	admet	admet	PROPN
admet-387	91	5	&	&	CCONJ
admet-387	91	6	dmpk	dmpk	PROPN
admet-387	91	7	5(2	5(2	NUM
admet-387	91	8	)	)	PUNCT
admet-387	91	9	(	(	PUNCT
admet-387	91	10	2017	2017	NUM
admet-387	91	11	)	)	PUNCT
admet-387	91	12	59	59	NUM
admet-387	91	13	-	-	SYM
admet-387	91	14	74	74	NUM
admet-387	91	15	64	64	NUM
admet-387	91	16	oat4	oat4	NOUN
admet-387	91	17	oat4	oat4	NOUN
admet-387	91	18	/	/	PUNCT
admet-387	91	19	slc22a11	slc22a11	PROPN
admet-387	91	20	is	be	AUX
admet-387	91	21	expressed	express	VERB
admet-387	91	22	on	on	ADP
admet-387	91	23	the	the	DET
admet-387	91	24	apical	apical	ADJ
admet-387	91	25	membrane	membrane	NOUN
admet-387	91	26	of	of	ADP
admet-387	91	27	rptecs	rptec	NOUN
admet-387	91	28	(	(	PUNCT
admet-387	91	29	figure	figure	NOUN
admet-387	91	30	1a	1a	NOUN
admet-387	91	31	)	)	PUNCT
admet-387	91	32	,	,	PUNCT
admet-387	91	33	has	have	VERB
admet-387	91	34	a	a	DET
admet-387	91	35	51	51	NUM
admet-387	91	36	%	%	NOUN
admet-387	91	37	amino	amino	NOUN
admet-387	91	38	acid	acid	NOUN
admet-387	91	39	identity	identity	NOUN
admet-387	91	40	to	to	ADP
admet-387	91	41	urat1	urat1	NOUN
admet-387	91	42	,	,	PUNCT
admet-387	91	43	and	and	CCONJ
admet-387	91	44	has	have	VERB
admet-387	91	45	a	a	DET
admet-387	91	46	strong	strong	ADJ
admet-387	91	47	genetic	genetic	ADJ
admet-387	91	48	association	association	NOUN
admet-387	91	49	with	with	ADP
admet-387	91	50	sua	sua	PROPN
admet-387	91	51	levels	level	NOUN
admet-387	91	52	.	.	PUNCT
admet-387	92	1	however	however	ADV
admet-387	92	2	,	,	PUNCT
admet-387	92	3	oat4	oat4	PROPN
admet-387	92	4	is	be	AUX
admet-387	92	5	a	a	DET
admet-387	92	6	weak	weak	ADJ
admet-387	92	7	transporter	transporter	NOUN
admet-387	92	8	of	of	ADP
admet-387	92	9	uric	uric	ADJ
admet-387	92	10	acid	acid	NOUN
admet-387	92	11	in	in	ADP
admet-387	92	12	vitro	vitro	NOUN
admet-387	92	13	,	,	PUNCT
admet-387	92	14	and	and	CCONJ
admet-387	92	15	its	its	PRON
admet-387	92	16	role	role	NOUN
admet-387	92	17	in	in	ADP
admet-387	92	18	vivo	vivo	NOUN
admet-387	92	19	in	in	ADP
admet-387	92	20	uric	uric	ADJ
admet-387	92	21	acid	acid	NOUN
admet-387	92	22	transport	transport	NOUN
admet-387	92	23	and	and	CCONJ
admet-387	92	24	homeostasis	homeostasis	NOUN
admet-387	92	25	is	be	AUX
admet-387	92	26	unclear	unclear	ADJ
admet-387	92	27	.	.	PUNCT
admet-387	93	1	inactivating	inactivate	VERB
admet-387	93	2	mutations	mutation	NOUN
admet-387	93	3	of	of	ADP
admet-387	93	4	oat4	oat4	NOUN
admet-387	93	5	have	have	AUX
admet-387	93	6	been	be	AUX
admet-387	93	7	reported	report	VERB
admet-387	93	8	[	[	X
admet-387	93	9	24	24	NUM
admet-387	93	10	]	]	PUNCT
admet-387	93	11	but	but	CCONJ
admet-387	93	12	the	the	DET
admet-387	93	13	sua	sua	PROPN
admet-387	93	14	levels	level	NOUN
admet-387	93	15	in	in	ADP
admet-387	93	16	the	the	DET
admet-387	93	17	individuals	individual	NOUN
admet-387	93	18	carrying	carry	VERB
admet-387	93	19	these	these	DET
admet-387	93	20	mutations	mutation	NOUN
admet-387	93	21	is	be	AUX
admet-387	93	22	unknown	unknown	ADJ
admet-387	93	23	.	.	PUNCT
admet-387	94	1	similar	similar	ADJ
admet-387	94	2	to	to	ADP
admet-387	94	3	urat1	urat1	PROPN
admet-387	94	4	,	,	PUNCT
admet-387	94	5	oat4	oat4	PROPN
admet-387	94	6	is	be	AUX
admet-387	94	7	an	an	DET
admet-387	94	8	organic	organic	ADJ
admet-387	94	9	anion	anion	NOUN
admet-387	94	10	exchanger	exchanger	NOUN
admet-387	94	11	,	,	PUNCT
admet-387	94	12	and	and	CCONJ
admet-387	94	13	diuretics	diuretic	NOUN
admet-387	94	14	such	such	ADJ
admet-387	94	15	as	as	ADP
admet-387	94	16	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-387	94	17	were	be	AUX
admet-387	94	18	shown	show	VERB
admet-387	94	19	to	to	PART
admet-387	94	20	enhance	enhance	VERB
admet-387	94	21	urate	urate	NOUN
admet-387	94	22	import	import	NOUN
admet-387	94	23	by	by	ADP
admet-387	94	24	oat4	oat4	PROPN
admet-387	94	25	(	(	PUNCT
admet-387	94	26	trans	trans	NOUN
admet-387	94	27	-	-	NOUN
admet-387	94	28	stimulation	stimulation	NOUN
admet-387	94	29	)	)	PUNCT
admet-387	94	30	,	,	PUNCT
admet-387	94	31	explaining	explain	VERB
admet-387	94	32	a	a	DET
admet-387	94	33	possible	possible	ADJ
admet-387	94	34	oat4	oat4	NOUN
admet-387	94	35	-	-	PUNCT
admet-387	94	36	dependent	dependent	ADJ
admet-387	94	37	mechanism	mechanism	NOUN
admet-387	94	38	for	for	ADP
admet-387	94	39	diuretic	diuretic	NOUN
admet-387	94	40	-	-	PUNCT
admet-387	94	41	induced	induce	VERB
admet-387	94	42	hyperuricemia	hyperuricemia	NOUN
admet-387	95	1	[	[	X
admet-387	95	2	25	25	NUM
admet-387	95	3	]	]	PUNCT
admet-387	95	4	.	.	PUNCT
admet-387	96	1	however	however	ADV
admet-387	96	2	,	,	PUNCT
admet-387	96	3	to	to	ADP
admet-387	96	4	our	our	PRON
admet-387	96	5	knowledge	knowledge	NOUN
admet-387	96	6	these	these	DET
admet-387	96	7	studies	study	NOUN
admet-387	96	8	have	have	AUX
admet-387	96	9	not	not	PART
admet-387	96	10	yet	yet	ADV
admet-387	96	11	been	be	AUX
admet-387	96	12	replicated	replicate	VERB
admet-387	96	13	,	,	PUNCT
admet-387	96	14	and	and	CCONJ
admet-387	96	15	mixed	mixed	ADJ
admet-387	96	16	findings	finding	NOUN
admet-387	96	17	have	have	AUX
admet-387	96	18	been	be	AUX
admet-387	96	19	reported	report	VERB
admet-387	96	20	on	on	ADP
admet-387	96	21	the	the	DET
admet-387	96	22	genetic	genetic	ADJ
admet-387	96	23	association	association	NOUN
admet-387	96	24	of	of	ADP
admet-387	96	25	oat4	oat4	PROPN
admet-387	96	26	with	with	ADP
admet-387	96	27	diuretic	diuretic	NOUN
admet-387	96	28	-	-	PUNCT
admet-387	96	29	associated	associate	VERB
admet-387	96	30	gout	gout	NOUN
admet-387	97	1	[	[	X
admet-387	97	2	26	26	NUM
admet-387	97	3	,	,	PUNCT
admet-387	97	4	27	27	NUM
admet-387	97	5	]	]	PUNCT
admet-387	97	6	.	.	PUNCT
admet-387	98	1	oat4	oat4	PROPN
admet-387	98	2	is	be	AUX
admet-387	98	3	not	not	PART
admet-387	98	4	expressed	express	VERB
admet-387	98	5	in	in	ADP
admet-387	98	6	mice	mouse	NOUN
admet-387	98	7	,	,	PUNCT
admet-387	98	8	and	and	CCONJ
admet-387	98	9	no	no	DET
admet-387	98	10	specific	specific	ADJ
admet-387	98	11	oat4	oat4	NOUN
admet-387	98	12	inhibitors	inhibitor	NOUN
admet-387	98	13	are	be	AUX
admet-387	98	14	known	know	VERB
admet-387	98	15	(	(	PUNCT
admet-387	98	16	lesinurad	lesinurad	PROPN
admet-387	98	17	and	and	CCONJ
admet-387	98	18	probenecid	probenecid	PROPN
admet-387	98	19	inhibit	inhibit	PROPN
admet-387	98	20	oat4	oat4	PROPN
admet-387	98	21	,	,	PUNCT
admet-387	98	22	but	but	CCONJ
admet-387	98	23	also	also	ADV
admet-387	98	24	other	other	ADJ
admet-387	98	25	transporters	transporter	NOUN
admet-387	98	26	)	)	PUNCT
admet-387	98	27	,	,	PUNCT
admet-387	98	28	hampering	hamper	VERB
admet-387	98	29	efforts	effort	NOUN
admet-387	98	30	to	to	PART
admet-387	98	31	study	study	VERB
admet-387	98	32	oat4	oat4	NOUN
admet-387	98	33	using	use	VERB
admet-387	98	34	genetic	genetic	ADJ
admet-387	98	35	or	or	CCONJ
admet-387	98	36	pharmacological	pharmacological	ADJ
admet-387	98	37	methods	method	NOUN
admet-387	98	38	.	.	PUNCT
admet-387	99	1	oat10	oat10	PROPN
admet-387	99	2	oat10	oat10	ADJ
admet-387	99	3	/	/	SYM
admet-387	99	4	slc22a13	slc22a13	NOUN
admet-387	99	5	was	be	AUX
admet-387	99	6	initially	initially	ADV
admet-387	99	7	characterized	characterize	VERB
admet-387	99	8	as	as	ADP
admet-387	99	9	a	a	DET
admet-387	99	10	urate	urate	NOUN
admet-387	99	11	transporter	transporter	NOUN
admet-387	99	12	that	that	PRON
admet-387	99	13	is	be	AUX
admet-387	99	14	expressed	express	VERB
admet-387	99	15	on	on	ADP
admet-387	99	16	apical	apical	ADJ
admet-387	99	17	membranes	membrane	NOUN
admet-387	99	18	of	of	ADP
admet-387	99	19	proximal	proximal	ADJ
admet-387	99	20	tubule	tubule	NOUN
admet-387	99	21	cells	cell	NOUN
admet-387	99	22	and	and	CCONJ
admet-387	99	23	trans	tran	NOUN
admet-387	99	24	-	-	VERB
admet-387	99	25	stimulated	stimulate	VERB
admet-387	99	26	by	by	ADP
admet-387	99	27	cyclosporine	cyclosporine	NOUN
admet-387	99	28	,	,	PUNCT
admet-387	99	29	explaining	explain	VERB
admet-387	99	30	a	a	DET
admet-387	99	31	mechanism	mechanism	NOUN
admet-387	99	32	for	for	ADP
admet-387	99	33	cyclosporine	cyclosporine	NOUN
admet-387	99	34	-	-	PUNCT
admet-387	99	35	induced	induce	VERB
admet-387	99	36	hyperuricemia	hyperuricemia	NOUN
admet-387	100	1	[	[	X
admet-387	100	2	28	28	NUM
admet-387	100	3	]	]	PUNCT
admet-387	100	4	.	.	PUNCT
admet-387	101	1	this	this	DET
admet-387	101	2	localization	localization	NOUN
admet-387	101	3	is	be	AUX
admet-387	101	4	supported	support	VERB
admet-387	101	5	by	by	ADP
admet-387	101	6	a	a	DET
admet-387	101	7	subsequent	subsequent	ADJ
admet-387	101	8	report	report	NOUN
admet-387	101	9	using	use	VERB
admet-387	101	10	different	different	ADJ
admet-387	101	11	antibodies	antibody	NOUN
admet-387	101	12	[	[	X
admet-387	101	13	29	29	NUM
admet-387	101	14	]	]	PUNCT
admet-387	101	15	,	,	PUNCT
admet-387	101	16	but	but	CCONJ
admet-387	101	17	is	be	AUX
admet-387	101	18	inconsistent	inconsistent	ADJ
admet-387	101	19	with	with	ADP
admet-387	101	20	a	a	DET
admet-387	101	21	third	third	ADJ
admet-387	101	22	study	study	NOUN
admet-387	101	23	which	which	PRON
admet-387	101	24	shows	show	VERB
admet-387	101	25	localization	localization	NOUN
admet-387	101	26	on	on	ADP
admet-387	101	27	basolateral	basolateral	ADJ
admet-387	101	28	membranes	membrane	NOUN
admet-387	101	29	of	of	ADP
admet-387	101	30	the	the	DET
admet-387	101	31	collecting	collect	VERB
admet-387	101	32	duct	duct	NOUN
admet-387	101	33	[	[	X
admet-387	101	34	30	30	NUM
admet-387	101	35	]	]	PUNCT
admet-387	101	36	.	.	PUNCT
admet-387	102	1	oat10	oat10	ADJ
admet-387	102	2	,	,	PUNCT
admet-387	102	3	however	however	ADV
admet-387	102	4	,	,	PUNCT
admet-387	102	5	has	have	VERB
admet-387	102	6	a	a	DET
admet-387	102	7	consensus	consensus	NOUN
admet-387	102	8	c	c	NOUN
admet-387	102	9	-	-	PUNCT
admet-387	102	10	terminal	terminal	ADJ
admet-387	102	11	pdz	pdz	NOUN
admet-387	102	12	recognition	recognition	NOUN
admet-387	102	13	motif	motif	NOUN
admet-387	102	14	(	(	PUNCT
admet-387	102	15	table	table	NOUN
admet-387	102	16	1	1	NUM
admet-387	102	17	)	)	PUNCT
admet-387	102	18	for	for	ADP
admet-387	102	19	localization	localization	NOUN
admet-387	102	20	to	to	ADP
admet-387	102	21	apical	apical	ADJ
admet-387	102	22	membranes	membrane	NOUN
admet-387	102	23	of	of	ADP
admet-387	102	24	proximal	proximal	ADJ
admet-387	102	25	tubule	tubule	NOUN
admet-387	102	26	cells	cell	NOUN
admet-387	102	27	.	.	PUNCT
admet-387	103	1	no	no	DET
admet-387	103	2	genetic	genetic	ADJ
admet-387	103	3	association	association	NOUN
admet-387	103	4	of	of	ADP
admet-387	103	5	oat10	oat10	PROPN
admet-387	103	6	with	with	ADP
admet-387	103	7	sua	sua	PROPN
admet-387	103	8	levels	level	NOUN
admet-387	103	9	has	have	AUX
admet-387	103	10	been	be	AUX
admet-387	103	11	found	find	VERB
admet-387	103	12	,	,	PUNCT
admet-387	103	13	and	and	CCONJ
admet-387	103	14	the	the	DET
admet-387	103	15	role	role	NOUN
admet-387	103	16	of	of	ADP
admet-387	103	17	oat10	oat10	ADJ
admet-387	103	18	in	in	ADP
admet-387	103	19	urate	urate	NOUN
admet-387	103	20	transport	transport	NOUN
admet-387	103	21	and	and	CCONJ
admet-387	103	22	homeostasis	homeostasis	NOUN
admet-387	103	23	needs	need	NOUN
admet-387	103	24	to	to	PART
admet-387	103	25	be	be	AUX
admet-387	103	26	further	far	ADV
admet-387	103	27	characterized	characterize	VERB
admet-387	103	28	.	.	PUNCT
admet-387	104	1	table	table	NOUN
admet-387	104	2	1	1	NUM
admet-387	104	3	.	.	X
admet-387	104	4	carboxyl	carboxyl	NOUN
admet-387	104	5	(	(	PUNCT
admet-387	104	6	c-	c-	X
admet-387	104	7	)	)	PUNCT
admet-387	104	8	terminal	terminal	ADJ
admet-387	104	9	sequences	sequence	NOUN
admet-387	104	10	of	of	ADP
admet-387	104	11	transporters	transporter	NOUN
admet-387	104	12	known	know	VERB
admet-387	104	13	or	or	CCONJ
admet-387	104	14	presumed	presume	VERB
admet-387	104	15	to	to	PART
admet-387	104	16	interact	interact	VERB
admet-387	104	17	with	with	ADP
admet-387	104	18	pdzk1	pdzk1	PROPN
admet-387	104	19	.	.	PUNCT
admet-387	105	1	location	location	NOUN
admet-387	105	2	transporter	transporter	NOUN
admet-387	105	3	c	c	NOUN
admet-387	105	4	-	-	PUNCT
admet-387	105	5	terminal	terminal	ADJ
admet-387	105	6	sequence	sequence	NOUN
admet-387	105	7	reference	reference	NOUN
admet-387	105	8	kidney	kidney	NOUN
admet-387	105	9	urat1	urat1	PROPN
admet-387	105	10	/	/	SYM
admet-387	105	11	slc22a12	slc22a12	NOUN
admet-387	105	12	stqf	stqf	ADP
admet-387	105	13	anzai	anzai	ADJ
admet-387	105	14	2004	2004	NUM
admet-387	106	1	[	[	X
admet-387	106	2	31	31	NUM
admet-387	106	3	]	]	X
admet-387	106	4	oat4	oat4	PROPN
admet-387	106	5	/	/	SYM
admet-387	106	6	slc22a11	slc22a11	PROPN
admet-387	106	7	stsl	stsl	PROPN
admet-387	106	8	miyazaki	miyazaki	PROPN
admet-387	106	9	2005	2005	NUM
admet-387	107	1	[	[	X
admet-387	107	2	32	32	NUM
admet-387	107	3	]	]	SYM
admet-387	107	4	oat10	oat10	ADJ
admet-387	107	5	/	/	SYM
admet-387	107	6	slc22a13	slc22a13	NOUN
admet-387	107	7	styf	styf	NOUN
admet-387	107	8	bahn	bahn	NOUN
admet-387	107	9	2008	2008	NUM
admet-387	108	1	[	[	X
admet-387	108	2	28	28	NUM
admet-387	108	3	]	]	X
admet-387	108	4	a	a	DET
admet-387	108	5	smct1	smct1	NOUN
admet-387	108	6	/	/	SYM
admet-387	108	7	slc5a8	slc5a8	NOUN
admet-387	108	8	gtrl	gtrl	NOUN
admet-387	108	9	kanai	kanai	PROPN
admet-387	108	10	2008	2008	NUM
admet-387	109	1	[	[	X
admet-387	109	2	33	33	NUM
admet-387	109	3	]	]	SYM
admet-387	109	4	smct2	smct2	NOUN
admet-387	109	5	/	/	SYM
admet-387	109	6	slc5a12	slc5a12	PROPN
admet-387	109	7	tthf	tthf	PROPN
admet-387	109	8	kanai	kanai	PROPN
admet-387	109	9	2008	2008	NUM
admet-387	109	10	[	[	X
admet-387	109	11	33	33	NUM
admet-387	109	12	]	]	X
admet-387	109	13	npt1	npt1	PROPN
admet-387	109	14	/	/	SYM
admet-387	109	15	slc17a1	slc17a1	PROPN
admet-387	109	16	htrl	htrl	NOUN
admet-387	109	17	gisler	gisler	NOUN
admet-387	109	18	2003	2003	NUM
admet-387	109	19	[	[	X
admet-387	109	20	34	34	NUM
admet-387	109	21	]	]	X
admet-387	109	22	npt4	npt4	NOUN
admet-387	109	23	/	/	SYM
admet-387	109	24	slc17a3	slc17a3	NOUN
admet-387	109	25	ltrl	ltrl	NOUN
admet-387	109	26	jutabha	jutabha	NOUN
admet-387	109	27	2010	2010	NUM
admet-387	110	1	[	[	X
admet-387	110	2	35	35	NUM
admet-387	110	3	]	]	PUNCT
admet-387	110	4	a	a	DET
admet-387	110	5	mrp2	mrp2	PROPN
admet-387	110	6	/	/	SYM
admet-387	110	7	abcc2	abcc2	PROPN
admet-387	110	8	stkf	stkf	PROPN
admet-387	110	9	kocher	kocher	PROPN
admet-387	110	10	1999	1999	NUM
admet-387	111	1	[	[	X
admet-387	111	2	36	36	NUM
admet-387	111	3	]	]	X
admet-387	111	4	mrp4	mrp4	PROPN
admet-387	111	5	/	/	SYM
admet-387	111	6	abcc4	abcc4	PROPN
admet-387	111	7	etal	etal	PROPN
admet-387	111	8	park	park	NOUN
admet-387	111	9	2014	2014	NUM
admet-387	112	1	[	[	X
admet-387	112	2	37	37	NUM
admet-387	112	3	]	]	X
admet-387	112	4	nhe3	nhe3	PROPN
admet-387	112	5	/	/	SYM
admet-387	112	6	slc9a3	slc9a3	PROPN
admet-387	112	7	sthm	sthm	PROPN
admet-387	112	8	gisler	gisler	NOUN
admet-387	112	9	2003	2003	NUM
admet-387	113	1	[	[	X
admet-387	113	2	34	34	NUM
admet-387	113	3	]	]	PUNCT
admet-387	113	4	intestine	intestine	NOUN
admet-387	113	5	npt5	npt5	PROPN
admet-387	113	6	/	/	SYM
admet-387	113	7	slc17a4	slc17a4	ADJ
admet-387	113	8	fthl	fthl	ADJ
admet-387	113	9	togawa	togawa	PROPN
admet-387	113	10	2012	2012	NUM
admet-387	114	1	[	[	X
admet-387	114	2	38	38	NUM
admet-387	114	3	]	]	SYM
admet-387	114	4	b	b	X
admet-387	114	5	bcrp	bcrp	ADJ
admet-387	114	6	/	/	SYM
admet-387	114	7	abcg2	abcg2	NOUN
admet-387	114	8	*	*	PUNCT
admet-387	114	9	kkys	kkys	NOUN
admet-387	115	1	shimizu	shimizu	PROPN
admet-387	115	2	2011	2011	NUM
admet-387	116	1	[	[	X
admet-387	116	2	39	39	NUM
admet-387	116	3	]	]	PUNCT
admet-387	116	4	*	*	PUNCT
admet-387	116	5	bcrp	bcrp	PROPN
admet-387	116	6	may	may	AUX
admet-387	116	7	interact	interact	VERB
admet-387	116	8	with	with	ADP
admet-387	116	9	pdzk1	pdzk1	NOUN
admet-387	116	10	in	in	ADP
admet-387	116	11	a	a	DET
admet-387	116	12	non	non	ADJ
admet-387	116	13	-	-	ADJ
admet-387	116	14	classical	classical	ADJ
admet-387	116	15	way	way	NOUN
admet-387	116	16	via	via	ADP
admet-387	116	17	an	an	DET
admet-387	116	18	internal	internal	ADJ
admet-387	116	19	sequence	sequence	NOUN
admet-387	116	20	.	.	PUNCT
admet-387	117	1	a	a	DET
admet-387	117	2	,	,	PUNCT
admet-387	117	3	b	b	PROPN
admet-387	117	4	apical	apical	ADJ
admet-387	117	5	membrane	membrane	NOUN
admet-387	117	6	localization	localization	NOUN
admet-387	117	7	in	in	ADP
admet-387	117	8	rptec	rptec	ADJ
admet-387	117	9	a	a	PRON
admet-387	117	10	or	or	CCONJ
admet-387	117	11	enterocytes	enterocyte	VERB
admet-387	117	12	b	b	PROPN
admet-387	117	13	.	.	PROPN
admet-387	117	14	presumed	presume	VERB
admet-387	117	15	to	to	PART
admet-387	117	16	interact	interact	VERB
admet-387	117	17	with	with	ADP
admet-387	117	18	pdzk1	pdzk1	NOUN
admet-387	117	19	based	base	VERB
admet-387	117	20	on	on	ADP
admet-387	117	21	c	c	NOUN
admet-387	117	22	-	-	PUNCT
admet-387	117	23	terminal	terminal	ADJ
admet-387	117	24	sequence	sequence	NOUN
admet-387	117	25	.	.	PUNCT
admet-387	118	1	admet	admet	PROPN
admet-387	118	2	&	&	CCONJ
admet-387	118	3	dmpk	dmpk	PROPN
admet-387	118	4	5(2	5(2	NUM
admet-387	118	5	)	)	PUNCT
admet-387	118	6	(	(	PUNCT
admet-387	118	7	2017	2017	NUM
admet-387	118	8	)	)	PUNCT
admet-387	118	9	59	59	NUM
admet-387	118	10	-	-	SYM
admet-387	118	11	74	74	NUM
admet-387	118	12	uric	uric	ADJ
admet-387	118	13	acid	acid	NOUN
admet-387	118	14	transporter	transporter	NOUN
admet-387	118	15	inhibitors	inhibitor	NOUN
admet-387	118	16	for	for	ADP
admet-387	118	17	gout	gout	NOUN
admet-387	118	18	doi	doi	NOUN
admet-387	118	19	:	:	PUNCT
admet-387	118	20	10.5599	10.5599	NUM
admet-387	118	21	/	/	SYM
admet-387	118	22	admet.5.1.387	admet.5.1.387	NUM
admet-387	118	23	65	65	NUM
admet-387	118	24	oat1	oat1	PROPN
admet-387	118	25	and	and	CCONJ
admet-387	118	26	oat3	oat3	PROPN
admet-387	118	27	oat1	oat1	PROPN
admet-387	118	28	/	/	SYM
admet-387	118	29	slc22a6	slc22a6	PROPN
admet-387	118	30	and	and	CCONJ
admet-387	118	31	oat3	oat3	PROPN
admet-387	118	32	/	/	SYM
admet-387	118	33	slc22a8	slc22a8	NOUN
admet-387	118	34	are	be	AUX
admet-387	118	35	important	important	ADJ
admet-387	118	36	transporters	transporter	NOUN
admet-387	118	37	involved	involve	VERB
admet-387	118	38	in	in	ADP
admet-387	118	39	the	the	DET
admet-387	118	40	renal	renal	ADJ
admet-387	118	41	secretion	secretion	NOUN
admet-387	118	42	of	of	ADP
admet-387	118	43	many	many	ADJ
admet-387	118	44	drugs	drug	NOUN
admet-387	118	45	.	.	PUNCT
admet-387	119	1	they	they	PRON
admet-387	119	2	are	be	AUX
admet-387	119	3	localized	localize	VERB
admet-387	119	4	to	to	ADP
admet-387	119	5	the	the	DET
admet-387	119	6	basolateral	basolateral	ADJ
admet-387	119	7	membranes	membrane	NOUN
admet-387	119	8	of	of	ADP
admet-387	119	9	rptecs	rptec	NOUN
admet-387	119	10	and	and	CCONJ
admet-387	119	11	transport	transport	NOUN
admet-387	119	12	urate	urate	NOUN
admet-387	119	13	in	in	ADP
admet-387	119	14	vitro	vitro	NOUN
admet-387	119	15	,	,	PUNCT
admet-387	119	16	suggesting	suggest	VERB
admet-387	119	17	that	that	SCONJ
admet-387	119	18	they	they	PRON
admet-387	119	19	are	be	AUX
admet-387	119	20	involved	involve	VERB
admet-387	119	21	in	in	ADP
admet-387	119	22	urate	urate	NOUN
admet-387	119	23	secretion	secretion	NOUN
admet-387	119	24	in	in	ADP
admet-387	119	25	vivo	vivo	NOUN
admet-387	119	26	[	[	X
admet-387	119	27	40	40	NUM
admet-387	119	28	]	]	PUNCT
admet-387	119	29	.	.	PUNCT
admet-387	120	1	however	however	ADV
admet-387	120	2	,	,	PUNCT
admet-387	120	3	oat1	oat1	PROPN
admet-387	120	4	and	and	CCONJ
admet-387	120	5	oat3	oat3	PROPN
admet-387	120	6	show	show	VERB
admet-387	120	7	no	no	DET
admet-387	120	8	genetic	genetic	ADJ
admet-387	120	9	association	association	NOUN
admet-387	120	10	with	with	ADP
admet-387	120	11	sua	sua	PROPN
admet-387	120	12	levels	level	NOUN
admet-387	120	13	,	,	PUNCT
admet-387	120	14	and	and	CCONJ
admet-387	120	15	there	there	PRON
admet-387	120	16	is	be	VERB
admet-387	120	17	no	no	DET
admet-387	120	18	solid	solid	ADJ
admet-387	120	19	evidence	evidence	NOUN
admet-387	120	20	supporting	support	VERB
admet-387	120	21	a	a	DET
admet-387	120	22	role	role	NOUN
admet-387	120	23	in	in	ADP
admet-387	120	24	uric	uric	ADJ
admet-387	120	25	acid	acid	NOUN
admet-387	120	26	homeostasis	homeostasis	NOUN
admet-387	120	27	in	in	ADP
admet-387	120	28	humans	human	NOUN
admet-387	120	29	.	.	PUNCT
admet-387	121	1	oat1	oat1	PROPN
admet-387	121	2	and	and	CCONJ
admet-387	121	3	oat3	oat3	PROPN
admet-387	121	4	are	be	AUX
admet-387	121	5	in	in	ADP
admet-387	121	6	the	the	DET
admet-387	121	7	same	same	ADJ
admet-387	121	8	transporter	transporter	NOUN
admet-387	121	9	family	family	NOUN
admet-387	121	10	and	and	CCONJ
admet-387	121	11	have	have	VERB
admet-387	121	12	a	a	DET
admet-387	121	13	46	46	NUM
admet-387	121	14	%	%	NOUN
admet-387	121	15	and	and	CCONJ
admet-387	121	16	42	42	NUM
admet-387	121	17	%	%	NOUN
admet-387	121	18	amino	amino	NOUN
admet-387	121	19	acid	acid	NOUN
admet-387	121	20	identity	identity	NOUN
admet-387	121	21	with	with	ADP
admet-387	121	22	urat1	urat1	NOUN
admet-387	122	1	[	[	X
admet-387	122	2	41	41	NUM
admet-387	122	3	]	]	PUNCT
admet-387	122	4	.	.	PUNCT
admet-387	123	1	the	the	DET
admet-387	123	2	urat1	urat1	PROPN
admet-387	123	3	inhibitor	inhibitor	NOUN
admet-387	123	4	probenecid	probenecid	PROPN
admet-387	123	5	also	also	ADV
admet-387	123	6	inhibits	inhibit	VERB
admet-387	123	7	oat1	oat1	PROPN
admet-387	123	8	and	and	CCONJ
admet-387	123	9	oat3	oat3	PROPN
admet-387	123	10	,	,	PUNCT
admet-387	123	11	leading	lead	VERB
admet-387	123	12	to	to	ADP
admet-387	123	13	oat1/3dependent	oat1/3dependent	NOUN
admet-387	123	14	drug	drug	NOUN
admet-387	123	15	-	-	PUNCT
admet-387	123	16	drug	drug	NOUN
admet-387	123	17	interactions	interaction	NOUN
admet-387	123	18	that	that	PRON
admet-387	123	19	limits	limit	VERB
admet-387	123	20	its	its	PRON
admet-387	123	21	use	use	NOUN
admet-387	123	22	.	.	PUNCT
admet-387	124	1	the	the	DET
admet-387	124	2	urat1	urat1	PROPN
admet-387	124	3	inhibitor	inhibitor	NOUN
admet-387	124	4	lesinurad	lesinurad	NOUN
admet-387	124	5	has	have	VERB
admet-387	124	6	detectable	detectable	ADJ
admet-387	124	7	interactions	interaction	NOUN
admet-387	124	8	with	with	ADP
admet-387	124	9	oat1	oat1	NOUN
admet-387	124	10	and	and	CCONJ
admet-387	124	11	oat3	oat3	PROPN
admet-387	124	12	in	in	ADP
admet-387	124	13	vitro	vitro	NOUN
admet-387	124	14	,	,	PUNCT
admet-387	124	15	but	but	CCONJ
admet-387	124	16	in	in	ADP
admet-387	124	17	contrast	contrast	NOUN
admet-387	124	18	to	to	ADP
admet-387	124	19	probenecid	probenecid	PROPN
admet-387	124	20	has	have	VERB
admet-387	124	21	no	no	DET
admet-387	124	22	clinically	clinically	ADV
admet-387	124	23	relevant	relevant	ADJ
admet-387	124	24	oat1/3dependent	oat1/3dependent	NOUN
admet-387	124	25	drug	drug	NOUN
admet-387	124	26	-	-	PUNCT
admet-387	124	27	drug	drug	NOUN
admet-387	124	28	interactions	interaction	NOUN
admet-387	124	29	[	[	X
admet-387	124	30	42	42	NUM
admet-387	124	31	,	,	PUNCT
admet-387	124	32	43	43	NUM
admet-387	124	33	]	]	PUNCT
admet-387	124	34	.	.	PUNCT
admet-387	125	1	because	because	SCONJ
admet-387	125	2	of	of	ADP
admet-387	125	3	the	the	DET
admet-387	125	4	relatedness	relatedness	NOUN
admet-387	125	5	to	to	ADP
admet-387	125	6	urat1	urat1	PROPN
admet-387	125	7	,	,	PUNCT
admet-387	125	8	all	all	PRON
admet-387	125	9	urat1	urat1	NOUN
admet-387	125	10	inhibitors	inhibitor	NOUN
admet-387	125	11	under	under	ADP
admet-387	125	12	evaluation	evaluation	NOUN
admet-387	125	13	for	for	ADP
admet-387	125	14	treatment	treatment	NOUN
admet-387	125	15	of	of	ADP
admet-387	125	16	hyperuricemia	hyperuricemia	NOUN
admet-387	125	17	associated	associate	VERB
admet-387	125	18	with	with	ADP
admet-387	125	19	gout	gout	NOUN
admet-387	125	20	should	should	AUX
admet-387	125	21	be	be	AUX
admet-387	125	22	evaluated	evaluate	VERB
admet-387	125	23	against	against	ADP
admet-387	125	24	oat1	oat1	PROPN
admet-387	125	25	and	and	CCONJ
admet-387	125	26	oat3	oat3	PROPN
admet-387	125	27	.	.	PUNCT
admet-387	126	1	npt1	npt1	PROPN
admet-387	126	2	,	,	PUNCT
admet-387	126	3	npt4	npt4	NOUN
admet-387	126	4	and	and	CCONJ
admet-387	126	5	npt5	npt5	PROPN
admet-387	126	6	npt1	npt1	PROPN
admet-387	126	7	/	/	SYM
admet-387	126	8	slc17a1	slc17a1	PROPN
admet-387	126	9	,	,	PUNCT
admet-387	126	10	npt4	npt4	NOUN
admet-387	126	11	/	/	SYM
admet-387	126	12	slc17a3	slc17a3	NOUN
admet-387	126	13	,	,	PUNCT
admet-387	126	14	and	and	CCONJ
admet-387	126	15	npt5	npt5	PROPN
admet-387	126	16	/	/	SYM
admet-387	126	17	slc17a4	slc17a4	PROPN
admet-387	126	18	(	(	PUNCT
admet-387	126	19	formerly	formerly	ADV
admet-387	126	20	known	know	VERB
admet-387	126	21	as	as	ADP
admet-387	126	22	npt	npt	PROPN
admet-387	126	23	-	-	PUNCT
admet-387	126	24	like	like	ADJ
admet-387	126	25	)	)	PUNCT
admet-387	126	26	occur	occur	VERB
admet-387	126	27	in	in	ADP
admet-387	126	28	a	a	DET
admet-387	126	29	gene	gene	NOUN
admet-387	126	30	cluster	cluster	NOUN
admet-387	126	31	with	with	ADP
admet-387	126	32	a	a	DET
admet-387	126	33	strong	strong	ADJ
admet-387	126	34	genetic	genetic	ADJ
admet-387	126	35	association	association	NOUN
admet-387	126	36	with	with	ADP
admet-387	126	37	sua	sua	PROPN
admet-387	126	38	levels	level	NOUN
admet-387	126	39	[	[	X
admet-387	126	40	7	7	NUM
admet-387	126	41	]	]	PUNCT
admet-387	126	42	.	.	PUNCT
admet-387	127	1	npt1	npt1	PROPN
admet-387	127	2	and	and	CCONJ
admet-387	127	3	npt4	npt4	PROPN
admet-387	127	4	localize	localize	VERB
admet-387	127	5	to	to	ADP
admet-387	127	6	the	the	DET
admet-387	127	7	apical	apical	ADJ
admet-387	127	8	membrane	membrane	NOUN
admet-387	127	9	of	of	ADP
admet-387	127	10	rptecs	rptec	NOUN
admet-387	127	11	and	and	CCONJ
admet-387	127	12	are	be	AUX
admet-387	127	13	hypothesized	hypothesize	VERB
admet-387	127	14	to	to	PART
admet-387	127	15	export	export	VERB
admet-387	127	16	urate	urate	NOUN
admet-387	127	17	into	into	ADP
admet-387	127	18	the	the	DET
admet-387	127	19	tubule	tubule	NOUN
admet-387	127	20	lumen	luman	NOUN
admet-387	127	21	as	as	ADP
admet-387	127	22	part	part	NOUN
admet-387	127	23	of	of	ADP
admet-387	127	24	the	the	DET
admet-387	127	25	urate	urate	NOUN
admet-387	127	26	secretory	secretory	ADJ
admet-387	127	27	pathway	pathway	NOUN
admet-387	127	28	.	.	PUNCT
admet-387	128	1	support	support	NOUN
admet-387	128	2	for	for	ADP
admet-387	128	3	this	this	DET
admet-387	128	4	functional	functional	ADJ
admet-387	128	5	role	role	NOUN
admet-387	128	6	comes	come	VERB
admet-387	128	7	from	from	ADP
admet-387	128	8	the	the	DET
admet-387	128	9	identification	identification	NOUN
admet-387	128	10	and	and	CCONJ
admet-387	128	11	analysis	analysis	NOUN
admet-387	128	12	of	of	ADP
admet-387	128	13	missense	missense	NOUN
admet-387	128	14	mutations	mutation	NOUN
admet-387	128	15	involved	involve	VERB
admet-387	128	16	in	in	ADP
admet-387	128	17	hyperuricemia	hyperuricemia	NOUN
admet-387	128	18	and/or	and/or	CCONJ
admet-387	128	19	gout	gout	NOUN
admet-387	128	20	that	that	PRON
admet-387	128	21	exhibit	exhibit	VERB
admet-387	128	22	altered	alter	VERB
admet-387	128	23	urate	urate	NOUN
admet-387	128	24	transport	transport	NOUN
admet-387	128	25	activities	activity	NOUN
admet-387	128	26	[	[	X
admet-387	128	27	35	35	NUM
admet-387	128	28	,	,	PUNCT
admet-387	128	29	44	44	NUM
admet-387	128	30	-	-	SYM
admet-387	128	31	47	47	NUM
admet-387	128	32	]	]	PUNCT
admet-387	128	33	.	.	PUNCT
admet-387	129	1	moreover	moreover	ADV
admet-387	129	2	,	,	PUNCT
admet-387	129	3	it	it	PRON
admet-387	129	4	has	have	AUX
admet-387	129	5	been	be	AUX
admet-387	129	6	suggested	suggest	VERB
admet-387	129	7	that	that	SCONJ
admet-387	129	8	hyperuricemia	hyperuricemia	NOUN
admet-387	129	9	induced	induce	VERB
admet-387	129	10	by	by	ADP
admet-387	129	11	diuretics	diuretic	NOUN
admet-387	129	12	may	may	AUX
admet-387	129	13	be	be	AUX
admet-387	129	14	due	due	ADJ
admet-387	129	15	to	to	ADP
admet-387	129	16	inhibition	inhibition	NOUN
admet-387	129	17	of	of	ADP
admet-387	129	18	npt4	npt4	NOUN
admet-387	129	19	[	[	X
admet-387	129	20	45	45	NUM
admet-387	129	21	]	]	PUNCT
admet-387	129	22	.	.	PUNCT
admet-387	130	1	meanwhile	meanwhile	ADV
admet-387	130	2	,	,	PUNCT
admet-387	130	3	npt5	npt5	PROPN
admet-387	130	4	is	be	AUX
admet-387	130	5	a	a	DET
admet-387	130	6	urate	urate	NOUN
admet-387	130	7	exporter	exporter	NOUN
admet-387	130	8	that	that	PRON
admet-387	130	9	expressed	express	VERB
admet-387	130	10	on	on	ADP
admet-387	130	11	the	the	DET
admet-387	130	12	apical	apical	ADJ
admet-387	130	13	surface	surface	NOUN
admet-387	130	14	of	of	ADP
admet-387	130	15	intestinal	intestinal	ADJ
admet-387	130	16	epithelial	epithelial	ADJ
admet-387	130	17	cells	cell	NOUN
admet-387	130	18	,	,	PUNCT
admet-387	130	19	suggesting	suggest	VERB
admet-387	130	20	a	a	DET
admet-387	130	21	role	role	NOUN
admet-387	130	22	in	in	ADP
admet-387	130	23	intestinal	intestinal	ADJ
admet-387	130	24	urate	urate	NOUN
admet-387	130	25	secretion	secretion	NOUN
admet-387	130	26	[	[	X
admet-387	130	27	38	38	NUM
admet-387	130	28	]	]	PUNCT
admet-387	130	29	.	.	PUNCT
admet-387	131	1	mrp4	mrp4	PROPN
admet-387	131	2	multi	multi	ADJ
admet-387	131	3	-	-	ADJ
admet-387	131	4	resistance	resistance	NOUN
admet-387	131	5	protein	protein	NOUN
admet-387	131	6	4	4	NUM
admet-387	131	7	(	(	PUNCT
admet-387	131	8	mrp4	mrp4	NOUN
admet-387	131	9	/	/	SYM
admet-387	131	10	abcc4	abcc4	NOUN
admet-387	131	11	)	)	PUNCT
admet-387	131	12	transports	transport	VERB
admet-387	131	13	urate	urate	NOUN
admet-387	131	14	in	in	ADP
admet-387	131	15	vitro	vitro	NOUN
admet-387	131	16	,	,	PUNCT
admet-387	131	17	localizes	localize	VERB
admet-387	131	18	to	to	ADP
admet-387	131	19	the	the	DET
admet-387	131	20	apical	apical	ADJ
admet-387	131	21	membranes	membrane	NOUN
admet-387	131	22	of	of	ADP
admet-387	131	23	rptec	rptec	NOUN
admet-387	131	24	,	,	PUNCT
admet-387	131	25	and	and	CCONJ
admet-387	131	26	was	be	AUX
admet-387	131	27	recently	recently	ADV
admet-387	131	28	shown	show	VERB
admet-387	131	29	to	to	PART
admet-387	131	30	be	be	AUX
admet-387	131	31	genetically	genetically	ADV
admet-387	131	32	associated	associate	VERB
admet-387	131	33	with	with	ADP
admet-387	131	34	gout	gout	NOUN
admet-387	131	35	and	and	CCONJ
admet-387	131	36	renal	renal	ADJ
admet-387	131	37	excretion	excretion	NOUN
admet-387	131	38	of	of	ADP
admet-387	131	39	uric	uric	ADJ
admet-387	131	40	acid	acid	NOUN
admet-387	132	1	[	[	X
admet-387	132	2	8	8	NUM
admet-387	132	3	]	]	PUNCT
admet-387	132	4	.	.	PUNCT
admet-387	133	1	consistent	consistent	ADJ
admet-387	133	2	with	with	ADP
admet-387	133	3	its	its	PRON
admet-387	133	4	proposed	propose	VERB
admet-387	133	5	role	role	NOUN
admet-387	133	6	as	as	ADP
admet-387	133	7	an	an	DET
admet-387	133	8	efflux	efflux	NOUN
admet-387	133	9	transporter	transporter	NOUN
admet-387	133	10	involved	involve	VERB
admet-387	133	11	in	in	ADP
admet-387	133	12	the	the	DET
admet-387	133	13	renal	renal	ADJ
admet-387	133	14	secretion	secretion	NOUN
admet-387	133	15	of	of	ADP
admet-387	133	16	urate	urate	NOUN
admet-387	133	17	,	,	PUNCT
admet-387	133	18	a	a	DET
admet-387	133	19	nonsynonymous	nonsynonymous	ADJ
admet-387	133	20	variant	variant	NOUN
admet-387	133	21	p1036l	p1036l	NOUN
admet-387	133	22	of	of	ADP
admet-387	133	23	mrp4	mrp4	NOUN
admet-387	133	24	had	have	AUX
admet-387	133	25	reduced	reduce	VERB
admet-387	133	26	uric	uric	ADJ
admet-387	133	27	acid	acid	NOUN
admet-387	133	28	transport	transport	NOUN
admet-387	133	29	activity	activity	NOUN
admet-387	133	30	[	[	X
admet-387	133	31	6	6	NUM
admet-387	133	32	]	]	PUNCT
admet-387	133	33	.	.	PUNCT
admet-387	134	1	diuretics	diuretic	NOUN
admet-387	134	2	have	have	AUX
admet-387	134	3	been	be	AUX
admet-387	134	4	proposed	propose	VERB
admet-387	134	5	to	to	PART
admet-387	134	6	elevate	elevate	VERB
admet-387	134	7	sua	sua	PROPN
admet-387	134	8	levels	level	NOUN
admet-387	134	9	through	through	ADP
admet-387	134	10	inhibition	inhibition	NOUN
admet-387	134	11	of	of	ADP
admet-387	134	12	mrp4	mrp4	NOUN
admet-387	135	1	[	[	X
admet-387	135	2	48	48	NUM
admet-387	135	3	]	]	PUNCT
admet-387	135	4	.	.	PUNCT
admet-387	136	1	abcg2	abcg2	PROPN
admet-387	136	2	atp	atp	NOUN
admet-387	136	3	-	-	PUNCT
admet-387	136	4	binding	bind	VERB
admet-387	136	5	cassette	cassette	NOUN
admet-387	136	6	sub	sub	NOUN
admet-387	136	7	-	-	ADJ
admet-387	136	8	family	family	ADJ
admet-387	136	9	g	g	PROPN
admet-387	136	10	member	member	NOUN
admet-387	136	11	2	2	NUM
admet-387	136	12	(	(	PUNCT
admet-387	136	13	abcg2	abcg2	NOUN
admet-387	136	14	,	,	PUNCT
admet-387	136	15	also	also	ADV
admet-387	136	16	known	know	VERB
admet-387	136	17	as	as	ADP
admet-387	136	18	breast	breast	NOUN
admet-387	136	19	cancer	cancer	NOUN
admet-387	136	20	-	-	PUNCT
admet-387	136	21	resistance	resistance	NOUN
admet-387	136	22	protein	protein	NOUN
admet-387	136	23	or	or	CCONJ
admet-387	136	24	bcrp	bcrp	ADV
admet-387	136	25	,	,	PUNCT
admet-387	136	26	encoded	encode	VERB
admet-387	136	27	by	by	ADP
admet-387	136	28	the	the	DET
admet-387	136	29	abcg2	abcg2	NOUN
admet-387	136	30	gene	gene	NOUN
admet-387	136	31	)	)	PUNCT
admet-387	136	32	is	be	AUX
admet-387	136	33	an	an	DET
admet-387	136	34	atp	atp	NOUN
admet-387	136	35	-	-	PUNCT
admet-387	136	36	dependent	dependent	ADJ
admet-387	136	37	transporter	transporter	NOUN
admet-387	136	38	that	that	PRON
admet-387	136	39	is	be	AUX
admet-387	136	40	expressed	express	VERB
admet-387	136	41	on	on	ADP
admet-387	136	42	the	the	DET
admet-387	136	43	apical	apical	ADJ
admet-387	136	44	membranes	membrane	NOUN
admet-387	136	45	of	of	ADP
admet-387	136	46	rptec	rptec	ADJ
admet-387	136	47	and	and	CCONJ
admet-387	136	48	intestinal	intestinal	ADJ
admet-387	136	49	epithelia	epithelium	NOUN
admet-387	136	50	,	,	PUNCT
admet-387	136	51	involved	involve	VERB
admet-387	136	52	in	in	ADP
admet-387	136	53	the	the	DET
admet-387	136	54	export	export	NOUN
admet-387	136	55	of	of	ADP
admet-387	136	56	urate	urate	NOUN
admet-387	136	57	(	(	PUNCT
admet-387	136	58	secretion	secretion	NOUN
admet-387	136	59	)	)	PUNCT
admet-387	136	60	,	,	PUNCT
admet-387	136	61	and	and	CCONJ
admet-387	136	62	with	with	ADP
admet-387	136	63	a	a	DET
admet-387	136	64	strong	strong	ADJ
admet-387	136	65	genetic	genetic	ADJ
admet-387	136	66	association	association	NOUN
admet-387	136	67	with	with	ADP
admet-387	136	68	sua	sua	PROPN
admet-387	136	69	levels	level	NOUN
admet-387	136	70	and	and	CCONJ
admet-387	136	71	gout	gout	NOUN
admet-387	136	72	.	.	PUNCT
admet-387	137	1	humans	human	NOUN
admet-387	137	2	carrying	carry	VERB
admet-387	137	3	a	a	DET
admet-387	137	4	common	common	ADJ
admet-387	137	5	genetic	genetic	ADJ
admet-387	137	6	variant	variant	NOUN
admet-387	137	7	,	,	PUNCT
admet-387	137	8	q141k	q141k	PROPN
admet-387	137	9	,	,	PUNCT
admet-387	137	10	which	which	PRON
admet-387	137	11	exhibits	exhibit	VERB
admet-387	137	12	reduced	reduced	ADJ
admet-387	137	13	expression	expression	NOUN
admet-387	137	14	and	and	CCONJ
admet-387	137	15	activity	activity	NOUN
admet-387	137	16	,	,	PUNCT
admet-387	137	17	have	have	AUX
admet-387	137	18	elevated	elevate	VERB
admet-387	137	19	sua	sua	NOUN
admet-387	137	20	levels	level	NOUN
admet-387	137	21	and	and	CCONJ
admet-387	137	22	elevated	elevate	VERB
admet-387	137	23	renal	renal	ADJ
admet-387	137	24	excretion	excretion	NOUN
admet-387	137	25	of	of	ADP
admet-387	137	26	uric	uric	ADJ
admet-387	137	27	acid	acid	NOUN
admet-387	137	28	,	,	PUNCT
admet-387	137	29	supporting	support	VERB
admet-387	137	30	a	a	DET
admet-387	137	31	role	role	NOUN
admet-387	137	32	for	for	ADP
admet-387	137	33	abcg2	abcg2	NOUN
admet-387	137	34	in	in	ADP
admet-387	137	35	the	the	DET
admet-387	137	36	intestinal	intestinal	ADJ
admet-387	137	37	secretion	secretion	NOUN
admet-387	137	38	of	of	ADP
admet-387	137	39	uric	uric	ADJ
admet-387	137	40	acid	acid	NOUN
admet-387	137	41	[	[	X
admet-387	137	42	49	49	NUM
admet-387	137	43	]	]	PUNCT
admet-387	137	44	.	.	PUNCT
admet-387	138	1	abcg2	abcg2	NOUN
admet-387	138	2	is	be	AUX
admet-387	138	3	strongly	strongly	ADV
admet-387	138	4	expressed	express	VERB
admet-387	138	5	in	in	ADP
admet-387	138	6	the	the	DET
admet-387	138	7	intestine	intestine	NOUN
admet-387	138	8	and	and	CCONJ
admet-387	138	9	is	be	AUX
admet-387	138	10	weakly	weakly	ADV
admet-387	138	11	expressed	express	VERB
admet-387	138	12	in	in	ADP
admet-387	138	13	the	the	DET
admet-387	138	14	kidneys	kidney	NOUN
admet-387	138	15	,	,	PUNCT
admet-387	138	16	suggesting	suggest	VERB
admet-387	138	17	that	that	SCONJ
admet-387	138	18	it	it	PRON
admet-387	138	19	primarily	primarily	ADV
admet-387	138	20	functions	function	VERB
admet-387	138	21	to	to	PART
admet-387	138	22	transport	transport	VERB
admet-387	138	23	urate	urate	NOUN
admet-387	138	24	into	into	ADP
admet-387	138	25	the	the	DET
admet-387	138	26	intestinal	intestinal	ADJ
admet-387	138	27	lumen	luman	NOUN
admet-387	138	28	.	.	PUNCT
admet-387	139	1	the	the	DET
admet-387	139	2	strong	strong	ADJ
admet-387	139	3	genetic	genetic	ADJ
admet-387	139	4	association	association	NOUN
admet-387	139	5	with	with	ADP
admet-387	139	6	sua	sua	PROPN
admet-387	139	7	and	and	CCONJ
admet-387	139	8	gout	gout	NOUN
admet-387	139	9	suggests	suggest	VERB
admet-387	139	10	that	that	SCONJ
admet-387	139	11	drugs	drug	NOUN
admet-387	139	12	that	that	PRON
admet-387	139	13	activate	activate	VERB
admet-387	139	14	abcg2	abcg2	NOUN
admet-387	139	15	could	could	AUX
admet-387	139	16	serve	serve	VERB
admet-387	139	17	as	as	ADP
admet-387	139	18	gout	gout	NOUN
admet-387	139	19	therapies	therapy	NOUN
admet-387	139	20	.	.	PUNCT
admet-387	140	1	evolution	evolution	NOUN
admet-387	140	2	of	of	ADP
admet-387	140	3	gout	gout	NOUN
admet-387	140	4	in	in	ADP
admet-387	140	5	humans	human	NOUN
admet-387	140	6	uric	uric	ADJ
admet-387	140	7	acid	acid	PROPN
admet-387	140	8	is	be	AUX
admet-387	140	9	a	a	DET
admet-387	140	10	small	small	ADJ
admet-387	140	11	,	,	PUNCT
admet-387	140	12	seemingly	seemingly	ADV
admet-387	140	13	innocuous	innocuous	ADJ
admet-387	140	14	waste	waste	NOUN
admet-387	140	15	compound	compound	NOUN
admet-387	140	16	found	find	VERB
admet-387	140	17	mainly	mainly	ADV
admet-387	140	18	in	in	ADP
admet-387	140	19	the	the	DET
admet-387	140	20	excreta	excreta	NOUN
admet-387	140	21	from	from	ADP
admet-387	140	22	many	many	ADJ
admet-387	140	23	different	different	ADJ
admet-387	140	24	species	specie	NOUN
admet-387	140	25	.	.	PUNCT
admet-387	141	1	biochemically	biochemically	ADV
admet-387	141	2	,	,	PUNCT
admet-387	141	3	this	this	DET
admet-387	141	4	simple	simple	ADJ
admet-387	141	5	compound	compound	NOUN
admet-387	141	6	is	be	AUX
admet-387	141	7	merely	merely	ADV
admet-387	141	8	one	one	NUM
admet-387	141	9	step	step	NOUN
admet-387	141	10	in	in	ADP
admet-387	141	11	the	the	DET
admet-387	141	12	removal	removal	NOUN
admet-387	141	13	pathway	pathway	NOUN
admet-387	141	14	for	for	ADP
admet-387	141	15	tan	tan	PROPN
admet-387	141	16	and	and	CCONJ
admet-387	141	17	miner	miner	NOUN
admet-387	141	18	admet	admet	PROPN
admet-387	141	19	&	&	CCONJ
admet-387	141	20	dmpk	dmpk	PROPN
admet-387	141	21	5(2	5(2	NUM
admet-387	141	22	)	)	PUNCT
admet-387	141	23	(	(	PUNCT
admet-387	141	24	2017	2017	NUM
admet-387	141	25	)	)	PUNCT
admet-387	141	26	59	59	NUM
admet-387	141	27	-	-	SYM
admet-387	141	28	74	74	NUM
admet-387	141	29	66	66	NUM
admet-387	141	30	nitrogenous	nitrogenous	ADJ
admet-387	141	31	wastes	waste	NOUN
admet-387	141	32	in	in	ADP
admet-387	141	33	reptiles	reptile	NOUN
admet-387	141	34	and	and	CCONJ
admet-387	141	35	birds	bird	NOUN
admet-387	141	36	and	and	CCONJ
admet-387	141	37	for	for	ADP
admet-387	141	38	purines	purine	NOUN
admet-387	141	39	in	in	ADP
admet-387	141	40	humans	human	NOUN
admet-387	141	41	.	.	PUNCT
admet-387	142	1	the	the	DET
admet-387	142	2	degradation	degradation	NOUN
admet-387	142	3	of	of	ADP
admet-387	142	4	purines	purine	NOUN
admet-387	142	5	from	from	ADP
admet-387	142	6	nucleic	nucleic	ADJ
admet-387	142	7	acid	acid	NOUN
admet-387	142	8	results	result	NOUN
admet-387	142	9	in	in	ADP
admet-387	142	10	the	the	DET
admet-387	142	11	production	production	NOUN
admet-387	142	12	of	of	ADP
admet-387	142	13	uric	uric	ADJ
admet-387	142	14	acid	acid	NOUN
admet-387	142	15	,	,	PUNCT
admet-387	142	16	which	which	PRON
admet-387	142	17	in	in	ADP
admet-387	142	18	most	most	ADJ
admet-387	142	19	mammals	mammal	NOUN
admet-387	142	20	is	be	AUX
admet-387	142	21	instantly	instantly	ADV
admet-387	142	22	converted	convert	VERB
admet-387	142	23	to	to	ADP
admet-387	142	24	allantoin	allantoin	NOUN
admet-387	142	25	by	by	ADP
admet-387	142	26	the	the	DET
admet-387	142	27	enzyme	enzyme	NOUN
admet-387	142	28	uricase	uricase	NOUN
admet-387	142	29	.	.	PUNCT
admet-387	143	1	however	however	ADV
admet-387	143	2	,	,	PUNCT
admet-387	143	3	about	about	ADV
admet-387	143	4	43	43	NUM
admet-387	143	5	million	million	NUM
admet-387	143	6	years	year	NOUN
admet-387	143	7	ago	ago	ADV
admet-387	143	8	,	,	PUNCT
admet-387	143	9	for	for	ADP
admet-387	143	10	unknown	unknown	ADJ
admet-387	143	11	but	but	CCONJ
admet-387	143	12	likely	likely	ADV
admet-387	143	13	interesting	interesting	ADJ
admet-387	143	14	reasons	reason	NOUN
admet-387	143	15	,	,	PUNCT
admet-387	143	16	selective	selective	ADJ
admet-387	143	17	pressure	pressure	NOUN
admet-387	143	18	mounted	mount	VERB
admet-387	143	19	for	for	ADP
admet-387	143	20	higher	high	ADJ
admet-387	143	21	blood	blood	NOUN
admet-387	143	22	levels	level	NOUN
admet-387	143	23	of	of	ADP
admet-387	143	24	uric	uric	ADJ
admet-387	143	25	acid	acid	NOUN
admet-387	143	26	.	.	PUNCT
admet-387	144	1	primates	primate	NOUN
admet-387	144	2	carrying	carry	VERB
admet-387	144	3	mutations	mutation	NOUN
admet-387	144	4	in	in	ADP
admet-387	144	5	the	the	DET
admet-387	144	6	uric	uric	ADJ
admet-387	144	7	acid	acid	NOUN
admet-387	144	8	handling	handling	NOUN
admet-387	144	9	pathways	pathway	NOUN
admet-387	144	10	that	that	PRON
admet-387	144	11	resulted	result	VERB
admet-387	144	12	in	in	ADP
admet-387	144	13	higher	high	ADJ
admet-387	144	14	uric	uric	ADJ
admet-387	144	15	acid	acid	NOUN
admet-387	144	16	levels	level	NOUN
admet-387	144	17	experienced	experience	VERB
admet-387	144	18	a	a	DET
admet-387	144	19	selective	selective	ADJ
admet-387	144	20	advantage	advantage	NOUN
admet-387	144	21	.	.	PUNCT
admet-387	145	1	this	this	DET
admet-387	145	2	pressure	pressure	NOUN
admet-387	145	3	continued	continue	VERB
admet-387	145	4	for	for	ADP
admet-387	145	5	20	20	NUM
admet-387	145	6	million	million	NUM
admet-387	145	7	years	year	NOUN
admet-387	145	8	during	during	ADP
admet-387	145	9	simian	simian	ADJ
admet-387	145	10	evolution	evolution	NOUN
admet-387	145	11	steadily	steadily	ADV
admet-387	145	12	decreasing	decrease	VERB
admet-387	145	13	uricase	uricase	ADJ
admet-387	145	14	activity	activity	NOUN
admet-387	145	15	and	and	CCONJ
admet-387	145	16	increasing	increase	VERB
admet-387	145	17	renal	renal	ADJ
admet-387	145	18	uric	uric	ADJ
admet-387	145	19	acid	acid	NOUN
admet-387	145	20	transporter	transporter	NOUN
admet-387	145	21	affinity	affinity	NOUN
admet-387	145	22	for	for	ADP
admet-387	145	23	uric	uric	ADJ
admet-387	145	24	acid	acid	NOUN
admet-387	145	25	,	,	PUNCT
admet-387	145	26	resulting	result	VERB
admet-387	145	27	in	in	ADP
admet-387	145	28	humans	human	NOUN
admet-387	145	29	with	with	ADP
admet-387	145	30	no	no	DET
admet-387	145	31	uricase	uricase	ADJ
admet-387	145	32	enzyme	enzyme	NOUN
admet-387	145	33	activity	activity	NOUN
admet-387	145	34	,	,	PUNCT
admet-387	145	35	a	a	DET
admet-387	145	36	high	high	ADJ
admet-387	145	37	affinity	affinity	NOUN
admet-387	145	38	renal	renal	ADJ
admet-387	145	39	uric	uric	ADJ
admet-387	145	40	acid	acid	NOUN
admet-387	145	41	reabsorbing	reabsorbing	NOUN
admet-387	145	42	transporter	transporter	NOUN
admet-387	145	43	and	and	CCONJ
admet-387	145	44	the	the	DET
admet-387	145	45	highest	high	ADJ
admet-387	145	46	uric	uric	ADJ
admet-387	145	47	acid	acid	NOUN
admet-387	145	48	levels	level	NOUN
admet-387	145	49	of	of	ADP
admet-387	145	50	any	any	DET
admet-387	145	51	animal	animal	NOUN
admet-387	145	52	in	in	ADP
admet-387	145	53	the	the	DET
admet-387	145	54	class	class	NOUN
admet-387	145	55	mammalia	mammalia	NOUN
admet-387	145	56	[	[	X
admet-387	145	57	50	50	NUM
admet-387	145	58	]	]	PUNCT
admet-387	145	59	.	.	PUNCT
admet-387	146	1	the	the	DET
admet-387	146	2	hypotheses	hypothesis	NOUN
admet-387	146	3	explaining	explain	VERB
admet-387	146	4	the	the	DET
admet-387	146	5	rise	rise	NOUN
admet-387	146	6	in	in	ADP
admet-387	146	7	sua	sua	PROPN
admet-387	146	8	are	be	AUX
admet-387	146	9	many	many	ADJ
admet-387	147	1	[	[	X
admet-387	147	2	3	3	NUM
admet-387	147	3	]	]	PUNCT
admet-387	147	4	,	,	PUNCT
admet-387	148	1	and	and	CCONJ
admet-387	148	2	may	may	AUX
admet-387	148	3	involve	involve	VERB
admet-387	148	4	enhanced	enhanced	ADJ
admet-387	148	5	energy	energy	NOUN
admet-387	148	6	storage	storage	NOUN
admet-387	148	7	in	in	ADP
admet-387	148	8	resource	resource	NOUN
admet-387	148	9	-	-	PUNCT
admet-387	148	10	constrained	constrain	VERB
admet-387	148	11	environments	environment	NOUN
admet-387	148	12	due	due	ADP
admet-387	148	13	to	to	ADP
admet-387	148	14	biochemical	biochemical	ADJ
admet-387	148	15	effects	effect	NOUN
admet-387	148	16	of	of	ADP
admet-387	148	17	uric	uric	ADJ
admet-387	148	18	acid	acid	NOUN
admet-387	148	19	on	on	ADP
admet-387	148	20	metabolism	metabolism	NOUN
admet-387	148	21	.	.	PUNCT
admet-387	149	1	these	these	DET
admet-387	149	2	same	same	ADJ
admet-387	149	3	selective	selective	ADJ
admet-387	149	4	pressures	pressure	NOUN
admet-387	149	5	no	no	ADV
admet-387	149	6	longer	long	ADV
admet-387	149	7	exist	exist	VERB
admet-387	149	8	today	today	NOUN
admet-387	149	9	and	and	CCONJ
admet-387	149	10	humans	human	NOUN
admet-387	149	11	are	be	AUX
admet-387	149	12	left	leave	VERB
admet-387	149	13	with	with	ADP
admet-387	149	14	a	a	DET
admet-387	149	15	uric	uric	ADJ
admet-387	149	16	acid	acid	NOUN
admet-387	149	17	load	load	NOUN
admet-387	149	18	that	that	PRON
admet-387	149	19	in	in	ADP
admet-387	149	20	a	a	DET
admet-387	149	21	time	time	NOUN
admet-387	149	22	of	of	ADP
admet-387	149	23	resource	resource	NOUN
admet-387	149	24	excess	excess	NOUN
admet-387	149	25	has	have	AUX
admet-387	149	26	created	create	VERB
admet-387	149	27	an	an	DET
admet-387	149	28	epidemic	epidemic	NOUN
admet-387	149	29	of	of	ADP
admet-387	149	30	gout	gout	NOUN
admet-387	149	31	and	and	CCONJ
admet-387	149	32	potentially	potentially	ADV
admet-387	149	33	other	other	ADJ
admet-387	149	34	comorbidities	comorbiditie	NOUN
admet-387	149	35	associated	associate	VERB
admet-387	149	36	with	with	ADP
admet-387	149	37	uric	uric	ADJ
admet-387	149	38	acid	acid	NOUN
admet-387	150	1	[	[	X
admet-387	150	2	51	51	NUM
admet-387	150	3	]	]	PUNCT
admet-387	150	4	.	.	PUNCT
admet-387	151	1	despite	despite	SCONJ
admet-387	151	2	the	the	DET
admet-387	151	3	strength	strength	NOUN
admet-387	151	4	of	of	ADP
admet-387	151	5	the	the	DET
admet-387	151	6	association	association	NOUN
admet-387	151	7	between	between	ADP
admet-387	151	8	uric	uric	ADJ
admet-387	151	9	acid	acid	NOUN
admet-387	151	10	and	and	CCONJ
admet-387	151	11	cardiovascular	cardiovascular	ADJ
admet-387	151	12	disease	disease	NOUN
admet-387	151	13	,	,	PUNCT
admet-387	151	14	hypertension	hypertension	NOUN
admet-387	151	15	and	and	CCONJ
admet-387	151	16	chronic	chronic	ADJ
admet-387	151	17	kidney	kidney	NOUN
admet-387	151	18	disease	disease	NOUN
admet-387	151	19	,	,	PUNCT
admet-387	151	20	these	these	DET
admet-387	151	21	studies	study	NOUN
admet-387	151	22	do	do	AUX
admet-387	151	23	not	not	PART
admet-387	151	24	provide	provide	VERB
admet-387	151	25	causation	causation	NOUN
admet-387	151	26	,	,	PUNCT
admet-387	151	27	thus	thus	ADV
admet-387	151	28	it	it	PRON
admet-387	151	29	is	be	AUX
admet-387	151	30	unclear	unclear	ADJ
admet-387	151	31	if	if	SCONJ
admet-387	151	32	uric	uric	ADJ
admet-387	151	33	acid	acid	NOUN
admet-387	151	34	levels	level	NOUN
admet-387	151	35	are	be	AUX
admet-387	151	36	the	the	DET
admet-387	151	37	culprit	culprit	NOUN
admet-387	151	38	in	in	ADP
admet-387	151	39	driving	drive	VERB
admet-387	151	40	these	these	DET
admet-387	151	41	illnesses	illness	NOUN
admet-387	151	42	.	.	PUNCT
admet-387	152	1	more	more	ADJ
admet-387	152	2	recent	recent	ADJ
admet-387	152	3	studies	study	NOUN
admet-387	152	4	utilizing	utilize	VERB
admet-387	152	5	mendelian	mendelian	ADJ
admet-387	152	6	randomization	randomization	NOUN
admet-387	152	7	and	and	CCONJ
admet-387	152	8	interventional	interventional	ADJ
admet-387	152	9	urate	urate	NOUN
admet-387	152	10	lowering	lower	VERB
admet-387	152	11	drugs	drug	NOUN
admet-387	152	12	have	have	AUX
admet-387	152	13	suggested	suggest	VERB
admet-387	152	14	that	that	SCONJ
admet-387	152	15	some	some	DET
admet-387	152	16	aspects	aspect	NOUN
admet-387	152	17	of	of	ADP
admet-387	152	18	the	the	DET
admet-387	152	19	comorbidities	comorbiditie	NOUN
admet-387	152	20	are	be	AUX
admet-387	152	21	not	not	PART
admet-387	152	22	caused	cause	VERB
admet-387	152	23	by	by	ADP
admet-387	152	24	uric	uric	ADJ
admet-387	152	25	acid	acid	NOUN
admet-387	153	1	[	[	X
admet-387	153	2	52	52	NUM
admet-387	153	3	,	,	PUNCT
admet-387	153	4	53	53	NUM
admet-387	153	5	]	]	PUNCT
admet-387	153	6	and	and	CCONJ
admet-387	153	7	others	other	NOUN
admet-387	153	8	indicate	indicate	VERB
admet-387	153	9	that	that	SCONJ
admet-387	153	10	uric	uric	ADJ
admet-387	153	11	acid	acid	NOUN
admet-387	153	12	is	be	AUX
admet-387	153	13	causing	cause	VERB
admet-387	153	14	these	these	DET
admet-387	153	15	comorbidities	comorbiditie	NOUN
admet-387	153	16	[	[	X
admet-387	153	17	54	54	NUM
admet-387	153	18	,	,	PUNCT
admet-387	153	19	55	55	NUM
admet-387	153	20	]	]	PUNCT
admet-387	153	21	.	.	PUNCT
admet-387	154	1	the	the	DET
admet-387	154	2	data	datum	NOUN
admet-387	154	3	for	for	ADP
admet-387	154	4	these	these	DET
admet-387	154	5	findings	finding	NOUN
admet-387	154	6	is	be	AUX
admet-387	154	7	actively	actively	ADV
admet-387	154	8	being	be	AUX
admet-387	154	9	developed	develop	VERB
admet-387	154	10	thus	thus	ADV
admet-387	154	11	the	the	DET
admet-387	154	12	overall	overall	ADJ
admet-387	154	13	picture	picture	NOUN
admet-387	154	14	will	will	AUX
admet-387	154	15	certainly	certainly	ADV
admet-387	154	16	change	change	VERB
admet-387	154	17	in	in	ADP
admet-387	154	18	the	the	DET
admet-387	154	19	coming	come	VERB
admet-387	154	20	years	year	NOUN
admet-387	154	21	.	.	PUNCT
admet-387	155	1	this	this	PRON
admet-387	155	2	is	be	AUX
admet-387	155	3	important	important	ADJ
admet-387	155	4	because	because	SCONJ
admet-387	155	5	if	if	SCONJ
admet-387	155	6	uric	uric	ADJ
admet-387	155	7	acid	acid	NOUN
admet-387	155	8	is	be	AUX
admet-387	155	9	participating	participate	VERB
admet-387	155	10	in	in	ADP
admet-387	155	11	these	these	DET
admet-387	155	12	comorbidities	comorbiditie	NOUN
admet-387	155	13	,	,	PUNCT
admet-387	155	14	then	then	ADV
admet-387	155	15	urate	urate	NOUN
admet-387	155	16	lowering	lower	VERB
admet-387	155	17	therapy	therapy	NOUN
admet-387	155	18	could	could	AUX
admet-387	155	19	well	well	ADV
admet-387	155	20	be	be	AUX
admet-387	155	21	an	an	DET
admet-387	155	22	important	important	ADJ
admet-387	155	23	additional	additional	ADJ
admet-387	155	24	treatment	treatment	NOUN
admet-387	155	25	for	for	ADP
admet-387	155	26	vascular	vascular	ADJ
admet-387	155	27	disease	disease	NOUN
admet-387	155	28	,	,	PUNCT
admet-387	155	29	which	which	PRON
admet-387	155	30	could	could	AUX
admet-387	155	31	work	work	VERB
admet-387	155	32	in	in	ADP
admet-387	155	33	addition	addition	NOUN
admet-387	155	34	to	to	ADP
admet-387	155	35	current	current	ADJ
admet-387	155	36	therapies	therapy	NOUN
admet-387	155	37	.	.	PUNCT
admet-387	156	1	in	in	ADP
admet-387	156	2	humans	human	NOUN
admet-387	156	3	,	,	PUNCT
admet-387	156	4	uric	uric	ADJ
admet-387	156	5	acid	acid	NOUN
admet-387	156	6	is	be	AUX
admet-387	156	7	produced	produce	VERB
admet-387	156	8	by	by	ADP
admet-387	156	9	the	the	DET
admet-387	156	10	degradation	degradation	NOUN
admet-387	156	11	of	of	ADP
admet-387	156	12	endogenous	endogenous	ADJ
admet-387	156	13	purines	purine	NOUN
admet-387	156	14	and	and	CCONJ
admet-387	156	15	the	the	DET
admet-387	156	16	purines	purine	NOUN
admet-387	156	17	in	in	ADP
admet-387	156	18	food	food	NOUN
admet-387	156	19	.	.	PUNCT
admet-387	157	1	there	there	PRON
admet-387	157	2	are	be	VERB
admet-387	157	3	three	three	NUM
admet-387	157	4	primary	primary	ADJ
admet-387	157	5	sources	source	NOUN
admet-387	157	6	of	of	ADP
admet-387	157	7	uric	uric	ADJ
admet-387	157	8	acid	acid	NOUN
admet-387	157	9	in	in	ADP
admet-387	157	10	the	the	DET
admet-387	157	11	body	body	NOUN
admet-387	157	12	:	:	PUNCT
admet-387	157	13	1	1	X
admet-387	157	14	)	)	PUNCT
admet-387	157	15	metabolism	metabolism	NOUN
admet-387	157	16	,	,	PUNCT
admet-387	157	17	whereby	whereby	SCONJ
admet-387	157	18	free	free	ADJ
admet-387	157	19	circulating	circulate	VERB
admet-387	157	20	purines	purine	NOUN
admet-387	157	21	are	be	AUX
admet-387	157	22	degraded	degrade	VERB
admet-387	157	23	in	in	ADP
admet-387	157	24	the	the	DET
admet-387	157	25	liver	liver	NOUN
admet-387	157	26	and	and	CCONJ
admet-387	157	27	intestines	intestine	NOUN
admet-387	157	28	by	by	ADP
admet-387	157	29	xanthine	xanthine	NOUN
admet-387	157	30	oxidase	oxidase	NOUN
admet-387	157	31	into	into	ADP
admet-387	157	32	uric	uric	ADJ
admet-387	157	33	acid	acid	NOUN
admet-387	157	34	,	,	PUNCT
admet-387	157	35	2	2	NUM
admet-387	157	36	)	)	PUNCT
admet-387	157	37	ongoing	ongoing	ADJ
admet-387	157	38	cellular	cellular	ADJ
admet-387	157	39	degradation	degradation	NOUN
admet-387	157	40	(	(	PUNCT
admet-387	157	41	releasing	release	VERB
admet-387	157	42	dna	dna	NOUN
admet-387	157	43	and	and	CCONJ
admet-387	157	44	rna	rna	PROPN
admet-387	157	45	)	)	PUNCT
admet-387	157	46	,	,	PUNCT
admet-387	157	47	which	which	PRON
admet-387	157	48	are	be	AUX
admet-387	157	49	degraded	degrade	VERB
admet-387	157	50	into	into	ADP
admet-387	157	51	uric	uric	ADJ
admet-387	157	52	acid	acid	NOUN
admet-387	157	53	,	,	PUNCT
admet-387	157	54	and	and	CCONJ
admet-387	157	55	3	3	X
admet-387	157	56	)	)	PUNCT
admet-387	157	57	diet	diet	NOUN
admet-387	157	58	has	have	VERB
admet-387	157	59	a	a	DET
admet-387	157	60	smaller	small	ADJ
admet-387	157	61	impact	impact	NOUN
admet-387	157	62	through	through	ADP
admet-387	157	63	the	the	DET
admet-387	157	64	ingestion	ingestion	NOUN
admet-387	157	65	of	of	ADP
admet-387	157	66	purines	purine	NOUN
admet-387	157	67	and	and	CCONJ
admet-387	157	68	nucleic	nucleic	ADJ
admet-387	157	69	acids	acid	NOUN
admet-387	157	70	and	and	CCONJ
admet-387	157	71	subsequent	subsequent	ADJ
admet-387	157	72	metabolism	metabolism	NOUN
admet-387	157	73	of	of	ADP
admet-387	157	74	these	these	DET
admet-387	157	75	compounds	compound	NOUN
admet-387	157	76	in	in	ADP
admet-387	157	77	the	the	DET
admet-387	157	78	intestinal	intestinal	ADJ
admet-387	157	79	mucosa	mucosa	NOUN
admet-387	157	80	by	by	ADP
admet-387	157	81	resident	resident	ADJ
admet-387	157	82	xanthine	xanthine	NOUN
admet-387	157	83	oxidase	oxidase	PROPN
admet-387	157	84	.	.	PUNCT
admet-387	158	1	the	the	DET
admet-387	158	2	effects	effect	NOUN
admet-387	158	3	of	of	ADP
admet-387	158	4	dietary	dietary	ADJ
admet-387	158	5	purines	purine	NOUN
admet-387	158	6	on	on	ADP
admet-387	158	7	serum	serum	NOUN
admet-387	158	8	uric	uric	ADJ
admet-387	158	9	acid	acid	NOUN
admet-387	158	10	levels	level	NOUN
admet-387	158	11	is	be	AUX
admet-387	158	12	relatively	relatively	ADV
admet-387	158	13	mild	mild	ADJ
admet-387	158	14	with	with	ADP
admet-387	158	15	even	even	ADV
admet-387	158	16	strict	strict	ADJ
admet-387	158	17	diets	diet	NOUN
admet-387	158	18	affecting	affect	VERB
admet-387	158	19	uric	uric	ADJ
admet-387	158	20	acid	acid	NOUN
admet-387	158	21	levels	level	NOUN
admet-387	158	22	marginally	marginally	ADV
admet-387	158	23	[	[	X
admet-387	158	24	56	56	NUM
admet-387	158	25	]	]	PUNCT
admet-387	158	26	.	.	PUNCT
admet-387	159	1	purine	purine	NOUN
admet-387	159	2	increases	increase	NOUN
admet-387	159	3	from	from	ADP
admet-387	159	4	resulting	result	VERB
admet-387	159	5	from	from	ADP
admet-387	159	6	fructose	fructose	NOUN
admet-387	159	7	,	,	PUNCT
admet-387	159	8	beer	beer	NOUN
admet-387	159	9	(	(	PUNCT
admet-387	159	10	from	from	ADP
admet-387	159	11	yeast	yeast	NOUN
admet-387	159	12	)	)	PUNCT
admet-387	159	13	and	and	CCONJ
admet-387	159	14	other	other	ADJ
admet-387	159	15	purine	purine	NOUN
admet-387	159	16	rich	rich	ADJ
admet-387	159	17	foods	food	NOUN
admet-387	159	18	is	be	AUX
admet-387	159	19	of	of	ADP
admet-387	159	20	primary	primary	ADJ
admet-387	159	21	concern	concern	NOUN
admet-387	159	22	.	.	PUNCT
admet-387	160	1	fructose	fructose	ADJ
admet-387	160	2	ingestion	ingestion	NOUN
admet-387	160	3	depletes	deplete	VERB
admet-387	160	4	atp	atp	NOUN
admet-387	160	5	from	from	ADP
admet-387	160	6	the	the	DET
admet-387	160	7	action	action	NOUN
admet-387	160	8	of	of	ADP
admet-387	160	9	fructokinase	fructokinase	NOUN
admet-387	160	10	.	.	PUNCT
admet-387	161	1	the	the	DET
admet-387	161	2	depleted	deplete	VERB
admet-387	161	3	atp	atp	PROPN
admet-387	161	4	(	(	PUNCT
admet-387	161	5	amp	amp	PROPN
admet-387	161	6	)	)	PUNCT
admet-387	161	7	is	be	AUX
admet-387	161	8	converted	convert	VERB
admet-387	161	9	to	to	ADP
admet-387	161	10	uric	uric	ADJ
admet-387	161	11	acid	acid	NOUN
admet-387	161	12	through	through	ADP
admet-387	161	13	the	the	DET
admet-387	161	14	purine	purine	NOUN
admet-387	161	15	catabolic	catabolic	ADJ
admet-387	161	16	pathway	pathway	NOUN
admet-387	161	17	.	.	PUNCT
admet-387	162	1	once	once	ADV
admet-387	162	2	produced	produce	VERB
admet-387	162	3	,	,	PUNCT
admet-387	162	4	urate	urate	NOUN
admet-387	162	5	can	can	AUX
admet-387	162	6	not	not	PART
admet-387	162	7	be	be	AUX
admet-387	162	8	degraded	degrade	VERB
admet-387	162	9	by	by	ADP
admet-387	162	10	the	the	DET
admet-387	162	11	human	human	ADJ
admet-387	162	12	body	body	NOUN
admet-387	162	13	so	so	SCONJ
admet-387	162	14	all	all	DET
admet-387	162	15	urate	urate	NOUN
admet-387	162	16	must	must	AUX
admet-387	162	17	be	be	AUX
admet-387	162	18	eliminated	eliminate	VERB
admet-387	162	19	either	either	CCONJ
admet-387	162	20	by	by	ADP
admet-387	162	21	the	the	DET
admet-387	162	22	kidney	kidney	NOUN
admet-387	162	23	or	or	CCONJ
admet-387	162	24	the	the	DET
admet-387	162	25	intestine	intestine	NOUN
admet-387	162	26	.	.	PUNCT
admet-387	163	1	two	two	NUM
admet-387	163	2	-	-	PUNCT
admet-387	163	3	thirds	third	NOUN
admet-387	163	4	of	of	ADP
admet-387	163	5	urate	urate	NOUN
admet-387	163	6	elimination	elimination	NOUN
admet-387	163	7	is	be	AUX
admet-387	163	8	through	through	ADP
admet-387	163	9	the	the	DET
admet-387	163	10	kidneys	kidney	NOUN
admet-387	163	11	,	,	PUNCT
admet-387	163	12	the	the	DET
admet-387	163	13	remainder	remainder	NOUN
admet-387	163	14	through	through	ADP
admet-387	163	15	the	the	DET
admet-387	163	16	intestines	intestine	NOUN
admet-387	163	17	.	.	PUNCT
admet-387	164	1	the	the	DET
admet-387	164	2	balance	balance	NOUN
admet-387	164	3	of	of	ADP
admet-387	164	4	production	production	NOUN
admet-387	164	5	and	and	CCONJ
admet-387	164	6	elimination	elimination	NOUN
admet-387	164	7	determines	determine	VERB
admet-387	164	8	the	the	DET
admet-387	164	9	concentration	concentration	NOUN
admet-387	164	10	of	of	ADP
admet-387	164	11	uric	uric	ADJ
admet-387	164	12	acid	acid	NOUN
admet-387	164	13	in	in	ADP
admet-387	164	14	the	the	DET
admet-387	164	15	serum	serum	NOUN
admet-387	164	16	as	as	SCONJ
admet-387	164	17	described	describe	VERB
admet-387	164	18	above	above	ADV
admet-387	164	19	.	.	PUNCT
admet-387	165	1	genetics	genetic	NOUN
admet-387	165	2	of	of	ADP
admet-387	165	3	uric	uric	ADJ
admet-387	165	4	acid	acid	NOUN
admet-387	165	5	genome	genome	NOUN
admet-387	165	6	-	-	PUNCT
admet-387	165	7	wide	wide	ADJ
admet-387	165	8	association	association	NOUN
admet-387	165	9	studies	study	NOUN
admet-387	165	10	(	(	PUNCT
admet-387	165	11	gwas	gwas	PROPN
admet-387	165	12	)	)	PUNCT
admet-387	165	13	have	have	AUX
admet-387	165	14	identified	identify	VERB
admet-387	165	15	28	28	NUM
admet-387	165	16	separate	separate	ADJ
admet-387	165	17	loci	locus	NOUN
admet-387	165	18	that	that	PRON
admet-387	165	19	control	control	VERB
admet-387	165	20	hyperuricemia	hyperuricemia	NOUN
admet-387	165	21	and	and	CCONJ
admet-387	165	22	gout	gout	NOUN
admet-387	165	23	.	.	PUNCT
admet-387	166	1	many	many	ADJ
admet-387	166	2	of	of	ADP
admet-387	166	3	these	these	DET
admet-387	166	4	code	code	NOUN
admet-387	166	5	for	for	ADP
admet-387	166	6	transporters	transporter	NOUN
admet-387	166	7	directly	directly	ADV
admet-387	166	8	involved	involve	VERB
admet-387	166	9	in	in	ADP
admet-387	166	10	the	the	DET
admet-387	166	11	regulation	regulation	NOUN
admet-387	166	12	of	of	ADP
admet-387	166	13	uric	uric	ADJ
admet-387	166	14	acid	acid	NOUN
admet-387	166	15	levels	level	NOUN
admet-387	166	16	in	in	ADP
admet-387	166	17	humans	human	NOUN
admet-387	166	18	.	.	PUNCT
admet-387	167	1	these	these	PRON
admet-387	167	2	include	include	VERB
admet-387	167	3	transporters	transporter	NOUN
admet-387	167	4	found	find	VERB
admet-387	167	5	in	in	ADP
admet-387	167	6	the	the	DET
admet-387	167	7	kidney	kidney	NOUN
admet-387	167	8	,	,	PUNCT
admet-387	167	9	liver	liver	NOUN
admet-387	167	10	and	and	CCONJ
admet-387	167	11	intestine	intestine	VERB
admet-387	167	12	with	with	ADP
admet-387	167	13	functions	function	NOUN
admet-387	167	14	spanning	span	VERB
admet-387	167	15	both	both	CCONJ
admet-387	167	16	uric	uric	ADJ
admet-387	167	17	acid	acid	NOUN
admet-387	167	18	secretion	secretion	NOUN
admet-387	167	19	and	and	CCONJ
admet-387	167	20	resorption	resorption	NOUN
admet-387	167	21	[	[	X
admet-387	167	22	57	57	NUM
admet-387	167	23	]	]	PUNCT
admet-387	167	24	.	.	PUNCT
admet-387	168	1	gwas	gwas	PROPN
admet-387	168	2	studies	study	NOUN
admet-387	168	3	also	also	ADV
admet-387	168	4	show	show	VERB
admet-387	168	5	influence	influence	NOUN
admet-387	168	6	of	of	ADP
admet-387	168	7	urate	urate	NOUN
admet-387	168	8	production	production	NOUN
admet-387	168	9	(	(	PUNCT
admet-387	168	10	glucokinase	glucokinase	NOUN
admet-387	168	11	regulator	regulator	NOUN
admet-387	168	12	or	or	CCONJ
admet-387	168	13	gckr	gckr	NOUN
admet-387	168	14	,	,	PUNCT
admet-387	168	15	inhibin	inhibin	ADJ
admet-387	168	16	-	-	PUNCT
admet-387	168	17	activin	activin	NOUN
admet-387	168	18	network	network	NOUN
admet-387	168	19	,	,	PUNCT
admet-387	168	20	insulin	insulin	NOUN
admet-387	168	21	)	)	PUNCT
admet-387	168	22	–	–	PUNCT
admet-387	168	23	links	link	NOUN
admet-387	168	24	to	to	PART
admet-387	168	25	glucose	glucose	NOUN
admet-387	168	26	homeostasis	homeostasis	NOUN
admet-387	168	27	,	,	PUNCT
admet-387	168	28	diabetes	diabetes	NOUN
admet-387	168	29	,	,	PUNCT
admet-387	168	30	feeding	feed	VERB
admet-387	168	31	status	status	NOUN
admet-387	168	32	,	,	PUNCT
admet-387	168	33	energy	energy	NOUN
admet-387	168	34	expenditure	expenditure	NOUN
admet-387	168	35	.	.	PUNCT
admet-387	169	1	admet	admet	PROPN
admet-387	169	2	&	&	CCONJ
admet-387	169	3	dmpk	dmpk	PROPN
admet-387	169	4	5(2	5(2	NUM
admet-387	169	5	)	)	PUNCT
admet-387	169	6	(	(	PUNCT
admet-387	169	7	2017	2017	NUM
admet-387	169	8	)	)	PUNCT
admet-387	169	9	59	59	NUM
admet-387	169	10	-	-	SYM
admet-387	169	11	74	74	NUM
admet-387	169	12	uric	uric	ADJ
admet-387	169	13	acid	acid	NOUN
admet-387	169	14	transporter	transporter	NOUN
admet-387	169	15	inhibitors	inhibitor	NOUN
admet-387	169	16	for	for	ADP
admet-387	169	17	gout	gout	NOUN
admet-387	169	18	doi	doi	NOUN
admet-387	169	19	:	:	PUNCT
admet-387	169	20	10.5599	10.5599	NUM
admet-387	169	21	/	/	SYM
admet-387	169	22	admet.5.1.387	admet.5.1.387	NUM
admet-387	169	23	67	67	NUM
admet-387	169	24	interestingly	interestingly	ADV
admet-387	169	25	,	,	PUNCT
admet-387	169	26	xanthine	xanthine	NOUN
admet-387	169	27	oxidase	oxidase	NOUN
admet-387	169	28	,	,	PUNCT
admet-387	169	29	and	and	CCONJ
admet-387	169	30	other	other	ADJ
admet-387	169	31	enzymes	enzyme	NOUN
admet-387	169	32	in	in	ADP
admet-387	169	33	the	the	DET
admet-387	169	34	uric	uric	ADJ
admet-387	169	35	acid	acid	NOUN
admet-387	169	36	biosynthetic	biosynthetic	ADJ
admet-387	169	37	pathway	pathway	NOUN
admet-387	169	38	are	be	AUX
admet-387	169	39	not	not	PART
admet-387	169	40	found	find	VERB
admet-387	169	41	in	in	ADP
admet-387	169	42	gwas	gwas	PROPN
admet-387	169	43	studies	study	NOUN
admet-387	169	44	suggesting	suggest	VERB
admet-387	169	45	that	that	SCONJ
admet-387	169	46	despite	despite	SCONJ
admet-387	169	47	a	a	DET
admet-387	169	48	clear	clear	ADJ
admet-387	169	49	role	role	NOUN
admet-387	169	50	,	,	PUNCT
admet-387	169	51	apparently	apparently	ADV
admet-387	169	52	genetically	genetically	ADV
admet-387	169	53	available	available	ADJ
admet-387	169	54	variations	variation	NOUN
admet-387	169	55	in	in	ADP
admet-387	169	56	the	the	DET
admet-387	169	57	activity	activity	NOUN
admet-387	169	58	of	of	ADP
admet-387	169	59	these	these	DET
admet-387	169	60	enzymes	enzyme	NOUN
admet-387	169	61	does	do	AUX
admet-387	169	62	not	not	PART
admet-387	169	63	lead	lead	VERB
admet-387	169	64	to	to	ADP
admet-387	169	65	alterations	alteration	NOUN
admet-387	169	66	in	in	ADP
admet-387	169	67	uric	uric	ADJ
admet-387	169	68	acid	acid	NOUN
admet-387	169	69	levels	level	NOUN
admet-387	169	70	.	.	PUNCT
admet-387	170	1	the	the	DET
admet-387	170	2	work	work	NOUN
admet-387	170	3	in	in	ADP
admet-387	170	4	this	this	DET
admet-387	170	5	area	area	NOUN
admet-387	170	6	is	be	AUX
admet-387	170	7	proceeding	proceed	VERB
admet-387	170	8	rapidly	rapidly	ADV
admet-387	170	9	with	with	ADP
admet-387	170	10	ongoing	ongoing	ADJ
admet-387	170	11	resequencing	resequencing	NOUN
admet-387	170	12	projects	project	NOUN
admet-387	170	13	and	and	CCONJ
admet-387	170	14	expression	expression	NOUN
admet-387	170	15	analysis	analysis	NOUN
admet-387	170	16	in	in	ADP
admet-387	170	17	clinical	clinical	ADJ
admet-387	170	18	samples	sample	NOUN
admet-387	170	19	.	.	PUNCT
admet-387	171	1	renal	renal	ADJ
admet-387	171	2	handling	handling	NOUN
admet-387	171	3	of	of	ADP
admet-387	171	4	uric	uric	ADJ
admet-387	171	5	acid	acid	NOUN
admet-387	171	6	in	in	ADP
admet-387	171	7	early	early	ADJ
admet-387	171	8	studies	study	NOUN
admet-387	171	9	on	on	ADP
admet-387	171	10	renal	renal	ADJ
admet-387	171	11	apical	apical	ADJ
admet-387	171	12	bbmvs	bbmvs	NOUN
admet-387	171	13	(	(	PUNCT
admet-387	171	14	brush	brush	NOUN
admet-387	171	15	-	-	PUNCT
admet-387	171	16	border	border	NOUN
admet-387	171	17	membrane	membrane	NOUN
admet-387	171	18	vesicles	vesicle	NOUN
admet-387	171	19	)	)	PUNCT
admet-387	171	20	and	and	CCONJ
admet-387	171	21	basolateral	basolateral	ADJ
admet-387	171	22	vesicles	vesicle	NOUN
admet-387	171	23	,	,	PUNCT
admet-387	171	24	transport	transport	NOUN
admet-387	171	25	activities	activity	NOUN
admet-387	171	26	were	be	AUX
admet-387	171	27	characterized	characterize	VERB
admet-387	171	28	[	[	X
admet-387	171	29	58	58	NUM
admet-387	171	30	]	]	PUNCT
admet-387	171	31	and	and	CCONJ
admet-387	171	32	eventually	eventually	ADV
admet-387	171	33	led	lead	VERB
admet-387	171	34	to	to	ADP
admet-387	171	35	the	the	DET
admet-387	171	36	cloning	cloning	NOUN
admet-387	171	37	of	of	ADP
admet-387	171	38	uric	uric	ADJ
admet-387	171	39	acid	acid	NOUN
admet-387	171	40	transporters	transporter	NOUN
admet-387	171	41	from	from	ADP
admet-387	171	42	renal	renal	ADJ
admet-387	171	43	tissue	tissue	NOUN
admet-387	171	44	and	and	CCONJ
admet-387	171	45	the	the	DET
admet-387	171	46	discovery	discovery	NOUN
admet-387	171	47	of	of	ADP
admet-387	171	48	a	a	DET
admet-387	171	49	multiprotein	multiprotein	ADJ
admet-387	171	50	transportasome	transportasome	NOUN
admet-387	171	51	functioning	function	VERB
admet-387	171	52	to	to	PART
admet-387	171	53	regulate	regulate	VERB
admet-387	171	54	uric	uric	ADJ
admet-387	171	55	acid	acid	NOUN
admet-387	171	56	levels	level	NOUN
admet-387	171	57	at	at	ADP
admet-387	171	58	the	the	DET
admet-387	171	59	apical	apical	ADJ
admet-387	171	60	membrane	membrane	NOUN
admet-387	171	61	[	[	X
admet-387	171	62	59	59	NUM
admet-387	171	63	,	,	PUNCT
admet-387	171	64	60	60	NUM
admet-387	171	65	]	]	PUNCT
admet-387	171	66	.	.	PUNCT
admet-387	172	1	in	in	ADP
admet-387	172	2	a	a	DET
admet-387	172	3	normal	normal	ADJ
admet-387	172	4	human	human	ADJ
admet-387	172	5	kidney	kidney	NOUN
admet-387	172	6	,	,	PUNCT
admet-387	172	7	clearance	clearance	NOUN
admet-387	172	8	of	of	ADP
admet-387	172	9	urate	urate	NOUN
admet-387	172	10	is	be	AUX
admet-387	172	11	a	a	DET
admet-387	172	12	function	function	NOUN
admet-387	172	13	of	of	ADP
admet-387	172	14	glomerular	glomerular	ADJ
admet-387	172	15	filtration	filtration	NOUN
admet-387	172	16	rate	rate	NOUN
admet-387	172	17	(	(	PUNCT
admet-387	172	18	gfr	gfr	NOUN
admet-387	172	19	)	)	PUNCT
admet-387	172	20	and	and	CCONJ
admet-387	172	21	fractional	fractional	ADJ
admet-387	172	22	excretion	excretion	NOUN
admet-387	172	23	of	of	ADP
admet-387	172	24	uric	uric	ADJ
admet-387	172	25	acid	acid	NOUN
admet-387	172	26	.	.	PUNCT
admet-387	173	1	urate	urate	NOUN
admet-387	173	2	is	be	AUX
admet-387	173	3	freely	freely	ADV
admet-387	173	4	filtered	filter	VERB
admet-387	173	5	at	at	ADP
admet-387	173	6	the	the	DET
admet-387	173	7	glomerulus	glomerulus	NOUN
admet-387	173	8	and	and	CCONJ
admet-387	173	9	is	be	AUX
admet-387	173	10	subsequently	subsequently	ADV
admet-387	173	11	almost	almost	ADV
admet-387	173	12	entirely	entirely	ADV
admet-387	173	13	reabsorbed	reabsorb	VERB
admet-387	173	14	within	within	ADP
admet-387	173	15	the	the	DET
admet-387	173	16	proximal	proximal	ADJ
admet-387	173	17	tubule	tubule	NOUN
admet-387	173	18	.	.	PUNCT
admet-387	174	1	secretion	secretion	NOUN
admet-387	174	2	of	of	ADP
admet-387	174	3	urate	urate	NOUN
admet-387	174	4	also	also	ADV
admet-387	174	5	occurs	occur	VERB
admet-387	174	6	,	,	PUNCT
admet-387	174	7	either	either	CCONJ
admet-387	174	8	concomitantly	concomitantly	ADV
admet-387	174	9	with	with	ADP
admet-387	174	10	reabsorption	reabsorption	NOUN
admet-387	174	11	or	or	CCONJ
admet-387	174	12	subsequent	subsequent	ADJ
admet-387	174	13	to	to	ADP
admet-387	174	14	reabsorption	reabsorption	NOUN
admet-387	174	15	.	.	PUNCT
admet-387	175	1	the	the	DET
admet-387	175	2	rate	rate	NOUN
admet-387	175	3	of	of	ADP
admet-387	175	4	urate	urate	NOUN
admet-387	175	5	excretion	excretion	NOUN
admet-387	175	6	as	as	ADP
admet-387	175	7	a	a	DET
admet-387	175	8	percentage	percentage	NOUN
admet-387	175	9	of	of	ADP
admet-387	175	10	the	the	DET
admet-387	175	11	rate	rate	NOUN
admet-387	175	12	of	of	ADP
admet-387	175	13	filtration	filtration	NOUN
admet-387	175	14	of	of	ADP
admet-387	175	15	urate	urate	NOUN
admet-387	175	16	is	be	AUX
admet-387	175	17	termed	term	VERB
admet-387	175	18	the	the	DET
admet-387	175	19	fractional	fractional	ADJ
admet-387	175	20	excretion	excretion	NOUN
admet-387	175	21	of	of	ADP
admet-387	175	22	uric	uric	ADJ
admet-387	175	23	acid	acid	NOUN
admet-387	175	24	(	(	PUNCT
admet-387	175	25	feua	feua	PROPN
admet-387	175	26	)	)	PUNCT
admet-387	175	27	.	.	PUNCT
admet-387	176	1	low	low	PROPN
admet-387	176	2	feua	feua	PROPN
admet-387	176	3	correlates	correlate	VERB
admet-387	176	4	with	with	ADP
admet-387	176	5	increased	increase	VERB
admet-387	176	6	sua	sua	NOUN
admet-387	176	7	and	and	CCONJ
admet-387	176	8	the	the	DET
admet-387	176	9	characterization	characterization	NOUN
admet-387	176	10	of	of	ADP
admet-387	176	11	the	the	DET
admet-387	176	12	efficiency	efficiency	NOUN
admet-387	176	13	of	of	ADP
admet-387	176	14	urate	urate	NOUN
admet-387	176	15	secretion	secretion	NOUN
admet-387	176	16	is	be	AUX
admet-387	176	17	typically	typically	ADV
admet-387	176	18	done	do	VERB
admet-387	176	19	by	by	ADP
admet-387	176	20	measuring	measure	VERB
admet-387	176	21	feua	feua	PROPN
admet-387	176	22	.	.	PUNCT
admet-387	177	1	gout	gout	NOUN
admet-387	177	2	patients	patient	NOUN
admet-387	177	3	often	often	ADV
admet-387	177	4	exhibit	exhibit	AUX
admet-387	177	5	significantly	significantly	ADV
admet-387	177	6	decreased	decrease	VERB
admet-387	177	7	feua	feua	PROPN
admet-387	177	8	.	.	PUNCT
admet-387	178	1	in	in	ADP
admet-387	178	2	addition	addition	NOUN
admet-387	178	3	,	,	PUNCT
admet-387	178	4	decreased	decrease	VERB
admet-387	178	5	gfr	gfr	NOUN
admet-387	178	6	also	also	ADV
admet-387	178	7	increases	increase	VERB
admet-387	178	8	sua	sua	ADJ
admet-387	178	9	,	,	PUNCT
admet-387	178	10	so	so	SCONJ
admet-387	178	11	patients	patient	NOUN
admet-387	178	12	with	with	ADP
admet-387	178	13	low	low	ADJ
admet-387	178	14	feua	feua	PROPN
admet-387	178	15	,	,	PUNCT
admet-387	178	16	or	or	CCONJ
admet-387	178	17	impaired	impair	VERB
admet-387	178	18	renal	renal	ADJ
admet-387	178	19	function	function	NOUN
admet-387	178	20	are	be	AUX
admet-387	178	21	in	in	ADP
admet-387	178	22	danger	danger	NOUN
admet-387	178	23	of	of	ADP
admet-387	178	24	hyperuricemia	hyperuricemia	NOUN
admet-387	178	25	and	and	CCONJ
admet-387	178	26	gout	gout	PROPN
admet-387	178	27	renal	renal	ADJ
admet-387	178	28	uric	uric	ADJ
admet-387	178	29	acid	acid	NOUN
admet-387	178	30	reabsorption	reabsorption	NOUN
admet-387	178	31	most	most	ADV
admet-387	178	32	uric	uric	ADJ
admet-387	178	33	acid	acid	NOUN
admet-387	178	34	that	that	PRON
admet-387	178	35	is	be	AUX
admet-387	178	36	filtered	filter	VERB
admet-387	178	37	by	by	ADP
admet-387	178	38	the	the	DET
admet-387	178	39	glomerulus	glomerulus	NOUN
admet-387	178	40	is	be	AUX
admet-387	178	41	reabsorbed	reabsorb	VERB
admet-387	178	42	in	in	ADP
admet-387	178	43	the	the	DET
admet-387	178	44	proximal	proximal	ADJ
admet-387	178	45	tubule	tubule	NOUN
admet-387	178	46	.	.	PUNCT
admet-387	179	1	the	the	DET
admet-387	179	2	main	main	ADJ
admet-387	179	3	transporter	transporter	NOUN
admet-387	179	4	on	on	ADP
admet-387	179	5	the	the	DET
admet-387	179	6	apical	apical	ADJ
admet-387	179	7	side	side	NOUN
admet-387	179	8	of	of	ADP
admet-387	179	9	the	the	DET
admet-387	179	10	tubule	tubule	NOUN
admet-387	179	11	is	be	AUX
admet-387	179	12	urat1	urat1	NOUN
admet-387	179	13	,	,	PUNCT
admet-387	179	14	however	however	SCONJ
admet-387	179	15	oat4	oat4	PROPN
admet-387	179	16	and	and	CCONJ
admet-387	179	17	oat10	oat10	ADJ
admet-387	179	18	are	be	AUX
admet-387	179	19	also	also	ADV
admet-387	179	20	possible	possible	ADJ
admet-387	179	21	contributors	contributor	NOUN
admet-387	179	22	to	to	ADP
admet-387	179	23	uric	uric	ADJ
admet-387	179	24	acid	acid	NOUN
admet-387	179	25	resorption	resorption	NOUN
admet-387	179	26	across	across	ADP
admet-387	179	27	the	the	DET
admet-387	179	28	apical	apical	ADJ
admet-387	179	29	membrane	membrane	NOUN
admet-387	179	30	.	.	PUNCT
admet-387	180	1	it	it	PRON
admet-387	180	2	is	be	AUX
admet-387	180	3	likely	likely	ADJ
admet-387	180	4	that	that	SCONJ
admet-387	180	5	the	the	DET
admet-387	180	6	sole	sole	ADJ
admet-387	180	7	transporter	transporter	NOUN
admet-387	180	8	on	on	ADP
admet-387	180	9	the	the	DET
admet-387	180	10	basolateral	basolateral	ADJ
admet-387	180	11	side	side	NOUN
admet-387	180	12	is	be	AUX
admet-387	180	13	glut9	glut9	NOUN
admet-387	180	14	.	.	PUNCT
admet-387	181	1	this	this	PRON
admet-387	181	2	is	be	AUX
admet-387	181	3	because	because	SCONJ
admet-387	181	4	the	the	DET
admet-387	181	5	phenotype	phenotype	NOUN
admet-387	181	6	of	of	ADP
admet-387	181	7	glut9	glut9	NOUN
admet-387	181	8	mutations	mutation	NOUN
admet-387	181	9	in	in	ADP
admet-387	181	10	humans	human	NOUN
admet-387	181	11	results	result	VERB
admet-387	181	12	in	in	ADP
admet-387	181	13	an	an	DET
admet-387	181	14	feua	feua	PROPN
admet-387	181	15	at	at	ADP
admet-387	181	16	or	or	CCONJ
admet-387	181	17	above	above	ADP
admet-387	181	18	100	100	NUM
admet-387	181	19	%	%	NOUN
admet-387	181	20	,	,	PUNCT
admet-387	181	21	suggesting	suggest	VERB
admet-387	181	22	complete	complete	ADJ
admet-387	181	23	loss	loss	NOUN
admet-387	181	24	of	of	ADP
admet-387	181	25	resorption	resorption	NOUN
admet-387	181	26	[	[	X
admet-387	181	27	61	61	NUM
admet-387	181	28	]	]	PUNCT
admet-387	181	29	.	.	PUNCT
admet-387	182	1	in	in	ADP
admet-387	182	2	contrast	contrast	NOUN
admet-387	182	3	,	,	PUNCT
admet-387	182	4	the	the	DET
admet-387	182	5	effect	effect	NOUN
admet-387	182	6	of	of	ADP
admet-387	182	7	urat1	urat1	NOUN
admet-387	182	8	mutations	mutation	NOUN
admet-387	182	9	on	on	ADP
admet-387	182	10	feua	feua	PROPN
admet-387	182	11	is	be	AUX
admet-387	182	12	less	less	ADV
admet-387	182	13	severe	severe	ADJ
admet-387	182	14	>	>	ADP
admet-387	182	15	50	50	NUM
admet-387	182	16	%	%	NOUN
admet-387	182	17	[	[	X
admet-387	182	18	62	62	NUM
admet-387	182	19	]	]	PUNCT
admet-387	182	20	.	.	PUNCT
admet-387	183	1	other	other	ADJ
admet-387	183	2	transporters	transporter	NOUN
admet-387	183	3	may	may	AUX
admet-387	183	4	be	be	AUX
admet-387	183	5	present	present	ADJ
admet-387	183	6	on	on	ADP
admet-387	183	7	the	the	DET
admet-387	183	8	apical	apical	ADJ
admet-387	183	9	side	side	NOUN
admet-387	183	10	but	but	CCONJ
admet-387	183	11	it	it	PRON
admet-387	183	12	is	be	AUX
admet-387	183	13	believed	believe	VERB
admet-387	183	14	that	that	SCONJ
admet-387	183	15	only	only	ADV
admet-387	183	16	glut9	glut9	NOUN
admet-387	183	17	functions	function	NOUN
admet-387	183	18	to	to	PART
admet-387	183	19	export	export	VERB
admet-387	183	20	urate	urate	NOUN
admet-387	183	21	to	to	ADP
admet-387	183	22	the	the	DET
admet-387	183	23	interstitium	interstitium	NOUN
admet-387	183	24	(	(	PUNCT
admet-387	183	25	blood	blood	NOUN
admet-387	183	26	side	side	NOUN
admet-387	183	27	)	)	PUNCT
admet-387	183	28	across	across	ADP
admet-387	183	29	the	the	DET
admet-387	183	30	basolateral	basolateral	ADJ
admet-387	183	31	membrane	membrane	NOUN
admet-387	183	32	.	.	PUNCT
admet-387	184	1	the	the	DET
admet-387	184	2	sensitivity	sensitivity	NOUN
admet-387	184	3	of	of	ADP
admet-387	184	4	the	the	DET
admet-387	184	5	kidney	kidney	NOUN
admet-387	184	6	to	to	ADP
admet-387	184	7	alterations	alteration	NOUN
admet-387	184	8	in	in	ADP
admet-387	184	9	transporter	transporter	NOUN
admet-387	184	10	function	function	NOUN
admet-387	184	11	is	be	AUX
admet-387	184	12	also	also	ADV
admet-387	184	13	detected	detect	VERB
admet-387	184	14	at	at	ADP
admet-387	184	15	the	the	DET
admet-387	184	16	level	level	NOUN
admet-387	184	17	of	of	ADP
admet-387	184	18	gene	gene	NOUN
admet-387	184	19	expression	expression	NOUN
admet-387	184	20	of	of	ADP
admet-387	184	21	the	the	DET
admet-387	184	22	transporter	transporter	NOUN
admet-387	184	23	urat1	urat1	NOUN
admet-387	184	24	.	.	PUNCT
admet-387	185	1	in	in	ADP
admet-387	185	2	women	woman	NOUN
admet-387	185	3	,	,	PUNCT
admet-387	185	4	urat1	urat1	NOUN
admet-387	185	5	expression	expression	NOUN
admet-387	185	6	is	be	AUX
admet-387	185	7	likely	likely	ADV
admet-387	185	8	down	down	ADV
admet-387	185	9	regulated	regulate	VERB
admet-387	185	10	by	by	ADP
admet-387	185	11	estrogens	estrogen	NOUN
admet-387	185	12	resulting	result	VERB
admet-387	185	13	in	in	ADP
admet-387	185	14	fewer	few	ADJ
admet-387	185	15	transporters	transporter	NOUN
admet-387	185	16	at	at	ADP
admet-387	185	17	the	the	DET
admet-387	185	18	apical	apical	ADJ
admet-387	185	19	surface	surface	NOUN
admet-387	185	20	and	and	CCONJ
admet-387	185	21	gfr	gfr	NOUN
admet-387	185	22	is	be	AUX
admet-387	185	23	increased	increase	VERB
admet-387	185	24	by	by	ADP
admet-387	185	25	estrogen	estrogen	NOUN
admet-387	185	26	through	through	ADP
admet-387	185	27	renal	renal	ADJ
admet-387	185	28	vasodilation	vasodilation	NOUN
admet-387	185	29	.	.	PUNCT
admet-387	186	1	in	in	ADP
admet-387	186	2	mice	mice	NOUN
admet-387	186	3	,	,	PUNCT
admet-387	186	4	urat1	urat1	NOUN
admet-387	186	5	and	and	CCONJ
admet-387	186	6	glut9	glut9	NOUN
admet-387	186	7	expression	expression	NOUN
admet-387	186	8	is	be	AUX
admet-387	186	9	decreased	decrease	VERB
admet-387	186	10	in	in	ADP
admet-387	186	11	the	the	DET
admet-387	186	12	presence	presence	NOUN
admet-387	186	13	of	of	ADP
admet-387	186	14	estradiol	estradiol	PROPN
admet-387	186	15	consistent	consistent	ADJ
admet-387	186	16	with	with	ADP
admet-387	186	17	premenopausal	premenopausal	NOUN
admet-387	186	18	women	woman	NOUN
admet-387	186	19	having	have	VERB
admet-387	186	20	significantly	significantly	ADV
admet-387	186	21	lower	low	ADJ
admet-387	186	22	uric	uric	ADJ
admet-387	186	23	acid	acid	NOUN
admet-387	186	24	levels	level	NOUN
admet-387	186	25	that	that	PRON
admet-387	186	26	post	post	ADJ
admet-387	186	27	-	-	ADJ
admet-387	186	28	menopausal	menopausal	ADJ
admet-387	186	29	women	woman	NOUN
admet-387	186	30	[	[	X
admet-387	186	31	63	63	NUM
admet-387	186	32	,	,	PUNCT
admet-387	186	33	64	64	NUM
admet-387	186	34	]	]	PUNCT
admet-387	186	35	.	.	PUNCT
admet-387	187	1	further	further	ADJ
admet-387	187	2	confirmation	confirmation	NOUN
admet-387	187	3	of	of	ADP
admet-387	187	4	this	this	DET
admet-387	187	5	effect	effect	NOUN
admet-387	187	6	is	be	AUX
admet-387	187	7	obtained	obtain	VERB
admet-387	187	8	through	through	ADP
admet-387	187	9	testing	testing	NOUN
admet-387	187	10	of	of	ADP
admet-387	187	11	uric	uric	ADJ
admet-387	187	12	acid	acid	NOUN
admet-387	187	13	levels	level	NOUN
admet-387	187	14	in	in	ADP
admet-387	187	15	patients	patient	NOUN
admet-387	187	16	undergoing	undergo	VERB
admet-387	187	17	gender	gender	NOUN
admet-387	187	18	reassignment	reassignment	NOUN
admet-387	187	19	.	.	PUNCT
admet-387	188	1	addition	addition	NOUN
admet-387	188	2	of	of	ADP
admet-387	188	3	estrogen	estrogen	NOUN
admet-387	188	4	lowers	lower	VERB
admet-387	188	5	uric	uric	ADJ
admet-387	188	6	acid	acid	NOUN
admet-387	188	7	levels	level	NOUN
admet-387	188	8	and	and	CCONJ
admet-387	188	9	addition	addition	NOUN
admet-387	188	10	of	of	ADP
admet-387	188	11	androgen	androgen	NOUN
admet-387	188	12	raises	raise	VERB
admet-387	188	13	them	they	PRON
admet-387	188	14	in	in	ADP
admet-387	188	15	these	these	DET
admet-387	188	16	patients	patient	NOUN
admet-387	189	1	[	[	X
admet-387	189	2	65	65	NUM
admet-387	189	3	]	]	PUNCT
admet-387	189	4	.	.	PUNCT
admet-387	190	1	reabsorption	reabsorption	NOUN
admet-387	190	2	transporters	transporter	NOUN
admet-387	190	3	cyclical	cyclical	ADJ
admet-387	190	4	uric	uric	ADJ
admet-387	190	5	acid	acid	NOUN
admet-387	190	6	transport	transport	NOUN
admet-387	190	7	at	at	ADP
admet-387	190	8	the	the	DET
admet-387	190	9	proximal	proximal	ADJ
admet-387	190	10	tubule	tubule	NOUN
admet-387	190	11	membrane	membrane	NOUN
admet-387	190	12	the	the	DET
admet-387	190	13	result	result	NOUN
admet-387	190	14	of	of	ADP
admet-387	190	15	import	import	NOUN
admet-387	190	16	and	and	CCONJ
admet-387	190	17	export	export	NOUN
admet-387	190	18	transporters	transporter	NOUN
admet-387	190	19	coexpressed	coexpresse	VERB
admet-387	190	20	and	and	CCONJ
admet-387	190	21	functioning	function	VERB
admet-387	190	22	on	on	ADP
admet-387	190	23	both	both	CCONJ
admet-387	190	24	the	the	DET
admet-387	190	25	apical	apical	ADJ
admet-387	190	26	and	and	CCONJ
admet-387	190	27	tan	tan	PROPN
admet-387	190	28	and	and	CCONJ
admet-387	190	29	miner	miner	PROPN
admet-387	190	30	admet	admet	PROPN
admet-387	190	31	&	&	CCONJ
admet-387	190	32	dmpk	dmpk	PROPN
admet-387	190	33	5(2	5(2	NUM
admet-387	190	34	)	)	PUNCT
admet-387	190	35	(	(	PUNCT
admet-387	190	36	2017	2017	NUM
admet-387	190	37	)	)	PUNCT
admet-387	190	38	59	59	NUM
admet-387	190	39	-	-	SYM
admet-387	190	40	74	74	NUM
admet-387	190	41	68	68	NUM
admet-387	190	42	basolateral	basolateral	ADJ
admet-387	190	43	sides	side	NOUN
admet-387	190	44	of	of	ADP
admet-387	190	45	the	the	DET
admet-387	190	46	tubular	tubular	ADJ
admet-387	190	47	membrane	membrane	NOUN
admet-387	190	48	means	mean	VERB
admet-387	190	49	that	that	SCONJ
admet-387	190	50	uric	uric	ADJ
admet-387	190	51	acid	acid	NOUN
admet-387	190	52	likely	likely	ADJ
admet-387	190	53	cycles	cycle	NOUN
admet-387	190	54	through	through	ADP
admet-387	190	55	the	the	DET
admet-387	190	56	kidney	kidney	NOUN
admet-387	190	57	multiple	multiple	ADJ
admet-387	190	58	times	time	NOUN
admet-387	190	59	during	during	ADP
admet-387	190	60	the	the	DET
admet-387	190	61	day	day	NOUN
admet-387	190	62	and	and	CCONJ
admet-387	190	63	perhaps	perhaps	ADV
admet-387	190	64	within	within	ADP
admet-387	190	65	the	the	DET
admet-387	190	66	same	same	ADJ
admet-387	190	67	tubule	tubule	NOUN
admet-387	190	68	.	.	PUNCT
admet-387	191	1	the	the	DET
admet-387	191	2	renal	renal	ADJ
admet-387	191	3	system	system	NOUN
admet-387	191	4	filters	filter	VERB
admet-387	191	5	approximately	approximately	ADV
admet-387	191	6	180	180	NUM
admet-387	191	7	liters	liter	NOUN
admet-387	191	8	of	of	ADP
admet-387	191	9	water	water	NOUN
admet-387	191	10	each	each	DET
admet-387	191	11	day	day	NOUN
admet-387	191	12	,	,	PUNCT
admet-387	191	13	similarly	similarly	ADV
admet-387	191	14	for	for	ADP
admet-387	191	15	uric	uric	ADJ
admet-387	191	16	acid	acid	NOUN
admet-387	191	17	each	each	DET
admet-387	191	18	molecule	molecule	NOUN
admet-387	191	19	of	of	ADP
admet-387	191	20	uric	uric	ADJ
admet-387	191	21	acid	acid	NOUN
admet-387	191	22	is	be	AUX
admet-387	191	23	likely	likely	ADV
admet-387	191	24	subjected	subject	VERB
admet-387	191	25	to	to	ADP
admet-387	191	26	multiple	multiple	ADJ
admet-387	191	27	rounds	round	NOUN
admet-387	191	28	of	of	ADP
admet-387	191	29	filtration	filtration	NOUN
admet-387	191	30	,	,	PUNCT
admet-387	191	31	resorption	resorption	NOUN
admet-387	191	32	and	and	CCONJ
admet-387	191	33	/or	/or	ADV
admet-387	191	34	secretion	secretion	NOUN
admet-387	191	35	.	.	PUNCT
admet-387	192	1	the	the	DET
admet-387	192	2	relative	relative	ADJ
admet-387	192	3	affinity	affinity	NOUN
admet-387	192	4	and	and	CCONJ
admet-387	192	5	capacity	capacity	NOUN
admet-387	192	6	curves	curve	NOUN
admet-387	192	7	for	for	ADP
admet-387	192	8	these	these	DET
admet-387	192	9	transporters	transporter	NOUN
admet-387	192	10	govern	govern	VERB
admet-387	192	11	the	the	DET
admet-387	192	12	percentage	percentage	NOUN
admet-387	192	13	of	of	ADP
admet-387	192	14	uric	uric	ADJ
admet-387	192	15	acid	acid	NOUN
admet-387	192	16	that	that	PRON
admet-387	192	17	is	be	AUX
admet-387	192	18	resorbed	resorb	VERB
admet-387	192	19	,	,	PUNCT
admet-387	192	20	secreted	secrete	VERB
admet-387	192	21	and	and	CCONJ
admet-387	192	22	the	the	DET
admet-387	192	23	percentage	percentage	NOUN
admet-387	192	24	that	that	PRON
admet-387	192	25	finally	finally	ADV
admet-387	192	26	ends	end	VERB
admet-387	192	27	up	up	ADP
admet-387	192	28	excreted	excrete	VERB
admet-387	192	29	in	in	ADP
admet-387	192	30	urine	urine	NOUN
admet-387	192	31	[	[	X
admet-387	192	32	41	41	NUM
admet-387	192	33	]	]	PUNCT
admet-387	192	34	.	.	PUNCT
admet-387	193	1	a	a	DET
admet-387	193	2	similar	similar	ADJ
admet-387	193	3	process	process	NOUN
admet-387	193	4	is	be	AUX
admet-387	193	5	likely	likely	ADV
admet-387	193	6	also	also	ADV
admet-387	193	7	occurring	occur	VERB
admet-387	193	8	in	in	ADP
admet-387	193	9	the	the	DET
admet-387	193	10	intestine	intestine	NOUN
admet-387	193	11	.	.	PUNCT
admet-387	194	1	urat1	urat1	NOUN
admet-387	194	2	inhibitors	inhibitor	NOUN
admet-387	194	3	used	use	VERB
admet-387	194	4	for	for	ADP
admet-387	194	5	the	the	DET
admet-387	194	6	treatment	treatment	NOUN
admet-387	194	7	of	of	ADP
admet-387	194	8	gout	gout	NOUN
admet-387	194	9	(	(	PUNCT
admet-387	194	10	figure	figure	NOUN
admet-387	194	11	4	4	NUM
admet-387	194	12	)	)	PUNCT
admet-387	194	13	benzbromarone	benzbromarone	NOUN
admet-387	194	14	,	,	PUNCT
admet-387	194	15	(	(	PUNCT
admet-387	194	16	3,5	3,5	NUM
admet-387	194	17	-	-	PUNCT
admet-387	194	18	dibromo-4	dibromo-4	NOUN
admet-387	194	19	-	-	PUNCT
admet-387	194	20	hydroxyphenyl)-(2	hydroxyphenyl)-(2	NOUN
admet-387	194	21	-	-	PUNCT
admet-387	194	22	ethyl-1	ethyl-1	NUM
admet-387	194	23	-	-	PUNCT
admet-387	194	24	benzofuran-3	benzofuran-3	NOUN
admet-387	194	25	-	-	PUNCT
admet-387	194	26	yl)methanone	yl)methanone	NOUN
admet-387	194	27	benzbromarone	benzbromarone	NOUN
admet-387	194	28	was	be	AUX
admet-387	194	29	originally	originally	ADV
admet-387	194	30	derived	derive	VERB
admet-387	194	31	from	from	ADP
admet-387	194	32	benziodarone	benziodarone	NOUN
admet-387	194	33	,	,	PUNCT
admet-387	194	34	an	an	DET
admet-387	194	35	iodinated	iodinated	ADJ
admet-387	194	36	compound	compound	NOUN
admet-387	194	37	synthesized	synthesize	VERB
admet-387	194	38	initially	initially	ADV
admet-387	194	39	for	for	ADP
admet-387	194	40	coronary	coronary	ADJ
admet-387	194	41	dilation	dilation	NOUN
admet-387	194	42	.	.	PUNCT
admet-387	195	1	benziodarone	benziodarone	NOUN
admet-387	195	2	was	be	AUX
admet-387	195	3	withdrawn	withdraw	VERB
admet-387	195	4	from	from	ADP
admet-387	195	5	the	the	DET
admet-387	195	6	market	market	NOUN
admet-387	195	7	in	in	ADP
admet-387	195	8	europe	europe	PROPN
admet-387	195	9	due	due	ADP
admet-387	195	10	to	to	ADP
admet-387	195	11	instances	instance	NOUN
admet-387	195	12	of	of	ADP
admet-387	195	13	jaundice	jaundice	NOUN
admet-387	195	14	in	in	ADP
admet-387	195	15	patients	patient	NOUN
admet-387	195	16	treated	treat	VERB
admet-387	195	17	with	with	ADP
admet-387	195	18	this	this	DET
admet-387	195	19	compound	compound	NOUN
admet-387	195	20	.	.	PUNCT
admet-387	196	1	prior	prior	ADV
admet-387	196	2	to	to	ADP
admet-387	196	3	the	the	DET
admet-387	196	4	withdrawal	withdrawal	NOUN
admet-387	196	5	,	,	PUNCT
admet-387	196	6	it	it	PRON
admet-387	196	7	was	be	AUX
admet-387	196	8	noted	note	VERB
admet-387	196	9	that	that	SCONJ
admet-387	196	10	benziodarone	benziodarone	NOUN
admet-387	196	11	was	be	AUX
admet-387	196	12	an	an	DET
admet-387	196	13	effective	effective	ADJ
admet-387	196	14	uric	uric	ADJ
admet-387	196	15	acid	acid	NOUN
admet-387	196	16	lowering	lower	VERB
admet-387	196	17	agent	agent	NOUN
admet-387	196	18	.	.	PUNCT
admet-387	197	1	the	the	DET
admet-387	197	2	brominated	brominate	VERB
admet-387	197	3	analog	analog	NOUN
admet-387	197	4	of	of	ADP
admet-387	197	5	benziodarone	benziodarone	NOUN
admet-387	197	6	was	be	AUX
admet-387	197	7	synthesized	synthesize	VERB
admet-387	197	8	as	as	ADP
admet-387	197	9	a	a	DET
admet-387	197	10	follow	follow	NOUN
admet-387	197	11	up	up	ADP
admet-387	197	12	for	for	ADP
admet-387	197	13	uric	uric	ADJ
admet-387	197	14	acid	acid	NOUN
admet-387	197	15	lowering	lower	VERB
admet-387	197	16	in	in	ADP
admet-387	197	17	patients	patient	NOUN
admet-387	197	18	with	with	ADP
admet-387	197	19	gout	gout	NOUN
admet-387	197	20	(	(	PUNCT
admet-387	197	21	benzbromarone	benzbromarone	NOUN
admet-387	197	22	)	)	PUNCT
admet-387	198	1	[	[	X
admet-387	198	2	66	66	NUM
admet-387	198	3	]	]	PUNCT
admet-387	198	4	.	.	PUNCT
admet-387	199	1	this	this	DET
admet-387	199	2	compound	compound	NOUN
admet-387	199	3	was	be	AUX
admet-387	199	4	withdrawn	withdraw	VERB
admet-387	199	5	from	from	ADP
admet-387	199	6	the	the	DET
admet-387	199	7	market	market	NOUN
admet-387	199	8	later	later	ADV
admet-387	199	9	due	due	ADP
admet-387	199	10	to	to	ADP
admet-387	199	11	idiosyncratic	idiosyncratic	ADJ
admet-387	199	12	liver	liver	NOUN
admet-387	199	13	toxicity	toxicity	NOUN
admet-387	199	14	and	and	CCONJ
admet-387	199	15	is	be	AUX
admet-387	199	16	only	only	ADV
admet-387	199	17	used	use	VERB
admet-387	199	18	in	in	ADP
admet-387	199	19	europe	europe	PROPN
admet-387	199	20	on	on	ADP
admet-387	199	21	a	a	DET
admet-387	199	22	named	name	VERB
admet-387	199	23	patient	patient	ADJ
admet-387	199	24	basis	basis	NOUN
admet-387	199	25	.	.	PUNCT
admet-387	200	1	benzbromarone	benzbromarone	NOUN
admet-387	200	2	is	be	AUX
admet-387	200	3	capable	capable	ADJ
admet-387	200	4	of	of	ADP
admet-387	200	5	blocking	block	VERB
admet-387	200	6	urat1	urat1	NOUN
admet-387	200	7	potently	potently	ADV
admet-387	200	8	and	and	CCONJ
admet-387	200	9	selectively	selectively	ADV
admet-387	200	10	,	,	PUNCT
admet-387	200	11	it	it	PRON
admet-387	200	12	is	be	AUX
admet-387	200	13	relatively	relatively	ADV
admet-387	200	14	weak	weak	ADJ
admet-387	200	15	on	on	ADP
admet-387	200	16	both	both	CCONJ
admet-387	200	17	oat4	oat4	NOUN
admet-387	200	18	and	and	CCONJ
admet-387	200	19	on	on	ADP
admet-387	200	20	glut9	glut9	NOUN
admet-387	200	21	.	.	PUNCT
admet-387	201	1	the	the	DET
admet-387	201	2	pharmacokinetics	pharmacokinetic	NOUN
admet-387	201	3	of	of	ADP
admet-387	201	4	benzbromarone	benzbromarone	NOUN
admet-387	201	5	provide	provide	VERB
admet-387	201	6	for	for	ADP
admet-387	201	7	a	a	DET
admet-387	201	8	cmax	cmax	NOUN
admet-387	201	9	of	of	ADP
admet-387	201	10	approximately	approximately	ADV
admet-387	201	11	5	5	NUM
admet-387	201	12	μm	μm	NOUN
admet-387	202	1	[	[	X
admet-387	202	2	67	67	NUM
admet-387	202	3	]	]	PUNCT
admet-387	202	4	.	.	PUNCT
admet-387	203	1	this	this	PRON
admet-387	203	2	is	be	AUX
admet-387	203	3	well	well	ADV
admet-387	203	4	within	within	ADP
admet-387	203	5	the	the	DET
admet-387	203	6	potency	potency	NOUN
admet-387	203	7	on	on	ADP
admet-387	203	8	urat1	urat1	NOUN
admet-387	203	9	at	at	ADP
admet-387	203	10	100	100	NUM
admet-387	203	11	nm	nm	NOUN
admet-387	203	12	,	,	PUNCT
admet-387	203	13	however	however	ADV
admet-387	203	14	,	,	PUNCT
admet-387	203	15	the	the	DET
admet-387	203	16	high	high	ADJ
admet-387	203	17	μm	μm	NOUN
admet-387	203	18	potency	potency	NOUN
admet-387	203	19	on	on	ADP
admet-387	203	20	other	other	ADJ
admet-387	203	21	transporters	transporter	NOUN
admet-387	203	22	(	(	PUNCT
admet-387	203	23	glut9	glut9	NOUN
admet-387	203	24	and	and	CCONJ
admet-387	203	25	oat4	oat4	NOUN
admet-387	203	26	)	)	PUNCT
admet-387	203	27	in	in	ADP
admet-387	203	28	vitro	vitro	X
admet-387	203	29	,	,	PUNCT
admet-387	203	30	coupled	couple	VERB
admet-387	203	31	with	with	ADP
admet-387	203	32	the	the	DET
admet-387	203	33	relatively	relatively	ADV
admet-387	203	34	poor	poor	ADJ
admet-387	203	35	renal	renal	ADJ
admet-387	203	36	excretion	excretion	NOUN
admet-387	203	37	profile	profile	NOUN
admet-387	203	38	suggests	suggest	VERB
admet-387	203	39	that	that	SCONJ
admet-387	203	40	benzbromarone	benzbromarone	NOUN
admet-387	203	41	will	will	AUX
admet-387	203	42	primarily	primarily	ADV
admet-387	203	43	inhibit	inhibit	VERB
admet-387	203	44	urat1	urat1	NOUN
admet-387	203	45	to	to	PART
admet-387	203	46	produce	produce	VERB
admet-387	203	47	its	its	PRON
admet-387	203	48	uricosuric	uricosuric	ADJ
admet-387	203	49	effect	effect	NOUN
admet-387	203	50	.	.	PUNCT
admet-387	204	1	n	n	PRON
admet-387	204	2	s	s	VERB
admet-387	205	1	oh	oh	INTJ
admet-387	205	2	o	o	INTJ
admet-387	205	3	n	n	CCONJ
admet-387	205	4	n	n	CCONJ
admet-387	205	5	nn	nn	PROPN
admet-387	205	6	s	s	VERB
admet-387	206	1	oh	oh	INTJ
admet-387	206	2	o	o	INTJ
admet-387	206	3	br	br	INTJ
admet-387	206	4	o	o	INTJ
admet-387	206	5	br	br	INTJ
admet-387	207	1	br	br	INTJ
admet-387	208	1	oh	oh	INTJ
admet-387	208	2	o	o	INTJ
admet-387	209	1	o	o	X
admet-387	209	2	o	o	X
admet-387	209	3	n	n	CCONJ
admet-387	209	4	h	h	NOUN
admet-387	209	5	cl	cl	NOUN
admet-387	209	6	cf	cf	NOUN
admet-387	209	7	3	3	NUM
admet-387	209	8	o	o	NOUN
admet-387	209	9	o	o	NOUN
admet-387	210	1	n	n	ADP
admet-387	210	2	s	s	NOUN
admet-387	210	3	oho	oho	NOUN
admet-387	210	4	oo	oo	INTJ
admet-387	210	5	verinurad	verinurad	NOUN
admet-387	210	6	(	(	PUNCT
admet-387	210	7	rdea3170	rdea3170	PROPN
admet-387	210	8	)	)	PUNCT
admet-387	210	9	lesinurad	lesinurad	PROPN
admet-387	210	10	benzbromarone	benzbromarone	NOUN
admet-387	210	11	arhalofenate	arhalofenate	PROPN
admet-387	210	12	probenecid	probenecid	PROPN
admet-387	210	13	figure	figure	NOUN
admet-387	210	14	4	4	NUM
admet-387	210	15	.	.	PUNCT
admet-387	211	1	structure	structure	NOUN
admet-387	211	2	of	of	ADP
admet-387	211	3	urat1	urat1	NOUN
admet-387	211	4	inhibitors	inhibitor	NOUN
admet-387	211	5	for	for	ADP
admet-387	211	6	the	the	DET
admet-387	211	7	treatment	treatment	NOUN
admet-387	211	8	of	of	ADP
admet-387	211	9	gout	gout	NOUN
admet-387	211	10	.	.	PUNCT
admet-387	212	1	verinurad	verinurad	NOUN
admet-387	212	2	and	and	CCONJ
admet-387	212	3	arhalofenate	arhalofenate	NOUN
admet-387	212	4	are	be	AUX
admet-387	212	5	currently	currently	ADV
admet-387	212	6	under	under	ADP
admet-387	212	7	evaluation	evaluation	NOUN
admet-387	212	8	in	in	ADP
admet-387	212	9	clinical	clinical	ADJ
admet-387	212	10	trials	trial	NOUN
admet-387	212	11	.	.	PUNCT
admet-387	213	1	probenecid	probenecid	PROPN
admet-387	213	2	,	,	PUNCT
admet-387	213	3	4-[(dipropylamino	4-[(dipropylamino	NUM
admet-387	213	4	)	)	PUNCT
admet-387	213	5	sulfony1	sulfony1	PROPN
admet-387	213	6	]	]	PUNCT
admet-387	213	7	benzoic	benzoic	PROPN
admet-387	213	8	acid	acid	PROPN
admet-387	213	9	probenecid	probenecid	PROPN
admet-387	213	10	is	be	AUX
admet-387	213	11	a	a	DET
admet-387	213	12	compound	compound	NOUN
admet-387	213	13	originally	originally	ADV
admet-387	213	14	developed	develop	VERB
admet-387	213	15	by	by	ADP
admet-387	213	16	bayer	bayer	PROPN
admet-387	213	17	to	to	PART
admet-387	213	18	reduce	reduce	VERB
admet-387	213	19	the	the	DET
admet-387	213	20	renal	renal	ADJ
admet-387	213	21	excretion	excretion	NOUN
admet-387	213	22	of	of	ADP
admet-387	213	23	penicillin	penicillin	NOUN
admet-387	213	24	given	give	VERB
admet-387	213	25	the	the	DET
admet-387	213	26	difficulty	difficulty	NOUN
admet-387	213	27	in	in	ADP
admet-387	213	28	obtaining	obtain	VERB
admet-387	213	29	sufficient	sufficient	ADJ
admet-387	213	30	quantities	quantity	NOUN
admet-387	213	31	of	of	ADP
admet-387	213	32	antibiotic	antibiotic	NOUN
admet-387	213	33	to	to	PART
admet-387	213	34	cover	cover	VERB
admet-387	213	35	the	the	DET
admet-387	213	36	overwhelming	overwhelming	ADJ
admet-387	213	37	need	need	NOUN
admet-387	213	38	at	at	ADP
admet-387	213	39	that	that	DET
admet-387	213	40	time	time	NOUN
admet-387	213	41	.	.	PUNCT
admet-387	214	1	probenecid	probenecid	PROPN
admet-387	214	2	is	be	AUX
admet-387	214	3	an	an	DET
admet-387	214	4	inhibitor	inhibitor	NOUN
admet-387	214	5	of	of	ADP
admet-387	214	6	oat1	oat1	PROPN
admet-387	214	7	and	and	CCONJ
admet-387	214	8	oat3	oat3	PROPN
admet-387	214	9	,	,	PUNCT
admet-387	214	10	transporters	transporter	NOUN
admet-387	214	11	responsible	responsible	ADJ
admet-387	214	12	for	for	ADP
admet-387	214	13	renal	renal	ADJ
admet-387	214	14	excretion	excretion	NOUN
admet-387	214	15	of	of	ADP
admet-387	214	16	many	many	ADJ
admet-387	214	17	drugs	drug	NOUN
admet-387	214	18	not	not	PART
admet-387	214	19	just	just	ADV
admet-387	214	20	antibiotics	antibiotic	NOUN
admet-387	214	21	,	,	PUNCT
admet-387	214	22	thus	thus	ADV
admet-387	214	23	use	use	NOUN
admet-387	214	24	of	of	ADP
admet-387	214	25	probenecid	probenecid	PROPN
admet-387	214	26	is	be	AUX
admet-387	214	27	limited	limit	VERB
admet-387	214	28	due	due	ADP
admet-387	214	29	to	to	ADP
admet-387	214	30	the	the	DET
admet-387	214	31	significant	significant	ADJ
admet-387	214	32	drug	drug	NOUN
admet-387	214	33	-	-	PUNCT
admet-387	214	34	drug	drug	NOUN
admet-387	214	35	interactions	interaction	NOUN
admet-387	214	36	.	.	PUNCT
admet-387	215	1	admet	admet	PROPN
admet-387	215	2	&	&	CCONJ
admet-387	215	3	dmpk	dmpk	PROPN
admet-387	215	4	5(2	5(2	NUM
admet-387	215	5	)	)	PUNCT
admet-387	215	6	(	(	PUNCT
admet-387	215	7	2017	2017	NUM
admet-387	215	8	)	)	PUNCT
admet-387	215	9	59	59	NUM
admet-387	215	10	-	-	SYM
admet-387	215	11	74	74	NUM
admet-387	215	12	uric	uric	ADJ
admet-387	215	13	acid	acid	NOUN
admet-387	215	14	transporter	transporter	NOUN
admet-387	215	15	inhibitors	inhibitor	NOUN
admet-387	215	16	for	for	ADP
admet-387	215	17	gout	gout	NOUN
admet-387	215	18	doi	doi	NOUN
admet-387	215	19	:	:	PUNCT
admet-387	215	20	10.5599	10.5599	NUM
admet-387	215	21	/	/	SYM
admet-387	215	22	admet.5.1.387	admet.5.1.387	NUM
admet-387	215	23	69	69	NUM
admet-387	215	24	after	after	SCONJ
admet-387	215	25	the	the	DET
admet-387	215	26	use	use	NOUN
admet-387	215	27	of	of	ADP
admet-387	215	28	probenecid	probenecid	PROPN
admet-387	215	29	became	become	VERB
admet-387	215	30	widespread	widespread	ADJ
admet-387	215	31	in	in	ADP
admet-387	215	32	combination	combination	NOUN
admet-387	215	33	with	with	ADP
admet-387	215	34	antibiotics	antibiotic	NOUN
admet-387	215	35	,	,	PUNCT
admet-387	215	36	it	it	PRON
admet-387	215	37	was	be	AUX
admet-387	215	38	discovered	discover	VERB
admet-387	215	39	that	that	SCONJ
admet-387	215	40	it	it	PRON
admet-387	215	41	also	also	ADV
admet-387	215	42	reduced	reduce	VERB
admet-387	215	43	serum	serum	NOUN
admet-387	215	44	uric	uric	ADJ
admet-387	215	45	acid	acid	NOUN
admet-387	215	46	levels	level	NOUN
admet-387	215	47	by	by	ADP
admet-387	215	48	inhibition	inhibition	NOUN
admet-387	215	49	of	of	ADP
admet-387	215	50	renal	renal	ADJ
admet-387	215	51	reabsorption	reabsorption	NOUN
admet-387	215	52	,	,	PUNCT
admet-387	215	53	thus	thus	ADV
admet-387	215	54	making	make	VERB
admet-387	215	55	it	it	PRON
admet-387	215	56	useful	useful	ADJ
admet-387	215	57	for	for	ADP
admet-387	215	58	the	the	DET
admet-387	215	59	treatment	treatment	NOUN
admet-387	215	60	of	of	ADP
admet-387	215	61	gout	gout	NOUN
admet-387	215	62	.	.	PUNCT
admet-387	216	1	the	the	DET
admet-387	216	2	compound	compound	NOUN
admet-387	216	3	is	be	AUX
admet-387	216	4	still	still	ADV
admet-387	216	5	used	use	VERB
admet-387	216	6	for	for	ADP
admet-387	216	7	this	this	DET
admet-387	216	8	purpose	purpose	NOUN
admet-387	216	9	today	today	NOUN
admet-387	216	10	,	,	PUNCT
admet-387	216	11	though	though	SCONJ
admet-387	216	12	the	the	DET
admet-387	216	13	drug	drug	NOUN
admet-387	216	14	–	–	PUNCT
admet-387	216	15	drug	drug	NOUN
admet-387	216	16	interactions	interaction	NOUN
admet-387	216	17	,	,	PUNCT
admet-387	216	18	multiple	multiple	ADJ
admet-387	216	19	daily	daily	ADV
admet-387	216	20	dosing	dosing	NOUN
admet-387	216	21	and	and	CCONJ
admet-387	216	22	generally	generally	ADV
admet-387	216	23	weak	weak	ADJ
admet-387	216	24	efficacy	efficacy	NOUN
admet-387	216	25	limit	limit	VERB
admet-387	216	26	its	its	PRON
admet-387	216	27	use	use	NOUN
admet-387	216	28	overall	overall	ADV
admet-387	216	29	[	[	X
admet-387	216	30	68	68	NUM
admet-387	216	31	]	]	PUNCT
admet-387	216	32	.	.	PUNCT
admet-387	217	1	lesinurad	lesinurad	PROPN
admet-387	217	2	(	(	PUNCT
admet-387	217	3	rdea594	rdea594	PROPN
admet-387	217	4	)	)	PUNCT
admet-387	217	5	,	,	PUNCT
admet-387	217	6	2-((5	2-((5	PROPN
admet-387	217	7	-	-	PUNCT
admet-387	217	8	bromo-4-(4	bromo-4-(4	NOUN
admet-387	217	9	-	-	PUNCT
admet-387	217	10	cyclopropylnaphthalen-1	cyclopropylnaphthalen-1	NOUN
admet-387	217	11	-	-	PUNCT
admet-387	217	12	yl)-4h-1,2,4	yl)-4h-1,2,4	NOUN
admet-387	217	13	-	-	PUNCT
admet-387	217	14	triazol-3	triazol-3	NUM
admet-387	217	15	-	-	PUNCT
admet-387	217	16	yl)thio)acetic	yl)thio)acetic	NOUN
admet-387	217	17	acid	acid	NOUN
admet-387	217	18	lesinurad	lesinurad	NOUN
admet-387	217	19	was	be	AUX
admet-387	217	20	discovered	discover	VERB
admet-387	217	21	as	as	ADP
admet-387	217	22	an	an	DET
admet-387	217	23	active	active	ADJ
admet-387	217	24	metabolite	metabolite	NOUN
admet-387	217	25	from	from	ADP
admet-387	217	26	an	an	DET
admet-387	217	27	unrelated	unrelated	ADJ
admet-387	217	28	clinical	clinical	ADJ
admet-387	217	29	program	program	NOUN
admet-387	217	30	.	.	PUNCT
admet-387	218	1	patients	patient	NOUN
admet-387	218	2	given	give	VERB
admet-387	218	3	the	the	DET
admet-387	218	4	parent	parent	NOUN
admet-387	218	5	compound	compound	NOUN
admet-387	218	6	experienced	experience	VERB
admet-387	218	7	a	a	DET
admet-387	218	8	profound	profound	ADJ
admet-387	218	9	uric	uric	ADJ
admet-387	218	10	acid	acid	NOUN
admet-387	218	11	lowering	lower	VERB
admet-387	218	12	effect	effect	NOUN
admet-387	218	13	.	.	PUNCT
admet-387	219	1	this	this	DET
admet-387	219	2	effect	effect	NOUN
admet-387	219	3	was	be	AUX
admet-387	219	4	due	due	ADJ
admet-387	219	5	to	to	ADP
admet-387	219	6	drug	drug	NOUN
admet-387	219	7	-	-	PUNCT
admet-387	219	8	mediated	mediate	VERB
admet-387	219	9	alterations	alteration	NOUN
admet-387	219	10	in	in	ADP
admet-387	219	11	fractional	fractional	ADJ
admet-387	219	12	excretion	excretion	NOUN
admet-387	219	13	of	of	ADP
admet-387	219	14	uric	uric	ADJ
admet-387	219	15	acid	acid	NOUN
admet-387	220	1	[	[	X
admet-387	220	2	43	43	NUM
admet-387	220	3	]	]	PUNCT
admet-387	220	4	.	.	PUNCT
admet-387	221	1	this	this	DET
admet-387	221	2	result	result	NOUN
admet-387	221	3	suggested	suggest	VERB
admet-387	221	4	renal	renal	ADJ
admet-387	221	5	transporter	transporter	NOUN
admet-387	221	6	inhibition	inhibition	NOUN
admet-387	221	7	as	as	ADP
admet-387	221	8	the	the	DET
admet-387	221	9	mechanism	mechanism	NOUN
admet-387	221	10	.	.	PUNCT
admet-387	222	1	one	one	NUM
admet-387	222	2	metabolite	metabolite	NOUN
admet-387	222	3	from	from	ADP
admet-387	222	4	the	the	DET
admet-387	222	5	parent	parent	NOUN
admet-387	222	6	was	be	AUX
admet-387	222	7	preferentially	preferentially	ADV
admet-387	222	8	excreted	excrete	VERB
admet-387	222	9	to	to	ADP
admet-387	222	10	urine	urine	NOUN
admet-387	222	11	(	(	PUNCT
admet-387	222	12	rdea594	rdea594	PROPN
admet-387	222	13	)	)	PUNCT
admet-387	222	14	.	.	PUNCT
admet-387	223	1	purification	purification	NOUN
admet-387	223	2	and	and	CCONJ
admet-387	223	3	testing	testing	NOUN
admet-387	223	4	for	for	ADP
admet-387	223	5	urat1	urat1	NOUN
admet-387	223	6	inhibition	inhibition	NOUN
admet-387	223	7	provided	provide	VERB
admet-387	223	8	evidence	evidence	NOUN
admet-387	223	9	that	that	SCONJ
admet-387	223	10	rdea594	rdea594	PROPN
admet-387	223	11	(	(	PUNCT
admet-387	223	12	lesinurad	lesinurad	PROPN
admet-387	223	13	)	)	PUNCT
admet-387	223	14	was	be	AUX
admet-387	223	15	responsible	responsible	ADJ
admet-387	223	16	and	and	CCONJ
admet-387	223	17	likely	likely	ADV
admet-387	223	18	mediated	mediate	VERB
admet-387	223	19	its	its	PRON
admet-387	223	20	effects	effect	NOUN
admet-387	223	21	through	through	ADP
admet-387	223	22	inhibition	inhibition	NOUN
admet-387	223	23	of	of	ADP
admet-387	223	24	urat1	urat1	PROPN
admet-387	223	25	.	.	PUNCT
admet-387	224	1	this	this	PRON
admet-387	224	2	was	be	AUX
admet-387	224	3	later	later	ADV
admet-387	224	4	confirmed	confirm	VERB
admet-387	224	5	with	with	ADP
admet-387	224	6	human	human	ADJ
admet-387	224	7	pk	pk	PROPN
admet-387	224	8	/	/	SYM
admet-387	224	9	pd	pd	PROPN
admet-387	224	10	studies	study	NOUN
admet-387	224	11	in	in	ADP
admet-387	224	12	phase	phase	NOUN
admet-387	224	13	1	1	NUM
admet-387	224	14	[	[	X
admet-387	224	15	43	43	NUM
admet-387	224	16	]	]	PUNCT
admet-387	224	17	.	.	PUNCT
admet-387	225	1	lesinurad	lesinurad	PROPN
admet-387	225	2	is	be	AUX
admet-387	225	3	a	a	DET
admet-387	225	4	molecule	molecule	NOUN
admet-387	225	5	capable	capable	ADJ
admet-387	225	6	of	of	ADP
admet-387	225	7	significant	significant	ADJ
admet-387	225	8	uric	uric	ADJ
admet-387	225	9	acid	acid	NOUN
admet-387	225	10	lowering	lower	VERB
admet-387	225	11	in	in	ADP
admet-387	225	12	the	the	DET
admet-387	225	13	presence	presence	NOUN
admet-387	225	14	of	of	ADP
admet-387	225	15	an	an	DET
admet-387	225	16	xo	xo	PROPN
admet-387	225	17	inhibitor	inhibitor	NOUN
admet-387	225	18	via	via	ADP
admet-387	225	19	the	the	DET
admet-387	225	20	inhibition	inhibition	NOUN
admet-387	225	21	of	of	ADP
admet-387	225	22	urat1	urat1	PROPN
admet-387	225	23	.	.	PUNCT
admet-387	226	1	this	this	DET
admet-387	226	2	inhibition	inhibition	NOUN
admet-387	226	3	increases	increase	VERB
admet-387	226	4	the	the	DET
admet-387	226	5	feua	feua	NOUN
admet-387	226	6	in	in	ADP
admet-387	226	7	patients	patient	NOUN
admet-387	226	8	taking	take	VERB
admet-387	226	9	this	this	DET
admet-387	226	10	medicine	medicine	NOUN
admet-387	226	11	which	which	PRON
admet-387	226	12	targets	target	VERB
admet-387	226	13	the	the	DET
admet-387	226	14	defect	defect	NOUN
admet-387	226	15	found	find	VERB
admet-387	226	16	in	in	ADP
admet-387	226	17	most	most	ADJ
admet-387	226	18	gout	gout	NOUN
admet-387	226	19	patients	patient	NOUN
admet-387	226	20	.	.	PUNCT
admet-387	227	1	combination	combination	NOUN
admet-387	227	2	therapy	therapy	NOUN
admet-387	227	3	showed	show	VERB
admet-387	227	4	a	a	DET
admet-387	227	5	beneficial	beneficial	ADJ
admet-387	227	6	profile	profile	NOUN
admet-387	227	7	compared	compare	VERB
admet-387	227	8	to	to	ADP
admet-387	227	9	monotherapy	monotherapy	NOUN
admet-387	227	10	allopurinol	allopurinol	NOUN
admet-387	227	11	,	,	PUNCT
admet-387	227	12	however	however	ADV
admet-387	227	13	significant	significant	ADJ
admet-387	227	14	numbers	number	NOUN
admet-387	227	15	of	of	ADP
admet-387	227	16	patients	patient	NOUN
admet-387	227	17	experienced	experience	VERB
admet-387	227	18	creatinine	creatinine	NOUN
admet-387	227	19	elevations	elevation	NOUN
admet-387	227	20	while	while	SCONJ
admet-387	227	21	on	on	ADP
admet-387	227	22	lesinurad	lesinurad	NOUN
admet-387	227	23	thus	thus	ADV
admet-387	227	24	careful	careful	ADJ
admet-387	227	25	renal	renal	ADJ
admet-387	227	26	monitoring	monitoring	NOUN
admet-387	227	27	by	by	ADP
admet-387	227	28	prescribing	prescribe	VERB
admet-387	227	29	physicians	physician	NOUN
admet-387	227	30	is	be	AUX
admet-387	227	31	required	require	VERB
admet-387	227	32	.	.	PUNCT
admet-387	228	1	verinurad	verinurad	NOUN
admet-387	228	2	(	(	PUNCT
admet-387	228	3	rdea3170	rdea3170	PROPN
admet-387	228	4	)	)	PUNCT
admet-387	228	5	,	,	PUNCT
admet-387	228	6	2-((3-(4	2-((3-(4	PROPN
admet-387	228	7	-	-	PUNCT
admet-387	228	8	cyanonaphthalen-1	cyanonaphthalen-1	PROPN
admet-387	228	9	-	-	PUNCT
admet-387	228	10	yl)pyridin-4	yl)pyridin-4	PROPN
admet-387	228	11	-	-	PUNCT
admet-387	228	12	yl)thio)-2	yl)thio)-2	NOUN
admet-387	228	13	-	-	PUNCT
admet-387	228	14	methylpropanoic	methylpropanoic	ADJ
admet-387	228	15	acid	acid	NOUN
admet-387	228	16	verinurad	verinurad	NOUN
admet-387	228	17	is	be	AUX
admet-387	228	18	a	a	DET
admet-387	228	19	selective	selective	ADJ
admet-387	228	20	uric	uric	ADJ
admet-387	228	21	acid	acid	NOUN
admet-387	228	22	reabsorption	reabsorption	NOUN
admet-387	228	23	inhibitor	inhibitor	NOUN
admet-387	228	24	with	with	ADP
admet-387	228	25	nm	nm	ADJ
admet-387	228	26	potency	potency	NOUN
admet-387	228	27	against	against	ADP
admet-387	228	28	urat1	urat1	NOUN
admet-387	229	1	[	[	X
admet-387	229	2	69	69	NUM
admet-387	229	3	]	]	PUNCT
admet-387	229	4	.	.	PUNCT
admet-387	230	1	it	it	PRON
admet-387	230	2	is	be	AUX
admet-387	230	3	in	in	ADP
admet-387	230	4	clinical	clinical	ADJ
admet-387	230	5	development	development	NOUN
admet-387	230	6	for	for	ADP
admet-387	230	7	the	the	DET
admet-387	230	8	treatment	treatment	NOUN
admet-387	230	9	of	of	ADP
admet-387	230	10	gout	gout	NOUN
admet-387	230	11	and	and	CCONJ
admet-387	230	12	hyperuricemia	hyperuricemia	NOUN
admet-387	230	13	in	in	ADP
admet-387	230	14	combination	combination	NOUN
admet-387	230	15	with	with	ADP
admet-387	230	16	a	a	DET
admet-387	230	17	xanthine	xanthine	NOUN
admet-387	230	18	oxidase	oxidase	NOUN
admet-387	230	19	inhibitor	inhibitor	NOUN
admet-387	230	20	.	.	PUNCT
admet-387	231	1	in	in	ADP
admet-387	231	2	constrast	constrast	NOUN
admet-387	231	3	to	to	ADP
admet-387	231	4	lesinurad	lesinurad	NOUN
admet-387	231	5	,	,	PUNCT
admet-387	231	6	in	in	ADP
admet-387	231	7	phase	phase	NOUN
admet-387	231	8	2	2	NUM
admet-387	231	9	studies	study	NOUN
admet-387	231	10	in	in	ADP
admet-387	231	11	combination	combination	NOUN
admet-387	231	12	with	with	ADP
admet-387	231	13	a	a	DET
admet-387	231	14	xanthine	xanthine	NOUN
admet-387	231	15	oxidase	oxidase	NOUN
admet-387	231	16	inhibitor	inhibitor	NOUN
admet-387	231	17	,	,	PUNCT
admet-387	231	18	verinurad	verinurad	NOUN
admet-387	231	19	treatment	treatment	NOUN
admet-387	231	20	has	have	AUX
admet-387	231	21	not	not	PART
admet-387	231	22	resulted	result	VERB
admet-387	231	23	in	in	ADP
admet-387	231	24	serum	serum	NOUN
admet-387	231	25	creatinine	creatinine	NOUN
admet-387	231	26	elevations	elevation	NOUN
admet-387	231	27	,	,	PUNCT
admet-387	231	28	likely	likely	ADJ
admet-387	231	29	due	due	ADP
admet-387	231	30	to	to	ADP
admet-387	231	31	its	its	PRON
admet-387	231	32	pharmacodynamic	pharmacodynamic	ADJ
admet-387	231	33	/	/	SYM
admet-387	231	34	pharmacokinetic	pharmacokinetic	ADJ
admet-387	231	35	profile	profile	NOUN
admet-387	231	36	and	and	CCONJ
admet-387	231	37	the	the	DET
admet-387	231	38	action	action	NOUN
admet-387	231	39	of	of	ADP
admet-387	231	40	the	the	DET
admet-387	231	41	xanthine	xanthine	NOUN
admet-387	231	42	oxidase	oxidase	NOUN
admet-387	231	43	inhibitor	inhibitor	NOUN
admet-387	231	44	reducing	reduce	VERB
admet-387	231	45	the	the	DET
admet-387	231	46	urinary	urinary	ADJ
admet-387	231	47	uric	uric	ADJ
admet-387	231	48	acid	acid	NOUN
admet-387	231	49	concentration	concentration	NOUN
admet-387	231	50	and	and	CCONJ
admet-387	231	51	thereby	thereby	ADV
admet-387	231	52	reducing	reduce	VERB
admet-387	231	53	the	the	DET
admet-387	231	54	incidence	incidence	NOUN
admet-387	231	55	of	of	ADP
admet-387	231	56	uric	uric	ADJ
admet-387	231	57	acid	acid	NOUN
admet-387	231	58	crystallization	crystallization	NOUN
admet-387	231	59	and	and	CCONJ
admet-387	231	60	scr	scr	NOUN
admet-387	231	61	elevations	elevation	NOUN
admet-387	231	62	.	.	PUNCT
admet-387	232	1	the	the	DET
admet-387	232	2	combination	combination	NOUN
admet-387	232	3	of	of	ADP
admet-387	232	4	verinurad	verinurad	NOUN
admet-387	232	5	and	and	CCONJ
admet-387	232	6	a	a	DET
admet-387	232	7	xanthine	xanthine	NOUN
admet-387	232	8	oxidase	oxidase	NOUN
admet-387	232	9	inhibitor	inhibitor	NOUN
admet-387	232	10	provided	provide	VERB
admet-387	232	11	greater	great	ADJ
admet-387	232	12	reductions	reduction	NOUN
admet-387	232	13	in	in	ADP
admet-387	232	14	sua	sua	NOUN
admet-387	232	15	than	than	ADP
admet-387	232	16	by	by	ADP
admet-387	232	17	a	a	DET
admet-387	232	18	xanthine	xanthine	NOUN
admet-387	232	19	oxidase	oxidase	NOUN
admet-387	232	20	inhibitor	inhibitor	NOUN
admet-387	232	21	alone	alone	ADV
admet-387	232	22	even	even	ADV
admet-387	232	23	after	after	ADP
admet-387	232	24	doubling	double	VERB
admet-387	232	25	the	the	DET
admet-387	232	26	dose	dose	NOUN
admet-387	232	27	of	of	ADP
admet-387	232	28	the	the	DET
admet-387	232	29	xoi	xoi	NOUN
admet-387	233	1	[	[	X
admet-387	233	2	70	70	NUM
admet-387	233	3	]	]	PUNCT
admet-387	233	4	.	.	PUNCT
admet-387	234	1	arhalofenate	arhalofenate	ADJ
admet-387	234	2	,	,	PUNCT
admet-387	234	3	2	2	NUM
admet-387	234	4	-	-	NUM
admet-387	234	5	acetamidoethyl	acetamidoethyl	NOUN
admet-387	234	6	(	(	PUNCT
admet-387	234	7	2r)-2-(4	2r)-2-(4	NUM
admet-387	234	8	-	-	NOUN
admet-387	234	9	chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate	chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate	NOUN
admet-387	234	10	this	this	DET
admet-387	234	11	urat1	urat1	NOUN
admet-387	234	12	inhibitor	inhibitor	NOUN
admet-387	234	13	is	be	AUX
admet-387	234	14	currently	currently	ADV
admet-387	234	15	in	in	ADP
admet-387	234	16	clinical	clinical	ADJ
admet-387	234	17	trials	trial	NOUN
admet-387	234	18	for	for	ADP
admet-387	234	19	gout	gout	NOUN
admet-387	234	20	[	[	X
admet-387	234	21	71	71	NUM
admet-387	234	22	]	]	PUNCT
admet-387	234	23	.	.	PUNCT
admet-387	235	1	arhalofenate	arhalofenate	ADJ
admet-387	235	2	when	when	SCONJ
admet-387	235	3	dosed	dose	VERB
admet-387	235	4	at	at	ADP
admet-387	235	5	800	800	NUM
admet-387	235	6	mg	mg	NOUN
admet-387	235	7	per	per	ADP
admet-387	235	8	day	day	NOUN
admet-387	235	9	reduced	reduce	VERB
admet-387	235	10	serum	serum	NOUN
admet-387	235	11	uric	uric	ADJ
admet-387	235	12	acid	acid	NOUN
admet-387	235	13	similarly	similarly	ADV
admet-387	235	14	to	to	ADP
admet-387	235	15	300	300	NUM
admet-387	235	16	mg	mg	NOUN
admet-387	235	17	of	of	ADP
admet-387	235	18	allopurinol	allopurinol	NOUN
admet-387	235	19	.	.	PUNCT
admet-387	236	1	interestingly	interestingly	ADV
admet-387	236	2	,	,	PUNCT
admet-387	236	3	this	this	DET
admet-387	236	4	treatment	treatment	NOUN
admet-387	236	5	also	also	ADV
admet-387	236	6	decreased	decrease	VERB
admet-387	236	7	gout	gout	NOUN
admet-387	236	8	flares	flare	NOUN
admet-387	236	9	significantly	significantly	ADV
admet-387	236	10	compared	compare	VERB
admet-387	236	11	to	to	PART
admet-387	236	12	allopurinol	allopurinol	VERB
admet-387	236	13	at	at	ADP
admet-387	236	14	a	a	DET
admet-387	236	15	dosage	dosage	NOUN
admet-387	236	16	of	of	ADP
admet-387	236	17	300	300	NUM
admet-387	236	18	mg	mg	NOUN
admet-387	236	19	.	.	PUNCT
admet-387	237	1	arhalofenate	arhalofenate	PROPN
admet-387	237	2	was	be	AUX
admet-387	237	3	well	well	ADV
admet-387	237	4	tolerated	tolerate	VERB
admet-387	237	5	in	in	ADP
admet-387	237	6	early	early	ADJ
admet-387	237	7	trials	trial	NOUN
admet-387	237	8	.	.	PUNCT
admet-387	238	1	in	in	ADP
admet-387	238	2	addition	addition	NOUN
admet-387	238	3	to	to	ADP
admet-387	238	4	its	its	PRON
admet-387	238	5	uricosuric	uricosuric	ADJ
admet-387	238	6	properties	property	NOUN
admet-387	238	7	,	,	PUNCT
admet-387	238	8	it	it	PRON
admet-387	238	9	also	also	ADV
admet-387	238	10	appears	appear	VERB
admet-387	238	11	to	to	PART
admet-387	238	12	be	be	AUX
admet-387	238	13	capable	capable	ADJ
admet-387	238	14	of	of	ADP
admet-387	238	15	reducing	reduce	VERB
admet-387	238	16	inflammation	inflammation	NOUN
admet-387	238	17	.	.	PUNCT
admet-387	239	1	this	this	DET
admet-387	239	2	effect	effect	NOUN
admet-387	239	3	could	could	AUX
admet-387	239	4	lead	lead	VERB
admet-387	239	5	to	to	ADP
admet-387	239	6	reductions	reduction	NOUN
admet-387	239	7	in	in	ADP
admet-387	239	8	flares	flare	NOUN
admet-387	239	9	during	during	ADP
admet-387	239	10	treatment	treatment	NOUN
admet-387	239	11	though	though	SCONJ
admet-387	239	12	the	the	DET
admet-387	239	13	data	datum	NOUN
admet-387	239	14	to	to	ADP
admet-387	239	15	date	date	NOUN
admet-387	239	16	is	be	AUX
admet-387	239	17	inconclusive	inconclusive	ADJ
admet-387	239	18	.	.	PUNCT
admet-387	240	1	combination	combination	NOUN
admet-387	240	2	studies	study	NOUN
admet-387	240	3	are	be	AUX
admet-387	240	4	underway	underway	ADJ
admet-387	240	5	and	and	CCONJ
admet-387	240	6	development	development	NOUN
admet-387	240	7	is	be	AUX
admet-387	240	8	continuing	continue	VERB
admet-387	240	9	in	in	ADP
admet-387	240	10	the	the	DET
admet-387	240	11	us	us	PROPN
admet-387	240	12	.	.	PUNCT
admet-387	241	1	binding	bind	VERB
admet-387	241	2	of	of	ADP
admet-387	241	3	known	known	ADJ
admet-387	241	4	inhibitors	inhibitor	NOUN
admet-387	241	5	the	the	DET
admet-387	241	6	interactions	interaction	NOUN
admet-387	241	7	between	between	ADP
admet-387	241	8	uricosuric	uricosuric	ADJ
admet-387	241	9	agents	agent	NOUN
admet-387	241	10	and	and	CCONJ
admet-387	241	11	urat1	urat1	NOUN
admet-387	241	12	has	have	AUX
admet-387	241	13	been	be	AUX
admet-387	241	14	studied	study	VERB
admet-387	241	15	using	use	VERB
admet-387	241	16	modeling	modeling	NOUN
admet-387	241	17	and	and	CCONJ
admet-387	241	18	chimeric	chimeric	ADJ
admet-387	241	19	mapping	mapping	NOUN
admet-387	241	20	studies	study	NOUN
admet-387	241	21	[	[	X
admet-387	241	22	41	41	NUM
admet-387	241	23	]	]	PUNCT
admet-387	241	24	.	.	PUNCT
admet-387	242	1	this	this	DET
admet-387	242	2	work	work	NOUN
admet-387	242	3	has	have	AUX
admet-387	242	4	demonstrated	demonstrate	VERB
admet-387	242	5	that	that	SCONJ
admet-387	242	6	the	the	DET
admet-387	242	7	urat1	urat1	NOUN
admet-387	242	8	inhibitors	inhibitor	NOUN
admet-387	242	9	(	(	PUNCT
admet-387	242	10	lesinurad	lesinurad	PROPN
admet-387	242	11	,	,	PUNCT
admet-387	242	12	probenecid	probenecid	PROPN
admet-387	242	13	,	,	PUNCT
admet-387	242	14	benzbromarone	benzbromarone	NOUN
admet-387	242	15	and	and	CCONJ
admet-387	242	16	rdea3170	rdea3170	PROPN
admet-387	242	17	(	(	PUNCT
admet-387	242	18	verinurad	verinurad	NOUN
admet-387	242	19	)	)	PUNCT
admet-387	242	20	all	all	PRON
admet-387	242	21	bind	bind	VERB
admet-387	242	22	to	to	ADP
admet-387	242	23	the	the	DET
admet-387	242	24	same	same	ADJ
admet-387	242	25	site	site	NOUN
admet-387	242	26	in	in	ADP
admet-387	242	27	the	the	DET
admet-387	242	28	transporter	transporter	NOUN
admet-387	242	29	[	[	X
admet-387	242	30	41	41	NUM
admet-387	242	31	]	]	PUNCT
admet-387	242	32	.	.	PUNCT
admet-387	243	1	there	there	PRON
admet-387	243	2	are	be	VERB
admet-387	243	3	interesting	interesting	ADJ
admet-387	243	4	differences	difference	NOUN
admet-387	243	5	in	in	ADP
admet-387	243	6	the	the	DET
admet-387	243	7	specific	specific	ADJ
admet-387	243	8	amino	amino	NOUN
admet-387	243	9	acids	acid	NOUN
admet-387	243	10	required	require	VERB
admet-387	243	11	for	for	ADP
admet-387	243	12	binding	bind	VERB
admet-387	243	13	for	for	ADP
admet-387	243	14	each	each	DET
admet-387	243	15	compound	compound	NOUN
admet-387	243	16	but	but	CCONJ
admet-387	243	17	this	this	PRON
admet-387	243	18	is	be	AUX
admet-387	243	19	not	not	PART
admet-387	243	20	surprising	surprising	ADJ
admet-387	243	21	given	give	VERB
admet-387	243	22	the	the	DET
admet-387	243	23	structural	structural	ADJ
admet-387	243	24	differences	difference	NOUN
admet-387	243	25	between	between	ADP
admet-387	243	26	them	they	PRON
admet-387	243	27	.	.	PUNCT
admet-387	244	1	it	it	PRON
admet-387	244	2	’s	’	VERB
admet-387	244	3	likely	likely	ADJ
admet-387	244	4	that	that	SCONJ
admet-387	244	5	there	there	PRON
admet-387	244	6	is	be	VERB
admet-387	244	7	a	a	DET
admet-387	244	8	specific	specific	ADJ
admet-387	244	9	characteristic	characteristic	NOUN
admet-387	244	10	of	of	ADP
admet-387	244	11	this	this	DET
admet-387	244	12	location	location	NOUN
admet-387	244	13	within	within	ADP
admet-387	244	14	the	the	DET
admet-387	244	15	transporter	transporter	NOUN
admet-387	244	16	that	that	PRON
admet-387	244	17	makes	make	VERB
admet-387	244	18	it	it	PRON
admet-387	244	19	susceptible	susceptible	ADJ
admet-387	244	20	to	to	ADP
admet-387	244	21	inhibition	inhibition	NOUN
admet-387	244	22	by	by	ADP
admet-387	244	23	a	a	DET
admet-387	244	24	wide	wide	ADJ
admet-387	244	25	variety	variety	NOUN
admet-387	244	26	of	of	ADP
admet-387	244	27	compounds	compound	NOUN
admet-387	244	28	.	.	PUNCT
admet-387	245	1	tan	tan	PROPN
admet-387	245	2	and	and	CCONJ
admet-387	245	3	miner	miner	PROPN
admet-387	245	4	admet	admet	PROPN
admet-387	245	5	&	&	CCONJ
admet-387	245	6	dmpk	dmpk	PROPN
admet-387	245	7	5(2	5(2	NUM
admet-387	245	8	)	)	PUNCT
admet-387	245	9	(	(	PUNCT
admet-387	245	10	2017	2017	NUM
admet-387	245	11	)	)	PUNCT
admet-387	245	12	59	59	NUM
admet-387	245	13	-	-	SYM
admet-387	245	14	74	74	NUM
admet-387	245	15	70	70	NUM
admet-387	245	16	one	one	NUM
admet-387	245	17	of	of	ADP
admet-387	245	18	these	these	DET
admet-387	245	19	characteristics	characteristic	NOUN
admet-387	245	20	may	may	AUX
admet-387	245	21	be	be	AUX
admet-387	245	22	that	that	PRON
admet-387	245	23	uric	uric	ADJ
admet-387	245	24	acid	acid	NOUN
admet-387	245	25	itself	itself	PRON
admet-387	245	26	appears	appear	VERB
admet-387	245	27	to	to	PART
admet-387	245	28	interact	interact	VERB
admet-387	245	29	with	with	ADP
admet-387	245	30	this	this	DET
admet-387	245	31	pocket	pocket	NOUN
admet-387	245	32	.	.	PUNCT
admet-387	246	1	modeling	modeling	NOUN
admet-387	246	2	of	of	ADP
admet-387	246	3	the	the	DET
admet-387	246	4	relevant	relevant	ADJ
admet-387	246	5	amino	amino	NOUN
admet-387	246	6	acids	acid	NOUN
admet-387	246	7	onto	onto	ADP
admet-387	246	8	and	and	CCONJ
admet-387	246	9	oat1	oat1	PROPN
admet-387	246	10	scaffold	scaffold	NOUN
admet-387	246	11	suggests	suggest	VERB
admet-387	246	12	that	that	SCONJ
admet-387	246	13	these	these	DET
admet-387	246	14	amino	amino	ADJ
admet-387	246	15	acids	acid	NOUN
admet-387	246	16	are	be	AUX
admet-387	246	17	located	locate	VERB
admet-387	246	18	within	within	ADP
admet-387	246	19	the	the	DET
admet-387	246	20	interior	interior	ADJ
admet-387	246	21	channel	channel	NOUN
admet-387	246	22	of	of	ADP
admet-387	246	23	the	the	DET
admet-387	246	24	transporter	transporter	NOUN
admet-387	246	25	,	,	PUNCT
admet-387	246	26	ideally	ideally	ADV
admet-387	246	27	positioned	position	VERB
admet-387	246	28	to	to	PART
admet-387	246	29	bind	bind	VERB
admet-387	246	30	either	either	DET
admet-387	246	31	substrate	substrate	NOUN
admet-387	246	32	or	or	CCONJ
admet-387	246	33	inhibitor	inhibitor	NOUN
admet-387	246	34	[	[	X
admet-387	246	35	41	41	NUM
admet-387	246	36	]	]	PUNCT
admet-387	246	37	.	.	PUNCT
admet-387	247	1	conclusions	conclusion	NOUN
admet-387	247	2	human	human	ADJ
admet-387	247	3	uric	uric	ADJ
admet-387	247	4	acid	acid	NOUN
admet-387	247	5	level	level	NOUN
admet-387	247	6	in	in	ADP
admet-387	247	7	serum	serum	NOUN
admet-387	247	8	is	be	AUX
admet-387	247	9	regulated	regulate	VERB
admet-387	247	10	by	by	ADP
admet-387	247	11	a	a	DET
admet-387	247	12	complex	complex	ADJ
admet-387	247	13	array	array	NOUN
admet-387	247	14	of	of	ADP
admet-387	247	15	multi	multi	ADJ
admet-387	247	16	-	-	ADJ
admet-387	247	17	protein	protein	ADJ
admet-387	247	18	complexes	complex	NOUN
admet-387	247	19	found	find	VERB
admet-387	247	20	in	in	ADP
admet-387	247	21	several	several	ADJ
admet-387	247	22	different	different	ADJ
admet-387	247	23	organs	organ	NOUN
admet-387	247	24	.	.	PUNCT
admet-387	248	1	evolutionary	evolutionary	ADJ
admet-387	248	2	pressure	pressure	NOUN
admet-387	248	3	to	to	PART
admet-387	248	4	increase	increase	VERB
admet-387	248	5	uric	uric	ADJ
admet-387	248	6	acid	acid	NOUN
admet-387	248	7	levels	level	NOUN
admet-387	248	8	likely	likely	ADV
admet-387	248	9	resulted	result	VERB
admet-387	248	10	in	in	ADP
admet-387	248	11	the	the	DET
admet-387	248	12	need	need	NOUN
admet-387	248	13	to	to	PART
admet-387	248	14	regulate	regulate	VERB
admet-387	248	15	these	these	DET
admet-387	248	16	levels	level	NOUN
admet-387	248	17	.	.	PUNCT
admet-387	249	1	the	the	DET
admet-387	249	2	kidney	kidney	NOUN
admet-387	249	3	plays	play	VERB
admet-387	249	4	the	the	DET
admet-387	249	5	key	key	ADJ
admet-387	249	6	role	role	NOUN
admet-387	249	7	by	by	ADP
admet-387	249	8	sensing	sense	VERB
admet-387	249	9	current	current	ADJ
admet-387	249	10	uric	uric	ADJ
admet-387	249	11	acid	acid	NOUN
admet-387	249	12	levels	level	NOUN
admet-387	249	13	from	from	ADP
admet-387	249	14	the	the	DET
admet-387	249	15	blood	blood	NOUN
admet-387	249	16	in	in	ADP
admet-387	249	17	the	the	DET
admet-387	249	18	filtrate	filtrate	NOUN
admet-387	249	19	and	and	CCONJ
admet-387	249	20	adjusting	adjust	VERB
admet-387	249	21	reabsorption	reabsorption	NOUN
admet-387	249	22	accordingly	accordingly	ADV
admet-387	249	23	.	.	PUNCT
admet-387	250	1	the	the	DET
admet-387	250	2	intestine	intestine	NOUN
admet-387	250	3	is	be	AUX
admet-387	250	4	also	also	ADV
admet-387	250	5	likely	likely	ADV
admet-387	250	6	capable	capable	ADJ
admet-387	250	7	of	of	ADP
admet-387	250	8	sensing	sense	VERB
admet-387	250	9	and	and	CCONJ
admet-387	250	10	responding	respond	VERB
admet-387	250	11	to	to	PART
admet-387	250	12	serum	serum	VERB
admet-387	250	13	uric	uric	ADJ
admet-387	250	14	acid	acid	NOUN
admet-387	250	15	levels	level	NOUN
admet-387	250	16	,	,	PUNCT
admet-387	250	17	however	however	ADV
admet-387	250	18	,	,	PUNCT
admet-387	250	19	it	it	PRON
admet-387	250	20	is	be	AUX
admet-387	250	21	less	less	ADV
admet-387	250	22	well	well	ADV
admet-387	250	23	characterized	characterized	ADJ
admet-387	250	24	.	.	PUNCT
admet-387	251	1	the	the	DET
admet-387	251	2	risks	risk	NOUN
admet-387	251	3	of	of	ADP
admet-387	251	4	elevated	elevated	ADJ
admet-387	251	5	uric	uric	ADJ
admet-387	251	6	acid	acid	NOUN
admet-387	251	7	are	be	AUX
admet-387	251	8	well	well	ADV
admet-387	251	9	characterized	characterized	ADJ
admet-387	251	10	and	and	CCONJ
admet-387	251	11	a	a	DET
admet-387	251	12	number	number	NOUN
admet-387	251	13	of	of	ADP
admet-387	251	14	therapies	therapy	NOUN
admet-387	251	15	have	have	AUX
admet-387	251	16	been	be	AUX
admet-387	251	17	developed	develop	VERB
admet-387	251	18	to	to	PART
admet-387	251	19	reduce	reduce	VERB
admet-387	251	20	these	these	DET
admet-387	251	21	levels	level	NOUN
admet-387	251	22	in	in	ADP
admet-387	251	23	patients	patient	NOUN
admet-387	251	24	with	with	ADP
admet-387	251	25	gout	gout	NOUN
admet-387	251	26	.	.	PUNCT
admet-387	252	1	urat1	urat1	NOUN
admet-387	252	2	inhibitors	inhibitor	NOUN
admet-387	252	3	represent	represent	VERB
admet-387	252	4	one	one	NUM
admet-387	252	5	of	of	ADP
admet-387	252	6	the	the	DET
admet-387	252	7	two	two	NUM
admet-387	252	8	main	main	ADJ
admet-387	252	9	approaches	approach	NOUN
admet-387	252	10	for	for	ADP
admet-387	252	11	reduction	reduction	NOUN
admet-387	252	12	of	of	ADP
admet-387	252	13	serum	serum	NOUN
admet-387	252	14	uric	uric	ADJ
admet-387	252	15	acid	acid	NOUN
admet-387	252	16	and	and	CCONJ
admet-387	252	17	work	work	NOUN
admet-387	252	18	by	by	ADP
admet-387	252	19	increasing	increase	VERB
admet-387	252	20	the	the	DET
admet-387	252	21	efficiency	efficiency	NOUN
admet-387	252	22	of	of	ADP
admet-387	252	23	uric	uric	ADJ
admet-387	252	24	acid	acid	NOUN
admet-387	252	25	excretion	excretion	NOUN
admet-387	252	26	.	.	PUNCT
admet-387	253	1	the	the	DET
admet-387	253	2	other	other	ADJ
admet-387	253	3	relies	rely	VERB
admet-387	253	4	on	on	ADP
admet-387	253	5	the	the	DET
admet-387	253	6	blockade	blockade	NOUN
admet-387	253	7	production	production	NOUN
admet-387	253	8	of	of	ADP
admet-387	253	9	uric	uric	ADJ
admet-387	253	10	acid	acid	NOUN
admet-387	253	11	via	via	ADP
admet-387	253	12	inhibition	inhibition	NOUN
admet-387	253	13	of	of	ADP
admet-387	253	14	xanthine	xanthine	NOUN
admet-387	253	15	oxidase	oxidase	NOUN
admet-387	253	16	.	.	PUNCT
admet-387	254	1	combination	combination	NOUN
admet-387	254	2	therapy	therapy	NOUN
admet-387	254	3	with	with	ADP
admet-387	254	4	both	both	CCONJ
admet-387	254	5	an	an	DET
admet-387	254	6	excretion	excretion	NOUN
admet-387	254	7	enhancer	enhancer	NOUN
admet-387	254	8	and	and	CCONJ
admet-387	254	9	a	a	DET
admet-387	254	10	production	production	NOUN
admet-387	254	11	inhibitor	inhibitor	NOUN
admet-387	254	12	is	be	AUX
admet-387	254	13	a	a	DET
admet-387	254	14	powerful	powerful	ADJ
admet-387	254	15	approach	approach	NOUN
admet-387	254	16	to	to	ADP
admet-387	254	17	efficient	efficient	ADJ
admet-387	254	18	urate	urate	NOUN
admet-387	254	19	lowering	lower	VERB
admet-387	254	20	therapy	therapy	NOUN
admet-387	254	21	.	.	PUNCT
admet-387	255	1	references	reference	NOUN
admet-387	255	2	[	[	X
admet-387	255	3	1	1	X
admet-387	255	4	]	]	PUNCT
admet-387	255	5	d.	d.	PROPN
admet-387	255	6	khanna	khanna	PROPN
admet-387	255	7	,	,	PUNCT
admet-387	255	8	j.d	j.d	PROPN
admet-387	255	9	.	.	PROPN
admet-387	255	10	fitzgerald	fitzgerald	PROPN
admet-387	255	11	,	,	PUNCT
admet-387	255	12	p.p	p.p	PROPN
admet-387	255	13	.	.	PROPN
admet-387	255	14	khanna	khanna	PROPN
admet-387	255	15	,	,	PUNCT
admet-387	255	16	s.	s.	PROPN
admet-387	255	17	bae	bae	PROPN
admet-387	255	18	,	,	PUNCT
admet-387	255	19	m.k	m.k	PROPN
admet-387	255	20	.	.	PROPN
admet-387	255	21	singh	singh	PROPN
admet-387	255	22	,	,	PUNCT
admet-387	255	23	t.	t.	PROPN
admet-387	255	24	neogi	neogi	PROPN
admet-387	255	25	,	,	PUNCT
admet-387	255	26	et	et	PROPN
admet-387	255	27	al	al	PROPN
admet-387	255	28	.	.	PUNCT
admet-387	256	1	arthritis	arthritis	PROPN
admet-387	256	2	care	care	PROPN
admet-387	256	3	&	&	CCONJ
admet-387	256	4	research	research	PROPN
admet-387	256	5	64	64	NUM
admet-387	256	6	(	(	PUNCT
admet-387	256	7	2012	2012	NUM
admet-387	256	8	)	)	PUNCT
admet-387	256	9	1431	1431	NUM
admet-387	256	10	-	-	SYM
admet-387	256	11	1446	1446	NUM
admet-387	256	12	.	.	PUNCT
admet-387	257	1	[	[	X
admet-387	257	2	2	2	NUM
admet-387	257	3	]	]	X
admet-387	257	4	s.g	s.g	PROPN
admet-387	257	5	.	.	PROPN
admet-387	257	6	mallat	mallat	PROPN
admet-387	257	7	,	,	PUNCT
admet-387	257	8	s.	s.	PROPN
admet-387	257	9	al	al	PROPN
admet-387	257	10	kattar	kattar	PROPN
admet-387	257	11	,	,	PUNCT
admet-387	257	12	b.y	b.y	PROPN
admet-387	257	13	.	.	PROPN
admet-387	257	14	tanios	tanio	NOUN
admet-387	257	15	,	,	PUNCT
admet-387	257	16	a.	a.	NOUN
admet-387	257	17	jurjus	jurju	NOUN
admet-387	257	18	,	,	PUNCT
admet-387	257	19	current	current	ADJ
admet-387	257	20	hypertension	hypertension	NOUN
admet-387	257	21	reports	report	VERB
admet-387	257	22	18	18	NUM
admet-387	257	23	(	(	PUNCT
admet-387	257	24	2016	2016	NUM
admet-387	257	25	)	)	PUNCT
admet-387	257	26	74	74	NUM
admet-387	257	27	.	.	PUNCT
admet-387	258	1	[	[	X
admet-387	258	2	3	3	X
admet-387	258	3	]	]	X
admet-387	258	4	j.t	j.t	PROPN
admet-387	258	5	.	.	PROPN
admet-387	258	6	kratzer	kratzer	PROPN
admet-387	258	7	,	,	PUNCT
admet-387	258	8	m.a	m.a	PROPN
admet-387	258	9	.	.	PROPN
admet-387	258	10	lanaspa	lanaspa	PROPN
admet-387	258	11	,	,	PUNCT
admet-387	258	12	m.n	m.n	PROPN
admet-387	258	13	.	.	PROPN
admet-387	258	14	murphy	murphy	PROPN
admet-387	258	15	,	,	PUNCT
admet-387	258	16	c.	c.	PROPN
admet-387	258	17	cicerchi	cicerchi	PROPN
admet-387	258	18	,	,	PUNCT
admet-387	258	19	c.l	c.l	PROPN
admet-387	258	20	.	.	PROPN
admet-387	258	21	graves	grave	NOUN
admet-387	258	22	,	,	PUNCT
admet-387	258	23	p.a	p.a	PROPN
admet-387	258	24	.	.	PROPN
admet-387	258	25	tipton	tipton	PROPN
admet-387	258	26	,	,	PUNCT
admet-387	258	27	e.a	e.a	PROPN
admet-387	258	28	.	.	PROPN
admet-387	258	29	et	et	PROPN
admet-387	258	30	al	al	PROPN
admet-387	258	31	.	.	PUNCT
admet-387	258	32	proceedings	proceeding	NOUN
admet-387	258	33	of	of	ADP
admet-387	258	34	the	the	DET
admet-387	258	35	national	national	PROPN
admet-387	258	36	academy	academy	PROPN
admet-387	258	37	of	of	ADP
admet-387	258	38	sciences	sciences	PROPN
admet-387	258	39	of	of	ADP
admet-387	258	40	the	the	DET
admet-387	258	41	united	united	PROPN
admet-387	258	42	states	states	PROPN
admet-387	258	43	of	of	ADP
admet-387	258	44	america	america	PROPN
admet-387	258	45	111	111	NUM
admet-387	258	46	(	(	PUNCT
admet-387	258	47	2014	2014	NUM
admet-387	258	48	)	)	PUNCT
admet-387	258	49	3763	3763	NUM
admet-387	258	50	-	-	SYM
admet-387	258	51	3768	3768	NUM
admet-387	258	52	.	.	PUNCT
admet-387	259	1	[	[	X
admet-387	259	2	4	4	NUM
admet-387	259	3	]	]	X
admet-387	259	4	m.b	m.b	PROPN
admet-387	259	5	.	.	PROPN
admet-387	259	6	bridgeman	bridgeman	PROPN
admet-387	259	7	,	,	PUNCT
admet-387	259	8	b.	b.	PROPN
admet-387	259	9	chavez	chavez	PROPN
admet-387	259	10	,	,	PUNCT
admet-387	259	11	expert	expert	ADJ
admet-387	259	12	opinion	opinion	NOUN
admet-387	259	13	on	on	ADP
admet-387	259	14	pharmacotherapy	pharmacotherapy	NOUN
admet-387	259	15	16	16	NUM
admet-387	259	16	(	(	PUNCT
admet-387	259	17	2015	2015	NUM
admet-387	259	18	)	)	PUNCT
admet-387	259	19	395	395	NUM
admet-387	259	20	-	-	SYM
admet-387	259	21	398	398	NUM
admet-387	259	22	.	.	PUNCT
admet-387	260	1	[	[	X
admet-387	260	2	5	5	NUM
admet-387	260	3	]	]	PUNCT
admet-387	260	4	k.	k.	PROPN
admet-387	260	5	sakhaee	sakhaee	PROPN
admet-387	260	6	,	,	PUNCT
admet-387	260	7	journal	journal	NOUN
admet-387	260	8	of	of	ADP
admet-387	260	9	nephrology	nephrology	NOUN
admet-387	260	10	27	27	NUM
admet-387	260	11	(	(	PUNCT
admet-387	260	12	2014	2014	NUM
admet-387	260	13	)	)	PUNCT
admet-387	260	14	241	241	NUM
admet-387	260	15	-	-	SYM
admet-387	260	16	245	245	NUM
admet-387	260	17	.	.	PUNCT
admet-387	261	1	[	[	X
admet-387	261	2	6	6	NUM
admet-387	261	3	]	]	PUNCT
admet-387	261	4	m.	m.	NOUN
admet-387	261	5	kolz	kolz	PROPN
admet-387	261	6	,	,	PUNCT
admet-387	261	7	t.	t.	PROPN
admet-387	261	8	johnson	johnson	PROPN
admet-387	261	9	,	,	PUNCT
admet-387	261	10	s.	s.	PROPN
admet-387	261	11	sanna	sanna	PROPN
admet-387	261	12	,	,	PUNCT
admet-387	261	13	a.	a.	PROPN
admet-387	261	14	teumer	teumer	PROPN
admet-387	261	15	,	,	PUNCT
admet-387	261	16	v.	v.	ADP
admet-387	261	17	vitart	vitart	NOUN
admet-387	261	18	,	,	PUNCT
admet-387	261	19	m.	m.	PROPN
admet-387	261	20	perola	perola	PROPN
admet-387	261	21	,	,	PUNCT
admet-387	261	22	et	et	PROPN
admet-387	261	23	al	al	PROPN
admet-387	261	24	.	.	PROPN
admet-387	261	25	plos	plos	PROPN
admet-387	261	26	genetics	genetics	PROPN
admet-387	261	27	5	5	NUM
admet-387	261	28	(	(	PUNCT
admet-387	261	29	2009	2009	NUM
admet-387	261	30	)	)	PUNCT
admet-387	261	31	e1000504	e1000504	NOUN
admet-387	261	32	.	.	PUNCT
admet-387	262	1	[	[	X
admet-387	262	2	7	7	NUM
admet-387	262	3	]	]	PUNCT
admet-387	262	4	a.	a.	NOUN
admet-387	262	5	kottgen	kottgen	PROPN
admet-387	262	6	,	,	PUNCT
admet-387	262	7	e.	e.	PROPN
admet-387	262	8	albrecht	albrecht	PROPN
admet-387	262	9	,	,	PUNCT
admet-387	262	10	a.	a.	PROPN
admet-387	262	11	teumer	teumer	PROPN
admet-387	262	12	,	,	PUNCT
admet-387	262	13	v.	v.	ADP
admet-387	262	14	vitart	vitart	PROPN
admet-387	262	15	,	,	PUNCT
admet-387	262	16	j.	j.	PROPN
admet-387	262	17	krumsiek	krumsiek	PROPN
admet-387	262	18	,	,	PUNCT
admet-387	262	19	c.	c.	PROPN
admet-387	262	20	hundertmark	hundertmark	PROPN
admet-387	262	21	,	,	PUNCT
admet-387	263	1	et	et	PROPN
admet-387	263	2	al	al	PROPN
admet-387	263	3	.	.	PROPN
admet-387	263	4	nature	nature	PROPN
admet-387	263	5	genetics	genetics	PROPN
admet-387	263	6	45	45	NUM
admet-387	263	7	(	(	PUNCT
admet-387	263	8	2013	2013	NUM
admet-387	263	9	)	)	PUNCT
admet-387	263	10	145	145	NUM
admet-387	263	11	-	-	SYM
admet-387	263	12	154	154	NUM
admet-387	263	13	.	.	PUNCT
admet-387	264	1	[	[	X
admet-387	264	2	8	8	NUM
admet-387	264	3	]	]	X
admet-387	264	4	c.	c.	NOUN
admet-387	264	5	tanner	tanner	PROPN
admet-387	264	6	,	,	PUNCT
admet-387	264	7	j.	j.	PROPN
admet-387	264	8	boocock	boocock	PROPN
admet-387	264	9	,	,	PUNCT
admet-387	264	10	e.a	e.a	PROPN
admet-387	264	11	.	.	PROPN
admet-387	264	12	stahl	stahl	PROPN
admet-387	264	13	,	,	PUNCT
admet-387	264	14	a.	a.	NOUN
admet-387	264	15	dobbyn	dobbyn	PROPN
admet-387	264	16	,	,	PUNCT
admet-387	264	17	a.k	a.k	PROPN
admet-387	264	18	.	.	PROPN
admet-387	264	19	mandal	mandal	PROPN
admet-387	264	20	,	,	PUNCT
admet-387	264	21	m.	m.	NOUN
admet-387	264	22	cadzow	cadzow	NOUN
admet-387	264	23	,	,	PUNCT
admet-387	264	24	a.j	a.j	PROPN
admet-387	264	25	.	.	PROPN
admet-387	264	26	phipps	phipps	PROPN
admet-387	264	27	-	-	PUNCT
admet-387	264	28	green	green	PROPN
admet-387	264	29	,	,	PUNCT
admet-387	264	30	r.k	r.k	PROPN
admet-387	264	31	.	.	PROPN
admet-387	264	32	topless	topless	PROPN
admet-387	264	33	,	,	PUNCT
admet-387	264	34	j.	j.	PROPN
admet-387	264	35	harre	harre	PROPN
admet-387	264	36	hindmarsh	hindmarsh	PROPN
admet-387	264	37	,	,	PUNCT
admet-387	264	38	l.k	l.k	PROPN
admet-387	264	39	.	.	PROPN
admet-387	264	40	stamp	stamp	PROPN
admet-387	264	41	,	,	PUNCT
admet-387	264	42	n.	n.	PROPN
admet-387	264	43	dalbeth	dalbeth	PROPN
admet-387	264	44	,	,	PUNCT
admet-387	264	45	h.k	h.k	PROPN
admet-387	264	46	.	.	PROPN
admet-387	264	47	choi	choi	PROPN
admet-387	264	48	,	,	PUNCT
admet-387	264	49	d.b	d.b	PROPN
admet-387	264	50	.	.	PROPN
admet-387	264	51	mount	mount	PROPN
admet-387	264	52	,	,	PUNCT
admet-387	264	53	t.r	t.r	PROPN
admet-387	264	54	.	.	PROPN
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admet-387	264	56	,	,	PUNCT
admet-387	264	57	arthritis	arthritis	PROPN
admet-387	264	58	&	&	CCONJ
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admet-387	264	60	(	(	PUNCT
admet-387	264	61	2017	2017	NUM
admet-387	264	62	)	)	PUNCT
admet-387	264	63	.	.	PUNCT
admet-387	265	1	[	[	X
admet-387	265	2	9	9	NUM
admet-387	265	3	]	]	PUNCT
admet-387	265	4	x.	x.	NOUN
admet-387	265	5	xu	xu	PROPN
admet-387	265	6	,	,	PUNCT
admet-387	265	7	c.	c.	PROPN
admet-387	265	8	li	li	PROPN
admet-387	265	9	,	,	PUNCT
admet-387	265	10	p.	p.	PROPN
admet-387	265	11	zhou	zhou	PROPN
admet-387	265	12	,	,	PUNCT
admet-387	265	13	t.	t.	PROPN
admet-387	265	14	jiang	jiang	PROPN
admet-387	265	15	,	,	PUNCT
admet-387	265	16	pharmaceutical	pharmaceutical	NOUN
admet-387	265	17	biology	biology	NOUN
admet-387	265	18	54	54	NUM
admet-387	265	19	(	(	PUNCT
admet-387	265	20	2016	2016	NUM
admet-387	265	21	)	)	PUNCT
admet-387	265	22	3151	3151	NUM
admet-387	265	23	-	-	SYM
admet-387	265	24	3155	3155	NUM
admet-387	265	25	.	.	PUNCT
admet-387	266	1	[	[	X
admet-387	266	2	10	10	NUM
admet-387	266	3	]	]	PUNCT
admet-387	266	4	t.	t.	PROPN
admet-387	266	5	takada	takada	PROPN
admet-387	266	6	,	,	PUNCT
admet-387	266	7	k.	k.	PROPN
admet-387	266	8	ichida	ichida	PROPN
admet-387	266	9	,	,	PUNCT
admet-387	266	10	h.	h.	PROPN
admet-387	266	11	matsuo	matsuo	PROPN
admet-387	266	12	,	,	PUNCT
admet-387	266	13	a.	a.	NOUN
admet-387	266	14	nakayama	nakayama	PROPN
admet-387	266	15	,	,	PUNCT
admet-387	266	16	k.	k.	PROPN
admet-387	266	17	murakami	murakami	PROPN
admet-387	266	18	,	,	PUNCT
admet-387	266	19	y.	y.	PROPN
admet-387	266	20	yamanashi	yamanashi	PROPN
admet-387	266	21	,	,	PUNCT
admet-387	266	22	h.	h.	PROPN
admet-387	266	23	kasuga	kasuga	PROPN
admet-387	266	24	,	,	PUNCT
admet-387	266	25	n.	n.	PROPN
admet-387	266	26	shinomiya	shinomiya	PROPN
admet-387	266	27	,	,	PUNCT
admet-387	266	28	h.	h.	PROPN
admet-387	266	29	suzuki	suzuki	PROPN
admet-387	266	30	,	,	PUNCT
admet-387	266	31	nucleosides	nucleoside	VERB
admet-387	266	32	,	,	PUNCT
admet-387	266	33	nucleotides	nucleotide	NOUN
admet-387	266	34	&	&	CCONJ
admet-387	266	35	nucleic	nucleic	ADJ
admet-387	266	36	acids	acid	NOUN
admet-387	266	37	33	33	NUM
admet-387	266	38	(	(	PUNCT
admet-387	266	39	2014	2014	NUM
admet-387	266	40	)	)	PUNCT
admet-387	266	41	275	275	NUM
admet-387	266	42	-	-	SYM
admet-387	266	43	281	281	NUM
admet-387	266	44	.	.	PUNCT
admet-387	267	1	[	[	X
admet-387	267	2	11	11	NUM
admet-387	267	3	]	]	PUNCT
admet-387	267	4	a.	a.	NOUN
admet-387	267	5	nakayama	nakayama	PROPN
admet-387	267	6	,	,	PUNCT
admet-387	267	7	h.	h.	PROPN
admet-387	267	8	matsuo	matsuo	PROPN
admet-387	267	9	,	,	PUNCT
admet-387	267	10	t.	t.	PROPN
admet-387	267	11	takada	takada	PROPN
admet-387	267	12	,	,	PUNCT
admet-387	267	13	k.	k.	PROPN
admet-387	267	14	ichida	ichida	PROPN
admet-387	267	15	,	,	PUNCT
admet-387	267	16	t.	t.	PROPN
admet-387	267	17	nakamura	nakamura	PROPN
admet-387	267	18	,	,	PUNCT
admet-387	267	19	y.	y.	PROPN
admet-387	267	20	ikebuchi	ikebuchi	PROPN
admet-387	267	21	,	,	PUNCT
admet-387	267	22	k.	k.	PROPN
admet-387	267	23	ito	ito	PROPN
admet-387	267	24	,	,	PUNCT
admet-387	267	25	t.	t.	PROPN
admet-387	267	26	hosoya	hosoya	PROPN
admet-387	267	27	,	,	PUNCT
admet-387	267	28	y.	y.	PROPN
admet-387	267	29	kanai	kanai	PROPN
admet-387	267	30	,	,	PUNCT
admet-387	267	31	h.	h.	PROPN
admet-387	267	32	suzuki	suzuki	PROPN
admet-387	267	33	,	,	PUNCT
admet-387	267	34	n.	n.	PROPN
admet-387	267	35	shinomiya	shinomiya	PROPN
admet-387	267	36	,	,	PUNCT
admet-387	267	37	nucleosides	nucleoside	NOUN
admet-387	267	38	,	,	PUNCT
admet-387	267	39	nucleotides	nucleotide	NOUN
admet-387	267	40	&	&	CCONJ
admet-387	267	41	nucleic	nucleic	ADJ
admet-387	267	42	acids	acid	NOUN
admet-387	267	43	30	30	NUM
admet-387	267	44	(	(	PUNCT
admet-387	267	45	2011	2011	NUM
admet-387	267	46	)	)	PUNCT
admet-387	267	47	1091	1091	NUM
admet-387	267	48	-	-	SYM
admet-387	267	49	1097	1097	NUM
admet-387	267	50	.	.	PUNCT
admet-387	268	1	[	[	X
admet-387	268	2	12	12	NUM
admet-387	268	3	]	]	PUNCT
admet-387	268	4	a.	a.	NOUN
admet-387	268	5	hosomi	hosomi	PROPN
admet-387	268	6	,	,	PUNCT
admet-387	268	7	t.	t.	PROPN
admet-387	268	8	nakanishi	nakanishi	PROPN
admet-387	268	9	,	,	PUNCT
admet-387	268	10	t.	t.	PROPN
admet-387	268	11	fujita	fujita	PROPN
admet-387	268	12	,	,	PUNCT
admet-387	268	13	i.	i.	PROPN
admet-387	268	14	tamai	tamai	PROPN
admet-387	268	15	,	,	PUNCT
admet-387	268	16	plos	plos	PROPN
admet-387	268	17	one	one	NUM
admet-387	268	18	7	7	NUM
admet-387	268	19	(	(	PUNCT
admet-387	268	20	2012	2012	NUM
admet-387	268	21	)	)	PUNCT
admet-387	268	22	e30456	e30456	NOUN
admet-387	268	23	.	.	PUNCT
admet-387	269	1	[	[	X
admet-387	269	2	13	13	NUM
admet-387	269	3	]	]	PUNCT
admet-387	269	4	m.	m.	NOUN
admet-387	269	5	hiratochi	hiratochi	PROPN
admet-387	269	6	,	,	PUNCT
admet-387	269	7	k.	k.	PROPN
admet-387	269	8	tatani	tatani	PROPN
admet-387	269	9	,	,	PUNCT
admet-387	269	10	k.	k.	PROPN
admet-387	269	11	shimizu	shimizu	PROPN
admet-387	269	12	,	,	PUNCT
admet-387	269	13	y.	y.	PROPN
admet-387	269	14	kuramochi	kuramochi	PROPN
admet-387	269	15	,	,	PUNCT
admet-387	269	16	n.	n.	PROPN
admet-387	269	17	kikuchi	kikuchi	PROPN
admet-387	269	18	,	,	PUNCT
admet-387	269	19	n.	n.	PROPN
admet-387	269	20	kamada	kamada	PROPN
admet-387	269	21	,	,	PUNCT
admet-387	269	22	f.	f.	PROPN
admet-387	269	23	itoh	itoh	PROPN
admet-387	269	24	,	,	PUNCT
admet-387	269	25	m.	m.	NOUN
admet-387	269	26	isaji	isaji	PROPN
admet-387	269	27	,	,	PUNCT
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admet-387	269	32	690	690	NUM
admet-387	269	33	(	(	PUNCT
admet-387	269	34	2012	2012	NUM
admet-387	269	35	)	)	PUNCT
admet-387	269	36	183	183	NUM
admet-387	269	37	-	-	SYM
admet-387	269	38	191	191	NUM
admet-387	269	39	.	.	PUNCT
admet-387	270	1	[	[	X
admet-387	270	2	14	14	NUM
admet-387	270	3	]	]	PUNCT
admet-387	270	4	s.	s.	PROPN
admet-387	270	5	liu	liu	PROPN
admet-387	270	6	,	,	PUNCT
admet-387	270	7	f.	f.	PROPN
admet-387	270	8	perez	perez	PROPN
admet-387	270	9	-	-	PUNCT
admet-387	270	10	ruiz	ruiz	NOUN
admet-387	270	11	,	,	PUNCT
admet-387	270	12	j.n	j.n	PROPN
admet-387	270	13	.	.	PROPN
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admet-387	270	15	,	,	PUNCT
admet-387	270	16	joint	joint	NOUN
admet-387	270	17	,	,	PUNCT
admet-387	270	18	bone	bone	NOUN
admet-387	270	19	,	,	PUNCT
admet-387	270	20	spine	spine	NOUN
admet-387	270	21	:	:	PUNCT
admet-387	270	22	revue	revue	PROPN
admet-387	270	23	du	du	PROPN
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admet-387	270	26	(	(	PUNCT
admet-387	270	27	2017	2017	NUM
admet-387	270	28	)	)	PUNCT
admet-387	270	29	183	183	NUM
admet-387	270	30	-	-	SYM
admet-387	270	31	188	188	NUM
admet-387	270	32	.	.	PUNCT
admet-387	271	1	[	[	X
admet-387	271	2	15	15	NUM
admet-387	271	3	]	]	PUNCT
admet-387	271	4	a.	a.	NOUN
admet-387	271	5	enomoto	enomoto	NOUN
admet-387	271	6	,	,	PUNCT
admet-387	271	7	h.	h.	PROPN
admet-387	271	8	kimura	kimura	PROPN
admet-387	271	9	,	,	PUNCT
admet-387	271	10	a.	a.	NOUN
admet-387	271	11	chairoungdua	chairoungdua	PROPN
admet-387	271	12	,	,	PUNCT
admet-387	271	13	y.	y.	PROPN
admet-387	271	14	shigeta	shigeta	PROPN
admet-387	271	15	,	,	PUNCT
admet-387	271	16	p.	p.	NOUN
admet-387	271	17	jutabha	jutabha	NOUN
admet-387	271	18	,	,	PUNCT
admet-387	271	19	s.h	s.h	PROPN
admet-387	271	20	.	.	PROPN
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admet-387	271	22	,	,	PUNCT
admet-387	271	23	et	et	PROPN
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admet-387	271	25	.	.	PUNCT
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admet-387	271	27	417	417	NUM
admet-387	271	28	(	(	PUNCT
admet-387	271	29	2002	2002	NUM
admet-387	271	30	)	)	PUNCT
admet-387	271	31	447	447	NUM
admet-387	271	32	-	-	SYM
admet-387	271	33	452	452	NUM
admet-387	271	34	.	.	PUNCT
admet-387	272	1	[	[	X
admet-387	272	2	16	16	NUM
admet-387	272	3	]	]	X
admet-387	272	4	p.h	p.h	PROPN
admet-387	272	5	.	.	PROPN
admet-387	272	6	gois	gois	PROPN
admet-387	272	7	,	,	PUNCT
admet-387	272	8	e.r	e.r	PROPN
admet-387	272	9	.	.	PROPN
admet-387	272	10	souza	souza	PROPN
admet-387	272	11	,	,	PUNCT
admet-387	272	12	the	the	DET
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admet-387	272	14	database	database	NOUN
admet-387	272	15	of	of	ADP
admet-387	272	16	systematic	systematic	ADJ
admet-387	272	17	reviews	review	NOUN
admet-387	272	18	(	(	PUNCT
admet-387	272	19	2013	2013	NUM
admet-387	272	20	)	)	PUNCT
admet-387	272	21	cd008652	cd008652	PROPN
admet-387	272	22	.	.	PUNCT
admet-387	273	1	[	[	X
admet-387	273	2	17	17	NUM
admet-387	273	3	]	]	X
admet-387	273	4	a.s	a.s	PROPN
admet-387	273	5	.	.	PROPN
admet-387	273	6	kydd	kydd	PROPN
admet-387	273	7	,	,	PUNCT
admet-387	273	8	r.	r.	PROPN
admet-387	273	9	seth	seth	PROPN
admet-387	273	10	,	,	PUNCT
admet-387	273	11	r.	r.	PROPN
admet-387	273	12	buchbinder	buchbinder	PROPN
admet-387	273	13	,	,	PUNCT
admet-387	273	14	l.	l.	PROPN
admet-387	273	15	falzon	falzon	PROPN
admet-387	273	16	,	,	PUNCT
admet-387	273	17	c.j	c.j	PROPN
admet-387	273	18	.	.	PROPN
admet-387	273	19	edwards	edwards	PROPN
admet-387	273	20	,	,	PUNCT
admet-387	273	21	d.m	d.m	PROPN
admet-387	273	22	.	.	PUNCT
admet-387	273	23	van	van	PROPN
admet-387	273	24	der	der	PROPN
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admet-387	273	26	,	,	PUNCT
admet-387	273	27	c.	c.	PROPN
admet-387	273	28	bombardier	bombardier	PROPN
admet-387	273	29	,	,	PUNCT
admet-387	273	30	the	the	DET
admet-387	273	31	journal	journal	NOUN
admet-387	273	32	of	of	ADP
admet-387	273	33	rheumatology	rheumatology	NOUN
admet-387	273	34	.	.	PUNCT
admet-387	274	1	supplement	supplement	VERB
admet-387	274	2	92	92	NUM
admet-387	274	3	(	(	PUNCT
admet-387	274	4	2014	2014	NUM
admet-387	274	5	)	)	PUNCT
admet-387	274	6	33	33	NUM
admet-387	274	7	-	-	SYM
admet-387	274	8	41	41	NUM
admet-387	274	9	.	.	PUNCT
admet-387	275	1	admet	admet	PROPN
admet-387	275	2	&	&	CCONJ
admet-387	275	3	dmpk	dmpk	PROPN
admet-387	275	4	5(2	5(2	NUM
admet-387	275	5	)	)	PUNCT
admet-387	275	6	(	(	PUNCT
admet-387	275	7	2017	2017	NUM
admet-387	275	8	)	)	PUNCT
admet-387	275	9	59	59	NUM
admet-387	275	10	-	-	SYM
admet-387	275	11	74	74	NUM
admet-387	275	12	uric	uric	ADJ
admet-387	275	13	acid	acid	NOUN
admet-387	275	14	transporter	transporter	NOUN
admet-387	275	15	inhibitors	inhibitor	NOUN
admet-387	275	16	for	for	ADP
admet-387	275	17	gout	gout	NOUN
admet-387	275	18	doi	doi	NOUN
admet-387	275	19	:	:	PUNCT
admet-387	275	20	10.5599	10.5599	NUM
admet-387	275	21	/	/	SYM
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admet-387	275	23	71	71	NUM
admet-387	276	1	[	[	SYM
admet-387	276	2	18	18	NUM
admet-387	276	3	]	]	X
admet-387	276	4	c.s	c.s	PROPN
admet-387	276	5	.	.	PROPN
admet-387	276	6	lieber	lieber	PROPN
admet-387	276	7	,	,	PUNCT
admet-387	276	8	d.p	d.p	PROPN
admet-387	276	9	.	.	PROPN
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admet-387	276	11	,	,	PUNCT
admet-387	276	12	m.s	m.s	PROPN
admet-387	276	13	.	.	PROPN
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admet-387	276	15	,	,	PUNCT
admet-387	276	16	c.s	c.s	PROPN
admet-387	276	17	.	.	PROPN
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admet-387	276	19	,	,	PUNCT
admet-387	276	20	the	the	DET
admet-387	276	21	journal	journal	NOUN
admet-387	276	22	of	of	ADP
admet-387	276	23	clinical	clinical	ADJ
admet-387	276	24	investigation	investigation	NOUN
admet-387	276	25	41	41	NUM
admet-387	276	26	(	(	PUNCT
admet-387	276	27	1962	1962	NUM
admet-387	276	28	)	)	PUNCT
admet-387	276	29	1863	1863	NUM
admet-387	276	30	-	-	SYM
admet-387	276	31	1870	1870	NUM
admet-387	276	32	.	.	PUNCT
admet-387	277	1	[	[	X
admet-387	277	2	19	19	NUM
admet-387	277	3	]	]	X
admet-387	277	4	j.	j.	PROPN
admet-387	277	5	padova	padova	PROPN
admet-387	277	6	,	,	PUNCT
admet-387	277	7	g.	g.	PROPN
admet-387	277	8	bendersky	bendersky	PROPN
admet-387	277	9	,	,	PUNCT
admet-387	277	10	the	the	DET
admet-387	277	11	new	new	PROPN
admet-387	277	12	england	england	PROPN
admet-387	277	13	journal	journal	PROPN
admet-387	277	14	of	of	ADP
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admet-387	277	16	267	267	NUM
admet-387	277	17	(	(	PUNCT
admet-387	277	18	1962	1962	NUM
admet-387	277	19	)	)	PUNCT
admet-387	277	20	530	530	NUM
admet-387	277	21	-	-	SYM
admet-387	277	22	534	534	NUM
admet-387	277	23	.	.	PUNCT
admet-387	278	1	[	[	X
admet-387	278	2	20	20	NUM
admet-387	278	3	]	]	X
admet-387	278	4	r.l	r.l	PROPN
admet-387	278	5	.	.	PROPN
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admet-387	278	7	,	,	PUNCT
admet-387	278	8	r.t	r.t	PROPN
admet-387	278	9	.	.	PROPN
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admet-387	278	11	,	,	PUNCT
admet-387	278	12	current	current	ADJ
admet-387	278	13	rheumatology	rheumatology	NOUN
admet-387	278	14	reports	report	VERB
admet-387	278	15	15	15	NUM
admet-387	278	16	(	(	PUNCT
admet-387	278	17	2013	2013	NUM
admet-387	278	18	)	)	PUNCT
admet-387	278	19	309	309	NUM
admet-387	278	20	.	.	PUNCT
admet-387	279	1	[	[	X
admet-387	279	2	21	21	NUM
admet-387	279	3	]	]	X
admet-387	279	4	k.	k.	PROPN
admet-387	279	5	ebert	ebert	PROPN
admet-387	279	6	,	,	PUNCT
admet-387	279	7	m.	m.	PROPN
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admet-387	279	9	,	,	PUNCT
admet-387	279	10	k.e	k.e	PROPN
admet-387	279	11	.	.	PROPN
admet-387	279	12	geillinger	geillinger	PROPN
admet-387	279	13	,	,	PUNCT
admet-387	279	14	g.c	g.c	PROPN
admet-387	279	15	.	.	PROPN
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admet-387	279	17	,	,	PUNCT
admet-387	279	18	j.	j.	PROPN
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admet-387	279	20	,	,	PUNCT
admet-387	279	21	j.	j.	PROPN
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admet-387	279	23	,	,	PUNCT
admet-387	279	24	h.	h.	PROPN
admet-387	279	25	daniel	daniel	PROPN
admet-387	279	26	,	,	PUNCT
admet-387	279	27	h.	h.	PROPN
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admet-387	279	29	,	,	PUNCT
admet-387	279	30	the	the	DET
admet-387	279	31	journal	journal	NOUN
admet-387	279	32	of	of	ADP
admet-387	279	33	membrane	membrane	NOUN
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admet-387	279	36	(	(	PUNCT
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admet-387	279	38	)	)	PUNCT
admet-387	279	39	171	171	NUM
admet-387	279	40	-	-	SYM
admet-387	279	41	182	182	NUM
admet-387	279	42	.	.	PUNCT
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admet-387	280	2	22	22	NUM
admet-387	280	3	]	]	X
admet-387	280	4	k.	k.	PROPN
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admet-387	281	2	,	,	PUNCT
admet-387	281	3	k.m	k.m	PROPN
admet-387	281	4	.	.	PROPN
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admet-387	281	6	,	,	PUNCT
admet-387	281	7	s.y	s.y	PROPN
admet-387	281	8	.	.	PROPN
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admet-387	281	11	a.m.	a.m.	PROPN
admet-387	281	12	ng	ng	PROPN
admet-387	281	13	,	,	PUNCT
admet-387	281	14	d.	d.	PROPN
admet-387	281	15	o'neill	o'neill	PROPN
admet-387	281	16	,	,	PUNCT
admet-387	281	17	e.	e.	PROPN
admet-387	281	18	karpinski	karpinski	PROPN
admet-387	281	19	,	,	PUNCT
admet-387	281	20	j.d	j.d	PROPN
admet-387	281	21	.	.	PROPN
admet-387	281	22	young	young	PROPN
admet-387	281	23	,	,	PUNCT
admet-387	281	24	c.i	c.i	PROPN
admet-387	281	25	.	.	PROPN
admet-387	281	26	cheeseman	cheeseman	PROPN
admet-387	281	27	,	,	PUNCT
admet-387	281	28	american	american	PROPN
admet-387	281	29	journal	journal	PROPN
admet-387	281	30	of	of	ADP
admet-387	281	31	physiology	physiology	NOUN
admet-387	281	32	.	.	PUNCT
admet-387	282	1	renal	renal	ADJ
admet-387	282	2	physiology	physiology	NOUN
admet-387	282	3	303	303	NUM
admet-387	282	4	(	(	PUNCT
admet-387	282	5	2012	2012	NUM
admet-387	282	6	)	)	PUNCT
admet-387	282	7	f527	f527	PROPN
admet-387	282	8	-	-	PUNCT
admet-387	282	9	539	539	NUM
admet-387	282	10	.	.	PUNCT
admet-387	283	1	[	[	X
admet-387	283	2	23	23	NUM
admet-387	283	3	]	]	PUNCT
admet-387	283	4	t.	t.	NOUN
admet-387	283	5	kimura	kimura	PROPN
admet-387	283	6	,	,	PUNCT
admet-387	283	7	m.	m.	PROPN
admet-387	283	8	takahashi	takahashi	PROPN
admet-387	283	9	,	,	PUNCT
admet-387	283	10	k.	k.	PROPN
admet-387	283	11	yan	yan	PROPN
admet-387	283	12	,	,	PUNCT
admet-387	283	13	h.	h.	PROPN
admet-387	283	14	sakurai	sakurai	PROPN
admet-387	283	15	,	,	PUNCT
admet-387	283	16	plos	plos	PROPN
admet-387	283	17	one	one	NUM
admet-387	283	18	9	9	NUM
admet-387	283	19	(	(	PUNCT
admet-387	283	20	2014	2014	NUM
admet-387	283	21	)	)	PUNCT
admet-387	283	22	e84996	e84996	NOUN
admet-387	283	23	.	.	PUNCT
admet-387	284	1	[	[	X
admet-387	284	2	24	24	NUM
admet-387	284	3	]	]	X
admet-387	284	4	j.e	j.e	PROPN
admet-387	284	5	.	.	PROPN
admet-387	284	6	shima	shima	PROPN
admet-387	284	7	,	,	PUNCT
admet-387	284	8	t.	t.	PROPN
admet-387	284	9	komori	komori	PROPN
admet-387	284	10	,	,	PUNCT
admet-387	284	11	t.r	t.r	PROPN
admet-387	284	12	.	.	PROPN
admet-387	284	13	taylor	taylor	PROPN
admet-387	284	14	,	,	PUNCT
admet-387	284	15	d.	d.	PROPN
admet-387	284	16	stryke	stryke	PROPN
admet-387	284	17	,	,	PUNCT
admet-387	284	18	m.	m.	NOUN
admet-387	284	19	kawamoto	kawamoto	NOUN
admet-387	284	20	,	,	PUNCT
admet-387	284	21	s.j	s.j	PROPN
admet-387	284	22	.	.	PROPN
admet-387	284	23	johns	johns	PROPN
admet-387	284	24	,	,	PUNCT
admet-387	284	25	e.j	e.j	PROPN
admet-387	284	26	.	.	PROPN
admet-387	284	27	carlson	carlson	PROPN
admet-387	284	28	,	,	PUNCT
admet-387	284	29	t.e	t.e	PROPN
admet-387	284	30	.	.	PROPN
admet-387	284	31	ferrin	ferrin	PROPN
admet-387	284	32	,	,	PUNCT
admet-387	284	33	k.m	k.m	PROPN
admet-387	284	34	.	.	PROPN
admet-387	284	35	giacomini	giacomini	PROPN
admet-387	284	36	,	,	PUNCT
admet-387	284	37	american	american	ADJ
admet-387	284	38	journal	journal	PROPN
admet-387	284	39	of	of	ADP
admet-387	284	40	physiology	physiology	NOUN
admet-387	284	41	.	.	PUNCT
admet-387	285	1	renal	renal	ADJ
admet-387	285	2	physiology	physiology	NOUN
admet-387	285	3	299	299	NUM
admet-387	285	4	(	(	PUNCT
admet-387	285	5	2010	2010	NUM
admet-387	285	6	)	)	PUNCT
admet-387	285	7	f767	f767	PROPN
admet-387	285	8	-	-	PUNCT
admet-387	285	9	775	775	NUM
admet-387	285	10	.	.	PUNCT
admet-387	286	1	[	[	X
admet-387	286	2	25	25	NUM
admet-387	286	3	]	]	X
admet-387	286	4	y.	y.	PROPN
admet-387	286	5	hagos	hagos	PROPN
admet-387	286	6	,	,	PUNCT
admet-387	286	7	d.	d.	PROPN
admet-387	286	8	stein	stein	PROPN
admet-387	286	9	,	,	PUNCT
admet-387	286	10	b.	b.	PROPN
admet-387	286	11	ugele	ugele	PROPN
admet-387	286	12	,	,	PUNCT
admet-387	286	13	g.	g.	PROPN
admet-387	286	14	burckhardt	burckhardt	PROPN
admet-387	286	15	,	,	PUNCT
admet-387	286	16	a.	a.	NOUN
admet-387	286	17	bahn	bahn	NOUN
admet-387	286	18	,	,	PUNCT
admet-387	286	19	journal	journal	NOUN
admet-387	286	20	of	of	ADP
admet-387	286	21	the	the	DET
admet-387	286	22	american	american	ADJ
admet-387	286	23	society	society	NOUN
admet-387	286	24	of	of	ADP
admet-387	286	25	nephrology	nephrology	NOUN
admet-387	286	26	:	:	PUNCT
admet-387	286	27	jasn	jasn	NOUN
admet-387	286	28	18	18	NUM
admet-387	286	29	(	(	PUNCT
admet-387	286	30	2007	2007	NUM
admet-387	286	31	)	)	PUNCT
admet-387	286	32	430	430	NUM
admet-387	286	33	-	-	SYM
admet-387	286	34	439	439	NUM
admet-387	286	35	.	.	PUNCT
admet-387	287	1	[	[	X
admet-387	287	2	26	26	NUM
admet-387	287	3	]	]	X
admet-387	287	4	m.a	m.a	PROPN
admet-387	287	5	.	.	PROPN
admet-387	287	6	mcadams	mcadams	PROPN
admet-387	287	7	-	-	PUNCT
admet-387	287	8	demarco	demarco	PROPN
admet-387	287	9	,	,	PUNCT
admet-387	287	10	j.w	j.w	PROPN
admet-387	287	11	.	.	PROPN
admet-387	287	12	maynard	maynard	PROPN
admet-387	287	13	,	,	PUNCT
admet-387	287	14	a.n	a.n	PROPN
admet-387	287	15	.	.	PROPN
admet-387	287	16	baer	baer	PROPN
admet-387	287	17	,	,	PUNCT
admet-387	287	18	l.w	l.w	PROPN
admet-387	287	19	.	.	PROPN
admet-387	287	20	kao	kao	PROPN
admet-387	287	21	,	,	PUNCT
admet-387	287	22	a.	a.	NOUN
admet-387	287	23	kottgen	kottgen	PROPN
admet-387	287	24	,	,	PUNCT
admet-387	287	25	j.	j.	PROPN
admet-387	287	26	coresh	coresh	PROPN
admet-387	287	27	,	,	PUNCT
admet-387	287	28	annals	annal	NOUN
admet-387	287	29	of	of	ADP
admet-387	287	30	the	the	DET
admet-387	287	31	rheumatic	rheumatic	ADJ
admet-387	287	32	diseases	disease	NOUN
admet-387	287	33	72	72	NUM
admet-387	287	34	(	(	PUNCT
admet-387	287	35	2013	2013	NUM
admet-387	287	36	)	)	PUNCT
admet-387	287	37	701	701	NUM
admet-387	287	38	-	-	SYM
admet-387	287	39	706	706	NUM
admet-387	287	40	.	.	PUNCT
admet-387	288	1	[	[	X
admet-387	288	2	27	27	NUM
admet-387	288	3	]	]	X
admet-387	288	4	y.	y.	PROPN
admet-387	288	5	bao	bao	PROPN
admet-387	288	6	,	,	PUNCT
admet-387	288	7	g.	g.	PROPN
admet-387	288	8	curhan	curhan	PROPN
admet-387	288	9	,	,	PUNCT
admet-387	288	10	t.	t.	PROPN
admet-387	288	11	merriman	merriman	PROPN
admet-387	288	12	,	,	PUNCT
admet-387	288	13	r.	r.	PROPN
admet-387	288	14	plenge	plenge	PROPN
admet-387	288	15	,	,	PUNCT
admet-387	288	16	p.	p.	NOUN
admet-387	288	17	kraft	kraft	PROPN
admet-387	288	18	,	,	PUNCT
admet-387	288	19	h.k	h.k	PROPN
admet-387	288	20	.	.	PROPN
admet-387	288	21	choi	choi	PROPN
admet-387	288	22	,	,	PUNCT
admet-387	288	23	annals	annal	NOUN
admet-387	288	24	of	of	ADP
admet-387	288	25	the	the	DET
admet-387	288	26	rheumatic	rheumatic	ADJ
admet-387	288	27	diseases	disease	NOUN
admet-387	288	28	74	74	NUM
admet-387	288	29	(	(	PUNCT
admet-387	288	30	2015	2015	NUM
admet-387	288	31	)	)	PUNCT
admet-387	288	32	1394	1394	NUM
admet-387	288	33	-	-	SYM
admet-387	288	34	1398	1398	NUM
admet-387	288	35	.	.	PUNCT
admet-387	289	1	[	[	X
admet-387	289	2	28	28	NUM
admet-387	289	3	]	]	X
admet-387	289	4	a.	a.	NOUN
admet-387	289	5	bahn	bahn	NOUN
admet-387	289	6	,	,	PUNCT
admet-387	289	7	y.	y.	PROPN
admet-387	289	8	hagos	hagos	PROPN
admet-387	289	9	,	,	PUNCT
admet-387	289	10	s.	s.	PROPN
admet-387	289	11	reuter	reuter	PROPN
admet-387	289	12	,	,	PUNCT
admet-387	289	13	d.	d.	PROPN
admet-387	289	14	balen	balen	PROPN
admet-387	289	15	,	,	PUNCT
admet-387	289	16	h.	h.	PROPN
admet-387	289	17	brzica	brzica	PROPN
admet-387	289	18	,	,	PUNCT
admet-387	289	19	w.	w.	PROPN
admet-387	289	20	krick	krick	PROPN
admet-387	289	21	,	,	PUNCT
admet-387	289	22	b.c	b.c	PROPN
admet-387	289	23	.	.	PROPN
admet-387	289	24	burckhardt	burckhardt	PROPN
admet-387	289	25	,	,	PUNCT
admet-387	289	26	i.	i.	PROPN
admet-387	289	27	sabolic	sabolic	PROPN
admet-387	289	28	,	,	PUNCT
admet-387	289	29	g.	g.	PROPN
admet-387	289	30	burckhardt	burckhardt	PROPN
admet-387	289	31	,	,	PUNCT
admet-387	289	32	the	the	DET
admet-387	289	33	journal	journal	NOUN
admet-387	289	34	of	of	ADP
admet-387	289	35	biological	biological	ADJ
admet-387	289	36	chemistry	chemistry	NOUN
admet-387	289	37	283	283	NUM
admet-387	289	38	(	(	PUNCT
admet-387	289	39	2008	2008	NUM
admet-387	289	40	)	)	PUNCT
admet-387	289	41	16332	16332	NUM
admet-387	289	42	-	-	SYM
admet-387	289	43	16341	16341	NUM
admet-387	289	44	.	.	PUNCT
admet-387	290	1	[	[	X
admet-387	290	2	29	29	NUM
admet-387	290	3	]	]	X
admet-387	290	4	l.	l.	PROPN
admet-387	290	5	fagerberg	fagerberg	PROPN
admet-387	290	6	,	,	PUNCT
admet-387	290	7	b.m	b.m	PROPN
admet-387	290	8	.	.	PROPN
admet-387	290	9	hallstrom	hallstrom	NOUN
admet-387	290	10	,	,	PUNCT
admet-387	290	11	p.	p.	NOUN
admet-387	290	12	oksvold	oksvold	NOUN
admet-387	290	13	,	,	PUNCT
admet-387	290	14	c.	c.	PROPN
admet-387	290	15	kampf	kampf	PROPN
admet-387	290	16	,	,	PUNCT
admet-387	290	17	d.	d.	PROPN
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admet-387	290	19	,	,	PUNCT
admet-387	290	20	j.	j.	PROPN
admet-387	290	21	odeberg	odeberg	PROPN
admet-387	290	22	,	,	PUNCT
admet-387	290	23	et	et	PROPN
admet-387	290	24	al	al	PROPN
admet-387	290	25	.	.	PROPN
admet-387	291	1	molecular	molecular	ADJ
admet-387	291	2	&	&	CCONJ
admet-387	291	3	cellular	cellular	ADJ
admet-387	291	4	proteomics	proteomic	NOUN
admet-387	291	5	:	:	PUNCT
admet-387	291	6	mcp	mcp	PROPN
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admet-387	291	8	(	(	PUNCT
admet-387	291	9	2014	2014	NUM
admet-387	291	10	)	)	PUNCT
admet-387	291	11	397	397	NUM
admet-387	291	12	-	-	SYM
admet-387	291	13	406	406	NUM
admet-387	291	14	.	.	PUNCT
admet-387	292	1	[	[	X
admet-387	292	2	30	30	NUM
admet-387	292	3	]	]	X
admet-387	292	4	c.	c.	PROPN
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admet-387	292	6	,	,	PUNCT
admet-387	292	7	c.	c.	PROPN
admet-387	292	8	fork	fork	PROPN
admet-387	292	9	,	,	PUNCT
admet-387	292	10	t.	t.	PROPN
admet-387	292	11	bauer	bauer	PROPN
admet-387	292	12	,	,	PUNCT
admet-387	292	13	s.	s.	PROPN
admet-387	292	14	golz	golz	PROPN
admet-387	292	15	,	,	PUNCT
admet-387	292	16	a.	a.	NOUN
admet-387	292	17	geerts	geerts	PROPN
admet-387	292	18	,	,	PUNCT
admet-387	292	19	e.	e.	PROPN
admet-387	292	20	schomig	schomig	PROPN
admet-387	292	21	,	,	PUNCT
admet-387	292	22	d.	d.	PROPN
admet-387	292	23	grundemann	grundemann	PROPN
admet-387	292	24	,	,	PUNCT
admet-387	292	25	the	the	DET
admet-387	292	26	biochemical	biochemical	ADJ
admet-387	292	27	journal	journal	NOUN
admet-387	292	28	457	457	NUM
admet-387	292	29	(	(	PUNCT
admet-387	292	30	2014	2014	NUM
admet-387	292	31	)	)	PUNCT
admet-387	292	32	243	243	NUM
admet-387	292	33	-	-	SYM
admet-387	292	34	251	251	NUM
admet-387	292	35	.	.	PUNCT
admet-387	293	1	[	[	X
admet-387	293	2	31	31	NUM
admet-387	293	3	]	]	X
admet-387	293	4	n.	n.	PROPN
admet-387	293	5	anzai	anzai	PROPN
admet-387	293	6	,	,	PUNCT
admet-387	293	7	h.	h.	PROPN
admet-387	293	8	miyazaki	miyazaki	PROPN
admet-387	293	9	,	,	PUNCT
admet-387	293	10	h.	h.	PROPN
admet-387	293	11	endou	endou	PROPN
admet-387	293	12	,	,	PUNCT
admet-387	293	13	seikagaku	seikagaku	PROPN
admet-387	293	14	.	.	PUNCT
admet-387	294	1	the	the	DET
admet-387	294	2	journal	journal	NOUN
admet-387	294	3	of	of	ADP
admet-387	294	4	japanese	japanese	ADJ
admet-387	294	5	biochemical	biochemical	ADJ
admet-387	294	6	society	society	NOUN
admet-387	294	7	76	76	NUM
admet-387	294	8	(	(	PUNCT
admet-387	294	9	2004	2004	NUM
admet-387	294	10	)	)	PUNCT
admet-387	294	11	101	101	NUM
admet-387	294	12	-	-	SYM
admet-387	294	13	110	110	NUM
admet-387	294	14	.	.	PUNCT
admet-387	295	1	[	[	X
admet-387	295	2	32	32	NUM
admet-387	295	3	]	]	PUNCT
admet-387	295	4	h.	h.	PROPN
admet-387	295	5	miyazaki	miyazaki	PROPN
admet-387	295	6	,	,	PUNCT
admet-387	295	7	n.	n.	PROPN
admet-387	295	8	anzai	anzai	PROPN
admet-387	295	9	,	,	PUNCT
admet-387	295	10	s.	s.	PROPN
admet-387	295	11	ekaratanawong	ekaratanawong	PROPN
admet-387	295	12	,	,	PUNCT
admet-387	295	13	t.	t.	NOUN
admet-387	295	14	sakata	sakata	PROPN
admet-387	295	15	,	,	PUNCT
admet-387	295	16	h.j	h.j	PROPN
admet-387	295	17	.	.	PROPN
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admet-387	295	19	,	,	PUNCT
admet-387	295	20	p.	p.	NOUN
admet-387	295	21	jutabha	jutabha	NOUN
admet-387	295	22	,	,	PUNCT
admet-387	295	23	t.	t.	NOUN
admet-387	295	24	hirata	hirata	NOUN
admet-387	295	25	,	,	PUNCT
admet-387	295	26	x.	x.	NOUN
admet-387	295	27	he	he	PRON
admet-387	295	28	,	,	PUNCT
admet-387	295	29	h.	h.	PROPN
admet-387	295	30	nonoguchi	nonoguchi	PROPN
admet-387	295	31	,	,	PUNCT
admet-387	295	32	k.	k.	PROPN
admet-387	295	33	tomita	tomita	PROPN
admet-387	295	34	,	,	PUNCT
admet-387	295	35	y.	y.	PROPN
admet-387	295	36	kanai	kanai	PROPN
admet-387	295	37	,	,	PUNCT
admet-387	295	38	h.	h.	PROPN
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admet-387	295	40	,	,	PUNCT
admet-387	295	41	journal	journal	NOUN
admet-387	295	42	of	of	ADP
admet-387	295	43	the	the	DET
admet-387	295	44	american	american	ADJ
admet-387	295	45	society	society	NOUN
admet-387	295	46	of	of	ADP
admet-387	295	47	nephrology	nephrology	NOUN
admet-387	295	48	:	:	PUNCT
admet-387	295	49	jasn	jasn	VERB
admet-387	295	50	16	16	NUM
admet-387	295	51	(	(	PUNCT
admet-387	295	52	2005	2005	NUM
admet-387	295	53	)	)	PUNCT
admet-387	295	54	3498	3498	NUM
admet-387	295	55	-	-	SYM
admet-387	295	56	3506	3506	NUM
admet-387	295	57	.	.	PUNCT
admet-387	296	1	[	[	X
admet-387	296	2	33	33	NUM
admet-387	296	3	]	]	X
admet-387	296	4	y.	y.	PROPN
admet-387	296	5	kanai	kanai	PROPN
admet-387	296	6	,	,	PUNCT
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admet-387	296	9	.	.	PUNCT
admet-387	297	1	japanese	japanese	ADJ
admet-387	297	2	journal	journal	PROPN
admet-387	297	3	of	of	ADP
admet-387	297	4	clinical	clinical	ADJ
admet-387	297	5	medicine	medicine	NOUN
admet-387	297	6	66	66	NUM
admet-387	297	7	(	(	PUNCT
admet-387	297	8	2008	2008	NUM
admet-387	297	9	)	)	PUNCT
admet-387	297	10	659	659	NUM
admet-387	297	11	-	-	SYM
admet-387	297	12	666	666	NUM
admet-387	297	13	.	.	PUNCT
admet-387	298	1	[	[	X
admet-387	298	2	34	34	NUM
admet-387	298	3	]	]	SYM
admet-387	298	4	s.m	s.m	PROPN
admet-387	298	5	.	.	PROPN
admet-387	298	6	gisler	gisler	PROPN
admet-387	298	7	,	,	PUNCT
admet-387	298	8	s.	s.	PROPN
admet-387	298	9	pribanic	pribanic	PROPN
admet-387	298	10	,	,	PUNCT
admet-387	298	11	d.	d.	PROPN
admet-387	298	12	bacic	bacic	NOUN
admet-387	298	13	,	,	PUNCT
admet-387	298	14	p.	p.	NOUN
admet-387	298	15	forrer	forrer	PROPN
admet-387	298	16	,	,	PUNCT
admet-387	298	17	a.	a.	PROPN
admet-387	298	18	gantenbein	gantenbein	PROPN
admet-387	298	19	,	,	PUNCT
admet-387	298	20	l.a	l.a	PROPN
admet-387	298	21	.	.	PROPN
admet-387	298	22	sabourin	sabourin	PROPN
admet-387	298	23	,	,	PUNCT
admet-387	298	24	a.	a.	PROPN
admet-387	298	25	tsuji	tsuji	PROPN
admet-387	298	26	,	,	PUNCT
admet-387	298	27	z.s	z.s	PROPN
admet-387	298	28	.	.	PROPN
admet-387	298	29	zhao	zhao	PROPN
admet-387	298	30	,	,	PUNCT
admet-387	298	31	e.	e.	PROPN
admet-387	298	32	manser	manser	PROPN
admet-387	298	33	,	,	PUNCT
admet-387	298	34	j.	j.	PROPN
admet-387	298	35	biber	biber	PROPN
admet-387	298	36	,	,	PUNCT
admet-387	298	37	h.	h.	PROPN
admet-387	298	38	murer	murer	PROPN
admet-387	298	39	,	,	PUNCT
admet-387	298	40	kidney	kidney	NOUN
admet-387	298	41	international	international	ADJ
admet-387	298	42	64	64	NUM
admet-387	298	43	(	(	PUNCT
admet-387	298	44	2003	2003	NUM
admet-387	298	45	)	)	PUNCT
admet-387	298	46	1733	1733	NUM
admet-387	298	47	-	-	SYM
admet-387	298	48	1745	1745	NUM
admet-387	298	49	.	.	PUNCT
admet-387	299	1	[	[	X
admet-387	299	2	35	35	NUM
admet-387	299	3	]	]	X
admet-387	299	4	p.	p.	NOUN
admet-387	299	5	jutabha	jutabha	NOUN
admet-387	299	6	,	,	PUNCT
admet-387	299	7	n.	n.	PROPN
admet-387	299	8	anzai	anzai	PROPN
admet-387	299	9	,	,	PUNCT
admet-387	299	10	k.	k.	PROPN
admet-387	299	11	hayashi	hayashi	PROPN
admet-387	299	12	,	,	PUNCT
admet-387	299	13	m.	m.	NOUN
admet-387	299	14	domae	domae	PROPN
admet-387	299	15	,	,	PUNCT
admet-387	299	16	k.	k.	PROPN
admet-387	299	17	uchida	uchida	PROPN
admet-387	299	18	,	,	PUNCT
admet-387	299	19	h.	h.	PROPN
admet-387	299	20	endou	endou	PROPN
admet-387	299	21	,	,	PUNCT
admet-387	299	22	h.	h.	PROPN
admet-387	299	23	sakurai	sakurai	PROPN
admet-387	299	24	,	,	PUNCT
admet-387	299	25	journal	journal	NOUN
admet-387	299	26	of	of	ADP
admet-387	299	27	pharmacological	pharmacological	ADJ
admet-387	299	28	sciences	science	NOUN
admet-387	299	29	116	116	NUM
admet-387	299	30	(	(	PUNCT
admet-387	299	31	2011	2011	NUM
admet-387	299	32	)	)	PUNCT
admet-387	299	33	392	392	NUM
admet-387	299	34	-	-	SYM
admet-387	299	35	396	396	NUM
admet-387	299	36	.	.	PUNCT
admet-387	300	1	[	[	X
admet-387	300	2	36	36	NUM
admet-387	300	3	]	]	X
admet-387	300	4	o.	o.	PROPN
admet-387	300	5	kocher	kocher	PROPN
admet-387	300	6	,	,	PUNCT
admet-387	300	7	n.	n.	PROPN
admet-387	300	8	comella	comella	PROPN
admet-387	300	9	,	,	PUNCT
admet-387	300	10	a.	a.	NOUN
admet-387	300	11	gilchrist	gilchrist	PROPN
admet-387	300	12	,	,	PUNCT
admet-387	300	13	r.	r.	PROPN
admet-387	300	14	pal	pal	PROPN
admet-387	300	15	,	,	PUNCT
admet-387	300	16	k.	k.	PROPN
admet-387	300	17	tognazzi	tognazzi	PROPN
admet-387	300	18	,	,	PUNCT
admet-387	300	19	l.f	l.f	PROPN
admet-387	300	20	.	.	PROPN
admet-387	300	21	brown	brown	PROPN
admet-387	300	22	,	,	PUNCT
admet-387	300	23	j.h	j.h	PROPN
admet-387	300	24	.	.	PROPN
admet-387	300	25	knoll	knoll	PROPN
admet-387	300	26	,	,	PUNCT
admet-387	300	27	laboratory	laboratory	NOUN
admet-387	300	28	investigation	investigation	NOUN
admet-387	300	29	;	;	PUNCT
admet-387	300	30	a	a	DET
admet-387	300	31	journal	journal	NOUN
admet-387	300	32	of	of	ADP
admet-387	300	33	technical	technical	ADJ
admet-387	300	34	methods	method	NOUN
admet-387	300	35	and	and	CCONJ
admet-387	300	36	pathology	pathology	NOUN
admet-387	300	37	79	79	NUM
admet-387	300	38	(	(	PUNCT
admet-387	300	39	1999	1999	NUM
admet-387	300	40	)	)	PUNCT
admet-387	300	41	1161	1161	NUM
admet-387	300	42	-	-	SYM
admet-387	300	43	1170	1170	NUM
admet-387	300	44	.	.	PUNCT
admet-387	301	1	[	[	X
admet-387	301	2	37	37	NUM
admet-387	301	3	]	]	PUNCT
admet-387	301	4	j.	j.	PROPN
admet-387	301	5	park	park	PROPN
admet-387	301	6	,	,	PUNCT
admet-387	301	7	j.o	j.o	PROPN
admet-387	301	8	.	.	PROPN
admet-387	301	9	kwak	kwak	PROPN
admet-387	301	10	,	,	PUNCT
admet-387	301	11	b.	b.	PROPN
admet-387	301	12	riederer	riederer	PROPN
admet-387	301	13	,	,	PUNCT
admet-387	301	14	u.	u.	NOUN
admet-387	301	15	seidler	seidler	PROPN
admet-387	301	16	,	,	PUNCT
admet-387	301	17	s.p	s.p	PROPN
admet-387	301	18	.	.	PROPN
admet-387	301	19	cole	cole	PROPN
admet-387	301	20	,	,	PUNCT
admet-387	301	21	h.j	h.j	PROPN
admet-387	301	22	.	.	PROPN
admet-387	301	23	lee	lee	PROPN
admet-387	301	24	,	,	PUNCT
admet-387	301	25	m.g	m.g	PROPN
admet-387	301	26	.	.	PROPN
admet-387	301	27	lee	lee	PROPN
admet-387	301	28	,	,	PUNCT
admet-387	301	29	journal	journal	NOUN
admet-387	301	30	of	of	ADP
admet-387	301	31	the	the	DET
admet-387	301	32	american	american	ADJ
admet-387	301	33	society	society	NOUN
admet-387	301	34	of	of	ADP
admet-387	301	35	nephrology	nephrology	NOUN
admet-387	301	36	:	:	PUNCT
admet-387	301	37	jasn	jasn	NOUN
admet-387	301	38	25	25	NUM
admet-387	301	39	(	(	PUNCT
admet-387	301	40	2014	2014	NUM
admet-387	301	41	)	)	PUNCT
admet-387	301	42	726	726	NUM
admet-387	301	43	-	-	NUM
admet-387	301	44	736	736	NUM
admet-387	301	45	.	.	PUNCT
admet-387	302	1	[	[	X
admet-387	302	2	38	38	NUM
admet-387	302	3	]	]	X
admet-387	302	4	n.	n.	NOUN
admet-387	302	5	togawa	togawa	PROPN
admet-387	302	6	,	,	PUNCT
admet-387	302	7	t.	t.	PROPN
admet-387	302	8	miyaji	miyaji	PROPN
admet-387	302	9	,	,	PUNCT
admet-387	302	10	s.	s.	PROPN
admet-387	302	11	izawa	izawa	PROPN
admet-387	302	12	,	,	PUNCT
admet-387	302	13	h.	h.	PROPN
admet-387	302	14	omote	omote	PROPN
admet-387	302	15	,	,	PUNCT
admet-387	302	16	y.	y.	PROPN
admet-387	302	17	moriyama	moriyama	PROPN
admet-387	302	18	,	,	PUNCT
admet-387	302	19	american	american	ADJ
admet-387	302	20	journal	journal	PROPN
admet-387	302	21	of	of	ADP
admet-387	302	22	physiology	physiology	NOUN
admet-387	302	23	.	.	PUNCT
admet-387	303	1	cell	cell	NOUN
admet-387	303	2	physiology	physiology	NOUN
admet-387	303	3	302	302	NUM
admet-387	303	4	(	(	PUNCT
admet-387	303	5	2012	2012	NUM
admet-387	303	6	)	)	PUNCT
admet-387	303	7	c1652	c1652	NOUN
admet-387	303	8	-	-	NOUN
admet-387	303	9	1660	1660	NUM
admet-387	303	10	.	.	PUNCT
admet-387	304	1	[	[	X
admet-387	304	2	39	39	NUM
admet-387	304	3	]	]	PUNCT
admet-387	304	4	t.	t.	PROPN
admet-387	304	5	shimizu	shimizu	PROPN
admet-387	304	6	,	,	PUNCT
admet-387	304	7	t.	t.	NOUN
admet-387	304	8	sugiura	sugiura	NOUN
admet-387	304	9	,	,	PUNCT
admet-387	304	10	t.	t.	PROPN
admet-387	304	11	wakayama	wakayama	NOUN
admet-387	304	12	,	,	PUNCT
admet-387	304	13	a.	a.	PROPN
admet-387	304	14	kijima	kijima	PROPN
admet-387	304	15	,	,	PUNCT
admet-387	304	16	n.	n.	PROPN
admet-387	304	17	nakamichi	nakamichi	PROPN
admet-387	304	18	,	,	PUNCT
admet-387	304	19	s.	s.	PROPN
admet-387	304	20	iseki	iseki	PROPN
admet-387	304	21	,	,	PUNCT
admet-387	304	22	d.l	d.l	PROPN
admet-387	304	23	.	.	PROPN
admet-387	304	24	silver	silver	PROPN
admet-387	304	25	,	,	PUNCT
admet-387	304	26	y.	y.	PROPN
admet-387	304	27	kato	kato	PROPN
admet-387	304	28	,	,	PUNCT
admet-387	304	29	drug	drug	NOUN
admet-387	304	30	metabolism	metabolism	NOUN
admet-387	304	31	and	and	CCONJ
admet-387	304	32	disposition	disposition	NOUN
admet-387	304	33	:	:	PUNCT
admet-387	304	34	the	the	DET
admet-387	304	35	biological	biological	ADJ
admet-387	304	36	fate	fate	NOUN
admet-387	304	37	of	of	ADP
admet-387	304	38	chemicals	chemical	NOUN
admet-387	304	39	39	39	NUM
admet-387	304	40	(	(	PUNCT
admet-387	304	41	2011	2011	NUM
admet-387	304	42	)	)	PUNCT
admet-387	304	43	2148	2148	NUM
admet-387	304	44	-	-	SYM
admet-387	304	45	2154	2154	NUM
admet-387	304	46	.	.	PUNCT
admet-387	305	1	[	[	X
admet-387	305	2	40	40	NUM
admet-387	305	3	]	]	X
admet-387	305	4	s.k	s.k	PROPN
admet-387	305	5	.	.	PROPN
admet-387	305	6	nigam	nigam	PROPN
admet-387	305	7	,	,	PUNCT
admet-387	305	8	k.t	k.t	PROPN
admet-387	305	9	.	.	PROPN
admet-387	305	10	bush	bush	PROPN
admet-387	305	11	,	,	PUNCT
admet-387	305	12	g.	g.	PROPN
admet-387	305	13	martovetsky	martovetsky	PROPN
admet-387	305	14	,	,	PUNCT
admet-387	305	15	s.y	s.y	PROPN
admet-387	305	16	.	.	PROPN
admet-387	305	17	ahn	ahn	PROPN
admet-387	305	18	,	,	PUNCT
admet-387	305	19	h.c	h.c	PROPN
admet-387	305	20	.	.	PUNCT
admet-387	305	21	liu	liu	PROPN
admet-387	305	22	,	,	PUNCT
admet-387	305	23	e.	e.	PROPN
admet-387	305	24	richard	richard	PROPN
admet-387	305	25	,	,	PUNCT
admet-387	305	26	v.	v.	PROPN
admet-387	305	27	bhatnagar	bhatnagar	PROPN
admet-387	305	28	,	,	PUNCT
admet-387	305	29	w.	w.	PROPN
admet-387	305	30	wu	wu	PROPN
admet-387	305	31	,	,	PUNCT
admet-387	305	32	physiological	physiological	ADJ
admet-387	305	33	reviews	review	NOUN
admet-387	305	34	95	95	NUM
admet-387	305	35	(	(	PUNCT
admet-387	305	36	2015	2015	NUM
admet-387	305	37	)	)	PUNCT
admet-387	305	38	83	83	NUM
admet-387	305	39	-	-	SYM
admet-387	305	40	123	123	NUM
admet-387	305	41	.	.	PUNCT
admet-387	306	1	[	[	X
admet-387	306	2	41	41	NUM
admet-387	306	3	]	]	X
admet-387	306	4	p.k	p.k	PROPN
admet-387	306	5	.	.	PROPN
admet-387	306	6	tan	tan	PROPN
admet-387	306	7	,	,	PUNCT
admet-387	306	8	t.m	t.m	PROPN
admet-387	306	9	.	.	PROPN
admet-387	306	10	ostertag	ostertag	PROPN
admet-387	306	11	,	,	PUNCT
admet-387	306	12	j.n	j.n	PROPN
admet-387	306	13	.	.	PROPN
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admet-387	306	15	,	,	PUNCT
admet-387	306	16	scientific	scientific	ADJ
admet-387	306	17	reports	report	NOUN
admet-387	306	18	6	6	NUM
admet-387	306	19	(	(	PUNCT
admet-387	306	20	2016	2016	NUM
admet-387	306	21	)	)	PUNCT
admet-387	306	22	34995	34995	NUM
admet-387	306	23	.	.	PUNCT
admet-387	307	1	[	[	X
admet-387	307	2	42	42	NUM
admet-387	307	3	]	]	X
admet-387	307	4	j.	j.	PROPN
admet-387	307	5	miner	miner	PROPN
admet-387	307	6	,	,	PUNCT
admet-387	307	7	p.k	p.k	PROPN
admet-387	307	8	.	.	PROPN
admet-387	307	9	tan	tan	PROPN
admet-387	307	10	,	,	PUNCT
admet-387	307	11	d.	d.	PROPN
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admet-387	307	13	,	,	PUNCT
admet-387	307	14	s.	s.	PROPN
admet-387	307	15	liu	liu	PROPN
admet-387	307	16	,	,	PUNCT
admet-387	307	17	c.	c.	PROPN
admet-387	307	18	iverson	iverson	PROPN
admet-387	307	19	,	,	PUNCT
admet-387	307	20	p.	p.	PROPN
admet-387	307	21	nanavati	nanavati	PROPN
admet-387	307	22	,	,	PUNCT
admet-387	307	23	d.t	d.t	PROPN
admet-387	307	24	.	.	PROPN
admet-387	307	25	hagerty	hagerty	PROPN
admet-387	307	26	,	,	PUNCT
admet-387	307	27	k.	k.	PROPN
admet-387	307	28	manhard	manhard	PROPN
admet-387	307	29	,	,	PUNCT
admet-387	307	30	z.	z.	PROPN
admet-387	307	31	shen	shen	PROPN
admet-387	307	32	,	,	PUNCT
admet-387	307	33	j.l	j.l	PROPN
admet-387	307	34	.	.	PROPN
admet-387	307	35	girardet	girardet	PROPN
admet-387	307	36	,	,	PUNCT
admet-387	307	37	l.t	l.t	PROPN
admet-387	307	38	.	.	PROPN
admet-387	307	39	yeh	yeh	PROPN
admet-387	307	40	,	,	PUNCT
admet-387	307	41	r.	r.	PROPN
admet-387	307	42	terkeltaub	terkeltaub	PROPN
admet-387	307	43	,	,	PUNCT
admet-387	307	44	b.	b.	PROPN
admet-387	307	45	quart	quart	PROPN
admet-387	307	46	,	,	PUNCT
admet-387	307	47	arthritis	arthritis	NOUN
admet-387	307	48	research	research	NOUN
admet-387	307	49	&	&	CCONJ
admet-387	307	50	therapy	therapy	PROPN
admet-387	307	51	18	18	NUM
admet-387	307	52	(	(	PUNCT
admet-387	307	53	2016	2016	NUM
admet-387	307	54	)	)	PUNCT
admet-387	307	55	214	214	NUM
admet-387	307	56	.	.	PUNCT
admet-387	308	1	[	[	X
admet-387	308	2	43	43	NUM
admet-387	308	3	]	]	PUNCT
admet-387	308	4	z.	z.	PROPN
admet-387	308	5	shen	shen	PROPN
admet-387	308	6	,	,	PUNCT
admet-387	308	7	c.	c.	PROPN
admet-387	308	8	rowlings	rowling	NOUN
admet-387	308	9	,	,	PUNCT
admet-387	308	10	b.	b.	PROPN
admet-387	308	11	kerr	kerr	PROPN
admet-387	308	12	,	,	PUNCT
admet-387	308	13	v.	v.	PROPN
admet-387	308	14	hingorani	hingorani	PROPN
admet-387	308	15	,	,	PUNCT
admet-387	308	16	k.	k.	PROPN
admet-387	308	17	manhard	manhard	PROPN
admet-387	308	18	,	,	PUNCT
admet-387	308	19	b.	b.	PROPN
admet-387	308	20	quart	quart	PROPN
admet-387	308	21	,	,	PUNCT
admet-387	308	22	l.t	l.t	PROPN
admet-387	308	23	.	.	PROPN
admet-387	308	24	yeh	yeh	PROPN
admet-387	308	25	,	,	PUNCT
admet-387	308	26	c.	c.	PROPN
admet-387	308	27	storgard	storgard	PROPN
admet-387	308	28	,	,	PUNCT
admet-387	308	29	drug	drug	NOUN
admet-387	308	30	design	design	NOUN
admet-387	308	31	,	,	PUNCT
admet-387	308	32	development	development	NOUN
admet-387	308	33	and	and	CCONJ
admet-387	308	34	therapy	therapy	NOUN
admet-387	308	35	9	9	NUM
admet-387	308	36	(	(	PUNCT
admet-387	308	37	2015	2015	NUM
admet-387	308	38	)	)	PUNCT
admet-387	308	39	3423	3423	NUM
admet-387	308	40	-	-	SYM
admet-387	308	41	3434	3434	NUM
admet-387	308	42	.	.	PUNCT
admet-387	309	1	tan	tan	PROPN
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admet-387	309	3	miner	miner	PROPN
admet-387	309	4	admet	admet	PROPN
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admet-387	309	6	dmpk	dmpk	PROPN
admet-387	309	7	5(2	5(2	NUM
admet-387	309	8	)	)	PUNCT
admet-387	309	9	(	(	PUNCT
admet-387	309	10	2017	2017	NUM
admet-387	309	11	)	)	PUNCT
admet-387	309	12	59	59	NUM
admet-387	309	13	-	-	SYM
admet-387	309	14	74	74	NUM
admet-387	309	15	72	72	NUM
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admet-387	309	17	44	44	NUM
admet-387	309	18	]	]	PUNCT
admet-387	309	19	p.	p.	NOUN
admet-387	309	20	jutabha	jutabha	NOUN
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admet-387	309	22	n.	n.	PROPN
admet-387	309	23	anzai	anzai	NOUN
admet-387	309	24	,	,	PUNCT
admet-387	309	25	t.	t.	PROPN
admet-387	309	26	kimura	kimura	NOUN
admet-387	309	27	,	,	PUNCT
admet-387	309	28	a.	a.	PROPN
admet-387	309	29	taniguchi	taniguchi	PROPN
admet-387	309	30	,	,	PUNCT
admet-387	309	31	w.	w.	PROPN
admet-387	309	32	urano	urano	PROPN
admet-387	309	33	,	,	PUNCT
admet-387	309	34	h.	h.	PROPN
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admet-387	309	36	,	,	PUNCT
admet-387	309	37	h.	h.	PROPN
admet-387	309	38	endou	endou	PROPN
admet-387	309	39	,	,	PUNCT
admet-387	309	40	h.	h.	PROPN
admet-387	309	41	sakurai	sakurai	PROPN
admet-387	309	42	,	,	PUNCT
admet-387	309	43	journal	journal	NOUN
admet-387	309	44	of	of	ADP
admet-387	309	45	pharmacological	pharmacological	ADJ
admet-387	309	46	sciences	science	NOUN
admet-387	309	47	115	115	NUM
admet-387	309	48	(	(	PUNCT
admet-387	309	49	2011	2011	NUM
admet-387	309	50	)	)	PUNCT
admet-387	309	51	249	249	NUM
admet-387	309	52	-	-	SYM
admet-387	309	53	253	253	NUM
admet-387	309	54	.	.	PUNCT
admet-387	310	1	[	[	X
admet-387	310	2	45	45	NUM
admet-387	310	3	]	]	PUNCT
admet-387	310	4	p.	p.	NOUN
admet-387	310	5	jutabha	jutabha	NOUN
admet-387	310	6	,	,	PUNCT
admet-387	310	7	n.	n.	PROPN
admet-387	310	8	anzai	anzai	PROPN
admet-387	310	9	,	,	PUNCT
admet-387	310	10	m.f	m.f	PROPN
admet-387	310	11	.	.	PROPN
admet-387	310	12	wempe	wempe	PROPN
admet-387	310	13	,	,	PUNCT
admet-387	310	14	s.	s.	PROPN
admet-387	310	15	wakui	wakui	PROPN
admet-387	310	16	,	,	PUNCT
admet-387	310	17	h.	h.	PROPN
admet-387	310	18	endou	endou	NOUN
admet-387	310	19	,	,	PUNCT
admet-387	310	20	h.	h.	PROPN
admet-387	310	21	sakurai	sakurai	PROPN
admet-387	310	22	,	,	PUNCT
admet-387	310	23	nucleosides	nucleoside	NOUN
admet-387	310	24	,	,	PUNCT
admet-387	310	25	nucleotides	nucleotide	NOUN
admet-387	310	26	&	&	CCONJ
admet-387	310	27	nucleic	nucleic	ADJ
admet-387	310	28	acids	acid	NOUN
admet-387	310	29	30	30	NUM
admet-387	310	30	(	(	PUNCT
admet-387	310	31	2011	2011	NUM
admet-387	310	32	)	)	PUNCT
admet-387	310	33	1302	1302	NUM
admet-387	310	34	-	-	SYM
admet-387	310	35	1311	1311	NUM
admet-387	310	36	.	.	PUNCT
admet-387	311	1	[	[	X
admet-387	311	2	46	46	NUM
admet-387	311	3	]	]	PUNCT
admet-387	311	4	t.	t.	PROPN
admet-387	311	5	chiba	chiba	PROPN
admet-387	311	6	,	,	PUNCT
admet-387	311	7	h.	h.	PROPN
admet-387	311	8	matsuo	matsuo	PROPN
admet-387	311	9	,	,	PUNCT
admet-387	311	10	y.	y.	PROPN
admet-387	311	11	kawamura	kawamura	PROPN
admet-387	311	12	,	,	PUNCT
admet-387	311	13	s.	s.	PROPN
admet-387	311	14	nagamori	nagamori	PROPN
admet-387	311	15	,	,	PUNCT
admet-387	311	16	t.	t.	PROPN
admet-387	311	17	nishiyama	nishiyama	PROPN
admet-387	311	18	,	,	PUNCT
admet-387	311	19	l.	l.	PROPN
admet-387	311	20	wei	wei	PROPN
admet-387	311	21	,	,	PUNCT
admet-387	311	22	et	et	PROPN
admet-387	311	23	al	al	PROPN
admet-387	311	24	.	.	PUNCT
admet-387	311	25	arthritis	arthritis	PROPN
admet-387	311	26	&	&	CCONJ
admet-387	311	27	rheumatology	rheumatology	PROPN
admet-387	311	28	67	67	NUM
admet-387	311	29	(	(	PUNCT
admet-387	311	30	2015	2015	NUM
admet-387	311	31	)	)	PUNCT
admet-387	311	32	281	281	NUM
admet-387	311	33	-	-	SYM
admet-387	311	34	287	287	NUM
admet-387	311	35	.	.	PUNCT
admet-387	312	1	[	[	X
admet-387	312	2	47	47	NUM
admet-387	312	3	]	]	PUNCT
admet-387	312	4	m.	m.	NOUN
admet-387	312	5	sakiyama	sakiyama	PROPN
admet-387	312	6	,	,	PUNCT
admet-387	312	7	h.	h.	PROPN
admet-387	312	8	matsuo	matsuo	PROPN
admet-387	312	9	,	,	PUNCT
admet-387	312	10	s.	s.	PROPN
admet-387	312	11	nagamori	nagamori	PROPN
admet-387	312	12	,	,	PUNCT
admet-387	312	13	w.	w.	PROPN
admet-387	312	14	ling	ling	PROPN
admet-387	312	15	,	,	PUNCT
admet-387	312	16	y.	y.	PROPN
admet-387	312	17	kawamura	kawamura	PROPN
admet-387	312	18	,	,	PUNCT
admet-387	312	19	a.	a.	NOUN
admet-387	312	20	nakayama	nakayama	PROPN
admet-387	312	21	,	,	PUNCT
admet-387	312	22	t.	t.	PROPN
admet-387	312	23	higashino	higashino	PROPN
admet-387	312	24	,	,	PUNCT
admet-387	312	25	t.	t.	PROPN
admet-387	312	26	chiba	chiba	PROPN
admet-387	312	27	,	,	PUNCT
admet-387	312	28	k.	k.	PROPN
admet-387	312	29	ichida	ichida	PROPN
admet-387	312	30	,	,	PUNCT
admet-387	312	31	y.	y.	PROPN
admet-387	312	32	kanai	kanai	PROPN
admet-387	312	33	,	,	PUNCT
admet-387	312	34	n.	n.	PROPN
admet-387	312	35	shinomiya	shinomiya	PROPN
admet-387	312	36	,	,	PUNCT
admet-387	312	37	nucleosides	nucleoside	NOUN
admet-387	312	38	,	,	PUNCT
admet-387	312	39	nucleotides	nucleotide	NOUN
admet-387	312	40	&	&	CCONJ
admet-387	312	41	nucleic	nucleic	ADJ
admet-387	312	42	acids	acid	NOUN
admet-387	312	43	35	35	NUM
admet-387	312	44	(	(	PUNCT
admet-387	312	45	2016	2016	NUM
admet-387	312	46	)	)	PUNCT
admet-387	312	47	536	536	NUM
admet-387	312	48	-	-	SYM
admet-387	312	49	542	542	NUM
admet-387	312	50	.	.	PUNCT
admet-387	313	1	[	[	X
admet-387	313	2	48	48	NUM
admet-387	313	3	]	]	SYM
admet-387	313	4	a.a	a.a	PROPN
admet-387	313	5	.	.	PROPN
admet-387	313	6	el	el	PROPN
admet-387	313	7	-	-	PUNCT
admet-387	313	8	sheikh	sheikh	PROPN
admet-387	313	9	,	,	PUNCT
admet-387	313	10	j.j	j.j	PROPN
admet-387	313	11	.	.	PROPN
admet-387	313	12	van	van	PROPN
admet-387	313	13	den	den	PROPN
admet-387	313	14	heuvel	heuvel	PROPN
admet-387	313	15	,	,	PUNCT
admet-387	313	16	j.b	j.b	PROPN
admet-387	313	17	.	.	PUNCT
admet-387	313	18	koenderink	koenderink	PROPN
admet-387	313	19	,	,	PUNCT
admet-387	313	20	f.g	f.g	PROPN
admet-387	313	21	.	.	PROPN
admet-387	313	22	russel	russel	PROPN
admet-387	313	23	,	,	PUNCT
admet-387	313	24	british	british	ADJ
admet-387	313	25	journal	journal	PROPN
admet-387	313	26	of	of	ADP
admet-387	313	27	pharmacology	pharmacology	NOUN
admet-387	313	28	155	155	NUM
admet-387	313	29	(	(	PUNCT
admet-387	313	30	2008	2008	NUM
admet-387	313	31	)	)	PUNCT
admet-387	313	32	1066	1066	NUM
admet-387	313	33	-	-	SYM
admet-387	313	34	1075	1075	NUM
admet-387	313	35	.	.	PUNCT
admet-387	314	1	[	[	X
admet-387	314	2	49	49	NUM
admet-387	314	3	]	]	X
admet-387	314	4	n.	n.	PROPN
admet-387	314	5	dalbeth	dalbeth	PROPN
admet-387	314	6	,	,	PUNCT
admet-387	314	7	m.e	m.e	PROPN
admet-387	314	8	.	.	PROPN
admet-387	314	9	house	house	PROPN
admet-387	314	10	,	,	PUNCT
admet-387	314	11	g.d	g.d	PROPN
admet-387	314	12	.	.	PROPN
admet-387	314	13	gamble	gamble	PROPN
admet-387	314	14	,	,	PUNCT
admet-387	314	15	b.	b.	PROPN
admet-387	314	16	pool	pool	NOUN
admet-387	314	17	,	,	PUNCT
admet-387	314	18	a.	a.	NOUN
admet-387	314	19	horne	horne	PROPN
admet-387	314	20	,	,	PUNCT
admet-387	314	21	l.	l.	PROPN
admet-387	314	22	purvis	purvis	PROPN
admet-387	314	23	,	,	PUNCT
admet-387	314	24	a.	a.	PROPN
admet-387	314	25	stewart	stewart	PROPN
admet-387	314	26	,	,	PUNCT
admet-387	314	27	m.	m.	NOUN
admet-387	314	28	merriman	merriman	PROPN
admet-387	314	29	,	,	PUNCT
admet-387	314	30	m.	m.	NOUN
admet-387	314	31	cadzow	cadzow	PROPN
admet-387	314	32	,	,	PUNCT
admet-387	314	33	a.	a.	PROPN
admet-387	314	34	phipps	phipps	PROPN
admet-387	314	35	-	-	PUNCT
admet-387	314	36	green	green	PROPN
admet-387	314	37	,	,	PUNCT
admet-387	314	38	t.r	t.r	PROPN
admet-387	314	39	.	.	PROPN
admet-387	314	40	merriman	merriman	PROPN
admet-387	314	41	,	,	PUNCT
admet-387	314	42	arthritis	arthritis	NOUN
admet-387	314	43	research	research	PROPN
admet-387	314	44	&	&	CCONJ
admet-387	314	45	therapy	therapy	PROPN
admet-387	314	46	16	16	NUM
admet-387	314	47	(	(	PUNCT
admet-387	314	48	2014	2014	NUM
admet-387	314	49	)	)	PUNCT
admet-387	314	50	r34	r34	NOUN
admet-387	314	51	.	.	PUNCT
admet-387	315	1	[	[	X
admet-387	315	2	50	50	NUM
admet-387	315	3	]	]	X
admet-387	315	4	p.k	p.k	PROPN
admet-387	315	5	.	.	PROPN
admet-387	315	6	tan	tan	PROPN
admet-387	315	7	,	,	PUNCT
admet-387	315	8	j.e	j.e	PROPN
admet-387	315	9	.	.	PROPN
admet-387	315	10	farrar	farrar	PROPN
admet-387	315	11	,	,	PUNCT
admet-387	315	12	e.a	e.a	PROPN
admet-387	315	13	.	.	PROPN
admet-387	315	14	gaucher	gaucher	PROPN
admet-387	315	15	,	,	PUNCT
admet-387	315	16	j.n	j.n	PROPN
admet-387	315	17	.	.	PROPN
admet-387	315	18	miner	miner	NOUN
admet-387	315	19	,	,	PUNCT
admet-387	315	20	molecular	molecular	ADJ
admet-387	315	21	biology	biology	NOUN
admet-387	315	22	and	and	CCONJ
admet-387	315	23	evolution	evolution	NOUN
admet-387	315	24	33	33	NUM
admet-387	315	25	(	(	PUNCT
admet-387	315	26	2016	2016	NUM
admet-387	315	27	)	)	PUNCT
admet-387	315	28	21932200	21932200	NUM
admet-387	315	29	.	.	PUNCT
admet-387	316	1	[	[	X
admet-387	316	2	51	51	NUM
admet-387	316	3	]	]	X
admet-387	316	4	r.j	r.j	PROPN
admet-387	316	5	.	.	PROPN
admet-387	316	6	johnson	johnson	PROPN
admet-387	316	7	,	,	PUNCT
admet-387	316	8	y.y	y.y	PROPN
admet-387	316	9	.	.	PROPN
admet-387	316	10	sautin	sautin	PROPN
admet-387	316	11	,	,	PUNCT
admet-387	316	12	w.j	w.j	PROPN
admet-387	316	13	.	.	PROPN
admet-387	316	14	oliver	oliver	PROPN
admet-387	316	15	,	,	PUNCT
admet-387	316	16	c.	c.	PROPN
admet-387	316	17	roncal	roncal	PROPN
admet-387	316	18	,	,	PUNCT
admet-387	316	19	w.	w.	PROPN
admet-387	316	20	mu	mu	PROPN
admet-387	316	21	,	,	PUNCT
admet-387	316	22	l.	l.	PROPN
admet-387	316	23	gabriela	gabriela	PROPN
admet-387	316	24	sanchez	sanchez	PROPN
admet-387	316	25	-	-	PUNCT
admet-387	316	26	lozada	lozada	PROPN
admet-387	316	27	,	,	PUNCT
admet-387	316	28	b.	b.	PROPN
admet-387	316	29	rodrigueziturbe	rodrigueziturbe	PROPN
admet-387	316	30	,	,	PUNCT
admet-387	316	31	t.	t.	PROPN
admet-387	316	32	nakagawa	nakagawa	PROPN
admet-387	316	33	,	,	PUNCT
admet-387	316	34	s.a	s.a	PROPN
admet-387	316	35	.	.	PROPN
admet-387	316	36	benner	benner	PROPN
admet-387	316	37	,	,	PUNCT
admet-387	316	38	j	j	PROPN
admet-387	316	39	comp	comp	PROPN
admet-387	316	40	physiol	physiol	PROPN
admet-387	316	41	b	b	PROPN
admet-387	316	42	179	179	NUM
admet-387	316	43	(	(	PUNCT
admet-387	316	44	2009	2009	NUM
admet-387	316	45	)	)	PUNCT
admet-387	316	46	67	67	NUM
admet-387	316	47	-	-	SYM
admet-387	316	48	76	76	NUM
admet-387	316	49	.	.	PUNCT
admet-387	317	1	[	[	X
admet-387	317	2	52	52	NUM
admet-387	317	3	]	]	X
admet-387	317	4	a.j	a.j	PROPN
admet-387	317	5	.	.	PROPN
admet-387	317	6	ahola	ahola	PROPN
admet-387	317	7	,	,	PUNCT
admet-387	317	8	n.	n.	PROPN
admet-387	317	9	sandholm	sandholm	PROPN
admet-387	317	10	,	,	PUNCT
admet-387	317	11	c.	c.	PROPN
admet-387	317	12	forsblom	forsblom	PROPN
admet-387	317	13	,	,	PUNCT
admet-387	317	14	v.	v.	ADP
admet-387	317	15	harjutsalo	harjutsalo	PROPN
admet-387	317	16	,	,	PUNCT
admet-387	317	17	e.	e.	PROPN
admet-387	317	18	dahlstrom	dahlstrom	PROPN
admet-387	317	19	,	,	PUNCT
admet-387	317	20	p.h	p.h	PROPN
admet-387	317	21	.	.	PROPN
admet-387	317	22	groop	groop	PROPN
admet-387	317	23	,	,	PUNCT
admet-387	317	24	g.	g.	PROPN
admet-387	317	25	finndiane	finndiane	PROPN
admet-387	317	26	study	study	PROPN
admet-387	317	27	,	,	PUNCT
admet-387	317	28	kidney	kidney	PROPN
admet-387	317	29	international	international	ADJ
admet-387	317	30	(	(	PUNCT
admet-387	317	31	2017	2017	NUM
admet-387	317	32	)	)	PUNCT
admet-387	317	33	.	.	PUNCT
admet-387	318	1	[	[	X
admet-387	318	2	53	53	NUM
admet-387	318	3	]	]	PUNCT
admet-387	318	4	i.	i.	PROPN
admet-387	318	5	sluijs	sluijs	PROPN
admet-387	318	6	,	,	PUNCT
admet-387	318	7	m.v	m.v	PROPN
admet-387	318	8	.	.	PROPN
admet-387	318	9	holmes	holmes	PROPN
admet-387	318	10	,	,	PUNCT
admet-387	318	11	y.t	y.t	PROPN
admet-387	318	12	.	.	PROPN
admet-387	318	13	van	van	PROPN
admet-387	318	14	der	der	PROPN
admet-387	318	15	schouw	schouw	PROPN
admet-387	318	16	,	,	PUNCT
admet-387	318	17	j.w	j.w	PROPN
admet-387	318	18	.	.	PROPN
admet-387	318	19	beulens	beulens	PROPN
admet-387	318	20	,	,	PUNCT
admet-387	318	21	f.w	f.w	PROPN
admet-387	318	22	.	.	PROPN
admet-387	318	23	asselbergs	asselbergs	PROPN
admet-387	318	24	,	,	PUNCT
admet-387	318	25	j.m	j.m	PROPN
admet-387	318	26	.	.	PROPN
admet-387	318	27	huerta	huerta	PROPN
admet-387	318	28	,	,	PUNCT
admet-387	318	29	et	et	PROPN
admet-387	318	30	al	al	PROPN
admet-387	318	31	.	.	PROPN
admet-387	319	1	diabetes	diabetes	NOUN
admet-387	319	2	64	64	NUM
admet-387	319	3	(	(	PUNCT
admet-387	319	4	2015	2015	NUM
admet-387	319	5	)	)	PUNCT
admet-387	319	6	3028	3028	NUM
admet-387	319	7	-	-	SYM
admet-387	319	8	3036	3036	NUM
admet-387	319	9	.	.	PUNCT
admet-387	320	1	[	[	X
admet-387	320	2	54	54	NUM
admet-387	320	3	]	]	X
admet-387	320	4	d.	d.	PROPN
admet-387	320	5	yan	yan	PROPN
admet-387	320	6	,	,	PUNCT
admet-387	320	7	j.	j.	PROPN
admet-387	320	8	wang	wang	PROPN
admet-387	320	9	,	,	PUNCT
admet-387	320	10	f.	f.	PROPN
admet-387	320	11	jiang	jiang	PROPN
admet-387	320	12	,	,	PUNCT
admet-387	320	13	r.	r.	PROPN
admet-387	320	14	zhang	zhang	PROPN
admet-387	320	15	,	,	PUNCT
admet-387	320	16	t.	t.	PROPN
admet-387	320	17	wang	wang	PROPN
admet-387	320	18	,	,	PUNCT
admet-387	320	19	s.	s.	PROPN
admet-387	320	20	wang	wang	PROPN
admet-387	320	21	,	,	PUNCT
admet-387	320	22	d.	d.	PROPN
admet-387	320	23	peng	peng	PROPN
admet-387	320	24	,	,	PUNCT
admet-387	320	25	z.	z.	PROPN
admet-387	320	26	he	he	PRON
admet-387	320	27	,	,	PUNCT
admet-387	320	28	h.	h.	PROPN
admet-387	320	29	chen	chen	PROPN
admet-387	320	30	,	,	PUNCT
admet-387	320	31	y.	y.	PROPN
admet-387	320	32	bao	bao	PROPN
admet-387	320	33	,	,	PUNCT
admet-387	320	34	c.	c.	PROPN
admet-387	320	35	hu	hu	PROPN
admet-387	320	36	,	,	PUNCT
admet-387	320	37	w.	w.	PROPN
admet-387	320	38	jia	jia	PROPN
admet-387	320	39	,	,	PUNCT
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admet-387	320	41	journal	journal	NOUN
admet-387	320	42	of	of	ADP
admet-387	320	43	cardiology	cardiology	NOUN
admet-387	320	44	214	214	NUM
admet-387	320	45	(	(	PUNCT
admet-387	320	46	2016	2016	NUM
admet-387	320	47	)	)	PUNCT
admet-387	320	48	194	194	NUM
admet-387	320	49	-	-	SYM
admet-387	320	50	199	199	NUM
admet-387	320	51	.	.	PUNCT
admet-387	321	1	[	[	X
admet-387	321	2	55	55	NUM
admet-387	321	3	]	]	X
admet-387	321	4	j.	j.	PROPN
admet-387	321	5	white	white	PROPN
admet-387	321	6	,	,	PUNCT
admet-387	321	7	r.	r.	PROPN
admet-387	321	8	sofat	sofat	PROPN
admet-387	321	9	,	,	PUNCT
admet-387	321	10	g.	g.	PROPN
admet-387	321	11	hemani	hemani	PROPN
admet-387	321	12	,	,	PUNCT
admet-387	321	13	t.	t.	NOUN
admet-387	321	14	shah	shah	PROPN
admet-387	321	15	,	,	PUNCT
admet-387	321	16	j.	j.	PROPN
admet-387	321	17	engmann	engmann	PROPN
admet-387	321	18	,	,	PUNCT
admet-387	321	19	c.	c.	PROPN
admet-387	321	20	dale	dale	PROPN
admet-387	321	21	,	,	PUNCT
admet-387	321	22	et	et	PROPN
admet-387	321	23	al	al	PROPN
admet-387	321	24	.	.	PUNCT
admet-387	322	1	the	the	DET
admet-387	322	2	lancet	lancet	PROPN
admet-387	322	3	.	.	PUNCT
admet-387	323	1	diabetes	diabetes	NOUN
admet-387	323	2	&	&	CCONJ
admet-387	323	3	endocrinology	endocrinology	PROPN
admet-387	323	4	4	4	NUM
admet-387	323	5	(	(	PUNCT
admet-387	323	6	2016	2016	NUM
admet-387	323	7	)	)	PUNCT
admet-387	323	8	327	327	NUM
admet-387	323	9	-	-	SYM
admet-387	323	10	336	336	NUM
admet-387	323	11	.	.	PUNCT
admet-387	324	1	[	[	X
admet-387	324	2	56	56	NUM
admet-387	324	3	]	]	PUNCT
admet-387	324	4	t.	t.	PROPN
admet-387	324	5	yamamoto	yamamoto	PROPN
admet-387	324	6	,	,	PUNCT
admet-387	324	7	h.	h.	PROPN
admet-387	324	8	yokoyama	yokoyama	PROPN
admet-387	324	9	,	,	PUNCT
admet-387	324	10	y.	y.	PROPN
admet-387	324	11	moriwaki	moriwaki	PROPN
admet-387	324	12	,	,	PUNCT
admet-387	324	13	s.	s.	PROPN
admet-387	324	14	takahashi	takahashi	PROPN
admet-387	324	15	,	,	PUNCT
admet-387	324	16	m.	m.	PROPN
admet-387	324	17	suda	suda	PROPN
admet-387	324	18	,	,	PUNCT
admet-387	324	19	t.	t.	PROPN
admet-387	324	20	hada	hada	PROPN
admet-387	324	21	,	,	PUNCT
admet-387	324	22	k.	k.	PROPN
admet-387	324	23	higashino	higashino	PROPN
admet-387	324	24	,	,	PUNCT
admet-387	324	25	european	european	PROPN
admet-387	324	26	journal	journal	PROPN
admet-387	324	27	of	of	ADP
admet-387	324	28	clinical	clinical	ADJ
admet-387	324	29	nutrition	nutrition	NOUN
admet-387	324	30	44	44	NUM
admet-387	324	31	(	(	PUNCT
admet-387	324	32	1990	1990	NUM
admet-387	324	33	)	)	PUNCT
admet-387	324	34	659	659	NUM
admet-387	324	35	-	-	SYM
admet-387	324	36	664	664	NUM
admet-387	324	37	.	.	PUNCT
admet-387	325	1	[	[	X
admet-387	325	2	57	57	NUM
admet-387	325	3	]	]	X
admet-387	325	4	t.r	t.r	PROPN
admet-387	325	5	.	.	PROPN
admet-387	325	6	merriman	merriman	PROPN
admet-387	325	7	,	,	PUNCT
admet-387	325	8	arthritis	arthritis	NOUN
admet-387	325	9	research	research	NOUN
admet-387	325	10	&	&	CCONJ
admet-387	325	11	therapy	therapy	PROPN
admet-387	325	12	17	17	NUM
admet-387	325	13	(	(	PUNCT
admet-387	325	14	2015	2015	NUM
admet-387	325	15	)	)	PUNCT
admet-387	325	16	98	98	NUM
admet-387	325	17	.	.	PUNCT
admet-387	326	1	[	[	X
admet-387	326	2	58	58	NUM
admet-387	326	3	]	]	PUNCT
admet-387	326	4	t.	t.	PROPN
admet-387	326	5	dan	dan	PROPN
admet-387	326	6	,	,	PUNCT
admet-387	326	7	h.	h.	PROPN
admet-387	326	8	koga	koga	PROPN
admet-387	326	9	,	,	PUNCT
admet-387	326	10	european	european	PROPN
admet-387	326	11	journal	journal	PROPN
admet-387	326	12	of	of	ADP
admet-387	326	13	pharmacology	pharmacology	NOUN
admet-387	326	14	187	187	NUM
admet-387	326	15	(	(	PUNCT
admet-387	326	16	1990	1990	NUM
admet-387	326	17	)	)	PUNCT
admet-387	326	18	303	303	NUM
admet-387	326	19	-	-	SYM
admet-387	326	20	312	312	NUM
admet-387	326	21	.	.	PUNCT
admet-387	327	1	[	[	X
admet-387	327	2	59	59	NUM
admet-387	327	3	]	]	PUNCT
admet-387	327	4	e.	e.	PROPN
admet-387	327	5	leal	leal	PROPN
admet-387	327	6	-	-	PUNCT
admet-387	327	7	pinto	pinto	NOUN
admet-387	327	8	,	,	PUNCT
admet-387	327	9	w.	w.	PROPN
admet-387	327	10	tao	tao	PROPN
admet-387	327	11	,	,	PUNCT
admet-387	327	12	j.	j.	PROPN
admet-387	327	13	rappaport	rappaport	PROPN
admet-387	327	14	,	,	PUNCT
admet-387	327	15	m.	m.	PROPN
admet-387	327	16	richardson	richardson	PROPN
admet-387	327	17	,	,	PUNCT
admet-387	327	18	b.a	b.a	PROPN
admet-387	327	19	.	.	PROPN
admet-387	327	20	knorr	knorr	PROPN
admet-387	327	21	,	,	PUNCT
admet-387	327	22	r.g	r.g	PROPN
admet-387	327	23	.	.	PROPN
admet-387	327	24	abramson	abramson	PROPN
admet-387	327	25	,	,	PUNCT
admet-387	327	26	the	the	DET
admet-387	327	27	journal	journal	NOUN
admet-387	327	28	of	of	ADP
admet-387	327	29	biological	biological	ADJ
admet-387	327	30	chemistry	chemistry	NOUN
admet-387	327	31	272	272	NUM
admet-387	327	32	(	(	PUNCT
admet-387	327	33	1997	1997	NUM
admet-387	327	34	)	)	PUNCT
admet-387	327	35	617	617	NUM
admet-387	327	36	-	-	SYM
admet-387	327	37	625	625	NUM
admet-387	327	38	.	.	PUNCT
admet-387	328	1	[	[	X
admet-387	328	2	60	60	NUM
admet-387	328	3	]	]	X
admet-387	328	4	n.	n.	NOUN
admet-387	328	5	anzai	anzai	PROPN
admet-387	328	6	,	,	PUNCT
admet-387	328	7	y.	y.	PROPN
admet-387	328	8	kanai	kanai	PROPN
admet-387	328	9	,	,	PUNCT
admet-387	328	10	h.	h.	PROPN
admet-387	328	11	endou	endou	NOUN
admet-387	328	12	,	,	PUNCT
admet-387	328	13	current	current	ADJ
admet-387	328	14	opinion	opinion	NOUN
admet-387	328	15	in	in	ADP
admet-387	328	16	rheumatology	rheumatology	NOUN
admet-387	328	17	19	19	NUM
admet-387	328	18	(	(	PUNCT
admet-387	328	19	2007	2007	NUM
admet-387	328	20	)	)	PUNCT
admet-387	328	21	151	151	NUM
admet-387	328	22	-	-	SYM
admet-387	328	23	157	157	NUM
admet-387	328	24	.	.	PUNCT
admet-387	329	1	[	[	X
admet-387	329	2	61	61	NUM
admet-387	329	3	]	]	X
admet-387	329	4	d.	d.	PROPN
admet-387	329	5	dinour	dinour	PROPN
admet-387	329	6	,	,	PUNCT
admet-387	329	7	n.k	n.k	PROPN
admet-387	329	8	.	.	NOUN
admet-387	329	9	gray	gray	PROPN
admet-387	329	10	,	,	PUNCT
admet-387	329	11	s.	s.	PROPN
admet-387	329	12	campbell	campbell	PROPN
admet-387	329	13	,	,	PUNCT
admet-387	329	14	x.	x.	PROPN
admet-387	329	15	shu	shu	PROPN
admet-387	329	16	,	,	PUNCT
admet-387	329	17	l.	l.	PROPN
admet-387	329	18	sawyer	sawyer	PROPN
admet-387	329	19	,	,	PUNCT
admet-387	329	20	w.	w.	PROPN
admet-387	329	21	richardson	richardson	PROPN
admet-387	329	22	,	,	PUNCT
admet-387	329	23	et	et	PROPN
admet-387	329	24	al	al	PROPN
admet-387	329	25	.	.	PROPN
admet-387	329	26	journal	journal	PROPN
admet-387	329	27	of	of	ADP
admet-387	329	28	the	the	DET
admet-387	329	29	american	american	ADJ
admet-387	329	30	society	society	NOUN
admet-387	329	31	of	of	ADP
admet-387	329	32	nephrology	nephrology	NOUN
admet-387	329	33	:	:	PUNCT
admet-387	329	34	jasn	jasn	NOUN
admet-387	329	35	21	21	NUM
admet-387	329	36	(	(	PUNCT
admet-387	329	37	2010	2010	NUM
admet-387	329	38	)	)	PUNCT
admet-387	329	39	64	64	NUM
admet-387	329	40	-	-	SYM
admet-387	329	41	72	72	NUM
admet-387	329	42	.	.	PUNCT
admet-387	330	1	[	[	X
admet-387	330	2	62	62	NUM
admet-387	330	3	]	]	PUNCT
admet-387	330	4	a.	a.	PROPN
admet-387	330	5	ochi	ochi	PROPN
admet-387	330	6	,	,	PUNCT
admet-387	330	7	t.	t.	PROPN
admet-387	330	8	takei	takei	PROPN
admet-387	330	9	,	,	PUNCT
admet-387	330	10	a.	a.	NOUN
admet-387	330	11	ichikawa	ichikawa	PROPN
admet-387	330	12	,	,	PUNCT
admet-387	330	13	c.	c.	PROPN
admet-387	330	14	kojima	kojima	PROPN
admet-387	330	15	,	,	PUNCT
admet-387	330	16	t.	t.	PROPN
admet-387	330	17	moriyama	moriyama	NOUN
admet-387	330	18	,	,	PUNCT
admet-387	330	19	m.	m.	NOUN
admet-387	330	20	itabashi	itabashi	PROPN
admet-387	330	21	,	,	PUNCT
admet-387	330	22	t.	t.	PROPN
admet-387	330	23	mochizuki	mochizuki	PROPN
admet-387	330	24	,	,	PUNCT
admet-387	330	25	a.	a.	PROPN
admet-387	330	26	taniguchi	taniguchi	PROPN
admet-387	330	27	,	,	PUNCT
admet-387	330	28	k.	k.	PROPN
admet-387	330	29	nitta	nitta	PROPN
admet-387	330	30	,	,	PUNCT
admet-387	330	31	clinical	clinical	ADJ
admet-387	330	32	and	and	CCONJ
admet-387	330	33	experimental	experimental	ADJ
admet-387	330	34	nephrology	nephrology	NOUN
admet-387	330	35	16	16	NUM
admet-387	330	36	(	(	PUNCT
admet-387	330	37	2012	2012	NUM
admet-387	330	38	)	)	PUNCT
admet-387	330	39	316	316	NUM
admet-387	330	40	-	-	SYM
admet-387	330	41	319	319	NUM
admet-387	330	42	.	.	PUNCT
admet-387	331	1	[	[	X
admet-387	331	2	63	63	NUM
admet-387	331	3	]	]	X
admet-387	331	4	y.	y.	PROPN
admet-387	331	5	takiue	takiue	PROPN
admet-387	331	6	,	,	PUNCT
admet-387	331	7	m.	m.	NOUN
admet-387	331	8	hosoyamada	hosoyamada	PROPN
admet-387	331	9	,	,	PUNCT
admet-387	331	10	m.	m.	NOUN
admet-387	331	11	kimura	kimura	PROPN
admet-387	331	12	,	,	PUNCT
admet-387	331	13	h.	h.	PROPN
admet-387	331	14	saito	saito	PROPN
admet-387	331	15	,	,	PUNCT
admet-387	331	16	nucleosides	nucleoside	NOUN
admet-387	331	17	,	,	PUNCT
admet-387	331	18	nucleotides	nucleotide	NOUN
admet-387	331	19	&	&	CCONJ
admet-387	331	20	nucleic	nucleic	ADJ
admet-387	331	21	acids	acid	NOUN
admet-387	331	22	30	30	NUM
admet-387	331	23	(	(	PUNCT
admet-387	331	24	2011	2011	NUM
admet-387	331	25	)	)	PUNCT
admet-387	331	26	113	113	NUM
admet-387	331	27	-	-	SYM
admet-387	331	28	119	119	NUM
admet-387	331	29	.	.	PUNCT
admet-387	332	1	[	[	X
admet-387	332	2	64	64	NUM
admet-387	332	3	]	]	SYM
admet-387	332	4	f.m	f.m	PROPN
admet-387	332	5	.	.	PROPN
admet-387	332	6	anton	anton	PROPN
admet-387	332	7	,	,	PUNCT
admet-387	332	8	j.	j.	PROPN
admet-387	332	9	garcia	garcia	PROPN
admet-387	332	10	puig	puig	PROPN
admet-387	332	11	,	,	PUNCT
admet-387	332	12	t.	t.	PROPN
admet-387	332	13	ramos	ramos	PROPN
admet-387	332	14	,	,	PUNCT
admet-387	332	15	p.	p.	PROPN
admet-387	332	16	gonzalez	gonzalez	PROPN
admet-387	332	17	,	,	PUNCT
admet-387	332	18	j.	j.	PROPN
admet-387	332	19	ordas	ordas	PROPN
admet-387	332	20	,	,	PUNCT
admet-387	332	21	metabolism	metabolism	NOUN
admet-387	332	22	:	:	PUNCT
admet-387	332	23	clinical	clinical	ADJ
admet-387	332	24	and	and	CCONJ
admet-387	332	25	experimental	experimental	ADJ
admet-387	332	26	35	35	NUM
admet-387	332	27	(	(	PUNCT
admet-387	332	28	1986	1986	NUM
admet-387	332	29	)	)	PUNCT
admet-387	332	30	343	343	NUM
admet-387	332	31	-	-	SYM
admet-387	332	32	348	348	NUM
admet-387	332	33	.	.	PUNCT
admet-387	333	1	[	[	X
admet-387	333	2	65	65	NUM
admet-387	333	3	]	]	X
admet-387	333	4	e.	e.	PROPN
admet-387	333	5	lioudaki	lioudaki	PROPN
admet-387	333	6	,	,	PUNCT
admet-387	333	7	e.s	e.s	PROPN
admet-387	333	8	.	.	PROPN
admet-387	333	9	ganotakis	ganotakis	PROPN
admet-387	333	10	,	,	PUNCT
admet-387	333	11	d.p	d.p	PROPN
admet-387	333	12	.	.	PROPN
admet-387	333	13	mikhailidis	mikhailidis	PROPN
admet-387	333	14	,	,	PUNCT
admet-387	333	15	d.r	d.r	PROPN
admet-387	333	16	.	.	PROPN
admet-387	333	17	nair	nair	PROPN
admet-387	333	18	,	,	PUNCT
admet-387	333	19	current	current	ADJ
admet-387	333	20	pharmaceutical	pharmaceutical	NOUN
admet-387	333	21	design	design	NOUN
admet-387	333	22	16	16	NUM
admet-387	333	23	(	(	PUNCT
admet-387	333	24	2010	2010	NUM
admet-387	333	25	)	)	PUNCT
admet-387	333	26	3815	3815	NUM
admet-387	333	27	-	-	SYM
admet-387	333	28	3822	3822	NUM
admet-387	333	29	.	.	PUNCT
admet-387	334	1	[	[	X
admet-387	334	2	66	66	NUM
admet-387	334	3	]	]	X
admet-387	334	4	c.g	c.g	PROPN
admet-387	334	5	.	.	PROPN
admet-387	334	6	wermuth	wermuth	PROPN
admet-387	334	7	,	,	PUNCT
admet-387	334	8	the	the	DET
admet-387	334	9	practice	practice	NOUN
admet-387	334	10	of	of	ADP
admet-387	334	11	medicinal	medicinal	ADJ
admet-387	334	12	chemistry	chemistry	NOUN
admet-387	334	13	,	,	PUNCT
admet-387	334	14	2nd	2nd	ADJ
admet-387	334	15	ed	ed	NOUN
admet-387	334	16	.	.	PROPN
admet-387	334	17	,	,	PUNCT
admet-387	334	18	academic	academic	ADJ
admet-387	334	19	,	,	PUNCT
admet-387	334	20	amsterdam	amsterdam	PROPN
admet-387	334	21	;	;	PUNCT
admet-387	334	22	london	london	PROPN
admet-387	334	23	,	,	PUNCT
admet-387	334	24	2003	2003	NUM
admet-387	334	25	.	.	PUNCT
admet-387	335	1	[	[	X
admet-387	335	2	67	67	NUM
admet-387	335	3	]	]	X
admet-387	335	4	i.	i.	PROPN
admet-387	335	5	walter	walter	PROPN
admet-387	335	6	-	-	PUNCT
admet-387	335	7	sack	sack	PROPN
admet-387	335	8	,	,	PUNCT
admet-387	335	9	j.x	j.x	PROPN
admet-387	335	10	.	.	PROPN
admet-387	335	11	de	de	PROPN
admet-387	335	12	vries	vries	PROPN
admet-387	335	13	,	,	PUNCT
admet-387	335	14	a.	a.	PROPN
admet-387	335	15	von	von	PROPN
admet-387	335	16	bubnoff	bubnoff	PROPN
admet-387	335	17	,	,	PUNCT
admet-387	335	18	v.	v.	ADP
admet-387	335	19	pfleilschifter	pfleilschifter	PROPN
admet-387	335	20	,	,	PUNCT
admet-387	335	21	r.	r.	PROPN
admet-387	335	22	raedsch	raedsch	PROPN
admet-387	335	23	,	,	PUNCT
admet-387	335	24	european	european	PROPN
admet-387	335	25	journal	journal	PROPN
admet-387	335	26	of	of	ADP
admet-387	335	27	medical	medical	ADJ
admet-387	335	28	research	research	NOUN
admet-387	335	29	1	1	NUM
admet-387	335	30	(	(	PUNCT
admet-387	335	31	1995	1995	NUM
admet-387	335	32	)	)	PUNCT
admet-387	335	33	16	16	NUM
admet-387	335	34	-	-	SYM
admet-387	335	35	20	20	NUM
admet-387	335	36	.	.	PUNCT
admet-387	336	1	[	[	X
admet-387	336	2	68	68	NUM
admet-387	336	3	]	]	X
admet-387	336	4	n.	n.	NOUN
admet-387	336	5	robbins	robbins	PROPN
admet-387	336	6	,	,	PUNCT
admet-387	336	7	s.e	s.e	PROPN
admet-387	336	8	.	.	PROPN
admet-387	336	9	koch	koch	PROPN
admet-387	336	10	,	,	PUNCT
admet-387	336	11	m.	m.	NOUN
admet-387	336	12	tranter	tranter	NOUN
admet-387	336	13	,	,	PUNCT
admet-387	336	14	j.	j.	PROPN
admet-387	336	15	rubinstein	rubinstein	PROPN
admet-387	336	16	,	,	PUNCT
admet-387	336	17	cardiovascular	cardiovascular	ADJ
admet-387	336	18	toxicology	toxicology	NOUN
admet-387	336	19	12	12	NUM
admet-387	336	20	(	(	PUNCT
admet-387	336	21	2012	2012	NUM
admet-387	336	22	)	)	PUNCT
admet-387	336	23	1	1	NUM
admet-387	336	24	-	-	SYM
admet-387	336	25	9	9	NUM
admet-387	336	26	.	.	PUNCT
admet-387	337	1	[	[	X
admet-387	337	2	69	69	NUM
admet-387	337	3	]	]	X
admet-387	337	4	p.k	p.k	PROPN
admet-387	337	5	.	.	PROPN
admet-387	337	6	tan	tan	PROPN
admet-387	337	7	,	,	PUNCT
admet-387	337	8	s.	s.	PROPN
admet-387	337	9	liu	liu	PROPN
admet-387	337	10	,	,	PUNCT
admet-387	337	11	e.	e.	PROPN
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admet-387	337	13	,	,	PUNCT
admet-387	337	14	j.n	j.n	PROPN
admet-387	337	15	.	.	PROPN
admet-387	337	16	miner	miner	NOUN
admet-387	337	17	,	,	PUNCT
admet-387	337	18	scientific	scientific	ADJ
admet-387	337	19	reports	report	NOUN
admet-387	337	20	7	7	NUM
admet-387	337	21	(	(	PUNCT
admet-387	337	22	2017	2017	NUM
admet-387	337	23	)	)	PUNCT
admet-387	337	24	665	665	NUM
admet-387	337	25	.	.	PUNCT
admet-387	338	1	admet	admet	PROPN
admet-387	338	2	&	&	CCONJ
admet-387	338	3	dmpk	dmpk	PROPN
admet-387	338	4	5(2	5(2	NUM
admet-387	338	5	)	)	PUNCT
admet-387	338	6	(	(	PUNCT
admet-387	338	7	2017	2017	NUM
admet-387	338	8	)	)	PUNCT
admet-387	338	9	59	59	NUM
admet-387	338	10	-	-	SYM
admet-387	338	11	74	74	NUM
admet-387	338	12	uric	uric	ADJ
admet-387	338	13	acid	acid	NOUN
admet-387	338	14	transporter	transporter	NOUN
admet-387	338	15	inhibitors	inhibitor	NOUN
admet-387	338	16	for	for	ADP
admet-387	338	17	gout	gout	NOUN
admet-387	338	18	doi	doi	NOUN
admet-387	338	19	:	:	PUNCT
admet-387	338	20	10.5599	10.5599	NUM
admet-387	338	21	/	/	SYM
admet-387	338	22	admet.5.1.387	admet.5.1.387	NOUN
admet-387	338	23	73	73	NUM
admet-387	339	1	[	[	X
admet-387	339	2	70	70	NUM
admet-387	339	3	]	]	X
admet-387	339	4	c.	c.	PROPN
admet-387	339	5	diaz	diaz	PROPN
admet-387	339	6	-	-	PUNCT
admet-387	339	7	torne	torne	ADJ
admet-387	339	8	,	,	PUNCT
admet-387	339	9	n.	n.	PROPN
admet-387	339	10	perez	perez	PROPN
admet-387	339	11	-	-	PUNCT
admet-387	339	12	herrero	herrero	PROPN
admet-387	339	13	,	,	PUNCT
admet-387	339	14	f.	f.	PROPN
admet-387	339	15	perez	perez	PROPN
admet-387	339	16	-	-	PUNCT
admet-387	339	17	ruiz	ruiz	NOUN
admet-387	339	18	,	,	PUNCT
admet-387	339	19	current	current	ADJ
admet-387	339	20	opinion	opinion	NOUN
admet-387	339	21	in	in	ADP
admet-387	339	22	rheumatology	rheumatology	NOUN
admet-387	339	23	27	27	NUM
admet-387	339	24	(	(	PUNCT
admet-387	339	25	2015	2015	NUM
admet-387	339	26	)	)	PUNCT
admet-387	339	27	164	164	NUM
admet-387	339	28	-	-	SYM
admet-387	339	29	169	169	NUM
admet-387	339	30	.	.	PUNCT
admet-387	340	1	[	[	X
admet-387	340	2	71	71	NUM
admet-387	340	3	]	]	PUNCT
admet-387	340	4	j.	j.	PROPN
admet-387	340	5	poiley	poiley	PROPN
admet-387	340	6	,	,	PUNCT
admet-387	340	7	a.s	a.s	PROPN
admet-387	340	8	.	.	PROPN
admet-387	340	9	steinberg	steinberg	PROPN
admet-387	340	10	,	,	PUNCT
admet-387	340	11	y.j	y.j	PROPN
admet-387	340	12	.	.	PUNCT
admet-387	340	13	choi	choi	PROPN
admet-387	340	14	,	,	PUNCT
admet-387	340	15	c.s	c.s	PROPN
admet-387	340	16	.	.	PROPN
admet-387	340	17	davis	davis	PROPN
admet-387	340	18	,	,	PUNCT
admet-387	340	19	r.l	r.l	PROPN
admet-387	340	20	.	.	PROPN
admet-387	340	21	martin	martin	PROPN
admet-387	340	22	,	,	PUNCT
admet-387	340	23	c.a	c.a	PROPN
admet-387	340	24	.	.	PROPN
admet-387	340	25	mcwherter	mcwherter	PROPN
admet-387	340	26	,	,	PUNCT
admet-387	340	27	p.f	p.f	PROPN
admet-387	340	28	.	.	PROPN
admet-387	340	29	boudes	boude	NOUN
admet-387	340	30	,	,	PUNCT
admet-387	340	31	i.	i.	PROPN
admet-387	340	32	arhalofenate	arhalofenate	PROPN
admet-387	340	33	flare	flare	PROPN
admet-387	340	34	study	study	NOUN
admet-387	340	35	,	,	PUNCT
admet-387	340	36	arthritis	arthritis	PROPN
admet-387	340	37	&	&	CCONJ
admet-387	340	38	rheumatology	rheumatology	PROPN
admet-387	340	39	68	68	NUM
admet-387	340	40	(	(	PUNCT
admet-387	340	41	2016	2016	NUM
admet-387	340	42	)	)	PUNCT
admet-387	340	43	2027	2027	NUM
admet-387	340	44	-	-	SYM
admet-387	340	45	2034	2034	NUM
admet-387	340	46	.	.	PUNCT
admet-387	341	1	©	©	PROPN
admet-387	341	2	2017	2017	NUM
admet-387	341	3	by	by	ADP
admet-387	341	4	the	the	DET
admet-387	341	5	authors	author	NOUN
admet-387	341	6	;	;	PUNCT
admet-387	341	7	licensee	licensee	PROPN
admet-387	341	8	iapc	iapc	PROPN
admet-387	341	9	,	,	PUNCT
admet-387	341	10	zagreb	zagreb	PROPN
admet-387	341	11	,	,	PUNCT
admet-387	341	12	croatia	croatia	PROPN
admet-387	341	13	.	.	PUNCT
admet-387	342	1	this	this	DET
admet-387	342	2	article	article	NOUN
admet-387	342	3	is	be	AUX
admet-387	342	4	an	an	DET
admet-387	342	5	open	open	ADJ
admet-387	342	6	-	-	PUNCT
admet-387	342	7	access	access	NOUN
admet-387	342	8	article	article	NOUN
admet-387	342	9	distributed	distribute	VERB
admet-387	342	10	under	under	ADP
admet-387	342	11	the	the	DET
admet-387	342	12	terms	term	NOUN
admet-387	342	13	and	and	CCONJ
admet-387	342	14	conditions	condition	NOUN
admet-387	342	15	of	of	ADP
admet-387	342	16	the	the	DET
admet-387	342	17	creative	creative	ADJ
admet-387	342	18	commons	common	NOUN
admet-387	342	19	attribution	attribution	NOUN
admet-387	342	20	license	license	NOUN
admet-387	342	21	(	(	PUNCT
admet-387	342	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-387	342	23	)	)	PUNCT
admet-387	342	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-387	342	25	tan	tan	PROPN
admet-387	342	26	and	and	CCONJ
admet-387	342	27	miner	miner	PROPN
admet-387	342	28	admet	admet	PROPN
admet-387	342	29	&	&	CCONJ
admet-387	342	30	dmpk	dmpk	PROPN
admet-387	342	31	5(2	5(2	NUM
admet-387	342	32	)	)	PUNCT
admet-387	342	33	(	(	PUNCT
admet-387	342	34	2017	2017	NUM
admet-387	342	35	)	)	PUNCT
admet-387	342	36	59	59	NUM
admet-387	342	37	-	-	SYM
admet-387	342	38	74	74	NUM
admet-387	342	39	74	74	NUM
admet-387	342	40	supplementary	supplementary	ADJ
admet-387	342	41	figure	figure	NOUN
admet-387	342	42	figure	figure	NOUN
admet-387	342	43	sp1	sp1	NOUN
admet-387	342	44	.	.	PUNCT
admet-387	343	1	photomicrograph	photomicrograph	NOUN
admet-387	343	2	under	under	ADP
admet-387	343	3	polarized	polarize	VERB
admet-387	343	4	light	light	NOUN
admet-387	343	5	of	of	ADP
admet-387	343	6	negatively	negatively	ADV
admet-387	343	7	birefringent	birefringent	VERB
admet-387	343	8	monosodium	monosodium	NOUN
admet-387	343	9	uric	uric	ADJ
admet-387	343	10	acid	acid	NOUN
admet-387	343	11	crystals	crystal	NOUN
admet-387	343	12	,	,	PUNCT
admet-387	343	13	the	the	DET
admet-387	343	14	underlying	underlying	ADJ
admet-387	343	15	cause	cause	NOUN
admet-387	343	16	of	of	ADP
admet-387	343	17	gouty	gouty	ADJ
admet-387	343	18	inflammation	inflammation	NOUN